NIH_SPENDING_CATS: Bioengineering;Clinical Research;Disability Research;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: CHICAGO

ORG_NAME: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB

ORG_STATE: IL

PHR: PROJECT NARRATIVE Falls are the second leading cause of unintentional death worldwide and lower limb prosthesis users constitute an exceptionally high-risk group. Currently, there are a lack of clinically accessible tools that can robustly predict fall risk across a representative sample of lower limb prosthesis users. Gait analysis performed with markerless motion capture has the potential to identify causal, modifiable, biomechanical risk factor for falls and could produce a cost-effective and easy-to-use fall risk screening framework.

PI_NAMEs: COTTON, RONALD JAMES (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Amputation;Amputees;analysis pipeline;Ankle;Biological Markers;biomechanical test;Biomechanics;Cessation of life;Classification;Clinic;Clinical;Clinical assessments;clinical encounter;clinically actionable;Collection;Communities;comorbidity;Consensus;cost effective;Data;Development;Eligibility Determination;Equilibrium;Etiology;Fall prevention;fall risk;falls;Frequencies;Future;Gait;gait examination;Goals;Heterogeneity;high risk;high risk population;Hip region structure;Home;improved;inclusion criteria;Individual;Injury;innovation;insight;Intervention;kinematics;Lateral;Limb Prosthesis;Lower Extremity;Measurable;Measurement;Measures;Methods;Microprocessor;Modeling;Monitor;Morbidity - disease rate;mortality;Motion;Odds Ratio;older adult;open source;Outcome;Participant;Performance;performance based measurement;Population;Population Heterogeneity;Populations at Risk;predictive modeling;predictive test;predictive tools;Prevention Research;preventive intervention;programs;prospective;Prosthesis;prosthesis wearer;Randomized, Controlled Trials;Recording of previous events;Rehabilitation therapy;Reporting;research study;Risk;Risk Factors;Risk Marker;Sampling;screening;Screening procedure;sensor;Specificity;statistics;Step Tests;stroke survivor;Subgroup;Surveys;System;Taxonomy;Techniques;Testing;Time;Toes;tool;Visit;Walking;wearable sensor technology;Width;Work

PROJECT_TITLE: Predictive Gait-Based Biomarkers for Fall Risk in Lower-Limb Prosthesis Users

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Wound Healing and Care

ORG_CITY: INDIANAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SURGERY

ORG_FIPS: US

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The mechanism of sensory innervation-induced regulation of limbal stem cells (LSCs) during corneal epithelial renewal, required for corneal maintenance and wound healing and ultimately critical for vision, is unknown. Based on preliminary findings, we hypothesize that Schwann cells (SCs) residing in the corneal limbus alongside LSCs are critical in mediating the innervation-dependent activity of LSCs. Therefore, we propose mechanistically defining the paracrine interactions between SCs and LSCs that regulate LSC activity, which, in turn, will enable development of novel topical therapeutics to treat NK in human patients.

PI_NAMEs: BORSCHEL, GREGORY HOWARD (contact);FEINBERG, KONSTANTIN

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Ablation;Affect;afferent nerve;American;Animal Model;Axon;Blindness;blink reflexes;Body part;candidate identification;Cell Communication;Cell Maintenance;Cell Survival;Cells;Chronic;cleft lip and palate;Clinical;clinical practice;clinical translation;Compensation;Cornea;corneal epithelial wound healing;corneal epithelium;Corneal Injury;corneal surgery;Corneal Ulcer;Denervation;Deterioration;Development;Epithelial Cells;Epithelium;experimental study;Face;Failure;FDA approved;Free Nerve Ending;Future;gain of function;Gatekeeping;Genetic;healing;Health;Human;Impairment;improved;improved outcome;In Vitro;in vivo;Incidence;Infection;Injury;innovation;insight;Institution;Investigation;Keratopathy;Knowledge;Legal patent;Libraries;limbal;Limbus Corneae;loss of function;Maintenance;Mediating;migration;Modeling;Molecular;Mus;Nerve;Nerve Growth Factors;nerve supply;Nerve Transfer;Neurons;novel;novel therapeutics;ocular surface;operation;Operative Surgical Procedures;paracrine;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Population;Presynaptic Terminals;Procedures;Protein Secretion;Recombinants;Recovery;Regulation;reinnervation;release factor;Reporting;Research Proposals;Rodent;Role;Running;Schwann Cells;Sensory;sensory mechanism;single-cell RNA sequencing;stem cell biology;stem cell niche;stem cell proliferation;stem cells;Therapeutic;Tissues;Topical application;Trauma;tumor;Uncertainty;Vision;wound healing

PROJECT_TITLE: Mechanisms Governing Nerve-Mediated Control of Corneal Wound Healing: New Hope for Patients with Neurotrophic Keratopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative  Triple-negative breast cancer is highly aggressive and uniformly lethal in the metastatic setting, highlighting the need for improved immunological control strategies for this disease. This project seeks to evaluate how the intracellular domain of the immune checkpoint receptor VISTA functions in triple-negative breast cancer. This should lead to the development of novel immunotherapeutic strategies to target VISTA for breast cancer and possibly other malignancies.

PI_NAMEs: GRUBER, JOSHUA JAMES (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Adaptor Signaling Protein;Address;Binding;Binding Proteins;Biochemical;Biological;Biological Models;Blocking Antibodies;Breast Cancer Model;Cell Line;Cell membrane;Cell Surface Receptors;cell type;Cells;checkpoint receptors;Clathrin;Clathrin Adaptors;clinical development;Clinical Research;Clinical Trials;Complex;Cytoplasm;Data;Defect;Development;Disease;Drug Targeting;Endocytosis;Engineering;Epidermal Growth Factor Receptor;experimental study;extracellular;Extracellular Domain;first-in-human;Future;Genetic Engineering;Growth;Human;human model;Immune;immune activation;immune checkpoint;immune modulating agents;Immunocompetent;Immunoglobulin Domain;Immunologic Receptors;Immunologics;immunosuppressed;Immunosuppression;Immunotherapeutic agent;Impairment;improved;improved outcome;indexing;individualized medicine;interest;Laboratories;Malignant Breast Neoplasm;Malignant Neoplasms;Membrane;method development;Molecular;mouse model;mutant;Mutation;Myeloid Cells;neoplastic cell;novel;Outcome;overexpression;Pathway interactions;Patients;Phase I Clinical Trials;Physiology;preclinical study;prevent;programmed cell death ligand 1;programs;Property;protein purification;PTB Domain;receptor;Receptor Activation;receptor function;Recombinant Proteins;recruit;Regimen;Repression;Role;Safety;Signal Transduction;Suppressor-Effector T-Lymphocytes;T-Cell Activation;targeted treatment;Testing;Therapeutic;TLR4 gene;trafficking;translation to humans;treatment response;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Work

PROJECT_TITLE: Molecular mechanisms and therapeutic principles of VISTA+ triple-negative breast cancers

STUDY_SECTION: TIO

STUDY_SECTION_NAME: Translational Immuno-oncology Study Section[TIO]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The establishment of germline sexual identity is critical for the development of germline stem cells and formation of sperm and eggs necessary for reproduction. This proposal addresses fundamental mechanisms that determine germline sexual identity.

PI_NAMEs: VAN DOREN, MARK B (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Address;Animals;Biotinylation;Caenorhabditis elegans;Cell Physiology;Constitution;Cues;Cytoplasm;Cytoplasmic Granules;Data;Development;Drosophila genus;egg;Female;fly;Gametogenesis;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genomics;Germ;Germ Cells;Germ Lines;germline stem cells;gonad development;Gonadal structure;Human;male;Mass Spectrum Analysis;Membrane;Messenger RNA;Modeling;Molecular Mechanisms of Action;Mus;neuronal cell body;novel;Organelles;Pathway interactions;Post-Transcriptional Regulation;posttranscriptional;preservation;Process;programs;Protein Family;Proteins;Regulation;Repression;Reproduction;RNA;RNA-Binding Proteins;sex;Sex Chromosomes;sex determination;sexual identity;Signal Transduction;Somatic Cell;Specific qualifier value;sperm cell;Spermatocytes;Structure;Structure of primordial sex cell;Tertiary Protein Structure;Testing;Time;Trans-Activators;Transcript;Work

PROJECT_TITLE: Investigating Germline Sex Determination

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Native Hawaiian individuals represent one of the most underserved and understudied populations in medical research despite being one of the fastest growing populations in the US and facing alarming long-standing health disparities, many of which are metabolic in nature. In this study, we will generate large-scale metabolomic data in this population and Japanese Americans, who have complementary risk profiles compared to Native Hawaiians, to investigate genetic factors contributing to metabolic profiles in these populations and metabolic factors that contribute to the health and health disparities of these populations. This investigation will greatly bolster epidemiologic research in these understudied populations, and findings are expected to have important implications for mitigating health disparities.

PI_NAMEs: DARST, BURCU FRANCES (contact)

PROGRAM_OFFICER_NAME: YAN, YE

PROJECT_TERMS: Accounting;Address;American;Asian Americans;Asian ancestry;Asian population;Biological Markers;Blood specimen;Body mass index;Cardiometabolic Disease;cardiometabolism;cardiovascular disorder risk;Cholesterol;cohort;Data;Dedications;diabetes risk;dietary;Disease;disease disparity;disorder risk;Disparity;disparity reduction;East Asian;Environmental Risk Factor;Epidemiology;epidemiology study;Etiology;European;European ancestry;Face;follow-up;Genetic;genetic architecture;Genome;genome wide association study;genomic locus;Genomics;Gout;Hawaiian population;Health;health disparity;health disparity populations;health equity promotion;Healthcare;Heart failure;high body mass index;high risk;Hypertension;improved;Individual;Inflammation;innovation;insight;Insulin Resistance;Investigation;Japanese;Japanese American;Japanese Population;Knowledge;Life Style;Link;Mediating;Medical Research;Metabolic;metabolic profile;metabolome;metabolomics;multi-ethnic;Native Hawaiian;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Pacific Islander;Participant;Play;Polynesian;Population;population health;Prevention;Prevention strategy;Reduce health disparities;Research;Research Priority;Resources;Risk;Risk Factors;risk prediction;Role;Sampling;Smoking Status;socioeconomics;statistics;stroke risk;subcutaneous;Technology;Therapeutic;trait;treatment strategy;United States National Institutes of Health;Variant;Visceral fat

PROJECT_TITLE: Leveraging metabolomics to identify factors contributing to health disparities in Native Hawaiian individuals

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE Impaired mitochondrial biology in brain and immune cells is an emerging candidate mechanism for Alzheimer’s disease (AD) pathogenesis, but rigorously testing this hypothesis requires scalable approaches to profile mitochondrial phenotypes will cell-type specific resolution. In this proposal, we develop for public use and deploy a novel mitochondrial phenotyping approach – mitotyping – in brain cortical cells (ROSMAP cohort, n=381) and in circulating immune cells (RANN/CR cohort, n=175), and link the resulting cell type-specific mitotype alterations to age, cognitive reserve, and AD pathology among women and men. Mechanistically, we also deepen our understanding of mitotypes by complementing these studies with in vitro experiments that establish how primary energetic mitochondrial perturbations dynamically alter other domains of mitochondrial biology within single cells, between cells, and among immune cells of patients with rare mitochondrial DNA defects, thereby providing a novel approach, framework, and foundation to explore the role of mitochondrial alterations in human health and disease.

PI_NAMEs: PICARD, MARTIN  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Address;Adult;Age;age related;age related changes;Age-associated memory impairment;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Autopsy;Bioenergetics;Biological;Biology;Blood;Body System;Brain;brain abnormalities;brain cell;brain health;Calibration;Cell Communication;cell cortex;Cell Nucleus;cell type;Cells;Coculture Techniques;Cognitive;cognitive reserve;cohort;Communication;Communities;contagion;Data;data harmonization;Data Set;Defect;Dementia;Disease;ethnic diversity;Ethnic Origin;Exhibits;experimental study;Fibroblasts;Foundations;Gene Expression Regulation;Genes;Genetic;Genotype-Tissue Expression Project;Genus Hippocampus;Goals;Grain;hallmarks of aging;Health;Human;Immune;Immune system;Immunologist;immunoregulation;Impaired cognition;Impairment;in silico;In Vitro;in vivo;Individual;interest;life span;Link;Lymphocyte;Lymphoid;Maps;Measures;men;Metabolic;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial metabolism;Molecular;Molecular Profiling;monocyte;Mus;Myelogenous;Nerve Degeneration;neural;Neuroglia;neuroimmunology;Neuroimmunomodulation;Neurons;next generation;Normal Cell;novel;novel strategies;older adult;Organ;Organelles;Oxidative Phosphorylation;Oxidative Phosphorylation Deficiency;Pathogenesis;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Persons;pharmacologic;Phenotype;Play;Population;Prefrontal Cortex;Process;Proteomics;Research;Research Personnel;Resolution;Role;Scientist;sex;Shapes;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Specificity;System;Testing;Time;Tissues;tool;transcriptome sequencing;transcriptomics;Woman;Work

PROJECT_TITLE: Mapping Mitochondrial Diversity in the Aging Brain and Immune System

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Sleep Research;Telehealth

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: Project Narrative. Shift workers, including frontline healthcare workers, bear a disproportionately heavy burden of obesity and cardiometabolic diseases due to late night and erratic eating patterns, logistical challenges associated with receiving care, and near-universal exclusion from relevant clinical trials. Time-restricted eating is a simple lifestyle intervention that structures eating patterns and can lead to weight loss and cardiometabolic improvements independent of diet quality. We propose an innovative randomized control trial that utilizes remote monitoring and guidance, wearable medical devices, and a smartphone app to deliver and promote a TRE intervention to healthcare night-shift workers to promote weight loss, improve cardiometabolic health, and sustain behavior change in this vulnerable yet extremely vital part of our community.

PI_NAMEs: MANOOGIAN, EMILY NICOLE CORBETT (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Acceleration;Acute Respiratory Distress Syndrome;Address;Adherence;Adopted;Adult;adult obesity;Adverse effects;Affect;Animal Model;Area Under Curve;arm;Attention;barrier to care;behavior change;Behavior Therapy;Behavioral;Biological;Biological Markers;Biological Rhythm;Blood Glucose;Blood Pressure;Blood specimen;Body Weight;Body Weight decreased;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Caring;Cellular Phone;Cessation of life;Chronic Disease;Circadian Rhythms;Clinical;Clinical Research;Clinical Trials;clinically relevant;Communities;Consultations;Consumption;Continuous Glucose Monitor;COVID-19 pandemic;Cues;Diet;Diet and Nutrition;Dietary intake;Dietary Intervention;digital platform;digital technology;Discipline of Nursing;Disease Progression;disorder risk;Dual-Energy X-Ray Absorptiometry;E-learning;Eating;Educational Materials;effective intervention;efficacy evaluation;Exclusion;Exposure to;Fasting;fasting glucose;Fatty acid glycerol esters;fire fighter;follow up assessment;follow-up;Food;food consumption;Foundations;Glucose;Glycosylated hemoglobin A;Health;health disparity;Health Personnel;Health Status;Healthcare;healthy weight;high risk;Hour;Human;improved;Incidence;Inflammatory;innovation;interstitial;Intervention;Knowledge;LDL Cholesterol Lipoproteins;lifestyle intervention;Light;Measurement;Medical;Medical Device;Mediterranean Diet;men;Metabolic;Metabolic hormone;Metabolic syndrome;Methods;Minority;mobile computing;Monitor;Nature;Neurosecretory Systems;Non-Insulin-Dependent Diabetes Mellitus;Nurses;nutrition;Obesity;obesity management;obesity risk;Occupations;Organ;Outcome;Overweight;Participant;Patient Education;Patients;Pattern;Performance at work;Periodicals;Persons;pharmacologic;Population;pragmatic intervention;pre-clinical;Predisposition;Prevalence;prevent;primary outcome;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;real world application;Recommendation;recruit;Regulation;remote monitoring;Research;Research Design;Risk;Risk Factors;Risk Reduction;Rodent Model;Schedule;sensor;severe COVID-19;Severity of illness;SF-36;shift work;Sleep;sleep behavior;sleep pattern;Sleep Wake Cycle;smartphone application;sound;standard of care;Structure;sugar;Surveys;Technology;Telemedicine;Testing;Time-restricted feeding;tool;Treatment Failure;virtual;Visit;Vulnerable Populations;wearable device;wearable sensor technology;Weight Gain;wireless fidelity;Woman;Work

PROJECT_TITLE: Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: Boulder

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because elucidating novel mechanisms that underlie inflammation-induced sleep alterations is expected to improve the treatment of patients with sleep-related disturbances that increase inflammation, as well as individuals with diseases associated with elevated inflammation. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to developing fundamental knowledge that will serve to reduce the burdens of disorders and diseases that are associated with limited functionality and poor quality of life.

PI_NAMEs: ROWE, RACHEL KATHLEEN (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Anti-Inflammatory Agents;Astrocytes;astrogliosis;Biological;Brain;Cells;Central Nervous System;Chronic;comparison control;cytokine;Cytokine Signaling;Data;Disease;disorder risk;Estrous Cycle;experimental study;Feedback;Female;functional outcomes;glial activation;Health;Immune;Immune response;improved;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Interleukin-1;Interleukin-6;Intervention;Intraperitoneal Injections;Knock-out;Knockout Mice;Knowledge;Laboratories;Link;Lipopolysaccharides;Mediating;Microglia;Mission;Molecular;Morphology;mRNA Expression;Mus;Nerve Degeneration;Neuroglia;neuroinflammation;Neurons;non rapid eye movement;novel;Pathologic;Patients;Population;Public Health;Quality of life;receptor;Regulation;Research;response;RNA;Role;sex;sex cycle;Signal Transduction;single-cell RNA sequencing;Sleep;Sleep Deprivation;Sleep disturbances;sleep regulation;Technology;Testing;Time;TNF gene;transcriptome;United States National Institutes of Health;Work

PROJECT_TITLE: The mechanistic role of microglia and IL10 in the regulation of pathological sleep disturbances

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE The proposed research is relevant to public health because it focuses on developing a new human-cell based model system to recapitulate the functional and dysfunctional connectivity of the human brain with unprecedented fidelity. Thus, the proposed research is relevant to the part of the NIHM’s mission that pertains to treating neuropsychiatric disorders that often involve alterations in neural connectivity.

PI_NAMEs: QUADRATO, GIORGIA  (contact)

PROGRAM_OFFICER_NAME: KIM, DOUGLAS SUN-IL

PROJECT_TERMS: Address;Affect;Anatomy;autism spectrum disorder;Automobile Driving;Axon;axon growth;Biocompatible Materials;Biological Models;Bipolar Disorder;Brain;Brain Diseases;Brain imaging;Brain region;candidate identification;Cell Maturation;Cell Proliferation;Cells;Central Nervous System;cognitive capacity;Communities;Complex;crosslink;Data Set;Development;Device Designs;Devices;Discipline;Disease;Drug Screening;Emerging Technologies;Engineering;experimental study;Fostering;Frustration;Functional disorder;Future;Goals;Human;human pluripotent stem cell;Hydrogels;imaging approach;Immobilization;improved;in vivo;interest;Knowledge;Ligands;Maps;Mental disorders;Methods;Microfluidic Microchips;migration;Mission;Modeling;Molecular;molecular dynamics;multimodality;Mutation;Necrosis;Nervous System Disorder;neural;Neurites;neuronal patterning;Neurons;neuropsychiatric disorder;optic nerve disorder;optogenetics;Organoids;Oxygen;Pacemakers;particle;Pathology;Patients;Pattern;Phenotype;Photic Stimulation;Physiological;Pluripotent Stem Cells;Public Health;Reproducibility;Research;Research Personnel;Resolution;Resources;Retina;Retinal Diseases;scaffold;Schizophrenia;Scientist;Sensory;Structure;Synapses;synthetic biology;System;Technology;Testing;Thalamic structure;Tissue Engineering;transcriptome;Visual System

PROJECT_TITLE: A multi-organoid-on-a-chip platform for interrogating human brain (dys)connectivity

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Autism spectrum disorder (ASD), characterized by widespread impairments in physiological function that result in social deficits, has a prevalence rate of approximately 1 in 36 individuals. The current state of treatment uses non-targeted therapies that are often ineffective in a large percentage of patients and have a host of side effects. The objective of this proposal is to rigorously and mechanistically explore how robust enhancement of serotonin signaling via a short-term 2-dose MDMA intervention leads to long-lasting adaptations in a corticostriatal circuit and results in a sustained reversal of social deficits present in a genetic mouse model.

PI_NAMEs: WALSH, JESSICA JILLIAN (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Acute;Air Conditioning;Anxiety;autism spectrum disorder;Cells;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Clinical;Corpus striatum structure;Data;designer receptors exclusively activated by designer drugs;Development;Disease;Dose;ecstasy;effective therapy;Electrophysiology (science);Elements;Etiology;experience;Fiber;Functional disorder;Genes;Genetic;Goals;Heterozygote;Human;Impairment;improved;in vivo;Individual;individuals with autism spectrum disorder;Intervention;Kinetics;Maintenance;Medial;Mediator;Mental Depression;Mental disorders;model of autism spectrum disorder;Molecular;mouse model;Mus;Mutate;Nature;neural;neuroadaptation;Neurodevelopmental Disorder;neuromechanism;Neurons;neuropsychiatric disorder;novel;novel strategies;Nucleus Accumbens;optogenetics;Patients;Personal Satisfaction;Photometry;Physiological;Physiology;Play;Population;pre-clinical;Prefrontal Cortex;Prevalence;receptor;Regimen;Reproduction;Role;Schizophrenia;Selective Serotonin Reuptake Inhibitor;Serotonergic System;Serotonin;side effect;Signal Transduction;social;Social Behavior;social deficits;Speed;SWI/SNF Family Complex;System;targeted treatment;Therapeutic;Therapeutic Effect;therapeutic target;transcription factor;Work

PROJECT_TITLE: Neural mechanisms underlying sustained enhancement of sociability

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-Y (02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE SMARTLife Utah will provide critical data regarding the impact of pragmatic and scalable multilevel implementation strategies at both the clinic and patient level that are designed to increase the reach of existing digital evidence-based interventions for obesity among racial/ethnic minority, low socioeconomic status, and rural populations in low resource healthcare settings; and advance the field of dissemination and implementation science by testing key constructs hypothesized to influence implementation and effectiveness outcomes.

PI_NAMEs: DEL FIOL, GUILHERME ;SCHLECHTER, CHELSEY  (contact);WETTER, DAVID W

PROGRAM_OFFICER_NAME: AGURS-COLLINS, TANYA

PROJECT_TERMS: Academy;access disparities;Address;Adherence;Adult;Area;Body mass index;Body Weight;Body Weight decreased;Callback;cancer risk;Clinic;Clinic Visits;Clinical;Communities;Consensus;contextual factors;Data;design;Diet;digital;dissemination science;Effectiveness;effectiveness outcome;effectiveness/implementation design;Electronics;Enrollment;ethnic minority;Ethnic Population;Evidence based intervention;frontier;Funding;health care settings;health information technology;Health Resources;Hybrids;implementation outcomes;implementation science;implementation strategy;improved;Individual;Inequity;Insurance Coverage;intervention delivery;Latino;low socioeconomic status;Malignant Neoplasms;marginalization;marginalized population;Medicine;men;Minority Groups;Modality;Motivation;Neighborhood Health Center;obese patients;Obesity;obesity treatment;Outcome;patient navigation;patient navigator;patient oriented;patient population;Patients;Persons;Phase;Physical activity;physical inactivity;Play;point of care;Population;Poverty;Primary Care;primary care clinic;primary care provider;primary outcome;Problem Solving;programs;racial minority;Randomized;Recommendation;Research;response;Role;Rural;Rural Population;safety net;scale up;Sequential Multiple Assignment Randomized Trial;Support System;System;Technology;telehealth;Telephone;Testing;Text Messaging;Time;Transportation;trial design;Unhealthy Diet;Uninsured;United States Preventative Services Task Force;uptake;Use Effectiveness;Utah;web site;Weight;Woman

PROJECT_TITLE: Partnerships  to  Reduce  Obesity in  Community  Health  Center  Patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-9 (J2)]


NIH_SPENDING_CATS: Asthma;Clinical Research;Immunization;Infectious Diseases;Lung;Pediatric;Prevention;Vaccine Related

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project narrative Despite multilevel evidence that an infant who experiences a respiratory syncytial virus (RSV) infection during the first 12 months of life will have a higher chance of developing asthma later in life, the susceptibility window during infancy remains undefined and an age-dependent causal relationship remains unproven. The overarching goals of this study are to determine if RSV causes asthma, to identify the age range during which RSV infection is most likely to cause asthma, and to determine to what extent RSV prevention products, maternal vaccines and/or RSV monoclonal antibodies, decrease the risk for asthma. If RSV causes asthma and the effect is age-dependent, RSV prevention or delay could have short- and long-term benefits by reducing the burden of the two most common respiratory conditions that result in significant morbidity and mortality in infancy and childhood.

PI_NAMEs: HARTERT, TINA V;WU, PINGSHENG  (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: 18 year old;5 year old;Acute;Address;Adherence;Age;Age Months;age related;Asthma;asthma exacerbation;asthma prevention;Child;Childhood;Childhood Asthma;Circulation;Costs and Benefits;COVID-19 pandemic;Data;Date of birth;Department of Defense;design;Development;early childhood;Effectiveness;Emergency department visit;Enrollment;Etiology;expectation;experience;Genetic;Goals;Health;Health system;Healthcare Systems;Heredity;Hospitalization;Human;Individual;infancy;Infant;infant infection;Infection;infection risk;innovation;Interruption;Life;Link;low and middle-income countries;Lower Respiratory Tract Infection;Medicaid;Medical;Military Personnel;Monoclonal Antibodies;Morbidity - disease rate;mortality;Natural experiment;novel;Observational Study;Outcome;Outcome Study;pandemic disease;Pattern;Policies;policy recommendation;Population;Predisposition;Prevalence;prevent;Prevention;Prevention strategy;Primary Prevention;programs;Prospective Studies;Public Health;Recommendation;Recurrence;respiratory;Respiratory Disease;respiratory morbidity;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Syncytial Virus Vaccines;Retrospective Studies;Risk;Risk Factors;Seasons;Statistical Methods;study population;Tennessee;Testing;Time;Time Series Analysis;uptake;vaccine acceptance;vaccine-induced antibodies;Vaccines;Wheezing

PROJECT_TITLE: Establishing critical time windows of infant RSV infection in the causal relationship of RSV and childhood asthma

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Genetic Testing;Genetics;Health Services;Human Genome;Pediatric;Prevention

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE Genomic sequencing at birth has great potential to improve health not only by identifying infants with undiagnosed genetic conditions, but also by providing information that allows families to prevent disease altogether and to make better medical care decisions. In order for newborn genomic screening to achieve its potential, medical and public health systems will need to adapt existing newborn screening programs, families and clinicians will need to adapt to information and manage findings over long periods of time, and labs will need to reexamine genetic information to ensure findings are up-to-date with new knowledge. This study provides critically-needed evidence that will inform how newborn genetic screening programs should be developed and sustained to provide lifelong benefits.

PI_NAMEs: CHRISTENSEN, KURT DEREK (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Acceleration;Achievement;Address;Age;aged;Area;Behavioral;behavioral outcome;Birth;Caring;Cessation of life;Child;Child Care;Classification;Clinical;Clinical Trials;cohort;Complement;Consent;cost;cost comparison;cost effective;cost effectiveness;Data;design;Diagnosis;Diagnostic;Disease;DNA Resequencing;Drug Interactions;drug metabolism;Early Intervention;Ensure;Equilibrium;Family;Family Planning;Follow-Up Studies;Future;Genes;Genetic Diseases;genetic information;Genetic Predisposition to Disease;Genetic Screening;genetic testing;Genome;genomic profiles;genomic profiling;Genomics;Goals;Health;Health Personnel;health related quality of life;Health system;high risk;improved;Individual;Infant;Infant Care;Infant Mortality;informant;Infrastructure;Inherited;insight;Interview;Knowledge;Laboratories;Life Style;Longterm Follow-up;mathematical model;Medical;Modeling;models and simulation;Molecular;Molecular Abnormality;Morbidity - disease rate;Mutation;Neonatal Screening;Newborn Infant;Outcome;Parent-Child Relations;Parents;Participant;Patients;Pharmaceutical Preparations;Policy Maker;Population;population based;prevent;Process;programs;Protocols documentation;psychosocial;psychosocial outcome;Public Health;Randomized;Recommendation;Reporting;reproductive;Research;Resources;Risk;Safety;satisfaction;screening;Screening procedure;screening program;Sensitivity and Specificity;service intervention;Societies;Surveys;System;Time;time interval;tool;treatment as usual;Uncertainty;Variant

PROJECT_TITLE: Long-term Impact and Value of Infant Genomic Sequencing (LIVING)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW ORLEANS

ORG_DEPT: NEUROSURGERY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Vascular dementia (VaD) is the second leading cause of dementia behind Alzheimer’s disease (AD) but its pathogenesis is still only poorly understood. Building on the importance of pericytes (PC) in maintaining the blood-brain barrier (BBB) and previous studies showing that the extracellular matrix (ECM) protein perlecan inhibits pericyte functions, we recently found that aging, hypoxia and endothelial nitric oxide synthetase deficiency in mice trigger increased expression of perlecan, and diminished perlecan proteolysis into bioactive fragments in the vascular basement membrane, and that this correlates with reduced pericyte coverage and disrupted BBB integrity. In this proposal we aim to gain a deeper understanding of how perlecan regulates PC function, and then test the concept that manipulation of perlecan’s influence could be therapeutically beneficial in multiple models of VaD by enhancing PC coverage of cerebral blood vessels, leading to improved BBB integrity and protection from cognitive decline.

PI_NAMEs: BIX, GREGORY JAYE (contact);MILNER, D. RICHARD

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Adhesions;Age;age related;aged;Aging;Alzheimer's Disease;Animal Model;Animals;Arteriovenous malformation;Basement membrane;Behavior;behavior test;Binding Sites;Biochemical;Biological Assay;Blocking Antibodies;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;Brain;brain abnormalities;brain pericytes;Caspase;Cathepsins B;cell type;Cerebral Amyloid Angiopathy;Cerebral Infarction;cerebrovascular;Cerebrovascular Disorders;cerebrovascular pathology;Cerebrovascular system;Chronic;Cognitive;Consensus;Coupled;Data;Dementia;Development;Elderly;Endothelium;Excision;Exposure to;Extracellular Matrix;Extracellular Matrix Proteins;Female;glycosylation;Health;Heparan Sulfate Proteoglycan;Heparin Lyase;Heparitin Sulfate;Histologic;Human;hypoperfusion;Hypoxia;Immunofluorescence Immunologic;Impaired cognition;improved;In Vitro;in vivo;Integrin Binding;Integrins;Ischemic Stroke;Knockout Mice;Laminin;Length;male;Mediating;Methods;middle age;migration;Modeling;Modification;Molecular;mouse model;Mus;Nerve Degeneration;neuroprotection;Nitric Oxide Synthase;NOS3 gene;old mice;Outcome;overexpression;Pathogenesis;Pathologic;Peptide Hydrolases;Peptides;Pericytes;perlecan;Play;Population;prevent;Process;Proliferating;Proteolysis;receptor;Replacement Therapy;response;Role;sex;Side;Smooth Muscle Myocytes;Testing;Therapeutic;Time;Transgenic Mice;Up-Regulation;Vascular Dementia;vascular factor;white matter damage;Wild Type Mouse

PROJECT_TITLE: Investigating the Role and the therapeutic potential of Perlecan in experimental vascular dementia

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: DERMATOLOGY

PHR: PROJECT NARRATIVE Alopecia areata (AA) is one of the main dermatological disorders. With this project, we will study the mechanisms of the NKG2A pathway in AA and provide preclinical proof of concept for the treatment of AA using mouse model.

PI_NAMEs: CHRISTIANO, ANGELA M (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Acceleration;adaptive immune response;Agonist;Alopecia Areata;Antibodies;Antibody Therapy;Attenuated;attenuation;Autoimmune Diseases;Autoimmunity;Automobile Driving;Binding;C3H/HeJ Mouse;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Celiac Disease;Cell Physiology;Cells;Cellular Stress;chronic autoimmune disease;Clonal Expansion;common treatment;Data;Dermatologic;Development;Disease;Disease Progression;engineered T cells;Family;Gene Family;Genetic;Genetic Predisposition to Disease;Goals;Grant;Hair;Hair follicle structure;Histocompatibility Antigens Class I;Human;humanized mouse;immune activation;Immune response;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory Response;inhibitor;Innate Immune Response;innovation;insight;Insulin-Dependent Diabetes Mellitus;KLRD1 gene;Knockout Mice;Knowledge;Ligands;microbial;Modeling;mouse model;Multiple Sclerosis;Mus;Natural Killer Cells;Nature;novel;novel therapeutic intervention;overexpression;Pathogenesis;Pathogenicity;Pathway interactions;Play;pre-clinical;Qa-1 Antigen;receptor;Regulation;response;Rheumatoid Arthritis;Role;Signal Pathway;Signal Transduction;single cell analysis;single-cell RNA sequencing;Skin;T cell receptor repertoire sequencing;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;therapeutic target;Up-Regulation;Work;γδ T cells

PROJECT_TITLE: Targeting the NKG2A Pathway in Alopecia Areata

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: For Veterans and others with ALS, maintaining the ability to communicate is imperative. VA research is at the forefront of intracortical brain-computer interface technology (iBCI), an investigational neurotechnology that could improve independence for Veterans and others living with severe speech and motor impairments. iBCIs have enabled individuals with tetraplegia to use computers by thinking about the movement of their own hand, and to control point-and-click actions for on-screen typing, browsing the web and other familiar enabling activities. The main goal of this project is to provide Veterans and others living with paralysis or loss of speech with an intuitive iBCI-based communication interface that seamlessly enables both point-and-click computer interaction and high-performance multi-digit typing based on intended hand and finger movements.

PI_NAMEs: HOCHBERG, LEIGH R (contact)

PROJECT_TERMS: Address;Amyotrophic Lateral Sclerosis;Bilateral;brain computer interface;Calibration;Clinical Trials;Communication;Computer software;Computers;Data;Devices;Digit structure;digital;Electronic Mail;EP300 gene;Exhibits;Eye;Eye Movements;Family;Fatigue;finger movement;Fingers;Friends;Gestures;Goals;Hand;Head;Health Personnel;improved;Individual;Individuation;Industry Standard;innovation;Instruction;Interactive Communication;Internet;Intuition;Left;Machine Learning;Manuals;Methods;Modeling;Motion;Motor;Motor Cortex;motor impairment;Movement;Mus;neural;Neurons;neuroregulation;neurotechnology;neurotransmission;novel;Paralysed;Participant;Performance;Persons;Phase;Play;predictive modeling;Property;Quadriplegia;Research;restoration;Self-Help Devices;sensor;Signal Transduction;Speech;Speed;Spinal cord injury;Stroke;System;Tablets;Technology;Text Messaging;Thinking;Time;Upper Extremity;Variant;Veterans;Videoconferencing;virtual;web app;Work

PROJECT_TITLE: Rapid Neural Typing Interface for Veterans with ALS

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease;Precision Medicine;Prevention

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PUBLIC HEALTH RELEVANCE STATEMENT  Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease in the world, often leading to kidney failure, and there is no cure. Tolvaptan is the only FDA approved treatment, but its use is restricted to persons identified to be at risk of progression based on kidney size alone. Using a comprehensive panel of blood and urine tests the current project will improve the ability to identify persons at risk of rapid kidney disease progression who could benefit from tolvaptan treatment or inclusion in other treatment studies of ADPKD.

PI_NAMEs: GARIMELLA, PRANAV  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: antagonist;arm;Autosomal Dominant Polycystic Kidney;beta-2 Microglobulin;Biological Markers;Biological Specimen Banks;biomarker identification;biomarker panel;Blood;CCL2 gene;Chronic Kidney Failure;Classification;Clinical;clinical risk;Clinical Trials;Clinical Trials Design;cohort;Consumption;Cyst;Cystic kidney;Data;Dimensions;disease diagnosis;Disease Progression;Early identification;effective therapy;Enrollment;FDA approved;Fibrosis;Functional disorder;Future;General Population;Genetic;Glomerular Filtration Rate;Goals;Growth;Health;Heart failure;Height;high risk;high risk population;HIV;Image;Impairment;improved;Individual;Inflammation;Injury;Kidney;Kidney Diseases;Kidney Failure;Magnetic Resonance Imaging;Measures;Methods;Monitor;novel;Participant;Patients;Persons;Pharmaceutical Preparations;Phase;placebo controlled trial;Placebos;Populations at Risk;predicting response;predictive marker;Predictive Value;prognostic;prognostication;progression risk;public health relevance;Randomized;Renal function;Renal tubule structure;repaired;Risk;Risk Factors;risk stratification;Role;Severity of illness;side effect;targeted treatment;Testing;Time;tolvaptan;tool;Toxin;treatment effect;treatment response;trial comparing;Tubular formation;Urine;Validation;Vasopressin Receptor;Work

PROJECT_TITLE: Kidney Tubular Damage and Dysfunction in Autosomal Dominant Polycystic Kidney Disease


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Social Determinants of Health;Vaccine Related

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PROJECT NARRATIVE Leptospirosis is a neglected disease caused by a bacterium transmitted through contact with contaminated environmental sources such as soil and water, and a major cause of morbidity and mortality among residents of resource-poor countries and affects US residents engaging in water recreational activities, military personnel, and travelers to tropical destinations. Despite its public heath impact, no effective prevention is available. In this proposal we will characterize and evaluate a multi-recombinant protein construct that elicit cross protection against mortality and renal colonization—revealing immune B cell epitopes that can be use in a multi-epitope approach for a widely-applicable vaccine against leptospirosis.

PI_NAMEs: WUNDER, ELSIO AUGUSTO (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Address;Adsorption;Advanced Development;Affect;Amino Acids;Animal Experiments;Animal Model;Animals;Antibodies;Attenuated;Attenuated Vaccines;Awareness;B-Lymphocyte Epitopes;B-Lymphocytes;Bacteria;bactericide;Binding;Biological Assay;Cellular Immunity;Cessation of life;Characteristics;climate change;climate forcing;Clinical Trials;Communicable Diseases;Country;cross immunity;cross reactivity;Cryoelectron Microscopy;Data;Destinations;Developed Countries;Development;Disasters;Disease;Disease Outbreaks;disease transmission;Domestic Animals;economic impact;efficacy evaluation;Emerging Communicable Diseases;Environment;Environmental Pollution;Enzyme-Linked Immunosorbent Assay;Epitopes;Event;Experimental Animal Model;experimental study;farmer;Hamsters;Health;Health Benefit;Human;Humoral Immunities;Hurricane;Immune;Immune response;Immunity;Immunization;Immunize;immunogenic;immunogenicity;Immunology;improved;in silico;in vivo;Individual;Infection;inner city;Intervention;Investigation;Kidney;Knowledge;Leptospira;Leptospira interrogans;Leptospirosis;Life;Livestock;Maps;Mediating;Membrane Proteins;Methods;Military Personnel;Modeling;Morbidity - disease rate;mortality;Motility;multidisciplinary;Mus;mutant;neglect;novel;Order Spirochaetales;particle;Pathogenicity;Peptides;polyclonal antibody;Population;pre-clinical research;prevent;Prevention;Process;Productivity;Proteins;Proteome;Public Health;Puerto Rico;Rattus;Recombinant Proteins;Recombinants;Recreation;Research;research clinical testing;Research Personnel;Resolution;Resources;response;Risk;Serum;Slum;Soil;Source;Specificity;Sports;structural biology;Subunit Vaccines;Swimming;T cell response;T-Lymphocyte;Technology;Testing;transmission process;universal vaccine;Universities;Urbanization;Vaccinated;vaccine candidate;vaccine development;vaccine efficacy;vaccine strategy;vaccine-induced antibodies;Vaccines;Water;Western Blotting;Work;Zoonoses

PROJECT_TITLE: Development of a Universal Vaccine Against Leptospirosis

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NORTH CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

PHR: Project Narrative More than half of the world’s population is under the threat of Plasmodium infection that causes malaria. During and following COVID-19 the number of malarial cases and deaths have increased alarmingly, possibly due to the recalibrated efforts of healthcare systems to control the pandemic. The goal of our research is to identify and develop new immune-combinatorial therapies that improve function of immune cells that are critical for resistance to this globally important infection.

PI_NAMEs: VIJAY, RAHUL  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: acquired immunity;Affect;Anemia;Antibody Affinity;Antigens;Antiparasitic Agents;Automobile Driving;B-Lymphocytes;Binding;Biochemical;Blood;Bone Marrow;Calibration;CD4 Positive T Lymphocytes;cell type;Cells;Cessation of life;Chills;Clinical;Clinical Trials;combinatorial;Communicable Diseases;COVID-19;Cues;Data;Dengue;design;Disease;Epigenetic Process;Erythrocytes;Evaluation;Exercise;experimental study;Fever;Foundations;Functional disorder;functional improvement;Genetic;Genetic Transcription;Goals;Healthcare Systems;Hemolysis;Hemolytic Anemia;HIF1A gene;Humoral Immunities;Hypoxia;Immune;immune function;Immune response;immune stimulatory agent;Immunity;Immunologics;immunoregulation;Immunosuppression;Impairment;improved;Infection;Inflammatory;Interruption;Intervention;Life;Liver;Malaria;Mediating;Memory B-Lymphocyte;Metabolic;Metabolism;Modality;Modeling;Molecular;Molecular Target;Mosquito-borne infectious disease;Nutrient;pandemic response;Parasites;Parasitic infection;pathogen;Pathogenesis;Pathway interactions;Persons;pharmacologic;Phase;Phosphatidylserines;Physiological Processes;Plasma Cells;Plasmablast;Plasmodium;Play;Population;programs;Proliferating;prophylactic;Publishing;receptor;Reporting;Research;Resistance;response;Role;Signal Pathway;Signal Transduction;Structure of germinal center of lymph node;Testing;Therapeutic;transmission process;Trypanosomiasis;Vaccination;Work

PROJECT_TITLE: Role of TAM receptors in modulating humoral immunity against parasitic infections

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE This research study utilizes advanced bioinformatics and high-resolution spatial transcriptomics to identify social genomic mechanisms linking structural racism (SRD), perceived discrimination (PD), and aggressive breast cancer (BCa) blood and tumor biology as one explanation for why women living in historically redlined neighborhoods have worse BCa recurrence-free survival (RFS) outcomes, even after controlling for individual- level, tumor, and receipt of treatment factors. We will also utilize multiscale geographically weighted regression to identify neighborhoods associated with higher and lower risk-factors for shorter RFS, such as SRD, PD, aggressive biology, which will help us understand what low-risk regions are doing well, and subsequently what interventions can help promote longer RFS in high-risk regions.

PI_NAMEs: GOEL, NEHA  (contact)

PROGRAM_OFFICER_NAME: ACEVEDO, AMANDA MARIE

PROJECT_TERMS: Adjuvant Chemotherapy;Age;aggressive breast cancer;Air Pollution;anti-cancer research;Apoptosis;Basic Science;Behavior;Behavioral;Bioinformatics;Biological;Biology;Black race;Blood;Blood specimen;breast cancer genomics;Breast Cancer Patient;breast cancer progression;breast cancer survival;Cancer Biology;Cancer Center;cancer health disparity;cancer recurrence;Cells;Characteristics;Clinical;clinical effect;Cognitive;comorbidity;CREB1 gene;Data;defined contribution;Discrimination;Disparity;Epithelium;Ethnic Origin;fighting;Future;Gene Expression;Genetic Transcription;genomic epidemiology;Geography;Guidelines;Hematopoietic Neoplasms;high risk;Hispanic;Hospitals;Immune;immune activation;Immune response;improved;indexing;Individual;Infiltration;Inflammatory;Infrastructure;innovation;Intervention;Life Style;Link;Longitudinal cohort study;Macrophage;Malignant Breast Neoplasm;Maps;marginalized population;Mediating;Mediator;Mesenchymal;Modeling;Molecular Biology;Molecular Profiling;Myelogenous;National Comprehensive Cancer Network;neighborhood association;Neighborhoods;Neoadjuvant Therapy;Neoplasm Metastasis;neural;neurotransmission;Newly Diagnosed;NF-kappa B;Not Hispanic or Latino;novel;participant enrollment;Pattern;perceived discrimination;Perception;Policies;Pre-Clinical Model;Production;Propranolol;prospective;Prospective cohort;Prospective, cohort study;Race;Randomized, Controlled Trials;Recording of previous events;Recurrence;Regulation;research study;Resolution;response;Risk;Risk Factors;safety net;Signal Transduction Pathway;Sister;social;social adversity;social genomics;sociodemographics;stress management;Structural Racism;Surveys;survival disparity;survival outcome;Sympathetic Nervous System;Testing;Therapeutic;Therapeutic Intervention;Tissue Sample;transcription factor;Transcription Factor AP-1;transcriptomics;Treatment Factor;tumor;Tumor Biology;Up-Regulation;Variant;Woman

PROJECT_TITLE: Social Genomic Mechanisms Linking Structural Racism, Perceived Discrimination, and Breast Cancer Survival


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Prevention

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Non-alcoholic steatohepatitis (NASH) is is rapidly becoming the leading cause of liver disease in the developed world, with no effective treatment. We propose that mitochondrial genome molecules (mtDNA) released from fat- laden liver cells in NASH act as a “danger signal” which drive liver disease by causing scarring, and that detection of mtDNA in the blood can serve as a non-invasive biomarker of disease progression. We will perform mechanistic studies to decipher/elucidate the molecular pathways responsible for the pathogenic effects of mtDNA in the liver, with the aim of discovering much needed innovative therapies and diagnostic assays for NASH.

PI_NAMEs: POPOV, YURY  (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Alcoholic Hepatitis;Apoptosis;Automobile Driving;Bacteria;Bacterial DNA;Biological;Biological Assay;Biological Markers;Biopsy;Blood;cell injury;Cell Nucleus;Cells;Cicatrix;Country;Data;Deoxyribonuclease I;Detection;Diagnostic;diagnostic assay;Disease;Disease Progression;disorder control;Early Diagnosis;effective therapy;experimental study;extracellular;Fatty acid glycerol esters;Fatty Liver;fibrogenesis;Fibrosis;Genome;Goals;Hepatic Stellate Cell;Hepatocyte;hepatocyte injury;Human;Immune;Immune system;immunogenic;In Vitro;in vivo;Inflammation;inhibitor;Innate Immune Response;Innovative Therapy;Knock-out;Laboratories;Liver;Liver diseases;Liver Fibrosis;MAP3K5 gene;Maps;Measurement;Mediating;Membrane Potentials;Metabolic;Methodology;Mitochondria;Mitochondrial DNA;mitochondrial genome;mitochondrial membrane;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Nonesterified Fatty Acids;novel;Obesity;Organoids;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathogenicity;Pathway interactions;patient registry;Patients;Pattern;Phosphotransferases;Play;Preparation;prevent;Prevention;Resolution;response;Role;Sampling;Serum;Severity of illness;Signal Pathway;Signal Transduction;simple steatosis;Small Interfering RNA;Steatohepatitis;Stimulator of Interferon Genes;Structure;Testing;Therapeutic;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Mitochondrial DAMPs-driven Mechanisms of Liver Fibrosis in NASH

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative Tick-borne rickettsial diseases that cause human monocytic ehrlichiosis and human granulocytic anaplasmosis have become a growing public health concern for nearly four decades in the USA and many parts of the world. In this proposal, we propose to extend investigations that define genetics and host cell-free growth methods for two important pathogens: Anaplasma phagocytophilum and Ehrlichia chaffeensis. This will be valuable in advancing the understanding of pathogenesis, and the bacterial cellular and molecular interactions.

PI_NAMEs: GANTA, ROMAN R. (contact)

PROJECT_TERMS: Address;Agriculture;Anaplasma;Anaplasma phagocytophilum;Anaplasmataceae;Anaplasmosis;Animals;Bacteria;Binding;Biochemical;C-terminal;Canis familiaris;Cells;chronic infection;companion animal;Companions;Culture Media;Development;Disease;Ehrlichia;Ehrlichia canis;Ehrlichia chaffeensis;Ehrlichia ewingii;Ehrlichiosis;Evaluation;experimental study;Family;Foundations;Gene Deletion;Gene Mutation;Genes;Genetic;Genetic study;Genetic Transcription;Genome;Goals;granulocyte;Growth;Health;high risk population;Human;Hydrolase;Immunity;improved;In Vitro;in vivo;Infection;innovation;Investigation;knock-down;Libraries;member;Methods;microbial;Mitochondria;monocyte;Morbidity - disease rate;mortality;Mutagenesis;mutant;Mutation;Nature;Organism;Outcomes Research;pathogen;Pathogenesis;Pathogenicity;Persons;Phagosomes;Prevention;Protocols documentation;Public Health;Publishing;Research;Rickettsia;Rickettsia Infections;Rickettsiaceae;South America;Standardization;success;Supporting Cell;System;therapeutic development;tick-borne;tick-borne pathogen;Ticks;tool;vaccine development;vector;Vertebrates

PROJECT_TITLE: Genetics and Axenic Growth of tick-borne E. chaffeensis and A. phagocytophilum

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: TDP-43 is a protein that plays a role in Alzheimer's disease (AD) and other neurodegenerative disorders, but its involvement is not yet fully understood. Tau, another protein associated with neurodegenerative diseases, has been found to be comorbid with TDP-43 pathology. The aim of this proposal is to investigate the interaction between TDP-43 and Tau and to determine the consequences of their functional relationship, with the goal of identifying targetable molecular features that will yield uniquely superior therapeutics that outperform the current inadequate treatment options.

PI_NAMEs: KHANNA, MAY  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Address;Affinity;Aging;aging related;Alzheimer's Disease;Alzheimer's disease therapeutic;Amino Acids;Apoptosis;Automobile Driving;axon injury;Behavior;Binding;Biological Assay;Biology;biophysical properties;Biophysics;Brain;comorbidity;Cryoelectron Microscopy;Development;Disease;disease model;Disease Progression;fly;Generations;Genetic;Goals;Human;imaging study;Immunoprecipitation;In Vitro;in vivo;in vivo evaluation;Inflammation;innovation;Intervention;Knock-in;Knowledge;life span;Locomotion;Mass Spectrum Analysis;Measures;Methodology;mimetics;Modeling;Modification;Molecular;nanomolar;Nerve Degeneration;Neurodegenerative Disorders;neuropathology;neurophysiology;next generation;normal aging;novel;novel therapeutic intervention;overexpression;Pathologic;Pathology;Peptides;Persons;pharmacologic;Phenotype;Phosphorylation;physiologic model;Physiological;Play;Population;protein complex;protein protein interaction;protein TDP-43;Proteins;Role;small molecule;Surface Plasmon Resonance;synergism;synthetic peptide;tau interaction;tau Proteins;tau-1;Techniques;Testing;Therapeutic;three dimensional structure;Toxic effect;Transgenic Organisms;Traumatic Brain Injury;Vacuole;Work

PROJECT_TITLE: Biophysical and Pathophysiological Studies of TDP-43/Tau Interaction

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project narrative Primary tauopathies have no fluid or imaging biomarkers to track the disease during life. We will define when and which forms of tau proteins change during disease progression in familial and sporadic primary tauopathies. If we find primary tauopathy biomarkers that can stage the disease, it can help with early diagnoses and clinical trial designs.

PI_NAMEs: SATO, CHIHIRO  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Acceleration;accurate diagnosis;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Antibodies;Asian population;Autopsy;autosome;Binding;Biological Assay;Biological Markers;Brain;Brain Pathology;Brain region;brain volume;Caucasians;Cerebrospinal Fluid;Clinical;clinical application;clinical diagnosis;Clinical Treatment;Clinical Trials;Clinical Trials Design;Control Groups;corticobasal degeneration;corticobasal syndrome;Dementia;Development;Diagnosis;Disease;Disease Progression;drug efficacy;Early Diagnosis;Eligibility Determination;ethnic difference;Evolution;Frontotemporal Lobar Degenerations;Functional disorder;Goals;imaging biomarker;Immunohistochemistry;improved;Individual;Inherited;Knowledge;Life;Light;Liquid substance;Mass Spectrum Analysis;Measures;Medicine;Microtubules;Modeling;Mutation;mutation carrier;Nerve Degeneration;neurofilament;neuropathology;Neuropsychology;Pathology;Patients;Phosphorylation;Pick Disease of the Brain;Population;Progressive Supranuclear Palsy;Protein Isoforms;protein metabolism;racial difference;Research;Senility;simulation;Staging;Surrogate Markers;Symptoms;Syndrome;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Translating

PROJECT_TITLE: Staging primary tauopathies with tau proteoforms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: RALEIGH

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: This technology development project will demonstrate feasibility of a significant – by one to two orders of magnitude – increase in sensitivity of pulse EPR methods to study biomacromolecules at low concentrations. The approach is centered on the development of a radically new line of high volume / high quality factors resonators that are based on photonic band crystals adapted for operation in the mm-wave frequency range. If successful, the proposed approach will greatly expand the applicability of pulse EPR methods to basic and applied research in the fields of biochemistry and structural biology.

PI_NAMEs: NEVZOROV, ALEXANDER A.;SMIRNOV, ALEX I. (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: 2,4-Dinitrophenol;Amplifiers;Anisotropy;Applied Research;Basic Science;Biochemical;Biochemistry;Biological Models;biomacromolecule;Biomedical Research;biophysical tools;Biophysics;comparative;Complex;cost;Coupling;cryogenics;cryostat;Custom;design;design and construction;Development;Diameter;digital;Electron Nuclear Double Resonance;electron nuclear double resonance spectroscopy;Electron Spin Resonance Spectroscopy;Electronics;Electrons;experimental study;Extremely High Frequency Radio Waves;finesse;Frequencies;Future;Goals;heterodyning;improved;innovative technologies;instrumentation;Ions;Magnetism;Measurement;Measures;Membrane;metalloenzyme;Metals;Methods;microwave electromagnetic radiation;Modeling;Modernization;Motion;Myoglobin;new technology;NMR Spectroscopy;Noise;Nuclear;Oligonucleotides;operation;Oxygen;Peptides;photonics;Physiologic pulse;prevent;Protein Structure Initiative;Proteins;prototype;Publishing;quantum;Relaxation;Research;Rhodopsin;Sampling;scale up;Series;Signal Transduction;Site;Solid;solid state;Spectrum Analysis;Spin Labels;structural biology;Structure;System;Techniques;Technology;technology development;Temperature;Testing;Time;tool;two-dimensional;Validation

PROJECT_TITLE: Large-Volume Dielectric Resonators for mm-Wave Pulsed EPR

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Genetics;HIV/AIDS;Human Genome;Patient Safety

PHR: Project Narrative The Vanderbilt-Nigeria Research Ethics Training Program (V-NET) will build on our strong, decade-plus-long Vanderbilt University Medical Center (VUMC)-Aminu Kano Teaching Hospital/Bayero University Kano (AKTH/BUK) partnership and our highly successful, collaborative, and rapidly expanding portfolio of NIH- funded research and training in Nigeria. V-NET will develop a new Master of Science degree program in research ethics at BUK that involves didactic courses in addition to skills development, mentoring, and practicum experiences to build capacity for the ethical design, conduct, and oversight of genetic and genomic research in Nigeria. Through a series of collaborative educational efforts at AKTH/BUK and VUMC, V-NET will create a cadre of academics, researchers, health professionals and institutional review board members who will provide future leadership in the ethical design and review of research in the rapidly developing field of genetic and genomic research in Nigeria.

PI_NAMEs: ALIYU, MUKTAR HASSAN (contact);GORDON, ELISA J;ILIYASU, ZUBAIRU

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Academic Medical Centers;Address;Adult;Africa;Africa South of the Sahara;African;Bioethics;Child;Chronic Kidney Failure;cohort;Collaborations;community advisory board;Consultations;Country;Data;data privacy;Degree program;design;Development;Disclosure;Education;Educational workshop;Ethical Review;Ethics;Ethics Consultation;experience;Faculty;Funding;Future;Genetic;Genetic Counseling;Genetic Risk;genetic testing;genomic predictors;Genomics;Genotype;global health;Grant;Health;Health Professional;HIV;human subject protection;Incidental Findings;Informed Consent;innovation;Institution;Institutional Review Boards;interest;Kidney Diseases;Knowledge;Leadership;Master of Science;member;Mentors;Mentorship;Morbidity - disease rate;mortality;Nigeria;Nigerian;Organ;Output;Participant;Patients;personalized medicine;Persons;Positioning Attribute;precision medicine;prevent;Process;programs;Protocols documentation;Research;research and development;Research Ethics;Research Ethics Committees;Research Institute;Research Personnel;research study;Rights;Risk Factors;Sampling;Scientist;Series;Services;skill acquisition;skills;social culture;Societies;Status Epilepticus;Students;Teaching Hospitals;Technology;Test Result;Training;training opportunity;Training Programs;United States;United States National Institutes of Health;Universities;webinar;welfare

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-E (50)]


ORG_CITY: CHICAGO

ORG_NAME: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB

ORG_STATE: IL

PHR: Project Narrative: This project aims to improve recovery from Phrenic Neuropathy, a neuromuscular condition that impairs the diaphragm muscle, causing breathing difficulties that lead to disability. Our team plans to use Therapeutic Electrical Stimulation, a method emerging as a clinical strategy to speed up nerve regrowth, delivered via a novel, wireless and bioresorbable implant. The main hypothesis is that this Therapeutic Electrical Stimulation protocol, via enhanced Brain-Derived Neurotrophic Factor (BDNF) signaling in motor neurons, will accelerate the nerve regrowth and reconnection to the diaphragm muscle and improve recovery from Phrenic Neuropathy.

PI_NAMEs: FRANZ, COLIN  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acceleration;activating transcription factor 1;Acute;Address;Admission activity;Alleles;Axon;axon injury;axon regeneration;Back;Brain-Derived Neurotrophic Factor;Breathing;Clinic;Clinical;clinical implementation;clinical translation;Clinical Trials;clinically relevant;Collaborations;Complex;CREB1 gene;Custom;Data;design;Diagnostic tests;diagnostic value;disability;Dose;Effectiveness;Electric Stimulation;Electric Stimulation Therapy;Electrophysiology (science);Exertion;experimental study;Frequencies;functional improvement;gain of function;Genes;Growth;Head and Neck Neoplasms;Hindlimb;Hospitals;Hour;Human;Impairment;Implant;improved;In Situ Hybridization;Incidence;Individual;insight;Knock-in;Length;Life;Link;loss of function;Measurement;Mechanical ventilation;Methods;Modeling;Motor Neurons;mRNA Expression;multidisciplinary;Muscle;Muscle Fibers;Muscle function;muscle reinnervation;Natural regeneration;Nature;Nerve;nerve injury;nerve repair;nerve supply;Neuromuscular conditions;Neuromuscular Junction;Neurons;Neuropathy;Neurotrophic Tyrosine Kinase Receptor Type 2;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Patients;Performance;Peripheral;peripheral nerve repair;Persons;Phosphorylation;Phosphotransferases;Placebos;pressure;Protocols documentation;Public Health;Quality of life;Randomized, Controlled Trials;Rat Transgene;Rattus;reconstruction;Recovery;Recovery of Function;reinnervation;repaired;Reporting;Research;Research Proposals;respiratory;Respiratory Diaphragm;Respiratory Failure;Respiratory physiology;Rodent;Safety;SARS-CoV-2 infection;sciatic nerve;sciatic nerve injury;severe COVID-19;Shortness of Breath;Signal Transduction;Speed;Structure of phrenic nerve;success;Surgeon;Symptoms;Testing;Therapeutic Effect;Therapeutic Uses;Translating;Trauma;ultrasound;Up-Regulation;Western Blotting;wireless;Work

PROJECT_TITLE: Therapeutic Electrical Stimulation Using Wireless, Resorbable Implants to Accelerate Diaphragm Muscle Reinnervation after Phrenic Neuropathy


NIH_SPENDING_CATS: Aging;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: MAYAGUEZ

ORG_NAME: UNIVERSITY OF PUERTO RICO MAYAGUEZ

ORG_STATE: PR

PHR: Narrative: Several investigators from the Departments of Chemistry, Biology, Engineering, and Material Science with biomedical science applications in western and southern Puerto Rico are seeking funding to acquire a Cytation 5 Imaging Multi-Mode Reader. This instrument would provide combined image reading and absorbance/fluorescence/luminescence reading capabilities, enabling research that is currently unsupported by existing equipment. The acquisition of this instrument would allow for time-sensitive and more complex screening assays to analyze biochemical and cell-based activities in 96 or 384 well plates. Additionally, it would facilitate high- throughput image-based analysis of live cells in real-time, leading to faster progress toward our project goals. The Cytation 5 Imaging Multi-Mode Reader would greatly enhance our ability to perform advanced research, expanding the scope of our investigations and enabling us to gather critical data that was previously inaccessible. With its versatile capabilities, we anticipate significant advancements in our understanding of biomedical science and accelerated progress in achieving our research objectives.

PI_NAMEs: CARMONA, JOSE A (contact)

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: Area;Biology;Biomedical Research;Chemistry;Community Health Education;cytate;Data;Data Analyses;Detection;digital;Disease;Engineering;Ensure;Equipment;equipment acquisition;Faculty;Fluorescence;Future;Gases;high throughput screening;Image;imaging system;Incubators;Institution;instrument;Link;live cell imaging;luminescence;Maintenance;member;Microscope;microscopic imaging;Microscopy;Minor;Modality;next generation;Phenotype;Procedures;programs;Puerto Rico;Reader;Research;Research Personnel;Resources;Science;Scientist;Technology;Temperature;three dimensional cell culture;Time;Training;undergraduate student;Universities;user-friendly

PROJECT_TITLE: Cytation 5 Multimode Imaging System for UPR at Mayaguez Biomolecular Chemistry Facilities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (30)]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Injury - Accidents and Adverse Effects

ORG_CITY: GLASSBORO

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: ROWAN UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Surgery to treat femur fractures is difficult as surgeons must manually apply large forces to align the broken bone fragments with limited visual feedback. Complications are frequent, including high rates of malalignment, reoperations, and mortality in the elderly. This research will develop an image-guided surgical robotic system for femur fracture surgeries that will assist the surgeon by providing sufficiently large traction forces and precise intuitive control to automatically align the bone fragments with real-time tracking of the bone.

PI_NAMEs: ABEDIN NASAB, MOHAMMAD  (contact);IORDACHITA, IULIAN IOAN

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: 3-Dimensional;aging population;Algorithms;American;arm;bone;bone imaging;Cadaver;Clinical;Complication;Computer software;Death Rate;design;Distal;Elderly;experience;Exposure to;Feedback;Femoral Fractures;Femur;force feedback;force sensor;Fracture;Fracture Fixation;Freedom;Future;Gait abnormality;graphical user interface;grasp;Hand;haptic feedback;haptic interface;haptics;Hemorrhage;Hospital Costs;Image;image guided;image registration;Image-Guided Surgery;Immobilization;improved;In Situ;infection risk;Injury;innovation;Interdisciplinary Study;Intuition;Leg;Legal patent;Length;Length of Stay;Location;long bone;Manuals;Measurement;Methods;millimeter;mortality;Motion;Movement;Multiple Fractures;Muscle;Navigation System;novel;operation;Operative Surgical Procedures;Optics;Orthopedics;Outcome;Patient-Focused Outcomes;Patients;Performance;Persons;Positioning Attribute;prevent;Procedures;Radiation;Repeat Surgery;Research;Risk;Robot;robotic system;Robotics;Roentgen Rays;sample fixation;Scanning;simulation;skills;soft tissue;Speed;Surgeon;System;Technology;Testing;Three-Dimensional Image;three-dimensional modeling;three-dimensional visualization;Time;Torque;Traction;Training;Translational Research;Tremor;United States;usability;virtual;virtual reality simulator;virtual surgery;Visual;visual feedback;Work;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: Image-Guided Surgical Robotic System for Femur Fracture Reduction

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ORG_CITY: Los Angeles

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative – Molecular basis of complement anaphylatoxin receptor activation, regulation, selectivity and signaling bias. This research proposal aims to uncover the molecular mechanisms underlying complement anaphylatoxin receptor activation, regulation, selectivity, and signaling bias. By investigating these aspects, we will gain a comprehensive understanding of anaphylatoxin signaling, which could lead to the development of novel tool and therapeutic compounds for a range of diseases, associated with aberrant complement cascade activity.

PI_NAMEs: GATI, CORNELIUS  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;Agonist;Alzheimer's Disease;Anaphylatoxins;Anaphylaxis;antagonist;Arginine;Asthma;Autoimmune Diseases;Automobile Driving;beta-arrestin;Binding;Biochemical;Biological Assay;Biology;C3AR1 gene;C5AR2 gene;Calcium;cell injury;Communities;Complement;Complement 3a;Complement 5a;Complement Activation;Complement Receptor;complement system;Complex;Couples;Coupling;Cryoelectron Microscopy;cytokine;Data;Development;Disease;Drug Design;drug discovery;Family;Functional disorder;Future;G-Protein-Coupled Receptors;Goals;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;Human;Immune response;Immune system;immunoregulation;Inflammation;Innate Immune System;insight;Investigation;Knowledge;Lead;Length;Ligands;Link;Lupus;Malignant Neoplasms;MAPK3 gene;Mediating;Microbe;Modification;Molecular;Molecular Conformation;Multiple Sclerosis;Mus;N-terminal;Nerve Degeneration;Neurodegenerative Disorders;novel;Organism;Parkinson Disease;pathogen;Pathway interactions;Pattern;Peptide Receptor;Peptides;Pharmacodynamics;Phosphotransferases;Physiological;Physiology;Plasma Proteins;Positioning Attribute;Process;Production;rational design;receptor;Receptor Activation;receptor binding;receptor function;Receptor Signaling;recruit;Regulation;Regulatory Pathway;Research;Research Proposals;Resolution;Rheumatoid Arthritis;Role;Sepsis;Series;Signal Transduction;Signaling Protein;Structure;synthetic peptide;System;targeted treatment;Techniques;Therapeutic;therapeutic development;Therapeutic Effect;Therapeutic Intervention;tool;tool development;Transducers;Work

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE The proposed research uses novel technology to detect leukemia at low levels after transplantation and inform potential next steps in therapy. This work is relevant to public health because understanding how to more effectively direct patients with relapsed leukemia to appropriate treatment after transplantation will lengthen their lives and potentially cure them of disease.

PI_NAMEs: FURLAN, SCOTT NICHOLAS (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, LOKESH

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;Address;adverse outcome;Algorithms;Alleles;Allogenic;Antigen Presentation Pathway;Biological Assay;burden of illness;cancer cell;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chemoresistance;Chimerism;Classification;Clinical;clinically actionable;cohort;Computational algorithm;Computing Methodologies;Custom;Data;Detection;detection limit;detection method;detection sensitivity;Diagnostic;Disease;disease-causing mutation;disorder risk;Down-Regulation;Dysmyelopoietic Syndromes;Epitopes;Exhibits;experimental study;Flow Cytometry;Future;Gene Combinations;Gene Expression;Genes;Genetic;Genetic Variation;Genomics;Goals;Hematopoietic Stem Cell Transplantation;Heterogeneity;high risk;human leukocyte antigen testing;Immune;Immune Evasion;Immune system;Immunophenotyping;improved;In Vitro;indexing;insight;leukemia;leukemia initiating cell;leukemia relapse;Leukemic Cell;Loss of Heterozygosity;Measurable;Measurement;Measures;Methodology;Methods;Molecular;Molecular Profiling;Molecular Target;Myeloproliferative disease;new technology;novel;Outcome;Pathway interactions;patient stratification;Patient Triage;Patient-Focused Outcomes;Patients;post-transplant;pre-clinical;Public Health;Recurrent disease;Regimen;Relapse;relapse prediction;relapse risk;Research;Residual Neoplasm;Risk Assessment;risk stratification;RNA;Role;Sampling;sequencing platform;single cell genomics;single-cell RNA sequencing;Supportive care;Surface;Surveillance Methods;System;Technology;Testing;Therapeutic;transcriptome;Transplant Recipients;Transplantation;treatment response;Variant;Work

PROJECT_TITLE: A compass for those with relapsed leukemia after transplant

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pain Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This study aims to investigate how top-down brain networks influence pain processing using direct intracranial brain recordings during chronic pain and pain relief. It will explore the interaction between ascending and descending circuits and examine the influence of emotion and expectation on pain perception. The findings will contribute to understanding the underlying mechanisms of chronic pain and may inform new approaches for pain diagnosis and treatment.

PI_NAMEs: SHIRVALKAR, PRASAD  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Acute Pain;Address;Affective;analog;Animals;Anterior;Anxiety;Basal Ganglia;Bilateral;Biological Markers;Brain;Brain region;Chronic;Chronic intense pain;chronic pain;chronic pain management;chronic pain patient;chronic painful condition;cingulate cortex;Clinical Trials;clinically relevant;Clip;Cognitive;cognitive control;cognitive process;Communication;Complex;Cues;Data;Deep Brain Stimulation;Development;Diagnosis;diagnostic tool;Dimensions;effective therapy;Electrodes;Electroencephalography;Emotional;Emotions;Environment;Evoked Potentials;expectation;experience;Fright;Functional Magnetic Resonance Imaging;Graph;graph theory;gray matter;Happiness;Home;Hour;Human;Implant;Implanted Electrodes;improved;Insula of Reil;Knowledge;Laboratories;McGill Pain Scale;Measurement;Measures;Medial;Mediating;millisecond;Moods;movie;Nature;network models;neural;Nociception;novel diagnostics;novel strategies;Pain;pain perception;pain processing;pain relief;pain symptom;Participant;Pathway Analysis;Pathway interactions;Patients;Pattern;Physiology;Placebo Effect;Placebos;positive emotional state;positive mood;Prefrontal Cortex;prospective;recruit;Reporting;response;Role;Sensory;Signal Transduction;somatosensory;spatiotemporal;spontaneous pain;Stimulus;temporal measurement;Testing;Thalamic structure;theories;Therapeutic;trait;Ventricular;Visual

PROJECT_TITLE: Corticothalamic network function in chronic pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Aging;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE This proposal focuses on understanding why older people often suffer more severe liver damage from burns and finding new ways to treat and detect this damage early. Using state-of-the-art technology, we explore how burns may affect liver cell energy production, particularly in older individuals, leading to more damage and poor outcomes. Our project is primed to revolutionize the understanding and treatment of burn-related liver injuries, heralding the development of innovative medicines and diagnostic techniques that could notably augment survival rates and enhance overall health outcomes, especially in elderly individuals.

PI_NAMEs: IDROVO, JUAN PABLO (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acetylgalactosamine;Affect;Age;age related;age related changes;aged;Aging;Alanine Transaminase;Alkaline Phosphatase;Aspartate Transaminase;Attenuated;Bilirubin;Biological Markers;Blocking Antibodies;Burn injury;burn therapy;Burn Trauma;Caring;Cells;Clinical;clinical application;Complex;cytokine;Data;Death Rate;Development;Diagnosis;Diagnostic Procedure;diagnostic strategy;Early Diagnosis;effectiveness evaluation;efficacy testing;Elderly;Electron Transport;Exposure to;Foundations;Functional disorder;Gene Proteins;Genes;genome wide methylation;Genus Hippocampus;Goals;Health;Hepatic;Hepatocyte;Histology;Hour;Human;improved;In Vitro;in vivo;Individual;Indocyanine Green;Inflammation;Inflammatory;Inflammatory Response;innovation;Interleukin-1 beta;Intervention;knock-down;Knock-out;Knockout Mice;Link;Liver;Liver diseases;Liver Dysfunction;liver function;liver inflammation;liver injury;Measures;Medical;Medicine;Messenger RNA;Methods;Methylation;Mitochondria;mitochondrial metabolism;Mitochondrial Proteins;Modeling;Morbidity - disease rate;mortality;mRNA Expression;Mus;Necrosis;new therapeutic target;non-alcoholic fatty liver disease;novel;novel diagnostics;novel strategies;novel therapeutics;old mice;older adult;Older Population;Organ;Outcome;oxidative damage;Pathology;Patients;Polymerase Chain Reaction;Population;potential biomarker;Predisposition;Production;Prognosis;prognostic value;protein expression;Proteins;Prothrombin time assay;Research;Respiration;Respiration Disorders;response;Reverse Transcription;Role;Serum;Small Interfering RNA;Solid;stem;Structure;success;Survival Rate;Technology;Testing;Therapeutic;TNF gene;Transfection;treatment strategy;tumor;Up-Regulation;Vascular blood supply;Wild Type Mouse;Work

PROJECT_TITLE: Aging, Burn Trauma, and Liver Damage

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

PHR: Project Narrative The proposed basic research is relevant to public health because it focuses on a fundamental biomechanical interactions in lung cancer progression. The work will lay the foundation for the development of new strategies to prevent and treat lung cancer morbidity and mortality.

PI_NAMEs: MENDOZA, MICHELLE CHRISTINE;WEISS, JEFFREY A. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: adenoma;Aftercare;Alveolar;Alveolar wall;Alveolus;Area;Atomic Force Microscopy;Basic Science;Benign;Biochemical;Biological Markers;Biomechanics;Biosensor;Bleomycin;Cancer Etiology;cancer invasiveness;Cancer Patient;cancer recurrence;Cell Proliferation;Cessation of life;Clinical;Computer Models;Computer Simulation;Computer software;Data;Deposition;Development;digital;Elements;Environmental Exposure;epidemiologic data;Epithelial Cells;Exhibits;experience;Experimental Models;experimental study;Extracellular Matrix;Failure;Feedback;Fibrosis;Foundations;Goals;Growth;Histopathology;Immune response;In Situ;innovation;Invaded;Knowledge;Lesion;Lung;Lung Adenocarcinoma;Lung Adenoma;lung lesion;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Measures;mechanical signal;Mechanical Stress;Mechanics;Mediating;Metastatic Neoplasm to the Lung;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;Neoadjuvant Therapy;neoplastic cell;novel;novel strategies;open source;Patients;Periodicity;Phase;Phenocopy;physical property;premalignant;prevent;Process;Property;Public Health;Pulmonary Fibrosis;Reaction;repository;Research;Respiration;Risk;Role;Scientist;Signal Pathway;Signal Transduction;simulation;Slice;Solid Neoplasm;Specimen;Stretching;Structure of parenchyma of lung;Testing;therapeutic target;Three-Dimensional Image;Three-Dimensional Imaging;Tissues;Transgenic Mice;tumor;Tumor Burden;Tumor Expansion;tumor growth;tumor microenvironment;tumor progression;Work

PROJECT_TITLE: Mechanical Stress and Lung Tumor Progression

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Dental, Oral, and Craniofacial Disease;Genetics;Headaches;Human Genome;Migraine;Neurosciences;Pain Research;Sleep Research

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Pain is a universal human experience, and growing evidence indicates a close crosstalk between circadian rhythms and pain disorders including headaches; however, the underlying molecular mechanism is poorly understood. Based on our recent preliminary results from behavioral, omics and molecular studies, the current proposal aims to investigate the circadian clock function in rhythmic pain responses and delineate the mechanism of a novel circadian regulator of headache pain. This pioneering project will generate seminal functional and mechanistic insights toward understanding the temporal basis of pain, and promote development of new mouse models and chronotherapeutic strategies for headache and other pain disorders.

PI_NAMEs: BURISH, MARK J;YOO, SEUNG-HEE  (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Adverse effects;Affect;Applications Grants;ARNTL gene;Behavioral;behavioral study;Biological;Biological Markers;brain tissue;Cell Culture Techniques;Cells;Chronic;Chronotherapy;circadian;circadian biology;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;circadian transcriptome;Clinical;Cluster Headache;Development;disability;Disease;Drug Prescriptions;Drug usage;Environmental Impact;Ergotamine;Exhibits;experience;Feedback;Functional disorder;Future;Ganglia;Genes;Genetic;genome wide association study;Goals;Headache;Headache Disorders;Human;Hypothalamic structure;In Vitro;in vivo;inhibitor;innovation;insight;Intervention;Jet Lag Syndrome;Kinetics;Knockout Mice;Knowledge;Label;Life;Light;loss of function;Measures;Mechanics;Medical;MERTK gene;Migraine;Modeling;Molecular;molecular marker;mouse model;Mus;Neurotransmitters;Nitroglycerin;Nociceptors;novel;Outcome;Pacemakers;Pain;Pain Disorder;Pain management;pain sensitivity;Pain Threshold;Pathway interactions;Patients;Periodicity;Persons;Pharmaceutical Preparations;Pharmacogenetics;pharmacologic;Phosphorylation;Physicians;Protein Tyrosine Kinase;Proto-Oncogenes;Receptor Protein-Tyrosine Kinases;Regulation;Reporter;response;response biomarker;Role;Seminal;Signal Pathway;somatosensory;Structure of trigeminal ganglion;Suicide;suprachiasmatic nucleus;Susceptibility Gene;Syndrome;System;Testing;Time;Tissues;transcriptome;transcriptome sequencing;translational impact;Visit

PROJECT_TITLE: Regulation of headache pain responses by the Trigeminal ganglion clock

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

PHR: Project Narrative Trichomonas vaginalis is estimated to be the most common non-viral sexually transmitted infection worldwide (STI), causes considerable and costly perinatal/reproductive morbidity, and disproportionately affects persons of color; currently recommended treatment regimens have high breakthrough rates of infection. This proposal will examine the effectiveness and cost effectiveness of single-dose 2 g oral secnidzole compared to multi-dose oral metronidazole 500 mg twice daily X 7 days for the treatment of T. vaginalis in women and men. Results of this study will impact future Centers for Disease Control and Prevention STI Treatment Guidelines for T. vaginalis.

PI_NAMEs: KISSINGER, PATRICIA J (contact);MUZNY, CHRISTINA A

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: 4-nitroimidazole;Affect;arm;Bacterial Vaginosis;Brazil;breakthrough infection;Centers for Disease Control and Prevention (U.S.);Clinic;clinical diagnosis;co-infection;comorbidity;comparative cost effectiveness;cost;cost effective;cost effectiveness;Data;demographics;Direct Costs;Dose;effectiveness evaluation;Europe;Facilities and Administrative Costs;FDA approved;follow-up;Future;Goals;Half-Life;HIV;Home;improved;Infection;infection rate;Lactation;Literature;men;Metronidazole;Minority Groups;Natural History;next generation;open label;optimal treatments;Oral;Patients;people of color;Perinatal;perinatal outcomes;Persons;Pharmaceutical Preparations;Phase IV Clinical Trials;Placebos;preference;Pregnancy;Randomized;randomized trial;Recommendation;Reduce health disparities;Regimen;reproductive;reproductive morbidity;Resolution;Risk;sample collection;sex;Sexually Transmitted Diseases;STI prevention;televisit;Testing;transmission process;treatment choice;Treatment Cost;treatment duration;treatment effect;Treatment Effectiveness;treatment guidelines;Treatment Protocols;trial comparing;Trichomonas vaginalis;United States;Update;Visit;Woman;women's treatment;Women's trial

PROJECT_TITLE: Refining Trichomonas vaginalis treatment in women and men.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BROOKINGS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: SOUTH DAKOTA STATE UNIVERSITY

ORG_STATE: SD

PHR: PROJECT NARRATIVE We will fully develop a web-based tool (ShinyGO) to enable researchers to interpret results from genomics or proteomics studies. Although this tool has been used by tens of thousands of researchers, much work remains to be done to make it robust, interactive, and reproducible. This project will contribute to the understanding of various diseases at the molecular level.

PI_NAMEs: GE, XIJIN  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Acceleration;Adopted;Benchmarking;bioinformatics tool;Biological;biological research;biological systems;Cells;Characteristics;chatbot;ChatGPT;Chromosome abnormality;Classification;Code;Collaborations;Communities;Community Outreach;Complement;Computer software;Data;Data Set;Databases;Dedications;design;Developing Countries;Disadvantaged;Disease;Documentation;empowerment;Exons;experience;Funding;gene discovery;Gene Expression Regulation;Gene set enrichment analysis;Generations;Genes;Genome;genome annotation;Genomics;Goals;Graph;graph knowledge base;graphical user interface;Guanine + Cytosine Composition;improved;Institution;Internet;Investigation;knowledge base;knowledge graph;Length;Letters;Maintenance;Manuals;Maps;Medical Research;MeSH Thesaurus;Methods;MicroRNAs;Molecular;Monitor;Oncogenes;Ontology;open source;Organism;outreach;Paper;Pathway Analysis;Pathway interactions;Production;protein protein interaction;Proteins;Proteomics;prototype;Publishing;Reporting;Reproducibility;Research Personnel;Resources;RNA analysis;Science;Scientist;Semantics;Side;Surveys;System;Technology;Testing;Text;tool;Training;Transcript;transcription factor;transcriptome sequencing;transcriptomics;Trees;United States National Institutes of Health;Untranslated Regions;Update;user-friendly;Visit;Visualization;web app;web page;web site;web-based tool;Work;X Chromosome

PROJECT_TITLE: An interactive and reproducible tool for enrichment analysis

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PHR: NARRATIVE The goal of this project is to develop a novel method of vaccine delivery through the oral cavity mucosa using a vaccine coated floss. By developing this approach, it may be possible to generate mucosal and systemic immunity. The use of a floss is painless and child friendly, therefore, this new method of vaccination could have a strong impact on public health and vaccination campaigns.

PI_NAMEs: GILL, HARVINDER SINGH (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Anatomy;Animal Model;Antigens;base;bone;bone cell;Cells;Child;Clinic;Cold Chains;Data;Dental;Deposition;Desmosomes;Devices;Distal;Distant;Environment;Epithelial Attachment;Epithelial Cell Junction;Epithelial Cells;Epithelium;Family suidae;Friends;gastrointestinal;Genetic;Gingiva;Goals;Government;HIV;Human;Immune;Immune response;Immunity;Immunization;Immunologic Stimulation;Incisor;Infection;Influenza;influenza virus strain;influenzavirus;Injections;Intestinal Mucosa;Lung;Methods;mouse model;Mucosal Immunity;mucosal vaccination;Mucous Membrane;Mus;Nature;Needles;novel;novel strategies;Oral cavity;Oral mucous membrane structure;Outcome;Ovalbumin;Pain;Painless;pathogen;Permeability;Persons;Population;Process;Property;Public Health;Reproducibility;Research;Research Proposals;Respiratory Mucosa;Route;Site;Solid;Stomach;Surface;Technology;Testing;Tight Junctions;Tissues;Tooth structure;trafficking;Translating;translational potential;Vaccination;Vaccine Antigen;vaccine delivery;Vaccines;Vagina;vaginal mucosa;Viral Antigens;Work

PROJECT_TITLE: Floss: a novel method for oral mucosal vaccination

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]