NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE The microbiome is composed of the beneficial microbes in the gastrointestinal tract that play a role in maintaining gut health. The proposed work will investigate the mechanisms by which a microbe-generated metabolite, Valerobetaine (VB), alters colonic epithelial cell metabolism and identify the effect of VB on intestinal tissue health. A better understanding of the roles and mechanisms of microbe-generated metabolites can allow for their utilization as therapeutic options in the treatment of disorders such as Inflammatory Bowel Disease.

PI_NAMEs: ASKEW, LAUREN CASEY (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: 3-Dimensional;Affect;Animals;beneficial microorganism;Bioenergetics;Biogenesis;Biology;Biopsy;Body System;Carnitine;Cell Proliferation;Cells;Cellular Metabolic Process;Chronic;Colitis;Colon;Colonoscopes;commensal bacteria;Communication;Complex;Data;Development;Disease;Energy Metabolism;Epithelial Cells;Epithelium;Etiology;Event;Experimental Models;Family;fatty acid oxidation;Forcep;Foundations;Functional disorder;functional plasticity;Gastroenterology;Gastrointestinal Diseases;gastrointestinal epithelium;Gastrointestinal tract structure;Gene Expression;Generations;Germ-Free;Gnotobiotic;Goals;Grant;gut health;gut homeostasis;gut inflammation;gut microbiome;gut microbiota;Health;Hepatocyte;Homeostasis;host microbiome;Immune response;In Vitro;in vivo;Indoles;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;interest;intestinal crypt;intestinal epithelium;Intestines;Knowledge;Leaky Gut;Maintenance;Mass Spectrum Analysis;Mediating;Metabolism;metabolomics;Methodology;Methods;Microbe;microbial;microbiome;microbiome composition;microbiota;microorganism antigen;Mitochondria;mitochondrial metabolism;Modeling;Modification;Molecular;Morbidity - disease rate;mouse model;murine colitis;Mus;novel;Organoids;Persons;Phenotype;Physiology;Play;preservation;Proliferating;Quality of life;Research;response;Risk Factors;Role;Science;Scientist;Signal Pathway;small molecule;stem cell niche;Testing;Therapeutic;therapeutic target;Tissues;Training;Volatile Fatty Acids;Work;Wound models

PROJECT_TITLE: Valerobetaine is a microbe-generated metabolite that induces mitochondrial biogenesis and maintains epithelial integrity


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The consequences of sugar overconsumption in America are clear: two-thirds of Americans suffer from diet- related chronic illnesses including obesity and diabetes. Specialized sensory cells in the intestine, called neuropod cells, drive sugar appetite. The proposed studies will define the receptor required for neuropod cell sugar sensing, revealing a novel pharmaceutical target for downregulating sugar appetite.

PI_NAMEs: ALWAY, EMILY JEAN (contact)

PROJECT_TERMS: absorption;Adult;Agonist;American;Anti-diabetic Drugs;Bariatrics;Binding;Brain;brain control;Cardiovascular Diseases;career;Cells;Chronic Disease;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;comorbidity;Consumption;COVID-19;Data;Desire for food;detection of nutrient;Diabetes Mellitus;Diet;Doctor of Medicine;Doctor of Philosophy;Electrophysiology (science);Energy Metabolism;Epithelial Cells;Family;Food;glucose transport;Glucose Transporter;Glutamates;Goals;Health;hormonal signals;Hospitalization;Human;In Vitro;in vivo;inhibitor;Intake;Intervention;intestinal epithelium;Intestines;Knock-out;Leadership;Life;Ligands;Measures;Mediating;Membrane Proteins;Mentors;Mentorship;Metabolism;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Neurobiology;neurogenetics;Neurons;Nitrogen;novel;Obesity;Organoids;Oxygen;Perfusion;pharmacologic;Pharmacologic Substance;Physicians;Positioning Attribute;receptor;Recommendation;response;Role;Scientist;sensor;Sensory;Signal Transduction;skills;Sodium;Structure;sugar;Testing;Therapeutic;Time;Training;Transcript;Vagus nerve structure

PROJECT_TITLE: Rapid sugar sensing from gut to brain


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Digestive Diseases;Genetics;Infectious Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Recent studies have demonstrated that the levels of C. albicans and C. tropicalis are significantly higher in Crohn’s disease (CD) patients than in their non-diseased relatives. These human data, coupled with our findings that Candida-infected C57BL/6 (B6) mice are more susceptible to chemically-induced colitis compared to uninfected controls, strongly suggest that Candida infections may play a role in triggering flares during CD and that antifungal therapy may be beneficial in CD patients. Due to the rising public health burden from inflammatory bowel diseases, a more thorough understanding of ways in which candidiasis affect the gut microbiome and consequently immune responses is of critical importance.

PI_NAMEs: DI MARTINO, LUCA  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Affect;Antibiotics;Antifungal Therapy;antimicrobial;Bacteria;Biological;Blocking Antibodies;C57BL/6 Mouse;Candida;Candida albicans;Candida tropicalis;Candidiasis;chemically induced colitis;Colitis;Colonoscopy;commensal microbes;Communities;Complex;Coupled;Crohn's disease;Data;design;Development;dextran sulfate sodium induced colitis;Disease remission;dysbiosis;Etiology;experimental group;experimental study;First Degree Relative;Flare;Flow Cytometry;Functional disorder;Gastrointestinal tract structure;Gene Expression;Genes;Genetic;germ free condition;Germ-Free;Goals;gut inflammation;gut microbiome;Health Hazards;Histology;Human;human data;IL17 gene;Ileitis;Immune response;Immunocompromised Host;improved;In Vitro;in vivo;Individual;Infection;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Intestines;Intraperitoneal Injections;Knowledge;Link;Lymphocyte;Mediating;mesenteric lymph node;Metagenomics;Microbe;microbiome alteration;microbiome composition;Molecular;mouse model;Mucins;Mus;mycobiome;Mycoses;nano-string;novel;Outcome Measure;pathogenic fungus;Patients;Phenotype;Population;Predisposition;Public Health;Resources;response;Ribosomal RNA;Role;Ruminococcus;Saccharomycopsis;SAMP mouse;side effect;Sodium Dextran Sulfate;stool sample;T-Lymphocyte Subsets;Testing;Yeasts

PROJECT_TITLE: The Intestinal Mycobiome and IBD

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Narrative The focal point of this project is to decode the cellular and molecular mechanisms that drive infiltration of glioblastoma (GBM), which is a major cause of recurrence and contributes to the high mortality rate of this disease. We propose to uncover how the activity of subsets of neurons contributes GBM infiltration, while also examining the roles of axon guidance genes in GBM infiltration. These studies will reveal new cellular and molecular mechanisms that control the infiltration and invasion of GBM that are likely to be applicable to other forms of brain tumors and also other types of tumors that metastasize to the brain.

PI_NAMEs: DENEEN, BENJAMIN  (contact);RAO, GANESH

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: Adult;Automobile Driving;axon guidance;Biology;Brain;Brain Neoplasms;brain parenchyma;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;chemokine receptor;chemotherapy;Clinical;clinical investigation;cohort;Contralateral;Corpus Callosum;Death Rate;Diagnosis;Diffuse;Disease;Excision;excitatory neuron;Functional disorder;Gene Combinations;Gene Expression;Genes;Genetic;genetic manipulation;Glioblastoma;Goals;human disease;Hyperactivity;Immune;Immune response;Infiltration;inhibitory neuron;Invaded;Journals;Knock-out;Knowledge;Laboratories;Link;Malignant - descriptor;migration;Modeling;Molecular;mouse model;Mus;Nature;Neoplasm Metastasis;neoplastic cell;Neurons;novel;novel therapeutic intervention;Operative Surgical Procedures;overexpression;Pathogenesis;Play;Population;Primary Brain Neoplasms;Primary Neoplasm;Radiation;Recurrence;response;Role;single-cell RNA sequencing;Site;Survival Rate;transcriptomics;tumor;Tumor Cell Migration;tumorigenesis;white matter

PROJECT_TITLE: Cellular and Molecular Mechanisms of GBM Infiltration

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Immunotherapy;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative Malaria is caused by Plasmodium, a parasite that is spread by mosquitoes, and the disease is often characterized by a high fever and other flu-like symptoms. The disease affects all organs of the body and can cause a heightened immune response that can lead to death; the World Health Organization reported that in 2017 there were ~435,000 deaths due to malaria. To better treat and prevent malaria, the goal of this proposal is to understand how the body’s immune system detects Plasmodium and identify the genes and pathways responsible for responding to and eliminating this parasite.

PI_NAMEs: FITZGERALD, KATHERINE A.;GOLENBOCK, DOUGLAS T (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: 3-Dimensional;Acute;acute infection;Affect;AIM2 gene;Anemia;Animal Model;Antigen-Antibody Complex;ATAC-seq;Bacterial Infections;base;Brazil;Cell Culture Techniques;Cell Nucleus;Cells;Cerebrum;Cessation of life;Chromatin;chromatin modification;Clinical;Culicidae;cytokine;Cytokine Gene;cytokine release syndrome;Data;defined contribution;detection platform;Disease;DNA;DNA-Binding Proteins;ds-DNA;Epigenetic Process;epigenetic regulation;Exposure to;Falciparum Malaria;Fever;flu;Funding;gain of function;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;Goals;Grant;Heme;hemozoin;Human;Immune;immune activation;Immune response;Immune Response Genes;Immune system;Immunologic Memory;immunoregulation;In Vitro;in vivo;in vivo Model;Inflammasome;Inflammatory;Infrastructure;innate immune mechanisms;Innate Immune Response;Innate Immune System;Interferon Type I;Interferons;Interleukin-12;Knockout Mice;Knowledge;Leukocytes;Life;Ligands;Ligation;loss of function;Lymphocyte Subset;Lymphoid Cell;Malaria;malaria infection;Manuscripts;Mediating;Methods;Modeling;Modification;Molecular;Monitor;monocyte;Mus;Natural Immunity;novel;nucleic acid binding protein;Nucleic Acids;Organ;Paper;Parasites;Pathway interactions;Patients;Peer Review;Phagocytes;Phagolysosome;Plasmodium;Plasmodium falciparum;Plasmodium vivax;prevent;Process;Production;Productivity;programs;promoter;Publications;receptor;Regulation;Reporting;response;Role;Sampling;sensor;Signal Transduction;Site;Stimulator of Interferon Genes;Symptoms;systemic inflammatory response;T-Lymphocyte Subsets;Toll-like receptors;Toxin;Training;Untranslated RNA;Vivax Malaria;Work;World Health Organization

PROJECT_TITLE: Innate Immune Activation in Malaria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-C(02)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Notch receptors have emerged as one of the most frequently mutated genes in small B cell tumors including mantle cell lymphoma (MCL); however, progress in leveraging Notch inhibitors as therapeutic options has been stymied partly due to a limited understanding of underlying mechanisms of their sensitivity and resistance. This proposal seeks to determine precise Notch-driven regulatory circuits of key pathways that drive MCL tumor growth and identify how Notch-driven regulatory programs are altered in drug-resistant MCL. By addressing these unanswered questions, this proposal sets the stage for informed trials of Notch inhibitors in Notch-addicted MCL.

PI_NAMEs: FARYABI, ROBERT BABAK (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: 3-Dimensional;Ablation;addiction;Address;B-Cell Antigen Receptor;B-Cell Lymphomas;B-Cell Neoplasm;Binding;Biological Assay;Biopsy;Bypass;Cells;chemotherapy;Chromatin;Chromatin Loop;chromosome conformation capture;Chronic Lymphocytic Leukemia;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cytokine Signaling;Data;Disease Progression;DNA;Dominant-Negative Mutation;Drug resistance;Elements;Enhancers;Epigenetic Process;Event;Frequencies;functional genomics;FYN gene;gain of function;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genetic Enhancer Element;Genetic Transcription;Genome;genome editing;Genome engineering;Genomics;Goals;Growth;Histones;Homeostasis;Image;improved;Individual;inhibitor;Insulator Elements;Kinetics;Knowledge;Lymphoma cell;LYN gene;Malignant Neoplasms;Mantle Cell Lymphoma;Mediating;Mutate;Mutation;notch protein;Nuclear;Oncogenic;Optics;Outcome;Pathway interactions;Patients;Positioning Attribute;Prognosis;programs;Proliferating;promoter;protein expression;Proteins;receptor;Receptor Signaling;Reporting;Resistance;Resolution;Role;Sampling;secretase;Signal Pathway;Signal Transduction;SP1 gene;synergism;targeted treatment;Testing;Therapeutic;transcription factor;tumor growth;tumorigenesis;Work;Zinc Fingers

PROJECT_TITLE: Epigenetic Mechanisms Underpinning Mantle Cell Lymphoma Sensitivity and Resistance to Notch Inhibitors

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Mobilization of both adaptive and innate immune cells can assist in the treatment of breast cancer and other cancers. We have identified a protein acyl transferase enzyme, DHHC3, that may regulate both adaptive and innate anti-cancer immunity. To gain insight into the importance of DHHC3 we will i) determine whether its effects on CMTM6 palmitoylation and PD-L1 expression lead to regulation of adaptive anti-tumor immunity, and ii) determine whether its effects on oxidative stress regulators such as ERGIC3 and TXNIP are essential for regulation of oxidative stress, senescence, and tumor clearance by innate immune cells.

PI_NAMEs: HEMLER, MARTIN E (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Ablation;Adaptive Immune System;adaptive immunity;anti-cancer;Antioxidants;Breast Cancer Treatment;Cells;Enzymes;experimental study;Failure;Goals;Growth;Human;Immune;immune checkpoint blockade;In Vitro;in vivo;Innate Immune System;insight;knock-down;Lead;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Modeling;Mus;Mutate;Mutation;Natural Immunity;Natural Killer Cells;neoplastic cell;novel;novel strategies;Nude Mice;Oxidative Regulation;Oxidative Stress;Oxidative Stress Induction;palmitoylation;Physiology;Play;premature;prevent;prognostic indicator;programmed cell death ligand 1;Proteins;Regulation;restoration;Role;Sampling;Scheme;senescence;senescence associated secretory phenotype;Testing;therapeutic target;Transferase;tumor;tumor ablation;tumor growth;Tumor Immunity;tumor xenograft;TXNIP gene;Up-Regulation

PROJECT_TITLE: Targeting of tumor cell DHHC3 to enhance anti-cancer immunity

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Infants in neonatal intensive care units can sometimes experience harmful things that should not happen to them (e.g., infections). One reason this happens is because the workload of nurses gets too high, and then nurses miss important things. We will study a new way of understanding and measuring nurse workload so that in the future we can more accurately monitor nurse workload and address it when it gets too high.

PI_NAMEs: TUBBS COOLEY, HEATHER LYNN (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Absenteeism;Address;Attenuated;Behavior;Benchmarking;Care given by nurses;Caring;Code;Cognitive;Defect;Discipline of Nursing;Enrollment;Environment;Event;experience;Fatigue;Future;improved;improved outcome;Individual;Industry;Infant;Infection;innovation;Intervention;Link;longitudinal design;Measurement;Measures;Mediating;Medication Errors;Methods;Modeling;Monitor;National Institute of Child Health and Human Development;Neonatal;Neonatal Intensive Care Units;Nurses;Nursing Staff;Outcome;patient safety;Patients;peer;Performance;Physicians;pressure;Procedures;Process;Reporting;Research;Resources;Retinopathy of Prematurity;routine care;Safety;safety outcomes;Sampling;Sepsis;System;temporal measurement;Testing;Time;Travel;Variant;Work;Workload

PROJECT_TITLE: Enhancing Nursing Care Reliability in Neonatal Intensive Care Units

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The unique metabolic phenotypes found in tumors offer many promising targets for cancer therapy, but pathway redundancy has emerged as a major challenge to successfully targeting many of the most important metabolic pathways. We have found that luminal breast tumors cannot synthesize the non-essential amino acid serine due to epigenetic suppression of the gene encoding PSAT1, an enzyme in the serine synthesis pathway. In this proposal, we will determine whether this makes luminal breast tumors sensitive to inhibition of serine uptake in vivo, which may represent a new target for treatment of advanced luminal breast cancer patients.

PI_NAMEs: COLOFF, JONATHAN L. (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Acute T Cell Leukemia;Address;amino acid metabolism;Amino Acids;Anabolism;Area;asparaginase;Asparagine;auxotrophy;Biological Markers;Breast Cancer Cell;Breast Cancer Patient;cancer cell;Cancer Patient;cancer therapy;candidate identification;Cells;Circulation;Clinical;Data;Diet;dietary;Disease Resistance;Disparity;Environment;Enzymes;Epigenetic Process;epigenetic silencing;experience;experimental study;extracellular;Gene Expression;Genes;Genetic Transcription;Goals;Growth;hormone therapy;Human;In Vitro;in vivo;inhibitor;Knowledge;Malignant Breast Neoplasm;Mammary Neoplasms;Mediating;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;Methylation;Mus;Non-Essential Amino Acid;Normal tissue morphology;novel;novel therapeutics;Nutrient;Outcome;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphoserine aminotransferase;Positioning Attribute;prevent;Prognosis;Proliferating;prospective;Relapse;Research;Resistance development;Resources;Serine;side effect;Source;standard of care;Starvation;success;targeted cancer therapy;Testing;Therapeutic;therapeutic target;therapy resistant;Translating;tumor;tumor metabolism;Tumor Tissue;tumor xenograft;uptake

PROJECT_TITLE: Targeting Serine Auxotrophy in Luminal Breast Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biomedical Imaging;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Patient Safety;Pediatric;Rare Diseases

ORG_CITY: Aurora

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The traditionally subjective clinical management of patients with craniosynostosis has caused a large variability in treatment approaches between surgeons and institutions, and many patients require additional surgeries after showing unsatisfactory long-term outcomes. These suboptimal treatments are common for three main reasons: (1) local volume anomalies and their progression have not been characterized to estimate how much extra local volume patients need during treatment; (2) our knowledge about how treatment modifies cranial growth is limited and post-surgical development predictions are not possible; and (3) there are no objective and personalized methods to evaluate long-term outcomes, so treatment selection remains subjective. We aim to characterize the processes of abnormal local volume development in patients with craniosynostosis before and after treatment, create methods to evaluate, predict and compare post-surgical outcomes, and identify relapsing patients using objective data.

PI_NAMEs: PORRAS PEREZ, ANTONIO REYES  (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: 3-Dimensional;Affect;Aftercare;Age;Anatomic Surface;Anatomy;Area;bone;Bone Development;Brain;Cephalic;Child;Clinical;Clinical Management;Clinical Protocols;clinical translation;Colorado;common treatment;Compensation;Craniosynostosis;cranium;Data;Data Set;design;Development;Equation;Evaluation;Goals;Growth;Head;Image;image processing;improved;Institution;Intracranial Hypertension;Joint structure of suture of skull;Knowledge;Learning;Live Birth;malformation;Methods;model development;Modeling;multitask;neural network;novel;Operative Surgical Procedures;optimal treatments;Outcome;Pathology;Patient imaging;Patients;Pattern;Pediatric Hospitals;Phenotype;Photogrammetry;predictive modeling;Predictive Value;pressure;prevent;Process;Reconstructive Surgical Procedures;Relapse;relapse patients;Reporting;Role;Selection for Treatments;serial imaging;sex;Shapes;Software Tools;Standardization;Statistical Models;Surface;Surgeon;surgery outcome;suture fusion;Symptoms;Techniques;tool;Training;Translations;treatment optimization;Treatment outcome;treatment planning;X-Ray Computed Tomography

PROJECT_TITLE: Data-driven quantification and prediction of pre-surgical local head volume distributions and post-surgical development in patients with craniosynostosis

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project narrative. Antibiotics are wonder drugs that have tamed bacterial infections over the past century. Unfortunately, pathogens are now becoming resistant to the best antibiotics used in clinical practice today. This project is aimed at identifying non-antibiotic strategies to prevent and treat bacterial infections. Successful execution of this project will add to the arsenal of tools we have to fight bacterial infections.

PI_NAMEs: BRITTON, ROBERT A (contact);LEMON, KATHERINE PAIGE;MARESSO, ANTHONY W;PATRAS, KATY

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Active Sites;Address;antagonist;Anti-Bacterial Agents;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;antimicrobial;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Bacteriophages;beneficial microorganism;Benign;Biology;Cause of Death;Cessation of life;Chemical Structure;Chemicals;Chronic;Clinic;Clinical;clinical practice;Clinical Trials;Clostridium difficile;combat;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Communities;Complex;COVID-19 pandemic;Development;Disease;Drug resistance;drug resistant pathogen;Ecology;Effectiveness;emerging pathogen;Environment;Enzymes;Equilibrium;ESKAPE pathogens;experience;Failure;fecal transplantation;fighting;Gastrointestinal tract structure;Genes;Genetic;Genitourinary system;gut colonization;Health;high risk;high risk population;Horizontal Gene Transfer;Human;Incentives;Individual;Infection;Infection prevention;innovation;Intestines;Learning;Life;Measures;methicillin resistant Staphylococcus aureus;Methods;microbial;microbial community;microbiome;microbiome therapeutics;microbiota;microbiota composition;Modeling;Modern Medicine;mucosal site;Mucous Membrane;Mutation;Nasal Epithelium;nasal microbiota;Nature;Nose;novel;novel therapeutics;Occupations;Organoids;Outcome;pandemic disease;pathobiont;pathogen;pathogenic bacteria;pathogenic Escherichia coli;Patients;Pharmaceutical Preparations;Planet Earth;pre-clinical;pressure;prevent;Prevention strategy;Process;programs;Property;prophylactic;Public Health;Recording of previous events;repository;Research;Resistance;Resistance development;resistant strain;Resistant Streptococcus pneumoniae;Scientist;Surface;synergism;Testing;Therapeutic;tool;transmission process;Transplantation;Uncertainty;urgent and serious threat;Vaccines;Validation;viral pandemic;Virus;Work

PROJECT_TITLE: Microbiome Discovery and Mechanisms to Combat Antibiotic Resistance at Mucosal Surfaces


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases;Microbiome

PI_NAMEs: BRITTON, ROBERT A (contact)

PROJECT_TERMS: Antibiotic Resistance;Antimicrobial Resistance;Bacteriophages;college;combat;Communication;Communities;community center;Coordination and Collaboration;Data;Decision Making;design;experience;Fostering;Funding;Grant;International;Medical center;Medicine;meetings;microbiome;microbiota;Mission;Monitor;Mucous Membrane;National Institute of Allergy and Infectious Disease;outreach;Pathway interactions;Pilot Projects;programs;Reagent;Research;Research Personnel;Research Project Grants;Source;Structure;Surface;synergism;Technology;Texas;timeline;United States National Institutes of Health;Work

PROJECT_TITLE: Admin Core - Britton


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative Early detection of young people at clinical high risk for psychosis offers a critical opportunity for early intervention to improve the course of illness, and perhaps even prevent onset entirely. Current interview- based methods for psychosis risk detection lack specificity, and are only available in a handful of research centers in the United States. The proposed study aims to improve accessibility and broaden impact of high risk screening by testing brief computerized measures, ultimately able to be administered on the internet, and to improve prediction by focusing on tasks specific to underlying mechanisms driving emerging psychotic symptoms.

PI_NAMEs: CORLETT, PHILIP  (contact);WOODS, SCOTT W

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Address;American;Attenuated;Automobile Driving;Behavioral;Biological Markers;Characteristics;Clinical;clinical high risk for psychosis;clinical practice;cognitive testing;Collaborations;comparison group;computerized;Computing Methodologies;design;Detection;Diagnosis;Dimensions;disability;disorder risk;Early Diagnosis;Early Intervention;Etiology;follow-up;Foundations;Frequencies;functional decline;Functional disorder;functional outcomes;Generations;Goals;help-seeking behavior;high risk;high risk population;Human Resources;improved;Individual;Internet;Intervention Trial;Interview;Joints;Link;Longitudinal Studies;Machine Learning;machine learning classification;machine learning method;Measures;Methods;metropolitan;Modeling;neural;Neurobiology;new therapeutic target;next generation;novel strategies;online delivery;Onset of illness;Outcome;Participant;Patient Self-Report;Performance;Persons;Population;Predictive Value;prevent;preventive intervention;Primary Prevention;Process;Psychopathology;Psychoses;psychosis risk;Psychotic Disorders;psychotic symptoms;Public Health;Recording of previous events;recruit;Research;Research Personnel;Risk;Risk Assessment;Role;Sample Size;screening;Secondary Prevention;Sensitivity and Specificity;Severities;Site;social;Specificity;Symptoms;System;Techniques;Test Result;Testing;tool;Training;trait;Translating;United States;Work;Youth

PROJECT_TITLE: 5/5 CAPER: Computerized Assessment of Psychosis Risk


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Microbiome

PROJECT_TERMS: Animal Disease Models;Anti-Bacterial Agents;Antibiotic Resistance;atmospheric conditions;Bacteria;Bacterial Antibiotic Resistance;Bacteriophages;Clostridium difficile;Collection;college;combat;Communities;Complex;cost;data integration;Dedications;deep sequencing;Disease;ESKAPE pathogens;Etiology;Evolution;Faculty;Foundations;gene function;Generations;Genes;Genome;Genomics;Goals;Health;Homeostasis;Human;Human body;Human Microbiome;human model;Human Resources;Individual;Infrastructure;innovation;Intestines;Investments;Laboratories;Libraries;Lytic;Medicine;metagenome;metagenomic sequencing;Metagenomics;Microbe;microbial;microbial community;microbial genome;microbiome;microbiome alteration;microbiome research;Mission;Mucous Membrane;Nature;Nose;novel;Organoids;pathogen;pathogenic bacteria;Pathogenicity;Production;Reagent;Research;resilience;Resources;Role;Scientist;Sequence Analysis;Services;Site;Surface;Therapeutic;tool;translational study;urgent and serious threat;Vagina;Viral

PROJECT_TITLE: Microbial and Phage Cultivation Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Granulomas are the sites where M. tuberculosis and host cells interact, yet despite the importance of granulomas in TB, they are poorly understood. In this project, we employ the strengths of studies in 3 species, including humans, rhesus macaques, and new strains of mice, to understand the cell composition, spatial interactions, movements, and functional states in TB granulomas.

PI_NAMEs: ERNST, JOEL D. (contact);FENG, CARL GUANGDA

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Animal Model;Appearance;Architecture;Biology;Cell Communication;Cells;Characteristics;Chronic;Clinical;Collaborations;Data;Data Analyses;data integration;Dissociation;Environment;Failure;Flow Cytometry;Force of Gravity;Funding;Goals;Granuloma;Granuloma by Site;Human;human data;Human Pathology;human tissue;Image;Immune;Immunity;Immunologics;Immunology;improved;Infection;Infection Control;insight;Interferon Type I;Interferon Type II;Intramural Research Program;Knowledge;Label;latent infection;live cell imaging;Location;lung injury;lung repair;Lymphocyte;Macaca mulatta;Macrophage;Modification;Molecular;Mouse Strains;Movement;multidimensional data;Mus;Mycobacterium tuberculosis;Myeloid Cells;National Institute of Allergy and Infectious Disease;Nature;Necrosis;Outcome;pathogen;Pathogenesis;Pathologic;Persons;Population;Population Dynamics;Positioning Attribute;Prevention;recruit;Research Personnel;Resources;response;Role;Sampling;Signal Transduction;Site;Source;spatial relationship;Structure;success;synergism;System;Testing;therapy development;Time;Tissues;trafficking;transcriptomics;Treatment outcome;Tuberculosis;tuberculosis granuloma;tuberculosis treatment;Universities;Virulence;Wages;Work

PROJECT_TITLE: Functional dynamics of TB granuloma architecture


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Heart failure is a leading cause of death in the US and worldwide, and loss of cardiomyocytes is a major contributor to heart failure. Adult cardiomyocytes cannot replenish themselves by proliferation. The overall goals of this study is to develop comprehensive understanding of genetic pathways that dictate the inability of adult cardiomyocytes to proliferate, toward overcoming those barriers to promote cardiomyocyte renewal and preventing heart failure.

PI_NAMEs: EVANS, SYLVIA M (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Adult;Automobile Driving;Cardiac Myocytes;Cause of Death;Cell Cycle;Cell Cycle Regulation;Cell division;Code;Complex;Development;Epigenetic Process;fetal;Future;Genetic;Genetic Transcription;Goals;Heart;Heart failure;inhibitor;insight;Knowledge;Metabolic;Mitochondria;Mitotic;Morbidity - disease rate;mortality;Natural regeneration;Neonatal;Newts;Nodal;overexpression;Oxygen;Pathway interactions;prevent;Productivity;programs;Proliferating;Property;regenerative therapy;Repression;Role;Signal Pathway;Structure;success;transcription factor;Zebrafish

PROJECT_TITLE: Renewing the heart:  cardiomyocyte cell cycle regulation


PI_NAMEs: BLUTT, SARAH E (contact)

PROJECT_TERMS: Age;airway epithelium;Antibiotic Resistance;Antimicrobial Resistance;Bacteria;Bacterial Drug Resistance;Bacterial Infections;Bacteriophages;Biological;Biopsy;Bladder;Collaborations;combat;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Communication;Communities;cost;cost effective;Cost Savings;demographics;Development;Disease;Elements;Ensure;epithelial repair;Epithelium;Equipment and Supplies;Ethnic Origin;Freezing;Functional disorder;Funding;gastrointestinal;Gastrointestinal tract structure;Genomic Centers for Infectious Diseases;Goals;Growth;Growth Factor;Health;host microbiome;Human;Human Resources;Individual;Infection;Integration Host Factors;Interdisciplinary Study;interest;intestinal epithelium;Intestines;Leadership;Liver;Maintenance;Measures;meetings;member;microbial;microbiome;microbiome composition;microorganism;Modeling;Mucous Membrane;Nasal Epithelium;Nose;novel;Operative Surgical Procedures;Organoids;Outcome;pathogen;Pathogenesis;Patients;Physiological;Physiology;Play;Pre-Clinical Model;Production;Quality Control;Radiation induced damage;Reproducibility;Research;Research Personnel;Research Project Grants;response;Role;Sampling;sex;Specimen;Standardization;stem cells;success;Surface;System;Technical Expertise;Technology Transfer;Testing;Therapeutic;Time;training project;Translating;United States National Institutes of Health;Vagina;Viral;Work

PROJECT_TITLE: Organoid Cultivation Core


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_STATE: GA

PHR: PROJECT NARRATIVE Overall component Tuberculosis (TB) has been the leading infectious disease cause of death worldwide for the past decade and we are not on track to achieve the WHO End TB goal of reducing TB incidence by 90% by 2035. The mission of the Emory/Georgia TB Research Advancement Center (TRAC) is to catalyze and expand multidisciplinary research to provide new knowledge and improve our understanding of TB. The TRAC will foster the development of the next generation of TB researchers and provide resources and support for new and established TB researchers through three scientific cores – Clinical & Population Science, Basic & Translational Science, and Bioinformatics & Integrated Systems Biology.

PI_NAMEs: GANDHI, NEEL RAJNIKANT (contact);RENGARAJAN, JYOTHI

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Acceleration;Administrator;Advanced Development;Animal Model;Basic Science;biobank;Bioinformatics;Cause of Death;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communicable Diseases;Communication;Community Health;comorbidity;Country;County;Data;data sharing;Development;Diabetes Mellitus;Diagnosis;Disease;Drug Kinetics;Drug resistance;Ensure;Epidemiology;epidemiology study;Evaluation;Fostering;Foundations;Funding;Goals;Grant;Health;HIV;Human;human population study;Immune;improved;Incidence;Individual;innovation;Institution;Interdisciplinary Study;International;Investments;Knowledge;Laboratories;Leadership;Mentors;Mentorship;Mission;Morehouse School of Medicine;multidisciplinary;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;next generation;nonhuman primate;organizational structure;pandemic disease;Pathogenesis;Policies;Population Sciences;Prevention;Principal Investigator;programs;Public Health;Research;Research Personnel;Research Project Grants;Resources;response;Science;Specimen;Strategic Planning;success;Systems Biology;Technology;tool;Training;Translational Research;transmission process;Tuberculosis;tuberculosis diagnostics;tuberculosis immunity;tuberculosis treatment;Universities;Vaccines;Virulence;Vision;Work;World Health Organization


PI_NAMEs: MARESSO, ANTHONY W (contact)

PROJECT_TERMS: Acute;Address;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Bacteria;bacterial community;Bacterial Infections;Bacterial Model;Bacteriophages;Binding;Biological;Biological Availability;Biology;Biomimetics;Cells;Chronic Disease;Clinical;Clinical Treatment;clinically relevant;Collection;college;combat;Communities;Complex;Creativeness;Cytolysis;Data;Dedications;design;Development;Disease;Drug resistance;Ecosystem;efficacy testing;Elements;Environment;Epithelial Cells;Equilibrium;Etiology;Focal Infection;Foundations;Genes;genetic element;Guidelines;Health;Human;human tissue;Infection;infection risk;Inflammation;Influentials;insight;Integration Host Factors;Invaded;Knowledge;Lead;Life;Life Cycle Stages;Lytic;Maintenance;Malignant Neoplasms;Medical center;Medicine;member;microbial community;Microbiology;microbiome;microbiota;Modern Medicine;Molecular;Mucous body substance;Mucous Membrane;Multi-Drug Resistance;Nature;novel;Obesity;pathobiont;pathogen;Pathway interactions;Persons;Planet Earth;prevent;Prevention;Production;Program Description;programs;Property;Proteins;repository;Research;Resistance;Sampling;Site;solute;sugar;Surface;synergism;System;Systemic infection;Therapeutic;Therapeutic Uses;Tissue Sample;Tissues;trait;transmission process;vaccine development;Virus;Work

PROJECT_TITLE: Mechanistic insights into bacteriophage properties required for enhanced therapeutic potential at mucosal surfaces


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

PI_NAMEs: GANDHI, NEEL RAJNIKANT (contact)

PROJECT_TERMS: Area;Basic Science;Bioinformatics;career development;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Research;Clinical Sciences;Collaborations;Communication;Communities;community building;community engagement;Community Health;County;Development;Doctor of Philosophy;Ensure;Epidemiology;epidemiology study;Evaluation;Faculty;Faculty Recruitment;federal policy;Feedback;Funding;Goals;Grant;Growth;Growth and Development function;Health;Human;improved;innovation;Institution;Interdisciplinary Study;interest;International;Knowledge;Leadership;member;Mentorship;Morehouse School of Medicine;multidisciplinary;National Institute of Allergy and Infectious Disease;new growth;next generation;operation;Outcome;Policies;Policy Maker;Population Sciences;Procedures;Process;program dissemination;Public Health;Public Policy;recruit;Research;Research Personnel;Research Priority;Resource Allocation;Resources;Schools;Services;Shapes;social media;Strategic Planning;Strategic vision;success;symposium;Systems Biology;Technology;Translational Research;Tuberculosis;United States National Institutes of Health;Universities;user-friendly;Vision;web site;Work

PROJECT_TITLE: Emory/Georgia TB Research Advancement Center (TRAC)


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This project is highly significant and directly relevant to public health since it focuses on developing new methods for targeting pancreatic cancer growth and metastasis by targeting coupling between tumor microenvironment and pancreatic cancer cells. This proposal's overarching objective is to identify the critical metabolic regulators of pancreatic cancer growth in vitro and in vivo. Our paradigm shifting approach of targeting tumor microenvironment could lead to regulation of oncometabolites, provide novel understanding of pancreatic cancer growth and metastasis, and uncover critical approaches for cancer treatment.

PI_NAMEs: LAWRENCE, THEODORE S;NAGRATH, DEEPAK  (contact);NAGRATH, SUNITHA

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: addiction;Allografting;amino acid metabolism;Anabolism;Branched-Chain Amino Acids;branched-chain-amino-acid transaminase;cancer cell;cancer therapy;carcinogenesis;cell growth;Cell Line;cell transformation;Cells;Cessation of life;Citric Acid Cycle;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Complex;conditional knockout;Coupling;Cytosol;Data;Deamination;Dependence;drug development;Ecosystem;efficacy evaluation;efficacy testing;Epithelium;Event;Extracellular Matrix;Extracellular Matrix Degradation;Failure;Fibroblasts;Foundations;gabapentin;Genes;Genetic;Goals;Growth;In Vitro;in vivo;in vivo Model;inhibitor;insight;Isotopes;Keto Acids;Knockout Mice;Knowledge;Lipids;loss of function;MADH4 gene;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic;Metabolic Pathway;Methods;Mitochondria;Modeling;Nature;Neoplasm Circulating Cells;Neoplasm Metastasis;new therapeutic target;novel;Nucleotides;Nutrient;Organoids;oxidation;Oxidoreductase;Pancreas;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;Play;Production;Proteolysis;Public Health;Reaction;Recurrence;Regulation;Role;Sampling;Slice;Source;Starvation;Stromal Cells;Symbiosis;System;Testing;Time;Tissues;tool;traditional therapy;tumor;tumor metabolism;tumor microenvironment;Tumor Volume

PROJECT_TITLE: Targeting Stromal Influences on BCKA Addiction in PDAC Tumors


PI_NAMEs: KEMPKER, RUSSELL RYAN (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Area;Award;Awareness;career;career development;Career Mobility;Centers of Research Excellence;Clinical and Translational Science Awards;Clinical Sciences;Collaborations;Communication;Communities;community center;Data;Development;Diabetes Mellitus;Ensure;Epidemic;Funding;Goals;Grant;Influentials;Infrastructure;innovation;Institution;Interdisciplinary Study;Investments;Leadership;Link;Measures;Mentored Research Scientist Development Award;Mentors;Mentorship;Monitor;multidisciplinary;National Institute of Allergy and Infectious Disease;next generation;peer coaching;Process;Productivity;Program Evaluation;programs;Publications;Recording of previous events;recruit;Research;Research Infrastructure;Research Personnel;Research Support;Research Training;Resources;Science;Services;sex;skills;Specialized Center;success;tool;Training;Training Programs;Translational Research;Tuberculosis;United States National Institutes of Health;Work;World Health Organization;Writing


PI_NAMEs: SHAH, NIPPIE SARITA (contact)

PROJECT_TERMS: Acceleration;Affect;Basic Science;biobank;Biological Specimen Banks;Biometry;Biostatistical Methods;Centers for Disease Control and Prevention (U.S.);Childhood;Clinical;clinical care;Clinical Data;Clinical Research;clinical research site;Clinical Sciences;cohort;Collaborations;Communities;Conceptions;Consultations;Country;County;Data;Data Analyses;data management;Data Management Resources;data repository;Data Set;Databases;design;Diabetes Mellitus;Discipline;Doctor of Philosophy;Drug resistance in tuberculosis;Enrollment;Ensure;Environment;Epidemic;epidemiologic data;Epidemiologic Methods;epidemiology study;Ethiopia;experience;Faculty;field study;Fostering;Goals;Health;HIV/TB;improved;Infection Control;Infectious Diseases Research;innovation;Institution;instrument;Interdisciplinary Study;International;Kenya;Laboratories;Leadership;Libraries;Link;lung health;marginalized community;Methods;Modeling;Molecular Epidemiology;multidisciplinary;Mycobacterium tuberculosis;next generation;open data;Output;Pathway Analysis;patient population;Philippines;Policies;Policy Making;Population Sciences;Positioning Attribute;Productivity;programs;protocol development;Pulmonary Tuberculosis;Records;recruit;repository;Research;Research Design;Research Personnel;research study;Resources;sample collection;Science;Scientist;secondary analysis;Site;South Africa;Specimen;Statistical Methods;study population;Training;Translating;Translational Research;transmission process;Uganda;Universities;user-friendly;vulnerable community;Work


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Depression;Emerging Infectious Diseases;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

PHR: Project Narrative This project builds on a 14-year follow-up, scheduled for 2022, of a cohort of children and adolescents living in agricultural communities in Ecuador (the ESPINA Study). This project proposes to assess whether pesticide spray seasons are associated with cyclical alterations in mental health symptoms and cognitive performance assessed over two years using a smartphone-based assessment platform, and to test whether pesticide exposure biomarkers are related to elevated depressive and externalizing symptoms and decreased cognitive performance. Findings from this project will advance the current field of environmental health and inform future brain and mental health risk assessments.

PI_NAMEs: MOORE, RAEANNE CRISTINE;SUAREZ, JOSE RICARDO (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 2019-nCoV;Acetylcholinesterase;Acetylcholinesterase Inhibitors;Adolescence;Adolescent;Adolescent and Young Adult;Affect;Age;aged;Aggressive behavior;agricultural community;agricultural pesticide;Agriculture;Agrochemicals;Americas;Anxiety;Assessment tool;Attention;Biological Markers;Blood;Brain;brain health;California;Carbamates;Cellular Phone;Child;cholinergic;Cognition;Cognitive;cognitive change;cognitive performance;cognitive testing;cohort;community based participatory research;Complex;County;COVID-19;COVID-19 sequelae;depressive symptoms;design;Development Plans;disability;Disease;Economics;Ecuador;Ecuadorian;Environment;Environmental Exposure;Environmental Health;Environmental Pollutants;Epidemiology;Exposure to;externalizing behavior;Flowers;follow-up;Funding;Future;girls;Health;health assessment;Health Technology;human data;Immunoglobulin G;improved;Impulsivity;individual variation;Industry;Insecticides;Knowledge;Link;Measures;Memory;Mental Depression;Mental disorders;Mental Health;mHealth;mood regulation;Moods;Natural experiment;neurobehavior;neurobehavioral;Neurocognitive;Neurodevelopmental Disability;neurotoxic;novel;Nutritional;Organophosphates;Outcome;Participant;Performance;Persons;pesticide exposure;Pesticides;Population;Process;processing speed;prospective;Prospective, cohort study;Psyche structure;psychosocial;psychosocial stressors;Public Health;pyrethroid;Reaction Time;Recurrence;Research;Risk Assessment;Sampling;Schedule;Seasons;sex;Short-Term Memory;smartphone based assessment;Standardization;stressor;Substance abuse problem;Surveys;Symptoms;System;Testing;toxic organophosphate insecticide exposure;Toxicology;United States National Institutes of Health;Universities;urinary;Work;young adult;Youth

PROJECT_TITLE: Cyclical Alterations In Neurocognitive Performance And Mood Over Two Years In Relation To Pesticide Spray Seasons Among Adolescent And Young Adult Participants Of The Espina Study.

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Rare Diseases;Tuberculosis;Vaccine Related

PI_NAMEs: DAY, CHERYL LIANE (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Animal Model;Animals;Archives;Area;assay development;Award;Basic Science;biobank;Biological;Biological Assay;Cell Culture Techniques;Cells;Cessation of life;Clinical;co-infection;cohort;Collaborations;college;combat;community center;Consultations;Control Animal;Data;Data Analyses;Databases;Development;Disease;Doctor of Philosophy;Electronics;Environment;Experimental Designs;Extramural Activities;Faculty;Flow Cytometry;Foundations;Funding;Goals;Health;high dimensionality;HIV;HIV/TB;Human;human model;Immunity;Immunologics;Immunology;In Vitro;Infection;innovation;Institution;instrument;Knowledge;Laboratories;laboratory equipment;Lead;Leadership;Link;member;Methods;Microbiology;Mission;Modeling;multidisciplinary;mycobacterial;Mycobacterium Infections;Mycobacterium tuberculosis;nonhuman primate;novel strategies;pandemic disease;Pathogenesis;Primates;programs;protocol development;repository;Research;Research Personnel;Resources;Rodent;Series;Services;SIV;Sorting;Specimen;Surveys;Talents;tool;Training;Translational Research;transmission process;Tuberculosis;tuberculosis immunity;Universities;Vaccination;vaccine trial;Vaccines;Veterinary Medicine


NIH_SPENDING_CATS: Cancer;Chronic Pain;Neurosciences;Pain Research;Prostate Cancer;Urologic Diseases

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The goal of this proposal is to reveal 1) how cancer cells induce painful complications of bone metastases, and 2) the mechanisms whereby pain signals promote the growth of bone metastatic cancer cells. We will also block this cancer-nerve interaction to treat bone metastases and its painful complication. This study will provide insights into the roles of sensory nerves in bone metastatic progression, and safer and more effective treatment strategies for bone metastases and associated pain.

PI_NAMEs: SHIOZAWA, YUSUKE  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Address;Affect;afferent nerve;Afferent Neurons;Animals;Area;Attenuated;Benign;Biopsy;bone;Bone Development;Bone Diseases;Bone Growth;Bone Pain;Bone remodeling;Calcitonin Gene-Related Peptide;calcitonin receptor-like receptor;Calcitonin-Gene Related Peptide Receptor;cancer cell;Cancer Control;Cancer Model;Cancer Patient;cancer survival;carcinogenesis;Cause of Death;Cells;Complication;Data;Disease Progression;effective therapy;FLT3 gene;ganglion cell;Goals;Growth;Harvest;Immune;Impairment;improved;In Vitro;in vivo;insight;Ligands;Malignant Bone Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Marrow;Measures;Mediating;Metastasis Induction;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Molecular Probes;mortality;mouse model;Mus;Neoplasm Metastasis;Nerve;nerve supply;Neuropeptides;new therapeutic target;novel therapeutic intervention;p38 Mitogen Activated Protein Kinase;Pain;pain behavior;pain signal;palliative;Pathway interactions;Patients;Peptide Synthesis;Peptides;Periosteum;Plasma;Primary Neoplasm;Prognosis;Proliferating;prostate cancer cell;prostate cancer model;prostate cancer progression;Quality of life;Radium;receptor;response;Role;Scheme;skeletal;soft tissue;Spinal Ganglia;Symptoms;System;targeted cancer therapy;Tissues;treatment strategy;tumor;tumor growth;tumor progression;Work

PROJECT_TITLE: The contributions of sensory nerves to bone metastasis and associated bone pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-H(55)R]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_DEPT: GENETICS

PHR: NARRATIVE This proposal aims to understand how different cell types in the developing embryo are generated, the transcription factors involved and the sequences in the genome activated in different cells. Our findings will inform human development and lay the foundation to investigate human developmental disorders.

PI_NAMEs: GIRALDEZ, ANTONIO J (contact);KRISHNASWAMY, SMITA

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Address;Affect;Architecture;Binding;Cell Differentiation process;cell fate specification;Cell Lineage;Cell Reprogramming;cell type;Cells;Chromatin;Code;Collaborations;combinatorial;Complex;computer framework;Computing Methodologies;Data;Data Set;Development;developmental disease;Disease;DNA;Embryo;Embryonic Development;Engineering;Epigenetic Process;Etiology;Evolution;Fertilization;Foundations;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;Genetic;Genetic Transcription;Genome;Genomics;Goals;Human;Human Development;human embryonic development;In Vitro;in vivo;Individual;Learning;Logic;loss of function;Maps;Mathematics;Mediating;Molecular;mutant;Mutate;novel;Outcome;posttranscriptional;predictive modeling;programs;recruit;Regenerative Medicine;Repression;segregation;Shapes;Signal Transduction;single cell ATAC-seq;single cell genomics;single cell sequencing;single-cell RNA sequencing;Specific qualifier value;System;Testing;Time;Totipotent;transcription factor;vertebrate embryos;Vertebrates;Work

PROJECT_TITLE: Deciphering the regulatory code that specifies different cell fates in development using single cell genomics

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Data Science;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Networking and Information Technology R&D (NITRD);Rare Diseases;Tuberculosis

PI_NAMEs: COLLINS, JEFFREY M (contact)

PROJECT_TERMS: Address;Area;ATAC-seq;Basic Science;Bioinformatics;Biological Assay;Biological Markers;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;ChIP-seq;Clinical;Clinical Sciences;Color;Communicable Diseases;Communities;Complex;Computational Biology;computational pipelines;Computer Models;Consultations;Core Facility;cytokine;Data;data acquisition;Data Analyses;data integration;Data Set;Development;Diagnosis;Dimensions;Disease;Disease Progression;Doctor of Philosophy;Education;education resources;Educational workshop;Environment;epigenomics;Experimental Designs;experimental study;Faculty;Flow Cytometry;Fostering;Functional disorder;Funding;Genes;Genomics;graduate student;high dimensionality;Immune Evasion;Immunity;Immunology;Immunology procedure;Individual;Infrastructure;innovation;Institution;Intake;Interdisciplinary Study;Investigation;Knowledge;Laboratories;Lead;Leadership;lipidome;lipidomics;Measurement;member;Mentorship;Metabolic Pathway;metabolic phenotype;metabolome;metabolomics;Methods;microbiome analysis;Modeling;multidimensional data;Multiomic Data;multiple omics;multiscale data;next generation;novel;Pathway Analysis;Postdoctoral Fellow;Prevention;Records;Research;Research Design;Research Personnel;Resolution;Resource Sharing;Resources;Services;single cell technology;single-cell RNA sequencing;Structure;System;Systems Biology;Systems Integration;Technology;Tissues;tool;Training;Training and Education;transcriptome sequencing;transcriptomics;Translational Research;Tuberculosis;United States National Institutes of Health;uptake;World Health Organization


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Complementary and Integrative Health;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition;Prevention;Urologic Diseases

PROJECT_TERMS: Accounting;Acute;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Back;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Bacteriophages;carbapenem resistance;Cause of Death;Cessation of life;Clinical Trials;clinically relevant;Clostridium difficile;colonization resistance;combat;commensal bacteria;commensal microbes;Communicable Diseases;Communities;design;Diagnosis;Diet;Disease;Drug resistance;dysbiosis;Enterobacteriaceae;environmental change;Escherichia coli;Escherichia coli Infections;experimental study;Exposure to;Extended-spectrum β-lactamase;fecal transplantation;Focal Infection;gastrointestinal;Goals;Growth;gut microbiome;gut microbiota;Health Benefit;healthcare-associated infections;Hospitals;Human;Human body;Human Microbiome;human microbiota;human tissue;In Vitro;Individual;Infection;Infection prevention;Inflammation;innovation;Intervention;Intestines;Learning;Lytic;Medical Care Costs;Metabolic;metabolomics;Methods;Microbe;microbial;microbial community;Microbial Physiology;microbiome;microbiota;mouse model;Mucous Membrane;multi-drug resistant pathogen;novel;Nutritional;opportunistic pathogen;Organoids;Outpatients;pathobiont;pathogen;Pathogenesis;pathogenic bacteria;pathogenic Escherichia coli;Patients;Persons;Pharmaceutical Preparations;Pneumonia;Population Heterogeneity;Predisposition;preservation;pressure;prevent;Prevention strategy;Probiotics;Property;Public Health;Recurrence;recurrent infection;Resistance;Risk;Sampling;Site;stool sample;success;Surface;synergism;Testing;Therapeutic;tissue culture;transmission process;United States;Urinary tract infection;Uropathogen;Vagina;Virulence;Work

PROJECT_TITLE: Defined microbial communities to prevent and eradicate infection by AMR pathogens


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Infectious Diseases;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The thirteen known genetic etiologies of ‘isolated’ (AR IL-17RA, IL-17RC, ACT1, and AD IL-17F deficiencies) or ‘syndromic’ CMC (AR CARD9, IL-12p40, IL-12Rb1, ROR-g/gT, ZNF341, and AD JNK1, IL6ST, STAT3 deficiencies, and AD STAT1 GOF) impair IL-17A/F immunity. The molecular and cellular mechanisms that disrupt IL-17 immunity and underlie CMC remain incompletely understood, while half of the patients with idiopathic CMC lack a genetic etiology. We thus aim to pursue the molecular, cellular, immunological, and clinical study of both known and novel inborn errors of IL-17A/F immunity in patients with isolated or syndromic CMC.

PI_NAMEs: CASANOVA, JEAN-LAURENT  (contact);PUEL, ANNE

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Affect;Autoantibodies;Autoimmune;Autoimmunity;autosome;Biological;Candida albicans;CD4 Positive T Lymphocytes;Cell Count;Cells;Chronic Mucocutaneous Candidiasis;Clinical;clinical phenotype;Clinical Research;Communicable Diseases;congenital immunodeficiency;cytokine;Development;differentiation in vitro;dimer;Dissection;Dominant-Negative Mutation;Dryness;Etiology;exome;Family;fungus;gain of function;gain of function mutation;Genes;Genetic;Genetic Counseling;Genetic Predisposition to Disease;Genetic study;Genitalia;genome sequencing;genome-wide;genome-wide linkage;Hereditary Disease;Heterozygote;Human;Human Genetics;Hyper-IgE Syndrome;IL17 gene;IL6ST gene;Immunity;Immunologics;Impairment;Individual;Infection;Infectious Agent;Infectious Disease Immunology;Inherited;inhibitor;innovation;insight;Interferon alpha;Interferon Type II;interleukin-17E;interleukin-21;interleukin-21 receptor;interleukin-23;Interleukin-6;International;Job's Syndrome;kindred;Laboratories;Leadership;Lesion;Leukocytes;loss of function mutation;Loss of Heterozygosity;Lymphocyte;MAPK8 gene;Mediating;Memory;Molecular;Molecular Diagnosis;Molecular Genetics;Mucous Membrane;Mutation;Nail plate;novel;Nuclear;Oral;Pathogenesis;Patients;Penetrance;Phenotype;Phosphoric Monoester Hydrolases;Physicians;Polyglandular Autoimmune Syndrome Type I;precision medicine;prevent;Production;Protein Dephosphorylation;Protein Tyrosine Phosphatase;PTPN1 gene;recruit;Recurrence;recurrent infection;Reporting;Research;Resistance;response;Role;Scalp structure;Signal Transduction;Skin;Staphylococcal Skin Infections;STAT1 gene;STAT3 gene;T cell response;T-cell protein tyrosine phosphatase;T-Lymphocyte;Testing;trait;Variant;whole genome;Work

PROJECT_TITLE: Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative Malaria caused by infection with Plasmodium vivax results in significant morbidity around the world, and resistance to antimalarial treatments presents a major hurdle to control and elimination efforts. Here, we will use a combination of evolutionary and experimental genetic methods to identify putative P. vivax molecules involved in drug resistance. Following confirmation, P. vivax drug resistance polymorphisms will be key to surveillance for antimalarial efficacy and the design of strategies to prolong the usefulness of antimalarial drugs.

PI_NAMEs: DURAISINGH, MANOJ T (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Anti-malarial drug resistance;Anti-malarials;Artemisinins;Biological Assay;Case Management;Chloroquine;Chloroquine resistance;Clinical;Comparative Genomic Analysis;Country;design;Development;drug candidate;Drug resistance;epidemiology study;Experimental Genetics;Exposure to;fitness;forward genetics;Genes;Genetic;Genetic Polymorphism;Genetic Screening;genomic data;Genomics;In Vitro;Individual;Infection;Libraries;Macaca;Malaria;Mediating;member;Methods;Molecular;Molecular Analysis;Molecular Epidemiology;Morbidity - disease rate;novel;novel strategies;Orthologous Gene;overexpression;Parasite resistance;Parasites;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Phylogenetic Analysis;Plasmodium falciparum;Plasmodium knowlesi;Plasmodium vivax;Policies;Population;Predictive Value;Predisposition;premature;Primaquine;programs;Public Health;Recording of previous events;regional difference;Reporting;Resistance;resistance allele;resistance gene;resistance mechanism;reverse genetics;Risk Factors;Role;Scanning;Southeastern Asia;Transfection;Treatment outcome;Validation;Variant;Vivax Malaria;Work;Zoonoses

PROJECT_TITLE: Molecular basis of antimalarial drug resistance in Plasmodium vivax

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-Q(83)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE CD97 is an adhesion class G-protein coupled receptor (aGPCR) frequently expressed in human acute myeloid leukemia (AML) that is required for LSC self-renewal. CD97 exists as three isoforms with potential differences in ligand binding and signaling profiles; however, it is not clear if there are isoform-specific roles for CD97 in LSCs. We will use a combination of genetic and molecular approaches, including novel human synthetic CD97 antibodies we have generated, to identify the physiologically relevant interaction domains as well as the structural and signaling requirements for CD97 function; these studies will not only yield novel insights into the mechanisms that regulate LSC self-renewal, but identify specific antibody reagents that may be quickly translated to the clinic.

PI_NAMEs: PARK, CHRISTOPHER Y (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adhesions;Adult Acute Myeloblastic Leukemia;Affinity;Aftercare;Alternative Splicing;Antibodies;antibody engineering;Antibody Therapy;Antigens;antileukemic activity;Binding;Biological Assay;Biology;CD97 gene;Cells;Cessation of life;chemotherapy;Clinic;Clinical;Coupled;curative treatments;Data;design;Disease;EGF-Like Domain;Engineering;Epitopes;Exhibits;experimental study;extracellular;Extracellular Domain;G-Protein-Coupled Receptors;Genetic;Goals;Growth;Hematopoietic;Hematopoietic stem cells;Human;In Vitro;in vivo;in vivo Model;insight;leukemia;leukemic stem cell;leukemic transformation;leukemogenesis;Ligand Binding;Ligand Binding Domain;Ligands;Maintenance;Malignant Neoplasms;Mammalian Cell;Mediating;member;migration;Molecular;Molecular Probes;mouse model;mRNA Expression;Mus;N-terminal;novel;Outcome;Pathogenesis;Phenotype;phosphoproteomics;Physiological;Play;Population;Positioning Attribute;Pre-Clinical Model;prognostic;Property;Protein Engineering;Protein Isoforms;Publishing;Reagent;receptor structure function;Regulation;Relapse;Research Personnel;Resistance;Role;screening;self-renewal;Signal Induction;Signal Transduction;Solid;Specificity;stem cell biology;stem cell function;stem cell growth;stem cell self renewal;synthetic antibodies;synthetic protein;targeted treatment;Testing;Therapeutic;therapeutic target;therapy development;therapy resistant;tool;Toxic effect;transcriptome sequencing;transcriptomics;Translating;Translations;Transplantation;Undifferentiated;Variant;Xenograft Model

PROJECT_TITLE: Adhesion GPCR regulation of acute myeloid leukemia stem cells - Resubmission - 1

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Prevention

PI_NAMEs: LEMON, KATHERINE PAIGE (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Adult;Affect;Air;Antibiotic Resistance;Apoptotic;attenuation;Bacteria;Bacterial Antibiotic Resistance;Bacteriophages;Benign;Biological Assay;Cell Culture Techniques;Cessation of life;Child;Clinical Trials;Coculture Techniques;Collection;colonization resistance;Colony-forming units;combat;Combating Antibiotic Resistant Bacteria;Communities;Corynebacterium;cytokine;Data;Epithelium;experience;fluorescein isothiocyanate dextran;Genome;Growth;Human;Immune response;improved;In Vitro;Infection;Infection prevention;innovation;Invaded;Knowledge;Liquid substance;Lytic;metabolomics;Methods;microbial;microbiome;microbiota;microbiota composition;Microscopy;Molecular;Mucous Membrane;Nasal Epithelium;nasal microbiome;nasal microbiota;nasal swab;Nose;Organoids;Outcome;pathobiont;Permeability;Persons;Physiology;Population;pre-clinical;Predisposition;prevent;Production;repaired;Reporting;Reproducibility;Resistance;response;Risk;Sampling;Serotyping;Shapes;Source;Staphylococcus aureus;Streptococcus pneumoniae;Surface;System;Testing;Therapeutic;Tight Junctions;tissue derived stem cell;Topical Antibiotic;transcriptomics;transmission process;Vaccines;Validation;Virulence

PROJECT_TITLE: Nasal Microbial Consortia Combat Antibiotic-Resistant Bacteria


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Hematology;Immunotherapy;Pediatric;Pediatric Cancer;Rare Diseases;Transplantation

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Natural killer (NK) cell therapy for acute leukemia and multiple myeloma is limited by lack of NK cell persistence and loss of function. A subset of NK cells, called adaptive NK cells, is longer-lived and exhibit enhanced functional responses against tumor cells. This proposal will investigate the use of adaptive NK cells to treat leukemia and myeloma and test methods to retain their function after exposure to tumor cells.

PI_NAMEs: MERINO, AIMEE  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;Adaptive Behaviors;Adoptive Transfer;Advisory Committees;Allogenic;Antigens;Antitumor Response;Autologous Transplantation;Blood Cells;Blood specimen;blood treatment;Bone Marrow;Bone Marrow Transplantation;cancer cell;Cancer Center;cancer therapy;career;Cell Density;cell killing;Cell Physiology;Cell Survival;Cell Therapy;Cells;Cellular biology;checkpoint receptors;Chronic;Clinical;clinical application;Clinical Trials;Collecting Cell;cytokine;Cytomegalovirus;Cytomegalovirus Infections;Cytoplasmic Granules;Data;efficacy testing;Engraftment;Enrollment;Environment;exhaust;exhaustion;Exhibits;experience;Exposure to;Fellowship;follow-up;Follow-Up Studies;functional restoration;Funding;Future;Goals;Hematopoietic Neoplasms;Human;Immune;immune checkpoint blockade;Immunologic Memory;improved;In complete remission;In Vitro;in vitro Assay;in vivo;Inflammatory;Infusion procedures;instructor;knowledge base;Leadership;leukemia;leukemia relapse;leukemia treatment;life span;Longevity;loss of function;Lymphocyte;Lytic;Malignant - descriptor;Malignant Neoplasms;Mediating;Mentorship;Methods;Minnesota;mouse model;Multiple Myeloma;Mus;Natural Killer Cells;neoplastic cell;NK cell therapy;novel;novel strategies;Patients;peripheral blood;Phase I/II Clinical Trial;Phase I/II Trial;phenotypic biomarker;Postdoctoral Fellow;Predisposition;primary outcome;prospective;receptor;receptor expression;Records;recruit;Refractory;Relapse;Reporting;Research;Research Personnel;Resistance;response;Safety;Sampling;Scientist;seropositive;skills;Specificity;Stem cell transplant;success;Technical Expertise;Testing;Time;trafficking;Training;Transfection;Transfusion;Translating;translational cancer research;Transplantation;tumor microenvironment;Universities;Viral;Work

PROJECT_TITLE: Understanding and improving responses to adaptive NK cell therapy for leukemia and multiple myeloma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

PHR: NARRATIVE: My lab’s work has been at the forefront of studies showing that nuclear organization and long-range chromatin interactions play an essential role in gene regulation and its impact on health and disease. To extend our studies we aim to explore two poorly understood, interlinked biological problems: Project 1: Understanding bookmarking in the context of mitotic chromatin folding; Project 2: Mechanisms underlying the chromatin organization and gene regulation of quiescent cells.

PI_NAMEs: SKOK, JANE AMANDA (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Affinity;Binding;Biological;Biological Process;Cell Cycle;Cells;Chemicals;Chromatin;Chromatin Loop;Chromosome Structures;Chromosomes;cohesin;computational pipelines;condensin;daughter cell;Developmental Process;Disease;DNA;epigenetic memory;Epigenetic Process;Fishes;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Recombination;Genetic Transcription;Genome;Goals;Growth Factor;Health;Image;Individual;Link;Mediating;Methodology;Mitosis;Mitotic;Modernization;Molecular;Nuclear;Nutrient;Phenotype;Play;Population;Positioning Attribute;preservation;Process;programs;promoter;Regulatory Element;Repression;response;RNA;Role;Signal Transduction;Site;Stress;Structure;Toxic effect;Work

PROJECT_TITLE: Nuclear organization and its role in gene regulation

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Wound Healing and Care

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: 8. Project Narrative Scarring is the end result of injury in adult skin and results in an enormous financial and medical burden for our society, yet no molecular therapies exist that can prevent scarring or its sequelae. Facial wounds heal with reduced scars compared to back and abdominal scars; however, molecular drivers governing the outcome of skin wounds derived from different embryonic origins remains unknown. Therefore, we will explore the biomolecular and tissue mechanical drivers of facial skin healing in order to facilitate development of novel targets to minimize scarring and promote regenerative wound healing.

PI_NAMEs: LONGAKER, MICHAEL T (contact);WAN, DERRICK

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Abdomen;Accounting;Adult;Back;Bromodomain;Bromodomains and extra-terminal domain inhibitor;Cell Differentiation process;Cell Transplantation;cell type;Cells;Cessation of life;Characteristics;Cicatrix;Clinical;Computational algorithm;CRISPR/Cas technology;Cutaneous;Data;Deposition;Development;Differentiation Inhibitor;Dorsal;Embryo;EP300 gene;Evaluation;Extracellular Matrix;Extracellular Matrix Proteins;F-Box Proteins;Face;face skin;Fiber;Fibroblasts;Fibrosis;Flow Cytometry;functional loss;Genetic Transcription;Growth;Harvest;healing;Heterogeneity;Histologic;Histology;Histone Acetylation;histone acetyltransferase;Immunohistochemistry;inhibitor;Injury;Knock-out;Lateral;Light;machine learning algorithm;Measures;Mechanics;Medical;Mesoderm;Molecular;Morbidity - disease rate;mortality;Mus;Natural regeneration;Neural Crest;new therapeutic target;novel;Organ;Outcome;overexpression;Pathway interactions;Pattern;Phenotype;prevent;Process;protein protein interaction;Proteins;Proteomics;psychosocial outcome;regenerative;Regenerative capacity;regenerative healing;Regenerative wound healing;Role;Scalp structure;Signal Transduction;single-cell RNA sequencing;Site;Skin;skin fibrosis;skin healing;Skin injury;skin wound;Skin wound healing;small molecule;small molecule inhibitor;Societies;Somites;Surgical Models;Therapeutic;therapeutic target;therapy development;Tissues;tool;transcriptomics;Transgenic Organisms;translational goal;transplant model;Transplantation;treatment strategy;United States;Work;wound;wound healing;wound treatment

PROJECT_TITLE: Reprogramming fibroblasts embryonic origins to overcome skin fibrosis and scarring.

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Nutrition

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Metabolic function can cause cellular stress, which in term can impact aging. We found that an understudied stress response in the Golgi regulated lipid metabolism and is important for a compensatory pathway that affects secretory function and changes during aging. By understanding how this link between metabolism and stress is regulated, we will make important insights into mechanisms underlying changes in the aging process. These processes are also relevant to a broad variety of human diseases such as Alzheimer’s and Parkinson’s disease.

PI_NAMEs: WALKER, AMY KAROL (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Affect;Age;Aging;aging process;aging related;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Animal Model;Animals;arm;Binding;Biochemical;Biochemistry;biological adaptation to stress;Biological Assay;Caenorhabditis elegans;Calories;Carbon;Cell Aging;Cell Line;Cell Physiology;Cells;Cellular biology;Cellular Stress;Compensation;Data;Egg Yolk Proteins;Endoplasmic Reticulum;Environment;Enzymes;Epigenetic Process;Esthesia;experimental study;extend lifespan;Genetic;Genetic Screening;Genetic Transcription;Golgi Apparatus;Guanosine Triphosphate Phosphohydrolases;Health;HMGB1 gene;Homeostasis;Human;human disease;In Vitro;in vivo;Individual;insight;Intestines;Investigation;Lecithin;life span;Link;Lipid Bilayers;lipid metabolism;Lipids;Lipodystrophy;Mammalian Cell;Measures;Membrane;Metabolic;Metabolic Diseases;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Mitochondria;Modeling;Modification;Molecular;mutant;Mutation;N-terminal;Nature;Neurodegenerative Disorders;Nutrient;Nutritional;Organelles;Orthologous Gene;Output;paralogous gene;Parkinson Disease;Pathway interactions;Patients;Peptide Hydrolases;Phenotype;Phospholipids;Play;Process;Production;programs;Property;Proteins;rate of aging;Regulation;repaired;response;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Signal Transduction;Site;Source;SRE-1 binding protein;Stress;Tissues;transcription factor

PROJECT_TITLE: Dual transcriptional programs coordinate lipogenic and membrane stress responsive programs in C. elegans

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: England

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF LEEDS

ORG_ZIPCODE: ls2 9jt

PHR: Project Narrative: The financial and humanitarian cost associated with enteroviruses is substantial - this project aims to understand key aspects of the lifecycle that can be then targeted therapeutically. We are focussing on the protein shell, termed a capsid, this surrounds the viral genetic material and is made up of repeating copies of three proteins. After assembling around the genome, one of these proteins is cleaved by an unknown mechanism into two, which converts the particle into an infectious form, the resolution of this process may pave the way to developing antiviral drugs and vaccines.

PI_NAMEs: STONEHOUSE, NICOLA J (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Anti-viral Agents;Anti-viral Therapy;antiviral drug development;Biochemical;Bioinformatics;Biological Assay;Capsid;Catalytic Domain;Chemical Structure;Chemicals;Classification;Clinical;co-infection;cost;Cryoelectron Microscopy;Data;design;Development;Disease;Echo Viruses;Encephalitis;Ensure;Enterovirus;Enterovirus Infections;Enzyme-Linked Immunosorbent Assay;Event;Family;Foundations;Future;Generations;Genetic Materials;Genetic Recombination;Genetic Transcription;Genome;Hand, Foot and Mouth Disease;Hospitalization;Human poliovirus;In Vitro;Infection;inhibitor;Life Cycle Stages;Measures;Mediating;Modeling;Molecular;Molecular Conformation;mutant;Mutation;Myelitis;novel;novel vaccines;Outcome;pan-enterovirus;particle;Pathway interactions;Phenotype;Polyproteins;Process;Proteins;Protocols documentation;Protomer;prototype;Publishing;reconstruction;Resolution;RNA;Role;Sampling;Sedimentation process;Series;small molecule inhibitor;Structural Models;Structure;Study models;success;targeted treatment;Techniques;Testing;therapeutic target;Translating;vaccine development;Vaccines;Viral;Viral Genome;Viral Proteins;Virion;Virus;Virus Assembly;virus genetics;Virus Replication;Western Blotting;Work

PROJECT_TITLE: Understanding the fundamental enterovirus capsid assembly and maturation pathway.


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

PHR: PROJECT NARRATIVE My goal for the K25 award is to establish myself as an independent neuroimaging statistician, with expertise in whole-brain network analyses and an integral member of multidisciplinary research teams devoted to addressing diseases of the brain. The training component of this award will provide a foundation in image analysis and computational neuroscience to deepen my understanding of the brain as a complex system. The research activities will focus on developing new methodology to improve whole-brain dynamic connectivity analyses with the end goal of improving patient outcomes for various brain disorders.

PI_NAMEs: SHAPPELL, HEATHER MARIE (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Accounting;Address;Alzheimer's Disease;Award;Behavior;Biology;biomarker identification;Brain;Brain Diseases;brain dysfunction;Brain region;Brain scan;career;Clinical;Cognition;Communication;Complex;computational neuroscience;Computer software;Data;Data Analyses;Data Collection;Dedications;Detection;detection limit;Diagnosis;early detection biomarkers;Education;Educational workshop;Environment;Exhibits;experimental study;Foundations;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;Growth;Head;Human;Image;Image Analysis;improved;Individual;infancy;innovation;insight;Interdisciplinary Study;interest;Journals;Knowledge;Lead;markov model;Medicine;member;Mentors;Methodology;Methods;Modeling;Morphologic artifacts;Motion;neuroimaging;Neurologic;Neurosciences;novel;Participant;Pathway Analysis;Patient-Focused Outcomes;Predisposition;Prevention;Research;Research Activity;Research Design;Research Project Grants;response;Scanning;Scientist;Series;skills;Slide;Statistical Data Interpretation;Statistical Methods;Structure;study population;symposium;System;Techniques;theories;Time;tool;Training;Training Activity;Training Programs;Variant;Vocational Guidance;Work

PROJECT_TITLE: Statistical Methods for Whole-Brain Dynamic Connectivity Analysis


PHR: PROJECT NARRATIVE Harnessing epigenetic regulation into Synthetic Biology has the potential of augmenting the scope of cellular engineering with the functional capabilities of that support natural development, such as integration of multiple signals over time to support cellular fate decisions that are stably inherited and the execution of temporally controlled gene expression programs. To address this need, the proposed research aims will establish a versatile circuit design platform that leverages epigenetic regulation to elicit memory and temporally regulated expression programming in mammalian cells, such as cellular timers to orchestrate gene expression sequences, recorders for monitoring and appropriately responding to disease in the host and artificial cell differentiation to drive cells to adopt distinct and complementary functional roles. These capabilities will be critical for engineering novel cell therapies to effectively tackle complex diseases and address future therapeutic challenges.

PI_NAMEs: BARBOSA DE ALMEIDA, RICARDO AUGUSTO ;LIM, WENDELL A (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;Adopted;Antigens;Area;cell behavior;Cell Differentiation process;cell killing;Cell Line;Cell Therapy;Cells;cellular engineering;chimeric antigen receptor T cells;Chromatin;Chronic;combinatorial;Complex;Cues;design;Development;Disease;Engineering;epigenetic memory;Epigenetic Process;epigenetic regulation;exhaustion;Exposure to;extracellular;Future;Gene Expression;genetic information;Immunotherapy;in vivo;Inherited;Kinetics;Mammalian Cell;Memory;Monitor;notch protein;novel;Population;programs;Property;receptor;recombinase;regenerative cell;Regenerative Medicine;Research;response;Role;sensory input;Signal Transduction;Specific qualifier value;Stimulus;Support System;synthetic biology;Synthetic Genes;System;T-Lymphocyte;Therapeutic;Time;treatment response;tumor;Variant;Work

PROJECT_TITLE: Synthetic epigenetic circuits: tunable cell fate switches controlled by dynamic and combinatorial inputs

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Biomedical Imaging;Congenital Structural Anomalies;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Regenerative Medicine;Spina Bifida

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because it is expected to enhance long-term neurological and neurodevelopmental outcomes following in-utero spina bifida repair through use of innovative strategies, thereby representing a major national cost as measured by both patient and their caregivers’ quality of life and economic burden. Though combination of surgical technique and a regenerative biomaterial with beneficial properties, these studies will provide fundamental insights into how spinal cord deterioration can be mitigated, leading to a foundation for the development of new strategies for treating spina bifida in-utero. Thus, this proposal is relevant to the part of the NIH’s missions and goals pertaining to enhancing health and reducing illness and disability, and to foster innovative research strategies and their applications as a basis for ultimately protecting and improving health.

PI_NAMEs: PAPANNA, RAMESHA  (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: 10 year old;Address;Affect;Age Months;Allografting;Amniotic Fluid;Anatomy;Anterior Horn Cells;Anti-Inflammatory Agents;Arachnoid mater;Astrocytes;astrogliosis;Axon;axon injury;Biocompatible Materials;Biological;Biological Models;Birth;Blinded;Blood;caregiver quality of life;Cattle;Cell Count;Cells;Cerebrospinal Fluid;Child;Cicatrix;Clinical;Clinical Trials;Clinical/Radiologic;Collagen;comorbidity;contrast enhanced;cost;Cryopreservation;Data;Defect;Deterioration;Development;Diffusion Magnetic Resonance Imaging;disability;Disease;Dura Mater;Economic Burden;Extravasation;FDA approved;fetal;Fostering;Foundations;functional outcomes;Goals;Growth;Health;Histologic;Human;Hyaluronic Acid;improved;improved outcome;in utero;Incidence;independent ambulation;indexing;Infiltration;Inflammation;Inflammatory Response;innovation;insight;Label;Life;Live Birth;loss of function;Magnetic Resonance Imaging;Maintenance;Measures;Meningeal;Meningomyelocele;Methodology;Methods;Mission;Morbidity - disease rate;mortality;Natural regeneration;Nerve;Nervous System Physiology;neural;Neurologic;Neurological outcome;novel;novel strategies;Operative Surgical Procedures;Outcome;Pain;Patients;pre-clinical;preclinical study;Pregnancy;pressure;prevent;Process;Property;protective effect;Public Health;Publishing;Quality of life;Radiology Specialty;regenerative;regenerative repair;repaired;Reporting;Research;Research Personnel;School-Age Population;sheep model;Site;Skin;skin patch;Spinal Cord;Spinal cord injury;Spinal Dysraphism;standard of care;Subarachnoid Space;success;Syringomyelia;Techniques;Testing;Texas;Therapeutic;Time;Tissues;Traction;Treatment Efficacy;Umbilical cord structure;United States;United States National Institutes of Health;Vertebral column;Walking;Work

PROJECT_TITLE: Human Umbilical Cord as a Regenerative Meningeal Patch to Prevent Tethering and Improve Neurological Function Following In-Utero Spina Bifida Repair

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Aging;Cancer;Genetics;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE The biological mechanisms that drive genetic susceptibility to ovarian cancer are not well understood. This grant will use ultra-sensitive sequencing to characterize with high resolution TP53 mutations in fallopian tube during normal aging and in women with susceptibility to ovarian cancer to determine whether elevated risk of ovarian cancer is associated with increased somatic TP53 clonal evolution. This research will increase our understanding of ovarian carcinogenesis and enable to develop better strategies for ovarian cancer prevention and prediction.

PI_NAMEs: RISQUES, ROSA ANA  (contact)

PROJECT_TERMS: Age;age difference;Aging;Autopsy;Biological;Biopsy;Blood;BRCA1 gene;BRCA1 Mutation;cancer genetics;carcinogenesis;Cells;Centenarian;Clonal Evolution;Clonal Expansion;Clonality;Clustered Regularly Interspaced Short Palindromic Repeats;Collecting Tube;Constitution;Coupled;Data;Detection;Disease;Distal;DNA;driver mutation;Early Diagnosis;early screening;Environmental Risk Factor;Evaluation;Excision;Frequencies;Gene Order;General Population;Genetic Predisposition to Disease;Genetic Risk;Germ Lines;Germ-Line Mutation;Goals;Grant;Gynecologic;high risk;High Risk Woman;Histologic;Human;improved;Incidence;Incidental Findings;Knowledge;Lesion;Life;life span;lifetime risk;Location;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Methods;mutant;Mutation;mutation carrier;Natural History;Nature;neoplastic;Newborn Infant;normal aging;Normal tissue morphology;novel;Operative Surgical Procedures;Organ;Ovarian;ovarian cancer prevention;Ovary;overexpression;Pap smear;Pathogenesis;Pathogenicity;Pathologic;Peritoneal Fluid;Peritoneum;Population Process;Positioning Attribute;Predisposition;prevent;Process;prophylactic;Proteins;Recommendation;Reporting;repository;Research;Resolution;Risk;Risk Reduction;risk variant;Role;Salpingo-Oophorectomy;Sampling;Serous;Site;Testing;Tissues;TP53 gene;trait;tumorigenesis;Woman

PROJECT_TITLE: Understanding the role of TP53 mutation in genetic susceptibility to ovarian cancer

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Although tyrosine kinase inhibitors (TKis) such as imatinib revolutionized the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) and chronic myeloid leukemia (CML), the TKis will not eradicate leukemia in majority of patients. We propose to test completely novel anti- Ph+ALL/CML approach involving targeting the DNA polymerase theta to induce “synthetic lethality” in leukemia stem cells, while sparing normal counterparts. Our findings may have broad application to treat other tumors displaying specific defects in DNA repair mechanisms.

PI_NAMEs: SKORSKI, TOMASZ  (contact)

PROJECT_TERMS: ABL1 gene;Accelerated Phase;acute lymphoblastic leukemia cell;Acute Lymphocytic Leukemia;Apoptotic;Award;Biological;Blast Phase;Bone Marrow;BRCA deficient;brca gene;BRCA1 gene;BRCA2 gene;cancer cell;Cell Proliferation;Cells;Chronic Myeloid Leukemia;Chronic Phase;Collaborations;Dasatinib;Data;Defect;design;Disease;DNA Double Strand Break;DNA lesion;DNA Repair;DNA Repair Pathway;DNA-dependent protein kinase;DNA-Directed DNA Polymerase;DNA-PKcs;Double Strand Break Repair;Genetic;Genetic Transcription;Hematopoietic stem cells;homologous recombination;Imatinib;Immunodeficient Mouse;improved;improved outcome;In Vitro;in vivo;inhibitor;leukemia;Leukemic Cell;leukemic stem cell;leukemogenesis;LIG4 gene;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Mediating;Modality;mutant;Mutation;new therapeutic target;Nonhomologous DNA End Joining;novel;novel therapeutics;Oncogenic;Pathway interactions;Patients;peripheral blood;personalized medicine;Ph+ ALL;pharmacologic;Philadelphia Chromosome;Philadelphia Chromosome Positive Chronic Myelogenous Leukemia;Phosphotransferases;Play;precision medicine;Proliferating;Protein Tyrosine Kinase;Proto-Oncogene Proteins c-abl;RAD52 gene;Refractory;repaired;Reporting;Research Support;Resistance;response;Role;Signal Transduction;Somatic Mutation;Testing;Therapeutic;Therapeutic Effect;tumor;Tyrosine Kinase Inhibitor;Work;Xenograft procedure

PROJECT_TITLE: Targeting DNA repair to eradicate TKi-refractory/resistant CML and Ph+ALL


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Vaccine Related

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE This is a competing renewal application for a D43 Fogarty International Center-sponsored Global Infectious Disease Research Training Program in Vaccine Development and Public Health between the International Centre for Diarrhoeal Disease Research in Dhaka, Bangladesh (icddr,b), and the Massachusetts General Hospital (MGH) in Boston. The program focuses on long-term training in laboratory sciences and public health, includes both degree and non- degree programs, and provides individual and institutional capacity building in Bangladesh. The program builds upon ongoing and active scientific collaborations between the icddr,b and MGH, including on Vibrio cholerae, typhoid fever, and enteric infections, as well as adding training in respiratory infections and emerging pathogens, with a goal of continuing to build local capacity in biomedical investigation of host-pathogen interactions and vaccine development in Bangladesh.

PI_NAMEs: QADRI, FIRDAUSI ;RYAN, EDWARD T. (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Bangladesh;Bangladeshi;Biochemistry;Boston;career development;Collaborations;Communicable Diseases;Country;Diarrhea;Disease;Doctor of Philosophy;experience;Faculty;Fogarty International Center;Funding;General Hospitals;Goals;Grant;Head;Immunology;Individual;Infectious Diseases Research;institutional capacity;International;international center;Investigation;Laboratories;Laboratory Research;Massachusetts;Master of Public Health;Master of Science;member;Mentors;Molecular Biology;Postdoctoral Fellow;pre-doctoral;programs;Public Health;Public Health Schools;Research;Research Personnel;Research Training;respiratory;Science;Senior Scientist;Training;Training Programs;Tropical Disease;United States National Institutes of Health;Universities;vaccine development;Viral

PROJECT_TITLE: International research training program in vaccine development and public health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Z(55)R]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: Los Altos

ORG_NAME: BACSTITCH DNA INC.

PHR: PROJECT NARRATIVE Hypothesis-driven biomedical research often requires the de novo generation of gene-length or longer DNA constructs. However, existing DNA assembly technologies require considerable hands-on time and are difficult to multiplex and scale. The goal of this proposal is to develop a new in vivo gene assembly technology that will both increase the throughput and reduce the cost of long DNA construction.

PI_NAMEs: LEVY, SASHA F (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TERMS: Bacteria;Bacterial Artificial Chromosomes;base;Biomedical Research;Cells;Cloning;Complex;cost;Detection;DNA;DNA biosynthesis;DNA Library;Elements;Escherichia coli;frontier;gene synthesis;Generations;Genes;Genetic;Genome;Genomics;Goals;In Vitro;in vivo;incremental cost;Individual;Learning;Length;Libraries;Liquid substance;Methods;Modality;new technology;novel;Oligonucleotides;Open Reading Frames;Operon;Output;Partner in relationship;Pathway interactions;Phase;Plasmids;Polymerase;Positioning Attribute;Printing;Procedures;Process;Production;Regulatory Element;Robot;Series;Services;synthetic biology;System;Techniques;Technology;technology development;Testing;Time;Variant;Vendor;Work;Yeasts

PROJECT_TITLE: Multiplexed In Vivo DNA Assembly


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: BINGHAMTON

ORG_DEPT: CHEMISTRY

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Project Narrative: Experimental insight into the mechanism of organic reactions is critical for the rational design of new and improved methodologies for the synthesis of medicinally relevant organic molecules. This proposal addresses this integral need by utilizing experimental and computational approaches to understand reaction mechanisms in two emerging areas of catalysis where new reaction discovery has far outpaced mechanistic understanding – (a) the conversion of abundant carbon-hydrogen bonds to valuable new carbon- carbon bonds commonly known as C-H functionalization; and (b) methodologies that combine nickel and photocatalysts to forge valuable new carbon-carbon or carbon-heteroatom bonds from inexpensive precursors.

PI_NAMEs: VETTICATT, MATHEW J (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Mechanistic Studies at the Frontiers of Catalysis