NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Primary Health Care

ORG_CITY: NEW YORK

ORG_NAME: HUNTER COLLEGE

PHR: 8. PROJECT NARRATIVE This project applies an implementation science approach to support the federal Ending the HIV Epidemic “protect” goal by developing biobehavioral infrastructure (i.e., empirically rigorous knowledge, guidelines, tools) that will support expansion of effective PrEP delivery programs and promote health equity in the dissemination of emerging biomedical HIV prevention strategies. This project is a collaboration among researchers, technical assistance providers, and front-line clinical staff to develop tools and metrics that enhance best practice in the field.

PI_NAMEs: GOLUB, SARIT A (contact);MEYERS, KATHRINE

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: Acceleration;Address;Adherence;Age;AIDS prevention;Behavior;biobehavior;Characteristics;Clinic;Clinical;clinical development;clinical practice;clinical research site;Clinical Trials;Collaborations;Communicable Diseases;Country;County;Data;Data Collection;Data Reporting;data standards;design;Development;Diffusion;Disparate;Drug Delivery Systems;Drug Formulations;Eligibility Determination;Ensure;Epidemic;Equity;Ethnic Origin;evidence base;flexibility;Formulation;Funding;Future;future implementation;Gender;Geographic Locations;Geography;Goals;Guidelines;health equity;health equity promotion;HIV;implementation efforts;implementation fidelity;implementation outcomes;implementation science;implementation tool;improved;Individual;Infrastructure;innovation;Intervention;Knowledge;Literature;Measures;Medicaid;Methods;Modality;Modeling;Monitor;novel;Online Systems;Oral;Outcome;Output;patient population;Patients;Phase;Policies;Population;pre-exposure prophylaxis;Prevention;prevention service;Prevention strategy;Primary Care;Process;programs;Provider;Public Health;Race;Research;Research Personnel;response;school based health center;screening;Seminal;service delivery;Service delivery model;sexual identity;Site;Specific qualifier value;Speed;Standardization;success;System;Telemedicine;Testing;Theoretical model;Time;tool;Training;uptake;Work

PROJECT_TITLE: Synthesizing Best Practice to Accelerate Access to Emerging HIV Prevention Modalities

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease;Palliative Care

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative This training program aims to engage and train the next generation of kidney researchers. SRIP-Kid students will attend didactic lectures, lab courses and hands on lab experience at the hands of world-class researchers in one of the most prolific and exciting research institutions in the country. We will attempt to train between 13- 15 students per year for the duration of the grant.

PI_NAMEs: HO, JACQUELINE ;SIMS-LUCAS, SUNDER  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Accounting;Acute;Acute Renal Failure with Renal Papillary Necrosis;Adult;Affect;American;Anatomy;career;Child health care;Childhood;Chronic Kidney Failure;Clinical;cost;Country;Critical Care;Dialysis procedure;Disease;diversity and inclusion;Doctor of Philosophy;Education;Educational Activities;Educational workshop;effective therapy;Electrolytes;End stage renal failure;Exposure to;Faculty;faculty research;follow-up;Funding;Future;Goals;Grant;Hand;Health Care Costs;Healthcare;Hospitalization;Hour;Infrastructure;innovation;Institution;interest;International;Internships;journal article;Kidney;Kidney Diseases;Kidney Transplantation;Laboratories;laboratory experience;lectures;Medical Research;medical schools;medical specialties;Medicine;member;Mentors;Mentorship;Methods;Monitor;Morbidity - disease rate;mortality;Multimedia;National Institute of Diabetes and Digestive and Kidney Diseases;nephrogenesis;Nephrology;next generation;novel;Oral;Palliative Care;Paper;Participant;patient oriented research;Patients;Pediatric Hospitals;Physiology;Population Heterogeneity;Positioning Attribute;programs;Records;recruit;Research;Research Personnel;Research Project Grants;Research Training;Risk;Scientist;social media;student mentoring;Students;summer program;summer research;symposium;Teacher Professional Development;Training;Training Programs;Translations;undergraduate student;Underrepresented Minority;Underrepresented Students;United States National Institutes of Health;Universities;university student;web site;Work

PROJECT_TITLE: The University of Pittsburgh Summer Research Internship Program kidney workshop (SRIP-Kid)

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE  The efficacy of chemotherapy against solid tumors depends on the status of type I interferon receptor (IFNAR1). Pilot studies reveal that, in colorectal cancers (CRC), tumor microenvironment stress and tumor-derived factors downregulate IFNAR1 thereby potentially rendering CRC refractory to chemotherapy. Studies proposed here will determine the importance of IFNAR1 loss in decreased sensitivity of CRC to chemotherapy and examine the benefits of combining chemotherapeutics with agents reactivating the IFNAR1 pathway to increase the efficacy of CRC treatment.

PI_NAMEs: FUCHS, SERGE Y (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Affinity;anti-cancer treatment;Anti-Hypertensive Agents;anti-tumor immune response;Antineoplastic Agents;antitumor effect;Benign;Binding;Cell surface;Cells;chemotherapy;Chemotherapy-Oncologic Procedure;colon cancer patients;Colorectal Adenocarcinoma;Colorectal Cancer;colorectal cancer treatment;cytokine;Data;density;Disease;Down-Regulation;efficacy evaluation;Endocytosis;Epithelial Cell Proliferation;Epithelial Cells;Exhibits;experimental study;extracellular vesicles;Family;Fluorouracil;Genes;Human;IFNAR1 gene;IFNAR2 gene;inhibitor;Interferon alpha;Interferon Type I;Interferons;intestinal epithelium;Knock-in Mouse;Malignant - descriptor;Malignant Neoplasms;Mediating;mutant;neoplastic cell;novel;Pathway interactions;Persons;pharmacologic;Phosphorylation;Pilot Projects;Play;preclinical study;prevent;Production;Proliferating;Proteins;Public Health;Publishing;Radiation therapy;receptor;Recombinants;refractory cancer;Regimen;Reserpine;response;Role;small molecule;Solid Neoplasm;standard of care;STAT1 gene;Stress;Sumoylation Pathway;targeted cancer therapy;Testing;Therapeutic;Treatment Efficacy;Treatment Protocols;tumor;tumor microenvironment;Tumor-Derived;tumorigenic;type I interferon receptor;Ubiquitination;uptake;Vesicle;Work

PROJECT_TITLE: Reactivation of type I interferon pathway to increase the efficacy of chemotherapy

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Depression;Drug Abuse (NIDA only);Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BUTLER HOSPITAL (PROVIDENCE, RI)

ORG_STATE: RI

PHR: PUBLIC HEALTH NARRATIVE Cannabis is the most widely used drug among pregnant women, and rates of use are increasing steadily, in spite of medical recommendations to avoid cannabis during pregnancy. Although many women seek to reduce their use when pregnant, few support options exist. Physical activity interventions can improve mood and provide a healthy option for coping with urges to use substances; this study will develop a prenatal physical activity program designed to help women avoid cannabis use during pregnancy.

PI_NAMEs: BATTLE, CYNTHIA L. (contact)

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: Abstinence;acceptability and feasibility;Addictive Behavior;Address;adverse maternal outcomes;adverse outcome;alcohol abuse therapy;Alcohol consumption;Anxiety;anxiety symptoms;Birth;Cannabis;Child;Clinical;coping;Coping Skills;cost;Counseling;craving;Data;Depressed mood;depressive symptoms;design;Development;Distress;Dropout;Drug usage;Educational Intervention;effective intervention;Effectiveness;Emotional;exercise intervention;Exhibits;experience;Feeling;fitbit;fitness;flexibility;follow-up;Future;Goals;Health Status;high risk;High Risk Woman;Household;improved;Individual;infant outcome;Intervention;Interview;Lactation;Life;Life Style;Light;Low Birth Weight Infant;Manuals;marijuana use;marijuana use in pregnancy;Mediating;Medical;Mental Depression;Monitor;Moods;Mothers;Nausea;negative affect;novel;Outcome;Pain;Participant;Patient Self-Report;perinatal cannabis use;perinatal period;perinatal women;Phase;Physical activity;physical symptom;pilot test;pilot trial;Play;Postpartum Period;Pregnancy;pregnant;Pregnant Women;Premature Birth;prenatal;prevent;primary outcome;Process;Program Acceptability;programs;Psyche structure;psychopharmacologic;Public Health;randomized trial;Recommendation;Recording of previous events;Relapse;Research;Risk;Risk Reduction;Safety;secondary outcome;Self Efficacy;Structure;substance use;Substance Use Disorder;Symptoms;Technology;Testing;therapy development;Time;Tobacco;Treatment Efficacy;vigorous intensity;Walking;Woman

PROJECT_TITLE: Development of a lifestyle physical activity intervention to reduce risk for perinatal cannabis use

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Digestive Diseases;Neurosciences;Precision Medicine;Rehabilitation

ORG_CITY: SAN DIEGO

ORG_NAME: CALIFORNIA MEDICAL INNOVATIONS INSTITUTE

ORG_STATE: CA

PHR: NARRATIVE Defecatory disorders are common but diagnostics and therapy are challenging. Our goal is to monitor and predict responders of biofeedback therapy for patients with obstructed defecation by using a new electronic simulated stool (Fecobionics) for visualizing geometric and manometric patterns before and during defecation. The successful completion of this proposal may lead to development of new treatment of anorectal disorders.

PI_NAMEs: GREGERSEN, HANS  (contact);KASSAB, GHASSAN S

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Abdomen;Affect;Aftercare;Aging;American;anorectal disorder;Area;Ataxia;Biofeedback Training;Biomechanics;Bionics;Chronic;Classification;Clinical Management;clinical practice;Clinical Trials;Constipation;cost;Cost Savings;Data;data integration;Defecation;Defecography;Defect;Development;Devices;Diagnosis;Diagnostic;Diagnostic tests;Diet;Dimensions;Disease;Electronics;Exercise;Expenditure;Fecal Incontinence;Feces;Friends;Goals;graphical user interface;healthcare burden;Healthcare Systems;High Prevalence;Home;improved;Incidence;indexing;Individual;innovation;insight;Intestines;Lateral;laxative;Length;Liquid substance;Magnetic Resonance Imaging;Manometry;Maps;Measurement;Medicine;Monitor;Muscle;neuromuscular;new technology;novel;optimal treatments;Outcome;outcome prediction;Patients;Pattern;Pelvic Floor Muscle;Pelvic floor structure;Pelvis;Physiological;Physiology;Play;point of care;Population;Positioning Attribute;Posture;pressure;Procedures;Process;programs;Property;Quality of life;Radiation;randomized trial;Reaction;Records;Rectum;Research;Resolution;responders and non-responders;response;Rest;Risk;Role;Sensory;Shapes;Specialized Center;sphincter ani muscle structure;success;Symptoms;System;Technology;Test Result;Testing;therapy outcome;Time;tool;Training;Treatment outcome;treatment responders;visual feedback;Visualization;Water

PROJECT_TITLE: Fecobionics monitoring and prediction of biofeedback therapy outcome in patients with obstructed defecation.

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: This research is relevant for Veterans, as stroke is one of the leading causes of long-term disability in Veterans. An estimated 15,000 Veterans suffer a stroke each year. A novel rehabilitation treatment option developed as a result of this research has the potential to reduce the consequences of stroke for Veterans. Therefore, the proposed research is expected to contribute to providing Veterans with better post-stroke rehabilitation care with improved performance for activities of daily living.

PI_NAMEs: SEO, NA JIN  (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Agonist;antagonist;Brachial Paresis;Caregiver Burden;chronic stroke;computer game;Computers;Control Groups;Coupling;Data;Distal;Dose;Employment;Evaluation;experience;Extensor;Fingers;Flexor;follow-up;grasp;Hand;hand dysfunction;Impairment;improved;Intuition;Life Style;Limb structure;Linear Models;Long term disability;Maps;Measures;Motion;Motor;motor control;motor impairment;Movement;Muscle;Neurologic;Neuromechanical Changes;novel;Outcome;Paresis;Pattern;Performance;Physiological;Play;post intervention;post stroke;Principal Component Analysis;Quality of life;Randomized;Randomized, Controlled Trials;Rehabilitation Outcome;Rehabilitation therapy;rehabilitative care;Research;Research Design;Self Care;Signal Transduction;Social Interaction;Source;Statistical Data Interpretation;Stroke;stroke survivor;System;Testing;Therapeutic;Time;Training;treatment group;two-dimensional;Upper Extremity;Veterans;Visualization

PROJECT_TITLE: EMG-Controlled Game to Retrain Upper Extremity Muscle Activation Patterns Following Stroke

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The inability to appropriately switch behavior in different environments is common in conditions such as schizophrenia, dementia, and Alzheimer's disease. The proposed research seeks to define the inhibitory and excitatory neuronal circuits that dynamically respond when animals enter novel environments and test their functional roles in goal-oriented behavior. The results may lay the groundwork for neuronal circuit-targeted approaches to restore context-appropriate behaviors that have potential implications for the treatment of cognitive impairment associated with many mental disorders and neurodegenerative diseases.

PI_NAMEs: HAN, EDWARD BING (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Alzheimer's Disease;Animals;Automobile Driving;Behavior;behavior change;Behavior Therapy;behavioral impairment;Brain;Calcium;cell type;Cells;Classification;Code;Cognition Disorders;Cues;Data;Dementia;Disinhibition;Environment;excitatory neuron;experimental study;Foundations;goal oriented behavior;Goals;Head;hippocampal pyramidal neuron;Hippocampus;Human;Image;Immunofluorescence Immunologic;Impaired cognition;in vivo;in vivo calcium imaging;Individual;inhibitory neuron;Interneurons;Kinetics;Link;Location;Maps;Mental disorders;Microscopy;Modification;Motivation;Mus;Network-based;neural circuit;neural network;Neurodegenerative Disorders;neuronal circuitry;Neurons;novel;Parvalbumins;Play;Population;Positioning Attribute;Punishment;Recovery;Research;restoration;Rewards;Role;Schizophrenia;Somatostatin;Structure;System;Task Performances;Testing;Time;Titrations;virtual reality;virtual reality environment;Visualization;Water;Work

PROJECT_TITLE: Neural circuit mechanisms for goal-oriented behavior in novel environments

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Nanotechnology;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Narrative. In this proposal we will develop and optimize theranostic PSMA-targeted gold nanoparticle that act as a MR contrast agent as well as a radio-sensitizer. We will design, synthesize, characterize and optimize the utility of the particles in vitro and then utilize them for MR-guided radiotherapy in mice. These studies will lay the groundwork for this technology to be used for other cancers that express PSMA.

PI_NAMEs: AYDOGAN, BULENT ;BASILION, JAMES PETER (contact);MEADE, THOMAS J

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Ablation;Address;Affinity;Anatomy;Antigen Targeting;Biodistribution;Biological;Calibration;cancer cell;cancer diagnosis;Cancer Patient;Cancerous;Cells;Chicago;Clinical;clinical investigation;clinical translation;combat;Complex;Conformal Radiotherapy;contrast enhanced;contrast imaging;Contrast Media;Contrast Sensitivity;Dedications;design;Development;Devices;Diagnosis;Diagnostic Imaging;Discrimination;Disease;DNA strand break;Dose;Dose Limiting;Drug Delivery Systems;Electrons;Excision;experience;FOLH1 gene;Gadolinium;Goals;Gold;Histologic;image guided;image guided radiation therapy;Implant;Impotence;improved;In Vitro;in vivo;Incontinence;Individual;Intensity-Modulated Radiotherapy;Investigation;irradiation;Ligands;Low Dose Radiation;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;men;Methods;mitochondrial dysfunction;mortality;Mus;Muscle;Muscle Cells;Muscle Fibers;nano;nanocluster;nanoGold;nanoparticle;neoplastic cell;neovasculature;Nerve;Nerve Fibers;Neurons;next generation;Normal Cell;Normal tissue morphology;novel;Nude Mice;off-target site;Operative Surgical Procedures;Organ;particle;Patient observation;Patients;Positioning Attribute;pre-clinical;Prostate;Prostate Ablation;prostate cancer cell;prostate cancer cell line;prostate cancer model;Prostate Cancer therapy;Prostatectomy;Prostatic Neoplasms;Qualifying;Radiation;Radiation Dose Unit;radiation effect;Radiation therapy;Radiation-Sensitizing Agents;Radical Prostatectomy;Radiosensitization;Recurrence;Research;response;Screening for Prostate Cancer;Serum;side effect;soft tissue;Solid Neoplasm;Structure;success;Surface;targeted imaging;Technology;Testing;theranostics;therapeutic evaluation;therapy development;therapy outcome;Tissues;Toxic effect;tumor;Tumor Burden;tumor growth;tumor progression;United States;uptake;Visualization;x-ray irradiation

PROJECT_TITLE: PSMA-targeted AuNPs for MR guided radiotherapy and radiosensitization

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: Project Narrative Biological crystallography and spectroscopy are complementary methods that contribute to understanding the structure and function of enzymes. The newly available X-ray Free Electron Laser facilities have made possible the study of biological molecules at room temperature, as the reactions proceed in real time. Development of both crystallography and spectroscopy methods that make use of this novel transformative tool is important for understanding how complex biological molecules, like metal-containing proteins, function at physiological temperatures.

PI_NAMEs: YANO, JUNKO  (contact)

PROGRAM_OFFICER_NAME: SINHA, SANGITA C

PROJECT_TERMS: absorption;Active Sites;analog;Binding;Biochemical Reaction;Biological;biological systems;Biology;catalyst;Catalytic Domain;Charge;Chemical Dynamics;Chemicals;Chemistry;cofactor;Collaborations;Complex;copper oxidase;cryogenics;Crystallography;Cytochrome P450;Data;Data Analyses;Data Collection;Data Correlations;design;Development;Diffusion;Electron Transport;electronic structure;Electronics;Electrons;Elements;emission spectroscopy;Engineering;Environment;enzyme structure;Enzymes;Event;Evolution;experimental study;flexibility;Fluorescence;Generations;geometric structure;Geometry;Goals;Heme;Homo;Hydrogen Bonding;Hydrogenase;Hydroxyl Radical;In Situ;insight;interest;isopenicillin N;Kinetics;Measurement;Membrane;metal complex;metallicity;metalloenzyme;Metalloproteins;Metals;Methane;Methane hydroxylase;Methane Metabolism Pathway;Methodology;Methods;Monitor;Mononuclear;Nature;novel;novel strategies;Nuclear;Oxidases;oxidation;Oxidation-Reduction;Oxidoreductase;Oxygen;Oxygenases;Physiologic pulse;Physiological;Property;Protein Dynamics;protein structure;Proteins;Protocols documentation;Protons;Radiation induced damage;Reaction;Resolution;Ribonucleotide Reductase;Roentgen Rays;Sampling;Signal Transduction;Site;Source;Specificity;spectroscopic data;Spectrum Analysis;Speed;Structure;Synchrotrons;System;Techniques;Temperature;Time;tool;Transition Elements;Visualization;Water;Width;X ray diffraction analysis;X ray spectroscopy;X-Ray Crystallography;x-ray free-electron laser;Xray Emission Spectroscopy

PROJECT_TITLE: Biological Spectroscopy and Crystallography Using an X-ray Free Electron Laser


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Regenerative Medicine;Wound Healing and Care

ORG_CITY: WASHINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE  Therapeutic strategies that target the proliferative phase of skin repair with growth factors and cytokines have shown little progress in the treatment of chronic, non-healing wounds. Our study focuses on dissecting the mechanism that allows a lipid signaling pathway (GPR84) to regulate inflammatory macrophage numbers and supports subsequent tissue repair. These findings hold the potential inform new ways to treat non-healing wounds.

PI_NAMEs: SHOOK, BRETT  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acute;acute wound;Adipocytes;aged;Aging;Agonist;antagonist;Biology;Bone Marrow;Cell Count;Cell Physiology;cell type;Cells;Cellular biology;Chronic;Communication;Complex;cytokine;Data;Dermal;Development;Diabetes Mellitus;diabetic;Disease;Epithelial Cells;Epithelium;experimental study;Foundations;G-Protein-Coupled Receptors;Gene Expression;Gene Expression Profile;Genetic;Genetic Models;genomic tools;Genomics;Goals;GPR84 gene;Growth Factor;healing;immune cell infiltrate;Impaired healing;Impaired wound healing;In Vitro;in vitro Assay;in vivo;Inflammation;Inflammatory;Inflammatory Response;Injury;insight;keratinocyte;Knockout Mice;Learning;Link;Lipids;Lipolysis;LoxP-flanked allele;Macrophage;Medium chain fatty acid;migration;Molecular;mouse model;Mus;Myelogenous;Myeloid Cells;non-healing wounds;novel;Pathologic;Patients;pharmacologic;Phase;Populations at Risk;predictive tools;Process;Proliferating;Qualifying;receptor;recruit;Regulation;repaired;reparative process;response to injury;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;Skin repair;Skin wound healing;small molecule;Solid;stem cells;Stromal Cells;System;targeted treatment;Testing;Therapeutic;Therapeutic Uses;tissue repair;Tissues;tool;Work;wound;wound bed;wound healing;wound treatment

PROJECT_TITLE: The role of GPR84 signaling during skin repair

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Corneal diseases continue to be a major health problem in the US, and many of these diseases result in permanent damage to the corneal nerves, leading to a dysfunctional cornea. Given the increasing incidence of corneal diseases, it is imperative to understand the molecular mechanisms involved in corneal nerve regeneration and identify novel therapeutic targets. Glutamate receptors, such as N-Methyl-D-aspartate receptors (NMDAR), have been shown to enhance nerve regeneration in other analogous systems, and, therefore, this proposal will use novel genetic, molecular, and therapeutic approaches to study and define the role of NMDAR in corneal nerve regeneration and its potential as a novel drug target.

PI_NAMEs: LEE, VIVIAN  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Address;afferent nerve;Afferent Neurons;Agonist;antagonist;Architecture;aspartate receptor;AVIL gene;Axotomy;Biological Markers;Biology;Cellular biology;Chemicals;Cochlea;Complex;Cornea;Corneal Diseases;corneal epithelial wound healing;Data;density;Development;Disease;EphB2 Receptor;experimental study;Functional disorder;Future;Gene Expression;Genetic;Genetic Transcription;Genomics;Glaucoma;Glutamate Receptor;glutamatergic signaling;Goals;Growth;Growth Factor;Health;Histology;Homeostasis;Immunohistochemistry;in vivo;in vivo imaging;in vivo regeneration;Incidence;Infection;injured;Injury;innovation;insight;intravital imaging;Knockout Mice;LDL-Receptor Related Protein 1;Maintenance;Mechanics;Mediating;Metabolic;Methods;Modeling;Molecular;Monitor;Morphology;mouse genetics;mouse model;Mus;N-Methyl-D-Aspartate Receptors;Natural regeneration;Nerve;Nerve Fibers;Nerve Regeneration;nerve supply;nerve transection;Nervous System;Neuronal Plasticity;Neurons;new therapeutic target;novel;novel strategies;ocular surface;Operative Surgical Procedures;Optic Nerve;Outcome;Pain;Pathway interactions;Peripheral;peripheral nerve regeneration;Peripheral Nervous System;pharmacologic;Positioning Attribute;Predisposition;Protein Tyrosine Kinase;Proteins;Publishing;regenerative;restoration;Retina;Role;Schwann Cells;sciatic nerve;Signal Transduction;Signaling Molecule;Stimulus;Structure;Supporting Cell;System;Tamoxifen;targeted treatment;Temperature;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy development;Time;Tissues;transcriptomics;Trauma;Trigeminal nerve structure;Trigeminal System;two photon microscopy;Work;wound healing

PROJECT_TITLE: New models, new approaches, new horizons in corneal nerve regeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: We propose to assess the diagnostic power of a liquid biopsy for glioma detection and treatment monitoring. Specifically, we will advance a clinical assay for comprehensive, high-throughput molecular profiling of extracellular vesicles (EVs). The developed assay will be applied to analyze patient blood samples. EVs' clinical utility will be integrated with standard imaging (MRI).

PI_NAMEs: BALAJ, LEONORA  (contact);LEE, HAKHO

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Address;Adopted;biobank;Bioinformatics;Biological Assay;Biological Markers;Biopsy;Blood specimen;Brain Neoplasms;cancer biomarkers;cancer cell;Caring;Cell Line;Cells;Central Nervous System;Cessation of life;chemotherapy;Clinical;clinical care;clinical diagnostics;Clinical Protocols;Clinical Research;clinical translation;cohort;comorbidity;comparative efficacy;Data;design;Detection;Development;Diagnosis;Diagnostic;diagnostic strategy;diagnostic value;digital;Disease;Drug resistance;Early Diagnosis;Ensure;Evolution;Excision;exosome;experience;extracellular vesicles;follow-up;General Hospitals;Glioma;Goals;Heterogeneity;Human;Image;improved;individualized medicine;Industry;innovation;instrument;Laboratories;liquid biopsy;Longitudinal Studies;Magnetic Resonance Imaging;Malignant Glioma;Malignant Neoplasms;Massachusetts;Mean Survival Times;Measures;Membrane;Messenger RNA;Methods;minimally invasive;Modeling;Molecular;Molecular Analysis;Molecular Profiling;molecular subtypes;Monitor;mRNA Expression;multidisciplinary;nanoscale;new technology;novel;Nucleic Acids;Operative Surgical Procedures;Outcome;Outcomes Research;particle;patient stratification;Patients;Performance;peripheral blood;plasmonics;predictive modeling;pressure;prognostic;programs;Progression-Free Survivals;Protein Analysis;Proteins;Quality Control;Radiation therapy;Readiness;Regression Analysis;Reproducibility;Resistance;Resistance development;Resources;Risk;Sampling;Sampling Biases;Sampling Errors;screening;Specificity;Specimen;Standardization;statistics;success;Systems Biology;technology validation;temozolomide;Testing;therapy resistant;Time;Tissues;tool;translational impact;Translations;Treatment outcome;treatment response;treatment strategy;tumor;Tumor Burden;tumor heterogeneity;tumor progression;Vesicle

PROJECT_TITLE: Imaging and Liquid Biopsy for Glioma Diagnosis and Treatment Monitoring

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Inflammatory Bowel Disease;Nutrition;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE: New strategies that would be safe, effective, and inexpensive are greatly needed for the treatment of inflammatory bowel disease (IBD) and prevention of the colorectal cancer that frequently arises in patients with IBD. We have spearheaded investigations about molecules called polyamines, and one of these molecules, spermidine, is a natural product that appears from our data to have exciting potential as a treatment for inflammation of the colon and for prevention of cancer. In order to gain insights needed for future human clinical trials, we will undertake novel studies using genetically engineered mouse models and sophisticated molecular methodologies to determine how spermidine is beneficial, studying effects on cells of the immune system and the cells that line the colon, and by detoxifying highly reactive, injurious molecules that could otherwise damage proteins and DNA within cells of the colon and lead to cancer.

PI_NAMEs: WILSON, KEITH T. (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Acute;Address;adduct;Affect;Aging;American;Amino Acids;Animals;Arginine;Autophagocytosis;Azoxymethane;Back;Biological;Biological Assay;cancer chemoprevention;cancer prevention;cancer risk;carcinogenesis;Carcinoma;cardiovascular health;Cell Line;Cell Physiology;Cells;Chemopreventive Agent;Chronic;Clinical;Clinical Trials;Colitis;Colon;colon carcinogenesis;Colonic inflammation;colorectal cancer prevention;Crohn's disease;Data;deoxyhypusine synthase;Detection;dextran sulfate sodium induced colitis;DNA;drinking water;Drug Metabolic Detoxication;Dysplasia;Enzymes;Epithelial Cells;Epithelium;Eukaryotic Initiation Factors;Exhibits;Future;Generations;Genetically Engineered Mouse;Genomic Instability;Genomics;Goals;healing;High Pressure Liquid Chromatography;Histologic;Human;hypusine;Immune;Immune response;Immune system;Immune System Diseases;immunoregulation;improved;in vivo;Inflammation;Inflammatory Bowel Diseases;insight;Investigation;Lipid Peroxidation;liquid chromatography mass spectrometry;Longevity;Longitudinal Studies;Macrophage;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;Measurement;Mediating;Metabolism;metabolome;Methodology;Methods;Microbe;Modeling;Molecular;mRNA Expression;Mucosal Immune Responses;Mus;Myelogenous;Myeloid Cells;Natural Products;Neoplasms;neoplastic;novel;novel therapeutics;Oncogenic;Ornithine;Ornithine Decarboxylase;overexpression;Oxazolone;Patients;Persons;Phase I Clinical Trials;Plants;polyamine oxidase;Polyamines;Prevalence;Prevention;protective effect;Proteins;Public Health;Publishing;Putrescine;Quality of life;Reporting;response;Risk;Risk Reduction;Role;Severities;Signal Transduction;Sodium Dextran Sulfate;Source;Spermidine;Spermine;Supplementation;Testing;Tissue Microarray;Tissues;transcriptome;Transgenic Mice;Translating;Translations;treatment strategy;tumor;Tumor Immunity;tumorigenesis;Ulcerative Colitis

PROJECT_TITLE: Spermidine as a New Therapy for Colitis and Chemopreventive for Colitis-associated Carcinogenesis

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Patient Safety

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The University of Michigan participation as a Lead Academic Participating site (LAPS) is interdisciplinary with clinical investigators and basic research associates involved in the National Clinical Trials Network (NCTN) activities and membership in three of the four adult Cooperative Groups. This involvement in NCTN research is characterized by scientific, leadership and administrative contributions, robust accrual to NCTN trials, quality data management and protocol compliance.

PI_NAMEs: SCHOTT, ANNE F (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Adjuvant Therapy;Adoption;Adult;Advanced Malignant Neoplasm;anti-cancer research;Award;Awareness;Basic Science;cancer care;cancer therapy;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Collection;Comprehensive Cancer Center;Data;data management;Dedications;Development;Discipline;Ethics;Faculty;Goals;Grant;Healthcare Systems;improved;Institution;Laws;Lead;Leadership;medical schools;Mentors;Michigan;Modality;National Clinical Trials Network;participant enrollment;Patient-Focused Outcomes;Patients;Play;Policies;Postdoctoral Fellow;Process;Prognostic Factor;Protocol Compliance;Protocols documentation;rare cancer;Reporting;Research;Resources;response;Role;Site;Talents;therapy outcome;Toxic effect;Training;Translating;Universities;Veterans

PROJECT_TITLE: UM LAPs - UG1 Grant


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Pediatric;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Defects in proper trophoblast lineage development contribute substantially to early human pregnancy failure and other pregnancy-related conditions. However, the molecular mechanisms of human trophoblast differentiation remain poorly understood. The results from the proposed studies will expand our understanding of how cells in trophoblast lineages are modulated by global transcriptional regulatory networks, and reveal new factors not previously implicated in trophoblast development, catalyzing novel insights into human placentation and pregnancy-related disorders.

PI_NAMEs: KIM, JONGHWAN  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Biological Models;Biotinylation;Blood Vessels;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cytotrophoblast;Data;Defect;Development;Disease;early pregnancy;Economic Burden;Embryo;embryo cell;Enhancers;Epigenetic Process;Evaluation;Fetal Tissues;Foundations;Fractionation;Future;gain of function;gene regulatory network;Genes;Genetic Transcription;healthy pregnancy;Hematopoietic;Human;Human Development;Immunodeficient Mouse;Immunologics;implantation;In Vitro;in vivo;insight;Knock-in;Knowledge acquisition;Logic;loss of function;Maps;Mass Spectrum Analysis;Mediating;Modeling;Molecular;Molecular Biology;Mus;network models;novel;Organ;Outcome;Placenta;Placentation;Play;Pre-Eclampsia;Pregnancy;pregnancy failure;Property;protein complex;Proteins;Publishing;Regulatory Element;Research;Resources;Role;self-renewal;socioeconomics;Specific qualifier value;stem cell self renewal;Syncytiotrophoblast;System;Systems Biology;Testing;transcription factor;transcription regulatory network;trophoblast;trophoblast stem cell;Villous;Xenograft procedure

PROJECT_TITLE: Deciphering gene regulatory networks modulating human trophoblast stem cell self-renewal and differentiation

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Pediatric;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: COLLEGE STATION

ORG_DEPT: DENTISTRY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Project Narrative Our research proposal seeks to determine the novel role of tendon in TMJ formation, disease and trauma. Finishing this proposal will fill the knowledge gap in this largely unknown but vital area and lay the foundation for developing novel approaches for the diagnosis and treatment to TMJ disease and ankylosis.

PI_NAMEs: JING, YAN  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Acceleration;Adult;Animal Model;Ankylosis;Area;arthropathies;Biological;Birth;bone;bone cell;Bone Growth;Bone Spur;Bone Tissue;Buffers;Cartilage;cartilage cell;Cell Proliferation;cell type;Cells;Cellular Morphology;Child;Chondrocytes;Complex;craniofacial bone;Defect;Degenerative Disorder;Diagnosis;Disease;Epiphysial cartilage;Esthetics;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Face;Female;Foundations;Goals;Growth;Head;Heterotopic Ossification;High Prevalence;Human body;Hypophosphatemia;Ice;imaging modality;in vivo;injured;Injury;insight;Invaded;joint formation;joint injury;joint mobilization;Joint repair;Joints;Knowledge;life span;malformation;Mandibular Condyle;mechanical force;mineralization;Minerals;Muscle;Myofascial Pain Syndromes;Names;Natural regeneration;novel;novel strategies;Onset of illness;Operative Surgical Procedures;Oral cavity;Osteogenesis;Pain management;Patients;Pattern;Periosteum;Phosphorus;Physical therapy;Play;Population;postnatal;Practice Management;repaired;Research;Research Proposals;Rest;restoration;Role;scleraxis;Series;Site;skeletal;skeletal disorder;Source;Surgical Management;Temporal bone structure;Temporomandibular Joint;Temporomandibular Joint Disorders;Tendon structure;Testing;Tissues;TMD treatment;transdifferentiation;transmission process;Trauma;treatment strategy;Work

PROJECT_TITLE: Novel roles of tendon during TMJ postnatal growth and onset of diseases

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Prevention;Substance Misuse

ORG_CITY: MEMPHIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: One in eight adult Americans are alcoholics1, and more than 18 million Americans are estimated to have alcohol- related diseases and disorders (ADD), including hepatitis, pancreatitis, and neurodegenerative disorders. We propose to conduct studies to uncover the cellular and molecular mechanisms involved in alcohol-mediated multiple organ damage and identify calcium channels in the intestine as therapeutic targets for developing therapeutics for treating ADD. These studies are expected to determine the calcium channel blockers as potential therapeutic agents for the treatment of patients with ADD.

PI_NAMEs: RAO, RADHAKRISHNA  (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Acetaldehyde;Adrenal Cortex Hormones;Adult;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol misuse;alcohol prevention;Alcoholic liver damage;Alcoholic Liver Diseases;Alcohols;American;analog;apical membrane;Attenuated;Binding Sites;Caco-2 Cells;Calcium;Calcium Channel;Calcium Channel Blockers;CaT1 calcium channel;Cell Line;Cells;Cellular biology;channel blockers;Chronic;chronic alcohol ingestion;Clinical;Diltiazem;Disease;Endotoxemia;Epithelium;Ethanol;Feedback;Functional disorder;global health;Glucocorticoids;Goals;Hepatitis;Image;in vivo;inhibitor;intestinal barrier;intestinal epithelium;Intestinal permeability;Intestines;Ion Channel;knock-down;Knockout Mice;Link;Liver diseases;liver injury;Mass Spectrum Analysis;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Mus;Neurodegenerative Disorders;new therapeutic target;novel;novel therapeutic intervention;Organ;Organoids;Outcome Study;Pancreatitis;patch clamp;Patients;Permeability;pharmacologic;prevent;Prevention;Preventive;problem drinker;Qualifying;rational design;Resistance;response;Role;side effect;Structure;systemic inflammatory response;targeted treatment;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Tight Junctions;tissue injury;Tissues;Transgenic Mice;voltage

PROJECT_TITLE: Defining the Role of Intestinal Calcium Channels in Alcoholic Liver Damage.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(04)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Relevance As a LAPS, Yale University will continue its major contributions to the NCI supported National Clinical Trials Cooperative Group Program that has led and will continue to lead to new treatments for cancer patients while at the same time promoting efficiency and facilitating the prioritization of clinical research at the national level.

PI_NAMEs: CHIANG, ANNE C (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Advocate;American College of Radiology Imaging Network;Award;Biology;Cancer Hospital;Cancer Patient;cancer therapy;Caring;Chemicals;Clinical Cancer Center;clinical center;Clinical Oncology;Clinical Research;Clinical Trials;Clinical Trials Cooperative Group;Collaborations;Comprehensive Cancer Center;Connecticut;Cooperative Group Program;Detection;Diagnosis;Disease;drug development;Eastern Cooperative Oncology Group;Ensure;Epidermal Growth Factor Receptor;Faculty;Funding;Grant;Gynecologic Oncology;hospital care;Hospitals;Infrastructure;International;Laboratories;Lead;Leadership;Malignant Neoplasms;Medical Oncology;medical schools;member;Mentors;Mentorship;National Cancer Institute;next generation;Operations Research;patient population;performance site;Personnel Staffing;Phase;Physicians;pilot trial;Prevention approach;Program Development;programmed cell death protein 1;programs;Radiation Oncology;Randomized;Recording of previous events;Research;Research Personnel;Resistance;Resources;Rewards;Role;santin;Science;Scientist;Signal Transduction;Solid;Southwest Oncology Group;standard of care;success;Supervision;Support Groups;System;Time;Training;translational potential;Translational Research;Universities;Vision;War;Work;Yale Cancer Center

PROJECT_TITLE: Yale Cancer Center NCTN LAPS


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Defects in migration and consequent mispositioning of pyramidal neurons in the developing neocortex are associated with neurodevelopmental disorders (NDDs) of cognition and epilepsy; yet, the molecular mechanisms that govern the migration of such neurons remain poorly understood. This application proposes to define and characterize key molecular components necessary for proper neocortical pyramidal neuron migration and to elucidate how defects in this process contribute to common brain disorders. Knowledge gained from these studies is expected to lead to a better understanding of the signaling defects that underlie NDDs of cognition and epilepsy, and aid the development of new therapeutic strategies for these disorders. ! !

PI_NAMEs: VAN AELST, LINDA  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Animals;Applied Genetics;associated symptom;Axon;Behavior;Behavioral;behavioral response;Binding;Biochemical;Birth;Birth Place;Brain;Brain Diseases;Brain-Derived Neurotrophic Factor;Cell Physiology;Cognition Disorders;Cues;Data;Defect;Dendrites;Destinations;Development;Developmental Delay Disorders;Disease;Electrophysiology (science);Electroporation;Embryo;Embryonic Development;Epilepsy;Exhibits;experimental study;fiber cell;Genetic;genetic approach;Genetic Epistasis;Goals;hippocampal pyramidal neuron;Human;Impairment;in utero;in vivo;Individual;innovation;insight;Intellectual functioning disability;Knowledge;Label;Lead;Learning Disabilities;Link;Mediating;Membrane;Mental Retardation;Methods;migration;Molecular;Morphogenesis;Morphology;Mus;mutant;Mutation;Neocortex;neocortical;Neurodevelopmental Disorder;Neuroglia;Neurons;Neurotrophic Tyrosine Kinase Receptor Type 2;Newborn Infant;novel;novel therapeutic intervention;Pathogenesis;Pathway interactions;Patients;Phosphorylation;Play;Positioning Attribute;postmitotic;postnatal;Predisposition;Process;Proline-Rich Domain;Proteins;Radial;receptor;recruit;Regulation;rho;rho GTPase-activating protein;Role;Seizures;Sensory;Signal Transduction;social;Structure;Synapses;Syndrome;Techniques;Testing;tool;Tyrosine Phosphorylation

PROJECT_TITLE: Neurodevelopmental Disorder-Associated Rho Regulators in Neocortical Development

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Cancer;Cancer Genomics;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Immunotherapy;Infectious Diseases;Microbiome;Pediatric;Regenerative Medicine;Transplantation

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative The gut microbiome plays a critical role in shaping host innate and adaptive immune responses. We are investigating how the gut microbiome modulates the immune system in cancer and stem cell transplant patients. This project will train junior investigators on using patient-oriented research to improve the health of cancer and stem cell transplant patients.

PI_NAMEs: KOH, ANDREW  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Antitumor Response;Award;Bacterial Infections;bacterial resistance;Basic Science;Biological;cancer cell;cancer immunotherapy;Cancer Patient;career;career development;Centers for Disease Control and Prevention (U.S.);checkpoint therapy;Child;Childhood;Clinic;Clinical;Clinical Investigator;Clinical Services;Communicable Diseases;Development;Diagnosis;disease model;disease phenotype;Etiology;experience;Exposure to;Foundations;Funding;Future;Generations;Goals;graft vs host disease;Grant;gut colonization;gut microbiome;gut microbiota;Health;Hematology;Hematopoietic Stem Cell Transplantation;Immune checkpoint inhibitor;Immune response;Immune system;Immunocompromised Host;Immunology;immunoregulation;improved;in vitro Model;Industry;Innate Immune Response;insight;Institution;interest;Intestinal Graft Versus Host Disease;Investigator-Initiated Research;K-Series Research Career Programs;Knowledge;Laboratories;Lead;Leadership;Malignant Neoplasms;Medical center;Mentors;Mentorship;Methods;microbial;Microbial Antibiotic Resistance;Microbiology;microbiome;microbiome research;microbiome signature;Mid-Career Clinical Scientist Award (K24);mid-career faculty;Mycoses;National Institute of Allergy and Infectious Disease;next generation;novel;novel therapeutics;Oncologist;Oncology;pathogenic bacteria;pathogenic fungus;patient oriented;patient oriented research;Patient-Focused Outcomes;Patients;pediatric department;Phenotype;Physician Executives;Physicians;Play;Positioning Attribute;pre-clinical;prevent;Privatization;Productivity;programs;Research;research and development;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;Role;Scientist;Shapes;skills;Source;Specialist;Stem cell transplant;Structure;Supervision;Talents;Texas;Time;Training;Training Programs;translational approach;translational research program;translational scientist;Translations;Transplant Recipients;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Mentoring Patient Oriented Research in the Microbiome of Cancer and Stem Cell Transplant Patients

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Failure to identify bacterial and fungal infections rapidly places an enormous financial burden on the U.S. health system totaling billions annually with complications from minor events extending hospital stays to death from sepsis. We have developed a lipid-based MS method for bacterial and fungal identification that can be carried out in under an hour direct from specimen. Here, we will further develop this method for use in the study of complex biological fluids, including stool, urine, and blood bottles without culture. Specifically, we will improve the limit of detection in order to distinguish microbial load at or below 103 CFU/ml ! !

PI_NAMEs: ERNST, ROBERT K (contact);GOODLETT, DAVID ROBINSON

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: accurate diagnosis;Address;Animal Model;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;Bacterial Infections;Bacterial Proteins;Bar Codes;biodefense;Biological;Biological Assay;Blood;Cardiolipins;Cell Culture Techniques;Cells;Cessation of life;chemical fingerprinting;Chemicals;chemotherapy;Clinical;Clinical Microbiology;clinically relevant;Colistin;combat;Communicable Diseases;Complex;Computer software;cost;Data;Detection;detection limit;Development;Diagnostic;diagnostic platform;Escherichia coli;Event;Experimental Designs;Face;Failure;feature extraction;Feces;Financial Hardship;Funding;fungus;General Hospitals;global health;Glycerophospholipids;Glycolipids;Grant;Growth;Health care facility;Health system;Healthcare;Hour;improved;Individual;Infection;innovation;Intensive Care;Ions;Laboratories;Laboratory Research;Length of Stay;Libraries;Lipid A;Lipids;lipoteichoic acid;Liquid substance;Machine Learning;MALDI-TOF Mass Spectrometry;Mass Spectrum Analysis;Membrane;Membrane Lipids;Methodology;Methods;Microbe;microbial;microbial products;Minor;Modeling;Morbidity - disease rate;mortality;Mycoses;new technology;novel;novel diagnostics;novel therapeutics;Organism;pathogen;pathogenic fungus;Patients;Pattern;Peer Review;Phenotype;point of care;Predisposition;Process;Proteins;Protocols documentation;Publications;rapid diagnosis;resistant strain;Sampling;Sepsis;simulation;software development;Solid;Specimen;Speed;Sphingolipids;Sterols;stool sample;Structure;tandem mass spectrometry;Technology;Time;tool;Urinary tract infection;Urine;ward;Work;wound

PROJECT_TITLE: MS Diagnostic Bacterial Identification Library

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

PHR: Project Narrative Effective January 1, 2021, Medicare will open up enrollment in private managed care plans, known as Medicare Advantage plans, to all patients with kidney failure. This study will investigate the impact of the expansion of managed care on health outcomes and disparities among persons with kidney failure.

PI_NAMEs: TRIVEDI, AMAL N. (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: access disparities;Accountability;Address;Admission activity;Adopted;American;beneficiary;black patient;bundled payment;care outcomes;Caring;Cessation of life;Characteristics;Clinical;Communities;Complex;cost;County;Data;Death Rate;design;Diagnosis;Dialysis patients;Dialysis procedure;Disparity;End stage renal failure;Enrollment;Equity;ethnic minority;ethnic minority population;Evaluation;experimental study;Face;falls;Geography;Health;health care availability;health equity;Health Policy;Healthcare;Hemodialysis;Home;hospital readmission;Hospitalization;Impairment;improved;improved outcome;Incentives;Incidence;innovation;insight;Interview;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;living kidney donor;Low income;Managed Care;Managed Care Programs;Marketing;Medicare;Methods;Modeling;Morbidity - disease rate;mortality;neighborhood disadvantage;Neighborhoods;Nephrology;novel;Outcome;Patient-Focused Outcomes;Patients;payment;Peritoneal Dialysis;Persons;Policies;Policy Maker;Population;Population Intervention;Poverty;Privatization;programs;Provider;Quality of Care;Quality of life;Quasi-experiment;racial disparity;racial minority;racial minority population;Renal Replacement Therapy;Risk;Risk Factors;Role;Services;social;social health determinants;socioeconomics;Special needs plan;Testing;Time;Transplantation;United States Centers for Medicare and Medicaid Services;Variant;Waiting Lists

PROJECT_TITLE: Effects of Expanding Medicare Advantage Enrollment toPersons with End-stage Renal Disease

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Coordination of Innate and Adaptive Immunity in Intestinal Barrier Defense. This proposal will generate new insights into mechanisms by which IL-22-producing innate and adaptive immune cells are coordinated to act on newly defined subsets of intestinal epithelial cells to protect the intestinal barrier under threat by enteropathogenic bacteria. These studies hold promise to reveal new insights into specialization of immune cell subsets in intestinal host defense and mechanisms that control intestinal inflammation in inflammatory bowel disease and colorectal cancer.

PI_NAMEs: WEAVER, CASEY T (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: adaptive immunity;Anti-Bacterial Agents;anti-microbial peptide;Antigen Presentation;antimicrobial;Bacteria;base;Binding;CD4 Positive T Lymphocytes;Cell Communication;Cell Line;cell type;Cells;chemokine;Chronic;Citrobacter rodentium;Colon;colonic crypt;Colorectal Cancer;Complex;conditional knockout;cytokine;defined contribution;Disease;Distal;enteric pathogen;Enterocytes;enteropathogenic Escherichia coli;Epithelial Cells;epithelial stem cell;Epithelium;Escherichia coli;Escherichia coli EHEC;extracellular;Family;Genes;Geography;Gram-Negative Bacteria;Growth;gut inflammation;gut microbiome;Heterogeneity;Host Defense;human disease;IL10RB gene;Immune;Impairment;Infection;Infectious colitis;Inflammatory Bowel Diseases;insight;Interleukin-10;interleukin-22;interleukin-23;intestinal barrier;intestinal crypt;intestinal epithelium;Intestines;Invaded;Knockout Mice;Lamina Propria;Location;Lymphoid Cell;Lymphoid Follicle;lymphoid structures;Malignant - descriptor;Mediating;Modeling;Mucous Membrane;Mus;Natural Immunity;Natural regeneration;neutrophil;Neutrophil Infiltration;novel;pathogen;Pathogenicity;Pathway interactions;Phagocytes;Phase;Play;Population;Positioning Attribute;prevent;Production;protective effect;recruit;repaired;Reporter;Reporting;response;restraint;Role;senescence;Signal Transduction;Site;Source;STAT3 gene;Surface;T cell response;T-Lymphocyte;Testing;Tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-H(04)]


ORG_CITY: CINCINNATI

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative: Since its establishment in 2000, the Ohio Valley Node (OVN) has been one of the most productive of NIDA's Clinical Trials Network (CTN) nodes, both in leading and participating in multi-site trials. The OVN includes successful partnerships with four healthcare systems, two pharmacy networks, and six addiction specialty/ infectious disease programs spanning a seven-state region including some of the states most heavily impacted by opioid (Ohio, Kentucky, and West Virginia) and methamphetamine (Missouri, Kentucky, and North Dakota) use. Our overall goal is to utilize the wealth of experience and expertise gained over the past 19 years to conduct the research needed to address public health care crises, including the opioid use epidemic and the alarming increase in stimulant use.

PI_NAMEs: WINHUSEN, T JOHN (contact)

PROGRAM_OFFICER_NAME: BERTZ, JEREMIAH WILLIAM

PROJECT_TERMS: Accident and Emergency department;addiction;Address;adverse event risk;African American;Appalachian Region;Area;Artificial Intelligence;Behavior Therapy;behavioral health;Bioinformatics;Buprenorphine;Clinic;Clinical;clinical center;clinical practice;Clinical Treatment;clinical trial participant;Clinical Trials;Clinical Trials Network;Cocaine use disorder;Collaborations;Communicable Diseases;Communities;Conduct Clinical Trials;Cultural Diversity;Data;Data Set;Databases;design;driving force;Drug abuse;effectiveness trial;efficacy trial;Electronic Health Record;Electronics;Enrollment;Ensure;Epidemic;experience;FDA approved;Formulation;Funding;Geography;Goals;health care service organization;Health Personnel;Health Services;Healthcare;Healthcare Systems;Hospitals;implementation trial;Infrastructure;innovation;Institution;Intervention;Investigational Drugs;Kentucky;Leadership;medical specialties;meetings;member;Methamphetamine;Mission;Missouri;Multi-Institutional Clinical Trial;multi-site trial;National Institute of Drug Abuse;Native Americans;North Dakota;Ohio;Opioid;opioid use;opioid use disorder;Participant;Patients;Performance;Perinatal;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;point of care;practice setting;Pregnant Women;prescription monitoring program;Primary Care;Productivity;programs;prospective;Public Health;racial diversity;Randomized;Recording of previous events;recruit;Research;Research Personnel;research study;retention rate;Serine;Services;Site;South American;statistics;stimulant use;stimulant use disorder;substance misuse;substance use;Substance Use Disorder;support tools;System;technology intervention;Testing;treatment program;trend;validation studies;West Virginia;Work

PROJECT_TITLE: The Ohio Valley Node of the Clinical Trials Network


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative The sensitivity and availability of omic technologies have allowed for the development of treatments that target specific disease subtypes, most notably in cancer treatment, and thus opened up opportunities for the development of precision/personalized medicine strategies for optimizing treatments for individual patients. Thus, new genomic science educational initiatives need to be continually updated to educate the clinical and translational workforce on how to effectively interpret and apply the findings from genomics studies. The overall goal of the Clinical Research Education in Genome Science program is to increase the methodologic ingenuity of students, postdoctoral fellows, and faculty from academic institutions nationwide through a solid foundation in genomics science to answer complex, clinical research questions and improve patient care.

PI_NAMEs: BENN, EMMA KATHERINE TARA (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Acceleration;Area;Biomedical Research;cancer therapy;Cells;Clinical;clinical care;Clinical Data;Clinical Research;Communities;Competence;Complex;computerized tools;Critical Thinking;Data;Data Analyses;data management;Development;disease phenotype;disorder subtype;doctoral student;Education;education research;Educational Curriculum;Educational process of instructing;efficacy evaluation;Ensure;Exercise;Faculty;Foundations;Future;Gene Expression;Genetic;genetic analysis;genome sciences;genomic data;Genomic medicine;Genomics;Goals;grasp;Health;health disparity;Hour;Human;Hybrids;improved;individual patient;innovation;Institution;Knowledge;lectures;Logistics;Machine Learning;machine learning method;Medical;Methodology;Methods;minority investigator;Mission;National Human Genome Research Institute;operation;Outcome;Participant;Patient Care;Patients;personalized medicine;Persons;Phase;Phenotype;Play;Postdoctoral Fellow;precision medicine;Problem Solving;programs;Proteomics;Provider;recruit;Recruitment Activity;Reproducibility;Research;Research Methodology;Research Personnel;Resources;response;Role;science education;Single Nucleotide Polymorphism;Solid;statistical and machine learning;Statistical Methods;Students;success;Technology;theories;therapy development;Tissues;tool;Training;transcriptomics;Translational Research;treatment optimization;Treatment outcome;Underrepresented Minority;Underserved Population;Update;virtual

PROJECT_TITLE: Clinical Research Education in Genome Science (CREiGS)

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Poor medication adherence in heart failure can lead to poor health, but many clinicians are unable to determine who would benefit from interventions to address adherence. We will build machine learning models to identify patients at risk of not taking their medicines using an approach that minimizes potential biases. Electronic health record data will be used in these models, allowing them to be incorporated into interventions to improve medication adherence and reduce the disease burden of heart failure.

PI_NAMEs: ADHIKARI, SAMRACHANA ;BLECKER, SAUL B. (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Adherence;algorithm development;Algorithms;Big Data;burden of illness;Calibration;Cessation of life;Clinical;clinical care;Clinical Data;Communities;Complex;contextual factors;Data;Data Element;Development;Economic Factors;electronic health data;Electronic Health Record;Ensure;evidence base;flexibility;Goals;Health;health data;Health system;Healthcare Systems;Heart failure;high risk;hospital readmission;hospitalization rates;improved;improved outcome;Individual;innovation;Intervention;Link;Location;Machine Learning;machine learning algorithm;machine learning model;Malignant Neoplasms;Measurement;medication compliance;medication nonadherence;Medicine;model generalizability;Modeling;mortality;Neighborhoods;novel;Outcome;patient population;patient subsets;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Pharmacy facility;point of care;population based;Population Heterogeneity;prediction algorithm;predictive modeling;predictive tools;Process;Provider;racial population;Risk;Risk Factors;social determinants;Social Environment;social factors;social health determinants;socioeconomics;supervised learning;System;Techniques;Time;tool;Update;Urban Health;Validation;Work

PROJECT_TITLE: Generalizable prediction of medication adherence in heart failure

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Clinical Research;Genetics;Immunotherapy;Patient Safety;Prevention

PHR: Project Narrative This study will investigate the real-world epidemiology, downstream implications, and risk factors for the development of cutaneous immune-related adverse events (cirAE) in the setting of immune checkpoint inhibitor therapy using cross-validated multi-institutional and population-level data. The study will additionally identify germline genetic associations for cirAE onset, particularly in the Human Leukocyte Antigen region and combine these findings with the above clinical risk factors to generate an integrated risk prediction model of cirAEs. The results of this study will serve as the foundation for establishing rigorous definitional standards of cirAEs and provide new pathogenic insights into their development.

PI_NAMEs: SEMENOV, YEVGENIY R (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Adverse event;Adverse reactions;Alleles;Antigenic Variation;antitumor effect;Autoimmune Diseases;Autoimmunity;Big Data;cancer therapy;Case Study;checkpoint therapy;Clinical;Clinical Data;clinical decision support;clinical development;clinical risk;Clinical Trials;clinically relevant;Cutaneous;Dana-Farber Cancer Institute;Data;Dermatologic;Development;Disease susceptibility;Eligibility Determination;Epidemiology;Etiology;Event;experience;follow-up;Foundations;Funding;Genetic;genetic association;Genetic Risk;genetic risk factor;genetic variant;Genomics;Genotype;Germ Lines;high risk;HLA Antigens;Immune checkpoint inhibitor;immune-related adverse events;Immunosuppression;Immunotherapy;Impairment;Incidence;Individual;insight;Institution;Insulin-Dependent Diabetes Mellitus;Interruption;large scale data;Life;Literature;Malignant Neoplasms;Modeling;Morbidity - disease rate;Morphology;mortality;Observational Study;Outcome;Pancreatitis;Pathogenesis;Pathogenicity;patient oriented;patient population;Patients;Phenotype;polygenic risk score;Population;predictive modeling;Predisposition;Quality of life;Reporting;Research;Research Personnel;Risk Factors;Risk Marker;risk prediction model;risk stratification;risk variant;Severities;Skin Carcinoma;skin disorder;standard of care;Time;Tissue Sample;TNFRSF10A gene;tool;Toxic effect;Validation;Vulnerable Populations

PROJECT_TITLE: Predictive modeling of cutaneous immune checkpoint inhibitor toxicities

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative: This proposal is designed to uncover the role of neutrophils and the extracellular adenosine producing enzyme CD73 in host susceptibility to secondary pneumococcal pneumonia following influenza virus infection. This will allow identification of novel targets to boost host resistance against these serious pathogens.

PI_NAMEs: BOU GHANEM, ELSA  (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Accounting;Adenosine;Adoptive Transfer;Age;age effect;age related decline;aged;Aging;Animal Model;Anti-Bacterial Agents;Antibacterial Response;antimicrobial;Bacteria;Bacterial Infections;Bacterial Pneumonia;cell injury;Cells;Cessation of life;Clinical;co-infection;combat;design;Disease;Drug Targeting;Economic Burden;Elderly;Environment;Enzymes;Epithelium;Etiology;Evolution;extracellular;Goals;Healthcare;Host resistance;Human;human disease;human old age (65+);Immune;Immune response;Impairment;improved;Individual;Infection;Inflammation;Influenza;Influenza A virus;influenza infection;innovation;Knockout Mice;Lower respiratory tract structure;Lung;Lung Diseases;lung injury;Mediating;Microbial Biofilms;Modeling;mouse model;Mus;Nasal cavity;Nasopharynx;neutrophil;novel;novel strategies;novel therapeutics;old mice;Outcome;pandemic disease;pathogen;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Physiological;Play;Pneumococcal Infections;Pneumococcal Pneumonia;Predisposition;Production;receptor;recruit;Resistance;Resistance to infection;Respiratory Tract Infections;response;Risk;Role;Secondary to;Signal Transduction;Streptococcus pneumoniae;synergism;Testing;Time;time use;Tissues;Virus Diseases;Vulnerable Populations;Work

PROJECT_TITLE: The role of PMNs and CD73 in host-resistance against S. pneumoniae / influenza A virus co-infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Contraception/Reproduction;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT SUMMARY Gonorrhea is a major public health problem globally. This proposal seeks to further develop analogs of sialic acid that target a key gonococcal virulence mechanism. The goal is to develop a safe and effective drug that can be administered to women through intravaginal rings to prevent gonococcal infections and curb the spread of multidrug-resistant gonorrhea.

PI_NAMEs: MOSS, JOHN A;RAM, SANJAY  (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: Acids;Affect;analog;Antibiotic Resistance;Antibiotics;Antibodies;Antimicrobial Cationic Peptides;Azithromycin;Bacteria;Bacterial Vaginosis;Binding;Biological Assay;cathelicidin;Ceftriaxone;cervicovaginal;chronic pelvic pain;Clinical;Collaborations;combat;Communities;Complement;Cytidine Monophosphate N-Acetylneuraminic Acid;Data;Development;Disease;Drug Kinetics;drug-resistant gonorrhea;dysbiosis;Ectopic Pregnancy;Ensure;Family;Formulation;Genitalia;Geographic Locations;Geography;Goals;Gonorrhea;Growth;Histopathology;HIV;Human;Hydrolase;Immune Evasion;Immunity;In Vitro;in vivo;Incidence;Infection;infection burden;Infertility;Inflammatory Response;Lead;lead candidate;Leg;lipooligosaccharide;Liquid substance;Mediating;member;method development;Methods;Microbial Biofilms;microorganism;Multi-Drug Resistance;Mus;Neisseria gonorrhoeae;Neuraminidase;novel therapeutics;pathogen;Pharmaceutical Economics;Pharmaceutical Preparations;Phase I Clinical Trials;Play;Polysaccharides;pre-Investigational New Drug meeting;Predisposition;prevent;Process;product development;Production;Productivity;Public Health;public health priorities;receptor;Recommendation;Reporting;reproductive tract;Resistance;Risk;Safety;scale up;sheep model;sialic acid binding Ig-like lectin;Sialic Acids;sialylation;Sialyltransferases;Specificity;Surface;Testing;transmission process;trend;United States;Vagina;vaginal fluid;vaginal microbiome;vaginal microbiota;Vaginal Ring;Virulence;Woman;Work

PROJECT_TITLE: Sialic acid analogs against multidrug-resistant gonorrhea


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE In Kenya, like many other resource-limited settings, neonatal mortality remains unacceptably high. Community health volunteers (CHVs) are a large cadre of lay health workers whose role includes conducting home visits to pregnant and postpartum women to promote neonatal health. This study will develop an interactive SMS text messaging intervention that remotely connects mothers with CHVs, and evaluate the intervention’s effect on clinical outcomes (neonatal mortality, facility visits and essential newborn care), service outcomes (CHV and supervisor workflow), and implementation outcomes (acceptability, uptake and fidelity of implementation), when implemented as part of routine CHV workflow in Western Kenya.

PI_NAMEs: RONEN, KESHET  (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Access to Information;Address;Adopted;Adoption;Area;arm;Behavioral;Birth;Breast Feeding;care seeking;Caregivers;Caring;Cessation of life;Child;Client;Clinic;Clinic Visits;Clinical;Cluster randomized trial;cohort;Communication;Communities;Community Health;community intervention;Consultations;County;County Government;Data;Data Reporting;design;Deterioration;digital;digital communication;Education;Effectiveness;Enrollment;Federal Government;Friends;Goals;Health;health care delivery;Health Personnel;high risk;Home;Home visitation;human centered design;implementation fidelity;implementation outcomes;improved;Infant;Infant Care;Infrastructure;innovation;Intervention;intervention effect;Kenya;Knowledge;Late pregnancy;Life;Maternal Health;Medical;Metadata;mortality;Mothers;Motivation;Names;Neonatal;neonatal health;Neonatal Mortality;neonatal outcome;neonatal period;neonate;Nurses;Outcome;Participant;Patient Self-Report;Population Density;postpartum care;Postpartum Period;Postpartum Women;Pregnant Women;prevent;preventable death;Preventive care;Preventive treatment;Primary Health Care;Public Health;Questionnaires;Randomized;Recommendation;remote intervention;Resource-limited setting;response;Risk;Role;satisfaction;service delivery;Services;skills;Social support;standard of care;Standardization;success;text messaging intervention;theories;Time;Triage;uptake;Visit;volunteer;Woman

PROJECT_TITLE: CHV-NEO: Community-based digital communication to support neonatal health

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


NIH_SPENDING_CATS: Clinical Research;Eczema / Atopic Dermatitis;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_DEPT: DERMATOLOGY

PHR: Project Narrative: Atopic dermatitis (AD) presents a high unmet need for better therapies in different ethnic (African American, Asians) and severity subtypes. This study will set the stage for a personalized medicine approach to improve treatments for patients of different ethnic backgrounds and disease severity.

PI_NAMEs: GUTTMAN, EMMA  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: 18 year old;Adult;Affect;Africa;African;African American;American;Asia;Asian;Asian Americans;Asian population;Atopic Dermatitis;attenuation;Biological Markers;Biopsy;Blood;Blood specimen;Body Surface;Body Surface Area;Characteristics;chemokine;China;Clinical;cytokine;Cytokine Activation;Data;Defect;Development;Disease;Disease Progression;DNA;Enrollment;Epithelial Cell Aggregation and Separation;ethnic difference;Ethnic Origin;Ethnic Population;European;exome sequencing;Flow Cytometry;Gene Expression;Genetic;genetic analysis;Genetic Polymorphism;Genetic Risk;Genomics;Healthcare;Hyperplasia;IgE;Immune;immune activation;Immune Targeting;Immunohistochemistry;Immunologic Markers;improved;individualized medicine;Inflammation;innovation;Interleukin-13;Interleukin-4;Investigation;Japan;keratinocyte;Korea;Location;Maps;microbiome;Modality;Modeling;Molecular;molecular phenotype;new therapeutic target;novel therapeutics;Pathogenesis;Pathway interactions;Patients;personalized medicine;Phenotype;Population;Prevalence;Pruritus;Psoriasis;Punch Biopsy;Quality of life;Quantitative Reverse Transcriptase PCR;Reporting;Resistance;response;risk variant;RNA;Serum;Severities;Severity of illness;Skin;skin barrier;skin lesion;Sleep Deprivation;Sleep disturbances;Subgroup;Surface;Swab;Systemic disease;systemic inflammatory response;Systems Biology;T-Cell Activation;T-Lymphocyte Subsets;Taiwan;Testing;Therapeutic;Topical agent;transcriptome sequencing;Widespread Disease

PROJECT_TITLE: Developing a Molecular Map of Atopic Dermatitis Across Ethnicity and Severity Subtypes.


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: CHARLESTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: Project Narrative This application will develop robust proteomic workflows to use glycoprotein-targeted affinity capture reagents for characterization of tumor-associated glycoproteins in tissue, cells and biofluids. The affinity reagents specifically target sialic acid tumor antigens known to be involved in cancer development and metastasis. The overall goal of this proposal is to develop new tools and methodologies to improve the isolation and sequencing of tumor localized glycopeptides from readily available clinical formalin-fixed tissues and other clinical samples.

PI_NAMEs: DRAKE, RICHARD R. (contact)

PROGRAM_OFFICER_NAME: MAZURCHUK, RICHARD V

PROJECT_TERMS: Affinity;Alkynes;amidation;Antibodies;Antigens;Area;Azides;biobank;Biological Markers;CA-19-9 Antigen;cancer biomarkers;Cancer cell line;Cancer Diagnostics;Cancer Patient;cancer prevention;Carbohydrates;carcinogenesis;Cell Communication;Cell Line;cell stroma;Cell surface;Cell-Cell Adhesion;Cells;chemical reaction;Chemistry;Clinical;clinically relevant;Complex;Detection;Development;Drug or chemical Tissue Distribution;Environment;Evaluation;extracellular;Extracellular Matrix;FDA approved;Formalin;Fucose;Glycocalyx;Glycopeptides;Glycoprotein Degradation Pathway;Glycoproteins;glycosylation;Goals;Histopathology;Human;Human Resources;human tissue;Image;imaging approach;Immune;improved;Individual;interest;Isomerism;Knowledge;Laboratories;Ligand Binding;Link;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;mass spectrometric imaging;Mediating;Methodology;Microscopy;Neoplasm Metastasis;neoplastic cell;novel;novel diagnostics;pancreatic cancer cells;Patients;Peptide Hydrolases;Plasma;Polysaccharides;portability;Post-Translational Protein Processing;Process;Prognosis;Prostatic;Protein Glycosylation;Proteins;Proteoglycan;Proteomics;Reagent;Receptor Signaling;Reproducibility;Research;Resolution;Sampling;Serum;Sialic Acids;sialyl Lewis a;sialyl Lewis x;sialylation;Site;Solid Neoplasm;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Surface;Therapeutic;tissue fixing;Tissue imaging;Tissues;tool;tumor;Tumor Antigens;Tumor Biology;Tumor Markers;tumor microenvironment;Tumor Tissue;Tumor-Derived;Urine

PROJECT_TITLE: Targeted Isolation and Identification of Sialylated Glycoproteins in Cancer Tissues, Cells and Biofluids


NIH_SPENDING_CATS: Cardiovascular;Congenital Structural Anomalies;Heart Disease;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Mutations in tafazzin (Taz, also known as G4.5) cause Barth syndrome (BTHS, MIM 302060), a life-threatening disorder disrupting metabolism of the mitochondrial-specific phospholipid cardiolipin (CL). However, little is known as to the detailed molecular mechanisms by which Taz deficiency and consequent CL abnormalities lead to the progression of cardiomyopathy, and there is no curative therapy for BTHS. Proposed studies are aimed to investigate detailed molecular mechanisms by which Taz deficiency causes cardiomyopathy, and to assess therapeutic effects of linoleic acid (LA) supplementation, and/or treatment with the mitochondrial PLA2 inhibitor bromoenol lactone (BEL), by utilizing a Taz cardiomyocyte-specific knockout (cKO) mouse model.

PI_NAMEs: FANG, XI  (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: 3-Methylglutaconic aciduria type 2;Acylation;Acyltransferase;Age Months;Age Years;Allium cepa;Anabolism;Appearance;Architecture;ATP Synthesis Pathway;Biochemical;Biopsy;Cardiac;Cardiac Myocytes;Cardiolipins;Cardiomyopathies;Cells;Characteristics;Clinical;Complex;Crista ampullaris;Cultured Cells;curative treatments;Data;deacylation;Defect;Dilated Cardiomyopathy;Disease;Exhibits;Family;Fatty Acids;Functional disorder;Generations;Glycerol;Growth;Heart;Heart failure;heart function;Histologic;Homeostasis;human old age (65+);in vivo;Infant Mortality;Inner mitochondrial membrane;Knock-out;Knockout Mice;Lactones;Lead;Life;Link;Linoleic Acids;lipid disorder;LoxP-flanked allele;Lysophospholipids;malformation;Mediating;Metabolism;Mitochondria;mitochondrial cardiomyopathies;Mitochondrial Membrane Protein;mitochondrial metabolism;Modeling;Molecular;Molecular Analysis;molecular pathology;Morphology;mouse model;Mus;Mutation;Myocardial dysfunction;Myopathy;Neutropenia;Pathogenicity;Pathway interactions;Patients;Phenotype;Phospholipase A2;phospholipase A2 inhibitor;Phospholipids;Physiological;preservation;Process;prohibitin;protein complex;Respiration;Role;Shapes;Site;skeletal;Supplementation;System;targeted treatment;Therapeutic;therapeutic development;Therapeutic Effect;Therapeutic Intervention;Transacylase;transacylation;Transplant Recipients

PROJECT_TITLE: Molecular mechanisms and treatment of cardiomyopathy in Barth Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MIM-R(01)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Drug Abuse (NIDA only);Mental Health;Natural Products;Neurosciences;Pediatric;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: BLOOMINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PUBLIC HEALTH RELEVANCE Cannabis is widely used recreationally by adolescents and young adults, thus exposing the brain to delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) as it goes through its final development. Our studies will examine the impact of THC, CBD, and THC + CBD on the developing adolescent brain to determine their individual effects and potential interactions. We will also evaluate potential therapeutic strategies to treat the long-lasting behavioral and cognitive deficits that emerge in adults after adolescent cannabis use.

PI_NAMEs: LU, HUI-CHEN  (contact);MACKIE, KENNETH

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: addiction;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Adverse effects;age related;Anatomy;attenuation;Behavior;Behavioral;behavioral impairment;Brain;Brain region;Cannabidiol;Cannabis;Chronic;CNR1 gene;Cognitive;Cognitive deficits;cognitive function;Data;Defect;designer receptors exclusively activated by designer drugs;Development;Disease;Dose;effective therapy;Electrophysiology (science);emerging adult;Endocannabinoids;executive function;experimental study;Female;Functional Imaging;Genetic;Goals;Human;imaging study;Impairment;Individual;insight;Interleukin-6;Intoxication;Life;Link;male;marijuana use;Medial;Mediating;Memory impairment;Mental disorders;Microglia;Modeling;Molecular;Mood Disorders;Mus;neural circuit;neuroinflammation;novel;Outcome;Pathway interactions;pharmacologic;phytocannabinoid;Play;Predisposition;Prefrontal Cortex;prevent;Process;Psychotic Disorders;Public Health;public health relevance;Recreation;Research;Risk;Rodent;Role;sex;Short-Term Memory;Synapses;synaptic pruning;Testing;Tetrahydrocannabinol;Thalamic structure;THC exposure;Therapeutic;Treatment Efficacy;vulnerable adolescent;young adult

PROJECT_TITLE: Mechanisms and treatment of adolescent phytocannabinoid impairment of prefrontal cortex function


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Rhinovirus (RV) is an important pathogen that in addition to causing the common cold, cause severe manifestations of lung disease including asthma and COPD exacerbations. The numerous RV species are not equally virulent in their capacity to induce asthma exacerbations. This project will analyze STING, an RV host factor for the more virulent species, by deciphering its mechanism, and its role in immune signaling during infection.

PI_NAMEs: SWANSON, KAREN V (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Alleles;Asthma;asthma exacerbation;Binding;Binding Proteins;Cells;Chronic Obstructive Pulmonary Disease;Classification;combat;Common Cold;Complex;cytokine;Cytoplasm;Data;Dependence;Disease;DNA;DNA Viruses;experimental study;Family Picornaviridae;Frequencies;Future;Gene Expression;gene function;gene interaction;genetic variant;Genome;Goals;Hospitals;Human;Human Activities;human pathogen;Immune;Immune signaling;Infection;Inflammatory Response;Innate Immune Response;innate immune sensing;insight;Integration Host Factors;Interferon Type I;Interferons;Label;Lower Respiratory Tract Infection;Lung Diseases;Maps;Mediating;Mus;Mutation;NF-kappa B;Nonstructural Protein;pathogen;Pathogenesis;Phylogenetic Analysis;Play;Population;Proteins;Proteomics;Research;respiratory;response;Rhinovirus;Rhinovirus infection;RNA;RNA Viruses;Role;Signal Transduction;Signaling Protein;Single Nucleotide Polymorphism;Stimulator of Interferon Genes;superresolution microscopy;Variant;viral fitness;Viral Proteins;Virulence;Virulent;Virus;Visit;Work

PROJECT_TITLE: Host Factors for Rhinovirus

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Cancer;Genetics;Skin Cancer

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: We previously demonstrated that melanoma cells depend upon adipocytes in the subcutaneous tissues of the skin. In this proposal, we aim to elucidate the mechanisms by which lipids from those adipocytes get released, and how they alter the gene expression programs of the melanoma cell..

PI_NAMEs: OVERHOLTZER, MICHAEL H. (contact);WHITE, RICHARD MARK

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Acceleration;Acetyl Coenzyme A;Adipocytes;Affect;Award;Catecholamines;cell behavior;Cell Culture Techniques;Cell Line;Cell secretion;Cells;Coupled;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Data;Dermal;DNA Sequence Alteration;Embryo;Enzymes;Epigenetic Process;Event;Extracellular Space;fatty acid-transport protein;Fatty Acids;Funding;Gene Expression;Genes;Genetic;Genetic Transcription;Glucose;Goals;Growth;Histone Acetylation;histone acetyltransferase;Human;human disease;human tissue;In Vitro;in vivo;Interruption;Invaded;Knock-out;Knockout Mice;Link;Lipids;Lipolysis;long chain fatty acid;Malignant - descriptor;Malignant Neoplasms;MAP Kinase Gene;Mediating;Medium chain fatty acid;Melanins;melanocyte;Melanoma;Melanoma Cell;Metabolism;Modeling;mouse model;Nature;neoplastic cell;Neural Crest;non-genetic;Oncogenic;overexpression;oxidation;pharmacologic;Pigments;Production;programs;Proliferating;promoter;Proteins;Role;Science;Signal Induction;Signal Transduction;Skin;Skin Tissue;Somatic Mutation;Source;subcutaneous;Subcutaneous Tissue;Testing;therapeutic target;Tissue Model;Tissues;transgene expression;Transgenic Organisms;Translations;tumor;uptake;Validation;Work;Zebrafish

PROJECT_TITLE: Lipid programs in melanocyte transformation

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE: Cardiotoxicity in the form of deadly abnormal rhythms is one of the most common and dangerous risks for drugs in development. There is an urgent need for new approaches to accurately screen and predict the effects of drugs on cardiac rhythms. Our team proposes a new computer-based model framework to predict drug effects from the level of the atom to the cardiac rhythm.

PI_NAMEs: CLANCY, COLLEEN E (contact);SANTANA, LUIS F;VOROBYOV, IGOR

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Action Potentials;Adrenergic Receptor;Agreement;Anti-Arrhythmia Agents;Arrhythmia;Award;Back;Behavior;beta-adrenergic receptor;Binding;Cardiac;Cardiotoxicity;Categories;Cells;Chemical Structure;Chemicals;Chemistry;Clinical Data;Complex;computational pipelines;Computer Models;Dangerousness;Data;deep learning;design;Development;Discipline;Disease;Disparate;Dissection;drug classification;Drug Combinations;Drug Design;drug development;drug discovery;Drug Interactions;Drug Kinetics;drug mechanism;Drug Screening;drug structure;Drug toxicity;Electrocardiogram;Experimental Models;Exposure to;Goals;Heart;heart rhythm;Human;improved;in silico;innovation;insight;Investigation;Ion Channel;Kinetics;Machine Learning;Maps;Medicine;Methodology;Modeling;Molecular;Molecular Conformation;Movement;multi-scale modeling;novel;novel strategies;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Physicians;Physiological;Poison;Potassium Channel;predictive modeling;Process;Property;protein function;Research Personnel;Risk;Safety;scale up;screening;Screening procedure;side effect;Signal Transduction;simulation;Structure;Structure-Activity Relationship;System;Therapeutic;Time;Tissues;Validation;virtual;voltage;Work;Writing

PROJECT_TITLE: In silico safety pharmacology

STUDY_SECTION: ESTA

STUDY_SECTION_NAME: Electrical Signaling, Ion Transport, and Arrhythmias Study Section[ESTA]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_NAME: MONELL CHEMICAL SENSES CENTER

ORG_STATE: PA

PHR: PROJECT NARRATIVE Taste bud integrity requires innervation from gustatory neurons, but how neurons regulate taste bud homeostasis is not well established. We will use genetically engineered mice, a gustatory nerve transection model, adenovirus encoding recombinant proteins, and a novel three-dimensional taste organoid culture model to determine the role of the gustatory neuron-produced factor R-spondin-2 in regulating adult taste stem cell activity. The results from this project may help develop novel treatment strategies for individuals who experience taste impairments such as cancer patients receiving chemotherapy or elderly with reduced taste sensibility.

PI_NAMEs: JIANG, PEIHUA  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: 3-Dimensional;Ablation;Adenoviruses;Adult;Ageusia;Altered Taste;appetite loss;Behavioral;Binding;Cancer Patient;Cell Count;Cell Differentiation process;Cells;chemotherapy;Clinical;Data;Denervation;Distant;Elderly;Epithelial Cells;Epithelium;experience;gain of function;Ganglia;Generations;Genetic;genetic approach;Genetic Engineering;Genetically Engineered Mouse;Glossopharyngeal nerve structure;Homeostasis;Homologous Gene;Immunohistochemistry;Impairment;improved;In Situ Hybridization;In Vitro;in vivo;Individual;intravenous injection;Knockout Mice;LGR5 gene;Life;Ligands;Ligase;loss of function;LoxP-flanked allele;Maintenance;Malnutrition;Modeling;Molecular;Mus;mutant;Natural regeneration;Nerve;nerve supply;nerve transection;Neurons;novel;Organ;Organoids;Patients;Perinatal mortality demographics;Pharmaceutical Preparations;Phenotype;Property;protein purification;Quality of life;Radiation therapy;receptor;Recombinant Proteins;Recombinants;Recovery;Regulation;reinnervation;Research;Role;self-renewal;senescence;stem cell differentiation;stem cell expansion;stem cell proliferation;stem cell self renewal;stem cells;System;Taste Bud Cell;Taste Buds;Taste Perception;Testing;Tissues;Tongue;treatment strategy;ubiquitin-protein ligase

PROJECT_TITLE: Neuronal regulation of adult taste stem cells

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Patient Safety

PHR: PROJECT SUMMARY UNC Lineberger Comprehensive Cancer Center seeks to continue to serve as a Lead Academic Participating Site for the National Clinical Trials Network (NCTN). We have a remarkable track record of clinical research engagement and leadership, including multiple faculty members currently providing scientific leadership at the NCI and NCTN, a longstanding and exceptional commitment to and success in translational research in national trials, and a well-organized clinical trials unit to support participation in NCTN trials. Our mission is to design and perform practice-changing clinical research to benefit cancer patients of North Carolina.

PI_NAMEs: CAREY, LISA A (contact);MILOWSKY, MATTHEW I

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Applied Research;Award;Cancer Center;Cancer Patient;cancer therapy;cancer type;Caring;Center for Translational Science Activities;Clinical;clinical care;Clinical Research;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;Comprehensive Cancer Center;Dedications;design;Development;DNA;Extramural Activities;Faculty;feasibility trial;Fostering;Funding;Genome;Goals;Grant;Health;improved;improved outcome;Institution;Investigational Therapies;Investments;Lead;Leadership;Malignant Neoplasms;Medical;member;Mission;multidisciplinary;National Clinical Trials Network;next generation;North Carolina;operation;Operative Surgical Procedures;Persons;programs;Proteomics;Radiation;Research;RNA;Science;Site;State Hospitals;success;Technology;Testing;translational engagement;Translational Research;translational research program;UNC Lineberger Comprehensive Cancer Center;Universities

PROJECT_TITLE: UNC Lead Academic Participating Site


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Data Science;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Methamphetamine;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Primary Health Care;Rural Health;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_NAME: HENNEPIN HEALTHCARE RESEARCH INSTITUTE

ORG_STATE: MN

PHR: Improving substance use disorder treatment outcomes will require a broad range of research approaches. The NorthStar Node of the NIDA Clinical Trials Network (CTN) brings together diverse communities of patients, care models, and investigators with the ability to test a wide spectrum of interventions. Our network of implementation scientists and technology transfer experts are able to bring CTN discovery into practice.

PI_NAMEs: BART, GAVIN  (contact)

PROJECT_TERMS: Acceleration;accountable care organization;addiction;Address;adolescent health;Adoption;Algorithms;American;American Indian Population;Artificial Intelligence;Big Data;Cannabis;Cardiovascular Diseases;career;Caring;Childhood;Chronic;Chronic Disease;Clinic;Clinical;clinical practice;Clinical Research;Clinical Sciences;Clinical Treatment;Clinical Trials Network;cognitive training;collaborative care;Communities;community based participatory research;community engagement;community partners;comorbidity;Comparative Effectiveness Research;Counseling;County;Criminal Justice;Data Science;Development;Diagnosis;Disease Outcome;Dose;Drug abuse;Drug Kinetics;Drug user;Electronic Health Record;Ensure;evidence base;Federally Qualified Health Center;Fellowship Program;Guidelines;Health;health care delivery;health care service utilization;Health Personnel;Health Services Research;Health system;Healthcare;HIV;Homelessness;Housing;Human Resources;illicit drug use;implementation science;improved;Infrastructure;innovation;Institution;Integrated Health Care Systems;Intervention;Iowa;Learning;Machine Learning;machine learning algorithm;Major Depressive Disorder;Medical;medical specialties;Medicine;Mental disorders;Mentored Clinical Scientist Development Program;Mentors;Methamphetamine;Methamphetamine use disorder;Midwestern United States;Minnesota;Mission;Modeling;Multi-Institutional Clinical Trial;National Institute of Drug Abuse;Natural Language Processing;Neurosciences;North Dakota;novel therapeutic intervention;novel therapeutics;Opioid;Outcome;Patient-Focused Outcomes;Patients;personalized medicine;Persons;Pharmaceutical Preparations;Policies;Population;Population Heterogeneity;Positioning Attribute;pragmatic implementation;pragmatic trial;precision medicine;predictive modeling;primary care clinic;Protocols documentation;Psychiatry;Public Health Informatics;Randomized, Controlled Trials;Recovery;Research;research and development;Research Personnel;Rural;rural area;safety net;Scientist;screening;Site;Social Work;South Dakota;special interest group;Student Health Services;substance use;Substance Use Disorder;Technology Transfer;Testing;Training;Training Programs;transcranial direct current stimulation;Translating;Translational Research;Translations;Treatment outcome;treatment program;Underrepresented Minority;Universities;university student;urban area;urban Native American;Viral hepatitis;Wisconsin;Workforce Development;working group

PROJECT_TITLE: NorthStar Node of the Clinical Trials Network