NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pregnancy;Prevention;Serious Mental Illness;Sleep Research;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE FROM PARENT GRANT This research will provide definitive evidence about whether treating prenatal insomnia with digital cognitive behavior therapy for insomnia prevents depression during the perinatal period (i.e., pregnancy and the postpartum period). Currently, there are few intervention options for preventing perinatal depression, none focus on women with prenatal insomnia, and the accessibility of existing interventions is limited. Several attributes of our approach will facilitate its broad dissemination, including focusing on the low stigma target of insomnia and using a scalable intervention, with significant public health impact for reducing the burden of perinatal depression for mothers, children, families, and society.

PI_NAMEs: FELDER, JENNIFER NICOLE (contact)

PROGRAM_OFFICER_NAME: CHU, SERENA PO-LAN

PROJECT_TERMS: Address;animation;antepartum depression;Arousal;Belief;Blinded;Child;Child Rearing;Childbirth;Clinical Trials Design;clinically relevant;Cognitive;Cognitive Therapy;comparison group;Complication;confirmatory trial;Data;depression prevention;depressive symptoms;design;digital;Education;Educational Intervention;efficacy evaluation;efficacy testing;emotion regulation;Enrollment;experience;Family;flexibility;follow-up;Frequencies;Health Expenditures;Impairment;improved;Incidence;interest;Intervention;Knowledge;Major Depressive Disorder;Mediating;Mediator;Medicaid services;Mental Depression;Mothers;Outcome;parent grant;Participant;Perinatal;perinatal depressive symptom;perinatal period;peripartum depression;Population;Postpartum Depression;Postpartum Period;preference;Pregnancy;Pregnant Women;prenatal;prenatal experience;prevent;Prevention;preventive intervention;primary outcome;productivity loss;programs;Public Health;Randomized;Randomized, Controlled Trials;Recording of previous events;Research;Research Personnel;Research Project Grants;Risk Factors;Schedule;Severities;Sleep;sleep health;Sleeplessness;social stigma;societal costs;Societies;standard care;suicidal risk;symptomatic improvement;Symptoms;Testing;Therapeutic;Therapeutic Intervention;Thinking;Training;Travel;Wait Time;web site;welfare;Woman

PROJECT_TITLE: Efficacy of digital cognitive behavior therapy for insomnia for the prevention of perinatal depression - div supp


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: UNIVERSITY PARK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative We propose to develop a common data analysis medium—BRC.analytics—that would connect infectious disease researchers to data, tools, and workflows. The transformative tenets of the proposed system are: (1) giving access to an ensemble of data resources via a single workspace where data can be stored, combined, and analyzed; (2) enabling access to the majority of high quality open source tools and allow creation of complex workflows in the workspace; (3) ensuring that workspace in powered by powerful hardware capable of sustaining thousands of users analyzing large datasets; (4) providing several modes of access including a graphical user interface (GUI) as well as an Application Programming Interface (API). BRC.analytics will be a new type of knowledgebase that provides data, tools, and infrastructure as well as the “know-how” on applying this power effectively.

PI_NAMEs: FONNER, JOHN M.;HAEUSSLER, MAXIMILIAN ;NEKRUTENKO, ANTON  (contact);POND, SERGEI L KOSAKOVSKY;SCHATZ, MICHAEL

PROGRAM_OFFICER_NAME: RUTVISUTTINUNT, WIRIYA

PROJECT_TERMS: Address;Adoption;Algorithms;analytical tool;application programming interface;base;Bioinformatics;bioinformatics resource;bioinformatics tool;Biomedical Research;Communicable Diseases;Communities;Complex;computer infrastructure;computer science;Computer software;COVID-19 pandemic;cyber infrastructure;Data;data access;Data Analyses;Data Analytics;data resource;Data Set;data visualization;Databases;Dedications;design;Development;Disease Outbreaks;Disparate;Documentation;Educational workshop;Elements;Emergency Situation;Ensure;Environment;Event;experience;Funding;Galaxy;genome analysis;genome browser;Genomics;Geography;Goals;graphical user interface;Health;human genomics;Image;implementation strategy;Infectious Agent;Infrastructure;knowledgebase;large datasets;Link;metabolomics;Modeling;Motivation;multiple omics;open source;open source tool;Organism;pathogen;pathogenic microbe;portability;Process;Property;Proteomics;Protocols documentation;Provider;Public Health;Research;Research Personnel;Resources;response;Rest;Running;scale up;skills;Software Tools;Source;Standardization;Supercomputing;System;system architecture;Technology;Texas;Time;tool;Trainers Training;Training;webinar;Work

PROJECT_TITLE: An in integrated platform for multiomic analyses of pathogen and host data using scalable public infrastructure

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 RK-M (M1)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: MILWAUKEE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative We recently discovered that a key blood clot lysis protein, tissue-type plasminogen activator (tPA), in hepatocytes limits the production of apoB-lipoproteins in mice and cultured primary hepatocytes. The overarching goal of the Parent R01 proposal is to explore the underlying mechanisms by which hepatocyte tPA lowers plasma apoB- containing lipoprotein-cholesterol levels. In this supplement award, Ms. Maya Rodriguez proposes to investigate the potential mechanism by which tPA and PAI1 regulate lipid metabolism with the impact from immunological stimuli as a logical extension to the Aim 3 of the parent R01.

PI_NAMEs: ZHENG, ZE  (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Alteplase;Apolipoproteins B;Atherosclerosis;Award;Blood;Blood coagulation;Cardiovascular Diseases;career;career development;Career Mobility;Cholesterol;Chronic;Clinical Data;Clinical Research;college;COVID-19;Cytolysis;Data Analyses;Dyslipidemias;Educational process of instructing;experience;fatty liver disease;feasibility research;Fibrinolysis;Goals;Hepatic;Hepatocyte;IDL lipoproteins;Immunologics;Impairment;Inflammatory Response;interest;Knowledge;Learning;lipid metabolism;lipoprotein cholesterol;Lipoproteins;Low-Density Lipoproteins;medical schools;Mentors;Mus;Parents;particle;Physicians;Plasma;Plasminogen Activator;Plasminogen Activator Inhibitor 1;Postbaccalaureate;Production;programs;Proteins;Research;Research Design;Risk;Role;Science;Scientist;skills;Source;Stimulus;Therapeutic;Thrombosis;thrombotic;timeline;Very low density lipoprotein

PROJECT_TITLE: The role of hepatocyte tPA in hepatic VLDL production.


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The Johns Hopkins Summer Undergraduate Program in Kidney Science (SUPerKS) is designed to rebuild the pipeline of nephrologists and basic kidney scientists with talented people from diverse backgrounds by focusing on undifferentiated undergraduate students and seeding and reinforcing their interest in kidney research.

PI_NAMEs: SOZIO, STEPHEN MARTIN;WELLING, PAUL A (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Achievement;Address;Awareness;Basic Science;Biomedical Engineering;career;Clinical;Clinical Investigator;Clinical Sciences;Clinical Skills;cohort;design;Dimensions;Dryness;economic disparity;Educational Curriculum;Engineering;Equilibrium;Event;experience;faculty mentor;Functional disorder;Funding;Funding Mechanisms;Goals;hands on research;Immersion;improved;Individual;innovation;Institution;interest;Kidney;Kidney Diseases;Learning;matriculation;medical schools;Medicine;Mentors;Mentorship;Nephrology;operation;Participant;Personal Communication;Persons;Physiology;posters;precision medicine;Prevention strategy;programs;Public Health;recruit;Research;Research Personnel;Research Project Grants;Resources;Science;science teacher;Scientist;skills;social;student participation;Students;success;summer internship;summer program;Supervision;Talents;Technology;Training;Travel;undergraduate student;Underrepresented Minority;Undifferentiated;Universities;Work

PROJECT_TITLE: Johns Hopkins Summer UndergraduateProgram in Kidney Science

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: BOSTON

ORG_NAME: ASYMMETREX, LLC

ORG_STATE: MA

PHR: PROJECT NARRATIVE Although the importance of stem cells in human tissues as essential determinants of health and disease has been recognized for more than half a century, there has been no method available for their routine quantification. A small laboratory instrument that makes quantification of stem cells in human tissue cell samples convenient has the potential to reveal previously inaccessible knowledge that can improve human health and increase cures for human diseases and disorders.

PI_NAMEs: SHERLEY, JAMES L (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Acceleration;Address;Algorithmic Software;Algorithms;Animals;Biomanufacturing;Biomedical Research;Cell Count;Cell Culture Techniques;Cell Fraction;cell preparation;Cells;Cellular Assay;Clinical Trials;Computer Simulation;Computing Methodologies;Cord Blood Hematopoietic stem cells;Cornea;Data;Dental;design;Disease;dosage;Dose;drug development;drug discovery;Drug Evaluation;drug testing;Electronics;gene therapy;gene therapy clinical trial;graft function;head-to-head comparison;Health;health determinants;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hour;Human;human disease;human tissue;improved;innovation;instrument;interest;Kinetics;Knowledge;Laboratories;Liver Stem Cell;Malignant Neoplasms;Manuals;manufacture;mathematical algorithm;Medicine;Mesenchymal Stem Cells;Methods;Organ;Output;Patient-Focused Outcomes;Pharmacologic Substance;Phase;Preparation;prevent;Procedures;Production;prototype;Research;research and development;Role;Sampling;SCID Mice;Science;Small Business Innovation Research Grant;Source;Stem Cell Research;stem cell therapy;Stem cell transplant;stem cells;stemness;success;Technology;Testing;tissue preparation;tissue stem cells;tissue/cell culture;tissue/cell preparation;Tissues;transplantation medicine;transplantation therapy;Umbilical Cord Blood

PROJECT_TITLE: Design and production of an automated electronic tissue stem cell counter

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (12)]


NIH_SPENDING_CATS: Biotechnology;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: New York

ORG_NAME: TRAVERSE BIOTECH II INC

ORG_STATE: NY

PHR: Project Narrative  The aim of this project is to advance HPX-612, the first orally available immunotherapy that activates the innate immune system, for the treatment of visceral leishmaniasis. Visceral leishmaniasis, caused by the parasite  Leishmania, is prevalent in low- and middle-income countries, and current treatment options such as liposomal  amphotericin, pentavalent antimonials, and miltefosine are associated with significant toxicity and long treatment  duration, often requiring hospitalization. As a result, up to 400,000 individuals annually experience significant  morbidity and mortality. Herein this proposal, HPX-612 will be evaluated for efficacy in leishmaniasis, including  its pharmacokinetics and optimal dosing, before launching into rigorous pre-clinical development program.

PI_NAMEs: ROMET-LEMONNE, JEAN-LOUP  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acute;Affect;Agonist;Amphotericin;Amphotericin B;Area;assay development;Binding;Biotechnology;Blood;Cells;Clinical;Collaborations;combat;Communities;Country;Cutaneous Leishmaniasis;cytotoxicity;Disease;Dose;drug candidate;Drug Kinetics;Drug usage;efficacy evaluation;Ethanolamines;Europe;experience;experimental study;Formulation;Future;Genetic study;genetic variant;granulocyte;Hospital Costs;Hospitalization;Hospitals;Human;Human body;Immune;immune stimulatory agent;Immunologic Surveillance;Immunotherapy;improved;In Vitro;in vivo;Inbred BALB C Mice;Individual;Infection;Inflammatory;Injections;Innate Immune System;Intravenous;Kidney Failure;Kinetics;Laboratories;Left;Leishmania;Leishmania donovani;Leishmaniasis;lipid nanoparticle;Liposomes;Liver Failure;low and middle-income countries;Macrophage;Macrophage Activation;manufacturing quality;Marketing;Miltefosine;Monitor;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Names;neglected tropical diseases;New York;Nonmetastatic;novel;novel therapeutics;Nucleotides;Oral;Oral Administration;Osteosarcoma;overexpression;Pain;Parasites;Parasitic Diseases;Parasitology;Paromomycin;Pathogenicity;Pathway interactions;Pattern recognition receptor;Peptides;Peptidoglycan;Persons;Phagocytes;pharmacologic;Pharmacologic Substance;Phase;Phlebotominae;Phosphatidylethanolamine;pre-clinical;preclinical development;Predisposition;Principal Investigator;Program Development;Proteins;quality assurance;resistant strain;Resource-limited setting;response;Safety;side effect;Signal Transduction;standard of care;Symbiosis;targeted treatment;Therapeutic;Therapeutic Effect;Therapeutic Index;therapy development;Time;Toxic effect;transmission process;treatment duration;Underserved Population;Universities;Vector-transmitted infectious disease;Visceral;Visceral Leishmaniasis;Work

PROJECT_TITLE: Orally available NOD2 agonist, HPX-612, for the treatment of visceral leishmaniasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-F (12)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Cannabinoid Research;Complementary and Integrative Health;Natural Products;Therapeutic Cannabinoid Research

ORG_CITY: SAN DIEGO

ORG_NAME: CELLIBRE INC

ORG_STATE: CA

PHR: Narrative Currently, pure pharmaceutical grade cannabinoids are purified from plant-derived extracts through complex, unstandardized, and high-cost purification techniques. As interest in utilizing cannabinoids as active pharmaceutical ingredients grows, and subsequently the number of trials using cannabinoids increases, heavy strain is put on cannabinoid supply chains. Cellibre is developing a microbial engineering and biofactory platform for sustainable, scalable, and cost-effective production of pharmaceutical grade cannabinoids and related compounds to eliminate the primary pain points currently associated with plant-based cannabinoid production, reducing the costs of manufacturing and purification by 5–10X, increasing access to minor cannabinoids and analogs for pharmaceutical studies, reducing competition with food crops and environmental impacts, and resulting in a smaller manufacturing footprint.

PI_NAMEs: KAMBOURAKIS, SPIROS  (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Acceleration;Acids;addiction;Agriculture;analog;Anti-Bacterial Agents;Biomedical Engineering;Bioreactors;cannabigerol;cannabigerolic acid;cannabinoid drug;cannabinoid treatment;Cannabinoids;Cannabis;Cannabis sativa plant;Clinical Trials;CNR1 gene;CNR2 gene;commercialization;Complex;Consumption;cost;cost effective;Decarboxylation;Desire for food;Development;Diabetes Mellitus;Dimethylallyltranstransferase;Diphosphates;Disease;drug development;Economic Models;endogenous cannabinoid system;Engineering;Environment;Environmental Impact;Enzymes;Epilepsy;FDA approved;Fermentation;Food;Formulation;Foundations;Friends;G-Protein-Coupled Receptors;Huntington Disease;improved;Inflammatory;interest;Investments;Learning;Legal patent;Malignant Neoplasms;manufacture;manufacturing cost;manufacturing process;Marketing;Medical;Metabolic Pathway;Methods;microbial;Minor;Neurodegenerative Disorders;novel;obesity management;obesity treatment;oxidation;Pain;Pain management;Parkinson Disease;Pathway interactions;Pesticides;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Plants;polyketide synthase;Process;Production;supply chain;Techniques;Technology;technology platform;Technology Transfer;Therapeutic;Time;Water;Work

PROJECT_TITLE: A microbial engineering platform for sustainable, scalable, and cost-effective production of pharmaceutical grade cannabinoids and related compounds

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-G (10)]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative The project seeks to identify the viral and immune determinants of heterogenous outcomes of hepatitis C virus infection and pathogenesis. This knowledge is crucial for the development of new strategies to prevent chronic hepatitis C virus infections and associated liver diseases.

PI_NAMEs: KAPOOR, AMIT  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute;adaptive immune response;Agonist;Alleles;Animal Model;Animals;Antigens;B-Lymphocytes;CD8-Positive T-Lymphocytes;Cell Aggregation;Cells;Chronic;Chronic Hepatitis C;chronic infection;Cirrhosis;comparative;Comparative Biology;Data;Development;deviant;disease phenotype;Evolution;exhaust;experimental study;Fibrosis;Frequencies;Genes;genetic resource;Haplotypes;HCV Animal Models;Hepatitis C;Hepatitis C virus;Human;Immune;Immune Evasion;Immunity;Immunocompetent;immunogenicity;Immunologics;in vivo;Inbreeding;Infection;Inflammation;Inflammatory;Innate Immune Response;insight;intrahepatic;Knowledge;Liver;liver development;Liver diseases;Modeling;mouse model;Mus;Myeloid Cells;Nature;novel;novel strategies;Outcome;Parents;passive antibodies;Pathogenesis;Persons;Phase;Population;prevent;Proteins;Rattus;Rattus norvegicus;Reporting;Resources;Risk;RNA Viruses;Rodent;Role;Serial Passage;Severities;single-cell RNA sequencing;Solid;T cell response;T-Lymphocyte;Testing;Toll-like receptors;transcriptome;Validation;Variant;Viral;Viral Pathogenesis;Viremia;Virus

PROJECT_TITLE: Animal Model to study heterogeneous outcomes of HCV Infection and Pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 DF-M (M1)]


ORG_CITY: ITHACA

ORG_NAME: HALOMINE, INC.

PHR: Project Narrative Central venous catheters provide lifesaving therapy to millions of patients every year; however, thrombosis and infection complications are high and associated with device failure, increased healthcare costs, patient morbidity, and mortality. Our novel approach is to combine antifouling and antimicrobial killing functionalities into a new polymer additive product (HaloAddTM) that catheter manufacturers can blend with thermoplastic polyurethane to prevent catheter-associated infections and thrombosis. This cost-effective and simple approach will have a meaningful impact on the safety and quality of life of patients who require a catheter by minimizing complications without using systemic anticoagulation and antibiotic treatments that will greatly decrease healthcare costs.

PI_NAMEs: OZKAN, EKREM  (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Address;Adhesions;Adoption;Adsorption;Agreement;Animals;Anti-Bacterial Agents;Anti-Inflammatory Agents;anti-microbial drug;Antibiotic Therapy;Antibiotics;Anticoagulation;antimicrobial;Awareness;Bacteria;Biocide;Biological Assay;biomaterial compatibility;Bioreactors;Blood;Blood Circulation;catheter related infection;Catheters;Cells;Chemicals;Chlorine;Clinical Trials;Collaborations;Complex;copolymer;cost;cost effective;cytotoxicity;Data;Death Rate;Devices;Drug resistance;drug resistance development;Effectiveness;Electrostatics;Engineering;Equipment Malfunction;Event;Generations;Goals;Growth;Health Care Costs;health care settings;Healthcare Systems;hemocompatibility;Hour;Hydration status;In Vitro;in vivo;Incubated;Infection;Infection Control;Inflammation;Intensive Care Units;Intravenous;Length of Stay;Life;Manufacturer;mechanical properties;Microbial Biofilms;microorganism;monomer;Montana;Morbidity - disease rate;mortality;novel;novel strategies;pathogen;Patients;Performance;Phase;Physiological;Polymers;Polyurethanes;prevent;Prevention;Property;Proteins;Quality of life;Reaction;Recording of previous events;Resistance;Safety;Sampling;Sepsis;Skin;Stream;success;Surface;systemic toxicity;Testing;Thrombin;Thrombosis;Thrombus;Tube;United States;Universities;Venous;Water;Work

PROJECT_TITLE: Novel Polymer Additives for Infection Control Intravenous Catheters

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-F (10)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: FORT MYERS

ORG_DEPT: BIOLOGY

ORG_NAME: FLORIDA GULF COAST UNIVERSITY

ORG_STATE: FL

PHR: Ciguatera poisoning (CP) is a form of seafood poisoning that affects tens of thousands of people on an annual basis and is expected to increase with climate change impacts. The Greater Caribbean Center for Ciguatera Research (GCCCR) was established to study the anticipated intensification of CP in the Greater Caribbean Region due to warming sea surface temperatures and reef degradation associated with climate change. Hurricane Ian caused severe damage to the Florida Gulf Coast University Vester Field Station, hindering progress and forming the basis for our request for an Administrative Supplement for the GCCCR project through this funding mechanism.

PI_NAMEs: PARSONS, MICHAEL  (contact);SOBOL, ROBERT W

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Address;Administrative Supplement;Affect;Alabama;Algae;Back;Boat;Caribbean region;Cell Wall;Cells;Ciguatera Poisoning;Ciguatoxins;climate change;Collaborations;Communities;community engagement;Consumption;coral;Coupled;Dinophyceae;Disease;Disease Outbreaks;Docking;economic impact;Educational Activities;Equipment;experience;Financial Support;Fishes;Floor;Florida;Food Webs;Formulation;Frequencies;Funding;Funding Mechanisms;Gambierdiscus;General Population;genotoxicity;Geography;Goals;gulf coast;harmful algal blooms;Hawaii;Health;Human;Human Resources;Hurricane;Infrastructure;Institution;Invertebrates;Island;Laboratories;Left;Lifting;Lipids;Malignant Neoplasms;Manuscripts;marine;Medical;Metabolic Biotransformation;Metabolism;Mexico;Microscope;Molecular;Movement;Muscle;Nerve;Neurotoxins;Oceanography;Oceans;Output;Persons;Play;Poisoning;Productivity;programs;Public Health;Publishing;Puerto Rico;repaired;Research;Research Activity;Research Personnel;Research Project Grants;Resources;response;Risk;Role;Sampling;Schedule;Science;Scientist;Sea;Seafood;seafood poisoning;Secure;sensor;Site;Sodium Channel;sodium ion;Students;success;Surface;Symptoms;Syndrome;Temperature;Texas;Time;Toxin;Translating;United States;United States Virgin Islands;Universities;voltage;Vulnerable Populations;Work


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative The use of in vivo imaging approaches paired with genetically encoded sensors and actuators (e.g., calcium imaging, optogenetics, and others) to study visual function has led to fundamental discoveries in visual neuroscience, but also has tremendous potential to transform pre-clinical development of therapies and treatment of blinding diseases. The 33rd Symposium of the Center for Visual Science brings together a diverse array of scholars who are leaders in these state-of-the-art methods to study and manipulate visual function in the eye and brain at unprecedented resolution and scale. The meeting will provide a forum to discuss recent discoveries, and foster new collaborations between technology developers, neuroscientists and clinicians at all career stages with an emphasis on large animal models and translation.

PI_NAMEs: GOMEZ-RAMIREZ, MANUEL ;MCGREGOR, JULIETTE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Anesthesia procedures;Animal Model;Animals;Automobile Driving;Award;Back;Basic Science;Behavior;Brain;Calcium;career;Career Choice;career development;cell type;Collaborations;Communities;Development;Disease;disease model;Educational workshop;Emerging Technologies;Engineering;experimental study;Eye;Faculty;Ferrets;fluorescence imaging;Fostering;Genetic;Goals;graduate student;Human;Image;imaging approach;Immune response;improved;in vivo;in vivo imaging;insight;Knowledge;Label;Light;Mammals;meetings;Mentors;Mentorship;Methods;Movement;neural;neural circuit;neuroimaging;Neurophysiology - biologic function;neuroregulation;Neurosciences;next generation;Noise;nonhuman primate;novel;Optics;optogenetics;Outcome;Postdoctoral Fellow;preclinical development;Preclinical Testing;Process;professional atmosphere;programs;Research Personnel;Resolution;respiratory;Rodent;Role;Scientist;sensor;Shapes;Signal Transduction;Strategic Planning;success;symposium;Technology;technology development;Therapeutic;therapy development;Tissues;tool;Training;Transfection;translational applications;Translational Research;translational study;Translations;Travel;Viral;Vision;vision development;Vision research;vision science;Visual;visual neuroscience;Visual Perception;visual processing;Visual System;Work

PROJECT_TITLE: Symposium on imaging and modulation of neural activity in vivo: From the Eye to the Brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (04)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: DOVER

ORG_NAME: EINSENCA INC.

ORG_STATE: DE

PHR: Aberrant oxidative neuroinflammation is a key early event in the development of Alzheimer’s disease (AD). We are developing a noninvasive positron emission tomography (PET) imaging method to quantify and monitor myeloperoxidase-mediated oxidative stress in the AD brain. Technical assistance with intellectual property protections will be critical for commercialization of these innovative PET imaging methods.

PI_NAMEs: LARSON, ANDREW CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Administrative Supplement;Agreement;Alzheimer's Disease;Alzheimer's disease brain;Businesses;clinical translation;commercialization;Development;Disease;Event;experience;Freedom;Funding;Future;General Hospitals;imaging modality;Imaging technology;innovation;Intellectual Property;Laws;Lawyers;Legal patent;Licensing;Massachusetts;Mediating;Mediation;Monitor;Nature;neuroinflammation;non-invasive imaging;Oxidative Stress;Peroxidases;Positron-Emission Tomography;Progressive Disease;Research;Rights;Services;Technology;Validation;Work

PROJECT_TITLE: PET Imaging of Damaging Neuroinflammation in Alzheimer's Disease Technical and Business Assistance (TABA)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Lymphatic Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Our proposal will test the hypothesis that neurotropic flaviviruses can use newly described anatomical connections between the periphery and the central nervous system to enter the brain and cause disease. We will determine whether early-in-life viral infection can increase the severity of neurotropic virus infection in adulthood.

PI_NAMEs: DIAMOND, MICHAEL S (contact);KIPNIS, JONATHAN

PROJECT_TERMS: Address;Adult;Affect;Age;Aging;Alpha Virus;Alphavirus Infections;Anatomy;Animals;Anti-viral Response;Arachnoid mater;Axonal Transport;Blood - brain barrier anatomy;Body Weight decreased;Brain;Bypass;cell type;Cells;Central Nervous System;Central Nervous System Infections;Cessation of life;Communication;Congenital Abnormality;Cre driver;Culicidae;Data;Development;Diamond;Disease;Dura Mater;Encephalitis;Endothelial Cells;Fetal Development;Fetal Growth Retardation;Fever;Fibroblasts;Flavivirus;Flavivirus Infections;Gene Expression Profile;Genetic Transcription;Immune;Immune response;Immune system;Immunity;Immunology procedure;in utero;inducible Cre;Infection;Inflammation;Interferon Type II;Invaded;Label;Laboratories;Life;Link;Liquid substance;lymphatic vessel;Malaise;Mediating;Mediator;Meningeal;Meningeal lymphatic system;Meninges;Meningitis;Microcephaly;migration;mortality;mouse model;Mus;Neonatal;neonate;Nervous System Physiology;Neuropathogenesis;neuropathology;neurotropic;neurotropic virus;new therapeutic target;novel;pathogen;Pathologic;Patients;Peripheral;Predisposition;Pregnant Women;Process;Public Health;Regulation;response;Risk;Role;Route;Severities;Signal Transduction;single-cell RNA sequencing;Spontaneous abortion;Stromal Cells;Structure;Subarachnoid Space;Symptoms;Testing;Therapeutic Intervention;transcytosis;transmission process;Veins;Venezuelan Equine Encephalitis Virus;Viral;Viral Load result;Virion;Virus;Virus Diseases;West Nile virus;Western Equine Encephalitis Virus;Wild Type Mouse;Zika Virus;ZIKV infection

PROJECT_TITLE: Meningeal Immunity and Viral Neuropathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LG-M (M1)]


ADMINISTERING_IC: GH

IC_NAME: Center for Global Health

ORG_CITY: NAKHON PATHOM

ORG_COUNTRY: THAILAND

ORG_FIPS: TH

ORG_NAME: MAHIDOL UNIVERSITY

PHR: Project narrative:  We propose to develop molecular diagnostic tools (TaqMan Array Card platform and POCT CRISPR) for centralized and decentralized laboratories and establish a genetic analysis platform (Short-read and Long-read sequencing), bioinformatic pipelines, and microbial genomic database to facilitate genomic surveillance of respiratory viruses, arboviruses, bacterial STIs, and nosocomial bacterial pathogens, including antimicrobial resistance. These multi-level tools and systems will facilitate early detection and rapid response to EIDs and AMR across different levels of government and local communities.

PI_NAMEs: HORTHONGKHAM, NAVIN  (contact)

PROJECT_TITLE: RFA-GH-23-003, THAI-GER: THAIland Genomic surveillance of Emerging infectious diseases facilitating Rapid response


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: This high risk / high reward exploratory R21 project will make breakthroughs in understanding chemical- induced occupational allergy (asthma, hypersensitivity pneumonitis, skin disease). We will identify small molecules (peptides) that mimic the structure of chemical allergens by combining cutting edge technology with unique reagents generated in our laboratory. The results and newly identified chemical allergen mimics (mimotopes) will lead to new diagnostics, surveillance approaches, and potential therapies.

PI_NAMEs: WISNEWSKI, ADAM  (contact)

PROJECT_TITLE: Discovering epitope mimics (mimitopes) of chemical allergens that cause occupational asthma

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ORG_CITY: MANHATTAN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: Project Narrative Occupational hearing loss (HL) is a burden in regards to health care cost, worker performance, and quality of life. Hearing protection can prevent hearing loss, but workers often choose not to wear it because of listening difficulties that arise while wearing. This project will measure these difficulties, their impact on choice to wear HPDs, and test an auditory training approach to alleviating them.

PI_NAMEs: WISNIEWSKI, MATTHEW G. (contact)

PROJECT_TITLE: Listening while wearing hearing protection: performance dynamics, choice to wear, and impacts of training


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: PISCATAWAY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: A novel passive sampler to assess personal exposures to airborne biological agents A novel Personal Rutgers Electrostatic Passive Sampler (P-REPS) will be developed and tested to assess personal exposures to bioaerosols in occupational environments. P-REPS will consist of a permanently polarized polymer film wound into a spiral and a 3D-printed film holder. The new sampler will advance our capabilities to determine exposures to biological aerosols, especially due to its pump-less operation and long sampling time frames.

PI_NAMEs: MAINELIS, GEDIMINAS  (contact)


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Women have been deterred from working in the skilled trades, partially due to the challenging physical, social and organizational work environment, which highlights the need to study this vulnerable, disproportionately at- risk population and better understand the challenges that jeopardize skilled tradeswomen’s safety, health, and well-being. Although fostering equitable gender representation, diversity, fairness, and inclusion is essential for the skilled trades, few studies or publications have addressed the issue or explored strategies for improving working conditions for the purpose of enhancing opportunities for skilled tradeswomen. We will utilize the Sociotechnical Systems and Total Worker Health® approaches to assess the joint impact of factors impeding or enhancing tradeswomen’s safety, health, and well-being, identify needs and improvement strategies, and then disseminate the generated knowledge to key stakeholders and the public in support of a more equitable and diverse workforce in industries that rely on the skilled trades.

PI_NAMEs: HUANG, YUENG-HSIANG  (contact)

PROJECT_TITLE: Building a Safe, Healthy, and Respectful Workplace for Tradeswomen: A Total Worker Health Approach.


ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Project Narrative This project will provide the first evidence on racial and ethnic disparities in the economic consequences of injury by imputing race and ethnicity data to administrative data on injured workers from the California workers’ compensation system. By quantifying how a wide range of observed factors contribute to disparities in earnings and employment losses, our study will provide policymakers and researchers valuable information about how safety and disability prevention interventions could be targeted to have the greatest impact on inequity in the financial burden of occupational injury and illness. This research supports NIOSH’s objective of reducing disparities related to occupational injuries and illnesses.

PI_NAMEs: DWORSKY, MICHAEL  (contact)

PROJECT_TITLE: Racial and Ethnic Disparities in the Economic Consequences of Occupational Injuries


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This project will develop a new sampling and analytical method and study the factors affecting the suitability of this new method of fiber sampling. The goal of this project is to design a new method and determine the collection efficiency of the new sampling method and the reduction in analytical time by the image processing program.

PI_NAMEs: TSAI, CANDACE SUJUNG  (contact)

PROJECT_TITLE: Fiber sampling technique and counting protocol development for carbon nanotubes


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

PHR: Project Narrative: Veteran suicide death is a national crisis. Risk factors include emotion dysregulation, which occurs across mental health disorders. Dialectical behavior therapy (DBT) is an evidence-based suicide intervention that targets emotion dysregulation but is resource-intensive and not widely available at VHA. A more efficient evidence-based DBT Skills Group (DBT-SG) is associated with reduced suicidal ideation and emotion dysregulation and likely more feasible to implement at VHA. We propose a randomized controlled trial to test whether DBT-SG, compared to VHA treatment-as-usual, reduces Veteran suicide attempt, the first study of its kind at VHA. Before, during, and after the trial, we will assess stakeholder viewpoints about DBT-SG, including barriers to implementing DBT-SG and factors that might make it more feasible to use for Veterans, clinicians, and leadership. Study results will tell us (1) whether DBT-SG is more effective than usual VHA treatment for high-risk Veterans, and (2) how VHA can best implement DBT-SG to reduce suicide risk.

PI_NAMEs: DECKER, SUZANNE ELIZABETH (contact);MARTINO, STEVE

PROJECT_TERMS: Address;Administrator;Adoption;Affect;Aftercare;Characteristics;Clinic;Clinical;Clinical effectiveness;Clinical Practice Guideline;clinical research site;Complement;Coping Skills;Data;Development;Diagnosis;Diagnostic;Diagnostics Research;Dialectical behavior therapy;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness trial;effectiveness/implementation hybrid;Elements;emotion dysregulation;emotion regulation;Emotions;Evaluation;evidence base;Feeling suicidal;follow-up;formative assessment;Health Personnel;high risk;hybrid type 1 trial;Hybrids;implementation barriers;implementation facilitators;implementation strategy;improved;Individual;innovation;Intervention;Interview;Knowledge;Leadership;Machine Learning;Measures;Medical center;Mental disorders;Mental Health;Mental Health Services;Methodology;Methods;military veteran;multi-site trial;operation;Outcome;Outpatients;Participant;Phase;prevent;Prevention;primary outcome;Process;process improvement;programs;Promoting Action on Research Implementation in Health Services framework;psychologic;Psychotherapy;Published Comment;Randomized;randomized trial;Randomized, Controlled Trials;reducing suicide;Research;Resources;Risk Factors;Safety;Sampling;screening;Site;skills;Structure;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;System;Testing;Time;treatment as usual;treatment group;uptake;Veterans

PROJECT_TITLE: A Hybrid Effectiveness-Implementation Multisite Trial of a Dialectical Behavior Therapy Skills Group for Veterans at High-Risk for Suicide Attempt

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Obesity;Physical Activity;Prevention

ORG_CITY: ORANGEBURG

ORG_NAME: NATHAN S. KLINE INSTITUTE FOR PSYCH RES

PHR: NARRATIVE. The openly-shared NKI-Rockland Sample has provided a model for lifespan imaging studies and has led to more than two hundred publications to date. This competing renewal application will provide a comprehensive data resource to enrich and expand resources available for brain research and biomarker discovery across the lifespan. Construction of the proposed sample was organized around three main themes: 1) integration of advanced measures for brain and body, 2) real-world strategies for characterizing individuals, and 3) enhanced focus on the relationships between obesity and cardiovascular fitness on brain function.

PI_NAMEs: COLCOMBE, STAN J;MILHAM, MICHAEL PETER (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: 3-Dimensional;Acceleration;actigraphy;Adult;Age;Behavior;Behavioral;biomarker discovery;Biometry;Body Composition;Body measure procedure;Brain;brain based;brain research;cardiovascular fitness;Caring;Categories;Cellular Phone;Chronology;Cognition;Cognitive;cognitive performance;cognitive task;Collection;Communities;connectome;Data;data archive;data integration;data resource;data sharing;density;design;Development;Diffusion Magnetic Resonance Imaging;Dimensions;DSM-V;Ecological momentary assessment;EEG-based imaging;Electroencephalography;Electromyography;fitness;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Funding;Future;Galvanic Skin Response;Genetic;Goals;Health;Human;human very old age (85+);Image;imaging study;Imaging technology;improved;indexing;Individual;informant;inter-individual variation;International;Intervention;Journals;life span;Literature;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Maps;Measurement;Measures;member;Mental disorders;Mental Health;Methods;Modality;Modeling;Moods;morphometry;Motion;multimodal data;multimodality;National Institute of Mental Health;neuroimaging;next generation;novel;Obesity;Performance;Phenotype;Photography;Physical activity;Physiological;Physiology;Preventive;Procedures;Process;prospective;Protocols documentation;Psychiatry;Psychopathology;Publications;Questionnaires;Research;Research Personnel;Resources;Rest;Risk;Risk Factors;Sampling;Scalp structure;Science;sensor;sex;smartphone application;Source;source localization;Stimulus;Structure;substance use;Technology;Testing;United States National Institutes of Health;Variant;visual tracking;VO2max;Voice;wearable device;Work

PROJECT_TITLE: The NKI Rockland Sample II: An Open Resource of Multimodal Brain, Physiology & Behavior Data from a Community Lifespan Sample

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Protein Arginine Methyltransferase 5 (PRMT5) regulates gene transcription by methylating three of the four core histones. I will reveal how PRMT5 recognizes and modifies histones H2A and H4 using a combination of biochemical and structural techniques. Understanding the mechanism of PRMT5’s histone specificity will further insights into PRMT5’s role in gene expression and support ongoing efforts in structure-based drug design of PRMT5 inhibitors.

PI_NAMEs: RAHMAN, SANIM  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Acute Myelocytic Leukemia;Affinity;ARG2 gene;Arginine;Binding;Binding Proteins;Biochemical;Biological Assay;Biological Process;Biophysics;career;Cell Nucleus;Chromatin;Chromatin Modeling;Colon Carcinoma;Complex;Cryoelectron Microscopy;Cytoplasm;Cytosol;Data;Deposition;design;Development;dimer;Drug Design;Enzyme Kinetics;Enzymes;Epithelium;Eukaryota;Gene Expression;gene repression;Genes;Genetic Transcription;Histone H2A;Histone H2B;Histone H3;Histone H4;histone methylation;histone methyltransferase;histone modification;Histones;Human;In Vitro;in vivo;inhibitor;insight;knock-down;Knowledge;Lysine;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;malignant stomach neoplasm;Mesenchymal;Metastasis Suppressor Genes;Methylation;Methyltransferase;Modification;Molecular;Molecular Chaperones;Nucleosomes;overexpression;Post-Translational Protein Processing;protein function;Protein-Arginine N-Methyltransferase;Proteins;reconstitution;recruit;Research;Research Personnel;Role;screening;Small Interfering RNA;Specificity;Structure;Substrate Specificity;Techniques;Testing;Training;Transcriptional Regulation;Ubiquitination;Work;Writing

PROJECT_TITLE: Molecular Basis of Histone Methylation by PRMT5


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: BALTIMORE VA MEDICAL CENTER

PHR: The time following discharge from psychiatric hospitalization is a high-risk period and has been associated with a range of negative outcomes including high rates of hospital readmission and suicide. The purpose of this proposal is to: 1) create a Peer Specialist facilitated intervention, called Recovery Bridge, designed to facilitate the transition from inpatient psychiatric hospitalization to community living; 2) examine feasibility, fidelity, and acceptability; and preliminarily explore the impact of the intervention on: a) readmission rates and connection to outpatient care compared to a control group identified from administrative data; and b) change in recovery and quality of life measures over time in the intervention participants. Results from the proposed open pilot trial will set the stage for next steps including a larger effectiveness trial followed by a possible hybrid-I effectiveness/implementation trial to inform future dissemination and implementation of the intervention more broadly across the VA.

PI_NAMEs: GOLDBERG, RICHARD WARREN (contact)

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Advocacy;Ambulatory Care;Anxiety;Area;Benchmarking;Caring;Clinical;clinical practice;Clinical Trials;Communities;community living;Compensation;Control Groups;Crisis Intervention;Data;design;Development;Dissemination and Implementation;Effectiveness;effectiveness evaluation;effectiveness trial;effectiveness/implementation trial;Elements;Emotional;empowerment;Evaluation;experience;functional outcomes;Future;Health;Health Services Accessibility;high risk;Homelessness;hospital readmission;Hospitalization;Hospitals;Hybrids;implementation intervention;improved;Individual;Infrastructure;innovation;inpatient psychiatric treatment;inpatient service;Inpatients;Internet;Intervention;intervention participants;Intervention Trial;Investigation;Knowledge;Manuals;Measures;Mental Depression;Mental Health;Mental Health Services;Methodology;Methods;military veteran;Outcome;outpatient programs;Outpatients;Patients;peer;peer support;pilot trial;Play;Positioning Attribute;prevent;programs;Provider;Psychiatric Hospitals;psychiatric inpatient;psychoeducation;Quality of life;readmission rates;Recovery;Recovery Support;Research;Resources;Role;Scientific Advances and Accomplishments;Services;severe mental illness;social;sound;Source;Specialist;Specific qualifier value;Structure;Subcategory;Substance abuse problem;Suicide;Suicide prevention;Systems Integration;Technology;Testing;Time;tool;Veterans;Vocational rehabilitation;Work

PROJECT_TITLE: Recovery Bridge: A Peer Facilitated Intervention to help bridge the transition from psychiatric inpatient hospitalization to living in the community


ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: As part of comprehensive suicide prevention, VA integrated mental and physical health services to better detect and treat depression. Depression detection and management processes are complex, involve multilevel stakeholders, and subject to significant disruption from COVID-19 and from resulting expansion of telehealth aiming to preserve care access. To improve virtual and in-person services for the VA primary care population during recovery, this proposal will examine how the pandemic disrupted depression care delivery mechanisms and patient outcomes (e.g., psych hospitalizations, suicides). The pandemic provides an opportunity to engage multilevel stakeholders to improve upon VA’s management of depression and suicide prevention for the entire Veteran population. This proposed research will provide the basis for testable hypotheses (e.g., acceptable virtual depression treatments in primary care), and clinical recommendations (e.g., satisfactory virtual provider- to-provider handoffs for new patient referrals), to improve hybrid (virtual/in-person) VA depression services.

PI_NAMEs: LEUNG, LUCINDA B (contact)

PROJECT_TERMS: acute care;Address;Adoption;adverse outcome;Affect;Behavior;behavior change;care delivery;care seeking;Caring;Clinic;Clinical;collaborative care;Complex;connected care;Consultations;cost;COVID-19;COVID-19 pandemic;current pandemic;Data;Death Rate;depression prevention;depressive symptoms;Detection;digital divide;disability;Drops;effective therapy;experience;Feedback;Feeling suicidal;follow-up;Functional impairment;Future;Guidelines;Health;Health Services Accessibility;Hospitalization;Hospitals;Hybrids;improved;innovation;Interruption;Intervention;Interview;Los Angeles;Mental Depression;Mental Health;Mental Health Services;Methodology;Methods;military veteran;Minority;Modality;Modeling;Modernization;Morbidity - disease rate;mortality;multidisciplinary;Outcome;pandemic disease;pandemic disruption;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;physical conditioning;physical health service;Population;population based;population health;preservation;Primary Care;Primary Nursing Care;Process;Provider;provider to provider;psychiatric emergency;Quality Indicator;Quality of Care;Recommendation;Recovery;Research;response;routine screening;screening;Services;Solid;Specialist;suicidal;suicidal behavior;suicidal risk;Suicide;suicide mortality;Suicide prevention;System;telehealth;Testing;Time;Time Series Analysis;tool;Veterans;virtual;virtual healthcare;Visit;Work

PROJECT_TITLE: Leveraging COVID-19 to modernize depression care for VA primary care populations


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The Endosomal Sorting Complex Required for Transport (ESCRT) machinery is known for its fundamental roles in remodeling cellular membranes to enable membrane protein degradation, HIV budding, and cell division. The work in this proposal builds on and extends our discovery that ESCRTs also stabilize and repair membranes throughout the endolysosomal network. Insight into how this machinery maintains compartmental membrane integrity has important implications for understanding inflammatory responses, pathogen invasion, and mechanisms underlying necrotic cell death.

PI_NAMEs: HANSON, PHYLLIS I (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TITLE: ANALYSIS OF ESCRT FUNCTION IN ENDOLYSOSOMAL TRAFFICKING

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: Traumatic brain injury (mTBI) is a major cause of morbidity in the Veteran population. Synapse alterations represent an underappreciated area in chronic TBI pathobiology. Based on our preliminary data, we hypothesize that (i) TBI can cause sustained down-regulation of protein complexes at the pre-synaptic terminal associated with diminished vesicular neurotransmitter release function, and that (ii) TBI can also destabilize post-synaptic density proteins leading to reduced functions of glutamate receptors. (iii) We propose to study both cortical impact and repeated closed-head injury–induced chronic synaptic damage and dysfunctions as facilitated using synaptosome preparations isolated from affected brain regions. (iv) We will also examine if oral treatment of a BBB-crossing antioxidant Mitoquinone (MitoQ) can mitigate post-TBI synaptic structural/functional deficits, restore synaptic mitochondrial function and improve chronic neurobehavioral outcome.

PI_NAMEs: WANG, KEVIN KA WANG (contact)

PROJECT_TERMS: Activities of Daily Living;Affect;Afghanistan;Amygdaloid structure;Antioxidants;Anxiety;Area;Attenuated;Behavioral;Binding;blood-brain barrier crossing;Brain;Brain region;Calcium;Calmodulin;Caring;Chronic;Chronic Phase;Closed head injuries;cognitive function;controlled cortical impact;Corpus striatum structure;Data;density;Diagnosis;DLG4 gene;Dopamine D1 Receptor;Dopamine D2 Receptor;Dopamine Receptor;Down-Regulation;Dyes;Enzyme-Linked Immunosorbent Assay;Face;Functional disorder;GABA-A Receptor;gephyrin;Glutamate Receptor;Glutamates;Healthcare;Hippocampus;Immunoelectron Microscopy;improved;injured;Injury;interest;Iraq;Laboratories;Left;Lipids;Literature;Measures;Memory;Methods;mild traumatic brain injury;Military Personnel;military veteran;Mission;Mitochondria;mitoquinone;Modeling;Modification;Morbidity - disease rate;morris water maze;Mus;Names;neurobehavior;neurobehavioral;neurogranin;neurological rehabilitation;neurotransmission;neurotransmitter release;Neurotransmitters;novel;novel therapeutics;Oral;Oral Examination;Outcome;oxidation;Oxidative Stress Induction;pharmacologic;Pilot Projects;Play;postsynaptic;postsynaptic density protein;Postsynaptic Membrane;Prefrontal Cortex;Preparation;presynaptic;Presynaptic Terminals;Process;protein B;protein complex;Proteins;Proteolysis;Publishing;Rain;receptor;receptor density;Recovery;Research;Role;Scaffolding Protein;Sensory Receptors;Stains;Structural Protein;Structure;Synapses;Synaptosomes;Time;Traumatic Brain Injury;Veterans

PROJECT_TITLE: Persistent Pre- and Post-Synaptic Changes After Moderate Traumatic Brain Injury and Mitigation with MitoQ

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Cystic fibrosis is a devastating genetic disease that involves multiple organ systems and leads to premature death; therapeutic advances have extended lifespans and improved quality of life, but patients still suffer from airway infections, in addition to CF-related diabetes, digestive complications, and inflammatory responses. Our Center catalyzes new research in preclinical drug development, gut disease and diabetes and changes in patient microbiomes. We believe that these phenomena are interconnected, and that parallel investigations, coupled by powerful new data-science strategies can find new therapeutic approaches for CF patients by understanding the complex underlying biology.

PI_NAMEs: MADDEN, DEAN R (contact)

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Acceleration;Address;Affect;Antibiotics;antimicrobial;Archives;Area;Award;base;Basic Science;Bioinformatics;Biology;Biostatistics Core;Body System;career development;Cessation of life;Chronic;Clinical;Clinical Research;Coculture Techniques;cohort;Collaborations;commensal microbes;Communities;community center;Complex;complex data;Coupled;Cystic Fibrosis;cystic fibrosis patients;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Data Science;Data Set;data submission;Databases;Development;Diabetes Mellitus;Disease;dysbiosis;Ecology;Educational workshop;Endowment;Epithelium;Evaluation;extend lifespan;Extramural Activities;Faculty;forging;Fostering;Foundations;Functional disorder;Funding;gastrointestinal;Genetic Diseases;Goals;gut dysbiosis;gut microbes;host-microbe interactions;Immune;Immune response;Immunity;improved;improved outcome;Inflammatory Response;innovation;insight;Institution;interest;interoperability;Intervention;Investigation;Liver diseases;Lung;Malnutrition;Mediating;member;Metabolic;Microbe;microbial;microbial community;microbiome;Mining;Mission;Modeling;Monitor;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;novel;novel strategies;novel therapeutic intervention;novel therapeutics;open data;Organ;Outcome;Pancreatitis;Pathogenesis;pathogenic microbe;Patients;Pharmaceutical Preparations;Pilot Projects;pre-clinical;Preclinical Drug Development;premature;programs;Quality of life;recruit;Research;Research Personnel;Resources;Respiratory Tract Infections;Services;Signal Transduction;Structure;Symptoms;synergism;System;systemic inflammatory response;Therapeutic;Tissues;tool;Training;Translational Research;translational study;Virulence;Work

PROJECT_TITLE: DartCF: The Dartmouth Cystic Fibrosis Research Center


NIH_SPENDING_CATS: Cystic Fibrosis;Lung;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PROJECT_TERMS: Achievement;Address;Advisory Committees;Ally;Applications Grants;Area;Award;Basic Science;Biology;Biomedical Research;Clinical;Collaborations;Communication;Communities;conflict resolution;Core Facility;Creativeness;Cystic Fibrosis;cystic fibrosis patients;Data;Decision Making;Doctor of Philosophy;Education;Educational Activities;Educational workshop;Electronic Mail;Ensure;Environment;Epithelium;Expenditure;experience;Extramural Activities;Faculty;Faculty Recruitment;Feedback;flexibility;forging;Fostering;Foundations;Funding;gastrointestinal;Goals;gut dysbiosis;Health;high standard;Immune response;Immunity;improved;Individual;Infrastructure;innovation;Institution;Intellectual Property;Interdisciplinary Study;interest;Laboratories;Leadership;liver function;meetings;member;microbial colonization;microbial community;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;novel therapeutic intervention;Outcome;Patient-Focused Outcomes;peer;Performance;Pilot Projects;Probability;Process;Productivity;Program Development;programs;Progress Reports;quality assurance;recruit;Reporting;Research;Research Activity;research and development;Research Personnel;Research Project Grants;Research Support;Research Technics;Resources;Role;Rotation;Schedule;Series;Services;skills;social media;Structure;success;symposium;Technology Transfer;Therapeutic;Training Activity;Translating;translational pipeline;translational potential;Translational Research;Translations;United States National Institutes of Health;Validation;web site

PROJECT_TITLE: Enrichment and Research Administration Core


NIH_SPENDING_CATS: Biotechnology;Cystic Fibrosis;Digestive Diseases;Lung;Microbiome;Orphan Drug;Pediatric;Rare Diseases

PI_NAMEs: STANTON, BRUCE A. (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;3-Dimensional;Affect;Animal Experimentation;aspirate;Bacteria;Basic Science;Bioinformatics;Biological;Biological Assay;Biological Models;Biological Response Modifier Therapy;Biology;Biometry;Biopsy;Biostatistics Core;Cell Culture Techniques;Cell Line;Cell model;Cells;Cellular biology;Child;Clinical;Clinical Research;Coculture Techniques;Collaborations;Cystic Fibrosis;cystic fibrosis mouse;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Development;Doctor of Philosophy;Ecology;Educational process of instructing;Educational workshop;Electrophysiology (science);Engineering;experimental study;Faculty;Feces;Forskolin;Fostering;gastrointestinal;gastrointestinal bacteria;Gastrointestinal Diseases;gastrointestinal epithelium;Genomics;Gills;Goals;Gram-Negative Bacteria;gut dysbiosis;gut microbiome;Human;Immunology;In Vitro;Industry;industry partner;Innate Immune Response;Intestines;Ions;Kidney;Longevity;member;metabolomics;Methodology;Methods;Microbe;microbial;Microbiology;microbiome;Mission;Modeling;Molecular;Molecular Biology;monolayer;mouse model;Mus;Mutation;novel;novel therapeutics;Organ;organ on a chip;Organoids;pathogen;Permeability;personalized medicine;Pharmaceutical Preparations;Physiology;Pilot Projects;Probiotics;professor;programs;protein transport;Publishing;Quantitative Reverse Transcriptase PCR;Reagent;Research;Research Personnel;Resistance;Science;Scientist;Services;single-cell RNA sequencing;Swelling;System;systemic inflammatory response;Techniques;Testing;Therapeutic;Tissue Sample;Tissues;tool;tool development;Training;transcriptome sequencing;Transfection;Translational Research;Universities;Work

PROJECT_TITLE: Gastrointestinal Biology Core


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Damage to the mammalian retina through injury or disease causes irreversible vision loss, unlike in other vertebrates, which restore tissue function through Müller glia-based regeneration. I propose to overexpress a robust cell reprogramming factor, L-Myc, in murine Müller glia in retinal tissue to understand the capacity of these cells to change cell state in an injury model. The results of this study will provide insight on what genetic signals are sufficient to induce cell state changes in mammalian Müller glia, what signals are inhibitory to this process, and ultimately identify targets for future genetic therapies to restore vision after injury.

PI_NAMEs: STONE, MEGAN  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adult;Affect;Alleles;ATAC-seq;BHLH Protein;Binding;bioinformatics network;Biological Process;Blindness;Bromodeoxyuridine;Cell Cycle;Cell division;cell growth;Cell Reprogramming;cell type;Cells;Chromatin;Color;Competence;Data;data integration;design;Disease;DNA;Electroporation;Euchromatin;Family;Fibroblasts;Fishes;Fluorescence;fluorophore;functional restoration;Future;Gene Expression;Gene Expression Regulation;gene regulatory network;gene therapy;Genes;Genetic;Genetic Transcription;Heritability;Histone H3;Histones;Hour;In Vitro;induced pluripotent stem cell;Injury;insight;Label;Mammals;Measures;Modeling;mouse model;Muller's cell;Multiomic Data;Mus;MYCL1 gene;Natural regeneration;Neuroglia;Neurons;Ontology;Orthologous Gene;overexpression;Pattern;Plasmids;Play;Population;prevent;Process;progenitor;programs;Proliferating;Proteins;Regenerative capacity;response;response to injury;restoration;Retina;retinal neuron;retinal progenitor cell;retinal regeneration;Role;selective expression;sight restoration;Signal Transduction;Somatic Cell;Sorting;Source;Stains;stem cells;System;teleost fish;Testing;Time;tissue regeneration;Tissue-Specific Gene Expression;Tissues;transcriptome sequencing;transcriptomics;vector;Vertebrates;Vision;Visual;Visual impairment;Zebrafish

PROJECT_TITLE: Reprogramming adult murine Müller glia via L-Myc expression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Lung;Rare Diseases

PI_NAMEs: HOGAN, DEBORAH A (contact)

PROJECT_TERMS: Archives;Area;aspirate;Basic Science;biobank;Biological Assay;Biopsy;Body System;Caring;Cells;Clinical;clinical care;clinical center;Clinical Research;Collaborations;Collection;Communities;Complement;Consent;Cross-Sectional Studies;Cystic Fibrosis;cystic fibrosis patients;Data;design;Development;dietary;Discipline;Disease;DNA;Enrollment;Feces;Funding;gastrointestinal;Gastrointestinal tract structure;Goals;gut microbiota;Health;Health Status;Heterogeneity;Home;human subject;Immune;implementation facilitation;improved;inflammatory marker;Informed Consent;Inpatients;insight;Institution;Institutional Review Boards;Intestines;Investigator-Initiated Research;Laboratories;Longitudinal Studies;Lung;Measures;member;Metabolic;method development;Methods;Mission;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;novel therapeutics;Office Visits;Organ;Outcome;patient population;Patients;Physicians;Pilot Projects;Population;Preparation;Process;Prospective Studies;Proteins;Protocols documentation;Pulmonary Cystic Fibrosis;Quality Control;Recording of previous events;Records;Rectum;Research;Research Design;Research Personnel;Research Project Grants;research study;Research Support;Resources;RNA;RNA analysis;sample collection;Sampling;Sampling Studies;Schedule;Scientist;Serum;Site;Specimen;stool sample;success;Surveys;System;Testing;Time;Translational Research;treatment effect;treatment response;Urine;Visit;Whole Blood;Work

PROJECT_TITLE: Clinical and Translational Research Core


NIH_SPENDING_CATS: Biotechnology;Cystic Fibrosis;Data Science;Genetics;Human Genome;Lung;Microbiome;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases

PROJECT_TERMS: Applications Grants;Area;Big Data;Bioinformatics;Biological;Biology;biomedical data science;Biomedical Research;Biometry;Biostatistics Core;Collaborations;Communication;Communities;community center;Complex;complex data;Computer software;Core Facility;Cystic Fibrosis;cystic fibrosis patients;cystic fibrosis related diabetes;Data;Data Analyses;data interoperability;data repository;Data Science;Data Scientist;Data Set;data sharing;data submission;Databases;Deposition;design;Development;Education;Educational process of instructing;Educational workshop;Ensure;experience;Experimental Designs;experimental study;Faculty;FAIR principles;follow-up;Foundations;Funding;Genomics;Goals;gut dysbiosis;Health;high dimensionality;high throughput analysis;host-microbe interactions;Hour;Human Resources;improved;Informatics;informatics tool;innovation;Institution;Instruction;instructor;interest;Investments;Language;large datasets;Lead;Learning;lectures;Life Cycle Stages;Manuscripts;meetings;metabolomics;Metagenomics;microbiome;Mining;Mission;Modeling;open data;outreach;Participant;patient registry;pediatric gut microbiome;peer;Positioning Attribute;Preparation;Productivity;Programming Languages;programs;Proteomics;public database;Published Comment;Randomized;Recording of previous events;Reporting;Reproducibility;Reproducibility of Results;Research;Research Design;Research Personnel;response;Sample Size;Scientist;Services;single cell analysis;single-cell RNA sequencing;skills;software systems;Source;Specialist;Statistical Computing;Students;System;Techniques;Text;Tissues;tool;Training;training opportunity;transcriptome sequencing;transcriptomics;Vision;Work;Writing

PROJECT_TITLE: CF Bioinformatics and Biostatistics Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative:  Autism Spectrum Disorders (ASD) affect 1 in 60 children in the United States. Despite its prevalence, the aberrations in neuronal development that lead ASDs are not well understood. This study focuses on understanding how patient mutations in genes involved in translation result in ASDs and what cellular pathways are dysregulated as result of these mutations.

PI_NAMEs: MOHAMED, MUHANED  (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Actins;Affect;Alleles;Amino Acyl Transfer RNA;Astrocytes;autism spectrum disorder;Behavior;Biological Assay;Brain;Cell Line;Cell Separation;Cells;Child;Coculture Techniques;Complex;CRISPR/Cas technology;Cytoskeleton;Defect;density;Development;Diagnosis;Disease;Dominant-Negative Mutation;EEF1A1 gene;EEF1A2 gene;Electrophysiology (science);Elongation Factor;Epilepsy;excitatory neuron;Exhibits;experimental study;Fragile X Syndrome;Freezing;Frequencies;Functional disorder;gain of function;Gait abnormality;Genes;Genetic;genetic variant;Guanosine Triphosphate;Heart;Heterozygote;Human;Impairment;Induced Neurons;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;inhibitor;insight;Intellectual functioning disability;interest;Knock-out;Lead;Learning;live cell imaging;Location;Measures;Memory;Messenger RNA;Microtubules;migration;Missense Mutation;Modeling;Morphology;motor neuron degeneration;mouse model;Mus;Muscle;Muscle Cells;muscle form;Muscular Atrophy;mutant;Mutate;Mutation;Nerve Degeneration;neurite growth;Neurites;neurodevelopment;Neurodevelopmental Disorder;neuron development;neuronal cell body;neuronal survival;Neurons;patch clamp;Pathologic;Pathway interactions;Patients;Peptide Elongation Factor 1;Phenotype;Play;postsynaptic;Prevalence;Process;progenitor;Protein Biosynthesis;Protein Isoforms;Proteins;Regulation;repetitive behavior;Research;ribosome profiling;Ribosomes;Role;Shapes;Signal Pathway;Site;Social Behavior;social communication;Stains;Synapsins;synaptic function;synaptogenesis;System;Tissues;transcription factor;Transfection;Translating;Translations;translatome;Tremor;Tuberous Sclerosis;United States;Variant;Vertebral column;wasting;Weaning

PROJECT_TITLE: Functional Characterization of ASD-Associated EEF1A2 Mutations in Human Neurons


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE Despite the emerging link between air pollution exposure – specifically PM2.5 – and heighted risk of adolescent anxiety, the neurobehavioral mechanisms underlying this association are unknown. The proposed F32 project will be the first to evaluate whether exposure to recent PM2.5 concentrations is associated with poorer extinction recall, lower frontolimbic activation, and higher anxiety symptoms during adolescence, a period of frontolimbic development and psychiatric vulnerability. This project will be an important first step towards identifying mechanisms underlying environmental risk of psychopathology and will lay a critical foundation for early interventions to stem the etiology of anxiety in at-risk pollution-exposed youth.

PI_NAMEs: ZUNDEL, CLARA  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Accounting;Adolescence;Adolescent;Adult;Affect;Age;Air Pollutants;Air Pollution;Animals;Anxiety;Anxiety Disorders;anxiety symptoms;anxiety treatment;Asthma;Biological Markers;blood-brain barrier permeabilization;Brain;Brain region;career;Central Nervous System;Child;Childhood;childhood anxiety;Chronic Disease;Cognitive Therapy;cohort;conditioned fear;Coupled;Data;Development;Diameter;early adolescence;Early Intervention;early onset;Education;Environmental Exposure;Environmental Health;Environmental Impact;Environmental Risk Factor;Etiology;Evidence based treatment;Exhibits;experimental study;Exposure to;Extinction;Fellowship;Female;fine particles;Foundations;Fright;Functional disorder;Functional Magnetic Resonance Imaging;Galvanic Skin Response;Graph;Health;Height;Hippocampus;Hour;Human;imaging study;Impairment;interest;Interruption;Intervention;Learning;learning extinction;Link;Literature;Lung;Malignant Childhood Neoplasm;Measurement;Measures;Mental disorders;Mental Health;Mentors;Modeling;National Institute of Mental Health;neural;neural circuit;neurobehavioral;Neurobiology;neuroimaging;neuroinflammation;neuropsychiatric disorder;neurotoxic;Neurotoxins;novel;Obesity;Outcome;Participant;Particulate Matter;Pathway interactions;Penetration;Physiological;Pollution;pre-clinical;Predisposition;Prefrontal Cortex;Prevalence;Psychopathology;Psychophysiology;Recording of previous events;recruit;Regulation;Reporting;Research;Research Infrastructure;Resolution;response;Risk;Role;Severities;Socioeconomic Factors;spatiotemporal;stem;Structure;systematic review;systemic inflammatory response;Testing;Therapeutic;Toxic Environmental Substances;Training;Training and Infrastructure;training project;traumatic stress;treatment of anxiety disorders;treatment response;Underachievement;virtual reality;Work;Youth

PROJECT_TITLE: Impact of ambient PM2.5 concentrations on fear extinction recall, frontolimbic circuitry, and anxiety in adolescents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Stroke;Traumatic Head and Spine Injury

ORG_CITY: CHICAGO

ORG_NAME: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB

ORG_STATE: IL

PHR: Project Narrative Restoration of community mobility is a goal for most of the 7.2 million stroke survivors in the US, who experience chronic gait impairments due to spasticity, contractures, and muscle weakness. Available therapies that focus on stimulation of affected ipsilateral and contralateral areas of the brain are not effective in the long term. Noninvasive electrical stimulation of the spinal cord, in combination with symmetry-focused gait training, may facilitate short-term or long-term modulation of spinal circuitry to improve walking function, and thus health and quality of life, in persons with chronic stroke.

PI_NAMEs: JAYARAMAN, ARUN  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: actigraphy;Acute;Address;Affect;Age;Animal Model;Area;Axon;Biomechanics;Brain;Cervical spinal cord structure;Chronic;chronic stroke;Clinical;Clinical Trials;Communities;Contracture;Contralateral;Data;Dose;Educational Intervention;Effectiveness;Electric Stimulation;Electromyography;Electrophysiology (science);Energy Metabolism;experience;experimental study;Functional disorder;Gait;Gait abnormality;gait rehabilitation;Gait speed;gait symmetry;Goals;H-Reflex;Health;Health Status;Heart Rate;Hemiplegia;Human;Impairment;improved;Individual;Intervention;Ipsilateral;kinematics;Length;Long-Term Effects;Lower Extremity;Lumbar spinal cord structure;Measures;Mental Depression;meter;Methods;Motor;Motor Activity;motor control;Motor Cortex;Motor Evoked Potentials;motor impairment;Motor Neurons;Movement;Muscle;Muscle Weakness;Neural Pathways;Neuroanatomy;Neurologic;neuroregulation;Neurostimulation procedures of spinal cord tissue;noninvasive brain stimulation;Outcome Measure;Paresis;Participant;Pathway interactions;Pattern;Performance;Peripheral;Persons;physical therapist;Physiological;placebo group;post stroke;preservation;primary outcome;Protocols documentation;Publishing;Quality of life;Randomized;randomized, clinical trials;Recovery of Function;Rehabilitation therapy;remediation;Research;response;restoration;secondary outcome;Side;Site;spasticity;spatiotemporal;Speed;Spinal;Spinal Cord;Spinal cord injury;spinal pathway;spinal reflex;Stroke;stroke model;stroke patient;stroke survivor;System;targeted treatment;Techniques;Testing;Therapeutic;Time;tool;Training;Transcranial magnetic stimulation;Transcutaneous Electric Nerve Stimulation;treadmill;treatment site;Upper Extremity;Vertebral column;Walking;walking speed;Wallerian Degeneration;wearable sensor technology;Work

PROJECT_TITLE: Locomotor function following transcutaneous electrical spinal cord stimulation in individuals with hemiplegic stroke

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Human Genome;Lupus;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative 90% of individuals with systemic lupus erythematosus (SLE) are women, but the mechanisms that underly this sex bias are poorly understood. Mounting evidence suggests that perturbed X chromosome inactivation (XCI) maintenance in lymphocytes may contribute to the development of female-biased autoimmune disease. This project aims to investigate genetic and epigenetic features of XCI in age-associated B cells, an important cell type in SLE pathogenesis, and to leverage a novel mouse model of B-cell specific disrupted XCI maintenance to determine how contributions from the X chromosome in B cells underly sex biased autoimmune disease.

PI_NAMEs: LOVELL, CLAUDIA DARNELL (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: age related;Alleles;Antibodies;Autoantibodies;Autoimmune Diseases;Autoimmunity;B cell differentiation;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Biological Assay;Breeding;Cell Compartmentation;Cell Physiology;cell type;Cells;Cellular biology;Characteristics;Chemicals;Complex;Data;Deposition;Development;Diagnosis;Disease;Disproportionately impacts women;dosage;Dosage Compensation (Genetics);ds-DNA;Endosomes;Epigenetic Process;experimental study;Female;Gene Dosage;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Transcription;Height;Histones;Human;Immune;immunoregulation;Impairment;improved;in vitro Assay;Individual;Injections;insight;Klinefelter's Syndrome;Laboratory Finding;Link;Lymphocyte;Maintenance;Mammals;Mediating;member;men;Modeling;mouse model;Mus;novel;Pathogenesis;Pathway interactions;Persons;Phenotype;Play;Population;Predisposition;Pristane;Production;Proliferating;recruit;Regulator Genes;Research Proposals;response;risk variant;RNA;Role;Sex Bias;Signal Transduction;Somatic Cell;Stimulus;Systemic Lupus Erythematosus;Testing;Time;TLR7 gene;transcriptome sequencing;Untranslated RNA;Up-Regulation;Visualization;Woman;women patients;X Chromosome;X Inactivation

PROJECT_TITLE: Defining the Role of Dynamic X Chromosome Inactivation in Age-Associated B Cells for Female-Biased Systemic Lupus Erythematosus


NIH_SPENDING_CATS: Cystic Fibrosis;Lung;Microbiome;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: O'TOOLE, GEORGE A. (contact)

PROJECT_TERMS: Applications Grants;Area;Award;base;Basic Science;Bioinformatics;Biology;Biostatistics Core;Blood;Centers of Research Excellence;Climate;clinical application;clinical center;Clinical Research;Clinical Sciences;clinically relevant;Collaborations;Communities;Crystallization;Cystic Fibrosis;cystic fibrosis related diabetes;Data;design;Development;Disease;Doctor of Philosophy;experience;Extramural Activities;Faculty;faculty mentor;Faculty Recruitment;faculty support;Feces;Fostering;Foundations;Funding;Funding Opportunities;gastrointestinal epithelium;Goals;Grant;Growth;gut dysbiosis;Health;Heart;host-microbe interactions;Individual;Infection;innovation;Institution;Institutional Review Boards;Interdisciplinary Study;interest;Intestines;Label;large datasets;Leadership;Liver;Lung;member;Mentors;Microbe;microbial community;microbiome analysis;Mission;Modeling;Mucous body substance;National Institute of Diabetes and Digestive and Kidney Diseases;Nursing Research;Patients;Physicians;Pilot Projects;Play;pre-clinical;Preparation;Procedures;Productivity;Program Development;Program Research Project Grants;programs;Publications;Reagent;recruit;Regulation;Request for Applications;Research;research and development;Research Design;Research Personnel;Research Project Grants;Research Proposals;Research Support;Resources;Role;Sampling;Scientist;senior faculty;stem;Stimulus;success;Systemic disease;systemic inflammatory response;Teacher Professional Development;Tissues;tool;transcriptome sequencing;Translational Research;translational study;United States National Institutes of Health;Urine;Work

PROJECT_TITLE: Pilot Project Program


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Food Allergies;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

ORG_STATE: MA

PHR: PROJECT NARRATIVE The sex difference in the profile of extracellular bioactive lipids, which mediate the progression and resolution of inflammation, is linked to the sex-dependent differential cellular response, and incidence and severity of various diseases. Our proposal will investigate the sex differences during histamine-mediated ocular allergic inflammation in cellular response of conjunctival goblet cells and the differential profile of extracellular proinflammatory and specialized pro-resolving lipid mediators that are secreted via extracellular vesicles . Our study will provide new insights into the lipid-mediated ocular surface protection mechanism regulated by the conjunctiva, which has been consistently under-studied.

PI_NAMEs: LEE, CHANGRIM  (contact)

PROJECT_TERMS: Affect;Allergens;Allergic;Allergic inflammation;allergic response;Allergic rhinitis;American;Anabolism;Anterior eyeball segment structure;Asthma;Cell secretion;Cells;comorbidity;comparison control;conjunctiva;Conjunctival Epithelium;Cornea;Data;Dinoprostone;Disease;Eczema;Enzyme Activation;Enzymes;Eosinophilic Esophagitis;Epithelial Cells;Event;extracellular;Extracellular Space;extracellular vesicles;Eyelid structure;Female;Food Hypersensitivity;Goblet Cells;Health;Histamine;Histamine Release;Homeostasis;Human;human female;Hypersensitivity;Incidence;Inflammation;Inflammation Mediators;Inflammatory;insight;Leukotriene B4;Life;Link;lipid mediator;Lipids;lipoxin A4;LOX gene;male;MAPK3 gene;mast cell;Measures;Mediating;Mediator;Molecular;Mucins;novel;ocular surface;ocular surface disease;Phosphorylation;Phosphotransferases;Population;Prevalence;programmed cell death protein 1;PTGS2 gene;Publications;Reaction;Research;Research Proposals;Resolution;response;Role;Sclera;Severities;sex;Sex Differences;success;Testing;Therapeutic;Time;Tissues;Vision;Visual

PROJECT_TITLE: Sex difference in conjunctival epithelial cell response and their profile of extracellular bioactive lipids duringallergic inflammation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;HIV/AIDS;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative Despite widespread use of antiretroviral (ARV) therapy, approximately half of people living with HIV exhibit symptoms of HIV-Associated Neurocognitive disorder, a hallmark of which is the atrophy of white matter and the loss of myelin. We have previously demonstrated that select ARV drugs inhibit maturation and differentiation of oligodendrocytes, the cells responsible for myelination in the CNS. The proposed experiments aim to elucidate the role that stress granules play in the inhibition of maturation in ARV treated oligodendrocytes, so as to better understand the mechanisms of oligodendrocyte dysfunction as a prelude to designing therapies.

PI_NAMEs: VON KRUSENSTIERN, ELIANA VERA (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acceleration;Acute;Address;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Anti-Retroviral Agents;antiretroviral therapy;arm;Atrophic;attenuation;Autopsy;Axon;Behavioral;biological adaptation to stress;Cell Death;cell type;Cells;Chronic stress;Clinical;Complex;Cytoplasm;Cytoplasmic Granules;Data;Drug Exposure;Eukaryotic Cell;Exhibits;experience;experimental study;Exposure to;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;G3BP1 gene;Genes;HIV;HIV-associated neurocognitive disorder;Homeostasis;improved outcome;Inhibition of Apoptosis;inhibitor;insight;Integrase;Investigation;Knock-out;Lipids;Measures;Mediating;Membrane;Messenger RNA;motor deficit;Myelin;myelination;Nerve Degeneration;Nervous System Disorder;Neurocognitive;Neurocognitive Deficit;Neurodegenerative Disorders;Neurons;oligodendrocyte myelination;Oligodendroglia;Organelles;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Play;preservation;prevent;Process;Protein Biosynthesis;Protein Kinase;Proteins;Research;retroviral-mediated;RNA-Binding Proteins;Role;Stress;stress granule;stressor;Symptoms;Testing;therapy design;transcriptome;Translational Repression;Translations;treatment response;United States;Viral;Viral Load result;white matter;Work

PROJECT_TITLE: Stress Granule Formation in the Antiretroviral-Mediated Dysregulation of Oligodendrocyte Maturation in HIV-HAND


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biomedical Imaging;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Completion of this project will outline the function of an evolutionarily conserved set of ciliary proteins that are essential for embryonic development. This proposed work will study whole embryo, cellular, and membrane biochemistry of ciliary proteins to further our understanding of congenital craniofacial disorders.

PI_NAMEs: VAZQUEZ, NEFTALI  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: 3-Dimensional;Affect;Alleles;Animal Model;Binding;Biochemical;Biochemistry;Biological Assay;Body System;Cell membrane;Cell Physiology;Cells;Cellular biology;Cephalic;Cilia;ciliopathy;cilium biogenesis;Cilium Microtubule;Congenital Disorders;craniofacial;craniofacial development;craniofacial disorder;craniofacial structure;Data;Development;Disease;Docking;Dysmorphology;Embryo;Embryonic Development;Etiology;Face;Functional disorder;Gene Expression Profiling;Genes;genetic variant;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Hamartoma;Head;Homeostasis;Human;human embryonic development;Image;In Vitro;in vitro Assay;in vivo;in vivo imaging;insight;kinetosome;knock-down;Left;Letters;Link;Lipid Binding;Lipid Biochemistry;Lipids;Maps;Mediating;Membrane;Membrane Biology;microCT;Molecular;Morphology;Mutation;Neural Crest;neuroregulation;Orofaciodigital Syndromes;Palate;Patients;Phenotype;Play;Proliferating;protein complex;protein function;Proteins;Proteomics;Public Health;Research;Role;Structural defect;Structure;superresolution microscopy;System;Testing;Tongue;Vesicle;Work;Xenopus

PROJECT_TITLE: Investigating craniofacial phenotypes, cellular function, and membrane biochemistry of ciliary proteins Rsg1 and the Fam92-Chibby-Dzip module

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Autism spectrum disorders (ASDs) are associated with cognitive deficits in perception, social interaction, and communication, and recent evidence suggests that the disruption of GABAergic inhibitory function is a likely mechanism underlying ASDs. One major challenge in exploring GABAergic dysfunction is the diversity of inhibitory interneurons, which can be subdivided into distinct classes with different physiology, synaptic targets, and molecular markers, and thus, will each have a unique contribution to ASD symptoms. This proposal will disrupt the expression of an ASD-linked gene in parvalbumin-expressing inhibitory interneurons to gain mechanistic insights into how impaired parvalbumin interneuron dysfunction can contribute toward ASD symptoms.

PI_NAMEs: WARD, CLAIRE  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Address;Affect;Age;age related;ASD patient;autism spectrum disorder;autism symptoms;Autopsy;Behavior;behavioral phenotyping;Brain;brain tissue;Candidate Disease Gene;cell type;Cells;Cerebral cortex;Characteristics;Cognition;Cognitive deficits;Communication;Development;Electrophysiology (science);Epilepsy;Excision;excitatory neuron;Functional disorder;GABA Receptor;gamma-Aminobutyric Acid;Genes;Genetic study;Genetic Transcription;Genomics;Goals;Histologic;Histology;Human;Impaired cognition;Impairment;in vitro activity;in vivo;individuals with autism spectrum disorder;inhibitory neuron;insight;Interneuron function;Interneurons;Link;Mediating;Missense Mutation;model of autism spectrum disorder;Molecular;molecular marker;mouse genetics;mouse model;Mus;Myoepithelial cell;neural network;Neurons;novel;Parvalbumins;Patients;Pattern;Perception;Physiology;Play;prevent;receptor expression;Regulation;Reporting;Role;Runaway;Sensory;Shapes;Signal Transduction;Slice;Social Interaction;Synapses;synaptic function;Synaptic Transmission;Testing;transcription factor;transcriptomics;Visual Cortex

PROJECT_TITLE: Developmental Dysfunction of Parvalbumin Interneurons in Autism Spectrum Disorder


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

ORG_CITY: Aurora

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Unhealthy alcohol use negatively impacts the entire continuum of HIV prevention and treatment but is challenging to diagnose since self-report consistently under-represents actual alcohol consumption. This project will leverage existing samples and data from two seminal trials of injectable long-acting vs. oral antiretroviral therapy to evaluate the predictive power of an objective alcohol biomarker (PEth) for clinical outcomes in persons at risk for HIV, and persons with HIV with the highest potential to transmit to others. In parallel to establishing these relationships, a point-of-care test will be developed to measure PEth in the clinic, enabling real time interventions to reduce alcohol consumption and prevent acquiring or transmitting HIV.

PI_NAMEs: BROOKS, KRISTINA MARIE (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Acceleration;Adherence;AIDS clinical trial group;AIDS prevention;Alcohol consumption;alcohol misuse;Alcohols;Aliquot;antiretroviral therapy;Biological Assay;Biological Markers;Blood;blood glucose regulation;Blood specimen;Clinic;Clinical;clinical care;cohort;Colorado;Data;Dedications;Diagnosis;Diphosphates;Dose;Double-Blind Method;Dropout;Dryness;economic incentive;emtricitabine;Epidemic;Erythrocytes;Ethanol;experience;Failure;Fumarates;Glycosylated hemoglobin A;Half-Life;HIV;Individual;Injectable;Injections;Intervention;Knowledge;Laboratories;mass spectrometer;Measures;men;Modernization;Oral;Outcome;Participant;Patient Self-Report;Persons;Pharmaceutical Preparations;phosphatidylethanol;Phospholipids;Placebos;point of care;point of care testing;Population;Populations at Risk;pre-exposure prophylaxis;prevent;Random Allocation;Randomized;randomized trial;Recording of previous events;recruit;Resources;Risk;Sampling;Seminal;Shapes;Spottings;Tenofovir;Testing;Time;transgender women who have sex with men;Translating;transmission process;trial comparing;Universities;Validation;Viral;Virus Replication;Whole Blood;Work

PROJECT_TITLE: Predictive Power of PEth for HIV Prevention in the Long-Acting Era


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Skin Cancer

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative: Skin disease affects 1 in 4 Americans, and doctors base diagnosis and management decisions on changes in skin appearance. But visual markers of disease can be indirect and subjective, especially in skin of color patients where skin changes like redness are harder to see. We propose new infrared imaging technology that allows skin disease to be more objectively measured at both large and microscopic scales.

PI_NAMEs: SHMUYLOVICH, LEONID  (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: absorption;accurate diagnosis;Address;Adult;Affect;American;Appearance;Appointment;Award;Axilla;base;Benign;Biopsy;career;catalyst;Cessation of life;Child;chromophore;Chronic;chronic inflammatory skin;Cicatrix;clinic ready;Clinical;clinical training;Communities;cost;Coupled;Cutaneous;Data;Dedications;Dermatologist;Dermatology;detector;Devices;Diagnosis;Diagnostic;Disease;Disease Marker;Disease Progression;Disparity;Engineering;Ensure;Epidermis;Exclusion;experience;Face;Furuncles;Future;Grant;Hemoglobin;Hidradenitis Suppurativa;Histologic;Histology;HRK gene;Human;human subject;Image;imaging modality;Imaging technology;improved;in vivo;Inflammation;Inflammatory;Inguinal region;Institution;Joints;Lead;Leadership;Length;Lesion;Light;light scattering;Limb structure;Lipids;Malignant - descriptor;Measures;medical schools;Medicine;Melanins;Mentors;meter;Methods;Microscopic;microscopic imaging;Modality;Nature;Neoplasms;Neoplastic skin;new technology;non-invasive imaging;noninvasive diagnosis;novel;optical imaging;Optics;Patients;Penetration;people of color;Photography;Physicians;Physiological;Pilot Projects;Population;Positioning Attribute;pre-clinical;Procedures;Process;Productivity;professor;Psoriasis;Publishing;Radiology Specialty;Redness;reflectance confocal microscopy;Research;Research Personnel;Running;Scalp structure;Scientist;Severity of illness;Short Waves;Shortwave Infrared Imaging;Silicon;Skin;skin biopsy;Skin Cancer;skin color;skin disorder;Skin Pigmentation;Skin Tissue;Source;Standardization;success;System;Technical Expertise;Technology;tenure track;Testing;tissue phantom;Tissues;Training;Translating;Treatment outcome;Universities;Validation;virtual;Vision;Visual;Visualization;Washington;Water;Work

PROJECT_TITLE: Infrared Skin Imaging to Transform Noninvasive Diagnosis and Management of Skin Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE This study will determine whether there is a significant association between neighborhood characteristics, substance abuse, and mental health symptoms among urban youth. Using innovative methods in recruitment such as venue-based sampling, this study will obtain a representative sample of youth to include those who are most at-risk such as street- involved and truant youth. Results from this study will advance the field of substance abuse prevention by including hidden populations of youth to inform the adaptation of a substance abuse prevention intervention.

PI_NAMEs: OPARA, IJEOMA  (contact)

PROJECT_TERMS: Accounting;Address;Administrator;Adolescent;adolescent substance use;Adult;African American;Age;aged;AIDS prevention;anxiety symptoms;Area;Award;Behavioral Sciences;Black race;career;Characteristics;Cities;Clinical Trials;Collaborations;Communities;Community based prevention;community collaboration;community organizations;community partners;Complex;Data;Dedications;Dentistry;depressive symptoms;design;Development;Discipline of Nursing;Disparity;doctoral student;Drug abuse;Drug usage;Empirical Research;Environment;Epidemic;Equation;Ethnic Population;Evaluation;evidence base;experience;Exposure to;Faculty;feasibility trial;Focus Groups;Foundations;Gender;gender difference;Grant;health management;Health Sciences;Health Technology;Hepatitis C virus;Hispanic;HIV;Illicit Drugs;improved outcome;Individual;innovation;Institution;interdisciplinary approach;interest;Intervention;Literature;Manuscripts;Medicine;Mental Health;Mentors;Methodology;Methods;Modeling;multiple data sources;National Institute of Drug Abuse;Needs Assessment;Neighborhoods;New Jersey;New York;Outcome;Participant;Pharmaceutical Preparations;Phase;poor health outcome;Population;Populations at Risk;pre-doctoral;Prevention Research;preventive intervention;Process;programs;protective factors;Public Health;Publishing;Qualifying;Qualitative Methods;Race;racial population;recruit;Regression Analysis;Research;Research Personnel;research study;Research Support;Resource-limited setting;Resources;Risk;Risk Factors;risk perception;Role;Sampling;school district;Schools;Social Welfare;Socioeconomic Status;Structure;substance abuse prevention;Substance abuse problem;substance use;substance use prevention;suburban communities;Symptoms;Technology;Training;trend;Truancy;United States;Universities;Urban Community;Vulnerable Populations;Writing;Youth

PROJECT_TITLE: Understanding the Role of Neighborhoods on Urban Youth's Substance Use and Mental Health:  A Community-Based Substance Abuse Prevention Project


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative Mechanical forces generated by cells in epithelial tissue sheets play key roles in the development of functional tissues and organs. This project will integrate nanoengineering and optogenetic techniques to measure and manipulate these forces in order to better understand how tissues are shaped during development. Dysregulated forces in tissues can lead to disease states including birth defects, metastatic cancer, and improper wound healing and this project will shed new light on how mechanical forces contribute to human health and disease.

PI_NAMEs: CUPO, CHRISTIAN MICHAEL (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: 3-Dimensional;Actomyosin;Affect;Automobile Driving;Behavior;Cell Shape;Cells;Complex;Congenital Abnormality;convergent extension;Cultured Cells;Cytoskeleton;density;Development;Developmental Cell Biology;Disease;Disseminated Malignant Neoplasm;Drosophila genus;Drosophila melanogaster;Elasticity;Embryo;Engineering;Environment;Epithelial Cells;Epithelium;Event;flexibility;fluidity;Generations;Goals;graphene;Health;Human;improved;In Vitro;in vivo;Intercalated Cell;Intercellular Junctions;Length;Liquid substance;Malignant Neoplasms;Measurement;Measures;mechanical force;Mechanics;monolayer;Morphogenesis;Movement;movie;Myosin ATPase;nano;nanoengineering;nanomaterials;Nanotechnology;new technology;Nonmuscle Myosin Type IIA;optogenetics;Organ;Pattern;Play;prevent;Property;reconstitution;Regenerative Medicine;Regulation;Resolution;Role;self organization;Shapes;Solid;spatiotemporal;Stretching;Structure;System;Techniques;Testing;tissue culture;Tissue Engineering;Tissues;tool;two-dimensional;wound healing

PROJECT_TITLE: Understanding and Controlling the Cellular Forces that Coordinate Epithelial Tissue Morphogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-U(20)L]