NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_DEPT: PATHOLOGY

PHR: Evidence is mounting that neuronal hyperexcitability during the progression of Alzheimer’s disease (AD), can initiate decades prior to canonical memory loss and associated neuropathology. This proposal will model the dynamic relationship between hyperexcitation/hyperarousal and protein build up of tau and amyloid to understand how selective brain areas, like the locus coeruleus, are impacted early in disease. It will also demonstrate how this can lead to hippocampal dysfunction causing cognitive loss and will attempt to reverse pathological phenotypes by treating proteostasis deficits and ameliorating early stage neuronal hyperexcitation.

PI_NAMEs: HUSSAINI, S. ABID  (contact);YU, HO WH

PROGRAM_OFFICER_NAME: THOMAS, CIBU PAUL

PROJECT_TERMS: Acceleration;Affect;age related decline;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;Area;Arousal;Autophagocytosis;Behavioral;Biochemical;Biological;Biological Markers;biomarker signature;Blood;Brain;Brain region;Cell Physiology;Cells;Cognition;Cognitive;cognitive function;computerized tools;Defect;Dementia;Disease;Disease Progression;disorder risk;Electrophysiology (science);entorhinal cortex;Event;Feedback;fighting;Functional disorder;functional restoration;Garbage;Genes;Genetic Transcription;Goals;Health;Hippocampus;Homeostasis;Hyperactivity;Impaired cognition;Impairment;improved;in vivo;Individual;insight;Intervention;Knock-in Mouse;Knowledge;Lead;Life Cycle Stages;life span;Link;locus ceruleus structure;Machine Learning;machine learning algorithm;Measurement;Measures;Memory;Memory impairment;Memory Loss;Methods;Modeling;Modification;Molecular;Molecular Target;Monitor;mouse model;Mus;Nerve Degeneration;network dysfunction;neural network;neuron loss;Neuronal Dysfunction;Neurons;neuropathology;Onset of illness;Pathogenesis;Pathologic;Pathology;Pathway interactions;Pattern;Persons;Phenotype;Population;predictive modeling;Predisposition;Process;Property;protein aggregation;protein expression;Proteins;proteostasis;proteostasis loss;Regulation;response;Rest;restoration;Role;Severity of illness;Signal Transduction;Site;Sleep disturbances;stressor;System;tau Proteins;Techniques;Testing;Therapeutic;Time;tool;Ubiquitin;young adult

PROJECT_TITLE: The role of neuronal hyperexcitability and proteostasis in Alzheimer's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Genetics;Human Genome;Physical Activity;Prevention

ORG_CITY: RICHLAND

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BATTELLE PACIFIC NORTHWEST LABORATORIES

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed research aims to provide a comprehensive map of the protein “molecular transducers” that transmit the health benefits of physical activity by applying high throughput proteomics technologies. This project will be accomplished by a team and facility with an excellent record of accomplishment in applying and developing advanced mass spectrometry-based workflows and pipelines for proteomics research for human health applications.

PI_NAMEs: ADKINS, JOSHUA N. (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Acceleration;Acetylation;Acute;Adipose tissue;Adult;Age;Animal Model;Animals;Bioinformatics;Biological;Biopsy Specimen;Blood;Categories;Chemicals;Chronic;Chronic Disease;Clinical;clinical center;cohort;Collaborations;Collection;Communication;Consensus;COVID-19 pandemic;Data;data exchange;data management;Data Set;data warehouse;Development;endurance exercise;epigenomics;ethnic diversity;Evaluation;Event;Exercise;exercise intervention;exercise training;Female;Funding;Genomics;health application;Health Benefit;Human;human tissue;Inbred F344 Rats;Individual;insight;Knowledge;Leadership;Lysine;male;Manuscripts;Maps;Mass Spectrum Analysis;Mediating;men;metabolomics;Modification;Molecular;molecular phenotype;Molecular Profiling;Multiomic Data;multiple omics;Muscle;Oxidation-Reduction;Oxygen;Participant;Phosphorylation;Physical activity;Physical Exercise;Physiological;Pilot Projects;Positioning Attribute;Post-Translational Protein Processing;pre-clinical;Prevention;Process;Productivity;protein expression;Proteins;Proteome;Proteomics;Protocols documentation;Publications;Publishing;Qualifying;quality assurance;Quality Control;racial diversity;Rattus;recruit;repository;Research;Research Personnel;resistance exercise;response;Rest;Sampling;Scientist;sedentary;Series;Signal Transduction;Site;Skeletal Muscle;subcutaneous;systematic biology;Technology;Time;Tissues;Training;transcriptomics;Transducers;transmission process;United States National Institutes of Health;Woman;Work;working group

PROJECT_TITLE: ProMoTr: A Proteomics Center for MoTrPAC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-A (51)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Patient Safety;Prevention;Primary Health Care;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Rural cancer survivors experience a higher risk of negative health outcomes and require coordinated care to address the many effects of cancer and its treatment. Primary care providers recognize the importance of providing high-quality, evidence-based survivorship care and are well-positioned to meet survivor needs, however, these needs are often unmet due to limitations in knowledge, lack of resources, and administrative demands. Practical strategies are needed to assist PCPs to improve cancer survivorship care and this proposal will test implementation strategies to optimize the adoption of evidence-based practices for cancer survivorship care in rural primary care settings.

PI_NAMEs: GREINER, K ALLEN (contact);KLEMP, JENNIFER ROSE

PROGRAM_OFFICER_NAME: ETON, DAVID T

PROJECT_TERMS: Address;Adoption;Adult;Affect;arm;attentional control;cancer diagnosis;Cancer Patient;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer therapy;care coordination;care delivery;care systems;Caring;Chronic Disease;Clinic;Clinical;Cluster randomized trial;Code;Colorectal Cancer;comorbidity;Comprehensive Health Care;cost;Cost Analysis;Decision Making;design;Diagnosis;Documentation;Education;Effectiveness of Interventions;effectiveness testing;Electronic Health Record;Emotional;Evaluation;evidence base;evidence based guidelines;Evidence based intervention;Evidence based practice;expectation;experience;Face;Failure;Farm;formative assessment;Geography;Goals;Guidelines;Health;health management;Health system;Healthcare Systems;high risk;implementation barriers;implementation science;implementation strategy;implementation tool;improved;Infrastructure;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Intervention;intervention delivery;Kansas;Knowledge;Long-Term Effects;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Managed Care;markov model;Measures;Medical;Mental Health Services;Methods;Modification;National Comprehensive Cancer Network;novel strategies;Oncology;Outcome;Patient Care;Patients;phrases;point of care;Population;Positioning Attribute;post implementation;Preventive care;Preventive service;Primary Care;primary care clinic;primary care patient;primary care practice;primary care provider;primary care setting;primary outcome;Process;programs;prostate cancer survivors;Provider;Quality-Adjusted Life Years;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Resources;Risk;Role;Rural;rural environment;rural residence;Screening for cancer;secondary outcome;success;Survivors;survivorship;System;team-based care;Testing;theories;three-arm study;tool;Training;treatment as usual;Treatment/Psychosocial Effects;Use Effectiveness;virtual;wellness visit;Work

PROJECT_TITLE: KanSurvive 2.0

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (J1)]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: New biomaterials are revolutionizing how therapies are delivered to the body, yet these technologies have not been widely used for improving vessel growth and muscle function in patients who have suffered a heart attack. This project addresses this gap and many challenges in the heart by advancing customized vessel growth and muscle therapies using biomaterials with the goals of improving the blood supply in the heart, adding new heart muscle cells, and improving electrical and mechanical function of the heart. Experiments to help us understand how changes in heart function happen in response to these new biomaterial therapies will increase our understanding of the critical design features of the therapies to advance translation to the clinic for improving patient health and quality of life.

PI_NAMEs: COULOMBE, KAREEN LK (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Acceleration;Acute myocardial infarction;Address;Alginates;American;Angiogenic Factor;Angiogenic Proteins;Angioplasty;Anti-Arrhythmia Agents;Arrhythmia;Attention;Beds;Biocompatible Materials;blood perfusion;Blood Vessels;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;cardiac tissue engineering;Cell Transplantation;Cells;Cessation of life;Chemicals;Clinic;Clinical Trials;Collagen;controlled release;Data;density;design;Development;Disease;Emergency Situation;Engineering;Engraftment;Etiology;experimental study;Fibrosis;Film;first-in-human;Functional Regeneration;Gel;Gene Expression;Goals;Growth;Growth Factor;Health;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;Heparin;holistic approach;Human Engineering;human induced pluripotent stem cells;Implant;implantation;improved;in vivo;Incidence;induced pluripotent stem cell derived cardiomyocytes;Infarction;Injury;innovative technologies;insight;Ischemia;Knowledge;Left;Mechanics;meetings;Metabolic;Modeling;mortality;Muscle;Muscle function;Myocardial;Myocardial Infarction;Myocardial Reperfusion;Myocardial tissue;Myocardium;Natural regeneration;novel;Patients;Perfusion;Positioning Attribute;pre-clinical;preservation;Proteins;Quality of life;Rattus;Recovery;reduce symptoms;regenerative approach;Regenerative Medicine;repair strategy;repaired;Research;response;revascularization;Risk;Role;serial imaging;Structure;Survivors;System;Technology;Testing;Therapeutic;therapeutic protein;Three-dimensional analysis;Time;Tissue Engineering;Tissue Preservation;Tissues;Translations;Transplantation;vascular bed;Vascular blood supply;Vascular regeneration;vascular tissue engineering;Vascularization;Vasculogenic;Ventricular;Ventricular Remodeling

PROJECT_TITLE: Interdependence of Post-MI Local Revascularization and Remuscularization by Engineered Human Myocardium on Cardiac Remodeling and Regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-C (02)]


NIH_SPENDING_CATS: Asthma;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Precision Medicine;Prevention

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Underdiagnosis and undertreatment is a major problem in childhood asthma management, especially in preschool-aged children. Current prognostic approaches using risk-score based tools have poor-to-modest accuracy, are impractical, and have limited evidence of efficacy in clinical settings and hence are not widely used in practice. This award will support the candidate’s training in how to apply novel biostatistical and machine learning methodologies to pre-existing electronic health records prognostic data to develop a childhood asthma passive digital marker that can provide a timely, accurate, user-centered, and scalable approach for childhood asthma prognosis at point of care to address existing barriers associated with the use of risk-score based tools.

PI_NAMEs: OWORA, ARTHUR HAMIE (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Active Learning;Address;Adult;Age;Algorithms;Asthma;Award;Biometry;Birth;Blinded;Blood Tests;career;Child;Childhood Asthma;Clinical;clinical decision support;clinical decision-making;clinical practice;Clinical Research;cohort;Data;design;Detection;Development;Diagnosis;digital;Digital biomarker;Disease;disorder risk;Early Diagnosis;Early treatment;effectiveness testing;efficacious intervention;efficacy evaluation;Electronic Health Record;Enrollment;Epidemiologist;Epidemiology;Evaluation;Evaluation Studies;experience;Fellowship;Future;Goals;Grant;Health;health information technology;implementation research;improved;Indiana;Individual;insight;Intervention;Intuition;Knowledge;Logistic Regressions;Machine Learning;machine learning algorithm;machine learning method;Medical;Medical History;Mentored Research Scientist Development Award;Mentors;Modeling;Morbidity - disease rate;Mothers;multidisciplinary;National Heart, Lung, and Blood Institute;Natural History;novel;Nursery Schools;Online Systems;Pathway interactions;Patient Care;Patient-Focused Outcomes;pediatrician;Performance;personalized care;personalized medicine;Phenotype;Physicians;point of care;Postdoctoral Fellow;Predictive Analytics;primary caregiver;Prognosis;prognostic;Prognostic Factor;prognostic signature;Proxy;Random Allocation;Randomized;randomized, clinical trials;Research;Risk;Sample Size;School-Age Population;Scientist;skills;Spirometry;support tools;Symptoms;Testing;Time;tool;Training;Training Activity;Translating;translational scientist;treatment choice;United States;United States National Institutes of Health;usability;Validation

PROJECT_TITLE: Developing a Childhood Asthma Risk Passive Digital Marker


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Physical Injury - Accidents and Adverse Effects

ORG_CITY: LA JOLLA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: NARRATIVE Rotator cuff tears are common, affecting over 20% of the general population, with a high incidence of retear after repair, ranging between 30% to 94%. Arthroscopic 3D bioprinting is a potential high impact medical treatment, where a tendon can be “spot welded” to the bone during repair to enhance healing and reduce the incidence of retear. The objective of this proposal is to develop an arthroscopic 3D bioprinter.

PI_NAMEs: BERRY, DAVID BARNES (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TITLE: An Arthroscopic 3D Bioprinter for Minimally Invasive Rotator Cuff Tear Repair

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Behavioral and Social Science;Physical Activity;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The Molecular Transducers of Physical Activity (MoTrPAC) project will define the molecular changes that occur during exercise and following exercise training. The identification of which molecules change with exercise and training may allow us to find ways to enhance or mimic the broad beneficial effects of exercise on a person’s health.

PI_NAMEs: BURANT, CHARLES F (contact);EVANS, CHARLES ROBERT;LI, JUN

PROJECT_TERMS: 18 year old;Acceleration;Acute;Adipose tissue;Adolescent;Adult;Age;Animal Model;Animals;biobank;Bioinformatics;Biomedical Research;Biopsy Specimen;Blood;Categories;Chemicals;Child;Childhood;Chromatography;Chronic;Clinical;clinical center;Clinical Data;clinical development;Clinical Research;cohort;Collaborations;Collection;Communities;computer scientist;Control Groups;Core Facility;cost effective;COVID-19 pandemic;Cross-Sectional Studies;Data;Data Analyses;data exchange;data integration;data warehouse;Elements;endurance exercise;Enrollment;epigenomics;ethnic diversity;Ethnic Origin;Event;Exercise;Exercise Test;exercise training;Female;Funding;Gender;General Population;Genomics;group intervention;Health;Health Benefit;Human;human data;Human Resources;human tissue;Inbred F344 Rats;Individual;insight;ionization;Ions;Knowledge;Lead;male;Manuscripts;Maps;meetings;member;men;metabolome;metabolomics;Michigan;Modality;Molecular;Molecular Biology;molecular phenotype;Molecular Profiling;Multiomic Data;multiple omics;Muscle;Names;novel;novel strategies;Oxygen;Participant;Persons;Phase;Phenotype;Physical activity;Physical Exercise;Physiological;Population;pre-clinical;preclinical study;Productivity;Proteomics;Protocols documentation;Publications;Qualifying;Race;racial diversity;Randomized;Rattus;recruit;Research Personnel;resistance exercise;response;Rest;reversed phase chromatography;sample collection;Sampling;Schedule;Scientist;sedentary;Series;Site;skeletal tissue;Steroids;Subgroup;systematic biology;Testing;Time;Tissues;Training;trait;transcriptomics;Transducers;United States National Institutes of Health;Universities;Woman;Work;working group;Writing

PROJECT_TITLE: Michigan MoTrPAC Chemical Analysis Site (MiCAS)


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Data Science;Genetics;Human Genome;Physical Activity;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative  Prolonged or intensive physical activity has a profound effect on the lipid profiles of a variety of organs and bodily fluids. Lipidomics technologies enable these lipid changes to be accurately mapped to yield a more complete scientific understanding of how exercise affect lipids as fuels, signaling messengers and structural molecules. We will continue to serve as the MoTrPAC Chemical Analysis Site devoted to both targeted and untargeted lipidomic studies using mass spectrometry technologies, and the associated data science and bioinformatic efforts to integrate the multiomic datasets being created by the Consortium.

PI_NAMEs: FERNANDEZ, FACUNDO MARTIN;ORTLUND, ERIC A (contact)

PROJECT_TERMS: 18 year old;Acceleration;Acute;Adipose tissue;Adult;Affect;Age;Animal Model;Animals;Big Data;Bioinformatics;Biopsy Specimen;Blood;Body Fluids;Categories;Chemicals;Childhood;Chronic;Clinical;clinical center;cohort;Collaborations;Communication;COVID-19 pandemic;Data;Data Analyses;data exchange;Data Science;Data Set;data warehouse;Elements;endurance exercise;epigenomics;ethnic diversity;Evaluation;Event;Exercise;exercise intervention;exercise training;Female;Funding;Genomics;Goals;Health Benefit;human tissue;Inbred F344 Rats;Knowledge;lipidome;lipidomics;Lipids;male;Manuscripts;Maps;Mass Spectrum Analysis;men;metabolomics;Molecular;molecular phenotype;Molecular Profiling;Multiomic Data;multiple omics;Muscle;Organ;Oxygen;Participant;Physical activity;Physical Exercise;Physiological;Population;pre-clinical;Productivity;Proteomics;Protocols documentation;Publications;Publishing;Qualifying;quality assurance;racial diversity;Rattus;recruit;Research Personnel;resistance exercise;Rest;Scientist;sedentary;Series;Signal Transduction;Site;System;systematic biology;Technology;Tissues;Training;transcriptomics;Transducers;United States National Institutes of Health;Woman;working group

PROJECT_TITLE: Georgia Comprehensive Metabolomics and Proteomics Unit for MoTrPAC


ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative While physical activity prevents or improves many diseases, the chemical changes that occur in the body and lead to better health are not well known. As a part of a consortium of physical activity research programs working together, we will use advanced technologies to comprehensively study the changes in genes and gene products caused by physical activity. This study can potentially lead to advances in preventing and treating many diseases using physical activity.

PI_NAMEs: SEALFON, STUART C. (contact);WALSH, MARTIN JOHN

PROJECT_TERMS: Abdomen;Acute;Adipose tissue;Adult;Alternative Splicing;animal data;Animals;Area;ATAC-seq;Bioinformatics;Biological;Biological Assay;Blood specimen;candidate identification;Cell Surface Receptors;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chemicals;Child;Chromatin;Chronic;Clinical;clinical center;Clinical Research;Clinical Trials;Collaborations;Communities;Cost efficiency;Data;Data Analyses;data pipeline;data quality;data resource;Databases;Development;Disease;Elements;endurance exercise;Ensure;epigenomics;Exercise;exercise intervention;exercise training;experience;fitness;Foundations;Funding;Gene Expression;gene product;Genes;Genetic;Genome;genome sequencing;genomic data;Genomics;Goals;Health;Health Benefit;Human;human data;human disease;improved;Individual;individual response;Infrastructure;insight;Journals;Knowledge;Manuscripts;Maps;medical schools;methylome;Molecular;Molecular Analysis;Molecular Target;Multiomic Data;multiple datasets;Muscle;New York;Observational Study;Organ;Pathway interactions;Pediatrics;Peer Review;phenotypic data;Physical activity;Physical Exercise;pre-clinical;preclinical study;predictive modeling;Preparation;prevent;Prevention;programs;Protocols documentation;public database;Publications;Randomized;Randomized, Controlled Trials;Rattus;Receptor Activation;Research Activity;resistance exercise;Resources;response;Role;Sampling;Scientist;sedentary;Site;success;Technology;Tissues;Training;transcriptome;transcriptome sequencing;transcriptomics;Transducers;United States National Institutes of Health;Universities;whole genome;Work

PROJECT_TITLE: MoTrPAC Genomics, Epigenomics and Transcriptomics Chemical Analysis Site


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections

ORG_CITY: NEW ORLEANS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: PROJECT NARRATIVE People living with human immunodeficiency virus (HIV) infection remain at increased risk of head and neck cancers due to human papillomavirus (HPV) infection, despite adequate management of their HIV with antiretroviral therapy (ART). This project explores the hypothesis that ART increases susceptibility to oral HPV infection by damaging the integrity of the oral mucosal tissue. Understanding if ART plays a role in enhancing risk of oral HPV infection is crucial to develop new intervention strategies to prevent HPV-mediated head and neck cancers in people living with HIV.

PI_NAMEs: CAMERON, JENNIFER ERIN (contact);HAGENSEE, MICHAEL E;MEYERS, CRAIG M

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: 3-Dimensional;Adherens Junction;Adverse effects;AIDS prevention;antiretroviral therapy;Architecture;Biopsy;CD4 Positive T Lymphocytes;Cell Line;Cells;Clinical;Clinical Management;Clinical Research;Data;Desmosomes;Disease;Drops;Epithelium;Exhibits;Exposure to;General Population;Gingiva;Growth;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Health;high risk population;Histopathology;HIV;HIV Infections;HIV Seronegativity;HIV therapy;HPV screening;Human papilloma virus infection;Human Papillomavirus;Human papillomavirus 16;Immunohistochemistry;Impairment;In Vitro;in vivo;Incidence;Individual;Infection;infection risk;Intervention;Lesion;Lymphocyte Count;Maintenance;Mediating;Modeling;Mouth Diseases;Mucous Membrane;Oncogenic;Oral;oral HPV;oral HPV infection;oral HPV-positive head and neck cancers;Oral mucous membrane structure;Oral Pathology;oral tissue;Pathology;patient oriented;patient population;Patient risk;Patients;Permeability;Persons;Population;Populations at Risk;pre-exposure prophylaxis;Predisposition;Prevalence;prevent;prospective;Protease Inhibitor;protein expression;Regimen;repaired;Reporting;Research Personnel;Residual state;Risk;Risk Factors;Role;Sampling;screening;Stratified Epithelium;Stratified Squamous Epithelium;success;Testing;Tight Junctions;Time;Tissue Model;Tissues;Toxic effect;Viral Load result;Virus;Virus Diseases;volunteer

PROJECT_TITLE: The role of antiretroviral therapy in susceptibility to oral human papillomavirus (HPV) infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 CC (10)]


ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE While there are many important health benefits of physical activity, how exercise exerts its effects is not fully understood. A more comprehensive understanding of the molecular mechanisms underlying the responses to exercise would significantly impact public health. Continuation of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) will achieve its objective of generating a comprehensive map of the molecular responses to acute exercise and exercise training. with a long-range goal of elucidating the mechanisms by which exercise improves health.

PI_NAMEs: MONTGOMERY, STEPHEN ;SNYDER, MICHAEL P. (contact)

PROJECT_TERMS: Acute;Adipose tissue;Advocate;Affect;Age;Algorithms;Alleles;Animals;Architecture;ATAC-seq;Atlases;Bioinformatics;Biological Assay;Biological Process;Biological Sciences;Blood;career development;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chemicals;Chromatin;Chronic;clinical center;Collaborations;Collection;Communities;community barrier;Data;data access;Data Analyses;data analysis pipeline;Data Collection;Data Set;data sharing;data submission;Databases;Development;Disease Outcome;Ensure;Environment;epigenome;epigenomics;Exercise;exercise intervention;exercise training;Fingerprint;Funding;gene regulatory network;Generations;Genes;Genetic;genetic profiling;Genetic Transcription;Genome;genome sequencing;Genomics;Genotype-Tissue Expression Project;Goals;Health;Health Benefit;Human;human tissue;improved;Individual;individual response;Infrastructure;insight;Link;lipidomics;Manuscripts;Maps;Measurement;Measures;medical schools;Membrane Proteins;Metabolic;metabolomics;Methods;Mission;Molecular;Molecular Profiling;Muscle;new technology;novel;Output;Participant;Pathway interactions;Peripheral Blood Mononuclear Cell;Phase;Physical activity;physical inactivity;Physiological;Population;Process;Production;programs;Protein Isoforms;Proteomics;Protocols documentation;Public Health;Publications;Quality Control;Quantitative Trait Loci;Rattus;recruit;Reproducibility;Research;response;RNA;RNA Splicing;Sampling;sedentary;Sequence Read Archive;sex;Signal Transduction;Site;subcutaneous;Suspensions;Technology;Therapeutic;Tissues;tool;Training;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Transducers;Variant;Whole Blood;whole genome

PROJECT_TITLE: Stanford MoTrPAC Site for Genomes, Epigenomes and Transcriptomes


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CIUDAD DE BUENOS AIRES

ORG_COUNTRY: ARGENTINA

ORG_FIPS: AR

ORG_NAME: INSTITUTO DE EFECTIVIDAD CLINICA Y SANIT

PHR: PROJECT NARRATIVE LMICs’ research institutions are limited in institutional competitiveness and productivity due to scarcity of resources to set well-functioning research administration operations. Strengthening administrative infrastructure to support grant application preparation, submission, and management in the South American region is a challenge to equitable research that needs to be addressed. Good research management provides assistance to researchers in finding funding, guides them through the complexity of funders requirements and procedures, generates tools, and ensures compliance with research good practices. The introduction of good business practices for managing awards; and assisting the administrative staff in developing and implementing standard operating procedures, will result in more efficient and transparent funded-projects management, as well as increased compliance with NIH grant policies.

PI_NAMEs: FOLLIETTI, GILDA TAMARA (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Address;Administrator;Adopted;Applications Grants;Area;authority;Award;Businesses;Certification;Communities;Community of Practice;Consultations;Decision Making;Dedications;Educational workshop;Elements;empowerment;Ensure;Equity;Ethics;Event;Freedom;Funding;Goals;Grant;high standard;Human Resources;improved;Infrastructure;Institution;Knowledge;Knowledge acquisition;Leadership;Learning;Louisiana;low and middle-income countries;Manuals;Mentors;National Institute of Allergy and Infectious Disease;operation;Ownership;Policies;Practice Management;Preparation;Procedures;Process;Productivity;programs;Records;Regulation;repository;Research;Research Personnel;Research Project Grants;Resources;South America;South American;Structure;supportive environment;Time;tool;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: Research grants administration capacity strengthening in South America

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 NKD-D (J2)]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Multiple myeloma (MM) is a plasma cell disorder that accounts for ~10% of all hematologic malignancies. Proteasome inhibitors (PIs) in combination with other agents represent a major strategy for MM treatment, however rapidly developing resistance to PIs renders MM a largely incurable disease. In a current proposal we will characterize novel mechanisms revealing metabolic vulnerabilities of MM cells and novel agents that can exploit such vulnerabilities for MM treatment.

PI_NAMEs: NIKIFOROV, MIKHAIL  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Acids;Adrenoleukodystrophy;Affect;Anabolism;Antineoplastic Agents;Aryl Hydrocarbon Receptor;Binding;Blood;Bortezomib;Cell membrane;Cell Survival;Cells;Ceramides;Cessation of life;Chromosomal translocation;clinically relevant;Coenzyme A;Data;Disease;Drug resistance;efficacy evaluation;Endoplasmic Reticulum;endoplasmic reticulum stress;enzyme biosynthesis;Enzymes;experimental study;fatty acid biosynthesis;Fatty Acids;Genes;Genetic Transcription;Glycerol;Golgi Apparatus;Hematologic Neoplasms;Homeostasis;Hydro-Lyases;Immunoglobulin G;Immunoglobulins;Inherited;Intervention;lipid metabolism;Lipids;Lorenzo's oil;Maintenance;Malignant Neoplasms;Mediating;Membrane;Membrane Lipids;Messenger RNA;Metabolic;mouse model;mRNA Expression;Multiple Myeloma;Mus;Neurons;novel;novel strategies;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;physical property;Plasma;Plasma Cells;Play;Predisposition;Production;Property;Proteasome Inhibitor;Protein Export Pathway;Protein Tyrosine Kinase;Proteins;Receptor Protein-Tyrosine Kinases;Refractory;Regulation;Reporting;Resistance;Resistance development;response;Risk;Role;screening;Signal Transduction;Sphingolipids;synergism;Testing;Therapeutic Effect;therapy resistant;Time;transcription factor;Transcriptional Activation;Transcriptional Regulation;Transgenic Organisms;Very Long Chain Fatty Acid;Xenograft procedure

PROJECT_TITLE: Regulation and Function of Very Long Chain Fatty Acid Biosynthesis in Multiple Myeloma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-D(02)M]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: GREENSBORO

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTH CAROLINA AGRI & TECH ST UNIV

PHR: Narrative The ESTEEMED program at North Carolina Agricultural and Technical State University (NC A&T) will significantly increase the production of high achieving graduates who pursue advanced degrees in the biomedical sciences and diversify the STEM workforce. The program will use a persistence framework that combines an academic support system, early research experiences and mentoring, collaborative learning, and intrusive advising to cultivate the science identity of underrepresented minority students. The implementation of the goals, objectives and aims of the NC A&T ESTEEMED program will produce a stream of minority Ph.D. bioengineers and biomedical scientists who will address biomedical issues through the development of new and innovative technologies and cutting-edge research.

PI_NAMEs: KANIPES, MARGARET IMOGENE (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Academic support;Agriculture;Biology;Biomedical Engineering;Biomedical Research;biomedical scientist;bridge program;career;CCL7 gene;Chemistry;Communication;Development;Development Plans;Doctor of Philosophy;Educational workshop;Electronics;Engineering;Enrollment;expectation;experience;Faculty;faculty mentor;Future;gateway course;Goals;graduate student;innovative technologies;knowledge base;Learning;Mathematics;matriculation;Mentors;Minority;new technology;North Carolina;Oral;oral communication;Outcome;Participant;Pathway interactions;peer coaching;Preparation;Production;programs;Recruitment Activity;Research;research and development;Scholars Program;Science;Science, Technology, Engineering and Mathematics Education;Scientist;skill acquisition;skills;STEM career;STEM field;Stream;student mentoring;Students;success;summer research;Support System;symposium;Training Activity;tutoring;Underrepresented Minority;underrepresented minority student;Universities;Work;Writing

PROJECT_TITLE: NC A&T ESTEEMED Program


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PI_NAMEs: ALAM, M. ASHFAQUL  (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Antibiotic Resistance;Biology;Campylobacter jejuni;Centers of Research Excellence;Chemicals;druggable target;enteric infection;enteric pathogen;Escherichia coli;gut inflammation;gut microbiota;human pathogen;innovation;Intervention;microbial;Pharmacologic Substance;Research;small molecule;therapy development

PROJECT_TITLE: Elucidating the chemical biology of the druggable targets in enteric pathogens C. jejuni & E. coli


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Clinical Research;Mental Health

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE This training grant aims to grow the field of geriatric mental health investigators capable of conducting independent, multidisciplinary, team-based research in translational, interventions, and services research to the benefit of older Americans at risk for or already living with mood and anxiety disorders.

PI_NAMEs: AIZENSTEIN, HOWARD J (contact);ANDREESCU, CARMEN

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Clinical Research;geriatric mental health;Research Training;Translational Research

PROJECT_TITLE: Clinical and Translational Research Training in Geriatric Mental Health


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: OVERALL PROJECT NARRATIVE Cancer is responsible for about one in every four deaths in the United States, and new treatments are urgently needed. It is the overall goal of the integrated studies in this renewal application to discover novel chemicals from selected tropical rainforest plants, as well as lichens, cyanobacteria and fungi, for development as cancer chemotherapeutic agents, particularly for tumors not cured by current treatment methods.

PI_NAMEs: FUCHS, JAMES R;KINGHORN, ALAN DOUGLAS (contact);OBERLIES, NICHOLAS H.

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: analog;anti-tumor drug;Anti-tumor Natural Products;anticancer activity;Antineoplastic Agents;Binding Proteins;Biological;Biological Assay;Biological Testing;Biometry;Cancer cell line;cancer therapy;Cells;Cessation of life;Chemicals;Chemistry;chemotherapeutic agent;Chicago;Collection;Communication;Comprehensive Cancer Center;computerized;Consultations;Country;Coupled;Cyanobacterium;data management;Databases;Decision Making;Developing Countries;Development;Disease;Doctor of Philosophy;drug development;drug discovery;Drug Industry;Drug Kinetics;Evaluation;experience;Fiber;Formulation;Fractionation;Funding;fungus;Genomics;Goals;Human Resources;Illinois;In Vitro;in vitro testing;in vivo;in vivo Bioassay;Institution;Lead;Libraries;Lichen - organism;literature survey;Malignant Neoplasms;Marketing;meetings;men;Metabolism;Methods;Modification;Molds;National Cancer Institute;National Center for Advancing Translational Sciences;Natural Compound;Natural Products;Neurofibromatosis 2;North Carolina;novel;novel anticancer drug;Ohio;Organism;Participant;Pediatric Hospitals;Pharmaceutical Chemistry;Plants;Play;Principal Investigator;Process;programs;Provider;Regimen;Research;Research Personnel;Resistance;Resources;Role;Sampling;scale up;Solubility;Structure;Taxonomy;Testing;Therapeutic;Toxicology;tumor;tumor growth;United States;United States National Institutes of Health;Universities;Woman;Work;Xenograft procedure

PROJECT_TITLE: Discovery of Anticancer Agents of Diverse Natural Origin


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Complementary and Integrative Health;Dietary Supplements;Natural Products;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: The primary purpose of Project 1 of the Program Project is to discover new cancer chemotherapeutic agents from plants, that will be collected from tropical rainforests, as well as U.S. coastal lichens and their fungal associates. In order to do this, our group will perform chemical and biological studies in a coordinated manner with the other components of this project.

PI_NAMEs: KINGHORN, ALAN DOUGLAS (contact)

PROJECT_TERMS: Acoustic Neuroma;anti-cancer;Antineoplastic Agents;ANXA5 gene;Apoptosis;Biological;Biological Assay;Biological Testing;Biometry;Breast;cancer cell;Cancer cell line;Cells;Chemicals;Chemistry;chemotherapeutic agent;Chicago;Chromatography;Collaborations;Collection;college;Colon;Comprehensive Cancer Center;cytotoxicity;Development;DNA Damage;DNA topoisomerase II alpha;DNA Topoisomerases;drug development;Drug Kinetics;Evaluation;experience;Fermentation;Fiber;Formulation;Fractionation;Funding;fungus;Glutathione;Goals;HT29 Cells;Human;Illinois;In Vitro;in vitro Bioassay;in vivo;Knowledge;Lead;Lichen - organism;Location;Malignant Neoplasms;MDA MB 231;MDA MB 435;Melanoma;Membrane Potentials;meningioma;Metabolism;Methodology;Methods;microbial;Mitochondria;Modernization;Monitor;multidisciplinary;Mus;National Cancer Institute;National Center for Advancing Translational Sciences;Neurofibromatosis 2;North Carolina;novel anticancer drug;Nuclear;Nuclear Receptors;Ohio;Organism;Outcome;Ovarian;Pediatric Hospitals;Pharmaceutical Chemistry;Pharmacy facility;Phytochemical;Plant Extracts;Plants;Procedures;Process;Program Research Project Grants;programs;Reactive Oxygen Species;Research Personnel;Ribosomal DNA;Sampling;scale up;screening;Solubility;solvent extraction;Solvents;Standardization;Structure;Taxonomy;Techniques;Testing;United States National Institutes of Health;Universities;Work;X-Ray Crystallography;Xenograft procedure

PROJECT_TITLE: Project 1: Tropical Plants Biological Testing


NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Dietary Supplements;Natural Products

PHR: The primary purpose of Project 2 of this Program Project is to discover new cancer chemotherapeutic leads from cyanobacteria and to supply plants from tropical rainforests for further investigation in Project 1. The proposed research will impact human health by creating new lead compounds for the development of drugs to treat cancer. Some of the compounds discovered may work by new mechanisms of action, thus increasing our understanding of how to treat this disease.

PI_NAMEs: ORJALA, JIMMY  (contact)

PROJECT_TERMS: Anabolism;anti-cancer;Anti-tumor Natural Products;Antineoplastic Agents;Biological;Biological Assay;Biological Testing;Botanicals;Chemicals;Chemistry;Chicago;Collection;college;Country;Cyanobacterium;Disease;drug development;Drug Kinetics;Dryness;Elements;Evaluation;experience;Formulation;Fractionation;Fresh Water;Gene Cluster;Genome;Genomics;Goals;Great Lakes Region;Health;Heat-Shock Response;Human;Illinois;improved;In Vitro;in vivo;Individual;Investigation;Laos;Lead;Libraries;Light;Malignant Neoplasms;Metabolism;Midwestern United States;Mining;Monitor;Natural Products;Natural Source;North Carolina;novel;novel anticancer drug;Ohio;Pathway interactions;Pharmacy facility;Phytochemical;Plants;Production;programs;Protocols documentation;Provider;Puerto Rico;Research;Research Activity;Sampling;Solubility;Source;stressor;Structure;System;Taxonomy;Testing;Therapeutic;Universities;Weight;Work

PROJECT_TITLE: Project 2: Aquatic Cyanobacteria Plant Collections


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative (3-sentence limit) This proposal aims to develop new technologies for rapid (1 min/dose; over 10 doses per hour) production of exogenous contrast agents for molecular imaging of cellular metabolism in vivo. Our overall goal is to develop clinical-scale production technology for preparation of non-radioactive hyperpolarized [1-13C]pyruvate (already in evaluation in nearly 30 clinical trials) that probes aberrant energy metabolism in a manner similar to FDG PET but with the added benefits of 1-minute scan time and no ionizing radiation. We will also validate the new contrast agent production technology in feasibility studies with cellular models.

PI_NAMEs: CHEKMENEV, EDUARD  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: 3-Dimensional;Address;alcohol content;aqueous;Award;Biochemical Pathway;biomaterial compatibility;Buffers;catalyst;Cell Line;Cell model;Cells;cellular imaging;Clinical;clinical application;clinical translation;Clinical Trials;cohort;Collaborations;commercialization;Complex;Contrast Media;cost;cost effective;cryogenics;Detection;Devices;Diagnosis;Diagnostic;diagnostic tool;Disease;Dose;Emission-Computed Tomography;Energy Metabolism;Ethanol;Evaluation;Excision;Fasting;Feasibility Studies;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Formulation;Future;Gases;Goals;Hela Cells;high risk;Hour;Image;imaging modality;Imaging Techniques;Imaging technology;improved;in vivo;Injectable;instrumentation;invention;Ionizing radiation;irradiation;Isotonic Solutions;Legal patent;magnetic field;Magnetic Resonance Imaging;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mammography;Maps;MCF10A cells;MCF7 cell;Metabolic;metabolic imaging;Metabolism;metal complex;Metals;Methods;microwave electromagnetic radiation;Minor;Modality;Molecular;molecular imaging;Monitor;MRI Scans;new technology;next generation;non-invasive imaging;Normal Cell;Nuclear;operation;Output;Patients;Positron-Emission Tomography;pre-clinical;Preparation;Process;Production;Protons;prototype;Pyruvate;radio frequency;Reaction;reconstitution;Reporting;Research Personnel;response;Roentgen Rays;Route;scale up;Scanning;screening;Signal Transduction;soft tissue;Source;Stress;success;Technology;technology development;Temperature;Time;Tissues;treatment response;tumorigenic;Use of New Techniques;Validation;Water;Work;X-Ray Computed Tomography

PROJECT_TITLE: Rapid low-cost production of contrast agents for metabolic imaging

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Cancer

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE Tyrosine phosphatases are emerging as an important class of enzymes in cancer signaling, and many members of this enzyme family could be fruitful drug targets for precision medicines and immunotherapies. While genetic evidence supports a role for many tyrosine phosphatases in cancer etiology and therapeutic response, it has been technically challenging to obtain detailed knowledge of the specific cellular functions of these proteins. In this project, we will develop a robust protein engineering strategy to identify direct substrates of individual tyrosine phosphatases in live cells, thereby allowing us to pinpoint specific biochemical functions across this important enzyme family.

PI_NAMEs: SHAH, NEEL H (contact)

PROGRAM_OFFICER_NAME: KYI, CINDY WIN

PROJECT_TERMS: Active Sites;Amber;Amino Acids;Animals;Binding;Binding Proteins;Binding Sites;Biochemical;Bioinformatics;Biological Assay;Biological Models;cancer cell;Cancer Etiology;cancer therapy;Catalysis;Cell Line;Cell Physiology;Cells;Clinical;Clinical Trials;Complex;Crosslinker;design;Development;Dominant-Negative Mutation;drug discovery;Drug Targeting;Electrophoretic Mobility Shift Assay;Engineering;enzyme activity;enzyme substrate;enzyme substrate complex;Enzymes;Event;experimental study;Exposure to;Family;Genetic;Genetic Code;Human;Immune response;Immunity;Immunomodulators;Immunoprecipitation;In Vitro;Individual;interest;Knowledge;Light;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;Measures;Mediating;member;Methods;Modeling;Modification;mutant;Mutation;Oncogenic;overexpression;Peptides;personalized immunotherapy;Phosphopeptides;Phosphoric Monoester Hydrolases;Phosphorylation;Positioning Attribute;Post-Translational Protein Processing;precision medicine;Protein Conformation;Protein Dephosphorylation;Protein Engineering;Protein Family;protein function;Protein Tyrosine Kinase;Protein Tyrosine Phosphatase;Proteins;Proteome;Proteomics;Protocols documentation;PTPN1 gene;PTPN11 gene;PTPRC gene;receptor;Reporting;Role;Signal Pathway;Signal Transduction;Site;Specificity;Structure;Substrate Specificity;targeted cancer therapy;Techniques;Testing;tool;treatment response;Tumor Suppressor Proteins;Tyrosine Phosphorylation;Tyrosine Phosphorylation Site;Ultraviolet Rays;virtual;Work

PROJECT_TITLE: A Generalizable Photo-Crosslinking Strategy to Identify Tyrosine Phosphatase Substrates


NIH_SPENDING_CATS: Biotechnology;Cancer;Natural Products

PHR: Our team will study fungal cultures as a source of new anticancer drug leads. We have a strong track record of success, having identified and studied hundreds of fungal metabolites with anticancer activities. Our current proposal strives to use innovative technique to identify new fungal metabolites, including methods to probe fungal chemistry in situ, as well as, generate non-natural natural products.

PI_NAMEs: OBERLIES, NICHOLAS H. (contact)

PROJECT_TERMS: Address;Anabolism;analog;anti-cancer;anticancer activity;Antineoplastic Agents;Biological;Biological Assay;Biological Testing;Biology;cancer cell;cancer therapy;Cell Death;Cells;Chemicals;Chemistry;Clinic;Coculture Techniques;Collaborations;Databases;Development;Dose;drug discovery;Drug Kinetics;Drug resistance;erastin;Evaluation;Fermentation;Fluorine;Formulation;Funding;fungus;Generations;Goals;Imidazole;In Situ;in vivo;innovation;interest;Ketones;Laboratories;Lead;Libraries;Literature;Maps;Mesothelioma;Metabolism;Methods;Mission;Modeling;Molds;nanoparticle;Natural Products;Natural Products Chemistry;Nature;North Carolina;novel;novel anticancer drug;Penicillins;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology Study;preclinical development;Preclinical Drug Development;Process;Production;programs;Protocols documentation;refractory cancer;Research;Research Personnel;Resources;Sampling;scaffold;scale up;Scientist;skills;Source;Stress;Structure;Structure-Activity Relationship;success;synergism;Techniques;Testing;The science of Mycology;Time;tool;Translating;Translations;Universities;Visualization;Work

PROJECT_TITLE: Project 3: Filamentous Fungi, Biological Testing


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: Project Narrative There is an urgent need for powerful and effective statistical tools to determine the most important risk factors of mental illness, especially as the list of potential risk factors grows. The proposed research will develop guidelines and freely-available online applications to allow researchers to use novel Bayesian variable selection methods to overcome current challenges to reliably predict mental illness. These methods are then applied to understand important predictors of Obsessive Compulsive Disorder symptoms in a large sample of adults across the lifespan. The findings of this research can inform efforts to identify and intervene to help at risk individuals to ultimately reduce the burden of mental illness.

PI_NAMEs: BAINTER, SIERRA  (contact)

PROJECT_TERMS: abuse neglect;Acceleration;Accounting;Address;Adult;Age;Anxiety;Area;Award;Behavioral;Biological Factors;biomarker identification;Brain;burden of illness;Chronic;Clinical;comorbidity;Computer Simulation;Computer software;Data;Data Set;Databases;Development;Disease;Early identification;Early Intervention;Environmental Risk Factor;Etiology;Evaluation;experimental study;Funding;Goals;Guidelines;Individual;Investigation;Journals;life span;Measures;Mental disorders;Mental Health;Mentors;Methodology;Methods;Modeling;National Institute of Mental Health;negative affect;neural;neuroimaging;Neurosciences;novel;Obsessive compulsive behavior;Obsessive-Compulsive Disorder;Onset of illness;open source;Outcome;Personality;Persons;Phenotype;Positioning Attribute;Predictive Value;Prevention;Probability;psychologic;Psychological Factors;Psychology;Psychopathology;public database;Recommendation;Research;Research Design;Research Personnel;resilience factor;Resources;Risk;Risk Factors;Sampling;simulation;Statistical Methods;Stressful Event;stressor;substance use;Symptoms;Techniques;Temperament;theories;Time;tool;Training;Uncertainty;Universities;user-friendly;Visualization;Work

PROJECT_TITLE: Bayesian Variable Selection Methods to Accelerate Identification of Important Psychological Predictors and Neural Substrates of Psychopathology

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


PROJECT_TERMS: Address;Advisory Committees;Antineoplastic Agents;Authorship;Biological;Biological Assay;Biometry;Biostatistics Core;Budgets;Chemicals;chemotherapeutic agent;Chicago;Collaborations;computerized data processing;Cyanobacterium;Data;Data Display;Databases;Dependence;design;Development;Disputes;Drug Kinetics;Effectiveness;Electronics;Ensure;Evaluation;experimental analysis;Experimental Designs;Fostering;fungus;Goals;Grant;Housing;Illinois;Industrialization;Information Dissemination;Institution;Investigation;Laboratories;Leadership;Lichen - organism;Malignant Neoplasms;meetings;member;Methods;Modeling;Molds;multidimensional data;North Carolina;novel;Occupational activity of managing finances;Ohio;operation;Persons;Pharmaceutical Chemistry;Pharmacologic Substance;Plants;preservation;Program Effectiveness;Program Efficiency;Program Research Project Grants;programs;Provider;Research;Research Personnel;Research Project Grants;Resource Allocation;Scientist;Services;Statistical Methods;Structure;symposium;Teleconferences;Telephone;Training;tumor;Universities;Validation;videoconference;Visual;Work

PROJECT_TITLE: Core A: Administrative and Biostatistics Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Depression;HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: LAY NARRATIVE Mood disorders, including depression, and loss of motivation are extremely common and debilitating in people with HIV, despite effective antiretroviral therapy. These disorders are likely to be related to changes in systemic and/or brain iron metabolism. This study will use new and state-of-the-art brain imaging techniques to measure brain iron in people with and without HIV infection and determine its contributions to depressive and other mood- related symptoms.

PI_NAMEs: KALLIANPUR, ASHA R (contact);LI, XU

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Accounting;Address;Adherence;Affective;Age;Anabolism;Anti-Retroviral Agents;antiretroviral therapy;Anxiety;Area;Attention;Basal Ganglia;behavior measurement;Behavioral;Biological Availability;Biological Markers;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;Brain imaging;brain iron;Brain Mapping;Brain region;Cerebrospinal Fluid;Cerebrovascular Circulation;Chronic;clinical care;Clinical Management;Cognition Disorders;cognitive control;cognitive function;cognitive process;cognitive system;Corpus striatum structure;Data;Deposition;Depressive disorder;depressive symptoms;Disease;Dopamine;Energy Metabolism;Equilibrium;Etiology;experience;Foundations;functional status;Funding;Future;Genetic study;Hippocampus;HIV;HIV Infections;HIV Seronegativity;Homeostasis;Imaging Techniques;Impaired cognition;Individual;Inflammation;Investigation;Iron;iron metabolism;Link;Longevity;Magnetic Resonance Imaging;Maintenance;Maps;Measures;Mental Depression;Mental disorders;Mitochondria;Modeling;Molecular Epidemiology;monoamine;Mood Disorders;Moods;mortality;Motivation;Myelin;Nerve Degeneration;neuroAIDS;neuroimaging;neuroinflammation;Neurologic;neuropsychiatric disorder;neuropsychiatric symptom;neuropsychiatry;Neurotransmitters;new therapeutic target;NIH Office of AIDS Research;novel;Oligodendroglia;Parents;Participant;Pathogenicity;Pathway interactions;Persons;Pharmaceutical Preparations;Predisposition;Prefrontal Cortex;Prevalence;Process;Proteins;Public Health;Quality of life;Regulation;Research;Research Domain Criteria;Research Personnel;Resistance;reward processing;Rewards;Risk;Semaphorins;Serotonin;Serum;sex;Short-Term Memory;Symptoms;Techniques;Testing;Thalamic structure;therapeutic target;treatment adherence;United States National Institutes of Health;Viral;Virus

PROJECT_TITLE: Quantitative Susceptibility Mapping of Brain Iron in People with HIV: Mechanistic Links to Neuropsychiatric Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-T(90)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Complementary and Integrative Health;Genetics;Human Genome;Natural Products;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: The overarching goal of this Program Project is to isolate novel agents from natural sources for the treatment of cancer. The role of Core 1 is to provide biological testing using a variety of molecular, cellular and animal-based systems to identify promising leads for further development. Core 1 will obtain materials for testing from each of Projects 1-3, work with Core A on biostatistical analysis, and identify leads that Core 2 can modify synthetically to enhance activity and investigate for pharmacokinetic and other parameters as candidate drug leads.

PI_NAMEs: BURDETTE, JOANNA E (contact)

PROJECT_TERMS: 3-Dimensional;analog;Animal Experiments;Animal Model;Animals;anti-cancer;anti-cancer research;Anti-tumor Natural Products;Antineoplastic Agents;Autophagocytosis;Biological;Biological Assay;Biological Testing;Biometry;Cancer cell line;Cancer Model;cancer therapy;Cell Line;Cells;Cellular Assay;chemical synthesis;chemotherapy;Collaborations;Complex Mixtures;Crude Extracts;Cyanobacterium;cytotoxic;cytotoxicity;cytotoxicity test;Data;Development;Dose;drug candidate;Drug Kinetics;efficacy evaluation;efficacy study;Evaluation;experimental study;Fingerprint;Formulation;Foundations;fungus;Genetic Transcription;Goals;Growth;high throughput screening;Human;Immune system;improved;In Vitro;in vivo;in vivo evaluation;Individual;Industrialization;Lead;Lichen - organism;Malignant neoplasm of ovary;Mass Spectrum Analysis;Materials Testing;Modeling;Molecular;Molecular Profiling;Mus;National Center for Advancing Translational Sciences;Natural Products;Natural Source;novel;Nude Mice;Nutrient;Pathway interactions;Penetration;Pharmaceutical Preparations;Phenotype;Plants;programs;Proteins;Proteomics;Reporting;Research Personnel;response;Role;Route;screening;Solid;Solvents;spheroids;Structure;Structure-Activity Relationship;System;Testing;Toxic effect;transcriptome sequencing;transcriptomics;tumor;United States National Institutes of Health;Work;Xenograft procedure

PROJECT_TITLE: Core:1 Biological Testing


NIH_SPENDING_CATS: Cancer;Immunotherapy;Skin Cancer

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE While targeted small molecule inhibitors and immune checkpoint antibodies have increased long-term survival in advanced-stage cutaneous melanoma, the majority of patients still do not benefit and many of the treatment regimens are associated with significant toxicities. This application aims to provide pre- clinical data for targeted cyclin-dependent kinase inhibitor-based combinations that will provide maximal anti-tumor efficacy while minimizing patient toxicities.

PI_NAMEs: APLIN, ANDREW ERIC (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Agonist;anti-PD1 therapy;Antibodies;Antigen-Presenting Cells;BRAF gene;CD8-Positive T-Lymphocytes;CDK4 gene;Cell Cycle Progression;Cell Cycle Regulation;Clinical;Clinical Trials;clinically relevant;Clonal Evolution;Combined Modality Therapy;Cutaneous Melanoma;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinases;Cyclins;Data;Drug resistance;Drug Tolerance;ERBB2 gene;Estrogen receptor positive;Evolution;FDA approved;Funding;Genetic;Genotype;Goals;Heterogeneity;immune checkpoint;Immune system;Immunocompetent;Immunologic Sensitization;Immunooncology;improved;in vivo;in vivo Model;Incidence;Infiltration;inhibitor;inhibitor therapy;insight;Leucocytic infiltrate;Malignant Breast Neoplasm;Malignant Neoplasms;MAPK3 gene;Measures;Mediating;MEKs;Melanoma;Melanoma Cell;Melanoma patient;Mesenchymal;Modeling;Mus;mutant;Mutation;NF1 gene;NF1 mutation;novel;novel therapeutic intervention;OX40;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phosphorylation;PIK3CA gene;pre-clinical;Pre-Clinical Model;prevent;protein kinase inhibitor;Publishing;Quality of life;Regimen;Reporter;Residual Neoplasm;Resistance;resistance mechanism;response;Ribosomal Protein S6;Role;Sampling;Schedule;Signal Transduction;single cell analysis;small molecule inhibitor;T-Lymphocyte;targeted treatment;Testing;Therapeutic;TNFSF4 gene;Toxic effect;Treatment Protocols;treatment response;tumor;tumor heterogeneity;tumor-immune system interactions;Up-Regulation;Vimentin;Work

PROJECT_TITLE: Targeted therapies in cutaneous melanoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: PROJECT NARRATIVE Catalytic Processes for Stereoselective Radical Cyclization Reactions  In modern pharmaceutical industry, where the market share of single enantiomer chiral drugs continues to rise, there are growing demands for developing practical and economical methods for the enantioselective synthesis of biologically and pharmaceutically important carbocyclic and heterocyclic compounds in an enantioenriched or enantiopure form. Compared to a racemic mixture, the use of an enantiomerically pure compound improves the desired bioactivity and while reducing toxicity because enantiomeric isomers often exhibit different biological activities. For drug discovery and development, it is desirable to prepare both enantiomers of a new chiral drug candidate for testing their separate activities.

PI_NAMEs: ZHANG, X. PETER  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Natural Products

PHR: The primary goal of Core 2 is to support the discovery, characterization and optimization of novel anticancer agents through the synthesis, structural modification, and evaluation of pharmacokinetic properties of lead compounds discovered in Projects 1-3 that demonstrate promising biological activity. Core 2 will work closely with Cores A and 1 to develop these compounds as potential therapeutic agents.

PI_NAMEs: FUCHS, JAMES R (contact)

PROJECT_TERMS: Acceleration;analog;analytical method;Antineoplastic Agents;Binding;Biological;Biological Assay;Biological Models;Biometry;Blood Cells;Cells;chemical synthesis;Chemicals;Chicago;Collaborations;Comprehensive Cancer Center;Consultations;Cyanobacterium;Data;Derivation procedure;Development;Discipline;Dose;drug development;drug discovery;Drug Kinetics;Ensure;Enzymes;Evaluation;experience;Fiber;Formulation;Funding;Generations;Goals;Illinois;In Vitro;in vivo;insight;Lead;Lichen - organism;metabolic profile;Methods;Modification;Molds;Mus;Natural product discovery;Natural Products;Natural Selections;Nature;North Carolina;novel;novel anticancer drug;Ohio;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Plant natural product;Plasma;Preparation;Process;programs;Property;Proteins;Recording of previous events;Research Personnel;Resource Sharing;Role;scaffold;scale up;Solubility;Structure-Activity Relationship;success;System;Testing;Therapeutic Agents;Time;Universities;Work

PROJECT_TITLE: Core 2: Medicinal Chemistry and Pharmacokinetics Core


ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project narrative Almost a million patients undergo open heart surgery annually in the US, and implantation of temporary epicardial pacing leads is the standard of care for patients undergoing cardiac surgery to provide on-demand pacing the heart should arrhythmias such as bradycardias occur. The current temporary epicardial pacing suffers from two severe limitations: 1) The traumatic implantation and removal of the pacing lead, and 2) inflammatory response induced lead-tissue fibrosis and resultant early device failure. Here we propose to develop a new epicardial pacing device in a form of an electrically conductive bioadhesive (e-bioadhesive) patch that prevents cardiac trauma and fibrous capsule, which could greatly improve safety in the perioperative period for vulnerable patients.

PI_NAMEs: GRIFFITHS, LEIGH GARETH;NABZDYK, CHRISTOPH GUNTHER STANISLAW;ZHAO, XUANHE  (contact)

PROJECT_TERMS: Acceleration;Address;Adhesions;Adhesives;Arrhythmia;Benchmarking;bioelectronics;Biomedical Engineering;Bradyarrhythmias;Bradycardia;capsule;Cardiac;Cardiac conduction system;cardiac pacing;Cardiac Surgery procedures;Cessation of life;Chest wall structure;Clinical;clinical translation;clinically relevant;Communication;Data;Degree Completion;design;Devices;Electric Conductivity;Electrodes;Electrophysiology (science);Ensure;Epicardium;Equipment Malfunction;Evaluation;Excision;fabrication;Failure;Family suidae;FDA approved;Fibrosis;Foreign Bodies;Heart;Heart Atrium;Heart Block;heart rhythm;Hemorrhage;Hospitalization;Implant;implantation;improved;In Vitro;in vivo;Inflammation;Inflammatory Response;Joints;Lead;Left;Life;Microfluidics;Nature;Operative Surgical Procedures;Organ;Patient Care;patient safety;Patients;Perforation;Performance;Perioperative;Physiologic pulse;porcine model;Postoperative Period;pre-clinical;preservation;prevent;Process;Publications;response;Risk;Rodent;Rodent Model;Safety;Series;standard of care;System;Technology;Tissue Adhesives;Tissues;Translating;translational medicine;Translational Research;Trauma

PROJECT_TITLE: Atraumatic Non-fibrotic Epicardial Pacing with E-Bioadhesive Devices

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative G protein coupled receptors (GPCRs) are a major class of transmembrane receptors responsible for recognition of a large class of diverse ligands and are major targets of therapeutic drugs. Here we propose a comprehensive analysis of mechanisms for GPCR-dependent regulation of downstream signaling processes. We expect to reveal novel signaling mechanisms with broad implications for GPCR signaling in general, and new paradigms for adrenergic regulation of cardiac function and failure, that have the potential to drive development of novel therapeutics.

PI_NAMEs: SMRCKA, ALAN V. (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Adenylate Cyclase;Adrenergic Agents;Adrenergic Receptor;Area;beta-adrenergic receptor;Cardiac Myocytes;career;Cells;chromatin remodeling;Development;experimental study;follow-up;Functional disorder;Funding;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Expression;Genes;Golgi Apparatus;GTP-Binding Protein alpha Subunits;GTP-Binding Proteins;Heart failure;heart function;Heart Hypertrophy;Hydrolysis;in vivo;Individual;interest;Label;Laboratories;Ligands;Mass Spectrum Analysis;Mediating;Membrane;Methods;Molecular;novel;novel therapeutics;Pathway interactions;Pharmaceutical Preparations;Phosphatidylinositols;Phospholipase C;Physiology;Play;Process;protein protein interaction;Proteomics;receptor;Receptor Signaling;Recycling;Regulation;response;Rest;Role;Second Messenger Systems;Signal Pathway;Signal Transduction;Signal Transduction Pathway;success;targeted treatment;Testing;Tissues

PROJECT_TITLE: Understanding and Manipulating G Protein α Subunit and Phospholipase C Signaling Networks

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Natural Products

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE  Natural products chemistry and organic synthesis are two enabling disciplines that fuel the engine of small- molecule drug discovery. These fields impact existing pharmaceutical agents, compounds currently in the clinical pipeline heading toward approved therapeutics, and basic research to develop the improved drugs of tomorrow. In our research program (i) we provide new knowledge about the structures of natural products as well as an understanding of how they are created by their producing organisms and (ii) we develop new paradigms that researchers can use for the synthesis of novel compounds having potential as new, clinically relevant drug candidates. (3 sentences)

PI_NAMEs: HOYE, THOMAS R. (contact)

PROJECT_TERMS: Abate;Address;Anabolism;Basic Science;Biological;Catalysis;chemical reaction;Chemicals;Chemistry;Clinical;clinically relevant;Communication;Communities;coping;Cyclic Peptides;Development;Diels Alder reaction;Discipline;drug candidate;drug discovery;effectiveness evaluation;Funding;Future;Genome Mappings;HRK gene;improved;innovation;insight;interest;Knowledge;Methodology;Methods;Natural Products;Natural Products Chemistry;novel;novel strategies;Organic Chemistry;Organic Synthesis;Organism;ottelione A;Outcome;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;programs;Property;Reaction;Research;Research Personnel;Research Support;secondary metabolite;Skeleton;small molecule;Structure;Teaching Method;Therapeutic Research;Work

PROJECT_TITLE: Synthesis, Structure, and Mechanism of Biorelevant Molecules and Reactions

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Endocrine Disruptors;Heart Disease;Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE This proposed study seeks to examine the combined effect of lead (Pb), cadmium (Cd), mercury (Hg), perfluorooctane sulfonic acid (PFOS), and perfluorinated alkylated substances (PFOA) on stress, cardiovascular disease (CVD) risk and CVD mortality. The primary analysis will include: (1) assessing the effects of Pb, Cd, Hg, PFOA, and PFOS exposures on individual and neighborhood stress and (2) determining the effects of Pb, Cd, Hg, PFOA, and PFOS exposures on CVD risk and mortality. This study will help close the gap in knowledge of the effects of multiple environmental pollutants on stress and cardiovascular health and will further our understanding of the role that the social environment and the physical environment pose for potentially serious health risks to individuals.

PI_NAMEs: OBENG-GYASI, EMMANUEL  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: absorption;Address;Affect;Agriculture;alcohol misuse;Algorithms;allostatic load;analytical method;Behavioral;Biological;Black race;Blood;Cadmium;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Censuses;Cessation of life;Chronic;Complex;Crime;Data;Data Analyses;Data Analytics;design;Development;Disease;drug misuse;Elderly;Elements;Environmental Epidemiology;Environmental Exposure;Environmental Pollutants;Environmental Risk Factor;environmental stressor;Exclusion;experience;Exposure to;Functional disorder;Geography;Goals;Health;High Pressure Liquid Chromatography;Hispanic;Historically Black Colleges and Universities;Human;indexing;Individual;Inductively Coupled Plasma Mass Spectrometry;Inflammatory;Infrastructure;Institution;Intervention;ionization;Knowledge;Lead;Lead levels;Life;Life Cycle Stages;Link;Literature;low socioeconomic status;Measures;Mercury;Metabolic;Metal exposure;Metals;Modeling;mortality;National Health and Nutrition Examination Survey;Neighborhoods;North Carolina;Outcome;Outcome Study;perfluorooctane sulfonate;Personal Satisfaction;Phase;Physical environment;Physiological;pollutant;Poly-fluoroalkyl substances;Population;programs;Prospective Studies;psychosocial;Psychosocial Stress;psychosocial stressors;recruit;Research;Research Project Grants;Retrospective Studies;Risk;Role;Sampling;Secondary to;Serum;social;Social Environment;Solid;Stress;stressor;student training;Students;Sum;Surveys;System;tandem mass spectrometry;Techniques;theories;Time;Training;United States;Universities;Violence;Vulnerable Populations;Work

PROJECT_TITLE: The Impact of Combined Exposure to Metals and Per- and Polyfluoroalkyl Substances on Stress, Cardiovascular Disease Risk and Mortality


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: This project builds on a growing body of evidence that supports an association between periodontitis and Alzheimer’s disease (AD) and related dementias (ADRD). By assessing clinical and microbial features of periodontitis in a longitudinal manner, along with key elements of the inflammatory response, within an established, rigorously developed diverse community-based aging study in Northern Manhattan, we have the unique opportunity to investigate a potentially causal association between periodontitis and incident ADRD, assessed through a comprehensive battery of neuropsychological tests, as well as through established neuroimaging and fluid biomarkers of AD. Given that a substantial proportion of AD cases occurs in the absence of established risk factors other than aging, and that periodontitis is largely preventable and treatable, identification of a novel, modifiable risk factor for AD would be extremely valuable from a public health standpoint and would influence the design of early intervention strategies.

PI_NAMEs: NOBLE, JAMES MCCALLUM (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acceleration;Adult;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's Disease Pathway;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Amyloidosis;Ancillary Study;Antibodies;atherogenesis;Atherosclerosis;Bacteremia;Bacteria;Biological;Biological Markers;Bone Marrow;Cerebrum;Clinical;clinical examination;cohort;Communities;comorbidity;Complex;Cytometry;Data;Dementia;dementia risk;dental biofilm;Dental Plaque;Deposition;design;Diabetes Mellitus;Disease;Disparity population;dysbiosis;Early Intervention;Education;Elderly;Elements;Enrollment;Epidemiology;epidemiology study;follow-up;Genes;Genetic;Health behavior;Height;Image;Immune;Immunoglobulin G;immunosenescence;Impaired cognition;improved;Individual;Infection;Inflammatory;inflammatory marker;Inflammatory Response;innovation;Intervention;Knowledge;Language;Life Style;Link;Liquid substance;literacy;Liver;Longitudinal cohort;Longitudinal Studies;longitudinal, prospective study;Magnetic Resonance Imaging;Measures;Medical;Memory;Memory impairment;metagenomic sequencing;microbial;Microbial Biofilms;microbiome;microbiota;Microvascular Dysfunction;Minority Groups;modifiable risk;monocyte;mortality;multi-ethnic;multimodality;Nerve Degeneration;neuroimaging;Neurologic;Neuropsychological Tests;Neuropsychology;next generation sequencing;novel;Obesity;Oral cavity;Oral health;Organ;Outcome;Participant;Pathologic;Pathway interactions;Periodontal Infection;Periodontitis;Periodontium;Peripheral;peripheral blood;Persons;Phenotype;Plasma;Population;Prevalence;Protein Isoforms;Public Health;Recording of previous events;Ribosomal RNA;Risk Factors;risk sharing;Role;Sampling;Serology;Serum;Smoking;Social Behavior;sociodemographics;Standardization;Stroke;Structure;systemic inflammatory response;tau Proteins;tau-1;Testing;therapy design;Tooth Loss;Variant;Vascular Diseases;Vascular Endothelium;Visuospatial;Washington;white matter;Work

PROJECT_TITLE: A Longitudinal Study of Periodontal Infections and Alzheimer's Disease: The WHICAP Ancillary Study of Oral Health


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pain Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Chest pain is one of this nation’s most serious and ubiquitous public health problems, yet the 12-lead ECG is only diagnostic for a small subset of patients with underlying acute myocardial infarction. We have developed and validated novel, machine learning-based, ECG interpretation algorithms that could identify patients with acute myocardial infarction, and now we aim to expand and build these intelligent models at the bedside for prospective validation and real-time clinical deployment. Deploying this system at the bedside has the potential to impact care of more than 2 million patients evaluated annually for chest pain in the US.

PI_NAMEs: AL-ZAITI, SALAH S (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Acceleration;Accident and Emergency department;Acute;acute care;Acute Coronary Event;acute coronary syndrome;Acute myocardial infarction;Admission activity;Algorithms;American;Architecture;Attenuated;Benchmarking;Biological Markers;biomarker identification;Bundle-Branch Block;Cardiac;Caring;Chest Pain;Classification;Clinical;clinical practice;clinical research site;Clinical Trials;clinically actionable;Congestive Heart Failure;Consumption;Coronary;coronary lesion;Coronary Occlusions;cost;County;Data;Data Set;Databases;Decision Support Systems;Detection;detection platform;Development;diabetic;Diagnosis;Diagnostic;Early Intervention;Electrocardiogram;Emergency Care;Emergency medical service;emergency service responder;Engineering;Enzymes;Evaluation;Event;Expert Systems;field study;Funding;graphical user interface;Hospitals;implementation barriers;improved;improved outcome;Infarction;innovation;Ischemia;iterative design;Judgment;Lead;Left Ventricular Hypertrophy;Lesion;Link;Location;Machine Learning;machine learning algorithm;Malpractice;Measurement;model building;Modeling;Monitor;mortality risk;multitask;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;North Carolina;novel;Nurses;Oranges;Outcome;pain patient;Paramedical Personnel;patient stratification;patient subsets;Patients;Pattern;Performance;Phenotype;Physicians;pilot test;prospective;prototype;Public Health;racial bias;Readiness;Recommendation;repository;risk stratification;Sampling;Sex Bias;Site;spatial integration;Syndrome;System;Testing;Time;time use;tool;Training;Translating;Troponin;Universities;usability;user centered design;Validation;ventricular hypertrophy;Work

PROJECT_TITLE: Electrocardiographic Detection of Non-ST Elevation Myocardial Events for Accelerated Classification of Chest Pain Encounters (ECG-SMART 2)

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Mobile genetic elements provide an accessory genome for microbial populations that can help microbes survive assaults such as antibiotic treatment and viral infection. The machinery encoded by such elements to promote their own transfer and maintenance provides a rich source of novel enzymes that are interesting as examples of how fundamental DNA-related manipulations can occur, and that are a potential source of new biotechnology tools. Our work focuses on the mechanistic and structural understanding of mobile element-encoded machinery, which has lagged far behind bioinformatics in this field.

PI_NAMEs: RICE, PHOEBE A (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Antibiotic Resistance;Antibiotic Therapy;Antibiotics;assault;Bacteriophages;Biochemical;Bioinformatics;Biotechnology;DNA;DNA biosynthesis;DNA glycosylase;DNA Primase;DNA-Directed DNA Polymerase;Elements;Enzymes;Epidemic;Evolution;Family;Genes;Genome;Genus staphylococcus;Health;helicase;Human;Infection;Island;Maintenance;methicillin resistant Staphylococcus aureus;Microbe;microbial;microbial genome;microbiome;Mobile Genetic Elements;novel;Pathogenicity Island;Pathway interactions;Population;Positioning Attribute;prevent;Replication Origin;Resistance;response;Role;Source;Stress;Tandem Repeat Sequences;tool;Variant;Virus Diseases;Work

PROJECT_TITLE: Machinery of the Microbial Mobilome

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project Narrative Alcohol use and related disorders are a global public health issue. According to the World Health Organization (WHO), alcohol consumption ranks as a leading risk factor for disease burden and in 2016, alcohol use resulted in 7.2% of all premature deaths, with young people being disproportionately affected. Specialized training is required to tackle this immense problem, particularly as it relates to clinical research. This proposal focuses on providing this training to pre- and postdoctoral fellows working with faculty at San Diego State University and the University of California San Diego.

PI_NAMEs: RILEY, EDWARD P (contact);SPADONI TOWNSEND, ANDREA

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: alcohol research;Modeling;Science

PROJECT_TITLE: Alcohol Research in the Science/Practitioner Model


ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Taxane based chemotherapy with docetaxel is an important treatment option for patient with metastatic prostate carcinoma. However, only about half of patients respond and resistance to therapy occurs in all patients. The goals of this proposal are to better understand the in vivo effects of taxanes, to identify biomarkers for improved patient selection, and to develop novel treatments that could extend the utility of docetaxel.

PI_NAMEs: BALK, STEVEN P. (contact);GIANNAKAKOU, PARASKEVI

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Address;androgen deprivation therapy;androgen independent prostate cancer;Binding;Biological Markers;biomarker identification;Biopsy;Cancer Patient;Castration;cell free DNA;Cell Line;Cells;chemotherapy;Clinical;clinical biomarkers;clinical care;clinical predictors;Clinical Trials;clinically significant;Computational Biology;Data;Development;digital;docetaxel;Drug resistance;Drug Targeting;Etiology;Exhibits;experience;Failure;Family;Feedback;Gene Amplification;Genes;Genetic Transcription;Genomics;Goals;improved;improved outcome;In Vitro;in vivo;in vivo Model;Investigation;knock-down;Malignant neoplasm of prostate;Mediating;member;men;Messenger RNA;Metastatic Prostate Cancer;Microtubule Bundle;Microtubule Stabilization;Microtubule-Associated Proteins;Microtubules;Mitotic;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Neoplasm Circulating Cells;novel;novel therapeutic intervention;Outcome;overexpression;patient derived xenograft model;Patient Selection;Patients;Pharmaceutical Preparations;Plasma Cells;polymerization;Polymers;pre-clinical;precision medicine;prevent;Property;Prospective Studies;protein expression;Proteins;Public Domains;Publishing;Reporting;Resistance;resistance mechanism;response;Sampling;targeted agent;taxane;Testing;Therapeutic;therapeutic development;therapy resistant;Time;transcription factor;transcriptome sequencing;transcriptomics;Translating;Tubulin;tumor;Up-Regulation;Xenograft procedure

PROJECT_TITLE: Enhancing the Efficacy of Docetaxel in Prostate Cancer


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE Tissue mechanics directly regulate numerous cell behaviors involved in development, wound healing, and disease progression. This proposal will develop biomaterials that mimic the dynamic properties of natural tissues to improve our understanding of how cells sense and integrate mechanical signals from their environment. This work should have broad implications for the development of biomaterial therapies to treat disease and promote tissue regeneration.

PI_NAMEs: CALIARI, STEVEN  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Address;Affect;Biochemical;Biocompatible Materials;Biological Models;biomaterial development;Biophysics;cell behavior;Cell Culture Techniques;Cell Differentiation process;Cell Maintenance;cell type;Cells;Complex;Cytoskeletal Modeling;design;Development;Disease;Disease Progression;Elasticity;Engineering;Environment;Exhibits;Extracellular Matrix;Fibroblasts;flexibility;Generations;Growth Factor;Harvest;Health;Hydrogels;improved;in vitro Model;Knowledge;Ligands;Liquid substance;Maintenance;mechanical behavior;mechanical properties;mechanical signal;Mechanics;mechanotransduction;mesenchymal stromal cell;migration;Process;programs;Proliferating;Property;Research;response;Signal Transduction;spatiotemporal;stem cell proliferation;stem cells;Stimulus;Testing;three dimensional cell culture;Time;tissue regeneration;Tissues;Traction;Transforming Growth Factor beta;Validation;viscoelasticity;Work;wound healing

PROJECT_TITLE: Designing cell-instructive hydrogels to understand and exploit mechanobiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Osteoarthritis;Pain Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because patients with end-stage ankle osteoarthritis are in general 10 to 15 years younger than patients suffering of knee or hip osteoarthritis, making the likelihood of patients outliving current surgical treatment options a challenging clinical problem. Our contribution here is expected to be a 3D computational study to characterize ankle joint complex osteoarthritis by quantifying anatomical shape variation through Statistical Shape Modeling of the tibiotalar and subtalar joints. This new and substantially different approach to computationally evaluate ankle morphometrics is expected to allow us to overcome the current limitations of clinical radiographic evaluation of ankle joint complex osteoarthritis, thereby opening new horizons for more quantifiable methods to aid in treatment planning for patients with end-stage ankle osteoarthritis.

PI_NAMEs: LENZ, AMY L. (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Age;age effect;Anatomy;Ankle;ankle joint;Articulation;Award;Biomechanics;Board Certification;bone;bone reconstruction;Bone remodeling;Bone Spur;calcaneum;career development;Career Mobility;Classification;Clinical;clinically relevant;Cluster Analysis;Collaborations;Complex;Computer Models;Computer software;computer studies;Data;Databases;Deformity;Degenerative polyarthritis;demographics;Diagnosis;Discrimination;Disease;Doctor of Philosophy;early-career faculty;Engineering;Ensure;Environment;Evaluation;Faculty;foot;Funding;Future;Goals;Grant;Growth;Health;Hip Osteoarthritis;Hip region structure;human old age (65+);Image;imaging scientist;Imaging Techniques;improved;Individual;individual patient;Injury;insight;Interdisciplinary Study;interest;joint destruction;joint stiffness;Joints;kinematics;Knee;Knee Osteoarthritis;Laboratory Research;Lead;Machine Learning;machine learning classification;Magnetic Resonance Imaging;Maps;mathematical model;Mathematics;Measurement;Measures;Mechanics;Medical Imaging;Mentors;Mentorship;Methods;Modeling;Morphology;Musculoskeletal;novel;Operative Surgical Procedures;Orthopedics;Outcome;Pain;pain score;Pathology;Patients;Physical Function;Population;Posture;predictive modeling;Procedures;professor;Public Health;radiological imaging;radiologist;Randomized;reconstruction;Recording of previous events;recruit;Reporting;Research;research clinical testing;Resources;Scanning;Schools;scientific computing;Scientist;Severities;Sex Differences;shape analysis;Shapes;sound;Standardization;Subtalar joint structure;Surface;Surgeon;Talus;Techniques;tibia;tool;Training;treatment planning;United States National Institutes of Health;Universities;Unnecessary Surgery;Utah;Variant;Weight-Bearing state;X-Ray Computed Tomography

PROJECT_TITLE: Classification of Ankle Osteoarthritis Severity from Weightbearing Computed Tomography Using Statistical Shape Modeling and Machine Learning

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Lung;Neonatal Respiratory Distress;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Bronchopulmonary dysplasia (BPD), or chronic lung disease of prematurity, is the most common major morbidity of premature birth. Despite an absence of clinical research evidence to support its use, the diuretic furosemide is commonly used to treat infants with severe BPD, the worst disease severity class. This proposal seeks to address fundamental knowledge gaps in our understanding of furosemide treatment strategies in severe BPD, in order to subsequently design definitive clinical trials to support or reject its use in this vulnerable infant population.

PI_NAMEs: BAMAT, NICOLAS AUGUSTO (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: absorption;Address;Admission activity;Adverse effects;Age;animal data;Award;Biological Availability;Blood;Bronchopulmonary Dysplasia;career;career development;Caring;Cessation of life;Childhood;Chronic;Chronic lung disease;Clinical;clinical efficacy;Clinical Investigator;Clinical Pharmacology;Clinical Research;Clinical Trials;comorbidity;comparative effectiveness;Complex;Data;Data Analyses;Dedications;design;Development Plans;Diagnosis;disability-adjusted life years;Disease;Diuresis;Diuretics;dosage;Dose;Drug Kinetics;Edema;Electrolytes;Ensure;Enteral;Environment;Evaluation;evidence base;Excretory function;experience;Exposure to;flexibility;Funding;Furosemide;Gases;Goals;Harm Reduction;high risk infant;Hospitalization;Hospitals;Hour;Impaired cognition;improved;improved outcome;Infant;infant outcome;innovation;instructor;Intravenous;Kidney;Knowledge;Lead;Measures;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Modeling;Morbidity - disease rate;Multicenter Trials;multidisciplinary;Neonatal;neonatal lung disease;next generation;ototoxicity;Oxygen;patient oriented research;Pediatric Hospitals;Pediatrics;Pennsylvania;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetic model;Pharmacology;Pharmacotherapy;Philadelphia;Physiological;Placebo Control;placebo controlled trial;Play;Population;Premature Birth;Premature Infant;pressure;primary outcome;programs;Prospective cohort;Pulmonary Edema;Pulmonary Hypertension;Randomized;randomized trial;Regimen;Renal clearance function;Research;Research Activity;Research Personnel;respiratory;Respiratory Disease;response;Role;Route;Safety;Sampling;Scientist;secondary outcome;Series;Severities;Severity of illness;Signal Transduction;skill acquisition;Specific qualifier value;standard care;standard of care;Stomach;Surrogate Markers;targeted delivery;Testing;Therapeutic;therapeutic target;Time;Tracheostomy procedure;Training;treatment duration;treatment strategy;United States National Institutes of Health;Universities;urinary;Urine;ventilation;years of life lost

PROJECT_TITLE: Furosemide in severe bronchopulmonary dysplasia: comparative effectiveness of a duration and dosage informed treatment strategy

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Multiple chronic conditions (e.g., diabetes, hypertension, obesity) are a costly, pervasive problem for older adults, accounting for 90% of Medicare spending. This project will test the ability of voice-controlled "smart" technology to expand the implementation and sustain the use of a proven electronic health system (Elder Tree, or ET) for these patients; specifically, we hypothesize that older adults using ET delivered by a smart system (smart speaker plus smart display) will use and benefit from ET more than patients who access ET through a laptop because the smart system enables such easy use, even by those who have a tremor, poor vision, difficulty getting to a laptop, or other side-effects of aging. If successful, this smart system-delivered eHealth intervention will make ET more accessible and effective for older patients, improve their quality of life, and point the way to more impactful delivery of future eHealth innovations.

PI_NAMEs: GUSTAFSON, DAVID H (contact);MARES, MARIE-LOUISE

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: Using Smart Devices to Implement an Evidence-based eHealth System for Older Adults

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Dietary Supplements;Nutrition;Prevention

ORG_CITY: RENSSELAER

ORG_NAME: VITAMIN D WORKSHOP

PHR: Vitamin D Workshops are international scientific conferences on the biology and health implications of vitamin D. This R13 will support five years of annual conferences to include invited talks, keynote lectures, oral communications, and poster presentations.

PI_NAMEs: WELSH, JOELLEN  (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Academia;Address;Advisory Committees;Age;age group;age related;age related chronic disease;Aging;Applications Grants;Applied Research;Area;Attention;Award;Basic Science;Biological Process;Biology;bone;bone metabolism;Calcium;calcium metabolism;Cells;Cellular biology;Cholecalciferol;Chronic;Chronic Disease;Data;design;Diabetes Mellitus;Diet;Disadvantaged;Education;Educational workshop;Ethnic Origin;Evaluation;Exposure to;Gene Expression;General Population;Genetic;Goals;Government;Grant;Health;Health Professional;Hormones;Individual;Industry;Inflammatory Bowel Diseases;Intake;interest;International;Intestines;Kidney;lectures;Life Cycle Stages;Light;Malignant Neoplasms;Medicine;meetings;Metabolism;Minority;Mission;Molecular;Multiple Sclerosis;Nuclear Receptors;oral communication;Outcome;Participant;Pathologic Processes;Peer Review;Physiological;Policy Maker;Population;Population Group;Population Heterogeneity;posters;prevent;Production;programs;Publications;Research;research and development;Research Personnel;Resources;Role;Scholarship;scientific organization;Scientist;Series;Serum Markers;Skin;steroid hormone;Suggestion;Supplementation;symposium;Tissues;translational scientist;Travel;Ultraviolet Rays;Vitamin D;Vitamin D Deficiency;Vitamin D supplementation;Vitamin D2;Vitamin D3 Receptor

PROJECT_TITLE: Annual Vitamin D Workshops


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

PHR: Project Narrative Translational control is critical for a variety of cellular processes and its dysregulation has been shown to disrupt development and cause many human diseases. Yet the molecular mechanisms that modulate translation, particularly in stem cells, are largely unknown. To achieve a comprehensive understanding of translational control networks, I propose to 1) develop a screening approach for studying translation that combines CRISPR with polysome profiling; 2) apply this approach to discover pathways that regulate global translation levels in stem cells; and 3) investigate selective mRNA translation using ribosome profiling.

PI_NAMEs: JOUNG, JULIA  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Affect;Biogenesis;Candidate Disease Gene;Cell Physiology;cell type;Clustered Regularly Interspaced Short Palindromic Repeats;Code;CRISPR screen;Data;Development;Disease;Fibroblasts;FRAP1 gene;gene discovery;gene interaction;Genes;Genetic;Genetic Screening;genome-wide;Guide RNA;Homeostasis;human disease;human embryonic stem cell;Immunoprecipitation;Investigation;knock-down;Libraries;Literature;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Messenger RNA;Methods;MicroRNAs;Molecular;mRNA Translation;Nucleic Acid Regulatory Sequences;Open Reading Frames;Pathway interactions;Peptide Initiation Factors;pluripotency;Polyribosomes;polysome profiling;preservation;Process;Protein Biosynthesis;protein expression;Proteins;Publishing;Regulatory Element;Regulatory Pathway;Reporter;Reporter Genes;ribosome profiling;Ribosomes;RNA-Binding Proteins;screening;Screening Result;Site;stem cell function;stem cells;Testing;Translating;translational potential;Translational Regulation;Translational Repression;Translations;Untranslated Regions;vector;Work

PROJECT_TITLE: Deciphering Translational Control in Stem Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]