NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Patient Safety;Prevention;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE Women affected by genital fistula experience significant physical and psychosocial morbidity associated with the condition, and nascent evidence suggests subsequent adverse outcomes occur after surgical repair (i.e., fistula repair breakdown or recurrence and incontinence). To identify salient targets for clinical and counselling interventions to improve women’s health and quality of life following fistula repair, we seek to understand the contribution of individual, fistula-related, and post-repair behaviors and exposures to these adverse outcomes. Subsequent and iterative work with key stakeholders will help us develop a road map of intervention strategies likely to be feasible and acceptable within the study population and setting.

PI_NAMEs: EL AYADI, ALISON M (contact)

PROGRAM_OFFICER_NAME: MAZLOOMDOOST, DONNA

PROJECT_TERMS: acceptability and feasibility;Accounting;Address;adverse outcome;Affect;Africa South of the Sahara;Attention;Behavior;Behavioral;Behavioral Sciences;care providers;Cervical spinal cord injury;Characteristics;Clinical;clinical care;clinical development;clinical examination;cohort;Coitus;Communities;contextual factors;Counseling;Data;Development;Economics;Enrollment;evidence base;experience;Exposure to;Extravasation;Face;Family;Feces;Female genitalia;Fistula;follow-up;frailty;Genitalia;hazard;Health;hip bone;Iatrogenesis;implementation science;improved;Incidence;Incontinence;Individual;Infection;Injury;Intervention;intervention mapping;Interview;Joints;Knowledge;Longitudinal cohort;Longitudinal cohort study;longitudinal design;marginalization;Medical Records;member;Methods;Modeling;Morbidity - disease rate;nerve damage;Obstructed labor;Operative Surgical Procedures;Outcome;Pain;Participant;Patients;Personal Satisfaction;Physical Examination;physical symptom;Population;Pregnancy;Pregnancy Complications;Pregnancy Outcome;prevent;Prevention;Process;psychosocial;Quality of life;Questionnaires;recruit;Recurrence;Religion;repaired;Reporting;Research;Research Infrastructure;Resolution;Risk;Risk Factors;Role;Sample Size;Sampling;secondary infertility;Severities;Site;social;sociodemographics;standard of care;Stigmatization;stillbirth;Structure;study population;Survival Analysis;Symptoms;Testing;theories;Theory of Change;Time;Translating;Translations;Trauma;Uganda;Urinary Incontinence;Urine;Validation;Walking;Woman;Women's Health;women's outcomes;Work

PROJECT_TITLE: Identifying Opportunities for Prevention of Adverse Outcomes Following Female Genital Fistula Repair

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: DE

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CAMBRIDGE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

ORG_STATE: MA

PHR: Project Narrative Sjӧgren’s syndrome-associated xerostomia greatly compromises the oral health and the quality of life of 2-4 million Americans because of devastating loss of saliva and severe dry mouth. SS is an autoimmune disease and destruction of the salivary glands, and failure of therapies to restore their function, is the result of our inability to control autoimmune inflammation. Completion of this proposed project will contribute to the development of effective and targeted therapeutic strategies to fundamentally restore salivary gland integrity and function.

PI_NAMEs: ZHOU, JING  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Acinar Cell;Affect;Aging;American;attenuation;Autoimmune;Autoimmune Diseases;autoimmune inflammation;autoimmune pathogenesis;autoinflammation;autoreactive T cell;autoreactivity;Cell Compartmentation;cell type;Cells;Characteristics;chronic autoimmune disease;Clinical;Complex;Cytotoxic T-Lymphocytes;Data;Development;Disease;draining lymph node;Duct (organ) structure;effective therapy;Equilibrium;Exhibits;Face;fatty acid oxidation;Food deprivation (experimental);FOXP3 gene;Gene Expression Profile;Genes;Genetic Engineering;Gland;Goals;Grant;High-Throughput RNA Sequencing;Immune;immunoregulation;improved;Inbred NOD Mice;Inflammation;Inflammatory;Injury;insight;Intermittent fasting;Link;Literature;Mediating;Modeling;Molecular;mouse model;Mouse Strains;Mus;Natural regeneration;new therapeutic target;notch protein;novel therapeutics;Oral health;palliative;Palliative Care;Pathogenesis;Pathway interactions;Periodicals;Peroxisome Proliferator-Activated Receptors;Pharmaceutical Preparations;prevent;progenitor;Proliferating;Quality of life;Radiation;regenerative;Regenerative capacity;Regimen;Regulation;Reporting;response;restoration;Saliva;saliva secretion;Salivary;Salivary duct structure;Salivary Glands;Serum;Signal Transduction;Sjogren's Syndrome;Source;stem cell based approach;stem cells;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testing;tissue regeneration;Tissues;Treatment Failure;Water;Xerostomia

PROJECT_TITLE: Intermittent fasting restores salivary gland function in Sjögren’s syndrome


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Disability Research;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation

ORG_CITY: BALTIMORE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Neural prostheses are able to deliver reliable and efficient functional excitation of the nervous system to enable technology such as cochlear implants, retinal implants, pacemakers, spinal cord stimulators, and deep brain stimulators. Conversely, suppression of the nervous system is not easily achieved. The central goal of this project is to advance the technology toward achieving efficient suppression of the nervous system and to improve the application of neural prostheses for the treatment of vestibular balance disorders.

PI_NAMEs: DELLA SANTINA, CHARLES C;FRIDMAN, GENE YEVGENY (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: 3-Dimensional;Acute;Advanced Development;Animal Model;Artificial Implants;Authorization documentation;Basic Science;behavioral study;Bilateral;Biological;Biological Assay;Catheters;Characteristics;Charge;Chinchilla (genus);Chronic;Clinical;Cochlear Implants;Corrosion;Darkness;Data;deep brain stimulator;design;Development;Device or Instrument Development;Devices;disabled;Drops;Ear;Electrodes;Engineering;equilibration disorder;Esthesia;Evaluation;first-in-human;Foundations;Frequencies;Future;Gel;Goals;Hair Cells;Head;Histologic;Human;Hydrolysis;Implant;implantation;improved;Injections;Institution;instrument;Labyrinth;Lead;Metals;Microfluidics;Monkeys;Motion;Nervous System;neural;neural implant;neural prosthesis;Neurons;neuroprosthesis;neuroregulation;nonhuman primate;novel;Operative Surgical Procedures;Outcome;Pacemakers;Performance;Phase;Physiologic pulse;Physiological;pre-clinical;Preparation;Primates;Prosthesis;Protocols documentation;prototype;Reaction;Research;response;retina implantation;Rotation;Safety;Saline;Scheme;Spinal Cord;Stimulus;System;Technology;Testing;Therapeutic;Tissues;Translating;Translational Research;Translations;Tube;United States Food and Drug Administration;Vestibular dysfunction;Vestibular Hair Cells;Vestibular loss;Vestibular Nerve;vestibular prosthesis;vestibular system;vestibulo-ocular reflex;wireless;Work

PROJECT_TITLE: Modulation of the Vestibular System Using Prosthetic Direct Current Stimulation

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_DEPT: VETERINARY SCIENCES

PHR: Project Narrative This renewal of our Cooperative Agreement (U42OD013117) requests four years of funding to continue support for a Specific Pathogen Free (SPF) colony of healthy, behaviorally normal, major histocompatibility complex (MHC) profiled pig-tailed macaques (Macaca nemestrina) at the Johns Hopkins University. Since 2016, our colony has produced an average of 51 offspring each year and we have sold an average of 32. At least 50% of colony-produced juvenile males, and increasing numbers of juvenile females, are sold to NIH- funded investigators outside of Johns Hopkins for HIV/AIDS related research, demonstrating the colony's status as a national resource.

PI_NAMEs: HOPPER, LYDIA  (contact);MANKOWSKI, JOSEPH L

PROGRAM_OFFICER_NAME: SUI, YONGJUN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adolescent;animal breeding;Animal Sources;Animals;Area;Behavioral;Biological Assay;Breeding;Cercopithecine Herpesvirus 1;Country;deep sequencing;Disease;Female;functional genomics;Funding;genetic pedigree;Genome;Genomic approach;Genotype;germ free condition;Goals;Grant;health data;Histocompatibility;HIV;HIV/AIDS;improved;Institution;interest;Life;Macaca;Macaca nemestrina;Major Histocompatibility Complex;male;Modeling;offspring;operation;Population;preservation;Primates;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Sales;screening;Serology;Simian Retroviruses;SIV;Testing;U-Series Cooperative Agreements;United States;United States National Institutes of Health;Universities;Viral;Virus

PROJECT_TITLE: Continued support for an SPF Macaca nemestrina breeding colony to provide animals to NIH funded HIV research projects

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-J(52)]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PI_NAMEs: HOPPER, LYDIA  (contact)

PROJECT_TERMS: access restrictions;Affect;Animal Sources;Animals;Applications Grants;Behavioral;Bibliography;Brain;Breeding;Caring;Characteristics;Disease;Embryology;Female;Funding;Genetic;genetic pedigree;Genotype;Goals;Grant;health data;Health Status;HIV;HIV/AIDS;Housing;Immunity;Income;Institution;Macaca nemestrina;Maintenance;male;Modeling;offspring;Personality;Production;programs;PubMed;Research;Research Personnel;Research Project Grants;Sales;serotonin transporter;sex;SIV;Social Environment;Source;Testing;United States;United States National Institutes of Health;Universities;Viral;Virus Diseases

PROJECT_TITLE: Husbandry Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-J]


PI_NAMEs: MANKOWSKI, JOSEPH L (contact)

PROJECT_TERMS: Animals;Biological Assay;Biomedical Research;Breeding;Cercopithecine Herpesvirus 1;Communities;Development;Funding;germ free condition;Goals;HIV;HIV/AIDS;Infant;Laboratories;Life;Macaca;Macaca nemestrina;Maintenance;Modeling;Primates;Quarantine;Reproducibility;Research;Research Project Grants;Resources;Serology;Simian Retroviruses;SIV;Source;Supervision;Testing;United States National Institutes of Health;Universities;Viral;Virus;virus testing

PROJECT_TITLE: Viral Testing Core


PROJECT_TERMS: Address;Alleles;animal breeding;Animals;Breeding;Central Nervous System Diseases;Collaborations;Data;deep sequencing;functional genomics;Funding;Genetic;Genome;Genomic approach;Genotype;Goals;Haplotypes;HIV;HIV Infections;Immunogenetics;Immunologist;improved;Knowledge;knowledge base;Macaca;Macaca mulatta;Macaca nemestrina;medical schools;MHC Class I Genes;MHC Class II Genes;Modeling;neuroprotection;next generation sequencing;nonhuman primate;novel;Primates;professor;Publishing;Reproducibility;Research;Research Project Grants;Resources;Role;Sampling;SIV;Technology;tool;transcriptomics;United States National Institutes of Health;Universities;Update;Wisconsin;Work

PROJECT_TITLE: MHC GENETIC TYPING CORE


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ALBANY

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

ORG_STATE: NY

PHR: Project Narrative The spinocerebellar ataxias (SCAs) are a large group of rare neurological disorders characterized by lack of balance and coordination that causes clumsy voluntary movements. Our preliminary data and lessons learned from other repeat expansion disease suggest disruptions to the transcriptome, including to alternative splicing, may be a novel hallmark of SCAs, which would have important implications for tracking disease and developing therapies. Here we will test if targeting the repeat expansion mutation that underlies many of these SCAs will provide therapeutic potential across multiple diseases and whether cross-disease therapeutic efficacy can be quantified by measuring changes in alternative splicing.

PI_NAMEs: BERGLUND, ANDREW  (contact);SHIN, DAMIAN SEUNG-HO;SHORROCK, HANNAH

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Acceleration;Address;Alternative Splicing;Animals;Ataxia;behavioral phenotyping;Biological Availability;Biological Markers;Cell Line;clinic ready;Clinical Trials;Data;Degenerative Disorder;Development;differential expression;Disease;Disease Outcome;Equilibrium;Event;experience;FDA approved;Fibroblasts;Future;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Genomics;Human;improved;in vivo evaluation;Induced pluripotent stem cell derived neurons;Inherited;insight;Investigation;Lead;lead candidate;Link;Longitudinal Studies;Measures;Microsatellite Repeats;MJD1 protein;Molecular;mouse model;Movement;Mus;Mutation;Myotonic Dystrophy;Natural Products;Nervous System Disorder;Neuronal Dysfunction;Neurons;new therapeutic target;novel;novel marker;Onset of illness;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;polyglutamine;Population;pre-clinical therapy;preclinical efficacy;preclinical study;Production;Proteins;Publishing;ratiometric;Reporter;research clinical testing;Reverse Transcriptase Polymerase Chain Reaction;RNA;RNA Splicing;Safety;screening;small molecule;small molecule libraries;small molecule therapeutics;Spinocerebellar Ataxias;System;Testing;Therapeutic;therapeutic biomarker;therapeutic development;therapeutic evaluation;therapy development;Time;Tissue-Specific Gene Expression;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Treatment Efficacy;Western Blotting;Work

PROJECT_TITLE: Alternative Splicing and Development of Small Molecule Therapeutics in CAG Expansion Spinocerebellar Ataxias

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: CA

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Prevention

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Robert A. Saxton | K22 (PAR-18-467) | Project Narrative  IL-20 family cytokines are pleiotropic immune cell-derived factors that are upregulated in inflammation and have been implicated in the occurrence of inflammation associated tumorigenesis. The proposed research aims to interrogate the diverse functions of these cytokines by engineering IL-20 receptor agonists with altered receptor specificity and signaling profiles, enabling us to deconvolute their functional effects in a mouse model of colitis-associated cancer. These studies will provide insights into the therapeutic potential of these engineered cytokines in the treatment and prevention of inflammation-associated cancers.

PI_NAMEs: SAXTON, ROBERT ANDREW (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Adrenal Cortex Hormones;Affinity;Agonist;alternative treatment;antagonist;anti-tumor immune response;autoinflammatory diseases;Binding;Binding Sites;Biological Assay;Biophysics;cancer type;Cell Line;Cells;Chronic;chronic inflammatory disease;Colitis;colitis associated cancer;Colon;Colon Carcinoma;combinatorial;Complex;cytokine;Development;dextran sulfate sodium induced colitis;Directed Molecular Evolution;Disease;Engineering;Environment;Epithelial Cells;Epithelium;Esophageal Tissue;Esophagus;experimental study;Family;Gastrointestinal tract structure;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Homeostasis;Immune;Immune system;Immunologic Surveillance;Immunosuppressive Agents;In Vitro;in vivo;Incidence;Individual;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;insight;interleukin 20;interleukin-19;Interleukin-24;Intestines;Laboratories;Large Intestine Carcinoma;Ligands;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;member;Monitor;Mucous Membrane;murine colitis;Mus;mutant;Nature;novel;Organism;Organoids;Pathogenicity;Pathology;Pathway interactions;Patients;pharmacologic;Play;pleiotropism;Predisposition;Prevention;Production;Protein Engineering;receptor;Receptor Signaling;Regimen;repaired;Research;response;Risk;Risk Factors;Role;Severity of illness;Signal Transduction;Site;Skin;Specificity;Structure;Surface;Therapeutic;therapeutic evaluation;Tissues;tool;transcriptome sequencing;treatment strategy;Triage;tumor;tumor initiation;tumor progression;Tumor Promotion;tumorigenesis;Up-Regulation;Variant;variant of interest;Yeasts

PROJECT_TITLE: Decoding the functional pleiotropy of IL-20Rβ ligands in inflammation and tumorigenesis


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_CITY: ROCKVILLE

ORG_NAME: MESO SCALE DIAGNOSTICS, LLC

PHR: When caring for neonates with hypoxic-ischemic encephalopathy (HIE), neonatologists lack sufficient tools to assess severity of brain damage or monitor response to therapy. This proposal seeks to analytically validate a highly sensitive and specific research-use only blood immunoassay for objectively measuring the extent of brain injury caused by HIE. All critical components for the assay will be carefully characterized, three kit lots will be manufactured, and the immunoassay will be evaluated at three different sites. Long-term, the assay will help to stratify neonates with HIE for clinical trials of investigational adjuvants to therapeutic hypothermia and enable personalized treatments tailored to the severity of injury.

PI_NAMEs: STENGELIN, MARTIN  (contact)

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: Acceleration;Adjuvant;Adjuvant Study;Affect;Analysis of Variance;Animal Model;Asphyxia;Biological Assay;Biological Markers;Biometry;Birth;Blood;Blood Tests;Body System;Brain Injuries;Caring;Cause of Death;Cerebral Palsy;Certification;Cessation of life;Child;Clinical;Clinical Chemistry;Clinical Treatment;Clinical Trials;Clinical Trials Design;clinically relevant;Collaborations;cross reactivity;Data;data submission;design;Development;Diagnostic;disability;Effectiveness;Ensure;Enzyme-Linked Immunosorbent Assay;Evaluation;Freezing;functional outcomes;Funding;Glial Fibrillary Acidic Protein;Goals;Guidelines;Heterogeneity;Hospitals;Hour;Immunoassay;improved;improved outcome;Individual;individualized medicine;Industrialization;Industry;Injury;innovation;instrument;Laboratories;Life;Lifelong disability;Magnetic Resonance Imaging;manufacturability;manufacture;Measurement;Measures;Medicine;Methods;Monitor;Multi-Institutional Clinical Trial;multiplex assay;natural hypothermia;neonatal hypoxic-ischemic brain injury;Neonatal Intensive Care Units;neonate;Nervous System Trauma;neuroimaging;Neurological outcome;novel;Outcome;outcome prediction;Participant;Pediatric Hospitals;Performance;Perinatal;personalized medicine;Phase;Plasma;predicting response;Predisposition;Process;Prognosis;programs;Prospective Studies;Protocols documentation;Qualifying;Reagent;Recovery;Reporting;Reproducibility;Research;research clinical testing;Risk;Running;Sampling;screening;Serum;Severities;Site;stability testing;Survivors;System;Target Populations;tau Proteins;Testing;Therapeutic;Time;tool;Treatment Effectiveness;treatment response;United States National Institutes of Health;Universities;Validation;validation studies

PROJECT_TITLE: Blood test to aid treatment decisions for perinatal asphyxiation

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Obesity

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Type 2 diabetes (T2D) and non alcoholic fatty liver disease (NAFLD) are emerging as two of the most critical global health challenges of the 21st century and there is a great unmet need for new therapies. This grant will provide essential safety and efficacy data for a novel class of drugs for NAFLD and T2D in non human primates.

PI_NAMEs: SHULMAN, GERALD I (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acetyl Coenzyme A;Adipocytes;Affect;Behavior;Body Composition;Body Weight;Body Weight decreased;Caloric Restriction;Cell secretion;ceramide kinase;Chronic;clinically relevant;Closure by clamp;cohort;controlled release;cytokine;Data;design;Development;Diacylglycerol Kinase;Diglycerides;Disease Resistance;Eating;efficacy evaluation;Fatty acid glycerol esters;fatty acid oxidation;Fatty Liver;General Population;Generations;global health;Gluconeogenesis;Glucose;Glucose Clamp;glucose production;Glycerol;Grant;Hepatic;Human;human model;Hyperinsulinism;Hypertriglyceridemia;improved;Induced Hyperthermia;Insulin;Insulin Resistance;insulin sensitivity;intravenous glucose tolerance test;ketogenesis;Lipids;Liquid Chromatography;Liver;liver biopsy;Liver Fibrosis;Liver Mitochondria;Macaca mulatta;Measurement;Measures;Mediating;Metabolic;Metabolic syndrome;Methodology;Methods;Mitochondria;Modeling;Monitor;Monkeys;Muscle;NMR Spectroscopy;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;nonhuman primate;novel;novel drug class;novel therapeutic intervention;novel therapeutics;Obesity;Oral;oxidation;Palmitates;Pathogenesis;Placebos;Plasma;Predisposing Factor;protein activation;protein kinase C epsilon;Pyruvate Carboxylase;pyruvate dehydrogenase;Pyruvate Kinase;Research;Rodent;Rodent Model;Safety;side effect;stable isotope;Steatohepatitis;Structure of beta Cell of islet;success;Syndrome;systemic toxicity;tandem mass spectrometry;Therapeutic Agents;Therapeutic Index;Tissues;Tracer;treatment strategy;Triglycerides;Uncoupling Agents

PROJECT_TITLE: Development of Controlled Release Mitochondrial Protonophore (CRMP) as a Novel Treatment for Type-2 Diabetes and Non-Alcoholic Steatohepatitis in Dysmetabolic Non-Human Primates


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and a better understanding of the molecular mechanisms driving HCC will improve therapeutic developments. My proposal investigates an understudied mechanism in HCC I recently discovered where IQGAP1, a scaffold protein, promotes oncogenic YAP1 signaling. Additionally, I propose the engineering of a humanized HCC model; which can be applied to study various oncogenes, and used as a tool to validate and test precision based therapies.

PI_NAMEs: DELGADO, EVAN R (contact)

PROGRAM_OFFICER_NAME: VAHEDI, SHAHROOZ

PROJECT_TERMS: Acceleration;Animal Model;Automobile Driving;BAY 54-9085;beta catenin;Binding;Biological;Biological Assay;Biology;Cancer Etiology;career;Cell Proliferation;Cells;Cessation of life;Chemicals;combat;Complex;Data;Development;Disease;Disease Management;disease model;Engineering;Environment;experience;Fluorescence Resonance Energy Transfer;Future;Genes;Genetic;genetic signature;Genomics;Goals;Growth;Hepatocyte;Human;human disease;Human Genetics;humanized mouse;Image;improved;in vitro activity;in vivo Model;inhibitor;Injections;innovation;insight;lentivirally transduced;Lentivirus;Link;Liver;liver cancer model;Luciferases;Measures;Mediating;Methods;Modeling;Molecular;Mus;mutant;Mutation;novel;Nuclear;Nuclear Translocation;Oncogenes;Oncogenic;Organ Donor;Organ Transplantation;overexpression;Pathology;patient derived xenograft model;Patients;Pattern;personalized medicine;personalized therapeutic;phase I trial;Phosphotransferases;pre-clinical;Pre-Clinical Model;Preclinical Drug Development;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;promoter;Public Health;Quantitative Reverse Transcriptase PCR;Receptor Protein-Tyrosine Kinases;Reporter;Reproducibility;Research;Research Design;Research Personnel;Resources;Role;Scaffolding Protein;Severities;Signal Transduction;Sleeping Beauty;small hairpin RNA;Study models;System;Tail;targeted treatment;Techniques;Testing;Therapeutic;therapeutic development;Time;tool;transcriptome sequencing;transcriptomics;Translating;Translations;Transplantation;tumor;Tumor Burden;tumor growth;tumorigenesis;United States;Universities;Veins;Viral;Western Blotting;Work;Xenograft procedure

PROJECT_TITLE: Investigating IQGAP1, a scaffold protein, in liver biology and Hepatocellular Carcinoma to overcome barriers in in vivo models

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Bioengineering;Data Science;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

ORG_STATE: WA

PHR: This proposal seeks to build a comprehensive user support and dissemination platform for our recently developed powerful software tools that facilitate many aspects of modeling in neuroscience. These tools include the Brain Modeling ToolKit (BMTK) software suite for model building/simulation and the SONATA file format for efficient storage of model and simulation data, both developed at the Allen Institute, as well as the visualization software integrated with SONATA, developed at the University of Illinois. With appropriate user support and dissemination, these tools will facilitate sophisticated modeling work as well as model exchange and reproducibility, contributing to the BRAIN Initiative’s priority areas of Theory and Data Analysis and Integrated Approaches and promoting FAIRness (Findability, Accessibility, Interoperability, and Reuse of digital assets) in neuroscience modeling.

PI_NAMEs: ARKHIPOV, ANTON  (contact);TAJKHORSHID, EMAD

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: Address;Area;base;Behavior;Biophysics;Brain;BRAIN initiative;Brain region;Cells;Code;Communities;Complex;complex modeling;Computer software;Data;Data Analyses;data exchange;data format;data integration;data modalities;Databases;Dedications;digital;diverse data;Documentation;Educational workshop;European;experimental study;FAIR principles;Feedback;file format;flexibility;Goals;Graph;graphical user interface;Human;Illinois;interest;Intuition;Language;Literature;Manuscripts;model building;Modeling;models and simulation;Molecular;movie;multimodal data;network architecture;network models;Neurons;Neurosciences;Output;Personal Computers;Persons;Population Dynamics;Population Statistics;Property;public database;Publications;Reproducibility;Resolution;Resources;response;Running;scripting interface;simulation;Software Tools;Structure;theories;tool;Training;Universities;user-friendly;Vision;Visual;Visualization;Visualization software;Work

PROJECT_TITLE: Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE In the United States (US), the higher prevalence and mortality of type 2 diabetes mellitus (T2DM) in rural compared to urban populations represents a major public health problem. The proposed research focuses on the rural Midwest and leverages institutional resources and a multidisciplinary team of mentors and advisors to (1) characterize diabetes epidemiology; (2) evaluate the associations of traditional and novel rural-enriched risk factors with incident T2DM; and (3) develop a rural-specific self-administered T2DM risk score through patient engagement. This study has the potential to support efforts to prevent T2DM, improve T2DM care, and reduce T2DM health disparities for Midwest rural populations.

PI_NAMEs: DUGANI, CHANDRASAGAR  (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Address;Adult;Age;age group;American;Award;Behavior Therapy;Behavioral;Behavioral Risk Factor Surveillance System;biobank;Biological Markers;Caring;Centers for Disease Control and Prevention (U.S.);Clinic;Clinical Investigator;Clinical Trials;cohort;Communities;County;Data;Data Science;Death Rate;Dedications;demographics;Development;diabetes control;Diabetes Mellitus;diabetes risk;Diet;Epidemiology;Ethnic Origin;experience;Exposure to;Focus Groups;Gender;Goals;health care availability;Health Disparities Research;health disparity;Health Insurance;Health Services Research;High Prevalence;high risk;Hospital Mortality;Hospitalists;improved;Incentives;Incidence;Inequality;Infrastructure;Institution;interest;Intervention;Knowledge;Laboratories;Lead;Leadership;Life Style;Master of Public Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Midwestern United States;Minority Groups;mortality;multidisciplinary;National Institute on Minority Health and Health Disparities;Non-Insulin-Dependent Diabetes Mellitus;novel;Organic Chemicals;Outcome;patient engagement;patient oriented;patient oriented research;Patient risk;Patient Self-Report;Patients;Persons;Pesticides;physical inactivity;Population;prevent;Prevention strategy;Primary Prevention;programs;prospective;Public Health;Questionnaires;Race;Reduce health disparities;regional difference;Research;Research Design;Research Methodology;Research Personnel;Resources;Risk;Risk Factors;risk prediction;Rural;rural area;Rural Community;rural counties;rural dwellers;rural health disparities;rural patients;Rural Population;rurality;Self Administration;skills;Socioeconomic Status;socioeconomics;Surveys;System;telephone based;Telephone Interviews;Testing;Time trend;Training;type I and type II diabetes;United States;United States National Center for Health Statistics;United States National Institutes of Health;urban area;Urban Population;Work

PROJECT_TITLE: Rural Patient Risks and Exposures for Diabetes ConTrol (Rural PREDICT)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Narrative Understanding the unique mechanisms that govern germ cell formation and function will have a positive impact on medical science. We seek to gain new insights into the molecules that control germ cell differentiation and how germ cells protect the integrity of their genomes.

PI_NAMEs: BUSZCZAK, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adopted;Area;Back;Biogenesis;Cell Differentiation process;Cell Physiology;Cells;Cellular biology;CRISPR/Cas technology;Cytoplasm;Cytoprotection;Development;Dissection;DNA Repair;DNA Transposable Elements;Drosophila genome;Drosophila genus;Embryonic Development;epigenome;Exhibits;fascinate;Foundations;Genes;Genetic;Genome;Genome Stability;Germ cell tumor;Germ Cells;Gonadal structure;Hand;Haploidy;Health;Human;innovation;insight;Medical;Meiosis;Methods;Modeling;Molecular;mRNA Translation;Mutate;Mutation;Nuclear;Ovary;Pathway interactions;Peptide Hydrolases;Phenotype;Process;programs;Regulation;Ribosomes;Science;screening;Shapes;Small RNA;Solid;tool;Totipotency;Work

PROJECT_TITLE: Genetic Dissection of Germ Cell Differentiation and Function

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Hematology;Infectious Diseases;Prevention;Sepsis

PHR: PROJECT NARRATIVE Central venous catheters are essential healthcare devices used for a range of applications from hemodialysis to critically ill patients. Unfortunately, these catheters have a propensity to become colonized with microorganisms, which can result in a serious and sometimes life-threatening condition called “central line-associated bloodstream infection” or “CLABSI”. We propose to develop an antibiotic-free approach to prevent CLABSI using an innovative electrochemical catheter that generates continuous, low concentrations of the biocide hypochlorous acid in its lumen.

PI_NAMEs: BEYENAL, HALUK ;PATEL, ROBIN  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Acinetobacter baumannii;Address;Animal Model;Animal Testing;Animals;anti-microbial drug;Antibiotics;antimicrobial;Bacteria;Bacterial Drug Resistance;Biocide;Blood Cells;Blood Circulation;breakthrough infection;Candida;Candida albicans;Candida auris;Caring;catheter related infection;Catheters;cell growth;Clinical;commensal microbes;COVID-19 pandemic;COVID-19 patient;Critical Illness;Custom;Death Rate;design;Devices;Drug resistance;emerging antibiotic resistance;Enterobacter cloacae;Enterococcus faecium;Escherichia coli;Experimental Animal Model;Functional disorder;Generations;Healthcare;Hemodialysis;Hour;Human;Hypochlorous Acid;In Vitro;in vitro Model;Infection;Infection prevention;infection rate;innovation;Klebsiella pneumoniae;Laboratories;Length of Stay;Life;Liquid substance;Local Anti-Infective Agents;medication administration;microbial;Microbial Biofilms;microbial colonization;microorganism;Modeling;mortality;novel;Oryctolagus cuniculus;Parenteral Nutrition;pathogen;Patients;Pharmaceutical Preparations;pressure;prevent;Prevention;Prevention approach;Prevention strategy;Pseudomonas aeruginosa;Reaction;Reporting;Route;Sepsis;Site;Source;Staphylococcus aureus;Staphylococcus epidermidis;Surface;System;Techniques;Testing;Toxic effect;Vascular Endothelial Cell;Venous;Work;Yeasts

PROJECT_TITLE: Electrochemical Catheter for Prevention of Central Line-Associated Bloodstream Infection

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Peripheral artery disease (PAD) represent a major cause of cardiac and limb morbidity and all-cause mortality in Western society. Emerging data from our group indicate the importance of platelet activity and platelet's non-hemostatic role in the regulation of PAD, yet this is an understudied area. Our work aims to fill this void by investigating the role of platelets in PAD and other phenotypes of vascular disease, and the molecular mechanisms by which coding and noncoding RNAs regulate platelet activity and influence the pathogenesis of PAD and its consequences, with the ultimate goal of identifying novel prognostic/diagnostic approaches and therapeutic targets for the treatment and prevention of vascular disease.

PI_NAMEs: BERGER, JEFFREY S (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Abdominal Aortic Aneurysm;advanced system;Amputation;Animal Model;Area;Aspirin;Blood Platelets;Blood Vessels;Candidate Disease Gene;Cardiac;Cardiovascular system;Carotid Stenosis;Clinical;clinical biomarkers;Code;cohort;Collection;Complex;Coronary Arteriosclerosis;cost;Data;design;diagnostic strategy;Disease;Effectiveness;Effector Cell;Event;follow-up;Fostering;Functional disorder;Goals;Heart;Incidence;Inflammation;insight;International;Knock-in;Knock-out;Leukocytes;Life;Limb structure;Lower Extremity;Medical;Megakaryocytes;Molecular;monocyte;Morbidity - disease rate;mortality;Myocardial Infarction;new therapeutic target;novel;Pathogenesis;Patients;Peripheral arterial disease;Persons;Phenotype;Platelet aggregation;platelet phenotype;Play;Positioning Attribute;Post-Transcriptional Regulation;prevent;Prevention;Procedures;Process;prognostic;Property;Regulation;Research Design;Role;Sampling;Severities;Societies;Therapeutic;therapeutic target;Transcript;transcriptome;United States;Untranslated RNA;Vascular Diseases;Work

PROJECT_TITLE: Mechanisms of Platelet Activity in Vascular Disease


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Non-communicable diseases account for 71% of all deaths globally, yet training opportunities for research in global cardiovascular, cardiometabolic, pulmonary, and hematologic diseases are limited. The proposed research training program is designed to fill this gap and provide pathways for post-doctoral clinical fellows to contribute to these critical fields. The program will provide fellows with in-depth research training, professional development, and high-quality mentorship; emphasis will be placed on enhancing diversity in the workforce, as well as achieving equity in global health partnerships

PI_NAMEs: HABERER, JESSICA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, MAKEDA J

PROJECT_TERMS: Disease;Research Training

PROJECT_TITLE: Research Training in Global Non-Communicable Diseases

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The HARMONY study will test the effects of a culturally-tailored mindfulness self-management intervention on sustained improvements in healthy eating and exercise through improved mindful stress management, self- regulation, and self-efficacy in overweight African American women at risk for chronic cardiometabolic illness.

PI_NAMEs: GAYLORD, SUSAN ;GISCOMBE, CHERYL L (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: 18 year old;actigraphy;Address;Adherence;Adopted;Adult;Affect;African American Women;allostatic load;American;arm;attentional control;Behavioral;Biological Markers;Body fat;Body mass index;C-reactive protein;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;caregiving;Chronic;Chronic disability;Chronic Disease;Chronic stress;Cognitive;Communities;community advisory board;Community Health;community setting;cytokine;Death Rate;depressive symptoms;design;Diabetes Mellitus;Diet;dietary;Disparity;disparity reduction;Distress;Eating;Eating Behavior;Educational process of instructing;Emotional;Ethnic Population;Exercise;experience;Exposure to;feasibility research;fruits and vegetables;Gender;Goals;Health;health disparity;Healthy Eating;healthy lifestyle;High Risk Woman;implementation facilitation;improved;Inflammatory;Informal Social Control;Intake;Intervention;intervention effect;Life;lifestyle intervention;loved ones;Measures;Mediating;Mediator;men;mindfulness;mindfulness intervention;Mindfulness Training;nutrition;nutrition education;Obesity;Outcome;Overweight;Participant;Patient Self-Report;perceived stress;physical inactivity;Physiology;Posture;Psychological Stress;Quality of life;Questionnaires;Race;racial population;Randomized;Randomized, Controlled Trials;Research;resilience;response;Risk;Risk Assessment;Risk Factors;Risk Reduction;Self Care;Self Efficacy;Self Management;self reliance;social culture;sociodemographic group;Stress;stress management;stress reduction;stressor;Stroke;success;Testing;United States National Institutes of Health;Waist-Hip Ratio;White Women;Woman;women versus men;Women's Group;Work

PROJECT_TITLE: THE HARMONY Study - A culturally-relevant, randomized-controlled, stress management intervention to reduce cardiometabolic risk in African American women.

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative This R25 application supports an innovative skills development program to educate oncology professionals including Nursing, Social Work and Chaplaincy to meet the nation's need for improved communication in oncology. By utilizing a skills-based innovative program to educate these professionals, this proposal will equip and expand the workforce to meet a critical need in oncology.

PI_NAMEs: FERRELL, BETTY R (contact)

PROGRAM_OFFICER_NAME: ZAHIR, NASTARAN

PROJECT_TERMS: Association of Community Cancer Centers;cancer care;Cancer Center;Cancer Family;Cancer Patient;care coordination;career networking;Caring;Chaplain;Clinical Cancer Center;Clinical Oncology;cohort;Communication;Communities;Comprehensive Cancer Center;Diagnosis;Discipline;Discipline of Nursing;education research;Educational Curriculum;Educational workshop;Effectiveness;experience;Family;Family member;Goals;improved;innovation;Institution;Instruction;Interdisciplinary Communication;Knowledge;Leadership;Literature;Malignant Neoplasms;member;Mission;Modeling;National Cancer Institute;Nurses;Oncology;Oncology Group;online course;Organizational Change;Outcome;Participant;Patient Care;Patients;Peer Review;pilot test;Process Measure;Program Development;programs;psychologic;Psychological Stress;Psychosocial Assessment and Care;Publications;Reporting;Research;skill acquisition;skills;skills training;social;social stress;Social Work;Social Workers;Spirituality;Supportive care;System;Testing;Time;Trainers Training;Training;Training Programs

PROJECT_TITLE: Interdisciplinary Communication Training in Oncology

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHIATRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: We propose the use of a vibroacoustic device to enhance attention and interoception brain networks during breath-focused mindfulness meditation in dissociative traumatized people. Impairments in attention, particularly to body cues, interfere with treatment success in dissociative traumatized people. We will assess how this device, which vibrates in proportion to the breath, can target these networks and address neurobiological barriers to successful treatment engagement.

PI_NAMEs: FANI, NEGAR  (contact);SIEGLE, GREG J

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Acoustic Stimulation;Acoustics;Address;Affective;Anterior;Anxiety;Attention;attentional control;Awareness;barrier to care;Behavioral;Brain;Breathing;Cells;cingulate cortex;Clinical;clinically significant;Cognitive;Cues;Data;design;Development;Devices;Diagnostic;Disabling;Disease;Dissociation;Emotional;Emotions;Expenditure;experience;experimental study;Feedback;Functional Magnetic Resonance Imaging;Goals;Impairment;improved;Individual;Insula of Reil;Interoception;Intervention;Lead;Mechanoreceptors;Meditation;Mental Depression;Mind-Body Intervention;mindfulness;mindfulness meditation;neural;neural network;Neurobiology;neuromechanism;new technology;Parietal Lobe;Participant;Performance;Persons;Pilot Projects;Population;post intervention;Post-Traumatic Stress Disorders;Randomized;Recovery;recruit;Research;Resources;Respiration;response;Rest;Schizophrenia;Signal Transduction;Somatosensory Cortex;Sternum;Stimulus;Stress;success;sustained attention;Symptoms;Task Performances;Training;Trauma;Trauma patient;treatment response;Trust;vibration;Visit;wearable device

PROJECT_TITLE: Neural Mechanisms of Vibroacoustically Augmented Breath Focused Mindfulness for Dissociative Traumatized People


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Diabetes;Digestive Diseases;Genetics;Human Genome;Liver Disease;Obesity;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative A total of 18.2 million people in the U.S. currently live with type 2 diabetes and non-alcoholic fatty liver disease which, if not prevented or controlled, can lead to severe complications. Our work integrating etiologic trajectories of cardiometabolic disease into a genetic risk score aligns with the NIDDK's mission to fill gaps in our knowledge of the links between biological and environmental factors affecting health. Our genomics- informed and real-world data driven approach to drug repurposing may lead to the use of existing treatments for NAFLD with shortened drug development times.

PI_NAMEs: VUJKOVIC, MARIJANA  (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Acceleration;Affect;Alanine;Alanine Transaminase;Alleles;bench to bedside;biobank;Biological Factors;Blood Glucose;blood lipid;Body Weight;burden of illness;candidate identification;Cardiometabolic Disease;cardiometabolism;Cardiovascular system;Case Series;Cessation of life;Cirrhosis;Clinical;clinical data warehouse;clinical risk;Complex;cost effective;Data;data warehouse;Development;Diabetes Mellitus;diabetes risk;Disease;disease model;disorder prevention;drug candidate;drug development;drug discovery;drug efficacy;drug repurposing;Drug Targeting;Early Diagnosis;effective therapy;endophenotype;Environmental Risk Factor;Etiology;Evaluation;Exhibits;FDA approved;follow-up;Functional disorder;Gene Expression Profile;General Population;Genes;Genetic;genetic architecture;genetic association;Genetic Risk;Genome;genome wide association study;genomic locus;Genomics;Genotype;Goals;Health;Healthcare Systems;Hepatic;improved;Individual;insight;instrument;Intervention;IRS1 gene;Knowledge;Link;Liver;Liver diseases;Liver Fibrosis;liver transplantation;Malignant neoplasm of liver;Mediating;Mediation;Mediator;Medicine;Mendelian randomization;Methods;Mission;Modeling;multiple omics;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;non-alcoholic fatty liver disease;non-genomic;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Obesity;Obesity Epidemic;Onset of illness;Outcome;Pathway interactions;Patients;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacotherapy;Phenotype;PPARG gene;precision medicine;predictive modeling;Predisposition;Primary carcinoma of the liver cells;primary outcome;programs;Risk;Risk Factors;risk prediction;Signal Transduction;social factors;statistics;Strategic Planning;Sum;Symptoms;Therapeutic;trait;transcriptome;Transferase;Treatment Efficacy;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: A genomics-based strategy to precision phenotyping and drug repositioning in cardiometabolic diseases

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The objective of this research project is to elucidate a recently discovered receptor-mediated pathway, in which the fibrinolysis protease, tissue-type plasminogen activator (tPA), blocks the activity of Toll-like Receptors in innate immunity. We seek to understand the activity of tPA in complex inflammatory disorders and determine whether tPA may be engineered to develop novel anti-inflammatory drugs.

PI_NAMEs: GONIAS, STEVEN L. (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Activator Appliances;Active Sites;Agonist;Alteplase;Animals;antagonist;Anti-Inflammatory Agents;Arthritis;aspartate receptor;Binding;Biological Models;Bone Marrow;Breeding;Cell Physiology;cell type;Cells;Chemistry;Chronic;Clinical;Colon;Complex;cytokine;Data;dextran sulfate sodium induced colitis;Disease;disease model;Disease Progression;Dose;drug development;drug discovery;Elements;Engineering;experimental study;Family;Fibrinolysis;Funding;G-Protein-Coupled Receptors;Gene Deletion;Generations;Genetic Engineering;Goals;Grant;gut inflammation;Hemostatic function;Immunity;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;K/BxN model;Laboratories;LDL-Receptor Related Protein 1;Lipopolysaccharides;Macrophage;Macrophage Colony-Stimulating Factor;Mediating;mimetics;Modeling;monocyte;mouse model;Mus;N-Methyl-D-Aspartate Receptors;Natural Immunity;neutrophil;NMDA receptor A1;novel;Pathogenesis;Pathology;Pathway interactions;Pattern recognition receptor;Peptide Hydrolases;Peritoneal Macrophages;Pharmaceutical Preparations;Phase;Plasmin;Plasminogen;Plasminogen Activator;Plasminogen Activator Inhibitor 1;Process;Progress Reports;promoter;Proteins;Publishing;receptor;receptor function;Recombinants;Regulation;Regulatory Pathway;Research Project Grants;Resistance;response;Serine;Serine Protease;Serpins;Serum;Signal Pathway;Signal Transduction;src-Family Kinases;Structure;Symptoms;System;Testing;Therapeutic;therapeutic candidate;tissue injury;Tissues;TLR2 gene;TLR4 gene;TLR7 gene;Toll-like receptors;Toxic effect;Transactivation;transcriptomic profiling;Wild Type Mouse;Work

PROJECT_TITLE: Regulation of Inflammation by the Fibrinolytic System

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Multiple Sclerosis;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: CALGARY

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF CALGARY

ORG_STATE: AB

ORG_ZIPCODE: T2N 1N4

PHR: Project Narrative Multiple sclerosis is a major cause of neurological disability in young adults in the western world. This project will fundamentally change our understanding of this disease by refocusing attention from the conventional autoimmune view, to one based on toxic protein misfolding promoting degeneration of axons, neurons and myelin. These insights will open completely new directions for therapeutic design that will complement current anti-inflammatory therapies, and more importantly, guide development of drugs for progressive MS where most irreversible disability occurs, and for which we currently have limited therapeutic options.

PI_NAMEs: STYS, PETER K (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: adaptive immunity;Anti-Inflammatory Agents;astrogliosis;Attention;Autoimmune;Autoimmunity;axon injury;axonal degeneration;Behavior;Behavioral;Biochemical;Brain;Charge;Chronic;CNS Demyelinating Autoimmune Diseases;Complement;Deposition;design;disability;Disease;drug development;Etiology;experimental study;Genes;Histology;Human;Human Pathology;Immunoprecipitation;Inflammatory;Injections;insight;intraperitoneal;locomotor deficit;Lymphocyte;Magnetic Resonance Imaging;Maintenance;Methods;misfolded protein;Monitor;Multiple Sclerosis;Mus;Myelin;Myelin Basic Proteins;Myelin Proteins;myelinopathy;Neurological disability;Neurons;Oligodendroglia;Organ;Pathogenesis;Pathologic;Pathology;Phenotype;Physiological;Play;Post-Translational Protein Processing;Predisposition;prion-like;Prions;protein aggregation;protein misfolding;protein protein interaction;Proteins;PrP;Reaction;response;Risk;Route;Secondary to;Sensory;Source;Specificity;Spinal Cord Diseases;Spleen;Testing;Therapeutic;Toxic effect;Transgenic Mice;transmission process;Western World;white matter;young adult

PROJECT_TITLE: Multiple sclerosis as a cytodegenerative proteopathy

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Arrhythmias increase the risk of heart attack, cardiac arrest and stroke while atrial fibrillation alone is expected to affect 12 million U.S. patients by 2050. The current treatment procedures are lengthy, costly and are plagued by low to moderate success rates. Our objective is to assess the clinical role of our ultrasound-based imaging methodology that can better identify arrhythmic origins and focally inform on the success of subsequent arrhythmia treatment so as to substantially improve the current success rates and abbreviate procedure duration and/or number of procedures.

PI_NAMEs: KONOFAGOU, ELISA E. (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Abbreviations;Ablation;Address;Affect;Aftercare;Aging;Area;Arrhythmia;Atrial Fibrillation;Atrial Flutter;Automation;Back;Biological Markers;Biometry;Blood;blood pump;Cardiac;Chest;Clinical;clinically relevant;Compensation;computerized data processing;cost;Cost efficiency;Diagnostic Imaging;Disease;Distress;Echocardiography;Electric Countershock;electrical property;Electrocardiogram;Event;Failure;Feedback;Frequencies;Funding;Generations;Healthcare;Heart;Heart Arrest;Heart Atrium;heart rhythm;Hour;Image;Imaging Techniques;improved;Individual;Intervention;Journals;Lead;Length;Life;Machine Learning;Maps;Measures;mechanical drive;mechanical properties;Mechanics;medical specialties;Methodology;multidisciplinary;Myocardial Infarction;noninvasive diagnosis;novel imaging technology;Pain;Pathology;Patients;Peer Review;Pharmacological Treatment;predicting response;Prevalence;Procedures;Progress Reports;Prospective Studies;Publications;Pump;Radiofrequency Interstitial Ablation;response;Risk;Role;Sinus;Source;Stroke;success;sudden cardiac death;Therapeutic;Time;treatment response;ultrasound;United States;Ventricular Arrhythmia;Ventricular Fibrillation;Ventricular Tachycardia

PROJECT_TITLE: Arrhythmia mapping using electromechanical wave imaging

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: MEMPHIS

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Systemic amyloidosis is a rare but devastating pathology characterized by the extracellular deposition of protein fibrils in major organs and tissues, notably the heart and kidneys. Despite decades of research into the pathogenesis of these disorders and improvements in patient survival rates, they remain invariably fatal due to the inability to effectively remove tissue amyloid. The goal of this proposal is to develop an amyloid-binding reagent capable of harnessing the cells of the immune system to effect amyloid clearance, and that can also be used to image amyloid deposits, yielding new options for clinical trial design, patient stratification, and improved patient outcomes.

PI_NAMEs: WALL, JONATHAN S (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Affinity;Amyloid;Amyloid Fibrils;amyloid imaging;Amyloidosis;Animals;Antibodies;Binding;Biodistribution;Biological Assay;Biological Factors;Cardiac;Cells;Cessation of life;Chinese Hamster Ovary Cell;Clinic;Clinical;clinical development;clinical implementation;clinical translation;Clinical Trials;Clinical Trials Design;Companions;Complement;Deposition;Development;Diagnosis;Disease;Disease remission;Drug Design;Drug Kinetics;efficacy evaluation;Evaluation;Excision;Exhibits;extracellular;Family;Fc domain;Fc Immunoglobulins;Fc Receptor;fluorophore;Functional disorder;Goals;Half-Life;Heart;Heterogeneity;Histologic;Human;IgG1;Image;imaging agent;imaging study;Immune system;Immunoglobulin Fragments;Immunologics;Immunotherapeutic agent;Immunotherapy;Implant;improved;In Vitro;in vivo;Incidence;Iodine;Kidney;Label;lead candidate;Macrophage;Mass Spectrum Analysis;Measurement;Mediating;Methods;microautoradiography;molecular imaging;Monoclonal Antibodies;Monoclonal Antibody Therapy;Morbidity - disease rate;mouse model;Mus;next generation;novel;optical imaging;Organ;Outcome;Pathogenesis;Pathology;patient screening;Patient Selection;patient stratification;Patient-Focused Outcomes;Patients;Peptides;Performance;Peripheral Nerves;PET/CT scan;Phagocytes;Phagocytosis;Phagocytosis Induction;Phagolysosome;Phase;Plasma;Population;prevent;Production;Program Development;programs;Protein Precursors;Proteins;Radiolabeled;Reagent;recruit;Research;single photon emission computed tomography;Specificity;success;Survival Rate;synthetic peptide;theranostics;Therapeutic;therapy design;Time;Tissues;tool;Translations;Treatment Efficacy;trial design;uptake;Variant;whole body imaging;X-Ray Computed Tomography

PROJECT_TITLE: Development of a Theranostic Immunotherapy for Systemic Amyloidosis

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND STATE UNIVERSITY

ORG_STATE: OR

PHR: The proposed scientific training program seeks to address an urgent need: diversifying the biomedical workforce in the United States. U-RISE at PSU will build on our previous experience recruiting, retaining, and training underrepresented students to enter careers in biomedical research. To achieve these goals, we will rely on hands-on learning and research experiences and an integrated and supportive community of mentors, faculty, and peers at Portland State University, which is a diverse urban institution well suited and prepared to conduct this training program.

PI_NAMEs: KELLER, THOMAS E (contact);MORRIS, CYNTHIA D

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Active Learning;Address;Admission activity;Biomedical Research;career;career development;cohort;Collaborations;Communities;design;Education;education planning;Educational Curriculum;Educational workshop;Ensure;evidence base;experience;Faculty;Fostering;Immersion;inquiry-based learning;Institutionalization;interest;intervention program;Investigation;learning community;learning engagement;Mentors;Outcome;Pathway interactions;peer;peer coaching;Phase;Phase Transition;Preparation;programs;Publishing;recruit;Reporting;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Research Training;responsible research conduct;scaffold;Science;Scientist;Self Efficacy;social;student mentoring;Students;summer research;supportive environment;symposium;Thinking;Time;Training;Training Programs;undergraduate student;Underrepresented Populations;Universities

PROJECT_TITLE: U-RISE at Portland State University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Aging;Brain Disorders;Estrogen;Natural Products;Neurodegenerative;Neurosciences;Parkinson's Disease;Women's Health Research

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Parkinson’s disease (PD) incidence rates predict a worldwide pandemic that will affect over 12 million people and exert an annual economic burden of $14 billion by the year 2040. There is therefore an urgent need to discover neuroprotective drugs that will prevent the progression of PD rather than treating symptoms. We will determine mechanisms by which a nicotinic compound, cytisine and estrogen synergistically exert neuroprotection, which will enable the development of effective and clinically translatable neuroprotective drugs for PD in men and women.

PI_NAMEs: SRINIVASAN, RAHUL  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: acetylcholine receptor agonist;Address;Affect;Age of Onset;Animal Model;Apomorphine;Apoptotic;arm;ATF6 gene;Attenuated;Behavior;Behavioral;Binding;Cell Death;Cell membrane;Cell Nucleus;Chronic;clinical translation;Clinical Trials;Complex;Corpus striatum structure;cytisine;Cytoplasm;Data;Development;Dopaminergic Cell;dopaminergic neuron;Dose;Drug Combinations;Drug Kinetics;Economic Burden;Endoplasmic Reticulum;endoplasmic reticulum stress;Estradiol;Estrogen Receptors;Estrogens;experimental study;Exposure to;Female;follow-up;Gait;Genetic Transcription;Goals;Gonadal Steroid Hormones;Heat shock proteins;Human;Image;in vivo;Incidence;Injections;Lesion;Ligands;male;Mediating;men;Midbrain structure;Modeling;Molecular;Molecular Chaperones;motor symptom;mouse model;Mus;Neurodegenerative Disorders;neuron loss;Neurons;neuroprotection;Neuroprotective Agents;nicotine use;Nicotinic Receptors;novel;Outcome;Ovariectomy;Oxidopamine;pandemic disease;Parkinson Disease;Patients;Persons;Pharmaceutical Preparations;Phenotype;pre-clinical;preclinical study;preservation;prevent;Process;protein activation;Protein Export Pathway;Proteins;receptor;Role;Rotation;Sex Differences;Signal Pathway;Signal Transduction;Site;smoking cessation;Structure;success;symptom treatment;Testing;Toxic effect;Toxin;transcription factor;Transgenic Mice;Transgenic Organisms;translational barrier;Up-Regulation;Woman;women's treatment;Work;XBP1 gene

PROJECT_TITLE: Identification of mechanisms by which cytisine and estrogen inhibit ER stress and exert neuroprotection in Parkinson's disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Lung;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE:  Oxygen therapy (hyperoxia) is the most frequently administered intervention in hospitalized patients. Although often life-saving, hyperoxia can also initiate lung injury in otherwise healthy individuals or further accentuate already ongoing lung injury. Since currently no therapies exist to counteract hyperoxia-induced lung injury, this proposal explores lung epithelial and endothelial TREK-1 potassium channels as a potentially new target to counteract hyperoxia-induced lung injury.

PI_NAMEs: SCHWINGSHACKL, ANDREAS  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: acute hypoxemic respiratory failure;Acute Lung Injury;Affect;AGTR2 gene;Alveolar;alveolar epithelium;Animal Model;Apoptosis;Award;Awareness;Biochemical Markers;Biological Assay;biophysical properties;Budgets;Cell membrane;Cell Separation;cell type;Cells;Clinical;Clinical Research;Co-Immunoprecipitations;Complex;Data;Death Rate;Development;Down-Regulation;Drug Design;Endothelial Cells;Endothelium;Environment;Epithelial Cells;Epithelium;experimental study;Exposure to;Fluorometry;Functional disorder;Genetic Enhancement;Healthcare;Histologic;Hospitalization;Human;Hyperoxia;hyperoxia induced lung injury;improved;In Vitro;in vivo Model;Individual;Inflammation;Inflammation Mediators;Inflammatory Response;innovation;Intervention;Knockout Mice;Label;Length;Life;Lung;lung injury;Mass Spectrum Analysis;Measures;Mediating;Membrane Potentials;Mentored Clinical Scientist Development Program;Molecular Target;Morbidity - disease rate;Morphology;mouse model;Mus;novel;novel strategies;overexpression;Oxygen;Oxygen Therapy Care;oxygen toxicity;patch clamp;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Physiological;Potassium Channel;potassium channel protein TREK-1;prevent;Process;protective effect;Pulmonary Inflammation;Role;Signal Pathway;Signal Transduction;Structure;Supplementation;targeted treatment;Testing;Therapeutic;Translating;voltage

PROJECT_TITLE: Trek-1 Potassium Channels Protect from Hyperoxia-induced Acute Lung Injury

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Precision Medicine;Rare Diseases

PHR: Metabolic Biomarkers of Response of Mantle Cell Lymphoma to Bruton Tyrosine Kinase Inhibition Project Narrative We are developing a novel method for noninvasive detection of response of human mantle cell lymphoma (MCL) to a new class of drugs, inhibitors of Bruton's Tyrosine Kinase, two of which, ibrutinib (IBR) and acalabrutinib, have recently been approved by the FDA for MCL, chronic lymphocytic leukemia (CLL), marginal zone lymphoma and also evaluated for other types of lymphoma. We are developing magnetic resonance imaging and spectroscopy (MRI/MRS) methods that detect changes in tumor metabolism resulting from BTK inhibition. Our preclinical studies will pave the way for applying MRI/MRS-based tumor imaging to patients with a broad spectrum of cancers treated with diverse kinase inhibitors.

PI_NAMEs: NATH, KAVINDRA  (contact);WASIK, MARIUSZ A.

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: Address;Adjuvant Therapy;Aerobic;Aftercare;Agammaglobulinaemia tyrosine kinase;Alanine;Biochemical Pathway;Biological Markers;Biological Models;Biopsy Specimen;Bioreactors;cancer cell;cancer imaging;Cancer Patient;cancer therapy;cell growth;Cell Line;Cells;Chemicals;Choline;Chronic Lymphocytic Leukemia;Citric Acid Cycle;clinical application;Critical Pathways;Cytostatics;cytotoxic;Data;Data Analyses;Detection;detection method;Drug resistance;Early Diagnosis;Enzymes;FDA approved;fluorodeoxyglucose positron emission tomography;Foundations;Future;Gene Expression Profiling;Generations;Genes;genome-wide;Genomics;glucose monitor;glucose uptake;Glutaminase;Glycolysis;Glycolysis Inhibition;Goals;Growth;hexokinase;Human;Hypoxia;Image;imaging biomarker;Imaging Techniques;immunosuppressed;In Vitro;in vivo;in vivo Model;in vivo monitoring;indexing;Infiltration;inhibitor;inhibitor therapy;innovation;Institution;instrument;kinase inhibitor;Lactic acid;Lymphoma;Lymphoma cell;Magnetic Resonance Imaging;Malignant Neoplasms;Mantle Cell Lymphoma;Measures;Messenger RNA;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Modeling;Monitor;Mus;neoplastic cell;NMR Spectroscopy;Non-Invasive Detection;non-invasive imaging;novel;novel drug class;novel strategies;Nutritional Requirements;Pathway Analysis;Pathway interactions;Patients;Pentosephosphate Pathway;Perfusion;Pharmaceutical Preparations;Phospholipid Metabolism;Phosphoproteins;phosphoproteomics;Phosphorylation;Physiologic pulse;potential biomarker;preclinical study;Process;Proteins;Proteomics;quantum;Resistance;response;response biomarker;Signal Pathway;Signal Transduction;Site;Spectrum Analysis;Techniques;Testing;Therapeutic Agents;therapy resistant;tissue culture;Tissues;transcriptome sequencing;treatment response;tumor;tumor growth;tumor metabolism;Tumor Volume;tumor xenograft;Tyrosine Kinase Inhibitor;X-Ray Computed Tomography;Xenograft procedure


ORG_CITY: DAVIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARATIVE In every heartbeat, cardiac muscle contracts against a mechanical load to pump blood into circulation to meet the body’s demands. Pathological overload leads to cardiac dysfunction and heart diseases. The proposed research will develop innovative technology to investigate the cellular and molecular mechanisms underlying load-induced cardiac arrhythmias and heart failure. The results will provide new therapeutic strategies for treating high blood pressure associated heart diseases such as arrhythmias and heart failure.

PI_NAMEs: CHEN-IZU, YE  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Affect;Arrhythmia;Biology;blood pump;Cardiac;Cardiac Myocytes;Cardiac Output;Cells;Chemistry;Circulation;Contracts;Coupling;design;Disease;dynamic system;experimental study;Feedback;Gel;Goals;Health;Heart;Heart Diseases;Heart failure;heart function;Hypertension;innovation;innovative technologies;interdisciplinary approach;Knowledge;mechanical load;Mechanical Stress;mechanotransduction;Methods;Modeling;Molecular;Molecular Target;Myocardial dysfunction;Myocardium;new technology;novel therapeutic intervention;novel therapeutics;Outcome;Outcomes Research;Pathologic;Pathway interactions;Physics;Pump;Recording of previous events;Research;response;Signal Transduction;STEM research;Technology;Therapeutic;Work

PROJECT_TITLE: Mechanical Load Effects on Cardiac Function and Heart Diseases


ORG_CITY: CINCINNATI

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative Regulation of residue-specific protein ADP-ribosylations by ADP-ribosyl-acceptor hydrolases (ARHs) is important for cellular responses to DNA damage and the uncontrolled accumulation of ADP-ribosylations causes genomic instability, often leading to diseases. We aim to develop new quantitative tools that selectively monitor the reversal of different residue-specific ADP-ribosylations by ARHs and to elucidate the mechanisms of substrate selectivity and cleavage of ARHs. Our studies will overcome the existing technical hurdles in selective and quantitative measurement of site-specific ADP-ribosylations and will provide in-depth understanding of the roles of each enzymatic activity of ARHs in maintaining genomic integrity.

PI_NAMEs: KIM, IN-KWON  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: ADP ribosylation;Arginine;Bacterial Toxins;base;Binding;Biological Assay;Biological Process;Catalysis;Cell Death;Cells;Cholera Toxin;Complex;cytotoxicity;Data;Diphtheria Toxin;Disease;DNA Damage;Engineering;Enzymes;Family;Fluorescence;Fluorescence Resonance Energy Transfer;Gene Expression;genome integrity;Genomic Instability;genotoxicity;Homeostasis;Hydrolase;Hydrolysis;In Vitro;Injury;Kinetics;Life;Ligand Binding;Link;Malignant Neoplasms;Measurement;Measures;Metal Binding Site;metalloenzyme;Metals;Methods;Modification;Molecular Conformation;Monitor;mutant;Natural Immunity;Nature;Nerve Degeneration;Normal Range;novel;Pathologic;Peptides;Physiology;Play;Post-Translational Protein Processing;Process;Proteins;Radioactive;Regulation;response;Role;Series;Serine;Signal Transduction;Site;Specificity;Structure;Surgical incisions;Testing;Time;tool;Transferase

PROJECT_TITLE: Reversal of residue-specific ADP-ribosylations by ADP-ribosyl-acceptor hydrolases

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Mental Health;Prevention;Rural Health;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative Over the past decade, mortality from coronary heart disease has increased in rural women, in contrast to other sociodemographic groups for whom the rates have been slowly improving. Because traditional risk factors such as hypertension and hyperlipidemia do not explain this growing disparity, this research project examines non-traditional psychosocial, behavioral, immune, endocrine, and physiological mechanisms that were not comprehensively examined before, in a cohort of 4,600 rural Americans in the Appalachia and Mississippi Delta region. This research will be critical in our understanding of heart disease pathogenesis not just in rural women, but all women, as well as men, and will shed light on potential public health and clinical interventions that may improve outcomes.

PI_NAMEs: SHAH, AMIT JASVANT (contact);VACCARINO, VIOLA

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Age;aged;aging population;Ankle;Appalachian Region;Behavior;Behavioral;biological adaptation to stress;Biological Factors;Biological Markers;biological sex;biopsychosocial;Blood Vessels;Brain;Cardiac;cardiometabolic risk;Cardiotoxicity;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Cellular Phone;Chest;circadian;Clinical;cohort;Cohort Studies;coronary calcium scoring;Coronary heart disease;Data;Disparity;Domestic Violence;Ecological momentary assessment;Economics;Electrocardiogram;Endocrine;Equity;Evaluation;Event;experience;Exposure to;Face;Family Violence;Financial Hardship;Gender;gender difference;Gender Role;Health Services Accessibility;Heart;heart disease risk;Heart Diseases;high risk;Hormonal;Hyperlipidemia;Hypertension;Immune;improved;improved outcome;Incidence;indexing;Individual;Inflammation;Inflammatory;Inflammatory Response Pathway;insight;Interleukin-6;Intervention;Investigation;Life;male;Measures;men;Mental Depression;Mental Health;Metabolic;middle age;Mississippi;Monitor;Moods;mortality;Movement;mullerian-inhibiting hormone;multimodality;Neighborhoods;Neurosecretory Systems;novel;Ovarian;Ovarian aging;Pathogenesis;Pathway interactions;Patient Self-Report;Pattern;perceived stress;Persons;Phenotype;Physical activity;Physiologic Monitoring;Physiologic pulse;Physiological;Play;Policies;Population;Post-Traumatic Stress Disorders;premature;Prevention;primary outcome;Psychological Stress;psychosocial;Psychosocial Assessment and Care;Psychosocial Stress;Public Health;Race;reproductive;Reproductive Physiology;reproductive senescence;Research;Research Project Grants;Resources;Respiration;Risk;Risk Factors;risk prediction;Rural;rural Americans;rural area;Rural Community;rural counties;Safety;Sampling;secondary outcome;sensor;Sentinel;sex;Sex Differences;Sleep;social;social adversity;social cohesion;sociodemographic group;Stereotyping;Stress;Stressful Event;Substance abuse problem;Testing;tool;Trauma;trend;United States;wearable device;Woman;wristband;young woman

PROJECT_TITLE: Investigation of Sex and Gender Differences in Cardiovascular Risk in Rural Communities


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Genetics;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Endocannabinoids are early signaling molecules which profoundly influence brain development. The innate immune system is also emerging as an important influencer of brain maturation and studies here explore the interaction between the two. The use of cannabis during pregnancy is increasing in response to perceptions of safety following decriminalization, medicalization and legalization yet the impact on the developing fetal brain remains unknown. This research seeks to begin to fill that gap.

PI_NAMEs: MCCARTHY, MARGARET M. (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: 2-arachidonylglycerol;Adolescence;Adolescent;Adult;Age;Amygdaloid structure;Androgen Receptor;androgen sensitive;Androgens;astrocyte progenitor;Astrocytes;axon guidance;Behavior;Birth;Brain;brain cell;Brain region;Breast Feeding;Cell Proliferation;Cell Survival;cell type;Cells;Chemotactic Factors;CNR1 gene;CNR2 gene;Complement;Complement 3b;complement system;Complex;Consumption;critical period;density;Dependovirus;Development;Endocannabinoids;endogenous cannabinoid system;Enzymes;Epigenetic Process;excitatory neuron;Exposure to;Face;Family member;Farm;Female;fetal;Foundations;Future;Gene Targeting;Genes;Goals;Human;Immune;Immune system;In Situ Hybridization;inhibitory neuron;Innate Immune System;Internet;Knowledge;Left;Legal;male;Marijuana;marijuana use in pregnancy;Measures;Medial;Mediating;Medical;Membrane Lipids;Messenger RNA;Microglia;Natural Immunity;Neonatal;neural circuit;neurogenesis;Neuroimmune system;Neurons;Newborn Infant;Organ;Participant;Perception;perinatal brain;Phagocytes;Phagocytosis;Phenotype;Play;Population;Predisposition;Pregnancy;Process;Production;Proteins;Rattus;Research;response;Safety;sex;Sex Differences;Signal Transduction;Signaling Molecule;single nucleus RNA-sequencing;Small Interfering RNA;social;Social Behavior;Source;Specificity;stem cells;Stimulus;Surface;System;Techniques;THC exposure;Time;tool;transcriptome;transcriptomics;Vacuum

PROJECT_TITLE: Endocannabinoids regulate microglia in developing brain

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative  The proposed studies will determine the role, identity and origin of tumor supporting osteolineage Osx+ cells in breast cancer progression.

PI_NAMEs: FACCIO, ROBERTA  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: 4T1;Adoptive Transfer;Adult;Affect;Antigen Presentation;Biological Assay;bone;Bone Marrow;Bone Marrow Transplantation;breast cancer progression;Breast Carcinoma;cancer cell;cancer therapy;Cell Separation;Cells;ChIP-seq;Circulation;cytokine;Deposition;design;Development;Disease;Distant;Ectopic Expression;Embryo;Environment;Extracellular Matrix;Fibroblasts;fighting;Generations;Genes;Genetic;Growth;Growth Factor;Heterogeneity;Immune;immunoregulation;Infiltration;Injections;Interruption;Investigation;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Neoplasms;mature animal;Mesenchymal;mesenchymal stromal cell;Metastatic breast cancer;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;Normal Cell;novel;novel marker;novel therapeutic intervention;Osteoblasts;osteogenic;Patients;polyoma middle tumor antigen;Population;postnatal;premalignant;Production;progenitor;Prognosis;promoter;recruit;Reporter Genes;response;Role;single-cell RNA sequencing;Site;skeletal stem cell;Skeleton;Soil;Source;Specificity;Stromal Cells;Surface;transcription factor;Transplantation;tumor;tumor growth;Tumor Markers;tumor microenvironment;tumor progression;tumorigenic

PROJECT_TITLE: Role of Osterix+ Osteolineage Cells in Primary and Metastatic Breast Cancer

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project narrative The junctional epithelium (JE) serves as the first line of defense against periodontal diseases, and its barrier functions are maintained by a stem cell niche. Here, we will identify and characterize the roles of Wnt/β-catenin signaling in maintaining the stem cell pool during JE homeostasis and during injury repair. We also test a biochemical approach for re-establishing JE barrier functions after damage and disease that, if successful, opens up new avenues for periodontal disease treatment and prevention.

PI_NAMEs: HELMS, JILL A (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Address;Adenoviruses;alveolar bone;Anatomy;beta catenin;Biochemical;Bone Morphogenetic Proteins;Bromodeoxyuridine;Cell Cycle;Cell Cycle Kinetics;Cell Differentiation process;Cells;Clinical;Connective Tissue;Data;Dental Cementum;Differentiation Antigens;Disease;Embryo;Epithelial Attachment;Epithelial Cell Junction;Epithelial Cell Proliferation;Epithelial Cells;epithelial stem cell;Epithelium;epithelium regeneration;Excision;experimental study;Exposure to;Flow Cytometry;Fluorescent in Situ Hybridization;Formulation;Gene Expression Profile;Gene Expression Profiling;Genes;Gingiva;Gingivectomy;Goals;Harvest;Health;Hemidesmosomes;Heterogeneity;Histology;Homeostasis;Human;Immunoglobulin G;Immunohistochemistry;Infiltration;Inflammatory;inhibitor;Injury;injury and repair;innovation;insight;Jaw;Knowledge;Label;Libraries;Ligature;lipid nanoparticle;Maintenance;Mediating;Modeling;Molecular;Mus;Natural regeneration;new therapeutic target;notch protein;novel therapeutic intervention;Operative Surgical Procedures;Oral;Oral cavity;Pathway interactions;Periodontal Diseases;Periodontal Ligament;Periodontitis;Placebos;Population;preservation;Prevention;Prevention strategy;Proliferating;protein distribution;Recombinants;Regenerative capacity;repair model;Reporter;Research Personnel;restoration;RNA Probes;Role;self-renewal;Series;Signal Transduction;Site;Skeleton;soft tissue;Sorting;Source;Stains;stem cell biomarkers;stem cell niche;stem cell self renewal;stem cells;Tamoxifen;targeted treatment;Testing;Therapeutic;therapeutic protein;Tissues;Tooth structure;tooth surface;Tracer;Wnt proteins;WNT Signaling Pathway;Wnt-3A protein;Work;wound healing

PROJECT_TITLE: Molecular mechanisms mediating the soft tissue attachment to teeth

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative A molecular chaperone that regulates the abnormal accumulation of the microtubule associated protein tau in the brain has now been linked to the neuropsychiatric symptoms in Alzheimer’s disease (AD). This project will determine if targeting this protein can be protective and explore the molecular pathways that may underly the link to depression in AD.

PI_NAMEs: BLAIR, LAURA J (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Ablation;Affect;Affective Symptoms;Aging;aging population;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Attenuated;Behavior assessment;Behavioral;Biology;Brain;Cognitive;Cognitive deficits;Data;Disease Progression;Electrophysiology (science);excitatory neuron;FK506 binding protein 5;Functional disorder;genetic variant;Goals;Health;hormonal signals;Immune response;Impaired cognition;Impairment;In Vitro;in vivo;inhibitor;insight;knock-down;Knockout Mice;Knowledge;Link;MAPT gene;Mediating;Mental Depression;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Molecular Chaperones;Mood Disorders;mouse development;mouse model;Mus;neuron loss;Neurons;neuropathology;neuropsychiatric symptom;neurotoxic;neurotoxicity;Obesity;Outcome;Pathogenesis;Pathologic;Pathway interactions;Patients;polyglutamine;Proteins;Proteomics;Research;resilience;Respiration;Risk;risk variant;Role;Short-Term Memory;Single Nucleotide Polymorphism;steroid hormone;Stress;Structure;Synapses;Synaptic plasticity;Synaptosomes;Tacrolimus Binding Proteins;tau aggregation;tau mutation;tau Proteins;tau-1;Tauopathies;Testing;Toxic effect;transcriptomics;Transgenic Mice;Variant;Work

PROJECT_TITLE: The hsp90 Cochaperone FKBP51 Regulates tau Structure and Function

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Clinical Research;Hematology;Rare Diseases;Sickle Cell Disease

ORG_CITY: SEATTLE

ORG_NAME: BLOODWORKS

PHR: Work proposed here will continue work to elucidate the roles of VWF and oxidative stress in sickle cell disease (SCD) and von Willebrand disease (VWD). In SCD, we will explore the nature of excessive VWF activity in the disease, and investigate the mechanism for why patient blood contains very dense red blood cells. In SCD, we will investigate the reasons that members of the same family carrying the same mutation display widely different bleeding manifestations.

PI_NAMEs: LOPEZ, JOSE ARON (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Acetylcysteine;ADAMTS;Affect;Amino Acids;Animal Model;Area;Award;Blood;Blood Platelets;Defect;Disease;Erythrocytes;expectation;Family;fascinate;flexibility;Food;Funding Mechanisms;Goals;Grant;Hematological Disease;Hemorrhage;Hemostatic Agents;human disease;improved;Lesion;Measures;member;Metalloproteases;Molecular;monomer;mutant;Mutation;National Heart, Lung, and Blood Institute;Nature;Oxidative Stress;Patients;Pharmaceutical Preparations;Phenotype;Plasma;Plasma Proteins;Proteolysis;Regulation;Research Personnel;Role;Sickle Cell Anemia;Spectrin;Testing;tool;translational study;von Willebrand Disease;von Willebrand Factor;Work

PROJECT_TITLE: Molecular and Translational Studies in Hematologic Disorders


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project Narrative COVID-19 has disproportionately impacted Latinos and other racial/ethnic minority groups. Effective intervention strategies are needed to stop household- and subsequent community- spread of COVID-19 among Latinos. This study will test the immediate, mid-term and long-term efficacy of a tailored intervention to prevent household and community spread of COVID-19 among Latinos.

PI_NAMEs: CRESPO, NOE CUAUHTEMOC (contact);RAMERS, CHRISTIAN B

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Adherence;Adult;Behavior;behavior change;Behavior Therapy;Behavioral;behavioral health;California;Cellular Phone;Cessation of life;Chronic;Chronic Disease;Clinical;clinical care;Collaborations;Communicable Diseases;Communities;community academic partnership;Community Health Aides;community partners;community transmission;comparison group;Counseling;COVID-19;COVID-19 complications;COVID-19 diagnosis;COVID-19 mortality;COVID-19 pandemic;COVID-19 prevention;COVID-19 risk;Data;Death Rate;Diagnosis;disability;Disparity;distrust;economic impact;Economics;Education;effective intervention;efficacy testing;Emotional;emotional distress;ethnic minority population;evidence base;experience;Family health status;Federally Qualified Health Center;flexibility;follow-up;Future;Government;group intervention;Health;health care service;health communication;high risk population;Hispanic-serving Institution;Home;Home environment;Household;Housing;indexing;Infrastructure;innovation;Intervention;Latin America;Latino;Latino Population;Low income;member;Mental Health;Misinformation;model design;Modeling;Morbidity - disease rate;motivational enhancement therapy;novel;Occupations;Outcome;pandemic disease;Participant;Patients;physical conditioning;Population;Positioning Attribute;Poverty;prevent;Preventive;promoter;Psyche structure;Public Health;public health emergency;racial minority population;Randomized;Recommendation;recruit;Research;Resources;Risk;Risk Factors;Risk Reduction;SARS-CoV-2 infection;Services;severe COVID-19;social;Social Distance;standard of care;Sustainable Development;Techniques;Technology;Testing;theories;Time;Underserved Population;United States;vaccine acceptance;virtual

PROJECT_TITLE: Tailored Behavioral Intervention to Prevent Household and Community Spread of COVID-19 among Latinos

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(56)R]


ORG_CITY: DALLAS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Public Health relevance/Narrative Decoding the features of signaling unique to the primary cilium in directing downstream cellular pathways is essential for understanding the pathogenesis of diseases caused by ciliary dysfunction. This project addresses key processes in ciliary signaling that include compartmentalization and counterregulatory signaling using mouse models in multiple developmental contexts. Studying ciliary signaling will provide insights into how cellular pathways regulate development and will further our understanding of disease pathologies in humans.

PI_NAMEs: MUKHOPADHYAY, SAIKAT  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;Adenylate Cyclase;Affect;appendage;cell type;cellular transduction;Centrosome;Cilia;ciliopathy;Complex;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyst;Development;Disease;Embryology;Erinaceidae;extracellular;Functional disorder;Homeostasis;Human;Human Genetics;innovation;insight;Kidney;Microtubules;Morphogenesis;morphogens;Morphology;mouse model;Nephrology;Neural tube;Neural Tube Closure;neuropathology;Outcome;Pathogenesis;Pathology;Pathway interactions;Pattern;Phenotype;preservation;prevent;Process;Proliferating;Property;Proteomics;public health relevance;Regulation;Repression;Research;response;Role;Signal Transduction;Signaling Molecule;smoothened signaling pathway;Testing;Tissues;trafficking;translational potential;Tubular formation;Vertebrates;Work

PROJECT_TITLE: Signaling at the primary cilium in development and disease

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE First uncovered in the context of the fatal transmissible spongiform encephalopathies, prions are infectious, self-propagating protein aggregates that also exist in yeast and other fungi, where they act as heritable, protein-based genetic elements that can enhance survival under specific stressful conditions. The recent discovery of bacterial prions provides the foundation for the proposed studies, which will explore the scope and significance of prion-like phenomena in bacteria. The human health implications of bacterial prions could be far-reaching, from potential roles in antibiotic tolerance and immune evasion in the context of infection to potential effects on the human proteome via cross-Kingdom templating interactions within the human microbiota.

PI_NAMEs: HOCHSCHILD, ANN  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TITLE: Prions in the bacterial domain of life

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Research;Youth Violence

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Exposure to interpersonal trauma is unfortunately common and substantially increases the risk of alcohol use disorder (AUD) in young adulthood; though not all youth exposed to trauma develop AUD suggesting there are certain individuals at greatest risk for alcohol problems following trauma exposure. Identifying these high-risk individuals, and the neurobiological mechanisms contributing to their risk, can pinpoint early intervention targets and aid in AUD prevention. The current study will therefore combine measures of brain function, psychophysiology, and behavior, with a prospective design of progression to escalated alcohol use, to test a novel neurobiological risk phenotype for alcohol problems within trauma-exposed youth.

PI_NAMEs: GORKA, STEPHANIE  (contact);PHAN, K. LUAN

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: 19 year old;Address;Alcohol abuse;Alcohol consumption;Alcohol Phenotype;alcohol risk;alcohol use disorder;Anterior;Anxiety;Area;Behavior;Behavioral;behavioral response;binge drinking;Brain;brain behavior;cingulate cortex;Cognitive;cohort;coping;Data;data integration;Data Reporting;design;Detection;Development;disorder prevention;Dorsal;drinking;drinking behavior;Early Intervention;Event;experience;Exposure to;follow-up;Frequencies;Future;Goals;Heavy Drinking;high risk;high risk population;Individual;Individual Differences;innovation;Insula of Reil;interpersonal trauma;Intervention;Knowledge;Literature;longitudinal design;Measures;Mediating;Modeling;Motivation;multimodal data;multimodality;network dysfunction;neurobiological mechanism;Neurobiology;Neurophysiology - biologic function;novel;Ohio;Patient Self-Report;Performance;physical abuse;Physiology;Prevention;prospective;psychiatric symptom;Psychophysiology;Recording of previous events;recruit;Research Personnel;Risk;Risk Behaviors;Risk Factors;Risk Marker;Sampling;Sexual abuse;Stress;stressor;Surveys;Testing;Time;Trauma;trauma exposure;underage drinking;Work;young adult;Youth

PROJECT_TITLE: Trauma and Neurobiological Threat Reactivity as Risk Factors for Alcohol Abuse in Youth

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Neurosciences;Pediatric;Social Determinants of Health;Substance Misuse

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE Family history of alcoholism and early life adversity (ELA) robustly increase risk for problem alcohol use, however the biological mechanisms responsible have not been elucidated. We propose that family histories of alcoholism and ELA induce blunted hypothalamic-pituitary-adrenal (HPA) stress reactivity, leading to immunologic dysregulation and increased immunoreactivity that impairs myelination and damages axons in developing frontal white matter tracts. The resulting impaired communication to and from the prefrontal cortex contributes to behavioral phenotypic characteristics that increase alcoholism risk.

PI_NAMEs: ACHESON, ASHLEY  (contact);KOCHUNOV, PETER V.;LOVALLO, WILLIAM R;O'CONNOR, JASON C

PROJECT_TERMS: Adrenal Glands;Affect;Alcohol abuse;alcohol use disorder;Alcoholism;anti social;Axon;axon injury;Behavior assessment;Behavioral;behavioral phenotyping;Biological;Blood flow;Cerebrum;Characteristics;Child;Clinical assessments;cognitive performance;Communication impairment;cytokine;Diffusion;disorder risk;Dose;early life adversity;Epigenetic Process;Family;Family Characteristics;Family health status;Family history of;Functional impairment;Funding;Gene Cluster;Gene Expression;Generations;Genes;genome-wide;heuristics;high risk drinking;Human;Hypothalamic structure;Immune;Immune system;Immunologics;Immunology;immunoreactivity;immunoregulation;Impaired cognition;Impairment;Individual;Inflammation;Inflammatory;Intercellular Fluid;Length;Leukocytes;Link;Measures;Methylation;Modeling;multimodal neuroimaging;Myelin;myelination;neural;neural circuit;Neurobiology;neuroimaging;novel;Ontology;Pattern;Persons;Phenotype;Pituitary Gland;Plasma;pre-clinical;Prefrontal Cortex;Recording of previous events;Regulation;response;Risk;stress reactivity;Structure;Testing;Transcript;transcriptomics;white matter;young adult

PROJECT_TITLE: Family Health Patterns: A Study Across Generations


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Substance Misuse

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: NARRATIVE Exosomes are small secreted vesicles that bind to target cells resulting in the delivery into the cells of a molecular “payload” that causes the cells to change their behavior. This grant application seeks to understand the therapeutic actions of exosomes in liver fibrosis or alcoholic liver disease. These studies will establish that exosomes produced by healthy liver cells can reprogram and heal liver cells which have been damaged by exposure to alcohol or that are involved in the production of scar material during chronic injury.

PI_NAMEs: BRIGSTOCK, DAVID R (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Adrenal Cortex Hormones;Affect;Alcohol consumption;alcohol exposure;Alcoholic beverage heavy drinker;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Alternative Therapies;Animals;antagonist;Apoptosis;Applications Grants;Attenuated;Behavior;Binding;Biological Assay;California;Cause of Death;cell injury;Cell surface;Cell Survival;Cells;Cessation of life;Chronic;chronic alcohol ingestion;chronic liver disease;chronic liver injury;Cicatrix;Cirrhosis;Clinic;Coculture Techniques;connective tissue growth factor;cytokine;Data;Deposition;Diet;Disease;Ethanol;exosome;extracellular;Fatty Liver;FDA approved;Fibrillar Collagen;fibrogenesis;Fibrosis;Gene Expression;Goals;healing;Health;Heavy Drinking;Hepatic Stellate Cell;Hepatocyte;Hypoxia;immune function;improved;In Vitro;in vivo;in vivo Model;Incidence;Individual;Inflammatory;Injury;innovation;Integrin alpha5beta1;Integrin alphaVbeta3;Integrins;Intercellular adhesion molecule 1;knock-down;Knowledge;Kupffer Cells;Lead;Ligands;Liver;Liver Cirrhosis;Liver diseases;Liver Fibrosis;MADH3 gene;Mediating;Mediator;Medical;Messenger RNA;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;nanovesicle;National Institute on Alcohol Abuse and Alcoholism;novel;Ohio;Outcome;overexpression;Pathology;Pathway interactions;Patients;Persons;Phenotype;Primary carcinoma of the liver cells;Production;programs;Progressive Disease;promoter;Property;Proteins;receptor;Regulation;Reporter;Risk Factors;Role;side effect;Small Interfering RNA;Testing;Therapeutic;therapeutic candidate;Therapeutic Effect;Therapeutic Uses;Tissues;TNF gene;United States;Universities;Untranslated Regions;Vesicle

PROJECT_TITLE: Therapeutic roles of hepatocyte exosomes in the liver

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]