NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Eating Disorders;Estrogen;Mental Health;Mental Illness;Neurosciences;Nutrition;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Estrogen deficiency is common in R-EDs, which may drive neuroinflammation given the anti-inflammatory effects of estrogen on the brain barrier. This study will use a randomized controlled trial of physiological estrogen to study the impact of estrogen deficiency (and replacement) on the brain barrier and inflammation in R-EDs. The resulting data will greatly increase our understanding of neuroinflammation in R-EDs and facilitate development of novel therapeutic targets.

PI_NAMEs: BREITHAUPT, LAUREN  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Adolescence;Adolescent;Anti-Inflammatory Agents;Antiinflammatory Effect;Area;Autoimmune Diseases;Autopsy;Blood;Brain;Brain imaging;brain parenchyma;career;career development;Central Nervous System;Clinical;clinical translation;Communication;comparison control;Competence;Data;Development;Development Plans;Eating Disorders;epidemiology study;Estrogen deficiency;Estrogen Replacements;Estrogens;extracellular;Female;Funding;Goals;Gonadal Steroid Hormones;Grant;healthy weight;Hormones;Image;Immune;immune function;Immune System Diseases;Immunology;improved;in vivo;Individual;Infection;Inflammation;Inflammatory;inflammatory marker;innovation;K-Series Research Career Programs;Knowledge;Link;Magnetic Resonance Imaging;Maps;Measurable;Measures;Mediating;Mental disorders;Mentors;Mentorship;Multimodal Imaging;National Institute of Mental Health;neuroimaging;neuroinflammation;neuroprotection;Neurosciences;new therapeutic target;non-invasive imaging;novel;novel therapeutics;Outcome;Pathology;patient oriented research;Perfusion;perfusion imaging;Peripheral;Permeability;Physiological;Placebos;Plasma;Population;Production;programs;protein expression;Proteins;Proteomics;Psychoneuroimmunology;Randomized, Controlled Trials;Reaction;Relapse;Research;restrictive eating;Risk;Sampling;Shapes;Structure of choroid plexus;Symptoms;Testing;therapeutic target;Training;translational neuroscience;translational scientist;Water;Weight;Work

PROJECT_TITLE: Estrogen's Neuroprotective Effects on the Brain-Barrier in Restrictive Eating Disorders

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Epilepsy;Eye Disease and Disorders of Vision;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: BAR HARBOR

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE KAND (KIF1A-associated neurological disorder) is a devastating disease diagnosed in childhood and caused by mutations in the KIF1A gene - a microtubule-dependent motor protein that is responsible for axonal transport. Without treatment, children and adults affected by KAND suffer from the progressive loss of their mobility, vision and even early death due to intractable epilepsy and complications of respiratory illness. This proposal aims to generate much needed mouse models that will serve as patient avatars for advancing our understanding of pathophysiology and therapeutic testing.

PI_NAMEs: LUTZ, CATHLEEN M (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Academia;Address;Adult;Affect;Alleles;Atrophic;autism spectrum disorder;Axonal Transport;base editor;Biological Markers;Biology;cell type;Cells;Cessation of life;Child;Childhood;Childhood Neurological Disorder;Clinical;Communities;Data;Defect;design;Development;Developmental Delay Disorders;dimer;Disease;disease diagnosis;disease phenotype;DNA;dominant genetic mutation;effective therapy;efficacy evaluation;experimental study;Functional disorder;gene replacement;Genes;Genetic;Genetic Engineering;genotyped patients;Goals;Heterozygote;Histology;Human;human induced pluripotent stem cells;improved;Industry;insight;Intellectual functioning disability;Intractable Epilepsy;Investigation;Kinesin;Knowledge;Microcephaly;Microtubules;Missense Mutation;Modeling;mortality;Motor;mouse model;Mus;Muscle hypotonia;Muscle Weakness;Mutant Strains Mice;Mutation;mutation correction;Natural History;Nervous System;Nervous System Disorder;Neurologic;neurological pathology;Neurons;novel therapeutics;Optic Nerve;overexpression;Patients;Peripheral Nervous System Diseases;Phase;Phenotype;Preclinical Testing;Prevalence;prime editing;prime editor;Probability;protein function;Proteins;Publishing;Reproducibility;Research;Resources;respiratory;Route;Seizures;Tertiary Protein Structure;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;Time;Transgenic Mice;Validation;Vision;Visual impairment;Work

PROJECT_TITLE: Interrogation of Neurological Pathologies Associated with Mutations in Kif1a

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Rare Diseases;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Many cancers are driven by increased activation of a signaling pathway called WNT. Drugs that block WNT often cause damage to normal organs and have so far been difficult to use in a clinical setting. Here, we will test a new approach that aims to exploits genetic changes in cancer cells and allow cancer-specific suppression of WNT treatment of colorectal cancer.

PI_NAMEs: DOW, LUKAS EDWARD (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Active Immunotherapy;Adult;Advanced Malignant Neoplasm;Animal Model;AXIN1 gene;beta catenin;Biological Models;Body System;bone;Breast Adenocarcinoma;Breast Cancer cell line;cancer cell;Cancer Cell Growth;Cancer cell line;Cancer Model;cancer therapy;cancer type;Cell Proliferation;cell type;Cells;cellular engineering;Chromosome 8;chromosome 8p loss;Chromosome Arm;Chromosome Deletion;Chromosomes;Clinical;Clinical Management;Clustered Regularly Interspaced Short Palindromic Repeats;Colon;Colon Adenocarcinoma;Colorectal Cancer;colorectal cancer treatment;Colorectal Neoplasms;Complex;Data;Dependence;Diploidy;Disease;Disease Progression;Distal;Drug resistance;efficacy evaluation;Engineering;Enzymes;Family member;Gene Silencing;Genes;genetic approach;Genetic Models;Genetic Transcription;Genome;genome editing;Goals;Growth;Heterozygote;Homeostasis;Human;Hyperactivity;Immunocompetent;in vivo;inhibitor;injury and repair;innovation;Intestines;Lead;Link;Lung;Lung Adenocarcinoma;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Modeling;Molecular Target;molecular targeted therapies;mouse model;Mus;Mutation;Normal Cell;Normal tissue morphology;novel;novel strategies;novel therapeutic intervention;Oncogenic;Organ;Organoids;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;pre-clinical;Pre-Clinical Model;precision oncology;preclinical study;Process;Proteins;Proteomics;Regulation;resistance mechanism;response;Safety;Series;Signal Pathway;Signal Transduction;small hairpin RNA;small molecule;small molecule inhibitor;Solid Neoplasm;stem cells;System;Tankyrase;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;tissue regeneration;Tissues;TNKS gene;Toxic effect;TP53 gene;Transgenic Organisms;treatment response;tumor;tumor progression;WNT Signaling Pathway;Work

PROJECT_TITLE: Tumor selective inhibition of the WNT pathway

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The US Preventive Services Task Force (USPSTF) recommends primary care providers screen children and adults for obesity and offer or refer to comprehensive, intensive behavioral interventions (IBTs); however, these recommendations are rarely implemented due to numerous barriers. Our multidisciplinary team of researchers has developed a scalable, multi-faceted implementation strategy, Comprehensive Multidisciplinary Obesity Care (CMOC), which leverages a timely Medicaid policy change, clinical and community linkages, and digital technology, to support the adoption of USPSTF-recommended care through provider training that prioritizes structural and systemic contributors to health inequities to improve weight-related outcomes among youth and adults with obesity. Guided by RE-AIM, this study will evaluate the short- and long-term clinical and implementation outcomes of CMOC compared to implementation-as-usual (control) using a cluster randomized trial with one-way crossover in 20 federally qualified health centers in urban and rural areas of Missouri, providing the data that are needed to support widespread implementation of this approach, if effective, and ultimately improve health outcomes among historically marginalized groups.

PI_NAMEs: HAMPL, SARAH ELIZABETH;WILFLEY, DENISE ELLA (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Adoption;Adult;adult obesity;Affect;Affordable Care Act;arm;Behavior Therapy;behavioral health;Body Weight Changes;Body Weight decreased;care coordination;care fragmentation;Caring;Child;Clinic;Clinical;clinically significant;Cluster randomized trial;cohort;Communities;community clinical linkage;Community Health Aides;community partners;community setting;Competence;contextual factors;cost;Cost Savings;Counseling;Data;Detection;Diagnosis;Dietitian;digital technology;disability;Discipline;Disease;Education;Effectiveness;effectiveness/implementation design;Electronic Health Record;Eligibility Determination;Equity;Evaluation;evidence base;Evidence based treatment;Federally Qualified Health Center;Future;gaps in access;Health;health care service utilization;health inequalities;Health Personnel;Health Policy;Health Services Accessibility;Health system;implementation barriers;implementation outcomes;implementation strategy;improved;Inequity;Infrastructure;innovation;Intervention;Learning;Life Expectancy;Link;Low income;Maintenance;marginalized population;Medicaid;Medical;Methods;Missouri;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Nutritionist;obese patients;Obesity;Obesity Epidemic;obesity in children;obesity treatment;Outcome;Patient Care;Patients;payment;Perception;Phase;Policies;Population;population health;Preventive service;primary care provider;programs;Provider;Quality of Care;Quality of life;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Research;Research Personnel;rural area;Rural Community;screening;service delivery;Services;social;social health determinants;social stigma;socioeconomics;Training;Training Programs;Translations;United States Preventative Services Task Force;urban area;Weight;Work;Youth

PROJECT_TITLE: Increasing Access to USPSTF-Recommended Obesity Care for Youth and Adults Who Are Recipients of Medicaid: Evaluation of a Comprehensive Multidisciplinary Obesity Care Training Program in FQHCs

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Liver Disease;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The Michigan team proposes to continue to enroll high causality DILI cases using a multi-faceted recruitment strategy involving new co-investigators and sites at Michigan Medicine as well as continued collaboration with other major medical centers and members of the highly successful Michigan Hepatotoxicity Network. The enrollment of high causality DILI cases of varying age, gender, and ethnicity will allow us to conduct new genetic, immunophenotyping, and biomarker ancillary studies focused on DILI pathogenesis. We also propose a series of outreach and educational efforts to help DILIN become a pharmacovigilance beacon for new causes of drug and HDS hepatotoxicity in the United States and lastly we propose a pilot clinical trial of budesonide in patients with severe acute hepatocellular DILI with jaundice to improve patient outcomes.

PI_NAMEs: FONTANA, ROBERT J (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Acute;Age;Algorithms;Alleles;Amoxicillin-Potassium Clavulanate Combination;Analytical Chemistry;Ancillary Study;Applications Grants;biobank;Biological;Biological Assay;Biological Markers;Biomedical Engineering;Black race;Blood specimen;Budesonide;cell type;Cells;Childhood;Clinical;Clinical Data;Clinical Research;clinical trial protocol;Clinical Trials;cohort;Collaborations;Collection;cost;COVID-19;Data;design;Development;Diagnostic;diagnostic accuracy;DNA;Dose;Drug Screening;Early Diagnosis;Education;Education and Outreach;efficacy evaluation;elastography;Electronic Mail;Electronics;Endothelial Cells;Enrollment;ethnic minority;Ethnic Origin;Etiology;Event;Exclusion Criteria;experimental study;Feasibility Studies;follow-up;Fractionation;Funding;Gender;Generations;Genetic;Genetic Predisposition to Disease;genome wide association study;Genomics;Genotype;Goals;Grant;Hepatitis;Hepatitis C virus;Hepatocyte;Hepatotoxicity;high throughput screening;Hispanic;Human;Icterus;Immunologic Factors;Immunophenotyping;improved;In Vitro;Individual;individual patient;induced pluripotent stem cell;Inflammatory;injury recovery;insight;instrument;International;Intervention Studies;Laboratories;Liver;liver injury;Logistics;Medical center;Medicine;member;metabolomics;Michigan;minority patient;Modeling;Molecular;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Natural Products;novel;open label;operation;Oral;Organoids;Outcome;participant enrollment;Pathogenesis;patient derived induced pluripotent stem cells;Patient-Focused Outcomes;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacovigilance;Phenotype;Physicians;Physiological;polygenic risk score;Predisposition;Professional Organizations;prognostic;Prospective Studies;Protocols documentation;PTPN22 gene;Publications;Race;recruit;Registries;Reporting;Research;Research Personnel;response;Retrospective Studies;Risk Factors;RNA vaccine;Safety;Sampling;Secure;Series;Serum;Site;Spain;Standardization;Steroids;Stress;System;Testing;Tissues;tool;transcriptomics;Twitter;United States;Universities;Update;web site;Work

PROJECT_TITLE: Michigan Hepatotoxicity Clinical Research Network Renewal


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE The goal of this proposal is directly to bridge the gap between the enormous volumes of data generated by the comprehensive molecular characterization of a number of cancer types– and the ability to use these data for the development of human cancer therapeutics.

PI_NAMEs: BANDYOPADHYAY, SOURAV ;BIVONA, TREVER G;MCMANUS, MICHAEL T (contact)

PROGRAM_OFFICER_NAME: MCCARTHY, CLAIRE ELLEN

PROJECT_TERMS: Area;Automobile Driving;Benign;Biogenesis;Biological;Breast Adenocarcinoma;Calibration;cancer cell;Cancer cell line;cancer subtypes;cancer type;cell behavior;Cell Culture Techniques;cell transformation;cell type;Cells;Clinical;clinical translation;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Data;Development;Distal;Drug resistance;Drug Targeting;Drug Tolerance;Epigenetic Process;Event;Evolution;Exhibits;Fertilization;Foundations;Funding;Gene Combinations;Genes;Genetic;Genetic Screening;Genotype;Goals;Growth;Heterogeneity;high throughput technology;Human;improved;In Vitro;in vivo;Inflammatory;innovation;insight;Joints;Lung Adenocarcinoma;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Methodology;Modeling;Molecular;Molecular Target;mouse model;Mutation;neoplastic cell;next generation;novel;novel therapeutics;Oncogenes;Pathogenicity;Pathway interactions;patient derived xenograft model;patient stratification;pharmacologic;Phenotype;Phylogenetic Analysis;premalignant;Process;programs;Reagent;Recurrence;Research;Research Project Grants;Resistance;Resolution;Role;single-cell RNA sequencing;Solid;synergism;synthetic biology;Synthetic Genes;System;Systems Biology;Technology;The Cancer Genome Atlas;Therapeutic;therapeutic target;therapeutically effective;therapy resistant;Time;Tissues;tool;treatment response;tumor;tumor growth;tumor heterogeneity;Tumor Suppressor Genes;tumorigenesis;Work

PROJECT_TITLE: Bay Area Cancer Target Discovery and Development


ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: NARRATIVE There is a strong relationship between adipose tissue and the risk of diseases such as Type 2 Diabetes, fatty liver and heart disease. However, adipose tissue plays many beneficial functions, and healthy adipose tissue can actually protect from metabolic diseases. Adipose tissue health means that all the types of adipose tissues present in the body function correctly. During fasting, adipose tissue must be able to provide muscles, heart and liver with sufficient fuel to maintain blood glucose levels. Also, a distinct type of adipose tissue, called beige or brown, must be present to help control body temperature. Beige fat also has the capacity to burn calories and secrete hormones that improve metabolism. The proper functions of adipose tissues are controlled by the brain, which detects the need for fuel, or the outside environmental conditions. The brain communicates to adipose tissues via nerves, which secrete a neurotransmitter called noradrenaline. We have found that human fat cells have an enzyme, called MAOA, that can degrade noradrenaline. The levels of this enzyme in adipocytes can have a great impact on how the brain communicates not only to adipocytes, but to organs surrounded by adipose tissue such as the heart and major blood vessels. To study the importance of this enzyme we developed a unique model in which we can grow human fat in mice. Our current results suggest that MAOA in human adipocytes can control adipocyte beiging, and is therefore probably very important in controlling whole body metabolic rate. The studies proposed in this grant will determine whether human adipocyte MAOA can affect the levels of noradrenaline sufficiently to affect adipose tissue function and influence propensity for weight gain and glucose metabolism. If we find that human adipocyte MAOA is capable of affecting metabolic rate, we will design ways to target its activity to improve weight loss and ameliorate metabolic diseases such as type 2 diabetes, fatty liver and heart disease.

PI_NAMEs: CORVERA, SILVIA  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Acceleration;Adipocytes;Adipose tissue;Adrenergic Agents;Adrenergic Receptor;Affect;anti-depressive agents;Basal metabolic rate;Biological Availability;Blood Glucose;blood glucose regulation;Blood Vessels;Body Temperature;Body Weight decreased;Brain;Calories;Cells;Closure by clamp;Communication;comparison control;CRISPR/Cas technology;Cues;Dependence;design;Development;disorder risk;Enzymes;Experimental Models;Exposure to;Fasting;Fatty acid glycerol esters;Fatty Acids;fatty liver disease;Forms Controls;Genes;glucose disposal;glucose metabolism;Grant;Health;Heart;Heart Diseases;Homeostasis;Hormone secretion;Human;Human body;Hybrids;Hyperglycemia;Immunocompromised Host;Implant;implantation;improved;in vivo;insulin sensitivity;knock-down;Knock-out;Lipolysis;Liver;Measures;Mediating;Mesenchymal Stem Cells;Metabolic;Metabolic Diseases;metabolic rate;Metabolism;Methodology;Modeling;monoamine;Monoamine Oxidase A;Mus;Muscle;nanoparticle;Nerve;nerve supply;Neurons;Neurotransmitters;Non-Insulin-Dependent Diabetes Mellitus;Norepinephrine;novel;novel strategies;novel therapeutics;NRIP1 gene;Obesity;Organ;Organ Temperatures;overexpression;pharmacologic;Physiological;Play;Positioning Attribute;Predisposition;Probability;Proteins;Recycling;Respiration;response;Role;Signal Transduction;Site;stem cell differentiation;Stimulus;subcutaneous;Techniques;Technology;Testing;Therapeutic;Thermogenesis;Tissues;Vascularization;virtual;Weight Gain;Work

PROJECT_TITLE: Human adipose tissue in control of sympathetic tone and metabolic rate

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: LM

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD);Telehealth

ORG_CITY: MILWAUKEE

ORG_NAME: UBITRIX INTERNATIONAL, INC.

ORG_STATE: WI

PHR: PROJECT NARRATIVE In this project, we aim to develop a Framework for mHealth App Security and Privacy Analysis called mSPAiOS intended to check the security and privacy of Android and iOS applications. The project is a further extension of our preliminary prototype developed from the STTR Phase I project, where android-based mHealth apps are checked for HIPAA-related technical security and privacy rules at the source code level for app users and developers. The Phase II commercial product aims to further extend the Phase I product by increasing language support for security and privacy checking, providing plugins support for developers in an integrated developed environment for Android and iOS, and testing more production-grade applications that are developed and maintained by at least 3 USA-based health IT companies/vendors. Moreover, this project will advance the secure EHR/EMR vendor integration via API with mHealth apps. The project has further implications of preventing several emerging and existing cyber-attacks that can potentially lead to massive healthcare data breaches, such as ransomware, and supply chain attacks, by detecting and preventing the vulnerabilities early.

PI_NAMEs: AHAMED, SHEIKH IQBAL (contact)

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Address;Algorithms;Android;Apple;Appointments and Schedules;Area;Awareness;Behavior;Businesses;Cellular Phone;Code;Collaborations;Computer software;computerized data processing;Data;data communication;data exchange;data interoperability;Data Security;data sharing;Dedications;Development;Devices;Effectiveness;electronic health record system;encryption;Environment;Evaluation;evaluation/testing;FDA approved;Guidelines;handheld mobile device;Health;health data;Health Insurance Portability and Accountability Act;Health Personnel;Health protection;Healthcare;improved;International;Java;Knowledge;Language;Link;Marketing;Medical;Medical History;Medical Records;Methods;mHealth;mobile application;Mobile Health Application;Monitor;Names;non-compliance;Online Systems;Outcome;Patients;Performance;Phase;Play;Plug-in;Policies;prevent;Privacy;Privatization;Probability;Production;Programming Languages;Protocols documentation;prototype;Provider;Pythons;Regulation;remote health care;Reproduction;Research;Research Personnel;Risk;Sample Size;seal;Secure;Security;sensor;Side;Small Business Technology Transfer Research;smartphone application;Source Code;success;supply chain;support tools;Techniques;Testing;tool;transmission process;United States Centers for Medicare and Medicaid Services;Universities;Vendor;virtual;web based interface;web site

PROJECT_TITLE: A Framework for mHealth App Security and Privacy Analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-J(10)B]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Prevention;Substance Misuse;Tobacco

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE  The co-use of nicotine/tobacco products and cannabis among young adults is prevalent and may adversely affect treatment and other clinical outcomes, yet little is known regarding the treatment implications of co-use and the underlying relationship between substances. The overall goal of this project is to characterize and evaluate the underlying relationship between nicotine and cannabis and its impact on nicotine/tobacco cessation through a behavioral economics framework to determine how impactful cannabis co-use may be on nicotine cessation and which individuals who co-use experience greater difficulty achieving cessation. Findings from this proposed R01 will be positioned to have substantial impact on treatment recommendations for young adults who are using nicotine/tobacco products and co-using cannabis to provide them with the best chances of successful and sustained abstinence.

PI_NAMEs: MCCLURE, ERIN A (contact)

PROGRAM_OFFICER_NAME: REYES-GUZMAN, CAROLYN

PROJECT_TERMS: Abstinence;Address;adverse outcome;Affect;Age;age group;Behavioral;behavioral economics;Biochemical;Biological Markers;Cannabis;Cigarette;Clinical;clinical care;Collaborations;Collection;contingency management;Data;diaries;Evaluation;experience;Goals;Health;Individual;Individual Differences;individualized medicine;innovation;Intervention;Liquid substance;Literature;marijuana use;Measures;Medical;Methods;Nicotine;nicotine cessation;nicotine treatment;nicotine use;Oral;Outcome;Participant;Patient Self-Report;Pattern;Pharmaceutical Preparations;Positioning Attribute;Prevalence;prolonged abstinence;prospective;Prospective Studies;Public Health;Publishing;Recommendation;recruit;remote administration;Research;Role;Sampling;secondary analysis;Smoking;South Carolina;substance use;success;Time;Tobacco;tobacco products;Tobacco Use Cessation;Treatment outcome;United States;Universities;vaping;vaping nicotine;virtual therapy;Withdrawal;young adult;Youth

PROJECT_TITLE: The impact of cannabis and tobacco/nicotine product co-use in young adults: Prospective cessation evaluation and substitution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-P(02)M]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Digestive Diseases;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The NIH Artificial Intelligence Working Group recently challenged the medical community to train researchers in both healthcare and computer science, proposing that dual training is fundamental to advance artificial intelligence into healthcare and assure these models are safe, interpretable, and effectively integrated into real- world systems. Acute gastrointestinal bleeding is the most common cause of hospitalization for gastrointestinal diseases and many patients are unnecessarily hospitalized. A symptom-based risk assessment tool is more clinically useful than existing scores; this can be developed with deep learning approaches and deployed on the electronic health record to decrease unnecessary and costly hospitalizations.

PI_NAMEs: SHUNG, DENNIS  (contact)

PROJECT_TERMS: Accident and Emergency department;Acute;Acute Renal Failure with Renal Papillary Necrosis;acute symptom;Algorithms;Artificial Intelligence;Assessment tool;base;Blood;Boston;Caring;Charge;Clinical;Clinical Data;clinical decision support;Clinical Investigator;clinical practice;clinical risk;Clinical Trials Design;Collection;Communities;computer science;Computers;Cost Savings;Data;data modeling;Data Set;Databases;deep learning;deep learning algorithm;deep learning model;design;Diagnosis;Education;Electronic Health Record;electronic health record system;Erythrocyte Transfusion;feasibility testing;Feces;field study;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal Hemorrhage;gastrointestinal symptom;Goals;health assessment;Health system;Healthcare;Hematochezia;Hemorrhage;Hemostatic Agents;Hospital Costs;Hospitalization;Hospitals;implementation science;insight;Intervention;Learning;Length of Stay;Location;longitudinal analysis;Lower Gastrointestinal Tract;Machine Learning;machine learning algorithm;machine learning model;machine learning prediction;Massachusetts;Medical;Medical center;Melena;Mentors;Mentorship;Modeling;neural network;Outcome;outcome prediction;Outpatients;patient health information;Patient risk;patient stratification;Patient Triage;Patient-Focused Outcomes;Patients;Performance;Pilot Projects;point of care;predictive modeling;Process;prognostic algorithm;progression risk;prospective;Provider;Recommendation;Reporting;Research;Research Personnel;Resources;Risk;Risk Assessment;risk stratification;Sepsis;Site;Source;Standardization;Symptoms;System;Time;time use;tool;tool development;Training;Transfusion;transmission process;United States National Institutes of Health;Update;Validation;wasting;Work;working group

PROJECT_TITLE: Deep Learning Approaches to Risk Stratification in Acute Gastrointestinal Bleeding

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Transplantation

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Renal transplants from deceased African American kidney donors do not function as long as those from deceased European American kidney donors; reasons for this are unknown, but retrospective reports suggest that donors having kidney disease risk variants in the apolipoprotein L1 (APOL1) gene may contribute. The Wake Forest APOL1 Long-term Kidney Transplant Outcomes Network (APOLLO) Clinical Center has prospectively evaluated effects of donor and recipient APOL1 genotypes in kidney transplants performed at our aligned transplant programs. Results from our Clinical Center, part of the national APOLLO study, could help transform organ allocation and informed consent in kidney transplantation, optimize survival of patients after kidney transplantation, and determine the safety of living kidney donation.

PI_NAMEs: GBADEGESIN, RASHEED ADEBAYO;REEVES-DANIEL, AMBER  (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: 2019-nCoV;Acceleration;Acute;Address;African American;African American population;African ancestry;Albumins;Allografting;American;Antibodies;APOL1 gene;Apolipoproteins;Bacterial Infections;Biopsy;Blood;Clinical;clinical center;Clinical Data;cohort;Consent;Cost Savings;Counseling;Creatinine;Cytomegalovirus;Data;digital pathology;Disparity;DNA;Donor person;donor-specific antibody;Education;Eligibility Determination;End stage renal failure;Enrollment;Ensure;Environmental Risk Factor;ethnic difference;European;Evaluation;Face;Failure;follow-up;Funding;Genes;Genetic;genetic risk factor;Genotype;Geography;graft failure;graft function;Graft Survival;Health;Health Care Costs;Health protection;Heart Atrium;high risk;Histology;HLA Antigens;Immunosuppression;improved;Individual;Informed Consent;Ischemia;Kidney;kidney allograft;kidney biopsy;Kidney Diseases;Kidney Failure;Kidney Transplantation;Lesion;Living Donors;living kidney donor;Longterm Follow-up;Measures;Medical;novel;Organ;organ allocation;Outcome;Participant;Patients;Pattern;Pharmaceutical Preparations;Phase;Phenotype;Physicians;Policies;Population;Population Group;post-transplant;Prevalence;primary outcome;Process;programs;prospective;Proteinuria;Protocols documentation;Quality of life;racial difference;recruit;Recurrent disease;Registries;Renal function;Reporting;repository;Research;Risk;risk variant;Role;Safety;secondary outcome;Serum;Site;Slide;Time;Transplant Recipients;Transplantation;United Network for Organ Sharing;United States National Institutes of Health;Urine;Variant;Virus Diseases;Work

PROJECT_TITLE: 13/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Celiac Disease;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Mental Health;Nutrition;Pediatric;Prevention

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE The primary objective of this research proposal is to refine and test the first behavioral intervention for teens with celiac disease and their parents. Celiac disease affects up to one in fifty individuals and increases risk of costly and negative health consequences such as cancers, additional autoimmune diseases, and a two-fold increase in risk of death unless a strict gluten-free diet can be achieved (the only treatment currently available). The proposed study has the potential to reduce these complications by addressing psychosocial challenges that may interfere with quality of life and gluten-free diet management during adolescence, a critical developmental period for optimizing long-term mental and physical health across the lifespan.

PI_NAMEs: COBURN, SHAYNA SKELLEY (contact)

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affect;Age;Anxiety;Applications Grants;Attention deficit hyperactivity disorder;Autoimmune Diseases;Behavior;Behavior Therapy;Behavioral;Bread;Butter;career;Caring;Celiac Disease;Characteristics;Child;Childhood;Chronic;Chronic Disease;Clinical;Cognitive;Communities;comparison control;Control Groups;Coping Behavior;Coping Skills;cost;critical developmental period;Data;design;Diabetes Mellitus;Diet;dietary adherence;Digestive System Disorders;digital technology;disease diagnosis;Disease Management;Distress;Education;efficacy trial;emotional distress;Evaluation;experience;Family;Feedback;Focus Groups;follow-up;Food;Fright;Funding;Future;Gluten;Gluten-free diet;Goals;Grant;group intervention;Health;Hospitals;Hour;immunogenic;improved;Individual;Inflammatory Bowel Diseases;innovation;Institution;Intervention;intervention refinement;Intervention Trial;Interview;Intestinal Cancer;Knowledge;life span;Link;Malignant Neoplasms;Measures;Medical Research;Mental Depression;Mental disorders;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Mission;Modeling;mortality;mortality risk;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Hodgkin's Lymphoma;nutrition education;Obesity;Outcome;Outcome Measure;Parents;Participant;patient oriented;Peptides;Persons;Phase;Phase Ib Trial;physical conditioning;Physicians;Positioning Attribute;post intervention;primary outcome;programs;psychological symptom;psychosocial;Psychosocial Assessment and Care;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;research data dissemination;Research Methodology;Research Personnel;Research Proposals;Research Training;Risk;satisfaction;Science;secondary outcome;Secure;Self Efficacy;Self Management;Series;skills;social;Social isolation;Source;Standardization;Statistical Data Interpretation;Structure;Techniques;Technology;Teenagers;telehealth;Testing;Text;Text Messaging;theories;Training;training opportunity;treatment as usual;Treatment Efficacy;Work;Writing;Youth

PROJECT_TITLE: A behavioral intervention to optimize self-management of celiac disease in adolescents


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DETROIT

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Narrative Retinal neurons sense diverse types of images, including a direction of a moving object. The mechanisms of sensing the direction by retinal neural networks have been investigated for decades; however, it has not been fully understood. We will test our hypothesis that acetylcholine, a neurotransmitter, contributes to motion prediction to accelerate sensing a moving object.

PI_NAMEs: ICHINOSE, TOMOMI  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Acceleration;Acetylcholine;Affect;Amacrine Cells;Animals;behavioral study;Calcium;Cells;cholinergic;Code;Computer Models;Computer Simulation;Dendrites;Detection;Diameter;Environmental Impact;Environmental Risk Factor;Feedback;ganglion cell;Image;Immunohistochemistry;Knowledge;Light;Mediating;meter;Molecular;Motion;motion sensitivity;Mus;neural network;Neural Retina;Neurons;neurotransmission;Neurotransmitters;Nicotinic Receptors;object motion;Outcome;patch clamp;Pathway interactions;Presynaptic Terminals;Reaction;Reaction Time;receptive field;Retina;retinal neuron;signal processing;Signal Transduction;Speed;starburst amacrine cell;Stimulus;Testing;Tissues;two-photon;Visual

PROJECT_TITLE: Mechanisms of Motion Detection in Retinal Neural Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-F(02)M]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Aging;Biotechnology;Dental, Oral, and Craniofacial Disease;Gene Therapy;Genetics;Immunotherapy

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: NARRATIVE Cellular senescence is a key but poorly understood determinant of organismal aging. Our proposal aims to identify surface molecules of senescent cells in aging which will allow us to image, isolate and characterize them. By harnessing cellular therapy directed against these surface targets we aim to flexibly interrogate senescence biology in aging and develop a new treatment modality for age-related diseases.

PI_NAMEs: AMOR VEGAS, CORINA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Acceleration;Advisory Committees;Affect;age related chronic disease;Age related pathologies;age-related disease;aged;Aging;aging related;Area;base;Biological;biological adaptation to stress;Biology;Biology of Aging;CAR T cell therapy;career;career development;Cell Aging;Cell Cycle Arrest;Cell secretion;Cell surface;Cell Therapy;Cells;Characteristics;chimeric antigen receptor T cells;Chronic;Collaborations;collaborative environment;cytokine;Data;Development;Educational workshop;Environment;Enzymes;experience;Faculty;Feedback;flexibility;Foundations;Freedom;Functional disorder;gene repression;Genes;Genetic Transcription;Goals;graduate school;graduate student;Grant;health economics;Homeostasis;HRK gene;Image;imaging study;Immune;immune clearance;Immune system;Immunologic Surveillance;immunosenescence;in vivo;inflammatory milieu;innovation;insight;Institution;intravital imaging;Laboratories;Leadership;leadership development;Learning;life span;meetings;member;Mentors;Methods;Modality;Molecular;Monitor;mouse model;novel;older patient;Organism;paracrine;Pathogenesis;Pathologic;Pathology;Play;Positioning Attribute;Pre-Clinical Model;preclinical study;professor;programs;Proliferating;Proteomics;Recording of previous events;recruit;Research;Research Personnel;Resolution;Resource Sharing;Resources;Role;Scientist;selective expression;senescence;senescence associated secretory phenotype;senescent cell;senolytics;skills;socioeconomics;Solid;success;supportive environment;Surface;symposium;Technology Transfer;Therapeutic;therapy design;Time;Tissues;tool;TP53 gene;Training;Tumor Suppression;Tumor Suppressor Proteins;Work;wound healing;Writing

PROJECT_TITLE: Deconstructing aging with senolytic CAR T cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE This implementation science study will test a youth-tailored intervention to improve HIV prevention and HIV care continuum for vulnerable youths at risk of HIV or living with HIV across West, East, and Southern African countries.

PI_NAMEs: ADEBAJO, SYLVIA ;CHARURAT, MANHATTAN E (contact);HIGHTOW-WEIDMAN, LISA B

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Acceleration;Address;Affect;Africa;Africa South of the Sahara;African;Age;AIDS prevention;Baltimore;Behavioral;biosecurity;care systems;Case Management;Cellular Phone;Centers for Disease Control and Prevention (U.S.);Centers for Population Health;Characteristics;Clinical effectiveness;clinical implementation;Clinical Management;Clinical Research;Collaborations;Communities;community advisory board;community engagement;Community Health;Consolidated Framework for Implementation Research;Continuity of Patient Care;cost effectiveness;Country;Cybersex;Data;Data Analyses;data management;data quality;design;Development;digital health;Doctor of Medicine;Doctor of Philosophy;effectiveness evaluation;effectiveness/implementation study;Epidemic;epidemic response;Equity;experience;follow-up;Fortification;gender minority youth;Goals;Guidelines;Health;Health education;Health Services;Health system;High Prevalence;HIV;HIV Infections;HIV Seropositivity;Human;Implementation readiness;implementation science;implementation strategy;implementation/effectiveness;improved;Incidence;Interdisciplinary Study;International;international center;Internet;Intervention;Kenya;Knowledge;Leadership;Malawi;man;Maryland;Morbidity - disease rate;mortality;multidisciplinary;Nigeria;Outcome;outreach;peer;Penetration;Persons;Policies;Policy Making;pre-exposure prophylaxis;Prevention;Prevention Research;Process;programs;provider adoption;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recommendation;Research;resilience;Resources;Risk;Risk Reduction;Role;Scientist;seropositive;service delivery;service providers;Services;Sex Behavior;Sexual and Gender Minorities;sexual minority youth;sexual role;Shapes;Site;social;social stigma;Southern Africa;Strategic Planning;System;Testing;transgender women;Translating;treatment as usual;trial design;United States;Universities;uptake;USAID;Viral Load result;virology;Vision;Work;young men who have sex with men;Youth;Zambia

PROJECT_TITLE: Resilient HIV Implementation Science with Sexual and Gender Minority Youths using Evidence (RISE) Clinical Research Center


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE This prospective international SIOPE/CONNECT phase-III study to improve neurocognitive outcomes in young children with low-risk medulloblastoma (YCMB-LR) is one of the first to prospectively include new biological information into the risk prediction of Medulloblastoma (MB) by intensive molecular profiling and pathway analysis to compare two highly effective irradiation-sparing treatment regimens (Head Start 4 and HIT-SKK) in young patients with low-risk early childhood MB treated at European and North American pediatric oncology centers in terms of neurocognitive, developmental and QoL outcomes at diagnosis and again at 2.5 years post diagnosis. The goal of this research project is to define the new “gold standard” of treatment in early childhood, clarifying which of the two compared regimens, both highly effective for brain tumor control, is associated with better functional outcomes within the domains of overall intelligence, working memory, processing speed, executive functioning, visual-motor integration, and fine motor dexterity, in addition to overall quality of life and several domains of adaptive and emotional functioning, while simultaneously improving and harmonizing international diagnostic and therapeutic standards not only for MB, but also for other pediatric CNS tumors.

PI_NAMEs: SANDS, STEPHEN ALAN (contact)

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: 15 year old;2 year old;5 year old;Adaptive Behaviors;Adjuvant Therapy;Age;Agreement;American;arm;Autologous;Behavioral;behavioral outcome;Biological;Biological Markers;Biology;Brain;Brain Neoplasms;brain volume;Cancer Etiology;Cause of Death;Cells;Central Nervous System;Central Nervous System Neoplasms;Cessation of life;chemotherapy;Child;Childhood;Childhood Brain Neoplasm;Childhood Central Nervous System Neoplasm;Childhood Leukemia;Childhood Malignant Brain Tumor;Childhood Medulloblastomas;clinically relevant;Correlation Studies;Data;Development;dexterity;Diagnosis;Diagnostic;Dose;early childhood;Education;Eligibility Determination;emotional functioning;Europe;European;Excision;executive function;functional outcomes;Funding;Goals;Guidelines;Head Start Program;Hematopoietic;High Dose Chemotherapy;high risk population;improved;Incidence;Infant;Intelligence;International;Intravenous;Intraventricular;irradiation;Language;Late Effects;life span;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Medical center;Medulloblastoma;Methotrexate;Molecular Profiling;Motor;Nervous System Trauma;Neurocognitive;Neurocognitive Deficit;neurocognitive test;Neurologic Deficit;Neuropsychological Tests;Neuropsychology;neurosurgery;Newly Diagnosed;Nonmetastatic;North America;novel therapeutics;Nursery Schools;Outcome;Pathogenesis;Pathway Analysis;Patients;Pediatric Oncology;phase 3 study;processing speed;Prognosis;Progression-Free Survivals;prospective;Protocols documentation;Quality of life;quantitative imaging;Randomized;Regimen;Research Project Grants;research study;Risk;risk prediction;Secure;SHH gene;Short-Term Memory;Site;social;Societies;standard care;standard measure;Standardization;Survival Rate;Survivors;survivorship;Testing;Therapeutic;Time;Translating;treatment arm;Treatment Protocols;tumor;visual-motor integration;Vocation;white matter injury;Work

PROJECT_TITLE: Prospective international phase-III study to improve neurocognitive outcomes in young children with low-risk medulloblastoma (YCMB-LR)

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ORG_CITY: BOSTON

PHR: PROJECT NARRATIVE An urgent need exists to promote and retain investigators from underrepresented backgrounds in the scientific areas supported by NIDDK. This project supports a comprehensive mentoring program for underrepresented investigators already funded by NIDDK that will provide multi-level mentoring, hands-on guidance in grant and manuscript writing, and a curriculum to ensure the skills necessary for academic success.

PI_NAMEs: STANFORD, FATIMA CODY (contact);STANLEY, TAKARA LEAH

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Academia;academic preparation;Academic skills;Acceleration;Address;Applications Grants;Area;Award;Biomedical Research;career;career development;Career Mobility;clinical care;Collaborations;Communication;Communities;design;Development Plans;Educational Curriculum;Educational workshop;Ensure;Equity;ethnic diversity;experience;Face;Faculty;faculty mentor;Feedback;Funding;Future Generations;Goals;Grant;Growth;improved;Individual;Institution;Instruction;Lead;Leadership;Manuscripts;meetings;Mentors;Mentorship;Minority Groups;Minority Health Research;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;nutrition;Obesity;Output;Patient Care;peer;peer coaching;Peer Group;Physicians;Population Heterogeneity;Positioning Attribute;Preparation;Problem Solving;Program Development;programs;racial diversity;recruit;Research;Research Personnel;role model;Scholars Program;Scientist;skills;success;Underrepresented Populations;United States;Vision;Work;Writing

PROJECT_TITLE: Accelerating Research Advancement for Investigators Underrepresented in Academia


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PONCE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PONCE SCHOOL OF MEDICINE

ORG_STATE: PR

PHR: Identifying signaling pathways that correlate deregulated mitotic kinases with metastasis will reduce breast cancer health disparities by targeting mitotic kinases to prevent early metastatic progression in NHB, C-H/L, and other H/L breast cancer patients. The investigators propose to elucidate these pathways using cell lines, organoids, and PDX models of breast cancer established from H/L patients and to validate on a novel TMA established by the Puerto Rico Bio Bank.

PI_NAMEs: CRESS, WILLIAM DOUGLAS;SAAVEDRA, HAROLD I (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Address;African;African ancestry;Age;Aggressive behavior;Aneuploidy;aurora kinase;Automobile Driving;biobank;Biological Markers;Biological Response Modifier Therapy;Black Populations;Black race;black women;Breast Cancer Patient;breast cancer survival;cancer cell;Cancer Center;cancer health disparity;Caribbean Hispanic;Caribbean region;Cell Line;Cell Survival;Cells;Centrosome;Cessation of life;Chromosomal Instability;Chromosomes;Clinical;combinatorial;Copy Number Polymorphism;Cuban;Data;Diagnosis;Disparity;DNA sequencing;Dominican;E-Cadherin;epithelial to mesenchymal transition;Estrogens;ethnic disparity;Ethnic Origin;European;European ancestry;experimental study;Functional disorder;Gene Expression Profile;Generations;Genetic Transcription;Genome;Genomics;Goals;Growth;high risk;Hispanic;improved;Incidence;Individual;inhibitor;Invaded;Laboratories;Latina Population;Latino;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Measures;Mesenchymal;Messenger RNA;migration;Mitotic;Molecular;mortality risk;Nature;Neoplasm Metastasis;Not Hispanic or Latino;novel;novel therapeutic intervention;Organoids;Outcome;overexpression;Pathology;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Phosphorylation;Phosphotransferases;Prevalence;prevent;Principal Investigator;Probability;Progesterone;Prognosis;Proliferating;Publishing;Puerto Rican;Puerto Rico;Race;racial disparity;racial diversity;receptor;recruit;Relapse;Research Personnel;response;Risk Factors;Sampling;Signal Pathway;slug;Socioeconomic Status;stemness;survival outcome;Survival Rate;TBK1 gene;Testing;The Cancer Genome Atlas;Tissue Microarray;transcription factor;transcriptome sequencing;Treatment outcome;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor heterogeneity;tumor initiation;Tumor Markers;Tumor stage;United States;Vimentin;White Women;whole genome;Woman

PROJECT_TITLE: Targeting centrosome‐mitotic kinases as a novel therapeutic approach against breast cancers in Hispanic/Latinas.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Despite the achievements in HIV care and prevention, HIV infection requires uninterrupted therapy to prevent disease progression, and its epidemic still poses a severe burden for global public health. HIV persists in the human host because infected cells divide, resulting in clones that carry HIV genomes. As part of NIH's mission to end the HIV epidemic, this project seeks to understand the ways adaptive immunity contributes to the proliferation of infected cells, which may lead to new strategies to control HIV without the requirement for lifelong treatment.

PI_NAMEs: SIMONETTI, FRANCESCO ROBERTO (contact)

PROJECT_TERMS: Acceleration;Achievement;adaptive immune response;adaptive immunity;anti-fungal agents;Anti-Retroviral Agents;Antigens;antiretroviral therapy;Automobile Driving;Award;Candida;Candida albicans;career;career development;Caring;CD4 Positive T Lymphocytes;Cell division;Cell Survival;Cells;Chronic;chronic infection;clinical training;Clonal Expansion;Clone Cells;Collaborations;commensal microbes;Communication;Cytomegalovirus;decay acceleration;Decision Making;Dedications;design;Development;Disease Progression;Disease remission;DNA;Doctor of Philosophy;Educational process of instructing;effective intervention;Epidemic;Equipment;Event;Evolution;experience;experimental study;Exposure to;Faculty;Funding;Goals;graduate school;Health system;HIV;HIV Antigens;HIV Genome;HIV Infections;HIV-1;Homeostasis;Human;immune clearance;Immune response;Immune system;Immunologic Factors;In Vitro;in vivo;Individual;Infection;innovation;insight;Institution;interest;Interruption;Knowledge;Learning;Life;lonely individuals;Maintenance;Measures;Medicine;member;Mentors;Mission;Morbidity - disease rate;mortality;National Cancer Institute;National Institute of Allergy and Infectious Disease;next generation;novel therapeutic intervention;Outcome;Paper;pathogen;Pathogenicity;Pennsylvania;Persons;Pharmaceutical Preparations;Physiological;Play;Population;Postdoctoral Fellow;pressure;prevent;Prevention;Principal Investigator;Process;professor;programs;Proliferating;Proteins;Public Health;Publishing;purge;Research;Role;Running;Science;Scientist;senior faculty;Shapes;skills;Source;Structure;Student recruitment;Students;T cell reconstitution;T-Cell Proliferation;T-Lymphocyte;Testing;Time;tool;Training;undergraduate student;United States National Institutes of Health;Universities;Viral;viral rebound;Virus;Work;Yeasts

PROJECT_TITLE: Investigating antigen-driven clonal proliferation to target HIV-1 persistence


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Assistive Technology;Bioengineering;Neurosciences;Substance Misuse

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative In this BRAIN Initiative Optimization project, we will develop and disseminate high-density, flexible electrode arrays with thousands of low-noise, multiplexed electrodes and we will provide all of the tools, resources and training required to use this new technology in neuroscience experiments. We will enable BRAIN Initiative investigators and the broader neuroscience community to interface with the brain at a previously impossible large scale. This optimized technology will enable novel fundamental neuroscience research and next generation neuroprosthetic systems.

PI_NAMEs: FANG, HUI ;VIVENTI, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TERMS: 3-Dimensional;Amplifiers;Animal Model;Animals;biomaterial compatibility;Brain;BRAIN initiative;brain machine interface;Cerebral cortex;Chronic;Clinical;clinical application;Code;cohort;Communities;cost;cost effective;data streams;denoising;density;design;Device Designs;Devices;Educational workshop;Electrodes;Electronics;Electrophysiology (science);Encapsulated;Evaluation;Exclusion;experimental study;extracellular;Feedback;flexibility;Funding;Future;Generations;Human;Implant;improved;In Vitro;in vivo;instrumentation;irritation;manufacture;manufacturing process;Measurement;Measures;meetings;metal oxide;meter;Methods;Microelectrodes;millimeter;Modeling;Monitor;Motor;Nervous System Disorder;neural;neural circuit;neural implant;neuronal circuitry;Neurons;neuroprosthesis;Neurosciences;Neurosciences Research;neurotransmission;new technology;next generation;Noise;nonhuman primate;novel;Penetration;Performance;Polymers;Population;program dissemination;programs;Prosthesis;Real-Time Systems;Research;Research Personnel;Resolution;Resources;Rodent;Running;Sampling;scale up;Semiconductors;Shapes;Signal Transduction;Silicon;Site;Societies;Speech;statistics;Surface;System;system architecture;Techniques;Technology;Testing;Thick;Thinness;Time;tissue injury;Tissues;tool;Training;Transistors;Translating;Update;wireless

PROJECT_TITLE: Neuro-CROWN:Optimized Ultra-Flexible CMOS Electrode Arrays for 3D, Low-Noise Neural Interfaces


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE The joint Weill Cornell Medicine-New York Genome Center (WCM-NYGC) Center for Functional and Clinical Interpretation of Tumor Profiles will perform integrative analyses of coding and non-coding variants to detect and unravel the function of specific classes of mutations and assess their clinical potential.

PI_NAMEs: ELEMENTO, OLIVIER  (contact);ROBINE, NICOLAS ;STERNBERG, CORA

PROGRAM_OFFICER_NAME: YANG, LIMING

PROJECT_TERMS: Address;Algorithms;analysis pipeline;analytical tool;cancer genomics;cell type;Cells;CLIA certified;Clinical;clinical phenotype;clinically relevant;Code;Competence;Complex;Computational Biology;computer infrastructure;computerized tools;Data;data management;data portal;Development;DNA Mutational Analysis;DNA Sequence Alteration;Doctor of Philosophy;drug relapse;Drug resistance;Evolution;exome sequencing;experience;Genome;Genome Data Analysis Network;genome sequencing;genome-wide;Genomics;Germ Lines;Graph;innovation;Joints;Link;Malignant Neoplasms;Medical Oncologist;Medicine;Methods;Mutation;Neoplasm Metastasis;New York;novel;Organoids;Outcome;Pattern;Pharmaceutical Preparations;Phase;Play;precision medicine;Preparation;Primary Neoplasm;Process;Publications;Publishing;Recurrence;Research Personnel;response;Sampling;single cell sequencing;Somatic Mutation;Specific qualifier value;Testing;tool;transcriptome sequencing;transcriptomics;treatment response;tumor;tumor heterogeneity;Untranslated RNA;Variant;Visualization software;whole genome

PROJECT_TITLE: The joint WCM-NYGC Center for Functional and Clinical Interpretation of Tumor Profiles


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome

ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Little is known about the axial core, or “scaffold,” of the mitotic chromosome, and until recently its very existence was in doubt. This proposal aims to establish basic principles of scaffold organization and to develop tools for modulating scaffold assembly and function. Such tools will provide the basis for phar- macological inhibition of scaffold formation, enabling the targeting of cancer cells in a mechanistically novel manner.

PI_NAMEs: BEEL, ANDREW J. (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Affinity;Architecture;Biology;cancer cell;Cellular biology;Chemicals;Chromatin;Chromatin Loop;Chromosomal Instability;Chromosome Condensation;Chromosomes;Clinical;Communities;condensin;Cryo-electron tomography;Cryoelectron Microscopy;Development;Disease;Electron Microscope;Ensure;Environment;Equipment;equipment acquisition;Eukaryota;Event;Evolution;experience;Faculty;Filament;foot;Foundations;Funding;genetic information;Genetic Transcription;Genome;Genomic Instability;Genomics;Goals;Health;Hematologic Neoplasms;high risk;Human;Hydrogels;immune clearance;inhibitor;Institution;Interphase;invention;Investigation;Kinetochores;Knowledge acquisition;Laboratories;Literature;Malignant Neoplasms;Mass Spectrum Analysis;member;Mentors;Mentorship;Metaphase;Methods;Mitotic;Mitotic Chromosome;Molecular;Nature;Neoplastic Processes;next generation sequencing;novel;organizational structure;Pathway interactions;pharmacologic;Phase Transition;Physical condensation;Play;Positioning Attribute;Procedures;professor;Protocols documentation;Research;Research Personnel;Resolution;RNA Polymerase II;Role;scaffold;Scientist;sequencing platform;Shapes;Site;small molecule;small molecule inhibitor;Societies;Solid;Source;structural biology;Structure;success;targeted cancer therapy;tenure track;theories;Therapeutic;therapy resistant;tool;Training;Uncertainty;United States National Academy of Sciences;Work

PROJECT_TITLE: Structure and Pharmacologic Modulation of the Mitotic Chromosome's Central Axis


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Genetics;Regenerative Medicine;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Los Angeles

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project narrative One of the biggest medical issues affecting the elderly population is the progressive loss of muscle mass and strength. Recently, we discovered a new FOS/NAD/ART1-MARylation adult stem cell activation pathway that stimulates skeletal muscle repair after injury. In this project, we will explore whether this understudied pathway is disrupted in aged skeletal muscle, and whether restoring its levels can reverse the muscle dysfunction associated with the ageing process.

PI_NAMEs: ALMADA, ALBERT ERNESTO (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Address;Adenosine Diphosphate Ribose;ADP Ribose Transferases;ADP ribosylation;Adult;adult stem cell;Affect;Age;aged;Aging;aging population;aging process;Automobile Driving;Biology of Aging;Cell Cycle;Cell surface;Cleavage Under Targets and Release Using Nuclease;Clinic;cofactor;conditional knockout;Consumption;Data;Deterioration;dietary supplements;Elderly;Enzymes;Event;Exercise;extracellular;functional decline;Functional disorder;gain of function;Gene Activation;Gene Targeting;Genes;Genetic;healing;Health;Hour;Immunohistochemistry;improved;in vivo;Injury;Knockout Mice;Laboratories;LacZ Genes;Left;loss of function;Mass Spectrum Analysis;Measures;Medical;Molecular;mouse model;Mus;Muscle;muscle aging;muscle form;muscle progenitor cell;muscle repair;muscle strength;Muscular Atrophy;muscular system;Mutate;Natural regeneration;Nicotinamide adenine dinucleotide;nicotinamide-beta-riboside;novel therapeutic intervention;novel therapeutics;Oncogenes;Organ;Organoids;Osteosarcoma;overexpression;Pathway interactions;Pattern;pharmacologic;PHEMX gene;Population;Post-Translational Protein Processing;Process;programs;Proteins;Protocols documentation;regeneration potential;regenerative;regenerative tissue;repaired;Reporter;response;Signal Transduction;Site;Skeletal Muscle;skeletal preservation;Speed;stem cell function;stem cells;Supplementation;System;Testing;Therapeutic;tissue repair;Tissues;transcription factor;Transcription Factor AP-1;Trauma;virtual;Work;young adult

PROJECT_TITLE: Stem Cell Dysfunction in Aged Skeletal Muscle

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Kidney Disease;Nutrition;Obesity;Physical Activity

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitochondrial metabolism underlies poor physical endurance increasing the risk of mobility disability. The proposed project will use precise in vivo tools to study the pathophysiology of poor physical endurance in a clinical trial treating metabolic acidosis among persons living with chronic kidney disease.

PI_NAMEs: ROSHANRAVAN, BABACK  (contact)

PROJECT_TERMS: Affect;Alkalies;Animal Model;Bicarbonates;Binding;Biology;Carbohydrates;Cessation of life;Chronic Kidney Failure;Clinical Trials;Closure by clamp;Cross-Over Trials;Development;disability;Dose;efficacy testing;Ergometry;Exercise Tolerance;Fatigue;Fatty acid glycerol esters;Functional disorder;functional independence;Future;Gastrointestinal tract structure;Glucose Clamp;Health;Heart failure;high risk;Human;Hydrogen Chloride;Hyperinsulinism;Hypertension;Impairment;improved;in vivo;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;Intervention;Investigation;K-Series Research Career Programs;lifestyle intervention;Link;lipid metabolism;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Maintenance;Measures;Metabolic;Metabolic acidosis;Metabolism;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Mobility disability;Morbidity - disease rate;Muscle;Muscle Contraction;muscle metabolism;Muscle Mitochondria;muscle physiology;Muscular Atrophy;Nephrology;nutrition;Obesity;older adult;Participant;Patient Self-Report;Patients;Peripheral;Persons;pharmacologic;Physical Endurance;Physical Function;Placebo Control;Placebos;Polymers;Population;Proteins;Quality of life;Questionnaires;Randomized;randomized trial;randomized, clinical trials;Risk;Serum;Severities;Skeletal Muscle;skeletal muscle wasting;Sodium;Sodium Bicarbonate;Standardization;Testing;therapeutic target;Time;tool;Translating;treatment duration;trial design;Walking;wasting;Work

PROJECT_TITLE: Impact of metabolic acidosis on muscle mitochondrial energetics, metabolic health and physical endurance in persons with chronic kidney disease


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Project Narrative In this proposal, we bring together a unified team with a strong track record of developing secure and scalable software systems to support flagship scientific initiatives, such as the All of Us Research Program, the Human Cell Atlas, and the first phase of the AnVIL itself. Our group will leverage these experiences, and the software developed for them, to create an ecosystem of tools, applications, and services that will continue to serve the needs of the NHGRI community in this second phase of the AnVIL. Importantly, our approach prioritizes the continued creation and evolution of a federated data ecosystem, one in which the AnVIL will continue to interoperate with other key NIH data science initiatives.

PI_NAMEs: CARROLL, ROBERT J;LAWSON, JONATHAN  (contact);PATEN, BENEDICT

PROGRAM_OFFICER_NAME: WELLINGTON, CHRISTOPHER

PROJECT_TERMS: Acceleration;Adoption;All of Us Research Program;analytical tool;Atlases;Automobile Driving;base;Catalogs;Cells;Clinical;Clinical Data;Clinical Services;cloud based;cloud platform;cohort;Communities;Computer software;Cost Control;Data;data ecosystem;Data Engineering;data ingestion;data management;data modeling;data platform;data portal;Data Science;Data Set;data sharing;data standards;Dedications;diverse data;Documentation;Ecosystem;Engineering;Environment;Evolution;experience;federated data;Genetic Diseases;genetic variant;genomic data;Genomics;Goals;Growth;Health;Human;improved;Individual;Infrastructure;Ingestion;International;interoperability;Joints;large datasets;Maps;meetings;National Human Genome Research Institute;operation;outreach;Phase;prevent;Process;Protocols documentation;Research;Research Personnel;Resources;Secure;Security;service utilization;Services;software development;Software Engineering;software infrastructure;software systems;success;support tools;System;Tail;tool;Training;United States National Institutes of Health;Vision;web services

PROJECT_TITLE: Expanding the AnVIL Data Ecosystem


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Assistive Technology;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Lung;Orphan Drug;Pneumonia;Pneumonia and Influenza;Rare Diseases;Rehabilitation

ORG_CITY: Redwood City

ORG_NAME: TRELLIS BIOSCIENCE, INC.

PHR: Narrative The CDC estimates that 65-80% of clinically significant bacterial infections are biofilm-mediated, including: infected spine and joint implants, osteomyelitis (bone infections), lung infections associated with cystic fibrosis and Chronic Obstructive Pulmonary Disease (COPD), infective endocarditis, indwelling catheter infections, and chronic non-healing wounds. Among ICU admissions, 30-50% carry reservoirs of bacteria in the nasopharynx (determined by swabs). Ventilator associated pneumonia (VAP) adds $1 billion to the cost of ICU care annually in the US. Inhaled delivery of TRL1068 can be readily included in the treatment by plugging the nebulizer device into the ventilator. From a regulatory perspective, treatment of hospital acquired pneumonia provides high potential benefit at minimal risk and the high incidence allows for efficient clinical trials. Exacerbation of COPD by bacterial infection is a more complex indication, but one which affects a large population for whom inhaled delivery (hand held nebulizer) offers a substantially more convenient treatment option, addressing a potential market of over $5 billion. Dual use for biodefense against naturally emerging or maliciously engineered respiratory pathogens will also be facilitated by development of our inhaled delivery formulation.

PI_NAMEs: KAUVAR, LAWRENCE MICHAEL (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;Adhesions;Admission activity;Adult;Affect;Animal Model;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Antibodies;B-Lymphocytes;Bacteria;Bacterial Infections;Bacterial Pneumonia;bactericide;biodefense;Caring;Catheters;Chronic;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;Clinical Data;clinical development;Clinical Research;clinical trial implementation;Clinical Trials;clinically significant;Combating Antibiotic Resistant Bacteria;Complex;Consultations;Contractor;cost;Cystic Fibrosis;Data;detection limit;Development;Devices;Documentation;Dose;Drug Kinetics;Engineering;Ethical Review;Excision;experience;Failure;Feedback;Formulation;Funding;Government;Grant;Hand;Health Personnel;Human;human monoclonal antibodies;Human Resources;Implant;Incidence;Indwelling Catheter;Infection;Infective endocarditis;Influenza Therapeutic;Inhalation;innovation;Institutional Review Boards;Intravenous;Joints;lead candidate;Liquid substance;Lung infections;Marketing;Mediating;Medical;Methods;Microbial Biofilms;minimal risk;Monoclonal Antibodies;Nasopharynx;National Institute of Allergy and Infectious Disease;Nebraska;Nebulizer;non-healing wounds;Nosocomial pneumonia;operation;Operative Surgical Procedures;Osteomyelitis;Particulate Matter;Patients;Penetration;Periprosthetic joint infection;Phase;Phase I Clinical Trials;phase I trial;phase II trial;Population;pre-clinical;Preparation;programs;Prosthesis;Protocols documentation;Reporting;respiratory pathogen;Respiratory System;Ringer's solution;Rodent Model;Safety;safety assessment;Services;Site;Small Business Innovation Research Grant;Sonication;standard of care;Standardization;Swab;Techniques;Therapeutic;Therapeutic Agents;Therapeutic antibodies;Therapeutic Monoclonal Antibodies;Tissues;Toxicology;treatment duration;trial planning;U-Series Cooperative Agreements;United States National Institutes of Health;Vendor;Ventilator;ventilator-associated pneumonia;Vertebral column;volunteer;Work;Writing

PROJECT_TITLE: Bacterial Pneumonia Therapeutic Antibody Safety Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 AWA-M (M2)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Genetics;HIV/AIDS;Human Genome;Lung;Microbiome

PHR: PROJECT NARRATIVE (STATEMENT OF PUBLIC HEALTH RELEVANCE) Chronic obstructive pulmonary disease (COPD) is the third most common cause of death worldwide and people with HIV are at increased risk of developing COPD. I am a pulmonologist with expertise in global health research and microbiome science and here I propose a project to use multi-omics data to better understand how lung function loss and COPD develop in people with HIV in low- and middle-income countries, where over 80% of COPD deaths occur. This information will help us determine who is at highest risk for COPD and identify new therapeutic targets for COPD in people with HIV.

PI_NAMEs: PATEL, SWETA MAHESH (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Address;Adult;Affect;Africa South of the Sahara;Automobile Driving;biobank;Biological Markers;Botswana;Cause of Death;Cessation of life;Chronic;Chronic Obstructive Pulmonary Disease;Clinical;cohort;Core Facility;Coupled;cytokine;Data;Disease Progression;DNA sequencing;experience;Face;Feces;Future;global health;high risk;HIV;Home;host microbiome;host-microbe interactions;Impairment;Inflammation;Inflammatory;Link;Longitudinal cohort;loss of function;low and middle-income countries;Lung;Machine Learning;Mass Spectrum Analysis;Measures;metabolomics;metagenomic sequencing;microbial community;microbiome;microbiome alteration;microbiome analysis;microbiome composition;microbiome research;Morbidity - disease rate;mortality;Multiomic Data;multiple omics;National Heart, Lung, and Blood Institute;new therapeutic target;Oral cavity;Pathway interactions;Patients;Persons;Population;predictive modeling;public health relevance;pulmonary function;Research;Research Infrastructure;Respiratory Signs and Symptoms;Risk;Risk Factors;risk stratification;Saliva;Sampling;Severity of illness;Shotguns;Specimen;Spirometry;Sputum;Statistical Methods;systemic inflammatory response;transcriptome sequencing;transcriptomics;Universities

PROJECT_TITLE: Harnessing multi-omics to identify host-microbiome interactions driving HIV-associated chronic obstructive pulmonary disease in low and middle income countries.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-P (55)]


NIH_SPENDING_CATS: Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: GROTON

ORG_NAME: ONCOARENDI THERAPEUTICS, LLC

PHR: Narrative Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal disease of the lung, which is estimated to affect 5 million people worldwide, and which only has an average survival of 3-5 years after diagnosis We are conducting research, including the use of disease-relevant animal models, on a new type of potential oral medicine, a MRFT pathway modulator, for IPF that has the potential to provide superior medical benefit and improved safety compared to current treatments, and will increase survival and the quality of life for IPF patients. The results from the studies outlined in this application will be an important step towards the clinical testing of an oral MRFT pathway modulator compound in patients with the deadly disease of IPF.

PI_NAMEs: GOLEBIOWSKI, ADAM  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Actins;Address;Adult;Affect;analog;Animal Model;Attenuated;Binding Proteins;Biological;Biological Assay;Cardiac;Cellular Assay;Characteristics;Chemicals;Chronic;Clinical;clinical development;clinical effect;Collagen Type I;connective tissue growth factor;Diagnosis;Disease;Dose;Drug Kinetics;Etiology;Extracellular Matrix Proteins;FDA approved;Fibroblasts;Fibrosis;fibrotic lung disease;Foundations;Future;Genes;Goals;Histologic;Human;idiopathic pulmonary fibrosis;improved;In Vitro;in vivo;indium-bleomycin;inhibitor;innovation;Ion Channel;Lead;lead optimization;lead series;Link;Literature;Liver Microsomes;Luciferases;Lung;Lung Diseases;Measures;Mediator;Medical;Medicine;Metabolic;meter;Modeling;Molecular Target;Morbidity - disease rate;mortality;Mus;myocardin;Myofibroblast;nintedanib;novel;novel therapeutic intervention;Oral;Oral Administration;Oral Medicine;Pathway interactions;Patients;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacology;pharmacophore;Phase;Pirfenidone;Plasma;Plasma Proteins;Potassium Channel;Process;prophylactic;Pulmonary Fibrosis;Quality of life;Reporting;Research;research clinical testing;response;Rodent;Rodent Model;Safety;screening;Small Business Innovation Research Grant;small molecule;Smooth Muscle;Solubility;standard of care;Structure-Activity Relationship;T-Lymphocyte;Testing;Therapeutic;transcription factor;Transfection

PROJECT_TITLE: Myocardin-related transcription factor (MRTF) pathway modulators as a novel, disease-modifying oral medicine for idiopathic pulmonary fibrosis (IPF)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (11)]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Hematology;Orphan Drug;Rare Diseases

ORG_CITY: RALEIGH

ORG_NAME: GENEVENTIV THERAPEUTICS, INC.

PHR: Narrative Current treatment of hemophilia by protein replacement therapy is constrained by the short half-life of the clotting factors, requiring repeated infusions at relatively large doses. Approximately 20–30% of patients with hemophilia A and 5% of patients with hemophilia B develop antibodies against the infused factors (termed inhibitors) after protein replacement therapy, which remains the single most important obstacle to managing hemophilia. In patients with inhibitors, the administration of clotting factors is ineffective, and poor control of hemorrhagic episodes increases complications associated with the disease. GeneVentiv is directly addressing this critical unmet need through the development of GENV-HEM, the first universal gene therapy for all hemophilias and the first designed to treat inhibitor patients.

PI_NAMEs: MARGARITIS, PARIS  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Address;Animal Model;Antibodies;Biological Assay;Blood Coagulation Disorders;Blood Coagulation Factor;Bypass;candidate identification;canine model;Canis familiaris;Coagulation Process;cofactor;commercialization;Data;design;Development;Disease;Dose;efficacy evaluation;Engineering;enzyme replacement therapy;Equipment;Event;F8 gene;Factor IX;Factor IXa;Factor VIII;Factor X;Factor Xa;gene therapy;Generations;Goals;Half-Life;Hemophilia A;Hemophilia B;Hemorrhage;Hemostatic Agents;Hemostatic function;Human;improved;Infusion procedures;Inherited;inhibitor;Injury;innovative technologies;Isoantibodies;large scale production;lead candidate;lead optimization;Liver;Macaca mulatta;manufacture;Measures;method development;Methods;mouse model;nonhuman primate;novel;Outcome;Pathway interactions;Patients;Pharmacology and Toxicology;Phase;Phase I Clinical Trials;Phenotype;Plasma;Preparation;Process;promoter;Proteins;prothrombinase complex;Quality Control;response;response to injury;Safety;Subcutaneous Injections;Technology;technology platform;Testing;Therapeutic;Thrombin;Thrombosis;Toxicology;vector;Work

PROJECT_TITLE: Development of a universal gene therapy for hemophilia A or B with or without inhibitors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (11)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Services;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: MIAMI

ORG_NAME: OUR RELATIONSHIP LLC

ORG_STATE: FL

PHR: PROJECT NARRATIVE Problems in romantic relationships increase the likelihood and severity of substance misuse, make recovery services less effective, and increase the subsequent risk of relapse. However, substance use recovery services typically omit a focus on romantic relationships. This application adapts the effective OurRelationship program to create Our-S, a brief digital program designed to be an adjunctive intervention for individuals recovering from substance misuse and their romantic partners.

PI_NAMEs: SANSBURY, KELLY BROCK (contact)

PROGRAM_OFFICER_NAME: FLOOD, MORRIS

PROJECT_TERMS: Address;Administrator;Adoption;Affect;Alcohol abuse;Android;animation;Award;Behavioral;behavioral health;Capital;Caregivers;Case Manager;Certification;Child;Clinic;Collaborations;commercialization;Communities;Conflict (Psychology);Contracts;cost effective;Couples;Couples Therapy;design;Development;digital;digital health;Distress;Drug usage;effective therapy;Effectiveness;evidence base;experience;Family;family support;Feedback;Focus Groups;follow-up;Funding;Gender;Glean;Grant;Group Structure;Group Therapy;Happiness;Health Technology;Hour;improved;improved outcome;Individual;Industry;Intervention;Interview;Marketing;Measures;Medicaid;Military Personnel;National Institute of Drug Abuse;neglect;Outcome;outreach;Personal Satisfaction;Phase;physical conditioning;Population;Prevention;Process;Productivity;programs;Provider;Randomized;Recovery;recovery services;relapse risk;Reporting;response;return to use;Self Direction;Series;service organization;service providers;Services;services as usual;Severities;Small Business Innovation Research Grant;social;social engagement;social health determinants;social skills;substance misuse;substance use;Surveys;Testing;tool;Training;Trauma;treatment services;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;uptake;user-friendly;Work

PROJECT_TITLE: OurRelationship-S: A Digital Relationship-Strengthening Program for Couples Experiencing Substance Misuse.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (10)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE This training program requests continued funding for 5 graduate students and 2 postdoctoral fellows in a multi- disciplinary but highly integrated Molecular Microbiology Training Program (MMTP). Trainees who complete this program are expected to be able to apply state-of-the-art molecular approaches towards important problems in the microbiological sciences and for the improvement of preventive and/or therapeutic intervention strategies for various infectious diseases.

PI_NAMEs: PFEIFFER, JULIE K (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Grant;Microbiology;Molecular;Training

PROJECT_TITLE: Molecular Microbiology Training Grant

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: MALVERN

ORG_NAME: VENATORX PHARMACEUTICALS, INC.

ORG_STATE: PA

PHR: PROJECT NARRATIVE The penicillin-binding-protein-targeting β-lactams are a mainstay therapeutic option for infections caused by gram negative bacteria including Acinetobacter baumannii, but efficacy of these agents is threatened by the continued evolution and expansion of β-lactamases (e.g., NDM) that contribute to epidemiological expansion of carbapenem-resistant Acinetobacter baumannii (CRAB) infections. This application focuses on the advancement of non-β-lactam cyclic boronate PBP inhibitors (boro-PBPi) for intravenous therapy of CRAB infections, from lead optimization to non-GLP profiling for nomination of a preclinical candidate(s), without siderophore conjugation that facilitates uptake by specific transporter systems. The boro-PBPi product would avoid class-specific resistance to both β-lactams and siderophore-conjugated antibiotics (e.g., cefiderocol), and reset the resistance timeline, thus providing a powerful new treatment option against the most problematic MDR pathogens in the hospital setting.

PI_NAMEs: UEHARA, TSUYOSHI  (contact)

PROJECT_TERMS: Acinetobacter;Acinetobacter baumannii;Address;Affinity;Animals;Anti-Bacterial Agents;Antibiotics;Applications Grants;bactericide;beta-Lactam Resistance;beta-Lactamase;beta-Lactams;Biological;carbapenem resistance;Carbapenem-resistant Acinetobacter;carbapenemase;Carbapenems;Cell Wall;Centers for Disease Control and Prevention (U.S.);Cephalosporins;Chemicals;Chemistry;Classification;Clinical;Collection;Complex;design;Development;drug development;drug metabolism;efficacy study;Epidemiology;Equus caballus;Evaluation;Evolution;Exhibits;Failure;FDA approved;Female;Fiber;Funding;Future;Genes;genotoxicity;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Grant;high risk;Hospitalization;Hospitals;human pathogen;improved;In Vitro;in vivo;Infection;inhibitor;innovation;Intravenous;Lactams;Lead;lead optimization;lead series;Lung infections;male;Maps;Mediating;Medical;Meropenem;Modeling;Morbidity - disease rate;mortality;multi-drug resistant pathogen;Mus;Mutation;New Agents;novel;novel antibiotic class;novel therapeutics;pathogen;pathogenic bacteria;Pathway interactions;Patients;Penicillin-Binding Proteins;Periodicity;Pharmaceutical Chemistry;pharmacokinetics and pharmacodynamics;Phase;pre-clinical;Preparation;Production;programs;Property;prototype;Rattus;Research;Resistance;Resistance development;resistance frequency;resistance mechanism;Risk;Route;Safety;scale up;Series;Siderophores;Small Business Innovation Research Grant;Solubility;Structure;Sulbactam;sultamicillin;System;targeted agent;Therapeutic;Thigh structure;timeline;Toxicology;uptake;VDAC1 gene;ventilator-associated pneumonia;World Health Organization

PROJECT_TITLE: Novel Cyclic Boronate Cell Wall Inhibitors Targeting Carbapenem-Resistant Acinetobacter baumannii

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-F (12)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY

PHR: Narrative  The proposal addresses two challenges to Ending the HIV Epidemic (EHE): increasing comorbidities, coinfections, and complications in PWH and widening disparities in HIV care outcomes. Understanding any lasting impacts of the COVID-19 pandemic on the care of people with HIV and structural issues at the root of HIV and other healthcare disparities is crucial for the success of EHE initiatives. We expect this K01 to generate landmark publications and rich preliminary data for an R-series proposal from a new investigator to expand research into support and care for PWH and the short- and longer-term impacts of the SARS-CoV-2 and future pandemics on EHE.

PI_NAMEs: ROBERTSON , MCKAYLEE   (contact)

PROGRAM_OFFICER_NAME: ROE, JOANAD'ARC C

PROJECT_TERMS: 2019-nCoV;access disparities;Address;Adult;advanced disease;Anti-viral Agents;Area;Biostatistical Methods;Cardiovascular system;care outcomes;career;Caring;Clinical;clinical risk;Clinical Treatment;co-infection;cohort;Communicable Diseases;Communities;comorbidity;Complex;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 vaccine;Data;Data Reporting;Data Sources;design;Development;disability;Disease;Disparity;disparity elimination;Economics;Electronic Health Record;Environment;Epidemic;epidemiologic data;Epidemiology;Equity;Event;experience;exposure pathway;Funding;future pandemic;Goals;health care disparity;health disparity;health record;Healthcare Systems;high risk;HIV;Hospitalization;Immunocompromised Host;improved;Incidence;innovation;insight;Intervention;Knowledge;Liver diseases;longitudinal design;Measurement;Mediation;Mediator;Mental Depression;Methodology;Methods;Modeling;Modernization;multilevel analysis;Natural History;next generation;novel;online community;Outcome;pandemic disease;pandemic preparedness;Pathway interactions;Patient Self-Report;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Population;post-COVID conditions;Prospective cohort;Publications;racial disparity;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;Role;SARS-CoV-2 antiviral;SARS-CoV-2 infection;Series;severe COVID-19;skills;social;social determinants;social factors;social health determinants;Structural Models;success;Symptoms;Time;Training;Treatment Factor;United States National Institutes of Health;Viral;Viral Load result

PROJECT_TITLE: Examining the Interplay of COVID-19 and HIV: Impacts on HIV Care, Disparities, and Long-Term Outcomes

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Back Pain;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Substance Misuse;Traumatic Head and Spine Injury

ORG_CITY: Davis

ORG_NAME: EICOSIS, LLC

PHR: Narrative Inhibiting the soluble epoxide hydrolase enzyme offers a potent, first-in-class analgesic strategy to treat chronic neuropathic pain conditions while replacing and dose reducing the use of opioids. EicOsis is moving the IND candidate EC5026 rapidly to market as a safe, effective and non-addictive strategy to treat chronic pain. Preclinical results with EC5026 show broad efficacy in neuropathic models and preparation for an IND filing is underway, here we continue the drive to clinical trials in humans.

PI_NAMEs: CORTES-PUCH, IRENE  (contact);HAMMOCK, BRUCE D

PROGRAM_OFFICER_NAME: REICHEL, CARMELA MARIE

PROJECT_TERMS: Accidents;addiction;Analgesics;Attenuated;behavioral outcome;Biochemical;Biological;Biological Markers;Canis familiaris;capsule;Cessation of life;Chemicals;chronic neuropathic pain;chronic pain management;chronic pain relief;chronic painful condition;Clinical;clinical development;Clinical Trials;Combined Modality Therapy;comparative efficacy;Cyclic GMP;Data;design;Development;Dose;Drug Kinetics;efficacy evaluation;efficacy study;efficacy testing;efficacy trial;Ensure;Enzymes;Epoxide hydrolase;Fasting;Fatty Acids;Formulation;Foundations;Goals;Human;human subject;Individual;inflammatory pain;inhibitor;lead candidate;Lipids;Low Back Pain;manufacture;Marketing;Medicine;meetings;Metabolism;Modeling;Monitor;Morbidity - disease rate;mortality;multimodality;National Institute of Neurological Disorders and Stroke;Neuropathy;Non-Steroidal Anti-Inflammatory Agents;novel;Opioid;Opioid Analgesics;opioid overdose;opioid sparing;opioid use;opioid use disorder;Pain;Pain management;pain model;pain relief;painful neuropathy;patient population;Patients;Pharmacologic Substance;Phase;phase 2 designs;Phase Ia Trial;Polyunsaturated Fatty Acids;Positioning Attribute;pre-clinical;preclinical efficacy;preclinical safety;preclinical study;Preparation;prescription opioid;prevent;programs;Rattus;Refractory;Rodent;Safety;safety assessment;safety study;safety testing;Sampling;side effect;small molecule inhibitor;Spinal cord injury;Spinal cord injury patients;Structure;Testing;Therapeutic Equivalency;Treatment Efficacy;United States;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Development of a Soluble Epoxide Hydrolase Inhibitor to Spare or Replace Opioid Analgesics


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative A key role of the olfactory system is to guide animals towards things they need and away from things they ought to avoid. Using fMRI in humans, we will probe the neural formation of an olfactory cognitive map that (1) guides such odor-based navigation and (2) facilitates sensory prediction to aid adaptive decision-making.

PI_NAMEs: GOTTFRIED, JAY A (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Adaptive Behaviors;Air;Animals;Association Learning;Behavior;behavior test;Behavioral;Biological Assay;Brain;Categories;cell type;Cells;Characteristics;Code;Cognitive;Cues;Data;Decision Making;design;Distal;Elements;Ensure;entorhinal cortex;Environment;experimental study;flexibility;Floor;follow-up;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Goals;high risk;Hippocampal Formation;hippocampal subregions;Hippocampus;Human;human subject;insight;interdisciplinary approach;Knowledge;Learning;Location;Mammals;Maps;Memory;Modeling;Movement;Nature;neural;Neurosciences Research;Odors;Olfactory Pathways;Oral cavity;parent grant;Participant;Pathway interactions;Pattern;piriform cortex;Play;Poaceae;Positioning Attribute;Predisposition;Prefrontal Cortex;programs;Property;Psychophysics;receptor;Research;Resolution;response;Rewards;Rodent;Role;Route;Sensory;Sleep;Smell Perception;Space Perception;Stimulus;Testing;virtual;virtual reality;Visual;Volatilization;way finding;Work

PROJECT_TITLE: Behavioral and Neural Substrates of Odor-Guided Navigation in the Human Brain

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: New York

ORG_NAME: SPARK NEURO INC.

PHR: PROJECT NARRATIVE Existing techniques for evaluating cognitive status and diagnosing Alzheimer’s disease (AD) do not meet the current clinical need. To address this problem, SPARK Neuro is developing the first-of-its-kind SPARK Scan technology, a standardized, objective, non-invasive, and cost-effective diagnostic tool. This cloud-based, neuroanalytic platform will constitute the first in-office, EEG-based diagnostic aid specifically developed for identifying AD and staging cognitive status, establishing the clinical context for diagnosing biomarker-defined AD and connecting patients to treatments for this devastating disease.

PI_NAMEs: LUCERO, CHE  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Accounting;Address;Affect;aging population;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer’s disease biomarker;Biological Markers;blood-based biomarker;candidate identification;Clinical;Clinical Research;clinical research site;cloud based;Cognitive;commercialization;Computer software;cost;cost effective;Country;cyber security;Data;Data Collection;Dementia;design;Diagnosis;Diagnostic;diagnostic tool;Disease;Disease Progression;Documentation;Electroencephalography;Evaluable Disease;Guidelines;hazard;Health Care Costs;high risk;Impaired cognition;Infrastructure;Joints;Machine Learning;Modeling;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;neural;novel;Older Population;Output;Pathologic;Pathology;Patients;Penetration;Performance;Persons;Phase;Physicians;Positioning Attribute;Preparation;primary endpoint;Proteins;recruit;Reporting;Rest;Risk;Scanning;Security;Small Business Innovation Research Grant;Specific qualifier value;Specificity;Staging;Standardization;statistics;Techniques;Technology;Testing;Training;United States;Update;Validation;verification and validation

PROJECT_TITLE: Validation of a novel EEG-based neurodiagnostic platform for assessing cognitive impairment and Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-C (10)]


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Bacterial Vaginosis is mediated by a non-optimal vaginal microbiome, is characterized by vaginal inflammation, and increases HIV risk by mechanisms that are not completely understood. This project aims to elucidate the role that macrophages play in increasing HIV risk in women who have BV, using multi-omic analyses and machine learning. The knowledge obtained from this proposal will contribute to mechanistic understanding of BV-mediated HIV transmission, which will provide insight necessary to improve strategies for vaginal health and HIV prevention.

PI_NAMEs: PARKER, IVANA  (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Age;AIDS prevention;Bacterial Vaginosis;Biological Process;Cells;citizen science;Clinical Research;Complex;Computer Analysis;Couples;Data;empowerment;Epidemic;Epigenetic Process;Exposure to;Ghana;Health;HIV;HIV Infections;HIV risk;Immune;immune cell infiltrate;Immunity;improved;Inflammation;Inflammatory;inflammatory marker;innovation;insight;Intervention;Knowledge;Link;Machine Learning;Macrophage;Macrophage Activation;Mediating;Metabolic;metabolomics;Metagenomics;microbial;microbial composition;microbiome;microbiome research;Modeling;multiple omics;novel;Participant;permissiveness;Phenotype;Play;Prevalence;Probiotics;Proteome;Proteomics;recruit;Recurrence;reproductive;Risk;Role;Science;South Africa;Symptoms;Testing;Tissues;tool;Training;transmission process;Vagina;vaginal fluid;Vaginal Itching;vaginal microbiome;Woman;Women's cohort

PROJECT_TITLE: The Role of the Macrophage in Bacterial Vaginosis Mediated HIV Risk