ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE Magnetic resonance imaging (MRI) is a powerful technique for assessing the human brain in vivo, but head motion continues to be a substantial problem for neuroimaging, especially in patients who are agitated or confused, and in children and infants. The proposed project will develop an MRI-navigator based motion correction technique to eliminate through-plane slice-alignment errors and in-plane movements in 2- dimensional structural (T2-weighted) MRI, and validate the new technique in healthy cdontrol subjects. Successful completion of the proposed development will improve the robustness of MRI from those with head movements and promises to improve the quality of 2D brain MRI scans both in the clinical and research settings.

PI_NAMEs: ERNST, THOMAS M (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Address;Affect;Agitation;Anatomy;Attenuated;Brain;brain magnetic resonance imaging;Child;Clinical;cohort;Compensation;Complex;Confusion;Data;Dedications;Dementia;design;Development;diagnostic accuracy;Economics;Functional Magnetic Resonance Imaging;Future;Goals;Head;Head Movements;Human;Image;improved;in vivo;Individual;Infant;Instruction;Magnetic Resonance Imaging;Measures;Methods;Modeling;Morphologic artifacts;Motion;motion sensitivity;Movement;Movement Disorders;MRI Scans;neuroimaging;novel;Optics;Participant;Patients;Physiologic pulse;Physiology;Positioning Attribute;prospective;reconstruction;Recording of previous events;Research;Research Subjects;Resolution;Rotation;Sampling;Scanning;Signal Transduction;Slice;Source;Structure;Techniques;temporal measurement;Testing;Time;Training;Translations;two-dimensional;Visual;Work

PROJECT_TITLE: Elimination of slice alignment errors in 2-dimensional structural MRI

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Dementia;Genetics;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Telehealth

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Innovative methods to improve timely and accurate detection of Alzheimer's disease and related dementias are urgently needed for optimizing dementia care. We propose to leverage passively collected smartphone data capturing smartphone interactions (via screen use and battery data) and everyday activity (via accelerometer and GPS data), and evaluate their utility to detect neurobehavioral impairment in frontotemporal dementia and Alzheimer's disease. We will further validate their clinical relevance by testing baseline and longitudinal associations with gold-standard in-person cognitive tests and biomarkers of neurodegeneration.

PI_NAMEs: PAOLILLO, EMILY  (contact)

PROGRAM_OFFICER_NAME: PLUDE, DANA JEFFREY

PROJECT_TERMS: Accelerometer;actigraphy;Address;Adult;Age-associated memory impairment;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease related dementia;Assessment tool;autosome;Behavior;Behavioral;Big Data;Big Data Methods;biobehavior;Biological Markers;CCL4 gene;Cellular Phone;Clinic;Clinical;clinically relevant;Cognition;Cognitive;cognitive change;cognitive testing;cohort;Data;Data Analyses;Data Collection;Data Science;Dementia;dementia care;Detection;Development;digital;digital assessment;digital data;digital health;digital phenotyping;Disease;Drainage procedure;Early Diagnosis;Environment;Equity;Evaluation;follow-up;Frequencies;Frontotemporal Dementia;Functional impairment;Future;Goals;health data;high dimensionality;Home;Human;Impairment;Improve Access;improved;Individual;innovation;K-Series Research Career Programs;Knowledge;Leadership;Life;Light;Machine Learning;machine learning algorithm;Measurement;Measures;Memory;Mentors;Mentorship;Methodology;Methods;mobile application;mobile computing;Modeling;Monitor;multidisciplinary;multimodality;Mutation;mutation carrier;Nerve Degeneration;neurobehavior;neurobehavioral;Neurobehavioral Manifestations;Neurodegenerative Disorders;neurofilament;Neurologic;Neuropsychology;novel;Outcome;Pathologic;Patients;Persons;Phenotype;phenotypic data;Physical Function;Plasma;Population;Prevention;prognostication;prospective;remote monitoring;remote sensor;Research Design;Research Personnel;sensor technology;skills;Social Functioning;Specificity;standard measure;tau-1;Techniques;Technology;Testing;theories;Time;tool;Training;Translating;treatment trial;tv watching;Underrepresented Populations;Validation;Visit;wearable device;Work

PROJECT_TITLE: Passive digital phenotyping for capturing real-world neurobehavior in neurodegenerative disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Disability Research;Neurodegenerative;Neurosciences;Rare Diseases;Rehabilitation;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Ischemic stroke causes long-term disability, stroke-related co-morbidities, and accelerated cognitive decline which negatively impact quality of life in a sex-specific manner. The proposed studies will investigate the secondary injury mechanisms underlying disease progression during the chronic phase of stroke in older males and females to reveal the chronicity of events leading to a higher risk of vascular dementia. The determination of brain injury-induced cellular senescence as a causal driver of long-term neurological impairment will dramatically improve our understanding of recovery after stroke, provide means for improving diagnostics, and open new and wider windows of delayed treatment for stroke survivors.

PI_NAMEs: RITZEL, RODNEY  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Acceleration;Acute;Adult;Age;age acceleration;Age Months;age related;aged;Aging;aging biomarker;aging brain;Alzheimer's Disease;Amyloid;Amyloid deposition;Amyloidosis;Animal Model;arm;Attenuated;Automobile Driving;behavior test;Behavioral;beta-Galactosidase;Biological;Biological Aging;Biological Markers;Blood Vessels;Brain;Brain Diseases;Brain hemorrhage;Brain Injuries;Caring;Cause of Death;Cell Aging;cell type;Cerebral Amyloid Angiopathy;Cerebral small vessel disease;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrum;Chronic;Chronic Phase;Clinical Trials;Cognitive;Cognitive deficits;cognitive function;cognitive testing;cohort;combinatorial;comorbidity;conditioned fear;Cytology;Dasatinib;Data;Dementia;Deterioration;Diagnostic;Disease;disease phenotype;Disease Progression;Drug Targeting;Enzyme-Linked Immunosorbent Assay;Event;Exhibits;experience;experimental study;Female;Functional disorder;functional outcomes;glial activation;Gliosis;Gonadal Steroid Hormones;healthy aging;Hemorrhage;high risk;Impaired cognition;Impairment;improved;Inflammation;Inflammatory;Injury;innovation;Ischemia;ischemic injury;Ischemic Stroke;Lacunar Infarctions;Laser Speckle Imaging;life span;Link;Long term disability;long term recovery;long-term sequelae;Magnetic Resonance Imaging;male;Maps;Measures;men;Menopause;Microglia;Microvascular Dysfunction;middle age;Middle Cerebral Artery Occlusion;mild cognitive impairment;Modeling;motor deficit;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;Neurologic;Neurological outcome;neuropathology;neuroprotection;novel;object recognition;old mice;older adult;older women;Outcome;Ovarian hormone;Pathogenicity;Pathologic;Pathology;Patients;Pharmaceutical Preparations;post stroke;post stroke cognitive impairment;Postmenopause;premature;Prevalence;prevent;progressive neurodegeneration;Property;Quality of life;Quercetin;Radial;Recovery;Recovery of Function;Reporting;reproductive senescence;Research;Role;Running;Secondary Lesion;Secondary to;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Senotherapeutic;sex;Sex Differences;sham surgery;single-cell RNA sequencing;Site;Stroke;stroke patient;stroke survivor;stroke therapy;Structure;Survival Rate;Survivors;Swab;Testing;Thrombectomy;Time;treatment strategy;United States;Vagina;Vascular Dementia;white matter;white matter injury;Woman;women versus men;Women's mortality

PROJECT_TITLE: Cellular senescence as a potential sex-specific driver of small vessel disease and post-stroke cognitive impairment in late adulthood

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-B (55)]


ADMINISTERING_IC: DK

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Digestive Diseases;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: PROJECT NARRATIVE Mechanisms driving weight loss after bariatric surgery remain unclear, though rapid delivery of nutrients mimics the augmented gut peptide response of bariatric surgery even in non-surgical patients. This career development award combines enteral nutrient infusion and tolerance testing with functional magnetic resonance imaging (fMRI) to (1) test the hypothesis that rapid nutrient delivery is associated with increased gut peptide and brain fMRI responses, (2) test the hypothesis that Roux-en-Y gastric bypass is associated with faster nutrient absorption compared to sleeve gastrectomy, and (3) identify brain regions rapidly responsive to enterally delivered nutrients.

PI_NAMEs: ALBAUGH, VANCE L (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: absorption;Affect;Amino Acids;analog;Anatomy;Automobile Driving;bariatric surgery;Bariatrics;Behavior;Body Weight decreased;Brain;Brain imaging;Brain region;career development;Cells;Central Nervous System;Cholecystokinin;Chronic;Clinical;Coupling;Data;Detection;detection of nutrient;Development Plans;Duodenum;Eating;Endocrine;Energy Intake;Enteral;Enteral Feeding;Environment;fasting glucose;feeding;Feeding behaviors;Food;Food Preferences;Functional Magnetic Resonance Imaging;Future;Ganglia;Gastrectomy;Gastric Bypass;gastrointestinal;Gastrointestinal Motility;ghrelin;glucagon-like peptide 1;Glucose;Goals;gut-brain axis;Human;human subject;Infusion procedures;innovation;Intestinal Mucosa;Intestines;K-Series Research Career Programs;Knowledge;Liquid substance;Measurement;Measures;Mediating;Mentors;Modeling;neural;neurotransmission;novel therapeutic intervention;Nutrient;nutrient absorption;obese patients;Obesity;Obesity Epidemic;obesity treatment;operation;Operative Surgical Procedures;Oral;Pathway interactions;patient oriented research;Patients;Peptides;Perception;Peripheral;Pharmaceutical Preparations;Physiology;Positioning Attribute;Postoperative Period;pre-clinical;Pre-Clinical Model;Process;Research;response;Rewards;Rodent;Satiation;Signal Transduction;Small Intestines;Taste Perception;Taste preferences;Testing;Tracer;Training;Translating;Tube;uptake;Work

PROJECT_TITLE: Contribution of Nutrient Delivery Rate to Gut-Brain Axis Signaling in Obesity and Bariatric Surgery

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Human Genome;Organ Transplantation;Precision Medicine;Prevention;Transplantation

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE____________________________________________________________________ Up to 30% of heart transplant recipients develop acute rejection of the new heart within the first post-transplant year. Although they reduce the risk of rejection, contemporary immunosuppressive agents are associated with infection, malignancy, and nephrotoxicity, all of which contribute to post-transplant morbidity and mortality. If heart transplant candidates at low risk for rejection could be identified pre-operatively, a crucial opportunity to personalize immunosuppression without increasing the risk of rejection could be realized. This application proposes to leverage proteomic and transcriptomic profiling to identify circulating pre-transplant biomarkers for post-transplant rejection risk to facilitate a personalized and precision approach to safely minimize immunosuppression and promote post-transplant survivorship.

PI_NAMEs: TRUBY, LAUREN KATHRYN (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Acceleration;Acute;adaptive immunity;Age;allograft rejection;antibody-mediated rejection;biobank;Biological;Biological Assay;Biological Markers;Biological Process;Biology;biomarker discovery;biomarker identification;biomarker validation;career;Caring;Chronic;Chronic Kidney Failure;circulating biomarkers;Classification;Clinical;clinical care;clinical risk;clinically significant;cohort;cost;Data;Diagnosis;differential expression;FGF2 gene;Future;Gene Expression;Gene set enrichment analysis;Genetic Transcription;Goals;Graft Rejection;Grant;Heart;Heart failure;Heart Transplantation;immune activation;Immunity;Immunologics;Immunosuppression;Immunosuppressive Agents;improved;indexing;Infection;Inflammation;insight;interest;IRAK1 gene;Kidney Diseases;life span;Machine Learning;Malignant Neoplasms;Measures;Mediating;Modernization;Molecular;Morbidity - disease rate;mortality;multiple omics;Natural Immunity;nephrotoxicity;novel;optimism;Outcome;Pathway Analysis;Pathway interactions;Patients;Perioperative;Peripheral Blood Mononuclear Cell;personalized approach;Phenotype;Play;post-transplant;precision medicine;Predictive Factor;primary outcome;prospective;protein biomarkers;protein profiling;Proteins;Proteomics;Recurrence;Reporting;Research Personnel;Risk;Risk Factors;Risk Marker;Risk Reduction;ROC Curve;Sampling;Scientist;Serum;sex;Specific qualifier value;survivorship;Technology;Testing;Time;Tissue-Specific Gene Expression;Toxic effect;Transcript;transcriptome sequencing;transcriptomic profiling;transcriptomics;translational physician;Transplant Recipients;Transplantation;Work

PROJECT_TITLE: Pre-Transplant Multiomic Profiling to Quantify The Risk of Rejection Following Heart Transplantation

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M3)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Congenital Structural Anomalies;Cost Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_CITY: MEMPHIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Project Narrative We propose a multi-center trial, within an established research network, to study the use of a medication (inhaled Nitric Oxide) in the management of newborn infants with congenital diaphragmatic hernia (CDH). We will use a novel study design approach to learn about the effects this medication has on the level of oxygen in the blood, the need for heart-lung bypass support, and survival, along with the cost-effectiveness of the medication and how well physicians and centers adopt the new approach. Our objective is to advance the adoption of cost- effective, evidence-based strategies in CDH care, leading to cost-effective improvements in CDH and neonatal outcomes.

PI_NAMEs: BLAKELY, MARTIN LEE;JANCELEWICZ, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Acute;Address;Adopted;Adoption;Affect;Birth;Blood;Cardiopulmonary;Cardiopulmonary Bypass;Caring;Cessation of life;Charge;Child;Child health care;Clinical;clinical care;Clinical effectiveness;Clinical Investigator;Clinical Management;Clinical Trials;cluster randomized design;Cluster randomized trial;Collaborations;collaborative approach;Complex;congenital anomaly;Congenital diaphragmatic hernia;Consensus;cost;cost effective;cost effective treatment;cost effectiveness;Cost Effectiveness Analysis;Critical Illness;Data;data registry;Databases;Dedications;Deimplementation;design;Development;Disease;disease heterogeneity;Disparity;early phase clinical trial;Effectiveness;Enrollment;Equipoise;evidence base;experience;Failure;Family;Foundations;Functional disorder;Goals;Health system;Impairment;implementation outcomes;implementation trial;improved;improved outcome;Individual;Infant;inhaled nitric oxide;innovation;Institution;International;Investigation;Leadership;Learning;Life;Lung;lung failure;Modality;mortality;Multicenter Trials;neonatal care;neonatal outcome;neonate;Newborn Infant;novel;novel strategies;Outcome;Oxygen;participant enrollment;Patient Selection;Patients;Pharmaceutical Preparations;Phase;Physicians;Physiological;postnatal;prevent;primary outcome;Probability;Publishing;Pulmonary Hypertension;Randomized;Recommendation;Registries;Research;Research Design;Research Personnel;Resources;Respiratory Diaphragm;Resuscitation;Savings;secondary outcome;Series;Site;societal costs;standardized care;Testing;treatment strategy;trial design;United States;Variant;Vasodilator Agents

PROJECT_TITLE: Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia - The "NONO trial" - a pragmatic, multi-center, de-implementation, stepped-wedge, cluster-randomized trial

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR (MA)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Congenital Structural Anomalies;Cost Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Infant Mortality;Lung;Neonatal Respiratory Distress;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

PI_NAMEs: HARTING, MATTHEW TIHEN (contact);PEDROZA, CLAUDIA ;YAMAL, JOSE-MIGUEL

PROJECT_TERMS: 3-Dimensional;Acute;Address;Adherence;adherence rate;Adopted;Adoption;Adverse event;adverse event monitoring;Affect;Annual Reports;authority;Big Data Methods;Biometry;Birth;Blood;Budgets;Cardiopulmonary;Cardiopulmonary Bypass;Caring;Case Report Form;Certification;Cessation of life;Child;Child health care;Clinical;clinical care;clinical center;Clinical effectiveness;Clinical Investigator;Clinical Management;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;cluster randomized design;Cluster randomized trial;Collaborations;collaborative approach;Collection;Communication;Communities;Complex;Conflict of Interest;congenital anomaly;Congenital diaphragmatic hernia;cost;cost effective;cost effectiveness;Data;Data Analytics;Data Collection;Data Coordinating Center;data management;data repository;Data Set;data submission;Dedications;Deimplementation;design;Development;Disease;Documentation;Effectiveness;electronic data;electronic data capture system;Electronics;Enrollment;Ensure;Equipoise;Evaluation;Event;evidence base;Evolution;experience;Family;Foundations;Functional disorder;Goals;Health system;implementation trial;improved;Individual;Information Dissemination;inhaled nitric oxide;innovation;Institution;Institutional Review Boards;Insurance;interest;Investigation;Lead;Leadership;Learning;Life;Logistics;Lung;Manuals;meetings;Monitor;mortality;Multicenter Trials;National Heart, Lung, and Blood Institute;Neonatal;neonatal care;neonatal outcome;neonate;Newborn Infant;novel;novel strategies;operation;Outcome;Oxygen;Patients;Pediatric Surgical Procedures;Pharmaceutical Preparations;Phase;Physicians;Policies;postnatal;Preparation;prevent;primary outcome;Procedures;Protocols documentation;Publications;Quality Control;Randomized;recruit;Registries;Reporting;Research;Research Design;Research Personnel;Resources;Respiratory Diaphragm;Resuscitation;Savings;Schedule;secondary outcome;Secure;Site;societal costs;Specific qualifier value;symposium;System;Time;timeline;Training;trial design;Validation;Voting;web site;Work

PROJECT_TITLE: 1/2 Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia - The "NONO trial" - a pragmatic, multi-center, de-implementation, stepped-wedge, cluster-randomized trial


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Physical Activity

ORG_CITY: Boulder

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: NARRATIVE Muscle-generated force is transmitted to tendon across a specialized interface called the myotendinous junction (MTJ). The MTJ is susceptible to injury due to constant exposure of force during physical activity. The objective of this proposal is to identify how the extracellular matrix and mechanical loading establish and maintain the strong linkage between muscle and tendon as this knowledge will be essential for developing therapies to restore functionality to the damaged MTJ.

PI_NAMEs: CALVE, SARAH  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 3-Dimensional;Affect;Cells;clinical translation;Coculture Techniques;Connective Tissue Cells;Development;Disparate;Embryo;Engineering;Event;extracellular;Extracellular Matrix;Extracellular Protein;Fibrin;functional restoration;Gel;Hindlimb Suspension;In Vitro;in vivo;Injury;Knowledge;Label;macromolecule;mechanical force;mechanical load;Mechanics;Membrane;Metabolic;Motility;mouse model;Muscle;Muscle Contraction;Periodicity;Physical activity;Predisposition;Proteins;Proteomics;Role;Signal Transduction;Sports;stress reduction;Technology;Tendon structure;Testing;therapy development;Tissues;transmission process;Trauma;treadmill training;Work

PROJECT_TITLE: Extracellular integration of a cohesive myotendinous junction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-M]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Narrative: This project tests the hypothesis that small extracellular vesicles secreted in the breast cancer microenvironment drive tumor aggressiveness and metastasis. It is relevant to public health because it may identify key molecular determinants driving breast cancer outcome.

PI_NAMEs: PONIK, SUZANNE MARIE;WEAVER, ALISSA M (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: adhesion receptor;autocrine;Autocrine Communication;Automobile Driving;Binding;Breast Cancer Cell;breast cancer metastasis;breast cancer progression;cancer cell;Cell Adhesion Molecules;cell motility;Cell Survival;Distant;Epithelium;exosome;Extracellular Matrix;extracellular vesicles;Fibroblasts;Fibronectins;Grant;Growth;In Vitro;in vivo;Integrins;Invaded;Ligands;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Molecular;Neoplasm Metastasis;Outcome;Paracrine Communication;Primary Neoplasm;Process;Proteins;Public Health;Role;Site;syndecan;Testing;Tissues;tumor;tumor microenvironment

PROJECT_TITLE: Exosome secretion in breast cancer progression

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN DIEGO

ORG_DEPT: NUTRITION

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project Narrative  The objective of this research is to culturally tailor a commercially available mindfulness-meditation mobile app for African American (AA) adults and assess its feasibility. A User-Centered Design (UCD) approach will be used to co- develop a culturally tailored app prototype and will be tested in a pilot RCT in AA adults with elevated levels of stress. This proposal will advance our understanding of methods to culturally tailor commercially available mindfulness- meditation apps which may, in the long-term, increase access to mental health care and reduce mental health disparities in AA adults.

PI_NAMEs: GREEN, JENNIFER LOGAN (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: Adherence;Adult;African American;Anxiety;base;Belief;Benchmarking;career;Cellular Phone;Clinical Trials;Collaborations;Communities;cost;COVID-19 pandemic;COVID-19 pandemic effects;cultural values;Data;Dedications;demographics;design;Development;digital;digital health;Distress;Educational workshop;efficacy testing;ethnic minority population;experience;Feedback;Focus Groups;Foundations;Funding;Future;Goals;health disparity;Health education;health equity;Health Services Accessibility;ideation;Improve Access;improved;industry partner;innovation;instructor;Intervention;Interview;K-Series Research Career Programs;Language;Location;Manuscripts;Measures;Mediator;Meditation;Mental Depression;Mental Health;Mental Health Services;Mentors;Mentorship;Methods;mHealth;Mind;Mind-Body Intervention;Mind-Body Method;mindfulness;mindfulness meditation;mobile application;Modification;National Center for Complementary and Integrative Health;Participant;Pattern;perceived stress;Perception;Personal Satisfaction;Phase;post intervention;Preparation;Prevalence;Process;product development;programs;prototype;psychological distress;public health emergency;Race;racial discrimination;racial minority population;Randomized;Recording of previous events;recruit;Reduce health disparities;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;satisfaction;self-compassion;social;social stigma;Source;statistics;Stress;stress management;Stressful Event;Structure;Surveys;Testing;tool;Training;Training Programs;treatment comparison;Underserved Population;United States National Institutes of Health;user centered design;virtual

PROJECT_TITLE: Culturally tailoring a mindfulness meditation mobile app to reduce psychological distress in African American adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (05)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Patient Safety;Prevention

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE A large number of patients with Alzheimer’s Disease and Related Dementias (ADRD) undergo surgery, but the nature of their risk for postoperative complications as well as the decisions that can reduce this risk are unknown. This project will link electronic medical records data with administrative healthcare claims data to characterize the extent to which surgical patients with ADRD are at increased risk for postoperative complications and to identify clinical decisions (such as the use of anesthetic gases and choice of discharge location) that can reduce this risk. The results of this study will improve shared decision making and healthcare outcomes for surgical patient with ADRD by increasing what is known about the increased risks of surgery to these patients as well as the ways to manage these risks.

PI_NAMEs: SUN, ERIC  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: adverse outcome;Age;Aging;Alzheimer's disease patient;Alzheimer's disease related dementia;Anesthetic Gases;Anesthetics;care outcomes;Caring;Clinical;comorbidity;Computerized Medical Record;Data;Data Set;Databases;evidence base;evidence based guidelines;Face;Future;Goals;Guidelines;Health;Healthcare;high risk;Hip Fractures;improved;Incidence;Intervention;Knowledge;Length of Stay;Link;Location;Measures;Mediating;Medical History;Medicare;Modeling;modifiable risk;Nature;Nerve Block;novel;older adult;Operative Surgical Procedures;opioid use;Orthopedic Surgery;Outcome;Outcome Assessment;Patients;Perioperative;Perioperative Care;Pharmaceutical Preparations;Policies;Population;population health;Positioning Attribute;Postoperative Complications;Postoperative Period;Process;randomized trial;Registries;Risk;Risk Assessment;Risk Factors;Risk Management;Risk Reduction;shared decision making;surgery outcome;Surgical complication;surgical risk;systematic review;Testing;Time;time use

PROJECT_TITLE: Usage of Novel Linked Databases to Improve the Perioperative Management of Patients With Alzheimers Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: The proposed research is relevant to public health because its goal is to enable the diagnosis of two important brain pathologies that account for more than 20% of dementia cases in those who are 85 years and older. This age group is the fastest growing segment of the population and has the highest rates of dementia. Around half of those suffering from dementia by mid-century will belong to this group highlighting the importance of studies dedicated to the causes of dementia in this older age.

PI_NAMEs: SAJJADI, SEYED AHMAD  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Accounting;age group;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapy;Amnestic Disorder;Antinuclear Antibodies;arm;Atrophic;Autoimmune biomarker;Autoimmunity;Autopsy;Biological Markers;biomarker discovery;Blood;Blood specimen;Brain;brain magnetic resonance imaging;Brain Pathology;California;Clinical;Clinical Trials;Cognitive;cohort;Complement;Data;Dedications;Dementia;Diagnosis;Diffusion Magnetic Resonance Imaging;effectiveness evaluation;Elderly;ethnic diversity;ethnoracial;fluorodeoxyglucose positron emission tomography;Frequencies;Glial Fibrillary Acidic Protein;Gliosis;Glucose;Goals;Grant;Guidelines;High Prevalence;hippocampal atrophy;hippocampal sclerosis;Hippocampus;human old age (65+);Image;imaging biomarker;Impaired cognition;Impairment;improved;in vivo;Individual;Inferior;Inflammation;inflammatory marker;Interleukin-6;Investigation;Lead;Life;limbic-predominant age-related TDP-43 encephalopathy;Liquid substance;Magnetic Resonance Imaging;Measures;Medial;Memory;Memory impairment;Metabolism;Methodology;Methods;mixed dementia;multimodality;neuropathology;Neuropsychology;novel;novel strategies;Older Population;Participant;Pathologic;Pathology;Pathway interactions;Patients;Performance;PGRN gene;Plasma;Population;Population Heterogeneity;Positron-Emission Tomography;potential biomarker;Prevalence;Prevalence Study;protein TDP-43;Proteins;Public Health;Research;Resources;Risk Factors;Sampling;Scheme;serological marker;Serology;Staging;Structure;targeted treatment;Testing;tool;Universities;white matter;Work

PROJECT_TITLE: Diagnosis and Risk factors of hippocampal sclerosis of aging and limbic predominant age related TDP-43 encephalopathy; common Alzheimer’s mimics

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: Portland

ORG_NAME: BOULDER CARE, INC.

ORG_STATE: OR

PHR: Project Narrative RFA-DA-24-018 Field-Deployable, Low-Cost Point-of-Need Approaches and Technologies to Lower the Barriers to Substance Use Disorders (SUD) Diagnosis and Treatment Opioid Use Disorder (OUD), already a life-threatening condition, has additional risk in certain settings such as correctional reentry, Emergency Departments, Tribal Nations, residential substance use disorder treatment, and the perinatal period. We propose just-in-time provision of smartphones with needed connectivity to allow for enrollment in and continuity of telehealth that includes buprenorphine. Our efforts will be co-led and guided by partner researchers with lived experience in a Phase I that informs scaled efforts in Phase II.

PI_NAMEs: PAPES, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: FLOOD, MORRIS

PROJECT_TERMS: Accident and Emergency department;addiction;Address;Admission activity;Affect;American;analog;Anoxic Encephalopathy;Attention;barrier to care;Brain Death;Buprenorphine;buprenorphine treatment;Capital;care providers;Caring;Cellular Phone;Clinical;Collaborations;Communities;Comprehensive Health Care;cost;COVID-19 pandemic;Dedications;Development;Diagnosis;distrust;Dose Limiting;Drug user;effective therapy;Effectiveness;Emergency department visit;Empathy;Employment;Enrollment;Ensure;experience;Focus Groups;functional outcomes;functional status;Geographic Locations;Geography;Grant;healing;Health;Health Insurance;health related quality of life;Health Services Accessibility;high risk;Homelessness;Hospitals;improved;Infection;Interview;Jail;Life;Lived experience;Location;marginalization;Measures;Medicaid;medical attention;Methadone;Modeling;Monitor;mortality;opioid agonist therapy;opioid use disorder;Outcome;Overdose;pandemic disease;Participant;participant retention;Patient Care;Patient-Focused Outcomes;Patients;Perinatal;perinatal period;Persons;Pharmaceutical Preparations;Phase;Poverty;primary endpoint;Prisons;Privacy;programs;Provider;public health emergency;Publishing;Punishment;Qualifying;Quality of life;Recovery;recruit;Rehabilitation therapy;Relaxation;remote therapy;Reporting;Research;Research Personnel;Residential Treatment;Resource-limited setting;Risk;Rural;rurality;Services;Site;Small Business Innovation Research Grant;social stigma;standard care;Substance Use Disorder;success;Survivors;Suspensions;Technology;technology platform;telehealth;telehealthcare;Telephone;Testing;Time;tool;Transportation;treatment as usual;treatment duration;treatment site;tribal Nation;Trust;Unemployment;Visit;Visual;Vulnerable Populations;waiver;wireless fidelity;Withdrawal;wound

PROJECT_TITLE: Right Tools, Right Time, Right Place: Telehealth for Opioid Use Disorder in Vulnerable Settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 CEM-S (M1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: BOSTON

ORG_NAME: JUDGE BAKER CHILDREN'S CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE This high-risk, high-reward proposal addresses racial health equity and challenges the typical scientific paradigm through innovative approaches in youth substance use prevention for Native Hawaiian and Pacific Islander (NHPI) rural populations. Implementation science and participatory methods will shift power, ownership, and responsibility from the project's inception to NHPI communities to actively promote adoption and sustainment of culturally grounded substance use prevention. Community-led innovation tournaments and ecological momentary assessment will produce new generalizable findings for other indigenous and underserved populations, promoting the spread and reach of culturally grounded substance use prevention.

PI_NAMEs: OKAMURA, KELSIE  (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Address;adolescent substance use;Adoption;Award;Clinical;Communities;community based participatory research;Ecological momentary assessment;Education;Educational Curriculum;Family;Fostering;Funding;future implementation;Geography;Grant;Ground Substance;Hawaii;health equity;high reward;high risk;Immigrant;implementation barriers;implementation efforts;implementation evaluation;implementation facilitation;implementation process;implementation research;implementation science;implementation strategy;innovation;Institution;Intervention;Japanese;Leadership;Mental Health Services;Methods;National Institute of Drug Abuse;Native Hawaiian or Other Pacific Islander;Native-Born;novel;Ownership;Pharmaceutical Preparations;Population;Prevention;Process;Psychologist;Race;Racial Equity;Research;Research Personnel;Role;Rural;rural area;Rural Population;Scientific Inquiry;Scientist;Shapes;skills;Structure;substance use;substance use prevention;System;teacher;Testing;Time;Underserved Population;Voice;Work;Youth

PROJECT_TITLE: Community-driven drug prevention implementation strategies for Native Hawaiian and Pacific Islander youth in rural Hawai'i

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-E (M1)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: PROJECT NARRATIVE Declared an “Urgent/Critical Threat” by both CDC and WHO, Candida auris infects immunosuppressed patients and is often untreatable due to resistance to all available antifungal drugs resulting in a high mortality rate of approximately 60%. We propose investigating the role of C. auris cell surface proteins in virulence mechanisms and developing novel vaccine strategies.

PI_NAMEs: SINGH, SHAKTI  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Address;Adhesions;Adhesives;Agglutinins;aluminum sulfate;Animal Model;anti-fungal agents;Antigens;Binding;California;Candida;Candida albicans;Candida auris;Candidiasis;Cardiac;career development;Categories;Catheters;Cell Surface Proteins;Cell Wall;Cells;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Trials;clinically relevant;Codon Nucleotides;combat;cost effective;Coupled;COVID-19 vaccination;CRISPR/Cas technology;Data;Death Rate;Devices;Disseminated candidiasis;Dose;drug resistance development;efficacy testing;Encapsulated;Environment;environmental enrichment for laboratory animals;Epitopes;Ethics;Exhibits;experience;Faculty;Family;fungus;Genes;Genetic Transcription;global health;Goals;health care settings;healthcare-associated infections;Hematogenous;high risk;Human;Hyphae;Immune;Immune response;Immunocompromised Host;immunogenic;immunogenicity;Immunologist;Immunology;improved;in silico;In Vitro;in vivo;Infection;infection risk;innovation;Invaded;Leadership;Life;lipid nanoparticle;Los Angeles;Medical center;Medical Device;Mentors;Messenger RNA;Microbial Biofilms;Modification;Monoclonal Antibodies;mouse model;mRNA lipid nano particle vaccine;Multi-Drug Resistance;multi-drug resistant pathogen;Mus;mutant;N-terminal;novel vaccines;Nucleosides;Orthologous Gene;pathogen;Pathogenesis;Patients;Phagocytes;Pharmaceutical Preparations;Phase;Plasmid Cloning Vector;plasmid DNA;Plasmids;Positioning Attribute;Postdoctoral Fellow;posttranscriptional;prevent;Preventive;Productivity;professor;promoter;protective efficacy;Proteins;Public Health;Publishing;Recombinants;Reporting;Research;Research Personnel;Resistance;resistance in Candida auris;Resources;responsible research conduct;RNA vaccine;Role;Scientist;Scourge;Sepsis;Serum;Shunt Device;skills;Skin;Skin colonization;Stents;Structure;success;Surface;Surface Antigens;Tail;Technology;Testing;therapeutic target;therapeutic vaccine;Tissues;Training;trait;Universities;urinary;Vaccination;Vaccine Antigen;vaccine candidate;vaccine development;vaccine strategy;Vaccines;Venous;Virulence;Vulvovaginal Candidiasis;World Health Organization;Yeasts

PROJECT_TITLE: Role of multi-drug resistant Candida auris Hyr1 / Iff-like proteins in virulence and their potential as vaccine targets

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Patient Safety

PHR: PROJECT NARRATIVE Persons with kidney disease are 16 times more likely to need surgery and have a higher risk of complications from surgery compared to patients with normal or near normal kidney function. This proposal will study the link between how we perform hemodialysis before surgery and complications after surgery, including heart attack, stroke, heart failure, irregular heart rhythms, or infections. Completion of this work will provide health care providers with important information about how to prevent complications when persons living with kidney disease need surgery.

PI_NAMEs: FIELDING-SINGH, VIKRAM  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Address;adverse outcome;Arrhythmia;Automobile Driving;Award;career;Clinical Investigator;Clinical Research;Clinical Trials Design;Cohort Studies;Consensus;Data;Databases;Day Surgery;design;Development;Dialysis procedure;Discipline;Electronic Health Record;End stage renal failure;Environment;epidemiology study;evidence base;Excision;experience;Feedback;Funding;Future;Goals;Guidelines;Health;Health Personnel;Health Services;Heart failure;heart rhythm;Hemodialysis;high risk;Hypotension;improved;Infection;innovation;Intervention;Intervention Trial;Ischemic Stroke;Kidney Diseases;Knowledge;Link;Maintenance;Master of Science;Medicare claim;Mentors;Mentorship;Methodology;Morbidity - disease rate;mortality;mortality risk;Multicenter Trials;multidisciplinary;Myocardial Infarction;novel;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;Pattern;Perioperative;perioperative mortality;Persons;Policy Maker;Population;Positioning Attribute;Postoperative Complications;Postoperative Period;prevent;Procedures;prospective;prospective test;Protocols documentation;Provider;Randomized;randomized trial;randomized, clinical trials;Recommendation;recruit;Renal function;Reporting;Research;Research Personnel;Risk;safety and feasibility;safety outcomes;Schedule;skills;Statistical Methods;Stroke;Surgeon;Surgical complication;surgical risk;Survival Analysis;Techniques;Testing;Time;time interval;Training;trial comparing;Universities;Work

PROJECT_TITLE: Toward optimizing dialysis in the perioperative period

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: Los Angeles

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE By revealing how employment insecurity (EI) relates to substance use and the contexts and populations that buffer or amplify these effects, this study can provide precision targets for policy makers. Additionally, such definitive findings may dispel stigma that substance use is primarily a cause and not a consequence of EI, which can further support broad adoption of employment-enhancement programs and policies as a means of combating the nation’s addiction crisis. The current secondary data analysis study will provide vital evidence that can guide public health efforts in preventing EI from fueling the national drug crisis today and during future turbulent economic times by learning from the most recent societal crisis with economic volatility and addressing decades- long and unresolved issues in the relevant science base.

PI_NAMEs: LEE, JUNGEUN OLIVIA  (contact)

PROGRAM_OFFICER_NAME: PARKER, ERIN MARGARET

PROJECT_TERMS: addiction;Address;Adoption;Adult;Affect;Alcohol consumption;American;Area;base;behavioral economics;Buffers;Cannabis;Characteristics;Cigarette;coping mechanism;COVID-19 pandemic;Data;Data Analyses;Disadvantaged;Distress;Drug usage;Economic Models;Economics;Electronic cigarette;Employment;Employment Status;Environmental Health;environmental stressor;ethnic minority;Ethnic Origin;experience;Frequencies;Future;Growth;Income;Individual;information gathering;Internet;Intervention;Learning;Link;long term consequences of COVID-19;low socioeconomic status;Mediating;Mental Health;Modeling;Movement;Nature;Neighborhoods;novel;Occupations;Pathway interactions;Persons;Pharmaceutical Preparations;Policies;Policy Maker;Population;prevent;Process;programs;prospective;Public Health;Race;racial minority;Recovery;reduced substance use;residence;Resources;Respondent;Rewards;Risk;Schedule;Science;Shapes;social;social contact;social stigma;socioeconomics;sound;Source;Speed;Stress;Subgroup;substance use;Surveys;Testing;Time;Uncertainty;Underemployment;Unemployment;Wages

PROJECT_TITLE: Employment Insecurity and Substance Use in U.S. Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-E (M1)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD)

ORG_CITY: RICHLAND

ORG_NAME: BATTELLE PACIFIC NORTHWEST LABORATORIES

ORG_STATE: WA

PHR: Project Narra�ve This project will help understand the impact of bacteriophage, viruses infec�ng bacteria, on human health by developing new computa�onal tools to understand the func�on of these viruses. The results of this project could illuminate causes of diseases that are linked to the microbiome and help provide therapies for treatment of the microbiome to enhance health.

PI_NAMEs: MCDERMOTT, JASON EDWARD (contact);WHEELER, TRAVIS JOHN

PROGRAM_OFFICER_NAME: MELILLO, AMANDA A

PROJECT_TITLE: Computational tools for illuminating the dark matter of the human virome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-X (50)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE [Original Proposal] The proposed study will examine midlife women's relationships and support exchanges with their late adolescent and adult children, as well as with other kin and non-kin, and the implications of these relationships and exchanges for women's psychosocial well-being. The experienced bi-national team will collect and analyze survey and in-depth interview data building upon an existing longitudinal panel of women in rural Mozambique, a setting that in many respects is typical of sub-Saharan Africa. The results of this study will fill important gaps in our understanding of intergenerational and community relationship dynamics and their consequences for women's welfare in rapidly changing resource-limited patriarchal contexts and will inform policies aimed at improving health and well-being of rural women and at optimizing health and social services for that vulnerable population segment.

PI_NAMEs: AGADJANIAN, VICTOR  (contact);HAYFORD, SARAH R

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Adolescent;Adult Children;Affect;Africa South of the Sahara;Aging;Anxiety;Characteristics;Child;child bearing;Child Rearing;Collaborations;Collection;Communities;Community Surveys;Coping Skills;Data;Data Collection;Databases;Decision Making;Economic Conditions;Economics;Education;Emotional;Employment;experience;Exposure to;Family;Gender;Generations;Happiness;Health;Health Services;Household;human old age (65+);Husband;improved;Income;interest;intergenerational;Interview;Investments;labor force participation;Labor Migrations;Laws;Life;Link;Low income;Marriage;Measures;member;men;Mental Depression;Mental Health;middle age;Midlife women;migration;Mozambique;multidisciplinary;Nutritional;Outcome;Parent-Child Relations;Parents;Participant;Pattern;Personal Satisfaction;physical conditioning;Physical shape;Policies;Process;Productivity;psychosocial outcome;psychosocial wellbeing;Recording of previous events;Reproduction;reproductive;Research;residence;Residential Mobility;Resources;Rural;Rural Community;rural families;rural setting;safety net;satisfaction;Scholarship;Security;Self Efficacy;Shapes;Site;skills;social;Social Change;Social Functioning;Social Interaction;social relationships;Social support;Social Work;socioeconomics;Standardization;stressor;Structure;Surveys;Time;transition to adulthood;Uncertainty;Variant;Vulnerable Populations;welfare;Woman;Women's Health

PROJECT_TITLE: Women’s Social Ties and Psychosocial Well-Being in a Resource-Limited Patriarchal Setting: A Longitudinal Perspective


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Health Services;Networking and Information Technology R&D (NITRD);Neurosciences;Opioid Misuse and Addiction;Opioids;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: Lake Forest

ORG_NAME: REKOVAR INC.

PHR: PROJECT NARRATIVE Rekovar is developing a low-cost wearable monitoring system that integrates wirelessly with a mobile device to allow real- time monitoring of the baby’s physical and physiological state and its ability to sleep, eat, and be nurtured while undergoing neonatal abstinence syndrome (NAS). This device has significant impact in helping reduce both hospital stay and costs as neonates receiving pharmacological treatment are usually in the NICU away from family and non- pharmacological care. Our interest lies with respect to proper neonatal care, where separate procedures occur for essential neonatal needs and needs for neonates undergoing withdrawal, and by using this monitoring device to assess addicted neonates undergoing withdrawal, caregivers are provided the better ability of treating the right neonatal needs with the appropriate procedure in hospitals.

PI_NAMEs: AL FARUQUE, MOHAMMAD ABDULLAH;SHARAREH, SHIVA  (contact);TSENG, PETER

PROGRAM_OFFICER_NAME: ANGELONE, LEONARDO MARIA

PROJECT_TERMS: Accelerometer;Acoustics;Adult;Agreement;Algorithms;Ambulatory Monitoring;Area;Behavioral;Biochemical;Biomechanics;biophysical properties;Biosensing Techniques;Biosensor;Birth;Body Temperature;Businesses;Calibration;California;care costs;Caregivers;Caring;Charge;Classification;Clinical;Clinical Trials;Collaborations;Commercial grade;commercialization;cost;County;Crying;Data;Data Analytics;deep learning;Dehydration;Detection;Development;Devices;Diagnosis;digital;digital assessment;Drug Interactions;Eating;efficacy evaluation;Event;experience;Family;flexibility;Funding;Galvanic Skin Response;Guidelines;handheld mobile device;Health Personnel;Health Professional;Heart Rate;Hospital Costs;Hospitals;Image;improved;Infant;innovation;Intellectual Property;interest;Intervention;Investigation;Length of Stay;Marketing;Measures;Mechanics;Medical Care Costs;Medical center;Methods;Minor;Monitor;monitoring device;Motion;Multicenter Studies;Muscle;Neonatal;Neonatal Abstinence Syndrome;neonatal care;Neonatal Intensive Care Units;neonate;Neonatology;New Mexico;Newborn Infant;novel;Nurses;Nursing Assessment;Opiate Addiction;opioid exposure;opioid withdrawal;Oranges;Oxygen;patient portal;Patient-Focused Outcomes;Patients;pediatric department;Pediatric Hospitals;Pediatrics;perinatal medicine;Pharmaceutical Preparations;Pharmacological Treatment;Phase;Physician Executives;Physiologic pulse;Physiological;prenatal exposure;Procedures;Process;Production;prototype;psychologic;Pulse Oximetry;real time monitoring;Reporting;response;Risk;Running;safety assessment;Sales;Seizures;sensor;Services;Severities;Skin;Sleep;standard of care;Substance Withdrawal Syndrome;success;Sweating;Sympathetic Nervous System;Symptoms;System;Tablets;Temperature;Testing;therapy duration;Time;tool;Toxic effect;treatment response;treatment risk;Tremor;United States;United States National Institutes of Health;Universities;Validation;validation studies;verification and validation;visual learning;wearable device;wearable monitor;wearable sensor technology;wireless;Withdrawal;wristband

PROJECT_TITLE: Wireless withdrawal detection and monitoring system for neonatal abstinence syndrome.


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Stroke is the leading cause of disability in the United States, leaving a substantial number of survivors with permanent weakness. Neuromodulation of sensorimotor areas using physiologically targeted low-frequency stimulation is an innovative new direction to facilitate recovery of motor function. Our proposal seeks to optimize stimulation parameters as well as to develop electrophysiological makers of network function that delineate underlying mechanisms of action.

PI_NAMEs: GANGULY, KARUNESH  (contact);MORECRAFT, ROBERT J;ROBERTS, JEFFREY A

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Affect;Animals;Area;Brain;Chronic;Data;design;dimension reduction;disability;Distant;Electric Stimulation;Electrophysiology (science);Engineering;Fingers;Frequencies;Generations;Goals;grasp;Hand;hand dysfunction;Human;improved;in vivo;Injury;innovation;Lesion;Link;Medicine;Methods;Motor;Motor Cortex;Motor disability;motor function recovery;motor impairment;motor recovery;Motor Skills;Movement;Nature;network models;neural;neural network;Neurons;neurophysiology;neuroregulation;Neurosciences;nonhuman primate;novel;Performance;Phase;Physiological;Population Dynamics;post stroke;Primates;Process;Randomized;Rattus;Recovery;Research;Residual state;Sensory;sensory cortex;skills;Somatosensory Cortex;Speed;stereotypy;Stroke;stroke model;stroke patient;stroke survivor;Survivors;System;Techniques;Testing;Therapeutic;therapeutic target;Training;United States;Upper Extremity;Work

PROJECT_TITLE: Modulating Low-Frequency Cortical Population Dynamics to Augment Motor Function After Stroke

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative  This research seeks to understand how O-GlcNAc (O-linked β-N-acetylglucosamine) glycosylation, an essential, abundant posttranslational modification of proteins, contributes to the onset and progression of Alzheimer’s disease and other related dementias. The insights gained will further our understanding of how specific changes in O-GlcNAc glycosylation regulate cellular functions and drive toxic aggregation of proteins that are hallmarks of these diseases. A major goal is to reveal new targets for therapeutic intervention.

PI_NAMEs: HSIEH-WILSON, LINDA C (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Behavior;Bioinformatics;Biological;Biological Process;Biology;Brain;Carbohydrates;case control;cell growth regulation;Cell Physiology;cell type;Chemicals;chemoproteomics;clinically relevant;Collaborations;Collection;combat;Complex;CREB1 gene;Cryopreservation;Data;Data Set;Dedications;Dementia;Detection;Development;Disease;disorder risk;engineered stem cells;Enzymes;Epigenetic Process;epigenetic regulation;Event;excitotoxicity;Gene Expression Regulation;Genetic Engineering;Genetic Transcription;Genome;Glycoproteins;glycosylation;Goals;Grant;human disease;human induced pluripotent stem cells;insight;insulin signaling;Link;Liquid substance;Maps;Mass Spectrum Analysis;Membrane;Methods;mild cognitive impairment;Modification;Monitor;Mutation;Nerve Degeneration;neurodegenerative dementia;Neurodegenerative Disorders;Neurology;Neurons;new therapeutic target;novel;novel therapeutic intervention;Nucleic Acids;O-GlcNAc transferase;Organelles;Pathogenesis;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phase;Physical condensation;Physiological;Polysaccharides;Post-Translational Protein Processing;programs;progressive neurodegeneration;protein aggregation;Protein Region;Proteins;Proteome;Regulation;Research;response;Role;Sampling;Signal Transduction;Site;Specificity;Stimulus;stoichiometry;stress granule;Structure-Activity Relationship;Synapses;Synaptic plasticity;System;Tertiary Protein Structure;Testing;Therapeutic Intervention;therapeutic target;Time;Tissues;tool;transcription factor;tumor metabolism

PROJECT_TITLE: Chemical Approaches to Understand O-GlcNAc Glycosylation and Its Roles in Neurodegeneration

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: The goal of this proposal is to define the role of the SigmaR1-IRE1a-XBP1 signaling axis in astrocytes during CNS inflammation. To achieve this goal, we propose to apply spatial transcriptomics, scRNA-seq, and genetic and pharmacologic perturbations to the analysis of MS patient samples and murine disease models. In summary, this project investigates a novel molecular pathway in astrocytes using cutting edge techniques to define basic mechanisms that control CNS inflammation and identify novel therapeutic targets.

PI_NAMEs: WHEELER, MICHAEL ALEX (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Animal Model;Astrocytes;Autoimmune Responses;Binding Proteins;Blood - brain barrier anatomy;Cells;Cellular Stress;Central Nervous System;Central Nervous System Diseases;Chronic;clinically relevant;cost;Data;Development;disability;Disease;disease model;Economic Burden;efficacious treatment;Endoplasmic Reticulum;Environmental Pollutants;Environmental Risk Factor;Enzymes;Experimental Autoimmune Encephalomyelitis;Factor X;Gene Expression;Genetic;Genetic Transcription;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Granulocyte-Macrophage Colony-Stimulating Factor Receptors;Health;Herbicides;Homeostasis;Human;immune cell infiltrate;Inflammation;Inflammatory;inhibitor;Inositol;Lesion;Link;Mediating;Mentors;Metabolic Control;Microglia;Modeling;Molecular;monocyte;mouse model;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;Mus;Myelin;Natural Immunity;Nerve Degeneration;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;Neuroglia;Neurologic Deficit;Neurons;neurotoxic;new therapeutic target;novel;Pathogenesis;Pathogenicity;Pathway interactions;Peptide Initiation Factors;pharmacologic;Phase;Play;Population;programs;Proteins;receptor;receptor expression;recruit;Refractory;Regulation;Research Personnel;response;Role;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule;synergism;T-Cell Activation;T-Lymphocyte;targeted treatment;Techniques;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;therapy development;transcription factor;Transcriptional Activation;transcriptomics;translational potential;Work;young adult

PROJECT_TITLE: Molecular Control of Astrocytes in CNS Inflammation

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: This research proposal will inform public health decisions, as our findings will transform how clinicians and scientists think about neurodegeneration in Parkinson's Disease and Parkinsonism's. Understanding factors that render cells vulnerable to degeneration and the common and distinct mechanisms of molecular dysregulation underlying the disease states, particularly among inherited or familial subtypes, will increase the accuracy and precision to predict risk, improve diagnosis and establish a new framework for innovative therapeutic strategies in line with the mission of the NIH to improve the human condition.

PI_NAMEs: BLANCHARD, JOEL WILLIAM (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Affect;American;Autopsy;autosome;biological adaptation to stress;Biological Models;Brain;Candidate Disease Gene;candidate identification;candidate validation;Caregivers;Cell Death;Cell Line;Cell model;Cell Physiology;cell type;Cells;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Correlation Studies;CRISPR-mediated transcriptional activation;Data;Data Set;Diagnosis;Disease;disease model;disorder risk;DNA Damage;Dopamine;dopaminergic neuron;early onset;Environment;Flow Cytometry;Fluorescent Dyes;Functional disorder;Gene Expression;Genes;Genetic;Genotype;Goals;Human;human pluripotent stem cell;Hypothalamic structure;Image;improved;Individual;Inherited;innovation;insight;knock-down;Knock-in;Knowledge;Lentivirus Vector;Lipids;loss of function;Mendelian disorder;Metabolism;Midbrain structure;Mission;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;molecular subtypes;motor impairment;multiple omics;Mutagenesis;Mutation;Nerve Degeneration;Neurons;new therapeutic target;novel;novel strategies;Organoids;Outcome;Oxidative Stress;Oxidative Stress Pathway;PARK7 gene;PARK9 gene;Parkinson Disease;Parkinsonian Disorders;Pathologic;Pathology;Pathway Analysis;Pathway interactions;patient stratification;Patients;Pattern;pharmacologic;Phenotype;Population;Population Analysis;Prevention;Prevention strategy;Printing;Prosencephalon;protein aggregation;Proteins;Proteomics;Public Health;Reactive Oxygen Species;Reporter;Research;Research Proposals;response;risk prediction;Scientist;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Source;sporadic Parkinson's Disease;System;Technology;Testing;Therapeutic;Time;Tissues;tool;trafficking;transcriptomics;Tyrosine 3-Monooxygenase;United States National Institutes of Health

PROJECT_TITLE: Understanding Cell-type Vulnerability and Oxidative Stress Pathology in Parkinson's Disease Using Isogenic Human Dopaminergic Neurons

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Rare Diseases

ORG_DEPT: NEUROSURGERY

PHR: Principal Investigator: Chen, Lu Project Narrative This application proposes to use state-of-art genetic tools to explore the molecular mechanisms of retinoic acid- mediated homeostatic plasticity in the mouse hippocampal neurons. In identifying molecular players involved in different cellular events of synaptic RA signaling, this application will contribute to a better understanding of the synaptic and circuit underpinning of mental illness. PHS 398/2590 (Rev. 11/07) Page 1 Project Narrative

PI_NAMEs: CHEN, LU  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Address;Adult;Affect;AMPA Receptors;Animals;Behavioral;Binding;Brain-Derived Neurotrophic Factor;Cell Adhesion Molecules;Cognitive deficits;cognitive function;Coupled;Data;Development;Disease;Drug Targeting;environmental enrichment for laboratory animals;Event;Excitatory Synapse;Exhibits;flexibility;FMR1 gene;Fragile X Syndrome;Functional disorder;Funding Opportunities;Genetic;Genetic Transcription;Goals;Hippocampus;Human;Impairment;in vivo;Inherited;Inhibitory Synapse;insight;Intellectual functioning disability;Investigation;Laboratories;Learning;Link;Mediating;Mental disorders;Modeling;Molecular;mouse model;Mus;Mutation;Nature;Nervous System Disorder;neural circuit;Neurons;neuropsychiatric disorder;Neurosciences;new therapeutic target;novel;Patients;Phenotype;Physiological;postsynaptic;presynaptic;prevent;Principal Investigator;Process;Proteins;Regulation;Research;Research Project Grants;response;Retinoic Acid Receptor;retinoic acid receptor alpha;RNA Splicing;Role;Runaway;Sensory;Series;Shapes;Signal Pathway;Signal Transduction;Structure;Symptoms;Synapses;synaptic function;Synaptic plasticity;Testing;tool;trafficking;Translations;Tretinoin;Variant;Work

PROJECT_TITLE: A molecular investigation of retinoic acid-dependent homeostatic synaptic plasticity

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_CITY: SYDNEY

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: UNIVERSITY OF NEW SOUTH WALES

PHR: PROJECT NARRATIVE The scale of opioid harms in the US and globally requires urgent action to improve efforts to reduce such harms. The proposed project will leverage the strong data linkages capacity in the US (Rhode Island, Wisconsin, Colorado, and Massachusetts), Australia (New South Wales), and the United Kingdom (Scotland), to transform the evidence base on the prevalence of opioid use disorder and the impact of opioid agonist treatment as a strategy to prevent opioid harm. The study team will project where benefits can be gained from expanded access to opioid agonist treatment, including in which settings and targeted to which subpopulations, and make the analytic code and resources publicly available to facilitate replications in other jurisdictions.

PI_NAMEs: DEGENHARDT, LOUISA  (contact);HICKMAN, MATT ;MARTIN, NATASHA

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Acceleration;Address;administrative database;Advocacy;Australia;Bayesian Modeling;Buprenorphine;Calibration;Cessation of life;Characteristics;Client;Clinical;Code;cohort;Colorado;Complex;Country;Data;Data Linkages;Documentation;Drug abuse;Ensure;Equation;Ethics;Evaluation;Event;evidence base;Geography;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Hepatitis C Transmission;heroin use;HIV/HCV;Household;Imprisonment;improved;Individual;International;Intervention;Link;Lived experience;manufacture;Massachusetts;mathematical model;Measures;Medicine;Methadone;Methodology;Methods;Modeling;models and simulation;mortality;New South Wales;novel;Opioid;opioid agonist therapy;opioid epidemic;opioid overdose;opioid use disorder;Outcome;Overdose;overdose death;Parameter Estimation;Pattern;Persons;Pharmaceutical Preparations;Policies;Policy Maker;Population;prescription opioid;Prevalence;prevent;Provider;Records;Research;Research Design;Research Personnel;Resources;response;Rhode Island;scale up;Scotland;Service delivery model;simulation;Site;Stimulant;Subgroup;Surveys;System;Testing;Time;treatment program;treatment research;United Kingdom;United States;Variant;Wisconsin;Work

PROJECT_TITLE: TRANSFORM - Transforming the evidence base on estimating prevalence of opioid use disorder and expanded access to interventions to prevent drug related deaths: an international data linkage study


ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative Deep brain stimulation (DBS) has been FDA approved for managing several brain disorders, including Parkinson’s disease (PD), and has been increasingly used to treat patient over the past couple decades. However, the therapeutic mechanisms of DBS remain largely unknown. This study aims to systematically study the neural circuits involved in PD, and the therapeutic mechanisms of DBS using novel single cell voltage imaging techniques.

PI_NAMEs: HAN, XUE  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Affect;alpha synuclein;Anatomy;Basal Ganglia;behavioral study;Biological Markers;Biophysics;Brain;Brain Diseases;Cells;Chronic;Clinical Research;Corpus striatum structure;Deep Brain Stimulation;design;disease model;Dopamine;Dopamine Receptor;dopaminergic neuron;Electric Stimulation;Electrophysiology (science);Epilepsy;Essential Tremor;Event;FDA approved;Frequencies;Functional disorder;Future;Goals;Image;imaging study;Imaging Techniques;Implanted Electrodes;Individual;insight;Link;Measures;Membrane;Mental disorders;millisecond;Modeling;Motor;motor disorder;mouse model;Movement;Mus;Nervous System Disorder;neural circuit;Neurons;novel;Obsessive-Compulsive Disorder;Optics;Output;Oxidopamine;Parkinson Disease;Pathologic;Pathology;Pathway interactions;Patients;Pattern;pre-formed fibril;Primates;Resolution;segregation;Structure;Structure of subthalamic nucleus;Synapses;Therapeutic;Therapeutic Effect;Time;Transgenic Mice;voltage

PROJECT_TITLE: Voltage Imaging Analysis of Striatal Network Dynamics Related to Movement, Parkinson's Disease and Deep Brain Stimulation

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: ADELAIDE

ORG_NAME: UNIVERSITY OF SOUTH AUSTRALIA

PHR: Project Narrative Early diagnosis of FGR and the ability to predict abnormal fetal oxygenation later in gestation would improve outcomes for these babies not only during pregnancy and the neonatal period but also throughout life. Currently there are no methods for early second trimester diagnosis of placental dysfunction leading to poor fetal growth. Developing safe diagnostic tests of placental function as early in gestation as possible is therefore critical to improving population health.

PI_NAMEs: MORRISON, JANNA LEIGH (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Address;Adult;Affect;Animal Experimentation;Animals;Birth;Blood flow;Body Weight;Brain;Bronchopulmonary Dysplasia;cardiovascular disorder risk;Cardiovascular system;Cerebral Palsy;Cessation of life;Childhood;Clinical;Complex;consumption measures;Data;data analysis pipeline;Dedications;Development;Diagnosis;Diagnostic tests;Diffusion;Discipline of obstetrics;Early Diagnosis;early pregnancy;Face;fetal;fetal blood;fetal diagnosis;Fetal Growth;Fetal Growth Retardation;Fetal Monitoring;Fetus;Functional disorder;Future;Gene Expression;Genetic Markers;Goals;Growth;Housing;Human;Hypoxemia;Hypoxia;Iatrogenesis;Image;Imaging technology;Impaired cognition;improved;improved outcome;in utero;Injury;Intervention;late life;Late pregnancy;Life;Magnetic Resonance Imaging;Measurement;Measures;Metabolic Diseases;Methodology;Methods;Modeling;Molecular;molecular marker;Morbidity - disease rate;MRI Scans;neonatal outcome;neonatal period;non-genetic;novel;Nutrient;Operative Surgical Procedures;Organ;Outcome;Oxygen;Oxygen Consumption;Perfusion;Placenta;Placental Function Tests;Placental Insufficiency;Placentation;population health;Pre-Clinical Model;Predictive Value;Pregnancy;Pregnancy Complications;Premature Birth;protein biomarkers;protein expression;Regulation;response;Risk;Sampling;Scanning;Second Pregnancy Trimester;Secondary to;Sheep;Small for Gestational Age Infant;stillbirth;Syndrome;System;Technology;Testing;Third Pregnancy Trimester;Tissues;Ultrasonography;Uterus;Validation;vascular bed;Vascular resistance

PROJECT_TITLE: Predicting fetal growth early in pregnancy with non-invasive MRI: Validation in a preclinical model

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

PHR: Project Narrative Working memory and the ability to generate timed motor responses are essential for carrying out most daily tasks, and impaired in many neurological and psychiatric conditions. Yet, the brain regions, activity patterns, and learning rules that drive working memory and timing are not understood. Here we propose that the brain often multiplexes both forms of information, and we will use a novel behavioral task along with computational and experimental methods to test this hypothesis.

PI_NAMEs: BUONOMANO, DEAN V (contact);GOLSHANI, PEYMAN

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TITLE: Multiplexing working memory and timing: Encoding retrospective and prospective information in transient neural trajectories.


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative ! Converging lines of evidence provide compelling evidence that the functional domain of the cerebellum is not restricted to sensorimotor control, but extends to domains as diverse as perception, attention, language, and mathematics. To date, functional hypotheses have either been largely descriptive or targeted to account for cerebellar function in a relatively narrow, task-specific manner. The overarching goal of this research program is to take a more mechanistic approach, one designed to extend our understanding of cerebellar function across multiple task domains through the integrated use of behavioral and neuroimaging studies in healthy and neurologically impaired populations.

PI_NAMEs: IVRY, RICHARD  (contact)

PROJECT_TITLE: Human Cerebellar Function in Multiple Task Domains


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Infectious Diseases;Neurosciences;Sexually Transmitted Infections

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Alpha herpesviruses, like herpes simplex virus 1 (HSV-1), naturally infect the peripheral nervous system causing recurrent herpetic lesions, and can spread to the central nervous system causing encephalitis or may contribute to neurodegenerative disease. To spread to and within the nervous system, alpha herpesvirus particles must transport inside and then exit from infected cells, either non-neuronal cells, or neurons. The goal of this research is to better understand how HSV-1 spreads in the nervous system by investigating the molecular and cell biology of these processes.

PI_NAMEs: HOGUE, IAN B (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acute;Address;Agricultural Workers;Axon;Biological Models;Biological Process;Biology;Cell membrane;Cells;Cellular biology;Central Nervous System;Characteristics;China;Data;Development;Disease;Distal;druggable target;Encephalitis;Exhibits;Exocytosis;Family suidae;Fluorescence Microscopy;Focal Adhesions;gE protein;Genes;Goals;Golgi Apparatus;Herpesviridae;Herpesvirus 1;Human;human pathogen;Image;innovation;insight;Integration Host Factors;Intracellular Membranes;Intracellular Transport;Kinesin;knock-down;Knowledge;Lead;Lesion;live cell imaging;mad itch virus;Mediating;Methods;Microfluidics;Microtubule-Associated Protein 2;Microtubule-Associated Proteins;Microtubules;Modeling;Molecular;Molecular Biology;Motor;mutant;Mutation;Nervous System;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neuronal cell body;Neurons;neuropathology;particle;pathogen;Pathway interactions;Peripheral;Peripheral Nervous System;Pharmaceutical Preparations;Phenotype;Population;Process;Reagent;recruit;Recurrence;Reporting;Research;Role;Secretory Vesicles;Sensory;Site;Sorting;System;Tissues;trafficking;Vaccines;Vesicle;Viral;Viral Encephalitis;Viral Matrix Proteins;Viral Proteins;Virion;Virus;Zoonoses

PROJECT_TITLE: Molecular and cellular mechanisms of HSV-1 assembly and egress

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Although neuronal loss following brain injury is generally considered permanent, new neurons are born in select locations in the mammalian brain and then integrated into specific neural circuitry (i.e. neurons born in the subventricular zone and then guided by the rostral migratory stream to the olfactory bulb). We have created the first implantable engineered microtissue that structurally and functionally emulates the glial tube of the rostral migratory stream, to date being biofabricated from both rodent as well as human cell sources. The current proposal will evaluate the efficacy of this approach to redirect endogenous newborn neurons to sites of focal degeneration in a preclinical model of traumatic brain injury, which if successful, would provide a regenerative medicine strategy for neuronal replacement potentially capable of mitigating the often devastating — and currently untreatable — cognitive and motor deficits in afflicted patients.

PI_NAMEs: CULLEN, DANIEL KACY (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Acute;Address;Adult;Affect;Aging;Alzheimer's Disease;Anatomy;Area;Astrocytes;Autologous;Beds;Behavioral;biofabrication;Biomedical Engineering;Brain;Brain Injuries;cell type;Cells;Cerebral cortex;Chronic;Chronic Brain Injury;Chronic disability;Clinical;clinical translation;Cognitive deficits;controlled cortical impact;Corpus striatum structure;Cues;dentate gyrus;Dependence;design;Development;disability;efficacy evaluation;efficacy testing;Engineering;Exhibits;fabrication;Future;Gingiva;Harvest;Human;human stem cell-derived;Implant;improved;In Vitro;in vitro testing;in vivo;Injury;injury recovery;innovation;insight;Lateral;Lesion;Location;Mesenchymal Stem Cells;Methods;migration;minimally invasive;Morphology;motor deficit;multidisciplinary;Natural regeneration;Nerve Degeneration;Nerve Regeneration;nerve stem cell;Nervous System Trauma;neural circuit;neuroblast;Neurodegenerative Disorders;neurogenesis;neuron loss;neuronal replacement;Neurons;Neurosphere;newborn neuron;non-genetic;novel;Nude Rats;olfactory bulb;Parkinson Disease;Pathway interactions;Patients;Persons;Population;Positioning Attribute;Pre-Clinical Model;prevent;Prosencephalon;protein expression;Proteins;Publications;Punch Biopsy;Rattus;Recovery;Recovery of Function;Regenerative Medicine;repaired;Reproducibility;Residual state;Rodent;self assembly;Signal Transduction;Site;Source;Specialist;stem cell fate;stem cell migration;stem cells;Stream;Structure;subventricular zone;Target Populations;Techniques;Testing;Tissue Engineering;tissue stem cells;Tissues;translational approach;Traumatic Brain Injury;Traumatic Brain Injury recovery;Tube

PROJECT_TITLE: Tissue Engineered Rostral Migratory Stream for Directed Neuronal Replacement

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative A growing number of repeat expansion disorders have been shown to accumulate toxic repeat- associated non-ATG (RAN) proteins in patient neurological tissues. This proposal will characterize the accumulation of RAN proteins across multiple CAG·CTG repeat expansion disorders using novel repeat-specific antibodies. Additionally, we have designed AAV and small molecule approaches aimed at the protein kinase R (PKR) pathway to inhibit RAN translation. Using these tools we will test our central hypotheses that RAN protein pathology is a common feature shared across CAG·CTG expansion disorders and that inhibiting the protein kinase R pathway will reduce RAN protein levels and mitigate disease.

PI_NAMEs: BANEZ-CORONEL, MONICA ;RANUM, LAURA P.W (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: 3' Untranslated Regions;Affect;Antibodies;Ataxia;Autopsy;Bacterial Artificial Chromosomes;Behavioral;Brain;C-terminal;C9ORF72;CAG repeat;Categories;Cells;Collection;CRISPR/Cas technology;Cultured Cells;design;Development;Disease;Disease Progression;experimental study;FDA approved;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Genetic;genetic approach;Human;human disease;human tissue;Huntington Disease;improved;in vivo;Individual;induced pluripotent stem cell;inhibitor;insight;Introns;Knock-in Mouse;Length;LY6E gene;Metformin;MJD1 protein;Molecular;Mus;Mutation;Neurologic;Neurons;neuropathology;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Open Reading Frames;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;polyglutamine;Protein Biosynthesis;protein kinase R;Proteins;Reading Frames;RNA;Severity of illness;Site;small molecule;Spinocerebellar Ataxias;Testing;Therapeutic;Time;Tissues;tool;Toxic effect;Transcript;transcriptomics;Transgenic Organisms;Translations

PROJECT_TITLE: Contribution of RAN proteins to HD, SCA3 other CAG.CTG expansion diseases

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Narrative  We are proposing to develop an axon-specific bidirectional optical neural interface and test the system's efficacy to neuromodulate the parasympathetic nervous system by modulating heart function. We will use optogenetics and multiphoton optical excitation to simultaneously detect the neural activity and photostimulate individual axons from the exterior of the nerve i.e. an approach that is non-invasive yet has specificity. This technology has potential for major impact on the ability to treat many conditions; for example, vagal nerve stimulation in humans has been found to control epilepsy and depression, and evidence points to improvements in treatment of inflammatory bowel disease and Alzheimer's Disease.

PI_NAMEs: CALDWELL, JOHN H;GIBSON, EMILY ;WEIR, RICHARD FERGUS FFRENCH (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 3-Dimensional;Abdomen;Action Potentials;Afferent Neurons;Alzheimer's Disease;Anesthesia procedures;Animals;awake;Axon;Behavior;Behavioral;Biomedical Research;Brain;Breathing;Calcium;calcium indicator;Cardiac;Cardiology;Cells;Cervical;Chest;Chronic;Clinical;clinical application;Collaborations;Communication;conditioned fear;Development;Devices;disability;Disease;Efferent Neurons;Electrocardiogram;Electrodes;Engineering;Epilepsy;Fascicle;FDA approved;flexibility;Future;Generations;Genetic Vectors;Glass;Goals;Grant;Heart;heart function;heart imaging;Heart Rate;Human;human disease;Image;Implant;implantation;improved;in vivo;Individual;Inflammatory Bowel Diseases;Injections;innovation;Lasers;lens;Lung;Measurement;Mechanics;Mental Depression;Metabolic Diseases;Methods;Microscope;Miniaturization;miniaturize;minimally invasive;Monitor;mouse model;multi-photon;multiphoton microscopy;Mus;Needles;Nerve;Nerve Tissue;neural;Neurons;neuroregulation;Neurosciences;new technology;novel;Opsin;Optic Nerve;Optics;optogenetics;Organ;Parasympathetic Nervous System;Pathway interactions;Penetration;Peripheral;Peripheral Nerves;Peripheral Nervous System;pharmacologic;Pharmacologic Substance;Physiologic pulse;Physiological;Polymers;portability;Property;Proteins;prototype;Publications;Reporter;Research;Research Personnel;Resolution;Scanning;side effect;Signal Transduction;Source;Specificity;stressor;System;Systems Integration;Tail;Techniques;Technology;Testing;Transgenic Mice;translation to humans;translational potential;two-photon;United States National Institutes of Health;Vagus nerve structure;Veins;Viral;Viral Vector;virtual;Virus;voltage;Work

PROJECT_TITLE: Optimization of a Minimally-Invasive Bidirectional Optogenetic Peripheral Nerve Interface with Single Axon Read-in & Read-out Specificity


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Neurosciences;Rehabilitation

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Our movements are shaped by sensory information, and though much progress has been made in understanding how proprioceptors (muscle sensory neurons) shape motor function, much less is known about how touch receptors (skin sensory neurons) influence motor pathways. To generate a complete picture of how sensory information affects motor actions, this project incorporates a multidisciplinary approach to provide a functional roadmap of how skin touch receptors interact with spinal cord motor centers to shape movement. By understanding the final path for movement organization (i.e., the spinal cord) our research lays the critical foundation for novel ways to modulate spinal circuits for improving motor function affected by disease or injury.

PI_NAMEs: ABRAIRA, VICTORIA EUGENIA GUADALUPE (contact)

PROJECT_TERMS: Address;Affect;Afferent Neurons;Anatomy;Behavior;Behavioral Assay;behavioral study;Biological Assay;Biomedical Research;Complex;Computer Vision Systems;Coupled;Cutaneous;cutaneous sensory neurons;Data;Disease;electrical property;Electrophysiology (science);Environment;Extensor;Flexor;Foundations;Genetic;genetic approach;Hindlimb;improved;in vivo;Individual;Injury;insight;interdisciplinary approach;Interneurons;Investigation;Joints;Lateral;Length;Limb structure;Link;Locomotion;Machine Learning;Maps;Mechanics;Modality;Motor;Motor Activity;motor behavior;motor function improvement;Motor Neurons;Motor output;Motor Pathways;mouse genetics;Movement;multimodality;Muscle;Muscle Contraction;Nervous System Disorder;neural circuit;Neurons;Neurosciences;novel;novel strategies;novel therapeutics;Organ;Output;Parvalbumins;Pathway interactions;Pattern;Persons;Positioning Attribute;programs;Property;Proprioception;Proprioceptor;Quality of life;receptor;Reflex action;Research;Resolution;response;Sensorimotor functions;Sensory;sensory input;sensory stimulus;Shapes;Skin;Slice;somatosensory;Speed;Spinal;Spinal Cord;Spinal cord posterior horn;Structure;Synapses;Technology;Testing;tool;Touch sensation;vibration;Visualization;Walking;Work

PROJECT_TITLE: Touching on locomotion: an anatomical and functional analysis of spinal cord circuits that shape the way we move

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


NIH_SPENDING_CATS: Aging;Brain Disorders;Genetics;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The most common cause of idiopathic and familial Parkinson’s disease, an adult onset movement neurodegenerative disorder, are mutations in leucine-rich repeat kinase 2 (LRRK2). The overarching goal of this proposal is to understand the underlying mechanisms of mitochondrial DNA damage, a shared phenotype between LRRK2-associated and idiopathic PD. It is hoped that cellular pathways involved in maintaining mitochondrial genome integrity will reveal potential new therapeutic strategies to treat this devastating disease.

PI_NAMEs: SANDERS, LAURIE H (contact)

PROJECT_TERMS: Address;Adult;age related neurodegeneration;alpha synuclein;ataxia telangiectasia mutated protein;ATM activation;ATM function;Automobile Driving;Autopsy;Biochemical;Bioenergetics;Biological;brain tissue;Cell Death;Data;Defect;Dependence;Development;Disease;disease model;Disease Progression;DNA Damage;DNA lesion;DNA Repair;DNA Sequence Alteration;dopaminergic neuron;Dose;Etiology;Exposure to;Fibroblasts;Foundations;Functional disorder;Genetic;genome integrity;Goals;Health;Homeostasis;Human;human induced pluripotent stem cells;Idiopathic Parkinson Disease;Impairment;in vivo;induced pluripotent stem cell;insight;Investigation;kinase inhibitor;Knowledge;Link;LRRK2 gene;Mediating;member;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial genome;Modeling;Molecular;Movement;Movement Disorders;Mus;mutant;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neuroprotection;neurotoxic;novel;novel therapeutic intervention;Outcome;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Persons;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;Preclinical Testing;Proteins;Publishing;Reactive Oxygen Species;repaired;Reporting;response;Role;Signal Transduction;Techniques;Testing;Therapeutic;therapeutic target;toxicant;trafficking;Translating

PROJECT_TITLE: Mechanisms of mitochondrial genome integrity in familial and idiopathic Parkinson's disease


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Fibrosis is a common and debilitating physiological response to injury and inflammation in many tissues and organs, however very little is known about whether there is a fibrotic response to inflammatory diseases of the central nervous system (CNS) including multiple sclerosis, neuromyelitis optica, stroke, and CNS infections. We have identified that a robust fibrotic scar forms in response to CNS neuroinflammatory lesion formation and we will test the hypothesis that a fibrotic scar limits repair following neuroinflammatory disease. We will further examine the molecular mechanisms that lead to fibrotic scar formation, with the goal of identifying potential therapeutics to aid in repair following neuroinflammatory disease.

PI_NAMEs: DANEMAN, RICHARD  (contact)

PROJECT_TERMS: Ablation;Affect;Astrocytes;Automobile Driving;Cell Culture Techniques;Cell Proliferation;Cell secretion;Cells;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Cicatrix;Collagen;conditional knockout;Demyelinations;Deposition;Development;Disease;Event;Exclusion;Experimental Autoimmune Encephalomyelitis;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Fibrosis;Functional disorder;Ganciclovir;Goals;Heart;In Vitro;in vitro Model;in vivo;Inflammation;Inflammatory;injured;Injury;Kidney;Knockout Mice;Lead;Lesion;Liver;Lung;Mediating;Methods;migration;Modeling;Molecular;mouse model;Mouse Strains;Multiple Sclerosis;Mus;neuroinflammation;Neuromyelitis Optica;oligodendrocyte progenitor;Organ;Organ failure;Pathologic;Pathway interactions;Patients;PDGFRB gene;Pericytes;Physiological;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor alpha Receptor;precursor cell;prevent;Production;Proliferating;Recovery;Recovery of Function;recruit;repaired;reparative capacity;response;response to injury;Role;seal;Signal Pathway;Signal Transduction;single cell sequencing;Solid;Spinal cord injury;Stroke;Testing;Therapeutic;therapeutic target;Thymidine Kinase;Tissues;Transforming Growth Factor beta;Work

PROJECT_TITLE: How do CNS fibroblasts regulate the response to neuroinflammation?

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative This project will examine the mechanisms by which pupil-linked arousal modulates information processing in the brain. Dysregulation of the pupil-linked arousal system has been implicated in major clinical disorders, including schizophrenia, Parkinson’s disease, and depression, evidenced by abnormal pupil dynamics reported in individuals with the disorders. Therefore, the results of the proposed project will contribute to the knowledge base, potentially leading to more effective diagnosis and improved treatment of the disorders.

PI_NAMEs: WANG, QI  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Ablation;Acetylcholine;adeno-associated viral vector;Adrenergic Receptor;Affect;Afferent Neurons;Arousal;Attention;Attention deficit hyperactivity disorder;awake;barrel cortex;Behavior;behavior prediction;Behavioral;behavioral impairment;Behavioral Paradigm;Biosensor;Brain;Brain Diseases;Brain region;Brain Stem;Cerebral cortex;cholinergic;Cholinergic Receptors;Clinical;Code;Cognition;common symptom;Complex;cost;CRISPR/Cas technology;Detection;Development;Diagnosis;Disease;Electrophysiology (science);experimental study;Genetic;genetic manipulation;Goals;Guide RNA;Head;Health;improved;indexing;Individual;information processing;insight;Knock-out;Knowledge;knowledge base;Lighting;Link;locus ceruleus structure;Maps;Measures;Mediating;Mental Depression;Mental disorders;Molecular;Mus;Mydriasis;Nervous System Disorder;neural;Neurons;neuropsychiatric disorder;neuroregulation;noradrenergic;Norepinephrine;norepinephrine system;novel;Outcome;Parkinson Disease;Perception;Performance;Persons;Play;Property;Psyche structure;Psychometrics;Pupil;receptor;Reporting;response;Role;Schizophrenia;sensor;Sensory;Short-Term Memory;Signal Transduction;Stimulus;System;Tactile;Technology;Testing;Thalamic structure;tool;translational impact;Vibrissae;Work

PROJECT_TITLE: Noradrenergic and Cholinergic Mechanisms Underlying Pupil-linked Arousal Modulation of Thalamic Sensory Processing

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Immunotherapy;Muscular Dystrophy;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The current study promises to transform the field by defining how regulatory T cells (Treg) suppress a novel macrophage and stromal cell interaction that promotes muscle fibrosis during Duchenne muscular dystrophy (DMD). Our research has great potential to reveal new targets and innovative therapeutic strategies that inhibit fibrogenic inflammatory responses in DMD.

PI_NAMEs: VILLALTA, SERGIO ARMANDO (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Ablation;Acute;Address;Antibodies;Antibody Therapy;Biological Assay;Cell Communication;Cells;Chronic;Clinical;Complex;Data;Deposition;Development;Disease;Disease Progression;Duchenne muscular dystrophy;Extracellular Matrix;Fibrosis;Foundations;Galectin 3;Gene Expression Profile;Genes;Goals;Histologic;Immune;immune cell infiltrate;Immune system;Immunogenetics;immunoregulation;Immunosuppression;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;innovative technologies;insight;Interferon Type II;Interleukin-10;Interleukin-2;Investigational Therapies;Lymphoid;Macrophage;mdx mouse;Mediating;Mediator;Molecular;Mus;Muscle;muscle degeneration;muscle regeneration;Muscular Dystrophies;Myelogenous;Natural regeneration;novel;novel strategies;osteopontin;Outcome;Outcome Study;Pathogenesis;Pathologic Processes;Pathway interactions;pharmacologic;Population;Process;Production;Regulatory T-Lymphocyte;Reporting;Research;response;Role;Severities;Severity of illness;Signal Transduction;single-cell RNA sequencing;stem;Stromal Cells;System;Testing;Therapeutic;Time

PROJECT_TITLE: Novel macrophage and regulatory T cell interactions that promote the pathogenesis of Duchenne muscular dystrophy

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]