NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Unintentional Childhood Injury

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE Parent-engagement strategies, while effective in reducing teen motor vehicle collisions (MVCs), have not been implemented and tested among high-risk teen drivers such as those with a traffic violation. Through established collaborations with rural and urban juvenile traffic courts in Ohio, this study will test, in a hybrid randomized controlled trial, the implementation, effectiveness, and cost-effectiveness of a parent- engagement intervention tailored to the needs of teen drivers with a traffic violation. The findings will have an impact on juvenile traffic courts’ practices and policies aimed to improve teen driving safety by reducing MVCs and MVC-related injuries and deaths, which aligns with NICHD’s ongoing research priority.

PI_NAMEs: YANG, JINGZHEN GINGER (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Address;Adolescent;Adopted;Adoption;Age;Agreement;Area;arm;Automobile Driving;Cause of Death;Cessation of life;Collaborations;Communication;Consolidated Framework for Implementation Research;contextual factors;Control Groups;Cost Analysis;cost effective;cost effective intervention;cost effectiveness;County;court;distracted driving;driving behavior;driving safety;effective intervention;effectiveness evaluation;Effectiveness of Interventions;effectiveness-implementation RCT;Enrollment;Evaluation;evidence base;Evidence based program;Failure;Feedback;Goals;group intervention;Hearing;high risk;high risk population;Hybrids;implementation intervention;implementation research;implementation science;improved;Injury;innovation;Intervention;intervention delivery;Interview;Laws;Legal Guardians;Letters;Licensing;Methods;multidisciplinary;National Institute of Child Health and Human Development;Ohio;Outcome;Outcome Study;parenting intervention;Parents;peer;Pilot Projects;Policies;Population;Process;Program Sustainability;programs;Protocols documentation;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recidivism;recruit;Research;Research Priority;Risk;risky driving;Rural;rural setting;Safety;Seat Belts;skills;Specialist;Speed;Technology;teen drivers;teen driving;Teenagers;Testing;Training;Translating;United States;universal prevention;Urban Population;urban setting;Vehicle crash

PROJECT_TITLE: Adoption and Implementation of an Evidence-based Safe Driving Program for High-Risk Teen Drivers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DIRH-N(09)]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Sleep Research

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PI_NAMEs: FUNG, LAWRENCE  (contact)

PROJECT_TERMS: Area;autism spectrum disorder;autistic children;Behavioral Sciences;career development;Caregivers;Caring;Characteristics;Clinical;clinical development;Collaborations;Communication;Communities;community academic partnership;community based participatory research;Community Outreach;design;Development;Educational process of instructing;Environment;Evidence based practice;experience;Faculty;Family;Family member;Fellowship;graduate student;individuals with autism spectrum disorder;Infrastructure;Journals;Knowledge;Manuscripts;medical schools;meetings;Mentorship;Methods;Newsletter;next generation;outreach;Parents;Patients;Pediatric Hospitals;Peer Review;Postdoctoral Fellow;postdoctoral investigator;pre-doctoral;predoctoral investigator;programs;Provider;Psychiatry;Publications;Research;research and development;Research Personnel;Research Training;Resources;Sleep;Sleep Deprivation;Students;symposium;Thinking;Training;Training Programs;undergraduate student;Universities;web site;working group

PROJECT_TITLE: Dissemination and Outreach Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-T]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE  This proposal seeks to further develop and validate a cell-size-based MR imaging method dubbed MRI-cytometry as a novel approach for imaging tumor-infiltrating lymphocytes in tumors, and to evaluate its performance as a surrogate imaging biomarker to predict treatment response to immune-checkpoint blockade immunotherapy.

PI_NAMEs: XU, JUNZHONG  (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Address;androgen independent prostate cancer;Animal Model;cancer cell;cancer imaging;Cancer Patient;Cell Fraction;Cell Size;Cells;Clinic;Clinical;Clinical Treatment;Clinical Trials;Combined Modality Therapy;Complex;conventional therapy;cost;Cytometry;Data;Development;Diameter;Diffusion;Eligibility Determination;Evaluation;Histology;Image;Image Cytometry;imaging approach;imaging biomarker;Imaging Device;imaging modality;immune checkpoint blockade;Immunohistochemistry;Immunotherapy;improved;in vivo;Infiltration;Injections;Label;Lymphocyte;Lymphocytic Infiltrate;Magnetic Resonance Imaging;Mainstreaming;Malignant Neoplasms;Measures;meter;Methods;Modeling;nanoparticle;novel;novel strategies;Patients;Performance;personalized medicine;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;Prediction of Response to Therapy;prevent;Property;Protocols documentation;Radiation therapy;Relaxation;Reporting;responders and non-responders;response;Risk;single photon emission computed tomography;Slide;Spectrum Analysis;T-Lymphocyte;Testing;Toxic effect;Translating;treatment planning;treatment response;tumor;tumor progression;Tumor Volume;Tumor-Infiltrating Lymphocytes;Validation;Water

PROJECT_TITLE: MRI of tumor-infiltrating lymphocytes using MRI-cytometry

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Sleep Research

PI_NAMEs: HALLMAYER, JOACHIM F (contact)

PROJECT_TERMS: adolescent with autism spectrum disorder;Affect;animal data;ASD patient;Attention;Autism diagnostic;autism diagnostic observation schedule;autism spectrum disorder;autistic children;Behavior;Behavior assessment;Behavioral;Behavioral Symptoms;Brain;Caregivers;Child;Child Behavior Checklist;Clinical;Clinical assessments;Cognitive;cognitive testing;cohort;common symptom;comorbidity;Consensus;Consent;Data;Data Analytics;data exchange;data management;Development;Diagnostic;Dimensions;Disease;Enrollment;Ensure;Epidemiology;experience;Family;Family history of;Foundations;Functional disorder;gene function;Genes;Genetic study;Goals;Interview;Learning;Link;Medical;Medical History;Mission;Mutation;Neurobehavioral Manifestations;Neuronal Plasticity;Neurons;non rapid eye movement;Parents;Participant;participant enrollment;Pathogenesis;Pathway interactions;Physical Examination;Procedures;psychosocial;Questionnaires;recruit;repetitive behavior;Resources;Role;Sampling;Schedule;Sensory;Services;Sleep;sleep abnormalities;sleep behavior;Sleep disturbances;sleep onset;sleep quantity;Sleeplessness;social;social communication;Structure;success;Symptoms;Synapses;Synaptic plasticity;Training

PROJECT_TITLE: Recruitment and Clinical Assessment Core


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Sleep Research

PI_NAMEs: JO, BOOIL  (contact)

PROJECT_TERMS: actigraphy;adolescent with autism spectrum disorder;Age;aged;Animal Genetics;Animal Model;autism spectrum disorder;autism symptoms;autistic children;awake;Behavior;Behavioral;Behavioral Symptoms;Biological;Calibration;Chick;circadian;Clinical;Cognition;Cognitive;cognitive function;Collection;comparative;Comparative Biology;Data;Data Analyses;Data Analytics;data integration;data management;Data Set;data visualization;design;Development;Diphenhydramine;Double-Blind Method;Electroencephalography;Electrophysiology (science);Ensure;Experimental Animal Model;Gender;Genetic Diseases;Genetic Models;Heterogeneity;Human;Impairment;improved;Leadership;Maintenance;Measures;model of autism spectrum disorder;Modeling;mouse model;multimodal data;multimodality;Mus;Neurobehavioral Manifestations;Noise;Participant;Pharmaceutical Preparations;Phenotype;Placebo Control;Polysomnography;programs;Quality Control;Randomized;repetitive behavior;Reproducibility;Research Personnel;response;Rest;Role;Secure;Sleep;Sleep Architecture;Sleep Fragmentations;sleep physiology;social communication;Source;Statistical Data Interpretation;Statistical Methods;Structure;Symptoms;System;Validation;Variant;Zebrafish;zolpidem

PROJECT_TITLE: Data Management and Analysis Core


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infant Mortality;Lung;Neonatal Respiratory Distress;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse

ORG_CITY: BIRMINGHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative  Many infants exposed to opioids before birth due to use of these drugs by the mother develop Neonatal Opioid Withdrawal Syndrome (NOWS). In this project, our center (the Regional Neonatal ICU at the University of Alabama at Birmingham) will join other centers in doing a clinical trial on infants to identify the best medicines that can be used to treat infants who develop Neonatal Opioid Withdrawal Syndrome. Our center has much experience in participating in similar multicenter studies, and will be able to enroll many newborn infants with opioid withdrawal.

PI_NAMEs: AMBALAVANAN, NAMASIVAYAM  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: 2 year old;addiction;Admission activity;Alabama;antenatal;Award;Birth;Birth Weight;Budesonide;Buprenorphine;Certification;Clinical;clinical application;clinical center;Clinical Practice Guideline;Clinical Research;clinical research site;Clinical Trials;Clonidine;cohort;Collaborations;comparative effectiveness;comparative effectiveness trial;Data;design;Diagnosis;Discipline of obstetrics;Drug usage;effectiveness clinical trial;Enrollment;Ethnic Population;evidence base;experience;Exposure to;follow-up;Funding;Gestational Age;Goals;Helping to End Addiction Long-term;high risk infant;Hospitals;in utero;Infant;Infant Care;Longitudinal Studies;Measures;Medicine;Methadone;Morphine;Mothers;Multicenter Neonatal Research Network;Multicenter Studies;Multicenter Trials;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;Neonatal;Neonatal Abstinence Syndrome;Neonatal Intensive Care Units;neurodevelopment;Newborn Infant;Opioid;opioid exposure;opioid use;opioid withdrawal;Outcome;participant retention;patient population;payment;Perinatal;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacy facility;Phenobarbital;Pregnancy;prevent;Productivity;programs;Protocols documentation;racial population;Randomized, Controlled Trials;recruit;Regimen;Research;response;Site;social;socioeconomics;Training;United States National Institutes of Health;Universities;Variant;Weaning;Work

PROJECT_TITLE: UAB Clinical Site HEAL Neonatal Opioid Withdrawal Pharmacological Treatments


PI_NAMEs: O'HARA, RUTH M (contact)

PROJECT_TERMS: actigraphy;Address;Adolescent;Age;Animal Experiments;Animal Model;Animals;autism spectrum disorder;autism symptoms;autistic children;awake;Behavior;behavior measurement;Brain;Caregivers;Child;Circadian Rhythms;Cognition;Cognitive;cognitive function;Collaborations;Communication difficulty;Data;density;Development;Electroencephalography;Electrophysiology (science);Etiology;Exhibits;experience;Frequencies;frontal lobe;Gender;Genetic Models;gray matter;Home;Home environment;Human;Impairment;improved;individuals with autism spectrum disorder;Investigation;Knock-out;Knockout Mice;Laboratories;Link;Measures;Meta-Analysis;model of autism spectrum disorder;myelination;neurodevelopment;Neurons;Parents;Participant;Pathology;Pattern;Physiology;Pilot Projects;Polysomnography;Rattus;REM Sleep;repetitive behavior;Reporting;Rest;Sample Size;Sampling;Severities;sex;Sleep;Sleep Architecture;Sleep Deprivation;Sleep disturbances;Sleep Fragmentations;sleep onset;sleep quality;Slow-Wave Sleep;social;social cognition;social communication;Stereotyped Behavior;Symptoms;Synapses;Synaptic plasticity;Testing;trait;Wakefulness

PROJECT_TITLE: Project 1: The impact of sleep dysregulations on Autism Spectrum Disorder


ADMINISTERING_IC: AG

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: FORT WORTH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: HABS-HD OVERALL SUMMARY By 2060 the U.S. will become largely “non-white” with 15% of the population being African American and 27.5% being Hispanic (65% of which are Mexican American). African Americans currently have the highest burden of Alzheimer’s Disease (AD) while Hispanics will experience the greatest increase in AD by 2060; however, our understanding of the factors that contribute to these health disparities remains very limited. HABS-HD is conducting the first-ever comprehensive simultaneous study of the biological, medical, environmental and social factors, all within a health disparities framework, to understand the factors that contribute to AD risk over adulthood across the three largest racial/ethnic groups in the U.S.

PI_NAMEs: JOHNSON, LEIGH A;O'BRYANT, SID E (contact);RISSMAN, ROBERT ;TOGA, ARTHUR W;YAFFE, KRISTINE

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Aducanumab;Adult;Affect;African American;African American population;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Area;Biological;Biological Markers;Biostatistics Core;Blood;Blood Vessels;Clinic;Clinical;Clinical Trials;cohort;Communities;Data;Data Analyses;deprivation;Development;Disparity;Enrollment;Ensure;Environmental Risk Factor;Ethnic Origin;Ethnic Population;Etiology;exosome;experience;Genetic;Genome;genomic data;Goals;Guidelines;Health;Health Disparities Research;health disparity;health goals;Hispanic;Hispanic Populations;Image;indexing;Individual;Inflammatory;Informatics;Life Cycle Stages;Liquid substance;Longitudinal cohort;Magnetic Resonance Imaging;Medical;Metabolic;metabolome;Methods;Mexican Americans;neighborhood disadvantage;neuroimaging;Neuropsychology;next generation;Not Hispanic or Latino;novel;novel strategies;outreach;Participant;Pathway interactions;Pharmaceutical Preparations;Population;Population Heterogeneity;Positron-Emission Tomography;precision medicine;Prevention strategy;programs;Proteome;Race;racial population;recruit;Research;Sampling;Science;Scientist;social culture;social factors;sociocultural determinant;Structure;tau Proteins;Therapeutic;Training;treatment strategy;United States National Institutes of Health;Visit

PROJECT_TITLE: The Health & Aging Brain Study - Health Disparities (HABS-HD)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: O'BRYANT, SID E (contact)

PROJECT_TERMS: Address;Adult;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Biological Markers;Biometry;Biostatistics Core;Clinic;Clinical;Collaborations;Collection;Communication;Communities;Data;data access;data access system;Data Collection;data dissemination;data portal;data quality;Decision Making;Development;Disparity;Effectiveness;Ensure;Ethnic Origin;Ethnic Population;Goals;Health;Health Disparities Research;health disparity;health goals;Informatics;Institution;Institutional Review Boards;interest;Leadership;Literature;meetings;Methods;Mission;Monitor;neuroimaging;Not Hispanic or Latino;outreach;Participant;Patient Recruitments;Pharmaceutical Preparations;Policies;Population Heterogeneity;Positron-Emission Tomography;Principal Investigator;Procedures;programs;Protocols documentation;Publications;Quality Control;Race;racial population;Recommendation;Reporting;Research;Research Personnel;Resources;Science;Scientific Advances and Accomplishments;Series;Structure;tau Proteins;Tracer;Work

PROJECT_TITLE: HABS-HD - Core A - Admin Core


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Sleep Research

PI_NAMEs: HARDAN, ANTONIO  (contact)

PROJECT_TERMS: actigraphy;Adolescent;adolescent with autism spectrum disorder;Affect;Age;aged;Aggressive behavior;Agonist;Animals;antagonist;Anxiety;associated symptom;Attention;autism spectrum disorder;autism symptoms;autistic children;Behavior;Behavioral;Biological;Caregivers;Child;Circadian Rhythms;Clinical;design;developmental disease;Diphenhydramine;Double-Blind Method;Drowsiness;drug action;effectiveness evaluation;Equilibrium;gamma-Aminobutyric Acid;Goals;Histamine;Histamine Agents;Human;Hydrocortisone;Hyperactivity;hypnotic;hypocretin;Impaired cognition;improvement on sleep;inattention;individuals with autism spectrum disorder;interest;Investigation;Learning;Link;Maintenance;Measures;Melatonin;memory consolidation;Moods;neurobiological mechanism;Neurobiology;Neurodevelopmental Disorder;Neurotransmitters;non rapid eye movement;Parents;peer;Pharmaceutical Preparations;pharmacologic;Phase;Pilot Projects;pilot trial;Placebo Control;Placebos;Play;Polysomnography;Prevalence;Property;Questionnaires;Randomized;receptor;recruit;REM Sleep;repetitive behavior;Reporting;Research;Role;Saliva;sedative;Sensory;Series;Severities;Sleep;sleep abnormalities;Sleep Architecture;sleep behavior;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;Sleep Initiation and Maintenance Disorders;sleep onset;sleep physiology;sleep quality;Slow-Wave Sleep;social communication;Symptoms;Synapses;Synaptic plasticity;Testing;therapy development;Time;Wakefulness;Youth;zolpidem

PROJECT_TITLE: Project 2: Pharmacological Probing of Sleep Physiology in Autism


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Human Genome;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative This proposal seeks to investigate the ethical, social, and policy implications of a new kind of genetic information currently available to the public: polygenic scores for educational attainment (EA-PGS). The proposal includes a research plan to 1) qualitatively investigate individuals who have received EA-PGS results via direct-to-consumer (DTC) genetic testing, 2) quantitatively investigate how exposure to EA-PGS research in popular media influences attitudes about educational disparities in the US, and 3) develop an ethical framework on the potential harms and benefits of EA-PGS. The proposal includes a career development plan for the PI to complete training and coursework in qualitative methods, quantitative methods, and bioethics.

PI_NAMEs: MATTHEWS, LUCAS JOHN (contact)

PROGRAM_OFFICER_NAME: STERLING, RENE

PROJECT_TERMS: Address;Alzheimer's disease risk;Attitude;Behavior;Behavioral Genetics;behavioral outcome;Belief;biobank;Bioethics;Birth;Blood specimen;Cardiovascular Diseases;career;career development;Caring;Child;Complex;Consultations;coping;Data;design;Development;Development Plans;Diabetes Mellitus;Disclosure;Disease;Disparity;DNA;Dyslexia;Education;education access;Empirical Research;Environmental Risk Factor;ethical, legal, and social implication;Ethics;ethnic disparity;exercise capacity;experience;Exposure to;Funding;General Population;Genetic;genetic information;genetic predictors;Genetic Predisposition to Disease;Genetic Risk;genetic testing;genetic variant;Genome;Genomics;Goals;Health;Household;Human;Human Genetics;improved;Income;Individual;intelligence genetics;interest;Intervention;Interview;Investigation;Mainstreaming;Malignant Breast Neoplasm;mathematical ability;Mediating;Medical;Medicine;Mental Depression;Mentors;Methods;Outcome;Parents;Patients;Performance;Persons;Philosophy;Policies;policy implication;precision medicine;psychosocial;public database;Qualitative Methods;Qualitative Research;Race;racial difference;racial disparity;Randomized;Reading;reading ability;Recommendation;Recording of previous events;Research;Research Personnel;Research Proposals;Risk;Saliva;Scholarship;Schools;Science;Scientist;skills;smartphone application;social;social implication;social influence;Students;Sum;Surveys;Symptoms;Techniques;Testing;Traction;Training;trait;United States National Institutes of Health;Universities;web site

PROJECT_TITLE: The Geneticization of Education: ethical, social, and policy implications of polygenic scores for educational attainment


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: aging brain;Alzheimer's Disease;Amyloid;Atherosclerosis;Authorization documentation;Biological Markers;Biostatistics Core;Blood Vessels;Brain;Cerebrovascular Circulation;Clinical;Clinical Data;Collaborations;Collection;Communities;Computers;Custom;Data;data acquisition;Data Analyses;data analysis pipeline;Data Collection;data dissemination;data management;Databases;Dementia;Diffusion Magnetic Resonance Imaging;Documentation;electronic data;electronic data capture system;Ensure;Environment;Ethnic Population;experience;Generations;Genetic;Goals;Health;health application;health disparity;Health Sciences;Hemorrhage;Hippocampus;Image;imaging facilities;imaging modality;improved;Informatics;Information Systems;Infrastructure;Laboratories;Leadership;Liquid substance;Magnetic Resonance Imaging;Measures;Methods;MRI Scans;multi-site trial;multimodality;Nerve Degeneration;neuroimaging;Neuropsychology;Noise;open data;Parkinson Disease;Participant;Patients;Phase;Policies;Population;Positron-Emission Tomography;Process;programs;progression marker;Protocols documentation;Publications;Qualifying;Quality Control;racial population;Research;Research Personnel;Resolution;Risk;Role;Scanning;Schedule;Scientist;Services;Site;Slice;Support System;tau Proteins;Texas;tool;Translational Research;Universities;user-friendly;web site;White Matter Hyperintensity;Work

PROJECT_TITLE: HABS-HD - Core B - Neuroimaging & Informatics Core


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Sleep Research

PI_NAMEs: MOURRAIN, PHILIPPE  (contact)

PROJECT_TERMS: Agonist;Animal Model;antagonist;Antihistamines;ASD patient;autism spectrum disorder;autism symptoms;Behavior;Behavioral;behavioral deficiency;Brain;Brain region;Brain Stem;Cardiovascular system;Cell Nucleus;Cells;Central Nervous System;Chimeric Proteins;circadian;Coin;Coupled;Data;Defect;density;Development;Developmental Biology;DLG4 gene;Etiology;Eye Movements;Fishes;Fluorescence;Fragile X Syndrome;Future;gamma-Aminobutyric Acid;Genetic;Genotype;gephyrin;Goals;Heart Rate;Human;Hyperactivity;hypnotic;hypocretin;Hypothalamic structure;imaging approach;Impairment;improved;improvement on sleep;Intervention;Investigation;Knock-out;Maintenance;Mammals;Melatonin;Methods;Modeling;Motor Activity;Mus;Muscle;Muscle Tonus;mutant;Nervous System;neural;Neurons;non rapid eye movement;novel;olfactory bulb;Optics;Pattern;pharmacologic;Physiological;Polysomnography;pressure;prevent;Proteins;Pyrilamine;receptor;repetitive behavior;Resolution;risk variant;Role;Schools;serial imaging;Siblings;Skeletal Muscle;Sleep;sleep abnormalities;Sleep disturbances;sleep onset;Sleep Wake Cycle;Slow-Wave Sleep;social;Social Behavior;Social Interaction;Spinal Cord;Swimming;Synapses;Synaptophysin;Testing;Time;tool;whole body imaging;Zebrafish;zolpidem

PROJECT_TITLE: Project 4: Whole-brain and body characterization of sleep disturbances and interventions in Fmr1, Shank3 and Cntnap2 knockout zebrafish


ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The goal of this SPORE is to develop and test novel therapeutic strategies for the treatment of pancreas ductal adenocarcinoma (PDAC), with the ultimate goal of improving survival. The SPORE team will recruit and train new investigators and build resources to be shared with the PDAC research community.

PI_NAMEs: DENARDO, DAVID G (contact);HAWKINS, WILLIAM G;LIM, KIAN H

PROGRAM_OFFICER_NAME: UJHAZY, PETER

PROJECT_TERMS: Agonist;Basic Science;bench-to-bedside translation;Bioinformatics;Biometry;California;Cancer Biology;Cancer Center;cancer genomics;Cancer Research Project;cancer type;career;Clinic;Clinical;clinical care;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;design;Development;Diagnosis;Disease;drug development;Drug resistance;Ensure;Environment;Ethics;Faculty;Fostering;Funding;gastrointestinal;Genomics;Goals;Image;immune resistance;Immunologics;Immunology;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;Individual;Infrastructure;innovation;Institution;inter-institutional;ITGAM gene;Leadership;leukemia;Malignant neoplasm of pancreas;Malignant Neoplasms;medical schools;Mentors;Metabolic;Minority;Mission;multidisciplinary;Nebraska;neoantigen vaccine;North Carolina;novel;novel diagnostics;novel strategies;novel therapeutic intervention;Pancreatic Ductal Adenocarcinoma;Patient Participation;patient population;Patient-Focused Outcomes;Patients;Pennsylvania;programs;Quality of life;recruit;Research;Research Personnel;Research Project Grants;resistance mechanism;Resource Sharing;Resources;Specialized Program of Research Excellence;Stress;Testing;Therapeutic Clinical Trial;Therapeutic Trials;Training;translational applications;translational cancer research;translational impact;translational potential;Translational Research;Translations;treatment strategy;Universities;Washington

PROJECT_TITLE: Washington University SPORE in Pancreatic Cancer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Adherence;Adult;African American;African American population;Age;aging brain;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Ancillary Study;Back;Behavioral;biobank;Biological Markers;Blood specimen;Brain;Cataloging;Cerebrospinal Fluid;Clinical;Clinical Data;clinical diagnosis;Cognitive;cohort;Collaborations;Collection;Communities;community collaboration;Community Relations;Consensus;Consent;Data;Data Collection;Diagnosis;Disparity;Educational Materials;electronic data capture system;Enrollment;Ensure;Ethnic Population;Family;Feedback;Focus Groups;Foundations;future implementation;Goals;Health;Health Disparities Research;health disparity;health goals;Health Personnel;Image;informant;Informatics;Informed Consent;Infrastructure;Interview;Letters;Licensing;Magnetic Resonance Imaging;Measures;Medical;Mexican Americans;Modeling;Monitor;Multicultural Education;neuroimaging;Neuropsychology;Not Hispanic or Latino;novel;outreach;Parents;Participant;participant interview;Persons;Population;Positron-Emission Tomography;precision medicine;Prevention strategy;Printing;Procedures;Process;programs;Protocols documentation;racial population;Real-Time Systems;recruit;Research;Sampling;social culture;Spinal Puncture;Standardization;Time;treatment strategy;Update;virtual;Visit;web site;Work

PROJECT_TITLE: HABS-HD - Core C - Clinical Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE This shared resource will provide administrative support necessary for the translational pancreatic cancer research proposed in this SPORE and will facilitate collaboration between other SPORE institutions.

PI_NAMEs: HAWKINS, WILLIAM G (contact)

PROJECT_TERMS: Address;Advocacy;Animals;anti-cancer research;Bioinformatics;Biometry;career;Clinical Services;Clinical Trials;Collaborations;Communication;Community Health Education;Community Outreach;Contracts;Dedications;Development;Disparity;Documentation;Ensure;Faculty;Feedback;Funding;Grant;Group Meetings;Guidelines;Human;Institution;Leadership;Malignant neoplasm of pancreas;Manuscripts;meetings;member;Minority Participation;Minority Recruitment;Monitor;National Cancer Institute;Participant;Patient advocacy;Patients;peer;Peer Review;programs;Progress Reports;Protocols documentation;Publications;PubMed;Research;Research Personnel;Resource Sharing;Resources;Sampling;Travel;Underrepresented Minority;Universities;Update;Washington;web site;working group

PROJECT_TITLE: Core A: Administrative Core


ADMINISTERING_IC: HS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE Smartphone-based education and remote self-monitoring are scalable solutions that can address unmet information needs and address poor care coordination, anxiety, and caregiver burden among older adults transitioning home after major surgery. This proposal outlines the development and refinement of the myPOSH intervention, a digital health solution to support the needs of older adults undergoing major surgery and their care-partners. The findings from this work can be scaled and spread to increase the value of care provided for a variety of health conditions and will drive future efforts to improve transitions home after major surgery.

PI_NAMEs: BITTON, ASAF  (contact);BRINDLE, MARY ELIZABETH

PROGRAM_OFFICER_NAME: CHANEY, KEVIN

PROJECT_TITLE: Scalable Digital Communication Intervention to Support Older Adults and Care-partners Transitioning Home After Major Surgery

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: JOHNSON, LEIGH A (contact)

PROJECT_TERMS: African American population;aging brain;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;biobank;Bioinformatics;Biological Assay;Biological Markers;biomarker validation;Biostatistics Core;Blood;clinical diagnosis;Clinical Trials;cohort;Collaborations;Collection;Data;Data Analyses;Data Set;Dementia;Diagnostic;Disease;Ethnic Population;exosome;Fatty Acids;follow-up;genome repository;genome sequencing;genome wide association study;genomic data;Glycolysis;Health;health disparity;Impaired cognition;International;Investigation;lipid metabolism;Marker Discovery;Mass Spectrum Analysis;metabolomics;Methods;Methylation;Mexican Americans;mild cognitive impairment;Modeling;Molecular Weight;Nerve Degeneration;Neurons;Not Hispanic or Latino;novel;novel marker;oxidation;Oxidative Phosphorylation;Participant;Pathology;Pathway interactions;Pharmaceutical Preparations;Plasma;Population;Population Heterogeneity;Prognosis;Proteins;Proteomics;Protocols documentation;Publishing;Qualifying;Quality Control;racial population;Research Personnel;Sampling;System;tau Proteins;Technology;transcriptomics;Update;Validation;Visit;whole genome;Work

PROJECT_TITLE: HABS-HD - Core D - Omics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Address;African American;African American population;Age;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Awareness;Back;Biological Markers;Brain;Clinical;Cognitive aging;cohort;Collaborations;Communities;community advisory board;community engagement;Community Networks;Community Outreach;Data;Development;Disparate;Disparity;Education;Education and Outreach;Educational Materials;Ensure;ethnic minority population;Ethnic Population;Event;Feedback;Focus Groups;Funding;Future;Goals;Health;Health Disparities Research;health disparity;health goals;Hispanic Populations;Home;improved outcome;Individual;Informatics;information gathering;Infrastructure;Institution;Life Cycle Stages;Linguistics;Location;Measures;member;Methods;Mexican Americans;Minority Groups;Monitor;multi-ethnic;neuroimaging;Newsletter;Not Hispanic or Latino;novel;outreach;Participant;Population;Population Heterogeneity;precision medicine;Prevention strategy;Procedures;Process;Protocols documentation;Publications;Race;racial minority population;racial population;recruit;Research;Research Methodology;Scientist;social media;Spinal Puncture;Students;Training;treatment strategy;Underrepresented Minority;Work

PROJECT_TITLE: HABS-HD - Core E - Disparities & Outreach Core


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: Regular physical activity is associated with reduced risk of several diseases important to Veterans, including cardiovascular disease and diabetes, and is associated with better mental health. Walking is a safe and effective way to get the recommended amount of physical activity. Unfortunately, more than 1 in 3 Veterans over age 45 meet the definition of physically inactive. Behavioral economics suggests that our inability to start and stick to an exercise routine may be the result of “present bias,” which is a tendency to value the immediate reward of remaining sedentary over large rewards of long-run physical activity. Patient incentives may overcome present bias by moving the rewards for healthy behaviors forward in time. In the proposed study we will determine the optimal design for an incentive program that gives Veterans tangible, timely rewards for walking a target average number of steps per day. If effective, an incentive program may be an economical way to improve Veterans’ physical and mental health without taxing the healthcare delivery system.

PI_NAMEs: HEBERT, PAUL L. (contact)

PROJECT_TERMS: Accelerometer;active lifestyle;Address;Adult;Age;Area;Award;Behavior;behavior change;behavioral economics;Cardiovascular Diseases;Chronic;Complex;cost;Cost Analysis;design;Diabetes Mellitus;Disease;Distant;Dose;education research;Educational Status;Employee;Enrollment;Exercise;exercise regimen;Female;fitbit;Frequencies;Future;Gender;Goals;Grant;Guidelines;Habits;Health;Health behavior change;health care delivery;health goals;healthy aging;Heart Diseases;improved;incentive program;Incentives;Income;innovation;Institution;Internet;Intervention;Interview;Knowledge;Low income;Maintenance;male;Mental Depression;Mental Health;Methodology;military veteran;Moderate Exercise;mortality;multiphase optimization strategy;Non-Insulin-Dependent Diabetes Mellitus;novel;Participant;Patients;payment;Persons;PF4 Gene;Phase;Physical activity;physical conditioning;physical inactivity;Population;prevent;primary outcome;Probability;randomized trial;Recommendation;Reporting;Research;Research Design;Rewards;Risk;Running;satisfaction;screening;sedentary;sedentary activity;System;Taxes;Testing;theories;therapy design;Time;treatment as usual;tv watching;United States;United States Department of Veterans Affairs;usual care arm;Veterans;Walking;Work

PROJECT_TITLE: Multiphase Optimization Trial of Incentives for Veterans to Encourage Walking

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Periviable birth is among the leading causes of infant death and childhood disability, with disproportionate impact in low-income and minority communities, and although relatively rare, the CDC estimates that extremely premature deliveries result in societal costs exceeding $26 billion dollars annually. To optimize high-stakes periviable counseling encounters, we propose to test, in a multisite, randomized controlled trial, a decision support intervention (i.e., Periviable GOALS DST) developed by our research team to facilitate informed, shared decision-making regarding neonatal resuscitation among women who present to labor and delivery at periviable gestations (from 22 0/7 to 24 6/7 weeks gestational age) and their physicians. The proposed work stands to improve the quality of periviable care by enabling more informed and patient-centered decisions, and our results will have immediate clinical relevance because the regional and institutional diversity of our trial sites, which improves generalizability, allowing for broad application and dissemination of the tool.

PI_NAMEs: KUPPERMANN, MIRIAM ;TUCKER EDMONDS, BROWNSYNE M (contact)

PROGRAM_OFFICER_NAME: COA, KISHA

PROJECT_TITLE: Promoting Shared Decision Making in Periviable Care: A randomized controlled trial of the Periviable GOALS Decision Support Tool

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PROJECT_TERMS: aging brain;Algorithms;Alzheimer's Disease;Alzheimer's disease therapeutic;Amyloid;Artificial Intelligence;Bioinformatics;Biological Markers;biomarker discovery;Biometry;Biostatistics Core;Clinical;Clinical Research;Clinical Trials Design;Cognitive;Collaborations;Communities;Complex;Consultations;Consumption;Data;Data Analyses;Data Discovery;data integration;data quality;data reduction;Data Reporting;Data Set;design;Disease;Disease Marker;disorder prevention;Doctor of Philosophy;Ensure;Epidemiologist;Equation;experience;Faculty;Generations;Genetic;Genomics;Health;health disparity;Health Promotion;Image;improved;Individual;Informatics;Infrastructure;innovation;International;Lead;life span;Machine Learning;machine learning method;machine learning model;Mediation;metabolomics;method development;Methodology;Methods;Modeling;Modernization;Monitor;Nerve Degeneration;neuroimaging;Neurology;novel;novel marker;Outcome;Pathologic;Population Heterogeneity;power analysis;Preventive Medicine;prognostic;programs;Proteomics;Protocols documentation;Publications;Qualifying;Quality Control;recruit;Research;Research Design;Research Institute;Research Methodology;Research Personnel;Resources;Safety;Specific qualifier value;Statistical Data Interpretation;Statistical Methods;tau Proteins;Training;Update;Work

PROJECT_TITLE: HABS-HD - Core F - Biostatistics Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE These studies seek to understand if targeting integrins on myeloid cells can impact therapeutic responsiveness to immunotherapy in pancreas cancer. They include studies clinically testing an integrin agonist in PDAC patients and correlative and laboratory studies to understand mechanism of resistance.

PI_NAMEs: DENARDO, DAVID G (contact)

PROJECT_TERMS: Abraxane;Agonist;Biological;Biological Markers;Blood;cancer type;Cell Lineage;Cellular Immunity;checkpoint therapy;chemokine receptor;Clinical;Clinical Research;Clinical Trials;Colorectal Cancer;combat;Combination immunotherapy;Combined Modality Therapy;Correlative Study;Data;Dimensions;Disease Progression;Drug Combinations;Elements;Event;Exclusion;Functional disorder;gemcitabine;Genetically Engineered Mouse;granulocyte;Human;IL8RA gene;Immunity;Immuno-Chemotherapy;Immunologic Memory;Immunologics;Immunotherapy;Impairment;improved;Infiltration;Integrins;Interferons;ITGAM gene;Laboratory Study;Lead;Macrophage;Macrophage Colony-Stimulating Factor Receptor;Malignant neoplasm of esophagus;Malignant neoplasm of pancreas;Malignant Neoplasms;Molecular;monocyte;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasm Metastasis;novel strategies;novel therapeutics;p65;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;participant enrollment;Patients;PD-1 blockade;pembrolizumab;Phase;Phase I Clinical Trials;pre-clinical;Pre-Clinical Model;programmed cell death protein 1;programs;Publishing;recruit;Research Personnel;Resistance;resistance mechanism;response;Safety;safety testing;Signal Pathway;Signal Transduction;Site;Slice;success;System;T-Lymphocyte;targeted agent;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Time;Tissues;Translating;Treatment Efficacy;tumor;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;Universities;unpublished works;validation studies;Washington

PROJECT_TITLE: Project 1: Employing CD11b-Agonists to Render PDAC Responsive to Immunotherapy


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Clinical Research;Genetics;Mental Health;Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE Over 10 million people worldwide live with Parkinson’s Disease (PD) - the world’s second most prevalent neurodegenerative disease: PD’s economic cost is ~$14.4 billion in the U.S. alone. Here we launch ENIGMA’s Worldwide Parkinson’s Initiative - the largest and most highly-powered neuroimaging investigation of PD - pooling data from 21 cohorts from North America (US), South America (Brazil), Europe (Netherlands, Belgium, Italy, Austria, Switzerland, UK), Asia (China, Taiwan, Japan), Africa (South Africa) and Oceania (New Zealand). Using global data to offer unprecedented power, we will identify genomic, interventional, and environmental factors that consistently impact disease severity and progression, supporting the development of personalized treatments.

PI_NAMEs: POSTON, KATHLEEN LOMBARD;THOMPSON, PAUL M (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Affect;Africa;Age of Onset;Amygdaloid structure;Anatomy;Anterior;Area;Asia;Atrophic;Attenuated;Austria;autism spectrum disorder;Basal Ganglia;Belgium;biobank;Biological Markers;biological sex;biotypes;Bipolar Disorder;Bradykinesia;Brain;Brain Diseases;Brain imaging;Brazil;burden of illness;China;cholinergic;Clinical;Clinical Trials;Cognitive;Cognitive deficits;cognitive impairment in Parkinson's;cohort;Collaborations;Corpus Callosum;Corpus striatum structure;Corticospinal Tracts;Country;Data;Data Pooling;Data Set;Data Sources;design;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Dimensions;Disease;disease diagnosis;Disease Progression;disorder risk;disorder subtype;diverse data;economic cost;empowerment;Environmental Risk Factor;Epilepsy;Europe;Foundations;functional decline;Functional Magnetic Resonance Imaging;Future;Gait;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genomics;Head;Image;imaging biomarker;imaging genetics;imaging study;Impaired cognition;improved;Impulsivity;indexing;Individual;International;Intervention;Investigation;Italy;Japan;Learning;Least-Squares Analysis;Letters;magnetic resonance imaging biomarker;Major Depressive Disorder;Measures;Mental Depression;Modeling;Motor;Motor Cortex;Movement;Movement Disorder Society Unified Parkinson's Disease Rating Scale;multimodal data;Multimodal Imaging;multimodal learning;multimodality;Nerve Degeneration;Netherlands;neural;Neurodegenerative Disorders;neuroimaging;neuropsychiatry;New Zealand;North America;Oceania;Parkinson Disease;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;personalized medicine;Persons;Pharmaceutical Preparations;Phenotype;polygenic risk score;Posture;predict clinical outcome;Predictive Factor;predictive modeling;Protocols documentation;Publishing;putamen;rate of change;Reproducibility;Research;response;Rest;Risk;Risk Factors;risk variant;Russia;Sample Size;Scanning;Schizophrenia;Severities;Severity of illness;shape analysis;simulation;Source;South Africa;South America;Structure;Structure of inferior temporal gyrus;Susceptibility Gene;Switzerland;Symptoms;Taiwan;Testing;Thalamic structure;thalamocortical tract;Thick;translational goal;Treatment Efficacy;treatment response;Tremor;United States National Institutes of Health;uptake;white matter

PROJECT_TITLE: ENIGMA Parkinson’s Initiative: A Global Initiative for Parkinson’s Disease

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Address;Adult;African American;African American population;aging brain;Ally;Alzheimer's Disease;Alzheimer's disease related dementia;Behavioral;Biological Markers;Biometry;career;Career Mobility;Clinical;Clinical Research;cohort;Communities;community engaged research;Competence;cultural competence;Data;design;Development;Diagnosis;Diverse Workforce;diversity and inclusion;economic cost;Education;Effectiveness;effectiveness measure;Ensure;Epidemiology;Ethnic Population;Faculty;Financial Support;Fostering;Foundations;Funding;Goals;Grant;Health;Health Disparities Research;health disparity;Hispanic Populations;innovation;Interdisciplinary Study;interest;knowledgebase;Leadership;leadership development;Life Cycle Stages;Light;Linguistics;Mentors;Mentorship;Morbidity - disease rate;multi-ethnic;neuroimaging;neuropathology;Neuropsychology;Neurosciences;Not Hispanic or Latino;novel;older adult;Persons;Population;Postdoctoral Fellow;professional students;programs;Publications;recruit;Reporting;Research;Research Personnel;Resources;satisfaction;Science;science education;skills;Slice;socioeconomics;success;tenure track;Time;Training;Training Programs;translational engagement;Underrepresented Populations;United States National Institutes of Health

PROJECT_TITLE: HABS-HD - Core G - Development Core


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health;Substance Misuse

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: The ILLUMINATE study promises to produce a greater understanding of coping behavior as a key mechanism of action in the linkages between social isolation, loneliness, and alcohol use/misuse. Possessing greater understanding of this interplay will open important new avenues for developing and implementing more effective, contextually valid prevention and intervention efforts for substance use and misuse with the potential for substantial public health impacts.

PI_NAMEs: FENDRICH, MICHAEL ;PARK, CRYSTAL L. (contact);RUSSELL, BETH S

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Address;Adult;Alcohol abuse;Alcohol consumption;alcohol misuse;Anniversary;Articulation;Automobile Driving;Behavioral Mechanisms;behavioral response;Calibration;Chronic;Chronic stress;commune;Complex;coping;Coping Behavior;COVID-19;COVID-19 pandemic;Crime;Data;Data Reporting;design;Economics;emotion regulation;Environment;ethnic segregation;Feeling;Funding Opportunities;Future;future pandemic;Geographic Locations;Geography;Hand;high risk;high risk drinking;housing instability;indexing;Individual;Infection;Intervention;Link;Location;Loneliness;Measures;Mediating;Modeling;National Institute on Alcohol Abuse and Alcoholism;new pandemic;pandemic disease;pandemic impact;Participant;Patient Self-Report;Persons;Play;post-pandemic;Prevention;Process;prospective;Prospective Studies;Public Health;Racial Segregation;Recovery;Research;Role;Sampling;Services;Social Interaction;Social isolation;social stressor;social vulnerability;Societies;Specific qualifier value;Stress;Stress and Coping;stress management;stressor;substance misuse;substance use;Surveys;Testing;Time;Transact;trend;Unemployment;United States;United States National Institutes of Health;Waxes

PROJECT_TITLE: Isolation and Loneliness Underlying Misuse and Increased Use of Alcohol as a function of Stress and Coping Efforts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-P(90)S]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Aducanumab;Adult;African American;African American population;age effect;Age of Onset;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Apolipoproteins;Biological;Biological Markers;Blood;blood-based biomarker;Classification;Clinic;Clinical Trials;Cognitive;Collaborations;Communities;Data;dementia risk;Diagnostic;diagnostic platform;Diagnostic Procedure;Diffusion Magnetic Resonance Imaging;Disease Outcome;emerging adult;Ethnic Origin;Ethnic Population;experience;Gene Frequency;Genetic Markers;genomic biomarker;Genotype;Health;health data;health disparity;health goals;Hispanic;Hispanic Populations;Hypertension;Individual;late life;Link;Literature;Magnetic Resonance Imaging;Mexican Americans;mild cognitive impairment;Nerve Degeneration;Not Hispanic or Latino;novel;Participant;Pattern;PET positivity;Pharmaceutical Preparations;Plasma;Population;Population Heterogeneity;Positron-Emission Tomography;precision medicine;Prevention strategy;Race;racial population;Research;screening;Screening procedure;sociocultural determinant;tau Proteins;Testing;Therapeutic;treatment strategy;Work

PROJECT_TITLE: HABS-HD - Project 1


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunization;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases;Vaccine Related

PHR: PROJECT NARRATIVE Cancer neoantigens are important targets of cancer immunotherapy. Neoantigen vaccines have generated great enthusiasm as a potential safe and effective strategy to induce/enhance the immune response to pancreatic cancer. We have obtained funding to test optimized neoantigen vaccines in a window trial in pancreatic cancer, and propose preclinical and human translational studies to assess the mechanisms of response and resistance to neoantigen vaccines in pancreatic cancer.

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Agonist;Algorithms;anti-PD1 antibodies;anti-tumor immune response;antigen-specific T cells;Biology;Biomedical Research;cancer immunobiology;cancer immunotherapy;CD8B1 gene;Clinical Trials;Clinical Trials Design;Correlative Study;Coupled;Data;Development;Dimensions;DNA Vaccines;early phase clinical trial;Enrollment;exhaustion;FLT3 ligand;Functional disorder;functional improvement;functional status;Funding;Generations;Human;Immune response;Impairment;improved;in vivo;innovation;Licensing;Malignant neoplasm of pancreas;Malignant Neoplasms;manufacture;Neoadjuvant Therapy;neoantigen vaccine;neoantigens;Operative Surgical Procedures;pancreatic ductal adenocarcinoma model;Pathway interactions;patient population;Patients;Peptide Vaccines;peripheral blood;Phase I Clinical Trials;pre-clinical;Pre-Clinical Model;predict clinical outcome;Publishing;Resistance;resistance mechanism;response;restraint;Role;safety assessment;Signal Transduction;single-cell RNA sequencing;Software Tools;Specimen;success;Synthetic Antigens;T cell receptor repertoire sequencing;T cell response;T-Lymphocyte;Testing;Therapeutic;TNFRSF5 gene;translational study;trial design;tumor;Tumor Immunity;tumor microenvironment;Tumor Tissue;Universities;Vaccination;Vaccine Design;vaccine platform;Vaccine Therapy;Vaccines;Washington

PROJECT_TITLE: Project 2: Mechanisms of Resistance to Neoantigen Vaccines in PDAC


PROJECT_TERMS: Adult;African American population;Age;age effect;Age of Onset;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Anti-Inflammatory Agents;apolipoprotein E-4;Biological Markers;Blood Vessels;burden of illness;Clinical;Clinical Trials;Cognition;Collaborations;comorbidity;Data;dementia risk;diabetic;Disease Outcome;ethnic difference;Ethnic Origin;Ethnic Population;Etiology;experience;Genetic Markers;Genotype;Health;health disparity;Hispanic Populations;Impaired cognition;Inflammation;Inflammatory;late life;Link;Medical;Metabolic;Mexican Americans;middle age;mild cognitive impairment;National Institute on Aging;Nerve Degeneration;neuroimaging;Not Hispanic or Latino;Outcome;Participant;Pathway interactions;patient subsets;Pattern;Pharmaceutical Preparations;Population;Population Heterogeneity;Prediction of Response to Therapy;Prevalence;Proteomics;Race;racial difference;racial population;Research;Risk;tau Proteins;Testing;TREM2 gene;vascular factor;Work

PROJECT_TITLE: HABS-HD - Project 2


PROJECT_TERMS: Acculturation;African American population;age effect;Age of Onset;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Area;Autopsy;Biological;Biological Markers;Blood Vessels;burden of illness;Childhood;Cognition;Cognitive;cognitive function;Collaborations;Data;deprivation;Disease;Disease Outcome;Disparate;Disparity;epigenetic marker;Epigenetic Process;ethnic difference;Ethnic Population;executive function;experience;Health;Health Disparities Research;health disparity;Hispanic Populations;Household;Impaired cognition;Income;indexing;Inflammation;Inflammatory;Intervention;Language;Lead;Link;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Memory;Metabolic;Metabolic dysfunction;methylation pattern;Mexican Americans;middle age;neighborhood disadvantage;Neighborhoods;Nerve Degeneration;neuropathology;Not Hispanic or Latino;Outcome;Pathologic;Plasma;Population Heterogeneity;Prevalence;Race;racial difference;racial population;racism;Research;Research Personnel;residential segregation;Risk;social culture;social factors;sociocultural determinant;Stress;successful intervention;tau Proteins;theories;trend

PROJECT_TITLE: HABS-HD - Project 3


NIH_SPENDING_CATS: Biotechnology;Cachexia;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE Extreme resistance to chemotherapy is one of the major factors that underlies the poor prognosis of pancreatic cancer. Using an unbiased protein array analysis, we have identified a novel mechanism of resistance governed by MK2 kinase, that when overcome, renders chemotherapy effective. In this study we propose to conduct a phase 1 clinical trial combining a novel MK2 inhibitor ATI-450 with FOLFIRINOX chemotherapy for patients with metastatic pancreatic cancer and to develop a novel immunotherapeutic strategy that can be tested in the future.

PI_NAMEs: LIM, KIAN H (contact)

PROJECT_TERMS: Ablation;Aftercare;Animal Model;anti-cancer;autocrine;Autoimmune Diseases;Autophagocytosis;biological adaptation to stress;Blood specimen;Cachexia;cancer cell;Cell Death;Cells;Cessation of life;chemotherapy;Chemotherapy-Oncologic Procedure;Clinic;Clinical;Clinical Research;clinical trial protocol;Clinical Trials;Combination Drug Therapy;combinatorial;conditional knockout;cytokine;Development;Diagnosis;Disease;Dizziness;DNA;Dose;effector T cell;Ensure;Enzymes;Exhibits;experience;Exposure to;Fibrosis;Fluorouracil;Future;gastrointestinal;Genetic;Headache;HSPB1 gene;Human;Immune;Immunohistochemistry;Immunologics;Immunologist;Immunotherapeutic agent;Immunotherapy;improved;Inflammatory Response Pathway;Infrastructure;inhibitor;Institution;investigator-initiated trial;irinotecan;Knockout Mice;KPC model;Lead;Leucovorin;Malignant neoplasm of pancreas;Malignant Neoplasms;MAPKAPK2 gene;Mediating;Mediator;Mitogen-Activated Protein Kinases;mouse model;Mus;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncology;Operative Surgical Procedures;Oral;oxaliplatin;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Patients;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Phenotype;Phosphotransferases;Physicians;pre-clinical;preclinical efficacy;Predisposition;prevent;Prognosis;Protein Array Analysis;Protein Kinase;Publishing;Recommendation;Records;Regimen;Reporting;Research;Resistance;Resistance development;resistance mechanism;response;Rheumatoid Arthritis;Safety;safety assessment;safety testing;Sampling;Scientist;Signal Transduction;single-cell RNA sequencing;Stress;targeted treatment;Techniques;Testing;therapy outcome;TNF gene;Toxic effect;translational medicine;Translational Research;Treatment Efficacy;treatment response;Treatment-related toxicity;tumor;Tumor Immunity;Tumor-associated macrophages;Tumor-infiltrating immune cells;tumorigenic;Universities;Washington;Work

PROJECT_TITLE: Project 3: Targeting Stress-induced MK2 as Novel Strategy in Pancreatic Cancer


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Diabetes poses a major health threat in the US, and there is a disproportionate burden of diabetes among African Americans. However, the environmental and/or genetic reasons remain incompletely defined. Our goal is to use novel technologies to study blood chemistry to identify those most at risk so that preventive interventions can be made as early as possible – and to improve our understanding of the underlying disease mechanisms.

PI_NAMEs: CLISH, CLARY B;GERSZTEN, ROBERT E (contact);WANG, THOMAS J.;WILSON, JAMES GRAHAM

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acetylation;Acids;Adenosine Monophosphate;African American population;Amino Acids;Aromatic Amino Acids;Award;Base Sequence;Biochemical Markers;bioinformatics tool;Biological Markers;Biological Models;Biology;Blood Chemical Analysis;Caucasians;causal variant;Cells;Classification;Clinical;clinical risk;Clinical Trials;cohort;Collaborations;Communities;Complement;Cytosine;Data;Diabetes Mellitus;diabetes prevention program;Diagnosis;diet and cancer;Disease;disorder risk;Enzymes;Ethnic Population;Etiology;experimental study;fasting glucose;Fatty acid glycerol esters;Framingham Heart Study;Funding;Future;gain of function;Genes;Genetic;genetic architecture;genetic variant;genome wide association study;genome-wide;glucose tolerance;Glutamates;Glutamine;Glycosylated hemoglobin A;Goals;Health;Heterogeneity;High Prevalence;high risk;Human;Hyperglycemia;Imidazole;improved;Incidence;Individual;Institution;Insulin;Insulin Resistance;Jackson Heart Study;Laboratories;Life Style;Lipids;Liver;loss of function;Maps;Mass Spectrum Analysis;Mendelian randomization;Meta-Analysis;Metabolic;Metabolic Diseases;metabolome;metabolomics;Metformin;multi-ethnic;Muscle;n-pentanoic acid;Names;new technology;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;offspring;Outcome;Pancreas;Participant;Pathway interactions;Phospholipids;population based;Predictive Value of Tests;preventive intervention;Propionates;Proteins;Randomized;Recording of previous events;Resources;Risk;Risk Factors;risk variant;solute;sphinganine;Stratification;Taurine;Techniques;Testing;Time;Tissues;trait;Triglycerides;uptake;Variant;whole genome;Work;young adult

PROJECT_TITLE: Metabolomic predictors of insulin resistance and diabetes

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE Signaling between tumor cells and their host environment that results in enhanced tumor cell survival via diverse mechanisms, growth and promotion of invasion into other tissues. Most cancer victims succumb to their disease because of the size of the tumor and/or metastases to different organs. This CoBRE will 1) increase our mechanistic understanding of the interaction between the tumor and its environment, 2) position junior faculty for success by improving competitiveness for extramural support through diverse training opportunities and specific mentoring strategies and 3) support critical infrastructure for the projects of focus in the current application but also to recruit additional tumor microenvironment focused scientists to West Virginia.

PI_NAMEs: LOCKMAN, PAUL R (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Annual Reports;Apoptosis;Appalachian Region;Area;Atmosphere;Award;Biology;Biometry;Bone Marrow;Bone Marrow Neoplasms;Brain;Breast;Breast Cancer Detection;Budgets;cancer cell;cancer initiation;career;career life balance;Cell Survival;Centers of Research Excellence;Cessation of life;Clinical Informatics;Clinical Research;clinical translation;Collaborations;Communication;Core Facility;course development;Cues;Data;defined contribution;Development;directional cell;Disease;Education;Education and Outreach;Environment;Enzymes;Extramural Activities;Faculty;Faculty Recruitment;Feedback;Flow Cytometry;Foundations;Funding;gastric carcinogenesis;Gastritis;Goals;Grant;Growth;health disparity;Health Sciences;Helicobacter Infections;Image;imaging agent;Immune system;Immunotherapy;improved;Individual;Infrastructure;Institution;Invaded;Investigation;Investments;irradiation;Joints;Laboratories;Leucine Zippers;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;meetings;Melanoma;member;Mentors;microCT;mortality;Multi-Drug Resistance;Multiple Myeloma;Myeloid-derived suppressor cells;National Institute of General Medical Sciences;Neoplasm Metastasis;neoplastic cell;neutrophil;novel therapeutic intervention;Organ;outreach program;pancreatic neoplasm;Paper;peer;Personal Satisfaction;Phase;Physical environment;Physiological;Pilot Projects;Positioning Attribute;pre-clinical;Productivity;programs;Proliferating;Publications;Publishing;Reactive Oxygen Species;recruit;Research;Research Infrastructure;Research Personnel;Research Support;Resources;response;Role;Schools;Scientist;Signal Transduction;single cell analysis;single cell genomics;Stomach;Students;success;System;Teacher Professional Development;Techniques;Technology;Time;Tissues;Training;training opportunity;transcription factor;Translational Research;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Suppression;tumor-immune system interactions;undergraduate student;Universities;West Virginia;Workforce Development

PROJECT_TITLE: Tumor Microenvironment-TME CoBRE


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Despite the increased risk of cervical cancer for women living with HIV, access to cervical cancer screening in Nigeria is limited. We will leverage existing HIV treatment infrastructure in Nigeria to integrate cervical cancer control activities into the successful MoMent (MOther MENTor) peer-based HIV support program. Using implementation science frameworks, we will implement and evaluate the sustainability of the adapted MoMent HIV + Homebased Cervical Cancer program to advance cervical cancer control in Nigerian women living with HIV.

PI_NAMEs: AWOLUDE, OLUTOSIN ;EZECHI, OLIVER CHUKWUJEKWU;FLOWERS, LISA C. (contact);GAYDOS, LAURA M;OGUNSOLA, OLABANJO OKUNLOLA

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: Adherence;Administrator;Adoption;Advanced Malignant Neoplasm;Aftercare;Age;AIDS related cancer;Anti-Retroviral Agents;Attitude;Belief;Cancer Control;Cancer Intervention;cancer risk;Caring;Cervical;Cervical Cancer Screening;Characteristics;Clinic;Clinical;Communities;Consensus;Consolidated Framework for Implementation Research;Data;Decision Making;Diagnostic Reagent Kits;Disadvantaged;Education;Effectiveness;Eligibility Determination;Ensure;Evaluation;evidence base;experience;Female;Focus Groups;follow-up;health service use;Health Status;High Prevalence;Highly Active Antiretroviral Therapy;HIV;HIV Seronegativity;HIV Seropositivity;HIV/AIDS;Home;home test;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Impact evaluation;implementation evaluation;implementation fidelity;implementation framework;implementation process;Incidence;Individual;Infrastructure;innovation;insight;Intervention;Interview;Lesion;low and middle-income countries;Maintenance;male;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;Mentors;Methodology;Methods;Modeling;Monitor;mortality;Mothers;Nigeria;Nigerian;outreach;Participant;peer;peer support;Persons;Pharmaceutical Preparations;Phase;Policy Maker;post implementation;premalignant;Prevention;Prevention program;primary health center;Process;process evaluation;Professional counselor;program costs;programs;Published Comment;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Records;Recurrence;Resources;Risk;routine practice;Rural Community;Sampling;scale up;screening;Screening for cancer;screening program;screening services;Shapes;social stigma;Structure;Support Groups;symposium;System;systematic review;Training;treatment program;Vertical Disease Transmission;Viral;Viral Load result;Woman;women's treatment

PROJECT_TITLE: The CHESS (Community, Home-based Education, Screening Services) Strategy to increase cervical cancer control access for HIV positive women in Nigeria


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer

PROJECT_TERMS: Accounting;Advisory Committees;Area;Award;Benchmarking;Budgets;Businesses;career;Centers of Research Excellence;Clinical Sciences;cohort;commercialization;Communication;Data;Department chair;Development;Educational Curriculum;Educational workshop;Entrepreneurship;Environment;Evaluation;Expenditure;experience;Experimental Designs;Faculty;formative assessment;Future;Grant;Growth;Health Sciences;Human Resources;improved;innovation;Institution;International;Investments;Leadership;Malignant Neoplasms;Measurable;Measures;meetings;member;Mentors;Monitor;National Institute of General Medical Sciences;Nature;next generation;Outcome;peer;Pharmacy Schools;Phase;Pilot Projects;Play;Process;programs;Recommendation;recruit;Reporting;Reproducibility;Research;Research Personnel;Resources;Role;Science;Scientist;senior faculty;Services;skill acquisition;Stroke;Structure;success;synergism;Technology;Time;Training;Translational Research;tumor microenvironment;tumor progression;United States National Institutes of Health;Universities;Update;Vision;vision science;West Virginia;Writing

PROJECT_TITLE: TME Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE The biospecimen core will support the proposed SPORE projects that will lead to both an improved understanding of the pathogenesis and new approaches for the detection, prevention, and treatment of pancreatic ductal adenocarcinoma.

PI_NAMEs: FIELDS, RYAN C (contact)

PROJECT_TERMS: Adenocarcinoma Cell;Aftercare;anti-cancer research;Attention;biobank;bioinformatics infrastructure;Biological Models;Biological Specimen Banks;Biology;biomedical informatics;Biopsy;Blood;Cancer Biology;cancer cell;Cancer Center;cell free DNA;chemotherapy;Clinical;Clinical Data;clinical database;cohort;Collaborations;Collection;Communities;Consent;Cryopreservation;Data;Databases;Dedications;Detection;Diagnosis;Disease;DNA amplification;Enrollment;Ensure;Epidemiology;Evolution;follow-up;Freezing;Funding;Future;Genomic DNA;Genomics;Goals;Grant;Harvest;Immune system;Immunologics;improved;in vivo Model;individual patient;Informatics;Institution;Institutional Review Boards;Investigation;Lesion;Liquid substance;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;medical schools;Metadata;Molecular;neoplasm resource;neoplastic cell;Newly Diagnosed;Normal tissue morphology;novel strategies;Operative Surgical Procedures;Organoids;Outcome;Pancreas;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;Pathogenesis;Pathologic;Pathologist;Pathology;patient derived xenograft model;Patient-Focused Outcomes;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Plasma;Population;premalignant;preservation;Prevention;Process;programs;prospective;Proteins;Protocols documentation;Quality Control;Radiation;Research;Research Personnel;research study;Resected;Resource Informatics;Resources;RNA;sample collection;Sampling;Science;Serum;Solid;Solid Neoplasm;Source;Specimen;success;Testing;therapy resistant;Time;Tissue Banks;tissue culture;Tissue Expansion;tissue processing;Tissue Procurements;tissue registry;Tissues;Transcript;Translational Research;treatment response;tumor;Tumor Bank;Tumor Biology;Tumor Cell Line;tumor microenvironment;Tumor Tissue;Universities;Urine;Washington;whole genome;Xenograft procedure

PROJECT_TITLE: Core B: Biospecimen Core


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: BROOKLYN

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: Project Narrative Despite widespread recognition of the benefit of having more than one mentor for success in biomedical research, the roles and types of mentors important for early career researchers is not well-understood. This application will identify and test patterns of successful mentorship networks to enhance biomedical research outcomes and close mentoring gaps for trainees from underrepresented backgrounds.

PI_NAMEs: LAMBERT, WILLIAM MARCUS (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Academia;Academic support;Affect;Biomedical Research;career;career development;Characteristics;Disparity;Faculty;feasibility testing;Funding;Goals;Grant;Individual;Intervention;Investments;Maps;Measures;meetings;Mentors;Mentorship;Modeling;Outcome;Outcomes Research;Pathway Analysis;Pattern;Persons;Postdoctoral Fellow;primary outcome;Program Development;psychosocial;Psychosocial Assessment and Care;Publications;Research;Research Personnel;Research Training;Role;Science;secondary outcome;Self Efficacy;success;Testing;Time;tool;Training;trend;Underrepresented Populations

PROJECT_TITLE: Understanding the Science of Effective Mentorship Networks for Underrepresented Researchers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-L(55)R]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative There is a critical lack of individuals from under-represented segments of the US population in the toxicology workforce and the Society of Toxicology (SOT) is pleased to serve as a partner in the Toxicology Mentoring and Skills Development Training (ToxMSDT) Program that has a purpose to mentor high undergraduate students from underrepresented groups to build a pathway for toxicology research and workforce. Together SOT and the ToxMSDT will establish a sustained network of toxicology students, researchers, and professionals committed to expanding toxicology mentoring and career opportunities for underrepresented segments of the US population. Thus, contributing to the development of a diverse toxicology workforce in solving toxicology-related health issues.

PI_NAMEs: FLAWS, JODI A.;RUMBEIHA, WILSON KIIZA (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;Admission activity;Adverse effects;African American population;Alaska Native;Animals;Area;Awareness;Behavioral Research;Biomedical Research;California;career;Case Study;Chemicals;Clinical Research;Collaborations;Complement;Computers;Country;Critical Thinking;design;Development;disadvantaged background;Discipline;Disparity population;Diverse Workforce;Educational Activities;Educational process of instructing;Engineering;Enrollment;Environment;Environmental Exposure;Environmental Health;Environmental Science;Ethics;Exercise;experience;flexibility;Funding Mechanisms;Funding Opportunities;Future;General Population;Goals;Government;Graduate Education;graduate school;handheld mobile device;Health;Health Sciences;Hispanic Americans;Human;Individual;Industry;innovation;Institution;interest;Internet;Internships;Iowa;job market;Knowledge;Latino Population;Link;Mentors;National Institute of Environmental Health Sciences;Native Hawaiian or Other Pacific Islander;novel strategies;Ohio;online course;online delivery;Organism;Outcome;outreach program;Pathway interactions;Policies;Population;Problem Solving;programs;Qualifying;recruit;Reproducibility;Research;Research Personnel;responsible research conduct;Role;scale up;Science;Science, Technology, Engineering and Mathematics;Scientist;skill acquisition;skills;skills training;Societies;Solid;Source;STEM student;Structure;Student recruitment;student training;Students;success;Toxicology;Training;Training Activity;Training Programs;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;Woman;Workplace

PROJECT_TITLE: ToxMSDT: An Innovative Toxicology Pathway mentoring program targeting underrepresented STEM students


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer

PI_NAMEs: MARTIN, KAREN H (contact)

PROJECT_TERMS: 3-Dimensional;Address;Animal Disease Models;Animal Model;Animals;Award;Biomedical Research;Cancer Biology;cancer care;Cancer Patient;Cell model;Cells;Centers of Research Excellence;Clinical Research;Collaborations;Communities;Complex;Contract Services;Core Facility;Data Analyses;Dedications;design;Detection;Development;Disease Progression;Education;Ensure;Equipment;experience;Experimental Designs;extracellular;Extramural Activities;Flow Cytometry;fluorescence imaging;Funding;Goals;health disparity;Health Sciences;human model;Image;imaging facilities;improved;In Vitro;in vivo imaging;Individual;Institution;instrumentation;intravital imaging;Investments;Journals;Light;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;member;Mentors;Microscope;Microscopy;Modeling;Monitor;mouse model;multi-photon;new technology;new therapeutic target;novel;operation;Organ;Perfusion;Phase;Postdoctoral Fellow;pre-clinical;Pre-Clinical Model;Program Sustainability;programs;Publications;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resolution;Resources;Rodent Model;Series;Services;Signal Pathway;single cell analysis;structural imaging;Students;success;synergism;Technology;therapeutic target;tool;Training;training opportunity;Training Programs;Translational Research;treatment response;tumor;Tumor Biology;tumor growth;tumor microenvironment;Tumor Volume;ultra high resolution;ultrasound;Universities;Wages;West Virginia;whole animal imaging

PROJECT_TITLE: Imaging Core


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Digestive Diseases;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE The development and application of new computational methodology for cancer research has expanded roles for statisticians and computational experts. The Biostatistics and Bioinformatics Core provides the statistical, bioinformatics, and computational support for all SPORE in Pancreatic Cancer investigators. Core C will support consultation and collaboration on all aspects of study design, database development and quality control, and data analysis, interpretation, and presentation of data.

PI_NAMEs: COLDITZ, GRAHAM A. (contact)

PROJECT_TERMS: Adverse event;anti-cancer research;Bioinformatics;bioinformatics pipeline;bioinformatics tool;Biometry;Cancer Center;career;Clinical Cancer Center;Clinical Trials;Collaborations;Computing Methodologies;Consult;Consultations;Data;Data Analyses;Data Collection;data integration;data management;Data Set;data sharing;Databases;design;Development;Ensure;epidemiology study;experience;genomic data;Genomics;High Performance Computing;laboratory experiment;Malignant neoplasm of pancreas;medical schools;meetings;member;multidimensional data;Output;Pancreas;programs;Quality Control;Reporting;Reproducibility;Research;Research Design;Research Personnel;Resource Sharing;Role;Statistical Methods;Statistical Study;System;Tissue Sample;Training;Universities;Visualization;Washington;Work

PROJECT_TITLE: Core C: Biostatistical and Bioinformatics Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Estrogen;Genetics;Human Genome;Neurosciences;Precision Medicine;Prevention;Stroke;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Stroke is a leading cause of death and disability globally and in the United States for both women and men, and sex differences in both risk factors and stroke incidence have been consistently demonstrated. We lack, however, a detailed understanding of pathways by which alterations in sex hormones contribute to stroke risk in women and men, knowledge that could help to inform improved, more personalized stroke prediction and prevention. Our planned project will use the biologic footprints (genomic, epigenomic, and metabolomic data) of individuals in national and international prospective cohort studies to advance our knowledge of the critical role of sex hormones in stroke risk in women and men across the lifespan, enabling more personalized approaches to stroke prevention and improved brain health in the population.

PI_NAMEs: MADSEN, TRACY  (contact)

PROGRAM_OFFICER_NAME: JAQUISH, CASHELL E

PROJECT_TERMS: Adult;Age;age related;Ancillary Study;Biological;biological age;biological sex;brain health;Cardiovascular Diseases;Cardiovascular system;Cause of Death;cerebrovascular;Cessation of life;Clinical;cohort;Cohort Studies;Conflict (Psychology);Data;Diabetes Mellitus;disability;Disease Outcome;DNA Methylation;Epidemiologist;Epidemiology;epigenomics;Etiology;Female;Gender;Genetic;Genetic Determinism;Genetic Risk;Genomic approach;Genomics;Genotype;Gonadal Steroid Hormones;Health;Hormones;improved;Incidence;Individual;International;Knowledge;Life Cycle Stages;life span;Life Style;Link;Longitudinal Studies;male;Measurable;Measures;Mediating;Mediation;men;Mendelian randomization;Metabolic;Metabolic Diseases;metabolomics;Methylation;middle age;Modeling;National Heart, Lung, and Blood Institute;new therapeutic target;novel;Participant;Pathway interactions;Pattern;personalized approach;Phenotype;Physiological;Population;Population Heterogeneity;Postmenopause;predictive modeling;Prevention;Prospective, cohort study;Protocols documentation;Receptor Gene;reproductive;Research Personnel;Residual state;response;Risk;Risk Factors;risk prediction;Role;Science;Series;sex;Sex Differences;Sex Hormone-Binding Globulin;sexual dimorphism;Single Nucleotide Polymorphism;Stroke;stroke event;stroke incidence;Stroke prevention;stroke risk;Trans-Omics for Precision Medicine;United States;Validation;Variant;Woman;Work

PROJECT_TITLE: The Role of Sex Hormones in Stroke Risk: A Sex-Specific Integrative Omics Analysis in the NHLBI Trans-Omics for Precision Medicine Cohorts

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative Membrane proteins represent about 25% of the human genome (~5,000 genes). Of these, about 1700 transmembrane proteins are localized on the plasma membrane (PM) (9% of the genome) and they constitute 60% of the existing FDA-approved drug targets. Understanding the endocytic dynamics of surface receptors are fundamentally important in designing more effective therapies, and the receptors studied in this proposed research will provide new insights in understanding the key drug target for a number of inflammatory and autoimmune diseases in particular.

PI_NAMEs: WU, MIN  (contact)

PROJECT_TERMS: adhesion receptor;Amino Acids;Autoimmune Diseases;Behavior;Binding;Biophysics;CD81 gene;Cell Adhesion;Cell Culture Techniques;Cell membrane;cell motility;Cell Polarity;Cells;cellular imaging;Clathrin;Coupled;Data;design;Disease;Drug Targeting;effective therapy;Endocytosis;Event;experimental study;Extracellular Domain;FDA approved;Fibroblasts;Genes;Genome;genome editing;Homeostasis;Human Genome;Hydrophobicity;Immune;In Vitro;Individual;Inflammatory;insight;Integral Membrane Protein;Integrins;knock-down;Lead;Leukocyte Trafficking;Leukocytes;Link;Lipids;live cell imaging;Macrophage-1 Antigen;Mechanics;Mediating;Membrane;Membrane Potentials;Membrane Protein Traffic;Membrane Proteins;migration;Morphology;novel;Pathway interactions;Pattern;Periodicals;Physiological;PIK3CG gene;Play;Property;protein degradation;Proteins;Proteomics;Reaction;receptor;reconstitution;Regulation;Research;Role;Sorting;Stable Isotope Labeling;Surface;System;Technology;Testing;trafficking;Travel;TRIP10 gene;Tubular formation;Up-Regulation;Work

PROJECT_TITLE: Endocytic dynamics and surface emergent property of leukocyte Integrins

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Human Genome

PI_NAMEs: BRUNDAGE, KATHLEEN M (contact)

PROJECT_TERMS: Address;Area;Award;Bar Codes;Bioinformatics;Biomedical Research;cell separator;Cells;Centers of Research Excellence;Chromium;Collaborations;Complement;Complex;Core Facility;Data Analyses;Development;Environment;Evaluation;experience;experimental study;Extramural Activities;Fees;Flow Cytometry;Funding;Generations;Genomics;Goals;Grant;Guava Fruit;health disparity;Human Resources;Immunology;Institution;instrument;instrumentation;Lasers;Libraries;Life;Magnetism;Maintenance;microvesicles;Mission;new technology;Phase;Phenotype;Pilot Projects;Postdoctoral Fellow;Process;Property;quality assurance;Raven;Research;Research Personnel;Research Project Grants;Research Support;Sampling;Services;single cell analysis;single cell genomics;Solid Neoplasm;Sorting;Structure;Students;System;Technical Expertise;Technology;Training;Training and Education;tumor;tumor growth;tumor microenvironment;United States National Institutes of Health;Work

PROJECT_TITLE: Flow Cytometry & Single Cell Core Facility (FCSCCF)


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE The Developmental Research Program (DRP) will recruit and support innovative early stage research in pancreatic cancer.

PROJECT_TERMS: anti-cancer research;Area;Award;Cancer Biology;cancer prevention;Cancer Research Project;career;Clinical;Clinical Trials;Collaborations;design;Development;disabled;Disabled Persons;Early Diagnosis;Epidemiology;Extramural Activities;Faculty;Fostering;Funding;Future;Goals;Grant;Group Meetings;Image;improved;innovation;Institution;Malignant neoplasm of pancreas;Malignant Neoplasms;meetings;Mentors;Minority;Minority Groups;minority investigator;Minority Recruitment;pancreas development;pancreatic cancer patients;Peer Review;Prevention;Program Research Project Grants;programs;recruit;Refractory;Research;Research Personnel;Research Project Grants;success;Translating;Translational Research;Underrepresented Minority;Universities;Washington;Woman;Work;Writing

PROJECT_TITLE: Developmental Research Program


NIH_SPENDING_CATS: Bioengineering;Cancer;Genetics;Hematology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Next-generation sequence-based techniques can provide an unmatched insight into developmental mechanisms and the defects that lead to or sustain cancer, but the handling and analysis of these large data sets requires methods and approaches not typically part of the skillset of an experimental biologist. The goal of this R50 proposal is to support Dr. Iwanaszko’s efforts in bioinformatics and computational biology, which are focused on understanding oncogenic alterations in chromatin structure and transcription elongation and to evaluate novel cancer therapeutics.

PI_NAMEs: IWANASZKO, MARTA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Acute;Acute Lymphocytic Leukemia;Base Sequence;Bioinformatics;Cancer Biology;Chromatin Structure;Complement Factor B;Complex;Computational Biology;Computer Analysis;Data;Data Analyses;Defect;Development;Dimensions;DNA Polymerase II;Genes;Goals;high standard;insight;large datasets;Machine Learning;Malignant Neoplasms;Methods;MLL gene;Myelogenous;next generation;next generation sequencing;novel;Oncogenic;Reproducibility;Research;Research Design;Research Personnel;RNA;Signal Transduction;skills;Speed;Techniques;Therapeutic;Transcription Elongation;transcription factor;tumorigenesis

PROJECT_TITLE: Computational Approaches for Studying Transcription Elongation Control in Cancer


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases

PI_NAMEs: BOONE, BRIAN A (contact)

PROJECT_TERMS: Ablation;angiogenesis;Arginine deiminase;Automobile Driving;Backcrossings;Binding;Blood Vessels;cancer infiltrating T cells;CD8-Positive T-Lymphocytes;Cells;Characteristics;checkpoint therapy;chemotherapy;Circulation;Combined Modality Therapy;Correlative Study;Cytoplasmic Granules;cytotoxic;Cytotoxic Chemotherapy;Cytotoxic T-Lymphocytes;Data;density;Disease;DNA;Drug Delivery Systems;Dyes;Endothelial Cells;Enzymes;experimental study;extracellular;Extracellular Space;Extravasation;Fibroblasts;Fibrosis;Fostering;Foundations;Functional disorder;Future;Genetic;Genetic Engineering;Granzyme;Histones;Human;Immune;immune cell infiltrate;Immune response;Immunosuppression;Immunotherapy;improved;In Vitro;Inflammatory;inhibitor;innovation;Knowledge;KRAS2 gene;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Modeling;mouse model;Mus;Nature;neutrophil;novel;novel strategies;novel therapeutic intervention;Outcome;Pancreatic Adenocarcinoma;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;pancreatic stellate cell;Pancreatitis;Pathogenesis;PECAM1 gene;Perfusion;pharmacologic;prevent;Protein-arginine deiminase;receptor;receptor for advanced glycation endproducts;Research Personnel;Resistance;resistance mechanism;response;Role;Scientist;Sepsis;Signal Transduction;small molecule;standard of care;stellate cell;Sterility;success;T cell infiltration;T cell response;therapeutic target;therapy resistant;Tissues;TP53 gene;Transgenic Organisms;Translations;treatment effect;treatment response;treatment strategy;tumor;tumor growth;tumor microenvironment;Tumor Promotion;tumor-immune system interactions

PROJECT_TITLE: Role of Neutrophil Extracellular Traps in Pancreatic Cancer


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE While reproductive-age women with rheumatic diseases and their children are at strikingly high risk of adverse pregnancy and perinatal outcomes, little is known about how patient- and health services-level variables (e.g., low patient knowledge, inadequate health services receipt, nonadherence to anti-rheumatic drugs) contribute to these outcomes. As women who make informed pregnancy decisions and have the ability to execute these decisions likely experience better reproductive outcomes, I will develop a novel clinical intervention to enhance pregnancy decision-making and planning in the rheumatology clinical setting. I will also develop a prospective longitudinal cohort of young women with rheumatic diseases to advance understanding about how reproductive knowledge, family planning care receipt, and other key patient and health services variables change over time and predict adherence to anti-rheumatic drugs— which we hypothesize is a critical intermediate factor in the pathway to adverse pregnancy and perinatal outcomes.

PI_NAMEs: TALABI, MEHRET BIRRU (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: acceptability and feasibility;activity marker;Address;Adherence;adverse pregnancy outcome;Affect;Age;Anti-Rheumatic Agents;Behavioral;Belief;Biological;career;career development;Caring;Child;Clinic;Clinic Visits;Clinical;Clinical Trials;clinically relevant;cohort;comparison control;Conceptions;Conduct Clinical Trials;Contraceptive methods;Data;Decision Aid;Decision Making;Development;Diagnosis;Disease;Disease-Modifying Second-Line Drugs;effectiveness/implementation trial;experience;Family Planning;Female;fetal;Fetal Development;Foundations;Fright;Funding;Future;Growth;Gynecologist;Health;health literacy;Health Professional;Health Services;healthy pregnancy;high risk;Hormones;improved;Inflammatory Arthritis;Information Services;Intervention;Knowledge;Lead;Learning;Longitudinal cohort;Maternal Mortality;Medical;medication compliance;medication safety;Mentors;Mentorship;Modeling;novel;Online Systems;Outcome;Outpatients;Pamphlets;Pathway interactions;patient oriented;Patients;perinatal outcomes;Pharmaceutical Preparations;pilot trial;Positioning Attribute;pragmatic implementation;Pregnancy;Pregnancy Outcome;pregnant;Premature Birth;preservation;prevent;Primary Care Physician;prospective;Prospective cohort;reproductive;reproductive outcome;Research Personnel;Rheumatism;rheumatologist;Rheumatology;Risk;Risk Factors;Scientific Inquiry;service gap;Services;Severities;shared decision making;Site;skills;Source;Spontaneous abortion;stillbirth;Surveys;Symptoms;Testing;therapy development;Time;trend;unintended pregnancy;Vulnerable Populations;Woman;Women's cohort;Women's Group;Women's Health;women's morbidity;Women's mortality;women's outcomes;Work;young woman

PROJECT_TITLE: Investigating Pathways to Optimal Reproductive Outcomes Among Women with Rheumatic Diseases

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Pediatric;Pediatric Cancer;Physical Activity;Prevention;Rare Diseases;Rehabilitation;Telehealth

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE With improved treatments, the vast majority of children diagnosed with cancer are now cured. However, premature cardiovascular disease has become the leading non-cancer cause of death among childhood cancer survivors. Using an adaptive study design, the proposed trial seeks to determine if various innovative intervention strategies can help childhood cancer survivors improve their physical activity and dietary habits in order to reduce their long-term risk of early cardiovascular disease.

PI_NAMEs: CHOW, ERIC JESSEN (contact)

PROGRAM_OFFICER_NAME: AGURS-COLLINS, TANYA

PROJECT_TERMS: Accelerometer;active lifestyle;Adolescent;Adult;Age;aged;arm;Attitude;Blood Pressure;Cancer Survivor;cancer therapy;cardiometabolism;Cardiotoxicity;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Caring;Cause of Death;Cessation of life;Child;Childhood;childhood cancer survivor;Childhood Cancer Survivor Study;Chronic Disease;cohort;Competence;Counseling;Decision Making;Development;Diabetes Mellitus;Diagnosis;Diet;Diet Habits;dietary;Dietary Factors;Dyslipidemias;experience;Exposure to;follow-up;Future;General Population;Goals;Health;Healthcare;Healthcare Systems;Healthy Eating;Heart failure;Home;Hypertension;improved;indexing;Inflammation;innovation;Insulin Resistance;Intervention;intervention participants;Intervention Studies;Life Style;lifestyle factors;lifestyle intervention;Lipids;Long-Term Survivors;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Mediator;mHealth;Mobile Health Application;modifiable risk;Morbidity - disease rate;mortality;Myocardial Ischemia;Neighborhoods;Outcome;Participant;patient engagement;peer support;pharmacologic;Physical activity;Physiological;Play;premature;prospective;Randomized;Randomized, Controlled Trials;recruit;remote delivery;Remote session;Research;Research Design;Resources;response;Risk;Risk Factors;Role;secondary analysis;sedentary;Self Determination;Self Efficacy;Self Management;Sequential Multiple Assignment Randomized Trial;sex;social media;Survivors;survivorship;telehealth;Testing;theories;Time;Training;Treatment Efficacy;trial design;Unhealthy Diet;Woman;young adult

PROJECT_TITLE: SALSA - Study of Active Lifestyle Activation