NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE  County governments in the U.S. passed policies during the COVID-19 pandemic that led to job loss, as well as policies that provided economic support. The goal of this research is to catalog the timing and distribution of county COVID-related policies across 250 counties nationwide. We will also assess whether these policies affected mental health and healthcare utilization among vulnerable groups like racial/ethnic minorities and low-income people.

PI_NAMEs: HAMAD, RITA  (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Acute;Address;Adult;Adverse effects;Affect;Alcohol consumption;American;Anxiety;behavioral health;Behavioral Risk Factor Surveillance System;Black race;Businesses;Catalogs;Collaborations;Contact Tracing;Containment;County;County Government;COVID-19;COVID-19 pandemic;Data;Data Set;Databases;Disparity;Disparity population;Documentation;Drug usage;Economic Policy;Economics;Ensure;ethnic disparity;ethnic minority;Ethnic Origin;experience;Experimental Models;falls;Family;Financial Hardship;geographic difference;Geography;Goals;Health;Health behavior;health care disparity;health care service utilization;health disparity;Health Expenditures;Health Policy;Health Services Accessibility;Health Surveys;high risk population;Home;Household;Housing;illicit drug use;Income;Individual;Inequity;Intervention;Job loss;Latinx;Lead;Leadership;Link;long-standing disparities;Low income;Low Income Population;Measures;Medicaid;medical specialties;Mental Depression;Mental Health;Mental Health Services;Minority Women;National Health Interview Survey;Occupations;Outcome;Outcomes Research;pandemic disease;pandemic impact;Patient Self-Report;people of color;Persons;Policies;Policy Making;Population;Poverty;Primary Care;psychological distress;Public Health;public health intervention;Quasi-experiment;Race;racial disparity;racial minority;Reporting;Research;Research Personnel;Resources;Rural;Sampling;Services;Smoking;social determinants;social health determinants;Social Policies;socioeconomic disparity;Socioeconomic Status;socioeconomics;Source;Stress;Subgroup;Surveys;Testing;trend;Unemployment;urban residence;Vaccination;Variant;vulnerable community;Vulnerable Populations;Work

PROJECT_TITLE: The Impacts of County-Level COVID- 19 -Related Public Health and Social Policies on Racial/Ethnic and Socioeconomic Disparities in Mental Health and Healthcare Utilization


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BRONX

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Narrative Human tryptophan dioxygenase (hTDO) and indoleamine 2,3-dioxygenase 1 (hIDO1) are two important hemeproteins that are associated with numerous human diseases. This research program aims to delineate three newly discovered enzymatic activities of these proteins. It is relevant to public health because it will advance our understanding of how these proteins contribute to human health and disease.

PI_NAMEs: YEH, SYUN-RU  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: absorption;Accounting;Active Sites;Apoproteins;Binding;Biological Assay;Chemicals;Chemistry;Collaborations;Communication;Comprehension;Consumption;Coupled;Cytochrome P450;Data;Dioxygenases;Disease;disorder control;disorder prevention;Distal;Drug Targeting;Electron Transport;Electrons;Electrostatics;Environment;experimental study;Flavin Mononucleotide;Goals;Guidelines;Health;Heme;heme a;Hemeproteins;Histidine;Human;Human Activities;human disease;Hydrogen Peroxide;insight;Kinetics;Knowledge;Kynurenine;Malignant Neoplasms;Mass Spectrum Analysis;Mediator;molecular dynamics;Mutagenesis;novel;Oxidases;Oxygen;Oxygenases;Peroxidases;Physiological;pressure;Process;programs;Property;Proteins;Protons;Public Health;Raman Spectrum Analysis;Reaction;Research;Serine;simulation;Solvents;Spectrum Analysis;structural determinants;Structure;Superoxides;Techniques;Testing;Therapeutic;Time;Tryptophan;Tryptophan 2,3 Dioxygenase;Water;Work;X-Ray Crystallography

PROJECT_TITLE: Expanding the Catalytic Repertoire of Heme-based Dioxygenases

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: DALLAS

ORG_DEPT: PATHOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Alzheimer's disease (AD) is a leading cause of dementia interfering with daily life. Unfortunately, no effective treatment is available to prevent AD dementia progression so far. The goals of this project are to discover the essential functions and comprehensive molecular understanding of epigenetic dysregulation in cognitive deficits and AD pathogenesis.

PI_NAMEs: WANG, YINGFEI  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: abeta accumulation;Address;Age Months;Aging;aging brain;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease related dementia;Animals;APP-PS1;Behavioral;Brain;Cell Death;Clinical Research;Cognition;Cognitive deficits;cognitive function;conditional knockout;Dementia;density;Development;Diamond;Disease;Disease Progression;effective therapy;Electrophysiology (science);Ensure;Epigenetic Process;epigenetic regulation;excitatory neuron;Exhibits;experience;Foundations;Functional disorder;Gene Expression;Genes;Glutamate Transporter;Glutamates;Goals;Heterozygote;Hippocampus;Histone H3;Histones;Human;hyperphosphorylated tau;Impaired cognition;improved;In Vitro;in vivo;innovation;knock-down;Knockout Mice;Knowledge;Late Onset Alzheimer Disease;Learning;Life;Loss of Heterozygosity;Lysine;Mediator;Memory impairment;Memory Loss;Molecular;mouse model;Mus;neglect;Nerve Degeneration;neuron loss;Neurons;Neurotransmitters;novel;Nuclear Translocation;Pathogenesis;Pathologic;Pathologist;Pathology;Phosphorylation;Physiological;presynaptic;prevent;promoter;Protein Isoforms;Proteins;recruit;Regulation;Research;Role;Site;success;Synapses;Synaptic plasticity;Synaptic Vesicles;tau aggregation;tau dysfunction;tau interaction;tau Proteins;tau-1;therapeutic target;uptake;Vertebral column;Vesicle;Work

PROJECT_TITLE: Role of KDM6B in Alzheimer’s disease related dementia

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Back Pain;Chronic Pain;Estrogen;Pain Research;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: ORTHOPEDICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Aged individuals are prone to intervertebral disc degeneration and there is no intermediary treatment between palliative care and invasive surgery to stem its progression. We propose to clarify the molecular mechanisms underlying intervertebral disc degeneration and to establish the promising viability of FDA-approved bone prophylactics anti-sclerostin antibody and raloxifene to reverse/attenuate intervertebral disc degeneration in aged mice. Completion of this proposal will (1) bolster the potentially safe application of pharmacological therapeutics in the elderly for whom habitual maintenance of the spine by strenuous exercise can be limited and (2) will potentially prolong the need for invasive surgery.

PI_NAMEs: HOLGUIN, NILSSON  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Acute;Adult;Affect;Age;age related;aged;Aging;aging population;Agonist;Anabolism;analog;antagonist;Antibodies;Attenuated;Back Pain;Behavior;Behavioral Model;beta catenin;Binding;Biophysics;bone;bone mass;Bone structure;Cell Proliferation;Cells;Child;chronic pain;Collagen;Collection;Data;Dehydration;disability;Dose;Early treatment;Economic Burden;Elderly;Ensure;ESR1 gene;Estrogens;Etiology;Extracellular Matrix;FDA approved;Female;Generations;Genetic;Genetic Recombination;Glycine decarboxylase;Height;Histology;Homeostasis;Hydration status;Impairment;improved;Inflammation;inhibitor;Injections;Intervertebral disc structure;intervertebral disk degeneration;Knowledge;LacZ Genes;Ligands;Low Back Pain;LoxP-flanked allele;Magnetic Resonance Imaging;Maintenance;male;mechanical force;Mechanics;Mediating;men;Metabolism;Modeling;Molecular;Mus;Natural regeneration;nucleus pulposus;Occupations;old mice;Older Population;Operative Surgical Procedures;Osteogenesis;Outcome;Ovariectomy;overexpression;Pain;pain behavior;palliative;Palliative Care;Pathway interactions;Persons;pharmacologic;Population;Positioning Attribute;Postmenopause;prevent;Prevention;Property;prophylactic;Proteoglycan;Raloxifene;Recording of previous events;Reporter;response;second harmonic;sex;Signal Pathway;Signal Transduction;socioeconomics;spinal disk injury;Statistical Data Interpretation;stem;Strenuous Exercise;Structure;Substance P;Tail;Tamoxifen;Testing;Therapeutic;Time;transcription factor;transcriptome sequencing;Vertebral column;Water;WNT Signaling Pathway;Woman;young adult

PROJECT_TITLE: Repurpose bone therapeutics for intervertebral disc degeneration in aged mice

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative This project will optimize the dosing concentration and timing of treatment initiation of a promising, novel, orally available TREM2 (Triggering receptor expressed on myeloid cells 2) activating compound, Sob-AM2. It will also evaluate the effects of TREM2 activation by oral Sob-AM2 on Alzheimer's disease (AD) pathology, cognitive function and neuroinflammation using mouse models of beta-amyloid accumulation and tauopathy. By conducting these essential preclinical experiments, this project will provide critical information about the therapeutic utility of this recently discovered drug for use in AD.

PI_NAMEs: GRAY, NORA  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: abeta accumulation;Acceleration;age acceleration;Agonist;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapy;Amides;Amyloid beta-42;Amyloid beta-Protein;Animals;Anti-Inflammatory Agents;Antibodies;Biological Markers;Blood;Blood - brain barrier anatomy;Brain;brain tissue;C57BL/6 Mouse;Central Nervous System;Cerebrospinal Fluid;Chromatography;clinical translation;Cognition;cognitive function;cognitive testing;comparison control;cytokine;Demyelinations;design;Diet;Disease;disease model;Disease Progression;dosage;Dose;drug candidate;Drug Kinetics;Drug Targeting;Drug usage;efficacy evaluation;Enzyme-Linked Immunosorbent Assay;Event;Experimental Autoimmune Encephalomyelitis;experimental study;Female;Gene Expression;Genes;glial activation;Harvest;hormonal signals;Human;Immunohistochemistry;Impaired cognition;improved;Inflammatory;inflammatory marker;Inflammatory Response;Integral Membrane Protein;interest;Late Onset Alzheimer Disease;Light;Liquid substance;Macrophage;male;Mass Spectrum Analysis;Mediating;Medicine;member;Microglia;Missense Mutation;Modeling;Monitor;mouse model;Multiple Sclerosis;Mus;National Institute on Aging;Nerve Degeneration;Neurodegenerative Disorders;neurofilament;neuroinflammation;neuroprotection;new therapeutic target;novel;novel therapeutics;Oral;overexpression;Parents;Pathogenesis;Pathology;Pathway interactions;Patients;Performance;Peripheral;Permeability;Phagocytosis;Pharmaceutical Preparations;Phase;Phenotype;Phosphorylation;Play;pre-clinical;preclinical study;Preclinical Testing;Prodrugs;Production;Property;Proteins;receptor;Rodent Model;Role;Serum;Severity of illness;side effect;Signal Transduction;small molecule;Spinal Cord Lesions;targeted treatment;tau Proteins;Tauopathies;Therapeutic;Therapeutic Intervention;Thyroid Hormone Receptor;Thyroid Hormones;Toxic effect;transcriptome sequencing;treatment duration;TREM2 gene;Triiodothyronine;Wild Type Mouse;Wit;Work

PROJECT_TITLE: Evaluating a novel, orally-active TREM2-targeting drug in AD


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Primary Immunodeficiencies;Rare Diseases

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NK cell deficiency (NKD) patients have abnormal NK immune cell defenses, leading to severe viral infections, cancer, and often death. We have assembled the world’s largest group of NKD patients and, using advanced genomic, analytic, and NK cell biological techniques, have discovered over 12 gene mutations responsible for their disease. This grant aims to identify more NKD genes and in so doing learn more about how NK cells work and protect us from disease.

PI_NAMEs: ORANGE, JORDAN SCOTT (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Abnormal Cell;Acceleration;advanced analytics;Affect;Alleles;Biological;Biometry;Candidate Disease Gene;candidate identification;Caring;CD34 gene;cell killing;Cell Line;Cell model;Cell Physiology;Cells;Cellular biology;Cellular Structures;Cessation of life;Clinical;cohort;Collaborations;college;Complex;Computer Analysis;congenital immunodeficiency;Cytoprotection;data lake;Databases;Defect;Development;Diagnosis;Disease;Enrollment;Etiology;Evaluation;exome sequencing;functional genomics;Funding;Future;Gene Mutation;Genes;Genetic;Genetic Diseases;genome sequencing;Genomic medicine;Genomics;Genotype;Goals;Grant;Health;Human;Image;Immune;Immunity;immunodeficiency;Immunologics;Impairment;improved;Infrastructure;insight;interest;International;Investigation;Knowledge;Laboratories;Learning;Malignant Neoplasms;MCM10 gene;Mechanics;Medicine;Methods;Natural History;Natural Killer Cells;novel;participant enrollment;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phenotype;phenotypic data;Positioning Attribute;Predisposition;Prognosis;programs;Proteins;recruit;Research;success;Systems Development;Techniques;Testing;Therapeutic;transcriptome sequencing;Variant;Virus;Virus Diseases;whole genome;Work

PROJECT_TITLE: GENETIC, IMMUNOLOGIC AND MECHANISTIC BASIS OF HUMAN NK CELL DEFICIENCY

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Rare Diseases

PHR: PROJECT NARRATIVE Most cancer patients die when their tumors “progress” by metastasizing or becoming resistant to therapy. We developed techniques to study tumor metabolism directly in patients, and as a result discovered metabolic properties that promote cancer progression and early death. We will now 1) block these pathways to prolong survival in mouse models of cancer; 2) develop methods to discover more metabolic properties that drive cancer progression in patients and could be blocked with new therapies; and 3) use a unique orthogonal approach based on rare genetic diseases to discover how some metabolic defects prime cells to become malignant.

PI_NAMEs: DEBERARDINIS, RALPH J (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Advanced Malignant Neoplasm;Biochemical Pathway;Biopsy;cancer initiation;Cancer Model;Cancer Patient;Cells;Cessation of life;Citric Acid Cycle;Clear cell renal cell carcinoma;Clinical;cohort;Data;Defect;Dependence;Electron Transport;Excision;experimental study;Glucose;Human;imaging modality;Inborn Errors of Metabolism;Infusion procedures;insight;Isotope Labeling;Isotopes;Kidney;Label;Malignant - descriptor;Malignant Neoplasms;Measures;Metabolic;metabolic abnormality assessment;Methodology;Methods;mitochondrial metabolism;mouse model;Mus;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;novel therapeutics;Nutrient;Oxidative Phosphorylation;Pathway interactions;Patient-Focused Outcomes;Patients;Physiological;Procedures;Productivity;Property;rare genetic disorder;Sampling;Series;Site;Source;Stable Isotope Labeling;success;Techniques;therapeutic target;therapy resistant;Time;Tracer;tumor;tumor metabolism;tumor progression;Variant;Work

PROJECT_TITLE: Human metabolic variation as a window into cancer initiation and progression


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PUBLIC HEALTH BENEFIT  This proposal will develop a new therapy that will help to cure drug-susceptible and drug-resistant forms of tuberculosis. It will also have the potential to reduce the length of time need to treat tuberculosis and inhibit new resistance from occurring. If our research goals are achieved, the novel therapy would be an important step towards the global eradication of tuberculosis.

PI_NAMEs: FREUNDLICH, JOEL STEPHEN (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Acute;Amides;Anabolism;analog;animal efficacy;Applications Grants;azetidine;Binding;Biological;Biophysics;Butane;Cell Death;Cell Wall;Cessation of life;Chronic;Clinical;clinical candidate;clinically relevant;Collaborations;combinatorial;Companions;Comprehension;Data;Development;Dose;Drug Combinations;drug development;drug discovery;Drug Kinetics;drug relapse;Drug resistance;Drug resistance in tuberculosis;Drug Targeting;Enzymes;Essential Genes;Exhibits;experience;experimental study;extensive drug resistance;fatty acid biosynthesis;Friends;Generations;global health;Goals;Grant;Health Benefit;improved;In Vitro;in vitro activity;in vivo;Indoles;Infection;inhibitor;isoniazid;Lead;Length;machine learning model;Measurable;Microbiology;Modeling;Multi-Drug Resistance;Mus;Mycobacterium tuberculosis;Mycolic Acid;nanomolar;novel;novel therapeutics;Oral;pandemic disease;Pathogenesis;Pathway interactions;Performance;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;Pharmacotherapy;pre-clinical;preclinical development;Predisposition;Probability;Process;programs;Public Health;Publishing;Regimen;Reporting;Research;Research Personnel;Resistance;resistant strain;Resolution;Rifampin;risk minimization;risk selection;Roentgen Rays;Route;Series;skills;structural biology;Structure;Sulfonamides;Sum;targeted treatment;therapy duration;Time;Treatment Failure;Treatment Protocols;Tuberculosis;tuberculosis drugs;tuberculosis treatment;United States;Validation;X-Ray Crystallography

PROJECT_TITLE: A Preclinical Program for Targeting Mycobacterium tuberculosis KasA

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: MADISON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The replication stress response is required to repair DNA lesions that arise due to both endogenous sources and environmental genotoxins found in water, food, and industrial chemicals. This proposal aims to discover how the replication-coupled protein HMCES protects cells from genomic instability and mutation (K99) and more broadly how DNA-strand specific obstacles contribute to mutagenesis (R00). Completing this proposal will characterize how cells prevent mutagenesis in a new context uncovering mechanisms in DNA repair.

PI_NAMEs: MEHTA, KAVI  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: 4-Hydroxy-Tamoxifen;adduct;Aging;Agrochemicals;Air Pollution;Alkylating Agents;Aromatic Amines;Aromatic Polycyclic Hydrocarbons;Bacillus subtilis;base;Binding;biological adaptation to stress;Biological Assay;Biological Models;Bypass;career;Cell Nucleus;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Copy Number Polymorphism;Coupled;CRISPR screen;crosslink;Cysteine;Cytidine Deaminase;Cytoprotection;Cytosine;Data;Deamination;deep sequencing;developmental disease;DNA;DNA biosynthesis;DNA lesion;DNA Repair;DNA Sequence Rearrangement;DNA-(apurinic or apyrimidinic site) lyase;DNA-Directed DNA Polymerase;DNA-protein crosslink;endonuclease;environmental toxicology;Estrogen Receptors;Event;exome sequencing;Food;Foundations;Frequencies;Future;Genetic;Genome Stability;Genomic Instability;Genomics;Goals;Human;Hyperactivity;Industrialization;inhibitor;innovation;insertion/deletion mutation;Institution;Learning;lens;Lesion;Malignant Neoplasms;Mammalian Cell;Methods;multicatalytic endopeptidase complex;Mutagenesis;Mutagens;mutant;Mutation;N-terminal;oxidation;Pathway interactions;Peptide Hydrolases;Pharmaceutical Preparations;Phase;Plasmids;Polymerase;prevent;Principal Investigator;Process;protective pathway;Proteins;recruit;repaired;replication stress;Research;response;Series;Signal Transduction;Single-Stranded DNA;Site;Source;Specific qualifier value;Specificity;Stress;System;Testing;Toxic Environmental Substances;Toxin;Training;Uracil;uracil-DNA glycosylase;Water;Work

PROJECT_TITLE: The mutagenic consequences of replication-coupled DNA repair mechanisms

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Increasing evidence reveals that the metabolic health of mammals is particularly vulnerable to a variety of environmental stressors. Understanding the nature of the "sperm RNA code" for various environmental stressors that confer intergenerational transmission of metabolic disorders may not only satisfy scientific interest, but also hold promise to move the field towards translational applications and precision medicine facing the obesogenic environment.

PI_NAMEs: CHEN, QI  (contact);ZHOU, TONG

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Arsenic;Arsenites;Biogenesis;Bioinformatics;Biological;Cells;Code;comparative;Comparative Study;Complex;Computer software;Data;Diet;DNA Modification Methylases;Embryo;Embryonic Development;Endocrine Disruptors;Environment;Environmental Exposure;environmental stressor;Enzymes;Exposure to;Future;Genetic Transcription;Genets;glucose metabolism;Health;Heterogeneity;High Fat Diet;improved;Individual;Inherited;Injections;interest;intergenerational;Knowledge;Lead;Ligation;lipid metabolism;Liquid Chromatography;male;Mammals;Masks;Maternal Exposure;Mediating;Messenger RNA;Metabolic;Metabolic Diseases;metabolic phenotype;Methods;Methyltransferase;Modification;Molecular;mouse model;Nature;novel;Obesity;obesogenic;offspring;Oxidative Stress;Pathologic Processes;Performance;Phenotype;Physiological;precision medicine;programs;Property;Protocols documentation;ribosome profiling;Ribosomes;RNA;RNA-Directed DNA Polymerase;Science;Site;Small RNA;Specificity;sperm cell;tandem mass spectrometry;Testing;Therapeutic Intervention;transcriptome sequencing;transcriptomics;Transfer RNA;Translating;translational applications;transmission process;tributyltin;Untranslated RNA

PROJECT_TITLE: Decoding the signature of sperm RNA & RNA modification of environmental stressors on the intergenerational transmission of metabolic phenotypes

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Narrative West Virginia bears many historical, physical, psychosocial, and fiscal burdens brought about by a multitude of issues – high levels of chronic diseases, the opioid crisis, environmental risk factors and economic trends. The West Virginia Pediatric Clinical Trials Network (WVPCTN) as a Clinical Site of the ECHO IDeA States PCTN (ISPCTN) has truly been a catalyst for addressing some of these burdens by fulfilling its two-fold mission in our IDeA state of West Virginia – bringing clinical trials to our underserved population and building professional capacity for clinical research. Together with strong and sustained partnerships throughout the state, and the multiple environmentally related conditions of our citizens, WVU continues to be uniquely positioned to be successful as an ISPCTN Clinical Site and add to a long-standing commitment to Pediatric focused initiatives across the state.

PI_NAMEs: JAYNES, MARGARET  (contact);PYLES, LEE A;SAUL, J PHILIP

PROGRAM_OFFICER_NAME: RAJU, TONSE N

PROJECT_TERMS: Acceleration;Acute;Address;Appalachian Region;Behavior Therapy;catalyst;Characteristics;Child;Child Health;Childhood;Chronic;Chronic Disease;clinical investigation;Clinical Research;clinical research site;Clinical Sciences;clinical translation;Clinical Trials;Clinical Trials Network;Collaborations;Dedications;Disease;Disparity;Economics;Effectiveness;Environment;Environmental Risk Factor;experience;Faculty;follow-up;Fostering;Funding;Goals;Health;Human Resources;Hypertension;in utero;Infant;Infrastructure;insight;interest;Intervention;Lead;Leadership;Mentors;Methods;Mission;Multicenter Trials;Neonatal Abstinence Syndrome;neonate;opioid epidemic;opioid exposure;Outcome;Pediatric Research;Performance;Positioning Attribute;Prevention;psychosocial;Qualifying;recruit;Research;Research Infrastructure;Research Personnel;Resources;Rural Population;rurality;Site;skills;Standardization;Structure;success;Teacher Professional Development;tool;Training;Translational Research;trend;Underserved Population;West Virginia;Work

PROJECT_TITLE: West Virginia Pediatric Clinical Trials Network-2


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Type 2 diabetes is a growing public health concern associated with increased risk of heart failure. However, there are limited strategies to identify which patients with type 2 diabetes may benefit from preventive therapies such as intensive blood pressure control. We propose to measure N-terminal pro-B-type natriuretic peptide and high-sensitivity cardiac troponin T from blood stored by the NHLBI Biorepository of participants enrolled in the ACCORD-BP trial to evaluate whether a biomarker-based approach can inform intensive blood pressure control treatment decisions among high-risk adults with type 2 diabetes to prevent heart failure.

PI_NAMEs: PANDEY, AMBARISH  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Adult;Affect;American;Attenuated;Behavior;biobank;Biological Markers;Blood;Blood Pressure;blood pressure control;Blood specimen;blood-based biomarker;Brain natriuretic peptide;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cause of Death;Clinical;Clinical Trials;Cohort Studies;Consensus;control trial;Data;design;Diabetes Mellitus;effective therapy;Enrollment;Epidemiology;epidemiology study;Event;Exclusion;experience;follow-up;Goals;Growth;healthy lifestyle;Heart failure;high risk;high risk population;Hypertension;Incidence;Individual;Injury;Letters;Measurement;Measures;Morbidity - disease rate;mortality;Myocardial;Myocardial Ischemia;N-terminal;National Heart, Lung, and Blood Institute;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Outcome;Participant;participant enrollment;Patients;personalized approach;Phenotype;Prevalence;prevent;Prevention;Prevention strategy;preventive intervention;Preventive therapy;prognostic;Public Health;Recommendation;Reporting;Risk;Risk Assessment;Risk Factors;risk prediction;Risk Reduction;Role;secondary analysis;societal costs;Stress;Subgroup;Testing;treatment effect;treatment trial;trend;Troponin T;United States;Work

PROJECT_TITLE: Cardiac biomarkers, intensive blood pressure treatment and risk of adverse cardiovascular outcomes in type 2 diabetes, a secondary analysis of the ACCORD BP


NIH_SPENDING_CATS: Lung

ORG_CITY: Columbus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Sensing and discrimination of foreign vs host nucleic acids is key for providing protection against pathogens while preventing autoimmunity. The nucleic acid sensors known as retinoic acid inducible gene I (RIG-I)-like receptors (RLRs) are critical to regulating pulmonary inflammation, protection from damage, and repair, but the roles for RLRs in discrete cell types and tissue microenvironments remains unknown. This R35 research program will utilize novel RLR (RIG-I and MDA5) genetic knockout murine lines to unravel the unique roles of the RLRs in regulating pulmonary homeostasis, pathology, and tissue repair.

PI_NAMEs: HEMANN, EMILY ANN (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TITLE: RIG-I-like receptor regulation of pulmonary inflammation and homeostasis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Cannabidiol Research;Cannabinoid Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Natural Products;Rare Diseases;Therapeutic Cannabinoid Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as it will study the mechanism by which Cannabidiol (CBD) ameliorates Acute Respiratory Distress Syndrome (ARDS). Elucidating the mechanism for a natural therapeutic to treat ARDS is vital to advance COVID-19 and Sepsis research.

PI_NAMEs: WILSON, KIESHA  (contact)

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;Advisory Committees;Affect;Alveolar;alveolar destruction;Alveolar Macrophages;American;Amino Acid Sequence;Anti-Inflammatory Agents;Apoptotic;Attenuated;attenuation;Bacteria;Biological Assay;Biological Markers;Biological Models;Biometry;C3H/HeJ Mouse;Cannabidiol;Cannabinoids;Cannabis;career development;CCAAT-Enhancer-Binding Proteins;CCL17 gene;CD14 gene;Cell Line;cell type;Cells;Cellular Infiltration;Characteristics;chemokine;Clinical;Coronavirus;COVID-19;COVID-19 mortality;COVID-19 patient;CRISPR/Cas technology;CXCL9 gene;cytokine;cytokine release syndrome;Data;Disease;DNA;Drops;Endothelial Cells;Environment;Epigenetic Process;Epithelial Cells;Evaluation;FCGR3B gene;Gene Activation;Gene Expression;Genes;Genetic;Genetic Transcription;Human;Hypoxia;Immune;Immunologics;in silico;in vivo;Infection;Infiltration;Inflammatory;Inflammatory Response;Inhalation;insight;Interleukin-1 beta;Interleukin-12;interleukin-23;Interleukin-6;Liquid substance;Lung;Macrophage;Macrophage Activation;Marijuana;Mediating;Mentors;MicroRNAs;migration;Modeling;monocyte;Mononuclear;Multiple Organ Failure;Mus;myeloid cell development;neutrophil;Overdose;pandemic disease;pathogen;Pathway Analysis;Patients;Persons;Phagocytosis;phytocannabinoid;Plants;Play;Plethysmography;Prevention strategy;Preventive;promoter;Property;protein structure;Public Health;pulmonary function;Pulmonary Inflammation;Quantitative Reverse Transcriptase PCR;receptor;Reporter;Research;Research Personnel;Role;SARS-CoV-2 spike protein;sedative;Sepsis;severe COVID-19;Severity of illness;single cell sequencing;single-cell RNA sequencing;Site;South Carolina;Stains;Staphylococcal Enterotoxin B;Structure;Superantigens;Survival Rate;Testing;Tetrahydrocannabinol;Therapeutic;therapeutic development;TNF gene;Toxin;Training;transcription factor;Trauma;Universities;Up-Regulation;Virus

PROJECT_TITLE: Role of Macrophages in CBD mediated attenuation of SEB-induced ARDS


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Given the enormous amount of data generated by research studies and in the clinic today, visualization is often a key element in gaining insight into the genomic basis and mechanisms of disease. These insights will help to develop hypotheses for further study, guide treatment, and point the way to new therapeutic targets. We propose to ensure that the Integrative Genomics Viewer (IGV) continues to track and respond to advances in genomics technology and changing user needs, and maintains its high level of utility for the cancer research community.

PI_NAMEs: MESIROV, JILL P. (contact);ROBINSON, JAMES THOMAS

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Architecture;base;Bioinformatics;cancer genomics;cancer therapy;Clinic;Clinical;clinical sequencing;cloud based;Code;Collaborations;Communities;Complex;Computer software;computerized data processing;Data;data acquisition;data platform;data visualization;Development;Disease;Documentation;Electronic Mail;Elements;Emerging Technologies;Ensure;Environment;Event;Evolution;Exercise;experience;family support;flexibility;Future;Generations;genome resource;genomic data;genomic tools;Genomics;Goals;improved;insight;interoperability;Java;Letters;Libraries;light weight;Link;Malignant Neoplasms;Methods;new technology;new therapeutic target;novel;Nucleotides;open source;Operating System;Patients;Performance;precision oncology;programs;Publications;Reporting;Research;Research Personnel;research study;Resources;response;Software Engineering;Software Tools;success;Suggestion;Technology;tool;Training;Treatment Protocols;tumor;Update;usability;user-friendly;Validation;Variant;Visual;Visualization;Walking;web app;Work

PROJECT_TITLE: The Integrative Genomics Viewer (IGV) for Cancer Research


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Human Genome;Liver Disease

PHR: Non-alcoholic steatohepatitis (NASH) is the most common liver disease in the U.S. and progresses to liver fibrosis. Hepatic Stellate Cells (HSCs) that normally exhibit a quiescent phenotype (qHSCs) and store Vitamin A, activate into Collagen Type I-expressing aHSCs/myofibroblasts in response to metabolic liver injury to produce the fibrous scar. Phenotypic changes in HSCs occur without a change in the DNA sequence but are regulated on an epigenetic level (e.g. specific modifications in the chromatin structure), characterization of the gene expression and epigenetic changes specific for primary human HSCs isolated from normal, and NASH livers will identify new targets for antifibrotic therapy.

PI_NAMEs: BRENNER, DAVID A.;KISSELEVA, TATIANA  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Ablation;Acetylation;activating transcription factor 3;Affect;Amino Acid Motifs;antifibrotic treatment;Apoptosis;Area;ATAC-seq;Bar Codes;Binding;Cell Differentiation process;Cell Nucleus;Cell Separation;Cells;Cellular Assay;Centrifugation;Characteristics;ChIP-seq;Chromatin;Chromatin Structure;Chronic;Cicatrix;Cluster Analysis;Collaborations;Collagen;Collagen Type I;combinatorial;Data;Diphtheria Toxin;diphtheria toxin receptor;DNA;DNA Sequence;EGR2 gene;Enhancers;Epigenetic Process;epigenome;Exhibits;Experimental Models;Extracellular Matrix;Fibrosis;Gene Expression;Gene Expression Profile;gene repression;Genes;Genetic;Genetic Enhancer Element;genetic signature;Genetic Transcription;genome wide association study;genome-wide;genomic locus;Glass;Hepatic Stellate Cell;Heterogeneity;histone modification;Human;human tissue;Immunoprecipitation;In Vitro;in vivo;Individual;Injury;insight;knock-down;Knock-in;Knock-out;knockout gene;Knockout Mice;Laboratories;Liver;Liver diseases;Liver Fibrosis;liver injury;liver transplantation;Location;LoxP-flanked allele;Luciferases;Mediating;Metabolic;Modification;Monitor;mouse model;Mus;Myofibroblast;non-alcoholic fatty liver;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel strategies;Nuclear;overexpression;Pathogenesis;Patients;pharmacologic;Phenotype;Physiological;Play;Population;prevent;promoter;Property;Regulation;Regulatory Element;Regulatory Pathway;Reporter;response;Risk Factors;risk variant;Role;sex;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;small hairpin RNA;Sorting;Technology;Testing;Tissues;transcription factor;Transcriptional Activation;transcriptome;Transplantation;treatment effect;Vitamin A;western diet;Xenograft procedure

PROJECT_TITLE: Epigenetics of human Hepatic Stellate Cells (HSCs) in NASH

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CLEVELAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Methods to regenerate photoreceptors represents a major therapeutic goal for inherited retinal disease. Zebrafish have the capacity to regenerate lost neurons following acute injury but mutants with retinal degeneration do not regenerate. This proposal will address critical unanswered questions such as why zebrafish with chronic inflammation in diseased retinas fail to regenerate and to determine how inflammation regulates regeneration.

PI_NAMEs: PERKINS, BRIAN D (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: 1 year old;Acute;Address;Animals;ATAC-seq;Blindness;Cell Cycle;Cell Death;cell regeneration;Cells;Cessation of life;Chronic;Chronic Disease;ciliopathy;Cone;CRISPR/Cas technology;cytokine;Cytokine Signaling;Data;Disease;disease model;epigenomics;Exhibits;Gene Expression;gene regulatory network;Genetic;Genetic Diseases;Gliosis;Goals;Human;human model;IL6 gene;Immune response;Immunosuppression;Inflammation;Inflammatory;Inflammatory Response;Inherited;inherited retinal degeneration;Injury;insight;Lesion;Ligands;Light;Link;Literature;Macrophage;Mammals;Methods;Microglia;Modeling;Molecular;Muller's cell;multiple omics;mutant;Natural regeneration;nerve stem cell;Neurons;NF-kappa B;notch protein;NOTCH3 gene;novel;Pathway interactions;pharmacologic;Phase;photoreceptor degeneration;Photoreceptors;prevent;Process;programs;Proliferating;receptor;regenerative;Regenerative research;Regenerative response;Repression;Resolution;response;Retina;Retinal Degeneration;Retinal Diseases;Retinal Dystrophy;retinal neuron;retinal progenitor cell;retinal regeneration;Retinitis Pigmentosa;Role;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Source;stem cell proliferation;stem-like cell;Technology;Testing;Therapeutic;Time;TNF gene;Translating;Up-Regulation;Vision;Zebrafish

PROJECT_TITLE: Inflammatory Signaling and Regeneration in Zebrafish models of Retinal Degeneration

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Projective Narrative Emotion-based impulsivity, which involves difficulties with emotion regulation and cognitive control, is a debilitating and understudied problem in bipolar spectrum disorders. This study will use advanced neurophysiological measurement and ecological momentary assessment to examine whether neural oscillations underlying response inhibition are associated with emotion regulation and impulsivity in daily life. The resulting data may help to identify novel treatment targets for emotion-based impulsivity in bipolar spectrum and related disorders.

PI_NAMEs: SPERRY, SARAH HAVENS (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acceleration;Adult;Affective;affective neuroscience;Area;Arousal;Behavior;Behavioral;Bipolar Disorder;bipolar spectrum;Brain;brain based;Brain region;candidate identification;Clinical;Clinical Sciences;clinical translation;Cognition;Cognitive;cognitive control;cognitive process;Cognitive Therapy;Communication;Complex;Coupling;Data;design;Development;Diagnosis;Dimensions;Disease;Distal;Ecological momentary assessment;effective intervention;Electroencephalography;emotion regulation;emotional stimulus;Emotions;Enrollment;Environment;Evolution;executive function;experience;Frequencies;Functional Magnetic Resonance Imaging;Goals;Hospitalization;improved;Impulsivity;indexing;Individual;innovation;Intervention;Investigational Therapies;K-Series Research Career Programs;Life;Link;Longitudinal cohort;Measurement;Measures;Mentors;Methods;Michigan;Modeling;Moods;multimodality;National Institute of Mental Health;negative affect;neural;Neurons;neurophysiology;neuroregulation;Neurosciences Research;novel;Outcome;Participant;Patient Self-Report;personalized intervention;Persons;Phase;Process;programs;Protocols documentation;Psychopathology;psychosocial;recruit;Reporting;Research;Research Domain Criteria;response;responsible research conduct;Role;Sampling;Signal Transduction;substance use;Substance Use Disorder;Suicide;Testing;Therapeutic Trials;Time;Training;trait;Translating;Translational Research;Universities;Work

PROJECT_TITLE: Affective and Cognitive Mechanisms of Emotion-Based Impulsivity in Bipolar Disorder: Linking Neural Oscillatory Dynamics to Real-World Outcomes

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Prevention

ORG_DEPT: MISCELLANEOUS

PHR: Project Narrative Family caregivers are essential to the nation’s well-being and economy yet little information exists regarding the daily lives of ADRD and non-ADRD caregivers across the diverse social partners who provide care. The present study develops and administers new survey instruments in the Understanding America Study (UAS) to identify caregivers and implements new daily assessments and wearable devices to capture caregivers’ daily experiences and their links with daily emotional and physiological well-being among ADRD and non-ADRD family and non-family caregivers ranging in age from young adulthood to old age. Understanding daily experiences and reactivity and the factors that predict greater resilience and vulnerability to stress in a national sample of caregivers will provide unprecedented information regarding potentially modifiable risk and protective factors for improving caregiver health and well-being.

PI_NAMEs: ANGRISANI, MARCO ;BIRDITT, KIRA S (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, JOHN

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Age;age group;Alzheimer's disease related dementia;American;Behavior;Biometry;Buffers;care recipients;Caregivers;caregiving;Caring;Cellular Phone;Child;Communities;Coping Skills;cost;Data;Data Collection;Data Set;Dementia caregivers;digital technology;disability;disabled;Eating;Ecological momentary assessment;Emotional;Exhibits;expectation;experience;Extended Family;Family;Family Caregiver;Financial Hardship;fitbit;Future;Generations;Health;Health behavior;health data;Heart Rate;heart rate variability;human old age (65+);improved;Individual;informal caregiver;informal caregiving;Internet;Life;Life Cycle Stages;Link;Long-Term Care;Longitudinal Studies;machine learning method;Measures;Mental Health;modifiable risk;nonalzheimer dementia;older adult;Outcome;Participant;Patient Self-Report;Personal Satisfaction;Persons;Phase;Physical activity;physical conditioning;Physiological;Predictive Factor;Probability;Productivity;protective factors;psychosocial resources;Reporting;Research;resilience;resilience factor;Respondent;Risk Factors;Role;Sampling;Sleep;smartphone application;Smoking;social;social relationships;socioeconomics;Spouses;statistical and machine learning;Stepfamilies;Stress;stress reactivity;Surveys;Time;tool;Underrepresented Populations;wearable device;Work;young adult

PROJECT_TITLE: UAS-CLEAR: A new nationally representative longitudinal study of caregiving experiences and well-being across the lifecourse

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-A(56)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: SEATTLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative The proposed study investigates how cerebral aneurysm treatment outcome can be predicted through computer simulations. Typical simulations do not account for clotting factors in the blood, which are important in determining which treatments succeed and which fail. We will incorporate these aspects into computer simulations and validate them with an animal model of cerebral aneurysms for cerebral aneurysm treatment outcome prediction. This project has an impact on public health by improving the prevention of hemorrhagic stroke from aneurysm rupture and improving treatment.

PI_NAMEs: LEVITT, MICHAEL ROBERT (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Aftercare;Aneurysm;Animal Model;Animals;Area;Attention;Biological;Blood;Blood Coagulation Factor;Blood flow;Blood Platelets;blood product;Blood Vessels;Brain hemorrhage;Cerebral Aneurysm;cerebral hemodynamics;Clinical;clinical predictors;cohort;Computer Models;Computer Simulation;Decision Making;Devices;direct application;Environment;experience;Failure;Feasibility Studies;Foundations;Funding;Goals;healing;hemodynamics;Histologic;Histology;holistic approach;Human;improved;In Vitro;in vivo;innovation;insight;Liquid substance;Methodology;Methods;Modeling;novel;Oryctolagus cuniculus;Outcome;outcome prediction;particle;Patients;Platelet aggregation;predict clinical outcome;Prevalence;Prevention;Prognosis;Public Health;Radiology Specialty;Recording of previous events;Recurrence;Research;residence;Retreatment;Risk;Role;Rupture;Ruptured Aneurysm;shear stress;simulation;Stents;success;Therapeutic Embolization;Thrombosis;Thrombus;Time;Tissues;Treatment Failure;Treatment outcome;treatment risk;Uncertainty;United States National Institutes of Health;Work

PROJECT_TITLE: Computational modeling of platelets and thrombosis in cerebral aneurysm treatment

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Clinical Research

PHR: PROJECT NARRATIVE Tissue-resident macrophages (TRMs) are vital executives of tissue homeostasis and play important roles in tumors, yet the (metabolic) pathways important for their development, tissue- specific identity, and function are not well understood. Here, we put forward a framework to identify and characterize the metabolic programs overseeing these key aspects of TRM biology, including innovative approaches to explore macrophage metabolism within human tissues. Through these studies, we will obtain a deeper understanding of TRMs across health and disease, and ascertain novel metabolic vulnerabilities that can be exploited for immunomodulation of these essential cells.

PI_NAMEs: PULESTON, DANIEL  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Adoptive Transfer;Adult;Alveolar;Biochemistry;Biology;Bone Marrow;Cardiac;Cell Physiology;cell type;Cells;Cellular biology;Chimera organism;Circulation;Colony-Stimulating Factor Receptors;Development;Disease;Electric Conductivity;Embryo;Embryonic Development;Environment;Enzymes;Excision;GATA6 transcription factor;Generations;Genetic;Genetic Transcription;Growth Factor;Health;Homeostasis;Human;Human Activities;human tissue;hypusine;Immune;immunoregulation;implantation;In Situ;In Vitro;in vitro Assay;in vivo;Infusion procedures;innovation;Knock-out;Lesion;life span;Liver;Macrophage;Maintenance;Malignant neoplasm of ovary;Mass Spectrum Analysis;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modeling;monocyte;mouse model;Mus;mutant;neoplastic cell;novel;novel strategies;Organ;Orthoptics;Parabiosis;pathogen;Pathogenicity;Pathway interactions;Patients;Perfusion;Peritoneum;pharmacologic;Phenotype;Play;Polyamines;Primary carcinoma of the liver cells;programs;Proxy;Pulmonary Surfactants;Role;Route;self-renewal;Shapes;Signal Transduction;System;Technology;Testing;Therapeutic;Tissue Model;Tissues;Tracer;tumor;tumor microenvironment;Tumor-associated macrophages;validation studies;virtual

PROJECT_TITLE: Exploring metabolic governance of immune cell form and function


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hematology;Liver Disease;Nutrition;Rare Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: This project seeks to understand how the body senses and regulates iron-uptake. The uptake of iron into the body needs to be tightly controlled, because too little iron causes anemia and compromised brain development. Complications of too much iron include liver cirrhosis, liver cancer, heart arrythmias, and arthritis.

PI_NAMEs: ENNS, CAROLINE  (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: adeno-associated viral vector;Affinity;Alcoholic Liver Diseases;Anemia;Arrhythmia;Arthritis;Binding;Biological Assay;Biotin;Biotinylation;body sense;Bone Morphogenetic Proteins;Brain;Cardiomyopathies;Cells;Child;Chimeric Proteins;Chronic Hepatitis C;Cirrhosis;Co-Immunoprecipitations;Complex;Cytoplasmic Tail;Dependovirus;Development;Diabetes Mellitus;dietary;dietary control;Dietary Iron;Elements;Equilibrium;exercise intolerance;experimental study;Functional disorder;Gene therapy trial;Genetic Diseases;Goals;Heart;Hemochromatosis;Hepatic;Hepatocyte;hepcidin;Hereditary Disease;Hereditary hemochromatosis;HFE2 gene;Homeostasis;Impairment;In Transferrin;In Vitro;in vivo;Infection;Intervention;Intestines;Iron;iron deficiency;Iron Overload;joint injury;Joints;Knowledge;Lead;Ligase;Liver;Liver Cirrhosis;Malignant neoplasm of liver;Malignant Neoplasms;Mammals;Mass Spectrum Analysis;Mediating;metal transporting protein 1;Modeling;Mus;Mutation;Neurologic;non-alcoholic fatty liver disease;Organ;Organism;Pancreas;Pathologic;Pathway interactions;peptide hormone;Persons;Phosphoproteins;phosphoproteomics;Phosphorylation;Physiological;Play;Population;Proteins;receptor;Regulation;Research;response;Role;Sense Organs;Sickle Cell Anemia;Signal Pathway;Signal Transduction;Source;Streptavidin;Surface Plasmon Resonance;Testing;Thalassemia;Tissues;Transferrin;transferrin receptor 2;transmission process;Up-Regulation;uptake;vector

PROJECT_TITLE: Regulation of hepatic hepcidin expression by transferrin receptor-2

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Chronic Pain;Genetics;Hematology;Human Genome;Neurosciences;Orphan Drug;Pain Research;Precision Medicine;Rare Diseases;Sickle Cell Disease

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Patients with sickle cell disease (SCD) experience acute pain events, or vaso-occlusive crises (VOC) which may progress to chronic pain. Our lack of understanding of the mechanisms and risk factors for progression to chronic pain, and lack of diagnostic biomarkers to identify VOC impairs our ability to appropriately treat VOC, and often results in potentiating and worsening chronic pain through excessive, inappropriate and ineffective exposure to opioids. Our innovative transcriptomics analysis of samples collected from relevant cell types from individuals with SCD with and without chronic pain, and paired genomics data, will address this unmet need.

PI_NAMEs: SHEEHAN, VIVIEN ANDREA (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Acceleration;acute care;Acute Pain;Address;Adhesions;Adult;Affect;American;ATAC-seq;Biological Markers;biomarker validation;Blood Cells;candidate identification;Caring;cell type;Cells;Childhood;Chronic;chronic pain;chronic pain management;chronic pain patient;clinical pain;clinically relevant;cohort;Collecting Cell;Collection;Confusion;Data;Development;diagnostic biomarker;differential expression;Drug Targeting;endogenous opioids;Endothelium;Erythrocytes;Erythroid;Erythroid Cells;Etiology;Event;Exhibits;experience;Exposure to;Frequencies;Genes;Genetic Transcription;genetic variant;Genome;genome sequencing;genomic data;genomic variation;Genomics;Germ-Line Mutation;Goals;Hemolytic Anemia;Hospitalization;Hospitals;Hyperalgesia;Impairment;improved;Individual;individual variation;Inherited;Injury;innovation;Ischemia;Leukocytes;Link;longitudinal analysis;metabolomics;methylomics;multiple omics;Nature;Nociception;novel therapeutics;Opioid;opioid overuse;Pain;Pain Measurement;Pain Nature;Pathway interactions;Patients;pediatric patients;Phenotype;precision medicine;Predisposition;prevent;Provider;PTPRC gene;Publishing;Quality of life;Recording of previous events;Resolution;Risk;Risk Factors;risk prediction;RNA;Sampling;Sickle Cell Anemia;sickling;single-cell RNA sequencing;Somatic Mutation;targeted treatment;Testing;TFRC gene;therapeutic target;transcriptome;transcriptome sequencing;transcriptomics;Variant;vaso-occlusive crisis;whole genome;Work

PROJECT_TITLE: Transcriptomics of Pain in Sickle Cell Disease

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: MAYWOOD

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: Project Narrative Relevance to Public Health: This research project is focused on an enzyme, SERCA, that transports calcium in all cells of the body. This pump is particularly important in the heart, where it controls the strength of the heart muscle contraction. Human heart failure is associated with disordered cardiac calcium handling, so SERCA is considered to be an important therapeutic target.

PI_NAMEs: ROBIA, SETH L (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Address;Adrenergic Agents;Affinity;Alberta province;ATP phosphohydrolase;Binding;Binding Sites;Biochemical;Biological Assay;Buffers;Calcium;candidate identification;Cardiac;cardiac pacing;Cells;Chemicals;Collaborations;Complex;Computer Simulation;computer studies;crosslink;Cryoelectron Microscopy;Cyclic AMP-Dependent Protein Kinases;Cytoplasm;Dependence;Disease;Docking;dwarf open reading frame;Enzymes;Epitopes;Exercise;experimental study;Fluorescence Resonance Energy Transfer;Frequencies;Functional disorder;Funding;Future;Goals;Grant;Health;Heart;Heart Diseases;Heart failure;Heart Rate;Human;In Vitro;in vitro Assay;insight;Kinetics;Laboratories;Mass Spectrum Analysis;Measurement;Membrane;Membrane Proteins;Methods;Microscopy;Microsomes;Modeling;Molecular;Molecular Conformation;molecular dynamics;multicatalytic endopeptidase complex;Muscle Contraction;Mutagenesis;Mutation;Myocardial Ischemia;Myocardium;novel;Pathogenicity;Pathologic;Peptide Fragments;Peptides;phospholamban;Phosphorylation;physiologic model;Physiological;Poison;Positioning Attribute;Predisposition;Productivity;Protein Fragment;Proteolysis;Proteome;Proteomics;Public Health;Pump;Recovery;Regulation;Research;Research Personnel;Research Project Grants;Research Support;response;Rest;Role;SERCA2a;Signal Transduction;simulation;Site;structural determinants;Structure;success;System;Testing;therapeutic target;Thermodynamics;Tissues;Universities;uptake

PROJECT_TITLE: Regulation of Cardiac Calcium Transport

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Trypanosoma brucei causes serious illnesses in humans and livestock that cause enormous suffering in Sub-Saharan Africa. We will study how the parasite establishes its shape, which is mediated by a specialized set of microtubules that underlie the cell surface. Our work will further the fundamental understanding of how T. brucei and other trypanosomatid parasites maintain and transmit the morphologies that are essential for their infectivity, which could open a new avenue towards therapeutics for treating a wide range of neglected tropical diseases.

PI_NAMEs: DE GRAFFENRIED, CHRISTOPHER LUIS (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Africa South of the Sahara;African Trypanosomiasis;Anterior;Binding;Binding Proteins;Biogenesis;Biology;biophysical techniques;Biotinylation;Blood;Cell division;Cell surface;Cells;Cellular Morphology;Complex;crosslink;Crowding;Cytokinesis;Cytoskeleton;daughter cell;Defect;Disease;Drug Design;Drug Targeting;Economic Burden;Environment;Eukaryota;Excision;Goals;Health;Human;human pathogen;Immunoprecipitation;In Vitro;Insecta;Kinesin;Leishmania;Length;live cell imaging;live cell microscopy;Livestock;Maintenance;Mammals;Maps;Mediating;Microtubule-Associated Proteins;Microtubules;Molecular;Morphology;Motor;nagana;Names;neglected tropical diseases;Organism;Orphan;Parasites;Pathway interactions;Phenotype;Physiologic pulse;Play;Plus End of the Microtubule;preference;Process;Production;Property;protein complex;Proteins;recruit;Research;RNA Interference;Role;scaffold;segregation;Shapes;Site;Sorting;stem;Structure;success;System;Testing;Therapeutic;Tissues;transmission process;Trypanosoma brucei brucei;Trypanosoma cruzi;ultra high resolution;Viscosity;Work;Yeasts

PROJECT_TITLE: Biogenesis of the Trypanosoma brucei subpellicular microtubule array

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Neuroblastoma;Neurosciences;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: OAKLAND

ORG_NAME: PUBLIC HEALTH INSTITUTE

PHR: Project Narrative The Children’s Oncology Group (COG) is the world’s largest organization devoted exclusively to childhood and adolescent cancer research with more than 9,000 members at over 220 leading children’s hospitals, universities, and cancer centers across the U.S., Canada and other countries. The COG conducts therapeutic trials as well as cancer control and cancer care delivery research studies to improve outcomes across diverse populations including adolescents and young adults with cancer.

PI_NAMEs: POLLOCK, BRAD H;ROTH, MICHAEL E. (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Acute;Acute Myelocytic Leukemia;Address;Adolescent;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adult;Aftercare;Age;anti-cancer research;base;Brain Stem Glioma;Canada;cancer care;Cancer Center;Cancer Control;cancer therapy;care delivery;Caring;Characteristics;Child;Childhood;childhood cancer survivor;Clinical Medicine;Clinical Research;Clinical Trials;Collaborations;Communities;Community Clinical Oncology Program;Community Participation;Complication;Country;data management;data quality;design;Disadvantaged;Disease;disparity elimination;Dose;effective therapy;Ensure;experience;follow-up;Functional disorder;Goals;Grant;Group Affiliation;health care delivery;health care service organization;Health Disparities Research;health disparity;health related quality of life;high risk;Hormonal;improved;improved outcome;Infant;Information Technology;Infrastructure;Institution;Interdisciplinary Study;Intervention;Laboratory Research;Late Effects;Leadership;long-term sequelae;Malignant Childhood Neoplasm;Malignant Neoplasms;member;Minority;minority disparity;Mission;Monitor;Morbidity - disease rate;mortality;Neuroblastoma;novel;optimal treatments;Organ;Outcome;outcome disparities;Pathology;Patients;Pediatric Hospitals;Pediatric Oncology;Pediatric Oncology Group;Persons;Population Heterogeneity;Positioning Attribute;prevent;Prevention;Prevention strategy;Prognosis;programs;Radiation Oncology;reproductive;Research;Research Personnel;research study;Resources;Second Primary Cancers;side effect;Site;Surgical Oncology;Survival Rate;survivorship;Symptoms;System;Therapeutic;Therapeutic Trials;Tissues;Translating;Treatment-related toxicity;underserved community;Underserved Population;Universities;Work;young adult

PROJECT_TITLE: Children's Oncology Group NCI Community Oncology Research Program (NCORP) Research Base grant


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Hematology;Rare Diseases;Sickle Cell Disease

ORG_CITY: DAR ES SALAAM

ORG_COUNTRY: TANZANIA U REP

ORG_FIPS: TZ

ORG_NAME: MUHIMBILI UNIVERSITY/ ALLIED HLTH SCIS

PHR: Project Narrative The Sickle Pan-African Research Consortium Clinical Coordinating Centre (SPARCO Center) together with six Consortium sites and the Sickle Africa Data Coordinating Centre will form the SCD in Sub-Saharan Africa (SSA) Network (SickleInAfrica). The specific aims of SPARCO Center will be to i) provide governance, oversight and operations, ii) expand the sickle cell registry and database to a total of 34,000 participants, iii) integrate SCD standards of Care into healthcare, iv) coordinate cohort and implementation research studies v) facilitate participation in short, medium and long-term skills development programs, and vi) facilitate engagement with public and private partners across the globe. The overall goal for SPARCO Center is to develop sustainable continent-wide SCD resources for multidisciplinary research that will increase understanding of SCD and improve health outcomes in Africa.

PI_NAMEs: MAKANI, JULIE  (contact)

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: Achievement;Address;Africa;Africa South of the Sahara;African;Area;authority;Biological Specimen Banks;Birth;Caring;cell community;cell registry;Clinical;cohort;Cohort Studies;Collaborations;Communication;comparative;Comprehensive Health Care;Confidentiality of Patient Information;Country;curative treatments;Data;data access;Data Coordinating Center;Data Element;data harmonization;data management;data repository;Data Set;data sharing;Databases;Descriptive Epidemiology;Development;Disease;Disease Management;disease phenotype;disease registry;Education;effective intervention;Elements;Enrollment;Ensure;Epidemiology;evidence base;experience;follow-up;Genetic Counseling;Genomics;Ghana;global health;Goals;Government Agencies;Growth;Guidelines;Health;Health care facility;Healthcare;Hematology;hydroxyurea;implementation intervention;implementation research;improved;Individual;innovation;Institution;Interdisciplinary Study;International;Knowledge;Link;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Neonatal Screening;Nigeria;Ontology;operation;Outcome;Participant;Patients;Phase;Phenotype;Policies;Privatization;Procedures;Process;Program Development;programs;Protocols documentation;Public Health;Quality of life;Recommendation;Registries;Reporting;Research;Research Methodology;Research Personnel;Research Priority;Research Project Grants;research study;Resource Sharing;Resources;Secure;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;sickling;Site;skill acquisition;skills;standard of care;System;Tanzania;Therapeutic;Training and Education;Training Programs;working group

PROJECT_TITLE: Sickle Pan-African Research Consortium Clinical Coordinating Center (SPARCO Center)


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health;Women's Health Research

ORG_CITY: WORCESTER

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Depression and poverty are linked together in an intractable syndemic affectig millions of people around the world. Poverty is a major cause of depression, while depression significantly reduces economic productivity. Integrated intervention approaches that seek to interrupt the cycle of poverty and depression have not been tested. This application describes ASHA: an integrated intervention that combines depression treatment with economic strengthening for depressed, low income women in rural Bangladesh. If the research is successful, we will work with government and NGO partners to initiate new collaborations between mental health researcher’s/policy makers and development groups seeking to increase economic productivity and wellbeing in Bangladesh and other countries of the global south.

PI_NAMEs: KARASZ, ALISON  (contact);TOFAIL, FAHMIDA

PROGRAM_OFFICER_NAME: CUBILLOS, LEONARDO

PROJECT_TERMS: Address;Advocate;Agriculture;arm;Asia;Bangladesh;career development;Caring;Child;Clinical;Cluster randomized trial;Collaborations;comparison control;contextual factors;cost;Country;Decision Making;Depressed mood;depressive symptoms;design;Development;diarrheal disease;disability;Disease remission;doctoral student;Dose;Economic Development;economic outcome;Economics;Effectiveness;empowerment;Evaluation;evidence base;experience;Family;Fellowship;fighting;Generations;Government;Government Agencies;graduate student;hands on research;Health;Health Care Costs;Health Personnel;High Prevalence;implementation outcomes;implementation process;implementation research;implementation study;improved;Individual;insight;International;international center;Interruption;Intervention;Intervention Studies;Interview;Investigation;Link;low and middle-income countries;Low income;Low Income Population;Manuals;Massachusetts;Mediating;Mediator;medical schools;men;Mental Depression;Mental Health;Methods;Modeling;novel;Outcome;pandemic disease;Participant;Pathway interactions;Patients;Perception;Personal Satisfaction;Persons;Pilot Projects;Play;Policies;Policy Developments;policy implication;Policy Maker;Poverty;poverty alleviation;process evaluation;Productivity;programs;psychosocial wellbeing;Randomized;recruit;Relapse;Research;Research Personnel;Research Training;Resource-limited setting;Role;Rural;Scientist;skills;Social support;Structure;syndemic;Testing;treatment arm;treatment effect;treatment trial;Universities;university student;uptake;Woman;Work

PROJECT_TITLE: ASHA Bangladesh--An Integrated Intervention to Address Depression in Low Income Rural Women


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cardiovascular;Clinical Research;Heart Disease;Orphan Drug;Pediatric;Pediatric Cancer;Physical Activity;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE Anthracycline anticancer agents are essential, lifesaving chemotherapies used in a majority of pediatric cancer patients but they confer a substantial long-term risk of heart failure, which is an important public health concern. This proposal seeks to define anthracycline-related cardiac remodeling, an important precursor to heart failure, through the development of new imaging-based markers and an examination of its relationship with modifiable risk factors and subsequent cardiac dysfunction. The goal of this research is to improve early detection and clinical prognostication, and to inform the future design of a targeted intervention to prevent heart failure in survivors of childhood cancer.

PI_NAMEs: NARAYAN, HARI KOPE (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: 3-Dimensional;Accelerometer;Adolescent and Young Adult;Anthracycline;Antibiotics;Antineoplastic Agents;Atrophic;Cancer Patient;Cardiac;cardiac magnetic resonance imaging;Cardiac Myocytes;cardiovascular disorder epidemiology;cardiovascular imaging;Cell Death;chemotherapy;Childhood;childhood cancer survivor;Clinical;Clinical Trials;clinically relevant;cohort;Computer Models;Data;design;Development;Diameter;Disease;Disease Marker;Dose;Early Diagnosis;effective intervention;exercise intervention;follow-up;functional decline;Functional disorder;Future;Goals;Heart failure;heart imaging;Hypertension;Hypertrophy;Image;Image Analysis;imaging biomarker;improved;improved outcome;Intervention;K-Series Research Career Programs;Leadership;Left;Left Ventricular Ejection Fraction;Left Ventricular Remodeling;Life;Long-Term Survivors;Longitudinal cohort;Machine Learning;Magnetic Resonance Imaging;Malignant Childhood Neoplasm;Mentorship;moderate-to-vigorous physical activity;modifiable risk;Myocardial;Myocardial dysfunction;Obesity;Oncology;patient oriented;patient oriented research;Patient Selection;Pattern;Physical activity;Physical assessment;Physicians;Physiological;Population;prevent;Process;prognostic;prognostication;Public Health;recruit;Research;Research Activity;Risk;Risk Assessment;Risk Factors;risk stratification;Scientist;Shapes;skills;success;Survivors;survivorship;targeted treatment;Thinness;Time;Training;treatment strategy;Variant;Ventricular;Work

PROJECT_TITLE: The Clinical Relevance of Anthracycline-Related Cardiac Remodeling in Childhood Cancer Survivors

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: HADLEY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: NARRATIVE The proposed research project will develop new statistical methods for analysis of Alzheimer’s disease (AD) studies that feature truncated or interval-censored covariates. Our methods will address analytic shortcomings that may have contributed to the conflicting findings regarding the potential efficacy of statins and the potential risk of proton pump inhibitors with respect to AD. The proposed statistical methodology that will eliminate the bias that may arise with truncated and interval-censored covariates, which are inherent to longitudinal cohort studies in AD and related dementias.

PI_NAMEs: QIAN, JING  (contact)

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: Acceleration;Address;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Amyloid;analytical method;Area;Autopsy;Blood Vessels;Calibration;Case Study;Cessation of life;Clinical;Cognitive;cohort;Cohort Studies;Complex;Computer software;cost;Cox Models;Data;Data Analyses;Data Set;Dementia;Development;discrete time;Disease Outcome;drug development;Drug Exposure;drug repurposing;Education;effective therapy;Evaluation;Event;Failure;Family history of;follow-up;Fostering;Functional disorder;Genotype;Impaired cognition;interest;Longitudinal cohort study;longitudinal dataset;Longitudinal Studies;Measurement;Methodology;Methods;Modeling;modifiable risk;neuropathology;Observational Study;Outcome;Parental Ages;Pharmaceutical Preparations;Probability;Process;Property;Proton Pump Inhibitors;Publishing;Regression Analysis;Reporting;Research;Research Project Grants;Risk;Risk Factors;Sampling;secondary analysis;sex;simulation;Source;Statistical Methods;Testing;Time;time use;Visit;Work

PROJECT_TITLE: Analysis of Alzheimer's disease studies that feature truncated or interval-censored covariates

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Nanotechnology;Pediatric;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: NEW ORLEANS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: NARRATIVE Current tuberculosis (TB) tests have reduced sensitivity when applied to diagnose young children who may develop more rapid and severe disease due to their immature immune systems, and this can delay or prevent the initiation of appropriate anti-TB treatment and result in more severe disease or death. Our initial proposal developed a blood-based biomarker assay that read by a mass spectrometer that sensitively detects proteins release by M, tuberculosis (Mtb) to diagnosis TB even in diagnostically challenging pediatric populations, and we now intend to expand upon this experience to develop a streamlined assay that is read by an inexpensive portable device that can be used in resource-limited settings where TB is often prevalent. This assay will detect proteins on extracellular vesicle (EV) secreted by Mtb-infected phagocytes and by immune cells to evaluate Mtb burden and its containment by the immune system, and thus provide critical information about pathogen-host interactions required improve pediatric TB diagnosis and to allow rapid assessment of the effectiveness of TB treatment.

PI_NAMEs: HU, TONY Y. (contact);LYON, CHRISTOPHER J;MITCHELL, CHARLES DEBEAUX

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: Adult;Aftercare;Antitubercular Agents;Award;Bacillus;Biological;Biological Assay;Biological Markers;biomarker signature;Blood specimen;blood-based biomarker;Body Fluids;Breakthrough device;Cells;Cessation of life;Characteristics;Child;Childhood;Chronic Disease;clinical application;cohort;Collaborations;Complex;Containment;Data;Detection;Development;Devices;Diagnosis;Diagnostic;Disease;DNA;Dominican Republic;Early Diagnosis;effectiveness evaluation;efficacy evaluation;Enrollment;Equipment;Evaluation;Exhibits;experience;extracellular vesicles;Guidelines;HIV;HIV Infections;Hospitals;Immune;Immune response;Immune system;Immune System Diseases;Immunoassay;improved;Individual;Infant;Integration Host Factors;International Maternal Pediatric Adolescent AIDS Clinical Trials;lifetime risk;Lung;machine learning algorithm;Macrophage;mass spectrometer;Mass Spectrum Analysis;Measurement;Methods;Modification;Monitor;Morbidity - disease rate;mortality;mycobacterial;Mycobacterium tuberculosis;nanoparticle;Outcome;pathogen;Pathogen detection;Pathogenesis;Pattern;Pediatric cohort;Performance;Phagocytes;Play;Population;portability;predictive modeling;preservation;prevent;Procedures;Process;prognostic performance;prospective;Prospective cohort;Proteins;Proteomics;Reporting;Reproducibility;Resource-limited setting;respiratory;Retrospective cohort;Risk;Role;Sampling;Serum;Signal Transduction;Sputum;Surface;Testing;Time;Translations;treatment response;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;Universities;Validation;validation studies;Variant

PROJECT_TITLE: Detecting pathogen and host factors on extracellular vesicles for pediatric TB diagnosis and management


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: HOUSTON

ORG_NAME: MARKER THERAPEUTICS, INC.

PHR: NARRATIVE This application will advance a novel therapy, whereby white blood cells are trained in the laboratory to recognize and kill cancer cells. These killer cells have the capacity to recognize multiple surface markers expressed by the tumor cells but not healthy cells. To date, more than 170 patients have been treated in clinical studies with this therapy with no serious side effects. This project will advance cell therapy in combination with existing chemotherapy to treat patients with acute myeloid leukemia (AML), a type of blood cancer with minimal treatment options and low survival rates, with the ultimate objective of getting marketing authorization to benefit more patients.

PI_NAMEs: ANGELO, LAURA S;VERA, JUAN FERNANDO (contact)

PROGRAM_OFFICER_NAME: WEBER, PATRICIA A

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adjuvant;Adverse event;Allogenic;Animal Model;Antigen Targeting;antigen-specific T cells;Antigens;arm;Authorization documentation;Azacitidine;Benefits and Risks;Biological Markers;Blood Component Removal;cancer cell;CAR T cell therapy;CD4 Positive T Lymphocytes;CD8B1 gene;cell killing;Cell Therapy;Cells;Characteristics;chemotherapy;Clinical;Clinical Research;Clonality;cohort;commercialization;cytokine;Data;Decitabine;design;Disease;Disease remission;Dose;effective therapy;efficacy evaluation;Environment;Epitope spreading;Evaluable Disease;Exhibits;experience;Future;Grant;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;human leukocyte antigen testing;Immune;Immune system;Immunologic Monitoring;improved;In Vitro;in vivo;in vivo monitoring;Infusion procedures;innovation;Intervention;Killer Cells;Laboratories;Leukocytes;Malignant Neoplasms;manufacture;Marketing;mortality;Multicenter Studies;neoplastic cell;neurotoxicity;novel;novel therapeutics;Orphan;Partial Remission;partial response;participant enrollment;Patient Monitoring;Patients;Phase;Phase II Clinical Trials;Phenotype;Population;post-transplant disease;pre-clinical;prevent;Protocols documentation;recruit;Regimen;Relapse;Research Design;Residual Neoplasm;response;Safety;safety assessment;Sampling;side effect;Signal Transduction;Specificity;standard of care;stem cell therapy;Stem cell transplant;Subgroup;Surface;Survival Rate;T cell therapy;T-Lymphocyte;targeted treatment;TCR Activation;Testing;Tissues;Training;tumor;Tumor Antigens;Tumor Escape;tumor growth;tumor specificity

PROJECT_TITLE: Phase 2 clinical trial of a novel T cell therapy following bridging therapy with hypomethylating agents for relapsed AML patients post-stem cell transplant


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pediatric;Pneumonia and Influenza;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PATHOLOGY

PHR: Narrative In mice, innate Type 3 cytokine producing lymphocytes (iT3L) expressing γδTCR (Tγδ17) are found preferentially in mucosal tissues of neonates and prevent eczema-like disease in the skin by fortifying the barrier. Lung Tγδ17 cells have similar function during neonatal flu infection. This proposal will determine whether the relative resistance to COVID-19 in infants is linked to heightened activities of neonatal Tγδ17 cells, and if so, how they can be mobilized in adults to confer improved resistance to SARS-CoV-2 infections.

PI_NAMEs: KANG, JOONSOO  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Adipose tissue;Adult;Age;age related;aged;Aging;Agonist;Birth;Bone Marrow;bone repair;Cell Count;cell type;Cells;Characteristics;Child;Cholesterol;Classification;COVID-19;COVID-19 pandemic;COVID-19 therapeutics;Cues;cytokine;Cytoprotection;Dangerousness;Data;Development;Diet;Diet Modification;dietary;directed attention;Disease;Eczema;Elderly;Embryo;embryonic stem cell;Epidemiology;Exhibits;fetal;Fortification;Funding;gain of function;Genes;Homeostasis;Human;IL17 gene;Immune;immune resistance;Immune response;Immunity;Immunomodulators;immunoregulation;improved;In Situ;Infant;Infant Health;Infection;Infiltration;Inflammatory;Inflammatory Response;Influenza;Influenza A virus;influenza infection;insight;interleukin-22;Kinetics;Knowledge;Link;Lung;Lung Diseases;Lung immune response;Lymphocyte;Lymphocyte Function;Lymphocyte Subset;Maintenance;Mediating;Methods;migration;Modeling;mouse model;Mucous Membrane;Mus;Neonatal;neonatal immune system;Neonatal lung;neonate;novel;novel therapeutics;pathogen;Population;post SARS-CoV-2 infection;prevent;Process;progenitor;Property;prototype;Reagent;reconstitution;Recording of previous events;Regulation;Resistance;resistance mechanism;respiratory;Respiratory Tract Infections;respiratory virus;response;SARS-CoV-2 immunity;SARS-CoV-2 infection;self-renewal;Sentinel;Sepsis;severe COVID-19;Skin;Source;Specific qualifier value;Structure of parenchyma of lung;T-Lymphocyte;Testing;Thymus Gland;tissue repair;Tissues;Virus;Virus Diseases;γδ T cells

PROJECT_TITLE: Identification of lung resident innate lymphocytes that specifically protect neonates from SARS-CoV-2 infections


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention

ORG_DEPT: DENTISTRY

PHR: Project Narrative According to the U.S. Centers for Disease Control and Prevention, 1 in 60 children have autism. The high rate of poor oral health in teens with autism and the considerable lifetime costs of preventable oral diseases underscore the importance of behavioral intervention research aimed at improving toothbrushing skills and habits. The proposed work is a critical first step in helping teens with autism develop long-term toothbrushing habits to prevent tooth decay, improve quality of life, and reduce well-documented disparities in oral health.

PI_NAMEs: CHI, DONALD LESLIE (contact)

PROGRAM_OFFICER_NAME: MATTIA, JILL

PROJECT_TERMS: Activities of Daily Living;Address;Adolescent;adolescent with autism spectrum disorder;Affect;Age;arm;Attention;autism spectrum disorder;autistic children;Behavior;behavior change;Behavior Therapy;Behavioral;Caregivers;Cartoons;Centers for Disease Control and Prevention (U.S.);Child;Childhood;Clinical;Computer software;Data;Dental Care;Dental caries;Dental Hygiene;Dental Offices;Dentistry;Dentists;design;Devices;digital;Discover, Design, Build, and Test Framework;Disparity;Educational process of instructing;effectiveness trial;efficacy trial;Engineering;Exhibits;experience;experimental arm;Face;Family;family burden;France;Frequencies;Friends;Funding;General Anesthesia;Goals;Grant;Habits;handheld mobile device;health inequalities;high risk;Home;improved;individuals with autism spectrum disorder;Industrialization;innovation;Intake;interest;Intervention;Intervention Studies;Interview;Learning;life time cost;Measures;Mediator;mobile application;Mobile Health Application;Modeling;Modification;Mouth Diseases;Neurologist;Occupational Therapist;Oral health;Outcome;Participant;Persons;Phase;pilot test;preadolescence;prevent;primary outcome;programs;Protocols documentation;prototype;Psychologist;Quality of life;Randomized;Recommendation;recruit;Research;Resistance;Risk;secondary outcome;Self Efficacy;Sensory;skills;sugar;Surveys;Technology;Teenagers;Testing;Time;Tooth structure;tooth surface;Toothbrushing;Training;treatment arm;Unhealthy Diet;United States National Institutes of Health;usability;Validity and Reliability;Visit;Work

PROJECT_TITLE: Testing a Mobile App to Improve Toothbrushing Skills and Habits in Teens with Autism.


NIH_SPENDING_CATS: Behavioral and Social Science;Dental, Oral, and Craniofacial Disease

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Project Narrative The proposed R25 summer program will provide ten deserving students per year the opportunity to experience multi-disciplinary, hands-on research in nationally recognized labs studying NHLBI mission- related projects. Their research experiences will also be complemented by career development activities that encourage a life-long commitment to scientific research in the next generation of health professional investigators. This R25 program will instill in our students a better appreciation of the important role for health professionals to have academic careers by motivating them to continue integrating research in their post-graduate clinical training in their chosen disciplines.

PI_NAMEs: FITZHUGH, MD, VALERIE A. (contact);FRAIDENRAICH, DIEGO

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Admission activity;Age;American Society of Hematology;Area;Association of American Medical Colleges;Biomedical Research;Biotechnology;Cardiovascular Diseases;Cardiovascular system;career;Career Choice;career development;Clinical;Clinical and Translational Science Awards;clinical training;Communication;Degree program;Dental;Dental Schools;design;disability;disadvantaged background;Discipline;Disease;Doctor of Philosophy;economic disparity;Education;Education Projects;education research;Educational Activities;Educational process of instructing;Eligibility Determination;Ensure;Ethnic Origin;Event;experience;Exposure to;Facebook;Faculty;faculty mentor;Fellowship;Funding;Future;Gender;General Population;graduate student;hands on research;Health;Health Occupations;Health Professional;Health Sciences;health training;Hematological Disease;Hematology;Infrastructure;interest;Journals;Knowledge;Laboratories;laboratory experience;Leadership;Learning;LinkedIn;Longterm Follow-up;Lung;Lung Diseases;Manuscripts;medical schools;Medical Students;Medicine;meetings;member;Mentors;Methodology;Minority;Mission;multidisciplinary;National Heart, Lung, and Blood Institute;New Jersey;next generation;Oral;Paper;Participant;Patients;peer;peer coaching;Persons;Pharmacologic Substance;Physicians;Postdoctoral Fellow;professional students;programs;prospective;Race;Reading;recruit;Research;Research Personnel;Research Project Grants;Residencies;responsible research conduct;Role;Schools;Science;Scientist;skills;social disparities;social media;Social Network;socioeconomic disadvantage;student participation;Students;summer program;summer research;Supervision;symposium;tool;Training;Training Programs;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;Wood material;Work;Writing

PROJECT_TITLE: Multidisciplinary Opportunities in Research Education for Students in Health Professions (MORESHP)


NIH_SPENDING_CATS: Back Pain;Bioengineering;Chronic Pain;Pain Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

ORG_CITY: NEW YORK

ORG_DEPT: ORTHOPEDICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Discogenic back pain, is a leading cause of disability, and involves degenerative changes of the intervertebral disc. Only a small subset of patients responds favorably to existing treatments, and there is a need for alternative options, including regenerative therapies. We are developing and optimizing use of anti-inflammatory cells for disc repair in hope that it improves outcomes for patients with back pain and degeneration.

PI_NAMEs: CHAHINE, NADEEN O. (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Address;Animal Model;Animals;Anti-Inflammatory Agents;Architecture;Area;Back Pain;Biochemistry;Biological;Biomechanics;bone marrow mesenchymal stem cell;Cell Transplantation;Cells;clinical efficacy;Clinical Research;Coculture Techniques;combat;Consensus;conventional therapy;Custom;cytokine;Data;disability;discogenic pain;Disease;Economic Burden;enhancing factor;Environment;Extracellular Matrix;Extracellular Matrix Degradation;Frequencies;Future;Goals;Height;Human;Hydrostatic Pressure;Immobilization;immunoregulation;improved;improved outcome;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;injured;Injury;innovation;Intervertebral disc structure;intervertebral disk degeneration;Label;Low Back Pain;Macrophage;mechanical load;Mediating;Mesenchymal Stem Cell Transplantation;Mesenchymal Stem Cells;Methods;migration;Modeling;Motion;Nitric Oxide;Operative Surgical Procedures;Opiate Addiction;Organ Culture Techniques;Outcome;pain behavior;Pain management;pain outcome;Paracrine Communication;patient subsets;Patient-Focused Outcomes;Physical therapy;Physiological;pre-clinical;Pre-Clinical Model;Production;Puncture procedure;Rattus;regenerative therapy;repaired;Research;response;Role;Severities;Signal Transduction;socioeconomics;Stem cell transplant;stem cells;Stimulus;Structural defect;Symptoms;System;Therapeutic;Tissues;TNF gene;Transforming Growth Factor beta;Transplantation;Treatment Efficacy;Up-Regulation

PROJECT_TITLE: Anti-inflammatory Cell Based Repair of Intervertebral Disc Degeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Recent discoveries of the phase-separation abilities of several chromatin regulators have led to novel models for chromatin organization. This project aims to develop biochemical, genetic and computational tools that enables studying the functional role of chromatin regulator phase-separation in individual living cells. We will apply these tools to the study of the regulation and impact of heterochromatin formation and transcription activation during stem cell differentiation.

PI_NAMEs: HUANG, BO  (contact);NARLIKAR, GEETA J;SHU, XIAOKUN

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Affect;Behavior;Biochemical;Biology;Bromodomains and extra-terminal domain inhibitor;Categories;cell fixing;Cell Line;Cells;cellular imaging;Chemicals;Chromatin;Chromatin Modeling;chromatin remodeling;Communities;computerized tools;Data;Data Set;Dependence;Development;Disparate;dosage;Enzymes;EZH2 gene;Fluorescence Microscopy;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Markers;Genetic Transcription;Genome;Goals;Heterochromatin;Histone Deacetylase Inhibitor;Human;Image;In Vitro;Individual;induced pluripotent stem cell;inhibitor;instrument;Introns;Link;Liquid substance;live cell imaging;live cell microscopy;Maps;Measurement;Measures;Modeling;multidisciplinary;Mutation;Nature;novel;Nuclear;Output;overexpression;Pathway interactions;Phase;Phenotype;Physical condensation;pluripotency;Process;programs;Property;Protein Dynamics;Protein Engineering;Protein Overexpression;protein protein interaction;Proteins;reconstitution;Regulation;RNA;Role;single cell genomics;single molecule;single-cell RNA sequencing;stem cell differentiation;synergism;System;technology platform;Testing;tool;Transcription Coactivator;Transcriptional Activation;transcriptome;transcriptome sequencing

PROJECT_TITLE: Modulation and functional characterization of protein condensation in chromatin organization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(70)R]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Aligned with NIH’s strategic priority to support innovations in HIV prevention, testing, adherence and retention to optimize HIV care continuum outcomes, the overall goal of the proposed study is to examine the impact and cost-effectiveness of an innovative multilevel intervention on HIV treatment adherence and engagement in care outcomes among school-going adolescents living with HIV (ALHIV) in Uganda. This R01 will combine group-based HIV stigma reduction for educators and Multiple Family Groups for HIV stigma reduction with a family economic empowerment intervention to address stigma and economic barriers associated with treatment outcomes and engagement in care. Findings may inform combination intervention efforts to optimize HIV treatment outcomes among ALHIV in Uganda and other countries in SSA.

PI_NAMEs: MUTUMBA, MASSY ;SSEWAMALA, FRED M (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Address;Adherence;Adolescent;Affect;Africa South of the Sahara;AIDS prevention;antiretroviral therapy;Appointment;arm;Attention;Attitude;care outcomes;Caring;Child;Cluster randomized trial;Commuting;Continuity of Patient Care;Cost Analysis;cost effectiveness;Country;Coupled;Development;Disadvantaged;Disclosure;Discrimination;Drowsiness;Economics;Education;empowerment;Enrollment;Exclusion;experience;Family;Family Relationship;family support;Feeling suicidal;Floor;Food;food insecurity;Fright;Gastric Emptying;Goals;HIV;HIV Infections;HIV-infected adolescents;HIV/AIDS;Home;improved;Inequality;Infection;innovation;Institution;Institutionalization;internalized stigma;Intervention;Intervention Studies;Literature;Living Arrangement;Mediation;medication compliance;Mental Depression;Mental Health;Nausea;Outcome;Parents;Participant;peer;Personal Satisfaction;Pharmaceutical Preparations;Pharmacy facility;pill;Policies;post implementation;Poverty;Prevalence;primary outcome;Privacy;programs;Randomized;recruit;Reporting;Research;response;Schedule;School Drop-Outs;school environment;Schools;secondary analysis;secondary outcome;Secondary Schools;Shame;side effect;Social Environment;social stigma;Structure;Student Dropouts;Students;Systems Theory;Testing;theories;therapy adherence;Thinking;Time;Training;treatment adherence;treatment as usual;Treatment outcome;treatment services;Uganda;United States National Institutes of Health;Violence;Viral

PROJECT_TITLE: M-Suubi: A Multi-level integrated intervention to reduce the impact of HIV stigma on HIV treatment outcomes among adolescents living with HIV in Uganda


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Estrogen;Neurosciences;Substance Misuse;Women's Health Research

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Substance use disorder (SUD) is a debilitating condition that is associated with poor decision making and elevated risk taking. Despite significant progress in identifying the behavioral and neurobiological mechanisms underlying this causal relationship, our understanding is still limited as the majority of the work has used male subjects. The objective of this proposal, which is the first step toward rectifying this limitation, is to investigate the neurobiological mechanisms by which estradiol promotes risk aversion in females; this knowledge will provide critical insight into how such mechanisms may be compromised after chronic substance use in females, resulting in elevated risk taking.

PI_NAMEs: TRUCKENBROD, LEAH MARIE (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: Abstinence;Amygdaloid structure;Behavior;Behavioral Mechanisms;career;Chronic;Circulation;Clinical;Data;Decision Making;Development;Dopamine;Dopamine D2 Receptor;Drug usage;ESR1 gene;Estradiol;Estrogen Receptor 2;Estrogen Receptors;Exhibits;experience;experimental study;Female;Foundations;Goals;Hormonal;Hormones;Impairment;Individual;insight;knock-down;Knowledge;Laboratories;Lead;male;Mediating;Modeling;neural;neurobiological mechanism;Neurobiology;neuromechanism;Neurons;Nucleus Accumbens;optogenetics;Ovariectomy;Pharmaceutical Preparations;Physiological;Positioning Attribute;preclinical study;Predisposition;Process;Proestrus;Punishment;Rattus;receptor function;Receptor Gene;receptor sensitivity;Regulation;Relapse;remediation;Research;Rewards;Risk;Risk Taking;RNA Interference;Rodent Model;Role;Scientific Advances and Accomplishments;selective expression;sex;Sex Differences;small hairpin RNA;substance use;Substance Use Disorder;Testing;Translating;Work

PROJECT_TITLE: Neurobiology of risk taking in females: hormonal modulation of basolateral amygdala function