NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Disease;Nutrition;Obesity

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Obesity and related metabolic disorders, including insulin resistance, type 2 diabetes, and non-alcoholic fatty liver disease, are an ever increasing worldwide problem leading to severe medical complications with substantial morbidity and mortality. It is well recognized that immune cells, such as macrophages, accumulate in obese fat tissue and liver and these cells have traditionally been implicated in promoting metabolic disease. We have found that macrophages also have a potentially important beneficial effect in these tissues, due to their ability to ingest and degrade excess lipids in adipose tissue and liver. Therefore, we hypothesize that genetically reprogramming macrophages to augment their lipid degradation machinery is a strategy to prevent and/or treat certain obesity- associated metabolic diseases. We propose to dissect the links between the macrophage lipid degradation machinery both in vitro and in vivo with the goal of developing a novel strategy for the treatment of obesity- associated insulin resistance and fatty liver disease.

PI_NAMEs: MITTENDORFER, BETTINA ;RAZANI, BABAK ;SCHILLING, JOEL DAVID (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acid Lipase;Adipocytes;Adipose tissue;Apoptotic;Atherosclerosis;Attenuated;Biogenesis;Buffers;Catabolism;Cells;Circulation;Complex;Cre driver;Crowns;cytokine;Data;Development;Diet;diet-induced obesity;Disease;exosome;Failure;Fatty acid glycerol esters;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Fatty Liver;fatty liver disease;Fibrosis;Functional disorder;Gene Cluster;gene network;Genes;Genetic Models;Genetic Transcription;glucose tolerance;Goals;Hepatocyte;High Fat Diet;Human;Hydrolysis;Immune;immune activation;improved;In Vitro;in vivo;Inflammation;Inflammatory;Ingestion;insight;Insulin Resistance;Interleukin-1 beta;Knockout Mice;Kupffer Cells;Link;lipid metabolism;lipid transport;Lipids;Lipolysis;Literature;Liver;Liver Fibrosis;lysosomal proteins;Lysosomes;Macrophage;Mediating;medical complication;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;Metabolism;Mitochondria;Modeling;monocyte;Morbidity - disease rate;mortality;Mus;Nature;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Obese Mice;obese person;Obesity;Obesity associated disease;obesity treatment;overexpression;oxidation;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Phagocytes;Phenotype;Plasma;Play;Population;prevent;programs;Proteins;Publications;Publishing;recruit;response;Role;Signal Transduction;Steatohepatitis;Structure;System;Testing;Tissues;TNF gene;transcription factor;transcriptome sequencing;TREM2 gene;Triglycerides;Up-Regulation;Work

PROJECT_TITLE: Harnessing macrophage lysosomal lipid metabolism in obesity-associated diseases

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Mental Health;Neurosciences;Prevention;Women's Health Research

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SURGERY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE The public health impact of cancer-related cognitive impairment (CRCI) is substantial; up to 80% of breast cancer patients exhibit CRCI during chemotherapy which can be debilitating. Some patients (survivors) of breast cancer also experience persistent long-term CRCI but long-term CRCI trajectories have been understudied. This proposal will add to the field by characterizing long-term CRCI with novel cognitive neuroscience-based measures and incorporating pre-chemotherapy and post-chemotherapy time-points. Lastly, we will assess the impact of CRCI on function and the role of inflammation in long-term CRCI by leveraging a large, nationwide, prospective study conducted in NCI-funded community oncology network.

PI_NAMEs: JANELSINS, MICHELLE C (contact)

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Age;Awareness;Biological Process;Breast Cancer Patient;cancer-related cognitive impairment;CCL2 gene;CCR5 gene;chemobrain;chemotherapy;Clinic;Clinical;clinically significant;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive neuroscience;cohort;Community Clinical Oncology Program;comparison control;Cyclophosphamide;daily functioning;Data;Delayed Memory;detection sensitivity;Evaluable Disease;Exhibits;experience;follow-up;frontal lobe;frontal lobe function;Functional disorder;Funding;Future;Gender;Hippocampus;Immune;Impaired cognition;Inflammation;Inflammatory;innovation;instrumental activity of daily living;intercellular cell adhesion molecule;Intervention Trial;Learning;Link;Literature;Long-Term Effects;Longitudinal Studies;Malignant Breast Neoplasm;Measurement;Measures;Mediating;Methods;Modeling;mouse model;Neuropsychological Tests;Neuropsychology;novel;Oncology;Paired-Associate Learning;Parietal Lobe;Pathway interactions;Patient Self-Report;Patients;Performance;Physical activity;pre-clinical;Prefrontal Cortex;Prospective Studies;Prospective, cohort study;psychologic;Public Health;Receptors, Tumor Necrosis Factor, Type II;Reporting;Research Design;Rodent;Role;Sampling;screening;Short-Term Memory;side effect;Survivors;sustained attention;Testing;Time;TNF gene;TNFRSF1A gene;TNFRSF1B gene;translational neuroscience;Vision;Visual;visual processing

PROJECT_TITLE: Translational Neuroscience Approaches to Cancer-Related Cognitive Impairment: Measurement, Mechanisms, and Function


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;HIV/AIDS;Health Services;Infectious Diseases;Lung;Patient Safety;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE HIV infection is a risk factor for chronic obstructive pulmonary disease (COPD) and COPD exacerbations, but risk factors for and outcomes following COPD exacerbations as well as the prescribing patterns and effect of guideline-concordant COPD care in people with HIV (PWH) are unknown. We therefore propose to perform a cohort study of HIV-infected and uninfected comparators with COPD using administrative and electronic health record data from multiple health systems across the US and a causal inference framework to identify modifiable risk factors for COPD exacerbations and poor outcomes and to investigate the links between processes of care and outcomes in PWH. Ultimately, this research will inform efforts to develop effective management strategies for high-quality COPD care in people with HIV.

PI_NAMEs: KONSTANTINIDIS, IOANNIS  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acceleration;Accounting;Acute;Adherence;Adult;Adverse effects;Affect;Age;Ambulatory Care;career development;Caring;case control;causal model;Cause of Death;CD4 Lymphocyte Count;Characteristics;Chronic;Chronic Care;Chronic Obstructive Pulmonary Disease;Clinical Data;Clinical Practice Guideline;Cohort Studies;Communication;comorbidity;comparative effectiveness;Continuity of Patient Care;cost;Critical Care;Data;Data Analyses;data integration;Data Mart;Data Science;Data Set;demographics;Development Plans;Disease Outcome;Disease Progression;Effectiveness;Electronic Health Record;Environment;Epidemiology;Event;Evidence based practice;experience;Female;Foundations;Future;General Population;Goals;Guideline Adherence;Guidelines;health data;Health Insurance;Health Services;Health system;HIV;HIV Infections;hospital readmission;Hospitalization;Hypersensitivity;immunodeficiency;improved;improved outcome;Incidence;Individual;Influenza vaccination;innovation;inpatient service;Institution;International;Intervention;Knowledge;Leadership;Linear Models;Link;Logistic Regressions;low socioeconomic status;Lung;Medicine;member;Mentors;Mentorship;Methodology;Minority;Modeling;modifiable risk;Morbidity - disease rate;mortality;Outcome;Patient Compliance;Patient-Focused Outcomes;Patients;Pattern;Persons;Pharmacotherapy;Population;Positioning Attribute;Practice Guidelines;Predisposition;Prevention Guidelines;Probability;Process;process improvement;Provider;Public Health;Public Health Informatics;pulmonary rehabilitation;Quality of Care;Quality of life;Random Allocation;Recommendation;Research;Research Activity;Research Personnel;Resources;Retrospective cohort study;Risk;Risk Factors;Sample Size;Sampling;Severities;sex;Site;skills;Smoking;smoking cessation;Socioeconomic Status;Spirometry;Statistical Models;Symptoms;System;Testing;Training;Training Activity;Universities;Viral Load result;Viremia;Work

PROJECT_TITLE: Risk factors for chronic obstructive pulmonary disease exacerbations, quality of care, and outcomes in people with HIV


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE The present proposal will test the effect of a novel intervention based on memory reconsolidation blockade on the participants’ physiological reactivity during script-driven imagery of the traumatic event. The project will test two interventions, mismatch vs. standard memory reactivation, under the influence of propranolol (a pharmacological agent that blocks memory reconsolidation). The project will serve as a proof of concept study for later, clinical propranolol mismatch stud(ies).

PI_NAMEs: ORR, SCOTT P.;TANEV, KALOYAN STEFANOV (contact)

PROGRAM_OFFICER_NAME: TUMA, FARRIS KEITH

PROJECT_TERMS: Adrenergic beta-Antagonists;Aftercare;American;Animal Experimentation;Animals;Basic Science;Behavior;Biological;Biology;brain tissue;Clinical;clinical application;Clinical Trials;cognitive task;design;Double-Blind Method;Elements;experience;experimental study;Exploratory/Developmental Grant;Face;falls;fear memory;Functional disorder;Galvanic Skin Response;Goals;Heart Rate;Human;Imagery;improved;innovation;insight;Intervention;Investigational Therapies;Journals;Laboratories;Measures;Memory;memory consolidation;Mental disorders;Mental Health;mental imagery;Molecular;National Institute of Mental Health;neural circuit;neuroimaging;novel;Outcome;Parents;Participant;permissiveness;Pharmaceutical Preparations;pharmacologic;PhenX Toolkit;Physiological;Placebo Control;Placebos;post intervention;Post-Traumatic Stress Disorders;post-traumatic symptoms;Predisposition;Process;Property;Propranolol;Psychiatry;psychologic;Psychophysiology;Publishing;Randomized;randomized placebo-controlled clinical trial;Reading;Reporting;Research;response;Science;Specific qualifier value;Symptoms;Testing;Time;traumatic event;treatment arm;United States National Institutes of Health;Work

PROJECT_TITLE: Mismatch vs. standard intervention during memory reconsolidation blockade with propranolol: effect on psychophysiological reactivity during traumatic imagery

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Genetics;Human Genome;Microbiome

ORG_CITY: HOUSTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: The ocular surface was initially thought to be sterile due to difficulty in obtaining viable microbes using traditional culture-based techniques, not to mention the potent anti-microbial defenses present in tears. Recent work has indicated the ocular surface is not sterile but contains a low biomass microbial community, which suggests these microbes may play a role in ocular health. In response to this U24 RFA, we propose to better define the breadth of microbes and microbial communities that populate the ocular surface through a combination of targeted cultivation and metagenomic sequencing approaches.

PI_NAMEs: BRITTON, ROBERT A;BROWN, ERIC L;DE PAIVA, CINTIA S. (contact);HOFFMAN, KRISTI LOUISE;PFLUGFELDER, STEPHEN C

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: antimicrobial;Archaea;Automobile Driving;Bacteria;Biological Assay;Biology;Biomass;Carbon;Cell Culture Techniques;Cell Physiology;Cells;commensal bacteria;Communities;conjunctiva;corneal epithelium;Coupled;Development;Diet;Ecology;Environment;Eye;Fractionation;fungus;Genes;Genome;Goals;Growth;Health;Human;Human body;Human Microbiome;immune function;Immune response;Immune system;Immunology;Individual;Inflammation;Intestines;Investigation;Large Intestine;Length;metabolomics;metagenome;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial;microbial community;microbial products;microbiome;microbiome composition;microbiome research;Monitor;multidisciplinary;multiple omics;novel;ocular microbiome;ocular surface;Oral cavity;Peripheral Blood Mononuclear Cell;Persons;Physiology;Pilot Projects;Resources;response;Ribosomal DNA;Sampling;Shapes;Shotguns;Site;Skin;Source;Sterility;Techniques;tool;United States National Institutes of Health;whole genome;Whole-Genome Shotgun Sequencing;Work

PROJECT_TITLE: Multi-method investigation and characterization of the ocular microbiome


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Although there is increasing evidence that financial incentives can improve the health of people living with HIV infection (PLHIV), it is unknown whether these benefits extend to PLHIV who have disengaged from HIV care. In this study, we will evaluate an incentive-based intervention for Tanzanian adults to support engagement in HIV care and adherence to antiretroviral treatment. Our findings will result in generalizable knowledge about the effectiveness of incentives for retention in HIV care and achievement of global targets to control HIV.

PI_NAMEs: SABASABA, AMON NKWABI;WANG, JINGSHEN  (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Address;Adherence;Adoption;Adult;Africa South of the Sahara;AIDS prevention;antiretroviral therapy;behavior change;behavioral economics;California;Caring;Child;Clinic;Collaborations;combat;Community Developments;comparison group;Consolidated Framework for Implementation Research;Continuity of Patient Care;Counseling;Country;Data;design;Development;Eastern Africa;Economics;Effectiveness;effectiveness evaluation;effectiveness measure;Effectiveness of Interventions;effectiveness/implementation study;Elderly;epidemic response;financial incentive;follow-up;Food;Gender;Goals;Government;Health;HIV;HIV Infections;Home;Home visitation;implementation intervention;implementation research;improved;incentive program;incentive strategies;incentive-based intervention;Incentives;Individual;Intervention;Interview;Investments;Knowledge;Longterm Follow-up;Machine Learning;markov model;Medical Records;Methods;mortality;motivated behavior;Motivation;NIH Office of AIDS Research;Outcome;outreach;Participant;Persons;Pilot Projects;Populations at Risk;Poverty;poverty reduction;Prevention;Prevention program;process evaluation;programs;Provider;Randomized;Recommendation;recruit;Reporting;Research;Research Priority;Risk;Safety;Services;Southern Africa;success;Surveys;Tanzania;Testing;theories;therapy adherence;Time;tool;treatment as prevention;treatment optimization;Universities;Viral;Viral Load result;Visit;Vulnerable Populations

PROJECT_TITLE: Strengthening the continuity of HIV care in Tanzania with economic support

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Microbiome

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Despite significant improvement in treatment using immune checkpoint inhibitors, non-small cell lung cancer remains the leading cause of cancer death, representing 22% of all cancer deaths. The gut microbiome has been identified as an independent, novel modulator of systemic anti-tumor responses to immunotherapy, but data remain limited by inconsistencies, lack of longitudinal analysis, and lack of functional characterization. The current proposal seeks to identify key metabolites and microbes or microbial communities that mechanistically impact systemic and intra-tumoral immune responses that either enhance or inhibit responses to immune checkpoint inhibitor therapy.

PI_NAMEs: SHAIKH, FYZA Y (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Adenosine Monophosphate;Affect;anti-PD-L1;anti-PD-L1 therapy;Antitumor Response;Bacteria;bacterial community;Biological Markers;biomarker identification;Cancer Etiology;Cancer Patient;cancer therapy;career development;CD8-Positive T-Lymphocytes;Cessation of life;Characteristics;checkpoint therapy;Classification;Clinical;clinical practice;Clinical Treatment;cohort;Colon;Communities;Cytotoxic T-Lymphocytes;Data;data integration;Deaminase;Dimensions;Disease;Disease Progression;Distant;DNA;Environment;Enzymes;Exhibits;fatty acid metabolism;fecal microbiota;Feces;Genes;genome sequencing;Germ-Free;Glucose;Goals;gut bacteria;gut microbes;gut microbiome;high dimensionality;Human;human microbiota;Immune;Immune checkpoint inhibitor;Immune response;Immunotherapy;improved;indexing;innovation;Inosine;Interferon Type II;Intervention Studies;Literature;longitudinal analysis;Longitudinal Studies;Malignant Neoplasms;Melanoma;metabolomics;Metagenomics;Microbe;microbial;microbial community;microbiome;microbiota metabolites;Modeling;mouse model;Mus;Mutation;Neoplasm Transplantation;Non-Small-Cell Lung Carcinoma;novel;Outcome;Pathway interactions;Patients;Physicians;Plasma;predictive marker;Production;Propionates;Publishing;Reporting;Resistance;responders and non-responders;response;Ribosomal RNA;Sampling;Scientist;single-cell RNA sequencing;Site;stool sample;study population;success;T cell receptor repertoire sequencing;T cell response;T-Lymphocyte;Testing;Therapeutic;Training;Translations;tumor;tumor microenvironment;Tumor-infiltrating immune cells;tumorigenic;Validation;Volatile Fatty Acids;whole genome

PROJECT_TITLE: Metabolite driven mechanisms by which gut microbes impact checkpoint inhibitor success in non-small cell lung cancer patients

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: The fellows and mentors trained by this program will contribute to short- and long-term improvements in global health. In collaboration with 21 low- and middle-income country institutions, fellows’ research will help develop clear and effective programs and policies to advance global public health, including care for HIV, other infectious diseases, noncommunicable diseases, global surgery, cancer, mental health and addiction, sexual and reproductive health, and planetary health.

PI_NAMEs: COHEN, CRAIG R (contact);LEE, SUNG-JAE ;MARTIN, NATASHA ;MARTÍNEZ-LÓPEZ, BEATRIZ

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: burden of illness;California;career;career development;Collaborations;Country;Dentistry;design;Discipline;Discipline of Nursing;Ensure;Environmental Science;Equity;Evaluation;experience;faculty mentor;Faculty Recruitment;Fellowship;Fostering;Funding;Future;global health;Goals;hands on research;Health;improved;Income;innovation;Institution;Instruction;Interdisciplinary Education;Leadership;Los Angeles;Medicine;Mentors;Mentorship;Modeling;online course;Personal Satisfaction;Postdoctoral Fellow;pre-doctoral;programs;Public Health;Race;recruit;Research;Research Methodology;Research Training;Resources;response;San Francisco;Site;Social Sciences;success;Training;Training and Education;Training Programs;Underrepresented Minority;Universities;veterinary science;Work

PROJECT_TITLE: University of California Launching Future Leaders in Global Health Research Training Program


NIH_SPENDING_CATS: Cancer;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE Dendritic cells are professional antigen-presenting cells and play a pivotal role in antitumor immunity and effective immunotherapy. We found that platinum-based chemotherapy reprograms lipid metabolism in small cell lung cancer, which reshapes the function of dendritic cells and leads to immune evasion. In this proposal, we will uncover the molecular mechanism by which platinum induces lipid reprograming and validate PPARa signaling as a therapeutic target to improve platinum/immunotherapy combination in small cell lung cancer.

PI_NAMEs: JIN, LINGTAO  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Acute;Allografting;antagonist;anti-PD-1;anti-PD-L1;anti-PD-L1 antibodies;anti-tumor immune response;Antigen Presentation;Antigen-Presenting Cells;arginase;Attenuated;Biological Assay;cancer immunotherapy;Cell Physiology;checkpoint therapy;chemotherapy;Chronic;Clinical;Combination immunotherapy;Combined Modality Therapy;Complex;Dendritic Cells;Development;efficacy evaluation;Enzymes;Exhibits;exosome;fatty acid metabolism;Fatty Acids;Functional disorder;Genetic;Genetically Engineered Mouse;Glutamine;Goals;humanized mouse;Immune;immune checkpoint blockers;Immune checkpoint inhibitor;Immune Evasion;immune function;Immune response;Immune System Diseases;immunogenicity;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Impairment;improved;in vivo Model;Infiltration;inhibitor;lipid metabolism;lipidomics;Lipids;long chain fatty acid;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mediator;Metabolic;Metabolism;metabolomics;Mitochondria;Modeling;Molecular;Mutation;Nature;neoplasm immunotherapy;patient subsets;PD-1/PD-L1;PD-L1 blockade;Peroxisome Proliferator-Activated Receptors;pharmacologic;Phenotype;Pilot Projects;Platinum;Play;pre-clinical;programs;Proteomics;Regulation;Respiration;response;Role;Shapes;Signal Transduction;small cell lung carcinoma;Survival Rate;T cell infiltration;Technology;Testing;Therapeutic;therapeutic target;TP53 gene;transcriptome sequencing;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor-Derived;tumor-immune system interactions;uptake;Validation;Work

PROJECT_TITLE: Platinum-induced lipid reprogramming and tumor immune microenvironment in SCLC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: Nashville

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Relevance Decreased sound tolerance (DST) is one of the most prevalent and persistent sensory features of autism spectrum disorder (ASD), currently affecting an estimated 2–3 million Americans with ASD and contributing to substantial distress and functional impairment. By providing a foundational understanding of both the psychological and physiological aspects of DST in ASD, this project is expected to improve the recognition, classification, and measurement of sound intolerance. In doing so, we will lay the foundation for future work aimed at developing targeted interventions for this debilitating symptom in persons on the autism spectrum.

PI_NAMEs: WILLIAMS, ZACHARY JAMES (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: acoustic reflex;Acoustics;Address;Adult;adult with autism spectrum disorder;Adverse reactions;Affect;American;Anxiety;associated symptom;Auditory;Auditory area;Auditory Perception;Auditory Physiology;auditory processing;Auditory system;autism spectrum disorder;autism symptoms;autistic children;avoidance behavior;Behavior;Behavioral;behavioral impairment;Brain Stem;Caregiver Burden;Caregivers;Characteristics;Child;Classification;Clinical;clinically significant;Communities;comorbidity;coping;Data;debilitating symptom;Development;Diagnostic;Dimensions;disabling symptom;Disease;Distress;effective intervention;Emotional;emotional reaction;Etiology;Event-Related Potentials;Evidence based treatment;Exhibits;experience;Family;Family member;Foundations;Frequencies;Fright;Functional disorder;Functional impairment;Future;General Population;Growth;Hyperacusis;improved;indexing;Individual;Individual Differences;individuals with autism spectrum disorder;insight;Intervention;Knowledge;Loudness;Loudness Perception;Mastication;Measures;meetings;Mental disorders;Meta-Analysis;middle ear;neural;neurophysiology;novel;otoacoustic emission;Pain;Participant;Patient Self-Report;Perception;Peripheral;Persons;phenomenological models;Phenotype;Physiological;Physiology;Population;Prevalence;Process;Psychoacoustics;psychologic;Psychometrics;Psychophysics;Psychophysiology;Pure-Tone Audiometry;Questionnaires;recruit;repetitive behavior;Reporting;Research;research clinical testing;Research Personnel;response;Safety;Sampling;Schools;Self Administration;Sensory;Sensory Manifestations;sensory stimulus;Severities;social;sound;Source;Stimulus;Subgroup;Surveys;symptom cluster;symptomatology;Symptoms;Syndrome;Testing;Tympanometry;Ultrasonography;United States;Variant;verbal;Work;Workplace

PROJECT_TITLE: Investigating the Phenomenology and Physiologic Underpinnings of Decreased Sound Tolerance in Adults with Autism Spectrum Disorder


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_DEPT: PATHOLOGY

PHR: Project Narrative Hepatoblastoma and hepatocellular carcinoma are the most frequently diagnosed liver tumors in children, and they represent a remarkable variety of biologies, histologies, and outcomes: low-risk HBs are cured with a combination of chemotherapy and surgical resection, while high-risk HBs and HCCs continue to have a dismal prognosis of 30-50% at 5 years despite of aggressive medical and surgical therapies. Treatments for these tumors include chemotherapy using cisplatin and other chemotherapeutic agents, as well as surgical resection and liver transplantation; these treatments are associated with risks that range from developmental impairments to death due to toxicity, transplant rejection, or secondary drug-resistant lesions. We propose to systematically validate assays and models that will help distinguish between tumor subtypes, evaluate risk, and help select optimal toxicity-to-outcome treatment tradeoffs for HB and HCC patients.

PI_NAMEs: LOPEZ-TERRADA, DOLORES  (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: 5 year old;6 year old;Adolescent;Affect;aggressive therapy;Biological Assay;Biological Markers;Biology;biomarker validation;Cardiotoxicity;Categories;Certification;Cessation of life;chemotherapeutic agent;chemotherapy;Child;Childhood;Cisplatin;Classification;CLIA certified;Clinical;Clinical Trials;cohort;Collaborations;Combination Drug Therapy;Combined Modality Therapy;Data;Development;Diagnosis;dosage;Drug resistance;Enrollment;Europe;European;Excision;Funding;Graft Rejection;Hepatic;Hepatoblastoma;High Dose Chemotherapy;high risk;Histology;Immunotherapy;Impairment;improved;improved outcome;International;Intervention;Intervention Studies;Investigational Therapies;Lesion;Liver;liver cancer patient;Liver neoplasms;liver transplantation;Malignant Neoplasms;Medical;Modeling;Molecular;Molecular Diagnosis;molecular marker;molecular modeling;Molecular Profiling;Morbidity - disease rate;Neoplasm Metastasis;Neoplasms;nephrotoxicity;neurotoxicity;Nonmetastatic;Operative Surgical Procedures;ototoxicity;Outcome;participant enrollment;Patient Recruitments;Patient-Focused Outcomes;Patients;Pediatric cohort;Pediatric Neoplasm;Pediatric Oncology Group;personalized medicine;Play;predictive marker;predictive modeling;predictive test;Preparation;Primary carcinoma of the liver cells;profiles in patients;Prognosis;Prognostic Marker;prospective;Quality of life;recruit;research clinical testing;Resected;Resistance;response;Risk;Risk Estimate;risk prediction;risk prediction model;risk stratification;Second Primary Cancers;Stratification;Survival Rate;targeted treatment;Testing;Therapeutic Trials;Toxic effect;transplantation therapy;treatment optimization;Treatment outcome;Treatment-related toxicity;tumor;Tumor Subtype;Unresectable;Validation;Work

PROJECT_TITLE: Validation of Clinical Assays for Risk Stratification of Children With Pediatric Liver Neoplasms


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Prevention;Schizophrenia;Serious Mental Illness

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: There is a high prevalence of loneliness among people with schizophrenia, yet little is presently known about the effects of loneliness on health and well-being in this at-risk population as they age. This information is critically important as loneliness is not just psychologically distressing, but is also associated with increased risk of worse health outcomes such as medical disorders, cognitive decline, reduced independence skills, worse overall well-being, and early mortality. This study will comprehensively examine the effects of loneliness and aging in schizophrenia in terms of such health outcomes in order to better guide comprehensive personalized care for older adults with schizophrenia.

PI_NAMEs: PALMER, BARTON W. (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Accounting;Activities of Daily Living;Acute;Address;Adult;Adverse effects;Affect;Age;age acceleration;Aging;Alcohol consumption;Awareness;Biological;Biological Markers;Cellular Phone;Cigarette;Cognition;Cognitive;cognitive function;comorbidity;Data;Data Analyses;data reduction;depressive symptoms;design;Development;Diabetes Mellitus;Diagnosis;Disease;Ecological momentary assessment;Elderly;Epidemic;Factor Analysis;follow-up;Gender;General Population;Health;Health behavior;health related quality of life;High Prevalence;human old age (65+);Impaired cognition;individualized medicine;individualized prevention;innovation;International;Life Cycle Stages;Loneliness;Measurement;Measures;Medical;Mental Depression;middle age;Moods;mortality;mortality risk;Nature;Obesity;older adult;Outcome;Pathology;Patient Care;Pattern;Personal Satisfaction;personalized care;Persons;Physical activity;physical conditioning;Physiological;poor health outcome;Populations at Risk;Prevalence;prevent;psychological distress;Psychopathology;Research;Rest;Risk;Risk Factors;Schizophrenia;Severities;skills;Smoking;social;Social isolation;Surgeon;Testing;theories;Time;time use;trait;Visit

PROJECT_TITLE: Loneliness in Aging with Schizophrenia


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Liver Disease;Nutrition;Obesity

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, and it occurs when overnutrition and obesity trigger fat accumulation and inflammation in the liver through mechanisms that are poorly understood. This research aims to investigate how inflammation perturbs the metabolic state of liver cells, and influences the development of NAFLD and its associated complications. These studies will help develop novel approaches for improving the metabolic health of patients with NAFLD.

PI_NAMEs: PATEL, SURAJ J (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Adipose tissue;Alleles;Binding;Body Weight;career;career development;Cell model;Cells;Ceramides;ChIP-seq;Chronic;chronic liver disease;Coculture Techniques;Complex;Data;Data Set;Dedications;Development;Endocrinology;Ensure;Environment;epigenomics;Fatty acid glycerol esters;Fatty Liver;FDA approved;Foundations;Functional disorder;gain of function;Gastroenterology;Genes;Genetic Transcription;genomic locus;Genomics;Glucose Clamp;Goals;Health;Hepatic;Hepatocyte;Hepatology;High Fat Diet;Hyperinsulinism;immune function;immunoregulation;improved;in vitro Model;Inflammation;Inflammatory;Inflammatory Response;Insulin Resistance;insulin sensitivity;insulin signaling;interest;Interferons;IRF3 gene;ISG15 gene;Joints;Kupffer Cells;Laboratories;Link;Liver;Liver diseases;loss of function;LoxP-flanked allele;Macrophage;Mediating;Metabolic;Metabolic Control;Metabolic dysfunction;Metabolism;Mus;Natural Immunity;non-alcoholic fatty liver disease;novel strategies;Obesity;Overnutrition;Pathway interactions;Patients;Phenocopy;Phosphorylation;Phosphotransferases;Physiological;Physiology;Play;programs;Protein Phosphatase 2A Regulatory Subunit PR53;Proto-Oncogene Proteins c-akt;Research;Research Personnel;Resources;Role;success;System;TBK1 gene;Techniques;Testing;Thermogenesis;Tracer;transcription factor;Transcriptional Regulation;transcriptome;Work

PROJECT_TITLE: Innate immune regulation of hepatic insulin sensitivity and metabolism

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: OMAHA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: Public Health Relevance Statement Soil-transmitted helminth parasites like roundworms, whipworms, and hookworms affect the health of over a billion people in developing countries and are most common in children between the ages of 3 and 8. Treatment includes using nicotinic anthelmintics like levamisole and pyrantel, which paralyze the nematodes by activating the cholinergic ion channels on their muscle. These parasites are complex organisms that recover from exposure to nicotinic anthelmintics through mechanisms that are not well understood. Our study will provide insight into the mechanisms of nicotinic anthelmintic recovery using a parasitic nematode model, Brugia malayi, and how macrocyclic lactones can prevent this recovery.

PI_NAMEs: KASHYAP, SUDHANVA SRINIVAS (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Abdominal Pain;Adopted;Adult;Adult women;Affect;Age;Agonist;Albendazole;Anthelmintics;Ascaris lumbricoides;benzimidazole;Biological Assay;Brugia malayi;Caenorhabditis elegans;Calcium;Child;cholinergic;Climate;Cognitive;Complex;desensitization;Developing Countries;Diarrhea;disease transmission;Down-Regulation;Drosophila acetylcholine receptor alpha-subunit;drug metabolism;Endoplasmic Reticulum;Excretory function;experimental study;Exposure to;Female;filaria;Growth;Health;helminth infection;Helminths;Hookworms;Hygiene;Image;Immobilization;improved;in vivo;in vivo calcium imaging;Individual;Infection;insight;Ion Channel;Ivermectin;Kinetics;knock-down;Lactones;Levamisole;male;Malnutrition;Measures;Mediating;Membrane;Modeling;Motility;moxidectin;Muscle;Mutation;Nematoda;Nematode infections;nicotine exposure;nicotine use;Nicotinic Agonists;novel;Old World Hookworm;Organism;Paralysed;Parasite Control;Parasites;Parasitic nematode;Persons;Pharmaceutical Preparations;Play;prevent;Prevention;Proteins;Public Health;public health relevance;Pyrantel;receptor;Recovery;Rectal Prolapse;Reporting;Resistance;Resistance development;RNA Interference;Role;Ryanodine;Ryanodine Receptor Calcium Release Channel;Sanitation;Sex Differences;Soil;synergism;Tachyphylaxis;Testing;Transcript;transcription factor;transmission process;Treatment Protocols;Trichocephalus trichiura

PROJECT_TITLE: Cholinergic anthelmintics: Tachyphylaxis mechanisms and control in a parasitic nematode model,Brugia malayi

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Brain Disorders;Human Fetal Tissue;Multiple Sclerosis;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: AMHERST

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: NARRATIVE We seek to design novel hydrogels to increase the viability and enhance the differentiation capacity of human oligodendrocytes upon transplantation to demyelinating brain. We will also develop novel animal models of brain demyelination that mimic human diseases such as multiple sclerosis and employ them to test cell therapies. The proposed work has enormous implications for regenerative medicine, as it has the potential to develop novel strategies to enhance stem cell delivery for treatment of devastating neurodegenerative diseases that remain intractable to current treatments.

PI_NAMEs: ANDREADIS, STELIOS THEOHARIS (contact);SIM, FRASER JAMES

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Acceleration;Address;Alloantigen;Animal Model;animal model development;Apoptosis;Area;Biocompatible Materials;Biological;Biomedical Engineering;Brain;Cell Death;Cell Fate Control;Cell Maintenance;cell preparation;cell replacement therapy;Cell Survival;Cell Therapy;Cell Transplantation;Cells;Central Nervous System;chronic demyelination;Clinical Treatment;Corpus Callosum;Cues;Data;Demyelinating Diseases;Demyelinations;design;Development;Disease;Environment;Formulation;Goals;Grant;Growth Factor;Human;human disease;hydrogel scaffold;Hydrogels;Immunosuppression;implantation;improved;improved outcome;in vivo;Inflammation;Injections;injured;Injury;innovation;Ischemia;Isoantibodies;Laboratories;Maintenance;mechanical properties;Mediating;Methods;minimally invasive;Modeling;Multiple Sclerosis;Mus;Myelin;myelination;nerve stem cell;Nervous System Physiology;Neurodegenerative Disorders;Neuroglia;Neurosciences;novel;novel strategies;Oligodendroglia;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;Peptides;Preparation;prevent;Proliferating;Regenerative Medicine;regenerative therapy;remyelination;repaired;Rodent;Series;shear stress;Site;Spinal Cord Diseases;Spinal cord injury;stem cell delivery;stem cell fate;stem cell survival;Stem cell transplant;Testing;Thinness;Tissues;translational approach;Translations;Transplantation;Work

PROJECT_TITLE: Programmable Hydrogels for Optimized Human Oligodendrocyte Transplantation in Demyelinating Disease

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative Patients with Alzheimer’s disease have plaques in their brains containing, among other things, caspase cleaved tau protein. The goal of this proposal is to characterize the role that caspase cleavage of tau plays in the progression of tau pathology. The outcome of these experiments will provide valuable insight into events happening early in the progression of Alzheimer’s disease as well as further validate caspases as targets for the development of treatments for the disease.

PI_NAMEs: AMBROSE, ANDREW J (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Ablation;Adverse effects;Affect;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;American;Amyloid beta-Protein;amyloid peptide;Animal Model;Apoptosis;Arachidonic Acids;Aspartate;Behavior;Biological Assay;Brain;CASP3 gene;CASP6 gene;Caspase;Cause of Death;Cell Death;Cell Death Induction;Cell Line;Cell model;Cells;Cessation of life;Characteristics;Chemicals;cost;Cycloheximide;design;Development;Digestion;Disease;Disease Progression;Engineering;Enzymes;Event;experimental study;Family;Genetic;Goals;gray matter;Growth;Half-Life;Health;Health Care Costs;In Vitro;in vivo;Induced pluripotent stem cell derived neurons;Inflammation;inhibitor;insight;Kinetics;Knock-out;Knockout Mice;Knowledge;Lead;Length;Lewy Body Dementia;liquid chromatography mass spectrometry;Measures;Mus;Mutation;Nerve Degeneration;neuroblastoma cell;neuroinflammation;neuron loss;Neurons;Outcome;overexpression;Pathology;Peptide Hydrolases;Persons;Pharmacologic Substance;Phenotype;Play;Positioning Attribute;Post-Translational Modification Site;Predisposition;Protein Isoforms;Proteins;proteotoxicity;Recombinant Proteins;Recombinants;Research;Resistance;response;Role;Senile Plaques;Series;Site;Specificity;Staurosporine;Stress;System;tau aggregation;tau mutation;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic Intervention;therapeutic target;therapy development;Toxic effect;Trypsin;United States;Up-Regulation;Vesnarinone;Western Blotting

PROJECT_TITLE: Deteriming the Role of Caspase Cleaved Tau in Alzheimer’s Disease


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Nanotechnology;Regenerative Medicine

ORG_DEPT: DENTISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: This translational study presents a novel epigenetic approach for attenuating periodontitis, the leading cause of tooth loss, in which two epigenetic modulators, with distinct and complementary effects, will be carried and delivered to the targeting cells in the diseased sites by nanoparticles newly developed at the Massachusetts Institute of Technology (MIT). A synthetic BET inhibitor specifically targets inflammatory and bone-resorbing cells to halt the progression of the disease, and a particular noncoding RNA deploys the endogenous capacity to restore the normal structure contours and functions of the tissues damaged in periodontitis. This approach represents a paradigm shift in developing a strategy, because it efficiently challenges the major etiology of periodontitis and regenerates a healthy periodontium, saving the teeth of millions of patients.

PI_NAMEs: CHEN, JAKE JINKUN (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: 3' Untranslated Regions;Adult;Affinity;Age;alveolar bone;Alveolar Bone Loss;American;Area;beta catenin;Binding;Biocompatible Materials;Biological;Biology;bone;Bone Marrow;bone mass;Bone Regeneration;Bone Resorption;Bromodomain;Bromodomains and extra-terminal domain inhibitor;Cell Differentiation process;Cell Physiology;Cell Proliferation;cell type;Cells;Cellular biology;Clinic;Clinical Trials;Crossbreeding;cytokine;cytotoxicity;design;Disease;Disease Progression;Dose;Drug Delivery Systems;Drug Kinetics;Endogenous Factors;Epigenetic Process;epigenetic therapy;Etiology;experience;Experimental Pathology;familial amyotrophic lateral sclerosis;Foundations;Functional disorder;Gene Deletion;Gene Expression;gene therapy;Genes;genetic element;genetic manipulation;Genetic Transcription;Goals;healing;human disease;Immune Complex Diseases;Immunology;Individual;induced pluripotent stem cell;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injections;innovation;invention;Investigation;Knockout Mice;Knowledge;Laboratories;Macrophage;Massachusetts;Measurement;Mediating;MicroRNAs;Modeling;Modification;Molecular;Molecular Biology;mouse model;Mus;nano;nanomaterials;nanoparticle;Natural regeneration;novel;novel therapeutics;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteogenesis;Outcome Measure;overexpression;Palliative Care;Pathogenesis;Pathologic;Pathway interactions;Patients;Periodontal Diseases;Periodontitis;Periodontium;Pharmacodynamics;Phenotype;Population;Protein Inhibition;regenerative;Regulator Genes;Reporting;Resistance;Ribosomal DNA;Rodent;Role;Severity of illness;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;skills;Stromal Cells;Structure;System;Technology;Tertiary Protein Structure;Therapeutic;Therapeutic Agents;therapeutic gene;Time;tissue regeneration;Tissues;Tooth Loss;Tooth structure;transcription factor;transcriptomics;Transgenic Mice;translational study;Treatment Efficacy;Untranslated RNA

PROJECT_TITLE: Potentials of Epigenetic Molecules in Attenuating the Phenotypes of Periodontitis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: CORVALLIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: Public Health Relevance Schistosomes are water-borne blood-flukes that are transmitted by snails, infecting over 250 million people in more than 70 countries, and causing severe and chronic disability. We will identify new genes that make some snails naturally resistant to infection by schistosomes. Identifying such genes will reveal potential new ways to reduce parasite transmission at the snail stage.

PI_NAMEs: BLOUIN, MICHAEL SCOTT (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Affect;Alleles;Binding;Biomphalaria;Candidate Disease Gene;Chronic disability;Chronic Disease;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Country;Data;DNA Sequence;Dose;Drug resistance;effective therapy;Etiology;Generations;Genes;Genetic;genetic manipulation;Genetic Polymorphism;Genetic Variation;Genome Scan;genome wide association study;Genomic Segment;Geography;Goals;Haplotypes;Helminths;Homozygote;human disease;Immune response;Immunology;Inbreeding;Individual;Infection;Interruption;Knock-out;Knowledge;Ligands;Link;Location;Maps;Methods;Modernization;Modification;Molecular;Names;Natural Resistance;novel strategies;Parasites;Parasitic Diseases;Pathway interactions;Persons;Pharmaceutical Preparations;Poison;Population;Predisposition;public health relevance;Quantitative Trait Loci;Research;Resistance;resistance gene;Resistance to infection;resistant strain;RNA Interference;Schistosoma;Schistosoma mansoni;Schistosoma mansonii infection;Schistosomatidae;Schistosomiasis;Side;snail protein;Snails;Susceptibility Gene;System;Testing;trait;transcriptome sequencing;transmission blocking;transmission process;Untranslated RNA;Vaccines;Variant;waterborne;Work

PROJECT_TITLE: Genetic mechanisms of snail/schistosome compatibility

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE A major challenge in treating Fontan heart/circulation failure is in understanding the unique mechanisms of failure in these patients, since standard heart failure therapies are ineffective in this population. We have previously shown that mitochondrial injury plays a major role in this form of heart failure, and here will evaluate how mitochondrial injury in cardiac muscle cells leads to impaired function in cardiac blood vessel cells by cell-to-cell transport of damaged mitochondria. Through better understanding of the unique mechanisms of single ventricle heart failure we are poised to develop new strategies for prevention and treatment focused on cellular energetics and vascular dysfunction.

PI_NAMEs: REDDY, SUSHMA  (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: 3-Dimensional;4 hydroxynonenal;Acute;Adrenergic beta-Antagonists;Affect;angiogenesis;Angiotensin-Converting Enzyme Inhibitors;Biogenesis;Biological Markers;Biology;biomarker identification;Blood Vessels;Cardiac;Cardiac Myocytes;Cardiovascular system;Cell Communication;Cell Death;Cell Physiology;Cells;Child;Chronic;circulating biomarkers;Circulation;Clinical;Coculture Techniques;cohort;Common Ventricle;Communication;comparison control;Complex;congenital heart abnormality;Data;Distant;effectiveness evaluation;Endothelial Cells;Endothelium;extracellular vesicles;Failure;FDA approved;Fibrosis;Fontan Procedure;Functional disorder;functional status;Generations;Goals;Growth Factor;Heart;Heart failure;heart function;heart preservation;human induced pluripotent stem cells;human tissue;Hypoxia;Impairment;ineffective therapies;inhibitor;Injury;innovation;Ischemia;ischemic cardiomyopathy;Kidney;lens;Lipid Peroxidation;Liver;Long-Term Survivors;Malondialdehyde;Measures;Mediating;Membrane;Metabolic;Microvascular Dysfunction;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modification;Monitor;Myocardial;Myocardial tissue;Myocardium;new therapeutic target;novel therapeutics;Operative Surgical Procedures;Organ;oxidation;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Patients;Peripheral;Phenotype;Phospholipids;Plasma;Play;Population;pressure;prevent;Prevention strategy;Prevention therapy;Proteomics;Reporting;Role;Severities;Severity of illness;Single ventricle congenital heart disease;small molecule;small molecule therapeutics;Spatial Distribution;Stress;targeted treatment;Techniques;Testing;therapeutic development;Tissue imaging;Tissues;Treatment Failure;Trees;Vascular Diseases;Vascular Endothelial Cell;vascular endothelial dysfunction;Ventricular Function

PROJECT_TITLE: Lipid Peroxidation-Induced Mitochondrial Injury Inhibits Vascular Function in Single Ventricle Congenital Heart Disease

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Antimicrobial Resistance;Immunotherapy;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PHR: Bacterial pneumonia is a major health burden worldwide, and new treatment approaches are urgently needed. Follistatin-like protein 1 (FSTL-1) is a novel host immunomodulator in the lung, though the role of FSTL-1 in lung host defense is unknown. This proposal aims to determine the molecular and cellular requirements of FSTL-1-mediated pulmonary host defense pathway, and outcomes of these studies will inform host-derived, immune targeting therapeutic approaches for the treatment of bacterial pneumonia.

PI_NAMEs: CAMPFIELD, BRIAN T (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Adult;Agonist;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Asthma;Autoimmunity;Bacterial Antibiotic Resistance;Bacterial Infections;Bacterial Pneumonia;bactericide;Binding;Biology;Bronchoalveolar Lavage Fluid;Cause of Death;CD14 Antigen;CD14 gene;Cells;Cessation of life;Child;Clinical;Complex;conditional knockout;cost;Critical Pathways;Data;Development;Disease;extracellular;Follistatin;Follistatin-Related Protein 1;Genes;Genetic Transcription;Health;Health Care Costs;Homeostasis;Hospitalization;Host Defense;Immune;immune function;Immune Targeting;Immunity;Immunomodulators;immunomodulatory therapies;Immunotherapy;Impairment;improved;In Vitro;in vivo;in vivo Model;Infection;Inflammatory;innovation;Klebsiella pneumoniae;Knockout Mice;Knowledge;Lead;Literature;Lung;lung development;Lung infections;Malignant Neoplasms;Mediating;Mediator;Modeling;Molecular;Morbidity - disease rate;mortality;mucoid;Mus;Natural Immunity;neutrophil;Neutrophil Infiltration;NF-kappa B;Nosocomial pneumonia;novel;novel strategies;novel therapeutic intervention;Nuclear Hormone Receptors;Outcome Study;pathogen;Pathogenesis;Pathway interactions;Phagocytosis;Pneumonia;pneumonia model;pneumonia treatment;Population;Pre-Clinical Model;Predisposition;Production;Public Health;Publications;Publishing;Pulmonary Emphysema;Pulmonary Fibrosis;receptor;Recombinants;Resistance to infection;Respiratory Burst;response;Role;Signal Transduction;Surface;System;targeted treatment;Testing;Therapeutic;therapeutic target;TLR4 gene;tool;Wild Type Mouse;Work

PROJECT_TITLE: Follistatin-like 1 Mediated Host Defense in Bacterial Pneumonia

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative Developing policies and practices that maximize later life-course health and well-being while minimizing disparities across population subgroups requires understanding the social determinants of physical, emotional, cognitive, and economic health. The Life Course Center (LCC) at the University of Minnesota provides the theoretical frameworks and outstanding research infrastructure—including access to innovative sources of population data—needed to address these crucial issues. The Center facilitates interdisciplinary collaborations to directly addresses Goal E of NIA’s Strategic Directions (2016): to “improve our understanding of the consequences of an aging society to inform intervention development and policy decisions”

PI_NAMEs: FLOOD, SARAH M (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: access restrictions;Address;Adult;Aging;Alzheimer's disease related dementia;Area;Behavioral;career;Characteristics;Cognitive;cognitive function;Communities;Community Participation;critical period;Data;data access;Data Collection;Data Set;Demography;disability;Disadvantaged;Discipline;Disparity;Economics;Emotional;Faculty;Family;Fostering;Funding;Geography;Goals;Grant;Health;Health behavior;health economics;healthy aging;human old age (65+);improved;Income;Incubators;Infrastructure;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;Knowledge;late life;Lead;Leadership;Life;Life Cycle Stages;Life Experience;Location;longitudinal dataset;meetings;member;Minnesota;Monitor;Morbidity - disease rate;mortality;Neighborhoods;Outcome;Pathway interactions;Personal Satisfaction;Physical Function;Pilot Projects;Policies;Population;Population trends;Process;Program Development;programs;prospective;protective factors;recruit;Reporting;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;retiree;Risk;Scholarship;Scientist;Shapes;social;social determinants;social disparities;social engagement;Social Environment;Social support;Societies;Source;Subgroup;therapy development;Time;trend;Underrepresented Populations;Universities;Vertebral column;Vision;Work

PROJECT_TITLE: Life Course Center for the Demography and Economics of Aging


NIH_SPENDING_CATS: Aging

PI_NAMEs: MOEN, PHYLLIS E (contact)

PROJECT_TERMS: Advisory Committees;Aging;Annual Reports;Applications Grants;career;Communication;Data;data infrastructure;data sharing;Demography;Development;Economics;Educational workshop;Ensure;experience;Faculty;Funding;Goals;graduate student;Grant;Health;Human Resources;human subject;Institutional Review Boards;Interdisciplinary Study;Leadership;Letters;Life Cycle Stages;Logistics;meetings;member;Minnesota;Monitor;Outcome;Pilot Projects;Policies;Productivity;programs;Publications;recruit;Reporting;Research;research and development;Research Personnel;Research Project Grants;Research Support;Review Committee;Running;Scientist;Series;Services;Strategic Planning;Students;Surveys;symposium;Time;United States National Institutes of Health;Universities;Vertebral column;visiting scholar;Writing

PROJECT_TITLE: Life Course Center Administrative and Research Support Core


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Patient Safety;Social Determinants of Health

PROJECT_TERMS: Address;Aging;aging population;Area;Behavioral;Behavioral Research;career;Collaborations;Communities;Community Participation;Complex;Critiques;Data;data infrastructure;demographics;Demography;Development;Disparity;Economics;Ensure;Event;Family;Feedback;Fertilization;Fostering;Funding;Geography;Goals;Health;health economics;healthy aging;high reward;high risk;Home;human old age (65+);human subject;human subject protection;Human Subject Research;improved;innovation;Institution;Institutional Review Boards;interdisciplinary collaboration;Interdisciplinary Study;Investigation;late life;Life Cycle Stages;Medical Research;meetings;member;Minnesota;Mission;Modeling;Monitor;National Institute of Child Health and Human Development;novel strategies;Personal Satisfaction;Pilot Projects;Policies;Population;population based;Population trends;Program Development;programs;Protocols documentation;recruit;Research;research and development;Research Personnel;Research Support;Scholarship;Scientist;social;social engagement;Societies;Subgroup;Time;Training;Underrepresented Populations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Life Course Center Program Development Core


NIH_SPENDING_CATS: Clinical Research;Dietary Supplements;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Nutrition;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Intergenerational malnutrition is a global health challenge; the contributions of the small intestinal microbiota remain enigmatic due to the difficulty in obtaining biospecimens from malnourished children living in resource- poor settings. We have combined gnotobiotic mouse models with esophagogastroduodenoscopy (EGD) of stunted Bangladeshi children who failed a nutritional intervention to provide evidence that small intestinal bacterial taxa are causally related to their small intestinal enteropathy. This proposal seeks to delineate mechanisms by which the small intestinal microbiota contributes to maternal/child malnutrition and identify therapeutic targets and candidate therapeutic leads.

PI_NAMEs: GORDON, JEFFREY I (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Acute;Adult;Age;aged;Animal Model;Area;aspirate;Bacteria;Bangladesh;Bangladeshi;Biochemical;Biological Markers;Biological Specimen Banks;Biopsy;Birth;Body mass index;Celiac Disease;Child;child bearing;Child Malnutrition;Childhood;Classification;cohort;Collection;Colon;Consumption;COVID-19 pandemic;Culture-independent methods;Development;Diarrhea;Diet;Dietary Intervention;Disease;Distal;Duodenum;Effectiveness;egg;Endoscopy;Enteral;enteric infection;enteric pathogen;Esophagogastroduodenoscopy;Etiology;experimental study;fecal microbiota;Female of child bearing age;Food;Formulation;Functional disorder;Germ-Free;global health;Gnotobiotic;Growth;gut microbiota;Height;HIV;Human;Immune System Diseases;Impairment;improved;Incidence;Infant;Inflammation;Inflammatory Response;intergenerational;intestinal barrier;Link;Malabsorption Syndromes;Malnutrition;Mediator;member;Metabolic dysfunction;microbial community;microbiota;Micronutrients;Milk;Mothers;mouse model;Mucous Membrane;multiple omics;Mus;Nutritional status;Oligosaccharides;Oral;Organism;Peace Corps;Phenotype;Plants;Plasma;Plasma Proteins;Polysaccharides;postnatal development;Poverty;Prevalence;prevent;Prevention;Proteins;Proteome;repaired;Resource-limited setting;Role;Sampling;Slum;Small intestine mucous membrane;Small Intestines;stool sample;technology platform;Testing;Therapeutic;therapeutic candidate;therapeutic target;transmission process;Villus;volunteer;wasting;Woman

PROJECT_TITLE: The small intestinal microbiota in undernourished women and undernourished children in Bangladesh: identifying causal mechanisms and therapeutic targets

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science

PROJECT_TERMS: access restrictions;Address;Aging;aging demography;aging population;Attention;Behavioral;Behavioral Research;career;Censuses;Characteristics;Collaborations;Collection;Communication;Communities;community building;Complex;Country;Data;data access;Data Analyses;Data Collection;data infrastructure;data management;data resource;data sharing;Data Sources;Demography;design;Disparity;Economics;Educational workshop;Fostering;Funding;Geography;Health;health disparity;health economics;human capital;human old age (65+);Individual;innovation;Institution;interest;Knowledge;late life;Life;Life Cycle Stages;Life Experience;Medical Research;meetings;member;Mission;novel;Older Population;Outcome;outreach;Paper;Participant;Persons;Population;Program Development;Publishing;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Scientist;Series;social;Source;spatiotemporal;Structure;Surveys;symposium;Talents;terabyte;tool;Training;trend;Underrepresented Populations;United States National Institutes of Health;web site;working group

PROJECT_TITLE: Life Course Center External Innovative Network Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Studies in cocaine use disorders proposed in this application will further our understanding of the role of nociceptive opioid peptide (NOP) receptors in stress-induced relapse and reward-seeking behavior. These studies will inform the development of medications that target NOP to prevent relapse in addiction.

PI_NAMEs: NARENDRAN, RAJESH  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Abstinence;Acceleration;Acute;addiction;Agonist;Amphetamines;Amygdaloid structure;Animals;Anxiety;Apomorphine;Award;Behavior;Binding;Brain;Brain region;Chronic;Chronic Disease;Clinical;Cocaine;cocaine reward;Cocaine use disorder;comparison control;cooking;Corticotropin-Releasing Hormone;craving;Development;Dopamine;dopaminergic neuron;Factor X;Failure;follow-up;Goals;Hippocampus;Hydrocortisone;Image;imaging study;in vivo;Individual;interest;Intravenous;Investigation;Link;Measures;Midbrain structure;Negative Reinforcements;neurochemistry;Neuropeptides;nociceptin;Nociception;Nucleus Accumbens;Opioid Peptide;Oral;Outcome Measure;Peptide Receptor;Pharmaceutical Preparations;Positron-Emission Tomography;Prefrontal Cortex;Psychological reinforcement;radiotracer;receptor;receptor expression;Receptor Up-Regulation;receptor upregulation;Relapse;relapse prevention;resilience;response;Rewards;Rodent;Role;Scanning;Signal Transduction;Stress;Structure of terminal stria nuclei of preoptic region;Substantia nigra structure;System;therapeutic target;Time;transmission process;Ventral Striatum;Ventral Tegmental Area

PROJECT_TITLE: PET Imaging of neurochemical transmission in cocaine use disorders

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE We propose the Child Health Equity Research Program for Post-doctoral Trainees (CHERPP-T), a mentored, research project-based training program that provides didactic training in rigorous health services and clinical research methodologies, experiential research training, career development, opportunities for community- academic partnerships, and a long-term network of mentors, collaborators, and partners. The program will focus heavily on recruiting underrepresented minority (URM) trainees by leveraging existing relationships with predoctoral and early career URM pipeline programs for academic pediatricians. CHERPP-T will increase URM faculty scientists in pediatrics as well as address major gaps in child health equity research capacity, both of which will reduce inequities in child health.

PI_NAMEs: COKER, TUMAINI RUCKER (contact);MENDOZA, JASON A

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Child health equity;Health equity research;Postdoctoral Fellow;programs

PROJECT_TITLE: Child Health Equity Research Program for Post-doctoral Trainees.


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: OVERALL-NARRATIVE Organ transplantation has become a standard procedure to save the lives of patients with irreversible organ damage. One of the greatest unmet needs for improving long-term transplant outcomes is to devise safer combinatorial immune therapies that enable the specific targeting of effector alloimmune responses while augmenting the development of suppression and tolerance. These two highly synergistic projects centered on the lymph node as the critical locus of alloimmunity, seek to produce mechanistic data to lay the groundwork for developing highly targeted and innovative therapeutic strategies for transplantation.

PI_NAMEs: ABDI, REZA  (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Alloantigen;allograft rejection;Anti-Inflammatory Agents;Area;Biology;cell transformation;Cicatrix;clinical application;combinatorial;Cues;Data;Development;Dimensions;Disease;Equilibrium;fiber cell;Fostering;Generations;Goals;Graft Rejection;high voltage electron microscopy;Immune;immune activation;Immune response;Immune Tolerance;Immunity;immunoregulation;Immunosuppression;Immunotherapy;improved;improved outcome;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;Infrastructure;inhibitor;innovation;isoimmunity;Laminin;Light;lymph node microenvironment;lymph nodes;Mediating;member;Microanatomy;Modeling;Molecular;Monoclonal Antibodies;Myofibroblast;Nanodelivery;nanoparticle;Nature;novel;Organ;Organ Transplantation;Outcome;Pathway interactions;Patients;Play;Procedures;programs;Reaction;Regulation;Regulatory T-Lymphocyte;Research Personnel;Resources;response;Rest;restoration;Reticular Cell;Role;Scientist;senescence;senolytics;Site;skills;Solid;Stromal Cells;Structure;Subcellular Anatomy;synergism;T memory cell;T-Lymphocyte;targeted delivery;targeted treatment;Technology;Testing;Therapeutic;TNFSF5 gene;translational applications;Transplantation;Transplantation Tolerance

PROJECT_TITLE: Lymph nodes at the crossroads of allo immunity and regulation


PHR: Core A- Narrative Administrative Core A will provide administrative coordination of scientific activities and ensure effective communication for the entire program. Core A will also be responsible for budget handling, accounting and monitoring of expenditures, as well as preparation of annual budgets for renewals.

PROJECT_TERMS: Accounting;Administrative Coordination;animal care;Bibliography;Budgets;Calendar;Communication;data integration;data sharing;Disputes;Ensure;Expenditure;Funding;Goals;Grant;IACUC;Immunity;Individual;Institutional Review Boards;Joints;Laboratories;lymph nodes;Maintenance;Manuscripts;meetings;member;Monitor;Occupational activity of managing finances;Participant;performance site;Play;Preparation;preservation;programs;Progress Reports;Protocols documentation;Records;Regulation;Research;Research Personnel;Resolution;Role;Scientific Advances and Accomplishments;scientific organization;Shipping;Specialist;Structure;success;symposium;synergism;Travel;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Admin Core


PHR: CORE B- Narrative Core B will be responsible for synthesizing and characterizing the NPs and FRCs. Core B will be utilized by both projects.

PROJECT_TERMS: absorption;Alloantigen;allograft rejection;Anti-Inflammatory Agents;Antibodies;antibody conjugate;Area;Autoimmune Diseases;Biology;Biomedical Engineering;Blood;Capsid Proteins;Cell Separation;Cells;Characteristics;Collagen;Conjugated Carrier;cytokine;Data;design;Dimensions;Drug Delivery Systems;Drug Targeting;Dyes;Engineering;Equilibrium;experience;experimental study;fiber cell;Fibronectins;Fibrosis;Goals;High Endothelial Venule;Immune;immune activation;immune modulating agents;Immune response;Immune Tolerance;Immunity;immunoregulation;Immunotherapeutic agent;in vivo;Inflammatory;Inflammatory Response;innovation;insight;intradermal injection;L-Selectin;laminin alpha5;lymph nodes;Lymphatic;Lymphocyte;lymphocyte trafficking;Microanatomy;migration;Molecular;Monoclonal Antibodies;multidisciplinary;Mus;Myofibroblast;Nanodelivery;nanoformulation;nanoparticle;nanoparticle delivery;Nature;novel;Organ;Organ Transplantation;particle;Pathogenesis;Peripheral;Phenotype;Play;prevent;programs;Quality Control;Reaction;receptor;Regulation;Regulatory T-Lymphocyte;response;Reticular Cell;Role;senolytics;Shapes;sialyl Lewis x;Signal Transduction;Signaling Molecule;stem;Stromal Cells;sugar;Sulfate;Surface;T-Lymphocyte;targeted delivery;Techniques;Therapeutic;Time;Tissues;TNFSF5 gene;trafficking;Transplantation;Transplantation Tolerance;Tumor Immunity;venule;virtual

PROJECT_TITLE: Core B


NIH_SPENDING_CATS: Lymphatic Research;Organ Transplantation;Regenerative Medicine;Transplantation

PHR: Public Health Relevance Statement Organ transplantation is a gold standard treatment that has saved the lives of patients with irreversible organ damage. The goal of this proposal is to generate highly innovative data that will address the key unmet clinical need to devise highly specific, targeted immune therapies for transplantation.

PROJECT_TERMS: Adopted;Alloantigen;allograft rejection;Anti-Inflammatory Agents;Cell Aging;Cell Physiology;Cell Transplantation;Cells;Characteristics;chemokine;Cicatrix;Clinical;Collagen;conditional knockout;Cues;cytokine;Data;Dendritic Cells;Deposition;Dimensions;draining lymph node;Drug Delivery Systems;Drug Targeting;Equilibrium;Extracellular Matrix;Fibronectins;Fibrosis;Future;Generations;Goals;Graft Rejection;Heart Transplantation;high voltage electron microscopy;Homing;Immune Targeting;Immunity;Immunologics;immunoregulation;in vivo;infancy;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Investigation;isoimmunity;Knock-out;Knockout Mice;Light;lymph node microenvironment;lymph nodes;Mediating;Mesenchymal;Molds;multidisciplinary;Mus;Myofibroblast;novel;Organ;Organ Transplantation;Outcome;Pathogenesis;Pathway interactions;Patients;Peripheral;Phenotype;Play;Positioning Attribute;prevent;Process;Production;programs;Property;public health relevance;Reaction;Regulation;Regulatory T-Lymphocyte;response;restoration;Reticular Cell;Role;senescence;senescence associated secretory phenotype;senolytics;Signal Pathway;Signal Transduction;standard care;Stromal Cells;Structure;Supporting Cell;Surface;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Time;transplant model;Transplantation;transplantation therapy;Transplantation Tolerance

PROJECT_TITLE: HVEM pathway regulating FRC function and transplant tolerance


PHR: Project Narrative Achieving tolerance remains the most important goal in transplantation. The significance of the current proposal is that it will define the function and mechanisms of specialized stromal cells and stromal structures in the lymph node that determine transplantation tolerance, and how they determine the choice between immunity versus tolerance. The findings from these investigations will have general applicability to other areas of immunology such as infection, vaccination, and autoimmunity.

PI_NAMEs: BROMBERG, JONATHAN S (contact)

PROJECT_TERMS: Alloantigen;anergy;Antibodies;Antigens;Area;Autoimmunity;Blood Vessels;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Maturation;cell motility;Cell Physiology;Chimeric Proteins;Data;Dendritic Cells;Development;effector T cell;Environment;Equilibrium;experience;Formulation;FOXP3 gene;Goals;Graft Rejection;Graft Survival;Graft Tolerance;heart allograft;Heart Transplantation;High Endothelial Venule;Home;Immune response;Immunity;Immunology;Infection;Inflammation;Inflammatory;innovation;Investigation;Knock-out;knockout gene;Laboratories;Laminin;laminin alpha5;lymph node medullary portion;lymph node microenvironment;lymph nodes;lymphotoxin beta receptor;Microanatomy;migration;Molecular;Monoclonal Antibodies;mouse model;Mus;nanoparticle;neutralizing antibody;Pathway interactions;Play;Population;Production;programs;receptor;Receptor Activation;Receptor Signaling;Regulation;Regulatory T-Lymphocyte;response;Reticular Cell;Role;Shapes;Signaling Molecule;single-cell RNA sequencing;Spleen;Stromal Cells;Structure;T cell differentiation;T cell response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;targeted delivery;targeted treatment;TNFRSF5 gene;TNFSF5 gene;Transplantation;Transplantation Tolerance;Vaccination

PROJECT_TITLE: Reshaping lymph node stroma for transplant tolerance


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Genetics;Neurosciences;Substance Misuse;Tobacco

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Tobacco dependence is a leading cause of premature death and disease in the United States. We have shown that medial habenula neurons that project to the interpeduncular nucleus play a critical role in regulating the motivational properties of nicotine. In new findings, we show that the transcription factor Tcf7l2 acts in the habenula to exert profound control over nicotine intake. Here, we will use cutting-edge molecular, cellular and behavioral approaches to understand the mechanisms by which Tcf7l2 acts. This program of research promises to identify new classes of targets for the development of therapeutic agents to aid smoking cessation.

PI_NAMEs: KENNY, PAUL J. (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Behavior;Behavioral;Brain;Calcium;calcium indicator;Candidate Disease Gene;Cell Nucleus;cell type;Cells;Cessation of life;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;Consumption;Coupled;Data;desensitization;Disease;Electrophysiology (science);Fiber;Funding;Gene Deletion;Gene Expression;gene network;Genes;Genetic;Genetic Transcription;GLP-I receptor;glucagon-like peptide 1;Glutamates;Habenula;High-Throughput Nucleotide Sequencing;Image;in vivo;inducible Cre;Infusion procedures;innovation;insight;Intake;interpeduncular nucleus;Intravenous;knock-down;Knock-out;Knockout Mice;Measures;Medial;Mediating;Molecular;Monitor;Motivation;Mus;neurobiological mechanism;Neurobiology;Neurons;Neuropeptides;Nicotine;nicotine cessation;Nicotine Dependence;nicotine reward;nicotine self-administration;nicotine use;Nicotinic Receptors;Nucleus solitarius;optogenetics;Pharmaceutical Preparations;pharmacologic;Photometry;Play;Population;premature;programs;Property;protein expression;Psychological reinforcement;Rattus;receptor function;Research;response;RNA Interference;Role;Satiation;sensor;Signal Transduction;smoking cessation;System;TCF7L2 gene;Testing;therapeutic development;Tissues;Tobacco Dependence;transcription factor;transcriptome sequencing;transmission process;United States;Virus;Wild Type Mouse

PROJECT_TITLE: Mechanisms of nicotine reinforcement


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PUBLIC HEALTH RELEVANCE We will develop a comprehensive multi-omic, phenomic, and trans-ethnic computational methodology that bridges the gap between Genetic Epidemiology and Functional Genomics. This research provides a rigorous framework for investigating relevant mechanisms underlying complex traits, including disease risk and quantitative traits. We will leverage and integrate high- dimensional molecular data, electronic health records, and genetic studies in diverse populations.

PI_NAMEs: GAMAZON, ERIC R (contact)

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Acceleration;Address;Algorithms;All of Us Research Program;Alleles;biobank;Biological;Catalogs;causal model;cell type;Chromatin;comorbidity;Complex;computerized tools;Computing Methodologies;Data;data repository;Data Set;deep learning;Development;Discipline;Disease;disorder risk;DNA;Electronic Health Record;Ethnic Origin;Ethnic Population;Expression Profiling;functional genomics;Gene Expression;Genetic;genetic analysis;genetic architecture;genetic association;genetic epidemiology;Genetic study;genetic variant;Genetic Variation;genome resource;genome wide association study;genomic data;Genomic medicine;Genomics;Heterogeneity;high dimensionality;histone modification;Human;Human Genetics;human genomics;Image;improved;Link;Machine Learning;Mendelian randomization;Methodological Studies;Methodology;Methylation;Modeling;Molecular;Molecular Analysis;multi-ethnic;multiple omics;Nature;novel therapeutic intervention;Performance;phenome;phenomics;Phenotype;pleiotropism;Population;Population Heterogeneity;precision medicine;predictive modeling;Proteins;public health relevance;recruit;Regulation;Regulatory Element;repository;Research;Research Proposals;response;RNA;Robotics;Single Nucleotide Polymorphism;Software Tools;Therapeutic;Tissues;Training;trait;transcriptome;Translational Research;Underrepresented Populations;Variant

PROJECT_TITLE: Advancing Multi-Omics and Electronic Health Records Computational Methodologies

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Eye Disease and Disorders of Vision;Neurosciences;Substance Misuse

PHR: PROJECT NARRATIVE The basal ganglia, including dopamine neurons, are crucial for learning about stimuli that predict rewards (cues), but it is not understood how this system receives sensory information needed to guide cue-based learning. Here, I use new techniques for mapping and manipulating brain circuits to investigate the role of projections from the superior colliculus, an evolutionarily ancient visual structure, to the dopamine system in the transformation of sensation to action.

PI_NAMEs: POISSON, CARLI L (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: addiction;Address;Anatomy;Anesthesia procedures;Animals;Attention;Attention deficit hyperactivity disorder;Basal Ganglia;Behavior;Behavioral;behavioral response;Brain;Calcium;Cells;Communication;Complex;Corpus striatum structure;Decision Making;defined contribution;directed attention;Discrimination;Discrimination Learning;discrimination task;Dopamine;dopamine system;dopaminergic neuron;Dorsal;Environment;Esthesia;experimental study;Fiber;Genetic;Heterogeneity;Impairment;in vivo;insight;Knowledge;Label;Lateral;Learning;Learning Disabilities;Literature;Locomotion;Maps;Measurement;Measures;Medial;Mediator;Mental disorders;Methods;Midbrain structure;Motivation;Motor;Movement;neural;neural circuit;neurobiological mechanism;neuronal circuitry;Neurons;Neurosciences;novel;Nucleus Accumbens;Optics;optogenetics;Outcome;pars compacta;Pathway interactions;pharmacologic;Photometry;Play;prevent;Process;Rattus;response;Retina;reward processing;Rewards;Role;sensor;Sensory;sensory discrimination;Sensory Disorders;sensory input;sensory integration;sensory processing disorder;Stimulus;Structure;Substance Use Disorder;Substantia nigra structure;superior colliculus Corpora quadrigemina;Synapses;System;Testing;tool;Training;Use of New Techniques;Ventral Tegmental Area;Viral;Visual;visual discrimination;visual stimulus

PROJECT_TITLE: Characterizing superior colliculus inputs to midbrain dopamine centers in cue learning


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Lung;Women's Health Research

ORG_CITY: MADISON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Although many women with estrogen receptor positive (ER+) primary cancers are successfully treated with surgery and adjuvant anti-estrogen therapies, metastatic ER+ cancers account for the majority of breast cancer related deaths. Lack of in vivo models with an intact immune system has impeded our understanding of how factors, including estrogen itself, orchestrate cooperation between tumor cells and other cells in the environment to drive local disease and promote metastasis. The goal of our proposed studies utilizing an immunocompetent mouse model of aggressive ER+ disease, complemented by study of clinical samples, is to illuminate the effects of estrogen on dissemination and lung metastatic colonization in ER+ breast cancer. These studies have implications for breast cancer therapy, dormancy and recurrence, and the potential to reveal sites for intervention.

PI_NAMEs: PONIK, SUZANNE MARIE;SCHULER, LINDA A. (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Address;Adjuvant;Adjuvant Therapy;Aftercare;Aggressive behavior;antagonist;Anti-estrogen Therapy;Architecture;Automobile Driving;Biology;Biopsy;Breast Cancer therapy;cancer cell;cancer recurrence;cell growth;cell motility;Cells;Cessation of life;Clinical;Collagen;Collagen Fiber;Complex;conditioning;cytokine;density;Diagnosis;Disease;Distant;Environment;Equilibrium;ESR1 gene;Estrogen receptor positive;Estrogen Receptors;Estrogen Therapy;Estrogens;Exhibits;Experimental Models;Exposure to;Extracellular Matrix;Fibroblasts;Goals;Grant;Growth;Hormonal;hormonal signals;hormone therapy;Hormones;Immune;Immune system;Immunocompetent;immunoregulation;In Vitro;in vitro Model;in vivo;in vivo Model;infiltrating duct carcinoma;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Intervention;Invaded;Knowledge;Lesion;Localized Disease;Lung;lung lesion;lung metastatic;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Mediator;Modeling;mortality;mouse model;Neoplasm Metastasis;neoplastic cell;novel strategies;Operative Surgical Procedures;patient derived xenograft model;Patients;Population;Primary Neoplasm;Process;Prognosis;PTGS2 gene;receptor;Recurrence;Residual state;response;Role;Sampling;Signal Transduction;Site;standard of care;Structure;synergism;System;Tamoxifen;Testing;Therapeutic;therapy resistant;Tissues;trafficking;treatment response;tumor;Tumor Cell Invasion;Tumor Cell Migration;tumor microenvironment;tumor progression;Tumor Promotion;tumor-immune system interactions;tumorigenic;Woman

PROJECT_TITLE: Matrix density promotes pro-tumorigenic hormone actions in breast cancer

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative In the U.S., cancer has become the leading cause of death in the aging HIV-positive population. In this application, we propose to investigate targets that impinge on the PI3K/Akt/mTOR pathway in KSHV- associated cancers. These investigations will uncover the next generation of therapies against KS and lymphoma in the context of HIV infection.

PI_NAMEs: DAMANIA, BLOSSOM A;DITTMER, DIRK P (contact)

PROGRAM_OFFICER_NAME: LIDDELL HUPPI, REBECCA

PROJECT_TERMS: ABCB1 gene;Acquired Immunodeficiency Syndrome;Africa South of the Sahara;Age;age related;Aging;AIDS related cancer;AIDS-Related Lymphoma;AKT inhibition;Animal Model;antiretroviral therapy;antitumor effect;Biological;cancer cell;cancer therapy;Caring;Cause of Death;Chemoresistance;Clinical;clinical development;Clinical Trials;cohort;Combined Modality Therapy;Complex;CRISPR screen;Cytostatics;cytotoxic;Data;Derivation procedure;Disease;Drug Efflux;efflux pump;Endothelial Cells;Exhibits;experimental study;FDA approved;FRAP1 gene;Funding;Generations;Genomics;Goals;Grant;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV therapy;HIV/AIDS;Human;Human Herpesvirus 8;Immunodeficient Mouse;immunoregulation;in vivo;in vivo imaging;Incidence;Individual;inhibitor;innovation;insight;Investigation;Kaposi Sarcoma;Life;Link;Lymphoma;Malignant Neoplasms;Modeling;Molecular;mouse model;mTOR inhibition;mTOR Inhibitor;mTOR Signaling Pathway;new therapeutic target;next generation;novel;Organ Transplantation;Pathway interactions;Persons;Pharmaceutical Preparations;Phase;Phosphotransferases;PIK3CG gene;Population;pre-clinical;preclinical study;primary effusion lymphoma;Publications;Relative Risks;Reporting;Research;Resistance;Resistance development;resistance mechanism;Risk;Role;Safety;SDZ RAD;seropositive;Signal Transduction;Sirolimus;standard of care;success;targeted treatment;Testing;therapeutic target;therapy resistant;Time;Transplantation;tumor;United States;Viral Cancer;Viral Load result;whole genome;Work

PROJECT_TITLE: Targeted Therapies for HIV-Associated Kaposi Sarcoma and Lymphoma

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Clinical Research;Cocaine;Data Science;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Stimulant Use and Misuse;Substance Misuse

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE With the success of antiretroviral therapy (ART) and public health strategies to reduce new HIV infections, much of the HIV burden in developed countries is now as a chronic disease, including among drug users. Cocaine is one of the most frequently abused illicit drugs among HIV+ individuals and is known to worsen HIV progression, even with ART, and is likely to increase the latent reservoir of virus: the latent reservoir blocking efforts for an HIV cure. We will apply cutting-edge big data techniques across multiple genome-wide data types and cohorts to produce important new insights into key elements of HIV as a chronic disease among cocaine users, providing a basis for improved treatment and identification of targets for new medication development.

PI_NAMEs: JACOBSON, DANIEL A;JOHNSON, ERIC OTTO (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Address;Affect;Algorithms;antiretroviral therapy;Big Data;Bioinformatics;Biological;Biological Process;Biology;Chromosome Mapping;Chronic Disease;Cocaine;Cocaine Abuse;Cocaine Users;cohort;Complex;Computational Biology;Custom;Data;Data Set;Developed Countries;Development;Disease;DNA Methylation;Drug abuse;Drug user;Elements;explainable artificial intelligence;Gene Expression Regulation;gene network;gene regulatory network;Genes;Genetic Epistasis;Genetic Predisposition to Disease;genetic variant;Genome;genome wide association study;genome-wide;Genotype;Genotype-Tissue Expression Project;Goals;HIV;HIV Infections;Illicit Drugs;improved;Incidence;Individual;Information Networks;innovation;insight;Internet;Joints;Laboratories;Maps;Mediating;Methods;methylome;Molecular;mRNA Expression;Multiomic Data;multiple omics;Network-based;novel;Oranges;Outcome;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;Population;Principal Investigator;Production;Public Health;random forest;Research Design;Resources;response;Sampling;Signal Transduction;Source;success;supercomputer;Surface;symposium;Techniques;transcriptome;transcriptome sequencing;Variant;Viral;Viral Load result;Viral reservoir;Virus Latency;Woman

PROJECT_TITLE: Gene Network Identification and Integration (GNetii) Approach to Understanding the Biology Underlying HIV and Drug Abuse.


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: The proposed study will inform prevention science, and contribute to reducing health disparities among Hispanic adolescents, by identifying physiological mechanisms that explain the effects of cultural stressors on alcohol/drug use and conduct problems in this population. The study will also identify protective mechanisms that can be targeted in preventive interventions. An innovative two-site (Miami and Los Angeles) design will be used to ascertain generalizability of findings across different geographic areas.

PI_NAMEs: SCHWARTZ, SETH J. (contact);UNGER, JENNIFER BETH

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Acceleration;adaptive intervention;Adolescent;Adrenal Glands;Age;Alcohols;Behavioral;Biological;biological adaptation to stress;Biological Assay;Buffers;Cardiovascular Diseases;Chronic;Chronic stress;Climate;cohort;Communities;conduct problem;County;Crime;Data Collection;design;Destinations;Development;Discrimination;disparity reduction;Documentation;Drug usage;Economics;ethnic minority population;Ethnic Origin;evidence base;experience;Exposure to;Family;Family member;Feeling;food insecurity;Friends;Future;Geographic Locations;Health;health disparity;Hispanic;Hispanic Populations;Hostility;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Immigration;Individual;innovation;Intervention;Life;Link;Longitudinal cohort study;longitudinal design;Longitudinal Studies;Los Angeles;Low income;Measurement;Measures;Mediating;Mediation;Mental Depression;Mood Disorders;ninth grade;Obesity;Outcome;Parents;Pathway interactions;Patient Self-Report;Pattern;Persons;physical conditioning;Physiological;Pituitary Gland;poor health outcome;Population;Poverty;preservation;Prevention;Prevention program;preventive intervention;Problem behavior;psychosocial;recruit;Reduce health disparities;Research Design;Resources;response;Risk Behaviors;saliva sample;Salivary;sample collection;Science;seventh grade;Site;skills;social;Socialization;Source;Stress;stressor;substance use;Technology;Testing;theories;Time;Violence;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Cultural Stress, Stress Response, and Substance Use among Hispanic Adolescents

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Lung;Prevention;Rheumatoid Arthritis

ORG_CITY: BOSTON

PHR: PROJECT NARRATIVE Rheumatoid arthritis (RA) is a common chronic autoimmune disease consisting of inflammatory arthritis. Patients with RA are susceptible to developing interstitial lung disease (ILD), which results in substantial excess morbidity and mortality. This research will investigate whether RA-related autoantibodies and articular inflammation contribute to subclinical and clinically apparent RA-ILD across the disease course of RA (pre-RA, early RA, established RA). Discoveries made through this research are directly relevant to the National Institutes of Health’s mission by providing insight into RA and RA-ILD pathogenesis that may ultimately lead to RA-ILD screening and prevention strategies for this devastating complication of RA.

PI_NAMEs: SPARKS, JEFFREY ANDREW (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Acetaldehyde;Adult;Affect;arthritis registry;Autoantibodies;Autoimmunity;Award;biobank;Chest;chest computed tomography;chronic autoimmune disease;chronic pain;Clinical;clinical risk;cohort;Colorado;Complication;cyclic citrullinated peptide;Data;Data Set;Derivation procedure;Detection;Development;disability;Disease;disease phenotype;Disease susceptibility;disorder risk;Etiology;Excess Mortality;Exposure to;Fibrosis;Foundations;Funding;General Hospitals;Genetic;Genotype;Glass;Goals;High Resolution Computed Tomography;high risk;Hospitals;Image;improved;Inflammation;Inflammatory Arthritis;Inhalant dose form;insight;Interstitial Lung Diseases;Investigation;Isoenzymes;Joints;Life Style;Link;Liquid substance;Lung;lung injury;Malondialdehyde;Massachusetts;Measures;medical schools;Medicine;Michigan;Mission;Morbidity - disease rate;mortality;MUC5B gene;Mucous Membrane;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;neoantigens;Nested Case-Control Study;Observational Study;Outcome;Pain;participant enrollment;Pathogenesis;Patient Recruitments;patient registry;patient stratification;Patients;Performance;Phenotype;Post-Translational Protein Processing;predictive modeling;Predisposition;prevent;Prevention strategy;Process;Production;professor;promoter;prospective;Prospective cohort;Protein-arginine deiminase;Proteins;Pulmonary Inflammation;Registries;Research;Research Personnel;Rheumatoid Arthritis;Rheumatoid Factor;Risk;Risk Factors;Role;Scanning;screening;seropositive;Serum;Site;Smoker;Smoking;Smoking History;Sputum;Surface;Symptoms;systemic autoimmune disease;systemic inflammatory response;Testing;United States National Institutes of Health;Universities;Variant;Woman;X-Ray Computed Tomography

PROJECT_TITLE: Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung Disease

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: ALBANY

ORG_DEPT: CHEMISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: PROJECT NARRATIVE: The proposed research is relevant to the public health because cyclic peptides and glycoproteins exist ubiquitously in the pharmaceuticals and biologics. Despite significant advances in chemical studies of protein preparation, homogenous membrane glycoproteins are difficult to obtain. Upon conclusion, we will provide a powerful tool for the protein function elucidation and investigation.

PI_NAMEs: ZHANG, QIANG  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: adduct;Amides;Amino Acids;Biological;Biological Process;Biological Products;Cell Physiology;chemical synthesis;Chemicals;Coupling;Cyclic Peptides;design;epimerization;Esters;Evaluation;flexibility;Geometry;Glycoproteins;Goals;Individual;Investigation;Lactones;Ligation;Membrane;Membrane Glycoproteins;Molecular Conformation;Oxazolone;Peptide Synthesis;Peptides;Periodicity;Pharmacologic Substance;Preparation;prevent;Prion Diseases;Prions;protein function;Proteins;Protocols documentation;PrP;PrPSc Proteins;Public Health;Publishing;Research;Testing;tool

PROJECT_TITLE: The chemical approach towards homogenous glycoprotein preparation and evaluation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]