NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Cognitive resilience to Alzheimer’s disease (AD) and brain aging is a phenomenon whereby an individual’s cognitive functioning is better than predicted based on chronological age, genetic risk, and/or advanced neuropathology. Understanding the protective factors that improve cognitive resilience requires comprehensive identification of the protein components of unique brain cell types – an analysis that cannot be performed longitudinally in human patients. In this project, we will combine human clinical and molecular data with proteomic data from neurons and immune cells from the hippocampus of mice that are resilient and susceptible to cognitive decline to identify novel proteins and complexes that could ultimately be therapeutically targeted to delay or prevent cognitive symptoms in AD patients.

PI_NAMEs: KACZOROWSKI, CATHERINE COOK (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Age;age difference;Aging;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amino Acids;Amyloid;asymptomatic Alzheimer's disease;Attention;Autopsy;Behavior;behavioral phenotyping;brain cell;brain tissue;candidate identification;cell type;Cells;Chronology;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;Cognitive aging;Cognitive deficits;cognitive function;cohort;Communities;Complex;Data;data integration;Data Set;Databases;Disease;Disease Progression;DNA;drug discovery;Electrophysiology (science);Environmental Risk Factor;Exhibits;familial Alzheimer disease;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic approach;Genetic Engineering;Genetic Risk;Genetic Transcription;Genetic Variation;Genomics;Grant;Hand;high dimensionality;high risk;Hippocampus;Human;human data;Human Genetics;Human Genome;human model;human tissue;Immune;Impaired cognition;improved;Individual;Ion Channel;Knowledge;knowledge base;Knowledge Portal;Label;Late Onset Alzheimer Disease;Learning;Link;Mediating;Memory;Memory impairment;Meta-Analysis;Methods;Microglia;Molecular;Molecular Analysis;Molecular Target;mouse model;Mouse Strains;multidimensional data;Mus;Mutation;Neurobehavioral Manifestations;neuroinflammation;neuronal excitability;Neurons;neuropathology;novel;Pathology;Pathway interactions;Patients;Phenotype;Population;Predisposition;prevent;promote resilience;protective factors;Protein Biosynthesis;protein expression;protein protein interaction;Proteins;Proteome;Proteomics;Research;resilience;resilience factor;resilience in aging;Resources;response;RNA;Sampling;segregation;Shiga-Like Toxin I;spatial memory;Synapses;synaptic function;Synaptic plasticity;System;tau Proteins;Technology;Testing;therapeutic target;Time;Transcript;transcriptomics;Translating;usability;Variant;Work

PROJECT_TITLE: Cell Type-Specific Proteins that Promote Resilience to Cognitive Aging and Alzheimer's Disease (Suppl)


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: Nashville

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: We uncovered a novel virulence function of the SARS-CoV-2 Nsp1 protein that results in inhibition of host gene expression, including those encoding antiviral factors, via targeting the cellular mRNA nuclear export pathway. Understanding how the mRNA nuclear export machinery is targeted by SARS-CoV-2 is of critical importance to understand viral pathogenicity and will reveal novel information on the molecular interactions leading to mRNA export and on the host antiviral defense mechanisms. Our studies may also aid in the development of novel therapeutic strategies that target Nsp1 function during SARS-CoV-2 infection.

PI_NAMEs: FONTOURA, BEATRIZ MA;GARCIA-SASTRE, ADOLFO ;REN, YI  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Address;Animal Model;Anti-viral Agents;Anti-viral Response;Attenuated;Binding;Binding Sites;Biochemical;Biochemistry;Biological;Biological Assay;Biophysics;Cell Nucleus;Cell Physiology;Cells;Cellular biology;cellular targeting;Complex;Coronavirus;COVID-19 outbreak;COVID-19 pandemic;Cytoplasm;Cytoplasmic Protein;Data;Defense Mechanisms;design;Development;Gene Expression;Genes;genetic approach;Genetic Polymorphism;Genetic Transcription;Hamsters;imaging approach;Immune response;inhibitor;Innate Immune Response;insight;interdisciplinary approach;Knowledge;Laboratories;Life Cycle Stages;loss of function;Mediating;member;Messenger RNA;Molecular;mRNA Export;mRNA Expression;Mus;mutant;Mutation;Nonstructural Protein;novel;novel therapeutic intervention;Nuclear;Nuclear Export;Nuclear Import;Nuclear Pore Complex;Pathogenesis;Pathogenicity;Pathway interactions;Principal Investigator;protein function;Proteins;Proteomics;receptor;recombinant virus;Recombinants;Regulation;response;Role;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;Site;structural biology;Structure;Topical application;Translations;Travel;variants of concern;Viral;Viral Pathogenesis;Viral Proteins;virology;Virulence;Virulence Factors;Virus;Virus Replication

PROJECT_TITLE: mRNA Nuclear Export Machinery as Target of SARS-CoV-2 Nsp1 Protein

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Wound Healing and Care

ORG_CITY: BOSTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Basal epithelial cells play critical roles in maintaining a healthy corneal epithelium and are responsible for wound healing after corneal injury. We propose to characterize the diversity of basal epithelial cells in the central cornea, limbus, and conjunctiva and their roles in homeostasis and wound healing. Successful completion of this study will advance our understanding of the maintenance of a healthy corneal epithelium and reveal new targets for the treatment of severe corneal epithelial defects.

PI_NAMEs: SASAMOTO, YUZURU  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Adhesions;Apoptosis;Architecture;Basal Cell;Basement membrane;Blindness;Brain-Derived Neurotrophic Factor;Cell Adhesion Molecules;Cell Differentiation process;cell motility;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cicatrix;conjunctiva;Cornea;corneal epithelial wound healing;corneal epithelium;Corneal Injury;Data;Defect;diabetic;differential expression;Disease;Dry Eye Syndromes;Epithelial Cells;epithelial stem cell;Equilibrium;experience;experimental study;Extracellular Matrix;Focal Adhesions;Gap Junctions;gene function;Genes;GJB6 gene;Goals;healing;Health;Heterogeneity;Homeostasis;Human;In Situ;Individual;intercellular communication;Interstitial Collagenase;Keratopathy;knock-down;Knock-out;knockout gene;Laminin;Ligands;Light;limbal;Location;Maintenance;Mechanics;migration;Molecular;molecular phenotype;Mus;neurotrophin 4;new therapeutic target;novel;NTRK2 gene;ocular surface;Osmotic Pressure;overexpression;Pain;Pattern;Persons;Phenotype;Photophobia;Play;Primary Cell Cultures;Proliferating;Recurrence;Regulation;Reporting;Resistance;response;Role;Signal Pathway;Signaling Protein;single-cell RNA sequencing;stem cells;Stratification;stromelysin 2;Testing;Tissues;transcriptomics;Trauma;Ulcer;Vision;Visual Acuity;wound healing

PROJECT_TITLE: The role of BCAM-positive cells in central cornea, limbus and conjunctiva

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Precision Medicine has now been firmly incorporated into the routine standard-of-care in many medical specialties, in stark contrast with Psychiatry where quantitative predictors that guide clinical decision-making remain extremely limited. Our proposed studies aim to advance the goals of Precision Psychiatry by using artificial intelligence to build clinical outcome predictors of psychosis through integration of electronic health records, dimensional phenotyping, and genetic information, in addition to exploring the psychosocial impact on patients and clinicians. Our long-term goal is to advance the tools available for personalized approaches to diagnosis, treatment, and prognosis in mental health.

PI_NAMEs: FINNERTY, MOLLY T (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Address;Antipsychotic Agents;Artificial Intelligence;Attitude;biobank;cardiometabolism;Classification;CLIA certified;Clinical;clinical decision-making;clinical implementation;clinical practice;clinical predictive model;clinical predictors;clinical subtypes;Code;Cognition;cohort;comorbidity;Computer Analysis;Consensus;Consent;Copy Number Polymorphism;Data;Data Analytics;Data Collection;Database Management Systems;Databases;Diabetes Mellitus;diabetes risk;Diagnosis;Diagnostic;Dimensions;Disease;DNA;Electronic Health Record;emotional reaction;Ethics;experience;Future;Genetic;genetic analysis;Genetic Counseling;genetic information;genome sequencing;genomic data;Goals;Impairment;improved;Individual;individual patient;individualized medicine;Institutionalization;Insurance;Interview;Knowledge;Life;long term hospitalization;Machine Learning;Medicaid;Medical;medical specialties;Medicine;meetings;Mental Health;Methods;model building;Modeling;Monitor;mortality;multidisciplinary;Nature;New York;novel;Outcome;outcome prediction;Pathogenicity;Patient Recruitments;patient subsets;Patients;Perception;personalized approach;Persons;Pharmacological Treatment;Phenotype;phenotypic data;Population;Population Database;precision medicine;predict clinical outcome;predictive modeling;preventive intervention;Prognosis;prognostic;prospective;Psychiatry;Psychoses;psychosocial;Public Health;rare variant;Recovery;recruit;Refractory;Research;Resistance;Resource Allocation;Risk;Sampling;Schizophrenia;Services;severe mental illness;Severity of illness;side effect;Site;social health determinants;standard of care;Study models;Surveys;System;tool;treatment optimization;treatment planning;treatment response;Untranslated RNA;Validation;Variant;whole genome

PROJECT_TITLE: 3/5 Clinical Outcome Prediction of Psychosis from Electronic Health Records (COPPER)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-E (60)]


ADMINISTERING_IC: HL

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular

ORG_CITY: CLEMSON

ORG_DEPT: NUTRITION

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE  Public Health Relevance Atherosclerosis kills more people than any other disease and is caused by cholesterol accumulating in arteries. Removing excess cholesterol from vascular smooth muscle cells in arteries may prevent atherosclerosis. Our proposed studies will use strategies that alter cholesterol removal pathways precisely in vascular smooth muscle cells, which may lead to the development of effective atherosclerosis treatments.

PI_NAMEs: STAMATIKOS, ALEXIS  (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Aorta;Area;Arterial Fatty Streak;Arterial Intimas;Arterial Medias;Arteries;atheroprotective;Atherosclerosis;ATP binding cassette transporter 1;ATP-Binding Cassette Transporters;Cause of Death;Cell Culture System;Cell Lineage;cell type;Cells;Cessation of life;Cholesterol;Cultured Cells;Cytoprotection;Data;Development;Disease;Down-Regulation;effective therapy;Excision;Exhibits;Foam Cells;Future;Goals;High Density Lipoproteins;Impairment;in vivo;Knock-out;Laboratories;Lesion;Lipids;Macrophage;Mediating;migration;Modeling;mouse model;Mus;Myocardial Infarction;novel;novel strategies;overexpression;Pathway interactions;Persons;Phenotype;Population;preservation;prevent;public health relevance;Reporting;Smooth Muscle Myocytes;stem cell population;Stroke;Testing;transdifferentiation;Up-Regulation;Vascular Smooth Muscle

PROJECT_TITLE: Identifying novel atheroprotective mechanisms

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_STATE: MI

PHR: The goal of this proposal is to improve the delivery of agents that increase or decrease gene expression – which are named anti-sense oligonucleotides – in a selective and non-invasive manner to neurons in the brain. This research will involve conjugating anti-sense oligonucleotides to binding proteins (antibodies) that penetrate the blood-brain barrier, target proteins on neurons, release their conjugated agents after cellular internalization, and modulate gene expression. Successful completion of this research would enable a broad range of fundamental neuroscience and therapeutic applications, including treating diseases such as Dravet syndrome and other brain disorders.

PI_NAMEs: TESSIER, PETER M;THURBER, GREG  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Amino Acid Transport System L;Antibodies;antibody conjugate;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Astrocytes;Azides;Behavior;Behavioral;Binding Proteins;Bispecific Antibodies;Blood - brain barrier anatomy;blood-brain barrier penetration;Brain;brain cell;Brain Diseases;brain parenchyma;Brain region;Cell Surface Proteins;cell type;Cells;CHRM3 gene;conditioned fear;Conjugating Agent;dentate gyrus;Development;Disease;disease phenotype;dravet syndrome;efficacy evaluation;efficacy testing;Electrophysiology (science);experimental study;Fluorescent in Situ Hybridization;Gene Expression;Gene Silencing;gene therapy;Generations;Genes;Goals;GPM6A gene;granule cell;Hippocampus;Immunoglobulin G;improved;inhibitory neuron;Injections;intravenous administration;Knock-out;MALAT1 gene;Mediating;method development;Microglia;Molecular;mouse model;Mus;Names;Neurons;Neurosciences;Oligodendroglia;Organism;Outcome;Parvalbumins;Pathway interactions;Phenotype;Physiology;primary outcome;Proteins;Research;Route;SCN1A protein;secondary outcome;Seizures;single molecule;single-cell RNA sequencing;Somatosensory Cortex;Specificity;Synaptophysin;Technology;Temperature;Testing;TFRC gene;Therapeutic;therapeutic evaluation;Treatment Efficacy;Untranslated RNA;uptake;Wild Type Mouse

PROJECT_TITLE: Neuron-specific modulation of gene expression using systemically administered bispecific antibody-ASO conjugates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-V (91)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Adolescent Sexual Activity;Clinical Research;Contraception/Reproduction;Data Science;Health Services;Maternal Health;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

PHR: This project aims to facilitate rigorous research on state-level sexual and reproductive health (SRH) policies and their health impact by creating, optimizing, and disseminating an open-access data dashboard of state SRH policies spanning from 1973 to 2028 that integrates legal and substantive expertise and optimizes utility for researchers. By providing accurate and accessible longitudinal data, this initiative supports evidence-based policymaking that can improve SRH and maternal-child health outcomes in the United States.

PI_NAMEs: MASLOWSKY, JULIE M (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;Address;Affect;Alaska;Area;Arkansas;Birth;California;child bearing;Child Health;Chlamydia;Code;Contraceptive Agents;Contraceptive methods;cost;court;dashboard;Data;data access;Data Analyses;data dashboard;Data Files;Data Science;Data Sources;design;Desire for food;District of Columbia;empowerment;Equilibrium;evidence base;experience;Feedback;Female;Future;Geography;Goals;Health;health organization;Health Policy;Health Sciences;Housing;human centered design;improved;innovation;insight;Intuition;Laws;Lawyers;Legal;longitudinal analysis;longitudinal database;Maternal and Child Health;Maternal Mortality;Methodology;Methods;New Hampshire;Outcome;outreach;Pathway interactions;Patient Rights;Pattern;peer;Peer Review;Policies;Policy Analysis;Policy Making;Pregnancy;Process;Production;Provider;Public Health;Publishing;Recording of previous events;Regulation;Reproductive Health;Research;Research Personnel;Rights;Role;Sex Education;sexual and reproductive health;Sexually Transmitted Diseases;Shapes;social media;Social Sciences;Source;Techniques;Teenagers;Time;United States;usability;user-friendly;Variant;Vermont;Visualization;webinar;Women's Health

PROJECT_TITLE: Creating a state-level policy data dashboard to facilitate research on reproductive health

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: CA

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Prevention;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Better model systems are needed to study the impact of senescence and the senescence associated secretory phenotype (SASP) on early tumor formation in vivo. We hypothesize that irradiation or chemical insult of the mammary gland induces senescence, which can then drive the outgrowth of preneoplastic cells into tumors. We plan to test this model system by targeting senescent cells with senolytic agents, followed by studies targeting specific SASP factors, to gain insight into the mechanisms by which senescence drives early tumorigenesis.

PI_NAMEs: KORKOLA, JAMES  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Aging;animal old age;Animals;Antibodies;Apoptotic;arm;Automobile Driving;Biological Models;Breast Cancer Model;Breast Cancer Prevention;Breast Epithelial Cells;breast tumorigenesis;Cancerous;candidate identification;Carcinogens;cell growth;cell injury;Cell Survival;Cells;Chemicals;Chronic;D Cells;Data;differential expression;Early Diagnosis;enhancing factor;Estrogen receptor positive;Excision;Fatty acid glycerol esters;Fibroblasts;Genes;Gland;Goals;Growth;Histology;Human;Immune;Immune system;Immune System Diseases;Immunocompetent;Immunofluorescence Immunologic;Impairment;Implant;implantation;In Vitro;in vivo;in vivo Model;Inbred BALB C Mice;Incidence;Inflammatory;inhibitor;insight;irradiation;juvenile animal;Lesion;Link;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary gland;Mammary Neoplasms;Mammary Tumorigenesis;Measures;Mesenchymal;Modeling;mouse model;Mus;Mutation;neoplastic;novel;Oncogenic;Pharmaceutical Preparations;Physiological;preneoplastic cell;prevent;Prevention approach;Proliferating;receptor;Reporting;response;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;small molecule inhibitor;Stress;Study models;System;Testing;Therapeutic;Tissues;transcriptome sequencing;transplant model;Transplantation;tumor;Tumor Cell Line;Tumor Promotion;Tumor Subtype;tumorigenesis;tumorigenic;Up-Regulation

PROJECT_TITLE: Targeting Senescence and the senescent secretome to impact breast cancer formation

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (M1)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Neurosciences;Sexually Transmitted Infections

ORG_CITY: PRINCESS ANNE

ORG_NAME: UNIVERSITY OF MARYLAND EASTERN SHORE

ORG_STATE: MD

PHR: Narrative: In our laboratory, we found that herpes virus infection in neuronal cells was controlled in part by thyroid hormone. This discovery may be critical in understanding viral reactivation. We propose specific experiments to investigate the detailed mechanisms using different models, and the results from the studies will benefit our knowledge and contribute to the development of therapeutic agents.

PI_NAMEs: HSIA, SHAOCHUNG VICTOR (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Academy;Accreditation;acute infection;Afferent Neurons;Animal Model;Animals;antagonist;Automobile Driving;Award;Binding;Biotechnology;Brain;BRAIN initiative;Cell Line;Cells;Chronic;Clinical;Collaborations;Computers;Crystallography;cytokine;Data;delivery vehicle;density;Dependovirus;design;Disease;Doctor's Degree;Dominant-Negative Mutation;Drug Targeting;Economics;Education;Educational Curriculum;Educational workshop;Elements;Encephalitis;epidemiologic data;epigenetic regulation;Esthesia;Exhibits;experimental study;Frequencies;Gene Delivery;Gene Expression;Genes;Genetic Transcription;Genome;Goals;Graduate Education;Growth Factor;Health;Herpes zoster disease;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;High School Student;Hormonal;Hormone Receptor;hormone regulation;Hour;Human;Infection;innovation;interest;Knowledge;Laboratories;Lead;Learning;Life Cycle Stages;Ligands;manufacture;MAP Kinase Gene;Mediating;Mentorship;Methimazole;Methods;Microscopy;Mission;Modeling;Molecular Profiling;Monitor;Mus;Mutagenesis;Mutation;Neuroglia;neuronal excitability;Neurons;Neuropathy;novel;Nuclear Receptors;Nucleotides;Occupations;orofacial;overexpression;Patients;Point Mutation;Production;programs;promoter;Propylthiouracil;prospective;protein data bank;Proteomics;Publications;reactivation from latency;receptor binding;Regulation;Repression;Research;Science;science education;Secure;Series;Signal Pathway;Signal Transduction;skills;Sodium Channel;Spinal Ganglia;STEM research;Structure;Students;Testing;therapeutic development;Thyroid Gland;Thyroid Hormone Receptor;Thyroid Hormones;Thyroxine;Time;tool;trafficking;transcriptomics;underrepresented minority student;United States National Institutes of Health;Universities;university student;Untranslated RNA;Up-Regulation;vector;Viral;Viral Genes;viral RNA;virology;Virus;Virus Diseases;Virus Latency;Virus Replication;voltage

PROJECT_TITLE: Hormonal Regulation of HSV-1 Replication in Neurons

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-G (56)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse;Tobacco

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Opioid abuse is a massive public health crisis; maintenance therapies can help wean people off opioids but additional therapeutic approaches are much needed. Here we propose to evaluate the effects of opioids on an overlooked neural circuit that plays a known role in nicotine dependence but that also expresses high levels of the receptor that opioids act on. This work will provide new information on how opioids induce dependence and new avenues for preventing or treating opioid use disorder.

PI_NAMEs: HNASKO, THOMAS  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Acetylcholine;Acute;Affective;Affective Symptoms;Anxiety;anxiety-related behavior;associated symptom;Automobile Driving;Axon;Behavior;behavior change;Behavioral;Cell Nucleus;cell type;Cells;Chronic;Complement;CRISPR/Cas technology;Data;Dependence;dysphoria;Electrophysiology (science);Enkephalins;excitatory neuron;experimental study;Fiber;Fright;Glutamates;Habenula;Heterogeneity;in vivo;inhibitory neuron;interpeduncular nucleus;Lateral;Link;Literature;Maintenance Therapy;Medial;Mediating;Molecular;mu opioid receptors;Mus;neural circuit;Neural Inhibition;neurochemistry;Neurokinin B;neuronal cell body;Neurons;Neuropeptides;Neurotransmitters;Nicotine;Nicotine Dependence;Nicotine Withdrawal;novel therapeutic intervention;Opiate Addiction;Opioid;opioid abuse;Opioid Receptor;opioid use disorder;opioid withdrawal;Pattern;Persons;Photometry;Physiological;Play;Population;postsynaptic;presynaptic;prevent;Public Health;Receptor Activation;receptor expression;Receptor Signaling;Relapse;Research;response;Role;Side;Signal Induction;Slice;Structure;Substance P;Synapses;Synaptic Transmission;Testing;Therapeutic;transmission process;Viral;Weaning;Withdrawal;Work

PROJECT_TITLE: Opioid actions on the habenulo-peduncular circuit

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The National Cancer Clinical Trials Network (NCTN)-led clinical trials have transformed the landscape of the frontline management of patients with chronic lymphocytic leukemia (CLL) in the past decade. With an increased understanding of the role of measurable residual disease (MRD) in the contemporary management of CLL, the next generation of NCTN-led clinical trials will use MRD to guide the optimal duration and intensity of therapy. This proposal highlights my goals of helping to develop, implement, and complete these state-of- the-art NCTN-led clinical trials that will lead to a paradigm shift in the frontline management of CLL.

PI_NAMEs: PARIKH, SAMEER ASHOK (contact)

PROGRAM_OFFICER_NAME: TAWAB-AMIRI, ABDUL

PROJECT_TERMS: Age Years;American College of Radiology Imaging Network;Award;Biological Markers;cancer clinical trial;career;Chronic Lymphocytic Leukemia;Clinic;Clinical;Clinical Trials;Clinical Trials Network;Collaborations;Comprehensive Cancer Center;Correlative Study;Country;Development;Disease;Eastern Cooperative Oncology Group;Goals;Hematology;human old age (65+);improved;Malignant lymphoid neoplasm;Manuscripts;Measurable;medical schools;Medicine;member;mid-career faculty;National Clinical Trials Network;next generation;novel;older patient;Outcome;participant enrollment;Patient Care;Patients;phase 3 study;Protocols documentation;Publishing;Randomized;Research;Residual Neoplasm;Role;Sampling;Scientist;Small-Cell Lymphoma;Specialist;Strategic Planning;Testing;Work;Writing

PROJECT_TITLE: Paradigm Shift in the Management of Patients with Previously Untreated Chronic Lymphocytic Leukemia through NCI-sponsored Clinical Trials

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (M1)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Public Health Relevancy Statement Aberrant calcium handling by the neuron’s major intracellular calcium store, the endoplasmic reticulum (ER), is associated with a host of neurodegenerative disorders, but it is unclear how ER calcium signaling regulates the function and stability of neurons in vivo. The mechanisms linking ER calcium handling to neuronal function are likely to be deeply conversed. By investigating the role of the ER in neuronal calcium signaling in the context of well-defined neural circuits in a tractable experimental system—the Drosophila visual system—we seek to provide an essential mechanistic framework for understanding how ER calcium uptake and release contribute to brain function in health and disease.

PI_NAMEs: BARNHART, ERIN L (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Affect;Animal Behavior;Biological;Brain;Ca(2+)-Transporting ATPase;Calcium;Calcium Channel;Calcium Signaling;cell type;Cells;connectome;Defect;Dendrites;Detection;Diffusion;Disease;Drosophila genus;Endoplasmic Reticulum;Exhibits;experimental study;Functional disorder;Genetic;Health;Homeostasis;imaging approach;Imaging Techniques;in vivo;in vivo imaging;in vivo imaging system;Individual;Knowledge;Link;mathematical model;Measurement;Measures;Membrane Potentials;Mitochondria;Modeling;Molecular;Motion;neural circuit;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;neuroregulation;neurotransmission;neurotransmitter release;Pattern;Photic Stimulation;Physiological;postsynaptic;Process;Production;Property;Public Health;Reaction;Reporter;response;Role;Second Messenger Systems;Shapes;signal processing;Signal Transduction;Source;spatiotemporal;Stimulus;Synapses;Synaptic plasticity;Synaptic Transmission;Synaptic Vesicles;System;Testing;Time;tool;uptake;Vision;Visual;visual stimulus;Visual System;voltage;Work

PROJECT_TITLE: ER calcium handling, single cell processing, and neural circuit function in vivo

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE  Syphilis is becoming an increasingly urgent public health issue, however, existing methods for the clinical diagnosis of syphilis are lacking with respect to speed, availability, cost, and time to resulting, and are also subject to false testing results under certain circumstances. This proposal outlines the development and validation of an inexpensive, specific, rapid, and ultrasensitive strategy for diagnosing syphilis infections using sensors based on aptamers, which are short single-stranded DNA molecules able to bind target proteins. These technologies will be immediately translatable and practical for clinical diagnostics, and will provide enhanced capabilities in support of rapid, point of care testing for syphilis infections.

PI_NAMEs: SALIPANTE, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: accurate diagnosis;Address;Adult;Affinity;Algorithms;Antibodies;Antibody Affinity;Antigens;aptamer;Bacteria;Binding;Biological Assay;candidate identification;Cell surface;Cells;Characteristics;Clinical;clinical diagnosis;clinical diagnostics;Codon Nucleotides;community setting;Congenital Syphilis;Conserved Sequence;Consumption;cost;Cross Reactions;design;Detection;detection limit;detection method;Development;Diagnosis;Diagnostic;diagnostic assay;Diagnostic Procedure;Disease;DNA-Directed DNA Polymerase;effective therapy;Escherichia coli;Event;Evolution;Fluorescence;follow-up;Genitourinary system;Goals;Head;Healthcare;Human;human microbiota;Hybrids;immunogenic;improved;In Vitro;Incubated;Infection;innovation;instrumentation;Laboratories;Ligands;Measurement;Measures;Medical;Membrane;Methodology;Methods;Modality;Molecular;next generation sequencing;novel;novel diagnostics;Nucleic Acid Amplification Tests;Oligonucleotides;Organism;pathogen;Patients;Performance;Periodicity;point of care;point of care testing;Polymerase;protein purification;Proteins;Protocols documentation;Provider;Public Health;public health emergency;rapid detection;rapid diagnosis;Reaction;Reproducibility;Residual state;response;screening;sensor;Serology test;Signal Transduction;Single-Stranded DNA;Site;Skin;Specificity;Specimen;Speed;success;Syphilis;Syphilis Serodiagnosis;Technology;Test Result;Testing;Time;time use;Transgenes;Transgenic Organisms;Treponema pallidum;United States;Validation;Work

PROJECT_TITLE: Rapid and Ultrasensitive aptamer-based detection technologies for T. pallidum

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 FDS-M (M1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative This project will elucidate how the brain adaptively solves sequential decision-making problems by focusing on three key areas implicated in many high-level cognitive operations, including the prefrontal cortex, basal ganglia, and hippocampus. Proposed experiments will shed new light on the nature of distributed computations in the brain. The results will contribute to improving artificial intelligence and treatment of various psychiatric and neurological disorders, such as schizophrenia.

PI_NAMEs: LEE, DAEYEOL  (contact);MA, WEI JI

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Algorithms;Animals;Arbitration;Area;Artificial Intelligence;Basal Ganglia;Behavior;behavior prediction;Behavioral;Biological;Brain;caudate nucleus;Cognition;Cognitive;Communication;Complex;Computer Models;Corpus striatum structure;Data Analyses;Decision Making;density;Elements;Environment;Evaluation;Event;experience;experimental study;Eye Movements;flexibility;Frequencies;Future;Goals;heuristics;Hippocampus;Human;improved;Individual;Investigation;knowledge of results;Learning;learning strategy;Macaca mulatta;machine learning method;Maps;Mental disorders;Modeling;Monitor;Monkeys;Nature;Nervous System Disorder;neural;Neural Network Simulation;Neurons;neurophysiology;Neurosciences;neurotransmission;nonhuman primate;novel;operation;Organism;Outcome;Pattern;Play;Population;Positioning Attribute;Prefrontal Cortex;Process;prospective;Psychological reinforcement;recurrent neural network;Research Personnel;Rewards;Role;Running;Schizophrenia;Signal Transduction;statistical and machine learning;Structure;Study models;Task Performances;Techniques;Testing;theories;Training;Trees;Update;Variant;Work

PROJECT_TITLE: Neural basis of planning

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative Aging cells show considerable deterioration of nuclear structure, but specific factors or events that cause the deterioration are poorly understood. This study uses the genetic model C. elegans to analyze cellular mechanisms that drive nuclear deterioration. A major focus is the formation and consequences of nuclear fat deposits that accumulate in some cell types during aging, and that have the potential to damage the nuclear envelope.

PI_NAMEs: PRIESS, JAMES R (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Age;age related;Aging;aging mechanism;Apoptosis;Binding Proteins;BSCL2 gene;Caenorhabditis elegans;Cell Aging;cell injury;Cell Nucleus;cell type;Cells;Cellular Stress;Chromosome Structures;Chromosome Territory;Coat Protein Complex I;Complex;Cyst;Cytoplasm;Defect;Deposition;Deterioration;Development;dominant genetic mutation;Endoplasmic Reticulum;Enzymes;Event;Excision;Experimental Models;Fatty acid glycerol esters;forward genetics;Frequencies;Genes;Genetic;Genetic Models;Genetic Screening;Genetic study;Germ Cells;Goals;Health;healthspan;healthy aging;Hepatocyte;Heterochromatin;Human;Institution;Intestines;Investments;Lamin Type A;Lamins;Link;Lipase;Lipid Inclusion;Lipids;Lipoproteins;Liver;Liver diseases;Mediating;Microfilaments;Modeling;Morphology;mutant;Mutation;Nematoda;Nuclear;Nuclear Envelope;Nuclear Inner Membrane;Nuclear Lamina;Nuclear Structure;Nucleoplasm;older adult;Organism;Pathway interactions;Peripheral;prevent;Privatization;Proteins;Reproduction;reproductive development;Research;Retrieval;reverse genetics;Role;stem cell population;stem cells;System;Testing;Tissues;tool;Vacuole;Work

PROJECT_TITLE: Tissue Mechanisms of Aging in the Genetic Model C. elegans

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The goal of these studies is to understand how sensory nerves in the skin regulate immune cell function during skin penetration by parasitic worms found in contaminated water. We think that protective immunity against these worms may be dependent on interactions between itch-specific nerves and immune cells in the skin, but this has not been studied before. The proposed experiments may uncover a therapeutic means to prevent skin penetration, which does not currently exist.

PI_NAMEs: HERBERT, DE'BROSKI R (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: acquired immunity;afferent nerve;Afferent Neurons;Anti-Inflammatory Agents;Antigen-Presenting Cells;arginase;Automobile Driving;Bacteria;Binding;Calcitonin;Calcitonin Gene-Related Peptide;Calcitonin-Gene Related Peptide Receptor;Cations;Cell Communication;Cell Physiology;Cells;Chemicals;Chromatin;contaminated water;Curiosities;Cutaneous;cytokine;Data;Dendritic Cells;design;Diphtheria Toxin;Environment;experience;experimental study;Failure;Fibroblasts;Genetic;genomic locus;Goals;GTP-Binding Proteins;helminth infection;Helminths;Host resistance;Human;IL17 gene;Immune;Immune response;Immunity;immunoregulation;Impairment;Individual;Infection;Inflammatory;insight;Interleukins;Ion Channel;ITGAX gene;Larva;Link;Macrophage;Mediating;Mediator;Membrane;monocyte;Mus;Myelogenous;Myeloid Cells;Natural Immunity;Nerve;Neuroimmunomodulation;Neurons;Neuropeptides;Nuclear Protein;Nuclear Translocation;optogenetics;parasite invasion;Parasite resistance;pathogen;Penetration;Peptide Signal Sequences;Perception;Persons;Phenocopy;Population;Population Heterogeneity;Predisposition;prevent;Preventive measure;Primary Infection;Production;protective factors;Proteins;Pruritus;receptor;receptor-activity-modifying protein;recruit;Resistance;response;Rodent Model;Role;Schistosoma;Schistosoma mansoni;Schistosomatidae;secondary infection;Sensory;Shapes;Signal Transduction;Signaling Molecule;Skin;Skin Tissue;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Tissues;TNF gene;TRP channel;TRPV channel;TRPV1 gene;waterborne;Wild Type Mouse;Yeasts

PROJECT_TITLE: Neuro-Immune mechanisms against skin-penetrating helminths

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (09)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Influenza;Pediatric;Pneumonia and Influenza;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Vaccine Related

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: This study will examine the impact of school-located vaccination (SLV) on routine, influenza, and COVID-19 vaccination rates among school-aged children and adolescents in Colorado from 2018-2024, overall and among health disparity populations. We will use propensity score matching in extended Cox models to assess the causal impact of three SLV models: school-based health centers (SBHCs), school- located vaccination clinics (SLVCs) independent of an SBHC, and SLVCs run by an SBHC, on students’ vaccination likelihood; simulate potential local- and state-level impacts of SLVCs on routine, influenza, and COVID-19 vaccine coverage among all students in Colorado and members of health disparity populations; and use the Consolidated Framework for Implementation Research and a modified positive deviance approach to examine contextual factors influencing recent implementation and success of the three models of SLV. Study findings will be immediately actionable for implementers and policymakers in Colorado and across the country as they work to address vaccination inequities exacerbated by the COVID-19 pandemic and prepare for future public health emergencies.

PI_NAMEs: FAHERTY, LAURA JOHNSON;GROMIS, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Adolescent;Area;Black race;Characteristics;Child;Childhood;Clinic;Colorado;Communities;Consolidated Framework for Implementation Research;contextual factors;cost;Country;COVID-19;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;Cox Models;Data;Databases;Disparity;economic disparity;ethnic minority;Ethnic Population;Event;Exclusion;experience;Face;Family member;Funding;Future;Health;health care settings;health disparity populations;health equity;Health system;high risk;Hispanic;Hispanic Populations;Hospitalization;Hour;Household;Immunization;Immunization Programs;implementation science;improved;Inequity;Influenza;Influenza A Virus, H1N1 Subtype;Influenza vaccination;influenza virus vaccine;Information Systems;innovation;Insurance Coverage;interest;Investigation;Link;Low income;Medical;member;Methods;minority communities;Misinformation;Modeling;models and simulation;National Institute on Minority Health and Health Disparities;Nature;neighborhood disadvantage;Not Hispanic or Latino;novel;pandemic disease;patient centered medical home;peer;Play;Policy Maker;Population;Primary Care;programs;public health emergency;Quasi-experiment;racial minority;racial minority population;racial population;Reporting;Role;Running;rural area;Rural Community;rural residence;SARS-CoV-2 infection;school based health center;School Nursing;School-Age Population;Schools;seasonal influenza;Services;Socioeconomic Status;Students;success;Time;Transportation;trend;underserved rural area;Uninsured;United States;Vaccination;vaccine acceptance;vaccine delivery;vaccine distribution;Vaccines;Wait Time;Work

PROJECT_TITLE: School-Located Vaccination to Reduce Inequities in Vaccination Uptake Among Historically Excluded Populations in Colorado

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Copy number variants are important genetic risk factors for autism and related neuropsychiatric disorders. This project aims to define neurodevelopmental mechanisms, as well as behavioral abnormalities, associated with 17q12 CNVs, genetic risk factors for autism and other neuropsychiatric disorders. We will also screen small- molecule treatments on relevant cell models with 17q12 CNV mutations.

PI_NAMEs: MORROW, ERIC M (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adult;Agonist;antagonist;Anterior;autism spectrum disorder;Behavior;Behavioral;behavioral study;bench to bedside;Brain;brain abnormalities;Brain Diseases;brain shape;Cations;Cell Line;Cell model;Cells;Clinical Research;Code;Collaborations;combinatorial;Complex;Copy Number Polymorphism;Craniofacial Abnormalities;Defect;Development;Disease;Embryo;Exhibits;experimental study;Family;Foundations;Functional disorder;Gene Deletion;Gene Dosage;Gene Duplication;Genes;Genetic;genetic risk factor;Genetic Transcription;Genetic Variation;Head;Heterogeneity;Hippocampus;Human;human induced pluripotent stem cells;human stem cells;Impairment;In Vitro;in vivo;Inbreeding;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;innovation;International;Knockout Mice;Knowledge;Link;Magnetic Resonance Imaging;Methodology;Molecular;Molecular Analysis;morphometry;mouse genetics;Mouse Strains;multidisciplinary;Mus;Mutation;Neonatal;neural;neurodevelopment;Neurodevelopmental Disorder;neuron development;Neurons;neuropsychiatric disorder;novel;Partner in relationship;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;Phenotype;postnatal;postnatal development;Predisposition;Process;programs;Prosencephalon;Proteins;Reporter;Research;Resources;Risk Factors;Rodent;Severities;small molecule;stem cell model;Testing;Therapeutic;Therapeutic Intervention;Thinness;Transcription Coactivator;transcription factor;transcriptome;transcriptome sequencing;translational approach;treatment response;WNT Signaling Pathway

PROJECT_TITLE: Neurodevelopmental mechanisms in 17q12 CNV disorders and autism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (57)]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE:  There is an unmet need to develop innovative immunomodulatory strategies to overcome immune suppression in glioblastoma. The focus of this work is to validate a new therapeutic strategy for glioblastoma based on a novel macrophage-based immunotherapy approach. SLIT2/ROBO inhibitors from this work will represent promising candidates for future evaluation in preclinical models of glioblastoma.

PI_NAMEs: GABR, MOUSTAFA  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Adjuvant;Adverse event;adverse event risk;Affinity;angiogenesis;assay development;Astrocytes;Binding;Biological Assay;Biological Products;Biological Response Modifier Therapy;Biophysics;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier penetration;Brain Neoplasms;Cell Line;Cells;Central Nervous System;Chemotaxis;chemotherapy;Clinical Trials;Combined Modality Therapy;Complex;cytotoxic;Development;Diffuse;dosage;Drug Kinetics;Effectiveness;Energy Transfer;Environment;Enzyme-Linked Immunosorbent Assay;Evaluation;FDA approved;Fibrin;Fluorescence;Focal and Segmental Glomerulosclerosis;Future;Gel;Gene Expression;Gene Expression Profile;Glioblastoma;Glioma;Goals;high throughput screening;Immune Evasion;immune modulating agents;Immune system;immunogenicity;Immunomodulators;immunomodulatory strategy;immunopharmacology;Immunosuppression;Immunotherapy;immunotherapy clinical trials;improved;In Vitro;inhibitor;innovation;Invaded;Investigation;knock-down;lead optimization;Macrophage;Malignant - descriptor;Microglia;Migration Assay;mouse model;multimodality;Mus;nanomolar;Neoadjuvant Therapy;neoplastic cell;new combination therapies;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;Penetration;Pharmaceutical Chemistry;phase III trial;Pilot Projects;Positioning Attribute;Pre-Clinical Model;preclinical evaluation;Prevention;Primary Brain Neoplasms;Prognosis;Proteins;Radiation therapy;randomized trial;response;Risk;screening;Signal Transduction;small molecule;Small Molecule Chemical Library;small molecule inhibitor;spheroids;success;Supportive care;synergism;T cell response;Temperature;Testing;Therapeutic;therapeutic target;Time;Tissues;tumor;tumor microenvironment;Tumor-associated macrophages;Validation;Work

PROJECT_TITLE: Small molecule inhibitors of Slit2/Robo signaling as novel therapeutics for glioblastoma

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Data Science;Dementia;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative This project aims to advance explainable AI (XAI) to better understand Alzheimer’s disease (AD) by bridging the gap between complex machine learning models and biological insights. Through the development of innovative XAI methods, the project seeks to generate biologically informed explanations of AD progression and identify potential AD drivers, ultimately contributing to our understanding of AD and the discovery of therapeutic targets.

PI_NAMEs: LEE, SU-IN  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Acceleration;Address;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease therapeutic;Amyloid beta-Protein;Area;Biological;Biomedical Research;cell type;Cells;cellular pathology;cohort;Complex;Computer Models;Data;Data Analyses;Data Set;deep neural network;Development;Dimensions;Disease;Disease Progression;Early identification;effective therapy;Electronic Medical Records and Genomics Network;Ensure;Event;experimental study;explainable artificial intelligence;Face;Failure;Gene Expression;Genes;Genetic study;graph neural network;Human;human induced pluripotent stem cells;immune clearance;immune function;improved;Individual;innovation;insight;Intervention;Investigation;knock-down;Knowledge;knowledge graph;knowledge integration;Learning;Literature;machine learning model;mathematical theory;Measures;Methods;Microglia;Modeling;Modernization;multimodality;Multiomic Data;Nature;network dysfunction;Neurofibrillary Tangles;Neuroglia;Neuronal Differentiation;Neurons;Oral;Output;overexpression;Pathogenesis;Pathology;Pathway interactions;Pattern;Phagocytosis;Pharmaceutical Preparations;Phenotype;Play;Proteins;Research Personnel;response;Role;Sampling;small hairpin RNA;Specificity;success;supervised learning;Synapses;synaptic function;Synaptic Transmission;System;tau Proteins;tau-1;Techniques;Technology;Text;theories;therapeutic target;trafficking;Translating;translational model;Translations;Trees

PROJECT_TITLE: IDEAL-XAI: Advancing Explainable AI to Identify Early Driver Events of Alzheimer's Disease

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Mental Health;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Alcohol Use Disorder (AUD) is characterized by attenuated capacity to recognize and interpret the emotional states of others. Despite the relevance of interpersonal function to AUD treatment and recovery, fundamental questions regarding social cognition during treatment and early abstinence remain unaddressed. The proposed project will characterize change in emotion processing, identify cognitive and affective mechanisms driving such change, and evaluate the causal contribution of disrupted emotion processing to critical treatment outcomes (e.g., treatment dropout, relapse).

PI_NAMEs: LEWIS, BEN  (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Abstinence;Accounting;Address;Affect;Affective;alcohol use disorder;Alcohols;Alexithymias;Attenuated;Automobile Driving;clinically relevant;Cognitive;cognitive capacity;cognitive change;cognitive function;cognitive process;cognitive task;cognitive training;Collection;Communities;computerized;critical period;Cross-Sectional Studies;Data;Data Collection;Development;Dropout;emotion regulation;Emotional;Emotions;executive function;experience;Failure;Growth;high intensity drinking;hospital readmission;improved;indexing;Individual;Interpersonal Relations;Intervention;intervention delivery;Interview;Investigation;Laboratories;Measures;Mediating;Mediator;Modality;Modeling;Moods;multimodality;neurobehavioral;novel;Outcome;Patients;Performance;premature;Process;Quality of life;Recovery;recruit;Relapse;Reporting;Residential Treatment;Risk;Sampling;Self Efficacy;social;social cognition;Social Functioning;social situation;Social support;Statistical Models;Stimulus;Testing;Therapeutic;therapy design;therapy development;Training;Translating;treatment adherence;Treatment Efficacy;Treatment outcome

PROJECT_TITLE: Social cognition in AUD recovery: Understanding trajectories, consequences, and mechanisms of change for deficits in emotion processing

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Aging;Arthritis;Back Pain;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Depression;Fibromyalgia;Health Services;Mental Health;Mental Illness;Neurosciences;Pain Research;Prevention;Primary Health Care;Rehabilitation;Telehealth

ORG_NAME: BUTLER HOSPITAL (PROVIDENCE, RI)

PHR: NARRATIVE The proposed work is expected to result in the development of a brief, peer-led video intervention that will utilize innovative narrative communication strategies to deliver evidence-based principles for self-management of chronic musculoskeletal pain to older adults in order to expand treatment uptake and reach. Such results are expected to have an important positive impact on patient functioning that will move us closer to the long-term goal of widespread dissemination of evidence-based interventions for those with chronic pain conditions.

PI_NAMEs: GAUDIANO, BRANDON A;UEBELACKER, LISA A (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: acceptability and feasibility;Adult;Anxiety;arthritic pain;Back Pain;Behavior;behavior change;Behavior Therapy;Behavioral;Benchmarking;Bibliotherapy;bone;Books;Certification;Cessation of life;Chronic;chronic musculoskeletal pain;chronic pain;chronic pain management;chronic painful condition;Clinical Practice Guideline;Clip;Code;Cognitive Therapy;combat;Communication;Community Health Aides;comparison intervention;Consumption;coping;Coping Skills;cost;Data;Degenerative polyarthritis;Depressed mood;design;Development;digital;digital health;digital intervention;Education;Educational process of instructing;Effectiveness;effectiveness trial;Emotional;evidence base;Evidence based intervention;Evidence based treatment;experience;Family member;Fibromyalgia;Friends;Funding;Future;Goals;Grant;Health;Health education;Health Personnel;Health Professional;Hearing problem;Helping to End Addiction Long-term;Hybrids;Hypertension;Impairment;improved;Individual;innovation;internalized stigma;Intervention;Interview;Joints;Learning;Life;Mediator;medical specialties;Mental Depression;Mental Health;Methods;mindfulness;Modeling;Motivation;Muscle;Musculoskeletal Pain;news;older adult;opioid epidemic;Outcome;Overdose;Pain;Pain interference;Participant;Patients;peer;peer support;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Population;Primary Care;primary care patient;primary care provider;Psychiatric Hospitals;psychologic;Psychotherapy;Public Health;Quality of life;Randomized;Recommendation;Recording of previous events;Recovery;Reporting;Research;self help;Self Management;Series;social;soft tissue;Specialist;Speed;Spine pain;Stream;Substance Use Disorder;Suicide;Suicide prevention;Technology;telehealth;Testing;Therapeutic;therapy design;therapy development;Time;Training;treatment strategy;uptake;Video Recording;Vision;Visit;Vocation;web site;Work

PROJECT_TITLE: Development and preliminary testing of a peer narrative video intervention for older adults with chronic pain

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proposed investigation is relevant to public health because it focuses on establishing the efficacy of an accessible telehealth exercise intervention specifically for rural cancer survivors experiencing cancer-related fatigue. Novel methods of remotely assessing objective physical function and performing state-of-the-art metabolomic analyses are utilized to investigate exercise-associated mechanisms of cancer-related fatigue remediation first in an underserved population that stands to benefit from subsequent innovations in exercise prescription due to existing health disparities. Thus, the proposed research is relevant to the interest of the NCI Division of Cancer Control and Population Sciences in reducing the burden of cancer through improved survivorship.

PI_NAMEs: MARKER, RYAN J (contact)

PROGRAM_OFFICER_NAME: SAMIMI, GOLI

PROJECT_TERMS: access disparities;Athletic;Biological Markers;Blood;Breast;Breast Cancer survivor;Cancer Burden;Cancer Center;Cancer Intervention;cancer risk;Cancer Survivor;Clinical;Clinical Trials;Colorado;Control Groups;curative treatments;Decentralization;Development;Division of Cancer Control and Population Sciences;Dryness;effectiveness testing;efficacy clinical trial;Exercise;exercise intervention;exercise prescription;exercise program;experience;Fatigue;fatty acid oxidation;Foundations;Future;future implementation;geographic disparity;Geography;Goals;Guidelines;health disparity;Health Services Accessibility;Health Technology;Impairment;improved;Individual;Infrastructure;innovation;interest;Intervention;Investigation;Knowledge;Laboratories;Malignant Neoplasms;Measurement;Measures;metabolic profile;metabolomics;Methodology;Methods;Monitor;Montana;multi-site trial;novel;Oncology;Outcome;patient population;Physical Function;pilot test;poor health outcome;Population;Prevalence;primary outcome;programs;prostate cancer survivors;Public Health;Randomized, Controlled Trials;recruit;remediation;remote assessment;Reporting;Research;response;Risk;Rural;Rural Population;rural underserved;Sampling;scale up;Services;Spottings;standard of care;Subgroup;Survivors;survivorship;Symptoms;telehealth;therapy design;Travel;Underserved Population;Universities;Waiting Lists;Work

PROJECT_TITLE: Effects of a telehealth exercise program for rural cancer survivors with cancer-related fatigue including integrated longitudinal assessments of objective physical function and fatty acid oxidation

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Bipolar Disorder;Brain Disorders;Clinical Research;Data Science;Depression;Genetics;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Serious Mental Illness;Social Determinants of Health

ORG_CITY: BROOKLYN

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: The mission of the PsycheMERGE Network is to advance equitable precision psychiatry in learning healthcare system frameworks across the United States. During the course of this project, an interdisciplinary team of investigators at twelve academic medical centers will bring together clinical data (>29 million individuals), genetic data (>1.9 million), and an extraordinary range of scientific expertise (psychiatry, medical informatics, machine learning, statistics, genetics, sociomedical sciences, decision sciences, and ethics) to advance this mission. We will leverage this expertise and data to build on our prior success and address barriers to scalability, utility of genomic data, clinical application, and translation to clinical practice.

PI_NAMEs: PETERSON, ROSEANN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Academic Medical Centers;acceptability and feasibility;Acute;Address;algorithm training;Algorithms;anti-depressive agents;Artificial Intelligence;artificial intelligence method;Attitude;Awareness;Basic Science;Big Data;biobank;Biology;Biomedical Research;Bipolar Disorder;Bipolar I;causal variant;Clinical;clinical application;Clinical Data;clinical decision support;clinical practice;Communities;Country;Data;data privacy;depressive symptoms;Development;Diagnosis;Diagnostic;Differential Diagnosis;disability;Disease;Early Diagnosis;Early treatment;effective therapy;Effectiveness;Environment;Equity;Ethics;experience;federated learning;Funding;Genes;Genetic;genetic analysis;genetic association;genome wide association study;genome-wide;genomic data;Genomics;Goals;Grant;Health system;Healthcare Systems;improved;Individual;individual variation;Infrastructure;innovation;Label;large scale data;Learning;Left;Life Style;Machine Learning;machine learning algorithm;Maps;Medical;Medical Informatics;Medical Records;member;Mental disorders;Methods;Midwestern United States;Mission;Modeling;Mood Disorders;Morbidity - disease rate;mortality;National Institute of Mental Health;network models;novel;Outcome;Patients;Pattern;Performance;Phenotype;Population;precision medicine;predicting response;Prediction of Response to Therapy;Prevention;privacy preservation;Process;Psychiatric Diagnosis;Psychiatry;Records;Research Personnel;response;risk prediction;Sampling;Science;Scientist;Site;social health determinants;Standardization;statistics;Strategic Planning;success;support tools;Testing;Time;tool;Training;transfer learning;Translational Research;Translations;treatment response;United States;Update;Validation;Vision;Work

PROJECT_TITLE: 3/7-PsycheMERGE: Advancing Precision Psychiatry

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-D (65)]


FUNDING_MECHANISM: RESEARCH CENTERS

PHR: NARRATIVE This proposal is being submitted in response to PA-23-189 to support minority graduate student Anastasia Abello. She is conducting work closely related to Dr. Xiao-Jing Wang’s project 2 of the CO HNC SPORE CA261605 Immunotherapy has a limited response rate in the treatment of recurrent and metastatic oral cancer. This research aims to determine how unhealthy diet, which often induces obesity, affects the oral microbiome, thereby influencing cancer progression and immunotherapy response. The findings from these studies will contribute to the enhancement of treatment response.

PI_NAMEs: JIMENO, ANTONIO  (contact);WANG, XIAO-JING

PROGRAM_OFFICER_NAME: HUBBARD, LEAH

PROJECT_TERMS: Address;Affect;Bacteria;cancer immunotherapeutics;cancer immunotherapy;candidate marker;Clinical;Colorado;Diet;dietary;Environmental Risk Factor;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Human;Human Microbiome;Immune checkpoint inhibitor;Immunotherapeutic agent;Immunotherapy;Impairment;improved;insight;Link;malignant mouth neoplasm;Malignant Neoplasms;Metabolic;Metastatic/Recurrent;microbial;microbiome;microbiome alteration;Minority Graduate Student;Modeling;Morbidity - disease rate;mortality;mouse model;multiple omics;Mus;neoplastic cell;Obesity;oral microbiome;Patients;pre-clinical;predictive marker;Quality of life;Reproduction spores;Research;response;Role;Sampling;Specimen;Techniques;Therapeutic;Treatment outcome;treatment response;tumor;tumor growth;tumor progression;Unhealthy Diet;western diet;Work

PROJECT_TITLE: Colorado Head and Neck Cancer SPORE


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Obesity;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Persons of African Ancestry (PAA) are at the epicenter of the obesity and AD epidemics; this higher risk may begin in middle-age. We propose to extend our current Tobago Brain Study to measure circulating levels of AD in middle-aged men and women, and assess the influence of adipo-myokines and cardiometabolic conditions. Our results may advance our understanding of the biological determinants of adiposity-related AD in a high-risk population.

PI_NAMEs: MILJKOVIC, IVA  (contact);ROSANO, CATERINA

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Administrative Supplement;Adult;African ancestry;African Women;Age;aged;aging population;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Biological;Biological Markers;Blood;Brain;Brain-Derived Neurotrophic Factor;Cardiometabolic Disease;cardiometabolism;Cognition;cohort;cytokine;Diabetes Mellitus;Disparity;Epidemic;Exposure to;Goals;Grant;Hematological Disease;high risk;high risk population;human old age (65+);Hypertension;Inflammatory;Infrastructure;Interleukin-6;Intervention;Investments;Leptin;Measures;men;middle age;Midlife women;Obesity;older women;Parents;Persons;Physical activity;protective effect;recruit;Recruitment Activity;Research;Resources;Risk Factors;Sampling;sex;Sex Differences;success;Time;Tobago;Universities;Woman

PROJECT_TITLE: Myosteatosis, Cognition, and Blood Biomarkers of Alzheimer's Disease in Persons of African Ancestry


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Our preliminary results show that heterochronic mutations that cause precocious neuronal differentiation result in early-onset neurodegeneration. This proposal describes a comprehensive and multifaceted set of experiments aimed at understanding the relationship between the timing of neuronal differentiation and the timing of neurodegeneration. The ability to focus on mechanisms and control of neurodegeneration in a single neuron type (nociceptive neurons) in vivo, and to readily employ complementary experimental approaches, will allow us to describe the process at a resolution that is not readily attainable in other systems.

PI_NAMEs: CHANG, CHIEH  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Adult;age related neurodegeneration;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Amyotrophic Lateral Sclerosis;Animals;Autophagocytosis;Biological Models;Brain;Caenorhabditis elegans;Cell Differentiation process;Cell division;cell type;Clustered Regularly Interspaced Short Palindromic Repeats;Congenital Hydrocephalus;Dendrites;Deterioration;Development;early onset;effective therapy;Engineering;Exhibits;experimental study;Future;Genes;genetic manipulation;Genetic Models;genetic variant;Homologous Gene;Human;human model;Huntington Disease;in vivo;insight;Knock-in;loss of function;MicroRNAs;Microtubules;misfolded protein;mitochondrial dysfunction;Mus;mutant;Mutation;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neuronal Differentiation;Neurons;new therapeutic target;Nociceptors;novel;Oxidative Stress;Parkinson Disease;Pathogenesis;Pathologic;Phosphoric Monoester Hydrolases;Positioning Attribute;premature;prevent;Process;Reporting;Resolution;Schedule;Structure;System;tau Proteins;tau-1;Testing;Tissues;Up-Regulation;young adult

PROJECT_TITLE: Understanding the relationship between precocious neuronal differentiation and early-onset neurodegeneration

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Millisecond timescale sensorimotor feedback control of the tongue is necessary for eating, drinking, speaking, and maintenance of airway patency, and aspiration pneumonia due to dysphagia is a leading cause of death in neurological disease. Combining high speed tongue videography and deep learning based image segmentation, we track tongue kinematics with high precision and find that when mice lick at a spout they use information about unexpected misses and touches to rapidly (<50 milliseconds) re-steer their tongue - revealing important online control processes previously studied in primate reaching. To test for general control principles and to determine how cortex, cerebellum, basal ganglia and brainstem control the tongue, we combine recording and manipulation in head-fixed mice engaged in carefully designed lick tasks requiring rapid sensorimotor feedback control.

PI_NAMEs: GOLDBERG, JESSE HEYMANN (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: 3-Dimensional;Afferent Pathways;Apple;Aspiration Pneumonia;Basal Ganglia;Behavioral Paradigm;Brain region;Brain Stem;Cause of Death;Cerebellum;Coffee;Corpus striatum structure;Data;deep learning;Deglutition;Deglutition Disorders;design;dexterity;Dissection;Dissociation;Distant;drinking;Eating;Event;experimental study;Eye;Feedback;Fingers;Food;Goals;grasp;Hand;hand grasp;Head;high throughput screening;imaging Segmentation;Impairment;innovation;Jaw;kinematics;Lateral;Lead;Left;Legal patent;Limb structure;Link;Location;Logic;Maintenance;Maps;Measures;microstimulation;Midbrain structure;millisecond;Motivation;Motor;motor control;Motor Cortex;Movement;Mus;Nervous System Disorder;neural;neuromechanism;Neurons;Nucleus fastigii;Optics;optogenetics;orofacial;Parkinson Disease;Pathway interactions;photoactivation;Population;Population Dynamics;Primates;Process;Pruritus;Rana;Reaction;receptive field;Research;Resolution;response;Role;Saccades;sensorimotor control mechanism;Sensory;sensory cortex;sensory feedback;Shapes;Side;Signal Transduction;Silicon;Site;spatiotemporal;Speech;Speed;Spinal;superior colliculus Corpora quadrigemina;Surface;Synapses;System;Tactile;Testing;Tongue;tool;Touch sensation;Trigeminal System;Update;Viral;Visual;visual map;Water;Work

PROJECT_TITLE: Neural Mechanisms of miss- and touch-guided sensorimotor corrections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-D (55)]


NIH_SPENDING_CATS: Contraception/Reproduction;Prevention

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE Our studies are directly relevant to the missions of the Contraception Research Branch (CRB) of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to develop “new and improved methods of contraception, including non-hormonal methods that do not disturb the hypothalamic- pituitary-gonadal axis.” To respond to the NICHD Strategic Plan 2020 and the mission of the CRB, our R01 proposal will develop novel non-hormonal male contraceptives that inhibit serine/threonine kinase 33, a genetically validated, chemically validated, and testis-enriched contraceptive target.

PI_NAMEs: MATZUK, MARTIN M. (contact)

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: Adult;Affinity;analog;Andrology;Applications Grants;Biochemical;Biology;Birds;Breeding;Callithrix;Callithrix jacchus jacchus;Cartoons;Cellular Assay;Chemicals;Chemistry;Chordata;college;Contraceptive Agents;Contraceptive methods;contraceptive target;Darkness;Digit structure;DNA;drug candidate;drug discovery;Drug Industry;Drug Kinetics;drug metabolism;Drug or chemical Tissue Distribution;Drug Targeting;Family;FDA approved;Female;Fertility;Fishes;Foundations;Frameshift Mutation;Genes;Human;hypothalamic pituitary gonadal axis;improved;in vivo;Infertility;inhibitor;inhibitor therapy;Investigational New Drug Application;kinase inhibitor;Knock-out;Knockout Mice;Lead;lead optimization;Libraries;male;Male Contraceptive Agents;Male Sterility;Mammals;Medical;Medicine;men;Metabolic;Methods;Mission;Mole the mammal;Molecular Structure;Mus;Mutation;nanomolar;National Institute of Child Health and Human Development;nonhuman primate;novel;Peripheral;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Phenocopy;Phosphotransferases;Physiology;Preclinical Drug Development;Property;Protein-Serine-Threonine Kinases;pup;Recovery;reproductive;Reproductive Biology;Reproductive Medicine;Reptiles;Research;reversible contraceptive;Risk;Safety;Secondary to;Serine;sperm cell;Spermatids;Spermatocytes;Strategic Planning;structural biology;Technology;Testis;Therapeutic;tool;Toxic effect;Work;X-Ray Crystallography

PROJECT_TITLE: Reversible male contraception by inhibition of serine/threonine kinase 33

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Bioengineering;Cancer;Digestive Diseases;Kidney Disease;Neuroblastoma;Neurosciences;Orphan Drug;Pancreatic Cancer;Pediatric;Pediatric Cancer;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: NARRATIVE (PUBLIC HEALTH RELEVANCE) The incidence of neuroendocrine tumors has increased nearly 10-fold over the last four decades, and neuroblastoma is the embryonal neuroendocrine tumor accounting for 15% of pediatric cancer-related deaths resulting in a significant public health burden. Alpha-emitter radioligand therapy (α-RLT) is an exciting emerging treatment resulting in enhanced tumor responses (up to 80%) and even complete responses in some patients. Understanding how α-RLT dosing can be optimized with novel diagnostic and nephroprotective therapies to increase tumor response and reduce long-term kidney damage is expected to provide essential data needed for future clinical trial design.

PI_NAMEs: ZEPEDA-OROZCO, DIANA  (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: absorption;Accounting;Acute;Address;Amino Acids;Biochemical;Biological Markers;Blood Urea Nitrogen;Breast;Cessation of life;Chronic;Chronic Kidney Failure;Cisplatin;Clinical Research;Clinical Trials Design;Creatinine;Data;detection limit;Development;diagnostic tool;Disease Progression;DNA Damage;DNA Repair;Dose;Dose Fractionation;dosimetry;ds-DNA;Early Diagnosis;Epidermal Growth Factor;External Beam Radiation Therapy;Fibrosis;Future;Hour;Hydrogen Peroxide;improved;In complete remission;in vivo;Incidence;Inflammation;Injury;injury and repair;Injury to Kidney;innovation;ionization;Islet Cell Tumor;Kidney;Knowledge;LCN2 gene;Linear Energy Transfer;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Melanoma;Methodology;Methods;mimetics;Mitochondria;Modeling;Mus;nephrotoxicity;Neuroblastoma;Neuroendocrine Tumors;Neurosecretory Systems;Non-Invasive Detection;Normal Cell;novel;novel diagnostics;Organic Anion Transporters;Oxidases;oxidative damage;Oxidative Stress;Patients;Pre-Clinical Model;preclinical study;predictive marker;Production;Progression-Free Survivals;Prostate;Public Health;public health relevance;Radiation;radioligand;Radiopharmaceuticals;Reactive Oxygen Species;receptor;Regimen;renal damage;Renal function;repaired;Reporter;Research;response;Role;Scheme;Serum;Somatostatin;Superoxide Dismutase;Superoxides;Testing;theranostics;Therapeutic;therapeutic target;tool;Tubular formation;tumor;Up-Regulation;Urine

PROJECT_TITLE: Optimizing Theranostic Dosimetry and Kidney Biomarkers for Alpha-Emitter Radioligand Therapy in Neuroendocrine Tumors

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Infectious Diseases;Nanotechnology;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: PROJECT NARRATIVE Bacteria that cause ocular infections are becoming increasingly resistant to antimicrobials used in ophthalmology, leading to recalcitrance to cure and treatment failure that can result in serious morbid consequences such as blindness and loss of the eye. This proposal will combine the latest developments in DNA sequencing, microbial enrichment methods and bioinformatics to develop a precision diagnostic tool able to identify the causative agent of the infection and predict antimicrobial agents to which the organism is resistant in a timely and sensitive manner, supporting the use of targeted and effective therapies at early stages of the disease. This work will ultimately provide an innovative diagnostic test extensively optimized for clinical application that has the potential to significantly advance clinical management and help improve the care of patients suffering from sight-threatening infections.

PI_NAMEs: BISPO, PAULO J. M. (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acanthamoeba;accurate diagnosis;Adopted;anti-microbial drug;Antibiotic Resistance;antimicrobial;Antimicrobial Resistance;Bacteria;Bacterial Genome;bacterial resistance;biobank;Bioinformatics;bioinformatics tool;Biological Assay;Blindness;Characteristics;Clinical;clinical application;Clinical assessments;Clinical Management;clinical predictors;Consumption;Cornea;Data;Data Set;Databases;Detection;Development;Diagnosis;Diagnostic;diagnostic strategy;Diagnostic tests;diagnostic tool;Disease;DNA sequencing;effective therapy;emerging antimicrobial resistance;Endophthalmitis;Etiology;Eye;Eye Infections;fungus;Generations;Genome;genome repository;Goals;Health;Hour;improved;in silico;Infection;innovation;Intervention;Judgment;Keratitis;Laboratory Diagnosis;Lead;Literature;Mainstreaming;metagenome;metagenomic sequencing;Metagenomics;Methods;microbial;microbial genomics;Modeling;Morbidity - disease rate;nanopore;Needles;new technology;novel;Operative Surgical Procedures;Ophthalmology;Organism;pandemic disease;pathogen;Pathogen detection;pathogen genome;Patient Care;Patient-Focused Outcomes;Patients;Performance;personalized diagnostics;Pharmaceutical Preparations;point of care;point-of-care diagnostics;portability;Preparation;prospective;rapid detection;Reporting;repository;Research;research clinical testing;Resistance;resistance mechanism;Resolution;Resources;Sampling;Selection for Treatments;Shotguns;Site;Specimen;targeted treatment;Technology;Testing;Third Generation Sequencing;Time;Toxic effect;Treatment Failure;Update;Validation;Vision;Work

PROJECT_TITLE: Point-of-Care Metagenomics for Rapid Detection of pathogens and Antimicrobial Resistance in Sight-Threatening Ocular Infections

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Immunization;Immunotherapy;Infectious Diseases;Sexually Transmitted Infections;Vaccine Related

PHR: PROJECT NARRATIVE The worldwide burden of HSV infection requires a better understanding of virus-host interactions. We propose to define critical determinants of effective immunity that rapidly eliminates HSV before viral dissemination in the skin and mucosal epithelium. This knowledge is central to developing novel interventions and a successful vaccine.

PI_NAMEs: ZHU, JIA  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: adaptive immunity;Affect;Anatomy;Animal Model;Anti-viral Response;Area;attributable risk;Belief;Biological Markers;Cavia;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cells;Characteristics;chemokine;Chronic;Clinical;Communication;Communities;Containment;CRISPR/Cas technology;Cues;cytokine;Cytoplasmic Granules;Data;Defense Mechanisms;Dermal;design;Development;Disease;Distal;Epidermis;Epithelium;Event;functional outcomes;Future;Gap Junctions;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;genetic signature;genital herpes;Genitalia;Goals;Herpes Simplex Infections;HIV Infections;Human;Human Herpesvirus 2;Image;Imaging technology;Immune;Immune response;Immune signaling;Immunity;Immunofluorescence Immunologic;Immunologic Factors;Immunologics;Immunotherapeutic agent;In Situ;in vivo;Individual;Infection;Inflammation;Interferon Type II;Interferons;Intervention;keratinocyte;Knock-out;Knowledge;laser capture microdissection;Lesion;Life Cycle Stages;Link;Macrophage;Mediating;Mediator;Molecular;Mucous Membrane;multiplexed imaging;neutrophil;novel;Outcome;particle;Pathway interactions;Pattern;Peripheral;Predisposition;Process;Production;programs;Property;reactivation from latency;Reagent;recruit;Recurrence;Recurrent disease;Research;Resistance;response;Role;Sensory Nerve Endings;Shapes;Signal Transduction;Simplexvirus;single-cell RNA sequencing;Site;Site-Directed Mutagenesis;Skin;skin barrier;skin biopsy;Spatial Distribution;Surface;T cell response;T-Cell Activation;T-Lymphocyte;Technology;tissue resident memory T cell;Tissues;transcriptome;transcriptomics;Ulcer;vaccine development;Vaccines;Variant;Viral;Viral Genes;Viral Pathogenesis;Viral Physiology;Virus Diseases;virus host interaction;Virus Replication

PROJECT_TITLE: Cross talk between keratinocytes and skin-resident T-cells influences HSV recurrence

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Despite the availability of symptomatic treatments and surgeries, ~10% of the 70 million patients suffering from glaucoma reach permanent blindness. Trabecular meshwork cell loss is an early event in the development of glaucoma and is accelerated in the case of mutant myocilin. Our proposed studies will identify the mechanisms underlying mutant myocilin cytotoxicity and lay the foundation for new disease modifying glaucoma therapies.

PI_NAMEs: LIEBERMAN, RAQUEL L (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Acceleration;Adolescent;Affect;Alzheimer's Disease;Amyloid;analog;Anterior eyeball segment structure;Apoptosis;Autophagocytosis;autosome;Benign;Bioinformatics;Biological Assay;Biological Models;Blindness;Cell Death;Cell Line;Cell Survival;Cells;Code;Collaborations;Complement;cytotoxic;cytotoxicity;Data;deletion library;Development;Disease;Dominant-Negative Mutation;early onset;Endoplasmic Reticulum;Eukaryota;Event;Experimental Designs;experimental study;Extracellular Matrix;Eye;Eye diseases;Family;FDA approved;Follow-Up Studies;Foundations;Functional disorder;gain of function;Gene Deletion;gene product;Genes;Genetic;Glaucoma;Growth;high throughput screening;Homologous Gene;Human;Huntington Disease;Individual;Inherited;insight;knock-down;Length;Libraries;Link;Literature;Mammalian Cell;Modeling;Molecular;Molecular Chaperones;multicatalytic endopeptidase complex;mutant;Mutation;myocilin;Nature;Necrosis;nerve damage;Neurons;new therapeutic target;olfactomedin;Operative Surgical Procedures;Optic Nerve;Outcome;Outcome Study;Oxidative Stress;Painless;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Physiologic Intraocular Pressure;Preparation;prevent;proteostasis;Research;Retina;Risk Factors;Saccharomyces cerevisiae;screening;Signal Transduction;Small Interfering RNA;small molecule;symptom treatment;Symptoms;Testing;timeline;Tissues;tool;Toxic effect;Trabecular meshwork structure;Work;Yeasts

PROJECT_TITLE: Molecular determinants of cytotoxicity due to mutant myocilin misfolding


NIH_SPENDING_CATS: Autoimmune Disease;Celiac Disease;Clinical Research;Digestive Diseases;Genetics;Human Genome;Microbiome;Nutrition

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative A mechanistic understanding of how the gut microbiota influences the development and progression of Celiac Disease is currently missing. This project aims to dissect the complex metabolic interactions between the microbiota and the host in Celiac Disease. This will help establish causal relationships between the gut microbiota and the disease, paving the way for the development of therapeutic strategies that target the gut microbiota to treat Celiac Disease

PI_NAMEs: ZOMORRODI, ALI R (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;Autoimmune;Biochemical Pathway;Catalogs;Celiac Disease;Cells;Characteristics;Chronic;Clinical;Coculture Techniques;Complex;Computer Models;Consumption;Correlative Study;Cues;Data;design;Development;Diet;dietary;Digestive System Disorders;Disease;Down-Regulation;dysbiosis;Early Intervention;Encapsulated;Environment;Environmental Risk Factor;Epithelial Cells;Epithelium;Exposure to;Genetic Predisposition to Disease;genome-wide;Germ-Free;Gluten;Goals;Grain;gut bacteria;gut dysbiosis;gut homeostasis;gut inflammation;gut microbes;gut microbiota;high risk;Homeostasis;host microbiota;Human;Immune;Immune response;Immunology;in silico;Individual;Inflammation;Ingestion;insight;Interdisciplinary Study;Intestinal Content;intestinal epithelium;Intestines;Knowledge;Link;Macrophage;Measurement;Mediating;Metabolic;Metabolic Pathway;Metabolism;metagenome;Metagenomics;Microbe;microbial;microbiome;microbiome research;microbiota;microbiota composition;Modeling;Molecular;Multiomic Data;multiple omics;Nature;Onset of illness;Organoids;Pathogenesis;Patients;Phenotype;Positioning Attribute;Production;Regimen;Research;Research Personnel;Research Support;response;Risk;Role;Sampling;Severities;Shapes;Specimen;Technology;Testing;Therapeutic;therapeutic development;tool;Up-Regulation

PROJECT_TITLE: Toward parsing gut microbiota-epithelium-immune metabolic crosstalk in Celiac Disease

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Pediatric;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE We propose performing metagenomic deep sequencing on conjunctival and rectal swabs that have been collected as part of several previous NIH-funded trachoma studies. The proposed analyses will provide benchmarks for future studies of metagenomic deep sequencing for trachoma, and also provide information on the potential role of antimicrobial resistance, extraocular reservoirs of chlamydia, and non-chlamydial pathogens for persistent trachoma.

PI_NAMEs: KEENAN, JEREMY DAVID (contact)

PROJECT_TERMS: Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Appearance;Applications Grants;Area;Azithromycin;Benchmarking;Blindness;Child;Chlamydia;Chlamydia Infections;Chlamydia trachomatis;Clinical;Clinical Research;Cluster randomized trial;cohort;Communities;Conjunctivitis;cost effective;deep sequencing;DNA Maintenance;DNA Sequence;DNA sequencing;Dose;Effectiveness;Ethiopia;Frequencies;Funding;Future;Gene Expression;Gene Expression Profile;gene product;Genetic Determinism;Infection;Intervention;Knowledge;Macrolide-resistance;Measures;Metagenomics;Nasopharynx;Organism;pathogen;Persons;Peruvian;Pharmaceutical Preparations;Phenotype;Polymerase Chain Reaction;pressure;Randomized;Rectum;Reproducibility;Research;Resistance;resistance gene;RNA Sequences;Role;Sampling;Series;Site;Specimen;Speed;Surveys;Swab;Techniques;Testing;theories;Time;Tissue-Specific Gene Expression;Trachoma;transcriptome sequencing;transmission process;United States National Institutes of Health;World Health Organization

PROJECT_TITLE: Exploring the role of metagenomic deep sequencing for trachoma

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: NEW YORK

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Speech understanding benefit from cochlear implants is not instantaneous and requires months or sometimes years of perceptual adaptation. The goal of the proposed research is to characterize the process of perceptual adaptation to CI stimulation, and determine the extent to which the adaptation process may be facilitated to enhance CI outcomes.

PI_NAMEs: SVIRSKY, MARIO A (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TITLE: Perceptual Adaptation Following Cochlear Implantation

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Lymphatic Research;Lymphedema;Patient Safety;Prevention;Rare Diseases;Women's Health Research

ORG_DEPT: PLASTIC SURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE This clinical trial is focused on prevention of lymphedema by immediate lymphatic reconstruction (ILR) at the time of ALND in patients treated for inflammatory breast cancer (IBC), who have almost double the rate of lymphedema compared with the overall breast cancer patient population, to improve the quality-of-life in cancer survivors. The study proposal will determine the incidence of clinical lymphedema in IBC patients following ILR, establish a longitudinal, dynamic, imaging-based profile of changes in lymphatic vessel architecture and function following ILR using near-infrared fluorescence lymphatic imaging (NIRF-LI), and characterize longitudinal changes in serum inflammatory cytokines/ chemokines following this surgery, comparing these metrics in patients that develop lymphedema following ILR with those that do not. If successful, our work would provide impetus to change the surgical standard-of-care for patients with IBC and help direct the highest risk patients to specialized treatment centers for surgical intervention.

PI_NAMEs: ALDRICH, MELISSA B;SCHAVERIEN, MARK V (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Address;Anatomy;Architecture;arm;Axilla;Axillary Lymph Node Dissection;biomarker identification;biomarker panel;Blood;Breast Cancer Patient;Bypass;Cancer Center;Cancer Research Project;cancer surgery;cancer survival;Cancer Survivor;cancer therapy;Cells;Characteristics;chemokine;Clinic;Clinical;clinical diagnosis;Clinical Trials;cohort;Continuance of life;cytokine;Development;Diagnosis;Fluorescence;high risk;high risk population;Iatrogenesis;Image;Immune;improved;Incidence;Indocyanine Green;Inflammation;Inflammatory;inflammatory breast cancer;inflammatory marker;Intervention;Investigation;Legal patent;Limb structure;longitudinal analysis;Lymph;Lymph Node Dissections;lymph nodes;Lymphatic;lymphatic imaging;lymphatic vessel;Lymphedema;Malignant Breast Neoplasm;Measurement;Meta-Analysis;Microsurgery;Modality;Newly Diagnosed;Oncology;Operative Surgical Procedures;Outcome;Outcome Assessment;Outcome Measure;Patient Care;Patient Outcomes Assessments;patient population;Patient-Focused Outcomes;Patients;Pattern;peripheral blood;Personal Satisfaction;Persons;Physical therapy;Plasma;potential biomarker;predictive marker;prevent;Prevention;Procedures;profiles in patients;Publishing;Pump;Quality of life;Radiation therapy;reconstruction;Reconstructive Surgical Procedures;recruit;Reporting;Risk;Risk Reduction;Sampling;Serum;Specialized Center;Spectrum Analysis;standard of care;Swelling;Symptom Burden;Systemic Therapy;Techniques;Time;Transplantation Surgery;treatment center;Vascularization;Veins;Visualization;Work

PROJECT_TITLE: Lymphedema Prevention Through Immediate Lymphatic Reconstruction

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Immunization;Infectious Diseases;Vaccine Related;Women's Health Research

PHR: PROJECT NARRATIVE Vaginal candidiasis is a widespread fungal infection that affects over 75% of women. Approximately 15% of women experience vaginal yeast infections recurrently, resulting in serious impacts on quality of life and significant cost burden. There are no licensed vaccines to any fungal pathogens, and mechanisms of host immunity remain poorly understood. This project seeks to understand the role of specific immune cytokines in limiting infection.

PI_NAMEs: GAFFEN, SARAH L (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Adverse event;Affect;Anatomy;anti-fungal agents;Candida albicans;Candidiasis;cell injury;cell type;Cells;comparative;conditioning;cost;cytokine;Data;Disease;Environment;Epithelial Cells;Epithelium;Estradiol;Event;Exhibits;experience;FDA approved;female reproductive tract;fungus;Genetic;global health;Growth;High Prevalence;HIV/AIDS;Host Defense;Human;human female;IL17 gene;Immune;Immune response;Immunity;Immunocompetent;immunopathology;improved;Incidence;Infection;Inflammatory;interleukin-22;Learning;Licensing;Mediating;Mental Health;microbiome;Modeling;Mucous Membrane;Mus;Mycoses;Neutrophil Activation;Oral cavity;pathogenic fungus;Pathway interactions;Patients;permissiveness;Pharmaceutical Preparations;prevent;Property;Quality of life;receptor;Recurrence;recurrent infection;Regulation;Rodent;Role;Side;Signal Transduction;Site;Skin;System;Testing;Therapeutic Intervention;Tissues;transcription factor;Vaccine Design;Vaccines;Vagina;vaginal candidiasis;vaginal mucosa;Vulvovaginal Candidiasis;Woman;Zinc

PROJECT_TITLE: Mucosal host defense against vaginal candidiasis

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: LITTLE ROCK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the leading cause of death from a single infectious agent. The lack of understanding of the protective immunity against TB significantly hinders the development of more effective therapeutics and vaccines. This proposal seeks to define the underlying mechanism that regulate how lung alveolar macrophages (AMs) respond to early Mtb infection, allowing us to leverage AMs for novel host-directed therapies and more effective vaccines against TB.

PI_NAMEs: HUANG, LU  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: adaptive immune response;Address;Alveolar Macrophages;antimicrobial;Antimycobacterial Agents;arm;bacterial fitness;beta-Glucans;Bone Marrow;booster vaccine;Cause of Death;Cells;Cholesterol;conditional knockout;Consumption;Data;Development;Disease;Disease Progression;Embryo;Environment;Exhibits;experimental study;fatty acid oxidation;Fatty Acids;Foundations;Genomics;Glucose;Glycolysis;Granuloma;Growth;Human;Immune;Immunity;Immunology;in vivo;Infection;Infectious Agent;inhibitor;interdisciplinary approach;interstitial;Knockout Mice;Knowledge;Lesion;Link;Lung;Macrophage;Mediating;Memory;Metabolic;Metabolic Pathway;Metabolism;Microbiology;Modeling;monocyte;mouse model;Mus;Mycobacterium tuberculosis;Nature;novel;novel therapeutics;novel vaccines;Nutrient;Pathway interactions;permissiveness;Phenotype;Play;pressure;programs;rapid growth;Reporter;response;Role;Shapes;Testing;therapeutic vaccine;therapeutically effective;Training;transcriptome sequencing;transcriptomics;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;vaccine development;vaccine platform;Vaccines;Work

PROJECT_TITLE: Ontogeny and metabolism of lung alveolar macrophages in tuberculosis

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Legionella pneumophila (Lp), agent of a form of pneumonia known as Legionnaires’ disease, persists in a wide range of water systems due to its capacity to survive at high temperatures, grow in amoebae, and persist in biofilms, and once in the mammalian lung, flourishes by infecting macrophages. Independently of other components encoded within a Lp CRISPR-Cas locus, the Cas2 ribonuclease confers upon Lp the ability to survive heat shock, infect amoebae and macrophages, and form biofilms, and this novel, non-canonical function is due at least in part to the ability of Cas2 to promote the expression of a previously undefined heat shock protein (HspC2). Thus, the proposed studies seek to establish a new paradigm by deciphering how Cas2 controls the expression of the hspC2 gene to promote the thermal tolerance and virulence of a human pathogen.

PI_NAMEs: CIANCIOTTO, NICHOLAS P (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acanthamoeba castellanii;adaptive immunity;Address;Amoeba genus;Area;Bacteria;Bacterial Genes;BCAR1 gene;Binding;Binding Sites;Biomedical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Cytoplasm;Data;Defect;Development;Ferredoxin;Fostering;Gene Expression;Gene Expression Regulation;Gene Proteins;Genes;genetic element;Genetic Engineering;Genetic Transcription;Growth;Heat shock proteins;Heat-Shock Response;High temperature of physical object;Human;human pathogen;Immunity;Impairment;in vitro activity;Infection;insight;Invaded;Legionella pneumophila;Legionnaires' Disease;Link;Lung;Macrophage;Maps;Messenger RNA;Microbial Biofilms;Modeling;Molecular;mutant;Nature;novel;nuclease;Parasites;Pathogenesis;Phase;Phenotype;Physiology;Pneumonia;programs;Proteins;Quantitative Reverse Transcriptase PCR;Research Project Grants;Ribonucleases;Risk;RNA;RNA immunoprecipitation sequencing;RNA-Binding Proteins;Role;Site;Site-Directed Mutagenesis;System;Testing;Thermometers;trait;Transcript;Transcription Coactivator;United States National Institutes of Health;Virulence;Virulent;Water;Work

PROJECT_TITLE: Deciphering how the Cas2 ribonuclease non-canonically controls Legionella pneumophila thermal tolerance and virulence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BV-Y (91)]