ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS

ORG_CITY: COLLEGE STATION

ORG_DEPT: PHARMACOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE This proposal seeks to mechanistically develop and characterize age-appropriate dose-flexible pediatric co- delivery (combination) system of lamivudine and tenofovir disoproxil fumarate by selective laser sintering 3D printing method. It is expected that the quality, stability, palatability (human), pharmacokinetic and pharmacodynamic (safety and efficacy) profiles of dose-flexible pediatric co-delivery systems would be similar to commercial tablet formulations (Epivir, Viread® or CimduoTM), which are non-flexible. The pediatric delivery systems will meet FDA and USP requirements for eventual deployment in hospitals for pediatric use.

PI_NAMEs: KHAN, MANSOOR A (contact);RAHMAN, ZIYAUR

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: 3D Print;Acquired Immunodeficiency Syndrome;Address;Adherence;Adult;Adverse event;Age;age group;aged;Animal Model;Animals;Anti-Retroviral Agents;Anti-retroviral drug resistance;Anti-viral Therapy;antiretroviral therapy;appropriate dose;Biological Availability;Child;Childhood;Clindamycin;Clinical;Color;Combined Modality Therapy;Computer software;Data;Deglutition;Development;Diamond;Diclofenac;dosage;Dosage Forms;Dose;Drug Combinations;Drug Kinetics;Drug Modelings;Drug usage;efficacy evaluation;Environment;epivir;experience;Failure;flexibility;Formulation;Friends;Fumarates;Funding Mechanisms;HIV;HIV therapy;Hospitals;Hour;Human;improved;Incidence;innovation;isoniazid;Knowledge;Lamivudine;Lasers;liquid formulation;Liquid substance;Lopinavir;manufacture;Medical;melting;Methods;microbial;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;novel;Overdose;Overdose reduction;Patient Compliance;Patients;Pediatric Hospitals;pediatric human immunodeficiency virus;pediatric patients;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacy facility;Physicians;point of care;Population;Porosity;Preparation;Printing;Probability;Publishing;Recommendation;reduce symptoms;Reporting;Resources;Safety;safety assessment;Scientific Advances and Accomplishments;Scientist;Shapes;Solid;South Texas;Sterility;System;tablet formulation;Tablets;Taste preferences;Tenofovir;Therapeutic;therapy outcome;Titrations;Tongue;Toxic effect;treatment adherence;Treatment Efficacy;Treatment Failure;United States Food and Drug Administration;United States National Institutes of Health;Viral Load result;viral resistance;virtual;Work

PROJECT_TITLE: Dose Flexible Combination 3D-Printed Delivery Systems for Antiviral Therapy in Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-S(55)R]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_FIPS: US

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Exposure to cues associated with methamphetamine use can trigger relapse in recovering methamphetamine users, even after long periods of abstinence. To understand this persistent vulnerability, we study the nucleus accumbens, a key brain region for motivation and addiction, in a rat model of craving and relapse. Our studies will be the first to test the role of specific cell types in the nucleus accumbens and specific glutamate inputs to these cells in the synaptic plasticity that maintains high levels of methamphetamine craving during protracted withdrawal from methamphetamine self-administration.

PI_NAMEs: WOLF, MARINA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Abstinence;addiction;Adenosine;ADORA2A gene;Aftercare;Amygdaloid structure;Axon;Brain region;Cell Nucleus;cell type;Cells;Corpus striatum structure;craving;Cues;Data;designer receptors exclusively activated by designer drugs;Dopamine D2 Receptor;DRD2 gene;drug abstinence;drug of abuse;Electric Stimulation;Enterobacteria phage P1 Cre recombinase;Exhibits;Exposure to;Female;Fiber;Food;Genetic;Glutamate Receptor;Glutamates;Human;Incubated;Infusion procedures;Insula of Reil;Intralaminar Nuclear Group;Ligands;male;Measures;Mediating;Methamphetamine;methamphetamine use;methamphetamine user;Methamphetamine withdrawal;Modeling;Motivation;Neurons;Nose;Nucleus Accumbens;optogenetics;patch clamp;Pathway interactions;Permeability;Pharmaceutical Preparations;Photometry;Physiology;Prefrontal Cortex;presynaptic;Presynaptic Terminals;prevent;Progress Reports;Publications;Punishment;Rat Transgene;Rattus;Reaction Time;receptor;Relapse;Reporter;response;Rewards;Role;Saline;Self Administration;Slice;Structure of paraventricular nucleus of thalamus;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;Thalamic structure;Time;transmission process;Up-Regulation;Virus;Visualization;Withdrawal

PROJECT_TITLE: Glutamate receptor plasticity underlying incubation of methamphetamine craving

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Genetics;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

ORG_STATE: MA

PHR: Depression is a major public health problem; however, our understanding of and treatment for this  prevalent disorder remain lacking. Using an integration of state-of-the-art molecular and  functional imaging techniques in conjunction with a longitudinal design, the main goals of this  research are to (1) attain a better mechanistic understanding of MDD and anhedonia by focusing on a  novel target (Nociceptin/ Orphanin FQ receptors) expected to yield molecular abnormalities  associated with anhedonic phenotypes and stress- induced inflammatory abnormalities and (2)  identify abnormalities that map disease course.

PI_NAMEs: PIZZAGALLI, DIEGO A (contact)

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: Anhedonia;Animals;antagonist;Anterior;anti-depressive agents;Award;Behavioral;Binding;biological adaptation to stress;Brain region;cingulate cortex;Corpus striatum structure;cytokine;Depressed mood;depressive behavior;depressive symptoms;design;Disease;Disease remission;Etiology;follow up assessment;follow-up;Frequencies;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Goals;Hormonal;Imaging Techniques;Impairment;improved;Individual;Inflammatory;inflammatory marker;innovation;Knockout Mice;Learning;Life;longitudinal design;Major Depressive Disorder;Maps;Mental Depression;Messenger RNA;Molecular Abnormality;molecular imaging;neural;neuroimaging;neuroimaging marker;nociceptin;novel;ORL1 receptor;Participant;Pathway interactions;Peptide Receptor;Peptides;Peripheral Blood Mononuclear Cell;Phenotype;Play;Positron-Emission Tomography;pre-clinical;preclinical study;Prefrontal Cortex;Prevention;prospective;Psychological reinforcement;Public Health;Rattus;Recording of previous events;Regulation;Reporting;Research;response;reward processing;Rewards;Rodent;Role;social defeat;Stress;Stressful Event;Structural defect;Symptoms;System;Tracer;trait;Transcriptional Regulation;Up-Regulation;Ventral Tegmental Area;Work

PROJECT_TITLE: Neuroimaging Studies of Reward Processing in Depression

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Sustained viral infections, including infections with either prolonged or life-long viral replication, represent a major health problem worldwide. Importantly, the capacity of a virus to persist and cause disease is tightly related to the power and quality of the host immune response. We have identified two new ways in which CD8 T cells are regulated by adipose tissue after a viral infection and propose to characterize these novel immune- regulatory pathways and the underlying mechanisms.

PI_NAMEs: ZUNIGA, ELINA I (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Ablation;Acetyl Coenzyme A;Adipocytes;Adipose tissue;Affect;antiviral immunity;Avidity;Bioenergetics;Body Temperature;Brown Fat;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cell Lineage;Cell Respiration;Cells;Cellular Metabolic Process;Cessation of life;chronic infection;Communicable Diseases;Consumption;Data;Disease;Distant;effector T cell;Energy consumption;Energy-Generating Resources;Epigenetic Process;Equilibrium;exhaust;exhaustion;Exhibits;Genetic;Genetic Transcription;Glucose;Goals;Granzyme;Health;Histone Acetylation;House mice;Housing;Immune;Immune response;Immune system;Immunity;immunopathology;Immunotherapy;in vivo;Infection;insight;Left;Lipolysis;long chain fatty acid;Lymphocytic choriomeningitis virus;Maintenance;Mediating;Metabolic;Metabolism;metabolomics;Modeling;mouse model;Mus;Nonesterified Fatty Acids;novel;Nutrient;Nutrient availability;Nutritional;Outcome;oxidation;pathogen;Pathway interactions;Patients;Population;Population Heterogeneity;programs;receptor;Regulation;Regulatory Pathway;Research;response;Role;self renewing cell;Serum;stem-like cell;success;T cell response;T-Cell Development;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Temperature;Testing;therapy development;Thermogenesis;Tissues;Viral;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Inhibitory Pathways Underlying Viral Persistence In Vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-S(90)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Microbiome;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE PUBLIC HEALTH RELEVANCE: Immunotherapy (promoting an anti-tumor immune response) has demonstrated successful and exciting results in certain cancers, but not in patients with glioblastoma, a malignant brain tumor. Additionally, the composition of the gut microbiome has been shown to influence the efficacy of immunotherapy. Therefore, this proposal seeks to identify optimal microbial gut compositions to rescue resistance to immunotherapy for patients with glioblastoma.

PI_NAMEs: MCFARLAND, BRADEN COX (contact)

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: Address;Affect;Anti-CD47;anti-PD-1;anti-tumor immune response;antitumor effect;Behavior Therapy;beneficial microorganism;Bone Marrow;Cancer Model;CD47 gene;Cell Surface Proteins;Cells;Colon Carcinoma;Communities;CSF1R gene;Environment;fecal transplantation;Glioblastoma;gut bacteria;gut microbiome;gut microbiota;Human;Human Microbiome;human microbiota;Immune;immune activation;immune cell infiltrate;Immune checkpoint inhibitor;Immune Targeting;Immunologics;Immunotherapy;Infiltration;Inflammation;Inflammatory;inflammatory milieu;inhibitor;Innate Immune Response;Laboratory mice;Link;Macrophage;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Melanoma;Microbe;microbial;microbial community;microbiome;microbiome alteration;microbiome composition;Microglia;microorganism interaction;Modeling;mouse model;Mus;neoplastic cell;novel;Patients;Phagocytosis;Pharmaceutical Preparations;Phenotype;Population;pre-clinical;Pre-Clinical Model;probiotic therapy;Probiotics;public health relevance;Publishing;Reporting;Resistance;response;Role;Signal Transduction;T cell infiltration;T-Cell Activation;T-Lymphocyte;Target Populations;targeted treatment;Testing;Therapeutic;Therapeutic Uses;therapy resistant;translational potential;translational therapeutics;tumor;Tumor-associated macrophages;Work

PROJECT_TITLE: Employing Humanized Microbiome Mice to Understand Immune Activation and Translational Therapeutic Potential in Glioblastoma

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: Seattle

ORG_NAME: VIRTICI, LLC

ORG_STATE: WA

PHR: Project Narrative Infection with Neisseria gonorrhoeae (Ng) is an urgent public health threat, with both infection rates and antibiotic-resistance rising globally. An approved vaccine specifically for Ng does not yet exist, and treatment with extended-spectrum cephalosporins is the only reliable treatment remaining. Successful completion of this application will generate a new SL vaccine to prevent Ng infection, designed for robust Th1 immune responses and mucosal immunity, administered easily, and thermostable for rapid, global distribution.

PI_NAMEs: FANGER, NEIL A (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: Acceleration;Adjuvant;Advanced Development;Adverse event;Agonist;Aluminum;aluminum sulfate;Animals;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antibodies;Antibody Response;Antigens;Area;assault;Benchmarking;Biological Assay;Cefixime;Ceftriaxone;Cells;Cephalosporins;Cessation of life;Ciprofloxacin;Cold Chains;Communicable Diseases;Communities;Coupled;cross reactivity;Data;design;Disproportionately impacts women;Dose;drug development;Drug resistance;Drug-resistant Neisseria Gonorrhoeae;efficacy testing;Environment;epidemiologic data;Epithelium;female reproductive tract infection;Film;Formulation;Funding;Future;Goals;gonorrhea vaccine;Human;Immune;Immune response;Immunization;Immunize;improved;Individual;Industry;industry partner;Infection;Infection Control;infection rate;innovation;interest;Intramuscular;Investments;lot production;low and middle-income countries;Measures;Mediating;Modality;Modeling;mouse model;Mucosal Immune Responses;Mucosal Immunity;mucosal vaccination;Mucous Membrane;Mus;Neisseria gonorrhoeae;Neisseria meningitidis;Newborn Infant;nonhuman primate;novel;novel vaccines;Oral;pathogen;Pelvic Inflammatory Disease;Penicillins;Persons;Pharmacotherapy;Phase;Positioning Attribute;prevent;Production;programs;Property;Public Health;Recommendation;Research;resistant strain;Resources;response;Route;Safety;Self Administration;Shipping;side effect;Small Business Innovation Research Grant;Sodium Chloride;Sublingual drug administration;Surface;Symptoms;T cell response;Testing;Tetracyclines;thermostability;TLR4 gene;Translating;urogenital tract;Vaccination;Vaccine Adjuvant;vaccine delivery;vaccine development;vaccine efficacy;vaccine formulation;Vaccines;vaccinology;Work

PROJECT_TITLE: A Novel Sublingual Vaccine to Prevent Neisseria Gonorrhoeae Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-U(11)]


NIH_SPENDING_CATS: Brain Disorders;Depression;Genetics;Major Depressive Disorder;Mental Health;Mental Illness;Serious Mental Illness

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The research proposed here will contribute to an understanding of the causes major depressive disorder, the commonest psychiatric disorder and a leading cause of disability throughout the world. The proposal will improve our ability to diagnose depression from electronic health records, generate insights into the genetic architecture of depression, separating out specific from non-specific genetic risk factors, and will identify, from the analysis of sequencing data, genes that are involved in the etiology of the disorder. The research will provide new insights into disease, and well enable the development of more effective therapy.

PI_NAMEs: FLINT, JONATHAN  (contact);KENDLER, KENNETH SEEDMAN

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Algorithms;biobank;Biological;Biological databases;Biology;Bipolar Disorder;Clinical;clinical diagnosis;Code;cognitive change;cohort;comorbidity;Compensation;Computerized Medical Record;cost;Data;data imputation;deep learning;Development;Diagnosis;diagnosis standard;disability;Disease;dysphoria;effective therapy;Electronic Health Record;Etiology;exome;Factor Analysis;family genetics;Genes;Genetic;genetic approach;genetic architecture;Genetic Risk;genetic risk factor;Genetic study;genome wide association study;Genotype;Goals;Gold;Heritability;Heterogeneity;improved;Individual;insight;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Interview;Joints;Light;loss of function;Major Depressive Disorder;Measures;meetings;Mental Depression;Mental disorders;Methods;Moods;negative affect;non-genetic;novel;Pathogenicity;Pathway interactions;Patients;Phenotype;portability;Process;rare variant;Research;Risk;risk variant;Sample Size;Sampling;Schizophrenia;secondary outcome;Sequence Analysis;Signal Transduction;Silver;Specificity;Statistical Methods;Symptoms;Testing;Time;Tissues;trait;Variant

PROJECT_TITLE: Improving the interpretability of genetic studies of major depressive disorder to identify risk genes

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Mutations in the gene encoding the protein tau cause frontotemporal dementia and/or increase the risk of developing Alzheimer’s dementia. Tau plays important roles in brain cells (neurons) regulating the cytoskeleton, which is essential for formation and maintenance of the communication network that underlies neuronal function. We have discovered a novel neuroprotective pathway involving two proteins whose gene mutations contribute to frontotemporal dementia and Parkinson’s-related dementia. This proposal focuses upon understanding the mechanism(s) and neuroprotective potential of this pathway in patient-derived neuronal cells and a mouse model.

PI_NAMEs: CHU, CHARLEEN T (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Adaptor Signaling Protein;Affect;Alzheimer's Disease;Alzheimer's disease risk;ATP phosphohydrolase;Atrophic;Autophagocytosis;Binding;Biology;brain cell;Calcium;causal variant;Cell Death;Cells;cofactor;Communication;Cyclic AMP-Dependent Protein Kinases;Cytoskeleton;Data;Dementia;density;design;Down-Regulation;Endoplasmic Reticulum Degradation Pathway;familial Alzheimer disease;Frontotemporal Dementia;Gene Mutation;Genes;Genetic Models;Golgi Apparatus;Health;Impaired cognition;In Vitro;in vivo;Induced Mutation;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Interdisciplinary Study;Link;Maintenance;Mass Spectrum Analysis;Mediating;Methods;Mitochondria;Modeling;Molecular;mouse model;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;neuroprotection;novel;novel therapeutic intervention;Parkinson Disease;Parkinson's Dementia;Parkinsonian Disorders;parkinsonian model;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phosphorylation;Phosphotransferases;PINK1 gene;Play;prevent;protein degradation;Proteins;Quality Control;Risk;Rodent;Role;Signal Transduction;stem cell model;Synapses;tau dysfunction;tau expression;tau mutation;tau Proteins;Tauopathies;Testing;Toxin;Transgenic Mice;valosin-containing protein;Vertebral column;vesicle transport

PROJECT_TITLE: Neuronal quality control and neuroprotection in tauopathies

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: NARRATIVE This multidisciplinary project combines novel brain-penetrant and translatable PPAR agonists (KD3010, T3D- 959) and conditional cre/lox tools to manipulate PPAR function to test the role of brain PPARδ receptors in compulsive-like AUD phenotypes. Whole-body and brain-restricted transgenic approaches will specifically test the role of brain PPAR receptors in voluntary and aversion-resistant alcohol use as well as withdrawal- associated negative emotional behaviors; the effects of agonists and conditional knockouts on PPAR target gene expression will be studied with regional specificity. Collectively, the resulting data and novel tools for this understudied PPARδ isotype will lay the groundwork for cell type- and anatomically-specific mechanistic studies and may translate to interventions for people affected by AUD and potentially other forms of addiction.

PI_NAMEs: ZORRILLA, ERIC P (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: addiction;Addictive Behavior;Address;Affect;Affinity;Agonist;alcohol abuse therapy;Alcohol consumption;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholism;American Medical Association;Amygdaloid structure;Anatomy;Animal Model;Anxiety;Attention;Behavior;Behavior Disorders;behavior measurement;Bioenergetics;Biology;Blood - brain barrier anatomy;Brain;Carrier Proteins;CD3D gene;cell growth regulation;cell type;Chemicals;Chronic;CNR1 gene;conditional knockout;Corpus striatum structure;Coupled;Data;Development;Dose;Drug Modelings;Emotional;emotional behavior;Epigenetic Process;Ethanol;Ethanol Metabolism;Exercise;fatty acid-binding proteins;Gene Expression;Genes;Genetic;Genetic Recombination;Genotype;GTP-Binding Proteins;Homeostasis;Human;insight;Intervention;Knock-out;Knockout Mice;Knowledge;Laboratory Study;Lifestyle-related condition;Ligand Binding;Ligands;Lipids;Mediator;Medical;Membrane;Metabolic;mimetics;Mitochondria;Modeling;Molecular;multidisciplinary;Mus;nerve stem cell;nestin protein;Neurobiology;neuroinflammation;novel;Nuclear;Nuclear Receptors;Pathway interactions;Peripheral;Peroxisome Proliferator-Activated Receptors;Persons;pharmacologic;Phenotype;PPAR delta;pre-clinical;preference;Prefrontal Cortex;receptor;Receptor Activation;Receptor Inhibition;Regulation;Resistance;response;Rewards;Role;Self Administration;Signal Transduction;Site;Skeletal Muscle;Specificity;Stress;Substance Use Disorder;Testing;Therapeutic;therapeutic target;tool;transcription factor;transcriptomics;Transgenic Organisms;Translating;vapor;Withdrawal

PROJECT_TITLE: PPARdelta receptors and alcohol use phenotypes

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: TITLE: The eXtraordinarY Babies Study - Natural History of Health and Neurodevelopment in Children with Sex Chromosome Trisomy NARRATIVE: Sex Chromosome Trisomies (SCT), including Klinefelter (XXY), Trisomy X (XXX), and XYY syndromes, are the most common chromosomal abnormalities, occurring in 1 out of every 400 births or over 10,000 births per year in the US. The prenatal diag- nosis rate of SCT has been increasing, and children born with SCT have a significantly increased risk for: (1) neurodevelopmen- tal problems including developmental delays, speech-language disorders, learning disabilities, ADHD, autism spectrum disor- ders (ASD), and (2) medical comorbidities including testicular/ovarian failure, disorders of insulin resistance, seizures, congeni- tal malformations, and other medical problems. The eXtraordinarY Babies Study will prospectively describe the natural history of children with a prenatal diagnosis of SCT through 7-8 years of age, building on data collected from a group of 260 infants with SCT recruited during the first funding cycle who were comprehensively evaluated from infancy to 3-4 years of age with a focus on identifying developmental and hormonal predictors of neurodevelopmental and health outcomes. Results will lead to a comprehensive understanding of the natural history and variability in SCT conditions, will identify targets for interven- tions, and will inform clinical care and genetic counseling guidelines for the increasing number of prenatal and early childhood diagnoses of SCT.

PI_NAMEs: TARTAGLIA, NICOLE RENEE (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: 4 year old;7 year old;8 year old;Address;Age;Age Months;Age Years;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;autism symptoms;Behavior;biobank;Biological;Biological Markers;Biological Specimen Banks;Birth;Blood;Body Composition;cardiometabolism;Caring;Child;Childhood;Chromosome abnormality;Clinic;Clinical;clinical care;Cognitive;cohort;Cohort Studies;Common Data Element;comorbidity;Congenital Abnormality;Counseling;Coupled;Data;data repository;data sharing;demographics;Dental;Development;Developmental Delay Disorders;Diagnosis;Disease;Dual-Energy X-Ray Absorptiometry;Dyslexia;early childhood;Education;Emotional disorder;Endocrine;Enrollment;Environment;ethnic minority population;Ethnic Population;evidence base;experience;Eye;Failure;Family;Fatty acid glycerol esters;feeding;follow-up;Functional disorder;Funding;Future;Genetic;Genetic Counseling;Goals;Gonadal Steroid Hormones;Growth;Guidelines;Health;heart defect;high risk;Hormonal;Hormones;improved;infancy;Infant;infant outcome;Insulin Resistance;interest;Intervention;Intervention Trial;Investigation;Klinefelter's Syndrome;Language Development;Language disability;Language Disorders;Learning Disabilities;Length;Life;Linear Models;literacy;Logistic Regressions;Longitudinal Studies;low socioeconomic status;Measures;Medical;Medical Genetics;Methods;Modeling;Morbidity - disease rate;mortality;Motor;Motor Skills;Natural History;Neonatal Screening;neurodevelopment;Neurodevelopmental Problem;Neuropsychology;Newborn Infant;novel;Obesity;Outcome;outcome prediction;ovarian failure;Parents;Participant;Pathway interactions;patient oriented;penis;Phase;Phenotype;Population;premature;prenatal;Prenatal Diagnosis;Prenatal Genetic Counseling;prenatal testing;prospective;Prospective Studies;Protocols documentation;psychologic;Quality of life;racial minority population;racial population;reading ability;Reading Disabilities;Recording of previous events;recruit;Resources;Risk;Risk Factors;risk selection;rural area;Sample Size;Sampling;School-Age Population;Seizures;Sex Chromosomes;Shapes;Site;skills;Social Development;Socioeconomic Status;Speech;standardize measure;Statistical Models;stool sample;Stress;Supplementation;Syndrome;Testing;Testosterone;Torticollis;Trisomy;Trisomy X syndrome;Underrepresented Populations;Urine;visual tracking;Work;XYY Karyotype

PROJECT_TITLE: The eXtraordinarY Babies Study: Natural History of Health and Neurodevelopment in Infants with Sex Chromosome Trisomy

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Pediatric;Precision Medicine

ORG_CITY: BETHLEHEM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: LEHIGH UNIVERSITY

PHR: Project Narrative Psychiatric disorders are among the most common illnesses across the lifespan and highlight the importance of cognitive and mental health in youth development. In this project, we will develop sophisticated analytical tools with high-density EEG to discover neural circuits associated with behavioral phenotypes spanning multiple psychiatric disorders for an improved understanding of psychopathology. Successful outcomes of the project will produce translatable biomarkers crossing current diagnostic boundaries and provide a new avenue for functional connectivity-based transdiagnostic study of psychopathology, thereby laying the foundation for the development of personalized therapeutics toward improved cognitive function and mental health.

PI_NAMEs: BERDICHEVSKY, YEVGENY  (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Adolescence;Adolescent;analytical tool;Anxiety;Architecture;Behavior;behavior measurement;Behavioral;behavioral phenotyping;Biological Markers;Brain;brain behavior;brain dysfunction;Case/Control Studies;Categories;Child;clinical translation;clinically relevant;Cognition;Cognitive;cognitive ability;Cognitive deficits;cognitive function;comorbidity;Complement;connectome based predictive modeling;cost effective;Data;Databases;density;design;Development;Diagnostic;diagnostic biomarker;dimensional analysis;Dimensions;Disease;efficacy evaluation;Electroencephalography;Foundations;Functional impairment;Functional Magnetic Resonance Imaging;Goals;Health;Human;Impaired cognition;improved;Individual;innovation;life span;Link;Maps;Measures;Mental disorders;Mental Health;Modeling;Moods;National Institute of Mental Health;neural;neural circuit;neural correlate;Neurobiology;neuroimaging;open source;Outcome;Pattern;personalized therapeutic;Phenotype;predictive marker;predictive modeling;Psychiatry;Psychopathology;Publishing;Research;Research Domain Criteria;Rest;Signal Transduction;Source;source localization;Symptoms;Testing;tool;Variant;vector;Youth

PROJECT_TITLE: Identifying Transdiagnostic Functional Connectivity Biomarkers for Cognitive Health and Psychopathology

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: Project Narrative Prostate cancer develops in a microenvironment where growth and progression are governed by complex and reciprocal interactions between tumor cells and surrounding stromal elements. The proposed studies aim to define the functional and mechanistic roles of monoamine oxidase B, a novel therapeutic target in prostate cancer stromal fibroblasts, and its downstream effectors in reprogramming prostate cancer stroma and mediating epithelial-stromal crosstalk promoting prostate cancer. Our studies will provide new fundamental knowledge of the molecular basis of prostate cancer development and progression in the context of its microenvironment, laying the foundations for new single or combination therapies capable of rapid clinical translation to treat prostate cancer, especially lethal castration-resistant and neuroendocrine prostate cancer.

PI_NAMEs: WU, BOYANG  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: 3-Dimensional;Ablation;Affect;Allografting;Amines;Androgen Antagonists;androgen independent prostate cancer;Antibodies;Binding;Bioinformatics;Biological;BLR1 gene;cancer care;cancer prevention;carcinogenesis;Castration;cell behavior;Cell Proliferation;Cells;Cessation of life;chemokine;Chemotaxis;Clinical;clinical application;clinical translation;Clinical Trials;Coculture Techniques;cohort;Collection;Combined Modality Therapy;Communication;Complement;Complex;Coupled;CRISPR/Cas technology;CXCL13 gene;D Cells;Development;dietary;Disease;Disease Progression;druggable target;efficacy evaluation;Elements;Enzymes;epidemiology study;Epithelium;Fibroblasts;Foundations;Future;Gene Expression Profiling;gene network;Genes;genetic resistance;Genetic Transcription;Goals;Growth;Hormones;Human;Hydrogen Peroxide;Immunocompetent;Immunocompromised Host;Incidence;Inflammatory;inhibitor;Intervention;Invaded;Knock-out;Knowledge;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;men;Mental Depression;Mitochondria;Mitochondrial Proteins;Molecular;monoamine;Monoamine Oxidase B;mouse model;Mus;Mutation;Neoplasm Metastasis;neoplastic cell;Nervous System Disorder;neuroendocrine differentiation;Neuroendocrine Prostate Cancer;Neurotransmitters;new therapeutic target;novel;Oxidative Stress;paracrine;Pathologic;Patients;Phenotype;pre-clinical;Predisposition;promoter;Prostate;prostate cancer cell;prostate cancer model;Prostate Cancer therapy;Prostatic Neoplasms;PTEN gene;Reactive Oxygen Species;Recombinants;Recurrence;Recurrent disease;Recurrent tumor;Resistance;response;Risk;Role;Sampling;Signal Pathway;Source;Specimen;Stromal Cells;Stromal Neoplasm;success;targeted treatment;therapeutic target;therapy resistant;Time;Tissues;Transforming Growth Factor beta;Transgenic Mice;translational impact;tumor growth;tumor microenvironment;tumor progression;tumorigenic;United States;wound healing;Xenograft procedure

PROJECT_TITLE: Deciphering Mechanisms of Tumor-Stromal Interactions in Prostate Cancer

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Nutrition

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: The proposed work will illuminate the role of a previously uncharacterized hippocampal-lateral septum-lateral hypothalamic circuit in regulating how our environmental cues govern feeding behavior, which may shed light on the neural circuit bases for eating disorders.

PI_NAMEs: GOODE, TRAVIS DAVID (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Animals;Appetitive Behavior;approach behavior;base;Behavior;Behavioral Paradigm;Brain;Calcium;Calibration;cell type;Cells;Chronic;Consummatory Behavior;Consumption;Cues;Data;Dependence;Desire for food;Dissection;Dorsal;Eating;Eating Disorders;Electrophysiology (science);Environment;Exhibits;experimental study;Familiarity;Fasting;feeding;Feeding behaviors;Female;Food;food avoidance;food consumption;Frequencies;Future;Glutamates;Goals;Hippocampus;Home;Hunger;Hypothalamic structure;Image;improved;in vivo;Individual;inhibitory neuron;Inhibitory Synapse;insight;Laboratories;Lateral;Life;Link;male;Mediating;Modeling;Molecular;motivated behavior;Motivation;Mus;nerve supply;neural;neural circuit;Neurons;Neuropeptides;new therapeutic target;novel;novel therapeutics;optogenetics;Outcome;Pathway interactions;Pattern;Phase;Population;Positioning Attribute;prevent;Process;prodynorphin;proenkephalin;programs;recruit;Regulation;Research;Rewards;Role;Satiation;Signal Transduction;single cell sequencing;Slice;Specificity;Structure;Synapses;System;Techniques;Testing;Training;transcriptomics;transmission process;Work

PROJECT_TITLE: A Genetically Defined Lateral Septum Circuit for Contextual Calibration of Food Reward-Seeking


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Opioid-related overdose death is the single largest cause of accidental death in the United States, and individuals being released from incarceration are at particular risk, with some studies showing their risk of death in the weeks immediately after release is as much as 129 times that of the general population. In January 2020 the Los Angeles Sheriff’s Department began giving people being released from jail naloxone, a medication which can be used to ‘reverse’ overdose, in order to try and reduce overdose deaths among people being released and also in the communities they return to after release. This study will use a range of methods to examine whether the program is effective at getting naloxone to where it is most needed, and whether it reduces deaths among people being released and in the communities to which they return.

PI_NAMEs: DAVIDSON, PETER JOHN (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Accidents;Address;African American;Area;Black race;Cessation of life;Characteristics;cohort;Cohort Studies;Communities;cost;cost effective;County;Criminal Justice;Cross-Sectional Studies;Data;Data Analyses;Death Rate;design;Diffusion of Innovation;Dose;Drops;Drug usage;Equity;Ethnic Origin;experience;Exposure to;General Population;Goals;Grant;high risk;high risk population;Imprisonment;Individual;innovation;interest;Intervention;Interview;Jail;Knowledge;Latinx population;Literature;Los Angeles;Methods;mortality;mortality risk;Naloxone;naloxone dispensing;naloxone dosing;Needle-Exchange Programs;Opioid Antagonist;opioid mortality;opioid overdose;opioid use;opioid user;Outcome;Overdose;overdose death;overdose education;overdose prevention;Overdose reduction;Overdose reversal;overdose risk;Paper;Persons;Pharmaceutical Preparations;Policies;Population;Program Description;programs;Provider;Public Health;Race;Recording of previous events;recruit;response;Risk;Sampling;Scotland;Self Administration;social;Surveys;System;Training;underserved community;Underserved Population;United States;Work

PROJECT_TITLE: Evaluating naloxone-on-release from incarceration as community overdose prevention

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: Washington

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: AMERICAN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE/PUBLIC HEALTH IMPACT STATEMENT In this study, we will examine the efficacy of Safe South Africa, a behavioral intervention that is developmentally- and gender-tailored to prevent human immunodeficiency virus (HIV) and intimate partner violence (IPV) among adolescent boys. South Africa faces some of the highest global rates of HIV and IPV with sustained high incidence of HIV and alarming rates of IPV among adolescents and thus, is an ideal site to advance prevention science to tackle these urgent public health priorities. Testing the efficacy of an integrated intervention to prevent HIV risk behavior and IPV for adolescent boys can support optimal health for young people, their future partners, and society.

PI_NAMEs: KUO, CAROLINE CHIA (contact);MATHEWS, CATHERINE

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adolescence;Adolescent;Adolescent HIV risk;Affect;Africa South of the Sahara;Age;age group;AIDS prevention;Attitude;Behavior;Behavior Therapy;Behavioral;Biological;boys;Communities;Continuity of Patient Care;Country;Data;Development;Dissemination and Implementation;Education;efficacy evaluation;efficacy testing;efficacy trial;Environment;Epidemic;experience;Face;Forcible intercourse;Frequencies;Future;Gender;Goals;Government;Health;high risk;high risk sexual behavior;HIV;HIV risk;HIV/STD;improved;Incidence;Individual;Infection;innovation;Interpersonal Violence;Intervention;intervention delivery;Interview;intimate partner violence;life span;Male Adolescents;Manuals;Medical Research;men;Minority Groups;Outcome;Outcome Assessment;peer;personalized approach;Persons;Population;population based;post implementation;post intervention;pressure;Prevalence;prevent;Prevention;Prevention approach;Preventive;preventive intervention;Problem behavior;Process;programs;Public Health;public health priorities;Randomized;Reporting;Research;Risk;Risk Behaviors;Role;scale up;Schools;Science;sex;Sexual Partners;sexual violence;Shapes;Site;social influence;social norm;Societies;South Africa;South African;Standardization;Strategic Planning;structural determinants;Surveys;synergism;systematic review;Testing;theories;Theory of Change;treatment as usual;United States National Institutes of Health;Violence;violence perpetration;violence prevention;Work

PROJECT_TITLE: Testing the Efficacy of Safe South Africa: An Intervention to Prevent HIV Risk and Interpersonal Violence Among Adolescent Boys

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Boulder

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

PHR: Skeletal muscle is essential for life, with reductions in muscle health contributing to loss of life quality, morbidity that overburden our health care. Understanding how muscle health is maintained and the contribu- tions of muscle stem cells is the central goal of our proposal.

PI_NAMEs: OLWIN, BRADLEY B (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Affect;Aging;Anatomy;Basement membrane;cell behavior;Cell division;Cell fusion;Cell membrane;Cell Nucleus;Cell Proliferation;Cell Transplantation;Cells;combat;Coupled;Data;daughter cell;Disease;Ensure;Environment;experimental study;Fibroblasts;flexibility;Genetic Transcription;Goals;Health;Healthcare;Heterogeneity;Hypertrophy;improved;Injury;Knowledge;Life;Maintenance;Methodology;Methods;Mitotic;Mononuclear;Morbidity - disease rate;Muscle;Muscle Fibers;Muscle function;muscle progenitor cell;muscle regeneration;muscle repair;Muscle satellite cell;Myoblasts;Myopathy;novel;novel strategies;Nuclear;Parents;Peripheral;Population;Population Heterogeneity;Positioning Attribute;prevent;Production;progenitor;Proliferating;Quality of life;repaired;Signal Pathway;Signal Transduction;single cell sequencing;Skeletal Muscle;stem cell homeostasis;stem cells;Technology;therapeutic development;therapeutic target;Tissues;transcriptomics

PROJECT_TITLE: Mechanisms Regulating Muscle Stem Cell Homeostasis

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE A major therapeutic gap exists in relapsed/refractory diffuse large B cell lymphoma (DLBCL) – a disease against which immunotherapies have shown significant progress; however, the impact of the DLBCL immune environment on immunotherapy response is not known, and knowledge regarding the influence of lymphoma- intrinsic oncogenic pathways on shaping the DLBCL immune environment is lacking. To fill these gaps in knowledge, we have characterized immune landscapes associated with DLBCL using transcriptional profiling and have uncovered several recurrent mutations that appear to play key roles in sculpting the immune environment in this disease, which will be mechanistically characterized in this proposal. Furthermore, having established the existence of unique DLBCL immune environments, we will develop a DLBCL “immune score” that may predict responsiveness to immunotherapies including PD-1 blockade and CAR T cell therapy.

PI_NAMEs: KLINE, JUSTIN P. (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Address;Affect;aggressive therapy;anti-PD1 antibodies;anti-PD1 therapy;Antigen Presentation;Area;B-Cell Activation;B-Lymphocytes;cancer cell;CAR T cell therapy;CD47 gene;Cell membrane;Cell Shape;Cells;checkpoint therapy;chimeric antigen receptor T cells;Classification;Clinical;Clinical Trials;combat;Data;Development;Diagnostic;Disease;DNA Sequence Alteration;effective therapy;Elements;Ensure;Environment;Exhibits;exome sequencing;experimental study;Gene Amplification;Gene Expression Profiling;Genes;genetic selection;Genetic Transcription;Genomics;Immune;immune checkpoint blockade;Immunotherapy;Interferon Type II;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;Lead;loss of function;loss of function mutation;Lymphoma;Lymphoma cell;Macrophage;Malignant - descriptor;Modeling;Mus;Mutate;Mutation;Non-Hodgkin's Lymphoma;Oncogenic;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;PD-1 blockade;Phagocytosis;Phenotype;Phosphatidylserines;Physicians;Play;pre-clinical;predicting response;Predisposition;Principal Investigator;programmed cell death ligand 1;Property;recruit;Recurrence;Refractory;Relapse;Research;response;Role;Scientist;segregation;Shapes;Signal Transduction;skills;Solid Neoplasm;Specimen;Stem cell transplant;Structure of germinal center of lymph node;T cell therapy;T-cell inflamed;T-Lymphocyte;Therapeutic;transcriptome;Transplantation;Treatment Efficacy;treatment response;tumor;tumor immunology;tumor microenvironment;Variant

PROJECT_TITLE: Integrative approach to identify genomic features that shape the immune landscape and predict immunotherapy response in diffuse large B cell lymphoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


NIH_SPENDING_CATS: Aging;Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: GENETICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Motor neuron diseases including Amyotrophic lateral sclerosis (ALS) involve loss of axons, including the essential connections between the spinal cord and muscles. Lactate metabolism plays an important role in nervous system health. We will explore findings that implicate abnormalities in lactate pathways in motor axon function and in progression of ALS disease symptoms, with a goal of developing new treatments for this disease.

PI_NAMEs: MILBRANDT, JEFFREY D (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Acceleration;Affect;Afferent Neurons;Affinity;ALS patients;Amyotrophic Lateral Sclerosis;Axon;axonal degeneration;Axonal Transport;Biochemical;Biological Assay;cell type;Cells;Cellular Metabolic Process;Complement;Consumption;Coupling;Dependence;Development;Disease;Disease Progression;disorder risk;early onset;Etiology;experimental study;Genes;genetic risk factor;Genetic Transcription;glucose metabolism;Goals;Health;Health system;Heterozygote;Impairment;in vivo Model;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Isotope Labeling;Knock-out;Knockout Mice;Knowledge;Lactate Dehydrogenase;loss of function;Measures;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Motor;motor deficit;motor disorder;motor neuron development;Motor Neuron Disease;Motor Neurons;motor symptom;mouse model;Mus;Muscle;Mutant Strains Mice;Mutation;Nervous System;Neuroglia;neuroinflammation;Neurons;Neuropathy;Onset of illness;oxidative damage;Pathogenesis;Pathogenicity;Pathologic Processes;Pathway interactions;Patients;Peripheral;Peripheral Nervous System;Peripheral Nervous System Diseases;Phenotype;Play;Process;protein folding;Protein Isoforms;protein TDP-43;Pyruvate;Pyruvate Metabolism Pathway;Regulation;response;Risk;Risk Factors;RNA Processing;Role;Schwann Cells;Sensory;Specificity;Speed;Spinal Cord;superoxide dismutase 1;Supporting Cell;Symptoms;synergism;Testing;Therapeutic;Variant

PROJECT_TITLE: Compromised LDH activity causes motor deficits and hastens ALS progression


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Digestive Diseases;Liver Disease;Rehabilitation;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE Alcohol use disorders (AUDs) represent a leading health issue that causes an enormous number of deaths and disabilities globally, highlighting the critical medical need for the development of novel therapeutic strategies. We have designed, synthesized, and characterized a novel small molecule YA7068 that inhibits ALDH2 with excellent potency, while also acting as a substrate for the hepatocyte-specific organic anion transporting polypeptide 1B1 (OATP1B1). Our goal is to synthesize and test a series of YA7068 analogs using established assays, to identify, validate, and characterize potent liver specific ALDH2 inhibitors as a potential treatment for AUDs.

PI_NAMEs: XUE, FENGTIAN  (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Acetaldehyde;Acetates;Active Sites;Address;alcohol abuse therapy;Alcohol consumption;Alcohol dehydrogenase;Alcohol dependence;alcohol seeking behavior;alcohol use disorder;Alcoholic Liver Cirrhosis;aldehyde dehydrogenases;Alleles;analog;Asian ancestry;Biological Assay;Blood;Cardiac;Cell surface;Cells;Cessation of life;Clinical;Computer Assisted;Computer-Aided Design;Coumarins;Coupling;Dangerousness;Data;design;deter alcohol use;Development;disability;disease model;Disulfiram;drinking;Drug Design;drug development;Drug Kinetics;Drug Targeting;East Asian;effective therapy;end-stage organ failure;Energy Metabolism;Enzymes;Ethanol;Face;Family;Feeling;Flushing;Gene Deletion;Goals;Half-Life;Headache;Health;Heavy Drinking;Hepatocyte;Human;Human body;Hypotension;In Vitro;in vitro Assay;in vivo;in vivo evaluation;Individual;inhibitor;Isoenzymes;Knockout Mice;lead optimization;Letters;Ligands;Liver;liver function;Maps;Maximum Tolerated Dose;Medical;Metabolic Clearance Rate;Metabolism;Methodology;Methods;Mitochondria;Motility;mouse model;Mus;National Institute on Alcohol Abuse and Alcoholism;Nausea;novel;novel therapeutic intervention;OATP Transporters;Palpitations;Persons;pharmacologic;Population;Positioning Attribute;Prevention strategy;Reaction;Reporting;Research;Research Priority;Resistance;Risk;Role;Series;side effect;Site;small hairpin RNA;small molecule;Specificity;Spottings;Structure;Structure-Activity Relationship;Surface;Tachycardia;Testing;Therapeutic;Toxic effect;treatment strategy;uptake;virtual screening

PROJECT_TITLE: ALDH2 inhibitors for the treatment of AUD

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: NR

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cystic Fibrosis;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Organ Transplantation;Rare Diseases;Social Determinants of Health;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Our work aims to promote equitable access to lung transplant in a vulnerable population using up-to-date, cystic fibrosis-specific lung transplant education that supports self-efficacy and patient-empowerment in health care decisions. High-quality lung transplant discussions could improve clinical and psychological outcomes by changing attitudes, beliefs, and choices related to transplant. The Take on Transplant lung transplant decision support tool has the potential to expand the toolbox for engaging patients with cystic fibrosis in high-quality lung transplant discussions and aims to narrow the gap in access to transplant for individuals in disadvantaged groups, including those with lower socioeconomic status, non-White race, or Hispanic ethnicity.

PI_NAMEs: RAMOS, KATHLEEN JESSICA (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Address;Adult;Age;Anxiety;attentional control;Attitude;Belief;Caregivers;Cessation of life;Clinic Visits;Clinical;Collaborations;Communication;Communities;Complex;Comprehension;Cystic Fibrosis;cystic fibrosis patients;Data;Decision Aid;Decision Making;Disadvantaged;Discrimination;Disease;Disparity population;Education;efficacy study;efficacy testing;Eligibility Determination;Emotional;empowerment;Enrollment;Equity;Ethnic Origin;Evaluation;experience;Focus Groups;Foundations;gaps in access;Genetic Diseases;Guidelines;Health;health disparity;Health Professional;Healthcare;Hispanic;implicit bias;improved;Individual;interest;Intervention;Interview;Knowledge;low socioeconomic status;Lung Transplantation;Measures;Medical;Mental Depression;Methods;mortality risk;National Institute of Nursing Research;Not Hispanic or Latino;Online Systems;patient engagement;Patient Preferences;Patients;Perception;personal narratives;Persons;Pharmaceutical Preparations;Physicians;point of care;Preparation;primary outcome;Process;prognostic;Psychological Impact;psychological outcomes;psychosocial;Psychosocial Assessment and Care;Psychosocial Factor;Pulmonary Function Test/Forced Expiratory Volume 1;Race;randomized, clinical trials;Readiness;Recommendation;Reporting;Research;Research Priority;Resources;Sampling;Self Efficacy;Single-Blind Study;social;Social Network;Structure;support tools;Surveys;Testing;Time;Transcript;Transplantation;Uncertainty;Vulnerable Populations;VX-770;web site;Work

PROJECT_TITLE: Preparation for lung transplant discussions and decisions among people with cystic fibrosis

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Anorexia;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Eating Disorders;Genetics;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Nutrition;Pediatric;Serious Mental Illness

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE Eating disorders, including anorexia/bulimia nervosa and binge eating disorder, have their peak onset during adolescence but their etiological underpinnings are still largely unknown, leading to poor treatment outcomes and even mortality. This study will be the first to prospectively study the genetic, neuroimaging and behavioral factors that precede onset of an eating disorder in adolescence using data from the Adolescent Brain Cognitive Development (ABCD) Study, as well as integrating independently collected clinical data to examine how putative premorbid factors translate to clinical outcomes. Infusing a neurobiological perspective to an etiological model of eating disorders will offer valuable directions for future treatment plans and clinical assessments early in the course of illness.

PI_NAMEs: MAKOWSKI, CAROLINA  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 16 year old;18 year old;Adolescence;Adolescent;Adult;Affect;Age;Age of Onset;Anorexia;Anorexia Nervosa;Area;associated symptom;Award;Behavior;behavior measurement;Behavioral;Binding;Binge eating disorder;Brain;Brain imaging;brain tissue;Bulimia;case control;Categories;Clinical;Clinical assessments;Clinical Data;cognitive development;Corpus striatum structure;cost;Data;Data Collection;Data Discovery;Data Set;Development;Diagnosis;Diagnostic;diagnostic criteria;Diffusion;Disease;disorder control;Eating Disorders;Etiology;Exhibits;Female;Female Adolescents;Future;Genetic;Genetic Risk;Genetic study;Genomics;Health;Heritability;Heterogeneity;Image;imaging modality;Imaging Techniques;improved;Individual;innovation;Insula of Reil;Investigation;Lead;longitudinal dataset;longitudinal, prospective study;Machine Learning;machine learning method;Magnetic Resonance Imaging;male;Measures;Mediating;Mentors;Mentorship;Methodology;Methods;Modeling;Morphology;mortality;multimodality;Neuroanatomy;Neurobiology;neurodevelopment;neuroimaging;neuroimaging marker;Onset of illness;Outcome;Participant;patient prognosis;Patient-Focused Outcomes;Patients;Personal Satisfaction;Phase;Phenotype;physical conditioning;polygenic risk score;Positioning Attribute;predict clinical outcome;Predictive Factor;predictive modeling;Prevalence;programs;Property;prospective;Prospective Studies;Publishing;Reporting;Research;Research Design;Restriction Spectrum Imaging;Risk;Risk Factors;Sampling;Severity of illness;Site;skills;statistics;Structure;support vector machine;Surface;Symptoms;Techniques;Thick;Training;trait;Translating;Treatment outcome;treatment planning;white matter;women patients;Work

PROJECT_TITLE: Towards an etiological model of adolescent eating disorders through neuroimaging, genetics, and behavior


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: WORCESTER

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: NARRATIVE Medical toxicologists have increasing roles in the management of poisoned patients, adverse drug events, novel therapeutics and substance use disorder (SUD). Despite their critical role in the care of patients with SUD, few medical toxicologists achieve federal funding or receive formal instruction in hypothesis driven research. This proposal establishes the Advancing New Toxicology Investigators in Drug abuse and Original Translational research Efforts (ANTIDOTE) Institute in collaboration with the American College of Medical Toxicology to facilitate research methodology skills in medical toxicologists interested in substance use disorder research.

PI_NAMEs: CARREIRO, STEPHANIE P (contact);CHAI, PETER R

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Acceleration;Address;Adverse drug event;American;Awareness;behavior change;Behavioral;Behavioral Sciences;Board Certification;career;Career Mobility;Caring;Clinical;cohort;Collaborations;comorbidity;Data;Dedications;Development;Diagnosis;Discipline;Drug abuse;Education Gap;Educational Curriculum;Epidemic;Epidemiology;Evaluation;experience;Faculty;Funding;Goals;Grant;Group Meetings;Health;Health system;Hybrids;innovation;Instruction;interdisciplinary approach;interest;Investigation;knowledge translation;Learning;Learning Skill;Measures;Medical;medical schools;medical specialties;Medicine;meetings;member;Mental disorders;Mentors;Mentorship;Methodology;Modeling;multidisciplinary;National Institute of Drug Abuse;next generation;novel therapeutics;outreach;Patient Care;Patients;Persons;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacotherapy;Physicians;Poison;Poisoning;Population;Positioning Attribute;Program Development;Program Evaluation;programs;Public Health;Reaction;Records;recruit;Research;research and development;Research Methodology;Research Personnel;response;Role;satisfaction;Scientist;skill acquisition;skills;social stigma;Structure;Substance of Abuse;Substance Use Disorder;success;theories;Therapeutic Uses;tool;Toxicology;Training;Training Programs;Translating;Translational Research;Trauma;United States;virtual;virtual group;Writing

PROJECT_TITLE: The ANTIDOTE Institute- Advancing New Toxicology Investigators in Drug abuse and Original Translational research Efforts


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Without access to an integrated approach to diagnosis, research, and care, many patients with rare conditions go from one institution to the next without finding answers or making progress with their care. This leads to poor outcomes for patients and families and poses a burden on our healthcare system. As part of this project, we will create sustainable, national infrastructure to address this unmet need for those who are undiagnosed.

PI_NAMEs: ASHLEY, EUAN A;KOHANE, ISAAC S. (contact);MARTH, GABOR T;MIGHT, MATTHEW BRENDON;TAYLOR, HERMAN ALFRED;WARNER, BARBARA B

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Address;advocacy organizations;Amalgam;Automation;Bioinformatics;Biomedical Research;Caring;Clinic;Clinical;clinical care;Clinical Research;Consent;Data;Data Analyses;Data Coordinating Center;data management;data science management;data sharing;design;Diagnosis;Diagnostic;Diagnostics Research;Disease;Ecosystem;Ensure;Environment;Etiology;Evaluation;experience;Family;follow-up;genome-wide;Genomics;Goals;Healthcare;Healthcare Systems;Industry Standard;Infrastructure;Institution;Knowledge;Lead;Machine Learning;Medical;medical schools;multidisciplinary;Nomenclature;novel diagnostics;outreach;Patient advocacy;Patient Participation;patient population;patient screening;Patient-Focused Outcomes;Patients;Persons;Process;Productivity;programs;rare condition;remediation;Research;Research Personnel;Research Support;response;scale up;Scheme;Science;Services;Therapeutic;timeline;Translational Research;United States National Institutes of Health

PROJECT_TITLE: Diagnosing the Unknown for Care and Advancing Science (DUCAS)


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Rare Diseases

PI_NAMEs: KOHANE, ISAAC S. (contact)

PROJECT_TERMS: Acceleration;Address;Area;Biomedical Research;Caring;Clinical;Clinical Data;Clinical Research;Collaborations;Data;Data Coordinating Center;data management;data sharing;design;Development;Diagnosis;Diagnostic;Disease;Education;Ensure;Evaluation;Evidence based practice;experience;Feedback;follow-up;Foundations;Future;Generations;genomic data;Genomics;Goals;improved;Infrastructure;innovation;Institution;Knowledge;Lead;Leadership;Medical;medical specialties;Methods;novel;operation;Outcome;Outcome Assessment;outreach;Patient Care;patient engagement;Patients;Phase;Process;process improvement;programs;Protocols documentation;Provider;Public Relations;rare condition;Rare Diseases;recruit;Reporting;Research;Research Support;Science;success;Technology;web platform;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Complementary and Integrative Health;Data Science;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: MARTH, GABOR T (contact)

PROJECT_TERMS: Acceleration;Adoption;Architecture;Archives;Artificial Intelligence;automated analysis;Automation;Benchmarking;candidate identification;Caring;clinically relevant;cohort;Collaborations;Collection;Common Data Element;Communication;Computer software;Consent;Data;Data Collection;Data Coordinating Center;data management;data quality;Data Reporting;data submission;database of Genotypes and Phenotypes;design;Diagnosis;Diagnostic;electric impedance;Electronic Health Record;empowerment;Engineering;Ensure;Environment;Environmental Exposure;Evaluation;exome sequencing;Family;Fast Healthcare Interoperability Resources;flexibility;gene discovery;Genetic;genome sequencing;genomic data;Genomics;Genotype;Human;improved;innovation;Machine Learning;Metadata;Monitor;multimodal data;Nature;non-genetic;novel;Online Systems;Ontology;operation;outreach;participant enrollment;Pathway Analysis;patient portal;Patient Self-Report;patient subsets;Patients;Phase;Phenotype;PhenX Toolkit;Population;Precision therapeutics;Problem Solving;Process;Provider;Readability;Records;Reporting;repository;Research;Research Personnel;Resolution;scale up;Science;Secure;Security;Service delivery model;Services;System;Therapeutic;Time;tool;transcriptome sequencing;Triage;United States Department of Veterans Affairs;Update;Variant;Visualization;web app;web page;web portal;web services

PROJECT_TITLE: Data Management Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Although Black Americans are twice as likely to have Alzheimer’s disease than White Americans, little is known about the impact of social and societal determinants of health on neurocognitive integrity of the medial temporal hippocampal memory and prefrontal-executive systems, the primary brain systems impacted in Alzheimer’s disease. The objective of this application is to investigate the impact of interpersonal and institutional/structural racism on neurocognitive integrity of these brain systems in Black adults aged 65 years and older and to examine cardiovascular disease risk as an underlying biological mechanism. Addressing this knowledge gap is critical for developing new health policies and biobehavioral and social interventions for healthy aging.

PI_NAMEs: SCHON, KARIN  (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Address;Adult;African American population;Age;Aging;aging brain;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Ambulatory Blood Pressure Monitoring;Ambulatory Monitoring;American;American Heart Association;Amygdaloid structure;Atherosclerosis;biobehavior;Biological;Biological Markers;Biometry;Black American;Black race;black women;Blood Pressure;Blood Tests;Brain;brain health;Cardiology;cardiovascular disorder risk;cardiovascular health;caucasian American;Chronic;Chronic stress;Cognitive;cognitive neuroscience;cognitive testing;college;community engagement;comorbidity;Data;depressive symptoms;Dimensions;Discrimination;Disparity;Education;Episodic memory;Equation;executive function;Exhibits;experience;Family;Family history of;Fasting;Future;Genetic Risk;geriatric mental health;Goals;Head;Health;health determinants;health disparity;health inequalities;Health Policy;healthy aging;Hippocampus;Human;human old age (65+);Hypersensitivity skin testing;Implicit Association Test;indexing;Inequity;Institution;Institutional Racism;Interview;Knowledge;Left;Life Stress;Link;Lipids;Magnetic Resonance Imaging;Measures;Medial;Mediating;Mediation;Mediator;Memory;Memory Loss;Mental Depression;Mental Health;Methods;Modeling;Nerve Degeneration;neural;Neurobiology;Neurocognitive;neuropathology;Neuropsychology;older adult;Outcome;Participant;perceived discrimination;physical conditioning;Population Heterogeneity;Positioning Attribute;predictive modeling;Prefrontal Cortex;Proxy;Race;racism;Recording of previous events;recruit;residential segregation;Risk Factors;sex;social;Social Discrimination;social factors;social interventions;social stress;Societal Factors;Socioeconomic Status;Source;Structural Racism;Structure;System;Testing;Thick;White Matter Hyperintensity

PROJECT_TITLE: Perceived racism, cardiovascular disease risk, and neurocognitive aging

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: CORNELIUS

ORG_NAME: PHASE, INC.

ORG_STATE: NC

PHR: Narrative Microfluidics (MF) are the test tubes of the digital age and play a vital role in drug discovery, biotechnology, lab- and organs-on-a-chip, personalized point-of-care diagnostics and treatment, disease research, and more. Phase, Inc. is developing a new 3D printing technology to create PDMS microfluidics that believe will fundamentally change the way PDMS microfluidics are fabricated and unlock the design freedom of additive manufacturing for the MF community, which will lead to significant advancements of in vitro MF models. This new 3D printing technology will allow researchers to quickly design and create microfluidic devices in a matter of hours – as opposed the weeks it now takes. This will enable researchers to more quickly test drugs to treat illness and decrease the time needed for new medicines to reach the market and, in turn, patients. Narrative

PI_NAMEs: SCHULTZ, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: CROUCHER, LEAH TOLOSA

PROJECT_TERMS: 3-Dimensional;3D Print;Adopted;Adoption;Age;Animal Model;Architecture;Basement membrane;Biological;biological systems;Biomanufacturing;Biotechnology;Blood - brain barrier anatomy;Cardiovascular Diseases;Cell Survival;Characteristics;Clinical Trials;Coculture Techniques;Collaborations;commercialization;Communities;design;Development;Devices;digital;Disease;drug discovery;drug testing;Electrical Resistance;Electrodes;Endothelium;Ensure;fabrication;Face;Familiarity;Formulation;Freedom;Growth;Hour;Human;human model;improved;In Vitro;in vitro Model;in vivo;Injections;innovation;kinetic model;Kinetics;knowledgebase;Lasers;Legal patent;Light;lithography;manufacture;manufacturing process;manufacturing technology;Marketing;Measurement;Mechanics;Medicine;Membrane;meter;Methods;Microfluidic Microchips;Microfluidics;Modeling;models and simulation;Molds;nanofiber;nanomembrane;novel therapeutics;organ on a chip;particle;Patients;Performance;Permeability;Pharmacologic Substance;Phase;Play;point-of-care diagnostics;polydimethylsiloxane;Polymers;Porosity;Printing;Process;Production;Reproducibility;Research;research and development;Research Personnel;Resolution;Rheology;Risk;Role;Sampling;Source;System;Technology;Testing;Thick;Tight Junctions;Time;tool;Toxic effect;Tube;Virginia

PROJECT_TITLE: ADDITIVE MANUFACTURING OF PDMS MICROFLUIDICS


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences

PI_NAMEs: COLE, FRANCIS SESSIONS (contact)

PROJECT_TERMS: Acceleration;Award;behavioral health;Benchmarking;Bioinformatics;Biological;Biological Models;Biology;Biomedical Research;Caring;Case Management;Clinical;Clinical Research;Clinical Trials;cohort;Collaborations;Computer Models;Consultations;Data;data access;Data Coordinating Center;Data Element;data management;data sharing;design;Diagnosis;Diagnostic;Disease;Ecosystem;Electronic Health Record;Ensure;Equity;Evaluation;experience;experimental study;Expert Opinion;Expert Systems;Family;Funding;Genes;genetic variant;Genomics;Geography;Goals;Health Promotion;Human Resources;Immunologics;Individual;Infrastructure;insight;Institution;International;Manuals;meetings;member;metabolomics;model organism;Modeling;Monitor;multiple omics;novel;operation;Pathogenicity;Patients;Performance;Phenotype;predictive modeling;Process;programs;Rare Diseases;Reporting;Research;Research Personnel;Research Project Grants;Research Proposals;Research Support;Review Committee;Schedule;Science;Site;Standardization;success;Therapeutic;Translational Research;United States National Institutes of Health;Update;variant of unknown significance;virtual;Work

PROJECT_TITLE: Clinical Research Support Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Prevention;Rare Diseases;Sepsis

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative The goal of this application is to investigate the contribution of relative adrenal insufficiency to sepsis. Accomplishment of this study will improve our understanding of sepsis and provide a “proof of concept” to support a precision medicine approach to direct the use of glucocorticoid for sepsis therapy.

PI_NAMEs: LI, XIANG-AN  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;Adrenal gland hypofunction;Adrenal Glands;Animal Model;biological adaptation to stress;Cessation of life;Corticotropin;Death Rate;Glucocorticoids;Goals;Health;high density lipoprotein receptor;improved;Knockout Mice;Laboratories;Modeling;Mus;Patients;precision medicine;Predisposition;Production;protective factors;Reporting;response;Risk Factors;Sepsis;septic;septic patients;Septic Shock;SR-BI receptor;Stress;Subgroup;Supplementation;translational study

PROJECT_TITLE: Relative adrenal insufficiency as a risk factor and an endotype for sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE The research proposed in this application is relevant to public health because chronic pancreatitis is a progressive, incurable inflammation that leads to permanent organ damage and cancer. The proposed work will define key roles for pancreatic immune messengers that control damaging inflammatory responses and use structure-based drug discovery approaches to disrupt disease progression and improve patient health.

PI_NAMEs: DWINELL, MICHAEL B;VOLKMAN, BRIAN F (contact)

PROGRAM_OFFICER_NAME: SERRANO, JOSE

PROJECT_TERMS: Animal Model;Binding;Biological Assay;Biology;Cell Migration Inhibition function;Cell model;cell motility;Cell Physiology;Cells;Chemicals;chemokine;chemokine receptor;Chemotaxis;Chronic;chronic pancreatitis;Data;design;Desmoplastic;Development;Disease;Disease Progression;drug discovery;Ductal Epithelial Cell;effector T cell;Elements;Epithelial Cells;Fibrosis;Functional disorder;G-Protein-Coupled Receptors;Goals;GPR2 gene;Health;high throughput screening;Hot Spot;Immune;Immune response;Immunotherapy;improved;in vitro Model;in vivo;Infiltration;Inflammation;Inflammatory Response;inhibitor;Kinetics;Knockout Mice;Knowledge;Ligands;Link;Malignant - descriptor;Malignant Neoplasms;Maps;Measures;Methods;Modeling;Molecular;molecular modeling;mouse model;Mucositis;Mucous Membrane;Neoplasms;Organ;overexpression;Pancreas;pancreas development;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;Pancreatitis;Patients;pharmacologic;Pharmacology;Physiological;Play;premalignant;programs;Protein Secretion;Public Health;Publishing;receptor;recruit;Regulatory T-Lymphocyte;Research;response;Risk Factors;Role;screening;Signal Transduction;Site;small molecule;small molecule inhibitor;Structural Models;Structure;T cell infiltration;Testing;Therapeutic;therapeutic target;Tissues;trafficking;tumor;tumor growth;Tumor Promotion;tyrosine O-sulfate;Work

PROJECT_TITLE: Structure-based inhibition of chemokine signaling in the inflamed pancreas

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: TUCSON

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Our overall goal of this project is to understand the role of social connection OUD-related recovery outcomes, specifically during the postpartum period. The results of this study, regardless of outcome, will directly contribute to scientific knowledge on the role of social connectedness in postpartum OUD recovery. Moreover, this work will allow for the identification of new intervention targets, which will contribute to the development of novel, high- impact relapse prevention treatments tailored to the perinatal period, a unique inflection point with ample untapped opportunity.

PI_NAMEs: ALLEN, ALICIA M (contact);LINDE-KRIEGER, LINNEA B

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Academic achievement;Anxiety;Behavioral;Birth;Buffers;care giving burden;caregiving;Child;Childbirth;Control Groups;craving;Data;Data Analytics;Development;Ecological momentary assessment;Elements;Emotional;Evidence based treatment;Family;foster care;fourth trimester;General Population;Generations;Goals;Health;high risk;illicit opioid;improved;Individual;individualized medicine;Infant;infant outcome;informant;Intervention;Interview;Knowledge;Loneliness;Machine Learning;Maternal Mortality;Medical Records;Mental Depression;Mothers;Motivation;novel;Opioid;opioid misuse;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose death;Pain;Pain management;Participant;Pattern;peer support;Perinatal;perinatal period;Play;Population;Postpartum Depression;Postpartum Period;Pregnancy;Prevalence;prevent;Prevention;Recovery;Recovery Support;Relapse;relapse prevention;relapse risk;Research Project Grants;Risk;Risk Factors;Role;Sampling;Signal Transduction;Sleep disturbances;social;social attachment;Social isolation;Social outcome;Social support;Specialist;statistics;Stress;stress management;stressor;Substance Use Disorder;Target Populations;Testing;Theoretical model;Time;Woman;Work

PROJECT_TITLE: Evaluating Social Connectedness to Support Recovery from Opioid Use Disorder during the Postpartum Period


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Over 6 million adults in the U.S. are living with Alzheimer's Disease and Alzheimer's Disease Related Dementias (ADRD), a population estimated to double by 2050. We propose to examine the effects of enrollment in private Medicare Advantage plans versus traditional Medicare on health care use, management of comorbid conditions, potentially inappropriate medication use, and stays in nursing homes for beneficiaries with Alzheimer's Disease and Alzheimer's Disease Related Dementias. Given growing enrollment in the Medicare Advantage program, the findings from this project will provide important evidence of the program's effect on the health of individuals with Alzheimer's Disease and Alzheimer's Disease Related Dementias.

PI_NAMEs: SHIER, VICTORIA  (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Adult;adverse drug reaction;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;beneficiary;care coordination;Caring;Characteristics;Chronic;Chronic Disease;Communities;comorbidity;Complex;cost;Cost Control;Data;Dementia;Disease Management;Drug Prescriptions;Enrollment;financial incentive;Geographic Locations;Growth;Health;Health Benefit;health care delivery;health care service utilization;health service use;Health Services;Health Status;Healthcare;Hospitalization;Hospitals;Impaired cognition;improved;Incentives;Individual;Inpatients;insight;Institutionalization;Knowledge;Long-Term Care;Medical;Medicare;meetings;Natural experiment;Nursing Homes;Outcome;Outpatients;Patient Self-Report;patient subsets;Patient-Focused Outcomes;payment;Persons;Pharmaceutical Preparations;Policy Maker;Polypharmacy;Population;Prevention;Preventive service;Privatization;programs;Quality of Care;Research;retiree;satisfaction;Services;social service provider;tool;treatment adherence;Variant;Visit;Vulnerable Populations

PROJECT_TITLE: The impact of Medicare Advantage on Health Care, Management of Comorbid Conditions, and Potentially Inappropriate Medication Use, for Beneficiaries with Alzheimer's Disease and Its Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-L(90)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cocaine;Drug Abuse (NIDA only);Neurosciences;Sleep Research;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative The progressive intensification of drug craving/seeking across periods of drug abstinence poses a significant challenge for avoiding relapse to drug use. In the proposed experiments, we will use sleep electrophysiology, neurochemistry, biochemistry, and viral approaches to examine the extent to which sleep disruptions during cocaine abstinence contribute to dopamine terminal adaptations and persistent seeking and motivation for cocaine. Completion of the proposed experiments will reveal whether normalizing sleep or dopamine transporter expression and function is sufficient to prevent seeking and motivation for cocaine.

PI_NAMEs: ESPAÑA, RODRIGO A. (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Abstinence;Animals;Architecture;Attention;Attenuated;Biochemistry;Brain;Chronic Disease;Clinical;Cocaine;cocaine related behaviors;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;comparative;Cues;Data;design;Development;Dopamine;dopamine transporter;dopaminergic neuron;drug abstinence;drug craving;Drug usage;Electrophysiology (science);experimental study;Exposure to;extracellular;Future;improved;Incubated;insight;knock-down;Link;Mediator;mesolimbic system;Molecular;Motivation;neurochemistry;neurotransmission;Nucleus Accumbens;Periodicity;Pharmaceutical Preparations;Pharmacotherapy;Phosphorylation;prevent;Procedures;Process;Psychological reinforcement;Publishing;Rattus;Recovery;Relapse;relapse prevention;relapse risk;REM Sleep;restoration;Scanning;Schedule;Sleep;sleep abnormalities;Sleep Architecture;Sleep disturbances;sleep regulation;Sleep Wake Cycle;Slice;Substance Use Disorder;Testing;Time;transmission process;treatment strategy;uptake;Ventral Tegmental Area;Viral

PROJECT_TITLE: Sleep Disturbances During Cocaine Abstinence, Dopamine Adaptations, and Motivation for Cocaine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-T(02)M]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative This proposal is a competing renewal that will build upon the research completed during the last funding cycle to extend resource preserving, outcome dependent and outcome related sampling designs to generalized ordinal and longitudinal response data. For this funding cycle we will focus on robustness by way of new classes / applications of semiparametric models and estimation procedures. While efficient study designs are ubiquitous medical and public health research, we seek to expand this important methodology, and tools for implementation, to generalized ordinal and longitudinal ordinal data settings.

PI_NAMEs: SCHILDCROUT, JONATHAN SCOTT (contact)

PROGRAM_OFFICER_NAME: WOLZ, MICHAEL

PROJECT_TERMS: Address;biobank;Biological Assay;Biometry;Blood;Budgets;case control;Categories;CD8B1 gene;Clinical;cohort;Cohort Studies;Complex;cost;COVID-19 severity;Data;Data Analyses;Data Collection;Data Coordinating Center;data modeling;Data Set;Data Sources;design;Electronic Health Record;electronic health record system;flexibility;Formulation;Funding;health care service utilization;health record;HIV;implementation tool;Knowledge;Linear Models;Link;Logit Models;longitudinal dataset;longitudinal design;Manuals;Measures;Medical;Medical History;member;Methodology;Modeling;Modernization;novel;opportunity cost;Outcome;Outcome Study;Participant;Phase;preservation;Procedures;programs;prospective;public health research;randomized, clinical trials;Relaxation;repository;Research;Research Design;Research Personnel;research study;Resource-limited setting;Resources;response;Role;Sample Size;Sampling;Sampling Biases;semiparametric;Sepsis;Severities;Statistical Models;Time;tool;Variant;Work

PROJECT_TITLE: Outcome Dependent Sampling of Longitudinal Data: Design and Analysis

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project The Narrative proposed robust, privacy-preserving distributed analysis platformwill enable cancer researchers to address data bias and disparities (due to missing data and other sources) by leveraging data from multiple institutions/entities with enhanced data privacy protection. It collaboration robustness limited will help lower regulatory and other hurdles in across multiple institutions and further enhance t he public trust. It will improve the validity, and generalizability of research findings, and offer substantial benefits in areas including, but not to, cancer disparities research and informatics practice.

PI_NAMEs: JIANG, XIAOQIAN ;LONG, QI  (contact)

PROGRAM_OFFICER_NAME: YU, MANDI

PROJECT_TERMS: Address;anti-cancer research;Architecture;Area;Biomedical Research;cancer care;cancer health disparity;care delivery;Client;Collaborations;Communities;Data;Data Correlations;data imputation;data privacy;data repository;Disparity;Electronic Health Record;encryption;Ensure;FAIR principles;Feedback;Geographic Locations;health data;health disparity;health inequalities;Health Policy;Health protection;Healthcare;improved;Individual;Informatics;innovation;Institution;Insurance;interest;Lead;Legal;machine learning model;Malignant Neoplasms;marginalization;Medicine;Methodology;Methods;Minority Groups;minority patient;Modeling;novel;open source;Patients;Pattern;Privacy;privacy preservation;privacy protection;Privatization;Process;public trust;Research;Research Personnel;research study;Risk;Sample Size;Sampling Biases;Secure;Security;Services;Source;statistical and machine learning;system architecture;Systems Analysis;tool;Training;underserved minority;usability;user-friendly;Work

PROJECT_TITLE: Robust privacy preserving distributed analysis platform for cancer research: addressing data bias and disparities


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Obesity causes chronic inflammation without any obvious infection or autoimmune diseases. This chronic inflammation predisposes obese patients to various metabolic disorders, such as insulin resistance, type 2 diabetes, and diabetic complications. However, the underlying causes of the sterile inflammation remains poorly understood. The proposed studies will determine the role of the ALCAT1 enzyme as a key regulator of inflammation and insulin resistance, thereby a novel drug target for obesity and metabolic diseases.

PI_NAMEs: SHI, YUGUANG  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Ablation;Acyl Coenzyme A;Acyltransferase;Adipocytes;Adipose tissue;age related;Attenuated;Autoimmune Diseases;Binding;Cardiolipins;CASP1 gene;Cell Aging;Chronic;Complications of Diabetes Mellitus;cytokine;Data;defense response;Development;diet-induced obesity;Disease;Docosahexaenoic Acids;Enzymes;Family;functional loss;Health;Host Defense;Human;in vivo;Infection;Infiltration;Inflammasome;Inflammation;Inflammatory;inhibitor;Insulin Resistance;Interleukin-1 beta;Link;Macrophage;Mammals;marenostrin;Mediating;Metabolic;Metabolic Diseases;Metabolic stress;microbial;misfolded protein;mitochondrial dysfunction;Molecular;Neurodegenerative Disorders;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;obese patients;Obesity;obesity treatment;oxidative damage;Oxidative Stress;Pathogenesis;Pathologic;Pathway interactions;polymerization;Polymers;Polyunsaturated Fatty Acids;prevent;prion-like;Prions;Production;Property;protein aggregation;Proteins;Reactive Oxygen Species;Reporter;response;Role;senescent cell;sensor;Shapes;Signal Transduction;Sterility;Stimulus;sup35;System;Testing;transmission process;Variant;Work;Yeasts

PROJECT_TITLE: Cellular mechanisms of NLRP3 activation by ALCAT1 in diet-induced obesity

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Radiation Oncology;Social Determinants of Health

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative The clinical and financial burden of cancer care in the United States is high and rising, but little is known about the variation in radiation oncology spending and quality across the country and characteristics of high-performing radiation oncology practices. This research proposal will assess the variation in spending, utilization, and quality of radiation oncology practices across the U.S., determine whether disparities in care are seen for dually eligible Medicare and Medicaid patients, and identify unique strategies of high-performing practices based on insights from physicians and other healthcare workers. This study is relevant to public health and could have significant implications for clinicians and patients as the radiation oncology alternative payment model looms and as policymakers continue to seek ways to improve the value of cancer care.

PI_NAMEs: LAM, MIRANDA  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Affect;Area;beneficiary;cancer care;cancer health disparity;Cancer Patient;cancer radiation therapy;cancer therapy;cancer type;care delivery;care providers;career development;Caring;Characteristics;chemotherapy;Clinical;cost;Country;Data;Development;disabled;Disparity;dual eligible;Educational process of instructing;Emergency department visit;Ensure;Evaluation;Financial Hardship;Future;Goals;health care disparity;Health Personnel;Health Policy;Healthcare;Hospitals;improved;Incentives;Inequity;informant;insight;interest;Interview;Leadership;Link;Low income;Malignant Neoplasms;Measures;Medicaid;Medicare;Medicare claim;Medicare/Medicaid;Methods;Modeling;older adult;Oncology;oncology service;Outcome;Patient Care;Patient-Focused Outcomes;Patients;payment;Physicians;Policies;Policy Maker;Policy Research;Population;Positioning Attribute;Privatization;programs;prospective;Provider;Public Health;Qualitative Methods;Quality of Care;radiation delivery;Radiation Oncologist;Radiation Oncology;Radiation therapy;Randomized;Research;Research Personnel;Research Proposals;safety net;Savings;Scientist;Shapes;success;System;Time;United States;United States Centers for Medicare and Medicaid Services;Variant;Vulnerable Populations

PROJECT_TITLE: Assessing Variation in Outcomes for Cancer Patients Receiving Radiation Treatments and Identifying High-Value Radiation Oncology Practices

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE: Disparities in the health care system are substantial, leading to worse health outcomes and quality of care for marginalized groups. The proposed research builds a framework for reducing health disparities by creating fairer algorithms and removing societal bias from health care data for multiple marginalized groups with rigorous testing in a high-impact chronic kidney disease study. The broad applicability of the framework and creation of reusable computational tools will facilitate deployment in many practical settings.

PI_NAMEs: ROSE, SHERRI  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: adaptive learning;Address;algorithm development;algorithmic bias;Algorithms;biomedical informatics;care coordination;Chronic Kidney Failure;clinical care;Communities;Comprehensive Health Care;computerized tools;Data;data registry;data resource;Data Science;Data Set;Data Sources;design;Development;Disparity;disparity reduction;Equilibrium;Equity;Ethics;ethnic diversity;ethnic health disparity;ethnic minority;Ethnic Population;experimental study;flexibility;Geography;Goals;Grant;Health;health care delivery;health care disparity;health care settings;health data;health disparity;health equity;health outcome disparity;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;improved;Individual;Inequity;innovation;insight;Institute of Medicine (U.S.);interest;Knowledge;Literature;marginalization;marginalized population;Measurement;Measures;Methodology;Methods;novel;open source;open source tool;Outcome;Patient Care;Performance;performance tests;Phase;poor health outcome;Population Heterogeneity;Primary Care;Process;process optimization;Public Health;Quality of Care;racial disparity;racial diversity;racial minority;racial population;racism;Reduce health disparities;Reproducibility;Research;rural area;Saran;simulation;social health determinants;socioeconomics;Specific qualifier value;statistical learning;Statistical Methods;synthetic data;Techniques;Testing;tool;treatment as usual;United States;United States National Library of Medicine;Work

PROJECT_TITLE: Novel Algorithmic Fairness Tools for Reducing Health Disparities in Primary Care

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

PHR: Public Health Relevance Maternal health in the US is in crisis, where quality of care and health outcomes are particularly concerning for low-income pregnant and postpartum women (PPW), the majority of whom are covered by Medicaid. Large scale, innovative Medicaid care delivery models like Accountable Care Organizations (ACOs) present an important opportunity for states to improve maternal health outcomes at scale through better care integration, coordination, and quality improvement incentives, although very limited evidence is available to guide states and policymakers. This research will therefore fill this critical evidence gap by evaluating how Medicaid ACOs, and different Medicaid ACO model designs, can improve quality of care for PPW by leveraging a novel natural experiment using both claims data and qualitative data.

PI_NAMEs: COLE, MEGAN B. (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Accountability;accountable care organization;Address;Affect;Age;Behavioral;Birth;Black race;care coordination;care outcomes;Caring;Clinical;Color;cost;Data;Death Rate;design;Developed Countries;Enrollment;Equity;Ethnic Origin;Ethnic Population;Exclusion;experience;financial incentive;Goals;Health;health care quality;health equity;Health system;Heterogeneity;Hispanic;improved;improved outcome;Incentives;Individual;innovation;Inpatients;interest;Interview;Leadership;Literature;Low income;Low Income Population;Managed Care;Managed Care Programs;Massachusetts;Maternal Health;Maternal Health Services;Maternal Mortality;Measures;Medicaid;Medical;medical specialties;Medicare;member;model design;Modeling;Natural experiment;novel;Organizational Models;Outcome;participant enrollment;Patients;payment;people of color;Persons;Play;Policies;Policy Maker;Population;Postpartum Period;Pregnancy;pregnant;Premature Birth;prenatal;Prenatal care;Primary Care Physician;primary care provider;Process;programs;Provider;Qualifying;Qualitative Methods;Quality of Care;Quasi-experiment;Race;racial population;Research;response;Role;Service delivery model;severe maternal morbidity;Shapes;Social Work;Specialist;State Interests;Structure;Subgroup;success;trend;Visit;Vulnerable Populations

PROJECT_TITLE: Improving Quality of Care for Low-Income Pregnant People through Medicaid Accountable Care Organizations: A Natural Experiment

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]