NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE (from Parent Grant) Latinos have the highest risk of acute lymphoblastic leukemia (ALL) in the United States, and inferior outcomes compared with non-Latino whites. In this study, we will leverage the unique evolutionary history of Native Americans to carry out a comprehensive study of the role of germline genetic variation in the increased risk of childhood ALL in Latinos. Our results will help to elucidate the causes of this significant ethnic disparity and to identify children most at risk of developing ALL.

PI_NAMEs: DE SMITH, ADAM  (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: Accounting;Acute Lymphocytic Leukemia;Address;Administrative Supplement;admixture mapping;Affect;Americas;anti-cancer research;Area;Award;California;case control;causal variant;Cesarean section;Cessation of life;Child;Childhood;Childhood Acute Lymphocytic Leukemia;Childhood Leukemia;Communication;Communities;community organizations;Community Outreach;County;Cytomegalovirus Infections;Data;Data Set;Disease;disorder prevention;Education;Educational Materials;Ensure;Epidemiology;epidemiology study;ethnic disparity;Ethnic Origin;Ethnic Population;Etiology;European;Exhibits;Face;Funding;Future;Genetic;genetic association;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;Genotype;Germ Lines;Grant;Guatemala;health disparity;high risk;Hispanic;Hispanic Populations;Human;Immune;Immune response;Immunological Models;in utero;Incidence;Indigenous American;Individual;Infection;Inferior;insight;Intervention;Investigation;Latin American;Latino;Latino Population;Linguistics;Malignant Childhood Neoplasm;Meta-Analysis;Mexico;Modeling;modifiable risk;Morbidity - disease rate;Native American Ancestry;Native Americans;Natural Selections;Nature;non-genetic;novel;Outcome;parent grant;Parents;Patient Self-Report;Patients;Pediatric Oncology Group;Persons;Phenotype;Play;polygenic risk score;Population;Prevention;racial population;Recording of previous events;Reporting;Research;Risk;Risk Factors;risk variant;Role;Saint Jude Children's Research Hospital;Sample Size;SNP genotyping;social media;Survivors;Testing;Texas;tool;transcriptome;Trees;trend;United States;Variant;Work

PROJECT_TITLE: Understanding the increased risk of childhood acute lymphoblastic leukemia in Latinos

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Pediatric;Social Determinants of Health

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: VETERINARY SCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE Wildfire smoke has become a major source of particulate matter under 2.5 microns diameter (PM2.5) emissions and is expected to increase in the future because of climate change. Although the effects of ambient wildfire smoke inhalation on the development of chronic disease are largely unknown, toxic plumes resulting from the combustion of building materials, vehicles, and electronics in conjunction with biomass burning are likely to be a significant threat to human health. The goal of this R21 application is to investigate a potential mechanism for lung cellular toxicity resulting from ambient wildfire smoke exposure, which ultimately may lead to the identification of biomarkers and preventative measures to protect human health, particularly in vulnerable populations.

PI_NAMEs: MILLER, LISA A (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Age;Air Pollutants;Air Pollution;airway epithelium;alveolar epithelium;Animals;anthropogenesis;Asthma;biomarker development;biomarker identification;Biomass;building materials;California;Cell Culture Techniques;cell injury;Cells;Child;Childhood;Chronic Disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Chronology;climate change;County;cytokine;Data;defined contribution;Development;Diameter;Distal;early life exposure;Electronics;endoplasmic reticulum stress;Environmental Exposure;Epidemiology;Epithelial Cells;Epithelium;Event;Exploratory/Developmental Grant;Exposure to;Fire - disasters;Future;Goals;Growth;Health;high reward;high risk;Human;Immune;Immune system;in vivo;Infant;Inflammation;Inflammatory;Inflammatory Response;Inhalation;Injury;Knowledge;Life;Lipopolysaccharides;Lung;Lung Diseases;lung injury;Macaca mulatta;mature animal;Measures;mouse model;National Oceanic and Atmospheric Administration;Natural Immunity;neonatal exposure;Neonatal lung;neonatal mice;Organoids;Outcome;particle;particle exposure;Particulate Matter;Pathology;Persons;Physiology;Population;postnatal development;Predisposition;Preventive measure;Public Health;pulmonary function;Pulmonary Surfactant-Associated Protein C;Research;respiratory;Respiratory System;Risk;Smoke;smoke inhalation;Source;Testing;Toxic effect;Toxicology;Tracheobronchial;United States;United States Environmental Protection Agency;Upper respiratory tract;Vulnerable Populations;Wildfire;wood smoke

PROJECT_TITLE: Impact of Wildfire Smoke on Lung Injury

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Uveitis results in significant economic burden worldwide and can lead to long-term vision impairment. Main challenges have been the lack of adequate diagnostics and mechanistic understanding of the underlying uveitis entities. This project takes advantage of recent advances in genomic and programmable phage display technologies to identify important autoantigen and autoantibody profiles to address those gaps with the overall goal of improving patient visual outcomes.

PI_NAMEs: ACHARYA, NISHA ;DOAN, THUY A (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Address;Adult;Affect;Age;Animals;Anterior uveitis;Antibodies;Antibody Repertoire;Aqueous Humor;Area;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Bacteriophage T7;Bacteriophages;Biological Assay;biomarker discovery;Blindness;Classification;Clinical;Consumption;cost;Coupled;Detection;Diagnosis;Diagnostic;diagnostic strategy;Differential Diagnosis;Disease;Economic Burden;Enzyme-Linked Immunosorbent Assay;Epitopes;Etiology;experimental study;Eye;Future;Genomics;Goals;Health;High-Throughput Nucleotide Sequencing;Human;Immune response;Immune system;Immunofluorescence Immunologic;Immunosuppression;improved;improved outcome;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Laboratories;Libraries;Methods;Morbidity - disease rate;Motivation;noninvasive diagnosis;novel diagnostics;novel strategies;Oligonucleotides;Outcome;pathogen;Pathology;Patient Care;patient population;patient subsets;Patients;Peptide Library;Peptides;Phage Display;Phage ImmunoPrecipitation Sequencing;Plasma;Process;Proteins;Proteome;rational design;Recording of previous events;response;Sampling;Serology;Serology test;Specimen;Strategic Planning;Surveys;Technology;Testing;Therapeutic;therapy outcome;Time;Undifferentiated;Uveitis;Viral;Viral Antibodies;Viral Proteins;Virus Diseases;Visual;Visual impairment;Western Blotting

PROJECT_TITLE: Programmable Phage Display Peptidomes to Characterize Uveitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Our lab is dedicated to the mechanistic understanding of macromolecular function through the visualization of structure, dynamics, and regulatory interactions using cryo-EM, complemented with biochemical and biophysical assays. Our areas of study are centered on the characterization of the regulatory molecular mechanisms governing the function of microtubules and of human transcription/epigenetic complexes.

PI_NAMEs: NOGALES, EVA  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Acetylation;analog;Area;beta Tubulin;Binding;Biochemical;Biological Assay;Biophysics;Cell Differentiation process;Cell Nucleus;Cells;cellular development;Chromatin;chromatin remodeling;cofactor;Complex;Coupling;Cryoelectron Microscopy;Dedications;dimer;Dinucleosome;DNA;Epigenetic Process;Eukaryotic Cell;Funding;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Growth;Guanosine Triphosphate;Health;Histone H3;histone modification;HTATIP gene;Human;Hydrolysis;Knowledge;Lysine;Methylation;Microtubules;Molecular;Molecular Conformation;mutant;Nucleosomes;Phase;Polycomb;Polymers;PRC1 Protein;Process;promoter;Property;Regulation;RNA;RNA Polymerase II;Role;SAGA;Structure;System;TAF1 gene;Techniques;tool;Transcription Coactivator;Transcription Factor TFIIA;Transcription Factor TFIIB;transcription factor TFIIE;transcription factor TFIIF;transcription factor TFIIH;Transcriptional Regulation;Tubulin;Visualization;Work;Yeasts

PROJECT_TITLE: Structural studies of function and regulation of microtubules and transcriptional gene expression machinery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Mexican American older adults are expected to demonstrate the largest increase in dementia cases over the next 20 years, but little is known about the specific environmental, biological, individual, and sociocultural factors contributing to this risk. While participation in physical, cognitive, and social activities has been shown to influence the likelihood of developing dementia, the reliance on self-report questionnaires to assess these outcomes has prevented the development of specific recommendations regarding the necessary type, amount, and length of activity. We now propose to evaluate real-world physical, cognitive, and social activity patterns in Mexican American older adults using a validated digital technology platform to provide insights into targeted dementia prevention within this high-risk, underserved demographic.

PI_NAMEs: BEATTIE, ZACHARY ;GONZALES, MITZI MICHELLE (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Acculturation;Adopted;Adult;affective disturbance;Age;Aging;aging brain;Algorithms;Alzheimer's disease related dementia;American;Apolipoproteins;Atrophic;Attenuated;Behavioral;Biological;Blood;burden of illness;C-reactive protein;Cardiovascular system;Cellular Phone;Chitinase;Cognition;Cognitive;cognitive benefits;cohort;Collection;comorbidity;Computers;Coupled;Data;Dementia;dementia risk;density;Development;Devices;Diabetes Mellitus;digital;digital technology;Dimensions;Enrollment;ethnic minority;Ethnic Population;Evaluation;fitness;follow-up;Frequencies;Funding;Genetic;Genetic Load;Glial Fibrillary Acidic Protein;Health;health determinants;health organization;Health Sciences;high risk;hippocampal atrophy;Hispanic Populations;Home;Impaired cognition;indexing;Individual;Inflammation;Inflammatory;Injury;innovation;insight;Interleukin-6;Investigation;Length;lifestyle factors;low socioeconomic status;Machine Learning;Measurement;Measures;Memory;Mental Depression;Mexican;Mexican Americans;modifiable risk;Monitor;monitoring device;motion sensor;multimodal data;Neurodegenerative Disorders;neuroimaging;neuroinflammation;Not Hispanic or Latino;novel;Obesity;older adult;Oregon;Outcome;Outcome Assessment;Pathway interactions;Patient Self-Report;Pattern;Peripheral;Population;Population Study;Prevalence;prevent;Prevention;Prevention strategy;protective effect;Proteins;Questionnaires;racial minority;Recommendation;Research;resilience;resilience factor;response;Risk;Risk Factors;Science;sex;Shapes;social;Social Desirability;social engagement;sociocultural determinant;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Tablets;Technology;technology platform;Texas;Time;TNF gene;Travel;treatment strategy;Underrepresented Populations;United States;United States National Institutes of Health;Universities;wearable device;Weather;White Matter Hyperintensity

PROJECT_TITLE: Characterizing Older Mexican (American) Participation in Activity Digitally, Reliably, and Ecologically with the CART Platform (COMPADRE CART): Implications for Cognition and ADRD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(90)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HONOLULU

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE In August 2023, the deadliest wildfire in United States history incinerated the historical town of Lāhainā in Maui, Hawai‘i, which caused significant physical, mental, and environmental health problems that have strained the island’s already fragile health, social, and emergency systems. This study will use community engagement, interviews, focus groups, a survey, and analysis of administrative data to understand how the experiences and perceptions of residents, responders, and other frontline stakeholders have shaped Maui’s disaster-related (1) preparedness, response, and recovery; (2) individual, community, and health, social, and emergency system resilience, and (3) population health outcomes.

PI_NAMEs: KAHOLOKULA, JOSEPH KEAWE'AIMOKU;ORTEGA, ALEXANDER N (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Accelerated Executive Review;Address;Affect;Age;air contaminant;Award;barrier to care;Chemicals;Classification;Climate;climate crisis;Clinic;Communication;Communities;community advisory board;community engagement;community organizations;community-level factor;Data;Diagnosis;Disasters;Economics;Emergency Health Services;Emergency medical service;Emergency response;Emergency Situation;Environmental Health;Ethnic Origin;Event;experience;Exposure to;Failure;Family;Filipino;Fire - disasters;first responder;Focus Groups;Funding Mechanisms;Funding Opportunities;Future;Government;Government Agencies;Hawaii;Health;health care availability;health care service utilization;Health Disparities Research;health inequalities;Health Personnel;Health Services;Health Services Accessibility;Health system;Household;Incineration;Indigenous;Individual;Industry;Inpatients;Institution;Interview;Island;Latino;Learning;Living Costs;Medicaid;Medicaid eligibility;Mental Health;Mental Health Services;Methods;Minority Groups;National Institute on Minority Health and Health Disparities;Native Hawaiian or Other Pacific Islander;Natural Disasters;Outcome;Outpatients;Patients;Pattern;Perception;Persons;Pharmacy facility;Phase;physical conditioning;physical health service;Policies;Population;population health;Procedures;Process;Provider;Public Health;Qualitative Methods;Readiness;Recording of previous events;Recovery;Reporting;Research Support;residence;resilience;Resources;Respiratory Disease;response;Risk;Schools;service organization;Shapes;social;social determinants;social factors;social health determinants;Social Work;Surveys;Survivors;System;system-level barriers;Testing;Time;Trauma;United States;Visit;Water;Water Pollutants;Wildfire;Work

PROJECT_TITLE: Population Health and Health System Resiliency Following Maui's Wildfire Disaster

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-H (57)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: IRVINE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Cancer incidence is expected to increase to 23.6 million by 2030 worldwide, and cancer is the leading cause of death for Asian Americans whose numbers are rapidly rising to reach 40 million by 2050. Despite instances of greater cancer-specific mortality compared to other Asians and likely limited access to high- quality care due many experiencing language barriers (~50%), very little is known about supportive care needs in Chinese-, Vietnamese-, and Korean-Americans with metastatic cancers. This project will fill a critical gap in our understanding, and develop culturally relevant psychosocial resources/interventions aimed at improving the quality of life of Asian Americans with metastatic cancers.

PI_NAMEs: KIM, JACQUELINE H. J. (contact)

PROGRAM_OFFICER_NAME: ACEVEDO, AMANDA MARIE

PROJECT_TERMS: active method;Adult;Advocacy;Agreement;American;Asian;Asian Americans;Asian population;Behavioral;California;cancer care;Cancer Control;Cancer Etiology;Cancer Patient;cancer survival;care delivery;care outcomes;Caregivers;Caring;Cause of Death;Chinese;Collaborations;Communication;community advisory board;Competence;coping;cultural values;Data;demographics;design;Development;Diagnosis;Disease;Disseminated Malignant Neoplasm;Early Diagnosis;East Asian;Emotions;Ethnic Population;Exercise;experience;Faculty;Family;Feedback;Focus Groups;Fostering;Functional impairment;Future;Goals;Guidelines;Health Professional;Hispanic;Immigrant;improved;improved outcome;Incidence;informant;innovation;Intervention;Interview;Interviewer;Knowledge;Korean American;Koreans;Language;Latinx;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Medical;Mentorship;Methods;Modality;mortality;Not Hispanic or Latino;Oncology;Outcome;Participant;Patient Outcomes Assessments;Patients;Persons;Phase;Philosophy;Population;Positioning Attribute;preference;Process;psychosocial;psychosocial resources;Qualifying;Quality of Care;Quality of life;Randomized, Controlled Trials;Reporting;Research;Research Methodology;Research Personnel;Resources;skills;social;Social Environment;southeast Asian;Structure;Supportive care;Surface;Surveys;Survival Rate;survivorship;Symptoms;Testing;therapy design;therapy development;Training;Vietnamese;Work

PROJECT_TITLE: Supportive Care Needs in Asian Americans with Metastatic Cancer


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: Spinal cord injuries (SCI) and related disorders affect over 300,000 Americans, and the VA treats over 27,000 veterans with SCI every year. After SCI, rapid bone loss in the lower limbs greatly increases bone fragility and fracture risk. Current strategies to reduce post-SCI bone loss have shown limited success, thus novel approaches are needed. Irisin is a hormonal factor released from active muscle with potent effects on bone formation. Though irisin has been shown to prevent or reverse bone loss in animals, the relationship between irisin and bone health in humans with SCI is largely unknown. Determining whether factors related to irisin release are impaired by SCI, establishing a relationship between irisin and lower limb bone health, and identifying viable methods to effectively increase circulating irisin through exercise, could improve musculoskeletal rehabilitation strategies to combat post-SCI bone loss.

PI_NAMEs: STERCZALA, ADAM J (contact)

PROJECT_TERMS: Acute;Affect;Age;American;Animal Experimentation;Animals;arm;Attenuated;attenuation;Biomechanics;Biopsy;Blood specimen;bone;Bone Density;bone fragility;Bone Growth;bone health;bone loss;cardiometabolism;combat;comparison control;cortical bone;demineralization;design;Disease;Distal;Endocrine;Enzyme-Linked Immunosorbent Assay;Exercise;exercise intensity;exercise physiologist;exercise prescription;experience;Failure;Fast-Twitch Muscle Fibers;Femur;Fiber;Fibronectins;Finite Element Analysis;Fracture;fracture risk;Functional disorder;functional electrical stimulation;Gene Expression;Goals;Health;Homeostasis;Hormonal;Human;Impairment;improved;Individual;Injections;innovation;Intervention;intraperitoneal;K-Series Research Career Programs;Lesion;Lower Extremity;male;Mass Spectrum Analysis;Measures;mechanical load;Mediating;Mentorship;Metaphysis;Methods;Modality;mode of exercise;Muscle;Muscle Fibers;Musculoskeletal;Myosin Heavy Chains;Myosin S-1;novel;novel strategies;osteoblast differentiation;Osteoclasts;Osteogenesis;osteogenic;Paralysed;Performance;Peripheral;Polymerase Chain Reaction;Porosity;prevent;Property;Proteins;Quality of life;rehabilitation strategy;Rehabilitation therapy;release factor;Research;Resolution;response;Rest;Reverse Transcription;Scanning;Scientist;Signal Transduction;Skeletal bone;Skeletal Muscle;Spinal cord injury;substantia spongiosa;success;Techniques;Therapeutic;tibia;tomography;Training;Training Activity;vastus lateralis;Veterans;Weight-Bearing state;Western Blotting;Work

PROJECT_TITLE: The influence of irisin/FNDC5 on bone mineral density and fracture risk in individuals with spinal cord injury

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: Women Veterans are a fast growing population in VA and one that has healthcare needs distinct from the rest of the predominantly male population. In order to provide high-quality care for women, the VA has developed a specific program for women’s healthcare which includes designated women’s health providers and separate clinic structures for women. While the quality of women’s health care in VA has improved significantly in the last few decades, barriers to optimal care exist. Specifically, women Veterans face obstacles to receiving health care due to disproportionate caregiver responsibilities, work-life balance issues, and exposure to discrimination such as stranger harassment on VA grounds. Providing women Veterans the opportunity to use virtual care for the right health care concerns at the right time could create new ways for women to access timely needed care. This project seeks to create a package of approaches to improving when and how virtual care is offered to women Veterans.

PI_NAMEs: GIERISCH, JENNIFER MARIE;GOLDSTEIN, KAREN M. (contact)

PROJECT_TERMS: Acceleration;Address;Adoption;Age;Area;black women;burden of chronic illness;care delivery;care providers;career life balance;Caregivers;Caring;Client satisfaction;Clinic;Clinical;Communication;Communities;Comprehensive Health Care;Congresses;connected care;COVID-19 pandemic;Data;Data Collection;design;digital platform;Discrimination;Effectiveness;Emergency Situation;equity, diversity, and inclusion;ethnic diversity;Evaluation;evidence base;experience;Exposure to;Face;field study;Goals;harassment;Health;health care delivery;Health care facility;health care service;health disparity;health equity;Health Personnel;Healthcare;Household Heads;implementation outcomes;implementation strategy;improved;Infrastructure;innovation;Interview;Literature;male;Maps;marginalization;men;Menopause;Methodology;Methods;military veteran;Modality;Modeling;novel;online resource;operation;Outcome;pandemic disease;Patient Care;patient engagement;patient oriented;Patient-Centered Care;patient-clinician communication;Patients;Peer Review;Persons;Population;Positioning Attribute;post-COVID-19;post-pandemic;practice-based research network;pre-pandemic;Preventive;primary care team;Procedures;programs;Provider;Quality of Care;racial diversity;Reporting;Reproductive Health;Research;Resistance;Resources;Rest;Review Literature;Rural;Rural Health;satisfaction;Science;Services;Source;Structure;telehealth;Telephone;Time;Translating;Uncertainty;Veterans;virtual;virtual delivery;virtual healthcare;Woman;Women's Health;Women's Health Services;women's outcomes;Women's Rights;Work

PROJECT_TITLE: CompreHEnsive ViRtual Care for WOmen VEteranS (HEROES)

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Immunotherapy;Liver Cancer;Liver Disease;Precision Medicine;Rare Diseases

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Hepatocellular carcinoma (HCC) is increasing in incidence due to the sequalae of chronic liver disease, with no significant recent improvement in patient survival due to a lack of biomarker-driven therapeutics. ꞵ-catenin- activation (mutated CTNNB1 oncogene) represents a molecular subset of HCC cases which are resistant to current immunotherapies. This proposal will investigate mechanisms of ꞵ-catenin activation driving immunosuppression in the tumor immune microenvironment, with our results paving the way for precision medicine therapeutics for ꞵ-catenin-mutated HCC.

PI_NAMEs: LEHRICH, BRANDON  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: adaptive immune response;anti-PD1 therapy;Antigen Presentation;Automobile Driving;Award;BAY 54-9085;beta catenin;Binding;Bioinformatics;Biological Response Modifiers;biomarker driven;Cancer Biology;Cancer Etiology;career;Cell Proliferation;cell type;Cells;chronic liver disease;Clinical;clinically relevant;combinatorial;Combined Modality Therapy;CTNNB1 gene;Data;Development;differential expression;Disease;driver mutation;Education;end stage disease;Exclusion;Future;Gene Expression;Genes;Growth;Immune;Immune checkpoint inhibitor;Immune response;Immune System Diseases;Immune Targeting;Immunohistochemistry;Immunooncology;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Incidence;Inflammatory Response;inhibitor;Injections;Interferon Regulatory Factor 2;K-Series Research Career Programs;Knock-out;Lead;Link;Liver;liver cancer model;Lymphocyte;Lymphocyte Activation;Lymphocyte Function;Lymphoid;Malignant neoplasm of liver;Malignant Neoplasms;MET gene;Modality;Modeling;molecular subtypes;Monitor;mortality;mouse model;mutant;mutant mouse model;Mutate;neoplastic cell;novel;nuclear factor-erythroid 2;objective response rate;Oncogenes;Patients;Phenotype;Physicians;Population;precision medicine;Predisposition;Primary carcinoma of the liver cells;Proto-Oncogenes;Receptor Protein-Tyrosine Kinases;Regimen;Regulation;Repression;Research Training;Residencies;Resistance;response;response biomarker;Role;Scientist;Signal Transduction;single-cell RNA sequencing;Sleeping Beauty;standard of care;Survival Rate;synergism;synthetic biology;System;Tail;Techniques;Testing;Therapeutic;Therapeutic Effect;Training;transcription factor;Transposase;treatment stratification;tumor;Tumor Burden;Tumor Immunity;tumor-immune system interactions;Tumor-infiltrating immune cells;tumorigenesis;United States;Unresectable;Veins

PROJECT_TITLE: Investigating Immunosuppression in Beta-catenin-mutated Hepatocellular Carcinoma for Improved Precision Medicine Therapeutics


NIH_SPENDING_CATS: Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative Compared to European American (EA) men, African American/Black (AA/B) men have a 4x higher risk of metastatic prostate cancer (PCa) and 2-3x higher death rate from the disease. To identify which individuals are at the highest risk of developing aggressive PCa, we developed an adductomics approach to measure markers that are produced from altered metabolism and inflammation. We are now working to develop a multicomponent framework to determine the risk of PCa onset and progression in AA/B and EA men and to identify the important cellular components in this process.

PI_NAMEs: SHUCK, SARAH C. (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Acclimatization;adduct;Advanced Glycosylation End Products;African American;Aging;Algorithms;American;Androgen Receptor;Apoptosis;Area;Automobile Driving;Base Excision Repairs;Base Pairing;Binding;Biological;Biological Assay;Biological Markers;Biological Sciences;black men;Black race;Breast Cancer cell line;cancer cell;Cancer Cell Growth;Cancer Etiology;cancer health disparity;Carcinogens;case control;cell growth;Cell Line;Cells;cellular transduction;Cessation of life;Cities;Clinical;Clonal Expansion;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collaborations;Complementary DNA;Computer software;control trial;CRISPR/Cas technology;Culture Media;Data;Databases;de novo mutation;Deamination;Death Rate;design;Diabetes Mellitus;diabetogenic;Diagnostic tests;Disease;Disparity;DNA;DNA Adducts;DNA Damage;DNA Library;DNA Repair;DNA Repair Pathway;DNA Sequence Alteration;DNA Sequencing Facility;Dose;Drops;Drug Metabolic Detoxication;Engineering;Ensure;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;Epithelium;Etiology;European;Event;exome sequencing;experience;Exposure to;extracellular;Fatty acid glycerol esters;Frequencies;gene discovery;Gene Expression;Gene Frequency;Generations;Genes;Genetic;Genetic Polymorphism;Genetic Risk;Genetic Transcription;Genomic DNA;Genomic Instability;Genomics;Gentian Violet;Germ-Line Mutation;Glucose;Goals;Growth;Guide RNA;Harvest;high risk;Human;Human Genome;Hyperglycemia;In Vitro;in vitro activity;Incidence;Individual;Induced Mutation;Inflammation;Investigation;knock-down;Knock-out;Lactoylglutathione Lyase;Lead;Libraries;Lipids;LNCaP;Malignant neoplasm of prostate;man;Mass Spectrum Analysis;Measures;Medical Genetics;MEKs;men;Mentors;Messenger RNA;Metabolic;Metabolism;Metastatic Prostate Cancer;meter;Methods;Minor;Mismatch Repair;Modeling;Modification;Molecular;Morphology;mortality risk;mRNA Expression;Mus;Mutagenesis;mutant;Mutation;mutation assay;mutation screening;MYC gene;nano;non-diabetic;novel;nuclease;Nucleosides;Nucleotide Excision Repair;Nucleotides;Obesity;Outcome;Oxidative Stress;parent grant;Pathway interactions;Phase;Physiological;Population;Prediabetes syndrome;predictive test;prevent;Process;Production;Proliferating;prostate cancer cell;prostate cancer cell line;prostate cancer metastasis;prostate cancer progression;prostate cancer risk;protein expression;Proteins;Proteomics;Pyruvaldehyde;qubit;racial difference;racial disparity;racial diversity;racial population;RAS genes;Reactive Oxygen Species;receptor for advanced glycation endproducts;repaired;Reporting;Research Activity;Research Design;Research Personnel;Resistance;response;Risk;risk prediction;RNA;RNA Sequences;RNA Stability;RNA-Directed DNA Polymerase;Role;Sampling;Serum;Single Nucleotide Polymorphism;single-cell RNA sequencing;Site;socioeconomics;Solid;Sorting;Spectrophotometry;Stains;sugar;System;T-Lymphocyte;Testing;Therapeutic;Thioguanine;Time;Transcription-Coupled Repair;transition mutation;Translations;tumor;Untranslated RNA;Western Blotting;Whole Blood;Work

PROJECT_TITLE: Identification of metabolic adducts associated with prostate cancer progression in African American men Supplement


ADMINISTERING_IC: MH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Depression;Heart Disease;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Overall NARRATIVE. Women are at twice the risk of the co-occurrence of depression and autonomic dysregulation, which is associated with a 3-5-fold risk of death from heart disease later in life, often with unrecognized and untreated depression. This SCORE will conduct a set of basic science and clinical studies that are synergistic for understanding the risk for sex differences in depression and associated health outcomes over the lifespan. We will identify pathways that will lead to translation into sex-selective therapeutics and will train the next generation to incorporate knowledge of sex differences into how we think about and treat disorders of the brain and their impact on general medicine.

PI_NAMEs: GOLDSTEIN, JILL M (contact);TOBET, STUART A.

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: Adult Children;Amygdaloid structure;Anterior;Anxiety;Area;Attenuated;Autonomic Dysfunction;Autonomic nervous system;Basic Science;biological adaptation to stress;Biological Markers;Brain;brain circuitry;Brain Diseases;Brain imaging;Cardiac;Cardiovascular Diseases;career;Centers of Research Excellence;cingulate cortex;Clinical;clinical effect;Clinical Investigator;Clinical Research;Collaborations;Communities;comorbidity;Corticotropin-Releasing Hormone;Coupled;CRH gene;Cytokine Receptors;Data Analytics;depressive symptoms;Development;Devices;disability;Disease;early detection biomarkers;Early Intervention;effective therapy;Faculty;Fetal Development;Functional disorder;Genes;Glucocorticoid Receptor;Gonadal Steroid Hormones;Health;Heart Diseases;heart function;high risk;Hippocampus;Hormone secretion;Hormones;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Immune;immune function;Immune response;in utero;Interleukin-6;Knowledge;late life;Leadership;Life;life span;Major Depressive Disorder;Maps;Medical;Medicine;men;Mental Depression;middle age;Mission;Moods;mortality risk;Myocardial Ischemia;Nerve;Neuroanatomy;Neurons;neuroregulation;Neurosciences;neurovascular;next generation;novel therapeutics;Outcome;paraventricular nucleus;Pathway interactions;Peripheral;Physiological;Physiology;Policy Maker;Population;Prefrontal Cortex;prenatal;prenatal stress;Public Health;Receptor Activation;Recurrence;Resources;respiratory;response;Risk;Rodent Model;Scientist;Series;sex;Sex Differences;sexual dimorphism;Sexual Dysfunction;Specialized Center;Steroid Receptors;Stress;stress reactivity;Study models;success;Technical Expertise;Technology;Testing;Therapeutic;therapeutic development;TNF gene;Training;Translating;translational study;Translations;vagus nerve stimulation;Woman;Women's mortality

PROJECT_TITLE: Sex Differences in Major Depression: Impact of Prenatal Stress-Immune and Autonomic Dysregulation


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative Although thousands of nanoparticle engineering approaches have been developed, testing all of them in vivo requires a large amount of resources and time. Here, we adopt a nano-barcoding approach to study hundreds of nanoparticles directly in vivo, this study can accelerate the discovery of solid-tumor-targeting nanoparticle formulations.

PI_NAMEs: SCHMITTGEN, THOMAS D.;ZHANG, FAN  (contact)

PROGRAM_OFFICER_NAME: CLIFFORD, JOHN LEO

PROJECT_TERMS: Acceleration;Address;Adopted;Animals;Artificial Endocrine Pancreas;Artificial nanoparticles;Bar Codes;Behavior;Biodistribution;Biological Assay;Blood;Bone Marrow;Brain;Buffers;cancer cell;cancer therapy;cancer type;Carbon;Citrates;deep sequencing;Dendrimers;Development;DNA;DNA analysis;DNA sequencing;Early Intervention;Encapsulated;Epoxy Compounds;Ethanol;Exhibits;Fluorescence-Activated Cell Sorting;Formulation;Generations;Goals;Grant;high throughput screening;In Vitro;in vivo;indexing;Individual;Injections;interest;Intraperitoneal Injections;Lead;Libraries;light scattering;lipid nanoparticle;Lipids;Liquid substance;Liver;Lung;lymph nodes;Malignant neoplasm of pancreas;Measures;Mentors;Messenger RNA;MicroRNAs;Molecular;Mus;nano;nanoformulation;nanoparticle;novel;novel therapeutic intervention;Nucleic Acids;Oligonucleotides;Organ;Pancreas;Parents;Pathway interactions;Phase;phosphoethanolamine;Process;Reaction;Recovery;Research;Resources;Reverse Transcriptase Polymerase Chain Reaction;RNA delivery;screening;Screening Result;Site;Solid Neoplasm;Spleen;Testing;Therapeutic;Time;Tissues;Transfection;Translating;Tropism;tumor;tumor progression;Tumor Tissue;underrepresented minority student;zeta potential

PROJECT_TITLE: NCI Diversity Supplement


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Bioengineering;Brain Disorders;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: DAYTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WRIGHT STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This proposal is relevant to public health because ALS has few therapies with only modest benefits despite decades of research. Barriers arise from multifarious pathologies and conflicting literature, often due to inconsistent methods and unaccounted for biological variables. This project will develop advanced 3D quantitation of immunohistochemistry images to rigorously examine somatic morphology and potassium channel structure in normal vs. ALS motoneurons, to elucidate pilot data from the parent grant suggesting that Kv2.1 and SK contribute to functional changes in ALS.

PI_NAMEs: ELBASIOUNY, SHERIF M (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: 3-Dimensional;Algorithms;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Area;Biological;Brain;Calibration;Cell membrane;Cell Physiology;Cell Size;Cells;clinically relevant;Complex;Computer software;conflict resolution;Data;density;Disease;Electrophysiology (science);Exhibits;experimental study;Functional disorder;Glutamates;Height;Human;human error;Image;image processing;Immunohistochemistry;improved;Ion Channel;large datasets;Link;Literature;Manuals;Maps;Measurement;Measures;Membrane;Methodology;Methods;Morphology;Motor Neurons;Mus;neuronal cell body;novel;parent grant;Pathology;pharmacologic;Phosphorylation;Play;Potassium Channel;Process;Protein Dephosphorylation;Public Health;reconstruction;Reporting;Research;Resolution;Role;Sampling;Spinal;Structure;superoxide dismutase 1;Surface;Techniques;therapeutic target;three-dimensional visualization;Time;Visual;Width;Work

PROJECT_TITLE: 3D Immunohistochemistry analysis to enhance the rigor of motoneuronal somatic reconstruction and potassium channel characterization


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Social Determinants of Health

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative: The proposed studies will determine whether there are causal effects of exposure to air pollutants and temperature on mortality, heart attacks and strokes and whether those effects persist below current ambient standards. They will also identify whether there are interactions between the different exposures, whether some particle components are more toxic that others, and whether error in exposure estimates either prevents the identification of effects at low levels or biases effect estimates upwards. This will be done using state of the art mixture, causal modeling and measurement error methods, uniquely combining them for the first time.

PI_NAMEs: SCHWARTZ, JOEL D (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Acute;Address;Admission activity;Advisory Committees;Age;Air;Air Pollutants;Air Pollution;ambient air pollution;analytical method;Atrial Fibrillation;Attenuated;base;burden of illness;causal model;Censuses;Cessation of life;China;Chronic;climate variability;cohort;cost;Critiques;Data;Data Set;Death Certificates;Death Rate;design;Detection;Dose;epidemiology study;Equity;Event;experience;Exposure to;fine particles;Health;health disparity;Hospitalization;hospitalization rates;India;Individual;Joints;large datasets;Measurement;Measures;Medicaid;Medicare;Medicare/Medicaid;Methods;Modeling;Morbidity - disease rate;mortality;Myocardial Infarction;Nature;Neighborhoods;Nitrates;Nitrogen Dioxide;novel;Observational Study;Outcome;Ozone;Participant;particle;pollutant;Pollution;Population;prevent;Public Health;Quasi-experiment;Recommendation;Records;Resolution;response;Risk;Risk Estimate;Science;Scoring Method;simulation;Stroke;Subgroup;Sulfate;Techniques;Temperature;Time

PROJECT_TITLE: Identifying low dose measurement error corrected effects of multiple pollutants using causal modeling

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE The Midwest Microbial Pathogenesis Conference (MMPC) is a distinguished regional scientific meeting that promotes research at the intersection of disease and pathogenesis mechanisms. The focus of MMPC aligns with the mission of the National Institutes of Health to research the causes of diseases to improve human health and to develop fundamental and innovative scientific resources for the biomedical community. MMPC brings together hundreds of researchers with an emphasis on trainees and junior investigators to develop connections to nurture career development and research progress, all while fostering an environment of diversity, equity, and inclusion for the exchange of scientific ideas and collaborations.

PI_NAMEs: DALIA, ANKUR ;VAN KESSEL, JULIA C. (contact)

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TERMS: Address;Alabama;Applications Grants;Biological Sciences;biomedical resource;career development;Career Mobility;Cells;Collaborations;collaborative environment;Colorado;Communicable Diseases;Communities;COVID-19 pandemic;Dedications;Discipline;Disease;Ensure;Environment;equity, diversity, and inclusion;Exclusion;experience;Faculty;Feedback;Fees;Financial Support;Fostering;Funding;Future;Future Teacher;Geography;Goals;graduate student;Growth;Growth and Development function;Health;Human;human pathogen;Illinois;improved;Indiana;Influentials;innovation;Institution;Intervention;Invaded;Iowa;Kansas;Kentucky;Knowledge;Medical center;meetings;member;Mentors;Michigan;microbial;Microbiology;Midwestern United States;Minnesota;Mission;Missouri;National Institute of Allergy and Infectious Disease;New York;next generation;North Dakota;novel;Ohio;Oral;Participant;Pathogenesis;pathogenic bacteria;peer;Pennsylvania;Postdoctoral Fellow;posters;professor;Public Health;recruit;Recurrence;Research;research and development;Research Personnel;Role;role model;Science;Scientist;Series;Students;Surveys;symposium;Tennessee;Texas;Time;Travel;treatment strategy;undergraduate student;Underrepresented Populations;United States;United States National Academy of Sciences;United States National Institutes of Health;Universities;Utah;Washington;Wisconsin;Woman

PROJECT_TITLE: 30th Annual Midwest Microbial Pathogenesis Conference (MMPC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 CAB-D (M1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Clinical Research;Data Science;Dementia;Emergency Care;Health Services

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE:  This is a renewal of the Geriatric Emergency care Applied Research (GEAR 1.1) Network to grow its Ecosystem and infrastructure supporting transdisciplinary aging studies that advance emergency and dementia care research. We will expand the number of sites and data capabilities of GEAR, extend its breadth of claim and meta data with the NIA LINKAGE enclave, and conduct multicenter studies leveraging GEAR to address research gaps identified by priority populations.

PI_NAMEs: HWANG, ULA Y (contact);MEEKER, DANIELLA

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Acceleration;Accident and Emergency department;Accreditation;acute care;Address;Aging;aging population;Algorithms;Alzheimer's disease related dementia;Applied Research;Automobile Driving;biomedical informatics;Caring;Clinical Research;Collaborations;Communities;Continuity of Patient Care;Data;data ecosystem;data harmonization;data infrastructure;Data Linkages;data modeling;Data Science;Data Set;Data Sources;Databases;Decision Making;Dementia;dementia care;design;Detection;Development;Ecosystem;Effectiveness;Effectiveness of Interventions;Elderly;Electronic Health Record;Emergency Care;Emergency department visit;Emergency Department-based Intervention;Emergency Medicine;Emergency research;Emergency Situation;Environment;Evaluation;evidence base;Evolution;experience;Foundations;Funding;Future;Geriatrics;Goals;Growth;Guidelines;Health;health disparity;Health system;Healthcare Systems;Hospitals;implementation efforts;implementation science;Infrastructure;Integrated Health Care Systems;interest;Intervention;knowledge base;Learning;Link;longitudinal dataset;Longitudinal Surveys;Measures;Medical;Medicare;Medicare claim;Metadata;Modeling;mortality;Multi-Institutional Clinical Trial;Multicenter Studies;novel;Observational Study;older patient;Older Population;Outcome;Patient Care;Patients;Phase;Pilot Projects;Policies;Population;predictive tools;Procedures;programs;prospective;Protocols documentation;psychosocial;Reporting;repository;Request for Proposals;Research;Research Infrastructure;Research Personnel;Research Priority;research study;Science;Site;standard of care;Standardization;Structure;support network;Surveys;System;Techniques;Testing;tool;Typology;Waiting Lists;Work

PROJECT_TITLE: Growing the Geriatric Emergency care Applied Research (GEAR 1.1) network: Expanding and sustaining an emergency care aging study infrastructure.

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (M3)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: LOUISVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative. Taste disorders can have detrimental effects on a person's health and quality of life. The underlying mechanisms of these disorders are not understood but may result from disruption of the connections between taste buds and the neurons carrying taste information to the brain. Here, we are exploring the relationship between taste neuron structure, connectivity, and function to elucidate the role of connectivity in taste disorders.

PI_NAMEs: KRIMM, ROBIN FRANCES (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Adult;Anatomy;Axon;Brain;Brain-Derived Neurotrophic Factor;Calcium;cell type;cellular transduction;Characteristics;Chemicals;Citric Acid;Communication;Development;Disease;Epithelium;experimental study;Food;Functional Imaging;functional plasticity;Ganglia;Gene Expression;Genetic;Goals;Health;Hour;Image;in vivo;Individual;insight;intravital imaging;Intrinsic factor;Label;life span;Link;Measurement;Measures;Methods;Morphology;Mus;Nerve Fibers;Neurons;neurotrophic factor;overexpression;Pattern;Peripheral;Persons;Population;preproenkephalin;Process;proenkephalin;Quality of life;Receptor Cell;reconstruction;Regulation;Role;sensory system;Stimulus;Structure;Taste Bud Cell;Taste Buds;Taste Disorders;Taste Perception;taste stimuli;taste system;taste transduction;Temperature;Time;two photon microscopy;Variant;Wild Type Mouse

PROJECT_TITLE: Regulation of taste neuron morphology and function

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Hypertension;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Hypertension shortens life expectancy and increases the risk for cardiovascular disease and stroke. This project examines how social adversity or the chronic relegation to low social status may impact specific brain areas to induce sustained hypertension. We hypothesize that the disruption within a specific angiotensin sensitive neural circuit contributes to high blood pressure and may therefore be targeted to treat the disease

PI_NAMEs: DE KLOET, ANNETTE DIANE (contact);SUMNERS, COLIN

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Acute;Angiotensins;Anti-Hypertensive Agents;Area;Baroreflex;biological adaptation to stress;Blood Pressure;blood pressure elevation;blood pressure reduction;blood pressure regulation;Brain;Brain region;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cells;Central Nervous System;Characteristics;Chronic;Data;Development;Diagnosis;Disease;Functional disorder;Gene Transfer;Genetic;Glutamates;Homeostasis;Hypertension;hypertensive;Hypothalamic structure;Individual;insight;Life Expectancy;Liquid substance;Mediating;Modeling;mouse model;Mus;neural circuit;Neural Pathways;neural patterning;Neurons;Neurosecretory Systems;novel;novel strategies;novel therapeutics;Nucleus solitarius;optogenetics;Output;paraventricular nucleus;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;prevent;Publishing;Regulation;Resistant Hypertension;Role;social adversity;social defeat;Social status;social stress;Societies;Stress;Stroke;Testing;Therapeutic;Type 2 Angiotensin II Receptor;vasoconstriction;Vasopressins;Viral

PROJECT_TITLE: Angiotensin-sensitive neurons in the nucleus of the solitary tract mediate social stress induced hypertension

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Infectious Diseases

PHR: Project Narrative A recent outbreak of eye infections stemming from the use of contaminated bottles of artificial tears - these infections were caused by a particularly dangerous bacterium that is resistant to the antibiotics that clinicians generally use to treat eye infections. Unusually, these infections have spread beyond the eye resulting in death in some cases. The goal of this study is to learn more about how the bacteria causes infection and how to treat it.

PI_NAMEs: SHANKS, ROBERT M (contact)

PROJECT_TERMS: Animal Disease Models;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;antimicrobial;Artificial Tears;Bacteria;Bacterial Eye Infections;Bacterial Infections;Blindness;Cell Death;Cells;Cessation of life;clinically relevant;Collection;Combined Antibiotics;comparative genomics;Cornea;Cytolysins;cytotoxic;cytotoxicity;Dangerousness;Data;Development;Disease Outbreaks;Dose;Drug resistance;Drug resistant Pseudomonas aeruginosa;efficacy testing;Endophthalmitis;Equus caballus;Evaluation;experience;extensive drug resistance;Eye;Eye Infections;FDA approved;Formulation;Future;genome sequencing;Goals;Health;In Vitro;in vivo;Infection;Inflammatory Response;Invaded;Keratitis;Learning;Life;microbial;Modeling;Mus;Natural History;Oryctolagus cuniculus;Outcome;Pathogenesis;Pathogenicity;Patients;Penetration;Phenotype;Phylogenetic Analysis;Polymyxin B;Proliferating;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Reporting;Resistance;Resolution;Safety;Secondary to;Serratia marcescens;standard of care;stem;synergism;System;Systemic infection;Testing;Therapeutic;Tissues;Toxin;Type III Secretion System Pathway;Virulence;Virulence Factors;Vision;whole genome

PROJECT_TITLE: Extensively drug resistant Pseudomonas aeruginosa keratitis outbreak strain:  virulence mechanisms and mitigation

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: The proposed research will lay a foundation for developing innovative, individualized interventions to improve nonverbal communication (NVC) experiences for autistic adults, based on the values and first-hand experiences of our target population. Improvements in NVC are necessary for downstream improvements in a range of func- tional contexts, resulting in overall improved life outcomes associated with autism in adulthood. This project is relevant to NIDCD’s mission pertaining to intervention, and to the NIH’s Interagency Autism Coordinating Com- mittee’s dual missions related to intervention and lifespan issues. This project will produce a set of specific, stakeholder-driven recommendations for designing and prioritizing NVC intervention development, opening new horizons for how NVC is conceptualized and addressed in autism.

PI_NAMEs: DE MARCHENA, ASHLEY BROOKE (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Adult;adult with autism spectrum disorder;Age;Area;Autism Diagnosis;autism spectrum disorder;autistic;Behavioral;career;Child;Collaborations;Communication;Communities;community consultation;Consultations;Data;Data Collection;design;Development;disability;Education;Employment;Evidence based intervention;experience;Eye;Facial Expression;follow-up;Foundations;Future;Gestures;Goals;Grant;Guidelines;Hand;Healthcare;Heterogeneity;improved;Individual;Individual Differences;individuals with autism spectrum disorder;innovation;Intervention;Interview;Investments;Knowledge;Language;Life;life span;Machine Learning;Maps;member;Mental Health;Methods;Mission;Modeling;National Institute on Deafness and Other Communication Disorders;Nature;Nonverbal Communication;novel;Outcome;Participant;Patient Recruitments;Patient Self-Report;Pattern;preference;prospective;Quality of life;Recommendation;recruit;Research;Research Methodology;Research Personnel;Resources;response;Sampling;skills;Structure;success;Surveys;Target Populations;Testing;therapy development;Toddler;tool;trait;United States National Institutes of Health;verbal;wasting

PROJECT_TITLE: Establishing Intervention Priorities for Nonverbal Communication in Autistic Adults

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative (parent grant) The overall goal of this proposal is to dissect the molecular mechanisms of metabolic regulation of ATP-citrate lyase (ACLY) and to characterize ACLY inhibitors for cancer therapy. Together, these studies will elucidate how cellular metabolites, and posttranscriptional and posttranslational modification, tune ACLY activity and will lead to the rational development of ACLY drugs to treat cancer.

PI_NAMEs: BURSLEM, GEORGE ;MARMORSTEIN, RONEN  (contact);WELLEN, KATHRYN ELAINE

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Acetates;Acetyl Coenzyme A;Acetylation;Acids;Address;adduct;ATP Citrate (pro-S)-Lyase;Binding;Biochemical;biophysical analysis;cancer cell;Cancer cell line;cancer therapy;Cardiovascular Diseases;Career Mobility;Catabolism;Catalysis;Cellular biology;Cholesterol;Citrates;Citric Acid Cycle;Coenzyme A;Collaborations;Cryoelectron Microscopy;Development;Disease;Enzymes;Esters;Exons;experimental study;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;FDA approved;Funding;Gene Expression;Genetic;Glucose;Goals;Grant;Hepatic;Hepatocyte;Human;Individual;inhibitor;inhibitor therapy;isoprenoid;Knock-out;Knowledge;Lead;lipid metabolism;Lipids;Liver;Malignant Neoplasms;Manuscripts;Mass Fragmentography;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolic Diseases;Modification;Molecular;Molecular Biology;Mus;Oxaloacetates;Palmitates;parent grant;Pharmaceutical Preparations;Phenotype;Phosphorylation;Physicians;Positioning Attribute;Post-Translational Protein Processing;posttranscriptional;Primary carcinoma of the liver cells;Production;Protein Acetylation;Reaction;Regulation;Reporting;Research;Risk;Role;Scientist;skills;Source;Structure;Therapeutic Uses;Training;transcriptome sequencing;tumor metabolism;United States National Institutes of Health;western diet;Work

PROJECT_TITLE: Metabolic regulation and inhibition of ATP-citrate lyase

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN JUAN

ORG_NAME: COMPREHENSIVE CANCER CENTER/ UNIV/PR

ORG_STATE: PR

PHR: PROJECT NARRATIVE Cervical cancer incidence rates are increasing in Puerto Rico, while screening uptake remains suboptimal. The proposed diversity supplement will promote Jeslie Ramos Cartagena's career development in cancer health disparities and health services research. As part of the proposed work, she will evaluate the history of cervical cancer screening uptake (pap and/or HPV testing) and adherence among cervical cancer patients in Puerto Rico, as well as the survival and lifetime cost of care in association with cervical cancer screening.

PI_NAMEs: DESHMUKH, ASHISH A.;ORTIZ, ANA PATRICIA (contact)

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Age;arm;budget impact;cancer health disparity;Cancer Patient;care costs;career development;Caring;Cervical;cervical cancer prevention;Cervical Cancer Screening;Clinic;Clinical;cohort;Collection;Colposcopy;Communities;cost effective;cost effectiveness;Death Rate;Diagnosis;Diagnostic Reagent Kits;Disasters;Disease;Disparity;Distant;Early Diagnosis;Effectiveness;effectiveness evaluation;effectiveness/implementation study;Eligibility Determination;Evaluation;Event;follow-up;Goals;Government;Health Services Research;High Prevalence;Home;home test;Human Papillomavirus;Hybrids;Hysterectomy;implementation evaluation;implementation outcomes;improved;Incidence;Individual;interest;Intervention;Intervention Studies;Interview;Island;Knowledge;life time cost;Low income;Maintenance;Malignant neoplasm of cervix uteri;mathematical model;Medicaid;Medicare;Minority Women;model design;models and simulation;Morbid Obesity;mortality;multi-component intervention;multidisciplinary;Natural History;novel;Obesity;Pap smear;parent grant;patient navigation;patient navigator;Patients;Population;Population Study;premalignant;President's Cancer Panel;Provider;Puerto Rico;Randomized, Controlled Trials;Recording of previous events;Recovery;Sampling;screening;screening participation;Screening Result;secondary analysis;secondary outcome;self testing;Site;Squamous intraepithelial lesion;success;survivorship;Testing;Transportation;Treatment outcome;trend;United States;uptake;Visit;Woman;women's outcomes;women's treatment;Work;World Health Organization

PROJECT_TITLE: Survivorship and cost of care of cervical cancer patients in Puerto Rico in association with cervical cancer screening


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative of Parent U01 AG071450 The overall goal of this project is to collect and disseminate critical data on cognitive, physical, and sensory functioning and risk for Alzheimer’s Disease and Related Dementias (ADRD) in Wave VI of the National Longitudinal Study of Adolescent to Adult Health (Add Health), when participants will be in their mid-40s. These new data, when combined with Add Health’s existing collection of extraordinarily rich multi-level and longitudinal measures and its new Wave VI data, will facilitate the scientific community’s understanding of the interplay of social, economic, behavioral, and biological factors that influence cognitive, physical, and sensory functioning in midlife and lead to ADRD in later life. Moreover, because Add Health is a diverse nationally representative sample, adding these data to Wave VI will greatly increase understanding of cognitive, physical, and sensory functioning within key health disparity populations in the United States.

PI_NAMEs: AIELLO, ALLISON E;HUMMER, ROBERT A (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Android;Behavioral;Biological;Biological Factors;Biological Markers;Biological Testing;Cardiac health;cardiovascular health;Certification;Clinical Trials Data Monitoring Committees;Cognition;Cognitive;cognitive function;cohort;Collection;Communities;Complex;complex data;Consent;cost;Coupled;Data;Data Collection;data exchange;data integration;data management;data quality;dementia risk;Devices;Diabetes Mellitus;Disparity;Drug usage;Early identification;Economics;Ensure;Environmental Exposure;ethnic diversity;Ethnic Origin;Evaluation;Foundations;Funding;Future;Goals;Health;health disparity populations;Hearing;Hearing Aids;hearing impairment;Home;Human Resources;Impaired cognition;improved;Individual;Interview;Interviewer;late life;Length;Life Cycle Stages;Longitudinal Studies;Measurement;Measures;meetings;middle age;National Longitudinal Survey of Adolescent to Adult Health;older adult;Online Systems;Parents;Participant;Persons;Physical assessment;Physical Function;Population;portability;Prevalence;Process;prospective;Protocols documentation;quality assurance;racial diversity;Recommendation;Regimen;Reporting;Research;Resources;response;Risk Factors;Risk Marker;Role;sample collection;Sampling;Sensory;Signs and Symptoms;smoking exposure;social;socioeconomics;Surveys;Testing;Time;tool;Training;transmission process;trend;United States;United States National Institutes of Health

PROJECT_TITLE: Hearing Assessment Supplement for Wave VI of Add Health


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_DEPT: MISCELLANEOUS

PHR: Project Narrative Intimate partner violence (IPV) contributes to maternal morbidity and pregnancy-associated deaths, particularly among populations with health disparities, but remains understudied. The Remap-IPV training aims to address this evidence gap through hybrid instruction and mentorship of underrepresented early career researchers. Training a diverse cohort of new investigators around IPV ethics and measurement rigor will contribute to IMPROVE goals of health equity and reducing preventable causes of maternal morbidity and mortality.

PI_NAMEs: HATCHER, ABIGAIL MAE (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;Adopted;Adult;adverse birth outcomes;Area;Behavioral;Biological;burnout;Businesses;California;career;Career Choice;career networking;Clinical;cohort;community building;community engagement;Complex;constructivism;Criminology;Data;design;digital;direct application;disability;Discipline;Discipline of Nursing;Discipline of obstetrics;Education;Educational Curriculum;Educational workshop;Ensure;Environment;Equity;Ethics;Event;experience;Exploration, Preparation, Implementation, and Sustainment;Faculty;Feedback;Forensic Medicine;Foundations;Funding;Future;gender minority status;Generations;Goals;Health;health disparity;health economics;health equity;health goals;high risk;Homicide;Household;Hybrids;Hypertension;implementation outcomes;improved;indexing;Inequity;Infant Health;innovation;insight;Instruction;Intervention;Interview;intimate partner violence;Investments;Learning;lectures;Libraries;Licensing;Life;Link;Longevity;Manuscripts;Maps;marginalized population;Maternal Health;maternal morbidity;Maternal Mortality;Measurement;Measures;Medical Ethics;meetings;Mental disorders;Mentors;Mentorship;Methodology;Modeling;Mothers;next generation;North Carolina;novel strategies;obstetrical complication;online course;Outcome;Paper;Participant;Patients;Peer Review;Perinatal;Persons;Population;Population Study;Postpartum Period;Poverty;Pregnancy;Pregnancy Outcome;pregnancy related death;pregnant;Premature Birth;prevent;preventable death;Process;Productivity;programs;Protocols documentation;Provider;Psychiatry;psychologic;Psychology;Public Health;Race;Research;Research Personnel;Research Proposals;Research Support;resilience;Resources;satisfaction;Scientist;Severities;Sexual and Gender Minorities;sexual violence;Sexuality;skill acquisition;skills;Slide;social;social epidemiology;socioeconomics;Sociology;Surveys;symposium;System;Techniques;Technology;Testing;Time;tool;Traineeship;Training;training opportunity;translational impact;Trauma;Trust;United States;United States National Institutes of Health;Universities;Violence;Vision;Work;Writing;years of life lost to disability

PROJECT_TITLE: Restoring equity to measuring and preventing perinatal intimate partner violence (Remap-IPV)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-H (53)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Precision Medicine

PHR: PROJECT NARRATIVE This proposed research is relevant to human health because clinical pharmacogenetic testing may improve the personalization of drug therapy which should improve patient outcomes. Better understanding of the effectiveness and feasibility of clinical pharmacogenetic testing in the emergency department will inform when and how this innovative healthcare technology is implemented into clinical care, particularly in acute care settings. The combined proposed research are relevant to the parts of the NIH’s mission pertaining to protecting and improving health and developing scientific human resources that will ensure the Nation's capability to prevent and treat disease.

PI_NAMEs: DUARTE, JULIO DAVID (contact);SHEIKH, SOPHIA

PROGRAM_OFFICER_NAME: CHANG, CHRISTINE Q

PROJECT_TERMS: Accident and Emergency department;acute care;Address;Admission activity;Affect;Ambulatory Care;Caring;Clinical;clinical care;clinical implementation;comparison intervention;cost;cost comparison;cost effectiveness;Cost efficiency;cost estimate;Costs and Benefits;CYP2D6 gene;Data;Disadvantaged;Disease;Drug Prescriptions;economic impact;Economics;Effectiveness;Emergency Department patient;Emergency department visit;emergency settings;Emergency Situation;empowerment;Ensure;Environment;Event;experience;experimental study;follow-up;Future;gene interaction;Genes;Genetic Variation;Goals;Health;Health Care Costs;health care disparity;Health system;Health Technology;high risk;Hospitalization;hospitalization rates;Hospitals;Human;Human Resources;implementation efforts;implementation strategy;improved;incremental cost;innovation;Institution;Intervention;Measures;Medical;Methods;Mission;Multi-Institutional Clinical Trial;Outcome;Pain;Patient Care;patient population;Patient-Focused Outcomes;Patients;personalized care;Pharmaceutical Preparations;Pharmacists;pharmacogenetic testing;Pharmacogenetics;Pharmacotherapy;portability;Pragmatic clinical trial;precision drugs;precision medicine;preference;prescription opioid;prevent;Primary Care Physician;Randomized;recidivism;Recommendation;Research;Resources;response;Risk;side effect;Surveys;Testing;Time;treatment as usual;trial comparing;United States National Institutes of Health;uptake;user centered design;Visit

PROJECT_TITLE: Clinical Expansion of Precision Medicine in the Emergency Department

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (M4)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: NOTRE DAME

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NOTRE DAME

PHR: NARRATIVE Mechanical properties and forces the body are often modulated during disease initiation and progression. However, little is known about the response of immune cells to these mechanical cues, particularly at the tissue- length scale, and even in normal physiological settings. Establishing an omics-based understanding of functional immunological changes in response to mechanical perturbations will broaden our knowledge of “mechano- immunology” – a burgeoning subfield in basic biomedical sciences that in the near future will reveal new pathophysiological insights and targetable vulnerabilities for human disease.

PI_NAMEs: DATTA, MEENAL  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: adaptive immune response;adaptive immunity;Affect;Animal Model;Antigen Presentation;Antigens;Artificial Intelligence;Atomic Force Microscopy;Back;Behavior;Benchmarking;Bioinformatics;Biometry;Biophysics;Bioreactors;Categories;CD4 Positive T Lymphocytes;CD8B1 gene;cell behavior;Cell Communication;Cells;cellular engineering;Cicatrix;Circulation;Coculture Techniques;Cues;cytotoxic;Cytotoxic T-Lymphocytes;Data;data integration;Disease;Disease Progression;Dissociation;Engineering;exhaust;experimental study;Extravasation;Future;Generations;Genetically Engineered Mouse;Hour;human disease;Image;Immune;Immune response;Immune system;Immune Targeting;Immunocompetent;immunogenic;Immunologics;Immunology;improved;In Vitro;in vivo;Inflammatory Response;Innate Immune System;insight;Knockout Mice;Knowledge;Laboratories;Length;Liquid substance;live cell imaging;lymph nodes;Lymphoid;Lymphoid Cell;Macrophage;mechanical force;mechanical properties;mechanical signal;Mechanics;Mediating;Methods;Modeling;Molecular;monocyte;Motility;mouse model;multiphoton microscopy;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;National Institute of General Medical Sciences;Natural Immunity;Organ;pathogen;Pathologic;Phenotype;Physiological;programs;Property;Regulatory T-Lymphocyte;Research;Research Personnel;response;Risk Management;Role;Science;Series;shear stress;single-cell RNA sequencing;Site;Skin;Slice;Solid;Spleen;Stress;Stromal Cells;success;Swelling;System;Techniques;Testing;therapy resistant;Thymus Gland;Tissues;tool;trafficking;transcriptomics;Transgenic Organisms;Translational Research;viscoelasticity;wound

PROJECT_TITLE: Establishing an immune mechanome


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Emergency Care;Fentanyl Misuse and Addiction;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The purpose of this R01 supplemental proposal is to deepen our knowledge of the primary cause of drug overdose deaths in the U.S. today: novel psychoactive synthetic opioids, the majority of which are fentanyl analogues. Using a nationwide registry of patients who present to emergency departments, novel fentanyl analogue overdose will be studied in terms of its epidemiology, analytical confirmation, clinical risk factors, and treatment needs, by a uniquely qualified multidisciplinary team with an extensive track record of collaboration in the field. The overall specific aims of this proposal, are three-fold: (1) state-of-the-art toxicology analytics, as well as biomarkers of clinical severity; (2) treatment requirements such as naloxone, need for critical care and/or mechanical ventilation; and (3) regional and temporal trends nationwide.

PI_NAMEs: MANINI, ALEX FRANCIS (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: abuse liability;Accident and Emergency department;addiction;Address;Admission activity;Adverse effects;Affect;American;Biological Markers;Caring;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Chronology;Clinical;Clinical Data;clinical effect;Clinical Management;clinical risk;cohort;Collaborations;Commerce;cost;Critical Care;Data;design;Diagnosis;Disease Outbreaks;Drug abuse;drug of abuse;Emergency Care;Emergency Department evaluation;Emergency Department patient;Emergency department visit;Enrollment;Epidemic;Epidemiology;Evaluation;fentanyl analog;fentanyl overdose;Forensic Medicine;Heroin;heroin overdose;Hospitals;illicit opioid;improved;Incidence;Ingestion;insight;Knowledge;Length of Stay;Liquid Chromatography;Mechanical ventilation;Medical;Molecular;Morphine;multidisciplinary;Naloxone;naloxone dosing;National Institute of Drug Abuse;novel;Opioid;opioid epidemic;opioid overdose;opioid use;organ injury;Outcome;Overdose;overdose death;patient registry;Patient Self-Report;Patients;Pattern;Periodicals;Pharmaceutical Preparations;Poison;Population;prescription opioid;Prevalence;Principal Investigator;Property;prospective;Prospective, cohort study;Public Health;Qualifying;regional difference;Reporting;Research;Research Activity;Research Personnel;Resource Allocation;Resources;Risk Factors;Sampling;screening;sedative;Severities;sex;Standardization;stem;substance use;synthetic opioid;System;tandem mass spectrometry;Testing;Time;time of flight mass spectrometry;Time trend;Toxicology;Treatment Protocols;trend;trend analysis;Visit;web site

PROJECT_TITLE: CDC Supplement Year 3

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(58)-R]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: PONCE

ORG_NAME: PONCE SCHOOL OF MEDICINE

PHR: Project Narrative Identifying and targeting signaling pathways regulated by the mitotic kinases Nek2 and TTK, which are overexpressed in non-Hispanic Black (NHB) and Hispanic/Latina (H/L) with breast cancer will reduce breast cancer health disparities by preventing early metastatic progression in NHB, Caribbean-H/L, and other H/L breast cancer patients. The investigators aim to elucidate these pathways using cell lines, and PDX models of breast cancer established from NHB and H/L patients.

PI_NAMEs: CRESS, WILLIAM DOUGLAS;SAAVEDRA, HAROLD I (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Affect;African ancestry;African Women;aggressive breast cancer;Apoptosis;Biological Response Modifier Therapy;Black race;black women;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;cancer health disparity;cancer subtypes;Caribbean Hispanic;Caribbean region;Cell division;Cell Line;cell motility;Centrosome;Death Rate;Detection;epithelial to mesenchymal transition;Estrogens;Ethnic Origin;Genetic Transcription;Genome;Genomics;Goals;Hispanic;Invaded;Latina;Latina Population;Latino;Malignant Breast Neoplasm;Mammary Neoplasms;Messenger RNA;Mitotic;Neoplasm Metastasis;Not Hispanic or Latino;novel;novel therapeutic intervention;overexpression;Parents;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Phosphorylation;Phosphotransferases;Population;Prevalence;prevent;Progesterone;Prognosis;Proteins;Publishing;Race;receptor;Reporting;Research Personnel;Signal Pathway;Signal Transduction;Signal Transduction Pathway;transcription factor;triple-negative invasive breast carcinoma;White Women;Woman

PROJECT_TITLE: Targeting centrosome-mitotic kinases as a novel therapeutic approach against breast cancers in Hispanic/Latinas. Supplement1


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Radiation Oncology;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Cervical cancers are a leading cause of death among women worldwide, and in the U.S. affects more Black and Hispanic women than other groups. Treatment by implantation of radioactivity into the tumor with MR-guidance (MR- brachytherapy) has significantly improved survival. We accelerate MR-brachytherapy with better tumor detection and will integrate in Dr. Gardner’s overall goal to improve access to advanced radiation therapy.

PI_NAMEs: VISWANATHAN, AKILA  (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Acceleration;advanced disease;Affect;automated segmentation;Biological Markers;black women;Bladder;Blood Vessels;Brachytherapy;Cancer Etiology;Catheters;Cause of Death;Cervical;Clinical Research;Collaborations;Data Set;design;Detection;Diagnosis;Diffusion;Disease;Dose;Electromagnetics;Endometrial;Engineering;Evaluation;External Beam Radiation Therapy;Fibrosis;Goals;Guidelines;Gynecologic;Hispanic Women;Human Papillomavirus;Image;Image Analysis;image guided;imaging modality;implantation;Improve Access;improved;innovation;interstitial;ionization;Location;Machine Learning;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Medical;Medical Imaging;Methods;millimeter;new technology;Nodal;Normal tissue morphology;novel;novel strategies;Outcome;Parents;Patient Transfer;Patients;Pelvis;Perfusion;Procedures;Property;Prostate;Radiation;Radiation Oncologist;Radiation Oncology;Radiation therapy;Radioactivity;radiologist;Rectum;Recurrence;Recurrent tumor;Research Project Grants;Residual Neoplasm;Roentgen Rays;Scanning;Scientist;Serum;side effect;Site;Societies;soft tissue;standard of care;Survival Rate;Time;tissue mapping;Tissues;tool;Toxic effect;treatment planning;tumor;tumor eradication;Universities;Unresectable;Vagina;Validation;Woman;women's diagnosis;Women's mortality;Work;X-Ray Computed Tomography

PROJECT_TITLE: Multiparametric Magnetic Resonance Imaging as a Novel Approach to Brachytherapy for Cervical Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(57)-R]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Neurosciences

ORG_CITY: SAN DIEGO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Public Health Relevance This research will benefit individuals who are deaf and use sign language as their primary language and will support the medical and rehabilitative organizations that serve this population. The findings will advance knowledge of the neural underpinnings of sign language, providing crucial information to clinicians and neurologists who are treating deaf patients with brain injury or disease.

PI_NAMEs: EMMOREY, KAREN  (contact)

PROJECT_TERMS: Adopted;Agreement;American Sign Language;Area;Body part;Brain;Brain Diseases;Brain Injuries;Child;Cognition;cognitive neuroscience;Communication;cortex mapping;Coupled;deaf;density;design;Diagnosis;Electrophysiology (science);Event-Related Potentials;Exhibits;experience;experimental study;extrastriate;extrastriate visual cortex;Foundations;Functional Magnetic Resonance Imaging;Gestures;Goals;Hearing;Human;indexing;Individual;Inferior;Inferior frontal gyrus;Injury;insight;Investigation;Knowledge;Language;language comprehension;Language Development;Language Disorders;language impairment;language perception;language processing;Learning;Left;lexical;Linguistics;Location;Maintenance;Manuals;Maps;Medical;Methods;Modality;Modeling;Motor;Multimodal Imaging;National Institute on Deafness and Other Communication Disorders;Neighborhoods;neural;neural circuit;neural correlate;neural network;Neurobiology;Neurologist;Neurons;neurophysiology;Parents;Parietal Lobe;Patients;pedagogy;Perception;Personal Satisfaction;Persons;phonology;Population;practical application;Process;Property;Psychology;public health relevance;Recycling;Rehabilitation therapy;Research;response;Role;Semantics;Sensory;Shapes;Sign Language;sound;Speech;Speech Perception;Stimulus;Strategic Planning;Structure;Structure of superior temporal sulcus;Structure of supramarginal gyrus;support network;syntax;System;Testing;theories;United States;Visual;Visuospatial

PROJECT_TITLE: Language, Modality and the Brain

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: WILMINGTON

ORG_NAME: ASTRAZENECA PHARMACEUTICALS, LP

ORG_STATE: DE

PHR: PROJECT NARRATIVE In collaboration with Eolas Therapeutics and the NIH Blueprint Neurotherapeutics Network, AstraZeneca developed AZD4041, a novel treatment for opioid use disorder. In preclinical studies, AZD4041 decreased the motivational properties of opioids and has proven safe in a single ascending dose Phase 1 clinical study. In this proposal, we will conduct the additional clinical safety and early proof-of-concept clinical studies necessary to advance AZD4041 to the clinic as a potentially transformative treatment for opioid use disorder.

PI_NAMEs: GURRELL, IAN  (contact)

PROGRAM_OFFICER_NAME: ACRI, JANE

PROJECT_TERMS: Abstinence;addiction;Adverse event;aged;Animal Model;antagonist;Anxiety;Arousal;Attenuated;Behavior;Behavioral;Biological Availability;Blood;blood-brain barrier crossing;Brain;Buprenorphine;Canis familiaris;Carbon Dioxide;Cerebrospinal Fluid;Cessation of life;Chemistry;circadian;Clinic;Clinical;Clinical Research;clinically significant;cohort;Collaborations;craving;Dose;Double-Blind Method;Drug Addiction;Drug Kinetics;drug of abuse;drug seeking behavior;Drug usage;Economic Burden;efficacy evaluation;efficacy study;efficacy testing;Electrocardiogram;Enzymes;Evaluation;FDA approved;Food;healthy volunteer;Hematology;Human Volunteers;hypocretin;Hypothalamic structure;Impairment;Incidence;Laboratory Animals;Lateral;Measurement;Measures;Metabolic;Metabolism;Morphine;Motivation;Neuropeptides;Nicotine;novel;novel therapeutics;Opioid;opioid misuse;opioid use;opioid use disorder;opioid user;Oral;orexin 1 receptor;orexin A;orexin B;orexin B receptor;Overdose;overdose death;overdose risk;Oxygen;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Phase;Placebos;Plasma;Population;pre-clinical;preclinical study;primary endpoint;Primates;Process;programs;Property;Psychological reinforcement;Public Health;public health emergency;Randomized;Rattus;Recreation;Relapse;relapse prevention;respiratory;Risk;Rodent;Safety;safety assessment;safety study;Sampling;secondary endpoint;Sedation procedure;Serious Adverse Event;Signal Transduction;Sleep;Stress;tablet formulation;Testing;Therapeutic;Time;treatment group;United States National Institutes of Health;Urine;Ventilatory Depression;Withdrawal Symptom

PROJECT_TITLE: A novel and highly selective orexin 1 receptor antagonist for the treatment of patients with opioid use disorder.

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: MADISON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Parents, pediatricians, and clinicians are concerned when children begin to talk late, a condition that affects 15% to 20% of children. Yet, little is known about bilingual late-talkers, their ability to learn information in both languages, and persistence vs. resolution of their language delay. This project examines how Spanish-English bilingual toddlers with typical language, bilingual late-talker, and bilingual children with Developmental Language Disorder (DLD) learn novel words in English and Spanish and what conditions can best facilitate their learning, with a particular interest in identifying risk and protective factors in bilingual late-talkers’ language outcomes.

PI_NAMEs: KAUSHANSKAYA, MARGARITA  (contact)

PROJECT_TERMS: 2 year old;4 year old;Affect;Age;bilingualism;Child;Child Language;Cues;Development;Education;experimental study;Exposure to;Goals;Hour;improved;Individual;insight;interest;Intervention;Knowledge;Language;Language Delays;Language Development Disorders;language impairment;language outcome;Learning;Learning Disorders;Link;Literature;Maps;novel;Outcome;Parents;Participant;Pattern;pediatrician;peer;Predictive Factor;protective factors;Recording of previous events;Recovery;recruit;Resolution;Risk;Risk Factors;Role;Sampling;Series;Shapes;skills;Spanish;Spanish/English;spelling;statistical learning;stem;Structure;Suggestion;Testing;theories;Time;Toddler;United States;Vocabulary;word learning;Work

PROJECT_TITLE: Talking Late in Two Languages


NIH_SPENDING_CATS: Aging;Cancer;Chronic Obstructive Pulmonary Disease;Lung;Lung Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative To be most effective, treatments for lung diseases like chronic obstructive pulmonary disease must target cells in the airway and in the alveolar space where gas exchange occurs. This project seeks to understand the mechanisms by which alveolar cells respond to injury of the airways.

PI_NAMEs: HAIGIS, MARCIA  (contact);KIM, CARLA F.

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute;Affect;Age;aged;Aging;Alveolar;Alveolar Cell;alveolar epithelium;Alveolar Macrophages;career development;Cause of Death;Cell Communication;cell injury;Cell Proliferation;Cells;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Disease;Gases;Immune system;injured airway;Injury;insight;Learning;Lung;Lung Diseases;Macrophage;Malignant neoplasm of lung;Modeling;mortality;Mus;Naphthalene;old mice;parent grant;Proliferating;Research;Research Assistant;response;Risk Factors;stem cell function;stem cells;tissue regeneration;Tissues;Work

PROJECT_TITLE: Alveolar Responses to Airway Injury


ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PHS Relevance Statement Colorectal cancer (CRC) prevails as the third most common and deadliest cancer worldwide, affecting both men and women. Despite scientific breakthroughs, gaps in knowledge remain due to the multiple accumulation of molecular alterations occurring at onset and during disease progression. This study will investigate the role of the transcription factor STAT2 as a signaling mediator in the communication exchange between cancer cells and fibroblasts in the tumor microenvironment to accelerate disease progression.

PI_NAMEs: GAMERO, ANA M (contact)

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: Acceleration;Address;Affect;Animal Model;Award;Biopsy;cancer biomarkers;cancer cell;Cancer Model;cancer type;Cell Communication;Cell Line;Cell Separation;Cells;chemotherapy;Clinical;Colon;colon cancer patients;Colorectal Cancer;Communication;Conditioned Culture Media;CRISPR/Cas technology;Development;Diameter;Digestion;Disease Progression;EGF gene;experimental study;Fibroblasts;Freezing;Gene Expression Profile;Generations;Grant;Harvest;Image;Immunoassay;Immunocompetent;In Vitro;in vivo;Incubated;Injections;intercellular communication;Interleukin-2;Invaded;Investigation;Journals;Knockout Mice;Knowledge;Learning;Lentivirus Vector;Luciferases;luciferin;Malignant Neoplasms;MC38;Mediating;Mediator;men;Mentors;Metabolic;metastatic colorectal;migration;Modeling;Molecular;Mus;Neoplasm Metastasis;neoplastic cell;novel strategies;novel therapeutic intervention;Oncogenic;parent grant;Platelet-Derived Growth Factor;Play;Pre-Clinical Model;Process;Production;programs;Proliferating;Protocols documentation;Research;Role;Signal Transduction;STAT2 gene;Stat2 protein;Stromal Cells;subcutaneous;success;symposium;synthetic polymer Bioplex;System;targeted treatment;Techniques;Therapeutic Intervention;Time;timeline;Tissue Harvesting;transcription factor;transcriptome sequencing;Transforming Growth Factor beta;tumor;Tumor Cell Invasion;Tumor Cell Line;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenic;undergraduate student;vector;Western Blotting;Wild Type Mouse;Woman;Work

PROJECT_TITLE: Investigation of STAT2 Signaling in the tumor microenvironment


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Infectious Diseases;Lung;Pediatric;Pediatric Cancer;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: NARRATIVE. Juvenile-onset recurrent respiratory papillomatosis (JoRRP), caused by human papillomaviruses, are benign airway tumors whose repeated growth requires young patients to undergo frequent surgeries and can lead to malignancy and death. Using surgical specimens from dozens of JoRRP donors, we recently established rigorous laboratory models that, for the first time, allow for the studies required to develop much needed cures/drug treatments and also predictive biomarkers. With these break-though models, we propose to build on our substantial preliminary data to determine how viral and cellular factors coordinate to promote RRP disease, and to use the resulting data to explore diagnostic tools and therapeutic targets.

PI_NAMEs: SMITH, DAVID F;WELLS, SUSANNE I (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: 3-Dimensional;Address;Adjuvant Therapy;Adolescent;Aerodigestive Tract;Benign;Binding;Biological Assay;Biological Markers;Biopsy;Caring;Cell Culture Techniques;Cell Proliferation;Cells;Cessation of life;Chemicals;Child;Clinical;cohort;Data;delta protein;Development;Diagnosis;diagnostic tool;Disease;disease model;disease phenotype;ELF3 gene;Engineering;Epidermal Growth Factor Receptor;Epithelium;erbB-2 Receptor;ERBB2 gene;Exhibits;Gene Expression;Genetic Transcription;Goals;Growth;Heterodimerization;high risk;Histopathology;HPV negative;Human Papillomavirus;Human papillomavirus 11;Human papillomavirus 16;Human papillomavirus 18;Human papillomavirus 6;Individual;Integration Host Factors;keratinocyte;Knowledge;Laboratories;Length;Life Cycle Stages;Low risk HPV;Malignant - descriptor;Malignant Neoplasms;Methods;Modeling;Molecular;monolayer;Neoplasms;Oncogenes;Operative Surgical Procedures;Otolaryngologist;Papilloma;Pathology;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Prediction of Response to Therapy;predictive marker;Process;Production;Prognostic Marker;programs;Proliferating;Proteins;Publishing;Quality of life;Receptor Protein-Tyrosine Kinases;Recurrence;Recurrent respiratory papillomatosis;Repeat Surgery;Reporting;Respiratory System;Risk;Role;Signal Transduction;single-cell RNA sequencing;Site;Specimen;Squamous Epithelium;stem;Stratified Squamous Epithelium;Structure;Surface;Testing;Therapeutic;therapeutic biomarker;therapeutic target;three-dimensional modeling;Time;Tissues;Transcript;transcription factor;transcriptome;transcriptomics;tumor;Viral;Virus;Virus Replication;whole genome

PROJECT_TITLE: HPV and host factors in juvenile onset recurrent respiratory papillomatosis

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Hematology;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE GATA1 is a gene that is essential for red blood cell development, and mutations in GATA1 cause a spectrum of blood diseases in humans. In this proposal, we study the effect of one type of GATA1 mutations that lead to the loss of the N-terminal domain. We seek to define the function of this domain in red blood cell development and to understand how it controls metabolism and differentiation.

PI_NAMEs: CRISPINO, JOHN D (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Affinity;Alleles;Amino Acids;Anemia;Apoptosis;Basophilic Erythroblast;Binding;Biological Assay;Birth;Cell Line;Cell Maturation;Cells;Chromatin;chromatin remodeling;cofactor;Complex;Congenital Anemia;Coupled;Data;Dedications;Defect;Development;Diamond-Blackfan anemia;Disease;dyserythropoietic anemia;Embryo;Erythroblasts;Erythrocytes;Erythroid;Erythroid Cells;Erythropoiesis;Family;Fetal Liver;Flow Cytometry;GATA1 gene;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic Transcription;Globin;Glycolysis;Grant;Hematological Disease;Hematopoiesis;Hematopoietic;Hemolytic Anemia;Histone Acetylation;histone modification;Human;human induced pluripotent stem cells;Impairment;improved;in utero;in vivo;induced pluripotent stem cell;Inherited;innovation;Knockout Mice;Length;life span;Link;Macrocytic Anemia;Maps;Megakaryocytes;member;Metabolic;Metabolism;Methylation;Missense Mutation;Molecular;mouse model;Mus;mutant;Mutation;N-terminal;Names;novel;NuRD complex;Oxidative Phosphorylation;Pathway interactions;Patients;Phenotype;Population;Pregnancy;progenitor;Pronormoblasts;Protein Isoforms;protein protein interaction;Publishing;recruit;Reporting;Repression;Role;RUNX1 gene;single cell sequencing;single-cell RNA sequencing;Structure;SWI/SNF Family Complex;Thrombocytopenia;Transactivation;transcription factor;unpublished works;Zinc Fingers

PROJECT_TITLE: The role of the N-terminus of GATA1 in erythropoiesis

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Computer models of viruses assemble what we know and reveal what we do not about the process of infection. Enteroviruses and flaviviruses together cause nearly a billion-and-a-half infections globally each year. Reliable models for these viruses could provide a starting point for identifying therapeutic interventions when new outbreaks of the same viral family emerge.

PI_NAMEs: JANES, KEVIN A (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 2019-nCoV;antagonist;Anti-viral Response;Architecture;Binding;Biochemical;Biochemical Process;Bypass;Calibration;Cells;compare effectiveness;Computer Models;Coxsackie Viruses;Data;Dedications;Dengue;Dengue Virus;Disease;DNA-Directed RNA Polymerase;emerging pathogen;Enterovirus;experimental study;Family;Family Picornaviridae;Feedback;Fever;Flaviviridae;Flavivirus;Genetic Models;Genotype-Tissue Expression Project;Glean;Goals;Grain;head-to-head comparison;Health;hepatoma cell;HIV;Hour;Human;improved;in silico;Infection;infection rate;Influenza;innovation;Interferon Type I;Interferons;kinetic model;Life Cycle Stages;Literature;Liver;mathematical analysis;mathematical model;Measures;Membrane;Methods;Modeling;multi-scale modeling;new outbreak;Organ;Organelles;Organism;Outcome;Parameter Estimation;Pathogenicity;Pharmaceutical Preparations;Phase;Phylogenetic Analysis;Population Dynamics;Predisposition;Process;Production;Proteins;receptor;Resources;response;RNA;RNA Virus Infections;RNA Viruses;Route;Signal Transduction;simulation;single molecule;Skin;Source;Surface;System;Temperature;Testing;Therapeutic Intervention;trafficking;transcriptome;transmission process;Vaccination;Viral;Viral Genome;Virion;Virus;Virus Assembly;Virus Inhibitors;Virus Replication;Work

PROJECT_TITLE: In silico modeling of subcellular infection by diverse families of RNA virus

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]