ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative This proposal aims to launch a Coordinating Center to serve the goals of facilitating communication between the NIA Division of Behavioral and Social Research and the Centers on the Demography and Economics of Aging and Alzheimer's Disease and Alzheimer's Related Dementias, facilitating collaboration within and across these Centers and other NIA Centers, and disseminating research advances, activities, and resources to a broad audience of stakeholders. Through these efforts, the Coordinating Center significantly magnifies the impact of the Centers activities and findings.

PI_NAMEs: SONNEGA, AMANDA JANE (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Administrative Efficiency;Aging;aging demography;Alzheimer's Disease;Alzheimer's disease related dementia;Anniversary;Area;Behavioral;career;Collaborations;Collection;Communication;Data;Demography;Economics;Educational workshop;Effectiveness;Electronics;Fostering;Goals;Growth;improved;Infrastructure;innovation;interactive visualization;meetings;Methods;Michigan;Mission;Modeling;Newsletter;next generation;outreach;Play;Policies;Policy Maker;Population;population based;Population Genetics;Productivity;programs;Recording of previous events;Reporting;Research;Research Infrastructure;Research Personnel;Resources;social;Surveys;symposium;synergism;Universities;web site;Work

PROJECT_TITLE: Coordinating Center for the NIA Centers on the Demography and Economics of Aging and Alzheimer's Disease and Alzheimer's Related Dementias


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Prevention;Rare Diseases

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Multiple myeloma studies have revealed molecular subtypes with therapeutic and prognostic implications, but these fail to identify almost half of patients with poor outcomes, such as the proliferation myeloma subtype which is not defined by specific genetic alterations. This suggests an epigenetic regulation of proliferation gene expression, which will be investigated using computational analyses of somatic genetic alterations, tumor DNA methylation and gene expression in primary samples from the CoMMpass trial. Results will be integrated with patient outcomes to prioritize pathways for functional testing and follow-up mechanistic and translational studies.

PI_NAMEs: BARWICK, BENJAMIN GABRIEL (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: adaptive immunity;adverse outcome;Antibodies;B cell differentiation;Binding Sites;Biology;bisulfite sequencing;cancer risk;Cancerous;Cell division;Cell Line;Cell Proliferation;Cell secretion;Cessation of life;Chromosomes;Clinical Data;Clustered Regularly Interspaced Short Palindromic Repeats;Computer Analysis;Coupled;Data;Diagnosis;Disease;Disease Outcome;disorder risk;DNA;DNA Integration;DNA Methylation;DNA Modification Methylases;DNA Sequence Alteration;early experience;Epigenetic Process;epigenetic regulation;Event;Exhibits;follow-up;Foundations;Gene Expression;Genes;Genetic;genetic architecture;Genetic Markers;Genetic Transcription;genome sequencing;Genomics;Heritability;high risk;insight;Malignant Neoplasms;Maps;Mitotic;Modeling;Modification;Molecular;molecular marker;molecular subtypes;Multiple Myeloma;Multivariate Analysis;Mus;Mutation;Newly Diagnosed;Oncogenes;Outcome;Pathway interactions;Patient risk;patient stratification;Patient-Focused Outcomes;Patients;Phenotype;plasma cell differentiation;Plasma Cells;prognostic;Prognostic Factor;Prognostic Marker;prognostic of survival;programs;Proliferating;Refractory;Relapse;response;Risk;Role;Sampling;secondary analysis;Site;Specimen;Testing;Therapeutic;Training;transcription factor;transcriptome sequencing;translational study;tumor DNA;Tumor Suppressor Proteins;Untranslated RNA;Validation;whole genome;Work

PROJECT_TITLE: The genetic and epigenetic cartography of multiple myeloma

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: The proposed research is relevant to public health because neuromodulator systems are targets of most pharmaceutical treatments for psychiatric disorders, neurodegenerative disorders, and almost all drugs of abuse. Understanding the spatial, temporal, and context-dependent features of neuromodulator signaling is essential to explain neuromodulator function. Thus, the proposed research is relevant to NIH's mission to reduce illness and disability because it will, in the long term, help design better therapies that target specific features of neuromodulator signaling for neurological and psychiatric disorders.

PI_NAMEs: CHEN, YAO  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acetylcholine;Acute;Animal Behavior;awake;Behavior;Behavioral;Biochemical;Biological Assay;Biosensor;Brain;Calcium;cell behavior;Cell Physiology;Cells;cholinergic neuron;Complex;Coupled;Cyclic AMP-Dependent Protein Kinases;Data;Dendritic Spines;Dependence;design;disability;drug of abuse;Electrophysiology (science);Event;fluorescence lifetime imaging;Frequencies;G-Protein-Coupled Receptors;Glutamates;Goals;GTP-Binding Protein alpha Subunits, Gs;Head;Hippocampus;Image;imaging system;in vivo;innovation;insight;Learning;Light;Link;Location;Measures;Mediating;Memory;Mental disorders;Methodology;Mission;Modeling;Molecular;Mus;Muscarinic Acetylcholine Receptor;Nature;Nervous System Disorder;neural circuit;Neurodegenerative Disorders;Neuromodulator;Neuromodulator Receptors;novel;Optical reporter;optogenetics;Pattern;Peptides;personalized approach;Pharmacologic Substance;Phosphorylation;Phosphotransferases;Population;Positioning Attribute;protein activation;Protein Dynamics;Protein Kinase A Inhibitor;Psychiatric therapeutic procedure;Public Health;real-time images;receptor;Recording of previous events;Regulation;Reporter;Research;response;Role;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;Sleep;Slice;spatiotemporal;Specificity;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;System;targeted treatment;Technology;Testing;Time;tool;two-photon;United States National Institutes of Health;Vertebral column

PROJECT_TITLE: Spatial, temporal, and context-dependent features of GPCR-mediated protein kinase A activity

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Aging;Biotechnology;Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Neurodegenerative proteopathies share a common pattern: degeneration starts in one region, and eventually ramifies to other parts of the brain. Spinocerebellar ataxia type 1 (SCA1) is a paradigmatic neurodegenerative proteopathy, and the proposed studies will explore the factors and mechanisms that drive regional brain vulnerability to help us identify the best approaches to safely treat SCA1.

PI_NAMEs: ZOGHBI, HUDA Y (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Abnormal coordination;Affect;Age;Alleles;alpha synuclein;Alzheimer's Disease;Ataxia;ataxin-1;Binding;Brain;brain cell;Brain region;Brain Stem;Brush Cell;CAG repeat;Cell Nucleus;cell type;Cells;Cerebellar Nuclei;Cerebellum;Cessation of life;Cognitive;Compensation;Corpus striatum structure;Cytoplasmic Granules;Data;design;Disease;effective intervention;Etiology;excitatory neuron;Failure;Family;Functional disorder;functional restoration;Genes;Genetic Recombination;Genetic Transcription;Hippocampus;Human;Huntington Disease;Huntington gene;Immunoprecipitation;improved;Knock-in Mouse;Learning;LoxP-flanked allele;Mediating;Molecular;Motor;motor control;mouse model;Mus;mutant;Mutation;Nerve Degeneration;Neurons;Nuclear;paralogous gene;Parkinson Disease;Pathogenesis;Pathology;Pattern;Phenotype;polyglutamine;prevent;Production;Proteins;Proteomics;Purkinje Cells;Repression;Role;single nucleus RNA-sequencing;Spinocerebellar Ataxias;Symptoms;Therapeutic;Tissues;Toxic effect;trait;Transcription Repressor;transcriptomics;Transgenic Mice;Type 1 Spinocerebellar Ataxia;Work

PROJECT_TITLE: Molecular Studies of Spinocerebellar Ataxia Type 1

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: This project will identify common ways that M. tuberculosis bacteria avoids being killed by drugs that would normally work against them. It will also determine if this ability to avoid killing leads to relapse of disease after treatment. Identifying the shared mechanisms underlying these behaviors should make it possible to design new drugs that work better for treating TB and to develop new tests that can better guide therapy.

PI_NAMEs: ALLAND, DAVID  (contact);ELLNER, JERROLD J.;SALGAME, PADMINI

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Address;Aftercare;analytical tool;Antibiotic Resistance;Bacteria;Behavior;Cells;Clinical;clinical phenotype;Complex;design;Disease;Drug Exposure;Drug Interactions;Drug resistance;Drug Tolerance;Effectiveness;Exposure to;Genetic;Genetic Transcription;Genomics;Genotype;Goals;Heterogeneity;Household;Human;Immune;Immune response;Immune Tolerance;Immunity;Immunologics;in vivo;Individual;Infection;Inflammation;Laboratories;latent infection;Link;lung injury;member;Metabolic;mouse model;Mycobacterium tuberculosis;novel;novel therapeutics;Outcome;Participant;pathogen;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Population;Population Heterogeneity;prevent;programs;Recurrent disease;Relapse;response;Route;Sampling;Systems Biology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;trait;transmission process;Treatment outcome;treatment response;treatment trial;Tuberculosis;tuberculosis treatment;Work

PROJECT_TITLE: Bacterial and Host Heterogeneity in TB latency, persistence and progression


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Palliative Care;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative  Paid caregivers (e.g. personal care aides, home health aides, and other direct care workers) provide essential care that allows persons with dementia (PWD) to remain living at home, yet little is known about the lived experience of PWD receiving paid care. This project seeks to better understand factors that determine the roles that paid caregivers play in the home-based care of PWD. This will improve the care for PWD in the community by supporting the meaningful integration of paid caregivers in the person-centered dementia care team and guiding health policy to maximize the positive impact of paid caregivers on the lives of PWD.

PI_NAMEs: RECKREY, JENNIFER M (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: acute care;adverse outcome;Advisory Committees;Advocacy;Aging;aging population;base;Bathing;care coordination;career development;Caregivers;caregiving;Caring;Chronic;Clinical;clinically relevant;Communication;Communities;community organizations;community-level factor;Comprehensive Health Care;Data;Data Analyses;Dementia;dementia care;Dementia caregivers;design;Development Plans;Disease;Family;Family Caregiver;Family health status;family support;functional decline;global health;Health;Health Personnel;Health Policy;Health Professional;Health system;Healthcare Systems;Home;Home Health Aides;Impaired cognition;Impairment;improved;Income;innovation;insight;Interdisciplinary Study;Intervention;Interview;K-Series Research Career Programs;Knowledge;Lived experience;Long-Term Care;Medicaid;Medical;Medical Care Team;medical schools;member;Mentorship;Methods;Modeling;Monitor;Patient Care;Patients;payment;person centered;Personal Satisfaction;Persons;Play;Policies;programs;Provider;Qualitative Research;Research;Research Methodology;Research Personnel;Role;Self Care;Services;skills;social;social factors;Soil;stakeholder perspectives;Standardization;System;time use;Training;trend;waiver;Work

PROJECT_TITLE: The Role of Paid Caregivers in Home-Based Dementia Care

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: HIV/AIDS

PI_NAMEs: ALLAND, DAVID  (contact)

PROJECT_TERMS: Animals;Award;Biological Specimen Banks;Blood specimen;Brazil;Clinical;Clinical Data;Clinical Protocols;Clinical Research;Collaborations;Collection;Communication;Data;data centers;Data Coordinating Center;data management;data structure;Dedications;emerging pathogen;experience;Genomics;Heterogeneity;human subject;Infrastructure;Institution;international center;Lead;Logistics;meetings;Monitor;operation;Policies;Principal Investigator;Procedures;programs;Progress Reports;Protocols documentation;Public Health;Research;research and development;Research Personnel;Resolution;Resources;Site;Specimen;Structure;System;Systems Biology;Training;Uganda;United States National Institutes of Health;Validation;web platform;Work

PROJECT_TITLE: Administrative Core


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Nutrition;Pneumonia;Pneumonia and Influenza

ORG_CITY: Nashville

ORG_DEPT: PATHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Nutrient metals such as zinc (Zn) are essential for life but can only be obtained through dietary intake, indicating the need for careful Zn maintenance. This proposal will focus on identifying mechanisms used by Acinetobacter baumannii to overcome Zn deficiency that is encountered by pathogenic bacteria during infection. Successful completion of this project will identify the function of clients of the A. baumannii metallochaperone, ZigA, in combating Zn deficiency and will ascribe a role for ZigA clients during the pathogenesis of pneumonia.

PI_NAMEs: MILLER, JEANETTE MARIE (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acinetobacter baumannii;Affect;Anabolism;Bacteremia;Binding;Biochemical;Biological;Biological Assay;cell envelope;Cell Wall;Cells;Characteristics;chelation;Client;cofactor;combat;Data;Defect;Development;Diet;Dietary intake;Dietary Zinc;drug development;Ensure;Environment;Enzymes;Equilibrium;experience;experimental study;fitness;gene product;Generations;Genes;Genetic;genome-wide;Growth;Guanosine Triphosphate Phosphohydrolases;Homeostasis;human pathogen;Immune;Immune system;In Vitro;in vitro Assay;in vivo;Infection;Innate Immune System;insight;Iron;Laboratories;Leukocyte L1 Antigen Complex;Libraries;Life;Lytic;Maintenance;Malnutrition;Manganese;Mediating;metal chelator;metalloenzyme;Metalloproteins;Metals;Methods;microbial;mouse model;Multi-Drug Resistance;Mus;Mutagenesis;mutant;Names;new therapeutic target;Nosocomial pneumonia;novel therapeutics;Nutrient;Nutritional Immunity;opportunistic pathogen;Organism;Pathogenesis;pathogenic bacteria;Pathway interactions;Peptidoglycan;Permeability;Phagocytes;Phenotype;Play;Pneumonia;pneumonia model;prevent;Process;Property;protein protein interaction;Proteins;Reactive Oxygen Species;Recycling;response;Role;Sequence Homology;Series;Starvation;Stress;synergism;Testing;Therapeutic;transposon sequencing;Vertebrates;Virulence;Western Blotting;Work;Zinc;Zinc Chloride;Zinc deficiency

PROJECT_TITLE: Strategies for Acinetobacter baumannii to Maintain Zinc Homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-K(20)]


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS

PI_NAMEs: WHALEN, CHRISTOPHER C. (contact)

PROJECT_TERMS: biobank;Biological;Brazil;Clinical;clinical epidemiology;Clinical Protocols;Clinical Research;Collaborations;Collection;Data;Data Analyses;Data Collection;data integrity;design;Development;Ensure;epidemiologic data;Epidemiology;Equipment and supply inventories;Ethics;Heterogeneity;Human;human subject;Immune;International;Investigation;Laboratories;Lead;Manuscripts;Monitor;Mycobacterium tuberculosis;Natural History;operation;Participant;Patients;Principal Investigator;programs;Prospective cohort;protocol development;Protocols documentation;quality assurance;Quality Control;recruit;Regulation;Reporting;Research Design;Research Personnel;research study;Retrospective cohort;Retrospective cohort study;Safety;sample collection;Sampling;Site;Specimen;Statistical Data Interpretation;Study Subject;Systems Biology;Uganda;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Clinical Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Prevention

ORG_CITY: TUCSON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE There continues to be a need to engage students in cancer prevention and control research early in their academic training to inspire cancer prevention and control careers and renew the pool of scientists and clinicians in the field. The overall goal of this program entitled, “Student Transformative Experiences to Progress Undergraduate and Graduate Professionals” (STEP-UP) for cancer prevention is to provide undergraduate and Masters' degree seeking students with an intensive, hands-on summer research experience in cancer prevention and control. This research training experience includes the conduct of a mentored research project, didactic instruction, and career development guided by highly experienced multidisciplinary leadership and mentoring teams with peer reviewed research funding, to assure a quality program that will build and sustain the cancer prevention and control workforce of the future.

PI_NAMEs: BEA, JENNIFER WRIGHT (contact);GARCIA, DAVID O.

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Academic Training;Address;Age;Aging;American Indian community;anti-cancer research;Arizona;Awareness;Behavior;Cancer Center;Cancer Control;Cancer Control Research;cancer health disparity;cancer prevention;cancer risk;cancer survival;care providers;career;career development;Career Exploration;career networking;Caring;Catchment Area;Communities;community engagement;community partners;Comprehensive Cancer Center;Continuing Education;design;Discipline;dissemination research;early-career faculty;Education;Educational Activities;empowerment;Enrollment;Ensure;Environmental Hazards;Ethnic Origin;Evaluation;experience;Faculty;faculty community;faculty mentor;Feedback;Fostering;Funding;Future;Goals;graduate student;Grant;Habits;hands on research;health disparity;Health Promotion Sciences;Health Sciences;Healthcare;Hispanic;human old age (65+);Immersion;improved;improved outcome;innovation;Institution;Instruction;Interdisciplinary Study;interest;International;intrinsic motivation;Investments;Knowledge;Laboratory Research;Leadership;Learning;Life Style;Location;Malignant Neoplasms;member;Mentors;Mentorship;Methodology;Methods;multidisciplinary;Native Americans;NCI Center for Cancer Research;next generation;Obesity;Pathway interactions;pedagogy;peer;peer coaching;Perception;Populations at Risk;post-doctoral training;Prevention Research;Program Development;programs;Race;recruit;Research;Research Peer Review;Research Personnel;Research Project Grants;Research Training;Resources;Retirement;Risk;Risk Factors;Science;Scientist;Self Efficacy;senescence;senior faculty;Silver;skills;student participation;student retention;Students;summer research;Time;Training;Training and Education;Training Programs;Training Support;Tsunami;undergraduate student;Universities

PROJECT_TITLE: Student Transformative Experiences to Progress Undergraduate/Graduate Professionals (STEP-UP) for cancer prevention

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Data Science;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Rare Diseases;Tuberculosis

PI_NAMEs: JOHNSON, WILLIAM EVAN (contact)

PROJECT_TERMS: Automobile Driving;base;Biochemical Pathway;Bioinformatics;Biological;biological heterogeneity;Biological Process;biomarker signature;biomedical data science;causal variant;Cell Physiology;Cells;Clinical;Clinical Data;Clinical Investigator;clinical phenotype;Clinical Research;cohort;Collaborations;Computational Biology;Computational Technique;Computer Models;computerized data processing;Data;Data Analyses;data integration;Data Set;design;Disease;disease phenotype;Disease Progression;Drug Tolerance;Ensure;Etiology;experimental study;explainable machine learning;Gene Expression Regulation;Generations;Genes;Genetic Transcription;Heterogeneity;Human;Immunologist;Individual;insight;interest;Investigation;knowledgebase;Laboratory Study;lens;Link;machine learning method;Metabolic;Metabolism;metabolomics;microbial;Modeling;Modernization;Molecular;multimodality;Mus;Mycobacterium tuberculosis;network models;new technology;Outcome;pandemic response;pathogen;Pathway interactions;Phenotype;Physiology;Process;programs;Property;protein profiling;Recommendation;Research;Research Design;Research Personnel;Research Project Grants;Resolution;Role;Sampling;Serum Proteins;Service delivery model;Services;simulation;single-cell RNA sequencing;Standardization;statistical and machine learning;synergism;System;Systems Biology;transcriptome sequencing;transmission process;Tuberculosis;Validation;Work

PROJECT_TITLE: Systems Biology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: GENETICS

PHR: Project Narrative: Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease and most common form of dementia throughout the world. One of the causative disease driving proteins of AD is the accumulation of tau tangles in the brain. The goal of this project is to determine how cytoskeletal remodeling genes influences the brain’s native protein clearance pathways to lower tau accumulation as a potential therapeutic target to treat disease.

PI_NAMEs: STEPHENS, MORGAN CATHERINE (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: 70-kDa Ribosomal Protein S6 Kinases;actin depolymerizing factor;Actins;Adult;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;American;attenuation;Automobile Driving;Autophagocytosis;Behavior;Behavioral;Biochemical;Biological Assay;Biological Models;Brain;brain tissue;Cause of Death;Cell model;Cells;Clinical;cofilin;Color;combat;Communication;Complex;Cytoskeleton;Data;Dementia;Dendritic Spines;density;Deposition;Development;disability;Disease;Disease Progression;Distal;Drosophila genus;Environment;Etiology;extracellular;Genes;Genetic;Genetic Screening;Goals;Harvest;Histologic;histological studies;Histology;Human;Human Cell Line;Huntington Disease;hyperphosphorylated tau;Impairment;improved;In Vitro;in vitro Assay;in vivo;insight;knock-down;LIM Domain;Lysosomes;Malignant Neoplasms;Measures;Mediating;Microfilaments;Microscopy;misfolded protein;Modeling;Modification;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;Nerve Degeneration;nerve stem cell;Neurodegenerative Disorders;neurodegenerative phenotype;Neurofibrillary Tangles;neuroinflammation;Neuronal Dysfunction;Neurons;neuropathology;neurotoxic;new therapeutic target;novel;overexpression;Parkinson Disease;Pathogenesis;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Phase;Phosphotransferases;Prevalence;prevent;Process;protein aggregation;protein degradation;Proteins;proteostasis;Regulation;Research;Resolution;response;Rod;Role;Senile Plaques;Societies;Synapses;System;tau aggregation;tau Proteins;Tauopathies;Techniques;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;trafficking;Transmission Electron Microscopy;Ubiquitin;United States;Vesicle;vesicle transport;wasting;Western Blotting

PROJECT_TITLE: INVESTIGATING THE ROLE OF THE CYTOSKELETON IN NEURODEGENERATION


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Telehealth

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Preterm infants are at high risk of brain injury and there is increasing awareness of a link between neurological injury associated with prematurity and later-to-emerge psychopathology associated with self-regulatory deficits including Attention-Deficit/Hyperactivity Disorder and clinical levels of internalizing and externalizing behaviors. Based on our research and findings of other independent investigations, we have isolated parental responsiveness as a modifiable environmental factor that may normalize trajectories of neurological development with strong implications for improving short- and long-term mental health outcomes for children born preterm. Utilizing a scalable parenting intervention, conducted over the internet, the proposed research will address a paucity of data in this area by providing a benchmark for identifying if parental responsiveness is a modifiable psychosocial factor that improves neurodevelopmental outcomes and brain connectivity in children born preterm, thus directly advancing the NICHD’s mission to ensure the health, productivity, independence, and well-being of all people through optimal rehabilitation.

PI_NAMEs: BICK, JOHANNA RENEE;DEMASTER, DANA MCKENNA (contact);LANDRY, SUSAN

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Accounting;active control;Age;Anxiety;Area;Attention deficit hyperactivity disorder;Automobile Driving;awake;Awareness;Behavior;behavior change;Behavioral;behavioral construct;behavioral outcome;Benchmarking;Birth;Brain;Brain Injuries;brain morphology;Brain region;caregiving;Caring;Child;Child Rearing;Childhood;Clinical;clinical risk;Clinical Trials;Cognitive;comparison control;Data;Development;directed attention;early childhood;Electroencephalography;Ensure;Environmental Risk Factor;externalizing behavior;extreme prematurity;gray matter;Health;High Prevalence;high risk;Hippocampus;Home;Hyperactivity;improved;Impulsivity;inattention;Infant;Informal Social Control;innovation;Instruction;interest;Internet;Intervention;intervention effect;Investigation;learning strategy;Limbic System;Link;Magnetic Resonance Imaging;Maps;Measures;Mediating;Medical;Mental Depression;Mental disorders;Mental Health;Methodology;Mission;multimodality;National Institute of Child Health and Human Development;Nervous System Disorder;Nervous System Trauma;neural;neural circuit;Neuroanatomy;neuroimaging;Neurologic;Neurological outcome;Neuronal Plasticity;Neurophysiology - biologic function;novel;Online Systems;Outcome;parenting intervention;Parents;Participant;Pattern;Personal Satisfaction;Persons;Play;Population;post intervention;Prefrontal Cortex;Pregnancy;premature;Premature Infant;Problem behavior;Productivity;psychologic;Psychopathology;Psychosocial Factor;Randomized;Randomized, Controlled Trials;Rehabilitation therapy;Research;scaffold;Sleep;Structure;success;sustained attention;symptomatology;Technology;telecoaching;Testing;Thick;Toddler;treatment program;verbal;Videoconferencing;web-based intervention;white matter;Work

PROJECT_TITLE: A Randomized Control Trial of a Responsive Parenting Intervention to Support Healthy Brain Development and Self-regulation in Toddlers Born Preterm

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

PI_NAMEs: DIETZE, REYNALDO  (contact)

PROJECT_TERMS: active method;Address;Aerosols;Bacteria;Brazil;Categories;Classification;Clinical;comorbidity;design;Diabetes Mellitus;Diagnosis;Disease;Environment;Environmental Risk Factor;Evaluation;Exposure to;fluorodeoxyglucose;Funding;Gene Expression Profile;Heterogeneity;HIV Infections;Household;Human;Immune response;Immunologics;immunopathology;Impairment;indexing;Infection;infection risk;Inflammation;Inflammatory;Integration Host Factors;Lung Diseases;lung injury;Malnutrition;metabolomics;microbial;Modeling;Multi-Drug Resistance;Mus;Mycobacterium tuberculosis;Nature;Organism;Pathogenesis;Pathogenicity;Patients;Pattern;Peripheral Blood Mononuclear Cell;personalized approach;Persons;PET/CT scan;Phenotype;Population;predicting response;predictive signature;Preventive therapy;Process;progression risk;Prospective cohort;Proxy;pulmonary function;Recurrence;respiratory;Retrospective cohort;Retrospective cohort study;Risk;Side;South Africa;Sputum;Symptoms;synergism;Testing;Thoracic Radiography;Time;transcriptomics;transmission process;Tuberculin Test;Tuberculosis;Uganda

PROJECT_TITLE: Bacterial and host determinants of progression, manifestations and consequences of TB


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The membrane-interacting domains of class I viral fusion proteins, such as HIV-1 Env, appear to play much greater roles in its stability, function and antigenicity than what has been appreciated previously. This proposal aims to determine atomic structures of these domains in a physiologically relevant environment, to assess their functional roles in viral infection and to facilitate development of intervention strategies.

PI_NAMEs: CHEN, BING  (contact);HARRISON, STEPHEN COPLAN

PROGRAM_OFFICER_NAME: CHAKRABARTI, BIMAL KUMAR

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Adopted;Alanine;Animal Model;Architecture;Biogenesis;Biological Assay;Cell fusion;Cells;Chimeric Proteins;Computer Models;Coupled;COVID-19 pandemic;Cryoelectron Microscopy;Cytoplasmic Tail;Data Analyses;Detergents;Disease;Elements;env Gene Products;Environment;fascinate;fighting;Funding;Goals;HIV;HIV-1;Infection;insight;Intervention;Length;Lipid Bilayers;Lipids;Macaca mulatta;Membrane;Membrane Fusion;Membrane Proteins;Molecular Conformation;Mutagenesis;nanodisc technology;nanodisk;novel;Peptides;Physiological;Play;Preparation;Process;Property;protein folding;protein reconstitution;protein structure;Proteins;Protocols documentation;Research;Resolution;Role;Sampling;SARS-CoV-2 spike protein;Scanning;SIV;Structure;Tail;Technology;Testing;therapeutic development;therapeutic target;therapy development;Transmembrane Domain;vaccine development;vaccine trial;Vaccines;Viral;Viral Fusion Proteins;Virus;Virus Assembly;Virus Diseases;Visualization

PROJECT_TITLE: Structure-function studies of the membrane-interacting domains of HIV-1 Env spike

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative Anaplasma, tick-borne pathogenic bacteria that cause disease in a wide range of animals including humans and livestock, lead an obligate intracellular lifestyle, cycling between the cells of their tick and vertebrate hosts. Switching between these hosts involves extensive reprogramming of Anaplasma gene expression to facilitate adaptation to these distinct intracellular niches. Here we investigate how a regulatory protein recognizes DNA targets to orchestrate the transcriptional remodeling underpinning adaptation of Anaplasma to the tick host, and how disruption of this protein compromises bacterial survival inside tick cells.

PI_NAMEs: PARK, JASON MICHAEL (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Anaplasma;Anaplasma phagocytophilum;Animals;Architecture;Arthropod Vectors;Arthropods;Attenuated;Bacteria;Binding;Bioinformatics;Biology;Body Temperature;Cell Culture Techniques;Cell Survival;Cells;Cues;Dependence;Development;Disease;disease transmission;Disparate;Disparity;DNA;DNA Binding;DNA Binding Domain;DNA Sequence;DNA-Binding Proteins;Environment;Evolution;Face;Family;Gene Expression;gene network;Genes;genetic regulatory protein;Genetic Transcription;Genome;Genomics;Growth;Helix-Turn-Helix Motifs;Homologous Gene;Human;Human Cell Line;Immunologics;Infection;innovation;Intervention;Lead;Life Cycle Stages;Life Style;Livestock;Mammalian Cell;Mammals;Measures;Modeling;Mus;mutant;Mutate;Mutation;Nutrient availability;Operon;pathogen;pathogenic bacteria;Pathogenicity;Pattern;physical property;Physiological;pressure;Proteins;Regulon;Repression;Research;response;Response Elements;Rickettsia;Role;Side;Stimulus;Structural Models;Testing;tick-borne;Tick-Borne Diseases;Ticks;transcription factor;Transcriptional Regulation;transcriptome;transmission process;United States;vector;vector transmission;vector-borne;vector-borne pathogen;Vector-transmitted infectious disease;Work;Xenobiotics

PROJECT_TITLE: Exploring Tr1-regulated transcription networks underpinning adaptation of pathogenic Anaplasma to the tick host

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Infant Mortality;Infectious Diseases;Machine Learning and Artificial Intelligence;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Sepsis;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Worldwide, more than 600,000 newborns die from infections each year. India has one of the highest burdens of newborn deaths due to bacterial infections, which are commonly resistant to antibiotics. In this study, I will identify risk factors for newborn bloodstream infections, develop a method for predicting antibiotic-resistant infections, and create an infection prevention survey to reduce risk of infections in hospitalized babies in Indian Neonatal Intensive Care Units.

PI_NAMEs: JOHNSON, JULIA  (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Address;Admission activity;Algorithms;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Antimicrobial Resistance;Assessment tool;Bacterial Infections;bacterial resistance;biobank;Biometry;Birth;Blood;carbapenem resistance;Carbapenems;career;Caring;Cephalosporins;Characteristics;classification trees;Clinical;clinical investigation;Clinical Investigator;cohort;Cohort Studies;Colistin;Communicable Diseases;Communities;critically ill newborn;Data;Data Analyses;Death Rate;Decision Making;Decision Trees;Development;Devices;Disease Outbreaks;Engineering;Enrollment;Epidemiologic Methods;Epidemiology;Future;Generations;Goals;Gram-Negative Bacteria;Hand;Health care facility;health care model;Healthcare;healthcare burden;healthcare-associated infections;high risk;hospital care;Hospitalization;Human;Hygiene;Immune system;improved;improved outcome;Incidence;India;Infection;Infection Control;Infection prevention;infection risk;Intensive Care;Intervention;Investigation;Klebsiella pneumoniae;Length of Stay;Life;low and middle-income countries;machine learning model;Measures;Mechanical ventilation;Mentors;Mentorship;Methodology;Methods;Modeling;modifiable risk;Morbidity - disease rate;mortality;Neonatal;neonatal care;neonatal health;neonatal infection;Neonatal Intensive Care Units;Neonatal Mortality;neonatal sepsis;neonate;Newborn Infant;Nosocomial Infections;novel;Organism;pathogen;Pathway interactions;patient oriented research;patient safety;Patients;Pneumonia;Positioning Attribute;predictive modeling;premature;Prevalence;prevent;Principal Investigator;Procedures;prospective;Prospective cohort;Prospective, cohort study;Recommendation;Rectum;regression trees;Research;Research Personnel;Resistance;Resistance to infection;Resource-limited setting;Risk Factors;Risk Reduction;Sepsis;Site;skill acquisition;skills;Surveys;tertiary care;Testing;Time;tool;Training;treatment strategy;Universities;Work

PROJECT_TITLE: Preventing antimicrobial resistance and infections in hospitalized neonates in low resource settings

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Nutrition

ORG_CITY: MEMPHIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Project Narrative Nutrient signaling and metabolism significantly affects health and disease by regulating the epigenome through mechanisms that remain to be defined. This project will delineate how the conserved mechanistic target of rapamycin complex 1 (mTORC1) nutrient regulated pathway controls the epigenome to promote cell survival and metabolic transcription.

PI_NAMEs: LARIBEE, RONALD  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acetylation;Address;Affect;analog;Architecture;Binding;Biochemical;Cell Death;cell growth;Cell Nucleus;Cell Proliferation;Cell Survival;Cells;chemical genetics;ChIP-seq;Chromatin;Chromatin Structure;Collaborations;Complex;Coupled;Critical Pathways;Cytoplasm;Deacetylase;Disease;Engineering;Environment;Epigenetic Process;epigenetic regulation;epigenome;FRAP1 gene;Future;Gene Expression;Genes;Genetic;genetic analysis;Genetic Screening;Genetic Transcription;Genomic approach;Goals;Health;Histone Acetylation;Histone Deacetylase;Histone H3;Histone H4;histone modification;Histones;HMGB Family Gene;HMGB1 gene;Homeostasis;Homologous Gene;Human;Immune signaling;In Vitro;Individual;Inflammation;inhibitor;Knowledge;Libraries;Link;Lysine;Malignant Neoplasms;Metabolic;Metabolic Control;Metabolism;Mitochondria;Modeling;mutant;novel;Nutrient;Nutrient availability;nutrient metabolism;Obesity;Outcome;Pathologic;Pathway interactions;Peptides;Phenotype;Post-Translational Protein Processing;prevent;Process;Proliferating;Proteins;Proteomics;Reader;Regulation;Repression;Role;Signal Pathway;Signal Transduction;Sirolimus;Sirtuins;Site;Stress;success;Testing;Transcriptional Regulation;transmission process;tumorigenesis;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Mechanisms of Target of Rapamycin Complex 1 Dependent Epigenetic Regulation

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

PI_NAMEs: SALGAME, PADMINI  (contact)

PROJECT_TERMS: adaptive immunity;Alveolar Macrophages;Antibody Response;Automobile Driving;Bacillus;biomarker signature;Blood;Brazil;C3HeB/FeJ Mouse;caseating granulomas;Categories;cell envelope;Cells;Characteristics;Chronic Phase;Clinical;clinical epidemiology;cohort;Complex;Cytometry;Data;design;Development;Diffusion;Dimensions;Disease;Disease Outcome;Disease Progression;Disparate;Drug Tolerance;effective intervention;Epidemiology;epidemiology study;Evolution;Exhibits;Exposure to;follow-up;Frequencies;Funding;Gene Expression Profile;Heterogeneity;Household;Human;IL17 gene;Immune;Immune response;Immunologics;Immunology;immunopathology;improved;in vivo;indexing;Individual;Infection;Inflammatory;Innate Immune Response;Intrinsic factor;Kinetics;latent infection;Lesion;Link;Lipids;liquid chromatography mass spectrometry;Lung;Machine Learning;Memory;Mus;Mycobacterium tuberculosis;nano-string;Necrotic Lesion;novel;pathogen;Pathogenesis;Pathologic;Pattern;Performance;permissiveness;Phase;Play;Population;Process;progression risk;Prospective, cohort study;Pulmonary Pathology;Regulation;relapse risk;response;Risk;risk prediction;Role;Sampling;segregation;Severity of illness;Shapes;Side;Subgroup;System;Systems Biology;T cell response;T memory cell;T-Lymphocyte;Technology;Testing;Therapeutic Intervention;Thoracic Radiography;transcriptome sequencing;Translating;transmission process;Tuberculin Test;Tuberculosis;Tuberculosis diagnosis;Uganda;Validation;Work

PROJECT_TITLE: Immune Determinants of the Course of Mycobacterium tuberculosis infection and                                                 Disease


ADMINISTERING_IC: DK

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury;Urologic Diseases

ORG_CITY: MILPITAS

ORG_NAME: STELLARTECH RESEARCH CORPORATION

ORG_STATE: CA

PHR: Narrative Overactive bladder (OAB) affects one in nine adults in the United States and is a source of great suffering for patients and huge costs to the healthcare system estimated at $70 billion per year. Current treatments are either based on low adherence drugs, recurring botulinum toxin injections, or neurostimulators, that either require exhaustive sessions, or costly invasive implantation. This proposal seeks to demonstrate preclinical safety and efficacy and to complete development of a game-changing therapeutic intervention based on recent understandings of bladder pathophysiology. The new minimally invasive, radiofrequency mucosal partitioning Uzap therapy is expected to provide an effective, single session, non-drug, non-implant solution for OAB and result in significant relief to patients as well as substantial cost savings.

PI_NAMEs: STERN, ROGER  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Ablation;Acute;Adult;Affect;Agonist;animal safety;Animals;Arousal;Attenuated;awake;base;Behavior;Bladder;Bladder mucosa;botulinum neurotoxin injection;Catheters;Cells;clinic ready;Clinical;Clinical Trials;Collaborations;commercialization;Connexins;cost;Cost Savings;design;Development;Devices;Dimensions;Documentation;Dose;Economic Burden;efficacy study;Electrodes;Engineering;experience;fabrication;Family suidae;Fibrosis;Financial cost;first-in-human;Functional disorder;Future;Gap Junctions;Grant;Granulation Tissue;Health;Healthcare Systems;Histologic;Histology;human study;Implant;implantation;improved;in vivo;Incontinence;Infiltration;Inflammatory;innovation;International;interstitial cell;Intervention;Legal patent;Lesion;Measurement;Mechanics;Medical Device;medication compliance;meetings;Miniature Swine;minimally invasive;Modality;Modeling;Mucous Membrane;neoplastic;non-drug;operation;Operative Surgical Procedures;Overactive Bladder;Patients;Pattern;performance tests;Persons;Pharmacologic Substance;Pharmacotherapy;Phase;Population;porcine model;preclinical efficacy;preclinical safety;Preparation;preservation;Procedures;psychosocial;radio frequency;Radiofrequency Interstitial Ablation;Recording of previous events;Recurrence;reduce symptoms;Refractory;Research;Research Personnel;Residual state;response;Risk Management;Safety;safety study;safety testing;side effect;Sleep;Source;Specimen;Spinal cord injury;Symptoms;System;Testing;Therapeutic;Therapeutic Intervention;Thermal Ablation Therapy;Tissue Model;Tissues;Ultrasonics;United States;Urethra;Urodynamics;Urologist;usability;verification and validation;women patients;Work

PROJECT_TITLE: Clinical readiness of Uzap - the minimally invasive Overactive Bladder treatment


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Precision Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Pasadena

ORG_NAME: DOHENY EYE INSTITUTE

PHR: Project Narrative  The impending health epidemic of age-related macular degeneration (AMD) creates an urgent need to develop treatments that prevent AMD or stop its progression. Because the pathogenesis of AMD is multifactorial, ways need to be developed to make informed decisions about the most efficacious intervention for individual patients or patient subgroups. The studies in this application will test the hypothesis that mitochondrial dysfunction is a key step in AMD pathology for individuals harboring the AMD high risk SNP (rs1061170; amino acid change Y402H) for complement factor H (CFH), the most prevalent AMD patient population and the one with the greatest risk for developing advanced disease.

PI_NAMEs: DUTTON, JAMES R.;FERRINGTON, DEBORAH ANN (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: advanced disease;Affect;Aftercare;age difference;Age related macular degeneration;Alternative Complement Pathway;Amino Acids;Biochemical;Bioinformatics;biological adaptation to stress;Biological Assay;Biological Models;Blindness;Cells;Chronic;Collection;Complement;Complement Activation;Complement Factor H;Coupled;Data;Defect;Development;Disease;disease phenotype;efficacious intervention;Epidemic;Exhibits;extracellular;Functional disorder;functional outcomes;Funding;Genes;Genetic Polymorphism;Genotype;Goals;Health;high risk;high risk population;Histidine;Homeostasis;immunoregulation;Individual;individual patient;induced pluripotent stem cell;Inflammation;insight;Investigation;Knowledge;Link;Measures;Metabolic;metabolome;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;new therapeutic target;novel;older adult;Oxygen Consumption;Parents;Pathogenesis;Pathology;Pathway interactions;patient population;patient subsets;Patients;personalized medicine;Phenotype;Population;Positioning Attribute;Prevalence;prevent;Process;Proteins;Proteome;Publishing;Respiration;response;Risk;risk variant;Role;Severity of illness;Single Nucleotide Polymorphism;Stress;stressor;Structure of retinal pigment epithelium;targeted treatment;Testing;therapy development;Tyrosine;Variant;Work

PROJECT_TITLE: Mitochondrial defects in the retinal pigment epithelium and the CFH risk allele for age-related macular degeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: ES

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Public Health Statement / Narrative The Duke University Superfund Research Center (DUSRC) will study the impacts of multiple contaminant exposures in humans and ecological models of neurodevelopmental health, elucidate neurotoxic mechanisms that occur from these co-exposures, and develop novel remediation and treatment strategies that target the highest risk contaminants without increasing the risk of other contaminants. Our work will provide key data and information needed to improve public health guidance and environmental clean-up goals to effectively mitigate the negative health consequences of co-exposure to hazardous chemicals.

PI_NAMEs: STAPLETON, HEATHER M (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: Address;Adolescence;behavior measurement;Businesses;Child;Cognitive;cohort;Communication;Communities;community empowerment;community engagement;Complex;Data;Development;developmental toxicity;doctoral student;drinking water;early life exposure;Encapsulated;Engineering;Environment;Environmental Engineering technology;Environmental Health;Environmental Science;Epidemiologist;Evaluation;experience;exposure pathway;Exposure to;Flame Retardants;Gasoline;Goals;Hazardous Chemicals;Hazardous Substances;Health;health disparity;high risk;Home;Home environment;Human;improved;In Vitro;in vivo;Interdisciplinary Study;Investigation;Investments;Knowledge;late life;Lead;lead exposure;Life;Local Government;Measures;member;Metal exposure;Metals;Methods;microbiome;Modeling;National Institute of Environmental Health Sciences;neglect;neurobehavioral;neurodevelopment;neurotoxic;next generation;Nongovernmental Organizations;novel;Outcome;Paint;people of color;Pesticides;Population Heterogeneity;Postdoctoral Fellow;Pregnancy;prenatal;prevent;programs;Prospective cohort;Public Health;Recommendation;remediation;Research;Resources;Risk;Risk Assessment;Risk Reduction;Scientist;Signal Recognition Particle;Site;skills;Soil;Source;stable isotope;State Government;Strategic Planning;Superfund;System;Techniques;Technology;Toxic effect;Training;translational engagement;Translational Research;treatment strategy;United States;Universities;Work

PROJECT_TITLE: Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lead Poisoning;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health

PHR: Project Narrative Perinatal exposure to lead is known to adversely impact neurodevelopment; however, children are exposed to lead in combination with many other hazardous chemicals that may interact to negatively impact neurodevelopment. This project will examine the role of prenatal co-exposure to metals and polycyclic aromatic hydrocarbons (PAHs) to assess their interactive effect on neurodevelopment in children. Additionally, we will use a novel isotopic approach to identify the primary sources of lead exposure in an impacted community and recommend the best mitigation strategies to reduce exposure and health risks.

PROJECT_TERMS: Abate;Address;Age;Area;Aromatic Polycyclic Hydrocarbons;Assessment tool;Awareness;Behavior assessment;Behavioral;Blood;blood lead;Blood specimen;burden of illness;Cadmium;Chemicals;Child;Childhood;Chronic;Clinical assessments;Clupeidae;Cognitive;cognitive testing;cohort;Communities;Complex;Data;Development;developmental neurotoxicity;Dose;drinking water;economic impact;Effectiveness;Environmental Health;Epidemiologist;experimental study;exposure pathway;Exposure to;fetal lead exposure;First Pregnancy Trimester;Follow-Up Studies;geochemistry;Geographic Locations;Goals;Hazardous Chemicals;Hazardous Substances;Health;health disparity;House Dust;Human;indoor dust;Industrialization;insight;Isotopes;Lead;lead exposure;Life;Longitudinal Studies;Measures;Metal exposure;Metals;Methods;Monitor;multidisciplinary;neurodevelopment;Neurotoxins;novel;organic contaminant;Outcome;Parents;Participant;Pathway interactions;Pattern;Perinatal Exposure;Persons;Population;Pregnancy;Pregnancy Trimesters;Pregnant Women;prenatal;Prenatal care;prenatal exposure;Recommendation;Recontacts;remediation;Research;Research Personnel;Resolution;Resources;Risk;Role;Sampling;Scientist;Silicones;Site;sleep pattern;Smoking;Soil;soil lead;Source;source localization;Subgroup;success;Superfund;superfund site;Surface;Techniques;Third Pregnancy Trimester;Toxicology;Trace metal;Tracer;Universities;Visit;Woman;wristband

PROJECT_TITLE: Project 1: Prenatal Exposures to PAHs and Metals in an Impacted Community: Assessing Neurodevelopment Impacts and Tracing Metal Sources


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: ROOTSTOWN

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NORTHEAST OHIO MEDICAL UNIVERSITY

ORG_STATE: OH

PHR: Takotsubo Syndrome is a condition characterized by regional cardiac dysfunction, which was originally considered innocuous. These thoughts were revised because of observations showing similar mortality in patients with Takotsubo Syndrome to other acute coronary syndromes. Our proposal is directed at understanding regional differences in the control of myocardial blood flow and cardiac metabolism underlying Takotsubo Syndrome.

PI_NAMEs: CHILIAN, WILLIAM M (contact);DONG, FENG

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Abate;acute coronary syndrome;Agreement;Apex of the Heart;Apical;Area;arteriole;base;Blood flow;Cardiac Myocytes;Cell Death;Clinical;Complex;Contrast Echocardiography;contrast enhanced computed tomography;Coronary;Coronary Occlusions;Coronary Vessel Anomalies;Development;Down-Regulation;Drug usage;Echocardiography;Event;fatty acid metabolism;Gene Expression;Glucose;Heart;heart function;heart metabolism;hemodynamics;Hibernation;Hypoxia;Image;Impairment;improved;Injury;interdisciplinary approach;Ischemia;Laboratories;Left;Left ventricular structure;Maps;Mass Spectrum Analysis;Measurement;Medical;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;Microcirculation;Mind;Mitochondria;Modeling;Molecular;mortality;mouse model;multiphoton imaging;Myocardial;Myocardial dysfunction;Myocardial Hibernation;Myocardial Ischemia;Necrosis;necrotic tissue;Ohio;Oxygen Consumption;Patients;Phenotype;Phosphorylation;Play;prevent;Process;programs;protein expression;Reaction;Recovery;regional difference;Regulation;Research;restoration;Reverse Transcriptase Polymerase Chain Reaction;RNA;Role;Scientist;Smooth Muscle;Stress;Stress cardiomyopathy;Syndrome;Technology;Testing;Thinking;Time;Tissues;transcriptome sequencing;Transgenic Model;Translations;two-photon;Universities;Vasoconstrictor Agents;Vasodilation;Vasodilator Agents;Ventricular;Western Blotting

PROJECT_TITLE: Mechanisms Underlying Takotsubo Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C(02)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Endocrine Disruptors;Mental Health;Neurosciences;Prevention

PHR: Project Narrative Our project, “Persisting Neurobehavioral Dysfunction Caused by Interacting Toxicant Exposures During Development: Mechanistic and Treatment Studies with Zebrafish and Rats”, will determine in zebrafish and rats the persisting neurobehavioral effects of chronic developmental exposure to polyaromatic hydrocarbons and heavy metals. The studies will help determine the extent of the adverse effect, mechanisms for those effects and treatments to avoid or reverse the adverse effects.

PI_NAMEs: LEVIN, EDWARD D (contact)

PROJECT_TERMS: Acetylcholine;Address;Adolescent;Adult;Adverse effects;Analytical Chemistry;Anti-Inflammatory Agents;Antioxidants;Aromatic Polycyclic Hydrocarbons;Attenuated;Back;Behavioral;behavioral impairment;Benzo(a)pyrene;Biological;biological adaptation to stress;Biological Assay;Budgets;Cadmium;Chemicals;Chronic;Cognitive deficits;cognitive function;Collaborations;Communication;Communities;community engagement;Complex;Complex Mixtures;cytokine;Data;Data Analyses;data management;Development;developmental neurotoxicity;Developmental Toxicant;DNA Methylation;Dopamine;Dose;efficacy evaluation;efficacy testing;Emotional;emotional functioning;Epigenetic Process;Evaluation;Exposure to;fluoranthene;Functional disorder;Hazardous Substances;Health;Heavy Metals;Hippocampus;Human;Impaired cognition;Impairment;improved;Individual;Inflammatory;Inflammatory Response;Interleukin-1 beta;Investigation;Lead;Mammals;Mediating;Metal exposure;Metals;Methods;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Motility;Motor;Motor Activity;neural;neurobehavioral;neurobehavioral test;neurotoxic;neurotoxicity;Neurotoxins;Neurotransmitters;novel strategies;Outcome;Oxidative Stress;Persons;Pharmaceutical Preparations;prevent;Process;prototype;Rattus;remediation;Research;response;Risk;Risk Assessment;Rodent Model;Role;screening;Serotonin;sex;Sex Differences;Societies;Statistical Data Interpretation;Superfund;System;Techniques;Testing;Therapeutic;therapy development;Toxic effect;Toxic Environmental Substances;toxicant;Toxicant exposure;toxicant interaction;Translational Research;Universities;Zebrafish

PROJECT_TITLE: Project 2: Persisting Neurobehavioral Dysfunction Caused by Interacting Toxicant Exposures During Development: Mechanistic and Treatment Studies with Zebrafish and Rats


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PI_NAMEs: BUSH, MATTHEW LEE;KELLY, THOMAS H. (contact)

PROGRAM_OFFICER_NAME: DOYLE, JAMIE MIHOKO

PROJECT_TERMS: Acceleration;Address;Arts;biomedical informatics;Biomedical Research;career;career development;Clinical;clinical center;Clinical Research;Clinical Sciences;cohort;college;Communities;Competence;Complex;Dentistry;design;Discipline;Discipline of Nursing;Education;Educational Curriculum;Educational Technology;Elderly;Engineering;experience;Extramural Activities;Faculty;Foundations;Funding;Future;Growth;Health;Health Sciences;Human;improved;Individual;Institution;instructor;interest;Kentucky;Leadership;life span;Medical Students;Medicine;Mentors;Monitor;multidisciplinary;next generation;Pharmacy facility;Policies;prenatal;Principal Investigator;Process;programs;Public Health;Publishing;Research;research and development;Research Methodology;Research Training;Science;skills;Time;Training;Training Programs;Training Support;Translational Research;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities

PROJECT_TITLE: Institutional Career Development Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

PI_NAMEs: RUSSELL, DAVID G (contact)

PROJECT_TERMS: Animal Model;Animals;Antibiotics;axenic culture;Bacteria;Bacterial Genes;Biological Models;Biology;Bronchoalveolar Lavage;candidate identification;Cell Line;Cell model;Cell Separation;Cells;Clinical;clinically relevant;Collecting Cell;CRISPR/Cas technology;Development;drug efficacy;Drug Exposure;Drug resistance;Drug Tolerance;Environment;gene editing technology;Genetic;Genetic Databases;Genetic Engineering;genetic manipulation;Genome engineering;global health;Goals;Heritability;Heterogeneity;Human;human disease;Immune;in vivo;Infection;Link;Lung;Macrophage;Messenger RNA;Metabolic;Metabolic Pathway;Metabolism;Modality;Modeling;Mus;Mutation;Mycobacterium tuberculosis;network models;novel therapeutic intervention;Outcome;pathogen;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiology;Population;Property;rational design;Regimen;Resistance;Resources;Route;single-cell RNA sequencing;Small Interfering RNA;Specimen;success;System;Systems Biology;Testing;Therapeutic;Therapeutic Intervention;therapeutic siRNA;tool;transcriptome;transcriptome sequencing;Tuberculosis;tuberculosis chemotherapy;tuberculosis drugs

PROJECT_TITLE: Minimizing in vivo Drug Tolerance induction in tuberculosis.


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cardiovascular;Emerging Infectious Diseases;Heart Disease;Infectious Diseases;Women's Health Research

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE There is currently no clear understanding of why an enterovirus like coxsackievirus, that typically targets the gut, would cause myocarditis leading to heart failure. This project will examine whether the ability of coxsackievirus to replicate in the mitochondria of cardiac cells leads to sex differences in myocardial inflammation.

PI_NAMEs: FAIRWEATHER, DELISA  (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Adult;Age;Animal Model;Autophagosome;Autopsy;Bioenergetics;Biogenesis;Biopsy;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cell Communication;Cells;Child;Complex;COVID-19 patient;Coxsackie Viruses;Data;Diagnosis;Dilated Cardiomyopathy;Disease;Disparate;Enterovirus;ESR1 gene;estrogenic;extracellular vesicles;Female;Goals;Heart;heart damage;Heart failure;Heart Transplantation;Hepatitis C virus;HIV;Homeostasis;Human poliovirus;Immune response;Incidence;Infection;Inflammation;Inflammatory;Influenza A virus;Ingestion;Inner mitochondrial membrane;Lytic;Macrophage;male;Mediating;men;MicroRNAs;Mitochondria;Mitochondrial Proteins;Mus;Myelogenous;Myeloid Cells;Myocardial;Myocarditis;Myocardium;novel;Outer Mitochondrial Membrane;Parkin;Patients;Phosphorylation;Proteins;Proteomics;Publishing;Reporting;response;Risk;Role;Severities;sex;Sex Differences;Signal Transduction;Structure;Sudden Death;Time;TLR4 gene;Transcript;transcriptome sequencing;Tropism;Viral;Viral Proteins;Virus;Virus Diseases;Virus Replication;Woman

PROJECT_TITLE: Role of mitochondrial extracellular vesicles in CVB3 myocarditis by sex

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: Project Narrative Exposure of the developing nervous system to environmental contaminants can have life-long effects, as illustrated by a few well-known examples such as lead. The degree to which combined exposures to multiple chemicals can adversely impact neurodevelopment is very poorly understood, although people are invariably exposed to mixtures, not single compounds. We will test the developmental neurotoxicity of combined exposures to common and important pollutants in order to provide information and a new cost- and time- efficient tool that could be used with real-life complex mixtures to test whether current regulatory actions at Superfund sites are adequate for protecting against adverse impacts on the developing nervous system.

PI_NAMEs: MEYER, JOEL NEWMAN (contact)

PROJECT_TERMS: adverse outcome;Affect;Architecture;Aromatic Polycyclic Hydrocarbons;Behavior;Behavioral;Bioenergetics;biological adaptation to stress;Cadmium;Caenorhabditis elegans;Calibration;Cell Physiology;cell type;Cells;Chemical Exposure;Chemicals;Collaborations;Complex;Complex Mixtures;cost;Development;developmental neurotoxicity;early life exposure;Economic Models;Embryo;Environment;environmental justice;Environmental Pollutants;Epigenetic Process;experimental study;Exposure to;Female;Fishes;follow-up;Future;Hazardous Chemicals;Homeostasis;Human;improved;In Vitro;in vivo;Individual;Intervention;Laboratories;late life;Lead;Life;macromolecule;male;Maps;Measures;Mediating;Mission;Mitochondria;mitochondrial dysfunction;Modeling;Modification;Molecular;Molecular Target;Morphology;Nerve Degeneration;nerve stem cell;Nervous System;neurodevelopment;neurogenesis;Neurons;neurotoxic;neurotoxicity;neurotoxicology;Neurotoxins;novel;Outcome;Oxidation-Reduction;Pathway interactions;Pattern;Persons;pharmacologic;Physiological;Policies;pollutant;Predisposition;Production;Rattus;Regulation;remediation;Research;resilience;Secondary to;sex;Sex Differences;Stress;Structure;Superfund;superfund chemical;superfund site;System;Testing;Time;tool;Toxic effect;toxicant;Universities;Variant;Work

PROJECT_TITLE: Project 3: Mitochondrial and cellular mechanisms of neurotoxicity of Superfund chemical co-exposures


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products

ORG_CITY: CAMBRIDGE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE  Enzymes are essential for the metabolic processes that occur throughout nature, but we still have an incomplete understanding of the full repertoire of enzyme families that can participate within metabolism. Recently, we have found that carbonic anhydrase (CAH) family enzymes with key active site mutations have neofunctionalized to act in the biosynthesis of neuroactive molecules in plants, and strikingly, similar mutations can be found in the evolutionarily-conserved carbonic anhydrase related proteins (CARPs) that are important for neurological function in humans. Our research will provide fundamental insight on the catalytic mechanisms and metabolic capabilities of neofunctionalized CAH enzymes, with an emphasis on a) CAHs that participate in the biosynthesis of medicinal compounds in plants, and b) CARPs that are critical for neurobiology in humans and other animals.

PI_NAMEs: NETT, RYAN STEPHAN (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Investigating neofunctionalized alpha-carbonic anhydrases as an emerging class of biosynthetic enzyme in plant and animal metabolism

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Endocrine Disruptors;Microbiome;Neurosciences;Social Determinants of Health

PHR: Project Narrative Exposure chemical contaminants in aquatic ecosystems can have significant ecologically relevant fitness consequences such as mitochondrial dysfunction linked to adverse behavioral and bioenergetic outcomes. These effects may be exacerbated when exposed to multiple abiotic stressors such as changes in temperature and oxygen levels, but remain poorly understood. We will determine physiological fitness outcomes of chemical exposure in a multi-stressor environment in the context of evolved pollution resistance to better inform ecological risk assessment.

PI_NAMEs: JAYASUNDARA, NISHAD  (contact)

PROJECT_TERMS: Address;Adolescent;Analytical Chemistry;Animals;Area;Aromatic Polycyclic Hydrocarbons;Basic Science;Behavior;Behavioral;Behavioral Assay;behavioral study;Bioenergetics;Biological;Biological Assay;Cadmium;Chemical Exposure;Chemicals;Collaborations;Communities;community engagement;contaminated fish;Cytochrome P450;Data Analyses;data management;Development;early life exposure;Ecosystem;Effectiveness;Embryo;Embryonic Development;Environment;Environmental Health;Environmental Impact;Environmental Pollutants;Epidemiology;Epigenetic Process;experience;Experimental Designs;Exposure to;Fishes;fitness;functional genomics;Fundulus heteroclitus;Generations;Germ-Free;Goals;graduate student;gut microbiome;Habitats;Hazardous Chemicals;Health;Heavy Metals;Hybrids;Hypoxia;Impairment;indexing;Killifishes;Knowledge;Larva;late life;Lead;lead exposure;Life;Link;Measures;Mediating;Metal exposure;metal poisoning;Metals;Methylation;methylome;microbial;microbiome composition;Mitochondria;mitochondrial dysfunction;Modification;Molecular;neurobehavioral;neurotoxicity;Neurotransmitters;novel;Organism;Outcome;Oxygen;Parents;Performance;Physiological;Pollution;Population;Postdoctoral Fellow;Predisposition;programs;Progress Reports;Recording of previous events;remediation;Research;Research Design;Research Personnel;Resistance;response;Risk Assessment;Role;Sampling;Signal Transduction;Site;Stress;stressor;Superfund;superfund site;Swimming;Temperature;Toxic effect;Toxicology;Training;training opportunity;transcriptome;Translational Research;Universities;Wood material;Work

PROJECT_TITLE: Project 4: Neurobehavioral and bioenergetic consequences of evolving resistance to polycyclic aromatic hydrocarbons in a multi-stressor environment


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Rare Diseases;Tuberculosis

PI_NAMEs: SHERMAN, DAVID R (contact)

PROJECT_TERMS: Adherence;Affect;Bacillus;Biological;Biological Assay;Biological Markers;Cells;Characteristics;Clinical;Code;Collection;cost;data integration;Development;Disease;DNA;Drug Combinations;Drug resistance;Drug Tolerance;Environment;Evaluation;Evolution;Frameshift Mutation;Frequencies;gene complementation;Gene Expression;gene network;Genes;Genetic;genetic predictors;genetic resistance;Genetic Screening;Genetic Transcription;genomic locus;Genus Mycobacterium;Growth;Heterogeneity;Immune;Immunity;improved;innovation;Knock-out;Laboratories;Length;Libraries;Link;Machine Learning;Metabolic;metabolomics;Microscopy;mutant;Mycobacterium tuberculosis;network models;novel;Outcome;Pathway Analysis;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phenotype;Population;Population Heterogeneity;Predisposition;Proteins;Public Health;Regulon;Relapse;Resistance;resistance mechanism;response;Robotics;Role;success;System;Systems Biology;Testing;Therapeutic;Time;tool;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;treatment duration;Treatment Failure;Treatment outcome;Tuberculosis;tuberculosis chemotherapy;tuberculosis drugs;tuberculosis treatment;Variant;Work

PROJECT_TITLE: Drug tolerance, bacterial heterogeneity and adverse TB treatment outcomes


PHR: Project Narrative Polycyclic aromatic hydrocarbons (PAHs) are contaminants of great concern commonly encountered at Superfund sites. In this project, we will develop innovative precision bioremediation approaches that promote PAH degradation and minimize co-contaminant mobilization. A fundamental feature of our project will be the engineering of microcapsule delivery vehicles that facilitate targeted delivery and optimized activity of microbes carrying out key remediation functions, ultimately reducing the potential for human and environmental exposure.

PI_NAMEs: GUNSCH, CLAUDIA KNELLER (contact)

PROJECT_TERMS: Address;Amendment;Analytical Chemistry;Aromatic Polycyclic Hydrocarbons;Bacteria;Biodegradation;Biological Availability;Biomanufacturing;Bioremediations;Budgets;Carbon;carcinogenicity;Characteristics;Chemicals;Collaborations;Communication;Communities;community collaboration;community engagement;Complex;Data;Data Analyses;data management;delivery vehicle;Development;Ecosystem;Effectiveness;Encapsulated;Engineering;Environment;Environmental Exposure;Environmental Impact;Evaluation;Excision;experience;exposed human population;Exposure to;fitness;Funding;fungus;geochemistry;Goals;Growth;Hydrophobicity;improved;In Situ;In Vitro;in vivo;Industry;innovation;Killifishes;Libraries;member;Metals;Methods;Microbe;microbial;microbiome;microbiota;Microcapsules drug delivery system;microorganism interaction;Mitochondria;Multiprotein Complexes;neurobehavioral;Organism;Outcome;Permeability;Property;Proteins;remediation;Research;Research Personnel;Resort;risk minimization;Running;Site;Soil;Statistical Data Interpretation;Superfund;superfund site;System;targeted delivery;Technology;Toxic effect;toxic metal;Training;Translational Research;Universities;Work

PROJECT_TITLE: Project 5: Microencapsulation Delivery Vehicles for the Implementation of Precision Bioremediation at PAH-Contaminated Superfund Sites


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Anxiety disorders are the most common class of psychopathology among youth, with nearly a quarter of adolescents meeting 12-month diagnostic criteria. The primary aim of this project is to use user-centered design methods to engage at-risk adolescents, providers, and community partnerships into the design and evaluation of a technology-enabled prevention service for anxiety. Accomplishment of the training goals and proposed research project will provide the skills and tools necessary for development of an R01 proposal aimed at testing the efficacy of the technology-enabled prevention service for anxiety among youth within community settings.

PI_NAMEs: KNAPP, ASHLEY AREHART (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;Adult;Anxiety;Anxiety Disorders;anxiety symptoms;Aptitude;Automobile Driving;career;career development;Caring;childhood anxiety;Cognitive;Communities;community engaged research;community organizations;community partners;community partnership;community setting;Complement;computer human interaction;Data Analytics;design;Development;diagnostic criteria;digital mental health;digital technology;digital tool;Disease;Educational workshop;efficacy evaluation;efficacy testing;emotion dysregulation;Evaluation;evidence base;Experimental Designs;Feedback;Functional impairment;Generations;Goals;Grant;Health;Immersion;Incidence;Infrastructure;Intervention;intervention effect;iterative design;Laboratories;Literature;Mediating;meetings;Mental Depression;Mental Health Services;Mentored Research Scientist Development Award;Mentorship;Methodology;Methods;novel strategies;Outcome;Performance;physical conditioning;pilot trial;Population;prevent;Prevention program;prevention service;Preventive healthcare;preventive intervention;Process;programs;prototype;Provider;psychologic;Psychopathology;Randomized;Research;Research Project Grants;Risk;school health;Scientist;Services;skills;social relationships;software development;substance use;System;Technology;Teenagers;Testing;testing services;tool;Training;Training Programs;Translating;underserved community;Underserved Population;usability;user centered design;Work;Youth

PROJECT_TITLE: Technology-Enabled Prevention Service for At-Risk Youth

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Defective human mismatch repair (MMR) genes cause the common cancer susceptibility Lynch syndrome aka hereditary non-polyposis colorectal cancer (LS/HNPCC), as well as 10-40% of various sporadic cancers. This proposal will utilize novel single molecule imaging techniques to quantitatively examine the mechanisms of human MMR in vitro and in vivo. Understanding the detailed MMR sequences responsible for faithful repair, DNA damage sensing, immune activation and cancer should significantly advance predictive genetic diagnostics for LS/HNPCC patients and therapeutic strategies for tumors driven by MMR defects.

PI_NAMEs: FISHEL, RICHARD  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Address;Automobile Driving;Binding;Biochemical;biophysical analysis;Biophysics;cancer immunotherapy;carcinogenesis;Cells;Chromatin;Chromatin Modeling;Chromosomes;Clinical;Closure by clamp;colon cancer patients;Complex;Defect;design;Diagnostic;Diffusion;DNA;DNA Damage;DNA Repair;DNA Sequence;DNA-Directed DNA Polymerase;Drug resistance;endonuclease;Event;Excision;Excision Repair;exodeoxyribonuclease;Flap Endonucleases;Funding;gene repair;Genes;genetic predictors;Genetic Recombination;Genomic Instability;Genomics;Goals;Hereditary Nonpolyposis Colorectal Neoplasms;Homologous Gene;Homologous Protein;Human;human pluripotent stem cell;imaging capabilities;Imaging Device;imaging modality;Imaging Techniques;immune activation;Immunotherapy;In Vitro;in vivo;Lead;Lesion;Link;Malignant Neoplasms;Mechanics;Mediator;Mismatch Repair;Mismatch Repair Deficiency;MLH1 gene;Modeling;Motion;MSH2 gene;MSH6 gene;Mutate;Mutation;Natural Immunity;Nature;novel;Nucleosomes;Pathway interactions;PD-1/PD-L1;Pharmaceutical Preparations;PMS2 gene;Polymerase;Predisposition;Process;Property;Proteins;Reaction;reconstitution;repair model;repaired;Research;Resistance;Resolution;response;sensor;Signal Transduction;single molecule;Single-Stranded DNA;Slide;SS DNA BP;System;Testing;Therapeutic;Time;TOPBP1 Gene;TREX1 gene;tumor;tumorigenesis;Visualization

PROJECT_TITLE: Mismatch Repair and Carcinogenesis


PHR: Project Narrative The Administrative and Research Translation Core (ARTC) of the Duke University Superfund Research Center (DUSRC) provides holistic support to the Center’s five research projects and four cores. Through efficient central planning and coordination, fiscal oversight, stakeholder and partnership engagement, effective communication and trainee support, the ARTC will enable an integrated and efficient systems approach to research, and successful research translation. Annual milestones and measurement of success metrics will enable the ARTC to refine and adapt its approach to Center management, ensuring DUSRC objectives are met.

PROJECT_TERMS: Acceleration;Address;Administrator;Advisory Committees;Analytical Chemistry;Appropriateness Review;Area;Chalk;Collaborations;Communication;Communities;community collaboration;community engagement;Coupled;Coupling;Data;Data Analyses;Data Collection;data management;Databases;Development;Doctor of Philosophy;Educational workshop;Ensure;Environment;Environmental Health;Evaluation;Event;experience;Exposure to;Fostering;Funding;Goals;Government;graduate student;Grant;Health Personnel;Institution;Investigation;late life;Leadership;Life;Measurement;meetings;Metals;Mission;Monitor;National Institute of Environmental Health Sciences;Nature;online resource;organizational structure;Outcome;Postdoctoral Fellow;Production;Public Health;Regulation;remediation;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Research Technics;Resources;Role;Schedule;Science;Scientist;Signal Recognition Particle;Structure;Students;success;Superfund;symposium;System;Technology Transfer;Training;translational engagement;Translational Research;United States National Institutes of Health;Universities;Update


NIH_SPENDING_CATS: Bioengineering;Endocrine Disruptors;Health Effects of Indoor Air Pollution

PHR: Project Narrative Assessment of health impacts related to human or ecological exposure to pollutant chemicals relies critically on our ability to measure these chemical species at relevant levels in biological and environmental samples. Superfund contaminants such as hydrophobic organic contaminants (e.g. polycyclic aromatic hydrocarbons) and metals (e.g. lead, cadmium) must be measured with high sensitivity and selectivity. The Analytical Chemistry Core seeks to provide these capabilities, along with training and expert consulting services in analytical chemistry practice, to researchers probing developmental impacts of Superfund-relevant chemicals after environmentally- relevant exposures.

PI_NAMEs: FERGUSON, P. LEE (contact)

PROJECT_TERMS: Analytical Chemistry;analytical method;Aromatic Polycyclic Hydrocarbons;Arsenic;Biodegradation;Biological;Biological Markers;Body Burden;Cadmium;Chemicals;Chromium;Collaborations;Complex;Complex Mixtures;cost;Data;Data Analyses;Development;developmental toxicity;Dose;early life exposure;Ecosystem;effectiveness evaluation;Engineering;Environment;Evaluation;experience;Experimental Designs;Exposure to;Flame Retardants;Funding;hands on instruction;Hazardous Substances;Health;health assessment;High Pressure Liquid Chromatography;House Dust;Human;Human Resources;Hydrophobicity;Hydroxylation;Inductively Coupled Plasma Mass Spectrometry;Instruction;instrument;instrumentation;interest;Laboratory Research;Lead;Life;Liquid Chromatography;Mass Fragmentography;Mass Spectrum Analysis;Measurement;Measures;Mercury;Metabolic;Metals;Methods;Monitor;Neurotransmitters;novel;Organic Chemicals;organic contaminant;Organophosphates;Outcome;Pentachlorophenol;Pesticides;pollutant;Poly-fluoroalkyl substances;Polychlorinated Biphenyls;Preparation;Protocols documentation;remediation;Research;Research Activity;Research Personnel;Research Project Grants;Resolution;Resources;Role;Sampling;Schedule;Selenium;service utilization;Services;success;Superfund;superfund chemical;superfund site;tandem mass spectrometry;Techniques;Technology;Testing;Tissues;Toxic effect;Trace metal;Training;Universities

PROJECT_TITLE: Analytical Chemistry Core (ACC)


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE Adenovirus is the most common cause of human eye infection, and yet, at present there is no effective therapy. We will study three novel interfaces during viral infection of corneal epithelial and stroma cells with the potential to increase understanding of viral pathogenesis. Studies on intracellular viral trafficking and virion assembly may lead to novel approaches to antiviral therapies, while our examination of how corneal epithelial cell-derived proinflammatory mediators contribute to corneal inflammation is directly translatable to the keratitis caused by adenovirus infection in the human cornea.

PI_NAMEs: CHODOSH, JAMES ;RAJAIYA, JAYA  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;Accounting;acute infection;Adenosine;Adenovirus Infections;Adenoviruses;Anti-viral Therapy;ATP phosphohydrolase;Binding;Binding Proteins;Biological Assay;Capsid;Capsid Proteins;caveolin 1;Cell Nucleus;cell stroma;cell type;Cells;Cementation;Chemotaxis;Chronic;Clathrin;Clinical;Co-Immunoprecipitations;Complex;confocal imaging;Confocal Microscopy;Conjunctivitis;Cornea;corneal epithelium;Corneal Stroma;cost;Cytoplasm;design;Disparate;effective therapy;Electron Microscopy;Endosomes;Epidemic Keratoconjunctivitis;Epithelial Cells;Epithelium;Event;experimental study;Eye Infections;Fibroblasts;Future;Gene Expression;Goals;HMGB1 gene;Human;Image;imaging approach;Immune response;In Vitro;in vivo;Infection;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Innate Immune Response;Keratitis;Kinesin;Kinetics;knock-down;Label;Leucocytic infiltrate;Leukocytes;Link;Liquid Chromatography;Mediating;Membrane Microdomains;Microtubules;migration;Minor;Modeling;Morbidity - disease rate;mutant;novel;novel strategies;Nuclear;Nuclear Localization Signal;Nuclear Pore Complex Proteins;Nuclear Translocation;nucleocytoplasmic transport;ocular surface;Office Visits;pathogen;Pathogenesis;Pathway interactions;penton base;Peptide Hydrolases;Persons;Phosphorylation;Photophobia;Play;Primary Care;Proteins;Proteomics;Proton Pump;Publishing;Recurrence;Role;Signal Pathway;Signal Transduction;Small Interfering RNA;Surface Plasmon Resonance;tandem mass spectrometry;Testing;Therapeutic;trafficking;Translating;Ubiquitin;United States;Viral;viral DNA;Viral Genes;Viral Pathogenesis;Viral Proteins;Viral Structural Proteins;Virion;Virulent;Virus;Virus Diseases;Virus Replication;Visual impairment;Western Blotting;Work

PROJECT_TITLE: Novel Mechanisms in Adenoviral Ocular Pathogenesis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


PHR: Project Narrative Environmental health science problems posed by chemical exposure are complex; addressing these problems successfully requires expertise from diverse scientific fields. Likewise, communicating science is challenging for many scientists, and historically much environmental health science work has been done in the absence of interaction with affected communities. The Research Experience and Training Coordination Core of the Duke University Superfund Research Center is dedicated to training future environmental health researchers from many backgrounds in a cross-disciplinary fashion that enables them to carry out and communicate integrated, problem-oriented research, in partnership with affected communities.

PROJECT_TERMS: Address;Affect;Area;Award;base;career;career development;Chemical Exposure;Chemicals;Collaborations;Communication;Communities;community engagement;community research;Complement;Complex;Data Analyses;data management;Dedications;design;Development;Discipline;doctoral student;early life exposure;Engineering;Ensure;Environment;Environmental Engineering technology;Environmental Health;environmental justice;Environmental Science;experience;Faculty;flexibility;Funding;Future;Goals;graduate student;Individual;Knowledge;late life;Link;member;Mentors;Minority;Outcome;Postdoctoral Fellow;Problem Solving;Program Evaluation;programs;Publications;recruit;remediation;Research;Research Personnel;Research Training;Resources;Science;Scientist;Site;skills;social;Solid;Specificity;Structure;Students;success;Superfund;superfund site;System;Time;Training;Training Activity;Translating;translational engagement;Translational Research;undergraduate student;Underrepresented Minority;Universities;Work

PROJECT_TITLE: Research Experience and Training Coordination Core (RETCC)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PHR: Project Narrative Supporting the aim articulated in NIEHS’s 2018-2023 strategic plan to “recognize and seek to address the disparate health impacts of environmental hazards on disadvantaged and diverse communities,” and the focus of the Duke University Superfund Research Center (DUSRC) to investigate neurodevelopmental health impacts of early-life co-exposures to polycyclic aromatic hydrocarbons (PAHs) and metals, the Community Engagement Core (CEC) will engage with low socioeconomic status communities of color in Durham and Navassa, North Carolina, experiencing disproportionate exposure due to geographic proximity to hazardous sites and expected exacerbated health risks from exposures due to social determinants of health1–10. The CEC’s holistic, three-tiered approach to prevention and intervention is based on the environmental health literacy framework11–14, with a focus on generating awareness of, and promoting self-efficacy to reduce exposure to chemical contaminants by facilitating bidirectional communication between affected communities and Center researchers and trainees, other SRPs and local, state and federal agencies. Co-produced in collaboration with our extensive network of community-based and community-serving organizations in the two geographic areas, the CEC aims to generate solutions to reduce early life exposure to PAHs and metals at the individual, community, and policy levels through the following approaches: 1) promote individual awareness and self-efficacy to reduce exposure among pregnant women and children in Durham, NC, through report-back and bidirectional communication mechanisms; 2) foster community level awareness of and the capacity to investigate and reduce exposures through co-developed Environmental Health Academies; and 3) build the capacity of affected communities to assess and utilize environmental health data to promote more effective and inclusive policies aimed at reducing exposure.

PI_NAMEs: SHAPIRO, ELIZABETH  (contact)

PROJECT_TERMS: Academy;Address;Affect;African American population;Analytical Chemistry;Aromatic Polycyclic Hydrocarbons;Articulation;Awareness;Back;Black race;Chemicals;Child;citizen science;cohort;Collaborations;Color;Communication;Communication Tools;Communities;Community Actions;community engagement;Community Networks;community partners;Complex;Data Analyses;data management;Decision Making;design;Development;Disadvantaged;early life exposure;empowerment;Ensure;Environmental Hazards;Environmental Health;Environmental Impact;Environmental Pollutants;experience;Exposure to;federal policy;Fostering;Geographic Locations;Geography;Hazardous Chemicals;Health;health data;health disparity;health literacy;Health Policy;Home;Individual;interest;Intervention;Latinx;Life;low socioeconomic status;member;Metals;Mission;National Institute of Environmental Health Sciences;North Carolina;Outcome;Participant;Policies;Pregnant Women;Prevention;Prevention approach;Process;programs;remediation;Reporting;Research;Research Personnel;Risk;Self Efficacy;Signal Recognition Particle;Site;social health determinants;Strategic Planning;Superfund;superfund site;Training;Translating;Translational Research;Universities;urban area

PROJECT_TITLE: Community Engagement Core (CEC)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD)

ORG_CITY: MADISON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The National Magnetic Resonance Facility at Madison (NMRFAM) research resource provides access to state- of-the-art solution and solid-state NMR technology to the biomedical research community, enabling facility users to leverage the power and diversity of NMR methods to study the structure, dynamics, function and interactions of large and small biomolecules. NMRFAM will continue to provide reliable and timely access to NMR instrumentation with excellent staff support for all phases of the NMR experience, in order to engage actively in experiment design well aligned with user objectives, to obtain the highest quality data possible and to commit to interpreting results to solve highly significant biomedical research problems that are best addressed by NMR.

PI_NAMEs: BUTCHER, SAMUEL E;HENZLER-WILDMAN, KATHERINE ANNE (contact);RIENSTRA, CHAD M

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;Adopted;Advisory Committees;Area;Automation;base;Biological;Biomedical Research;Biophysics;Calibration;Capital;Cell Nucleus;Collaborations;Communication;Communities;community engagement;Complex;Computer software;computerized data processing;Consult;Cryoelectron Microscopy;cryogenics;cyber security;Data;Data Analyses;Data Collection;data quality;Data Security;data sharing;Detection;Development;Doctor of Philosophy;Educational process of instructing;Educational workshop;Emerging Technologies;Ensure;experience;Experimental Designs;experimental study;FAIR principles;Goals;Helium;Home;Human Resources;Hybrids;improved;Individual;Infrastructure;Institution;instrument;instrumentation;interest;Isotopes;Knowledge;Ligands;Liquid substance;Magic;Magnetic Resonance;Maintenance;Membrane Proteins;metabolomics;Methods;Mission;Molecular Weight;National Center for Research Resources;National Institute of General Medical Sciences;Natural Products;next generation;NMR Spectroscopy;Nucleic Acids;operation;outreach;Performance;Pharmaceutical Preparations;Phase;Physiologic pulse;Procedures;programs;protein structure;Proteins;Protocols documentation;Quality Control;R24;Recovery;recruit;Recycling;repaired;Reproducibility;Research Support;Resources;Sampling;Schedule;Scientist;screening;Services;Site;solid state nuclear magnetic resonance;Standardization;structural biology;Structure;Surveys;System;Technology;Testing;Time;tool;Training;training opportunity;Tube;web server;Work;Writing

PROJECT_TITLE: NMR User Program at NMRFAM


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative The Data Management and Analysis Core (DMAC) works closely with all Center components to provide high quality data management and analysis in support of Center research goals of exploring developmental and later- life health effects of early life exposures to PAH’s and metals. The DMAC will work with projects and cores to make data FAIR, to implement reproducible research best practices, and to develop and deploy innovative tools to help external researchers and citizen scientists explore Center data and findings.

PI_NAMEs: HERRING, AMY H (contact)

PROJECT_TERMS: Address;Aloral;Analytical Chemistry;archived data;Archives;citizen science;Code;Collaborations;Communities;community engagement;Data;data access;Data Analyses;data archive;Data Collection;data integration;data integrity;data interoperability;data management;data quality;data resource;Data Science;data sharing;data visualization;design;Development;early life exposure;Ensure;Environment;Equipment and supply inventories;experience;Exposure to;FAIR principles;Fostering;Funding;Goals;Hazardous Substances;Health;innovation;insight;interest;late life;Leadership;Libraries;Link;Mentors;Metals;Methodology;Methods;National Institute of Environmental Health Sciences;novel;Ontology;Outcome;Policies;programs;PubMed;Quality Control;remediation;repository;Reproducibility;Research;Research Design;Research Personnel;Science;search engine;Semantics;Signal Recognition Particle;skills;sound;Statistical Data Interpretation;Superfund;tool;Training;Translational Research;United States National Institutes of Health;Universities;Visualization software;Work


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative / Lay Language Description Diarrheal disease accounts for an immense global public health burden, primarily among young children in low- resource settings. This project will test blood samples collected from young children enrolled in randomized trials in Kenya and Bangladesh for antibody response to diarrhea-causing pathogens so that we can study the effects of improved water, sanitation, handwashing, and nutrition on pathogen transmission, and determine whether serology can be used to identify communities with the highest burden of diarrhea-causing pathogens.

PI_NAMEs: ARNOLD, BENJAMIN F (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Adenoviruses;Age;Antibodies;Antibody Response;Antigens;arm;Ascaris;Bacteria;Bangladesh;Biological Assay;Biological Specimen Banks;Birth;Blood specimen;Blood Tests;burden of illness;Campylobacter;Campylobacter jejuni;Child;Cluster randomized trial;cohort;Communities;Complement;Control Groups;Country;Cryptosporidium;Cryptosporidium parvum;Data;Diarrhea;diarrheal disease;Dietary Intervention;disorder control;Enrollment;Ensure;Entamoeba histolytica;Enteral;enteric infection;enteric pathogen;enterotoxigenic Escherichia coli;environmental intervention;Epidemiologic Methods;Feces;Geography;Giardia;Growth;Handwashing;helminth infection;Helminths;Immunoglobulin G;improved;Infection;insight;Intervention;intervention effect;Intervention Studies;Kenya;Language;Legal patent;Maps;Measurement;Measures;Methods;Modeling;Molecular;Monitor;multiplex assay;Newborn Infant;Norovirus;nutrition;Outcome Measure;pathogen;pathogen exposure;Policies;Population;population based;Population Surveillance;Predisposition;Pregnant Women;Prevalence;primary endpoint;programs;prospective;Public Health;Randomized;randomized trial;Research;Research Project Grants;Resource-limited setting;response;Salmonella;Salmonella enterica;Sampling;Sanitation;Sapovirus;seroconversion;Serology;Serology test;Seroprevalences;serosurveillance;serosurvey;Soil;spatial epidemiology;Strongyloides;Testing;Time;transmission process;trial design;trial enrollment;Viral;Virus;Water;Work

PROJECT_TITLE: Serologic measures of enteric pathogen transmission for intervention studies and population monitoring in low-resource settings

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE Three-dimensional ultrasound imaging is an important clinical tool for disease diagnosis as well as providing guidance for interventional and surgical procedures. At present, existing three-dimensional ultrasound imaging technologies are not widely accessible, difficult to use, and do not provide sufficient imaging functionality to meet the clinical needs. To fill the gap, we propose to develop a new three-dimensional ultrasound imaging solution that is accessible, functional, user-friendly, low-cost, and compatible with most existing ultrasound imaging systems in the clinic.

PI_NAMEs: SONG, PENGFEI  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3-Dimensional;3D ultrasound;Ablation;Acoustics;Address;Adjuvant Chemotherapy;Adoption;Advanced Development;Anatomy;Area;Axillary lymph node group;Basic Science;Benchmarking;Benign;Biopsy;Blood;Blood flow;Breast Cancer Patient;Cardiology;Cellular Phone;Clinic;Clinical;clinical application;clinical imaging;Clinical Research;Clip;Code;cost;Data;Dependence;Development;Devices;Diagnosis;Diagnostic;Discipline of obstetrics;disease diagnosis;elastography;Equipment;Foundations;Frequencies;Gynecology;handheld equipment;Illinois;Image;imaging modality;imaging study;imaging system;Imaging technology;improved;in vivo;Intervention;Ionizing radiation;light weight;Malignant - descriptor;Malignant Breast Neoplasm;Marketing;Medical;Medical Device Designs;meetings;microsensor;microsystems;Motion;Neoadjuvant Therapy;non-invasive imaging;novel;Operative Surgical Procedures;Pathology;Patients;Performance;Phase;Play;portability;Procedures;radiologist;Radiology Specialty;Role;Scanning;Solid;Speed;superresolution imaging;System;Techniques;Technology;technology research and development;Texas;Three-Dimensional Imaging;Time;Tissues;tool;Training;Transducers;Ultrasonic Transducer;Ultrasonography;ultrasound;Universities;user-friendly;Visualization software;Water;wireless communication;Work

PROJECT_TITLE: A novel transducer clip-on device to enable accessible and functional 3D ultrasound imaging

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]