NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Substance Misuse

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Alcohol misuse is a major public health problem that results in thousands of annual arrests, assaults, injuries, alcohol use disorders and deaths, in both college and non-college young adults. Our past research has shown that wearable alcohol wrist sensors measuring the amount and manner in which alcohol is being consumed improve accuracy when combined with self-reported drink counts to predict consequences in natural settings. The proposed research greatly extends our past work using a multimodal, large-scale study to be the first to establish to what extent alcohol intake assessed by wearable alcohol wrist sensors can predict: 1) acute risk associated with single drinking events and 2) the development of alcohol use disorders.

PI_NAMEs: RUSSELL, MICHAEL ARTHUR (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: 20 year old;Acute;Address;Adult;Affect;Age;alcohol availability;alcohol consequences;Alcohol consumption;alcohol measurement;alcohol misuse;alcohol related consequences;alcohol use disorder;Alcoholic Intoxication;Alcohols;assault;Bacterial Artificial Chromosomes;binge drinker;binge drinking;Biosensor;Cessation of life;college;Consumption;Data;design;Development;drinking;drinking behavior;Event;experience;follow-up;Frequencies;Goals;Heavy Drinking;Impairment;improved;Individual;Injury;Intoxication;Link;Literature;longitudinal design;Measurement;Measures;meetings;middle age;multimodality;novel;Outcome;outcome prediction;Participant;Patient Self-Report;Pattern;prevent;prospective;prospective test;Protocols documentation;Public Health;Records;Reporting;Research;Research Design;Risk;Risk Assessment;Role;Sampling;Seasons;sensor;Severities;Symptoms;Testing;Time;wearable device;Work;Wrist;young adult

PROJECT_TITLE: A prospective examination of TAC features as predictors of consequences and alcohol use disorders

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: DOYLESTOWN

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: EVRYS BIO, LLC

ORG_STATE: PA

PHR: Chronic hepatitis B virus (HBV) infection can lead to cirrhosis of the liver, hepatocellular carcinoma or liver failure; current treatments control the disease but are rarely curative. The applicant has developed preliminary data suggesting that sirtuin-2 (SIRT2) inhibitors can potentially contribute to a cure for chronic HBV. The goal of this proposal is to advance these results to proof of principle in a mouse model of chronic HBV infection, followed by identification of a development candidate that can be advanced to IND status and clinical studies for treatment of chronic HBV infections.

PI_NAMEs: REMISZEWSKI, STACY  (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Animal Model;anti-hepatitis B;Anti-viral Agents;Biological Availability;candidate selection;Chronic Hepatitis B;Clinic;Clinical Research;clinical translation;computational chemistry;Cytomegalovirus;cytotoxicity;Data;design;Development;disorder control;DNA;DNA Viruses;Dose;Dose Limiting;Effectiveness;Enzymes;extracellular;Family;Genotype;Goals;HBV Genotype;Hepatitis B e Antigens;Hepatitis B Surface Antigens;Hepatitis B Therapy;Hepatitis B Virus;Hepatocyte;Human;improved;In Vitro;in vitro testing;in vivo;Inbred BALB C Mice;Individual;inhibitor;Liver;Liver Cirrhosis;Liver Failure;Measures;meter;Modeling;mouse model;Mus;Patients;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacotherapy;Phase;phase 2 study;Plasma;Primary carcinoma of the liver cells;programs;Proteins;prototype;Regimen;response;RNA Viruses;screening;Series;Serum;Sirtuins;small molecule therapeutics;Southern Blotting;Structure;success;Surface Antigens;Testing;Therapeutic;translation assay;Translations;Viral;Viral Physiology;Virion;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Development of a host-targeted antiviral as a chronic hepatitis B therapeutic with potential to achieve a functional cure


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Complementary and Integrative Health;Immunotherapy;Microbiome;Multiple Sclerosis;Neurodegenerative;Neurosciences;Nutrition;Precision Medicine

ORG_CITY: Rockville

ORG_NAME: RISE THERAPEUTICS, LLC

ORG_STATE: MD

PHR: Project Narrative Multiple Sclerosis (MS) is a devastating autoimmune disease driven by a derailed immune system that destroys myelin sheathing important for nerve conduction. This project aims to develop a novel immunological- directed L. lactis recombinant probiotic bacteria programmed to express and deliver colonization factor antigen I (CFA/I) to upregulate regulatory T cells leading to bystander tolerance. Successful commercialization would ultimately provide a profound front-line medical advancement for the treatment of MS.

PI_NAMEs: FANGER, GARY ;FURLAN FREGUIA, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Affect;Animals;Anti-Inflammatory Agents;Antigens;Autoimmune Diseases;autoimmune pathogenesis;Bacteria;Biological Markers;Biological Response Modifier Therapy;biomarker identification;Blindness;capsule;Cell Line;cell type;Cells;Clinical;Clinical Trials;colonization factor antigens;Colony-forming units;commensal microbes;commercialization;Communication;Consumption;cost;curative treatments;cytokine;Data;Dendritic Cells;design;Disease;disease phenotype;Dose;drug mechanism;drug quality;Drug toxicity;dysbiosis;effector T cell;Environment;Equilibrium;Experimental Autoimmune Encephalomyelitis;first-in-human;Food;gastrointestinal epithelium;Genetic;Goals;gut microbiome;gut-brain axis;Homeostasis;Human;Immune;Immune response;Immune system;Immunologics;improved;in vivo;in vivo evaluation;Incidence;Inflammatory;Infrastructure;Intestines;Kidney Failure;Lactococcus lactis;Life;Ligands;Local Therapy;manufacture;Materials Testing;Mediating;Medical;microbiome;Modeling;Mucous Membrane;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Mus;Myelin;Neural Conduction;novel;novel strategies;novel therapeutics;Oral;pathogen;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;Positioning Attribute;pre-Investigational New Drug meeting;Prevalence;prevent;Probiotics;Process;product development;Quality of life;Recombinants;Regulatory T-Lymphocyte;Reproducibility;research clinical testing;response;Risk;Role;Safety;safety assessment;Severity of illness;side effect;Social Interaction;Stroke;Symptoms;synthetic biology;System;targeted delivery;targeted treatment;Therapeutic;Toxicology;Up-Regulation;Validation;Well in self;Work

PROJECT_TITLE: A Novel Immunological-Directed Synthetic Biology-Based Drug for the Treatment of Multiple Sclerosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: NORTH CHICAGO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

ORG_STATE: IL

PHR: Project Narrative Impairments of social function and their underlying brain circuits are common to multiple psychiatric disorders. Adolescence is a sensitive period for social and neural development that often coincides with the emergence of psychiatric disorders. We need to learn more about the synaptic and molecular substrates that promote the function and maturation of social brain circuits to understand the pathophysiology of impaired social function.

PI_NAMEs: ROSENKRANZ, JEREMY E (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;AMPA Receptors;Amygdaloid structure;Anterior;Behavioral;behavioral pharmacology;Brain;Brain region;Cues;Data;Development;Electrophysiology (science);Elements;Equilibrium;experience;Fiber;flexibility;Functional disorder;Glutamates;Goals;Impairment;Interneurons;Learning;Measures;Medial;Mental disorders;Molecular;motivated behavior;Motivation;neural circuit;neurodevelopment;Neurons;novel strategies;Output;Parvalbumins;Permeability;Pharmacology;Photometry;Physiology;postsynaptic;Prefrontal Cortex;Primates;Proteins;recruit;Regulation;Research;response;Risk Factors;Rodent;Role;Satiation;Shapes;social;Social Adjustment;Social Behavior;Social Change;Social Conditions;social defeat;social deprivation;Social Development;Social Environment;Social Functioning;social influence;Social isolation;Social support;Stimulus;Stress;Suicide;Symptoms;Synapses;Testing;transition to adulthood;Work

PROJECT_TITLE: Parallel maturation of social behaviors and amygdala circuits

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Sleep Research

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Neuropsychiatric disorders are often associated with sleep and memory disruption. Sleep contributes to the stabilization of new memories for long periods of time, but we are far from understanding the single cell mechanisms by which sleep contributes to memory. This project will shed light on the cellular underpinnings of sleep-dependent memory consolidation, providing the necessary mechanistic understanding to develop novel effective treatments for neuropsychiatric illness.

PI_NAMEs: VARELA, CARMEN  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Area;behavior test;cell cortex;Cells;clinically relevant;Cognition;Cognitive;cognitive function;Complement;Computer Models;Coupling;Data;Detection;effective therapy;Electrophysiology (science);extracellular;Fire - disasters;flexibility;Frequencies;Goals;Hippocampus;Impaired cognition;Impairment;improved;Intervention;Knowledge;Learning;Measures;Medial;Memory;memory acquisition;memory consolidation;Modeling;Neocortex;neocortical;neural;Neurons;neuropsychiatric disorder;neuropsychiatry;non rapid eye movement;novel;optogenetics;Outcome;Pattern;Performance;Periodicity;Population;Post-Traumatic Stress Disorders;Prefrontal Cortex;Rattus;Reuniens Thalamic Nucleus;Role;Schizophrenia;Sleep;Sleep disturbances;success;synergism;System;Thalamic structure;Time;Training

PROJECT_TITLE: Thalamocortical Temporal Dynamics Underlying Memory Consolidation during NREM Sleep

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PI_NAMEs: CHAN, ANDREW T (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Address;adenoma;Adenomatous Polyps;Adolescence;Adolescent;Adult;Age;age related;aged;Alcohol consumption;Alcohols;Anatomy;Animal Model;anti-cancer research;Asia;Automobile Driving;binge drinking;Biological;Biological Factors;Biological Models;Birth;Body Weight Changes;cancer diagnosis;Cancer Etiology;cancer initiation;cancer prevention;Cells;Cesarean section;Cessation of life;Chemicals;Chemistry;chromatin modification;cohort;Cohort Effect;Collaborations;Collection;colon cancer risk;Colorectal Cancer;colorectal cancer risk;Colorectal Neoplasms;Computational Biology;Conceptions;Data;Dedications;design;Development;Diabetes Mellitus;Diagnostic;Diet;dietary;Dietary intake;Dimensions;Discipline;Disease;Disease Outcome;diverse data;drinking;Early identification;early life exposure;early onset;early onset colorectal adenoma;early onset colorectal cancer;Ecosystem;emerging adult;Environmental Epidemiology;Environmental Exposure;Environmental Risk Factor;Epidemiologic Factors;Epidemiology;epidemiology study;epigenome;Epithelial Cells;Ethnic Origin;Etiology;Europe;experimental study;Exposure to;follow-up;France;Frequencies;Future;Future Generations;Generations;genomic signature;Genomics;Geography;Goals;gut microbiome;Health;high risk;Homeostasis;Human;Human body;Immunology;imprint;improved;Incidence;indexing;Individual;innovation;Intake;Latin America;Lesion;Letters;Life Cycle Stages;life span;lifestyle intervention;Link;Location;Malignant Neoplasms;Measurement;Measures;Mediating;men;Metabolic;Metabolic syndrome;Mexican;Mexico;microbial;microbiome sequencing;Mind;Modeling;Molecular;Nature;novel;Nurses' Health Study;Obesity;obesogenic;offspring;offspring obesity;Pathway interactions;Pattern;pharmacologic;Physiological;pollutant;Population;population based;Positioning Attribute;Predisposition;Prevalence;prevent;Prevention;Prevention strategy;preventive intervention;Process;Prospective Studies;Race;Rectal Cancer;Reporting;Reproducibility;Reproducibility of Results;Research;Resolution;Resources;Risk;Risk Assessment;Risk Factors;risk stratification;Role;small molecule;social;social determinants;stem cell biology;sugar;Sulfur;Sulfur-Reducing Bacteria;Surveys;sweetened beverage;teacher;Techniques;Technology;Term Birth;Testing;Tissues;Translating;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;Unhealthy Diet;Validation;Variant;Vision;Vitamin D;Woman;Work;Workplace;young adult

PROJECT_TITLE: MGH- PROSPECT: Pathways, Risk factors, and mOleculeS to Prevent Early-onset Colorectal Tumors


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Public Health Relevance Statement The research outlined in this R01 application will investigate how FOSL1-Super-Enhancers (FOSL1-SEs) maintain the functional properties of cancer stem cells that lead to chemotherapy resistance in head and neck cancer. We also aim to verify such a mechanism by applying potential FOSL1 degraders targeting FOSL1-SEs to eliminate cancer stem cells effectively and overcome chemotherapy resistance in animal models. The ultimate goal of this study is to validate FOSL1-SEs as a promising drug target to significantly improve head and neck cancer chemotherapy outcomes.

PI_NAMEs: LI, JIONG  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: absorption;Address;analog;Animal Model;anti-cancer;Binding;Biological Assay;BMI1 gene;cancer stem cell;cancer therapy;Cell Line;Cells;Chemoresistance;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;ChIP-seq;Cisplatin;Clinical Treatment;cohort;Complex;computational chemistry;design;Development;Drug resistance;Drug Targeting;effective therapy;Enhancers;Excretory function;Family;Family member;FOSL1 gene;Genes;Genetic Transcription;Goals;Growth;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;HPV negative;HPV-negative head and neck cancer;improved;improved outcome;In Vitro;in vitro activity;in vivo;inhibitor;insight;interest;Investigation;jun Oncogene;Libraries;Ligands;Malignant - descriptor;Malignant Neoplasms;Mediating;member;Metabolism;mouse model;multicatalytic endopeptidase complex;Neoplasm Metastasis;novel;novel strategies;novel therapeutic intervention;Parents;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase II Clinical Trials;Play;Population;prevent;programs;Property;Protac;Proteins;public health relevance;Publications;Recurrence;Reporter Genes;Research;Resistance;Rheumatoid Arthritis;Role;screening;small molecule;Solid Neoplasm;stem cell biomarkers;stem cell population;stemness;Structure-Activity Relationship;Survival Rate;System;Testing;Therapeutic;therapy outcome;Toxic effect;Transcription Factor AP-1;transcriptome sequencing;Treatment outcome;tumor;tumor growth;tumorigenesis;Ubiquitin;ubiquitin-protein ligase;United States;Validation;Western Blotting

PROJECT_TITLE: FOSL1-super-enhancers define cisplatin-enriched cancer stem cells in HNSCC

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Genetics;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Peripheral Neuropathy;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Mu opioids such fentanyl and oxycodone are potent in relieving pain, but produce adverse side-effects such as tolerance, respiratory depression, reward and addiction, leading to the worldwide opioid epidemic and climbing opioid overdose death. The proposed studies aim to establish the mu opioid receptor exon 7-associated full- length variants as therapeutic targets using antisense oligonucleotide (ASO) and antibody, providing the groundwork for developing a therapeutic medication that combines clinically used mu opioids with an inhibitor (antibody or ASO) to mitigate the adverse effects of mu opioids in pain management.

PI_NAMEs: PAN, YING-XIAN  (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acids;addiction;Adverse effects;Alternative Splicing;Amino Acids;Antibodies;Antisense Oligonucleotides;Attenuated;beta-arrestin;Biotin;C-terminal;Cell Line;Cell model;Cell Nucleus;Cells;Central Nervous System;chronic constriction injury;chronic painful condition;Clinical;clinical effect;Combination Medication;Data;Development;Exons;experience;Experimental Designs;experimental study;Fentanyl;Foundations;Freund's Adjuvant;Genes;Goals;Homologous Gene;Human;Hyperalgesia;In Vitro;in vivo;inflammatory pain;inhibitor;Intravenous;Knockout Mice;Knowledge;Label;Length;locked nucleic acid;Macaca mulatta;Mainstreaming;Mediating;Modeling;Monkeys;Monoclonal Antibodies;morphine tolerance;mouse model;mRNA Precursor;mu opioid receptors;Mus;nanobodies;Neurons;new therapeutic target;opiate tolerance;Opioid;opioid abuse;Opioid Analgesics;opioid epidemic;opioid mortality;opioid use;opioid use disorder;Oryctolagus cuniculus;Oxycodone;Pain management;pain model;pain relief;painful neuropathy;Peripheral Nervous System;Permeability;Phenotype;preference;preservation;Protein Isoforms;Proteomics;receptor;Receptor Gene;Rewards;RNA Splicing;Rodent;Role;Scientist;Self Administration;Services;side effect;Tail;Therapeutic;therapeutic target;transcriptome sequencing;Variant;Ventilatory Depression

PROJECT_TITLE: Establishing Oprm1 exon 7-associated variants as novel therapeutic targets for mitigating adverse effects of clinically used mu opioids without altering analgesia in pain management

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Child Abuse and Neglect Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health;Violence Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Childhood neglect causes cognitive deficits that can be reversed with enrichment early in life across diverse mammalian species including humans and rodents. Here we hypothesize that neglect early in life impairs the removal of non-functional connections from circuits that control learning and that this process is reversed with enrichment. If confirmed, this work will help develop novel strategies to improve cognition in neglected children.

PI_NAMEs: KAFFMAN, ARIE  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: 3-Dimensional;Abbreviations;Adolescent;Animal Model;Beds;Behavioral;Birth;Brain;Child;Child Abuse and Neglect;child neglect;Cognition;Cognitive;Cognitive deficits;cognitive development;Collaborations;conditioned fear;Corpus Callosum;critical period;Data;density;deprivation;Development;Dorsal;early life adversity;Eating;Excision;Exposure to;Functional Magnetic Resonance Imaging;Future;Genetic;Glutamates;Hippocampus;Human;Hyperactivity;Impairment;improved;indexing;Knockout Mice;Label;Learning;Life;Mediating;Memory;Microglia;Modeling;Molecular;mouse model;Mus;neglect;Neurons;neurotransmission;novel;novel strategies;Outcome;overexpression;Phagocytes;physical abuse;postnatal;Poverty;prevent;Process;pup;receptor;Resources;Rest;Rodent;Rodent Model;Role;Sensory;Sexual abuse;Signal Transduction;Synapses;synaptic pruning;Testing;Thinness;TREM2 gene;Work

PROJECT_TITLE: Microglial TREM2 Mediates Hippocampal Synaptic and Cognitive Sequela of Early Deprivation and Enrichment

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: EUGENE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE With aging, there is increased stiffness of the large arteries (i.e., the aorta and carotid arteries) and stiffer large arteries are associated with Alzheimer’s disease and problems with memory. The proposed studies will determine, for the first time, the cause-and-effect relation between large artery stiffness and impairments in the brain. The knowledge gained from these studies will help identify new methods to prevent or treat Alzheimer’s disease.

PI_NAMEs: WALKER, ASHLEY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: abeta accumulation;Abeta synthesis;Advanced Glycosylation End Products;Affect;age related;Aging;aging brain;Alzheimer's Disease;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Aorta;Area;arterial stiffness;Arteries;arteriole;Attenuated;attenuation;Blood capillaries;Blood flow;Blood Pressure;Blood Vessels;blood-brain barrier permeabilization;Brain;candidate identification;Carotid Arteries;cerebral artery;cerebral microbleeds;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular reactivity;Cerebrovascular system;Clinical Research;Collecting Cell;Data;Dementia;Development;Disease;Elastin;Elderly;endothelial dysfunction;Functional disorder;Future;Gene Expression;Goals;Hemorrhage;human subject;Impaired cognition;Impairment;inhibitor;innovation;Intervention;Knowledge;Late Onset Alzheimer Disease;Lead;Learning;Link;Measures;Memory;Memory impairment;Methods;Modeling;mouse model;Mus;Mutation;Nerve Degeneration;neuroinflammation;Neurons;neuropathology;new therapeutic target;novel;old mice;Oxidative Stress;Pathology;pharmacologic;Phenotype;presenilin-1;pressure;Prevalence;prevent;Prevention;Pulse Pressure;Pyridoxamine;Research;Risk;Risk Factors;Role;Source;Testing;Therapeutic;Thinness;Time;Tissues;transcriptome;transcriptome sequencing;Transgenic Mice;Vascular Diseases;Vascular Endothelial Cell;Wild Type Mouse

PROJECT_TITLE: Large artery stiffness and cerebrovascular dysfunction: Implications for cognitive impairment and neuropathology

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Retinopathy of prematurity (ROP) vision loss results from aberrant vascular development within the incompletely vascularized preterm infant retina in response to postnatal oxygen stress, which cannot be safely modulated to prevent ROP. In-utero exposure to preeclampsia or chorioamnionitis is associated with postnatal vasoprotection and reduced ROP development; the underlying mechanisms are unclear. We have identified the Lim homeobox transcription factor 5 (LHX5) as a possible mediator of vasoprotection within both placental conditions; the proposed research builds on this to clarify mechanisms by which LHX5 may mediate vasoprotection, including its established role as a WNT antagonist, within the placental and ocular microenvironment.

PI_NAMEs: OWEN, LEAH A (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Animal Model;antagonist;Birth;Blindness;Blood Vessels;Cell Differentiation Induction;Childhood;ChIP-seq;Chorion;Circulation;Clinical;clinical care;clinical development;Data;design;Development;Disease;Disease Progression;disorder prevention;disorder risk;effective intervention;Exposure to;Eye Development;Fetoplacental Circulation;frizzled related protein-1;Gene Expression;Genetic Transcription;Genetic Variation;Goals;Health;Histologic;Histology;Homeobox;improved;In Vitro;Incidence;induced pluripotent stem cell;Infant;Interruption;intraamniotic infection;Lasers;loss of function;Low Birth Weight Infant;Measures;Mediating;Mediator;Methylation;Microdissection;Morbidity - disease rate;mRNA Expression;novel;Outcome;Oxygen;Oxygen Therapy Care;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Placenta;Placental Circulation;Plasma;postnatal;pre-clinical;Pre-Eclampsia;Pregnancy;Premature Infant;prenatal exposure;prevent;Prevention;preventive intervention;promoter;protein expression;Proteome;Regulation;Research;response;Retina;Retinopathy of Prematurity;Risk;Role;Small Interfering RNA;stem cell model;Stress;Structure of retinal pigment epithelium;Supplementation;Testing;Therapeutic;Therapeutic Effect;therapeutic target;tissue-factor-pathway inhibitor 2;Tissues;transcription factor;Transcriptional Activation;Transcriptional Regulation;transcriptome;Vascular Diseases;Vascularization;Villous;Vision;Visual;whole genome;WNT Signaling Pathway

PROJECT_TITLE: Mechanisms of Placentally-Mediated ROP Protection

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE The hippocampus and entorhinal cortices are key for the formation of episodic memories and spatial maps, but how the coordination of cell assemblies across these structures supports these processes is not yet understood. In this proposal, we will deploy a novel approach for recording across layers and regions and selectively manipulating neural coordination in this circuit, lifting current technical barriers. By revealing how temporally structured population activity develops during learning and is replayed during sleep we will provide novel insights into the mechanisms of episodic memory formation and consolidation, processes that go awry in a variety of neuropsychiatric disorders.

PI_NAMEs: FERNANDEZ-RUIZ, ANTONIO  (contact)

PROJECT_TITLE: Mechanisms and functions of temporal coordination in the entorhinal-hippocampal network


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: CHICAGO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative The annual cost to society of anxiety disorders, such as post-traumatic stress disorder (PTSD) is estimated to be over $42 billion, often due to inadequate treatment. PTSD is characterized by intrusive and debilitating fear responses during memory retrieval that are difficult to treat due to a lack of understanding of the neural mechanisms that underlie fear memory retrieval. The research proposed here will provide detailed mechanistic insight into how brain circuits regulate fear memory retrieval which could reveal novel targets for the treatment of PTSD.

PI_NAMEs: SHEFFIELD, MARK E J (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Address;Anatomy;Animals;Anxiety Disorders;anxious;Automobile Driving;Axon;Behavior;Behavioral;Brain;Brain region;Calcium;Cardiovascular Diseases;Cell Nucleus;Cells;Cessation of life;Chronic;Clinical;conditioned fear;cost;Data;Data Set;Dendrites;Dimensions;Discrimination;Disease;Distal;effective therapy;Emotional;Ethology;Event;Exhibits;experience;Extinction;Family;fear memory;Fire - disasters;Freezing;Fright;Genetic;genetic approach;genetic manipulation;Head;Hippocampus;Image;Impairment;Individual;Injury;innovation;insight;Investigation;Knowledge;Laboratories;Learning;Life;Link;Location;Machine Learning;Maps;Measurable;Measures;Medial;Memory;memory encoding;memory process;memory retrieval;Methods;Mus;neural;neuromechanism;neuronal cell body;Neurons;Nightmare;novel;novel strategies;Numbness;optogenetics;Pathway interactions;Patients;Personal Satisfaction;Persons;Phase;physical conditioning;Physiological;place fields;Play;Population;Population Dynamics;Post-Traumatic Stress Disorders;Prefrontal Cortex;prevent;Process;Publishing;Pyramidal Cells;Ramp;Research;Resistance;response;Retrieval;Reuniens Thalamic Nucleus;Role;Signal Induction;Signal Transduction;societal costs;Societies;Structure;Survivors;Synapses;Synaptic plasticity;Techniques;Testing;Thalamic structure;theories;tool;Trauma;traumatic event;treatment strategy;two photon microscopy;two-photon;vector;virtual;virtual reality;Work

PROJECT_TITLE: Investigation of a thalamic-hippocampal pathway in contextual fear suppression and extinction

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE There is an urgent need to advance from the discovery of genes that are strongly associated with autism spectrum disorders (ASDs) to the identification of basic biological mechanisms as a path to discover new therapeutic targets. We propose to use an innovative, high-throughput approach to investigate the function of multiple ASD genes in parallel in the developing brain. Our central goal is to identify novel pathways downstream of ASD genes and pharmacological targets for further investigation.

PI_NAMEs: HOFFMAN, ELLEN J (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: autism spectrum disorder;Behavioral;Behavioral Assay;behavioral pharmacology;behavioral phenotyping;Biological;Brain;Brain Mapping;Brain region;brain size;candidate identification;cell type;Databases;Drug Targeting;FDA approved;Functional disorder;Funding;gene discovery;Genes;Genetic;Goals;Human;human induced pluripotent stem cells;Image;in vivo;in vivo evaluation;in vivo imaging;innovation;Investigation;Label;loss of function;Molecular;molecular phenotype;Molecular Profiling;Molecular Target;mutant;neurogenesis;Neuroimmune;new therapeutic target;novel;Nuclear RNA;Outcome;Outcomes Research;Pathway interactions;pharmacologic;Phenotype;Process;Risk;risk variant;Role;Signal Transduction;Subgroup;System;Testing;transcriptome sequencing;transcriptomics;Translating;Zebrafish

PROJECT_TITLE: High-throughput Functional Analysis of Autism Risk Genes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (57)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE Alzheimer’s disease, the leading cause of dementia, is characterized by the buildup of abnormal proteins in the brain, but how these changes affect cells and lead to nerve cell damage is still unclear. Our goal is to investigate how Alzheimer’s-related pathology influences the expression of different forms of RNA, which play a crucial role in controlling gene activity. By using advanced sequencing technologies, we will uncover how specific genes are affected at the level of individual cells and their spatial distribution within the brain, ultimately shedding light on the progression of Alzheimer’s disease.

PI_NAMEs: GREGORY, SIMON G (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: abeta accumulation;Accounting;Address;Affect;Age;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-Protein;Automobile Driving;base;Brain;brain cell;Brain region;cell injury;Cell Nucleus;cell type;Cells;Complement;Complementary DNA;Custom;Data;Dementia;design;Development;Diagnosis;Disease;Disease Progression;Effector Cell;entorhinal cortex;Event;exome;exon skipping;Exons;experimental study;Functional disorder;Gene Expression;Genes;Genetic Transcription;Goals;Hematoxylin and Eosin Staining Method;Human;Immunofluorescence Immunologic;in situ sequencing;Individual;Inferior frontal gyrus;insight;Light;Literature;Location;Maps;Masks;Methods;Molecular;mRNA Decay;multiple omics;Nerve Degeneration;Nervous System Disorder;Neurofibrillary Tangles;Neurons;neuropathology;Nonsense-Mediated Decay;novel;novel strategies;Outcome Assessment;Pathogenesis;Pathology;Pathway interactions;Phase;Play;Prevention Research;Prevention strategy;programs;Protein Isoforms;Proteins;Protocols documentation;Race;Refractory;Research;Research Personnel;resilience;Resolution;response;Ribonucleases;RNA;RNA Splicing;Role;Sampling;Senile Plaques;sex;single nucleus RNA-sequencing;Site;Source;Spatial Distribution;spatiotemporal;Spliceosomes;Stains;Stress;Structure;Structure of middle temporal gyrus;targeted sequencing;tau Proteins;Techniques;Technology;Testing;therapeutic target;Tissues;transcriptome;transcriptome sequencing;transcriptomics;treatment research;treatment strategy;U1 Small Nuclear Ribonucleoprotein;Validation;Variant

PROJECT_TITLE: Characterizing Spatial Variations in RNA Isoform Expression with Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Prevention;Stroke

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative: Down syndrome (DS) is one of the most common genetic disorders with a prevalence of 1 per 700 liveborn infants in the United States and is associated with an increased risk of developing cerebrovascular disorders (CeVD), which commonly present with stroke as the first evidence of disease. The proposed research will result in the creation of a validated, non-invasive, low-cost, biometric screening tool for young persons with DS in order to address the pressing need of reliable screening of CeVD in at-risk individuals. This proposal presents a five-year research career development program with training that will position me with a unique set of interdisciplinary skills to enable transition to independence as a physician-scientist to study the prediction and prevention of CeVD in persons with DS.

PI_NAMEs: SANTORO, JONATHAN DOUGLAS (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Acceleration;Accounting;Active Learning;Address;Age;aged;Architecture;Area;Bioinformatics;Biological Markers;biomedical informatics;Biometry;Blood Pressure;blood pressure elevation;blood pressure reduction;Blood Vessels;Brain;career;career development;Caring;CCL2 gene;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Child;Childhood;Chronic;chronic inflammatory disease;Clinical Trials;Clinical Trials Design;cohort;Communication;comparison control;Competence;cost;Data;Data Analyses;Deposition;design;Development;Development Plans;Diagnosis;Disease;Disease Pathway;Down's Syndrome;Early Diagnosis;Early identification;Early Intervention;early screening;Edema;Educational workshop;Ensure;Epidemiology;Etiology;experience;feasibility research;Functional disorder;Funding;Genetic Diseases;Gliosis;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Head and neck structure;Health;Health Sciences;Healthcare;Height;Hemosiderin;Home;Hypertension;Hypotension;Image;Immune;improved;Incidence;Individual;Infant;Inflammation;Inflammatory;Institution;Interferon Type II;interleukin-22;Interleukin-6;Investigation;K-Series Research Career Programs;Knowledge;Learning;Link;Location;Los Angeles;Magnetic Resonance Imaging;Measurement;Measures;Mentors;Mentorship;Metabolic dysfunction;Modality;Morbidity - disease rate;mortality;Moyamoya Disease;Neck;Neurocognitive;neurocognitive test;neurodevelopment;neuroimaging;Neurologic;Neurologic Symptoms;Patients;Persons;PGF gene;Physicians;population based;Positioning Attribute;predictive marker;Prevalence;prevent;Prevention;Program Development;prospective;Prospective Studies;Publishing;Regression Analysis;Reproducibility;Research;Research Personnel;response;Retrospective Studies;Risk;Risk Assessment;Role;Scientist;screening;Screening procedure;Secondary to;sex;skills;Standardization;Stenosis;Stroke;systemic inflammatory response;Techniques;Therapeutic Intervention;Time;TNF gene;tool;Training;Transcranial Doppler Ultrasonography;Ultrasonography;United States;United States National Institutes of Health;Vascular Cell Adhesion Molecule-1;Vascular Diseases;Vascular Endothelial Growth Factors;vascular inflammation;Weight;Work

PROJECT_TITLE: Non-invasive biometric screening for cerebrovascular disorders in persons with Down syndrome.

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Diabetes;Genetics;Maternal Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Rare Diseases;Spina Bifida;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE Pregestational maternal diabetes induces neural tube defects, but the underlying epigenetic mechanism is still elusive. This project will determine the role of altered RNA metabolism by an microRNA, a RNA binding protein, and a long non-coding RNA, in maternal diabetes-disrupted cell fate decisions. The study will provide new mechanistic insights and therapeutic targets for diabetic embryopathy.

PI_NAMEs: SHEN, WEI-BIN ;YANG, PEIXIN  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Affect;Antibodies;Apoptosis;Attenuated;Binding;Biological Assay;Biotin;Blood Vessels;Cell Aging;Cell Physiology;cell type;Cells;Cellular Stress;Child;Congenital Abnormality;Diabetes Mellitus;diabetic embryopathy;Diagnostic;DNA;Embryo;Embryonic Induction;Epigenetic Process;epigenetic regulation;exosome;Functional disorder;Gene Expression;Genetic Recombination;genetic signature;Genetic Transcription;Human;Hyperglycemia;Immunoprecipitation;Impairment;Induction of Apoptosis;insight;Knockout Mice;Label;Link;LoxP-flanked allele;maternal diabetes;Mediating;Microarray Analysis;MicroRNAs;Modeling;Multivitamin;Nerve Block;Neural Tube Defects;Neuroepithelial Cells;neuroepithelium;neurogenesis;Neuronal Differentiation;non-diabetic;novel;overexpression;Preconception Care;Pregnancy in Diabetics;prevent;progenitor;Repression;RNA;RNA metabolism;RNA-Binding Proteins;Role;senescence;single-cell RNA sequencing;stem cell differentiation;Teratogenic effects;Teratogens;Testing;therapeutic target;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;Untranslated RNA;vector;Woman

PROJECT_TITLE: Dysregulated RNA metabolism in cell fate of maternal diabetes-induced neural tube defects


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE This project will investigate the impact of extreme heat events and wildfire exposures (independently and jointly) on patients with end-stage kidney disease (ESKD). The study population will include patients with ESKD receiving in-center hemodialysis treatment at approximately 2,500 dialysis clinics operated by FMCNA between 2000-2019 and 2022-2025, which will enable the study team to examine how risk is modified by patient-level sociodemographic variables, intra-dialytic hypotension, and climate region. The findings will inform management guidelines and lead to the development of early warning systems helping treatment facilities manage caseloads and enable person-centric treatment.

PI_NAMEs: SAPKOTA, AMIR  (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Climate change, forest fires, and patients with end-stage kidney disease: A national scale vulnerability assessment

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Public health relevance statement: Methods developed in this proposal can be applied to the preparation of bioactive compounds, which will facilitate our understanding for human diseases and the development of therapeutics.

PI_NAMEs: TANG, WEIPING  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acylation;Address;Alkylation;Binding;Biological;Biological Process;Carbohydrates;catalyst;Cell surface;cell type;chemical synthesis;Chemicals;Chimera organism;Development;Disease;extracellular;Extracellular Protein;Glycoconjugates;Glycoproteins;Glycosides;glycosylation;Goals;human disease;hydroxyl group;Hydroxyl Radical;improved;Instruction;Ligands;Lysosomes;Methods;novel;Play;Polysaccharides;Preparation;Process;programs;protein degradation;Proteins;public health relevance;receptor;receptor mediated endocytosis;Reporting;Research;Role;Series;Site;Sulfate;therapeutic development;Transition Elements

PROJECT_TITLE: Chemical Synthesis and Biological Application of Carbohydrates and Glycoconjugates


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LITTLE ROCK

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE This project is relevant to public health because it focuses on improving our knowledge of regulatory pathways vital to female fertility, which is important because declining estrogen leads to infertility and premature menopause with heightened risks of metabolic and cardiovascular disease. We will identify key molecular effectors that mediate estrogen regulation of gonadotropes to provide diagnostic and therapeutic tools that promote healthy aging. This research is thus relevant to the part of the NIH/NICHD mission that relates to fertility and infertility as well as the NIH/NIA missions that link aging and infertility to overall health.

PI_NAMEs: CHILDS, GWEN V;MACNICOL, ANGUS M (contact);MACNICOL, MELANIE C

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Ablation;Adult;Aging;analysis pipeline;Anterior Pituitary Gland;Binding;Bioinformatics;Cardiovascular Diseases;Cell Cycle Inhibition;Cell Differentiation process;Cell Line;Cell Lineage;Cells;chromatin remodeling;Combined Modality Therapy;Development;Diagnostic;Elements;Endocrine;Epigenetic Process;Estrogen decline;Estrogens;Estrous Cycle;female fertility;Fertility;Gender;Genes;Genetic Transcription;Germ-Line Mutation;Goals;Health;healthy aging;Hereditary Disease;Homeostasis;Hormonal;Hormonal Change;hormone deficiency;Hormones;Human;human disease;Hypothyroidism;improved;Infertility;Knowledge;Lactation;Link;Mediating;Mediator;Messenger RNA;Metabolic;Metabolic Diseases;Mission;Molecular;mRNA Translation;National Institute of Child Health and Human Development;novel;Organism;paracrine;Pathologic;Pathway interactions;Physiological;Pituitary Gland;Pituitary Hormones;Play;Population;Post-Transcriptional Regulation;posttranscriptional;Premature Menopause;Process;Proteins;proteogenomics;Public Health;recruit;Regulation;Regulatory Pathway;Repression;reproductive;Research;Resources;response;Risk;Role;sex;Signal Transduction;Single Nucleotide Polymorphism;Specific qualifier value;Specificity;stem cell differentiation;stem cell function;stem cell population;stem cell self renewal;stem cells;Stress;Testing;Therapeutic;Therapeutic Intervention;tissue regeneration;tissue repair;Tissues;tool;transdifferentiation;Translational Activation;Translational Repression;tumor progression;United States National Institutes of Health

PROJECT_TITLE: Molecular mechanisms of pituitary plasticity

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative. The control of behavior, at its most fundamental level, relies on the motivation to seek information about the future, so that we can make good predictions and adaptively adjust our expectations. Malfunctions in these processes are associated with psychiatric disorders and maladaptive behavioral states, such as anxiety, persistent risk-seeking, obsessive compulsive disorder, and drug-addiction. This project aims to discover how the brain controls information seeking, how it anticipates when new information will arrive and what it will tell us, and how it uses this information to help us make adaptive decisions about the future.

PI_NAMEs: MONOSOV, ILYA E. (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Adaptive Behaviors;Age;Algorithms;Anatomy;Animals;Anterior;Anxiety;Area;Attitude;autism spectrum disorder;Basal Ganglia;Behavior;Behavior Control;Behavioral;Biological;Brain;brain control;cingulate cortex;Clinical;clinically relevant;Cognition;Curiosities;Data;Decision Making;Disease;Drug Addiction;Electrophysiology (science);Emotions;Endowment;expectation;Future;Globus Pallidus;Grant;Habenula;Health;Human;Individual;information seeking behavior;insight;Intelligence;Lateral;Learning;Macaca;Measures;Medial;Mediating;Mental Depression;Mental disorders;Modeling;Modernization;Monkeys;Mood Disorders;Motivation;Neocortex;neural circuit;Neural Interconnection;neural network;Neurons;novel;Obsessive-Compulsive Disorder;Outcome;Output;Pathway interactions;Positioning Attribute;Prefrontal Cortex;Primates;Probability;Process;Publishing;Punishment;Research;Resolution;Rewards;Risk;Role;Signal Transduction;Source;System;Testing;Thalamic structure;transmission process;Uncertainty;Work

PROJECT_TITLE: Mechanisms of Information Seeking in the Primate Brain

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: Pulmonary arterial hypertension (PAH) is a life-threatening disease that affects predominantly females of childbearing age characterized by progressive small vessel loss and right heart failure. Most current therapies work by dilating blood vessels, but no treatments have been found that can restore angiogenesis and prevent loss of small vessels. The research project presented here aims at demonstrating that Wnt7a/ROR2 is a major orchestrator for cardiopulmonary angiogenesis and its loss contributes to small vessel loss and right heart failure in PAH.

PI_NAMEs: DE JESUS PEREZ, VINICIO A (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Adherens Junction;Affect;angiogenesis;Animal Model;Blood capillaries;Blood Vessels;Cardiopulmonary;Cardiovascular system;Cell Differentiation process;Cell Extracts;Cell model;cell motility;Cells;chromatin immunoprecipitation;Clinical;Complex;Cytoplasmic Tail;density;Disease;DNA;DNA Methylation;Echocardiography;Endothelial Cells;endothelial dysfunction;Endothelium;Epigenetic Process;epigenetic regulation;Equilibrium;exosome;Female of child bearing age;Fluorescence Resonance Energy Transfer;Focal Adhesions;gene-editing approach;Genetic;Genetic Transcription;Goals;Histone Acetylation;Histone Deacetylation;Human;Hypermethylation;Hypoxia;Hypoxia Inducible Factor;improved;Integrins;KDR gene;Knockout Mice;Life;Ligands;Lung;lung microvascular endothelial cells;lung pressure;Measures;Messenger RNA;Microfluidics;Modeling;Molecular;Morphogenesis;Mus;novel;Outcome;Output;Pathogenesis;Pathologic;Pathway interactions;Patients;Permeability;Phosphorylation;planar cell polarity;prevent;Process;Proteins;Proteomics;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary Hypertension;pyrosequencing;Rattus;Receptor Protein-Tyrosine Kinases;Recombinants;Recovery;Regulation;Repression;Research Project Grants;response;restoration;right ventricular failure;Right Ventricular Function;Role;sensor;Signal Transduction;Supplementation;Testing;Therapeutic;therapeutic evaluation;Tissues;Vascular Endothelial Growth Factors;Vascular Endothelium;Vascular remodeling;VEGFA gene;Ventricular;Work

PROJECT_TITLE: The Wnt7a/ROR2 axis in the pathogenesis of pulmonary arterial hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(05)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Goal-directed behavior is impaired across many neuropsychiatric diseases, although the underlying molecular mechanisms and neural processes are still poorly understood. Our prior work established that mice with mutations in the synaptic adhesion molecule, Neurexin1α, are an important genetic model to understand the molecular and neural circuit contributions to multiple behavioral processes supporting goal-directed behavior. This proposal uses genetic/viral techniques, rigorous behavioral analyses, in vivo and in vitro neural recordings, and temporally precise manipulations of neural activity to investigate how Neurexin1α mutations impact cholinergic and dopaminergic neuromodulatory systems, leading to goal-directed dysfunction.

PI_NAMEs: FUCCILLO, MARC V (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Acetylcholine;Acute;Address;Architecture;autism spectrum disorder;Basal Ganglia;Behavior;Behavioral;Brain;Cell Adhesion Molecules;cell type;Cells;Choice Behavior;cholinergic;Corpus striatum structure;Data;Disease;Dopamine;dopaminergic neuron;Electrophysiology (science);Exhibits;flexibility;Functional disorder;Future;Genetic;Genetic Models;genetic risk factor;Gilles de la Tourette syndrome;Goals;Homozygote;Human;impaired driving performance;Impairment;In Vitro;in vivo;in vivo imaging;Interneurons;Knockout Mice;Knowledge;Mediating;Midbrain structure;Molecular;Mus;mutant;Mutant Strains Mice;Mutation;neural;neural circuit;Neurobiology;Neuromodulator;neuronal excitability;Neuronal Plasticity;Neurons;neuropsychiatric disorder;neuroregulation;neurotransmitter release;novel;optogenetics;Outcome;Output;Pathway interactions;Pattern;Periodicity;Population;presynaptic;Presynaptic Terminals;Process;Psychological reinforcement;Quality of life;recruit;Regulation;response;Rewards;Scanning;Schizophrenia;sensor;Sensory;Shapes;Signal Transduction;Slice;Source;Structure;Synapses;synaptic function;System;Techniques;Testing;Thalamic structure;Uncertainty;Viral;Wild Type Mouse;Work

PROJECT_TITLE: Molecular and Circuit Mechanisms of Neurexin1-Mediated Goal-Directed Dysfunction

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: UCI ADRC Overall Project Narrative The U.S. is in the midst of a crisis on Alzheimer's disease (AD) and Orange County California is in the epicenter as there are more people with AD living here than in 26 other states. The University of California, Irvine Alzheimer's Disease Research Center (UCI ADRC) is strategically located to have a major positive impact as we identify, quantify, and validate factors that influence the risk of AD across the lifespan. The UCI ADRC brings energetic and innovative multi-dimensional and multi-disciplinary approaches toward solving this insidious disease, contributes to several national collaborative efforts, and provides key resources to the research community, including studying special populations impacted by the disease, such as underrepresented ethnic groups, adults with Down syndrome, and the oldest-old.

PI_NAMEs: LAFERLA, FRANK M (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Address;Adult;Advisory Committees;Age;Aged, 80 and over;aging population;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapy;Asian Americans;Autopsy;Basic Science;Biological Markers;biomarker development;Blood;Brain Diseases;Brain Pathology;brain tissue;California;cell bank;Clinical;Clinical Research;Clinical Sciences;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;cohort;Collaborations;Communities;Complex;Computer software;Consent;County;Data;Data Analyses;data management;Data Set;Dementia;Development;Diagnosis;diagnostic criteria;Dimensions;Disease;Disparity;Down's Syndrome;Education;education research;effective therapy;Ensure;Epidemic;Ethics;Ethnic Population;Etiology;Faculty;Genetic;Goals;Image;Impaired cognition;in vivo;Individual;induced pluripotent stem cell;Infrastructure;innovation;insight;interdisciplinary approach;interdisciplinary collaboration;International;Knowledge;Leadership;life span;meetings;mild cognitive impairment;Mission;Modernization;Molecular;multidisciplinary;Nature;neuroimaging;neuropathology;next generation;novel;novel diagnostics;Older Population;open source;Oranges;Outcome;Participant;participant retention;Pathogenesis;Pathologic;Pathway interactions;Patients;Persons;Play;Populations at Risk;Predisposition;prevent;prodromal Alzheimer's disease;Productivity;Protocols documentation;Recording of previous events;recruit;recruitment science;Registries;Research;Research Methodology;Research Personnel;resilience;Resources;Role;Scholarship;Science;Scientist;Societies;Special Population;Stains;stem cell biology;success;Technology;Training;Translational Research;Universities;Vision;Work

PROJECT_TITLE: The Alzheimer's Disease Research Center at the University of California, Irvine


ORG_CITY: DALLAS

ORG_DEPT: SURGERY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Narrative/Public Health Impact Errors occurring during surgery have a significant impact on patient outcomes, but it is hard to monitor and improve team performance in the operating room. The operating Black Box (ORBB) captures and analyzes data on intraoperative performance, providing a unique opportunity for improvement. This proposal seeks to develop strategies for effectively implementing such technology and creating high-fidelity simulation-based training to reduce errors and improve patient safety.

PI_NAMEs: BALENTINE, COURTNEY J;SANKARANARAYANAN, GANESH  (contact)

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Developing strategies for implementation and use of the Operating Room Black Box

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Depression;Mental Health;Neurosciences;Osteoarthritis;Pain Research;Social Determinants of Health

ORG_CITY: RALEIGH

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE While osteoarthritis (OA) and associated pain is a major and growing public health problem that results in decreased mobility and compromised activity, its profound and debilitating effects on emotions, cognition, and quality of life are poorly characterized and often overlooked in most animal models. Dogs, who develop naturally- occurring osteoarthritis and associated pain, have similar emotional and cognitive features to humans that can be readily measured, offering a transformative opportunity to model these domains in a clinically relevant manner. We will leverage our unique combined expertise to develop and validate a feasible test battery to assess the emotional and cognitive domains in dogs with OA pain thereby optimizing this naturally-occurring pain model and providing endpoints for development of novel and non-opioid therapeutics that better capture the multidimensionality of the human chronic pain experience.

PI_NAMEs: GRUEN, MARGARET ELIZABETH (contact);HARE, BRIAN ;LASCELLES, DUNCAN

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Activities of Daily Living;addiction liability;Address;Adult;Affect;Affective;Analgesics;Animal Model;Animals;Anxiety;arthritic pain;Arthritis;Attention;Behavioral;Benchmarking;Biological Assay;Biological Process;biopsychosocial;canine model;Canis familiaris;Chronic;chronic pain;chronic pain patient;Clinical;Clinical Research;clinically relevant;Cognition;Cognitive;cognitive function;cognitive task;Collaborations;companion animal;Coupled;Degenerative polyarthritis;design;Development;Dimensions;disease model;effective therapy;Emotional;emotional distress;Emotions;Ensure;experience;Family member;feasibility testing;Fright;Goals;Human;Impairment;improved;innovation;Instruction;Knowledge;Lead;Measurable;Measures;Mental Depression;Mobility decline;Modeling;Molecular;Morbidity - disease rate;Musculoskeletal Pain;non-drug;non-opioid analgesic;novel;novel therapeutics;opioid overuse;osteoarthritis pain;Outcome;Outcome Assessment;Pain;pain catastrophizing;Pain Measurement;pain model;Pathology;Performance;performance tests;Persistent pain;Population;pre-clinical;Prevalence;Protocols documentation;Public Health;Quality of life;Records;Research;Research Personnel;Resources;response;Risk Taking;Rodent;Rodent Model;Sensory;Short-Term Memory;Sleep;social;social relationships;Structure;success;sustained attention;Techniques;Testing;Therapeutic;Time;Translational Research;Translations;Validation;Withdrawal;Work

PROJECT_TITLE: Innovative modeling of the biopsychosocial model in animals: Validation of outcomes for assessing emotional and cognitive domains affected by naturally-occurring chronic pain in dogs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-L (95)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Obesity;Patient Safety;Rare Diseases

PHR: PROJECT NARRATIVE Laparoscopic vertical sleeve gastrectomy (VSG), the most popular bariatric surgery, causes new-onset gastroesophageal reflux disease (GERD) and worsens pre-existing GERD. This randomized clinical trial at two academic medical centers will compare the effects of a modified VSG vs conventional VSG on GERD.

PI_NAMEs: MITTAL, RAVINDER K.;NGUYEN, NINH T (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Abdomen;Academic Medical Centers;Acids;bariatric surgery;Barrett Esophagus;Body mass index;Body Weight decreased;Chronic;Clinical;Clinical Trials;comorbidity;Data;design;Disease;disorder risk;Distal;Eligibility Determination;Esophagus;Fiber;follow-up;Functional disorder;Fundoplication;Future;Gastrectomy;gastric fundus;Gastroesophageal reflux disease;Goals;Hiatal Hernia;improved;Inferior esophageal sphincter structure;innovation;Length;Malignant neoplasm of esophagus;Manometry;Measures;meetings;Mission;Modification;National Institute of Diabetes and Digestive and Kidney Diseases;obese patients;Obesity;Operative Surgical Procedures;Outcome;Patients;Pilot Projects;preservation;pressure;Quality of life;Randomized;randomized, clinical trials;Reflux;Resected;Resolution;response;Risk;SF-36;Single-Blind Study;Site;Specimen;Stomach;stomach cardia;Techniques;Testing;Time

PROJECT_TITLE: Mechanistic and clinical outcomes of a surgical innovation aimed at minimizing GERD associated with vertical sleeve gastrectomy (INNOVATE-VSG)


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE MCC’s mission is to reduce the impact of cancer to the catchment area and beyond by discovering, translating, and delivering high-impact innovations in interdisciplinary cancer prevention and care, and prepare the next generation of cancer researchers. The CCSG provides critical infrastructure to support the research necessary to achieve our mission.

PI_NAMEs: SIMEONE, DIANE M (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: anti-cancer research;base;biobank;biobehavior;Biological Sciences;Biometry;California;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Control Research;cancer education;cancer health disparity;cancer prevention;Caring;Catchment Area;Clinic;clinical care;Clinical Data;Clinical Protocols;Clinical Trials;Communities;Community Outreach;Comprehensive Cancer Center;Computational Biology;cost;County;data management;Diagnostic;Engineering;Flow Cytometry;Fostering;functional genomics;Funding;Genomics;Goals;Growth;Health Sciences;Health system;Hematologic Neoplasms;Hospitals;Infrastructure;innovation;Lateral;Leadership;Malignant Neoplasms;Medicine;member;Microscopy;Mission;Monitor;multidisciplinary;next generation;outreach program;Peer Review;Peer Review Grants;Pharmacologic Substance;Pharmacy facility;physical science;Preventive;programs;Protocols documentation;Research;Research Personnel;Research Support;Research Training;Resource Sharing;Schools;Science;Signal Transduction;Solid Neoplasm;structural genomics;Technology;Testing;Therapeutic;Tissues;Training and Education;Transgenic Mice;Translating;Underrepresented Minority;Universities;University resources;Vulnerable Populations

PROJECT_TITLE: Specialized Cancer Center Support Grant


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Glaucoma is a leading cause of blindness worldwide. Despite the widely appreciated disease relevance of neuroinflammation and mitochondrial dysfunction as critical pathogenic elements, therapies targeting these processes are currently unavailable. The proposed immunogenicity assessment study supports the development of a novel AAV-AIBP gene therapy to reduce retinal neuroinflammation and provide effective neuroprotection to glaucoma patients.

PI_NAMEs: JU, WONKYU  (contact)

PROGRAM_OFFICER_NAME: CONRAD, CHRISTOPHER GARNER

PROJECT_TERMS: Apolipoprotein A-I;ATP binding cassette transporter 1;ATP-Binding Cassette Transporters;Automobile Driving;Award;Binding Proteins;Biological;Biological Assay;Blindness;C-terminal;CD8B1 gene;Cell Death;Cell model;Cells;Cholesterol;Cholesterol Homeostasis;cholesterol transporters;clinical risk;clinically relevant;Contract Services;Data;Dependovirus;Development;Disease;Disease Progression;Donor Selection;Dose;Elements;flexibility;Funding;gene therapy;Genes;Genetic Polymorphism;Glaucoma;glial activation;Goals;Grant;Human;Hydrostatic Pressure;immunogenicity;Individual;Inflammatory;inflammatory marker;Inflammatory Response;Interleukin-1 beta;Lead;lead candidate;Link;Membrane Microdomains;Microglia;Microspheres;Mitochondria;mitochondrial dysfunction;Modeling;Monitor;mouse model;Muller's cell;Mus;Nerve Crush;Nerve Degeneration;Neuroglia;neuroinflammation;neuroprotection;novel;Ocular Hypertension;Optic Nerve;Pathogenesis;Pathogenicity;Patients;Phase;Physiologic Intraocular Pressure;Population;preclinical study;Primary Open Angle Glaucoma;Process;Proliferating;protein expression;Proteins;receptor;Recombinant Proteins;Recombinants;Relative Risks;response;restoration;Retina;Retinal Ganglion Cells;Risk;Risk Assessment;Risk Factors;Sampling;Schedule;screening;Side;standard of care;T-Cell Activation;targeted treatment;Testing;Thymidine;Time;TLR4 gene;uptake;Visual Acuity;visual dysfunction;Work

PROJECT_TITLE: Development of AAV-AIBP for neuroprotection in glaucoma


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Regenerative Medicine;Women's Health Research;Wound Healing and Care

ORG_DEPT: DERMATOLOGY

PHR: RESEARCH NARRATIVE Many skin wounds do not heal properly. This grant will study the genetics of an unusual woman who has an enhanced ability to heal from skin injuries with a minimum of scarring. By understanding how her body is able to repair the skin so well, we hope to learn new therapeutic targets that could lead to new therapies for wound healing.

PI_NAMEs: SUN, BRYAN  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acceleration;Acute;aging population;Aldehydes;Alleles;Binding;Biological Assay;Biological Process;Cells;Chromatin;chronic wound;Cicatrix;Clinical;Dermatology;DNA;Enhancers;experience;experimental study;Fatty Acids;Fibroblasts;Foundations;gain of function;Genes;Genetic;Genetic study;Genetic Transcription;Genome engineering;genome sequencing;genomic locus;Genotype;Goals;Grant;Human;Hydrolase;improved;In Situ Hybridization;Individual;Injury;innovation;insight;keratinocyte;Knockout Mice;Laboratories;Learning;Link;Lipids;loss of function;Medical;Messenger RNA;MicroRNAs;migration;Modeling;Molecular;Molecular Conformation;Mutagenesis;Names;new therapeutic target;novel;novel therapeutics;older women;Organoids;Outcome;Pathway interactions;Patients;Phenotype;Physicians;Process;Property;Proteins;re-epithelialization;Regulatory Element;repair model;Research;Research Personnel;restraint;Role;Skin;skin healing;Skin injury;Skin repair;Skin Tissue;skin wound;Skin wound healing;skin xenograft;Study Subject;targeted treatment;Testing;tissue repair;Tissues;transcriptomics;United States;Untranslated RNA;Woman;wound;wound healing;Wound healing therapy;wound treatment

PROJECT_TITLE: Role of the FAAH-OUT locus in cutaneous wound healing

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Biotechnology;Brain Disorders;Depression;Drug Abuse (NIDA only);Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE  Tobacco Use Disorder is a major global public health problem, and understanding the neural mechanisms underlying its persistence holds promise to advance development of brain-based smoking-cessation therapies. Animal studies have indicated that the habenula is a critical brain structure for maintaining nicotine addiction, but rigorous human studies have not been conducted due to previous limitations in methodology and size of available data sets. Using a novel analysis approach and a very large neuroimaging and genetics data set, we will examine the relationship between functional connectivity of the habenula with cigarette smoking and genetic associations, providing support for novel smoking cessation therapies and extending knowledge of habenula function, which has clinical relevance beyond cigarette smoking.

PI_NAMEs: GHAHREMANI, DARA ;LONDON, EDYTHE DANICK (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Advanced Development;Amygdaloid structure;Animal Experimentation;Animal Model;Animals;Anxiety;Anxiety Disorders;anxiety symptoms;Applied Genetics;Aversive Stimulus;Behavioral;biobank;Brain;brain based;Brain imaging;Brain scan;Cell Nucleus;cigarette craving;cigarette smoking;clinically relevant;cohort;Data;data repository;Data Set;Deep Brain Stimulation;depression model;depressive symptoms;deprivation;Development;Disease;Disease remission;Efferent Pathways;Emotional;Emotions;Epithalamic structure;Exposure to;Functional Magnetic Resonance Imaging;General Population;Genetic;genetic architecture;genetic association;Genetic Determinism;Genetic Variation;genome wide association study;genomic data;genomic locus;genomic variation;Genomics;global health;Habenula;Heritability;Human;indexing;Knowledge;Link;Linkage Disequilibrium;Major Depressive Disorder;Measurement;Measures;Mediating;Mendelian randomization;Mental Depression;Mental disorders;Methodology;Methods;Midbrain structure;middle age;Mood Disorders;Motivation;Mus;negative affect;negative emotional state;Negative Reinforcements;neural;neural circuit;neuroimaging;neuromechanism;Neurons;Nicotine;Nicotine Dependence;nicotine self-administration;Nicotinic Receptors;nonhuman primate;novel;older adult;Participant;Pathway interactions;Patient Self-Report;Patients;Persons;phenome;Phenotype;polygenic risk score;precision medicine;Prefrontal Cortex;Prosencephalon;Protocols documentation;Public Health;Publishing;Quality Control;Research;Resolution;Rest;Rewards;Rodent;Role;Sample Size;Sampling;Scanning;secondary analysis;self-reported depression;Smoke;Smoking;Smoking Behavior;smoking cessation;smoking exposure;Smoking History;Source;statistics;Structure;substance misuse;success;System;Testing;therapeutic target;Tissues;Tobacco Use Disorder;Twin Studies;Variant;Ventral Tegmental Area;Withdrawal;Woman

PROJECT_TITLE: Habenula Circuitry, Smoking, and Genomics


FUNDING_MECHANISM: SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Cancer;Clinical Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care

ORG_CITY: BOCA RATON

ORG_NAME: SOAP, INC.

PI_NAMEs: CHARLAP, STEVEN  (contact)

PROJECT_TERMS: acceptability and feasibility;Adoption;Assessment tool;cancer care;cancer prevention;cancer risk;Cause of Death;Clinical;commercialization;Computer software;cost;Data;diagnostic accuracy;electronic health record system;Feedback;health goals;Health Planning;Image;improved;Incentives;Individual;Intake;interoperability;Interviewer;Knowledge;Legal patent;Malignant Neoplasms;Medical;Patients;Phase;Physicians;Population;Prevention;Primary Care;primary care patient;Primary Care Physician;primary care setting;Productivity;Risk;Screening for cancer;Societies;Testing;tool;United States;usability;Visit;Voice

PROJECT_TITLE: TOPIC 453: THE PERFECT MEDICAL ASSISTANT FOR CANCER PREVENTION WITHIN PRIMARY CARE


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Complex interactions among neurons, glia, immune and endothelial cells in the microenvironment drive the progression, treatment resistance, and recurrence of glioblastoma (GBM), an incurable primary brain tumor. The short-term goal of this project is to elucidate how a poorly understood microenvironmental interaction—namely, mitochondrial transfer from neural cells to GBM—drives tumorigenicity, focusing on astrocytes as predominant organelle donors. The long-term goal and future studies will (a) investigate the differential mechanistic role of mitochondrial transfer from diverse brain cell lineages, (b) interrogate how mitochondrial transfer influences spatio-temporal heterogeneity in primary and recurrent patient GBM specimens, and (c) develop therapeutics targeting molecular mediators of this protumorigenic interaction.

PI_NAMEs: WATSON, DIONYSIOS C (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Acetylation;Address;Affect;Astrocytes;ATAC-seq;Automobile Driving;Biological Assay;Biology;Bone Marrow;Brain;brain cell;Brain Neoplasms;cancer cell;career;career development;cdc Genes;Cell Cycle;Cell Lineage;Cell model;Cell Proliferation;Cells;chemotherapy;Chemotherapy and/or radiation;Chromatin;Coculture Techniques;Complex;Cytoskeleton;Data;design;Development;Disease;Endogenous Retroviruses;Endothelial Cells;Endothelium;Enzymes;Epigenetic Process;Fellowship;fluorophore;Frequencies;Future;Gap Junctions;Gene Expression;Gene Expression Profile;genetic manipulation;Genus Hippocampus;Glioblastoma;Glioma;Goals;Heterogeneity;Histone Acetylation;Human;Hypoxia;Immune;Immunodeficient Mouse;Immunotherapy;In Vitro;in vivo;inhibitor;insight;knock-down;Knowledge;Leukocytes;Link;Macrophage;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Mediator;Mentorship;Metabolic;Metabolism;metabolomics;Microglia;Mitochondria;Mitochondrial DNA;Mitochondrial Proton-Translocating ATPases;mitochondrial therapeutics;Mitosis;Modality;Modeling;Molecular;molecular targeted therapies;Morphology;mouse model;Mus;neoplastic cell;neural;Neuroglia;Neurons;Non-Malignant;Operative Surgical Procedures;Organelles;overexpression;Pathway interactions;patient derived xenograft model;Patients;Phase;Phenotype;Physicians;Primary Brain Neoplasms;Process;progenitor;programs;Proliferating;Proteins;purine/pyrimidine metabolism;Radiation therapy;receptor;Recurrence;Reporter;Research;Resistance;Role;Scientist;self-renewal;Shapes;single-cell RNA sequencing;Sorting;spatiotemporal;Specimen;standard care;stem;stem cells;Stress;Supporting Cell;syncytin;Testing;Therapeutic;therapeutic development;therapeutic target;therapy resistant;Training;transcriptome sequencing;Transgenic Mice;tumor;tumor growth;tumor metabolism;tumor microenvironment;Tumorigenicity

PROJECT_TITLE: Mitochondrial transfer from astrocytes to glioblastoma cells drives tumor growth


FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PHR: This agreement is for the operation of a computerized HIV database and analysis unit that provides an international research resource to aid in the development of vaccines and therapies and in the understanding of the pathology, genetics, and evolution of HIV.

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Agreement;Communities;Computer software;computerized;Data;Data Analyses;data dissemination;Databases;design;Epitopes;Equipment;Evolution;Genetic;HIV;HIV envelope protein;HIV-1;HIV-2;Immunologics;Immunology;interest;International;Lentivirus;Monoclonal Antibodies;operation;Pathology;Proteins;Research;Research Personnel;Resources;tool;Update;vaccine development

PROJECT_TITLE: HIV Database and Analysis Unit


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: Berkeley

ORG_NAME: NEUROBEHAVIORAL SYSTEMS, INC.

PHR: Project Narrative  Alzheimer’s disease and related disorders (ADRDs) is a health care burden with enormous medical and personal cost that will affect an increasing number of Americans as the population ages. ADRDs disproportionately affect ethnoracial minorities who are expected to constitute half of all ADRD cases in the US by 2060. Unfortunately, the cognitive tests needed to identify at-risk patients are not available in most minority communities who have also been largely excluded from clinical trials evaluating new therapies to slow ADRD disease progression. Here we propose to gather normative data from minority cohorts of English-speaking African Americans and Hispanics, and Spanish-speaking Hispanics using a set of innovative, sensitive computerized cognitive tests that can be telemedically administered in patients’ homes. These studies will facilitate the inclusion of minority populations in clinical trials and, in the future, improve minority access to cognitive testing at substantially reduced costs.

PI_NAMEs: PEBLER, PETER ;WOODS, DAVID L (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Address;Adult;Affect;African American;African American population;Age;Age-associated memory impairment;aging related;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Artificial Intelligence enhanced;automated speech recognition;Benchmarking;Black American;Black race;California;Cellular Phone;clinical development;Clinical Trials;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive testing;cohort;comparison group;computerized;Consensus;cost;Country;COVID-19;Data;Data Set;Dementia;design;Diagnosis;Diagnostic;Diagnostic and Statistical Manual of Mental Disorders;digital;digital assessment;Dimensions;Disease Progression;Disparity;Domiciles;Education;Enrollment;Ensure;Equation;Ethnic Origin;ethnoracial;ethnoracial disparity;ethnoracial minority;Exclusion;Factor Analysis;Future;Gender;Genetic Transcription;health disparity;healthcare burden;Hispanic;Hispanic Americans;hispanic community;Hispanic Populations;Home;Impaired cognition;improved;indexing;Individual;innovation;International;Interruption;Language;Language Tests;Learning;Manuals;Materials Testing;Measures;Medical;Methodology;Minority;Minority Access;minority communities;Minority Groups;Modernization;National Institute on Aging;neglect;Neighborhoods;Neuropsychology;Not Hispanic or Latino;novel therapeutics;older adult;Older Population;Participant;Patients;Pattern;peer;Performance;performance tests;Phase;Population;Population Heterogeneity;Psychometrics;Quality of Care;Questionnaires;recruit;Research;research study;response;Risk;Rural;Rural Community;rural dwellers;Sampling;sex;Small Business Innovation Research Grant;South Texas;Spanish;Speech;Statistical Methods;Statutes and Laws;suburb;symposium;Technology;Testing;testing access;Text;theories;Training;Translations;Transportation;underserved community;Underserved Population;United States;verbal;Voice

PROJECT_TITLE: At-home computerized assessment of normal cognitive aging and age-related cognitive decline in older African Americans, Hispanics, and rural non-Hispanic whites


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Arthritis;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Neurosciences;Osteoarthritis;Pain Research

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Reliable and well validated behavioral tests of pain are needed to evaluate and translate future pain-relieving therapies from the discovery phase to the clinic. This proposal seeks to evaluate the reliability and validity of pain-related behavioral metrics in the horse, which is an ideal veterinary population for the study of OA pain.

PI_NAMEs: ALLEN, KYLE D (contact);BIEDRZYCKI, ADAM H;BROOKS, SAMANTHA A;CRUZ-ALMEIDA, YENISEL

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: addiction liability;Adult;Agreement;Animal Model;Animals;articular cartilage;Behavior;Behavior assessment;behavior measurement;behavior test;Behavioral;Behavioral Assay;bench to bedside;Biological Assay;bone;Calibration;Cartilage;Characteristics;Clinic;Clinical;clinical heterogeneity;Collection;Data;Degenerative polyarthritis;design;Development;Disease;disease model;Disease Progression;drug discovery;Ecological momentary assessment;Enrollment;Equus caballus;Etiology;Evaluation;experience;Female;follow-up;Future;gait examination;Goals;heart rate monitor;Heterogeneity;Human;human data;Individual;Intervention;joint destruction;Joints;Knee Osteoarthritis;Laboratories;Ligaments;Locomotion;male;Measures;Meniscus structure of joint;Metacarpophalangeal joint structure;Metatarsophalangeal joint structure;Modeling;non-opioid analgesic;novel therapeutics;osteoarthritis pain;Pain;Pain Disorder;Pain management;Pain Measurement;pain relief;pain symptom;Pathology;patient population;Patients;Pattern;Persons;Pharmaceutical Preparations;Phase;Phenotype;Population;Prevalence;Privatization;programs;Protocols documentation;Psychometrics;radiological imaging;recruit;Reporting;response;Sensory;Severities;somatosensory;Symptoms;Synovial Membrane;Technology;Testing;therapy development;Time;Training;Translating;translational pipeline;Translations;United States;Validation;Validity and Reliability;wearable device

PROJECT_TITLE: Psychometric Reliability and Validity for Behavioral Metrics of Osteoarthritic Pain in Horses


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative Parents, pediatricians, and clinicians are concerned when children begin to talk late, a condition that affects 15% to 20% of children. Yet, little is known about bilingual late-talkers, their ability to learn information in both languages, and persistence vs. resolution of their language delay. This project examines how Spanish-English bilingual toddlers with typical language, bilingual late-talker, and bilingual children with Developmental Language Disorder (DLD) learn novel words in English and Spanish and what conditions can best facilitate their learning, with a particular interest in identifying risk and protective factors in bilingual late-talkers’ language outcomes.

PI_NAMEs: KAUSHANSKAYA, MARGARITA  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 2 year old;4 year old;Affect;Age;bilingualism;Child;Child Language;Cues;Development;Education;experimental study;Exposure to;Goals;Hour;improved;Individual;insight;interest;Intervention;Knowledge;Language;Language Delays;Language Development Disorders;language impairment;language outcome;Learning;Learning Disorders;Link;Literature;Maps;novel;Outcome;Parents;Participant;Pattern;pediatrician;peer;Predictive Factor;protective factors;Recording of previous events;Recovery;recruit;Resolution;Risk;Risk Factors;Role;Sampling;Series;Shapes;skills;Spanish;Spanish/English;spelling;statistical learning;stem;Structure;Suggestion;Testing;theories;Time;Toddler;United States;Vocabulary;word learning;Work

PROJECT_TITLE: Talking Late in Two Languages

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health

ORG_CITY: ITHACA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CORNELL UNIVERSITY

PHR: Income instability is a defining aspect of the lives of the poor, who also disproportionately suffer from poor mental and physical health. Our research is the first to assess the causal effects of predictable and unpredictable income instability on the psychological and physical health of the poor. It will advance the scientific knowledge on the effects of economic instability as well as our understanding of health disparities.

PI_NAMEs: SCHOFIELD, HEATHER  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Acceleration;Address;Affect;Age;age related;Aging;allostatic load;Anxiety;arm;Bangladesh;Behavioral;biological adaptation to stress;Biological Markers;Blood Pressure;cardiovascular disorder risk;Cell Aging;Contracts;Control Groups;coping;cost;Country;Data;Dementia;design;Disparity;Economics;Ensure;Ethics;Expenditure;experience;Experimental Designs;experimental study;Family;Food;Future;Gender;Goals;Health;health disparity;Hour;Hydrocortisone;Impaired cognition;Income;Individual;Institutional Review Boards;Intervention;Knowledge;Life;Low income;low income country;Mental Depression;Mental Health;Metabolic Diseases;Occupations;Outcome;Participant;Pattern;Personal Satisfaction;Persons;physical conditioning;Physiological;Policies;policy implication;Poverty;programs;psychologic;Randomized, Controlled Trials;rate of aging;Research;Research Personnel;Risk;Schedule;Scientific Advances and Accomplishments;Seasons;Stress;Surveys;Thinness;Time;treatment arm;Uncertainty;Visit;welfare;Work;World Bank

PROJECT_TITLE: Unstable Income, Rising Stress? The Effects of Income Instability on Psychological and Physiological Health

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ORG_CITY: ANN ARBOR

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Adolescence is a vulnerable time period when insufficient and mistimed sleep may affect cardiometabolic risk factors including adiposity, high blood pressure, and insulin resistance. To understand which aspects of sleep to intervene on, there is an urgent need to disentangle the independent contributions of short sleep duration and delayed sleep timing (proxy for circadian rhythm misalignment) to cardiometabolic risk. Examining the epigenetic pathways that link sleep duration and timing with prospective cardiometabolic risk provides a novel way to distinguish these relationships and to gain mechanistic insights.

PI_NAMEs: JANSEN, ERICA CHRISTINE (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: Achievement;actigraphy;Adolescence;Adolescent;Affect;ARNTL gene;Award;Behavioral;Biological;Biological Markers;Blood Pressure;Candidate Disease Gene;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;career;Characteristics;Chronic;circadian;circadian biology;Circadian desynchrony;Circadian gene expression;Circadian Rhythms;Cities;Clinical;cohort;Cohort Studies;Complex;Coupled;CpG dinucleotide;Cross-Sectional Studies;Data;design;Development;DNA Methylation;DNA Sequence;Environment;Epidemiologist;epidemiology study;epigenetic marker;Epigenetic Process;epigenome;experience;flexibility;follow-up;Funding;Future;Gene Expression;Genes;Goals;Grant;Health;Heritability;High Prevalence;Hypertension;improved;Inadequate Sleep Hygiene;insight;Insulin Resistance;Intervention;Investigation;Knowledge;Laboratories;Lead;Leadership;Leukocytes;life span;Link;Lipids;Measurement;Measures;media use;Mentors;Mentorship;Metabolic;Metabolic Diseases;methyl group;Methylation;Mexico;Michigan;Modification;Molecular;novel;nutrition;Nutritional;Obesity;Observational Study;Outcome;Participant;Pathway interactions;Play;Population;professor;prospective;Proxy;Puberty;puberty transition;Public Health;Public Health Schools;Research;Research Assistant;Research Design;Research Infrastructure;Resources;Risk;Risk Factors;Role;RORA gene;Schedule;Schools;skills;Sleep;Sleep Deprivation;Sleep disturbances;sleep pattern;Statistical Data Interpretation;Testing;therapy design;Time;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: Sleep and Circadian Rhythms in Adolescence: Epigenetic Pathways of Cardiometabolic Risk

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Prevention;Substance Misuse

ORG_CITY: LOS ANGELES

PI_NAMEs: ZACK, JEROME A. (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TITLE: Core A -Administrative Core


PI_NAMEs: YANG, OTTO O (contact)

PROJECT_TITLE: Core B -Developmental Core


PI_NAMEs: ALDROVANDI, GRACE M (contact)

PROJECT_TITLE: Core C -Centralized Laboratory Support Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Immunization;Prevention;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: KITCHEN, SCOTT G (contact)

PROJECT_TITLE: Core D -Humanized Mouse and Gene Therapy Core


PI_NAMEs: DEL PINO, HOMERO ERWIN (contact)

PROJECT_TITLE: Core E -Community Engagement and Clinical Informatics Core


PI_NAMEs: CHEW, KARA W (contact)

PROJECT_TITLE: Core F -Clinical Science Core


PI_NAMEs: GORBACH, PAMINA MAE (contact)

PROJECT_TITLE: SWG 1 -Translational Research on Substance Use SWG


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BOSTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE Psychostimulant use disorders, including cocaine addiction, are a major public health concern and lack FDA- approved treatments. Despite having a known genetic component, the genetic basis of cocaine addiction is largely unknown. This proposal seeks to use a discovery-based rodent genetic approach combined with multi- omics analysis to rapidly identify candidate causal genes, variants, and neuroadaptive mechanisms underlying risk traits and cocaine use traits in a highly simplified and tractable rat genetic cross.

PI_NAMEs: BRYANT, CAMRON D (contact);KANTAK, KATHLEEN M.

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: addiction;Behavior;Behavioral;behavioral phenotyping;biomarker panel;Brain;Brain region;brain tissue;Candidate Disease Gene;candidate identification;causal variant;Chromosome Mapping;Cocaine;Cocaine Dependence;cocaine seeking;cocaine self-administration;cocaine use;Complex;Data Set;design;differential expression;DNA;drug action;Exons;FDA approved;Female;forward genetics;functional genomics;Future;Genes;Genetic;genetic approach;Genetic Crosses;genetic variant;Genome Mappings;genome sequencing;genome wide association study;Genotype;Heritability;Impulsivity;Inbred SHR Rats;Inbred Strain;Inbreeding;Induced Mutation;insertion/deletion mutation;insight;Intake;Lead;male;Maps;Messenger RNA;Methamphetamine;Modeling;Molecular;Motor Activity;multiple omics;Mus;mutation correction;Neurobiology;Neuronal Plasticity;novel;Nucleus Accumbens;Pathway Analysis;Pharmaceutical Preparations;Phenotype;Prefrontal Cortex;Proteins;Proteomics;Public Health;Quantitative Trait Loci;Rattus;Research Personnel;Rewards;Risk;Risk Factors;Rodent;Saline;Signal Transduction;stimulant use disorder;Sucrose;System;Therapeutic;Training;trait;Transcript;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;translation to humans;translational potential;Translations;Validation;Variant;whole genome

PROJECT_TITLE: Systems genetics of premorbid and cocaine use traits in a rat reduced complexity cross


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: STONY BROOK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE: This proposal investigates a novel idea to explain some aspects of both the initiation of neurodegeneration and dementia diseases, and the spread of disease pathology, in the central nervous system. Based on prior evidence from our lab, our collaborators, and other researchers, we have evidence that elements within our own genomes, namely retrotransposons and endogenous retroviruses, become activated during aging and during initiation of neurodegenerative disease, both through known and unknown causes. This proposal will test the ideas that protein pathologies, specifically in the protein TDP-43, can have a causative role in releasing activity in previously suppressed retroviruses, which can then lead to disease mechanisms within affected cells, and to spread of disease between cells in the brain.

PI_NAMEs: SHER, ROGER B (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Affect;Aging;ALS pathology;Alzheimer's disease model;Alzheimer's disease related dementia;Biology;Brain;Cell Death;cell type;Cells;Central Nervous System;Dementia;Dependovirus;Development;Disease;Disease Progression;DNA Damage;doctoral student;Drosophila genus;Elements;Endogenous Retroviruses;experimental study;frontotemporal lobar dementia amyotrophic lateral sclerosis;gene function;genetic manipulation;Genome;Goals;graduate student;human tissue;in vivo;insight;Laboratories;Measures;Modeling;Mouse Strains;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;Neuroglia;Neurons;novel;parent grant;Pathology;Play;Population;protein TDP-43;Proteins;Research Personnel;Retrotransposon;Retroviridae;Rodent;Role;System;Testing;Tissues;tool;Toxic effect;Underrepresented Populations;Work

PROJECT_TITLE: Effects of TDP-43 Proteinopathy on Retrotransposon Activation and Cell-Type Specific Vulnerability in a Mammalian Model of Alzheimer's and Related Dementias


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Heme enzymes catalyze a broad range of biological transformations important for immune system regulation, antibiotic production, and hormone biosynthesis. Elucidating their mechanistic behavior is therefore critical to understanding these pathways and developing new methods to combat disease. This proposal attempts to determine the structural basis for, and dynamics associated with, unusual heme-dependent enzyme reactions important for the development of new pharmaceuticals and anticancer therapeutics.

PI_NAMEs: DAVIS, KATHERINE MARIE (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Unraveling the dynamics that enable unusual heme enzyme reactivity


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Medulloblastoma (MB) is the most common malignant brain tumor occurring in children. Stanford therapies are non-targeted and exceedingly toxic and outcomes for children with relapsed/refractory MB are very poor. This proposal will develop and test a novel, potency enhanced GPC2-CAR T cell therapy that shows impressive efficacy in preclinical models of MB in patients with relapsed/refractory MB.

PI_NAMEs: FELDMAN, STEVEN A;MACKALL, CRYSTAL  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Amendment;Antigen Receptors;Antigens;antitumor effect;arm;B-Lymphocytes;Blood Component Removal;Brain Neoplasms;cancer cell;CAR T cell therapy;Cell surface;Cells;cellular transduction;Child;Childhood;Childhood Brain Neoplasm;Childhood Malignant Brain Tumor;Childhood Solid Neoplasm;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;comparative efficacy;CRISPR/Cas technology;Cytotoxic agent;Data;density;design;Development;diffuse midline glioma;disorder control;DNA;Dose;efficacy evaluation;engineered T cells;Engineering;Enrollment;Epidermal Growth Factor Receptor;exhaustion;Funding;Gene Delivery;Genes;Genetic Recombination;genotoxicity;Glypican;Goals;high risk;Human;Immunotherapy;improved;Institutional Review Boards;Knock-in;Lentivirus;life span;Lymphoblastic Leukemia;Lymphoma;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;manufacture;Mediating;Medulloblastoma;Molecular;Morbidity - disease rate;Multiple Myeloma;Nature;Neuroblastoma;next generation;novel;Outcome;overexpression;participant enrollment;Patient-Focused Outcomes;Patients;phase I trial;Plasma Cells;postnatal;Pre-Clinical Model;Process;programs;Publishing;Recurrent disease;Refractory;Refractory Disease;Relapse;research clinical testing;Resistance;Retroviridae;Safety;safety assessment;Science;Signal Transduction;Solid;Solid Neoplasm;success;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;Tissues;Toxic effect;trial design;tumor;Variant;vector;Viral;Work

PROJECT_TITLE: Next Generation GPC2-CARs for Medulloblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-F (O1)]