NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Tens of millions of individuals living with HIV-1 are taking highly active antiretroviral therapy (HAART), a long- term and life-saving treatment comprising the use of multiple antivirals that prevent HIV-1 infection by targeting essential enzymes involved in the viral replication cycle. Our lab previously reported a potent non-nucleoside reverse transcriptase inhibitor (NNRTI), JT-4-173, that binds at the typical NNRTI-binding site but inhibits the virus through a previously undescribed process that is unique to this compound. Here, I aim to characterize the novel mechanism of action of JT-4-173, which can both further our understanding of HIV-1 reverse transcriptase biology and aid in the development of future generations of HAART.

PI_NAMEs: WEN, XIN  (contact)

PROGRAM_OFFICER_NAME: ZHOU, YAN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Active Sites;Adherence;Affect;Anti-Retroviral Agents;Anti-viral Agents;Base Sequence;Behavior;Binding;Binding Sites;Biochemical;Biological Assay;Biology;Catalytic Domain;Cessation of life;Clinical;common treatment;Complementary DNA;Complex;Cryoelectron Microscopy;curative treatments;Data;design;Detection;Development;DNA;DNA Binding;DNA biosynthesis;DNA-Directed DNA Polymerase;Drug resistance;drug resistant virus;Drug Targeting;ds-DNA;Effectiveness;endonuclease;Enzymes;Epidemic;experimental study;FDA approved;Foundations;Future Generations;Genome;Health Services Accessibility;Highly Active Antiretroviral Therapy;HIV;HIV-1;Hydrophobicity;improved;In Vitro;Individual;Infection;inhibitor;insight;Length;Life;Ligation;Long Terminal Repeats;medical specialties;Molecular;Molecular Conformation;Molecular Mechanisms of Action;mutant;Mutate;nanopore;non-nucleoside reverse transcriptase inhibitors;novel;Nucleic Acids;Oral;Pancreatic ribonuclease;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Polymerase;polymerization;Polymers;prevent;Primer Extension;Process;Provirus Integration;Recombinants;Reporting;Reverse Transcription;Ribonuclease H;RNA;RNA-Directed DNA Polymerase;Role;Scientist;Site;standard care;Structure;Techniques;Therapeutic;Training;training opportunity;transmission process;Treatment Protocols;Viral;viral DNA;Viral Load result;viral RNA;Virus;Virus Replication;Work;X-Ray Crystallography

PROJECT_TITLE: Characterization of JT-4-173, a Potent Antiviral that Inhibits HIV-1 by a Novel Mechanism of Action


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Data Science;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Patient Safety;Substance Misuse

ORG_CITY: AMHERST

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE The increasing incidence of patients on two or more prescription drugs creates increasing chances of nega- tive drug interactions, so improved methods for identifying and predicting deleterious, and possibly lethal drug combinations, particularly for interactions with opioids, are desperately needed. I will use a unique translational bioinformatics approach to predict adverse drug reactions for patients by leveraging: the proteins with which each drug interacts, each patient's prescription drug regimen, and patient speciﬁc demographic information. The out- come will be an effective software to predict adverse drug reactions caused by opioid related polypharmacy that will aid clinicians by optimizing prescribing practices for patient safety.

PI_NAMEs: FALLS, ZACKARY MICHAEL (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Achievement;addiction;adverse drug reaction;Affinity;Age;Aptitude;Architecture;Area;Basic Science;Benzodiazepines;Binding;Binding Proteins;Bioinformatics;Biological;Biological Assay;Buprenorphine;career;career development;Cause of Death;Cessation of life;Chemical Models;Chronic Disease;Clinical;Clinical Data;clinical decision support;Clinical Decision Support Systems;Clinical Informatics;clinical practice;Clinical Skills;clinically significant;cohort;Complement;Computer Analysis;Computer software;cost;Counseling;Creativeness;Data;Data Set;Databases;deep learning;deep learning model;design;Development;Diagnosis;Docking;Drug Combinations;drug discovery;Drug Interactions;Drug Prescriptions;Drug usage;Electronic Health Record;Environment;Ethnic Origin;Event;experience;falls;FDA approved;Financial Hardship;Funding;Gender;Goals;Grant;Graph;graph theory;Health;Healthcare Systems;High Prevalence;Human;Impaired cognition;improved;In Vitro;Incidence;individual patient;K-Series Research Career Programs;Knowledge;Knowledge acquisition;knowledge graph;medication-assisted treatment;Medicine;Mentors;Methadone;Methodology;Methods;Naltrexone;new therapeutic target;novel;novel therapeutics;Opiate Addiction;Opioid;opioid epidemic;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;Overdose reduction;Pathway interactions;patient safety;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacology;Polypharmacy;Predictive Analytics;predictive modeling;prescription opioid;Proteins;Protocols documentation;Quality of life;Race;Regimen;Relapse;relapse patients;Reporting;Research;Research Personnel;Research Proposals;ROC Curve;Sampling;Severities;side effect;Site;skills;Software Tools;standard of care;Statistical Data Interpretation;sustained recovery;Testing;Tobacco use;Training;treatment guidelines;United States;Validation;vector;Ventilatory Depression

PROJECT_TITLE: A translational bioinformatics approach to elucidate and mitigate polypharmacy induced adverse drug reactions

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Mental Health

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative While psychological stress can precipitate many cardiovascular events, and targeting those susceptible to stress-induced events in clinical trials has reduced event risk, the absence of a non-invasive metric that captures cardiac decompensation in heart failure (HF) patients has until recently impeded the identification of psychological experiences as acute precipitants that contribute to HF decompensation and hospitalization. The recent introduction of the wireless hemodynamic monitor (e.g., CardioMEMS,), implanted in the pulmonary artery to directly measure pulmonary artery pressure (PAP) provides a unique opportunity to identify and risk stratify HF patients for whom stress may contribute to HF exacerbation. We propose to leverage this new technology to: (Aim 1a) determine the effect of acute laboratory stress on momentary PAP, (Aim 1b) determine the relationship of daily stress and negative emotion to daily PAP as captured by ecological momentary assessment, and, (Aim 2) determine the relationship of stress-induced PAP increase to HF exacerbation.

PI_NAMEs: BURG, MATTHEW M;LAMPERT, RACHEL  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Acute;acute stress;Admission activity;Anger;Anxiety;Arrhythmia;Biological Markers;Cardiac;Cardiovascular system;Chronic;Chronic stress;Clinical;Clinical Trials;Congestive Heart Failure;cost;Data;Devices;Disease Marker;Ecological momentary assessment;EFRAC;Emotions;Event;experience;Heart failure;hemodynamics;Heterogeneity;high risk;Hospitalization;Hostility;Impairment;Implant;improved;innovation;Intervention;Laboratories;Left Ventricular Dysfunction;Life;Measurement;Measures;Medical;Mental Depression;Monitor;Morbidity - disease rate;mortality;Myocardial Ischemia;new technology;Outpatients;Patient-Focused Outcomes;Patients;pharmacologic;Physiological;Predisposition;preservation;prevent;Protocols documentation;Psyche structure;psychologic;Psychological Stress;Psychosocial Assessment and Care;Psychosocial Factor;pulmonary arterial pressure;Pulmonary artery structure;Quality of life;Randomized;Research;response;Risk;risk stratification;Severity of illness;Signal Transduction;sleep quality;smartphone application;Stress;Syndrome;technological innovation;Technology;United States Centers for Medicare and Medicaid Services;wireless

PROJECT_TITLE: Stress and Congestive Heart Failure:  A mechanistic clinical trial

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Violence Against Women;Violence Research;Women's Health Research

ORG_DEPT: PSYCHIATRY

ORG_STATE: GA

PHR: PROJECT NARRATIVE While prior studies have reported worse symptoms in women following traumatic brain injury, a neurobiological basis for this sex difference has not been thoroughly examined, particularly in individuals who sustained a TBI during a traumatic event. The proposed study aims to characterize sex differences in white matter integrity and resting-state functional connectivity and how these connectivity metrics relate to symptoms and quality of life. Findings will inform our understanding of sex differences in brain connectivity, how connectivity relates to symptoms, and the influence of estradiol levels in trauma-exposed individuals with TBI, helping identify more precise intervention windows and novel therapeutic targets.

PI_NAMEs: HUIBREGTSE, MEGAN E (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Accident and Emergency department;Acute;acute stress;Address;Affect;American;Animals;Antiinflammatory Effect;associated symptom;Astrocytes;Attention;Award;Axon;biological adaptation to stress;Biometry;Blood specimen;Brain;Brain Concussion;Brain Injuries;career;Chronic Post Traumatic Stress Disorder;Chronic stress;cohort;Complex;Congresses;Consensus;Craniocerebral Trauma;Data;Data Reporting;Data Science;Data Set;decrease resilience;depressive symptoms;Diagnosis;Diffusion Magnetic Resonance Imaging;Dimensions;Discipline;DSM-V;Estradiol;Exhibits;experience;Extinction;falls;Female;female sex hormone;Fright;Functional disorder;Functional Magnetic Resonance Imaging;Glial Fibrillary Acidic Protein;Goals;Head;Headache;health disparity;health related quality of life;Health Surveys;Hormonal;Hormones;Hour;Human;Impairment;Individual;Injury;Intermediate Filament Proteins;Intervention;intimate partner violence;Investigation;Knowledge;Life;Light;Literature;Longitudinal Studies;male;Masks;Measures;Mechanics;Mediating;Mediator;medical attention;member;men;Menstrual cycle;Mental Depression;Mental Health;mental state;Mentors;mild traumatic brain injury;Military Personnel;neural circuit;neural correlate;Neurobiology;Neuroendocrinology;neuroimaging;neuroimaging marker;neuroprotection;neuropsychiatry;Neurosciences Research;neurosteroids;new therapeutic target;novel;Outcome;Participant;Patient Recruitments;Patient Self-Report;Patients;Perimenopause;Persons;physical assault;Physical Medicine;Population;post-doctoral training;post-trauma;Post-Traumatic Stress Disorders;pre-clinical research;Predisposition;Prevalence;Psychopathology;psychosocial stressors;Qualifying;Quality of life;Questionnaires;recruit;Reporting;reproductive;Research;Research Personnel;response;Rest;Risk;Risk Factors;Role;Sampling;sex;Sex Differences;sexual assault;Signs and Symptoms;Site;Sports;Stress;Symptom Burden;Symptoms;TBI Patients;Time;tool;Training;Trauma;trauma exposure;Traumatic Brain Injury;traumatic event;United States;Vehicle crash;violence against women;Visual;white matter;Woman;women's outcomes

PROJECT_TITLE: Sex differences in traumatic brain injury: Neural circuit mediators of overlapping stress and physical effects


ADMINISTERING_IC: ES

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: PITTSBURGH

ORG_NAME: STEELWORKER CHARITABLE/EDUCATIONAL ORG

ORG_STATE: PA

PHR: DOE: Project Narrative The Tony Mazzocchi Center (TMC) will conduct 1,430 workshops that will reach 28,900 DOE site workers, Tribal members and community residents with 355,200 hours of training over the proposed five-year grant from 2020-2025. To meet our training goals, TMC has direct access to 3,742 USW and CWA members employed at DOE sites; to other employees located at 12 DOE Nuclear Weapons Complex sites; and to community stakeholders including Native American Tribe members, local vocational schools, fire departments, and community organizations. We will conduct required HAZWOPER courses as well as a range of other classes, including radiation worker safety, industrial hygiene training, OSHA outreach training, accident investigation training, effective health and safety committee training, and disaster response training, including response to disasters related to climate change.

PI_NAMEs: FITCH, ASHLEE  (contact)

PROGRAM_OFFICER_NAME: BEARD, SHARON

PROJECT_TERMS: Accidents;Address;Alcohol consumption;Alcohols;arm;Cessation of life;Chemistry;climate change;Coeur D'Alene;college;combat;Communication;Communities;community organizations;community partners;Competence;Complex;Contractor;Credentialing;Department of Energy;Disasters;Doctor of Medicine;Doctor of Philosophy;Education;Education and Outreach;Educational Curriculum;Educational workshop;Elements;Emergency Situation;Employee;Employment;Environment;Environmental Impact;Epidemic;Evaluation;experience;Exposure to;Fire - disasters;Funding;Goals;Grant;hazard;Hazardous Waste Operations and Emergency Response;Health;Hour;Human Resources;improved;Indian reservation;Industrial Health;Industrialization;Investigation;Joints;Lead;Learning;Longterm Follow-up;Maps;Measures;meetings;member;Mental Health;Mentors;Mentorship;Mine safety;Mining;Modeling;Monitor;National Institute of Environmental Health Sciences;Native American Tribe;New York;Nuclear Weapon;Occupational;Occupational injury;Occupations;Opioid;opioid use;Participant;peer;Physicians;Plants;portability;prevent;programs;promote resilience;Radiation;Radiation exposure;radiation hazard;Radiology Specialty;Readiness;Research;Reservations;resilience;response;Rights;Risk;Risk Factors;Safety;Safety Management;Schools;Science;Site;Stigmatization;Stress;tool;Trainers Training;Training;Training Programs;tribal community;Tribal Council;Tribal group;tribal member;tribal Nation;Tribes;Umatilla;underserved community;Validation;Vocation;Vocational Education;wasting;worker safety;working group;Workplace;Yakama Indian

PROJECT_TITLE: Training At-Risk Workers and Potential Workers at Department of Energy Sites to Assess and Improve Health and Safety Conditions


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This study investigates the mechanism by which a unique group (“exceptional controllers”) are able to control HIV infection without HIV medications. We hypothesize that exceptional controllers have very low levels of virus in the lymphoid tissues, have levels of inflammation similar to people without HIV, and do not benefit from HIV medications. If these hypotheses are true, exceptional controllers might serve as a model for a treatment-free HIV “remission.”

PI_NAMEs: PELUSO, MICHAEL JOSEPH (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acceleration;adaptive immune response;Address;antiretroviral therapy;aspirate;Biometry;Biopsy;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Characteristics;Chronic;circulating biomarkers;Clinic;Clinical;clinical translation;cohort;Communities;Cross-Sectional Studies;Development;Disease Progression;Disease remission;DNA;Exhibits;experimental study;Fibrosis;Foundations;Frequencies;Funding;Future;Genetic Transcription;Genome;Goals;HIV;HIV Infections;Image;imaging approach;immune activation;Immune system;Immune System Diseases;Immunologics;Individual;Inflammation;Inflammatory;inflammatory marker;Innate Immune Response;Intercept;interest;Interruption;Laboratories;Lymph Node Tissue;Lymphoid;Lymphoid Tissue;Magnetic Resonance Imaging;Measurable;Measures;Methods;microbial;Modeling;Monitor;Morbidity - disease rate;mortality;novel;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phenotype;Positioning Attribute;Positron-Emission Tomography;Prevalence;Process;programs;prospective;Prospective Studies;Protocols documentation;radiotracer;Residual state;Risk;RNA;Sampling;Scientist;Standardization;systemic inflammatory response;T-Cell Activation;Tissues;Training;translational physician;translational scientist;viral rebound;Viral reservoir;Viremia;Virus;Virus Replication;Work

PROJECT_TITLE: Characterizing the virologic and immunologic signatures of HIV exceptional control

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative There is a need for rapid advances in understanding the ways the sole causative agent of the sexually transmitted infection, gonorrhea, acts as a successful pathogen. This need is due to the rising rate of N. gonorrhoeae infection and an alarming rise in antibiotic resistance complicating treatment. This work will create genetic resources for the entire research field that will facilitate investigations into how this important human pathogen causes disease and facilitate the development of new treatments or vaccines.

PI_NAMEs: SEIFERT, HANK S. (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Anatomy;Antibiotic Resistance;antimicrobial;Bacteria;California;Case Study;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Competence;Complement;conditional mutant;Consensus;CRISPR interference;CRISPR library;Development;Disease;DNA;drug-resistant gonorrhea;Essential Genes;fundamental research;Funding;Gene Expression Regulation;Gene Order;Genes;Genetic;genetic resource;Gonorrhea;Grant;Human;human pathogen;Individual;Infection;innovation;International;Investigation;Knock-out;knockout gene;Knowledge;Laboratories;Letters;Libraries;Michigan;Modern 1601-history;mutant;Mutate;Neisseria;Neisseria gonorrhoeae;Neisseria lactamica;Neisseria meningitidis;Open Reading Frames;Organism;pathogen;Pathogenesis;Pathogenicity;Phylogenetic Analysis;Physiology;Plasmids;Population;R24;Reporting;Research;Research Personnel;resistance mechanism;Resource Sharing;Resources;Sexually Transmitted Agents;Sexually Transmitted Diseases;Suggestion;symposium;synthetic construct;System;Technology;transmission process;Uncertainty;Universities;vaccine candidate;Vaccines;Work

PROJECT_TITLE: A CRISPRi screen of essential genes of Neisseria gonorrhoeae

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Women and children were historically excluded from and continue to be under-represented in clinical research studies, leading to a paucity of knowledge relating to pharmacokinetics and pharmacodynamics of therapeutic agents in these populations. The IU-OSU MPRINT DMKRCC will identify data relevant to understanding maternal and pediatric physiology, pharmacology, and clinical outcomes from literature, public resources, and MPRINT collaborators, integrate data into pharmacometric models to enhance knowledge and understanding of drug disposition and response, and support drug development and therapeutics in maternal and pediatric populations. The ultimate goal of this proposal is to enhance drug safety and efficacy in maternal and pediatric patients by understanding inter- and intra-individual sources of variability.

PI_NAMEs: LI, LANG ;QUINNEY, SARA K (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: Acute;Address;Adult;Best Pharmaceuticals for Children Act;Breast Feeding;Child;Childhood;Chronic;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;Communities;Complex;Consumption;Data;data integration;data sharing;Databases;Development;drug development;drug disposition;drug distribution;drug efficacy;Drug Kinetics;Drug usage;Educational Activities;Eligibility Determination;Enrollment;Equity;Ethics;Exclusion;Exclusive Breastfeeding;FDA approved;Feedback;Fetus;Fostering;Funding;Goals;Guidelines;Health;improved;Incentives;Indiana;Individual;Infant;infant morbidity/mortality;Infrastructure;Institute of Medicine (U.S.);Knowledge;knowledge integration;Knowledge Portal;knowledgebase;Label;Lactation;Literature;Logistics;maternal morbidity;medication safety;meetings;men;Milk;Mission;Modeling;Modernization;multidisciplinary;National Institute of Child Health and Human Development;Neonatal;neonate;Ohio;organizational structure;Orphan;Outcome;outreach;pediatric patients;Pediatric Research;personalized medicine;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Pharmacology;pharmacometrics;Pharmacotherapy;physiologically based pharmacokinetics;Physiology;Population;Pregnancy;Pregnant Women;programs;Research;Research Design;research study;Research Support;Resources;response;Rheumatoid Arthritis;Risk;Science;Source;Therapeutic;Therapeutic Agents;timeline;Translational Research;United States Food and Drug Administration;United States National Institutes of Health;Universities;Vulnerable Populations;web portal;webinar;Woman;Women's study;Work

PROJECT_TITLE: The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC)


NIH_SPENDING_CATS: Bioengineering;Breastfeeding, Lactation and Breast Milk;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Women's Health Research

PI_NAMEs: LI, LANG  (contact)

PROJECT_TERMS: ABCB1 gene;absorption;Academia;Acceleration;Active Learning;Adult;Affect;American;Animals;Artificial Intelligence;Birth;Body Water;Child;Childhood;Classification;classification algorithm;clinical investigation;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Common Data Element;Communities;CYP1A2 gene;CYP2C19 gene;CYP2C9 gene;CYP2D6 gene;CYP3A4 gene;CYP3A5 gene;Cytochrome P450;Data;data access;data curation;data dissemination;data mining;data portal;data sharing;Data Sources;data visualization;deep learning;Dehydroepiandrosterone Sulfate;Development;Devices;disability;Disease;Dose;drug clearance;drug development;drug disposition;drug distribution;drug efficacy;Drug Kinetics;Drug Metabolic Detoxication;drug metabolism;Drug Receptors;Drug toxicity;Education;Enzymes;Excretory function;extracellular;Fathers;Fetal Liver;Fetus;gender difference;Glucuronosyltransferase;graphical user interface;Growth;Human;improved;Indiana;Industry;Infant;innovation;Isoenzymes;Kidney;Knowledge;knowledge base;Knowledge Portal;knowledgebase;Lactation;Literature;Location;Maternal Physiology;men;Metabolism;Modeling;neonate;novel;Ohio;Ontology;ontology development;open source;outreach;pediatric patients;Pediatrics;Performance;Pharmaceutical Preparations;Pharmacodynamics;Pharmacoepidemiology;Pharmacogenetics;Pharmacogenomics;Pharmacology;Pharmacology and Toxicology;pharmacometrics;Pharmacotherapy;Phase;Physiological;Population;portability;Pregnancy;pregnant;Process;Property;Protein Isoforms;Publishing;Reporting;Research;research and development;Research Priority;Resources;response;Retinoids;Sample Size;Tablets;Technology;Teratogens;Text;Therapeutic;Therapeutic Research;Training;Translational Research;Tubular formation;Universities;Uridine Diphosphate;Visualization software;web portal;Woman;Work

PROJECT_TITLE: Knowledge Base and Portal


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Liver Disease;Nutrition;Prevention

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because colorectal cancer is the second leading cause of cancer death in the U.S., and new treatment strategies are urgently needed. Abundant preclinical and epidemi- ologic data link lower levels of circulating vitamin D to increased risk of and mortality from colorectal cancer, but causal evidence from randomized clinical trials is needed before vitamin D supplementation can be incorporated into standard of care treatment. This proposal will provide causal evidence in support of the clinical efficacy of vitamin D supplementation in patients with colorectal cancer, as well as elucidate underlying mechanisms of action on the immune tumor microenvironment that may lead to novel combination treatment strategies with immunotherapy agents.

PI_NAMEs: NG, KIMMIE  (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: 25-hydroxyvitamin D;Address;Antineoplastic Agents;Award;Biological;Biology;Body mass index;C26 tumor;Cancer Etiology;CD3 Antigens;Cell Communication;Cell Differentiation process;Cells;Cessation of life;chemotherapy;Cholecalciferol;clinical efficacy;cohort;Collaborations;Colon;colon cancer patients;Colon Carcinoma;Colonic Neoplasms;Colorectal Cancer;colorectal cancer risk;Combined Modality Therapy;Coupled;CYP27B1 gene;cytotoxic CD8 T cells;Data;Disease;Dose;editorial;effective therapy;epidemiologic data;Epidemiology;Flow Cytometry;Funding;Gene Activation;Gene Expression Profiling;Genetic Transcription;Human;Immune;Immune checkpoint inhibitor;Immunity;Immunofluorescence Immunologic;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;Individual;Interdisciplinary Study;KRAS2 gene;Link;Malignant Neoplasms;metastatic colorectal;Metastatic Neoplasm to the Liver;Microsatellite Repeats;migration;Mixed Function Oxygenases;mortality;mouse model;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Oncogenes;participant enrollment;Patient-Focused Outcomes;Patients;Phase;phase change;phase III trial;Placebos;Plasma;pre-clinical;preclinical trial;predictive marker;Primary Neoplasm;Prognosis;programs;Progression-Free Survivals;Public Health;Publishing;randomized, clinical trials;receptor-mediated signaling;Repression;Research;Resectable;Resistance;response;Risk;Role;single-cell RNA sequencing;standard of care;supervised learning;Technology;Testing;transcriptomic profiling;treatment strategy;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells;United States;Vitamin D;Vitamin D supplementation;Vitamin D3 Receptor;Work

PROJECT_TITLE: Leveraging Novel Randomized Clinical Trials of Vitamin D Supplementation in Patients with Colorectal Cancer: Impact on Survival and Anti-Tumor Immunity

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Center for Adolescent reward rhythms and sleep (CARRS) Narrative: Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their sleep/wake preferences paired with early school start times. Many studies find that this increases the risk for substance use (SU). However, we don’t know what impact circadian rhythm and sleep disruption either together or independently have on the neuronal circuitry that controls reward and cognition, or if there are interventions that might help to prevent these changes. Our center will perform human and animal studies with the goal of understanding the important role of sleep and circadian rhythms in the vulnerability for SU in adolescents. We will also provide training and community outreach to educate scientists and the public about the importance of sleep and rhythms.

PI_NAMEs: MCCLUNG, COLLEEN A (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Academy;addiction;Adolescence;Adolescent;adolescent brain development;Adolescent Development;Adult;Affect;American;Animals;Beds;biobank;Biological;Biology;Brain;Cells;Centers of Research Excellence;Child;Chronic;circadian;Circadian desynchrony;Circadian Rhythms;Clinical;Cognition;cognitive control;Communities;Community Outreach;Complement;cortico-limbic circuits;cost effectiveness;Data;data management;Development;Discipline;Drug abuse;Education and Outreach;Electronics;Electrophysiology (science);Ensure;Environment;Environmental Risk Factor;Epidemic;experience;Funding;Future;Genetic;Goals;Grant;Health;high school;Home environment;Hormones;Human;human study;Impulsivity;Individual;innovation;Intervention;Jet Lag Syndrome;junior high school;Label;Lead;Life Style;Methods;Modeling;Molecular;Molecular Target;National Institute of Drug Abuse;neuronal circuitry;Neurons;Neurosciences;novel;Outcome;Parents;Pediatrics;peer;Phase;Phenotype;Pilot Projects;Population;preference;prevent;Prevention strategy;Process;Productivity;Psychiatry;Puberty;Public Health;Rattus;Recording of previous events;Reproducibility;Research;Research Personnel;Research Training;Resources;response;reward circuitry;Rewards;Risk;Risk Reduction;Risk Taking;Rodent;Role;Schools;Scientist;Site;Sleep;Sleep Deprivation;Sleep disturbances;social;social factors;Social Interaction;statistics;Students;Substance abuse problem;substance use;Substance Use Disorder;Synapses;System;teacher;Teenagers;Testing;therapeutic development;Therapeutic Intervention;therapy development;Time;Time Factors;Training;Training and Education;Training Programs;trait;Translational Research;United States;Universities;Variant;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Center for Adolescent Reward, Rhythms and Sleep (CARRS)


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Data Science;Maternal Health;Pediatric;Precision Medicine;Women's Health Research

PI_NAMEs: QUINNEY, SARA K (contact)

PROJECT_TERMS: Adolescent;Adult;Biological Markers;Child;Childhood;Clinical;Clinical Pharmacology;Clinical Research;Clinical Trials Design;Collaborations;Communities;Data;data integration;data quality;Data Science;Development;disability;Discipline of obstetrics;Disease;drug development;drug disposition;Education;Ethics;Goals;Guidelines;In Vitro;Indiana;Individual;Individual Differences;individual variation;Infant;innovation;insight;International;Knowledge;Knowledge Portal;knowledgebase;Lactation;life span;Link;Logistics;Maternal and Child Health;Maternal Physiology;medication administration;Methods;Modeling;Needs Assessment;Neonatal;neonate;novel;Obesity;Ohio;open source;outreach;Paper;Pediatrics;personalized pharmacotherapy;personalized therapeutic;Pharmaceutical Preparations;pharmacodynamic model;Pharmacogenomics;pharmacokinetics and pharmacodynamics;Pharmacology;Pharmacology Study;pharmacometrics;Pharmacotherapy;physiologically based pharmacokinetics;Physiology;Play;Population;Postpartum Period;precision medicine;Precision therapeutics;preclinical study;Pregnancy;pregnant;Pregnant Women;repository;Research;Research Design;Research Personnel;Research Priority;Resources;response;Role;Services;Source;System;Therapeutic;Therapeutic Research;Time;tool;Training;treatment response;Universities;Woman;Work

PROJECT_TITLE: Pharmacometrics and Clinical Trial Design Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Pediatric;Prevention;Sleep Research;Substance Misuse

PROJECT_TERMS: Address;Administrative Efficiency;Administrator;Adolescence;Adolescent;Adolescent Development;adverse outcome;Affect;Ally;American;Area;Basic Science;Behavior;Behavioral;Brain;career development;Center for Translational Science Activities;circadian;Circadian desynchrony;Circadian Rhythms;Clinical;Clinical Research;cognitive control;Communication;Communities;Data;data resource;Dedications;Development;Doctor of Philosophy;Drug abuse;early adolescence;Education;Education and Outreach;Educational Activities;Educational workshop;Ensure;Evaluation;experience;experimental study;Family;Funding;General Population;Goals;Human;improved;Individual;innovation;Intervention;Leadership;Longitudinal, observational study;meetings;Mental Health;Methods;Modeling;modifiable risk;Modification;National Institute of Drug Abuse;Neurosciences;novel;Outcome;outreach;pharmacologic;Phase;Phenotype;Pilot Projects;Policies;Policy Maker;prevent;Process;programs;Psychiatry;Research;Research Design;Research Personnel;Research Training;Resource Sharing;Resources;Rewards;Risk;Risk Factors;Risk Reduction;Rodent;Role;Schedule;school district;Schools;Senior Scientist;Sleep;Societies;Structure;Substance administration;substance use;Substance Use Disorder;Techniques;Teenagers;Training;Training and Education;training opportunity;Training Programs;trait;United States National Institutes of Health;Universities;web site;Work;young adult

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Genetics;Pediatric;Sleep Research;Substance Misuse

PI_NAMEs: CLARK, DUNCAN B. (contact)

PROJECT_TERMS: 15 year old;Acute;addiction;Adolescence;Adolescent;Adolescent Development;Affect;Age;animal resource;Animals;Behavioral;behavioral phenotyping;biobank;Biological;Biological Specimen Banks;Brain;Breeding;Center for Translational Science Activities;Characteristics;Chronic;circadian;circadian biology;Circadian desynchrony;Circadian Dysregulation;Circadian Rhythms;Clinical;cognitive control;cognitive development;cohort;Collection;Communities;data management;data quality;Enrollment;Ensure;Ethics;Fibroblasts;follow-up;Foundations;Future;Genetic;Genetic Heterogeneity;genome wide association study;Goals;Human;human tissue;Impaired cognition;Infrastructure;innovation;Intervention;Investigation;Laboratories;Magnetic Resonance;Measures;Modeling;Molecular;Molecular Profiling;National Institute of Drug Abuse;Neurosciences;novel;Participant;Phase;Phenotype;Physiological;Procedures;programs;quality assurance;Rattus;recruit;repository;Reproducibility;Research;Research Project Grants;Research Subjects;Research Support;Resources;Rewards;Risk;Risk Reduction;Rodent;Rodent Model;Sampling;Schools;screening;Services;Sleep;Sleep Deprivation;Sleep disturbances;Sleep Fragmentations;statistics;Study models;substance use;Substance Use Disorder;Teenagers;Tissue Banks;Tissue Sample;trait;translational research program;Universities;young adult

PROJECT_TITLE: Phenotyping and Biobanking Core


NIH_SPENDING_CATS: Cystic Fibrosis;Lung;Orphan Drug;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PUBLIC HEALTH STATEMENT – OVERALL Failures of the mucus clearance system can produce consequences for the US population in the context of susceptibilities to inhaled infectious agents and environmental toxins. In addition, failure of the mucus clearance system produces a spectrum of muco-obstructive lung diseases, including COPD, asthma, non-CF bronchiectasis, and the rare genetic diseases cystic fibrosis and pulmonary ciliary dyskinesia. There is a great need to elucidate the normal structure and function of mucins to understand their roles in lung health and to develop strategies for the treatment of chronic failures of mucus clearance, i.e., patients with muco-obstructive diseases.

PI_NAMEs: BOUCHER, RICHARD CHARLES (contact);RUBINSTEIN, MICHAEL

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Air;airway surface liquid;aqueous;Asthma;Binding;Biochemical;Biochemistry;Biological;Biology;biophysical properties;Biophysics;Biostatistics Core;Bronchiectasis;Cactaceae;Characteristics;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Cilia;Ciliary Motility Disorders;Claw;combat;Communicable Diseases;crosslink;Cystic Fibrosis;Development;dimer;Disease;Distal;DNA;Doctor of Philosophy;effective therapy;Electrons;Electrostatics;Elements;Ensure;Failure;fluid flow;Functional disorder;Gel;Genes;genetic approach;Genetic study;Geometry;Gland;Goals;Health;Host Defense;Human;Hydration status;Hydrophobicity;Image;improved;In Vitro;in vivo;Infectious Agent;Inhalation;Investigation;Knowledge;Left;Length;Lung;Lung Diseases;lung health;Measurement;Membrane;Microscopic;Molecular;Molecular Biology;Morphology;Mucins;Mucolytics;Mucous body substance;mucus clearance;mucus-associated lung diseases;Mus;Nature;neutrophil;novel;novel therapeutics;Obstruction;Outcome;Pathogenesis;Patients;Polymers;Population;Power stroke;Predisposition;Property;Public Health;Pump;Quality Control;rare genetic disorder;Reagent;Recording of previous events;Regulation;Research;Research Personnel;respiratory;Respiratory Disease;Respiratory Mucin;Risk;Role;Series;Skin;Slide;Stretching;Structure;Submucosa;Surface;System;Tandem Repeat Sequences;Testing;Therapeutic;Therapeutic Agents;therapy development;Toxic Environmental Substances;Toxin;transmission process;treatment strategy;viscoelasticity;Water;Work

PROJECT_TITLE: Multi-Scale Investigations of Respiratory Mucus/Mucin Structure and Function in Health and Disease

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(MA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Sleep Research;Substance Misuse

PI_NAMEs: WALLACE, MEREDITH JOANNE LOTZ (contact)

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;Adolescent Development;Affect;American;analytical method;Area;Behavioral;biobank;Biometry;circadian;Circadian desynchrony;Circadian Rhythms;Clinical;cognitive control;Collaborations;Communities;Computational Biology;Data;Data Analyses;data integration;data management;data quality;Data Security;data standards;Databases;Deposition;Development;Doctor of Philosophy;early adolescence;Education;Educational workshop;Ensure;Family;Goals;high dimensionality;Human;Human Genetics;improved;Individual;innovation;Intervention;Manuscripts;Mass Spectrum Analysis;Methodology;Methods;Modeling;modifiable risk;multidimensional data;multiple omics;Nature;novel;Outcome;pharmacologic;Phase;Phenotype;prevent;Process;professor;Proteomics;Protocols documentation;Psychiatry;random forest;Reporting;Reproducibility;Research;Research Design;Research Personnel;reward circuitry;Rewards;Risk;Risk Factors;Risk Reduction;RNA analysis;Rodent;Security;Services;Sleep;Sleep Deprivation;Societies;Statistical Data Interpretation;Statistical Methods;statistics;Substance abuse problem;substance use;Substance Use Disorder;supervised learning;Systems Biology;Teenagers;Testing;therapy development;Training;trait;transcriptome sequencing;Universities;Work;young adult

PROJECT_TITLE: Data Management and Statistics Core


NIH_SPENDING_CATS: Data Science;Patient Safety;Pediatric

PROJECT_TERMS: Acceleration;Acute;Area;Bioinformatics;Childhood;clinical care;Clinical Pharmacology;Collaborations;Communities;Community Surveys;Data;Data Analyses;data dissemination;Data Science;drug development;Education;Educational workshop;Focus Groups;Fostering;Goals;Health;improved;Indiana;Individual;innovation;Knowledge;Link;Medicine;meetings;member;Modeling;Monitor;National Institute of Child Health and Human Development;next generation;Ohio;online tutorial;outreach;pediatric pharmacology;Pediatric Research;Performance;Persons;Pharmacogenomics;Pharmacology;pharmacometrics;Privatization;Publications;Research;Research Personnel;Resources;Science;scientific hub;skills;social media;success;Surveys;symposium;Therapeutic;Therapeutic Research;tool;Training;training opportunity;Training Programs;Translational Research;Universities;virtual;web site;webinar

PROJECT_TITLE: Outreach, Dissemination, and Training Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Neurosciences;Pediatric;Prevention;Sleep Research;Substance Misuse

PI_NAMEs: FRANZEN, PETER L (contact)

PROJECT_TERMS: actigraphy;Adolescence;Adolescent;Adolescent Development;Affect;Age;Animals;awake;Bed rest;Beds;Behavior Control;behavior test;Behavioral;Binding;Body Temperature;brain control;Cells;circadian;Circadian desynchrony;Circadian Rhythms;Clinical;Cognitive;cognitive control;Complement component C1;Development;Developmental Process;diaries;dietary supplements;Drowsiness;effective intervention;Electroencephalography;Enrollment;Environment;Environmental Risk Factor;Female;Financial cost;follow-up;Functional Magnetic Resonance Imaging;Grant;Hair follicle structure;Health Care Costs;Home;Hour;Human;Incidence;indexing;Individual;innovation;Intervention;Laboratories;Laboratory Study;Life;Light;Link;Machine Learning;Masks;Measures;Melatonin;Modeling;modifiable risk;Molecular;molecular marker;Moods;novel;nutrition;Participant;Patient Self-Report;Performance;Periodicity;Phase;Physical activity;Physiological;Physiology;Polysomnography;Posture;Predictive Factor;Prevention;Protocols documentation;recruit;Reporting;Resources;response;Rewards;Risk;Risk Factors;Risk Reduction;Saccades;Salivary;Sleep;Sleep Deprivation;Sleep disturbances;sleep pattern;sleep regulation;Slow-Wave Sleep;social factors;Social Interaction;societal costs;statistics;stem;substance use;Substance Use Disorder;Surveys;System;Teenagers;Testing;trait;trend;vigilance;Wakefulness;young adult;Youth

PROJECT_TITLE: Circadian rhythms and homeostatic sleep regulation during adolescence: Implications for reward, cognitive control, and substance use risk


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE: The clearance of apoptotic cells, termed “efferocytosis”, is essential for the maintenance of tissue homeostasis. Although much is known about the mechanisms of apoptotic cell recognition and uptake, how efferocytes process the metabolic cargo they receive during apoptotic cell uptake and how they hijack the endocytic machinery for this process are underexplored. In this R35 MIRA proposal, we will determine the novel mechanisms by which efferocytes degrade apoptotic cells and remove excess cholesterol released from digested apoptotic cells to maintain cellular homeostasis.

PI_NAMEs: CAI, BISHUANG  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Acceleration;Anabolism;Apoptosis;Apoptotic;Arterial Fatty Streak;ATP binding cassette transporter 1;Binding;Biochemistry;C-terminal;Carrier Proteins;Cell surface;Cells;Cellular biology;Cholesterol;cholesterol control;Cholesterol Homeostasis;chronic inflammatory disease;CRISPR screen;Cytoskeleton;Data Set;Digestion;Disease;Docosahexaenoic Acids;Endocytosis;Epitopes;Event;functional genomics;genome-wide;Homeostasis;immunogenic;Inflammation;Inflammation Mediators;Inflammatory Response;Intracellular Transport;Learning;Macrophage;Maintenance;Mediating;Mediator;Membrane;Metabolism;mouse genetics;Necrosis;novel;novel therapeutic intervention;Phagocytes;Phagocytosis;Physiological;Process;receptor;Resolution;Role;Signal Transduction;single-cell RNA sequencing;Tertiary Protein Structure;tissue repair;Tissues;trafficking;uptake;vesicle transport

PROJECT_TITLE: Efferocytosis meets endocytosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Influenza vaccination is strongly recommended for hospitalized children, many of whom are at high-risk for influenza infection and associated complications, yet approximately half fail to receive this needed vaccine before hospital discharge. This project will establish a stakeholder-informed, standardized inpatient influenza vaccination program and examine its effectiveness in increasing influenza vaccination rates of hospitalized children across diverse U.S. pediatric health systems. The program has important public health implications for influenza vaccine delivery to high-risk children, with indirect benefits to other vulnerable populations including the elderly, and could be expanded to other needed vaccines, patient populations, and healthcare settings.

PI_NAMEs: HOFSTETTER, ANNIKA M;RAO, SUCHITRA  (contact)

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: The INFLUENTIAL Trial- Inpatient FLU Vaccination Program Effectiveness: National Trial Implementing Best Practices And Learning Collaboratives

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Neurosciences;Pediatric;Prevention;Sleep Research;Substance Misuse

PI_NAMEs: HASLER, BRANT P. (contact)

PROJECT_TERMS: actigraphy;Acute;Adolescence;Adolescent;Adolescent Development;Affect;Age;Animals;attentional control;Behavioral;biobank;Biological;brain circuitry;Caffeine;Characteristics;circadian;Circadian desynchrony;Circadian Rhythms;Clinical;Cognitive;cognitive control;cognitive task;comparison control;Complement;Control Groups;data management;Development;disorder risk;effective intervention;Exhibits;experimental study;Female;Financial cost;follow up assessment;follow-up;Goals;Hair follicle structure;Health Care Costs;high risk;Home;Human;Impaired cognition;improved;improvement on sleep;Incidence;Individual;Individual Differences;innovation;Intervention;Laboratories;Lead;Light;Longitudinal Studies;Machine Learning;Measures;Mediator;Melatonin;Methods;Modeling;modifiable risk;Molecular;neural;neurobehavioral;neuroimaging;novel;Observational Study;Participant;Patient Self-Report;Periodicity;Phase;Phenotype;Polysomnography;Predictive Factor;Prevention;Randomized;reduced substance use;Reporting;Resources;Rewards;Risk;Risk Factors;Risk Reduction;Salivary;Schedule;Schools;Self Assessment;Sleep;societal costs;statistics;Substance abuse problem;substance use;Substance Use Disorder;Synapses;System;Systems Development;Teenagers;Testing;trait;Visit;Work;young adult;Youth

PROJECT_TITLE: Circadian rhythms, sleep, and substance use risk during adolescence:  Observational, experimental, and longitudinal studies


NIH_SPENDING_CATS: Data Science;Pediatric

PROJECT_TERMS: Address;Administrative Coordination;Award;Childhood;Clinical Pharmacology;Clinical Trials;Clinical Trials Design;Collaborations;Communication;Communities;Data;data dissemination;data integration;data modeling;Data Science;data sharing;Development;Developmental Biology;drug development;Education and Outreach;Educational Activities;Ensure;Funding;Goals;Indiana;Interdisciplinary Study;Knowledge;Knowledge Portal;knowledgebase;Logistics;Maternal Health;meetings;member;Modeling;Modification;National Institute of Child Health and Human Development;novel;Ohio;outreach;Persons;pharmacometrics;Procedures;programs;Research;Research Activity;research and development;Research Design;Research Priority;Research Project Grants;Resources;Science;Structure;Therapeutic;timeline;Training;Training Activity;Translational Research;United States Centers for Medicare and Medicaid Services;United States Food and Drug Administration;United States National Institutes of Health;Universities;virtual;Work;working group

PROJECT_TITLE: Logistics Core


PROJECT_TERMS: addiction;Adolescence;Adolescent;Adolescent Development;ARNTL gene;Behavior;Behavior Therapy;Behavioral;Biological Assay;Biological Factors;Brain region;Cell Culture Techniques;Cells;circadian;Circadian desynchrony;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical;Clinical Research;Clinical Trials;Cognition;cognitive control;Collecting Cell;Cultured Cells;Data;Developmental Process;Electrophysiology (science);Environmental Risk Factor;experience;Future;Gene Expression;Genetic;Goals;Hair follicle structure;Human;human subject;Impulsivity;Individual;interest;Intervention;Jet Lag Syndrome;Lead;Luciferases;Machine Learning;Measurement;Measures;Methods;Modeling;Molecular;molecular clock;Molecular Target;neuronal circuitry;novel;Periodicity;personalized medicine;pharmacologic;Phase;Phenotype;Phototherapy;Physiological;protein expression;Proteomics;Protocols documentation;Rattus;response;reward circuitry;Rewards;Risk;risk mitigation;Rodent;Rodent Model;Rotation;Sampling;Skin;Sleep;Sleep disturbances;Sleep Fragmentations;social;social factors;Substance abuse problem;substance use;Substance Use Disorder;substance use prevention;Teenagers;Testing;Therapeutic;trait;transcriptome sequencing;translational study;United States;Variant;vulnerable adolescent;young adult

PROJECT_TITLE: Molecular rhythms and substance abuse vulnerability in adolescents


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Neurosciences;Pediatric;Sleep Research;Substance Misuse

PI_NAMEs: TORREGROSSA, MARY M (contact)

PROJECT_TERMS: abuse liability;Acute;addiction;Adolescence;Adolescent;Affect;Attention;Behavior;Behavior assessment;Behavioral;behavioral study;biobank;Brain;Calcium;Chronic;circadian;Circadian desynchrony;Circadian Dysregulation;Circadian Rhythms;Clinical;Cognition;cognitive control;cognitive function;cognitive testing;Complement;Conflict (Psychology);cortico-limbic circuits;Data;Development;Dopamine;Drug abuse;drug action;Drug usage;early adolescence;Electrophysiology (science);emerging adult;Environmental Risk Factor;Ethics;executive function;Exhibits;experience;Female;Fiber;Functional disorder;Genetic;Human;Impulsivity;in vivo;indexing;Individual;Individual Differences;Intervention;male;Marijuana;Measures;Modeling;Molecular;neural;neural circuit;neurodevelopment;neuroimaging;Neurons;Nicotine;nicotine self-administration;Nucleus Accumbens;Outcome;Parents;Pattern;peer;Persons;Pharmaceutical Preparations;Phase;Phenotype;Photometry;preference;Prefrontal Cortex;Prevention strategy;Rattus;Reaction Time;Rewards;Risk;risk minimization;Risk Taking;Role;Schools;sedative;Self Administration;sensor;Sleep;Sleep Deprivation;Sleep disturbances;substance use;Substance Use Disorder;synergism;Testing;Tetrahydrocannabinol;trait;Variant

PROJECT_TITLE: Determining the role of adolescent sleep and circadian factors on risk for substance use in a rat model


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Precision Medicine;Social Determinants of Health

PI_NAMEs: LIN, SIMON M. (contact)

PROJECT_TERMS: Acceleration;Address;Adverse drug event;Ambulatory Care;Architecture;Area;behavioral phenotyping;behavioral study;Child;Childhood;Clinical;Clinical Data;clinical phenotype;Clinical Research;Clinical Sciences;Code;Collaborations;Data;data access;Data Analytics;Data Collection;data infrastructure;data integration;data management;data quality;data resource;data reuse;Data Set;data sharing;data standards;Disparity;drug development;drug disposition;drug efficacy;Electronic Health Record;Eligibility Determination;Environment;epidemiology study;Event;Exclusion;experience;Fostering;Genomics;Goals;Health;health disparity;health equity;Health Services Accessibility;Health system;Healthcare Systems;improved;Indiana;Individual;Informatics;Information Systems;Information Technology;Infrastructure;innovation;inpatient service;Intervention Studies;Knowledge;Literature;Measurable;Mediating;medication safety;member;Modeling;multidisciplinary;Natural Language Processing;novel strategies;Ohio;Outcome;Patients;Pediatric Hospitals;pediatric patients;Pediatric Research;Pediatrics;Pharmaceutical Preparations;Pharmacogenomics;pharmacokinetics and pharmacodynamics;Pharmacology;pharmacometrics;Pharmacotherapy;Physiology;Population;Population Study;Precision Health;Precision therapeutics;Process;Productivity;Recommendation;Reproducibility;Research;Research Personnel;research study;Resources;response;Secure;Services;social;social determinants;social health determinants;Source;Structure;Technology;Text;Therapeutic;Therapeutic Agents;Translational Research;Translations;Universities;user-friendly;Vision;Visit;Woman;Work

PROJECT_TITLE: Real World Evidence Core


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: PROJECT NARRATIVE  The goal of this project is to develop and test several vaccine candidates against domestic and exotic emerging and re-emerging tickborne encephalitis and hemorrhagic fever viruses classified as NIAID Category A or C Priority Pathogens.

PI_NAMEs: VERARDI, PAULO H (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acceleration;Accounting;Address;Agriculture;Ambylomma americanum;Animal Model;Antibody titer measurement;Antigens;arthropod-borne;Asia;Asian;biocontainment facility;Categories;Cell Culture Techniques;cell mediated immune response;climate change;Connecticut;Containment;Crimean-Congo Hemorrhagic Fever Virus;cross immunity;design;Development;Disease;DNA;efficacy testing;Electron Microscopy;Emerging Communicable Diseases;Encephalitis;Ensure;environmental change;experimental study;Funding;Generations;Genes;Goals;Habitats;Haemaphysalis longicornis;Heartland virus;hemorrhagic fever virus;Human;Immune response;Immunocompetent;immunogenicity;Infectious Diseases Research;Interferon Receptor;Investigation;Knockout Mice;Label;Modeling;mouse model;Mus;National Institute of Allergy and Infectious Disease;neutralizing antibody;New England;Omsk hemorrhagic fever virus;Orthobunyavirus;Play;Powassan virus;poxvirus vectors;prevent;Prevention;priority pathogen;protein expression;Public Health;rapid technique;Regimen;Reporting;research and development;Risk;Serum;Severe Fever with Thrombocytopenia Syndrome Virus;Subunit Vaccines;Testing;tick feeding;tick transmission;tick-borne;Tick-Borne Diseases;Tick-Borne Encephalitis;Tick-Borne Encephalitis Virus;tick-borne flavivirus;tick-borne virus;Ticks;transmission process;Universities;US State;Vaccinated;vaccine candidate;vaccine development;vaccine efficacy;vaccine evaluation;Vaccines;Vaccinia virus;vaccinia virus vector;vector induced;Vector-transmitted infectious disease;Viral;Viral Genes;Viral Hemorrhagic Fevers;Viral Vector;Virus;virus classification;Virus Diseases;Virus-like particle;Visualization;Western Blotting

PROJECT_TITLE: Vaccines for Prevention of RG3 and RG4 Emerging Tickborne Viral Diseases


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Lung;Precision Medicine;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The goal of this project is to support research that will help us to understand how COPD progresses with the ultimate goal of providing patients better information about their disease course and personalized treatment options. This project will also provide continued support for a training program at the University of Michigan for junior investigators interested in conducting patient oriented research in COPD, focusing in particular on trainees who are currently underrepresented in this field of research including women and minorities.

PI_NAMEs: HAN, MEILAN K (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Adult;Age;aged;aging population;Airway Disease;airway obstruction;analytical method;Area;Award;Belief;career;career development;Chest;Chest imaging;Chronic Obstructive Pulmonary Disease;Clinical;Clinical and Translational Science Awards;cohort;Collaborations;Data;Development;Diameter;Disease;disease classification;disease heterogeneity;Disease Marker;Disease Progression;disorder risk;Early identification;Education;Ethnic Origin;Evolution;expectation;experience;Faculty;former smoker;Funding;Gases;Goals;graduate student;Grant;Health;Heterogeneity;imaging biomarker;improved;Individual;Infrastructure;interest;Lesion;Life;Life Cycle Stages;life span;Lung;Lung Diseases;Maps;Mentors;Michigan;Mid-Career Clinical Scientist Award (K24);middle age;Minority;Mission;mortality;multidisciplinary;National Heart, Lung, and Blood Institute;novel;Older Population;Outcome;Pathologic;Pathway interactions;patient oriented research;Patients;personalized medicine;Physicians;Physiological;Prevention education;programs;Pulmonary Emphysema;pulmonary function;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;racial diversity;radiological imaging;recruit;Research;Research Personnel;Research Support;Research Training;Resources;response;responsible research conduct;Risk;Scientist;Secure;serial imaging;Severity of illness;Site;skills;small airways disease;Smoke;Smoker;Symptoms;targeted treatment;Techniques;Time;Training;training opportunity;Training Programs;Universities;Visit;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Defining Pathways in COPD Patient Oriented Research

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Pediatric;Sleep Research;Substance Misuse

PI_NAMEs: HUANG, YANHUA H (contact)

PROJECT_TERMS: Acute;Adenosine;Adolescence;Adolescent;Adolescent Development;Affect;AMPA Receptors;Anhedonia;Behavior;behavior test;Behavioral;behavioral phenotyping;cellular targeting;cholinergic;Chronic;circadian;Circadian desynchrony;Circadian Dysregulation;circadian regulation;Circadian Rhythms;Cognitive;cognitive control;Collaborations;Corpus striatum structure;cortico-limbic circuits;Cues;Diurnal Rhythm;Dopamine;drug reward;drug seeking behavior;drug testing;Emotional;Evaluation;Exhibits;Gene Mutation;Glutamates;High School Student;Human;human data;human imaging;Hyperactivity;imaging study;insight;Lead;Medial;Mediating;Membrane;Modeling;Molecular;Molecular Genetics;molecular phenotype;motivated behavior;neural;Neurons;Nucleus Accumbens;Outcome;Pharmaceutical Preparations;Phase;postsynaptic;preference;Prefrontal Cortex;Publishing;Rattus;Regulation;Research Project Grants;response;reward processing;Rewards;Risk;Rodent Model;Schools;Self Administration;Site;Sleep;Sleep Deprivation;Sleep disturbances;Sleep Fragmentations;Substance abuse problem;substance use;Sucrose;Synapses;Synaptic Transmission;Teenagers;Testing;Time;trait;transmission process;Ventral Striatum;young adult

PROJECT_TITLE: Regulation of nucleus accumbens neurons by sleep and circadian rhythm


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MEMPHIS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Ethnic minorities have a severe data-disadvantage that is set to produce new health disparities as data-driven and algorithm-based biomedical research and clinical decisions become increasingly common. The proposed research addresses this challenge by discovering critical knowledge and creating open resources for a paradigm shift in multiethnic machine learning using cancer clinical omics data. This paradigm shift is expected to prevent or reduce health disparities arising from the data-disadvantage of ethnic minorities.

PI_NAMEs: CUI, YAN  (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Address;Affect;African American population;Algorithms;Archives;Artificial Intelligence;artificial intelligence model;Asian population;base;Benchmarking;Biomedical Research;cancer genomics;cancer health disparity;cancer risk;cancer subtypes;cancer type;Caucasians;Clinical;Clinical Research;Code;cohort;Cohort Studies;Computing Methodologies;Data;Data Set;database of Genotypes and Phenotypes;Databases;Diagnosis;Disadvantaged;Disadvantaged minority;disorder risk;Disparity;Distant;ethnic disparity;ethnic diversity;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;European ancestry;experimental study;genetic architecture;genome wide association study;genomic data;Genomics;Genotype;Goals;health disparity;Healthcare Systems;Hispanic Populations;improved;Individual;Inequality;innovation;Internet;Knowledge;Knowledge Management;knowledgebase;Learning;Machine Learning;machine learning method;machine learning model;Malignant Neoplasms;Medical Genetics;Minority Groups;Modeling;multi-ethnic;Multiomic Data;Outcome;Performance;phenotypic data;Population;precision medicine;Predictive Analytics;prevent;Prevention;Prognosis;Race;racial population;Reduce health disparities;Research;Research Project Grants;research study;Resources;response;Retrieval;Sampling;Scheme;secondary analysis;self-directed learning;statistics;System;Testing;The Cancer Genome Atlas;Therapeutic;training data;transfer learning;user-friendly;Work

PROJECT_TITLE: Algorithm-based prevention and reduction of cancer health disparity arising from data inequality

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PHR: Project Narrative Career development programs that focus on the retention and advancement of under-represented minority (URM) mid-career research faculty are needed to foster greater diversity in the ranks of senior investigators and institutional leaders, and ultimately of the larger biomedical workforce to address the healthcare needs of all people. We propose a career development program that unites the expertise and educational modalities of the Association of American Medical Colleges and the University of Pittsburgh's Institute for Clinical Research Education and partners with three minority serving institutions and Centers of Excellence to recruit mid-career faculty researchers on the cusp of promotion and consideration for leadership opportunities. Our yearlong program will matriculate 20 mid-career scholars per year with the aim of increasing their retention, promotion into senior ranks, attainment of leadership roles, and the longevity of their research careers.

PI_NAMEs: DAVIS, ESA M;MURRELL, AUDREY JEANETTE (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Academia;Academy;Acceleration;Address;American;Area;Association of American Medical Colleges;Biomedical Research;Capital;career;career development;Clinical Research;cohort;Decision Making;Department chair;Development;Development Plans;Discrimination;Disparity;editorial;Education;education research;Ensure;Equity;experience;Faculty;faculty research;Feeling;Fostering;Funding;Funding Opportunities;Future;Goals;Grant;Health;Healthcare;improved;Individual;innovation;Institution;Institutional Racism;instructor;Investments;Journals;Leadership;Link;Longevity;matriculation;Measures;Medical;medical schools;Medicine;Mentors;Mentorship;mid-career faculty;Minority;minority investigator;Minority-Serving Institution;Modality;Movement;Outcome;outreach;Participant;peer coaching;Personal Satisfaction;Persons;Positioning Attribute;Productivity;professional atmosphere;Program Development;programs;psychologic;Publications;recruit;Research;research faculty;Research Personnel;Resources;Role;Safety;satisfaction;Science;Self Efficacy;senior faculty;skill acquisition;skills;skills training;stem;Structure;Study Section;success;tenure track;Time;Training;Training Activity;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;virtual;Work

PROJECT_TITLE: TRANSforming Bio-medical Research & Academic Faculty through Opportunity, TRaining, & Mentorship (TRANSFORM)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Maternal Health;Maternal Morbidity and Mortality;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Pregnancy;Social Determinants of Health;Substance Misuse;Women's Health Research

PHR: Project Narrative Medication-assisted treatments (MATs) are recommended during pregnancy and postpartum for opioid use disorder (OUD) yet relapse rates remain elevated and we have limited knowledge of the factors contributing to opioid use trajectories during this critical time. The proposed study will be the first to examine the predictive role of psychosocial and parenting stress on opioid-use trajectories during pregnancy and across the postpartum period. Findings will be critical to the development of more effective evidence-based intervention and prevention approaches for pregnant women and mothers with OUD.

PI_NAMEs: RUTHERFORD, HELENA JV (contact);YIP, SARAH

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: addiction;Behavior;biobehavior;biological adaptation to stress;Birth;Brain;Brain region;Characteristics;Child;Child Rearing;cortico-limbic circuits;craving;Cues;Data;Development;Distress;Electronic Health Record;Evidence based intervention;Exhibits;Exposure to;Financial Support;Generations;Gestational Age;Health;hedonic;improved;Individual;Infant;Intervention;Knowledge;longitudinal design;Low Birth Weight Infant;Maintenance;maternal opioid use;maternal stress;Measures;Medial;medication-assisted treatment;Modeling;Mothers;Motor;Negative Valence;neural;Neurobiology;neuroimaging;neuromechanism;Neuronal Plasticity;novel;Opiate Addiction;Opioid;opioid use;opioid use disorder;Parents;Participant;Pattern;Personal Satisfaction;Pharmaceutical Preparations;Phenotype;Population;Postpartum Period;Pregnancy;pregnant;Pregnant Women;prenatal stress;Prevention;Prevention approach;Process;psychosocial;Psychosocial Assessment and Care;Psychosocial Stress;Public Health;Recommendation;recruit;Relapse;relapse risk;Reporting;Research;reward circuitry;Risk;Role;Scanning;Sensory;Shapes;Stimulus;Stress;stress reactivity;stressor;Substance abuse problem;Substance Addiction;substance use;symptomatology;Symptoms;System;Third Pregnancy Trimester;Time;treatment adherence;Treatment outcome;Withdrawal Symptom;Woman;Work

PROJECT_TITLE: Psychosocial and neurobiological stress and opioid use trajectories following pregnancy

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Emerging Infectious Diseases;Hematology;Infectious Diseases;Nanotechnology;Sepsis

ORG_CITY: RIVERSIDE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: This application is focusing to enhance the state of art of molecular diagnosis of sepsis, one of the leading public health concerns. The proposed interdisciplinary work includes new methods to isolate and concentrate bacteria from patient sample, an isothermal and amplification-free assay to identify antimicrobial strains, and a highly efficient optofluidic sensing chip to detect fluorescently labeled targets.

PI_NAMEs: DU, KE  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: accurate diagnosis;Address;advanced disease;antimicrobial;Antimicrobial Resistance;Bacteria;Bacterial Infections;bacterial resistance;Biochemistry;Biological Assay;Biological Markers;Biomedical Research;Blood specimen;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Communities;Consumption;Death Rate;Detection;Diagnosis;Disease;disease diagnosis;doctoral student;Early treatment;Emergency Situation;Engineering;Fluorescence;Foundations;Goals;Home;interdisciplinary approach;Interdisciplinary Study;journal article;Label;Laboratories;Life;Liquid substance;Malignant Neoplasms;Methods;Microfluidic Microchips;miniaturize;Molecular Diagnosis;nanodevice;nanomaterials;Nanostructures;Nervous System Disorder;nucleic acid detection;pathogen;Patients;Persons;Postdoctoral Fellow;Preparation;Prevention;programs;Property;Public Health;Publishing;rapid diagnosis;Research;Research Personnel;Resistance;response;Retrieval;Risk;Sampling;Sensitivity and Specificity;Sepsis;Septic Shock;small molecule;Students;Technology;Testing;Tissues;undergraduate student;Virus;Virus Diseases;Vision;waveguide;Whole Blood;whole blood bacteria;Work

PROJECT_TITLE: Understand and Detect Sepsis: Pathogen Isolation, Biochemistry Assay, and Optofluidic Sensing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Magnetic resonance imaging (MRI), and especially diffusion-weighted MRI (DWI) is a powerful tool for investigating the health of white matter issue in neurologic diseases. The diffusion-time dependence of the apparent diffusion coefficient in neural tissues has been recognized in several studies, yet is an underexplored aspect of DWI, particularly to uncover the microstructural features of white matter tissue. This proposal aims to reveal the microstructural features that underlie the diffusion-time dependent changes measured in neural tissue.

PI_NAMEs: HARKINS, KEVIN D (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Age;Animal Experiments;Animal Model;Axon;Brain;Characteristics;Chemical Injury;Clinical;Complex;Computer Models;Dependence;Diagnosis;Diameter;Diffusion;Diffusion Magnetic Resonance Imaging;diffusion weighted;Disease;Exhibits;experimental study;Ferrets;Geometry;Goals;Health;Heterogeneity;Histology;Human;human imaging;human subject;Image;improved;Magnetic Resonance Imaging;Measurement;Measures;Methods;Modeling;Myelin;Nervous System Disorder;neural;Neurons;Physiologic pulse;Population;Property;Protocols documentation;Rattus;Role;sex;Signal Transduction;simulation;Source;Spinal Cord;Staging;Structure;temporal measurement;Testing;three-dimensional modeling;Time;Tissue Model;Tissues;tool;Validation;Variant;Water;water diffusion;white matter;White Matter Disease;Work

PROJECT_TITLE: Uncovering the time dependent diffusion coefficient in neural tissue with MRI

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Prevention;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project narrative: Lineage plasticity is an increasingly common mechanism of resistance to targeted therapy seen in multiple solid tumors that results in universally poor patient outcomes. Using EGFR-mutant lung cancers as our model system, we will comprehensively molecularly characterize lineage plasticity using patient-derived samples and use patient-derived xenograft transformation models to genetically and pharmacologically assess putative drivers of transformation. Our goal is to inform development of novel therapeutic interventions to prevent or reverse histologic transformation.

PI_NAMEs: RUDIN, CHARLES M.;YU, HELENA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Address;Adenocarcinoma;Biological Models;bisulfite sequencing;cancer cell;cancer therapy;candidate validation;carcinogenesis;Cell Line;Cell Lineage;cell transformation;cell type;Cells;chemotherapy;Clinical;Clinical Trials;cohort;Data;Development;Disease;Disease Progression;Drug resistance;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Epigenetic Process;epigenomics;Epithelial Cells;Evolution;exome sequencing;EZH2 gene;Frequencies;Gene Expression Profile;Genetic Transcription;Genomics;Goals;high risk;Histologic;Histology;insight;interest;Intervention;Intervention Studies;Libraries;Lung Adenocarcinoma;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mediating;Microdissection;Modeling;Molecular;Molecular Analysis;mutant;Neoplasm Metastasis;notch protein;novel therapeutic intervention;oncogene addiction;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;permissiveness;pharmacologic;Pharmacotherapy;prevent;Prognosis;prospective;Proto-Oncogene Proteins c-akt;Qualifying;RB1 gene;Research;Research Infrastructure;Resected;Resistance;resistance mechanism;Sampling;single cell technology;single-cell RNA sequencing;Solid Neoplasm;Somatic Mutation;Squamous Cell;Squamous Cell Lung Carcinoma;Squamous Cell Neoplasms;System;targeted treatment;Therapeutic;Time;TP53 gene;transcriptome sequencing;transcriptomics;Translating;Translational Research;tumor;Tumor Tissue;tumorigenesis;Work

PROJECT_TITLE: Drivers of histologic transformation in EGFR-mutant lung cancer


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Narrative The proposed research will significantly advance our understanding of how human gut bacteria affect the development and progression of autoimmune and inflammatory diseases, in particular, inflammatory bowel disease (IBD). Specifically, this work will define new molecular pathways that causally connect the bacterial metabolism of bile acids (cholesterol-derived compounds that are produced by the host and metabolized by the resident microbiota) and the differentiation and function of T cells (immune cells that play critical roles in host immune homeostasis and disease). This research will lay the groundwork for the development of new therapies for autoimmune and inflammatory diseases that target the microbiota.

PI_NAMEs: HUH, JUN R. (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: adaptive immunity;Affect;antagonist;Anti-Inflammatory Agents;Autoimmune Diseases;Bacteria;Bacterial Genes;bacterial metabolism;bile acid metabolism;Bile Acids;Binding;Cell Differentiation process;Cell Physiology;Cells;cellular targeting;Cholesterol;Circulation;Colon;commensal bacteria;Crohn's disease;Data;Detergents;Development;differentiation in vitro;Digestion;Digoxin;Disease;Enzymes;Equilibrium;Feces;Foundations;gut bacteria;gut dysbiosis;gut microbes;gut microbiota;Homeostasis;Human;Immune;Immune response;Immune system;immunoregulation;in vivo;Inflammatory;Inflammatory Bowel Diseases;inflammatory modulation;Inflammatory Response;insight;intestinal barrier;Ligands;Lithocholic Acid;Liver;Maintenance;Mediating;meter;microbial;microbiota;microorganism;Molecular;Mus;Natural Products;novel;novel therapeutic intervention;novel therapeutics;Nuclear Hormone Receptors;Nuclear Orphan Receptor;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Plants;Play;Production;programs;Publishing;receptor;Regulatory T-Lymphocyte;Reporting;Research;response;Retinoic Acid Receptor;Role;screening;Shapes;Steroids;Systems Development;T cell differentiation;T cell response;T-Lymphocyte;Testing;Tissues;Ulcerative Colitis;Work

PROJECT_TITLE: Bacterial metabolites controlling Th17 and Treg cells

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: NARRATIVE Protein synthesis is a highly regulated process with the ribosome being an important antibiotic target. The goal of this project is to understand at a molecular level how the P-site tRNA regulates translation initiation, ribosome recycling, and protein synthesis quality control. To achieve our goals, we combine state-of-the-art techniques of cryo-electron microscopy (cryo-EM) and X-ray crystallography with biochemical and kinetic approaches of large functional ribosome complexes; the findings may pave the way to structure-guided design of next-generation antibiotics.

PI_NAMEs: GAGNON, MATTHIEU  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Adopted;Allosteric Site;Amino Acids;Amino Acyl Transfer RNA;Antibiotics;Anticodon;Bacteria;Base Pair Mismatch;Base Pairing;Binding;Biochemical;Biological Assay;Clinical;Codon Nucleotides;Complex;Cryoelectron Microscopy;Data;design;Development;Dissociation;Elements;Ensure;Event;experimental study;fighting;Foundations;functional outcomes;Goals;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;human pathogen;Hydrolysis;Impairment;improved;Infection;inhibitor;Initiator Codon;Initiator tRNA;insight;interdisciplinary approach;Kinetics;Knowledge;Mediating;Messenger RNA;Methionine;Methods;Molecular;molecular clock;Molecular Conformation;Molecular Machines;Movement;next generation;novel;novel therapeutics;Organism;pathogenic bacteria;Peptide Elongation Factor G;Peptides;peptidyl-tRNA;polypeptide;Positioning Attribute;Process;Prokaryotic Initiation Factor-2;Property;Protein Biosynthesis;Protein Synthesis Inhibitors;Proteins;Pseudomonas aeruginosa;Quality Control;Reading Frames;Recycling;release factor;Reporting;ribosome releasing factor;Ribosomes;Role;Sense Codon;Signal Transduction;Site;Streptococcus thermophilus;Structure;Techniques;Terminator Codon;Testing;Thermus thermophilus;Transfer RNA;translation factor;Translation Initiation;Translational Repression;Translations;Visualization;X-Ray Crystallography

PROJECT_TITLE: Structural Basis for the Allosteric Mechanisms Regulating Ribosome Function

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: WORCESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Boys are diagnosed with autism spectrum disorder (ASD) at least four times more frequently than girls, but the mechanisms underlying this bias remain largely unknown. Serotonin regulates social and emotional behaviors and abnormal function in the serotonin system has been described in ASD. In this proposal, we will elucidate the mechanism of sex-dependent serotonin function that influences social behavior.

PI_NAMEs: FUTAI, KENSUKE  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: autism spectrum disorder;Axon;Behavior;behavior test;Behavioral;Biological Process;boys;Brain;Cell Adhesion Molecules;Cognitive;Data;Development;Diagnosis;Dorsal;dorsal raphe nucleus;Electrophysiology (science);emotional behavior;Event;Female;Fiber;Genes;girls;Goals;Hippocampus;Impairment;Investigation;Knockout Mice;male;Molecular;Mus;mutant mouse model;Mutant Strains Mice;neural circuit;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;neurotransmission;new therapeutic target;Photometry;Play;postsynaptic;presynaptic;Prevalence;protein protein interaction;Proteins;raphe nuclei;Regulation;Resistance;Risk Factors;Role;sensor;Serotonergic System;Serotonin;sex;Shapes;Signal Transduction;social;Social Behavior;social influence;Social Interaction;Specific qualifier value;Structure;superresolution microscopy;Synapses;synaptic function;Synaptic Transmission;synaptogenesis;System;system architecture;Testing;transcriptome sequencing;women versus men;Work

PROJECT_TITLE: Molecular Mechanisms Underlying the sex-Depended Maturation of Modulatory Systems.

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: Project Narrative We seek to establish the Chicago Center on Musculoskeletal Pain (C-COMP), a resource-based multi- disciplinary Center to foster and support research aimed at understanding mechanisms of chronic pain in musculoskeletal (MSK) and rheumatic diseases, with the goal of better managing and preventing MSK pain.

PI_NAMEs: MALFAIT, ANNE-MARIE  (contact)

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: Acceleration;Address;Adverse effects;Affect;Analgesics;Animal Model;Area;Arthritis;behavior test;Behavioral;Behavioral Assay;Bioinformatics;career;Chicago;Chronic;chronic musculoskeletal pain;chronic pain;Clinical;collaborative environment;Communication;Communities;Consultations;disability;Disease;drug action;Education;Electrophysiology (science);Environment;Equipment;Fostering;Funding;Geography;Goals;Grant;Human;in vivo calcium imaging;Infrastructure;innovation;Interdisciplinary Study;Investigation;Knowledge;Leadership;multidisciplinary;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal Pain;Musculoskeletal System;Neuroanatomy;Neurobiology;neuronal circuitry;Neurosciences;new therapeutic target;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutic intervention;novel therapeutics;Opioid;opioid abuse;optogenetics;outreach;Pain;pain relief;Pain Research;Patients;Pharmaceutical Preparations;Physiology;Population;Postdoctoral Fellow;prevent;Productivity;programs;Protocols documentation;Research;Research Infrastructure;Research Personnel;Research Support;Resources;Rheumatism;Scientist;Services;side effect;Source;Techniques;Technology;Testing;Tissues;Training;transcriptomics;Translational Research;Translations;web site

PROJECT_TITLE: Chicago Center on Musculoskeletal Pain (C-COMP) (Overall Application)


PROJECT_TITLE: Administrative Core A


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Primary Health Care

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE Posttraumatic stress disorder (PTSD) is a significant problem among underserved populations who receive care in community health centers. Several evidence-based psychotherapies for PTSD are not practical given the time and resources required for these approaches. This research will examine whether Written Exposure Therapy (WET), a brief and well-tolerated therapy approach, delivered within collaborative primary care is effective and can be implemented successfully within a collaborative care (CC) intervention.

PI_NAMEs: MEREDITH, LISA SEIDEL (contact);SLOAN, DENISE M.

PROGRAM_OFFICER_NAME: FREED, MICHAEL C

PROJECT_TERMS: Address;Adoption;Adult;Affect;Age;Anxiety;behavioral health;Boston;Caring;Characteristics;Clinic;Clinical;Cognitive;collaborative care;community advisory board;comorbidity;Consultations;cost;Data;depressive symptoms;desensitization;design;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness validation;effectiveness/implementation design;effectiveness/implementation trial;Eligibility Determination;Environment;evidence base;Exhibits;Extinction;Eye Movements;Federally Qualified Health Center;follow-up;Fright;Gender;General Population;Geography;Health Services Accessibility;implementation context;implementation evaluation;implementation outcomes;implementation process;improved;improved outcome;Individual;Intervention;Interview;Literature;Maintenance;Managed Care;Mediating;Mediator;Medicaid;Medical;medical schools;Medicare;Mental Depression;Mental Health;Mental Health Services;Methods;Monitor;Nature;Neighborhood Health Center;Outcome;Participant;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;post intervention;Post-Traumatic Stress Disorders;Prevalence;Primary Care;primary care patient;primary care setting;primary outcome;Process;Productivity;Provider;Psychotherapy;Public Health;Quality of Care;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Resources;safety net;secondary outcome;Severities;Societies;Supervision;Symptoms;Therapeutic Intervention;Time;Training;Trauma;Treatment outcome;Underserved Population;Universities;Work;Writing

PROJECT_TITLE: Delivering Written Exposure Therapy for PTSD in Underserved Primary Care Settings


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Digital health technologies such as remote patient monitoring (RPM) have potential to improve the care of Latinx patients with hypertension (HTN), but there are barriers to both effective and equitable use in clinical practice and a need for better approaches in this population. Growing evidence supports the addition of community health workers (CHWs) to primary care teams as effective means to address social and structural determinants of health and healthcare needs to improve HTN management among Latinx patients, and supporting their digital health competency and capacity may enable improved implementation and sustained use of RPM technology. This study seeks to enhance implementation and effectiveness of RPM among Latinx patients with uncontrolled HTN using CHWs supported by advanced RPM training and EHR support tools.

PI_NAMEs: MANN, DEVIN M (contact);SCHOENTHALER, ANTOINETTE M

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: access disparities;Address;Adoption;Adult;Blood Pressure;Blood Pressure Monitors;blood pressure reduction;Cardiovascular Diseases;Caring;catalyst;Child Care;clinical practice;Communities;Community Health Aides;Competence;Complex;Consensus;cost;Data;Data Analytics;Decision Making;design;Devices;digital;digital health;digital tool;Disparity;disparity reduction;Effectiveness;effectiveness evaluation;Electronic Health Record;empowerment;Environment;Equity;experience;Exposure to;Face;Goals;Health;health care disparity;health care settings;health determinants;Health Disparities Research;health disparity;health equity;health literacy;health management;Health Services Accessibility;Health system;Health Technology;Healthcare;Hypertension;hypertension control;implementation evaluation;implementation facilitation;implementation outcomes;implementation/effectiveness;Improve Access;improved;Individual;Inequity;Informatics;Infrastructure;insight;Intervention;Interview;Language;Latinx;member;Methods;Modeling;Neighborhood Health Center;new technology;novel;Office Visits;Outcome;Patient Care;patient navigator;patient population;Patients;Population;Population Heterogeneity;primary care team;primary outcome;Proctor framework;Provider;remote monitoring;remote patient monitoring;Research;Research Design;Resources;Risk;Services;social;social determinants;standard of care;structural health determinants;support tools;Surveys;System;technique development;Technology;technology validation;theories;tool;Training;Training Activity;Transportation;United States;user centered design;Work

PROJECT_TITLE: Partners IN CONTROL: Using Remote MonitorINg teChnology with cOmmuNity healTh woRkers to support hypertensiOn management for Latinx patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-W(02)M]


NIH_SPENDING_CATS: Arthritis;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Neurosciences;Pain Research

PI_NAMEs: MILLER, RACHEL ELIZABETH (contact)

PROJECT_TERMS: Address;Analgesics;Animal Model;Animals;Anxiety;Arthritis;Behavior;Behavior assessment;behavior measurement;behavior test;Behavioral;Behavioral Assay;Biological Assay;Chicago;Collaborations;Communities;Consultations;Degenerative polyarthritis;design;Development;Disease;disease model;Educational Activities;Educational Materials;Equipment;Evaluation;experience;Experimental Models;Female;Fostering;Geography;Goals;innovation;International;Laboratories;Leadership;male;Modeling;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal Pain;Needs Assessment;Neurobiology;new technology;novel;novel therapeutics;Outcome;Pain;pain behavior;Pathway interactions;Patients;Persons;Phenotype;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Proprioception;Protocols documentation;Qualifying;Research;Research Personnel;Research Support;Research Training;Resources;Rheumatism;Rheumatoid Arthritis;Rodent;Rodent Model;Services;Social Behavior;somatosensory;spontaneous pain;Surveys;synergism;Technical Expertise;Testing;testing services;Time;tool;Training;Training Activity;virtual;web portal

PROJECT_TITLE: Behavioral Core B


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetic Testing;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE  The goal of our proposal is to define the clinical relevance of variants associated with Leber congenital amaurosis (LCA) and early onset retinal degeneration (eoRD) by establishing a variant curation expert panel (VCEP) to develop disease-gene specified rules for curation, and to systematically classify variants, implementing the specified rules and ClinGen-approved protocols. The results will generate an FDA expert level approved resource of accurately classified variants in LCA/eoRD genes that will improve the consistency and accuracy of interpreting diagnostic genetic test results, leading to more precise diagnosis and improved medical care.

PI_NAMEs: DUNCAN, JACQUE LYNNE (contact)

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: Academia;Address;Advanced Development;Amblyopia;Authorization documentation;autosome;Benign;Bioinformatics;Blindness;Candidate Disease Gene;Caring;Certification;Cessation of life;Characteristics;Child;Childhood;Classification;Clinical;clinical care;clinical diagnosis;Clinical Trials;clinically actionable;clinically relevant;clinically significant;ClinVar;Data;data submission;Deposition;Development;Diagnosis;Diagnostic;Disease;disease-causing mutation;early onset;Eligibility Determination;experience;FDA approved;Funding Opportunities;Future;gene replacement therapy;Gene Targeting;gene therapy;Genes;Genetic;Genetic Counseling;genetic testing;genetic variant;Genome;genome resource;Goals;Grant;Guidelines;Hereditary Disease;improved;Industry;infancy;Inherited;International;Knowledge;Leadership;Leber's amaurosis;Medical;Mendelian disorder;Modification;molecular pathology;Mutation;Pathogenicity;Patient Care;Patients;personalized care;Phenotype;Photoreceptors;pilot test;preclinical study;prevent;Process;Protocols documentation;public database;Research;Resources;response;Retina;Retinal Degeneration;Retinal Diseases;RPE65 protein;Specific qualifier value;Test Result;tool;treatment trial;United States National Institutes of Health;Variant;Work;working group

PROJECT_TITLE: Expert curation of clinically significant variants in genes for early onset retinal degeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-B(50)R]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: Acute kidney injury (AKI) is estimated to affect 13 million people and results in 2 million deaths each year around the world. Currently there are no effective pharmacologic treatments to prevent AKI, improve outcomes of AKI, or suppress the transition from AKI to chronic kidney disease (CKD) and this is predominantly because of lack of knowledge regarding what happens in the human kidney when AKI occurs. We now propose to study human AKI and CKD biopsy tissues to understand the injury signals and cellular responses and to work collaboratively with KPMP consortium members to better understand AKI, thus identifying therapeutic targets for improving outcomes in patients with AKI and CKD.

PI_NAMEs: CANTLEY, LLOYD G;KAKADE, VIJAYAKUMAR RAGHURAMA RAO (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: 3-Dimensional;Ablation;Acute Renal Failure with Renal Papillary Necrosis;Affect;Altruism;analysis pipeline;Animal Model;Antibodies;antibody conjugate;Attention;Automobile Driving;Award;Binding;Biopsy;Biopsy Specimen;Cell Communication;Cell Count;cell injury;cell type;Cells;Cessation of life;Chronic Kidney Failure;Clinical;Compensation;Complex;computerized data processing;Coupled;Critical Illness;Cytometry;Data;Data Analyses;delayed graft function;dimensional analysis;Ensure;eosinophil;Etiology;Formalin;Freezing;Generations;glomerular filtration;Heavy Metals;high dimensionality;Homing;Human;Image;improved;improved outcome;Individual;Infiltration;Injury;injury and repair;Injury to Kidney;Intervention;Kidney;kidney biopsy;kidney cell;Kidney Diseases;kidney repair;Knowledge;Lasers;Location;Machine Learning;Maps;Mass Spectrum Analysis;mast cell;member;metabolomics;Molecular;Monoclonal Antibodies;mortality;neutrophil;novel;Nuclear;Nuclear RNA;Paraffin Embedding;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Performance;Persons;Pharmacological Treatment;Physiologic pulse;Population;precision medicine;preimplantation;preservation;prevent;Process;Proteomics;Protocols documentation;prototype;quality assurance;Quality Control;Rare Earth Metals;reconstruction;recruit;Reproducibility;Resolution;response;Risk;Running;Sampling;Signal Transduction;single cell sequencing;single nucleus RNA-sequencing;single-cell RNA sequencing;Spottings;Standardization;Syndrome;System;T-Lymphocyte Subsets;Techniques;Technology;therapeutic target;Time;Tissues;transcriptome sequencing;Tubular formation;tumor;vascular injury;Work

PROJECT_TITLE: Spatial Elucidation of Human Acute Kidney Injury and Chronic Kidney Disease using Imaging Mass Cytometry


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project narrative This proposal focuses on genetic and biochemical mechanisms misactivating the cell cycle in meningioma, the most common primary intracranial tumor. Our objectives are to define the efficacy and biomarkers of response to CDK6 inhibitors in meningioma, define the molecular mechanisms underlying CDK6 misactivation in meningiomas, and identify pathways mitigating resistance to CDK6 blockade in meningioma. By integrating human samples, an innovative organoid model of meningioma tumorigenesis, and understudied patient derived meningioma xenografts with CRISPR interference and pharmacology, this work will provide fundamental insights into meningioma biology and establish preclinical foundation to support new trials for meningioma patients.

PI_NAMEs: RALEIGH, DAVID R (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;African American;Automobile Driving;Binding;Biochemical;Biochemistry;Biology;Brain Neoplasms;California;CDK4 gene;Cell Cycle;Cell Cycle Inhibition;Cell Line;Cell Proliferation;Cells;Central Nervous System;Cerebrum;ChIP-seq;Clinical;Clinical Research;Clinical Trials;Coculture Techniques;cohort;Collaborations;Copy Number Polymorphism;CRISPR interference;CRISPR screen;Cyclin-Dependent Kinase Inhibitor 2A;Data;Developmental Therapeutics Program;Diagnosis;DNA Methylation;DNA methylation profiling;DNA Probes;Drug Kinetics;Enhancers;Epigenetic Process;experience;follow-up;Foundations;Future;Genetic;genome-wide;Goals;Growth;Hand;Histologic;Histology;Homeostasis;Hong Kong;Human;improved;In Vitro;inhibitor;innovation;insight;Intracranial Neoplasms;Investigation;Malignant Intracranial Neoplasm;Malignant Neoplasms;Meningeal;Meningeal Neoplasms;meningioma;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;Mus;Neurologic;neuron development;new therapeutic target;Normal tissue morphology;novel;novel therapeutics;older adult;Oncogenic;Organoids;Outcome;Pathway interactions;patient derived xenograft model;Patients;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacological Treatment;Pharmacology;pre-clinical;Pre-Clinical Model;preclinical study;predict clinical outcome;Predisposition;prevent;Process;promoter;Reagent;Recurrence;Research;Resistance;resistance mechanism;response biomarker;Sampling;San Francisco;Signal Transduction;Study models;Subgroup;success;targeted treatment;Testing;Therapeutic;Tissues;TP53 gene;transcription factor;transcriptome sequencing;treatment and outcome;tumor;tumor growth;Tumor Tissue;tumorigenesis;Universities;USF1 gene;Woman;Work;Xenograft procedure

PROJECT_TITLE: Understanding druggable drivers of meningioma tumorigenesis

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]