ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HUNTSVILLE

ORG_NAME: HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY

ORG_STATE: AL

PHR: Project Narrative Mutations in the ZEB2 gene cause an intellectual and developmental disability, Mowat-Wilson syndrome, which is characterized by developmental delays, intellectual disabilities, and various physical malformations. This work will identify the primary functions of the ZEB2 protein in human cells that are relevant to neural development and illuminate the impacts of gene changes found in children suffering from the disorder. The knowledge gained from the proposed work will inform future research, including diagnoses and potential therapeutic interventions.

PI_NAMEs: PARTRIDGE, EDWIN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: SHARMA, KARLIE ROXANNE

PROJECT_TERMS: Address;analytical method;Base Sequence;Binding;Binding Sites;Biological Assay;Biology;Brain;Cell Culture Techniques;Cell Differentiation Induction;Cell Differentiation process;Cell Line;cell type;Cells;Child;ChIP-seq;chromatin immunoprecipitation;Classification;Clinical;clinical diagnosis;clinically relevant;ClinVar;Code;cofactor;Craniofacial Abnormalities;CTBP1 gene;Data;Dependence;Development;Developmental Delay Disorders;Diagnosis;differential expression;Disability research;Disease;DNA Binding;Dose;Epitopes;experimental study;Foundations;Future;Gene Expression;Genes;genetic variant;genome-wide;genome-wide analysis;Genomics;High-Throughput Nucleotide Sequencing;Homeobox;Human;human induced pluripotent stem cells;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;insight;Intellectual functioning disability;interest;Intervention;Knowledge;Lead;malformation;Measures;Mendelian disorder;Methods;Motor;Mowat-Wilson syndrome;mutant;Mutation;Neomycin resistance gene;neurodevelopment;Neurons;Nonsense Codon;Nucleotides;Outcome;Pathogenicity;Patients;Phenotype;Positioning Attribute;premature;proband;Proteins;Protocols documentation;Publishing;Puromycin;rare variant;Regulatory Element;Research;Research Personnel;Resistance;Role;severe intellectual disability;Site;System;Therapeutic Intervention;Tissues;transcription factor;transcription termination;transcriptome sequencing;Validation;Variant;variant of unknown significance;Work;Zinc Fingers

PROJECT_TITLE: Functional characterization of clinically-identified coding variants in the transcription factor gene ZEB2

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-8 (01)]


ADMINISTERING_IC: HG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative Spatially resolved transcriptomics (ST), the Nature Methods 2020 Method of the Year, is poised to transform our understanding of how the spatial organization of cells in complex tissues influences function, disease initiation, progression, and therapeutic response. However, existing statistical methods to analyze these data fail to address new challenges, thereby limiting appropriate interpretation of these increasingly complex data. These urgently needed spatially-aware, unsupervised statistical methods and open-source software proposed in this award will enable ST technologies to transform precision medicine through novel biological insights relating to spatial properties of cell populations and gene expression in healthy and diseased tissues.

PI_NAMEs: WEBER, LUKAS MARTIN (contact)

PROGRAM_OFFICER_NAME: DI FRANCESCO, VALENTINA

PROJECT_TERMS: Address;Adopted;Award;Awareness;Benchmarking;Biological;career;cell type;Cells;Classification;Communities;Complex;complex data;Computer software;Data;Data Analyses;data infrastructure;data resource;Data Set;data standards;Data Storage and Retrieval;density;design;Development;Diagnosis;Dimensions;Disease;Evaluation;Expression Profiling;Extramural Activities;Faculty;feature selection;Funding;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic Markers;Genetic Transcription;Goals;Health;Heterogeneity;Human;improved;Individual;insight;Institution;Knowledge;Machine Learning;Measurement;Measures;Mentors;Methodology;Methods;Molecular;Nature;novel;open source;Outcome;Pathway interactions;Pattern;Phase;Population;Positioning Attribute;precision medicine;preservation;Procedures;Prognosis;Property;Quality Control;Research;Research Personnel;Resolution;Resources;RNA;Signal Transduction;single-cell RNA sequencing;Specificity;Spottings;Standardization;Statistical Methods;statistics;Systematic Bias;Techniques;Technology;tenure track;Time;Tissue Microarray;Tissues;tool;Training;Transcript;transcriptome;transcriptomic profiling;transcriptomics;treatment response;two-dimensional;unsupervised clustering;Variant;Weight;Work

PROJECT_TITLE: Unsupervised Statistical Methods for Data-driven Analyses in Spatially Resolved Transcriptomics Data

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Microbiome;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative / Public Health Relevance Statement Our proposed studies will yield essential insights into early diagnostic biomarkers for ovarian cancer. This work will have important implications for early detection, which will have a direct impact on the precision prevention landscape for ovarian cancer. In addition, our studies will shed light on fundamental parameters that drive significantly lower survival rates for black women.

PI_NAMEs: DUNCAN, MELINDA K (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: 5 year old;accurate diagnostics;Age;Age of Onset;Animal Model;Animals;Award;Bacteria;Bacteriophages;Benign;Biological Markers;biomarker identification;black women;Blood;Cancer Etiology;cancer initiation;Cancer Patient;Cancer Research Project;Cessation of life;Chickens;Clinical;Clinical Research;cohort;Community Outreach;computerized tools;Data;Delaware;Department of Defense;design;Detection;detection method;diagnostic biomarker;Diagnostic tests;Disease;Disease Progression;Drops;Early Diagnosis;Early identification;Event;Female;fighting;Foundations;fungus;Future;germ free condition;Goals;Growth;Gynecologic;Harvest;Human;improved;individualized prevention;insight;Investigator-Initiated Research;Ions;Lipids;Liquid Chromatography;longitudinal analysis;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Mammography;Menopause;metabolomics;microbial;microbiome analysis;microbiome composition;microbiota;Modeling;multiple reaction monitoring;Mus;Ovarian;Ovary;Ovulation;Pap smear;Patients;Penetrance;Pilot Projects;Plasma;pre-clinical;precision cancer prevention;Predisposition;public health relevance;Reporting;reproductive tract;Research;Resources;Risk Factors;Role;Sampling;Screening for Ovarian Cancer;Staging;Survival Rate;tandem mass spectrometry;Testing;Time;tumor progression;United States National Institutes of Health;Validation;Virus;Woman;Work

PROJECT_TITLE: Delaware INBRE


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Mental Health;Mental Illness;Neurosciences;Substance Misuse

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Alcohol use disorders (AUD) and panic disorder (PD) are highly comorbid and debilitating mental health disorders that may co-occur because of shared underlying mechanisms, such as dysregulated acid-sensing. The goal of this project is to investigate the role of an acid-sensing mechanism in AUD-associated outcomes and determine if dysregulated acid-sensing contributes to development of comorbid PD following alcohol dependence. This study will improve our understanding of acid-sensing in AUDs and the development of comorbid outcomes, and identify novel therapeutic targets to better treat or prevent AUD and PD.

PI_NAMEs: MCMURRAY, KATHERINE MILES JOHNSTON (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Abstinence;Acid-Base Imbalance;Acidosis;Acids;Acute;Alcohol abuse;alcohol comorbidity;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol use disorder;Alcohol withdrawal syndrome;Anxiety;Attenuated;awake;base;Behavior;Behavioral;binge drinking;Blood - brain barrier anatomy;Blood Pressure;Brain;Carbon Dioxide;cardiovascular effects;Cardiovascular Physiology;Cardiovascular system;career;Cell Death;chronic alcohol ingestion;Collection;comorbidity;Complex;Darkness;Data;Dependence;deter alcohol use;Development;Disease;drinking;Emotional;Emotions;Ethanol;Foundations;Fright;Functional disorder;Genes;Genetic;Goals;Heart Rate;heart rate variability;Homeostasis;Hyperventilation;improved;Individual;Inhalation;knock-down;Lesion;Mediating;Mental disorders;Methods;Modeling;Molecular;mouse model;Mus;neural circuit;Neuroimmune;Neuroimmunomodulation;neuroinflammation;new therapeutic target;novel;Outcome;Panic;Panic Attack;Panic Disorder;Pathology;Patient-Focused Outcomes;Patients;Phase;Physiological;Physiology;Plethysmography;Positioning Attribute;Predisposition;promoter;psychiatric comorbidity;Publishing;Research;resilience;Respiration;respiratory;response;Rodent;Role;sensor;Severities;Signal Transduction;Stress;Subfornical Organ;T cell regulation;T-Lymphocyte;Telemetry;Testing;Time;Training;Treatment outcome;Up-Regulation;Viral;Withdrawal

PROJECT_TITLE: Acid sensing associated mechanisms in AUD and comorbid panic


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Disability Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Psychosis;Rehabilitation;Serious Mental Illness

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Individuals living with serious psychiatric disorders often experience significant social-cognitive dysfunction secondary to mental illness, yet these impairments are not amenable to psychiatric medications and psychosocial interventions for social impairments are often difficult to access or otherwise limited in their scope or clinical benefit. Though social-cognitive impairment has known neural bases and is a recognized area of clinical relevance and unmet need, emerging evidence suggests that the cerebellum has a critical role in social- cognitive function that has largely been overlooked in the study of mental illness. The proposed study will examine a brain network model unifying dynamic interactions between cerebral and cerebellum brain regions involved in social cognition and the association of neural function to key outcomes in a transdiagnostic sample of individuals with mental illness, which has important translational implications for the refined identification of treatment targets most strongly associated with difficult-to-treat social dysfunction.

PI_NAMEs: MOE, AUBREY M. (contact)

PROGRAM_OFFICER_NAME: BROWN, PATRICK

PROJECT_TERMS: Address;Adolescent and Young Adult;Adult;Affect;age group;Anxiety;Architecture;Area;autism spectrum disorder;base;Belief;Brain;Brain region;Categories;Cerebellum;Cerebrum;Chronic Disease;Clinical;clinically relevant;Cognitive;cognitive function;cognitive performance;cognitive task;Data;Data Set;Diagnostic;Dimensions;Disease;Effectiveness;experience;Functional impairment;Functional Magnetic Resonance Imaging;functional outcomes;Future;Impaired cognition;Impairment;improved;Independent Living;Individual;Interpersonal Relations;Intervention;Investigation;Life;Link;Measures;Medial;Mental disorders;Mental Processes;mental state;mentalization;Mentors;Modeling;network models;neural;neurobiological mechanism;Neurobiology;Neurophysiology - biologic function;neuroregulation;noninvasive brain stimulation;novel;novel therapeutics;Occupational;Onset of illness;Outcome;outcome prediction;Persons;Pharmaceutical Preparations;Phase;Phenotype;Play;Population;Prefrontal Cortex;Psychoses;psychosocial;Psychotic Disorders;Research;Role;Sampling;Scalp structure;Secondary to;severe mental illness;social;social anxiety;Social Anxiety Disorder;Social Behavior;social cognition;social deficits;Social disability;Social Functioning;social interventions;Social outcome;Social Perception;translational clinical trial;translational neuroscience;translational study;young adult;Youth

PROJECT_TITLE: Elucidating Cerebellar Contributions to Social Cognition: A Transdiagnostic Investigation

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-4 (01)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services

ORG_CITY: PROVIDENCE

ORG_DEPT: PEDIATRICS

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE – OVERALL The Universities, Hospitals and Community Organizations in Rhode Island are well positioned to bridge the gaps between the worlds of clinical and basic science. Using the targeted resources of an IDeA-CTR Award, the Brown Institute for Translational Sciences, and a statewide consortium of collaborators, hospitals, universities, non-profit organizations and government agencies, will draw on the resources already developed in the NIH Institutional Development Award (IDeA) programs (core labs and faculty development programs) to enhance the Advance Clinical and Translational Research Program’s (Advance-CTR) ability to support clinical and translational research. We will serve as a bench-to-bedside research network and career development umbrella for the investigator community in affiliated institutions. In so doing, we will enhance patient-centered research and accelerate discoveries and health innovations to benefit our communities and to serve our State.

PI_NAMEs: ROUNDS, SHARON IRENE SMITH (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Acceleration;Address;Area;Award;Basic Science;bench to bedside;Big Data;Biological;biomedical informatics;Biometry;career;career development;Caring;Clinical;clinical application;Clinical effectiveness;clinical infrastructure;clinical practice;Clinical Research;Clinical Sciences;clinical translation;Collaborations;Communities;community engaged research;community engagement;Community Mental Health Services;community organizations;Community Outreach;Core Facility;cost;COVID-19;Data;demographics;Development;Discipline of Nursing;Education;Environment;Epidemiology;Evolution;Extramural Activities;Fostering;Funding;Funding Opportunities;Future;Goals;Government Agencies;Grant;Health;health care delivery;health disparity;health equity;Health Policy;Health Priorities;Health Services;Health system;Healthcare Systems;Home;hospital organization;Hospitals;Human Resources;improved;Infrastructure;innovation;Institution;laboratory development;life span;Mentors;Modeling;multidisciplinary;National Institute of General Medical Sciences;New England;Nonprofit Organizations;organizational structure;Outcome;patient oriented;Pharmacy facility;Pilot Projects;Population;Positioning Attribute;prevent;Productivity;Program Development;Program Evaluation;programs;Protocols documentation;Public Health;Publications;Research;Research Design;Research Infrastructure;Research Personnel;Research Proposals;Research Support;Resources;Rhode Island;Services;success;synergism;Teacher Professional Development;Testing;Training;Translating;Translational Research;translational research program;translational scientist;United States National Institutes of Health;Universities;virtual;Vulnerable Populations

PROJECT_TITLE: Advance Clinical and Translational Research (Advance-CTR)


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Although financial hardship (including financial stress, financial strain, asset depletion, and financial toxicity) is highly relevant for families of people living with Alzheimer's disease and Alzheimer's disease related dementias (ADRD), public health efforts to support these families are lacking. One reason for this shortcoming is that there is no systematic way to assess financial hardship for families affected by ADRD, precluding our ability to characterize the problem and identify families at risk for poor outcomes. To address this gap, we propose developing a new measurement system that can capture the multi-faceted aspects of financial hardship experienced by these families and be used to identify families at high risk for poor financial-related outcomes.

PI_NAMEs: CARLOZZI, NOELLE E. (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease related dementia;Anxiety;Astronomy;Calibration;care costs;care recipients;care systems;career;Caregivers;caregiving;Caring;Case Report Form;Clinical;Computers;cost;Data Analyses;Dementia;Development;Economic Burden;Economics;Elements;Eligibility Determination;ethnic minority;Evaluation;evidence base;experience;Family;Family Characteristics;Family member;family support;field study;Financial Hardship;Financial Support;financial toxicity;Health;health care availability;health care disparity;Health Personnel;health related quality of life;Health Services Accessibility;high risk;Household;improved;intergenerational;Interview;Life;life time cost;Literature;Long-Term Care;Long-Term Care Insurance;loved ones;Measurement;Measures;member;Mental Health Services;Methods;Modeling;National Institute on Aging;Outcome;Participant;patient home care;Patient Outcomes Assessments;Patient Self-Report;Patients;payment;Personal Satisfaction;Persons;physical conditioning;Policies;poor health outcome;programs;psychological distress;Public Health;Public Housing;racial minority;Request for Applications;Research;Research Personnel;response;Risk;Savings;screening;Services;Social Security;Statistical Data Interpretation;Structure;Supportive assistance;Supportive care;Surveys;System;system-level barriers;Testing;theories;Time;Uninsured Medical Expense;Wages;Work

PROJECT_TITLE: Financial stress, financial strain, asset depletion, and financial toxicity: New measures to characterize the financial impact that dementia has on families

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-5 (M1)]


ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Narrative: This is not required per the FOA as the application is not a competing administrative supplement.

PI_NAMEs: KARAGAS, MARGARET RITA (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Administrative Supplement;Affect;Age;Automobile Driving;Biological;Biological Markers;Biopsy;Blood;Cell Differentiation process;cell type;Cells;chronic pelvic pain;Clinical;clinically relevant;Cytometry;Data;Deposition;Development;Diagnosis;diagnostic biomarker;diagnostic development;Disease;DNA;DNA Methylation;Endometrial;endometriosis;Endometrium;Epigenetic Process;epigenome-wide association studies;Estrogens;Future;Genes;Global Change;Goals;Heterogeneity;Image;Immune;Immune System Diseases;improved;Infertility;Inflammation;Laparoscopic Surgical Procedures;Lesion;Measures;Methods;Methylation;methylation pattern;Modeling;Modification;Molecular Analysis;Molecular Epidemiology;molecular marker;novel;Operative Surgical Procedures;Pain;Pathogenesis;Patients;Pelvic Examination;Phase;Physicians;Procedures;prospective;Quality of life;Research;response;Role;Specific qualifier value;Specimen;Symptoms;Tissue Sample;Tissues;tumor;United States;Uterine cavity;Validation;Woman;Work

PROJECT_TITLE: Center for Molecular Epidemiology


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LEXINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE  Wnt signaling is a rapidly evolving and important field of investigation and new regulators involved in this cascade are continuously being identified. Our study focuses on developing a mechanistic understanding of PTPRF-mediated regulation of Wnt signaling and intestinal stem cell function. Results from our studies will help identify new therapeutic strategies for treating Wnt-driven diseases by using PTPRF as a target.

PI_NAMEs: GAO, TIANYAN  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: 3-Dimensional;Attention;Attenuated;Automobile Driving;Basic Science;beta catenin;Bioinformatics;Biological Process;cancer cell;Caveolins;Cell Differentiation process;Cell membrane;Cell Proliferation;Cells;Cellular biology;Colon;colon cancer patients;Colon Carcinoma;colon tumorigenesis;Colorectal Cancer;Complex;CRISPR/Cas technology;Data;Development;Disease;Endocytosis;Ensure;Epithelium;Equilibrium;Genes;Goals;Human;Human body;In Vitro;in vivo;inhibitor;insight;Internal Ribosome Entry Site;intestinal crypt;intestinal epithelium;intestinal homeostasis;Intestines;Investigation;knock-down;Knock-out;Knockout Mice;Knowledge;LGR5 gene;Maintenance;Mediating;Modeling;Molecular;mouse model;Mus;Mutation;novel;novel therapeutic intervention;Oncogenic;Organism;Organoids;Pathway interactions;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;Physiology;Play;Process;Proliferating;Protein Dephosphorylation;Protein Kinase;Protein phosphatase;Protein Tyrosine Phosphatase;Proteins;PTPRR gene;receptor;Regulation;Reporter;Role;Sampling;self-renewal;Signal Transduction;single-cell RNA sequencing;stem cell fate;stem cell function;stem cell proliferation;stem cells;stemness;success;System;targeted treatment;Technology;Testing;Tissues;Training;tumor growth;ubiquitin-protein ligase;Ubiquitination;Villus;WNT Signaling Pathway

PROJECT_TITLE: Diversity Supplement for Haley Stanczyk

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PI_NAMEs: ALTIERI, DARIO C (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TITLE: Consolidated Basic Cancer Research Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PI_NAMEs: SPEICHER, DAVID W. (contact)

PROJECT_TERMS: Acetates;Address;Award;Basic Cancer Research;Biological;Biological Assay;Budgets;Cancer Biology;cancer cell;Cancer cell line;Cancer Center;Cancer Research Project;Complex;Consultations;cost;cost effective;Dedications;Detection;Development;Electrospray Ionization;Energy-Generating Resources;Ensure;experimental study;fatty acid oxidation;Fatty Acids;Fox Chase Cancer Center;Fractionation;Funding;Future;Gel;Genes;Genus Hippocampus;Glucose;Glutamine;Goals;Grant;High Pressure Liquid Chromatography;Human;Hybrids;improved;innovation;Institution;instrument;instrumentation;interest;Ions;Isotopes;Label;lipidomics;Lipids;Liquid substance;mass spectrometer;Mass Spectrum Analysis;Measurement;member;Metabolic;metabolic phenotype;metabolomics;Methods;Mitochondria;nano;NCI-Designated Cancer Center;oxidation;Pathway interactions;Performance;Post-Translational Protein Processing;Protein Analysis;Proteins;Proteome;Proteomics;Reagent;Research Personnel;Resolution;Resource Sharing;Respiration;Running;S10 grant;Sampling;Secondary to;Serum;Services;Speed;stable isotope;Stable Isotope Labeling;System;Technology;Tissues;Tracer;tumor metabolism;Tumor Tissue;ultra high pressure;Universities

PROJECT_TITLE: Proteomics and Metabolomics Shared Resource


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PI_NAMEs: VICKERS, SELWYN M (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TITLE: Cancer Center Support Grant


NIH_SPENDING_CATS: Cancer

PI_NAMEs: LIPMAN, NEIL SCOTT (contact)

PROJECT_TERMS: Accreditation;Anatomy;animal care;Animal Experimentation;Animal Model;animal resource;Animals;anti-cancer research;Area;Biological;biosecurity;Cancer Center Support Grant;cancer therapy;Caring;Clinical;clinical care;comparative;Comparative Pathology;Comprehensive Health Care;Development;Diagnosis;Education;Ensure;Environment;Equipment;Ethics;Genetic Engineering;Health;Housing;Individual;Infrastructure;Laboratories;Laboratory Research;learning materials;Maintenance;Medicine;Methods;Mission;Monitor;multidisciplinary;Neoplasms;Online Systems;operation;pathogen;Pathology;Phenotype;Procedures;programs;quality assurance;Quarantine;Research;Research Personnel;Resources;Rodent;Services;square foot;Surveys;System;Training;Training and Education;Vendor;Writing;Zebrafish

PROJECT_TITLE: Center of Comparative Medicine and Pathology


PI_NAMEs: GARDNER, RUI  (contact)

PROJECT_TERMS: Address;Allogenic;anti-cancer research;Calibration;Cancer Center;Cancer Center Support Grant;cancer diagnosis;cancer therapy;CD19 gene;cell analyzer;Cell Separation;Cells;chimeric antigen receptor T cells;Complex;Computer software;Computers and Advanced Instrumentation;Contract Services;CRISPR/Cas technology;Data;Data Analyses;Development;Dimensions;DNA sequencing;Education;Ensure;experience;experimental study;Exposure to;Flow Cytometry;genome editing;Genomics;Goals;Grant;high throughput screening;Immunophenotyping;improved;In Vitro;insight;instrument;instrumentation;Intervention;Journals;Knowledge;Label;Laboratories;Licensing;Lymphoma;Maintenance;meetings;member;Methods;Modernization;Monitor;Mus;new technology;novel;Performance;Police;Population;Preparation;Process;programs;Publications;Qualifying;Quality Control;repaired;Reproducibility;Research;research and development;Research Personnel;Resources;RNA;Role;Sampling;Schedule;Science;Scientist;Services;Signal Transduction Pathway;Site;Sorting;Speed;System;T-Lymphocyte;Techniques;Technology;Testing;Training;Training and Education;transcriptomic profiling;transcriptomics;Transplantation;tumor;Tumor-Associated Process

PROJECT_TITLE: Flow Cytometry


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome

PI_NAMEs: NANJANGUD, GOURI  (contact)

PROJECT_TERMS: Aneuploidy;Animal Model;Bacterial Artificial Chromosomes;Biological Assay;biological specimen archives;blastocyst;Cancer Center Support Grant;Categories;Cell Line;Cells;Cellular Structures;Chromosomal Instability;Chromosome abnormality;Chromosome Mapping;Chromosome Painting;Chromosomes;Color;cost;Custom;Data Analyses;design;Development;DNA;Exhibits;Experimental Designs;fluorescence imaging;Fluorescent in Situ Hybridization;Genomics;Grant;Heterogeneity;human model;imaging system;Individual;Injections;integration site;Karyotype determination procedure;Malignant Neoplasms;Manuscripts;Measures;Modernization;Molecular Cytogenetics;Monitor;Mus;neoplastic cell;Normal Cell;patient oriented;Plasmids;Preparation;programs;Proteins;Research;Research Personnel;Research Support;Resources;Role;Sampling;Services;Spectral Karyotyping;stem cells;Testing;Time;tissue culture;Training;Transgenes;tumor heterogeneity;Work

PROJECT_TITLE: Molecular Cytogenetics


PI_NAMEs: MANOVA, KATIA OGNIANOVA (contact)

PROJECT_TERMS: Animals;Antibodies;Area;Behavior;Binding;Biological Markers;Cancer Center;Cancer Center Support Grant;Cancer Patient;Cells;Collaborations;confocal imaging;Cytology;Data;Data Analyses;Detection;digital;Disease;Embryo;Ensure;experimental study;Fluorescence;Glycoproteins;Histology;Image;Image Analysis;image processing;imaging capabilities;Imaging Device;imaging modality;Immunofluorescence Immunologic;Immunohistochemistry;In Situ;inhibitor;investigator training;Lipids;Malignant Neoplasms;Manuals;member;Methodology;Microscopy;Mission;Molecular;molecular marker;multiplex detection;Mus;nanomaterials;nanometer resolution;Normal tissue morphology;Nucleic Acids;optical imaging;Organoids;Pathologic;Pathologic Processes;Pathway interactions;Pharmaceutical Preparations;Preparation;Process;Proteins;Protocols documentation;Reproducibility of Results;Research;Research Personnel;Research Project Grants;Research Support;Resources;Sampling;Scanning;Scanning Probe Microscopes;Services;Slide;spectroscopic imaging;Stains;superresolution imaging;Technology;Thick;Three-Dimensional Image;Tissue imaging;tissue preparation;Tissue Sample;Tissues;Training;tumor;Validation;Visualization

PROJECT_TITLE: Molecular Cytology


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: WEIS-GARCIA, FRANCES  (contact)

PROJECT_TERMS: Acholeplasma;Address;Antibodies;Basic Science;Binding;Biological;Cancer Center;Cancer Center Support Grant;cancer therapy;Cell Culture Techniques;Cell Line;cellular imaging;Characteristics;Clinical Research;Communities;cost effective;Data;Deposition;Diagnosis;Ensure;Entomoplasma;fluorophore;Grant;Human Cell Line;Hybridomas;In Vitro;interest;Karyotype determination procedure;Marketing;Mollicutes;Monoclonal Antibodies;Mycoplasma;programs;Proteins;Publications;Reagent;Recording of previous events;Reproducibility;Research;Research Personnel;Scientist;Services;Spiroplasma;System;Techniques;Test Result;Testing;testing services;Time;tool;translational goal;Translational Research;Work

PROJECT_TITLE: Antibody and Bioresource


PI_NAMEs: GOLDGUR, YEHUDA  (contact)

PROJECT_TERMS: 3-Dimensional;Address;beamline;Biological Process;Cancer Center Support Grant;Collaborations;Computer software;computerized data processing;computing resources;Cryoelectron Microscopy;Crystallization;Data;Data Collection;data structure;design;detector;drug discovery;Electron Microscope;Electron Microscopy Facility;Equipment;experimental study;Goals;Head;insight;Institution;Investigation;Laboratories;Linux;Modeling;Performance;Preparation;programs;Proteins;Publications;Research;Research Personnel;Resource Sharing;Resources;Roentgen Rays;Sampling;Services;structural biology;Structure;Synchrotrons;Technology;Titan;Training;tumorigenesis;X-Ray Crystallography

PROJECT_TITLE: Structural Biology


PI_NAMEs: LEKAYE, HONGBIAO CARL (contact)

PROJECT_TERMS: animal imaging;Animals;Autoradiography;Biological;Bioluminescence;biosecurity;cancer cell;Cancer Center Support Grant;Clinical;Computer software;computerized data processing;Consultations;cost effectiveness;data management;digital;Disseminated Malignant Neoplasm;Dose;Equipment;equipment acquisition;Experimental Designs;Film;Floor;Fluorescence;fluorescence microscope;Fluorescent Probes;Funding;Genetic;Goals;Grant;human model;Image;image guided;image reconstruction;imaging modality;imaging study;imaging system;Imaging Techniques;in vivo;in vivo imaging system;Individual;instrumentation;irradiation;Laboratory Research;Longitudinal Studies;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Malignant Neoplasms;Metabolic;microCT;microPET;Microtome - medical device;Modeling;Monitor;Motor;multimodality;neoplastic cell;NMR Spectroscopy;Non-Invasive Detection;non-invasive imaging;optical imaging;Optics;parametric imaging;Peer Review;Phenotype;Positron-Emission Tomography;Publications;quantitative imaging;Radiation therapy;Radioisotopes;Radiolabeled;Radiometry;Reporter Genes;Research Personnel;Resolution;Rodent;Rodent Model;Services;single photon emission computed tomography;spectroscopic imaging;Structure;System;Therapeutic;Tracer;trafficking;Training;tumor;Ultrasonography;ultrasound;United States National Institutes of Health;Update;X-Ray Computed Tomography

PROJECT_TITLE: Animal Imaging


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PI_NAMEs: DRAETTA, GIULIO FRANCESCO (contact)


PI_NAMEs: KANODIA, SHREYA  (contact)

PROJECT_TERMS: Acceleration;Administrative Efficiency;Administrative Supplement;Applications Grants;Area;Biography;Businesses;Cancer Center;Cancer Center Support Grant;Cancer Patient;Capital;career;career development;Clinic;Clinical Data;Clinical Protocols;Collaborations;Communication;community engagement;Community Outreach;Core Facility;cost effective;data management;Data Reporting;Data Storage and Retrieval;Databases;Decision Making;Development;Equipment;Evaluation;Fostering;Funding;Funding Mechanisms;Grant;Institution;Interdisciplinary Study;Laboratories;Leadership;Maintenance;meetings;member;Mission;Monitor;Moon;Occupational activity of managing finances;operation;Pilot Projects;Preparation;Process;programs;Progress Reports;Protocols documentation;Publications;Reporting;Research;Research Personnel;Research Support;Resource Sharing;Resources;Science;Services;Strategic Planning;System;Translational Research;Writing

PROJECT_TITLE: Cancer Center Administration


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer

PI_NAMEs: DE STANCHINA, ELISA  (contact)

PROJECT_TERMS: Address;Advisory Services;Allografting;animal imaging;Animals;anti-tumor agent;Applications Grants;Biological Assay;Biopsy Specimen;Blood specimen;Cancer Center;Cancer Center Support Grant;Cancer Model;Cell Line;co-clinical trial;Collection;Communities;comparative;Core Facility;cost effective;cost efficient;Cytology;Data;design;Development;Disease;Dose;Drug Combinations;Drug Formulations;Drug Kinetics;efficacy study;Evaluation;experimental study;first-in-human;Formulation;Genomics;Goals;good laboratory practice;Hospitals;Human;imaging probe;in vivo;in vivo evaluation;in vivo imaging;Individual;interest;Investigational Drugs;Investigational New Drug Application;Logistics;Medicine;member;Modeling;Molecular;molecular imaging;mouse model;Mus;novel;novel therapeutics;Operative Surgical Procedures;Organ;Organic Synthesis;Pathology;patient derived xenograft model;Patients;personalized approach;Pharmacology and Toxicology;pre-clinical;preclinical development;preclinical efficacy;preclinical study;Preparation;Procedures;Protocols documentation;Publications;Radiochemistry;Reporting;repository;Reproducibility;Research Personnel;Resources;Rodent;Route;Running;Safety;Sampling;Services;subcutaneous;Technical Expertise;Therapeutic;Time;Tissue Procurements;Tissues;Toxic effect;Toxicology;translational goal;Translational Research;Treatment Protocols;tumor;Tumor Cell Line;Tumor Subtype;Work;Writing;Xenograft procedure

PROJECT_TITLE: Antitumor Assessment


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: RIVIERE, ISABELLE  (contact)

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Immunotherapy;Biological Products;Bioreactors;Biotechnology;Blood;Blood Component Removal;Bone Marrow;Cancer Center Support Grant;CD3 Antigens;CD34 gene;CD8B1 gene;cell bank;Cell Line;cell stroma;Cell Therapy;Cells;cellular engineering;cellular transduction;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Research;Clinical Trials;Clone Cells;Collaborations;Correlative Study;CRISPR/Cas technology;Cryopreservation;Cytotoxic Chemotherapy;Detection;Development;Endotoxins;Engineering;Enrollment;Ensure;Evaluation;Flow Cytometry;Formulation;Gene Transfer;Generations;Genes;Genomic DNA;Good Manufacturing Process;Hela Cells;Hematopoietic stem cells;Infusion procedures;integration site;Investments;Lymphocyte;manufacture;Memory;microbial;Mission;molecular targeted therapies;Mycoplasma;novel strategies;nuclease;Patient Monitoring;Patients;Peripheral Blood Mononuclear Cell;Phase;Phase I/II Clinical Trial;Phenotype;plasmid DNA;Process;Production;Protocols documentation;Quality Control;Reagent;Records;repository;Research Personnel;Retroviral Vector;Retroviridae;Safety;Sampling;Site;Somatic Cell;Southern Blotting;Specimen;stem cell therapy;System;Technology;Testing;Time;tissue culture;Titrations;Training;transgene expression;Umbilical cord structure;United States National Institutes of Health;Vaccines;Validation;vector;vector transmission;Work

PROJECT_TITLE: Gene Transfer and Somatic Cell Enginerring


PI_NAMEs: HUFF, VICKI  (contact)

PROJECT_TERMS: Award;Budgets;Cancer Center;Cancer Center Support Grant;Cells;ChIP-seq;Chromium;Clustered Regularly Interspaced Short Palindromic Repeats;computerized data processing;Core Facility;Data;Detection;Development;differential expression;digital;DNA Resequencing;Equipment;exome;Fees;Funding;Gene Expression;Gene Fusion;Generations;Genes;genome sequencing;genomic data;Genomics;Genotype;Grant;imaging system;Immune;innovation;Institution;instrumentation;interest;Journals;Measures;member;Methylation;MicroRNAs;Mission;nano-string;new technology;next generation sequencing;Peer Review;Phase;Plasma;Price;Procedures;Process;programs;Protocols documentation;Publications;Publishing;Reporting;Research Personnel;Research Support;Robotics;Sampling;Science;Serum;Services;single cell analysis;single cell ATAC-seq;Single Nucleotide Polymorphism;Somatic Mutation;Specimen;System;Systems Analysis;Technical Expertise;Technology;Time;Tissue Banks;Tissues;transcriptome sequencing;United States National Institutes of Health;Urine;Variant;whole genome

PROJECT_TITLE: 01 Sequencing and Microarray Facility


PI_NAMEs: ROEHRL, MICHAEL H. A. (contact)

PROJECT_TERMS: anti-cancer research;Antibodies;Basic Cancer Research;biobank;Biological;Blood specimen;Cancer Center Support Grant;cancer therapy;Cells;Clinical;Collection;cost effective;Data;design;Detection;detection platform;DNA;experimental study;Formalin;Freezing;Funding;Histologic;Histology;Human;Human Resources;human tissue;Immunohistochemistry;Institution;interest;Journals;Laboratories;laser capture microdissection;Liquid substance;Malignant Neoplasms;Manuals;Molecular;Monoclonal Antibodies;neoplastic;neoplastic cell;new technology;Paper;Paraffin Embedding;Pathology;polyclonal antibody;Population;Prevention;Procedures;Process;programs;Proteins;proteogenomics;Protocols documentation;Publications;Publishing;Research;Research Personnel;research study;Resources;RNA;Sampling;Services;Source;Specimen;Stains;technology platform;The Cancer Genome Atlas;Tissue Embedding;Tissue Microarray;tissue resource;Tissues;translational cancer research;tumor;Work

PROJECT_TITLE: Pathology


PI_NAMEs: JENSEN, VANESSA  (contact)

PROJECT_TERMS: Accreditation;Affect;animal care;Animal Experimentation;animal facility;Animal Husbandry;animal resource;Animals;Area;Automation;Award;Behavioral;Biological;Budgets;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer genetics;Canis familiaris;Caring;Cell Line;Censuses;Chemicals;Collaborations;computerized;Consultations;Containment;data integrity;design;Education;Environment;Epigenetic Process;Equipment;facility renovation;Faculty;Family suidae;Fishes;Funding;Genetic;Genetic Services;Gnotobiotic;Grant;hazard;Health;Histology;Housing;Image;Imaging Techniques;Infrastructure;Institution;International;Journals;Laboratories;Laboratory Animal Production and Facilities;Laboratory Animals;Location;Malignant neoplasm of gastrointestinal tract;Manuscripts;member;Metabolism;Mission;Modeling;Neoplasm Metastasis;operation;Operative Surgical Procedures;Oryctolagus cuniculus;Pathology;Peer Review;Personal Satisfaction;Preclinical Drug Development;Primates;Procedures;programs;quality assurance;Quarantine;Radioisotopes;Reproducibility;Research;research study;Rodent;Rodent Model;Science;Services;smart technologies;System;Techniques;Texas;Therapeutic Studies;Training;Veterinary Pathology

PROJECT_TITLE: 02 Research Animal Support Facility-Houston/Smithville


NIH_SPENDING_CATS: Cancer;Prevention

PI_NAMEs: OUERFELLI, OUATHEK  (contact)

PROJECT_TERMS: Biology;Cancer Center Support Grant;Cancer Detection;chemical synthesis;Chemicals;Chemistry;Communities;Consultations;Custom;Development;Experimental Designs;Formulation;Human Resources;Lead;lead candidate;manufacture;Medicine;member;Methods;Mission;novel;Organic Synthesis;Pharmaceutical Chemistry;Phase I Clinical Trials;preclinical study;Prevention;Procedures;Research Personnel;Services;Therapeutic Agents;tool;Work;Writing

PROJECT_TITLE: Organic Synthesis


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: BENAVIDES, FERNANDO J (contact)

PROJECT_TERMS: Address;American;animal care;animal facility;Animal Model;animal resource;Animals;anti-cancer research;Archives;Area;Award;blastocyst;Breeding;Budgets;Cancer Center;Cancer Center Support Grant;Capital Financing;Caring;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Compensation;conditional mutant;Consultations;cost;CRISPR/Cas technology;Cryopreservation;Derivation procedure;Detection;Development;DNA;E-learning;Educational process of instructing;Educational workshop;Electroporation;Embryo;embryonic stem cell;Equipment;ES Cell Line;experimental study;Faculty;Fertilization in Vitro;Funding;Gene Modified;Gene Targeting;Gene Transfer Techniques;Generations;Genes;Genetic;Genetic Engineering;Genetic Transcription;Genetically Engineered Mouse;Grant;Hormones;Human Resources;In Vitro;in vivo;Injections;innovation;Institution;Investments;Japan;Journals;Knock-in;Knock-out;Knowledge;Laboratory Animal Science;LacZ Genes;Libraries;Link;Mediating;member;Methodology;Microscope;Mission;Modeling;Mouse Embryonic Stem Cells;mouse genetics;mouse model;Mus;Mutation;new technology;Oocytes;Paper;Peer Review;Phenotype;plasmid DNA;Procedures;programs;Protocols documentation;Publications;Publishing;Reagent;Reproducibility;Research;Research Personnel;Resources;Science;Services;sperm cell;Stem Cell Development;Superovulation;System;Techniques;Testing;Texas;TP53 gene;Training;Transgenic Mice;Transgenic Model;Transgenic Organisms;tumor;Update;webinar

PROJECT_TITLE: 03 Genetically Engineered Mouse Facility


PI_NAMEs: LEWIS, JASON S. (contact)

PROJECT_TERMS: Animals;Antibodies;Antibody Formation;Basic Science;Biodistribution;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer imaging;cancer therapy;Certification;Chemistry;Clinic;Clinical;clinical care;Clinical Research;clinical translation;Clinical Trials;Coupled;Cyclotrons;design;Development;Diagnosis;Diagnostic;Dissection;Dose;drug action;Drug Labeling;drug testing;efficacy study;Elements;Engineering;Environment;evidence base;Formulation;Funding;Grant;Human;Image;imaging agent;imaging probe;imaging scientist;in vivo;interest;Investigation;investigator-initiated trial;Investments;Journals;Label;Laboratories;Laboratory Research;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;manufacture;medical specialties;Medicine;Methodology;Molecular;molecular imaging;Molecular Target;nanoparticle;New Agents;operation;Paper;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Pharmacology;Physicians;Physics;Physiological;Population;Positron-Emission Tomography;Production;Prognosis;programs;Publications;Publishing;Radiation therapy;Radiochemistry;Radioimmunoconjugate;Radioisotopes;Radiolabeled;Radionuclide Imaging;Radiopharmaceuticals;Research;Research Personnel;Research Support;Schedule;Scientist;Services;Signal Pathway;single photon emission computed tomography;small molecule;Specificity;standard of care;Technology;Therapeutic;Therapeutic Agents;Translating;Translational Research;translational research program;Translations;tumor;Work

PROJECT_TITLE: Radiochemistry and Molecular Imaging Probes


PI_NAMEs: FURUTA, YASUHIDE  (contact)

PROJECT_TERMS: Alleles;Animals;anti-cancer research;blastocyst;Cancer Biology;Cancer Center Support Grant;cell behavior;Cell Culture Techniques;cell growth;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complement;Consultations;CRISPR/Cas technology;Cryopreservation;Derivation procedure;design;Development;DNA;DNA purification;Electroporation;embryo cryopreservation;Embryo Transfer;Embryology;Embryonic Development;embryonic stem cell;gene function;Gene Targeting;Generations;Genes;Genetic;Genetic Engineering;Genetically Engineered Mouse;genome editing;genome integrity;genome sequencing;Genotype;Germ-Line Mutation;Guide RNA;human model;Immunobiology;in vivo;Injections;Investigational Therapies;Malignant Neoplasms;Methods;Microinjections;Mission;Molecular Biology;Molecular Genetics;mouse genetics;mouse genome;mouse model;Mouse Strains;Mus;novel;novel therapeutic intervention;Oncogenes;Operative Surgical Procedures;Performance;Physiological;Pre-Clinical Model;Production;Productivity;Reagent;reconstitution;Recovery;Research Personnel;Role;Services;sperm cell;stem cell biology;Technology;Testing;Time;tissue culture;tool;Training;transcription activator-like effector nucleases;Transgenes;Transgenic Organisms;Translational Research;Tumor Suppressor Genes;tumorigenesis;zygote

PROJECT_TITLE: Mouse Genetics


PI_NAMEs: HAZLE, JOHN D. (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Agreement;Anatomy;Animal Housing;animal imaging;Animals;anti-cancer research;Basic Science;Biochemical;biomedical imaging;Cancer Center;Cancer Center Support Grant;Capital;Complement;Computed Tomography Scanners;Consultations;Contracts;Data;data acquisition;Data Analyses;Dedications;design;Development;Devices;Disease Progression;Ensure;Equipment;experience;Experimental Designs;experimental study;Faculty;Funding;Grant;Housing;Image;imaging biomarker;imaging facilities;imaging study;imaging system;Imaging technology;improved;Income;insight;Institution;instrumentation;Investments;Journals;Laboratories;laboratory facility;Location;magnetic field;Magnetic Resonance;Magnetism;Maintenance;member;Metabolic;metabolic imaging;Methods;minimally invasive;Mission;new technology;novel;Nuclear;operation;optical imaging;Peer Review;photoacoustic imaging;Positron-Emission Tomography;pre-clinical;preclinical imaging;Preparation;programs;prototype;Publications;Publishing;quantitative imaging;Radiation;radiotracer;Reporting;Research;Research Design;Research Personnel;Resources;Rodent;Roentgen Rays;Science;Services;single photon emission computed tomography;Site;System;Technical Expertise;Technology;Tissue Harvesting;tomography;Training;treatment response;tumor;ultrasound

PROJECT_TITLE: 04 Small Animal Imaging Facility


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunization;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Vaccine Related

PI_NAMEs: MULLER, RAYMOND J (contact)

PROJECT_TERMS: Adjuvant;Biological Assay;Cancer Center Support Grant;cancer therapy;Carbohydrates;Child;Clinical;clinical application;Clinical Research;Complex;cost;design;Development;dosage;Dosage Forms;drug development;Drug Evaluation;Drug Formulations;drug release kinetics;early phase clinical trial;effective therapy;Ensure;Formulation;Good Manufacturing Process;improved;Infrastructure;innovation;Institutional Review Boards;interest;Investigational Drugs;Journals;Keyhole Limpet Hemocyanin;Laboratory Finding;leukemia;Malignant neoplasm of ovary;Malignant Neoplasms;manufacture;Manufacturer;Mesothelioma;monoclonal antibody 3F8;Neuroblastoma;novel;operation;Outsourcing;Patients;Peptide Vaccines;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacy facility;Phase;phase I trial;Phase II Clinical Trials;preclinical study;Preparation;Production;programs;Protocols documentation;Publications;Radiopharmaceuticals;Reagent;Refractory;Research;research clinical testing;Research Personnel;Research Support;Resources;Safety;Sarcoma;Serous;Services;skills;small molecule;Sterility;Subgroup;Therapeutic Agents;Therapeutic antibodies;Time;Translational Research;Translations;vaccine evaluation;Vaccines;Vertebral column;Vial device;Work

PROJECT_TITLE: Research Pharmacy


PI_NAMEs: WISTUBA, IGNACIO I. (contact)

PROJECT_TERMS: Accreditation;Animal Model;animal tissue;Animals;biobank;Biological;Biological Markers;Blood;Blood Cells;Blood specimen;Board Certification;Cancer Center;Cancer Center Support Grant;Capital;Cataloging;cell fixing;cell free DNA;Cell Separation;Cells;Cerebrospinal Fluid;Clinical Laboratory Improvement Amendments;Clinical Trials;Collection;Consent;Consultations;Core Facility;Cytology;data management;digital pathology;Equipment;exosome;flexibility;Funding;Genomics;Goals;Grant;Guidelines;Head;Health protection;Histology;Human;human subject;human subject protection;human tissue;Immune;Immunohistochemistry;Immunology procedure;immunotherapy clinical trials;improved;In Situ;In Situ Hybridization;Information Protection;innovation;Institution;Institutional Review Boards;International;Journals;Laboratories;laboratory facility;laser capture microdissection;liquid biopsy;Liquid substance;Medicine;member;Molecular;molecular pathology;Paper;Pathologist;Pathology;Patients;Peer Review;Plasma;pre-clinical;Procedures;Process;process optimization;professor;programs;Protocols documentation;Publications;quality assurance;Quality Control;recruit;repository;Research;Research Personnel;research study;Resource Sharing;Resources;Secure;Services;Slide;Societies;Specimen;Stains;Standardization;System;Tissue Banks;Tissue Microarray;Tissue Procurements;tissue resource;Tissues

PROJECT_TITLE: 05 Tissue Biospecimen and Pathology Resource


PI_NAMEs: GONEN, MITHAT  (contact)

PROJECT_TERMS: Adopted;anti-cancer research;Area;Biological Assay;Biometry;Biostatistics Core;Cancer Center;Cancer Center Support Grant;Charge;Clinical Trials;Clinical Trials Design;Collaborations;cost;Data;design;Development;Diagnostic Procedure;early phase clinical trial;Educational Activities;Eligibility Determination;Epidemiologic Methods;Evidence Based Medicine;experience;Faculty;Funding;Genetic;genomic data;Genomics;Grant;Human Resources;Image;improved;Individual;Institution;Interdisciplinary Study;Master of Science;Medicine;member;Mentors;Methodology;Methods;Mission;Observational Study;Pilot Projects;Plants;Population Genetics;programs;Protocols documentation;Psychometrics;Publications;Recovery;recruit;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Services;Statistical Data Interpretation;Survival Analysis;System;Techniques;Training;United States National Institutes of Health;Work

PROJECT_TITLE: Biostatistics


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Services

PI_NAMEs: ATKINSON, THOMAS MICHAEL (contact)

PROJECT_TERMS: Adverse event;Assessment tool;Behavioral;behavioral and social science;Behavioral Research;Cancer Center Support Grant;Caregivers;Clinical;Clinical Research;Clinical Trials;Collaborations;Communities;community engaged research;community engagement;Consultations;Data;design;experience;Faculty;Feedback;Focus Groups;Funding;Grant;Health;Health behavior change;health related quality of life;High-Risk Cancer;Information Dissemination;Institution;instrument;Interview;Language;Linguistics;Malignant Neoplasms;Measures;member;Methodology;Minority Groups;Mission;National Cancer Institute;novel;Nurses;Observational Study;Oncology;Outcome Measure;patient engagement;Patient Outcomes Assessments;Patient Self-Report;Patients;Peer Review;Physicians;Population Heterogeneity;Population Research;Population Sciences;programs;protocol development;Proxy;Psychometrics;psychosocial;Publications;Qualitative Research;Quality of Care;Reporting;Research;Research Methodology;Research Personnel;research study;Research Support;service engagement;Services;sound;Surveys;Symptoms;tool;Training;United States Food and Drug Administration;Work

PROJECT_TITLE: The Patient-Reported Outcomes, Community-Engagement and Language (PRO-CEL) Core


PI_NAMEs: ANDREEFF, MICHAEL  (contact)

PROJECT_TERMS: Address;anti-cancer research;Antibodies;antibody conjugate;Applications Grants;Authorship;Budgets;cancer cell;Cancer Center;Cancer Center Support Grant;Capital Financing;Cataloging;Cell Separation;cell type;Cells;cellular imaging;Certification;Collaborations;Communities;complex data;Computer software;Consultations;Continuing Education;Core Facility;cost;Custom;Cytometry;Data;Data Analyses;Data Collection;Deposition;design;Education;Equipment;exosome;experimental study;extracellular vesicles;Flow Cytometry;Fluorescence;Fluorescence-Activated Cell Sorting;Fluorochrome;Funding;genomic profiling;Genomics;Grant;Hematopoietic;Heterogeneity;Hour;Human Resources;Image;Image Cytometry;imaging facilities;Imaging Techniques;Immunity;Immunophenotyping;indexing;Industry Standard;innovation;Institution;instrument;instrumentation;interest;International;Investments;Journals;Label;Laboratories;Lead;liquid crystal polymer;lymphoid neoplasm;meetings;member;Methodology;Methods;Molecular;Monoclonal Antibodies;Moon;Myeloproliferative disease;Nature;new technology;particle;Peer Review;posters;Preparation;programs;protein expression;Proteins;Proteomics;Protocols documentation;Publications;Reproducibility;Research;Research Personnel;Resources;satisfaction;Science;Services;single cell analysis;single-cell RNA sequencing;Site;Societies;Solid;Sorting;Source;spectrograph;stem cells;Structure;submicron;symposium;System;Techniques;Texas;Time;Tissue Sample;Tissues;transcriptomics;trend;tumor;Universities;University of Texas M D Anderson Cancer Center;Validation;Vendor;Work

PROJECT_TITLE: 07 Flow Cytometry and Cellular Imaging Facility


NIH_SPENDING_CATS: Bioengineering;Cancer;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SOCCI, NICHOLAS D (contact)

PROJECT_TERMS: algorithm development;Bioinformatics;Biological Assay;Cancer Center Support Grant;cBioPortal;Clinic;Code;Collaborations;Collection;Communities;Computer software;Computing Methodologies;cost effective;cost effectiveness;Data;data access;Data Analyses;Databases;Educational process of instructing;Educational workshop;Ensure;Evaluation;experimental study;Goals;High Performance Computing;Infrastructure;Institution;invention;Laboratories;Maintenance;Methods;Mission;Play;Process;Quality Control;repository;Reproducibility;Research;research and development;Research Personnel;Role;Services;System;Time;tool;Training;Walking;Work

PROJECT_TITLE: Bioinformatics


NIH_SPENDING_CATS: Bioengineering;Cancer;Nanotechnology

PI_NAMEs: HU, JIAN  (contact)

PROJECT_TERMS: Autophagocytosis;Biological;Budgets;cancer cell;Cancer Center;Cancer Center Support Grant;Capital;Cells;Charge;Collection;Consultations;cost comparison;Data;Data Analyses;Dedications;Dryness;Electron Beam;Electron Microscope;Electron Microscopy;Electron Microscopy Facility;Ensure;Environment;Equipment;exosome;experience;Experimental Designs;Faculty;Funding;Goals;Grant;Hour;Image;Institution;instrument;instrumentation;Journals;Label;Malignant Neoplasms;member;Methods;Microscope;microscopic imaging;Microscopy;Mission;Modification;Monitor;nanomaterials;nanoparticle;Nature;operation;Peer Review;Pilot Projects;Preparation;Procedures;Process;programs;Publications;quality assurance;Reproducibility;Research;Research Personnel;Research Project Grants;research study;Resolution;Resources;Risk;sample fixation;Sampling;satisfaction;Scanning;Series;Services;Specimen;Surveys;System;terabyte;Tissue imaging;Training;transmission process;Vacuum;Work

PROJECT_TITLE: 06 High Resolution Electron Microscopy Facility


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: MOHIBULLAH, NEEMAN  (contact)

PROJECT_TERMS: Base Sequence;Basic Science;Bioinformatics;Biological Assay;Blood;Cancer Center;Cancer Center Support Grant;Cells;Chromosome Structures;Clinical Research;Consultations;cost effective;Custom;Data;Data Analyses;data management;design;DNA;DNA analysis;empowerment;Environment;Experimental Designs;frontier;functional genomics;Gene Expression;genomic data;Genomics;Grant;High-Throughput Nucleotide Sequencing;human cancer mouse model;human data;Informatics;interest;Journals;Libraries;member;Metadata;operation;Organism;Paraffin;Pathology;Preparation;Price;Process;Production;programs;Publications;Publishing;Research Personnel;Research Project Grants;Research Support;RNA;Sampling;Scientist;Serum;Services;Software Engineering;System;Technology;Tissues;Translational Research;tumor;Tumor Bank;user-friendly;wasting;Work

PROJECT_TITLE: Integrated Genomics Operations


PI_NAMEs: HENDRICKSON, RONALD CHARLES (contact)

PROJECT_TERMS: Basic Science;Biochemical;Cancer Center;Cancer Center Support Grant;cell growth;Cells;Cerebrospinal Fluid;Clinical Research;Complex;Complex Analysis;Consultations;Custom;Data Analyses;design;Development;Dissection;DNA Repair;experimental analysis;Experimental Designs;Goals;Grant;Immune response;insight;instrumentation;Liquid Chromatography;Liquid substance;Malignant Neoplasms;Mass Spectrum Analysis;member;Microchemistry;Modernization;Molecular;nanoscale;Pathway interactions;Peptides;Post-Translational Protein Processing;programs;Protein Analysis;protein function;protein protein interaction;protein structure;Proteins;Proteomics;Publications;Research;Research Personnel;Research Support;Resolution;response;Sampling;senescence;Services;Signal Pathway;Tissues;Translational Research;user-friendly

PROJECT_TITLE: Microchemistry and Proteomics


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

PI_NAMEs: BOVER, LAURA DEL CARMEN (contact)

PROJECT_TERMS: Affinity;Antibodies;Antibody Affinity;Antigen Targeting;Antigens;assay development;Avidity;Biotechnology;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer immunotherapy;candidate selection;Capital;Cells;Clinical;clinical development;Consultations;Crystallography;Custom;Diagnosis;diagnostic assay;Equipment;experience;Funding;Future;Generations;Goals;Grant;Hand;Human Resources;hybridoma production;Image;Immunohistochemistry;Immunotherapy;improved;In Vitro;insight;interest;Journals;Legal patent;Licensing;Light;member;Mission;Monoclonal Antibodies;Names;new technology;Outcome;OX40;Pathologic;Peer Review;Peptides;Pharmacologic Substance;Phase I Clinical Trials;pre-clinical;Price;programs;Proteins;Publications;Research;Research Personnel;Research Support;Role;Science;Scientist;screening;Services;System;Technology;Therapeutic Uses;tool;Training

PROJECT_TITLE: 08 Monoclonal Antibody Facility


PI_NAMEs: GARIPPA, RALPH J. (contact)

PROJECT_TERMS: 3-Dimensional;Acinus organ component;Biological Process;Biology;Cancer Biology;cancer cell;Cancer Center Support Grant;cancer genome;cancer stem cell;Cell Communication;Cell Line;Cell Physiology;cell type;Cells;Cellular biology;Chemicals;Complex;confocal imaging;cost efficient;CRISPR/Cas technology;Custom;DNA Polymerase II;DNA sequencing;drug discovery;Drug Screening;Epigenetic Process;Event;Feedback;Fluorescence Microscopy;functional genomics;Funding;Gene Targeting;Generations;Genes;genetic technology;genome editing;Genomics;high throughput screening;human disease;human model;Image;Immune;Individual;induced pluripotent stem cell;innovation;Institution;interest;Intracellular translocation;knock-down;Knock-in;Knock-out;Laboratories;Lasers;Libraries;Malignant Neoplasms;matriculation;Mediating;member;Methods;Microscopy;Molecular;Molecular Target;Morphology;multimodality;Mutate;Mutation;new therapeutic target;novel;Oncology;Organoids;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenocopy;Phenotype;Plasmids;Principal Investigator;Proteins;Reagent;Research;Research Personnel;Resolution;RNA Interference;Science;screening;screening program;Services;small hairpin RNA;Small Interfering RNA;small molecule;small molecule libraries;Speed;spheroids;Suspensions;Technology;Therapeutic;tool;tumor initiation;Tumor Suppressor Genes;Untranslated RNA;Vertebral column;whole genome;Zebrafish

PROJECT_TITLE: Genomic Editing & Screening


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Networking and Information Technology R&D (NITRD);Nutrition;Physical Activity;Prevention

PI_NAMEs: PETERSON, SUSAN K (contact)

PROJECT_TERMS: Basen;Behavior assessment;Behavior Therapy;Behavioral Sciences;Budgets;Cancer Center Support Grant;cancer prevention;Cancer Survivorship;Clinical;clinical translation;Core Facility;cost efficient;Data;Data Collection;Development;Diet;Ecological momentary assessment;eHealth;energy balance;exercise intervention;Funding;Grant;Health Technology;Institution;Internet;Intervention;intervention delivery;Journals;Measurement;member;Mission;mobile application;Patient Outcomes Assessments;Peer Review;Physical activity;Physical Function;Population Research;Population Sciences;professor;programs;Publications;Research;research facility;Research Personnel;Resource Sharing;Resources;Science;sensor;service utilization;Services;Surveys;Technology;wearable sensor technology;web app

PROJECT_TITLE: 09 Assessment, Intervention and Measurement Core


PI_NAMEs: VICKERS, SELWYN M (contact)

PROJECT_TERMS: anti-cancer research;Area;Basic Science;Budgets;Cancer Center;Cancer Center Support Grant;Catchment Area;Clinical;Clinical Research;Clinical Sciences;Communication Programs;community engagement;Community Outreach;Comprehensive Cancer Center;Core Facility;Counseling;data management;Discipline;Doctor of Philosophy;Ensure;Evaluation;Evaluation Research;Faculty Recruitment;Financial Support;Fostering;Growth and Development function;high standard;Hospitals;Individual;Infrastructure;innovation;Laboratories;Laboratory Research;Leadership;Malignant Neoplasms;member;Memorial Sloan-Kettering Cancer Center;Mission;Monitor;NCI Center for Cancer Research;outreach;Physicians;Population Heterogeneity;Population Research;Population Sciences;Process;programs;Recommendation;recruit;Research;Research Personnel;Resource Allocation;Resource Development;Resource Sharing;Role;Scientist;Services;Strategic vision;Students;Technology;Training;Training Programs;Translational Research;Work

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Bioengineering;Cancer;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

PI_NAMEs: LEE, J. JACK  (contact)

PROJECT_TERMS: Adopted;analytical method;anti-cancer research;Basic Science;Bayesian Method;Behavioral;Biometry;Cancer Center;Cancer Center Support Grant;cancer prevention;Clinic;Clinical;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Collaborations;Collection;Complex;Computer software;Conduct Clinical Trials;Consensus;Consult;Consultations;Continuing Education;cost;Data;Data Analyses;Data Set;database design;Degree program;design;Development;Doctor's Degree;Drops;Early Diagnosis;Education;Education and Outreach;Educational Curriculum;Educational process of instructing;Educational workshop;Ensure;Exposure to;Faculty;faculty mentor;Fostering;Funding;Futility;Future;Goals;graduate school;graduate student;Grant;Health Services Research;IACUC;improved;Information Technology;innovation;Institution;Institutional Review Boards;inter-institutional;Joints;Knowledge;Laboratories;Laboratory Animals;Lead;lectures;Malignant Neoplasms;member;Mentors;Methods;Mission;Modeling;Monitor;Moon;next generation;novel;Paper;Patient Care;Patient Recruitments;patient safety;Peer Review;Phase;Postdoctoral Fellow;precision oncology;Prevention;Procedures;programs;Protocols documentation;psychosocial;Randomized;Reproducibility;Research;Research Methodology;Research Personnel;Research Training;Resources;Rice;Sample Size;Schedule;Science;Scientist;Services;skills;Statistical Methods;statistics;Structure;Support Groups;Technology;Texas;Toxic effect;Training;Training and Education;training opportunity;Training Programs;Translational Research;United States National Institutes of Health;Universities;web app;web services

PROJECT_TITLE: 10 Biostatistics Resource Group


NIH_SPENDING_CATS: Cancer;Clinical Research;Prevention

PROJECT_TERMS: Acceleration;anti-cancer research;Area;Award;Calibration;Cancer Center;Cancer Center Support Grant;Cancer Etiology;cancer genomics;cancer risk;Categories;Cells;cellular imaging;Clinical Investigator;Collaborations;Communities;Computational Biology;Creativeness;Data Set;Development;Direct Costs;Discipline;Disparity;Evaluation;Faculty;Faculty Recruitment;faculty support;Funding;Funding Opportunities;Goals;Grant;Health behavior;health care delivery;Incentives;Infrastructure;innovative technologies;Institution;Investigation;Investments;Laboratories;Leadership;Manuscripts;member;Mission;multidisciplinary;Peer Review;Peer Review Grants;Pilot Projects;Population;Population Research;Population Sciences;Preparation;Process;programs;recruit;Research;Research Personnel;Resources;Scientist;STEM research;Strategic Planning;Strategic vision;success;Symptoms;System;Talents;Time;United States National Institutes of Health;Writing

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: WEINSTEIN, JOHN N (contact)

PROJECT_TERMS: academic program;Advisory Committees;ATAC-seq;Authorship;Basic Science;Bioinformatics;bioinformatics infrastructure;Bioinformatics Shared Resource;Biological;Biometry;bisulfite sequencing;Cancer Center;Cancer Center Support Grant;career;career development;ChIP-seq;chromatin isolation by RNA purification sequencing;Clinic;Clinical;clinical imaging;Clinical Research;Clinical Trials;Collaborations;college;Computational Biology;computer science;Computer software;computerized tools;computing resources;Consultations;cost;CRISPR/Cas technology;Cytometry;Data;Data Element;data resource;Data Science;Dedications;Development;Discipline;DNA;Doctor of Philosophy;Education;Emotional Intelligence;Evaluation;exome;Faculty;FAIR principles;Flow Cytometry;Flowers;Fluorescence;Funding;Goals;graduate school;Grant;Head and Neck Cancer;Hematologic Neoplasms;Human Resources;Image;Informatics;innovation;Institution;interest;International;interoperability;Journals;Lead;Learning;Life;machine learning method;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;Medical;Medicine;member;metabolomics;method development;Methods;miRNA expression profiling;Mission;Moon;next generation;novel;Output;Paper;Peer Review;Phase;pre-clinical;Principal Investigator;programs;Protein Microchips;Proteomics;Reproducibility;Research;Research Personnel;Resources;Rice;RNA;RNA Interference;Role;Science;Services;small hairpin RNA;Small Interfering RNA;Software Engineering;Specialist;statistical learning;Statistical Methods;Symbiosis;Teacher Professional Development;Time;Training;transcriptome sequencing;Translational Research;United States National Institutes of Health;Universities;user-friendly;Visualization;Walking;web site;whole genome;Work;Writing

PROJECT_TITLE: 11 Bioinformatics Shared Resource


PI_NAMEs: HONG, DAVID S. (contact)

PROJECT_TERMS: Accountability;Beds;Budgets;cancer care;cancer cell;Cancer Center;Cancer Center Support Grant;cancer therapy;Cell Culture Techniques;Cell Separation;Cell Therapy;Center for Translational Science Activities;Client satisfaction;Clinical;Clinical Investigator;Clinical Management;Clinical Research;Clinical Trials;Collection;Complement;Complex;Data;Dedications;Development;Developmental Therapeutics Program;Discipline of Nursing;Doctor of Philosophy;Drug Evaluation;Drug Kinetics;early phase clinical trial;Ensure;Environment;Equipment;Equipment and supply inventories;experience;Faculty;first-in-human;Friends;Funding;Goals;Grant;Infrastructure;innovation;Interdisciplinary Study;Journals;Knowledge;Laboratory Research;Leadership;Learning;Location;Malignant Neoplasms;member;Monitor;Nature;New Agents;new technology;novel;novel strategies;novel therapeutics;Patient Monitoring;patient oriented;Patients;Peer Review;pharmacologic;Phase;phase 2 study;Physicians;Productivity;programs;Publications;Research;Research Activity;Resources;sample collection;Sampling;Scientist;Services;Site;Specimen Handling;Stem cell transplant;System;Testing;Time;tool;Training;Training and Education;Translational Research;translational research program;transplantation therapy;treatment center;Venous blood sampling

PROJECT_TITLE: 12 Clinical and Translational Research Center


PI_NAMEs: LU, YILING  (contact)

PROJECT_TERMS: Algorithms;Animal Model;anti-cancer research;Antibodies;Antibody Repertoire;Apoptosis;Autophagocytosis;Bar Codes;beta catenin;Biological Assay;Budgets;Cancer Center;Cancer Center Support Grant;Capital;career development;Cell Line;Cell surface;Cells;Client;Collaborations;Communities;Computer software;computerized data processing;Contracts;cost effective;Data;data management;data quality;Development;Disease;DNA;DNA Repair;Dot Immunoblotting;Ensure;Environment;Epithelium;Equipment;Faculty;FRAP1 gene;functional status;Funding;Gene Expression;Generations;Genomics;Grant;Immunoblot Analysis;Immunooncology;improved;Individual;innovation;Institution;Integrins;International;Journals;Label;Location;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;MAP Kinase Gene;Measures;Mediating;member;Membrane;Mesenchymal;Messenger RNA;Metabolism;nano-string;Nature;NCI-Designated Cancer Center;Noise;novel strategies;operation;Pathway interactions;Patients;Peer Review;Performance;Phase;Phosphorylation;PIK3CG gene;Post-Translational Protein Processing;Principal Investigator;Procedures;Process;programs;Proliferating;Protein Array;Protein Array Analysis;protein expression;Proteins;Proteomics;Publications;Pyroxylin;Quality Control;receptor;Receptor Protein-Tyrosine Kinases;Reporting;Reproducibility of Results;Research;Research Personnel;Resources;RNA;RNA Probes;Robotics;Sampling;Services;Signal Pathway;Signal Transduction;single molecule;Slide;Solid Neoplasm;Space Perception;Specialist;Spectrophotometry;Stains;System;Systems Biology;Technology;The Cancer Genome Atlas;Therapeutic;Time;tissue/cell culture;transcriptome sequencing;Transforming Growth Factor alpha;trend;tumor;Tumor Tissue;ultraviolet;Update;Variant

PROJECT_TITLE: 13 Functional Proteomics Reverse Phase Protein Array Core


PI_NAMEs: YU, DIHUA  (contact)

PROJECT_TERMS: Antineoplastic Agents;assay development;Basic Science;Biological Assay;Budgets;Cancer Biology;Cancer Center;Cancer Center Support Grant;Capital;Cell Line;Cell model;Cells;cellular oncology;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;Consultations;Core Grant;CRISPR interference;CRISPR library;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Custom;Data;Data Analyses;Department chair;Development;drug discovery;Drug resistance;Eligibility Determination;Equipment;Experimental Designs;functional genomics;Funding;Future;gain of function;gene function;Genes;Genetic;Genetic Screening;Genetic Transcription;Genome;genome editing;genome wide screen;genome-wide;Genomic Library;Genotype;Grant;Guide RNA;high throughput screening;Human;Human Genome;imaging system;improved;Individual;Institution;Journals;Knock-out;knockout gene;Laboratories;Lentivirus;Libraries;Liquid substance;loss of function;Malignant Breast Neoplasm;Malignant neoplasm of brain;member;Mission;molecular oncology;Monitor;Mus;Nature;Neoplasm Metastasis;new technology;new therapeutic target;Oncogenes;Open Reading Frames;operation;Pathway interactions;Peer Review;Phenotype;Principal Investigator;programs;Protocols documentation;Publications;Repression;Research;Research Personnel;Resources;RNA library;Robot;Scientist;screening;Screening procedure;Services;small hairpin RNA;Technology;therapeutic gene;tool;Training;translational cancer research;Translational Research;Tumor Suppressor Proteins;Universities

PROJECT_TITLE: 14 Functional Genomics Core


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PI_NAMEs: BODURKA, DIANE  (contact)

PROJECT_TERMS: Accreditation;anti-cancer research;Appointment;Area;Audience Research;Cancer Center Support Grant;cancer prevention;Cancer Science;career;career development;Clinical;clinical practice;clinical translation;Collaborations;Collection;college;Communication;Communities;Competence;Data;design;Development;disability;Education;education research;Educational Activities;educational atmosphere;Educational Curriculum;Educational Models;Effectiveness;Environment;Evaluation;evidence base;Faculty;faculty mentor;Feedback;Fellowship;Goals;graduate school;Grant;Health Occupations;Health Professional;high school;Human Resources;improved;Incubators;Individual;innovation;Institution;instructor;interdisciplinary collaboration;Interdisciplinary Study;Knowledge;Leadership;Learning;learning strategy;Malignant Neoplasms;Mentored Clinical Scientist Development Program;Mentors;Mentorship;method development;Minority;Minority Health Research;Mission;Monitor;multidisciplinary;novel;novel strategies;Physicians;Postdoctoral Fellow;Preparation;Prevention;prevention practice;professional students;Program Evaluation;programs;Qualifying;recruit;Research;Research Methodology;Research Personnel;Research Training;Resources;response;responsible research conduct;Role;Schools;Science;Scientist;Series;Services;Structure;success;survivorship;synergism;Time;Training;Training and Education;Training Programs;Translations;Underrepresented Minority;University of Texas M D Anderson Cancer Center;Vocational Guidance;Woman

PROJECT_TITLE: Cancer Research Career Enhancement and Related Activities


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Women's Health Research

PI_NAMEs: WOOD, RICHARD D (contact)

PROJECT_TERMS: Acetylation;Address;American Cancer Society;anti-cancer research;Apoptosis;authority;Basic Science;Biochemical;Biological Models;BRCA1 gene;Breast Cancer Cell;Bromodomain;Caenorhabditis elegans;cancer cell;Cancer Center Support Grant;cancer diagnosis;cancer genetics;cancer prevention;cancer therapy;Cell Cycle Checkpoint;Cell division;cell growth;Cell Physiology;Cell Proliferation;Cells;Chromatin;Collaborations;Department of Defense;Development;Diagnosis;Diagnostic;Disease;DNA Damage;DNA Repair;DNA Sequence Alteration;environment related cancer;environmental agent;Epigenetic Process;epigenomics;Etiology;Evolution;Exposure to;Functional disorder;Funding;Genes;Genetic;genetic approach;Genetic Models;Genetic Transcription;Genome;genome integrity;Genomic approach;Genomics;Goals;Grant;Growth;Heterogeneity;Histones;Homeostasis;Human;inter-institutional;International;Journals;leukemia;leukemia/lymphoma;Lysine;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;member;model organism;Molecular;Molecular Chaperones;multidisciplinary;Mus;Mutate;Mutation;Nature;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;Normal Cell;novel diagnostics;novel therapeutics;Oncogenes;Paper;Pathogenesis;Pathway interactions;Patients;Peer Review;Population;Post-Translational Protein Processing;Prevention;programs;protein complex;Protein Family;Proteins;Publishing;Reader;Regulation;Regulatory Pathway;repaired;Research;Resource Sharing;response;Role;Sampling;Science;Signal Pathway;small molecule inhibitor;Societies;Source;Stress;System;Therapeutic;therapeutically effective;therapy resistant;Tissues;TP53 gene;tumor;Tumor Suppressor Proteins;tumorigenesis;Zebrafish

PROJECT_TITLE: 25 Cancer Genetics and Epigenetics


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunization;Immunotherapy;Microbiome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Vaccine Related

PI_NAMEs: ALLISON, JAMES P (contact)

PROJECT_TERMS: adaptive immune response;anti-CTLA4;anti-PD1 therapy;authority;Automobile Driving;Basic Science;Biological;Cancer Center;Cancer Center Support Grant;cancer immunotherapy;cancer therapy;Cancer Vaccine Related Development;Cancer Vaccines;Cells;Clinical;Clinical Research;clinical translation;Clinical Trials;Collaborations;collaborative environment;combinatorial;Combined Modality Therapy;Data;design;Development;Disease;Enrollment;Environment;experience;Failure;fecal transplantation;Fostering;Funding;Goals;Grant;gut microbiome;Human Papilloma Virus Vaccination;immune checkpoint;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunologic Monitoring;Immunologist;Immunology;immunoregulation;Immunotherapy;improved;Innate Immune Response;International;Journals;leukemic stem cell;Link;Mainstreaming;Malignant Neoplasms;member;Molecular;Nature;novel;novel drug combination;novel vaccines;Paper;Patient Monitoring;patient subsets;Patient-Focused Outcomes;Patients;Peer Review;Population;Pre-Clinical Model;preclinical study;Prevention;programs;Publishing;rational design;Relapse;Research;research study;Resource Sharing;response;Sampling;Science;Side;Source;standard of care;stem cells;success;synergism;T cell therapy;T-Lymphocyte;Testing;Translating;translational immunology;Translational Research;Translations;treatment response;tumor immunology;tumor microenvironment;tumor-immune system interactions;vaccination strategy;virus related cancer;Work

PROJECT_TITLE: 04 Immunology


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PROJECT_TERMS: angiogenesis;Animal Model;Biological;Biology;breast cancer metastasis;Cancer Biology;cancer cell;Cancer Center Support Grant;cancer initiation;cancer stem cell;Cells;Cellular biology;Chalk;Chemoresistance;Collaborations;Development;Disease;Disseminated Malignant Neoplasm;Educational workshop;engineered exosomes;Epigenetic Process;Epithelium;Event;exosome;Fibrosis;Funding;Genetic;Genomics;Goals;Grant;Growth;Growth Factor Receptors;histone modification;improved;Inflammation;inter-institutional;interest;International;Joints;Journals;Laboratory Study;Lead;Link;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;member;Mesenchymal;Metabolism;Metastasis Induction;MicroRNAs;Molecular;Nature;Neoplasm Metastasis;novel;novel therapeutics;Oncogenic;Paper;Pathway interactions;Peer Review;Post-Translational Protein Processing;prevent;programs;PTEN gene;Publications;Publishing;Receptor Protein-Tyrosine Kinases;Research;Resource Sharing;Role;Series;Signal Pathway;Signal Transduction;therapeutic target;therapy resistant;tumor;Tumor Biology;tumor metabolism;tumor microenvironment;tumor progression;Untranslated RNA

PROJECT_TITLE: 26 Cancer Biology and Metastasis


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Prevention;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: PUDUVALLI, VINAY K (contact)

PROJECT_TERMS: Address;Automobile Driving;Basic Science;Behavior;bench to bedside;Biological;Brain;Brain Neoplasms;Cancer Biology;cancer cell;Cancer Center Support Grant;Cell Cycle Progression;Cells;Cellular Metabolic Process;Central Nervous System;Central Nervous System Neoplasms;Cerebrospinal Fluid;Characteristics;Clinical Research;Clinical Trials;Collaborations;combinatorial;Cranial Irradiation;Development;Diagnosis;Disease;Drug Kinetics;Early Diagnosis;Early identification;educational atmosphere;Endothelium;Evaluation;Excision;Failure;Funding;Genetic;Genets;Glioblastoma;Glioma;Goals;Grant;Growth;Heterogeneity;Immune;immune activation;Immunotherapeutic agent;Immunotherapy;improved;Individual;innovation;International;Investments;Journals;Knowledge;Laboratories;Leadership;Learning;liquid biopsy;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;member;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Central Nervous System;Molecular;multidisciplinary;Nature;Neoplasm Metastasis;Neurosurgeon;novel;Oncologist;Operative Surgical Procedures;Outcome;Patients;Peer Review;Penetration;Pharmaceutical Preparations;Phase II Clinical Trials;Physicians;prevent;programs;Publications;Quality of life;radiation resistance;Radiation therapy;Radiosurgery;Research Personnel;Risk;Role;Scientist;self-renewal;Serum;small molecule;Source;standard of care;stem cell differentiation;stem cells;Supporting Cell;System;targeted treatment;temozolomide;The Cancer Genome Atlas;Therapeutic;Therapeutic Agents;Therapeutic Uses;Toxic effect;trafficking;transcriptome;Translational Research;Treatment Efficacy;treatment strategy;tumor;Tumor Biology;tumor heterogeneity;tumor microenvironment;University of Texas M D Anderson Cancer Center;Viral

PROJECT_TITLE: 05 Brain Cancer


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prevention;Women's Health Research

PI_NAMEs: WOODWARD, WENDY A (contact)

PROJECT_TERMS: Address;advanced disease;American Joint Committee on Cancer;anti-cancer research;Area;base;Basic Science;Biological Assay;Biological Factors;Biology;biomarker driven;biomarker identification;Breast;breast cancer metastasis;Breast Cancer Patient;Breast Cancer Treatment;breast surgery;burden of illness;Cancer Center Support Grant;Catchment Area;CCNE1 gene;Cell Cycle;Cells;Clinical;Clinical Investigator;clinical practice;Clinical Research;Clinical Trials;cohort;Collaborations;Communication;Cytoplasm;data registry;Development;Diagnosis;Diagnostic Neoplasm Staging;Disease;DNA Repair;early detection biomarkers;Early Diagnosis;effective therapy;Epithelium;ERBB2 gene;Evolution;Faculty;FRAP1 gene;Funding;Generations;Genetically Engineered Mouse;Genets;genomic profiling;Genomics;Goals;Grant;improved;Incidence;Individual;innovation;interest;Investments;Journals;Knowledge;Laboratories;Link;Long-Term Effects;Longevity;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Maps;Measures;Mediator;Medical Oncologist;member;Mesenchymal;Metastatic Neoplasm to the Bone;Methods;MicroRNAs;Minor;Modeling;Molecular;molecular marker;Morbidity - disease rate;mortality;Mutation;Nature;Neoplasm Metastasis;neoplasm registry;neoplastic cell;novel therapeutic intervention;novel therapeutics;overexpression;Paper;Pathway interactions;Patients;Peer Review;personalized medicine;Phenotype;Philanthropic Fund;Population;population based;Population Study;pre-clinical;predicting response;Prevention;Primary Neoplasm;Prognosis;prognosis biomarker;prognostic;programs;Publishing;Publishing Peer Reviews;recruit;Research;Research Infrastructure;Research Personnel;Resistance;Resource Sharing;Signal Transduction;single cell sequencing;Staging System;Subgroup;Surgical Oncologist;System;targeted treatment;Techniques;Technology;Texas;Therapeutic;therapeutic target;TP53 gene;Translating;Translational Research;treatment effect;treatment response;treatment strategy;trend;triple-negative invasive breast carcinoma;tumor growth;tumor heterogeneity;tumor initiation;tumor progression;Tumor stage;tumorigenesis;United States;vector;Wages;Woman

PROJECT_TITLE: 06 Breast Cancer


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Precision Medicine;Prevention;Rare Diseases

PI_NAMEs: KOPETZ, SCOTT  (contact)

PROJECT_TERMS: Address;Adoptive Cell Transfers;Agreement;bench to bedside;Blood;BRAF gene;cancer cell;Cancer Center Support Grant;Cancer Therapy Evaluation Program;Caring;Catchment Area;Cells;Characteristics;chemotherapy;Cholangiocarcinoma;Clinical;Clinical Trials;Collaborations;Colorectal Cancer;Combination immunotherapy;combinatorial;Consensus;Data;Detection;Development;Direct Costs;Disease;drug development;Early Detection Research Network;Early Diagnosis;EGFR inhibition;Excision;Exclusion;Exhibits;Funding;Future;Genes;Genetic;Genets;Grant;Heterogeneity;Immune;immune activation;Immune checkpoint inhibitor;immune modulating agents;Immunocompetent;Immunology;Immunotherapy;improved;Individual;Inherited;Institution;inter-institutional;Interdisciplinary Study;International;Investments;ipilimumab;Journals;Knowledge;Leadership;MADH4 gene;malic enzyme;Malignant neoplasm of anus;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical Oncology;member;Metabolic;Methods;Microsatellite Instability;Modeling;Molecular;molecular subtypes;Molecular Target;Monitor;mTOR inhibition;Nature;Neoplasm Metastasis;neuroendocrine cancer;Neurosecretory Systems;Nivolumab;novel strategies;Oncolytic viruses;Operative Surgical Procedures;Pancreatic Ductal Adenocarcinoma;Paper;Pathology;Patient Selection;Patients;Peer Review;Peptide Vaccines;Pharmacologic Substance;pre-clinical;Precision therapeutics;preclinical study;Prevention;Prevention trial;Process;Program Development;programmed cell death protein 1;programs;Publishing;Regimen;Research;research clinical testing;Resistance;Resource Sharing;Risk;Risk Reduction;Science;screening;Site;Southwest Oncology Group;standard of care;Syndrome;targeted treatment;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Tissues;trafficking;Translating;Treatment Efficacy;Treatment Failure;tumor;Tumor Biology;tumor heterogeneity;tumor microenvironment;tumor-immune system interactions;Work

PROJECT_TITLE: 07 Gastrointestinal Cancers


NIH_SPENDING_CATS: Biotechnology;Cancer;Cervical Cancer;Clinical Research;Health Services;Orphan Drug;Ovarian Cancer;Prevention;Rare Diseases;Uterine Cancer;Vaginal Cancer;Women's Health Research

PI_NAMEs: SOOD, ANIL K (contact)

PROJECT_TERMS: Algorithms;Basic Science;bevacizumab;Biological Markers;Biological Products;Biology;CA-125 Antigen;cancer cell;Cancer Center Support Grant;cancer genetics;cancer prevention;cancer therapy;Caring;cascade genetic testing;chemotherapy;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Developmental Therapeutics Program;Direct Costs;Disease;disorder prevention;Early Detection Research Network;Early Diagnosis;Funding;Future;genomic platform;Goals;Grant;Gynecologic Oncology;Gynecologic Oncology Group;Health Care Costs;health care delivery;Health Services Research;Human Papilloma Virus-Related Malignant Neoplasm;imaging study;Immunotherapeutic agent;improved;improved outcome;Incidence;innovation;inter-institutional;Investments;Journals;Knowledge;Laboratory Research;Laparotomy;Maintenance Therapy;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of ovary;member;molecular marker;Molecular Target;Moon;mortality;multidisciplinary;Neoplasm Metastasis;next generation;novel;Oncology;operation;Operative Surgical Procedures;Paper;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Peer Review;Phase III Clinical Trials;Platinum;Predictive Value;Prevention;programs;Publications;Publishing;Recurrence;Research;research clinical testing;research study;Residual Neoplasm;Resource Sharing;response;screening;Screening for Ovarian Cancer;Serous;Signal Pathway;surgery outcome;therapeutic target;Translating;Translational Research;tumor;Tumor Biology;Tumor Debulking;tumor growth;tumor microenvironment;Uterine Cancer

PROJECT_TITLE: 08 Gynecological Cancers


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Infectious Diseases;Orphan Drug;Precision Medicine;Prevention;Rare Diseases;Rehabilitation;Sexually Transmitted Infections

PI_NAMEs: LAI, STEPHEN Y (contact)

PROJECT_TERMS: Address;advanced disease;Aerodigestive Tract;American;Angiogenesis Inhibitors;Area;Biopsy;Cachexia;Cancer Center Support Grant;cancer therapy;cancer type;Cell Line;Chemoprevention;Chemotherapy and/or radiation;Clinical Investigator;Clinical Research;Collaborations;compare effectiveness;Deglutition;Diagnosis;Diagnostic Neoplasm Staging;DNA Sequence Alteration;Doctor of Philosophy;Early Diagnosis;Endocrinologist;Functional disorder;functional genomics;Functional impairment;functional outcomes;Funding;Genetic;Genomics;Goals;Grant;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;HPV-High Risk;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;hypopharynx;image guided;imaging detection;Immune;immune activation;Immune response;Immunobiology;Immunologics;Immunology;Immunoprevention;Immunotherapeutic agent;Immunotherapy;improved;Incidence;Infection;inter-institutional;interest;Intervention;Joints;Journals;Larynx;Leadership;Major salivary gland structure;malignant mouth neoplasm;Malignant neoplasm of pharynx;Malignant neoplasm of thyroid;Malignant Neoplasms;malignant oropharynx neoplasm;member;Minor salivary gland structure;Molecular;Molecular Target;molecular targeted therapies;Monitor;mortality;Multicenter Studies;National Institute of Dental and Craniofacial Research;new therapeutic target;Normal tissue morphology;novel;Operative Surgical Procedures;oral cancer prevention;Oral cavity;Oral Sex;Oropharyngeal Head and Neck Squamous Cell Carcinoma;Paper;Pathogenicity;patient derived xenograft model;Patient-Focused Outcomes;Patients;Peer Review;Physicians;Play;Precision therapeutics;predicting response;Prevalence;Prevention;programs;prophylactic;Public Health;Publishing;Quality of life;Radiation therapy;reduce symptoms;Rehabilitation therapy;Reporting;Research;Research Institute;Research Personnel;Resistance;resistance mechanism;Resource Sharing;Role;Science;Scientist;screening;Site;Societies;Specimen;Squamous cell carcinoma;Staging System;Supportive care;Surgical Oncologist;Symptom Burden;Symptoms;targeted treatment;The Cancer Genome Atlas;therapeutic target;Therapy trial;Tissues;Tobacco use;Toxic effect;Translational Research;translational study;transmission process;Treatment-related toxicity;trend;tumor;tumor-immune system interactions;Tyrosine Kinase Inhibitor;Vaccines

PROJECT_TITLE: 09 Head and Neck Cancer


PI_NAMEs: HEYMACH, JOHN V. (contact)

PROJECT_TERMS: Area;Award;Basic Science;Biology;biomarker driven;bridge program;Cancer Biology;Cancer Center Support Grant;cancer diagnosis;Cancer Patient;Cell Line;chemotherapy;Clinical;Clinical Research;Clinical Trials;Collaborations;Combined Modality Therapy;Complement;Development;Direct Costs;Disease;DNA Sequence Alteration;Dreams;Epidermal Growth Factor Receptor;epithelial to mesenchymal transition;Exhibits;experience;Faculty;Funding;Gene Modified;Genomics;Goals;Grant;Immune;Immune Evasion;Immune system;Immune Targeting;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;in vivo;innovation;Institution;interest;Intervention Trial;Journals;KRAS2 gene;Laboratory Research;Leadership;Lung;Malignant neoplasm of lung;Malignant Neoplasms;member;Mentors;Modeling;Moon;mouse model;multidisciplinary;mutant;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Paper;Patients;Pattern;Peer Review;personalized approach;personalized therapeutic;Play;pre-clinical;pre-clinical research;preclinical study;programmed cell death ligand 1;programs;Publications;Publishing;Radiation;Radiation therapy;Regimen;Research;Research Personnel;Resistance;response;Role;sample collection;Science;Scientist;Signal Pathway;Signal Transduction;small cell lung carcinoma;standard of care;Surgeon;targeted agent;targeted treatment;Texas;Therapeutic;therapeutic biomarker;therapeutic target;therapy resistant;tool;Translational Research;translational research program;treatment response;tumor;Tumor Immunity;tumor-immune system interactions;Universities;Work

PROJECT_TITLE: 10 Lung Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Precision Medicine;Prostate Cancer;Urologic Diseases

PI_NAMEs: LOGOTHETIS, CHRISTOPHER J. (contact)

PROJECT_TERMS: Address;Affect;Androgen Antagonists;Androgen Receptor;Androgens;Antigen-Presenting Cells;beta catenin;Biological;Biological Markers;Biological Models;Biology;biomarker identification;Blood;Blood Tests;bone;Cancer Biology;cancer cell;Cancer Center Support Grant;Cancer Patient;carcinogenesis;Cell Communication;Cells;CHEK1 gene;Clinic;Clinical;clinical application;clinical development;clinical efficacy;Clinical Research;Clinical Trials Design;clinically relevant;Collaborations;CTLA4 blockade;Development;Disease;Drug resistance;effective therapy;Endothelial Cells;epigenomics;Epithelium;Evolution;exosome;Experimental Models;Failure;Fibroblast Growth Factor;FRAP1 gene;Funding;Gene Expression Profile;Generations;Genetically Engineered Mouse;Genets;Genomics;Germ Lines;Goals;Grant;Growth Factor;Heterogeneity;Immune;immune checkpoint blockade;Immune response;Immune Targeting;Immunology;Immunotherapy;improved;inhibitor;insight;International;Journals;KDR gene;Knowledge;Laboratories;Laboratory Scientists;Link;liquid biopsy;Macrophage;Malignant neoplasm of prostate;Malignant Neoplasms;Marrow;Mediating;Medical Oncologist;member;men;metabolomics;Metastatic Neoplasm to the Bone;Methods;Modeling;Molecular;Mutation;Myeloid-derived suppressor cells;Nature;neoplastic cell;New Agents;novel;novel therapeutic intervention;novel therapeutics;Paper;patient derived xenograft model;patient response;Patients;Peer Review;Phenotype;Physicians;PI3K/AKT;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;predicting response;Prediction of Response to Therapy;predictive marker;prognostication;programs;progression marker;prostate biopsy;prostate cancer cell;prostate cancer progression;Prostate Cancer therapy;Publications;Publishing;Radium;Receptor Signaling;Recurrent tumor;Refractory;Reporting;Research;Resistance;resistance mechanism;Resource Sharing;response;Role;Scientist;Signal Pathway;Signal Transduction;standard of care;System;T-Lymphocyte;targeted agent;targeted treatment;Technology;Testing;Therapeutic;therapy development;Time;tissue resource;Tissue Sample;Tissues;tool;Translating;treatment response;tumor;Tumor Biology;tumor microenvironment;Tumor Tissue;Urine;Variant

PROJECT_TITLE: 11 Prostate Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

PI_NAMEs: ORLOWSKI, ROBERT ZYGMUNT (contact)

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Immunotherapy;Affect;Agammaglobulinaemia tyrosine kinase;Antibodies;Apoptosis;Apoptotic;Area;authority;BCL-2 Protein;Bcr-Abl tyrosine kinase;Biological Markers;Biology;biomarker driven;cancer cell;Cancer Center Support Grant;CD19 gene;Cell Compartmentation;Cell Therapy;Cells;Cellular biology;Clinic;Clinical;Clinical Investigator;Clinical Trials;Collaborations;Development;Developmental Therapeutics Program;Disease;drug discovery;Drug resistance;Epigenetic Process;epigenome;Funding;Genetic;Goals;Grant;Hematologic Agents;Hematologic Neoplasms;Hematopoietic;Heterogeneity;Immune;Immunology;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;individual patient;Industry;innovation;Innovative Therapy;inter-institutional;interest;Investigation;JAK2 gene;Journals;Knowledge;Laboratories;leukemia;Lymphoid Cell;Lymphoma;Malignant - descriptor;Malignant Neoplasms;Medical;member;Modification;Molecular;Moon;multidisciplinary;Multiple Myeloma;Myeloid Cells;National Cancer Institute;neoplastic cell;New Agents;novel;novel therapeutics;Pathway interactions;Patient-Focused Outcomes;Patients;Peer Review;personalized medicine;Pharmaceutical Preparations;Phase;Phenotype;Physicians;Plasma Cells;Pre-Clinical Model;preclinical study;prevent;programs;proteostasis;Publications;Research;Research Personnel;Residual Neoplasm;Resistance;Resource Sharing;Role;Scientist;Signal Transduction;small molecule inhibitor;stem cell biology;Stem cell transplant;targeted treatment;Testing;therapy development;Translating;Translation Initiation;translational scientist;translational study;Translations;transplantation therapy;Treatment Failure;treatment strategy;tumor;Tumor Biology;tumor initiation;tumor microenvironment;tumor-immune system interactions;United States Food and Drug Administration;Vaccines;Work

PROJECT_TITLE: 12 Hematologic Malignancies


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Hematology;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Transplantation

PI_NAMEs: SHPALL, ELIZABETH J (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;Adult;Allogenic;Antigen Targeting;antigen-specific T cells;Antigens;Area;Autologous;Biological;Biology;Bone Marrow;Cancer Center Support Grant;cancer stem cell;cancer therapy;CAR T cell therapy;CD94 Antigen;Cell Therapy;Cell Transplantation;Cells;cellular development;Cellular immunotherapy;Chemoresistance;Childhood;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Investigator;Clinical Research;Collaborations;Cord Blood Stem Cell Transplantation;cytokine release syndrome;Cytomegalovirus Infections;cytotoxicity;Development;Disease;Disease Resistance;Dose;effective therapy;Engraftment;Evaluation;experience;Functional disorder;Funding;Genetic;Goals;graft vs host disease;Grant;heart damage;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;hematopoietic stem cell expansion;Hematopoietic Stem Cell Transplantation;hematopoietic transplantation;high risk;Homing;Immune;Immunity;immunoregulation;Immunotherapy;improved;improved outcome;Infection;Infection prevention;Injury;innovation;International;Investments;Journals;leukemia;Life;Lung;Lymphoma;Maintenance;Malignant Neoplasms;manufacturing technology;Measures;Mediating;Medical;member;mesenchymal stromal cell;Modality;Modification;Monoclonal Antibodies;Morbidity - disease rate;mortality;Multicenter Studies;Natural Killer Cells;Natural regeneration;Neurologic;new technology;Normal tissue morphology;novel;novel strategies;Oncology;Organ;Outcome;Patients;Peer Review;Phase I/II Clinical Trial;post-transplant;preclinical study;prevent;Probability;programs;Publications;Publishing;Regenerative Medicine;Regimen;Relapse;relapse risk;Research Personnel;Resource Sharing;response;restoration;Risk Reduction;Safety;Solid;Solid Neoplasm;standard of care;stem cell biology;stem cell population;stem cell therapy;Stem cell transplant;stem cells;Supportive care;System;T-Cell Immunologic Specificity;T-Cell Receptor Therapy;T-Lymphocyte;tissue injury;tissue regeneration;Tissues;Toxic effect;Translational Research;translational scientist;Transplantation;Transplantation Immunology;transplantation medicine;transplantation therapy;Treatment Failure;Treatment outcome;treatment risk;treatment strategy;tumor;Tumor Antigens;tumor immunology;Tumor-Infiltrating Lymphocytes;Umbilical Cord Blood Transplantation;Virus Diseases

PROJECT_TITLE: 13 Stem Cell Transplantation and Cellular Therapy