ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The initiating causes of psoriasis and psoriatic arthritis as well as the link between skin and joint disease are still uncertain and improved knowledge of these factors may lead to novel therapies or aid with diagnosis. Multiple studies have shown that patients with variants of the A20 (Tnfaip3) gene have a higher susceptibility to psoriasis and psoriatic arthritis. This proposal aims to understand how defects in A20 can initiate the inflammatory processes that ultimately lead to psoriatic skin and joint disease.

PI_NAMEs: RAZANI, BAHRAM  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 3-Dimensional;A20 protein;Adult;Advisory Committees;Affect;Anatomy;Antigens;Arthritis;arthropathies;Automobile Driving;Binding;Binding Proteins;Biology;career;career development;Cells;Cellular Immunology;Chronic small plaque psoriasis;Complex;Cutaneous;cytokine;Cytokine Network Pathway;Data;Defect;Development;Development Plans;Diagnosis;Digit structure;Disease;Distal;early detection biomarkers;Early Diagnosis;Educational workshop;Epidermis;Epithelium;Evolution;experimental study;fascinate;Foundations;Functional disorder;Genes;Genetic Polymorphism;Genomics;Germ Lines;Goals;Histologic;Human;Human Characteristics;IL17 gene;Immune;immune cell infiltrate;Immune signaling;Immunologist;Immunology;improved;in vivo;Inflammation;Inflammatory;Inflammatory Infiltrate;Inflammatory Response;joint destruction;joint inflammation;Joints;keratinocyte;keratinocyte differentiation;Knock-in;Knowledge;Leadership;Learning;Link;Location;Mentors;Mentorship;Modeling;Molecular;mouse model;Mouse Strains;multidisciplinary;Mus;mutant;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nature;new therapeutic target;NF-kappa B;novel;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;patient subsets;Patients;Phase;Physicians;Play;Population;Positioning Attribute;Predisposition;prevent;Process;programs;Protein Biochemistry;Proteins;Psoriasis;Psoriatic Arthritis;Publishing;Research;Research Personnel;Rheumatology;Role;Scientist;Series;Signal Pathway;Signal Transduction;skills;Skin;skin disorder;Statistical Data Interpretation;symposium;T-Lymphocyte;therapeutic biomarker;Tissues;TNF gene;transcriptomics;Tumor Necrosis Factor Receptor;two-dimensional;Ubiquitin;United States;Variant;Zinc Fingers

PROJECT_TITLE: Restriction of psoriatic skin and joint disease by A20

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The proposed research has a direct relevance to public health given that epilepsy is one of the most common neurological disorders in the United States, affecting about 3 million adults, among which 30- 40% have seizures that are medically intractable. The present application is in line with the mission of the NIH to develop innovative research strategies to improve public health through an understanding of the basic mechanisms of diseases. It may lead to completely novel insights concerning the pathophysiology of epileptic disease and pave the way to innovative therapies improving sleep homeostasis in order to decrease seizure burden and improve cognitive outcomes in patients with epilepsy.

PI_NAMEs: BOLY, MELANIE  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Adult;Affect;Animal Model;Area;Biological Markers;Brain;Chemosensitization;Chronic;Cognitive;Coma;Conscious;Data;Data Set;density;diagnostic biomarker;diagnostic tool;Disease;Doctor of Philosophy;Down-Regulation;Electroencephalography;Epilepsy;Excision;Frequencies;Functional disorder;Homeostasis;Hour;Human;Impaired cognition;improved;improvement on sleep;Injury;innovation;Innovative Therapy;insight;Link;Medical;Methods;Microelectrodes;Mission;Nervous System Disorder;neuromechanism;Neurons;neuroprotection;Normal Range;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Outcome;Partial Epilepsies;Patients;Pattern;Peripheral;Pharmaceutical Preparations;Population;Procedures;Public Health;recruit;Recurrence;Refractory;Research;Research Personnel;Resolution;Risk;Seizures;Sleep;Slow-Wave Sleep;spatiotemporal;Synapses;Technical Expertise;United States;United States National Institutes of Health;Universities;validation studies

PROJECT_TITLE: electroencephalography and single-unit recordings

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative The cranial neural crest (CNC) cells are multipotent cells can differentiate into different cell types such as bone, cartilage, neurons, and connective tissues, making remarkable contribution to the craniofacial structures. The proposed studies will investigate molecular signals regulate CNC cells migration and differentiation, as well as identify novel target genes during CNC development, with the long term goal of developing new diagnostic and therapeutic tools of craniofacial diseases.

PI_NAMEs: WANG, JUN  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Adipocytes;Affect;antagonist;ATAC-seq;beta catenin;Biological Assay;bone;Calvaria;Cartilage;Cell Differentiation process;cell motility;cell type;Cells;Cephalic;Chondrocytes;Chondrogenesis;Chromatin;chromatin immunoprecipitation;cleft lip and palate;comparison control;Complex;conditional knockout;Congenital Abnormality;Connective Tissue;craniofacial;Craniofacial Abnormalities;craniofacial development;craniofacial structure;craniofacial tissue;Craniosynostosis;Cre driver;Data;Defect;Development;diagnostic tool;Differentiation Antigens;Disease;Embryo;Exhibits;Family;FOXC1 gene;Gene Expression;Genes;Genetic;genome-wide;Goals;Heart;Heterozygote;High-Throughput Nucleotide Sequencing;Human;In Vitro;in vivo;in vivo imaging;insight;knock-down;Knowledge;Life;Ligands;Mandible;melanocyte;migration;Migration Assay;Molecular;molecular phenotype;Morphology;multipotent cell;Mus;mutant;Mutant Strains Mice;Neural Crest;Neural Crest Cell;Neuroglia;Neurons;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;Organ;osteoblast differentiation;Osteoblasts;Pathway interactions;Patients;Phase;Phosphorylation;Phosphotransferases;Play;postnatal;Proliferating;Protein Array;protein protein interaction;Repression;response;Role;Signal Pathway;Signal Transduction;Smooth Muscle;Syndrome;Testing;Time;Tissues;tool;Transcription Coactivator;transcription factor;transcriptome sequencing;Transposase;WNT Signaling Pathway

PROJECT_TITLE: Molecular Regulatory Mechanism of Cranial Neural Crest Development

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: AUGUSTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Cardiovascular disease is the number one cause of mortality in the US. The proposed study focuses on investigating the function and the underlying mechanisms of PIK3C3 in vascular smooth muscle cells. Identification of the key players such as PIK3C3 in smooth muscle phenotypic modulation will provide the foundation for treating or preventing smooth muscle-driven diseases in cardiovascular system.

PI_NAMEs: ZHOU, JILIANG  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Aorta;Area;Arterial Fatty Streak;Atherosclerosis;Attenuated;Autophagocytosis;Autophagosome;Biological;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;Cells;Cellularity;Contractile Proteins;Coronary Arteriosclerosis;Data;Dendritic Cells;Development;Disease;Down-Regulation;Elasticity;Endosomes;Event;Exhibits;femoral artery;Flow Cytometry;Fluorescence;Foundations;Gene Expression;Generations;Genes;Genetic;genome wide association study;genomic data;Histology;Homeostasis;Human;human data;hypercholesterolemia;Hyperplasia;Impairment;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory marker;inhibitor;Injections;Injury;insight;Intestines;Knock-out;Knockout Mice;Lesion;Link;Lipids;Lysosomes;Macrophage;Mediating;Mediator;Membrane;Mesenchymal Stem Cells;Modification;mortality;mouse model;Mus;novel;Pathway interactions;pharmacologic;Phenotype;Phosphotransferases;Play;postnatal;preservation;prevent;Process;protein expression;Proteins;Proteomics;Quantitative Reverse Transcriptase PCR;Reporter;Role;Severities;single-cell RNA sequencing;Smooth Muscle;Smooth Muscle Myocytes;stem cell biomarkers;stem cell genes;Synthetic Genes;T-Lymphocyte;Tamoxifen;Testing;trafficking;transcriptome sequencing;Transgenes;Ubiquitin;Vascular Diseases;Vascular remodeling;Vascular Smooth Muscle;vascular smooth muscle cell proliferation;Verteporfin;Vesicle;Visceral;Western Blotting

PROJECT_TITLE: PIK3C3, a master regulator for smooth muscle identity

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE While we are not conscious of this sister sense to hearing, the vestibular sense maintains balance and controls eye movements during head motions, with dysfunction resulting in incapacitating dizziness and loss of stable vision. This project proposes to elucidate the role of a well-known but poorly understood anatomical feature, the opposing orientation of two populations of sensory cells in the vestibular inner ear organs that sense gravity and linear acceleration. Accomplishment of the research proposed will help the interpretation and design of treatments for dizziness of vestibular origin.

PI_NAMEs: CULLEN, KATHLEEN E;EATOCK, RUTH ANNE;TARCHINI, BASILE ROBIN (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Ablation;Acceleration;Address;Adopted;Adult;Affect;afferent nerve;Age;Anatomy;Animal Model;Anterior;Auditory;Automobile Driving;Behavior;behavior test;Birth;Calcium;Cell Differentiation process;Cell Maturation;Cell Physiology;Cell Polarity;Cells;Cessation of life;Compensation;Complex;Data;Development;Dizziness;Electrophysiology (science);emx2 protein;Ensure;Epithelial Cells;Epithelium;Equilibrium;Evoked Potentials;Eye Movements;Fishes;Frequencies;Functional disorder;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;gaze;Genetic;Genetic Epistasis;Goals;Gravity Perception;GTP-Binding Proteins;Hair;Hair Cells;Head;Head Movements;Hearing;Heterotrimeric GTP-Binding Proteins;Homologous Gene;Image;Impairment;innovation;insight;Intercellular Junctions;interest;Ion Channel;kinetosome;Labyrinth;Lateral;lateral line;macula;Measures;mechanical stimulus;mechanotransduction;Mediating;Modality;Molecular;molecular marker;Motion;Mus;mutant;Mutant Strains Mice;nerve supply;neuromast;Organ;Orphan;Pathway interactions;Pattern;Pertussis Toxin;Phenocopy;Physiology;planar cell polarity;Population;Positioning Attribute;prevent;Process;programs;Proteins;public health relevance;receptor;receptor function;regional difference;Research;response;Role;Saccule and Utricle;Saccule structure;Sense Organs;Sensory;Shapes;signal processing;Signal Transduction;Sister;Stimulus;System;Testing;therapy design;Time;transcription factor;Utricle structure;Vertebrates;Vestibular Diseases;Vestibular dysfunction;Vestibular function;Vestibular inner ear;vestibular system;vestibulo-ocular reflex;virtual;Vision;Visual;water flow;Water Movements;Work;Zebrafish

PROJECT_TITLE: Mechanism and Functional Significance of Polarity Reversal in Mechanosensory Organs

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Retention in care and persistent adherence to antiretroviral therapy are necessary for the successful treatment of HIV infection. HIV-related stigma is a known impediment to the care and health outcomes of people living with HIV. The proposed study will test theory-based interventions designed to manage HIV stigma in order to improve care retention and medication adherence in communities with high-levels of HIV-related stigma.

PI_NAMEs: KALICHMAN, SETH C (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Address;Adherence;Adoption;Adverse effects;adverse outcome;Anti-Retroviral Agents;antiretroviral therapy;arm;barrier to care;Behavior;behavior test;Behavior Therapy;Behavioral;care seeking;care systems;Caring;Cellular Phone;Clinic;Clinical;Clinical Services;Clinical Trials Design;Communities;Community Health Aides;Consolidated Framework for Implementation Research;cost;Counseling;Country;Data;Decision Making;Dedications;design;efficacy testing;efficacy trial;Enrollment;Environment;evidence base;Evidence based intervention;experience;follow-up;Frequencies;Future;Gender;Goals;Health;HIV;HIV Infections;Homophobia;implementation evaluation;implementation research;improved;Informal Social Control;internalized stigma;International;Intervention;intervention effect;Investigation;male;Mediating;medication compliance;men;Modeling;Modification;Outcome;Participant;Patient Education;patient engagement;Patient Recruitments;Patients;Penetration;Persons;pilot test;post intervention;preservation;primary endpoint;primary outcome;Problem Solving;Process;Professional counselor;Provider;Public Health;Randomized;randomized, clinical trials;Recording of previous events;recruit;Research;Research Activity;Resource-limited setting;Resources;Same-sex;scale up;secondary outcome;Self Efficacy;Self Management;Services;skills;social;social stigma;South Africa;South African;standard of care;Stigmatization;System;Technology;Testing;theories;therapy adherence;therapy design;three-arm clinical trial;three-arm trial;trial design;Viral;Woman

PROJECT_TITLE: Intervention to Improve HIV Care Retention and Antiretroviral Adherence inStigmatized Environments

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: NEW YORK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project narrative  Textural aspects of food, termed mouthfeel, are important flavor qualities that can determine whether food is eaten or discarded, and thus, are essential factors for dietary health. Currently, little is known about the basic neuronal mechanisms underlying mouthfeel or the processes by which this flavor modality modifies taste. This work provides a comprehensive identification of mammalian mechanosensory neurons of the tongue and identifies mechanotransduction channels that underlie mouthfeel, with the long-term goal of understanding how mechanosensation impacts flavor perception.

PI_NAMEs: MOAYEDI-ESFAHANI, YALDA  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Affect;Afferent Neurons;Anatomy;Astringents;Auditory;Basic Science;Behavioral;Biology;calcium indicator;Cells;Central Nervous System;Complement;conditional knockout;Consumption;Cre driver;Cues;Data;Deafferentation procedure;Dietary Factors;Dietary intake;Eating;Energy Intake;Esthesia;Family;feeding;Filiform Papilla;Food;food consumption;Food Preferences;food quality;Foundations;Fungiform Papilla;Future;Ganglia;Goals;Health;hedonic;Histology;Human;imaging study;in vivo calcium imaging;Intake;Ion Channel;Ion Channel Gating;Knockout Mice;Knowledge;Label;Mechanical Stimulation;mechanical stimulus;Mechanics;Mechanoreceptors;mechanotransduction;Methods;Modality;Molecular;molecular marker;Morphology;multisensory;Mus;nerve supply;Nervous System;Neuroanatomy;Neurons;Nutrient;Nutritional;Oral;Oral cavity;Organ;Perception;Peripheral;Piezo 1 ion channel;Piezo 2 ion channel;Piezo ion channels;Play;Population;pressure;Process;programs;Property;Publishing;Reporter;Research;response;Role;Sensory;Signal Transduction;SLC17A8 gene;Smell Perception;somatosensory;somesthesis;Stimulus;Structure of trigeminal ganglion;Surveys;Tactile;Taste Perception;Technology;Testing;Texture;Tongue;tongue papilla;tool;Touch sensation;Transgenic Mice;Transgenic Organisms;Trigeminal System;Viscosity;Visual;Work

PROJECT_TITLE: Mechanosensory substrates of flavor in the mammalian tongue

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative Lipid Droplets (LDs) are unusual organelles composed of a neutral lipid core, bounded by a phospholipid monolayer into which specific proteins are embedded. This project will elucidate the molecular mechanisms by which proteins target LDs. Since these proteins include important enzymes of metabolism with strong links to human metabolic diseases, the results from this application will not only reveal fundamental aspects of cell biology but may also provide avenues to treat metabolic diseases, such as for instance fatty liver disease.

PI_NAMEs: WALTHER, TOBIAS C (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Address;Adopted;Atherosclerosis;Binding;Biochemical;Buffers;cell type;Cells;Cellular biology;Cytoplasm;Defect;Development;Disease;driving force;Drosophila genus;Enzymes;fatty liver disease;Funding;Generations;genome wide screen;genome-wide;high risk;Human;Hydrolysis;Industry;insight;Intervention;Lead;Link;lipid metabolism;Lipids;Lipodystrophy;Lipolysis;Liver diseases;Mediating;Membrane;membrane biogenesis;Metabolic;Metabolic Diseases;Metabolism;Modeling;Molecular;Molecular Conformation;monolayer;Monomeric GTP-Binding Proteins;non-alcoholic fatty liver disease;novel therapeutics;Obesity;Oils;Organelles;Organism;Pathology;Pathway interactions;Phase;Phosphatidylinositols;Phospholipids;Physiology;Plants;Process;Proteins;Proteome;Reticulum;SNAP receptor;sterol ester;Surface;Testing;Therapeutic;Triglycerides;Variant

PROJECT_TITLE: Mechanisms of Lipid Droplet Protein Targeting

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: NEUROSURGERY

ORG_STATE: CA

PHR: I will build and enhance on my current research directions through robust collaborations and integration of novel technologies. Specifically, I will: 1) identify and characterize novel glioma neoantigens for safe and effective immunotherapy; 2) develop a novel sequential chimeric antigen receptor system to address heterogeneous expression of glioma antigens; and 3) target the glioma immune environment by creating tertiary lymphoid organs. Integration of these preclinical studies will allow me to develop comprehensive and synergistic immunotherapeutic approaches.

PI_NAMEs: OKADA, HIDEHO  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Adopted;Adult Glioma;Antigen Targeting;Antigen-Presenting Cells;Antigens;Area;Award;Brain;Brain Neoplasms;Cells;chemokine;Childhood Glioma;chimeric antigen receptor;chimeric antigen receptor T cells;Collaborations;Cytotoxic T-Lymphocytes;Data;Engineering;Environment;flexibility;Glioma;Goals;high risk;Homing;Immune;Immune response;Immunology;Immunosuppression;Immunotherapeutic agent;Immunotherapy;immunotherapy clinical trials;Laboratories;lymphoid organ;Malignant Glioma;Malignant Neoplasms;Mediating;National Institute of Neurological Disorders and Stroke;neoantigens;new technology;Normal Cell;notch protein;novel;Oncolytic viruses;Patients;preclinical development;preclinical study;Research;Signal Transduction;Site;success;System;T-Cell Receptor;Technology;tertiary lymphoid organ;Tissues;tumor;Tumor Antigens;tumor microenvironment

PROJECT_TITLE: Preclinical development of breakthrough immunotherapy for brain tumors


NIH_SPENDING_CATS: Anxiety Disorders;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Serious Mental Illness

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative We need targeted, individualized treatments for mental health disorders, which affects nearly 50% of Americans. Brain stimulation treatments target dysfunctional brain networks with minimal side effects but are currently applied in a one-size-fits-all manner, thus limiting its efficacy. I aim to develop a non-invasive personalized brain stimulation platform for neuropsychiatric disorders; here I will create a real-time monitoring system for brain changes, evaluate the mechanism underlying these brain changes, and develop and test an adaptive stimulation paradigm to maximally drive individual brain changes and improve clinical outcome.

PI_NAMEs: KELLER, COREY J (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Affect;Algorithms;American;anti-depressive agents;Award;Bayesian learning;Biological Markers;biomarker development;Book Chapters;Brain;brain based;brain circuitry;brain dysfunction;Brain Mapping;Clinical;clinical predictors;Clinical Trials;Collaborations;Computer Models;Controlled Clinical Trials;Dedications;Department chair;depressed patient;design;Development;diagnostic platform;Discipline;Dose;Double-Blind Method;effective therapy;Electroencephalography;Engineering;Enrollment;Event;FDA approved;Frequencies;Goals;Grant;Health Services Accessibility;Human;Human Resources;improved;Incubators;Individual;individualized medicine;innovation;Institution;instructor;International;Intervention;journal article;Laboratories;lectures;Legal patent;Length;Maps;Measures;Mental Depression;Mental disorders;Mentors;Modality;Modeling;Monitor;Morphologic artifacts;neural network;neuroimaging marker;Neurologist;neuropsychiatric disorder;Neurosurgeon;Obsessive-Compulsive Disorder;Outcome;Patients;Pattern;Physiologic pulse;Placebo Control;placebo controlled study;Placebos;Population;Positioning Attribute;Post-Traumatic Stress Disorders;primary outcome;professor;Publications;Publishing;randomized, clinical trials;real time monitoring;repetitive transcranial magnetic stimulation;Reporting;Research;Residencies;response;Risk;Secure;Severities;side effect;Signal Transduction;Students;substance use;Supervision;System;Techniques;tenure track;Testing;Time;time use;tool;translational neuroscience;treatment optimization;treatment responders;treatment stratification;Update;Work;Writing

PROJECT_TITLE: Closing the loop: development of real-time, personalized brain stimulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: PARKTOWN, JOHANNESBURG

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: AURUM INSTITUTE NPC

PHR: PROJECT NARRATIVE The Aurum South and East African Clinical Trials Unit (ASEA CTU) will implement a comprehensive, integrated strategy to address the HIV and TB pandemics. Our approach is to test new HIV and TB prevention strategies, novel HIV and TB therapeutic agents, and combination and multipurpose prevention interventions, to generate the empirical data to guide future development and implementation of effective HIV and TB strategies.

PI_NAMEs: CHURCHYARD, GAVIN JOHN (contact)

PROGRAM_OFFICER_NAME: GUERRA, MARIA ISABEL

PROJECT_TERMS: Active Immunization;Address;Adherence;Adolescent;adolescent woman;Adult;Africa;African;AIDS clinical trial group;AIDS prevention;Anti-Retroviral Agents;Antibodies;antiretroviral therapy;Behavioral;Cardiovascular Diseases;Caring;clinical research site;Clinical Trials Unit;Collaborations;combat;Communities;community advisory board;comorbidity;Complement;Complex;Couples;dashboard;Data;Development;Disease;Drug Combinations;Drug resistance in tuberculosis;Epidemic;epidemic response;experience;Exposure to;Fishes;Funding;Future;Goals;Health care facility;high risk;high risk men;high risk population;HIV;HIV Antibodies;HIV Infections;HIV vaccine;HIV Vaccine Trials Network;HIV/TB;Home;Human immunodeficiency virus test;Incidence;Individual;Infection;Infrastructure;Infusion procedures;International;Intervention;Knowledge;Leadership;Maps;men;men who have sex with men;neglect;neutralizing antibody;novel;obesity prevention;pandemic disease;Participant;Patients;Persons;Pharmaceutical Preparations;Phase;phase I trial;Play;Population;Populations at Risk;pre-exposure prophylaxis;Predisposition;Pregnancy;prevent;Prevention;Prevention Research;Prevention strategy;Prevention trial;preventive intervention;Preventive therapy;Preventive vaccine;Primary Health Care;Principal Investigator;programs;Recording of previous events;recruit;Recurrence;Regimen;Research;Research Personnel;Research Priority;Resistance;Risk;Role;sex;Sexually Transmitted Diseases;Site;skills;social;South Africa;Southern Africa;Structure;study population;Sum;System;Technology;Testing;Therapeutic;Therapeutic Agents;Time;tool;transmission process;treatment strategy;treatment trial;Tuberculosis;Tuberculosis diagnosis;tuberculosis drugs;tuberculosis treatment;Tuberculosis Vaccines;Uganda;unintended pregnancy;uptake;Vaccination;Vaccines;young woman;Zambia

PROJECT_TITLE: Aurum Clinical Trials Unit


ORG_CITY: AMHERST

ORG_DEPT: PHYSIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Nearly 600,000 adults suffer from cardiac arrest in the United States each year, with the majority of events occurring suddenly in the out-of-hospital setting in seemingly healthy individuals. Although advances in cardiopulmonary resuscitation (CPR) have increased the likelihood of initially restoring a pulse in these individuals, nearly 70% of patients that are admitted to the hospital following resuscitation from cardiac arrest will die before hospital discharge as the result of severe cardiovascular dysfunction and/or brain injury. The proposed studies aim to address this major public health problem by determining whether post-resuscitation injury is caused by activation of the innate immune system and identifying novel treatments that protect the heart, brain, and other organs by modulating the immune-mediated inflammatory response after cardiac arrest.

PI_NAMEs: WEIL, BRIAN RAYMOND (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Acute;Address;Adult;Animal Model;Attenuated;attenuation;beta-2 Adrenergic Receptors;Biology;Brain;Brain Injuries;Cardiopulmonary Resuscitation;Cardiovascular Physiology;Cardiovascular system;chemokine receptor;Circulation;Clinical;Clinical Research;Critical Care;cytokine;Death Rate;Development;effective therapy;Epinephrine;Event;Experimental Designs;Family suidae;Functional disorder;Heart;Heart Arrest;Heart Diseases;Heart Injuries;Hospitals;immune activation;Immunology;immunomodulatory therapies;immunoregulation;improved;Individual;Infiltration;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;Injury to Kidney;Innate Immune Response;Innate Immune System;insight;Intervention;Ischemia;ischemic injury;Knowledge;Leucocytic infiltrate;Leukocytes;Leukocytosis;Life;Lipids;Macrophage;Mediating;Medicine;Micelles;monocyte;monocyte chemoattractant protein 1 receptor;Morbidity - disease rate;multidisciplinary;multiorgan damage;multiorgan injury;Nervous System Physiology;neuroprotection;neutrophil;novel;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Organ;organ injury;Patient Admission;Patients;pharmacologic;Physiologic pulse;Play;porcine model;Process;Prognosis;Public Health;receptor-mediated signaling;Reperfusion Therapy;Research;Resuscitation;Role;Science;Severities;Spleen;Splenectomy;Survival Rate;Syndrome;systemic inflammatory response;Testing;therapeutic target;tissue injury;Tissues;Treatment Efficacy;treatment strategy;United States;White Blood Cell Count procedure

PROJECT_TITLE: Immunomodulatory Therapy After Resuscitation From Cardiac Arrest

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: COLUMBIA

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: SC

PHR: Project Narrative Exposure to traumatic stress, as is common during combat, can lead to post traumatic stress disorder (PTSD) in susceptible individuals. As such, the lifetime prevalence of PTSD in combat soldiers is 6-30%. In addition to the debilitating consequences on mental health, PTSD is associated with an increased risk of developing cardiovascular disease. Abnormal increases in the fight-or-flight neurotransmitter, norepinephrine, are thought to contribute to the development of hyperarousal, a major symptom of PTSD and facilitator of cardiovascular disease. The overarching goal of our research is to use an animal model of combat-related trauma to identify druggable targets that can improve regulation of hyperarousal. Specifically, these studies will test the hypothesis that an inflammatory molecule signaling within the locus coeruleus, a stress-sensitive brain region, promotes trauma-induced behavioral and cardiovascular risk in males and females.

PI_NAMEs: WOOD, SUSAN KATHLEEN (contact)

PROJECT_TERMS: Acetylcysteine;Address;Afghanistan;Animal Model;Animals;antagonist;Antiinflammatory Effect;antioxidant therapy;Antioxidants;Autonomic Dysfunction;Autopsy;awake;Behavioral;blood pressure elevation;Brain;Brain Diseases;Brain region;Cardiovascular Abnormalities;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cerebrospinal Fluid;Chronic;combat;combat trauma;comorbidity;desensitization;Development;Disinhibition;Down-Regulation;druggable target;Electrophysiology (science);Environment;Equilibrium;Exhibits;Exposure to;FDA approved;Female;fighting;Functional disorder;glial activation;Goals;Heart Rate;heart rate variability;Human;human tissue;Hyperactivity;immune activation;improved;indexing;Individual;Inflammation;Inflammatory;Interleukin-1;Interleukin-1 Receptors;Interleukins;Intervention;Iraq;Knowledge;Link;locus ceruleus structure;male;Measures;Mediating;men;Mental Health;Microglia;military veteran;Modeling;Molecular;Negative Valence;neuromechanism;Neurons;neuroregulation;Neurotransmitters;Norepinephrine;norepinephrine system;Opioid Receptor;Pathology;Patients;Phenotype;Phosphorylation;Post-Traumatic Stress Disorders;post-traumatic symptoms;pre-clinical;Predisposition;Prevalence;psychiatric symptom;Rattus;Reactive Oxygen Species;Receptor Activation;Regulation;Research;Research Project Grants;resilience;response;Risk;Rodent;Role;screening;sex;Signaling Molecule;social;social defeat;Soldier;Source;Stress;stressor;Superoxides;Sympathetic Nervous System;Techniques;Telemetry;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Time;Tissues;Translating;Trauma;traumatic stress;Treatment Efficacy;Veterans;War;Withdrawal;Woman;Work

PROJECT_TITLE: Neural regulation of susceptibility to hyperarousal


ORG_CITY: HANOVER

ORG_DEPT: BIOLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: NARRATIVE Meiosis is a specialized type of cell division that gives rise to eggs and sperm. In humans, errors during meiosis are the leading cause of miscarriages and birth defects such as Down Syndrome. The experiments in this proposal are designed to elucidate the mechanisms that operate during normal meiosis, to understand the defects that give rise to errors during human meiosis, and to test nutritional strategies that may reduce these errors.

PI_NAMEs: BICKEL, SHARON ELIZABETH (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Acetylation;Address;Age;age effect;age related;age-related disease;Aging;aging process;Anaphase;Aneuploidy;arm;Autophagocytosis;Biological Models;candidate identification;Cell Aging;Cell division;cell type;Chromosome Segregation;Chromosomes;cohesion;Complex;Congenital Abnormality;CSPG6 gene;Cytoprotection;Data;Defect;design;Deterioration;dietary supplements;Down's Syndrome;Drosophila genus;egg;Ensure;Enzymes;experience;experimental study;Female;fetal;Future;Genetic;Genetic Nondisjunction;Genetic Screening;Goals;Homeostasis;Homologous Gene;Human;Incidence;Individual;interest;Investigation;knock-down;Laboratories;Link;Lysine;Maintenance;Maternal Age;Mediating;Meiosis;Meiotic Prophase I;Metabolic stress;Modeling;Molecular;Nutritional;nutritional supplementation;older women;Oocytes;Optic Chiasm;Ovary;Ovulation;oxidative damage;Oxidative Stress;Pathology;Pathway interactions;Play;Positioning Attribute;Pregnancy;Pregnancy Outcome;premature;prevent;Process;programs;Prophase;Proteins;Proteomics;Recombinants;Regulation;Rejuvenation;Reproductive Health;RNA Interference;Role;S phase;segregation;SIRT1 gene;Sirtuins;Sister Chromatid;small molecule;sperm cell;Spermidine Synthase;Spontaneous abortion;Superoxides;Testing;Time;Woman;women's outcomes;Work

PROJECT_TITLE: Regulation of Sister-Chromatid Cohesion in Meiosis

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Mild traumatic brain injury (mTBI) is a major public health issue and significant source of disability in the United States. While auditory symptoms are among the most common sequelae of mTBI, the neurobiological mechanisms are not well understood. Rigorous studies of auditory pathophysiology in humans and mice with mTBI could provide a critical step toward addressing two of the most urgent needs in this field: 1) To develop clinical measures in human subjects with mTBI that may eventually evolve into a new class of biomarkers, and 2) To understand the underlying etiology of auditory dysfunction following mTBI in an animal model.

PI_NAMEs: KOZIN, ELLIOTT  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Acute;Address;Anatomy;Animal Model;Anosmia;Area;Auditory;Auditory area;auditory pathway;Auditory Psychophysics;Auditory system;Award;Awareness;Behavioral;Biological Markers;Brain;Brain Concussion;Classification;Clinical;clinical imaging;Coal;Cochlea;Code;common symptom;comparison control;Compensation;Craniocerebral Trauma;Cues;Development;Diagnosis;Diagnostic Procedure;disability;Disease;Dizziness;Electroencephalography;Etiology;Exhibits;experience;extracellular;Frequencies;Functional disorder;Future;Genetic Transcription;Goals;Hearing;hearing impairment;Hearing problem;Hearing Tests;Histopathology;Human;human subject;Hyperactivity;Hyperacusis;Imaging technology;Individual;Inferior Colliculus;Injury;Inner Hair Cells;insight;Link;Liquid substance;Literature;Measurement;Measures;mechanical force;Mentors;Mentorship;Messenger RNA;mild traumatic brain injury;Modality;Modeling;mouse model;Mus;neural;neurobiological mechanism;Neurobiology;neuromechanism;Neurons;Neuropathy;neurophysiology;neurosensory;novel strategies;Pathology;Pathway interactions;Patient observation;Patient Self-Report;Patients;Phenotype;Physiological;Psychophysics;psychosocial outcome;Public Health;Reporting;Research;research clinical testing;response;Scalp structure;Scientist;Sensory;sensory system;Serinus;Severities;Signal Transduction;sound;Source;speech in noise;Speech Intelligibility;Stimulus;stimulus processing;Structure;Symptoms;Synapses;System;Technology;Testing;Time;Tinnitus;Training;Traumatic Brain Injury;United States;Vision

PROJECT_TITLE: Neural Mechanisms Underlying the Auditory Phenotype of Mild Traumatic Brain Injury


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cancer;Nutrition;Prevention

ORG_CITY: BERKELEY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Ferroptosis is a regulated form of lipotoxic cell death that has been implicated in the etiology of degenerative diseases and can be targeted to kill drug-resistant cancer cells. Our research aims to understand the mechanisms that protect cells from lipotoxicity and promote cancer resistance to ferroptosis. Our research will identify new factors that can be targeted for novel chemotherapeutic strategies.

PI_NAMEs: OLZMANN, JAMES A (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Alcohols;Antioxidants;Attention;Biochemistry;Biological Markers;cancer cell;Cancer Model;cancer therapy;cancer type;candidate identification;candidate selection;Cell Death;cell injury;Cells;Cellular biology;Coenzyme Q10;combat;CRISPR screen;Cystine;Cytoplasm;Cytoprotection;Degenerative Disorder;Disease;Drug resistance;efficacious treatment;Etiology;fatty acid metabolism;Fatty Acids;functional genomics;Funding;Generations;Genetic Screening;Glutamates;Glutathione;Goals;Health;improved;In Vitro;in vivo Model;Iron;Isotopes;Knowledge;lipid metabolism;Lipid Peroxidation;Lipid Peroxides;lipidomics;Lipids;lipophilicity;Malignant Neoplasms;Maps;Masks;Mediator;Membrane;Methods;Modeling;Molecular;NADH oxidoreductase;NADP;Nerve Degeneration;Neurodegenerative Disorders;novel;Organelles;oxidative damage;Oxidoreductase;Pathway interactions;Peroxidases;phospholipid-hydroperoxide glutathione peroxidase;Phospholipids;prevent;protective factors;protective pathway;Protein Isoforms;Proteins;Raman Spectrum Analysis;Reactive Oxygen Species;recruit;Regulation;repaired;repository;Research;Resistance;Role;Signal Transduction;System;Testing;Therapeutic;Tumor Suppressor Proteins;whole genome

PROJECT_TITLE: Elucidating the relationship between lipid droplets, lipid metabolism, and lipotoxicity


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The proposed research is focused on understanding the molecular basis of the tumor suppressor activity of wild-type p53 and the oncogenic functions of tumor-derived mutant p53. The long-term goal is to utilize this knowledge to improve diagnosis and design novel targeted therapies for a wide variety of human cancers.

PI_NAMEs: MANFREDI, JAMES J (contact);PRIVES, CAROL

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: Address;Apoptosis;base;Cell Lineage;Cells;Complex;Cytoplasm;design;Diagnosis;DNA Damage;functional restoration;gain of function;Gene Expression;Genes;Genetic Transcription;Goals;Human;improved;in vivo;in vivo Model;insight;Knowledge;Liver;Malignant Neoplasms;Mediating;Molecular;mouse model;mutant;Mutation;neoplastic cell;new therapeutic target;Normal Cell;Oncogenic;Outcome;Radiation Tolerance;Research;Resistance;response;Role;Specificity;Spleen;targeted treatment;Therapeutic;Therapeutic Index;Thymus Gland;Tissue-Specific Gene Expression;Tissues;TP53 gene;Transcriptional Regulation;translational potential;tumor;Tumor Suppression;Tumor Suppressor Proteins;Tumor-Derived;tumorigenesis

PROJECT_TITLE: Cell lineage determinants of p53-driven fate outcomes in vivo

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Cardiovascular;Obesity

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Discrete and diverse Calcium (Ca2+) signals generated at highly specialized junctional spaces either between the plasma membrane and the endoplasmic reticulum (PM-ER) or between the ER-Mitochondria or PM- mitochondria play a crucial in controlling the function of all cells. We study the fundamental mechanisms that regulate the function of molecules that generate these Ca2+ signals and their dysfunction in a number of disease conditions, including vascular diseases and metabolic diseases such as obesity. When dysfunctional, these important Ca2+ signals can abnormally impact on growth, motility, secretion and metabolism of cells. Our aims are to understand the molecular mechanisms of these Ca2+ signals under normal and pathological conditions, so we can determine new ways to modulate these signals through the use of new drugs that can prevent and cure cardiovascular and metabolic disease.

PI_NAMEs: TREBAK, MOHAMED  (contact)

PROJECT_TERMS: Animal Model;Apoptosis;Biochemical;Bioenergetics;Biogenesis;Biophysics;Calcium;Calcium Channel;Calcium Signaling;calcium uniporter;Cardiovascular Diseases;Cell membrane;cell type;Cells;Cellular Metabolic Process;Communication;Coupling;Data;Disease;Endoplasmic Reticulum;endothelial dysfunction;Family;Family member;Functional disorder;Genes;Growth;Health;human disease;human model;Hypertension;In Vitro;in vivo;insight;Mediating;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;migration;Mitochondria;Mitochondrial Matrix;mitochondrial membrane;Molecular;Motility;novel;novel therapeutics;Obesity;Pathologic;Physiological;Physiology;Play;prevent;Proliferating;Proteins;Receptor Activation;Regulation;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;STIM1 gene;System;uptake;Variant;Vascular Diseases;Vascular remodeling;virtual

PROJECT_TITLE: Ca2+ signaling Networks in Health and Disease


NIH_SPENDING_CATS: Chronic Pain;Dental, Oral, and Craniofacial Disease;Neurosciences;Pain Research

ORG_CITY: ANN ARBOR

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Dr. Joshua Emrick will use mouse models to determine how tooth-innervating neurons contribute to normal dental sensation and how this input is transformed to elicit dental pain during inflammation. Toothache is one of the most common forms of orofacial pain. Deciphering how sensation from the teeth normally controls behavior and is transformed by inflammation to trigger intense pain should expose pain mechanisms as well as new approaches for pain relief.

PI_NAMEs: EMRICK, JOSHUA JAMES (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: addiction;Address;Adult;Afferent Neurons;Assessment tool;Behavior;Behavior Control;behavioral response;Biological Assay;calcium indicator;Calibration;career development;Categories;clinical pain;Dedications;Dental;Dental Pulp;Dentists;Dentition;Dependence;Development;Diameter;Disease;effective therapy;Epidemic;Esthesia;Exposure to;Face;feature detection;Functional Imaging;Goals;Health;imaging platform;in vivo;in vivo calcium imaging;Inflammation;Injury;intense pain;Ion Channel;Knowledge;Label;Link;Machine Learning;Mechanics;Medical;Mentors;Modeling;Molar tooth;Molecular;Monitor;mortality;mouse model;Mus;nerve supply;Neurons;Nociception;Nociceptors;non-opioid analgesic;novel strategies;novel therapeutics;Opioid Analgesics;optogenetics;orofacial;Orofacial Pain;Osmosis;Pain;Pain management;pain relief;Perception;Peripheral;Phase;Physiological;Population;prescription opioid;Prevalence;prevent;Quality of life;Reporter;Research;response;Role;Scientist;Sensory;sensory input;sensory mechanism;sensory stimulus;Signal Transduction;somatosensory;Stimulus;Structure;Structure of trigeminal ganglion;Surveys;System;Testing;Tooth structure;Toothache;Touch sensation;Training;transcriptomic profiling;transcriptomics;Trigeminal System;Work

PROJECT_TITLE: Determining the functions of tooth-innervating neurons in dental sensation

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ORG_CITY: MEMPHIS

ORG_NAME: MEMPHIS VA MEDICAL CENTER

ORG_STATE: TN

PHR: Alcohol misuse is widespread among military personnel and Veterans. Alcohol misuse occurs among a substantial number of Veterans exposed to combat-related traumatic stress. Therefore, stress is comorbid with alcohol misuse. There is an intimate relationship between post-traumatic stress disorder (PTSD) and alcohol- associated disorders (AAD). PTSD is involved in causing AAD, and together they make both conditions worse and hard to treat. Understanding the relationships between stress and alcohol misuse and the mechanisms that underlie compounding injury by stress and alcohol is clinically significant for Veterans’ health. We propose to conduct studies to uncover the cellular and molecular mechanisms involved in stress and alcohol-induced gut permeability, alteration of gut microbiota, endotoxemia, systemic inflammation, and multiple organ damage. The outcome of these studies will identify gut microbiota and the antibacterial peptides (defensins) as common therapeutic targets developing treatment strategies for PTSD and AAD.

PI_NAMEs: RAO, RADHAKRISHNA  (contact)

PROJECT_TERMS: Alcohol consumption;alcohol misuse;Alcoholic beverage heavy drinker;Alcohols;alpha-Defensins;Anti-Bacterial Agents;Attenuated;Behavior Therapy;Brain;Cell secretion;Cellular biology;Chronic;Chronic stress;Clinical;clinically significant;combat;comorbidity;Corticosterone;Defensins;Disease;Down-Regulation;dysbiosis;Endotoxemia;Ethanol;experience;Exposure to;fecal transplantation;Feedback;Functional disorder;global health;Glucocorticoid Receptor;Glucocorticoids;Goals;gut dysbiosis;gut microbiota;Health;host microbiome;Human;In Vitro;in vivo Model;Injury;insect defensin A;intestinal epithelium;Intestinal permeability;Intestines;Knock-out;knockout gene;Knockout Mice;Link;Liver;liver injury;Mediating;Messenger RNA;microbiota;microbiota composition;Microinjections;Military Personnel;military veteran;Molecular;Mucositis;multiorgan injury;Mus;neuroinflammation;novel;novel therapeutic intervention;NR3C1 gene;Organ;Outcome;Outcome Study;Paneth Cells;pathobiont;Patients;Peptides;Post-Traumatic Stress Disorders;prevent;Preventive;Production;Proteomics;Qualifying;receptor;Recovery;Regulation;Reporter;Research;response;restraint stress;Role;Stress;stress disorder;Symptoms;systemic inflammatory response;T-Cell Receptor;Therapeutic;therapeutic target;tissue injury;transcription factor;traumatic stress;treatment strategy;Veterans;young man

PROJECT_TITLE: Impact of Stress on Alcohol-Associated Gut Injury and Systemic Response


NIH_SPENDING_CATS: Hearing Loss;Neurosciences

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Hearing at birth, as well as lifelong hearing preservation, requires sensory cells in the inner ear to develop and maintain a motion-sensing compartment that detects sound-borne vibrations. This project seeks to understand how this compartment acquires its unique slanted architecture required for sensory function, and how this architecture is preserved during life despite wear and tear. Accomplishment of the proposed research will help the interpretation and design of treatments for auditory dysfunction.

PI_NAMEs: TARCHINI, BASILE ROBIN (contact)

PROJECT_TERMS: Acceleration;Actins;Address;Adult;Affect;Apical;apical membrane;Architecture;Auditory;Binding;Biochemical;Biological Assay;Birth;Cell Culture Techniques;Cell Differentiation process;Cell membrane;Cells;Chemicals;Cochlea;Complex;congenital hearing loss;Cues;Cytoskeleton;Data;deafness;Defect;Development;Dimensions;Epidermal Growth Factor Receptor Pathway Substrate 8;Epithelium;Etiology;Failure;Fluorescence Recovery After Photobleaching;Functional disorder;Functional Regeneration;Generations;Genes;Genetic;GPSM2 gene;GTP Binding;GTP-Binding Protein Regulators;GTP-Binding Proteins;GTPase-Activating Proteins;Guanine;Guanine Nucleotide Exchange Factors;Guanine Nucleotides;Guanosine Triphosphate;Hair;Hair Cells;Hearing;hearing impairment;hearing preservation;Hearing problem;Height;Hydrolysis;in vivo;Individual;inducible Cre;Injections;Intercellular Junctions;Investigation;Knock-in Mouse;Knowledge;Label;Labyrinth;Lateral;Life;Maintenance;mechanical stimulus;Membrane;Mitotic spindle;Molecular;Monitor;Morphogenesis;Motion;Motor;mouse model;Mouse Strains;Mus;Myosin ATPase;Operative Surgical Procedures;Physiologic pulse;Point Mutation;polarized cell;polymerization;Polymers;Predisposition;preservation;protein complex;Protein Dynamics;protein function;Proteins;public health relevance;repaired;Reporter;Research;Role;Scaffolding Protein;Sensorineural Hearing Loss;Sensory;Sensory Hair;Shapes;Side;Signal Transduction;small molecule inhibitor;sound;Structure;Syndrome;Tamoxifen;Technology;temporal measurement;Testing;therapy design;Time;trafficking;vibration;Visualization;WHRN gene;Work

PROJECT_TITLE: Hair Cell Polarization and Sensory Bundle Development


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Glaucoma is the most common cause of irreversible blindness and about half of the patients have normal tension glaucoma that are in urgent need for effective neuroprotective treatment. The proposed experiments will reveal the neuron-intrinsic molecular mechanisms of optineurin, a normal tension glaucoma-causing gene, in neuronal survival and degeneration. The experiments have the potential to identify the key optineurin-interacting genes that mediate its function in neurons, which are potential novel therapeutic targets for neural repair.

PI_NAMEs: HU, YANG  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Amyotrophic Lateral Sclerosis;Animal Model;Autophagocytosis;Axon;axonal degeneration;Axonal Transport;axonopathy;Biochemical;Biological Assay;Biotin;Blindness;causal variant;cDNA Library;Cell Death;Collaborations;Cytokine Signaling;Data;Environment;experimental study;Failure;Functional disorder;gene function;gene interaction;Gene Mutation;Genes;Glaucoma;Goals;Histologic;Human;Hybrids;Image;Impairment;in vivo;Inherited;Intervention;Link;Mediating;Mitochondria;Modeling;Molecular;Monitor;Morphology;mouse model;Mus;mutant;Mutation;Nerve Degeneration;neural repair;neuronal survival;Neurons;neuroprotection;new therapeutic target;novel;Ocular Hypertension;Optic Nerve;optic nerve disorder;overexpression;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Physiologic Intraocular Pressure;Play;Population;Positioning Attribute;Proteins;receptor;Retina;Retinal Ganglion Cells;Role;Scientist;Structure;syntaphilin;Testing;Therapeutic;Time;tool;trafficking;Transgenic Mice;Vacuum;Vesicle;Yeasts

PROJECT_TITLE: Optineurin dysfunction induces neurodegeneration in normal tension glaucoma by a novel molecular mechanism

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Our ability to distinguish our own vocal sounds (vocal feedback) from other sounds is essential to communication and hearing during speech. Vocal motor-related signals that suppress auditory responses to predictable vocal feedback are thought to underlie this ability, but the neural mechanisms mediating this suppression are unknown. This proposal combines the advanced genetic and physiological toolkit in the mouse with an innovative method to distort vocal feedback to elucidate these neural mechanisms.

PI_NAMEs: HARMON, THOMAS CURTIS (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acoustics;Affect;Air;Arousal;Auditory;Auditory area;Auditory Hallucination;Auditory system;Behavioral;Communication;congenital deafness;Courtship;Detection;Disease;Dissociation;excitatory neuron;experimental study;extracellular;Feedback;Frequencies;Functional disorder;Genetic;genetic approach;Genetic Techniques;Head;Hearing;Helium;hippocampal pyramidal neuron;Human;Image;in vivo;inhibitory neuron;innovation;Interneurons;Locomotion;male;Measures;Mediating;Methods;Monitor;Monkeys;Motor;multiphoton imaging;Mus;Nervous System;neural;neural circuit;neuromechanism;Neurons;non-verbal;novel;Organism;Perception;Personal Satisfaction;Physiological;Population;Process;Production;Resolution;response;Schizophrenia;Shapes;Signal Transduction;social communication;Social Interaction;Social isolation;sound;Specificity;Speech;Stimulus;Testing;two-photon;vocal learning;vocalization;Voice

PROJECT_TITLE: Circuit dynamics of predictive vocal suppression in auditory cortex


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative Heart disease is responsible for over 600,000 deaths annually, making it the number one killer of women and men in the United States. There are currently no small diameter vascular grafts that effectively treat this disease. This proposal seeks to use computational tools to fabricate a fully biodegradable small diameter vascular tissue engineered graft that is and remains compliance matched as it remodels in-vivo.

PI_NAMEs: VANDE GEEST, JONATHAN PIETER (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Acute;Adult;Animal Model;Animals;Anti-Inflammatory Agents;Aorta;Autologous;Bilateral;Biopolymers;Blood Vessels;Bypass;calponin;Cd68;Cells;Cessation of life;Characteristics;Clinical;Clinical Treatment;Collagen;Computer Simulation;computerized tools;controlled release;Coronary Artery Bypass;Coronary heart disease;cost efficient;Deposition;design;Development;Diameter;Disease;Elements;Endothelium;Environment;Exhibits;Extracellular Matrix;Failure;Gelatin;graft failure;Heart Diseases;hemodynamics;Hyperplasia;Implant;implantation;improved;In Vitro;in vivo;in vivo Model;Individual;Infiltration;Legal patent;Macrophage;Maintenance;mechanical properties;Mechanics;men;Modeling;Myosin Heavy Chains;novel;Organ Transplantation;Performance;Phenotype;Play;pre-clinical;pre-clinical assessment;preimplantation;Process;Production;Rattus;recruit;Reporting;Research;Research Project Grants;response;Role;Saphenous Vein;Sheep;Site;Smooth Muscle Myocytes;Sprague-Dawley Rats;Testing;thrombogenesis;Thrombosis;Tissue Engineering;Transforming Growth Factor Beta 2;translational potential;Tropoelastin;United States;Vascular Diseases;Vascular Graft;Vascular Smooth Muscle;vascular tissue engineering;Woman;Work

PROJECT_TITLE: Preclinical Assessment of a Compliance Matched Biopolymer Vascular Graft

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: AG

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Rural Health;Social Determinants of Health

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE This project addresses the place-based causes of the rise in midlife mortality in the U.S. It makes use of highly detailed mortality records, often at the scale of the residential block. It will analyze the characteristics of places in the context of where they are located and how social and economic conditions have changed, and suggest potential policy interventions to reduce future mortality.

PI_NAMEs: GUTMANN, MYRON P. (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Address;Adult;Affect;Age;aged;Alcohol abuse;Algorithms;Area;Attention;Businesses;Cardiometabolic Disease;Cause of Death;Censuses;Cessation of life;Characteristics;Child;Classification;Communicable Diseases;Communities;Complex;County;COVID-19;Crime;Data;Databases;Demographic Analyses;design;Detection;detection method;Development;Differential Mortality;Distress;Drug abuse;Economic Conditions;Economics;Employment;Event;experience;Feedback;Foreclosure;Formulation;Future;Geography;Health Policy;Hepatitis C;Housing;Income;Individual;Inequality;innovation;Intervention;Maps;Methods;middle age;Modeling;mortality;Mortality Determinants;mortality risk;novel;Outcome;Pattern;Policies;Policy Developments;policy recommendation;Policy Research;Population;Population Sizes;Procedures;Process;Property;Records;Research;Research Personnel;Resolution;response;Risk;Risk Factors;Role;Rural;Rural Health;Science;Series;Social Conditions;social disparities;spatiotemporal;Spottings;Statistical Data Interpretation;statistics;Structure;suicide rate;Testing;theories;therapy design;Time;trend;trend analysis;Work

PROJECT_TITLE: Addressing the Midlife Mortality Crisis: Place-Based Modeling, Trend Analysis and Policy Interventions


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Fractures, in particular poorly healing fractures, are a major cause of morbidity, lost productivity, and mortality in the Veteran population. Means of accelerating fracture repair are few, but parathyroid hormone and its more effective analog abaloparatide show promise. In long bones there are 3 distinctly different sites of fracture repair: intramembranous along the periosteum, endochondral within the bridge region between the fracture ends, and intramedullary within the marrow at the site of fracture. These involve different cells and likely different molecular events. The PTH/PTHrP receptor through which abaloparatide acts is expressed in the different cells involved with fracture repair and so is expected to affect all sites and processes. This project will determine the effectiveness of abaloparatide in fracture repair, examine the cellular and molecular mechanisms by which abaloparatide promotes fracture repair at the different sites, and explore the role of IGF1 and ephrinB2/EphB4 signaling in mediating these actions of abaloparatide.

PI_NAMEs: BIKLE, DANIEL DAVID (contact)

PROJECT_TERMS: Acceleration;Affect;Anabolic Agents;analog;bone;Bone callus;bone fracture repair;Bone Marrow;cantilever;Cells;Characteristics;Chondrocytes;Complex;cortical bone;Cortical vasculature;Coupling;directed differentiation;disease model;effectiveness evaluation;Ephrin-B2;Event;Finite Element Analysis;Fracture;Genomics;IGF1 gene;Image;in vitro Model;in vivo;Injury;intramembranous bone formation;Invaded;Laboratories;long bone;Marrow;Measures;Mechanics;Mediating;Messenger RNA;Methods;migration;military veteran;Minerals;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;novel;Osteoblasts;osteochondral tissue;Osteocytes;Osteogenesis;osteoprogenitor cell;Outcome Measure;Parathyroid Hormone Receptor;parathyroid hormone-related protein;Pathway interactions;Pericytes;Periosteum;Population;Pre-Clinical Model;Process;Productivity;progenitor;Proliferating;PTH gene;receptor;regenerative;repaired;Research;response;Role;Signal Transduction;Site;stem cell biomarkers;stem cells;Structure;Surface;Testing;tomography;transcriptome sequencing;transcriptomics;transdifferentiation;Veterans;X-Ray Computed Tomography

PROJECT_TITLE: BCCMA:Foundational Research to Act Upon and Resist Conditions unfavorable to bone (FRACTURECURB):Role of abaloparatide for fracture healing


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cervical Cancer;Genetics;Human Genome;Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: TUCSON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative The proposed work has relevance towards understanding the interplay between prevalent cancer-causing human papillomaviruses (HPVs) and the host cell shortly after infection. From this work we will understand how HPV regulates alternative splicing to allow for establishment and long-term persistence, the risk factor for HPV- associated cancers.

PI_NAMEs: VAN DOORSLAER, KOENRAAD  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Address;Adenosine;Alternative Splicing;Antineoplastic Agents;Basic Science;Biology;Cell Differentiation process;Cell Physiology;Cells;Cervical;chronic infection;cis acting element;Clinical Trials;Complex;Data;Deposition;DNA Damage;drug development;druggable target;Environment;Enzymes;Epithelium;Event;Exclusion;Exons;Future;Gene Expression;Genetic Transcription;Genome;Genomic approach;Head and Neck Cancer;histone methylation;Human;Human papilloma virus infection;human papilloma virus oncogene;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 18;Incidence;Infection;inhibitor;Introns;keratinocyte differentiation;Knowledge;Life Cycle Stages;Link;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Messenger RNA;Methylation;Methyltransferase;Modification;Molecular Target;novel therapeutics;Papillomavirus;Pattern;Phase;Phenotype;Play;Polyadenylation;Positioning Attribute;pre-clinical;Protein Inhibition;Protein-Arginine N-Methyltransferase;Proteins;recruit;Regulation;response;Risk Factors;RNA Splicing;Role;Sexually Transmitted Diseases;single cell genomics;Site;Site-Directed Mutagenesis;Technology;Testing;Tissues;Transcript;tumor;Viral;viral DNA;Viral Gene Expression Regulation;Viral Genes;Viral Genome;Viral Proteins;viral RNA;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Cis-acting Elements in the Regulation of Papillomavirus Gene Expression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-S(02)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: BALTIMORE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Many antibiotics inhibit protein synthesis in bacteria by interfering with the function of ribosomes. The proposed studies will increase our understanding of how bacterial cells sense that problems have occurred during protein synthesis and will reveal the mechanisms by which they resolve these problems.

PI_NAMEs: BUSKIRK, ALLEN ROWDON (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Antibiotics;Bacteria;Binding;Biochemical;Biological Assay;Cells;Chemicals;Codon Nucleotides;Collaborations;Complex;Consensus;Cryoelectron Microscopy;Cues;Data;dimer;endonuclease;Escherichia coli;Eukaryota;Event;experimental study;Failure;feature detection;Genetic Screening;genetic selection;genome-wide;Goals;in vivo;insight;interest;Kinetics;Mass Spectrum Analysis;Messenger RNA;Methods;Molecular;novel;nuclease;Open Reading Frames;Output;Pathogenesis;Pathway interactions;Predisposition;Productivity;Protein Biosynthesis;Protein Synthesis Inhibition;Proteins;Qualifying;Quality Control;Reaction;Reporter;Research Personnel;Resistance;Resolution;Ribosomal RNA;ribosome profiling;Ribosomes;Role;Signal Transduction;single-molecule FRET;Site;Structure;Testing;Theoretical model;tmRNA;Transcript;transcriptome sequencing;Transfer RNA;Translating;Translations;Ubiquitin;ubiquitin-protein ligase;Work;Yeasts

PROJECT_TITLE: The role of collisions in rescuing stalled ribosomes in bacteria

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: MILWAUKEE

ORG_DEPT: BIOPHYSICS

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Electron paramagnetic resonance (EPR) spectroscopy is a critically important technique in biomedical research with a unique ability to detect naturally occurring or engineered unpaired electrons in complex biological environments. We will develop two innovative EPR spectrometer technologies with outstanding sample sensitivity that are easy to use and widely available to the scientific community. The resulting state-of-the-art prototypes will provide a transformative increase in throughput that will enable a wide range of new applications in biomedical EPR spectroscopy studies including structural biology, metalloprotein research, redox biology, rational drug design, and clinical diagnostics for a range of disease areas.

PI_NAMEs: KLUG, CANDICE S (contact);LERCH, MICHAEL TAYLOR

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Area;Automobile Driving;Biological;Biological Models;Biology;Biomedical Research;Biomedical Technology;biophysical techniques;clinical diagnostics;Collection;Communities;Complex;data acquisition;Data Collection;design;Development;Disease;Drug Design;drug discovery;Electromagnetic Fields;Electron Spin Resonance Spectroscopy;Electrons;Engineering;Environment;Enzymes;Equipment;Frequencies;Geometry;Goals;improved;innovation;instrument;instrumentation;Intervention;Kinetics;magnetic field;Magnetism;Measurement;Membrane;Metalloproteins;millisecond;Muramidase;nano;new technology;novel;Oxidation-Reduction;Performance;Positioning Attribute;Protein Conformation;Protein Dynamics;protein structure;prototype;Reaction;Research;Sample Size;Sampling;Science;Signal Transduction;simulation;structural biology;Structure;System;Techniques;Technology;Temperature;Testing;theories;Time;Tube

PROJECT_TITLE: Development of high-throughput, high-sensitivity EPR sample handling capabilities for biomedical research

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The aim of the proposed program is to train postdoctoral fellows in translational immunology research. The program will offer mentored research opportunities in six different but interconnected subspecialties: basic immunology, developmental immunology, immunity to pathogens, tumor immunology, transplantation immunology and autoimmunity. The ultimate goal is to provide trainees with the necessary competence to become future leaders in the field of immunology.

PI_NAMEs: SYKES, MEGAN  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Training in Translational Immunology Research

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Chromosome translocations involving mixed lineage leukemia (MLL) gene cause acute leukemia with a particularly poor prognosis. The objective of this project is to use a combination of rational inhibitor design, medicinal chemistry, biochemical and biophysical studies, and biological activity testing to develop the first, drug-like inhibitors of human transcription cofactor protein AF9/ENL, which play critical roles in oncogenic expression in MLL-rearranged leukemia.

PI_NAMEs: SONG, YONGCHENG  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Acute;Acute leukemia;Acute Myelocytic Leukemia;Adolescent;Adult;AF-9 protein;Animals;Apoptosis;assay development;Binding;Biochemical;Biological;Biological Assay;Biological Testing;biophysical analysis;Bone Marrow;Bone Marrow Cells;C-terminal;CDK9 Protein Kinase;Cell Proliferation;Cells;Chemicals;Child;Childhood;Childhood Leukemia;chromatin immunoprecipitation;Chromosomal translocation;Clinical;cofactor;Complex;Consensus Sequence;conventional therapy;cyclin T1;cytotoxicity;design;drug candidate;Drug Kinetics;Drug Targeting;Evaluation;Event;Exhibits;Fusion Oncogene Proteins;Gene Expression;Genes;genetic signature;Genetic Transcription;high throughput screening;Human;Immunomodulators;Immunoprecipitation;improved;In Vitro;in vivo;Infant;inhibitor;leukemia;leukemia initiating cell;Leukemic Cell;leukemic transformation;Lymphoblastic Leukemia;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;Methylation;Methyltransferase;mixed lineage leukemia cell;Mixed-Lineage Leukemia;MLL gene;MLLT2 gene;MLLT3 gene;Molecular Biology;mouse model;Mutagenesis;Myelogenous;Myeloid Leukemia;N-terminal;Neonatal Leukemia;Normal Cell;novel;Oncogenes;Oncogenic;Organ;Outcome;paralogous gene;Patients;pediatric acute leukemia;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phosphorylation;Play;Polymerase;Positive Transcriptional Elongation Factor B;Prognosis;programs;Proliferating;protein protein interaction;Proteins;rational design;recruit;response;RNA Polymerase II;Roentgen Rays;Role;Sampling;screening;Second Primary Cancers;side effect;small molecule;small molecule inhibitor;stem cells;Structure-Activity Relationship;Testing;Therapeutic;Toxic effect;Transcription Elongation;transcription factor;tumor;tumorigenesis;Validation;X-Ray Crystallography

PROJECT_TITLE: Novel Small-Molecule Probes Targeting Oncogenic Fusion MLL in Pediatric Leukemia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(55)R]


NIH_SPENDING_CATS: Autoimmune Disease;Infectious Diseases;Lupus;Microbiome;Urologic Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PUBLIC RELEVANCE  This project aims to establish a model of recurrent/chronic urinary tract infections (UTIs) in lupus prone mice that experts in SLE can use to study the role of bacterial mucosal infections in the pathogenesis of autoimmune diseases. The project will generate a tool to test novel therapeutic approaches in lupus through the control of subacute infections and the re-establishment of the correct urinary microbiome. This goal is especially important in women living with SLE, in which subclinical UTIs is associated to flare and disease.

PI_NAMEs: GALLUCCI, STEFANIA  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Abscess;Acceleration;adaptive immune response;Affect;Amyloid;anti-dsDNA antibodies;Antibodies;Autoantibodies;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;Bacteria;Bacterial DNA;Bacterial Infections;Bacteriuria;Bladder;cell community;Cells;Chromatin;Chronic;Clinical;cohort;Collaborations;Complex;cytokine;Development;Disease;DNA;ds-DNA;Endotoxins;epidemiology study;Escherichia coli;Experimental Models;Exposure to;Flare;genetic makeup;Genetic Predisposition to Disease;Goals;Gram-Negative Bacteria;Human;Immune;Immune response;immune self tolerance;Immune system;Individual;Infection;infection rate;Inflammatory;inflammatory marker;Innate Immune Response;Interferon Type I;intraperitoneal;Link;Literature;Lupus;lupus prone mice;Mediating;Microbial Biofilms;microbial products;microbiome;Modeling;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Mus;mutant;novel therapeutic intervention;pathogen;Pathogenesis;Patients;Pneumonia;Population;Predisposition;Production;Protocols documentation;Publishing;Recurrence;Reporting;Role;Sepsis;Serum;Severities;soft tissue;Stimulus;Systemic Lupus Erythematosus;Testing;Therapeutic immunosuppression;TLR2 gene;tool;translational study;Urinary Microbiome;Urinary tract infection;Uropathogenic E. coli;Woman;women patients

PROJECT_TITLE: Establishing a model of recurrent/chronic urinary tract infection in lupus-prone mice

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


PHR: PROJECT NARRATIVE Salt-sensitive hypertension is a significant health problem worldwide, and a primary modifiable risk factor for renal, cardiovascular, and cerebrovascular diseases. Yet, the underlying mechanisms remain poorly understood, and the current treatments are not very effective. The present studies determine how high salt diets with associated hypertension produce oxidative stress leading to reduced efficiency of mitochondrial oxygen utilization for energy production and progressive failure of the kidney.

PI_NAMEs: COWLEY, ALLEN W (contact);DASH, RANJAN K

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: absorption;Adult;Affect;African American;Apical;Applications Grants;Asian;ATP Synthesis Pathway;Bioenergetics;Blood Pressure;blood pressure reduction;Blood Vessels;Cardiovascular Diseases;Cell membrane;Cell Physiology;Cells;Cerebrovascular Disorders;Complex;Computer Analysis;Computer Models;Consumption;Dahl Hypertensive Rats;Data;Development;Diet;Disease;effective therapy;Environmental Risk Factor;Event;Excretory function;Exhibits;experimental analysis;experimental study;feeding;Foundations;Genetic;Genetic Engineering;Grant;Health;Heart;high salt diet;Human;Hydrogen Peroxide;Hypertension;hypertensive;Injury to Kidney;Kidney;Kidney Diseases;Kidney Failure;Knock-out;Laboratories;Limb structure;Measurement;Measures;Membrane;Membrane Potentials;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;mitochondrial metabolism;Mitochondrial Proteins;Modeling;modifiable risk;Molecular;Morbidity - disease rate;mortality;NADH;NADPH Oxidase;novel;Oxidation-Reduction;Oxidative Phosphorylation;Oxidative Stress;Oxygen;Pathologic;Patients;Play;Population;Process;Production;Publishing;Rattus;Reactive Oxygen Species;Resistance;Respiration;response;Risk Factors;Role;salt intake;salt sensitive;salt sensitive hypertension;Signal Transduction;Sodium Chloride;sodium-potassium chloride cotransporter 2 protein;Source;Testing;Thick;Time;tissue injury;Tubular formation;uptake

PROJECT_TITLE: Experimental and computational analysis of mechanisms of mitochondrial-cellular ROS crosstalk in the kidney in salt-sensitive hypertension

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;Contraception/Reproduction;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Pregnancy is often described as a physiologic “stress test,” with some pregnancy-related cardiac and lipid changes persisting for years after delivery. In older women, higher parity is associated with greater risk of cardiovascular disease and death. However, little is known about whether these pregnancy-related adaptations contribute to higher cardiovascular risk across the lifespan. This study will leverage a unique longitudinal cohort of African-American and white women in their forties to evaluate how pregnancy and parity influence midlife cardiovascular risk.

PI_NAMEs: URBINA, ELAINE MOTT;WOO, JESSICA G (contact);WOOLLETT, LAURA A

PROGRAM_OFFICER_NAME: JAQUISH, CASHELL E

PROJECT_TERMS: African American;Age;Angiotensins;Apolipoproteins;arterial stiffness;Atherosclerosis;Birth;blood lipid;Blood Vessels;Blood Volume;Body Weight;Cardiac;Cardiac Output;cardiometabolism;Cardiovascular alteration;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular imaging;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cessation of life;cohort;Data;Development;Diabetes Mellitus;disparities in women;Echocardiography;Endocrine Physiology;Endothelium;Enrollment;Evaluation;Event;experience;Exposure to;Fetal Development;follow-up;Generations;girls;Growth;Health;heart function;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Hormonal;Hypertension;indexing;insulin sensitivity/resistance;Intervention;Left Ventricular Mass;Life;life span;Link;Lipids;Lipoproteins;Live Birth;Longitudinal cohort;Low Density Lipoprotein oxidation;Menopause;middle age;Myocardial dysfunction;National Heart, Lung, and Blood Institute;Nulliparity;Obesity;Obesity Epidemic;older women;Onset of illness;parity;Participant;particle;Particle Size;Pathway interactions;Perimenopause;Peripheral;Persons;Physiological;post pregnancy;Postmenopause;Postpartum Period;pre-clinical;Pregnancy;Premenopause;Prevalence;prospective;Proteins;Questionnaires;racial disparity;Relaxation;Reporting;reproductive;reproductive development;Reproductive History;Research;Risk;Risk Factors;Sampling;Socioeconomic Status;Stress Tests;Structure;Testing;Vascular Diseases;Vascular resistance;Ventricular;Visceral;Visit;White Women;Woman;Women's Health;Women's study

PROJECT_TITLE: Effect of reproductive history on longitudinal change in cardiac, vascular and lipid parameters

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: Dry eye disease is a highly prevalent inflammatory disorder of the ocular surface. Associated with visual dysfunction, discomfort, and a heightened risk of corneal scarring and ulceration, the immunopathogenic mechanisms of this common condition are as of yet incompletely understood. We propose to determine the specific immune-based cellular and molecular pathogenic elements of dry eye disease, anticipating that improved understanding of these pathogenic mechanisms will yield therapeutic targets that could be useful in optimizing the management of the millions of Americans suffering from dry eye disease.

PI_NAMEs: DANA, REZA  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Adult;Age;Age related macular degeneration;aged;Aging;American;Antigen-Presenting Cells;Blindness;Caring;Cell Physiology;Cells;Chronic;corneal scar;Corneal Ulcer;cytokine;Data;Desiccation;Development;Diagnosis;Direct Costs;Disease;Dose;Dry Eye Syndromes;effective therapy;Elements;Epithelium;experimental study;Exposure to;Eye;Financial Hardship;Functional disorder;functional restoration;Generations;GFI1 gene;Healthcare Systems;High Prevalence;Homeostasis;Homing;IL17 gene;IL7 gene;Immune;Immunity;Immunologic Memory;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;insight;Interferon Type II;Interleukin-2;interleukin-23;Knockout Mice;Knowledge;Laboratories;Maintenance;Mediating;Memory;Molecular;Mus;novel;ocular surface;ocular surface disease;old mice;Pathogenicity;Patients;Phenotype;Predisposition;Prevalence;Principal Investigator;Process;productivity loss;promoter;Regulation;Regulatory T-Lymphocyte;Research;response;restoration;Risk;Series;Severities;Severity of illness;Source;Stress;Substance P;therapeutic target;trafficking;transcription factor;translational impact;Visit;visual dysfunction;Work

PROJECT_TITLE: Immunopathogenic mechanisms of dry eye disease


NIH_SPENDING_CATS: Cancer;Genetics;Skin Cancer

ORG_CITY: STANFORD

ORG_DEPT: DERMATOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: REGULATORS OF EPIDERAL GENE EXPRESSION  Project Narrative The control of gene expression determines the health or disease of human tissues, including skin. Systematic definition of the regulatory DNA motif combinations in homeostasis and early cancer progression is designed to provide information to advance human health for skin and other tissues. 1

PI_NAMEs: KHAVARI, PAUL  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Acceleration;Affect;Alleles;ATAC-seq;Atopic Dermatitis;Binding;Biological Assay;Biological Process;Cells;Data;Dependovirus;design;Differentiated Gene;Diploidy;Disease;Disease Progression;DNA;DNA Binding;DNA Sequence;Enhancers;Epidermis;Future;Gene Activation;Gene Expression;Gene Expression Regulation;gene induction;gene-editing approach;Generations;Genes;Genetic;genome wide association study;Genomics;Goals;Health;Homeostasis;Human;human disease;human tissue;Hybrids;Ichthyoses;in vivo;keratinocyte;keratinocyte differentiation;Kinetics;Knock-in;Link;Logic;Machine Learning;Malignant Neoplasms;Maps;Methods;Mus;Natural regeneration;Nature;Neoplasms;neural network algorithm;Pathogenesis;Pathogenicity;Pattern;Physiological;Prevention;promoter;Proteins;Psoriasis;recruit;Recurrence;Reporter;Risk;Role;Single Nucleotide Polymorphism;Skin;skin barrier;skin disorder;skin squamous cell carcinoma;Skin Tissue;Squamous cell carcinoma;Testing;Tissue Engineering;Tissues;transcription factor;tumor progression;Variant

PROJECT_TITLE: REGULATORS OF EPIDERMAL GENE EXPRESSION

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Autoimmune Disease;Lupus

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Evidence clearly indicates that the peptide/histidine transporter SLC15A4 is required for pathogenic Toll-like receptor responses in systemic lupus erythematosus. Recent studies, however, suggest that SLC15A4 may act not as a transporter but by binding TASL, which then promotes Toll-like receptor responses. Here we propose studies using a novel TASL-deficient mouse model to clarify the mechanisms by which SLC15A4 and TASL promote pathogenic Toll- like receptor responses in systemic autoimmunity with significant implications for the development of new therapeutic approaches.

PI_NAMEs: BACCALA, ROBERTO G (contact)

PROJECT_TERMS: Address;Affect;Antigen-Antibody Complex;Autoantibodies;Autoimmune Diseases;B-Lymphocytes;Binding;Complex;congenic;Data;Dendritic Cells;Development;Disease;druggable target;Event;Family;Genes;genetic signature;Histidine;Human;Impairment;In Vitro;in vivo;Inflammatory;Inflammatory Response;inhibitor;innate immune pathways;Interferon Type I;Interferons;Laboratories;Ligands;Lupus;lupus-like;Mediating;member;mouse model;Mus;Mutation;novel;novel therapeutic intervention;Nucleic Acids;Organ;Pathogenesis;Pathogenicity;Peptides;pharmacologic;Production;Receptor Activation;Receptor Signaling;recruit;response;Role;Signal Transduction;solute;systemic autoimmunity;Systemic Lupus Erythematosus;T-Lymphocyte;therapeutically effective;TLR7 gene;Toll-like receptors;tool;Transformed Cell Line

PROJECT_TITLE: Differential role of TASL and SLC15A4 in TLR responses to nucleic acids and lupus development


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Bacterial pathogens secrete effector proteins that modulate host cell physiology and enable the bacterial invader to escape immune detection and proliferate. One class of effectors re-wire our epigenetic signaling pathways by directly modifying histone proteins, but it is not known if these bacterial effectors can also be regulated by existing histone modifications in the human host. We will use the L. pneumophila effector RomA as a model to establish if pathogenic bacteria can interact with and interpret existing histone modifications through crosstalk mechanisms.

PI_NAMEs: WORDEN, EVAN J (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Affinity;Amino Acids;Ankyrin Repeat;Architecture;Binding;Binding Proteins;Biochemical;Bypass;Catalysis;Cell Nucleus;Cell Physiology;Cell secretion;Cells;Chromatin;chromatin modification;Code;Complex;Complex Mixtures;Cryoelectron Microscopy;Cytoplasm;density;Deposition;Detection;DNA;Environment;Enzyme Interaction;Enzymes;Epigenetic Process;epigenome;Eukaryota;experimental study;Foundations;Freezing;Future;Gene Expression;gene repression;Genes;Genetic Transcription;Genome;Goals;Histone Code;Histone H3;histone methylation;histone modification;Histone-Lysine N-Methyltransferase;Histones;Human;human pathogen;Immune;Immune Evasion;Immune Response Genes;improved;Individual;Infection;inhibitor;insight;Legionella pneumophila;Legionnaires' Disease;Lysine;metaplastic cell transformation;Methylation;Methyltransferase;microbial;Modeling;Modification;Mutate;non-Native;Norleucine;Nucleosomes;pathogen;pathogenic bacteria;Pathogenicity;Pattern;Peptides;Physiology;preference;Preparation;Process;programs;Proliferating;Proteins;Regulation;Sampling;screening;SET Domain;Signal Pathway;Structure;Testing;Transcriptional Regulation;Work

PROJECT_TITLE: Mechanisms of histone crosstalk with bacterial pathogens

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Extrachromosomal DNA (ecDNA) is a type of genetic element that cancer cells use to amplify oncogenes and is expressed in a variety of cancer types. The goal of this project is to understand how ecDNA provides cancer cells with new ways to accelerate cancer growth and to explore a potential therapy for mitigating their effects. Thus, this project will increase our understanding of the role of these elements in cancer and could yield a generalizable complementary approach for cancer treatment.

PI_NAMEs: VERHAAK, ROEL GW (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Acceleration;Affect;Amplifiers;Animal Model;autosome;Behavior;Binding;Biological Models;Biology;cancer cell;Cancer Cell Growth;cancer therapy;cancer type;cell behavior;cell killing;Cell model;Cells;Characteristics;Chromatin;Chromatin Interaction Analysis by Paired-End Tag Sequencing;Chromosomal Duplication;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Cytopathology;Cytoplasm;Data;Data Set;Deoxyribonucleotides;Development;DNA;DNA amplification;DNA biosynthesis;DNA Sequence Alteration;dosage;Double Minutes;Elements;endonuclease;Enhancers;Enzymes;Esophageal carcinoma;Evolution;extrachromosomal DNA;Frequencies;gemcitabine;Gene Amplification;genetic element;Genetic Transcription;Genome;genomic locus;Genomics;Glioblastoma;Goals;Growth;Heterogeneity;hydroxyurea;In Vitro;in vivo Model;innovation;insight;interest;Knowledge;Label;Laboratories;Location;Maintenance;Malignant Neoplasms;Mediating;Methods;Methotrexate;micronucleus;Mitosis;Modeling;Molecular;Monitor;neoplastic cell;Neurosphere;novel;Oncogene Activation;Oncogenes;Oncogenic;Outcome;patient derived xenograft model;Patients;pharmacologic;Proteins;real-time images;Regulation;Reporting;Research;Resistance;Ribonucleotide Reductase;Ribonucleotide Reductase Subunit;RNA Polymerase II;Role;RRM1 gene;RRM2 gene;S phase;Sarcoma;Solid;Structure;System;Technology;Testing;Therapeutic;therapeutic target;Time;tool;tripolyphosphate;tumor;tumor DNA;tumor growth;tumor heterogeneity;tumorigenesis;virtual;Visualization;Visualization software;Work

PROJECT_TITLE: Extrachromosomal DNA as a Targetable Mechanism in Glioblastoma

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative The proposed project is relevant to the public because sarcoidosis is a common interstitial lung disease that often causes disability, and for which effective and affordable treatments are not currently available. The successful completion of this project will provide novel insights into the pathogenesis of sarcoidosis, which could guide the development of more effective treatments by repurposing existing therapeutic agents. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to developing fundamental knowledge that will reduce the burdens of illness and disability.

PI_NAMEs: CROUSER, ELLIOTT D (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Address;Affect;Aldosterone;Angiotensin II;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Angiotensinogen;Angiotensins;aspirate;Attenuated;Biological Markers;burden of illness;Cardiovascular Diseases;Characteristics;Circulation;Clinical;Clinical Trials;Crohn's disease;Data;Development;disability;Disease;disease model;Disease Progression;Drug Modulation;effective therapy;Enzyme Inhibition;Equilibrium;experience;Fibrosis;Funding Mechanisms;Goals;Granuloma;Granulomatous;Granulomatous disease;Hormones;Human;human tissue;Immune response;In Vitro;in vitro Model;Inflammation;Inflammatory;inhibitor;innovation;insight;Interleukin-10;Interstitial Lung Diseases;Investigation;Knowledge;Link;Lung;Macrophage;Mediating;Mineralocorticoid Receptor;Mission;Modeling;Molecular;Molecular Target;Morphology;new therapeutic target;novel;novel marker;novel therapeutics;Pathogenesis;Pathologic;Pathway interactions;Patients;Peptidyl-Dipeptidase A;Phagosomes;Pharmaceutical Preparations;Phenotype;Pilot Projects;Play;potential biomarker;predictive marker;predictive modeling;prognostication;Pulmonary Sarcoidosis;receptor;Receptor Activation;Renin-Angiotensin-Aldosterone System;Research;Research Design;response;Role;Sarcoidosis;Signal Pathway;Signal Transduction;STAT3 gene;Therapeutic Agents;therapeutic target;Time;Tissues;United States National Institutes of Health;virtual

PROJECT_TITLE: Role of Renin-Angiotensin-Aldosterone System during sarcoidosis granuloma formation

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Salt-sensitive hypertension is a costly public health problem that is more prevalent in Black adults, but the mechanisms underlying salt-sensitivity are poorly understood in humans. Rodent data suggests sodium is sensed in the circumventricular organs of the brain, which control neurohumoral regulation of blood pressure, partly via Na+-K+-2Cl- co-transporter. The purpose this study is to determine the role of the Na+-K+-2Cl- co- transporter in central sodium sensing and neurohumoral regulation of blood pressure in a population that is more prone to salt-sensitive hypertension, Black adults.

PI_NAMEs: STOCK, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acute;Adult;antagonist;Area;Argipressin;Attenuated;attenuation;Black race;Blood;Blood - brain barrier anatomy;blood oxygen level dependent;Blood Pressure;blood pressure regulation;Blood Volume;Brain;Brain region;Cardiovascular Diseases;Central Nervous System;combat;Consumption;cost;Data;dietary excess;Dietary Sodium;Functional Magnetic Resonance Imaging;Furosemide;Goals;Homeostasis;Human;Hypernatremia;Hypertension;Infusion procedures;innovation;Kidney;Mediating;Nerve;Neurons;neurovascular;novel;novel therapeutic intervention;Organ;Play;Population;Positioning Attribute;pressure;Public Health;Publishing;receptor;Regulation;response;Rodent;Role;Saline;salt sensitive;salt sensitive hypertension;Serum;Signal Transduction;Sodium;Sodium Chloride;Stimulus;symporter;Testing;Translating;translational approach;United States;Water

PROJECT_TITLE: Mechanisms of Central Sodium Sensing and Salt-Sensitive Hypertension


NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Nanotechnology

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: Narrative Public Health Relevance Statement: Candida is a leading cause of disseminated candidiasis. Candida proteome contains evolutionarily acquired amino acid insertion sequences, only present in CTG-clade fungi. We will study the role of these inserts in other C. albicans proteins, and use them as focal targets for drug development.

PI_NAMEs: UPPULURI, PRIYA  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Affinity;Affinity Chromatography;Amino Acid Sequence;Amino Acids;anti-fungal agents;Antifungal Therapy;aqueous;Biodistribution;Biological;biological adaptation to stress;Biological Assay;Biological Availability;Candida;Candida albicans;Candida auris;Candidiasis;Carbon;Cell Wall;Cells;Clinical;Co-Immunoprecipitations;Codon Nucleotides;Databases;Death Rate;Development;Disseminated candidiasis;DNA Insertion Elements;Docking;Dose;Drug Controls;drug development;Drug Kinetics;Drug Targeting;Encapsulated;Epitopes;Eudragit;Eukaryota;fascinate;FDA approved;Filament;Formulation;forward genetics;Frequencies;fungus;gain of function;Gel;Gene Family;Gene Proteins;Generic Drugs;Genes;Genetic Screening;genome-wide;Growth;Human;Hydrophobicity;Immune Evasion;improved;in silico;In Vitro;in vivo;in vivo evaluation;Individual;inhibitor;Invaded;Leucine;Ligands;link protein;Mass Spectrum Analysis;Medical Device;member;Membrane;Microbial Biofilms;Mitochondria;Modeling;mouse model;Mucous Membrane;Multi-Drug Resistance;Mus;Mutagenesis;mutant;Mycoses;nanoparticle;NMR Spectroscopy;novel;Open Reading Frames;Oral;Oral Administration;Oral candidiasis;Oral mucous membrane structure;Organism;oropharyngeal thrush;pathogen;Pathogenicity;Penetration;Phagocytosis;Pharmaceutical Preparations;pharmacologic;Phosphorylation Site;Phylogenetic Analysis;Polymers;prevent;Property;Protein Biochemistry;protein protein interaction;Proteins;Proteome;public health relevance;Reporting;Respiration;Role;screening;Sepsis;Serine;Solubility;Source;Spectroscopy, Fourier Transform Infrared;Stress;Stretching;Structure;success;Surface;surfactant;Testing;Time;Toxic effect;trait;Translating;Treatment Protocols;vaginal candidiasis;Virulence;Water;Yeasts

PROJECT_TITLE: Targeting evolutionarily acquired insertion sequences in Candida species, for development of antifungal drugs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(02)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Prevention;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE Domestic oil and gas production in the United States has surged over the last decade has the potential release multiple air pollutants, which can be harmful to the health of nearby residents. Our proposed community-driven project will establish a cohort of multiethnic residents in South Los Angeles near diverse urban oil drilling sites to objectively assess the impact of drilling operations on neighborhood air quality and respiratory health and translate that knowledge into public health action.

PI_NAMEs: JOHNSTON, JILL E (contact);SHAMASUNDER, BHAVNA

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Academia;Address;Air;air monitoring;Air Pollutants;Air Pollution;Area;Asian;Asthma;Birth;Black race;California;Caucasians;Cities;cohort;Collaborations;college;Color;Communities;community academic partnership;Community Actions;community collaboration;community engagement;community engagement process;Community Health Education;community living;community organizations;community partners;community partnership;community research;cost;Country;County;Coupled;Data;Data Collection;density;design;Development;Educational Materials;Emergency Situation;Environment;environmental health disparity;environmental justice;epidemiology study;Event;Exposure to;Face;Family;Fossil Fuels;Gases;Goals;Government;Health;health assessment;health data;health plan;Health protection;Health Status;Hematologic Neoplasms;Home;Hydrocarbons;immune function;Impairment;innovation;Interview;Knowledge;Latinx;Link;Los Angeles;Low income;Measures;Monitor;multi-ethnic;Natural Gas;Neighborhoods;Oils;operation;Outcome;Participant;Personal Satisfaction;Petroleum;Phase;pollutant;Pollution;Population Growth;Pregnancy;prevent;Production;Prospective Studies;Public Health;pulmonary function;Recommendation;recruit;Reporting;Research;Research Project Grants;Respiratory Disease;respiratory health;response;Risk;Rural Community;Schools;secondary analysis;sensor;Site;Source;Structure;Symptoms;temporal measurement;Time;Translating;United States;Universities;Urbanization;Visit;Voice;Vulnerable Populations;Wheezing;Work

PROJECT_TITLE: Los AngeleS Voices on Oil, Community, Environment and Salud (LAS VOCES) Study