NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research;Patient Safety;Rehabilitation;Telehealth

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE To improve quality of life among individuals with chronic [low back] pain, there is a critical need to develop mobile health (mHealth) tools that promote safe, effective, and accessible self-management of pain. This research is innovative because it tests a novel mHealth tool— mobile neurofeedback— that uniquely enables self-management of chronic [low back] pain to be performed easily and safely anytime, anyplace. If this study yields positive results, it has potential to fundamentally change patients’ ability to manage pain on their own.

PI_NAMEs: ELBOGEN, ERIC B. (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: 18 year old;Adult;Alprostadil;American;auditory feedback;Autonomic nervous system;Back;barrier to care;Biofeedback;Biometry;Bluetooth;Brain;Chronic;Chronic low back pain;chronic pain;chronic pain management;chronic pain patient;Clinic;Clinic Visits;Clinical Trials;Collaborations;comparison group;cost;Data;Development;Devices;Double-Blind Method;effective therapy;effectiveness testing;Electroencephalography;emotional distress;Environment;Family;foot;functional improvement;Goals;handheld mobile device;Health;Home;improved;Individual;innovation;Intervention;Link;Low Back Pain;Measures;Mediating;Medical;meetings;mHealth;mHealth self-management;mobile application;Mobile Health Application;Names;neurofeedback;Nonpharmacologic Therapy;novel;Occupational;opioid abuse;Outcome;Pain;Pain Clinics;Pain intensity;Pain interference;Pain management;pain outcome;pain reduction;Pain Research;pain self-management;Participant;Patient Education;patient registry;Patients;Persons;pharmacologic;Pharmacological Treatment;Physical Function;Physiological;Placebo Control;Placebo Control Effect;Placebos;portability;Quality of life;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Relaxation;Reporting;Research;Research Personnel;Risk;Role;safe patient;Self Efficacy;Self Management;Serious Adverse Event;Signal Transduction;social;Speed;symptom self management;Technology;Testing;Time;tool;Touch sensation;Training;Translating;Travel;United States National Institutes of Health;Universities;validation studies;Visual;Vocation;Walking

PROJECT_TITLE: Promoting Effective Self-Management of Chronic Pain with mHealth Neurofeedback

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: GALVESTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) is the most common cause of dementia, manifesting as progressive memory loss and other cognitive functions. An objective blood-based biomarker that can predict and identify AD is a currently needed treatment modality. Herein, we will use a combination of a modified small RNA-seq and a newly developed quantification method to investigate whether the changes in tRF expression can differentiate AD from other neurodegenerative conditions and identify its preclinical stage.

PI_NAMEs: BAO, XIAOYONG  (contact);FANG, XIANG

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Affect;aged;Alzheimer disease prevention;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;Amyloid;Amyotrophic Lateral Sclerosis;angiogenin;Anticodon;Bioinformatics;Biological;Biological Assay;Biological Markers;biomarker panel;Biometry;Blood;blood-based biomarker;Brain;brain magnetic resonance imaging;Cerebrospinal Fluid;Clinical;Clinical Services;Cognitive;cognitive function;cognitive testing;Data;Dementia;Development;diagnostic biomarker;diagnostic tool;differential expression;Disease;disease diagnosis;disease diagnostic;Disease Progression;disorder prevention;endonuclease;epidemiology study;Evaluation;experience;Family;feature selection;fluorodeoxyglucose positron emission tomography;follow-up;Future;Genes;Goals;Hippocampus;Human;improved;Individual;insight;Lead;Longitudinal Studies;Machine Learning;Memory Disorders;Memory Loss;Methods;MicroRNAs;mild cognitive impairment;Modality;molecular marker;Monitor;National Institute on Aging;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;Neuropsychology;nonalzheimer dementia;novel;novel diagnostics;Parents;Parkinson Disease;Patients;Peripheral;Persons;Phase;Plasma;Positron-Emission Tomography;pre-clinical;Prevention;Process;Prognosis;prognostic;Prognostic Marker;Publications;Qualifying;Quantitative Reverse Transcriptase PCR;Reporting;Research;research clinical testing;Ribonucleases;RNA;Role;Sampling;Scanning;Screening procedure;Serum;Severity of illness;skills;Small RNA;tau Proteins;tau-1;Testing;Tissues;transcriptome sequencing;Transfer RNA;Translational Research;Treatment Efficacy;Untranslated RNA;Visit

PROJECT_TITLE: tRNA-derived RNA Fragments (tRF) as Prognostic and Diagnostic Biomarkers for Alzheimer’s Disease

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative Heart failure affects over six million Americans, leading to a wide range of life-threatening conditions that are not adequately treated with existing drugs. Here, we combine computational modeling, experiments on heart cells, and experiments with mice to identify FDA-approved drugs that may mitigate the abnormal growth of the heart that precedes heart failure.

PI_NAMEs: SAUCERMAN, JEFFREY J. (contact);WOLF, MATTHEW J

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Address;Adrenergic Agents;Affect;American;Angiotensin II;Angiotensins;Animal Model;Antibodies;Aorta;Arteries;Biochemical;Biological Assay;Cardiac Myocytes;Cardiac Output;Cells;Clinical;Computer Models;constriction;Data;Databases;Death Rate;design;Devices;drug candidate;Drug Combinations;drug mechanism;Drug Modulation;drug repurposing;Drug Screening;Drug Targeting;Drug usage;Echocardiography;Educational workshop;Event;falls;FDA approved;Goals;Growth;Health;Heart;Heart failure;Heart Hypertrophy;Human;Hypertrophy;improved;In Vitro;in vivo;Individual;individualized medicine;Infusion procedures;innovation;insight;Investigation;Investments;Knowledge;Measures;mechanical signal;Medical Care Costs;Methods;Microscopy;Modeling;Molecular;Molecular Biology;Morbidity - disease rate;mortality;mouse model;muscle form;Myocardium;National Heart, Lung, and Blood Institute;Neonatal;network models;Neuregulin 1;novel therapeutics;Office Visits;Organ;Pathway interactions;Patient-Focused Outcomes;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenylephrine;predictive modeling;Preparation;pressure;Prevalence;Rattus;Recommendation;Regulation;Renin;response;Signal Pathway;Signal Transduction;Signaling Molecule;simulation;Strategic vision;System;targeted treatment;Testing;therapeutic target;Translating;United States National Institutes of Health;Validation;Work;Writing

PROJECT_TITLE: Systems Pharmacology Model of Cardiac Hypertrophy

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE (Public Health Relevance) Significant expense and effort by groups of scientists around the world has led to identification of regions of the human genome that are associated with the genetic risk for various forms of cardiovascular disease, including coronary artery disease. Additional research is required to understand the specific genes involved, and how they work to contribute to the disease process. Such information will allow for better risk assessment and the development of better therapeutics for these diseases.

PI_NAMEs: QUERTERMOUS, THOMAS  (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: AHR gene;Alleles;Anatomy;Animals;Apolipoprotein E;Aryl Hydrocarbon Receptor;Atherosclerosis;Autocrine Communication;Binding;Blood Vessels;Cardiovascular Diseases;cell dedifferentiation;Cell Lineage;Cell model;cell type;Cells;Chromatin;Chromosome Mapping;Complement Factor D;Coronary Arteriosclerosis;Coronary artery;Coupled;CRISPR interference;Data;Development;Disease;disorder risk;Enhancers;Epigenetic Process;Fibroblasts;Functional disorder;Gene Expression;gene function;Gene Targeting;Genes;Genetic Risk;Genetic Transcription;genome wide association study;genome-wide;Goals;Growth Factor;Human;Human Genome;In Vitro;in vivo;Knock-out;Knockout Mice;LacZ Genes;Link;MADH3 gene;Maps;Measures;Mediating;Modeling;Molecular;Morphology;mouse model;Mus;PDGFA gene;PDGFRB gene;Phenotype;Platelet-Derived Growth Factor;Probability;Process;programs;public health relevance;receptor;Regulation;Reporter;Research;response;Risk Assessment;Role;Scientist;Signal Pathway;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Smooth Muscle Myocytes;Stromal Cell-Derived Factor 1;Subcellular Anatomy;Therapeutic;Tissues;transcription factor;Transcription Process;Transcriptional Activation;transcriptomic profiling;transcriptomics;TWIST1 gene;vascular stress;whole genome;Wild Type Mouse;Work

PROJECT_TITLE: PDGFD regulates a transcriptional network to modulate smooth muscle cell transition and coronary artery disease risk

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative (Public Health Relevance Statement) Biomolecular condensation of RNA and proteins has been implicated in the pathogenesis of various neurodegenerative diseases such as Parkinson's and Alzheimer's, yet the physiological role and mechanism by which an mRNA condenses are unknown. The research program proposed aims to understand the molecular mechanisms and physiological function of mRNA condensation in the budding yeast S. cerevisiae during temperature stress.

PI_NAMEs: GLAUNINGER, HENDRIK  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: 5' Untranslated Regions;Affect;Alzheimer's Disease;Behavior;Binding;Biochemical;biological adaptation to stress;Biological Assay;biophysical properties;candidate validation;Cells;Cellular Stress;Cytoplasm;Cytoprotection;Data;Development;Disease;Environment;environmental stressor;Functional disorder;functional outcomes;Future;gene induction;Genes;Genetic Transcription;Heat shock proteins;Heat Stress;Heat-Shock Response;high throughput analysis;Homeostasis;Homologous Gene;Hypoxia;Impairment;In Vitro;in vivo;Individual;Knowledge;Link;Measures;Mediating;Messenger RNA;Molecular;Mutation;Neurodegenerative Disorders;nutrient deprivation;Organism;Parkinson Disease;Pathogenesis;Peptide Initiation Factors;Physical condensation;Physiological;posttranscriptional;prevent;Process;Production;programs;Protein Biosynthesis;Proteins;Proteome;public health relevance;Reaction;recruit;Reporter;Research;response;RNA;RNA-Binding Proteins;Role;Saccharomyces cerevisiae;Saccharomycetales;Sedimentation process;Solubility;Stress;System;Temperature;Testing;Transcript;transcriptome;transcriptome sequencing;Translating;Translation Initiation;Translational Regulation;Translational Repression;Translations;unpublished works;Up-Regulation;virtual;Work;Yeasts

PROJECT_TITLE: Understanding mRNA Condensation and Its Role in Translational Control during Stress

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-U(20)L]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: The production of new neurons throughout life in the dentate gyrus is critical for function of the hippocampus, and after seizures there is increased production of new neurons but the formation of abnormal circuitry. We have identified a role of mossy cells in the hilus in the production of a secreted factor that regulates dentate neurogenesis in an activity dependent manner. In addition, we examine the formation of developmental circuits in the dentate that regulate the development of the dentate stem cells.

PI_NAMEs: PLEASURE, SAMUEL JEREMY (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Address;Adult;adult neurogenesis;Affect;Appearance;Attenuated;Brain region;Cajal-Retzius cells;Cells;Consumption;Cytoplasmic Granules;Data;dentate gyrus;designer receptors exclusively activated by designer drugs;Development;Embryo;entorhinal cortex;environmental change;environmental enrichment for laboratory animals;Epilepsy;excitatory neuron;Exercise;exhaustion;Funding;Grant;Heterozygote;Hippocampus;insight;Knock-out;Learning;Life;Link;Maintenance;Memory;morphogens;Mus;mutant;Neonatal;nerve stem cell;neural;neural circuit;neurogenesis;neuron component;neuronal circuitry;Neurons;newborn neuron;postnatal;Production;Proliferating;Rabies;rabies viral tracing;Role;Seizures;Signal Transduction;Signaling Molecule;stem cells;Stimulus;System

PROJECT_TITLE: Control of dentate neurogenesis: Shh, mossy cells, activity and seizures

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Human Genome;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Sepsis;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: GAINESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Severe infection (sepsis) and severe injury (trauma) provoke pathology in a patient’s white blood cells that influences their poor long-term outcomes after initially surviving their admission to an intensive care unit. This project will allow this investigator to better understand this harmful state and potential treatment options.

PI_NAMEs: EFRON, PHILIP A (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: acute care;Admission activity;Affect;Age;Biology;Blood;Bone Marrow;Catabolism;CD8-Positive T-Lymphocytes;Cell Separation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chronic;Chronic Care;Clinical;cognitive performance;cohort;Critical Illness;cytokine;Development;Epigenetic Process;Foundations;Functional disorder;Genomics;Goals;Hematopoietic stem cells;Hospitalization;Hospitals;Human;Immune response;Immunosuppression;improved;Infection;Inflammation;Inflammatory;Intensive Care Units;Intervention;Laboratories;Leukocytes;Link;Macrophage;Metabolic;MicroRNAs;Morbidity - disease rate;Mus;Myelogenous;Myeloid Cell Activation;Myeloid-derived suppressor cells;Myelopoiesis;Nitric Oxide;Organ;Outcome;oxidation;Pathologic;Pathology;Patient Self-Report;Patient-Focused Outcomes;Patients;peroxidation;Phenotype;Populations at Risk;Prevalence;prevent;Principal Investigator;Production;Productivity;prophylactic;Quality of life;rational design;Research;Research Personnel;Sepsis;septic patients;severe injury;sex;stem cells;Surgical Intensive Care;Survivors;Syndrome;Therapeutic Intervention;Trauma;Trauma patient;Work

PROJECT_TITLE: Pathological Myeloid Activation After Sepsis and Trauma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: LOUISVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative. Taste disorders can have detrimental effects on a person's health and quality of life. The underlying mechanisms of these disorders are not understood but may result from disruption of the connections between taste buds and the neurons carrying taste information to the brain. Here, we are exploring the relationship between taste neuron structure, connectivity, and function to elucidate the role of connectivity in taste disorders.

PI_NAMEs: KRIMM, ROBIN FRANCES (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Adult;Anatomy;Axon;Brain;Brain-Derived Neurotrophic Factor;Calcium;cell type;cellular transduction;Characteristics;Chemicals;Citric Acid;Communication;Development;Disease;Epithelium;experimental study;Food;Functional Imaging;functional plasticity;Ganglia;Gene Expression;Genetic;Goals;Health;Hour;Image;in vivo;Individual;insight;intravital imaging;Intrinsic factor;Label;life span;Link;Measurement;Measures;Methods;Morphology;Mus;Nerve Fibers;Neurons;neurotrophic factor;overexpression;Pattern;Peripheral;Persons;Population;preproenkephalin;Process;proenkephalin;Quality of life;Receptor Cell;reconstruction;Regulation;Role;sensory system;Stimulus;Structure;Taste Bud Cell;Taste Buds;Taste Disorders;Taste Perception;taste stimuli;taste system;taste transduction;Temperature;Time;two photon microscopy;Variant;Wild Type Mouse

PROJECT_TITLE: Regulation of taste neuron morphology and function

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE More than one-third of all enzymes are metalloenzymes (metal-dependent enzymes). Developing inhibitors against metalloenzymes is valuable for the treatment of many illnesses, especially viral infections such as the flu. This program will develop innovative approaches to the discovery of more effective metalloenzyme inhibitors by providing new concepts, methods, and chemical matter for drug development against this important target class.

PI_NAMEs: COHEN, SETH M (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: Acidity;Active Sites;Address;Affinity;Affinity Chromatography;Bacterial Infections;Binding;Biochemical;Biological Assay;Biological Process;Biotechnology;Carboxylic Acids;Case Study;Cells;cellular targeting;Characteristics;Chemicals;Clinical;clinically relevant;Collaborations;Cytoprotection;Data;design;Development;Disclosure;Disease;drug development;drug discovery;endonuclease;Enzymes;Equipment and supply inventories;experimental study;flu;flu activity;functional group;Funding;Health;HIV/AIDS;Human;human disease;Hypertension;improved;In Vitro;in vitro activity;Influenza;influenzavirus;inhibitor;innovation;insight;Ions;Laboratories;Legal patent;Length;Libraries;lipophilicity;Malignant Neoplasms;Mammalian Cell;Measures;Mentors;Metal Ion Binding;metalloenzyme;Metals;meter;Methods;Modeling;Multi-Drug Resistance;N-terminal;Nature;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacophore;Play;Polymerase;Prevalence;programs;Proliferating;Property;Proteins;Publications;Research;Role;scaffold;skills;small molecule;small molecule inhibitor;small molecule therapeutics;symposium;Therapeutic;Therapeutic Uses;Translations;uptake;Viral;Viral Physiology;Virus;Virus Diseases

PROJECT_TITLE: Metal-binding Isosteres for Influenza Endonuclease Inhibitors and Beyond

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Program Director/Principal Investigator (Last, First, Middle): Bowdish, Michael Eugene PROJECT NARRATIVE We propose to establish the University of Southern California Cardiovascular and Thoracic Surgery Stimulating Access to Research in Residency (USC-CVTS StARR) Program to foster the development of clinician- investigators in the field of cardiovascular and thoracic diseases, by enhancing the recruitment and retention of talented residents into successful research careers, while also meeting requirements for medical board eligibility. Three highly competitive training programs in the Department of Surgery, the General Surgery Residency Program, the Integrated Vascular Surgery Residency Program, and the Integrated Cardiothoracic Surgery Residency Program, are uniquely positioned to participate in the R38 program. Through the development of an Independent Career Development Plan (ICDP), composed of research, education, and mentorship components, we will establish a program that will lead to both clinical and research competency and establish a lifelong methodological foundation overlaid with additional competencies in communications, grant-writing, leadership and team science that are requisite for success as independent career investigators. OMB No. 0925-0001/0002 (Rev. 03/16 Approved Through 10/31/2018) Page Continuation Format Page

PI_NAMEs: ALLEN, KEITH B.;STARNES, VAUGHN A (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Acceleration;Address;Area;Blood Vessels;burden of illness;California;Cardiovascular Diseases;Cardiovascular Surgical Procedures;Cardiovascular system;career;career development;Cities;Clinical;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communication;community engagement;Competence;Conduct Clinical Trials;cost estimate;Decision Making;design;Development;Development Plans;Economics;Education;Eligibility Determination;ethnic diversity;experience;Fellowship;Fostering;Foundations;frontier;Funding;Future;Gender;Geographic Locations;Grant;health economics;Health Policy;Healthcare;Heart;Hispanic Populations;implementation research;implementation science;improved;Industry;innovation;Institution;Kansas;Knowledge;Leadership;Link;low socioeconomic status;Mechanics;Medical;meetings;Mentors;Mentorship;Methodology;Methods;mortality;multidisciplinary;National Heart, Lung, and Blood Institute;Network Infrastructure;next generation;novel;novel strategies;Operative Surgical Procedures;Outcomes Research;participant enrollment;Patient-Focused Outcomes;Patients;Performance;Population;Positioning Attribute;Principal Investigator;programs;Race;racial diversity;Randomized, Controlled Trials;recruit;Research;Research Methodology;Research Personnel;Residencies;Resources;Rural Population;Saints;San Francisco;Science;Seminal;Site;skills;success;Talents;Thoracic Diseases;Thoracic Surgical Procedures;Training;Training Programs;Translating;Translational Research;Translations;trial design;United States;United States National Institutes of Health;Universities;Washington;Writing

PROJECT_TITLE: CTSN


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE We propose to deliver PCATS.JIA, a patient-centered shared decision-making tool for use at point of care to improve quality and outcomes of clinical care for children with JIA. The tool will be co-designed with its end- users (patients, clinicians), along with experts in user-centered design, data scientists, and health services and outcomes researchers. We will design and test implementation within the setting of a 23-center Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN), leveraging our existing validated computational tool based on an advanced Bayesian nonparametric causal learning algorithm.

PI_NAMEs: HUANG, BIN ;MORGAN, ESI M (contact)

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: Inform Shared Decision-making with Advanced Bayesian Causal Inference to Improve Quality of Pediatric Rheumatology Care

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ADMINISTERING_IC: MH

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Estrogen;Mental Health;Neurosciences;Women's Health Research

ORG_CITY: PISCATAWAY

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Chronic exposure to stressful experiences can result in maladaptive affective states yielding behavioral disturbances in rodents and stress-related mood disorders in humans. One potential cause is corticotropin- releasing hormone (CRH) signaling in bed nucleus of the stria terminalis (BNST), which is a sexually dimorphic integrative center for limbic information and valence monitoring. CRH-expressing BNST neurons (in the oval subnucleus) are critical mediators of the chronic stress response and may underlie sex differences therein. Our proposed studies will examine the role of BNST CRH signaling as a nexus for chronic stress-induced behavioral outcomes increasing our understanding of the impact of chronic stressors on affective states in both sexes.

PI_NAMEs: ROEPKE, TROY ADAM (contact);SAMUELS, BENJAMIN A

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Address;Affect;Affective;Amygdaloid structure;Anxiety;Area;Aromatase;Arousal;Behavior;Behavior Disorders;Behavioral;behavioral outcome;biological adaptation to stress;Brain region;Cell Nucleus;cell type;Cells;Chronic;Chronic Disease;Chronic stress;Cognition;Collaborations;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;Coupled;CRF receptor type 1;Data;Electrophysiology (science);Estrogen Receptors;Estrogens;Exposure to;Female;Genetic;Genomics;Hippocampus;hormonal signals;Human;Hypothalamic structure;Immunohistochemistry;Knockout Mice;locus ceruleus structure;male;Mediating;Mediator;Membrane Potentials;Molecular;Monitor;Mood Disorders;mouse model;Mus;Negative Valence;neural circuit;neuronal excitability;Neurons;neurophysiology;novel;optogenetics;Output;Pathway interactions;physiologic stressor;Population;Positive Valence;Predisposition;prevent;Property;psychological stressor;receptor binding;Receptor Signaling;Rest;Rodent;Role;sex;Sex Differences;sexual dimorphism;Signal Transduction;social;social defeat;social stressor;Steroids;Stress;stress disorder;stress resilience;Stressful Event;stressor;Structure;Structure of terminal stria nuclei of preoptic region;Techniques;transcriptome;Transgenic Mice;Transgenic Organisms;Translating;Variant;Viral

PROJECT_TITLE: Sex differences in CRH signaling in the ovBNST underlie effects of chronic stressors

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PHR: PROJECT NARRATIVE The development of a safe and effective prophylactic HIV vaccine has been a long sought, but unfulfilled goal of biomedical research, essential for the ultimate control of the HIV epidemic. We propose a novel approach to develop HIV prophylactic vaccines, using a new vaccine platform that we developed, Killed Whole Cell Genome-Reduced Bacterial vaccines that express vaccine antigens on the surfaces of the bacteria, targeting two highly conserved viral antigens, the HIV Membrane Proximal External region and the Fusion Peptide region of the viral envelope protein. Recombinant bacterial vaccines can produce good antibody and cell- mediated immune responses, are very inexpensive to produce, do not require ultra-cold storage conditions, and be administered via a non-parenteral route, without need of highly trained medical professionals, and are thus highly suitable for global use.

PI_NAMEs: ZEICHNER, STEVEN L. (contact)

PROGRAM_OFFICER_NAME: SHAPIRO, STUART Z

PROJECT_TERMS: 2019-nCoV;Adjuvant;Animal Model;Antibodies;Antibody Binding Sites;Antibody Formation;antigen-specific T cells;Antigens;Bacteria;Bacterial Vaccines;Binding;Binding Sites;Biological Assay;Biomedical Engineering;Biomedical Research;cell mediated immune response;Cells;Cellular Immunity;Chimeric Proteins;Clinical;clinical efficacy;Cold Chains;Combined Vaccines;Consensus;Coronavirus;cost;Cryopreservation;Data;design;Development;Disease;DNA;DNA biosynthesis;Dose;early phase clinical trial;Engineering;Enzyme-Linked Immunosorbent Assay;Epidemic;Escherichia coli;Escherichia coli Vaccines;Exhibits;Family suidae;forgiveness;Funding;Future;Genome;Goals;Hand;high reward;high risk;HIV;HIV Antigens;HIV vaccine;HIV-1;HIV-1 vaccine;Human;Immune response;Immunize;immunogenicity;improved;in vivo evaluation;Inactivated Vaccines;Industrialization;innovation;International;Knowledge;Letters;Manufacturer;manufacturing capabilities;Medical;meetings;Membrane;Modeling;Monitor;Monoclonal Antibodies;monomer;mouse model;Mus;neutralizing antibody;neutralizing monoclonal antibodies;nonhuman primate;novel;novel strategies;novel vaccines;Peptide Vaccines;Peptides;Phase;Plasmids;porcine epidemic diarrhea virus;Positioning Attribute;Preventive vaccine;Production;prophylactic;Proteins;Recombinants;Recording of previous events;Research;response;Route;Safety;safety assessment;skills;Structure;Study models;success;Surface;synthetic biology;System;T cell response;Technology Transfer;Testing;Training;Translating;Vaccinated;Vaccination;Vaccine Antigen;vaccine candidate;vaccine development;vaccine immunogenicity;vaccine platform;Vaccine Production;vaccine response;Vaccines;Viral Antigens;Viral Envelope Proteins;Viral Fusion Proteins;Virus;Virus Diseases;Whole Cell Vaccine;Work

PROJECT_TITLE: Globally Appropriate Genome Reduced Killed Whole Bacterial HIV Vaccines

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative  Angiogenesis in the developing retina requires communication between endothelial cells, pericytes and myeloid cells, and dysregulated communication between the three cell types drives ocular neovascular diseases (ONDs) that are currently treated with anti-VEGF agents that target endothelial cells only. In this proposal, we identify the secreted Slit2 ligand as an activator of retinal neovascularization that acts through Robo receptor signaling in pericytes and myeloid cells, and show that Slit-Robo pathway inhibition reduces OND in mouse models. By identifying mechanisms of Robo-mediated signaling in pericytes and myeloid cells we will uncover novel biology controlling retinal development and homeostasis that could be applied to OND prevention and may confer additional benefit over VEGF inhibition of endothelial cells alone.

PI_NAMEs: EICHMANN, ANNE CHRISTINE (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Affect;Age related macular degeneration;American;angiogenesis;Angiogenesis Inhibitors;Biological;Biology;Blindness;Blood Vessels;Blood-Retinal Barrier;cell motility;cell type;Cells;Communication;cytokine;Data;Development;Diabetic Retinopathy;Disease;Disease Progression;disorder prevention;Elderly;Endothelial Cells;Endothelial Growth Factors;Endothelium;Gene Expression;Growth Factor Inhibition;Hemorrhage;Homeostasis;Human;Impairment;Inflammation;Inflammatory;interest;Invaded;Knowledge;Ligands;Mediating;Membrane;migration;Molecular;mouse model;Mus;Myelogenous;Myeloid Cells;neovascular;neovascularization;neurovascular coupling;novel;novel strategies;novel therapeutics;ocular neovascularization;Pathologic Neovascularization;Pathology;Pathway interactions;Patients;Pericytes;polypeptide;prevent;Proliferating;receptor;Receptor Signaling;response;Retina;retinal angiogenesis;Retinal Neovascularization;Retinopathy of Prematurity;Role;Signal Transduction;single-cell RNA sequencing;targeted agent;Therapeutic;Therapeutic Agents;Treatment Factor;Vascular Diseases;Vascular Endothelial Growth Factors;Vision;Visual

PROJECT_TITLE: Slit2-ROBO signaling in pericytes and myeloid cells controls vascular development and ocular neovascular disease

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Behaving adaptively in our environment requires noticing the patterns around us and storing the learned information for long-term use. This project examines how the brain can quickly and effectively encode these patterns and how it then processes and solidifies this new information across time and sleep. A detailed understanding of these mechanisms could suggest new targets for intervention in mental health disorders such as depression and schizophrenia with profound disturbances to learning and sleep.

PI_NAMEs: SCHAPIRO, ANNA C (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: adjudication;Anatomy;Area;Behavior;Brain;Cities;Cognitive;Cues;Data;deep learning model;dentate gyrus;Diagnostic;Diagnostic tests;Distant;Electroencephalography;entorhinal cortex;Environment;Evaluation;experience;experimental study;Functional Magnetic Resonance Imaging;Future;Hippocampus;Individual;Intervention;Knowledge;Knowledge acquisition;Laboratories;Learning;Memory;Mental Depression;Mental disorders;model development;Modeling;Nature;Neocortex;neural;Neural Network Simulation;Neurons;next generation;novel;Participant;Pathway interactions;Pattern;Play;Population;predictive modeling;Predisposition;Process;Research;Resolution;Scanning;Schizophrenia;Shapes;Sleep;Sleep disturbances;sound;Structure;success;Synapses;Testing;theories;Time;Visit;Work

PROJECT_TITLE: Learning novel structure across time and sleep

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: NARRATIVE Changes in the abundance of circulating blood glycoproteins are important experimental and clinical determinants of health and disease; however, the mechanisms regulating blood protein half-lives have been difficult to perceive. We have developed the means to identify the endogenous ligand repertoires of endocytic lectin receptors that control blood glycoprotein half-lives and by using meta-analyses of the data we can predict previously undetected phenotypes and disease signs linked to their dysfunction including inflammation, coagulopathy, cardiovascular defects, and high blood pressure, as well as other physiological effects. This research proposal will investigate lectin receptor ligand repertoires and functions in blood protein homeostasis and its potential collaboration with environmental factors in further determining susceptibility to disease.

PI_NAMEs: MARTH, JAMEY  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Address;Aging;Alleles;Alpha-mannosidase;Animals;anomer;autism spectrum disorder;Autoimmune Diseases;Behavioral;Binding;Bioinformatics;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Coagulation Disorders;blood pressure elevation;Blood Proteins;Blood specimen;Blood Vessels;Brain;Cardiovascular system;Cell surface;cell type;Cells;Chromatography;Chronic;Chronic Disease;Clinical;cohort;Collaborations;Data;Data Analyses;Defect;Degenerative Disorder;Development;Disease;Disease Marker;Distal;Environmental Risk Factor;Eukaryota;Exoglycosidases;Experimental Designs;Fucose;Functional disorder;Galactose;Glycoproteins;Glycoside Hydrolases;Golgi Apparatus;Health;health determinants;Hematology;Human;Hydrolysis;Hypertension;Individual;Inflammation;Inflammatory;inflammatory marker;inhibitor;Innate Immune System;Investigation;Laboratories;Laboratory mice;Lectin;Lectin Receptors;Ligands;Link;link protein;Mammals;Mannose;Mannose Binding Lectin;mannose receptor;Mannosidase;Mass Spectrum Analysis;Measures;Meta-Analysis;Molecular;Monitor;Mus;neural;Neurologic;Onset of illness;Organ;Outcome;pathogen;Pathologic;Pathology;Peptidyl-Dipeptidase A;Peroxidases;Phenotype;Physiological;Physiology;Plasma;Play;Polymers;Polysaccharides;Population;Predisposition;Process;Proteins;Proteome;proteostasis;Protocols documentation;receptor binding;Regulation;Renin;Research Proposals;Role;Sampling;Source;Sterility;Structure;Surface;Syndrome;System;Tissues;Vascular Diseases;vascular inflammation

PROJECT_TITLE: Regulation of Blood Glycoproteins by Lectin Receptors in Health and Disease

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Precision Medicine;Prevention

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE This project seeks to develop personalized models of aggression using data from ecological momentary surveys and passive sensors from smartphones and wearable devices. This approach to studying aggression is important because psychological models of aggression emphasize that it is dynamic and contextualized but aggression is rarely examined in daily life where these dynamics can be studied, hindering our ability to predict and intervene on aggressive urges and behavior in the contexts where they normally occur and are most consequential. By revealing the personalized antecedents of aggressive urges and behavior, we can identify person-specific mechanisms that precede instances of aggression, which in turn will provide crucial information needed to develop personalized, technology-based interventions that can be delivered before the harmful aggressive behavior occurs.

PI_NAMEs: VIZE, COLIN  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: adaptive intervention;Address;Adult;Affect;Age;aggression prevention;Aggressive behavior;analytical method;Anger;Behavior;Behavior Control;Behavior Disorders;behavioral phenotyping;Biological;career;Cellular Phone;Complex;Computing Methodologies;Data;Data Reporting;data streams;Detection;Development;Diagnosis;Diagnostic;economic impact;effective therapy;emotion regulation;Etiology;Family;forest;Future;Goals;gradient boosting;Heart Rate;Heterogeneity;high risk population;improved;inclusion criteria;Individual;innovation;Intervention;Life;Machine Learning;machine learning method;Measurement;Mental disorders;Mentors;Mentorship;Methodology;Methods;mobile sensing;Modeling;Motivation;National Institute of Mental Health;Nature;novel;Participant;Patient Self-Report;Pattern;Personality Traits;personalized intervention;personalized medicine;personalized predictions;Persons;Phenotype;Physiological;Positioning Attribute;predictive modeling;predictive tools;Prevention;Process;programs;prospective;Protocols documentation;psychologic;Psychological Models;Psychopathology;Public Health;random forest;real time monitoring;recruit;Research;Research Design;Research Ethics;research study;Resources;Risk;Risk Factors;Sampling;Scientific Inquiry;Scientist;Selection Criteria;sensor;skills;smartphone based device;Social Environment;Surveys;System;technology intervention;Testing;theories;Time;Training;Universities;wearable device;young adult;Youth

PROJECT_TITLE: Developing Personalized Predictive Models of Aggression

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Urban adolescents and young adults (AYA) face formidable barriers to making healthy decisions core to sexually transmitted infection (STI) prevention, such as, communicating with sex partners and health providers about STI testing, including for the human immunodeficiency virus (HIV), connecting to scientifically accurate STI/HIV informational resources that are culturally and linguistically appropriate, and utilizing the clinical services available to prevent new infections. Using a design thinking framework, we will a) Characterize AYA's use of electronic health record (EHR) patient portals and determine the correlates and patterns of longitudinal use; b) Develop a patient-centered clinical decision support intervention that leverages the EHR patient portal system to optimize patient engagement in STI/HIV prevention behaviors among urban AYA, and c) Pilot test the intervention among urban adolescents residing in an STI/HIV prevalent community. Successful completion of the mentored award will provide the requisite training to become an independent investigator with expertise in developing and evaluating digital healthcare strategies that reduce health disparities associated with STIs/HIV, give voice to a hitherto low-resourced and minoritized population, and move the United States population towards the Healthy People 2030 Goals.

PI_NAMEs: JACKMAN, KEVON-MARK PHILLIP (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Patient-facing decision support for HIV and sexually transmitted infection prevention in low-income and minority patient populations.

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Pediatric;Social Determinants of Health

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE The goal of the proposed research is to investigate how clinical genomic sequencing impacts families of pediatric patients. This research will develop an empirically informed framework of normative values important to families of pediatric patients, including ethical, legal, and social implications (ELSI), which will then be used to elicit preferences for features of sequencing from a nationally representative sample of parents in the US. The results of this work will lead to a measure of family utility that integrates ELSI and can be used in a decision analytic model to assess the impact of genomic sequencing and the importance of including family- level ELSI considerations in such analyses.

PI_NAMEs: SMITH, HADLEY STEVENS (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, DAVE J

PROJECT_TERMS: Affect;American;Area;Award;Biological;career;career development;Child;Childhood;Clinic;Clinical;clinical care;clinical implementation;clinically relevant;college;Communication;comparative effectiveness;comparative effectiveness analysis;Country;Data;Decision Making;Development Plans;diagnostic tool;economic evaluation;Effectiveness;effectiveness evaluation;Ethical Theory;ethical, legal, and social implication;Ethics;Evaluation;evidence base;exome sequencing;experimental study;Family;Family member;Family Study;follow-up;Genetic;Genetic Diseases;Genetic Screening;Genomic medicine;Genomics;Goals;Guidelines;Health;health economics;Health Policy;improved;Individual;individual patient;innovation;Insurance Coverage;Interview;Measurement;Measures;Medical center;Medical Ethics;Medical Genetics;medical schools;Medicine;Mentors;Mentorship;Methodology;Methods;Modeling;models and simulation;Nature;Outcome Assessment;Outcome Measure;Outcomes Research;Parents;Pathway interactions;Patient Preferences;Patients;pediatric patients;Pediatrics;Phase;Physicians;Policies;Policy Analysis;population health;preference;Process;professor;programs;Qualitative Research;Recommendation;Research;research clinical testing;Research Methodology;Research Personnel;Research Project Grants;Resources;Sampling;Science;screening guidelines;skills;Structure;tenure track;Testing;Training;uptake;Weight;Work

PROJECT_TITLE: An ELSI-Integrated Evaluation of the Family-Level Utility of Pediatric Genomic Sequencing

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Maternal Health;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Gestational diabetes is a common medical complication of pregnancy that annually affects ~250,000 women in the United States. Diabetes exposure during pregnancy can have long-term consequences on the health of offspring as it is associated with an increased risk of developing metabolic (obesity and type-2 diabetes) and cardiovascular diseases. The proposed research will investigate the hematopoietic alterations in offspring born to diabetic pregnancies to provide new diagnostic and therapeutic tools to mitigate the long-term negative effects of gestational diabetes on the health of adult offspring.

PI_NAMEs: REYNAUD, DAMIEN  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Adult;Adult Children;Adverse effects;Affect;Atherosclerosis;Automobile Driving;Biological Assay;Biological Markers;blood glucose regulation;Cardiovascular Diseases;Cell Compartmentation;Cell Separation;clinically relevant;Data;Development;Diabetes Mellitus;diabetic;Diabetic mouse;DNA Methylation;Early Diagnosis;Epigenetic Process;Event;Exposure to;Generations;Genetic;Gestational Diabetes;Goals;Health;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Human;Human Pathology;improved;in utero hyperglycemia;Inflammation;Knowledge;long term memory;Maintenance;medical complication;Memory;Metabolic;Metabolic stress;methylome;Modeling;Modification;Molecular;Molecular Target;Morbidity - disease rate;Mothers;mouse model;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel diagnostics;novel therapeutics;Obesity;Obesity Epidemic;offspring;Pathologic;Pathology;Pathway interactions;Pattern;Perinatal;pharmacologic;Phenotype;Population;potential biomarker;Predisposition;Pregnancy;Pregnancy Complications;Prevalence;prevent;prophylactic;receptor;receptor for advanced glycation endproducts;Receptor Signaling;Research;Risk;Role;Signal Transduction;Sterility;Testing;Therapeutic Intervention;Toll-like receptors;tool;transmission process;United States;Up-Regulation;Woman;Work

PROJECT_TITLE: Diabetic Memory in Hematopoietic Stem Cells


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Headaches;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioids;Pain Research;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke

ORG_DEPT: NEUROSCIENCES

PHR: Subarachnoid hemorrhage (SAH) causes excruciating headaches in nearly all patients during the days, weeks, or even years after the bleeding. We propose a new way to treat these severe headaches—limiting the use of opioids, which can cause addiction and have dangerous side effects—using a nerve-block procedure that has been successful in treating other types of headaches, such as migraines. If this new way of pain treatment proves successful, it could be the beginning of a huge change in how we treat pain in SAH patients, and in acute brain injury in general.

PI_NAMEs: BUSL, KATHARINA MARIA (contact);HOH, BRIAN LIM;MACIEL, CAROLINA B;SMITH, CAMERON REID

PROGRAM_OFFICER_NAME: BROWN, JEREMY

PROJECT_TERMS: Absence of pain sensation;Activities of Daily Living;Acute;Acute Brain Injuries;Acute Pain;addiction;Address;adjudication;Adult;Adverse event;Affect;Analgesics;Anesthesiology;Aneurysm;Aneurysmal Subarachnoid Hemorrhages;Bilateral;Blinded;blood product;Blood Vessels;Caring;central pain;central sensitization;cerebrovascular;Chronic Headaches;Clinical;Clinical Trials;clinically significant;Common Data Element;Complex;Conscious;Constipation;Consumption;craniofacial;Critical Care;cytokine;Dangerousness;Data;Data Coordinating Center;Depressed Level of Consciousness;Depressed mood;design;Dexamethasone;Disparity;Double-Blind Method;Enrollment;ethnic minority population;Ethnic Origin;experience;Fiber;follow-up;Fossa;Frequencies;Functional disorder;Funding;Future;Ganglia;Gastrointestinal Transit;Generations;Goals;Grant;Headache;Headache Disorders;Hemorrhage;High Prevalence;hospital readmission;Hospitalization;Hospitals;Hour;Hyperalgesia;Hypotension;improved;Individual;Inflammatory;Injections;innovation;instrument;Intervention;Intervention Studies;irritation;Knowledge;Lead;Learning;Literature;Managed Care;Massachusetts;maxillary nerve;Measures;Mediating;Meningeal;Migraine;Minority Groups;morphine equivalent;multimodality;National Institute of Neurological Disorders and Stroke;neglect;Nerve Block;neurosurgery;New York;novel strategies;novel therapeutic intervention;Numeric Rating Scale;open label;Opioid;opioid epidemic;opioid mortality;opioid sparing;opioid use;Oral;Pain;Pain intensity;Pain management;Pain Measurement;pain perception;pain reduction;Pain Research;pain score;Patients;Phase;phase III trial;placebo controlled study;Placebo Effect;prescription opioid;Procedures;Race;racial disparity;racial minority population;Randomized;Recovery;recruit;Regimen;Regulation;Research Design;respiratory;response;Risk;ropivacaine;Safety;Saline;Sample Size;Serious Adverse Event;Severities;sex;sex disparity;side effect;Site;sociodemographic factors;socioeconomics;Standardization;Subarachnoid Hemorrhage;Survivors;theories;Therapeutic;Thunderclap Headaches;Time;Ultrasonography;ultrasound;United States National Institutes of Health;Universities;Vasomotor;Vasospasm;verbal;Woman;Work

PROJECT_TITLE: Pterygopalatine Fossa (PPF) Block as an Opioid Sparing Treatment for AcuteHeadache in Aneurysmal Subarachnold Hemorrhage


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Genetics;Human Genome;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: CAMBRIDGE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE Parental care is an evolutionarily conserved behavior that is highly modulated by the sex, physiological state, and genetic background of the caregiver. An inability to properly display parental behaviors can lead to long- lasting detrimental effects in the infant. Thus, understanding the molecular basis for sex-, state-, and genetic- dependent expression of parental behavior is critical to understanding this essential behavior in normal and pathological contexts.

PI_NAMEs: LOGEMAN, BRANDON  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Adult;Advisory Committees;Affect;Alleles;Animal Behavior;Animals;ATAC-seq;Award;Behavior;behavior influence;Behavioral;behavioral outcome;biophysical properties;biophysical techniques;Biophysics;bombesin receptor subtype 3;Calcitonin Receptor;Caregivers;Caring;causal variant;Cell Nucleus;cell type;Child Rearing;Chromatin;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Data;differential expression;Electrophysiology (science);Environment;Epigenetic Process;epigenomics;Exhibits;experimental study;Fathers;Female;Future;galanin receptor;Gene Expression;gene regulatory network;Genes;Genetic;genetic approach;Genetic Screening;Genetic Transcription;genetic variant;Genetic Variation;genomic locus;Genomics;Goals;Hormones;Hour;Hypothalamic structure;Individual;Infant;Infant Care;Investments;Knowledge;Laboratories;Lactation;male;Maps;Measures;Mediating;Mentors;Molecular;Mothers;Mouse Strains;Mus;neural circuit;neuronal circuitry;Neurons;offspring;parental influence;Parents;Pathologic;Personal Satisfaction;pharmacologic;Phase;Physiological;Population;Population Control;Positioning Attribute;Preoptic Areas;Prolactin;Quantitative Trait Loci;Research;Resolution;Role;Scientist;sex;Sex Differences;sexual dimorphism;Signal Pathway;Signal Transduction;single cell analysis;single nucleus RNA-sequencing;skills;Slice;Stimulus;Testing;Testosterone;tool;Training;trait;Transcriptional Regulation;Universities;Variant;Ventricular;vesicular glutamate transporter 2;Vocational Guidance;Work

PROJECT_TITLE: Sex, Physiological State, and Genetic Background Dependent Molecular Characterization of CircuitsGoverning Parental Behavior


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Hematology;Nanotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Wound Healing and Care

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH This project is relevant to NIH’s mission as it focuses on developing a novel platelet-like-particle technology to treat bleeding and fight infection after trauma.

PI_NAMEs: BROWN, ASHLEY CARSON (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Adult;Affinity;antimicrobial;aqueous;Area;base;Binding;Biodistribution;Biological Assay;Bleeding time procedure;Blood Coagulation Disorders;Blood flow;Blood Platelets;blood product;blood-brain barrier permeabilization;Brain;Brain hemorrhage;Cause of Death;Cells;Circulation;Clinical;Coagulation Process;Contracts;controlled cortical impact;cytotoxicity;design;Dryness;Economics;Effectiveness;efficacy evaluation;Evaluation;Excretory function;Family suidae;femoral artery;Fiber;Fibrin;fighting;Gel;Goals;healing;Hemorrhage;Hemostatic Agents;Hemostatic function;high risk;Home;Homing;Immune;Immune system;Impairment;improved;In Vitro;in vivo;Incidence;Infection;infection risk;Injury;innovation;Intravenous;Keloid;Laceration;Liver;Mechanical Stimulation;Mediating;Methods;Mission;Modeling;Morbidity - disease rate;Morphology;mortality;mouse model;Multiple Trauma;Mus;nanosilver;nerve injury;neuroinflammation;novel;particle;Particle Size;Patients;Plasma;Pre-hospital setting;preclinical evaluation;Predisposition;prevent;Prognosis;Proteins;prothrombin complex concentrates;Public Health;Publishing;Rattus;Reporting;response;Rodent;Rodent Model;Safety;Saline;Site;Skin injury;systemic inflammatory response;Technology;Testing;Thrombosis;Time;tissue repair;Tissues;Transportation;Trauma;Traumatic Brain Injury;Traumatic injury;United States National Institutes of Health;wound;wound environment;wound healing

PROJECT_TITLE: Anti-microbial platelet-like-particles to treat internal bleeding and augment subsequent healing

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Precision Medicine;Urologic Diseases

ORG_CITY: NEW YORK

ORG_DEPT: UROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE This project is seeking to define the cellular and molecular events associated with resistance to immune checkpoint blockade in bladder cancer. Our preliminary data defines a gene signature emanating from myeloid cells associated with resistance to immune checkpoint blockade. Here, we will generate detailed atlases of bladder cancer which will refine our understanding of the precise myeloid cells associated with resistance, dissect the mechanistic basis for such resistance, and substantiate the clinical relevance of these observations.

PI_NAMEs: BHARDWAJ, NINA  (contact);GALSKY, MATTHEW

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Acceleration;anti-PD-1/PD-L1;anti-PD-L1 antibodies;Atlases;Automobile Driving;Binding;Biological Markers;biomarker discovery;biomarker identification;Biometry;Bladder Neoplasm;Blood;cancer type;Cell Communication;Cells;checkpoint inhibition;Clinical;Clinical Trials;clinically relevant;cohort;Computational Biology;Coupled;Data;Event;experience;Fibroblasts;Future;Genes;genetic signature;Genomics;Goals;Immune;immune checkpoint blockade;Immunologist;Immunology;Immunosuppression;Macrophage;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Mediating;Medical Oncology;Modeling;Molecular;monocyte;multidisciplinary;muscle invasive bladder cancer;Mutation;Myelogenous;Myeloid Cells;Natural Killer Cells;new therapeutic target;novel marker;Oncologist;Outcome;patient subsets;Patients;Population;Positioning Attribute;predictive marker;Qualifying;Research Personnel;Resistance;Resolution;Resources;response;Role;single-cell RNA sequencing;Specimen;T-Lymphocyte;therapeutic target;transcriptomics;Translational Research;tumor;Tumor Tissue;Urine;Urologist;Urology

PROJECT_TITLE: Dissecting myeloid cell-mediated resistance to immune checkpoint blockade in bladder cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE The purpose of the Centers for AIDS Research (CFAR) Symposium is to provide a venue to present and discuss recent advances in HIV research. This is a unique forum for presentations of the most “cutting edge” HIV research topics. The symposium provides an environment that fosters interactions between senior HIV investigators and early-stage investigators that will one day be leaders in the field.

PI_NAMEs: GANDHI, MONICA  (contact)

PROGRAM_OFFICER_NAME: GUTIERREZ, MARTIN

PROJECT_TITLE: Recent Advances in HIV Research


NIH_SPENDING_CATS: Genetics;Nutrition

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Bilateral communication between the brain and intestine, also called the “gut-brain axis”, is integral to nutrient homeostasis and similar “sensing” pathways may also exist in iron deficiency anemia. Understanding the molecules and mechanisms for how fluctuations in iron and heme levels translate into inter-organ communication and heme trafficking may lead to design of heme-based nutraceuticals to ameliorate iron-deficiency, the world’s number one nutritional disorder.

PI_NAMEs: HAMZA, IQBAL  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Ablation;absorption;Adaptor Protein Complex 3;Adaptor Signaling Protein;Afferent Neurons;Alleles;Animal Model;Animals;Aspartic Endopeptidases;Bilateral;Biological Availability;Biological Process;BMP5 gene;Brain;Caenorhabditis elegans;Cathepsin E;Cells;cofactor;Communication;Control Animal;cytotoxic;Data;Dedications;design;Diet;dietary heme;Dimensions;Distal;Ectopic Expression;EGF gene;Funding;Genes;Genetic;genetic manipulation;Genetic Models;genome-wide;Goals;gut-brain axis;Heme;Hemeproteins;heuristics;Homeostasis;Homologous Gene;Human;Hydrophobicity;in vivo monitoring;Intestinal Secretions;Intestines;Ion Channel;Ions;Iron;iron deficiency;Iron deficiency anemia;Location;Mammals;Mediating;Membrane;Metabolism;Modeling;Molecular;mutant;Neurons;novel;Nutraceutical;Nutrient;Nutrition Disorders;Nutritional;Optics;Organ;Pathway interactions;Peptide Hydrolases;Phenocopy;Potassium;Potassium Channel;protein complex;Proteins;Proteomics;Regulation;Repression;Resolution;response;RNA Interference;Role;Signal Pathway;Signal Transduction;Source;System;Technology;Tertiary Protein Structure;Testing;Tissues;trafficking;transcriptome sequencing;Translating;uptake

PROJECT_TITLE: Inter-organ signaling in heme metabolism and organismal homeostasis.

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Columbus

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE / RELEVANCE Ependymoma is the third most common malignant brain tumor in children with no effective chemotherapeutics identified to date. We propose to thoroughly investigate FACT (FAcilitates Chromatin Transcription) as a driver of the highly lethal ependymoma subtype, ZFTA-RELA. Results will offer preclinical insight into FACT as a therapeutic target and establish the efficacy of CBL0137 as rationale therapy to inform future clinical trial design for this devastating disease.

PI_NAMEs: MACK, STEPHEN C;VENERE, MONICA  (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: Accounting;Adult;Antineoplastic Agents;antitumor effect;Biological Process;blood-brain barrier penetration;Brain;Brain Neoplasms;brain tissue;Cancer Etiology;Cell Culture Techniques;Cell model;Cell Survival;Cells;chemotherapy;Childhood Brain Neoplasm;childhood cancer mortality;Chimeric Proteins;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Classification;Clinical Trials;Clinical Trials Design;clinically relevant;Combined Modality Therapy;CRISPR/Cas technology;Data;Dependence;Development;Disease;disorder subtype;Dominant-Negative Mutation;Dose;effective therapy;Ependymoma;Event;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic study;Genetic Transcription;Goals;Growth;Hippocampus;Human;Immune;immune cell infiltrate;immunoregulation;improved;in vivo;Infiltration;Inflammation;Inflammatory;insight;Knock-out;Lead;loss of function;Maintenance;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Methods;Modeling;Molecular;mouse model;Mus;Myeloid Cells;neoplastic;neoplastic cell;nerve stem cell;neurogenesis;Neuroglia;new therapeutic target;novel therapeutics;Nucleosomes;Oncogenes;Oncogenic;Pathway interactions;Patient-Focused Outcomes;Patients;Pediatric Brain Tumor Consortium;Pediatric Neoplasm;pharmacologic;phase I trial;Phenotype;pre-clinical;prevent;Prognosis;programs;Proteins;Radial;Radiation therapy;recruit;RELA gene;RNA Polymerase II;Role;self-renewal;Signal Transduction;small molecule;Solid Neoplasm;Spinal Cord;standard of care;stem;stem cell self renewal;stem cells;Subgroup;Supratentorial;survival outcome;targeted treatment;Testing;Therapeutic;therapeutic target;Transcription Elongation;transcriptome;Translating;tumor;tumor growth;tumor microenvironment;tumor progression;Tumorigenicity;Undifferentiated;United States National Institutes of Health

PROJECT_TITLE: Role of FACT in ZFTA-RelA fusion driven ependymoma

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PUBLIC HEALTH RELEVANCE STATEMENT  Understanding how the heart regulates normal systemic metabolic homeostasis is of critical importance, as its perturbation is a major source of metabolic disorders and dyslipidemia-related heart dysfunction. The Drosophila heart provides an excellent model system with which to define the molecular mechanisms that underlie functional communications between the heart and other major metabolic tissues that are essential for the maintenance of normal systemic lipid homeostasis. Our studies in the Drosophila heart system therefore represent the first step in a continuum of research that is expected to fill critical knowledge gaps in the fields of cardiac biology and energy metabolism and lay the groundwork for developing new therapeutic strategies for the amelioration of obesity and related diseases.

PI_NAMEs: LIM, HUI-YING  (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Affect;Biological Models;Biology;Blood;Cardiac;Circulation;Communication;comorbidity;Data;Diet;diet-induced obesity;Disease;Drosophila genus;Dyslipidemias;Energy Metabolism;Family;Fat Body;fly;Future;Genetic Epistasis;genetic manipulation;Genetic Screening;Heart;Hemolymph;High Fat Diet;Homeostasis;Human;Impairment;insight;knock-down;Knowledge;Link;lipid biosynthesis;lipid metabolism;Lipids;Maintenance;Mediating;Messenger RNA;Metabolic;Metabolic Diseases;Metabolism;Modeling;Molecular;Mutation;Myocardial dysfunction;novel;novel therapeutic intervention;Obesity;Organ;overexpression;Pathway interactions;Phenocopy;Process;protective effect;Protein Secretion;Proteins;Proteomics;public health relevance;Regulation;Research;Signal Transduction;Snails;Source;System;Testing;Therapeutic;thioester;Tissues;transcription factor;Transforming Growth Factor beta;Triglycerides

PROJECT_TITLE: A cardiac Wingless-Snail-Tep2 axis directs normal lipid homeostasis and protects against diet-induced obesity

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Ischemic stroke survivors represent a growing population among older adults in the U.S. and a very high-risk group for Alzheimer’s disease and related dementias (ADRD), however factors and mechanisms that contribute to preserving cognitive health and timing of dementia onset in this population remain unclear. We will examine the role of biological aging in cognitive resilience and timing of dementia onset after stroke and molecular pathways underlying this relationship through integration of state-of-the art clinical assessments of stroke and cognition over more than 15 years of follow-up with algorithmic combinations of physiological biomarkers and molecular proteomic data in diverse samples from well- established cohorts. This research will help identify novel biomarkers and molecular proteomic pathways of cognitive resilience to open up new avenues for protection of cognitive health and primary prevention of vascular dementia among ischemic stroke survivors and beyond.

PI_NAMEs: WAZIRY, REEM  (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Age;age-related disease;Aging;aging process;aging related;Algorithms;Alzheimer's disease related dementia;aptamer;Area;Autopsy;beta amyloid pathology;Biological;Biological Aging;Biological Factors;Biological Markers;Biology of Aging;biomarker discovery;Blood;Blood Tests;Brain Infarction;cardiovascular health;career;career development;Cell Physiology;Chronology;Circulation;Clinical;Clinical assessments;Cognition;Cognitive;cognitive change;cognitive function;Cognitive Therapy;cohort;cytokine;Data;Dementia;Detection;Disease;effective therapy;Ensure;Environment;Epidemiology;epidemiology study;Exhibits;experience;follow-up;Goals;Health;healthspan;high risk population;high throughput analysis;human old age (65+);human tissue;Impaired cognition;improved;Individual;Infarction;Inflammatory;Ischemia;Ischemic Stroke;Machine Learning;Measures;Medical;Mentors;Molecular;Molecular Epidemiology;Monitor;multidimensional data;multiple omics;new therapeutic target;novel marker;older adult;Outcome;Outcome Measure;Pathway interactions;Peripheral;peripheral blood;Phenotype;Physiological;Plasma;Play;Population;post stroke;post stroke dementia;preservation;Primary Prevention;Prognosis;prognostic value;Proteins;Proteome;proteomic signature;Proteomics;Research;Research Personnel;resilience;response;Risk;Role;Sampling;skills;Societies;Specificity;stressor;Stroke;stroke outcome;stroke survivor;supervised learning;System;targeted treatment;tau Proteins;Technology;Testing;Tissues;Training;Translating;Vascular Dementia;Vulnerable Populations

PROJECT_TITLE: Biological Aging, the Proteome and Cognitive Resilience among Ischemic Stroke Survivors

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Cost Effectiveness Research;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: NARRATIVE In U.S. cities, Black youth are 20 times more likely, and Hispanic youth are 4.4 times more likely, to be fatally shot than non-Hispanic White youth at ages 18-24. To prepare for a career as an independent investigator focused on eliminating racial/ethnic disparities in youth firearm violence, Dr. Jay will train in structural racism and health disparities, community-engaged research, computer simulation modeling, and economic evaluation. His research will examine the potential benefits of desegregation policies and physical investments to reduce disparities in youth firearm injuries.

PI_NAMEs: JAY, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;Adopted;Age;Area;assault;behavior change;Behavioral Sciences;Biometry;Black race;Boston;built environment;career;Cause of Death;Censuses;Cities;Communities;community engaged research;Community Health;Computer Simulation;Computers;cost;Cost Analysis;Cost Measures;Cost Savings;Coupled;Data;Desegregation;design;Development;Discrimination;Disparity;disparity reduction;economic evaluation;Economics;Ensure;Environment;Epidemiology;ethnic disparity;ethnic minority;Evidence based intervention;Exhibits;experience;Firearms;Future;Goals;Gun injury;gun violence;Health;health disparity;health equity;Health Sciences;Hispanic;Homicide;Hospitals;improved;Individual;Inequity;Injury;Intervention;Investments;Life Cycle Stages;Link;Maps;Measures;Mediating;Mental Health;Mentors;Mentorship;mid-career faculty;minority children;Modeling;models and simulation;National Institute on Minority Health and Health Disparities;Neighborhoods;Not Hispanic or Latino;novel;Outcome Measure;outreach;participatory mapping;Pathway interactions;peer;Performance;physical conditioning;Play;Police;Policies;Population;Positioning Attribute;post-doctoral training;prevent;professor;programs;protective factors;Public Health Schools;Public Policy;Race;racial disparity;racial health disparity;racial minority;Racial Segregation;Recording of previous events;Research;Research Personnel;Research Project Grants;residential segregation;Resources;Risk;Risk Factors;Schools;Science;segregation;Social Environment;Social Sciences;Strategic Planning;structural determinants;Structural Racism;Testing;Training;Trees;United States;Universities;Victimization;Violence;violence exposure;violence prevention;virtual experiments;Work;Youth

PROJECT_TITLE: Addressing structural racism to reduce racial disparities in youth firearm injuries


NIH_SPENDING_CATS: Organ Transplantation;Transplantation

PHR: Regulatory B cells (Bregs) play an important role in preventing transplant rejection and inhibiting autoimmune diseases. However, Bregs remain poorly understood. We can now directly identify these cells and determine how and where they work in vivo. Study of mice that have with a greatly increased number of Bregs will identify the factors controlling their expansion. These studies will provide critical new insight necessary to harness these potent cells to promote allograft survival.

PI_NAMEs: ROTHSTEIN, DAVID M (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Acute;Address;Agreement;allograft rejection;Allograft Tolerance;Allografting;Antibody Formation;Autoimmune;Autoimmune Diseases;Autoimmunity;B-Cell Acute Lymphoblastic Leukemia;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;Bone Marrow;Cell Count;Cell Physiology;Cells;Cellular biology;Cellular Immunity;Chronic;Consensus;cytokine;Detection;Exhibits;Experimental Autoimmune Encephalomyelitis;Frequencies;Funding;Genetic Transcription;Graft Rejection;Graft Survival;Heart Transplantation;Human;humoral immunity deficiency;Immune;Immune response;Immunity;improved;In Vitro;in vivo;Inbred Mouse;infancy;Inflammation;insight;Interleukin-10;isoimmunity;kidney allograft;Kidney Transplantation;Knowledge;loss of function;Maintenance;Mediating;microbiota;Minor;Minority;Modeling;mouse model;Mus;mutant;novel;Phenotype;Plasma Cells;Play;prevent;Process;Proteins;Regulation;Regulatory T-Lymphocyte;Reporter;Reporting;Role;Self Tolerance;Signal Transduction;System;systemic autoimmunity;T-Lymphocyte;targeted treatment;Therapeutic;transcriptome sequencing;Transplant Recipients;Transplantation;tumor;Vascular Diseases;Work

PROJECT_TITLE: In Vivo Detection And Mechanisms of Regulatory B cell Function in Transplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Antibodies have emerged as one of the most powerful and effective classes of drugs to treat a wide variety of human diseases including cancer, autoimmunity and inflammatory conditions. While much effort in the past has been devoted to engineering antibodies to recognize distinct targets, the next generation of antibodies will derive enhanced clinical efficacy from engineering efforts aimed at manipulating the manner in which antibodies engage immune receptors and the subsequent immune system reactions that they induce. Experiments proposed in this application are designed to capitalize on our growing understanding of a family of antibody-modifying enzymes in order to use them more effectively to modify antibodies in novel ways, so as to unleash the full potential of antibody drugs.

PI_NAMEs: SUNDBERG, ERIC JOHN (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Active Sites;Affect;Alanine;Animal Model;Antibodies;antibody engineering;arm;Autoantibodies;Autoimmune Diseases;Autoimmunity;Bacteria;base;Binding;Biotechnology;Carbohydrates;chemical synthesis;Chemistry;Clinical;clinical efficacy;Complement;Complex;Coupled;Cryoelectron Microscopy;Data;design;Development;Endoglycosidases;Endowment;Engineering;Enzymes;Exhibits;experimental study;Family;Future;Glycobiology;Glycoengineering;Glycoproteins;Glycoside Hydrolases;glycosylation;Health;Homologous Gene;Human;human disease;human pathogen;Hybrids;IgG Receptors;IgG1;Immune response;Immune system;Immunity;Immunoglobulin G;Immunologic Receptors;immunoreaction;immunoregulation;Immunotherapeutic agent;Inflammatory;insight;interest;Knowledge;Link;Malignant Neoplasms;Mannose;Molecular;Mutagenesis;Natural Source;next generation;novel;novel therapeutics;Pathologic Processes;Pharmaceutical Preparations;Physiological Processes;Polysaccharides;Post-Translational Protein Processing;Preparation;Property;Proteins;Rationalization;Reaction;Reagent;receptor;Reproducibility;Resolution;Role;Scanning;Site;Space Perception;Specificity;Streptococcus pyogenes;Structure;Substrate Specificity;Tertiary Protein Structure;Therapeutic;Therapeutic antibodies;therapeutic protein;tool;Variant;X-Ray Crystallography

PROJECT_TITLE: Rationalizing glycoengineering strategies for immunotherapeutic antibodies

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ORG_CITY: ANN ARBOR

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The major goal of this grant application is to determine the molecular mechanisms in which MMP1 regulate age- related skin dermal extracellular matrix (dermal aging), and the impact of these processes on the pathogenesis of many age-related skin diseases. In this application, we propose a novel concept that dermal aging process is driven by fibroblasts adaptation to deleterious surrounding ECM microenvironment. Thus, we view skin dermal aging as “outside-in adaptation”; age-related deterioration of the dermal ECM (composition, structural integrity, organization, and mechanical properties) drives cellular aging by altering ﬁbroblast spreading/mechanical force and impairing MMP1 activity.

PI_NAMEs: FISHER, GARY J (contact);QUAN, TAIHAO

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Acceleration;Affect;age effect;Age Months;age related;age related changes;age related deterioration;age-related disease;aged;Aging;aging process;aging related;Applications Grants;cancer initiation;Cell Aging;Cells;Characteristics;Clinical;Collagen;Collagen Fibril;Collagen Type I;Contusions;Cutaneous;cytokine;Data;Dermal;Dermis;Deterioration;Development;Disease;Elasticity;Elements;Enzymes;Exhibits;Extracellular Matrix;Family;Fibroblasts;Goals;Homeostasis;Human;human data;human model;humanized mouse;Immunity;Impairment;in vivo;Individual;Inflammaging;Inflammation Mediators;Inflammatory;inflammatory milieu;innovation;Interstitial Collagenase;keratinocyte;Keratinocyte cancer;Keratinocyte tumor;Knowledge;Malignant Neoplasms;Matrix Metalloproteinases;mechanical force;mechanical properties;Mediator;member;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mouse model;Mus;novel;Papilloma;Pathogenesis;Pathology;Pathway interactions;Play;Predisposition;pro-aging;Process;Production;Protein Secretion;Risk Factors;Signal Transduction;Skin;Skin Aging;Skin Cancer;skin disorder;Source;Stromal Cells;Structural Protein;Structure;targeted treatment;Testing;Therapeutic Intervention;Thinness;Transforming Growth Factor beta;Transgenes;wound healing

PROJECT_TITLE: The impact of the dermal ECM microenvironment on cutaneous aging and cancer

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Violence Research

ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Project Narrative Although research documents that adult sexual assault (ASA) is a serious public health concern that disproportionally impacts sexual minority (SM) men, we know little to date about risk and protective factors related to ASA victimization and perpetration experiences among this population as well as factors that promote or hinder adverse outcomes among SM men who experience ASA victimization. The purpose of this study is to utilize a longitudinal, prospective design to test three innovative models, inclusive of intersecting social identities , that include well-established (e.g., heavy episodic drinking), as well as population-specific (e.g., internalized homonegativity), risk and protective factors to predict (1) experiences of ASA victimization among SM men; (2) experiences of ASA perpetration among SM men; and (3) adverse outcomes among SM men who experience ASA victimization. The proposed project aligns with NIMHD’s research priorities to advance the scientific understanding of health disparities and improve minority health.

PI_NAMEs: EDWARDS, KATIE M (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Acquaintances;Address;Adult;adverse outcome;Age;Alcohol abuse;assault;binge drinking;Black race;Child Sexual Abuse;cisgender;Communities;design;Development;Discrimination;Distal;Ensure;ethnic diversity;Ethnic Origin;Etiology;experience;Forcible intercourse;Friends;Gender;gender diversity;Gender Identity;Gender Role;Geography;health disparity;Heavy Drinking;help-seeking behavior;Heterosexuals;homonegativity;improve minority health;Individual;innovation;intersectionality;Intervention;Latinx;Lesbian Gay Bisexual Transgender Queer;marginalization;Masculine;Measures;men;Methodology;Minority;Minority Status;minority stress;Modeling;National Institute on Minority Health and Health Disparities;Outcome;outcome prediction;Participant;Pathway interactions;perpetrators;Population;Predictive Factor;Prevention;Prevention program;Primary Prevention;programs;prospective;protective factors;psychological distress;Public Health;Race;racial diversity;Reaction;recruit;Reporting;Research;Research Personnel;Research Priority;revictimization;Risk;Risk Factors;Risk Reduction;Role;Sampling;Scientific Advances and Accomplishments;Self Efficacy;Sex Orientation;sexual assault;sexual coercion;sexual minority;sexual minority men;sexually active;social;Social Identification;Stress;Surveys;Testing;theories;Time;transgender men;transmasculine;Victimization;Woman;Work;young adult

PROJECT_TITLE: An Innovative, Prospective Model to Understand Risk and Protective Factors for Sexual Assault Experiences and Outcomes Among Sexual Minority Men


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE: This project will develop new methodology for improving the resolution of sodium images from the human brain. There have been approaches for generating sodium images of the brain using imaging times that are suitable for routine clinical use, however these images suffer from significant blur as a result of the demanding nature of this brain imaging application (much weaker signal than conventional MRI vanishing very quickly after it has been generated). Our approach seeks to reduce the deleterious effects of this blur through the use of anatomical information from concurrently acquired high-resolution conventional MRI scans of the brain.

PI_NAMEs: BOADA, FERNANDO E (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: Address;Advocate;Anatomy;Bayesian Method;Biochemical;Biological Markers;Brain;Brain imaging;Brain Neoplasms;Brain scan;brain tissue;Cell Nucleus;Central Nervous System;Central Nervous System Diseases;Cerebrospinal Fluid;Chronic;Clinical;clinical implementation;Clinical Protocols;clinically relevant;Communities;Coupling;Data;data acquisition;Detection;detection sensitivity;Development;Diagnosis;Energy Metabolism;Environment;Evaluation;Excision;experience;follow-up;Functional disorder;Generations;Goals;gray matter;Homeostasis;Human;human imaging;Image;image reconstruction;imaging system;improved;in vivo;Intervention;Ion Pumps;Lesion;magnetic field;Magnetic Resonance Imaging;Maps;Measures;Methodology;Monitor;MRI Scans;Na(+)-K(+)-Exchanging ATPase;Nature;neuroimaging;Noise;novel;novel strategies;Pathologic;Pathology;Patients;Performance;Positron-Emission Tomography;Property;Protocols documentation;Protons;reconstruction;Relaxation;Research;research clinical testing;Resolution;Scheme;Signal Transduction;Slice;Sodium;sodium ion;success;System;Techniques;tissue biomarkers;Tissues;Validation;white matter

PROJECT_TITLE: Anatomically Guided Sodium MRI: Accurately Monitoring Chronic Ion Pump Dysfunction in the Human Brain

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Hepatitis;Hepatitis - B;Immunization;Infectious Diseases;Liver Disease;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Hepatitis B virus is an infection that can be easily transmitted from women to newborns at the time of delivery. The REVERT-B study (Reducing Vertical Transmission of Hepatitis B in Africa) is a clinical trial designed to test a new strategy of using antiviral medication in high-risk pregnant women and newborns to reduce the risk of hepatitis B transmission. The study will measure efficacy, safety, tolerability and adherence to medication.

PI_NAMEs: DIONNE, JODIE ANN (contact)

PROGRAM_OFFICER_NAME: YATES, FRANKLIN WILLEM

PROJECT_TERMS: Address;Adherence;Adverse event;Africa;Africa South of the Sahara;Age Months;AIDS prevention;Alabama;American;Anti-viral Agents;Antigens;arm;Asia;Birth;Breast Feeding;Cameroon;China;Chronic Hepatitis B;Cirrhosis;Clinic;Clinical Trials Design;Cold Chains;college;Conduct Clinical Trials;Country;Data;Decision Modeling;design;Diphtheria-Tetanus-Pertussis Vaccine;Discipline of obstetrics;Disease;Dose;Effectiveness;effectiveness testing;efficacy testing;Eligibility Determination;Enrollment;Equipoise;experience;Flare;Follow-Up Studies;Fumarates;Goals;Guidelines;Gynecology;Health;Hepatitis B;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Transmission;Hepatitis B Vaccination;Hepatitis B Vaccines;Hepatitis B Virus;high risk;High Risk Woman;HIV;Immunoglobulins;Infant;infant infection;Infection;Infection prevention;infection rate;innovation;Intervention;Knowledge;Lamivudine;Liver diseases;Maternal and Child Health;Maternal-fetal medicine;Measures;medication compliance;Mother-to-child HIV transmission;Multi-Institutional Clinical Trial;National Institute of Child Health and Human Development;Neonatal;neonatal infection;neonate;Newborn Infant;novel;novel strategies;nucleotide analog;Oral;Outcome;Perinatal;perinatal HIV;Perinatal Infection;perinatal intervention;Perinatal transmission;Pharmaceutical Preparations;Pharmacy facility;phase III trial;Placebos;Policies;Population;Postpartum Period;Pregnancy;pregnant;Pregnant Women;prenatal;Prevalence;prevent;Prevention;Primary carcinoma of the liver cells;primary endpoint;priority pathogen;Productivity;Prophylactic treatment;Publishing;Randomized;randomized placebo controlled trial;randomized trial;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Design;Resource-limited setting;response;Risk;Risk Reduction;Role;Safety;safety assessment;Series;Social Values;Societies;standard care;standard of care;success;Tenofovir;Testing;Thailand;Time;transmission process;treatment as usual;trial design;United States;United States National Institutes of Health;Universities;Vaccinated;Vaccination;Vaccines;Vertical Disease Transmission;Vertical Transmission;Viral;Viral Load result;Virus Diseases;virus envelope;Woman;World Health Organization

PROJECT_TITLE: Reducing Vertical Transmission of Hepatitis B in Africa (REVERT-B Trial)

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Cerebrovascular;Neurosciences

ORG_CITY: MEMPHIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Acute toluene intoxication, which constitutes a worldwide public health problem, is associated with severe neurological deficits and even death driven by brain ischemia, yet the molecular targets and mechanisms involved in the brain hypoperfusion evoked by toluene remain unknown. Departing from previous work that focused on the role of neuronal ion channels in toluene intoxication, this study will identify the ion channel complex of the BK type which is present in cerebral artery smooth muscle as the target that mediates toluene- induced cerebral artery constriction, and the relative contribution of BK channel subunits and channel functional states to toluene action. This information is critical to predict the differential vulnerability of cerebral arteries that irrigate different brain areas to toluene, and the efficacy of endothelium-independent vasodilators that selectively target BK subunits to counteract toluene’s deleterious action, these agents acquiring significant potential as they will remain effective under prevalent conditions that may disrupt endothelial cerebrovascular function, such as diabetes, ageing, hypertension and stroke itself.

PI_NAMEs: BUKIYA, ANNA ;DOPICO, ALEX M. (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Ablation;Acute;Address;Affinity;Aging;animal data;Animals;Area;Arteries;base;Binding;Biological;Biotinylation;Blood;Blood flow;blood perfusion;Brain;brain circulation;Brain Ischemia;Brain region;Cells;cellular targeting;Cephalic;cerebral artery;cerebrovascular;Cerebrum;Cessation of life;Circle of Willis;clinically relevant;Complementary DNA;Complex;constriction;Coupling;Data;Diabetes Mellitus;Diameter;dimer;drug action;drug of abuse;Drug Targeting;Early Intervention;Electrophysiology (science);Electroporation;Endothelium;Engineering;Environment;Exposure to;Genetic;Human;human data;Hypertension;hypoperfusion;In Vitro;in vivo;Inhalation;Inhalation Drug Administration;interdisciplinary approach;Intoxication;Ion Channel;Irrigation;Ischemia;Knowledge;large-conductance calcium-activated potassium channels;Lead;Lipid Bilayers;Lipids;Mediating;Membrane;Metabolism;middle cerebral artery;Minor;Molecular;Molecular Target;Mus;Muscle Contraction;Neuroglia;Neurologic Deficit;Neurons;neurotoxicity;Neurotoxins;Neurotransmitters;neurovascular;novel;Organ;patch clamp;Perfusion;Pharmaceutical Preparations;pharmacologic;phenomenological models;Phenotype;Physiology;Population;Potassium Channel;Process;Proteins;Public Health;Publishing;Rattus;receptor;Recombinant DNA;Recombinants;Role;side effect;Signal Transduction;Signs and Symptoms;single photon emission computed tomography;Site;Smooth Muscle;Smooth Muscle Myocytes;Stroke;Stupor;Sudden Death;Tail;Testing;therapeutic target;Tissues;Toluene;tool;Toxicology;vapor;Variant;Vasodilation;Vasodilator Agents;voltage;Voltage-Gated Potassium Channel;Western Blotting;Work

PROJECT_TITLE: Ionic mechanisms of toluene cerebrovascular actions

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Dental, Oral, and Craniofacial Disease;Lymphatic Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PORTLAND

ORG_DEPT: DENTISTRY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Pericytes are multipotent precursor cells in human tissues, which also demonstrate tissue-specific properties in their innate differentiation potentials. Comparative transcriptomics between human pericytes of different anatomical sites identified TIAM1 as a potent regulator of cellular fate decisions. Here, we will investigate this activator of the Rho family of small GTPases as a molecular switch that determines osteogenic versus adipogenic differentiation in human pericytes.

PI_NAMEs: HSU, GINNY CHING-YUN  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Adipocytes;Adipose tissue;Anabolism;Anatomy;Animals;Area;Arthritis;Award;Bioinformatics;Biological Assay;Biology;Biometry;Blood Vessels;bone;bone cell;Bone Regeneration;bone repair;Bone Tissue;Calvaria;career;career development;cartilage regeneration;Cell Culture Techniques;Cell Differentiation process;cell preparation;Cell Therapy;Cells;Clinical;Clinical Trials;clinically relevant;Clone Cells;comparative;Course Content;craniofacial;CRISPR/Cas technology;Cytoskeleton;Data;Defect;Dental;Development;Development Plans;differential expression;Educational workshop;Elements;Family;Fatty acid glycerol esters;Future;Gene Deletion;Genes;Goals;Histology;Human;human tissue;Immunocompromised Host;Immunohistochemistry;Implant;In Vitro;in vivo;inhibitor;interest;Knock-out;knowledgebase;Lead;MCAM gene;medical schools;Mentors;Mesenchymal;Mesenchymal Stem Cells;mineralization;Modeling;Molecular;Monomeric GTP-Binding Proteins;multidisciplinary;next generation sequencing;novel;Organ;Orthodontics;osteogenic;overexpression;Pathway Analysis;Pathway interactions;Pericytes;Physiologic Ossification;Play;Population;Positioning Attribute;Postdoctoral Fellow;precursor cell;Predisposition;Property;regeneration potential;Regenerative Medicine;Regulation;Reporter;Research;research and development;Research Personnel;rho;Role;Science;Scientist;Signal Pathway;single-cell RNA sequencing;skeletal;skeletal tissue;skills;small molecule;soft tissue;Source;stem cell biology;stem cell differentiation;stem cell fate;stem cells;Techniques;Testing;Therapeutic;Thinking;TIAM1 gene;Tissue Engineering;tissue regeneration;Tissues;tomography;Training;transcriptome;transcriptomics;transdifferentiation;translational applications;Translational Research;Universities;Work;Xenograft procedure

PROJECT_TITLE: TIAM1 dictates lineage commitment in skeletal and soft tissue pericytes

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR(01)]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Immunotherapy;Nanotechnology;Women's Health Research

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative: Significance: This research is focused on the development of a new strategy for activation of therapeutics at tumor sites. This approach presents the possibility of generating active drugs only at tumor sites, reducing the off-target effects and minimizing health consequences for chemotherapy.

PI_NAMEs: ROTELLO, VINCENT M. (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: 4T1;Cancer Biology;cancer cell;cancer therapy;catalyst;Cells;Chemistry;chemotherapy;Coculture Techniques;Coupled;Cytoprotection;Development;Dyes;efficacy evaluation;Elements;Encapsulated;Engineering;fabrication;fluorophore;Generations;Goals;Health;Immunology;In Situ;In Vitro;in vitro activity;in vivo;in vivo evaluation;Injections;Ligands;Macrophage;Malignant Breast Neoplasm;Mannose;mannose receptor;Mass Spectrum Analysis;Modeling;Modification;monolayer;mouse model;Mus;nanoGold;nanomaterials;nanoparticle;nanotherapeutic;nanovector;neoplastic cell;orthotopic breast cancer;particle;Pharmaceutical Preparations;Phenotype;Play;Porphyrins;pre-clinical;Process;Prodrugs;Research;Role;scaffold;Serum;Site;Specificity;Structure;System;targeted delivery;targeted treatment;Therapeutic;Transition Elements;Treatment Efficacy;tumor;Tumor-associated macrophages;uptake;Validation

PROJECT_TITLE: Targeting of Bio-orthogonal Chemotherapeutic Nanozymes to Tumor-Associated Macrophages

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Telehealth

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE This project will measure the relationship between telemedicine adoption by skilled nursing facilities and clinical outcomes among their residents with dementia, as well as characterize the factors associated with different patterns of telemedicine use by SNFs with claims and survey data. Results from this proposal will inform how Medicare and state Medicaid programs should regulate and promote telemedicine use in these settings. Our findings will also help guide clinicians who care for residents with dementia on the clinical impact associated with telemedicine use and how it is being used nationally, both of which address NIA's mission of improving the health and well-being of older Americans for those residing in nursing homes.

PI_NAMEs: BARNETT, MICHAEL LAWRENCE (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Accident and Emergency department;Address;Administrator;Adopted;Adoption;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;Caring;Characteristics;Clinical;cost;COVID-19;COVID-19 mortality;COVID-19 pandemic;Data;Data Set;Dementia;Diagnosis;Disparity population;Drops;Emergency department visit;Geriatric Psychiatry;Goals;Health;Healthcare;Home Nursing Care;Hospitalization;hospitalization rates;Hour;implementation barriers;implementation strategy;improved;improved outcome;Individual;innovation;Institutionalization;Knowledge;Leadership;Literature;Logistics;Measures;Medicaid;Medical;medical specialties;Medicare;Medicare claim;Mission;Modeling;Neurology;novel coronavirus;Nursing Homes;older adult;Outcome;pandemic disease;Patient Transfer;Patients;Pattern;Perception;Personal Satisfaction;Persons;Physician Executives;Physicians;Policies;Population;programs;Provider;Psychiatry;Reporting;Rural;Sampling;Services;Site;Skilled Nursing Facilities;Surveys;Telemedicine;Vaccines;Visit;Vulnerable Populations

PROJECT_TITLE: The Use of Telemedicine in the Care of Nursing Home Residents with Alzheimer's Disease and Related Dementias During and After the COVID-19 Pandemic

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]