NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative This application proposes to isolate neutralizing monoclonal antibodies from the plasma of Zika virus recovered individuals that have been generated from long-lived bone marrow plasma cells, and for the first time, compare the lineages and viral targets of B cell generated antibodies from both circulating and marrow compartments. In addition to this novel work with Zika virus, this proposal will identify broadly neutralizing dengue virus antibodies from the plasma of individuals infected with two different dengue viruses which will inform vaccine design and have the potential to be developed as pan-dengue therapeutics. This award is thus primed to identify a potential paradigm shift in our understanding of the mechanisms by which human B cells develop, mature and respond in acute viral infections.

PI_NAMEs: MARKMANN, ALENA JANDA (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute;adaptive immune response;adaptive immunity;Adult;Affect;Antibodies;Antibody Response;Antibody-mediated protection;Antigens;Applications Grants;Appointment;Area;Award;B-Lymphocytes;Binding;Binding Sites;Biological Assay;Bone Marrow;career;career development;Cell Separation;Cells;Cellular Assay;Child;Clinical;Clone Cells;complementarity-determining region 3;congenital zika syndrome;convalescent plasma;Cross Reactions;cross reactivity;Culicidae;Dengue;Dengue Hemorrhagic Fever;Dengue Infection;Dengue Virus;design;design and construction;Development;dimer;Disease;E protein;epidemic virus;Epidemiology;Epitopes;experience;experimental study;Exposure to;Fever;Flavivirus;Flavivirus Infections;Foundations;glycosylation;Hemorrhagic Shock;high resolution imaging;Human;Immune;Immune response;Immunity;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;Immunology;improved;Individual;Infection;Instruction;Investigation;Ions;Japanese encephalitis virus;Joints;Knowledge;Latin America;Life;Manuscripts;Maps;Marrow;medical schools;Medicine;Memory B-Lymphocyte;Mentors;Methods;Microbiology;Molecular;Monoclonal Antibodies;Morbidity - disease rate;neutralizing antibody;neutralizing monoclonal antibodies;new technology;North Carolina;novel;Pathogenicity;Peptides;Plasma;Plasma Cells;polyclonal antibody;Polysaccharides;Population;professor;Proteins;Proteomics;Publications;recombinant virus;Recombinants;Research;Resolution;response;RNA Viruses;Role;Scientist;screening;secondary infection;Serology;Serotyping;Serum;Site;skills;Structure;Syndrome;Technology;tenure track;Tertiary Protein Structure;Therapeutic;tick transmission;Time;tool;Training;transmission process;United States National Institutes of Health;Universities;Vaccine Design;vector mosquito;vector-borne;Viral;Viral Hemorrhagic Fevers;Virus;virus development;Virus Diseases;Virus Replication;West Nile;Work;Writing;Yellow Fever;ZIKA;Zika Virus;ZIKV infection

PROJECT_TITLE: Defining Molecular Epitopes of Protective Antibodies to Flaviviruses

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Biological interfaces between infectious microbes and their hosts are enriched for bouts of rapid and volatile evolution. In this proposal, we investigate the evolutionary consequences of host- microbial interactions. The work is revealing new antiviral and antimicrobial functions, which might be developed as new interventions to combat infectious diseases.

PI_NAMEs: ELDE, NELS C. (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Antibiotics;Antibodies;antimicrobial;Bacteria;Bacteriophages;Biological;Biological Models;Biology;Cell Physiology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Communicable Diseases;Complex;computational pipelines;Computer Analysis;Conflict (Psychology);Dedications;Diarrhea;DNA Restriction Enzymes;DNA Viruses;Endosomes;enteric pathogen;Equilibrium;Evolution;experimental analysis;Genes;Genetic;Genome;host-microbe interactions;Immune;immune function;Infection;innovation;Intervention;Intestines;Mammals;Microbe;microbial genome;microbial host;Modernization;multidisciplinary;novel;pathogenic microbe;Pathway interactions;Peptides;Process;Proteins;Recording of previous events;Research;Retrotransposon;Role;Scheme;Selfish Genes;Signal Transduction;Sorting;System;Time;tool;Transcript;Vaccinia virus;Variant;Viral;Viral Genome;Viral Physiology;Virion;Virus;Volatilization;Water;Work

PROJECT_TITLE: Evolutionary innovations from host-microbe interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Many brain disorders result from disruption of genes that regulate cell-cell communications during neural circuit assembly. We are studying genes encoding cell-surface proteins that play important roles in cell-cell communications during dendrite morphogenesis and axon target selection. Understanding how these proteins work will contribute to our understanding of the pathogenesis of brain disorders resulted from disruptions of cell-cell communications.

PI_NAMEs: LUO, LIQUN  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Adult;alpha-latrotoxin receptor;Axon;Binding;Biological;Brain;Brain Diseases;Brain region;candidate identification;Cell Communication;Cell surface;Cell Surface Proteins;cell type;Cells;Complement;Complex;Dendrites;Development;Distal;Distant;Drosophila genus;entorhinal cortex;Etiology;experimental study;G Protein-Coupled Receptor Signaling;Genes;Genetic;genetic manipulation;Grant;Growth Cones;GTP-Binding Proteins;Hippocampus;Horseradish Peroxidase;Human;Hypothalamic structure;Individual;insight;Label;Lateral;Ligands;Mass Spectrum Analysis;Medial;Mediating;Mental disorders;Methods;mitral cell;model organism;Morphogenesis;mosaic analysis;Mus;Nervous System;Nervous System Disorder;neural circuit;Neurobiology;neurodevelopment;neuromechanism;Neurons;novel;olfactory bulb;Olfactory Pathways;Output;Pathogenesis;Pattern;Play;postsynaptic;presynaptic;Presynaptic Terminals;Process;Proteins;Proteome;Proteomics;Purkinje Cells;receptor;Resolution;Role;Signaling Protein;spatiotemporal;Specificity;Surveys;Synapses;Technology;Thalamic structure;Time;tool;Trees;virus genetics;Work

PROJECT_TITLE: Cell-cell communications in neural circuit assembly

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Rehabilitation;Rehabilitation;Sleep Research;Stroke

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Given the critical role of sleep in enhancing neural recovery, motor learning, neuroprotection, and neuroplasticity, interventions to enhance sleep that target sleep could improve recovery and rehabilitation outcomes for stroke patients. In this proposal, a multidisciplinary group of researchers with expertise in rehabilitation medicine, sleep medicine, nursing, physical therapy, wearable technologies, and implementation science will adapt, implement and evaluate a state-of-the-art intervention to promote sleep for stroke patients undergoing acute rehabilitation. SIESTA-Rehab, adapted from a previous unit-based intervention, bundles two sleep-promoting interventions to address the unique sleep challenges stroke patients face during acute rehabilitation: (1) nursing education and empowerment to reduce unnecessary disruptions; (2) a systematic protocol to screen, diagnose, and treat sleep-disordered breathing if present during acute stroke rehabilitation.

PI_NAMEs: ARORA, VINEET  (contact);JAYARAMAN, ARUN

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Academy;actigraphy;Acute;acute stroke;Address;Adult;American;Area;behavioral economics;Biometry;Bionics;Care given by nurses;Chicago;Clinical;Clinical Data;Clinical Nurse Specialists;Communication;Deglutition;design;Development;Diagnosis;Discipline of Nursing;Dose;Early Intervention;effectiveness evaluation;effectiveness study;empowerment;Energy Metabolism;Exercise Tolerance;experience;Face;Floor;functional independence;Funding;Gait;heart rate variability;high risk;Home;Hospitalization;Hospitals;implementation science;improved;improved outcome;improvement on sleep;indexing;Inpatients;Interruption;Intervention;Judgment;Learning;Left;Long term disability;Measures;Medical;Medicine;Monitor;motor learning;Movement;multidisciplinary;multimodality;Natural experiment;neural;Neuronal Plasticity;neuroprotection;novel;Nurses;Nursing Education;Outcome;Patient Admission;Patients;Performance;performance based measurement;Pharmaceutical Preparations;Physical activity;Physical Function;Physical Medicine;Physical Rehabilitation;Physical therapy;Protocols documentation;Publishing;Random Allocation;Recommendation;Recovery;Rehabilitation Outcome;Rehabilitation therapy;Reporting;Research Personnel;Resolution;Risk;Role;screening;sensor;skills;Sleep;Sleep Apnea Syndromes;Sleep disturbances;sleep quality;Speech;Stroke;stroke patient;stroke recovery;stroke rehabilitation;Surveys;Survivors;Symptoms;Testing;theories;Translational Research;treatment as usual;United States National Institutes of Health;Universities;Validation;Visit;Walking;wearable device;wearable sensor technology;Work;Wrist

PROJECT_TITLE: SIESTA (Sleep of Inpatients: Empower Staff to Act) for Acute Stroke Rehabilitation - Resubmission 01

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Diabetes;Emerging Infectious Diseases;Infectious Diseases;Obesity;Pediatric

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: MHC II proteins bind peptides and present them to T cells as part of the system by which the immune system surveys the body for infection or malignancy. The major long term goal of our study is to determine how the set of MHC II-presented peptides changes during pathological conditions such as Diabetes and Metabolic Syndrome.

PI_NAMEs: SANTAMBROGIO, LAURA  (contact);STERN, LAWRENCE J.

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Adolescent;Affect;Affinity;Age;analysis pipeline;Antigen Presentation Pathway;antigen processing;Antigen-Presenting Cells;Antigens;Autoantigens;autoreactive T cell;Binding;Binding Proteins;Biochemical;carbonyl group;Cathepsins;CD4 Positive T Lymphocytes;chemical group;Chronic Childhood Arthritis;cytokine;Data;data acquisition;Dedications;Detection;Diabetes Mellitus;diabetic patient;Disease;Endosomes;Environment;Epitopes;experimental study;glycation;Goals;Haplotypes;high throughput analysis;Hot Spot;Human;Hyperglycemia;Immune response;Immune system;Immunity;Immunization;immunogenicity;Immunologics;In Vitro;Infection;Insulin;Insulin-Dependent Diabetes Mellitus;Interferon Type II;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measures;Metabolic stress;Metabolic syndrome;Modification;mouse model;Multiple Sclerosis;neoantigens;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;Oxidation-Reduction;Oxidative Stress;pathogen;Pathologic;Pathway interactions;Patients;Pattern;Peptides;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Play;Population;Positioning Attribute;Post-Translational Protein Processing;Prealbumin;Predisposition;Process;Production;Proliferating;protein aminoacid sequence;Proteins;Proteomics;Role;Salmonella typhimurium;Sampling;sex;Stains;sugar;Surface;Surveys;System;T-Lymphocyte;tandem mass spectrometry;TNF gene

PROJECT_TITLE: Effects of Glycation and Carbonylation on MHC II-restricted immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(02)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NEW HAVEN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposal main goal is to investigate the contribution non-coding RNAs and sterol intermediates and derivatives in the regulation of vascular metabolism and immune functions in atherosclerosis. This work will provide critical insight into fundamental regulatory mechanisms and will pave the way to the identification of innovative therapeutic strategies to treat atherosclerosis.

PI_NAMEs: SUAREZ, YAJAIRA  (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Affect;Atherosclerosis;Blood Vessels;Cardiovascular Diseases;Cells;Cholesterol;Chronic Disease;Disease Progression;Down-Regulation;Endothelial Cells;Exposure to;fatty acid oxidation;Foam Cells;Genes;Glycolysis;Goals;Homeostasis;Immune;immune function;Immune signaling;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;innovation;insight;Link;lipid metabolism;Lipids;Literature;Macrophage;Macrophage Activation;Mesenchymal;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;MicroRNAs;Molecular;Phenotype;Play;Process;programs;Reaction;Regulation;Research;response;Role;Shapes;Signal Pathway;Smooth Muscle Myocytes;Sterols;Therapeutic;therapeutic target;Untranslated RNA;Vascular Diseases;vascular inflammation;Work

PROJECT_TITLE: Insights into the molecular mechanisms regulating vascular and immune metabolism in vascular diseases


NIH_SPENDING_CATS: Biotechnology;Genetics

PHR: Our group studies the mechanism of meiotic recombination. Defects in meiotic recombination cause chromosome segregation errors during formation of eggs and sperm that lead to birth defects and miscarriage. In addition, meiotic recombination is closely related to mitotic recombinational DNA repair, a process that prevents cancer.

PI_NAMEs: BISHOP, DOUGLAS K (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Architecture;Biochemical;Cells;Chromatids;Chromosome Pairing;Chromosome Segregation;Complement;Congenital Abnormality;Defect;Detection;DNA;DNA Double Strand Break;DNA Repair;DNA Sequence;Double Strand Break Repair;egg;Ensure;Enzymes;Event;Frequencies;Genetic Recombination;Genetic Techniques;Goals;homologous recombination;Human;Hybrids;Invaded;light microscopy;Malignant Neoplasms;Mediating;Meiosis;Meiotic Recombination;Methods;Mitosis;Mitotic;Mitotic Recombination;Molecular;Molecular Genetics;Organism;Play;prevent;Process;protein protein interaction;Proteins;Rad51 recombinase;recombinase;recombinational repair;reconstitution;Role;Saccharomycetales;Sequence Homology;Sister Chromatid;sperm cell;Spontaneous abortion;tool;ultra high resolution

PROJECT_TITLE: Mechanism of Dmc1-mediated Meiotic Recombination in Budding Yeast


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Mental Health;Neurosciences;Stroke

ORG_CITY: Aurora

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Cognitive impairment following stroke is emerging as one of the leading causes of disability in the country. Despite large research efforts, there are currently no approved pharmacotherapies for improving functional outcomes following stroke. This proposal aims to uncover molecular mechanisms underlying stroke-induced synaptic and cognitive deficits to identify potential molecular targets for pharmacologic intervention.

PI_NAMEs: BURCH, AMELIA  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;Address;Adenosine Diphosphate Ribose;Affect;Animal Model;Astrocytes;Attention;Behavioral Assay;Biological Assay;Brain;Brain region;calmodulin-dependent protein kinase II;Cations;Cause of Death;Cell model;cell type;Cells;Central Nervous System;Cerebral Ischemia;Chronic;Clinical Trials;Cognitive;Cognitive deficits;cognitive disability;cognitive load;cognitive process;Country;Data;Dementia;disability;Electrophysiology (science);Endothelium;Ensure;executive function;Exhibits;experience;Family;functional improvement;Health;Healthcare Systems;Hippocampus;Human;Image;Immunofluorescence Immunologic;Impaired cognition;Impairment;improved;In Vitro;in vivo;Infarction;inhibitor;Injections;Intervention;Ion Channel;Ischemia;ischemic injury;Ischemic Stroke;Knock-out;Knockout Mice;Language;Learning;Ligands;Long-Term Potentiation;Measures;Memory;Memory impairment;Microglia;middle cerebral artery;Middle Cerebral Artery Occlusion;mild cognitive impairment;Modeling;Molecular;Molecular Target;molecular targeted therapies;mortality risk;mouse model;Mus;neural network;Neural Pathways;neurobehavioral;Neurologic;Neurons;neuroprotection;neurorestoration;novel;novel therapeutic intervention;Oxidative Stress;Pathology;Pathway interactions;patient population;Patients;pharmacologic;Pharmacotherapy;Phenocopy;post intervention;post stroke;preservation;Procedures;receptor;Recovery of Function;Reperfusion Therapy;Research;restoration;Role;sex;Short-Term Memory;Signal Transduction;Slice;Source;Stroke;Survivors;Symptoms;Synapses;synaptic function;Synaptic plasticity;Therapeutic Intervention;Thrombolytic Therapy;treatment strategy;United States;Up-Regulation

PROJECT_TITLE: CD38 activation of TRPM2 in hippocampal neurons contributes to stroke-induced cognitive dysfunction


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARATIVE Medulloblastoma (MB) is the most common malignant brain tumor in children and group 3 MB has the worst overall outcome. Current therapy is infective and highly toxic. We have identified WEE1 as a therapeutic target in MB and now propose to examine resistance mechanisms to WEE1 inhibitors.

PI_NAMEs: VIBHAKAR, RAJEEV  (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: Apoptotic;BRCA2 gene;C-terminal;Cell Line;Cell Survival;Cells;Cerebellum;Chemicals;chemotherapy;Chemotherapy and/or radiation;Childhood;Chromatin;Classification;Clinical;clinical development;Clinical Trials;clinically relevant;Data;DNA Damage;DNA Polymerase II;DNA Repair;Dose;Enhancers;Epigenetic Process;Exhibits;Future;gemcitabine;Genetic;Genetic Recombination;Genetic Transcription;Genomics;Goals;Heterogeneity;high risk;homologous recombination;Hypoxia;In Vitro;in vivo;Induction of Apoptosis;inhibitor;insight;Knowledge;leukemia;Link;Maintenance;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Mediator;Medulloblastoma;Metabolic Pathway;Morbidity - disease rate;mouse model;Neoplasm Metastasis;neoplastic cell;Neurosphere;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;PARP inhibition;patient derived xenograft model;Patients;Pediatric Neoplasm;Phosphorylation;Poly(ADP-ribose) Polymerase Inhibitor;Population;pre-clinical;Prognosis;Radiation therapy;replication stress;Repression;Research;Resistance;resistance mechanism;response;RNA;RNA interference screen;Role;Sampling;screening;SHH gene;Signal Transduction;small molecule inhibitor;stem-like cell;Stress;Subgroup;success;synergism;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic target;therapeutically effective;therapy resistant;Transcription Initiation;Transcriptional Regulation;transcriptional reprogramming;Translations;Treatment Efficacy;tumor;Validation;Work;Xenograft procedure

PROJECT_TITLE: Mechanisms of resistance to WEE1 inhibition in Myc driven medulloblastoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: LM

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative This project investigates how the violent historical legacy of the U.S. medical examiner/coroner system offers insights into why state sanctioned autopsies conducted for people of color killed during police encounters often fail to align with calls for social justice.

PI_NAMEs: KEEL, TERENCE D (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Accountability;American;Autopsy;Black Populations;Black race;Book Reviews;Books;Cessation of life;Cities;Colonialism;Color;Communities;community violence;Comparative Study;Coroners and Medical Examiners;Country;County;Data;development policy;Federal Government;Image;Imprisonment;insight;Intervention;Latinx population;Law Enforcement;Laws;Legal;Legal Intervention;Los Angeles;Medical Examiners;Michigan;Microfilm;migration;Monograph;mortality;Murder;Native-Born;Peer Review;people of color;Play;Police;policy recommendation;Politics;Public Health;Racial Segregation;Recording of previous events;Reporting;Research;Role;Science;segregation;Series;Social Justice;System;Treaty;United States;Violence;Virginia;Work

PROJECT_TITLE: A Comparative Study of Medical Examiner/Coroner Offices in the United States


ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Cerebral aneurysms are weakened bulges in arteries in the brain that, if they tear, can cause brain damage or death. We believe that this weakening is due in part to changes in the tissue that makes up the aneurysm and that these changes can be indirectly determined using computational models. This project aims to both measure the key properties of surgically removed aneurysms and develop the models that will be able to predict those properties in intact aneurysms, allowing prediction of future tearing that can be used to guide clinical management of cerebral aneurysms.

PI_NAMEs: ALFORD, PATRICK W (contact)

PROJECT_TERMS: Address;Aneurysm;Architecture;Arteries;Behavior;Biophysical Process;Blood flow;Brain;Brain Death;Brain Injuries;Cadaver;Cells;Cerebral Aneurysm;cerebral artery;Circle of Willis;Clinic;Clinical;Clinical Management;Clip;Collagen;Complex;Computer Analysis;Computer Models;Early Intervention;Experimental Models;extracellular;Extracellular Matrix;Failure;Future;Geometry;global environment;Growth;Heterogeneity;Human;in vivo;insight;Intervention;Invaded;Liquid substance;Macrophage;Maps;Measurable;Measures;mechanical behavior;mechanical properties;Mechanics;Mediating;Methods;Modeling;Morphology;next generation;novel;Operative Surgical Procedures;Patients;predictive modeling;predictive tools;pressure;Process;Property;repaired;Risk;Role;Rupture;Ruptured Aneurysm;Sample Size;Sampling;Scanning;Series;Shapes;shear stress;Stress;Stroke;Structure;Survival Rate;Testing;Theoretical model;Time;Tissue Donors;Tissues;tool development;Unnecessary Surgery;Vasospasm

PROJECT_TITLE: Role of mechanical heterogeneity in cerebral aneurysm growth and rupture

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: In neurons, immediate-early gene transcription factors (IEG-TFs) are expressed in response to depolarization and regulate genes that modify synaptic and cellular function. It is unknown how IEG-TFs disambiguate depolarization that arises from action potentials and synaptic potentials to elicit specific changes in synaptic connectivity. We propose to use electrophysiology, optical, and genomic techniques to investigate how the IEG-TF NPAS4 transforms action potentials and synaptic potentials into gene regulation that drives plasticity of specific synapse populations.

PI_NAMEs: BLOODGOOD, BRENDA L (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: 5' Untranslated Regions;Action Potentials;Acute;Address;Anatomy;Animals;Apical;autism spectrum disorder;Behavior Control;Binding;Biology;Brain Diseases;Calcium Channel;Cell Nucleus;Cell Physiology;Cells;ChIP-seq;Complex;Cyclic AMP;Data;Dendrites;Electrophysiology (science);Epilepsy;Equilibrium;Excitatory Postsynaptic Potentials;experimental study;Frequencies;Gene Expression;Gene Expression Regulation;Gene Modified;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Genomics;Glutamates;Goals;Growth Factor;hippocampal pyramidal neuron;Hippocampus;Immediate-Early Genes;in vivo;Inhibitory Synapse;insight;Lead;Life;Location;Mechanics;Membrane;Mental disorders;Messenger RNA;Methods;Molecular;Monitor;Mus;N-Methyl-D-Aspartate Receptors;Nervous System Disorder;Neurodevelopmental Disorder;neuron component;neuronal cell body;Neurons;neurotrophic factor;NPAS4 gene;Optics;Output;Pattern;Phenotype;Population;Preparation;prevent;programs;Proteins;Recording of previous events;recruit;Regulation;response;Schizophrenia;segregation;Signal Transduction;Slice;spatiotemporal;stem;Stimulus;Synapses;synaptic function;Synaptic plasticity;Synaptic Potentials;Techniques;Testing;tool;Training;transcription factor;Transcriptional Regulation;Translating;Translations;Work

PROJECT_TITLE: Molecular and Cellular Mechanisms Underlying Activity Dependent Gene Regulation in Neurons

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The association between pediatric myelodysplastic syndromes (MDS) and monosomy 7 and germline gain of function (GoF) SAMD9/SAMD9L mutations has been made recently, but the molecular and functional consequences of these mutations in hematopoietic cells are not well understood. Furthermore, in many cases additional somatic revertant genetic changes occur that result in hematopoietic recovery. The proposed studies will use an iPSC model system and primary patient samples to characterize the molecular and functional consequences of GoF SAMD9/9L mutations and to describe the resultant clonal architecture and evolution.

PI_NAMEs: SCHWARTZ, JASON ROSS (contact)

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: Advisory Committees;alanine aminopeptidase;Alleles;ANXA5 gene;Apoptosis;Architecture;Ataxia pancytopenia;Autophagocytosis;Award;Biological Models;Bone Marrow Diseases;career;career development;Caspase;CD34 gene;Cell Count;Cell Cycle Arrest;Cell Line;Cell Separation;Cells;Cellular Assay;Childhood;Chromosome 7;chromosome 7 loss;Chromosome Deletion;Chromosomes;Clinical;clinical phenotype;Clonal Evolution;cohort;CRISPR/Cas technology;cytotoxic;Data;Development;Development Plans;Diagnosis;differential expression;differentiation in vitro;Disease;Dysmyelopoietic Syndromes;Educational workshop;Ensure;Evolution;experience;Faculty;Flow Cytometry;gain of function;gain of function mutation;Genes;Genetic;Genome engineering;genome sequencing;Germ Lines;Germ-Line Mutation;Goals;Hematologic Neoplasms;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Heterozygote;Hypocellular Bone Marrow;improved;in vivo;induced pluripotent stem cell;Inhibition of Cell Proliferation;insight;Institution;Interferon alpha;Interferons;K-Series Research Career Programs;Lead;lectures;Lesion;Location;Malignant Neoplasms;Maps;Mentors;MIRAGE syndrome;Modeling;Molecular;Monosomy 7;mutant;Mutate;Mutation;Myelogenous;Myeloid Cells;Myelopoiesis;Myeloproliferative disease;Neoplasms;Nucleotides;Outcome;Output;Pathogenesis;Pathologic;Pathway interactions;Patients;Pediatric Hematology;pediatric myelodysplastic syndrome;Phenotype;Physicians;pressure;Prognosis;Proteins;Publishing;Recovery;repaired;Reporting;Research;Research Support;Resolution;Resource Sharing;Saint Jude Children's Research Hospital;Sampling;Scientist;senescence;Series;single cell genomics;skills;Somatic Mutation;Stains;stem;stem cell model;stem cells;success;Syndrome;Time;tool;transcriptome sequencing;Uniparental Disomy

PROJECT_TITLE: Hematopoietic consequences of gain-of-function SAMD9 and SAMD9L mutations

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE To design better malaria vaccines, we propose to learn from nature by studying immune responses against the malaria parasite in people who have developed protection against the disease as a result of life-long exposure. This project will compare antibodies from malaria-protected and susceptible individuals to determine the characteristics of antibodies that a malaria vaccine should elicit. In addition, antibodies that are able to strongly inhibit the parasite will be analyzed in more detail to serve as a blueprint for malaria vaccine design.

PI_NAMEs: BUNNIK, EVELIEN MARGARETHA (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: acquired immunity;Adult;Affinity;Antibodies;Antibody Response;Antibody-mediated protection;Antigens;B cell differentiation;B-Cell Antigen Receptor;B-Cell Development;Binding;Biological Assay;Blood;Cell Lineage;Cessation of life;Characteristics;Child;Clinical;cohort;Complex Mixtures;Data;design;Disease;Epitope Mapping;Epitopes;Erythrocytes;experience;experimental study;Failure;falls;fighting;Freezing;Genes;Genetic Polymorphism;Genetic Variation;Immune;Immune response;Immunity;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin M;Immunoglobulin Somatic Hypermutation;Immunologics;Immunology;In Vitro;Individual;Infection;insight;Invaded;Knowledge;Learning;Life Cycle Stages;Malaria;malaria transmission;Malaria Vaccines;Maps;Mass Spectrum Analysis;Memory;Memory B-Lymphocyte;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mutagenesis;Nature;next generation;novel;Parasites;Parasitology;Passive Immunization;Peripheral Blood Mononuclear Cell;Persons;Plasma Cells;Plasmodium falciparum;Positioning Attribute;Predisposition;prevent;Proteomics;response;Reverse engineering;Serology;Serum;Sporozoite vaccine;Sporozoites;structural biology;Structure;Testing;tool;Transcend;Uganda;Vaccination;vaccine candidate;Vaccine Design;vaccine development;vaccine trial;Vaccines;Variant;X-Ray Crystallography

PROJECT_TITLE: Defining conserved epitopes on polymorphic malaria antigens

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: VELLORE

ORG_COUNTRY: INDIA

ORG_FIPS: IN

ORG_NAME: CHRISTIAN MEDICAL COLLEGE

PHR: PROJECT NARRATIVE  Community-wide deworming to significantly reduce and/or break transmission of soil-transmitted helminths in endemic populations can reverse the effects of these infections on host immune responses. In this study, the effect of large-scale, community-wide deworming with albendazole, on the changes to hookworm-modulated host immune response and protective immunity to bystander antigens (tuberculosis and vaccines) will be studied, in both adults and children and furthermore, whether this effect will be sustained in the post deworming period will also be studied. This study will demonstrate the potential additional benefits of deworming and is of particular importance to communities with a high burden of hookworm infection.

PI_NAMEs: AJJAMPUR, SITARA SWARNA RAO (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: 3 year old;Adult;Adverse event;Affect;Albendazole;Anemia;Anthelmintics;Antigens;Area;Ascaris lumbricoides;Attenuated;Award;Bystander Effect;career;Cells;Child;Cluster randomized trial;Cognition;cohort;Cohort Studies;Communicable Diseases;Communities;cytokine;data visualization;Defecation;Diphtheria;Diphtheria Toxoid;early childhood;Ecuador;Epidemiology;experience;Female of child bearing age;Flow Cytometry;follow-up;Frequencies;Goals;Haemophilus influenzae;helminth infection;Helminths;Homeostasis;Hookworm Infections;Hookworms;human disease;Immune;Immune response;immune system function;Immunity;Immunoassay;Immunoglobulin G;Immunologics;immunoregulation;implementation science;improved;India;Infant;Infection;infection rate;Infectious Disease Epidemiology;Influenza B Virus;Interferon Type II;Interleukin-10;Interleukin-12;Interleukin-13;Interleukin-4;Interleukin-5;Interruption;Intervention;Iron;Journals;Laboratories;laboratory experience;low and middle-income countries;Malaria;Manuscripts;mathematical model;Measures;medical schools;Mentors;Mentorship;Meta-Analysis;Morbidity - disease rate;Mothers;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;Necator americanus;neglect;Nursery Schools;Old World Hookworm;Parasites;Parasitic Diseases;Parasitic infection;pathogen;pathogenic bacteria;pathogenic virus;Performance;Persons;Pertussis;Peru;Pharmaceutical Preparations;Plasma;Policies;Population;postnatal period;Pregnant Women;prenatal;Prevalence;programs;Public Health;public health priorities;Publishing;Qualitative Research;Recommendation;recruit;Regression Analysis;Regulatory T-Lymphocyte;Research;Research Design;research facility;Research Methodology;response;Role;Running;Sampling;Sanitation;Schistosomiasis;School-Age Population;Schools;Site;skills;Soil;standard of care;Statistical Data Interpretation;systematic review;targeted treatment;Testing;Time;TNF gene;tool;Training;Transforming Growth Factor beta;Translating;transmission process;Treatment Efficacy;Trichocephalus trichiura;Tuberculosis;Uganda;United States National Institutes of Health;Vaccination;vaccine immunogenicity;vaccine response;Vaccines;vaccinology;Work

PROJECT_TITLE: Effect of Community Wide Deworming on Hookworm Modulated Immune Responses to Bystander Antigens and Vaccines in Southern India

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDA-A(90)S]


NIH_SPENDING_CATS: Digestive Diseases;Immunotherapy

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Our proposed studies are relevant to public health, particularly to inflammatory bowel diseases and their extra- intestinal manifestations which generate patient suffering and major national healthcare costs. Our research aim is to understand Treg-mediated immune tolerance in the large intestine and to lay the ground work to identify and develop new immunotherapy strategies to treat autoimmune diseases.

PI_NAMEs: KIM, SANGWON VINCENT (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: absorption;Antigens;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Autoimmune Diseases;Binding Sites;CCR9 gene;Celiac Disease;Cell Separation;Cells;Chemicals;ChIP-seq;Chromosome 10;Circulation;Colitis;Cues;Data;Diet;dietary;engineered T cells;Ensure;Event;Exposure to;Extravasation;Failure;Food Hypersensitivity;FOXP3 gene;Frequencies;Generations;genetic approach;Germ Cells;Goals;GPR15 gene;gut microbes;Health;Health Care Costs;Homing;Human;Immune response;Immune system;Immune System Diseases;Immune Tolerance;Immunosuppression;Immunotherapy;In Vitro;in vivo;Inflammatory Bowel Diseases;Inflammatory Response;Intestines;Invaded;Knowledge;Lamina Propria;Large Intestine;Ligands;Location;Mediating;Microbe;microorganism antigen;migration;Molecular;Molecular Genetics;mouse model;Mucous Membrane;novel;novel therapeutic intervention;Open Reading Frames;oral tolerance;Patients;Physiological;Play;Predisposition;Prevalence;prevent;Process;Proliferating;Public Health;receptor;Receptor Activation;Receptor Signaling;Regulatory T-Lymphocyte;Reporting;Research;Reverse Transcriptase Polymerase Chain Reaction;Role;Signal Transduction;Small intestine mucous membrane;Small Intestines;Source;Surface;T cell differentiation;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;therapeutic evaluation;Tissues;trafficking;Tretinoin;Tryptophan;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Kidney Disease;Urologic Diseases

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Kidney stones are very common, and most treatments break the stone into smaller fragments that can remain in the kidney and serve as nidi for future stone growth and symptoms recur within 5 years. The goal of this proposal is to overcome the challenges and discover the knowledge needed to develop an ultrasound device known as acoustic forceps to noninvasively target, trap, and reposition the stone from the kidney collecting system in order to facilitate their natural clearance with urine through the ureter. The development of this technology will introduce a fast noninvasive alternative that will eliminate surgical procedures, and reduce the cost associated with stone management protocols while the patient waits to relieve symptoms.

PI_NAMEs: GHANEM, MOHAMED A (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 3-Dimensional;Acoustics;Address;Affect;Algorithms;American;Applications Grants;arm;Award;Back;Bladder;career;career development;clinical implementation;Clinical Trials;Collaborations;common treatment;Complex;Control Groups;cost;Cutaneous;Data;Deposition;Devices;Educational workshop;efficacy evaluation;Elements;Emergency department visit;Event;Family suidae;Feedback;Forcep;Frequencies;Funding;Future;Geometry;Glass;Goals;Growth;Heterogeneity;Histologic;Hospitalization;Human;Image;Implant;improved;In Vitro;in vivo;indexing;industry partner;Injury;Intervention;Investigation;Kidney;Kidney Calculi;Knowledge;Laboratories;Length;Lithotripsy;Measurement;Measures;Mechanics;Mentors;Methods;Modeling;Motion;novel strategies;object shape;Operative Surgical Procedures;particle;Patients;Pelvis;Phase;Physics;Physiologic pulse;porcine model;Positioning Attribute;predictive modeling;pressure;Protocols documentation;Radiation;randomized, controlled study;Recurrence;reduce symptoms;Renal pelvis;Research;Research Personnel;Research Proposals;Residual state;responsible research conduct;Rotation;Safety;Shapes;Shock;Signal Transduction;success;Surface;symposium;Symptoms;System;Techniques;Technology;technology development;Testing;Time;tissue injury;tissue phantom;Tissues;Transducers;Translational Research;treatment arm;two-dimensional;Ultrasonic wave;Ultrasonics;ultrasound;Ureter;Ureteroscopy;Urinary tract;Urine;Urologic Diseases;Visualization

PROJECT_TITLE: Noninvasive Repositioning of Kidney Stone Fragments with Acoustic Forceps

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PHR: Memories are stored at synapses, and synapse loss is hypothesized to be an early hallmark of Alzheimer’s disease (AD). The major aims of this research are to determine if molecular mechanisms of synapse pruning mediated by an innate immune receptor expressed in neurons and its MHC class I ligands are disrupted in the presence of soluble oligomers of beta amyloid, and to link findings in mouse models of AD to human neurons and pathology by studying brain organoids derived from human iPS cells, as well as autopsy material. Because the homologous receptor in humans also binds soluble oligomers of beta amyloid, this research can offer mechanistic explanations for synapse and memory loss in human AD and may lead to new drug targets for treatment.

PI_NAMEs: SHATZ, CARLA J (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3-Dimensional;abeta oligomer;Actins;Adult;Affinity;Age Months;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Anatomy;APP-PS1;Autopsy;autosomal dominant Alzheimer's disease;Binding;Biochemistry;Brain;cell type;Cells;Cerebral cortex;Clinical Trials;cofilin;Communication;Complement;critical developmental period;Dementia;depolymerization;Deposition;Development;Disease;Drug Targeting;early onset;Electrophysiology (science);Event;experience;experimental study;Family;frontal lobe;Frontotemporal Dementia;Gene Expression;Gene Family;Genes;Genetic;Genetic study;Genetic Transcription;genome wide association study;glial activation;Goals;Health;hippocampal pyramidal neuron;Histocompatibility;HLA-A gene;Homologous Gene;Human;human induced pluripotent stem cells;Immune;Immune signaling;Immune system;Immunoglobulins;Immunohistochemistry;Immunologic Receptors;In Situ Hybridization;in vivo;induced pluripotent stem cell;Inflammation;interest;Learning;Leukocytes;Ligands;Link;Mediating;Mediator;Memory;Memory Loss;Methods;MHC Class I Genes;Molecular;mouse model;Mus;nanomolar;Nerve Block;Nervous System;neural;Neurobiology;Neurofibrillary Tangles;Neurons;neurotransmission;new therapeutic target;novel;novel therapeutics;old mice;Organoids;Outcome;Pathologic;Pathology;Pathway interactions;pharmacologic;postnatal;Process;Prosencephalon;protein aggregation;Proteins;receptor;Recombinant Proteins;Research;Resolution;RiboTag;Role;Sampling;Senile Plaques;Signal Pathway;Signal Transduction;Structure;Synapses;synaptic function;Synaptic plasticity;synaptic pruning;System;targeted treatment;tau Proteins;tau-1;Testing;Transcript;transcriptome;transcriptome sequencing;Transgenic Model;Validation;vision development;Visual System

PROJECT_TITLE: Innate immune signaling at the synapse in development and pathological Alzheimer’s disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Clinical Research;Data Science;Health Services;Hematology;Infectious Diseases;Kidney Disease;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention;Rare Diseases;Sepsis

PHR: Project Narrative The proposed project is making use of computers to analyze data from sickest patients in hospitals. We want to develop methods that work across different demographics groups and hospital settings to identify patterns in the patient data which predict who is at risk for life- threatening conditions such as Sepsis, Septic Shock, Acute Kidney Injury (AKI), Acute Respiratory Distress Syndrome (ARDS) and Respiratory Failure (RF), and who might respond to various medications which could make them better. We have a very strong team of doctors and researchers who work closely together, covering all aspects of the proposed research, which we hope will help us improve the lives of the sickest patients in the hospitals.

PI_NAMEs: NEMATI, SHAMIM  (contact)

PROGRAM_OFFICER_NAME: DENNIS, ALLISON FRANCES

PROJECT_TERMS: Accident and Emergency department;acute care;Acute Renal Failure with Renal Papillary Necrosis;Acute Respiratory Distress Syndrome;Adult;Adverse event;Algorithms;Architecture;Area Under Curve;Artificial Intelligence;authority;Biological Assay;Biometry;Blood Vessels;Caring;Case Study;Cessation of life;Clinical;cloud based;Collaborations;Computer software;Computers;Critical Illness;Data;Data Set;Death Rate;deep learning;demographics;design;Development;Devices;Effectiveness;Electronic Health Record;electronic health record system;Ensure;Environment;Evaluation;Event;Fast Healthcare Interoperability Resources;Frequencies;Funding;General Hospitals;Goals;Health;Healthcare Systems;Heterogeneity;Hospital Costs;Hospital Mortality;Hospitalization;Hospitals;Hour;Hypotension;improved;Incidence;Infection;Inflammation;Injury to Kidney;Inpatients;Institution;Intensive Care Units;interest;laboratory equipment;Learning;Life;Liver;Lung;Measurement;Measures;Medical;Metadata;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;multi-task learning;novel;organ injury;Outcome;patient population;patient response;Patients;Pattern;Performance;personalized care;Pharmaceutical Preparations;Pilot Projects;Population;portability;prediction algorithm;Predictive Analytics;predictive modeling;prevent;Prevention;Process;prognostication;prospective;Reader;Reproducibility;Research;research and development;Research Personnel;Respiratory Failure;response;Risk;Risk Estimate;Sepsis;septic patients;Septic Shock;Site;Testing;theories;Time;tool;Training;treatment response;trustworthiness;Uncertainty;Variant;ward;wearable device;Work

PROJECT_TITLE: Enhanced Metadata Design, Architecture, and Learning (MeDAL) for Development of Generalizable Deep Learning-based Predictive Analytics from Electronic Health Records

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Training the next generation of physician-scientists who will tackle the important clinical issues in Alzheimer’s disease and related dementia, frailty, and multimorbidity in aging adults requires a robust and innovative program to provide superb training on an integrated platform. We propose the Massachusetts General Hospital Diseases of Aging Pathway via Stimulating Access to Research in Residency (MGH DAP StARR) program to provide dedicated research time to residents in the Departments of Medicine and Neurology at MGH to foster longitudinal mentorship, skill development, and perform high-quality research related to fundamental questions in dementia and other age-related dysfunctions.

PI_NAMEs: HYMAN, BRADLEY T.;RITCHIE, CHRISTINE S;VYAS, JATIN M (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adult;age related;Aging;aging mechanism;aging population;aging related disease;Alzheimer's disease related dementia;apprenticeship;Area;Basic Science;Bioinformatics;Biological Markers;Biomedical Research;Boston;Cardiovascular Diseases;career;Clinical;clinical investigation;Clinical Medicine;Clinical Research;Communication;Communities;cost;Coupled;Dedications;Dementia;design;Development;diagnostic tool;Early Diagnosis;Environment;Faculty;Fellowship;Financial Hardship;Fostering;Foundations;frailty;Functional disorder;Funding;Future;Gastrointestinal Diseases;General Hospitals;General Population;Goals;Health;Hospitalists;imaging modality;implementation strategy;improved;Individual;innovation;Inpatients;Institution;Intellectual Interest;interest;Investigation;Knowledge;Laboratories;Laboratory Research;Leadership;Life;Link;Massachusetts;Measures;Medical;Medicine;Mentors;Mentorship;Metabolic Diseases;Methodology;Modeling;multidisciplinary;multiple chronic conditions;Myopathy;Neurodegenerative Disorders;Neurology;new technology;next generation;novel therapeutics;Parkinson Disease;Participant;Pathway interactions;Patient Care;Patients;Physician Assistants;Physicians;Play;Prevalence;Productivity;programs;Quality of life;Readiness;Research;Research Personnel;Research Project Grants;Residencies;Role;role model;Science;Scientist;skeletal disorder;skill acquisition;skills;Solid;Specific qualifier value;statistics;Structure;symposium;Therapeutic;Time;tool;Training;Training Programs;Translating;Translational Research;Work

PROJECT_TITLE: MGH Diseases of Aging Pathway Via Stimulating Access to Research in Residency (MGH DAP StARR)


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE An estimated 12 million US adults are living with serious illness, a condition that carries a high risk of mortality and excessively strains their caregivers. Structural racism and racial/ethnic residential segregation may affect health care for patients with serious illness by limiting access to palliative care, the specialty focused on improving quality of life for persons with serious illness and their families and limiting the capacity of family caregivers to engage with the healthcare system. We will conduct at population-based, multi-level, mixed- methods study within and across the state of Massachusetts to disentangle the relationships between residential segregation, neighborhood deprivation, and healthcare utilization in serious illness in order provide evidence that racism, not patient mistrust, is a primary barrier to equitable palliative care and health outcomes.

PI_NAMEs: DESANTO-MADEYA, SUSAN ;TJIA, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Action Research;Address;Adult;advanced dementia;Affect;American;arm;care coordination;care delivery;Caregiver support;Caregivers;Caring;Case Study;Cessation of life;Chronic Obstructive Pulmonary Disease;Communities;community engagement;community partners;Community Surveys;Complex;daily functioning;Data;Databases;Decision Making;deprivation;design;Education;Employment;End stage renal failure;Equity;Ethnic Origin;Ethnography;Exhibits;Family;Family Caregiver;Fostering;Health;health care service utilization;health disparity;health equity;Health Services Accessibility;Healthcare;Healthcare Systems;Heart failure;high risk;Hospitalization;Hospitals;Housing;improved;Individual;informant;Institution;Institutional Racism;Interview;Investigation;Length of Stay;Link;Malignant Neoplasms;Massachusetts;Measures;Mediating;Mediation;Medical;medical schools;medical specialties;Medicine;Methods;mortality risk;multidisciplinary;Neighborhoods;older adult;Outcome;Palliative Care;Patient advocacy;Patient Care;Patient-Focused Outcomes;people of color;Persons;Policies;Policy Analysis;Population;population based;Prevalence;Quality of life;Race;racial discrimination;racism;Recommendation;residential segregation;Resource-limited setting;Resources;Rhode Island;Sampling;School Nursing;segregation;Services;social;Societies;Structural Racism;Structure;System;Time;Travel;United States National Institutes of Health;Universities;Variant;Woman

PROJECT_TITLE: Structural Racism and Engagement of Family Caregivers in Serious Illness Care


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

PHR: PROJECT NARRATIVE In post-traumatic stress disorder (PTSD), intrusive, traumatic, autobiographical memories lead to anxiety symptoms, and recent work suggests a novel repetitive pulse transcranial magnetic stimulation (rTMS) brain target that might bring relief. Since this proposed target is not well understood, our goal is to use functional magnetic resonance imaging (fMRI) to identify the brain regions and networks that change with rTMS stimulation at this target in PTSD patients. This project will help us understand how rTMS stimulation at the proposed target affects the brain, and will reveal the benefits of a personalized targeting.

PI_NAMEs: ROSEN, ALLYSON C (contact)

PROGRAM_OFFICER_NAME: TUMA, FARRIS KEITH

PROJECT_TERMS: Affect;Amygdaloid structure;Anatomy;Anterior;Anxiety;anxiety symptoms;anxiety treatment;Area;Atlases;Autobiography;blood oxygenation level dependent response;Brain;Brain region;Clinical;Clinical Trials;Cognition;connectome;cranium;Data;Detection;Disease;emotion regulation;Emotional;Evaluation;executive function;follow-up;Fright;frontal lobe;Functional Magnetic Resonance Imaging;Goals;Human;improved;Inferior;Insula of Reil;interest;Laboratories;Lead;Learning;Left;Measures;Mediating;Memory;Mental Depression;Moods;neuroregulation;novel;Parietal Lobe;Patients;Persons;Physiologic pulse;Post-Traumatic Stress Disorders;Prefrontal Cortex;Process;Protocols documentation;Reporting;Resistance;response;Rest;Scalp structure;secondary analysis;support network;symptomatic improvement;Symptoms;System;Techniques;Testing;Transcranial magnetic stimulation;treatment response;Veterans;virtual;Work

PROJECT_TITLE: Targeting the Default Mode Network: A TMS-fMRI Study

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences;Schizophrenia

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Our studies focus on the molecular basis of memory consolidation and the particular role of a gene termed Arc. We have discovered a new signaling pathway mediated by Arc that appears important for memory and for understanding schizophrenia. Studies will reveal the molecular basis of Arc signaling, its contribution to normal memory, and the impact of its dysfunction in relation to schizophrenia.

PI_NAMEs: WORLEY, PAUL F (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Adult;Animals;antagonist;Behavior;Behavioral;Binding;Biological Assay;Biological Markers;Brain;brain tissue;Chemosensitization;Collaborations;Complex;complex DRIP-ARC protein;Data;Databases;Development;Developmental Biology;Disease;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;endophenotype;Endosomes;excitatory neuron;Excitatory Synapse;experimental study;Failure;Functional disorder;Gene Expression Profile;gene function;Genes;Genetic Load;Genetic Transcription;Goals;hippocampal pyramidal neuron;Human;human disease;Human Genetics;human subject;Immediate-Early Genes;in vivo;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Interneurons;Interruption;Knockout Mice;Learning;Link;Long-Term Depression;Mass Spectrum Analysis;Mediating;Membrane;Memory;memory consolidation;Mental Health;Metabolic;Modeling;Molecular;molecular assembly/self assembly;Monitor;mouse model;Mus;Mutant Strains Mice;N-Methyl-D-Aspartate Receptors;Neurons;neurotransmission;novel;Parvalbumins;Pathway interactions;Pharmacology;phosphoproteomics;Phosphorylation;Physiological;PIK3CG gene;Process;Proteins;Proto-Oncogene Proteins c-akt;Receptor Signaling;recruit;Reporter;Risk;Role;Schizophrenia;Signal Pathway;Signal Transduction;Slice;Specificity;Stress;Structure;Synapses;Synaptic plasticity;Testing;trafficking;transcriptome sequencing;Translating;Travel;Vertebral column

PROJECT_TITLE: Arc and synaptic plasticity


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Epilepsy;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: EUGENE

ORG_NAME: BRAIN ELECTROPHYSIOLOGY LABORATORY COMPANY, LLC

ORG_STATE: OR

PHR: Relevance to Public Health In the US, the lifetime cost of epilepsy for an estimated 181,000 people with an onset in 1995 is projected at $11.1B and the annual cost for an estimated 2.3 million prevalent cases is estimated at $12.5B. In many of these cases, the treatment procedure requires identifying the abnormal brain region involved and removing it via neurosurgery. Epilepsy surgery costs over $100,000 per case and since the surgery is complex and often involves two phases, image analysis software is critical to integrate multimodal imaging and EEG recording for pre- and intra-operative decision support. In this proposal, we aim to build such a product.

PI_NAMEs: LUU, PHAN  (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Accounting;Achievement;Anatomy;bioimaging;Brain;brain abnormalities;Brain region;brain tissue;candidate identification;Certification;Clinical;Cognitive;Complex;Computer software;cost;cost estimate;cranium;Data;data integration;data resource;Databases;design;Development;Digital Imaging and Communications in Medicine;electrical source imaging;Electrodes;Electroencephalography;Ensure;Environment;Epilepsy;Evaluation;Excision;experience;Failure;Foundations;Functional Magnetic Resonance Imaging;Goals;Guidelines;Head;Hospitals;Image;Image Analysis;image guided;imaging modality;Implant;implantation;improved;Individual;innovation;Intuition;Life;life time cost;Magnetic Resonance Imaging;Maps;Measures;Methods;Modality;Modeling;Monitor;Movement;Multimodal Imaging;multimodal neuroimaging;multimodality;Neuronavigation;Neuropsychology;Neurosurgeon;neurosurgery;Online Systems;Operative Surgical Procedures;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Physicians;Positioning Attribute;Positron-Emission Tomography;Postoperative Period;Preparation;Procedures;product development;Public Health;Qualifying;Regulation;Research;Resistance;Resolution;Secure;Seizures;single photon emission computed tomography;Site;Small Business Innovation Research Grant;Source;source localization;Structure;success;Symptoms;System;Technology;technology platform;Testing;Tissues;tool;treatment response;usability;Validation;web interface;Work;X-Ray Computed Tomography

PROJECT_TITLE: Sourcerer IC: A Web-Based Integrative Multi-Modal Workflow for Epilepsy Surgical Planning


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Pain Research;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE The Mas-related G protein coupled receptors (MRGs) represent, in humans, a 10-member family of receptors that are involved in sensing nociceptive stimuli such as pain and itch. MRG-family receptors are also important for the actions and side-effects of several drugs of abuse. Here we will solve the structures of representative MRG-family receptors and leverage this information to understand their signaling and to develop selective chemical probes to modulate their function, with potential utility as therapeutic leads.

PI_NAMEs: ROTH, BRYAN L. (contact);SHOICHET, BRIAN K

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Acceleration;addiction;Adrenergic Receptor;Adult;Afferent Neurons;Affinity;African ancestry;Agonist;antagonist;antinociception;Biochemical;Biological;Bioluminescence;Chemicals;chronic pain;chronic pain management;Cigarette;Communities;Complex;Constipation;Coupling;Cryoelectron Microscopy;Disease;Docking;Dopamine;Drug Interactions;drug of abuse;Drug Prescriptions;Family;Family member;Functional disorder;G-Protein-Coupled Receptors;Genetic Polymorphism;GTP-Binding Proteins;Human;Hypersensitivity;Individual;Investigation;Libraries;Ligands;Link;mast cell;Mediating;Melatonin;meter;Molecular;Molecular Target;Mutagenesis;neural circuit;Nociception;Nociceptive Stimulus;non-opioid analgesic;Opioid;Opioid Receptor;Overdose;Pain;pain relief;Peptides;Pharmaceutical Preparations;Population;preference;prescription opioid;Primates;Pruritus;receptor;Reporting;Resources;response;Risk;Sensory Ganglia;side effect;Signal Transduction;Site-Directed Mutagenesis;small molecule;Stimulus;Structure;Testing;Therapeutic;therapeutic target;tool;virtual library

PROJECT_TITLE: STRUCTURE AND FUNCTION OF MRG-FAMILY RECEPTORS

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative By studying healthcare organizations, the nurses providing care in them, and the patients experiencing that care over time, we aim to understand the causal nature of effects that investments in nursing have on patient outcomes and health disparities. In doing so, we gain crucial information regarding where organizational reform is needed, and how best to design and target policy interventions and organizational innovations that can transform the care environment to maximize safe, effective, and equitable care for patients.

PI_NAMEs: MCHUGH, MATTHEW D. (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Academy;Adherence;Age;Attention;authority;Back;burnout;care costs;care delivery;Care given by nurses;care outcomes;Caring;Clinical;clinical care;Clinical Nursing;Clinical Protocols;Clinical Trials;Community Healthcare;Complex;cost;COVID-19;COVID-19 pandemic;Data;Data Collection;Data Set;Decision Making;demographics;design;Discipline of Nursing;Disparity;Education;Electronics;Ensure;Environment;Equity;ethnic disparity;ethnic health disparity;ethnic minority;Ethnic Origin;Evaluation;Event;evidence base;experience;Fostering;Frail Elderly;Funding;Health;health care service organization;health disparity;health equity;Healthcare;Hospitals;improved;improved outcome;innovation;interest;Intervention;Investments;Knowledge;Link;longitudinal analysis;longitudinal design;Measurement;Measures;Medicine;Methods;Minority;minority patient;multiple chronic conditions;Nature;Nurse's Role;Nurses;Nursing Education;Nursing Homes;Nursing Staff;Organizational Change;Organizational Innovation;Outcome;outcome disparities;Ownership;Pathway interactions;Patient Care;patient population;Patient-Focused Outcomes;Patients;Personal Satisfaction;Play;Policies;Policy Making;Population;primary care practice;professional atmosphere;programs;Protocols documentation;Quality of Care;Race;racial disparity;racial health disparity;racial minority;Recommendation;Research;Resources;response;Risk Factors;safety net;Sampling;Sepsis;Surveys;Time;Translating;trend;Trust;Work

PROJECT_TITLE: Multilevel Panel Study of Effects of Changes in Nursing on Health Equity and Patient Outcomes

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: ROCHESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE The essential spliceosome protein SF3B1 functions as a hub to coordinate the positioning and dynamic rearrangements of numerous RNA and protein splicing factors. SF3B1, as well as many of its interacting cofactors, are frequently mutated, amplified, or deleted in cancers and in developmental syndromes, yet rather than affecting all introns equally, these disease-associated alterations in the core of the spliceosome have different and specific effects on subsets of introns. Understanding the intronic codes that confer sensitivity to these naturally occurring genetic changes will provide insight into the mechanisms of spliceosome function as well as the biological pathways distorted by spliceosome dysfunction that may present new therapeutic vulnerabilities.

PI_NAMEs: BOUTZ, PAUL LAWRENCE (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 3' Splice Site;Affect;Alleles;Amino Acids;Auxins;Binding;Biological;Biology;Catalysis;causal variant;Cell Line;cell type;Cells;Classification;Code;cofactor;Copy Number Polymorphism;CRISPR-mediated transcriptional activation;Data;deep learning;deep neural network;Deletion Mutation;Dependence;Development;Disease;Epitopes;Etiology;Event;Exhibits;Exons;experimental study;Functional disorder;Gene Amplification;Gene Expression;gene expression variation;Gene Mutation;Genes;Genetic;Genetic Diseases;Genetic Screening;Genetic Transcription;genome-wide;genomic data;Genomics;Germ Lines;helicase;Heterozygote;Human;human disease;Individual;insight;Introns;Machine Learning;Malignant Neoplasms;Mechanics;Mediating;Methods;Missense Mutation;Modeling;Motor;mutant;Mutate;Mutation;Normal Cell;novel;novel therapeutics;Outcome;patched protein;Pathway interactions;Pattern;Phenocopy;Positioning Attribute;Procedures;Protein Splicing;Proteins;recombinase;recombinase-mediated cassette exchange;recruit;response;RNA Binding;RNA Helicase;RNA Splicing;Role;Series;Site;Specificity;Spliced Genes;Spliceosomes;Structure;Syndrome;System;Techniques;Testing;tool;transcriptome;transcriptome sequencing;tumor;Variant;virtual

PROJECT_TITLE: Genomics-based approaches to understanding mechanistic alterations of spliceosome function in disease states

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative The human genome sequence was originally thought to be a user manual for understanding and curing human diseases, but translating its contents into the testable experiments required to discover new medicines is tedious, expensive, and sometimes impossible for certain “undruggable” genes. My laboratory is developing distributable technology that will democratize this process, and further render it “plug-and-play” to target any disease-related gene encoded in the genome. This new therapeutic strategy is likely to have broad applicability to the discovery of new antibiotics, antivirals, anti-cancer agents, and cholesterol-lowering drugs to name a few.

PI_NAMEs: PAEGEL, BRIAN M (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Anti-viral Agents;Antibiotics;Antineoplastic Agents;Binding;Biological Assay;Bypass;CCR5 gene;Cell Culture Techniques;Cells;Cellular Assay;cellular engineering;Chemicals;Cholesterol;clinically relevant;Collection;Data Set;Democracy;design;Disease;DNA;drug discovery;Drug Targeting;Engineering;Ensure;experimental study;Funding;Genes;Genome;high throughput screening;HIV;Human;human disease;Human Genome;Human Genome Project;hypercholesterolemia;In Vitro;instrumentation;Investments;Laboratories;Libraries;Manuals;Medicine;Methods;Microfluidics;Modality;Names;new therapeutic target;novel;novel therapeutic intervention;Peptide Signal Sequences;Pharmaceutical Preparations;Phase;Play;Polymers;Process;programs;Protein Biosynthesis;protein expression;Protein Synthesis Inhibition;Proteins;Proteome;ribosome profiling;Ribosomes;scale up;screening;Site;small molecule;Solid;Source;Structure;Surface;synthetic biology;System;Technology;technology development;tissue culture;Translating;translation assay;Translations;Vision

PROJECT_TITLE: Activity-Based DNA-Encoded Library Technology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative (Overall) This is a program project grant that is centered on improving our understanding of how immune dysregulation can arise and lead to autoimmunity and inflammation. The results of the projects here will help improve our ability to both detect and devise logical treatment strategies for autoimmunity and immune dysregulation.

PI_NAMEs: ANDERSON, MARK S (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Animal Model;Autoantibodies;Autoimmune Diabetes;Autoimmunity;Cells;central tolerance;Childhood;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;CRISPR/Cas technology;Critical Pathways;Defect;Diagnosis;Disease;Epistatic Gene;Functional disorder;gain of function;gene interaction;Genetic Engineering;Genetic Models;genetic variant;genome editing;Grant;Health;Heterozygote;Human;Human Genetics;Immune;Immune system;Immune System Diseases;Immune Tolerance;immunodeficiency;improved;Inflammation;Insulin-Dependent Diabetes Mellitus;Maps;Mediating;Methods;Modeling;mouse model;Mus;Mutation;novel;Outcome;Pathogenesis;Patients;peripheral tolerance;Personal Satisfaction;Phage ImmunoPrecipitation Sequencing;Population;Process;Program Research Project Grants;programs;repaired;Resources;response;Sampling;Signal Transduction;Skin;STAT3 gain of function;STAT3 gene;Syndrome;synergism;T-Lymphocyte;therapy development;treatment strategy;Variant;Work

PROJECT_TITLE: STAT3 variants as a rheostat of immune tolerance


NIH_SPENDING_CATS: Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE This project will develop novel methods based on unsupervised machine learning to derive embeddings for medical concepts and patient clinical histories that combine heterogeneous multi-modal healthcare data. These methods will generate novel data representations that can benefit clinical predictive analyses as well as medical research and discovery. We will build a publicly-available framework to share and combine embeddings via federated learning which will lead to representations that also capture diverse populations and promise to reduce several biases of machine learning models in healthcare.

PI_NAMEs: CAMPANELLA, GABRIELE  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Address;biobank;Case/Control Studies;Catalogs;Clinical;clinical imaging;clinical predictors;cohort;Communities;Complex;Computer Vision Systems;Data;data modalities;Data Reporting;Data Set;Data Sources;deep learning;Development;Dimensions;Disease;disease phenotype;disorder subtype;Effectiveness;Electrocardiogram;Electronic Health Record;feature selection;federated learning;Genetic;genome wide association study;Health system;Healthcare;Healthcare Systems;Heterogeneity;high dimensionality;Hospitals;Image;improved;Institution;Intuition;Joints;Knowledge;Label;Learning;Link;Literature;Machine Learning;machine learning model;Manuals;Masks;Medical;Medical Research;Medicine;Methods;Modality;Molecular;multimodal data;multimodality;Natural Language Processing;New York;next generation;novel;Onset of illness;operation;Outcome;patient stratification;Patients;Pattern;personalized health care;personalized medicine;personalized predictions;Phenotype;Population;Population Heterogeneity;Process;public repository;PubMed;Recording of previous events;Records;repository;Research;Research Personnel;Secure;Specific qualifier value;success;Supervision;System;Techniques;Testing;Text;tool;Typology;Unified Medical Language System;unsupervised learning;vector;Visualization;Work

PROJECT_TITLE: Multi-modal unsupervised embeddings to advance machine learning in healthcare


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Mandibular anomalies are common birth defects that require comprehensive, sometimes repetitive corrective surgeries to manage individual cases, often placing a heavy financial and emotional burden on patients and their families. Development of therapeutic efforts requires a thorough understanding of mandibular development and the timing of events in dysmorphogenesis. We offer innovative approaches for determining the molecular, cellular, and developmental bases of morphogenesis of the mandible and its cartilaginous precursor, Meckel’s cartilage, in normal individuals and in craniofacial conditions with a small mandible.

PI_NAMEs: JABS, ETHYLIN WANG;KAWASAKI, KAZUHIKO ;PERRINE, SUSAN MARIE (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: 3-Dimensional;Acids;Affect;airway obstruction;Anatomy;Anterior;Area;Atlases;Automobile Driving;base;Behavior;biological research;bone;bone repair;C57BL/6 Mouse;Cartilage;cartilage cell;cartilage development;cartilaginous;Cell Lineage;Cell Proliferation;Cells;Chondrocytes;Complex;Congenital Abnormality;Coupled;craniofacial;Data;Defect;Dermal;design;Development;Disease;Embryo;Embryonic Development;Emotional;Event;Evolution;experimental study;Family;feeding;First Pharyngeal Arch;Genes;Growth;Histologic;Human;Hypertrophy;Image;Incus;Individual;innovation;Investigation;Jaw;Knowledge;Length;Ligaments;Link;Location;LoxP-flanked allele;Malleus;Mammals;Mandible;Mandibular Diseases;Meckel's cartilage;Methods;microCT;Micrognathism;middle ear;migration;mineralization;Modeling;Modernization;Molecular;Morphogenesis;Mus;mutant;Natural regeneration;Neural Crest Cell;Newborn Infant;novel;novel strategies;Operative Surgical Procedures;Pathway Analysis;Patients;Pharyngeal structure;Phenotype;Phylogenetic Analysis;Physiologic Ossification;Population;Positioning Attribute;Prevention;Process;Quality of life;Reporter;Research;Respiration;Rod;Role;Sampling;scaffold;Shapes;Skeleton;Source;spatiotemporal;Speech;Stains;Structure;success;Syndrome;Tamoxifen;therapeutic development;Three-Dimensional Imaging;Time;Tissue-Specific Gene Expression;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Tubular formation;Variant;Vertebrates

PROJECT_TITLE: Cartilage and bone of the lower jaw in development and disease

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Cardiovascular;Complementary and Integrative Health;Diabetes;Dietary Supplements;Genetics;Heart Disease;Human Genome;Maternal Health;Nutrition;Obesity;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: SIOUX FALLS

ORG_NAME: SANFORD RESEARCH/USD

ORG_STATE: SD

PHR: Fetal overnutrition due to maternal diabetes or obesity increases the risk of newborn and adult heart disease in the developing baby, and even more, this risk can be passed on to the next generation. Our previous and preliminary work indicates that damaged mitochondria and their byproduct, reactive oxygen species (ROS) play a causative role. This project will determine 1) whether ROS damages DNA to trigger the problem for not only one, but several generations, and 2) if limiting dietary fat during pregnancy or 3) taking antioxidants during family planning can mitigate the risk.

PI_NAMEs: BAACK, MICHELLE LEIGH (contact)

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: Address;Adult;Aging;Antioxidants;Birth;blastocyst;Breeding;Calories;Cardiac;Cardiac health;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder risk;Cell Death;clinical application;clinical effect;clinical practice;clinically relevant;Coenzyme Q10;Counseling;Deoxyguanosine;Development;Diabetes Mellitus;diabetic;Diabetic mother;Diet Modification;dietary;dietary antioxidant;Dietary Fats;Dietary Intervention;Dietary Supplementation;Disease;DNA Damage;DNA Repair;effective intervention;efficacy testing;Family;Family Planning;Fatty acid glycerol esters;Fatty Acids;Female;Fertilization;fetal;Fetus;Generations;genome-wide;Genomic approach;Genomic Instability;genomic profiles;Genomics;Germ Lines;Gestational Diabetes;glycemic control;Goals;Heart;heart disease risk;Heart Diseases;heart function;High Fat Diet;high risk;High Risk Woman;Human;Hyperglycemia;Hyperlipidemia;Impairment;implantation;improved;Inflammation;Inheritance Patterns;Inherited;innovation;Intake;Intervention;Lesion;Life;Link;maternal diabetes;maternal obesity;Mediating;Metabolic Diseases;Metabolic stress;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;mortality;mother nutrition;Mothers;Mutation;Myocardial dysfunction;Newborn Infant;next generation;Obesity;offspring;Outcome;Ovary;Overnutrition;Ovulation;oxidative damage;oxidative DNA damage;Oxidative Stress;Pattern;Phenotype;Play;Population;Predisposition;Pregnancy;Pregnancy Trimesters;prevent;Prevention;programs;Rattus;Reactive Oxygen Species;Risk;risk mitigation;Role;screening;Shapes;Supplementation;Testing;Third Pregnancy Trimester;Time;transcriptome;transcriptomics;Ubiquinone;whole genome;Work

PROJECT_TITLE: Dietary interventions to modulate heart health in offspring born to diabetic mothers and the subsequent generation.

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Lymphatic Research;Regenerative Medicine

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: NARRATIVE Heart failure is still the major cause of death worldwide, with a pressing need for new therapeutic approaches. Recent studies reported that stimulation of lymphatic growth improve heart function in ischemic heart disease, however, the mechanisms have not been fully understood. In this proposal, we will take advantage of variety lymphatic loss- and gain- of function mouse strains to characterize in details the lymphatic functions during heart injury progression, and determine the underlying mechanism by which lymphatic vasculature improve cardiac repair.

PI_NAMEs: LIU, XIAOLEI  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Address;Animal Model;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Attenuated;Biology;Cardiac;Cardiac Myocytes;cardiac repair;cardioprotection;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cell Death Induction;coronary fibrosis;Data;Development;Disease;Engraftment;gain of function;Genes;Goals;Growth;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;heart preservation;Human;immune cell infiltrate;immune clearance;immune function;Immune response;Impairment;improved;Inflammatory Response;Injury;Ischemia;Knowledge;Lead;Liquid substance;loss of function;Lymphangiogenesis;Lymphatic;lymphatic drainage;Lymphatic Endothelial Cells;Lymphatic function;lymphatic vasculature;Mediating;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;Myocardial Infarction;Myocardial Ischemia;Myocarditis;novel;novel therapeutic intervention;Paracrine Communication;Pathway interactions;Publishing;Recombinant Proteins;Regulation;repaired;Reporting;Research;Role;Route;Signal Transduction;Therapeutic;Time;transcriptome sequencing;VEGFC gene;Work

PROJECT_TITLE: Dissecting the functional roles of cardiac lymphatics in ischemic heart disease

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_NAME: TRINITY UNIVERSITY

PHR: PROJECT NARRATIVE Marmosets, squirrel monkeys, and owl monkeys are small South American monkeys used in reproduction, metabolism, infectious disease, aging and neuroscience studies. Identification of biomarkers of inflammation and metabolic hormones is critical for validation of animal models in biomedical research; however, available immunological reagents for biomarkers from these New World Monkeys are scarce. This application proposes to fill this void by generating recombinant NWM proteins, producing mouse monoclonal antibodies against them, validating immunological assays using these reagents, and distributing reagents and related scientific information to interested investigators.

PI_NAMEs: GIAVEDONI, LUIS DAVID (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: adiponectin;age related neurodegeneration;Aging;Aliquot;Amino Acids;Animal Model;Animals;Antibodies;Aotus primate;Area;assay development;Behavior;Binding;Biological;Biological Assay;Biological Markers;biomarker identification;Biomedical Research;Biotechnology;Breeding;C-reactive protein;Callithrix;Callithrix jacchus jacchus;Cebidae;Cells;Cercopithecidae;Chronic Disease;Clinical;Clinical Trials;Cognition;Communicable Diseases;cross reactivity;CXCL10 gene;CXCR3 gene;cytokine;Data;Development;enzyme linked immunospot assay;Enzyme-Linked Immunosorbent Assay;Epitope Mapping;Epitopes;Eukaryotic Cell;Exposure to;Gastrointestinal Hormones;Generations;Genes;genetic manipulation;Goals;Granzyme;Haplorhini;Health;Homologous Gene;Hormones;Human;human disease;human model;Immunologic Techniques;Immunologics;Immunology procedure;improved;Infection;Inflammation;Inflammatory;Institution;Insulin;interest;Interferon Type II;Interleukin-10;Interleukin-4;Interleukin-6;Intervention;Leptin;life span;Longitudinal Studies;Macaca;Macaca mulatta;Malaria;Membrane Glycoproteins;Metabolic;Metabolic hormone;Metabolic syndrome;Metabolism;Modeling;Monkeys;Monoclonal Antibodies;Multiple Sclerosis;murine monoclonal antibody;Mus;National Institute of Allergy and Infectious Disease;National Institute of Mental Health;Neurodegenerative Disorders;Neurology;Neurosciences;Night Monkey;nonhuman primate;Obesity;Outcome;Pathology;Plasma;Pre-Clinical Model;preclinical study;Primates;Process;Production;Proteins;Protocols documentation;R24;Reagent;Recombinant Proteins;Recombinants;Recommendation;Reporting;Reproduction;Research;Research Personnel;Resources;Rodent;Saimiri;Sampling;Science;Scientist;Social Behavior;South America;South American;Specificity;Stains;Techniques;Technology;Testing;tool;Transfection;Transgenic Organisms;United States;United States National Academy of Sciences;United States National Institutes of Health;Validation;validation studies;Vision;web site;Western Blotting

PROJECT_TITLE: Development of Immunological Reagents for the Identification of New World Monkey Biomarkers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-A(55)R]


ADMINISTERING_IC: EY

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE The mammalian retina is comprised of hundreds of distinct neuronal subtypes that are precisely assembled into functional circuits. This project examines how selectively expressed transcription factors are involved in the specification and morphological maturation of specific neuronal subtypes in the retina during development. These studies will provide important insight that can be used to guide regenerative therapies in the nervous system following injury or disease.

PI_NAMEs: WRIGHT, KEVIN  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Adopted;Affect;Amacrine Cells;ATAC-seq;Axon;Biological Models;Cell Surface Receptors;Cells;cellular imaging;Cellular Morphology;Chromatin;Complex;Data;Defect;Development;Disease;Electrophysiology (science);Endowment;experimental study;gain of function;gene regulatory network;Genes;Genetic;Genetic Transcription;Genomic approach;Goals;homeodomain;Individual;inhibitory neuron;Injury;Inner Plexiform Layer;insight;loss of function;Molecular;Morphology;Nervous System;neural circuit;Neurons;novel;Pathway interactions;Pattern;Peptide Initiation Factors;Population;Preparation;Process;programs;Property;public health relevance;receptor;regenerative therapy;Regulator Genes;Retina;retinal neuron;Role;selective expression;Shapes;Signal Transduction;single cell sequencing;Specific qualifier value;starburst amacrine cell;Stereotyping;Stratification;Testing;transcription factor;Transcriptional Regulation;transcriptome sequencing;virtual;Visual

PROJECT_TITLE: Transcriptional control of retinal neuron specification and maturation.

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cerebrovascular;Machine Learning and Artificial Intelligence;Neurosciences

PHR: PROJECT NARRATIVE This project will develop advanced analyses that combine time-resolved phase-contrast MRI (4D flow MRI) and computational fluid dynamics to provide increased 4D flow resolution. In this research program, we aim to generate super-resolution velocity maps - maps higher resolution than the acquired 4D flow MRI for improved quantification of cerebral hemodynamics. This will better identify, on a patient-specific basis, hemodynamic descriptors that can be used to guide patients to urgent surgical intervention and differentiate them from others where watchful waiting is preferred.

PI_NAMEs: WANG, YAN  (contact)

PROGRAM_OFFICER_NAME: FARAHANI, KEYVAN

PROJECT_TERMS: 3-Dimensional;4D MRI;Address;automated analysis;automated segmentation;Blood Vessels;Caliber;Cardiac;cerebral hemodynamics;Cerebrum;Clinical;Complex;Computational Geometry;Computer Models;contrast enhanced;Data;Data Set;Decision Making;deep learning;Descriptor;Development;Diastole;Disease Progression;Evaluation;Evolution;Experimental Models;Funding;Generations;Geometry;Growth;hemodynamics;human data;Image;improved;in vivo;Intervention;Intracranial Aneurysm;intracranial artery;Learning;learning network;Liquid substance;Magnetic Resonance Imaging;Manuals;Maps;Measures;Medical;Methods;Mission;Modeling;Motion;National Heart, Lung, and Blood Institute;neural network;Noise;novel;Operative Surgical Procedures;Patient observation;Patient-Focused Outcomes;Patients;Phase;predict clinical outcome;predictive marker;Process;programs;Pulsatile Tinnitus;Reference Standards;Research;Resolution;Rupture;Sampling;secondary analysis;simulation;Structure;System;Systole;Technology;Time;tool;Training;treatment response;ultra high resolution;Vascular Diseases;Veins;Venous;virtual

PROJECT_TITLE: A computational approach combining 4D Flow and CFD for improved determination of cerebral hemodynamics

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: Narrative The long-term goal of my research program is to develop methods and tools for comparative analysis of molecular sequences. In this project, we will develop a new class of phylogenomic methods based on sparse machine learning and benchmark their absolute and relative performance. New techniques and their software implementation will greatly facilitate data analyses that are vital for evolutionary and functional genomics.

PI_NAMEs: KUMAR, SUDHIR  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Benchmarking;Big Data Methods;Biological;Categories;comparative;Complement;Computer software;Data Analyses;Data Set;Democracy;Development;functional genomics;Genes;genomic locus;Genomic Segment;Genomics;Goals;graphical user interface;improved;innovation;interest;large scale data;Libraries;Life;Machine Learning;Memory;Methods;model building;Modeling;Molecular Analysis;Molecular Evolution;Nucleotides;Pattern;Performance;Phylogenetic Analysis;programs;Proteins;Reproducibility;Research;Signal Transduction;Techniques;Time;tool;trait;Trees

PROJECT_TITLE: Methods for Evolutionary Genomics Analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Sleep Research

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE The relationship between sleep and epilepsy can provide key insights into how network dynamics influence epileptic activity; however, the mechanisms that underly this relationship are largely unknown. In this proposal, I will investigate this interplay by 1) probing physiologic sleep-wake states that are naturally associated with different epileptic potential in patients with epilepsy and 2) elucidating pathologic, state-dependent network features that are predictive of epileptic activity. This investigation will take steps toward a long-term goal of devising rational strategies for neuromodulation-based therapies that reconfigure the epileptogenic network toward having favorable dynamics with low epileptogenic potential in patients with drug-resistant epilepsy.

PI_NAMEs: FAN, JOLINE  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Address;Anatomy;anti-epileptic agents;Area;Award;Biometry;biophysical model;Biophysics;Brain;Brain region;career;career development;Chronic;Clinical;Clinical Trials;connectome;Coupling;Data;Development Plans;Diffusion Magnetic Resonance Imaging;Drug resistance;Electrophysiology (science);Epilepsy;epileptiform;Frequencies;frontal lobe;Goals;Human;Image;improved;innovation;insight;Intractable Epilepsy;Investigation;Knowledge;Light;Location;Machine Learning;Magnetoencephalography;Measures;Medical;Mentorship;Methods;Modeling;multidisciplinary;multimodality;neural;neural patterning;neuroregulation;non rapid eye movement;Outcome;Partial Epilepsies;Pathologic;Pathway Analysis;Patients;Persons;Pharmaceutical Preparations;Physicians;Physiological;Play;predictive modeling;programs;Property;Quality of life;rational design;Research;Research Project Grants;Scientist;Seizures;signal processing;skills;Sleep;Structure;Therapeutic;therapy design;Time;tool;tractography;Training;Translational Research;treatment effect;Variant;Wakefulness;Work

PROJECT_TITLE: Network dynamics of sleep-wake states in epilepsy

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ORG_CITY: FORT WORTH

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

PHR: Sleep apnea (SA) affects 15-25% of the US population and is associated with increased risk for cardiovascular disease. Most patients are diagnosed with SA after it is well established. This animal model provides us with a unique opportunity to determine the mechanisms underlying the pathogenesis of this disorder with the hope of identifying new biomarkers and treatment modalities for SA and cardiovascular disease.

PI_NAMEs: FARMER, GEORGE EDWARD (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Affect;Angiotensin II;Angiotensin Type 1a Receptor;Angiotensins;Animal Model;awake;biomarker identification;Blood Pressure;Brain;Brain-Derived Neurotrophic Factor;carbon fiber;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cells;chloride-cotransporter potassium;Chlorides;Chronic;Data;Diagnosis;Disease;Electrodes;Electrophysiology (science);experimental study;gamma-Aminobutyric Acid;Gene Expression;Genetic Transcription;Goals;Hypertension;Hypoxemia;Hypoxia;Image;In Vitro;in vivo;Lamina Terminalis;Lesion;Maps;Mediating;Modality;Modeling;Nerve;Neurons;Nitric Oxide;Nitric Oxide Synthase;Nitric Oxide Synthase Type I;novel;optogenetics;paraventricular nucleus;patch clamp;Pathogenesis;Patients;Peripheral;Physiological;Population;preoptic nucleus;Pressoreceptors;pressure;presynaptic;prevent;programs;Radio;Rattus;Renin-Angiotensin System;Research;Rhodopsin;Role;Signal Transduction;Sleep Apnea Syndromes;Slice;Sodium-Potassium-Chloride Symporters;Subfornical Organ;Synapses;synaptic function;System;Telemetry;temporal measurement;Testing

PROJECT_TITLE: Intermittent hypoxia and hypertension: Role of the lamina terminalis

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Climate-Related Exposures and Conditions;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Primary Health Care;Social Determinants of Health

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Project Narrative Providers and policymakers in Puerto Rico are seeking to dramatically expand investments in primary care as part of their recovery from Hurricane Maria, but the ability of Puerto Rico’s physician organizations to undertake large-scale primary care transformation remains unclear. The proposed study will measure changes in physician supply, access, quality of care, and care coordination before and after Hurricane Maria in four types of physician organizations (federally qualified health centers, small independent medical groups, large independent medical groups, and vertically integrated medical groups) to identify high and low-performing physician organizations. We will conduct interviews with leaders of these organizations to identify the advanced primary care infrastructure they have sought to implement as well as implementation barriers, and we will interview Medicare beneficiaries living with Alzheimer’s disease (or Alzheimer’s disease related dementias) and their caregivers to better understand their unmet care needs and how these needs differ across the four types of physician organizations.

PI_NAMEs: TIMBIE, JUSTIN W. (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Advisory Committees;Alternative Health;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Area;beneficiary;care coordination;care delivery;Caregivers;Caring;Cessation of life;Clinic;Collaborations;college;Complex;Contracts;Data;design;Disasters;dual eligible;Economics;Eligibility Determination;Enrollment;experience;falls;Federal Government;Federally Qualified Health Center;Fee-for-Service Plans;Financial Support;food shortage;Funding;Future;Geography;health care delivery;health care service;health care service organization;health disparity;health disparity populations;Health Personnel;health plan;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Hispanic Americans;Hospitals;Hurricane;implementation barriers;improved;Incentives;informal caregiver;Infrastructure;interest;Interview;Investments;Long-Term Care;Long-Term Effects;Low income;Managed Care;Measures;Medicaid;Medical;medical specialties;Medicare;Methods;migration;Modeling;older adult;older patient;Organizational Models;Outcome;patient advocacy group;payment;Performance;Persons;Physicians;Policy Maker;Primary Care;Primary Care Physician;Protocols documentation;Provider;Puerto Rico;Quality of Care;Recording of previous events;Recovery;recruit;Research;Research Personnel;Resource-limited setting;Services;Shapes;Surgeon;System;telehealth;trend;United States Agency for Healthcare Research and Quality;Universities;Water

PROJECT_TITLE: Primary Care Transformation in Puerto Rico's Physician Organizations Following Hurricane Maria

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Complementary and Integrative Health;Digestive Diseases;Kidney Disease;Microbiome;Natural Products;Nutrition;Prevention

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project narrative It is proposed that by lowering indole and p-cresol in the intestines, the formation of indoxyl sulfate and p-cresol sulfate in the liver can be reduced, hence lowering two important protein- bound uremic retention solutes that otherwise cannot be efficiently removed with dialysis. We will utilize polymer and hydrogel engineering to tailor hydrogel beads that can be ingested as bubble teas, and later be excreted intact from the GI tract. The beads will contain immobilized bacteria and chemistry to degrade indole, p-cresol or their amino acid precursors to non-toxic, beneficial, or probiotic components and their performance will be tested by mathematical modelling and in bioreactor assays which simulate the trip through the gut.

PI_NAMEs: WINKLER, MARI-KAROLIINA  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: absorption;Aerobic;Aftercare;Alkanesulfonates;American;Amino Acids;Bacteria;Binding;Binding Proteins;Biological;Biological Assay;Biomedical Engineering;Bioreactors;Blood;Blood Circulation;Cardiovascular system;Chemistry;Chronic Kidney Failure;Clinical;Colon;Communities;conventional therapy;Cresol;Data;Death Rate;design;Dialysis procedure;Diffuse;Diffusion;Dose;Drug Delivery Systems;End stage renal failure;Engineering;Environment;Environmental Engineering technology;Excision;Excretory function;experience;experimental study;Fermentation;Formulation;gastrointestinal system;Gastrointestinal tract structure;Gel;Goals;gut microbiome;high reward;high risk;Human Microbiome;Hydrogels;Immobilization;Impaired cognition;improved;improved outcome;In Vitro;Indican;Indoles;Ingestion;innovation;Intestines;Kidney;Kidney Diseases;Kidney Failure;Kinetics;Large Intestine;Liver;mathematical model;Mathematics;Measures;Membrane;Metabolism;Microbe;microbial;Microbiology;microbiome;microorganism;microorganism culture;Morbidity - disease rate;mortality;Needles;novel;Nutrient;Oxygen;particle;Patient-Focused Outcomes;Patients;Performance;Personal Satisfaction;pH gradient;Plasma;Plasma Albumin;Polymer Chemistry;Polymers;prebiotics;preservation;prevent;Probiotics;protein degradation;Research;Residual state;response;Running;scale up;Science;Side;Site;Small Intestines;solute;Source;Stomach;success;Sulfate;Swelling;symptomatology;Symptoms;Tea;Technology;Testing;Therapeutic;Time;tool;Toxic effect;Toxin;Uremia;Visualization

PROJECT_TITLE: Therapeutic bubble tea: Preventing the formation of uremic toxins with hydrogel immobilized microbes

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]