NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Rapid progressive forms of Alzheimer disease (AD) and AD-related dementias (ADRD) account for most cases of rapid progressive dementia in older patients, yet the factors that contribute to these extreme clinical phenotypes are unknown. The Biomarkers and Rates of Progression in Dementia (Bio-RaPID) study will enroll, evaluate, genetically characterize, and prospectively apply multimodal (imaging and biofluid) biomarkers to decipher the patient- and disease-specific factors that associate with rapid progressive AD/ADRD; these data will be compared with findings in patients with typical progressive AD/ADRD enrolled in Alzheimer Disease Research Center studies. Findings in prospectively evaluated patients will be validated through expansive proteomic analyses in cerebrospinal fluid from an independent cohort of patients with autopsy-confirmed rapid progressive AD/ADRD and results extended to identify biomarkers and disease-modifying targets for AD/ADRD.

PI_NAMEs: DAY, GREGORY SCOTT (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Acceleration;Age;alpha synuclein;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Apolipoprotein E;Autopsy;Biological Assay;Biological Factors;Biological Markers;biomarker identification;Blood;Blood Vessels;blood-based biomarker;Brain;brain magnetic resonance imaging;Cell Death;Cerebrospinal Fluid;Cerebrovascular Disorders;Clinic;Clinical;clinical application;clinical phenotype;Cognition;Cognitive;cognitive function;cohort;Collection;Creutzfeldt-Jakob Syndrome;Data;defined contribution;Dementia;demographics;Diagnostic;diagnostic strategy;Disease;Disease Progression;endophenotype;Enrollment;Epidermal Growth Factor Receptor;experience;Failure;fluorodeoxyglucose positron emission tomography;Frontotemporal Lobar Degenerations;Functional disorder;Genetic;genetic variant;genome sequencing;Glial Fibrillary Acidic Protein;Health;Image;immune activation;Impaired cognition;in vivo;Individual;Injury;Integrins;Lewy Body Disease;Light;Link;Literature;Macrophage Colony-Stimulating Factor Receptor;Magnetic Resonance Imaging;Measures;Mediating;Medical;Medical History;Molecular;multimodality;Nerve Degeneration;neurofilament;neuroinflammation;Neuronal Injury;neuropathology;novel;older patient;Older Population;osteopontin;Participant;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Positron-Emission Tomography;Predisposition;Process;prospective;protein TDP-43;Proteins;Proteomics;Protocols documentation;Receptor Signaling;recruit;Research;research clinical testing;Risk Factors;Sampling;sex;Site;social health determinants;standard measure;structural determinants;Structure;Sum;Symptoms;Synapses;synaptic function;tau Proteins;Tauopathies;Telemedicine;Underrepresented Populations;Vascular Diseases;whole genome;Work

PROJECT_TITLE: Bio-RaPID: Biomarkers and Rates of Progression In Dementia.

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Food Allergies;Health Services;Pediatric

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Inadequate medication adherence is common in adolescents with eosinophilic esophagitis - a chronic inflammatory condition of the esophagus - and leads to poor health outcomes and increased healthcare spending. This proposal seeks to conduct pilot testing of a new medication adherence intervention for adolescents with eosinophilic esophagitis and measure the impact of dupilumab (a newly approved biologic therapy for eosinophilic esophagitis) on nonadherent adolescents. Results of this proposal have widespread applicability to all adolescents with chronic diseases for whom medication nonadherence remains an important public health concern.

PI_NAMEs: MEHTA, POOJA  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Address;Adherence;adherence rate;Adolescent;Adult;Affect;Allergic;Anesthesia procedures;behavior change;Behavioral;Biological Response Modifier Therapy;Bolus Infusion;career;career development;Cessation of life;Child;Child Health;Childhood;Chronic;Chronic Disease;Clinical;Clinical Trials;Clinical Trials Design;Colorado;Community Hospitals;Consolidated Framework for Implementation Research;cost;Coupled;Data;data integration;Deglutition;design;Development Plans;Disease;disease model;disease natural history;Disease Surveillance;Dissemination and Implementation;dissemination science;Dose;Drug Prescriptions;Effectiveness of Interventions;effectiveness/implementation study;effectiveness/implementation trial;Electronic Health Record;Elements;Endoscopy;Environment;Eosinophilic Esophagitis;Eosinophilic Gastrointestinal Disease;Esophageal Diseases;Esophageal Stenosis;Esophagus;FDA approved;Food;forgetting;Foundations;Future;Gastrointestinal Diseases;Goals;Habits;Health;Healthcare;Healthcare Systems;Histologic;Hospitals;human old age (65+);Immune;implementation science;improved;improved outcome;Incidence;Individual;Inflammatory;Injectable;Injections;innovation;Institution;Intervention;intervention delivery;K-Series Research Career Programs;Laboratories;Measures;Mediating;Medical;medication compliance;medication nonadherence;Mentorship;Methodology;mHealth;Morbidity - disease rate;mortality;multidisciplinary;Nurses;Observational Study;Online Systems;Oral Medicine;Outcome;Outcomes Research;Patient Noncompliance;Patients;Pediatric Hospitals;pediatric patients;Pediatrics;Pharmaceutical Preparations;Pilot Projects;pilot test;pilot trial;poor health outcome;Population Heterogeneity;pragmatic trial;prevent;professor;programs;prospective;Prospective, cohort study;prototype;Public Health;Quality of life;randomized trial;Randomized, Controlled Trials;Regimen;Research;Research Design;Research Personnel;Research Proposals;Research Training;Role;Route;safety net;Schedule;Schools;Science;Scientist;Secondary to;Self Management;skills;Steroids;symptom management;symptomatology;Techniques;Technology;tertiary care;Testing;Therapeutic;Time;tool;Training;treatment adherence;United States;Universities;usability;user centered design;Variant;Work

PROJECT_TITLE: Innovations in treatment adherence in pediatric eosinophilic esophagitis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Nutrition;Pediatric;Prevention;Women's Health Research

ORG_CITY: ITHACA

ORG_DEPT: NUTRITION

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: NARRATIVE Insufficient human milk production is a major cause of mothers stopping to breastfeed early, having major consequences on maternal and infant health. Leveraging the applicant's expertise in molecular biology and clinical dietetics, this study aims to understand the physiological regulation of milk production, including the functional characterization of novel milk production associated gene, C6orf15, assessment of optimal breast pumping protocols, and investigation of molecular mechanisms underlying increased milk production. The research combines clinical and molecular approaches, with the potential to significantly improve the diagnosis and treatment of insufficient milk production, ultimately benefiting both mothers and infants.

PI_NAMEs: GOLAN MAOR, YARDEN  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: 3-Dimensional;Address;Adherence;Affect;Anxiety;Award;Bilateral;Blood;Blood specimen;Breast Feeding;breast pump;Candidate Disease Gene;Cause of Death;Cell Line;Cells;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Research;Clinical Trials;cohort;Controlled Environment;cost;Data;design;Diagnosis;Dietetics;differential expression;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;Exclusive Breastfeeding;experience;Failure;Frequencies;gene function;Genes;Genetic Transcription;genomic data;Genomics;Growth;Growth and Development function;Health;Hormonal;hormone regulation;Hour;Human Milk;human RNA sequencing;improved;In Vitro;Individual;Infant;Infant Health;Infant Mortality;infant nutrition;inflammatory marker;insight;Intervention;Investigation;Lactation;Macronutrients Nutrition;Mammary gland;Maternal Health;maternal wellbeing;Measurement;Measures;Medical Records;Mental Depression;Milk;milk production;Milk Proteins;milk supply;milk volume;Molecular;Molecular Biology;Mothers;mouse model;Mus;novel;Nutrient;Organoids;overexpression;Participant;Pathway interactions;Phase;Phenotype;Physiological;Prolactin;Protein Secretion;Protocols documentation;public health research;Pump;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;Regulation;Reporting;Research;Research Activity;Research Proposals;response;Role;Sampling;single-cell RNA sequencing;System;Techniques;Testing;tool;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;Treatment Protocols;United States;Weight;Weight Gain;Women's Health;Work

PROJECT_TITLE: Molecular mechanisms for regulation of volume and nutrient content of human milk and their relationship with infant growth

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Emergency Care;Health Services;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE The public health significance of GAPcare II is immense as it proposes a multidisciplinary care coordination program that addresses the Healthy People 2020 goals of preventing and reducing injuries and enhancing life independence among older adults. This project is directly responsive to NIA’s “Strategic Directions for Research on Aging”, section B5: Identify, analyze, and track changing patterns of disability and mortality for older adults and better understand factors contributing to these patterns. Dr. Goldberg’s technology-assisted fall prevention intervention could provide a model of care to reduce subsequent falls in high-risk emergency department seniors and supports the further training of Dr. Goldberg to become a leader in geriatric emergency care.

PI_NAMEs: GOLDBERG, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Address;Aging;Apple watch;Award;care coordination;career;Caregivers;Caring;Clinical Trials;collaborative approach;Data;Data Analyses;digital health;disability;Elderly;Emergency Care;Emergency Department patient;Emergency department visit;Emergency Medicine;Epidemiologist;Epidemiology;Fall prevention;fall risk;falls;field study;Future;Goals;Health Policy;Health Services;Health Services Research;Healthy People 2020;high risk;Home;Impaired cognition;Injury;Intervention;Investigation;Leadership;Life;Measures;Medication Management;Mentors;Mentorship;Methods;Modeling;mortality;multidisciplinary;older adult;Outcome;Outpatients;Patients;Pattern;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;physical therapist;Physicians;Pilot Projects;Policies;prevent;preventive intervention;programs;Protocols documentation;Public Health;Qualitative Research;Randomized, Controlled Trials;Recurrence;Rehabilitation therapy;Research;Research Personnel;Resources;Safety;Scientist;Specialist;Technology;Testing;Training;treatment as usual;usability;Work

PROJECT_TITLE: GAPcare II: The Geriatric Acute & Post-acute Care Coordination Program for Fall Prevention in the Emergency Department


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: Integration of reproduction and metabolism is necessary for species survival. This proposal aims to further our understanding of the integration of energy homeostasis with reproductive function, and determine the mechanism(s) by which the melanocortin 3 receptor (MC3R) is involved in integrating information about metabolic state with development and control of the hypothalamic-pituitary-gonadal axis. Identifying and understanding the role of MC3R in reproductive neuroendocrinology may lead to therapeutic approaches and preventative strategies for treating reproductive disorders, such as PCOS, and delayed reproductive maturation.

PI_NAMEs: PORTER, DANIELLE TIFFANY (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: 3-Dimensional;Address;Agonist;Anatomy;Animals;antagonist;Biological Models;Brain;Brain imaging;career;Cell Nucleus;Cells;Communication;Competence;Complement;Cone;Data;Data Set;Development;Disease;ESR1 gene;Estrus;Exhibits;experience;Fasting;Feeding behaviors;Female;Fiber;Foundations;Four Core Genotypes;Frequencies;Functional disorder;gamma-Aminobutyric Acid;gonad function;Gonadal Steroid Hormones;Grant;Homeostasis;Human;hypothalamic pituitary gonadal axis;Hypothalamic structure;In Situ Hybridization;KISS1 gene;Length;Light;Luteinizing Hormone;male;Maps;Mediating;Melanocortin 3 Receptor;Mentors;Mentorship;Messenger RNA;Metabolic;Metabolism;Microscopy;Modeling;mouse model;Mus;Mutation;neural circuit;neural patterning;Neuroanatomy;Neuroendocrinology;Neurons;Neuropharmacology;neurophysiology;Neurosecretory Systems;novel;Optics;Pathway interactions;Pattern;Peripheral;pharmacologic;Pharmacology;Physiologic pulse;Physiological;Physiology;Pituitary Gland;Play;Ploidies;Positioning Attribute;Prevention strategy;Principal Investigator;programs;Puberty;receptor;Receptor Cell;receptor expression;receptor function;Regulation;Reproduction;reproductive;reproductive axis;reproductive development;reproductive function;reproductive neuroendocrinology;reproductive system disorder;Research;response;Role;sex;Sex Chromosomes;Sex Differences;sexual dimorphism;Signal Transduction;Site;Structure of nucleus infundibularis hypothalami;System;Tamoxifen;Testing;Therapeutic;therapeutic target;tool;Training;trend;Visualization

PROJECT_TITLE: Role of the Melanocortin-3 Receptor in Regulation of the HPG Axis

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-C (02)]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative The number of older adults suffering from Alzheimer’s disease is expected to rise unless new treatments are developed which can prevent or delay the onset of dementia. Investigating the molecular and cellular mechanisms that support resiliency to Alzheimer’s disease will reveal new therapeutic targets to halt disease progression in at risk patients.

PI_NAMEs: HERSKOWITZ, JEREMY H. (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta accumulation;abnormally phosphorylated tau;Address;Affinity;age related;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Anatomy;Automobile Driving;Autopsy;Axon;Binding Proteins;Biochemistry;Brain;Brain region;Cells;Cessation of life;Clinical;Cognitive;cognitive ability;cognitive function;cognitive performance;Communities;Data;Dementia;Dendrites;Dendritic Spines;density;Disease Progression;Electrophysiology (science);entorhinal cortex;Environment;Exhibits;Functional disorder;Genetic;Goals;high risk;Human;Human Cell Line;human data;human tissue;Impaired cognition;Individual;innovation;Investigation;Knowledge Portal;Link;Maintenance;Memory;Memory Loss;memory process;Microscopy;Microtubule Stabilization;Microtubules;Molecular;Morphology;Neurofibrillary Tangles;neuronal cell body;Neurons;neuropathology;new therapeutic target;normal aging;novel;older adult;Older Population;Pathologic;Pathology;Pathway interactions;Patients;Physiological;Population;preservation;prevent;Proteins;Proteomics;religious order study;Research;resilience;Risk;Sampling;Senile Plaques;Severities;Synapses;Systems Biology;tau aggregation;tau mutation;tau Proteins;Temporal Lobe;Testing;Therapeutic;therapeutic protein;Time;Tissue Sample;Toxic effect;trait;Universities;Vertebral column;Work

PROJECT_TITLE: Synaptic Resilience to Tau in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Patient Safety;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE Heart failure is a major, common, and costly public health problem in the United States, and despite the existence of several proven, guideline-recommended medications to reduce mortality and hospitalization, many patients are not prescribed or do not fill these medications. This study aims to quantify the impact of restrictive drug coverage policies, such as copayment and prior authorization, on gaps and inequities in prescribing, adherence, and outcomes for patients with heart failure. Our findings could inform policy-makers, health systems, and clinicians on ways to improve care and reduce inequities for patients with heart failure.

PI_NAMEs: MUKHOPADHYAY, AMRITA  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Adherence;Algorithms;Angiotensin Receptor;Behavior;black patient;cardiovascular health;Cardiovascular system;career development;Caring;Censuses;Cessation of life;Clinical;Cluster randomized trial;Coinsurance;Competence;copayment;cost;Cost Sharing;Data;Data Science;Databases;Drug Prescriptions;effective therapy;Effectiveness of Interventions;EHR research;Electronic Health Record;Eligibility Determination;Equity;Ethnic Origin;evidence base;experience;expiration;Formularies;Foundations;Future;gender disparity;geographic disparity;Glucose;Goals;Guidelines;Health equity research;Health Expenditures;health inequalities;health information technology;Health Services Research;Health system;Heart failure;heart failure with reduced ejection fraction;Heart Rate;high risk;hospital readmission;Hospitalization;implementation research;implementation science;improved;Inequity;inhibitor;Insurance;Intervention;Investigation;Language;Legal patent;Life;Low income;low socioeconomic status;Measures;medication compliance;Medicine;Mentors;Mentorship;Methodology;Methods;Modeling;mortality;National Heart, Lung, and Blood Institute;Neighborhoods;Neprilysin;Outcome;Patient Compliance;patient subsets;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Pharmacy facility;Physicians;pilot test;Policies;Policy Maker;Population;Population Database;Positioning Attribute;preventable death;prior authorization;Provider;Public Health;Publishing;Quality of life;Quasi-experiment;Race;racial disparity;Recommendation;Regimen;Research;Research Personnel;Risk;sex;shared decision making;skills;socioeconomic disparity;Socioeconomic Status;Sodium;Strategic vision;Subgroup;symporter;System;Time;Training;Uninsured Medical Expense;United States;Vulnerable Populations

PROJECT_TITLE: Impact of Restrictive Drug Coverage Policies on Heart Failure Care

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (MA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Disability Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative This project aims to develop an innovative analytical toolbox designed to address multifaceted statistical challenges inherent in the analysis of real-world data. Utilizing this toolbox to analyze Medicare data will yield insights into the identification of high-risk subgroups and hospital-level factors partially driving poor post- fracture recovery trajectories for older adults living with ADRD. Consequently, these findings will enhance predictive capabilities for multivariate and multilevel outcomes, enabling the development of personalized caregiving strategies for new patients.

PI_NAMEs: CHEN, CHIXIANG  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Address;Aging;aging in place;Algorithms;Alzheimer's disease related dementia;American Hospital Association;Automobile Driving;caregiving;Caring;Cessation of life;Characteristics;Clinical;Cognitive;cohort;Communities;comparative effectiveness;Complex;coping;cost;Data;Data Science;Data Sources;Death Rate;Dependence;design;Development;Diagnosis;disability;Elderly;Exclusion;experience;Fracture;functional independence;Future;Goals;Health;Health care facility;Health system;Heterogeneity;high dimensionality;high risk;high risk population;Hip Fractures;Home;hospital care;Hospitals;human old age (65+);improved;Individual;innovation;insight;Interdisciplinary Study;Intervention;Joints;Lead;Link;Machine Learning;machine learning algorithm;machine learning method;Medicare;Medicare claim;Methodology;Methods;minimal risk;Modeling;Modernization;mortality;mortality risk;multidimensional data;multimodality;neglect;novel;older adult;Outcome;Outcome Measure;outcome prediction;Outcomes Research;patient oriented;patient subsets;Patient-Focused Outcomes;Patients;personalized care;personalized health care;personalized predictions;Population;Positioning Attribute;pragmatic intervention;pro-aging;Publishing;Quality of life;randomized, clinical trials;Recovery;Research;Research Personnel;Resource Allocation;Resources;Risk;shared decision making;Statistical Bias;Statistical Methods;structured data;Subgroup;Surveys;symposium;tool;trend;uptake;Variant;Work

PROJECT_TITLE: Developing a Novel Analytical Toolbox to Tackle Multifaceted Statistical Challenges in Analyzing Post-Fracture Recovery Trajectories in Older Adults with ADRD

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Columbus

ORG_DEPT: PSYCHOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: The persistence of neural stem cells in isolated niches of the adult brain offers a potentially unique source of plasticity and regeneration. Understanding how neural stem cells contribute to adult brain plasticity is critical to determining the health-relevance of these cell populations. The proposed experiments will dissect the functional role of neural stem cell secreted proteins in modulating the physiology and behavioral function of the adult hippocampus, a brain region which mediates essential memory and affect functions which are impaired in numerous brain diseases and injuries.

PI_NAMEs: KIRBY, ELIZABETH DIANA (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Acute;Adult;adult neurogenesis;Affect;Amino Acids;Astrocytes;autocrine;Behavioral;behavioral response;Brain;Brain Diseases;brain health;Brain Injuries;Brain region;cell type;Cells;Cognitive;Collection;Coupled;cytokine;Cytoplasmic Granules;Data;dentate gyrus;Dimensions;Disease;emotion regulation;emotional functioning;Emotions;excitotoxicity;experimental study;Exposure to;Functional disorder;functional improvement;Gatekeeping;Genetic Code;Goals;Growth Factor;Health;Hippocampus;Homeostasis;Impairment;indexing;Individual;Influentials;Injury;insight;knock-down;life span;Literature;Mammals;Mediating;Memory;Modeling;Natural regeneration;nerve stem cell;neural;neurogenesis;Neurons;Neurophysiology - biologic function;paracrine;Parahippocampal Gyrus;Pattern;Physiology;pleiotropism;Population;Process;Production;progenitor;Protein Isoforms;Protein Secretion;Proteins;Recovery;Regulation;Reporting;Research;response to injury;Role;Shapes;Signal Transduction;Source;source localization;stem;stem cell proliferation;stem cells;Testing;Therapeutic;Time;tissue regeneration;Tissues;Transgenic Organisms;Undifferentiated;Vascular Endothelial Growth Factors;viral rescue;Work

PROJECT_TITLE: Regulation of adult hippocampal function by the neural stem and progenitor cell secretome

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The ability to maintain relevant information necessary to make decisions and continuously update our autobiographies as we amass experience from childhood into adulthood depends on the medial temporal lobe and prefrontal cortex. By measuring electrical activity directly from the human brain, the proposed research will determine the mechanisms by which these regions interact to form and maintain memories in real time, and identify sources of developmental variability in these mechanisms from childhood into adulthood. The outcomes will increase understanding of how the brain implements normal memory and how brain circuits may go awry in disordered behavior, laying the foundation for translational work aimed at improving memory in populations suffering from disease or injury.

PI_NAMEs: JOHNSON, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Adolescent;Adult;Age;age related;age related decline;aged;Aging;aging population;Alzheimer's Disease;Animals;Autobiography;Behavior;Behavior Disorders;behavior prediction;Behavioral;Behavioral Model;Brain;career;career development;Child;Childhood;Clinical;Cognition;comparative;Data;Data Analyses;Decision Making;Dementia;Deterioration;Development;Development Plans;Disease;Electroencephalography;Electrophysiology (science);Equilibrium;Ethics;experience;flexibility;Foundations;Frequencies;frontal lobe;Future;Future Teacher;Goals;Health;Hippocampus;Human;Human Activities;human model;improved;indexing;Individual;Individual Differences;Injury;Knowledge;Laboratories;Life;life span;Link;Maintenance;Maps;Measures;Medial;medial temporal lobe;Memory;Memory Loss;Mentors;Mentorship;Nervous System Disorder;neural;neural circuit;neural network;Neurocognitive;Neurologic;neuromechanism;Neurons;neurophysiology;Neurophysiology - biologic function;neuropsychiatric disorder;Neurosciences;neurosurgery;Noise;nonhuman primate;novel;Outcome;Patients;Pattern;Performance;Phase;Physiology;Population;Positioning Attribute;Predisposition;Prefrontal Cortex;Principal Investigator;programs;Reporting;Research;Research Personnel;responsible research conduct;Role;Running;Scalp structure;Seizures;Series;Short-Term Memory;Signal Transduction;skills;Source;spatiotemporal;statistics;Stroke;Structure;Study models;success;System;Theta Rhythm;Time;Training;Traumatic Brain Injury;Update;Work

PROJECT_TITLE: Measuring Electrical Activity from the Human Brain to Predict Memory Formation and Behavior Across the Lifespan


ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative Neurodegenerative diseases and trauma to the CNS are major public health issues that afflict more than 50 million Americans yearly. This research program will lay the foundation for broad based and preventative therapies that will reduce the physical, emotional and financial impacts of these diseases on the public.

PI_NAMEs: GRILL, BROCK  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;American;Autophagocytosis;Autophagosome;Axon;axonal degeneration;Binding;Binding Proteins;Biochemical;Biochemistry;Biology;Caenorhabditis elegans;candidate identification;CDK5 gene;Cells;Code;Complex;CRISPR/Cas technology;Darkness;design;Development;Disease;Emotional;Engineering;Event;experimental study;Foundations;Funding;Genetic;genetic approach;genetic testing;Goals;Growth;Health system;Human;in vivo;inhibition of autophagy;inhibitor;insight;Integrins;interest;knock-down;Knowledge;Ligase;Link;loss of function;Mass Spectrum Analysis;Mediating;member;Molecular;multicatalytic endopeptidase complex;mutant;Nature;Nematoda;Nervous System;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuron development;Neurons;novel;novel therapeutics;Organism;Orthologous Gene;Outcome;Phosphorylation;Phosphorylation Site;Phosphotransferases;Play;Preventive therapy;Process;programs;Protein Family;Proteins;Proteomics;Public Health;Receptor Signaling;Research;resilience;Role;Sampling;Signal Transduction;Signaling Protein;SKP Cullin F-Box Protein Ligases;Structure;Synapses;Synaptic plasticity;synaptogenesis;System;Technology;Testing;Trauma;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Mechanisms of synapse formation and axon termination in C. elegans


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative COVID-19 vaccines are unable to prevent widespread infection with new viral variants, as even the updated vaccine tends to boost pre-existing antibodies to old strains instead of causing new antibodies to form against current strains. We designed a vaccine that causes antibodies to form to only one area on the virus: a weak spot that is identical in all strains. We will test and optimize this vaccine in mice, with the ultimate goal of using it in humans as a more effective booster vaccine against all viral strains.

PI_NAMEs: STAMPFER, SAMUEL DAVID (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;Absenteeism at work;Adoptive Transfer;Amino Acid Receptors;Amino Acids;Animals;Anti-viral Agents;Antibodies;antibody engineering;Antibody Response;Antigens;Area;asymptomatic COVID-19;B-Lymphocytes;Binding;Biological Assay;Biometry;booster vaccine;career;career development;Cell Separation;Cessation of life;Chimeric Proteins;Collaborations;Coronavirus;COVID-19;COVID-19 vaccination;COVID-19 vaccine;cross reactivity;cytokine;Data;design;Development;Development Plans;Economics;efficacy testing;Engineering;Ensure;Enzyme-Linked Immunosorbent Assay;Epitopes;Equipment;experimental study;Family;FDA approved;Funding;Future;Goals;Grant;Human;Immune;Immune response;Immunity;Immunize;Immunocompromised Host;immunogenic;immunogenicity;Immunology;improved;Individual;Infection;Infection prevention;Influenza;innovation;K-18 conjugate;Learning;Length;Light;Link;Measures;Mentors;Mentorship;Messenger RNA;Methodology;Minority Groups;Monoclonal Antibodies;monoclonal antibody production;Morbidity - disease rate;Mus;Mutate;Mutation;neutralizing antibody;nonhuman primate;novel coronavirus;online course;Paramyxovirus;pathogenic virus;Persons;Physicians;Population;Positioning Attribute;Post-Acute Sequelae of SARS-CoV-2 Infection;pre-clinical;prevent;Productivity;prophylactic;Protein Engineering;protein structure;Proteins;prototype;receptor binding;Research;Research Personnel;response;RNA vaccine;Sarbecovirus;sarbecovirus vaccine;SARS-CoV-2 B.1.351;SARS-CoV-2 infection;SARS-CoV-2 spike protein;SARS-CoV-2 variant;scaffold;Scientist;Seasons;Secondary Immunization;Severe Acute Respiratory Syndrome;Site;skills;Spottings;Stains;Structure;T cell response;T-Lymphocyte;Techniques;Testing;Therapeutic;therapeutic evaluation;Training;transmission process;Update;Vaccinated;Vaccination;vaccine development;vaccine efficacy;vaccine evaluation;vaccine-induced antibodies;Vaccines;vaccinology;Variant;variants of concern;vector;Viral;viral transmission;Viral Vaccines;Virus;Work;Writing

PROJECT_TITLE: Induction of Broad Sarbecovirus Immunity Via A Vaccine Engineered From SARS-CoV-2 Heptad Repeat 1

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Biomedical Imaging;Chronic Pain;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Osteoarthritis;Pain Research

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative By implementing the developed approaches, the research team aims to attain increased accuracy in identifying knees with a high risk of incident frequent knee pain in specific locations, along with the MRI-defined determinants associated with these knee pain patterns. It is expected that the proposed studies will provide timely information that can help identify patients who would be most likely to benefit from pharmacologic and non-pharmacologic interventions to prevent or slow the progression of knee osteoarthritis in clinical trials. The objectives of this proposal can thus potentially reduce the public health impact of knee osteoarthritis.

PI_NAMEs: GE, YONG ;KWOH, C KENT;SUN, XIAOXIAO  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Address;Affect;Big Data;Black Box;bone;Bone Marrow;Clinical Trials;Cohort Studies;Comprehension;Computer software;computerized tools;convolutional neural network;Data;Data Analyses;Data Set;deep learning;deep learning model;Degenerative polyarthritis;Dependence;design;Development;Diffuse;Disease;Ensure;Etiology;Evaluation;experience;Female;Goals;high risk;Hospitals;Image;Image Analysis;Individual;innovation;insight;Knee;Knee Osteoarthritis;knee pain;Lesion;Location;Machine Learning;Magnetic Resonance Imaging;male;Medical Imaging;Methods;Modeling;Musculoskeletal Diseases;Network-based;neural network;Nonpharmacologic Therapy;novel;Pain;Pain Map;Patients;Pattern;Performance;Pharmaceutical Preparations;pharmacologic;Phenotype;physically handicapped;predictive tools;Prevalence;prevent;Probability;Process;Property;Public Health;Pythons;Reporting;Research;Severities;Sex Differences;Shapes;Slice;Statistical Methods;Structural defect;Techniques;Tissues;tool;two-dimensional;Visit;Weight-Bearing state

PROJECT_TITLE: Computational Tools for Predicting and Understanding Knee Pain Spatial Patterns


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Data Science;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative This ambitious experimental and theoretical collaboration will investigate how internal states (such as task engagement) influence decision-making, and identify the underlying neural mechanisms. The proposed work will produce an integrated, circuit-level model that explains decision behavior and neural activity in healthy and autism model mice, which show a reduced ability to make decisions that take changing expectations into account. Decision-making is also impaired in addiction and schizophrenia, so a deeper understanding of brainwide decision-making circuitry may contribute to future research on ways to treat or mitigate these disorders.

PI_NAMEs: CHURCHLAND, ANNE KATHRYN;PANINSKI, LIAM M (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: addiction;Affect;Anatomy;Animals;Area;Axon;Bar Codes;Behavior;Behavioral;Biological Assay;Brain;Brain region;cell type;Collaborations;Collection;Communication;Computer Models;Computing Methodologies;Data Analyses;Data Collection;data infrastructure;data management;Data Science Core;Data Set;data sharing;Decision Making;deep learning;Development;Disease;Environment;Etiology;expectation;experimental study;flexibility;Food;Gene Expression;Genetic;Goals;Histology;Impairment;Individual;Infrastructure;International;Laboratories;large datasets;large scale data;Learning;Maps;Measurement;Measures;Methods;model of autism spectrum disorder;Modeling;Molecular;mouse model;Mus;Mutation;neural;neural circuit;neuromechanism;Neurons;next generation;novel;open source tool;optogenetics;Pattern;Population;Productivity;Protocols documentation;Reproducibility;Research;Research Personnel;Rewards;Schizophrenia;Standardization;Structure;Testing;theories;tool;Training;Ultrasonography;Wild Type Mouse;Work

PROJECT_TITLE: State-dependent Decision-making in Brainwide Neural Circuits


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: Invasive fungal infection caused by Aspergillus fumigatus is a leading cause of death for patients with lowered immune systems. Despite this high mortality, the fundamental mechanism of how A. fumigatus grows and invades the host tissue is not understood and this knowledge is critical to improving therapeutic treatment. Hyphal growth is crucial for A. fumigatus invasive disease and the proposed research will define the mechanism of how the critical PKA signaling pathway interacts with autophagy related proteins to regulate fungal invasive growth and disease.

PI_NAMEs: JUVVADI, PRAVEEN RAO;STEINBACH, WILLIAM J (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;anti-fungal agents;Aspergillosis;Aspergillus fumigatus;Autophagocytosis;Autophagosome;Biological;biological adaptation to stress;Biology;Carbon;Catabolic Process;Catabolism;Cause of Death;Cell Physiology;Cell Wall;combat;comparative;Critical Pathways;Cyclic AMP-Dependent Protein Kinases;cytokine;Data;Death Rate;Defect;Disease;Environment;environmental stressor;Expression Profiling;fungus;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Markers;Goals;Growth;Histologic;Immune;Immune response;Immune system;Immunocompromised Host;improved;Infection;insight;Invaded;Knowledge;Mediating;Metabolic;Metabolic Control;mimetics;Molecular;molecular dynamics;molecular modeling;mortality;mouse model;Mutagenesis;mutant;Mycoses;Nitrogen;novel;Nutrient;Organism;pathogen;Pathogenesis;pathogenic fungus;Pathway interactions;Patients;Phenotype;Phosphopeptides;phosphoproteomics;Phosphorylation;Phosphotransferases;Proteins;Proteome;Proteomics;Quantitative Reverse Transcriptase PCR;Recycling;Regulation;Research;Resistance;response;Role;Signal Pathway;Signal Transduction;Site;Site-Directed Mutagenesis;Specificity;Structure of parenchyma of lung;Testing;Therapeutic;therapeutically effective;Time;Tissues;translational study;Translations;Virulence

PROJECT_TITLE: PKA-Dependent Autophagy Control in Aspergillus fumigatus Pathogenesis

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer;Genetics

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Protein synthesis is misregulated in a number of diseases including cancer and neurodegeneration. We will investigate the features within mRNA that govern protein synthesis. Elucidating this process will lead to a better understanding of many cellular processes from development to adaptation and may also lead to more effective treatments for a variety of diseases.

PI_NAMEs: NIEDERER, RACHEL O. (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 5' Untranslated Regions;Affect;Award;Biochemical;biological adaptation to stress;candidate identification;Cell Physiology;Cells;Code;Development;differential expression;Disease;effective therapy;Elements;Enhancers;Exhibits;Exposure to;Genetic study;Health;Human;In Vitro;in vivo;interest;Malignant Neoplasms;Measures;Messenger RNA;mRNA Translation;Mutagenesis;Nerve Degeneration;novel;Nucleic Acid Regulatory Sequences;Oncogenic;Output;Pathogenicity;Pathway interactions;Phase;Process;Protein Biosynthesis;Proteins;Reader;recruit;Ribosomes;Role;Tissues;Translational Regulation;Translations;Untranslated RNA;Work

PROJECT_TITLE: Translational control by 5'-UTR elements

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE A major mechanism of immunotherapeutic resistance is immune suppression and major cell types that drive immune suppression are myeloid-derived suppressor cells (MDSCs), which compromise anti-cancer immunity. We identified a targeted metabolic vulnerability in MDSCs rendering them less suppressive, thus, raising tumor susceptibility to novel immunotherapy regimens. Here, we are investigating strategies to optimize this therapeutic paradigm in solid cancer models and the underlying immune mechanisms, which will have important translational implications in cancer patients with high MDSC burden.

PI_NAMEs: MORREALE, BRIAN GEORGE (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Acute Myelocytic Leukemia;Adjuvant;advanced disease;Anabolism;anti-cancer;anti-PD-1;anti-PD1 antibodies;Antitumor Response;Automobile Driving;Behavior;Binding Proteins;Biogenesis;Bone Marrow;Breast Cancer Patient;cancer immunotherapy;Cancer Model;Cancer Patient;cancer type;CD8-Positive T-Lymphocytes;Cell Physiology;Cell Reprogramming;cell type;Cellular biology;chemotherapy;Chemotherapy-Oncologic Procedure;Chronic;Clinical;Combination immunotherapy;combinatorial;cytotoxic CD8 T cells;Data;Dependence;design;Dihydroorotate dehydrogenase;Dihydroorotate Dehydrogenase Inhibitor;endoplasmic reticulum stress;Event;Factor X;Gene Expression;Goals;Immune;Immune checkpoint inhibitor;Immuno-Chemotherapy;Immunophenotyping;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;inhibitor;Investigation;Laboratories;Lead;Link;Malignant Neoplasms;Measures;Mediating;Metabolic;Modeling;Molecular;Monoclonal Antibody Therapy;mouse model;Myeloid Cells;Myeloid Progenitor Cells;Myeloid-derived suppressor cells;Neoadjuvant Therapy;novel;novel strategies;Oncologist;Operative Surgical Procedures;Paclitaxel;Pathway interactions;Patients;PD-1 blockade;PD-1/PD-L1;pharmacologic;Phase;Population Heterogeneity;Postdoctoral Fellow;pre-clinical;Predisposition;Production;programmed cell death protein 1;programs;Proteins;Publishing;Pyrimidine;pyrimidine metabolism;Regimen;Regulation;Research;Research Project Grants;Resistance;response;Signal Transduction;Solid;standard of care;survival outcome;T cell response;Testing;Therapeutic;therapeutic target;transcription factor;Translating;translational potential;translational therapeutics;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumorigenic;Work

PROJECT_TITLE: Metabolic Reprogramming of Myeloid Cells to Enhance Cancer Immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (M1)]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation;Stroke

ORG_NAME: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB

PHR: NARRATIVE There are a variety of motor deficits following stroke which present growing challenges to healthcare. Therapeutic practice with physical devices remains an exciting frontier for the recovery of function, but a critical question is precisely how such devices should be programmed. Here we investigate differences in outcomes using models that describe how a person responds to error during practice, and we evaluate how well these models can prescribe the best therapeutic training.

PI_NAMEs: PATTON, JAMES LANPHIER (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: 3-Dimensional;Agreement;Basic Science;Clinical;clinical application;clinical training;Clinical Trials;Communication;Complex;Computer Models;computer science;Computers;Data;Descriptor;Development;Devices;Diagnosis;effective therapy;effectiveness testing;efficacy evaluation;Engineering;Environment;experience;experimental study;Feedback;force feedback;Freedom;frontier;functional restoration;Goals;haptics;Healthcare;hemiparetic stroke;improved;Individual;innovation;Investigation;Knowledge;Learning;mathematical model;Methods;Modality;Modeling;Motor;motor deficit;motor learning;motor recovery;Motor Skills;Movement;neurological rehabilitation;Neuronal Plasticity;Outcome;Pathway interactions;Patients;Persons;Population;post stroke;Process;randomized, clinical trials;Recovery;Recovery of Function;Research;response;Robot;Robotics;Role;Sensory;Source;Stroke;stroke survivor;success;System;Techniques;Technology;Testing;Therapeutic;therapy design;tool;Touch sensation;Training;Transference;trend;User-Computer Interface;Variant;virtual;Vision;Visual;visual feedback;Work

PROJECT_TITLE: Error-enhanced Learning & Recovery in 2 & 3 Dimensions

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The quality of care for the over 800,000 residents of US nursing homes (NH) with Alzheimer's disease or related dementias (ADRD) is variable and outcomes are poor. We workforce with The propose to characterize the – primarily composed of NPs and physicians that provides general medica l care to NH residents ADRD and measure the outcomes of NH residents with ADRD under different NH clinician care models. overarching NH clinician - goal of this project is to improve the quality of care for NH residents with ADRD by evaluating and disseminating information on high-performing NH clinician care models.

PI_NAMEs: RYSKINA, KIRA L (contact)

PROGRAM_OFFICER_NAME: KELLER, CHANDRA

PROJECT_TERMS: Acute;Admission activity;advanced directive;Alzheimer's disease related dementia;Ambulatory Care;Analgesics;Area;care coordination;care costs;care providers;Caring;Characteristics;Chronic;Clinical;Communication;Communities;community setting;Complex;cost;cost comparison;Data;Data Set;Dementia;Diagnosis;Drug Prescriptions;end of life;experience;Family;functional decline;functional status;Goals;Group Practice;Growth;Health;Healthcare;Home Nursing Care;Hospitalization;improved;Individual;Intervention;Link;Literature;Measures;Medical;Medicare;Medicare claim;memory care;Methods;Minor;Modeling;novel;Nurse Practitioners;nursing care quality;Nursing Homes;Nursing Models;older adult;Outcome;Outcome Measure;pain symptom;Patients;payment;Pharmaceutical Preparations;Physician Assistants;Physicians;Play;Policies;Policy Maker;Population;Procedures;Process;Prognosis;Provider;Quality of Care;Regulation;Role;Sampling;Surveys;Time;Visit;Visiting Nurse;Work

PROJECT_TITLE: Advanced Provider Care Models and Health Outcomes of Nursing Home Residents with Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


NIH_SPENDING_CATS: Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: PROVIDENCE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Voltage-gated calcium ion channels are the gatekeepers that sit at the junction of the peripheral and central nervous systems. Our research is focused on the importance of these channels in normal and abnormal pain. We hope to generate new strategies to mitigate some forms of chronic pain experienced by millions of people.

PI_NAMEs: LIPSCOMBE, DIANE  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: access restrictions;Address;Afferent Neurons;Architecture;Behavior;Behavioral;Binding;Binding Proteins;bisulfite sequencing;Brain;Calcium;Calcium Channel;Calcium Signaling;Capsaicin;CCCTC-binding factor;Cell Line;Cells;Central Nervous System;Chromatin;chronic pain;chronic painful condition;Collaborations;defined contribution;Detection;Disease;DNMT3a;Enzymes;Epigenetic Process;Event;Exons;experience;experimental study;Functional disorder;Gatekeeping;Gene Chips;Genes;Genetic;genetic approach;Glutamates;healing;Hypersensitivity;improved;in vivo;in vivo calcium imaging;in vivo imaging;Inflammation;Injury;Investigation;Ion Channel;Link;Location;Maintenance;Mammalian Cell;Measures;mechanical signal;Mechanical Stimulation;mechanical stimulus;Mechanics;Mechanoreceptors;Messenger RNA;Methodology;Methods;Methylation;Modeling;Molecular;Morphine;Mouse Strains;mRNA Precursor;Nerve;Nerve Endings;nerve injury;Nervous System;Neurons;Neurosciences;neurotransmission;Nociception;Nociceptors;novel;optogenetics;P-Q type voltage-dependent calcium channel;Pain;pain model;pain perception;Pattern;Peripheral;Peripheral nerve injury;Peripheral Nerves;Peripheral Nervous System;Persons;pharmacologic;Pharmacology;presynaptic;Process;Property;Protein Isoforms;Proteins;Research;response;RNA;RNA Splicing;Role;Sensory;sensory system;Signal Transduction;Site;Skin;Specificity;Spinal cord posterior horn;Stimulus;Substance P;Synapses;synaptic function;Testing;tissue injury;Touch sensation;transmission process;treatment strategy;United States;voltage;Zinc Fingers

PROJECT_TITLE: Voltage-Gated Calcium Channels in Nociceptors and Mechanoreceptors

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Influenza-associated secondary pneumococcal infections are dreaded complications that cause serious illnesses and significantly contribute to Influenza related mortality. Highly endocytic Microfold cells arise in the lower respiratory epithelium during the resolving phase of Influenza linked inflammation when susceptibility to secondary pneumococcal pneumonia is highest. This proposal will unravel the pathologic role of lung Microfold cells as entry portals for pneumococcal invasion and will have the potential to develop novel therapeutic avenues for targeting virus-associated secondary infections.

PI_NAMEs: SURVE, MANALEE V (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 1918 influenza pandemic;Ablation;Advisory Committees;airway epithelium;Antigens;Bacterial Infections;Bacterial Pneumonia;Biology;Boston;Bronchus-Associated Lymphoid Tissue;career;career development;CCL20 gene;Cell Physiology;Cells;chemokine;co-infection;Complement;Complement 3d Receptors;Coupled;CRISPR/Cas technology;Data;Dendritic Cells;design;Development;Disease;Endosomes;Engineering;Ensure;Epithelium;Etiology;Faculty;Functional disorder;Gene Expression;Genes;Genetic Models;Genetically Engineered Mouse;Goals;Gut associated lymphoid tissue;imaging platform;Immune;immune cell infiltrate;Immunity;Immunologic Surveillance;Immunologics;immunoregulation;In Vitro;in vitro Model;in vivo Model;Incidence;Infection;Inflammation;Influenza;influenza infection;innovation;Intestines;Invaded;Knowledge;Link;Lung;Lung infections;lung regeneration;M cell;MEL Gene;Mentorship;migration;Modeling;Molecular;mortality;mouse model;Mucosal Immunity;Mus;next generation;novel;novel therapeutic intervention;novel therapeutics;pandemic influenza;pathogen;Pathogenicity;Pathologic;Pathway interactions;Peyer's Patches;Phase;Play;Pneumococcal Infections;Pneumococcal Pneumonia;Pneumonia;Predisposition;prevent;Proliferating;Property;receptor;Recycling;Regenerative Medicine;Reporting;Research;Research Personnel;Research Proposals;Resolution;Role;Route;Sampling;Scientist;Seasons;secondary infection;Secondary to;Sepsis;single-cell RNA sequencing;skills;Streptococcus pneumoniae;superinfection;tenure track;Testing;Therapeutic;trafficking;Training;transcriptome;transcriptomics;transcytosis;Transgenic Mice;uptake;Virus;Virus Diseases;Work

PROJECT_TITLE: Functions and Mechanisms of Lung Microfold cells during Invasive Pneumococcal Disease

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (MA)]


NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Childhood Injury;Genetics;Human Genome;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Unintentional Childhood Injury

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: The project is intended to provide a new understanding of neuronal and glial development during late gestation and the early postnatal period. These are critical times in human neonatal brain development that are vulnerable to injuries, such as hypoxia, and can result in lifelong neuro-cognitive disabilities, including cerebral palsy and epilepsy.

PI_NAMEs: ALVAREZ-BUYLLA, ARTURO  (contact)

PROJECT_TERMS: ADGR1 gene;Amygdaloid structure;angiogenesis;Area;Autopsy;Blood Vessels;Brain;Brain Injuries;Brain Ischemia;brain tissue;Cell Communication;cell growth regulation;Cell Maturation;Cell Nucleus;Cells;Cerebral Palsy;Child;cognitive disability;Data;Development;Diagnosis;disability;Disease;Early treatment;Endothelial Cells;Epilepsy;Event;fetal;Financial Hardship;Foundations;frontal lobe;Funding;Gene Expression Profile;Genetic;glial cell development;Goals;Grant;Health;Heterogeneity;Histologic;Human;human migration;Hypoxia;In Situ Hybridization;Infant;Injury;insight;Interneurons;Invaded;Life;Ligands;Maps;Mediating;Microglia;migration;Morphology;Nature;Neonatal;neonatal brain;neonatal brain development;Neonatal Brain Injury;neonatal human;neonatal hypoxic-ischemic brain injury;nerve stem cell;Nervous System Trauma;neural circuit;Neurocognitive;neurodevelopment;neurogenesis;neurogenetics;neuron development;Neurons;neuropathology;Neurophysiology - biologic function;Newborn Infant;oligodendrocyte progenitor;Oligodendroglia;online resource;Pathway interactions;Perinatal;Play;postnatal;postnatal period;precursor cell;Pregnancy;Process;Production;programs;recruit;Regulation;Research;Research Personnel;Research Training;Resource Sharing;Resources;Rodent;Role;Route;scaffold;Science;Services;single nucleus RNA-sequencing;single-cell RNA sequencing;social;Specimen;stem cell expansion;stem cell migration;stem cell proliferation;synaptogenesis;System;training opportunity;transcriptomics;VEGFA gene;white matter

PROJECT_TITLE: Regulation of cellular pathways in human brain development


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Sexually Transmitted Infections;Urologic Diseases

ORG_CITY: LEXINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Chlamydia species infect a wide range of mammalian hosts and deploy an array of anti-host proteins to promote the ability to cause disease. While many of these proteins are conserved across species, some have diverged and are likely to contribute to species-specific differences in infection. This proposal contains work designed to characterize a group of those variable proteins and elucidate specific contributions to chlamydial disease.

PI_NAMEs: FIELDS, KENNETH A (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Actins;Address;Affect;Animal Model;Antibodies;Applied Genetics;Biochemical;Biological Assay;Biology;Caspase;Cell Culture Techniques;cell type;Cells;Cellular biology;Chlamydia;Chlamydia Infections;Chlamydia muridarum;Chlamydia trachomatis;Chlamydiaceae;Chlamydiales;Chlamydophila pneumoniae;Chromosomes;Chronic;Code;comparative;Cytoskeleton;Cytotoxin;Data;design;Disease;Engineering;Epithelial Cells;Eukaryotic Cell;Exhibits;experience;Family;Family member;Foundations;Gene Order;Genes;Genetic;genital infection;Genitourinary system;glycosyltransferase;Goals;Guanosine Triphosphate Phosphohydrolases;Homologous Protein;Human;human disease;human pathogen;in vivo;Infection;Inflammation;intracellular parasitism;Invaded;Longitudinal Studies;Lymphogranuloma Venereum;Mediating;member;Modeling;Molecular;mouse model;Mucous Membrane;Mus;mutant;obligate intracellular parasite;Outcome;pathogen;Pathogenesis;Pathology;Pathway interactions;polymerization;Polymers;protein function;Protein Truncation;Proteins;Reproducibility;reproductive tract;Research Design;respiratory pathogen;rho;Role;Source;success;Surface;Testing;Time;tissue tropism;Toxic effect;Toxin;Virulence;Work

PROJECT_TITLE: Role of putative cytotoxins in Chlamydia infection

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Disability Research;Eye Disease and Disorders of Vision;Genetics;Human Genome

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Despite eﬀorts to increase diversity and inclusion, opportunities in data-driven genomics research are still unequally oﬀered to people with visual impairments. I will identify barriers to accessing genomics data and visualization resources through comprehensive evaluations and will implement novel tools by designing accessible representations, interactions, and interfaces that will complement screen reader and magniﬁer assistive technologies. The developed tools will not only help content creators to eﬃciently and accurately create accessible visualizations but also enable current and prospective genomics students, researchers, and clinicians with visual impairments to access, interpret, and analyze genomics data.

PI_NAMEs: LYI, SEHI  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Adult;biomedical resource;Clinical;Cognitive;Complement;Data;Data Analyses;data portal;data visualization;design;digital;disability;Disabled Persons;diversity and inclusion;Education;Effectiveness;Evaluation;Friends;Funding;genome resource;genomic data;Genomics;Goals;graphical user interface;Guidelines;improved;Intuition;Journals;Metadata;Mus;National Human Genome Research Institute;natural language;Nature;novel;Online Systems;Paper;Persons;Population;Principal Investigator;prospective;Reader;Reporting;Research;Research Personnel;Resources;Scientist;Self-Help Devices;Semantics;Series;Structure;Students;Techniques;Technology;tool;United States National Institutes of Health;Vision;Visual;Visual disability;Visual impairment;Visualization;Visualization software;web page;Work

PROJECT_TITLE: Increasing Diversity of the Genomics Workforce Through Accessible Data and Visualization

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: The care and treatment of patients with Alzheimer’s disease and related dementias (ADRDs) are significant burdens to the American healthcare system. Without greater insight into the molecular causes of dementia, the development of disease-modifying treatments to halt or cure disease will remain out of reach. Lewy Body Dementia is the second most common form of neurodegenerative dementia, and the goal of this proposal is to apply new genetic information to dissect the early events that drive the mixed pathology associated with its most significant genetic risk factor and explore a potential mitigating factor.

PI_NAMEs: LAVOIE, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Address;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid pathology;amyloid precursor protein processing;amyloidogenesis;Antibodies;Attention;Autopsy;autosome;Biochemical;Biological;Biology;Brain;brain tissue;Caring;Cathepsins B;causal variant;Cells;Ceramides;Clinical;clinical diagnosis;clinical phenotype;comorbidity;Complex;Data;Defect;Dementia;dementia risk;Dementia with Lewy Bodies;Development;Disease;disease diagnosis;Enzymes;Etiology;Event;experimental study;Functional disorder;gamma secretase;Gaucher Disease;Genes;Genetic;genetic information;genetic risk factor;genome wide association study;Glucose;glucosylceramidase;glycosylation;Goals;Golgi Apparatus;Haplotypes;Healthcare Systems;Hippocampus;Human;Impairment;In Vitro;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;insight;Knock-in Mouse;late endosome;Lewy Bodies;Lewy Body Dementia;Link;loss of function;loss of function mutation;LRRK2 gene;lysosomal proteins;Lysosomes;Medical Genetics;Membrane;Metabolism;Missense Mutation;Modeling;Molecular;Morphology;mouse model;mutant;Mutation;mutation carrier;neoantigens;Nervous System Disorder;neurodegenerative dementia;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;neuropathology;nicastrin protein;novel;Parkinson Disease;Parkinson's Dementia;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Phosphotransferases;Physiological;Polysaccharides;Process;Protein Glycosylation;Proteins;Publishing;recruit;Recruitment Activity;Regulation;repaired;Reporting;Risk;Risk Factors;Role;Senile Plaques;Severities;synuclein;synucleinopathy;tau aggregation;Testing;trafficking;Work

PROJECT_TITLE: Intersection of GBA and LRRK2 in Lewy Body Dementia

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Social Determinants of Health;Substance Misuse

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: This study aims to elucidate how early social isolation alters the developmental trajectory of frontal circuits and social and cognitive behaviors implicated in substance use disorder using rat models. Such findings will inform potential developmental windows and circuit-level targets for effective early interventions when drug use is often initiated.

PI_NAMEs: FERLAND, JACQUELINE-MARIE ;HURD, YASMIN L.;MORISHITA, HIROFUMI  (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;Adult;Animals;Area;Behavior;Behavioral;Brain region;Cognitive;Complex;Control Groups;Decision Making;deep learning;Development;developmental psychobiology;developmental psychology;disorder risk;drug of abuse;Drug usage;Drug user;Early Intervention;Electrophysiology (science);experience;Exposure to;Future;Gambling;Goals;Habenula;Human;imaging study;Impulsivity;in vivo;Lateral;Life;Lifestyle-related condition;Link;Longitudinal Studies;Machine Learning;Measurement;Medial;Mediating;Mental disorders;Modeling;Motivation;multimodality;Mus;neurobehavioral;neuromechanism;Neurons;optogenetics;Play;Prefrontal Cortex;Rattus;Reciprocal Social Interaction;reduced substance use;reward processing;Risk;Rodent;Rodent Model;Role;Self Administration;Shapes;social;Social Behavior;Social Controls;social deprivation;Social Functioning;Social isolation;Structure of paraventricular nucleus of thalamus;Substance Use Disorder;Sucrose;Testing;tool;Treatment outcome;Ultrasonics;vocalization

PROJECT_TITLE: Impact of juvenile social isolation on maturation of frontal circuit and SUD-relevant behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 CEM-N (M1)]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Stroke

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Many patients with acute ischemic stroke are ineligible for currently available standard treatments (clot-busting medication or mechanical removal of clot), and many are non-responders, resulting in low rate of excellent outcomes, which necessitates development of novel therapies. We propose a new treatment in which a weak electrical current will be applied via scalp electrodes to increase collateral blood flow to the brain and rescue the brain tissue at risk of injury. In this study, we primarily aim to find an optimal dose of this therapy that is both adequately safe and effective on imaging marker of brain tissue rescue.

PI_NAMEs: BAHR HOSSEINI, MERSEDEH  (contact);FENG, WUWEI ;HILLIS, ARGYE E.

PROGRAM_OFFICER_NAME: JANIS, SCOTT

PROJECT_TERMS: Acute;Amendment;American Heart Association;Animal Model;Apoptotic;Bayesian Modeling;Biological;Biological Markers;Blood flow;Blood Vessels;Brain;brain tissue;Cause of Death;Cephalic;cerebral blood volume;Cerebral Ischemia;clinical efficacy;clinical research site;Clinical Trials;Coagulation Process;Contracts;design;Development;Devices;disability;Dose;efficacy outcomes;electric field;Electric Stimulation;Electrodes;Eligibility Determination;emergency settings;endovascular thrombectomy;Enrollment;Excision;excitotoxicity;Funding;Future;Growth;Human;hypoperfusion;Image;imaging biomarker;improved;improved outcome;individualized medicine;Infarction;Inflammatory;Injury;innovation;Institutional Review Boards;Intervention;Intracranial Hemorrhages;Intravenous;Ischemia;Ischemic Stroke;Lytic;Magnetic Resonance Imaging;Mechanics;multimodality;neuroprotection;neuroregulation;Nonlytic;novel;novel therapeutics;Oncology;Outcome;Patient-Focused Outcomes;Patients;Performance;Perfusion;Pharmaceutical Preparations;Phase;Physiological;Pilot Projects;post stroke;preclinical study;Probability;radiological imaging;Randomized;Regimen;Reperfusion Therapy;Risk;Safety;safety and feasibility;Scalp structure;Signal Transduction;Site;standard care;Stroke;stroke patient;stroke therapy;Subgroup;Techniques;Testing;therapy development;Tissues;Training;transcranial direct current stimulation;Vasodilation

PROJECT_TITLE: Transcranial Electrical Stimulation in Stroke EaRly After onset Clinical Trial-2 (TESSERACT 2)

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-G (65)]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Microbiome;Nutrition;Pediatric;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE The challenging eating behaviors of children with autism spectrum disorder (ASD) are highly prevalent and are associated with serious negative health consequences. Parents face challenges with these behaviors which results in parent anxiety and family burden. This study will use novel methods, during mealtime in the child's home, to understand multiple factors that may be contributing to these behaviors, so that we can begin to develop treatment approaches to improve the health and well-being of children with ASD and their families.

PI_NAMEs: WALLISCH, ANNA  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 6 year old;Address;Adult;Affect;Anxiety;Area;Arousal;autism spectrum disorder;autism symptoms;autistic;autistic children;Behavior;behavior prediction;Behavioral;biobehavior;Biological;Biological Markers;biopsychosocial;Biosensor;Buffers;Cellular Phone;Child;Child Rearing;Child Support;Child Welfare;Childhood;Clinical;Code;Cues;Data;Dependence;Development;Diet;Dietary intake;Eating;Eating Behavior;Ecological momentary assessment;Environmental Risk Factor;ethnic minority;Exclusion;Exhibits;Face;Family;family burden;feeding;Food;Future;gastrointestinal;gastrointestinal symptom;Goals;gut-brain axis;Health;Heterogeneity;Home;improved;In Situ;Individual;individual variation;Intellectual functioning disability;interest;Intervention;Knowledge;Knowledge acquisition;Link;Malnutrition;Mediating;Mentorship;Methodology;Methods;microbiome;novel;Obesity;obesity in children;Parent-Child Relations;parental influence;Parents;Patient Self-Report;Pattern;personalized intervention;personalized medicine;Phenotype;Physiological;Physiology;Population;potential biomarker;Predictive Factor;psychologic;racial minority;recidivism;Reporting;Research;response;Risk;skill acquisition;social factors;standard of care;Stress;stressor;Time;Training;treatment response;Underrepresented Populations

PROJECT_TITLE: Examining Mechanisms of Challenging Eating Behaviors in Children with Autism Using a Biopsychosocial Approach.

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Mental Health;Mental Illness;Patient Safety;Psychosis;Schizophrenia;Serious Mental Illness;Telehealth

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Behavioral economic and financial incentive-based are promising means to sustain gains from Coordinated Specialty Care (CSC) after patients leave this short-term treatment. However, they face two obstacles in this setting: (1) frequent loss of contact in care transition and (2) concerns about the ethical acceptability of these interventions. This K23 will design and test these interventions in the post-CSC period while leveraging (1) text messaging and emerging mHealth apps to increase continued contact as patients leave CSC and (2) participatory, ethically informed research design to ensure that there is high acceptability of the interventions.

PI_NAMEs: SMITH, WILLIAM RUDOLPH (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Appointment;behavior change;Behavioral;behavioral economics;care outcomes;career;Caring;Clinic;Clinical;community based participatory research;Coordinated Specialty Care;cost;cost effective;Data;design;Drug Screening;economic incentive;Education;Effectiveness;effectiveness measure;effectiveness testing;Employment;Ethics;experience;Face;Family;Family member;financial incentive;first episode psychosis;Funding;Goals;Health;Health behavior;implementation barriers;improved;incentive strategies;incentive-based intervention;Intervention;Interview;Measurement;Measures;Mediator;medication compliance;Medication Management;Methods;mHealth;Mobile Health Application;Monitor;mortality;multidisciplinary;Outcome;Patient Compliance;Patients;Persons;pill;Positioning Attribute;Preparation;Psychoses;Psychotherapy;Quality of life;Questionnaires;Randomized, Controlled Trials;recruit;reinforced behavior;Reporting;Request for Applications;Research;Research Design;Research Personnel;retention rate;Science;Scientist;Services;stakeholder perspectives;Structure;substance use;success;Surveys;Testing;Text Messaging;Time;Training;treatment planning;Use Effectiveness;Work

PROJECT_TITLE: Behavioral Economics and Financial Incentive-Based Strategies to Optimize Post-CSC Outcomes

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: COLUMBIA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: OVERALL: PROJECT NARRATIVE The Center for Clinical & Translational Research at the University of South Carolina (CLINTRUSC) draws on the many strengths that exist in the Schools and Colleges of the University of South Carolina (USC) to create a Clinical & Translational Research Center that will address a long-standing deficiency in meaningful disparities- focused, clinic-based research. The CLINTRUSC will provide, for the first time at USC, a cohesive infrastructure to quickly deploy clinical/translational research projects within the Midlands regions of South Carolina to 1) Develop a Cohesive Clinical and Translational Research Hub at USC and in the Midlands and 2) Integrate and Coordinate this Hub with Existing Health Systems and Partners. Using existing infrastructure and creating new Advisory Boards, Committees, and Core resources to support Pilot and Developmental Projects and the professional development of individuals dedicated to addressing health disparities CLINTRUSC will work in the spirit of community-based participatory research (CBPR) to advance public health and improve clinical outcomes in a region badly in need of this resource.

PI_NAMEs: HEBERT, JAMES R;SPINALE, FRANCIS G (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Address;African American;African American population;Age;behavior test;Cardiovascular Diseases;Center for Translational Science Activities;Chronic;Chronic Disease;Clinic;Clinical;Clinical and Translational Science Awards;clinical center;Clinical Research;clinical research site;Clinical Trials;college;Communities;community based participatory research;community engagement;Community Outreach;County;data management;Dedications;Development;Diagnosis;Dietary Intervention;Discipline of Nursing;Disease;Disparity;Epidemiologist;evidence base;experience;Foundations;Frequencies;Geography;Goals;Health;health disparity;Health Personnel;health science research;Health Sciences;Health system;Healthcare Systems;high risk;high risk population;Hispanic;improved;Incidence;Individual;Infrastructure;Malignant Neoplasms;Medical;medical schools;Medicine;Metabolic Diseases;Neurodegenerative Disorders;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Observational Study;Outcome;outreach clinics;Parents;participant enrollment;patient population;Patients;Penetrance;Pharmacy Schools;Population;Positioning Attribute;Prevention;primary care clinic;prisma;Program Development;programs;Public Health;Public Health Schools;Qualifying;Research;research and development;Research Design;Research Project Grants;Resistance;Resources;Risk Factors;Rural;rural area;Rural Community;Schools;Scientist;Services;Social Work;South Carolina;Structure;synergism;Time;Translational Research;underserved area;underserved community;United States Department of Veterans Affairs;Universities;Vertebral column;Veterans;Veterans Health Administration;Virulence;Work

PROJECT_TITLE: The Center for Clinical and Translational Research at the University of South Carolina (CLINTRUSC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (CD)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Rural Health;Social Determinants of Health

PI_NAMEs: SPINALE, FRANCIS G (contact)

PROJECT_TERMS: Address;African American population;Ambulatory Care Facilities;Area;Budgets;Cardiovascular Diseases;Catchment Area;Centers of Research Excellence;Clinic;Clinical;clinical center;Clinical Research;clinical research site;Clinical Trials;Collaborations;college;Communicable Diseases;Communities;community advisory board;community based participatory approach;community based participatory research;community engagement;community organizations;Community Outreach;Community Trial;data management;Dedications;design;Development;disability;Discipline of Nursing;Disease;Disparity;dissemination science;Ensure;Evaluation;experience;Federally Qualified Health Center;Funding;Goals;Health;health disparity;Health Personnel;Health Professional;Health Sciences;Health system;Healthcare Systems;high risk;high risk population;implementation science;improved;Incidence;Individual;Infrastructure;innovation;Intervention;Malignant Neoplasms;marginalization;Medical Research;medical schools;medically underserved;Mission;modifiable risk;Monitor;Neurodegenerative Disorders;Non-Insulin-Dependent Diabetes Mellitus;organizational structure;Performance;Persons;perspective taking;Pharmacy facility;Physicians;Pilot Projects;Population;preventable death;Primary Health Care;prisma;Productivity;programs;Public Health;Public Health Schools;Reporting;Research;Research Design;Resources;Risk Factors;Role;Rural;Scientist;Severities;socioeconomics;South Carolina;Structure;success;Training;Translating;Translational Research;translational research program;Underrepresented Minority;Underserved Population;United States Public Health Service;Universities;Vertebral column;Work

PROJECT_TITLE: CLINTRUSC Admin Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: HOFSETH, LORNE J (contact)

PROJECT_TERMS: Address;Administrative Supplement;Affinity;Applications Grants;aspirate;Award;Basic Science;Clinical;clinical center;Clinical Research;Clinical Sciences;cohort;Collaborations;Communities;community based participatory research;computerized data processing;Data Analyses;data curation;data management;Dedications;design;Development;Education;Educational workshop;empowerment;Enrollment;Ensure;Equipment;Fortification;Fostering;Funding;Funding Agency;Funding Opportunities;Future;Goals;Grant;Growth;Health;Housing;Individual;Institutional Review Boards;interdisciplinary collaboration;leadership development;meetings;member;Mentors;Mentorship;Mission;Monitor;novel;Periodicals;Play;Program Development;programs;Progress Reports;Reporting;Research;research and development;Research Design;research faculty;Research Personnel;Resources;Role;Rotation;Series;Services;skill acquisition;skills;skills training;South Carolina;Structure;success;Techniques;Training;Translational Research;translational study;Universities;Writing

PROJECT_TITLE: CLINTRUSC_PD Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Rural Health;Social Determinants of Health

PI_NAMEs: ALBRECHT, HELMUT  (contact)

PROJECT_TERMS: Address;Affect;Area;Arts;Black Populations;Catchment Area;Categories;Charge;Chronic Disease;Clinic;Clinical;clinical center;clinical practice;Clinical Research;clinical research site;clinical translation;college;Communities;community advisory board;community based research;community engagement;Community Outreach;Death Rate;Discipline of Nursing;Education;Ensure;Federally Qualified Health Center;Frequencies;Goals;Health;health care delivery;health disparity;Healthcare;Healthcare Systems;HIV;hospitalization rates;Hospitals;Individual;Infrastructure;Institution;interest;Leadership;Link;Maps;Medical;medical schools;Medicine;Morbidity - disease rate;Outcome;Outpatients;outreach;patient population;Patient Recruitments;Patients;Pharmacy facility;Phase;Policies;Positioning Attribute;primary care clinic;Primary Health Care;prisma;Procedures;programs;Public Health;Research Activity;Rural;rural area;Rural Community;rural health clinic;Science;Site;Social Work;South Carolina;success;System;Time;Translational Research;Trust;Underrepresented Populations;underserved area;United States Department of Veterans Affairs;Universities;Veterans;Work

PROJECT_TITLE: CLINTRUSC Community Engagement & Outreach Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Networking and Information Technology R&D (NITRD)

PI_NAMEs: ZHANG, JIAJIA  (contact)

PROJECT_TERMS: Acceleration;Address;Applications Grants;Artificial Intelligence;Awareness;Biometry;Charge;Clinic;Clinical;clinical center;Clinical Medicine;Clinical Research;clinical translation;Clinical Trials;cloud platform;Collaborations;Communities;community engagement;Community Outreach;computing resources;Consultations;cyber security;Data;data acquisition;Data Analyses;data management;Data Science;Data Security;Data Storage and Retrieval;design;Development;Educational workshop;Electronic Health Record;Electronics;Ensure;Environment;evidence base;experience;Faculty;Funding;Future;Goals;Health;health care delivery;Healthcare;Human Subject Research;improved;Individual;Infrastructure;innovation;Laboratory Research;Manuscripts;Measures;Medical;Medical Research;Medicine;Mentors;Methodology;Modernization;Observational Study;Outcome;Patient-Focused Outcomes;Patients;Population;population health;Procedures;Prospective Studies;Protocols documentation;Public Health;Public Health Practice;Qualifying;Reporting;Reproducibility;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;research study;Research Support;Risk Assessment;Safety;Sample Size;Science;Shapes;South Carolina;Training;Training and Education;translational pipeline;Translational Research;translational scientist;Translations;Universities;Work;Workforce Development

PROJECT_TITLE: CLINTRUSC Research Design Core (RDCD)


PI_NAMEs: BONILHA, LEONARDO F (contact)

PROJECT_TERMS: Adherence;Advisory Committees;Affect;Area;Award;base;Basic Science;career;Clinical;clinical center;clinical development;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;community engagement;Community Outreach;Data;data management;Development;Discipline;Disease;Disparity;Ensure;Ethics;Evaluation;experience;Extramural Activities;Fostering;Funding;Funding Mechanisms;Generations;Goals;Grant;Growth;Health;health goals;Health Priorities;Healthcare Systems;high standard;Historically Black Colleges and Universities;IACUC;Infrastructure;innovation;Institution;Institutional Review Boards;K-Series Research Career Programs;Knowledge;Mentors;Monitor;operation;Participant;Pilot Projects;Population;Positioning Attribute;pre-clinical;Procedures;Process;programs;Progress Reports;Records;recruit;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Role;Safety;Science;Scientist;South Carolina;Special Population;statistics;success;Testing;Training;Translational Research;translational scientist;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: CLINTRUSC Health Research Core (HR)


NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Emergency Care;Harm Reduction for Substance Misuse;Health Services;Opioid Misuse and Addiction;Opioids;Pain Research;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation;Substance Misuse;Substance Misuse Prevention

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE The U.S. opioid overdose crisis continues to escalate with over 80,000 Americans dying from an opioid overdose in 2021 alone. There is a critical public health need to develop effective interventions to prevent and treat opioid use disorder and ensure that evidence-based interventions actually reach and benefit patients, and in an equitable manner. This K02 Independent Scientist Award will provide the PI with protected time from clinical duties in support of an intensive period of research career enhancement to acquire additional skills, training, and experience in implementation science approaches to address primary prevention and treatment of opioid use disorder from the emergency department.

PI_NAMEs: KIM, HOWARD S (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Acceleration;Accident and Emergency department;Acute;addiction;Address;Administrator;Adopted;Adoption;Affect;American;career;Career Mobility;Caring;Cessation of life;Chronic;chronic pain;Clinical;clinical research site;Clinical Trials;Clinical Trials Design;Communities;Cost Analysis;Data;design;Development;dissemination science;effective intervention;effectiveness trial;effectiveness/implementation trial;Emergency Care;Emergency department visit;Emergency medical service;Emergency Medicine;Ensure;Equity;evidence base;Evidence based intervention;Evidence based treatment;experience;Exposure to;Fostering;Funding;Future;General Population;Goals;Guidelines;Harm Reduction;Health Services;Health Services Research;Health system;Healthcare Systems;Hybrids;implementation context;implementation cost;implementation design;implementation determinants;implementation evaluation;implementation outcomes;implementation science;implementation strategy;Independent Scientist Award;Intervention;Investments;Knowledge;Leadership;Literature;Low Back Pain;Measurable;Medicine;Mentored Clinical Scientist Development Program;Mentorship;Methods;Modality;Modeling;Multiple Partners;Naloxone;naloxone dispensing;National Institute of Drug Abuse;non-opioid analgesic;novel;Opioid;opioid overdose;opioid use;opioid use disorder;opioid user;Outcome;Outcomes Research;Outpatients;overdose death;overdose prevention;Pain;Patients;Persons;Physical therapy;Physicians;Play;Preparation;prescription opioid;prevent;Prevention;Prevention strategy;Primary Prevention;programs;Public Health;Quantitative Evaluations;randomized trial;Recommendation;Recovery Support;Research;Research Activity;Research Personnel;Research Training;Role;Scientist;Site;skills;Symptoms;Therapeutic Intervention;therapy development;Time;Trainers Training;Training;Training Activity;Translations;United States National Institutes of Health;Work

PROJECT_TITLE: Research Career Enhancement in Implementation Science to Address Primary Prevention, Harm Reduction, and Evidence-Based Interventions for Opioid Use Disorder from the Emergency Department

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Health Services;Physical Injury - Accidents and Adverse Effects

ORG_CITY: BALTIMORE

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE The overarching objective of this K24 Renewal proposal is to leverage the increased protected research time afforded by the K24 award to ensure intensive mentorship of promising surgeon-scientists, sustain ongoing mentorship of surgeons within my clinical trials network, allow the completion of comparative effectiveness exploratory analyses, and develop a clinical trial master protocol. This proposal aims to strengthen my mentorship capabilities and generate novel avenues for my mentees to succeed in bolstering their independent research careers. Specifically, mentees will 1) explore clinically important research questions using high-quality data from the PREP-IT trials; 2) have immediate access to an established trial infrastructure for new ideas supported by a master protocol; and 3) develop original research ideas to be continued in their independent research careers.

PI_NAMEs: SLOBOGEAN, GERARD  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Agreement;Antibiotics;Area;Award;Bathing;care outcomes;career;career development;Caring;Chlorhexidine;Clinical;clinical practice;Clinical Trials;Clinical Trials Network;comparative effectiveness;comparative effectiveness study;Data;Data Analyses;Data Set;Databases;Dedications;design;Development;disability burden;Disparity;Effectiveness;Effectiveness of Interventions;empowerment;Ensure;experience;Face;flexibility;follow-up;Foundations;Fracture;Fracture Fixation;fragility fracture;Funding;Generations;Goals;graduate student;Grant;Growth;Hospitals;Hour;improved;improved outcome;Infrastructure;innovation;Institutional Review Boards;Intervention;Investments;Journals;Lead;Manuscripts;Medical Students;Medicine;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);Multi-Institutional Clinical Trial;Musculoskeletal;musculoskeletal injury;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;New England;next generation;novel;Open Fractures;Operative Surgical Procedures;Orthopedic Surgery;Orthopedics;Outcome;Outcomes Research;participant enrollment;Patient Care;patient oriented research;Patient-Focused Outcomes;Patients;Pelvis;Postoperative Period;primary outcome;Process;programs;Protocols documentation;Publications;Publishing;recruit;Research;Research Design;Research Methodology;Research Proposals;Research Training;response;Sample Size;Scientist;Services;soft tissue;Standardization;success;Surgeon;surgical research;Surgical Wound Infection;Techniques;tibia;Time;Training;Trauma;United States National Institutes of Health;Variant;wound

PROJECT_TITLE: Continuing the development of orthopaedic surgeon-scientist expertise in patient-oriented research

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 SP (M1)]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Biotechnology;Cardiovascular;Clinical Research;Heart Disease;Lung;Prevention;Pulmonary Hypertension

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Heart failure (HF) without gross weakening of the heart pump (HF with preserved ejection fraction; HFpEF) disproportionately burdens older adults and has no effective therapy, and risk is particularly high when pulmonary vascular pressure is elevated. This project will use novel image processing approaches to measure anatomic remodeling of the pulmonary vasculature and determine its association with risk of developing HFpEF. Establishing pulmonary vascular remodeling, measurable on a routinely performed non-invasive imaging test (non-contrast chest CT), as a novel HFpEF risk factor will enable innovative strategies to prevent the morbidity, mortality, and cost associated with HF.

PI_NAMEs: SAN JOSE ESTEPAR, RAUL ;SHAH, AMIL M (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;adverse outcome;Affect;Age;age related;Anatomy;aptamer;arterial remodeling;Atherosclerosis Risk in Communities;biracial;Blood Vessels;Blood Volume;Cardiac;Cardiopulmonary;Cardiovascular system;Chest;Clinical;Clinical assessments;cohort;Communities;Complex;cost;Data;defined contribution;Development;Echocardiography;effective therapy;efficacious treatment;EFRAC;Elderly;Fibrosis;fibrotic lung;Framingham Heart Study;functional decline;Functional disorder;Funding;genomic data;Genomics;Goals;Heart;Heart Atrium;Heart failure;hemodynamics;Image;image processing;Individual;Inflammatory;Injury;innovation;Knowledge;late life;Left;Left Ventricular Dysfunction;Left Ventricular Ejection Fraction;Lung;lung injury;lung pressure;Measurable;Measures;Mendelian randomization;Molecular;Morbidity - disease rate;Morphology;mortality;National Heart, Lung, and Blood Institute;new therapeutic target;non-invasive imaging;novel;older adult;Outcome;Participant;Pathway interactions;Patients;Phenotype;preservation;pressure;prevent;Proteins;Proteomics;Publishing;Pulmonary Emphysema;Pulmonary Hypertension;pulmonary vascular disorder;pulmonary vascular remodeling;Pump;Resistance;Risk;Risk Factors;Role;Scanning;Signal Pathway;Smoker;Spirometry;Structure;System;systemic inflammatory response;Techniques;Testing;Therapeutic;therapeutic target;Transforming Growth Factor beta;Validation;Venous;Visit;Walking;X-Ray Computed Tomography

PROJECT_TITLE: Contributions of pulmonary arterial and venous remodeling to HFpEF in the elderly

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Headaches;Neurosciences;Opioids;Pain Research;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Chronic pain after traumatic brain injury (TBI) exerts a steep toll on Veterans and civilians alike, and one of the major obstacles to developing effective therapies for these patients is a critical knowledge gap in understanding the underlying pathophysiology of TBI-related pain. Emerging data have suggested that dysfunction of the brainstem pain regulatory system in the rostral ventromedial medulla (RVM) is involved in chronic pain after TBI. This project aims to elucidate the mechanisms underlying the plasticity of the brainstem RVM pain-facilitating circuit following TBI, and how this circuit contributes to chronic pain.

PI_NAMEs: CHEN, QILIANG  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Acute;Acute Pain;Address;Affect;allodynia;Anatomy;Anesthesiology;Animal Genetics;Animals;antagonist;Attenuated;Behavioral;behavioral sensitization;Brain;Brain Concussion;Brain Injuries;Brain Stem;Calcium;career development;Cells;central pain;central sensitization;Characteristics;chronic pain;chronic painful condition;clinical practice;comparison control;conditioned place preference;Data;Development;disability risk;Distal;dorsal horn;effective therapy;Electrophysiology (science);experience;Exposure to;Feedback;Fiber;Foundations;Functional disorder;Funding;Future;Gene Delivery;Genetic;Goals;Headache;high risk;Hyperalgesia;Hypersensitivity;in vivo;Individual;insight;Knowledge;Label;Lesion;Light;Limb structure;Link;Long term disability;Masks;Mechanics;Mediating;Medicine;Mentors;Mentorship;Migraine;mild traumatic brain injury;Modeling;mouse model;mu opioid receptors;Mus;Naloxone;neural circuit;neural network;Neurons;neurophysiology;Neurosciences;Neurosciences Research;neurotoxic;Nociception;Operative Surgical Procedures;Opioid;Opioid Antagonist;opioid misuse;Opioid Receptor;Output;Pain;pain behavior;Pain management;Pain Research;patch clamp;Patients;Persistent pain;Photometry;Physicians;Physiology;Play;Postoperative Pain;pre-clinical;Prevalence;prevent;Research Personnel;Resources;response;Role;Scientist;selective expression;sensor;Signal Transduction;Slice;Spinal;Stimulus;Stress;Surgical incisions;Synapses;System;Testing;tool;Training;Transfection;Transgenic Animals;transmission process;Traumatic Brain Injury;Trigeminal System;Vertebral column;Veterans;Whole-Cell Recordings;Withdrawal;Work

PROJECT_TITLE: The Role of Pain-Facilitating Circuits in Chronic Pain after Traumatic Brain Injury

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]