NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Radiation Oncology;Rare Diseases;Women's Health Research

ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY COLLEGE LONDON

ORG_ZIPCODE: WC1E 6BT

PHR: PROJECT NARRATIVE The project is relevant to public health as it seeks to enhance the effectiveness and affordability of radiotherapy treatment in lower income settings. It is expected to improve both the health status and quality of life of men and women suffering from two major high burden cancers: cervical and head and neck cancers.

PI_NAMEs: AGGARWAL, AJAY  (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Address;Anatomy;anti-cancer research;Area;Artificial Intelligence;Automation;Breast;burden of illness;Cancer Burden;Cancer Center;Cancer Hospital;Cancer Patient;cancer therapy;cancer type;Cervical;Clinical;Computer software;cost;Cost Savings;Country;curative treatments;design;Disease;economic impact;Effectiveness;Ensure;European;Future;Head and Neck Cancer;Health Status;Human Resources;Improve Access;improved;Incidence;Income;India;International;Jordan;low and middle-income countries;Low income;low income country;Lung;Malaysia;Malignant neoplasm of cervix uteri;Malignant neoplasm of esophagus;Malignant Neoplasms;Manuals;Medical;meetings;men;Modality;Modeling;mortality;Multicenter Studies;Oncologist;Organ;Outcome Measure;palliation;Pathway interactions;Patient Participation;Patients;Positioning Attribute;Process;prospective;Prospective Studies;Protocols documentation;Public Health;Public Sector;Quality of life;Radiation;Radiation induced damage;Radiation Oncology;radiation risk;Radiation therapy;Resources;Risk;Sample Size;secondary outcome;Shapes;Societies;South Africa;Specialist;State Hospitals;Surveys;Time;time use;treatment optimization;treatment planning;tumor;web services;Woman;X-Ray Computed Tomography

PROJECT_TITLE: ARCHERY: Artificial Intelligence based Radiotherapy treatment planning for Cervical and Head and Neck cancer


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Climate-Related Exposures and Conditions;Genetics;Neurosciences

ORG_CITY: Chicago

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE Increasing the diversity of the model systems we study will proportionally increase our understanding of how sensory systems evolve, reveal conserved principles of sensory processing, and ultimately help us better extrapolate results we obtain in animal studies to the human nervous system, in both normal and disease states. Here, we propose to expand our understanding of the organization of temperature and humidity sensing circuits by introducing the desert fly Drosophila mojavensis (adapted to dry and heat conditions) as a new model alongside the common laboratory fruit fly Drosophila melanogaster. This comparative work will lead to a greater understanding of the conserved principles behind somatosensory processing and behavior, and in the long term help enhance our understanding of temperature and pain sensation in both animals and humans.

PI_NAMEs: CAPEK, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Air;Animal Model;Animals;Behavior;Biological Assay;Biological Models;Brain;Cactaceae;Caenorhabditis elegans;calcium indicator;cell type;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;CRISPR/Cas technology;Dangerousness;design;Disease;Drosophila genus;Drosophila melanogaster;Dryness;egg;Environment;extreme heat;extreme temperature;flexibility;fly;Funding;Gene Transfer Techniques;Genes;Genetic;genetic manipulation;genome editing;Goals;Human;Humidity;Image;insight;Invertebrates;Juice;Knock-out;Laboratories;Love;Mediating;Mexico;Modality;model organism;Modeling;Molecular;Mus;mutant;Nervous System;neural circuit;Neurobiology;neurogenetics;Neurons;Neurosciences;optogenetics;pain sensation;preference;pressure;promoter;Protocols documentation;Reagent;receptor;Receptor Gene;response;sensor;Sensory;sensory system;Shapes;somatosensory;Southwestern United States;Techniques;Technology;Temperature;Temperature Sense;Transgenes;Transgenic Organisms;Work

PROJECT_TITLE: Comparative Approaches for the Study of Somatosensory Processing in Drosophila


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: PHILADELPHIA

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: 8. Project Narrative In the United States, there are approximately 2,500-3,000 new cases per year and approximately 28,000 people living with cutaneous T-cell lymphoma (CTCL), a relatively rare form of Non-Hodgkin's Lymphoma (NHL), and there is currently no FDA approved cure or first line treatment for CTCL. SGX301 (0.25% hypericin), a novel, first-in-class photodynamic therapy utilizing safe visible light for activation has received Orphan Product and Fast Track designation from the FDA and has recently shown efficacy in the study's primary and key secondary endpoints of a Phase 3 pivotal study. The primary objective of this proposal is to advance the clinical evaluation of SGX301 by conducting the clinical study RW-HPN-MF-01, “Assessment of Treatment with Visible Light Activated Synthetic Hypericin Ointment in Mycosis Fungoides (MF) Patients”, evaluating extended administration of SGX301 as a photodynamic therapy (PDT) for MF/CTCL.

PI_NAMEs: KIM, ELLEN J (contact)

PROGRAM_OFFICER_NAME: KAPOOR, SHELLY

PROJECT_TITLE: Assessment of Treatment with Visible Light Activated Synthetic Hypericin ointment in Mycosis Fungoides Patients.


ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative: Children and young adults with high-grade brain/spine tumors have limited treatment options and a dismal prognosis, underscoring the urgent need to develop novel therapies for this vulnerable patient population. The proposed clinical trial will assess the safety and effectiveness of 177Lu-DOTATATE, a targeted radiotherapy that binds to tumor cells that express somatostatin receptors, causing tumor cell death through localized release of radiation. If 177Lu-DOTATATE proves safe and effective in treating children and young adults with refractory brain/spine tumors that express somatostatin receptors, further studies will be planned to expand to a larger patient population and eventually incorporate 177Lu-DOTATATE into upfront treatment backbones for these aggressive diseases.

PI_NAMEs: LAZOW, MARGOT  (contact);SALLOUM, RALPH

PROGRAM_OFFICER_NAME: KARP, JACQUELINE

PROJECT_TITLE: Phase I/II Study of 177Lu-DOTATATE in Children and Young Adults with Recurrent/Progressive High-Grade CNS Tumors and Meningiomas which Express Somatostatin Type 2A Receptors [9/24/21 IND]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: The Chronic Effects of Neurotrauma Warfighter Epidemiology Cohort was developed to identify phenotypes of comorbidity among deployed Post-9/11 Veterans in order to compare emergence of neurosensory, neurodegenerative, pain, and mental health comorbidity in Veterans TBI. We will extend the Warfighter Epidemiology Cohort by 1) including deployed and non-deployed Veterans, 2) adding new data sources, and 3) extending the science of longitudinal analyses of outcomes associated with TBI. We will identify mTBI phenotypes using VA/DoD data, identify prevalence of key comorbidities neurodegenerative disease, SUD, psychological comorbidities, and self-harm behaviors before and after mTBI exposure, and use deep learning models to develop risk scores for key comorbidities and identify optimal processes of care for mTBI. These analyses will illuminate specific target areas to improve the quality of TBI care.

PI_NAMEs: PUGH, MARY JO  (contact)

PROJECT_TERMS: Acute;Algorithms;Area;Behavior;blast exposure;Brain Injuries;Caring;Categories;Characteristics;Chronic;Chronic Care;cohort;comorbidity;Data;data registry;Data Sources;deep learning;deep learning model;economic outcome;Epidemiology;Functional disorder;health data;improved;Individual;Injury;Inpatients;interest;Learning;longitudinal analysis;Mental Health;Methods;mild traumatic brain injury;military health system;Military Personnel;Modeling;Nerve Degeneration;Nervous System Trauma;Neurodegenerative Disorders;Neurosecretory Systems;neurosensory;Outcome;Outpatients;Pain;Pathway interactions;Pharmacy facility;Phenotype;post 9/11;Prevalence;Process;psychologic;Psychological reinforcement;Risk;Science;screening;Self-Injurious Behavior;Severities;Sleep;Source;Substance Use Disorder;Support System;Text;Trauma;Veterans;warfighter;Work

PROJECT_TITLE: VA-DoD Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC): Phenotypes of Persistent Comorbidity in Postâ9/11 Era Veterans with mTBI

STUDY_SECTION: RRDB

STUDY_SECTION_NAME: Brain Injury[RRDB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Mental Health;Nutrition;Obesity;Prevention

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: This study aims to perform a two-stage randomized double-blind placebo-controlled study to test the effectiveness of behavioral weight loss and pharmacologic treatment with a recently FDA-approved weight-loss medication (naltrexone/bupropion), alone and in combination, for the treatment of loss-of-control (LOC) eating following bariatric surgery. This study will produce important new information about the relative efficacy of behavioral and pharmacologic treatments following bariatric surgery, will produce important novel information regarding whether to continue weight-loss medication to improve longer-term outcomes amongst those who respond to initial treatments, and whether an alternative (distinct) medication enhances outcomes amongst those who do not respond to the initial treatments.

PI_NAMEs: GRILO, CARLOS M (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Acute;Adult;Aftercare;bariatric surgery;Behavior Therapy;Behavioral;Binge Eating;Binge eating disorder;Blinded;Body Weight decreased;Bupropion;Clinical;clinical care;comorbidity;Data;design;Double-Blind Method;Eating Behavior;Eating Disorders;effective therapy;Effectiveness;effectiveness evaluation;effectiveness testing;FDA approved;Heterogeneity;high risk;improved;Intervention;Literature;loss of control over eating;Maintenance;Medical;Metabolic;Modeling;Morbid Obesity;Naltrexone;novel;obese patients;Obesity;Operative Surgical Procedures;Outcome;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;placebo controlled study;Placebos;prognostic significance;prospective;psychosocial;Randomized;Randomized, Controlled Trials;Research;response;Subgroup;surgery outcome;Testing;Treatment Effectiveness;Vyvanse;Weight

PROJECT_TITLE: Using a SMART Design to Examine Pharmacological and Behavioral Treatments to Treat Loss-of-Control Eating and Improve Weight Outcomes after Metabolic and Bariatric Surgery

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Substance Misuse

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: Lay Abstract The number of African Americans, Hispanic Americans, American Indians, and Pacific Islanders who do drug addiction research is much lower than would be expected based on their representation in the U.S. population. We will establish a national Center for Underrepresented Research in Addiction (CURA) program that will promote the advancement of these underrepresented minorities who are junior faculty members in academia. The program will involve a series of workshops and mentoring over several years with instruction and mentoring in drug addiction research, professional development, and ethics provided by a large number of nationally recognized faculty members.

PI_NAMEs: TORRES, GONZALO E. (contact)

PROGRAM_OFFICER_NAME: HOLMES, ANGELA L

PROJECT_TERMS: Academia;addiction;Address;African American;African American population;American Indians;Applications Grants;Area;career;career development;Career Mobility;career networking;college;Communication;Data;demographics;design;Development;Development Plans;Disabled Persons;Discipline;Disparity;Drug Addiction;early-career faculty;Education;Educational process of instructing;Educational workshop;Elements;Ethics;Evaluation;experience;Exposure to;Faculty;Funding;Goals;Grant;Hispanic;Hispanic Americans;implicit bias;Individual;Individualized education program;Institution;Instruction;Interview;Journals;Letters;Manuscripts;Measures;meetings;member;Mentors;Modeling;Monitor;Native Americans;Nature;Neurosciences;Oral;Pacific Islander;Participant;Pathway interactions;patient engagement;peer coaching;Population;Positioning Attribute;Postdoctoral Fellow;Process;Program Development;programs;Publications;Publishing;Recommendation;recruit;Research;Research Project Grants;responsible research conduct;Self Assessment;senior faculty;Series;skills;success;symposium;Testing;Training;Training Programs;Underrepresented Minority;Underserved Population;United States;Universities;Visit;Work;Writing


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Strategies that shift attention to the future may improve health decision-making, and one such strategy, Episodic Future Thinking (EFT), has been shown to improve food choices and reduce intake, but it remains unclear whether and how this strategy may impact weight loss. This randomized controlled trial will compare three Internet-delivered behavioral weight loss (iBWL) programs to test whether adding prevention-, or promotion-focused EFT-based strategies to a standard iBWL may improve weight loss and related outcomes. Further, it may determine for whom each approach is best in order to optimize weight loss in individuals with overweight/obesity.

PI_NAMEs: DEMOS, KATHRYN E (contact)

PROJECT_TERMS: Adherence;adverse outcome;Aftercare;Age;Attention;Behavior;Behavioral;behavioral economics;Body Image;Body Weight Changes;Body Weight decreased;Characteristics;Cognitive;Coupled;craving;Data;Decision Making;demographics;Diet;discount;discounting;Exercise;Exhibits;experience;Feedback;Female;follow-up;Food;Functional Magnetic Resonance Imaging;Future;Gender;Goals;Health;Health behavior;imaging study;improved;Individual;Individual Differences;individualized medicine;insight;Intake;internet delivery;intervention effect;Literature;male;Measurement;Measures;Mediating;Mental Depression;Modeling;Morbidity - disease rate;mortality;motivated behavior;neuroregulation;novel;novel strategies;Obesity;obesity treatment;Outcome;Overweight;Participant;Pattern;personalized medicine;Physical activity;pilot trial;pleasure;Predictive Factor;prevent;Prevention;primary outcome;Process;programs;Public Health;Randomized;Randomized, Controlled Trials;Research;response;Rewards;satisfaction;Self-control as a personality trait;standard care;success;Testing;theories;Thinking;Training;Training Programs;Treatment Protocols;treatment response;treatment strategy;United States;Weight;weight loss intervention;weight loss program;Weight maintenance regimen;Work

PROJECT_TITLE: Adapting Episodic Future Thinking for Behavioral Weight Loss: Comparing Strategies and Characterizing Treatment Response

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: CAMBRIDGE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Narrative: Glucose balance is vital for life, and the molecular mechanisms that control glucose production are not completely defined. The development of therapeutics for diabetes requires an in-depth understanding of molecular regulators of glucose metabolism. This project has the potential to define a new pathway in glucose metabolism.

PI_NAMEs: DAGDEVIREN, SEZIN  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Adaptor Signaling Protein;Age;Arrestins;beta-arrestin;Binding;blood glucose regulation;Body Weight;Collaborations;Data;Defect;Diabetes Mellitus;Endocytosis;Equilibrium;experimental study;Family;Family member;Fasting;Feedback;feeding;Fellowship;Fructose;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic;Glucagon;Glucagon Receptor;Glucose;glucose metabolism;glucose production;glucose tolerance;glucose uptake;Goals;Hepatic;hepatic gluconeogenesis;Homologous Gene;Hormonal;human male;Impairment;In Vitro;in vivo;Injections;Insulin;Investigation;Knockout Mice;Laboratories;Life;Link;Lipids;Liver;LoxP-flanked allele;Mammals;Mediating;Mediator;member;Membrane;Membrane Proteins;Metabolic;metabolic phenotype;Metabolism;Modeling;Molecular;mouse model;Mouse Protein;Mus;Obesity;Pathway interactions;Postdoctoral Fellow;Protein Family;Proteins;Pyruvate;receptor;receptor internalization;Regulation;Regulatory Pathway;Reporting;Research;Resistance;response;Role;Series;Signal Pathway;Signal Transduction;Testing;therapeutic development;Tissues;trafficking;TXNIP gene;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Visual

PROJECT_TITLE: Effect of Arestin Domain-Containing 4 Protein on Glucose Metabolism


ORG_CITY: COLUMBIA

ORG_NAME: HARRY S. TRUMAN MEMORIAL VA HOSPITAL

ORG_STATE: MO

PHR: This study will utilize mouse models and patient biopsies to assess significance of Sprouty2 gene in colorectal cancer (CRC). Studies are planned to test whether Sprouty2 gene serves as prognostic marker of disease-free survival in advanced rectal cancer patients. Studies will also test whether reduction in Sprouty2 would regress tumor growth. We strongly believe that understanding the role of Sprouty2 gene in CRC will identify better strategies to treat patients.

PI_NAMEs: KHARE, SHARAD  (contact)

PROJECT_TERMS: Adenocarcinoma;adenoma;Affect;Archives;Azoxymethane;Binding;Biopsy;bisulfite sequencing;Cancer Etiology;Cancer Patient;Cessation of life;chemoradiation;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;colon cancer cell line;colon cancer patients;colon tumorigenesis;Colorectal Adenoma;Colorectal Cancer;CpG Islands;Data Set;Disease Progression;Disease-Free Survival;DNA;DNA Methylation;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Epigenetic Process;epigenetic regulation;Epithelium;Failure;Future;Genes;Growth;High-Throughput Nucleotide Sequencing;Immunocompromised Host;In Vitro;Individual;inhibitor;Intestines;Invaded;Investigation;KRASG12D;LoxP-flanked allele;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mesenchymal;Messenger RNA;metastatic colorectal;Methodology;Methylation;Mitogen-Activated Protein Kinases;Modeling;mouse model;mRNA Expression;Mucous Membrane;Multiomic Data;Mus;mutant;mutant mouse model;Mutation;new therapeutic target;novel;Oncogenes;Operative Surgical Procedures;Organoids;Pathology;Pathway Analysis;Patients;Phenotype;postnatal;Predisposition;Prognosis;prognostic;Prognostic Marker;Progress Reports;promoter;Promoter Regions;pyrosequencing;Receptor Protein-Tyrosine Kinases;Rectal Cancer;Regulation;Research;Research Personnel;resistance mechanism;responders and non-responders;Retrospective Studies;Role;SCID Mice;Signal Pathway;Signal Transduction;small hairpin RNA;targeted treatment;Testing;Therapeutic Intervention;Time;Tissues;tool;transcriptome sequencing;treatment strategy;tumor;tumor growth;Tumor Suppressor Proteins;tumorigenesis;Ulcerative Colitis;United States;Update;Xenograft Model

PROJECT_TITLE: Sprouty: Putative Oncogene in Colorectal Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ONCC-S (01)]


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Contraception/Reproduction;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Regenerative Medicine;Women's Health Research

ORG_CITY: RENO

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because complications associated with preterm birth are a leading cause of infant mortality in the United States. This project is relevant to the NICHD mission because itwill provide determine if TIMP-based engineered proteins can promote uterine quiescence for potential use as therapeutic agents to reduce preterm births.

PI_NAMEs: RAEESZADEH SARMAZDEH, MARYAM  (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Address;Affinity;Binding;Biochemical;Biological Assay;Birth;Cell Physiology;cervical remodeling;combinatorial;Data;Directed Molecular Evolution;Dose;drug candidate;drug testing;Engineering;Enzymes;experimental study;Family;Foundations;Future;Gelatinase A;Gelatinase B;Goals;health disparity;Human;human tissue;improved;in vivo;in vivo Model;Infant Mortality;Infection;Inflammatory;Inhibition of Matrix Metalloproteinases Pathway;inhibitor;Intervention;Libraries;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Mechanics;member;Metalloproteases;Mission;Mus;Myometrial;myometrium;nanomolar;National Institute of Child Health and Human Development;novel;overexpression;Oxytocin;Pathway interactions;Patients;perinatal health;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;pre-clinical;Pregnancy Outcome;Pregnant Uterus;premature;Premature Birth;Premature Labor;prevent;Process;Production;Protein Engineering;Proteins;Public Health;Recombinants;Research;Research Priority;response;Role;Scaffolding Protein;screening;side effect;Smooth Muscle;Surface;Techniques;Testing;Therapeutic;Therapeutic Agents;therapeutic protein;therapeutic target;Tissue Engineering;Tissue Inhibitor of Metalloproteinases;Tissues;Tocolysis;Tocolytic Agents;Toxic effect;United States;Uterine Contraction;Uterus;Variant;Woman;Yeasts

PROJECT_TITLE: Selective targeting of matrix metalloproteinases for developing preterm labor therapeutics

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Services;Palliative Care;Patient Safety;Primary Health Care

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Discussions between patients and physicians about end-of-life care preferences allow older adults to maintain control over their medical care at the end of life and reduce unwanted medical interventions. The emergency department visit provides a unique opportunity to promote these discussions among patients likely to benefit from these conversations. The proposed study will test an intervention which combines a certified video decision aid, a semi-structured conversation with a social worker, and secure electronic communication with the patient's primary provider and admitting physician to support end-of-life care discussions for older adults receiving care in the emergency department.

PI_NAMEs: VOLANDES, ANGELO  (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Accident and Emergency department;Address;Admission activity;Adult;Advance Care Planning;advanced disease;aged;Agreement;American;Black Populations;care preference;Caring;Certification;Cessation of life;Clinical;Clinical Trials;Cognitive;Communication;Consensus;Data;Decision Aid;Documentation;effectiveness evaluation;Effectiveness of Interventions;efficacy evaluation;efficacy trial;Electronic Health Record;Electronic Mail;Electronics;Emergency Care;Emergency Department patient;Emergency department visit;Emergency Department-based Intervention;Emergency Situation;empowerment;end of life;end of life care;ethnic minority;Ethnic Origin;Event;Family;Fright;Goals;health care service utilization;Health Expenditures;health literacy;Health Personnel;Health Status;high risk population;Hispanic Populations;hospital utilization;Hospitals;implementation strategy;impression;improved;Institute of Medicine (U.S.);Instruction;Intervention;intervention effect;Length of Stay;Life;loved ones;Measures;Medical;Modeling;Not Hispanic or Latino;Nursing Homes;older adult;older patient;Outcome;Outcome Assessment;Patient Preferences;Patients;Physicians;Positioning Attribute;preference;primary care patient;primary care provider;Process;Provider;Race;racial minority;Randomized;Randomized, Controlled Trials;Reporting;Research;satisfaction;secondary outcome;Secure;shared decision making;Social Workers;Structure;Subgroup;Testing;Time;treatment as usual;Treatment Efficacy;Update;Visit;Work

PROJECT_TITLE: Using the Emergency Department Visit to Promote Advance Care Planning

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: COLLEGE PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PUBLIC HEALTH RELEVANCE STATEMENT This research will contribute to understanding mechanisms that confer risk for suicidal ideation, planning, and attempts for Black children in middle childhood. Findings will assist in developing targeted and culturally relevant prevention and intervention efforts.

PI_NAMEs: DUNBAR, ANGEL S. (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Accounting;Address;Adolescence;Adolescent;adverse childhood events;adverse outcome;Age;age group;aged;Area;Behavior;Belief;Black race;Buffers;Characteristics;Child;Child Behavior;Child Development;Child Rearing;Childhood;Competence;computerized;coping;Data;Depressed mood;diaries;Discipline;Discrimination;Disparity;elementary school;emotion dysregulation;emotion regulation;Emotions;Equation;Exclusion;experience;Family;Feeling suicidal;Foundations;Frequencies;Goals;health assessment;ideation;Inequity;Intervention;intervention program;Interview;Lead;Link;Literature;Major Depressive Disorder;Mental Depression;Mental Health;metropolitan;middle childhood;minority children;Modeling;Neurocognitive;novel;novel strategies;Pain;pain relief;Parents;Participant;perceived discrimination;Perception;Policies;Preparation;Prevention;primary caregiver;programs;Prospective Studies;protective factors;Psychological Impact;psychological outcomes;psychosocial stressors;public health relevance;Race;racial bias;racial discrimination;racial disparity;racism;Records;recruit;reducing suicide;Reporting;Research;Risk;School-Age Population;Schools;Severities;Shame;skills;Socialization;Specificity;standard measure;stressor;Structural Racism;Structure;suicidal;suicidal behavior;suicidal risk;suicide rate;Surveys;Suspensions;teacher;Testing;theories;University Hospitals;Work;Youth

PROJECT_TITLE: Linking Racial Disparities in School Discipline to Black Youth Suicidality

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Pediatric;Precision Medicine

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because spondyloarthritis is the most common form of childhood arthritis in large parts of the world and although inactive disease is a realistic goal since the introduction of biologic agents we do not know if or how to de-escalate therapies with minimal morbidity. There is a critical need for imaging and serologic biomarkers to accurately predict flare after therapy de-escalation so that we can eliminate much of the guesswork associated with the current standard of care. This project is directly aligned with the program announcement (RFA-AR-20-001) as the primary goal is to leverage the infrastructure and resources of a funded parent trial to enhance its scientific content and value, improve the research community’s understanding of the clinically inactive disease state, and to test the utility of imaging and serologic biomarkers to guide treatment de-escalation decisions at point-of-care.

PI_NAMEs: WEISS, PAMELA FITCH (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Abate;Accounting;Address;Adolescent;Aftercare;Age;Ancillary Study;Anxiety;Apoptosis;Area;Arthritis;Back;Benign;Biological;Biological Markers;Biological Products;Biological Response Modifier Therapy;caregiver quality of life;CD3 Antigens;Cells;Child;Childhood;Chronic Childhood Arthritis;Clinical;clinical care;clinical predictors;clinically relevant;cohort;Communities;COVID-19 pandemic;CTLA4 gene;cytokine;Data Reporting;Databases;Decision Making;Demyelinating Diseases;Disease;disorder risk;Dose;Enrollment;Equipoise;evidence base;Family;Flare;Frequencies;Funding;Genetic Transcription;Goals;Image;imaging biomarker;Immune;immune checkpoint;Immunologic Markers;Immunologics;improved;infection risk;Inflammation;Inflammatory;Infrastructure;inhibitor;inhibitor therapy;Knowledge;Magnetic Resonance Imaging;Malignant Neoplasms;Memory;Messenger RNA;Mitogen-Activated Protein Kinases;Morbidity - disease rate;NIH Program Announcements;Nuclear;Outcome;Parents;Patients;Pelvis;Pharmaceutical Preparations;Phenotype;point of care;Population;pragmatic randomized trial;predictive marker;Predictive Value;Prevalence;Process;programmed cell death protein 1;Protocols documentation;Psoriasis;Public Health;Randomized;Receptor Activation;Recording of previous events;Relapse;Research;Residual state;Resources;Risk;ROC Curve;Role;Sacroiliac joint structure;Serology;side effect;Signal Transduction;Spondylarthritis;standard of care;T memory cell;T-Cell Activation Pathway;T-Cell Receptor;T-Lymphocyte Subsets;Testing;Time;TNF gene;tool;Withdrawal;Withdrawing Treatments;Work

PROJECT_TITLE: Immunological, serologic, and imaging biomarker predictors of flare in pediatric spondyloarthritis


ORG_CITY: OMAHA

ORG_NAME: OMAHA VA  MEDICAL CENTER

ORG_STATE: NE

PHR: Kidney transplantation is the preferred mode of replacement therapy for those with kidney failure. Since 1962, the VA National Transplant Program provides kidney transplants to Veterans at 8 VA Medical Centers as well as by contracted care across the US. About half of these patients will die prematurely by 10 years after transplant due to cardiovascular disease, while another half will suffer with graft failure and return to dialysis. Improving these outcomes is a critical unmet need. New therapies for type 2 diabetes mellitus (T2DM) such as SGLT2 inhibitors (SGLT2i) have had substantial positive impacts on patients with kidney disease, but they have not been in kidney transplant patients. In this application we will test the safety of using these agents in an open label fashion in kidney transplant recipients with T2DM. We will compare their outcomes to a cohort of kidney transplant recipients in the VA health system that are getting standard care treatment. We will also assess the economic impact of SLGT2i therapy in this patient population.

PI_NAMEs: MANNON, ROSLYN B (contact)

PROJECT_TERMS: absorption;Address;Adrenal Cortex Hormones;Adverse event;Albumins;Albuminuria;Allografting;Area;Calcineurin inhibitor;Cardiac;Cardiometabolic Disease;cardioprotection;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Caring;Cessation of life;Chronic Kidney Failure;Clinical;clinical care;Clinical Trials;cohort;Communities;Complex;Confusion;Contracts;cost;Cost Analysis;Creatinine;Cross-Sectional Studies;Data;data warehouse;Death Rate;Deterioration;Development;diabetes management;Diabetes Mellitus;diabetic;Dialysis procedure;Disease Management;Disease Progression;Drops;economic evaluation;economic impact;Eligibility Determination;End stage renal failure;Endocrine;Event;Exclusion;Formularies;Glomerular Filtration Rate;Glucose;Goals;graft failure;graft function;Graft Survival;Health;Health system;heart disease risk;Heart failure;High Prevalence;Hospitalization;Hypertension;Immunocompromised Host;Immunosuppression;Immunosuppressive Agents;improved;improved outcome;Incidence;Individual;Infection;Inferior;Informatics;Information Systems;inhibitor;inhibitor therapy;insight;Interdisciplinary Study;Investigation;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;Length;Malignant Neoplasms;Measures;Medical;Medical center;mortality;Multi-Institutional Clinical Trial;Nephrology;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;novel therapeutics;Observational Study;open label;Operative Surgical Procedures;Oral;Outcome;Participant;patient population;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Population;post-transplant;premature;prevent;primary outcome;Procedures;programs;prospective;Publishing;Quality of life;Randomized, Controlled Trials;Renal function;Replacement Therapy;Reporting;Risk;Risk Factors;Safety;safety and feasibility;safety assessment;safety testing;Serious Adverse Event;Serum;side effect;Sodium;standard care;success;symporter;Testing;Therapeutic;therapy outcome;Time;Translating;Transplant Recipients;Transplantation;transplantation therapy;Treatment Effectiveness;United States;urinary;Veterans

PROJECT_TITLE: An Exploratory Investigation of the Safety of Empagliflozin in Kidney Transplant Recipients (SEKTR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NEPH-N (01)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

ORG_STATE: NY

PHR: VA has recognized that Agent Orange, and more recently burn pit, exposure is associated with development of several malignancies including the most common soft tissue cancer, fibrosarcoma. Patients with advanced cases of fibrosarcoma are resistant to chemo, radiation, and biologic therapies, which results in poor long-term survival. An effective solution is to target essential cancer growth and metastasis pathways. This Validation study will screen for novel small molecules that induce degradation of a therapeutic target protein Acss2, a lynchpin protein in a key signaling pathway that promotes cancer growth and metastasis. The proposed studies will identify hits in a primary screen, validate hits in a secondary screen, and evaluate their effectiveness on endogenous Acss2 in a tertiary screen. Candidates that meet pre-established criteria will be designated lead candidates and will undergo further optimization in future efforts. The Potential Impact on Veterans Health Care gained from these studies is development of novel first-in-class drugs for treatment of advanced stage fibrosarcoma in Veterans.

PI_NAMEs: GARCIA, JOSEPH ANTHONY (contact)

PROJECT_TERMS: Acetate-CoA Ligase;Acetates;agent orange;B-Cell Leukemia;bHLH-PAS factor HLF;Biological Assay;Biological Response Modifier Therapy;burn pit;cancer cell;candidate selection;Cell Line;Cell model;Cell Nucleus;Cell Survival;Cells;Chemicals;chemotherapy;Chimeric Proteins;Chronic;Coenzyme A Ligases;Collaborations;Custom;Degradation Pathway;deprivation;Development;Diversity Library;Effectiveness;Electrostatics;Elements;environmental stressor;Enzymes;Family member;Fatty Acids;fibrosarcoma;Firefly Luciferases;Future;Genome;Glucose;Goals;Growth;Half-Life;Healthcare;high throughput screening;Hodgkin Disease;Hydrophobicity;Hypoxia;Hypoxia Inducible Factor;Impairment;lead candidate;Length;Lipids;loss of function mutation;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Masks;Mediating;member;Metabolism;Molecular Target;mouse model;Multiple Myeloma;Mus;Mutation;Neoplasm Metastasis;Non-Hodgkin's Lymphoma;novel;novel anticancer drug;Nuclear;Oncogenic;overexpression;Oxygen;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Point Mutation;pre-clinical;Primary Neoplasm;Property;protein degradation;Proteins;Radiation therapy;Reporter;Resistance;respiratory;Role;Signal Pathway;Signal Transduction;Signal Transduction Pathway;small molecule;small molecule libraries;soft tissue;Soft Tissue Neoplasms;Soft tissue sarcoma;Solid Neoplasm;stable cell line;Stress;Structure;Testing;Therapeutic;therapeutic target;transcription factor;tumor;tumor growth;Tumor Promotion;Tumor-Derived;validation studies;Veterans

PROJECT_TITLE: First-in-class small molecules for treatment of soft tissue sarcoma and other cancers associated with Agent Orange exposure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ONCB-A (01)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research

ORG_CITY: RICHMOND

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Colorectal cancer (CRC) is among the most common and deadly forms of cancer, and the racial CRC disparity in South Carolina exceeds the national average. This study will use a biobehavioral case-control design to determine whether the disruption of circadian rhythms and sleep, including their genetic and epigenetic (DNA methylation) correlates, is associated with inflammation or colorectal adenomas among African- and European- American patients receiving a screening colonoscopy. Our study will rigorously evaluate whether circadian- based factors may serve as novel, modifiable targets for CRC prevention.

PI_NAMEs: BURCH, JAMES  (contact)

PROGRAM_OFFICER_NAME: SIMONDS, NAOKO ISHIBE

PROJECT_TERMS: Aberrant DNA Methylation;Address;adenoma;Adenomatous Polyps;Adverse effects;African;African American population;American;Anti-Inflammatory Agents;Apoptosis;Automobile Driving;Behavioral;beta catenin;Binding;biobehavior;Biological Factors;c-myc Genes;cancer health disparity;cancer risk;case control;Case/Control Studies;Cell Physiology;Cell Proliferation;Chronic;circadian;Circadian Dysregulation;Circadian gene expression;Circadian Rhythms;Colonic Neoplasms;Colonoscopy;Colorectal Adenoma;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;Communities;Coxibs;Data Collection;design;Detection;Development;Diet;diet and exercise;DNA Methylation;DNA Repair;Early Diagnosis;Endocrine;Epigenetic Process;European;experience;Fatigue;gastrointestinal;Gastrointestinal tract structure;Gene Expression;Genes;Genetic;Genetic Variation;Genotype;Hormone secretion;Hormones;Human;human tissue;Immune;Immunologic Surveillance;Immunosuppression;improved;Incidence;Inflammation;Inflammation Mediators;Inflammatory;Interleukin-6;Jet Lag Syndrome;Leukocytes;Light;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Melatonin;Methylation;Minisatellite Repeats;modifiable risk;Molecular;mortality;mRNA Expression;Normal tissue morphology;novel;Oncogenes;Pathway interactions;Patients;Pattern;Peripheral;physical inactivity;poor sleep;Predisposition;Prevention;Prevention trial;Process;promoter;prospective;Race;racial difference;receptor;Research;Retrospective cohort study;Risk;Risk Factors;Role;screening;screening disparities;Seminal;Services;shift work;Signal Transduction;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;social;socioeconomics;South Carolina;Stress;Symptoms;Testing;Tissues;TNF gene;transcriptome;tumor;tumor growth;Tumor Suppressor Proteins;United States;Variant;XPA gene

PROJECT_TITLE: Role of Circadian Factors in Inflammation and Colorectal Adenoma Risk


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Chronic pain is a major health concern for returning Veterans, and non-opioid treatment is a priority of the Veterans Administration. Weighted Blankets (WB) have shown large benefits for improving both anxiety and sleep disturbance, frequent comorbidities that amplify chronic pain. Decreasing sleep disturbance among Veterans with chronic pain has the potential to greatly reduce the impact of pain. Indeed, our data suggest that WBs can also reduce pain, especially in individuals with higher anxiety or poorer sleep. Yet, there is lack of information on whether WBs improve pain and sleep in Veterans suffering from chronic pain. Our proposed randomized controlled trial will identify the effects of a WB on chronic pain and sleep disturbance, and the relationship between these clinical factors. The proposed research findings will provide critical evidence for effects on pain and sleep disturbance for this novel, accessible and fully remote intervention. Study results will inform both future research and treatment of chronic pain.

PI_NAMEs: CASE, LAURA K (contact);STRIGO, IRINA A

PROJECT_TERMS: actigraphy;Acute Pain;Adherence;Adult;Affective;Analgesics;Anxiety;Area;arm;Arousal;Cellular Phone;chronic musculoskeletal pain;chronic pain;chronic pain management;Clinical;Clinical Treatment;comorbidity;comparative efficacy;Complementary therapies;cost;Data;diaries;Ecological momentary assessment;efficacy evaluation;Emotional;falls;Goals;Health;Healthcare Systems;improved;indexing;Individual;innovation;insight;Intervention;Life;Light;Measures;Mediating;Mediation;Medical;Mental disorders;Methods;non-drug;non-opioid analgesic;novel;Opioid;opioid use;Outcome;Outcome Measure;Pain;pain catastrophizing;Pain interference;Pain management;Pain Measurement;Pain quality;pain reduction;pain sensitivity;Participant;Patients;Physiological;poor sleep;Population;pressure;primary care provider;primary outcome;Provider;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;recruit;remote intervention;Research;Research Priority;response;San Francisco;Self-Injurious Behavior;Sensory;Severities;Sleep;Sleep disturbances;Sleep Fragmentations;sleep quality;Sleeplessness;Testing;Time;tool;United States Department of Veterans Affairs;Veterans

PROJECT_TITLE: RCT of a Weighted Blanket to Reduce Pain in Veterans with Chronic Pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURP-N (01)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Liver Disease

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Mechanisms of Insulin resistance in Man More than 400 million people in the world have either type 2 diabetes or pre-diabetes. The diagnostic hallmark of these conditions is elevated blood sugar levels first thing in the morning. Therefore, this application focuses on how, when and why does the liver release excess glucose into the blood stream during the day and at night in people with type 2 diabetes and whether certain antidiabetic medications can modulate some of the causal factors related to high blood sugar in order to develop rational approaches for and management of type 2 diabetes.

PI_NAMEs: BASU, RITA  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TITLE: Mechanisms of Insulin Resistance in Man

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Nutrition;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: MANASSAS

ORG_NAME: BENTEN TECHNOLOGIES, INC.

PHR: PROJECT NARRATIVE The innovative platform MILC is designed to provide an integrated and comprehensive professional and social support network with personalized breastfeeding (BF) education to target exclusive breastfeeding (EBF) and any BF behaviors in low-income Hispanic women. Formative research conducted for the development of MILC and results from pilot testing will help guide completion of the development and testing of this prototype that specifically caters to Hispanic women. In the long-term, MILC has the potential to increase the rates of EBF and any BF up to 12 months.

PI_NAMEs: MA, TONY XUYEN (contact);WASHIO, YUKIKO

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Academy;Address;African American;American;Asthma;Behavior;Belief;Board Certification;Breast Feeding;Businesses;Caring;Centers for Disease Control and Prevention (U.S.);Certification;chatbot;Child;Chronic Disease;Clinical;Collaborations;commercialization;Communication;Communication Tools;Complementary Feeding;Control Groups;design;Development;Diabetes Mellitus;Diarrhea;Drops;Education;encryption;ethnic disparity;ethnic minority population;Exclusive Breastfeeding;Face;feeding;Gastroenteritis;group intervention;Health Benefit;Healthcare Systems;Hispanic;Hispanic Populations;Hispanic Women;Hospitals;Hour;Human Milk;Hypertension;improved;Incentives;individual patient;Infant;Infant formula;innovation;Insurance;interest;International;Intervention;Interview;Investments;Lactation;Lactation consultant;Life;Low income;Medicaid;Methodology;mHealth;Minority Groups;Mobile Health Application;Modality;Mothers;multi-component intervention;Nipples;Not Hispanic or Latino;Obesity;Participant;Pediatrics;peer;peer support;Perception;Periodicals;Phase;pilot test;Population;Precede-Proceed Model;premature;primary care provider;Principal Investigator;Privacy;Professional counselor;programs;prototype;racial minority population;Randomized, Controlled Trials;Recommendation;Reporting;Research;Respiratory Tract Infections;Risk;Scheme;Secure;Small Business Innovation Research Grant;Social support;Structure;Sudden infant death syndrome;support network;System;telehealth;Testing;Time;United States;University Hospitals;usability;user centered design;virtual;Weaning;Woman;Work

PROJECT_TITLE: Multi-modal Intervention for Lactation Care (MILC) will be a mHealth platform to increase


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Stroke

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE . Acute ischemic stroke caused by occlusion of the vertebral or basilar arteries is a devastating disease that results in high rates of death and disability. Patients with vertebral or basilar artery occlusions often undergo endovascular thrombectomy treatment to restore blood flow in these vessels, which is thought to improve the chances of a good outcome in these patients. The goal of PRECISE is to determine if advanced cerebral perfusion imaging can identify a subset of patients with vertebral or basilar artery occlusion who are more likely to benefit from endovascular thrombectomy. The results of PRECISE will improve our ability to identify patients for emergency thrombectomy and may lead to improved patient selection and prognostication in this understudied stroke population.

PI_NAMEs: ALBERS, GREGORY W (contact);HEIT, JEREMY J

PROGRAM_OFFICER_NAME: FARACO, CARLOS CESAR

PROJECT_TERMS: Acute;Address;Adult;Aftercare;Angiography;Anterior;anterior cerebral artery;Area;artery occlusion;basilar artery;Blood flow;brain magnetic resonance imaging;Brain region;brain tissue;brain volume;Cause of Death;Cell Nucleus;cerebral artery;Cerebrum;Cervical;Cessation of life;Circulation;Clinical;clinical care;Cohort Studies;Data;Death Rate;design;disability;Disease;effective therapy;Emergency Situation;endovascular thrombectomy;Enrollment;Evaluation;Exclusion;Exhibits;Future;Goals;Hour;Image;Image Analysis;improved;Infarction;Injury;insight;Ischemia;Ischemic Stroke;Knowledge;Magnetic Resonance Imaging;Medical;Modernization;Morphologic artifacts;Multicenter Studies;neuroimaging;neuroprotection;novel;Outcome;Patient Selection;patient subsets;Patients;Perfusion;perfusion imaging;Population;primary endpoint;prognostic;prognostication;prospective;Prospective, cohort study;Protocols documentation;Randomized;randomized trial;Reperfusion Therapy;Reporting;response;Retrospective Studies;Selection for Treatments;Severities;Site;Specific qualifier value;Specificity;Stroke;stroke patient;stroke symptom;Structure;Symptoms;Thrombectomy;Tissues;treatment trial;trial comparing;United States;Validation;vertebral artery;X-Ray Computed Tomography

PROJECT_TITLE: PRECISE (PeRfusion imaging to identify postErior CIrculation candidateS for thrombectomy)

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Heart Disease;Heart Disease - Coronary Heart Disease;Pain Research;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Aging is associated with significant declines in muscle mass, strength, and physical performance, all of which lead to disability, loss of independence, and poor clinical outcomes. Currently, health care providers have no treatment options to offer their patients to slow declines in physical function. Evidence suggests that statins could be an effective treatment for preserving physical function by preventing disabling chronic conditions; however, a large number of patients discontinue statins because of side effects including muscle pain and weakness. Thus, determining whether statins can preserve physical function and independence in older adults is needed to inform treatment guidelines for the use of statins in older adults.

PI_NAMEs: HOUSTON, DENISE KATHRYN (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: Activities of Daily Living;Admission activity;Affect;Age;aged;Aging;aging population;aging related;Ancillary Study;Anti-Inflammatory Agents;Antioxidants;atorvastatin;Cholesterol;Chronic;Clinical;Clinical Research;Clinical Trials Design;Cognition;Coronary heart disease;cost effective;Data;Dementia;design;disability;Disabling;effective therapy;Equilibrium;Evaluation;Event;experience;Fatigue;follow-up;functional decline;Gait speed;Health;Health Personnel;Heart failure;immunoregulation;improved;Infrastructure;Lipids;Lower Extremity;Measures;meter;middle age;Mobility disability;mortality;multiple chronic conditions;Muscle;muscle form;Muscle Weakness;Myalgia;Myocardial Infarction;Nursing Homes;Observational Study;older adult;Outcome;Pain;Parents;Participant;patient oriented;patient population;Patient Recruitments;Patient Self-Report;Patient-Focused Outcomes;Patients;Performance;Peripheral arterial disease;Physical activity;Physical Function;Physical Performance;physically handicapped;Placebo Control;Placebos;Pragmatic clinical trial;preservation;prevent;Property;Quality of life;Random Allocation;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Resources;Risk Reduction;Series;side effect;Site;Stroke;symptom treatment;Symptoms;System;Testing;Therapeutic;Time;treatment arm;treatment group;treatment guidelines;United States Department of Veterans Affairs;Walking

PROJECT_TITLE: The PREVENTABLE Physical Performance Ancillary Study

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ORG_NAME: VA VETERANS ADMINISTRATION HOSPITAL

PHR: Fatty liver disease is an inflammatory response to accumulation of toxic metabolites within the liver. In United States Veterans, the progression of fatty liver disease to liver inflammation/fibrosis/cirrhosis will soon be the leading cause of liver transplantation; creating a challenge for our country’s Health Care budget. The metabolic pathways that protect fatty liver disease’s progression to inflammation are under intense study. Recent findings provide evidence that abnormal hepatocyte cholesterol metabolism drives fatty liver’s transition to inflammation. StarD5, a unique protein involved in intracellular cholesterol movement and highly expressed in liver cells, appears able to provide an adaptive protective response; and may play a controlling role to protect the liver’s progression to inflammation in fatty liver disease. The proposal outlines a framework of studies to define this novel hypothesis; ones likely to unveil new pathways for pharmacological control of cholesterol/lipids and its associated pathologies.

PI_NAMEs: PANDAK, WILLIAM M (contact)

PROJECT_TERMS: Ablation;Acute;Binding;Binding Proteins;Biological;Budgets;Carrier Proteins;Cell membrane;Cells;Characteristics;Cholesterol;cholesterol control;Cholesterol Homeostasis;Cirrhosis;Country;Development;Disease Progression;Endoplasmic Reticulum;endoplasmic reticulum stress;expression vector;Fatty Liver;fatty liver disease;feeding;Fibrosis;fluidity;Gene Expression;Gene Expression Profile;Genes;Glucose;Healthcare;Hepatocyte;Hydrolysis;in vivo;Incubated;Inflammation;Inflammatory;Inflammatory Response;inorganic phosphate;Insulin;Insulin Resistance;knock-down;lipid transfer protein;lipidomics;Lipids;Lipoproteins;Liver;Liver Fibrosis;liver inflammation;liver transplantation;loss of function;Macrophage;Maintenance;Mediating;member;Membrane;Membrane Fluidity;Membrane Proteins;Metabolic Pathway;military veteran;Molecular;mouse model;Movement;Mus;Mutate;non-alcoholic fatty liver disease;novel;Oils;Organelles;overexpression;Pathology;Pathway interactions;Pattern;pharmacologic;Phosphatidylinositols;Physiological;Play;prevent;protective pathway;protein expression;Proteins;Regulation;response;restoration;Role;Route;Serum;single-cell RNA sequencing;Site;Sphingolipids;Stains;Steatohepatitis;steroidogenic acute regulatory protein;Stress;stressor;Tissue Harvesting;Transcriptional Activation;Transfection;Triglycerides;United States;uptake;vector;Very low density lipoprotein;vesicle-associated membrane protein;Veterans;western diet;Wild Type Mouse

PROJECT_TITLE: An ER Stress Inducible START Domain Cholesterol Transport Protein, StarD5; and Unique Role in Fatty Liver Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 GAST-L (01)]


FUNDING_MECHANISM: OTHERS

ORG_CITY: White River Junction

ORG_NAME: WHITE RIVER JUNCTION VA MEDICAL CENTER

ORG_STATE: VT

PHR: Relevance to Veterans’ health and healthcare: Shockwave-induced, blast traumatic brain injury (bTBI) is a significant problem for U.S. service members, including combat Veterans. The debilitating neuropsychiatric consequences associated with bTBI necessitate an effective intervention. The current application aims to meet this critical need by determining the utility of neuromodulation and pharmacotherapy to reduce neuroinflammation, which may mediate associated neuropsychiatric impairment. In a rodent model, we will test two treatments that target the same anti-inflammatory pathway, vagus nerve stimulation (VNS) and anatabine, with the ultimate goal of human translation. Both VNS and anatabine have shown efficacy in experimental testing but have yet to be used for bTBI. If successful, these treatments have the potential to improve the quality of life of service members and advance the standard of care for military personnel who have experienced bTBI.

PI_NAMEs: NOLLER, CRYSTAL M (contact)

PROJECT_TERMS: Acute;Address;Affect;Amygdaloid structure;Animal Disease Models;Anterior;Anti-Inflammatory Agents;Anxiety;Anxiety Disorders;Area;Autonomic nervous system;battlefield injury;Behavior;Behavioral Assay;Blast Phase;blood-brain barrier permeabilization;Brain;Brain Injuries;Brain region;Canada;career;Center for Translational Science Activities;Cessation of life;cholinergic;Cholinergic Agonists;Chronic;Chronic Phase;cingulate cortex;Closed head injuries;Cognitive deficits;combat veteran;comparison control;Consultations;cytokine;Data;design;Devices;disability;effective intervention;effectiveness evaluation;Epidemic;Epilepsy;Equipment;experience;Family;FDA approved;Fright;Functional disorder;General Population;Goals;Head;Health;Health Services Research;Healthcare;Hippocampus;Histology;Human;Immune;immune activation;Immune response;Immune system;Immunohistochemistry;immunoregulation;Impairment;improved;Incidence;Inflammation;Inflammatory;Inflammatory Response;Infrastructure;Injury;Insula of Reil;Investigation;K-Series Research Career Programs;Knowledge;Lead;Link;Mediating;Medical center;Mental Depression;Mentors;Microscopy;Microsurgery;Military Personnel;Modeling;Mus;Nervous System Trauma;Neuroanatomy;neurobehavioral;Neuroimmune;neuroinflammation;neurological rehabilitation;neuropathology;neuropsychiatric disorder;neuropsychiatric symptom;neuropsychiatry;neuroregulation;novel;Pathway interactions;Peripheral;Persons;Pharmacotherapy;Physicians;Positioning Attribute;Post-Traumatic Stress Disorders;pre-clinical;Pre-Clinical Model;Quality of life;Recovery of Function;Reflex action;rehabilitation research;Research;Research Activity;research and development;Research Personnel;Research Priority;Research Support;response;Rodent;Rodent Model;Safety;Scientist;service member;Severities;Shock;standard of care;Standardization;statistics;stress disorder;System;targeted treatment;TBI treatment;Testing;Time;tool;Training;Translations;Trauma;Traumatic Brain Injury;Tube;United States;vagus nerve stimulation;Veterans;War;Work

PROJECT_TITLE: Harnessing the Cholinergic Inflammatory Reflex to Alter Neuroinflammation and Neuropsychiatric Consequences Following Traumatic Brain Injury

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI VA MEDICAL CENTER RESEARCH

PHR: The prevalence of health factors that compromise the immune systems of US veterans and predispose them to infection with opportunistic pathogens like Pneumocystis is significant. Besides infection with HIV, obesity in the US has increased over the past several decades. Obesity is linked to more than 60 chronic diseases, including cancers. In 2014 (the most recent update), the VA estimated that 78% of US veterans (including men, women and ethnic minorities) were overweight or obese (Spotlight on Obesity, May 2020) rendering them susceptible to cancers, other immune debilitating diseases, and opportunistic infections like Pneumocystis pneumonia. Opioid drug overdoses of US military veterans have increased by 53% from 2010- 2019, establishing another susceptible veteran population who are often co-infected with HIV and HCV.

PI_NAMEs: CUSHION, MELANIE T (contact)

PROJECT_TERMS: 3-Dimensional;Allergic Reaction;Allogenic;Amphotericin B;Anidulafungin;Animals;anti-fungal agents;Award;Azoles;Biological Products;Cells;chemotherapy;Chronic Disease;Clinic;Clinical;Combined Modality Therapy;Data;Dihydrofolate Reductase;Dihydropteroate Synthase;Disease;drug efficacy;Drug Synergism;efficacy testing;Enzymes;Eosinophilia;ethnic minority;Event;Exanthema;Family;Folic Acid;fungus;Genes;glucan synthase;Goals;Harvest;Health;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;HIV;HIV Infections;HIV/HCV;Human;Immune;Immune system;Immunocompromised Host;immunosuppressed;Immunosuppression;improved;in vivo;Infection;inhibitor;innovation;insight;Interruption;Life Cycle Stages;Link;Lung;Malignant Neoplasms;Mammalian Cell;Mammals;Mediating;men;Meta-Analysis;military veteran;Modeling;mortality;Mus;Nature;New Agents;novel;novel strategies;novel therapeutics;Obesity;opioid overdose;Opportunistic Infections;opportunistic pathogen;Organ Transplantation;Outcome;Overweight;pathogenic fungus;Pathway interactions;Patients;Pentamidine;Pharmaceutical Preparations;Pharmacotherapy;Phase;Pneumocystis;Pneumocystis carinii;Pneumocystis carinii Pneumonia;Pneumonia;Population;Positioning Attribute;predictive modeling;Predisposition;Prevalence;prophylactic;Prophylactic treatment;Rattus;Reaction;Recovery;Refractory;Regimen;Reporting;Rheumatism;Rodent Model;Sexual Reproduction;single-cell RNA sequencing;Solid;Sulfamethoxazole;Symptoms;synergism;T-Lymphocyte;Time;Translations;transmission process;treatment choice;treatment duration;treatment effect;Treatment Efficacy;treatment response;Trimethoprim;Trimethoprim-Sulfamethoxazole;Update;Veterans;Vulnerable Populations;Withdrawal;Woman

PROJECT_TITLE: Targeting the Sexual Cycle of Pneumocystis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 INFB-K (01)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Complementary and Integrative Health;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Rehabilitation;Social Determinants of Health

ORG_CITY: EUGENE

ORG_NAME: DOUBLE S INSTRUCTIONAL SYSTEMS

ORG_STATE: OR

PHR: Project Narrative  There are no currently available mindfulness-based stress reduction interventions specifically tailored for adults with intellectual disabilities (ID). And, while there are a number of efficacious mindfulness-based stress management interventions for the general population, these approaches have significant limitations for use by people with ID – in that they do not address this populations unique learning needs. There is a need for an adapted approach giving individuals with ID low cost, immediate access to the help and support they need. This project addresses a significant public health need by developing and evaluating a low-cost, accessible online integrated mindfulness-based stress reduction program that can be easily implemented by individuals in this population with the support of their care providers to reduce their stress and strengthen their healthy coping skills.

PI_NAMEs: SHEEHAN, MARTIN R. (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Address;Adherence;Adult;Age;Anxiety;Area;Attention;Awareness;behavior change;Behavioral;bullying;care providers;Cellular Phone;Cognitive;community living;Computers;contextual factors;coping;Coping Skills;cost;cost effective;design;Development;Devices;disability;Discrimination;E-learning;Educational process of instructing;efficacious intervention;Employment;Ethnic Origin;Evaluation;Exercise;experience;Face;Family;Family member;Focus Groups;foot sole;foster care;foster parent;Frequencies;Gender;General Population;Goals;Home;implementation barriers;improved;Individual;Individuals with physical disabilities;innovation;Instruction;Intellectual functioning disability;interest;Intervention;Learning;Link;Marketing;Measures;Mental Depression;Mental Health;mind/body;mindfulness;mindfulness based cognitive therapy;mindfulness intervention;mindfulness-based stress reduction;Modeling;Monitor;motivated behavior;National Center for Complementary and Integrative Health;online delivery;Online Systems;Outcome;Persons;Phase;pilot test;Population;Population Programs;primary outcome;Process;programs;prototype;Provider;Public Health;Published Comment;recruit;Research;Resources;response;Risk;satisfaction;secondary outcome;severe behavior problem;skills;social exclusion;social skills;Social support;Socialization;Stress;Stress and Coping;stress management;stress reduction;Structure;support network;System;Tablets;Target Populations;technology development;Testing;Text;Therapeutic;Therapeutic Intervention;Time;tool;Touch sensation;Training;Training Activity;Training Programs;Underserved Population;United States;usability;web site;web-based intervention;Work;Writing

PROJECT_TITLE: Stress, Mindfulness, and People with Intellectual Disabilities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-C (10)]


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Nonalcoholic fatty liver disease presents a significant burden for the VA Healthcare System and hepatocellular carcinoma is among its most consequential complication. Because the underlying mechanism(s) of the development of hepatocellular carcinoma in patients with nonalcoholic fatty liver disease are poorly understood, treatment and chemoprevention options are lacking. In this proposal, we will study the effects of lipid pathways, including statins, on the emergent YAP/TAZ oncogenic pathway in hepatocellular carcinoma. We will test the hypothesis that treating normal and cancer cells with a combination of lipid-modifying agents and mTORC1 targets (part of the YAP/TAZ pathway) will affect cell growth and proliferation. Thus, the most translatable outcomes of the findings from this proposal could be the identification of chemoprevention methods and therapeutic targets important in the progression of nonalcoholic fatty liver disease to hepatocellular carcinoma.

PI_NAMEs: BENHAMMOU, JIHANE  (contact)

PROJECT_TERMS: Address;Affect;Architecture;bariatric surgery;Biology;California;cancer cell;Cancer Patient;Cell Culture Techniques;cell growth;cell motility;Cell Nucleus;Cell Proliferation;Cellular Membrane;Chemoprevention;Cholesterol;Cirrhosis;Clinical;Collaborations;Complication;curative treatments;Data;desaturase;design;Development;Early Diagnosis;Early treatment;Eligibility Determination;Enhancers;Environment;Enzymes;experimental analysis;experimental study;Fostering;gene environment interaction;Gene Expression;Generations;Genes;Genetic;Goals;Growth;Guanosine Triphosphate;Healthcare Systems;Hepatocarcinogenesis;Hepatocyte;high risk population;Human;Human Genetics;Human Resources;improved;In Vitro;Incidence;inhibitor;Institution;intrahepatic;knock-down;Knock-out;Laboratories;Link;Lipid Biochemistry;lipid biosynthesis;Lipids;lipophilicity;Liver;liver transplantation;Los Angeles;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;Measures;meetings;Mentors;Mentorship;Metabolic syndrome;Methods;mevalonate;Mevalonic Acid;military veteran;Modeling;Monounsaturated Fatty Acids;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;Normal Cell;novel;Obesity;Oncogenic;Organoids;Outcome;Pathogenesis;Pathway interactions;patient subsets;Patients;pharmacologic;Phosphorylation;Play;Population Genetics;precision oncology;Primary carcinoma of the liver cells;professor;programs;Prospective cohort;Proteins;Regulation;Research;Research Personnel;Resources;rho;rho GTP-Binding Proteins;RNA;Role;Sampling;Saturated Fatty Acids;screening;Signal Transduction;Signal Transduction Pathway;Single Nucleotide Polymorphism;SRE-1 binding protein;Stearoyl-CoA Desaturase;stearoyl-coenzyme A;success;Testing;therapeutic target;Time;Training;Transcription Coactivator;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Transplant Recipients;Tumor Markers;tumor microenvironment;Universities;Untranslated RNA;Veterans

PROJECT_TITLE: A lipid signaling network through stearoyl Co-A desaturase regulates hepatocellular carcinogenesis through YAP/TAZ activity


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Orphan Drug;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Myosins are molecular motors responsible for generating much of the force in the human body, including the heartbeat and the movement of limbs. Small changes to the cardiac myosin gene can cause cardiomyopathies, the leading causes of sudden cardiac death in young adults. This proposal aims to combine molecular simulations with experiments to understand how these subtle changes to the myosin gene create such large effects in protein function and how we can develop novel drugs to treat cardiomyopathies and other common heart conditions.

PI_NAMEs: MELLER, ARTUR  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Active Sites;Address;Affect;Affinity;ATP phosphohydrolase;Back;beta-Lactamase;beta-Myosin;Binding;Binding Sites;Biological Assay;Biomedical Research;Biophysical Process;Cardiac;Cardiac Myosins;Cardiomyopathies;Cell Physiology;Cells;Clinic;Clinical;clinically relevant;Collaborations;Data;Data Science;design;Dilated Cardiomyopathy;Disease;disease phenotype;disease-causing mutation;Dissociation;Distal;Drug Design;drug discovery;drug response prediction;Drug Targeting;Enzymes;Equilibrium;experimental study;frontier;Future;G-Protein-Coupled Receptors;Genes;Goals;Heart;Heart Diseases;Heart failure;high throughput screening;Hospitalization;Human;Human body;Hypertrophic Cardiomyopathy;in silico;Individual;individualized medicine;Inherited;inhibitor;insight;Letters;limb movement;Link;Machine Learning;Methods;Missense Mutation;Modeling;Molecular;Molecular Conformation;molecular dynamics;Molecular Motors;Motor;Movement;Mutation;Myosin ATPase;novel;novel therapeutic intervention;novel therapeutics;Outcome;Pathogenicity;patient prognosis;Patients;Pharmaceutical Preparations;preference;Prevalence;Probability;Protein Dynamics;protein function;Protein Isoforms;Proteins;Publications;Recombinants;Resolution;simulation;Site;small molecule;Specificity;Structure;sudden cardiac death;Testing;Therapeutic;Therapeutic Intervention;tool;United States;United States National Institutes of Health;Universities;Variant;variant of unknown significance;virtual;Washington;young adult

PROJECT_TITLE: Modeling Hidden Myosin Structural States to Predict Drug Specificity and Disease Phenotypes


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative There is growing consensus that dysfunction of cortico-striatal circuits is a key component of psychiatric illnesses. Moreover, there is compelling evidence that points to neurodevelopmental origins for most psychiatric disorders. This study will examine the anatomical underpinnings of functional integration through the cortico-striatal neural network and changes in its circuitry during early postnatal development.

PI_NAMEs: HABER, SUZANNE N (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: 3-Dimensional;Adaptive Behaviors;Adult;Age;Anatomy;Area;Basal Ganglia;Behavior;behavioral study;Brain region;cell cortex;Cells;Cognitive;cognitive control;Complex;computerized tools;connectome;Consensus;Corpus striatum structure;critical period;Data;density;Development;experimental study;Fiber;frontal lobe;Functional disorder;Ganglia;Goals;gray matter;Habits;human imaging;human subject;imaging study;Incentives;Injections;insight;Label;Learning;Link;Maps;mature animal;Mental disorders;Motivation;Motor;motor control;Myelin;myelination;neural network;nonhuman primate;Pattern;Play;Positioning Attribute;postnatal;postnatal development;Prefrontal Cortex;Projections and Predictions;Rewards;Role;Sampling;Shapes;Site;Structure;System;Time;Tracer;Variant;Ventral Striatum;women versus men

PROJECT_TITLE: Continuity of the Limbic Circuit Through the Basal Ganglia

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Emphysema;Lung;Lung Cancer;Pulmonary Fibrosis;Radiation Oncology

ORG_CITY: DURHAM

ORG_NAME: XEMED, LLC

ORG_STATE: NH

PHR: NARRATIVE  Cancer radiation treatment plans that employ lung functional avoidance methods require 3D maps that differentiate regions of healthy lung function from regions of compromised tissue to deliver sufficient dose to the tumor while preserving as much functioning lung as possible. Hyperpolarized xenon-129 MRI can provide maps of ventilatory function and gas exchange to the bloodstream. Improving treatment plans based on this novel imaging modality could reduce risk or severity of radiation pneumonitis and improve post-treatment quality of life.

PI_NAMEs: KADLECEK, STEPHEN J;RUSET, IULIAN CONSTANTIN (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: 3-Dimensional;Acute;Address;Affinity;Aftercare;Alveolar wall;Authorization documentation;Biological Markers;Blood;Blood Circulation;Breathing;Cancer Patient;cancer radiation therapy;Characteristics;chemotherapy;Chronic;Climacteric;cohort;Communication;comorbidity;Consensus;Control Groups;cost;Development Plans;dosage;Dose;Dose Rate;Enrollment;Erythrocytes;Esophagus;Exhibits;Fibrosis;follow-up;four-dimensional computed tomography;functional decline;Functional Imaging;Gases;Heart;Hemoglobin;Heterogeneity;high resolution imaging;imaging modality;improved;improved outcome;Incidence;individualized medicine;Industrialization;industry partner;Infrastructure;Institutional Review Boards;Insurance Carriers;Intensity-Modulated Radiotherapy;Investments;Kinetics;Location;loss of function;Lung;Magnetic Resonance Imaging;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Marketing;Measures;meetings;Methods;novel;open label;Organ;Outcome;Patient Selection;patient stratification;Patients;Performance;Perfusion;Phase;Phase II Clinical Trials;Phase III Clinical Trials;Positron-Emission Tomography;preservation;primary endpoint;Procedures;Protocols documentation;Public Health;Pulmonary Emphysema;Pulmonary Fibrosis;pulmonary function;Pulmonary function tests;Pulmonary Inflammation;Quality of life;Radiation;Radiation Dosage;Radiation Dose Unit;Radiation Fibrosis;Radiation Pneumonitis;Radiation therapy;Randomized;recruit;research and development;Research Personnel;Resolution;Risk;Risk Reduction;secondary endpoint;Series;Services;Severities;Signal Transduction;single photon emission computed tomography;Site;Solubility;Spirometry;standard of care;Structure;Structure of parenchyma of lung;Techniques;Technology;Tissues;Tracer;Translating;translational study;treatment planning;Treatment Protocols;tumor;United States National Institutes of Health;ventilation;Vertebral column;Writing;Xenon

PROJECT_TITLE: Lung Functional Avoidance Radiotherapy Using Hyperpolarized Xenon MRI


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Topical Microbicides;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative While prevention measures for HIV have made significant progress, such as PrEP, these measures are often either ignored, misused, or non-negotiable for the female partner; therefore, there is a clear need world-wide for new approaches for the prevention HIV infections that are female controlled. In this application we plan to develop a synthetic mRNA-based approach for the delivery of broadly neutralizing antibodies against HIV to the female reproductive tract (FRT) through direct, rapid, aerosol exposure of the FRT epithelium to naked mRNA in water, and when combined with antibody engineering, should allow for rapid expression, and controllable persistence of the protective antibodies in tissues and secretions. Overall this approach represents a new paradigm for HIV prevention, one that can be extended and combined with the co-expression of other anti-sexually transmitted infection antibodies, such as those against HSV-2.

PI_NAMEs: SANTANGELO, PHILIP J (contact);VILLINGER, FRANCOIS J

PROGRAM_OFFICER_NAME: BOGGIANO, CESAR AUGUSTO

PROJECT_TERMS: Adherence;Aerosols;Affect;AIDS prevention;Anti-HIV Agents;Antibodies;antibody engineering;Bispecific Antibodies;Cells;Cervical;cost effective;Data;design;Developed Countries;Development;Devices;Dose;Drug Kinetics;Drug or chemical Tissue Distribution;Epithelium;Explosion;Female;female reproductive tract;fighting;Future;Goals;Heterosexuals;HIV;HIV Antibodies;HIV Infections;Human;Human Herpesvirus 2;Immunity;Immunoglobulin A;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;In Vitro;in vivo;Individual;Infection;Infection prevention;Inflammation;Interruption;Kinetics;Lesion;Link;Local Microbicides;Longevity;Macaca;Macaca mulatta;Measures;Mediating;Membrane;Messenger RNA;Methods;microbicide;Modeling;Monoclonal Antibodies;mRNA delivery;mRNA Expression;Mucous Membrane;Mus;neutralizing antibody;novel strategies;pathogenic bacteria;Patients;Peptide Hydrolases;Pharmaceutical Preparations;pre-clinical;pre-exposure prophylaxis;prevent;Prevention;Prevention Measures;Production;protective efficacy;Protocols documentation;reproductive hormone;Resistance;Resource-limited setting;Respiratory syncytial virus;Schedule;Sexually Transmitted Diseases;Sheep;side effect;simian human immunodeficiency virus;social stigma;Surface;Testing;Therapeutic;Time;Tissues;Topical application;Transfection;transmission process;uptake;Vaccines;Vagina;Viral reservoir;Virus;Water;Woman

PROJECT_TITLE: Durable Vaginal Protection from HIV via mRNA expression of BNABS

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Cancer;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: SURGERY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative The Rutgers Youth Enjoy Science project is relevant to public health because it will develop a more diverse biomedical, cancer research and healthcare workforce to reduce cancer health disparities in New Jersey and nationally. This project at the Rutgers Cancer Institute of New Jersey will train, motivate and support students from underrepresented groups to pursue biomedical, cancer research careers. High school and undergraduate students will engage in mentored hands-on research experience, co-curricular and professional career development activities and their science teachers will be provided with mentored research experience and curriculum development support. Innovative outreach activities will connect program participants with schools and families in their communities to enhance awareness and appreciation of science education and research careers.

PI_NAMEs: CHAUDHARY, SUNITA  (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Address;anti-cancer research;Awareness;Back;Behavioral;Black Populations;Cancer Burden;cancer health disparity;Cancer Institute of New Jersey;cancer prevention;career;career development;Clinical;cohort;Collaborations;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;curriculum development;Development;Disparity population;Education;Education and Outreach;Educational Background;Elements;Ensure;Environment;ethnic minority;Evaluation;Event;experience;Faculty;faculty mentor;Family;Funding;Goals;hands on research;health inequalities;Healthcare;high school;High School Faculty;Hispanic Populations;Individual;Inequity;innovation;Instruction;Interdisciplinary Study;interest;Journals;junior high school;Knowledge;Lead;Leadership;Malignant Neoplasms;member;Mentors;Middle School Student;New Jersey;next generation;novel;Outcome;outreach;Parents;Participant;peer coaching;Peer Review;population based;Population Group;prevent;Prevention strategy;programs;Public Health;Publishing;racial minority;recruit;Research;research and development;Research Support;Research Training;Resources;school district;Schools;Science;science education;science teacher;Science, Technology, Engineering and Mathematics Education;skills;socioeconomics;student training;Students;symposium;synergism;teacher;Teacher Professional Development;Touch sensation;Training;training opportunity;undergraduate student;Underrepresented Populations;Underrepresented Students;web site;Youth

PROJECT_TITLE: Rutgers Youth Enjoy Science (RUYES) program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Lewy Body Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE This grant is focused on the development of a novel higher order interpretable deep convolutional neural network called VolterraNet for automated classiﬁcation of multi-modality magnetic resonance images (MRI) (structural and diffusion MRI) acquired from individuals with Lewy Body diseases and Alzheimers disease respectively. The VolterraNet will be tested on a cohort of 1167 brain dMRIs from individuals with Lewy body diseases and Alzheimers disease.

PI_NAMEs: VEMURI, BABA C (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Architecture;Atrophic;Biological Markers;Brain;Brain region;Brain scan;Classification;Clinical;clinical diagnosis;cohort;Communities;Complex;Computer Vision Systems;Consensus;Consult;Control Groups;convolutional neural network;coping;Counseling;Country;Data;Data Sources;data space;deep learning;deep neural network;Dementia;Dementia with Lewy Bodies;design;Detection;detection method;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Imaging;Differential Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;diffusion weighted;Discrimination;Disease;Euclidean Space;Exhibits;Fiber;Geometry;Goals;Grant;Image;imaging approach;Imaging Techniques;improved;Individual;Lead;Learning;learning network;Lewy Body Dementia;Lewy Body Disease;Literature;Magnetic Resonance Imaging;mathematical model;Measures;Medical Imaging;Methods;Modeling;MRI Scans;multimodal data;multimodality;Nationalities;Neurodegenerative Disorders;Neurologist;Neurology;neurorestoration;novel;Parkinson Disease;Patients;Population;programs;progression marker;rapid diagnosis;Research;Research Priority;Resolution;Sampling;Scanning;Selection Bias;Sensitivity and Specificity;Series;Signal Transduction;Site;Specialist;Statistical Methods;success;Symptoms;Techniques;Testing;Time;Tissues;Validation;vector;Work;Writing

PROJECT_TITLE: Higher Order Convolutional Neural Network for Classification of Lewy-body Diseases and Alzheimers Disease

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: Blast-mediated traumatic brain injury {TBI} is a leading cause of injury for Veterans. Our central hypothesis is that changes in retinal function and changes in protein expression in the blood are predictive of chronic neuronal dysfunction in the brain. We will developing provocative tests of the retina and additionally evaluate peri-acute and chronic protein biomarkers in order to identify individuals with sub-chronic blast phenotypes. We will also investigate a molecular pathway we have determined to be involved in visual loss following blast exposure. This proposal will generate the data necessary to identify individuals at risk for chronic neurodegeneration as a consequence of blast exposure, and also for the development of therapies that will prevent vision loss in Veterans and improve their quality of life.

PI_NAMEs: HARPER, MATTHEW M. (contact)

PROJECT_TERMS: blood-based biomarker;Pathology;Visual

PROJECT_TITLE: BCCMA: Predicting TBI Pathology with Visual and Blood-based Biomarkers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURF-C (01)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Difficulty walking and cognitive impairment are common in aging and often associated with changes on brain imaging, but not everyone is afflicted equally. We propose to identify what brain imaging features distinguishes those who age with and without disability. Our findings will inform us about ways to maintain healthy brain aging and prevent dementia and falls.

PI_NAMEs: SOROND, FARZANEH A (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acceleration;Affect;African American population;African Women;Age;age related;aged;Aging;aging brain;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Award;Basal Ganglia;Blood Pressure;Blood Vessels;Brain;brain health;Brain imaging;brain magnetic resonance imaging;Cerebrum;Clinical;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive performance;cognitive testing;cohort;Cohort Studies;Coronary Artery Risk Development in Young Adults Study;Data;data warehouse;Dementia;Diffusion;disability;epidemiologic data;Epidemiology;executive function;falls;Future;Gait;Gait abnormality;health disparity populations;Healthcare;Healthcare Systems;high risk;human old age (65+);Image;Impaired cognition;Individual;late life;life span;Link;Magnetic Resonance Imaging;Measures;Mediating;middle age;Mobility decline;morphometry;Motor;Nervous System Disorder;neuroimaging;Older Population;Patients;preservation;prevent;progression risk;promote resilience;Property;Publications;Publishing;recruit;resilience;resilience biomarker;Rest;Risk;Testing;Thalamic structure;therapeutic development;Universities;Vascular Dementia;vascular risk factor;white matter;White Matter Hyperintensity;Work;young adult

PROJECT_TITLE: Cerebral Small Vessels in Motor and Cognitive Decline: Neuroimaging Signatures of Vulnerability & Resilience

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ORG_CITY: AUGUSTA

ORG_NAME: CHARLIE NORWOOD VA MEDICAL CENTER

PHR: In the US, 1.5 million people are affected by sepsis, with a mortality of more than 250,000 annually. There is no effective treatment for sepsis, which is a major healthcare issue among the Veterans. Every year over 35,000 Veterans are hospitalized with sepsis. A high rate of post- sepsis readmission, post-sepsis mortality, and significant increases in healthcare facility use are reported among Veterans surviving sepsis. A number of immunomodulatory therapies that targeted sepsis were not successful in clinical trials. Our focus on bioenergetic modulation provides an alternative approach in sepsis treatmentOur studies, if successful, will result in the identification and preclinical confirmation of BACH1 as a molecular target in reducing or preventing mortality following sepsis, and identify possible mechanisms by which Bach1 deficiency is related to improved outcome.

PI_NAMEs: RAJU, RAGHAVAN PILLAI (contact)

PROJECT_TERMS: Affect;Antioxidants;BACH1 gene;Binding;Bioenergetics;Biogenesis;biological adaptation to stress;cecal ligation puncture;cell injury;Cessation of life;Characteristics;ChIP-seq;Clinical Trials;Complex;Data;Disease;effective therapy;Enhancers;Equilibrium;experience;Functional disorder;Gene Expression;Genes;Health care facility;Health system;Healthcare;Heme;Homeostasis;hospital readmission;Hospitalization;Hypoxia;Immune;Immune response;immunomodulatory therapies;improved;improved outcome;In Vitro;in vivo;Infection;Injury;Knowledge;Link;Liver;liver injury;Liver Mitochondria;Mediating;Mediator;Metabolic;Metabolism;Methods;Microcirculation;Mission;Mitochondria;mitochondrial dysfunction;Molecular Target;mortality;Mus;novel;Nuclear;Organ;organ injury;Outcome;Outcomes Research;Oxidative Stress;Perfusion;Persons;Play;polymicrobial sepsis;pre-clinical;prevent;promoter;Proteins;Quality Control;Regulation;Reporting;Research;response;Role;Sepsis;targeted treatment;Techniques;Testing;therapeutic target;Tissues;transcription factor;treatment strategy;United States;United States Department of Veterans Affairs;Veterans;Veterans Health Administration

PROJECT_TITLE: Bach1 as a molecular target in sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 SURG-R (01)]


PHR: HLA class-II genes and gut microbiota had emerged as an important genetic and environmental factor linked with the pathobiology of multiple sclerosis (MS) a relevant medical problem faced by Veterans. However, the mechanism through which interaction between gene (HLA class-II) and environmental factor (microbiota) might predispose to or protect form MS is unknown. Thus, our proposal on understanding the mechanisms through which the HLA and gut microbiota can modulate disease in MS patients will be an essential step in that direction as a better understanding of the same might lead to discovery of novel treatment options.

PI_NAMEs: MANGALAM, ASHUTOSH KUMAR (contact)

PROJECT_TERMS: Adult;Affect;Alleles;Animal Model;Antibiotics;Autoimmune Diseases;Bacteria;CD4 Positive T Lymphocytes;Cell Physiology;Central Nervous System Diseases;chronic inflammatory disease;cytokine;Data;Dependence;Development;Diagnostic;Disease;Disease Outcome;disease phenotype;Disease Resistance;Disease susceptibility;dysbiosis;effector T cell;Environmental Risk Factor;Experimental Autoimmune Encephalomyelitis;Fostering;Frequencies;Genes;Genetic;Genetic Polymorphism;Germ-Free;Goals;gut bacteria;gut dysbiosis;gut microbiome;gut microbiota;HLA-DQ8 antigen;HLA-DR Antigens;HLA-DR3 Antigen;Homeostasis;host microbiome;host microbiota;Human;Human body;IL17 gene;Immune;Immune response;Immune System Diseases;Immunity;immunoregulation;imprint;Inflammatory;Lactation;Life;Link;Mammals;Medical;MHC Class II Genes;microbiome;microbiome analysis;microbiome research;microbiota;microbiota profiles;microbiota transplantation;Multiple Sclerosis;multiple sclerosis patient;Mus;Neonatal;Newborn Infant;novel;novel diagnostics;pathobiont;Pathogenesis;Pathogenicity;Pathologic;Persons;Play;Predisposition;prognostic;pup;Reaction;Regulation;Regulatory T-Lymphocyte;Resistance;resistant strain;response;Role;Severities;Shapes;symbiont;Symbiosis;Therapeutic Agents;therapeutic target;Transgenic Mice;translational potential;Veterans;Weaning

PROJECT_TITLE: Role of HLA Class-II Polymorphism in the Regulation of Host-Microbiota Symbiosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 IMMA-G (01)]


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: PTSD is a prevalent condition for which veterans frequently seek treatment in the VA healthcare system. Although there are several first-line PTSD treatments available, at least one third of veterans drop out prematurely from these treatments. Further, VA mental health treatment providers have noted numerous systemic barriers to implementing these treatments with their veteran clients. These problems underscore the need to identify alternative, evidence-based treatments that address both patient and provider concerns. Written Exposure Therapy (WET) may be such a treatment. If WET is found efficaciously treat veterans with PTSD, then VA would have a brief and well-tolerated PTSD treatment option for use with veterans.

PI_NAMEs: SLOAN, DENISE M. (contact)

PROJECT_TERMS: Address;Age;brief intervention;Client;Clinic;Clinical Practice Guideline;Clinical Services;Cognitive;combat;Data;Diagnosis;Dropout;Drops;evidence base;Evidence based treatment;Goals;Health Personnel;Healthcare Systems;men;Mental Depression;Mental Health;Mental Health Services;Patients;Post-Traumatic Stress Disorders;Practice Guidelines;premature;primary outcome;Provider;Psychotherapy;Randomized;randomized trial;randomized, clinical trials;Recommendation;Research;Resources;Sampling;Severities;sex;Social support;Survivors;Symptoms;systemic barrier;Testing;Time;Training;Trauma;treatment effect;Treatment outcome;Veterans;Woman;Writing

PROJECT_TITLE: An efficient, exposure-based treatment for PTSD compared to Prolonged Exposure: A non-inferiority randomized trial


NIH_SPENDING_CATS: Biotechnology;Bipolar Disorder;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative / Relevance Severe psychiatric disorders cause enormous human suffering, costs, and risk of death. Although we have learned a lot about the genetic causes, we urgently need to pinpoint many more specific genes. This new knowledge will inform the development of new therapies.

PI_NAMEs: SULLIVAN, PATRICK F (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Africa;Americas;Asia;Biological Assay;Bipolar I;Clinical;Code;Collaborations;Consent;Contracts;cost;Data;data archive;Data Set;data sharing;Deposition;Development;Diagnosis;Diagnostic;Direct Costs;Disease;DNA;Educational process of instructing;Ethics;Etiology;Europe;exome;exome sequencing;Far East;Funding;gene discovery;Genes;Genetic;genetic architecture;Genetic Variation;genome wide association study;genomic variation;Genomics;Genotype;Human;Individual;insertion/deletion mutation;Knowledge;Learning;low income country;Major Depressive Disorder;Manic;Measures;Mental disorders;Meta-Analysis;Methods;Moon;mortality risk;National Institute of Mental Health;novel;novel therapeutics;Occupations;Output;Paper;Patients;Phase;Phenotype;Policies;Population Heterogeneity;Process;programs;psychiatric genomics;Psychiatry;Psychoses;Research;Research Personnel;Resource Sharing;risk variant;Role;Sample Size;Sampling;Schizoaffective Disorders;Schizophrenia;Science;secondary analysis;severe mental illness;severe psychiatric disorder;Severities;Site;SNP array;Technology;Therapeutic;therapy resistant;Training;Trans-Omics for Precision Medicine;Travel;Variant;Work

PROJECT_TITLE: 1/3 Sequencing and Trans-Diagnostic Phenotyping of Severe Mental Illness in Diverse Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(60)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Networking and Information Technology R&D (NITRD);Palliative Care;Patient Safety;Pediatric;Pediatric Cancer;Rare Diseases

PHR: Project Narrative This study will evaluate the effectiveness of the Symptom Monitoring & Systematic Assessment and Reporting System in Young Survivors program (SyMon-SAYS) for children with cancer in decreasing patients’ symptom burden, decreasing parent-perceived barriers in managing their child’s symptoms, increasing patients’ and parents’ self-efficacy and increasing patients’ quality of life. We will also examine influential variables impacting the effectiveness of the SyMon-SAYS program.

PI_NAMEs: LAI, JIN-SHEI  (contact)

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: Adherence;Age;Ambulatory Care;burden of illness;cancer care;Cancer Patient;cancer therapy;care outcomes;Caregivers;Caring;Child;Clinic;Clinic Visits;Clinical;clinical care;Communication;design;Disease;Effectiveness;effectiveness evaluation;Electronic Health Record;electronic health record system;experience;Family;Fatigue;feasibility testing;Feedback;Goals;handbook;Health;health literacy;health related quality of life;Healthcare;improved;improved outcome;Individual;Influentials;Information Management;Information Technology;Institution;interest;Intervention;Learning;life span;Logistic Regressions;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical Records;medical specialist;Modeling;Monitor;Notification;Outcome;Pamphlets;Parents;patient engagement;patient oriented;Patient Outcomes Assessments;patient portal;Patient-Centered Care;Patients;Pediatric Oncology;Pediatric Oncology Group;Physicians;Pilot Projects;Positioning Attribute;preference;Process;programs;prototype;Provider;psychosocial;Quality of life;random forest;Randomized, Controlled Trials;Reporting;response;Role;Schedule;Self Efficacy;Self Management;Severity of illness;side effect;skills;Survivors;survivorship;Symptom Burden;symptom management;Symptoms;System;Time;transition to adulthood;treatment as usual;treatment planning;usability;Visit;Waiting Lists

PROJECT_TITLE: Using Information Technology to Improve Outcomes for Children Living with Cancer


NIH_SPENDING_CATS: Biotechnology;Bipolar Disorder;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: CARDIFF

ORG_NAME: CARDIFF UNIVERSITY

ORG_ZIPCODE: CF24 0DE

PI_NAMEs: ESCOTT-PRICE, VALENTINA ;O'DONOVAN, MICHAEL ;OWEN, MICHAEL JOHN;WALTERS, JAMES TYNAN RHYS (contact)

PROJECT_TITLE: 3/3 Sequencing and Trans-Diagnostic Phenotyping of Severe Mental Illness in Diverse Populations