NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

PHR: Project Narrative DNA damage in cancer cells can activate nucleic acid sensing pathways that regulate both anti- and pro-tumor immune responses. The central goal is to understand the immune basis of these contrasting effects. The findings will provide a foundation for rationally targeting these pathways in cancer immunotherapy.

PI_NAMEs: HALDAR, MALAY  (contact)

PROJECT_TERMS: Acute;anti-tumor immune response;Antigen-Presenting Cells;antitumor effect;Biological Response Modifiers;Biology;BRCA2 gene;cancer cell;cancer immunotherapy;Cancer Model;cancer therapy;CASP1 gene;CD47 gene;Cell Line;cell transformation;cell type;Cells;Chemicals;chemotherapy;Chromosomal Instability;Chronic;Collaborations;Combination immunotherapy;combinatorial;Cyclic AMP;cytokine;Data;defined contribution;Dendritic Cells;Development;dimensional analysis;DNA;DNA Damage;DNA Repair;Equilibrium;Evaluation;Foundations;Future;Genes;Genetic;Genomic Instability;GMP synthase;Goals;high dimensionality;IL18 gene;Immune;immune checkpoint blockade;Immune Evasion;Immune response;Immunity;Immunosuppression;Immunotherapeutic agent;Impairment;implantation;in vivo;Inflammasome;Inflammatory Response;insight;Interferon Type I;Interferons;Interleukin-1;Interleukin-1 beta;Knowledge;Lead;Leucocytic infiltrate;Macrophage;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Membrane Proteins;Modeling;Mutation;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Nucleic Acids;Outcome;pathogen;Pathway interactions;Pattern recognition receptor;Phagocytes;Phagocytosis;pharmacologic;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Process;Radiation;Radiation therapy;receptor;recruit;Regulation;response;RNA;Role;sensor;Serous;Signal Transduction;Solid Neoplasm;Stimulator of Interferon Genes;synergism;T cell response;T-Lymphocyte;Testing;Time;tool;Tretinoin;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;Work

PROJECT_TITLE: Delineating how nucleic acid sensing in tumorcells regulate anti-tumor immune responses


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: OKLAHOMA CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: OVERALL: PROJECT NARRATIVE The OU Stephenson Cancer Center fulfills a unique need in Oklahoma and the region by conducting innovative and impactful research that seeks to translate novel discoveries into the clinical or community setting through a transdisciplinary team-based approach. The goal of these efforts is to decrease cancer incidence and improve outcomes for Oklahomans and all individuals, with a special emphasis on promoting cancer health equity among the state’s underserved minority populations.

PI_NAMEs: MANNEL, ROBERT S. (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Address;African American;American Indian Tribe;American Indians;Biomedical Research;Black race;cancer care;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;Catchment Area;Clinical;Clinical Trials;Collaborations;Colon Carcinoma;Communities;Community Outreach;community setting;design;Disparity;Education;Ensure;Faculty;Fostering;Funding;Goals;Grant;Growth;Health;health equity;health equity promotion;Health Professional;Health Technology;improved outcome;Incidence;Individual;Infrastructure;innovation;Intervention;Investments;Leadership;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;member;Mentorship;mHealth;Minority Groups;Mission;morphogens;mortality;multidisciplinary;NCI-Designated Cancer Center;next generation;novel;Oklahoma;Oncology;outreach;patient oriented;Persons;Population;Positioning Attribute;programs;Publications;recruit;Reporting;Research;Research Activity;Research Peer Review;Resources;Rural Population;Science;Site;social health determinants;Strategic Planning;Students;Therapeutic;tobacco control;Training;Training Activity;Translating;Translations;underserved minority;United States National Institutes of Health;Universities;Vision;Vulnerable Populations;Woman

PROJECT_TITLE: Stephenson Cancer Center - Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: WILLIAMS, WADE  (contact)

PROJECT_TERMS: Annual Reports;Applications Grants;Award;Cancer Center;Cancer Center Support Grant;cancer research center director;career;Clinical Trials;Collaborations;community engagement;Community Outreach;Component of the Center for Cancer Research;cost effective;COVID-19;Data;Data Management Resources;Decision Making;Development;Direct Costs;Doctor of Philosophy;Education;Endowment;Ensure;equity, diversity, and inclusion;Evaluation;Event;experience;Extramural Activities;Faculty Recruitment;Funding;Goals;Grant;Group Meetings;Infrastructure;Leadership;meetings;member;Mission;Monitor;NCI Center for Cancer Research;Office of Administrative Management;Oklahoma;Oncology;Outcome;Peer Review;Persons;Policies;Preparation;Process;programs;Protocols documentation;recruit;Reporting;Research;Research Activity;research faculty;Research Peer Review;Research Personnel;Research Support;Resource Sharing;Resources;Science;Services;Strategic Planning;Structure;System;Tobacco;Training;Trust;Update;virtual;working group;Workplace;Writing

PROJECT_TITLE: Administrative Core


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative The major goal for The Administrative Core A will be to facilitate the research activities of this Program Project, thereby enabling Program members to focus on scientific progress. As the Principal Investigator and Core A Director, Dr. Greenberg will take primary responsibility of this Core’s functions, which includes providing direction for Mrs. Murillo. In this role, Dr. Greenberg will meet frequently with the Project and Core leaders to jointly discuss the overall direction of the research.

PI_NAMEs: GREENBERG, ROGER A (contact)

PROJECT_TERMS: Accounting;Administrator;Air;anti-tumor immune response;Artificial Mammalian Chromosomes;Biology;Books;Budgets;Businesses;Cancer Biology;Certification;Chemicals;Communication;Critiques;Data Analyses;data sharing;Electronic Mail;Ensure;experience;Funding;genome integrity;Genomic Instability;Goals;Grant;Guidelines;Human Resources;Institution;International;Laboratories;Manuscripts;meetings;member;Monitor;National Cancer Institute;Occupational activity of managing finances;Pennsylvania;Persons;Policies;Preparation;Principal Investigator;programs;Progress Reports;Reporting;Research;Research Activity;Research Personnel;Resources;Role;Sampling;Schedule;Services;Structure;Telephone;Travel;United States National Institutes of Health;Universities;Videoconferencing;virtual;Work

PROJECT_TITLE: Admin Core A


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: ___________________ _ ____ ____PROJECT NARRATIVE ___ __ ____ __ __ _____________ The Pharmacological Sciences Training Program (PSTP) at the University of Iowa is an interdisciplinary training program with a goal of training a diverse cohort of Ph.D. students in the pharmacological sciences in order to prepare them for research and research-related careers. We provide our students with foundational and in- depth knowledge of pharmacology as well as hands-on training in cutting-edge research. Rigor and reproducibility, critical self-assessment, and dedication to mentoring of students and faculty at all levels are threads woven throughout our program.

PI_NAMEs: ROMAN, DAVID L.;STRACK, STEFAN  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TITLE: Predoctoral Training in the Pharmacological Sciences

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


PHR: There is a dire need in cancer biology to advance the understanding of the downstream consequences of DNA damage, the causes and consequences of chromosome missegreation at cell division, and the mechanisms that drive these processes in tumors. The mammalian artificial chromosome (MAC) core will serve as a foundry for the advanced genetic tools that are uniquely suited for studies of these processes. The MACs will serve as critical tools for developing new understanding that has the promise to impact immune modulating approaches that improve patient response, inform new strategies to overcome therapeutic resistance, and develop predictive biomarkers of patient response.

PI_NAMEs: BLACK, BEN E. (contact)

PROJECT_TERMS: Address;Animals;anti-tumor immune response;Artificial Human Chromosomes;Artificial Mammalian Chromosomes;Award;Biology;Cancer Biology;Categories;Cell Cycle;Cell division;cell type;Cells;Centromere;chemical genetics;Chemicals;Chromatin;Chromatin Modeling;chromosome missegregation;Chromosome Segregation;Chromosomes;Cloning;Cytoplasm;design;design and construction;DNA;DNA cassette;DNA Damage;DNA Sequence;DNA sequencing;embryonic stem cell;Engineered Gene;Engineering;Epigenetic Process;epigenomics;Essential Genes;Event;experimental study;falls;flexibility;Gene Dosage;Generations;Genes;Genetic;genetic information;genetic payload;Genetic Recombination;Genome;Genomic Instability;genomic locus;Genomics;Housing;Human Genome;immunoregulation;improved;Individual;Inherited;innovation;Lead;member;micronucleus;Mitosis;Mitotic;Mitotic Chromosome;Molecular;Molecular Biology;Monitor;Mus;Nature;next generation;Organoids;Outcome;patient response;predictive marker;Process;programs;Proteins;Regulatory Element;Reporter;Reporting;response;Saccharomycetales;segregation;Sister Chromatid;Site;synthetic biology;System;Technology;therapy resistant;tool;tumor;Work

PROJECT_TITLE: Core 2: Mammalian Artificial Chromosome (MAC)


NIH_SPENDING_CATS: Cancer;Clinical Research

PI_NAMEs: RAMESH, RAJAGOPAL  (contact)

PROJECT_TERMS: American Cancer Society;anti-cancer research;Award;Cancer Center;Cancer Center Support Grant;cancer imaging;career;career development;Catchment Area;Centers of Research Excellence;Clinical;community engagement;Community Outreach;Direct Costs;Doctor of Philosophy;Education;equity, diversity, and inclusion;Faculty;Funding;Goals;Grant;Health Professional;high school;high school program;Infrastructure;Institution;Investments;K-Series Research Career Programs;Leadership;Malignant Neoplasms;member;Mentors;Mentorship;Minority;Minority Groups;Mission;Native American Research Center for Health;NCI Center for Cancer Research;NCI-Designated Cancer Center;next generation;Oklahoma;Oncology;Pathway interactions;Peer Review;Persons;Play;Postdoctoral Fellow;Program Development;programs;Reporting;Research;Research Personnel;Research Project Grants;Resources;Role;Students;summer internship;summer research;summer student;Training;Training and Education;training project;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Cancer Research Training and Education Coordination


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE To treat disorders such as autism, schizophrenia, and epilepsy we must understand the mechanisms that govern how neural circuits are built during development. Neurons differentiate into several unique subtypes which must interact to assemble healthy cortical circuits. Here, we will knock out the disease-risk gene Satb2 from excitatory pyramidal cells to determine how this impacts their differentiation into distinct neuronal types, and in turn the development of the neural circuits of the hippocampus.

PI_NAMEs: WESTER, JASON C. (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Acute;Adolescent;Adult;Architecture;Area;ATAC-seq;autism spectrum disorder;autistic behaviour;Birth;Brain;Brain region;Cell Differentiation process;Cells;Chromatin;chromatin remodeling;Chromatin Structure;Classification;conditional knockout;craniofacial;Data;Development;Developmental Delay Disorders;Disease;disorder risk;Electric Stimulation;Electrophysiology (science);Embryo;entorhinal cortex;environmental enrichment for laboratory animals;Epigenetic Process;epigenetic regulation;Epilepsy;Exhibits;experience;Experimental Designs;experimental study;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;Health;Hippocampus;Human;human disease;Impairment;Inhibitory Synapse;insight;Intellectual functioning disability;Interneurons;Knock-out;Knowledge;Learning;Location;Long-Term Potentiation;Maintenance;Maps;Mediating;Membrane;Memory;memory consolidation;migration;Modification;Molecular;Molecular Genetics;Molecular Profiling;Morphology;Mus;Mutant Strains Mice;Mutation;neocortical;neural;neural circuit;neurodevelopment;neuron development;Neuronal Differentiation;Neurons;novel strategies;Osteoblasts;Output;Physiology;Play;Positioning Attribute;postnatal development;Process;Property;Proteins;Pyramidal Cells;Radial;recruit;Regulatory Pathway;response;risk variant;Role;Schizophrenia;Series;single-cell RNA sequencing;Slice;Source;Specific qualifier value;Structure;Synapses;Synaptic plasticity;Techniques;Testing;Time;Tissue-Specific Gene Expression;tool;Transcriptional Regulation;Whole-Cell Recordings;Work

PROJECT_TITLE: Development of neuronal subtypes and local circuits in the hippocampus

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: WALKER, JOAN LESLIE (contact)

PROJECT_TERMS: Address;African American;anti-cancer research;Black race;Cancer Center;Cancer Center Support Grant;cancer research center director;career;Catchment Area;Communities;Complex;Creativeness;Doctor of Philosophy;Education;educational atmosphere;Environment;Equity;equity, diversity, and inclusion;Evaluation;Faculty;Fostering;Grant;Health Benefit;health disparity populations;health equity;improved;Individual;Infrastructure;innovation;Institution;Leadership;Life Experience;member;Mentors;Minority;Minority Groups;Peer Review;Population;Positioning Attribute;Process;programs;public trust;recruit;Reporting;Research;Research Personnel;Resources;Role;Scientist;Strategic Planning;success;Underrepresented Minority;Woman

PROJECT_TITLE: Plan for Enhancing Diversity


PHR: Project Narrative Chemical Biology tools for probing, manipulating, and imaging biological systems can provide deep insights into fundamental processes. Protein chemical dimerization tools, peptide chemical tools, and small molecule agonist/antagonist chemical tools are critical to key project Aims in this P01. The Chemical Biology and Materials Core will work directly with the individual projects in this program to design, synthesize, and implement cutting edge Chemical biology tools customized to the project research aims.

PI_NAMEs: CHENOWETH, DAVID MICHAEL (contact)

PROJECT_TERMS: Agonist;antagonist;anti-tumor immune response;Award;Biological;Biological Process;biological systems;Biology;cancer cell;CD47 gene;Cell Physiology;Cells;Chemicals;Chromosomal Instability;Collaborations;Collagen;Complex;design;Detection;Development;Dimerization;Environment;Event;Fluorescent Probes;genetic approach;genetic regulatory protein;genome integrity;Genomic Instability;Gibberellins;Glean;Goals;Hybrids;Image;Individual;innovation;insight;Laboratories;live cell imaging;Macrophage;Meiosis;Membrane;Mitosis;Molecular;Monitor;Natural Products;novel strategies;nucleic acid structure;Nucleic Acids;Optics;optogenetics;Pathway interactions;Peptides;peptidomimetics;Process;programs;protein aggregation;Proteins;Reagent;Reporting;Research;Research Project Grants;Resources;sensor;Sirolimus;small molecule;Structure;synergism;System;Technology;Time;tool;trafficking;Variant;Whole Organism;Work

PROJECT_TITLE: Core 3: Chemical Biology & Materials Tools (CBMT)


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Intellectual and Developmental Disabilities (IDD);Pediatric;Physical Activity;Prevention;Rehabilitation

ORG_CITY: CORVALLIS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The proposed research will improve our understanding of a ‘one health’ approach to physical activity interventions for adolescents with developmental disabilities through the multi-site evaluation of a novel, imitation-based, intervention with the family dog. This intervention is designed to increase daily physical activity, quality of life and social wellbeing in adolescents with developmental disabilities, even after the program has been completed. This research will improve public health by evaluating new areas of animal assisted intervention aimed at improved developmental trajectories for adolescents with developmental disabilities, directly addressing the research goals of the One Health initiative.

PI_NAMEs: MACDONALD, MEGAN I (contact);UDELL, MONIQUE A

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: active lifestyle;Address;Adherence;Adolescent;Adult;Age;Animal Testing Alternatives;animal-assisted therapy;Animals;Area;Behavior;Behavioral;behavioral response;Canis familiaris;Caregivers;Child;Child Welfare;Cues;depressive symptoms;design;Development;Developmental Disabilities;disability;Dog family;early adolescence;Educational Intervention;Educational process of instructing;Emotional;Evaluation;exercise intervention;expectation;experience;Family;feasibility testing;Feeling;Fostering;Goals;Health;Hearing;Home;Human;improved;Inequity;innovation;interdisciplinary approach;Intervention;Joints;Knowledge;learned behavior;Measures;Methodology;middle childhood;Morale;multidisciplinary;novel;Operant Conditioning;Outcome;Ownership;Parents;Participant;peer;Personal Satisfaction;Physical activity;physical inactivity;Population;programs;Protocols documentation;psychological symptom;Public Health;Quality of life;Randomized, Controlled Trials;Relaxation;Research;Research Personnel;Research Support;Secure;Service animal;Siblings;Site;skills;social;Social Behavior;social skills;Social support;Social Well-Being;Supervision;Testing;Therapeutic;Training;Training Programs;verbal;Waiting Lists;Walking;Work

PROJECT_TITLE: The evaluation of a multi-site novel imitation based animal assisted intervention for children with developmental disabilities and their family dog


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Prevention;Rare Diseases;Women's Health Research

PI_NAMEs: BHATTACHARYA, RESHAM  (contact)

PROJECT_TERMS: Adipose tissue;Advanced Malignant Neoplasm;Affect;angiogenesis;Apoptosis;Area;Attention;Basic Science;BMI1 gene;Cachexia;Cancer Biology;Cancer Burden;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer drug resistance;cancer initiation;cancer prevention;Cancer Research Project;cancer therapy;Catchment Area;Cell Cycle;cell growth;cell stroma;Chemoresistance;Clinical Trials;Collaborations;Colon;community engagement;Community Outreach;Diagnosis;Direct Costs;Doctor of Philosophy;Epithelial Cells;ERBB2 gene;Event;Evolution;Fostering;Funding;Goals;Growth Factor;insight;Institution;interest;Investigation;Journals;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammary Neoplasms;Mediating;meetings;member;microbiome;Molecular;Muscular Atrophy;Mutation;Neoplasm Metastasis;neoplastic cell;Normal Cell;Obesity;Oklahoma;Oncogenes;Oncogenic;Peer Review;pre-clinical;programs;Publications;Publishing;Reporting;Research;Research Peer Review;resistance mechanism;Role;Science;Serous;Signal Pathway;Signal Transduction;Signaling Molecule;stem-like cell;Therapeutic;Training;Translating;translational cancer research;tumor;tumor microenvironment;tumor progression;Tumor Suppressor Genes

PROJECT_TITLE: Cancer Biology Program


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARATIVE The outer membrane of gram-negative bacteria is an impediment to the entry of antibiotics into the cell, which is especially problematic given the increasing threat of antibiotic resistance in gram-negative bacteria to public health. Our project investigates a novel link we have discovered between loss of the DNA mismatch repair pathway (MMR) and alteration of OM permeability causing broad antibiotic resistance. Completion of our Aims will elucidate the connections between MMR and OM permeability, greatly expanding our understanding of the links between DNA repair and antibiotic resistance and identifying potential targets for antimicrobial discovery.

PI_NAMEs: MITCHELL, ANGELA MARIE (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;bacterial genetics;bile salts;biological adaptation to stress;Biological Assay;Biology;cell envelope;Cell Membrane Permeability;Cells;Centers for Disease Control and Prevention (U.S.);Charge;Chemicals;Clinical;clinically relevant;cost;Data;Development;Disease;DNA;DNA Damage;DNA lesion;DNA Repair;drug discovery;Environment;Escherichia coli;Escherichia coli K12;Exclusion;experience;Exposure to;fitness;Future;Gene Expression;Genes;Genetic Transcription;Goals;Gram-Negative Bacteria;high throughput screening;Hydrophobicity;Intestines;Laboratories;Lateral;Libraries;Life;Link;Lipopolysaccharides;Membrane;Mismatch Repair;Mutagenesis;mutant;Mutation;new therapeutic target;novel;Nutrient;Osmotic Pressure;Pathway interactions;Permeability;Phospholipids;physical insult;Physiological;prevent;Probability;Public Health;Replication Error;Resistance;Resistance development;resistance mutation;resistant strain;response;Signal Pathway;Signal Transduction;small molecule;Sodium Chloride;Stress;success;Temperature;Tensile Strength;transcriptome sequencing;urgent and serious threat;Work;wound treatment

PROJECT_TITLE: A novel pathway altering OM permeability

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lead Poisoning;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: IRVINE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: This study will build upon an existing robust relationship between community-based organizations and the University of California, Irvine and use a community-based participatory research (CBPR) process to address community-defined environmental health problems on lead exposure, sources, and children’s school performance and behavioral outcomes in a socioeconomically disadvantaged community with predominately Latina/o residents in Orange County, California. The study will also develop, disseminate, pilot, and evaluate a multi-level (e.g. household, school, neighborhood, city, county) Public Health Equity Action Plan, with a focus on equity and the ultimate goal of improving child academic and neurodevelopmental outcomes.

PI_NAMEs: FLORES, PATRICIA ;LEBRON, ALANA M.W.;WU, JUN  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 10 year old;Address;Affect;Age;Age Months;Aggressive behavior;anxious;Attention;Awareness;Behavior;behavioral outcome;Binding;Biological Markers;Black race;Blood;blood lead;California;Censuses;Child;Child Behavior;Child Behavior Checklist;Child Development;Child Health;Child Support;Childhood;childhood nervous system lead poisoning;Chronic;chronic Pb exposure;Cities;Cognitive;Communities;community academic partnership;community based participatory research;community led intervention;community organizations;contextual factors;County;Data;Data Collection;deciduous tooth;Depressed mood;design;Development Plans;eighth grade;elementary school;Eligibility Determination;Enrollment;Environment;Environmental Health;Equity;Etiology;evidence base;Evidence based practice;Exposure to;Family;Fostering;Funding;Goals;Government;Health;health equity;health inequalities;Health Insurance;Household;Immigrant;implementation science;improved;Income;Individual;Industrialization;Inequity;Information Dissemination;Insurance;Intervention;Joints;kindergarten;Knowledge;Latina;Lead;lead exposure;Lead levels;Leadership;Legal system;Life;Life Cycle Stages;Link;Low income;Mathematics;Measurement;Measures;Metals;Modification;neighborhood disadvantage;Neighborhoods;neurobehavioral;Neurologic;Neurotoxins;Oranges;Outcome;Outcome Measure;Outcome Study;Patient Recruitments;Performance;Policies;Population;Predisposition;Pregnancy;Prevalence;prevent;Prevention program;primary caregiver;Process;Prospective cohort;Public Health;Questionnaires;Reading;remediation;Research;Resolution;response;Risk Factors;Schools;Science;screening;Second Pregnancy Trimester;Series;Shapes;social;sociodemographic factors;socioeconomic disadvantage;Soil;soil lead;soil sampling;Source;Standardization;Strategic Planning;study population;Symptoms;Syndrome;Time;Tooth structure;Translating;Universities

PROJECT_TITLE: Inequities in Childhood Life-Course Lead Exposure and Academic and Neurobehavioral Outcomes (I-CLEAN)

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Nutrition;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Narrative: This grant proposes to elucidate how aging affects NAD+ metabolism in normal and progeroid fibroblasts as well as in mice, and if NAD+ replenishment can mitigate progeroid or senescence phenotypes. A second aspect of work characterizes the effect and metabolic pathway of a novel NAD+ precursor called dihydronicotinamide riboside (NRH) in fibroblasts and mice. Finally, pre-clinical translational studies characterize effects of NRH in eliciting mitochondrial biogenesis in aged mice and test its effects in the treatment of a mouse model of metabolic syndrome.

PI_NAMEs: YANG, YUE  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Address;Adenosine Kinase;Affect;Age;age effect;age related;age related changes;age related decline;Aging;aging process;Anabolism;Applications Grants;Biochemical Process;Biogenesis;Biological Assay;Bloom Syndrome;Body Composition;Cell model;Cells;Complex;Data;Defect;Dependence;Dermal;dihydronicotinamide;Disease;disease model;Disease Outcome;DNA Repair;DNA Repair Gene;Drug Metabolic Detoxication;Enhancers;Fibroblasts;Functional disorder;Generations;Genetic;genetic approach;Glucose Clamp;Grant;Growth;hallmarks of aging;Health;Hepatocyte;High Fat Diet;Homeostasis;Hormones;Human;improved;In Vitro;in vivo;innovation;Intervention;Investigation;Liver;Mammalian Cell;Mammals;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolic syndrome;Metabolism;metabolomics;Methods;Mitochondria;Modeling;Molecular;mouse model;Mus;next generation;novel;Nutrient;old mice;Onset of illness;Organism;Oxygen;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphotransferases;Physiological;pleiotropism;Population;pre-clinical;Predisposition;Process;repaired;Research;response;riboside;Role;self-renewal;senescence;Severity of illness;Skeletal Muscle;Somatotropin;stem cell self renewal;Testing;Time;Tissues;tool;translational potential;translational study;Treatment outcome;Werner Syndrome;Work

PROJECT_TITLE: NAD Metabolism in Aging and Disease: Dysfunction and Intervention

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Lupus;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE This project aims to establish the VGLL3-mediated, immunometabolic mechanism underlying female-biased autoimmunity. It has the potential to provide novel, pharmacologically targetable pathways for the prevention and treatment of autoimmune diseases, and guide personalized treatment of immunological diseases in order to address the sex-specific effects of drugs.

PI_NAMEs: LIANG, YUN  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Address;Affect;Autoimmune Diseases;autoimmune pathogenesis;Autoimmune Process;Autoimmunity;Binding Sites;biological adaptation to stress;Cell Death;Cells;Cellular Stress;Chromatin;chromatin immunoprecipitation;Clinical;Communicable Diseases;Complex;Cutaneous;cytokine;Data;Dependence;Deposition;Disease;disorder prevention;Disproportionately impacts women;EP300 gene;Exhibits;experimental study;Family member;Feedback;Female;FOS gene;Genetic Epistasis;high risk population;Homeostasis;Immune;Immune System Diseases;Immunity;immunoregulation;In Vitro;in vivo;Inflammatory;insight;Interferon alpha;Interferons;interleukin-17C;keratinocyte;Knowledge;Lupus;lupus-like;male;Malnutrition;Measurement;Mediating;men;Metabolic;Metabolic stress;Modeling;Molecular;Monitor;Mus;novel;Nutrient;nutrient deprivation;Nutritional;overexpression;Pathogenesis;Pathway interactions;Patients;personalized medicine;Pharmaceutical Preparations;pharmacologic;Pregnancy;Prevention;promoter;Regulation;response;Role;sex;Sex Bias;sexual dimorphism;Signal Transduction;Sjogren's Syndrome;Starvation;Stress;systemic autoimmunity;Systemic Lupus Erythematosus;Systemic Scleroderma;targeted treatment;Testing;TP53 gene;Transcriptional Activation;Up-Regulation;Woman;Women's prevalence;Work

PROJECT_TITLE: Understanding the immunometabolic mechanism of VGLL3 mediating female-biased autoimmunity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Nanotechnology

PI_NAMEs: MCNALLY, LACEY R (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Area;Artificial Intelligence;Biomedical Engineering;Biotechnology;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Detection;cancer diagnosis;Cancer Diagnostics;cancer therapy;cancer type;Catchment Area;Categories;Cessation of life;Clinical;Clinical Cancer Center;Clinical Research;Clinical Trials;Collaborations;community engagement;Community Outreach;Computational algorithm;contrast imaging;Contrast Media;Data Analyses;Death Rate;Dedications;delivery vehicle;Development;Devices;Diagnostic;diagnostic algorithm;Diagnostic Procedure;Direct Costs;Doctor of Philosophy;Drug Delivery Systems;early phase clinical trial;Fostering;fundamental research;Funding;Goals;Grant;Growth;Hematologic Neoplasms;Home;Human;Image;imaging modality;Imaging technology;improved;In Vitro;in vivo;Incidence;Infrastructure;innovation;Institution;Intervention;Journals;Laboratories;Malignant Neoplasms;Manuscripts;Medicine;member;Nanodelivery;nanoparticle;new therapeutic target;novel;novel anticancer drug;novel therapeutics;Oklahoma;Oncology;Patient-Focused Outcomes;Patients;Peer Review;Positioning Attribute;Preclinical Testing;Process;programs;Publications;Publishing;Race;Reporting;Research;Research Activity;Research Peer Review;Research Personnel;Risk;Scientist;Signal Pathway;Solid Neoplasm;success;Systems Analysis;targeted agent;Technology;Testing;Therapeutic;Therapeutic Agents;Therapeutic Clinical Trial;therapeutic evaluation;Translating;translational medicine;Translational Research;Translations;treatment trial;United States

PROJECT_TITLE: Cancer Therapeutics Program


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Consistent with the main objectives of NIDA R25s, this INSPIRE program provides a 24-month substance abuse and addictions (SAA) research mentoring program to 20 qualified scholars (5 doctoral, 15 postdoctoral/early career) primarily from AIAN populations and other Indigenous populations to facilitate careers in SAA research.

PI_NAMEs: EVANS-CAMPBELL, TERESA A (contact)

PROGRAM_OFFICER_NAME: HOLMES, ANGELA L

PROJECT_TERMS: Address;aged;Alaska Native;Alaska Native population;American Indian Population;American Indians;Americas;Applications Grants;Behavioral;behavioral health;Behavioral Research;career;Cessation of life;Classification;Clinical Skills;cohort;Contracts;Country;Dedications;design;Development;Disparity;doctoral student;editorial;Education;education research;Educational workshop;epidemiologic data;Ethnic Population;experience;Extramural Activities;falls;Funding;Generations;Grant;Great Lakes Region;health disparity;Health Promotion;Heroin;Heterogeneity;high risk;Idaho;Immersion;improved;Indigenous;Interdisciplinary Study;Learning;Manuscripts;Medicine;meetings;Mentors;Mentorship;mortality;multidisciplinary;National Institute of Drug Abuse;Native Hawaiian or Other Pacific Islander;Native-Born;next generation;Opioid;opioid epidemic;Oregon;Outcome;Overdose;Pacific Northwest;Peer Review Grants;Personal Satisfaction;Pharmaceutical Preparations;Pilot Projects;Population;Postdoctoral Fellow;Preparation;prescription opioid;Prevention;Principal Investigator;Program Development;programs;Public Health;Publishing;Qualifying;racial population;reduced substance abuse;Research;research and development;Research Institute;Research Personnel;Research Training;resilience;response;Running;Scientist;Site;Social Behavior;Structure;Substance abuse problem;Substance Addiction;success;symposium;Training;Training Programs;Travel;tribal Nation;Tribes;United States;United States National Institutes of Health;Universities;Washington;web site;webinar;Writing

PROJECT_TITLE: The Indigenous Substance abuse and addictions Prevention Interdisciplinary Research Education program- training the next generation of Native substance abuse and addictions scientists.


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: KENDZOR, DARLA ELIZABETH (contact)

PROJECT_TERMS: abuse liability;addiction;Address;African American;American Indian Population;American Indians;Area;Basic Science;Behavioral;Behavioral Sciences;Black race;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;cancer prevention;cancer risk;care coordination;Catchment Area;chemobrain;Chemopreventive Agent;Clinical Sciences;Collaborations;community based participatory research;community engagement;Community Outreach;community partnership;Complex;Continuance of life;Continuity of Patient Care;Critiques;Death Rate;Development;Disease;Disparity;DNA Damage;Doctor of Philosophy;Economically Deprived Population;Emerging Tobacco Products;epidemiologic discoveries;Evaluation;experience;Faculty;Financial Hardship;Funding;Future;Genetic;Genomics;Goals;graduate student;Growth;Health behavior;Health Services Accessibility;improved;Incentives;Incidence;Inflammatory;innovation;Institution;interdisciplinary collaboration;Intervention;Intervention Trial;Laboratories;Life Style Modification;lung cancer screening;Malignant Neoplasms;member;Menthol;Mentors;Mentorship;metabolomics;mhealth interventions;Monitor;mortality;NCI-Designated Cancer Center;Not Hispanic or Latino;novel;Oklahoma;Outcome;Pain management;Pathway interactions;Peer Review;Play;Population Sciences;Positioning Attribute;Postdoctoral Fellow;Poverty;prevent;programs;Publications;Quality of life;Race;racial population;recruit;Research;Research Peer Review;Research Personnel;Resource Sharing;response;Risk;Risk Factors;Role;Rural;rural area;rural cancer care;rural poverty;rural residence;screening;social;socioeconomic disadvantage;Strategic Planning;survivorship;Symptoms;synergism;tobacco prevention;Tobacco use;Tobacco Use Cessation;Training;Treatment Side Effects;tribal Nation;tumor progression;Underserved Population;uptake;Work

PROJECT_TITLE: Cancer Prevention and Control Program


NIH_SPENDING_CATS: Aging;Estrogen;HIV/AIDS;Infectious Diseases;Menopause;Obesity;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE People living with HIV are at a greater risk for obesity and metabolic diseases like diabetes and heart disease because of the effects of the antiviral medicine they have to take to control the HIV virus. Women represent a growing proportion of people living with HIV and are at even greater risk for treatment-related disease when they undergo menopause and loss of estrogen that helps prevent metabolic disease. This project will use a monkey model of postmenopausal women living with HIV to determine if estrogen replacement therapy will prevent the adverse effects of menopause on HIV treatment-caused metabolic disease and the ability of HIV treatment to control virus levels.

PI_NAMEs: KIEVIT, PAUL  (contact);SACHA, JONAH B.

PROGRAM_OFFICER_NAME: WANG, FEI

PROJECT_TERMS: Acceleration;Address;Adipocytes;adipokines;Adipose tissue;Adopted;Adverse effects;adverse outcome;Affect;Age;age related;age-related disease;aging population;AIDS population;antiretroviral therapy;Attenuated;Autopsy;Bar Codes;Biological Assay;Biopsy;Blood;blood glucose regulation;burden of illness;Cardiovascular Diseases;CD4 Positive T Lymphocytes;Cells;Characteristics;Chronic;Clinical Research;Clonality;Collection;comorbidity;demographics;Detection;Diabetes Mellitus;digital;Disease;DNA;Endoscopic Biopsy;Epidemic;ESR1 gene;Estradiol;Estrogen deficiency;Estrogen Replacement Therapy;Estrogen Replacements;Estrogens;experience;extend lifespan;Female;Fibrosis;Glucose;glucose metabolism;Heart Diseases;Heterosexuals;HIV;HIV Infections;HIV/AIDS;Homosexuals;Hormone replacement therapy;Hormone use;Hormones;Hybrids;Immune;Implant;In Situ;Incidence;Infection;Inflammation;Ions;latent HIV reservoir;Life Expectancy;life span;lipid metabolism;Lipids;lymph nodes;Lymphoid;Macaca mulatta;Macrophage;male;Mediator;Medicine;men;Menopause;Metabolic;Metabolic Control;Metabolic Diseases;Metabolism;Modeling;Monitor;Monkeys;Morbidity - disease rate;nonhuman primate;novel;Obesity;obesity risk;Ovariectomy;Pathology;Patients;Peripheral;Persons;Placebos;Plasma;Play;Population;Populations at Risk;Postmenopause;Pre-Clinical Model;Predisposition;prevent;Proviruses;Quantitative Reverse Transcriptase PCR;Regimen;reproductive senescence;response;Risk;RNA;Role;Severities;Sex Differences;Silastic;SIV;Spleen;subcutaneous;T-Lymphocyte;Time;Tissue Sample;Tissues;translational model;transmission process;treatment risk;Viral;Viral reservoir;Viremia;Virus;Virus Latency;Visceral;Woman;Women's Interagency HIV Study;Women's study

PROJECT_TITLE: Effect of estrogen replacement on postmenopausal ART-associated comorbidity and viral latency

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Prevention;Primary Health Care

ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: UNIVERSIDAD DE SAN MARTIN DE PORRES

PHR: PROJECT NARRATIVE Depression and anxiety in old age are often neglected and poorly treated. The wide gap in mental health care among older adults can be tackled by delivering context-appropriate intervention strategies. The long-term goal of this proposal goal is substantially reducing the burden of these common mental conditions.

PI_NAMEs: FLORES-FLORES, OSCAR GUILLERMO (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: acceptability and feasibility;Adult;Aging;Anti-Anxiety Agents;anti-depressive agents;Anxiety;anxiety symptoms;Award;career;Caring;Chronic Disease;Chronic Obstructive Pulmonary Disease;Clinical;Communities;Community Health Aides;community intervention;cost;Data;Dedications;Dementia;depressive symptoms;Diagnosis;diagnostic strategy;disability;Effectiveness of Interventions;effectiveness/implementation hybrid;effectiveness/implementation study;effectiveness/implementation trial;Epidemiology;Equipment and supply inventories;evidence base;experience;experimental study;Family member;Fellowship;Focus Groups;follow-up;future implementation;geriatric depression;Geriatrics;Goals;Grant;Health;health care service utilization;Health Personnel;Health Professional;Health system;healthcare community;Home;Hour;human old age (65+);Human Resources;Impaired cognition;implementation measures;implementation outcomes;implementation science;improved;Individual;Infrastructure;innovation;Intervention;intervention delivery;intervention effect;Interview;low and middle-income countries;Manuals;Measures;Mental Depression;Mental Health;Mental Health Services;Mentors;Mentorship;mid-career faculty;Modeling;multi-component intervention;multidisciplinary;neglect;older adult;Older Population;Outcome;Participant;Patient Self-Report;Patients;Perception;Personal Satisfaction;Persons;Peru;Peruvian;Phase;pilot trial;Population;Population Study;Premature Mortality;Prevalence;problem solving therapy;process evaluation;professor;programs;Psyche structure;Public Health;Qualitative Methods;Quality of life;Questionnaires;Recommendation;Research;Research Design;Research Methodology;Research Personnel;Resource-limited setting;Rewards;Running;symptomatic improvement;Symptoms;Testing;Training;Transportation;treatment arm;treatment as usual;Trust;uptake;Work;World Health Organization

PROJECT_TITLE: A community intervention to promote evidence-based mental health care for olderadults with depressive and anxiety symptoms.

STUDY_SECTION_NAME: International and Cooperative Projects - 1 Study Section[ICP1]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: DOESCHER, MARK P (contact)

PROJECT_TERMS: Address;advocacy organizations;Affect;African American;American Indian community;American Indians;anti-cancer research;Area;Black race;Breast;Businesses;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;cancer research center director;cancer risk;career;Catchment Area;Cellular Phone;Cessation of life;Clinical Trials;Collaborations;Colorectal;Communication;Communities;community advisory board;community engaged research;community engagement;Community Outreach;County;Data;Death Rate;Education;Environment;equity, diversity, and inclusion;Ethnic Population;Fostering;Future;Growth;Health;Health Insurance;Healthcare Systems;High Prevalence;Hispanic;Household;Human Papilloma Virus Vaccination;Incidence;Income;Indigenous;Institution;Insurance Coverage;Kiowa;Latino;Leadership;Link;Logic;Lung;Malignant neoplasm of cervix uteri;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammography;member;Minority Groups;Mobile Health Application;Modeling;Monitor;mortality;Native Americans;NCI-Designated Cancer Center;Obesity;Oklahoma;outreach;Patients;Policies;Population;Population Heterogeneity;Poverty;programs;Prostate;Protocols documentation;Race;racial population;Renal Carcinoma;Research;Research Priority;Risk Factors;Rural;Screening for cancer;Services;Signal Transduction;smoking cessation;smoking prevalence;socioeconomics;Strategic Planning;System;Tobacco use;Training;Training and Education;underserved community;underserved minority;United States;Uterine Cancer;Vision

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Primary Health Care

ORG_CITY: KYIV

ORG_COUNTRY: UKRAINE

ORG_FIPS: UP

ORG_NAME: KYEVO-MOGYLYANSKA AKADEMIYA, NATSIONALNY UNIVERSYTET

PHR: The proposed mixed-methods sequential explanatory study project addresses a highly relevant public health question: what is the implementation landscape for evidence-based transdiagnostic approaches to treat mental disorders in primary healthcare. Mental health disorders are among leading contributors to Ukraine’s poor health profile, with high morbidity, mortality, and disability rates. The information gained through this study can contribute to closing the mental health treatment gap in Ukraine, LMIC, and other low-resources settings.

PI_NAMEs: MAZHNAIA, ALONA  (contact)

PROJECT_TERMS: Address;Adopted;Adoption;Advocacy;Alcohols;Anxiety;anxiety management;Attitude;Behavioral;care delivery;Caring;Characteristics;Cognitive;Communities;community setting;comorbidity;Consensus;coping;cost;Cost Analysis;Country;Data;Diagnostic;diagnostic strategy;disability;Disease;displaced person;Education;Effectiveness;Elements;European;evidence base;experience;Gatekeeping;Group Interviews;Health;Health Care Reform;Health Personnel;Health Policy;health service use;Health Services Accessibility;Health system;health training;Healthcare;Healthcare Systems;Human Resources;implementation determinants;implementation evaluation;implementation outcomes;implementation strategy;implementation study;improved;Infrastructure;International;Knowledge;low and middle-income countries;Medical;medical specialties;Mental Depression;Mental disorders;Mental Health;mental health center;Mental Health Services;Methods;Morbidity - disease rate;mortality;National Health Services;National Institute of Mental Health;Nurses;Opioid;Patients;Perception;Persons;Policy Maker;Population;Positioning Attribute;post intervention;Practical Robust Implementation and Sustainability Model;prevent;Primary Care;Primary Health Care;programs;Provider;Psychiatric therapeutic procedure;Psychosocial Assessment and Care;Public Health;Public Health Schools;Research;Resource-limited setting;Resources;response;Sampling;scale up;service delivery;Service provision;Services;skills;Substance Use Disorder;suicide mortality;Surveys;System;Training;Trauma;Ukraine;Veterans;Waiting Lists

PROJECT_TITLE: A mixed-methods sequential explanatory study to examine the implementation landscape for evidence-based transdiagnostic approaches for mental disorders in primary healthcare in Ukraine.


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

PHR: Project Narrative More than one in five hundred people have genetically based cardiomyopathies that are a leading cause of sudden cardiac death in young people. We will determine the mechanisms by which mutations in the motor that powers cardiac contraction lead to cardiomyopathies, allowing for the design of therapies for preventing or alleviating the disease symptoms.

PI_NAMEs: GOLDMAN, YALE E;OSTAP, E. MICHAEL (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Actins;Affect;Amino Acid Sequence;Architecture;arm;ATP phosphohydrolase;beta-Myosin;Biochemical;Biological Assay;biophysical techniques;Buffers;Calcium;Cardiac;Cardiac Myocytes;Cardiac Myosins;Cardiomyopathies;Contractile Proteins;Contractile System;Dependence;Dilated Cardiomyopathy;Disease;DNA;DNA Sequence Alteration;EFRAC;Electrophysiology (science);Etiology;experimental study;Fibrosis;Filament;gain of function;Gene Mutation;Gene Proteins;Generations;Genetic;Goals;Heart;Heart Diseases;Human;Hypertrophic Cardiomyopathy;Impairment;In Vitro;interstitial;Kinetics;Lead;Left Ventricular Hypertrophy;loss of function;loss of function mutation;Measures;Mechanics;Microfilaments;Microfluidics;Modeling;Molecular;Motility;Motor;Motor Activity;Muscle;Muscle Cells;mutant;Mutate;Mutation;Myocardium;Myofibrils;Myopathy;Myosin ATPase;nanomachine;Nonmuscle Myosin Type IIA;optic trap;optical traps;Outcome;Output;Performance;Persons;Pharmaceutical Preparations;preservation;prevent;Production;Proteins;Regulation;Research;Sampling;Sarcomeres;Signal Transduction;single molecule;sudden cardiac death;Symptoms;System;Techniques;Testing;therapy design;Thin Filament;Thinness;Time;Tissues;Ventricular

PROJECT_TITLE: Mechanochemistry of myosin mutations that cause cardiomyopathy

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Cancer;Clinical Research;Women's Health Research

PI_NAMEs: MANNEL, ROBERT S. (contact)

PROJECT_TERMS: Address;anti-cancer research;Award;Cancer Center;Cancer Center Support Grant;cancer research center director;cancer risk;career development;Catchment Area;Clinical;Collaborations;community engagement;Community Outreach;community setting;design;Development;Direct Costs;Environment;Evaluation;Extramural Activities;Faculty;Female;Fostering;Funding;Goals;Grant;improved outcome;innovation;Institution;interdisciplinary collaboration;Investments;Leadership;Malignant Neoplasms;member;Mentorship;Minority Groups;Minority Women;Mission;new technology;Oklahoma;Outcome;Peer Review;Persons;preference;programs;Publications;recruit;Reporting;Research;Research Personnel;Resource Development;Resource Sharing;Rest;Science;Source;Strategic Planning;Students;Training;Translations;Underrepresented Minority;Universities

PROJECT_TITLE: Developmental Funds


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PI_NAMEs: CAPPELLERI, DAVID JOHN (contact);GOERGEN, CRAIG J.;SOLORIO, LUIS

PROGRAM_OFFICER_NAME: KREPKIY, DMITRIY

PROJECT_TITLE: NRI: Mobile Microrobots for Precision Medicine


NIH_SPENDING_CATS: Complementary and Integrative Health;Immunization;Natural Products;Prevention;Vaccine Related

ORG_CITY: DETROIT

ORG_DEPT: CHEMISTRY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE  The success of vaccination requires the generation of a strong immune response to the inoculated antigens to provide long-term protective immunity against infectious diseases. To accomplish this goal often requires the addition of vaccine adjuvants, substances that do not induce immune response against themselves, but significantly enhance the immunogenicity of co-administered antigens. The goal of this grant application involves exploration of carbohydrate saponin molecules as novel vaccine adjuvants for utilization in humans to combat a wide range of infectious diseases.

PI_NAMEs: NGUYEN, HIEN M (contact);VARGA, STEVEN M

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Adjuvant;aluminum sulfate;Antibody Response;Antigen-Presenting Cells;Antigens;Applications Grants;Azides;B-Lymphocytes;Biodistribution;carbene;Carbohydrates;catalyst;CD8-Positive T-Lymphocytes;Cell Maturation;chemical synthesis;Chemistry;Clinical;clinical application;Clinical Trials;clinically relevant;combat;Communicable Diseases;cost effective;cytokine;Development;Ethers;Evaluation;Exhibits;Fluorescein;Fluorides;Galactose;Generations;Glucose;Glycosides;glycosylation;Goals;High Pressure Liquid Chromatography;Human;Hydrogen Bonding;Hydroxyl Radical;Hypocotyl;Immune response;Immunity;immunogenicity;Immunologics;Immunology;improved;In Vitro;in vivo;Iowa;Label;Link;Mediating;Medicinal Plants;Metabolic;Methods;mouse model;multidisciplinary;Natural Products;Natural Source;novel;novel vaccines;Oligosaccharides;Plasma;preclinical evaluation;Process;Production;QS21;Regulation;Respiratory Syncytial Virus Vaccines;Role;Safety;Saponins;screening;Source;soy;Soyasapogenol;Soyasaponin;Structure;Structure-Activity Relationship;success;T cell response;Therapeutic;tool;Toxic effect;Universities;Vaccination;Vaccine Adjuvant;vaccine immunogenicity;Vaccines;vaccinology;Variant

PROJECT_TITLE: Synthesis and Evaluation of Carbohydrate Vaccine Adjuvants

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: DALLAS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PI_NAMEs: ARGENBRIGHT, KEITH EDWARD;TRIVEDI, MADHUKAR H. (contact);YIN, HELEN L

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TERMS: Academy;Acceleration;Address;Applications Grants;Award;Awareness;Basic Science;career;Career Choice;career development;Clinical Research;Collaborations;Communities;community engagement;Community Health;Competence;Cost Sharing;design;Development;Dimensions;Discipline;Education;Educational Curriculum;Elements;empowerment;Ensure;ethnic minority;Evaluation;Exposure to;externship;Faculty;Fostering;Frequencies;Funding;Future;Gender;Generations;Goals;Grant;Health;House Staffs;improved;Incubators;Individual;Informatics;innovation;Institution;interdisciplinary collaboration;K-Series Research Career Programs;Manuscripts;Medicine;Mentors;Mentorship;Modeling;Modernization;peer;peer coaching;Physicians;pre-clinical research;Program Development;Program Evaluation;programs;racial minority;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resources;Role;Scholars Program;Science;Scientist;Secure;Series;Structure;success;Team Process;Technology;Texas;theories;Thinking;timeline;tool;Training;Training and Infrastructure;Training Programs;translational engagement;translational medicine;translational pipeline;Translational Research;Translations;Vocational Guidance;Woman

PROJECT_TITLE: UT Southwestern Center for Translational Medicine


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Genetic elements known as transposable elements and inflammatory molecules known as inflammasomes are thought to be involved in Alzheimer's disease (AD) but causal links have not been established. We will determine whether a class of transposable elements known as SINE RNAs activate specific inflammasomes and whether blocking this activation is beneficial in models relevant to AD. These studies will provide a deeper understanding of the role of these inflammatory transposable elements in AD and can serve as a foundation for future development of targeted therapeutics.

PI_NAMEs: AMBATI, JAYAKRISHNA  (contact);GELFAND, BRADLEY DAVID

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: abeta accumulation;Abeta clearance;abeta deposition;Age related macular degeneration;age related neurodegeneration;Alu Elements;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-Protein;Anatomy;Animal Disease Models;Animal Model;Behavioral;Brain;brain cell;CASP1 gene;cell type;Cells;Characteristics;Chronic;Cicatrix;Cognitive;cognitive function;Complex;cytokine;cytotoxicity;Degenerative Disorder;Deposition;Development;DNA Transposable Elements;efficacy testing;Elements;Epidemiology;Eye;Foundations;functional outcomes;Future;Genetic;genetic element;Genetic Transcription;Genome;Human;Human Characteristics;Human Genome;hyperphosphorylated tau;IL18 gene;Immune;immune activation;Immune response;Immune signaling;Immunology;Impairment;improved;Individual;Inflammasome;Inflammation;Inflammatory;inhibitor;Interleukin-1 beta;Knowledge;Licensing;Link;Maps;Mediating;Microglia;Modeling;Molecular;mouse genome;mouse model;Multiple Sclerosis;Mus;Nerve Degeneration;Neurofibrillary Tangles;neuroinflammation;novel;Nuclear;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Phagocytosis;pharmacologic;Phosphorylation;progressive neurodegeneration;protein aggregation;Proteins;Retrotransposition;Retrotransposon;RNA;RNA Helicase;RNA Polymerase III;Role;Science;Senile Plaques;sensor;Short Interspersed Nucleotide Elements;Signal Pathway;Signal Transduction;small molecule inhibitor;Source;spatiotemporal;Structure of retinal pigment epithelium;targeted treatment;tau aggregation;tau Proteins;Techniques;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;Toxic effect;Transcript;Translational Research;Visualization

PROJECT_TITLE: Defining the role of SINE retrotransposons and inflammasome activation in Alzheimer's disease


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Microbiome

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will identify, for the first time, the microbial factors that govern colonization and immunogenicity in ocular commensal bacteria. Once these factors are known, there is potential for significant advancement in the development of ocular probiotics to act as novel therapies to prevent or treat eye disease.

PI_NAMEs: ST LEGER, ANTHONY J (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Address;Adhesions;Affect;Antigen Presentation;antimicrobial;Area;Automobile Driving;Bacteria;Bacterial Genes;Candida albicans;Candidate Disease Gene;Caring;Cell Wall;Cells;Clinical;clinically relevant;commensal bacteria;Comparative Genomic Analysis;Complement;Cornea;Corynebacterium;cost;Data;Dendritic Cells;Development;Disease;Economic Burden;Eye;Eye Development;Eye diseases;Formulation;Foundations;Future;Gene Modified;Genes;Genomics;Glaucoma;Goals;Health;host-microbe interactions;Hour;Human;IL17 gene;Immune;Immune response;Immunity;immunogenicity;In Vitro;in vivo;Infection;Inflammation;insight;Interleukin-1 beta;Knowledge;Laboratories;Libraries;Ligation;microbial;microbial products;microbiome;Mucous Membrane;Mus;mutant;Mutate;Mutation;Nature;Neutrophil Infiltration;novel;novel therapeutics;ocular microbiome;ocular surface;ocular surface disease;Pathogenicity;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Play;prevent;probiotic therapy;Probiotics;Production;Proteins;Pseudomonas aeruginosa;Public Health;Research;response;Rest;Role;screening;side effect;Signal Transduction;Source;Symbiosis;symptom treatment;T-Cell Receptor;Testing;Time;Translating;Universities;virtual;Visual impairment;γδ T cells

PROJECT_TITLE: Understanding the microbial requirements for colonization and immunogenicity of commensal bacteria at the ocular surface


NIH_SPENDING_CATS: Cancer;Women's Health Research

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

PROJECT_TERMS: Address;Appointment;Basic Science;Cancer Center;Cancer Center Support Grant;cancer research center director;cancer risk;career;Catchment Area;Clinical;Clinical Cancer Center;Clinical Research;Collaborations;Communication;community advisory board;community engagement;Community Outreach;community setting;Component of the Center for Cancer Research;Data;Decision Making;design;Development;Diabetes Mellitus;Doctor of Philosophy;Education;Effectiveness;Ensure;equity, diversity, and inclusion;Evaluation;Evaluation Research;experience;Faculty;Fostering;Funding;Geroscience;Goals;improved outcome;Leadership;Malignant Neoplasms;meetings;Mentorship;Minority Groups;Minority Women;Mission;NCI Center for Cancer Research;Oklahoma;operation;Outcome;Persons;Play;Policies;Positioning Attribute;Process;Productivity;programs;Publications;Reporting;Research;Research Activity;Resource Allocation;Resource Sharing;Role;Science;Strategic Planning;Students;Training;Translational Research;Translations;Underrepresented Minority;Update

PROJECT_TITLE: Leadership, Planning and Evaluation


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Hematology;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: 2R01DK095112-05A1 Anemia is a common health issue affecting all age groups. While varying in their underlying causes, all forms of anemia require adaptation of iron metabolism. This proposal will identify and characterize signaling mechanisms by which iron metabolism and red blood cell production are interrelated, and will test approaches to modify this signaling in the treatment of the blood disorder beta thalassemia.

PI_NAMEs: FLEMING, ROBERT E (contact);GINZBURG, YELENA ;RIVELLA, STEFANO

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Affect;Affinity;age group;Anemia;Attention;Basic Science;beta Thalassemia;Binding;Binding Sites;Biological Models;blood treatment;BMP6 gene;Bone Marrow;Cell Culture Techniques;cell type;Cells;Circulation;Clinical Sciences;Collaborations;Data;derepression;diferric transferrin;Disease;disease model;EPOR gene;Erythroblasts;Erythrocytes;Erythropoiesis;Erythropoietin;Exhibits;falls;Functional disorder;Goals;Health;Hematological Disease;Hepatocyte;hepcidin;Hereditary hemochromatosis;Homeostasis;human disease;human model;improved;In Transferrin;insight;Iron;iron metabolism;knock-down;Knockout Mice;Ligands;lipid nanoparticle;Liver;Lobe;Mediating;meetings;Molecular;mouse model;mRNA delivery;Mus;Mutate;novel;novel therapeutics;Participant;Patients;Physiological;Plasma;Plasma Proteins;Process;Production;Property;Publishing;receptor;receptor mediated endocytosis;Receptor Signaling;Regulation;Reporting;Role;sensor;Serum;Signal Pathway;Signal Transduction;Signaling Molecule;Specificity;System;Testing;TFR2 gene;TFRC gene;therapeutic target;Transferrin;uptake

PROJECT_TITLE: Regulatory Role of Transferrin in Erythropoiesis and Iron Metabolism

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Patient Safety;Serious Mental Illness

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Electroconvulsive therapy (ECT) is the most effective therapy for adults with major depression; however, some patients fail to respond despite an adequate trial, and ECT can produce negative cognitive effects. In this revised four site, prospective study we propose the first investigation of ECT outcome integrating multiple types of data including clinical and cognitive measures, whole-brain neuroimaging, EEG, and E-field modeling to establish the mechanisms underlying ECT-induced antidepressant response (response biomarkers) and negative cognitive effects (safety biomarkers). Using this approach in patients with major depressive disorder (n = 230), we will confirm the “sweet spot” of ECT dosing in order to maximize antidepressant benefit and cognitive safety.

PI_NAMEs: NARR, KATHERINE L (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Acute;Address;Adult;Adverse effects;Algorithms;Amnesia;Anatomy;anti-depressive agents;Biological Markers;biomarker identification;Blood flow;Brain;Clinical;Clinical Research;Cognitive;cognitive benefits;Collaborations;Corpus striatum structure;Data;Disease remission;Disfluent;Dissociation;Dose;effective therapy;electric field;Electroconvulsive Therapy;Electroencephalography;Ensure;Executive Dysfunction;executive function;follow-up;Functional Magnetic Resonance Imaging;Hippocampus;Image;imaging study;Impaired cognition;improved;Individual;Intervention;Investigation;Knowledge;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;magnetic seizure therapy;Major Depressive Disorder;Measures;Medial;meter;Methodology;Methods;Modeling;multiple data types;National Institute of Mental Health;neuroimaging;Neuronal Plasticity;noninvasive brain stimulation;Outcome;Patient-Focused Outcomes;Patients;Phenotype;Prefrontal Cortex;Process;Prospective Studies;Protocols documentation;Public Health;Research Infrastructure;response;response biomarker;Safety;Sample Size;Seizures;side effect;Site;Spottings;Standardization;Structure;System;Testing;Thalamic structure;therapy outcome;Time;verbal;Weight

PROJECT_TITLE: 1/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)


NIH_SPENDING_CATS: Behavioral and Social Science;Disability Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE This project will use an integrated data approach to explore racial differences in the effectiveness of supplemental reading interventions that provide intensive, targeted support to students with or at-risk for reading disability (RD). To date, the paucity of studies that disaggregate findings by student race make it impossible to know whether reading interventions deemed evidence-based are generalizable and valid for Black students. This project will advance our understanding of the persistent disparities in reading achievement between Black and White students and potential sources of individual difference for these groups.

PI_NAMEs: TOSTE, JESSICA R. (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Academic achievement;academic intervention;Accounting;Achievement;Address;Affect;African American student;Age;Archives;Black race;Characteristics;Complex;Critical Race Theory;Data;Data Aggregation;Data Analyses;data integration;data repository;Data Set;Development;Disability status;Disparity;Education;education research;Effectiveness;Effectiveness of Interventions;eighth grade;evidence base;fourth grade;Goals;Growth;Health;Individual;Individual Differences;Infrastructure;Intervention;intervention effect;Intervention Studies;Investments;Language;Measures;Methodology;Modeling;Oral;Outcome;peer;Personal Satisfaction;Positioning Attribute;Poverty;psychologic;Race;racial difference;Reading;reading ability;Reading Disabilities;Research;Research Personnel;Research Project Grants;Resources;response;Risk;Role;Sampling;Scientific Inquiry;skills;Social Environment;Socioeconomic Status;Source;Statistical Models;stem;student participation;Students;System;Systems Theory;Testing;therapy development;Time;treatment effect;treatment response;United States National Institutes of Health

PROJECT_TITLE: An Integrated Data Approach to Exploring Racial Differences in Reading Intervention Effectiveness

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Prevention

PI_NAMEs: MOORE, KATHLEEN N. (contact)

PROJECT_TERMS: Bioinformatics;Biological Markers;Cancer Center;Cancer Center Support Grant;career;Catchment Area;Cell Therapy;Child;Clinical;Clinical Cancer Center;Clinical Data;Clinical Investigator;Clinical Protocols;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Design;Collaborations;Communities;Conceptions;Data;data integrity;data management;Development;Disease;Enrollment;Ensure;Grant;Individual;innovation;Inpatients;Institution;Intervention;Intervention Studies;Intervention Trial;investigator-initiated trial;life span;member;Minority;Monitor;outreach;Patients;Peer Review;Phase;Prevention;Process;programs;Protocols documentation;Publications;quality assurance;recruit;Reporting;Research;Research Activity;Research Infrastructure;research study;Research Support;Rural Population;Safety;Science;screening;Serious Adverse Event;Services;Therapeutic Trials;Time;Training;Training and Education;Translational Research;Underserved Population;Woman;Women's trial;Work;Writing

PROJECT_TITLE: Clinical Protocol and Data Management


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Infertility;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Sleep Research;Women's Health Research

PHR: Narrative Circadian disruptions, such as shift work, impair fertility in humans and other animals, and this may be due in part to food consumption at the wrong time – at odds with the normal biological rhythm. In mice, we found that mis-timed food reduces reproductive success. In this application, we will build on this by determining how light cycles, food cycles, and biological clocks in the hypothalamus interact in the control of reproduction.

PI_NAMEs: BUTLER, MATTHEW P (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Animal Model;Animals;Behavior;Biological Clocks;Biological Rhythm;Birth;Cell Nucleus;Chimera organism;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Competence;Consumption;Contraceptive methods;Cues;Darkness;Data;Desire for food;Eating;endometriosis;Energy Intake;Estradiol;Exposure to;Failure;Fasting;feeding;Female;Fertility;fitness;Food;food consumption;food restriction;GNRH1 gene;Goals;Health;Hormones;Hour;Human;human model;Hypothalamic structure;Impairment;in vivo;Jet Lag Syndrome;KISS1 gene;Laboratories;Lead;Light;Link;Low Birth Weight Infant;Luteinizing Hormone;male;mating behavior;Measures;Menstrual cycle;Metabolic;Mus;Mutant Strains Mice;Neurons;Outcome;Ovulation;Partner in relationship;Pathway interactions;Periodicity;Persons;Phase;Physiology;Population;Pre-Clinical Model;preference;Premature Birth;Protocols documentation;Public Health;Quality of life;Reproduction;reproductive;Reproductive Behavior;reproductive function;Reproductive Health;Reproductive Physiology;reproductive success;Resting Phase;Risk;Role;Running;Schedule;sex;Sex Behavior;Sex Differences;shift work;social;Speed;Spontaneous abortion;success;System;tau mutation;Testing;Therapeutic Intervention;Time;Ventricular;Weight

PROJECT_TITLE: The circadian time of food intake and its effect on reproductive health

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE  To adjust maternal metabolism, there is a significant increase in maternal insulin production during pregnancy. This project is designed to define how pancreatic α-cells regulate maternal insulin production during pregnancy.

PI_NAMEs: SHAO, JIANHUA  (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Ablation;Adipocytes;Adult;Alpha Cell;Amino Acids;Beta Cell;Blood;Blood Glucose;Cell Proliferation;Cell Survival;Cells;Circulation;Communication;Compensation;design;Endocrine;extracellular vesicles;Failure;Fetal Growth;Foundations;Future;Gene Deletion;Genetic;genetic approach;Gestational Diabetes;Glucagon;glucagon-like peptide 1;Glucose;glucose tolerance;Health;Hormones;Human;Impairment;improved;Insulin;Insulin Resistance;insulin secretion;islet;knockout gene;Knowledge;Label;Lactation;Link;lipid metabolism;Mediating;Metabolic;Metabolic stress;Metabolism;MicroRNAs;miRNA expression profiling;Modeling;mouse model;Mus;novel;Nutrient;offspring;Organ;Pancreas;paracrine;Pathologic;Physiological;Placental Lactogen;Play;Population;Pregnancy;Pregnancy Outcome;pregnant;Production;programs;Prolactin Receptor;Proliferating;Proteins;Rattus;Receptor Signaling;reconstitution;Reporting;Research;restoration;Role;Series;Signal Transduction;Structure of alpha Cell of islet;success

PROJECT_TITLE: Alpha cell-derived Extracellular Vesicles and Maternal Insulin Production

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(02)M]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: ASCH, ADAM S (contact)

PROJECT_TERMS: advanced disease;anti-cancer research;authority;Cancer Center;Cancer Center Support Grant;Clinical;Clinical Cancer Center;Clinical Data;Clinical Protocols;Clinical Research;Clinical Trials;Committee Members;Committee Membership;Conduct Clinical Trials;Data;data management;design;Discipline;Disease;Elements;Ensure;Evaluation;experience;Goals;Guidelines;Health Sciences;human subject;Institution;Institutional Policy;Institutional Review Boards;Knowledge;Letters;Life Cycle Stages;Malignant Neoplasms;member;Monitor;Oklahoma;patient population;Patients;Process;Protocols documentation;Research;Research Personnel;Research Priority;research study;Research Support;Resources;Review Committee;Safety;System;tool;Universities;Voting;Writing

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Infectious Diseases;Organ Transplantation;Transplantation

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Human cytomegalovirus (CMV) is the most common viral infection to complicate heart transplantation and is a well-established risk factor for rejection, a significant barrier to allograft function and longevity. The goal of this project is to create a high dimensional cartography at single-cell resolution of the cardiac allograft tissue microenvironment during cellular rejection with CMV infection to identify mechanisms of viral rejection and immune cell signatures that track with tissue disease state in the blood. Successful completion of these proposed studies will nominate novel, non-invasive biomarkers to predict CMV-related outcomes in heart transplant recipients and guide the development of rejection treatment strategies that selectively mitigate viral immune dysregulation. .

PI_NAMEs: SEN, PRITHA  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Acceleration;Activated Lymphocyte;Advisory Committees;allograft rejection;Allografting;Animal Model;Antigen Presentation;Antigens;Area;Automobile Driving;Award;Bioinformatics;Biological Markers;Biology;Biopsy;Blood;Cardiac;career development;Cell Communication;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chemokine;Clonal Expansion;cohort;Cytomegalovirus;Cytomegalovirus Infections;cytotoxic;Cytotoxic T-Lymphocytes;Data;design;Development;Development Plans;diagnostic development;diagnostic tool;Disease;Endothelial Cells;Epithelium;Epitopes;Flow Cytometry;Fostering;Foundations;Funding;General Hospitals;Genetic Transcription;Goals;Graft Rejection;Heart;heart allograft;Heart Transplantation;high dimensionality;high risk;Human;Human Subject Research;Immune;Immune System Diseases;Immunity;Immunofluorescence Microscopy;immunological synapse;Immunology;Immunophenotyping;Immunosuppression;In Situ Hybridization;in vivo;Infiltration;Inflammasome;Inflammatory;Interdisciplinary Study;isoimmunity;Ligands;Longevity;Major Histocompatibility Complex;Maps;Massachusetts;Measurement;Mediating;Membrane Proteins;Memory;Mentorship;Methods;Molecular;Mononuclear;Morbidity - disease rate;multiple omics;Non-Invasive Detection;novel;Opportunistic Infections;Organ;Outcome;pathogen;Phagocytes;Pharmaceutical Preparations;Phenotype;Physicians;Population;Precipitation;precision medicine;Production;Proteins;Proteomics;receptor;Research;Research Personnel;Resolution;response;Risk;Risk Factors;Role;Scientist;shift work;single-cell RNA sequencing;System;T cell receptor repertoire sequencing;T-Cell Receptor;T-Lymphocyte Subsets;Testing;Tissues;trafficking;Training;translational study;transplant centers;Transplant Recipients;Transplantation;Transplanted Heart Complication;treatment strategy;Viral;Viral Cytopathogenic Effect;Viral reservoir;Viremia;Virus Diseases;Work

PROJECT_TITLE: High-dimensional single-cell mapping to define immune signatures of cytomegalovirus-associated rejection in cardiac transplantation

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: UNIVERSITY

ORG_NAME: UNIVERSITY OF MISSISSIPPI

ORG_STATE: MS

PHR: Project Narrative  The University of Mississippi proposes to establish the Glycoscience Center of Research Excellence (GlyCORE), a new University-wide center to study how carbohydrates and carbohydrate-containing molecules affect human health. GlyCORE will support investigators in glycoscience through direct funding of selected research projects, establish mentors for early career investigators, support the recruitment of new faculty in glycoscience, and develop local and regional meetings for investigators to discuss their work. GlyCORE will also support the establishment of three central research cores to support these investigators with cutting-edge biomedical research tools.

PI_NAMEs: ROSS, SAMIR A;SHARP, JOSHUA S (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Address;Affect;Alabama;Area;Arkansas;Biochemistry and Cellular Biology;Bioinformatics;Biological;biological systems;Biomedical Research;Biophysics;Carbohydrates;career;Cell Communication;Cells;Centers of Research Excellence;Chemicals;Chemistry;Chromatography;Communities;computational chemistry;Confocal Microscopy;Core Facility;Data Analyses;Dedications;Destinations;Development;Discipline;Energy Metabolism;experience;Faculty;Faculty Recruitment;faculty support;Financial Support;Funding;Future;glycation;Glycobiology;Glycosides;Health;Human;human disease;Image;Immunohistochemistry;improved;In Vitro;in vivo;innovation;Institution;instrumentation;interest;International;Kentucky;Lectin;Louisiana;Mass Spectrum Analysis;meetings;member;Mentors;Mentorship;Mississippi;Missouri;Modernization;Natural Products;Nature;Neurosciences Research;NMR Spectroscopy;Participant;Pharmacologic Substance;Pharmacology;Phase;Physiological;Pilot Projects;Play;Polysaccharides;Program Development;programs;Protein-Carbohydrate Interaction;Proteins;Publishing;Recording of previous events;recruit;Regulation;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;response;Role;Science;Services;simulation;symposium;Teacher Professional Development;Tennessee;tool;tool development;United States National Academy of Sciences;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: GlyCORE:  Glycoscience Center of Research Excellence


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: SHARP, JOSHUA S (contact)

PROJECT_TERMS: Administrator;Advisory Committees;Applications Grants;Area;Award;Biomedical Research;biophysical properties;Carbohydrates;career;career development;Centers of Research Excellence;Collaborations;Communities;Critiques;Decision Making;design;Destinations;Development;effectiveness evaluation;Evaluation;Evaluation Research;experience;Faculty;Faculty Recruitment;Feedback;formative assessment;Funding;Funding Mechanisms;Generations;Glycobiology;Glycosides;Goals;Grant;improved;Infrastructure;infrastructure development;Institution;institutional capacity;Interdisciplinary Study;interest;Lead;meetings;member;Mentors;Mentorship;microbial;Mississippi;Modeling;Natural Products;Nature;outreach;Peer Review;Performance;Phase;Pilot Projects;Play;Preparation;Principal Investigator;Process;Program Development;Program Effectiveness;programs;recruit;Research;research and development;Research Infrastructure;Research Personnel;Research Proposals;Research Support;Resources;Role;Science;senior faculty;skills;Strategic Planning;Strategic vision;symposium;System;Teacher Professional Development;tool;Travel;United States National Institutes of Health;Universities;Viral;Vision;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Hematology;Orphan Drug;Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Multiple myeloma is currently considered incurable due to the development of drug resistance disease that ultimately causes patient’s death. This study is expected to define a new mechanism and a factor for drug resistance in myeloma. It will also develop assays to analyze individual patients’ drug response as well as reagents to reduce drug resistance. Such assays may be used to determine which patients might harbor the specific resistance factor and therefore to select patients who might most benefit from a future therapy targeting the causative factor identified here.

PI_NAMEs: MIYAMOTO, SHIGEKI  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: activating transcription factor;Apoptotic;Bioinformatics;Biological Assay;Bone Marrow;Bortezomib;cancer type;Cell secretion;Cell Separation;Cell Survival;cell type;Cells;Cessation of life;Clinical;Disease;Disease Progression;Disease Resistance;Drug resistance;drug resistance development;efficacy testing;Extracellular Matrix;Extracellular Matrix Proteins;Future;Generations;Genes;Goals;Hematologic Neoplasms;Hematopoietic Neoplasms;Hyaluronan;Hyaluronic Acid;immune modulating agents;In Vitro;in vivo;individual patient;innovation;Length;link protein;Mediating;mesenchymal stromal cell;Modeling;Monoclonal Antibodies;Multi-Drug Resistance;multicatalytic endopeptidase complex;Multidrug Resistance Induction;Multiple Myeloma;Mus;neutralizing antibody;new therapeutic target;Newly Diagnosed;novel;novel marker;novel therapeutics;Oncogenic;Pathogenicity;Pathologic;Patient Selection;Patients;Pharmaceutical Preparations;Plasma;prevent;Progressive Disease;Proteasome Inhibitor;Proteoglycan;Proteolysis;Reagent;receptor;Refractory;Relapse;Resistance;Resistance development;resistance factors;resistance mechanism;response;Role;Signal Induction;Signal Pathway;Signal Transduction;targeted treatment;Testing;Therapeutic;transcriptome sequencing;transcriptomics;tumor microenvironment;Xenograft procedure

PROJECT_TITLE: New Multi-Drug Resistance Mechanism in Multiple Myeloma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: absorption;Address;Aerosols;Affinity;Analytical Chemistry;Binding;Bioinformatics;Biological;Biological Assay;Biomedical Research;biophysical analysis;biophysical chemistry;biophysical properties;biophysical techniques;Biophysics;Carbohydrates;Carbon;Centers of Research Excellence;Characteristics;Charge;chemical release;chemical resource;Chemistry;Chromatography;Collaborations;Communities;Complex;Complex Mixtures;computational chemistry;Computer software;Coupled;Data;Data Analyses;data modeling;Dedications;depolymerization;Derivation procedure;design;Detection;Development;Diagnostic;Equipment;Experimental Designs;flexibility;Fluorescence;Glycobiology;Glycoconjugates;Glycosaminoglycans;Glycosides;Growth;High Pressure Liquid Chromatography;Institution;instrumentation;interest;investigator training;Link;Mass Spectrum Analysis;Measures;metabolome;metabolomics;Methods;Mississippi;Modernization;Modification;Natural Products;Nature;Neurosciences;Pathway Analysis;Pathway interactions;Phase;physical property;Pilot Projects;Polysaccharides;Porosity;Preparation;programs;protein metabolite;Protein-Carbohydrate Interaction;Proteome;Proteomics;Research;Research Personnel;Resolution;Resources;Role;Sampling;Science;secondary metabolite;Services;Spectrophotometry;Statistical Data Interpretation;Statistical Models;Structure;Structure-Activity Relationship;Support System;Surveys;System;Systems Biology;tandem mass spectrometry;Techniques;Technology;Testing;tool;Training;Universities;X-Ray Crystallography

PROJECT_TITLE: Analytical and Biophysical Research Core


PI_NAMEs: MANNEL, ROBERT S. (contact)

PROJECT_TERMS: authority;Awareness;Behavioral Research;Biometry;Cancer Center;Cancer Center Support Grant;cancer research center director;Communication;community engagement;Community Outreach;Complex;Core Facility;Critiques;Cytometry;Dedications;Doctor of Philosophy;Ensure;Equipment;Evaluation;Goals;Health Sciences;Health Technology;Infrastructure;Institution;Laboratories;Leadership;member;Mentorship;mHealth;Molecular Biology;Monitor;Names;NCI Center for Cancer Research;Oklahoma;Pathology;Policies;Population Research;Procedures;Process;Productivity;programs;Quality Control;recruit;Reporting;Research;Research Design;Research Infrastructure;Resource Sharing;Resources;satisfaction;Schedule;Services;Structure;System;Technical Expertise;Technology;Tissues;Training;Universities;web page

PROJECT_TITLE: Shared Resources Management

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: ROMAN, GREGG W (contact)

PROJECT_TERMS: Address;automated analysis;Awareness;Biological;Biological Assay;Biotinylation;Carbohydrates;Cell Physiology;Cells;Cellular biology;Cellular Structures;Centers of Research Excellence;Chemicals;Chemistry;Complex;Computer Assisted;Computer software;Computer Workstations;Computers and Advanced Instrumentation;Confocal Microscopy;Consult;Data;Development;Dimensions;Disease;Ensure;Extracellular Structure;Fiji;Fluorescence Resonance Energy Transfer;Goals;Health;Human;Image;Image Analysis;imager;imaging platform;imaging system;Imaging Techniques;in vivo;Individual;insight;Instruction;instrument;instrumentation;Label;Laser Scanning Confocal Microscopy;Lectin;Location;Maintenance;Maps;Measures;Methods;Microscope;Microscopic;Microscopy;Mississippi;Modernization;Molecular;molecular dynamics;Motor;novel strategies;operation;Organism;particle;Phase-Contrast Microscopy;physical property;Physiological;Polysaccharides;Preparation;preservation;programs;Property;protein protein interaction;protein transport;Protocols documentation;Reagent;Research;Research Personnel;response;Role;Sampling;Schedule;Specific qualifier value;Specificity;Subcellular structure;superresolution imaging;System;Techniques;Tissues;tool;Training;Training Programs;Universities

PROJECT_TITLE: Imaging Research Core


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Networking and Information Technology R&D (NITRD)

PI_NAMEs: DOERKSEN, ROBERT J (contact)

PROJECT_TERMS: Analytical Chemistry;Big Data;Biochemical Pathway;Bioinformatics;biophysical chemistry;Categories;Centers of Research Excellence;computational chemistry;Computer software;computer studies;computerized tools;Computing Methodologies;Data;Data Analyses;Educational process of instructing;experience;Glycoconjugates;Glycoproteins;glycosylation;Goals;Health;Human;Human Resources;Image;Individual;interest;Investigation;Ligands;Mass Spectrum Analysis;meetings;member;metabolomics;Methods;Mississippi;Modernization;Output;outreach;Participant;Pathway Analysis;Pilot Projects;Polysaccharides;programs;Property;Proteins;Proteomics;Research;Research Personnel;Research Support;Scientist;skills;small molecule;Speed;Statistical Models;Structure;Students;sugar;Systems Biology;Talents;Training;Universities;web interface;Work

PROJECT_TITLE: Computational and Bioinformatics Research Core


NIH_SPENDING_CATS: Aging;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

PHR: Alternative lengthening of telomeres (ALT) is responsible for telomere maintenance in some cancers and can be activated in other cancers by anti-telomerase treatments. The proposed research will unravel the mechanism of ALT through identification and quantitative characterization of genetic, structural, and environmental factors af- fecting ALT establishment in yeast, and it will serve as a roadmap to perform quantitative studies of ALT in humans.

PI_NAMEs: COMERON, JOSEP M (contact);MALKOVA, ANNA L

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Affect;Age related pathologies;Aging;Air;assault;Barrett Esophagus;Biological Assay;Biological Markers;Biology;Biosensor;Bypass;Cadmium;Cancer Model;cancer type;carcinogenicity;Carcinogens;Cell Aging;Cell model;Cells;Characteristics;Chromosome Structures;Chromosomes;Computer Models;Development;diagnostic tool;Disease;DNA damage checkpoint;DNA metabolism;Early Diagnosis;Environmental Exposure;Environmental Pollutants;Environmental Risk Factor;environmental stressor;Eukaryota;Event;Exposure to;Frequencies;Future;Generations;Genes;Genetic;Genetic Recombination;Goals;Human;human model;Individual;innovation;insight;Intervention;Invaded;Malignant Neoplasms;Mediating;Medical;Methodology;Methods;Minority;Modeling;Molecular;Molecular Profiling;Molecular Structure;Mutation;Nature;novel strategies;Outcome;oxidative damage;Oxidative Stress;Paraquat;Pathway interactions;Population;Population Genetics;Precancerous Conditions;precursor cell;prevent;Process;Proteins;Quantitative Evaluations;Regenerative capacity;Research;Saccharomyces cerevisiae;Saccharomycetales;senescence;senescent cell;Signal Pathway;Southern Blotting;stem cells;structural determinants;Structure;Survivors;System;Techniques;Telomerase;telomere;Telomere Maintenance;Telomere Pathway;Telomere Recombination;Telomere Shortening;Testing;Toxin;Ulcerative Colitis;Yeast Model System;Yeasts

PROJECT_TITLE: Genetic and environmental factors affecting alternative lengthening of telomeres

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-J(02)M]


PI_NAMEs: JONES, KENNETH LLOYD (contact)

PROJECT_TERMS: Bioinformatics;Biological Assay;Biomedical Research;cancer cell;Cancer Center;Cancer Center Support Grant;Cell Cycle;Cells;Complex;Computer Analysis;computing resources;Consultations;Core Facility;Cytometry;Data;Data Collection;Databases;DNA sequencing;Doctor of Philosophy;Electrophoresis;Experimental Designs;Flow Cytometry;functional genomics;Funding;Gel;Genes;Genomics;Goals;Health Sciences;high throughput screening;high throughput technology;Image;Institution;instrumentation;Laboratories;liquid chromatography mass spectrometry;Location;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;member;Metabolic;metabolomics;Microscopy;Molecular Biology;Molecular Weight;multimodality;Multiomic Data;nano;next generation;Nucleic acid sequencing;Nucleic Acids;Oklahoma;Peer Review Grants;Peptides;Post Translational Modification Analysis;Preparation;protein expression;Proteins;Proteomics;Protocols documentation;Reporting;Research;Research Personnel;Resolution;Resource Sharing;Sampling;Science;screening;Services;Signal Transduction;small molecule;Technology;Training;Universities

PROJECT_TITLE: Molecular Biology and Cytometry Research Shared Resource


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE This project has direct relevance to and will maximize the value of the NIH-funded BRAIN Initiative by proactively engaging diverse stakeholders in anticipating and resolving challenges to sharing human data from BRAIN Initiative studies. This project will provide critical empirical data about specific data sharing challenges and concerns, and will employ a rigorous process of deliberation involving multiple diverse stakeholder groups to generate a comprehensive set of empirically informed policy and practice options that address challenges distinctive to BRAIN Initiative research.

PI_NAMEs: MCGUIRE, AMY L (contact);SHETH, SAMEER ANIL

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Address;Adoption;Advisory Committees;Advocate;Agreement;Attitude;Biomedical Research;Brain;BRAIN initiative;cohort;Consent;Consent Forms;Contracts;Data;data ecosystem;data sharing;Deep Brain Stimulation;Ensure;Equity;Ethics;experience;Funding;Future;genomic data;Genomics;Goals;Human;human data;improved;Individual;Industry;Inequity;Infrastructure;innovation;innovative neurotechnologies;insight;interest;interoperability;Interview;Investments;Laws;Methods;neural;neuroethics;Neurosciences;Participant;Patients;Policies;Policy Developments;Practice Guidelines;precision medicine;preference;Privacy;Process;Productivity;programs;Research;Research Personnel;Science Policy;Social Sciences;stakeholder perspectives;Structure;Subgroup;success;Surveys;Testing;Thinking;Time;Trust;United States National Institutes of Health;Work

PROJECT_TITLE: BRAINshare: Sharing Data in BRAIN Initiative Studies


NIH_SPENDING_CATS: Cancer;Prevention

PI_NAMEs: FUNG, KAR-MING  (contact)

PROJECT_TERMS: anti-cancer research;arm;Automation;Basic Science;biobank;Biological Markers;Biological Specimen Banks;biomarker evaluation;Blood;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;Catalogs;Cells;Certification;Charge;Clinical Trials;Collaborations;Collection;Complex;Computer software;Computers;Consultations;dashboard;Data;Databases;Dedications;Detection;direct patient care;Doctor of Philosophy;Documentation;Ensure;Equipment;Evaluation;experience;Experimental Designs;Fees;Fluorescence;Formalin;Fostering;Freezing;Fresh Tissue;Funding;Grant;Histology;histotechnology;Human;human tissue;Image;Image Analysis;Immunofluorescence Immunologic;Immunohistochemistry;improved;In Situ Hybridization;In Situ Nick-End Labeling;innovation;Institution;interest;Intranet;Laboratory Research;Lasers;Liquid substance;Location;Malignant Neoplasms;Manuals;member;Microscopy;Neoplasm Circulating Cells;neoplastic cell;operation;Paraffin;Paraffin Embedding;Pathologist;Pathology;Patient Care;patient privacy;Patient-Focused Outcomes;Peer Review;Population Heterogeneity;preservation;prevent;programs;Publications;quality assurance;Quantitative Evaluations;recruit;Reporting;Reproducibility;Research;Research Personnel;Research Project Grants;Resource Sharing;Retrieval;S10 grant;Sampling;Scanning;screening;Secure;Services;Site;Slide;specific biomarkers;Specimen;Stains;Standardization;success;Therapeutic;Tissue Banks;Tissue Embedding;Tissue Microarray;tissue processing;Tissue Sample;Tissues;Translating;Translational Research;United States National Institutes of Health;Variant;waiver;web site;Work

PROJECT_TITLE: Tissue Pathology and Biospecimen Shared Resource


NIH_SPENDING_CATS: Hematology;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE – PUBLIC HEALTH RELEVANCE We submit that thrombus formation in response to normal, physiological bleeding produced by puncture wounds or biopsies or other causes is fundamental to human health and is still poorly understood. We do not yet have the penetrating ultrastructural analysis of a forming clot that is required to build conceptual paradigms based on a structural characterization of the actual clot that forms. The studies proposed test a novel clotting paradigm, Cap and Build, and should greatly increase the predictive value of that paradigm. In brief, the research should yield through signaling tests and adhesive mutant studies a sensitive, validated ultrastructural paradigm in which to assess bleeding effects and drug consequences that should be extensible with time and effort to many other systems including arterial bleeding, thrombosis, embolism, and DVT.

PI_NAMEs: STORRIE, BRIAN  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: 3-Dimensional;Accidents;Achievement;adhesion receptor;Adhesives;Affect;Alpha Granule;Antiplatelet Drugs;Arteries;arteriole;Aspirin;autocrine;Autocrine Communication;Blood Coagulation Factor;Blood Platelets;Blood Vessels;Cardiovascular system;Cartoons;clopidogrel;Coagulation Process;Collagen Receptors;comparative;Complex;Cytoplasmic Granules;Data;Defect;Deposition;Diameter;Disease susceptibility;Dose;driving force;drug action;Drug Modulation;Drug Targeting;Embolism;Event;Experimental Models;experimental study;Fibrin;Fibrinogen Receptors;Fibrinolytic Agents;Future;genetic manipulation;Goals;Growth;hazard;Health;Hemorrhage;Hemostatic function;Hermanski-Pudlak Syndrome;Human;Individual;inhibitor;Knowledge;Life;Light;Maintenance;Medical;Medicine;meter;Microscopy;model building;Modeling;Molecular;Morphology;mouse genetics;Mus;mutant;novel;Operative Surgical Procedures;Oranges;Outcome;Patients;Pattern;Penetration;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Platelet Activation;Platelet aggregation;predictive modeling;Predictive Value;Probability;Process;public health relevance;Puncture biopsy;Puncture procedure;Puncture wound;receptor;Reproducibility;Research;Resources;response;Risk;Role;side effect;Signal Transduction;Site;SNAP receptor;Stratification;Structure;Structure of jugular vein;Syndrome;System;Testing;Thrombin;Thrombosis;Thromboxanes;Thrombus;Time;traumatic event;Traumatic injury;VAMP-2;Vascular System;Venous;venule;Visualization;von Willebrand factor receptor;wound;Wound models

PROJECT_TITLE: Resubmission: Structure/Function Determinants of Puncture Wound Thrombus Formation