NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Epilepsy;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Anti-seizure medications (ASMs) are commonly prescribed to older adults, who often have co-occurring neurodegenerative disease. Although older adults with seizures are expected to be more sensitive to cognitive and other ASM adverse effects, knowledge gaps have resulted in a lack of medication prescribing guidance in this population. Under the guidance of my mentors, I will examine current use and comparative safety of ASMs (with special attention to cognitive decline) in older adults with and without Alzheimer’s Disease and related dementias and contribute to the evidence necessary to inform prescribing guidance by determining key decision- making factors in the context of ASM prescription in older adults with seizures.

PI_NAMEs: BLANK, LEAH  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Adult;Adverse effects;Age;Aging;aging related;Alzheimer's disease related dementia;Anticonvulsants;Applied Skills;Attention;Attitude;Award;Behavior Therapy;Behavioral;Benzodiazepines;Biometry;care coordination;career;caregiver education;Caring;Central Nervous System;Clinical;Clinical Trials;Cognition;Cognitive;cognitive change;cognitive function;cognitive reserve;cohort;Cohort Studies;comorbidity;comparative;comparative safety;Data;Decision Making;Dementia;dementia care;demographics;design;Development;Disease;Dose;Drug Monitoring;Drug Prescriptions;Emergency Medicine;Epilepsy;Evaluation;evidence base;Evidence based treatment;experience;follow-up;Foundations;frailty;Frequencies;gabapentin;Generations;Geriatrics;Goals;Guidelines;Health and Retirement Study;health literacy;Health Services;Health Services Research;human old age (65+);Impaired cognition;improved;Insurance;Internal Medicine;Intervention;Knowledge;Laboratories;Learning;Levetiracetam;Link;Longitudinal Surveys;medical specialties;Medicare;Medication Systems;Mentors;Mentorship;mild cognitive impairment;Modeling;Monitor;multi-component intervention;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurologist;Neurology;older adult;Outcome;Patient Education;Patients;Pharmaceutical Preparations;Pharmacoepidemiology;Physical Function;Physiological;Population;Positioning Attribute;pregabalin;Prevalence;Primary Care;programs;Provider;Qualitative Methods;Quality Indicator;Quality of life;Randomized, Controlled Trials;Reaction;Recommendation;recruit;Recurrence;Research Methodology;Research Personnel;Resources;Risk;Safety;Sampling;Science;Sedation procedure;Seizures;Severities;skills;Socioeconomic Status;Subgroup;success;support tools;System;Testing;Therapeutic;therapy development;Titrations;Training;Translating;treatment strategy;Vertebral column;Work

PROJECT_TITLE: Seizure, cognitive change and dementia: Understanding the use and safety of anti-seizure medications

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PASADENA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: Project Narrative  The computational and synthetic development of methods for spirocycle synthesis and alkene hydroamination provide the opportunity to access a diverse array of medicinally privileged scaffolds and new chemical structures. The establishment of a Ni-catalyzed, intramolecular addition reaction of enolates to nitriles is anticipated to generate functionalized spirocyclic lactones, which are present in various natural products and bioactive molecules. Additionally, the discovery of a strategy for the hydroamination of trisubstituted alkenes using NHC borane chemistry will produce a variety of functionalized nitrogen-containing heterocycles.

PI_NAMEs: RAMIREZ, MELISSA  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TITLE: Methods for Enantioselective Spirocycle Synthesis and Radical Hydroamination of Trisubstituted Alkenes


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Genetics;Hematology;Human Genome;Kidney Disease;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE IgA vasculitis is an understudied pediatric disorder that often leads to serious complications, including kidney failure. The exact pathogenic mechanisms of IgAV remain unclear, leading to the general lack of targeted treatments and preventive strategies. This proposal aims to identify genetic determinants of IgAV to provide unbiased insights into the disease pathogenesis and enable prioritization of potential targets for new drug development.

PI_NAMEs: LIU, LILI  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 19q13;1q21;2q37.1;Address;Adult;Affect;Asian ancestry;Autoimmune Diseases;Autoimmunity;Award;Blood;Blood Vessels;career;career development;case control;causal variant;cell type;Cells;Child;Childhood;Chromosome Mapping;Clinical;Clinical Data;cohort;Communicable Diseases;Complex Genetic Trait;Data;Data Set;Deposition;Detection;Development;Disease;drug development;drug repurposing;East Asian;End stage renal failure;Ethnic Origin;European;Foundations;functional genomics;Funding;Gastrointestinal tract structure;Gene Expression;Gene Expression Regulation;gene function;gene regulatory network;Genes;Genetic;genetic analysis;genetic architecture;Genetic Determinism;Genetic Medicine;Genetic Predisposition to Disease;Genetic study;genetic variant;genome wide association study;genome-wide;Genomics;Goals;Health;Hematuria;Henoch-Schoenlein Purpura;HLA-DRB1;Human;Human Genetics;IgA receptor;Immune;Immune Targeting;Immunoglobulin A;Immunologics;improved;Individual;Inflammatory;insight;Interleukin 6 Receptor;Joints;K-Series Research Career Programs;Kidney;Kidney Diseases;Kidney Failure;Knowledge;Maps;Mediating;Mentors;Mentorship;Meta-Analysis;Modeling;Molecular Medicine;multidisciplinary;Multiomic Data;Nephrology;new therapeutic target;novel;Organ;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patients;peripheral blood;Population Analysis;population based;precision medicine;prevent;Prevention;Prevention strategy;Proteinuria;Proteome;Quantitative Trait Loci;reconstruction;Regulator Genes;Research;Research Personnel;Research Training;Resources;Risk;risk variant;RNA Splicing;Signal Transduction;skill acquisition;Skin;Spliced Genes;Susceptibility Gene;System;Systems Biology;Testing;therapeutic target;tocilizumab;Training;trait;transcriptome;transcriptomics;Translations;treatment strategy;Universities;Variant;Vasculitis;Work

PROJECT_TITLE: Uncovering novel mechanisms and potential therapeutic targets for IgA vasculitis through GWAS and systems-level analysis of regulatory networks.

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Obesity;Physical Activity;Physical Rehabilitation;Prevention;Prostate Cancer;Rehabilitation;Urologic Diseases

ORG_CITY: RICHMOND

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Cardiovascular disease is a primary competing cause of morbidity and mortality among older men diagnosed with prostate cancer, especially those treated with androgen deprivation therapy. Behavioral interventions to support the adoption and maintenance of exercise training may be a promising non-pharmacological approach to buffer the negative sequalae of treatment with ADT. Through the proposed research and training plan we will test whether a behavioral exercise training intervention, that can be remotely delivered to men across diverse settings, leads to favorable changes in exercise capacity, body composition and subclinical markers of cardiovascular function, that forecast future cardiovascular events.

PI_NAMEs: LUCAS, ALEXANDER RUSSELL (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Acceleration;Activities of Daily Living;Address;Adoption;Aerobic Exercise;Age;androgen deprivation therapy;arm;Behavior Therapy;Behavioral;Body Composition;Buffers;Cancer Center;Cancer Patient;Cancer Survivor;Cardiac;cardiac magnetic resonance imaging;Cardiac Output;Cardiopulmonary;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;career;career development;Clinic;Clinical Trials;Communities;comparison control;Conduct Clinical Trials;coronary fibrosis;Data;design;Development Plans;Diagnosis;disorder risk;Dropout;Education;Educational Intervention;effective intervention;Effectiveness;Environment;Event;evidence base;Exercise;exercise capacity;exercise intervention;exercise intolerance;exercise prescription;exercise program;Exercise Test;exercise training;experience;Fatigue;Fatty acid glycerol esters;Functional disorder;Future;future implementation;Geography;Goals;Guidelines;Health;health care availability;Health education;health related quality of life;Heart failure;heart function;high risk;Home;human old age (65+);Imaging Techniques;Impairment;improved;Individual;insight;Intervention;intervention effect;intervention refinement;Interview;Intramuscular;intraperitoneal;lean body mass;Learning Module;Left;Magnetic Resonance;Maintenance;male;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medical center;men;Mentored Research Scientist Development Award;Mentors;Metabolic;Metabolic syndrome;Methodology;Methods;Morbidity - disease rate;mortality;Muscle;muscle form;Musculoskeletal;Musculoskeletal System;Myocardial dysfunction;Nonpharmacologic Therapy;novel;Obesity;older men;Outcome;outcome prediction;Oxygen;Participant;Patients;Peripheral;Physical activity;Physical Function;Population;preservation;programs;prostate cancer risk;Prostate Cancer therapy;Qualifying;Race;Randomized;recruit;remote delivery;Research;Research Design;Research Personnel;Research Project Grants;resistance exercise;Sampling;Skeletal Muscle;skills;strength training;Structure;Surveys;Symptoms;Testing;therapy design;Training;Training Programs;treatment effect;Treatment Side Effects;United States Department of Veterans Affairs;Venous;Ventricular;vigorous intensity;Virginia;Walking;Work

PROJECT_TITLE: Behavioral Exercise Training to Reduce Cardiovascular Disease Risk in Men Undergoing Androgen Deprivation Therapy

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative There is urgent need for new approaches to treat obesity, diabetes, and cardiovascular disease. The full potential of activating fat tissue that can burn rather than store energy has not been realized. This application will further advance our knowledge in this field by investigating a protein, Perilipin 5, that can help boost the burning of fat and improve blood sugar control in mice with diet-induced obesity.

PI_NAMEs: BICKEL, PERRY E (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Adipocytes;Adipose tissue;Adrenergic Agonists;Adult;Affect;Agonist;Alleles;Attention;Biogenesis;Blood Glucose;Body Weight Changes;Body Weight decreased;Brown Fat;cancer risk;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Catecholamines;Cell Nucleus;Cell Size;cold stress;Crista ampullaris;Cyclic AMP-Dependent Protein Kinases;Diabetes Mellitus;diet-induced obesity;Distal;Dose;Doxycycline;Economic Burden;energy balance;Energy Metabolism;Event;experimental study;Family;fat burning;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;feeding;Foundations;Funding;gain of function;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Glucose Intolerance;glucose metabolism;glucose tolerance;Goals;Health;healthspan;High Fat Diet;Histology;Human;Hypertrophy;Image;improved;in vivo;inflammatory marker;insight;Insulin;insulin sensitivity;Intervention;Knock-out;Knowledge;lipid metabolism;Lipids;Lipolysis;Literature;Liver;loss of function;LoxP-flanked allele;Mediating;member;Metabolic;Metabolic Diseases;Metabolic Pathway;Mitochondria;Modeling;mouse model;Mouse Strains;Mus;mutant;Non obese;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;novel therapeutic intervention;novel therapeutics;Nuclear;Obese Mice;Obesity;obesity treatment;Outer Mitochondrial Membrane;oxidation;perilipin;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Physiological;Prevalence;prevent;Prevention;programs;Proteins;Publishing;Pyruvate;rational design;Regulation;Research;Respiration;response;Risk Factors;Role;Signal Pathway;Signal Transduction;SIRT1 gene;Structure;Surface;synergism;Testing;Therapeutic;Thermogenesis;Tissues;uptake;Weight;Weight maintenance regimen;Work

PROJECT_TITLE: Perilipin 5 in the Regulation of Adipose Tissue Function

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Disparities in healthcare access, insurance coverage, and socioeconomic burdens fuel barriers to primary care especially among patients at highest risk for undiagnosed diabetes. This study seeks to identify risk factors for not being able to follow-up for a new diagnosis of diabetes in the emergency department and improve linkage of these newly diagnosed patients to appropriate outpatient care. This study will help improve diabetes surveillance by transforming the emergency department into an effective clinical setting that can help screen the millions of high-risk patients that visit emergency departments across the United States each year, thereby reducing disparities in glycemic control and the frequency of diabetic complications.

PI_NAMEs: LEE, DAVID C (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Accident and Emergency department;Address;Age;Algorithms;Ambulatory Care;American;Asian;barrier to care;Belief;Black race;Blood;Blood Pressure;Blood Tests;care seeking;Caring;Cessation of life;Characteristics;Chronic Disease;Clinical;Communities;comorbidity;Complications of Diabetes Mellitus;Country;Data;data registry;Diabetes Mellitus;diabetes risk;Diagnosis;Disease;Disparity in diagnosis;disparity reduction;Economic Burden;electronic health data;Electronic Health Record;Emergency Care;Emergency Department patient;Emergency department screening;Emergency department visit;ethnic minority;Face;follow-up;Frequencies;glycemic control;Glycosylated hemoglobin A;Health;health care availability;health care disparity;health disparity;Health Personnel;Health Services Accessibility;Healthcare Systems;High Prevalence;high risk;Hispanic;improved;Income;Individual;Insurance;Insurance Coverage;Intervention;Interview;Latino;Link;machine learning method;male;Minority;Modeling;Neighborhoods;Newly Diagnosed;Outcome;Outpatients;pandemic disease;Patient Care;Patient-Focused Outcomes;Patients;Persons;Phenotype;poor health outcome;Poverty;Predisposing Factor;Prevalence;Preventive care;Primary Care;primary care clinic;primary care provider;primary care visit;racial minority;Radiology Specialty;Randomized, Controlled Trials;Recommendation;Recording of previous events;Research;Research Methodology;Risk Factors;Sampling;screening;Shapes;Social support;socioeconomics;Sorting;statistics;Structure;Subgroup;Symptoms;System;telehealth;Telemedicine;Testing;Time;United States;Visit;Work

PROJECT_TITLE: Identifying Risk Factors for Poor Glycemic Control among Emergency Department Patients and Improving Linkage to Outpatient Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-P(90)S]


NIH_SPENDING_CATS: Cystic Fibrosis;Genetics;Lung;Orphan Drug;Rare Diseases

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: CHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative. Several recently approved therapeutics have revolutionized the treatment of cystic fibrosis, which is a common genetic disease caused by a spectrum of mutations within the CFTR gene. However, the optimal combination of drugs for each patient depends on the nature of their specific genetic variations, and the optimal therapeutic combinations have yet to be determined for the hundreds of known CF mutations. The proposed investigations will utilize a combination of emerging techniques to comprehensively match current medications to these mutations and help to target new drugs as they come to market.

PI_NAMEs: PLATE, LARS ;SCHLEBACH, JONATHAN PATRICK (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Affect;airway epithelium;Autophagocytosis;Binding Sites;Biochemical;Biogenesis;Caucasians;Cells;Classification;Clinical;Cluster Analysis;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Combined Modality Therapy;Computing Methodologies;CRISPR/Cas technology;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Defect;Delta F508 mutation;Disease;Drug Combinations;drug discovery;drug efficacy;Eligibility Determination;Epithelial Cells;Exhibits;FDA approved;functional restoration;Genetic;Genetic Diseases;Genetic Variation;Genotype;Goals;Human;improved;In complete remission;Inbred F344 Rats;Industry Standard;Investigation;Ion Channel;Knock-out;Label;Link;loss of function mutation;Machine Learning;Marketing;Measurement;Measures;Medical;Methods;Modeling;Molecular Chaperones;molecular modeling;molecular phenotype;monolayer;Mutation;mutation screening;Nature;new therapeutic target;novel;novel strategies;Patients;personalized intervention;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Population;predicting response;Property;protein structure;Proteins;Proteomics;proteostasis;rare variant;Refractory;Regulator Genes;Residual state;response;Shapes;small molecule;Structural defect;Structural Models;Surveys;System;targeted treatment;Techniques;Testing;Therapeutic;Thyroid Gland;tool;trait;Validation;Variant;variant of unknown significance;Work

PROJECT_TITLE: Rational optimization of combinatorial therapies for the treatment of rare cystic fibrosis variants

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention;Telehealth

ORG_CITY: LOS ANGELES

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The goal of this proposal is to apply machine learning approaches to multiple data sources including electronic health record data, high-fidelity physiological waveform data, and genomic data that have never been used together in the acute care setting to predict postoperative major complications and decrease failure-to-rescue after surgery. These inputs will be used in simulated real-time bedside management to 1) iteratively design a prototype clinical decision support tool and 2) evaluate its use in simulation upon use of postoperative continuous remote monitoring and early warning systems, accuracy and time to correct diagnosis, accuracy of intervention, and time-to-intervention. The feasibility and acceptability of this clinical decision support tool will then be assessed in a small-scale prospective, longitudinal pilot evaluation in sequential 10-weeks, 13-weeks, 10-weeks phases to help design a future, large-scale clinical trial.

PI_NAMEs: CANNESSON, MAXIME  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: acceptability and feasibility;Acute;acute care;Acute Kidney Failure;Acute Renal Failure with Renal Papillary Necrosis;algorithm training;Ambulatory Surgical Procedures;American;analytical tool;Anesthesia procedures;Arrhythmia;Atlases;biobank;Cardiovascular system;Caring;Cause of Death;Clinical;clinical decision support;Clinical effectiveness;Clinical Trials;Data;Data Set;Data Sources;data streams;Databases;Decision Making;deep neural network;design;Deterioration;Development;Diagnosis;Early Diagnosis;effective therapy;effectiveness evaluation;Electronic Health Record;Equity;ergonomics;Etiology;Evaluation;Failure;Future;genomic data;Genomics;Genotype;Goals;health information technology;Heart Arrest;hemodynamics;Hemorrhage;high risk;Hospital Mortality;Hospitalization;Hospitals;Hour;Hypotension;improved;Incidence;indexing;inpatient surgery;Inpatients;Intensive Care Units;Intervention;Intraoperative Monitoring;iterative design;Kidney;large datasets;lung failure;Machine Learning;machine learning algorithm;machine learning model;Medical Errors;model development;Modeling;Monitor;mortality;multimodal data;multiple data sources;Myocardial Infarction;neural network algorithm;novel;older patient;Operative Surgical Procedures;Outcome;patient oriented;Patients;Pattern;Perioperative;personalized risk prediction;Persons;Phase;Physiological;Population;Postoperative Period;prediction algorithm;predictive tools;pressure;prevent;Prevention;Procedures;prospective;prototype;Provider;Pulmonary Embolism;Recommendation;remote monitoring;Repeat Surgery;Resource Allocation;Resources;Risk;risk prediction;Sepsis;simulation;smart environment;Specificity;Subgroup;support tools;surgical risk;System;Techniques;Technology;Testing;Time;Training;Validation;Variant;ward;whole genome

PROJECT_TITLE: Personalized Risk Prediction for Prevention and Early Detection of Postoperative Failure to Rescue

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(02)M]


NIH_SPENDING_CATS: Biotechnology;Cooley's Anemia;Genetics;Hematology;Human Genome;Rare Diseases;Sickle Cell Disease

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Cis-regulatory elements (CREs) play an important role in the regulation of β-like globin expression. We have identified novel CRE hubs downstream of β globin gene cluster could regulate the γ globin expression. We propose to use comprehensive genome and epigenome editing strategy to dissect the function of these CREs in β-like globin gene expression under various scenarios.

PI_NAMEs: ZHANG, XIAOTIAN  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: 3-Dimensional;Adult;beta Globin;beta Thalassemia;Binding;Binding Sites;Categories;Cell Line;Cells;Chromatin;Classification;Code;CRISPR/Cas technology;Data;Development;Dimerization;Disease;Dissection;EEF1A2 gene;Enhancers;Environment;EP300 gene;epigenome editing;epigenomic profiling;Erythrocytes;Erythroid;Erythroid Cells;Erythropoiesis;experimental study;fetal;Fetal Hemoglobin;gamma Globin;GATA1 gene;Gene Cluster;Gene Expression;Gene Expression Regulation;gene therapy;gene-targeted therapy;Generations;Genes;Genetic;Genetic Diseases;Genome;genome editing;genomic locus;Genomic Segment;Genomics;Globin;Hemoglobin;Hemoglobin F Disease;Hemoglobinopathies;Histones;Human;Human Genome;Locus Control Region;Mediating;Molecular Target;mutant;novel;novel strategies;Pathogenicity;Play;Point Mutation;Population;precise genome editing;prime editing;progenitor;promoter;Proteins;Publishing;reduce symptoms;Regulation;Regulatory Element;Research;Role;Sequence Deletion;Sickle Cell Anemia;Site;Structure;System;Technology;Thalassemia;therapy development;tool;transcription factor;Transcriptional Regulation;Twin Multiple Birth;Untranslated RNA;Up-Regulation;Update;Work

PROJECT_TITLE: The dissection of non-canonical cis-regulatory elements downstream of beta-globin locus in the fetal hemoglobin gene regulation

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Physical Activity;Prevention;Sleep Research;Social Determinants of Health;Telehealth

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This research will provide the first evidence regarding the immediate and sustaining efficacy of an mHealth- facilitated physical activity intervention on cognitive function and sleep in low-income older adults, a population that experiences multiple social inequalities and health disparities and at high risk for Alzheimer’s disease. It will add scientific knowledge on whether physical activity impacts Amyloid/Tau/ Neurodegeneration (ATN) biomarkers and whether sleep and ATN biomarkers underline the effect of physical activity on cognitive function. If successful, the findings will support clinicians and the public to engage low-income older adults in physical activity for better sleep and cognitive health.

PI_NAMEs: LI, JUNXIN  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: actigraphy;Address;Adherence;age stratification;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Biological;Biological Markers;Cognition;Cognitive;cognitive benefits;cognitive function;cognitive testing;Communities;comparison control;computerized;Control Groups;Dementia;design;Electroencephalography;Empirical Research;Episodic memory;executive function;Exercise;exercise intervention;experience;flexibility;General Population;Goals;Health;health disparity;high risk;high risk population;Home;Home visitation;Hour;Impaired cognition;improved;Individual;Inequality;innovation;Intervention;Knowledge;lifestyle intervention;Light;Location;Low income;Measures;Mediating;Memory;mHealth;Monitor;Motivation;Nerve Degeneration;neurofilament;older adult;Outcome;Outcome Measure;Participant;Patient Self-Report;Physical activity;physical inactivity;Pilot Projects;Plasma;Play;poor sleep;Population;Randomized;Randomized, Controlled Trials;Research;response;Risk Factors;Rodent;Role;Schedule;sedentary;sedentary lifestyle;sex;Sleep;Sleep disturbances;sleep health;sleep spindle;Sleeplessness;Slow-Wave Sleep;social disparities;Structure;Subgroup;Symptoms;tau Proteins;tau-1;Telephone;telephone coaching;Testing;Time;Training;trend;usability;wearable device;Work

PROJECT_TITLE: mHealth-Facilitated Physical Activity Toward Health (mPATH) for Cognitive Function and Sleep in Low-Income Older Adults

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Broadly neutralizing antibodies are a necessary component of an effective HIV vaccine, but an incomplete understanding of broadly neutralizing antibody development has impeded attempts to elicit these desirable antibody responses via vaccination. Here, I use high-throughput mutational scanning techniques to elucidate the molecular evolutionary forces and constraints that guide HIV antibody development. These detailed mutational maps will enable the design of improved HIV vaccine immunogens and therapeutic antibodies and reveal the general principles of broadly neutralizing antibody function and development with relevance for various pathogens where broad antibody responses are necessary for pathogen control.

PI_NAMEs: STARR, TYLER NELSON (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: 2019-nCoV;Address;Amino Acids;Antibodies;Antibody Affinity;Antibody Response;Antibody Therapy;Antigens;Autologous;autoreactivity;Binding;Binding Sites;Biochemical;Biological Assay;biophysical properties;Biophysics;CD4 Antigens;Cessation of life;Chiroptera;Chronic;Clinical;computational suite;Coronavirus;Creativeness;Data;Data Set;design;Development;env Gene Products;Evolution;experimental study;Funding Opportunities;global health;HIV;HIV Antibodies;HIV envelope protein;HIV Infections;HIV vaccine;Immune;Immunity;improved;Infection;innovation;insight;Maps;Measures;Methodology;Methods;Molecular;Molecular Evolution;Mutation;mutation screening;natural antibodies;neutralizing antibody;novel;pandemic virus;pathogen;Pathway interactions;Patients;Pharmaceutical Preparations;Polysaccharides;Postdoctoral Fellow;pressure;Preventive vaccine;Prognosis;programs;Property;prophylactic;Prophylactic treatment;rational design;Research;skills;small molecule;Specificity;Structure;Techniques;Therapeutic;Therapeutic antibodies;Thermodynamics;tool;Training;Vaccination;vaccine candidate;Vaccine Design;vaccine development;vaccine-induced antibodies;Vaccines;Variant;Viral;Virus;Yeasts

PROJECT_TITLE: The evolutionary landscape of HIV broadly neutralizing antibody development


ADMINISTERING_IC: HD

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Fragile X Syndrome;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Rare Diseases;Social Determinants of Health

ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Fragile X Syndrome (FXS) is an inherited, lifelong neurodevelopmental disorder that results in significant health and functional impairments; however, the great majority of knowledge about FXS derives from research on children, leaving adulthood a vast uncharted territory. In this proposed renewal, we will investigate FXS during adulthood and we will evaluate how the family and social contexts are associated with more favorable health and behavioral functioning during this life stage. We will leverage two distinct and rich data sources– electronic health records drawn from a racially and ethnically diverse population of 15 million patients in the Chicago area which includes 368 adults (age 18 to 80+) with FXS, and a separate longitudinal cohort of adults with FXS and their premutation carrier mothers (n=182 dyads) with up to 8 repeated measures over the 18- year period.

PI_NAMEs: DAWALT, LEANN SMITH (contact);MAILICK, MARSHA RUTH;MOVAGHAR, AREZOO

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Age;age related;Age Years;Area;autism spectrum disorder;Behavioral;burden of illness;case control;Cessation of life;CGG repeat expansion;Chicago;Child;clinical phenotype;Code;cohort;Communication;Comparative Study;contextual factors;cost;Data;Data Sources;design;Development;Diagnosis;Diagnostic;Disease;diverse data;early childhood;Educational Status;electronic health data;Electronic Health Record;emerging adult;ethnic diversity;Ethnic Origin;executive function;Familial disease;Family;family burden;Family member;Family Relationship;FMR1 gene;FMR1 Premutation;Fragile X Premutation;Fragile X Syndrome;Functional impairment;Generations;Goals;Health;health care service utilization;health determinants;health difference;Health Insurance;Healthcare Systems;human old age (65+);Income;Individual;Inherited;innovation;Intellectual functioning disability;Investigation;Knowledge;Life;Life Cycle Stages;Longitudinal cohort;longitudinal design;Measures;Medical;Medical Records;men;Methods;middle age;Mothers;mutation carrier;Neighborhoods;Neurodevelopmental Disorder;Nucleotides;older adult;Outcomes Research;Parenting Education;Parents;Participant;patient health information;Patient-Focused Outcomes;Patients;Phase;Population Heterogeneity;Problem behavior;programs;prospective;Prospective Studies;Province;Public Health;Race;racial diversity;recruit;Research;Risk;Sampling;Services;sex;skills;Social Environment;Societies;sociodemographic factors;Socioeconomic Status;Stressful Event;Subgroup;Symptoms;Testing;US State;Woman;X Chromosome

PROJECT_TITLE: Adults with Fragile X Syndrome: Health and Life Course Trajectories

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Spectacular growth in data and scalable computing represents a tremendous opportunity to create a more diverse environmental health community trained in data science principles. We propose the creation of a short course in Data Science for Environmental Public Health that combines online learning and an in-person project-focused intensive, with special consideration for participants from institutions serving underrepresented learners. Through our experience in massively scalable education, we will create a complementary online course equivalent, interactive online community, and materials aimed at instructors who want to bring this course to other institutions, empowering a broad array of potentially thousands of environmental health scientists to improve their research with data science tools.

PI_NAMEs: HOFFMAN, AVA MARIE (contact)

PROGRAM_OFFICER_NAME: GARTON, AMANDA E

PROJECT_TERMS: Address;Applied Skills;Awareness;Big Data;Cancer Center;Code;Collaborations;Communities;community building;community college;Community Health;Companions;Continuing Education;Data;Data Analyses;Data Science;data science education;Data Set;Democracy;Development;Discipline;Disparity;Documentation;E-learning;Education;Education Gap;Educational Materials;Educational process of instructing;empowerment;Environmental Health;Environmental Science;Ethics;Event;experience;Faculty;Feedback;flexibility;Foundations;Goals;Growth;health data;health disparity;health equity;Hispanic-serving Institution;Historically Black Colleges and Universities;Home;improved;Individual;Institution;Instruction;instructor;Lead;Learning;learning materials;lectures;massive open online courses;Minority-Serving Institution;Modeling;multimodality;online community;online course;Participant;participant retention;peer;peer support;Persons;programs;Public Health;Publishing;recruit;Reproducibility;Research;Research Personnel;Resources;Science;Scientist;Services;skills;success;supportive environment;Teacher Professional Development;Technology;Time;tool;Training;Travel;tribal college;Work

PROJECT_TITLE: Short Course in Data Science for Environmental Public Health


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Kidney Disease;Organ Transplantation;Transplantation

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Today, approximately 15% of the adult population in the United States live with chronic kidney disease (CKD), some of which will need dialysis or transplant. Home dialysis and pre-emptive transplant, compared to in- center dialysis, may be better for patients for numerous reasons. This research seeks to understand if patients’ capacity predicts their choice of dialysis, ability to stay on that type of dialysis, or their access to transplant.

PI_NAMEs: BOEHMER, KASEY  (contact)

PROJECT_TERMS: Adult;Affect;American;Applied Skills;Award;Biography;Blood;Caring;Cessation of life;Chronic;Chronic Kidney Failure;Clinical;clinical care;clinical predictive model;clinically relevant;comorbidity;coping;cost effective;Diagnosis;Dialysis procedure;Eligibility Determination;Emotional;Environment;Epidemiology;Evaluation;experience;Funding;Goals;Health;health care service utilization;Health Professional;Healthcare;Hemodialysis;Home;hospice environment;Immunosuppression;implementation science;Information Systems;Intervention;Isoantibodies;Kidney;Kidney Failure;Kidney Transplantation;Life;Measures;Medical;Methods;Modality;Modeling;Obesity;observational cohort study;Outcome;Patient Noncompliance;patient oriented;Patient Selection;Patients;Population;prognostic;programs;prospective;psychosocial;Quality of life;Renal Replacement Therapy;Research;Research Personnel;Resources;Risk;Role;Self Care;Shoulder;skills;social;Social Network;Statistical Models;Testing;Training;Transplant Recipients;Transplantation;United States;United States Dept. of Health and Human Services;Veins;Waiting Lists;Work;Workload

PROJECT_TITLE: The Role of Patient Capacity in Chronic Kidney Disease Trajectories


NIH_SPENDING_CATS: Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emergency Care;Health Services;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Unintentional Childhood Injury

PHR: PROJECT NARRATIVE Pediatric injuries are a leading cause of morbidity and mortality in children worldwide. This K23 Career Development Award will develop and pilot test a health systems intervention to streamline the triage process (e.g. patient assessment, stabilization, and disposition), and improve time to definitive care and outcomes of pediatric injury patients. By completing the proposed research and training plans with the support of her multi- disciplinary mentorship team, Dr. Keating seeks to create a scalable intervention to address a critical public health challenge while launching an independent career as a Pediatric Emergency Medicine physician- scientist.

PI_NAMEs: KEATING, ELIZABETH MARIE (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Africa South of the Sahara;Assessment tool;Award;career;career development;Caring;Cessation of life;Child;Childhood;Childhood Injury;Clinical Investigator;Clinical Trials;Clinical Trials Design;Communities;Complex;Consolidated Framework for Implementation Research;Data;Dedications;disability;District Hospitals;Educational workshop;Effectiveness;Emergency Medicine;Emergency Situation;Ensure;Evaluation;Evaluation Research;evidence base;experience;Feedback;Fellowship;Focus Groups;formative assessment;Foundations;Future;global health;Goals;Health;Health care facility;Health Personnel;Health Services Accessibility;Health system;Hospital Referrals;Hour;implementation context;implementation evaluation;implementation framework;implementation intervention;implementation outcomes;implementation science;improved;improved outcome;Infrastructure;injured;Injury;innovation;Interdisciplinary Study;International;Intervention;intervention refinement;Interview;K-Series Research Career Programs;Knowledge;low and middle-income countries;Medical;Medical center;Mentors;Mentorship;Methods;Morbidity - disease rate;mortality;multi-component intervention;multidisciplinary;National Institute of Child Health and Human Development;novel;Outcome;Patients;pediatric emergency;pediatric patients;pediatric trauma;Physicians;pilot test;Positioning Attribute;Prevention;Process;Public Health;Qualitative Methods;Quality of Care;Registries;Research;Research Personnel;Resource-limited setting;responsible research conduct;Risk Assessment;Scientist;Site;skills;Strategic Planning;success;System;Tanzania;Techniques;therapy development;Time;tool;Training;Trauma;Trauma Research;Traumatic injury;Triage;United States National Institutes of Health;Work

PROJECT_TITLE: P-KIDs CARE: An Intervention to Address Health Systems Delays to Care for Injured Children in Tanzania

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ORG_CITY: FAYETTEVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: Project Narrative Defects in epithelial morphology contribute to a wide range of human pathologies, including birth defects, cancer, impaired wound healing, and inflammation, so therefore, a primary focus of developmental biology has been to uncover the mechanisms that control epithelial cell shape. Studies of epithelial tissue elongation and wound healing have shown that Toll family receptors and mitochondria are critical players in the regulation of tension and adhesion at the cell membrane, although the molecular links between these processes are still being uncovered. This proposal will address how signaling by Toll receptors and mitochondrial networks interact to drive cell shape change during tissue elongation––revealing how biomechanics and bioenergetics are coordinately regulated during embryonic development and shedding light on how these processes are misregulated in disease states.

PI_NAMEs: PARE, ADAM CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Actomyosin;Address;Adhesions;Affect;Animals;Antibodies;Architecture;Area;Atlases;Attention;Bioenergetics;Biomechanics;Cell Adhesion Inhibition;cell behavior;Cell membrane;Cell Polarity;Cell Shape;Cell-Cell Adhesion;Cells;Cellular Metabolic Process;Cellular Morphology;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Complex;Congenital Abnormality;convergent extension;CRISPR/Cas technology;Cytoskeleton;Data;Defect;Development;Developmental Biology;Disease;Drosophila genus;Embryo;Embryonic Development;Embryonic Structures;Engineering;Epithelial Cells;epithelial wound;Epithelium;experimental study;Family;Fluorescence;fluorescence lifetime imaging;functional loss;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gain of function;Genetic;Genetic Techniques;Genome engineering;Genomics;GPCR Signaling Pathway;Health;Homeostasis;Human;Human Pathology;Immune signaling;Impaired wound healing;in vivo;Individual;Inflammation;Intercalated Cell;intercalation;Label;Light;Link;loss of function;Malignant Neoplasms;Measures;Mediator;member;Metabolic;Metabolism;Microscopy;Mitochondria;model organism;Modeling;Molecular;Morphology;Multiphoton Fluorescence Microscopy;multiphoton microscopy;Mutation;Myosin ATPase;NADH;Nature;Neoplasm Metastasis;Neuroectoderm;Oxidation-Reduction;Pathway interactions;Pattern;Play;Positioning Attribute;Process;Production;Proteins;receptor;Receptor Activation;receptor expression;receptor function;Receptor Gene;Receptor Signaling;Regulation;rho;Rho-associated kinase;Role;seal;Shapes;Signal Pathway;Signal Transduction;Stereotyping;Structure;Study models;System;Techniques;Tertiary Protein Structure;Testing;Tissues;Toll-like receptors;Transgenic Organisms;tumor;Visualization;wound healing

PROJECT_TITLE: Control of epithelial morphology and bioenergetics by Toll receptors during dynamic tissue remodeling

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Drug Abuse (NIDA only);Estrogen;HIV/AIDS;Infectious Diseases;Methamphetamine;Neurodegenerative;Neurosciences;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_CITY: GRAND FORKS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PHR: Project Narrative The prevalence of HIV-associated neurocognitive disorders (HAND) remains high even with antiretroviral therapy, and there exists sex-differences in HAND; However, the underlying mechanisms remain elusive. The proposed studies are focused to determine the protective effect of 17α-estradiol, the predominant form of estrogen in brain, against brain damage resulting from combined exposure of HIV-1 viral proteins (gp120 and Tat), antiretroviral drugs, and methamphetamine. Findings are expected to provide novel insights into sex-differences in HAND and provide new targets and rationale for preventative and therapeutic interventions against HAND.

PI_NAMEs: CHEN, XUESONG  (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Affect;Anti-Retroviral Agents;antiretroviral therapy;Axon;Brain;Brain Injuries;Cognition;Cognitive deficits;comorbidity;Complex;Dendritic Spines;density;Development;drug of abuse;ESR1 gene;Estradiol;Estrogens;Evaluation;Female;Functional disorder;gray matter;Hippocampus;HIV;HIV Envelope Protein gp120;HIV-1;HIV-associated neurocognitive disorder;Impaired cognition;Impairment;In Vitro;in vivo Model;insight;knock-down;Learning;male;Membrane;Methamphetamine;Methamphetamine misuse;mutant;Neurocognitive Deficit;Neuronal Plasticity;Neurons;neuroprotection;novel;overexpression;Pathogenesis;Pharmaceutical Preparations;Play;Prevalence;prevent;preventive intervention;Process;Production;protective effect;Protein Isoforms;Proteins;Rattus;Role;Sex Differences;Site;Solid;stimulant misuse;stimulant use;Testing;Therapeutic;Therapeutic Intervention;trafficking;Viral Proteins;Woman;Work

PROJECT_TITLE: 17α-estradiol and sex-differences in HAND with methamphetamine

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Acute kidney injury is a common kidney disease, often found in critically ill patients, which is induced such as by sudden cardiac arrest or by side effects from a chemotherapeutic agent. A dire consequence of acute kidney injury is progression to chronic kidney disease, which accounts for approximately 6.7% of all Medicare expenditure. This study will combine the use of cultured kidney cells with genetically modified mouse models and pharmacological approaches to investigate whether a gene termed VEGF-R2 plays an important role in acute kidney injury to chronic kidney disease progression.

PI_NAMEs: CHIBA, TAKUTO GRECO (contact)

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;adeno-associated viral vector;Age;Attenuated;Blood Vessels;cell injury;Cell Separation;Cells;chemotherapeutic agent;Chronic Kidney Failure;Cisplatin;Coculture Techniques;Critical Illness;Data;Dependovirus;Disease;disease model;Disease Progression;Endothelial Cells;Endothelium;etomoxir;Expenditure;experimental study;Faculty;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Female;Gene Modified;Genes;Heart Arrest;Heterogeneity;Home;Human;In Situ Hybridization;In Vitro;Inflammation;Inflammatory;inhibitor;Injury;Injury to Kidney;innovation;KDR gene;Kidney;kidney cell;Kidney Diseases;Knock-out;Knockout Mice;loss of function;male;Mediating;Medicare;Medicine;Mentored Research Scientist Development Award;Mentors;Mesenchymal;Methods;Mitochondria;Modeling;Molecular;mouse model;Mus;Myofibroblast;Nature;Pathway interactions;Patients;PDH kinase;Pericytes;pharmacologic;Phenotype;Platelet-Derived Growth Factor;Play;Population;Predictive Factor;preservation;Process;Production;programs;PTPRJ gene;recruit;renal ischemia;repaired;Reperfusion Injury;Reporter;Research;Respiration;Risk;Role;sex;side effect;Signal Transduction;single-cell RNA sequencing;Small Interfering RNA;Source;Tamoxifen;Testing;Therapeutic;therapeutic evaluation;therapy development;Thrombospondin 1;transcriptome sequencing;Universities;Validation;Volatile Fatty Acids

PROJECT_TITLE: The role of maladaptive VEGFR2 signaling in renal stroma for chronic kidney disease


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Machine Learning and Artificial Intelligence;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE Most patients with neovascular age-related macular degeneration (AMD) need eye injections every 1-3 months for the remainder of their lives. This study will contribute to our understanding of a novel immune-mediated mechanism involved in neovascular AMD that is associated with incomplete response to treatment.

PI_NAMEs: HOUTMAN, JON C.D.;SOHN, ELLIOTT H (contact);SONKA, MILAN

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age related macular degeneration;Angiography;Antigen-Presenting Cells;antigen-specific T cells;Area;Artificial Intelligence;automated algorithm;Bite;Blindness;Blood specimen;Blood Vessels;Cell Culture Techniques;Cells;Cellular biology;Characteristics;chemokine;Choroid;Choroidal Neovascularization;Clinic;cohort;Collaborations;Complement Factor H;cytokine;Data;Dendritic Cells;Disease;Elderly;Epitope Mapping;Epitopes;experience;Exudative age-related macular degeneration;Eye;Fibrosis;Frequencies;Gelatinase B;Gene Expression;Genes;Genetic;genetic variant;genomic locus;Genomics;Genotype;health economics;Helper-Inducer T-Lymphocyte;high risk;Human;Image;Image Analysis;Immune;immune activation;Immune response;Immunologic Techniques;Immunology;immunomodulatory therapies;improved;Individual;Inflammatory;inhibitor;Injections;innovation;Learning;Liquid substance;Longitudinal cohort;Machine Learning;Mediating;Mediator;multidisciplinary;Mutation;neovascular;new therapeutic target;novel;novel therapeutic intervention;Nucleic Acid Regulatory Sequences;Optical Coherence Tomography;Pathway interactions;Patients;Peptides;Phenotype;Physiological;Play;polarized cell;preservation;profiles in patients;Proteins;Research;Research Personnel;response;Retina;retinal imaging;retinal prosthesis;Risk;risk variant;Signal Transduction;single-cell RNA sequencing;Societies;socioeconomics;Strategic Planning;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic Intervention;Tissues;Training;translational impact;Treatment Factor;Treatment Protocols;treatment response;Validation;Variant;Vascular blood supply;Vascular Endothelial Growth Factors;Vision;Visual Acuity;Visualization;Weaning

PROJECT_TITLE: MMP-9 based immune-driven mechanisms of neovascular AMD

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Diabetes;Digestive Diseases;Neurosciences;Nutrition;Obesity;Prevention

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE This proposal is focused on the development of a novel concept of obesity and associated metabolic disorders in that a single molecule can reduce appetite, body weight and blood glucose, while protecting critical pancreatic cells from further damage, by simultaneously acting through multiple target pathways. Our group has identified several peptides that act on the receptors for glucagon-like peptide-1, neuropeptide Y1, and neuropeptide Y2, which show very promising results in pairing strong reduction of food intake and body weight with improved glucose metabolism. The goal of the proposed study is to understand the mechanisms of improved pharmacology and drug safety, to identify mechanisms leading to reduced body weight and improved glucoregulation, and to provide novel candidates including long-acting drug candidates.

PI_NAMEs: DOYLE, ROBERT P;ROTH, CHRISTIAN LUDWIG (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Acute;Adipose tissue;Adult;Adverse effects;Agonist;Albumins;analog;Appetite Depressants;Area;behavior test;Beta Cell;beta-arrestin;Binding;Blood Glucose;Body Weight;Body Weight Changes;Body Weight decreased;Brain;Brain Stem;Calories;Cell Nucleus;Cells;Central Nervous System;Characteristics;Chronic;Clinical;comorbidity;Complement;Deoxyglucose;Desire for food;Development;Diabetes Mellitus;diabetic;diabetic rat;diet-induced obesity;Disease;Distress;Dose;drug action;drug candidate;Drug Kinetics;Eating;energy balance;Energy Intake;Energy Metabolism;exenatide;experience;Family;Fasting;Food Preferences;FOS gene;Functional disorder;Gastric Emptying;gastric inhibitory polypeptide receptor;gastrointestinal;Generations;GLP-I receptor;Glucagon;glucagon-like peptide 1;Glucose;Glucose Clamp;glucose metabolism;glucose uptake;Goals;hindbrain;Homeostasis;Hormones;Hyperinsulinism;Hypothalamic structure;improved;In Vitro;in vivo evaluation;Injections;innovation;Insulin;insulin secretion;insulin sensitivity;Intake;interest;Intervention;intravenous glucose tolerance test;Islets of Langerhans;Label;Lead;liraglutide;Long-Term Effects;Malaise;Mediating;medication safety;Mentored Clinical Scientist Development Program;Metabolic;Metabolic Diseases;monomer;Morbidity - disease rate;mortality;Mus;Muscle;Nausea;neuropeptide Y2 receptor;Neuropeptides;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;obesity treatment;Outcome;Pain;Pancreas;Pathway interactions;Patient Compliance;Penetration;peptide analog;Peptide YY;Peptides;Peripheral;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacology;Positioning Attribute;Proteolysis;Publishing;Quality of life;Rattus;receptor;recruit;reduced food intake;Regulation;Research;Research Personnel;response;Rodent;Shrews;side effect;Signal Transduction;single molecule;Skeletal Muscle;Stains;Structure of alpha Cell of islet;Structure of area postrema;success;synergism;targeted treatment;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Thinness;Tissues;transcriptomics;transdifferentiation;Visceral;Vomiting

PROJECT_TITLE: Development of Anorexigenic and Glucoregulatory Chimeric Peptides

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Immunization;Infectious Diseases;Vaccine Related;Vector-Borne Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health since it focuses on understanding the immune evasion mechanism deployed by the human pathogen Schistosoma mansoni. Completion of the proposed study will bring new insights to how schistosomes operate inside the human host and identify potential targets for future therapeutic design that could aid in combating schistosomiasis.

PI_NAMEs: LEE, JAYHUN  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Affect;Anterior;Atlases;Binding;Biological Assay;Biology;Blood;Blood Circulation;Candidate Disease Gene;cell type;Cells;Cessation of life;chemotherapy;comparative;Complement;Coupled;Cytolysis;Cytoplasm;Data;design;Development;Endowment;Ensure;Environment;esophageal gland;Esophagus;Exons;feeding;fighting;forkhead protein;Future;Gastrointestinal tract structure;Genes;Gland;Goals;Heterogeneity;Homeostasis;Human;human pathogen;Immune;Immune Evasion;Immune system;Immunocompromised Host;Immunoglobulins;In Situ Hybridization;In Vitro;in vivo;Individual;Ingestion;innovation;insight;interest;knock-down;Leukocytes;Link;Maintenance;Mass Spectrum Analysis;Mediating;Molecular;Mus;new therapeutic target;novel;Organ;Parasites;Penetration;Physiologic pulse;Platyhelminths;Play;Praziquantel;prevent;protein function;Proteins;Public Health;Publishing;Research;RNA Interference;Role;Schistosoma;Schistosoma mansoni;Schistosomiasis;Site;Skin;stem cells;Therapeutic;therapeutic target;Tissue atlas;Tissues;transcriptome sequencing;transcriptomics;Transplantation;Vaccines;Work

PROJECT_TITLE: Esophageal gland-mediated immune evasion by the human parasite Schistosoma mansoni

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Hematology;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: PROJECT NARRATIVE The goal of this proposal is to elucidate the role of EGFL7 in the biology of acute Graft versus Host disease (aGVHD) and developed therapeutic strategies to target this protein. At completion of this project, we will have an increased understanding of the role of EGFL7 in aGVHD and incorporate these findings into future treatment strategies that may improve overall outcomes.

PI_NAMEs: DORRANCE, ADRIENNE M.;GARZON, RAMIRO  (contact);RANGANATHAN, PARVATHI

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Acute Graft Versus Host Disease;Address;Adhesions;Affect;Allogenic;angiogenesis;Apoptosis;Biology;Blood Vessels;Cell Adhesion;Cell Adhesion Molecules;cell motility;Cell Physiology;Cell Proliferation;Cells;Clinical;Complication;cytokine;cytotoxic;Data;Dendritic Cells;Disease;disease model;Dose;E-Selectin;Endothelial Cells;Endothelium;Epidermal Growth Factor;Epithelium;Extravasation;Future;Goals;graft vs leukemia effect;Growth Factor;Hematologic Neoplasms;Hematological Disease;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Homologous Transplantation;Immune;immune reconstitution;improved;Inbred BALB C Mice;Inflammation;Inflammatory;Intercellular adhesion molecule 1;Interferon Type II;Intestines;knockout animal;Large Intestine;Liver;loss of function;Maximum Tolerated Dose;migration;Morbidity - disease rate;mouse model;Mus;neurogenesis;novel therapeutic intervention;novel therapeutics;Outcome;Patients;pharmacokinetics and pharmacodynamics;Phenotype;Physiological;Play;preclinical study;prevent;Proliferating;Proteins;Publishing;Recombinants;reconstitution;Refractory;repaired;Repression;response;Role;Schedule;Severities;Severity of illness;Stem cell transplant;stem cells;Steroids;T cell infiltration;T-Cell Activation;T-Lymphocyte;Therapeutic;thymocyte;Tissues;TNF gene;Toxic effect;Toxicology;Transplant Recipients;Transplantation;treatment strategy;Vascular Cell Adhesion Molecule-1;vasculogenesis

PROJECT_TITLE: Developing novel therapies to improve blood stem cell transplantation outcomes

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Atherosclerosis;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Nutrition;Obesity;Patient Safety;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW ORLEANS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative In the proposed study, we will test whether a community health worker-led church-based multifaceted implementation strategy for applying the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease will reduce cardiovascular health disparities in African Americans in New Orleans and Bogalusa, Louisiana. The proposed study will generate evidence on effectiveness, implementation, and sustainability of multifaceted interventions aimed at eliminating cardiovascular health disparities in high-burden populations in the US.

PI_NAMEs: FERDINAND, KEITH COPELIN;HE, JIANG ;MILLS, KATHERINE TERESA (contact)

PROGRAM_OFFICER_NAME: KHAN, SHAHNAZ

PROJECT_TERMS: Address;Adoption;Adult;African American;African American population;aged;Atherosclerosis;atherosclerosis risk;Black church;Blood Pressure;blood pressure reduction;Body mass index;Body Weight decreased;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;Caring;Cause of Death;Cholesterol;Church;Clinical;Clinical Research;Clinical Trials Data Monitoring Committees;Cluster randomized trial;Communities;community advisory board;Community Health Aides;community setting;Control Groups;cost;cost effectiveness;Cost Effectiveness Analysis;Data;Development;Diet;Education;Educational Materials;Effectiveness;effectiveness outcome;effectiveness testing;effectiveness/implementation design;Elements;Ensure;Evaluation;Exercise;Feedback;follow-up;Follow-Up Studies;General Population;geographic disparity;Glucose;Goals;good diet;group intervention;Guidelines;Health;Health behavior;health care availability;health disparity;Health Personnel;Health Promotion;Healthcare Systems;high risk;implementation evaluation;implementation outcomes;implementation process;implementation strategy;improved;inner city;Institutional Review Boards;Intention;Intervention;intervention program;Intervention Studies;Knowledge;Life Style;Louisiana;Manuals;Medical;medication compliance;member;Monitor;multi-component intervention;Needs Assessment;never smoking;Outcome;Outcome Study;Participant;patient oriented;Penetrance;Phase;Physical activity;pilot test;Population;post intervention;Prevention Guidelines;primary outcome;Primary Prevention;Procedures;Process Measure;Protocols documentation;Provider;Public Health;racial disparity;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recommendation;recruit;Research;Risk Factors;rural African American;scale up;Side;Smoking;Social Environment;socioeconomics;Testing;Training;treatment as usual;Unhealthy Diet;unhealthy lifestyle;United States National Institutes of Health;vigorous intensity;Visit;Weight;weight loss program;Work

PROJECT_TITLE: Community Health Worker-Led Church-Based Intervention for Eliminating Cardiovascular Health Disparities in African Americans


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Aurora

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE This proposal examines the neural basis for how decisions about movements are optimized by recent experiences. Our findings will offer insight into fundamental brain function and will contribute to improving treatments for neurological conditions in which decision making and movements are impaired.

PI_NAMEs: FELSEN, GIDON S (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Animals;Bayesian Modeling;Brain;Brain region;Cell Nucleus;cell type;cholinergic;Contralateral;Cues;Data;Decision Making;Exhibits;experience;experimental study;Goals;Impairment;improved;insight;Left;Location;Mediating;Midbrain structure;Modeling;Motor;motor impairment;Motor Neurons;Motor output;Movement;Mus;Nervous System Physiology;neural;neural circuit;Neurologic;Neurons;Odors;optogenetics;Outcome;Output;Pedunculopontine Tegmental Nucleus;Positioning Attribute;Recording of previous events;Rewards;Role;Sensory;Stimulus;superior colliculus Corpora quadrigemina;System;Testing;theories;transmission process;Uncertainty;Variant;Water

PROJECT_TITLE: Neural circuits for adaptively biasing decision making

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Aging;Diabetes;Nutrition;Obesity

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Adipose tissue is a critical endocrine mediator of metabolic health that is functionally altered during aging and obesity. Our preliminary data demonstrate that dietary protein restriction (DPR) improves metabolic health and remodels adipose tissue. This application tests the hypothesis that the remodeling of adipose tissue during dietary protein restriction directly improves metabolic health during aging.

PI_NAMEs: HILL, CRISTAL MONIQUE (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: adipocyte biology;Adipocytes;adiponectin;Adipose tissue;Age;age related;aged;Aging;Animals;Appearance;Bioinformatics;Biology;Biology of Aging;biomedical profession;blood glucose regulation;Brain;Cell Culture Techniques;Data;Dietary Proteins;dietary requirement;Endocrine;Energy Intake;Energy Metabolism;Fatty acid glycerol esters;fibroblast growth factor 21;Genetic Models;Genetic Transcription;Geroscience;graduate student;Health;Hormone secretion;Hormones;Impairment;improved;Inflammation;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;Knowledge;life span;Longevity;Mediating;Mediator;Metabolic;Metabolic hormone;Metabolism;Methodology;Methods;Modeling;Molecular;mouse genetics;Mus;novel;Obesity;obesity risk;old mice;Outcome;physiologic model;Postdoctoral Fellow;Procedures;protein intake;Protein-Restricted Diet;Proteins;Publishing;Regulation;Research;response;Risk Factors;Scientist;Signal Pathway;Signal Transduction;Techniques;Testing;Tissue Grafts;Tissue Transplantation;training opportunity;transcription factor;transcriptome sequencing;Work

PROJECT_TITLE: Dietary Protein Restriction Remodels Adipose Tissue to Defend Against Age-Related Metabolic Decline

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Neurosciences;Nutrition

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Project Narrative / Relevance Gastroparesis is a disorder of gastric function characterized by delay in gastric emptying, frequently associated with chronic nausea and vomiting, early satiety, postprandial fullness, abdominal pain, and malnutrition that may require nutritional support. There are few effective treatments available; more recently, a procedure called G-POEM (gastric peroral endoscopic myotomy) has been advocated to relieve symptoms by improving gastric emptying. However, it is not clear whether this is safe or effective. The primary aim of this pilot and feasibility, hypothesis-generating study therefore is to evaluate the effect of peroral endoscopic pyloromyotomy (G- POEM) vs. sham endoscopic surgery on symptoms in patients with diabetic or idiopathic gastroparesis.

PI_NAMEs: CAMILLERI, MICHAEL L.;PASRICHA, PANKAJ J (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Abdominal Pain;Acceleration;Adverse effects;Advocate;Age;Agonist;antagonist;Antral;Area;Attention;Black Box;Body mass index;Botulinum Toxins;Chronic;Cicatrix;Clinic;Clinical;Clinical Research;cost;Data;Demographic Factors;demographics;Denervation;Devices;Diabetes Mellitus;diabetic;Diagnosis;Diameter;Diet therapy;Disease;Dopamine;early satiety;effective therapy;efficacious treatment;Electric Stimulation;Enteral;Etiology;excitatory neuron;experience;Factor Analysis;Functional disorder;Future;Gastric Emptying;gastric retention;Gastrointestinal Motility;gastrointestinal symptom;Gastroparesis;Giant Cells;improved;in vivo;inhibitory neuron;Interstitial Cell of Cajal;Macrophage;Malnutrition;Measures;Mechanics;Metoclopramide;Motility;motility disorder;Motor;Nausea;Nausea and Vomiting;Neurologic;Neuropathy;novel;Nutritional Requirements;Nutritional Support;Obstruction;Operative Surgical Procedures;Opioid Analgesics;Outcome;outcome prediction;panacea;Pathogenesis;Pathology;Patient Selection;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physiological;Physiology;Placebos;predicting response;premature;pressure;Procedures;prospective;Psychological Factors;Pyloric sphincter structure;Pylorus;Questionnaires;Randomized;Randomized, Controlled Trials;reduce symptoms;Refractory;Registries;Reporting;Resistance;Running;Safety;Severities;sham surgery;Solid;Stents;Stomach;symptomatic improvement;Symptoms;Syndrome;Testing;tool;treatment effect;treatment optimization;Uncertainty;Uncontrolled Study;Universities;Vomiting

PROJECT_TITLE: A randomized control trial of G-POEM for gastroparesis to assess feasibility, safety, efficacy and physiological mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hearing Loss;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: LITTLE ROCK

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

PHR: PUBLIC HEALTH RELEVANCE School-based health programs often provide the only access to preventive services for underserved rural children, but loss to follow-up and limited numbers of specialists are problematic. This study will prospectively  evaluate a new model of school-based, telehealth-driven preventive care (STAR) in Appalachian schools of rural  eastern Kentucky to reduce loss to follow-up from school hearing screening and improve access to specialty care in rural environments. This telehealth-driven model could be applied to a wide range of preventable health  disparities and translated to other underserved populations across rural America.

PI_NAMEs: BUSH, MATTHEW LEE;EMMETT, SUSAN DAVIS (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Achievement;acute care;Address;Adoption;Advocacy;Appalachian Region;barrier to care;Caring;Child;Childhood;childhood hearing loss;Clinic;Cluster randomized trial;Communities;community advisory board;community engagement;community-level factor;Consolidated Framework for Implementation Research;County;design;digital;Disparity;Disparity population;Education;effectiveness evaluation;effectiveness/implementation trial;Employment;evidence base;Female;follow-up;Friends;Funding;Future;Goals;Health;health care model;health disparity;Health Services Accessibility;Health system;Health Technology;Healthcare;hearing impairment;hearing screening;Home;Hybrids;implementation determinants;implementation facilitators;implementation outcomes;implementation science;Improve Access;improved;Inequality;Infection;Infrastructure;innovation;insight;Intervention;Kentucky;kindergarten;Language Development;Lead;Letters;Life;Life Cycle Stages;Location;medical specialties;meetings;mHealth;Minority;model generalizability;Modeling;multidisciplinary;novel;Parents;Pathway interactions;Policies;Policy Analysis;Population;Preventive care;Preventive Health Services;Preventive service;Primary Care;primary outcome;programs;prospective;prototype;public health relevance;Randomized;randomized trial;Reduce health disparities;Research;Rural;rural Alaska;rural America;rural area;Rural Community;rural counties;rural environment;rural health disparities;rural underserved;scale up;school health;School Nursing;Schools;screening;screening policy;Screening procedure;Shapes;social determinants;social health determinants;socioeconomic disadvantage;Specialist;State Government;teacher;Technology;telehealth;telehealthcare;Telemedicine;Testing;therapy design;Time;Translating;treatment as usual;Tribes;underserved community;Underserved Population;United States National Institutes of Health;virtual;virtual technology;Work

PROJECT_TITLE: Appalachian STAR Trial


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This project will fill a critical gap in the research infrastructure to develop and test novel measures and methods for evaluation of clinically meaningful outcomes of psychosocial interventions to enhance living fully with dementia. Persons living with dementia, interdisciplinary researchers and clinicians will combine expertise in the R21 phase to develop research guidelines that will improve the quality and range of outcome measures available to innovators, researchers and providers. New measures will be pilot tested in the R33 phase.

PI_NAMEs: ZIMMERMAN, SHERYL  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acceleration;Agitation;Assisted Living Facilities;Behavior;Behavior Therapy;Behavioral;care seeking;Clinical;Clinical Trials;Cognitive;Collaborations;collaboratory;Communities;Complex;Data Set;Dementia;dementia care;design;Development;Diagnosis;Dissemination and Implementation;Elements;Evaluation;experience;Face;Family;functional loss;Goals;Guidelines;Home environment;human centered design;improved;Individual;Infrastructure;infrastructure development;innovation;instrument;Intervention;Intervention Studies;Intervention Trial;Measurement;Measures;Methods;novel;Numeric Rating Scale;Nursing Homes;optimism;Outcome;Outcome Measure;Patient Preferences;Patient Self-Report;person centered;Personal Satisfaction;Persons;Phase;Pilot Projects;pilot test;pragmatic trial;Prevention;prototype;Provider;psychosocial;psychosocial outcome;Quality of life;Readiness;Research;research clinical testing;Research Infrastructure;Research Methodology;Research Personnel;response;Sensory;Site;Standardization;Symptoms;Technology;Testing;Therapeutic;Time;trial design;United States;United States National Institutes of Health;Validation;Validity and Reliability;Work

PROJECT_TITLE: Holistic Evaluation to Advance Research in Dementia (HEARD): Phased Interdisciplinary Infrastructure Development and Pilot Studies

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Telehealth

ORG_CITY: WORCESTER

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: WORCESTER POLYTECHNIC INSTITUTE

ORG_STATE: MA

PHR: Inaccuracies in SpO2 measurement have come under scientific scrutiny during and after the pandemic. An  active public engagement discusses the consequences on people of color. The known design flaw of SpO2  measurements must be corrected to bring justice and equity. Relying on the fact that PaO2 is the primary  determinant of SaO2 in the blood and our multimodal sensor can measure the direct surrogates of these  parameters, this opportunity allows us to exploit concurrent measurements of these parameters to develop  a unique approach to mitigate racial bias in oxygenation measurements.

PI_NAMEs: GULER, ULKUHAN  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Admission activity;Adverse effects;Algorithms;Binding;Biomedical Research;Biosensing Techniques;Blood;Blood gas;Clinical;clinical practice;Collection;connected health;COVID-19;Custom;Data;Data Set;design;Diffusion;Ecosystem;Effectiveness;Electronics;Equity;Event;Female;Gases;Goals;Gold;graduate student;Hemoglobin;Home;improved;improved outcome;individualized medicine;infant monitoring;International;Journals;Justice;Knowledge;Life;Literature;Lung;Machine Learning;Measurement;Measures;Medical;Medicine;Methods;Miniaturization;miniaturize;Modality;Monitor;monitoring device;multimodality;Neonatal Intensive Care Units;neonate;novel;Outcome;Outpatients;Oxygen;Oxygen Therapy Care;pandemic disease;Partial Pressure;Patients;people of color;Pigmentation physiologic function;Play;Process;PtcO2;racial bias;readmission risk;recruit;remote assessment;remote monitoring;remote patient monitoring;Research;Research Personnel;Resolution;Resources;respiratory;Respiratory Disease;Respiratory distress;Role;Sensitivity and Specificity;sensor;sensor technology;signal processing;Skin;skin color;SMART health;symposium;Time;time use;Transcutaneous Blood Gas Monitoring;treatment planning;undergraduate student;Validation;wearable device;Work

PROJECT_TITLE: SCH: A Novel Bias-mitigated Multimodal Oxygen Monitor


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Networking and Information Technology R&D (NITRD);Prevention;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: Boston

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: PROJECT NARRATIVE The prevalence of mobile telephony in sub-Saharan Africa (SSA) creates an opportunity for the adoption of mobile technology for monitoring and control of hypertension, the most prevalent NCD risk factor. We propose to study the usability and feasibility of a Ghana-adapted, evidence-based mHealth platform to improve self-care and management of hypertension in an urban and rural region of Ghana. Capacity building initiatives include the formation of a research and education network to accelerate mHealth research in Ghana.

PI_NAMEs: KOOMSON, VALENCIA JOYNER (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Acceleration;Adherence;Adoption;Affect;Africa South of the Sahara;Ally;Appointment;arm;Blood Pressure;blood pressure control;Cardiac;Cardiology;Cardiovascular Diseases;Cardiovascular system;Caring;Cellular Phone;Chronic Disease;Clinic;Clinical;clinical care;cohort;Collaborations;Communication;Communities;Computer software;Computers;COVID-19 pandemic;Data;Death Rate;Devices;Diabetes Mellitus;digital;Disease;disorder risk;Economic Burden;Education;Effectiveness;empowerment;Engineering;Event;evidence base;Evidence based intervention;Feasibility Studies;Feedback;Focus Groups;Ghana;Health;health empowerment;health literacy;Health Promotion;Health Services;Healthcare;Healthcare Systems;high risk population;Hypertension;hypertension control;hypertensive;improved;Institution;Intervention;Interview;Israel;iterative design;Knowledge;Life;low and middle-income countries;Malignant Neoplasms;Measurement;Measures;Medical center;Medical Device;Methods;mHealth;mhealth interventions;mobile application;mobile computing;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Myocardial Infarction;Network Infrastructure;Organ;Outcome;Participant;Patient Self-Report;patient-clinician communication;Patients;Persons;Pharmaceutical Preparations;Phase;Policies;Population Study;Prevalence;Process;programs;Provider;provider communication;Public Health;remote patient monitoring;Reporting;Research;Research Personnel;Research Project Grants;Risk;Risk Factors;rural area;rural patients;Schedule;Science;Scientist;Self Care;Site;Stroke;Surgeon;Surveys;System;Target Populations;Teaching Hospitals;Technology;technology development;technology intervention;Testing;Text Messaging;tool;treatment adherence;treatment planning;Universities;urban area;usability;user centered design;Validation;Vulnerable Populations;wireless network;World Health Organization

PROJECT_TITLE: AHOMKA: A Culturally-adapted mHealth Platform for Management of Hypertension in an Urban and Rural Region of Ghana


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: This application will provide urgently needed analytical methods to support high-resolution imaging genetics network analyses with the focus on major neuropsychiatric disorders. SOLAR- Eclipse is an integrated suite of resources for genetic and epigenetic analyses such as heritability, pleiotropy, high-resolution genome-wide association (GWA) and Whole-Genome Analyses (WGA), gene expression, quantitative trait loci-linkage (QTL-L) and methylation analyses optimized for traits derived from structural and functional neuroimaging data.

PI_NAMEs: KOCHUNOV, PETER V. (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Adult;Advisory Committees;Algorithms;analytical method;application programming interface;Big Data;biobank;Brain;Brain imaging;BRAIN initiative;cell type;Cells;Censuses;Cerebral cortex;Cerebrum;Charge;Cognition;Cognitive;Cognitive deficits;Collaborations;Combinatorics;Complex;Computer software;computerized tools;connectome;Data;Data Analyses;data format;data sharing;Dependence;Development;Diagnosis;Dimensions;Disease;Drug resistance;Epigenetic Process;Equilibrium;Etiology;Evaluation;Family;Funding;Gene Expression;gene regulatory network;Genes;Genetic;genetic analysis;genetic resource;genetic risk factor;GENIE;genome analysis;genome wide association study;Graph;graph theory;Heritability;high resolution imaging;Human;Hybrids;Image;imaging genetics;improved;Individual;innovation;International;Knowledge;large datasets;Link;Linkage Disequilibrium;Magnetic Resonance Imaging;Manuscripts;Mediation;Meta-Analysis;Methods;Methylation;Modernization;Network-based;neuroimaging;neuroinformatics;neuropsychiatric disorder;Nicotine Dependence;novel;Pathway Analysis;Pathway interactions;Pattern;Performance;Phase;Phenotype;pleiotropism;processing speed;Publications;Pythons;Quantitative Trait Loci;Resolution;Resources;Running;Sampling;Schizophrenia;screening;Short-Term Memory;software development;Statistical Methods;Structure;Testing;tool;trait;United States National Institutes of Health;Update;white matter;whole genome

PROJECT_TITLE: Solar-Eclipse Computational Tools for Imaging Genetics

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Immunotherapy

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Despite remarkable clinical success of immune checkpoint blockade in a range of cancers, most colorectal cancer (CRC) patients do not respond to these treatments. Using powerful new mouse models of CRC and cutting-edge tools in immunology, I propose to deeply investigate T cell dysfunction programmed by suboptimal priming. This project aims to delineate mechanisms of efficacy and resistance to therapies targeting the T cell priming axis, with the goal of guiding clinical investigation of novel combination immunotherapies for CRC.

PI_NAMEs: WESTCOTT, PETER MAXWELL KIENITZ (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Ablation;Antigens;ATAC-seq;Binding;Biological;Biological Assay;Cancer Etiology;cancer infiltrating T cells;Cancer Model;Candidate Disease Gene;CD8-Positive T-Lymphocytes;Cessation of life;chemokine;Chromatin;Clinical;clinical investigation;Clinical Trials;Colon;colon cancer patients;Colon Carcinoma;Colonoscopy;Colorectal Cancer;Combination immunotherapy;CRISPR/Cas technology;cytokine;Data;Data Set;Development;engineered T cells;ERG gene;exhaustion;flexibility;Flow Cytometry;Foundations;Functional disorder;Genes;genetic signature;Genetic Transcription;Goals;Human;immune checkpoint;immune checkpoint blockade;Immune Evasion;Immune response;immunoengineering;Immunology;Immunotherapy;in vivo;innovation;Investigation;K22 Award;Knock-out;Knowledge;lymph nodes;Malignant Neoplasms;Mediator;Memory;Microsatellite Instability;Microsatellite Repeats;Modeling;Molecular;mouse model;Mutation;neoantigens;novel;novel therapeutic intervention;NR4A1 gene;NR4A2 gene;Nuclear Orphan Receptor;Organoids;Phenotype;Play;pre-clinical;Pre-Clinical Model;preclinical trial;Process;Productivity;programs;Publications;Publishing;Receptor Signaling;Refractory;Renal Carcinoma;Research;research clinical testing;Resistance;resistance mechanism;responders and non-responders;Role;single cell sequencing;single-cell RNA sequencing;small molecule inhibitor;Solid Neoplasm;success;T cell differentiation;T cell infiltration;T cell response;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;therapy resistant;Tissues;TNFRSF5 gene;tool;trafficking;Training;transcriptome sequencing;transplant model;treatment responders;treatment response;tumor;Tumor Escape;tumor microenvironment;Tumor-Derived;Vaccination;Viral Cancer;Virus Diseases;Work

PROJECT_TITLE: Mechanisms and strategies to rescue suboptimal T cell priming in colon cancer


NIH_SPENDING_CATS: Infectious Diseases;Microbiome

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Lipid mediators are major signaling molecule constituents in all kingdoms of life, and bacteria produce bioactive lipid mediators that are not made by mammalian cells. Inflammation in the intestine or sites of bacterial infections exemplifies the immune response to agonistic bacterial lipid mediators, but some bacteria also produce lipid countermeasures, such as hydroxy fatty acids, that can suppress the inflammatory response. This project will elucidate the immune signaling pathways that respond to hydroxy fatty acids to suppress immune responses and the biosynthetic pathways by which commensal and pathogenic bacteria release hydroxy fatty acids.

PI_NAMEs: RADKA, CHRISTOPHER DAVID (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Anti-Inflammatory Agents;anti-microbial drug;Area;Arrestins;Attenuated;Bacteria;Bacterial Infections;Bifidobacterium;Binding;Biochemical;Biochemistry;Biological Assay;biophysical techniques;career;CD1 Antigens;Cell Culture Techniques;Cells;commensal bacteria;Complement;Coupled;Cryoelectron Microscopy;cytokine;design;drug discovery;Encapsulated;Environment;Enzymes;experimental study;extracellular;extracellular vesicles;Fatty Acids;Flow Cytometry;Foundations;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gastrointestinal;Genetic Transcription;Goals;gut inflammation;gut microbiome;Homologous Gene;human pathogen;Hydration status;hydroxy fatty acid;Hydroxylation;Immune;Immune Evasion;Immune response;Immune signaling;Immunologics;Immunologist;Immunology;immunoregulation;Immunosuppression;Infection;Infectious Skin Diseases;Inflammation;Inflammatory Response;inhibitor;Innate Immune Response;Innate Immune System;Instruction;Intercept;interest;Intestines;Invaded;Investigation;Knock-out;Laboratories;Lead;Life;Ligand Binding;lipid mediator;lipid metabolism;Lipids;Lipopolysaccharides;Lipoproteins;Luciferases;Mammalian Cell;Measures;Mediating;Mediator;Membrane;Mentors;Modeling;Modification;Molecular;Molecular Conformation;multidisciplinary;Mus;novel;Oleates;Organism;pathogen;Pathogen detection;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Pattern;Pertussis Toxin;Phase;Phospholipids;pi bond;Play;Productivity;programs;receptor;Receptor Activation;Receptor Cell;Receptor Signaling;recruit;Reporter;Reporting;Research;response;Roentgen Rays;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Soft Tissue Infections;Staphylococcus aureus;structural biology;Structure;Symbiosis;System;T cell response;T-Cell Activation;T-Cell Receptor;Techniques;Testing;Tissues;TLR2 gene;Toll-like receptors;Training;Unsaturated Fatty Acids;Vesicle;vesicular release;Virulence

PROJECT_TITLE: Bacterial anti-inflammatory lipid mediators


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Regulatory changes made during the COVID-19 public health emergency (PHE) that relaxed criteria for take- home dosing (THD) of methadone offer an opportunity to improve retention in care with a lifesaving treatment. Black/African American and Latinx clients are disproportionately affected by more restrictive THD rules than non-Latinx White clients. We will develop and test the effects of a data-informed intervention to increase THD best practices in programs that dispense methadone for treatment of opioid use disorders.

PI_NAMEs: BAO, YUHUA ;JORDAN, ASHLY ELIZABETH;NEIGHBORS, CHARLES J (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: addiction;Address;administrative database;Adverse event;adverse outcome;Affect;African American;Attitude;Behavior;Belief;Black race;Businesses;Caring;Categories;Client;Clinic;Clinical;clinical decision-making;clinical practice;cohort;Communities;Confusion;Connecticut;COVID-19;dashboard;Data;Databases;design;Development;Dimensions;Dose;Emergency department visit;Ethnic Origin;Event;experience;flexibility;health care disparity;health equity;Healthcare;Home;Hospitalization;Iatrogenesis;implementation framework;improved;Incentives;Individual;Intervention;intervention effect;intervention program;intervention refinement;Interview;Latinx;Latinx population;Leadership;Legal Liability;Life;Medicaid;medication for opioid use disorder;Methadone;methadone treatment;Methods;Modeling;Monitor;mortality;New York;Not Hispanic or Latino;opioid treatment program;opioid use disorder;Outcome;Overdose;payment;Persons;Pharmaceutical Preparations;Phase;programs;public health emergency;Quality of life;Race;Randomized;randomized trial;Recording of previous events;Registries;Regulation;Relaxation;Reporting;Research;Safety;Services;stem;Stigmatization;System;Testing;Universities;Variant;Visit;waiver

PROJECT_TITLE: Leveraging regulatory flexibility for methadone take-home dosing to improve retention in treatment for opioid use disorder: A stepped-wedge randomized trial to facilitate clinic level changes


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative Every time cells divide, their DNA is damaged at a low level. This “endogenous” DNA damage is an important factor in normal and aberrant animal development, but because it happens at a low level over long time periods it hasn’t been possible to study in detail. I propose to develop a new tool with the resolving power to study endogenous DNA damage and other rare cellular processes over weeks to months in developing mammals.

PI_NAMEs: LOVELESS, THERESA BERENS (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Affect;Animals;Architecture;Biological;Cell Cycle;Cell Physiology;Cells;Characteristics;Collection;Cultured Cells;Development;DNA;DNA Damage;DNA damage checkpoint;Dose;Engineering;Event;experience;experimental study;Genes;genetically modified cells;Genome;Genome Stability;genomic locus;in vivo;Insertion Mutation;interest;Lead;Life;Long-Term Effects;Longitudinal Studies;Malignant Neoplasms;Mammals;Molecular;Monitor;mouse model;Mutation;new technology;novel strategies;Nucleotides;Optics;patient derived xenograft model;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phenotype;Physiological;Population;promoter;Proteins;Recording of previous events;Records;Resistance;response;RNA;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Techniques;Technology;Testing;Therapeutic;Time;tissue culture;tool;Transgenic Mice;triple-negative invasive breast carcinoma;Work;Writing;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Deep cell history tracking: engineering cells that write their detailed life stories into their DNA to study DNA damage


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Alzheimer’s disease dementia is typically associated with memory loss and accumulation of amyloid plaques, but a majority of individuals actually show mixed pathological changes in the brain, which are often associated with worse outcomes and cognitive decline than in individuals with only amyloid pathology. Unfortunately, the influence of these additional changes on disease severity and progression is poorly understood, largely because we still lack mouse models that recapitulate these additional pathologies, particularly in the presence of comorbidities relevant to human health and disease. Our objective here is to, for the first time, create models of Alzheimer’s disease and its related dementias that more accurately capture the complexity of this devastating disease in humans.

PI_NAMEs: DUNN, AMY ;KACZOROWSKI, CATHERINE COOK;O'CONNELL, KRISTEN M (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Algorithmic Analysis;alpha synuclein;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;amyloid pathology;Animal Model;Atlases;Basic Science;behavior test;Behavioral;Blood Vessels;Brain;Cells;Cerebral Amyloid Angiopathy;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;Cognitive deficits;cognitive testing;cohort;combinatorial;Communities;comorbidity;Complex;Computer software;Coupled;CRISPR/Cas technology;Data;data resource;Databases;Dementia;Diagnosis;Diet;Dimensions;Disease;Disease Progression;disease-causing mutation;disorder risk;drug discovery;Early identification;Elderly;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Exhibits;familial Alzheimer disease;feature detection;Fertility;Frontotemporal Dementia;functional genomics;Funding Mechanisms;gene conservation;Gene Expression Profile;gene network;Genetic;Genetic Variation;genome editing;genomic data;Health;Heterogeneity;hippocampal sclerosis;Human;human data;human disease;human model;Image;image processing;Impaired cognition;improved;Individual;Informatics;insight;Knock-in;Knock-in Mouse;late life;Late Onset Alzheimer Disease;Lewy Body Dementia;life span;Magnetic Resonance Imaging;Measurement;Memory Loss;mimetics;mixed dementia;model development;Modeling;Molecular;molecular phenotype;mouse genetics;mouse model;Mus;Mutation;network models;neurobehavioral;Neurodegenerative Disorders;neuroimaging;Neurologic;neuropathology;neurotoxic;new therapeutic target;next generation;novel;Outcome;Pathogenesis;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Patients;Pattern;Peripheral;Phase;phenome;Phenotype;phenotypic data;Physiological;Population;Positioning Attribute;preclinical study;Preclinical Testing;Predisposition;Process;programs;protein TDP-43;repository;Reproducibility;resilience;Resources;response;Rest;Risk;risk variant;RNA;Role;Route;screening;Selection Criteria;Senile Plaques;Severity of illness;sex;Staging;Structure;Symptoms;Synapses;synucleinopathy;tau Proteins;therapeutic development;Time;Tissues;transcriptome sequencing;Translating;Translations;United States National Institutes of Health;Variant;Vascular Dementia;Viral;western diet

PROJECT_TITLE: Alzheimer's Disease-Related Dementia Models by Precision Editing and Relevant Genetic x Environmental Exposures

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-E(56)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative Identification of tumor-specific T cells is critical to immunotherapy development, yet remains a challenging task. In this project we will develop a novel machine learning method to study: 1) which T cells in the tumor microenvironment are reactive to malignant cells; 2) what signature genes can be used to track the cancer- specific T cells. Outcomes from this project are expected to improve the efficacy and precision of cancer immunotherapies.

PI_NAMEs: LI, BO  (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Adaptive Immune System;Adopted;Amino Acid Sequence;Animal Model;anti-cancer;anti-cancer treatment;antigen binding;antigen-specific T cells;Antigens;Autoimmune;Autoimmunity;Autologous;Binding;Biochemical;Biological Assay;Biological Markers;biomarker identification;BRAF gene;cancer biomarkers;cancer cell;Cancer cell line;cancer diagnosis;cancer genomics;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;CD28 gene;Cell Line;Cell Separation;Cellular immunotherapy;Classification;Clinical;clinical application;Clinical Trials;complementarity-determining region 3;Computer software;Computing Methodologies;Cord Blood Hematopoietic stem cells;Data;Data Set;deep learning;design;Development;Diagnosis;Future;gag Gene Products;Genes;genetic signature;genomic data;Goals;Hematopoietic stem cells;HLA-A gene;Human;humanized mouse;IL2RA gene;Immune;Immune response;Immunodeficient Mouse;Immunotherapy;improved;in vivo;Individual;Infiltration;Innate Immune System;learning strategy;Machine Learning;machine learning method;Malignant Neoplasms;Melanoma Cell;Methods;neoantigens;neoplastic cell;novel;Oncogenes;Open Reading Frames;Outcome;Patients;peripheral blood;Post-Translational Protein Processing;predictive marker;Prognosis;receptor;reconstitution;response;Safety;Sampling;side effect;single cell sequencing;single-cell RNA sequencing;software development;Sorting;Source;success;T cell infiltration;T-Cell Receptor;T-Lymphocyte;Testing;therapy development;Tissue-Specific Gene Expression;Tissues;tool;Training;training data;transcriptome;transcriptome sequencing;Treatment Efficacy;tumor;Tumor Antigens;Tumor Expansion;tumor immunology;tumor microenvironment;Tumor stage;unsupervised learning;Validation;Xenograft procedure

PROJECT_TITLE: Antigen-independent prediction and biomarker identification of cancer-specific T cells

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]