ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The proposed administrative supplement will preserve the objectivity and potential clinical implications of the parent R34 grant by supporting the incorporation of biomarkers of unhealthy alcohol use, Ethyl glucuronide (EtG) and Phosphatidylethanol (PEth), reliable for measuring recent and chronic alcohol use, respectively. When the proposal was submitted, there was a reasonable expectation that the costs of these tests would be indirectly subsidized for research purposes, based on NIAAA-funded colleagues’ previous experience, but this is no longer the case. Accordingly, to preserve the potential benefit of the proposal for the overall research community as well as its potential impact on NIH-funded research, we are submitting this noncompeting administrative supplement proposal to fund the unsubsidized cost of EtG and PEth testing.

PI_NAMEs: BRAITHWAITE, RONALD SCOTT (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Administrative Supplement;Alcohol consumption;alcohol misuse;alcohol testing;alcohol use disorder;Alcohols;Biological Markers;Blood;Blood Circulation;cardiovascular risk factor;Caring;Cell membrane;Characteristics;chronic alcohol ingestion;Clinical;Collection;Communities;Compensation;Complement;Consumption;cost;cost effective;Cost Effectiveness Analysis;Data;Detection;Elements;Enrollment;Erythrocytes;Ethanol;Ethnic Origin;Excretory function;expectation;experience;Frequencies;Funding;Glucuronides;Goals;Grant;Health;health disparity;health goals;Heavy Drinking;high risk population;HIV risk;Hour;Individual;Ingestion;Intention;Intervention;Lecithin;Liver;Liver Failure;low socioeconomic status;Measures;medication nonadherence;Methods;Modeling;Monitor;mortality;National Institute on Alcohol Abuse and Alcoholism;outcome disparities;parent grant;Parents;Participant;Pathway interactions;Patient Self-Report;Peer Review;phosphatidylethanol;Population;Predisposition;preference;preservation;Prevention;Preventive care;Process;Race;Reaction;Research;response;screening;sex;sexual risk taking;social;social stigma;System;Testing;Time;Time Study;Travel;United States National Institutes of Health;Urine;Work

PROJECT_TITLE: Can a radical transformation of preventive care reduce mortality by 20% in low SES populations?  Preparatory work focusing on AUD/heavy alcohol use, HIV risk, and cardiovascular risk


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Disability Research;Dissemination and Implementation Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The “virtual front door”–websites and digital information–is often the first interaction point that patients have with healthcare systems. However, people who are blind or have low vision face barriers using this front door at many academic medical centers, blocking their access to life-saving specialty care. We propose to change academic medical centers to reduce the impacts of structural ableism that block access to healthcare settings, by building dashboards that report on the accessibility of these virtual front doors and creating and testing tools to improve that accessibility.

PI_NAMEs: IWASHYNA, THEODORE J (contact);SWENOR, BONNIELIN

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: ableism;Academic Medical Centers;academic review;Administrator;Adoption;Age;American;Appointment;Appointments and Schedules;Area;barrier to care;blind;Blindness;Caring;Clinic;Communities;Coronavirus;dashboard;Data;Data Collection;data dashboard;design;Diabetes Mellitus;digital;disability;Disabled Persons;Education;Effectiveness;Epidemiology;Equity;Ethnic Origin;Evaluation;experience;Eye;Face;Foundations;Funding;Gender;Geography;Guidelines;Health;health care availability;health care delivery;health care settings;health data;health equity;Health Policy;Health Services Research;Healthcare;Healthcare Systems;Hospitals;implementation science;improved;Information Management;Institution;interest;Intervention;Justice;Legal;Life;Lived experience;Lung;medical specialties;meetings;member;Methodology;National Eye Institute;Nephrology;Neurology;Participant;Patient Care Management;Patients;person centered;Persons;Policies;pressure;Private Sector;Procedures;Process;programs;prototype;Public Health;racial diversity;recruit;Reduce health disparities;Reporting;Reproducibility;Research;Sampling;service delivery;structural ableism;System;System for Public Use;Teaching Hospitals;Techniques;Technology;Testing;tool;uptake;virtual;vision science;Visual impairment;web site

PROJECT_TITLE: Removing Barriers to Healthcare for People with Vision Impairment (the RAMP Program)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-D (50)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Hypertension

ORG_CITY: JACKSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative More than fifty percent of adults and children in the United States suffer from have high arterial blood pressure (hypertension); if left untreated, hypertension leads to cardiovascular and kidney disease and stroke. The purpose of this application is to request travel and caregiver funds to support trainees and junior investigators who wish to attend and participate in the Hypertension Scientific Sessions 2024 to be held in Chicago on September 5–8, 2024. By supporting the travel, education, and development of these promising early-career scientists to this preeminent meeting, we hope to expand and diversify the current workforce, ultimately increasing innovation in hypertension research.

PI_NAMEs: RECKELHOFF, JANE F (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Adult;Advocacy;American Heart Association;Applied Skills;Area;authority;Award;Blood Pressure;Cardiovascular Diseases;Cardiovascular system;career;Caregivers;Case Study;Cessation of life;Chicago;Child;Clinical;clinical practice;Clinical Sciences;Clinical Skills;Collaborations;Data;design;Development;Discipline;Education;Environment;Event;Expenditure;Faculty;Feedback;Fostering;Functional disorder;Funding;Genetic;Goals;graduate student;Grant;Heart Diseases;Hypertension;improved;innovation;Institution;interest;International;Journals;Kidney;Kidney Diseases;Knowledge;Learning;lectures;Left;Manuscripts;marginalized community;meetings;Mentors;Mission;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Nature;next generation;Obesity;Oral;oral communication;Patient-Focused Outcomes;peer;Peer Review;Personal Communication;Physiology;Postdoctoral Fellow;posters;pressure;primary care provider;Publications;Publishing;renal damage;Request for Proposals;Research;Research Personnel;Risk Factors;Scientist;Seasons;Senior Scientist;Stroke;Students;symposium;Time;Travel;trend;United States;Woman;Work

PROJECT_TITLE: AHA Hypertension Scientific Sessions

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M4)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Pneumocystis is the most common cause of fungal pneumonia in children. To date there has not been an ability to culture this organism to understand how the fungus attaches to host cells what antibiotics can kill it. We have developed a lung slice model and we will validate this model under this proposal.

PI_NAMEs: KOLLS, JAY K (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Air;Alveolar Macrophages;antagonist;anti-fungal agents;anti-microbial drug;Antibiotic susceptibility;Antibiotics;Antimicrobial Resistance;atovaquone;beta-Glucans;Biological Assay;CD209 gene;Cells;Child;Complication;Culture Media;Data;Diagnostic;Drug Interactions;folic acid metabolism;fungal pneumonia;fungicide;fungus;Gelatin;Genes;Genomics;Glucans;Goals;Growth;HIV Infections;HIV Seronegativity;Hour;Immunocompromised Host;In Vitro;in vivo;in vivo Model;Individual;infancy;Infant;Infection;Life Cycle Stages;Liquid substance;Lung;Macrophage;Mannans;mannose receptor;Mediating;melting;metabolomics;Microbial Biofilms;Modeling;monocyte;Mus;Organism;Pathogenesis;Pentamidine;Pneumocystis;Pneumocystis carinii Pneumonia;Process;Proteomics;receptor;Research;Role;Sepharose;Slice;Structure of parenchyma of lung;Testing;tool;transcriptome sequencing;transcriptomics;Trimethoprim-Sulfamethoxazole

PROJECT_TITLE: In vitro PCLS models of Pneumocystis

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rehabilitation

ORG_CITY: PULLMAN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative The proposed research is relevant to public health because it is the first study to systematically assess the prevalence of medical ableism and its consequences for patient care and health within a large and inclusive national sample of U.S. adults with disabilities. The long-term goal of our research is to develop a nuanced and comprehensive understanding of medical ableism that will ultimately allow us to develop targeted interventions to mitigate its effects on the health of people with disabilities. The project will model best practices in disability inclusion and representation, and further the National Center on Medical Rehabilitation Research’s mission to foster the development of scientific knowledge needed to enhance the health, productivity, independence, and quality of life of people with disabilities.

PI_NAMEs: KENNEDY, JAE  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: ableism;Ableist;Adopted;Adult;Adverse effects;Adverse event;Advocate;Affect;Attitude;Belief;Caring;Data;Data Sources;Development;Dimensions;Disabilities experience;disability;Disability Evaluation;Disability outcome;disabled;Disabled Persons;Disparity;Educational Curriculum;Environment;Ethnic Origin;evidence base;experience;field survey;Fostering;Frequencies;Gender;Goals;Health;Health behavior;health care settings;health disparity;health inequalities;Health Personnel;Healthcare;Intervention;Knowledge;Learning Disabilities;loss of function;Measures;Medical;Medical Education;Mental Health;Mission;Modeling;Nature;Neurological disability;Observational Study;Patient Care;Patients;Persons;physical conditioning;physically handicapped;Prevalence;Productivity;Provider;psychiatric disability;Public Health;public health research;Quality of life;Race;rehabilitation research;Rehabilitation therapy;Reporting;Research;Research Personnel;Research Project Grants;response;risk prediction;Sample Size;Sampling;Sensory disabilities;Severities;Sex Orientation;Socioeconomic Status;Surveys;treatment planning;user-friendly

PROJECT_TITLE: Disability Perspectives on the Adverse Health Effects of Medical Ableism


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: WALTHAM

ORG_DEPT: MISCELLANEOUS

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE There is an urgent need to address the deleterious effects of ableist practices and policies on the pregnancy-related experiences and outcomes of women with disabilities. While research shows that women with disabilities are as likely to choose pregnancy and parenthood as their nondisabled counterparts, they have a significantly higher risk for adverse maternal and child health outcomes driven by barriers to appropriate care, stigma, and inadequate provider training. This study will develop an online continuing education program for obstetricians with the goal of increasing the timely provision of evidence- based, inclusive perinatal care to women with disabilities.

PI_NAMEs: IEZZONI, LISA I.;MITRA, MONIKA  (contact)

PROJECT_TERMS: ableism;Ableist;Address;Affect;Age;American College of Obstetricians and Gynecologists;Attitude;Belief;Birth;Caring;Child;Clinical;Collaborations;Communication;Communities;Continuing Education;continuing medical education;Course Content;court;Data;design;disability;Disabled Persons;Discipline of obstetrics;E-learning;Education;Educational Intervention;effectiveness testing;Enrollment;Equipment;Ethnic Origin;Eugenics;evidence base;experience;Feedback;Focus Groups;Funding Agency;Gender;Goals;Guidelines;Health;health care service utilization;Health Personnel;Health system;high risk;Hour;improved;Income;informant;innovation;Institutionalization;Intellectual functioning disability;Intervention;Interview;Knowledge;Knowledge acquisition;Licensure;Maternal and Child Health;Measures;motherhood;Movement;Outcome;Participant;Patients;peer;Perinatal Care;Persons;physically handicapped;Physicians;pilot test;Policies;Population Heterogeneity;postpartum care;Postpartum Period;Pregnancy;Pregnancy Rate;pregnant;Pregnant Women;Professional Organizations;programs;Provider;Quality of Care;Race;Randomized;Randomized, Controlled Trials;Recommendation;Reduce health disparities;Reporting;reproductive;Reproductive Health;Research;Research Personnel;response;Review Literature;satisfaction;Sensory disabilities;service delivery;Services;Sex Orientation;social norm;social stigma;Specific qualifier value;Stigmatization;structural ableism;Structure;Surveys;Testing;Training;usability;Virginia;Woman;women of color;women with disabilities;women's outcomes

PROJECT_TITLE: A Continuing Education Intervention to Address Ableism Among Obstetric Clinicians Providing Perinatal Care


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Acute myeloid leukemia (AML) is the most lethal hematological malignancy, and alternatives to chemotherapy such as differentiation therapy are greatly needed. We recently found that the H3K9 histone acetyltransferase KAT6A cooperates with the H3K9ac reader protein ENL to promote stemness and proliferation in AML. Here, we aim to determine the molecular mechanisms by which KAT6A and ENL cooperate to drive leukemogenic gene expression programs, and to identify the genetic subtypes of AML that are most sensitive to KAT6A inhibition.

PI_NAMEs: BLANCO, MARIO ANDRES (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Ablation;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Binding;Biochemical;Biological Assay;burden of illness;Cell Cycle;Cell Differentiation process;Cell Proliferation;Cell Survival;Cells;chemotherapy;Chimeric Proteins;ChIP-seq;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complex;CRISPR screen;Data;design;Differentiation Therapy;Disease;Disease Progression;Disease remission;DNMT3a;ENL Protein;Epigenetic Process;epigenome;epigenomics;FLT3 gene;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Hematologic Neoplasms;Hematopoiesis;histone acetyltransferase;histone-binding proteins;Human;Impairment;In Vitro;in vivo;Individual;inhibitor;KDM1A gene;Knock-out;Mass Spectrum Analysis;Methodology;Methods;Methylcellulose;MLL-AF9;MLL-rearranged leukemia;Modeling;Molecular;mouse model;Mus;mutant;Myelogenous;novel;Oncogenes;Patients;Pharmaceutical Preparations;Play;programs;Progranulocytes;Proliferating;promoter;protein complex;Reader;recruit;response;Role;Sampling;Scheme;self-renewal;small molecule;stemness;success;synergism;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Toxic effect;transcription factor;transcriptome;transcriptome sequencing;transplant model;treatment effect;Work;Xenograft Model

PROJECT_TITLE: Investigating the role of KAT6A in MLL-rearranged acute myeloid leukemia


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project Narrative As a result of ableism, people with disabilities (PWD) experience diagnostic overshadowing—attributing symptoms to disability rather than a potentially new or comorbid condition. In our End Diagnostic Overshadowing program our goal is to identify and create understanding of mechanisms underlying diagnostic overshadowing and then develop means to reduce it, specifically targeted education programs and decision supports for healthcare professionals. If successful, we will have developed a system for identifying and creating understanding of mechanisms underlying diagnostic overshadowing and will have created specific means to mitigate and reduce its effects.

PI_NAMEs: AILEY, SARAH HERRINK (contact)

PROJECT_TERMS: 3 year old;ableism;Address;Adult;Affect;aged;Blindness;Blood Vessels;Caring;Cause of Death;Characteristics;Child;Clinical;Code;Community Integration;comorbidity;cost;County;Data;deafness;Decision Making;Developmental Disabilities;Developmental Disabilities Nursing;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Errors;Disabilities experience;disability;Disability outcome;Disabled Persons;Discrimination;Education;Electronic Health Record;Environment;Ethnic Origin;Ethnic Population;Evaluation;Event;experience;Facility Accesses;follow-up;formative assessment;Gender;Goals;Health;health disparity;Health Professional;Health system;Healthcare;hearing impairment;high risk;implicit bias;improved;Individual;Infection;innovation;Inpatients;Insurance;Intellectual functioning disability;intersectionality;Interview;Joints;Knowledge;Malignant Neoplasms;marginalization;marginalized population;Medical center;member;Mental Health;Methods;Minnesota;Mobility decline;Modeling;novel;Oral;Outcome;Outpatients;Pain;Patient Care;Patients;Persons;Physicians;Population;Procedures;Process;Production;programs;provider communication;quality assurance;Race;racial population;Recommendation;Reporting;Research;Risk;Sentinel;Symptoms;System;Technology;Tracer;Trauma;Universities;Update;Visual impairment;Work

PROJECT_TITLE: End Diagnostic Overshadowing: Addressing Ableism in the Healthcare Context


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE Impaired bile acid homeostasis contributes to the pathogenesis of cholestatic liver disease and liver injury as well as many metabolic diseases including obesity and type-2 diabetes. The SEL1L-HRD1 protein complex represents the most conserved branch of mammalian endoplasmic reticulum (ER)-associated degradation (ERAD) machinery, responsible for the recruitment and retrotranslocation of ER proteins for cytosolic proteasomal degradation. This study will test an exciting hypothesis that hepatic SEL1L-HRD1 ERAD protein complex plays a critical role in bile acids homeostasis by regulating bile acid biosynthesis.

PI_NAMEs: FANG, DEYU ;QI, LING  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: 26S proteasome;Amino Acids;autosome;Back;Bile Acid Biosynthesis Pathway;bile acid metabolism;Bile Acids;Binding Proteins;C-terminal;cell type;Cholestasis;Cholesterol;Cholesterol Homeostasis;chronic liver injury;cofactor;complement pathway;Complex;CYP7A1 gene;Cytoplasmic Tail;Data;Defect;Disease;early childhood;Endoplasmic Reticulum;Event;Exhibits;Feedback;FGF21 gene;fibroblast growth factor 21;Functional disorder;Funding;Gene Expression;Genetic Transcription;Health;Hepatic;Hepatocyte;Homeostasis;Human;Hydroxysteroid Dehydrogenases;Impairment;insight;Integral Membrane Protein;intrahepatic;Knock-out;Knockout Mice;Laboratories;Left;Link;Lipids;Liver;Liver Cirrhosis;Liver diseases;Liver Failure;liver injury;liver transplantation;Maintenance;Malabsorption Syndromes;Mediating;Metabolic Diseases;misfolded protein;Missense Mutation;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutation;Neonatal;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obesity;Obstructive Jaundice;Pathogenesis;Pathologic;Pathway interactions;Patients;Physiological;Play;Process;protein complex;protein degradation;protein function;Proteins;Qi;Quality Control;receptor;recruit;Regulation;Reporting;response;Role;Signal Pathway;Testing;Therapeutic;transcription factor;treatment strategy;ubiquitin-protein ligase;Ubiquitination;Vitamins

PROJECT_TITLE: Novel role of hepatic SEL1L-HRD1 ERAD in bile acid metabolism

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Diabetes;Kidney Disease;Nutrition;Obesity;Pediatric;Polycystic Kidney Disease

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The proposed clinical trial aims to assess if a glucagon-like peptide 1 receptor agonist, a medication approved for weight management that also improves the body's response to glucose and insulin, can slow kidney growth in adults with autosomal dominant polycystic kidney disease who are overweight or obese. The study will also evaluate changes in abdominal fat and kidney metabolism using cutting-edge images techniques. Blood and urine samples will provide further insight into biological changes that may be linked to the benefits of the intervention, while ensuring careful monitoring of safety and tolerability.

PI_NAMEs: BJORNSTAD, PETTER ;NOWAK, KRISTEN LYNN (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: abdominal fat;Acceleration;Acetates;Adherence;adipokines;adiponectin;Adipose tissue;Adult;Adverse event;Affect;Agonist;Alternative Therapies;Attenuated;Autosomal Dominant Polycystic Kidney;Biological;Biological Markers;Blood;Body mass index;Body Weight;Body Weight decreased;C-reactive protein;Caloric Restriction;Cell Respiration;Chronic Kidney Failure;Clinical;Clinical Trials;cost;Cystic kidney;Data;Deceleration;Diabetes Mellitus;Diet;Disease Management;Disease Progression;Dose;Double-Blind Method;efficacy evaluation;Endocrinology;Ensure;Event;Exhibits;experience;Face;FDA approved;Funding;General Population;GLP-I receptor;Glucose;Glucose Clamp;Growth;Height;Hereditary Disease;Hyperinsulinism;Imaging Techniques;Impairment;improved;Individual;Inflammation;inflammatory marker;insight;Insulin;Insulin Resistance;insulin sensitivity;Interleukin-6;Intervention;Isoprostanes;Kidney;Kidney Diseases;Kidney Failure;kidney metabolism;kidney preservation;Label;Leptin;lifestyle intervention;Link;lipid metabolism;Magnetic Resonance Imaging;Measures;Metabolic;Monitor;Nephrology;novel;novel therapeutics;Obesity;obesity treatment;Outcome;Overweight;Oxidative Stress;Participant;Patients;Perfusion;Pharmaceutical Preparations;pharmacologic;Phase;Phase II Clinical Trials;Pilot Projects;Placebo Control;Placebos;Positron-Emission Tomography;premature;Prevalence;primary outcome;Property;protective effect;Questionnaires;Randomized;Renal function;response;Safety;safety assessment;Sampling;secondary outcome;side effect;subcutaneous;tolvaptan;urinary;Urine;Visceral;Weight;Weight maintenance regimen

PROJECT_TITLE: Advancing ADPKD Treatment with GLP-1RA: A Study of Glucagon-Like Peptide-1 Receptor Agonists' Efficacy, Safety, and Mechanism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-L (91)]


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_STATE: NY

PHR: NARRATIVE To correct long-standing racial/ethnic health inequities, research is needed to identify policies that address the structural conditions contributing to persistently high rates of firearm violence. Local alcohol control and economic support policies are two promising sets of such policies. This study will rigorously evaluate their effectiveness in reducing firearm assault injuries and generate actionable evidence on which policies local governments should enact or avoid to reduce firearm violence and promote health equity.

PI_NAMEs: MATTHAY, ELLICOTT COLSON (contact)

PROJECT_TITLE: RFA-CE-24-030,  Social policies to prevent firearm assault

STUDY_SECTION_NAME: Special Emphasis Panel[ZCE1 TQD (30)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Complementary and Integrative Health;Dietary Supplements;Estrogen;Natural Products;Nutrition;Prevention

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death in the US. Despite a worse profile of lifetime exposure to many ASCVD risk factors in Japan, ASCVD mortality is less than half of that in the US. Understanding the mechanisms of low ASCVD mortality in Japan could lead to novel preventive and therapeutic strategies for reducing the burden of ASCVD in the US.

PI_NAMEs: BENOS, PANAGIOTIS V;SEKIKAWA, AKIRA  (contact)

PROGRAM_OFFICER_NAME: KIRBY, RUTH

PROJECT_TERMS: Affect;Age;Atherosclerosis;Biological;Blood;Blood specimen;cardioprotection;cardiovascular disorder prevention;cardiovascular disorder risk;Case/Control Studies;Cause of Death;Characteristics;Cholesterol;Clinical;cohort;Cohort Studies;Collection;Complex;complex data;Computer Models;Consumption;daidzein;Data;Data Set;Dependence;Developed Countries;Diet;dietary;Dietary intake;Disease;Environmental Exposure;equol;Exhibits;Exposure to;flexibility;Foundations;Future;Genetic Predisposition to Disease;Goals;gut bacteria;Individual;innovation;insight;Intake;Intestines;Japan;Japanese;Knowledge;Link;machine learning method;marine;Medical;metabolomics;Methods;Migrant;model building;Modeling;mortality;neglect;Nested Case-Control Study;novel;Observational Study;Odds Ratio;Omega-3 Fatty Acids;Prevention;Preventive;Production;Property;Prospective, cohort study;protective effect;randomized, clinical trials;Reporting;Risk;Risk Factors;Risk Reduction;sex;soy protein isolate;Supplementation;Testing;Therapeutic;tool;United States National Institutes of Health;Validation;Variant;Vascular Cognitive Impairment

PROJECT_TITLE: Integrative Model of Metabolomics, Equol and Atherosclerotic cardiovascular disease (IMMEA)

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Relevance: PennCSER will provide cutting edge expertise in the area of epigenetics of reproduction that will rapidly translate into treatment of human infertility, bring further expertise to the NCTRI program, train the next generation of reproductive biologists, including physician scientists and basic research scientists, and educate the lay public and high school students about the reproductive sciences.

PI_NAMEs: BARTOLOMEI, MARISA S. (contact);COUTIFARIS, CHRISTOS

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Academy;Adult;advanced maternal age;Area;Assisted Reproductive Technology;Basic Science;Behavior;Biology;Birth;career;Center for Translational Science Activities;Childhood;Clinical;Conceptus;Coupled;Couples;Development;Discipline of obstetrics;DNA Methylation;Embryo;Epigenetic Process;epigenome;experience;Faculty;Female;Fertility;Floor;Gene Expression;Gene Expression Regulation;Germ Cells;Goals;Gonadal Steroid Hormones;Gynecology;Hand functions;Health;High School Student;Human;human model;In Vitro;induced pluripotent stem cell;Infertility;infertility treatment;innovation;Intervention;Invaded;laboratory equipment;laboratory experience;Lead;lectures;male;male fertility;Male Infertility;Marriage;Medical;medical schools;Meiosis;member;Metabolic;mosaic;mouse development;mouse model;next generation;novel;Oocytes;organ on a chip;Outcome;outreach program;Oxygen;Pennsylvania;perinatal outcomes;Philadelphia;Physicians;Physiological;Placenta;placental morphology;Pregnancy;programs;Proteins;Reproduction;reproductive;Reproductive Biology;Reproductive Sciences;Research;Research Personnel;Research Project Grants;Resources;Retrotransposon;Schools;Scientist;Sex Chromosomes;sexual dimorphism;Spermiogenesis;student training;success;System;technology intervention;Tissues;Training;transcriptome;Translating;trophoblast;Umbilical Cord Blood;Universities;Women's Health

PROJECT_TITLE: Penn Center for Study of Epigenetics in Reproduction

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-Z (55)]


PI_NAMEs: SHUDA, JAMIE  (contact)

PROJECT_TERMS: 2019-nCoV;Academy;Area;Attention;Bioethics;Biological Sciences;Biology;career;Cell Culture Techniques;Cities;cohort;college;combat;Country;COVID-19 pandemic;Decision Making;Dedications;design;Development;Disabled Persons;Disparity;Disparity population;Distance Learning;DNA Structure;Education;Education and Outreach;Educational Curriculum;Educational process of instructing;Educational workshop;empowerment;Epigenetic Process;Ethics;experience;Feedback;Future;Genetic;Goals;Grant;hands on research;high school;High School Faculty;High School Student;Immunology;interest;Internships;journal article;K-12 science education;K-12 student;Laboratories;Learning;Learning Skill;Life;Location;Mathematics;Medicine;member;men;Menstrual cycle;Methods;outreach;outreach program;Persons;Philadelphia;Physiology;posters;Process;programs;Reproduction;Reproductive Health;Reproductive Medicine;Reproductive Sciences;Research;Research Personnel;school closure;School-Age Population;Science;science education;Science, Technology, Engineering and Mathematics;Scientist;Series;Side;skills;Students;success;summer internship;teacher;Teacher Professional Development;Time;Training;Universities;virology;Woman;Work;young man;young woman;Youth;Zebrafish

PROJECT_TITLE: Core B: Education/Outreach Core


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Infertility;Maternal Health;Pediatric;Pregnancy;Prevention;Women's Health Research

PI_NAMEs: SENAPATI, SUNEETA  (contact)

PROJECT_TERMS: Abnormal Cell;Abnormal placentation;Adult;Adverse event;adverse outcome;adverse pregnancy outcome;Affect;Age;Aneuploidy;Assisted Reproductive Technology;at-risk pregnancies;Biopsy;Birth;Cardiometabolic Disease;cardiometabolism;cell free fetal DNA;Child;Childhood;Clinical;clinical care;clinical phenotype;cohort;Conceptions;Cryopreservation;Data;Development;Diagnostic;diagnostic tool;Disease;DNA Methylation;early pregnancy;egg;Embryo;embryo cryopreservation;Embryo Research;Embryo Transfer;Emerging Technologies;Endocrine;Enrollment;Epigenetic age;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Exhibits;Female;Fertility;fertility preservation;Fertilization in Vitro;fetal;Future;Gene Expression;genome-wide;Gestational Age;Goals;Health;high risk;Human;Hypertension;improved;in vitro Model;Individual;innovation;Intervention;Investigation;Laboratories;Lead;life span;Link;Longterm Follow-up;Low Birth Weight Infant;Maternal Age;maternal serum;Metabolic;Methods;Methylation;mouse model;Multiple Pregnancy;Mus;Neonatal;new technology;offspring;older women;Oocytes;Outcome;Ovarian;Patients;Perinatal;perinatal outcomes;Placenta;Placentation;Pre-Eclampsia;Predisposition;Pregnancy;Pregnancy Rate;Preimplantation Diagnosis;prevent;Procedures;recruit;Reproduction;reproductive function;Risk;Role;Safety;sex;Stress;success;Superovulation;Technology;technology intervention;Tissues;Umbilical Cord Blood;Work;young woman

PROJECT_TITLE: Project 1: Epigenetic Regulation of Placental and Fetal Gene Expression in Human Pregnancy


PI_NAMEs: BARTOLOMEI, MARISA S. (contact)

PROJECT_TERMS: Abnormal placentation;Accounting;Address;Adverse effects;adverse outcome;Age;Angelman Syndrome;Assisted Reproductive Technology;Atmosphere;Beckwith-Wiedemann Syndrome;Behavioral;Biological Assay;Biological Models;Birth;blastocyst;Child;Chromatin;Chromatin Structure;Conceptus;Congenital Abnormality;Couples;Data;Development;Disease;DNA;DNA Methylation;Effectiveness;egg;Embryo;embryo cryopreservation;embryo culture;Embryo Transfer;Embryonic Development;Environment;Environmental Exposure;Epigenetic Process;Exhibits;experience;Experimental Designs;experimental study;falls;Fertility;Fertilization in Vitro;fetal;Fetal Weight;Fetus;Funding;Gene Expression Regulation;Genes;genome-wide;Germ Cells;Goals;Growth;Health;Heart Diseases;histone demethylase;Histones;Hormonal;Human;human data;Iatrogenesis;imprint;improved;in vivo;Individual;Infertility;infertility treatment;insight;intercalation;Intervention;Low Birth Weight Infant;Marriage;Maternal Age;Mediating;Metabolic;Metabolic Diseases;Modeling;Modification;Molecular;Morphology;mouse model;Mus;Normal Range;offspring;older women;Oocytes;Outcome;Oxygen;Patients;Pattern;Phenotype;Physiological;Physiology;Placenta;Placenta Diseases;placental morphology;Placentation;postnatal;Pregnancy;Preimplantation Diagnosis;Procedures;Proteins;Repetitive Sequence;Reproduction;Research;Risk;Role;Safety;sexual dimorphism;success;technology intervention;Test Result;Testing;Therapeutic;Validation;Weight;Work

PROJECT_TITLE: Project 2: Epigenetic, Behavioral, and Physiological Outcomes in a Mouse ART Model


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Estrogen;Genetics;Infertility;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

PI_NAMEs: MAINIGI, MONICA AILAWADI (contact)

PROJECT_TERMS: Adrenal Cortex Hormones;adverse outcome;Affect;Androgen Receptor;Animal Model;Assisted Reproductive Technology;Behavior;Birth;blastocyst;Cell Line;Cells;Child;Clinical;Complement;Conceptions;Data;Development;Devices;Diet;directed differentiation;Disease;early pregnancy;Embryo;embryo cryopreservation;embryo culture;Embryo Transfer;Environment;Epigenetic Process;epigenome;Estrogen Receptors;Estrogens;Ethanol;Event;experimental study;Exposure to;Female;fetal;Fetus;Gene Expression;Gestational Age;Gonadal Steroid Hormones;Gonadal structure;Histopathology;Hormonal;Human;human male;human model;Hypoxia;implantation;in utero;in vitro Model;Individual;induced pluripotent stem cell;Infection;innovation;innovative technologies;Intervention;Invaded;Knowledge;Lead;male;Maternal-Fetal Exchange;Modeling;Morbidity - disease rate;mortality;Mothers;Mus;novel;organ on a chip;Outcome;Oxygen;Pathogenesis;Pathway interactions;perinatal complications;perinatal outcomes;Phenotype;Placenta;placental morphology;placental trophoblasts;Placentation;Ploidies;pluripotent stem cell differentiation;Positioning Attribute;Predisposition;Pregnancy;prenatal exposure;Process;Production;Protocols documentation;Recording of previous events;Regulation;Reproduction;Resources;response;Risk;Role;sex;sex as a biological variable;Sex Chromosomes;Sex Differences;sexual dimorphism;Specimen;Superovulation;Syncytiotrophoblast;Technology;technology intervention;Testosterone;Time;transcriptome;transcriptomics;trophoblast;trophoblast stem cell;United States National Institutes of Health;Uterus;Villous

PROJECT_TITLE: Project 3: The role of sex in ART-associated changes in trophoblast behavior and epigenetics


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Human Genome;Infertility;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: WANG, PEIJING JEREMY (contact)

PROJECT_TERMS: Affect;Amino Acids;Area;ATAC-seq;Binding;Binding Proteins;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Clinic;Complex;Consultations;Data;demethylation;Development;Disease;DNA;DNA Methylation;Elements;Endogenous Retroviruses;Epigenetic Process;epigenetic regulation;epigenetic silencing;epigenome;Evolution;Exhibits;exome sequencing;experimental study;Failure;Fertility;Fertilization in Vitro;Funding;Gene Expression;Genes;Genetic;Genetic Diseases;Genetic Transcription;Genome;genome integrity;genome-wide;Genomics;Germ Cells;Germ Lines;Growth;Head;Heterochromatin;Heterogeneity;histone modification;Histones;Histopathology;Human;human male;human model;imprint;Infertility;infertility treatment;insight;Investigation;Knock-out;Link;male fertility;Male Infertility;mammalian genome;Mediating;men;Methylation;Modeling;Molecular;Monoclonal Antibodies;Morphology;Mosaicism;Mus;mutant;Mutant Strains Mice;Mutation;Nonsense Mutation;novel;Nuclear;Other Genetics;Outcome;Paste substance;Pathway interactions;Patients;Phenotype;piRNA;Play;Point Mutation;postnatal;Process;Production;progenitor;programs;Proteins;Proteomics;Reproduction;Research Project Grants;Retrotransposon;Role;Shapes;Short Interspersed Nucleotide Elements;Somatic Cell;Sorting;Specific qualifier value;sperm cell;Spermatids;Spermatocytes;Spermatogenesis;Spermiogenesis;stem cells;Sterility;Testing;Testis;Time;tissue regeneration;Transcriptional Regulation;transcriptome sequencing;Treatment outcome;Untranslated RNA

PROJECT_TITLE: Research Project 4: Epigenetic Regulation of Retrotransposon Silencing and Male Fertility in the Mouse


PROJECT_TERMS: Administrator;Advisory Committees;Assisted Reproductive Technology;Clinical;Collaborations;Committee Members;Complement;design;Development;Effectiveness;Epigenetic Process;Faculty;Fertility;Gametogenesis;Gene Expression Regulation;Goals;Grant;Hand;Human Resources;Hybrids;implantation;Individual;Infertility;interest;meetings;member;outreach;pandemic disease;Pennsylvania;Persons;Philadelphia;Pilot Projects;Placentation;posters;Process;programs;Reporting;Reproduction;Reproductive Biology;Research;Research Personnel;Role;Rotation;Schedule;Site;Time;Training;Travel;United States National Institutes of Health;Universities;virtual;Women's Health

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Dissemination and Implementation Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: PROJECT NARRATIVE The burden of visual disability in the U.S. is substantial and ever-growing; myriad disparities in health and healthcare result in significant inequities, inequities that are not only disproportionately higher for this population but also largely unaddressed. We will use mixed methods to support novel qualitative methods to better understand exactly what is needed with regards to reasonable accommodations and devise an implementation strategy to evaluate and test such services in these populations. Our transdisciplinary and national team will use a patient-centered approach that leverages input from participants with lived experience and disability experts to foster the creation of solutions that promote equity, ultimately benefitting visually impaired persons worldwide.

PI_NAMEs: MORRIS, MEGAN A;RIZZO, JOHN ROSS  (contact)

PROJECT_TERMS: ableism;acceptability and feasibility;Address;Affect;Anxiety;Appointment;Area;Behavior;Blindness;care coordination;Caring;Characteristics;Chronic Disease;Client;Client satisfaction;Clinic;Clinics and Hospitals;Complex;Data;Death Rate;Debility;Diabetes Mellitus;Diagnosis;digital;disability;disabled;Disabled Persons;Disparity;Economic Burden;Ensure;Epidemic;Equitable healthcare;Equity;Evaluation;evidence base;Evidence based intervention;experience;falls;fear of falling;Fostering;Foundations;Fracture;Freedom;Goals;Health;health care availability;health care service;health care service organization;health care settings;health disparity;health equity promotion;health inequalities;Health Personnel;Health Promotion;Health Services Accessibility;Healthcare;Healthcare Systems;Hospitals;Impairment;implementation framework;implementation strategy;Inequity;innovation;Intervention;intervention mapping;Interview;Island;Leadership;lens;Lived experience;long bone;Malignant Neoplasms;Medical;medical services inaccessibility;Mental Depression;Methods;Modeling;navigator intervention;novel;Oncology;Ophthalmology;Outcome;Participant;patient navigation;patient navigator;patient oriented;Patient Recruitments;Patients;Performance;Personal Satisfaction;Persons;Phase;Population;Positioning Attribute;pragmatic study;Premature Mortality;Prevalence;Process;programs;psychosocial;psychosocial outcome;Qualitative Methods;Quality of Care;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research Personnel;Risk;Screening for cancer;secondary outcome;Self-Help Devices;Services;Societies;socioeconomics;stem;structural ableism;structural determinants;Testing;Time;treatment arm;Tumor Burden;Unemployment;Urban Health;Vision;Visit;Visual disability;Visual impairment;Visually Impaired Persons;Waiting Lists

PROJECT_TITLE: Addressing Ableism through Accommodations for Blindness and Low vision to achieve Equity (AAABLE) in Healthcare


ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Adverse Child Experiences are prevalent for youth receiving intensive mental health services (e.g., partial hospitalization programs; inpatient care) and are a cross-cutting risk factor for peer aggression and teen dating violence. Despite aggression serving as a leading cause for referral to IMHS, most youth do not receive aggression-focused care and there are no trauma-informed aggression interventions designed for youth in IMHS. This study aims to develop and evaluate a group-based trauma-informed intervention to reduce peer aggression, prevent teen dating violence, and improve mental health outcomes in preteens (i.e., 11- to 13-year-olds) receiving IMHS.

PI_NAMEs: TAMPKE, ELIZABETH CLAIRE (contact)

PROJECT_TITLE: Cross-Cutting Trauma-Informed Peer Aggression and Dating Violence Prevention for Preteens Receiving Intensive Mental Health Services

STUDY_SECTION_NAME: Special Emphasis Panel[ZCE1 TQD (04)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: White Plains

ORG_NAME: OLIGOMERIX, INC

PHR: PROJECT NARRATIVE There is a critical unmet need for a disease-modifying small molecule drug for Alzheimer’s disease (AD); of the ten leading causes of death in the United States, only AD cannot be prevented or cured and is increasing in incidence. This program is highly important because it is progressing to fill this need with a disease-modifying drug that, if successful, will have a tremendous impact on the more than 6.7 million Americans who currently have AD (projected to be 13.8 million by 2060) and their caregivers, and will also help reduce the current cost of $345 billion (projected to be $1.1 trillion by 2050) to our nation (Alzheimer's Association 2023 Alzheimer's Disease Facts and Figures). This Supplement to the awarded R01 will cover unanticipated incremental costs related to project delays directly attributable to FDA requests for additional toxicology data on the compound prior to progressing to higher doses in human volunteers as well as staff to support these aims, and it is urgent that this Supplement be supported and initiated as soon as possible as currently available clinical supplies will reach their expiry date prior to the anticipated date of completion of clinical activities supported by this grant and cause delay in the completion of the clinical study.

PI_NAMEs: ERHARDT, WILLIAM A. (contact)

PROGRAM_OFFICER_NAME: CLARKE, AKANNI YAO

PROJECT_TERMS: Abnormal Laboratory Test Result;absorption;Adverse event;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;American;Animals;Award;Biological Assay;bioprinting;Canis familiaris;capsule;Cardiopulmonary;Caregivers;Cause of Death;Clinical;clinical development;Clinical Research;cohort;cost;cost effective;Data;Development;Disease;Dose;Double-Blind Method;drug development;Drug Kinetics;Elderly;Enrollment;Event;exposed human population;first-in-human;Formulation;genotoxicity;Goals;Grant;healthy volunteer;human study;Human Volunteers;In complete remission;In Vitro;in vitro Assay;in vivo evaluation;Incidence;incremental cost;inhibitor;innovation;Investigational Drugs;Lead;manufacture;Metabolism;method development;Mission;monomer;mouse model;Mus;No-Observed-Adverse-Effect Level;novel;Oral;Pharmaceutical Preparations;Pharmacology;Pharmacology Study;Phase;Placebos;preclinical study;Prevalence;prevent;Preventive;Process;programs;Randomized;Rattus;recruit;Research;research and development;Research Design;Safety;safety study;Series;small molecule;small molecule inhibitor;stability testing;tau aggregation;tau Proteins;Tauopathies;Technology;Testing;Therapeutic Intervention;Therapeutic Studies;Toxicology;United States;Validation;volunteer;Work

PROJECT_TITLE: First in Human Study of a Tau Self-Association Small Molecule Inhibitor in Healthy Volunteers


ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

PHR: Program Narrative Approximately 12% of men in the United States are subfertile or infertile. Infertility is a pervasive condition that impacts not only the ability to have biological children, but has broader implications for psychological well- being, relationships, finances (assisted reproduction and adoption can be expensive), overall health and life expectancy. The objective of this NCTRI P50 Center for Reproductive Genetics and Therapy is to Improve knowledge about the genetic basis of infertility to aid in the counseling of infertile couples; justify the development of diagnostic screens; and develop patient-specific treatment options.

PI_NAMEs: ORWIG, KYLE EDWIN (contact)

PROJECT_TERMS: Academy;Acceleration;Address;Adoption;Affect;Age;assisted reproduction;Benefits and Risks;Biological;candidate identification;Cardiovascular Diseases;career;Cells;Child;Chimera organism;Clinic;clinical development;clinical diagnostics;Coculture Techniques;Collaborations;Communication;Communities;community college;comorbidity;cost;Counseling;Couples;Critical Thinking;cytokine;Data;Data Analytics;data exchange;Data Set;Development;Diagnosis;Diagnostic;diagnostic development;diagnostic screening;differentiation in vitro;Disease;disease model;Education;Education and Outreach;embryonic stem cell;engineered stem cells;Epigenetic Process;exome sequencing;experience;experimental study;Family;Female;fetal;Funding;Gametogenesis;gene correction;gene therapy;gene-targeted therapy;Generations;Genes;Genetic;genetic linkage;genetic variant;Genetic Variation;genome editing;genome sequencing;Genomics;Germ Cells;Germ Lines;Health;high school;High School Student;Human;idiopathic infertility;improved;In Vitro;Individual;individualized medicine;Infertility;Insertional Mutagenesis;International;junior high school;Knowledge;laboratory experience;Laboratory Research;Lead;Learning Module;Life Expectancy;Link;male;Male Infertility;Malignant Neoplasms;Medical;Medical Genetics;Meiosis;men;Mentors;Metabolic syndrome;Methods;Mission;Modeling;mouse model;Mus;Mutagenesis;Occupations;Pathogenicity;patient derived induced pluripotent stem cells;Patients;personalized medicine;Phenotype;Program Description;programs;Reproduction;reproductive;Reproductive Biology;Reproductive Health;Reproductive Medicine;Research;Risk;Running;safety and feasibility;safety testing;Science;screening;sertoli cell;Site;Specialized Center;stem cells;Structure of primordial sex cell;Students;Sum;targeted treatment;Technology;Teenagers;Testing;Testis;Time;Translating;Translations;transmission process;underserved community;United States;university student;Validation;Variant;Well in self;whole genome;Youth

PROJECT_TITLE: Genetics of Male Infertility: Accelerating the pace of discovery


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infertility;Pediatric;Prevention;Social Determinants of Health

PI_NAMEs: CAMERON, JUDY L (contact)

PROJECT_TERMS: Academy;Acceleration;Address;Adult;Advisory Committees;Area;behavioral health;Caenorhabditis elegans;Career Choice;Cell division;clinical translation;Collaborations;community college;Community Health;Contraceptive Agents;Critical Thinking;Data;Data Analyses;Data Analytics;Data Set;Discipline of obstetrics;Disease;Doctor of Philosophy;Education;Education and Outreach;Educational process of instructing;egg;Embryo;Employee;empowerment;experience;Faculty Workshop;Fertilization;Future;Gender;Genetic;Genetic study;Goals;graduate student;Grant;Gynecology;Habits;Healthcare;high school;High School Student;Infertility;junior high school;laboratory experience;Laboratory Research;Learning;Life;Link;Low income;male;Male Infertility;medical schools;Meiosis;member;Mentors;Microscope;migration;Mission;Modeling;Neonatal Screening;Neurosciences;Nonprofit Organizations;Occupations;outreach;Postdoctoral Fellow;Preparation;professor;programs;Psychiatry;Reproduction;Reproductive Biology;Reproductive Health;Reproductive Sciences;Research;research study;Running;Ruta;Sea Urchins;Sexually Transmitted Diseases;skills;Specialized Center;sperm cell;Student Selections;Students;Swimming;Teacher Professional Development;Time;Training;Training Programs;Translational Research;underserved community;Universities;university student;virtual;Visualization;web site;Work;Youth


PI_NAMEs: CONRAD, DONALD F. (contact)

PROJECT_TERMS: Acceleration;Adult;American;Andrology;autosome;Biology;Center for Translational Science Activities;Clinic;Clinical;clinical diagnosis;cohort;Communities;Complex;Consensus;Credentialing;Data;Databases;Development;Diagnosis;Diagnostic;disease model;Educational workshop;Enrollment;Environment;Europe;Event;exome sequencing;Family;Fertility;fetal;Foundations;Gene Expression;Gene Frequency;gene therapy;Generations;Genes;Genetic;Genetic Services;genetic variant;Genome;genome sequencing;Genomic medicine;Goals;Guidelines;Human;improved;Infertility;innovation;International;Knowledge;knowledgebase;Link;Male Infertility;Medical Genetics;medical schools;meetings;Methods;model organism;Modeling;Modernization;Mutation;novel strategies;Pathogenicity;Patients;Phenotype;Process;public database;Publishing;Records;recruit;Reporting;repository;Reproduction;Reproductive Medicine;Research;research clinical testing;research study;Resources;Sample Size;Scientist;Services;sex;Societies;Solid;Specialist;Standardization;Structure of primordial sex cell;Tandem Repeat Sequences;Testis;Translational Research;Translations;Untranslated RNA;Update;Validation;Variant;whole genome;Work

PROJECT_TITLE: Project I


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Contraception/Reproduction;Genetics;Human Genome;Infertility;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project II: Narative Despite remarkable advances in high-throughput sequencing and computational genomics, a major problem has been in developing tests to validate the predicted causality genetic variants amongst a sea of other variants in any given person. Whereas mouse modeling of human variants is a gold standard for variant validation, it is expensive and time-consuming, a problem exacerbated by the high false positive rate of in silico predictions. This project will deploy and further develop scalable in vitro gametogenesis platforms that have the promise of enabling functional assessment of large numbers of predicted infertility alleles found in the genomes of infertile patients, thereby enabling more rapid and confident clinical diagnostics and potential gene therapies.

PI_NAMEs: SCHIMENTI, JOHN C (contact)

PROJECT_TERMS: Abbreviations;Acceleration;Address;Affect;Alleles;anti-epileptic agents;Anticonvulsants;Breeding;candidate identification;causal variant;Cell Differentiation process;Cells;Chimera organism;Clinical;clinical diagnostics;clinical sequencing;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Code;combinatorial;Complement;Computer Models;Consumption;Coupled;CRISPR-mediated transcriptional activation;cytokine;Defect;design;Development;Diagnostic;dietary supplements;differentiation in vitro;Down-Regulation;Embryo;Embryonic Development;embryonic stem cell;Enabling Factors;Engineering;Epigenetic Process;Etiology;Evaluation;exome sequencing;experimental study;Female;Funding;Gametogenesis;Gene Expression;Gene Targeting;gene therapy;gene-targeted therapy;Genes;Genetic;genetic variant;Genome;Genomics;Germ Cells;Germ Lines;Goals;HDAC4 gene;High-Throughput Nucleotide Sequencing;Histone Deacetylase Inhibitor;Human;human induced pluripotent stem cells;human model;improved;in silico;In Vitro;in vivo;Individual;Infertility;insight;Maintenance;male;Male Infertility;Meiosis;Methods;Mouse Embryonic Stem Cells;mouse model;Mus;Mutation;NCOR2 gene;Pathogenicity;Patients;Persons;Phenotype;prediction algorithm;pregnant;Rapid screening;Reporter;Reporting;reproductive;RNA Interference;screening;Sea;Sodium Butyrate;Somatic Cell;Sorting;Speed;sperm cell;Structure of primordial sex cell;System;Technology;Testing;Testis;Time;Training;transcription factor;Validation;Valproic Acid;Variant;variant of unknown significance

PROJECT_TITLE: Project II


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Gene Therapy;Genetics;Infertility;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

PROJECT_TERMS: Acceleration;Address;adeno-associated viral vector;Adenoviruses;AKAP9 gene;Anatomy;Androgen Receptor;Archives;assay development;Blood-Testis Barrier;cell type;Cells;Clinic;Counseling;Couples;CRISPR/Cas technology;Defect;Dependovirus;Development;Diagnosis;diagnostic development;diagnostic screening;Disease;Endocrine;Environment;Ethics;Exhibits;experimental study;Family;feasibility testing;Female;female fertility;Fertility;Fibroblasts;Frameshift Mutation;Functional disorder;Funding;Future;Gametogenesis;gene correction;gene editing technology;gene therapy;gene-editing approach;Genes;Genetic;genetic variant;Genome;genome sequencing;Germ;Germ Cells;Germ Lines;Hormonal;Human;human induced pluripotent stem cells;human model;idiopathic infertility;Immunologics;improved;In Vitro;in vitro Assay;in vivo;Individual;individualized medicine;induced pluripotent stem cell;Infertility;Knock-out;Knockout Mice;Knowledge;Legal;Lentivirus;male;Male Infertility;Mediating;Medical;Methods;Morphology;mouse model;Mus;novel;patient derived induced pluripotent stem cells;patient screening;Patients;Phenotype;prime editing;Production;programs;Reagent;receptor expression;recruit;reproductive;Risk;safety and feasibility;Sampling;sertoli cell;Sickle Cell Anemia;Skin;Somatic Cell;sperm cell;Spermatogenesis;spermatogenic epithelium structure;stem cells;stemness;Structure of primordial sex cell;Testing;Testis;Toxic effect;translation to humans;transmission process;Transplantation;United States;Validation;Variant;vector;whole genome;women's treatment;Work

PROJECT_TITLE: Project III


PROJECT_TERMS: Acceleration;Address;Administrator;Advisory Committees;Agreement;Animals;Budgets;Collaborations;Communication;Communities;cost effectiveness;Data;data integration;data sharing;data submission;Deposition;Development;diagnostic screening;Discipline of obstetrics;Disputes;Doctor of Philosophy;Education and Outreach;Ensure;Equipment and supply inventories;Expenditure;experimental study;Faculty;Feedback;Fertility;Focus Groups;Fostering;Future;gene-targeted therapy;Genes;Genetic;genetic variant;Germ;Grant;Group Meetings;Gynecology;Human;human disease;human model;Human Resources;Individual;Infertility;Institution;Journals;Knowledge;Learning Module;male;Male Infertility;Medical;medical schools;meetings;member;men;Mentorship;Monitor;mouse model;multidisciplinary;Natural regeneration;operation;outreach;Patient Recruitments;Pennsylvania;Phase;Pilot Projects;Positioning Attribute;programs;Progress Reports;Protocols documentation;recruit;repository;reproductive;Reproductive Biology;Reproductive Sciences;Research;Research Institute;Research Personnel;Resource Sharing;Resources;Review Literature;Rotation;Sampling;Schedule;Scientist;Site;Specialized Center;stem cells;Sum;symposium;Time;Training;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Admin-Core


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: KANSAS CITY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

ORG_STATE: MO

PHR: Project Narrative The proposal request funds to purchase an advanced, environmental-friendly, high performing and high- throughput animal cage and rack washer system and a cloud-based environmental monitoring system for UMKC’s Laboratory Animal Research Core facility. These state of the art systems are required to perform the most rigorous and quantitatively accurate experiments and is needed by NIH-funded scientists, who conduct research on diseases that affect significant and increasing portions of the U.S. population including minorities affected by disparities in health care delivery. Access to these systems will increase the impact of innovative research conducted by researchers by accelerating research progress and enhancing the quality and breadth of research results, determining causes, mechanisms of action and subsequently contributing to discovering potential treatment strategies and improving health care in major medical fields.

PI_NAMEs: KOULEN, PETER  (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: Acceleration;Address;Affect;Aging;animal care;Animal Experimentation;animal facility;animal resource;Animals;Automation;Avidity;Biological;Biomedical Research;bone repair;Caring;Child;Cities;cloud based;cloud storage;Communication;Communities;Computers;Core Facility;cost;Data;design;Detection;Discipline of Nursing;Disease;energy efficiency;Engineering;Environmental Monitoring;Environmental Risk Factor;Equipment;equipment acquisition;experimental study;Extramural Activities;Foundations;Friends;Funding;Future;germ free condition;Goals;Health;health care delivery;health care disparity;Health Sciences;Healthcare;Hospitals;human disease;IACUC;improved;Inflammation;innovation;Institution;Kansas;Laboratory Animals;laboratory experience;Malignant Neoplasms;Measurement;Medical;Medicine;meetings;Metabolic Diseases;Minority;Missouri;Modeling;Modernization;Monitor;muscle physiology;Nonprofit Organizations;novel;operation;Osteogenesis;Pharmaceutical Preparations;Pharmacy facility;Play;Population;pre-clinical;Privatization;Procedures;Process;Productivity;programs;Protocols documentation;Reporting;Reproducibility;Request for Proposals;Research;Research Personnel;Research Project Grants;Research Support;Resources;Rodent;Role;School Dentistry;Schools;Science;Scientist;Services;Skeletal Muscle;Smooth Muscle;square foot;System;Technology;Therapeutic;Time;Training;treatment strategy;United States National Institutes of Health;Universities;uptake;Vendor;Vertebrates;Vision;web platform

PROJECT_TITLE: Modern Equipment for UMKC’s Shared-use Laboratory Animal Research Core Facility to Advance Biomedical Research-Related Operations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (91)]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Metabolically active fat rich in mitochondria (called “brown” or “beige”) maintains insulin sensitivity in healthy individuals, an ability that diminishes with obesity and advancing age in association with a process called fat fibrosis that is closely linked to insulin resistance and type 2 diabetes. Despite HIV medications that have sharply curbed the prevalence of AIDS, the growing population of people living with HIV (PLWH) have concerningly high rates of insulin resistance and diabetes and recent work, including from our group, shows that PLWH also have profound fat fibrosis. We have developed highly innovative tools to monitor brown/beige fat cells in both PLWH and a mouse model of HIV, and propose to use these tools to determine the extent to which a specific subset of fat cells marked by the protein CD81 dictate the propensity of PLWH to develop both fat fibrosis and insulin resistance, providing insight into to new interventional opportunities.

PI_NAMEs: HUNT, PETER W;KOLIWAD, SUNEIL KRISHNA (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Adipocytes;Adipose tissue;Adrenergic Agonists;Aftercare;Aging;antiretroviral therapy;Attention;Biogenesis;Blood Banks;blood glucose regulation;Branched-Chain Amino Acids;Brown Fat;Cardiometabolic Disease;Catabolism;CD81 gene;Chronic;Clinical;co-infection;cohort;Coupled;Cytomegalovirus;Data;data integration;Dedications;Development;Diabetes Mellitus;diabetes risk;Diet;Disease;Elderly;Equilibrium;Fatty acid glycerol esters;Fibrosis;fluorodeoxyglucose;General Population;Genetic;Goals;Health;healthspan;HIV;Human;Impairment;improved;indexing;Individual;innovation;insight;Insulin Resistance;insulin sensitivity;Intervention;lifestyle factors;Link;Measures;Metabolic;metabolic phenotype;Mitochondria;Monitor;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;obese person;Obesity;Persons;PET/CT scan;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;Positron-Emission Tomography;precision medicine;precursor cell;Predisposition;preservation;Prevalence;Process;Proteins;Resources;Risk Factors;Role;specific biomarkers;subcutaneous;Testing;Thermogenesis;Time;tool;trait;Transgenic Mice;Viral;Vulnerable Populations;Work

PROJECT_TITLE: Assessing the Interrelationship Between Adipose Tissue Thermogenesis and Fibrosis in the Metabolic Health of People Living with HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-9 (M2)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Lymphatic Research;Skin Cancer

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Treatment of malignant melanoma has been revolutionized with the introduction of immune checkpoint inhibitors (ICI); however, response to these therapies is not universal. ICI rely on recruitment of T cells into the tumor microenvironment (TME) to perpetuate an anti-tumor immune response. The role of the innate immune system in recruitment of T cells into the TME and how this changes during tumor progression is largely unknown.

PI_NAMEs: O'CONNOR, MARGARET  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;adaptive immunity;Adult;Affect;anti-tumor immune response;Basic Science;Biological Assay;Blood;Cancer Etiology;cancer therapy;career;CD3 Antigens;CD8-Positive T-Lymphocytes;Cell Culture Techniques;Cell Physiology;Cells;Cessation of life;checkpoint therapy;chemokine;Clinical;Clinical Data;Combination immunotherapy;Combined Modality Therapy;cytokine;Cytotoxic T-Lymphocytes;Development;Diagnosis;digital;Disease Progression;draining lymph node;Effectiveness;effectiveness evaluation;Enzyme-Linked Immunosorbent Assay;Evaluation;Failure;first responder;Foundations;Frequencies;Goals;Heterogeneity;Human;IL17 gene;IL7R gene;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;immune function;Immune response;Immunologic Surveillance;improved;Inflammation;inhibitor;innate immune pathways;Innate Immune System;Location;lymph nodes;Lymphoid Cell;Malignant Neoplasms;Measures;Melanoma;Melanoma patient;Melanoma Tumor;Metastatic Melanoma;Mutation;nano-string;Natural Immunity;Newly Diagnosed;novel;Paraffin;Pathway interactions;Patients;peripheral blood;Phenotype;Population;Prognosis;prospective;protein expression;receptor;recruit;Recurrence;Research;Resistance;Resistance development;resistance mechanism;response;Retrospective cohort;Risk;Risk Marker;Role;secondary lymphoid organ;Sentinel Lymph Node Biopsy;Stains;success;Surgical Oncologist;T-Cell Activation;T-Lymphocyte;Tissues;Toxic effect;Training;Treatment Failure;treatment response;treatment strategy;tumor;Tumor Burden;Tumor Escape;tumor microenvironment;tumor progression;tumor-immune system interactions;tumorigenic;Work

PROJECT_TITLE: The frequency and function of Type 3 Innate Lymphoid Cells regulates the melanoma tumor microenvironment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (22)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

PHR: The goal of this proposal is to understand the contribution of abnormal muscle blood flow distribution to decreased functional capacity in DM. Hypothesis: Microvascular perfusion heterogeneity contributes to diabetes mediated muscle fatigue, decreased muscle VO2 and impaired functional exercise capacity and these endpoints will improve with two different agents that improve muscle blood flow distribution -GLP-1 or Nitrites. SA#1: To test the hypothesis that hyperglycemia will cause muscle perfusion heterogeneity, muscle fatigue and decreased muscle VO2 and that GLP-1 and Nitrites will prevent or restore these endpoints. SA#2: To examine the ability of GLP-1 or Nitrites to improve DM FEC and to augment the impact of exercise training. SA#3: To define the importance of GLP-1 receptors for muscle perfusion heterogeneity and function and for the adaptation to exercise training. Impact of these studies on the Veteran Population: Ultimately, improving functional capacity should increase longevity and health-span for people with diabetes.

PI_NAMEs: REUSCH, JANE E (contact)

PROJECT_TERMS: Activities of Daily Living;Acute;Address;Adult;Animals;antagonist;Basic Science;Blood capillaries;Blood flow;Blood Vessels;cardiometabolism;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Clinical Research;Data;density;Diabetes Mellitus;Endothelial Cells;Endothelium;Exercise;exercise capacity;exercise training;experimental study;Functional impairment;functional improvement;GCG gene;GLP-I receptor;glucagon-like peptide;glucagon-like peptide 1;Goals;healthspan;Heterogeneity;Human;Hyperglycemia;impaired capacity;Impairment;improved;in vivo;Intervention;Life Expectancy;life span;Link;Longevity;Measures;Mediating;Microvascular Dysfunction;military veteran;Minor;Modeling;mortality;mouse model;Mus;Muscle;Muscle Fatigue;Muscle Mitochondria;Nitric Oxide;Nitric Oxide Synthase;Nitrites;Oxygen;Oxygen Consumption;oxygen transport;Performance;Perfusion;Persons;Physical activity;Positioning Attribute;pre-clinical;Premature Mortality;prevent;programs;Publishing;Reporting;Research;response;Rodent;Running;Skeletal Muscle;Testing;Tissues;type I and type II diabetes;uptake;Veterans;Youth

PROJECT_TITLE: Targeting Microvascular Contributors to Impaired Functional Exercise Capacity in Diabetes

STUDY_SECTION: ENDA

STUDY_SECTION_NAME: Endocriniology A[ENDA]


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

PHR: PROJECT NARRATIVE Although thousands of RNAs are localized to a variety of subcellular locations, the sequences within those RNAs that regulate their transport are generally unknown. This proposal uses high-throughput techniques to identify and characterize RNA localization regulatory elements with high precision.

PI_NAMEs: MOFFATT, CHARLIE E (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: 3' Untranslated Regions;Ablation;Acylation;Automobile Driving;base;Bioinformatics;Biological Assay;Biological Process;Cell Fractionation;Chemicals;Code;Data;design;Disease;Dissection;Elements;Embryonic Development;Functional disorder;GDF11 gene;High-Throughput Nucleotide Sequencing;Hydroxyl Radical;Knowledge;Language;Length;Location;Maps;Measures;Mediating;Molecular;mutant;Mutation;Nature;Neurites;Neurons;Nucleotides;Oligonucleotides;Physiological;Primer Extension;Process;Regulatory Element;Reporter;RNA;RNA Sequences;RNA Transport;RNA-Binding Proteins;Slide;Structure;Techniques;Testing;trafficking;Transcript;Transgenes;Translational Regulation;Work

PROJECT_TITLE: High-throughput dissection of RNA localization regulatory elements

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The vast majority of ALS patients and roughly half of FTD patients display neuronal inclusions rich in the RNA binding protein TDP43. In previous work, we found that TDP43 splice variants, termed “short” (s)TDP43, are cytosolic in localization and able to sequester full-length TDP43 within disease-like inclusions, pointing to a potential contribution of these isoforms to neurodegeneration. In this proposal, I will define the native RNA and protein interactors for sTDP43 and investigate a potential function for sTDP43 in maintaining RNA homeostasis, thus providing novel insight into the mechanisms by which sTDP43 may drive disease pathogenesis in ALS and FTD.

PI_NAMEs: DYKSTRA, MEGAN  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Adaptor Signaling Protein;Affect;ALS patients;Alternative Splicing;Amino Acids;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotides;Binding;Bioinformatics;Biology;C-terminal;career;Cell Nucleus;cell type;Communication;comorbidity;Coupled;crosslink;Cytoplasm;Cytoplasmic Granules;Data;Data Analyses;Disease;DNA;Event;Exhibits;Experimental Designs;Fluorescent in Situ Hybridization;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;G3BP1 gene;Genes;Glycine;Goals;Homeostasis;immunocytochemistry;Immunoprecipitation;Individual;Induced pluripotent stem cell derived neurons;insight;Introns;Investigation;knock-down;Label;Laboratories;Length;Measures;Mediating;Messenger RNA;Metabolic;Methods;Molecular;Motor Neurons;mRNA Decay;mRNA Precursor;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neuronal Dysfunction;Neurons;next generation;next generation sequencing;novel;novel therapeutic intervention;Nuclear;Nuclear Export;Nuclear Protein;Organelles;Pathogenesis;Pathology;Pathway interactions;Patients;Population;Production;Protein Isoforms;protein protein interaction;protein TDP-43;Proteins;Proteomics;recruit;Regulation;Research Personnel;Response Elements;Ribonucleoproteins;RNA;RNA Binding;RNA Degradation;RNA Recognition Motif;RNA Splicing;RNA Stability;RNA-Binding Proteins;Role;Services;Set protein;skills;stress granule;success;Testing;Toxic effect;training opportunity;Transcript;transcriptome sequencing;Translational Repression;Translations;Variant;Work

PROJECT_TITLE: Identifying the function of alternatively spliced TDP43 isoforms and contribution to disease


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Rheumatoid Arthritis

PHR: Project Narrative This project will investigate the effects of granzyme K-expressing CD8 T cells on fibroblasts in synovial tissue in patients with rheumatoid arthritis. We have detected CD8 T cells with a similar profile in several other diseased tissues, including kidney in lupus nephritis, inflamed bowel in Crohn’s disease and ulcerative colitis, and lung (broncheoalveolar lavage fluid) in severe SARS-CoV-2 infection. Thus, our findings within the context of rheumatoid arthritis may improve our ability to understand, diagnose, and treat many diseases.

PI_NAMEs: JONSSON, ANNA HELENA  (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Advisory Committees;Animal Model;Architecture;Area;Autoimmune Diseases;biobank;Bioinformatics;Biological;career;career development;CCL2 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Clinical;Collagen Arthritis;Complement;Complement Activation;complement system;Computational Biology;Core Facility;Crohn's disease;Cytometry;cytotoxic;Data;Deposition;Development Plans;Diagnosis;dimensional analysis;Disease;Doctor of Philosophy;Exhibits;experience;experimental study;Faculty;Fibroblasts;Flow Cytometry;FRAP1 gene;Frequencies;genetic signature;Goals;granulysin;Granzyme;gut inflammation;high dimensionality;Histology;Human;Image;Immunofluorescence Immunologic;Immunology;improved;In Situ;in vivo;Inflammation;Inflammatory;Inflammatory Arthritis;inflammatory marker;instructor;Interleukin-6;Kidney;Laboratories;Lavage;Link;Liquid substance;Lung;Lupus Nephritis;Lymphocyte;Measures;Mediating;Mediator;Mentors;Mentorship;Metabolic;Metabolism;metabolomics;Microscopy;Modeling;Molecular;mouse model;Mus;Pathogenesis;Pathway interactions;Patients;perforin;Phenotype;Play;Positioning Attribute;Production;Proliferating;Proteins;Reactive Oxygen Species;Reporting;Research;Research Personnel;Reverse Transcriptase Polymerase Chain Reaction;Rheumatism;Rheumatoid Arthritis;Rheumatology;Role;Sampling;SARS-CoV-2 infection;severe COVID-19;single-cell RNA sequencing;skills;Stimulus;Synovial Fluid;Synovial Membrane;Synovitis;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Technology;tenure track;Time;Tissue imaging;Tissue Sample;Tissues;TNF gene;Training;transcriptome sequencing;transcriptomics;translational immunology;Ulcerative Colitis;Wild Type Mouse

PROJECT_TITLE: Architecture and interactions of Granzyme K+ CD8 T cells in inflamed synovium in rheumatoid arthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Serious Mental Illness;Substance Misuse;Suicide;Suicide Prevention;Telehealth

ORG_NAME: BEHAIVIOR INC.

PHR: Project Narrative With staggeringly high relapse and overdose rates and a dearth of treatment access and efficacy, the opioid epidemic is among the most pressing public health concerns of our time; drug craving states can be induced by a number of social, environmental, and contextual cues, there are often comorbidities with mental health issues, and other substance use disorders, and sustained, consistent, permanent behavior change is required to avert potential relapse events. An increasing body of literature identifies United States veterans as extremely vulnerable to opioid addiction and overdose, amongst other mental health related risks; the proposed work entails the development of precision opioid-use related intelligence which presents a unique opportunity to make an impact beyond aiding the process of addiction recovery, to help those struggling with other mental health challenges such as anxiety, PTSD, and suicidal ideation, and includes investigating the potential for physiological and behavioral monitoring of individuals with opioid addictions amongst the US Veteran population in order to improve adherence to treatment for opioid use disorder and aid in reintegration into civilian life. Behaivior will deliver real-time insights from internal and external factors that affect craving states based on wrist wearables and smartphone monitoring technology that can detect high-risk craving states and provide a trusted network of support individuals as well as care coordinators with just-in-time information to facilitate interventions which may avert life-threatening events, including overdoses or suicides.

PI_NAMEs: CALLAN, JUDITH ANN;FORMAN, STEVEN D.;FORSTER, SARAH E;GORDON, ELLIE  (contact)

PROGRAM_OFFICER_NAME: ANGELONE, LEONARDO MARIA

PROJECT_TERMS: addiction;Address;Adherence;Affect;Age;Annual Reports;Anxiety;artificial intelligence model;Award;Behavior;behavior change;Behavior monitoring;Behavioral;care providers;career;Caring;Cellular Phone;Centers for Disease Control and Prevention (U.S.);chronic pain;Clinical Research;cloud platform;Collection;combat;comorbidity;Coupling;COVID-19 pandemic;craving;Cues;Data;Data Reporting;Data Set;design;Development;drug craving;Education;effectiveness evaluation;Epidemic;Event;Face;Feeling suicidal;first responder;Gender Identity;General Population;Goals;Health Services Accessibility;help-seeking behavior;High Prevalence;high risk;Human;improved;Incidence;Income;Individual;Injury;insight;Intelligence;Intervention;Learning;Life;Literature;Machine Learning;machine learning model;Mental Health;mental state;Methodology;Military Personnel;military veteran;Modeling;Monitor;mortality;novel;operation;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose death;Pain;Patient Self-Report;Patients;peer support;Performance;Periodicals;Personal Satisfaction;personalized care;Persons;Phase;Physiologic Monitoring;Physiological;Physiology;Population;Post-Traumatic Stress Disorders;predictive modeling;Process;Production;programs;Public Health;Race;Recovery;Relapse;relapse prevention;remote intervention;remote monitoring;Reporting;research study;Resistance;Risk;Safety;seal;severe mental illness;Small Business Innovation Research Grant;social;social stigma;software as a service;Stress;stressor;substance misuse;substance use;Substance Use Disorder;suicidal;Suicide;Suicide prevention;suicide rate;support network;Surveys;System;Technology;Time;tool;Training;Treatment Efficacy;Treatment Protocols;Trust;United States;United States Substance Abuse and Mental Health Services Administration;Veterans;wearable data;wearable device;Work;Wrist

PROJECT_TITLE: Modeling Physiology and Behavior of Veterans to Avert Opioid Related Mortality Through Timely Intervention


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE The dynamic microtubule cytoskeleton plays vital roles in cell division, motility and differentiation. This project aims to provide a fundamental molecular understanding of dynamic microtubule behavior using a multidisciplinary approach that combines biochemical in vitro reconstitution, live-cell imaging and computational modeling. Because microtubules are a common target for chemotherapeutic agents and many of their regulating proteins are implicated in cancer and neurodegenerative diseases, the proposed research bears critical relevance for both basic science and human health.

PI_NAMEs: ZANIC, MARIJA  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Basic Science;Behavior;Binding;Biochemical;Biophysics;Cell Differentiation process;Cell division;cell motility;Cell Physiology;Cells;chemotherapeutic agent;Computer Models;Cytoskeletal Modeling;Cytoskeleton;experience;experimental study;Feedback;Goals;Growth;Health;Human;human disease;in silico;In Vitro;Individual;insight;interdisciplinary approach;Investigation;Kinesin;light microscopy;live cell imaging;Long-Term Effects;Malignant Neoplasms;mathematical model;Measurement;Microfluidics;Microtubule Polymerization;Microtubules;Modeling;Molecular;Motility;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuron development;Phase;Physiological;Play;Polymers;Process;protein purification;Proteins;reconstitution;Research;Resolution;Role;spatiotemporal;stathmin;Tertiary Protein Structure;Testing;Time;Tubulin;ultra high resolution

PROJECT_TITLE: Biophysical Principles of Microtubule Dynamics

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: SYRACUSE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Project Narrative Mammalian retinas lack an intrinsic regenerative capability, so loss of neurons cause permanent vision loss in humans with neurodegenerative diseases. Recently, progress has been made in engineering mammalian Müller glia to replace lost neurons, however, we have found that the inflammation that accompanies neuronal loss restricts regeneration. In this proposal, experiments are outlined to determine how the neuroimmune system impacts Müller glia-mediated regeneration, with the objective to identify novel strategies for improving the regenerative potential of the mammalian retina.

PI_NAMEs: TODD, LEVI J. (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Ablation;Adult;Blindness;Catalogs;cell type;Cells;Cessation of life;Chick;Collaborations;Data;Disease;Engineering;Equipment;experimental study;Faculty;Fishes;Flow Cytometry;Functional Regeneration;Gene Expression;Genes;Goals;Heterogeneity;Histone Deacetylase Inhibitor;Human;Immune;immune activation;Immune system;Immunohistochemistry;immunoregulation;improved;in vivo regeneration;Individual;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Injury;Interferons;Invaded;Investigation;Knock-in Mouse;Mediating;Microglia;Molecular;Monitor;monocyte;Muller's cell;Mus;N-Methylaspartate;Natural regeneration;nerve stem cell;Neural Retina;Neurodegenerative Disorders;neurogenesis;Neuroimmune;Neuroimmune system;neuroimmunology;neuron loss;neuron regeneration;Neurons;novel strategies;overexpression;Pathway interactions;Peripheral;pharmacologic;Population Heterogeneity;prevent;Process;progenitor;programs;Quality of life;regeneration potential;regenerative;Regenerative capacity;Regenerative response;regenerative therapy;repair strategy;repaired;Reporting;Research;Research Personnel;response;response to injury;Retina;retinal damage;retinal neuron;retinal regeneration;Signal Transduction;single-cell RNA sequencing;stem cell genes;Testing;Therapeutic;Training;Training Activity;transcription factor;Transgenic Mice;Trauma;Universities;Vertebrates;Vision;Washington;Zebrafish

PROJECT_TITLE: Investigation of the neuroimmune axis in retinal regeneration.

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: HUNTSMAN CANCER INSTITUTE PROJECT NARRATIVE Huntsman Cancer Institute (HCI) at the University of Utah is the only National Cancer Institute-designated Cancer Center in Utah and the vast area of the five-state Mountain West; HCI effectively promotes research and public policy to address pressing needs of this region, particularly the special cancer burdens of rural/frontier populations. We care deeply about the next generation of cancer researchers and have implemented a portfolio of programs, including special initiatives for rural and disadvantaged youth. Through the Cancer Center Support Grant, we will make high-impact scientific discoveries across basic laboratory; clinical; and prevention, cancer control, and population-based research, and disseminate these findings to improve outcomes for individuals impacted by cancer.

PI_NAMEs: ULRICH, CORNELIA M (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;anti-cancer research;Area;Award;biobank;Bioinformatics;Biological Assay;Biometry;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Patient;cancer research center director;cancer risk;cancer therapy;career;Caring;Catchment Area;Cause of Death;Cell Differentiation process;cell growth;Cells;Characteristics;Charge;Clinic;Clinical;clinical application;Clinical Data;Clinical Protocols;Clinical Research;Clinical Trials;cohort;Collaborations;college;Communication;community based service;community engagement;Community Outreach;Consultations;data management;Dedications;Development;Direct Costs;Disadvantaged;Doctor of Philosophy;early phase clinical trial;Education;empowerment;Enrollment;Environment;Equity;Exclusion;Extramural Activities;Faculty;faculty mentor;Faculty Recruitment;faculty support;Fostering;frontier;Funding;Genetic;Genetic Counseling;Genomics;Geographic Locations;Grant;Health;health disparity;Health Personnel;Health Professional;Hospitals;Huntsman Cancer Institute at the University of Utah;Idaho;improved;improved outcome;Incidence;Individual;Informatics;innovation;Institution;instrumentation;Intervention;Investigational Therapies;Investments;K-12 Education;Knowledge;Laboratories;Laboratory Research;Leadership;Malignant Neoplasms;Measures;medical specialties;Melanoma;member;Mission;molecular pathology;Monitor;Montana;mortality;National Cancer Institute;National Cancer Institute Cancer Centers Program;Nevada;next generation;Nuclear;organizational structure;Outcome;outreach;patient population;Patients;Peer Review;Population;population based;Population Database;Population Research;Population Sciences;Prevention;Productivity;programs;Protocols documentation;Public Health;Public Policy;Publications;Publishing;recruit;Regulation;Research;Research Institute;Research Personnel;Resource Sharing;Resources;response;Risk;Role;Rural;Science;Services;Shapes;Statutes and Laws;Strategic Planning;Training;Training Programs;Translational Research;Translations;treatment trial;underserved students;Universities;Utah;Work;Wyoming;Youth

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because novel targets and new treatment options for retinal inflammatory diseases are critically needed. Completion of the initiatives proposed will provide new chemical tools that can be employed to advance our understanding of the cGAS-STING pathway in retinal diseases and new hits/therapeutic leads poised for further development/optimization. New therapies with novel mechanisms of action are expected to address the limitations of current therapies, relieve the burden on health care systems worldwide, and improve patient quality of life.

PI_NAMEs: DUERFELDT, ADAM SCOTT (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Address;Adhesions;Affect;Agonist;angiogenesis;Antibodies;Apoptosis;Attention;Attenuated;Autoimmune Diseases;autoinflammatory diseases;bevacizumab;Biochemistry;Biological;Biological Products;Biology;Blindness;Blood capillaries;Blood Vessels;Blood-Retinal Barrier;Cell Death;Cell Physiology;cell type;Cells;Chemicals;Chronic;clinically relevant;Collaborations;common treatment;Complement;Cyclic GMP;Cytosol;Data;design;Development;Diabetes Mellitus;diabetic;diabetic patient;Diabetic Retinopathy;Disease;DNA;DNA Damage;drug discovery;efficacy evaluation;Endothelial Cells;Evaluation;Event;Extravasation;Eye;Fibrosis;Foundations;Funding;glial activation;Health Expenditures;Healthcare Systems;Homeostasis;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;Injections;innovation;Interleukin-6;Ischemia;Knock-out;Knowledge;Leukostasis;macular edema;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Modality;Modeling;monocyte;mouse model;multimodality;Natural Immunity;neovascularization;Neurons;novel;novel strategies;novel therapeutics;Oxidative Stress;Oxygen;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Persons;Pharmaceutical Chemistry;Play;PPAR alpha;Prevalence;Productivity;programs;Protac;Public Health;Quality of life;Refractory;Reporting;Research;Retina;Retinal Diseases;Role;Signal Transduction;Signaling Protein;small molecule;spatiotemporal;standard of care;Stimulator of Interferon Genes;success;synergism;Therapeutic;therapeutic development;therapeutic target;therapy development;tool;Treatment Efficacy;United States;Vascular Endothelial Growth Factors;Vascular Endothelium;White Blood Cell Count procedure;Work

PROJECT_TITLE: Bifunctional Inhibitors of STING as Chemical Probes for Diabetic Retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: AMHERST

ORG_DEPT: DENTISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Periodontitis (PD), cognitive decline and dementias (CD) are prevalent health burdens, with PD affecting approximately 75% of the US population over 65 years of age and CD occurring in more than 40% of those 85 years and older. PD is a chronic inflammatory condition of the tooth-supporting tissue and compelling evidence highlights the relationship of PD with poor systemic health and contributions to cognitive decline and neurodegenerative disorders, of which the periodontal pathogenic bacteria Treponema are linked. In this proposal, we will study cellular pathways targeted by Treponema to promote dysfunction of Blood Bran Barrier and neurovascular cellular components, with the goal to provide new foundational information to further characterize microbial pathogenic mechanisms driving neurological disease to positively impact public health.

PI_NAMEs: MAHAJAN, SUPRIYA DINKAR;VISSER, MICHELLE B (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: 3-Dimensional;Affect;Age;Age Years;Aging;aging population;Alzheimer's Disease;Amyloid Proteins;Architecture;Astrocytes;Automobile Driving;Biological Models;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier function;Brain;brain endothelial cell;Cells;Central Nervous System;Chronic;Clinical;Cognition Disorders;cognitive function;Communication;Communities;cytokine;Data;Dementia;Dental Plaque;Deterioration;Disease;dysbiosis;Early Intervention;Elderly;Endothelial Cells;Functional disorder;Ganglia;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic Transcription;Genomic approach;glial activation;Gliosis;Goals;Health;healthy aging;High Prevalence;Hippocampus;Human;human old age (65+);human very old age (85+);Immunology procedure;Impaired cognition;Impairment;improved;In Vitro;Individual;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;innovation;Internal carotid artery structure;Knowledge;Link;Maintenance;Measurement;Mediating;Microbe;microbial;microbiome;Microfluidics;Microglia;Microscopy;Modeling;Molecular;Morphology;Mus;Names;Nerve Degeneration;Nervous System;Nervous System Disorder;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neuroglia;Neuroimmune;neuroinflammation;Neurologic;neurovascular;neurovascular unit;novel;Oral;oral bacteria;Oral health;oral microbiome;oral spirochetes;Order Spirochaetales;Organism;pathogenic bacteria;Pathogenicity;Pathologic;Pathway interactions;Patients;Pericytes;Periodontitis;periodontopathogen;Permeability;Phenotype;Physiological;Physiology;Play;Population;Prevalence;Proteins;Public Health;Resistance;Resolution;response;Risk Factors;Role;Site;systemic inflammatory response;Testing;Time;Tissue Model;Tissues;Tooth structure;Treponema;Treponema denticola;Trigeminal nerve structure;United States

PROJECT_TITLE: Emerging role of oral spirochetes to promote neuroinflammation and dysfunction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-V (91)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Asthma;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Women's Health Research

ORG_CITY: BLOOMINGTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: NARRATIVE The biological basis underlying sex disparities in asthma, and specifically the roles of estrogen receptors, remain poorly understood. In this proposal, we explore in depth the mechanisms by which estrogen triggers inflammation in the male and female asthmatic lung via the membrane-bound G Protein-Coupled Estrogen Receptor (GPER). Our results will facilitate an enhanced understanding of the molecular basis of hormonal triggers of asthma exacerbations and lead to the potential development of sex-specific therapeutic options.

PI_NAMEs: SILVEYRA, PATRICIA  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Adult women;Affect;Allergens;Allergic;Asthma;asthma exacerbation;asthmatic;asthmatic patient;Binding;Biological;bronchial epithelium;career;chronic inflammatory lung disease;Communication;Coupled;Data;Development;Endocrinology;Epithelial Cells;ESR1 gene;Estrogen Receptor 2;Estrogen Receptors;Estrogens;Extrinsic asthma;Faculty;Female;Functional disorder;Funding;Gonadal Steroid Hormones;GPER gene;Hormonal;House Dust Mite Allergens;Human;Indiana;Inflammation;Inflammatory Response;Knowledge;Laboratories;Lung;Lung Diseases;male;Mediating;meetings;Membrane;men;Mentors;Molecular;mouse model;parent grant;Pathway interactions;Postdoctoral Fellow;Prevalence;pulmonary function;Pyroglyphidae;receptor;Receptor Signaling;Reporting;Research;Research Design;response;Role;Second Messenger Systems;Severities;sex;sex as a biological variable;Sex Differences;sex disparity;Signal Pathway;Signal Transduction;skills;Techniques;Testing;Therapeutic;Training;Transgenic Mice;Universities;Work

PROJECT_TITLE: Sex differences in GPER-mediated mechanisms in allergic asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(53)-R]