NIH_SPENDING_CATS: Biotechnology

PHR: PROJECT NARRATIVE Utilizing tissue microarrays, a large number of tissue cores from donor specimen blocks can be placed (arrayed) into a single recipient block to allow for simultaneous analysis of large tissue cohorts thereby increasing analysis throughput, reducing analysis costs and analytical variability. This proposal requests the purchase of the TMA Grand Master instrument for the Colorado Pathology Shared Resource (PSR) that is capable of automated tissue microarrays construction in an organized, high-density, and high-throughput manner. Utilizing this instrument, the PSR will be able to provide improved streamlined services to researchers and enhance research using archival biospecimen.

PI_NAMEs: VAN BOKHOVEN, ADRIE  (contact)

PROJECT_TERMS: animal tissue;Archives;Area;Basic Science;biobank;cancer genomics;Clinical;clinical infrastructure;Clinical Research;Clinical Trials;cohort;Collaborations;Collection;Colorado;Communities;Computer software;Consumption;cost;Cost Analysis;Cytogenetics;Data;data management;Databases;density;design;design and construction;Development;Diagnostic Procedure;Disease;Documentation;Equipment;equipment acquisition;Equipment and supply inventories;experience;Formalin;Funding;genomic aberrations;Glass;Goals;Histology;Hospitals;human tissue;Image;Immunohistochemistry;improved;Individual;innovation;Institution;instrument;interest;investigator-initiated trial;Knowledge;Logistics;Manuals;Maps;Medical;member;Methods;Modernization;Molecular;Molecular Analysis;Molecular Cytogenetics;molecular pathology;Multi-Institutional Clinical Trial;Normal tissue morphology;Operative Surgical Procedures;Paraffin Embedding;Pathologist;Pathology;Phase;Procedures;Process;Protocols documentation;Quality Control;Reproducibility;Request for Proposals;Research;research and development;Research Design;Research Personnel;Research Project Grants;Research Proposals;research study;Resource Sharing;Resources;Running;Services;Slide;Specific qualifier value;Specimen;Specimen Handling;Standardization;Surgical Pathology;Testing;The University of Colorado Cancer Center;Time;tissue archive;Tissue Embedding;Tissue Microarray;tissue preparation;Tissue Procurements;Tissues;Training;Translational Research;Universities;Validation;Variant;whole genome;Work

PROJECT_TITLE: Pathology Shared Resource Equipment for Automated Construction of Tissue Microarrays


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Biomolecular condensates (BMCs) are compartments formed within cells that contribute to normal biological function but can be dysfunctional in certain diseases, including ALS and FTD. The goal of this project is to create a new class of molecular tools known as PNAs to manipulate and monitor formation of BMCs so that we can better understand the mechanisms by which they form and how their dysregulation can lead to diseases. Our PNAs will accomplish this by targeting specific RNA components of BMCs and either making them fluorescent for visual detection in a microscope or blocking their incorporation into BMCs to study the effect on the cell.

PI_NAMEs: ARMITAGE, BRUCE A. (contact);DONNELLY, CHRISTOPHER JAMES

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Acceleration;Accounting;Affect;Affinity;Alleles;ALS pathology;Amino Acid Sequence;Amyotrophic Lateral Sclerosis;analog;Anti-sense RNA;Antisense Oligonucleotides;Astrocytes;Automobile Driving;Binding;Biochemical Reaction;Biological Models;Biological Process;Biology;biophysical techniques;C9ORF72;Cell Nucleus;Cells;Cellular biology;Cellular Stress;Central Nervous System;Characteristics;Clinical;Clinical Trials;Complex;Cytoplasm;Cytoprotection;cytotoxic;cytotoxicity;Dedications;Defect;design;Detection;Dipeptides;Disease;DNA;effective therapy;Engineering;Environment;Event;experimental study;extracellular;familial amyotrophic lateral sclerosis;fluorescence microscope;Fluorescent Dyes;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;gain of function;Generations;Genes;Genetic;Genetic Transcription;Goals;In Vitro;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Investments;Label;Microscope;microscopic imaging;Microscopy;Molecular;Molecular Probes;Monitor;Morphologic artifacts;Motor Neurons;Neurodegenerative Disorders;Neuroglia;neuron loss;Neurons;neuropathology;novel;Nucleic Acid Hybridization;nucleic acid structure;nucleocytoplasmic transport;Outcome;Pathologic;Pathology;Patients;Peptide Nucleic Acids;Peptides;Phase;Phenotype;phosphodiester;Physical condensation;Play;pre-clinical;prevent;Prevention;protein TDP-43;Proteins;reaction rate;Research;Research Personnel;response;Ribonucleases;RNA;RNA Binding;RNA Sequences;Role;sporadic amyotrophic lateral sclerosis;Stress;sugar;synthetic construct;Testing;Therapeutic;Time;tool;Toxic effect;trafficking;Transcript;Translating;Translations;Vertebral column;Visual;Visualization;Work

PROJECT_TITLE: Peptide Nucleic Acid (PNA) Oligomers for Targeted Disruption of Biomolecular Condensates in ALS/FTD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-L (96)]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

ORG_STATE: MD

PHR: Project Narrative This project provides needed professional development, mentoring, networking, and psychosocial support to allow early-career biomedical researchers from historically excluded groups in science to persist and thrive in a research career, especially in the neuroscience and human physiology fields. This effort will increase the diversity and inclusion of the scientific biomedical workforce, contributing to the national capacity to advance health research outcomes and address scientific challenges.

PI_NAMEs: SEGER, YVETTE RENEE (contact)

PROGRAM_OFFICER_NAME: GIBBS, KENNETH D

PROJECT_TERMS: Address;Advocacy;American;Applications Grants;Award;Awareness;Biological;biological research;Biology;Biomedical Research;Budgets;career;Career Choice;career life balance;Career Mobility;career networking;career preparation;Categories;cohort;Communication;community building;Competence;Complement;Conflict (Psychology);Coupled;data management;Development;Dimensions;diversity and inclusion;early-career faculty;editorial;Educational Curriculum;Educational workshop;empowerment;Environment;Equilibrium;Ethics;Exclusion;experience;Faculty;Feedback;Financial Support;Fostering;Foundational Skills;Functional disorder;Funding;Goals;Grant;Health;Home;Human;improved;Individual;Institution;Journals;Laboratories;Laboratory Scientists;Leadership;Life;Link;meetings;member;Mentors;Mentorship;Modeling;Neurosciences;Outcome;Outcomes Research;Pathway interactions;peer;peer support;Perception;Performance;Personal Satisfaction;Persons;Physiology;Policies;Positioning Attribute;Postdoctoral Fellow;Preparation;programs;promote resilience;psychologic;Psychosocial Assessment and Care;Publications;recruit;Research;Research Personnel;resilience;Resources;response;Role;Safety;Science;Scientific Societies;Series;Services;skill acquisition;skills;Societies;Stereotyping;Structure;Study Section;Support System;Surveys;symposium;Syndrome;Training;virtual;web site;Work;Writing

PROJECT_TITLE: A Federation Approach for the Professional Development of MOSAIC Scholarsin the Biological and Biomedical Sciences

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-V (IP)]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Dissemination and Implementation Research;Genetics;Health Services;Human Genome;Pediatric;Prevention;Primary Health Care

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Genomic medicine seeks to improve clinical outcomes and public health, and identification of clinically actionable inherited genetic conditions before symptoms manifest can enable physicians to intervene earlier and achieve these goals. The newborn screening program exemplifies this paradigm but is limited to a narrow subset of conditions relevant at birth, thereby missing the opportunity to identify many other similarly actionable conditions. Given the many challenges associated with clinical whole genome sequencing in the newborn period, we propose to expand the scope of genomic screening by offering parents targeted sequencing of their children at distinct time-points during development, to discover actionable genetic conditions when that information would have the greatest relevance.

PI_NAMEs: BERG, JONATHAN S (contact);MILKO, LAURA VOGEL

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Address;Adult;Age;age group;Age of Onset;Applied Genetics;Awareness;Benefits and Risks;Biological Assay;Birth;Child;Child Care;Child health care;Childhood;Clinic;Clinical;clinical application;clinical trial implementation;clinically actionable;clinically relevant;Collaborations;Communities;community based participatory research;community engagement;Consensus;Data;Development;Disease;DNA;economic outcome;Ethics;Expert Opinion;Feedback;Future;Genetic Diseases;genetic information;Genetic Medicine;genetic variant;genome sequencing;genome-wide;Genomic medicine;Genomics;Goals;health economics;Healthcare;implementation barriers;implementation evaluation;implementation facilitators;implementation framework;implementation outcomes;implementation protocol;implementation strategy;improved;Individual;infancy;Infant;Inherited;innovation;Intervention;Interview;Laboratories;life span;Longitudinal Studies;Maps;Measures;Medical Care Team;member;Methods;Neonatal Screening;Newborn Infant;novel;Outcome;Parents;Patient-Focused Outcomes;Physicians;Pilot Projects;Population;population health;prevent;Primary Care;primary care setting;Process;programs;Protocols documentation;Provider;Public Health;rare mendelian disorder;reduce symptoms;Research;Resources;screening;screening panel;screening program;social;Specific qualifier value;Symptoms;targeted sequencing;Technology;technology validation;Testing;Time;Treatment Efficacy;Variant;Well Child Visits;whole genome;Work

PROJECT_TITLE: Diversity Supplement: Age-based genomic screening in newborns, infants, and children: a novel paradigm in public health genomics


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Complementary and Integrative Health;Dietary Supplements;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Nutrition;Pediatric;Pregnancy;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Narrative Autism spectrum disorders (ASD) which are characterized by communication deficits and repetitive behaviors affect between 1 and 2% of children in the US and Canada. This study comprehensively investigates several modifiable risk factors of autism and its associated traits including comprehensive measures of folate status and exposure to environmental contaminants such as air pollutants, phthalates, and pesticides. Findings from this work are highly relevant to North American populations and public health agencies and will provide critical information for the potential prevention strategies for autism and its associated traits.

PI_NAMEs: OULHOTE, YOUSSEF  (contact)

PROGRAM_OFFICER_NAME: LAWLER, CINDY P

PROJECT_TERMS: 4 year old;Address;Affect;Air Pollutants;Air Pollution;American;Attenuated;autism spectrum disorder;autism symptoms;autistic behaviour;autistic children;Autoantibodies;Award;biobank;Birth;Blood;Blood specimen;blood-brain barrier crossing;Brain;Canada;Carbon;career development;chemical association;Chemical Exposure;Chemically Induced Neurotoxicity;Chemicals;Child;Cities;Clinical;cohort;Communication;Complex;Complex Mixtures;Cytotoxic agent;Data;Development;Dietary Intervention;Disease;early life exposure;environmental chemical;Environmental Exposure;Environmental Pollutants;Etiology;Europe;Exposure to;Family;First Pregnancy Trimester;Folic Acid;folic acid metabolism;folic acid supplementation;FOLR1 gene;Fostering;Genes;Genetic;Genetic Polymorphism;Genetic Predisposition to Disease;Health;High Prevalence;immune activation;Individual;Infant;Inflammation;Insecticides;instrument;Intake;Intervention;Joints;Life;Link;man;Measurement;Measures;Mediator;Metabolism;Methylenetetrahydrofolate reductase (NADPH);modifiable risk;Mothers;neurodevelopment;Nitrogen Dioxide;North America;Nutritional;Organophosphates;Oxidative Stress;particle;Particulate Matter;personal care products;Pesticides;phthalates;Plasma;Plastics;Play;pollutant;Polyvinyl Chloride;Population;population based;population health;Predisposition;Pregnancy;Pregnancy Trimesters;Pregnant Women;prevent;Prevention strategy;protective effect;Public Health;repetitive behavior;Research;Research Personnel;Risk;Risk Factors;Role;Scientist;social;Statistical Models;System;Testing;Third Pregnancy Trimester;Time;trait;ultrafine particle;Woman;Work

PROJECT_TITLE: The interplay of early life exposure to environmental pollutants and folate system in the etiology of autistic behaviors


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Drug Abuse (NIDA only);Lung;Opioid Misuse and Addiction;Opioids;Patient Safety;Substance Misuse

ORG_CITY: Philadelphia

ORG_NAME: RTM VITAL SIGNS, LLC

PHR: PROJECT NARRATIVE FOR THE PREDICATE PHASE I GRANT. Despite the high prevalence and life- threating nature of opioid induced respiratory depression (OIRD), current strategies to monitor for signs of OIRD are not suitable for deployment for all patients receiving opioids. To address the critical clinical need for technology capable of detecting the onset and progression of OIRD, RTM Vital Signs, LLC is developing a wearable, wireless sensor that continuously monitors a patients’ respiratory patterns to provide actionable alerts. By developing and validating this novel monitoring strategy for OIRD, RTM Vital Signs will ultimately improve patient outcomes and avoid adverse events including hypoventilation, hypoxemia, cardiac arrhythmia, and death.

PI_NAMEs: BOSAK, MAGDALENA KIRLAKOVSKY (contact)

PROGRAM_OFFICER_NAME: ANGELONE, LEONARDO MARIA

PROJECT_TERMS: Acoustics;Address;Adverse event;Algorithmic Software;Algorithms;Apnea;Arrhythmia;body position;Breakthrough device;Breathing;Capnography;Cessation of life;Chronic;Clinical;Clinical Research;Clinical Trials;commercialization;Computer software;detection platform;Development;Devices;Discipline of Nursing;Drug Prescriptions;Environment;Event;Fentanyl;Floor;General Hospitals;Grant;Health;Heart Rate;High Prevalence;Hospitalization;Hospitals;Human;human study;Hypoventilation;Hypoxemia;improved;Incidence;indexing;Life;Measures;Methods;Monitor;Nature;Noise;novel;Operative Surgical Procedures;Opioid;opioid abuse;opioid mortality;opioid overdose;Outpatients;Oxygen;patient safety;Patient-Focused Outcomes;Patients;Pattern;Persons;Phase;Postoperative Period;Prevalence;Prevention;Pulse Oximetry;research clinical testing;respiratory;Risk;sensor;Snoring;sound;System;Technology;Testing;Tidal Volume;Trachea;ventilation;Ventilatory Depression;wearable device;wearable sensor technology;wireless;wireless sensor

PROJECT_TITLE: Wearable Wireless Respiratory Monitoring System that Detects and Predicts Opioid Induced Respiratory Depression


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health

ORG_CITY: ROCHESTER

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OAKLAND UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Problem behavior such as self-injury or aggression engaged in by persons with intellectual and developmental disabilities is a major cause of suffering for them and for their caregivers. Identifying effective treatments that can withstand everyday challenges is therefore of utmost importance. This project investigates a novel tactic for making treatments better able to withstand everyday challenges compared to the current standard-of-care approach, and the project's outcomes could significantly impact care and improve the lives of individuals who engage in problem behavior.

PI_NAMEs: KRANAK, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Address;Aggressive behavior;analog;Attention;Basic Science;Behavior;Behavior Therapy;behavioral economics;Behavioral Model;Caregiver Burden;Caregivers;Caring;Clinical;clinically significant;common treatment;Communication;Communities;community setting;cost;Data;design;Development;effective therapy;effectiveness evaluation;Ethics;Extinction;follow-up;Healthcare;Home;Hospitals;improved;Individual;innovation;Intellectual functioning disability;Measures;Methods;Modeling;Modification;novel;Outcome;Outcomes Research;Participant;Periodicals;Persons;Phase;Population;prevent;Price;Problem behavior;Process;Proxy;Psychological reinforcement;Publishing;Recording of previous events;Recurrence;reinforcer;Relapse;Research;Research Personnel;response;Role;Self-Injurious Behavior;Services;Societies;standard of care;STEM research;System;Testing;Training;treatment effect;Treatment Effectiveness;Treatment Failure;United States;Validation;Work

PROJECT_TITLE: Using Behavioral Economics to Mitigate Relapse of Problem Behavior in an Intellectual and Developmental Disabilities Population

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-H (02)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative-Overall  The primary objective of the State Alzheimer’s Research Support Center (StARS) is to assist states and sub-states build partnerships; successfully develop 1-year pilot projects; and contribute toward a centralized data infrastructure to examine and advance the accessibility, affordability, and effectiveness of integrated/coordinated dementia care services across the U.S. The specific aims are as follows: 1) to establish partnerships to identify existing coordinated/integrated dementia care services and available data sources within states; 2) to successfully support 16 dementia care pilot projects; 3) to build a within- and across state data infrastructure to evaluate dementia care services and policies; and 4) to implement a multifaceted dissemination strategy to promote best practices in the identification, linking, and sharing of dementia care data.

PI_NAMEs: GAUGLER, JOSEPH E. (contact);SAMUS, QUINCY MILES;SHIH, REGINA A

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Acute;Address;Admission activity;advanced dementia;Alzheimer's Disease;Alzheimer's disease related dementia;Award;care coordination;care systems;Caregivers;Caring;Categories;Collaborations;Communities;Consultations;Data;data infrastructure;data resource;data sharing;Data Sources;Dementia;dementia care;Disease;Dissemination and Implementation;dissemination strategy;Effectiveness;Equity;Family Caregiver;Family member;Friends;Health;health care service;Health Disparities Research;health disparity;health equity;Healthcare Systems;Home Care Services;hospital readmission;Hospitalization;improved;Individual;Infrastructure;innovation;integrated care;interest;Knowledge;Learning;Link;Location;Managed Care;member;Modeling;multidisciplinary;National Institute on Aging;Nursing Homes;Outcome;Peer Review;Penetration;Personal Satisfaction;Persons;Pilot Projects;Policies;Policy Analysis;Policy Maker;Population;Process;programs;Provider;Public Health;Publications;Research;Research Support;Resources;Series;Service provision;Services;Social Work;Structure;symposium;System;Trust;underserved community;United States;United States Centers for Medicare and Medicaid Services;Variant

PROJECT_TITLE: The State Alzheimer's Research Support Center (StARS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-S (M4)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: GAUGLER, JOSEPH E. (contact)

PROJECT_TERMS: Address;Admission activity;adverse outcome;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Awareness;Behavioral;Biological;care coordination;care delivery;Caregivers;caregiving;Caring;Chronic;Collaborations;Communication;Communities;community based service;community setting;Complex;Continuity of Patient Care;cost;Data;data infrastructure;data sharing;Dementia;dementia care;dementia risk;Disease;dissemination strategy;effective intervention;Emergency department visit;Ensure;Equity;equity, diversity, and inclusion;ethnic disparity;evidence base;experience;Family;Fostering;Frequencies;Functional impairment;Funding;Goals;Health;health determinants;health disparity;health equity;Healthcare;Home;Hospitalization;Incidence;Individual;Individual Differences;Inequity;Infrastructure;Inpatients;Institutional Review Boards;interdisciplinary collaboration;International;Knowledge;Leadership;Learning;Medical;meetings;Monitor;Newsletter;Nursing Homes;operation;Outcome;outreach;Pattern;Performance;Persons;Pilot Projects;Policies;Process;programs;Provider;Public Health;Published Comment;Quality of Care;racial disparity;Research;Research Personnel;Research Project Grants;Research Support;Resources;Science;service utilization;Services;social;social culture;Structure;Symptoms;tool;United States National Institutes of Health;web site;webinar;Work

PROJECT_TITLE: Admin Core - The State Alzheimer's Research Support Center (StARS)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

PI_NAMEs: FAZIO, SAM  (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Benchmarking;care coordination;care providers;care systems;Caregivers;Caring;Clinical;Collaborations;Communication;Data;Data Sources;Dementia;dementia care;Dementia caregivers;design;Development;Disparate;Ensure;Evaluation;experience;Feasibility Studies;Feedback;Funding;Future;Gender;Geography;Goals;health equity;improved;information gathering;innovation;Interview;Learning;Lived experience;Long-Term Care;Manuscripts;meetings;member;North Carolina;Outcome;payment;Persons;Phase;Pilot Projects;Policies;Policy Making;Privatization;Process;Protocols documentation;Publications;Publishing;Questionnaires;Race;Research;research and development;Research Personnel;Research Support;Resources;Series;Services;Surveys;System;Thinking;Time;tool;Universities;virtual;Voice;web site

PROJECT_TITLE: Partnership Core - The State Alzheimer's Research Support Center (StARS)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: SLOANE, PHILIP D (contact)

PROJECT_TERMS: advanced analytics;African American;Alzheimer's Disease;Alzheimer's disease related dementia;Award;Black race;care coordination;care systems;Caregivers;Caring;Code;Collaborations;collaboratory;Communication;Communities;Complex;Consultations;contextual factors;Data;data access;Data Linkages;data management;data sharing;Databases;Dementia;dementia care;design;Development;direct application;Direct Costs;Ensure;Environment;experience;Funding;Goals;Grant;Grant Review;health disparity;health equity;Hispanic;Hospital Closures;Immigrant;improved;Indigenous;innovation;Latinx;Learning;Lived experience;Modeling;Monitor;multidisciplinary;National Institute on Minority Health and Health Disparities;older adult;Operations Research;Outcome;Pathway interactions;Performance;Persons;Phase;Pilot Projects;Policies;Population;Process;Quality of Care;Research;Research Personnel;Research Support;Resources;Rural Population;rurality;Services;stakeholder perspectives;Structure;Translations;Transportation;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Research Core- The State Alzheimer's Research Support Center (StARS)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: THOMAS, KALI ST. MARIE (contact)

PROJECT_TERMS: Address;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Caregivers;Caring;Catalogs;Communities;Complex;computing resources;Data;data access;Data Analyses;data de-identification;data dictionary;data infrastructure;Data Linkages;data privacy;Data Set;data sharing networks;data warehouse;Dementia;dementia care;Educational workshop;Effectiveness;Equipment and supply inventories;Equity;Evaluation;Face;flexibility;health equity;Home;improved;Infrastructure;Ingestion;Investments;Link;Metadata;multidisciplinary;Outcome;Performance;Persons;Policies;Policy Maker;Prevalence;prevent;privacy protection;Process;programs;Provider;Qualifying;Regulation;Research Personnel;Research Support;Resources;service utilization;Services;Standardization;State Government;Technical Expertise;Work

PROJECT_TITLE: Data Core - The State Alzheimer's Research Support Center (StARS)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative Brigham & Women’s Hospital (BWH), Beth Israel Deaconess Medical Center (BIDMC), Boston Children’s Hospital (BCH), and Massachusetts General Hospital (MGH), four major Harvard teaching hospitals, have joined forces with the Harvard Medical School Division of Medical (HMS-DMS) to form the Harvard Kidney, Urology, and Hematology Training Institute (HKUHTI). The HKUHTI will build off each site’s long-standing successful training track record and will develop courses, professional development, and networking opportunities to cultivate a dynamic and diverse community of lifetime contributors to research and innovation. We aspire to train future global leaders in research, establishing a supportive learning environment that is trainee-focused, collaborative, interdisciplinary, and highly interaction with supportive feedback to trainees and program evolution driven by feedback from trainees and faculty.

PI_NAMEs: ADAM, ROSALYN M;BABITT, JODIE L;BONVENTRE, JOSEPH VINCENT (contact);BRISCOE, DAVID M.;ROSAS, SYLVIA E

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Adult;Area;Attention;Basic Science;Big Data Methods;biological systems;Biotechnology;Boston;career;career development;career networking;catalyst;Childhood;Clinical Research;Collaborations;Communities;Competence;Complement;Dana-Farber Cancer Institute;Data;Data Analytics;Dedications;design;Development;Diabetes Mellitus;digital;Direct Costs;Disease;Ecosystem;Education;education resources;educational atmosphere;Educational Curriculum;Effectiveness;Ensure;Environment;equity, diversity, and inclusion;Ethics;Evaluation;Event;Evolution;experience;Exposure to;Faculty;Feedback;Fostering;Foundations;Funding;Future;General Hospitals;Grant;Growth;Hematological Disease;Hematology;high school;holistic approach;Hospitals;Image;Individual;Industry;innovation;innovative technologies;insight;Institution;Interdisciplinary Study;Israel;Kidney;Kidney Diseases;Knowledge;Leadership;Learning;life span;Manuscripts;Massachusetts;Medical;Medical center;medical schools;Medicine;meetings;Mentors;Methodology;Methods;Minority;Mission;Monitor;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;next generation;novel;novel therapeutics;Outcome;outreach;Pathway interactions;Patients;Pediatric Hospitals;peer;peer coaching;Personal Growth;Pharmacologic Substance;Physicians;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Process;Program Evaluation;programs;Qualifying;Race;Recording of previous events;recruit;repository;Research;Research Personnel;Research Support;Research Training;Resources;response;responsible research conduct;Science;Series;Site;skills;Social Network;socioeconomics;Source;Structure;System;Talents;Teaching Hospitals;Technology;Time;TNFSF15 gene;tool;Training;Training Programs;Translational Research;undergraduate student;United States National Institutes of Health;Update;urologic;Urologic Diseases;Urology;Vision;web site;Woman;Writing

PROJECT_TITLE: Harvard Kidney, Urology and Hematology Training Institute (HKUHTI)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-3 (M1)]


NIH_SPENDING_CATS: Hematology;Kidney Disease

PI_NAMEs: BONVENTRE, JOSEPH VINCENT (contact)

PROJECT_TERMS: Achievement;Address;Adult;Area;Boston;Calendar;career;Childhood;cohort;Collaborations;collaborative approach;Communication;Communities;Consultations;Dana-Farber Cancer Institute;Databases;Dedications;Development;Diabetes Mellitus;Discipline;Education;Educational Curriculum;Ensure;Environment;Equilibrium;equity, diversity, and inclusion;Ethics;Evaluation;Event;experience;Faculty;Feedback;Funding;Future;General Hospitals;Goals;Grant;Hematology;high school;High School Student;Home;Hospitals;improved;Individual;Institution;Instruction;Israel;K-Series Research Career Programs;Kidney;Leadership;Life;Link;Massachusetts;Medical;Medical center;Medical Education;medical schools;Medicine;meetings;Mentors;Mentorship;Methods;Monitor;multidisciplinary;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Non-Malignant;Outcome;Pediatric Hospitals;peer;Postdoctoral Fellow;pre-doctoral;Program Evaluation;programs;Recommendation;Records;recruit;Reporting;Research;Research Personnel;Research Training;Resources;Science;Site;social media;social organization;Source;Structure;success;System;TNFSF15 gene;tool;Training;Training Activity;Training Programs;trend;undergraduate student;Urology;web portal;web site;Woman;Work;Writing

PROJECT_TITLE: Administrative Core


PI_NAMEs: ADAM, ROSALYN M (contact)

PROJECT_TERMS: Adopted;Area;Basic Science;Big Data;Big Data Methods;Biotechnology;Boston;career development;career life balance;career networking;catalyst;Collaborations;Competence;Complement;Course Content;Dana-Farber Cancer Institute;data acquisition;Data Analytics;Databases;design;Development;Diabetes Mellitus;digital;Discipline;Ecosystem;Education;education resources;Effectiveness;Ensure;Entrepreneurship;equity, diversity, and inclusion;Evaluation;Event;Evolution;expectation;experience;Exposure to;Faculty;Funding;General Hospitals;Goals;Grant;health disparity;Hematology;Hospitals;Individual;Industry;innovation;Institution;interdisciplinary collaboration;interest;International;Internet;Israel;Kidney;Laboratories;laboratory experience;Leadership;leadership development;Learning;Manuscripts;Massachusetts;Medical center;medical schools;Medicine;Mentors;Monitor;multidisciplinary;National Center for Advancing Translational Sciences;new technology;Patients;Pediatric Hospitals;peer;programs;Recording of previous events;repository;Research;research and development;Research Personnel;Research Training;Resources;Science;Series;skills;Structure;success;System;Teaching Hospitals;Technical Expertise;Technology;technology platform;Time;tool;Training;Training Programs;Update;Urology;Visualization;Woman;Work;Writing

PROJECT_TITLE: Professional Development


PI_NAMEs: BABITT, JODIE L (contact)

PROJECT_TERMS: American;Area;Award;Awareness;Basic Science;Boston;career development;career networking;Collaborations;Communities;Community Outreach;Country;Coupled;design;Development;Discipline;doctoral student;Ecosystem;Education;Education Projects;Educational workshop;Emerging Technologies;Environment;Evaluation;expectation;Exposure to;Faculty;faculty support;Feedback;Fellowship;Foundations;Funding;Funding Agency;Future Generations;General Hospitals;Grant;Hematological Disease;Hematology;High School Student;Hospitals;Hybrids;improved;Individual;Industry;Infrastructure;innovation;Institution;Israel;Joints;K-Series Research Career Programs;Kidney;Kidney Diseases;Knowledge;Laboratories;Massachusetts;Medical;Medical center;medical schools;Medicine;meetings;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;multidisciplinary;Nephrology;next generation;outreach;outreach program;Patients;Pediatric Hospitals;peer;peer coaching;peer networks;Persons;Postdoctoral Fellow;pre-doctoral;Problem Solving;Process;programs;Recording of previous events;recruit;Research;Research Personnel;Research Training;Resources;role model;Schedule;Scientific Inquiry;screening;screening program;senior faculty;Services;skills;Social Interaction;Social Network;Societies;Source;summer research;Teaching Hospitals;Technology;TNFSF15 gene;Training;Transplantation;undergraduate student;underserved area;United States National Institutes of Health;urologic;Urologic Diseases;Urology;web site;Woman

PROJECT_TITLE: Network Core


ADMINISTERING_IC: AR

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Cachexia;Cancer;Dietary Supplements;Genetics;Natural Products;Nutrition;Physical Activity;Prevention

ORG_CITY: WACO

ORG_NAME: BAYLOR UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative Chemotherapy treatment is associated with a loss of muscle mass and resistance to adaptations to exercise, which are among the most impactful physiologic conditions that survivors face. Although there are various mechanisms by which chemotherapy can negatively affect muscle mass and function, we hypothesize that an accumulation of senescent cells inside of skeletal muscle is a powerful, but under-studied, contributor. Providing insight into the mechanisms driving muscle wasting during cachexia, as well as its treatment, could lead to creative therapeutic avenues to help preserve or restore muscle health and improve quality of life.

PI_NAMEs: DUNGAN, CORY  (contact);WIGGS, MICHAEL PARKER

PROGRAM_OFFICER_NAME: EISENSTEIN, JANA S

PROJECT_TERMS: Address;Adjuvant;Affect;Age;Anti-Inflammatory Agents;Antioxidants;Area;Atrophic;Attenuated;Automobile Driving;Biogenesis;Bioinformatics;Cachexia;Cancer Cachexia;Cancer Patient;Cancer Survivor;cancer therapy;Cell Aging;Cell Death;cell killing;Cell secretion;Cells;chemokine;chemotherapy;Cisplatin;comparison control;Creativeness;cytokine;Data;Disease;DNA Damage;effective intervention;Environment;Excision;Exercise;exercise training;Exhibits;experience;Face;Female;Fiber;fisetin;Flavonoids;Fluorescence-Activated Cell Sorting;Gastrocnemius Muscle;Gene Expression;Growth;Health;healthspan;Hindlimb;Hour;Human;improved;in vivo;indexing;Individual;insight;Insulin Resistance;Intervention;Intraperitoneal Injections;Label;life span;Link;Literature;male;Malignant Neoplasms;Mediating;Metabolic;Metabolism;middle age;Mitochondria;Modeling;Molecular Profiling;mortality;mouse model;Mus;Muscle;Muscle Fibers;muscle form;Muscle function;muscle hypertrophy;Muscular Atrophy;Natural regeneration;Normalcy;novel;novel therapeutic intervention;old mice;Operative Surgical Procedures;Oral;Pharmacologic Substance;Physical Function;Physiological;Plants;Population;preservation;Process;Property;Protein Biosynthesis;Quality of life;Quercetin;Research Design;Resistance;response;Running;sarcopenia;sedentary;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Sex Differences;side effect;single-cell RNA sequencing;Skeletal Muscle;Soleus Muscle;Survivors;Testing;Therapeutic;Therapeutic Intervention;Tissues;transcriptome;Treatment Protocols;Work

PROJECT_TITLE: Utilizing senolytics to enhance the response to exercise in cachectic mice

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE This project will reveal the critical roles of astrocyte-endothelial cell communication in the normal brain and in ischemic stroke by determining how the dynamics of astrocyte anatomy, physiology, and paracrine signaling regulate blood-brain barrier function through molecular, cellular, and physiological mechanisms.

PI_NAMEs: LEE, HYUN KYOUNG  (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Ablation;Address;Adult;Anatomy;Area;Arginine;Astrocytes;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Brain;Cause of Death;CCL2 gene;Cell Communication;cell type;central nervous system injury;Cerebral Ischemia;chemokine;Coupled;Data;Degenerative Disorder;Disease;Endothelial Cells;Endothelium;extracellular;Extravasation;Genetic;Gliosis;Goals;Health;Impairment;in vivo;Infarction;Ischemic Stroke;Knowledge;Maintenance;Malignant Neoplasms;Metabolism;Molecular;Morphology;motor disorder;mouse model;Mus;Nervous System Disorder;Neurodevelopmental Disorder;Neuroglia;novel;Oxides;Paracrine Communication;Pathologic;Pathway interactions;Patients;pH Homeostasis;Physiological;Physiology;Play;post stroke;prevent;Production;Property;Role;Signal Pathway;Signal Transduction;Sodium-Bicarbonate Symporters;Stroke;Transgenic Mice;Variant

PROJECT_TITLE: Deciphering Mechanisms of Astrocyte-BBB Interaction in Normal and Ischemic Stroke

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(91)-S]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Pulmonary arterial hypertension (PAH) is a progressive condition characterized by uncontrolled pulmonary vascular cell proliferation that ultimately leads to right heart failure and death. In this proposal, we will uncover a novel mechanism that is involved in oxidative stress-mediated pulmonary vascular remodeling. This work will test new therapeutics that are targeted to stop pulmonary vascular proliferation attenuating the disease progression.

PI_NAMEs: RAFIKOV, RUSLAN  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Affinity;Animal Model;Antioxidants;Attenuated;attenuation;Binding;Cell Culture Techniques;Cell Proliferation;Cells;Cellular Morphology;Cessation of life;Complex;Cyclin-Dependent Kinase 5;Cytosol;Data;Development;Diagnosis;Disease;Disease Progression;Distal;Endothelial Cells;Endothelium;Event;experimental study;Gene Activation;Gene Expression;Genetic;Goals;Grant;in vivo;insight;Knowledge;Life;Link;Lung;MADH3 gene;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;Medical;Mesenchymal;Metabolic;Mitochondria;mortality;mouse model;Mus;new therapeutic target;nitration;novel;overexpression;Oxidative Stress;Pathologic;Pathway interactions;Patients;Peptides;Phosphorylation;Play;Point Mutation;Pre-Clinical Model;prevent;Proliferating;Proteins;Publications;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular cell proliferation;pulmonary vascular remodeling;Pulmonary Vascular Resistance;Pyruvate Carboxylase;Reporting;Resistance;response;right ventricular failure;Role;Signal Transduction;Stress;Testing;Therapeutic Intervention;therapeutic target;therapeutically effective;Tyrosine;Up-Regulation;Vascular Proliferation;Vascular remodeling;vector;Work

PROJECT_TITLE: Anaplerotic reprogramming of endothelial cells in pulmonary hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Rehabilitation

ORG_CITY: SEATTLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative The processes by which people with cerebral palsy adapt and learn to coordinate their muscles in response to rehabilitation remains unclear. New computational tools from machine learning can be used to understand the mechanisms that drive an individual's response to an intervention and guide treatment. The purpose of this supplement is to model individual responses to feedback training for children with cerebral palsy to support improvements in walking function.

PI_NAMEs: SCHWARTZ, MICHAEL HART;STEELE, KATHERINE M (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Ankle;Biomechanics;causal model;Cerebral Palsy;Child;Complement;computerized tools;Data;Data Science;Engineering;experimental analysis;Exposure to;Faculty;Feedback;Flexor;Future;Gait;Goals;Health;improved;Individual;Individual Differences;individual response;Intervention;Laboratory Research;Learning;light weight;Machine Learning;Mentors;Methods;Modeling;Monitor;Motor;motor learning;Movement;multidisciplinary;multimodality;Muscle;National Institute of Neurological Disorders and Stroke;neuromuscular;novel;Parents;Patients;Pattern;Persons;Positioning Attribute;Process;Recurrence;regression trees;Rehabilitation therapy;Research;Resistance;response;Robot;tenure track;Testing;Time;Training;treadmill training;Walking;wearable device;wearable sensor technology;Work

PROJECT_TITLE: Quantifying patient-specific changes in neuromuscular control in cerebral palsy

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Machine Learning and Artificial Intelligence;Microbiome

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

ORG_STATE: CA

PHR: Project Narrative The human virome, i.e. the collection of viruses found in or on humans, is now primarily explored via metagenomics, which can yield large catalogs of novel virus genomes. Here we plan to develop new tools for taxonomic classification, host prediction, and functional annotation of these novel virus genomes. Building on our experience in establishing some of the foundational viral ecogenomics tools, and leveraging innovative sequence analysis and machine-learning methods, we aim at providing the Human Virome Program consortium with advanced analytics capabilities to better characterize the broad diversity of viruses associated with humans.

PI_NAMEs: KYRPIDES, NIKOS C (contact)

PROGRAM_OFFICER_NAME: MELILLO, AMANDA A

PROJECT_TERMS: Address;advanced analytics;Area;bioinformatics tool;Biological;Biological Assay;Biological Process;Biology;Catalogs;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Communities;comparative genomics;Complex;Computer software;Databases;Detection;Development;Disease;DNA Viruses;drinking;Evaluation;experience;Food;Genes;Genetic;Genome;genome annotation;Genomics;Health;Human;Human body;Human Microbiome;human virome;improved;innovation;Laboratories;Link;Machine Learning;machine learning method;member;metagenome;Metagenomics;method development;Methods;microorganism;Monitor;Neighborhoods;next generation;novel;novel virus;Phenotype;Planet Earth;predictive tools;programs;Protein Family;protein structure prediction;Proteins;Research;Research Personnel;Resolution;Resources;RNA Viruses;Role;Sampling;Sequence Analysis;Shapes;Signal Transduction;Source;Taxonomy;tool;Viral;Viral Genes;Viral Genome;Virus;Virus Assembly;virus classification;virus host interaction;virus identification;virus virus interaction;Work

PROJECT_TITLE: Advanced analytics for uncovering virus dynamics and functional potential

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-X (50)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Screening, diagnosis, and monitoring of disease in internal organs is challenging as tissues are not readily ac- cessible. Endoscopic optical imaging possesses the greatest potential for addressing this problem, but its util- ity is significantly impaired by outdated, problematic endoscope design. The successful development of our metasurface-enhanced endoscope will bring dramatic improvements to the technology while also setting a clear course for future technological innovations.

PI_NAMEs: ADAMS, DAVID C (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TITLE: Non-rotating nano-optic endoscope for 360 degree in vivo imaging

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Microbiome;Networking and Information Technology R&D (NITRD)

ORG_CITY: DAVIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Accurate measurement is essential to understanding any subject, but there is a notable lack of technical precision in commonly used human viromics methods. This proposal will develop, validate, and disseminate rigorous techniques for human viromics research that are applicable to diverse types of human biological samples.

PI_NAMEs: EMERSON, JOANNE  (contact)

PROJECT_TERMS: Address;Adoption;Bacteriophages;Basic Science;Bioinformatics;Biological;Biomass;Classification;Clinical;Clinical Research;cohort;Collaborations;comparative;Computational Biology;Computer Models;Computer software;Computing Methodologies;Consultations;Costs and Benefits;Data;Data Analyses;Disease;DNA;DNA Viruses;Ecology;efficacy evaluation;Engineering;evidence base;experience;Feces;Foundations;Frequencies;Future;Guidelines;Health;Human;Human Microbiome;human virome;in silico;Individual;individual variation;innovation;interest;Laboratories;Link;longitudinal human study;Measurement;medical schools;Meta-Analysis;Metagenomics;Methodology;Methods;microbial community;microbiome;microbiome research;multiple omics;novel;open source;Operative Surgical Procedures;Participant;Pattern;Pilot Projects;programs;Protocols documentation;Publications;Publishing;Recovery;recruit;Research;Resolution;RNA;RNA Viruses;Sampling;Shotguns;Single Stranded DNA Virus;Site;software development;Software Engineering;Soil;stool sample;Structure;Techniques;Technology;training data;Translating;user-friendly;Viral;viral detection;virome;Virus;virus host interaction;Work

PROJECT_TITLE: Establishing laboratory methods for quantitative recovery of diverse DNA and RNA viral sequences from human biosamples


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The identification of gene mutations associated with hearing loss in humans and animal models has contributed greatly to our understanding of cell type specific functions in the inner ear. Experiments in this grant proposal are strongly motivated by the premise that a detailed elaboration of the molecular and cellular mechanisms of cochlear development and function will not only provide better insight into the workings of this complex sensory organ, but may also profoundly change the way inner ear disorders, including hearing loss, are treated in the future.

PI_NAMEs: EPSTEIN, DOUGLAS J (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Acoustic Trauma;Address;Adult;Age;Aging;Anatomy;Animal Model;Applications Grants;ATP phosphohydrolase;Auditory;biobank;Cell membrane;Cell Physiology;Cell Survival;cell type;Child;Childhood;Chromatin;Chronic;Cochlea;cochlear development;Code;cohort;Complex;Data;Defect;Dependence;design;Developed Countries;Diagnosis;Diagnostic;diet-induced obesity;differential expression;DNA Sequence Alteration;DNA Transposable Elements;DNA-Binding Proteins;early onset;Exhibits;experience;experimental study;Failure;Family;flexibility;Functional disorder;Future;Gene Dosage;Gene Expression;Gene Mutation;Gene Targeting;gene therapy;Genes;Genetic;Genetic Predisposition to Disease;genetic risk factor;Genome;genomic tools;Genomics;Goals;Hair Cells;hearing impairment;hearing loss risk;Hearing problem;Heterochromatin;Heterozygote;High Fat Diet;high risk population;High-Frequency Hearing Loss;Homeostasis;Hospitals;Human;human model;imaging approach;immune activation;Immune response;Inflammation;Inflammatory;Inflammatory Response;inner ear diseases;insight;Ions;Knowledge;Labyrinth;Life;Macrophage;Macrophage Activation;Mediating;member;Molecular;Mus;mutant;Mutant Strains Mice;Mutation;Natural Immunity;Neurons;noise exposure;novel;novel therapeutics;Organ;Outcome;Pathogenicity;Pathology;Phagocytes;Phenotype;Population;prevent;prevent hearing loss;Preventive treatment;Process;progressive hearing loss;recruit;Recurrence;Regulator Genes;repaired;Research;Research Personnel;restorative treatment;ribbon synapse;Risk;Role;screening;Sensorineural Hearing Loss;Sensory;Severities;Site;spiral ganglion;stem;System;Testing;Tissues;Variant;Work;Zinc Fingers

PROJECT_TITLE: Pathogenic mechanisms of adult hearing loss caused by Zfp719 mutations

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Microbiome

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE This U01 proposal aims to advance the Human Virome Project by developing and validating innovative technologies that address critical challenges in virome analysis, especially in human tissue samples. Our focus is on the development of Viral-MEM and Viral StochQuant, which are designed to enrich viromes, preserve microbial context, and enhance the accuracy and reproducibility of viral sequencing. These advancements may significantly improve our understanding of the human virome and its interactions with the immune system and the rest of the microbiome, paving the way for new diagnostic and therapeutic approaches.

PI_NAMEs: ISMAGILOV, RUSTEM F (contact)

PROJECT_TERMS: Address;Bacteria;Bacteriophages;Biological;Biomass;Biopsy;Celiac Disease;cohort;Colon;cost effective;cost effectiveness;Data;data integration;data quality;Dedications;design;Detection;detection limit;Development;Disease;DNA;Enhancement Technology;Excision;fungus;Gastrointestinal tract structure;Goals;Health;host-microbe interactions;Human;Human Microbiome;human tissue;human virome;ileum;Immune;Immune system;improved;innovation;innovative technologies;insight;Intestines;Location;Lower Gastrointestinal Tract;Measurement;Methods;Microbe;microbial;microbiome;microbiome research;Noise;novel;novel diagnostics;novel therapeutic intervention;novel virus;Nucleic Acids;Oral;Outcome;particle;Performance;Play;preservation;Process;Rectum;Reproducibility;Research;Research Project Grants;Rest;Role;saliva sample;Sampling;Signal Transduction;simulation;Small Intestines;Structure;Swab;Techniques;Technology;technology validation;Tissue Sample;tool;Vagina;Validation;Viral;Viral Load result;virome;Virus;Work

PROJECT_TITLE: Viral MEM: Viral Enrichment and Precise Stochastic Quantification with Microbial Context Preservation for Rigorous Virome Analysis of Challenging Human Samples


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE There is increasing evidence that differences in responding to everyday visual, auditory, and tactile stimuli are present in infants later diagnosed with ASD, and that attentional patterns (mainly differences in disengaging attention) may explain some of these sensory behaviors in ASD. Comparable research in ADHD is sparse, and because ASD and ADHD share some overlapping causal factors as well as certain early markers, there is a need to examine whether infants developing ASD and/or ADHD show similarities or differences while responding to incoming sensory information early in development and whether links between attentional disengagement and sensory patterns are similar or different across neurodevelopmental disorders. Findings from this study will lead to better understanding of the core and associated symptoms of different neurodevelopmental disorders and provide a route for developing and refining interventions/supports.

PI_NAMEs: KADLASKAR, GIRIJA SUHAS  (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Age Months;associated symptom;Attention;Attention deficit hyperactivity disorder;Auditory;Autism Diagnosis;autism spectrum disorder;autism symptoms;autistic children;Behavior;Behavioral;behavioral response;Caregivers;Child;clinically relevant;Collection;computerized data processing;Data;Development;Diagnosis;Differential Diagnosis;Dimensions;Etiology;experience;Family history of;Foundations;Genetic;Goals;Grant;Individual;individuals with autism spectrum disorder;Infant;interest;intervention refinement;Learning;life span;Link;longitudinal design;Longitudinal Studies;Measures;Mental disorders;National Institute of Mental Health;Neurodevelopmental Disorder;Parents;Pattern;peer;Process;prospective;Questionnaires;recruit;Reporting;Research;response;Risk;Role;Route;Sampling;Sensory;sensory input;sensory stimulus;Severities;Shapes;Siblings;skills;social communication;sound;Source;Speech;Stimulus;Strategic Planning;symptomatology;Symptoms;Tactile;Testing;Time;Touch sensation;trait;Visual

PROJECT_TITLE: Understanding early developmental trajectories of, and mechanisms underlying, sensory reactivity in infants at familial risk for ASD and ADHD

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Genetics

ORG_CITY: Aurora

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: This Project Narrative was originally submitted with R35 GM148198 and is included here unchanged to satisfy submission system requirements. PROJECT NARRATIVE By uncovering molecular mechanisms by which important cytoskeletal proteins assemble into functional units in eukaryotic cells, the proposed research would contribute to fundamental knowledge about the nature and behavior of living systems.

PI_NAMEs: MCMURRAY, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Address;Behavior;Biochemistry;Biology;cell assembly;Cell Differentiation process;Cell Physiology;Cells;Cellular biology;Complex;Cytoskeletal Filaments;Cytoskeletal Proteins;Diffusion;Disease;Eukaryotic Cell;Filament;Gametogenesis;Genes;Genetic;Genetic Transcription;Histones;Individual;insight;Knowledge;Mediating;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;Mutation;Nature;Nucleosomes;Organism;Pathway interactions;Phenotype;Positioning Attribute;Property;protein complex;Protein Complex Subunit;Proteins;Research;Rod;Saccharomycetales;Shapes;Specificity;System;Textbooks;tool;Translating;Translations;Work;Yeasts

PROJECT_TITLE: Step-wise order of assembly of histone proteins into nucleosomes in living cells

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Sleep Research;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: NARRATIVE The latent phase between traumatic brain injury (TBI) and the manifestation of chronic adverse symptoms such as sleep disruption and epilepsy is associated with activation of an innate immune response with concomitant recruitment of systemic immunocompetent cells, such as monocytes and lymphocytes, into damaged brain areas. The goal of the parent proposal is to determine the role of these peripheral immune cells in neural circuit plasticity that promotes sleep disruption and epileptogenesis after TBI. In this diversity supplement application, the goal is for Ms. Vivianna DeNittis to determine the role of a subset of T cells in post-traumatic electrophysiological and behavioral changes after TBI.

PI_NAMEs: PAZ, JEANNE T (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acute;Address;American;Area;Astrocytes;Behavioral;blood-brain barrier penetration;Brain;Brain Injuries;Bypass;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Chronic;Clinic;Cognition;controlled cortical impact;Development;Electroencephalography;Electrophysiology (science);Epilepsy;Epileptogenesis;Event;experimental study;Flow Cytometry;Funding;genetic manipulation;glial activation;Goals;Human;Immune;immune imaging;Immune system;Immunocompetent;Immunology;Immunotherapy;Impaired cognition;in vivo;Infiltration;Inflammation;Injury;Innate Immune Response;Ipsilateral;Lead;Lymphocyte;Macrophage;Mediating;Microglia;Modeling;monocyte;mortality;mortality risk;mouse model;Myelogenous;Nerve Degeneration;neural;neural circuit;neuroinflammation;Neurologic Deficit;neuron loss;Neuronal Plasticity;Neurosciences;novel;Outcome;parent grant;Parents;Patients;Penetration;Peripheral;Phase;Physiology;Play;Population;Post-Traumatic Epilepsy;Recovery;recruit;Risk;Role;Seizures;Sensory;Sleep;Sleep Architecture;Sleep Deprivation;Sleep disturbances;sleep epilepsy;sleep spindle;Slice;Symptoms;Synapses;T-Lymphocyte;T-Lymphocyte Subsets;Talents;Testing;Thalamic structure;Therapeutic;therapeutic target;Three-Dimensional Imaging;tool;Traumatic Brain Injury;wireless;Work

PROJECT_TITLE: Role of Myeloid And CD4+ T Immune Cells in Post-Traumatic Plasticity

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE This proposal is to request funds to purchase four Techniplast Digital VenƟlated Cage (DVC) Isocage NegaƟve systems to upgrade mouse housing, opƟmize husbandry and enhance animal welfare in the shared Animal Biosafety Level 3 (ABSL3) facility at St Jude Children's Research Hospital (SJCRH). This facility is a criƟcal resource for invesƟgators engaged in infecƟous disease and immunity research including the NIAID funded Center of Excellence in Inﬂuenza Research and Response (CEIRR). The goal of this project is to replace the exisƟng 21‐year‐old Mouse Biocontainment rack system with state‐of‐the‐ art Techniplast DVC biocontainment system capable of monitoring rack blower funcƟons with extended back‐up power and capabiliƟes for sensing intra‐cage condiƟons and animal acƟvity for opƟmal delivery of husbandry and veterinary oversight.

PI_NAMEs: PISHARATH, HARSHAN  (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: 2019-nCoV;advanced system;Affect;Aging;Air;Animal Hospitals;Animal Welfare;Animals;Applications Grants;Area;Avian Influenza;Back;Beds;biosafety level 3 facility;Birds;Caring;Child;circadian;Collaborations;Complement;Data;digital;Disease;Ecology;Electric Capacitance;Ensure;exhaust;Faculty;Funding;Future;Goals;Grant;Growth;Holidays;Hour;Housing;Human Resources;humane endpoint;Hypersensitivity;Immunity;Immunology;improved;in vivo;indexing;Individual;Influenza;Laboratories;Laboratory mice;Life;Liquid substance;member;Mission;Monitor;Mus;Natural Immunity;old mice;Pathogenicity;Phase;Play;Policies;Process;programs;recruit;remote monitoring;Research;Research Personnel;Resources;response;Role;Running;Saint Jude Children's Research Hospital;Sampling;Schedule;severe weather;Strategic Planning;Streptococcus pneumoniae;System;Testing;Training;United States Department of Agriculture;ventilation;Viral;Visual;Visual System;welfare;wireless fidelity;World Health

PROJECT_TITLE: Enhancing operational efficiency and animal welfare through the use of digital ventilated caging for laboratory mice in an ABSL3 Select Agent biocontainment program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (91)]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Genetics;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke;Transplantation

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Neuronal loss in neurodegenerative diseases and brain injuries necessitates innovative treatments. While transplanting neural progenitor cells (NPCs) offers therapeutic promise, their limited survival and migration hinder efficacy. To overcome this challenge, we aim to epigenetically reprogram CNS vessels, enabling them to provide survival factors and guidance cues for transplanted NPCs, facilitating the reconstruction of lost circuit connections.

PI_NAMEs: THANKAMANI PANDIT, PEEYUSH KUMAR (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Address;Adult;Affect;angiogenesis;Apoptosis;Area;Attention;behavioral outcome;Blood Vessels;Brain;Brain Injuries;Cerebrum;Clinical;Coculture Techniques;cognitive skill;cohort;Communication;Cues;Data;design;Development;Developmental Gene;Endothelial Cells;Epigenetic Process;Evaluation;functional improvement;Future;gene discovery;Gene Expression;Genes;Genetic;hippocampal pyramidal neuron;histone deacetylase 2;Histone Deacetylase Inhibitor;Image;improved;In Vitro;Infarction;inhibitor;Injections;innovation;insight;Interneurons;Knowledge;Magnetic Resonance Imaging;Measures;Methodology;migration;Migration Assay;Motor Skills;mRNA sequencing;Natural regeneration;Nerve Regeneration;nerve stem cell;Nervous System Disorder;Neurodegenerative Disorders;neuron loss;neuronal guidance;Neurons;neurovascular;novel strategies;Outcome;pharmacologic;Phase;post stroke;post-transplant;prenatal;Process;programs;Proliferating;Publications;reconstruction;Recovery;Recovery of Function;Rejuvenation;Repression;Research;Role;scaffold;stem cell migration;stem cell survival;Stem cell transplant;Stroke;Structure;Supporting Cell;Testing;Therapeutic;Therapeutic Intervention;Transplantation;transplantation therapy;treatment strategy

PROJECT_TITLE: Neuroregeneration after stroke using Vascular Guidance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-V (91)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Rehabilitation

ORG_CITY: CINCINNATI

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative Older individuals are at increased risk for swallowing impairments (dysphagia), and in many remote care settings (e.g. nursing homes, home health) treating clinicians do not have ready access to fluoroscopic imaging equipment for diagnosis, monitoring, and treatment of swallowing disorders. Ultrasound imaging is a promising option that would allow providers and patients to monitor swallowing movements at the bedside, but validity and reliability of ultrasound use to objectively characterize swallowing has not yet been established. This study will provide essential, fundamental evidence validating ultrasound measurements for characterization of swallowing movements, forming the foundation for future improvements in dysphagia treatment.

PI_NAMEs: BOYCE, SUZANNE ELIZABETH;KREKELER, BRITTANY NICOLE (contact);MAST, T DOUGLAS

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Articular Range of Motion;aspirate;Aspiration Pneumonia;Barium swallow;Biofeedback;Biomechanics;Biomedical Engineering;Bolus Infusion;Caring;Choking;Clinic;Clinical;clinical translation;clinically relevant;comorbidity;Coupled;Data;Deglutition;Deglutition Disorders;Dementia;Detection;Diagnosis;Disease;Educational process of instructing;Elderly;Endoscopy;Equipment;Evaluation;Event;Exposure to;Feedback;Fluoroscopy;Foundations;Future;Health;Health Status;high reward;high risk;Home;Image;Impairment;improved;Individual;innovation;instrument;instrumentation;Intervention;Investigation;kinematics;Larynx;Learning;life span;Literature;Lung;Measurement;Measures;Methodology;Modality;Modernization;Monitor;Motion;Movement;Neck;Neurodegenerative Disorders;novel;Nursing Homes;older adult;Older Population;Oropharyngeal;Parkinson Disease;Participant;patient home care;Patients;Pattern;Performance;Persons;Pharyngeal structure;Physiology;point of care;Population;portability;Positioning Attribute;prevent;Provider;Quality of life;Radiation;radiological imaging;Radiology Specialty;real-time images;recruit;Rehabilitation therapy;remote health care;Research;Risk;Safety;Sampling;skills;Source;standard of care;Stroke;Structure;success;Technology;Testing;Therapeutic;Therapeutic Uses;Time;Tongue;tool;Ultrasonography;ultrasound;Validity and Reliability;Vestibule;Visual;Visualization;Visualization software;vocal cord;wireless;Work

PROJECT_TITLE: Ultrasound for bedside characterization of swallowing biomechanical impairments and biofeedback

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Epilepsy;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Sleep Research;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PHR: NARRATIVE Traumatic brain injury (TBI) is a major cause of disability, and leads to sleep disruption and epilepsy over time. The latent phase between TBI and the manifestation of chronic adverse symptoms is associated with activation of an innate immune response with concomitant recruitment of systemic immunocompetent cells, such as monocytes and lymphocytes, into damaged brain areas. The goal of this proposal is to determine the role of these peripheral immune cells in neural circuit plasticity that promotes behavioral and electrographic abnormalities like sleep disruption and epileptogenesis after TBI.

PROJECT_TERMS: Acute;Affect;American;Applications Grants;Area;Astrocytes;automated algorithm;Behavior;Behavior assessment;behavior test;Behavioral;blood-brain barrier penetration;Brain;Brain Injuries;Bypass;career development;CD4 Positive T Lymphocytes;Cells;Chronic;Cognition;Cognitive;controlled cortical impact;Custom;deep learning;Development;disability;Educational Curriculum;Electroencephalography;Electrophysiology (science);Epilepsy;Epileptogenesis;Equity;Event;falls;Flow Cytometry;Funding;genetic manipulation;glial activation;Goals;Human;Immune;immune imaging;Immune system;Immunocompetent;Immunology;Immunotherapy;Impaired cognition;Infiltration;Inflammation;Injury;Innate Immune Response;Ipsilateral;Lead;Learning;Lymphocyte;Machine Learning;Macrophage;Mentors;Microglia;Modeling;monocyte;Motor;mouse model;Mus;Myelogenous;neural;neural circuit;Neurobiology;neuroinflammation;Neurologic Deficit;neuron loss;Neuronal Plasticity;Neurosciences;Outcome;parent grant;Patients;Performance;Peripheral;Phase;Physiology;Play;Post-Traumatic Epilepsy;prevent;Program Development;programs;recruit;Role;Seizures;Sensory;Sleep;Sleep Architecture;Sleep Deprivation;Sleep disturbances;sleep epilepsy;sleep spindle;Slice;Symptoms;Synapses;T-Lymphocyte;Talents;Testing;Thalamic structure;Therapeutic;therapeutic target;Three-Dimensional Imaging;Time;tool;Traumatic Brain Injury;wireless;Work


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE In response to RFA-DA-23-061 we propose “Race & Place: Impacts of Racial Inequality on Substance Use and HIV Outcomes in Los Angeles” to investigate how historically racist policies and practices affect current Black and Latinx Sexual Minority Men in Los Angeles, how the introduction of peer case management may help reduce some of the barriers in terms of access to HIV care, substance use, food and housing, and in turn how these may improve HIV and substance use outcomes. Our team includes the LA LGBT Center, the largest LGBT Serving community site in the country to ensure that evidence-based research is targeted where it in needed the most. Capitalizing upon cross-cutting expertise with academic and community partners to articulate the drivers of the ongoing HIV epidemic among the most vulnerable populations in the US, we will identify strategies to address the intersectionality of this ongoing public health crisis.

PI_NAMEs: GORBACH, PAMINA MAE (contact);JAVANBAKHT, MARJAN ;WINDER, TERRELL

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Address;Affect;anti-racism;Articulation;barrier to care;biobehavior;Black race;California;care outcomes;career;Caring;Case Management;Case Manager;cohort;Cohort Studies;Collaborations;Communities;community based research;community partners;Country;County;Data;design;Disadvantaged;Discrimination;Disparity;Employment;Epidemic;Equity;ethnic minority population;evidence base;Evidence based intervention;experience;Food;food security;Funding;Geography;Harm Reduction;Health;health care availability;health determinants;health outcome disparity;Health Services Accessibility;Healthcare;HIV;HIV disparities;Housing;improved;Incidence;Inequity;insight;Interdisciplinary Study;intersectionality;Intervention;Interview;Latinx;Lesbian Gay Bisexual Transgender;Link;Location;Los Angeles;men of color;Methods;Modeling;Movement;multi-ethnic;National Institute of Drug Abuse;Neighborhoods;novel;Outcome;Outcome Study;Participant;Pattern;peer;Perception;Persons;Pharmaceutical Preparations;Police;Policies;preference;programs;Public Health;Race;racial disparity;racial diversity;Racial Equity;racial health disparity;racial minority;racism;Research;Research Design;Research Infrastructure;Research Personnel;response;Role;Scientist;Security;segregation;Service delivery model;Services;sexual minority men;Shapes;Site;social;social stigma;Space Perception;Stigmatization;structural determinants;Structural Racism;substance use;substance use treatment;Surveys;Territoriality;Test Result;Theoretical model;Theoretical Studies;Transportation;Universities;urban setting;Vulnerable Populations

PROJECT_TITLE: Race & Place: The Impacts of Racial Inequality on Substance Use and HIV Outcomes in Los Angeles

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 TXT-E (M1)]


NIH_SPENDING_CATS: Pediatric

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: PROJECT NARRATIVE Rodents represent around 97% of the vertebrate animals used in biomedical research in the US, yet standard housing guidelines typically expose rodents to cold stress. Growing evidence indicates that the translational value of rodent models of human disease is dependent on housing temperature, a variable seldom controlled for in biomedical research. The goal of this application is to acquire modern rodent housing cabinets that will advance research-related operations within the shared-use rodent metabolic and behavioral phenotyping core at Arkansas Children’s Research Institute. These housing cabinets offer an innovative and energy-efficient mean for breeding, housing, and studying rodents at appropriate housing temperatures.

PI_NAMEs: PORTER, CRAIG  (contact)

PROJECT_TERMS: Accreditation;animal care;animal data;Animal Experimentation;Animal Housing;Animal Husbandry;Animal Model;Animal Welfare;Animals;Arkansas;Award;Behavior monitoring;behavioral phenotyping;Biomedical Research;Body Composition;Breeding;Caring;Child;Clinical;clinical translation;clinically relevant;cold stress;Communities;Core Facility;cost effective;cost efficient;Critical Illness;Data;Dedications;diet and exercise;Disease;Disease susceptibility;energy efficiency;Energy Metabolism;Environment;Exercise Physiology;Failure;Fetal health;Funding;Future;Glucose;Goals;Growth and Development function;Guidelines;Health;House mice;Housing;Human;Human Biology;human disease;human model;Humidity;Infant;Infrastructure;innovation;Institute for Laboratory Animal Research;Institution;Insulin Resistance;Laboratories;Laboratory Animals;light intensity;Lipids;Maintenance;Malignant Neoplasms;Metabolic;Metabolic Diseases;metabolic phenotype;Modernization;Monitor;Mus;Noise;novel therapeutics;nutrition;Obesity;operation;Operations Research;Operative Surgical Procedures;Physiology;pre-clinical;Pre-Clinical Model;pre-clinical research;Procedures;programs;Recommendation;Reproducibility;Research;Research Institute;Research Personnel;Rest;Rodent;Rodent Model;Role;safety testing;Services;success;System;Temperature;Testing;Translations;United States Department of Agriculture;United States National Institutes of Health;Vertebrates

PROJECT_TITLE: Promoting Rigor and Reproducibility in Rodent Models of Metabolic Disease through Thermoneutral Housing


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative  Neurodevelopmental disorders of inattention and disruptive behavior, such as Attention-Deficit/ Hyperactivity Disorder (ADHD) and Oppositional Defiant Disorder (ODD), are among the most common youth conditions worldwide with prevalence estimates at 7% for ADHD and 10% for ODD in Mexico. Left untreated, they contribute to a host of adverse consequences, costing our global society hundreds of billions of dollars each year. Investigating the effectiveness and implementation of feasible, flexible, sustainable, and scalable school clinician training and evidence-based treatment programs supported by clinical research capacity building efforts has the potential to combat the widespread impact of ADHD/ODD, as well as inform future studies of other evidence-based clinician training and intervention programs in real-world, high-need global contexts.

PI_NAMEs: HAACK, LAUREN MARIE (contact)

PROGRAM_OFFICER_NAME: BEKALU, MESFIN AWOKE

PROJECT_TERMS: Address;adverse outcome;Attention deficit hyperactivity disorder;Behavior;Characteristics;Child;Child Rearing;Clinical Research;combat;Communities;Competence;contextual factors;cost;cost estimate;Data;digital;Disease;Effectiveness;effectiveness testing;effectiveness/implementation design;effectiveness/implementation trial;Evaluation;evidence base;Evidence based treatment;Exploration, Preparation, Implementation, and Sustainment;Family;Feedback;flexibility;Fogarty International Center;follow-up;Funding;Future;global health;Goals;Grant;Impairment;implementation determinants;implementation process;implementation science;implementation strategy;improved;inattention;Intervention;intervention effect;intervention program;Left;Life;Maintenance;Mediating;Mexican;Mexico;Mission;Modeling;National Institute of Mental Health;Neurodevelopmental Disorder;novel;Oppositional Defiant Disorder;Outcome;Paper;Parents;Participant;Persons;Prevalence;Program Effectiveness;programs;psychosocial;Public Health;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Research Personnel;Resources;satisfaction;scale up;Schools;Science;services as usual;Severities;skills;Societies;Students;Symptoms;teacher;Technology;Time;Training;Training Activity;Training Programs;Training Support;Translations;treatment program;treatment strategy;Universities;uptake;usability;Work;Youth

PROJECT_TITLE: Hybrid Effectiveness-Implementation Trial of a School Clinician Training and Psychosocial ADHD/ODD Intervention Program Adapted for Schools across Mexico (CLS-A-FUERTE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-L (55)]


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: OVERALL - PROJECT NARRATIVE  Kidney, urology, and hematology all represent areas in medicine with critical needs for additional outstanding investigators to fuel high impact discoveries and treatments in future years. Research training in these areas requires a dedicated community with diverse research expertise, committed mentors who are also outstanding scientists, and training in multiple facets of research conduct. This U2C/TL1 aims to support a network of investigators in San Diego to provide outstanding training and mentorship in kidney, urology, and hematology research.

PI_NAMEs: ANGER, JENNIFER TASH;IX, JOACHIM H (contact)

PROJECT_TERMS: Address;Area;Award;Benign;Biology;Budgets;career;Chemistry;cohort;Collaborations;collaborative environment;Communication;Communities;Dedications;Demography;design;Development;Discipline;Disease;Doctor of Philosophy;Educational Curriculum;Environment;Evaluation;experience;Faculty;faculty mentor;Fellowship;Fellowship Program;Fostering;Foundations;Funding;Future;graduate student;Grant;Hematology;high school;Hispanic-serving Institution;improved;Individual;Infrastructure;innovation;Institution;interest;Internal Medicine;investigator training;Investments;Joints;K-Series Research Career Programs;Kidney;Kidney Diseases;Learning;Link;Manuscripts;matriculation;Medical;medical schools;Medical Students;Medicine;Mentors;Mentorship;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;next generation;Nobel Prize;notch protein;nutrition;Paper;Pathway interactions;Pediatrics;Physicians;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Prevention;programs;Public Health Schools;recruit;Regenerative Medicine;Research;research faculty;Research Institute;Research Personnel;Research Training;Resources;Scholars Program;Science;Scientist;Secure;Series;Services;Source;Structure;Students;success;summer research;Talents;TNFSF15 gene;Training;Training Programs;undergraduate student;Underrepresented Minority;underserved community;United States National Institutes of Health;Universities;urologic;Urologist;Urology

PROJECT_TITLE: The San Diego Regional Network Award for Kidney, Urologic, and Hematologic Research Training


PI_NAMEs: GABBAI, FRANCIS B. (contact)

PROJECT_TITLE: The Administrative Core for The San Diego Regional Network Award for Kidney, Urologic, and Hematologic Research Training


PI_NAMEs: TREJO, JOANN  (contact)

PROJECT_TERMS: Address;Area;Award;career;Clinical Research;Clinical Trials;Collaborations;Communities;Conflict (Psychology);Critiques;Dedications;design;Development;Development Plans;Discipline;Doctor of Philosophy;Educational Curriculum;Environment;equity, diversity, and inclusion;experience;Faculty;Fostering;Funding;Future;Goals;Grant;Health Sciences;Hematology;improved;Individual;Infrastructure;Institution;Kidney;Leadership;Manuscripts;Mediation;Mentors;Mentorship;metropolitan;novel;Oral;peer;Personnel Management;Phase;Postdoctoral Fellow;pre-doctoral;Preparation;Productivity;programs;Reproducibility;Research;Research Institute;Research Personnel;Research Project Grants;Research Training;Science;Services;skills;Structure;Study Section;Teacher Professional Development;Testing;Time Management;TNFSF15 gene;Training;Training Programs;United States National Institutes of Health;Universities;urologic;Urology;Visit;Writing

PROJECT_TITLE: The Professional Development Core for The San Diego Regional Network Award for Kidney, Urologic, and Hematologic Research Training


NIH_SPENDING_CATS: Hematology;Kidney Disease;Pediatric

PI_NAMEs: RIFKIN, DENA EVETTE (contact)

PROJECT_TERMS: Academia;ACVR1 gene;Address;Area;Award;Caliber;career;Career Choice;career development;Clinical Research;Collaborations;collaborative environment;Collection;college;Communities;community engagement;Coupled;Dedications;design;Development;Discipline;Doctor of Philosophy;Education Projects;Educational process of instructing;Educational Status;Environment;experience;Faculty;Fostering;Funding;Future;Goals;Grant;Hematology;high school;high school program;Home;innovation;Institution;interest;Internships;Investments;Kidney;Lead;Learning;Medical;Medical Students;meetings;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Mission;Nephrology;next generation;Participant;peer;peer coaching;Persons;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;programs;Research;research faculty;Research Institute;Research Personnel;Research Training;Resources;Science;Scientist;Source;Students;summer research;support network;symposium;TNFSF15 gene;Training;Training Programs;Translational Research;undergraduate student;underrepresented minority student;Universities;urologic;Urology;virtual;virtual platform

PROJECT_TITLE: The Network Core for The San Diego Regional Network Award for Kidney, Urologic, and Hematologic Research Training


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Regulatory T (Treg) cells are immune cells that mediate recovery from viral pneumonia by modulating the immune response and orchestrating the repair of lung injury. Therefore, understanding how Treg cells exert their protective effects is important for the development of new therapies that target this cell type. Our research seeks to understand the molecular mechanisms through which Treg cells metabolically adapt to the inflamed lung.

PI_NAMEs: TORRES ACOSTA, MANUEL ANDRÉS (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 2019-nCoV;5'-AMP-activated protein kinase;Acetyl Coenzyme A;Amphiregulin;Autoimmunity;Automobile Driving;Biogenesis;Breeding;Carnitine Palmitoyltransferase I;Catalytic Domain;CD4 Positive T Lymphocytes;Cell Lineage;Cell Physiology;Cell Respiration;cell type;Cells;Consumption;COVID-19 pandemic;Data;Development;DNA;DNA Methylation;DNA Methylation Regulation;DNA Modification Methylases;DNA-dependent protein kinase;effector T cell;Engraftment;Environment;Epigenetic Process;epigenetic regulation;Equipment;Eragrostis;Exhibits;experience;experimental study;fatty acid oxidation;Fatty Acids;FOXP3 gene;Functional disorder;Funding;Gene Expression;Generations;Genetic Transcription;Growth;Homeostasis;Hypermethylation;Hypoxia;Immune;Immune response;immune self tolerance;Immunology;immunoregulation;Impairment;In Vitro;in vivo;Inflammatory;Influenza;Influenza A virus;influenza infection;influenza pneumonia;influenzavirus;Knockout Mice;Link;Literature;long chain fatty acid;loss of function;Lung;Lung Diseases;lung injury;lung repair;Maintenance;Mediating;Melanoma Tumor;Mentorship;Metabolic;Metabolic Control;Metabolic stress;Metabolism;Methylation;Mitochondria;Molecular;mortality;mouse model;Mus;Natural regeneration;new therapeutic target;Nutrient Depletion;overexpression;Oxidative Phosphorylation;Oxidative Stress;pathogen;Pathology;permissiveness;pharmacologic;Phosphorylation;Predisposition;Process;promoter;protective effect;Pulmonary Inflammation;Recovery;Recovery of Function;Regulatory T-Lymphocyte;repaired;Research;Resolution;response;Role;Scientist;Specific qualifier value;Stress;subcutaneous;System;Testing;tissue repair;Training;transcription factor;tumor;tumor microenvironment;Viral Pneumonia

PROJECT_TITLE: Metabolic control of regulatory T cells during metabolic stress caused by viral pneumonia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-A(20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: LINCOLN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Project Narrative The proposed research will determine the impact parent-child relationship quality, during the sensitive period of infancy and toddlerhood, on preschool neurocognitive development and subsequent transdiagnostic psychopathology during school age. Additionally, to address the dearth of research on the importance of fathers on children’s development, we will examine the unique contributions of both mothers and fathers in the development and maintenance of children’s psychopathology and its underlying neurocognitive mechanisms. This work has the potential to identify modifiable targets for prevention and intervention efforts in early childhood aimed at reducing executive dysfunction and the subsequent development of nearly all forms of psychopathology across the lifespan.

PI_NAMEs: PHILLIPS, ERIC  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 2 year old;5 year old;7 year old;Address;Affect;Age;caregiving;Child;Child Development;cohort;Communication;critical period;Development;Diagnostic;Dimensions;Disease;early childhood;Early identification;Early Intervention;early onset;emotion dysregulation;Emotional;Etiology;Exclusion;Executive Dysfunction;executive function;Exhibits;experience;Family;Father-Child Relations;Fathers;Impairment;infancy;Intervention;Laboratories;Life;life span;Link;Literature;Maintenance;Measures;Mediator;meetings;Mental disorders;Methods;modifiable risk;Mother-Child Relations;Mothers;negative affect;neglect;Neurocognitive;Neuronal Plasticity;Nursery Schools;Parent-Child Relations;parental influence;Parents;Pathway interactions;Play;Preschool Child;prevent;Prevention;Properdin;Psychopathology;Questionnaires;Reporting;Research;research and development;Risk Factors;Role;Sampling;School-Age Population;Severities;Symptoms;Testing;theories;therapy development;Toddler;Work

PROJECT_TITLE: Neurocognitive Mechanisms Linking Early Parent-Child Relationship Quality to Transdiagnostic Psychopathology at School Age

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Colorectal Cancer;Digestive Diseases;Genetics

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

PI_NAMEs: FISHER, KURT  (contact)

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: anti-cancer;Binding;Binding Proteins;cancer therapy;Cells;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Colorectal Cancer;Data;Development;Disease;DNA sequencing;Epigenetic Process;Gene Expression;Genes;Genetic Transcription;Genomics;Goals;Growth;histone methyltransferase;Histone-Lysine N-Methyltransferase;Homeostasis;Immunoprecipitation;imprint;in vivo evaluation;inhibitor;Injections;KRAS2 gene;loss of function;Mass Spectrum Analysis;Metabolism;metastatic colorectal;Metastatic Neoplasm to the Liver;Modeling;Molecular Biology;Molecular Target;mutant;Mutation;Nebraska;neoplastic cell;novel;Organoids;overexpression;Patients;PPAR gamma;prevent;promoter;Protein Family;protein protein interaction;Proteins;Submucosa;Testing;therapeutic target;Transcription Coactivator;transcription factor;Transcription Initiation;tumor

PROJECT_TITLE: Novel Mechanisms of Inhibiting Transcriptional Coactivators for Anti-Cancer Therapy in Colorectal Cancer


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Post-menopausal women are twice as likely to develop knee osteoarthritis than men; yet there are currently no animal studies aimed at understanding how natural menopause propagates knee osteoarthritis and, thus, no specific treatments for post-menopausal people with knee osteoarthritis. This proposal interrogates the role of pathologic protein turnover in menopause-induced knee osteoarthritis and employs synthetic biology techniques to develop an estradiol-regulated genetic controls circuit. Completion of these studies will provide insight into the underlying mechanisms of menopause-induced knee osteoarthritis and provide the first steppingstone for gene- therapy treatments for this disease.

PI_NAMEs: GILMER, GABRIELLE  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: 4-vinylcyclohexene diepoxide;Address;Adult;adverse event risk;Affect;Age;age related;Aging;alternative treatment;Animal Model;Animals;arthropathies;Attenuated;Biological;biological systems;Cardiovascular Diseases;Cartilage;cartilage degradation;Chemicals;Chondrocytes;Complex;Coupling;Degenerative polyarthritis;design;Disease;Doctor of Philosophy;Dose;Drops;effective therapy;Elements;Engineering;Environment;Estradiol;Exposure to;Feedback;Fellowship;Female;Flow Cytometry;gene therapy;Genes;Genetic;genome wide association study;Goals;Health;Histopathology;hormone therapy;Hormone use;Human;Image;Immunofluorescence Immunologic;Immunohistochemistry;improved;In Vitro;in vivo;Incidence;insight;Institution;interest;International;Intervention;joint injury;Knee;Knee Osteoarthritis;Literature;live cell imaging;male;Mediating;medical schools;men;Menopause;Mentors;Meta-Analysis;middle age;Midlife women;Modality;Modeling;Molecular;multicatalytic endopeptidase complex;multidisciplinary;Mus;Mutation;Orthopedic Surgery;Ovarian Follicle;Ovariectomy;Pathologic;Pathology;Pathway interactions;Performance;Perimenopause;Persons;Phenotype;Physicians;Physiological;Physiology;Postmenopause;Premature Menopause;Process;promoter;protein degradation;Proteins;Proteolysis;Regulation;Rehabilitation therapy;Rejuvenation;Repression;Research;response;Rodent;Role;Scientist;Severities;Sex Differences;Signal Transduction;Societies;Students;synthetic biology;System;Techniques;Testing;Therapeutic;therapy outcome;Thromboembolism;Time;Tissue Engineering;Tissues;tool;Training;Transfection;Ubiquitin;Ubiquitin-mediated Proteolysis Pathway;ubiquitin-protein ligase;Ubiquitination;Universities;Woman;Work

PROJECT_TITLE: Menopausal Knee-ds: Elucidating mechanisms and treatments for knee osteoarthritis


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

ORG_STATE: MD

PHR: The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention, including dietary modification and exercise, in obese Veterans with and without PCC will reduce systemic and adipose tissue inflammation and senescence and promote PCC recovery. This research is especially relevant to older Veterans as two-thirds of Veterans are overweight or obese, rendering excess adiposity a significant risk factor and a high- priority area related to COVID-19 prevention and care. This study also will explore potential mechanisms by which systemic and adipose tissue inflammation and senescence influences the pathophysiology of physical, mental, and social dysfunction in older Veterans recovering from COVID-19. Our findings could lead to novel lifestyle and pharmacologic strategies to optimize COVID-19 recovery.

PI_NAMEs: GRIFFITH, KATHLEEN A;RYAN, ALICE S. (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Adipose tissue;Aerobic;aging related;aging related disease;Area;Baltimore;Behavioral;Biological Assay;Biology of Aging;Body Composition;Body Weight;Caring;Cell Aging;Cell Cycle Arrest;Cell Physiology;Cells;Chronic;clinical implementation;cohort;COVID-19;COVID-19 impact;COVID-19 prevention;cytotoxicity;Diet Modification;disability;Dual-Energy X-Ray Absorptiometry;Dyspnea;ethnic diversity;Etiology;evidence based guidelines;Exercise;Fatigue;Fatty acid glycerol esters;functional decline;Functional disorder;Gait speed;Health;health related quality of life;improved;Individual;Inflammation;Inflammatory;innovation;insight;Intervention;Intramuscular;Laboratories;Life Style;lifestyle intervention;Long COVID;Medical center;men;Metabolic dysfunction;Molecular Profiling;Muscle Weakness;novel;Obesity;Outcome;Overweight;Oxidative Stress;Pain;Participant;Patient Self-Report;persistent symptom;pharmacologic;Phenotype;physical conditioning;Physical Function;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID conditions;post-COVID-19;Predisposing Factor;Prevention;primary outcome;Psyche structure;Randomized;Randomized, Controlled Trials;Recovery;recruit;Rehabilitation therapy;Reporting;Research;response;Risk;Risk Factors;Role;Sampling;SARS-CoV-2 infection;Scanning;senescence;senescence associated secretory phenotype;senescent cell;social deficits;Symptoms;Testing;Thinness;Tissue Banks;Tissues;United States National Institutes of Health;Variant;Veterans;Visceral fat;VO2max;Walking;Weight;weight loss intervention;Woman;X-Ray Computed Tomography

PROJECT_TITLE: Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: PROJECT NARRATIVE Brain-computer interfaces must enable robust and generalizable control of assistive devices in uncontrolled environments, such as the home. Through this proposal, we will study how the physical or cognitive state of a participant impact neural activity and system performance. In addition, we will characterize the extent to which experience- or training-induced motor learning can drive neural plasticity and improve BCI robustness.

PI_NAMEs: COLLINGER, JENNIFER L. (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Acceleration;Automobile Driving;Biomimetics;brain computer interface;Calibration;Clinical;clinical translation;Cognitive;Computer software;Computers;Custom;Data;design;Development;Devices;Dimensions;Disabled Persons;distraction;Elements;Environment;environmental change;Environmental Risk Factor;experience;experimental study;Fatigue;Goals;grasp;Home;Home environment;home test;improved;Intervention;Knowledge;Laboratories;Laboratory Study;Learning;Lighting;Limb structure;Longitudinal Studies;Measures;Monitor;Motion;Motor Cortex;motor learning;Movement;Mus;neural;neural patterning;neuromechanism;Neuronal Plasticity;neurotransmission;Noise;Output;Pain;Participant;Pattern;Performance;Physiological;Population;population based;portability;Positioning Attribute;Posture;Property;Quality of life;response;Self-Help Devices;Signal Transduction;skills;Source;Speed;Stable Populations;Stress;System;Technology;Testing;Time;Training;Translating;Translations;visual tracking

PROJECT_TITLE: Quantifying neural variability and learning during real world brain-computer interface use

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]