ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Substance Misuse;Tobacco;Tobacco Smoke and Health;Tuberculosis

PHR: PROJECT NARRATIVE The purpose of this study is to integrate elements from existing interventions developed by our team into a single intervention (QUIT-AD), designed to improve smoking cessation and favorable HIV/TB treatment outcomes among individuals with HIV and/or TB in Cape Town, South Africa. If feasibility, acceptability, and preliminary efficacy are demonstrated, the intervention will be ready for large-scale effectiveness/implementation testing. This program will has the potential to dramatically improve public health by increasing the smoking quit rate and facilitating favorable HIV/TB treatment outcomes among patients with HIV and/or TB in resource limited South African settings.

PI_NAMEs: O'CLEIRIGH, CONALL MICHAEL (contact)

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: Abstinence;acceptability and feasibility;Acquired Immunodeficiency Syndrome;Acute;Address;Adherence;Administrator;Adult;Affect;Aftercare;antiretroviral therapy;Area;arm;Behavioral;Caring;Cause of Death;Cessation of life;Characteristics;Chronic Disease;Chronic Obstructive Pulmonary Disease;cigarette smoke;Clinic;Cognitive;Cognitive Therapy;comparison control;Counseling;culturally appropriate intervention;Dangerousness;Data;design;Development;Disease Outcome;Distress;effectiveness trial;effectiveness/implementation trial;Elements;Ensure;Epidemic;evidence base;experience;Focus Groups;follow up assessment;follow-up;Funding;Future;future implementation;General Population;Health;high risk;HIV;HIV/TB;implementation intervention;implementation/effectiveness;improved;Individual;innovation;Intervention;intervention refinement;Interview;Link;low and middle-income countries;Lung Diseases;Maintenance;Manuals;men;Modeling;Morbidity - disease rate;mortality;National Institute of Drug Abuse;National Institute of Mental Health;negative affect;Newly Diagnosed;novel;Outcome;Pathway interactions;Patients;peri-urban;Persons;poor health outcome;Prevalence;Procedures;Professional counselor;programs;Protocols documentation;Provider;psychoeducation;Public Health;Pulmonary Tuberculosis;Randomized;Randomized, Controlled Trials;recruit;Relapse;Reporting;Research;Research Personnel;Resource-limited setting;Resources;Risk;Risk Factors;secondary outcome;skills;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking prevalence;Smoking treatment;South Africa;South African;Specific qualifier value;Sputum;Structure;Symptoms;Testing;therapy adherence;therapy development;Tobacco;tobacco abstinence;Tobacco smoke;Tobacco use;treatment adherence;treatment as usual;Treatment Failure;Treatment outcome;treatment strategy;trial comparing;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;United States;Viral Load result;Woman;Work;World Health Organization

PROJECT_TITLE: Treatment Development for Smoking Cessation and Engagement in HIV/TB Care in South Africa


ADMINISTERING_IC: MH

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Primary Health Care;Serious Mental Illness;Suicide;Suicide Prevention

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PI_NAMEs: BROWN, GREGORY K (contact)

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;acute care;Adoption;Ambulatory Care;behavioral health;Caring;Clinical;cluster randomized design;Collaborations;collaborative care;Communities;comparative effectiveness study;compare effectiveness;Consultations;cost;Cost Analysis;cost effective;Counseling;Credentialing;Data;Disparity population;Effectiveness;effectiveness evaluation;Electronics;Emergency Care;Emergency Department patient;Emergency department visit;evidence base;Evidence based intervention;Evidence based practice;follow-up;Frequencies;Future;Health Care Costs;health care settings;Health Services;Health system;high risk;Hospitalization;implementation evaluation;implementation outcomes;implementation research;implementation science;implementation trial;improved;Individual;innovation;inpatient psychiatric treatment;insight;integrated care;Intervention;Licensing;Mediating;Mediation;Medicine;Mental Health;Mental Health Services;Methodology;Minority Groups;Modeling;Monitor;Nature;novel;novel strategies;outpatient programs;Outpatients;patient engagement;Patient Monitoring;Patient-Focused Outcomes;Patients;Phase;Prevention strategy;preventive intervention;primary care patient;Primary Health Care;provider factors;Randomized;reducing suicide;Research;Research Design;Research Personnel;research study;Resources;Risk;risk mitigation;Safety;satisfaction;Self Efficacy;service delivery;Services;Site;suicidal;suicidal behavior;suicidal patient;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;telehealth;Telephone;Time;Training;treatment as usual;United States Department of Veterans Affairs;Veterans;Visit;Writing

PROJECT_TITLE: Signature Project


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Digestive Diseases;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: CORVALLIS

ORG_DEPT: BIOLOGY

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: This project is relevant to public health and the mission of NICHD because it will help determine how handling and pooling practices for human milk fed to preterm infants alter the digestive release of bioactive peptides with gut-health promoting functions. Understanding which milk handling practices will yield the optimal release of bioactive peptides will help guide milk handling practices to best promote healthy development of preterm infants. This proposal specifically addresses two of the NICHD Pediatric Growth and Nutrition Branch’s Research Priorities:1) Human Milk Composition and Function (particularly how milk handling practices affect milk function within the infant) and 2) Nutrition for Preterm Infants (particularly understanding the role of bioactive components of human milk (e.g., peptides) in feeding preterm infants).

PI_NAMEs: DALLAS, DAVID CHARLES (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Address;Affect;Anti-Bacterial Agents;antimicrobial;Childhood;Data;Databases;Development;Digestion;donor milk;Enterocytes;Exposure to;feeding;Fortification;Freezing;Gastrointestinal tract structure;Goals;Growth;Growth and Development function;gut health;Health Promotion;Human Milk;immunoregulation;improved;In Vitro;in vitro activity;in vivo;Infant;innovation;Intestinal Content;Intestines;Knowledge;Macrophage;Mass Spectrum Analysis;Milk;Milk Proteins;Mission;Mothers;National Institute of Child Health and Human Development;Neonatal Intensive Care;Neonatal Intensive Care Units;nutrition;pasteurization;Peptide Hydrolases;Peptides;Premature Infant;preterm newborn;Proteins;Public Health;Qualifying;Research;Research Priority;Research Project Grants;Role;sample collection;Sampling;Source;Structure;Supplementation;Techniques;Testing

PROJECT_TITLE: Effects of human milk handling practices on peptide release and bioactivity in the preterm infant intestine

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Infectious Diseases;Lung;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The Study of HIV Infection in the Etiology of Lung Disease (SHIELD) is a prospective cohort of over 2600 individuals with or at-risk for HIV that has made significant contributions to our understanding that HIV infection is associated with increased respiratory morbidity and lung function impairment. Exposure to air pollution and increased susceptibility to air pollution may contribute to the excess respiratory morbidity among persons living with HIV (PLWH), and we propose to the extend the cohort in SHIELD AIR, which adds innovative approaches to outdoor and indoor air pollution assessment, comprehensive lung function measurement, and novel biomarkers of airway and internal response to exposure. Study findings will provide new insights into modifiable risk factors and targets for interventions aimed at improving lung health for PLWH.

PI_NAMEs: KIRK, GREGORY D;MCCORMACK, MEREDITH C (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acceleration;Acute;Address;Age related comorbidities;Air;Air Movements;Air Pollution;airway epithelium;airway obstruction;Albumins;ambient air pollution;antiretroviral therapy;Baltimore;biobank;Biological;biological adaptation to stress;Biometry;Caring;Chronic;Chronic lung disease;chronic respiratory disease;cigarette smoke;Climate;cohort;Data;Development;Dose;Environmental Exposure;Environmental Health;environmental tobacco smoke;Etiology;experience;Exposure to;Face;fine particles;Funding;Gases;Health;health care service utilization;healthy aging;high risk population;HIV;HIV Infections;HIV Seronegativity;Home;Hospitalization;Household;Household Air Pollution;Immunologics;Impairment;improved;Individual;Indoor Air Pollution;indoor pollutant;Inflammation;Inflammatory;innovation;insight;Intervention;Life Expectancy;Link;Liquid substance;Longitudinal Studies;Lung;Lung Diseases;lung health;lung injury;Mass Spectrum Analysis;Measurement;Measures;modifiable risk;molecular marker;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Nasal Epithelium;National Heart, Lung, and Blood Institute;Nicotine;Nitrogen Dioxide;novel marker;novel strategies;Oxidative Stress;Ozone;Participant;particle;Persons;Physiological;pollutant;Pollution;Population;Predisposition;Prevalence;Prospective cohort;pulmonary function;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonology;Quality of life;Research;Research Personnel;Resolution;respiratory;Respiratory Disease;respiratory health;respiratory morbidity;Respiratory Tract Infections;response;Risk;Risk Factors;Serum;Subgroup;Symptoms;therapeutic target;therapy development;Urine;Vulnerable Populations

PROJECT_TITLE: Study of HIV Infection in the Etiology of Lung Disease (SHIELD) AIR: Air Pollution Impact on Respiratory Health in HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Narrative Mapping networks of protein interactions is central to discovering the mechanisms of disease. This work aims to dramatically improve the specificity and power of technologies for protein interaction discovery, and then apply those methods to explore avenues of research in cancer, neurology, and immunology aimed at establishing new targets for drug development. The data generated through these studies, and also the broader application of these powerful tools, are therefore expected to lead to the development of new therapeutic and diagnostic approaches which will improve human health.

PI_NAMEs: GERI, JACOB  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Affinity;Automobile Driving;Biological Process;catalyst;Cells;Chemicals;Communities;crosslink;Data;Dependence;design;Development;diagnostic strategy;Dimensions;Disease;drug development;Exocytosis;Goals;Health;Human;human tissue;Immunology;improved;interest;ion mobility;Label;Light;Location;Lymphocyte Function;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Membrane;Methods;Microscopy;millisecond;Molecular Biology;Motivation;Neurology;Neurons;new technology;new therapeutic target;novel diagnostics;novel therapeutics;Optics;optogenetics;Orphan;Pattern;Peptides;Proteins;Proteomics;receptor;Research;Resolution;spatiotemporal;Specificity;System;Technology;temporal measurement;Thymus Gland;Time;Tissue Sample;Tonsil;tool;transcriptomics;Work

PROJECT_TITLE: Optically Gated Discovery of Protein-Biomolecule Interactions


NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Suicide;Suicide Prevention

PI_NAMEs: OQUENDO, MARIA A (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;Adoption;Affective;Anxiety;anxious;Assessment tool;Augmented Reality;behavior change;behavior influence;Charge;Code;Cognitive;Cognitive Therapy;Collaborations;Combined Modality Therapy;Communities;Complex;confirmatory trial;Consultations;cost;COVID-19;Data;design;Disparity population;Effectiveness;Evaluation;evidence base;Evidence based practice;experience;Exposure to;Feedback;field study;follow-up;Fright;Goals;high risk;Hospitalization;Iatrogenesis;implementation barriers;implementation context;implementation design;implementation intervention;implementation outcomes;implementation research;implementation strategy;implementation trial;improved;in vivo;Individual;innovation;Intervention;Interview;Legal;Life;Measures;Mental Health;Methods;Mission;Modeling;National Institute of Mental Health;novel;Outcome;Patient risk;Patient-Focused Outcomes;Patients;Phase;pilot test;pilot trial;Play;preventive intervention;prototype;Provider;provider-level barriers;psychoeducation;Questionnaires;Randomized;randomized trial;recruit;relapse prevention;Research;Research Methodology;Research Priority;Risk;Role;Safety;scale up;Scientist;screening;secondary outcome;Self Efficacy;Severities;Standardization;statistics;Stimulus;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Surveys;Technology;Testing;theories;Time;Training;Uncertainty;uptake;virtual reality;Work

PROJECT_TITLE: Exploratory-Project 2


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Heavy drinking places young adults at risk for severe negative consequences (e.g., sexual assault, injuries), and even efficacious interventions have small and short-lived effects. The present study improves upon personalized feedback interventions by using mobile-delivery to provide repeated event-specific personalized feedback delivered close in time to drinking events. This research has the potential to have a major impact on public health by reducing high risk drinking and consequences among young adults, both college and non- college.

PI_NAMEs: MERRILL, JENNIFER ELIZABETH (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: acceptability and feasibility;Address;Age;age group;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol related consequences;alcohol use disorder;Alcohols;Bacterial Artificial Chromosomes;Behavior;behavior change;Behavioral;Blood alcohol level measurement;Cellular Phone;college;Conscious;Data;data quality;design;Dose;drinking;Effectiveness;efficacious intervention;efficacy evaluation;Enrollment;Evaluation;Event;Exclusion;experience;Feedback;financial incentive;follow up assessment;follow-up;Frequencies;Goals;Harm Reduction;hazardous drinking;Heavy Drinking;heavy drinking young adult;high risk drinking;improved;Incentives;Individual;Injury;innovation;Intake;Intervention;intervention effect;intervention participants;intervention refinement;Interview;Memory Loss;mHealth;mobile computing;mobile delivery;Modification;Morbidity - disease rate;mortality;Motivation;normative feedback;novel;Outcome;Overdose;Participant;payment;peer;Perception;Phase;pilot test;Protocols documentation;Public Health;Randomized;Recommendation;recruit;reduced alcohol use;Reporting;Research;response;retention rate;Rewards;Risk;Self Determination;severe injury;sexual assault;smartphone based assessment;Surveys;Testing;Theoretical model;theories;therapy development;Time;university student;Update;Work;young adult

PROJECT_TITLE: Daily personalized drinking feedback delivered via mobile phone

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Health Services;Patient Safety;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Primary Health Care;Rehabilitation

ORG_CITY: LITTLE ROCK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative Falls among older adults are a leading cause of disability, death, and high healthcare costs. This proposal addresses the National Institute on Aging and Healthy People 2030 objectives to develop strategies to reduce falls, their consequences, and fall-related deaths by developing and testing strategies to implement the CDC-developed STEADI (Stopping Elderly Accidents, Deaths, and Injuries) for falls prevention of all older adults attending outpatient rehabilitation. Our proposed research will investigate and test how best to incorporate falls prevention into outpatient physical therapy visits that many older adults already attend and, how to best help older individuals follow the recommendations they receive about how to prevent falls.

PI_NAMEs: VINCENZO, JENNIFER LYNN (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Accidents;Address;Adoption;Adult;Aging;Arkansas;Award;bean;Behavior;Belief;beneficiary;Board Certification;career;career development;Cessation of life;Clinic;Clinical;Clinical effectiveness;Clinical Practice Guideline;Communities;Complement;Consolidated Framework for Implementation Research;Consultations;Data;design;Development;Development Plans;disability;Doctor of Philosophy;effectiveness/implementation hybrid;Elderly;Environment;Equipment;Evaluation;Event;evidence base;Evidence based practice;Exercise;exercise intervention;experience;fall injury;Fall prevention;fall risk;falls;follow-up;formative assessment;Geriatrics;Goals;Guidelines;Health Care Costs;Health Personnel;Health Services;Health system;high risk;Home;human old age (65+);implementation barriers;implementation framework;implementation outcomes;implementation research;implementation science;implementation strategy;implementation/effectiveness;improved;Injury;innovation;Intervention;Interview;Leadership;Learning;Medical;Medicare;Mentors;Mentorship;Methods;mid-career faculty;Morbidity - disease rate;mortality;National Institute on Aging;older adult;Older Population;Outcome;Outpatients;patient-level barriers;Patients;Persons;physical therapist;Physical therapy;pilot test;Positioning Attribute;pragmatic trial;Preparation;Prevention approach;Prevention Research;Primary Care;primary care provider;process improvement;Provider;Qualifying;Randomized, Controlled Trials;Recommendation;Rehabilitation therapy;Reporting;Research;research and development;Research Institute;Research Methodology;Research Personnel;Research Project Grants;Research Support;Risk;Risk Assessment;Risk Management;Safety;Science;screening;skills;Specialist;standard of care;Statistical Methods;Surveys;Testing;Time;Training;Translational Research;Universities;Upper Extremity Fracture;uptake;Visit;Work

PROJECT_TITLE: Developing and testing implementation strategies to support the STEADI for falls risk management in outpatient rehabilitation


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Pulmonary arterial hypertension (PAH) is a severe and often fatal disease, and novel therapeutic approaches targeting the pulmonary vascular remodeling process are desperately needed. Despite intensive research performed on the role of BMP receptors in PAH, only a few BMP ligands have been studied in the context of PAH. The present proposal will aim to investigate the regulation, role and mechanism of action of BMP3 in PAH.

PI_NAMEs: SASSI, YASSINE  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Affect;Age;Animal Diseases;Animal Model;Animals;Apoptosis;Biological Assay;Blood capillaries;BMP3 gene;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;Cardiopulmonary;Cell Communication;Cell Physiology;Cell Proliferation;Cell secretion;Cell Separation;Cells;Cessation of life;Chemicals;Clinical;Co-Immunoprecipitations;Coculture Techniques;Disease;Down-Regulation;Endothelial Cells;Endothelin-1;Equilibrium;experimental study;Exposure to;Functional disorder;Future;Goals;Heritability;Heterozygote;Human;Hypertension;Hypoxia;improved;In Vitro;in vivo;Injury;intercellular communication;Knockout Mice;Ligands;loss of function mutation;LoxP-flanked allele;Lung;MADH2 gene;MADH4 gene;Measurement;member;Messenger RNA;migration;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Mutation;new therapeutic target;novel strategies;novel therapeutic intervention;overexpression;paracrine;Pathogenesis;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Phenotype;Phosphorylation;Pilot Projects;Process;Production;promoter;Protein Overexpression;pulmonary arterial hypertension;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular remodeling;pulmonary vasoconstriction;Rattus;Recombinants;Regulation;Research;right ventricular failure;Rodent;Role;Series;Serum;sex;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Testing;treatment strategy;Up-Regulation;Vascular Diseases;Vascular remodeling;Western Blotting

PROJECT_TITLE: Paracrine Action of BMP3 in Pulmonary Hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Narrative Behavioral and physiological changes driven by severe stress play a major role in numerous human disease states, including post-traumatic stress disorder and related diseases. This proposal uses a circuit-oriented approach to delineate brain mechanisms underlying the behavioral, physiological and molecular impact of traumatic stress, as a means of providing insight into processes that may be leveraged for treatment or prevention of stress pathologies.

PI_NAMEs: HERMAN, JAMES P (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Address;Amygdaloid structure;Anatomy;Animals;Anterior;Attenuated;Automobile Driving;Behavior;Behavior Control;Behavioral;behavioral plasticity;Bioinformatics;Biological;biological adaptation to stress;Brain;cell type;Chemosensitization;cingulate cortex;conditioned fear;Cues;Data;Data Set;design;designer receptors exclusively activated by designer drugs;Development;Dimensions;Disease;Drug Targeting;Electrophysiology (science);emotion regulation;Emotional;Experimental Designs;Exposure to;Extinction;fear memory;Female;Fright;Functional disorder;Genes;genetic approach;Genomics;Health;Hippocampus;Homologous Gene;Human;human disease;IL2 gene;Image;Immediate-Early Genes;Impairment;Individual;Informatics;insight;Interneurons;Intervention;Knowledge;Learning;learning extinction;Link;Maintenance;maladaptive behavior;male;Maps;Mediating;men;Modeling;Modification;Molecular;multiple omics;Negative Valence;neural circuit;Neuronal Plasticity;Neurons;optogenetics;Output;Parvalbumins;Pathologic;Pathology;Personal Satisfaction;pharmacologic;physical conditioning;Physiological;Play;Post-Traumatic Stress Disorders;Prefrontal Cortex;prevent;Prevention;Process;Proteins;Proteome;Proteomics;Rattus;recruit;Regimen;Research;response;Rodent;Role;sex;Signal Transduction;Stress;stress reduction;stress resilience;Synapses;synaptic function;Testing;transcriptome sequencing;trauma exposure;traumatic stress;Viral Vector;Woman

PROJECT_TITLE: Cortical Mechanisms of Traumatic Stress

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Thrombosis is the leading cause of mortality in patients with myeloproliferative neoplasms (MPN), yet little is understood about the mechanism driving this increased risk. Hypoxia-inducible factor (HIF)-mediated upregulation of genes including tissue factor in neutrophils from MPN patients associates with thrombosis history. This proposal aims to evaluate the role of HIF in MPN-associated thrombosis.

PI_NAMEs: REEVES, BRANDI N (contact)

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: Advisory Committees;Alleles;Attenuated;Automobile Driving;Award;Blood Cell Count;Blood Cells;Blood Platelets;blood rheology;Blood Vessels;career;Caring;Cells;Circulation;Coagulation Process;Data;Diagnosis;Docking;driver mutation;Endothelial Cells;Endothelium;Event;Exhibits;experience;Fibrinolysis;Foundations;Functional disorder;Funding;Gene Dosage;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;genetic variant;Genotype;Goals;Hematopoietic;Hemorrhagic Thrombocythemia;Hemostatic Agents;Heterogeneity;Heterozygote;Hypoxia;Hypoxia Inducible Factor;Hypoxia-Inducible Factor Pathway;improved;Incidence;Individual;inhibitor;Injury;insight;Investigation;K-Series Research Career Programs;Leukocytes;Measures;Mediating;Mentors;Modeling;mortality;mouse model;mRNA Expression;Mus;Mutate;Mutation;Myeloid Cells;Myeloproliferative disease;neutrophil;new therapeutic target;normoxia;Pathogenesis;Pathologic;Pathway interactions;Patients;Pericytes;Physicians;Physiological;Plasma;Plasminogen Activator Inhibitor 1;Polycythemia Vera;Population;Positioning Attribute;Prevention;Prevention strategy;Primary Prevention;protein expression;Publications;Recording of previous events;Reporting;Research;response;Risk;Role;Scientist;Secondary Prevention;Series;single cell mRNA sequencing;single-cell RNA sequencing;skills;Somatic Mutation;Source;standard of care;Stimulus;Surface;Testing;thromboinflammation;Thrombophilia;Thromboplastin;Thrombosis;thrombotic;Thrombus;Training;Training Programs;Transgenes;translational study;Up-Regulation;Venous;Venous Thrombosis;Work

PROJECT_TITLE: Hypoxia-Inducible Factors and Neutrophil Heterogeneity in Myeloproliferative Neoplasm-Associated Venous Thrombosis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: DALLAS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative In this proposal, we will characterize the trajectories of outcome in early course psychotic disorders treated in coordinated specialty care programs. We will also identify clinical and biological features, and biological subtypes of psychotic disorders that may help predict outcome.

PI_NAMEs: TAMMINGA, CAROL A (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Accounting;Age Years;Biological;Biological Markers;biomarker development;biomarker identification;biotypes;Bipolar Disorder;Boston;care outcomes;care systems;Categories;Chronic;Clinic;Clinical;clinical practice;clinical predictors;Cognition;Cognitive;cognitive function;Communities;community setting;Coordinated Specialty Care;cost;Data;Data Collection;design;Diagnosis;Diagnostic;Dimensions;Disease remission;early detection biomarkers;Early Intervention;early psychosis;early satiety;Electroencephalography;Enrollment;Eye Movements;follow-up;functional decline;functional outcomes;Funding;Goals;Grant;Heterogeneity;Image;imaging biomarker;Impaired cognition;Impairment;improved;improved outcome;Individual;individual variation;Intervention;Measures;medical specialties;meetings;Modeling;Multivariate Analysis;Neurobiology;Neurocognition;Neurocognitive;neuroimaging;Neurosciences Research;Onset of illness;Outcome;outcome prediction;Participant;Patients;pharmacologic;Phenotype;phenotypic biomarker;Population;Population Characteristics;prediction algorithm;Predictive Value;Procedures;prognostic value;programs;Psychoses;psychosocial;psychotic;Psychotic Disorders;Recovery;recruit;Resources;response;Sampling;Schizoaffective Disorders;Schizophrenia;Schizophreniform Disorder;Services;Site;Stimulus;Structure;Subgroup;Substance abuse problem;success;Testing;Therapeutic Intervention;therapy resistant;Time;treatment adherence;treatment planning;treatment program;Variant

PROJECT_TITLE: 1/5 - Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Neutrophil migration and inflammation are associated with many chronic human conditions and diseases, such as allergies, atherosclerosis, cancer, arthritis, autoimmune diseases, wound healing, and others. This proposal seeks to identify novel molecules that regulate neutrophil migration and characterize their signaling mechanisms, which ultimately lead to novel methods in managing inflammation and treating those upper mentioned diseases.

PI_NAMEs: DENG, QING  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Acute;Address;Adhesions;Arthritis;Atherosclerosis;Autoimmune Diseases;Biological Process;cell type;Cells;Cellular biology;Chronic;combat;Disease;Effector Cell;gene network;Generations;Genes;Genetic;Glycolysis;Health;Homeostasis;Human;Hypersensitivity;Immunology;in vivo;Infection;Inflammation;Inflammatory;inhibitor;Injury;Innate Immune System;Lymphocyte;Malignant Neoplasms;Mediating;Methods;MicroRNAs;migration;miRNA expression profiling;Mitochondria;Modeling;Mus;neutrophil;novel;novel therapeutics;Prevention;Production;Redness;restoration;Role;Signal Transduction;Site;Small RNA;Swelling;Therapeutic;tissue injury;Tissues;tool;Work;wound healing;Zebrafish

PROJECT_TITLE: Neutrophil migration and inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative While the opioid epidemic and opioid-overdose related deaths have affected every demographic population, women, particularly criminal justice-involved (CJI) women, have been severely impacted. This proposal focuses on developing and implementing a gender-specific intervention that provides overdose response training and links and retains CJI women into medication- assisted treatment (MAT).

PI_NAMEs: JONES, ABENAA ACHEAMPONG (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: addiction;Address;Adverse effects;adverse outcome;Affect;Age;Behavior Therapy;career;Caring;Cessation of life;Clinical Trials;Communities;comorbidity;cost;Criminal Justice;design;Disparity;Disproportionately impacts women;drug abuse prevention;Drug Addiction;drug structure;Drug usage;dual diagnosis;effective intervention;evidence base;Evidence based intervention;Fentanyl;Gender;Goals;Health;Health Care Costs;health disparity populations;Health Personnel;Health Services;Hepatitis C Transmission;Heroin;high risk;high risk population;high risk sexual behavior;HIV;HIV risk;HIV/AIDS;HIV/HCV;illicit opioid;Imprisonment;Improve Access;improved;Individual;International;Intervention;Interview;Jail;Justice;Left;Link;male;marginalized community;Medical;medication-assisted treatment;men;Mentors;minority disparity;Minority Women;National Institute of Drug Abuse;National Institute on Minority Health and Health Disparities;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid mortality;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose death;parole;peer;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;Population;Poverty;prescription opioid;Prevention;Prisons;probation;public health priorities;Randomized, Controlled Trials;recidivism;recruit;reduced substance use;Research;Resources;response;Risk Behaviors;Sampling;sexual victimization;skills;social;social factors;Social outcome;Social support;Social Work;societal costs;sociodemographic group;substance use;Substance Use Disorder;Supervision;synthetic opioid;System;therapy design;Training;Trauma;treatment program;United States;violence exposure;virtual;vulnerable community;Woman;Women's mortality;women's outcomes;Women's prevalence;Work

PROJECT_TITLE: Opioid Use Disorder among Criminal Justice-Involved Women: Integrating Trauma-Informed and Gender-Specific Care with Medication-Assisted Treatment

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Contraception/Reproduction;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_DEPT: NUTRITION

PHR: Project Narrative This research has enormous potential to impact public health by providing a simple, low-cost tool for assessing placentas and incorporating diagnoses into clinical care in the highly sensitive time for mother and newborn immediately following birth. Broad implementation of this software could contribute to improved knowledge of the placenta and better maternal/child health outcomes, as well as connecting more clinicians to the use of important placental diagnoses.

PI_NAMEs: GERNAND, ALISON D (contact);GOLDSTEIN, JEFFERY A;WANG, JAMES Z

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Address;adverse outcome;Algorithms;Artificial Intelligence;artificial intelligence model;Assessment tool;Biological Sciences;Birth;Birth Weight;Caring;Characteristics;Chicago;Child;Chronic Disease;Clinical;clinical care;Clinical Data;clinically significant;Computational Technique;Computer software;Computer Vision Systems;cost;Data;data mining;Data Set;design;Devices;Diagnosis;digital;digital imaging;Discipline of obstetrics;Engineering;Environment;Ethnic Origin;Event;Fetal Development;Fetus;Future;Gestational Age;Glean;Goals;Health;health of the mother;Healthcare;Hemorrhage;Hospitals;Image;improved;Income;Infant;Infection;Informatics;intraamniotic infection;Kidney;Knowledge;Life;Lighting;Link;Liver;Low income;Lung;Maternal and Child Health;mathematical model;Measures;Medical;Medical Informatics;Membrane;Morbidity - disease rate;Morphology;mortality;Mothers;multidisciplinary;neglect;Newborn Infant;novel;open source;Organ;Outcome;overtreatment;Pathologist;Pathology;Pathology Report;Patients;Photography;Placenta;Placenta Diseases;Placentation;Population;Pregnancy;Process;Protocols documentation;prototype;Public Health;Race;Research;Research Personnel;Resources;Retained Placenta;Risk;Scientist;screening;Sensitivity and Specificity;Sepsis;sex;Shapes;Site;software development;Software Validation;Standardization;Technology;Testing;Time;tool;Training;Uganda;Umbilical cord structure;Variant;Visual;Woman;Work

PROJECT_TITLE: Development of Software to Rapidly Assess Placenta Images at Birth

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Hispanic men and children experience health disparities for overweight and obesity-related medical conditions, and therefore family level obesity prevention programs for Hispanic populations are urgently needed. ‘Healthy Dads Healthy Kids’ is the first program to primarily target fathers for obesity prevention for themselves and their children, with significant and clinically relevant treatment effects. We propose an efficacy trial to assess a culturally adapted ‘Healthy Dads Healthy Kids’ for Hispanic families among a Medicaid and Children’s Health Insurance Plan sample of Hispanic families.

PI_NAMEs: O'CONNOR, TERESIA MARGARETA (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: 11 year old;Acculturation;Age;Australia;Award;Behavior;behavior change;Behavior Therapy;Behavioral;Biological;Blood Pressure;Body mass index;Body Weight decreased;Cardiovascular Diseases;cardiovascular disorder risk;Cause of Death;Child;Child Health;Child Rearing;Childhood;Clinic;Clinical;clinically relevant;Cognitive;cohesion;community partners;community setting;comparison control;Control Groups;Diabetes Mellitus;Diagnosis;Dietary intake;Dimensions;dissemination trial;Eating Behavior;Effectiveness;efficacy evaluation;efficacy study;efficacy trial;Enrollment;evidence base;Evidence based program;experience;Face;Family;Fathers;feasibility testing;feasibility trial;follow-up;Food;Future;Goals;Guidelines;health disparity;Health Insurance;health plan;Healthy Eating;healthy lifestyle;healthy weight;Hispanic;hispanic community;Hispanic Populations;improved;innovation;Intervention;Language;Life Style;Literature;male;media use;Mediating;Medicaid;Medical;member;men;Metaphor;Methods;middle childhood;Modeling;Moderate Exercise;Modification;Mothers;National Heart, Lung, and Blood Institute;Not Hispanic or Latino;novel;novel strategies;Obesity;obesity in children;obesity prevention;optimal treatments;Outcome;Overweight;Participant;Persons;Physical activity;Population;Prevalence;Prevention program;primary outcome;process evaluation;programs;Psychological reinforcement;psychosocial;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Risk;Risk Factors;Risk Reduction;Sampling;satisfaction;secondary outcome;sedentary;social;social cognitive theory;standard of care;Strenuous Exercise;systematic review;Systems Theory;Testing;Texas;Time;treatment effect;United States;Waiting Lists;Weight;weight loss program;Weight maintenance regimen;Woman;Youth

PROJECT_TITLE: EFFICACY TRIAL OF A PROGRAM FOR WEIGHT LOSS FOR HISPANIC FATHERS AND INCREASED PHYSICAL ACTIVITY FOR THEIR CHILDREN: HEALTHY DADS, HEALTHY KIDS

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]


NIH_SPENDING_CATS: Biotechnology

ORG_DEPT: CHEMISTRY

PHR: Project Narrative The development of new synthetic methods for incorporation of medicinally important chemical moieties continues to drive new drug discovery. To this end, this research seeks to combine two transformative advances in chemical synthesis, biocatalysis and C–H functionalization, to develop new metalloenzymes that can convert ubiquitous C–H bonds in organic molecules into functional groups with high biomedical relevance. These newly created biocatalysts will offer powerful tools for drug synthesis and diversification and enable a more expansive chemical space of bioactive molecules that is beyond the reach of current small molecule catalysts.

PI_NAMEs: HUANG, XIONGYI  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Anabolism;Biochemical;Biochemistry;Biological;Biology;Catalysis;catalyst;chemical synthesis;Chemicals;Collection;Computer Models;Development;drug development;drug discovery;drug synthesis;Enzymes;Evolution;functional group;Genetic;Hydrogen Bonding;Knowledge;Medicine;metalloenzyme;method development;Methods;mimetics;Molecular;novel therapeutics;Organic Synthesis;Process;programs;Protein Engineering;Proteins;Reaction;Research;small molecule;System;tool

PROJECT_TITLE: A Chemo-Mimetic Platform to Reprogram Metalloenzymes for Non-Natural Biocatalytic C-H Functionalization Reactions


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: The precise localization of specific channels within the membrane of neurons plays a critical role in their normal functioning, while its disruption contributes to the emergence neurological disease. This project will develop tools to study how channels are localized within neurons and characterize their role in neuronal function. This will further the understanding of how neuronal physiology contributes to health and disease.

PI_NAMEs: GABBIANI, FABRIZIO  (contact);HEINKENSCHLOSS, MATTHIAS

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Address;Algorithms;Anatomy;Area;Behavior;Biological;Biological Models;biophysical analysis;Biophysical Process;biophysical properties;Calcium Channel;Cognition;Cyclic Nucleotides;Data;Dendrites;Development;Disease;dynamic system;Electrophysiology (science);Experimental Designs;experimental study;Formulation;Generations;Health;Hippocampus;in vivo;Individual;information processing;Internet;Ion Channel;Knowledge;Light;mathematical methods;Mathematics;Membrane;Methods;Modeling;Nervous System Disorder;Neurons;Neurosciences;Neurosciences Research;Non-linear Models;open source;Parameter Estimation;Physiology;place fields;Play;Potassium Channel;Procedures;Pyramidal Cells;Role;Sensory;Sodium;Source Code;subcellular targeting;Synapses;System;Techniques;tool;Visual

PROJECT_TITLE: CRCNS: Understanding Single-Neuron Computation Using Nonlinear Model Optimization


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_NAME: RHODE ISLAND HOSPITAL

PHR: Public Health Relevance Statement In response to the worst overdose crisis in US history and calls for a more effective police response to behavioral health problems, the growing practice of diverting people with opioid use disorder to treatment instead of arrest can improve the health outcomes of police encounters with people who use drugs. To better understand the processes that lead to a police officer’s decision to divert a person to treatment, this project will 1) develop and validate an instrument to measure police stigma toward people who use drugs, 2) use the Theory of Planned Behavior to identify other key variables that determine police officers’ intentions to divert, and 3) determine the officer-perceived barriers and facilitators of effective diversion to treatment. Executing these aims will produce actionable training, policy, and process recommendations for communities seeking to increase connections to evidence-based care for opioid use disorder as a police behavioral health response to the opioid crisis.

PI_NAMEs: DEL POZO, BRANDON  (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Address;Adopted;Affect;Attitude;Award;Behavior;behavior rating scale;Behavioral;behavioral health;Behavioral Sciences;Belief;Caring;Collaborations;Communities;community advisory board;Comprehension;Criminal Justice;Data;data harmonization;design;Diversion Program;Drug user;effective therapy;effectiveness study;effectiveness/implementation study;Equation;Equity;evidence base;expectation;experience;Exploration, Preparation, Implementation, and Sustainment;Focus Groups;Future;Geography;Goals;Health;health equity;Health Priorities;Hospitals;Hybrids;implementation science;implementation study;improved;innovation;instrument;Intervention;Interview;Judgment;Justice;Knowledge;lens;Life;Maps;Measurement;Measures;medication for opioid use disorder;meetings;Mentored Research Scientist Development Award;Mentors;Methods;Modeling;National Institute of Drug Abuse;Opioid;opioid epidemic;opioid mortality;opioid use disorder;organizational readiness;Outcome;Overdose;overdose death;Patient Self-Report;peer support;Persons;Pharmaceutical Preparations;Planning Theory;Police;Police officer;Policies;Positioning Attribute;Postdoctoral Fellow;Principal Component Analysis;Process;programs;Psychometrics;Public Health;public health relevance;Qualitative Methods;Recommendation;Recording of previous events;recruit;Reduce health disparities;Reporting;Research;Research Design;Research Methodology;Research Personnel;response;Sampling;Science;Shapes;social stigma;Strategic Planning;Structure;substance use;Substance Use Disorder;substance use treatment;success;Surveys;synthetic opioid;System;Testing;Text;Time;Training;Translating;treatment services;Trust;United States;Universities

PROJECT_TITLE: Police Diversion to Treatment for Opioid Use Disorder: A Mixed Methods Study

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: FARMINGTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: NARRATIVE  Vertebrate development is the result of a profound and controlled remodeling of gene expression following the fertilization of the egg by the sperm. Interestingly, I have developed new approaches to study the controllers mediating this essential transfer of information. The work in this proposal seeks to discover the regulators and the ways they interact one with each other to generate a fully-grown organism because it will ultimately help to understand human development and disease.

PI_NAMEs: BEAUDOIN, JEAN-DENIS  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Affect;Animals;Automobile Driving;cellular development;Defect;Development;Disease;Embryo;epitranscriptome;Failure;Fertilization;Functional disorder;Gene Expression;Gene Expression Regulation;gene regulatory network;Genetic;Genetic Transcription;Goals;Human Development;human disease;in vivo Model;Inherited;innovation;interest;Investigation;Knowledge;loss of function;Maps;Maternal Messenger RNA;Mediating;Messenger RNA;Modification;Molecular;mRNA Decay;multiple omics;novel strategies;Organism;Post-Transcriptional Regulation;posttranscriptional;Process;programs;Proteins;Regulation;Regulator Genes;RNA;RNA Folding;Role;Shapes;sperm cell;Structure;Testing;transcriptome;Work;Zebrafish;zygote

PROJECT_TITLE: Regulatory roles of the epitranscriptome and RNA structurome during vertebrate development

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Hematology;Orphan Drug;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Narrative Diamond Blackfan Anemia (DBA) is characterized by defective erythropoiesis. Erythroid progenitors from murine and human models of DBA have chronic hyper-activation of Nemo-Like Kinase (NLK), while suppression of NLK improves erythroid expansion in vitro. Understanding the mechanisms by which NLK contributes to disease pathogenesis will potentially lead to novel approaches to treat patients with DBA and other bone marrow failure syndromes.

PI_NAMEs: WILKES, MARK CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Allogenic;analog;Anemia;Autologous Stem Cell Transplantation;Autologous Transplantation;Automobile Driving;Biogenesis;Bioinformatics;Biological Assay;Biology;bone marrow failure syndrome;career;career development;Chronic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;computerized tools;congenital anomaly;congenital bone marrow failure;CRISPR/Cas technology;Data;Dedications;Defect;Development;Diamond-Blackfan anemia;Disease;DNA Sequence Alteration;Engraftment;Erythrocyte Transfusion;Erythroid;Erythropoiesis;Event;Faculty;Fellowship;gene therapy;Genes;genome wide screen;genome-wide analysis;Goals;Graft Rejection;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human;human model;improved;improved outcome;In Vitro;in vitro Model;in vivo;in vivo Model;insight;kinase inhibitor;Knock-out;Long-Term Effects;malformation;Malignant Neoplasms;MAP3K7 gene;Mediating;member;Mentors;Mentorship;Mitochondria;Modeling;mouse model;Mus;Mutation;nemo-like kinase;new therapeutic target;Non-Neoplastic Hematologic and Lymphocytic Disorder;novel;novel strategies;novel therapeutics;Pathogenesis;Pathway interactions;Patients;Personnel Management;pharmacologic;Phosphorylation;Predisposition;Process;Production;progenitor;programs;Proteins;Research;Resolution;response;Retrotransposon;Ribosomes;Risk;RNA;Role;RPS19 gene;S100A8 gene;skill acquisition;skills;Sleeping Beauty;Stem cell transplant;stem cells;Steroids;System;Teacher Professional Development;Technology;Therapeutic;therapeutic target;tool;Toxic effect;Transplantation;Uncertainty;Work

PROJECT_TITLE: Characterization of the Role of Nemo-like Kinase in Normal and Diamond Blackfan Anemia Models of Erythropoiesis.

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Aging;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Nutrition

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PUBLIC HEALTH RELEVANCE: Homeostasis, or stability within the body is important for optimal functioning, however, the loss of the ability to maintain homeostasis and the subsequent effect on ideal swallowing function is not understood. The proposed study will provide an understanding of how the loss of the functional reserves that regulate homeostasis contributes to swallowing impairment in ALS and the frail elderly. This research is relevant to public health since the results will help facilitate the development of biologically informed therapeutics to treat swallowing dysfunction in a variety of patient populations in the future.

PI_NAMEs: LOY, RAELE DONETHA (contact)

PROGRAM_OFFICER_NAME: YUAN, JEAN

PROJECT_TITLE: The Role of Homeostenosis in Bulbar Function in ALS and Aging


ORG_CITY: ALBANY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: PROJECT NARRATIVE DNA nanostructures have promise in biomedical applications such as biosensing, drug delivery and bioimaging, but the field faces several challenges for it to be used in practical applications. In addressing these challenges, I propose to develop robust, multifunctional drug delivery platform for treating multisystemic diseases and design self-assembled 3D DNA crystals as scaffolds for X-ray structure determination using the new technique of Serial Femtosecond X-ray Crystallography. In the long-term, I envision that our modular, platform technology using DNA nanostructures can be adopted by other labs for different disease treatments and drug screening and to obtain crystallographic information of hard-to-crystallize molecules.

PI_NAMEs: CHANDRASEKARAN, ARUN RICHARD  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Antibodies;Area;Award;Binding;Biodistribution;bioimaging;Biological;Biological Availability;Biosensing Techniques;Body System;Cell Culture Techniques;Cells;Chemicals;Crystallization;Crystallography;Data;design;design and construction;Development;Disease;DNA;drug candidate;Drug Carriers;Drug Delivery Systems;Drug Screening;Face;fluorophore;Freezing;Health;Immune response;improved;Ligands;Methods;Minor Groove;Modification;mouse model;Myotonic dystrophy type 1;nanoparticle;Nanostructures;Nanotechnology;National Institute of General Medical Sciences;Oligonucleotides;Peptides;Pharmaceutical Preparations;Polycyclic Compounds;Positioning Attribute;practical application;pre-clinical;Proteins;Radiation induced damage;Research;Research Personnel;Resolution;Roentgen Rays;scaffold;Scaffolding Protein;screening;self assembly;Structure;Systemic disease;technology platform;Toxic effect;Use of New Techniques;Validation;Work;X-Ray Crystallography;x-ray free-electron laser

PROJECT_TITLE: Programmable DNA Nanostructures as Biomedical and Structural Scaffolds

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Genetics

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: NARRATIVE The overlying goal of the research program is to understand how timing of cell activities - patterning, signaling, and movement - is regulated in the Drosophila early embryo as development proceeds. In particular, the proposed experiments will investigate how initiation of zygotic gene expression is controlled; and how this results in the activation of cell signaling, including through FGFs, which is instrumental for the support of cell movements at gastrulation to transform the blastoderm embryo into multiple layers with distinct tissue types. This work has the potential to provide insight into how diverse cellular functions are coordinated to support normal embryonic development in higher animals, as the regulatory mechanisms are likely conserved.

PI_NAMEs: STATHOPOULOS, ANGELIKE  (contact)

PROJECT_TERMS: Actins;Adherens Junction;Animals;Blastoderm;cell motility;Cell Physiology;Cells;Cellular Morphology;Chromatin;combinatorial;Comparative Study;Cytoskeleton;Data;Development;Dominant-Negative Mutation;Dorsal;Drosophila genus;Embryo;Embryonic Development;Enhancers;epithelial to mesenchymal transition;experimental study;Fibroblast Growth Factor;Funding;gastrulation;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Homologous Gene;Hour;Image;in vivo imaging;insight;Ligands;morphogens;Movement;NF-kappa B;Output;Pattern;preimplantation;Process;programs;Regulatory Element;Research;Series;Signal Pathway;Signal Transduction;Signaling Molecule;Supporting Cell;System;Time;Tissues;Transcript;transcription factor;Variant;Work

PROJECT_TITLE: Temporal control of cell patterning, signaling, and movement in early embryos

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE: Recent epidemiological studies show a rapid increase in Alzheimer's Disease (AD) in Hispanics compared to non-Hispanics whites. However, there is limited understanding about AD determinants in Hispanics and the effect of genes by environment interactions. The proposed application aims to determine the influence of genetics and social disparities of health on age at onset, cognitive profiles, and biomarker trajectories in Hispanic populations.

PI_NAMEs: LLIBRE-GUERRA, JORGE JESUS (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Accounting;Address;Admixture;Age;Age of Onset;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;amyloid imaging;apolipoprotein E-4;Area;Argentina;Award;behavioral neurology;Biological Markers;biomarker signature;Brazil;cardiovascular risk factor;career;Caribbean Hispanic;Caribbean region;Central American;Clinical;Clinical Research;Cognitive;cognitive performance;cohort;Colombia;comorbidity;Data;Data Set;Dementia;design;Development;Diagnosis;Disease;disease disparity;disease heterogeneity;Disease Progression;Disparity;Education;effective intervention;Employment;Enrollment;Environment;Environmental Risk Factor;Epidemiology;epidemiology study;Epigenetic Process;ethnic diversity;Ethnic Population;European;familial Alzheimer disease;Frequencies;Functional disorder;Future;gene environment interaction;Genetic;genetic architecture;Genetic Determinism;genetic epidemiology;Genetic Research;Genetic study;genetic variant;Goals;Health and Retirement Study;health disparity;Hispanic;hispanic community;Hispanic Populations;improved;Inflammation;Inherited;Intervention;K-Series Research Career Programs;Knowledge;Latin America;Life course epidemiology;Life Cycle Stages;Life Style;longitudinal analysis;low socioeconomic status;Measures;Mediating;Mentors;Mexico;Molecular Analysis;Molecular Genetics;molecular marker;multimodality;Neurocognitive;neuroimaging;Not Hispanic or Latino;novel;older adult;Onset of illness;Other Genetics;Participant;Pathology;Pathway interactions;Phenotype;Population;Population Heterogeneity;Population Study;Prevalence;prevent;Prevention;Prevention strategy;Prognosis;Qualifying;rate of change;Recording of previous events;Reporting;Research;Research Personnel;Risk;Risk Factors;Role;Scientist;Severity of illness;skills;social;social disparities;social health determinants;Social Sciences;South American;Statistical Methods;Subgroup;Training;Training Programs;Translating;Universities;Vascular Diseases;Washington;Work;β-amyloid burden

PROJECT_TITLE: Understanding Alzheimer disease heterogeneity in Hispanic populations.

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Estrogen;Immunotherapy;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Progesterone is a sex hormone that governs the menstrual cycle, but it also has anti-inflammatory effects on the immune system in the female reproductive tract, and possibly throughout the body. We propose to study how and why progesterone affects the immune system in the whole body. The results of our studies may contribute to women’s health by explaining sex-based and menstrual cycle-related fluctuations in inflammatory disease and susceptibility to infection.

PI_NAMEs: HLADIK, FLORIAN  (contact);LUND, JENNIFER M

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: adaptive immunity;Address;Affect;aged;Antibodies;Antigen-Presenting Cells;Antiinflammatory Effect;Asthma;asthma exacerbation;Autoimmune Diseases;Bar Codes;Blood;Bone Marrow;CCL2 gene;CCL4 gene;Cell Count;Cells;cervicovaginal;chemokine;Chimera organism;Chlamydia trachomatis;Clinic Visits;Clinical;cohort;Color;cytokine;Data;Dendritic Cells;Disease;Estradiol;Estrogen Therapy;Estrogens;Exhibits;experience;experimental study;falls;female reproductive tract;Flow Cytometry;Frequencies;Gastrointestinal tract structure;Genes;Gonadal Steroid Hormones;HIV;Hormones;Human;Immune;immune function;Immune system;Immunity;Immunologic Factors;Immunologic Receptors;Immunologics;Immunosuppression;improved;in vivo;Infection;Inflammatory;Inflammatory Bowel Diseases;intercellular communication;Interferons;Interleukins;knockout gene;Knowledge;Leukocytes;Link;Luteal Phase;Luteinizing Hormone;Macrophage;Measures;Mediating;Membrane Proteins;Menstrual cycle;monocyte;mouse model;Mucous Membrane;Mus;Natural Immunity;Nose;Oligonucleotides;Ovariectomy;Phase;Physiological;Population;Postmenopause;Predisposition;Premature Birth;prevent;primary endpoint;Production;Progesterone;Progesterone Receptors;proliferative phase Menstrual cycle;Property;Receptor Gene;recruit;Rectum;reproductive function;reproductive tract;Resistance to infection;response;Rheumatoid Arthritis;Role;Serum;sex;Signal Transduction;single-cell RNA sequencing;Site;Skin;skin biopsy;stem;Symptoms;Synthetic Progestogens;Testing;tissue resident memory T cell;Tissues;Upper respiratory tract;urinary;Vaccination;Vagina;Visit;Woman;Women's Health

PROJECT_TITLE: The regulatory role of natural progesterone in barrier immunity

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Rural Health;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: Public Health Relevance  The State of Maine faces challenging cancer heath disparities, as it is the most rural and oldest state in the nation. Historically, cancer patients and their families in Maine have had inconsistent access to state-of-the-art federally-sponsored cancer research trials. The MaineHealth Cancer Care Network (MHCCN) Lifespan proposal provides a wonderful opportunity and departure point for our organization to be considered for inclusion in the NCI Community Oncology Program and to provide access for our patients to this vital resource. We value making substantive contributions and providing leadership to NCORP over the next award period.

PI_NAMEs: BRADFORD, LESLIE ;LU-EMERSON, CHRISTINE ;REMICK, SCOT C (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Academic Medical Centers;Adolescent and Young Adult;Adult;anti-cancer research;Arsenic;Award;Cancer Burden;cancer care;Cancer Center;cancer clinical trial;Cancer Control;Cancer Control Research;cancer genomics;cancer health disparity;Cancer Model;Cancer Patient;cancer prevention;cancer risk;care delivery;career development;Caring;Cause of Death;Child;Childhood;cigarette smoking;Clinical;Clinical Research;Clinical Trials;Clinical Trials Network;Communities;Community Care Networks;Community Clinical Oncology Program;community engagement;community setting;Complex;Consensus;Denmark;Diagnosis;early phase trial;Elderly;end of life;Enrollment;Environmental Exposure;Evaluation;Evolution;expectation;Face;Family;Fostering;Genomics;Geography;Goals;Grant;Growth;Health Personnel;Health system;Healthcare;Healthcare Systems;High Prevalence;Home;Hospitals;Human papilloma virus infection;improved;Incidence;Infrastructure;inhibitor;Institution;interdisciplinary approach;Intervention;Investments;Lead;Leadership;life span;Location;Maine;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical;member;metropolitan;Mission;Morbidity - disease rate;mortality;New England;next generation;Obesity;Occupational;Oncology;oncology program;Operative Surgical Procedures;Outcome;Outcomes Research;outpatient facility;Participant;patient oriented;Patient Participation;Patient-Centered Care;Patients;Personal Satisfaction;Population;Prevention;Prevention Research;Process;Productivity;Provider;public health relevance;Quality of life;Radiation;Radon;Reporting;Research;Research Design;Research Personnel;research study;Resources;response;Risk Behaviors;Rural;rural area;rural cancer care;rural setting;screening;socioeconomics;Spain;Specialist;Strategic Planning;Sun Exposure;survivorship;System;Testing;Therapeutic;Time;Translational Research;trial enrollment

PROJECT_TITLE: MaineHealth Cancer Care Network (MHCCN) and NCORP Activities across the Lifespan


ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Dysregulation of the ubiquitin-proteasome system (UPS) has been implicated in many diseases including cancer and neurodegenerative disorders. Advancing XL- MS technologies to define in vivo interaction landscape and structural dynamics of proteomes at the systems-level will enable detailed delineation of the UPS network to understand its association with human pathologies and uncover potential targets for improved therapeutics.

PI_NAMEs: HUANG, LAN  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;advanced system;Biological;Biological Process;Biology;Cell Physiology;Cells;Clinical;crosslink;Cullin Proteins;Degradation Pathway;Development;Disease;drug discovery;Environment;Eukaryota;Health;Human;human disease;Human Pathology;improved;in vivo;Ligase;Link;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Medicine;Molecular;multicatalytic endopeptidase complex;Neurodegenerative Disorders;novel;Pathway interactions;Physiological;preservation;Proteasome Inhibitor;protein complex;protein degradation;protein protein interaction;Protein-Protein Interaction Map;Proteins;Proteome;Proteomics;Regulation;Research;Resolution;structural biology;success;System;Systems Biology;Technology;Therapeutic;therapeutic development;Ubiquitin;Ubiquitination

PROJECT_TITLE: Advancing Proteomics Technologies to Decipher the Ubiquitin-Proteasome System


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Kidney Disease;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: NARRATIVE Variants in SIX1, a transcription factor implicated in many cellular processes during craniofacial development and in branchio-oto-renal syndrome, have been recently linked to craniosynostosis (premature closure of the sutures between the skull bones); this is one of the most prevalent birth defects affecting ~1:2500 live births. The studies proposed in this NIDCR career development award application will address the major knowledge gap regarding the role of Six1 in calvarial bone development, and provide new knowledge regarding the pathogenesis of this prevalent birth defect, thus facilitating diagnosis and care of craniosynostosis patients.

PI_NAMEs: TAVARES, ANDRE L P (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Address;Adult;Affect;Animal Model;Area;autosome;Birth;bone;Bone Development;Brain Injuries;Branchio-Oto-Renal Syndrome;Calvaria;career;Caring;Cartilage;Cell Differentiation process;Cell Lineage;Cell Physiology;Cells;Cephalic;Clinical Research;clinically relevant;cofactor;Collaborations;Complex;Congenital Abnormality;craniofacial;craniofacial development;Craniosynostosis;cranium;cytochemistry;Data;Defect;Deposition;Development;Diagnosis;Disease;dosage;Dose;Embryo;Embryonic Development;experimental study;Foundations;Frontal bone structure;Funding;Future;Gene Expression;Genetic;Genetic Transcription;Head;hearing impairment;Heterozygote;Histologic;Homeostasis;Human;Image;In Vitro;in vivo;Individual;Intracranial Hypertension;Joint structure of suture of skull;Joints;K-Series Research Career Programs;Kidney;Knowledge;Lead;Left;Legal patent;Link;Live Birth;Maintenance;Mandible;Mesenchymal;Mesenchyme;mineralization;Modeling;Morphogenesis;Morphology;Mus;Muscle;National Institute of Dental and Craniofacial Research;neural;Neural Crest;Osteoblasts;Osteogenesis;osteogenic;osteoprogenitor cell;Parietal bone structure;Pathogenesis;Patients;Pattern;Physiologic Ossification;Population;postnatal;precursor cell;premature;Reporting;Repression;Research;Role;Shapes;single-cell RNA sequencing;skills;Specific qualifier value;Surgical sutures;Testing;Time;Tissues;Training;transcription factor;Transgenic Animals;Variant;Work

PROJECT_TITLE: Dissecting the role of Six1 and its co-factors during calvarial bone and suture development

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


PHR: Pediatric HIV/AIDS & Infection-Related Malignancies Research Consortium for Sub-Saharan Africa (PARCA) This proposal is to establish the Pediatric HIV/AIDS and Infection-Related Malignancies Research Consortium for Sub-Saharan Africa (PARCA), a collaborative clinical and translational research framework with the goal to improve the unacceptably poor outcomes of children with HIV-associated malignancies in SSA.

PI_NAMEs: ALLEN, CARL E (contact);JOLOBA, MOSES LUTAAKOME;LUBEGA, JOSEPH

PROGRAM_OFFICER_NAME: DOMINGUEZ, GERALDINA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescent;Affect;Africa South of the Sahara;African;AIDS related cancer;Biometry;Botswana;cancer care;cancer epidemiology;Cancer Patient;cancer survival;career development;Caring;Child;Childhood;clinical infrastructure;Clinical Research;Collaborations;Complement;Country;Dedications;Descriptive Epidemiology;design;Development;Diagnosis;Diagnostic;Disparity;Education;Epidemic;Fellowship;Fellowship Program;Goals;Healthcare;Hematological Disease;Hematology;HIV;HIV Infections;HIV/AIDS;improved;improved outcome;Incidence;infection related cancer;Infrastructure;International;Kaposi Sarcoma;Laboratories;Lead;Lymphoma;Malawi;Malignant Childhood Neoplasm;Malignant Neoplasms;Modeling;mortality;Oncology;operation;Outcome;patient population;Patient-Focused Outcomes;Patients;Pediatric Hematology;Pediatric Hospitals;pediatric human immunodeficiency virus;Pediatric Oncologist;Pediatric Oncology;Pediatric Oncology Group;pediatric patients;programs;Research;Research Project Grants;Resource-limited setting;Resources;Risk;Risk Factors;risk stratification;Site;success;Texas;Training;training opportunity;Training Programs;Translational Research;Uganda;Work

PROJECT_TITLE: Pediatric HIV/AIDS & Infection-Related Malignancies Research Consortium for sub-Saharan Africa (PARCA)


NIH_SPENDING_CATS: Cancer;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS

PHR: ADMINISTRATIVE CORE (CORE A) – Pediatric HIV/AIDS & Infection-Related Malignancies Research Consortium for Sub-Saharan Africa (PARCA) The PARCA Administrative Core (Core A) will provide administrative support for the individual projects and cores, as well as their integration into the Consortium. This core has overall fiscal and scientific responsibility for the entire Consortium, including employment of key personnel to oversee its efficient operation.

PI_NAMEs: ALLEN, CARL E (contact)

PROJECT_TERMS: Africa South of the Sahara;Annual Reports;Budgets;Communication;cost;Data;design;editorial;Educational Materials;Employment;Ensure;Expenditure;Feedback;HIV/AIDS;Human Resources;Individual;infection related cancer;Institutional Review Boards;instrument;Job Description;Leadership;Manuscripts;meetings;member;Monitor;operation;pediatric human immunodeficiency virus;Preparation;Progress Reports;Protocols documentation;Quality Control;Questionnaires;Reporting;Research;Site;Surveys;Teleconferences;videoconference

PROJECT_TITLE: Administrative Core


ORG_CITY: HANOVER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative The dysregulation of autophagy is associated with cancer, neurodegeneration and aging, but the mechanistic details behind these relationships are poorly understood. The proposed research will elucidate the role of autophagy receptors in selective autophagy, focusing on the mechanism(s) by which receptors identify potentially toxic structures and induce their degradation. A thorough understanding of autophagy induction mechanisms will inform our understanding of how autophagy becomes dysregulated in disease and guide therapeutic attempts to ameliorate these deficiencies.

PI_NAMEs: SHOEMAKER, CHRISTOPHER J (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TITLE: Cargo-responsive mechanisms in autophagy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;HIV/AIDS;Hematology;Infectious Diseases;Pediatric;Pediatric - AIDS;Pediatric Cancer;Rare Diseases

PHR: Pediatric HIV/AIDS & Infection-Related Malignancies Research Consortium for Sub-Saharan Africa (PARCA): Developmental Core (Core B) PROJECT NARRATIVE Multi-disciplinary training and mentoring are critical components to build capacity for pediatric HIV-related cancer research and care. It will be the responsibility of the Developmental Core to establish a cross- institutional training and mentoring program to provide PARCA investigators the training opportunities required to develop their careers in pediatric HIV-related cancers and related disciplines such as pediatric oncology, pathology, and clinical research.

PI_NAMEs: LUBEGA, JOSEPH  (contact)

PROJECT_TERMS: Address;Africa South of the Sahara;anti-cancer research;Area;cancer care;Cancer Center;career;Childhood;Clinical;Clinical Research;Communicable Diseases;Department chair;design;Development;Discipline;Education;Educational Materials;Ethics;Fellowship;Fellowship Program;Goals;HIV/AIDS;Human;infection related cancer;Institution;International;investigator training;Malignant Childhood Neoplasm;Malignant Neoplasms;Mentors;multidisciplinary;Oncology;Participant;Pathology;pediatric department;Pediatric Hematology;pediatric human immunodeficiency virus;Pediatric Oncology;Physician Executives;Pilot Projects;Procedures;professor;programs;Qualifying;recruit;Research;Research Personnel;Science;Textbooks;Training;Training and Education;training opportunity;translational oncology;translational scientist;Universities

PROJECT_TITLE: Developmental Core


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE SGLT2 inhibitors are approved for the treatment of type 2, but not type 1, diabetes patients primarily because of the (i) increased incidence of diabetic ketoacidosis (DKA) in the later group, and (ii) stimulation of endogenous (hepatic) glucose production, thus impairing their glucose lowering effectiveness. A clearer understanding of the pathophysiologic mechanisms responsible for the stimulation of ketogenesis and hepatic glucose production, as well as treatment regimens that can effectively block the SGLT2i-induced stimulation of these two metabolic processes, are needed. In the present grant we will employ innovative study designs in combination with isotopes: (i) to elucidate the mechanisms via which SGLT2 inhibitors stimulate ketone production and hepatic glucose production (HGP), and (ii) to examine whether coadministration of pioglitazone, an antidiabetic agent approved by the FDA, with empagliflozin can prevent the SGLT2i-induced stimulation of ketosis and HGP.

PI_NAMEs: DEFRONZO, RALPH A (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: absorption;Acetoacetates;Adipose tissue;Anti-diabetic Drugs;Applications Grants;Atherosclerosis;Cardiovascular system;Chronic Kidney Failure;Clinical;clinical efficacy;Closure by clamp;Communities;Development;Diabetes Mellitus;diabetic;Diabetic Ketoacidosis;Diabetic Nephropathy;diabetic patient;Effectiveness;euglycemia;Event;Exclusion;Excretory function;FDA approved;Gluconeogenesis;Glucose;Glucose Plasma Concentration;glucose production;Glycerol;Grant;Heart failure;Hepatic;Hepatic Tissue;Hyperglycemia;Impairment;Incidence;Individual;inhibitor;innovation;Insulin-Dependent Diabetes Mellitus;Isotopes;ketogenesis;Ketones;Ketosis;Kidney;Lipolysis;Medical;member;Metabolic;Metabolism;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Norepinephrine;Outcome;Outcome Study;Pancreas;Patients;Pharmaceutical Preparations;Pioglitazone;Plasma;prevent;Production;Propranolol;Protocols documentation;Radioisotopes;Reporting;Research Design;Risk;Role;side effect;Sodium;stable isotope;Treatment Protocols;type I and type II diabetes;uptake;Urine

PROJECT_TITLE: SGLT2 Inhibitors, Ketogenesis, and Ketoacidosis

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Cancer;HIV/AIDS;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric - AIDS

PHR: Pediatric HIV/AIDS & Infection-Related Malignancies Research Consortium for Sub-Saharan Africa (PARCA): Biostatistics & Clinical Research Core (Core C) The responsibilities of the Biostatistics & Clinical Research Core (Core C) include support of the individual projects and other cores, as well as the overall data management for the Consortium as a whole. To accomplish these objectives, Biostatistics & Clinical Research Core will oversee data management, study design, statistical analyses, and quality assurance and regulatory compliance for PARCA research projects.

PI_NAMEs: HILSENBECK, SUSAN G. (contact)

PROJECT_TERMS: Africa South of the Sahara;Biometry;Clinical Research;college;Comprehensive Cancer Center;Computer software;Data;data management;data quality;Data Security;Databases;design;Documentation;Ensure;Ethics;experimental study;Health Sciences;HIV/AIDS;improved;Individual;infection related cancer;Information Retrieval;International;Laboratories;lecturer;Medicine;Monitor;Pathologic;pediatric human immunodeficiency virus;Pilot Projects;professor;Public Health Schools;quality assurance;Reporting;Research;Research Design;Research Project Grants;Resource Sharing;Sample Size;Science;Services;Statistical Data Interpretation;Universities;Update;Work

PROJECT_TITLE: Biostatistics & Clinical Research Core


NIH_SPENDING_CATS: Cancer;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Pediatric;Pediatric - AIDS;Pediatric Cancer;Rare Diseases

PHR: Diagnostic & Laboratory Core (Core D) The responsibilities of the Diagnostic & Laboratory Core (Core D) include support for the processing of all biospecimens generated from the Projects and for implementing improvements in the pediatric cancer diagnosis algorithm at the SSA sites.

PI_NAMEs: GASTIER-FOSTER, JULIE M (contact)

PROJECT_TERMS: accurate diagnosis;Africa;Africa South of the Sahara;Algorithms;B-Cell NonHodgkins Lymphoma;cancer diagnosis;Caring;Characteristics;Chemistry;Clinical;clinical care;clinical diagnosis;clinical diagnostics;Collection;Development;Diagnosis;Diagnostic;diagnostic algorithm;Disease;Education;Ensure;experience;feasibility testing;Flow Cytometry;Funding;Histologic;HIV;HIV/AIDS;Immunohistochemistry;improved;infection related cancer;Kaposi Sarcoma;Laboratories;Laboratory Personnel;large cell Diffuse non-Hodgkin's lymphoma;low and middle-income countries;Malawi;Malignant Childhood Neoplasm;Medicine;Methodology;Pathologist;Pathology;Patient Monitoring;Patients;pediatric human immunodeficiency virus;Preparation;Process;prospective;Protocols documentation;rapid diagnosis;Research;research study;Sampling;Services;Shipping;Site;Standardization;Testing;Training;Uganda;Utilization Review;Validation;virtual

PROJECT_TITLE: Diagnostics & Laboratory Core


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Aggressive chemotherapy cannot be tolerated in the majority of adult AML patients due to advanced age. Novel, non-toxic therapeutic strategies are highly sought after to improve AML survival. We have shown that ascorbate treatment can block AML progression by enhancing the activity of TET enzymes without adverse effects. Our goal is to elucidate the mechanistic role of TET proteins in ascorbate-mediated AML sensitivity, identify rational drug combination treatment strategies using ascorbate as an adjuvant, and optimize the bioavailability of ascorbate to increase its efficacy as a TET cofactor for AML therapy.

PI_NAMEs: CIMMINO, LUISA  (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adjuvant;Adjuvant Therapy;Adult;Adult Acute Myeloblastic Leukemia;Adverse effects;Age Years;Aggressive behavior;Alleles;alternative treatment;analog;Animal Model;Antineoplastic Agents;Antioxidants;aqueous;ascorbate;Ascorbic Acid;Biological Assay;Biological Availability;Bone Marrow Transplantation;cancer cell;Cell Line;Cell model;Chemicals;Chemistry;chemotherapy;clinical translation;cofactor;combinatorial;Combined Modality Therapy;Data;Dedications;demethylation;Dependence;Diagnosis;Disease;DNA;Dose;Drug Combinations;Drug Kinetics;Elderly;Elderly Acute Myeloblastic Leukemia;Enzymes;epigenome;Foundations;Functional dependence;functional restoration;Gene Expression;Gene Silencing;Genetic;Genetic Screening;Goals;Growth;Hematologic Neoplasms;Hematopoietic;Heterozygote;Human;Hypermethylation;Impairment;improved;in vivo;Infusion procedures;Lesion;leukemia;leukemia treatment;Leukemic Cell;Libraries;lipophilicity;Liposomes;loss of function;loss of function mutation;Measures;Mediating;Micronutrients;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Myeloid Cells;novel;novel strategies;Oncogenic;oxidation;patient subsets;Patients;pharmacologic;Physiological;preclinical efficacy;Prognosis;programs;Property;Proteins;rational design;Research;Residual state;Role;screening;self-renewal;Sodium;Surface;synergism;targeted treatment;Testing;Tetanus Helper Peptide;Therapeutic;Therapeutic Agents;therapeutically effective;Treatment Efficacy;Treatment outcome;treatment response;treatment strategy;tumor;Tumor Suppressor Proteins;uptake;Water;Xenograft procedure

PROJECT_TITLE: Enhancing TET activity for the treatment of hematological malignancy

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


NIH_SPENDING_CATS: Burden of Illness;Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Pediatric Cancer;Prevention;Rare Diseases

PHR: Project 1: Epidemiology of and Risk Prediction for Childhood Cancers in the Context of HIV/AIDS in Africa Sub-Saharan Africa (SSA) disproportionately bears the burden of pediatric HIV/AIDS, having approximately 90% of the 1.7 million pediatric cases of HIV. The overall goal of this Project is to determine factors associated with risk of developing malignancy among HIV-infected children in SSA.

PI_NAMEs: SCHEURER, MICHAEL E. (contact)

PROJECT_TERMS: 14 year old;Acquired Immunodeficiency Syndrome;Acute;Address;Adult;Africa;Africa South of the Sahara;AIDS related cancer;antiretroviral therapy;Biological Markers;biomarker identification;Blood;Cancer Burden;cancer diagnosis;cancer epidemiology;cancer risk;Caring;Cells;chemokine;Child;Childhood;Clinic;Clinical;Clinical Data;clinical risk;cohort;Collection;college;comorbidity;cytokine;Data;Diagnosis;Disease;electronic medical record system;Environment;Epidemiology;epidemiology study;experience;Future;Goals;Herpesviridae;high risk;high risk population;HIV;HIV Infections;HIV/AIDS;Human Herpesvirus 4;Human Herpesvirus 8;Immune system;immunodeficiency;Incidence;Infection;infection related cancer;International;Invaded;Kaposi Sarcoma;Laboratories;Life;Literature;Lymphoma;Malignant Childhood Neoplasm;Malignant Neoplasms;Malnutrition;Medicine;novel;Pediatric epidemiology;Pediatric Hospitals;pediatric human immunodeficiency virus;Plasma;Population;Prevalence;Protocols documentation;Recording of previous events;Research;Resources;Risk;Risk Factors;risk prediction;Screening for cancer;Severities;Site;Texas;Time;Update;Viral Load result;Viral Markers;Virus

PROJECT_TITLE: Pediatric HIV and Cancer Epidemiology


NIH_SPENDING_CATS: Cancer;Clinical Research;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Pediatric;Pediatric - AIDS;Pediatric Cancer;Rare Diseases

PHR: Project 2: Improving the Accuracy of Diagnosis of Cancer in Children with HIV Infection The goal of Project 2 is to evaluate and implement novel strategies that are reproducible and sustainable across treatment sites in SSA to improve real-time diagnosis of HIV-associated pediatric cancers, because this is a prerequisite for evidence-based treatment and clinical/translational research.

PROJECT_TERMS: Address;Adult;Africa South of the Sahara;AIDS related cancer;Algorithms;anti-cancer research;Antibodies;Archives;Biological Assay;Biopsy;Botswana;Burkitt Lymphoma;cancer diagnosis;cancer therapy;Chest;Child;Childhood;Clinical;Clinical Pathology;Color;cost;Cytogenetics;Dedications;design;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic algorithm;diagnostic assay;diagnostic biomarker;diagnostic platform;Diagnostic Procedure;diagnostic strategy;Ensure;Evidence based treatment;experience;Fine needle aspiration biopsy;Flow Cytometry;Foundations;Goals;Health Personnel;Hematoxylin and Eosin Staining Method;HIV;HIV diagnosis;HIV Infections;HIV/AIDS;Hospitals;Human Resources;Image;Immunohistochemistry;improved;Incisional Biopsy;Infection;infection related cancer;Infiltration;Infrastructure;Laboratories;Lesion;leukemia/lymphoma;Link;lymph nodes;lymphadenopathy;Lymphoma;Malawi;Malignant Childhood Neoplasm;Malignant Neoplasms;Molecular;molecular diagnostics;Morphology;Needle biopsy procedure;novel;novel diagnostics;novel strategies;Operative Surgical Procedures;Opportunistic Infections;Pathologist;Pathology;pediatric human immunodeficiency virus;Peripheral;Predictive Value;Preparation;Procedures;Process;Protocols documentation;Recording of previous events;recruit;Reporting;Reproducibility;Research;research facility;Sedation procedure;Site;skills;skin lesion;Specificity;Stains;Standardization;success;Superficial Lesion;System;Tanzania;Testing;Time;Tissues;Training;Translational Research;treatment site;tumor;Uganda;ultrasound;United States;virtual


NIH_SPENDING_CATS: Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric - AIDS;Pediatric Cancer;Rare Diseases

PHR: PROJECT 3: Establishing a Platform for Clinical Improvement for Children with HIV-Associated Malignancies in Sub-Saharan Africa Outcomes for children with cancer in sub-Saharan Africa (SSA) are unacceptable, with fewer than 20% of those diagnosed surviving. The overall goal of Project 3 is to establish a standardized multi-site strategy to deliver safe and effective disease-specific and risk-stratified care to children with HIV-associated malignancies in SSA.

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adopted;Adoption;Affect;Africa South of the Sahara;AIDS related cancer;antiretroviral therapy;Awareness;B-Cell NonHodgkins Lymphoma;Biologic Characteristic;Biology;Bone Marrow;Botswana;Caring;Central Africa;Cerebrospinal Fluid;Child;Child Care;Childhood;chronic infection;Clinical;clinical care;clinical center;clinical practice;Clinical Research;Clinical Treatment;Clinical Trials Network;clinically significant;Collaborations;college;comorbidity;Complex;Conduct Clinical Trials;cytokine;Development;Diagnosis;Diagnostic Imaging;Disease;Eastern Africa;Epidemic;Evaluation;Event;evidence base;experience;feasibility testing;Foundations;Frequencies;Future;Goals;Health;Hematology;high risk;HIV;HIV Infections;HIV Seronegativity;HIV/AIDS;Hospitals;Human Herpesvirus 4;Human Herpesvirus 8;Human Resources;implementation barriers;improved;improved outcome;Incidence;infection related cancer;Inferior;Infrastructure;International;Kaposi Sarcoma;Lactate Dehydrogenase;Malawi;Malignant Childhood Neoplasm;Malignant Neoplasms;Malnutrition;Mature B-Lymphocyte;Medicine;Methods;Modeling;multidisciplinary;novel strategies;Outcome;Pathology;Patients;Pediatric Hospitals;pediatric human immunodeficiency virus;Pediatric Oncology;Pediatric Oncology Group;Phenotype;Plasma;Poverty;Prediction of Response to Therapy;programs;Regimen;Research;response;Risk;risk stratification;Site;skills;Staging;Standardization;standardized care;Supportive care;survival outcome;Texas;Toxic effect;Treatment Protocols;treatment strategy;tumor;Tumor Markers;Uganda;United States


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Pancreatic cancer is one of the most lethal malignancies with poor long-term survival due to its delayed onset of symptoms and notorious resistance to existing chemotherapy and radiation. Hence, there is an unmet urgent need for better early diagnosis, screening and treatment methods. Here our project investigates a protein uniquely expressed in pancreatic tumors and released into patient blood, which we will test as a biomarker and therapeutic target.

PI_NAMEs: LEE, NAM Y (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Affect;angiogenesis;Angiogenesis Inhibitors;Apoptotic;Area;Biological Markers;Blood;Blood Vessels;Breast;cancer cell;Cell Culture Techniques;Cell Death;Cell Line;Cell surface;Cell Survival;cell type;Cells;Characteristics;Chemoresistance;Chemotherapy and/or radiation;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Colon;Data;Desmoplastic;Diagnostic;differential expression;Disease;Disease Progression;Disseminated Malignant Neoplasm;Drug Delivery Systems;drug efficacy;Early Diagnosis;Endoglin;Endothelial Cells;Endothelium;experimental study;genome editing;Growth;Impairment;improved;Investigation;Knock-out;Knowledge;KPC model;Link;Lung;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Membrane;Methods;Molecular;mouse model;Mus;Nature;Neoplasm Metastasis;neoplastic cell;Neutralization Tests;novel;Organoids;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic neoplasm;paracrine;Pathway interactions;Patients;Perfusion;Pharmaceutical Preparations;pharmacologic;Prognosis;prognostic;prognostic indicator;Protein Isoforms;Proteins;Proteomics;Reagent;receptor;Reporting;Resistance;RNA Splicing;Role;Sampling;screening;Serum;Signal Transduction;Solid;spatiotemporal;Symptoms;targeted treatment;Testing;Therapeutic;therapeutic target;Transforming Growth Factor beta;treatment response;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Variant;Vascular Endothelial Cell;Vascular remodeling;Vascularization;Work

PROJECT_TITLE: Tumor-intrinsic and paracrine roles of endoglin in pancreatic cancer

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lewy Body Dementia;Microbiome;Neurodegenerative;Neurosciences;Parkinson's Disease;Sleep Research

ORG_CITY: ALBUQUERQUE

ORG_NAME: LOVELACE BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: NM

PHR: PROJECT NARRATIVE Microbiome-gut-brain dysfunction may be one of the earliest disease processes contributing to the development of Lewy body diseases. The current project will evaluate specific aspects of microbiome-gut-brain dysfunction in prodromal and symptomatic patients to identify potential early disease mechanisms. Understanding these factors can inform future treatments targeting gut-brain-dysfunction in Lewy body diseases.

PI_NAMEs: RYMAN, SEPHIRA  (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Accounting;Age;Aging;alpha synuclein;Alzheimer's disease related dementia;Area;Automobile Driving;Bacterial Translocation;Blood specimen;brain dysfunction;Breath Tests;Categories;Cell Nucleus;Central Nervous System;Clinic;Clinical;clinical practice;Clinical Trials;Cross-Sectional Studies;Dementia with Lewy Bodies;Development;Diagnosis;Disease;dysbiosis;effective therapy;Evaluation;Event;Exhibits;Exposure to;follow-up;Functional disorder;Functional impairment;Future;gut bacteria;gut microbiome;Health Sciences;Hydrogen Sulfide;Impaired cognition;Intervention;Intestinal permeability;Knowledge;Lactulose;Leaky Gut;Lewy Body Dementia;Lewy Body Disease;lipopolysaccharide-binding protein;Lipopolysaccharides;locus ceruleus structure;magnetic resonance imaging biomarker;Measurement;Memory;microbial;microbiome;Midbrain structure;motor symptom;Movement Disorders;Nerve Degeneration;Neurobehavioral Manifestations;neuron loss;New Mexico;novel;Outcome;Parkinson Disease;Parkinson's Dementia;pars compacta;Participant;Pathogenesis;Pathogenicity;Pathologic;Patients;Plasma;Population;Prevalence;prion-like;Process;prospective;recruit;REM Sleep Behavior Disorder;Ribosomal RNA;Role;rRNA Genes;sex;Signal Transduction;Sleep;Substantia nigra structure;sulfate reducing bacteria;Symptoms;synucleinopathy;Testing;Universities;Vagus nerve structure

PROJECT_TITLE: Microbiome-gut-brain dysfunction in prodromal and symptomatic Lewy body diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Z(55)]


PHR: Chemical damage to DNA is a major source of replication stress that can induce genome instability and drive the progression of cancer and ageing. This proposal investigates the mechanisms that enable the cellular DNA replication machinery to tolerate and repair DNA damage. Insights generated by this work may therefore inform the development of interventions that modulate replication stress to treat cancer and genetic diseases.

PI_NAMEs: SEMLOW, DANIEL  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Aging;Bacteria;Biochemical;Biochemistry;Bone marrow failure;Bypass;cancer cell;cancer predisposition;CDC45L gene;Cell Physiology;Cells;Cellular biology;Chemical Agents;Chemical Structure;Chemicals;chemotherapy;Chromatin;Chromosomal Rearrangement;chromosome missegregation;Cisplatin;clinically relevant;Coupled;crosslink;Data;Deoxyribonucleases;Disease Progression;Disparate;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA glycosylase;DNA Interstrand Cross-Link Repair;DNA Interstrand Crosslinking;DNA lesion;DNA Repair;DNA Repair Disorder;DNA replication fork;DNA-protein crosslink;egg;Ensure;Environment;Event;Exhibits;experimental study;Exposure to;Fanconi Anemia pathway;Fanconi's Anemia;flexibility;gene product;Genetic Diseases;Genome;Genome Stability;genome-wide;Genomic Instability;genomic locus;gut bacteria;helicase;homologous recombination;Human;Human Genome;Induced Mutation;Inflammatory;insight;interest;Lesion;Link;Malignant Neoplasms;Maps;MCM2 gene;Mechlorethamine;Metabolism;Methods;microbiome;Molecular;Molecular Biology;Mutagens;Mutation;Natural regeneration;NEIL3 gene;novel;nuclease;Nucleotides;Outcome;Pathway interactions;Peptide Hydrolases;physical property;Physiological;preference;prevent;Process;programs;Proteins;Rana;recruit;repaired;replication stress;Resolution;response;Role;S phase;Shapes;Single-Stranded DNA;Site;Source;Structure;Surgical incisions;Symptoms;Syndrome;Therapeutic;Therapeutic Intervention;therapy development;Time;Toxin;tumor progression;Work;Xenopus

PROJECT_TITLE: Emerging Mechanisms of Replication-coupled DNA Repair

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]