NIH_SPENDING_CATS: Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Kidney Disease;Racial and Ethnic Minority Health Research;Regenerative Medicine

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative - Shayna T. J. Bradford, Ph.D. Kidney disease is a global health concern that disproportionately impacts Americans of African descent. Current therapeutics to manage end-stage renal disease, the most severe form of kidney disease, include renal replacement therapies, which are costly or have significant wait times to obtain. Findings from this research will enhance our fundamental knowledge of novel cellular and molecular mediators involved in the acute kidney injury to chronic kidney disease transition, which could be targeted therapeutically to lessen the burden of kidney disease, especially in the vulnerable African American community.

PI_NAMEs: BRADFORD, SHAYNA TOYAN JOY (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Ablation;Acceleration;Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Adopted;Advisory Committees;African American;African American population;African ancestry;Age;American;Area;Award;Biology;Biomedical Research;career;career development;Cell Differentiation process;Cell Line;Cells;Cellular biology;Chronic Kidney Failure;Communities;cost;Data;design;Development Plans;Diabetes Mellitus;diabetic;Disease;Disease Outcome;Disparity;Doctor of Philosophy;Down-Regulation;End stage renal failure;epigenome;epigenomics;Epithelial Cells;equity, diversity, and inclusion;European;Event;experience;Faculty;Fibrosis;Foundations;Genes;Genetic;global health;Goals;Health;health determinants;health disparity;HNF4A gene;Human;Hypertension;hypertensive;improved;In Vitro;in vivo Model;Inflammation;Inflammatory;Inflammatory Response;Injury;injury and repair;Injury to Kidney;innovation;Interferon Type I;Kidney;Kidney Diseases;kidney repair;knockout animal;Knowledge;LoxP-flanked allele;MAP4K4 gene;Mediator;Molecular;Molecular Profiling;mouse model;multiple omics;Mus;Natural regeneration;Nephrons;novel;novel therapeutic intervention;novel therapeutics;organic acid;Persons;Phase;Phenotype;Phosphotransferases;Physicians;Population;Prevalence;Proximal Kidney Tubules;Renal Replacement Therapy;Renal Tissue;Renal tubule structure;repaired;Reporting;Research;Resources;response;Risk Factors;RNA Interference;Role;Scientist;Serine;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;skills;targeted treatment;Technology;Therapeutic;Threonine;Tissue Harvesting;Training;transcriptome;transcriptome sequencing;transcriptomics;Universities;Wait Time;Washington;Work

PROJECT_TITLE: Defining The Role of Failed-Repair Proximal Tubule Cells in AdvancedRenal Disease in African Americans

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biomedical Imaging;Chronic Pain;Hematology;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANESTHESIOLOGY

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Poor recovery from orthopaedic injury, including severe pain and impaired bone healing, affects millions of Americans. Myeloid-lineage cells (peripheral macrophages and spinal cord microglia) are mobilized to resolve tissue damage, however, persistent activation of these cells can be detrimental by contributing to pain and delayed healing. This work aims to develop approaches to monitor dysfunctional myeloid-lineage cells and modulate specific targets for novel therapeutics that will improve post-injury recovery.

PI_NAMEs: TAWFIK, VIVIANNE L (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute Pain;Affect;Affective;American;attenuation;bone fracture repair;bone healing;bone imaging;Cell Lineage;Cells;cellular targeting;chronic pain;Clinical;Complex;critical period;cytokine;Etiology;Functional disorder;Functional impairment;genetic manipulation;glial activation;healing;Human;immune activation;Immune system;Impaired healing;Impairment;improved;improved outcome;in vivo monitoring;Individual;Infiltration;Injury;injury recovery;Innate Immune Response;Intervention;Knowledge;Ligands;Link;Long term disability;Macrophage;Microglia;Molecular;Molecular Profiling;Molecular Target;Monitor;Motivation;mouse model;Myelogenous;new therapeutic target;novel marker;Operative Surgical Procedures;Orthopedics;Pain;Perioperative;Peripheral;Persistent pain;Persons;Positioning Attribute;Positron-Emission Tomography;Recovery;Research;response;response to injury;Risk;serial imaging;Spinal Cord;Surgical Injuries;Tissues;Transgenic Organisms;Trauma;Traumatic injury;Whole Organism;Work;Yolk Sac

PROJECT_TITLE: Myeloid lineage targeting to improve recovery from injury and surgery: Cellular and molecular mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Forty-percent of lymphoma patients relapse and face poor prognosis highlighting the inefficiency of current treatment options and the demand for targeted therapies. BAF-complex genes are one of the most mutated in cancer, with 20% of cases overall and 23% in lymphoma, yet, the mechanism by which BAF promotes malignant transformation is poorly understood. This proposal aims to decipher the biological role of BAF in the initiation, propagation and clonal evolution of lymphoma through effects on chromatin structure.

PI_NAMEs: BARISIC, DARKO  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Address;Affect;Antibodies;Architecture;B cell differentiation;B Cell Proliferation;B-Cell Activation;B-Lymphocytes;Binding;Biological;Biological Assay;cancer type;Cell Physiology;Cells;Cellular biology;cellular engineering;Chromatin;Chromatin Remodeling Factor;Chromatin Structure;Classification;Clonal Evolution;cohesin;Complex;Computer Models;Data;DNA;DNA Damage;Ensure;Epigenetic Process;Event;Face;fluidity;Genes;Genetic Transcription;Genome;genome-wide;Genomic approach;Genomics;Humoral Immunities;Immune response;Immunity;Immunoglobulin Genes;insight;Knockout Mice;large cell Diffuse non-Hodgkin's lymphoma;Link;Lymphoma;Lymphoma cell;Lymphomagenesis;Malignant - descriptor;Malignant Neoplasms;Maps;Mediating;Methods;Modeling;Molecular Conformation;mouse model;mutant mouse model;Mutate;Mutation;new therapeutic target;Normal Cell;novel;Nuclear;Nucleosomes;Pathway interactions;Patients;permissiveness;Play;Polycomb;population based;Positioning Attribute;prevent;Prognosis;programs;Proliferating;Proteins;Publishing;Reaction;Regulation;relapse patients;Repression;Role;single molecule;Slide;Somatic Mutation;stemness;Structure;Structure of germinal center of lymph node;Systems Biology;targeted treatment;Testing;Tissues;transcription factor;Transcriptional Regulation;transcriptome;tumor;Tumor Suppression;tumorigenic

PROJECT_TITLE: Role of chromatin remodeling complex BAF in immunity and lymphoma


ADMINISTERING_IC: MH

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_NAME: COLLIGA APPS CORP.

ORG_STATE: TX

PHR: PROJECT NARRATIVE Mental health problems in childhood are highly prevalent and impairing, placing an immense social and economic burden on society. Parent-child relationships in the early years of life play a critical role in promoting child mental health, with critical and coercive relationships increasing the risk of mental health problems across the lifespan. Our project includes the creation and systematic evaluation of an innovative technology-based therapy system that employs artificial intelligence to monitor and responsively administer dynamic (i.e., as needed) supports to families in real-world settings in order to promote positive family relationships and improve child mental health.

PI_NAMEs: AHLE, MATTHEW WILLIAM (contact);COMER, JONATHAN S;TIMMONS, ADELA

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: adaptive intervention;Address;Adult;Age;Aggressive behavior;Algorithms;analytical method;Anxiety;Appointment;Area;Artificial Intelligence;barrier to care;Behavior;Behavioral;Businesses;Caregivers;Cellular Phone;Cessation of life;Child;Child Mental Health;Child Rearing;Childhood;comparison control;Computer software;Conflict (Psychology);contagion;cost effective;Couples;Data;Data Analytics;data sharing;design;Development;digital solutions;Distal;early childhood;Early Intervention;Economic Burden;Ecosystem;Educational Curriculum;Effectiveness;efficacy evaluation;efficacy testing;Emotions;Engineering;Evaluation;Event;Exposure to;Family;Family Relationship;family support;flexibility;foster child;Fostering;Goals;handheld mobile device;health care availability;Health Services Accessibility;Heart Diseases;Home visitation;Hour;Impairment;improved;in vivo monitoring;Individual;innovation;innovative technologies;interdisciplinary collaboration;Internet;Intervention;invention;Learning;Life;life span;Link;Machine Learning;machine learning algorithm;machine learning method;machine learning prediction algorithm;Malignant Neoplasms;Measurement;Measures;Mediating;Mental Depression;Mental Health;Mental Health Services;Methods;mobile computing;mobile sensing;Modality;Modeling;Monitor;Moods;National Institute of Mental Health;new technology;Outcome;Parent-Child Relations;parenting intervention;Pattern;Performance;Persons;Phase;physical conditioning;Play;Population;Populations at Risk;prevent;preventive intervention;Process;programs;protective effect;psychologic;Psychologist;Psychology;Public Health;randomized, clinical trials;Reporting;Research;research and development;Resources;response;Risk;Role;Safety;Sampling;Schools;Scientific Advances and Accomplishments;service delivery;Service delivery model;social;Societies;Stress;substance use;symptomatic improvement;Symptoms;System;Technology;technology development;technology intervention;technology platform;Testing;Therapeutic;therapeutic effectiveness;Time;Training and Education;treatment response;Underserved Population;wearable device;Work

PROJECT_TITLE: The Development and Systematic Evaluation of an AI-Assisted Just-in-Time-Adaptive-Intervention for Improving Child Mental Health


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Heart Disease - Coronary Heart Disease;Kidney Disease;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Many patients with chronic kidney disease develop heart failure, but the underlying causes remain unclear. Animal models of human disease suggest that the inflammasome may contribute to the development of heart failure in patients with chronic kidney disease. An epidemiologic study and a clinical trial will be conducted to improve our understanding of the role of inflammasome activity in the development of heart failure among adults with chronic kidney disease.

PI_NAMEs: BUCKLEY, LEO FRANCIS (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Ablation;Acute myocardial infarction;Adult;anakinra;Animal Model;Anti-Inflammatory Agents;Area;Atherosclerosis;Atherosclerosis Risk in Communities;Award;C-reactive protein;Cardiac;cardiovascular pharmacology;Cardiovascular system;career;CASP1 gene;Chronic Kidney Failure;Clinical;clinical trial participant;Clinical Trials;Colchicine;Complex;Coronary Arteriosclerosis;Cross-Over Trials;cytokine;Data Analyses;Dedications;design;Development;Doctor of Pharmacy;Double-Blind Method;Echocardiography;Environment;Epidemiology;epidemiology study;exercise capacity;flexibility;Fostering;Functional disorder;Goals;Heart failure;heart failure with reduced ejection fraction;Hospitalization;Host Defense;Human;human disease;human model;human monoclonal antibodies;IL18 gene;Immunology;Impairment;improved;indexing;Inflammasome;Inflammation Mediators;Inflammatory;inhibitor;interest;Interleukin-1;Interleukin-1 beta;Interleukins;Investigation;Kidney;Knowledge;Left;Left Ventricular Dysfunction;Left Ventricular Remodeling;Mediating;Mediator;Mentors;Mentorship;Methodology;Modeling;Modification;Molecular;monocyte;Myocardial;Myocardial Infarction;Myocarditis;older adult;overexpression;Participant;Pathogenesis;Pathway interactions;patient oriented;patient oriented research;Patients;Peptide Hydrolases;pharmacologic;Pharmacotherapy;Placebo Control;Placebos;Plasma;Play;preservation;prevent;primary endpoint;Principal Investigator;Production;programs;Proteins;Randomized;Recombinants;Research;Research Personnel;Risk;Risk Factors;Role;Series;Structure;systemic inflammatory response;Systolic heart failure;Testing;Training;trend;uremic cardiomyopathy;Ventricular;Wild Type Mouse

PROJECT_TITLE: Inflammasome Activity as a Potential Contributor to Uremic Cardiomyopathy

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: LINCOLN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE Fe-S proteins play a central role in redox control and stress response, which is crucial for human health and the survival of bacterial pathogens during infection. Our structural and mechanistic investigations of Fe-S proteins involved in redox sensing and regulation will be instrumental in the understanding of disease progression and the design of new therapeutic strategies against diverse pathogens.

PI_NAMEs: ZHANG, LIMEI  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Address;Anabolism;Bacterial Infections;Binding;Binding Proteins;Biochemical;biological adaptation to stress;Biological Process;Cell Physiology;Cell Survival;cofactor;Communicable Diseases;design;Diabetes Mellitus;Disease;Disease Progression;DNA Repair;experience;Family;Genetic Transcription;Genus Mycobacterium;Goals;Health;Hemostatic function;Homeostasis;Human;improved;In Vitro;in vivo;Infection;Investigation;Iron;Iron-Sulfur Proteins;Life;Ligands;Link;Maintenance;Malignant Neoplasms;Mediating;Metals;Molecular;Molecular Biology;Molecular Weight;monomer;Mycobacterium tuberculosis;novel;novel therapeutic intervention;Oxidation-Reduction;Oxidative Stress;Oxygen;pathogen;pathogenic bacteria;Physiological;Play;programs;Proteins;Regulation;repaired;Research;response;RNA metabolism;Role;skills;Stress;Structural Biochemistry;Structure;Sulfhydryl Compounds;Sulfur;System;transcription factor;Transcriptional Regulation

PROJECT_TITLE: Structures and Mechanisms of Iron-Sulfur Proteins in Redox Control and Stress Response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: RICHMOND

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Narrative Millions of people worldwide receive bone-dwelling biomaterials each year to replace lost or damaged orthopaedic or dental tissues, but long-term implant survival rates are lower in patients who may have impaired wound healing. The aim of this study is to evaluate how physicochemical cues of biomaterials and injury caused by the surgical implantation procedure affect the activity of macrophages, key regulators of the host response to implanted materials. This will allow us to identify key signaling molecules in the local environment that can be targeted to control the inflammatory process and accelerate bone healing in these challenging cases.

PI_NAMEs: OLIVARES-NAVARRETE, RENE  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Ablation;Acceleration;Adoptive Transfer;Adsorption;Affect;Anti-Inflammatory Agents;Area;Behavior;beta catenin;Biocompatible Materials;bone;bone healing;Cell Differentiation process;cell regeneration;Cells;Characteristics;Chemistry;chronic inflammatory disease;Clinical;clinically relevant;Cre-LoxP;CRISPR-mediated transcriptional activation;Cues;cytokine;Cytokine Receptors;Dental;Development;Environment;Event;Failure;gain of function;Goals;Growth Factor;healing;Homeostasis;Immune;Immune response;Impaired wound healing;Implant;implant material;implantation;Implantation procedure;improved;In Vitro;in vivo;Inflammatory;inflammatory milieu;Inflammatory Response;inhibitor;Injury;innovation;insight;Integrins;knockout gene;Knockout Mice;Ligands;Macrophage;Macrophage Activation;Malignant Neoplasms;Mediating;Membrane;Mesenchymal Stem Cells;Modification;Molecular;mouse model;Mus;Natural regeneration;Neoplasms;novel;Operative Surgical Procedures;Orthopedics;Osteoblasts;Osteogenesis;Outcome;Pathway interactions;Patients;Pattern;Persons;pharmacologic;Phenotype;polarized cell;Process;Property;Protein Secretion;Proteins;Receptor Signaling;recruit;Regulation;response;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Source;stem cell differentiation;stem cell proliferation;stem cell self renewal;stem cells;Surface;Surface Properties;Survival Rate;T-Cell Activation;T-Lymphocyte;Testing;tissue regeneration;Tissues;Toll-like receptors;Transgenic Mice;Transgenic Organisms;Translating;Trauma;Wettability;Wnt proteins;WNT Signaling Pathway;Work

PROJECT_TITLE: Role of Wnt Signaling in Macrophage Response to Biomaterials


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE Abnormalities in the calvaria (upper part of the skull) are a major class of birth defects in humans. The proposed project will provide detailed information on the genetic regulation underpinning development of the suture mesenchyme cells, a crucial component of the calvaria. The knowledge gained from this project can help devise new methods for diagnosis, treatment, and prevention of birth defects affecting the calvaria.

PI_NAMEs: JEONG, JUHEE  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Affect;Age;Apical;Appearance;Arachnoid mater;bone;Bone plates;Brain;Calvaria;Cell Differentiation process;cell fate specification;cell type;Cells;Cephalic;Child;Congenital Abnormality;Craniosynostosis;cranium;Data;Defect;Dermis;Development;Diagnosis;differentiation in vitro;Dura Mater;EGFR gene;Embryo;Embryonic Development;Equilibrium;ErbB4 gene;Eye;Foundations;Frontal bone structure;Genes;Genetic;Genetic Markers;Genetic Transcription;Goals;Head;Heterotopic Ossification;Homeobox;Human;human embryonic stem cell;improved;in silico;In Vitro;in vivo;Intervention;Joints;knock-down;Knowledge;Ligands;Meningeal;Meninges;Mesenchyme;Mesoderm;Methods;migration;Molecular Genetics;Mus;mutant;Mutant Strains Mice;Neural Crest Cell;neural model;Operative Surgical Procedures;orofacial development;Osteoblasts;Osteogenesis;osteogenic;overexpression;Parietal bone structure;Pattern;Phenotype;Phosphotransferases;Physiologic Ossification;Play;Population;Pregnancy;premature;prevent;Prevention;progenitor;Public Health;receptor expression;Regenerative Medicine;Regulation;Reporter;Research;Role;Scalp structure;Side;Signal Pathway;Signal Transduction;single cell sequencing;soft tissue;Specific qualifier value;stem cell differentiation;stem cell fate specification;stem cell population;stem cells;Subcutaneous Tissue;Surgical sutures;transcription factor

PROJECT_TITLE: Genetic regulation of embryonic head mesenchyme patterning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-M(02)M]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Pathogenic biofilms are surface-attached microbial communities that significantly affect overall and oral health posing challenges to clinical procedures. This project will help us understand how the action of chewing over dental biomaterials influences microbes adhesion, biofilm formation and pathogenesis, and its role on the progression of oral infectious diseases.

PI_NAMEs: ORREGO, SANTIAGO  (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Affect;Age;Animal Model;Animals;Antifungal Therapy;Area;Bacterial Adhesins;Biocompatible Materials;Biological;Biological Process;Biomass;Biomechanics;Candida albicans;Cell Survival;Charge;Chemistry;Clinical;Communicable Diseases;Communities;Complex;cost;Critical Illness;Dangerousness;density;Dental;Dental caries;Dental Materials;Denture Bases;Denture Stomatitis;Dentures;Development;Diet;Disease;dysbiosis;Etiology;Evaluation;Failure;Family suidae;fungus;Future;Goals;Hard Palate;Health;Healthcare Systems;Histologic;HIV;Human;Hyphae;Immunocompromised Host;Implant;in vitro Model;in vivo;in vivo Model;Infection;Infiltration;Inflammatory;innovation;Knock-out;Knowledge;Malignant Neoplasms;Mastication;Mechanical Stress;mechanotransduction;Medical Device;medical implant;Metabolic;method development;Microbe;microbial;Microbial Biofilms;microbial community;microbiome;microbiota;microbiota composition;Modeling;Molecular;Morphology;Movement;Mucous Membrane;Mycoses;Nutritional;Nylons;older patient;Oral;oral biofilm;Oral cavity;Oral health;oral infection;Oral mucous membrane structure;Pathogenesis;Pathogenicity;Pathway interactions;Penetration;Periodicity;Persons;Pharmaceutical Preparations;Plant Resins;Polymethyl Methacrylate;polymicrobial biofilm;prevent;Prevention;Procedures;Process;Production;Publications;Rattus;Recurrence;Resistance;restorative treatment;Role;Shapes;Signal Transduction;Stress;Surface;Surface Properties;Testing;Time;Treatment Cost;Tuberculosis;Virulence;Virulence Factors;virulence gene;Wettability;Work;Xerostomia;Yeasts

PROJECT_TITLE: Pathogenesis of oral microbes triggered by the cyclic deformation of biomaterials

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative We have developed a method to psychophysically measure nociceptive sensitivity as a separate entity from pain sensitivity. Nociceptive sensitivity will be measured in patients with temporomandibular disorder, some of whom have nociplastic pain features. We will compare their nociceptive and pain sensitivity with data from pain-free controls, which may constitute a novel biomarker for use in other mechanistic studies and clinical trials and give insight into the mechanisms underlying pain hypersensitivity in patients with nociplastic pain.

PI_NAMEs: HARPER, DANIEL ELLIOTT (contact)

PROGRAM_OFFICER_NAME: GRISIUS, MARGARET

PROJECT_TERMS: Absence of pain sensation;Area;Brain;Categories;central pain;central sensitization;chronic pain;chronic painful condition;Clinical;clinical biomarkers;clinical pain;clinical research site;Clinical Treatment;Clinical Trials;cohort;conditioned pain modulation;Data;Descriptor;Detection;Development;effective therapy;Enrollment;experience;Fiber;Fibromyalgia;Forearm;Fright;functional status;Heating;Hyperalgesia;Hypersensitivity;Impairment;Individual;insight;International;Judgment;Knowledge;Masticatory muscles;Measurement;Measures;Methods;Modality;multimodality;Nervous System;Nervous System Trauma;Neuropathy;Nociception;Nociceptors;novel;novel marker;Pain;Pain Free;Pain intensity;Pain Measurement;pain perception;pain processing;pain sensitivity;painful neuropathy;Participant;Pathology;Patients;Peripheral;Persistent pain;Persons;Probability;Procedures;Process;Protocols documentation;Psychophysics;Questionnaires;response;Sensory;Signal Transduction;Skin;somatosensory;sound;Spinal Cord;spontaneous pain;Standardization;Stimulus;success;Techniques;Temperature;Temporomandibular Joint Disorders;Testing;therapeutic target;TMD treatment

PROJECT_TITLE: Nociplastic mechanisms in temporomandibular disorders: Separating nociception from pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Osteonecrosis of the jaw (ONJ), characterized by persistent and painful exposed bone, is a devastating outcome that can occur in patients taking anti-resorptive drugs, and is most common amongst cancer patients taking high doses of these drugs, who harbor a ~5% risk of developing ONJ. Here we integrate cellular, molecular, and pharmacogenomic approaches to characterize the development of ONJ, and identify genetic risk factors for developing this condition.

PI_NAMEs: SURFACE, LAUREN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Affect;Alveolar;alveolar bone;Antibodies;Automobile Driving;biomarker identification;bisphosphonate;bone;bone cell;Bone Diseases;Bone necrosis;Cancer Patient;Cell Separation;cell type;Cells;cellular targeting;chronic pain;Clinical Research;clinically relevant;Code;conditional knockout;CRISPR screen;Cytosol;Dangerousness;Data;Development;Disease;DNA;Dose;Drug Prescriptions;Drug usage;Effector Cell;Fright;Functional disorder;Funding;Genes;Genetic;Genetic Markers;Genetic Predisposition to Disease;genetic risk factor;Genetic Transcription;genome wide association study;genome-wide;genomic locus;Genomics;Genotype;Germ Lines;Goals;high risk;Histology;Immune;in vivo;insight;Investigation;Jaw;Knockout Mice;Knowledge;Label;lysosomal proteins;Macrophage;Mandible;maxillofacial;Mediating;Metastatic Neoplasm to the Bone;Modeling;Molecular;Motivation;mouse model;Multiple Myeloma;Necrosis;novel;Oncology;Oral cavity;Osteoclasts;osteogenic;Osteomyelitis;Osteoporosis;Outcome;Pain;Pathology;patient oriented;Patient risk;Patients;Persons;Pharmaceutical Preparations;Pharmacogenomics;Play;polygenic risk score;precision medicine;predictive marker;Predisposition;Prevention;Proteins;response;Risk;Risk Reduction;risk stratification;RNA;Role;screening;Screening procedure;Signal Pathway;Southwest Oncology Group;Symptoms;tool;trafficking;TRANCE protein;transcriptome sequencing;treatment strategy;uptake;Variant;Work

PROJECT_TITLE: Deciphering Cellular and Genetic Features that Give Rise to Osteonecrosis of the Jaw

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Clinical Research;Data Science;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Narrative The utility of EHRs as a resource for Big Data analytics to generate meaningful insights for understanding disease and improving quality of care is currently limited due to non-random data missingness. In this project, we seek to reduce data missingness and disparity in missingness by leveraging breakthroughs in Large Language Models, and AI-enabled statistical approaches. We will then evaluate the impact of improved data completeness on our understanding of the drivers of periodontal health and disease.

PI_NAMEs: TOKEDE, OLUWABUNMI  (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Address;Adoption;Ally;Behavioral;Big Data Methods;burden of illness;care providers;Caring;Classification;Clinical;clinical care;Clinical Data;clinical decision-making;clinically relevant;Collection;Consumption;cost;Data;data repository;Data Science;Databases;deep learning;Dental;Dental Care;Dental caries;Dental Clinics;dental structure;Dentistry;design;Diagnosis;digital;Disease;Disparity;disparity reduction;Documentation;Ecosystem;Electronic Health Record;electronic structure;Electronics;Ensure;Equity;Evaluation;Event;evidence base;expectation;Health;Health behavior;Health Care Costs;health care delivery;health care service utilization;health data;health disparity;health information technology;Health Personnel;Health system;Healthcare;improved;innovation;insight;Institution;Laboratories;large language model;Learning;Machine Learning;Manuals;Measures;Medical;Medicine;Modeling;multidisciplinary;Natural Language Processing;neural network architecture;novel;operation;optimal treatments;Oral;Outcome;outcome prediction;Paper;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Performance;Periodontal Diseases;Periodontal Index;person centered;Pharmaceutical Preparations;point of care;Population;Positioning Attribute;Prevalence;Prognostic Factor;Quality of Care;Readability;Records;repository;Research;Research Personnel;Resources;Risk;Risk Factors;routine care;Schedule;secondary analysis;Secondary to;Site;Standardization;Structure;structured data;System;Techniques;Technology;Text;Time;Tooth Loss;treatment planning;United States;unstructured clinical data;unstructured data;Update;user-friendly;Vision;Work;Workload;Writing

PROJECT_TITLE: FullMouth: Enhancing Dental Clinical Data and Reducing Disparities through Innovative ML Approaches.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-N(90)S]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Despite recent advances using pharmacotherapy that greatly expanded treatment options for diabetic retinopathy, the cure for this blinding complication is not yet achieved. We have previously demonstrated that ASM is highly upregulated and ELOVL4 is downregulated in the diabetic retina resulting in the shift in the dial of ceramide rheostat from protective, pro-barrier very long chain ceramides (C≥26) to pro-inflammatory and pro- apoptotic short chain ceramides (C≤24). This proposal will test therapeutic potential of increasing ELOVL4 and very long chain ceramides to preserve blood retinal barrier in diabetes.

PI_NAMEs: BUSIK, JULIA V (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: acid sphingomyelinase;Acylation;Animal Model;Apoptosis;Apoptotic;bevacizumab;Binding;Blood Preservation;Blood Vessels;Blood-Retinal Barrier;Cell Culture Techniques;Cells;Ceramides;Clinical Research;combat;Complex;Complication;Complications of Diabetes Mellitus;CYP1A2 gene;Cytochrome P450;Diabetes Mellitus;diabetic;Diabetic Retinopathy;dihydroceramide desaturase;Disease;Down-Regulation;Dyslipidemias;Endothelium;Environment;Enzymes;Equilibrium;Exhibits;Family;Health;Hydroxylation;Immunotherapy;improved outcome;Inflammation;Inflammatory;Length;Linoleic Acids;macular edema;Mediating;Metabolic;Metabolism;neovascular;novel;Pathogenesis;Patients;Permeability;pharmacologic;Pharmacotherapy;Phospholipase;preservation;prevent;Production;protective effect;Proteins;Regulatory Pathway;Retina;retinal damage;Role;Saturated Fatty Acids;Specificity;Sphingolipids;Sphingomyelins;Structure;Symptoms;Testing;therapeutic evaluation;therapeutic target;therapeutically effective;Tight Junctions;Time;Tissues;Transacylase;Up-Regulation;Very Long Chain Fatty Acid;Volatile Fatty Acids;Withdrawal

PROJECT_TITLE: Dyslipidemia and Diabetic Retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Sleep Research;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE One of the consequences of opioid use disorder (OUD) is a disruption of the daily patterns of sleep and stress. Medication-assisted treatments such as methadone and extended-release naltrexone are the front-line treatment for moderate to severe OUD, however there is little understanding of how persistent disruptions of the daily patterns of sleep and stress might impact patients on these medications. This study will use a dual- orexin receptor antagonist to better understand the role of the orexin system in daily patterns of sleep and stress, and whether improving sleep and reducing stress also improves OUD treatment outcomes for persons utilizing methadone or extended-release naltrexone.

PI_NAMEs: FINAN, PATRICK ;HUHN, ANDREW S (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: actigraphy;Affect;Agonist;Ambulatory Monitoring;antagonist;Autopsy;Behavior;behavioral pharmacology;circadian;Circadian Rhythms;clinical practice;Communities;Controlled Study;craving;Data;diaries;Dose;Double-Blind Method;double-blind placebo controlled trial;drug craving;Drug Screening;drug seeking behavior;Ecological momentary assessment;Electronics;Environment;experience;FDA approved;Hormones;Human;human study;Hydrocortisone;hypocretin;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;illicit opioid;improved;improvement on sleep;Individual;Lateral;Literature;long term recovery;Measurement;Measures;Medical;medication-assisted treatment;meetings;Methadone;mu opioid receptors;multimodality;Naltrexone;Neurons;Neurotransmitters;novel;Opioid;Opioid agonist;opioid epidemic;opioid use disorder;Oral;Participant;Patient Self-Report;Patients;perceived stress;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;placebo group;Placebos;Polysomnography;pre-clinical;Pre-Clinical Model;primary outcome;Process;Public Health;Randomized;Randomized, Controlled Trials;receptor;Recovery;recruit;Relapse;Reporting;Research;Rodent Model;Role;Safety;Salivary;Sampling;secondary outcome;Signal Transduction;Sleep;Sleep disturbances;sleep onset;sleep pattern;Sleep Wake Cycle;Sleeplessness;Stress;stress reactivity;stress reduction;System;Time;Translating;Treatment outcome;United States;Urine;Wakefulness;Wrist

PROJECT_TITLE: Evaluating the Role of the Orexin System in Circadian Rhythms of Sleep and Stress in Persons on Medication-Assisted Treatments for Opioid Use Disorder


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE Mutations play critical roles in the development of cancers and have significant implications for treatment strategies for cancer patients. However, the functional consequences of most of these mutations, particularly in the context of heterogeneous cancer cells, remain unknown. Our study will demonstrate how we utilize single- cell genomic technology and a computational framework to engineer, track, and study the impact of various mutations on the subclonal properties of cancer, including growth.

PI_NAMEs: ANDOR, NOEMI  (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Address;Bioinformatics;Biological;Biological Assay;cancer cell;Cancer cell line;Cancer Center;cancer genomics;Cancer Model;Cancer Patient;Cell Line;Cells;cellular imaging;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;computer framework;computerized tools;Development;Engineering;Exhibits;Experimental Models;experimental study;Genes;Genetic;Genetic Transcription;Genomics;Growth;Heterogeneity;Individual;insight;interest;Malignant Neoplasms;malignant stomach neoplasm;Microscopic;Modeling;Monitor;Mutation;Mutation Analysis;Phenotype;Play;Population;Primary Neoplasm;Property;PTEN gene;Reproducibility;Reproducibility of Results;Resolution;Role;single cell genomics;single cell sequencing;single-cell RNA sequencing;System;Systems Integration;Technology;Time;TP53 gene;Transcript;treatment strategy;tumor;Tumor Cell Line

PROJECT_TITLE: IMAT-ITCR Collaboration: Engineering model-based systems to monitor and steer subclonal dynamics


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Pediatric;Precision Medicine

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PI_NAMEs: LEWIS, MEGAN A (contact);UHRIG, JENNIFER D

PROGRAM_OFFICER_NAME: MCMASTER, SYDNEY JAYD

PROJECT_TERMS: All of Us Research Program;Child;Communities;community collaboration;community organizations;design;digital;experience;Family;Health Campaign;Lead;Participant;Persons;recruit;Research;Testing;virtual;Youth

PROJECT_TITLE: All of Us Research Program Engagement and Retention Innovators


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Sensory over-responsivity (SOR), or increased reactivity to and avoidance of sensory stimuli, is associated with substantial anxiety, distress, and social difficulties and affects about two-thirds of children with common neurodevelopmental disorders including autism spectrum disorder (ASD) and nearly one-fifth of school-age children overall. The proposed research tests the hypothesis that neural mechanisms of sensory prediction are attenuated in children with SOR by assessing whether children with SOR (including children with and without ASD) exhibit diminished neural measures of sensory adaptation, suppression, and surprise relative to typically developing children without SOR. Drawing upon discoveries from sensory neuroscience, the proposed work aims to determine whether mechanisms of sensory prediction in specific brain areas are disrupted in SOR, thereby dramatically improving our understanding of the neural correlates of SOR and highlighting targets for future interventions.

PI_NAMEs: SCHWARZLOSE, REBECCA  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Affect;Anxiety;Anxiety Disorders;Area;Attenuated;Auditory;Auditory area;autism spectrum disorder;autism symptoms;autistic children;Award;base;Basic Science;Brain;career;Child;Childhood;Clinical;Committee Members;Communities;complex data;cost;Data;Data Set;Development;Diagnosis;Distress;effective intervention;Etiology;Event;Exhibits;experience;Family;Fright;Functional impairment;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;Health;Impairment;improved;innovation;insight;Institution;Intervention;Knowledge;Learning;Location;Measurable;Measurement;Measures;Mental disorders;Mentors;multilevel analysis;neural;neural correlate;neuroadaptation;Neurodevelopmental Disorder;neuromechanism;Neurosciences Research;Noise;novel;novel strategies;nutrition;Pathway interactions;peer;Personal Satisfaction;Phase;poor sleep;Prevalence;Psychopathology;Reaction;recruit;Research;Research Personnel;response;Rest;Risk;Running;Scanning;School-Age Population;Scientific Advances and Accomplishments;Scientist;Sensory;sensory mechanism;sensory neuroscience;sensory stimulus;Signal Transduction;Site;skills;social;Social isolation;Standardization;Stimulus;success;Symptoms;Tactile;Techniques;Testing;tool;Training;translational approach;Work

PROJECT_TITLE: Neural mechanisms of sensory over-responsivity in children with and without ASD

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

PHR: Narrative: Despite the high prevalence and urgency for early diagnosis, Intimate Partner Violence (IPV) remains profoundly underdiagnosed. Our objective is to develop a novel clinical decision support tool derived from historical radiological and clinical data that provides IPV risk and severity prediction in every patient encountered at the point of care. The automated IPV risk and severity predictions can then be integrated into clinical care to transform the care plan for victims and make the “invisible” visible.

PI_NAMEs: KHURANA, BHARTI  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Accident and Emergency department;Acute;Age;Algorithms;Automated Clinical Decision Support;Awareness;Caring;case control;Chronic;Chronic Disease;Chronology;Clinical;clinical care;Clinical Data;clinical decision support;clinical practice;clinical predictors;clinical risk;Clinical/Radiologic;cohort;Computerized Medical Record;convolutional neural network;COVID-19 pandemic;craniofacial;Cues;Data;Data Set;Decision Support Model;Dedications;Diagnosis;Dimensions;Early Diagnosis;Early identification;Elderly;evidence base;experience;face bone structure;Feedback;Feeling;Fracture;Fright;Gender;Goals;Harvest;Health;health care settings;High Prevalence;Homicide;Image;imaging study;improved outcome;Injury;Institution;interdisciplinary approach;Intervention;intimate partner violence;Knowledge;Label;Language;Lead;Life;limb bone;Location;machine learning algorithm;machine learning model;Medical;men;Methods;Modality;model building;Modeling;multidisciplinary;multimodal learning;multimodal modeling;multimodality;musculoskeletal injury;Neural Network Simulation;Non-accidental;non-verbal;novel;pandemic disease;Pathology;Patient Care;patient population;Patient Self-Report;Patients;Pattern;pediatric trauma;Performance;Phase;Physicians;pilot test;Play;point of care;predictive modeling;predictive tools;prevent;psychological violence;Public Health;Questionnaires;Race;radiologist;Radiology Specialty;Recording of previous events;recurrent neural network;Reporting;repository;Research;Resource Sharing;Risk;Risk Factors;risk stratification;Role;Safety;Screening procedure;Sensitivity and Specificity;serial imaging;severe injury;Severities;sexual violence;Shame;Site;social;social stigma;Social Workers;support tools;Survivors;System;telehealth;tertiary care;Testing;Time;tool;Translating;Visit;Visualization;Woman

PROJECT_TITLE: Making the invisible visible: An automated clinical decision support tool for Intimate Partner Violence Risk and Severity Prediction (AIRS)

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Cold exposure increases blood flow and thermogenesis in brown adipose tissue and improves systemic glucose and lipid metabolism. The proposed studies will delineate how these porcesses are regulated by distinct subclasses of sympathetic neurons.

PI_NAMEs: ZELTSER, LORI M (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Ablation;Adrenergic Receptor;Affect;arteriole;Biological Assay;Blood flow;Blood Vessels;Brown Fat;Cardiovascular Diseases;Denervation;Development;Diabetes Mellitus;diet-induced obesity;Dissociation;Electrophysiology (science);experimental study;Funding;Genetic;Glucose;glucose metabolism;glucose tolerance;glucose uptake;Goals;High Fat Diet;Human;Imaging Techniques;improved;in vivo;Knowledge;lipid metabolism;loss of function;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Molecular;mouse genetics;Nerve;Neurons;novel;novel therapeutics;Obesity;Organ;Peripheral;pharmacologic;Predisposition;Prevalence;Process;Regulation;response;Signal Transduction;stem;Sympathetic Nervous System;System;Text;Thermogenesis;Thinness;tool;Triglycerides;uptake;vasoconstriction;Vasodilation;Viral

PROJECT_TITLE: Vascular sympathetic neurons in brown adipose tissue and systemic metabolism

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Dysfunction of pre-sympathetic neurons in the hypothalamic paraventricular nucleus (PVN) is implicated as a potentially causal factor in major cardiovascular and metabolic diseases in which sympathetic nerve activity becomes chronically elevated. A large and rapidly expanding number of factors has been implicated in autonomic dysfunction, but there is presently little evidence from which to generate specific hypotheses for how these pathogenic factors disrupt the normal balance of synaptic excitation and inhibition in the PVN. Proposed studies will provide new and potentially important insight into the basic mechanisms that generate and dynamically defend the strength of synaptic inhibition by GABA, which normally ensures that PVN neurons are held nearly quiescent in the unstressed animal. Pathogenic mechanisms that activate PVN pre-sympathetic neurons must subvert or overwhelm these fundamental mechanisms of synaptic homeostasis in order for sympathetic nerve activity to become chronically elevated.

PI_NAMEs: TONEY, GLENN M (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acute;acute stress;Angiotensin II;Animals;Anti-Hypertensive Agents;Automobile Driving;Autonomic Dysfunction;Bathing;Behavior;Brain;Cardiovascular Diseases;Cell model;Cell Nucleus;Chronic;clinical efficacy;CRISPR/Cas technology;density;Dependovirus;Disease;Ensure;Equilibrium;excitatory amino acid transporter 3;excitatory neuron;Experimental Water Deprivation;Exposure to;Functional disorder;functional outcomes;GABA-A Receptor;gamma-Aminobutyric Acid;Generations;Genes;Glutamate Transporter;Glutamates;Goals;Heart failure;Homeostasis;Hypertension;improved;in vivo;Individual;Injections;insight;Interruption;Kinetics;knock-down;Knowledge;Label;Lamina Terminalis;Link;Mediating;Metabolic Diseases;Modeling;mouse Cre recombinase;mouse model;Mus;Nerve;Neurons;novel;Nuclear;optogenetics;overexpression;paraventricular nucleus;Pathogenicity;Pathologic;photoactivation;Physiologic pulse;Physiological;Play;postsynaptic;preoptic nucleus;Preparation;preservation;presynaptic;prevent;Probability;Process;Property;Prosencephalon;Recovery;response;Rest;restoration;retrograde transport;Role;Rose Bengal;Saline;salt intake;Slice;stressor;Synapses;synaptic depression;synaptic inhibition;Synaptic Vesicles;Transgenic Mice;uptake;Vesicle;vesicular release;Viral;Virulence Factors;Virus

PROJECT_TITLE: Mechanisms of Synaptic Homeostasis Governing Pre-Sympathetic Neurons in the Hypothalamic Paraventricular Nucleus

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


PHR: Narrative The proposed research will develop bioanalytical and imaging technologies to address unmet needs in early diagnosis of type-1 diabetes, and enable non-invasive monitoring of disease progression to facilitate preventive therapies.

PI_NAMEs: FU, DAX  (contact);POMPER, MARTIN G;YU, LIPING

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Address;Autoantibodies;Autoantigens;autoimmune pathogenesis;Autoimmune Process;Autoimmune Responses;Beta Cell;Binding;Biochemical;Biological Assay;Biosensor;Birth;case-based;cell injury;Cell surface;Cells;Child;chronic autoimmune disease;Clinical;Clinical Data;clinical diagnosis;clinical practice;cohort;Dedications;Detection;Development;diabetic;Diabetic mother;Diagnostic;diagnostic value;Disease Marker;Disease Progression;Early Diagnosis;Epitope spreading;Epitopes;Evidence Based Medicine;extracellular;Fathers;Human;human population study;Imaging technology;in vivo;Insulin;insulin dependent diabetes mellitus onset;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;islet autoimmunity;Islet Cell;Islets of Langerhans;Location;longitudinal analysis;Maintenance;Membrane;Membrane Proteins;membrane reconstitution;Molecular Conformation;non-invasive monitor;novel marker;Pathway interactions;Patients;pediatric patients;peripheral blood;Phase;Populations at Risk;pre-clinical;Prevalence;Preventive therapy;Process;protective effect;Recommendation;Research;seroconversion;Serum;Structure of beta Cell of islet;Surface;Surface Antigens;Technology;Text;tool;Translations;Work;Zinc;zinc-binding protein

PROJECT_TITLE: ZnT8-specific bioanalytical tools for probing autoimmune destruction of pancreatic beta-cells in type-1 diabetes

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Liver Cancer;Liver Disease;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: TUCSON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Rates of non-alcoholic fatty liver disease (NAFLD) and liver cancer are highest for Mexican-origin adults in the Southern Arizona U.S.-Mexico border region, highlighting a critical need to improve liver disease and cancer health literacy to reduce the disparities among this high-risk population. The proposed research will address this gap by implementing a culturally tailored, multi-channel educational communication campaign, including promotora-led outreach, to increase knowledge and public awareness of liver disease and liver cancer risk factors in Mexican-origin adults. This effort will have a significant public health impact by contributing evidence to the Community Preventive Services Task Force for engaging promotoras de salud (community health workers) in liver disease management to improve health outcomes, including liver cancer.

PI_NAMEs: MERCHANT, JUANITA L. (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Administrative Supplement;Adult;Advisory Committees;aged;Arizona;Awareness;Cancer Center;Cancer Center Support Grant;cancer education;Cancer Etiology;cancer prevention;cancer therapy;Catchment Area;Cause of Death;Cessation of life;Communication;Communities;Community Health Aides;Disease Management;disorder prevention;Disparity;disparity reduction;economic cost;Education;effectiveness evaluation;Ethnic Origin;Ethnic Population;experience;Federally Qualified Health Center;Gender;General Population;Health;health literacy;high risk;high risk population;Hispanic;Hispanic Populations;Hispanic Women;improved;Incidence;Knowledge;Liver diseases;Malignant neoplasm of liver;Malignant Neoplasms;men;Mexican;Mexico;Morbidity - disease rate;mortality;Multimedia;Neighborhood Health Center;non-alcoholic fatty liver disease;Not Hispanic or Latino;Outcome;outreach;Population;Prevalence;Preventive service;Primary carcinoma of the liver cells;Public Health;Race;racial population;Recommendation;Research;Risk Factors;screening;tool;Underserved Population;Universities;Work

PROJECT_TITLE: University of Arizona Cancer Center - Cancer Center Support Grant [MICEO Administrative Supplement]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Current antibacterial treatment strategies for peri-implantitis lack efficacy in resolving the destructive inflammation that causes loss of jawbone, which necessitates the comprehensive study of microbial biofilm pathogenicity around implants. This study aims to understand the role of 1/. parvula in the polymicrobial shift that takes place in the pathogenesis of Titaniummediated peri-implantitis by focusing upon its ability to crossprotect pathogenic bacteria from oxidative environmental stress.

PI_NAMEs: KOTSAKIS, GEORGIOS  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Abscess;Address;Anti-Bacterial Agents;antimicrobial;bacterial genetics;Biodiversity;Biological Models;catalase;Cell Communication;Cells;Characteristics;clinically relevant;Coculture Techniques;Collaborations;commensal bacteria;commensal microbes;Communities;Competence;cross immunity;Data;Dental;Development;Disease;DNA;Drug Metabolic Detoxication;dysbiosis;Ecology;Electroporation;Environment;Essential Genes;experimental study;Exposure to;fitness;Fusobacterium nucleatum;Gene Mutation;gene network;Generations;Genes;Genetic;Goals;Grant;Growth;Harvest;Health;Homeostasis;human data;Implant;individualized medicine;infancy;Inflammasome;Inflammation;Inflammatory;Investigation;knowledge translation;Maintenance;Mediating;member;Methodology;microbial;Microbial Biofilms;Microbiology;microbiome;Modeling;Molecular;Molecular Genetics;Mus;Mutagenesis;Mutagens;Mutation;mutualism;Nutrient;opportunistic pathogen;Oral mucous membrane structure;Organism;Orthopedics;Parents;particle;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;peri-implantitis;Periodontitis;Phase;Plasmids;Play;polymicrobial biofilm;Population;Population Analysis;Porphyromonas gingivalis;Protocols documentation;Reactive Oxygen Species;Regulon;Relapse;Research;Research Personnel;Respiratory Burst;RNA;Role;Sampling;Signal Pathway;Stress;synergism;System;Techniques;Testing;Time;Titanium;tool;tool development;Training;transcriptome;transcriptome sequencing;translational model;Translational Research;transposon sequencing;treatment strategy;uptake;Veillonella;Veillonella parvula;Virulence Factors

PROJECT_TITLE: Commensal modulation of Peri-implant Microbiome Dysbiosis via Veillonella parvula

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-M]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CHICAGO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Asthma and allergic diseases are among the most common chronic diseases in children and adults, yet therapeutic advances have been incremental. We propose here a highly integrated program to discover and define functions for causal variants and causal genes associated with asthma and allergic diseases, with a focus on variants and genes that impart risk through their effects on lung-resident cells and are promising therapeutic targets.

PI_NAMEs: NOBREGA, MARCELO A.;OBER, CAROLE  (contact);SPERLING, ANNE I.

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Address;Adult;Affect;Allergic Disease;Allergic rhinitis;Asthma;Bacterial Artificial Chromosomes;biobank;Biological;Biology;Birth;bronchial epithelium;candidate identification;Categories;causal variant;Cell Physiology;cell type;Cells;Child;Chronic Disease;Clinical;clinical heterogeneity;clinical phenotype;cohort;cost;Data;data management;Development;Diagnosis;Disease;disease heterogeneity;disorder risk;disorder subtype;Engineering;Enhancers;Environment;Environmental Exposure;Epithelial Cells;Epithelium;ethnic diversity;Ethnic Population;Food Hypersensitivity;gene discovery;gene function;Genes;Genetic;Genetic Risk;genome wide association study;genome-wide;Genomics;Goals;Health Care Costs;Healthcare Systems;Heritability;Human;Hypersensitivity;Immune;Immunologics;Immunology;Individual;Infrastructure;Knowledge;Link;Lung;Lymphocyte;Maps;Molecular;mouse model;multi-ethnic;Myeloid Cells;new therapeutic target;novel;Outcome;Pathogenesis;Peripheral;personalized medicine;Phenotype;precision medicine;Process;programs;Quantitative Trait Loci;Reporting;Research Personnel;Resources;respiratory smooth muscle;Rest;Risk;risk variant;Role;Services;skin hypersensitivity;Smooth Muscle;Specificity;Technology;Testing;Therapeutic;therapeutic target;Tissues;tool;trait;transcriptome sequencing;Translations;Variant;Work

PROJECT_TITLE: Integrated genetic, omic, and immunologic studies to identify endotypes and novel drug targets for asthma and allergic diseases


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE The ultimate goal of the proposed work is to develop novel insulin-pramlintide co-formulations in combination with incretin hormone therapy to enable transformational new treatments for diabetes more closely mimicking endogenous hormone secretion in response to increases in blood glucose. The most challenging aspect of optimal glycemic control in the treatment of diabetes is limiting large increases in blood glucose after a meal. Our novel combination hormone therapy will yield unprecedented postprandial glycemic control and catalyze the development of a powerful tool for diabetes management affording thus far unrealized therapeutic impact.

PI_NAMEs: APPEL, ERIC ANDREW (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Agonist;analog;Animal Model;Artificial Pancreas;Beta Cell;Biocompatible Materials;Blindness;Blood Glucose;blood glucose regulation;Body Weight;Cell Physiology;Clinical;clinically relevant;Combined Modality Therapy;copolymer;Coupled;Development;diabetes management;Diabetes Mellitus;diabetic;diabetic rat;Diagnosis;Disease;drug candidate;Drug Formulations;Drug Kinetics;Eating;Excipients;Excretory function;Family suidae;Formulation;Gastric Emptying;GLP-I receptor;Glucagon;glucagon-like peptide 1;Glucose;glycemic control;Goals;Heart Diseases;Hormone secretion;hormone therapy;Hormones;Hyperglycemia;improved;In Vitro;incretin hormone;Individual;Injections;innovation;Insulin;Insulin, Lispro, Human;Insulin-Dependent Diabetes Mellitus;Intestinal Secretions;islet amyloid polypeptide;Islet Cell;L Cell (Intestine);limb loss;liraglutide;mimetics;monomer;Neurotransmitters;novel;novel strategies;NovoLog;Nutrient;Obesity;Oral;Outcome;Pancreas;Patients;peptide hormone;Persons;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Polymers;Pramlintide;prevent;Process;Production;Pump;Regimen;Replacement Therapy;Research;Residual state;response;side effect;Structure of beta Cell of islet;Subcutaneous Injections;synergism;Technology;Testing;Therapeutic;Time;tool;Treatment Efficacy;Treatment Protocols;United States;Work

PROJECT_TITLE: Co-Formulations of Amylin Analogues with Insulin Analogues for Treatment of Diabetes

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: Aortic aneurysms are a potentially deadly expansion of the main blood vessel carrying blood from the heart. Aortic aneurysms have no medical therapy and often have no symptoms. They have a very high mortality (85-90%) if they expand, go undetected, and rupture or dissect. These aneurysms are very prevalent in the male Veterans population (especially Veterans who smoke) with estimates running as high as 15%. The goal of this application is to understand the relationship between aortic aneurysms and gut bacteria, and to uncover the molecular underpinnings of how gut bacteria protect from development of aortic aneurysms. This understanding could form the basis of new therapies that prevent or treat aortic aneurysms so prevalent in the VA population.

PI_NAMEs: IRANI, KAIKOBAD J. (contact)

PROJECT_TERMS: Abdomen;abdominal aorta;Abdominal Aortic Aneurysm;acylcarnitine;Age Years;aged;Aneurysm;Angiotensin II;Antibiotics;Aorta;Aortic Aneurysm;Aortitis;Architecture;arterial remodeling;Bacteria;Bioenergetics;Blood;Blood Vessels;cell dedifferentiation;Cellular Metabolic Process;cohort;cooperative study;Cross-Sectional Studies;Data;Death Rate;Detection;Development;Diameter;differential expression;Dilatation - action;Disease;Dissection;Down-Regulation;dysbiosis;Epigenetic Process;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;fecal transplantation;gain of function;Gene Modified;Genes;Germ-Free;Glucose;Goals;gut bacteria;gut dysbiosis;gut microbiome;gut microbiota;Health;Health system;Healthcare Systems;Heart;Human;human disease;Incidence;long chain fatty acid;loss of function;male;Medial;Mediating;Medical;Metabolic;metabolomics;microbiome;microorganism;MicroRNAs;military veteran;Molecular;Morbidity - disease rate;mortality;Mus;Nicotine;novel therapeutics;Observational Study;Oral cavity;oxidation;Pathogenesis;Pathway interactions;Phenotype;Plasma;Play;Population;Population Study;Predisposition;preference;Prevalence;prevent;primary care clinic;Recording of previous events;Risk;Role;Running;Rupture;Severities;Skin;Smoke;Smooth Muscle;Smooth Muscle Myocytes;Symptoms;Testing;Tissues;tool;trait;United States Department of Veterans Affairs;Untranslated RNA;Vascular Smooth Muscle;Veterans;Work

PROJECT_TITLE: Nexus between miR-204, gut microbiome, and aortic aneurysmal disease


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: Aurora

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Improving primary prevention of opioid use while effectively treating pain is a pillar of the NIDA HEAL response to the opioid crisis that would benefit greatly from research producing actionable data. The CDC opioid prescribing guidelines (update late `22) define evidence-based practices to improve opioid related morbidity and mortality by decreasing opioid exposures and high-risk opioid use, but lack robust effectiveness data. This single system research project will support the development of EHR based clinical decision support tools to promote CDC guideline recommendations followed by an evaluation of patient centered outcomes by linking provider prescribing to existing Prescription Drug Monitoring Program, insurance claims and death data sets.

PI_NAMEs: HOPPE, JASON  (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Address;Agreement;Architecture;Behavior;Caring;Cessation of life;Chronic;Clinical;clinical decision support;Clinical effectiveness;Cluster randomized trial;Common Data Element;Communities;contextual factors;Cost Effectiveness Analysis;Dangerousness;Data;data dashboard;Data Element;data infrastructure;Data Linkages;data quality;Data Set;Development;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Electronic Health Record;Eligibility Determination;Evaluation;evidence based guidelines;Evidence based practice;Future;Goals;Guidelines;health care service utilization;Health system;high risk;Hospitals;implementation barriers;implementation framework;implementation outcomes;implementation science;implementation strategy;improved;individual patient;Infrastructure;innovation;Institutional Review Boards;insurance claims;Integrated Health Care Systems;Learning;Link;Medicine;Morbidity - disease rate;mortality;National Institute of Drug Abuse;non-opioid analgesic;Opioid;opioid abuse;Opioid Analgesics;opioid epidemic;opioid exposure;opioid mortality;opioid overdose;opioid policy;opioid tapering;opioid use;Outcome;Outcome Measure;Outpatients;Overdose;Pain;Pain management;Patient-Focused Outcomes;Patients;pilot test;Positioning Attribute;Practical Robust Implementation and Sustainability Model;pragmatic implementation;prescription monitoring program;prescription opioid;Primary Prevention;Process;process evaluation;programs;prospective;Provider;provider behavior;public health priorities;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reporting;Research;Research Priority;Research Project Grants;response;rural setting;Safety;suburb;success;support tools;System;systems research;Testing;Time;tool;Training;treatment as usual;United States National Institutes of Health;Update;user centered design;Visit;Work

PROJECT_TITLE: Improving pain management and opioid safety through a systemwide, data driven evaluation of the CDC opioid prescribing guideline best practices and the use of Clinical Decision Support


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ROCKVILLE

ORG_NAME: BIOQUAL, INC.

PI_NAMEs: LEWIS, MARK  (contact)

PROJECT_TERMS: Advanced Development;AIDS Vaccines;Award;Clinical;Complement;Contracts;Data;Development;Evaluation Studies;Funding;Grant;HIV vaccine;Immunotherapy;Investigator-Initiated Research;Local Microbicides;Maintenance;Modality;National Institute of Allergy and Infectious Disease;nonhuman primate;Occupational activity of managing finances;pre-clinical;preclinical evaluation;preclinical study;Preparation;Prevention;Prevention strategy;programs;Reporting;Research Personnel;Resources;vaccine candidate;Vaccine Design;vaccine development;vaccine evaluation;Vaccine Research;Vaccines

PROJECT_TITLE: Simian Vaccine Evaluation Unit (SVEU) - Core Activities


ORG_CITY: GAITHERSBURG

ORG_NAME: SCIENTIFIC CONSULTING GRO

PI_NAMEs: WARNER, SUSIE  (contact)

PROJECT_TERMS: Logistics;National Institute of Diabetes and Digestive and Kidney Diseases;research and development;symposium

PROJECT_TITLE: NIDDK SCIENTIFIC CONFERENCE & LOGISTICS SUPPORT


ORG_NAME: RIPPLE EFFECT COMMUNICATIONS, INC.

PI_NAMEs: NA, NA  (contact)

PROJECT_TERMS: Evaluation;National Institute of Diabetes and Digestive and Kidney Diseases;programs

PROJECT_TITLE: NIDDK - EVALUATION OF NIDDK OMHRC PROGRAMS - NMA AND NMRI AND HARP


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Cancer

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PI_NAMEs: BEUMER, JAN  (contact)

PROJECT_TERMS: analytical method;anti-cancer;Authorization documentation;base;Biological Assay;Biological Availability;Blood;Chemical Structure;Chromatography;Collection;Contractor;Contracts;cost estimate;Data;Data Analyses;design;Dose;drug candidate;Drug Kinetics;drug-like compound;Exercise;Formulation;Hemorrhage;High Pressure Liquid Chromatography;Laboratories;Methods;Modeling;Modification;Molecular Weight;Oral;Plasma;Procedures;Property;Protocols documentation;Rattus;Route;Sampling;Solubility;Testing;Time;Validation;Visual

PROJECT_TITLE: PHARMACOKINETIC AND ORAL BIOAVAILABILITY STUDIES IN RATS


FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

ORG_NAME: NATIONAL CANCER INSTITUTE

PROJECT_TERMS: 3-Dimensional;Acute;Biological Models;Chronic;Health;Longevity;microphysiology system;Performance;stressor;Tissues;United States National Aeronautics and Space Administration

PROJECT_TITLE: Extended Longevity of 3D Tissues and Microphysiological Systems for Modeling of Acute and Chronic Exposures.


NIH_SPENDING_CATS: Cancer;Clinical Research;Diabetes;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PHR: Narrative. The Consortium for the Study of Pancreatitis: Pittsburgh Clinical Center (PCC) is a clinical- translational program at the University of Pittsburgh and UPMC designed to conduct studies related to chronic pancreatitis, diabetes and pancreatic cancer. As a member of the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC), the PCC will participate in collaborative studies planned by the consortium. The track record of accomplishments of the PCC in the CPDPC as well as leadership and contributions to other collaborative networks will ensure continued success and effectiveness of the CPDPC.

PI_NAMEs: BRAND, RANDALL ;YADAV, DHIRAJ  (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: acute pancreatitis;Ancillary Study;Area;authority;Bioinformatics;Biological;Biological Markers;Biometry;chronic pancreatitis;Clinical;clinical center;clinical infrastructure;clinical translation;cohort;Collaborations;data exchange;data management;design;Diabetes Mellitus;disorder subtype;Effectiveness;Endocrinology;Ensure;Epidemiology;Funding;Genetic;Image;Infrastructure;Leadership;Malignant neoplasm of pancreas;member;multidisciplinary;organizational structure;Pain;Pancreatic Diseases;Pancreatitis;Patients;Phenotype;Physiology;programs;Publications;randomized, clinical trials;Recurrence;Research;Research Infrastructure;Research Personnel;Resources;Risk;Sampling;Screening for cancer;success;Universities;Urine;working group


NIH_SPENDING_CATS: Burden of Illness;Clinical Research;Diabetes;Digestive Diseases;Genetics;Pediatric;Prevention

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Chronic pancreatitis (CP) is an emerging, but poorly understood condition in children that significantly impacts quality of life with high healthcare costs. The objective of this application is to delineate the natural history of pediatric CP through careful prospective analysis of INSPPIRE-2 cohort, to define the impact of genetic modifiers on disease course and to determine the mechanisms involved in pancreatogenic diabetes mellitus. Our long-term goal is to develop diagnostic modalities, prognostic factors and better treatment approaches for pediatric chronic pancreatitis.

PI_NAMEs: CHUGH, ANKUR A;COHEN, REUVEN ZEV;GIEFER, MATTHEW ;PHADKE, MADHURA ;UC, ALIYE  (contact)

PROJECT_TERMS: Acute;acute pancreatitis;Administrative Supplement;Adult;Age;Aggressive course;Ancillary Study;Autoantibodies;Autoimmunity;Beta Cell;blood glucose regulation;burden of illness;C-Peptide;Characteristics;Child;Childhood;chronic pancreatitis;Clinical;Cognitive Therapy;cohort;Cohort Analysis;Cystic Fibrosis Transmembrane Conductance Regulator;Defect;demographics;Diabetes Mellitus;Diagnosis;Diagnostic;diagnostic development;Disease;Disease Progression;early onset;Endocrine;Environmental Risk Factor;Exocrine pancreatic insufficiency;Fibrosis;Functional disorder;Funding;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic Screening;genetic variant;genomic locus;Glucagon;glucagon-like peptide 1;Glucose;glucose tolerance;Goals;Health Care Costs;health related quality of life;Hyperlipidemia;Hypertriglyceridemia;Image;Impaired health;Incidence;innovation;insight;Insulin;Interdisciplinary Study;International;islet;Islet Cell;longitudinal analysis;Modality;Natural History;Onset of illness;Outcome;Pain;pain-related disability;Pancreatic Polypeptide;Pancreatitis;Pathogenicity;Patient Outcomes Assessments;Pediatric cohort;Peptides;Physiologic calcification;polypeptide;Predisposing Factor;premature;Prevalence;Prognostic Factor;prospective;Quality of life;Recurrence;Research Personnel;response;Risk;Risk Factors;Risk Marker;risk variant;SPINK1 gene;Susceptibility Gene;Testing;Therapeutic;United States National Institutes of Health;Variant;virulence gene;Work

PROJECT_TITLE: Year 10 Administrative Supplement to INSPPIRE 2


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: 2024 NHSN Conference Administrative Supplement Project Narrative Hispanics constitute the largest racial/ethnic underrepresented group in the United States and are disproportionately impacted by substance use disorder, such as drug types, alcohol, tobacco, and more. There is a pressing need to study the biological, individual, familial, community, legal, and contextual factors that differentially affect substance use, its consequences, and the use of treatment services in Hispanic populations through interdisciplinary and translational approaches. The proposed annual NHSN conference will continue to serve as the premier venue for transdisciplinary, interdisciplinary, and interprofessional scientific discussions on strategies to minimize the impact of substance use disorder on health disparities in Hispanics and other underrepresented groups.

PI_NAMEs: MOLINA, PATRICIA E. (contact)

PROGRAM_OFFICER_NAME: REICHEL, CARMELA MARIE

PROJECT_TERMS: Administrative Supplement;Affect;Alcohols;Area;Biological;Communities;comorbidity;contextual factors;Dedications;Development;Discipline;Drug abuse;Environmental Health;Epidemiology;Ethnic Origin;Fostering;Funding;Future;gender diverse;Geographic Locations;Grant;health disparity;health equity;Health Policy;Hispanic;Hispanic Populations;implementation science;improved;Individual;innovation;interdisciplinary approach;Intervention;Legal;meetings;member;Mentors;multidisciplinary;Neurobiology;Neurosciences;peer support;Pharmaceutical Preparations;Policies;Psychology;Race;recruit;Research;Science;Scientist;Sociology;substance use;Substance Use Disorder;Support Groups;symposium;Tobacco;Toxicology;translational approach;Translational Research;treatment services;Underrepresented Minority;Underrepresented Populations;United States;Women's Health

PROJECT_TITLE: National Hispanic Science Network on Drug Abuse (NHSN) 2024 Conference Administrative Supplement


NIH_SPENDING_CATS: Cancer;Clinical Research;Diabetes;Nutrition;Obesity;Prevention;Uterine Cancer;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Obesity increases the risk of death from endometrial cancer and predisposes to high levels of insulin; however, it is unclear if these findings are directly linked. The growth of endometrial cancer cells is stimulated by insulin via the phosphatidylinositol 3-kinase (PI3K) pathway. This proposal will target the PI3K pathway in human endometrial cancer using a combination of dietary and pharmacologic strategies that reduce insulin together with small molecule inhibitors of PI3K to prevent the growth of endometrial cancer.

PI_NAMEs: GONCALVES, MARCUS DASILVA (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute;Address;Adult;Adverse effects;Animal Model;Apoptosis;Apoptotic;Biochemical;Biochemical Markers;Blood;cancer cell;cancer therapy;cancer type;Carbohydrates;Carcinoma;cell growth;Cessation of life;Clinical;clinical care;Clinical Data;clinical practice;Clinical Research;Clinical Trials;combat;Combined Modality Therapy;Consumption;Data;Death Rate;detection of nutrient;Development;Diazoxide;Diet;dietary;Dietary Intervention;drug efficacy;effectiveness validation;Endocrine system;Endocrinologist;Endometrial Carcinoma;Epithelium;feasibility trial;feeding;Genetic;Glucose;glycemic control;Goals;Growth;Histologic;hormone therapy;Human;Human Genetics;Hyperglycemia;Hyperinsulinism;Implant;Incidence;inhibitor;Insulin;insulin signaling;Intervention;Intervention Trial;kinase inhibitor;Knowledge;Link;Malignant Female Reproductive System Neoplasm;Medical Oncologist;Memorial Sloan-Kettering Cancer Center;Metabolism;mortality risk;mouse model;Mus;Nature;novel;novel strategies;novel therapeutic intervention;Obesity;Obesity Epidemic;open label;Organoids;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Phase;phase 2 study;Phosphotransferases;PIK3CG gene;Potassium Channel;pre-clinical;Pre-Clinical Model;prevent;Proliferating;Publishing;Qualifying;Randomized;Recurrence;Research;response;Risk;Role;safety testing;Signal Pathway;Signal Transduction;small molecule inhibitor;Sodium;symporter;targeted treatment;Testing;Tissues;Translating;translational approach;translational scientist;treatment response;tumor;tumor growth;tumor initiation;Tumor Markers;tumor progression;Tumor Tissue;Urine;Uterus;Woman;Women's study;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Combination Therapies Targeting Insulin Signaling in Endometrial Cancer

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Pain Research;Primary Health Care;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Up to 60% of older adults have at least some persistent pain which is associated with impaired physical and emotional function and increased risk for morbidity and mortality. Older adults from underserved communities (e.g., low SES, racial and ethnic minorities, immigrants) are at the highest risk for negative pain outcomes, yet we lack nonpharmacological treatments within community health centers that serve them. Using the socioecological frameworks, Aaron’s stage model and Proctor’s implementation model, we aim to culturally adapt GetActive, an evidence-based mind-body activity program for chronic pain, to incorporate the values, facilitators, resources, and language, for disadvantaged older adults with chronic pain and routine implementation in the community based clinical settings that serve them.

PI_NAMEs: RITCHIE, CHRISTINE S;VRANCEANU, ANA-MARIA  (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Adult;adverse event risk;Agreement;Alternative Health;Area;Attention;Behavioral;Boston;Bypass;care seeking;Caring;chronic musculoskeletal pain;chronic pain;chronic pain management;Clinic;Clinical;Cognitive;Communities;community center;community clinic;community engaged research;Community Health;Complementary Health;coping;cost;Disadvantaged;disadvantaged background;Disparity population;economic disparity;Economics;effectiveness evaluation;effectiveness outcome;effectiveness/implementation trial;emotional functioning;Enrollment;Epidemic;ethnic minority;Ethnic Origin;evidence base;experience;falls;Feedback;Focus Groups;Fright;Funding;Growth;Health;health equity;Healthcare;Helping to End Addiction Long-term;high risk;Hybrids;Immigrant;Impaired cognition;implementation evaluation;implementation facilitators;implementation outcomes;improved;Intervention;Language;Life;Link;Loneliness;low socioeconomic status;Manuals;Measures;Medical;Methods;mind/body;mindfulness;Modeling;Morbidity - disease rate;mortality;multiple chronic conditions;Neighborhood Health Center;Nonpharmacologic Therapy;Nurse Practitioners;Nurses;older adult;Outcome;Pain;Pain intensity;Pain management;pain outcome;patient population;Patient Self-Report;Patients;Performance;Persistent pain;Pharmaceutical Preparations;Phase;Physical Function;physical impairment;Population;primary care practice;primary health center;Procedures;Proctor framework;programs;Provider;racial diversity;racial minority;Randomized;resilience;Resources;response;Risk;sedentary;self-compassion;side effect;skills;social;Social support;Thinking;Time;Training;treatment as usual;underserved community;Visit;Walking;Work

PROJECT_TITLE: Addressing the chronic pain epidemic among older adults in underserved community center; The GetActive+ study.


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: WACO

ORG_DEPT: CHEMISTRY

ORG_NAME: BAYLOR UNIVERSITY

ORG_STATE: TX

PHR: The proposed work will advance our understanding of the mechanisms of amyloid toxicity, paving the way to new approaches in treatment of neurodegenerative diseases. Through deeper understanding of the factors that determine the ability of proteins to catalyze new chemical transformations, the proposed work will help combat drug resistance and engineer enzymes to facilitate reactions not found in nature.

PI_NAMEs: KORENDOVYCH, IVAN V (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TITLE: Understanding Evolution of Protein Function Through Design

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROGRAM NARRATIVE This training program is specifically designed to train a new cadre of researchers and leaders to address major but as yet under-studied public health problems engendered by conditions prevalent in urban and rural informal human settlements (slums) of low and middle-income countries (LMIC). This training is relevant also to developed countries as informal settlements in the form of homeless encampments expand. Selected candidates will undergo field training on site in LMICs to develop new global health research skills framedwithin our project research theme of health equity.

PI_NAMEs: BARRY, MICHELE ;HARRIS, EVA ;KO, ALBERT ICKSANG (contact);MADHIVANAN, PURNIMA

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TERMS: Address;Africa;Arizona;Asia;California;career;Career Choice;career development;Caribbean region;Central America;Collaborations;Communities;Country;Dedications;design;Discipline;Disease;doctoral student;Eastern Europe;Educational workshop;Environmental Health;Exposure to;Faculty;faculty mentor;global health;Health;health equity;Health equity research;HIV;Human;Inequity;Injury;Institution;Interpersonal Violence;low and middle-income countries;member;Mental Health;Mentors;Mentorship;Methods;multidisciplinary;National Institute of Environmental Health Sciences;Persons;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Methodology;Research Personnel;Research Support;Research Training;Rural;Scholars Program;Site;skills;Slum;South America;Substance abuse problem;Supervision;Time;Training;Training Programs;Universities;Vulnerable Populations;Women's Health;Work

PROJECT_TITLE: GHES - NIEHS - Campmier


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: The human genome has been sequenced, and yet so much is unknown about what it does; what we do know is scattered across multiple, heterogeneous data sources that are difficult to integrate. The Phenomics-First Resource (PFR) coordinates the efforts of a large community of researchers and clinicians to help interpret the relationship between the differences (called variants) in a patient’s genome and their physical characteristics (phenotypes). The PFR will gather and unify the data from numerous sources to advance genomic interpretation in clinical settings, and will empower both researchers and clinicians to overcome long-standing barriers to discovery and patient care.

PI_NAMEs: HAENDEL, MELISSA A (contact);MUNGALL, CHRISTOPHER J

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Address;Adoption;Algorithms;Basic Science;Biology;Case Study;Characteristics;Clinical;clinical care;Clinical Data;clinically actionable;Communities;community partnership;Complex;computational platform;Data;data integration;data modeling;Data Sources;data standards;database schema;Databases;Development;Diagnosis;Diagnostic;Disease;disease diagnosis;disease model;disease phenotype;empowerment;Evaluation;Face;Fast Healthcare Interoperability Resources;Frequencies;Functional disorder;gene function;Genes;Genetic Diseases;genetic variant;Genome;genomic variation;Genomics;Genotype;heterogenous data;Human;human disease;Human Genome;improved;Information Resources;interoperability;Journals;Knowledge;Link;Mainstreaming;Manuals;Medical Genetics;Methods;Modality;model organism;Modeling;Modernization;novel;Ontology;Outcome;Patient Care;patient registry;Patients;phenomics;Phenotype;phenotypic data;precision medicine;Process;prototype;Rare Diseases;Research;Research Personnel;Resources;Software Engineering;Source;Structure;System;Techniques;Technology;Terminology;tool;Variant;variant of unknown significance;Work

PROJECT_TITLE: A phenomics-first resource for interpretation of variants


PHR: PROGRAM NARRATIVE This training program is specifically designed to train a new cadre of researchers and leaders to address major but as yet under-studied public health problems engendered by conditions prevalent in urban and rural informal human settlements (slums) of low and middle-income countries (LMIC). This training is relevant also to developed countries as informal settlements in the form of homeless encampments expand. Selected candidates will undergo field training on site in LMICs to develop new global health research skills framed within our project research theme of health equity.

PROJECT_TERMS: Address;Africa;Arizona;Asia;California;career;Career Choice;career development;Caribbean region;Central America;Collaborations;Communities;Country;Dedications;design;Discipline;Disease;doctoral student;Eastern Europe;Educational workshop;Environmental Health;Exposure to;Faculty;faculty mentor;global health;Health;health equity;Health equity research;HIV;Human;Inequity;Injury;Institution;Interpersonal Violence;low and middle-income countries;member;Mental Health;Mentors;Mentorship;Methods;multidisciplinary;Persons;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Methodology;Research Personnel;Research Support;Research Training;Rural;Scholars Program;Site;skill acquisition;Slum;South America;Substance abuse problem;Supervision;Time;Training;Training Programs;Universities;Vulnerable Populations;Women's Health;Work

PROJECT_TITLE: GHES - ODP - Katabaro


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Precision Medicine

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: RELEVANCE Chronic rhinosinusitis (CRS) is an inflammatory disease that has substantial impacts on patient quality of life and health care resource utilization. This proposal focuses on enhancing the PI’s contributions in patient-oriented research focused on chronic rhinosinusitis pathogenesis, developing the PI’s mentorship skills and experience, and guiding the next generation of translational researchers in rhinology and paranasal sinus disease. Longitudinal multi-omic analysis of patient-derived samples will be used to identify novel mechanisms of disease and new targets for treatment.

PI_NAMEs: TURNER, JUSTIN H (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Academic Medical Centers;Adult;Affect;Airway Disease;airway inflammation;aspirin-exacerbated respiratory disease;Bacteria;Biological Markers;Biological Response Modifier Therapy;Biological Specimen Banks;career;Career Choice;Caring;Cells;Characteristics;chronic respiratory disease;chronic rhinosinusitis;Clinical;clinical practice;Clinical Research;Cohort Studies;Collection;Data;Development;Diagnosis;Disease;Educational Status;Elderly;Enrollment;Environmental Risk Factor;experience;Extramural Activities;Faculty;Functional disorder;Funding;Goals;Head and Neck Surgery;Healthcare;Heterogeneity;IL4 gene;Immune;Immunologics;immunoregulation;improved;improved outcome;individual patient;Inflammation;Inflammation Mediators;Inflammatory;Institution;interest;Interferons;Interleukin-13;Interleukin-5;Interleukin-6;Intervention;Knowledge;Link;Measurement;Mediator;Medical Students;member;Mentors;Mentorship;microbial colonization;microbial community;mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;minimally invasive;Mucous body substance;multiple omics;Natural Immunity;Nature;next generation;novel;novel therapeutics;Operative Surgical Procedures;Otolaryngology;Outcome Measure;Paranasal Sinus Diseases;Pathogenesis;Pathway interactions;patient oriented;patient oriented research;Patient Outcomes Assessments;patient population;Patient-Focused Outcomes;Patients;Pattern;personalized approach;personalized care;physical conditioning;Physicians;Population;Postdoctoral Fellow;Prevalence;Productivity;programs;prospective;Publications;Quality of life;Recording of previous events;Research;Research Personnel;Research Project Grants;Resources;Sampling;Scientific Advances and Accomplishments;Scientist;Seasons;Sinus;skills;Specimen;Structure;Surgeon;targeted treatment;Time;Tissue Banks;Tissues;transcriptomics;Translational Research;translational research program;translational scientist;translational study;undergraduate student;United States National Institutes of Health;Work

PROJECT_TITLE: Mentoring in Chronic Rhinosinusitis Pathophysiology and Mechanisms of Disease

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Cardiac fibrosis is a grim consequence for almost all myocardial injuries, currently with no cure in sight. To date, studies failed to identify therapeutic targets mainly due to the heterogeneity in fibroblast biology between disease types and even between various anatomical regions in the heart. The proposed study will utilize newly developed in vivo genetic tools to rigorously interrogate all of the extracellular matrix-producing fibroblasts within the heart in order to find common and disease-specific mechanisms underlying cardiac fibrosis.

PI_NAMEs: KANISICAK, ONUR  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Ablation;Acute;Acute Disease;Acute myocardial infarction;Adult;Angiotensins;aorta constriction;Back;base;Biology;Blood Vessels;Cardiac;cardiogenesis;Cell Differentiation process;Cell Lineage;cell type;Cells;Chronic;Chronic Disease;Cicatrix;Collagen;Compensation;coronary fibrosis;Data;Deposition;Development;Disease;disease model;electrical property;Embryonic Development;Endothelial Cells;epithelial to mesenchymal transition;Exhibits;experience;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Fibrosis;Flow Cytometry;gain of function;Gene Expression;Gene Expression Profile;Genetic;Goals;Heart;Heart Diseases;Heart failure;Heterogeneity;Histologic;Human;hypertensive;Impairment;in vivo;Inflammatory;Injury;innovation;Integrins;interstitial;Isoproterenol;Knock-out;Label;Ligands;loss of function;LoxP-flanked allele;mechanical properties;Mediator;Mesenchymal;migration;Minor;Modeling;Molecular;mouse model;Mus;Myocardial Infarction;myocardial injury;Myocardial rupture;Myocardium;Myofibroblast;novel;Outcome;Pathologic;Pathology;Pericytes;periostin;Perivascular Fibrosis;Phase;Play;Population;pressure;prevent;Process;Production;Proliferating;Proteins;Regional Anatomy;Reporter;Reporting;Role;Rupture;Series;single-cell RNA sequencing;Source;Testing;Therapeutic;therapeutic target;Time;Tissues;tool;transcriptome sequencing;translational potential;Ventricular;Vision;Work

PROJECT_TITLE: Regulators of extracellular matrix production during cardiac development and disease

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_STATE: PA

PHR: NARRATIVE Capsular polysaccharide (capsule) is the outermost barrier that protects bacteria from external threats and is required for colonization of the human gastrointestinal tract. The project areas proposed here focus on understanding how a predominant genera of gut bacteria regulates capsule abundance and attaches it to the bacterial cell surface. The results of the proposed projects have the potential to shed light on this fundamental process, which could be harnessed to restrict bacterial fitness in targeted niches.

PI_NAMEs: MIKE, LAURA ANZALDI (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Adherence;Amoeba genus;Anabolism;Area;Bacteria;bacterial fitness;Bacteriophages;capsule;Cell surface;Cells;Complex;Dehydration;Endogenous Factors;Environment;environmental change;Environmental Protection;environmental stressor;Epithelial Cells;Escherichia coli;Exogenous Factors;extracellular;fitness;flexibility;Foundations;Gastrointestinal tract structure;Genes;Genetic;Goals;Gram-Negative Bacteria;gut bacteria;gut colonization;Heterogeneity;Human;Immune Evasion;Intervention;Klebsiella;Laboratories;Membrane;Metabolic;Metabolism;Microbial Biofilms;Modeling;Nutrient;Polysaccharides;Population;Predatory Behavior;Predisposition;pressure;Process;Production;programs;Research;response;Sewage;Shapes;Signal Transduction;Soil;Source;Surface;ultraviolet irradiation;Vision

PROJECT_TITLE: Control of Klebsiella capsule biosynthesis and attachment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Data Science;Networking and Information Technology R&D (NITRD);Physical Activity;Prevention

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is collecting a large and complex multiomic dataset to understand how tens of thousands of molecules change in response to exercise. The Stanford Bioinformatics Center aims to serve MoTrPAC by organizing, analyzing, and sharing this vast collection of data. This work ensures that the results of the Consortium are robust, reliable, valid, and available and usable by the entire scientific community.

PI_NAMEs: ASHLEY, EUAN A (contact);WHEELER, MATTHEW THOMAS

PROGRAM_OFFICER_NAME: PAPANICOLAOU, GEORGE

PROJECT_TERMS: Address;Adopted;Bioinformatics;bioinformatics resource;bioinformatics tool;Clinical Data;cloud based;Collaborations;Communities;Complex;computerized data processing;Data;Data Analyses;Data Collection;Data Coordinating Center;data ecosystem;data integrity;data management;Data Management Resources;data pipeline;data resource;Data Set;data sharing;data standards;data tools;Development;differential expression;Documentation;Educational workshop;Ensure;Exercise;experience;Extracellular Matrix;FAIR principles;Funding;Health Benefit;improved;Infrastructure;innovation;insight;Metadata;Methods;Molecular;multidimensional data;Multiomic Data;multiple omics;novel;outreach;Phase;Physical activity;Quality Control;repository;Reproducibility;Research;Resources;response;Secure;success;System;Techniques;Tissues;tool;Training;Transducers;United States National Institutes of Health;usability;Vision;Visualization;Work

PROJECT_TITLE: Extracellular Matrix Adaptation to Exercise within MoTrPAC


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Infectious Diseases;Natural Products;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: ATHENS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative. New small molecule probes are critical to illuminating biology in ways that can be harnessed for the treatment of human disease. Our group is developing natural product-inspired chemical biology platforms that integrate chemical synthesis with sophisticated biological investigations to discover new phenomena relevant to priority disease areas (e.g., antibiotic-tolerant biofilm infections, cancer, opioid addiction). During this award, we will (1) expand our tryptoline ring distortion platform to generate new complex and diverse compounds, and perform an array of biological studies to explore their re-engineered activities, and (2) develop robust strategies to expand the spectrum of activity for halogenated phenazine biofilm-eradicating agents to address the underlying cause of chronic and recurring bacterial infections.

PI_NAMEs: HUIGENS, ROBERT WILLIAM (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Address;Amines;Anti-Bacterial Agents;antibiotic tolerance;Antibiotics;Area;Award;Bacteria;bacterial community;Bacterial Infections;Biological;Biological Process;Biology;Biomedical Engineering;Cell Survival;Cells;Cessation of life;chemical synthesis;Chemicals;Chronic;Complex;cycloaddition;Development;Disease;Engineering;Expeditions;experimental study;Future;Guidelines;halogenation;Health;Human;human disease;Indole Alkaloids;Infection;insight;Investigation;Malaria;Malignant Neoplasms;Microbial Biofilms;natural product inspired;Natural Products;Opiate Addiction;Parents;pathogen;pathogenic bacteria;persistent bacterial infection;Phenazines;Reaction;Recurrence;scaffold;Series;small molecule;Surface;System;Technology;Transcript;United States

PROJECT_TITLE: Indole Alkaloids and Halogenated Phenazines: Platforms for Discovery

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]