NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: DIVIETI PAJEVIC, PAOLA  (contact)

PROJECT_TERMS: Algorithms;Architecture;Biological Assay;Biological Models;bone cell;Cell Culture Techniques;Cell Line;Cell Lineage;Cell model;cell type;Cells;Clinical;Collaborations;computer cluster;Consultations;cost;Data;Data Analyses;data analysis pipeline;design;Development;differentiation protocol;directed differentiation;Education and Outreach;Educational Activities;Educational process of instructing;Educational workshop;Emerging Technologies;Equipment;established cell line;experience;experimental study;gene editing technology;Genes;genetic manipulation;genetically modified cells;hands on instruction;Human;human subject;image translation;improved;In Situ;In Vitro;in vivo;Individual;induced pluripotent stem cell;Infrastructure;innovation;Institution;interest;Joints;Laboratories;Lead;Learning;Libraries;Ligaments;Light;medical schools;member;Mentors;Methods;Microscope;Mission;model organism;Molecular Analysis;Morphology;Multipotent Stem Cells;Mus;Musculoskeletal;Musculoskeletal Development;Musculoskeletal Diseases;Musculoskeletal Manipulations;open source;osteoprogenitor cell;Pathology;Phenotype;pluripotent stem cell differentiation;Population;pre-clinical;Preparation;Price;Process;programs;Protocols documentation;Reagent;reagent testing;Recording of previous events;Research;Research Design;Research Personnel;RNA;RNA library;Sample Size;Sampling;Science;Services;single cell sequencing;single-cell RNA sequencing;skeletal;Specimen;stem cells;Technology;Tendon structure;Tissues;tool;Training;Training and Education;Transcript;transcriptome sequencing;transcriptomic profiling;transcriptomics;working group

PROJECT_TITLE: Cellular and Molecular Analysis Core


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: OMAHA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative: This training program in the fundamentals of biochemistry and molecular biology is designed to equip the next generation of scientists with the skills and basic knowledge that provide the foundation for all modern biomedical science. Key to our mission is to enhance the diversity of our trainees by recruiting and retaining a diverse student body. Students who graduate from this program will be trained in critical thinking, ethical and independent research, and a variety of key skills in biochemistry and molecular biology that will lead to employment in academic and biomedical research in industry, teaching, and a variety of additional science careers.

PI_NAMEs: CAPLAN, STEVEN H (contact);HYDE, RICIA KATHERINE;OBERLEY-DEEGAN, REBECCA E

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TITLE: Fundamental Training Program in Biochemistry and Molecular Biology Research

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The transcriptional history of a cell comprises critical developmental or adaptive ‘decisions’ that have shaped its present state. We aim to capture these past histories on a genome level through the novel approach of transcriptional endpoint marking (TEM), which introduces a permanent genetic mark at the locus of actively transcribed genes. This method will enable us to uncover informative markers of past developmental branch points and drivers of fate decisions.

PI_NAMEs: BREUSS, MARTIN WERNER (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Benchmarking;Biological;biomaterial compatibility;Cell Culture Techniques;Cell Lineage;Cell model;Cells;Chemicals;Chemoresistance;chemotherapy;Collection;computational basis;computerized data processing;Data;Detection;Development;Disease;Dissociation;effective therapy;Event;Gene Combinations;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Genomics;Health;In Vitro;in vivo;Injury;insight;interest;Laboratories;Location;Methods;Modeling;morphogens;Mus;Nature;Neoplasm Metastasis;next generation sequencing;novel;novel strategies;Phenotype;Population;promoter;Proteomics;Recording of previous events;Reporting;resilience;Resistance;response;Retrieval;Retrotransposon;Selection for Treatments;Shapes;single cell technology;Site;System;Techniques;Technology;Testing;Time;Tissues;transcriptome;transcriptomics;transmission process;Transposase;tumor;Work;Zebrafish

PROJECT_TITLE: Genome-wide assessment of transcriptional state history

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NY

PHR: Narrative Systemic lupus erythematosus is a severe autoimmune disease in which antibodies to self- components cause inflammation in many organs. Current therapies for SLE are not effective enough and have many side effects. The focus of the Feinstein Institutes for Medical Research ACE project is to analyze the origins and mechanisms for expansion of the specialized immune cells that arise during flares of disease. These studies may then allow for the proper selection of patients for clinical trials of new treatments that target the relevant pathways to maintain the remission state.

PI_NAMEs: DAVIDSON, ANNE ;DIAMOND, BETTY  (contact)

PROGRAM_OFFICER_NAME: FERGUSON, STACY E

PROJECT_TERMS: Acceleration;Address;Affect;age related;Antibodies;Antigen Presentation;Antigens;Autoantibodies;Autoimmune Diseases;Autoimmunity;Automobile Driving;autoreactive B cell;autoreactivity;B cell reconstitution;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Binding Proteins;Blood;Blood specimen;CD19 gene;Cell Proliferation;Cells;chimeric antigen receptor T cells;Chronic;Chronic Disease;Clinical;clinical infrastructure;Clinical Trials;cohort;Collaborations;Complement;Complication;conditioning;cytokine;Data Analyses;Deposition;design;Development;Diamond;Disease;Disease remission;end stage disease;Ensure;Fibrosis;Flare;Fluorescence;Frequencies;Generations;Geography;Helper-Inducer T-Lymphocyte;HIF1A gene;Histologic;Human;Immune;immune cell infiltrate;Immunologics;Immunosuppression;improved;Individual;Inflammation;Inflammatory;Injury to Kidney;insight;interest;interstitial;Kidney;Knowledge;Label;Lead;Lupus;Lupus Nephritis;Macrophage;Maintenance;Mediating;Medical Research;Medicine;member;Metabolic;Methods;Modeling;monocyte;Mus;Myeloid Cell Activation;Myeloid Cells;new therapeutic target;next generation sequencing;novel;novel therapeutics;Nuclear Antigens;Nucleic Acids;Onset of illness;Organ;Pathogenesis;pathogenic autoantibodies;Pathogenicity;Pathway interactions;Patient Recruitments;Patient Selection;patient stratification;Patients;personalized medicine;Pharmaceutical Preparations;Pilot Projects;Plasma Cells;Plasmablast;Population;Preparation;prevent;Production;programs;progression risk;Property;Quality of life;Reagent;Regimen;Remission Induction;Research Personnel;response;Role;Sampling;Serology;side effect;Stimulus;Stromal Cells;Systemic Lupus Erythematosus;Systemic Therapy;T-Cell Activation;therapy resistant;tissue injury;Tissues;tool;Toxic effect;Underserved Population;uptake;Urine;Woman;Work

PROJECT_TITLE: A mechanistic understanding of B cell and macrophage plasticity in lupus disease activity states

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JTS-I (J1)]


NIH_SPENDING_CATS: Autoimmune Disease;Lupus

PI_NAMEs: DIAMOND, BETTY  (contact)

PROJECT_TERMS: Adherence;age related;Antigen Presentation;Autoimmunity;B-Lymphocytes;biobank;Biometry;Blood;Cells;Clinical;clinical center;Clinical Data;clinical infrastructure;Clinical Investigator;clinical remission;clinical research site;Clinical Trials;cohesion;cohort;Collaborations;Collection;Consultations;Data;data management;data repository;Development;Diamond;Disease;Disease remission;disorder risk;Ensure;experience;Flare;Goals;high risk;Home;Immune;Individual;Infiltration;Inflammatory;Institution;Institutional Review Boards;Kidney;Longitudinal Studies;Lupus;Macrophage;Manuscripts;Medical Research;meetings;member;Myeloid Cell Activation;Myeloid Cells;novel therapeutics;Pathogenesis;Patient Recruitments;Patient Selection;Patients;Pilot Projects;prevent;Principal Investigator;Process;programs;Progress Reports;Prospective cohort;Protocols documentation;recruit;Research;Research Personnel;Research Project Grants;Rheumatology;Risk;Role;Sampling;Schedule;Specimen;Systemic Lupus Erythematosus;T-Cell Activation;Technology;Time;translational study;Urine;Work

PROJECT_TITLE: Administrative Core


PROJECT_TERMS: Abnormal Cell;Antibodies;Antigenic Specificity;Antigens;antimicrobial;Apoptotic;Autoimmune Diseases;autoreactive B cell;B cell differentiation;B-Cell Acute Lymphoblastic Leukemia;B-Cell Antigen Receptor;B-Lymphocyte Subsets;B-Lymphocytes;Cell Culture Techniques;Cell Physiology;Cells;Characteristics;clinical remission;cohort;design;Disease;Disease remission;disorder control;DNA;ds-DNA;Enzyme-Linked Immunosorbent Assay;experience;Flow Cytometry;Frequencies;Gene Expression Profile;high throughput analysis;Histones;Immunity;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin M;Immunoglobulin Switch Recombination;Immunoglobulin-Secreting Cells;Immunoglobulins;Individual;inflammatory milieu;Lupus;Macrophage;Mediating;Memory;Memory B-Lymphocyte;Methodology;Methods;novel;Nuclear Antigens;Pathogenicity;Patients;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Plasmablast;Predisposition;Property;Proteins;Reaction;Receptor Activation;Regulation;release of sequestered calcium ion into cytoplasm;response;single-cell RNA sequencing;Specificity;systemic inflammatory response;Systemic Lupus Erythematosus;T-Lymphocyte;Therapeutic;Therapeutic Intervention;Toll-like receptors

PROJECT_TITLE: Principal Project-Characterization of ANA+ and ANA-B cells in individuals with SLE and healthy subjects


PI_NAMEs: KIM, SUN JUNG  (contact)

PROJECT_TERMS: Ablation;Address;Affect;age related;Agonist;Amino Acids;Antigen Presentation;Antigen-Presenting Cells;Antigens;Antioxidants;Autoantibodies;Autoimmune;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;belimumab;BLR1 gene;case finding;Cathepsins;CD4 Positive T Lymphocytes;CD80 gene;Cell Physiology;Cell secretion;Cells;chemokine receptor;cohort;Complement 3d Receptors;Complex;congenic;cytokine;Data;Development;differentiation in vitro;Disease;effector T cell;Environmental Risk Factor;Etiology;Exhibits;Flare;Gene Expression;Generations;Genes;Genetic;Genetic study;Genetic Transcription;Glucose;glucose uptake;Glycolysis;HIF1A gene;Homeostasis;Inflammasome;Inflammation;Inflammatory;Infrastructure;Ingestion;inhibitor;Interleukin-1 beta;Interleukin-10;Interleukin-6;ITGAX gene;knock-down;Knowledge;Laboratories;Lupus;Lupus Nephritis;lupus prone mice;Macrophage;Mediating;Memory B-Lymphocyte;Metabolic;metabolome;Metformin;Mitochondria;Modeling;Mus;Myeloid Cells;Names;Nuclear Antigens;Organ;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Pilot Projects;Pinocytosis;Population;Prevention;Process;Production;response;risk variant;Role;Sampling;Signal Transduction;single cell analysis;systemic autoimmune disease;Systemic Lupus Erythematosus;T cell differentiation;T-bet protein;T-Cell Activation;T-Cell Receptor;Testing;Therapeutic Monoclonal Antibodies;TLR7 gene;transcriptomics;uptake

PROJECT_TITLE: Pilot Project-Characterization of antigen presentation by ABCs


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Recent discoveries have been made about immune cells which are part of the underlying mechanism that drives an autoimmune disease that exhibits "fibrosis" or scarring of tissues. New knowledge about the immune cells that likely drive this disease may allow the development of new treatments for autoimmunity.

PI_NAMEs: PILLAI, SHIV SUBRAMANIAM (contact)

PROJECT_TERMS: adaptive immune response;Affect;Amphiregulin;Antigens;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;B cell therapy;B-Lymphocytes;Biological Assay;Blood;Categories;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cicatrix;Clonal Expansion;cohort;Collaborations;Color;cross reactivity;cytotoxic;Cytotoxic T-Lymphocytes;Development;Disease;Disease Progression;Disease remission;Distant;draining lymph node;Enzyme-Linked Immunosorbent Assay;Event;Exhibits;Feces;Fibrosis;follow-up;Goals;Granzyme;Human;IgG4-related disease;Image;Immune;Immune response;Immune System Diseases;Immunoglobulin G;Immunoprecipitation;Individual;individual patient;Indolent;Induction of Apoptosis;Infiltration;Inflammation;Inflammatory;insight;Knowledge;Life;Link;Luciferases;Maintenance;Maps;Memory;microbial;microbiome;microbiome signature;microorganism antigen;Molecular;Molecular Analysis;Nature;novel;novel therapeutic intervention;Onset of illness;Organ;Output;Pathway interactions;Patients;Peptides;Peripheral Blood Mononuclear Cell;Pilot Projects;Population;Protein Array;receptor;Recurrence;Relapse;repaired;response;Serum;Shapes;Signal Pathway;Signal Transduction;System;Systemic Scleroderma;Systems Biology;T cell response;T memory cell;T-Lymphocyte;Time;Tissue imaging;Tissues;tool;transcriptomics;Transforming Growth Factor beta

PROJECT_TITLE: An autoimmune center of excellence for the study of IgG4-related disease


NIH_SPENDING_CATS: Autoimmune Disease

PROJECT_TERMS: Autoimmune;Autoimmune Diseases;Autoimmunity;Cells;Characteristics;Chromatin;Code;Collaborations;Communities;Country;Data;data sharing;Databases;Disease;Ensure;Equipment and supply inventories;Fruit;General Hospitals;Goals;Hospitals;Hour;Human;IgG4-related disease;Immune;Immunology;interest;Location;Massachusetts;Mediating;meetings;member;Michigan;microbial community;next generation sequencing;Patients;Pilot Projects;Principal Investigator;programs;Research;Research Personnel;Resources;sample collection;Sampling;Site;Techniques;Time;Tissues;tool;working group


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research

PROJECT_TERMS: Amphiregulin;Annexins;Antigens;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;B-Cell Acute Lymphoblastic Leukemia;B-Lymphocyte Subsets;B-Lymphocytes;Biological Assay;Blood;Categories;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;Cell Compartmentation;Cells;Clinical;Clonal Expansion;cohort;Collaborations;cytotoxic;Cytotoxic T-Lymphocytes;Diagnosis;Disease;Disease remission;draining lymph node;Enzyme-Linked Immunosorbent Assay;Event;Fibrosis;Flow Cytometry;Granzyme;gut microbiome;Helper-Inducer T-Lymphocyte;high dimensionality;Human;IgG4;IgG4-related disease;Immune;Immune System Diseases;Immunoglobulin G;Immunoprecipitation;Individual;Indolent;Infiltration;Inflammation;Inflammatory;insight;Label;Link;Luciferases;Maintenance;Memory B-Lymphocyte;memory CD4 T lymphocyte;Nature;Organ;Patients;Peptides;Peripheral;Phenotype;Protein Array;Proteins;Recurrent disease;Relapse;Remission Induction;response;restoration;screening;secondary lymphoid organ;senescence associated secretory phenotype;Serology;Source;Specificity;Study models;System;Systems Biology;T cell infiltration;T-Lymphocyte;Time;Tissue imaging;Tissues;transcriptomics;Transforming Growth Factor beta;V(D)J Recombination

PROJECT_TITLE: Principal Project


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Rare Diseases;Scleroderma

PI_NAMEs: XAVIER, RAMNIK J (contact)

PROJECT_TERMS: Address;Antigen Presentation;Antigen Targeting;antigen-specific T cells;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;Automobile Driving;autoreactive T cell;B-Lymphocytes;CD4 Positive T Lymphocytes;Clonal Expansion;Collaborations;computerized tools;cytotoxic;Disease;disease classification;Dominant Genetic Conditions;Etiology;Exhibits;experience;Extracellular Matrix;Fibrosis;Flare;genetic risk factor;IgG4-related disease;Immunity;immunogenic;immunogenicity;Immunologic Monitoring;Inflammation Mediators;Inflammatory;Inflammatory Bowel Diseases;Interleukin-10;Longitudinal Studies;Metagenomics;Microbe;microbial;microbiome;microbiome analysis;microbiome signature;microorganism antigen;molecular phenotype;Pathogenesis;Pathogenicity;Pathologic;Patients;Peptides;Phenotype;Play;Production;Profibrotic signal;Property;response;Role;Self Tolerance;Severe Acute Respiratory Syndrome;Specificity;Systemic Scleroderma;T cell response;T-Lymphocyte;T-Lymphocyte Epitopes;Technology;Tissues;virtual

PROJECT_TITLE: Collaborative Project


ADMINISTERING_IC: AR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: INDIANAPOLIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE Musculoskeletal disease and disorders affect 1 out of 2 Americans and continue to contribute the majority of physician/ hospital visits and medical costs. It is necessary to develop new approaches for prevention and therapies. The establishment of the ICMH Basic Science Resource Center (ICMH-BSRC) will provide the resources required by individual investigators and teams of investigators to accelerate progress towards understanding and treating musculoskeletal disease.

PI_NAMEs: ROBLING, ALEXANDER G (contact)

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: 3-Dimensional;Acceleration;Accounting;Address;Affect;Aging;aging population;American;Animals;Antibodies;Area;Autocrine Communication;Basic Science;bench-to-bedside translation;Biology;bioprinting;Body System;bone;bone cell;bone fracture repair;Budgets;Cancer Cachexia;Cartilage;Cells;Chronic Disease;Clinical;clinical application;Clinical Research;Collaborations;college;Communication;Complex;Connective Tissue;Consultations;Core Facility;cost;Data Analyses;data integration;data management;Data Set;Dedications;Development;Diabetes Mellitus;disability;Disease;Disparity population;Education;Endocrine;Engineering;Environmental Risk Factor;experience;experimental study;Facility Designs;Faculty;Familial hypophosphatemic bone disease;Fortification;Future;Genetic;Genomics;Goals;graduate student;Grant;Growth;Health;Health Care Visit;Health Resources;high school;High School Student;Histologic;Histology;Hospitals;In Vitro;in vivo;Indiana;Individual;innovation;Institution;International;Investments;Kidney Diseases;Knowledge;Lead;Link;Liquid substance;Liver diseases;Malignant neoplasm of liver;Measurement;Measures;Mechanics;mechanotransduction;Medical Care Costs;medical schools;meetings;member;Metabolic;metabolomics;Minority Groups;Modality;Modeling;Molecular;Movement;multiple omics;Muscle;Muscle Cells;Musculoskeletal;Musculoskeletal Diseases;musculoskeletal injury;Musculoskeletal System;next generation;novel;novel strategies;nutrition;Obesity;operation;Organ;Osteocytes;Osteoporosis;outreach;Periodontal Diseases;Physical Function;Physicians;Postdoctoral Fellow;Prevention approach;Process;Productivity;programs;Proliferating;Property;Research;Research Design;Research Personnel;Resources;Role;sarcopenia;Schools;Science;Scientist;Service delivery model;Services;social determinants;Statistical Models;structural health determinants;synergism;System;Systemic disease;Systems Biology;Techniques;Technology;Tissues;tool;Training;Training and Education;translational approach;Translations;Traumatic Arthropathy;vibration;Visit;Work

PROJECT_TITLE: Resource Cores for Musculoskeletal Biology Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 FY (M1)]


PROJECT_TERMS: Accounting;Address;Affect;Age;Area;arm;Awareness;Basic Science;Biology;Biomedical Engineering;bone;Budgets;Cartilage;Clinical;clinical translation;Collaborations;Collection;Communication;Communities;Consultations;cost;Country;Data;data management;Dedications;design;Disease;Education;Ensure;Environment;experimental study;Focus Groups;Fortification;Fostering;Funding;Future;Grant;Growth;Health;High Prevalence;high school;High School Student;Indiana;Infrastructure;innovation;innovative technologies;Institute of Medicine (U.S.);Institution;investigator training;Investments;large datasets;Lead;Length;Measurement;meetings;Methodology;mindfulness;Mission;Monitor;multiple omics;Muscle;Musculoskeletal;Musculoskeletal Diseases;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Needs Assessment;next generation;Outcome Measure;outreach;Persons;Pilot Projects;Productivity;programs;Reproducibility;Research;Research Activity;Research Design;Research Infrastructure;Research Personnel;Research Support;Resources;Science;Scientist;Services;Source;Statistical Methods;Student recruitment;synergism;Systems Biology;Techniques;Technology;Therapeutic;Tissues;Traction;Training Programs;Translational Research;undergraduate student;Underrepresented Minority;United States;Universities;Update;Work


PI_NAMEs: ALLEN, MATTHEW R (contact)

PROJECT_TERMS: Aging;analytical method;Area;Basic Science;Biological;Biology;bone;bone quality;career;Cartilage;Cells;Clinical assessments;Collaborations;Communities;Complex;Consultations;cost effectiveness;Country;Data;Data Analyses;data quality;Decalcification;Development;Disease;disease model;Ecosystem;Ensure;Equipment;experience;experimental study;Faculty;Frozen Sections;Funding;Future;graduate student;Health;Histologic;Histological Techniques;Histology;Human Resources;Immunohistochemistry;improved;Indiana;innovation;interest;Intervertebral disc structure;Laboratories;Ligaments;Measurement;Measures;Mechanics;Methodology;Modality;Modeling;multiple omics;Muscle;Musculoskeletal;Musculoskeletal Development;Musculoskeletal Diseases;Musculoskeletal System;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Osteocytes;Outcome;Outcome Assessment;pharmacologic;Physiological;Play;pre-clinical assessment;Preparation;Procedures;programs;Protocols documentation;Quality Control;recruit;Regulation;Reproducibility;Research;Research Design;Research Personnel;Resources;response;Role;Services;skeletal;skeletal tissue;Stains;Standardization;Surveys;Systems Biology;Techniques;Tendon structure;Tissues;Training;Training and Education;Training Programs;transcriptomics;Universities;Work

PROJECT_TITLE: Histology and Histomorphometry Core (HHC)


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LIU, YUNLONG  (contact)

PROJECT_TERMS: Address;Big Data;Bioinformatics;Biological;Biological Assay;biological preparation;Biology;bone;Cancer Biology;Cardiovascular Diseases;Cells;Center Core Grants;Chromatin Structure;Collaborations;Collection;Communities;Computational Biology;Computer software;computerized data processing;course introduction;course module;Custom;Data;Data Analyses;data dissemination;data integration;Data Set;data standards;design;Development;Disease;Education;Educational workshop;Environment;experimental study;Gene Expression Profile;Generations;Genomics;Goals;Group Meetings;Health;Human Resources;Indiana;Infrastructure;innovation;insight;Institution;Knowledge;large datasets;Ligaments;Mass Fragmentography;mass spectrometer;Mass Spectrum Analysis;Measurement;Medical center;medical schools;member;Metabolic;metabolomics;Methodology;Methods;mineralization;Mission;Molecular;Molecular Biology;multiple omics;Musculoskeletal;Nervous System Disorder;new technology;novel;Nuclear Magnetic Resonance;open source;Osteoblasts;Osteoclasts;Osteocytes;Post-Translational Protein Processing;Probability;Production;programs;protein expression;Proteins;Protocols documentation;Research;Research Design;Research Personnel;Resources;Sampling;Science;Services;single cell sequencing;Skeletal Muscle;stable isotope;Standardization;System;Systems Biology;Technology;Tendon structure;Testing;therapeutic evaluation;tool;Tracer;Training;training opportunity;Universities;working group

PROJECT_TITLE: Systems Biology and Multi-Omics Core (SBMO)


NIH_SPENDING_CATS: Bioengineering;Rehabilitation

PROJECT_TERMS: Address;Aging;Animal Genetics;Animal Model;Animals;Area;autocrine;Automobile Driving;Awareness;Biological;Biology;Bolus Infusion;bone;bone cell;Botox;Cell Line;Cells;chemical standard;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Core Facility;Culture Techniques;Dedications;Dentistry;Development;Discipline;Disease;Education and Outreach;Electric Stimulation;Endocrinology;Energy consumption;Engineering;Environment;Equipment;Exercise;experience;experimental study;fluid flow;Future;Genetic;Goals;Health;Hormonal;Hormones;Immobilization;In Vitro;in vivo;Indiana;Individual;Infrastructure;Injury;innovation;instrumentation;Joints;Leadership;Maintenance;mechanical drive;mechanical signal;Mechanical Stimulation;mechanical stimulus;Mechanics;mechanotransduction;Modeling;Muscle;Muscle Cells;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal System;Mutant Strains Mice;Mutation;next generation;operation;Orthopedics;Osteocytes;outreach;paracrine;Paralysed;Pharmaceutical Preparations;pharmacologic;Physical therapy;Process;Productivity;programs;recruit;Regulation;Research;Research Personnel;Resources;response;scaffold;Services;Signal Transduction;skeletal;Skeletal Muscle;Source;Standardization;Tail Suspension;Techniques;Technology;Testing;theories;tibia;Tissues;tool;Training;Training and Education;Transfection;treadmill;vibration;Work

PROJECT_TITLE: Musculoskeletal Mechanobiology Core (MMBC)


ORG_CITY: ANN ARBOR

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE With the shift in biomedical research towards big data and data-driven strategies, a major challenge is to robustly translate the vast amount of information generated into meaningful biological insights and clinically relevant information. The overall goal of the University of Michigan SBDRC is to leverage our strengths in genomic editing, bioinformatics, and mouse modeling to enable a rapid transition from discovery to function and to address biologic and disease context, as well as facilitating the development of appropriate state-of-the-art in silico and in vivo disease models. The key objective for UM-SBDRC is to accelerate ongoing skin research toward new discoveries and ultimately benefit a wide range of patients with cutaneous disorders.

PI_NAMEs: GUDJONSSON, JOHANN ELI (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;Advisory Committees;Animal Model;ATAC-seq;Award;Basic Science;Big Data;Bioinformatics;Biological;Biology;Biomedical Research;Breeding;Cell Culture Techniques;Cell Line;Cells;Clinic;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Communities;Consultations;CRISPR/Cas technology;Cutaneous;cytokine;Data;Data Analyses;data analysis pipeline;Data Set;data warehouse;Derivation procedure;Dermatologist;design;Development;Discipline;Disease;disease model;Effectiveness;Ensure;Epigenetic Process;epigenome;epigenome editing;established cell line;Evaluation;experience;experimental analysis;Experimental Designs;Fees;Fibrosis;Fostering;gene induction;Generations;Genes;Genetic;Genetic Screening;Genetically Engineered Mouse;genome editing;genome-wide;genomic data;Goals;Grant;Hair follicle structure;in silico;in vivo;Inflammation;Infrastructure;innovation;insight;Institution;keratinocyte;Knock-in;Knock-out;Leadership;member;Mentors;Mentorship;Michigan;Mission;Modeling;Modification;mouse model;Mutagenesis;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Neoplasms;Nuclear RNA;operation;Patients;Periodicals;Personnel Management;Phenotype;Primary Cell Cultures;Production;programs;Protocols documentation;Publications;Quality Control;query tools;Recording of previous events;Research;Research Infrastructure;Research Personnel;Resources;RNA;Schools;screening;searchable database;Series;service delivery;Services;single cell ATAC-seq;Skin;skin disorder;Speed;Structure;success;symposium;System;Systems Biology;tool;Training;training opportunity;transcriptomics;Transgenes;Translating;translational impact;Translational Research;Translations;Travel;ultraviolet irradiation;United States;Universities;Validation;Visit;Widespread Disease;Work

PROJECT_TITLE: University of Michigan Skin Biology and Diseases Resource-based Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 KM (M1)]


PROJECT_TERMS: Address;Advisory Committees;Animal Model;Award;Bioinformatics;Biological;Biology;Cell Line;Clinic;Clinical and Translational Science Awards;Collaborations;Communication;Communities;Cutaneous;Databases;Dedications;Dermatology;Development;Discipline;Disease;disease model;Effectiveness;electronic bulletin board;Electronic Mail;Electronics;Ensure;Environment;equity, diversity, and inclusion;Evaluation;faculty mentor;Fee-for-Service Plans;Feedback;Fostering;Funding;Future;Genes;genome editing;Goals;Grant;Health;improved;in silico;in vivo;Individual;Infrastructure;innovation;Institution;International;Leadership;medical schools;meetings;member;Mentors;Michigan;Mission;mouse model;multidisciplinary;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Newsletter;Newspapers;Office of Administrative Management;Online Systems;operation;Patients;Peer Review;posters;Printing;programs;Publications;Research;Research Activity;Research Infrastructure;Research Personnel;Resources;Review Committee;Scholars Program;Science;Series;Services;Skin;skin disorder;Structure;success;Surveys;symposium;synergism;System;Training;Translating;Travel;Universities;University adminstration;University resources;Update;Visit;visiting scholar;web site


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PROJECT_TERMS: Acceleration;APOCEC3G gene;ATAC-seq;Base Sequence;Basic Science;bioinformatics resource;Biological;Biology;Cell Nucleus;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Consultations;CRISPR/Cas technology;Cutaneous;cytokine;Data;Data Analyses;data analysis pipeline;data integration;Data Set;data sharing;data to knowledge;Databases;design;differential expression;Disease;Effectiveness;Epigenetic Process;epigenome;epigenome editing;epigenomics;Ethnic Origin;experience;Experimental Designs;Female;Funding;Gene Expression;Generations;Genes;Genetic Engineering;Genetic Screening;genome editing;genome wide association study;genome-wide;genomic data;Genomics;Genotype-Tissue Expression Project;Goals;high throughput screening;Immune;In Situ;Inflammatory;Infrastructure;innovation;insight;keratinocyte;Knock-in;Knock-out;male;Massachusetts;Mediating;member;Michigan;Mission;Modification;Molecular;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Non-Neoplastic Skin Disorder;novel;Paper;PF4 Gene;Phenotype;Plasmids;prevent;Productivity;Reporter;Research;Research Personnel;Resources;RNA;Services;Skin;skin disorder;statistics;Systems Biology;Techniques;Technology;tool;Training;Training and Education;training opportunity;Transcript;transcription factor;transcriptomics;Transfection;Translational Research;United States National Institutes of Health;Universities;Washington;web interface;Widespread Disease;XCL1 gene

PROJECT_TITLE: Functional Analytics Core


NIH_SPENDING_CATS: Biotechnology;Genetics

PI_NAMEs: DLUGOSZ, ANDRZEJ A. (contact)

PROJECT_TERMS: Address;Age;Allografting;Animal Model;Animals;Back;Biochemical;Biological Assay;Biology;Breeding;Cell Culture Techniques;Cell Line;cell type;clinically relevant;Collaborations;Collection;Complex;Consultations;cost;design;Development;Disease;disease model;Doxycycline;Embryo;Fibrosis;Future;Gender;gene induction;Genes;Genetically Engineered Mouse;genomic locus;Genotype;Goals;Grant;Hair;Histologic;Human Biology;human disease;in vivo;Individual;inducible Cre;Inflammation;innovation;insight;Institution;Instruction;interest;Investments;Knowledge;loss of function;member;Michigan;Mission;model development;Modeling;Molecular;mouse model;Mus;mutant;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel therapeutics;Organism;Pathogenesis;Pathologic;Phase;Phenotype;Physiological;pre-clinical;preclinical study;Primary Cell Cultures;Procedures;Production;Protocols documentation;Publications;repository;Reproducibility;Reproducibility of Results;Research;Research Personnel;Resource Sharing;Resources;response;screening;Service delivery model;Services;Site;Skin;skin disorder;Standardization;Technical Expertise;Technology;Testing;Time;Tissue Banks;Tissues;tool;Training;transgene expression;Transgenes;Transgenic Mice;Transgenic Organisms;ultraviolet irradiation;Universities;Validation;Vendor;Work;Xenograft procedure

PROJECT_TITLE: Animal Modeling Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Cardiovascular;Hypertension;Kidney Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MEMPHIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Project Narrative  The prevalence of hypertension increases with age. The purpose of the proposed research is to determine the role of renal stem cell-derived exosomes in aging-related kidney dysfunction and hypertension. Completion of the project may offer a new preventive and therapeutic approach for aging-associated kidney dysfunction and hypertension which will benefit the US population.

PI_NAMEs: SUN, ZHONGJIE  (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: Address;Affect;Age;aged;Aging;aging mechanism;aging population;aging related;Attenuated;Binding;Blood Pressure;Cardiovascular Diseases;Cell Physiology;Chronic Kidney Failure;Development;Disease;Down-Regulation;effective intervention;Elderly;Endosomes;Environment;Excretory function;exosome;Extracellular Space;gerotherapeutic;High Prevalence;Hypertension;Impairment;in vivo;Incidence;Inflammatory Response;innovation;insight;Kidney;kidney dysfunction;kidney vascular structure;Maintenance;Membrane Lipids;Molecular;Mus;nanoscale;novel;novel therapeutic intervention;old mice;paracrine;Pathogenesis;Population;Positioning Attribute;Prevalence;Preventive;preventive intervention;Regulation;Renal function;Research;Role;salt sensitive hypertension;Sodium Chloride;stem cell exosomes;symporter;Testing;Therapeutic;Therapeutic Intervention;Time;Tubular formation;Up-Regulation;Vesicle;Work

PROJECT_TITLE: Regulation of kidney function and blood pressure in aging

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Parent grant “Reducing Avoidable Nursing Home-to-Hospital Transfers of Residents with ADRD: An Analysis of Interdisciplinary Team Communication using Text Messages” (1R01AG078281-01) In this project we examine how interdisciplinary communication using text messaging can improve delivery of age-friendly care to NH residents and prevent avoidably NH-to-hospital transfer. This study will provide information needed for the development and testing of interventions using convenient, low-cost technologies, like text messaging, to ultimately reduce morbidity and mortality in residents with ADRD.

PI_NAMEs: POWELL, KIMBERLY RYAN (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Age;Alzheimer's disease related dementia;Caring;Communication;Communication Methods;Complex;cost;Cost Control;Data Set;Decision Making;Development;Documentation;Electronics;Elements;Emotional;evidence base;Expenditure;Friends;Health;Health system;high risk;Hospitalization;Hospitals;Impaired cognition;improved;Individual;Interdisciplinary Communication;Intervention;Language;Medical Care Team;Medicare/Medicaid;member;Modernization;Morbidity - disease rate;mortality;Natural Language Processing;novel;Nursing Homes;older adult;parent grant;Pathway Analysis;Patients;Pattern;Pharmaceutical Preparations;Population;portability;prevent;Process;Quality of Care;satisfaction;Social Network;Stress;Structure;Technology;Telefacsimile;Telephone;Testing;Text Messaging;Thinking;transmission process;Work


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: IOWA CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative University of Iowa researchers use flow cytometry and microscopy to study human diseases or their associated therapies, such as prostate and breast cancer, multiple myeloma, lymphoma, cancer metastasis, autoimmune disease, immunotherapy, neurodegenerative disease, influenza, SARS/COVID infection, cellular effects of PCB pollutants, and stem cell therapies. The cells that hold the key to understanding and treating these diseases are often present in minuscule numbers and cannot be readily examined with both technologies in the same experiment, which necessitates the acquisition of an imaging cytometer to ensure these unique cell populations can be quantitatively and qualitatively examined concurrently. Ensuring University of Iowa investigators are equipped with state-of-the-art instrumentation to perform these studies will enable advances in our understanding of human health and disease and allow us to uncover therapeutic avenues to treat adverse conditions.

PI_NAMEs: BALLAS, ZUHAIR K. (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: Address;Basic Science;Biological;Biological Process;Biomedical Research;Cells;Cellular Morphology;Clinical Trials;college;Consumption;cost;Data;data acquisition;Disease;Ensure;experimental study;Flow Cytometry;Funding;Goals;Health;Human;Image;improved;instrument;instrumentation;Iowa;Label;Methods;Microscope;Microscopy;Morphology;novel;Population;pre-clinical;Principal Investigator;protein protein interaction;Reproducibility;Request for Proposals;Research;Research Personnel;Research Project Grants;Rest;Running;Sampling;Scheme;single cell sequencing;Stains;Technology;Time;United States National Institutes of Health;Universities;Variant;Work

PROJECT_TITLE: Imaging Cytometer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-D (30)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Complementary and Integrative Health;Mental Health;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Disorders of the nervous system inflict staggering costs to our society across the lifespan, highlighting a major need to train the next generation of neuroscientists. The NBIO program at UNC-CH has provided graduate- level training in neuroscience research for the past 57 years, and our trainees have advanced to careers in academia, industry, and other science-related fields. This predoctoral training grant prepares NBIO graduate students to discover new principles and knowledge of brain function, information that is needed to develop novel treatments for a diversity of brain disorders and diseases.

PI_NAMEs: SONG, JUAN ;ZYLKA, MARK J. (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Neurosciences;pre-doctoral;Training

PROJECT_TITLE: Neuroscience Predoctoral Training at UNC-Chapel Hill

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (03)]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Exposure to trauma can lead to premature cognitive decline, as early as mid-life, and adversely affect people quality of life. First responders who were 20-35 years old at the time of September 11 terror attack, are at a greater risk for premature cognitive decline, especially if they have other health consequences such as respiratory disorders or depression. This proposal aims to assess cognitive decline, using a battery of neuropsychological tests and neuroimaging measures, to advance our understanding of premature cognitive decline and its neurobiological mechanisms among the youngest first responders that will contribute to the development of early interventions.

PI_NAMEs: CYCOWICZ, YAEL M (contact)

PROJECT_TITLE: Neuropsychological Profile and Neurocognitive Biomarkers of Attention and Memory in Trauma-Exposed Responders at Risk of Premature Cognitive Decline


ORG_CITY: STONY BROOK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PI_NAMEs: SCHWARTZ, HANSEN ANDREW (contact)

PROJECT_TITLE: Developing and Evaluating Artificial Intelligence-based Longitudinal Assessments of PTSD in 9/11 Responders


ADMINISTERING_IC: PS

IC_NAME: NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STD AND TB PREVENTION

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Men who have sex with men (MSM), especially young Black and Latino MSM, have the highest rates of HIV diagnoses in the United States. The goal of the proposed Type II Hybrid Study is to improve pre-exposure prophylaxis screening, counseling, initiation, adherence, and persistence in young Black and Latino MSM in two high-priority settings.

PI_NAMEs: SCHNALL, REBECCA  (contact)

PROJECT_TITLE: RFA-PS-21-003: PrEP Choice: Increasing the Use of HIV Pre-exposure Prophylaxis in an Era of Choices


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Major recent transformations in health care financing and delivery within and outside of the Department of Veterans Affairs (VA) are now presenting Veterans with unprecedented health care choices. These choices give Veterans opportunities to make decisions about their use of VA and non-VA health care that optimize the timeliness, affordability, quality, and patient-centeredness of their care. However, these decisions also carry great potential for unintended consequences if they are not well-informed. Despite such high stakes, little is known about how Veterans are currently making decisions about using VA and non-VA health care, what information they want to use in this decision-making, and how the provision of information to Veterans about their health care options could be improved. This research will examine how Veterans are now making decisions about using VA and non-VA health care and identify promising new strategies to better support Veterans in making well-informed, personalized decisions about their VA and non-VA health care options.

PI_NAMEs: KULLGREN, JEFFREY  (contact)

PROJECT_TERMS: Acceleration;care preference;Caring;Characteristics;Communities;Community Healthcare;Community Networks;Complex;Decision Making;Deductibles;design;Eligibility Determination;Evolution;experience;Focus Groups;Geography;Health;health care cost/financing;health care service;health care settings;health plan;Healthcare;Healthcare Systems;improved;innovation;insight;Interview;Learning;Low income;Measures;Medicaid;Methodology;Methods;Participant;patient oriented;patient population;Perception;personalized decision;Policies;Policy Analysis;Privatization;Process;programs;Provider;public health insurance;Qualitative Methods;Reporting;Research;Resource Allocation;Sampling;Science;Services;Source;Statutes and Laws;Structure;success;Surveys;System;Translations;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Optimizing Veteran Decision-Making About Use of VA and Non-VA Health Care

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative This project will develop general-purpose, scalable, and open-source statistical shape modeling (SSM) tools, which will present unique capabilities for automated anatomy modeling with less user input. The proposed tech- nology will introduce a number of signiﬁcant improvements to current SSM approaches and tools, including the support for challenging modeling problems, inferring shapes directly from images (and hence bypassing the seg- mentation step), parallel optimizations for speed, and new user interfaces that will be much easier and scalable than the current tools. The proposed technology will constitute an indispensable resource for the biomedical and clinical communities that will enable new avenues for biomedical research and clinical investigations, provide new ways to answer biologically related questions, allow new types of questions to be asked, and open the door for the integration of SSM with clinical care.

PI_NAMEs: ELHABIAN, SHIREEN YOUSSEF (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Adoption;algorithm development;Algorithms;anatomic imaging;Anatomic Models;Anatomic Surface;Anatomy;Area;base;Biological;Biological Process;Biological Sciences;Biological Testing;Biology;Biomedical Research;biomedical resource;Brain;Bypass;Cardiology;Cessation of life;Clinical;clinical care;Clinical Data;clinical investigation;clinically relevant;Cloud Computing;cohort;Collection;Communities;Complex;Complex Analysis;Computational Technique;Computer Models;computer scientist;Computer software;computerized tools;computing resources;Custom;Data;Databases;deep learning;Development;Disease;experience;flexibility;Funding;Generations;Geometry;global health;Goals;graphical user interface;Human;Image;image archival system;image processing;Imagery;imaging Segmentation;improved;in vivo imaging;Injury;innovation;Intuition;Laboratory Research;large datasets;Learning;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Mathematics;Measures;Medical;Medicine;Mission;Modeling;Modernization;Modification;Morphogenesis;multidisciplinary;National Institute of General Medical Sciences;Occupations;Online Systems;open source;Organism;Orthopedics;particle;Pathologic;Population;preference;Reproducibility;Research;Research Personnel;Resolution;Science;Scientist;Shapes;Site;software development;Software Engineering;Software Tools;Specialist;Speed;Statistical Data Interpretation;Structure;Supervision;Surface;Techniques;Technology;Time;tool;training data;usability;user-friendly;Variant;Visual;Visualization software

PROJECT_TITLE: Anatomy Directly from Imagery: General-purpose, Scalable, and Open-source Machine Learning Approaches

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ORG_CITY: TEMPLE

ORG_NAME: OLIN TEAGUE VETERANS CENTER

ORG_STATE: TX

PHR: VA has been aggressively hiring additional staff to improve mental health access and working to improve productivity, but productivity measures do not reveal what sequences of care might affect capacity. We propose to use a data science method, sequence analysis, to determine whether we can use VA administrative data to measure reliable sequences of mental health care. We focus on sequences of mental health services following a new diagnosis of depression because depression is highly prevalent, and a new diagnosis is likely to initiate a new sequence of care. Our long-term objective is to implement sequence analysis measures to help managers and clinicians identify whether patients are engaged in a sequence of care that is associated with positive or negative outcomes.

PI_NAMEs: BENZER, JUSTIN K. (contact)

PROJECT_TERMS: administrative database;Affect;anti-depressive agents;Area;Attention;Base Sequence;Brief Psychotherapy;care coordination;care fragmentation;Caring;Clinical;cohort;Collaborations;Communication;comorbidity;Consensus;Consult;Continuity of Patient Care;cost;Data;Data Science;data warehouse;Diagnosis;Dimensions;discrete time;Distal;DNA Sequence;Ensure;Event;experience;Feedback;Follow-Up Studies;Frequencies;Funding;Goals;health care delivery;Health care facility;health care service;health service use;Health Services;Health system;Healthcare Systems;Improve Access;improved;Incentives;Infrastructure;innovation;Intake;integrated care;Intervention;Interview;Leadership;Learning;Location;Measures;Medical center;Mental Depression;Mental Health;Mental Health Services;mental representation;Methodology;Methods;multidisciplinary;Newly Diagnosed;Outcome;Output;patient engagement;Patient-Focused Outcomes;Patients;Pattern;Patterns of Care;Performance;Periodicals;Pharmaceutical Preparations;Policies;Primary Care;primary care setting;Procedures;Process;Productivity;Provider;Psychotherapy;Quality of Care;Records;Reporting;Research Personnel;Resource Allocation;Resources;Sampling;satisfaction;Savings;Sequence Analysis;Services;Social Work;Surveys;Symptoms;System;Testing;Time;Veterans;Visit;wasting;Work

PROJECT_TITLE: Validating a data science methodology for patterns of mental health services use: The patient record of clinical experience sequence study (PROCESS)

STUDY_SECTION_NAME: HSR-3 Healthcare Informatics[HSR3]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PUBLIC HEALTH NARRATIVE Antiretroviral therapies are the medications used to treat HIV infection and help people with HIV to lead longer and healthier lives. However, people on those therapies still have difficulties with mental abilities such as learning, memory, and concentration. To better understand how HIV affects the brain and leads to these difficulties, we will perform multiple brain scans and tests of mental abilities over time in a group of individuals with HIV who are participating in two of the largest ongoing HIV studies in the U.S.

PI_NAMEs: MAKI, PAULINE M;RUBIN, LEAH HELANE (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Address;Affect;Anterior;antiretroviral therapy;Area;Attention;Behavior;behavior measurement;Behavioral;Binding;blood oxygen level dependent;Brain;brain circuitry;Brain Injuries;Brain scan;Cells;Chronic;cingulate cortex;Cognitive;cognitive control;Cognitive deficits;cognitive performance;cognitive testing;Cognitive Therapy;cohort;Cohort Studies;comorbidity;Corpus striatum structure;Cross-Sectional Studies;Data;Development;Diffusion Magnetic Resonance Imaging;Dimensions;Emotional;Event;executive function;Functional disorder;Functional Magnetic Resonance Imaging;Funding;glial activation;Goals;Heterogeneity;Hippocampus;HIV;HIV Infections;HIV therapy;HIV-associated neurocognitive disorder;Immunologics;Impairment;Individual;innovation;Intervention;Lateral;Lead;Learning;Link;longitudinal analysis;longitudinal design;Longitudinal Studies;Macrophage;Magnetic Resonance Imaging;mathematical model;Measures;Medial;Mediating;Memory;Mental Tests;Modality;monocyte;Motor Cortex;multidisciplinary;Multimodal Imaging;National Institute of Mental Health;neural circuit;Neurocognitive Deficit;neuroimaging;neuroimaging marker;Neuroimmune;neuroinflammation;Neurologic;neuromechanism;neurotoxic;novel;Parietal Lobe;Participant;Pattern;Performance;Persons;Pharmaceutical Preparations;Phenotype;Plasma;Positron-Emission Tomography;precision medicine;Prefrontal Cortex;Process;processing speed;Proteins;Psyche structure;Public Health;Reporting;Reproducibility;Research Domain Criteria;Research Priority;response;Rest;RNA I;Services;Short-Term Memory;Site;stem;Subgroup;System;Testing;The Multicenter AIDS Cohort Study;Time;United States National Institutes of Health;verbal;Verbal Learning;Viral;Viral Proteins;Virus;Virus Shedding;Woman;Women's Interagency HIV Study

PROJECT_TITLE: Neural mechanisms of HIV-associated CNS dysfunction despite viral suppression

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Richter’s syndrome (RS) is a critical complication of chronic lymphocytic leukemia (CLL) patients, and a barrier to CLL management, with patients exhibiting refractoriness to most existing therapies and a median overall survival of ~12 months. The evolutionary trajectories and biological mechanisms leading to RS development from the antecedent CLL are largely unknown, because of the relative rarity of primary RS samples and the limited availability of genetically-engineered mouse models. The objective of these studies is to dissect pathogenic mechanisms of RS in human genetics-inspired mouse models, to identify disease-specific oncogenic circuitries and targetable vulnerabilities, and to test a panel of drugs pre-clinically to provide the basis for tailored therapeutic interventions.

PI_NAMEs: TEN HACKEN, ELISA  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Acceleration;Address;Agammaglobulinaemia tyrosine kinase;Apoptotic;Award;B-Lymphocytes;BCL2 gene;Bioinformatics;Biological;Biological Assay;Biology;Biometry;Bromodomain;cancer cell;career development;CD19 gene;CDKN2A gene;Cell model;cell type;Characteristics;chemotherapy;ChIP-seq;chromosome 13q loss;Chronic Lymphocytic Leukemia;Clinical;Clinical Management;Clonal Evolution;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Communication;Complication;Computational Biology;CRISPR/Cas technology;Data;Data Set;Dependence;design;Development;Development Plans;Diffuse;Disease;disease model;DNMT3a;efficacy evaluation;Engineering;Enhancers;EP300 gene;Epigenetic Process;Exhibits;EZH2 gene;Family;Flow Cytometry;Fostering;functional genomics;Gene Mutation;Generations;Genes;Genetic;genetic architecture;Genetic Engineering;genetic makeup;Genetic Transcription;Genetically Engineered Mouse;Genome;genomic locus;Genomics;Genotype;Grant;Hematologic Neoplasms;Hematopoietic stem cells;Histology;Human;human disease;Human Genetics;Immunology;improved;In Vitro;in vivo;in vivo evaluation;Individual;inhibitor;insight;interest;International;Knock-in;large cell Diffuse non-Hodgkin's lymphoma;Leadership;Lesion;leukemic transformation;Link;loss of function;loss of function mutation;Malignant lymphoid neoplasm;Malignant Neoplasms;Manuscripts;Mediation;Methylation;Modeling;Molecular;molecular modeling;mouse model;Mus;Mutation;Myeloproliferative disease;Natural History;NOTCH1 gene;novel;Oncogenic;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacology;Phenotype;Postdoctoral Fellow;pre-clinical;preclinical study;Preclinical Testing;programs;Proteins;Recurrence;Refractory;Reporting;Research;Richter's Syndrome;Sampling;Signal Transduction;skills;symposium;System;targeted agent;Testing;Therapeutic;Therapeutic Intervention;tool;TP53 gene;Training;transcriptome;transcriptome sequencing;Translational Research;Transplantation;treatment strategy;Tumor Suppressor Proteins;Tyrosine Kinase Inhibitor;Up-Regulation;Validation;Work;Writing;XCL1 gene;Yin

PROJECT_TITLE: Defining the epigenetic landscape and therapeutic vulnerabilities of Richter's syndrome in CRISPR-based mouse models


NIH_SPENDING_CATS: Aging;Atherosclerosis;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Neurosciences;Prevention;Stroke

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: The proposed study is relevant to public health because narrowing of brain arteries is one of the most common causes of stroke worldwide. Compelling evidence suggests novel antithrombotic medications could reduce the rate of stroke in patients with narrowed brain arteries. The proposed study will directly compare novel antithrombotic medications to standard care antiplatelet medications for preventing stroke and death from vascular causes in patients with narrowed brain arteries. The study will incorporate the NINDS Common Data Elements.

PI_NAMEs: CHIMOWITZ, MARC IVOR;HOH, BRIAN LIM (contact)

PROGRAM_OFFICER_NAME: AFZAL, MARIAM MASHEEB

PROJECT_TERMS: Address;antagonist;Anticoagulants;Anticoagulation;Antiplatelet Drugs;arm;Arterial Fatty Streak;Arteries;Aspirin;Atherosclerosis;Blood Platelets;Blood Vessels;Brain;Carotid Stenosis;carrier status;Cerebral hemisphere hemorrhage;Cerebrovascular Disorders;Cessation of life;China;Chinese;Clinical Trials;clopidogrel;Common Data Element;Control Groups;Coronary;Coronary Arteriosclerosis;CYP2C19 gene;Cytochrome P450;Data;design;Disease;Disease Progression;disorder risk;Dose;Double-Blind Method;effective therapy;Enzymes;Event;experimental arm;Fatality rate;Fibrinolytic Agents;follow-up;Generations;Genetic;Genetic Polymorphism;hazard;Heart failure;Hemorrhage;high risk;improved outcome;Infarction;Infrastructure;innovation;interest;Intracranial Hemorrhages;Ischemia;Ischemic Stroke;loss of function;Medical;Minor;National Institute of Neurological Disorders and Stroke;novel;Nucleotides;Oral;Patients;Peripheral;Pharmaceutical Preparations;Phase;Platelet Activation;prevent;primary endpoint;Prognosis;prospective;Protocols documentation;Public Health;Qualifying;Randomized;randomized trial;receptor;Recurrence;Regimen;Risk;Risk Factors;Risk Reduction;Site;standard care;Stenosis;Stents;Stroke;Stroke prevention;stroke risk;three-arm clinical trial;Thrombin;thrombotic

PROJECT_TITLE: Comparison of Anti-coagulation and anti-Platelet Therapies for Intracranial Vascular Atherostenosis


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) frequently co- occur, and having both disorders is associated with greater psychological and functional impairment than having either disorder alone. The most effective PTSD treatment, prolonged exposure (PE) is less effective when individuals also have AUD. Anti-relapse medication appears promising to improve the effectiveness of PE to help individuals reduce alcohol use and PTSD symptoms and improve functioning. This study compares PE with and without topiramate, a medication shown to both reduce drinking and PTSD symptoms, with the hypothesis that combined PE and topiramate will be more effective than PE and placebo. The aim of this grant is to improve treatment outcomes for Veterans with AUD and PTSD.

PI_NAMEs: NORMAN, SONYA  (contact)

PROJECT_TERMS: active method;Aftercare;Alcohol abuse;alcohol comorbidity;Alcohol consumption;alcohol craving;alcohol use disorder;associated symptom;Caring;clinical practice;Clinical Practice Guideline;cognitive function;depressive symptoms;design;Disease;Distress;Double-Blind Method;drinking;Drops;effective therapy;Effectiveness;efficacy trial;evidence base;Evidence based treatment;Exhibits;Female;follow-up;Functional impairment;functional improvement;Goals;Grant;Guidelines;Heavy Drinking;Impairment;improved;Individual;innovation;Intervention;Lead;male;Mediating;Methodology;military veteran;novel;Participant;Patients;Pharmaceutical Preparations;pharmacologic;Placebos;Post-Traumatic Stress Disorders;psychologic;Psychotherapy;Quality of life;Randomized;Recovery;reduce symptoms;reduced alcohol use;Relapse;Research;Research Design;Sampling;Services;standard care;sustained recovery;Symptoms;Testing;topiramate;treatment comparison;treatment guidelines;Treatment outcome;Veterans

PROJECT_TITLE: Combining Topiramate and Prolonged Exposure for PTSD and Alcohol Use Disorder

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


NIH_SPENDING_CATS: Genetics

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE This grant supports research training for primarily MD & MD/PhD, and secondarily PhD trainees enrolled in the Department of Molecular and Human Genetics ABMGG residency and fellowship programs at Baylor College of Medicine. It has a long tradition of training current and future leaders in medical genetics research.

PI_NAMEs: LEE, BRENDAN  (contact)

PROJECT_TERMS: Fellowship Program;Genetic Research;Medical Genetics

PROJECT_TITLE: Medical Genetics Research Fellowship Program


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Data Science

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Global proteomics mass spectrometry data sharing infrastructure – Project Narrative Mass spectrometry based proteomics is a key technology for the identification and quantification of proteins in many types of biological samples, which can be used to determine how abundances of proteins are affected by perturbed cellular systems under stress or the cause of a disease. We propose a substantial advancement of proteomics mass spectrometry data repository resources to enable researchers to share, find, access, and reuse proteomics datasets at a global scale.

PI_NAMEs: BANDEIRA, NUNO  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Acceleration;Address;Adopted;Affect;Aging;Authorization documentation;Biological;Certification;Clinical;Communities;Data;data access;Data Files;data handling;data infrastructure;data portal;Data Reporting;data repository;Data Science;Data Set;data sharing;data submission;Deposition;design;Detection;differential expression;Disease;Ensure;expectation;Experimental Designs;FAIR principles;file format;Funding Agency;Generations;Goals;Health Insurance Portability and Accountability Act;Human;human data;human subject;improved;indexing;Infrastructure;instrumentation;Internet;Journals;Mass Spectrum Analysis;Measures;member;Metadata;Modernization;open data;Paper;Peptides;Policies;Post-Translational Protein Processing;Procedures;Process;protein complex;Protein Isoforms;Proteins;Proteome;Proteomics;Publishing;Reporting;repository;Research Personnel;Resources;Risk;Sampling;Secure;Security;shared repository;Staging;Standardization;Stress;Structure;System;Technology;technology development;Testing;therapeutic development;treatment response;Variant;web services

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)S]


NIH_SPENDING_CATS: Aging;Obesity

ORG_DEPT: PATHOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: This project focuses on a newly recognized function of a unique population of regulatory T cells (Tregs) that resides in visceral adipose tissue (VAT) of lean, but not obese, mice and humans, and is capable of reining in both inflammation and metabolic dysfunction and, thereby, protecting against type-2 diabetes, cardiovascular diseases and certain cancers. We demonstrate that VAT Tregs regulate the dynamics of local adipogenesis by directly controlling the differentiation of stroma-associated adipocyte precursor cells, and study the molecular underpinnings of this function, its age-dependence and its sexual dimorphism. Obesity and its downstream comorbidities are major health challenges of the 21st century -- specifically enhancing the representation or activity of VAT Tregs offers a potential alternative to current frontline insulin-sensitizing drugs, whose side-effects have sometimes elicited concern.

PI_NAMEs: MATHIS, DIANE J (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Ablation;Address;adipocyte differentiation;Adipocytes;Adipose tissue;Age;age effect;age related;Aging;Autoimmunity;Biological Assay;Cardiovascular Diseases;Cell Compartmentation;Cells;Collaborations;Communication;comorbidity;Data;Dependence;Deposition;dimorphism;experimental group;Explosion;Female;Fibrosis;FOXP3 gene;Genetic Transcription;Goals;Growth;head-to-head comparison;Health;Homeostasis;Human;Hypersensitivity;Immune response;Immunologics;In Vitro;in vivo;in vivo evaluation;Inflammation;insulin sensitivity;insulin sensitizing drugs;lipid biosynthesis;Literature;lymphoid organ;male;Malignant Neoplasms;Mediator;mesenchymal stromal cell;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Microbe;Molecular;Mus;Natural regeneration;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;old mice;oncostatin M;Phenotype;Population;Poverty;PPAR gamma;precursor cell;Process;Production;programs;receptor;Regulatory T-Lymphocyte;Reporting;response;Rodent;sex;sexual dimorphism;side effect;stem cells;T-cell receptor repertoire;Testing;Thinness;Tissues;transcriptome;transcriptomics;tumor;Visceral

PROJECT_TITLE: Adipose-tissue Tregs: important players in immunological control of metabolism

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_NAME: KALOCYTE, INC.

PHR: Project Narrative There is a need for an artificial oxygen carrier to care for patients in settings where banked human blood is unavailable or undesirable. To address this need, we have developed ‘ErythroMer’ (EM), a first-in-class bio- synthetic, nano-cyte, blood substitute. The goals of this project are to conduct IND enabling studies of EM, comprising: Detailed non-GLP pharmacokinetic, biodistribution metabolism and excretion studies with exploratory toxicology, GLP hemocompatibility, GLP-safety pharmacology and GLP expanded acute dose toxicology studies to determine starting doses of EM in an initial clinical trial.

PI_NAMEs: ALP, ESMA  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acute;Address;Adverse effects;Affinity;analytical method;animal data;Animal Model;Animals;Antioxidants;arm;Authorization documentation;Behavior;Biodistribution;Biological;biomaterial compatibility;Biomedical Engineering;Biotechnology;Blood;Blood Substitutes;Blood Vessels;Body Weight;Canis familiaris;Cardiac Electrophysiologic Techniques;Caring;Cell Physiology;Clinical;Clinical Chemistry;Clinical Trials;Coagulation Process;commercialization;Complement Activation;Complex;Containment;Control Animal;cost effective;Cytokine Activation;design;Development;Development Plans;Diffusion;Dose;Drug Kinetics;Drug or chemical Tissue Distribution;Elements;Emergency Situation;Ensure;Erythrocytes;Evaluation;Evolution;Excretory function;expectation;experimental study;Failure;Feedback;first-in-human;Fluorocarbons;food consumption;Freeze Drying;Gases;Goals;good laboratory practice;Hematology;hemocompatibility;hemodynamics;Hemoglobin;Hemolysis;Hemorrhage;Human;Hybrids;In Vitro;Individual;innovation;Kidney;Leukocytes;Life;Lipids;Lung;manufacturing scale-up;Marketing;Medical Device;Metabolic;Metabolism;method development;Microscopic;Morphology;Multiple Trauma;nano;nanomaterials;nanoparticle;Natural Immunity;New Zealand;Nitric Oxide;novel;novel therapeutics;Nucleosome Core Particle;Organ Weight;Oryctolagus cuniculus;oxidation;Oxygen;particle;Particle Size;Pathology;Pathway interactions;Patient Care;Pharmacologic Substance;Pharmacology;Pharmacology Study;Pharmacy (field);Phase;Phase I Clinical Trials;Physiological;Plasma;Platelet Activation;point of care;portability;pre-clinical;preclinical evaluation;preclinical safety;preclinical study;prevent;Process;Production;Productivity;Qualifying;Recommendation;reconstitution;Recovery;Research;Risk;Rodent;RSR-13;Safety;safety practice;safety study;self assembly;serial imaging;Shapes;Signal Transduction;Site;stem cells;Sterility;Surface;Testing;Tissues;Toxic effect;Toxicokinetics;Toxicology;Transfusion;trial design;Update;Validation;Vasospasm

PROJECT_TITLE: ErythroMer: Nanoscale BioSynthetic Red Cell Substitute


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Social behaviors in humans and other animals are dynamically regulated by steroid hormones such as androgens (e.g., testosterone); however, the effects androgens have on the brain are unclear. The proposed research will use the highly social cichlid fish Astatotilapia burtoni to study how androgens regulate genetic and neurobiological mechanisms in the brain. Given that all vertebrates have androgens and similar genes and neurons that regulate social behavior, the mechanisms identified by this work can be studied further in other organisms, including humans.

PI_NAMEs: ALWARD, BEAU  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Androgen Receptor;Androgens;Animal Model;Animals;Behavior;Behavior Control;Behavioral;Brain;brain control;Brain imaging;Cichlids;Complex;CRISPR/Cas technology;Data;Evolution;Exhibits;experimental study;Female;gene editing technology;Gene Expression;Genes;Genetic;Hormonal;Human;infancy;innovation;Knowledge;Laboratories;Link;male;mutant;neurobiological mechanism;Neuronal Plasticity;Neurons;novel;Organism;Partner in relationship;Physiological;Physiology;Positioning Attribute;Process;programs;receptor;Research;Research Personnel;response;Role;single cell genomics;Site;social;Social Behavior;Social Controls;Social Environment;Social Hierarchy;Social Interaction;Social status;steroid hormone;System;Techniques;Testis;Testosterone;trait;Vertebrates;Work

PROJECT_TITLE: Steroid hormone dependent gene expression and neuroplasticity in the brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Substance Misuse;Women's Health Research

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Given increasing rates of cannabis use, the development and evaluation of new treatments for adults with cannabis use disorder (CUD) is crucial. Reduction in cannabis use may be a viable alternative goal to abstinence, but the amount of reduction necessary to achieve remission of CUD is unknown. This proposal addresses key gaps in CUD trials by determining gender-specific “lower-risk” cannabis use associated with successful CUD remission during an 8-week course of computerized cognitive-behavioral therapy and examining the role of the sex hormone, progesterone, in successful cannabis reduction.

PI_NAMEs: MCRAE-CLARK, AIMEE L;TOMKO, RACHEL LYNN (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Abstinence;addiction;Address;Adopted;Adult;Age;alcohol use disorder;Attenuated;Behavior;Behavioral;Benchmarking;Biological;Cannabis;cannabis use behavior;Clinical;Clinical Research;Clinical Treatment;Clinical Trials;clinically relevant;Cocaine;computerized;Computerized Cognitive Behavioral Therapy;Development;diaries;Disease remission;drug sensitivity;Drug usage;effective therapy;Electronics;Empirical Research;Enrollment;Evaluation;Female;follow-up;Frequencies;Future;Gender;gender difference;Goals;Gonadal Steroid Hormones;Individual;Intervention;Literature;marijuana legalization;marijuana use;marijuana use disorder;men;Mental disorders;milligram;mobile application;Natural Increases;Online Systems;Outcome;Ovarian hormone;Participant;Patient Preferences;Patient Self-Report;Pattern;Persons;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Play;pre-clinical research;Prevalence;Progesterone;psychiatric comorbidity;psychosocial;Risk;Role;saliva sample;sample collection;Sampling;Self Assessment;sex;Sex Differences;sex variable;social;Standardization;Substance Use Disorder;Symptoms;Testing;Tetrahydrocannabinol;Therapeutic;therapy development;Tobacco;treatment duration;Treatment outcome;treatment program;treatment research;urinary;Variant;Video Recording;Visit;Withdrawal;Woman;women's treatment;Work

PROJECT_TITLE: Gender and Sex Hormone Influences on Cannabis Use Disorder Remission


PHR: Project Narrative Our studies will reveal key features that are central to gene regulation. We will reveal the rules by which a family of protein complexes called SWI/SNF regulates the expression of specific genes. Our results will explain many important unanswered questions about SWI/SNF in human diseases, which may offer new avenues to control gene expression for new therapies.

PI_NAMEs: HODGES, HAMILTON COURTNEY (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Biology;Cells;Chemicals;Chromatin;chromatin remodeling;Complex;Disease;DNA;Epigenetic Process;epigenomics;Family;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic manipulation;Genetic Transcription;Genome;genome-wide;Heterogeneity;human disease;improved;Intervention;live cell microscopy;Mammals;Microscopy;novel therapeutics;Outcome Measure;Permeability;Process;protein complex;Protein Family;Role;Signal Transduction;Site;Specificity;Technology;tool;Variant

PROJECT_TITLE: Determinants of genome-wide activity and specificity of SWI/SNF family chromatin remodeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Bioengineering;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: Hepatitis C virus (HCV) is a hepatotropic virus that establishes chronic infection in ~70% of those exposed. While effective direct acting antiviral (DAA) therapeutic combinations are highly potent, we are not yet on track to achieve the WHO goal of elimination by 2030, which will require a scaling-up of HCV screening, linkage-to-care, reduction of treatment cost as well as advancing our understanding HCV persistence and drug resistance. Importantly, because viral cell-to-cell spread has been implicated in antiviral escape, immune escape, and persistence of viruses in general, the insights gained through the proposed HCV studies should broadly inform future antiviral strategies for hepatitis C and related viruses.

PI_NAMEs: PERELSON, ALAN S;UPRICHARD, SUSAN L. (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Accounting;Address;Anti-viral Agents;Anti-viral resistance;Anti-viral Therapy;Award;Biological;Biological Process;Caring;Cell Culture Techniques;Cells;Chronic;chronic infection;Cirrhosis;Clinical;clinically relevant;combat;cost;Data;design;Development;drug efficacy;Drug resistance;Drug Synergism;Drug Targeting;Ebola;Effectiveness;emerging virus;experience;extracellular;Fatty Liver;Fibrosis;Fostering;Funding;Future;Goals;Grant;HCV Cirrhosis;HCV screening;Hepatitis C;Hepatitis C Therapy;Hepatitis C virus;Hepatocyte;high risk population;Immune;improved;in silico;In Vitro;in vivo;Individual;individualized medicine;Infection;Inflammation;inhibitor;insight;Insulin Resistance;Interferons;kinetic model;Knowledge;Life Cycle Stages;Liver diseases;Maintenance;mathematical model;Mathematics;Measures;Methods;Modeling;Molecular;Molecular Virology;multi-scale modeling;Patients;Persons;Pharmaceutical Preparations;Play;Population;prevent;Primary carcinoma of the liver cells;Public Health;Quantitative Evaluations;Request for Applications;Risk;RNA replication;RNA Viruses;Role;scale up;Serum;Severe Acute Respiratory Syndrome;System;Testing;Therapeutic;therapy duration;Time;tool;Treatment Cost;treatment effect;Treatment Efficacy;treatment response;United States;Variant;Viral;viral resistance;viral RNA;Virus;Work

PROJECT_TITLE: Collaborative Integration of HCV Molecular Virology and Mathematical Modeling

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE The goal of this project is to compare and evaluate the 3D STAIR-UTE direct myelin imaging technique and the SyMRI indirect myelin imaging technique for evaluation of myelin damage in AD. We will conduct studies using biological myelin phantoms, human brain specimens from donors without and with AD, and a cross-sectional study of healthy volunteers and patients with mild cognitive impairment (MCI) and AD, to validate novel quantitative MRI techniques for detection of myelin quantity and quality. This fellowship will conduct a systematic comparison between 3D STAIR-UTE and SyMRI in depicting myelin changes for both ex vivo samples and in vivo controls and patients, thereby facilitating advancement of new diagnostic approaches for AD.

PI_NAMEs: ATHERTYA, JIYO S (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: 3-Dimensional;absorption;Action Potentials;Affect;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Axonal Transport;Biological;Brain;Brain imaging;Cadaver;career;Child;Child Development;Clinical;Clinical dementia rating scale;cognitive function;cognitive testing;cohort;commercialization;Complex;Cross-Sectional Studies;data acquisition;Dementia;Demyelinations;Deposition;design;Detection;detection method;Development;Diagnosis;diagnostic strategy;disability;Disease;Disease Progression;Edema;Evaluation;Event;extracellular;Fellowship;Funding;Generations;Goals;Grant;gray matter;healthy volunteer;Histology;Human;Image;Imaging Techniques;Impaired cognition;Impairment;improved;in vivo;in vivo imaging;Inflammation;Iron;Learning;Magnetic Resonance Imaging;Maintenance;Maps;Measures;Mechanics;mental state;Mentors;mild cognitive impairment;Monitor;Motor Skills;Myelin;Nerve Degeneration;Neurofibrillary Tangles;non-invasive imaging;novel;novel diagnostics;Oligodendroglia;Participant;Pathogenesis;Patients;Physiologic pulse;Play;Powder dose form;Pregnant Women;prevent;Productivity;Protocols documentation;Protons;Recovery;Reference Standards;Refractory;Registries;Relaxation;Research;Role;Sampling;Senile Plaques;Sensitivity and Specificity;Signal Transduction;simulation;Specimen;Speed;Suspensions;Techniques;Time;Tissues;Training;Translational Research;transmission process;Vendor;Vesicle;Water;white matter

PROJECT_TITLE: Comparison of direct and indirect magnetic resonance imaging of myelin in Alzheimer's disease


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: This training program trains predoctoral and postdoctoral fellows in multiple disciplines and state-of-the-art technologies. The intent is to elucidate biological mechanisms that form the basis of diseases, including cancer, that arise as a consequence of exposure to diverse environmental agents. The goal of this training program is to produce leaders in academia, the biotechnology and pharmaceutical industries and regulatory agencies who have the experience and knowledge to understand and make informed decisions in the environmental health sciences.

PI_NAMEs: MILLER, WILLIAM E (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TITLE: Environmental Carcinogenesis and Mutagenesis

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Obesity;Patient Safety;Physical Activity;Prevention

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: PROJECT NARRATIVE Patients with colon cancer who require chemotherapy dose reductions and treatment delays are twice as likely to experience disease recurrence and death. This study will determine the optimal dose of aerobic exercise that improves chemotherapy tolerability and is behaviorally feasible for colon cancer survivors.

PI_NAMEs: BROWN, JUSTIN C (contact);CAAN, BETTE J;MEYERHARDT, JEFFREY A

PROGRAM_OFFICER_NAME: TESAURO, GINA M

PROJECT_TERMS: Adherence;Adverse event;Aerobic Exercise;attentional control;behavior change;Behavioral;Biological Markers;Biological Response Modifiers;Body Composition;Body fat;Boston;Calibration;cancer care;Cancer Survivor;Caring;Certification;Cessation of life;Chemotaxis;chemotherapy;Clinical;Clinical Practice Guideline;Colon Carcinoma;Common Terminology Criteria for Adverse Events;Complex;Counseling;Data;Dose;Dose Limiting;Drug Kinetics;Drug or chemical Tissue Distribution;Dual-Energy X-Ray Absorptiometry;Elastases;evidence base;Exercise;exercise adherence;exercise physiologist;exercise prescription;exercise training;experience;Fatty acid glycerol esters;gastrointestinal;Geographic Locations;Guidelines;heart rate monitor;Histone H3;Home;immune function;Immune system;Impairment;improved;Incidence;Intervention;Malignant Neoplasms;Measures;Muscle;muscle form;Neutropenia;neutrophil;novel;Obesity;Participant;patient oriented;Patient Outcomes Assessments;Patients;Peripheral Nervous System Diseases;Peroxidases;Pharmaceutical Preparations;Phenotype;Physiological;preservation;primary endpoint;Probability;Race;Randomized;Recommendation;recruit;Recurrent disease;Reporting;Research Design;Respiratory Burst;response;Risk;sarcopenic obesity;secondary endpoint;Severities;socioeconomics;Stretching;Supportive care;Symptoms;synergism;Techniques;Telephone;Thinness;Time;Tissues;Toxic effect;Toxicity due to chemotherapy;Translating;treadmill;Variant;video chat

PROJECT_TITLE: Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer


ORG_DEPT: CHEMISTRY

PHR: PROJECT NARRATIVE: The proposed research is relevant to public health because it helps identify the roles played by small molecular changes in DNA and RNA bases, often occurring in non-Watson-Crick structures, that reside in parts of human or viral genomes regulating gene expression. Methods developed here will aid our ability to sequence genomes, not just for the four common letters A, C, G and T/U, but also for some of the rare but significant base modifications that impact mutations, epigenetics, and viral activity.

PI_NAMEs: BURROWS, CYNTHIA J (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: base;Biochemical;Biological;biophysical techniques;Cells;Chemicals;Chemistry;Cockayne Syndrome;Detection;DNA;DNA Repair Gene;endonuclease;endonuclease VIII;Enzymes;Epigenetic Process;Future;G-Quartets;Gene Expression;Gene Expression Regulation;Genes;Genome;Guanine;Guanine Nucleotides;Human Genome;Individual;Inflammatory;Letters;Methods;Modification;Molecular;Mutation;nanopore;Nucleic Acid Regulatory Sequences;Nucleotides;Outcome;oxidation;Oxidative Stress;Play;programs;promoter;Proteins;Pseudouridine;Public Health;Research;RNA;Role;Stress;Structure;transcriptome;United States National Institutes of Health;Viral Genome;Viral Physiology;Virus Diseases;Work;Writing

PROJECT_TITLE: Chemical Modifications in Regulatory Regions of DNA and RNA

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: PITTSBURGH

ORG_STATE: PA

PHR: The Veterans’ Choice Program and MISSION Act have transformed how the Department of Veterans Affairs (VA) delivers care by expanding Veterans’ eligibility to receive VA-funded care from community providers. However, there is limited evidence about how this major structural change has affected the quality and equity of health care for Veterans, or their satisfaction with care. Given the challenges of coordinating care between VA and community providers, medically and socially vulnerable Veterans may be at particular risk for adverse outcomes from care fragmentation, underscoring a need to examine the impact of these changes on equity. Our study will use innovative analytic methods to examine the effects of these programs on the quality and equity of outpatient care and prescribing in Veterans. We will also examine how patient experiences with community care differ among vulnerable Veterans. This project will provide VA with critical evidence for guiding ongoing implementation of the MISSION Act and efforts to improve community care for vulnerable Veterans.

PI_NAMEs: GELLAD, WALID F. (contact);ROBERTS, ERIC T

PROJECT_TERMS: Address;Admission activity;Adverse effects;adverse outcome;Affect;Ambulatory Care;analytical method;Attention;Automobile Driving;care coordination;care fragmentation;care recipients;Caring;Clinical;Communities;Community Healthcare;complex chronic conditions;Continuity of Patient Care;Data;data tools;data warehouse;design;Dimensions;Disparity;Drug Interactions;econometrics;Eligibility Determination;Equitable healthcare;Equity;ethnic minority;ethnic minority status;experience;follow-up;Funding;Health;health care cost/financing;health care delivery;health care quality;Health Care Surveys;health equity;Health Services Accessibility;Health system;Healthcare;Hospitalization;Improve Access;improved;innovation;Length of Stay;Link;Low income;Managed Care;Medical;medical vulnerability;Medicare;Methodology;Methods;military veteran;Natural experiment;Outcome;Outpatients;patient safety;Patients;Pharmaceutical Preparations;pharmacy benefit;Policies;Process;Process Measure;programs;Provider;provider communication;Qualitative Research;Quasi-experiment;racial minority;Recommendation;Reporting;Research;Research Priority;Risk;Safety;satisfaction;Services;severe mental illness;social;social vulnerability;Subgroup;Substance Use Disorder;Support Groups;Support System;Surveys;System;Testing;Therapeutic;Time;Translating;Travel;United States Department of Veterans Affairs;Variant;Veterans;Veterans Health Administration;Vulnerable Populations;Work

PROJECT_TITLE: Leveraging a natural experiment to identify the effects of VA community care programs on health care quality, equity, and Veteran experiences

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Women who inject drugs are among the most vulnerable to acquiring HIV, but very few women who inject drugs are prescribed pre-exposure prophylaxis (PrEP) for HIV prevention largely due to barriers within our healthcare system. This research will consider the perspectives of women who inject drugs, healthcare providers, and clinic leadership to improve the way primary care and reproductive health clinics deliver PrEP to women who inject drugs, thereby reducing new HIV infections in this population. The research and training in this application will prepare the candidate for an independent scientific career conducting intervention research among vulnerable populations with high capacity for real-world implementation and dissemination.

PI_NAMEs: STARBIRD, LAURA  (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Appointment;Area;Behavior;behavior change;Behavioral;care delivery;career;career development;Caring;Child Care;Clinic;Clinical;Communities;Community Healthcare;comorbidity;cost;Dedications;design;Development Plans;disparities in women;Dissemination and Implementation;Drug Prescriptions;economic implication;Effectiveness;efficacy evaluation;Epidemic;Equipment;Ethics;evidence base;Evidence based intervention;Evidence based practice;experience;Feedback;Foundations;Future;Gender;gender disparity;Goals;healing;Health;health care delivery;health care service organization;health care service utilization;health care settings;health disparity;Health Personnel;Health Services;Healthcare;Healthcare Systems;Hearing;Helping to End Addiction Long-term;high risk population;HIV;HIV Infections;HIV Seronegativity;HIV/HCV;Hour;Hybrids;implementation intervention;implementation science;improved;Incidence;Individual;Infrastructure;Injecting drug user;Intervention;Intervention Studies;Intervention Trial;Interview;Investments;Knowledge;Leadership;marginalized population;men;Mentored Research Scientist Development Award;Mentors;Mentorship;National Institute of Drug Abuse;Needle Sharing;New York;operation;Organizational Change;Parameter Estimation;Patient Preferences;Pattern;Persons;Pharmaceutical Preparations;pilot test;Population;Populations at Risk;Positioning Attribute;pre-exposure prophylaxis;preference;Pregnancy;prevent;preventive intervention;Primary Care;primary care setting;Property;Provider;Psychiatric Social Work;Psychometrics;Readiness;Recommendation;recruit;Reporting;Reproductive Health;Research;research and development;Research Personnel;Resources;response;responsible research conduct;Risk;Safety;Science;Services;sex;Sexual Health;Site;skills;social stigma;Stretching;Structure;Substance Use Disorder;Surveys;System;Training;United States;Unsafe Sex;uptake;Vulnerable Populations;Walking;Woman

PROJECT_TITLE: Implementation of PrEP for Women Who Inject Drugs through Practice Facilitation in Primary and Reproductive Health Care

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Despite an increased risk of developing Alzheimer’s disease and related dementias (ADRD), African Americans underutilize hospice services, often opting for aggressive end-of-life care and are more likely to die in hospitals than non-Hispanic Whites. Though reasons for hospice underutilization are multifactorial, the sources of hospice information for older African Americans living with ADRD and their primary family caregivers have not been widely explored. This study aims to identify the sources and characteristics of hospice information in older African Americans living with ADRD and their caregivers and to determine the influence of information sources on hospice-decision making.

PI_NAMEs: MILLER, EMIKA S. (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Address;Adult;Affect;African American;African American population;Age Years;Alzheimer's disease related dementia;Attention;Attitude;Awareness;care recipients;career;Caregivers;Caring;Cessation of life;Characteristics;cognitive ability;Collection;Communities;community based research;coronavirus pandemic;cost;Decision Making;design;Development;Device or Instrument Development;Disease;Disparity;Effectiveness;end of life;end of life care;ethnic minority;experience;Family Caregiver;family influence;Fellowship;Foundations;Frequencies;functional decline;Future;Health;Health behavior;Health Care Costs;health disparity;health equity;health equity promotion;health inequalities;Health Information National Trends Survey;Health Personnel;hospice environment;hospice utilization;Hospitals;human old age (65+);Impaired cognition;improved;instrument;Intervention;Interview;Knowledge;Life;Measures;Medical;National Institute of Nursing Research;Not Hispanic or Latino;Nurses;older adult;Oncology;Patients;perceived discrimination;Perception;Persons;Philosophy;Population;Process;Qualitative Methods;Qualitative Research;Quality of life;racial disparity;racial minority;Research;Research Personnel;Research Training;Risk;Sampling;Sampling Studies;Scientific Advances and Accomplishments;Scientist;Services;Signal Transduction;skill acquisition;skills;social health determinants;Social Network;Source;Strategic Planning;Structure;Surveys;Training;trend;trustworthiness;United States;Vulnerable Populations;willingness

PROJECT_TITLE: Hospice exposure and utilization among older African Americans with ADRD and their decisional support persons


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Nanotechnology;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Project Narrative Despite progress in treating primary tumors, metastatic disease to common sites including bone remains incurable. Inhibition of Gli2 using the bone targeted Gli2 inhibitor (GANT58), BT- GANT58-NPs, has shown promise for reducing tumor-associated bone destruction in 3 independent bone metastatic mouse models. In this application we propose particle modifications to improve tumor killing and further reduce bone destruction to work towards a clinically translatable formulation for use in patients with bone metastatic disease.

PI_NAMEs: DUVALL, CRAIG LEWIS;RHOADES (STERLING), JULIE A (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Academic Medical Centers;Acrylates;Affect;Alendronate;Allografting;antagonist;Biodistribution;Biological Availability;Biology;Biomedical Engineering;bisphosphonate;bone;Bone Density;Bone Diseases;Bone Marrow;Bone necrosis;Bone neoplasms;Bone Pain;Bone Resorption;Breast;Breast Cancer Cell;Cancer Biology;Cancer Model;cancer stem cell;Cell model;Chemistry;Chemoresistance;chemotherapy;Clinical;clinical translation;clinically relevant;Collecting Cell;cooking;Data;design;Development;Disease;Disseminated Malignant Neoplasm;Dose;Dose Limiting;drug candidate;drug efficacy;Drug Kinetics;Drug Screening;effective therapy;efficacy evaluation;efficacy study;Ensure;Equilibrium;experience;Family;Formulation;Fracture;Generations;Genetic;Glycols;Goals;Grant;Growth;Growth Factor;Hematology;Histopathology;Homeostasis;Human;Hydrophobicity;Hypercalcemia;Immunocompetent;improved;in vivo;inhibitor;intravenous administration;intravenous injection;Jaw;Kinetics;Lead;Ligand Binding;Liver;Location;Malignant Breast Neoplasm;Malignant neoplasm of lung;Maximum Tolerated Dose;Medicine;Metastatic breast cancer;Metastatic Neoplasm to the Bone;metastatic process;Methods;Micrometastasis;Modeling;Modification;Morbidity - disease rate;mouse model;nanoparticle;Neoplasm Metastasis;neoplastic cell;nephrotoxicity;novel;novel therapeutics;Oncology;Osteoblasts;Osteoclasts;Paclitaxel;Pain;parathyroid hormone-related protein;particle;Patient-Focused Outcomes;Patients;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacology;Polymer Chemistry;Polymers;Positioning Attribute;pre-clinical;Pre-Clinical Model;Preclinical Testing;Primary Neoplasm;Principal Investigator;Proliferating;Property;propylene;Prostate;protein expression;Reactive Oxygen Species;Repression;research clinical testing;Running;Serum Markers;side effect;Site;skeletal;skeletal-related events;small molecule;small molecule inhibitor;Stains;standard of care;Subgroup;Sulfides;System;systemic toxicity;Technology;Testing;Toxic effect;transcription factor;Translations;treatment effect;tumor;Tumor Burden;Tumor Cell Invasion;Tumor Expansion;tumor growth;Universities;Up-Regulation;validation studies;Woman;Work;Zoledronic Acid

PROJECT_TITLE: Next Gen Targeted nanoparticles for Inhibiting Gli2 in Bone Metastatic Tumors


ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: RELEVANCE Bringing people from different cultures with diverse life experiences to the research endeavor is an important advantage for our country in developing and maintaining innovation in cutting-edge research science. The primary goal of the project is to prepare undergraduate students from underrepresented groups and those who are the first in their family to attend college for entry into doctoral programs leading to research careers in the biomedical sciences. MARC trainees perform important research to advance our understanding of the mechanisms of life.

PI_NAMEs: RUBIN, SETH MICHAEL (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Admission activity;CCL7 gene;cohort;Communities;Development;Doctor of Philosophy;Ensure;Environment;Experimental Designs;Faculty;Fellowship;Generations;Goals;graduate school;Institution;laboratory experience;Learning Skill;Measurable;member;Mentors;programs;recruit;Research;research and development;Research Personnel;scale up;Scientist;skills;social;social learning;Students;success;Training;Training Programs;undergraduate student;Underrepresented Students;university student;Writing

PROJECT_TITLE: The MARC Program at UCSC

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]