NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: We propose to define the role of rare protein-truncating mutations in human lifespan and healthspan through state-of-the-art genomic technologies and mouse models. These analyses may pave the way for future aging strategies, targeting highly damaging mutations already in mid-life, thereby decreasing the incidence of age- related diseases in the late life. They may also improve assessment of age-related patterns, disease risks and interventions that extend lifespan and healthspan.

PI_NAMEs: GLADYSHEV, VADIM N. (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Affect;Age;age related;age-related disease;Aging;Alleles;biobank;Centenarian;Cessation of life;cohort;comparative;Complex;Data Set;Development;Disease;disorder risk;early onset;Exhibits;exome;exome sequencing;extend lifespan;Frequencies;Future;Gender;Genes;Genetic;genetic variant;genome wide association study;Genomics;Genotype;Genotype-Tissue Expression Project;Germ-Line Mutation;healthspan;Human;Human Genome;human mortality;improved;Incidence;Individual;Initiator Codon;Intervention;intervention effect;Intervention Studies;late life;Length;Life;life span;Longevity;loss of function;men;Methods;middle age;mortality;mouse model;Mus;Mutation;Organism;Pathway interactions;Pattern;Phenotype;programs;Protein Truncation;rare variant;Risk;RNA Splicing;Role;Sampling;Schedule;Stochastic Processes;Technology;Terminator Codon;Testing;Time;trait;Twin Studies;Variant;Woman

PROJECT_TITLE: Role of rare damaging mutations in aging

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Imprinted genes are critical for normal mammalian development, behavior and energy homeostasis. Genetic and epigenetic mutations have been identified in imprinted genes for a number of human syndromes and cancer. The experiments in this proposal will model such newly identified mutations in individuals with Beckwith-Wiedemann Syndrome and Silver- Russell Syndrome, providing a better understanding of the etiology of the disorders.

PI_NAMEs: BARTOLOMEI, MARISA S. (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Affect;Alleles;Angelman Syndrome;Architecture;Beckwith-Wiedemann Syndrome;Behavior;Binding;Binding Sites;cardiogenesis;Cell Nucleus;Chromatin;chromatin modification;Chromosomes;Defect;Development;Disease;DNA Methylation;dosage;Elements;Engineering;Enhancers;Epigenetic Process;epigenetic regulation;Etiology;Exhibits;experimental study;Failure;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;Genome;Genomic Imprinting;Germ Lines;Goals;GRB10 gene;Growth;H19 gene;Heart;Heterozygote;Homeostasis;Human;human induced pluripotent stem cells;IGF2 gene;imprint;Individual;induced pluripotent stem cell;insight;Introns;Length;Maintenance;male;Malignant Neoplasms;Mammals;Mesoderm;Methylation;Modeling;Modification;mosaic;Mus;Muscle;mutant;Mutation;Nephroblastoma;Neurons;Nuclear;offspring;Parents;Prader-Willi Syndrome;promoter;Protein Isoforms;Regulation;Regulatory Element;Role;sex;Silver-Russell syndrome;Somatic Cell;Syndrome;System;Therapeutic;Tissues;transmission process;tumor progression;Untranslated RNA;Work

PROJECT_TITLE: Sequences controlling H19 Gene Imprinting

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Project Narrative The last decade has seen exciting and rapid progress in the collection of high-throughput multimodal data distinguishing between hundreds of cell types in the brain. However, little is known about how this wealth of information translates into biophysical mechanisms in neural circuits and how these circuits, in turn, produce computation – particularly so in human neocortex. Here we build models that bridge cellular resolution measurements to computational motifs and neural circuits, validate them against experimental measurements in humans and study how specific biophysical mechanisms orchestrate cortical function and associated signals.

PI_NAMEs: ANASTASSIOU, CONSTANTINOS  (contact);KREIMAN, GABRIEL

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Affect;Architecture;Biological;Biological Markers;biophysical model;Biophysical Process;Biophysics;Brain;Catalogs;Cations;cell cortex;Cell model;Cell Physiology;cell type;Cells;Censuses;Characteristics;Collection;Communities;Computer Models;computerized tools;Data;Data Set;density;Detection;Electrophysiology (science);Exhibits;experimental study;extracellular;feasibility testing;Frequencies;Gene Expression Profile;Generations;Genetic Transcription;Goals;hippocampal pyramidal neuron;Human;human model;in vivo;Individual;insight;Ion Channel;large scale data;Link;Measurable;Measurement;Measures;Modality;model building;Modeling;models and simulation;Morphology;multimodal data;multimodality;Neocortex;neocortical;neural;neural circuit;Neurons;neurophysiology;novel;patch clamp;Patch Tests;Pattern;Performance;Physiology;potential biomarker;predictive modeling;Procedures;Property;Resolution;Resources;response;Role;Signal Transduction;simulation;Source;spatiotemporal;statistical learning;Stress Tests;Synapses;Testing;tool;transcriptomics;Translating;translational applications;Validation

PROJECT_TITLE: Towards a biophysical model of human cortical neurophysiological signatures that incorporates cellular and cell type biophysics, transcriptomics, and morphology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(91)S]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: LEBANON

ORG_NAME: CELDARA MEDICAL, LLC

ORG_STATE: NH

PHR: Prophylactic antibody treatment for seasonal and pandemic influenza is crucial to prevent widespread illness and reduce healthcare burdens, especially in high-risk populations. This approach provides immediate immunity, which is essential in situations where vaccines may be less effective or unavailable, such as with new influenza strains. By protecting vulnerable individuals, prophylactic antibodies could play a significant role in minimizing the health and economic impact of influenza outbreaks and supporting public health resilience.

PI_NAMEs: COOPER, COLLEEN DOYLE (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: Amantadine;Animal Model;Antibodies;authority;Avian Influenza;B-Lymphocytes;cell bank;Cell Line;Centers for Disease Control and Prevention (U.S.);Cessation of life;China;Clinic;Clinical;Clinical Pathways;cost;COVID-19 pandemic;Data;Death Rate;Development;Disease Outbreaks;Domestic Fowls;Dose;Drug Kinetics;economic impact;Economics;Event;experimental study;Fatality rate;Ferrets;flu;foot;Frequencies;global health;Goals;Health;Health Priorities;high risk;high throughput screening;Hospitalization;Hour;Human;human monoclonal antibodies;Infection;Influenza;Influenza A virus;Influenza A Virus, H5N1 Subtype;Influenza A Virus, H7N9 Subtype;influenza infection;influenza outbreak;inhibitor;innovation;International;Intervention;Investigational Drugs;Investments;Laboratories;Letters;Life;manufacture;Medical;Modeling;Modernization;Morbidity - disease rate;mortality;Mus;Mutation;Neuraminidase;novel;novel therapeutics;Oryctolagus cuniculus;Oseltamivir;pandemic disease;pandemic influenza;pandemic potential;pandemic preparedness;Pathogenicity;Persons;Pharmaceutical Preparations;Phase;Population;pre-clinical;preclinical development;preclinical study;programs;prophylactic;public health relevance;Readiness;Recording of previous events;research and development;respiratory virus;Rimantadine;Security;Services;social;Suspension Culture;Symptoms;Technology;Temperature;Therapeutic;Therapeutic antibodies;therapeutic candidate;therapeutically effective;Time;Toxic effect;Toxicology;transmission process;Travel;virtual;Virus;wild bird;Work;World Health Organization

PROJECT_TITLE: Development of CM-IAV1 for Treatment of High-risk Pandemic Influenzas

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-C(12)]


ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: NARRATIVE We propose the first validated and detailed study of the superficial white matter (SWM) in the non-human primate brain using neuroanatomical tracers and diffusion MRI based tractography in the same experimental animals. The SWM is a layer of axons underneath the cerebral cortex that connects different brain areas and is affected in neurological diseases such as autism spectrum disorder and Alzheimer’s disease, but there is scant direct knowledge of SWM organization and connectivity. Results will elucidate the SWM fiber systems in the non- human primate brain with translational relevance to the human brain in health and disease.

PI_NAMEs: MAKRIS, NIKOLAOS ;RATHI, YOGESH ;ROSENE, DOUGLAS L;RUSHMORE, RICHARD JARRETT (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: 3-Dimensional;Affect;Alzheimer's Disease;Anatomy;Animal Experiments;Animals;Antibodies;Archives;Area;autism spectrum disorder;Autopsy;Axon;Brain;Cells;Cerebral cortex;Cerebral sulcus;Cerebrum;chronic traumatic encephalopathy;Collection;Communities;Complement;connectome;Data;data mining;data quality;Data Set;density;design;Diffusion Magnetic Resonance Imaging;Disease;ex vivo imaging;experimental study;Feedback;Fiber;Foundations;General Hospitals;Goals;Grant;Head;Health;Histologic;Histological Techniques;Histology;Human;human disease;improved;in vivo;Knowledge;Label;Literature;Location;Macaca;Macaca mulatta;Magnetic Resonance Imaging;Maps;Massachusetts;Methods;millimeter;Modeling;Modernization;Monkeys;Motor;Motor Cortex;MRI Scans;Multiple Sclerosis;Nervous System Disorder;neural;Neuroanatomy;neuroimaging;Neurologic;nonhuman primate;novel;organizational structure;Pathway interactions;Precentral gyrus;Primates;Prosencephalon;Reporting;Research;Resolution;Scanning;Shapes;Slide;Somatosensory Cortex;Source;Structure;System;systematic review;Time;Tissues;Tracer;tractography;Translating;translation to humans;ultra high resolution;Validation;Visualization;white matter;Work

PROJECT_TITLE: Unraveling the Superficial White Matter of the Primate Brain: Tracer-Based Histology and dMRI Tractography Validation

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative The discovery of circRNAs opens an entirely new window into mechanisms of neurodegeneration in Alzheimer's disease and related dementias (AD/ADRD). This proposal seeks to identify and characterize disease-linked circRNAs and RNA-binding proteins (RBPs), and functional changes in circRNAs or circRNA-RBP interactions that modify ADRD neuropathology or neurodegeneration. Successful discovery of key circRNAs or circRNA-RBP interactions in aging human brains could uncover novel biomarkers, disease mechanisms, or therapeutic targets to diagnose, mediate, or prevent the progression of AD/ADRD.

PI_NAMEs: WOLOZIN, BENJAMIN L;ZHANG, XIAOLING  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3-Dimensional;Affect;age related;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Astrocytes;Atlases;axonal degeneration;Binding;Binding Proteins;Binding Sites;Biogenesis;Biology;Brain;Brain region;C9ORF72;circular RNA;Code;crosslinking and immunoprecipitation sequencing;Data;Deposition;Diagnosis;Disease;Elements;Evaluation;Exhibits;Exons;Experimental Designs;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Future;Gene Expression Profile;Gene Proteins;Genes;Genetic;Genetic Diseases;Genetic Polymorphism;Genetic Risk;genetic variant;Genome;genome wide association study;genome-wide;genomic data;genomic locus;Genomics;high throughput screening;Human;Informatics;Investigation;knock-down;Late Onset Alzheimer Disease;Link;Mediating;Messenger RNA;Methods;Microglia;MicroRNAs;Molecular;multi-ethnic;Mutation;Nerve Degeneration;Neurons;neuropathology;novel;novel marker;Nucleotides;Organoids;Pathology;Pattern;Porifera;prevent;Process;Production;protein aggregation;Protein Isoforms;protein metabolism;protein TDP-43;Proteins;Proteomics;Publishing;Quantitative Trait Loci;Recording of previous events;Regulation;Research Design;Ribosomal RNA;RNA;RNA Binding;RNA metabolism;RNA Splicing;RNA-Binding Proteins;Site;Spliced Genes;stathmin;Susceptibility Gene;synaptic function;System;tau Proteins;therapeutic target;Tissues;transcriptome sequencing;Untranslated RNA;Variant;Work

PROJECT_TITLE: Circular RNAs and their interactions with RNA-binding proteins to modulate AD-related neuropathology


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Transplantation

ORG_CITY: WILMINGTON

ORG_NAME: PPD DEVELOPMENT LP

ORG_STATE: NC

PHR: Project Narrative The T-SCCC's objective to provide a broad range of support critical to the design, development, execution, and analysis of DAIT-sponsored clinical research programs in transplantation will promote public health by increasing the accuracy, quality, availability, and timeliness of resultant study data. Services will include statistical design and analysis; clinical protocol development, implementation, and study management; biospecimen tracking (including a tracking database); biospecimen collection kits and/or bulk supplies for mechanistic studies (kitting); manuscript publication support, study management team (SMT) organization and maintenance, and collaboration with other DAIT stakeholders to plan, oversee, execute, and analyze this DAIT-sponsored transplantation research. The results from this clinical research will be essential to minimizing or removing barriers to short- and long-term success of transplantation procedures by reducing the morbidities associated with pharmacological immunosuppression, inducing transplantation immune tolerance, and improving understanding of the immunologic response to allotransplantation.

PI_NAMEs: SEVER, MICHELLE LYNN (contact)

PROGRAM_OFFICER_NAME: HAYES, DEBORAH

PROJECT_TERMS: access restrictions;Address;Adverse event;allotransplant;Area;authority;Biological Assay;Biological Markers;Biometry;Client;Clinical;Clinical Data;Clinical Investigator;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Collection;Communication;Complex;Data;Data Collection;data integrity;data management;data portal;data quality;data quality/integrity;Data Reporting;Data Security;Data Set;data sharing;data standards;database design;Databases;Decentralization;Dedications;design;Development;Development Plans;Diagnosis;digital;empowerment;Enrollment;Ensure;Environment;Epidemiology;Ethics;experience;flexibility;Funding;Genetic study;Good Clinical Practice;Government Programs;Guidelines;Health;Home;Human Resources;Hybrids;Immune response;Immune System Diseases;Immune Tolerance;Immunosuppression;improved;Infrastructure;innovation;Internet;Journals;Knowledge;Label;Leadership;Longitudinal, observational study;Maintenance;Manuscripts;Methodology;Methods;Monitor;Morbidity - disease rate;National Institute of Allergy and Infectious Disease;Online Systems;Participant;participant safety;Patients;Peer Review;Performance;pharmacologic;Positioning Attribute;Prevention;procedure safety;Procedures;Process;programs;protocol development;Protocols documentation;Public Health;Publications;quality assurance;Quality Control;recruit;Regulation;Reporting;Reproducibility;Research;Research Design;Research Personnel;Resources;Safety;sample collection;Sample Size;Science;Scientist;Secure;Security;Serious Adverse Event;service programs;Services;Shipping;Site;Standardization;Statistical Data Interpretation;Structure;success;System;Techniques;Technology;televisit;Time;time use;Training;Transplantation;Visit;Visualization;Work

PROJECT_TITLE: PPDs Application for the Transplantation Statistical and Clinical Coordinating Center (T-SCCC) (U01 Clinical Trial Not Allowed)


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative The HIV epidemic continues to impact racial and ethnic minority populations disproportionately. We propose to test the implementation of ARC (Accessibility, Responsiveness, Continuity) in a randomized controlled trial to improve organizational behavior and reduce racial disparities in HIV outcomes for people living with HIV.

PI_NAMEs: JEMMOTT, JOHN BARTON;MOMPLAISIR, FLORENCE M (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Address;Affect;African American;African American population;Age;anti-racism;antiretroviral therapy;arm;Attitude;Behavior;Biometry;Black Populations;Black race;Caring;Clinic;Clinical;Collaborations;community transmission;cost;Data;Discrimination;diversity and inclusion;Education;effectiveness outcome;effectiveness testing;Epidemic;ethnic minority population;Ethnic Population;Evidence based intervention;Evidence based practice;experience;Geographic Information Systems;Goals;Health equity research;health inequalities;Healthcare Systems;Hispanic Populations;HIV;HIV diagnosis;implementation intervention;implementation outcomes;implementation science;implementation strategy;improved;Individual;Inequity;information system analysis;innovation;Insurance;Literature;Measures;Mediating;Mental Health;Modeling;multilevel analysis;Neighborhoods;organizational climate;Organizational Culture;Outcome;Outcome Study;Outcomes and Health Services Research;Outpatients;Patient Care;Patient-Focused Outcomes;Patients;perceived discrimination;Perception;Personal Satisfaction;Persons;Phase;Philadelphia;Population;post implementation;Poverty;Preparation;primary outcome;Psyche structure;Psychometrics;Public Health;Publishing;Quality of Care;racial disparity;racial minority population;racial population;Randomized;Randomized, Controlled Trials;Reporting;Research;retention rate;secondary outcome;Self Efficacy;social cohesion;Social Environment;social organization;standard of care;Structural Racism;Testing;therapy adherence;therapy development;tool;Treatment outcome;treatment pattern;Viral;Work

PROJECT_TITLE: Improving the Organizational Social Context to Address Structural Racism and Discrimination: A Randomized Controlled Trial to Reduce Racial Disparities in Viral Suppression and Retention in HIV Care


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Epilepsy;Infectious Diseases;Malaria;Neurodegenerative;Neurosciences;Pediatric;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Cerebral malaria continues to impact over half a million children annually, with 10-16% developing epilepsy within 2 years, and as such is a large contributor to the global epilepsy burden worldwide. This proposal will use cerebral malaria as model of acquired epilepsy, studying the ability of acute and recovery phase quantitative EEG measures in combination with clinical metrics in prediction of post- cerebral malaria epilepsy development. The findings of this study will inform the ability to appropriately allocate resources for children with cerebral malaria, lay the foundation for potential anti-epileptogenesis trials, and provide further understanding of acquired epilepsies as a whole for future study.

PI_NAMEs: PATEL, ARCHANA A. (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: acquired epilepsy;Acute;Affect;Africa;American;Antiepileptogenic;Area;Asphyxia Neonatorum;Award;Benchmarking;Biological;Biological Markers;biomarker identification;Brain;career;career development;Cerebral Malaria;Characteristics;Child;Childhood;childhood epilepsy;Classification;Clinical;Clinical Data;Clinical Research;clinical risk;Clinical Trials Design;cohort;Coma;Complex;Computer Analysis;cost;design;Development;diagnostic criteria;Disease;Electroencephalography;Enrollment;Epilepsy;epileptiform;Epileptogenesis;Etiology;experience;experimental study;Fever;follow-up;Foundations;Frequencies;Future;Goals;Hospitalization;Hypoglycemia;improved;Individual;Infection;interest;International;Intervention;K-Series Research Career Programs;Knowledge;machine learning algorithm;Malaria;malaria infection;Measures;Mentors;Modeling;Monitor;Motor;motor impairment;National Institute of Neurological Disorders and Stroke;Nature;neurodevelopment;Neurologic Dysfunctions;Neurology;neurophysiology;Outcome;Parasites;Participant;patient oriented;Patients;Phase;Population;potential biomarker;preclinical study;predictive modeling;Predictive Value;prevent;Process;prognostication;prospective;Publishing;Questionnaires;Recording of previous events;Recovery;Regional Disease;Research;Research Methodology;Research Proposals;Resource Allocation;Resource-limited setting;Resources;response;Risk;Risk Factors;risk prediction;Risk Reduction;Seizures;Severities;Severity of illness;skills;Societies;Statistical Methods;supervised learning;Survivors;System;Targeted Research;Testing;Time;Training;training opportunity;Translating;trend;Visual;Zambia

PROJECT_TITLE: Predicting Epilepsy in Cerebral Malaria: Working Toward Identifying Biomarkers of Epileptogenesis in Children

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Nutrition

ORG_CITY: ANAHEIM

ORG_NAME: LEBRUN LABS, LLC

PHR: Narrative The proposed studies will test the hypothesis that an eye wash solution containing antioxidants can protect and/or reverse free radical damage to the eye caused by strongly oxidative chemicals. The long-term goal of the proposed research is to reduce suffering and potentially save one’s vision after exposure to toxic substances during a chemical attack. 1

PI_NAMEs: LEBRUN, STEWART  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Accidents;Address;Antioxidants;Apoptosis;Ascorbic Acid;Biochemical;Biological Assay;Blindness;Buffers;Cell Death;Cell Differentiation process;cell growth;Cell Survival;Cells;chemical threat;Chemical Warfare;Chemical Weapons;Chemicals;Code;Cornea;Corrosion;Corrosives;Defense Mechanisms;Dose;experience;experimental study;Exposure to;Eye;F-Actin;Film;Formulation;Free Radicals;Goals;Human;Hydrogen Peroxide;Hypochlorite;improved;interest;International;Lipids;Measurement;Measures;Modeling;Necrosis;Nuclear;Oryctolagus cuniculus;Outcome;Oxidants;oxidation;oxidative damage;Oxides;Peracetic Acid;Physiological;Poison;Procedures;Proteins;Protocols documentation;Research;Research Design;response;Saline;Security;Stains;Sulfur;symposium;Terrorism;Testing;Time;Tissues;Titrations;Transportation;Treatment Protocols;United States Environmental Protection Agency;Vision

PROJECT_TITLE: Antioxidant Eye Wash Formulations to Counter Ocular Chemical Threats

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-F(54)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Narrative The next generation of medicines and therapies that promote health and reduce illness will come from the pool of student scientists who we are currently training. Students from underrepresented groups are an untapped and growing talent pool that can contribute in unique ways to address the urgent health questions facing us. The proposed MARC program leverages the research strengths and the large population of talented students from of the University of California, Berkeley to train the next generation of diverse scientists who will provide the discoveries necessary to make our lives healthier.

PI_NAMEs: LUMPKIN, ELLEN A (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;Assessment tool;California;career;CCL7 gene;cohort;design;Development;disabled;Doctor of Philosophy;Educational workshop;Evaluation;experimental study;First Generation College Students;flexibility;Future;Goals;Grant;improved;Institution;Intention;Journals;matriculation;Mentors;Modeling;next generation;oral communication;programs;Research;Running;Science;Scientist;Self Efficacy;Series;Shapes;skills;socioeconomics;Students;success;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;Universities;Writing

PROJECT_TITLE: The UC Berkeley MARC: Shaping the Next Generation of Scientific Leaders

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Women's Health Research

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE This proposal addresses a critical problem in human affective neuroscience - the inability to measure and fractionate the neural representations of defensive behaviors/decisions and subjective emotions across different levels of threat imminence. Upon conclusion, the research undertaken in this proposal will provide a deeper understanding of the human defensive circuits, their relationship to defensive behaviors/decisions, the neural representation of subjective emotional states, provide closer links with contemporary animal models and promise new avenues to explore how defensive circuits breakdown in anxiety disorders.

PI_NAMEs: MOBBS, DEAN  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Acute;Address;affective neuroscience;Amygdaloid structure;Animal Model;Anxiety;Anxiety Disorders;avoidance behavior;Behavior;behavior measurement;Behavioral;Behavioral Assay;Brain;Brain region;Diagnostic;Emotional;emotional experience;Emotions;Equilibrium;Event;Failure;Female;Fractionation;Fright;Future;Glossary;Goals;Human;Hypothalamic structure;insight;interest;Knowledge;Learning;Link;male;Measurement;Measures;neural;novel;Outcome;psychiatric symptom;Research;Research Domain Criteria;response;Rodent;Role;sex;Sex Differences;sex disparity;System;Validation;Work

PROJECT_TITLE: Fractionating human defensive circuits across changing levels of threat imminence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-N(02)M]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Our KL2 program will develop the careers of translational scientists who will possess both the fundamental competencies and the 7 essential characteristics that will enable them to become transformational agents of change across the translational spectrum.

PI_NAMEs: KIEFE, CATARINA I. (contact)

PROGRAM_OFFICER_NAME: GANNOT, GALLYA

PROJECT_TERMS: Address;Adopted;Advisory Committees;Attention;career;career development;Caring;catalyst;Characteristics;Clinical;Collaborations;commercialization;Communities;Competence;Creativeness;Data Science;design;Development;Development Plans;Doctor of Philosophy;Education;Educational Curriculum;Ensure;Entrepreneurship;experience;Extramural Activities;Faculty;Feedback;flexibility;Fostering;Funding;gender diversity;Goals;Health;Health system;Healthcare;implementation science;Individual;innovation;Institution;Instruction;interest;Leadership;Learning;meetings;Mentors;Methods;Modeling;National Center for Advancing Translational Sciences;Pathway interactions;Persons;Process;programs;Qualifying;racial diversity;Research;Research Personnel;role model;Rural Health;Rural Population;sabbatical;Science;skills;sociodemographics;Structure;System;Time;TNFSF15 gene;Training;Training Programs;translational pipeline;Translational Research;translational scientist;United States National Institutes of Health;Urban Population;Vulnerable Populations;Work

PROJECT_TITLE: Institutional Career Development Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Childhood Injury;Clinical Research;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Unintentional Childhood Injury

ORG_CITY: SEATTLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Bronchopulmonary dysplasia (BPD) causes severe lung disease in over 10,000 extremely premature infants per year in the United States. This project seeks to understand how anti-inflammatory factors such as the cytokine IL-33 modulate lung injury in BPD patients. Results from this study may inform development of future therapies to treat bronchopulmonary dysplasia in these fragile infants.

PI_NAMEs: ELDREDGE, LAURIE CHRISTINE (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Acute;Advisory Committees;Affect;Alveolar;Amphiregulin;Anti-Inflammatory Agents;aspirate;Asthma;Automobile Driving;Award;Basic Science;Biological Markers;Birth;Blood;Bronchopulmonary Dysplasia;career development;Caring;Cell Communication;cell injury;Cells;Child;Childhood;Chronic;Chronic lung disease;Clinic;Clinical;Coculture Techniques;comparative;Complement;conditional mutant;critical period;Cystic Fibrosis;cytokine;Data;Development;developmental immunology;Disease;Doctor of Medicine;Doctor of Philosophy;Doctor of Veterinary Medicine;Dominant-Negative Mutation;Down-Regulation;Epidermal Growth Factor Receptor;Epithelial Cells;epithelial injury;Epithelium;experience;experimental study;Exposure to;extreme prematurity;Future;Goals;Growth Factor;Histologic;Human;Hyperoxia;hyperoxia induced lung injury;Immune;Immune response;Immunity;Immunobiology;Immunologics;immunoregulation;improved;in utero;Infant;Inflammation;Inflammation Mediators;Inflammatory;Innate Immune Response;Intubation;ITGAM gene;K-Series Research Career Programs;Lung;Lung Diseases;lung injury;Macrophage;Master of Public Health;Mediating;Medicine;Mentors;Messenger RNA;Modeling;Molecular;monocyte;mortality;mouse model;multidisciplinary;Mus;Mutant Strains Mice;Neonatal;Neonatal Brain Injury;neonatal immune system;neonatal lung injury;neonatal mice;Neonatal Mortality;novel;Oxygen;paracrine;Pathogenesis;Pathogenicity;Pathologist;Pathway interactions;Patients;Pediatric Hospitals;peripheral blood;Physiological;potential biomarker;Predisposition;Premature Infant;professor;Proliferating;prospective;pulmonary function;receptor;repaired;Research;Research Institute;Research Personnel;response;Risk;Role;Sampling;Scientist;Severities;Signal Transduction;Sorting;Source;supplemental oxygen;Testing;Trachea;transcriptome sequencing;Translational Research;translational scientist;United States;United States National Institutes of Health;Universities;Washington;Wild Type Mouse;Work

PROJECT_TITLE: The role of IL-33 in hyperoxia-induced neonatal lung injury and bronchopulmonary dysplasia

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: LAGOS

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: COLLEGE OF MEDICINE, UNIVERSITY OF LAGOS

PHR: Project Narrative The adoption of a validated molecular-based p16/Ki-67 dual-staining technology (DUST) protocol could improve screening performance in women living with HIV (WLHIV) and thereby increase screening intervals and minimize the overall cost of screening and procedure-related anxiety due to the fear of cancer. The research proposed in this application, “COMParative ASSessment of p16/Ki-67 Dual Staining Technology in WLHIV (COMPASS-DUST)” will aim to evaluate the performance of DUST as a new cervical cancer screening method in WLHIV. The K43 career development program will give me access to resources to carry out the proposed research and training activities with the guidance of established mentors and co-mentors in Nigeria and the US, and also develop my capacity to translate the key findings from current and future studies into public health practice application.

PI_NAMEs: OKUNADE, KEHINDE SHARAFADEEN (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Accreditation;Acetic Acids;Address;Adoption;Adult;Africa;Africa South of the Sahara;aged;Anxiety;career;career development;Cervical;Cervical Cancer Screening;Cervical Intraepithelial Neoplasia;Client satisfaction;Clinical;clinical epidemiology;Clinical Trials;Collaborations;college;Colposcopy;comparative;Comparative Study;cost;cost effectiveness;Cytology;Data;design;Detection;Diagnosis;diagnostic accuracy;Discipline of obstetrics;Disease;DNA;Effectiveness;Enrollment;epidemiology study;Evaluation;experience;follow-up;Fright;Future;Goals;Grant;Gynecology;HIV;HIV risk;HIV Seronegativity;HIV-1;HPV-High Risk;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;improved;innovation;Interdisciplinary Study;interest;Journals;lecturer;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Manuscripts;Medicine;Mentors;Methods;Molecular;Nigeria;Pap smear;Participant;Performance;performance tests;Physicians;Positioning Attribute;prevent;Procedures;Program Development;programs;progression risk;Prospective, cohort study;Protocols documentation;Public Health;Public Health Applications Research;Public Health Practice;Publications;rapid test;Recommendation;reproductive tract;Research;Research Activity;research and development;Research Design;Research Personnel;Research Project Grants;Resource-limited setting;Resources;Risk;Sampling;Scientist;screening;Secure;Severities;sexually active;skill acquisition;skills;Specificity;Stains;Technology;Testing;Time;Training;Training Activity;Training Programs;Translating;treatment center;Triage;United States;Universities;uptake;Vagina;Visual;Woman;World Health Organization;Writing

PROJECT_TITLE: COMParative ASSessment of p16/Ki-67 DUal Staining Technology in women living with HIV (COMPASS-DUST study)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-L(57)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Genetics;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Skin Cancer

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Built on the uniquely strong foundation our group has established, this study will be the first to systematically and comprehensively develop paradigm-shifting SDL (statistically principled deep learning) techniques for G-E (gene-environment) and I-E (histopathological imaging-environment) interaction analysis for cancer prognosis. The analysis of the Yale SPORE and TCGA data on melanoma and lung cancer will deliver prognosis model with superior prediction performance and new markers with sound biological interpretations, further advancing translational research and better informing clinical practice.

PI_NAMEs: MA, SHUANGGE  (contact)

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: analysis pipeline;Architecture;Award;Benchmarking;Biological;Black Box;Cancer Biology;Cancer Prognosis;Characteristics;Clinical;clinical decision-making;clinical practice;Computer software;cost;Data;deep learning;Development;Environment;Environmental Risk Factor;Foundations;gene environment interaction;Gene Expression;Genes;Genetic;Goals;high dimensionality;Image;improved;Inherited;innovation;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Melanoma;Methodology;Methods;Methylation;MicroRNAs;Modeling;Molecular;multidimensional data;Mutation;neural network architecture;Noise;Non-Hodgkin's Lymphoma;novel;novel marker;Oncogenes;Outcome;Performance;Prevention;Prognosis;prognostic model;Proteins;Role;screening;Series;Signal Transduction;sound;statistics;Tail;Techniques;The Cancer Genome Atlas;therapy development;training data;Translational Research

PROJECT_TITLE: Novel Methods for Identifying Genetic Interactions for Cancer Prognosis

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ORG_CITY: ANN ARBOR

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Aortic dissection (AD) is a potentially lethal disease, with chronic patients subjected to lifelong risks (such as aortic growth, rupture and death) that require specialized care, lifelong follow up and potentially repeat interventions. Current techniques for predicting risk in AD patients are limited and largely based on simple anatomic measurements which do not capture the functional processes believed to play an important role development of aortic growth and complications. Using a combination of state-of-the-art medical imaging techniques, this project will deliver functional measures of aortic pressure and wall stiffness, enabling us to shift the paradigm of patient assessment to provide timely, individualized medical and surgical care.

PI_NAMEs: BURRIS, NICHOLAS SCOTT (contact);NORDSLETTEN, DAVID ALEXANDER

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: 3-Dimensional;4D MRI;Acute;Adverse event;Anatomy;Angiography;Aorta;Aortic Aneurysm;Aortic Rupture;Behavior;Biological Markers;Biomechanics;biomedical referral center;Blood flow;Cardiac;Caring;Cessation of life;Characteristics;Chest;Chronic;Chronic Phase;Clinical;Clinical Assessment Tool;Compensation;cost;Country;Data;Development;Diameter;Disease;Disease Progression;Dissection;Emerging Technologies;Enrollment;Equilibrium;Evaluation;Evolution;experience;follow-up;Follow-Up Studies;Functional disorder;Functional Imaging;Goals;Growth;hemodynamics;high risk;Hospitals;Image;Image Analysis;imaging biomarker;imaging modality;Imaging Techniques;improved;individualized medicine;innovation;Intervention;Life;longitudinal, prospective study;Machine Learning;Magnetic Resonance Imaging;Maps;Measurement;Measures;Medical;Medical Imaging;Medicine;Methods;Michigan;minimally invasive;mortality;Motivation;non-invasive imaging;novel;Operative Surgical Procedures;Outcome;overtreatment;patient population;Patient Recruitments;Patients;Periodicity;personalized predictions;personalized risk prediction;Phase;Physics;Play;Positioning Attribute;predictive tools;pressure;primary outcome;Process;Prognosis;prospective;Pulsatile Flow;repaired;Risk;Risk Estimate;risk prediction;Role;Rupture;Scanning;spatiotemporal;Statistical Models;Techniques;Technology Assessment;Time;Tissues;treatment strategy;Unnecessary Procedures;Work;X-Ray Computed Tomography

PROJECT_TITLE: Non-invasive hemodynamic and biomechanic imaging methods for early risk prediction in aortic dissection

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative  There is a critical need to understand the metabolic stress pathways involved in renal cell carcinoma (RCC) development and to develop treatments that target the fundamental metabolic vulnerabilities in RCC. The objective of this application is to study the roles and mechanisms of the RCC tumor suppressor BAP1 in the regulation of ferroptosis and glucose dependency, and the relevance of this regulation to renal tumor development and treatment. Our proposed studies will have significant impact on both our understanding of the fundamental mechanisms of metabolic stress response and our ability to target nutrient dependency in renal cancer treatment.

PI_NAMEs: GAN, BOYI  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: biological adaptation to stress;Bypass;cancer therapy;Cell Death;Cell Death Induction;Cessation of life;Chromatin;Clear cell renal cell carcinoma;Clinical;clinically relevant;Communities;Complex;Cysteine;Cystine;Data;Dependence;derepression;Deubiquitination;Development;effective therapy;effectiveness evaluation;Exhibits;gene repression;Genetic Transcription;Genetically Engineered Mouse;Glucose;Glucose Transporter;Goals;Growth;Histones;Homeostasis;inhibitor;innovation;insight;interdisciplinary approach;Kidney Neoplasms;Link;Malignant Neoplasms;Mediating;Medical;Metabolic;metabolic abnormality assessment;Metabolic stress;mouse model;mutant;Mutate;Mutation;NADP;novel;novel therapeutic intervention;novel therapeutics;Nutrient;Oncogenes;Outcome;Pathway interactions;Patients;Polycomb;pre-clinical;Proteins;Publications;Regulation;Renal Carcinoma;Renal Cell Carcinoma;Research;Resistance;Role;Signal Pathway;Signal Transduction;Testing;therapeutic target;tumor;Tumor Suppression;Tumor Suppressor Genes;Tumor Suppressor Proteins;ubiquitin isopeptidase;Ubiquitination;United States;uptake;Xenograft Model

PROJECT_TITLE: Studying metabolic stress signaling in renal cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: Project Narrative Social behavior deficits are common features of myriad psychiatric illnesses known to have roots in early development, including autism, schizophrenia and anxiety. Yet, there is little understanding of the ontogeny of social behavior in typically-developing individuals. The proposed studies are aimed towards dissecting the neural circuitry supporting flexible social behavior in typical and perturbed development.

PI_NAMEs: OPENDAK, MAYA  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Acceleration;Address;Adult;Age;age related;Animals;Anxiety;approach behavior;Architecture;autism spectrum disorder;Behavior;Behavioral;behavioral response;Brain;Caregivers;caregiving;Complex;Cues;Data;design;Development;Disease;Dissection;Dopamine;early experience;Early identification;Equation;Equilibrium;Etiology;experience;experimental study;Fiber;flexibility;Food;FOS gene;Functional disorder;Genetic;genetic approach;Glutamates;Goals;Growth;Habenula;Hyperactivity;in vivo;Individual;infancy;Infant;Lateral;Life;Link;Major Depressive Disorder;Maps;Measures;Medial;Mental disorders;metabolic imaging;Modeling;neural;neural circuit;Neurons;Odors;optogenetics;Partner in relationship;peer;Photometry;Population;postnatal;Prefrontal Cortex;premature;Process;Prosencephalon;Psychopathology;Publishing;pup;Rattus;Resources;Rodent;Role;Schizophrenia;Signal Transduction;social;social adversity;Social Behavior;social deficits;Social Environment;Social Interaction;Social Responsibility;System;Techniques;Testing;timeline;tool;uptake;Ventral Tegmental Area;Weaning;With laterality;Work

PROJECT_TITLE: Identifying a role for the lateral habenula in typical and perturbed social behavior development

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Mental Health;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PUBLIC HEALTH RELEVANCE: Synucleinopathies such as LBD and PDD are some of the most common and fastest growing age-related neurodegenerative diseases in the world, and contribute to mixed pathologies seen in some Alzheimer’s disease. Despite effective treatments for the motor symptoms of tremor, slowness, and stiffness, there are few effective therapies or biomarkers for the cognitive impairment, depression, apathy, and anxiety increasingly recognized as core non-motor features of these diseases. Age is the central risk factor but is rarely studied as a mechanistic contributor in animal models of these cognitive and motivational symptoms. Determining the interaction between aging and synuclein pathology in cognitive and motivational network pathology and symptoms, and testing a non-invasive and potentially disease-modifying therapy, would meet critical needs in mechanistic understanding, imaging biomarkers, and therapeutic and potentially disease- modifying neuromodulation.

PI_NAMEs: BURNS, MATTHEW ROBERT (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Affect;Affective;Affective Symptoms;Age;Age of Onset;age related;age related neurodegeneration;aged;Aging;alpha synuclein;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Animal Model;Anxiety;Attention;Attenuated;Behavior;Behavior assessment;behavior influence;Behavioral;Behavioral Mechanisms;Biological Markers;Brain;Cells;Characteristics;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive testing;Corpus striatum structure;Data;Dementia;Disease;Dorsal;early onset;effective therapy;efficacious treatment;Elderly;Executive Dysfunction;Exhibits;experimental study;Family;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Hallucinations;Human;imaging biomarker;Impaired cognition;Impairment;improved;Impulsivity;Injections;Laboratories;Lewy Body Dementia;Link;Memory;Mental Depression;Mentors;Modeling;Motivation;Motor;Motor Cortex;motor disorder;motor symptom;mouse model;multisensory;Mus;Nerve Degeneration;network dysfunction;neural network;neural patterning;Neurobehavioral Manifestations;neuroimaging;neuromechanism;neuropathology;neuropsychiatry;neuroregulation;non-motor symptom;normal aging;Outcome;Parkinson's Dementia;Pathogenicity;Pathologic;Pathology;Patients;Pattern;Phenotype;pre-clinical research;pre-formed fibril;Prefrontal Cortex;programs;protein aggregation;Proteins;public health relevance;Publishing;Quality of life;Rattus;Research;Rest;Rewards;Risk Factors;Role;Short-Term Memory;Structure;Substantia nigra structure;Symptoms;Syndrome;synuclein;synucleinopathy;Testing;Therapeutic;Tremor;Ventral Striatum;Ventral Tegmental Area;young adult

PROJECT_TITLE: Cognitive and Affective Network Dysfunction and Neuromodulation in Aging and Synucleinopathy

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_DEPT: VETERINARY SCIENCES

PHR: PROJECT NARRATIVE This project will reveal fundamental insights on how neuronal circuits transiently control neonatal vocalization during early postnatal development and might aid our understanding of impaired early life behaviors in neurodevelopmental disorders.

PI_NAMEs: DIETRICH, MARCELO  (contact)

PROJECT_TERMS: Age;Angelman Syndrome;Architecture;ART protein;Attention;autism spectrum disorder;Automobile Driving;Axon;Behavior;Behavior Control;behavioral response;beta-Endorphin;Brain;Brain Mapping;Brain region;Calcium;Caregivers;Caring;Cells;Cessation of life;Coupled;Crying;Development;developmental neurobiology;Electrical Stimulation of the Brain;experimental study;fascinate;Genetic;Goals;Health;Human;Hypothalamic structure;Impairment;in vivo;insight;Laboratories;Life;loss of function;Mammals;Mediating;Monitor;Motivation;mouse development;mu opioid receptors;Mus;neglect;Neonatal;neonatal brain;neonatal mice;neonate;neural circuit;neurobiological mechanism;Neurobiology;Neurodevelopmental Disorder;neuronal circuitry;Neurons;Neurosciences;novel;nutrition;offspring;old mice;Opioid;optogenetics;Output;Peptides;Population;postnatal;postnatal development;postnatal period;Presynaptic Terminals;primary caregiver;Pro-Opiomelanocortin;response;Role;Signal Transduction;social;Software Tools;Specific qualifier value;Structure of nucleus infundibularis hypothalami;Testing;tool;Transgenic Mice;vocal control;vocalization;Weaning

PROJECT_TITLE: Dissecting the modulatory function of hypothalamic neurons in the temporarily restricted emission of vocalizations by neonatal mice

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Respiratory infections are a leading cause of morbidity and mortality worldwide. Influenza is a common respiratory illness that can be complicated by secondary fungal infections of the lung. This research project investigates the mechanisms by which influenza weakens the immune system, predisposing to secondary invasive fungal disease in the lung, providing important information for future therapeutic interventions.

PI_NAMEs: ROBINSON, KEVEN MARA (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: acquired immunodeficiency;Adhesions;Affect;Allergic Bronchopulmonary Aspergillosis;Alveolar Macrophages;Aspergillosis;Aspergillus;Aspergillus fumigatus;Attenuated;attenuation;Bacterial Pneumonia;Blood;C Type Lectin Receptors;Cell Adhesion;Cells;chemokine;Clinical;congenital immunodeficiency;Critical Illness;CXCL1 gene;cytokine;Data;Death Rate;Dendritic Cells;Development;Disease;Effector Cell;Endothelium;Exposure to;fungus;Future;Germination;Goals;Health;Hematopoietic Stem Cell Transplantation;Host Defense;Human;Hyphae;IL17 gene;Immune;Immune response;Immune system;Immunity;Immunocompromised Host;Immunology;in vivo;Infection;Inflammation Mediators;Influenza;Influenza A virus;influenza infection;Inhalation;Innate Immune System;insight;Integration Host Factors;Interferons;intravital microscopy;Invaded;ITGAX gene;Knowledge;Life;Lung;Lung infections;Lung Transplantation;Macrophage;Measures;migration;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Mycoses;Natural Immunity;Neutropenia;neutrophil;Neutrophil Infiltration;novel therapeutic intervention;Organ;pathogen;Pathogenesis;pathogenic fungus;patient population;Patients;Phagocytosis;Phenotype;Population;Predisposition;prevent;Production;receptor;recruit;Reproduction spores;Research;Research Project Grants;respiratory;Respiratory Burst;Respiratory System;Respiratory Tract Infections;response;Risk;Risk Factors;Role;Scientific Advances and Accomplishments;Secondary to;Signal Pathway;Signal Transduction;STAT1 gene;Structure of parenchyma of lung;superinfection;T-Lymphocyte;Therapeutic Intervention;Tissue-Specific Gene Expression;trafficking;Work

PROJECT_TITLE: Influenza Attenuates Innate Pulmonary Host Defense against Invasive Pulmonary Aspergillosis

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The proposed research is relevant because retinopathy of prematurity severely affects up to 10% of extremely premature infants and contributes to long-term neurodevelopmental disability, and results from aberrant oxygen exposure and angiogenic growth factor expression in the retina. Upon conclusion of this project, we will understand the role of epithelial membrane protein-2 (EMP2) in physiologic and pathologic retinal development, angiogenic factor production in the neuroretina in oxygen-induced retinopathy, and whether antibody-mediated targeting of EMP2 can provide protection against abnormal oxygen-induced vascular development. These discoveries lay the foundation for novel therapeutic targets, which protect against aberrant neovascularization and later visual defects in ROP-affected neonates.

PI_NAMEs: CHU, ALISON  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: 3-Dimensional;Adult;Affect;angiogenesis;Angiogenic Factor;Antibodies;Attenuated;attenuation;Biochemical;Biology;Blindness;blood vessel development;Blood Vessels;Cells;Childhood;comparison control;Cornea;Data;Defect;Development;differential expression;Disease;Disease Progression;Endothelium;Environment;Epithelium;Exhibits;extreme prematurity;Extremely Low Birth Weight Infant;Eye;Eye diseases;Foundations;Functional disorder;Genetic;Genomics;Goals;Grant;Growth Factor;HIF1A gene;Histologic;Hyperoxia;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;Image;imaging modality;in vivo;Infant;innovation;interdisciplinary approach;intravitreal injection;Kidney;Knock-out;Knockout Mice;Knowledge;Light;Link;Lung;Malignant Neoplasms;Measures;Mediating;Membrane Proteins;Modeling;mouse model;multidisciplinary;Mus;National Eye Institute;neonate;Neonatology;neovascularization;Neurodevelopmental Disability;Neurons;new therapeutic target;novel;optical imaging;Oxygen;Pathogenicity;Pathologic;Pathologic Neovascularization;Pattern;Phase;Photoreceptors;Physiological;Placenta Diseases;Placentation;Population;Premature Birth;Premature Infant;prevent;Process;Production;Research;Retina;retina blood vessel structure;retinal angiogenesis;Retinal Diseases;Retinal Neovascularization;Retinopathy of Prematurity;Rod;Role;Safety;selective expression;Signal Transduction;single-cell RNA sequencing;Structure;Structure of retinal pigment epithelium;Testing;Therapeutic;therapeutic evaluation;Tissues;Toxic effect;transcriptomics;Treatment Efficacy;Vascular Diseases;Vascular Endothelial Growth Factors;Vascularization;vasculogenesis;VEGFA gene;Visual

PROJECT_TITLE: Targeting epithelial membrane protein 2 (EMP2) in retinopathy of prematurity

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Prostate Cancer;Urologic Diseases

ORG_CITY: HANOVER

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: DARTMOUTH COLLEGE

PHR: PROJECT NARRATIVE Gauging electrical properties of surgical margins during tumor resection procedures has the potential to alert surgeons to regions of cancer not fully extracted and subsequently reduce the number of positive surgical margins which are significantly correlated with cancer recurrence. The intraoperative electrical property sensing/imaging probe and the visualization tools proposed here will provide an accurate, rapid, and cost- effective method for gauging these surgical margins for multiple cancer types. We will explore this technology in the context of prostate cancer surgery with the expectation that this will further advance the study of electrical property signatures of normal and diseased tissue in vivo and help to translate this technology to the clinic.

PI_NAMEs: HALTER, RYAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Adjuvant Therapy;Benign;Biochemical;Bladder Control;Breast;cancer cell;cancer recurrence;cancer surgery;cancer type;Cancerous;Cause of Death;Chemicals;Classification;Clinic;Clinical;Clinical Protocols;Clinical Research;clinically relevant;cost;cost effective;data acquisition;Databases;Death Rate;design;Detection;Devices;Disease;efficacy evaluation;electric impedance;electrical impedance tomography;electrical property;Electronics;Elements;Erectile dysfunction;Evaluation;Excision;expectation;Exposure to;feasibility trial;Financial Hardship;flexibility;Frequencies;Health Personnel;Histopathology;Hormonal;Human;Image;imaging capabilities;imaging probe;Imaging technology;improved;in vivo;Incidence;Incontinence;Institution;Left;Location;machine learning classification;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;man;Maps;Measurement;men;Methods;Microscopic;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Nephrectomy;neurovascular;Operative Surgical Procedures;Organ;Outcome;Pathologic;Pathology;Patients;Pelvic floor structure;Periprostatic;Positioning Attribute;Postoperative Period;Procedures;programs;Property;Prostate;prostate surgery;Prostatic Tissue;prototype;Quality of life;Radiation;Radical Prostatectomy;Recurrence;Regional Cancer;Research Design;Resected;Risk;Running;safety and feasibility;Salvage Therapy;Scheme;Sensitivity and Specificity;Series;Specimen;stem;success;Surgeon;Surgical margins;System;Techniques;Technology;technology validation;Time;Tissue Sample;Tissues;tool;Translating;tumor;Update;Urethra;urinary bladder neck;Urinary Retention;Visualization;Visualization software;Work

PROJECT_TITLE: Microendoscopic Electrical Impedance Sensing for Real-time Intraoperative Surgical Margin Assessment

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE A decline in the number of physician-scientists will impact our nation’s capacity to produce innovative research for patients with vascular disease. Attracting the brightest minds into an academic research career is critical. This project creates a 2-year integrated training program for surgery residents and fellows to develop a career pathway for conducting mechanistic and clinically relevant translational research in vascular disease.

PI_NAMEs: BERCELI, SCOTT A;UPCHURCH, GILBERT RIVERS (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TITLE: Interdisciplinary Training for Vascular Surgeon Scientists

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: ES

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Complementary and Integrative Health;Microbiome;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: NARRATIVE The gut microbiota can be perturbed by environmental factors including diet composition, xenobiotic exposure (e.g., environmental toxicants, antibiotics) and life-style (smoking, exercise, stress, social interactions); thus, a better understanding of the functional role of microbiome and its regulation of host metabolic responses is an important prerequisite for designing microbiome-specific therapeutic strategies. This study will provide insight into how exposure (including dose and timing) to environmentally relevant toxicants interacts with the host and gut microbiota to affect health. Important outcomes include improved understanding of the gut microbiota in the response to toxic insult and the identification of toxicity levels that can be used to establish possible microbial toxicity endpoints which will likely help to inform hazard identification and risk assessment.

PI_NAMEs: PATTERSON, ANDREW  (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Acute;Address;Affect;Antibiotics;Biochemistry;Chemical Exposure;Chemicals;Chronic;collaborative environment;commensal microbes;design;Diet;dietary;Disease;Dose;early life exposure;Environment;environmental chemical;environmental chemical exposure;Environmental Health;Environmental Risk Factor;Enzymatic Biochemistry;Exercise;experience;Exposure to;Gastrointestinal tract structure;Goals;gut microbiota;Hazard Identification;Health;host microbiome;host microbiota;Human;Immune response;Immunology;improved;Inflammatory;Inflammatory Bowel Diseases;innovation;insight;late life;Life Style;Malignant Neoplasms;Metabolic;Metabolic Diseases;Metabolism;microbial;Microbiology;microbiome;microbiota;mouse model;novel;Outcome;Pathway interactions;Physiological Processes;Physiology;Poison;Positioning Attribute;prebiotics;Probiotics;Recording of previous events;Regulation;response;Risk Assessment;Role;Seminal;Signal Pathway;Smoking;Social Interaction;Stress;Technology;Therapeutic;Toxic effect;Toxic Environmental Substances;toxicant interaction;Toxicology;Transcriptional Regulation;Work;Xenobiotics

PROJECT_TITLE: Environmental Chemical Impact on the Host-Microbiome Interaction


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative The progressive accumulation of amyloid beta (Aβ) and tau pathology in Alzheimer’s disease (AD) is associated with dysfunctional neuronal signaling and poor cognitive performance. In this proposal, newly developed machine learning strategies will be used to decode features of task-relevant, spatial information from neural ensemble activity in the entorhinal cortex – hippocampal (EC-HIPP) circuit of transgenic mice expressing Aβ and tau pathology, with the overarching goal of understanding how Aβ and tau interfere with spatial information encoded within neuronal networks. Dysfunctional neuronal populations will then be selectively targeted using chemogenetics to correct their aberrant firing patterns, with the aim of improving the quality of spatial information carried by pathology afflicted neuronal networks.

PI_NAMEs: RODRIGUEZ, GUSTAVO A (contact)

PROJECT_TERMS: 4-Hydroxy-Tamoxifen;abeta accumulation;abeta oligomer;Address;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-42;Amyloid beta-Protein;Attenuated;attenuation;awake;Award;Behavior;Behavioral;career;career development;Cells;Chronic;Code;cognitive performance;combat;Complex;Coupled;Data;design;designer receptors exclusively activated by designer drugs;Development;Development Plans;Electrophysiology (science);Ensure;entorhinal cortex;excitatory neuron;Exhibits;experience;experimental study;Functional disorder;gene therapy;Genetic;Goals;Hippocampus;Hyperactivity;Impaired cognition;Impairment;improved;in vivo;Individual;information processing;J20 mouse;Knowledge;Label;Learning;learning strategy;Ligands;Location;Machine Learning;Maps;Measures;Memory;memory encoding;Mentors;Mentorship;Motion;mouse model;Mus;Muscarinic Acetylcholine Receptor;network dysfunction;neural;neuron loss;neuronal circuitry;Neuronal Dysfunction;neuronal patterning;Neurons;neuroregulation;neurotransmission;novel;old mice;Pathologic;Pathology;Pattern;Peptides;Performance;Play;Population;Process;recruit;Research;response;Role;Scientist;spatial memory;Specificity;Speed;Stimulus;Talents;tau aggregation;tau Proteins;Technical Expertise;Testing;Training;Transgenic Mice;Universities

PROJECT_TITLE: Impaired spatial decoding and neural population code rescaling in AD mice


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: This research will disseminate new electrode tools for recording the electrical activity of muscles in a number of different species and body parts. These novel methods for recording muscle activity may be used to improve clinical measurements of nervous system function and to design rehabilitative therapies.

PI_NAMEs: BAKIR, MUHANNAD  ;SOBER, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: Address;Animals;base;Behavior;Behavior Control;Behavioral;bioelectronics;Body part;Brain;brain control;BRAIN initiative;Central Nervous System;Clinical;Cognition;Communities;Complement;Data;design;Devices;Disease;Educational process of instructing;Educational workshop;Electrodes;Electromyography;Electrophysiology (science);Emotions;Engineering;fabrication;Feedback;Forelimb;Generations;Goals;Health;Hindlimb;Implant;implantation;improved;Letters;Measurement;Measures;meetings;Methods;Monitor;motor behavior;Motor output;Mus;Muscle;Muscle Fibers;Nervous System Physiology;neural;neural circuit;neural patterning;Neurosciences;new technology;next generation;nonhuman primate;novel;Operative Surgical Procedures;orofacial;pandemic disease;Pattern;Perception;Performance;Persons;programs;Protocols documentation;prototype;Rattus;Rehabilitation therapy;Research;Research Personnel;Resolution;Resources;Scientist;sensor;Shapes;Signal Transduction;sobriety;Songbirds;Spinal Cord;success;Surveys;System;Techniques;Technology;Testing;tool;Training;Training Activity;United States National Institutes of Health;Upper Extremity;virtual;Vision;Writing

PROJECT_TITLE: Center for Advanced Muscle BioElectronics (CAMBER)


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Clinicians with training and experience in preventing and treating eye disease, who are also skilled at doing research, are able to identify important problems in vision science and eye care and design the research projects needed to resolve the problems. The Penn Vision Clinical Scientist Program provides the resources necessary for such Scholars to be successful.

PI_NAMEs: DUNAIEF, JOSHUA L (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Applied Research;Area;Award;Basic Science;Bioethics;Clinical;clinical epidemiology;clinical training;Collaborations;Custom;design;Development;Doctor of Philosophy;Doctor's Degree;Education;Educational Activities;experience;Fellowship;Genetic;Grant;Health Services Research;Individual;Lead;medical schools;Mentored Clinical Scientist Development Program;Mentors;Molecular Biology;Multi-Institutional Clinical Trial;Neurosciences;Ophthalmology;patient oriented research;Productivity;programs;Research;Research Activity;Research Personnel;Research Project Grants;Scientist;skills;Time;Training;Translational Research;Universities;Vision;Vision research

PROJECT_TITLE: PENN Vision Clinical Scientist Program


NIH_SPENDING_CATS: Transplantation

PHR: PROJECT NARRATIVE Training students and fellows in transplantation biology provides the next generation of scientists who will improve understanding of transplant rejection and acceptance, and develop treatments to reduce patients’ dependence on immunosuppressive drugs. This training program teaches young scientists the necessary skills to develop research careers in transplantation with a strong emphasis on immunology and cell and molecular biology.

PI_NAMEs: THOMSON, ANGUS W (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Biology;Training;Transplantation

PROJECT_TITLE: Interdisciplinary Training in Transplantation Biology

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Genetics;HIV/AIDS;Infectious Diseases;Lung;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: MIAMI

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: PROJECT NARRATIVE: People living with HIV demonstrate increased lung inflammation and higher incidence of COPD even when adjusted for the smoking status, and disruption of the lung molecular clock has been implicated in elevated lung inflammation associated with COPD and tobacco smoke exposure. We will determine the role of lung molecular clock dysfunction in HIV associated COPD, with therapeutic leads to reset the molecular clock and help reduce underlying inflammation and/or arrest the decline in lung function in HIV smokers/COPD. Understanding the pathophysiological mechanisms by which HIV disrupts the lung molecular clock will provide therapeutic targets for HIV-associated COPD.

PI_NAMEs: RAHMAN, IRFAN ;UNWALLA, HOSHANG JEHANGIR (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Abbreviations;Accounting;Acetylation;Aging;Agonist;Air;airway epithelium;airway inflammation;Anatomy;antiretroviral therapy;ARNTL gene;Biological;bronchial epithelium;Bronchoalveolar Lavage;cell type;Chronic;Chronic Obstructive Pulmonary Disease;Cigarette;cigarette smoke;cigarette smoking;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical;comorbidity;Compensation;Consequences of HIV;Continuity of Patient Care;Coupled;CXCL5 gene;cytokine;Data;Deacetylase;Deacetylation;Development;Disease;Disease Progression;DNA;Epithelial Cells;extracellular;Functional disorder;Gene Expression;Genes;Goals;HIV;HIV Infections;Hour;Human;Immediate-Early Proteins;In Vitro;in vivo;in vivo Model;Incidence;Inflammation;Inflammatory;Inflammatory Response;Link;Liquid substance;Lung;lung injury;Mediating;Molecular;molecular clock;Morbidity - disease rate;mortality;mouse model;Mucous body substance;mucus hypersecretion;non-smoker;novel;nuclease;Output;overexpression;Pathway interactions;Patients;Periodicity;Peripheral;Persons;phosphoramidate;Physiology;Play;Population;Pulmonary Emphysema;pulmonary function;pulmonary function decline;Pulmonary Inflammation;Repression;Resistance;Response Elements;Risk Factors;RNA;Role;Severity of illness;SIRT1 gene;Smoker;Smoking Status;Stimulus;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Tobacco smoke;tobacco smoke exposure;Transactivation;transcriptomics;Transgenic Mice;Transgenic Organisms;United States;Up-Regulation;Viral;Virus Replication

PROJECT_TITLE: Resetting the Clock in HIV associated COPD

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Aging;Neurosciences

PHR: Project Narrative: Nearly all animals, including humans, are governed by an internal circadian clock that regulates biological processes, including memory formation, across the 24h day/night cycle. Both non-pathological aging and Alzheimer’s diseases are accompanied by impairments in both memory and circadian rhythmicity, but the connection between these age-related deficits is currently unclear. This proposal will examine an important circadian gene that may underlie age-related impairments in both memory and circadian rhythmicity and may represent a novel therapeutic target for improving cognition in aging individuals.

PI_NAMEs: KWAPIS, JANINE LYNN (contact)

PROJECT_TERMS: Affect;age related;age-related disease;Aging;aging brain;aging hippocampus;Alzheimer's Disease;Animals;Behavior;Biological Process;Body Temperature;Brain;Brain region;Cells;Characteristics;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;CRISPR/Cas technology;Cyclic AMP-Responsive DNA-Binding Protein;Data;Dorsal;Event;experimental study;Feeding behaviors;Genes;Genetic Transcription;Hippocampus;Human;human old age (65+);Impairment;improved;Individual;knock-down;Learning;life span;long term memory;Measures;Mediating;Memory;memory consolidation;Memory impairment;Memory Loss;mimetics;Molecular;Monitor;Mus;neural;Neurons;new therapeutic target;normal aging;novel;old mice;overexpression;Performance;Periodicity;Phosphorylation;Physiological;Positioning Attribute;Process;Proteins;Regulation;Repression;Rodent;Role;Simplexvirus;Sleep;spatial memory;suprachiasmatic nucleus;targeted treatment;Testing;Therapeutic Intervention;transcription factor;Virus;Work

PROJECT_TITLE: Diurnal control of memory allocation by the circadian gene Per1

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: KANSAS CITY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Diet is known to affect glucose metabolism and insulin resistance and a growing body of evidence suggests that impairments to the status of these processes poses increased risk of Alzheimer’s disease and progression. The aim of this research is to investigate the role of high glycemic diet’s relationship with Alzheimer’s risk and prognosis in older adults. This research could lead the way to inform dietary recommendations for achieving optimal brain health, potentially affecting the lives and well-being of many.

PI_NAMEs: TAYLOR, MATTHEW  (contact)

PROJECT_TERMS: Acute Disease;Address;Adherence;Advanced Development;Advisory Committees;Affect;Aging;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;Amyloid deposition;Area;Assessment tool;Behavior;Blood flow;Brain;brain health;Brain imaging;Burn injury;Carbohydrates;career;Cerebrovascular Circulation;Chronic Disease;Clinical;Clinical assessments;Clinical Research;Clinical Sciences;Clinical Trials;Cognition;Cognitive;cognitive neuroscience;cognitive performance;cognitive testing;cohort;Collection;Complex;Data;Dementia;design;Development;Diabetes Mellitus;Diet;dietary;dietary adherence;Dietary Assessment;Dietary intake;Dietary Intervention;Dietetics;Disease;disease prognosis;effective therapy;Elderly;experience;Fat-Restricted Diet;forging;Funding;Future;glucose metabolism;Goals;Health;imaging facilities;Impairment;Individual;Influentials;Infrastructure;innovation;Institution;Insulin Resistance;Intervention;Kansas;Knowledge;Lead;Learning;Link;Magnetic Resonance Imaging;Measures;Mediating;Medical center;Mediterranean Diet;Mentored Research Scientist Development Award;Mentors;Mentorship;metabolic profile;Metabolic syndrome;Metabolism;Methodology;Methods;Modeling;neuroimaging;Neurosciences;novel;nutrition;Nutritional;Nutritional Science;Nutritional Study;older adult;Outcome;Participant;Pattern;Peripheral;Personal Satisfaction;prevent;Prevention strategy;Preventive;Process;professor;Prognosis;Public Health;Recommendation;Research;Research Methodology;Research Personnel;Risk Marker;Role;Scientist;skills;Spectrum Analysis;Standardization;Structure;sugar;Techniques;tenure track;Testing;theories;Therapeutic;therapy development;tool;Training;training opportunity;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: High Glycemic Diet and Alzheimer's Risk


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Pediatric

PHR: NARRATIVE More pediatric physician scientists are needed to define the pathophysiology of Pediatric Endocrine disease and to allow for the development of new treatments. Our program is one of approximately a dozen T32 grants devoted solely to Pediatric Endocrinology, and although relatively young, our graduates have begun to fill voids and assume academic leadership roles in pediatric endocrinology. This has allowed for a better understanding of and ultimate cure for disorders targeted as national public health priorities, including pediatric diabetes and obesity.

PI_NAMEs: OBERFIELD, SHARON E. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: Training Grant in Pediatric Endocrinology, Diabetes and Metabolism

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) is a devastating neurodegenerative disease, the third most common cause of mortality in the United States, and a looming public health crisis. Despite over a decade of genome-wide association studies (GWAS), our understanding of the genetics of this devastating disease remains incomplete, as functional validation of relevant polymorphisms has proved challenging. Through a platform of multi-omic single-cell data generation, innovative machine learning and statistical genomics refinement, and functional characterization, we will pinpoint AD-relevant polymorphisms that will identify novel aspects of disease pathogenesis and nominate candidate avenues for therapeutic intervention.

PI_NAMEs: KUNDAJE, ANSHUL ;MONTGOMERY, STEPHEN ;MONTINE, THOMAS J (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Address;Adult;Affect;Alleles;Alzheimer's Disease;Alzheimer's disease risk;analytical method;Atlases;base;Biological Assay;Biology;Brain;brain cell;Brain region;Catalogs;Cell Nucleus;Cell Physiology;cell type;Cells;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Cognitive;cohort;Collaborations;Communities;comparison control;Data;Data Set;data sharing;deep learning model;Dementia;Dementia with Lewy Bodies;Development;Disasters;Disease;Encyclopedia of DNA Elements;Environment;Etiology;Exhibits;experience;functional genomics;Gene Expression;Gene Expression Regulation;gene function;Generations;Genes;Genetic;Genetic Diseases;Genetic Polymorphism;Genetic Predisposition to Disease;Genome;genome editing;Genome Mappings;genome sequencing;genome wide association study;Genomics;Genotype-Tissue Expression Project;Goals;Heritability;improved;in vitro Model;induced pluripotent stem cell;Inherited;innovation;Investigation;Joints;Link;Linkage Disequilibrium;Machine Learning;member;Methods;Modeling;mortality;Multiomic Data;multiple omics;Mutation;Neurodegenerative Disorders;neuropathology;novel;Pathogenesis;Pathologic;Phenotype;Positioning Attribute;presenilin-1;Public Health;rare variant;Regulatory Element;Reporter;Research;resilience;Resolution;Resources;Risk;Risk Factors;risk variant;RNA Splicing;Role;Science;Scientist;single cell technology;Single Nucleotide Polymorphism;single nucleus RNA-sequencing;Specificity;syntax;The Cancer Genome Atlas;Therapeutic Intervention;Training;transcription factor;TREM2 gene;United States;Universities;Untranslated RNA;Validation;Variant;whole genome;Work

PROJECT_TITLE: Multi-omic functional assessment of novel AD variants using high-throughput and single-cell technologies


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Mental Health;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Antisocial behavior is common in frontotemporal dementia and can have severe consequences when patients break the law. The proposed research will use moral decision-making tests and neuroimaging to better understand the cognitive and neural mechanisms leading to these behaviors. This knowledge will inform future studies aimed at identifying, preventing, and treating antisocial behavior in dementia.

PI_NAMEs: DARBY, RICHARD RYAN (contact)

PROJECT_TERMS: Address;Affective;Aging;Alzheimer's Disease;Amygdaloid structure;anti social;antisocial behavior;Atrophic;Behavior;Behavioral;Behavioral Symptoms;Biometry;Brain;Brain Injuries;Brain Mapping;Brain region;cerebral atrophy;Clinical assessments;Clinical Management;Clinical Trials;Cognitive;Complex;Computing Methodologies;connectome;Crime;Decision Making;Delusions;Dementia;effective intervention;effective therapy;Emotional;Ethics;Executive Dysfunction;Frontotemporal Dementia;Future;Goals;Grant;Human;Impaired cognition;Impairment;improved;Knowledge;Laws;Leadership;Learning;Legal;Lesion;Link;Location;man;Maps;Measures;Memory impairment;Mentors;Mentorship;Methods;Monitor;Morals;Morbidity - disease rate;multimodal neuroimaging;network dysfunction;neural;Neuroanatomy;Neurodegenerative Disorders;neuroimaging;Neurologic Symptoms;Neurologist;neuromechanism;neuropsychiatric symptom;Neuropsychology;neuroregulation;novel;Outcome Measure;Patients;Performance;pharmacologic;Policies;prevent;Problem behavior;Process;Psychometrics;psychopathic personality;Reaction;Research;research clinical testing;Research Personnel;response;Rewards;Severities;skills;social;Social Behavior;social norm;Standardization;Symptoms;Task Performances;Techniques;Testing;Theft;Training;treatment strategy;Use of New Techniques;Violence;Work;Writing

PROJECT_TITLE: Cognitive and Neural Mechanisms of Antisocial Behavior in Frontotemporal Dementia

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


ORG_CITY: TUCSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative – Public Health Relevance: This application proposes exploration of a novel, label-free, optical approach to detect low concentrations of disease biomarkers. Sensitive and robust detection of disease biomarkers is important not only for enabling early detection of the disease, but also to support current efforts to develop early treatments and prevention therapies.

PI_NAMEs: SU, JUDITH  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: addiction;Air;Alzheimer's Disease;Antibodies;Area;Bacteria;Basic Science;Biological;Biological Assay;Biological Markers;Breathing;cantilever;Chemicals;citizen science;Clinical;Country;Detection;Devices;Diabetes Mellitus;Diagnosis;Disease;Disease Progression;drinking;drinking water;Early Diagnosis;Early treatment;empowerment;Feedback;Food;Frequencies;Human;Immobilization;Insulin;interest;Interleukin-2;Label;Libraries;macromolecule;Malignant Neoplasms;Mental Depression;Methods;Microscopic;molecular marker;Monitor;Multiple Sclerosis;nano;nanoscale;nanowire;Noise;Nose;novel;Optics;Pain;Pharmaceutical Preparations;portability;Prevention therapy;Probability;Process;Prognosis;public health relevance;rapid detection;screening;Signal Transduction;single molecule;small molecule;Smell Perception;System;translational medicine;Virus

PROJECT_TITLE: Label-free single molecule detection for basic science and translational medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Microbiome;Nutrition;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: NARRATIVE Host microbial communities (microbiota) profoundly affect our health and are changed by antibiotics. However, microbial disturbances during treatment for drug-resistant tuberculosis (a leading cause of death for which tens of millions of antibiotics doses are prescribed annually) remain uncharacterized and may help explain clinical outcomes and long-term overall health, including post-treatment sequalae. Through leveraging of an already- funded observational cohort of drug-resistant TB patients on treatment, we will evaluate microbiota changes before, during, and after treatment (including how these changes correspond to drug absorption), how specific taxa correspond to microbial metabolic end-products, and the microbiota’s association with treatment response. This program of work will also, through structured and dedicated career development, strengthen South African analytical capacity in the microbiome and inform future clinical trials that modulate the microbiome in the context of TB.

PI_NAMEs: NAIDOO, CHARISSA CAMILLE (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: 16S ribosomal RNA sequencing;absorption;Acetates;Adolescent;Adult;Affect;African;Aftercare;Anaerobic Bacteria;Antibiotic Therapy;Antibiotics;Antitubercular Antibiotics;Butyrates;career;career development;Cause of Death;Clinical;Clinical Trials;cohort;Collaborations;combinatorial;Combined Antibiotics;commensal microbes;Computing Methodologies;Data;Dedications;design;diagnostic tool;Dietary Supplementation;Dose;Drug Kinetics;Drug resistance in tuberculosis;drug-sensitive;Enterobacter;Enterobacteriaceae;Epidemic;Ethambutol;Etiology;experimental study;Feces;Foundations;Funding;Future;global health emergency;gut microbiota;Health;Health Benefit;HIV;Hospitals;host microbiome;Human Microbiome;human microbiota;Immune;immunoregulation;improved;Inflammatory;Injections;Intervention;isoniazid;Klebsiella;Knowledge;Leukocytes;Levaquin;Life;Linezolid;longitudinal analysis;low and middle-income countries;Mass Chromatography;Mass Fragmentography;Mass Spectrum Analysis;Measures;Mediator;medical schools;Mentors;Mentorship;Metabolic;Metadata;microbial;microbial community;microbial host;microbiome;microbiome research;microbiome therapeutics;microbiota;microbiota profiles;Monitor;mortality;multidisciplinary;Multidrug-Resistant Tuberculosis;Mus;New York;Oral;Outcome;Pantoea;Parents;Pathogenesis;Pathway Analysis;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Physiological;Production;programs;Propionates;Prospective, cohort study;Province;Pulmonary Tuberculosis;Pyrazinamide;Regimen;Research;Research Priority;Research Support;resilience;Resistance;response;Rifampicin resistance;Rifampin;risk prediction;Sampling;Scientist;South Africa;South African;Sputum;Structure;Testing;Treatment outcome;treatment response;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Uncertainty;Universities;Volatile Fatty Acids;Withholding Treatment;Work

PROJECT_TITLE: Longitudinal microbiome-host interactions and clinical outcomes in drug-resistant tuberculosis patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-L(57)R]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative This research is relevant to public health as it seeks to co-design a family-based intervention to better address the opioid use treatment needs of a uniquely marginalized population of women affected by opioid use and criminal justice involvement. Effective intervention strategies for these women and their families are non- existent; therefore, the current study addresses this gap by adapting and pilot testing a family-based intervention, co-designed with members of these families to address their unique needs. This work is closely aligned with NIDA's strategic plan to fund research to improve opioid use treatment approaches implemented within criminal justice systems that support meaningful and sustained recovery among vulnerable and marginalized populations.

PI_NAMEs: MURNAN, AARON WILLIAM (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Aftercare;Ambulatory Care;Area;Award;Behavior Therapy;career;Child;college;community based participatory approach;community based participatory research;comorbidity;Conflict (Psychology);Criminal Justice;Data;Decision Making;Dedications;design;Discipline of Nursing;Diversion Program;Doctor of Philosophy;effective intervention;Enrollment;Environment;experience;Family;Family member;family support;feasibility trial;Feedback;Funding;Goals;group intervention;Health;health disparity;Health Promotion;Home;Homicide;improved;Individual;innovation;Intervention;Intervention Studies;Interview;Justice;Lived experience;Manuals;marginalization;marginalized population;medication for opioid use disorder;member;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Mothers;Motivation;National Institute of Drug Abuse;neglect;novel;Opioid;opioid epidemic;opioid use;opioid use disorder;Outcome;Outcome Measure;Overdose;Participant;Personal Satisfaction;pilot test;Population;Positioning Attribute;preference;Premature Mortality;Process;professor;programs;prospective;Prostitution;prototype;Public Health;Publishing;Randomized;Randomized, Controlled Trials;recidivism;Recording of previous events;Recovery;recruit;Relapse;Reporting;Research;Research Methodology;Research Personnel;response;Risk;satisfaction;Scientist;Seasons;sex;Site;skills;sobriety;Strategic Planning;substance use;substance use treatment;Support System;sustained recovery;System;tenure track;therapy development;Training;Trauma;treatment arm;Treatment outcome;Universities;Victimization;Violence;Vulnerable Populations;Woman;women's outcomes;women's treatment;Work

PROJECT_TITLE: A Unique, Co-Designed Family-Based Therapy for Marginalized Women with Opioid Use Disorder and Justice-Involvement

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: NARRATIVE – J. NRSA TRAINING CORE The TL1 program provides training for predoctoral and early-stage postdoctoral trainees to develop domain expertise, rigorous research, team science, and communication skills. The TL1 program addresses the NCATS need for a prepared translational research workforce. Project Narrative

PI_NAMEs: LEWIS, BRIAN C (contact)

PROGRAM_OFFICER_NAME: GANNOT, GALLYA

PROJECT_TERMS: Address;Administrative Supplement;Area;Biostatistical Methods;career;Characteristics;Clinical;clinical investigation;Clinical Research;clinical training;cohort;Collaborations;commercialization;Communication;Communities;community engagement;Competence;Contracts;Creativeness;Data Science;design;Development;Development Plans;disability;Discipline;Doctor of Philosophy;Ecosystem;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Effectiveness;Eligibility Determination;Emerging Technologies;Ensure;Entrepreneurship;Environment;Epidemiologic Methods;Ethnic Origin;Evaluation;experience;Exposure to;externship;Faculty;Flowers;Fostering;Foundations;Funding;General Practitioners;Goals;Gold;Grant;Group Meetings;Growth;hands on research;Health;implementation science;improved;Individual;Informatics;Institution;Instruction;interest;Internships;Knowledge;Learning;Link;Manuscripts;Master of Science;matriculation;Medical Students;member;Mentors;Methodology;Modeling;National Center for Advancing Translational Sciences;National Research Service Awards;new product development;Operative Surgical Procedures;Pathway interactions;Phase;Population;Positioning Attribute;Postdoctoral Fellow;pre-clinical;pre-clinical research;pre-doctoral;Process;Professional Organizations;programs;Protocols documentation;Publications;Qualifying;Race;recruit;Reproducibility;Research;Research Ethics;Research Personnel;Research Project Grants;Research Training;Resources;Rotation;Science;Scientific Inquiry;Scientist;Self Assessment;Series;skills;skills training;Structure;Student recruitment;Students;success;Surveys;symposium;synergism;System;Talents;Technical Expertise;TNFSF15 gene;tool;Training;Training Programs;translational pipeline;Translational Research;translational research program;translational scientist;United States National Institutes of Health;Vertebral column;Work;working group

PROJECT_TITLE: J: NRSA Training Core


NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Exfoliation syndrome (XFS) and the related glaucoma (XFG) is a leading cause of blindness world-wide. The etiology of XFS/XFG is poorly understood and effective means of primary prevention and curative therapies are not available. In this proposal, our collaborative group will complete studies to identify risk factors for XFS/XFG with the ultimate goal of developing effective screening and prevention strategies and novel therapies targeted to the molecular events responsible for the disease.

PI_NAMEs: KANG, JAE H;WIGGS, JANEY L (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Alleles;biobank;Biological;Blindness;case control;Cataract;Cataract Extraction;Cholesterol;Clinical;clinically relevant;Coffee;Collaborations;Complex;Consumption;Cortisone;cost;curative treatments;Data;Development;Diagnosis;Diagnostic;Disease;Ear;Environmental Exposure;Environmental Risk Factor;Epidemiology;Etiology;Event;Exfoliation Syndrome;exome;Eye;Folic Acid;Follow-Up Studies;Frequencies;Funding;Gene Expression;Genetic;Genetic Risk;genetic risk factor;genome wide association study;genomic locus;Genomics;Genotype;Glaucoma;Goals;Haplotypes;Health Professional;Individual;Intake;International;lipid mediator;Lipids;Lysophosphatidylcholines;Maps;Measures;Mediating;Mediation;Mediator;meetings;Mendelian randomization;Meta-Analysis;Metabolite Interaction;metabolomics;Molecular;Morbidity - disease rate;multidisciplinary;new therapeutic target;novel;novel therapeutics;Nurses' Health Study;Onset of illness;Participant;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phosphatidylethanolamine;Plasma;Plasmalogens;polygenic risk score;premature;Prevention strategy;Prevention therapy;Primary Prevention;prospective;protective effect;protein aggregation;Public Health Practice;residence;Risk;Risk Factors;risk variant;Sampling;Sampling Studies;screening;Sequence Analysis;Steroids;Time;Triglycerides;Ultraviolet Rays;Variant;Work

PROJECT_TITLE: Genetic and Environmental Risk Factors for Exfoliation Syndrome and Glaucoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-P(02)M]


NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE In multicellular organisms, stem cells play conserved roles in dictating organogenesis and sustaining body formation. Defects in stem cell function result in abnormal organ development and human diseases. Unraveling the regulatory mechanisms underlying stem cell function and homeostasis will advance biomedical applications and lead to effective cell-based therapies including tissue regeneration for human health.

PI_NAMEs: ZHOU, YUN  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: 3-Dimensional;Adenine;Animals;Apical;Arabidopsis;Biochemistry;Biological Models;cell behavior;Cell Communication;Cell Count;Cell Cycle;Cell Differentiation process;Cell division;cell fate specification;cell growth;Cell Physiology;Cell Therapy;cell type;Cells;Communication;Computer Models;confocal imaging;Cytokinins;daughter cell;Defect;Diabetes Mellitus;Disease;Exclusion;experimental study;Family;fluorescence imaging;Functional disorder;Future;gene function;Genes;Genetic;genetic approach;genetic resource;Genetic Transcription;Goals;Health;Heart Diseases;High-Throughput RNA Sequencing;Homeostasis;Hormones;Human;human disease;Image Analysis;imaging approach;Immobilization;in silico;In Vitro;in vivo;Knowledge;Lateral;Lead;live cell imaging;Meristem;Metabolism;Modeling;Molecular;Molecular Genetics;mutant;Nerve Degeneration;Organ;organ growth;Organism;Organogenesis;Pathway interactions;peptide hormone;plant growth/development;Plants;Play;Pluripotent Stem Cells;Proliferating;Proteins;Regulation;Reporter;Repression;Research;Role;self-renewal;Series;Side;Signal Transduction;stem cell fate specification;stem cell function;stem cell homeostasis;stem cell niche;stem cell population;stem cell proliferation;stem cells;Surface;System;Testing;Time;tissue regeneration;Undifferentiated;Work

PROJECT_TITLE: Molecular Mechanisms of Stem Cell Homeostasis in Arabidopsis

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]