ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: FORT WORTH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: Project Narrative Age-related neurodegenerative diseases like glaucoma have no cure and are a significant public health burden. Our research has shown that glaucoma is associated with loss of cellular energy that is amenable to metabolism-based intervention. Findings from this study will inform the development of novel therapeutics that manipulate cellular metabolism to prevent or slow the progression of glaucoma.

PI_NAMEs: INMAN, DENISE M (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Acceleration;age related neurodegeneration;Animals;Astrocytes;axonal degeneration;Biochemical;Bioenergetics;Cell Physiology;Cell Survival;cell type;Cells;Chronic;Complex;conditional knockout;Coupling;Data;Dependence;design;Detection;Development;Disease;Elements;Equilibrium;Etiology;functional decline;Functional disorder;Gene Expression;Gene Expression Regulation;gene repression;Genes;Glaucoma;Glycolysis;Goals;high intraocular pressure;Homeostasis;Human;human tissue;Hypoxia;in vivo;Incidence;Injury;innovation;insight;Intervention;Investigation;Knockout Mice;Maintenance;Mediating;Metabolic;Metabolic dysfunction;metabolic profile;Metabolism;metabolomics;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;Muller's cell;Nerve Degeneration;neural;Neuroglia;Neurons;new therapeutic target;novel therapeutics;Ocular Hypertension;Optic Disk;Optic Nerve;Oxidative Phosphorylation;Oxygen;Pathology;Perfusion;Physiologic Intraocular Pressure;Physiological;Positioning Attribute;prevent;protein expression;Public Health;Recycling;Regulation;Research;resilience;Retina;retinal ganglion cell degeneration;Retinal Ganglion Cells;Stress;stressor;Testing;Therapeutic Intervention;transcriptomics;Up-Regulation;Vision;Work

PROJECT_TITLE: Metabolic Vulnerability as a Diseased Target for Glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Drug Abuse (NIDA only);Emerging Infectious Diseases;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Vaccine Related

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NDRI-USA, INC.

ORG_STATE: NY

PHR: Project narrative  People who inject drugs (PWID) experience disproportionate risk of being infected with SARS-CoV-2, the virus that causes COVID-19, yet due to stigma, fear of mistreatment, and other factors, PWID are far less likely to be vaccinated compared to other populations. In response, we propose to continue our collaboration with a prominent community based organization serving African American and Latino PWID. Our project will explore baseline hesitancy to vaccinate among PWID, identify barriers to vaccination, and then develop and evaluate messaging designed to increase COVID-19 vaccination among our target population of PWID through a clinical trial.

PI_NAMEs: ARONSON, IAN DAVID (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: 2019-nCoV;Address;African American;Age;Area;automated text message;barrier to testing;Cellular Phone;Charge;Client;Clinical Trials;Collaborations;Communities;community advisory board;community organizations;Consult;cost;COVID-19;COVID-19 complications;COVID-19 impact;COVID-19 mortality;COVID-19 risk;COVID-19 vaccination;COVID-19 vaccine;Criminal Justice;Crowding;Data;Death Rate;design;Dose;Drops;Enrollment;Ensure;ethnic minority;Ethnic Origin;experience;Face;Feedback;follow-up;Fright;Gender;group intervention;Handwashing;Harm Reduction;health care availability;health disparity;health disparity populations;Hepatitis A;Hepatitis B Vaccination;HIV;HIV/HCV;Homelessness;improved;Individual;infection risk;Influenza vaccination;Injecting drug user;Intervention;intervention refinement;Interview;Language;Latino;Latino Population;Link;Location;maltreatment;Medical;Methods;New York;New York City;Outcome;Outcome Measure;overdose prevention;Participant;peer;Persons;Pharmaceutical Preparations;Phase;Population;Population Intervention;primary outcome;Race;racial minority population;Randomized;randomized, clinical trials;recruit;Research;Respondent;response;Risk;Sampling;SARS-CoV-2 infection;secondary outcome;Series;Shelter facility;Site;Social Distance;social stigma;Spanish;Spanish/English;Structure;substance use;Substance Use Disorder;Tablet Computer;Tablets;Target Populations;Technology;Testing;Text;Text Messaging;treatment duration;treatment group;Trust;Tuberculosis;United States;unvaccinated;uptake;Vaccinated;Vaccination;vaccine acceptance;vaccine access;vaccine hesitancy;Vaccines;ventilation;Virus;Water;Work

PROJECT_TITLE: Community Developed Technology-Based Messaging to Increase SARS-CoV-2 Vaccine Uptake Among People Who Inject Drugs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-G(90)S]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Urologic Diseases

ORG_CITY: NORFOLK

ORG_NAME: OLD DOMINION UNIVERSITY

ORG_STATE: VA

PHR: PUBLIC HEALTH RELEVANCE This project will investigate the impact of osteopontin-induced prostatic fibrosis on lower urinary tract dysfunction. Defining the molecular players contributing to prostatic fibrosis and how it relates to urinary dysfunction will provide new diagnostic and therapeutic targets to enhance the treatment of lower urinary tract symptoms in men.

PI_NAMEs: POPOVICS, PETRA  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 3-Dimensional;Age;Aging;Animal Model;Area;Autoimmune;autoimmune inflammation;Benign;Biological Assay;Biomedical Engineering;Bladder;Cancer Biology;career;career development;CD8-Positive T-Lymphocytes;Cell Communication;chemokine;Chronic;Clinical;clinical training;clinically significant;Coculture Techniques;Collagen;common symptom;cost;CXCL1 gene;cytokine;Data;Deposition;design;Detection;Deterioration;Development;Disease Progression;drug development;Economic Burden;Endocrinology;Environment;Epithelium;Estradiol;Extracellular Matrix;Familiarity;Fibronectins;Fibrosis;Functional disorder;Funding;Genetic;Goals;Healthcare Systems;IL6 gene;Immune;Immune response;immunopathology;Implant;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Inflammation;Inflammatory;Institution;Kidney;Knockout Mice;Knowledge;Link;Lower urinary tract;lower urinary tract symptoms;male;Mediating;Mediator;Medical;men;Mentors;Methods;Modeling;Molecular;Molecular Biology;Molecular Target;monolayer;Mus;new therapeutic target;novel;novel diagnostics;novel therapeutics;Organ;osteopontin;overexpression;Pathology;Pathway interactions;pharmacologic;Phosphoproteins;Physiological;Process;programs;Prostate;Prostatic;Prostatic Diseases;Prostatic Tissue;prostatitis;Proteins;public health relevance;Quality of life;Recovery;Reporting;Research;research and development;Research Personnel;Research Proposals;Role;Secondary to;Signal Transduction;skills;steroid hormone;Stream;Stromal Cells;subcutaneous;Symptoms;targeted treatment;Technology;Testing;Testosterone;Tissue Engineering;Tissues;Training;transmission process;urinary;Urination;Urology;Uropathogenic E. coli;Vocational Education

PROJECT_TITLE: Osteopontin: A Novel Mediator of prostatic inflammation and fibrosis


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Neurosciences;Nutrition

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Avoidant/restrictive food intake disorder (ARFID)—which affects 1-4% of adults—is a severe mental illness that causes people to eat an insufficient volume or variety of food and puts them at risk for nutritional deficiencies, low weight, psychiatric comorbidity, and suicidality. This multidisciplinary study offers an important opportunity to examine how underlying abnormalities in endocrine signalling and neural circuitry contribute to phenotypic presentations in adults. This innovative project has significant potential to reduce the public health burden of ARFID by informing pathophysiology and identifying mechanistic treatment targets hormonal agonist/antagonist medications and for brain stimulation therapies.

PI_NAMEs: HOLSEN, LAURA MCGRATH;LAWSON, ELIZABETH AUSTEN;THOMAS, JENNIFER JOANNE (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acute;Adolescent;Adult;Affect;Age;age group;Agonist;Allergic Reaction;Amygdaloid structure;antagonist;Anterior;Appetite Stimulants;Area Under Curve;Arousal;avoidant restrictive food intake disorder;Behavioral;behavioral phenotyping;Body mass index;Body Weight decreased;Brain;Central Nervous System;Child;Choking;Cholecystokinin;Chronic;cingulate cortex;Clinical;Clinical Psychology;cognitive system;cohort;Cues;Data;data archive;Dependence;dietary supplements;Dimensions;Disease;Distress;Eating;Eating Disorders;Endocrine;Evidence based treatment;Exhibits;experience;feeding;Feeling;Food;food restriction;Fright;Functional disorder;gastrointestinal;ghrelin;gray matter;Homeostasis;Hormonal;Hormones;Hydrocortisone;Hyperactivity;Hypothalamic structure;Impairment;Individual;innovation;Intake;interest;Interest Group;Intervention;Investigation;life span;Magnetic Resonance Imaging;Malnutrition;medical complication;men;Mental Health;Modeling;Motor Cortex;multidisciplinary;National Institute of Mental Health;Negative Valence;neural circuit;Neurobiology;Neuroendocrinology;neuroregulation;Neurosciences;novel;Oxytocin;Perception;Persons;Pharmaceutical Preparations;Phenotype;precision medicine;psychiatric comorbidity;psychosocial;Public Health;Reporting;Research;Research Domain Criteria;response;Risk;secondary analysis;Sensory Disorders;severe mental illness;Severities;sex;Signal Transduction;somatosensory;Somatosensory Cortex;Standardization;Stimulus;Stress;suicidal;Taste aversion;Time;Treatment outcome;Vegetables;Visual;Vomiting;Weight;Woman;Work;Youth

PROJECT_TITLE: Neurobiological Underpinnings of Avoidant/Restrictive Food Intake Disorder in Adults

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

PHR: This project aims to develop a new nanoplasmonic system capable of robust, multiplexed analysis of extracellular vesicles, emerging circulating biomarkers that can be harnessed by a non-invasive liquid biopsy. Successful completion of the project will produce a robust tool that will facilitate both basic research of extracellular vesicles and their clinical research use.

PI_NAMEs: IM, HYUNGSOON  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Basic Science;Binding;Biological;Biological Assay;Biosensing Techniques;Cells;circulating biomarkers;Clinical;clinical application;Clinical Research;Cytolysis;Development;Disease;extracellular vesicles;Genetic Materials;Goals;Heterogeneity;Individual;insight;Lipids;liquid biopsy;Liquid substance;Membrane;molecular diagnostics;Molecular Probes;nano;nanoplasmonic;nanoscale;new technology;noninvasive diagnosis;Periodicals;pre-clinical;Procedures;Process;Production;protein biomarkers;Proteins;Reproducibility;RNA marker;Sampling;sensor;Surface Plasmon Resonance;System;Technology;tool;transmission process;Vesicle

PROJECT_TITLE: Development of plasmon-enhanced biosensing for multiplexed profiling of extracellular vesicles

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative (Public Health Relevance) Given the rising burden of obesity, diabetes, and heart disease in the community, new approaches are needed to maintain blood vessel health from the impact of cardiometabolic traits. The proposed research investigates the impact of cardiometabolic diseases on health of the blood vessel lining cells, endothelial cells, by measuring stress markers and gene expression pathways. Our results will clarify how cardiometabolic diseases result in different patterns of endothelial cell gene expression and may identify novel molecular underpinnings of cardiovascular risk that will have important preventive and therapeutic implications.

PI_NAMEs: HAMBURG, NAOMI MIRIAM (contact);HO, JENNIFER E

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: Acceleration;Aging;Atherosclerosis;Automobile Driving;Bioinformatics;Biology;Blood Vessels;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;case control;Cell Line;clinical development;cohort;Communities;Diabetes Mellitus;Disease;Dwarfism;endoplasmic reticulum stress;Endothelial Cells;endothelial dysfunction;Endothelium;experience;experimental study;Framingham Heart Study;Gene Expression;Genetic Transcription;genomic biomarker;Health;Heart Diseases;Human;Individual;insight;Link;Measures;Metabolism;mitochondrial dysfunction;Molecular;multidisciplinary;multiple omics;Nitric Oxide;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;Obesity associated cardiovascular disease;Organelles;Participant;Pathway interactions;patient oriented research;Pattern;Phenotype;Population Sciences;premature;Prevalence;Preventive;programs;prospective;public health relevance;Research;Research Personnel;Resources;Risk Factors;Sampling;Signal Transduction;Stress;Therapeutic;trait;transcriptome sequencing;Vascular Diseases;Vascular Endothelium;Work

PROJECT_TITLE: Endothelial Cell Health Across the Spectrum of Cardiometabolic Disease

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ORG_CITY: MORGANTOWN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project narrative Tight regulation of coenzyme A (CoA), a cofactor that plays a key role in energy metabolism, is essential to maintain normal organ function and is achieved by balancing its synthesis and degradation. CoA degradation is a poorly characterized process and the research proposed herein will determine the importance of two CoA- degrading enzymes, NUDT19 and NUDT8, in the regulation of the CoA pools and CoA-dependent metabolic pathways within peroxisomes and mitochondria, respectively. This knowledge will establish the potential of targeting CoA-degrading enzymes to manipulate specific subcellular CoA pools and correct deranged metabolic processes with more selectivity.

PI_NAMEs: LEONARDI, ROBERTA  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Acyl Coenzyme A;acyl group;Biochemical;Biochemical Pathway;Cholesterol;Coenzyme A;cofactor;Cytosol;Development;Energy Metabolism;Enzymes;Exercise;fatty acid oxidation;Funding;genetic manipulation;Gluconeogenesis;Goals;histone modification;Kidney;Knowledge;lipid metabolism;Liver;Mammalian Cell;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Mitochondria;mitochondrial metabolism;Mus;Organ;Organelles;Pathway interactions;Performance;peroxisome;Play;Post-Translational Protein Processing;Postabsorptive Hypoglycemia;prevent;Prevention;Process;programs;Property;Publishing;Reaction;reduced muscle mass;Regulation;Renal function;Research;Role;Skeletal Muscle;Tissues

PROJECT_TITLE: Changes in Coenzyme A Levels are a Key Mechanism Regulating Metabolic Pathways


ADMINISTERING_IC: AI

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROGRAM NARRATIVE The CHEETAH Center for the Structural Biology of HIV Infection, Restriction and Viral Dynamics will be organized around: 1) three Scientific Projects that will advance our understanding of HIV-host interactions and provide the foundations for developing new therapeutic strategies for HIV treatment and cure, 2) three Scientific Cores that will advance and apply new technologies, 3) an Administrative Core that will coordinate Center activities and direct our Scientific Education, Public Outreach, and Molecular Animations, and 4) a Developmental Core that will engage and support the next generation of HIV structural biology researchers.

PI_NAMEs: SUNDQUIST, WESLEY I. (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Animals;animation;Architecture;Award;base;Biological Products;Biology of HIV Infection;biophysical properties;Biopolymers;Capsid;career;Cells;Complex;CRISPR screen;Cryoelectron Microscopy;design;Development;Education;Electrons;Ensure;Fluorescence Spectroscopy;Foundations;Genome;Goals;HIV;HIV-1;Human Resources;Image;In Situ;Infection;Innate Immune Response;instrumentation;Life Cycle Stages;Link;member;Methodology;Molecular;Monitor;new technology;next generation;novel therapeutic intervention;Nuclear;Nucleosome Core Particle;outreach;Peptide Synthesis;Production;programs;Protein Engineering;protein purification;Proteins;Proviruses;reconstitution;Research Personnel;Resolution;Reverse Transcription;Role;scaffold;Science;screening;Signal Transduction;Site;structural biology;Structure;synergism;System;Technology;Tissues;tool;Training Activity;TRIM Gene;Viral;Viral Physiology;viral rebound;Virus;visiting scholar;web site;X-Ray Crystallography

PROJECT_TITLE: CHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral Dynamics


PHR: CORE NARRATIVE This Core will enable CHEETAH investigators to visualize and follow the behavior of HIV-related complexes by using fluorescence spectroscopy to analyze structure and dynamics, antibody technology to facilitate 3D structure determinations, and electron cryotomography to visualize complexes in their native cellular environments.

PI_NAMEs: PUGLISI, JOSEPH D (contact)

PROJECT_TERMS: Antibodies;antibody mimetics;Behavior;Binding;Biological;Biological Process;biological systems;Biology of HIV Infection;Complex;Cryoelectron Microscopy;design;Electron energy loss spectroscopy;Electron Microscopy;Electrons;empowerment;Environment;Epitopes;Fluorescence;Fluorescence Spectroscopy;HIV;HIV-1;Hybrids;Image;imaging approach;instrumentation;Investigation;Ions;Label;light microscopy;Link;Macromolecular Complexes;Measures;member;Methodology;Methods;Microscopy;Molecular;Molecular Conformation;Nanotechnology;novel;novel strategies;particle;protein complex;Proteins;Reporter;Research Personnel;Resolution;RNA;RNA I;scaffold;single molecule;Site;spectroscopic imaging;Spectrum Analysis;structural biology;Structure;System;Technology;three dimensional structure;Time;tool;trafficking;Viral;Virus;Visualization;waveguide


PHR: CORE NARRATIVE This Core will provide access to state-of-the-art instrumentation and expertise in construct design, protein expression, biophysical characterization, X-ray crystallography, cryoEM, and training in biophysics and structural biology.

PI_NAMEs: HILL, CHRISTOPHER P. (contact)

PROJECT_TERMS: analytical ultracentrifugation;Bacterial Proteins;Binding;Biochemistry;Biological Assay;Biology;Biology of HIV Infection;biophysical properties;Biophysics;Calorimetry;Circular Dichroism;Collaborations;Complement;Complex;Computer software;computerized data processing;Cryoelectron Microscopy;Crystallization;Data;Data Collection;design;design and construction;Development;Experimental Designs;Fluorescence Polarization;Foundations;Growth;HIV;HIV-1;insight;instrumentation;Kinetics;Laboratories;macromolecule;member;Micro Electron Diffraction;Negative Staining;novel therapeutic intervention;particle;Process;Production;programs;protein expression;protein folding;protein purification;Proteins;Recombinants;Recording of previous events;Resolution;Resources;RNA;Robotics;Roentgen Rays;Role;Sampling;Scholars Program;screening;Services;small molecule;structural biology;Structure;success;Surface Plasmon Resonance;Synchrotrons;System;Techniques;Thermodynamics;Titrations;tool;Training;Universities;Utah;Validation;Viral;visiting scholar;X-Ray Crystallography


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

PHR: PROJECT NARRATIVE To establish a productive infection, HIV-1 must enter the cell, copy its RNA genome into DNA, enter the nucleus, and integrate into the host cell DNA. Studies in this Project will uncover currently unknown aspects of these different processes in molecular detail, providing a foundation for the identification and development of new anti-viral targets. We will also characterize how the potent new HIV-1 inhibitor, lenacapavir, binds the viral capsid and inhibits nuclear entry.

PI_NAMEs: BJORKMAN, PAMELA J (contact)

PROJECT_TERMS: 3-Dimensional;Architecture;Binding;Biological Assay;Biology of HIV Infection;Capsid;Cell Communication;Cell membrane;Cell Nucleus;Cell-Free System;Cells;Chromatin;Complementary DNA;Complex;Coupled;design;Development;dimer;DNA;DNA Integration;Docking;electron tomography;Electrons;experimental study;Exposure to;Fluorescence Microscopy;Foundations;Genome;genomic RNA;HIV-1;Host Factor 1 Protein;Image;In Situ;in vivo;Infection;inhibitor;Integration Host Factors;Knowledge;Learning;Life Cycle Stages;Macaca;Methods;Molecular;Molecular Conformation;novel;Nuclear;Nuclear Import;Nuclear Pore;Nucleosome Core Particle;Pathway interactions;Plastic Embedding;Process;Productivity;Proviruses;receptor;reconstitution;Replication Initiation;Resolution;Reverse Transcription;RNA;Role;Series;simian human immunodeficiency virus;Stains;structural biology;Structure;System;Systems Integration;Time;Tissue Sample;Transcription Initiation;transcriptional coactivator p75;Ubiquitin;Viral;viral DNA;viral genomics;Viral Reverse Transcription;viral RNA;Virus;Virus Integration;Visualization


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative: Human Pumilio proteins, PUM1 and PUM2, are essential proteins that control the flow of genetic information from genes to proteins. Defects in their function lead to neurological diseases including seizures, intellectual disability, and neurodegeneration. This proposal seeks to comprehensively understand their regulatory function and identify the genes they control.

PI_NAMEs: GOLDSTROHM, AARON CHARLES (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Binding;Biochemical;Biological Process;Biology;Cells;Data;Defect;Development;Disease;Enzymes;Functional disorder;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;genetic information;Human;human disease;in vivo;Infertility;insight;Intellectual functioning disability;Knowledge;Lead;Link;Malignant Neoplasms;Mediating;Messenger RNA;mitochondrial dysfunction;mRNA Transcript Degradation;Nerve Degeneration;Nervous System Disorder;Outcome;Pathogenesis;Prevalence;Process;Proteins;recruit;Repression;Research;Response Elements;RNA;RNA Decay;RNA Degradation;RNA Sequences;RNA-Binding Proteins;Role;Seizures;Structure;synergism;Translation Process;Translational Repression

PROJECT_TITLE: Translational Control by Human Pumilio Proteins

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PHR: PROJECT NARRATIVE Although the virus eventually wins in the absence of sustained antiretroviral treatment (ART), humans have an array of innate immune responses that help to limit HIV-1 replication, particularly during viral transmission and when the virus rebounds upon removal of ART. These observations imply that it might be possible to devise effective new antiviral therapeutic strategies if we better understood how innate immune factors sense and inhibit viral replication, and can learn better how to manipulate and harness these responses. The primary goal of this Project is therefore to gain such insights into innate immune factors that act at early steps in the HIV life cycle.

PI_NAMEs: PORNILLOS, OWEN  (contact)

PROJECT_TERMS: Affect;Anti-viral Agents;Anti-viral Response;antiretroviral therapy;APOCEC3G gene;Binding;Biological Assay;Biology of HIV Infection;Capsid;Cell-Free System;Cells;cofactor;Cryoelectron Microscopy;design;Detection;Dissociation;Excision;experimental study;Genetic;Goals;HIV;HIV-1;HIV/AIDS;Human;Immune;Immunologic Factors;In Vitro;Infection;inhibitor;Innate Immune Response;innate immune sensing;insight;Integration Host Factors;Interferons;Interruption;Learning;Life Cycle Stages;Lipid Bilayers;Lipids;Mediating;Membrane Fusion;Modeling;Molecular Conformation;Myeloid Cells;novel;Pathway interactions;phospholipid scramblase;pressure;Process;Proteins;Reaction;Recombinants;reconstitution;Regulation;response;Reverse Transcription;Role;Running;sensor;Serine;Signal Transduction;structural biology;Structure;System;Testing;Therapeutic;Transcript;transmission process;TRIM Gene;TRIM5 gene;Ubiquitination;Viral;Viral Physiology;viral rebound;viral transmission;Virion;Virus;Virus Replication


PHR: PROJECT NARRATIVE Research in this Project is designed to create the foundations necessary for developing treatments that could cure HIV patients, broadly protect animals against infection by enveloped viruses, and deliver biological therapeutics more effectively.

PI_NAMEs: MOTHES, WALTHER H (contact)

PROJECT_TERMS: Animal Model;Animals;Anti-Retroviral Agents;Anti-viral Agents;Architecture;Binding;Binding Sites;Biological;Biological Products;Biological Response Modifier Therapy;Biology;Biology of HIV Infection;Capsid;cell behavior;Cell Line;cell type;Cells;Collaborations;Complex;delivery vehicle;design;Development;Engineering;flexibility;Foundations;frontier;Gene Expression Profile;gene therapy;Generations;Genes;Goals;Heterochromatin;HIV;HIV-1;humanized mouse;Image;imaging approach;In Situ;Infection;Integral Membrane Protein;Knock-in;Knock-in Mouse;Knockout Mice;macromolecule;Medicine;Membrane;Membrane Fusion;Messenger RNA;Methods;Methyltransferase;Modeling;Molecular;Molecular Structure;Mouse Cell Line;mouse model;Mus;nanocage;nanomaterials;nanoparticle;new technology;next generation;nonhuman primate;particle;Pathway interactions;Patients;Protein Engineering;Proteins;receptor;recruit;Research;Resistance;Resolution;Scaffolding Protein;self assembly;SETDB1 gene;Shapes;Site;SIV;structural biology;Structure;success;System;technology platform;Testing;Therapeutic;Therapeutic Intervention;Transgenic Mice;Viral;viral rebound;Virus;Virus Diseases;Visualization


ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: Project Narrative The success of our R35 has resulted in the implementation of the XCMS-METLIN online informatic platform, an effort that has been decades in the making. This technology, especially with the incorporation of METLIN’s MS/MS data, is causing explosive growth in the number of registered users, now over 50,000. To support this growing user base, we request support for a more advanced server system with the primary purpose to leverage this new breakthrough technology.

PI_NAMEs: SIUZDAK, GARY E (contact)

PROGRAM_OFFICER_NAME: YUAN, JEAN

PROJECT_TITLE: Metabolomics Technologies to Advance Biomedical Research


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: MISSOULA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: PROJECT NARRATIVE Wolbachia bacteria are the most common endosymbionts in nature. Vector-control groups are attempting to establish pathogen-blocking Wolbachia strains in mosquito populations to reduce the transmission of human diseases, particularly dengue and Zika. This research will identify and evaluate the mechanisms that govern the spread and maintenance of Wolbachia in host populations.

PI_NAMEs: COOPER, BRANDON S. (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TITLE: The evolutionary genetics and genomics of Wolbachia effects on host physiology

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This administrative supplement will fund the central pharmacy and urine drug screening activities reassigned to Lead Investigators at Yale University and not previously supported in the original funded application described as follows. The emergency department (ED) provides an opportunity to care for patients with opioid use disorder (OUD) and initiate treatment 24 hours, 365 days a year. This project will test two dosing strategies of buprenorphine, standard ED dosing versus a high dose accelerated induction process, in engaging patients with ongoing addiction treatment while evaluating treatment engagement, craving, withdrawal symptoms and use of illicit drugs.

PI_NAMEs: D'ONOFRIO, GAIL  (contact);HAWK, KATHRYN ;HERRING , ANDREW

PROGRAM_OFFICER_NAME: DOBBINS, RONALD

PROJECT_TERMS: Acceleration;Accident and Emergency department;addiction;Administrative Supplement;Alcohols;analytical method;Buprenorphine;clinical trial enrollment;Clinical Trials;craving;Development;Diagnostic Reagent Kits;Dose;Double-Blind Method;Drug Screening;drug testing;Emergency Department patient;Enrollment;Ethnic Origin;Evaluation;fentanyl use;follow-up;Funding;Gender;Geography;Health Services Accessibility;Healthcare Systems;Helping to End Addiction Long-term;High Prevalence;Hour;housing instability;illicit drug use;illicit opioid;improved outcome;Individual;Insurance Coverage;Intervention;Lead;medication for opioid use disorder;mortality;multi-site trial;National Institute of Drug Abuse;Opioid;opioid agonist therapy;opioid use;opioid use disorder;opioid withdrawal;Outcome;Overdose;Participant;Patient Care;patient engagement;Patients;Pharmaceutical Preparations;Pharmacotherapy;Pharmacy facility;polysubstance use;primary outcome;Process;Prospective Studies;Protocols documentation;public health priorities;Race;Randomized;randomized, clinical trials;Research Personnel;Safety;Sampling Studies;sedative;Site;social health determinants;Stimulant;Surveys;Telephone;Testing;trial comparing;Universities;Urine;Visit;Withdrawal Symptom

PROJECT_TITLE: CTN145: Standard versus High Dose ED-Initiated Buprenorphine Induction Administrative Supplement 1


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Hematology;Prevention

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE Despite evidence-based clinical guidelines that recommend the use of VTE risk-stratification tools to identify ambulatory patients with cancer at high-risk of VTE who may benefit from VTE prevention with prophylactic anticoagulation, our preliminary data suggest that both risk assessment and primary prophylaxis are substantially underused. This study will use implementation science principles to develop, test, and evaluate an implementation strategy to increase the use of VTE risk assessment and, for high-risk patients, primary thromboprophylaxis. The long-term goal of the proposed research is to reduce VTE and improve outcomes for ambulatory patients with cancer.

PI_NAMEs: MARTIN, KARLYN  (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Adherence;Adoption;American;Anticoagulation;Applied Skills;Behavior Therapy;Behavioral;Cancer Patient;career;career development;Caring;Cause of Death;chemotherapy;Clinic;Clinical;clinical practice;Clinical Practice Guideline;Clinical Trials Design;cohort;Communities;Consolidated Framework for Implementation Research;contextual factors;Data;design;dissemination science;Education;Effectiveness;effectiveness evaluation;Event;evidence base;evidence based guidelines;Foundations;Funding;Future;Goals;Guidelines;Health Care Costs;Hematology;Hemorrhage;Hemostatic function;high risk;High-Risk Cancer;Hospitalization;implementation evaluation;implementation outcomes;implementation science;implementation strategy;improved;improved outcome;Incidence;International;K-Series Research Career Programs;Knowledge;Logic;Malignant Neoplasms;malignant stomach neoplasm;Measures;medical specialties;Mentored Patient-Oriented Research Career Development Award;Mentors;Meta-Analysis;Methods;Modeling;multimodality;National Comprehensive Cancer Network;Oncologist;Oncology;Outcome;pancreatic cancer patients;Patient Care;Patient-Focused Outcomes;Patients;Physicians;prevent;Prevention;Proctor framework;prophylactic;Prophylactic treatment;randomized trial;Randomized, Controlled Trials;Recommendation;Research;Research Methodology;Research Personnel;Risk;Risk Assessment;risk stratification;Scientist;screening;Site;Societies;Surveys;System;Testing;Thrombosis;tool;treatment as usual;tumor progression;uptake;usability;venous thromboembolism;Work

PROJECT_TITLE: Implementing Prevention of Venous Thromboembolism for Ambulatory Patients with Cancer (PREVenT-APC)

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative This research will increase knowledge about the regulation of gene expression, which underlies virtually every aspect of human health. By improving understanding of RNA polymerase, which is an established target for effective antibiotics, the work will aid in the quest for new antibiotics that can keep humankind a step ahead of microbial pathogens. The research also will elucidate complex connections between RNA synthesis by RNA polymerase, chromatin structure, RNA maturation, and RNA translation that are key to understanding the function of microbial communities in promoting both human health and disease.

PI_NAMEs: LANDICK, ROBERT  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Abbreviations;Actinobacteria class;Administrative Supplement;Affect;Amino Acids;Anti-sense RNA;Antibiotics;antimicrobial;Bacillus subtilis;Bacteria;Bacterial Chromosomes;Bacterial RNA;Bacteroides fragilis;Behavior;Biochemical;Biogenesis;Biological Assay;Biotechnology;C-terminal;Catalysis;Chromatin;Chromatin Structure;Chromosome Structures;Clostridium difficile;Closure by clamp;Complement;Complex;Consensus;Coupled;Coupling;Cryoelectron Microscopy;Disease;DNA;DNA Insertion Elements;DNA-Directed RNA Polymerase;ds-DNA;Elements;Escherichia coli;Eukaryota;Family;Filament;Firmicutes;Gene Expression Regulation;Gene Silencing;gene therapy;genetic approach;Genetic Transcription;genome-wide;Goals;Growth;Health;Hi-C;Human;improved;In Vitro;in vivo;insight;Interferometry;Knowledge;Link;Mediating;Medicine;Methods;Microbe;microbial community;Modeling;Molecular;Molecular Biology;Molecular Chaperones;Molecular Conformation;Molecular Structure;mycobacterial;Mycobacterium tuberculosis;N-terminal;Nucleoproteins;Nucleotides;paralogous gene;pathogenic microbe;Positioning Attribute;premature;Prokaryotic Cells;Proteobacteria;recruit;Regulation;Reporter;Research;Ribosomes;RNA;RNA chemical synthesis;RNA Folding;Role;Rotation;Signal Transduction;single molecule;Spectrum Analysis;Structure;System;Transcription Elongation;transcription factor;Transcriptional Regulation;Translations;Triplet Multiple Birth;virtual;Work;Y protein

PROJECT_TITLE: Administrative Supplement: Structure/Function of Transcription Complex Regulation

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Genetics

PHR: PROJECT NARRATIVE Studies from the last several years have highlighted the importance of long noncoding RNAs in human development, health, and diseases such as cancer and atherosclerosis, but the mechanisms by which RNAs effect epigenetic change remain largely unknown. X-chromosome inactivation serves as an excellent model to study RNA regulation because this process is controlled by a series of RNA-based switches. Our proposed research will dissect mechanisms of RNA regulation by investigating its role in chromosome pairing, gene silencing, and imprinting.

PI_NAMEs: LEE, JEANNIE T (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Alleles;Atherosclerosis;autosome;Biology;career;Cell model;Chromosome Pairing;Complex;decapping enzyme;Development;Disease;Elements;Embryo;Epigenetic Process;Funding;Gene Silencing;Genes;Germ Lines;Health;Human Development;imprint;Learning;Link;male;Malignant Neoplasms;Meiosis;Modeling;mRNA decapping;Mus;neuronal cell body;Paint;Pathway interactions;permissiveness;Placenta;Postdoctoral Fellow;Process;Pseudoautosomal Region;recruit;Regulation;Research;RNA;Role;Series;Sex Chromosomes;Titrations;Training;Untranslated RNA;Work;X Chromosome;X Inactivation

PROJECT_TITLE: Regulation of X-chromosome inactivation and imprinting by non-coding elements


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Microbiome;Nutrition;Prevention

ORG_CITY: FARMINGTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: PROJECT NARRATIVE The liver is now recognized as an immunological organ with unique immunological properties; the liver’s immune response is tightly controlled and leads to immune tolerance to microbial and metabolic stimuli. Here, we have identified that high-fat high-sugar diet (HFS) and gut microbiota interaction generates a spectrum of dietary and microbial components and outcome metabolites that induce inappropriate hepatic immune activation and inflammation, contributing to the development of nonalcoholic fatty liver disease (NAFLD) from simple steatosis to the advanced form of non-alcoholic steatohepatitis (NASH). We propose to dissect the underlying cellular and molecular mechanisms to advance our understanding of the role of the Diet-Gut-Liver axis in hepatic immunity.

PI_NAMEs: LI, GUANGFU  (contact);RECTOR, RANDY SCOTT;STAVELEY-O'CARROLL, KEVIN FINNBAR

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Address;Advanced Development;Affect;Agonist;Antibiotics;Bacteria;Choline;Choline Deficiency;clinically relevant;commensal bacteria;cytokine;Data;Development;Diet;dietary;Drug Metabolic Detoxication;dysbiosis;Ensure;experimental study;Fatty acid glycerol esters;feeding;G-Protein-Coupled Receptors;global health;gut dysbiosis;gut microbiota;gut-liver axis;Hepatic;Hepatic Stellate Cell;High Fat Diet;Human;Imipenem;Immune;immune activation;Immune response;Immune Tolerance;Immunity;Immunologics;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;intrahepatic;intravenous administration;Knowledge;Kupffer Cells;Lipase;Lipids;Liver;Liver Cirrhosis;liver development;Liver diseases;liver inflammation;Macrophage;Malignant neoplasm of liver;Mediating;Mediation;Mediator;Metabolic;metabolomics;Metagenomics;Microbe;microbial;Modeling;Molecular;monocyte;Mus;Neomycin;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Nutrient;Organ;Outcome;Pathogenesis;Pathologic;Patients;Phenotype;Population;Portal vein structure;Positioning Attribute;Preventive;Production;Proliferating;Property;Reaction;Research Personnel;response;Risk Factors;Role;Shapes;Signal Pathway;Signal Transduction;simple steatosis;Stimulus;sugar;Testing;Therapeutic;Therapeutic Intervention;treatment response;Vancomycin;western diet;Wild Type Mouse

PROJECT_TITLE: Mechanisms of gut microbiota/metabolite interface-mediated hepatic inflammation

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Intellectual and Developmental Disabilities (IDD)

ORG_CITY: Boulder

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: NARRATIVE  The goal of this training grant is to prepare the next generation of scientists who will conduct high quality research and make new discoveries in biomedical sciences. The research focus of students who train in our program is to understand fundamental mechanisms in signaling and cellular regulation, an area which is key to the discovery of new therapeutic treatments for human diseases such as cancer, diabetes, inflammation, heart disease, immunological and neurological disorders, and birth defects, and forms a foundation for modern research in biology and medicine. The purpose of this INCLUDE supplement application to the existing parent T32 program is to enhance the robust environment for training graduate students in scientific areas that are relevant to alterations observed in Down syndrome and its co-occurring conditions.

PI_NAMEs: AHN, NATALIE G. (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: cell growth regulation;Down's Syndrome;pre-doctoral;Signal Transduction;Training

PROJECT_TITLE: Predoctoral Training in Signaling in Cellular Regulation (T32) INCLUDE Down Syndrome Supplement


NIH_SPENDING_CATS: Atherosclerosis;Autoimmune Disease;Cardiovascular;Clinical Research;Health Services;Heart Disease;Lupus;Pediatric;Prevention;Women's Health Research

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Lupus is one of the top 10 leading causes of non-accidental death in adolescent females. Children and adolescents with lupus develop early blood vessel injury that significantly increases their risk of early heart attacks and strokes in adulthood. We currently do not know how to monitor or prevent these changes in childhood-onset lupus, which is more severe and confers greater cumulative tissue damage than adult-onset lupus. The proposed project seeks to determine whether blood pressure patterns and blood vessel function can be used to evaluate vascular health in children with lupus, and to assess whether medications used to prevent heart disease in other conditions may be beneficial in adolescents and young adults with lupus.

PI_NAMEs: CHANG, JOYCE CHUN-LING (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Adolescent;Adolescent and Young Adult;Adult;Ambulatory Blood Pressure Monitoring;Atherosclerosis;Blood Pressure;Blood Vessels;Cardiology;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cessation of life;Child;Childhood;Chronic;clinical epidemiology;Data;Databases;Development;Early identification;Electronic Health Record;endothelial dysfunction;Endothelium;Event;experience;Female Adolescents;Fostering;Health;health assessment;heart disease prevention;high risk;Immunosuppression;improved;Infection;Inflammation;Injury;Intervention;Intervention Studies;longitudinal, prospective study;Lupus;Master of Science;Measures;Mediating;Mentors;Methods;Monitor;multidisciplinary;Myocardial Infarction;Non-accidental;Onset of illness;Outcome;Outcome Measure;Outcomes Research;patient oriented research;Pattern;Pediatric Hospitals;Pennsylvania;Peripheral;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacologic;Philadelphia;premature atherosclerosis;prevent;Prevention;professor;prospective;recruit;Renin-Angiotensin System;Research;Research Personnel;Resources;Rheumatism;Rheumatology;Risk;Risk Marker;Role;Stroke;Systemic Lupus Erythematosus;Testing;Tissues;Training;Universities;Work;young adult

PROJECT_TITLE: Cardiovascular health assessment & outcomes of systemic lupus erythematosus: bridging pediatric and adult- onset disease

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: HOUSTON

ORG_NAME: RICE UNIVERSITY

PHR: PROJECT NARRATIVE Mitochondria undergo constant surveillance, integrating a variety of signals into a cohesive feedback program that coordinates with the nucleus to ensure prompt homeostatic rebalancing critical for optimal mitochondrial function and cellular health. My lab has been instrumental in studying mitochondrial surveillance, with a particular focus on the ESRE network and its interactions with other protective mechanisms. Identifying the relationship between mitochondrial damage and changes in lipid homeostasis, propagation of the ESRE-activating signal to the nucleus, and how changes in RNA metabolism are coordinated to ensure a prompt response will help identify methods to promote improved health across the human lifespan.

PI_NAMEs: KIRIENKO, NATASHA  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acute;Administrative Supplement;Aging;alcohol exposure;alcohol response;Apoptosis;Binding;Biochemical;Biochemical Process;Bioenergetics;Biological;biological adaptation to stress;Cardiovascular Diseases;Cell Death;Cell Nucleus;Cells;Chronic Disease;Ensure;equipment acquisition;extend lifespan;Feedback;gene conservation;Gene Expression;Genes;Genetic;Health;Homeostasis;Human;improved;interest;life span;Lipids;Malignant Neoplasms;MED15;Mediator;Metabolic Diseases;Methods;Mitochondria;Mitochondrial Proteins;Neurodegenerative Disorders;Nucleotides;Organelles;overexpression;Pathway interactions;Play;Production;programs;promoter;Protein Import;Proteins;proteostasis;Reactive Oxygen Species;Regulation;response;Response Elements;RNA metabolism;Role;Signal Transduction;Small Nucleolar Ribonucleoproteins;Stress;Techniques;transcription factor;Translating;Up-Regulation

PROJECT_TITLE: Administrative Supplements for Equipment Purchases for R35GM129294 Regulation of mitochondrial surveillance


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Climate-Related Exposures and Conditions;Clinical Research;Contraception/Reproduction;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Exposure to air pollution during pregnancy is a leading environmental hazard of concern, with exposure during the prenatal period linked to postnatal health effects ranging from respiratory, cardiometabolic, and neurodevelopmental outcomes. As the organ that shapes the gestational experience of the developing fetus, the placenta is a pivotal, yet understudied, resource to provide critical insight into the toxicological responses to prenatal air pollution exposure. This study will evaluate the cellular and extracellular vesicle profiles of placental miRNA in response to traffic-related air pollutant exposure in a trophoblast cell culture model.

PI_NAMEs: HERBSTMAN, JULIE BETH (contact);MASON, CHRISTOPHER EDWARD;WU, HAOTIAN

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Adult;Air Pollutants;Air Pollution;Animals;Area;Biological;Blood Circulation;burden of illness;Carbon Black;cardiometabolism;Cell Culture Techniques;Cell Line;cell type;Cells;Child;Communication;Development;developmental toxicity;Diesel Exhaust;Disease;Dose;Endocrine;Ensure;Environmental Exposure;Environmental Hazards;Environmental Health;epitranscriptome;epitranscriptomics;Evaluation;experience;Exposure to;extracellular vesicles;Fetal Development;Fetal Growth;fine particles;Gene Expression Profiling;Genes;genome-wide;graduate student;Growth;Health;Human;In Vitro;insight;interest;Intervention;Link;Master of Public Health;Mediator;Messenger RNA;Meta-Analysis;meter;MicroRNAs;Modeling;Molecular;molecular phenotype;Molecular Profiling;neurotoxicity;Nitrogen Dioxide;novel;Observational Study;Organ;Outcome;parent grant;Parents;particle;Pathology;Pathway interactions;Placenta;Play;pollutant;Populations at Risk;Post-Transcriptional RNA Processing;postnatal;Pre-Eclampsia;Predisposition;Pregnancy;Pregnancy Complications;prenatal;prenatal exposure;Process;Regulation;Research;Resources;respiratory;response;RNA;Role;Series;Shapes;Specific qualifier value;Surveys;Therapeutic;Tissues;Toxicology;traffic-related air pollution;training opportunity;Training Support;Transcript;Transcriptional Regulation;transcriptome;transcriptome sequencing;trophoblast;Untranslated RNA

PROJECT_TITLE: Assessing effects of air pollution exposure on trophoblast cell mRNA and EV miRNA expression.


NIH_SPENDING_CATS: Natural Products

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative  The central objectives of this application are: (a) to develop new, reliable, and efficient, methodologies that enable the construction of stereochemically rich scaffolds and (b) to achieve the concise chemical syntheses of naturally occurring small molecules that possess intricate chemical structures. The results of these efforts should lead to the development of new strategies and tools for the preparation of various molecules of importance, including medicines.

PI_NAMEs: GARG, NEIL K (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Exploiting Unconventional Building Blocks in Chemical Synthesis


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Hematology;Infectious Diseases;Sepsis

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Contact PD/PI: Rosengart, Matthew R PROJECT NARRATIVE  Our group seeks to understand why and how some patients, even after being ‘healed’ and discharged from the hospital, continue to suffer poor health and a high rate of long-term death. Our characterization of how the mitochondrion restructures itself as an adaptive mechanism to mitigate the acute insult and ‘learn’ so as to protect the cell against any future environmental threat may provide a biological explanation for the elevated long-term death experienced by our patients. Together our results will provide foundational knowledge to support the development of innovative diagnostic tools and novel biologic therapeutics that compliment contemporary sepsis care to improve survival. In doing so we will address one of the most pressing needs in the care of septic patients. Project Narrative Page 7

PI_NAMEs: ROSENGART, MATTHEW RANDALL (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute;Administrative Supplement;American;Biological;Biological Response Modifier Therapy;Biology;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;Calcium Signaling;calcium uniporter;Caring;cell injury;Cell Respiration;Cells;Cessation of life;Chronic Obstructive Pulmonary Disease;Complex;Cytoprotection;Development;diagnostic tool;Equilibrium;experience;Family member;fitness;Future;Generations;healing;Health;Heart failure;Homeostasis;hospital readmission;Hospitalization;Hospitals;Human;Impaired cognition;improved;Infection;innovation;intraperitoneal;Knowledge;Learning;Lower respiratory tract structure;Lysosomes;Mediating;Metabolism;Mitochondria;Modeling;mortality;mouse model;multicatalytic endopeptidase complex;Mus;Myocardial Infarction;neurocognitive disorder;novel;Organism;Patients;Phenotype;preservation;protein degradation;Recurrence;response;Sampling;Sepsis;septic patients;Stress;Stroke;Survivors;Tissues;Work

PROJECT_TITLE: Administrative Supplement: Calcium homeostasis and cellular fitness in sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Brain Disorders;Dementia;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative The goal of this project is to develop a deeper understanding of the structure and function of proteins that contribute to the Transmissible Spongiform Encephalopathies and Alzheimer’s disease.

PI_NAMEs: MILLHAUSER, GLENN L (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Alzheimer's Disease;Amplifiers;Amyloid beta-Protein;Anatomy;Binding;Binding Proteins;Binding Sites;Biochemical;biophysical techniques;Biophysics;Brain;Cell surface;Cells;Central Nervous System;Copper;Creutzfeldt-Jakob Syndrome;cytotoxicity;Dementia;Disease;Emergency Situation;Endocytosis;Exhibits;Fatal Familial Insomnia;Functional disorder;Glycoproteins;glycosylation;Goals;Grant;Inherited;Ions;Kuru;Label;learning strategy;Maps;Membrane;Membrane Proteins;Metal Ion Binding;Metals;Methods;Mitochondria;Molecular;monomer;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neurotoxicity;Pathway interactions;Peptides;Peripheral;Polysaccharides;Prion Diseases;Process;programs;protein function;protein structure;protein transport;Proteins;PrP;PrPSc Proteins;pyruvate carrier;receptor;Research;Research Project Summaries;Role;Scrapie;Stress;Structure;Surface;Thermodynamics;Tissues;voltage;Zinc

PROJECT_TITLE: Supplement Request for Emergency Replacement of EPR Amplifier and Acquisition of a Low Volume Resonator for Membrane Proteins


ORG_CITY: College Station

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

PHR: Fragment-based screening promised to make the discovery and development of small molecule therapeutics more efficient and effective. The inherently weak binding of fragments is unfortunately incompatible with current discovery methods. NMR spectroscopy of proteins encapsulated in reverse micelles is being developed to overcome this limitation and thereby permit a fuller realization of the potential of fragment-based drug discovery.

PI_NAMEs: WAND, A. JOSHUA (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Affinity;automated analysis;Binding;Binding Sites;Biological Assay;Biology;Bioreactors;Catalogs;Characteristics;Chemicals;Complex;cost;cost effective;Creativeness;Crystallography;Data;design;Detection;detection limit;detection method;Development;Dissociation;drug development;drug discovery;drug-like compound;Elements;Encapsulated;Ensure;Entropy;Equilibrium;Ethane;experimental study;flexibility;Goals;Grant;high throughput screening;improved;Individual;innovation;insight;Interleukin-1 beta;Isotope Labeling;Lead;Libraries;Ligand Binding;Ligands;Link;Liquid substance;Membrane Proteins;meter;Methods;Micelles;Molecular Structure;nanoscale;National Institute of General Medical Sciences;Natural Products;NMR Spectroscopy;parent grant;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Preparation;Program Development;programs;Propane;Protein NMR Spectroscopy;Proteins;Resources;Sampling;screening;Site;small molecule;small molecule libraries;small molecule therapeutics;Surface;surfactant;Technology;technology research and development;Testing;tool;tool development;Uncertainty;Validation;Water;Work

PROJECT_TITLE: Improving Fragment Based Drug Discovery and the Development of Tools for Chemical Biology through Nanoscale Encapsulation and NMR Spectroscopy

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative The proposed project seeks to determine best practices for recruiting and engaging women living in the Deep South who are vulnerable to HIV infection into a digital cohort, with the goal of evaluating factors that contribute to STI and HIV acquisition and HIV pre-exposure prophylaxis use. Among a subset of women, we will assess feasibility and acceptability of collecting alcohol biomarkers. This project is responsive to national priorities outlined by the Ending the HIV Epidemic initiative as well as the National Institute of Allergy and Infectious Diseases and the National Institute of Alcohol Abuse and Alcoholism.

PI_NAMEs: ELOPRE, LATESHA ELLEN (contact);MATTHEWS, LYNN T

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Administrative Supplement;AIDS prevention;Alabama;Alcohol abuse;Alcohol consumption;Alcoholism;Alcohols;arm;Behavior;Biological Markers;biomarker evaluation;Black American;black women;Blood;Camellia sinensis;Centers for Disease Control and Prevention (U.S.);Child;Chlamydia;cis-female;cohort;Collaborations;Color;Communicable Diseases;Communities;community advisory board;community engaged research;community partners;Consent;Consolidated Framework for Implementation Research;Criminal Justice;Data;Deep South;design;Development;Diagnosis;digital;Disparity;Dryness;Enrollment;Epidemic;Epidemiology;Ethanol;evidence base;experience;Exposure to;Funding;Future;Geography;Goals;Gonorrhea;Health;Health protection;high risk;Hispanic Americans;Hispanic Women;HIV;HIV diagnosis;HIV Infections;Home;Incidence;Individual;Inequity;Infection;infection risk;innovation;Institutionalization;Interview;Light;Link;Literature;Longitudinal Studies;Measures;Methodology;Mobile Health Application;multidisciplinary;National Institute of Allergy and Infectious Disease;National Institute on Alcohol Abuse and Alcoholism;North Carolina;Outcome;Parents;Participant;Patient Self-Report;Pattern;phosphatidylethanol;Population;population based;Poverty;pre-exposure prophylaxis;Pregnancy;primary outcome;Public Health;Qualitative Methods;racism;Recommendation;Recording of previous events;recruit;Research;Research Personnel;Risk;Screening procedure;sex;Sexual Health;Sexual Partners;Sexually Transmitted Diseases;social disparities;social stigma;Southeastern United States;Spottings;substance use;Surveys;Syphilis;System;Testing;tool;Touch sensation;transgender women;trend;United States;Universities;Unsafe Sex;Update;uptake;Visit;Vulnerable Populations;White Women;Whole Blood;Woman;Women's cohort;women's diagnosis;women's prevention;Work

PROJECT_TITLE: CAMELLIA Cohort: A longitudinal study to understand sexual health and prevention among women in Alabama


PHR: Project Narrative The development of versatile and practical methods for organic synthesis is critical to the discovery and manufacture of molecular structures relevant to understanding biological mechanisms and treating human disease. In this proposal, we will pursue the design of new reactions and elucidation of fundamental reactivity principles in the areas of Ni-catalyzed cross coupling and phosphoranyl radical catalysis. In so doing, this research will provide new tools for the selective and efficient preparation of biologically relevant small molecules from simple and abundant starting materials.

PI_NAMEs: DOYLE, ABIGAIL GUTMANN (contact)

PROJECT_TERMS: Academia;Address;Adopted;Alcohols;Architecture;Area;Biological;biological preparation;Carbon;Catalysis;catalyst;chemical reaction;Chemical Structure;Chemicals;Chemistry;community engagement;Complex;Coupling;design;Development;drug candidate;Drug Industry;Electrons;Funding Mechanisms;Goals;graduate student;human disease;Hydrogen Bonding;improved;Instruction;invention;Laboratories;Life;Ligands;manufacture;Medicine;Methods;molecular manufacturing;Molecular Structure;Nickel;novel;Organic Synthesis;oxidation;Oxidation-Reduction;Phosphines;Postdoctoral Fellow;Process;programs;Property;Reaction;Research;Research Assistant;Research Personnel;Route;Site;small molecule;Structure;System;tool;Training;Transition Elements;undergraduate research;Visible Radiation;Work

PROJECT_TITLE: New Directions in Nickel and Photoredox Catalysis


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: Narrative A vaccine that will be effective in preventing HIV infection and also control virus replication once the virus has taken hold, will require a dual barrier. The first one at the mucosal portal of entry for the virus to prevent or at least minimize the ability of the virus to create a beachhead and two at the systemic level where generalized immune responses are able to control virus that has succeeded in overcoming the first barrier. Our vaccine strategy targets renewable vaginal epidermal stem cells as a permanent source of antigen production which proliferate and elaborate the vaccine antigen along the phases of the reproductive cycle, providing repeated bouts of vaccine antigen presentation as the cells mature and cycle, leading to induction of humoral and cellular immune responses.

PI_NAMEs: GAUDUIN, MARIE-CLAIRE ELISABETH (contact);VILLINGER, FRANCOIS J

PROGRAM_OFFICER_NAME: BOGGIANO, CESAR AUGUSTO

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Animals;Anti-viral Response;Antibodies;Antigen Presentation;Antigens;Attenuated;Attenuated Vaccines;Biopsy;Cells;chronic infection;clinical efficacy;Clinical Trials;Cross-Priming;Curiosities;Cytomegalovirus;Data;Daughter;Development;Dose;draining lymph node;efficacy study;epidermal stem cell;Epithelial Cells;epithelial stem cell;Epithelium;Female;female reproductive tract;follow-up;Genome;Histologic;HIV;HIV Infections;HIV vaccine;HIV/SIV vaccine;Human;immune clearance;Immune response;Immune system;Immune Targeting;Immunization;Immunologic Stimulation;ImmunoPET;improved;in vivo;Infection;Infection Control;infection risk;involucrin;keratinocyte differentiation;Lentivirus;Lentivirus Vector;lymphoid organ;Macaca;Macaca mulatta;Manuscripts;Measures;Modeling;Modification;Monkeys;Mucosal Immune Responses;mucosal site;Mucous Membrane;mutant;novel vaccines;offspring;pathogen;Pathogenicity;Penetration;Phase;Positron-Emission Tomography;preclinical trial;Preparation;prevent;Production;Proliferating;promoter;Proteins;Rectum;Recurrence;reproductive;Resolution;response;Risk;Safety;Site;SIV;SIV Vaccines;Solid;Source;Stimulus;Stratum Basale;System;T cell response;T-Lymphocyte;Testing;Time;time use;Tissues;Transfection;Translating;Translations;transmission process;Vaccinated;Vaccination;vaccination strategy;Vaccine Antigen;vaccine delivery;vaccine platform;vaccine strategy;Vaccinee;Vaccines;Vagina;vector vaccine;Viral;Viral Antigens;viral transmission;Viral Vector;Virus;Virus Replication;Visualization

PROJECT_TITLE: Durable HIV Vaccine Targeting Mucosal Epithelium

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Narrative: The looming crisis of antibiotic resistance and thus the inability to treat common infections is reaching a tipping point making development of new antibiotics imperative. Our parent U 19 grant has aimed to identify new targets that can be exploited to develop antibiotic-sparing therapies. This supplement proposal will explore the folding mechanism of the FimD usher, a key component of the type I chaperone usher pathway (CUP) pilus system that is critical for human cystitis, by the β-barrel Assembly Machinery (BAM). Furthermore, outcomes from this proposal will provide insight into key steps that can be exploited and targeted for therapeutic development.

PI_NAMEs: HULTGREN, SCOTT J. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Adhesives;Amino Acids;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Antimicrobial Resistance;Bacteria;Bacterial Adhesins;Bacterial Drug Resistance;Bacterial Infections;benzoylphenylalanine;beta barrel;beta pleated sheet;Binding;Biochemical;Biogenesis;Biological Assay;C-terminal;Cell Culture Techniques;Cells;Cessation of life;combat;Combating Antibiotic Resistant Bacteria;Complex;crosslink;Cystitis;Data;Development;Diagnosis;Engineering;Environment;Erythromycin;Escherichia coli;Exhibits;experimental study;Family;Fiber;Foundations;Funding;Future;Goals;Gram-Negative Bacteria;Grant;Growth;Human;Hybrids;Infection;inhibiting antibody;innovation;insight;Integration Host Factors;Interdisciplinary Study;Length;Mediating;Membrane;Membrane Proteins;Molecular Chaperones;Monitor;Monoclonal Antibodies;Mus;Mutagenesis;N-terminal;novel antibiotic class;novel strategies;Outcome;parent grant;Parents;Pathogenesis;Pathway interactions;periplasm;Pilum;Play;prevent;Process;programs;Proteins;Public Health;public health intervention;Research Design;residence;Resistance;Role;System;targeted treatment;Testing;Therapeutic;therapeutic development;Time;Tissues;Training;ultraviolet irradiation;unnatural amino acids;Uropathogenic E. coli;Usher Syndrome Type 1;Vancomycin;Variant;Virulence Factors;Western Blotting;Work

PROJECT_TITLE: Innovative Strategies to Combat Antibiotic-resistant Infections


PI_NAMEs: YODER, BRADLEY K. (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH


NIH_SPENDING_CATS: Neurosciences

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative (parent award) Inositol 1,4,5-trisphosphate receptors (IP3Rs) are calcium channels that are ubiquitously expressed in all eukaryotic cells and play important roles in regulation of a broad range of physiological processes in humans. Dysfunctions in IP3Rs are associated to numerous human diseases, including neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s diseases, stroke, and cancer, and therefore these channels are important drug targets. The proposed studies aim to understand the detailed structure and fundamental mechanisms governing IP3R channel function and to elucidate how they are perturbed in disease states that will aid in search for novel therapies to treat disorders related with abnormal cell calcium homeostasis.

PI_NAMEs: SERYSHEVA, IRINA I (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Abnormal Cell;Address;Administrative Supplement;Affect;Alzheimer's Disease;Architecture;Binding;Biochemical;Biophysics;Calcium;Calcium Channel;Calcium Signaling;Cell Physiology;Coupled;Cryoelectron Microscopy;deep neural network;Development;Disease;Drug Targeting;Electrophysiology (science);Endoplasmic Reticulum;Ensure;Eukaryotic Cell;extracellular;Family;Functional disorder;Homeostasis;Human;human disease;Huntington Disease;Image;inorganic phosphate;Inositol;insight;interdisciplinary approach;Ions;ITPR1 gene;Knowledge;Ligand Binding;Ligands;Malignant Neoplasms;Mediating;Membrane;Methods;Molecular;Molecular Conformation;Motion;Mutagenesis;Neurodegenerative Disorders;Neurons;novel therapeutics;parent project;Parkinson Disease;Pathologic;Physiological Processes;Play;Process;programs;Property;Protein Isoforms;Proteins;receptor;Regulation;Research;Resolution;Role;Shapes;Signal Pathway;Signal Transduction;Stimulus;Stroke;Structure;Work

PROJECT_TITLE: Administrative Supplement: Mechanisms of inositol trisphosphate receptor-mediated calcium signaling


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE This supplement requests funds to upgrade the computer infrastructure of the Scalable Informatics for Biomedical Imaging Studies (SIBIS), which is used by the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study for data acquisition, management, quality control, harmonization, analysis, and distribution to the public. The goal of NCANDA is to follow youth who have and have not engaged in hazardous drinking to determine alcohol's influence on the brain, cognition, emotion, and life activities in emerging adulthood when young men and women are establishing themselves in careers, relationships, and independent living. Upgrading the over 10-year-old computer infrastructure of SIBIS will enable us to maintain its high level of software security and fulfil the computational and storage needs of NCANDA so that NCANDA can continue with thoroughly tracking its participants, whose longitudinal data are critical to better understand how heavy alcohol drinking during adolescence impacts this period of life and adult functioning.

PI_NAMEs: PFEFFERBAUM, ADOLF ;POHL, KILIAN MARIA (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: 10 year old;Abstinence;Administrative Supplement;Adolescence;Adolescent;adolescent binge drinking;Adult;Adverse effects;Affective;Age;Alcohol consumption;alcohol cue;alcohol effect;alcohol expectancy;alcohol use initiation;Alcohols;Behavioral;binge drinking;Biological;biomedical informatics;Brain;career;Clinical;Clinical assessments;Cognition;Cognitive;cognitive control;cognitive performance;cohort;Collection;Communities;computer infrastructure;Computer software;Computer Systems;Computers;COVID-19 impact;COVID-19 pandemic effects;cue reactivity;Data;data acquisition;Data Analyses;data integration;data management;data sharing;data standards;design;Development;Distress;Dose;drinking;drinking onset;early onset;Economics;emerging adult;emerging adulthood;Emotional;Emotions;Ensure;Event;experience;externalizing behavior;Family;Female;follow-up;Frequencies;Functional Magnetic Resonance Imaging;Funding;Goals;hazardous drinking;Health;Heavy Drinking;high standard;imaging study;Independent Living;Individual;informatics infrastructure;information processing;Infrastructure;Life;Life Stress;Link;Machine Learning;machine learning framework;Magnetic Resonance Imaging;male;Measures;Mediating;Mission;Modeling;Monitor;multimodal neuroimaging;neurodevelopment;neuroimaging;neuropsychiatry;Neuropsychology;novel strategies;Outcome;Outcome Measure;pandemic disease;Participant;Patient Self-Report;Pattern;Personal Satisfaction;Persons;Phase;Physical activity;post-pandemic;pre-pandemic;predictive marker;preservation;Procedures;Process;prospective;Protocols documentation;Psychopathology;Psychosocial Factor;Quality Control;Questionnaires;Recording of previous events;Recovery;recruit;Resources;response;Rest;Sampling;Security;Sex Differences;Sex Differentiation;Site;Sleep;social;Standardization;Stress;Structure;Symptoms;System;Technology;Testing;underage drinking;Vertebral column;web app;young man;young woman;Youth

PROJECT_TITLE: NCANDA: Data Analysis Resource - Upgrading Computer System


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Clathrin-mediated endocytosis is responsible for uptake of molecules from the plasma membrane and surrounding environment, and therefore is crucial for determining how a cell will interact with its surroundings. Actin assembly near the plasma membrane generates forces that are harnessed for a variety of cellular processes including clathrin- mediated endocytosis. Mechanistic understanding of clathrin-mediated endocytosis and actin assembly are crucial to understanding normal cell physiology and a variety of pathological conditions.

PI_NAMEs: DRUBIN, DAVID G (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Actins;Address;Adhesions;Affect;Biochemical;Biochemical Reaction;Cell Line;Cell membrane;cell motility;Cell Physiology;Cell Polarity;cell type;Cells;Chimeric Proteins;Clathrin;Complement;COVID-19;Cytoskeletal Proteins;Cytoskeleton;Development Polarity;empowerment;Endocytosis;Environment;Event;Evolution;Excision;fluorescence imaging;Generations;genome editing;Human;human stem cells;human tissue;improved;Label;Learning;Lipids;Measures;Mediating;Membrane;Membrane Proteins;Normal Cell;Organelles;pandemic disease;Pathologic;Pathway interactions;Permeability;Play;Process;Production;Proteins;reaction rate;recruit;Regulation;Role;Route;Saccharomycetales;Site;stem cells;Structure;System;tissue/cell culture;trafficking;uptake;Vesicle;Yeasts

PROJECT_TITLE: Nikon confocal system for improved spatio-dynamic analysis of endocytic trafficking events

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


PHR: Project Narrative The mitotic spindle mediates the faithful segregation of DNA to daughter cells. Defects in this process can lead to birth effects and are implicated in cancer. Proposed studies aim to establish how the dynamic properties of the mitotic spindle are controlled and who chromosomes interact with the spindle to insure their faithful inheritance.

PI_NAMEs: BARNES, GEORJANA  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Anaphase;Behavior;Binding;Biochemical;Biological Assay;Birth;cancer prevention;Cell Cycle;Cell Cycle Stage;Cell Nucleus;Cells;chromosome replication;Chromosomes;Complex;Congenital Abnormality;Coupling;Cytoplasm;Cytoskeleton;daughter cell;Defect;Detection;Devices;DNA;Fluorescence Microscopy;Genetic;genome integrity;improved;in vivo;Kinesin;Kinetochores;Laboratories;Lateral;Malignant Neoplasms;Mediating;Microtubules;Mitosis;Mitotic;Mitotic spindle;Molecular Machines;Morphologic artifacts;mutant;Plus End of the Microtubule;preservation;Process;Property;protein complex;Protein Dynamics;Protein Kinase;Proteins;Regulation;Saccharomycetales;segregation;Source;Structure;System;Time;transmission process;Tubulin

PROJECT_TITLE: Nikon transmitted detection add-ons and piezo drive for improved in vivo mitotic spindle dynamics analysis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Contraception/Reproduction;Prevention

ORG_CITY: PHOENIX

ORG_STATE: AZ

PROJECT_TERMS: Applications Grants;Area;Biological;Contraceptive Agents;Contraceptive methods;Contractor;Contracts;experience;Funding;Grant;Intellectual Property;Methods;National Institute of Child Health and Human Development;Pharmacologic Substance;programs;Research;Research Activity;Services;small molecule

PROJECT_TITLE: INTELLECTUAL PROPERTY CONSULTING QUOTE FOR SERVICES FOR CONTRACEPTION RESEARCH


NIH_SPENDING_CATS: Clinical Research;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: SILVER SPRING

ORG_NAME: SOCIAL AND SCIENTIFIC SYSTEMS,  INC.

ORG_STATE: MD

PI_NAMEs: MATTHEWS, EMILIA  (contact)

PROJECT_TERMS: abstracting;Address;Area;Authorization documentation;Autoimmunity;Biological;Biological Specimen database;Case Report Form;Chemicals;Clinical;Clinical Data;clinical diagnostics;Clinical Management;Clinical Protocols;Clinical Research;Clinical Trials Database;Code;Collaborations;Collection;Complex;Computer Assisted;computer program;Computer Systems;computerized;Computers;Confidentiality of Patient Information;Contractor;Contracts;Copying Processes;Data;Data Analytics;Data Collection;data communication;Data Element;data management;data quality;Data Reporting;Database Management Systems;database query;database structure;Databases;Death Certificates;design;Development;Documentation;Electronic Mail;Electronics;Eligibility Determination;Employment;Ensure;Environmental Exposure;Equipment and supply inventories;Evaluation;Evaluation Studies;flexibility;Guidelines;Human;Human Resources;human subject protection;improved;Incentives;Information Systems;Instruction;Interview;Laboratories;Legal;Licensing;Maintenance;Manuals;Measurement;Measures;Medical Records;member;Methods;Microfilm;Modification;Monitor;multidisciplinary;Myositis;National Institute of Environmental Health Sciences;Occupational;Online Systems;Paper;Participant;Patients;Persons;Procedures;Process;programs;protocol development;Protocols documentation;quality assurance;Quality Control;Questionnaires;Records;recruit;Regulation;Reporting;repository;Research Project Grants;Resolution;response;Running;Sampling;Serious Adverse Event;service providers;Services;Specific qualifier value;Specimen;Standardization;Statistical Data Interpretation;Study Subject;symposium;System;Techniques;Technology;Telephone;Telephone Interviews;Terminology;Testing;Training;Twin Multiple Birth;United States National Institutes of Health;Update;usability;Validation;Work;Writing

PROJECT_TITLE: TASK ORDER 2R - DATA MANAGEMENT AND ANALYTICAL SUPPORT


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PI_NAMEs: MORSE, GENE  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Biological Assay;Certification;Clinical;Clinical Management;Clinical Pharmacology;Clinical Research;clinical research site;Clinical Trials;Communicable Diseases;Data;Data Management Resources;Development;Enrollment;Ensure;Future;HIV;improved;International;Laboratories;Measurement;Methods;Monitor;National Institute of Allergy and Infectious Disease;Performance;pharmacologic;Pharmacology;Pharmacology Study;Prevention Measures;programs;Publishing;quality assurance;Quality Control;Reagent;Sampling;Specific qualifier value;Standardization;Testing;Therapeutic;Training;Validation

PROJECT_TITLE: Clinical Pharmacology Quality Assurance (CPQA)


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: The goal of the Durham Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT) is to enhance the Veterans Health Administration's (VHA) ability to continually improve health care and optimize Veteran wellbeing and independence. ADAPT will lead innovative research on promoting and sustaining healthy lifestyles, improving access through virtual care, and optimizing Veteran function and independence. Working closely with VA and non-VA partners, ADAPT investigators will apply and advance state-of-the-art methods, translate research findings into meaningful practice change, and train the next generation of VA researchers. ADAPT will play a vital role in helping VHA meet the challenges of providing timely, coordinated, consistently high-quality care to more than 9 million Veterans each year.

PI_NAMEs: HASTINGS, SUSAN NICOLE (contact)

PROJECT_TERMS: Acceleration;Address;Area;Behavior;burden of illness;care systems;career development;Caring;Clinical;clinical care;Collaborations;Communities;Data Sources;design;Development;Educational workshop;effectiveness evaluation;Effectiveness of Interventions;Ensure;experience;Face;Family;Fostering;Funding;Goals;Grant;Health behavior;health care availability;health care service organization;Health Services;Health Services Research;Health system;Healthcare;Healthcare Systems;healthy lifestyle;implementation research;Improve Access;improved;Individual;innovation;Lead;Leadership;Life;Long-Term Care;Mentorship;Methods;Modeling;Names;next generation;novel;Observational Study;Personal Satisfaction;Phase;Physicians;Pilot Projects;Play;Policies;Postdoctoral Fellow;Pragmatic clinical trial;Process;Quality of Care;Recording of previous events;Research;research and development;Research Infrastructure;Research Personnel;research study;resilience;Resources;Role;routine practice;Science;social factors;Time;Training;Translating;Translations;Veterans;Veterans Health Administration;virtual healthcare;Work;World Health Organization

STUDY_SECTION_NAME: HCN1 COIN REVIEW[HCN1]


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The specific types and amounts of metabolite molecules present in biological systems, such as blood, serum, and tissues, provide critical information about health and disease. Metabolomics is a top-down approach, which involves identification and quantitation of metabolites in complex biological mixtures. The proposed research program aims at developing new metabolomics technologies, which are based on nuclear magnetic resonance (NMR) spectroscopy as well as in combination with cheminformatics and with mass spectrometry, to analyze a wide range of biological mixtures more comprehensively, accurately, and efficiently and to apply these tools and make them available to the scientific community, including via public web servers and databases, with synergistic benefits also for protein science.

PI_NAMEs: BRUSCHWEILER, RAFAEL  (contact)

PROJECT_TERMS: Address;Award;Biological;biological systems;Blood;Chemicals;cheminformatics;Communities;Complex;Databases;Diagnosis;Disease;Health;Human;Hybrids;Malignant Neoplasms;Mass Spectrum Analysis;metabolomics;Methodology;Methods;NMR Spectroscopy;novel strategies;Nuclear Magnetic Resonance;Nuclear Protein;Parents;programs;Proteins;Research;Science;Serum;spectroscopic data;synergism;Technology;Tissues;tool;United States National Institutes of Health;Urine;user-friendly;web server

PROJECT_TITLE: Advanced NMR, computational, and hybrid methods for metabolomics


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Dissemination and Implementation Research;Mental Health;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: MBARARA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY

PHR: Narrative Non-Communicable Diseases are an emerging global pandemic with disproportionately higher rates in developing countries. Uganda with a large rural based population, requires development and implementation of evidence-based interventions to address real-life problems and provide sustainable solutions. The proposed Building capacity for Implementation Science research in Non-Communicable Diseases (BImS-NCDs)” training hub at MUST, will provide leadership, best practices, research support, mentoring and training in epidemiological, prevention, and implementation science approaches in NCDs across the lifespan to the partner institutions in rural Uganda.

PI_NAMEs: OBUA, CELESTINO  (contact);WAKIDA, EDITH

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;Africa;Alcohol consumption;alcohol use disorder;Area;Behavioral;Brain;California;Cause of Death;Community of Practice;Developing Countries;Disease;Doctor of Philosophy;Epidemiology;Faculty;Funding;Future;General Hospitals;Grant;Health;Health Occupations;Health Professional;HIV;Human;implementation science;Infrastructure;Institution;Investments;Knowledge;Leadership;Life;life span;Massachusetts;Medicine;Mental disorders;Mental Health;Mentors;Mentorship;Methods;Mission;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National Institute on Alcohol Abuse and Alcoholism;Nervous System;Nervous System Disorder;pandemic disease;Personal Satisfaction;Persons;Prevention;Public Health;Research;Research Support;Research Training;Rural;Science;skills;Technology;theories;tool;Training;Uganda;United States National Institutes of Health;Universities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(55)R]


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SALSBURY COVE

ORG_NAME: MOUNT DESERT ISLAND BIOLOGICAL LAB

ORG_STATE: ME

PHR: Project Narrative Cellular pluripotency in the germline is maintained through processes within cytoplasmic assemblies called germ granules. The parent grant seeks to understand the function of individual germ-granule proteins, the purpose and conditions of their assembly, and their capacity for cellular reprogramming. This administrative supplement replaces an aging ultralow temperature freezer that is used to house the live strains and reagents needed for the studies outlined in the parent grant.

PI_NAMEs: UPDIKE, DUSTIN LYNN (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: 15 year old;3' Untranslated Regions;Administrative Supplement;Aging;Binding;Caenorhabditis elegans;Cell Nucleus;Cell Reprogramming;Cells;Chromatin;cold temperature;Complex;Cytoplasm;Cytoplasmic Granules;drug discovery;energy efficiency;Ensure;Event;experimental study;follow-up;Gene Expression;Germ;Germ Cells;Germ Lines;Glycine;healing;Human;in vivo;Individual;Inherited;Libraries;Life;Maintenance;Malignant Neoplasms;Modeling;Modernization;Mutation;Names;Nematoda;novel;Nuclear;Nucleic Acids;parent grant;pluripotency;preservation;Process;Proliferating;Proteins;Reagent;Regenerative capacity;Research;Resource Sharing;RNA;RNA Interference;Sampling;somatic cell nuclear transfer;Sterility;Therapeutic;Visualization;wound

PROJECT_TITLE: The function of germ granule processes that maintain pluripotency in the C. elegans germline


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE  Youth from low socioeconomic groups are at a systematic disadvantage in the provision of diabetes care, particularly diabetes technology which is associated with improvement in diabetes-specific outcomes. Thus, we urgently need studies to understand and ameliorate the persistent worsening of disparities of diabetes management and outcomes in youth from low socioeconomic backgrounds. This proposed research will (1) improve representation of diverse youth in the literature, (2) address the gap in knowledge of barriers and promoters in publicly insured youth, and (3) identify and address factors of worsening disparity in diabetes technology.

PI_NAMEs: ADDALA, ANANTA  (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: acceptability and feasibility;Address;Attitude;Award;behavioral health;brief intervention;career;Caring;Childhood;Childhood diabetes;Clinical;Clinical Trials;Communities;Continuous Glucose Monitor;Data;Databases;design;Development;diabetes management;Diabetes Mellitus;Disadvantaged;Disparity;disparity reduction;efficacy evaluation;Endocrinology;Epidemiology;Equity;ethnic minority population;Etiology;evidence base;Family;Focus Groups;Future;Goals;health disparity;implicit bias;improved;improved outcome;Inequity;innovation;Insulin-Dependent Diabetes Mellitus;interest;Intervention;intervention delivery;Knowledge;Literature;low socioeconomic status;Mentors;Mentorship;Methods;Modeling;multidisciplinary;Outcome;perceived discrimination;Phase;Physicians;practical application;promoter;Provider;provider factors;provider-level barriers;Proxy;public health insurance;Qualifying;Quality of life;racial minority population;Recommendation;Reporting;Research;Research Design;Research Methodology;Research Personnel;Scientist;skills;social;Socioeconomic Status;socioeconomics;statistics;Structure;Surveys;system-level barriers;Technology;technology intervention;Testing;therapy design;therapy development;Time;Training;Treatment Efficacy;Underrepresented Minority;Underrepresented Populations;United States;uptake;Youth

PROJECT_TITLE: Reducing Disparities in Pediatric Diabetes: Building the Evidence Base to Inform Effective Diabetes Technology Interventions in Underrepresented Minorities

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK(M1)-1-B]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Narrative. 15-Prostaglandin dehydrogenase (15-PGDH) degrades prostaglandin E2 (PGE2), a signaling molecule that promotes tissue repair and regeneration in multiple tissues. Therefore, inhibitors of 15-PGDH elevate PGE2 levels in tissue and may represent therapeutics for diseases characterized by ulceration or tissue damage. Here, we will use structure-based methods to design inhibitors of 15-prostaglandin dehydrogenase, determine the cell types that express and respond to 15-PGDH, and decipher the cytokine network that regulates tissue repair in response to PGE2.

PI_NAMEs: MARKOWITZ, SANFORD D.;PIEPER, ANDREW A;READY, JOSEPH M (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Acceleration;Adult;Alleles;analog;Backcrossings;Binding;Biochemistry;Biological Availability;Biotechnology;Biotinylation;Bleomycin;Bone Marrow;Bone Marrow Transplantation;Brain;Cell Fraction;cell type;Cells;Chemicals;cognitive function;Collaborations;Collection;Colon;Complex;conditional knockout;Cryoelectron Microscopy;cytokine;Cytokine Network Pathway;Cytokine Signaling;Data;Data Set;defined contribution;design;dextran sulfate sodium induced colitis;Dinoprostone;Disease;disease model;Drug Targeting;Engineering;Enzymes;Exclusion;Foundations;Future;Growth;Hematopoietic;Hippocampus;improved;in silico;in vivo;Individual;Inflammation;inhibitor;Injury;Joints;Kidney Diseases;Knock-out;knockout gene;Knockout Mice;Lead;Legal patent;Liver;LoxP-flanked allele;Macrophage;Maps;Mediating;Methods;Microglia;Modeling;molecular dynamics;mouse model;Mouse Strains;mRNA Expression;Mus;Neurons;Neurosciences;Oral;Organ;Oxidoreductase;Partial Hepatectomy;Pattern;Penetration;Peripheral;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;preservation;prevent;programs;Prostaglandins;protein expression;Proteins;Publications;Pulmonary Fibrosis;Recovery;Reporting;Research;Resolution;response;Rodent;Role;scaffold;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;small molecule;small molecule inhibitor;Specificity;Spleen;Stromal Cell-Derived Factor 1;structural biology;Structure;Techniques;Technology;Testing;Therapeutic;therapeutic target;three dimensional structure;Tissue Model;tissue regeneration;tissue repair;Tissues;Trauma;Traumatic Brain Injury;Ulcer;Ulcerative Colitis;Visualization

PROJECT_TITLE: Chemical, Structural and Cell-Signaling Interrogation of 15-Prostanglandin Dehydrogenase in Tissue Repair and Regeneration


ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE The sphingolipid metabolites, sphingosine-1-phosphate (S1P) and its precursors sphingosine and ceramides, have emerged as pleiotropic signaling molecules that regulate diverse cellular responses. This proposal on the elucidation of novel roles of sphingolipid metabolites in regulation of membrane contact sites, the areas where membranes from two organelles are found in close apposition, will lead to better understanding of how cellular organelles communicate and integrate their activities.

PI_NAMEs: SPIEGEL, SARAH  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Address;Area;Auditory;Bioenergetics;Biological Process;blood glucose regulation;Cell membrane;Cells;Ceramides;Cholesterol;Cholesterol Homeostasis;Coin;Communication;Enzymes;Family;Goals;Homologous Gene;human disease;Immune System Diseases;infancy;Inflammatory;Link;Location;Lower Organism;Lysosomes;Membrane;Metabolic;Metabolism;Mitochondria;mitochondrial membrane;Movement;Names;Neoplasm Metastasis;novel;Organelles;Organism;Process;Proteins;receptor;Regulation;Research;response;Role;sensor;Signal Transduction;Signaling Molecule;Site;Sphingolipids;Sphingosine;sphingosine 1-phosphate;sphingosine kinase;Stimulus

PROJECT_TITLE: Ins and outs of the bioactive sphingolipid metabolite sphingosine-1-phosphate


ADMINISTERING_IC: MD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Despite Venezuelans being among the fastest-growing migrant groups in the US and Colombia, there is limited knowledge on the interplay between key strengths, behavioral health outcomes, and well-being among this population during resettlement and over time. The proposed study aims to identify and compare key elements vis-à-vis thriving, flourishing, and behavioral health of Venezuelan crisis migrants in the US to those who relocated in Colombia. Findings from this diversity supplement will inform evidence-based policy efforts as well as the development of innovative and culturally relevant responses to future crisis migrations and the promotion of crisis migrants’ well-being.

PI_NAMEs: MALDONADO-MOLINA, MILDRED M (contact);SALAS-WRIGHT, CHRISTOPHER PATRICK;SCHWARTZ, SETH J.

PROGRAM_OFFICER_NAME: GARRIDO, CARLOS OSWALDO

PROJECT_TERMS: Acceleration;Address;Adult;behavior influence;behavioral health;career development;clinical practice;Clinical Research;Collaborations;Colombia;Colombian;Communities;community advisory board;Complex;Conflict (Psychology);Country;Data;Data Analyses;Data Collection;design;Destinations;Development;Elements;Epidemiology;evidence base;Exclusion;experience;Face;Fogarty International Center;Funding;Future;global health;Goals;Government;Health Disparities Research;Home;Hospitals;Human;Hurricane;Immigrant;improved;innovation;Intervention;Knowledge;Latin America;Latin American;Lead;Life;Memory;Mental Health;Mentors;Mentorship;Methods;Migrant;migration;National Institute on Minority Health and Health Disparities;Outcome;participant retention;Personal Satisfaction;physical conditioning;Policies;Population;prospective;Prospective Studies;Public Health;Puerto Rican;Qualitative Research;Research;research data dissemination;Research Methodology;Research Personnel;Research Project Grants;resilience;response;Risk;Risk Factors;Role;Science;Services;Stress;stressor;Surveys;Survivors;theories;Time;Training;Trauma;trauma exposure;United Nations;United States;United States National Institutes of Health;Venezuelan;Work

PROJECT_TITLE: Longitudinal Determinants of Thriving and Well-Being in Venezuelan Crisis Migrants


ED_INST_TYPE: OVERALL MEDICAL

ORG_CITY: HOUSTON

ORG_DEPT: OTHER BASIC SCIENCES

PHR: PROJECT NARRATIVE The proposed research program is relevant to public health because it encompasses the development and characterization of the highly specific monoclonal antibody inhibitors for disease-related proteases. These proteases are pivotal in the pathogenesis of many disorders including cancer, neuropathic pain, obesity, stroke, and viral infections. Highly specific monoclonal antibody inhibitors will accelerate research directed to a better understanding of basic pathology of these diseases and lead to the development of therapeutic interventions targeting these diseases.

PI_NAMEs: GE, XIN  (contact)

PROJECT_TERMS: Acceleration;Achievement;Antibodies;Antibody Binding Sites;antibody inhibitor;antibody libraries;Antibody-Dependent Enhancement;Binding;blood-brain barrier crossing;Cancer Model;Development;Disease;drug discovery;Drug Kinetics;Drug Targeting;Engineering;Enzyme Inhibition;Epitopes;Family;Generations;Half-Life;Health;high throughput screening;Human;Hybridomas;inhibiting antibody;inhibitor therapy;invention;Laboratories;Malignant Neoplasms;Membrane;Methodology;Methods;Monoclonal Antibodies;mouse model;new technology;Obesity;painful neuropathy;Pathogenesis;Pathology;Peptide Hydrolases;Pharmacologic Substance;Physiological Processes;Prodrugs;programs;Property;Protease Inhibitor;Public Health;rational design;Research;SARS-CoV-2 inhibitor;screening;Series;Serine Protease;Serum;Signaling Molecule;small molecule inhibitor;Specificity;Stroke;success;Technology;Therapeutic;therapeutic development;Therapeutic Intervention;Therapeutic Monoclonal Antibodies;TMPRSS2 gene;Treatment Efficacy;Virus Diseases

PROJECT_TITLE: Therapeutic Monoclonal Antibodies Inhibiting Proteases of Biomedical Importance