NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Lipids play an important role as signaling molecules to increase insulin secretion. However, the unregulated accumulation of lipids damages beta cells resulting in type 2 diabetes. By examining how intracellular trafficking of lipids are regulated at an intracellular organelle called lipid droplets, we aim to identify a way to achieve effective usage of lipids in beta cells, while preventing accumulation of toxic lipids that lead to type 2 diabetes.

PI_NAMEs: IMAI, YUMI  (contact)

PROJECT_TERMS: Acceleration;Acid Lipase;Acidity;Acute;Address;Adipocytes;Adipose tissue;Adult;Affect;Beta Cell;Catabolism;Cell model;Cell Physiology;Cells;Characteristics;Chronic;Data;Development;Diabetes Mellitus;Digestion;Emotional;Enterocytes;Exposure to;Failure;Fatty Acids;Fatty Liver;Functional disorder;Glucose;Health;Hepatocyte;Homeostasis;Human;immunodeficiency;Impairment;In Vitro;in vitro testing;in vivo;in vivo Model;Insulin;insulin secretion;islet;Learning;Lipase;lipid metabolism;Lipid Mobilization;lipid transport;Lipids;Lipolysis;Liver;Lysosomes;Maintenance;Mediating;Metabolism;Mitochondria;Mus;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrient deprivation;Nutritional;Obesity;Organelles;Overnutrition;Pathway interactions;perilipin;Physiological;Play;prevent;Process;Proteins;Rattus;Regulation;Reporting;Research;response;Role;Signaling Molecule;Stress;Testing;Time;Transplantation;western diet;Work

PROJECT_TITLE: Role of lipid droplet proteins in islet function in diabetes and obesity


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative The primary objective of this proposal is to assess the anti-cancer efficacy of the selective glucosylceramide synthase inhibitor, eliglustat, alone and in combination with anti-PD-L1 in preclinical mouse models of triple- negative breast cancer, and to define the mechanism(s) by which eliglustat induces anti-cancer immune response. Success of this proposal will establish utility for eliglustat and other inhibitors of glucosylceramide synthase as novel ‘immunometabolic adjuvants’ for the treatment of TNBC, thus creating a new paradigm for cancer immunotherapy. Given that eliglustat is already FDA-approved for Gaucher disease with established toxicity profiles, it has high potential to readily be directly translated into clinical use.

PI_NAMEs: FAHRMANN, JOHANNES F (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: 4T1;Adjuvant Therapy;Alternative Therapies;anti-cancer;anti-PD-L1;anti-tumor immune response;Binding;Biochemical;Biological Assay;Blood Chemical Analysis;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;cancer cell;cancer immunotherapy;CD8-Positive T-Lymphocytes;Cell Death;Cells;Cellular Assay;Ceramide glucosyltransferase;Ceramides;Chemicals;chemokine;chemotherapy;Clinical;Coupled;cytokine;Cytotoxic T-Lymphocytes;Dose;early phase clinical trial;Enzymes;Evaluation;Expression Profiling;extracellular vesicles;Family;FDA approved;Gaucher Disease;glycation;Glycosphingolipids;Histologic;histopathological examination;Immune;Immune response;Immunocompetent;Immunofluorescence Immunologic;Immunohistochemistry;Immunophenotyping;Immunoprecipitation;Immunotherapy;improved;in vivo;Infiltration;inhibitor;interest;Interferons;Intervention;lipidomics;Lipids;Malignant Breast Neoplasm;mammary;mass spectrometric imaging;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Methods;MHC Class I Genes;Mitochondria;Mouse Mammary Tumor Virus;mouse model;Mus;Neoplasm Metastasis;novel;novel therapeutic intervention;Pathologic;Pathway interactions;patient derived xenograft model;Patients;Peptides;Pharmacotherapy;Phenotype;Plasma;pre-clinical;primary endpoint;Prognosis;programs;Proteomics;Recurrence;Resistance;response;Role;Signaling Protein;small molecule;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Sphingomyelins;Stimulator of Interferon Genes;success;Surface;T cell response;T-Cell Activation;T-Lymphocyte Epitopes;tandem mass spectrometry;Technology;Testing;Tissues;Toxic effect;TP53 gene;transcriptome sequencing;transcriptomics;Translating;Treatment-related toxicity;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor-Derived;Western Blotting

PROJECT_TITLE: Repurposing Glucosylceramide Synthase to Promote Mitochondrial Lethality and Potentiate an Anti-Tumor Immune Response in Triple-Negative Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative/Public Health Relevance With greater access to effective treatment, adults with HIV around the world are living to older ages. However, we have little knowledge about aging-related conditions, such as frailty and disability, or their causes in older adults with HIV in low- and middle-income countries where the HIV epidemic is greatest. Understanding how local socioeconomic factors, chronic coinfections, and comorbidities contribute to aging-related diseases and outcomes in older adults with HIV is critically important as life expectancies improve worldwide.

PI_NAMEs: CASTILHO, JESSICA L (contact);GRINSZTEJN, BEATRIZ

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Adult;Affect;Age;Age Years;Aging;aging mechanism;aging morbidity;aging related;aging related disease;antiretroviral therapy;Area;Assessment tool;Atherosclerosis;Automobile Driving;behavioral economics;Biological;Biology of Aging;Brazil;Canada;Cardiometabolic Disease;Caribbean region;Caring;Central America;Cessation of life;Chagas Disease;chemokine;Chronic;chronic infection;Cities;Clinical;Clinical assessments;clinical predictors;Clinical Research;co-infection;Collaborations;comorbidity;Country;cytokine;Cytomegalovirus;Data;Development;disability;Disease;early onset;effective therapy;Elderly;Epidemic;epidemiologic data;Epidemiology;epidemiology study;Evaluation;experience;falls;frailty;functional decline;Geriatric Assessment;Geriatrics;Germany;Health Policy;HIV;HIV Infections;Hospitalization;Human Herpesvirus 8;human old age (65+);Human T-lymphotropic virus 1;Immunologics;Immunology;Impaired cognition;improved;Income;Individual;Induction of Apoptosis;Infection;infection burden;Inflammation;Inflammatory;inflammatory marker;insight;Institution;Knowledge;Laboratories;Latin America;Life Expectancy;Ligands;Link;Long-Term Effects;Longitudinal Studies;low and middle-income countries;Lymphocyte;Macrophage;Measures;Mediating;Medical Economics;mitochondrial dysfunction;modifiable risk;Morbidity - disease rate;mycobacterial;Neurocognitive Deficit;novel;Observation in research;older adult;Older Population;Onset of illness;Outcome;pathogen;Pathogenesis;Pathway interactions;Persons;Positioning Attribute;Productivity;prospective;Protein Isoforms;public health relevance;Quality of life;Recording of previous events;recruit;Research;Research Personnel;Resources;Risk Factors;risk prediction;risk stratification;Screening procedure;senescence;social health determinants;Socioeconomic Factors;socioeconomics;Source;South America;Standardization;syndemic;Syndrome;Telomere Shortening;TNF gene;Toxoplasmosis;Translational Research;translational study;Trypanosoma cruzi;Tuberculosis;United States;United States National Institutes of Health;Validation;Viral

PROJECT_TITLE: Longitudinal Study of HIV and Aging in Brazil

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Immunotherapy;Nutrition;Obesity;Women's Health Research

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative Although obesity has previously been established as a significant risk factor in the development of several cancer types (including breast cancer) and resistance to immunotherapy, there is a lack of genetic evidence for directly attributing obesity to the initiation or progression of its associated breast cancer. Noncoding RNAs have recently emerged as key players in a multitude of cellular signaling processes, and preliminary data has suggested that the upregulation of the small nucleolar RNA (snoRNA) SNORD46 is correlated with both increases in body mass index (BMI) and diminished infiltration of cytotoxic leukocytes. Therefore, this proposal will dissect the molecular mechanisms of adipocyte-expressed SNORD46 under obese conditions, implicate SNORD46-leukocyte interactions in driving obesity-associated immune resistance, and assess the efficacy of a SNORD46 LNAs targeted therapy in improving CD8+ T-cell infiltration and sensitizing obesity-associated breast tumors to immunotherapy.

PI_NAMEs: LIN, CHUNRU  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Adipocytes;Adipose tissue;Antisense Oligonucleotides;Attenuated;Automobile Driving;Binding;Biological;Blood;Body mass index;bone;Breast Cancer Patient;breast cancer progression;cancer initiation;cancer type;CD8-Positive T-Lymphocytes;CD8B1 gene;Chromatin;Clinical;computational pipelines;cytotoxic;Data;Development;diet-induced obesity;Down-Regulation;Drug Kinetics;effectiveness evaluation;efficacy evaluation;Energy Metabolism;Essential Genes;Event;Exhibits;Foundations;Gene Targeting;Genes;Genetic;Genetic Transcription;genetic variant;glucose metabolism;Goals;Heterozygote;High Fat Diet;immune checkpoint blockers;immune resistance;Immunotherapeutic agent;Immunotherapy;Impairment;improved;in vivo;infiltrating duct carcinoma;Infiltration;Interleukin-15;interleukin-15 receptor;knock-down;Knock-in;Knock-in Mouse;Knowledge;Leukocytes;lipid biosynthesis;Lipolysis;locked nucleic acid;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;Mammary Neoplasms;Mechanics;Mediating;Molecular;Monoacylglycerol Lipases;Mouse Mammary Tumor Virus;Mouse Strains;Mus;Natural Killer Cell toxicity;Natural Killer Cells;next generation;Normal tissue morphology;Obese Mice;obese patients;Obesity;Outcome;Pathway interactions;PD-1/PD-L1;PD-L1 blockade;Phosphorylation;Process;Proliferating;Protein Tyrosine Kinase;Resistance;Risk Factors;Role;Sampling;Serum;Signal Pathway;Signal Transduction;Small Nucleolar RNA;Stat5 protein;survival outcome;T cell infiltration;targeted treatment;Therapeutic;therapeutic target;Toxic effect;treatment strategy;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumorigenesis;Underweight;Untranslated RNA;Up-Regulation;Variant

PROJECT_TITLE: Targeting Small Nucleolar RNA Augments Immunotherapeutic Efficacy

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The proposed project aims to develop innovative digital media messages (e.g., photos, videos, pictures with text, text-only content) targeting alcohol-involved bystander intervention, or how alcohol use functions to inhibit bystander intervention for sexual violence. A pilot study will be conducted to assess the feasibility, acceptability, and preliminary efficacy of digital media messages in a social media intervention among high- risk college students who engage in heavy episodic drinking. This R21 has great potential to inform a scalable social media intervention targeting alcohol-involved bystander intervention, particularly among college students who engage in high-risk drinking.

PI_NAMEs: SCHIPANI-MCLAUGHLIN, ANNE MARIE  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Adult;Affect;aged;Alcohol consumption;alcohol effect;alcohol intervention;alcohol involvement;alcohol myopia;Alcohols;Area;Attention;Attitude;Awareness;Behavior;behavior change;Behavior Therapy;behavioral response;Belief;binge drinking;Cellular Phone;college;Cues;Data;Development;digital;digital delivery;digital media;drinking;Educational process of instructing;efficacy evaluation;Epidemic;Focus Groups;follow-up;Future;Health behavior;high risk;high risk drinking;Hour;Image;Impaired cognition;improved;Individual;innovation;Instagram;Intervention;intervention refinement;Intoxication;Knowledge;Lead;Liquid substance;Manuals;Media Campaign;Media Intervention;men;National Institute on Alcohol Abuse and Alcoholism;Neurobiology;Online Systems;Participant;Patient Self-Report;Pilot Projects;Placebos;Positioning Attribute;Predisposition;Prevention program;primary outcome;Principal Investigator;Procedures;programs;Protocols documentation;Public Health;Published Comment;Randomized;randomized, clinical trials;recruit;Research;Resistance;Resources;Risk;Sampling;Scanning;secondary outcome;sexual assault;sexual violence;Sexual violence prevention;skills;social media;Strategic Planning;student participation;Surveys;Technology;Testing;Text;theories;university student;Violence;violence victimization;visual tracking;Woman

PROJECT_TITLE: Digital Media Messages Targeting Alcohol-involved Bystander Intervention: A Pilot Study

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Cancer;Liver Disease;Rare Diseases;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: HCC is a highly aggressive cancer whose incidence is on the rise, made of cells resembling hepatocytes, resulting from chronic Hepatitis B/C Virus infection, non-alcoholic steatohepatitis (NASH), and Alcoholic Liver Disease (ALD). Based on our preliminary data in experimental models, metabolic injury accelerates progression of HCC by upregulation of interleukin 17A (IL-17A). Current study will investigate the role of IL-17 signaling in the pathogenesis of ALD-and NASH-induced HCC using mouse models and patient material, and will provide new insights into therapeutic targeting of IL-17 signaling for treatment of HCC patients with ALD and NASH.

PI_NAMEs: BRENNER, DAVID A.;KISSELEVA, TATIANA  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Ablation;Acceleration;Acetylgalactosamine;Address;AFP gene;Alcoholic Liver Diseases;Alcohols;Anti-sense RNA;Archives;Attenuated;Body mass index;Caspase;CCL2 gene;Cells;chemokine;Cholesterol;Chronic Hepatitis B;Cirrhosis;Collaborations;Data;Development;Exocytosis;exosome;Experimental Models;Fatty Liver;Fibrosis;gain of function;Gene Expression;Genes;Genetic;genetic approach;Goals;Hepatic Stellate Cell;Hepatitis B Incidence;Hepatitis B Virus;Hepatitis C;Hepatitis C virus;Hepatitis Viruses;Hepatocyte;hepatocyte injury;Human;IL17 gene;IL17 Signaling Pathway;In Vitro;in vivo;Incidence;Inflammation;inhibitor;injured;Injury;insight;Interleukin-6;Interleukins;Knock-out;Knockout Mice;lipid biosynthesis;Liver;Liver Fibrosis;liver injury;loss of function;Macrophage;Malignant Neoplasms;Mediating;Mediator;Metabolic;mouse model;Mus;Mutagenesis;mutant;Myeloid Cells;nonalcoholic steatohepatitis;novel;novel therapeutics;Obesity Epidemic;Oligonucleotides;overexpression;Pathogenesis;Patients;Primary carcinoma of the liver cells;Production;Resected;response;Role;Side;Signal Pathway;Signal Transduction;Signaling Molecule;SP1 gene;STAT3 gene;Steatohepatitis;System;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Tissues;tool;transcriptome sequencing;Translating;Up-Regulation

PROJECT_TITLE: The role of IL-17 signaling in alcohol-induced HCC

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Restoration of adaptive immunity after radiation damage requires a functional thymus, the fundamental site of T cell generation. Although extremely sensitive to insult, the thymus contains a remarkable capacity for repair; however, thymic regenerative capacity diminishes as a consequence of age and after severe injury such as that caused by radiation injury, leading to a prolonged period of T cell depletion that can impact considerably on outcomes. In this proposal we seek to exploit the mechanisms that govern this regenerative response into rational strategies to boost immune function after radiation damage, even in recipients whose thymus has been impacted by age.

PI_NAMEs: DUDAKOV, JARROD  (contact)

PROGRAM_OFFICER_NAME: WINTERS, THOMAS A

PROJECT_TERMS: Acute;adaptive immunity;Age;age effect;aging population;Agonist;Apoptosis;BMP4;Cell Death;Cell Physiology;cell regeneration;Cells;Complex;conditioning;Data;Deterioration;Dose;Endothelial Cells;Equilibrium;experience;Functional disorder;G-Protein-Coupled Receptors;Generations;Goals;GPR39 gene;Hematopoietic Stem Cell Transplantation;Immune;immune function;Immune Targeting;Immunity;Immunocompetence;immunogenic cell death;Immunologics;improved;Infection;Injury;innovation;interleukin-22;interleukin-23;Ionizing radiation;Kinetics;Life;life span;Lymphoid Cell;Lymphopenia;Mediating;medical countermeasure;Molecular;Morbidity - disease rate;mortality;Mus;Natural regeneration;Outcome;Pathway interactions;Pattern;pharmacologic;Population Heterogeneity;preclinical study;Process;Production;programs;Purinoceptor;Radiation;Radiation Accidents;Radiation Dose Unit;Radiation induced damage;Radiation Injuries;receptor;Recovery;Recovery of Function;regenerative;Regenerative capacity;Regenerative pathway;Regenerative response;Rejuvenation;repaired;response;restoration;severe injury;sex;Signal Transduction;Site;Stress;T cell reconstitution;T-Cell Depletion;T-Cell Development;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Thymic epithelial cell;thymic regeneration;thymocyte;Thymus Gland;tissue regeneration;Tissues;Whole-Body Irradiation;Zinc

PROJECT_TITLE: Modulation of signaling from damage-associated molecular patterns to improve radiation-induced thymic dysfunction


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: FARMINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative The precise regulation of cartilage cells is critical for the normal development, morphology and elongation of the long bones. This new project will apply cutting-edge technologies to determine how changes in the expression, and enzymatic activity of an epigenetic factor called Dot1L can influence the growth of the long bones during development. Fundamental knowledge gleamed from our studies will provide new mechanistic insights into how skeletal growth defects arise, and may inform the development of Dot1L-targeted therapies.

PI_NAMEs: GUZZO, ROSARIA M. (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Address;adverse outcome;Biological Assay;Biology;bone;Bone Development;Bone Growth;Bone Morphogenetic Proteins;Cartilage;cartilage cell;Catalytic Domain;Cell Differentiation process;Cells;Chemicals;Child;ChIP-seq;Chondrocytes;Chondrogenesis;Chromatin;Chromatin Remodeling Factor;Complex;conditional knockout;CRISPR/Cas technology;Data;Defect;Development;Disease;Engineering;Enzymes;Epigenetic Process;epigenetic regulation;Epiphysial cartilage;experimental study;Female;Functional disorder;Future;Gatekeeping;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene network;Genes;Genetic Transcription;genome wide methylation;genome-wide analysis;Goals;Growth;Growth and Development function;Hindlimb;histone methyltransferase;histone modification;Histones;Hypertrophy;Impairment;In Vitro;in vivo;innovation;insight;Knock-out;Knowledge;Limb Bud;Limb structure;long bone;Lysine;male;Malignant Childhood Neoplasm;Mesenchyme;Methylation;methylation pattern;Methyltransferase;Molecular;Molecular Conformation;Morphology;Mus;mutant;Mutant Strains Mice;novel;Outcome Study;Pathologic;Pathway interactions;Pattern;pharmacologic;Phenotype;Physiologic Ossification;Physiological;Play;Post-Translational Protein Processing;premature;Process;programs;Proliferating;protein function;Proteins;Publishing;Regulation;Reporting;Research Personnel;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skeletal;Skeletal Development;small molecule;targeted treatment;Technology;telomere;Testing;Therapeutic;therapeutic target;transcriptome sequencing;transcriptomics

PROJECT_TITLE: The role of Dot1L activity in chondrogenic differentiation

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse;Women's Health Research

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Opioid overdose fatalities in women are outpacing that of men, and women with opioid use disorder have unique clinical presentations, barriers to treatment engagement, and treatment needs. Recently the US Department of Health and Human Services’ Office on Women’s Health outlined the importance of providing care to women with opioid use disorder that is gender-specific and emphasized that women-focused services are needed to increase the use of effective medication treatments. This proposal aims to develop and examine the feasibility of a gender-specific digital intervention for women with opioid use disorder in order to increase their initiation and engagement with evidence-based medication treatments.

PI_NAMEs: SUGARMAN, DAWN E (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Address;Affect;Applied Skills;Area;barrier to care;career;Caring;Child;Clinical;Continuity of Patient Care;Data;Data Analyses;design;Development;digital;digital health;digital intervention;digital platform;digital technology;Dissemination and Implementation;Dropout;effective intervention;efficacy trial;Etiology;evidence base;Evidence based treatment;Fatality rate;Feedback;follow-up;Functional impairment;Future;Gender;Goals;Health Personnel;Hospitals;improved outcome;Individual;innovation;Inpatients;Measures;Medical;medical schools;meetings;men;Mental disorders;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;mobile delivery;Modeling;Modification;mortality;Online Systems;opioid overdose;opioid use disorder;Outcome;overdose death;Participant;Persons;Pharmaceutical Preparations;Phase;physical conditioning;Positioning Attribute;post intervention;Process;programs;prototype;Randomized, Controlled Trials;Recovery;recruit;reduced substance use;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resources;satisfaction;Services;Severities;skill acquisition;skills;Statistical Methods;Substance Use Disorder;symposium;Testing;therapy development;Time;Training;Training Activity;trauma exposure;treatment as usual;Treatment outcome;United States Dept. of Health and Human Services;user centered design;Vulnerable Populations;Woman;Women's Health;Women's prevalence;women's treatment

PROJECT_TITLE: Increasing Women's Engagement in Medication Treatment for Opioid Use Disorder through Digital Intervention

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE  Endocytosis is a core process used by all eukaryote’s cells to take in nutrients and regulate communication at their surface. Defects in endocytosis are involved in a wide variety of diseases such as cancer, neuropathies and metabolic syndromes, and viruses can infect cells through CME. Understanding how the mechanical properties of the cell’s membrane and the protein machinery at the site of endocytosis will be key to develop new therapies for a broad range of diseases, for example by modulating endocytosis with drugs that control membrane tension rather than target specific proteins.

PI_NAMEs: BERRO, JULIEN  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Actins;Behavior;biophysical properties;Buffers;Cell membrane;Cell Physiology;cell type;Cells;chemical binding;Clathrin;coated pit;Communication;Complex;crosslink;Crosslinker;Cytoskeleton;Data;Defect;Dependence;Diameter;Disease;Drug Controls;Elasticity;Endocytic Vesicle;Endocytosis;Eukaryota;Eukaryotic Cell;FASTK Gene;Fimbrin;Fission Yeast;Funding;Geometry;In Vitro;in vivo;Individual;Kinetics;laser tweezer;Lipids;Malignant Neoplasms;Mammalian Cell;mathematical model;Measures;mechanical properties;Mediating;Membrane;Metabolic syndrome;Microfilaments;Modeling;Molecular;Myosin Type I;nanoscale;Neuropathy;novel therapeutics;Nutrient;optic tweezer;particle;pathogen;polymerization;Polymers;pressure;Process;Production;Property;protein crosslink;Proteins;Protoplasts;receptor;reconstitution;Recycling;Regulation;Reporting;residence;Shapes;simulation;single molecule;Site;Stress;Structure;Subcellular structure;Surface;Testing;Time;Vesicle;Virus;Yeasts

PROJECT_TITLE: Molecular mechanisms of force production and force sensing during clathrin-mediated endocytosis

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: AT

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Complementary and Integrative Health;Dietary Supplements;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Nutrition

ORG_CITY: NORMAN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: PROJECT NARRATIVE Prebiotics is a potential treatment for dysbiosis in human gut microbiota, which plays a role in many diseases, including diabetes and obesity. The proposed research is relevant to public health because we will develop and demonstrate the proteomic stable isotope probing approach for characterization of the metabolism of prebiotics by gut microorganisms.

PI_NAMEs: PAN, CHONGLE  (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Acceleration;Address;Algorithms;Animals;Bioinformatics;carbon fiber;Carbon Isotopes;Cloud Computing;Coculture Techniques;Communities;Complement;Complex;Complex Analysis;Computer Analysis;computerized data processing;cost;Data;data acquisition;Data Analyses;data standards;Databases;deep learning algorithm;Detection;Diabetes Mellitus;Diet;Dietary Fiber;Disease;dysbiosis;Environment;Equilibrium;experimental study;Genotype;Goals;gut bacteria;gut microbes;gut microbiome;gut microbiota;Health;hemicellulose;high throughput technology;Human;human microbiota;improved;In Situ;In Vitro;in vivo;innovation;Inulin;Knowledge;Label;large datasets;Link;Machine Learning;machine learning model;maltodextrin;Mass Spectrum Analysis;Measurement;Measures;Metabolic;metabolic abnormality assessment;Metabolism;Metagenomics;metaproteomics;metatranscriptomics;Methodology;Methods;Microbe;microbial;microbial community;microbiome;microbiota;microorganism;Modeling;Mus;novel;novel strategies;nutrition;Nutrition Disorders;Obesity;Organism;Outcome;parallel computer;Pathway interactions;Pattern;Peptides;Performance;Population;prebiotics;prevent;Probiotics;protein biomarkers;Protein Biosynthesis;Proteins;Proteomics;Public Health;Reproducibility;Research;Research Personnel;Resources;Ribosomal RNA;Role;Running;Shotguns;Specificity;stable isotope;Symbiosis;Techniques;Technology;Therapeutic;Time;tool;two-dimensional;Work

PROJECT_TITLE: Proteomic Stable Isotope Probing as a Novel Approach for Linking Prebiotics with Active Gut Microbiota

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Nutrition;Obesity

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE UCLA LIFT-UP (Leveraging Institutional support For Talented, Underrepresented Physicians and/or Scientists) proposes to develop a mentoring program that contributes to diversity among scientists pursuing research careers in nutrition, obesity, and diabetes. We will provide a teaching and mentorship curriculum that builds confidence and motivation among research fellows and junior faculty from underrepresented racial/ethnic groups, to help them successfully obtain research funding and progress to research independence.

PI_NAMEs: DURU, OBIDIUGWU KENRIK (contact);MANGIONE, CAROL M

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Address;Aging;Area;Award;base;Behavioral Research;Biomedical Research;California;Cardiology;career;Caring;Clinical;Clinical Sciences;Collaborations;Communication;Communities;design;Development;Diabetes Mellitus;Disease;Diverse Workforce;Educational Curriculum;Educational process of instructing;Endocrinology;Ethnic Population;Evaluation;experience;Faculty;faculty mentor;Fostering;Funding;Funding Opportunities;Goals;Health;health equity;Health Services;Health Services Research;Health system;improved;Institution;Insulin Resistance;Internal Medicine;Intervention;Laboratories;Leadership;Medicine;Mentors;Mentorship;Metabolism;Minority;Minority Health Research;minority investigator;Mission;Molecular;Motivation;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute on Aging;Natural experiment;nutrition;obese patients;Obesity;Outcome;Physicians;Physiological Processes;Policies;Policy Analysis;Postdoctoral Fellow;prevent;Prevention;Program Development;Program Evaluation;programs;Public Health Schools;Publications;racial population;Recording of previous events;recruit;Reduce health disparities;Research;research clinical testing;Research Infrastructure;Research Personnel;Research Support;Research Training;Science;Scientist;Site;skills;success;Talents;Teacher Professional Development;Translational Research;Translations;Underrepresented Populations;Vision;web site;Work


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stomach Cancer

PHR: NARRATIVE Pre-cancerous metaplasia develops from reprogramming of protein-secreting chief cells into protective mucous-secreting cells. We will study how innate lymphoid cells (ILC2s) and specific populations of fibroblasts (telocytes) promote both the development of metaplasia as well as progression of metaplasia towards dysplasia. These studies will elucidate elements of the pre-cancerous milieu that may be targets for development of strategies for gastric cancer prevention.

PI_NAMEs: CHOI, EUNYOUNG ;GOLDENRING, JAMES RICHARD (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Acute;Antral;Atrophic;base;Cancerous;Cell Lineage;Cell secretion;Cells;Chief Cell;Chronic;chronic infection;Coculture Techniques;Development;Dysplasia;Elements;Evolution;Fibroblasts;gastric cancer prevention;gastric corpus;Gastric mucosa;gastric organoids;Gastric Parietal Cells;Gland;Goblet Cells;Helicobacter pylori;Human;human disease;Immune;In Vitro;Inflammation;Inflammatory;Injury;Interleukin-13;Intestinal Metaplasia;Intestines;Investigation;Lesion;Lymphocyte;Lymphoid Cell;Maintenance;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Metaplasia;Metaplastic Cell;Mucous body substance;Mucous Membrane;Mus;Neoplasms;neoplastic;Patients;Physiological;Population;premalignant;Protein Secretion;repaired;response;Sensory;Smooth Pursuit;spasmolytic polypeptide;STAT6 gene;stem cell niche;Stomach;System;Tissues;Transcriptional Regulation;transdifferentiation

PROJECT_TITLE: Induction and Evolution of Metaplasia in the Stomach

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Pediatric;Substance Misuse

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE Effective strategies are needed that can secure and direct financial resources to support the adoption of evidence-based practices in adolescent substance use treatment services. The proposed research aims to compare two grant-making strategies used by the U.S. Substance Abuse and Mental Health Services Administration on the widespread adoption and sustained use of one such evidence-based practice, the Adolescent Community Reinforcement Approach, over the past 13+ years. Results will provide critically needed information about the effects of different grant-making strategies in supporting widespread and long- term availability of evidence-based practices, which is necessary to achieving large-scale reductions in adolescent substance use disorders and their major associated public health and societal impacts.

PI_NAMEs: DOPP, ALEX RICHARD (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Address;Administrator;Adolescent;adolescent substance use;Adoption;Award;behavioral health;Case Study;Certification;Client;Cohort Effect;Communities;community based treatment;comparative;Consultations;contextual factors;cost;Data;data integration;Development;Elements;Eligibility Determination;Evidence based practice;Experimental Designs;Exploration, Preparation, Implementation, and Sustainment;Focus Groups;Funding;Grant;Health;health economics;Health Services;implementation outcomes;implementation science;implementation strategy;Infrastructure;innovation;Interview;Investments;Knowledge;Leadership;Measures;Mediating;Mediation;Mediator;Methods;Modeling;National Institute of Drug Abuse;Natural experiment;novel;Outcome;Penetration;Perception;policy implication;Policy Maker;Politics;Psychological reinforcement;Public Health;Public Policy;Quasi-experiment;Research;Research Design;Resources;Sampling;Secure;statistics;Substance Abuse Treatment Centers;Substance Use Disorder;substance use treatment;success;Supervision;Surveys;System;Time;Training;treatment organization;treatment services;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;Variant;Work

PROJECT_TITLE: Comparing Two Federal Financing Strategies on Treatment Penetration and Sustainment

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE: The Breast Cancer Family Registry (BCFR) Cohort is an international cohort in the U.S., Canada and Australia comprised of multi-generational families (33,037 women and 6,992 men from 15,056 families) that started in 1995. We will strengthen and continue to provide to the research community an important and unique long-term family cohort with extensive epidemiologic and molecular data to address cutting-edge and clinically important research questions on breast cancer susceptibility, outcomes, survival and survivorship with the overall goal of advancing knowledge of the biology of breast cancer development and progression so as to reduce the cancer burden and cancer disparities.

PI_NAMEs: ANDRULIS, IRENE ;COLONNA, SARAH ;DALY, MARY BERYL;GENKINGER, JEANINE M.;HOPPER, JOHN L;JOHN, ESTHER M.;TERRY, MARY BETH  (contact)

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TERMS: Address;Adult women;Affect;Age;Age Years;Air Pollution;Asian;Australia;biobank;Biological Assay;Biology;Biopsy Specimen;Black race;Blood specimen;breast cancer diagnosis;breast cancer family;breast cancer family registry;Canada;Cancer Burden;Cancer Etiology;cancer health disparity;Cancer-Predisposing Gene;Cardiotoxicity;cell free DNA;Cell Line;Cell Separation;Cessation of life;Characteristics;Clinical;cohort;Collaborations;Collection;colon cancer family registry;Communities;Data;Data Collection;Data Element;data harmonization;Data Linkages;Data Pooling;Databases;Dedications;Detection;Development;Diagnosis;diagnostic value;Disease;Disease Progression;DNA;Electronic Health Record;Enrollment;Environmental Exposure;Epidemiology;Ethnic Origin;Event;Family;Family member;First Degree Relative;follow-up;Future;genetic epidemiology;Genetic Risk;Genomics;Goals;healthy aging;Hispanic;Incidence;Individual;Interdisciplinary Study;International;Investigation;Knowledge;Length;Life Cycle Stages;liquid biopsy;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;member;men;metabolomics;minimally invasive;Molecular;Molecular Epidemiology;Monitor;neoplasm registry;Newly Diagnosed;novel;novel marker;Outcome;Pacific Islander;Participant;Pathogenicity;Plasma;Plasma Cells;Population;Predisposition;prognostic;prospective;Proteomics;Protocols documentation;Public Health;Race;Recording of previous events;recruit;Recurrence;Registries;Relapse;Research;Research Personnel;Resources;Risk;risk prediction model;Role;Sampling;Site;socioeconomic diversity;Surveys;survivorship;Time;treatment and outcome;Tumor Burden;tumor DNA;Tumor Tissue;Underrepresented Populations;Update;Urine;validation studies;Variant;Woman;young woman

PROJECT_TITLE: Breast Cancer Family Registry


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STANFORD

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative  The proposed studies seek an integrated, systems level understanding of how multiple molecular mechanisms collaborate to control the critical biological switch from proliferation to differentiation, a key regulatory point in the adult stem cell lineages that underlie tissue maintenance and repair. Failure to cleanly execute this switch may contribute to genesis of cancer. Our results will reveal how cell type and stage specific alternative mRNA processing, translational control, changes in chromatin architecture, cell type specific transcriptional regulators, and cell-cell communication act together to ensure that proliferation of precursor cells ceases and the correct gene expression program for differentiation of the right specialized cell type is turned on.

PI_NAMEs: FULLER, MARGARET T (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: 3' Untranslated Regions;adult stem cell;Alternative Splicing;Architecture;Biological;candidate identification;Cell Communication;Cell Cycle;Cell Lineage;Cell model;cell type;Cells;Chromatin;Collaborations;Communication;CSPG6 gene;Cyclin B;Development;Drosophila genus;Failure;G2 Phase;gene correction;Gene Expression;Genes;Genetic Transcription;Germ Lines;Homologous Gene;Immunoprecipitation;in vivo;Laboratories;M cell;Maintenance;male;Malignant Neoplasms;Maps;Meiosis;Messenger RNA;Mitosis;Mitotic;Modeling;Molecular;novel;precursor cell;prevent;Process;Production;programs;Proliferating;promoter;Prophase;Protein Isoforms;Proteins;recruit;Regulation;repaired;Repression;RNA-Binding Proteins;self-renewal;Site;Spermatocytes;Spermatogonia;Structure;Supporting Cell;System;Tissues;Transcript;transcriptome sequencing;Translations

PROJECT_TITLE: Regulation of proliferation and differentiation in the male germ line adult stem cell lineage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Kidney Disease;Neurodegenerative

ORG_CITY: GREENSBORO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTH CAROLINA AGRI & TECH ST UNIV

ORG_STATE: NC

PHR: PROJECT NARRATIVE. Meprin metalloproteases have been implicated in the pathophysiology of chronic kidney injury induced by diabetes and neurodegenerative disease (e.g. Alzheimer’s disease). The proposed research program will determine; (1) how single nucleotide polymorphisms (SNPs) in the meprin genes impact interaction between the meprin enzymes and their substrates, (2) how cleavage of meprin substrates influence signaling pathways involved in disease progression, and (3) the potential use of meprins and meprin cleavage products in early diagnosis of tissue injury. This knowledge is important in developing therapeutic targets and diagnostic tools for diseases such as chronic kidney injury and Alzheimer’s disease.

PI_NAMEs: ONGERI, ELIMELDA MOIGE (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Actins;Alzheimer's Disease;Amyloid beta-Protein Precursor;Anti-Inflammatory Agents;Area;Award;biomarker development;brush border membrane;cancer cell;CCL2 gene;Chronic;Complex;Coupled;Cyclic AMP-Dependent Protein Kinases;cytokine;Cytoskeletal Proteins;Diabetes Mellitus;diabetic;Diabetic Nephropathy;diagnostic development;diagnostic tool;Disease;Disease Progression;E-Cadherin;Early Diagnosis;Endothelial Cells;Enzymes;Extracellular Matrix;Extracellular Matrix Proteins;Fibrosis;Functional disorder;Genes;Genetic Predisposition to Disease;Hypoxia;IL18 gene;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury to Kidney;insight;Interleukin-1 beta;Interleukin-6;Kidney Diseases;Knockout Mice;Knowledge;Leukocytes;Macrophage;Malignant Neoplasms;Mediating;Mediator;Mentors;Meprin;meprin alpha;Metabolism;Metalloproteases;Minority Groups;Molecular;Molecular Biology;monocyte;mouse model;Neurodegenerative Disorders;occludin;Organ;Osteosarcoma;Physiological;podocyte;precision medicine;programs;Protein Isoforms;Protein Kinase C;Proteins;Proteomics;Proximal Kidney Tubules;Pulmonary Fibrosis;Renal Carcinoma;Research;response;Severities;Signal Pathway;Signal Transduction;Signaling Protein;Single Nucleotide Polymorphism;Skin;Small Intestines;Substrate Interaction;Therapeutic;therapeutic target;Tight Junctions;tissue injury;tool;Transcend;translational study;TREM2 gene;Underrepresented Minority;villin

PROJECT_TITLE: Mechanistic Studies on Meprin Metalloproteases and Meprin-Substrate Interactions in Tissue Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Due to the development of highly effective treatments for HIV and the resulting increased longevity among people with HIV, this population now loses more life years to smoking than to HIV infection itself. Novel and effective models to deliver wider reaching smoking cessation interventions to individuals with HIV are highly needed and indicated as a priority for NIH. This study will generate new clinical evidence for a novel intervention for this population as well as guidance about how to implement it in real-world settings.

PI_NAMEs: ASHARE, REBECCA ;VILARDAGA, ROGER  (contact)

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: Abstinence;Address;Adherence;African American;Anti-Retroviral Agents;Area;arm;Behavioral;Biochemical;Cancer Control;cancer diagnosis;cancer health disparity;Cigarette;Clinic;Clinical;Clinical effectiveness;Clinical Practice Guideline;Cognitive deficits;Communities;community advisory board;compare effectiveness;Confidence Intervals;Consolidated Framework for Implementation Research;Control Groups;cost;craving;Data;design;Development;digital applications;digital intervention;digital treatment;Disease;effective therapy;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Electronic cigarette;evidence base;experience;Future;General Population;Guidelines;Health;health equity;Health Personnel;HIV;HIV Infections;Hybrids;implementation evaluation;implementation facilitators;implementation science;implementation strategy;Improve Access;Individual;interest;Intervention;Interview;Learning;Life;Longevity;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mental Health;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;National Cancer Institute;nicotine replacement;novel;Outcome;Patient Self-Report;Patients;Persons;Phase;Pilot Projects;pilot trial;Play;Population;Population Intervention;Prevalence;prevent;primary outcome;Public Health;Quality of life;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Research Design;Research Priority;research to practice;Sampling;secondary outcome;Secure;Services;Smoke;Smoking;smoking cessation;Smoking Cessation Intervention;smoking prevalence;smoking-related cancer;social;social stigma;Strategic Planning;Stress;substance use;Surveys;Technology;Testing;therapeutic biomarker;therapy adherence;therapy design;Tobacco use;Tobacco Use Disorder;treatment effect;Uncertainty;United States National Institutes of Health;user centered design;Voice;Work

PROJECT_TITLE: Hybrid Trial of a Tailored Smoking Cessation Digital Therapeutic for Persons Living with HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-S (03)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This proposal seeks support for the purchase of a JEOL 500 MHz NMR spectrometer that was installed accord- ing to an evaluation agreement without any down payment. This spectrometer is serving as an essential core resource to support diverse biomedical research programs at the Johns Hopkins Medical School campus. The instrument will provide essential structural characterizations of small molecule drug candidates, new clinical im- aging agents, and small molecule metabolites isolated from cells and tissues. The programs supported involve cancer, neuroscience, metabolomics, and general drug discovery.

PI_NAMEs: BHAT, SHRIDHAR  (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Achievement;Agreement;Amplifiers;base;Basic Science;Biomedical Research;Chemicals;Chemistry;Clinical Sciences;Computer software;COSY;Development;digital;drug development;drug discovery;drug metabolism;Evaluation;experimental study;Friends;Funding;Generations;Goals;Health;imaging agent;instrument;instrumentation;interest;Investigation;Malignant Neoplasms;Mediation;medical schools;metabolomics;Molecular;National Institute of Allergy and Infectious Disease;National Institute of Biomedical Imaging and Bioengineering;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Drug Abuse;National Institute of General Medical Sciences;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;NMR Spectroscopy;NOESY;novel therapeutics;Nucleic Acids;Outcome Assessment;payment;Peptides;Pharmaceutical Preparations;Pharmacology;Physiologic pulse;Polymers;Proteins;repaired;Request for Proposals;Research;Research Personnel;Resources;Role;Science;Services;small molecule;Structure;Synthesis Chemistry;System;TOCSY;tool;United States National Institutes of Health

PROJECT_TITLE: Acquisition of a 500 MHz NMR Spectrometer to Support Small-Molecule Chemistry at Johns Hopkins Medical School

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-V (32)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Lung;Pulmonary Hypertension

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE Right ventricular (RV) failure is widely recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet we fall short in trying to identify and treat it. The current proposal will (1) determine the best clinical indicators of intrinsic RV cardiomyocyte contractile failure in humans with HFrEF-PH, (2) clarify underlying mechanisms, and (3) test novel treatments on RV cardiomyocytes. The long-term goal of this proposal will be to better identify and treat RV failure in humans suffering from HFrEF-PH.

PI_NAMEs: HSU, STEVEN  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Bicycling;Biophysical Process;Biophysics;Biopsy;Calcium;Cardiac Myocytes;cardiac tissue engineering;Clinical;Clinical assessments;clinical translation;Coupling;Cyclic AMP-Dependent Protein Kinases;Data;Depressed mood;Diagnosis;Disease;drug testing;Echocardiography;EFRAC;end stage disease;Exercise;Failure;Family suidae;Frustration;Functional disorder;Goals;Heart;Heart failure;heart failure with reduced ejection fraction;hemodynamics;Human;Human Engineering;improved;Incubated;indexing;insight;Intervention;Isometric Exercise;left ventricular assist device;Length;Link;Measures;Mechanics;Mediator;Mental Depression;Modification;Muscle;Muscle Cells;Mutate;Myocardium;Myosin ATPase;myosin-binding protein C;National Heart, Lung, and Blood Institute;novel;Outcome;Patient-Focused Outcomes;Patients;Permeability;Pharmaceutical Preparations;Phenotype;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiologic intraventricular pressure;pressure;primary pulmonary hypertension;prognostic;prospective;Protein phosphatase;Proteins;Protocols documentation;Pulmonary Hypertension;recruit;Relaxation;Reporting;Research;Research Personnel;response;Rest;Right Ventricular Dysfunction;right ventricular failure;Right Ventricular Function;Rodent;Role;Sarcomeres;Scaffolding Protein;Secondary to;Site;Skin;Strategic vision;Stretching;Sturnus vulgaris;Supination;Testing;Therapeutic;Thick Filament;Time;Tissues;tool;Ventricular;Work

PROJECT_TITLE: Myocyte Mechanics of Right Ventricular Contractile Failure in Pulmonary Hypertension due to Heart Failure with Reduced Ejection Fraction

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Pathogens often exist as diverse populations, where each strain or isolate may differ in the sequence of its genome. Determining how these genetic differences affect the behavior, transmission, drug resistance, and overall risk profile of viral, bacterial, fungal, and parasitic pathogens is important to human health. The proposed research will lead to a greater understanding of what makes a pathogen successful in nature, and ultimately to improved countermeasures against infectious diseases.

PI_NAMEs: LAURING, ADAM  (contact);SNITKIN, EVAN

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: 2019-nCoV;Adult;Affect;Agriculture;anti-microbial drug;Antimicrobial Resistance;Basic Science;Behavior;Biological Assay;built environment;Candida auris;carbapenem resistant Enterobacterales;Cessation of life;Clinical Research;Communicable Diseases;Comparative Genomic Analysis;Complex;complex data;COVID-19 pandemic;Data;Data Set;data sharing;Decontamination;Detection;Disease;Disease Outbreaks;disease transmission;Drug resistance;drug resistant pathogen;Drug usage;Education and Outreach;Environment;Epidemic;epidemic potential;Epidemiology;Epitopes;Evolution;experimental study;Explosion;Felis catus;Fetal Development;fitness;Formulation;functional genomics;Genes;Genetic;Genetic Determinism;genetic selection;Genetic Variation;Genome;genome sequencing;genome wide association study;Genomic approach;Genomic Centers for Infectious Diseases;Genomics;Germ;Guide prevention;Health;Health care facility;Healthcare;Hospitals;host colonization;Human;Immune;Immunity;Immunocompromised Host;improved;Infection;influenzavirus;Infrastructure;innovation;Intervention;Investigation;Knowledge;Laboratories;Link;Long-Term Care;Maps;Mediating;medical vulnerability;Methods;Michigan;microbial;Microbial Genome Sequencing;Microbiology;Modeling;Mutation;Natural experiment;Nature;neutralizing antibody;novel;Parasites;pathogen;pathogen genomics;pathogenic fungus;Pathway interactions;Patients;Phenotype;Phylogenetic Analysis;Population;Population Heterogeneity;prevent;Process;Property;Protocols documentation;Public Health;Recurrence;Reporting;Research;Research Personnel;Resistance;resistance gene;resistance mutation;Resource Sharing;Resources;Respiratory syncytial virus;respiratory virus;Risk;Risk Assessment;Sampling;Skin colonization;South America;success;surveillance data;technological innovation;Technology;theories;tool;Toxoplasma;Toxoplasma gondii;trait;transmission process;Vaccines;Viral;Virulence;Virus;whole genome;Work;Zoonoses

PROJECT_TITLE: The Michigan Infectious Disease Genomics (MIDGE) Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 MFH-M (J1)]


NIH_SPENDING_CATS: Infectious Diseases

PI_NAMEs: LAURING, ADAM  (contact)

PROJECT_TERMS: Accountability;Administrative Coordination;Arbitration;Benchmarking;Biological Assay;Budgets;Communicable Diseases;Communication;Communities;community partners;Consultations;Data;data sharing;Development;Disputes;Emergency response;Ensure;Epidemic;functional genomics;Future;Genomic Centers for Infectious Diseases;Genomics;Goals;Infrastructure;Lead;Leadership;Maintenance;meetings;member;Michigan;Monitor;National Institute of Allergy and Infectious Disease;Office of Administrative Management;outreach;pandemic response;pathogen;Peer Review;Productivity;programs;Progress Reports;Quality Control;Reporting;Research;Research Personnel;Resolution;Resource Sharing;Resources;Specimen;Students;success;symposium;synergism;Technology;Training;training opportunity;United States Dept. of Health and Human Services;Update;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: SNITKIN, EVAN  (contact)

PROJECT_TERMS: analysis pipeline;Automation;Bioinformatics;Biological Assay;Communicable Diseases;Communities;complex data;Computer software;Custom;Data;data dissemination;data hub;data management;data pipeline;data quality;Data Set;data sharing;Dedications;Deposition;Development;DNA Sequencing Facility;Ensure;Environment;Epidemic;Evolution;experience;Generations;Genetic Variation;genome sequencing;genome wide association study;Genomic Centers for Infectious Diseases;genomic data;genomic variation;Genomics;Genotype;Goals;Growth;gut microbiota;high throughput screening;improved;Individual;Infrastructure;Knowledge;Laboratories;Laboratory Technicians;Leadership;Manuscripts;Maps;Measurement;member;Metabolic;metagenome;Methods;Michigan;microbial;microbial genome;microbiome analysis;Mission;novel;pathogen;Phenotype;phenotypic data;Phylogenetic Analysis;Postdoctoral Fellow;Productivity;Protocols documentation;public database;Quality Control;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Running;Sequence Analysis;Services;success;System;Technical Expertise;Technology;Training;transcriptome sequencing;web site;whole genome;Work;Writing

PROJECT_TITLE: Technology & Data Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Address;Adult;Amino Acid Substitution;Animal Model;Antibodies;Antibody Response;Antibody-mediated protection;Attention;Bayesian Modeling;Biological Assay;Chimeric Proteins;COVID-19;COVID-19 surveillance;Data;Data Set;Development;Disease;Epidemic;Epitopes;Event;Evolution;experimental analysis;fitness;Foundations;Frequencies;functional genomics;Genome;Genomic Centers for Infectious Diseases;genomic data;Genomics;Geography;Glycoproteins;Goals;Health system;Hemagglutinin;heuristics;Household;Immune;Immunity;improved;Individual;Infection;Influenza;influenza surveillance;influenzavirus;innovation;Knowledge;Laboratories;Libraries;Location;Maps;Measures;Membrane Glycoproteins;Michigan;Modeling;Mutation;mutation screening;Natural Selections;Neuraminidase;novel;Phenotype;Population;Population Heterogeneity;Pregnant Women;Proteins;Public Health;Race;Recording of previous events;Research;Respiratory Syncytial Virus Infections;respiratory virus;Sampling;seasonal influenza;Serum;Site;socioeconomics;success;surveillance data;System;unvaccinated;Vaccinated;Vaccination;Vaccines;Variant;Viral;viral fitness;viral genomics;Virus;whole genome

PROJECT_TITLE: P1-Genomic determinants of epidemic success in respiratory viruses


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention

PROJECT_TERMS: Antibiotic Resistance;Antibiotics;Bacteria;Bacterial Genome;beta-Lactams;carbapenem resistance;carbapenem resistant Enterobacterales;carbapenemase;Centers for Disease Control and Prevention (U.S.);Classification;Clinical;Collection;Containment;cost;Data;Death Rate;density;Disease Outbreaks;emerging antibiotic resistance;empowerment;Environment;Epidemic;epidemic potential;Evolution;fitness;Future;Gastrointestinal tract structure;Genes;Genetic;Genetic Determinism;genetic signature;Genetic Variation;Genome;genome wide association study;Genomic Centers for Infectious Diseases;Genomic Segment;Genomics;Guide prevention;gut colonization;gut microbiota;Health care facility;health care settings;Healthcare;high risk;Hospital Moving;Hospitalization;Hospitals;Human;improved;insight;Intervention;Laboratories;Literature;Measurement;member;Metadata;Michigan;Monitor;mortality;Nature;novel;patient population;Patients;Pattern;Phenotype;Phylogeny;Plasmids;Population Surveillance;prevent;Probability;Public Health;Publishing;Resistance;resistance mutation;Risk;Risk Assessment;Risk Factors;Role;sample collection;Sampling;Testing;therapy development;trait;transmission process;Validation;Variant;virtual;World Health Organization

PROJECT_TITLE: P2-The impact of genetic background on the emergence and spread of carbapenem-resistant Enterobacterales


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome;Prevention

PI_NAMEs: OMEARA, TERESA R. (contact)

PROJECT_TERMS: Address;Adherence;Adhesions;Adhesives;anti-fungal agents;Binding;Biology;Candida auris;Cellular biology;Characteristics;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coupling;Data;Decontamination;design;Development;Disease;Disease Outbreaks;disorder risk;emerging pathogen;epidemic potential;Evolution;experimental study;forward genetics;Foundations;functional genomics;Fungal Drug Resistance;fungus;Future;Genes;Genetic;Genetic Determinism;Genetic Screening;genetic variant;genome sequencing;genome wide association study;genome-wide;Genomic approach;Genomic Centers for Infectious Diseases;Genomics;Goals;health care settings;Healthcare;Hospitals;Human;in vitro Model;in vivo Model;Individual;Infection;innovation;Insertional Mutagenesis;Intervention;Investigation;keratinocyte;Knowledge;Life;Link;Measures;Methods;Michigan;microbial;Microbial Biofilms;Microbial Genome Sequencing;Modeling;novel;Organism;outbreak concern;pathogen;pathogenic fungus;Pathway interactions;Phenotype;Population Genetics;prevent;Process;Proteins;Public Health;Regulation;Reporting;reverse genetics;Risk Factors;Sepsis;Site-Directed Mutagenesis;Skilled Nursing Facilities;Skin;Skin colonization;Surface;Testing;Time;tool;transmission process;Variant;variant of interest;variants of concern;Virulence;Virulence Factors;whole genome;Work

PROJECT_TITLE: P3-Genetic and genomic determinants of colonization in Candida auris, an emerging fungal pathogen


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: ROCHESTER

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: NARRATIVE Microvascular insufficiency underlies many common, chronic diseases, including diabetic retinopathy and neuropathy, chronic venous insufficiency and leg ulcers, cerebral infarction, and coronary microvascular disease. Creating microvessel networks that structurally and functionally mimic the native microvasculature is critical for a wide range of tissue engineering and regenerative medicine applications. The overall goal of this project is to advance a novel ultrasound technology to fabricate complex, functional microvessel networks directly in vivo.

PI_NAMEs: DALECKI, DIANE  (contact);HOCKING, DENISE C

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3-Dimensional;Acoustics;Address;adverse outcome;Affect;Animal Model;Area;Autologous;Beds;Blood capillaries;Blood Vessels;Cell Survival;cell type;Cells;Cerebral Infarction;Chronic;Chronic Disease;Clinical;clinical translation;clinically relevant;Collagen;Complex;Coronary;cost effective;design;Development;Diabetic Neuropathies;Diabetic Retinopathy;efficacy evaluation;Endothelial Cells;Engineering;fabrication;Fatty acid glycerol esters;Formulation;Frequencies;functional mimics;Geometry;Goals;Holography;Hydrogels;improved;In Vitro;in vivo;Injectable;Injections;innovation;instrumentation;Ischemia;iterative design;Leg Ulcer;lens;Liquid substance;mechanical force;Mediating;Methods;Microscopic;Microvascular Dysfunction;Modeling;Morphology;mouse model;Mus;Necrosis;neovascularization;novel;Operative Surgical Procedures;particle;Pattern;Perfusion;Phase;Phase Transition;Plastic Surgical Procedures;Pre-Clinical Model;Protocols documentation;Radiation;Reconstructive Surgical Procedures;Regenerative Medicine;research and development;Resected;Resolution;revascularization;Site;Skin;Solid;sound;Source;Stromal Cells;System;Technology;Testing;Tissue Engineering;Tissue Model;tissue regeneration;Tissues;tool;Transducers;Translating;Ultrasonic Transducer;Ultrasonography;ultrasound;Vascularization;Venous Insufficiency;Visualization

PROJECT_TITLE: In Vivo Acoustic Patterning for Tissue Vascularization

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Aging;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Thymic epithelial cells (TECs) are critical for the development of T cell-mediated immunity, and age-associated declines in their function cause thymus atrophy and diminish T cell responses to infection and vaccination in the elderly. This project aims to identify the underlying mechanisms that cause age-associated TEC dysfunction to identify therapeutic strategies for thymus regeneration, and to test those strategies for their capacity to improve cell responses to viral challenge in aged animals.

PI_NAMEs: GRIFFITH, ANN VENABLES (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Ablation;Age;age related;age related decline;aged;aging population;animal old age;Antigen Presentation;Atrophic;Autoantigens;Autophagocytosis;autoreactive T cell;Biology;Cell Size;Cells;Cellular Immunity;Cellular Morphology;Cellularity;Clinical;clinically relevant;cofactor;Complex;COVID-19 pandemic;Data;design;Development;Digestion;Doxycycline;Elderly;Engineering;Epithelial Cells;FGF21 gene;fibroblast growth factor 21;Flow Cytometry;FRAP1 gene;Frequencies;Functional disorder;Genetic Models;Genetic Transcription;Growth;Growth Factor;Histones;Image;Immunity;Immunoassay;improved;in vivo;Infection;inhibitor;innovation;Knockout Mice;Labyrinth;Life;life span;Lymphoid;Maintenance;Maps;Mediating;Mediation;Metabolism;Microscopy;middle age;Modeling;Morphology;Mus;Natural regeneration;old mice;older patient;Outcome;Output;overexpression;paracrine;Pathway interactions;Pharmaceutical Preparations;Phase;Phenotype;Physiological;Population;Predisposition;Process;progenitor;programs;Proliferating;Public Health;Publishing;receptor;Regimen;Reporter;response;Role;Self Tolerance;Signal Pathway;Signal Transduction;Site;stem cell differentiation;stem cells;Stromal Cells;Structure of thymic cortex;T cell response;T memory cell;T-Cell Development;T-Lymphocyte;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Thymic epithelial cell;thymic regeneration;Thymic Tissue;Thymocyte Selection;Thymus Gland;Vaccination;Vaccines;Viral;Virus Diseases;Work

PROJECT_TITLE: The role of paracrine growth factor signaling in thymus function and age-associated dysfunction

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative This research project builds on our current community partner relationships and uses a Community-Based Participatory Research (CBPR) framework to culturally adapt and test the feasibility of a Behavioral Activation and Therapeutic Exposure for Grief (BATE-G) intervention among American Indian and Alaska Native (AI/AN) people who are experiencing impairing grief-related symptoms diagnosed as Persistent Complex Bereavement Disorder (PCBD). BATE-G employs trained AI/AN community paraprofessionals to deliver intervention content via telehealth, increasing access to culturally responsive evidence-based treatments for this often-underserved population. This project will also contribute to the research and training development of an early career investigator whose career goals center around understanding and addressing health inequalities in underserved communities with a focus on trauma and grief.

PI_NAMEs: GAMEON, JULIE A (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Accidental Injury;Accidents;Acute;Address;Adult;Affect;Aftercare;Age;Alaska Native;Alaska Native population;American Indian Population;American Indians;Area;Behavioral;behavioral health;behavioral health intervention;Bereavement;Biological;Black Populations;career;career development;Cessation of life;Chronic Disease;Clinical;Clinical Research;Clinical Trials;clinically significant;Cohort Studies;commune;Communities;community advisory board;community based participatory research;community partners;Complex;coping;COVID-19;culturally appropriate intervention;Data;Death Rate;depressive symptoms;design;Development;Diagnosis;Disabling;disabling symptom;Disease;Elements;Emotional;ethnic minority population;evidence base;Evidence based treatment;experience;Family;Family member;Family Relationship;feasibility testing;feasibility trial;Feedback;Focus Groups;follow-up;Friends;Future;Generations;Goals;Grant;Grief reaction;Health;Health equity research;health inequalities;Health Services Accessibility;Hispanic Populations;Homicide;Impairment;implementation science;improved;Interpersonal Violence;Intervention;Interview;Light;Love;loved ones;Manuals;Measures;member;Mental Health;Mental Health Services;Mentors;Mentorship;Mission;mortality;National Institute on Minority Health and Health Disparities;Outcome Assessment;Participant;Persons;physical conditioning;Pilot Projects;pilot test;pilot trial;Population;Post-Traumatic Stress Disorders;Process;psychologic;Public Health;racial minority population;Randomized, Controlled Trials;recruit;Reduce health disparities;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;research study;Resources;Risk;satisfaction;Series;Shapes;skills;Social support;Spirituality;stress disorder;Structure;substance use;Suicide;Symptoms;Technology;telehealth;Telemedicine;Testing;Texas;Therapeutic;therapy design;Training;Training Support;Trauma;Traumatic injury;treatment planning;underserved community;Underserved Population;United States;Work

PROJECT_TITLE: Cultural Adaption of Behavioral Activation and Therapeutic Exposure for Grief Among American Indian People

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (J1)]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Our proposed research aims to revolutionize proton therapy by developing a compact fixed beamline system that enables ultra-fast dose delivery. By reducing single-field delivery time to a few seconds and total treatment time by up to 50% compared to current systems, this technology will enhance patient care, improve treatment quality and increase patient throughput, which, combined with a small facility footprint, will ultimately make proton therapy more accessible and cost-effective. This innovative solution has the potential to significantly advance the field of cancer treatment and improve public health outcomes by optimizing the delivery of proton therapy to a wide range of patients.

PI_NAMEs: NESTERUK, KONRAD PAWEL (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: Address;beamline;Benchmarking;cancer therapy;Clinical;clinical implementation;Code;Collimator;commercial prototype;commercialization;cost;cost effective;Cyclotrons;Dedications;design;Development;Dose;energy efficiency;Engineering;Ensure;Equipment;Foundations;Future;Goals;Hospitals;improved;Industrialization;innovation;Lateral;magnetic field;Magnetism;Malignant Childhood Neoplasm;Maps;Medical;Modeling;Monte Carlo Method;Motion;Movement;novel;Optics;Organ;Outcome;Output;particle;Patient Care;Patient-Focused Outcomes;Patients;Performance;proton therapy;prototype;Public Health;Radiation;Radiation therapy;Research;Rotation;Scanning;side effect;simulation;Specific qualifier value;Speed;Synchrotrons;System;Techniques;Technology;technology validation;Testing;therapy development;Thick;Time;Tissues;Translations;treatment choice;treatment planning;United States;Universities;Validation

PROJECT_TITLE: A compact beam delivery system enabling ultra-fast dose delivery for upright proton therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-E (57)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE: The UMass Flow Cytometry Research Core Facility proposes to purchase an Amnis Imagestream MK II imaging flow cytometer to meet the research needs of 12 Major and 7 Minor users, 17 of which are NIH- funded. The ImageStream will support experimentation in diverse areas of medical research including cancer, autoimmunity, bacterial and fungal pathogens, anemia, malaria, HIV, COVID, and more.

PI_NAMEs: SCHRADER, CAROL E (contact)

PROJECT_TERMS: 11 year old;Aging;Anemia;Area;Autoimmunity;bench to bedside;Biomedical Research;Cell Communication;Cells;cellular imaging;Communicable Diseases;Complex;Computer software;Core Facility;Coupled;Coupling;COVID-19;data acquisition;Data Analyses;Diabetes Mellitus;Disease;DNA Repair;Equipment;Flow Cytometry;Funding;gene therapy;Grant;HIV;Image;improved;innovation;Institution;instrument;instrumentation;Lasers;Machine Learning;Malaria;Malignant Neoplasms;Manufacturer;Medical Research;medical schools;Microscopy;Minor;Molecular;Morphology;pathogenic bacteria;pathogenic fungus;Phagocytosis;Principal Investigator;Reproducibility;Research;Research Personnel;Research Project Grants;Resolution;Speed;Statistical Data Interpretation;Techniques;Time;Translational Research;United States National Institutes of Health

PROJECT_TITLE: Amnis ImageStreamX MkII Imaging Cytometer for UMass Chan Flow Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-D (30)]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Infectious Diseases;Pediatric

ORG_CITY: Aurora

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative: Transmission electron microscopes are the most powerful microscopes, producing high resolution images at a resolution a thousand times higher than a light microscope, allowing study of intricate details within a cell. Changes in these sub-cellular features provide important clues to mechanisms of disease, dysfunction in aging, cancer, and genetic disorders.

PI_NAMEs: FARHANG DAREHSHOURI, ANZA  (contact)

PROJECT_TERMS: 20 year old;aged;Basic Science;Biological;Cellular biology;Clinical Sciences;Colorado;Computer software;Contract Services;Core Facility;Demyelinations;design;Developmental Biology;Disease;Drug Delivery Systems;Electron Microscope;Electron Microscopy;Epidermolysis Bullosa;Fee-for-Service Plans;Funding;Health;HIV-1;Image;Infection;Institution;irradiation;Kidney Diseases;Laboratories;Laboratory Research;Medical;Meninges;Microscope;Optics;Regulation;remyelination;Research;Research Personnel;Rotation;Sampling;Services;Staphylococcus aureus;System;transmission process;United States National Institutes of Health;user friendly software

PROJECT_TITLE: 120 kV Transmission Electron Microscope for CU Anschutz Electron Microscopy Core Facility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-B (30)]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology

PHR: The i3 seeks to replace a heavily used aging single quadrupole electrospray LC-MS system with a tandem ultrahigh pressure liquid chromatography and mass spectrometer (LC-MS) system that offers substantial advantages over our current experimental configurations.

PI_NAMEs: CHEN, JOHN W (contact)

PROJECT_TERMS: 10 year old;Acceleration;Age;Aging;chemical reaction;chemical synthesis;Chemistry;Chromatography;Clinical Trials;Computers;Contract Services;Core Facility;cost;Data;Electrons;Equipment;Failure;Funding;General Hospitals;High Pressure Liquid Chromatography;Image;imaging probe;innovation;instrument;instrumentation;Investigational New Drug Application;Journals;Legal patent;Life;liquid chromatography mass spectrometry;Maintenance;Massachusetts;Molecular;molecular imaging;Monitor;Motor;Needles;Paper;Peptides;Pharmaceutical Chemistry;Pharmacologic Substance;pressure;Pump;repaired;Reporting;Research;Research Activity;Scientist;small molecule;Solvents;System;United States National Institutes of Health

PROJECT_TITLE: LC/MS Replacement for Institute for Innovation in Imaging Core Facility.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-T (30)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Diabetes;Heart Disease;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_DEPT: PEDIATRICS

PHR: Project Narrative We will use a specialized instrument called an isotope ratio mass spectrometer that measures compounds in very small quantities to help us understand how the body uses nutrients to produce energy. This, in turn, will allow for the development of therapies to prevent the onset of obesity and diabetes.

PI_NAMEs: BROWN, LAURA DAVIDSON (contact)

PROGRAM_OFFICER_NAME: CHEN, YONG

PROJECT_TERMS: Adult;Affect;Carbon;Carbon Isotopes;Cardiovascular Diseases;Childhood;cost effective;Diabetes Mellitus;diabetes risk;Diet;Dietary Intervention;Disease;Exercise;fetal;Fetal Growth Retardation;Funding;Goals;Growth Factor;Heart Diseases;Hydrogen;Individual;Infusion procedures;Institution;instrument;Isotopes;Life;mass spectrometer;Measurement;Metabolism;Minor;Nitrogen;Obesity;obesity risk;oxidation;Oxygen;Perinatal;Placental Insufficiency;Plasma;Process;Research Project Grants;response;Risk;risk minimization;Sampling;Scientist;stable isotope;Sulfur;Supplementation;Technical Expertise;Therapeutic Intervention;total energy expenditure;Tracer;United States National Institutes of Health;Urine;Whole Blood

PROJECT_TITLE: DELTA Q Isotope Ratio Mass Spectrometer


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Human Fetal Tissue;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE The purpose of our proposed study is to refine induced pluripotent stem cell (iPSC)-neuronal model systems by providing developmentally appropriate extracellular matrix (ECM) cues. We will first define the composition and nature of remodeling of the mammalian CNS matrisome in vivo, and then leverage our combined expertise in iPSC technologies and biomaterials to establish ECM mimetic matrices that can recapitulate the architecture and modulatory activity of the physiological matrisome and facilitate the maturation and aging of stem cell derived neuronal models in vitro.

PI_NAMEs: KISKINIS, EVANGELOS  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: 3-Dimensional;3D Print;Adult;age related;Aging;Architecture;Astrocytes;Biochemical;Biocompatible Materials;Biological Models;Cell Reprogramming;Cells;Central Nervous System;Complex;Cues;Data Set;design;Development;digital;Electrophysiology (science);Embryo;Exhibits;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;fetal;Gene Expression;Generations;Genetic Transcription;Geometry;Human;Hydrogels;immunocytochemistry;Immunohistochemistry;improved;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;induced pluripotent stem cell technology;Investigation;Laminin;Light;Mass Spectrum Analysis;mechanical properties;Mediating;Metabolic;Methods;mimetics;Modeling;Morphology;Motor Neurons;Mus;Nature;Nervous System Disorder;Neurodegenerative Disorders;neurodevelopment;Neuroglia;neuron development;Neurons;novel;old mice;Organoids;patch clamp;Phase;Physiological;Physiology;postnatal;Process;protein expression;Protein Secretion;Proteins;Proteomics;rational design;Recombinant Proteins;Reproducibility;Research;Running;Sampling;scaffold;Signal Transduction;spatiotemporal;Spinal;Spinal Cord;stem cell aging;stem cells;Structure;sugar;Synapses;System;Technology;Testing;Tissues;transcriptome sequencing;Tubular formation;Work

PROJECT_TITLE: Refining iPSC-Based Spinal Cord Model Systems by Fabricating Developmentally Programmed Extracellular Matrix Cues

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;HIV/AIDS;Machine Learning and Artificial Intelligence;Neurosciences;Obesity;Pediatric

PHR: PROJECT NARRATIVE The proposed 3 Tesla, whole-body, wide-bore magnetic resonance imaging system (3T GE SIGNA Premier XT) would fulfill unmet research needs at the University of Colorado Anschutz Medical Campus while providing greater scientific and funding opportunities for investigators across a wide range of departments and institutions. Specifically, the new system would provide much needed additional scanning capacity and offer higher signal-to-noise ratios, less distortion, shorter exam times, facilitate substantially quieter scanning, and allow access to newer imaging techniques not available on our current platform. These benefits will be particularly important for research involving behavioral health, obesity/metabolic disorders, and neurodevelopment.

PI_NAMEs: TREGELLAS, JASON R (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: Acceleration;analog;Artificial Intelligence;auditory processing;Behavior;Brain region;Childhood;Collaborations;Colorado;data quality;deep learning;digital;Disease;Dropout;Eating;Environmental Risk Factor;Exposure to;Funding Opportunities;Image;imaging system;improved;Infant;innovation;Institution;instrument;interest;Loudness;Magnetic Resonance Imaging;Medical;medical schools;Mental disorders;Metabolic Diseases;Morphologic artifacts;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;Noise;Obesity;Participant;Performance;Population;prenatal exposure;processing speed;reconstruction;Renal function;Research;Research Personnel;Running;Scanning;Science;Signal Transduction;Sleep;Stress;Substance Use Disorder;System;Universities;vibration

PROJECT_TITLE: 3T GE SIGNA Premier XT MRI

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (31)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anorexia;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Eating Disorders;Estrogen;Mental Health;Nutrition;Osteoporosis;Pediatric;Prevention;Women's Health Research

PHR: Narrative Teenagers and young adult women whose menstrual periods cease due to restrictive eating disorders, such as anorexia nervosa, and/or from excessive exercise, have low bone density and increased fracture risk. This double-blind, placebo-controlled study will examine whether administration of a medication (romosozumab) for 6 months that increases bone formation and reduces bone breakdown, followed by a single dose of an additional medication (zoledronate) to extend the effects of romosozumab will provide a necessary boost to allow bone health to normalize in teenagers and young adult women with these disorders who are also receiving estrogen replacement.

PI_NAMEs: MILLER, KAREN K (contact);MISRA, MADHUSMITA

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Acute;Adolescence;Adolescent and Young Adult;adolescent woman;Adult;Adult women;Age;Age Years;Amenorrhea;Anorexia Nervosa;bisphosphonate;Blinded;bone;Bone Density;Bone Formation Stimulation;bone geometry;bone health;bone mass;bone metabolism;Bone Resorption;bone strength;Calcium;comorbidity;Complication;Data;Disease;Dose;Double-Blind Method;Dual-Energy X-Ray Absorptiometry;Eating Disorders;Elements;Endocrine;Estradiol;Estrogen Replacements;excessive exercise;Exercise;Female Adolescents;Femur;Fracture;fracture risk;functional hypothalamic amenorrhea;girls;Guidelines;Hip region structure;Hormonal;Hormones;Impairment;improved;Individual;Infusion procedures;Injections;Intervention;Intravenous;Intravenous infusion procedures;Life;Measures;Menopause;Menstruation;Monoclonal Antibodies;Neck;Oral;Osteoblasts;Osteoclasts;Osteogenesis;Outcome;Participant;peer;Periodicity;Peripheral;Pharmaceutical Preparations;Physiological;Pilot Projects;placebo controlled study;Placebos;Postmenopause;Prevalence;prevent;Progesterone;Progestins;prospective;Prospective Studies;Randomized;Randomized, Controlled Trials;Recovery;Relapse;Resolution;restrictive eating;Site;skeletal;Societies;standard of care;Teenagers;Testing;Therapeutic;Thick;Time;Vertebral column;Visit;Vitamin D;Vitamin D supplementation;Weight;Weight maintenance regimen;WNT Signaling Pathway;Woman;Women's Group;X-Ray Computed Tomography;young adult;young woman;Zoledronate;Zoledronic Acid

PROJECT_TITLE: Romosozumab as an adjunct to physiologic estrogen replacement in adolescents and young adults with functional hypothalamic amenorrhea

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Muscular Dystrophy;Neurodegenerative;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE The SBP Functional Genomics Shared Resource conducts various high-throughput chemical and genetic screens using the Hamilton STAR and Agilent Bravo equipment, which have reached their hardware capacity and limits and are therefore obsolete. Users at the shared resource are unable to operate these semi-automated platforms to execute high-valued arrayed library screening and resolve critical questions raised in current NIH- funded research. Fortunately, the proposed high-throughput automation model, Beckman Coulter Biomek i7, will be able to streamline the entire screening process, including assay development, arrayed library preparation and screening, and target validation in cellular disease models. The acquisition of the Beckman Coulter Biomek i7 will help propel the discovery of novel targets and their underlying mechanisms, advancing our understanding of a wide spectrum of human diseases. The disease indications being studied at SBP that will benefit from this automation include COVID-19, childhood diseases, including leukemia, brain cancer, and Duchenne Muscular Dystrophy, as well as adult diseases such as breast cancer, aging-specific chronic inflammation, Alzheimer’s disease, and its related dementia. Deployment of the Biomek i7 automation will help accelerate the development of innovative therapeutics, which is the primary objective of these NIH-funded projects.

PI_NAMEs: HUANG, CHUN-TENG  (contact)

PROJECT_TERMS: Accounting;Aging;aging related disease;Alzheimer's disease related dementia;Automation;Bacteria;Biological Assay;Cell Culture Techniques;Cells;Child Health;Computer software;Core Facility;COVID-19;CRISPR library;Degenerative Disorder;Disease;Equipment;functional genomics;Funding;Healthcare;human disease;Hybrids;innovation;Libraries;Liquid substance;Malignant Neoplasms;Mammalian Cell;Medical;Medical Research;Modeling;Muscular Dystrophies;new therapeutic target;novel;Phenotype;Plasmid Cloning Vector;Preparation;Production;recombinant virus;Relapse;Research;screening;stem cells;System;Technology;time use;United States National Institutes of Health;Viral Vector

PROJECT_TITLE: Beckman Coulter Biomek i7 Hybrid automated workstation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-D (30)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

PHR: Microprocessor-controlled knees (MPKs) do not typically utilize motors to power joint rotation, but they automatically adjust resistance or damping in the joint to improve swing- and/or stance-phase control as appropriate for the prosthesis user during gait. The Ossur Power Knee is the only commercially-available MPK that uses a motor to provide active power generation during walking and other activities. The purpose of this proposed investigation is to perform and compare biomechanical evaluations of the Power Knee and Ossur Rheo XC, a passive MPK, during walking and other activities by prosthesis users. Furthermore, we will compare mobility between male and female subjects to determine if there are differences in prosthetic knee usage on the basis of sex. The Veterans Health Administration (VHA) reported that between 1989-1998, 29% of amputations were performed at the transfemoral level. This emphasizes the strong relevance and potentially high impact of this research study on current Veterans, which is directly applicable to the VHA’s Patient Care Mission.

PI_NAMEs: GARD, STEVEN A. (contact)

PROJECT_TERMS: absorption;Address;Affect;Amputation;Amputees;Anatomy;Area;Articular Range of Motion;battery life;biological sex;biomechanical test;Body Weight decreased;Characteristics;Complex;Contralateral;cost;Data;design;Development;Devices;diaries;Evaluation;Exertion;Experimental Designs;Female;Femur;foot;functional restoration;Gait;Gender;Generations;Home;Human;Iceland;improved;improved mobility;Investigation;Joints;kinematics;Kinetics;Knee;Knee joint;Knee Prosthesis;Knowledge;Laboratory Research;Leg;limb loss;Limb Prosthesis;Limb structure;male;Mechanics;men;Metabolic;Microprocessor;Mission;Modeling;Motion;Motor;Movement;Noise;Patient Care;Perception;Performance;Persons;Phase;powered prosthesis;Prosthesis;prosthesis wearer;Quality of life;Questionnaires;Reporting;Research;research study;Resistance;response;Rotation;Services;sex;Shock;Speed;Technology;Toes;Veterans;Veterans Health Administration;Walking;walking performance;Woman;women subjects

PROJECT_TITLE: Do Transfemoral Prostheses with Powered Prosthetic Knee Flexion and Extension Improve Mobility?  A Biomechanical Evaluation of the Ossur Power Knee

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative  Currently, a great majority of research projects that study mechanisms of diseases are dependent on microscopy techniques that allow them to look at the organization, localization and dynamic behavior of proteins inside cells, tissues and entire organisms to better understand how they affect and control human body health and disease. The microscopes utilized in research are extremely valuable and often get surpassed by technological improvements that can easily change the quality and speed of the research produced. The current request is to acquire a microscope called Nikon SoRa W1-spinning disk confocal with photo-stimulation and photo-ablation that will replace our obsolete 13 years old system with improved technology capable of producing higher quality and super-resolution (at 120 nm scale) live images that are essential for the comprehension of how cancer cells function and develop.

PI_NAMEs: PAULUCCI-HOLTHAUZEN, ADRIANA  (contact)

PROJECT_TERMS: 13 year old;3-Dimensional;Actins;Adherens Junction;Apical;cancer cell;Cancer Center;Cell Physiology;Cells;Chromatin;Chromatin Modeling;chromatin remodeling;Chromosomal Instability;Cytoskeleton;Development;DNA Damage;DNA Repair;Event;Fluorescence Recovery After Photobleaching;Fluorescence Resonance Energy Transfer;Funding;Genomic Instability;Goals;Hypersensitivity;Image;lung development;Lysosomes;Measures;Microfilaments;Microscope;Minor;Mitochondria;Mitotic;Morphology;Myosin ATPase;Nanostructures;Natural regeneration;nephrogenesis;nephron progenitor;new technology;Nuclear Protein;Optics;Pain;Pharmaceutical Preparations;Photobleaching;Phototoxicity;polymerization;Polymers;Productivity;Proteins;ratiometric;reproductive tract;Research;Resolution;Sampling;Signal Transduction;Site;Specimen;stem cells;Structure of paramesonephric duct;synaptogenesis;Synaptonemal Complex;System;temporal measurement;Therapeutic;Thick;trafficking;transcription factor PML;Ubiquitination;ultra high resolution;United States National Institutes of Health;Visualization

PROJECT_TITLE: Nikon CSU W1 SoRa Super Resolution Spinning Disk Confocal Microscope with Photo-Stimulation and Photo-Ablation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (30)]


PHR: Project Narrative This proposal requests funds to purchase hardware to meet the high-performance computing needs of users of the Structural Biology Core Facility at UT Health San Antonio. The requested GPU-equipped high-performance computing cluster will enable investigators to leverage state-of-the art software for all three major branches of structural biology including cryo-EM, X-ray crystallography, and NMR as well as artificial intelligence-based approaches to in silico modeling of multiprotein complex structures. Access to this equipment would otherwise be cost prohibitive and will accelerate the research efforts of a large number of NIH-funded investigators studying a wide range of biomedically-relevant problems with the goal of improving human health.

PI_NAMEs: OLSEN, SHAUN  (contact)

PROJECT_TERMS: Acceleration;Applications Grants;Architecture;cluster computing;cohort;Communities;Computer software;computerized data processing;Core Facility;cost;cost effective;Cryoelectron Microscopy;Data;data centers;Dedications;Development;drug discovery;Environment;Equipment;Fostering;Funding;Gold;Health;High Performance Computing;Human;improved;Individual;Infrastructure;instrumentation;Joints;Laboratories;Modeling;parallelization;petabyte;Postdoctoral Fellow;Process;Productivity;programs;protein complex;Recording of previous events;Research;Research Personnel;Resources;Roentgen Rays;shared memory;structural biology;System;Techniques;Time;tool;training opportunity;United States National Institutes of Health;Universities;X-Ray Crystallography

PROJECT_TITLE: A high performance computing cluster to support structural biology


NIH_SPENDING_CATS: Aging;Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Neurodegenerative;Neurosciences;Rare Diseases;Sarcopenia

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE Age-related declines in muscle mass and function are key contributors to frailty, which is a major public health problem that significantly reduces mobility, increases disability, hampers independence, and raises the risk of falls and injuries among the elderly. The lack of understanding of mechanisms of muscle wasting and weakness represents a critical barrier to progress toward the development of successful interventions for ameliorating physical frailty and thereby improving quality of life in old age. Through the elucidation of mechanisms that allow muscle motor units to expand their size to rescue muscle fibers destined to be lost due to denervation, this project will provide insights into processes and pathways that may be targeted for the development of rehabilitation interventions that exploit existing compensatory protective mechanisms to preserve muscle, prolong healthspan, and improve quality of life.

PI_NAMEs: BROOKS, SUSAN V (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acceleration;Adult;age effect;age-related muscle loss;Aging;Agonist;Amyotrophic Lateral Sclerosis;Animal Model;Atrophic;axon growth;axon guidance;axonal sprouting;Bioinformatics;CD44 gene;Cell Adhesion;Cell Count;Cell Proliferation;Cell Separation;Compensation;confocal imaging;Critical Pathways;Crush Injury;Cyclic AMP-Dependent Protein Kinases;Data;Denervation;Development;disability;Disease;Elderly;Enabling Factors;Event;experimental study;Failure;fall risk;familial amyotrophic lateral sclerosis;Fiber;fluorescence imaging;frailty;Genes;Genetic Models;Genomics;Goals;Health;healthspan;human old age (65+);Impairment;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Injury;insight;Intervention;Link;Measures;Mediating;Mobility decline;Modeling;Molecular;Motor;motor impairment;Motor Neurons;mouse model;multidisciplinary;Mus;Muscle;Muscle Fibers;muscle form;Muscle function;Muscle Weakness;Muscular Atrophy;Musculoskeletal;Nerve;Nerve Crush;nerve injury;nerve supply;neurogenesis;neuromuscular;Neuromuscular Junction;neuron loss;neuronal guidance;neutralizing antibody;old mice;older men;Operative Surgical Procedures;osteopontin;Pathway interactions;Pattern;Peripheral nerve injury;Physiological;Population;preservation;Preventive;PRKCA gene;Process;Proliferating;Property;protein expression;Public Health;Publishing;Quality of life;receptor;Regulation;Rehabilitation therapy;reinnervation;Reporting;response;Role;sarcopenia;Schwann Cells;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Skeletal Muscle;skeletal muscle wasting;Sorting;Structure;successful intervention;superoxide dismutase 1;Synapses;Testing;therapeutic target;Time;Up-Regulation;Validation;Wild Type Mouse;Work

PROJECT_TITLE: Preservation of muscle function through Schwann cell regulation of motor unit expansion

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]