NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Prevention;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

PHR: PROJECT NARRATIVE The current proposal aims to provide significant pre-clinical evidence that metformin, an FDA-approved Type II Diabetes drug, has therapeutic potential in reducing the risk of relapse in cocaine use disorder (CUD) while providing evidence for its mechanism of action in the nucleus accumbens core. Elucidating the pharmacological, behavioral, and neuronal impact of oral metformin dosing will contribute to the development of novel interventions for stimulant-related relapse behaviors. The long-term goal of this proposal is to yield significant justification for the repurposing of metformin as a treatment for CUD, a major public health concern.

PI_NAMEs: HERNANDEZ, EDITH  (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Abstinence;addiction;Adenosine Monophosphate;Adult women;Animal Model;Annual Reports;Antisense Oligonucleotides;Behavior;Behavioral;Behavioral Model;Biodistribution;Biological;Biosensor;blood-brain barrier crossing;Brain;brain tissue;Central Nervous System;Central Nervous System Agents;Cessation of life;Chronic;Clinical;Cocaine;cocaine cue;cocaine exposure;cocaine overdose;cocaine relapse;cocaine seeking;cocaine self-administration;Cocaine use disorder;Collaborations;cost;craving;Cues;Data;Development;Dose;Down-Regulation;drug craving;Drug Exposure;Drug Modelings;Drug usage;environmental stressor;Event;experience;experimental study;Extinction;FDA approved;Female;Fiber;Glucose;Glutamates;Goals;Homeostasis;human model;human subject;improved;in vivo;Intervention;knock-down;liquid chromatography mass spectrometry;male;Measures;Medical;Memory;Metformin;Methods;Microinjections;Minnesota;Modeling;Molecular;Mus;neuroadaptation;neuronal circuitry;Neurons;Neuropharmacology;neurotransmission;Noise;Non-Insulin-Dependent Diabetes Mellitus;novel;Nucleus Accumbens;Operative Surgical Procedures;Oral;Oral Administration;Oral Ingestion;Outcome;overdose risk;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Phosphorylation;Photometry;Physicians;Positioning Attribute;pre-clinical;Predisposition;Protein Kinase;Psychiatry;Public Health;Rattus;Recovery;Recurrent disease;Relapse;relapse risk;Reporting;Research;response;Rewards;Risk Reduction;Safety;Scientific Advances and Accomplishments;Scientist;Self Administration;sex;sex as a biological variable;Sex Differences;sex variable;Signal Transduction;Site;Stimulant;Surveys;Testing;Therapeutic;Therapeutic Effect;therapy development;Time;Training;Translating;translational model;transmission process;United States;Universities;Withdrawal;women patients;Work

PROJECT_TITLE: Repurposing Metformin as a Treatment for Cocaine Use Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F02A-W(20)]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness;Sleep Research;Social Determinants of Health

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative While experiences of early life adversity (ELA) have been shown to increase risk for depressive symptoms and the onset of major depressive disorder (MDD) during adolescence, the biobehavioral and neurobiological mechanisms underlying these associations are not well understood. Leveraging data from a multimethod longitudinal study, the proposed project investigates sleep disturbances as one pathway by which ELA is associated with altered frontolimbic development and increased risk for MDD across adolescence, a developmental period characterized by heightened sleep disturbances, ongoing brain development, and increased vulnerability to MDD onset. Findings from the proposed project will increase our understanding of the neurodevelopmental mechanisms by which ELA is related to increased risk for MDD and provide insight into sleep disturbances as a target of intervention during adolescence to ameliorate the effects of ELA.

PI_NAMEs: UY, JESSICA PHUONG (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: 10 year old;20 year old;Address;Adolescence;Adolescent;Affect;Affective;affective neuroscience;Age;Amygdaloid structure;Anterior;Area;Attenuated;attenuation;biobehavior;Biological;Brain;Brain region;career;Child;Childhood;Chronic;Cognitive;Critical Pathways;Data;data acquisition;Data Collection;depressive symptoms;Development;Diagnosis;disability;Dorsal;early experience;Early identification;early life adversity;early life stress;Ecological Change;Environment;Exhibits;experience;Experimental Designs;Exposure to;Family;Growth;Health;High School Student;Hippocampus;Hour;Incidence;Individual;insight;Institution;interest;Intervention;Lateral;life span;Link;Literature;Longitudinal Studies;Major Depressive Disorder;Mediating;Mediation;Mental Depression;Mental disorders;Methodology;Methods;Modeling;multimodal data;Nature;negative affect;neglect;neurobiological mechanism;Neurobiology;neurodevelopment;novel;Onset of illness;Participant;Pathway interactions;Population;Predictive Factor;Prefrontal Cortex;Prevalence;Prevention;Process;Psychopathology;psychosocial;Puberty;Recommendation;Recurrence;Regulation;Reporting;Research;Resources;Risk;Risk Factors;risk prediction;Severities;skills;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep quality;Stress;stress reactivity;Structure;Techniques;Time;Training;United States;Universities;white matter;young adult;Youth

PROJECT_TITLE: Effects of Early Life Stress and Sleep Disturbance on Frontolimbic Development and Risk for Depression Across Adolescence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-H(20)L]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Opioid Misuse and Addiction;Opioids;Patient Safety;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: CINCINNATI

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE This project is relevant to public health because patients with both opioid use disorder (OUD) and posttraumatic stress disorder (PTSD) are at high risk for dropping out of buprenorphine medication therapy and experiencing overdose. Our phased project will first examine how helpful patients with PTSD and OUD find a device that administers therapeutic electrical stimulation to their vagus and trigeminal nerves through the skin around their ears and then complete FDA pre-submission for using the device with this population more broadly. Finally, we will study how effective the device is for helping patients with PTSD and OUD stay in buprenorphine treatment by comparing the results of those who received therapeutic stimulation versus those who believed that they had but, in fact, did not.

PI_NAMEs: SPRUNGER, JOEL GREGORY (contact)

PROGRAM_OFFICER_NAME: AKLIN, WILL

PROJECT_TERMS: Acute;Address;Affective;Back;Buprenorphine;buprenorphine treatment;Caring;Clinic;Clinical;Clinical Trials;clinically significant;Communities;coping;craving;Data;design;Development;Devices;Diagnostic;distress tolerance;Double-Blind Method;Dropout;Drops;Ear;effective therapy;Electric Stimulation;Electric Stimulation Therapy;Endorphins;experience;Feasibility Studies;Feedback;Foundations;Heart Rate;high risk;improved;Individual;innovation;Inpatients;Intervention;Measures;Medical;medication for opioid use disorder;Methods;mortality risk;Motivation;multilevel analysis;negative affect;noninvasive brain stimulation;open label;opioid overdose;opioid use;opioid use disorder;opioid withdrawal;Outcome;Overdose;pain sensation;Participant;Patient Recruitments;Patient Self-Report;Patients;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;phase II trial;Population;portability;Post-Traumatic Stress Disorders;primary endpoint;primary outcome;Provider;Public Health;Quality of life;Randomized;randomized, clinical trials;recruit;reduce symptoms;Regulatory Pathway;Reporting;Research;Research Design;response;Risk;Sampling;secondary outcome;Serious Adverse Event;Severities;Skin;Sparrows;standard care;standard measure;substance use;Substance Use Disorder;Supervision;Symptoms;System;Techniques;Testing;Therapeutic;Time;time use;timeline;treatment comparison;Trigeminal nerve structure;Trigeminal System;vagus nerve stimulation;Vagus nerve structure;Visit;Withdrawal Symptom

PROJECT_TITLE: Improving Buprenorphine Retention with Transcutaneous Auricular Neurostimulation for Patients with Co-occurring Posttraumatic Stress Disorder and Opioid Use Disorder


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Palliative Care;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Responsibilities of caregivers of people living with dementia increase over time, and without adequate training and support American Indian caregivers experience adverse health consequences. This community-based study addresses caregiver concerns by enhancing the Savvy Caregiver Program with a peer component to improve caregiver mastery and reduce feelings of depression and isolation among American Indian caregivers of White Earth Nation in Minnesota. Our findings will promote knowledge translation and inform the development of peer- based interventions grounded in cultural values to improve quality of life and outcomes for American Indian dementia caregivers.

PI_NAMEs: LEWIS, JORDAN PAUL (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adverse event;Aging;Alzheimer's Disease;American Indian community;American Indian Population;American Indians;arm;behavior change;Buffers;caregiver education;caregiver interventions;Caregiver research;Caregiver support;Caregiver well-being;Caregivers;caregiving;Caring;Communities;community based participatory research;community engagement;community living;Control Groups;Coping Skills;cost effective;Country;cultural values;culturally appropriate intervention;Data;Dementia;Dementia caregivers;design;Development;Disease Management;Dissemination and Implementation;Education;Educational Curriculum;Educational Materials;Effectiveness;effectiveness evaluation;Elements;Empathy;Enrollment;Ensure;evidence base;Exercise;expectation;experience;Family Caregiver;Feeling;Future;Goals;Health;Health behavior;health care availability;Home;Hour;Hybrids;improved;Indigenous;indigenous community;Infrastructure;insight;interest;intergenerational;Intervention;Knowledge;knowledge translation;Learning;Literature;Lived experience;Measures;Mediating;Mediation;Medical;member;Memory;Mental Depression;Mentorship;Minnesota;Modeling;Outcome;Participant;peer;peer coaching;peer support;Personal Satisfaction;Persons;physical conditioning;Pilot Projects;Play;Preparation;Productivity;programs;Protocols documentation;prototype;psychoeducation;psychoeducational intervention;psychosocial;Quality of Care;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Resources;Role;Safety;Self Efficacy;skills;social;social cognitive theory;Social support;Stress;Structure;Support Groups;Testing;theories;Time;Training;Training and Education;transmission process;Uncertainty;uptake;White Earth;Work

PROJECT_TITLE: Enhancing American Indian Caregiver Mastery through a Savvy Caregiver Peer Program

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infertility;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Narrative: The goal of this research is to produce normal eggs from patient's skin cells to treat infertility. We will define fundamental biological questions regarding feasibility of separating chromosome pairs in diploid cells and deriving haploid oocytes.

PI_NAMEs: MITALIPOV, SHOUKHRAT  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Base Sequence;Biological;Cell Cycle;Cell division;Cell Nucleus;Cells;Characteristics;Chromatids;Chromatin;Chromosome Pairing;Chromosomes;Cytoplasm;daughter cell;Development;Diploid Cells;Diploidy;directed differentiation;Disease;DNA biosynthesis;DNA Double Strand Break;egg;Elderly;Embryo;Embryo Research;Embryo Transfer;embryonic stem cell;Epigenetic Process;Event;Fertilization;Frequencies;Future;G1 Arrest;Gametogenesis;Generations;Genetic;Genetic Recombination;Genetic Transcription;Genome;Germ Cells;Goals;Haploidy;Homologous Gene;Human;Hybrid Cells;imprint;In Vitro;Inbred Strains Mice;induced pluripotent stem cell;Infertility;infertility treatment;insight;Interphase;Mammals;Meiosis;Metaphase;mouse model;Mus;novel;offspring;Oocytes;Pathway interactions;Patients;Ploidies;Pre-implantation Embryo Development;premature;Primates;Process;Production;programs;reproductive;Research;Role;segregation;Skin;Somatic Cell;somatic cell nuclear transfer;sperm cell;success;Therapeutic;therapy development;Totipotency;Totipotent;Transplantation;Triploidy;zygote

PROJECT_TITLE: Reconstructing Somatic Chromosomes

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project narrative Neuroscientists use computational models of neurons and networks of neurons to gain insight into the nervous system in health and disease by testing hypothesized mechanisms and by making predictions about data that cannot be readily measured experimentally. Because of the increasing complexity of these models, there is an increasing need for the development and dissemination of methods to accelerate these simulations across multiple spatial scales. This project addresses those needs, building on the strengths of the widely used, open- source NEURON simulator.

PI_NAMEs: HINES, MICHAEL L;MCDOUGAL, ROBERT A. (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Acceleration;Address;Affect;application programming interface;base;Behavior;Biological;biophysical model;Biophysics;Brain;Cell model;Cells;cloud based;Code;Collaborations;Communities;Companions;Complex;computational neuroscience;Computer Models;Computing Methodologies;Confusion;Coupling;Cytoplasm;Data;Data Analyses;Data Sources;Dendrites;Development;Dimensions;Disease;Disparate;Documentation;Educational process of instructing;Educational Status;Electronic Mail;Environment;Event;experience;experimental study;extracellular;flexibility;Future;graduate student;Health;improved;Individual;insight;interoperability;Ion Channel;Language;Learning;Linux;Location;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Maps;Measures;Memory;Methods;Modeling;Modernization;Molecular;Morphology;multi-scale modeling;Nervous System;network models;neural;neural model;Neurons;Neurophysiology - biologic function;Neurosciences;novel;open source;Organism;Outcome;Paper;Persons;Physiological;preservation;programs;Property;Pythons;Recording of previous events;Reporting;repository;Research;Research Personnel;Resolution;Resources;response;Running;Shapes;simulation;Source;Specific qualifier value;Speed;Structure;Students;Study models;supercomputer;Synapses;Testing;Text;theories;Therapeutic;Tissues;tool;Training;undergraduate student;Update;Visualization software;web site;wide area network;Work;Writing

PROJECT_TITLE: Computer Methods for Physiological Problems

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Mental Health;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative Chronic pain and alcohol use disorders are highly comorbid conditions with a complex, bidirectional relationship. Relapse to alcohol use is associated with increased pain, but therapeutics to reduce relapse risk in the context of chronic pain are lacking. Experiments in this proposal will use a rodent model of chronic pain to investigate the role of discrete neural circuits in the regulation of alcohol relapse-related behavior in animals with chronic pain.

PI_NAMEs: BARKER, JACQUELINE M (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Acute Pain;Adult;Affective;Alcohol consumption;alcohol effect;alcohol exposure;alcohol relapse;alcohol reward;alcohol seeking behavior;alcohol use disorder;Alcohols;allodynia;Amygdaloid structure;Animals;Automobile Driving;Behavior;Behavioral;Chronic;chronic neuropathic pain;chronic pain;chronic painful condition;Cognitive;comorbidity;Complex;conditioned place preference;conditioning;Data;Development;Distress;Dose;Electrophysiology (science);Ethanol;Exhibits;expectation;experience;experimental study;Extinction;Female;Genetic;Glutamates;Heterogeneity;High Prevalence;Impairment;Implant;in vivo;Individual;inflammatory pain;injured;insight;Investigation;Link;Maintenance;male;Medial;Mediating;men;Modeling;multi-electrode arrays;Mus;Negative Reinforcements;nerve injury;neural;neural circuit;neurobehavioral;Neurobiology;Nucleus Accumbens;Output;Pain;Pain intensity;pain processing;pain reduction;Patients;persistent symptom;Persons;Positive Reinforcements;pre-clinical;Prefrontal Cortex;psychosocial;Psychosocial Stress;reduced alcohol use;Regulation;Relapse;relapse risk;Reporting;Research;Rewards;Risk;Rodent Model;Role;scaffold;spared nerve;Surgical Injuries;targeted treatment;Testing;Therapeutic;Training;Treatment Efficacy;Woman;Work

PROJECT_TITLE: Prelimbic cortex contribution to ethanol seeking in chronic neuropathic pain

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Opioids;Rehabilitation;Substance Misuse

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Alcohol consumption stimulates the release of endogenously-produced opioid peptides that influence the rewarding effects of this drug. With continued consumption and over time, the ability to stimulate the same level of response changes fundamentally, although it is not known if such changes include the production of novel peptides from the same family. Here we will apply the use of advanced analytical platforms and animal models of addiction behavior towards the discovery of new peptide sequences that may assist in the development of pharmacotherapeutics for treating individuals with Alcohol Use Disorder.

PI_NAMEs: NATIVIDAD, LUIS ALBERTO (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Abstinence;addiction;Address;Adherence;advanced analytics;Agonist;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol misuse;alcohol use disorder;Alcohols;Animal Model;antagonist;Area;Automobile Driving;Behavior;Behavioral;Behavioral Model;Binding;Brain;Chronic;Clinic;Clinical;clinical efficacy;Clinical Research;Cognition;Cognitive;cognitive function;cognitive performance;cognitive recovery;cognitive testing;Cognitive Therapy;Complex;Consumption;craving;Data;density;Dependence;desensitization;Development;druggable target;Elements;endogenous opioids;Enkephalins;Environment;Ethanol;Family;flexibility;Foundations;frontal lobe;Functional disorder;Goals;Human;Impairment;improved;in vivo;Individual;Infusion procedures;insight;Investigation;Knowledge;Laboratories;Leucine Enkephalin;Ligands;long term abstinence;Mass Spectrum Analysis;Medial;Mediating;Methionine Enkephalin;Microdialysis;Modeling;Molecular;Monitor;Motivation;Naltrexone;Neuropeptides;non-opioid analgesic;novel;Opioid;Opioid Antagonist;Opioid Peptide;Opioid Receptor;Pathology;Patients;Pattern;Peptides;Performance;Pharmaceutical Preparations;Pharmacy (field);Phosphorylation;Phosphorylation Site;Play;preclinical study;preference;Prefrontal Cortex;Prevention;Process;Production;proenkephalin;Property;protein aminoacid sequence;Protein Precursors;Proteome;Rattus;Receptor Signaling;Recovery;Relapse;Research;response;Rewards;Rodent;Role;Short-Term Memory;Signal Transduction;success;Symptoms;Time;treatment adherence;vapor;Work

PROJECT_TITLE: Investigation of non-canonical opioid signaling in the prefrontal cortex of alcohol-dependent rats


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Congenital Muscular Dystrophy;Congenital Structural Anomalies;Genetic Testing;Genetics;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Muscular Dystrophy;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: The goal of this project is to use cell-based high-throughput assays to reliably predict the consequences of genetic variants of unknown significance discovered in the course of genetic testing in a subset of muscular dystrophies caused by mutations in a set of alpha-dystroglycan glycosylating enzymes: FKTN, FKRP, POMT1, POMT2, and POMGNT1. We propose to use an integrated experimental and computational approach that combines multiple high-throughput assays of protein trafficking and function and machine-learning to generate pathogenicity predictions for all possible single-nucleotide variants in these dystroglycanopathy genes and then validate and disseminate our predictions with respect to disease risk and severity using extensive clinical data and primary tissue samples from patients with muscular dystrophy.

PI_NAMEs: HALLER, GABRIEL E (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: accurate diagnosis;Adult;Amino Acids;Archives;Benign;Biochemical;Biological;Biological Assay;Biology;biomedical referral center;Brain;Breathing;Caring;causal variant;Cell Adhesion;Cell surface;Cells;Cellular Assay;Cessation of life;Childhood;Classification;Clinical;Clinical Data;clinical translation;congenital muscular dystrophy;CRISPR screen;Data;Databases;Diagnosis;Diagnostic;Disease;disease-causing mutation;disorder risk;DNA;Dystroglycan;dystroglycanopathy;Enzymes;Eye;Fibroblasts;Fostering;fukutin;fukutin related protein;gene therapy;Genes;Genetic;Genetic Code;genetic disorder diagnosis;genetic information;genetic testing;genetic variant;Genetic Variation;glycosylation;Glycosyltransferase Gene;Goals;high throughput screening;Human;improved;In Vitro;in vitro Assay;Individual;International;Learning;Libraries;Limb-Girdle Muscular Dystrophies;Machine Learning;machine learning algorithm;Measures;Methods;Missense Mutation;Muscle;Muscular Atrophy;Muscular Dystrophies;Mutagenesis;mutant;Mutation;mutation screening;Myopathy;novel strategies;novel therapeutics;Nucleotides;online repository;Outcome;Pathogenicity;Patients;premature;prenatal;Property;protein function;protein O-mannose beta-1,2-N-acetylglucosaminyltransferase;protein transport;protein-O-mannosyltransferase 1;protein-O-mannosyltransferase 2;Proteins;Registries;Resolution;Resources;Saliva;Sampling;segregation;Severities;Severity of illness;Single Nucleotide Polymorphism;Skeletal Muscle;Specimen;Symptoms;Testing;Therapeutic;Time;Tissue Sample;tool;Uncertainty;Variant;variant of unknown significance;α-Dystroglycan

PROJECT_TITLE: Massively-parallel functional interrogation of genetic variation in CMD-associated alpha-dystroglycan glycosylating enzymes

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE Traumatic brain injury (TBI) imposes an enormous public health burden in the United States, affecting 2.8 million people yearly, comprising the leading cause of death in patients aged 1-44 years old, and causing a “silent epidemic” of persistent disabilities afflicting 5.3 million Americans and culminating in a $102bn yearly cost. However, as no targeted therapies exist for TBI, there is a critical need to uncover molecular mechanisms that could unlock the potential for effective cellular regeneration by NG2-glia, the largest population of regenerative cells in the adult brain, to aid in recovery from TBI. Using techniques in chronobiology, developmental biology, neurotrauma, and omics sciences, it is the goal of this proposal to identify the downstream effectors of the circadian clock that regulate NG2-glia regenerative potential to be able to identify the molecular pathways that could serve as future targets to enhance post-TBI cellular regeneration.

PI_NAMEs: DEAN, TERRY  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Adult;Affect;Affinity Chromatography;aged;American;ARNTL gene;Autopsy;bench to bedside;Binding;Brain;Brain Injuries;career;career development;Cause of Death;cell regeneration;cell type;Cells;Child;Chromatin;Chronic disability;Chronobiology;circadian;circadian biology;circadian pacemaker;Circadian Rhythms;clinically relevant;Code;Collaborations;conditional knockout;cost;Critical Care;CSPG4 gene;Data;Deoxyuridine;Dependence;Development;Development Plans;Developmental Biology;differential expression;disability;Disease;DNA Binding;DNA-Protein Interaction;Educational process of instructing;Epidemic;Evaluation;experience;Feedback;Foundations;Funding;Future;Gene Expression;Gene Proteins;Gene Targeting;Genes;Genetic Transcription;Goals;Head;Health;Health Sciences;Heterogeneity;Hospitals;Human;Immunohistochemistry;In Vitro;Injury;Institution;Laboratories;Maps;Measures;medical schools;Medicine;Mentors;Methods;Molecular;mouse model;Mus;Natural regeneration;Nervous System Trauma;Neuroglia;Neurosciences;Pathology;Pathway interactions;Patients;Pediatrics;Periodicity;Persons;Phase;Physicians;Population;Positioning Attribute;pre-clinical research;Process;professor;programs;Proliferating;Property;Proteins;Public Health;Publishing;regeneration following injury;regeneration potential;regenerative;regenerative cell;Regenerative Medicine;regenerative therapy;Reporting;Research;Research Personnel;response;Rest;Ribosomes;Role;Science;Scientist;skills;System;targeted treatment;TBI treatment;Techniques;Testing;Therapeutic;therapy development;Time;Tissues;Training;transcription factor;transcriptome sequencing;Transgenic Organisms;Translating;translatome;Traumatic Brain Injury;Traumatic Brain Injury recovery;United States;Universities;Washington;white matter;Writing

PROJECT_TITLE: Endogenous circadian clocks regulate NG2-glia regenerative potential

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Perturbation of sphingolipid metabolism, which is regulated by saposins and their precursor protein prosaposin (PSAP), has recently emerged as a critical risk factor for the onset and progression of neurodegenerative diseases. The goal of the proposed research is to determine how PSAP cleavage into saposins is regulated by lysosomal enzymes, progranulin, and age, and how this contributes to lysosomal function. Successful completion of these experiments will provide novel understanding of the causes and mechanisms underlying lipidome changes neurodegenerative disease and hopefully bring us one step closer to a cure.

PI_NAMEs: HODUL, MOLLY  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: acid sphingomyelinase;Address;Age;age related neurodegeneration;age-related disease;Aging;aging related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease related dementia;Autophagocytosis;Behavioral;Behavioral Assay;Binding;biological adaptation to stress;Biology;Brain;Caenorhabditis elegans;Cathepsins;Cell Aging;Cells;Cellular Stress;Clinical;Communication;Complex;Degenerative Disorder;Dementia;dementia risk;Diagnostic Procedure;Disease;Enzymes;Etiology;experimental study;frontier;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional disorder;Generations;Genetic;gerotherapeutic;Glycerol;Goals;Health;Homeostasis;Human;Human Cell Line;Imaging Techniques;Impairment;In Vitro;in vivo;innovation;Knowledge;life span;Link;Lipase;lipid metabolism;lipidome;lipidomics;Lipids;lysosomal proteins;Lysosomes;Machine Learning;Measures;Membrane;Metabolism;Modernization;Molecular;Molecular Medicine;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;Neurosciences;novel;novel diagnostics;novel therapeutics;Pathogenicity;Pathology;Pathway Analysis;Pathway interactions;Peptide Hydrolases;PGRN gene;Phenotype;Physiology;Play;Prevention strategy;Production;Progressive Disease;Protein Precursors;Proteins;Proteome;Protocols documentation;Recombinants;Regulation;Research;response;Risk Factors;Role;Saposins;sensor;Sphingolipids;System;Techniques;Testing;Therapeutic;trafficking;transcriptomics;Yin

PROJECT_TITLE: Investigating the regulation of lipid homeostasis and lysosomal function in neurodegenerative disease by prosaposin and progranulin in C. elegans


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LEEDS

ORG_NAME: NORTHAMPTON VA MEDICAL CENTER

ORG_STATE: MA

PHR: In 2014, Congress enacted the Veterans Access, Choice, and Accountability ACT (VACAA) to establish the Veterans Choice Program (VCP) and expand the availability of community care for eligible Veterans. VCP has grown by 138% since its inception to include more than half a million providers. This rapid growth has led to concerns within VA related to the adequacy of non-VA provider networks and a need to develop appropriate measures of network adequacy. In the context of these questions is also the need to better understand organizational decision-making processes regarding Community Care at the local level as these decisions affect which Veterans receive care within the VA or in the community. This service directed research proposal aims to develop standardized measures of network adequacy and examine VAMC characteristics associated with high rates of Community Care provision. Upon completion of this project, we will be poised to assist policymakers in decisions shaping community care standards for the VHA.

PI_NAMEs: MATTOCKS, KRISTIN M. (contact);MENGELING, MICHELLE ANN

PROJECT_TERMS: Access to Information;Accountability;Administrator;Affect;Amendment;Appointment;Area;care providers;Caring;Cessation of life;Characteristics;Communication;Communities;Communities That Care;Community Care Networks;community engagement;Community Healthcare;Community Networks;community partnership;Community Services;Congresses;Contracts;Country;Data;Decision Making;design;Development;Directories;Elements;Eligibility Determination;Enrollment;Ensure;Evaluation;Face;Federally Qualified Health Center;Geography;Grant;Health;health care quality;health care service;health plan;Health Services Accessibility;Healthcare;Healthcare Market;improved;Individual;innovation;Interview;Investigation;Marketing;Measures;Medical center;medical specialties;meetings;Methods;Organizational Decision Making;participant enrollment;Patients;Physicians;Policies;Policy Maker;preference;Primary Care;Privatization;Process;programs;Provider;provider networks;Qualitative Methods;Quality of Care;rapid growth;Recording of previous events;Research;Research Proposals;response;Services;Shapes;Standardization;standardize measure;Statutes and Laws;success;System;Time;United States Centers for Medicare and Medicaid Services;Variant;Veterans;Veterans Health Administration;Wait Time;Work

PROJECT_TITLE: Understanding Network Adequacy and Community Engagement in Veteran Care

STUDY_SECTION_NAME: Health Services Research[HSR0]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Mental Health;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Methadone Patient Access to Collaborative Treatment (MPACT) is a staff-level, trauma-informed practice change intervention for US opioid treatment programs (OTP) to increase treatment retention and decrease in-treatment overdose and patient- and staff-reported posttraumatic stress symptoms (PTSS). It is based on the theory that current OTP practice and culture likely contribute to treatment interruption and relapse rates of 30%-50% which, in turn, increase the risk of opioid overdoses. MPACT will be designed for immediate implementation and scalability; and includes four evidence-based components: 1) a 4-module CME/CEU-accredited trauma-informed psychoeducation training program for OTP staff, 2) a trauma navigation model for patients and staff, 3) clinic trauma-informed care (TIC) self-assessment, and 4) separate reflective supervisory structures for counselors/case managers and medical providers.

PI_NAMEs: MEYERSON, BETH  (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Accreditation;Address;Adopted;Adoption;Advocacy;Affect;Arizona;Belief;Binding;Buprenorphine;Caring;Case Manager;Clinic;community based research;Counseling;COVID-19;Data;design;Dose;Drug usage;effectiveness outcome;efficacy evaluation;empowerment;evidence base;experience;Exposure to;flexibility;Future;Harm Reduction;Health Personnel;Healthcare;Hepatitis C virus;high reward;high risk;Hybrids;implementation fidelity;implementation outcomes;improved;innovation;Interruption;Intervention;Intervention Trial;Life;Liquid substance;Maintenance;maltreatment;Measurement;Measures;Medical;member;Methadone;methadone patient;methadone treatment;Modeling;Occupations;opioid overdose;Opioid replacement therapy;opioid treatment program;opioid use disorder;Outcome;Overdose;Overdose reduction;patient oriented;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;pilot test;Policy Research;post-traumatic symptoms;Preparation;primary outcome;Process;Professional counselor;Provider;psychoeducation;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Regulation;Relapse;Reporting;Research;Research Personnel;response;retention rate;Risk;Rural;Sampling;Self Assessment;Self Care;Services;Site;Stigmatization;Structure;Substance Use Disorder;success;Surveys;telehealth;Testing;theories;Theory of Change;therapy design;Time;Training;Training Programs;Trauma;Trauma patient;treatment effect;treatment program;Treatment Protocols;Universities;Urine


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BERKELEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Age-related cognitive decline and Alzheimer's disease (AD) represent urgent biomedical and social problems that remain poorly understood and with no effective treatments. Major theories of causation of AD invokes deposition of proteins known as amyloid and tau, and disruption of the blood-brain barrier (BBB), but we do not understand what aspects of aging first “trigger” the disease process and the interaction between these separate potential culprits. In this project, we will use both mouse models of AD, as well as studies in older cognitively normal people, to explore the relationships between alterations in the BBB and amyloid and tau deposition in order to understand the mechanisms that may drive the initiation and progression of AD.

PI_NAMEs: JAGUST, WILLIAM J. (contact);KAUFER, DANIELA

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Age-associated memory impairment;Aging;aging brain;Albumins;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid;Area;Astrocytes;Biological;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;blood-brain barrier permeabilization;Brain;cerebrovascular;Characteristics;Cognitive;cognitive change;cognitive function;contrast enhanced;Contrast Media;Data;Deposition;Development;Discipline of Nuclear Medicine;Disease;effective therapy;Episodic memory;Etiology;Event;Extravasation;Feedback;Genetic;Hippocampus;Histopathology;Human;human data;Human Volunteers;imaging approach;Immunohistochemistry;Impaired cognition;Impairment;improved;Individual;Inflammatory Response;Infusion procedures;Intervention;Intuition;Link;loss of function;Magnetic Resonance Imaging;Maps;Measurement;Measures;medial temporal lobe;Mediating;Memory;mild cognitive impairment;Modeling;Molecular;molecular marker;molecular size;mouse model;Mus;neural;Neurologic;Neuronal Dysfunction;Neurophysiology - biologic function;novel;old mice;Older Population;Pathogenesis;Pathologic;Pathology;Pathway interactions;Penetration;Persons;pharmacologic;Plasma Proteins;Positron-Emission Tomography;pre-clinical;Process;protein aggregation;Proteins;regional difference;Rodent;Scanning;Serum Albumin;Serum Proteins;Signal Transduction;Social Problems;tau aggregation;tau mutation;tau Proteins;temporal measurement;Testing;theories;Thick;Thinness;Time;Transforming Growth Factor beta;Transgenic Mice;Translating;translational model;transmission process;Vascular Diseases

PROJECT_TITLE: The blood-brain barrier and Alzheimer pathology

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative The endogenous ADAR has multifaceted biological functions and is an emerging target for versatile gene therapy and immunotherapy. Here, we propose to screen and engineer novel nucleic acid tools to profile endogenous ADAR in vivo, promote ADAR modulatory efficacy, and test the efficacy to harness endogenous ADAR for disease therapy in mouse models. These studies may establish novel tools and their engineering principles to facilitate ADAR biology discovery and advance ADAR-based therapy. 1

PI_NAMEs: ZHU, GUIZHI  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acetylgalactosamine;ADAR1;Address;Adenosine;Agonist;Albumins;aptamer;Biological;Biological Process;biological systems;Biology;bioluminescence imaging;Cells;Chimera organism;Clinical;Cyclic GMP;design;Disease;DNA;Drug Kinetics;dsRNA adenosine deaminase;efficacy testing;Engineering;Environment;factor V Leiden;gene therapy;genome editor;Guide RNA;Guidelines;Human;Immunotherapy;improved;in vivo;Individual;Inosine;Interferon Type I;Ligands;lipid nanoparticle;Luciferases;Mediating;Medicine;Melanoma;Messenger RNA;Metastatic Melanoma;Molecular;mouse model;mRNA delivery;Mutation;nanoparticle;nanoreporter;neoplastic cell;novel;nucleic acid delivery;nucleic acid-based therapeutics;Nucleic Acids;Oligonucleotides;Outcome;Pathogenicity;Peptides;pilot test;Reporter;RNA;RNA Binding;RNA Editing;Safety;scaffold;Shapes;Small Interfering RNA;spatiotemporal;stoichiometry;success;targeted delivery;Testing;theranostics;therapeutic RNA;Thrombophilia;Time;Tissues;tool;trafficking;Treatment Efficacy

PROJECT_TITLE: Nucleic acid modulators and theranostics for ADAR

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence;Neurosciences;Nutrition;Obesity

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative This high-risk, high-reward proposal will test whether we can use novel machine-learning methods to design drug mixtures that jointly activate or inhibit, respectively, the activity of neurons that increase or decrease satiety, while sparing off-target neurons types to reduce side effects. We will optimize this approach using cutting-edge imaging of 1000s of hypothalamic neurons that control energy balance, and then test customized optimized mixtures in mouse models of obesity. In future, we hope to use this approach to guide ongoing polypharmacy approaches to treating diabetes and obesity in humans.

PI_NAMEs: ANDERMANN, MARK L (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: 3-Dimensional;Affect;Animal Model;Area;awake;Body Weight;Body Weight decreased;Brain;Calcium;cell type;Chemicals;Clinical Research;combinatorial;Diabetes Mellitus;diet-induced obesity;Drug Design;Drug Targeting;Eating;energy balance;feeding;Feeding behaviors;Future;genetic approach;Genetic Transcription;GLP-I receptor;high dimensionality;High Fat Diet;high reward;high risk;Human;Hypothalamic structure;Image;Ligands;machine learning algorithm;machine learning method;Melanocortin 4 Receptor;Molecular;mouse model;Mus;Nausea and Vomiting;neural;Neurons;neuroregulation;novel;novel therapeutics;Obese Mice;Obesity;optogenetics;paraventricular nucleus;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Polypharmacy;receptor;receptor expression;reduced food intake;Regulation;Satiation;side effect;single cell sequencing;Slice;Structure of nucleus infundibularis hypothalami;Testing;Thinness;Time;tool;transcriptomics;two-photon

PROJECT_TITLE: High-dimensional chemical targeting of multiple neuron types to regulate energy balance

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-S (M3)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Immunotherapy;Patient Safety;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE The proposed Data Coordinating Center (DCC) will support all activities of the Blood and Marrow Transplant Clinical Trials Network, using the extensive expertise of its investigators in clinical and translational research, biostatistics, transplantation, and cellular therapies. The DCC will take advantage of collaborations with other organizations and initiatives to maximize efficiency and trial participation. The goal is to facilitate trials that pro- vide definitive answers to important clinical questions that will lead to changes in practice that increase survival and enhance quality of life for patients with serious malignant and non-malignant blood diseases.

PI_NAMEs: DEVINE, STEVEN M.;HOROWITZ, MARY MARESCA (contact);LOGAN, BRENT R;MENDIZABAL, ADAM M.

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Address;Adherence;Administrative Coordination;Adoptive Cell Transfers;Advisory Committees;Advocacy;Advocate;Aftercare;Allogenic;Autologous;biobank;Biometry;Blood;Bone Marrow Transplantation;career;Caregivers;Cell Therapy;Cells;Clinical;clinical center;Clinical Research;Clinical Trials;Clinical Trials Network;clinically relevant;Collaborations;Communities;cost;curative treatments;Data;Data Analyses;Data Coordinating Center;data management;Data Management Resources;data quality;Databases;demographics;design;Development;Disease;disorder prevention;Effectiveness;effectiveness clinical trial;Ensure;Ethnic Population;Evaluation;experience;Face;Fostering;Funding;Funding Opportunities;gene therapy;genetically modified cells;Geography;Goals;graft vs host disease;Hematological Disease;Hematopoietic Stem Cell Transplantation;improved;industry partner;Information Dissemination;Infrastructure;innovation;Institutional Review Boards;international center;Intervention;Investigational New Drug Application;Laboratories;Late Effects;Leadership;Logistics;Longterm Follow-up;Malignant - descriptor;Manuscripts;Marrow;medical schools;meetings;Mentorship;Methods;mid-career faculty;Modality;Monitor;National Cancer Institute;National Clinical Trials Network;National Heart, Lung, and Blood Institute;next generation;Non-Malignant;novel;Paper;Participant;Patient Care;patient engagement;Patient Outcomes Assessments;Patients;Peer Review;Performance;Pharmacy facility;Procedures;Process;Productivity;programs;prophylactic;prospective;protocol development;Protocols documentation;Publications;quality assurance;Quality of life;racial population;repository;Research;Research Design;Research Personnel;Resources;Risk;Role;Safety;Sample Size;Secure;Sickle Cell Anemia;Site;socioeconomics;Specimen;success;support network;System;Therapeutic;Therapy Clinical Trials;Therapy trial;Training;Translational Research;Transplantation Conditioning;transplantation therapy;treatment duration;Treatment-related toxicity;Wisconsin

PROJECT_TITLE: Blood and Marrow Transplant Clinical Trials Network DCC- The Medical College of Wisconsin, Inc.

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (M2)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: KANSAS CITY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PI_NAMEs: BARNES, RYAN P (contact)

PROGRAM_OFFICER_NAME: HEACOCK, MICHELLE

PROJECT_TERMS: Address;adduct;Aging;Aspergillus Nuclease S1;base;Base Excision Repairs;Binding;Biochemical;Biochemistry;Biological;biological adaptation to stress;Bypass;cancer cell;cancer predisposition;Cell Aging;Cell Death;Cell Line;cell transformation;Cells;Chimeric Proteins;Chromatin;chromophore;Chromosome Fragile Sites;Disease;DNA;DNA analysis;DNA biosynthesis;DNA Damage;DNA fiber assay;DNA lesion;DNA photoproducts;DNA Replication Factor;DNA replication fork;DNA Sequence;DNA-Directed DNA Polymerase;Dyes;Environment;experience;experimental study;FANCD2 protein;Genome;genome sequencing;Genome Stability;genome-wide;Genomic DNA;Genomic Instability;Genomics;Guanine;Half-Life;Histone H2B;Histones;Human;human DNA damage;Human Genome;Hydrogen Peroxide;In Vitro;Inflammation;Instruction;irradiation;Knock-out;Knowledge;Lesion;Light;Link;Lipids;macroH2A histone;Malignant Neoplasms;Metabolism;Methods;micronucleus;Mitosis;Mitotic;Mutagenesis;mutant;Mutate;Mutation;novel;Nuclear;OGG1 gene;Outcome;Oxidants;oxidative DNA damage;Oxidative Stress;Pathway interactions;Peptides;Photosensitizing Agents;Physiological;pleiotropism;Pollution;Polymerase;prevent;Production;Proteins;Publishing;Pyrimidine Dimers;Reaction;Reactive Oxygen Species;Regulation;repaired;replication stress;Reporter;response;Role;senescence;Single-Stranded DNA;Singlet Oxygen;Site;Skin Carcinogenesis;Smoking;solar radiation;Source;Specificity;Stress;Syndrome;System;telomere;Telomere-Binding Proteins;Telomeric Repeat Binding Protein 1;TERF1 gene;tool;Transfection;Ultraviolet Rays;UVA induced;whole genome

PROJECT_TITLE: Investigating the Cellular Impact of 8-oxo-Guanine on DNA Replication and Genome Stability

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Networking and Information Technology R&D (NITRD)

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative This project will develop new computational methods to analyze data from in situ spatial transcriptomics, which measures gene expression profiles in a spatial context. The proposed methods aim to enhance the analysis of in situ data, yielding more reliable cell boundaries, cell type annotations, and characterizations of the cellular microenvironment. These methods are anticipated to offer new biological insights into cell senescence and the tumor microenvironment, contributing to a deeper understanding of complex human diseases.

PI_NAMEs: JI, ZHICHENG  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Architecture;Bar Codes;Benchmarking;Biological;Cell Aging;Cell Communication;Cell Density;cell type;Cells;Cellular Morphology;Complex;computational suite;computerized tools;Computing Methodologies;Data;Data Set;Development;dimension reduction;Disease;flexibility;Gene Expression;Gene Expression Profile;Growth;human disease;Image;In Situ;Individual;insight;Learning;Location;Manuals;Measures;Methods;Microdissection;Performance;Resolution;RNA;segmentation algorithm;single-cell RNA sequencing;Spatial Distribution;Technology;Testing;Tissues;Transcript;transcriptomics;tumor microenvironment

PROJECT_TITLE: Computational methods for in situ spatial transcriptomics

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pain Research;Palliative Care;Social Determinants of Health;Telehealth

PHR: Project Narrative Pain, fatigue, and distress are highly prevalent, co-occurring, and interfering symptoms in patients with advanced cancer. Our team will test a brief telehealth-delivered psychosocial intervention that aims to decrease symptom interference and improve quality of life in patients receiving care in medically underserved areas. Our patient-centered approach will lay the foundation for future symptom management interventions, toward the goal of reducing suffering in those facing life- threatening illness.

PI_NAMEs: WINGER, JOSEPH GILES (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: advanced breast cancer;Advanced Malignant Neoplasm;Area;associated symptom;Breast;cancer care;Caring;Clinic;Cognitive Therapy;Colorectal;Data;Data Collection;design;Distress;efficacy evaluation;efficacy testing;efficacy trial;end of life;Equipment and supply inventories;experience;Family;Fatigue;Foundations;Future;future implementation;Goals;Home;implementation efforts;improved;insight;Intervention;Journals;Life;Lung;Maintenance;Malignant Neoplasms;Manuals;Medical;Medical center;Medically Underserved Area;Meta-Analysis;Methods;mindfulness;Modeling;multidisciplinary;Oncology;Outcome;Pain;Pain management;Palliative Care;Participant;Patient Care;patient oriented;Patient Outcomes Assessments;Patients;persistent symptom;Persons;Phase;pilot trial;Positioning Attribute;post intervention;primary endpoint;primary outcome;process evaluation;Prognosis;Prostate;Protocols documentation;Provider;Psychiatric Social Work;psychologic;psychosocial;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;reduce symptoms;remediation;Reporting;secondary outcome;Self Efficacy;Severities;side effect;skills;Supportive care;symptom management;Symptoms;telehealth;Telephone;Testing;therapy design;Time;Training;treatment effect;United States National Institutes of Health;videoconference;Videoconferencing;Work

PROJECT_TITLE: Engage: A Randomized Controlled Trial Testing the Efficacy of a Telehealth-Delivered Psychosocial Intervention to Decrease Symptom Interference in Patients with Advanced Cancer

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: JACKSONVILLE

ORG_NAME: UNIVERSITY OF NORTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative Muscle mass and strength change in response to a range of physiological and pathophysiological conditions, including neurodegenerative diseases, cancer, diabetes, neuromuscular disorders, and aging. Dual-specificity phosphatase 4 (Dusp4) has been found to be upregulated in response to neurogenic atrophy, but its role in the complex molecular events that modulate muscle mass remains unknown. This study will investigate the functional role of Dusp4 in skeletal muscle and identify the in vivo substrates targeted for dephosphorylation by Dusp4. This study will advance our understanding of the molecular mechanisms of muscle wasting and could lead to the identification of new therapeutic targets for the treatment of skeletal muscle atrophy.

PI_NAMEs: WADDELL, DAVID SCOTT (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Address;Aging;Amaze;Animals;Area;Atrophic;Attenuated;attenuation;Autophagocytosis;Cell Physiology;Complement;Complex;Cues;Degradation Pathway;Denervation;Development;Diabetes Mellitus;differential expression;Electroporation;Equilibrium;Event;Failure;Fiber;Gene Expression Profiling;Genes;Growth;Growth Factor;Hormones;Hypertrophy;Image;in vivo;Investigation;knock-down;Knockout Mice;Maintenance;Malignant Neoplasms;MAP Kinase Modules;MAP Kinase Signaling Pathways;MAPKinase Signaling Pathway;Measurement;Measures;mechanical load;Mediating;Microarray Analysis;Mitogen-Activated Protein Kinases;Molecular;multicatalytic endopeptidase complex;Mus;Muscle;Muscle Cells;muscle form;muscle hypertrophy;muscle strength;Muscular Atrophy;Myocardium;nerve transection;neural;Neurodegenerative Disorders;Neuromuscular Diseases;new therapeutic target;novel;Nutritional status;Outcome;overexpression;Pathway interactions;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;Plasmids;Play;Process;protein biomarkers;Protein Biosynthesis;protein degradation;Protein Dephosphorylation;Regulation;Research Proposals;Research Support;response;RNA Interference;Role;sciatic nerve;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;Specificity;System;Testing;Time;Ubiquitin;ubiquitin-protein ligase;Up-Regulation;Validation;virtual;wasting;Weight;Work

PROJECT_TITLE: The Functional Role of Dusp4 in Skeletal Muscle

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (SF)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;HIV/AIDS;Mental Health;Mental Illness;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: PROJECT NARRITIVE There is a global mental health crisis that is particularly problematic in the context of HIV in high impact settings where there is low reach of evidenced based mental health treatments. Based on our successful prior efficacy and effectiveness work with cognitive-behavioral therapy for adherence and depression (CBT-AD) in HIV, the current study is designed to identify replicable implementation strategies to enhance the reach of depression / adherence treatment in people living with HIV in S. Africa. If successful, the model can inform policy, funding decisions for HIV treatment delivery, and be extended to other low-resource settings for HIV and, potentially, other integrated medical/mental health settings and contexts.

PI_NAMEs: JOSKA, JOHN ANTON;O'CLEIRIGH, CONALL MICHAEL;SAFREN, STEVEN A (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Address;Adherence;Adoption;Advisory Committees;Africa;African;arm;Articulation;Books;Caring;Characteristics;Cities;Clinic;Clinical;Cognitive Therapy;Communities;community partnership;comorbid depression;Consolidated Framework for Implementation Research;cost effective;Data;Depression screen;design;Disease remission;Education;Effectiveness;effectiveness outcome;effectiveness study;effectiveness/implementation study;evidence base;Evidence based treatment;Funding;global health;Goals;Health Priorities;HIV;Hybrids;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Intervention;intervention delivery;Job Description;Link;Logic;Maintenance;Manuals;Maps;Medical;Mental Depression;Mental Health;Modeling;Monitor;Nurses;Outcome;Patients;Persons;Pharmaceutical Preparations;Policies;primary outcome;prospective;Psychiatrist;Psychologist;Public Health;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Resource-limited setting;Resources;response;Role;scale up;screening;Self Efficacy;Site;social stigma;South Africa;Supervision;Symptoms;Testing;therapy adherence;Trainers Training;Training;treatment adherence;uptake;Viral;Work

PROJECT_TITLE: Implementing depression and adherence treatment in S. Africa HIV care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-A (03)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative There are no cures available for neurodegenerative diseases including Dementia with Lewy Bodies, Parkinson’s disease, and Parkinson’s disease-dementia. These diseases are characterized by accumulation of protein aggregates. Our proposal includes methods to test the hypothesis that simultaneously improving protein folding, trafficking, and lysosomal clearance will synergistically improve phenotypes in cultures and mice.

PI_NAMEs: MAZZULLI, JOSEPH R (contact)

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: age group;age related neurodegeneration;alpha synuclein;Alzheimer's Disease;Binding;Biological Assay;Biological Markers;Blood;Brain;Classification;Clinical;Cognition;Cognitive;cognitive function;combinatorial;Combined Modality Therapy;Dementia;Dementia with Lewy Bodies;Development;Disease;dopaminergic neuron;dosage;Dose;Drug Combinations;early onset;Endoplasmic Reticulum;Enhancers;Failure;FDA approved;Foundations;Functional disorder;Future;Genetic;genetic risk factor;Genetic study;genome wide association study;genomic locus;glucosylceramidase;Glycosphingolipids;Goals;Golgi Apparatus;Histologic;human induced pluripotent stem cells;Hydrolase;improved;In Vitro;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Lead;Link;loss of function mutation;Lysosomal Function Induction;Lysosomes;Measures;Memory;Memory impairment;Methods;Modeling;Molecular Chaperones;Motor;mouse model;Mus;Mutant Strains Mice;Mutation;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;neurotoxicity;Odds Ratio;Parkinson Disease;Parkinson's Dementia;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Play;protein aggregation;protein folding;protein transport;Proteins;proteostasis;Quality Control;Risk;safety assessment;small molecule;SNAP receptor;SNCA gene;Stress;Substantia nigra structure;Symptoms;synucleinopathy;tau aggregation;Testing;Therapeutic;Therapeutic Effect;trafficking;treatment duration;Variant;Work

PROJECT_TITLE: Synergistic Enhancement of ER proteostasis, trafficking, and lysosomes as treatments for Dementia with Lewy bodies and Parkinson’s disease-dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-M (19)]


NIH_SPENDING_CATS: Aging;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE Maintaining muscular strength into old age is essential for independence, safety and daily activities; therefore, understanding contributors which lead to the progression of muscle fibrosis in aging will provide novel therapeutic strategies to delay or prevent sarcopenia. I have identified fibro/adipogenic progenitors (FAPs) as novel contributors to aged muscle fibrosis but the cellular and molecular events that lead to this are unclear. The goal of this proposal is to investigate FAPs through sarcopenia development to elucidate therapeutic approaches which leverage FAP metabolism to delay or prevent fibrosis and weakness associated with sarcopenia.

PI_NAMEs: LEE, DAVID E. (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: age related;age related decline;age-related muscle weakness;Aging;Area;Basic Science;Bioenergetics;Bioinformatics;Biology;career;career development;Caring;Cellular biology;Cellular Metabolic Process;cellular targeting;combat;Communication;Data;data acquisition;Data Analyses;data reduction;Data Set;Dedications;Development;Disease;Duchenne muscular dystrophy;economic cost;economic impact;effective therapy;Elderly;Equipment;Event;experimental study;fibrogenesis;Fibrosis;Frequencies;functional independence;Genetic;genetic manipulation;Glycolysis;Goals;Health;Health care facility;healthcare burden;Home;Hospitalization;human old age (65+);improved;In Vitro;in vivo;in vivo Model;Individual;Informatics;Injury;insight;Knowledge;life span;liquid chromatography mass spectrometry;Long-Term Care;Mass Spectrum Analysis;Mentored Research Scientist Development Award;Mentors;Mentorship;Metabolic;Metabolism;metabolomics;Mobility decline;Modeling;Molecular;Muscle;muscle aging;Muscle Cells;Muscle Weakness;Nature;novel;novel therapeutic intervention;older adult;Pathway interactions;Personal Satisfaction;Phenotype;Physiology;Positioning Attribute;prevent;progenitor;programs;Publishing;Research;Risk;Safety;sarcopenia;Science;Skeletal Muscle;social;socioeconomics;Statistical Data Interpretation;stem cell biology;stem cell differentiation;stem cells;success;Testing;Therapeutic;therapy development;Time;Training;transcriptome sequencing;translational therapeutics;treatment strategy;WNT Signaling Pathway

PROJECT_TITLE: Fibro/Adipogenic Progenitor Metabolic Reprogramming for Age-Related Muscle Fibrosis

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Microbiome

ORG_CITY: KNOXVILLE

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: PROJECT NARRATIVE Animals host complex communities of microbes that are part of the proper functioning of our bodies, and control of the microbiome by the immune system is critical for host health. This project will study how beneficial microbes and animal immune systems coevolve. By seeking this basic understanding of the evolutionary dynamics governing the microbiome, this research is relevant to the NIH’s mission to develop fundamental knowledge of living systems.

PI_NAMEs: PARKER, BENJAMIN JAMES (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Animal Model;Animals;Aphids;asexual;bacterial genetics;Bacterial Infections;bacteriome;beneficial microorganism;Biological Models;combat;Complex;Data;density;Disease;dysbiosis;Ecosystem;Enterobacteriaceae;forward genetics;Foundations;Future;Genes;Genetic Variation;Health;host microbiome;Human;Immune system;Immunity;Immunologics;Immunology;innovation;Insecta;insight;Knowledge;Link;Microbe;microbial;microbial community;microbiome;Mission;Modeling;Molecular Evolution;Natural Selections;Organism;Parasites;pathogen;Pattern;Phagocytes;Pisum sativum;Population;programs;Research;Resistance;Role;Shapes;symbiont;Techniques;Testing;trait;transcriptome sequencing;United States National Institutes of Health;Variant;Virulence;Work

PROJECT_TITLE: Understanding host-microbiome coevolution and genetic variation in immunity using an insect model system


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Nutrition;Physical Activity;Prevention;Sarcopenia;Social Determinants of Health

ORG_STATE: CA

PHR: Project Narrative Sarcopenia is a condition that causes a loss of muscle mass and function, which can greatly affect the quality of life and overall health outcomes of those with advanced lung disease. The built environment, which refers to the physical surroundings of individuals, is an important factor in the development and progression of sarcopenia, but it is often overlooked in research. Our proposal aims to investigate how the built environment is associated with sarcopenia and identify any barriers and facilitators in accessing exercise spaces and nutritional support.

PI_NAMEs: SINGER, JONATHAN PAUL (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acceleration;Acute;Address;Affect;Age;age related changes;built environment;burden of illness;Chronic;Clinical;community-level factor;Data;Development;digital;digital intervention;digital solutions;Education;Elements;environmental intervention;Environmental Risk Factor;Epidemiology;Exercise;exercise capacity;exercise program;Face;Food;food insecurity;Future;Goals;good diet;Grant;Green space;Health;Health behavior;Health Food;health related quality of life;Human;Hypoxia;Impairment;implementation strategy;Improve Access;Individual;Infrastructure;innovation;Intervention;Literature;Lung Diseases;Lung Transplantation;Malnutrition;Methods;Modeling;modifiable risk;Morbidity - disease rate;mortality;muscle form;Muscle function;muscle strength;Muscular Atrophy;Neighborhoods;novel;nutrition;Nutritional;Nutritional Support;older adult;older patient;Outcome;patient-level barriers;Patients;Physical activity;Physical environment;physical inactivity;Physiology;Play;Population;Prevalence;Prevention;programs;pulmonary function;Qualitative Methods;Quality of life;Reduce health disparities;Research;Research Proposals;Risk;Risk Factors;Role;sarcopenia;Shapes;skeletal muscle wasting;social;Social Concepts;Social Environment;social health determinants;Social support;Socioeconomic Status;systemic inflammatory response;Therapeutic Intervention

PROJECT_TITLE: The Built Environment and Sarcopenia in Patients with Advanced Lung Disease


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: Columbus

ORG_DEPT: GENETICS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Cellular defense protects individual cell against infection across all three domains of life. This proposal focuses on a new group of host immune proteins - the Guanylate Binding Protein-Like (GBPL) GTPases - in plant immunity. By employing cutting-edge techniques and interdisciplinary approaches, our efforts have the potential to unveil novel host defense mechanisms and should have broad implications for the development of innovative strategies for controlling infectious diseases in both plants and animals.

PI_NAMEs: HUANG, SHUAI  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;Animals;Arabidopsis;Binding Proteins;Biochemistry;Biological;Cells;Communicable Diseases;Cues;defense response;Development;Enzymes;Gene Expression;Genetic;Goals;Guanosine Triphosphate Phosphohydrolases;guanylate;Homeostasis;Host Defense;Host Defense Mechanism;Human;Image;Immune;Immune response;Immunity;Immunologic Surveillance;in vivo;Individual;Infection;innovation;insight;interdisciplinary approach;Life;member;Molecular;Mouse-ear Cress;Mutagenesis;novel;Organelles;Organism;pathogen;Pathway interactions;Phase;Physical condensation;Physiological;Plant Model;Plants;Process;Protein Family;Proteins;Proteomics;reconstitution;Research;Role;sensor;Structural Models;System;Techniques;Testing

PROJECT_TITLE: Immune control by GBPL proteins in Arabidopsis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: LAKE FOREST

ORG_NAME: LAKE FOREST COLLEGE

PHR: Public Health Relevance (Narrative): Infectious lung diseases carry devastating personal and economic costs, and as one of the world's most deadly infectious diseases, tuberculosis and its causative bacterium, Mycobacterium tuberculosis, remains a persistent and costly threat to public health. I have developed a research platform to investigate mycobacterial susceptibility and resistance genes, connecting findings from the molecular to organismal levels. In this research proposal, I seek to identify the molecular function of the mycobacterial protein and potential drug target, BrkB (aka Rv2707 in M. tuberculosis), and characterize how it protects bacteria from the host.

PI_NAMEs: CONRAD, WILLIAM HENRY (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Adult;Antibiotic Resistance;Antibiotics;Antitubercular Agents;Attenuated;attenuation;Bacteria;Bacterial Genes;Basic Science;Biochemical;Biochemistry;Biology;Biophysics;Bordetella;Bordetella pertussis;cell growth;Cells;Cellular biology;chemotherapy;Collaborations;Communicable Diseases;Complement;cost;COVID-19 pandemic;critical period;Culture Media;Defect;Diffusion;Drug Targeting;druggable target;economic cost;Electrophysiology (science);empowerment;Environment;Escherichia coli;experience;extracellular;Extracellular Space;Fertilization;Fluorescence;forward genetics;Foundations;Funding;Genes;Genetic;Genus Mycobacterium;Goals;Grant;Granuloma;Growth;Histologic;Homeostasis;Host Defense;Host resistance;Human;In Vitro;in vivo;Infection;Infectious Lung Disorder;inhibitor;Innate Immune System;Ion Channel;Ions;Label;Larva;Lysosomes;Macrophage;Measures;Mediating;Metabolism;Microbiology;Microscopy;model organism;Modeling;Molecular;mortality;Mus;mutant;Mutation;mycobacterial;Mycobacterium marinum;Mycobacterium smegmatis;Mycobacterium tuberculosis;Necrosis;new therapeutic target;novel;Nutrient;Optics;Organism;Orthologous Gene;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pertussis;Phagosomes;Positioning Attribute;Predisposition;Proteins;Protocols documentation;Public Health;public health relevance;Recombinants;Research;Research Proposals;Resistance;resistance factors;resistance gene;reverse genetics;Role;Students;Susceptibility Gene;System;Testing;therapeutic target;Time;tool;Transgenic Organisms;Transmembrane Domain;transmission process;Tuberculosis;tuberculosis treatment;undergraduate research;undergraduate student;Virulence;Virulence Factors;Visualization;Work;World Health Organization;Zebrafish

PROJECT_TITLE: Characterizing the requirement of the mycobacterial BrkB ortholog in TB pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SPJ-D (M1)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: Boulder

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Successful completion of this pilot project will establish a framework for defining the functions and mechanisms of EV-dependent RNA transfer in metabolism and metabolic diseases. Furthermore, this work will facilitate the engineering of EV-based vehicles to selectively deliver therapeutics to target tissues for the treatment of these diseases.

PI_NAMEs: SHEN, JINGSHI  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Adipocytes;Adipose tissue;Amino Acids;Binding;Biochemical;Biological Assay;Biological Process;candidate identification;Cell Line;Cell membrane;cell type;Cells;Chimeric Proteins;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR library;CRISPR screen;Cytosol;Development;Disease;Encapsulated;Endosomes;Engineering;Exclusion;exosome;Experimental Genetics;extracellular vesicles;Gene Expression;Genes;Genetic;genetic approach;Genetic Screening;Genetic study;Glucagon;head involution defective protein;Hepatocyte;Hormones;Human;human induced pluripotent stem cells;Impairment;Individual;insight;Insulin;Insulin Resistance;Knowledge;Libraries;Link;Liver;mammalian genome;Mediating;Mediator;Metabolic;Metabolic Diseases;Metabolism;MicroRNAs;microvesicles;Monitor;Multivesicular Body;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;novel therapeutics;Open Reading Frames;particle;Pathogenesis;Physiology;Pilot Projects;Play;Protein Databases;Protein Secretion;Proteins;receptor;reconstitution;Research;response;RNA;RNA delivery;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Surface;Testing;Text;Therapeutic;Tissues;Transfer RNA;Vesicle;vesicular release;virtual;Work

PROJECT_TITLE: Extracellular vesicle-dependent RNA signaling in metabolism


NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: The proposed research is relevant to public health because understanding the demographic, molecular, and clinical basis of health across the life course in translationally-relevant nonhuman primate (NHP) species is fundamentally important to the study of human aging. Not only will this study test hypotheses regarding differences in the lifespan and healthspan of NHP species, it will generate the largest NHP lifespan database to date, create a new clinical measure for biological aging in NHPs, and identify blood-based biomarkers associated with differences in aging within and between species. Thus, this study is relevant to NIA’s mission to support genetic, biological, and clinical research on aging in furtherance of the NIH’s overall goal of seeking fundamental knowledge about the nature of living systems to enhance health and lengthen life.

PI_NAMEs: QUILLEN, ELLEN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: MORO, MANUEL H

PROJECT_TERMS: Address;Age;age acceleration;age related;Aging;aging biomarker;aging related disease;Animals;Automobile Driving;Biochemical;Biological;biological age;Biological Aging;Biological Factors;Biological Markers;biological research;Biology;Biology of Aging;Biomedical Research;Birth;Blood Chemical Analysis;blood-based biomarker;Body Size;Callicebus cupreus;Callithrix;Cercopithecidae;Cessation of life;Chronically Ill;Chronology;Clinical;clinical biomarkers;Clinical Research;Cohort Effect;Data;Data Set;Databases;Development;Euthanasia;Evolution;exome;Female;Genes;Genetic;genetic pedigree;Genetic Research;genetic variant;Genome;Genomics;Goals;Growth;Health;healthspan;Homeostasis;Human;improved;indexing;Individual;Institution;Intervention;Knowledge;Laboratories;Late Effects;late life;Life;Life Cycle Stages;life history;life span;Link;Longevity;Macaca;Macaca mulatta;Maintenance;male;Mammals;Measures;Mediating;Methods;Mission;Modeling;Molecular;molecular marker;mortality risk;multiple omics;Nature;nonhuman primate;offspring;Organism;Outcome;Pan Genus;Paper;Papio;Pathway interactions;Pattern;Physiological;Plasma;pleiotropism;Primates;Proteome;Proteomics;Public Health;Publishing;Radiation;rate of aging;Reporting;Reproduction;reproductive;Research;research facility;Research Personnel;Risk;risk prediction;Saguinus;Saimiri;sex;Systematic Bias;Testing;tool;trait;translational model;United States National Institutes of Health;Variant;vervet;whole genome;Work

PROJECT_TITLE: Multi-omic and biological factors associated with lifespan and healthspan across NHP clades

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (M1)]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Narrative Reconstruction of large and major bone defects remains a significant challenge in orthopedic surgery. Yet, the golden treatments so far, using replacement auto or allo-grafts, struggle with many problems of immune rejection, infection, donor-site morbidity and especially, limited tissue supplies. Here, we propose a new approach to combine special biodegradable piezoelectric Poly-l-Lactide (PLLA) nanofibers with Tricalcium Phosphate (β-TCP) to create a bionic bone composite scaffold which can be activated by ultrasound (US) to electrically stimulate a complete healing of critical-sized bone defects in vivo.

PI_NAMEs: LO, WAI HONG ;NGUYEN, THANH  (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Allografting;Apatites;Biocompatible Materials;bioelectricity;Biological Products;Bionics;bioscaffold;BMP2 gene;bone;bone engineering;bone fracture repair;Bone Growth;bone healing;Bone Regeneration;Bone Resorption;bone scaffold;Bone Transplantation;calcium phosphate;Calcium Signaling;Cartilage;Cells;Charge;Clinic;Clinical;Cues;Defect;design;Electric Stimulation;Engineering;Extracellular Matrix;Growth;Growth Factor;healing;Immune;Implant;implantable device;In Vitro;in vivo;Infection;Ions;Knowledge;Lead;long bone;Marketing;Mechanics;Medicine;Methods;Modeling;Modern Medicine;Molecular;Morbidity - disease rate;Muscle;nanofiber;Natural regeneration;Nerve;novel;novel strategies;Orthopedic Surgery;Oryctolagus cuniculus;Osteogenesis;Outcome;Output;Pharmaceutical Preparations;Physiologic Ossification;pressure;Property;Proteins;reconstruction;recruit;regenerative;Regenerative engineering;regenerative tissue;repaired;Research Personnel;response;Role;scaffold;side effect;Signal Transduction;Site;stem cells;success;Surface;Technology;timeline;tissue regeneration;tissue support frame;Tissues;Transforming Growth Factor beta;tricalcium phosphate;ultrasound;Vascular Endothelial Growth Factors;vibration

PROJECT_TITLE: Bionic Self-Charged Bone Composite Scaffold

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Post-acute rehabilitation utilization after stroke is poorly characterized, leaving us unable to improve the continuity of care, patient outcomes, and the value of rehabilitation after stroke. This proposal aims to fill this gap by comprehensively characterizing longitudinal post-acute rehabilitation utilization during the first year after stroke and determining its impact on one-year outcomes. This will establish the foundational knowledge needed to improve the value of rehabilitation after stroke.

PI_NAMEs: FRENCH, MARGARET  (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Acute;acute care;acute stroke;Address;Advisory Committees;Award;beneficiary;cardiovascular health;care systems;career;career development;Caring;Characteristics;Clinic;Clinical Sciences;Communication;Communities;community-level factor;comorbidity;Complex;Continuity of Patient Care;Data;Data Sources;Ensure;Epidemiologist;experience;Foundations;functional outcomes;Goals;Health;Health Services;Health Services Research;Healthcare;Healthcare Systems;Home;hospital care;hospital readmission;Hospitalization;Hospitals;improved;improved mobility;indexing;Individual;innovation;Inpatients;Interruption;Knowledge;Leadership;Machine Learning;machine learning prediction;Medicare;Mentored Research Scientist Development Award;Mentors;Modeling;mortality;multidimensional data;neurological rehabilitation;Outcome;outcome prediction;Outpatients;Patient-Focused Outcomes;Patients;Pattern;Persons;Policies;Positioning Attribute;post stroke;predictive modeling;primary outcome;prospective;Quality of life;Recovery;rehabilitation service;Rehabilitation therapy;rehabilitative care;Research;Research Personnel;Resources;Risk Reduction;Rural;secondary outcome;Series;Severities;Shapes;Skilled Nursing Facilities;skills;social factors;Statistical Data Interpretation;Stroke;stroke outcome;stroke recovery;stroke rehabilitation;Structure;Subgroup;System;Time;Training;Translational Research;United States;Universities;Utah;Wit;Work

PROJECT_TITLE: Characterizing longitudinal post-acute rehabilitation utilization and outcomes during the first year after stroke in Medicare beneficiaries

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


ORG_CITY: NEW YORK

ORG_DEPT: CHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative This research will provide a molecular view for how antibiotic resistance is conferred to pathogenic Staphylococcus aureus. Our research will also propose and validate a novel inhibitor type for blocking an important antibiotic resistance mechanism, with the long-term goal of using these compounds in combination with existing antibiotics.

PI_NAMEs: KOIDE, SHOHEI ;TRAASETH, NATHANIEL J. (contact);WANG, DANENG

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Active Biological Transport;Animals;antibiotic efflux;Antibiotic Resistance;Antibiotics;Antibodies;Arginine;Binding;Charge;chemical synthesis;computational chemistry;Coupled;Cryoelectron Microscopy;Cytoplasm;Data;design;Drug resistance;drug resistant bacteria;Drug Transport;Effectiveness;efflux pump;Electrostatics;extracellular;global health;Goals;Human;Hybrids;Immunoglobulin Fragments;Infection;inhibitor;Ions;Knowledge;Microbiology;miniaturize;Molecular;Molecular Conformation;multidrug transport;NMR Spectroscopy;novel;Organism;pathogenic bacteria;Pathogenicity;Peptides;Pharmaceutical Preparations;Protein Engineering;Proteins;Research;resistance mechanism;Resolution;Side;Specificity;Staphylococcus aureus;structural biology;Structure;Synthesis Chemistry;System;Toxic effect

PROJECT_TITLE: Transport Mechanisms and Inhibition of Efflux Pumps in Pathogenic Organisms

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative: Clinical bulk samples contain mixed cell types, resulting to an admixture of signals from multiple pure compo- nents. We propose to develop novel statistical approaches to address the problem of cell type mixture identifi- cation for subjects with multiple observations, construct methods to estimate individual-specific pure profile ref- erences, and retrieve more accurate cell type mixture proportions at individual levels. Our project will break new ground for many studies by enabling the investigation of personalized pure cell type associations with the disease outcome, and the individual-level, cell-type-specific biomarker discovery.

PI_NAMEs: FENG, HAO  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Accounting;Address;Admixture;Algorithms;Benchmarking;Biological;Biological Markers;biomarker discovery;cell type;Clinical;Computer software;Data;data mining;Diabetes Mellitus;differential expression;Disease Outcome;disorder risk;Environmental Risk Factor;epigenetic marker;Gene Expression Profile;Gene Expression Profiling;Genes;Genomics;Heterogeneity;improved;Individual;Insulin-Dependent Diabetes Mellitus;Investigation;laboratory experiment;Measures;Methods;Modeling;mosaic;novel;Parkinson Disease;personalized genomics;Persons;Population;programs;Research;Resolution;Resources;risk prediction;Sampling;Series;Signal Transduction;specific biomarkers;Statistical Methods;success;Testing;Tissue-Specific Gene Expression;tool;transcriptome;transcriptomics;Work

PROJECT_TITLE: Personalized genomics signal deconvolution to improve cell-type level inference

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Machine Learning and Artificial Intelligence;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Dopaminergic neurons are particularly sensitive to age-related oxidative stress, and evolutionary changes in the human lineage exacerbate this vulnerability by extending lifespan and disproportionately expanding axonal target regions, while requiring increased innervation density in multiple basal ganglia regions. We will use experimental, computational, and functional methods in human and non-human primate stem cell-derived dopaminergic neurons, complemented by analysis of primary brain substantia nigra tissue to identify human-specific oxidative stress-responsive regulatory elements and genes supporting neuroprotective compensatory adaptations. As many age-related disorders involve damage from oxidative stress, understanding evolved mechanisms of neuroprotection in a particularly vulnerable neuron will support general strategies aimed at targeting dynamic oxidative stress responsive elements and pathways in aging.

PI_NAMEs: POLLARD, KATHERINE S.;POLLEN, ALEXANDER A (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Address;Age;age related;age-related disease;Aging;Autopsy;Axon;Basal Ganglia;biological adaptation to stress;Brain;brain cell;Brain region;Buffers;cell age;Cell fusion;cell type;Cells;cellular targeting;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;convolutional neural network;Corpus striatum structure;Coupled;CRISPR interference;Cytoprotection;Data;Death Rate;density;Dependence;design;Development;Disease;DNA Sequence;dopaminergic neuron;Elements;Evolution;Exhibits;experience;experimental analysis;Exposure to;extend lifespan;Free Radicals;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Complementation Test;Genetic Variation;genomic data;Genomics;hindbrain;Human;human tissue;Inflammation;innovation;interdisciplinary approach;Joints;life span;loss of function;Macaca;Macaca mulatta;Machine Learning;Measurement;Measures;Mediating;Methods;Midbrain structure;Modeling;Mutation;nerve supply;Neurodegenerative Disorders;Neurons;neuroprotection;nonhuman primate;Organ;Organoids;oxidative damage;Oxidative Stress;Pan Genus;Parkinson Disease;Pathway interactions;Phylogeny;Pongo pygmaeus;Population;predictive tools;Primates;Property;protective factors;protective pathway;Regulator Genes;Regulatory Element;response;screening;Sequence Analysis;sequence learning;Statistical Data Interpretation;stem cell organoids;stem cells;Stimulus;Stress;stressor;Structure;Substantia nigra structure;Telencephalon;Tissues;Training;Validation;Variant

PROJECT_TITLE: Human‐specific vulnerabilities and compensatory adaptations to age‐related stressors in selectively vulnerable midbrain dopaminergic neurons


NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Rare Diseases;Sickle Cell Disease

PHR: Project Narrative We have found that sickle red blood cells can directly activate neutrophils, resulting in abnormal neutrophil function. In this application, we will define the properties of sickle red blood cells which cause neutrophils to become activated, and we will determine the consequences which occur as a result of neutrophil activation. These findings may provide new explanations for how complications occur in sickle cell disease and may identify new strategies to prevent such complications.

PI_NAMEs: LEE, GRACE MING (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Abnormal Hemoglobins;Abnormal Neutrophil;Activities of Daily Living;Acute;acute chest syndrome;adhesion receptor;Adhesions;Adhesiveness;Adhesives;Adopted;Affect;Animal Model;Biological;Biological Markers;Blood Platelets;CD44 gene;CD47 gene;Cell Communication;Cell membrane;Cell surface;Characteristics;Chronic;clinical predictors;Complement;Complex;cytokine;Data;Diagnosis;Disease;Endothelial Cells;Endothelium;Erythrocytes;Event;Exposure to;extracellular;Frequencies;Functional disorder;Future;Gene Expression;Gene Expression Profile;Genetic Transcription;Heme;Hemolysis;Hospitals;Immunophenotyping;improved;In Vitro;in vivo;Inflammation;Inflammation Mediators;insight;Measures;Mediator;Methods;Monitor;Morbidity - disease rate;neutrophil;Neutrophil Activation;new therapeutic target;novel;novel therapeutic intervention;Observational Study;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphatidylserines;Play;Polymers;Predisposition;prevent;Property;Reporting;response;Role;Severities;Sickle Cell;Sickle Cell Anemia;sickling;Stimulus;Surface Antigens;Testing;transcriptome sequencing;Transfusion;Treatment Efficacy;Work

PROJECT_TITLE: RBC Effects on Neutrophil Activation and Phenotypes in Sickle Cell Disease

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: YES for CURE Project Narrative  Increasing the participation and retention of underrepresented minorities (URMs) in cancer-related STEM fields is critical for eliminating cancer disparities and improving cancer outcomes in the United States. Early engagement in scientific research has been linked to enrollment and retention of students in STEM degree programs and careers. The Young Empowered Scientists for ContinUed Research Engagement (YES for CURE) Program, in the Dana-Farber/Harvard Cancer Center, is a multi-year holistic and comprehensive cancer and cancer disparities research experience and education program for URM high school and undergraduate students in the Greater Boston area.

PI_NAMEs: DECAPRIO, JAMES A. (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Address;Adult;anti-cancer research;Area;Awareness;Bachelor's Degree;Black race;Boston;Cancer Burden;Cancer Center;cancer health disparity;career;career awareness;Career Choice;Career Exploration;Censuses;Clinical;clinical care;cohort;college;Communities;community engagement;community partners;cultural competence;Curiosities;curriculum development;Decision Making;Degree program;Detection;disadvantaged background;Discipline of Nursing;economic disparity;Economically Deprived Population;Education;Education Projects;Educational Curriculum;Educational process of instructing;empowerment;Enrollment;Environment;Ethics;ethnic diversity;Ethnic Origin;experience;Faculty;Family;Funding;Goals;graduate school;Health;health disparity;high school;high school program;Hispanic;improved;Incidence;Individual;Infrastructure;innovation;insight;Institution;Investments;junior high school;Knowledge;Link;Malignant Neoplasms;Measurable;Medical;Medicine;Mentors;mortality;NCI Center for Cancer Research;Oncology;Outcome;outreach;outreach program;Participant;Population;Prevalence;Prevention;Principal Investigator;Process;programs;Race;racial diversity;Research;research in practice;Research Project Grants;Research Training;Science;Science, Technology, Engineering and Mathematics Education;Scientist;skill acquisition;skills;socioeconomic disadvantage;socioeconomic disparity;STEM career;STEM curriculum;STEM field;STEM research;student retention;Students;success;Supervision;Talents;Thinking;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;United States;Universities;Work;Writing

PROJECT_TITLE: The Young Empowered Scientists for ContinUed Research Engagement (YES for CURE) Program at the Dana-Farber/Harvard Cancer Center (DF/HCC)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: DIAN FOSSEY GORILLA FUND I

ORG_STATE: GA

PHR: PROJECT NARRATIVE While one of the most remarkable features of the human species is our capacity for extreme longevity, understanding the marked variation in life spans within and between populations and the capacity for further life span extension are key priorities for aging research that can be informed by comparative research. This study leverages 170 years of rich life course data from three wild populations of humans’ closest living evolutionary relatives, chimpanzees and gorillas, to determine how variation in the prevalence of and resilience to early life adversity shapes the capacity to achieve long life span. Specific aims will determine how the response to early life adversity shapes variation in individual risk of mortality and frailty within populations and between sexes, and evaluate the effects of early life adversity on population and species differences in aging and life span.

PI_NAMEs: CAMPOS, FERNANDO ALONSO;LONSDORF, ELIZABETH VINSON;MCFARLIN, SHANNON C (contact);THOMPSON, MELISSA EMERY

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Acceleration;Address;Adolescent;Adult;African;Age;age related;Aging;aging demography;Animals;Biological;biological systems;Birth;Cicatrix;cohort;comparative;Complex;Data;Data Set;Demography;Disparity;early life adversity;Ecology;Environment;Evolution;Exhibits;experience;extend lifespan;falls;frailty;Frequencies;Funding;Gender;Gorilla gorilla;Grant;Growth;Health;health assessment;healthspan;Heterogeneity;Hominidae;Human;Individual;individual variation;Inequality;Infant;Influentials;insight;Intervention;Lead;Life;Life Cycle Stages;Life Expectancy;life history;life span;Link;Longevity;longitudinal dataset;Longitudinal Studies;Malnutrition;Measures;Modeling;models and simulation;Monitor;Morbidity - disease rate;mortality;mortality risk;Nature;nonhuman primate;novel;Outcome;Pan Genus;Pattern;Phenotype;Physiological;Pongidae;Population;Prevalence;Primates;Prospective Studies;Recording of previous events;Research;Research Priority;resilience;response;Running;Sampling;senescence;Severities;sex;Sex Differences;Shapes;simulation;social;Social Behavior;Social Conditions;social determinants;social disparities;Social Gradients;Source;species difference;standardize measure;Stress;Structure;study population;Survivors;survivorship;System;Testing;trait;Trauma;Variant;Work

PROJECT_TITLE: Great apes and the evolutionary origins of long life: the influences of early life adversity on lifespan and individual frailty in wild chimpanzees and gorillas