ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Environmental factors that can be modified at community-scale, including air pollution and features of the built and natural environment, may affect the risk of developing diabetes. Better understanding of the relationship between environmental factors and diabetes will help in the development of cost-effective policies to protect public health and reduce health inequality—critical parts of the NIH mission. This study will investigate these relationships in Hispanic Community Health Study/Study of Latinos and help to understand the inter- relationship between development of diabetes and traffic-related air pollution, the neighborhood built environment, and the intensity and location of physical activity.

PI_NAMEs: KAUFMAN, JOEL DANIEL (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Accelerometer;Address;Adult;Affect;Air Pollutants;Air Pollution;Ancillary Study;Area;Benefits and Risks;Biological;built environment;Cardiovascular Diseases;Cause of Death;Characteristics;Clinical;clinical examination;Cluster Analysis;cohort;Cohort Studies;Communities;cost;cost effective;Data;Development;Diabetes Mellitus;diabetes risk;Diet;Dimensions;Direct Costs;Disparate;Environment;Environmental Exposure;Environmental Impact;Environmental Risk Factor;Ethnic Origin;Exercise;Exposure to;Facilities and Administrative Costs;Funding;Genetic;Genetic Predisposition to Disease;Genomics;Genotype;glycemic control;Glycosylated hemoglobin A;Green space;Health;health disparity;Health Food;health inequalities;Heterogeneity;high risk population;Hispanic;Hispanic Community Health Study/Study of Latinos;Incidence;Individual;knowledge base;Latino Population;Link;Location;low socioeconomic status;Measurement;Measures;Meta-Analysis;Metabolic;Metabolic Diseases;metabolomics;meter;Methodology;metropolitan;Mission;Modeling;Modification;Monitor;mortality;multiple omics;Neighborhoods;Nitrogen Dioxide;Nitrogen Oxides;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome Measure;Ozone;Participant;Particulate Matter;Persons;Phenotype;Physical activity;Play;Policies;Pollution;Population;Prediabetes syndrome;Prevalence;protective factors;Psychosocial Factor;Public Health;Race;Relative Risks;Research;Resources;Respiratory Disease;Risk;Risk Factors;Risk Reduction;Role;Series;Socioeconomic Status;Source;traffic-related air pollution;United States National Institutes of Health;urban disparity;Urban Population;urban setting;Visceral;walkability

PROJECT_TITLE: SOLAir: Environmental Factors and Diabetes Development in Latinos

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-E(02)]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: DALLAS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSURGERY

ORG_FIPS: US

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Despite significant advances in human neurosciences emerging from direct intracranial recordings of brain activity in human volunteers, it can be difficult to fully interpret these signals because of an incomplete understanding of the factors that affect their quality and patterns. This is further complicated by the relative rarity of these signals which make it challenging to conduct the large scale studies that are needed to study the factors that may contribute to signal variability, such as underlying brain anatomy. In this project, we use the power of numbers derived from the Data Archive for the BRAIN Initiative which hosts data from over 535 subjects from 24 institutions to create a large integrated multimodal dataset to enable large scale analyses of these brain signals and their significance, especially as it pertains to the influence of brain anatomy on these neural signals.

PI_NAMEs: DUNCAN, DOMINIQUE ;POURATIAN, NADER  (contact)

PROGRAM_OFFICER_NAME: JANES, DANIEL ERIC

PROJECT_TERMS: Address;Affect;Age;analytical tool;anatomic imaging;Anatomy;archive data;archived data;Archives;Back;Biological;Brain;BRAIN initiative;connectome;Data;data archive;data curation;Data Element;data integration;Data Set;data standards;Deposition;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Documentation;Electroencephalography;Ensure;Frequencies;Funding;Future;Growth;Human;Human Resources;Human Volunteers;Image;image processing;Individual;Informatics;insight;Institution;Intervention;Investigation;Investments;Lead;Learning;Link;Literature;Magnetic Resonance Imaging;Measures;Methods;morphometry;Motor Cortex;multimodal data;multimodality;Nature;neural;neural patterning;neuroimaging;neurophysiology;neuropsychiatric disorder;Neurosciences;neurosurgery;neurotransmission;Noise;novel;Patients;Pattern;Physiology;Population;Process;Property;Quality Control;Research;Research Personnel;Resolution;Resources;Roentgen Rays;Role;signal processing;Signal Transduction;Site;Source;spatial integration;Specificity;Standardization;Structure;Thalamic structure;Thick;Time;tool;Training Activity;United States National Institutes of Health;volunteer;webinar;Work

PROJECT_TITLE: BRAIN Integrated Resource for Human Anatomy and Intracranial Neurophysiology


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Rural Health

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

ORG_STATE: MD

PI_NAMEs: MILLER, AMY  (contact)

PROJECT_TERMS: Affect;Agricultural Health Study;Agriculture;Carcinogens;cohort;Collaborations;Contractor;Contracts;Disease;Enrollment;Farm;farmer;follow-up;Funding;Genetic;Health;Iowa;Licensing;Life Style;Link;Malignant Neoplasms;mortality;National Cancer Institute;National Institute of Environmental Health Sciences;North Carolina;Outcome;Pesticides;Phase;Population;Probability;Prospective Studies;Questionnaires;Registries;Spouses;United States Environmental Protection Agency;Update

PROJECT_TITLE: THE SIXTH PHASE OF THE AGRICULTURAL HEALTH STUDY CONTRACT


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BOULDER

ORG_NAME: CRESTONE, INC.

ORG_STATE: CO

PI_NAMEs: OSCHNER, URS  (contact)

PROJECT_TERMS: Advanced Development;antimicrobial resistant infection;Bacterial Drug Resistance;bacterial resistance;biodefense;candidate selection;Chemistry;Clinical assessments;Clostridium difficile;Combating Antibiotic Resistant Bacteria;efficacy evaluation;Emerging Communicable Diseases;lead optimization;manufacture;pathogen;Phase I Clinical Trials;pre-clinical;product development;research and development;Research Support;safety assessment;Therapeutic;therapeutic candidate;therapeutic development

PROJECT_TITLE: Development of Therapeutic Products for Biodefense, AntiMicrobial Resistant (AMR) Infections and Emerging Infectious Diseases


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: Willowbrook

ORG_NAME: IMMUNARTES LLC

ORG_STATE: IL

PI_NAMEs: THAMMAVONGSA, VILASACK  (contact)

PROJECT_TERMS: Advanced Development;Animal Model;Bacterial Drug Resistance;bacterial resistance;biodefense;Clinical;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Contracts;Disease Outbreaks;efficacy evaluation;efficacy testing;Emerging Communicable Diseases;Formulation;immunogenicity;Individual;manufacture;response;Safety;stability testing;Staphylococcus aureus;Toxicology;vaccine candidate;vaccine development;Vaccines

PROJECT_TITLE: Advanced Development of Vaccine Candidates for Biodefense and Emerging Infectious Diseases


NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: BOCIK, WILLIAM  (contact)

PROJECT_TERMS: Acceleration;Affinity;Aftercare;anti-cancer research;Antibodies;assay development;Benchmarking;Biological;Biological Assay;Biomedical Research;Biopsy Specimen;Clinical;Clinical Trials Network;Communities;Competence;Complex Mixtures;Core Biopsy;Custom;early phase clinical trial;genome analysis;improved;Investigational Therapies;Laboratories;Liquid substance;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;Measurement;method development;Methods;Modeling;Molecular;National Cancer Institute;patient derived xenograft model;Patients;Peptides;Pharmacodynamics;Phosphorylation;Post-Translational Protein Processing;programs;Proteins;proteogenomics;Proteome;Proteomics;Reagent;repository;Research Institute;Specimen;Standardization;Tissues;Translating;translational cancer research;treatment effect;tumor

PROJECT_TITLE: THIS TASK ORDER IS FOR THE PROTEOMIC CHARACTERIZATION LABORATORY.


ADMINISTERING_IC: FD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: CHICAGO

ORG_NAME: ILLINOIS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Since 1988, NCFST has received support from the FDA under seven previously awarded cooperative agreements (53 FR 15736; 56 FR 46189; 59 FR 24703; 64 FR 39512; 69 FR 25405; 74 FR 26408; and 80 FR 43095). This five-year renewal award provides continued support to the collaborative research, education and outreach programs related to the safety of food processing technologies and processed foods, and further improves public health.

PI_NAMEs: SCHANEBERG, BRIAN TODD (contact)

PROGRAM_OFFICER_NAME: SMOOT, LESLIE

PROJECT_TITLE: Institute for Food Safety and Health National Center for Food Safety and Technology Cooperative Agreement Renewal Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CFSN-T (03)]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PI_NAMEs: CHATTERJEE, ARNAB KUMAR (contact)

PROJECT_TERMS: Adjuvant;aluminum sulfate;Antigens;Biochemical;Biological Assay;Clinical Trials;Contracts;Development;Dose;End Point Assay;first-in-human;Formulation;HIV;HIV vaccine;HIV-1;immunogenicity;Immunologics;In Vitro;in vivo;Mus;National Institute of Allergy and Infectious Disease;novel;novel strategies;pharmacokinetics and pharmacodynamics;Preclinical Testing;Protocols documentation;screening;Standardization;Testing;vaccine candidate;vaccine development

PROJECT_TITLE: Rational Systemic Characterization and Selection of Adjuvants for HIV Vaccine Candidates (R-CASA)


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: FLAGSTAFF

ORG_NAME: NORTHERN ARIZONA UNIVERSITY

ORG_STATE: AZ

PI_NAMEs: BALDWIN, JULIE ANN (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Address;Advisory Committees;American Indians;Area;Arizona;Behavioral Research;Benchmarking;Biomedical Research;Budgets;cancer prevention;career;Clinical Research;Collaborations;Communities;community partners;Creativeness;Data;Decision Making;design;Development;Ensure;Evaluation;experience;Feedback;Funding;Goals;Government;health disparity;health disparity populations;health equity;Health equity research;Hispanic;Human Resources;improved;Individual;Infrastructure;innovation;Institution;institutional capacity;Latinx;Leadership;Logic;meetings;microbiome;Minority-Serving Institution;model design;Monitor;Native American Research Center for Health;Native Americans;Outcome;Output;pathogen;programs;Recommendation;Reporting;Research;research and development;Research Personnel;Research Project Grants;Resources;Schedule;Science;Southwestern United States;Strategic Planning;success;System;Targeted Research;Time;training opportunity;translational approach;Universities;Vision

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research

ORG_STATE: WA

PI_NAMEs: PSATY, BRUCE  (contact)

PROJECT_TERMS: Address;Agreement;Area;biobank;Biological;cardiovascular health;Contractor;Contracts;data repository;Data Set;Funding;Image;Location;National Heart, Lung, and Blood Institute;Performance;Preparation;Process;programs;Progress Reports;Protocols documentation;Recommendation;Reporting;research study;Scanning;Specimen;timeline;Work

PROJECT_TITLE: CARDIOVASCULAR HEALTH STUDY (CHS) - TASK AREA C, STUDY CLOSEOUT


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Substance abuse disorders are a chronic human condition where initial consumption leads to long-lasting behavioral changes, driven in part by initial, and then progressive resistance to the intoxicating effects of alcohol as tolerance develops. The results of the proposed studies will provide valuable mechanistic insight into the way initial ethanol exposure causes these long-lasting behavioral changes. This will highlight novel targets for therapeutic intervention with alcohol addiction, which are largely lacking.

PI_NAMEs: ROTHENFLUH, ADRIAN  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Actins;Acute;addiction;Affect;Alcohol abuse;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;Alcohol Phenotype;alcohol response;alcohol sensitivity;alcohol use disorder;Alcoholic Intoxication;Alcohols;Anatomy;Antidotes;Area;ATAC-seq;Automobile Driving;Behavior;Behavior Control;Behavioral;Behavioral Mechanisms;behavioral response;Binding;Biological;Brain;Candidate Disease Gene;candidate identification;candidate validation;Cells;Chromatin;Chronic;Collaborations;Consumption;Cytoskeleton;Data;Dependence;Development;Disease;DNA;dopaminergic neuron;driving force;Drosophila genus;Elements;Engineering;Enhancers;epigenome;Ethanol;experimental study;Family;Feasibility Studies;fly;Funding;gamma-Aminobutyric Acid;Gene Expression Regulation;Genes;Genetic;genetic approach;Genetic Predisposition to Disease;Genetic Transcription;genome wide association study;Goals;Grant;GTPase-Activating Proteins;Guanine;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;Health;Health Hazards;Human;Human Genome;improved;in vivo;in vivo evaluation;Individual;inhibitor;innovation;insight;interest;Intervention;Intoxication;Link;Location;Measures;Mediating;member;Methods;model organism;Modeling;Molecular;Monomeric GTP-Binding Proteins;Motor;National Institute on Alcohol Abuse and Alcoholism;neural;neural circuit;Neurons;Neurotransmitters;new therapeutic target;Nucleic Acid Regulatory Sequences;Orthologous Gene;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Populations at Risk;preference;Promoter Regions;Protein Isoforms;Publications;Publishing;rational design;Regulation;Regulator Genes;Regulatory Element;Research;Research Personnel;Resistance;response;Rewards;rho;rho GTP-Binding Proteins;Risk Factors;Role;RSU1 gene;Sedation procedure;Signal Transduction;Societies;Specificity;Substance abuse problem;System;Testing;Therapeutic Intervention;Tissue-Specific Gene Expression;Tissues;transcription factor;Transcriptional Regulation;transcriptome;transcriptomics;translational approach;translational impact;Translational Research;United States

PROJECT_TITLE: Control of Alcohol Responses by Actin-Regulating Genes

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_DEPT: SURGERY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PI_NAMEs: KOBLINSKI, JENNIFER E (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Advanced Malignant Neoplasm;advanced system;Archives;Bioinformatics;Biological Specimen database;Black Populations;Black race;Breast;Cancer Center;cancer subtypes;cancer type;Carcinomatosis;central database;Characteristics;Clinical;Collaborations;Collection;Communication;Communities;Data;Data Commons;Development;Diagnosis;Educational workshop;Equity;ethnic diversity;ethnic minority population;gastrointestinal;Genitourinary system;Genomics;Gynecologic;Health Disparities Research;health equity;Histologic;immunohistochemical markers;improved;Investigation;Latinx;Libraries;Link;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Massey Cancer Center at the Virginia Commonwealth University;meetings;Minority Groups;Modeling;Molecular;multiple omics;operation;Organoids;Pancreas;Pancreatic Adenocarcinoma;patient derived xenograft model;patient population;Patients;Peritoneal;personalized approach;Pilot Projects;Population;Preclinical Testing;Primary Neoplasm;Program Research Project Grants;programs;Quality of Care;racial diversity;racial minority population;relational database;repository;Research;Research Project Grants;Research Support;RNA;safety net;Sampling;Site;Specimen;System;therapeutic development;Tissue Expansion;Tissue Harvesting;tumor;Tumor Tissue;Underrepresented Minority;Underrepresented Populations;Universities;Virginia

PROJECT_TITLE: PDX Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project 1 NARRATIVE Ovarian cancer is a significant cause of morbidity and mortality that affects nearly 300,000 women worldwide each year, and its poor outcomes are related to delayed diagnosis and development of resistance to conventional therapy with carboplatin, paclitaxel and PARP inhibitors. Inhibition of salt induced kinase 2 (SIK2) has enhanced sensitivity to all three agents. Our proposal will explore the ability of GRN-300, a SIK-2 inhibitor, to enhance response to the PARP inhibitor olaparib and to immune checkpoint blockade, enhancing their antitumor activity.

PI_NAMEs: BAST, ROBERT C (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Affect;Binding;Biopsy;Blood;brca gene;BRCA mutations;cancer cell;Cancer cell line;cancer immunotherapy;Cancer Model;cancer type;Carboplatin;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;checkpoint therapy;Chromatin;Clinical;conventional therapy;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Diagnosis;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Gene;DNA Repair Inhibition;DNA Repair Pathway;DNA replication fork;DNA Sequence Alteration;Dose;Double Strand Break Repair;Enhancers;Excision;Exhibits;EXO1 gene;experience;FANCD2 protein;first-in-human;FOXP3 gene;Frequencies;Gene Expression;Genetic Transcription;Germ Lines;Goals;HDAC4 gene;homologous recombination;homologous recombination deficiency;Human;IL2RA gene;IL6 gene;immune checkpoint blockade;Immunotherapy;Impairment;Infiltration;inhibiting antibody;inhibitor;IRF3 gene;ITGAM gene;Malignant neoplasm of ovary;Malignant Neoplasms;Marrow;Maximum Tolerated Dose;Mediating;Messenger RNA;Modeling;Morbidity - disease rate;mortality;mouse model;mRNA Expression;Mus;Muscle Cells;Myeloid-derived suppressor cells;Myelosuppression;Names;novel;Nuclear;Nucleic Acid Regulatory Sequences;Organoids;Outcome;Ovarian;Paclitaxel;Pathway interactions;patient derived xenograft model;Patients;Peripheral Blood Mononuclear Cell;Phase;Phase I Clinical Trials;phase I trial;Phase Ib Trial;Phosphorylation;Phosphotransferases;Platinum;Play;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;preclinical study;prevent;Primary Neoplasm;programmed cell death ligand 1;Progression-Free Survivals;recombinational repair;refractory cancer;Regulatory T-Lymphocyte;Relapse;Repression;Resistance;Resistance development;response;restoration;Sampling;Second Look Surgery;Site;Sodium Chloride;Stimulator of Interferon Genes;T cell infiltration;T-Lymphocyte;targeted agent;TBK1 gene;Testing;TGFB1 gene;Toxic effect;transcriptome sequencing;tumor;Woman;Xenograft procedure

PROJECT_TITLE: The SIK2 Inhibitor GRN-300 Enhances PARP Inhibitor Sensitivity and Cytotoxic T-Cell Function in Ovarian Cancer


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative An understanding of women and their tobacco-related issues, as well as the need for the development of gender-relevant tobacco control efforts, have been highlighted as priorities in landmark guiding documents (e.g., WHO Framework Convention on Tobacco Control). We propose to adapt an efficacious culturally- and gender-relevant Community Health Worker (CHW)-led tobacco cessation intervention to be integrated with a mHealth application among low-income Brazilian women that augments the tobacco cessation program offered through the public health system.

PI_NAMEs: SCARINCI, ISABEL C (contact)

PROGRAM_OFFICER_NAME: PEARLMAN, PAUL C

PROJECT_TERMS: Abstinence;Address;Appointments and Schedules;Brazil;Carbon Monoxide;Cellular Phone;Cigarette;Clinic;Collaborations;Community Health Aides;Community Health Systems;comparison group;Consumption;coping;Development;disadvantaged women;Effectiveness;effectiveness evaluation;efficacious intervention;Evaluation;Exhalation;Feedback;Fogarty International Center;formative assessment;Funding;Gender;Geographic Locations;handheld mobile device;Health;Health Personnel;Health system;Health Technology;Healthcare;Healthcare Systems;Home visitation;Infrastructure;Intervention;intervention mapping;Low income;Measurement;Measures;Methodology;mHealth;mhealth interventions;Mobile Health Application;Modeling;Monitor;National Cancer Institute;Neighborhoods;Online Systems;Paper;Participant;Patient Recruitments;Patient Self-Report;Penetration;Phase;pilot test;Politics;Population Intervention;Prevalence;primary care clinic;programs;prototype;Public Health;Randomized;randomized trial;recruit;Relapse;Research;Resource-limited setting;retention rate;Rural;Schedule;skills;Smoker;smoking cessation;social cognitive theory;Socialization;Structure;success;symposium;System;Technology;Testing;theories;Time;Tobacco;tobacco cessation intervention;tobacco control;Tobacco Use Cessation;tool;Underinsured;Withdrawal Symptom;Woman;Work;World Health Organization

PROJECT_TITLE: Adaptation and Evaluation of a Culturally- and Gender-Relevant Tobacco Cessation among Women in Brazil: An Integrated mHealth Approach


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PI_NAMEs: SPEICHER, DAVID W. (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Acetates;Address;Award;Biological;Biological Assay;Budgets;Cancer Biology;cancer cell;Cancer cell line;Cancer Center;Complex;Consultations;cost;cost effective;Dedications;Detection;Development;Electrospray Ionization;Energy-Generating Resources;Ensure;experimental study;fatty acid oxidation;Fatty Acids;Fox Chase Cancer Center;Fractionation;Funding;Future;Gel;Genes;Genus Hippocampus;Glucose;Glutamine;Goals;Grant;High Pressure Liquid Chromatography;Human;Hybrids;Immunologics;improved;innovation;Institution;instrument;instrumentation;interest;Ions;Isotopes;Label;lipidomics;Lipids;Liquid substance;mass spectrometer;Mass Spectrum Analysis;Measurement;member;Metabolic;metabolic phenotype;metabolomics;Methods;Mitochondria;nano;NCI-Designated Cancer Center;oxidation;Pathway interactions;Performance;Post-Translational Protein Processing;Protein Analysis;Proteins;Proteome;Proteomics;Reagent;Research Personnel;Resistance;Resolution;Resource Sharing;Respiration;Running;S10 grant;Sampling;Secondary to;Serum;Services;Speed;stable isotope;Stable Isotope Labeling;System;Technology;Tissues;Tracer;tumor;tumor metabolism;Tumor Tissue;ultra high pressure;Universities

PROJECT_TITLE: Proteomics and Metabolomics Shared Resource


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: REHKOPF, DAVID H (contact)

PROGRAM_OFFICER_NAME: HARDESTY, REBECCA ANNE

PROJECT_TERMS: Address;Area;Behavioral;Cancer Burden;Cancer Etiology;cancer prevention;career;Categories;Centers for Population Health;Collaborations;Collection;Colorectal Cancer;Communities;community partners;County;Data;Data Collection;data curation;data dashboard;data resource;Dedications;Development;Disease;Doctor of Philosophy;Ensure;Environmental Risk Factor;experimental study;Funding;Health Sciences;Incidence;Income;Individual;Inequity;insight;interoperability;Intervention;intervention program;Latino;Leadership;Long-Term Effects;Malignant Neoplasms;mathematical model;Measures;Methodology;Methods;Mission;Modeling;Natural experiment;Pilot Projects;Play;poor communities;Population;Poverty Areas;prevent;Prevention;Prevention Research;Process;Productivity;Reproducibility;Research;Research Methodology;Research Personnel;Research Project Grants;Role;social factors;social health determinants;Surveys;synergism;Training;Universities;Vietnamese;Work

PROJECT_TITLE: Research and Methods Core


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Pediatric;Prevention

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative: Well-designed research is urgently needed to examine the impact of environmental exposures on health outcomes in children. The Duke Clinical Research Institute (DCRI) proposes to leverage its resources as the world’s largest academic research organization to continue its success serving as the Coordinating Center of the Environmental influences on Child Health Outcomes (ECHO) Program with a specific focus on monitoring progress of the study, maintaining study functions, and evaluating ECHO progress.

PI_NAMEs: ADAIR, LINDA S;SMITH, PHILLIP BRIAN (contact)

PROGRAM_OFFICER_NAME: ARTEAGA, SONIA S

PROJECT_TERMS: Address;Administrative Supplement;biobank;Child;Child Health;Childhood;Clinical Research;Clinical Trials Network;cohort;Cohort Studies;Communication;Enrollment;Ensure;Environmental Exposure;Environmental Impact;Evaluation;experience;Goals;Health;Individual;innovation;Institutional Review Boards;Intervention Studies;Knowledge;Laboratories;Monitor;operation;Outcome;Pediatric cohort;programs;Protocols documentation;recruit;Research;Research Design;Research Institute;Resources;Site;Spanish;Standardization;success;Testing;Translating;Universities

PROJECT_TITLE: ECHO Coordinating Center (CC) -  Administrative Supplement


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: SILVERA, PETER  (contact)

PROJECT_TERMS: AIDS prevention;Chemistry;Child;co-infection;Collaborations;Communities;Contraceptive Agents;Contracts;Development;Devices;Disease;Extramural Activities;HIV;Investigator-Initiated Research;manufacture;National Institute of Allergy and Infectious Disease;novel therapeutics;Pediatrics;Pharmacologic Substance;pre-clinical;Prevention;Private Sector;product development;Research;research clinical testing;research study;Resources;Science;Services;therapeutic development;treatment optimization

PROJECT_TITLE: Expertise in Professional Pharmaceutical Project Management


NIH_SPENDING_CATS: Bioengineering;Data Science;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric - AIDS;Prevention

PROJECT_TERMS: AIDS prevention;Artificial Intelligence;Childhood;co-infection;Collaborations;Collection;Communities;Contraceptive Agents;Contracts;Data;Data Analyses;Data Science;Databases;design;Development;Devices;Excipients;Extramural Activities;feasibility testing;HIV;Investigator-Initiated Research;Machine Learning;Methodology;Modernization;National Institute of Allergy and Infectious Disease;novel therapeutics;Pediatrics;pre-clinical;Prevention;Private Sector;Process;product development;Research;research clinical testing;research study;Resources;Safety;Science;Services;Technology;therapeutic development;Toxic effect

PROJECT_TITLE: Use of Artificial Intelligence/Machine Learning (AI/ML) to Enhance the STEP Pediatric Excipient Database


ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PI_NAMEs: MAITRA, RANGAN  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;assay development;Basic Science;Biological Assay;cell killing;Clinical Trials;Collaborations;Communities;Contracts;Development;Devices;Extramural Activities;HIV;Investigational New Drug Application;Investigator-Initiated Research;Licensure;National Institute of Allergy and Infectious Disease;non-nucleoside reverse transcriptase inhibitors;novel therapeutics;Phenotype;pre-clinical;Private Sector;product development;Research;research clinical testing;research study;Resources;Services;Testing;Therapeutic;United States Food and Drug Administration;Work

PROJECT_TITLE: HIV Assay Development and Testing to Identify Targeted Activator of Cell Kill Molecules


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Sleep Research

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative: Urban children with asthma are at high risk for short sleep, due to an environment that jeopardizes both sleep and asthma management. Further, urban children with asthma suffer from altered immune balance, a key biological process contributing to individual differences in asthma morbidity and sleep health. In the proposed research, we will examine the effects of shortened and recovery sleep on immune balance and associated changes in lung function in urban children with allergic asthma through an experimental design.

PI_NAMEs: KOINIS MITCHELL, DAPHNE  (contact);MARSHALL, GAILEN D.

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: actigraphy;Address;adequate sleep;Adult;Age;Allergic;Asthma;Beds;Biological Process;Chronic;Clinical;clinical care;cytokine;Data;Development;Disease;Enrollment;Environment;Equilibrium;experience;Experimental Designs;experimental study;Extrinsic asthma;Guidelines;high risk;high risk population;Home;Immune;immune function;Immunologic Markers;improved;improvement on sleep;Individual Differences;Inflammatory;Interferon Type II;Interferons;Interleukin-13;Interleukin-4;Interleukin-5;Interleukin-6;Interleukins;Intervention;Knowledge;Link;Modeling;modifiable behavior;Morbidity - disease rate;neglect;novel;Participant;Plasma;Play;Polysomnography;poor sleep;Population;Populations at Risk;Protocols documentation;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Recovery;Research;Safety;Sampling;Schedule;Sleep;Sleep Deprivation;sleep health;Spirometry;Stress;Symptoms;Testing;Time;urban children;urban setting;Work

PROJECT_TITLE: Impact of Sleep Duration on Immune Balance in Urban Children with Asthma

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Highly pathogenic avian influenza (HPAI) viruses are highly transmissible in chickens, causing 100% mortality within days and leading to significant economic losses and potentially severe public health risks if transmitted to humans. This project aims to develop gene modified chickens with reduced susceptibility or resistance to HPAI and other avian viruses by genetically targeting pro-viral host factors, antiviral proteins, or viral genes. Innovatively creating a single gene modified chicken line resistant to multiple viral pathogens could dramatically reduce disease burden and economic losses in the poultry industry.

PI_NAMEs: HALFMANN, PETER JOSEPH (contact);WANG, ZHONGDE

PROGRAM_OFFICER_NAME: KABERA, CLAUDINE

PROJECT_TITLE: The Building Resistance Against Viral Entities (BRAVE) Innovation Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CVM-T (06)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Deficits in spatial learning and memory occur in many psychiatric and neurological disorders (e.g., schizophrenia, posttraumatic stress disorder, depression, Alzheimer’s disease, stroke, and traumatic brain injury), and the neural mechanism of these deficits may involve a distinct loss in specific spatial reference frames or a loss in coordination across reference frames, such as determining the appropriate action for an allocentric location and orientation (e.g., turn right when oriented north at a specific location). Further investigation of these basic neurobiological mechanisms underlying spatial navigation is critically important for establishing a complete understanding of the neural underpinnings of spatial deficits in psychiatric disorders, neurological disorders, brain disease, and stroke. Such investigation will facilitate the development of more precise diagnostic tools and therapeutic interventions to help manage or reverse these diseased and disordered brain states and on a broader level, it will further our understanding of the neural basis of episodic memory, recognizing objects from a variety of viewpoints, and potentially even inform understanding of basic organizing principles of the brain.

PI_NAMEs: WILBER, AARON A (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Alzheimer's Disease;Animals;Anterior Nuclear Group;Attention;base;Bilateral;Brain;Brain Diseases;cell type;Cells;Code;Coffee;Cues;Development;diagnostic tool;Disease;Disorientation;Distal;Episodic memory;experience;forgetting;Future;Goals;Head;Hippocampus;Home;Human;Impairment;information processing;insight;Investigation;Learning;Left;Light;Liquid substance;Location;Maps;member;Memory;Mental Depression;Mental disorders;Movement;Nervous System Disorder;neural;neurobiological mechanism;Neurobiology;Neurodegenerative Disorders;neuromechanism;Neurons;object recognition;optogenetics;Parietal Lobe;Performance;person centered;personalized diagnostics;Persons;Population;Post-Traumatic Stress Disorders;Published Comment;Random Allocation;Rattus;Rewards;Role;Route;Running;Schizophrenia;Spatial Behavior;spatial memory;Stroke;System;Testing;Therapeutic Intervention;tool;Traumatic Brain Injury;way finding

PROJECT_TITLE: Neurobiological Basis of Reference Frame Coordination for Spatial Memory to Action Transformations

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Malaria is an infectious disease that continues to cause extensive morbidity and mortality throughout tropical and sub-tropical regions of the developing world, especially among young children in sub-Saharan Africa. This project focuses on the ability of malaria parasites to avoid the human immune response and to cause severe disease. A better understanding of these processes will lead to new forms of treatment that will help to relieve the enormous public health burden that malaria inflicts on the developing world.

PI_NAMEs: DEITSCH, KIRK W (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Adhesions;Adhesives;Africa;Africa South of the Sahara;African;Anemia;Antibodies;Antibody Response;Antigenic Variation;Babesia;Binding;Biological Process;Blood Vessels;Cell surface;Cells;Cerebral Malaria;Characteristics;Child;chromatin modification;chronic infection;Communicable Diseases;Communication;Data;design;Disease;Endothelium;Epigenetic Process;Epitopes;Erythrocytes;Event;exhaust;Exposure to;Family;Freezing;Gene Activation;Gene Deletion;Gene Expression;Gene Family;Gene Modified;gene network;Gene Order;Gene Silencing;Gene Structure;Genes;Genetic Transcription;Genome;Haploidy;Heart;Human;Immune response;Immune system;Individual;Infection;Infectious Agent;Length;Malaria;malaria infection;mathematical model;Mediating;member;Membrane Proteins;Modeling;Molecular;Morbidity - disease rate;mortality;Mutation;Nature;Nonsense-Mediated Decay;Open Reading Frames;parasite genome;parasite invasion;Parasitemia;Parasites;Pattern;Persons;Phenotype;Placenta;Plasmodium;Plasmodium falciparum;Play;Population;Positioning Attribute;Pregnancy;Pregnant Women;Probability;Process;Property;Proteins;Public Health;receptor;Reporter;Role;Severities;Structure;Surface;Surface Antigens;Switch Genes;Syndrome;System;Testing;Time;Trypanosoma;Virulence;Work

PROJECT_TITLE: A structured transcriptional switching network that coordinates antigenic variation by malaria parasites

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PI_NAMEs: LAZZARA, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Actins;active control;analysis pipeline;carcinogenesis;Cell Death;Cell Line;Cell Nucleus;Cells;Collaborations;constitutive expression;Cytoskeleton;Data;Ectopic Expression;Engineering;Epidermal Growth Factor Receptor;Fiber;Glioblastoma;Image;Image Analysis;inhibitor;Intermediate Filaments;knock-down;Lead;Learning;Length;live cell imaging;Malignant Neoplasms;Membrane;Metabolic;Methods;novel;novel therapeutics;Oncogenes;overexpression;Phase;Phenotype;Process;Protocols documentation;Regulation;response;Role;Rupture;Signal Transduction;Stress;Stress and Coping;Structure;System;Testing;Therapeutic;Thick;Time;trafficking;Tubulin;tumor;Visualization;Work

PROJECT_TITLE: EGFR signaling network adaptations to overcome RAS-induced membrane stress in glioblastoma


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eating Disorders;Mental Health;Neurosciences;Nutrition;Obesity

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Eating habits that are uncontrollable and persist without respect to negative consequences are compulsive and can be observed in both obesity and eating disorders. Motivated behavior is controlled by brain circuits that are sensitive to how hungry we are, but how hunger changes the responsivity of these circuits to negative consequences associated with eating is unknown. This project will test the hypothesis that hunger modulates the communication of negative consequences to motivational brain regions, and will improve our understanding of how these mechanisms can contribute to compulsive eating.

PI_NAMEs: SMITH, NICHOLAS K (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Affective;Animal Behavior;Animals;Aversive Stimulus;Behavior;Behavioral;behavioral response;Binge Eating;Brain;Brain region;Brain Stem;Calcium;career;Communication;Complement;Compulsive Behavior;Computer Systems;Data;Development;Diet Habits;Disease;Dopamine;dopamine system;Eating;Eating Disorders;Elements;Equilibrium;Event;experimental study;feeding;Feeding behaviors;Food;Goals;Hunger;Hypothalamic structure;Image;improved;in vivo;Individual;Laboratory Study;Lead;Learning;maladaptive behavior;Mentors;mesolimbic system;motivated behavior;Motivation;Mus;neural;neural circuit;neurobehavioral;Neurobiology;neuroimaging;Neurons;neuroregulation;novel;Obesity;Pain;parabrachial nucleus;Peptides;Process;Punishment;Research;Resistance;response;Rewards;Rodent;Role;Scientist;Signal Transduction;skills;Starvation;Stimulus;success;Technical Expertise;Techniques;Testing;Training;Ventral Tegmental Area

PROJECT_TITLE: Identifying the contribution of a brainstem circuit to compulsive food seeking


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Understanding diseases, including diabetes, pancreatitis, and cancers, requires a comprehensive knowledge of how cells and tissues normally respond to stress to maintain stability. Important aspects of this are controlled by the organization and structure of the DNA within cells. We will study this biology and the important downstream (and potentially pathogenic) consequences when this normal regulation is lost.

PI_NAMEs: WASYLISHEN, AMANDA RIETTA (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Affect;Alleles;ATRX gene;Binding;Biology;Cell Differentiation process;Cells;Chromatin;Complex;Coupled;Data;DAXX gene;Deposition;derepression;Diabetes Mellitus;Disease;DNA Structure;Embryo;embryo tissue;Endogenous Retroviruses;Epigenetic Process;epigenetic regulation;epigenome;epigenomic profiling;epigenomics;Epithelial Cells;Equilibrium;Frequencies;Gene Expression;Genes;Genetic;Genetic Models;Genetic Transcription;Genome;Genomics;Germ Lines;Goals;Hematopoietic;Hematopoietic stem cells;Heterochromatin;Histone H3;Histones;Homeostasis;Human;human embryonic stem cell;Human Genome;Impairment;In Vitro;in vivo;in vivo regeneration;Individual;induced pluripotent stem cell;infancy;Injury;injury and repair;innovation;insight;Islet Cell Tumor;Knowledge;Lead;Lesion;Link;loss of function mutation;Maintenance;Malignant Neoplasms;Mediating;Mediator;Metaplasia;Modeling;Molecular;Molecular Chaperones;mouse model;Mus;mutant;Mutation;Normal tissue morphology;Outcome;Pancreas;Pancreatic Injury;Pancreatitis;Pathogenicity;Pathologic;Phenotype;Physiological;postnatal;programs;protein protein interaction;Recurrence;Regenerative response;Regulation;Repression;Research;Role;Somatic Mutation;Stress;Structure;Testing;transcriptome;transcriptomic profiling;transcriptomics;Tumor Suppression;tumorigenesis;Variant;Work

PROJECT_TITLE: Histone chaperones and cell state regulation

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Cancer is the second most common chronic disease and cause of death among those ages 65 and older and 75% of the 22 million projected cancer survivors will be 65+ by 2030. Unfortunately, persistent racial/ethnic inequities in cancer survivorship are likely to increase with the growing number and proportion of older survivors from racial/ethnic minority groups and the absence of research groups integrating aging, disparities and cancer disciplines. The “Infrastructure for Research in Equity, Aging, Cancer and Health” (I-REACH) will bring together stakeholders and researchers to support career development and increase the diversity of the scientific workforce and generate knowledge to improve health and reduce health disparities in older minority cancer survivors.

PI_NAMEs: ADAMS-CAMPBELL, LUCILE LAUREN;CARROLL, JUDITH E;DORGAN, JOANNE F;LICHTENBERG, PETER A.;MAGAZINER, JAY ;MANDELBLATT, JEANNE  (contact);RYAN, ALICE S.;SCHWARTZ, ANN G.

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Acceleration;Address;Affect;Aging;Agreement;Area;Award;Behavioral;cancer care;Cancer Center;Cancer Survivor;Cancer Survivorship;care systems;career;career development;Caring;Cause of Death;Chronic Disease;Clinical;clinical care;Clinical Research;cohort;Collaborations;Communities;Data;data resource;Databases;demographics;Discipline;Disease;Disparity;disparity reduction;Distance Learning;Educational Curriculum;Elderly;Enrollment;Equity;ethnic disparity;ethnic minority;ethnic minority population;Exposure to;Funding;Future;Geriatrics;Gerontology;Geroscience;Goals;Grant;Health;Health Care Costs;health disparity;health equity promotion;human old age (65+);improved;Infrastructure;innovation;Intervention;Investments;Knowledge;Laboratories;late life;Malignant Neoplasms;Maryland;meetings;Mentors;Methodology;Minority;minority communities;minority engagement;Minority Groups;minority scientist;mortality;older adult;Older Population;Oncology;Phase;Population;pre-doctoral;programs;Quality of life;Race;racial disparity;racial minority;racial minority population;recruit;Reduce health disparities;Research;Research Infrastructure;Research Personnel;Resources;Scholars Program;Scientist;secondary analysis;Self Efficacy;Senior Scientist;Site;social;Socioeconomic Status;Source;stakeholder perspectives;success;Survivors;Training;trend;Trust;Underrepresented Minority;United States National Institutes of Health;Universities;Variant;Woman;Work

PROJECT_TITLE: I-REACH: Infrastructure for Research in Equity, Aging, Cancer and Health


NIH_SPENDING_CATS: Cancer;Clinical Research;Diabetes;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative We have developed a network of adult and pediatric medical research institutions to form The Ohio State University Clinical Center (OSU CC). In a multidisciplinary collaboration with other clinical centers in the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer Clinical Centers (CSCPDPC- CCs) (U01), the OSU CC has helped developed 4 major observational studies during the initial funding cycle that address research gaps in our understanding of the exocrine pancreas. Specifically, the OSU CC seeks to confirm and validate proposed diagnostic biomarkers in chronic pancreatitis, pancreaticogenic diabetes and pancreas cancer.

PI_NAMEs: CONWELL, DARWIN LEWIS;HART, PHILIP A. (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Abdominal Pain;Address;Adult;Aliquot;Ancillary Study;Applications Grants;Artificial Intelligence;Basic Science;Big Data Methods;Biological;Biological Markers;Cancer Research Infrastructure;Childhood;chronic pain;chronic pancreatitis;Clinical Cancer Center;clinical center;Clinical Sciences;Clinical Trials;Collaborations;Collection;Complement;Cross-Sectional Studies;Data;Data Collection;Development;Diabetes Mellitus;diagnostic biomarker;Disease;Enrollment;Epidemiology;Evaluation;Exocrine pancreas;Exocrine pancreatic insufficiency;Fibrosis;follow-up;Fostering;Functional disorder;Funding;Future;Goals;Grant;Inflammation;Infrastructure;insight;Institution;Interdisciplinary Study;Lead;Leadership;Malignant neoplasm of pancreas;Malnutrition;Manuscripts;Medical Research;National Cancer Institute;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;novel;Observational Study;Ohio;organizational structure;Pancreas;participant enrollment;Patients;Positioning Attribute;predictive marker;Process;Progress Reports;Protocols documentation;Publications;repository;Research;Research Infrastructure;Research Personnel;response;Services;Tissues;Universities;working group

PROJECT_TITLE: The Ohio State University Chronic Pancreatitis Diabetes Pancreas Cancer (CPDPC) Clinical Center


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Project Narrative This project will address the neurobiological effects of novel surgical treatments for pediatric hydrocephalus. The successful completion of these studies will fill a critical void in hydrocephalus research and will provide evidence-based criteria for the clinical management of hydrocephalus.

PI_NAMEs: LIMBRICK, DAVID DELMAR;MCALLISTER, JAMES PATTERSON (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Ablation;absorption;Adolescent;Affect;Africa South of the Sahara;Aftercare;Anatomy;Animal Model;Animals;Autopsy;Axon;Behavior;behavioral outcome;Biology;Brain;Caring;Cauterize;Cell Death;Cells;Cephalic;Cerebral Ventricles;Cerebrospinal Fluid;Child;Childhood;Choroid Plexus Epithelium;Clinical;Clinical Management;clinical practice;clinically relevant;Cognition;Cognitive;cognitive testing;comparative;Complex;Creation of ventriculo-peritoneal shunt;Cytology;Cytopathology;Data;Development;Diffusion Magnetic Resonance Imaging;Domestic Pig;dysmyelination;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Epithelium;evidence base;Exhibits;experimental study;extracellular vesicles;Family suidae;Flow Cytometry;Fluid Balance;glial activation;Goals;Hemorrhage;Hippocampus;Hospital Charges;Human;Hydrocephalus;IL8 gene;Immune;immune activation;impaired brain development;Impaired cognition;Impairment;improved;indexing;Individual;Infant;Inflammation;Inflammatory;Injections;innovation;Interleukin-6;Intracranial Pressure;Kaolin;Knowledge;Length of Stay;Magnetic Resonance Imaging;Measures;Medical Device;Memory;Microglia;migration;Molecular;myelination;National Institute of Neurological Disorders and Stroke;NCAM1 gene;Nervous System Disorder;Neuroanatomy;neurobehavioral;Neurobiology;neurodevelopment;neurodevelopmental effect;neurogenesis;Neurologic;neurosurgery;novel;oligodendrocyte progenitor;Oligodendroglia;Operative Surgical Procedures;Organ;Outcome;Pediatric Hospitals;Physiological;Physiology;Pleocytosis;porcine model;premature;prenatal;primary outcome;Procedures;Proteins;Proteomics;Publishing;Research;Risk;Role;secondary analysis;Shunt Device;Signal Transduction;single-cell RNA sequencing;spectrograph;standard care;stem cells;Structure of choroid plexus;subventricular zone;Surgical Injuries;Techniques;Testing;Time;Tissues;tool;treatment effect;treatment group;United States National Institutes of Health;Ventricular;Ventriculostomy;white matter;Work

PROJECT_TITLE: Experimental Studies of Endoscopic Third Ventriculostomy and Choroid Plexus Cauterization in Hydrocephalus

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Precision Medicine

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Accumulating evidence indicate that a small subset of tumor cells readily adapt to different types of cellular stresses, including anticancer drugs, ultimately giving rise to tumors for which no effective treatments exist. Using different innovative technologies, this project aims to understand the mechanisms through which cancer cells escape treatment, and to develop approaches that reverse these adaptations, restrain the growth of resistant cells, and improve the outcomes of patients with colorectal cancer and other malignancies.

PI_NAMEs: ALONSO MARTINEZ, SALVADOR  (contact)

PROJECT_TERMS: Advisory Committees;anti-cancer research;Antineoplastic Agents;ATAC-seq;Automobile Driving;Award;Bar Codes;cancer cell;cancer therapy;Carcinoma;career;career development;Cells;Cellular Stress;Chemotherapy and/or radiation;Chromatin;Clinical;clinical translation;Clinical Trials;Colorectal Cancer;combinatorial;Computational Biology;Consensus;cytotoxic;Data;design;Development;Diagnosis;Drug resistance;effective therapy;environmental stressor;Epigenetic Process;epigenetic therapy;Event;exome;exome sequencing;exosome;experimental study;Exposure to;fitness;Fluorouracil;Genetic;Genetic Engineering;Genetic Transcription;Genotype;Goals;Growth;Immune response;improved outcome;Inflammatory;inhibitor;innovation;innovative technologies;knock-down;Knowledge;KRAS2 gene;Laboratories;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medicine;Mentors;Mentorship;Mesenchymal;metastatic colorectal;molecular dynamics;molecular subtypes;mouse model;Mutation;Neoadjuvant Therapy;neoplastic cell;non-genetic;Organoids;participant enrollment;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Phenotype;Population;Pre-Clinical Model;pressure;prevent;programs;Rectal Neoplasms;Refractory;Refractory Disease;regenerative;regenerative cell;Research;research and development;Research Personnel;Residual Neoplasm;Resistance;resistance mechanism;response;response biomarker;restraint;Risk;Role;Sampling;single cell technology;single-cell RNA sequencing;small hairpin RNA;small molecule inhibitor;stem cells;targeted treatment;Technology;Testing;Therapeutic;tissue regeneration;tool;transcriptome sequencing;Treatment Failure;treatment response;treatment strategy;tumor;Tumor Escape;Validation

PROJECT_TITLE: Targeting regenerative reprogramming in colorectal cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: MANHATTAN

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: Development and Validation of Pain in Food Animals  Project Narrative This project supports public health by contributing to the mechanisms for approval of new animal drugs, specifically analgesics for food animals, thereby lessening the risk of violative residues in the food supply from the use of unapproved drugs.

PI_NAMEs: APLEY, MICHAEL DOUGLAS (contact);MAZZARDO BORTOLUZZI, EDUARDA ;MESSENGER, KRISTEN ;PAIRIS-GARCIA, MONIQUE

PROJECT_TITLE: Development and validation of pain models in food animals

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CVM-T (07)]


FUNDING_MECHANISM: OTHERS

NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PI_NAMEs: DE BONO, BERNARD ;MARTONE, MARYANN E (contact)

PROGRAM_OFFICER_NAME: QASHU, FELICIA M

PROJECT_TERMS: 3-Dimensional;Anatomy;Autonomic nervous system;Bioinformatics;Data;data platform;Data Set;Enteric Nervous System;Knowledge;knowledge graph;Knowledge Management;Maps;Motor Pathways;Nervous System;Parasympathetic Nervous System;Resources;Semantics;Sensory;Services;simulation;Sympathetic Nervous System;technology development;tool

PROJECT_TITLE: K-CORE: Curation and Knowledge Management for SPARC


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: ZURICH

ORG_COUNTRY: SWITZERLAND

ORG_FIPS: SZ

ORG_NAME: IT'IS FOUNDATION

PI_NAMEs: KUSTER, NIELS  (contact)

PROJECT_TERMS: Anatomic Models;Anatomy;application programming interface;bioelectronics;Biophysics;Complex;Computer Analysis;Computer Models;computing resources;Coupling;Data;Data Analyses;data visualization;Dedications;deep neural network;design;Devices;Electromagnetics;Electrophysiology (science);Environment;Foundations;Goals;Image;image processing;Internet;interoperability;Knowledge Management;Maps;Medicine;Mission;Modeling;Organ;Peripheral;Peripheral Nervous System;Physiology;preservation;Program Accessibility;programs;Publishing;Reporter;Research Personnel;Resources;Running;Services;side effect;simulation;Spinal Cord;Therapeutic Effect;tool;Training;treatment planning;United States National Institutes of Health;user-friendly

PROJECT_TITLE: Open Platform for Online Simulations for Stimulating Peripheral Activity to Relieve Conditions - o2S2PARC

STUDY_SECTION: DCMM

STUDY_SECTION_NAME: Data Coordination, Mapping, and Modeling[DCMM(50)]


ORG_CITY: FAYETTEVILLE

ORG_NAME: DIVISION OF AGRICULTURE

ORG_STATE: AR

PHR: PROJECT NARRATIVE  Histomonas meleagridis is a unicellular parasite that causes severe morbidity and mortality in poultry populations, especially in turkeys, with mortality rates reaching 70-80%, but there are no drugs are available for preventing or treating histomonosis. Our research has revealed that H. meleagridis transitions into a cyst-like form, which serves as an intermediate stage to mediate infections among turkey poults, highlighting the potential of targeting the encystation pathway for innovative drug development to block parasite transmission. Our proposal aims to characterize the molecular mechanisms by which H. meleagridis parasites form cysts and transmit them between turkeys, to repurpose existing inhibitors used against other infectious diseases to mitigate histomonosis in turkey flocks, and to develop molecular genetic tools and generate transgenic H. meleagridis strains to advance research in this field.

PI_NAMEs: DOU, ZHICHENG ;GRAHAM, DANIELLE  (contact)

PROJECT_TITLE: Controlling Histomonas meleagridis transmission in turkey flocks


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative Gene editing has the potential to improve the resilience, health and productivity of animals raised for food and thus the sustainability of a safe and healthy food supply. We propose to establish an Innovation Center focused on intentional genomic alterations (IGA) to advance the use of gene editing technologies in food animals while contributing data to support a science-based regulatory approach to the regulation of IGAs. The information gained through this Cooperative Agreement will lead to the safe implementation of gene editing in animals raised for food to ensure animal health and productivity and thus food security and public health.

PI_NAMEs: BERGER, TRISH ;DENICOL, ANNA CAROLINA;MAGA, ELIZABETH A (contact);MUELLER, MACI ;RIGGS, PENNY K.;VAN EENENNAAM, ALISON L

PROJECT_TITLE: UC Davis IGA Innovation Center


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PI_NAMEs: ALLEN, MICHELE L (contact);HARDEMAN, RACHEL R;PATTEN, CHRISTI A

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TITLE: Center for Chronic Disease Reduction and Equity Promotion Across Minnesota (C2DREAM)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Lung;Rehabilitation;Telehealth

ORG_CITY: SPRINGFIELD

ORG_NAME: BAYSTATE MEDICAL CENTER, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE Chronic Obstructive Pulmonary Disease (COPD) affects approximately 16 million Americans, and is characterized by recurrent exacerbations that lead to 1.5 million Emergency Department visits and 700,000 hospitalizations annually. Pulmonary rehabilitation (PR) is a structured program of exercise and self- management support that has been proven to relieve shortness of breath and increase quality of life when initiated after an exacerbation, but unfortunately, few eligible patients participate. This project will compare the effectiveness of two novel strategies – one involving video narratives of other patients telling their story of how they overcame challenges and completed PR, the other involving telephonic peer coaching – to enhanced usual care, and to each other, at increasing patient participation in PR after an exacerbation.

PI_NAMEs: LINDENAUER, PETER KYLE (contact)

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: acute care;Adopted;Adult;Advisory Committees;Affect;American;arm;Attitude;Behavior;behavior change;Belief;blood pressure control;Chronic Disease;Chronic Obstructive Pulmonary Disease;Clinical;clinical outcome assessment;cohort;compare effectiveness;Consent;cost;deconditioning;Development;diabetes self-management;Disease Management;Dyspnea;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Eligibility Determination;Emergency department visit;Europe;exercise program;Expectancy;Goals;group intervention;Guidelines;Health;health literacy;health related quality of life;Health system;hospital readmission;Hospitalization;Hospitals;implementation outcomes;implementation strategy;improved;Individual;Infrastructure;Intervention;intervention effect;intervention refinement;Interview;Knowledge;Lead;Leadership;Libraries;Lived experience;Mediating;Methods;Modeling;mortality;motivational enhancement therapy;Narration;National Heart, Lung, and Blood Institute;novel strategies;Outcome;Patient Participation;Patients;peer;peer coaching;peer support;Phase;Physicians;Policies;prevent;Procedures;Professional Organizations;programs;Protocols documentation;pulmonary rehabilitation;Quality of life;Randomized;Recommendation;Recovery;recruit;Recurrence;Research;Self Efficacy;Self Management;Shortness of Breath;Social support;Structure;Surveys;Techniques;Telephone;Testing;Training;Transportation;treatment as usual;United States;uptake;Visit

PROJECT_TITLE: Improving Participation in Pulmonary Rehabilitation through Peer-Support and Storytelling


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Natural Products

ORG_CITY: SAN ANTONIO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: Narrative This project will investigate the chemistries of a group of enzymes involved in the biosynthesis of crucial building blocks of natural products with antibiotic and anticancer properties. The biochemistry of secondary metabolism learned from this study will deepen the understanding of synthetic pathways and regulation toward bioactive molecules. The knowledge procured will also help design and expand the repertoire of chemical compounds with desired biological activities beneficial for human health.

PI_NAMEs: LIU, AIMIN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TITLE: Heme-Dependent Chemistry in Aromatic Oxidation


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Telehealth

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Traditional lifestyle interventions involve numerous visits for months which is not practical for many people. The proposed randomized trial will compare two telehealth lifestyle interventions, one that is delivered via videoconference meetings and one that is delivered asynchronously in a private Facebook group. Findings will provide evidence for two forms of telehealth-delivered lifestyle interventions.

PI_NAMEs: PAGOTO, SHERRY L. (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Address;arm;behavioral health;Body Weight decreased;comparison intervention;Computer software;cost;effective intervention;efficacious intervention;experience;Facebook;Human;interest;Intervention;Lead;lifestyle intervention;Maintenance;meetings;mobile application;Modeling;Outcome;Participant;patient engagement;Patients;peer;Persons;Phase;Policies;Privatization;Randomized;randomized trial;Randomized, Controlled Trials;remote delivery;remote group;remote health care;remote intervention;Research;scale up;Schedule;secondary outcome;synchronous delivery;systematic review;Teleconferences;telehealth;Telephone;Testing;Text;Time;trial comparing;videoconference;Videoconferencing;Visit;Weight;Work

PROJECT_TITLE: A non-inferiority trial comparing synchronous and asynchronous remotely-delivered lifestyle interventions

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Machine Learning and Artificial Intelligence;Nanotechnology;Orphan Drug;Rare Diseases

ORG_NAME: UBIQUITX, INC.

PHR: NARRATIVE UbiquiTx is pioneering a new class of computationally-designed mRNA therapeutics that encode peptide-guided protein degraders, known as ubiquibodies (uAbs), for potent and selective degradation of historically undruggable targets not addressable by conventional drugs. To further advance our platform, this Phase I STTR project seeks to design customized uAbs against β-catenin and CCAAT/enhancer-binding protein homologous protein (CHOP), two intracellular transcription factors that hold promise as drug targets for hepatocellular carcinoma (HCC), alpha-1 antitrypsin deficiency (AATD), and other liver diseases. By accelerating the removal of these two key intracellular disease drivers through LNP-mediated delivery of mRNA encoding peptide-guided uAbs, these studies will provide important proof-of-concept for our unconventional approach to drugging the proteome.

PI_NAMEs: CAMARGO, LUIZ MIGUEL QUINN (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Acceleration;Address;Advanced Development;alpha 1-Antitrypsin Deficiency;Animal Model;Area;Artificial Intelligence;beta catenin;Binding;Biodistribution;Biological;CCAAT-Enhancer-Binding Proteins;Cells;Chimera organism;commercialization;Cultured Cells;design;Development;Disease;drug development;drug discovery;Drug Targeting;Ectopic Expression;Evaluation;Excision;Formulation;Future;Genetic Engineering;Homologous Protein;Human Genome;innovation;interest;lipid nanoparticle;liver cancer model;Liver diseases;Machine Learning;Mediating;Messenger RNA;Modernization;mRNA delivery;multicatalytic endopeptidase complex;Mus;new technology;novel strategies;Nuclear;Pathway interactions;Peptides;Pharmaceutical Preparations;pharmacologic;Phase;Polyubiquitination;Primary carcinoma of the liver cells;protein degradation;Proteins;Proteome;proteotoxicity;Small Business Technology Transfer Research;Technology;Therapeutic;therapeutic candidate;Toxic effect;transcription factor;tumorigenic;Ubiquitin;ubiquitin-protein ligase

PROJECT_TITLE: Computational design and evaluation of peptide-guided protein degraders


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Eye Disease and Disorders of Vision;Genetics;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: Project Narrative Cadmium is a near ubiquitous food contaminant that the general (non-occupational, non-smoking) population ingests at higher levels than the WHO determined provisional tolerable weekly intake. Cadmium is associated with impaired vision, learning challenges and behavioral disorders, with possible cascading effects on future generations. This proposal examines how cadmium exposure insults vision and genetic profiles leading to negative effects on learning, memory, and behavior in juveniles and across generations using zebrafish (Danio rerio) as a model, which supports NIEHS new initiative on Environmental Risks for Psychiatric Disorders.

PI_NAMEs: SHELTON, DELIA S (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Ablation;Achievement;Adolescent;Adverse effects;Advisory Committees;Affect;age related;Animals;antisocial behavior;Architecture;Area;Behavior;Behavior Disorders;Behavioral;Behavioral Assay;behavioral impairment;Behavioral Paradigm;Bioinformatics;bioinformatics tool;Biological;Biological Assay;Biological Markers;Brain;burden of illness;Cadmium;career;Cells;Central Nervous System;Cessation of life;Chemicals;Chronic;Cognitive;Complement;cost;Data;Defect;design;Development;dietary;Dietary Cadmium;disability;Disease;Disruptive Behavior Disorder;Early Intervention;Ecology;Electrophysiology (science);Environment;Environmental Exposure;Environmental Risk Factor;environmental stressor;Epidemiology;Epigenetic Process;Etiology;Exposure to;Food;Future Generations;Gene Expression;Gene Expression Profiling;Generations;Genetic;Goals;Half-Life;Health;Heavy Metals;high throughput screening;Human;imaging modality;Immunohistochemistry;Impairment;improved;in vivo;Inductively Coupled Plasma Mass Spectrometry;Ingestion;insight;Instruction;Intake;intergenerational;Intervention;Investigation;Knowledge;laser capture microdissection;Lasers;late life;Learning;Learning Disabilities;Life;Link;Memory;Mental disorders;Mentors;Methods;Modeling;Modernization;Molecular;Molecular Toxicology;National Institute of Environmental Health Sciences;Nervous System Physiology;neural;neurocognitive disorder;neuropathology;neurophysiology;Neuropsychology;Neurosciences;neurotoxicity;non-smoking;novel;Ocular Physiology;Outcome;Pathology;Pathway interactions;Perception;Phase;Physiological;Policies;pollutant;Pollution;Population;Positioning Attribute;premature;Prevention;Public Health;Research;Research Design;Research Personnel;Resources;response;Retina;Rodent;Role;screening;Sensory;sensory mechanism;skills;social;Social Behavior;Social Development;social influence;superior colliculus Corpora quadrigemina;symposium;System;Systems Biology;Techniques;Technology;Testing;Tissues;Toxic effect;Toxicology;Training;transcriptome sequencing;Transgenic Organisms;Vision;Visual;Visual impairment;visual motor;Visual System;Water;Work;Zebrafish

PROJECT_TITLE: Sensory Mechanisms of Cadmium-Induced Behavioral Disorders Across Generations


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATHENS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Narrative: This proposed 4-series Conference is highly relevant to public health issues related to Alzheimer's disease and related dementias (ADRD). The series will serve as a forum to bring together an interdisciplinary group of clinicians, scientists and the community to develop a population disease framework related to unique factors related to the susceptibility of minority populations to ADRD. Focus will include genetic, environmental, lifestyle and sociodemographic factors will the goal of understanding how genetic factors interact with these other factors to enhance risk of ADRD within and between minorities.

PI_NAMEs: RICHARDSON, JASON R (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Address;Affect;African American population;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Attention;Basic Science;Brain;Calibration;Clinical Research;Clinical Trials;Communication;Communities;comorbidity;Dedications;dementia risk;Demographic Factors;Development;Device or Instrument Development;Diabetes Mellitus;Diet;Disease;Education;Enrollment;Environmental Exposure;Epidemiology;Epigenetic Process;ethnic minority;Ethnic Origin;Ethnic Population;Family;Florida;gene environment interaction;Genes;Genetic;Genetic Risk;Goals;Health;Health Disparities Research;health disparity;high risk;Hormonal;improved;Income;Individual;Inequity;innovation;instrument;Interdisciplinary Study;International;Knowledge;Late Onset Alzheimer Disease;Latino Population;life span;Life Style;lifestyle factors;lifetime risk;Measurement;Mediating;Mental Health;Metabolic;Methods;Minority;Minority Groups;Minority Women;model development;Modeling;Modification;Morbidity - disease rate;Neurodegenerative Disorders;Neurosciences;Nonpharmacologic Therapy;Occupational;Paper;Pathology;Pathway interactions;Patients;Peer Review;pharmacologic;Population;precision medicine;Predisposition;Process;programs;Public Health;Publications;Race;Recording of previous events;Reporting;Research;Respondent;Rest;Risk;risk mitigation;Science;Scientist;Series;sex;Sex Differences;social;social factors;sociodemographic factors;symposium;Theoretical model;theories;Therapeutic Intervention;therapy development;Time;Toxicant exposure;Training;Translational Research;Underrepresented Populations;United States;Universities;Vascular Diseases;Woman;Work

PROJECT_TITLE: Health Disparities in Alzheimers and Related Diseases


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Lung;Networking and Information Technology R&D (NITRD);Pulmonary Fibrosis;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE  Idiopathic Pulmonary Fibrosis (IPF) is a chronic progressive lung disease with significant morbidity and mortality. The overall objective of this application is to apply the principles of systems biology to create, refine and validate a cell specific causal model of IPF emergence and progression in the human lung and thus transform our ability to design effective interventions.

PI_NAMEs: BENOS, PANAGIOTIS V;KAMINSKI, NAFTALI  (contact)

PROGRAM_OFFICER_NAME: GAN, WEINIU

PROJECT_TERMS: Address;Affect;allograft rejection;Alveolar;Animal Model;Architecture;Bioinformatics;Biomedical Engineering;Blood Vessels;causal model;Cell Aggregation;cell injury;Cell Nucleus;Cells;Cellular biology;Cellular Infiltration;Chronic;Collagen;Computational Biology;computer science;Computing Methodologies;Connective Tissue Diseases;Data;data dissemination;data sharing;Deposition;design;Development;Disease;Distal;effective intervention;Epithelial Cells;experimental study;Extracellular Matrix;FDA approved;Fibrosis;fibrotic interstitial lung disease;Foundations;Gene Expression;Generations;Genes;Genetic Predisposition to Disease;Genetic Transcription;Genomics;Grant;Heterogeneity;Histologic;Histology;Human;human model;idiopathic pulmonary fibrosis;Image;Immune;Immunity;insight;Intervention;Lung;lung allograft;Lung Diseases;Machine Learning;Maps;member;Metadata;Methods;microCT;miRNA expression profiling;Modeling;Molecular;Molecular Biology;Molecular Target;Morbidity - disease rate;mortality;multidisciplinary;Multiomic Data;Myofibroblast;novel;Pathology;Patients;Persons;Pharmaceutical Preparations;Phenotype;Population;pre-clinical;predictive modeling;Process;Proteomics;Pulmonary Fibrosis;Pulmonary Inflammation;repaired;Resolution;Sampling;Severities;Signal Transduction;single cell technology;statistics;Systems Biology;Techniques;Technology;Therapeutic Intervention;tissue resource;Tissues;tool;transcriptome;transcriptome sequencing;Usual Interstitial Pneumonia;Validation;Work

PROJECT_TITLE: Genomic Analysis of Tissue and Cellular Heterogeneity in IPF

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-G(03)]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative For the brain to function it is essential that large numbers of neurons are interconnected in a highly precise manner, a process which is controlled by the patterns of genes expressed during brain development. Work of this grant focuses on a circuit of the Drosophila brain controlling navigation. We are analyzing connectivity within this circuit with digital connectomes, and use optogenetic tools to record and manipulate neuronal activity in order to develop concepts which are important to understand, and therapeutically manipulate, circuits formed by nerve cells in the human brain.

PI_NAMEs: HARTENSTEIN, VOLKER  (contact);LOUIS, MATTHIEU R. P. J. C. G.

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TITLE: Developmental and functional analysis of neural circuits controlling navigation in Drosophila

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Lung;Lung Cancer;Pancreatic Cancer;Rare Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

PHR: PROJECT NARRATIVE Molecular drivers and cellular interactions drive changes in cancer cell state that contribute to tumor growth and progression, but how these factors coordinatively drive tumorigenesis is not well defined. I propose to elucidate mechanisms of chromatin regulation and evasion of immune response by using innovative mouse models and functional genomics analyses. This work will provide novel insight into the principles of chromatin regulation and tumor heterogeneity that contribute to progression in lung and pancreas cancers, which may also be applicable to other cancer types.

PI_NAMEs: ASHKIN, EMILY LORIN (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: 3-Dimensional;anti-tumor immune response;Antigens;Architecture;Bar Codes;Biological Assay;Biological Process;cancer cell;cancer type;candidate identification;cell type;Cells;Cellular Immunity;Characteristics;chemotherapy;Chromatin;Chromatin Loop;Chromosome Mapping;Cleavage Under Targets and Release Using Nuclease;cohesin;Complex;Cytotoxic T-Lymphocytes;Data;Dedications;Dependence;Development;Diagnosis;Disease Progression;Evolution;experience;experimental study;functional genomics;Gene Expression;Gene Expression Profile;Gene Expression Profiling;gene function;Genes;Genetic;Genetically Engineered Mouse;Goals;high throughput screening;Immune Evasion;Immune response;Immunophenotyping;immunoregulation;in vivo;innovation;insight;KRAS oncogenesis;KRAS2 gene;Laboratories;Lung;lung cancer cell;Lung Neoplasms;lung tumorigenesis;Maintenance;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Mediating;Mediator;medical specialties;Mentors;Methodology;Molecular;Molecular Conformation;mouse model;multidisciplinary;multiple omics;Mus;neoplastic cell;novel;novel strategies;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Phase;Play;Positioning Attribute;Postdoctoral Fellow;Proteins;Regulation;Research;Research Project Grants;response;Role;Shapes;System;T cell response;T-Lymphocyte;Techniques;Time;Training;tumor;tumor growth;tumor heterogeneity;Tumor Immunity;tumor immunology;tumor progression;Tumor stage;Tumor Subtype;Tumor Suppression;Tumor Suppressor Genes;Tumor Suppressor Proteins;Tumor Volume;tumorigenesis;Work

PROJECT_TITLE: Chromatin and immune regulation of tumor growth and progression


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: This proposal is to establish the Northern Pacific Global Health Leadership, Education, And Development for Early-career Researchers (NPGH LEADERs) Consortium – a research training program directed by the University of Washington in partnership with the Universities of Hawaii, Michigan and Minnesota with international partnerships in Cameroon, Ghana, India, Kenya, Liberia, Nepal, Peru, Thailand, and Uganda. The goal of this Consortium is to provide outstanding mentored research training to U.S. and LMIC post-doctoral and U.S. pre-doctoral trainees at international partner institutions in order to create the next generation of independent global health scientists and leaders.

PI_NAMEs: DATTA, DIBYADYUTI ;JOHN, CHANDY C.;MOYER, CHERYL A.;PRASAD, SHAILENDRA ;ZUNT, JOSEPH RAYMOND (contact)

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TITLE: NPGH LEADERs - ODP - Thiyagarajan


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative: The singular goal of most spinal cord injury (SCI) research programs is to repair the injured spinal cord and restore locomotor function. Unfortunately, restoration of walking is a low priority for most SCI individuals. In addition to impaired mobility, SCI causes slow and steady pathological changes in organ systems throughout the body. Failure to recognize and treat multi-organ system pathology as a standard of care may explain why survival rates have not improved for SCI patients (relative to able-bodied individuals) over the past 30 years. Experiments in this proposal are designed to study SCI as a disease of the entire body and will yield novel data that will ultimately promote recovery of function and quality of life (QoL) after SCI.

PI_NAMEs: POPOVICH, PHILLIP G (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Body System;Data;design;Disease;experimental study;Failure;Goals;Individual;Inflammation;injury and repair;Mobility decline;novel;parent grant;Pathologic;Pathology;programs;Quality of life;Recovery;Recovery of Function;Research;restoration;Spinal cord injury;Spinal cord injury patients;standard of care;Survival Rate;Walking

PROJECT_TITLE: Overcoming Neurogenic “Meta-Inflammation” to Promote Recovery After Spinal Cord Injury


ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Mitochondria are the site of essential cellular processes such as metabolism and apoptosis (controlled cell death), which are often misregulated in cancer and neurodegenerative diseases. Proper mitochondrial function depends on a robust quality control system to remove old, damaged, or mislocalized proteins. Here, I propose experiments to test how mitochondrial protein quality control systems function, which could lead to new therapeutic approaches to cancer and neurodegenerative diseases.

PI_NAMEs: WOHLEVER, MATTHEW LEE (contact)

PROJECT_TERMS: Affect;Aging;Apoptosis;Apoptotic;ATP Hydrolysis;ATP phosphohydrolase;Biological Assay;Biology;Cardiovascular Diseases;Cell Death;Cell Physiology;Cessation of life;conditioned fear;Encephalopathies;Excision;experimental study;Genetic;Health;Homeostasis;Homologous Gene;Human;Impairment;In Vitro;insight;Investigation;Lead;Link;Lipid Bilayers;Malignant Neoplasms;Mediating;Membrane;Membrane Fluidity;Membrane Proteins;Metabolism;Mitochondria;mitochondrial membrane;Mitochondrial Proteins;Molecular;Mutation;Neurodegenerative Disorders;novel therapeutic intervention;Outer Mitochondrial Membrane;Oxidative Phosphorylation;Physiological;Play;Process;Proteins;Proteome;Proteomics;proteostasis;Quality Control;reconstitution;Regulation;Role;Site;Structure;System;Testing;Universities;Utah;Work

PROJECT_TITLE: Mechanistic Investigation of Proteostasis at the Outer Mitochondrial Membrane

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Diabetes;Neurodegenerative;Neurosciences;Nutrition;Physical Activity;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: The DPPOS AD/ADRD project will address the overarching question: What are the determinants and the nature of cognitive impairment among persons with pre-diabetes (PreD) and type 2 diabetes (T2D), who are a high-risk group for cognitive impairment and represent a large fraction of the United States (US) population? This U19 proposal addresses the National Alzheimer’s Project Act goal to “prevent, halt, or reverse AD” in the high-risk group of persons with pre-diabetes and type 2 diabetes, who represent over half of the population aged 60 years and older in the US.

PI_NAMEs: LUCHSINGER, JOSE ALEJANDRO (contact);NATHAN, DAVID M;TEMPROSA, MARINELLA

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Acceleration;Address;adjudication;Age;aged;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid;amyloid imaging;Behavioral;biobank;Biological Markers;Biometry;Blood Vessels;Brain;Brain imaging;Cerebrovascular Disorders;Clinical;Cognition Disorders;cognitive testing;cohort;Cohort Studies;Complex;data infrastructure;data management;Data Set;Dementia;dementia risk;Development;diabetes prevention program;ethnic minority;Exposure to;extracellular vesicles;frailty;Funding;Glucose;Goals;high risk;high risk population;human old age (65+);Hyperinsulinism;Impaired cognition;insulin signaling;Knowledge;Lead;life span;Life Style;macrovascular disease;Magnetic Resonance Imaging;Measurement;Measures;Metabolic;Metformin;mild cognitive impairment;Nature;Nerve Degeneration;neuroimaging;neuroinflammation;Neurons;neuropathology;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Observational Study;operation;Outcome Study;Participant;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Physical activity;Physical Function;Placebos;Plasma;Population;Positron-Emission Tomography;Prediabetes syndrome;prevent;Procedures;racial minority;Randomized Controlled Clinical Trials;Reading;Research;Role;Sampling;segregation;Site;sociodemographics;tau Proteins;Time;United States;vascular cognitive impairment and dementia;Woman

PROJECT_TITLE: Alzheimer's Disease and Alzheimer's Disease Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD Project


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Most behavioral weight-loss interventions have had mixed outcomes, with interventions failing to make a substantial or persistent difference in racial/ethnic minority populations. This may be secondary to neglecting the influence of an individual’s social environment. The results of this feasibility randomized control trial will result in a multi-level intervention that targets individual and network-level barriers to weight loss.

PI_NAMEs: PHILLIPS, ERICA  (contact)

PROJECT_TERMS: Address;Adoption;Adult;adult obesity;Affect;arm;Asian population;Behavior;behavior change;Behavioral;Black race;black women;Body mass index;Body Weight Changes;Body Weight decreased;Characteristics;Clinical;Clinical Trials;commune;Communication;comparison control;Control Groups;coping;Data;design;Diabetes Mellitus;Diet;Diffusion;Disease;Educational process of instructing;Enrollment;Environmental Risk Factor;ethnic minority;ethnic minority population;Ethnic Population;experience;Failure;Family;Feasibility Studies;Friends;Glycosylated hemoglobin A;Goals;good diet;Health;Health behavior;Healthy Eating;high risk;high risk population;Hispanic;Home;improved;Individual;Insulin Resistance;interpersonal conflict;Intervention;intervention effect;Intervention Studies;Knowledge;Life Style;lifestyle intervention;Link;Literature;Measurement;Measures;member;Metabolic;Mission;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;neglect;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Obesity;obesity risk;obesity treatment;Outcome;Participant;Pattern;Persons;Phenotype;Physical activity;Population;prevent;primary outcome;Process;promote resilience;prospective;Race;racial difference;racial minority;racial minority population;Randomized;Randomized, Controlled Trials;recruit;Recurrence;response;Risk;Secondary to;social;Social Environment;social factors;Social Network;social norm;Social support;Structure;Testing;Thinking;Time;Weight;Weight Gain;weight loss intervention

PROJECT_TITLE: Reducing Obesity Using Social Ties (ROBUST)


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Neurosciences;Opioids;Pain Research;Patient Safety;Physical Rehabilitation;Prevention;Primary Health Care;Rehabilitation;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: BALTIMORE

ORG_DEPT: ORTHOPEDICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Physical therapy is the first line of treatment for patients with low back pain (LBP) and has been shown to be a cost-effective method for improving pain and disability in patients with chronic LBP; however, despite this effectiveness, only 7-13% of patients go on to receive physical therapy services with patients in rural communities being especially limited to do lack of provider availability, transportation, and missed work time leading to greater rates of LBP-related disability and opioid consumption. With the rapid emergence of digital treatment approaches to physical therapy (i.e., telerehabilitation), access could be improved by reducing or eliminating many barriers that patients report; however, it is unclear how to appropriately incorporate digital treatment approaches into existing health care models. We propose a single-masked prospective randomized clinical trial conducted at a health system serving rural communities to determine the effectiveness of innovative risk-stratified telerehabilitation versus standard educational control for patients with chronic LBP that will match individual patients with specific physical therapy delivery (remote therapeutic monitoring; physical therapy telehealth visits; or psychologically informed physical therapy telehealth visits) based on their psychosocial risk of poor outcomes.

PI_NAMEs: MCLAUGHLIN, KEVIN ;SKOLASKY, RICHARD L. (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Absenteeism at work;academic standard;Acceleration;Address;Adoption;Affect;Area;barrier to care;Caring;Chronic disability;Chronic low back pain;clinical practice;Clinical Research;Clinical Trials;clinically relevant;collaboratory;Community Healthcare;compare effectiveness;Conduct Clinical Trials;Consumption;cost;cost effective;COVID-19 pandemic;Data;Data Analyses;Data Collection;Diagnosis;digital treatment;disability;Disability scale;Disparity;Education;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness/implementation hybrid;electronic health data;Electronic Health Record;electronic health record system;Electronics;Eligibility Determination;Enrollment;experience;functional improvement;Gender;health care model;health care service utilization;health related quality of life;Health system;Healthcare;Healthcare Systems;Heterogeneity;high risk;Image;implementation outcomes;implementation strategy;Improve Access;improved;improved outcome;Individual;individual patient;Information Systems;Informed Consent;Injections;innovation;Institution;Intervention;Interview;Length;Low Back Pain;Maryland;Masks;Measures;Methods;metropolitan;mobile application;Monitor;Office Visits;Operative Surgical Procedures;opioid use;Outcome;Outcome Measure;outpatient programs;Pain;pain-related disability;Patient Outcomes Assessments;Patient-Focused Outcomes;patient-level barriers;Patients;Phase;physical conditioning;Physical Function;physical therapist;Physical therapy;Policies;pragmatic trial;prescription opioid;Prevalence;primary care clinic;Process;programs;prospective;Protocols documentation;Provider;psychologic;psychosocial;Randomized;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;remote health care;Reporting;Research;Risk;risk stratification;Rural;Rural Community;rural healthcare;Sample Size;secondary outcome;Services;Single-Blind Study;Site;Societies;Structure;Surveys;telehealth;telerehabilitation;Therapeutic;Time;Translating;Translations;Transportation;Travel;treatment as usual;treatment effect;Treatment Protocols;trial comparing;trial design;United States;United States National Institutes of Health;Visit

PROJECT_TITLE: Improving Function and Reducing Opioid Use for Patients with Chronic Low Back Pain in Rural Communities through Improved Access to Physical Therapy using Telerehabilitation


ACTIVITY: ZIA

ADMINISTERING_IC: CL

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: CLINICAL CENTER

ORG_NAME: CLINICAL CENTER

PI_NAMEs: MASUR, HENRY  (contact)

PROJECT_TERMS: anti-hepatitis C;Chronic;Chronic Hepatitis B;Clinical Protocols;Clinical Trials;Code;Combined Modality Therapy;Consent;Data;Hepatitis B Virus;Hepatitis C;Hepatitis C virus;HIV;human subject protection;Idiopathic CD4-Positive T-Lymphocytopenia;Immunologic Factors;Immunology;immunoregulation;Infectious Diseases Research;Institutional Review Boards;Laboratories;Laboratory Research;Manuscripts;National Institute of Allergy and Infectious Disease;Pathogenesis;Patients;Pilot Projects;Protocols documentation;Reporting;Research;research clinical testing;Research Personnel;Resources;Safety;Sampling;Serum;Specimen;United States National Institutes of Health

PROJECT_TITLE: Analysis of Stored Samples Collected Using Previously Expired Protocols


PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;alcohol use disorder;Behavior;Blood;clinical center;Collaborations;comorbidity;Consultations;COVID-19 outbreak;craving;Cytochrome P450;design;Development;Dopamine;Enrollment;Follow-Up Studies;Goals;Hepatotoxicity;high risk behavior;HIV;HIV/HCV;Human;Individual;inhibitor;Longterm Follow-up;Metabolism;Methadone;Midazolam;National Institute of Allergy and Infectious Disease;National Institute of Drug Abuse;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National Institute on Alcohol Abuse and Alcoholism;Needle Sharing;novel;opioid use disorder;pathogen;Pathway interactions;Patient-Focused Outcomes;Pharmaceutical Preparations;Phase;phase 1 study;phase 2 study;Research Personnel;Stimulus;Substance of Abuse;Substance Use Disorder;Toxic effect;Transaminases;transmission process;United States National Institutes of Health;Ventilatory Depression;volunteer;Washington;Woman

PROJECT_TITLE: Reducing the Impact of Opioid Use Disorder on the Acquisition and Management of HIV and on Comorbidities (SEARCH)


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Microbiome

PI_NAMEs: MUALLEM, SHMUEL  (contact)

PROJECT_TERMS: Acinar Cell;Acinus organ component;Affect;anoctamin 5;Bicarbonates;Binding Proteins;Biological;Buffers;Cell membrane;Cell Nucleus;Cell Physiology;Cells;chronic pancreatitis;Complex;Cyclic AMP;Cystic Fibrosis Transmembrane Conductance Regulator;Cytoplasm;Cytoplasmic Granules;Disease;disease phenotype;Duct (organ) structure;Endowment;Enzymes;Epithelium;Exocrine Glands;Exocytosis;Fluids and Secretions;Future;G-Protein-Coupled Receptors;Gatekeeping;Gene Expression Regulation;Genetic;Gland;gut microbiome;Hydrolysis;improved;Inflammatory;lipid metabolism;Lipids;Liquid substance;macromolecule;Mediating;Mediator;Membrane;microbiome;Minor salivary gland structure;Molecular;mouse model;Mucins;NAADP;nano;novel;nuclear factors of activated T-cells;Oral cavity;Organelles;Pancreas;pancreatic juice;Pancreatitis;Pathology;Patients;Pattern;Permeability;Ph+ ALL;pharmacologic;Phosphatidylserines;Physiological;premature;prevent;Property;Proteins;Pump;receptor;Regulation;repaired;Research;Rest;Role;Saliva;saliva secretion;Salivary Glands;Scaffolding Protein;Secretory Cell;Secretory Vesicles;Signal Pathway;Signal Transduction;Site;Sjogren's Syndrome;Solubility;STIM1 gene;symporter;synergism;Testing;Time;Tissues;Toxic effect;VAPA gene;virtual;Work;Zymogen Granules

PROJECT_TITLE: Ca2+ signaling and HCO3- secretion by exocrine glands


NIH_SPENDING_CATS: Breast Cancer;Cancer;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Physical Activity;Prevention;Women's Health Research

ORG_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

PI_NAMEs: BERRUETA, LISBETH  (contact)

PROJECT_TERMS: Aerobic Exercise;Anesthesia procedures;Animal Behavior;Animal Model;Animals;Area;Attention;Benign;Biological Markers;Breast Cancer cell line;Breast Cancer Model;Cadherins;Cancer Model;Cancer Patient;cancer type;CASP3 gene;Cell Line;cell motility;Collagen;Collagen Fiber;Connective Tissue;Crowns;Data;Estrogen Receptors;Exercise;Extracellular Matrix;Fiber;Fibrosis;Flow Cytometry;Food;FVB Mouse;Gel;Genes;Health;Home;Human;Image;Implant;improved mobility;in vitro Model;in vivo Model;Inflammation;Inflammatory Response;interest;Malignant Neoplasms;Mammary Neoplasms;Measures;Mechanics;Mediator;Metastatic Neoplasm to the Lung;Modality;Modeling;Monitor;Mouse Mammary Tumor Virus;Movement;Mus;Neoplasm Metastasis;Nonpharmacologic Therapy;Personal Satisfaction;Photons;Physical activity;Plasmids;polyoma middle tumor antigen;Polyomavirus;Primary Cancer Prevention;Production;Progesterone Receptors;Qi Gong;Randomized;Resolution;Rheology;Rodent Model;second harmonic;Secondary Cancer Prevention;single-cell RNA sequencing;spheroids;Stretching;Structure;Supine Position;symptom management;System;Tai Ji;Techniques;Testing;three dimensional cell culture;Tissues;Transgenes;Transgenic Model;translational potential;tumor;tumor growth;tumor progression;Tumor-Associated Process;Visualization;Water;X-Ray Computed Tomography;Yoga

PROJECT_TITLE: Impact of Stretching on Tumor growth and Metastasis