NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Congenital Structural Anomalies;Digestive Diseases;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

PHR: The role of macrophages in hepatobiliary development Narrative In the proposed work, we will employ macrophage-deficient zebrafish and transgenic reporter strains combined with high-resolution confocal imaging and novel image analysis methods to determine the importance of macrophages for liver development. We will determine the requirement for macrophages for biliary tree branching morphogenesis and hepatocyte polarization, and the role of TNFα and TGFβ signaling in attracting macrophages and mediating their effects. The proposed work will further elucidate our understanding of developmental defects of biliary tree formation.

PI_NAMEs: GOESSLING, WOLFRAM  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Ablation;Affect;Alagille Syndrome;Anatomy;Antigens;Architecture;Area;bile duct;Bile fluid;Biliary;Biliary Atresia;biliary tract;Cells;chemical genetics;Child;Childhood;confocal imaging;Cues;Defect;Development;Developmental Process;Differentiation and Growth;Disease;Drug Metabolic Detoxication;Embryo;Embryonic Development;Exhibits;experimental study;Exposure to;Extrahepatic;Fishes;Genetic;genetic approach;Goals;Growth;Health;hematopoietic stem cell formation;Hepatobiliary;Hepatocyte;Homeostasis;Image Analysis;Immune;Immune response;Immunity;Impairment;in utero;in vivo;in vivo imaging;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;innovation;insight;Kupffer Cells;Liver;liver development;Liver diseases;liver function;liver transplantation;Location;Macrophage;Mediating;Metabolic;Methods;Microbe;microbial products;Microscopy;Molecular;Morphogenesis;mutant;Natural regeneration;notch protein;novel;nutrient metabolism;Obstruction;Organ;Outcome;Pathogenesis;Play;Population;Production;quantitative imaging;Reporter;Reporter Genes;Resolution;Role;Serum Proteins;Shapes;Signal Pathway;Signal Transduction;Source;spatiotemporal;TNF gene;Toxin;Transforming Growth Factor beta;Transgenic Mice;Transgenic Organisms;Work;wound healing;Yolk Sac;Zebrafish

PROJECT_TITLE: The Role of Macrophages in Hepatobiliary Development

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Despite decades of basic research and therapeutic development, p53 mutant proteins remain undruggable due to the lack of enzymatic activity and intracellular localization. There is a critical gap between existing mouse models and the translational research targeting mutant p53 in the era of immunotherapy. We will use the optimized syngeneic mouse models to develop precision cancer therapeutics against the top hotspot p53 mutants in immunocompetent systems.

PI_NAMEs: LI, YONG  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Address;Allografting;Amino Acids;anti-cancer research;Antibodies;Antigen Presentation;antigen-specific T cells;Antigens;Arsenic;autosome;B-Lymphocytes;Basic Science;Biological Models;Bispecific Antibodies;Bispecific Monoclonal Antibodies;cancer care;cancer initiation;Cancer Patient;cancer therapy;cancer type;Carcinogens;Cell surface;Cells;cellular targeting;Clinical;Clinical Trials;Code;Credentialing;Cultured Tumor Cells;Data;Development;DNA Binding Domain;DNA Vaccines;drug development;Drug Targeting;Engraftment;Environment;Environmental Carcinogens;Exhibits;Experimental Models;Family;Frequencies;Genes;Genetic;Genetic Engineering;Germ Lines;Hereditary Disease;Human;Human Cell Line;Human Genome;immune checkpoint blockade;Immune response;Immune system;Immunocompetent;immunodeficiency;Immunotherapeutic agent;Immunotherapy;improved;Infiltration;Inherited;inhibiting antibody;Li-Fraumeni Syndrome;Major Histocompatibility Complex;Malignant Neoplasms;Mediating;Missense Mutation;Modeling;Monoclonal Antibodies;Mouse Cell Line;mouse model;Mouse Strains;Mus;mutant;Mutate;Mutation;Natural Immunity;neoantigens;neoplasm immunotherapy;neoplastic cell;novel;novel strategies;Oncogene Activation;Oncogenic;patient derived xenograft model;Patients;Penetrance;Performance;Phosphoric Monoester Hydrolases;Physiologic pulse;Plasma Cells;Precision cancer therapy;precision medicine;precision oncology;Predisposition;prevent;Prognosis;programs;Property;Proteins;Research;research and development;response;Role;Serum;small molecule;Somatic Mutation;stressor;Supporting Cell;System;T cell response;T-Cell Receptor;T-Lymphocyte;targeted agent;Targeted Research;Testing;Therapeutic;therapeutic development;Tissues;TP53 gene;Traction;transcription factor;Translational Research;tumor;Tumor Antigens;Tumor Cell Line;tumor progression;Tumor Suppression;Tumor Suppressor Genes;Tumor Tissue;tumorigenesis;United States Food and Drug Administration;Vaccines;vector;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Optimizing Syngeneic Mouse Models to Target Mutant p53

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-B(55)R]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: Newark

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: NARRATIVE Our studies will reveal how immune receptors recognize and respond to viral infections; understanding their fundamental biochemical properties will pave ways to develop new antivirals, vaccine adjuvants, immune activators. Our research will provide the mechanisms of enzymes that transcribe and replicate the human mitochondrial DNA whose maintenance is vital for energy production. This foundational knowledge will provide the basis to discover treatments for mitochondrial related diseases caused by malfunctions of these enzymes.

PI_NAMEs: PATEL, SMITA S (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Anti-viral Agents;ATP phosphohydrolase;Bacteriophage T7;Binding Proteins;Biochemical;Biochemical Reaction;Biological Assay;biophysical techniques;Coupled;Cryoelectron Microscopy;Defect;Development;Disease;DNA;DNA biosynthesis;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;enzyme mechanism;Enzymes;first responder;Genetic Transcription;Goals;helicase;Human;immune activator;Immune response;Immunologic Receptors;In Vitro;kinetic model;Kinetics;Knowledge;Maintenance;Malignant Neoplasms;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;Mitochondrial RNA;Modeling;Molecular;Natural Immunity;Nucleic Acids;pathogen;Pattern;Polymerase;Process;Production;Property;Reaction;receptor;reconstitution;Regulation;Research;RNA;RNA Virus Infections;Role;Signal Transduction;single molecule;Structure;therapy development;transcription factor;Transcription Initiation;Vaccine Adjuvant;Viral;Viral Genome;viral RNA;Virus Diseases;Virus Replication;Work;Yeasts

PROJECT_TITLE: Mechanistic studies of nucleic acid enzymes involved in DNA replication, transcription, and innate immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Although vocal hyperfunction is linked to the most prevalent types of voice disorders, effective prevention and clinical management of these disorders continue to be hampered by limited knowledge of underlying etiological and pathophysiological mechanisms. To address this need, this Clinical Research Center brings together a multidisciplinary team of experienced investigators to pursue a comprehensive program of research focused on hyperfunctional voice disorders. Achieving the goals of this research program will lead to improved prevention, differential diagnosis, and more focused and efficient treatment of these highly prevalent conditions.

PI_NAMEs: HILLMAN, ROBERT E (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Ambulatory Monitoring;Applications Grants;Arousal;Auditory;Behavior Therapy;Behavioral;Benign;Biofeedback;biomechanical model;Biomechanics;Categories;Classification;Clinic;Clinical;Clinical Management;Clinical Research;clinical translation;Clinical Trials;Computer Models;Data;Data Science Core;Databases;design;Detection;Diagnosis;Differential Diagnosis;Dimensions;Disease;Disease Management;Disparate;Dysphonia;Emotional;endophenotype;Etiology;evidence base;experience;Functional disorder;Funding;Goals;Grant;human data;improved;innovation;insight;Interdisciplinary Study;Investigation;Knowledge;Laboratory Study;Larynx;Lesion;Life;Link;Measurement;Measures;Methods;Monitor;Motor;motor control;multidisciplinary;Muscle Tension;Musculoskeletal;neuroregulation;Nodule;novel;participant enrollment;Pathology;Patients;Phenotype;Phonation;physical model;Physiological;Polyps;Predisposing Factor;Prevention;Productivity;programs;psychologic;Psychometrics;Randomized Controlled Clinical Trials;Research;Research Personnel;Research Project Grants;Role;Solid;Source;Structure;Sum;Technology;Testing;Therapeutic;Training;Translating;Validation;vocal cord;Voice;Voice Disorders;voice therapy;Work

PROJECT_TITLE: Clinical Research Center for the Improved Prevention, Diagnosis, and Treatment of Vocal Hyperfunction


NIH_SPENDING_CATS: Clinical Research;Prevention

PROJECT_TERMS: Advisory Committees;Area;Auditory;authority;Award;Behavior Therapy;Behavioral;Biofeedback;biomechanical model;Boston;Budgets;Clinical Research;cohesion;Communication;Consensus;Consent;Data;data collection site;Data Science Core;Detection;Diagnosis;Disputes;Documentation;Ensure;Evaluation;Expenditure;experience;Failure;General Hospitals;Goals;Grant;Guidelines;Human;improved;Individual;Institution;Institutional Review Boards;Journals;Lead;Massachusetts;Medical center;meetings;Modeling;Monitor;motor control;multidisciplinary;Names;operation;Participant;Patient Recruitments;payment;Peer Review;Periodicals;Persons;Phenotype;Prevention;Problem Solving;Process;programs;Progress Reports;protocol violation;Protocols documentation;Publications;Publishing;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Resources;Running;Schedule;Site;Structure;success;symposium;Technology;Teleconferences;Time;timeline;United States National Institutes of Health;Universities;virtual;Voice;Voice Disorders

PROJECT_TITLE: Administrative Core: Clinical Research Center for the Improved Prevention, Diagnosis, and Treatment of Vocal Hyperfunction


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Health Relevance Unlike other retroviruses, lentiviruses including HIV-1 infect both activated/dividing CD4+ T cells and terminally differentiated/nondividing myeloid cells (e.g. macrophages and microglia) and also rapidly evolve through their robust genetic mutagenesis capability during the course of their pathogenesis. In this renewal, we aim to reveal noble mechanistic and structural strategies that lentiviruses employ for their cell tropism and rapid evolution/escape. Understanding of these unique viral strategies will ultimately assist the development of novel antiviral concepts and tools.

PI_NAMEs: KIM, BAEK  (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: 2019-nCoV;Acceleration;Affinity;Binding;Biochemical;CD4 Positive T Lymphocytes;Cells;Compensation;Complex;Data;Development;DNA;DNA biosynthesis;DNA Sequence Alteration;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;Elements;Enzyme Kinetics;Evolution;Genome;Genomics;Health;HIV-1;HIV-2;Infection;Interphase Cell;Investigation;Kinetics;Lentivirus;Macrophage;Mediating;Microglia;molnupiravir;multicatalytic endopeptidase complex;Mutagenesis;Mutagens;Mutation;Myelogenous;Myeloid Cells;Nature;novel;Pathogenesis;pharmacologic;Phenotype;Prodrugs;Proteins;Reporting;Retroviridae;Reverse Transcription;Ribonucleotides;RNA;RNA chemical synthesis;RNA Polymerase II;RNA Viruses;RNA-Directed DNA Polymerase;RNA-Directed RNA Polymerase;Roentgen Rays;Series;SIV;Structure;Testing;tool;tripolyphosphate;Tropism;Viral;Viral Genome;viral genomics;Viral Reverse Transcription;Virus Replication;X-Ray Crystallography

PROJECT_TITLE: Lentivirus Replication Strategy and Pathogenesis

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Natural Products;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: Nashville

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PUBLIC HEALTH RELEVANCE: Long-term affective withdrawal symptoms following opioid  dependence confer vulnerability for relapse and persistent drug use in patients. Cannabinoid-based  therapies are commonly sought to treat these symptoms acutely, however the mechanisms by which  these therapies work, how cannabinoid signaling is altered with opioid dependence, and the efficacies  of these drugs in mitigating relapse with long-term withdrawal is unknown. The goal of the proposed  studies is to identify changes in cannabinoid signaling in reward circuits and determine the effect  cannabinoids have on opioid motivation and drug taking during long-term withdrawal.

PI_NAMEs: GOMEZ, DEVAN MARC (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Acute;acute symptom;addiction;Affective;Behavior;Behavioral;behavioral study;cannabinoid treatment;Cannabinoids;Cell Nucleus;Cells;Characteristics;CNR1 gene;Code;Corpus striatum structure;cost;Data;Dependence;Detection;Development;Disinhibition;Dopamine;dopaminergic neuron;drug craving;drug efficacy;drug relapse;Drug usage;effective intervention;efficacious treatment;Electrophysiology (science);Epidemic;experimental study;Functional disorder;gamma-Aminobutyric Acid;Goals;Heterogeneity;Influentials;Intake;Intervention;Lateral;Measures;Mediating;mesolimbic system;Morphine;Morphine Dependence;motivated behavior;Motivation;negative affect;Nucleus Accumbens;Opiate Addiction;Opioid;opioid abuse;opioid use;opioid withdrawal;Patients;Pharmaceutical Preparations;Psychological reinforcement;public health relevance;Regulation;Relapse;Research;research and development;Rewards;Signal Transduction;Slice;symptom treatment;Synapses;System;Technical Expertise;Therapeutic;Ventral Tegmental Area;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Measuring effects of morphine withdrawal on dopaminergic salience coding across the striatum


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

PI_NAMEs: MEHTA, DARYUSH DINYAR (contact)

PROJECT_TERMS: Accelerometer;Acoustics;Aftercare;Agreement;Air Movements;Algorithms;Ambulatory Monitoring;Artificial Intelligence;Behavior;Biofeedback;Biometry;Boston;Calibration;Cellular Phone;central database;Classification;Clinic;Clinical;Clinical Research;Clinical Services;cloud storage;Code;Communication;Communities;computer science;Data;Data Analyses;Data Collection;data collection site;data integration;data management;data quality;Data Science;Data Science Core;Data Set;data sharing;Database Management Systems;Databases;deep learning;Detection;Devices;Diagnosis;Dimensions;Documentation;Effectiveness;Eligibility Determination;Enrollment;Ensure;Equation;Equipment;Evaluation;experience;General Hospitals;Health Occupations;Hour;human subject;image processing;improved;Institution;Institutional Review Boards;International;Laboratories;laboratory equipment;Language;Larynx;Linear Models;longitudinal analysis;Longterm Follow-up;Machine Learning;machine learning algorithm;Maintenance;Massachusetts;Measurement;Medical center;Modeling;Monitor;monitoring device;multidisciplinary;Neck;Operative Surgical Procedures;Paper;Participant;participant enrollment;Pathologist;Patients;Peer Review;Phase;pressure;Prevention;Productivity;programs;Protocols documentation;Publications;Research;Research Personnel;Resources;Role;Science;Secure;service learning;Services;signal processing;Signal Transduction;sound;Speech;Speed;statistical and machine learning;Stroboscopy;Sum;Surface;surgical research;symposium;Technology;technology development;Testing;tool;treatment services;Underrepresented Populations;unsupervised clustering;Voice;Voice Disorders;voice therapy;wearable device;web portal;wireless

PROJECT_TITLE: Technology and Data Science Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Regenerative Medicine

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Narrative Dysfunction of the specialized liver endothelial cells that line blood vessels could lead to loss of hepatocytes and scarring setting the stage for the progression of advanced liver disease, which is incurable except with a liver transplant, that is an expensive and challenging procedure. We have found previously unknown key factors, namely the transcription factors Erg, Fli1, and c-Maf, capable of specifying naïve mouse or human endothelial cells into functioning specialized liver sinusoidal blood vessels; that will enable approaches to uncover the signals that drive liver regeneration without causing scarring. We have proposed studies to decipher the underlying mechanisms by which the endothelial cells by vascularizing stellate, Kupffer cells and hepatocytes conduct their crosstalk, thereby setting the stage for designing strategies for a more effective and scar-free hepatic regeneration to achieve efficacious treatment for liver disease.

PI_NAMEs: RAFII, SHAHIN  (contact)

PROJECT_TERMS: 3-Dimensional;Acetaminophen;Adult;Angiopoietin-2;Anticoagulation;Biochemical;Biophysics;Blood;Blood Vessels;Capillarity;Cardiovascular system;Cell Line;Cell Physiology;Cells;Central Vein;Cicatrix;Cirrhosis;constitutive expression;design;Development;efficacious treatment;EGF gene;end stage liver disease;Endothelial Cells;factor C;fetal;FGF2 gene;Fibrosis;FLI1 Transcription Factor;Functional disorder;GATA4 gene;healing;Hepatectomy;Hepatic;Hepatic artery;Hepatocyte;Homeostasis;Human;Immune;Impairment;Inflammation Mediators;Inflammatory;Injury;Kupffer Cells;Liver;Liver diseases;Liver Dysfunction;liver function;liver injury;Liver Regeneration;liver repair;liver transplantation;Maintenance;Microfluidic Microchips;Molecular;Morbidity - disease rate;mortality;Mus;Natural regeneration;Nature;Organ;organ repair;Outcome Study;Partial Hepatectomy;Pathogenesis;Phenotype;Physiological;Portal vein structure;prevent;Procedures;Recovery;regeneration function;regenerative;repaired;Research;Role;self assembly;Signal Transduction;Specific qualifier value;stellate cell;stem cells;Stress;Testing;therapy development;Tissues;transcription factor;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vascularization;Vasomotor;WNT2 gene

PROJECT_TITLE: Molecular Determinants of liver sinusoidal endothelial cells for hepatic regeneration


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Machine Learning and Artificial Intelligence;Prevention

PHR: Project Narrative Vocal hyperfunction (VH) is linked to the most prevalent types of voice disorders, but effective prevention and clinical management of these conditions continue to be hampered by limited knowledge of the etiological and pathophysiological mechanisms associated with VH. This project will use data from ambulatory voice monitoring as well as other sources to elucidate several factors that are assumed to play important roles in causing and maintaining hyperfunctional voice disorders. Achieving the goals of this research program will lead to improved prevention, differential diagnosis, and more focused and efficient treatment of these very prevalent conditions.

PROJECT_TERMS: Acoustics;Adult;Affect;Aftercare;Age;Aphonia;Auditory;Behavior;Behavioral;Benign;Biofeedback;Calibration;Categories;Clinical;Clinical Management;Clinical Research;clinical translation;Data;Data Collection;data collection site;Data Science Core;Databases;design;Detection;Diagnosis;Differential Diagnosis;Dimensions;Disease;Dose;Dysphonia;endophenotype;Ensure;Etiology;Fatigue;Formulation;Functional disorder;Goals;Grant;Heterogeneity;Image;improved;Individual;insight;Knowledge;Laboratories;Laryngeal muscle structure;Larynx;Lesion;Life;Link;Machine Learning;machine learning classifier;Maps;Measures;Methods;Modeling;Monitor;Motor;motor deficit;Muscle Tension;Musculoskeletal;Neurologic;Nodule;Occupations;Participant;patient subsets;Patients;Performance;Personality;Persons;Phenotype;Phonation;Physiological;Physiology;Play;Polyps;Population;precision medicine;Predisposing Factor;pressure;prevent;Prevention;Procedures;programs;Recording of previous events;Recovery;Reflux;Research;response;Rest;Role;Sampling;Series;sex;sound;Source;Specificity;statistical and machine learning;Subgroup;Techniques;Technology;Time;Training;Trauma;Treatment outcome;United States;unsupervised learning;vocal cord;vocal learning;Voice;Voice Disorders;voice therapy;Work

PROJECT_TITLE: Identifying physical and behavioral factors and mechanisms to improve detection and phenotyping of vocal hyperfunction


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ALBUQUERQUE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE Snail control has proven to be one of the most effective means for controlling schistosomiasis. Better understanding of molecular mechanisms that underlie snail resistance to schistosomes have significant potential to lead to novel interventions that block transmission of schistosomiasis at the intra-molluscan stage.

PI_NAMEs: ZHANG, SI-MING  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Adolescent;Adult;Advocate;Affect;Alleles;Area;Attention;Biomphalaria;Brazil;Breeding;Bulinus;Candidate Disease Gene;Chromosome Mapping;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;comparative;comparative genomics;Competence;constitutive expression;cost effective;Coupled;CRISPR interference;Data;Development;differential expression;disease transmission;Foundations;Fresh Water;functional genomics;Generations;Genes;Genetic;genetic analysis;genetic approach;Genetic Recombination;genetic resistance;genetic resource;Genetic study;Genetic Variation;Genitourinary system;Genome;genome editing;genome resource;genome sequencing;genome-wide;Genomic approach;Genomic Segment;Genomics;Germ Lines;Human;Immunobiology;Immunologics;Inbreeding;Individual;Infection;insight;International;Intervention;Intestines;knock-down;Knock-out;Knowledge;Laboratory Finding;Maps;Methods;Modeling;Modernization;Molecular;neglected tropical diseases;novel;Parents;Persons;Phenotype;Population;Poverty Areas;Predisposition;programs;public health relevance;Quantitative Trait Loci;Reporting;Resistance;resistance gene;Resolution;response;RNA analysis;RNA Interference;Role;Scanning;Schistosoma;Schistosoma haematobium;Schistosoma mansoni;Schistosome Parasite;Schistosomiasis;Single Nucleotide Polymorphism;Snails;success;System;Technology;Testing;tool;transcriptome sequencing;transcriptomics;transmission blocking;transmission process;Variant;vector;whole genome

PROJECT_TITLE: Genetics and genomics of schistosome resistance in snails

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative The proposed project will decipher the regulation of critical neuromodulator signaling that mediates social behavior and is disrupted in brain disorders. The knowledge gained through this effort may lay the foundation for development of therapeutics strategies for alleviating social deficits in neuropsychiatric illnesses such as autism spectrum disorder.

PI_NAMEs: AHMAD, MOHIUDDIN  (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Agonist;Animal Behavior;anxiety-related behavior;Arrestins;autism spectrum disorder;autism symptoms;Behavioral;Binding;Brain;Brain Diseases;Brain region;C-terminal;Communication;Complex;Coupling;CRISPR/Cas technology;Data;debilitating symptom;decay acceleration;desensitization;Disease;Electrophysiology (science);experimental study;Foundations;Future;G protein coupled receptor kinase;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Generations;GTP-Binding Proteins;Hormones;Impairment;In Vitro;in vivo;insight;Interneurons;Intranasal Administration;Investigation;knock-down;Knock-in Mouse;Knowledge;Label;Lactation;Mediating;Mental disorders;Modality;Molecular;Mus;Mutagenesis;mutant;Mutate;Neuromodulator;neuronal circuitry;Neurons;neuropsychiatric disorder;neuropsychiatry;novel;novel therapeutic intervention;Oxytocin;Oxytocin Receptor;Palmitic Acylation Site;palmitoylation;Pharmaceutical Preparations;Phosphorylation;Phosphorylation Site;Post-Translational Protein Processing;prevent;Prevention;Process;Property;protein complex;Protein Isoforms;Proteins;Proteomics;receptor;Receptor Activation;receptor internalization;Receptor Signaling;recruit;Regulation;response;Role;Signal Pathway;Signal Transduction;Slice;social;Social Behavior;social cognition;Social Controls;social deficits;Structure;System;Tail;Techniques;Testing;therapeutic development;Time;Virus;Work

PROJECT_TITLE: Regulation of Oxytocin Receptor Signaling in Neurons

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: NARRATIVE Advances in DNA sequencing and synthesis have enabled new ways to understand how differences in the genome affect gene expression. Many important signals between and within cells happen downstream of gene expression, through the post-translational modiﬁcation of proteins. We propose an innovative technique to better understand how genetic variation affects these post-translational signals.

PI_NAMEs: INGOLIA, NICHOLAS T (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Affect;Amino Acid Sequence;Bar Codes;base editor;Binding;Biological;Biological Assay;Cell Physiology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;CRISPR/Cas technology;deep sequencing;Disease;DNA biosynthesis;DNA Sequence;DNA sequencing;driver mutation;Drug resistance;Enhancers;Ensure;Enzymes;experimental study;Gene Expression;Genes;Genetic;Genetic Transcription;genetic variant;Genetic Variation;Genome;Goals;Health;High-Throughput Nucleotide Sequencing;Individual;innovation;interest;kinase inhibitor;Libraries;link protein;Malignant Neoplasms;Maps;Measurement;Measures;Mediating;Molecular;mRNA sequencing;Mutagens;Mutation;novel;Nucleotides;Oncogenic;Outcome;Peptide Hydrolases;Phenotype;Phosphorylation;Phosphotransferases;Post-Translational Protein Processing;Post-Translational Regulation;promoter;protein function;Protein Kinase;Proteins;Regulation;Reporter;response;RNA;RNA-Binding Proteins;Signal Pathway;Signal Transduction;Small RNA;Techniques;Testing;transcription factor;Transcriptional Regulation;Transformed Cell Line;Transgenic Organisms;Translation Process;Translations;Variant;Viral;Work

PROJECT_TITLE: Post-translational phenotypic profiling through nucleotide barcode sequencing

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Nutrition;Obesity;Precision Medicine;Prevention;Rare Diseases

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Amyotrophic lateral sclerosis (ALS) remains an urgent public health problem due to a lack of established biomarkers for early diagnosis and treatment to delay disease progression. While it is known that metabolic changes that affect disease progression occur early in the course of clinical disease, the cause or consequence of these metabolic changes are not well understood. To develop novel diagnostic biomarkers and identify treatment target(s) for ALS, I will focus this study on the metabolic changes in ALS by examining lipid mediators, body weight and composition, energy expenditures and other factors in groups of participants diagnosed with ALS, pre-ALS, or primary lateral sclerosis.

PI_NAMEs: LEE, IKJAE  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Adult;Affect;algorithm training;ALS patients;Amyotrophic Lateral Sclerosis;Area;biobank;Biological Markers;biomarker development;Biometry;Blood;Body Composition;Body mass index;Body Weight;C9ORF72;Cessation of life;Classification;Clinic;Clinical;clinical application;Clinical Course of Disease;cohort;Cohort Studies;comparison control;Control Groups;Data;Data Set;Deglutition Disorders;Development;Diagnosis;Diagnostic;diagnostic biomarker;Differential Diagnosis;Disease;Disease Progression;disease-causing mutation;drug development;early detection biomarkers;Early Diagnosis;Early identification;Early Intervention;Early treatment;effective therapy;Energy Intake;Energy Metabolism;Epidemiology;Expenditure;familial amyotrophic lateral sclerosis;Family;Fatty acid glycerol esters;fatty acid oxidation;Foundations;Genetic Predisposition to Disease;Genetic Risk;Goals;Height;indexing;Individual;insight;Knowledge;Learning;lipid mediator;lipid metabolism;lipidome;lipidomics;Lipids;Longitudinal cohort study;longitudinal, prospective study;Machine Learning;machine learning algorithm;Measures;Mentored Patient-Oriented Research Career Development Award;Metabolic;Metabolic Marker;metabolic profile;Metabolism;mitochondrial dysfunction;Motor Neuron Disease;Motor Neurons;Muscle Weakness;mutation carrier;Natural History;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Dysfunction;Newly Diagnosed;novel;novel diagnostics;Oxidative Stress;Participant;Pathogenesis;Pathogenicity;Pattern;phenotypic biomarker;Plasma;Population;Positioning Attribute;predictive marker;predictive tools;prevent;Primary Lateral Sclerosis;Probability;Production;Prospective, cohort study;Public Health;Reporting;Research;Research Personnel;Research Training;Respiratory Failure;Rest;Sampling;Signs and Symptoms;skills;sporadic amyotrophic lateral sclerosis;Stress;supervised learning;Symptoms;Techniques;therapeutic target;total energy expenditure;United States;Universities;Validation;Variant;Weight

PROJECT_TITLE: Metabolic Alteration in Presymptomatic and Symptomatic ALS Study (MAPS ALS Study)

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


PHR: Project Narrative Vocal hyperfunction is a condition that accounts for nearly half of the 3 – 9% of the U.S. population with voice disorders. It often presents with no known structural or neurological cause. This project will test the hypothesis that vocal hyperfunction is related to underlying auditory-motor impairment, allowing for future development of new treatments.

PI_NAMEs: STEPP, CARA E. (contact)

PROJECT_TERMS: accurate diagnosis;Acoustics;Address;Arousal;Auditory;auditory feedback;Autonomic nervous system;Behavior Therapy;Behavioral;Calibration;Clinic;Clinical;clinical application;Clinical assessments;clinical implementation;Clinical Research;clinical translation;Clinical Treatment;Cognitive;Complex;Data;Development;Diagnosis;Dysphonia;endophenotype;Environment;Etiology;Exposure to;Frequencies;Friends;Functional disorder;Funding;Future;Hearing;Hygiene;Impairment;improved;Individual;insight;instrumentation;Larynx;Maintenance Therapy;Measures;Methods;Modeling;Monitor;Motor;motor control;motor impairment;Nervous System Physiology;neural;Neurologic;Patients;personalized medicine;Phenotype;Physiological;Population;Predisposing Factor;Prevention;Production;Protocols documentation;Psychological Factors;Psychometrics;Readiness;Recurrence;Reflux;response;Role;Secondary to;sound;Speech;stressor;Subgroup;Testing;therapy outcome;treatment response;Voice;Voice Disorders;Voice Quality;voice therapy;Vulnerable Populations;Work

PROJECT_TITLE: Sensorimotor mechanisms of vocal hyperfunction


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE G protein-coupled receptor signaling is important in almost every aspect of cardiovascular physiology and contributes to cardiovascular pathophysiology, however mechanistic insight is lacking, which is an impediment to discovering more efficacious medicines. This proposal addresses a previously unknown role for a post- translational modification termed ubiquitination in regulating GPCR signaling. This project has the potential to reveal that targeting the ubiquitin pathway may be beneficial to treat cardiovascular disease involving GPCR signaling.

PI_NAMEs: MCELRATH, CHANDLER J (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Adaptor Signaling Protein;Address;Agonist;amino group;angiogenesis;Arginine;Arrestin Beta 1;Automobile Driving;beta-arrestin;Biochemical;Biological Assay;Biology;biophysical techniques;Biophysics;C-terminal;cardiac repair;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;cell motility;Cells;chemokine receptor;Communities;Complex;CXC Chemokines;Data;Degradation Pathway;Disease;Down-Regulation;Endosomes;Endothelial Cells;Environment;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic Transcription;Glycine;Health;Heart;improved;In Vitro;Innate Immune Response;insight;Ligands;Ligation;Link;Lysine;Lysosomes;Mass Spectrum Analysis;Mediating;medical schools;Medicine;Mentorship;Methionine;Molecular;Multivesicular Body;Mutate;Myocardial Infarction;neovascularization;NF-kappa B;novel;Pathway interactions;Peptides;Play;Polyubiquitin;Polyubiquitination;Post-Translational Protein Processing;protein purification;Proteins;reconstitution;Recovery;Role;Signal Pathway;Signal Transduction;Site;Site-Directed Mutagenesis;Sorting;Stromal Cell-Derived Factor 1;System;Testing;Therapeutic;trafficking;Translations;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Wisconsin

PROJECT_TITLE: The role of ubiquitin in GPCR signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-U(20)L]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Dental, Oral, and Craniofacial Disease;Orphan Drug;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Positive margins are reported in up to 30% of head and neck cancer surgeries, where margin status is a major prognostic factor for overall survival. Achieving complete tumor resection is critical to preventing cancer reoccur- rence and promoting optimal postoperative outcomes. We will develop first-in-class, near infrared, fluorogenic, tumor-targeted probes as an intraoperative aid to improve tumor margin and small lesion detection in head and neck cancer surgery.

PI_NAMEs: WANG, LEI GARRETT (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Address;Adopted;Adoption;Affinity;Anatomy;Antibodies;Behavior;Binding;Biological Markers;cancer surgery;cancer type;candidate selection;chromophore;Circulation;Classification;Clinical;clinical implementation;Clinical Medicine;clinical practice;Clinical Trials;clinically relevant;Contrast Media;cost;Cues;cytotoxicity;Decision Making;design;Detection;Development;Diagnosis;Disease;Drug Kinetics;Electron Transport;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Evaluation;Event;Excision;Extravasation;falls;FDA approved;Fluorescence;fluorescence-guided surgery;fluorophore;Future;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;high resolution imaging;Hospitals;Image;Impairment;improved;in vitro Assay;in vivo;Indocyanine Green;inhibitor;Injections;Knowledge;Label;lead candidate;Lesion;Ligands;liquid chromatography mass spectroscopy;Malignant Neoplasms;Methodology;Methylene blue;molecular dynamics;mouse model;mutant;NMR Spectroscopy;Nodule;novel;Operative Surgical Procedures;Optics;Outcome;Palpation;Patients;Penetration;Peptides;Pharmacodynamics;Postoperative Period;pre-clinical;prevent;Prognostic Factor;Property;receptor binding;Reporting;Rodent;Sensitivity and Specificity;Signal Transduction;small molecule;Specificity;Stress;Structure;surgery outcome;System;Technology;Time;Tissue Preservation;Tissues;Translations;tumor;tumor specificity;Ultrasonography;Validation;Visit;Visual;Work;X-Ray Computed Tomography

PROJECT_TITLE: Small Molecule Probes for Fluorescence-guided Head and Neck Cancer Surgery

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Diabetes;Emerging Infectious Diseases;Infectious Diseases;Nutrition;Obesity;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

PHR: Public Health Relevance The deadly COVID-19 pandemic is underscored by the high morbidity and mortality rates seen in certain vulnerable populations, including patients with diabetes mellitus (DM) and obesity. Despite this well-known association, our understanding of how and why this occurs is lacking leading to an absence of specific therapies. In this proposal, we aim to test the mechanisms by which COVID-19 leads to adverse outcomes in diabetes mellitus and obesity with the goal of developing new therapies for patients with COVID-19.

PI_NAMEs: LO, JAMES C (contact);SCHWARTZ, ROBERT E

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: 2019-nCoV;Acute;acute COVID-19;Adipocytes;adipokines;adiponectin;Adipose tissue;adverse outcome;Attenuated;Automobile Driving;Autopsy;Beta Cell;Biochemical;blood glucose regulation;Cell Physiology;cell type;Cells;Circulation;combat;comparison control;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 susceptibility;Cytometry;Data;Death Rate;Defect;Diabetes Mellitus;Disease;Endocrine Glands;Experimental Models;Failure;Fatty acid glycerol esters;follow-up;Functional disorder;Genes;glucose metabolism;glucose tolerance;Goals;Hamsters;Health;Homeostasis;Hormones;Hyperglycemia;Image;Immunity;impaired glucose tolerance;Impairment;in vivo;Individual;Infection;Inflammatory;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;Interferons;IRF3 gene;Length of Stay;Long COVID;Maps;Mechanical ventilation;Metabolic;Metabolic Diseases;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Non obese;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obese Mice;Obesity;old mice;Pathogenesis;Pathology;Pathway interactions;Patients;Physiological;Play;post SARS-CoV-2 infection;preservation;programs;public health relevance;receptor;Recovery;Role;Sampling;SARS-CoV-2 infection;SARS-CoV-2 variant;Specimen;symptom treatment;Testing;Thinness;trait;Virus Replication;Vulnerable Populations

PROJECT_TITLE: Assessing the Impact of SARS-CoV-2 on Adipose Tissue Function and Glucose Homeostasis

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Congenital Structural Anomalies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pregnancy;Prevention;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative We propose to study how mothers’ exposures to wildfire smoke during pregnancy may affect risk of birth defects and if that relationship is different among areas with social vulnerability or different housing structures.

PI_NAMEs: PADULA, AMY MICHELLE (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Address;Affect;Age;Air;Air Conditioning;Air Pollution;ambient air pollution;Area;Aromatic Polycyclic Hydrocarbons;Birth;bone;Brain;Burn injury;California;Case/Control Studies;Censuses;Characteristics;Child;climate change;climate zone;Clinical;Collection;Communities;Congenital Abnormality;critical period;Data;Data Set;Databases;Defect;density;Development;Ear;early pregnancy;Embryo;embryo/fetus;Etiology;Event;experience;Exposure to;Eye;Face;factor A;Fetus;fine particles;Fire - disasters;Frequencies;hazard;Health;heart defect;Housing;Human;human old age (65+);indexing;Infant;Infant Mortality;Knowledge;Maps;Measurement;Meteorology;Modeling;Monitor;Mothers;Muscle;National Oceanic and Atmospheric Administration;Neighborhoods;Neural Tube Defects;Oral cavity;Ozone;Participant;participant interview;Particulate Matter;perinatal health;Persons;Pharmaceutical Preparations;Physicians;Population;population based;Population Study;Pregnancy;pregnant;prenatal exposure;Prevention;Psychosocial Stress;public health intervention;Recording of previous events;reproductive organ;Research Personnel;residence;Risk;Risk Estimate;Smoke;Social support;social vulnerability;Socioeconomic Status;socioeconomics;Source;Structural Congenital Anomalies;Structure;study population;System;Teratogens;therapy design;United States;United States Environmental Protection Agency;Vertebral column;Wildfire

PROJECT_TITLE: Wildfire Smoke Exposure in Pregnancy and Risk of Structural Birth Defects

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


PHR: Project Narrative This project seeks to determine the underlying physical and neurophysiological mechanisms associated with vocal hyperfunction, with the goal of identifying triggering mechanisms and differentiating cause from reaction in these disorders. The proposed modeling framework consists of numerical and experimental components that will provide unique insights into the underlying biomechanical, aero-acoustic, and auditory-motor control mechanisms. In addition, subject-specific model representations will provide access to additional measures and insights from the available data that will help to elucidate the etiology and pathophysiology of vocal hyperfunction.

PI_NAMEs: ZANARTU, MATIAS  (contact)

PROJECT_TERMS: Acceleration;Address;Ambulatory Monitoring;Articulators;Auditory;Bayesian Modeling;Behavior;behavioral response;biomechanical model;Biomechanics;Chronic;Classification;Clinical;Clinical Research;clinically relevant;Collaborations;computer framework;Computer Models;Data;Development;Diagnosis;Disease;Dose;Edema;Elements;Etiology;Fibrosis;Functional disorder;Goals;Grant;healing;Impairment;improved;Individual;insight;Investigation;Laryngeal muscle structure;Larynx;Measures;Mechanical Stress;Methods;Modeling;models and simulation;Monitor;Motor;motor control;motor impairment;Musculoskeletal;Nature;neural;neurophysiology;neuroregulation;Noise;Outcome;Output;Pathway interactions;Pattern;Phenotype;Phonation;physical model;Physiological;Plants;Population Distributions;Prevention;Quality Control;Reaction;Research;response;Role;Speech;Structure;Swelling;Tissues;Translations;vocal cord;Voice;Voice Disorders;Voice Quality;voice therapy

PROJECT_TITLE: Modeling biomechanical, aero-acoustic, and auditory-motor control mechanisms of vocal hyperfunction


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Complementary and Integrative Health;Prevention;Rehabilitation

PHR: Project Narrative Vocal hyperfunction (VH) is the most commonly treated class of voice disorders by speech-language pathologists and voice therapy is the primary curative treatment. Patients and clinicians report that generalizing improved voicing into daily life is the most significant barrier to successful therapy. We will test if extending biofeedback into the patient’s daily life using ambulatory voice monitoring will significantly improve generalization during therapy and if individual patient factors, like how easily they can modify their voice and engagement during therapy, moderate the effects of the biofeedback.

PI_NAMEs: VAN STAN, JARRAD  (contact)

PROJECT_TERMS: Address;Adopted;Air Movements;Ambulatory Monitoring;Auditory;Behavior;Behavior Therapy;Biofeedback;Calibration;Clinic;Clinical;Clinical assessments;clinical care;clinical practice;Clinical Research;Clinical Trials;Control Locus;Cues;curative treatments;Data;Diagnosis;Dropout;Dysphonia;evidence base;Excision;Feedback;Future;improved;individual patient;individualized medicine;Informal Social Control;innovation;insight;Language;Larynx;Lesion;Life;Loudness;Measurement;Measures;Mediating;Methods;Modeling;Monitor;Motivation;Motor Skills;Muscle;Muscle Tension;Nodule;novel;Operative Surgical Procedures;Pathologic;Pathologist;Patient Dropouts;patient engagement;patient subsets;Patients;Personality;Phenotype;Physiological;pressure;Prevention;Process;Randomized;Recurrence;Rehabilitation therapy;relapse prevention;Reporting;Research;research study;Risk;Severities;Speech Disorders;Stress;targeted treatment;Testing;Therapeutic;Time;Training;treatment group;virtual;vocal cord;Voice;Voice Disorders;voice therapy;Work

PROJECT_TITLE: Use of ambulatory biofeedback to improve behavioral treatment of vocal hyperfunction


PHR: Inhibitory neurotransmission controls the activity and synchrony of excitatory neurons, and impaired inhibition contributes to the pathomechanism of neurological disorders such as epilepsy. The current experiments will determine whether specific types of inhibitory neurons are more effective at suppressing epileptic activity in the neuronal circuit without disrupting information encoding and may identify strategies to prevent seizures without adverse effects on cognitive function.

PI_NAMEs: DUDOK, BARNA  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Adverse effects;Affect;Animal Model;Animals;anti-epileptic agents;Area;Automobile Driving;awake;Brain;Calcium;career;career development;cell type;Cells;Cessation of life;Cholecystokinin;Chronic;Code;Cognitive;cognitive function;Data;Educational process of instructing;efficacy evaluation;Electrophysiology (science);Embryo;entorhinal cortex;Environment;Epilepsy;epileptiform;excitatory neuron;experimental study;Failure;Foundations;Frequencies;Functional disorder;Gamma synuclein;genetic strain;Glutamates;Goals;Grant;High Frequency Oscillation;Hippocampus;Image;Immunohistochemistry;Impaired cognition;Impairment;In Vitro;in vivo;inhibitory neuron;Injury;Interneurons;Intervention;kainate;Label;Medial;Mentors;Modeling;Molecular;Morphology;Mus;Myoepithelial cell;Nervous System Disorder;neuronal circuitry;Neurons;neurotransmission;Neurotransmitters;novel;optogenetics;Outcome;Parvalbumins;Pathologic;Patients;Persons;Pharmaceutical Preparations;Pharmacogenetics;Phase;Population;preservation;prevent;programs;Property;Pyramidal Cells;recruit;Recurrence;Research;Research Methodology;Risk;Role;segregation;Seizures;side effect;synuclein;System;Temporal Lobe Epilepsy;Testing;therapy development;Time;tool;Training;training opportunity;Transgenic Mice;Transgenic Organisms;treatment strategy;two-photon;Universities;Writing

PROJECT_TITLE: Perisomatic inhibition in epilepsy

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: OMAHA

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE  ATP-dependent chromatin remodelers are molecular machines responsible for organizing the packaging of DNA in our genomes. Defects in their function and regulation are found in about one-fourth of all cancers, and in a variety of developmental disorders. This project will provide key insights into the molecular mechanisms by which these remodelers achieve their specific biological functions.

PI_NAMEs: BRAHMA, SANDIPAN  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acute;Address;Affect;ARID1A gene;Automobile Driving;Binding;Biochemical;Bioinformatics;Biological Process;British Columbia;Catalytic Domain;Cell Physiology;cell type;Cells;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;chromosomal location;Cleavage Under Targets and Release Using Nuclease;Complex;Data;Defect;design;Development;developmental disease;Disease;DNA;DNA Packaging;Enhancers;Environment;epigenomics;exome sequencing;Family;Foundations;Fred Hutchinson Cancer Research Center;Frequencies;Future;Gene Activation;Gene Expression;Genes;Genetic Transcription;Genome;genome sequencing;genome-wide;Genomic Segment;Genomics;Goals;Heterogeneity;Histones;Human Genome;in vivo;Individual;insight;Kinetics;Knowledge;Label;Lead;Link;Malignant Neoplasms;Maps;Mentors;Micrococcal nuclease digestion of chromatin followed by sequencing;Modeling;Molecular;molecular imaging;Molecular Machines;Mouse Embryonic Stem Cells;Mutation;Nervous System Disorder;novel;novel strategies;Nucleosomes;Phase;polybromo;Polycomb;Positioning Attribute;Precision Run-On Sequencing;preference;Process;promoter;Protein Complex Subunit;Protein Subunits;Proteins;recruit;Regulation;Regulatory Element;Repression;Research;Research Personnel;Residual state;Resolution;Role;Saccharomycetales;Scientist;single molecule;Site;SMARCA4 gene;SMARCB1 gene;Specificity;stem cell differentiation;stem cells;Structure;superresolution microscopy;Supervision;SWI/SNF Family Complex;targeted treatment;Techniques;Testing;Time;Tissues;Training;transcription factor;Transcriptional Regulation;Universities;Variant

PROJECT_TITLE: Genome-wide mechanisms and dynamics of ATP-dependent chromatin remodeling complexes

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Behavioral and Social Science;Prevention

ORG_CITY: MADISON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: NARRATIVE This advanced course will provide training in innovative approaches to randomized behavioral clinical trials. It consists of a 4-day, in-person meeting followed by 9 monthly, virtual, group-based meetings. The short course will use a train-the-trainer approach and variety of modalities, including a public facing website, to extend the reach of the training to researchers beyond course participants.

PI_NAMEs: VOILS, CORRINE IONE (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Adoption;Behavior Therapy;Behavioral;behavioral clinical trial;Behavioral Medicine;Behavioral Model;cancer risk;cancer survival;cancer therapy;cardiometabolic risk;career;Clinical;Clinical Trials Design;cohort;Complement;Course Content;Data;design;Devices;Dissemination and Implementation;Educational workshop;effectiveness trial;efficacy trial;Evaluation;evidence base;experience;Faculty;Feedback;Funding Agency;Guidelines;Health Campaign;Hour;Hybrids;implementation trial;improved;improved outcome;innovation;Institution;Instruction;Insurance Coverage;Intervention;Intervention Studies;Knowledge;Learning;learning community;learning materials;Medical;meetings;member;Mentorship;Methodology;Methods;Modality;Modeling;next generation;Participant;peer coaching;Persons;Pharmacotherapy;podcast;Policies;Process;Program Evaluation;programs;Public Health;Quality of life;Randomized;randomized, clinical trials;research and development;Research Methodology;Research Personnel;Research Project Grants;Risk Reduction;Science;Scientist;Surveys;symposium;Techniques;therapy development;Trainers Training;Training;Translational Research;United States National Institutes of Health;virtual;web site;Work

PROJECT_TITLE: Innovative approaches to randomized behavioral clinical trials

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-R (50)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Pediatric

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE Through the development and provision of an in-person summer intensive short course, the proposed research training program is designed to expose researchers in learning and developmental sciences to principles and best practices in research data management and data sharing. The course will increase researchers’ knowledge, understanding, and comfort with data management and data sharing practices, remove salient barriers to data sharing, and thereby has the potential to increase the uptake of data sharing in the field of learning and developmental science.

PI_NAMEs: HART, SARA ANN;LOGAN, JESSICA ANN (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Adult;Area;Behavior;Belief;Budgets;career;Case Study;Child;Community of Practice;Complement;Data;data cleaning;Data Collection;data dictionary;data management;data repository;Data Set;data sharing;data sharing networks;data standards;design;Development;Documentation;education resources;Educational process of instructing;Enrollment;experience;Exposure to;Faculty;FAIR principles;field study;Funding;Goals;Grant;improved;innovation;Knowledge;Learning;online community;Persons;Policies;Population;Positioning Attribute;Procedures;Psychological Transfer;Reporting;Research;research in practice;Research Personnel;Research Training;response;scaffold;Science;Scientist;Self Efficacy;skills;theories;Time;tool;Training;Training Programs;United States National Institutes of Health;uptake;webinar;Work

PROJECT_TITLE: Data Management for Data Sharing: A Short Course for Researchers in Children’s Learning and Development


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLLEGE PARK

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: This diversity supplement will help develop sampling algorithms at the interface of statistical mechanics and artificial intelligence to probe mechanisms for rare event processes, such as drug unbinding and conformational change in drug targets. Through this supplement, the mentee will work on two different but interconnected projects that impact both Areas from the originally funded proposal. The key idea is to develop and apply Graph Neural Networks (GNNs) based approaches in two different ways relevant to practical and cost-effective drug design and computational biophysics.

PI_NAMEs: TIWARY, PRATYUSH  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Algorithms;Area;Artificial Intelligence;Artificial Intelligence enhanced;Award;Biophysics;cost effective;design;Drug Design;Drug Targeting;Event;Funding;graph neural network;Health;Ligands;Molecular;Molecular Conformation;Network-based;Pharmaceutical Preparations;Process;Research;Sampling;simulation;Statistical Mechanics;Work

PROJECT_TITLE: Supplement to promote diversity: From atoms to mechanisms - Artificial Intelligence augmented molecular simulations for mechanistic ligand design.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(07)-R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Complementary and Integrative Health;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative The overarching goal of this R25 proposal is to renew and expand the Michigan Integrative Well-Being and Inequality (MIWI) Training Program, a state-of-the-art program designed to enhance the methodological skills of interdisciplinary early-career scientists conducting integrative health research. Biological, psychological, social, and environmental aspects of health are often siloed in research, clinical care, and scientific training, reflecting a piecemeal approach to health that fails to meet the needs of persons with complex conditions. This hybrid training program builds on our successful track-record mentoring junior scientists and leverages extensive institutional resources and a national network of expert consultants to provide focused methodology training in integrative health research.

PI_NAMEs: MEZUK, BRIANA  (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Address;African American;Aging;analytical tool;Attention;Behavioral;behavioral and social science;Biological;Biological Factors;Biosocial;care systems;career;case-based;Clinical;clinical care;cohort;Collaborations;Complex;COVID-19 disparity;COVID-19 morbidity;COVID-19 pandemic;Data Collection;design;Development;Diabetes Mellitus;Diagnostic;Discipline;Disparity population;economic disparity;Education;Educational workshop;Empirical Research;Ensure;Environmental Risk Factor;Equity;ethnic minority;Ethnic Origin;Evaluation;experience;Fatigue;Feeling;Fostering;Funding;Goals;Growth;hands-on learning;Health;health inequalities;Health Sciences;Health Services;Heart Diseases;Hybrids;Individual;Inequality;Institution;Integrative Medicine;interest;Intervention;Knowledge;Leadership;Learning;Link;Loneliness;Malignant Neoplasms;marginalized population;Measurement;Measures;Mental disorders;Mental Health;Mentors;Methodology;Methods;Michigan;minority communities;Minority Groups;minority health;minority health disparity;Minority Health Research;minority investigator;minority scientist;Modeling;Modification;Morbidity - disease rate;multidisciplinary;National Center for Complementary and Integrative Health;Nature;neighborhood disadvantage;neurophysiology;novel;Outcome;Pain;Participant;peer;peer coaching;peer networks;peer support;Performance;Personal Satisfaction;Persons;physical conditioning;population health;Process;Productivity;programs;Progress Reports;Protocols documentation;psychologic;psychological distress;psychosocial;Psychosocial Assessment and Care;Psychosocial Factor;Public Health;Race;racial disparity;racial minority;recruit;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Research Training;Resources;response;Science;Scientist;skill acquisition;skills;Sleep disturbances;social;social capital;social epidemiology;Social Sciences;Structure;success;summer institute;Symptoms;Techniques;Technology;Theoretical model;Time;tool;Training;Training Programs;Underrepresented Minority;United States National Institutes of Health;Universities;virtual;Washington;webinar;Work

PROJECT_TITLE: Summer Training Program in Integrative Methods for Mental and Physical Health


NIH_SPENDING_CATS: Natural Products

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative: Polyketides are used more in human medicine than any other class of secondary metabolites, and comprise roughly 20% of top-selling small-molecule drugs. This project advances catalytic methods for the de novo chemical synthesis of polyketides based on hydrogen auto-transfer processes that enable direct stereo- and site-selective conversion of lower alcohols to higher alcohols. Polyketide natural products that possess anti-cancer and anti- bacterial properties are targeted.

PI_NAMEs: KRISCHE, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Polyketides via Redox-Triggered Alcohol C-H Functionalization.


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Nutrition

ORG_NAME: JOSLIN DIABETES CENTER

PHR: Narrative  Responses to metabolic and other stresses play critical roles in development, many diseases, metabolism, and aging. This diversity supplement project investigates how specific metabolites regulate appetite and feeding behavior in C. elegans, and provides scientific training and development that will prepare Ms. Hussein-Fricke for entry into a PhD program.

PI_NAMEs: BLACKWELL, T KEITH (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TITLE: Signaling mechanisms that detect stress and maintain homeostasis - Research Supplement to Promote Diversity in Health-Related Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Emergency Care;Health Services;Mental Health;Natural Products;Neurosciences;Patient Safety;Pediatric;Substance Misuse

ORG_CITY: LAKEWAY

ORG_NAME: ANEBULO PHARMACEUTICALS, INC.

PHR: PROJECT NARRATIVE Recent legalization of cannabis in a growing number of States across the U.S. has led to a rapid increase in availability and use of cannabis and cannabis products, in a wide range of inhaled and edible forms that are potent and inexpensive, and this in turn has led to an exponential surge in emergency department (ED) visits for acute cannabinoid intoxication (ACI). This project aims to further advance Anebulo Pharmaceutical’s clinical development of an emergency treatment for ACI: ANEB-001, a CB1 antagonist shown to rapidly reverse the key symptoms of ACI after single oral doses in a Phase 2 THC challenge study in healthy subjects. Ultimately, providing ANEB-001 as an intravenous antidote for ACI and potentially cannabis hyperemesis syndrome (CHS) in the ED could address this rapidly growing unmet need, particularly for children and vulnerable patients at greatest risk of potentially life- threating adverse events, while also reducing the burden on the US healthcare system.

PI_NAMEs: CUNDY, KENNETH  (contact)

PROGRAM_OFFICER_NAME: REICHEL, CARMELA MARIE

PROJECT_TERMS: Accident and Emergency department;Acute;acute symptom;Address;Adult;Advanced Development;Adverse event;alertness;Animal Model;antagonist;Antidotes;Body Weight;cannabinoid receptor antagonist;Cannabinoids;Cannabis;Child;Childhood;Chocolate;clinical development;Clinical Research;CNR1 gene;Coma;Consensus;Data;Deglutition;design;Development;Dose;Drug Kinetics;effective therapy;Emergency department visit;emergency settings;Emergency treatment;Euphoria;Feeling;Formulation;Future;G-Protein-Coupled Receptors;Goals;Guidelines;Health Care Costs;Healthcare Systems;healthy volunteer;Heart Rate;Hospitalization;Hospitals;Hour;Impairment;improved;Incidence;Ingestion;Inhalation;inhibitor;Intervention;Intoxication;Intravenous;juvenile animal;Life;manufacture;marijuana legalization;marijuana use;Mediating;Medical;Nausea and Vomiting;Neurologic;Neurologic Symptoms;novel;Oral;Panic Attack;Paranoia;Patient Admission;patient population;Patients;pediatric patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Phase;phase 1 study;phase 2 study;physical symptom;preclinical study;Psychoses;receptor;Research;research clinical testing;Research Design;Risk;Safety;Sampling;Seizures;Sensory;Serious Adverse Event;Substance Use Disorder;Syndrome;synthetic cannabinoid;Tachycardia;Testing;Tetrahydrocannabinol;THC concentration;Therapeutic;Unconscious State;United States Agency for Healthcare Research and Quality;United States Food and Drug Administration;Ventilatory Depression;volunteer;Vulnerable Populations;women patients

PROJECT_TITLE: Development of an intravenous CB1 antagonist for acute cannabinoid intoxication and cannabis hyperemesis syndrome

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Methamphetamine;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: ANAHEIM

ORG_NAME: BIOCORRX PHARMACEUTICALS INC

PHR: BICX104 is a 3-month naltrexone implantable pellet for the treatment of Methamphetamine Use Disorder, alone, or in conjunction with bupropion tablets. An estimated 2 million people suffer from Methamphetamine Use Disorder and there was a 43% increase from 2015-2019. Maintaining abstinence to achieve long-term sobriety could lift patients out of methamphetamine substance abuse and have a broader impact on the societal damage of this drug.

PI_NAMEs: BEEBE DEVARNEY, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: WANG, JIA BEI

PROJECT_TERMS: Abstinence;Achievement;alcohol use disorder;Attenuated;Blood;Bupropion;Caregivers;Cessation of life;Clinical;clinical efficacy;Clinical Markers;Clinical Research;clinically relevant;comparative efficacy;Consumption;design;Dopamine;Dose;Drug Approval;Drug Kinetics;efficacy outcomes;efficacy study;efficacy testing;efficacy trial;Ensure;Epidemic;experience;FDA approved;Formulation;Half-Life;healthy volunteer;hedonic;Implant;implantation;Injections;Lifting;Methamphetamine;methamphetamine abuse;Methamphetamine relapse;methamphetamine use;Methamphetamine use disorder;Moods;Morbidity - disease rate;Naltrexone;non-compliance;Norepinephrine;Operative Surgical Procedures;Opioid;opioid use;Oral;Pathway interactions;patient population;Patients;Persons;Pharmaceutical Preparations;Phase;phase 1 study;phase 2 study;Phase Ia Clinical Trial;Phase II Clinical Trials;phase II trial;phase III trial;placebo group;Placebos;Plasma;Population;primary outcome;programs;Ramp;Reporting;reward processing;Risk;Safety;safety assessment;Signal Transduction;sobriety;Societies;Stimulant;study population;subcutaneous;Substance abuse problem;success;System;Tablets;Technology;Therapeutic;Time;treatment arm;treatment comparison;treatment group;trend;trial design;Update

PROJECT_TITLE: Efficacy, safety, and pharmacokinetic study of BICX104 naltrexone subcutaneous implant alone and in combination with bupropion for the treatment of Methamphetamine Use Disorder (MUD).


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: PSYCHIATRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Project Narrative  Looking at cardiovascular health for people living with HIV is vital given the growing number of middle- and older-aged adults living with HIV and the complex effects of HIV on cardiovascular health directly, and indirectly through HIV's impact on inflammation. Given the importance of sleep health for a range of health behaviors, including medication adherence, and the well-established link between poor sleep and increased risk for cardiovascular disease (CVD), the proposed study seeks to measure sleep, HIV health, inflammation, and cardiovascular health across a 12-month period in a sample of 240 racially-diverse sexual minority men living with HIV aged 45-64, to test pathways linking sleep to CVD risk through inflammation, and critically, through HIV health. Additionally, findings regarding the effect of daily minority stress experiences on subsequent sleep and next-day medication adherence will also provide insight into how poorer health outcomes emerge and persist in marginalized communities.

PI_NAMEs: MILLAR, BRETT M (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: actigraphy;Adherence;adherence rate;Adult;Affect;African American population;aged;Alcohol consumption;Alcohols;Anti-Retroviral Agents;Behavioral;behavioral health;Biological;Blood;Blood Pressure;C-reactive protein;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Chronic;Complex;craving;Data;diaries;Diet;Disease;Disparity;Distal;Enrollment;ethnic minority;Ethnic Origin;Exercise;experience;General Population;ghrelin;good diet;Health;Health behavior;Health Disparities Research;health disparity;Heart;Heterosexuals;High Density Lipoprotein Cholesterol;HIV;human old age (65+);Individual;Inflammation;insight;Interleukin-6;intersectionality;Leptin;life span;Link;Longitudinal, observational study;Lung;marginalization;marginalized community;marginalized population;Measures;Mediation;medication compliance;men;Mental Health;Metabolism;middle age;minority stress;minority stressor;Modeling;Obesity;Observational Study;Outcome;Pathway interactions;Pattern;Persons;Pharmaceutical Preparations;physical conditioning;Physiological;poor health outcome;poor sleep;Population;Process;protective behavior;psychologic;psychosocial;Public Health;Race;racial diversity;racial minority;Risk;Risk Factors;Role;Sampling;Self Efficacy;Sexual and Gender Minorities;sexual identity;sexual minority health research;sexual minority men;sexual minority stress;Skin;Sleep;Sleep Deprivation;Sleep Disorders;sleep health;sleep quality;social;social stigma;Source;Stress;Testing;theories;TNF gene;Tobacco;Unsafe Sex;Viral Load result;Work

PROJECT_TITLE: The Role of Sleep in Cardiovascular Health Among Men Living with HIV

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Nanotechnology;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: CARMICHAEL

ORG_NAME: THERANOSTEC, INC.

PHR: Narrative The proposed transformable Nano-Theranostics shows great promise to improve imaging sensitivity/specificity and drug delivery efficiency to HNSCC and are expected to be highly useful in precision image-guided treatment for effective detection and elimination of early localized HNSCC lesions. For larger HNSCC that require surgical resection, it can be used as a theranostic agent for (i) delineation of tumor margin for image-guided surgery, (ii) intra-operative phototherapy to treat any residual diseases at the surgical margin and adjacent sites that are accessible to illumination intra-operatively, and (iii) systemic treatment of lesions that are not accessible to illumination if using full dose anti-cancer drug within the transformable nano-theranostics. This project will significantly lower the mortality among patients with HNSCC and will have a tremendous impact on the quality of life of these patients.

PI_NAMEs: LIN, TZU-YIN  (contact)

PROGRAM_OFFICER_NAME: POND, MONIQUE ADRIANNE

PROJECT_TERMS: Acidosis;Acids;Alcohol consumption;Animal Model;anti-cancer;Antineoplastic Agents;bench-to-bedside translation;Biological;cancer cell;cancer type;Canis familiaris;Cell Line;cGMP production;Charge;Chemistry;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical translation;clinical trial readiness;Clinical Trials;commercialization;Communication;Comprehensive Cancer Center;Consultations;cost effective;Data;design;Detection;Development;Disease;Doctor of Philosophy;Dose;Doxorubicin;Drug Compounding;Drug Delivery Systems;Early Diagnosis;Epstein-Barr Virus Infections;Excision;experience;extracellular;FDA approved;first-in-human;fluorescence imaging;Foundations;Generations;Goals;Grant;Head and Neck Squamous Cell Carcinoma;Human;Human papilloma virus infection;Image;image guided;image guided intervention;image visualization;image-guided drug delivery;Image-Guided Surgery;Immunomodulators;Immunotherapy;improved;In Vitro;Infiltration;innovation;Investigation;large scale production;Lesion;Light;Lighting;Magnetic Resonance Imaging;Malignant neoplasm of nasopharynx;Malignant neoplasm of urinary bladder;Malignant Neoplasms;malignant oropharynx neoplasm;manufacture;Modality;monomer;mortality;mouse model;Multimodal Imaging;nanoformulation;nanoparticle;nanotechnology platform;nanotheranostics;Nature;Near-infrared optical imaging;Neoplasm Metastasis;novel;novel therapeutics;Operative Surgical Procedures;Organ;patient prognosis;Patients;Penetration;pharmacologic;Pharmacology and Toxicology;Phase;phase I trial;pheophorbide a;Photosensitizing Agents;Phototherapy;photothermal therapy;Procedures;Production;Prognosis;Protocols documentation;Publishing;PUVA Photochemotherapy;Quality Control;Quality of life;Radiation therapy;Rattus;Recommendation;Recurrence;Recurrent tumor;Research;Research Contracts;Residual Cancers;Residual Neoplasm;response;Risk Factors;Rodent;Safety;Sensitivity and Specificity;Site;Small Business Innovation Research Grant;Solid;Solid Neoplasm;stability testing;Structure;subcutaneous;Surgical margins;Survival Rate;System;theranostics;Therapeutic;Therapeutic Effect;Tissues;Tobacco use;Translating;tumor;uptake;Virus Diseases;Visualization;Work

PROJECT_TITLE: Transformable Theranostics for imaging-guided interventions in head and neck squamous cell carcinoma


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: This proposal addresses a critical need for both our older and younger populations of veterans. Head trauma is a risk factor for both Alzheimer disease and Chronic Traumatic Encephalopathy, a neurodegenerative disease caused by repetitive mild traumatic brain injury. Soldiers have always been at risk for head injury and this is particularly the case for OEF/OIF veterans, many of who have experienced explosive blast injury and participated in contact sports. There is a critical need to understand the mechanisms and risk factors underlying this injury to facilitate prevention, diagnosis, and treatment. The aging veteran population and high rate of head injury will lead to daunting costs and responsibilities for the VA if research aimed at translating mechanisms into biomarkers and treatments is not developed. Improved understanding of the role of cerebrovascular remodeling in the development of neurodegenerative disease may lead to new treatment options and directions for interventions.

PI_NAMEs: STEIN, THOR  (contact)

PROJECT_TERMS: Address;Age;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;anterior cerebral artery;Arteries;Atrophic;Attention;Autopsy;Behavior;Behavioral Symptoms;beta amyloid pathology;Biochemistry;Biological Markers;Biology;biomechanical test;Biomechanics;Blast Injuries;Blood;Blood - brain barrier anatomy;Blood Vessels;Brain;Brain Injuries;brain tissue;Cells;Cerebral Amyloid Angiopathy;cerebral artery;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;chronic traumatic encephalopathy;Clinical;Cognitive;cognitive function;Collagen;contact sports;cost;Craniocerebral Trauma;Data;Data Set;Dementia;Deposition;design;Development;Diagnosis;Elasticity;executive function;experience;Extracellular Matrix;Fiber;frontal lobe;Funding;glycoproteomics;Goals;head impact;Human;Immunohistochemistry;Impaired cognition;improved;informant;Injury;Intervention;Interview;Language;Mass Spectrum Analysis;Measures;Medical;Memory;Metabolism;Microcirculation;mild traumatic brain injury;military veteran;Modeling;Molecular Structure;Moods;multidisciplinary;multiphoton imaging;Myelin;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;neuropathology;optical imaging;Outcome;Pathologic;Pathology;Perfusion;Play;Predisposition;pressure;Prevention;progressive neurodegeneration;Property;protein TDP-43;Pulse Pressure;Questionnaires;Recording of previous events;Research;Resources;Risk;Risk Factors;Role;sex;Smooth Muscle Myocytes;Soldier;Stress;Structure;tau aggregation;tau Proteins;Testing;Translating;Trauma;United States National Institutes of Health;Vascular remodeling;Veterans;Visuospatial

PROJECT_TITLE: The neuropathology of mild traumatic brain injury in Alzheimer's disease


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE The relevance of this research to public health is that these trainees will be mentored in translational clinical research. This 2-year educational research experience will then be applied by these mentees in the future (long-term) to conduct meaningful research that will advance burn and trauma care.

PI_NAMEs: FINNERTY, CELESTE CAMPBELL;SUMAN-VEJAS, OSCAR E.;WOLF, STEVEN ERIC (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TITLE: Postdoctoral Training in Trauma and Burns


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Lung;Lung Cancer;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: STANFORD

ORG_DEPT: NEUROSURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: Lung cancer (LC) causes significant mortality and morbidity in the U.S. How to guide screenings for LC survivors is a critical and timely public health concern, as CT screening becomes the standard of care with increased LC survivors in the US population. From a public health perspective, our study has high impact because the completion of this study will provide a valuable decision tool for evaluating an individual’s risk of developing second primary lung cancer (SPLC) and a set of optimal screening strategies for SPLC among LC survivors, which will ultimately result in a substantial reduction of the LC mortality and, in turn, a substantial cost-savings for the healthcare system.

PI_NAMEs: HAN, SUMMER S (contact)

PROGRAM_OFFICER_NAME: MARCUS, PAMELA M

PROJECT_TERMS: Address;Adoption;Assessment tool;Behavioral;biobank;Calibration;Cancer Etiology;Cancer Patient;cancer risk;Cancer Survivor;Cessation of life;Characteristics;Clinical;clinical risk;cohort;Cohort Studies;Colorectal;computed tomography screening;Consensus;Consensus Development;Cost Savings;Data;Diagnosis;Environmental Risk Factor;Evaluation;Exclusion;follow-up;Genetic;Genetic Risk;Goals;hazard;Healthcare Systems;high risk;improved;Individual;Life;Long-Term Survivors;low dose computed tomography;Lung;lung cancer screening;Malignant neoplasm of lung;Measures;Medical History;Meta-Analysis;Modeling;models and simulation;Morbidity - disease rate;mortality;multi-ethnic;Ovarian;parent grant;Parents;Patients;Performance;Pharmacotherapy;Population;Predictive Cancer Model;predictive modeling;Preventive measure;programs;Prospective, cohort study;Prostate;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;Public Health;Risk;Risk Assessment;Risk Factors;risk prediction model;Role;Sample Size;screening;screening guidelines;Smoker;Smoking;smoking cessation;Smoking History;standard of care;Survivors;Time;tool;Translating;tumor;Uncertainty;Update;Validation

PROJECT_TITLE: Evaluation of genetic, clinical and environmental risk factors to establish effective screening strategies for second primary lung cancer


ADMINISTERING_IC: AG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Bioengineering;Genetics;Osteoporosis;Physical Activity;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOISE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOISE STATE UNIVERSITY

ORG_STATE: ID

PHR: Project Narrative This proposal is designed to examine that the loss of mechanical perception encountered in aging might be, in-part, due to decreased communication to the nucleus. The premise that intra-cellular connectivity maintained by “Linker of Nucleoskeleton and Cytoskeleton” complexes may be the key aspect regulating the nuclear mechanotransduction is of paramount interest for potential therapeutic interventions and poised to lay the foundation for novel advances in treatment and prevention of musculoskeletal decline as seen in aging, obesity, bedrest and other musculoskeletal conditions.

PI_NAMEs: UZER, GUNES  (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: Actins;Affect;Age;age related;aged;Aging;aging related;Architecture;Attenuated;Bed rest;Binding;bone;Bone Marrow;bone quality;Cell Aging;Cell Differentiation process;Cell Nucleus;Cell Physiology;Cell Proliferation;Cells;Chemicals;Chromatin;Clinical;Communication;Communities;Complex;Cytoskeleton;Data;design;disabled;Disabling;Disease;effective therapy;Effectiveness;Elements;Environment;Exercise;F-Actin;Failure;Foundations;Gene Targeting;Genes;Genetic Transcription;Health;Impaired healing;Impairment;improved;In Vitro;in vivo;Inferior;interest;Knowledge;Measures;mechanical signal;Mechanics;mechanotransduction;Mediating;Medical Care Costs;Mesenchymal Differentiation;Mesenchymal Stem Cells;mimetics;Modality;Molecular;Mus;Musculoskeletal;Musculoskeletal System;Natural regeneration;novel;Nuclear;Nuclear Envelope;Nuclear Structure;Nuclear Translocation;Obesity;old mice;Older Population;Osteogenesis;osteogenic;Osteoporosis;Perception;Phenotype;Physical activity;preservation;Prevalence;prevent;Prevention;pro-aging;Process;Proliferating;Proteins;Quality of life;Recovery;regeneration potential;regenerative;Regenerative capacity;Regenerative Medicine;Reporting;Research;response;Role;Signal Transduction;Site;skeletal;Skeleton;Source;stem cell aging;stem cell function;stem cell growth;stem cell proliferation;stem cells;Stimulus;Structure-Activity Relationship;Testing;Therapeutic Intervention;Time;Tissues;Transcriptional Regulation;Transducers;transmission process;vibration;Weight-Bearing state

PROJECT_TITLE: Role of LINC-mediated Mechanosignaling in MSC Aging

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Each day, respiratory tract surfaces are exposed to billions of potentially harmful particles whose accumulation is averted by mucus barriers that reduce particle deposition, and by white blood cells called macrophages that engulf and digest materials that get past mucus barriers. While critical for defense, dysfunction within these two systems can contribute to lung injury and to subsequent scarring of lung tissues as they heal. We have identified a critical link between mucus and macrophage functions that highlights their abilities to communicate during responses to lung injury, and our studies have the potential to significantly impact our cellular and molecular understanding of mucus and macrophage functions, while also identifying potential targets for prevention and treatment of acute lung injury and fibrosis.

PI_NAMEs: EVANS, CHRISTOPHER M (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acute;Acute Lung Injury;Address;Alveolar;alveolar epithelium;Alveolar Macrophages;Animals;Award;Bacteria;Binding;Bleomycin;Bone Marrow;Calibration;cell type;Cells;Chimera organism;Chronic;Communication;Complication;Data;Deposition;Disease;Distal;Exposure to;Fibrosis;fibrotic lung;Functional disorder;Galactose;Gases;Genes;Glycoproteins;healing;Health;Homeostasis;Host Defense;Human;Immunoglobulins;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;interest;Knockout Mice;Lectin;Leukocytes;Ligands;Ligation;Link;Lipopolysaccharides;Location;Lung;lung injury;lung repair;Macrophage;Mediating;Molecular;Molecular Conformation;molecular subtypes;monocyte;mortality;MUC5B gene;Mucins;Mucous body substance;Mus;Mutant Strains Mice;neutrophil;novel;novel strategies;Outcome;overexpression;particle;Pathogenesis;Pathologic;Pathway interactions;Patients;Physiological;Polysaccharides;Population;Positioning Attribute;prevent;Prevention;Pulmonary Fibrosis;pulmonary function;receptor;Recovery;recruit;repaired;Resolution;respiratory;Respiratory System;response;response to injury;Risk;Risk Factors;Role;Sampling;sialic acid binding Ig-like lectin;Sialic Acids;sialylation;Sialyltransferases;Signal Transduction;Signaling Molecule;Structure;Surface;System;Testing;Time;Tissues;transcriptome sequencing;Work

PROJECT_TITLE: Mechanisms of lung macrophage programming by MUC5B during health and disease

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE Pharmacokinetic (PK) drug-drug interaction (DDI) studies are rarely performed in infants, which results in the extrapolation of adult dosing recommendations that account for the DDI potential to infants despite known age- induced physiological changes that can alter the DDI magnitude with age. By incorporating information about the DDI mechanism and physiological age-induced changes that affect the DDI magnitude, physiologically-based pharmacokinetic (PBPK) models can be used to predict PK DDIs in infants. This proposal will evaluate a systematic approach to PK DDI evaluation in infants using PBPK modeling and real-world data to accelerate the availability of age-appropriate drug dosing recommendations for infants in light of the DDI potential.

PI_NAMEs: GONZALEZ, DANIEL  (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: 2 year old;Acceleration;Adult;Advocate;Affect;Age;age related changes;Childhood;Clinical Pharmacology;Clinical Trials;Collection;CYP2C9 gene;CYP3A4 gene;cytochrome P450 3A;Data;Data Collection;Dedications;Dependence;Doctor of Pharmacy;Doctor of Philosophy;dosage;Dose;Drug Addiction;Drug Combinations;drug development;Drug Interactions;Drug Kinetics;drug metabolism;Drug Metabolism Inhibition;Drug Modelings;Enrollment;Environment;Enzymes;Ethics;Evaluation;Fellowship;Fentanyl;Fluconazole;fosphenytoin;Goals;Hospitalization;Infant;Infrastructure;inhibitor;Intervention;knowledge integration;Life;Light;Mediating;Medical;Metabolism;Midazolam;National Institute of Child Health and Human Development;Patients;pediatric drug development;Pharmaceutical Preparations;pharmacokinetic model;Phenobarbital;Phenytoin;Physiological;Postdoctoral Fellow;predictive modeling;Principal Investigator;prospective;Public Health;Recommendation;Recording of previous events;Regimen;Research;Risk;Science;skills;standard of care;tool;Toxic effect;Training;unethical;Valproic Acid;volunteer

PROJECT_TITLE: Application of Physiologically-Based Pharmacokinetic Modeling to Characterize Drug-Drug Interactions in Infants


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: BINGHAMTON

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Prenatal alcohol and anxiety: an ontogenetic role for CRF Prenatal exposure to alcohol differential affects anxiety across the lifespan and increases ethanol consumption, yet the neurobiological underpinnings are not well understood. The corticotropin- releasing factor (CRF) system is heavily involved in regulating anxiety and ethanol intake through its actions in the medial central amygdala (CeM) and is disrupted by prenatal exposure to alcohol. This proposal will examine prenatal alcohol-induced adaptations in the CRF system within the CeM across ontogeny to determine how dynamic changes in this system contribute to fluctuations in anxiety-like behaviors and ethanol intake.

PI_NAMEs: DIAZ, MARVIN RAFAEL (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Acute;Adolescent;adolescent alcohol exposure;adolescent offspring;Adult;Adult women;Affect;Age;age related;Agonist;Alcohol abuse;alcohol abuse during pregnancy;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol use disorder;Alcohols;Amygdaloid structure;Anti-Anxiety Agents;Anxiety;Anxiety Disorders;anxiety-like behavior;anxiety-related behavior;Behavior;Behavioral;Blood;Brain;Brain region;Cells;Central Medial Thalamic Nucleus;Child;Childhood;Corticotropin-Releasing Hormone;Coupling;Data;Development;Electrophysiology (science);Emotional;epidemiologic data;Ethanol;Exposure to;Female;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;gamma-Aminobutyric Acid;Growth;GTP-Binding Proteins;Human;Impairment;In Vitro;in vivo;Individual;Infusion procedures;innovation;Investigation;Life;life span;Long-Term Effects;male;Male Adolescents;Marble;Measures;Medial;Mediating;Messenger RNA;Microinjections;Modeling;neurobiological mechanism;Neurobiology;neurogenesis;neuromechanism;novel;novel therapeutic intervention;offspring;Pathway interactions;Pattern;Phase;Phenotype;Population;preference;Pregnancy;prenatal;Prevalence;Proxy;Rattus;receptor;Risk Taking;Role;sex;Sex Differences;showing emotion;Signal Transduction;Site;Stress;Structure;Synapses;Syndrome;System;Testing;Time;transmission process;vapor

PROJECT_TITLE: Prenatal Alcohol and Anxiety: An Ontogenetic Role for CRF

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Cancer;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PUBLIC NARRATIVE Ovarian cancer has a unique metastatic pattern and stromal cells including cancer-associated fibroblasts (CAFs) play a key role in the metastatic process. I aim to study the role of omental CAF Discoidin domain receptor 2 (DDR2) in cancer cell metastasis, especially through its regulation of arginase-1. This study will uncover novel mechanisms by which omental CAF DDR2 and arginase alter collagen remodeling and polyamine biosynthesis, and may support development of novel therapies for ovarian cancer patients in the future.

PI_NAMEs: AKINJIYAN, FAVOUR AYOMIDE (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Abdomen;Anabolism;Architecture;arginase;Arginine;Biological Assay;cancer cell;Cancer Patient;Cell Proliferation;Cells;Chemoresistance;Collagen;Data;Deposition;Development;Diffusion;discoidin domain receptor 2;Environment;Enzymes;Extracellular Matrix;Female Genital Diseases;Fibrillar Collagen;Fibroblasts;Future;Greater sac of peritoneum;Growth;Human;In Vitro;in vivo;intraperitoneal;Knock-out;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuscripts;Mass Spectrum Analysis;Mediating;Mesenchymal;Mesothelial Cell;Mesothelium;Metabolic;metastatic process;Molecular;mouse model;mRNA sequencing;Mus;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Omentum;Organ;Ornithine;Ornithine Decarboxylase;Ovarian;ovarian neoplasm;overexpression;paracrine;Pattern;Peritoneal;Physicians;Play;Polyamines;Production;Proline;receptor binding;Receptor Protein-Tyrosine Kinases;Regulation;response;Role;Scientist;Serous;small hairpin RNA;Source;Stage at Diagnosis;Stromal Cells;Stromal Neoplasm;Testing;therapeutic development;Therapeutic Intervention;Training;treatment response;tumor;Tumor Burden;Tumor Cell Invasion;tumor growth;tumor microenvironment

PROJECT_TITLE: The action of DDR2 in cancer-associated fibroblasts promotes ovarian cancer metastasis through increased arginase-1 activity.


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Cerebrovascular;Endocannabinoid System Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Therapeutic Cannabinoid Research;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Traumatic Brain Injury (TBI) is a leading cause of injury related death and disability in the United States for which there are no currently approved pharmacological treatments. A hallmark of TBI is vascular injury which greatly disrupts neuronal networks leading to deficits in brain function. This proposal explores the importance of the Cannabinoid 2 Receptor (CB2) as a druggable target for vascular protection following TBI.

PI_NAMEs: BULLOCK, TRENT A (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Abnormal coordination;Address;Affinity;age group;Agonist;Alzheimer's disease risk;Area;Attenuated;Behavioral;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier crossing;blood-brain barrier disruption;blood-brain barrier function;Brain;brain endothelial cell;Cannabinoids;Cell Adhesion Molecules;Centers for Disease Control and Prevention (U.S.);Cerebral endothelium;cerebral microvasculature;cerebrovascular;Cerebrovascular system;Clinical;CNR1 gene;CNR2 gene;cognitive development;controlled cortical impact;cytokine;Data;disability;druggable target;Effectiveness;Emotional;endogenous cannabinoid system;Endothelial Cells;Endothelium;Evaluation;Executive Dysfunction;Exhibits;Functional disorder;Gene Expression Profiling;Genes;Goals;Government;Head;Homeostasis;Imaging Techniques;Immune;immune function;Impaired cognition;improved;In Vitro;in vivo;in vivo Model;Incidence;Inflammation;Inflammatory;Inflammatory Response;Injury;injury-related death;insight;Kinetics;Lipopolysaccharides;Modeling;Molecular;nanomolar;Nervous System Trauma;neurobehavioral;Neuroimmune;neuroinflammation;Neurologic;Neurons;Neuropsychology;novel;Pathology;Pathway interactions;Penetrating Brain Injury;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Prevalence;Property;protein expression;receptor;Receptor Activation;receptor expression;Receptor Signaling;Recovery;repaired;Reporting;Research;Resolution;response;response to injury;Role;side effect;Solubility;Stretching;Substance Use Disorder;systemic inflammatory response;TBI treatment;Testing;Therapeutic;therapeutic target;therapeutically effective;Tight Junctions;Time;Traumatic Brain Injury;United States;Up-Regulation;vascular injury

PROJECT_TITLE: The role of Cannabinoid Receptor 2 in cerebrovascular protection following traumatic brain injury


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Heart Disease;Organ Transplantation;Pediatric;Precision Medicine;Transplantation

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Immunosuppressive therapy is required to prevent organ rejection, however, dosing of immunosuppressive agents is complicated by patient-specific differences impacting the body’s absorption and elimination of these agents. The goal of this research proposal is to clinically validate an innovative precision medicine strategy for dosing the immunosuppressant tacrolimus in pediatric heart transplant, which will in turn lead to improvements in long-term transplant survival outcomes. The strategy and techniques used in this project can be extended to improve drug therapy across multiple pediatric diseases requiring chronic therapy.

PI_NAMEs: ROWER, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: absorption;Age;antibody-mediated rejection;Biological Markers;Biometry;Cardiomyopathies;career;Cessation of life;Child;Childhood;Chronic;Clinical;Clinical Research;congenital heart abnormality;Creatinine clearance measurement;CYP3A5 gene;Data;Decision Making;Disease;Dose;Drug Kinetics;Drug Monitoring;Enrollment;Genetic;genetic variant;Genetic Variation;Genotype;Goals;Health;Heart;Heart Transplantation;Hepatic;Immunosuppression;Immunosuppressive Agents;improved;improved outcome;Individual;innovation;Kidney;Knowledge;Longevity;Maintenance;Measures;Mentors;metabolomics;Modeling;Modification;Nature;organ transplant rejection;Organ Transplantation;Outcome;patient population;Patients;Pediatric Research;Pharmaceutical Preparations;pharmacodynamic biomarker;pharmacodynamic model;Pharmacogenetics;Pharmacogenomics;pharmacokinetic model;Pharmacology;Pharmacotherapy;Population;Population Control;post-transplant;precision medicine;prevent;Process;prospective;Publications;Research;Research Proposals;Safety;Sampling;skill acquisition;skills;success;survival outcome;Tacrolimus;targeted biomarker;Techniques;Testing;Therapeutic Effect;Therapeutic immunosuppression;Time;tool;Training;Transplant Recipients;Transplantation;Treatment-related toxicity

PROJECT_TITLE: Precision Pharmacokinetic-Guided Tacrolimus Dosing to Improve Pediatric Heart Transplant Outcomes

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The Penn Training Program in Rheumatic Diseases will provide the infrastructure and outstanding opportunities required to develop the next generation of physicians and scientists prepared to address the need to continue to close our knowledge gaps about basic pathophysiology, diagnosis, epidemiology, outcomes, and treatment of rheumatic diseases in all their manifestations. The program’s goal is to provide a rich, multi-disciplinary, multi- modal training environment to support the success of developing trainees in becoming independent scientists dedicated research in Rheumatic Disease. This program builds upon many decades of excellent success by the Penn/CHOP Adult and Pediatric Rheumatology Divisions in training leading researchers in Rheumatology.

PI_NAMEs: BEHRENS, EDWARD M;MERKEL, PETER A (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Rheumatism;Training Programs

PROJECT_TITLE: Training Program/Rheumatic Diseases