NIH_SPENDING_CATS: Genetics;Hematology;Human Genome;Orphan Drug;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Narrative Proper control of ribosome biogenesis and protein synthesis in hematopoietic stem and progenitor cell populations is crucial to hematopoiesis and suppression of blood-derived cancers, as prominently illustrated by a cluster of bone marrow syndromes called “ribosomopathies” in humans. The overall goal of this research program is to better understand the regulation of ribosome assembly and protein translation processes by ubiquitination of critical ribosome assembly factors that is important for preventing stem cell attrition and translation abnormalities. Our studies will provide new insights into stem cell transplantation and therapeutic strategies for treatment of various blood cell disorders.

PI_NAMEs: TONG, WEI  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Affect;Alleles;Allogenic;Biochemical;Biogenesis;Biological;Blood;Blood Cells;Bone Marrow;Bone marrow failure;bone marrow failure syndrome;Bone Marrow Transplantation;cancer predisposition;cell growth;Cell Line;Cell Maintenance;Cell Physiology;Cells;Clinical;Clinical Treatment;Collaborations;conditional knockout;Cytoplasm;Data;Defect;Disease;epigenomics;Etiology;Exhibits;exome sequencing;Failure;Functional disorder;Genes;Genetic;genetic analysis;Genetic Suppression;Genomics;Germ Lines;Goals;Growth;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Human;in vivo;insight;interest;knock-down;Knockout Mice;lentivirally transduced;Link;Malignant Neoplasms;Marrow;Mediating;Mutation;Myeloproliferative disease;novel;novel therapeutic intervention;novel therapeutics;Pathway interactions;Patients;polypeptide;Polyribosomes;Predisposition;prevent;programs;Prokaryotic Cells;Protein Biosynthesis;Proteins;Proteomics;reconstitution;Registries;Regulation;Research;Ribosomal Proteins;ribosome profiling;Ribosomes;ribosomopathy;Role;self-renewal;Shwachman-Diamond syndrome;Signal Transduction;small hairpin RNA;stem cell function;stem cell population;Stem cell transplant;stem cells;Structure;Syndrome;Testing;Therapeutic;Therapeutic Intervention;transcriptome;transcriptome sequencing;Translation Process Protein;Translations;Transplantation;treatment strategy;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Validation;Yeasts

PROJECT_TITLE: Regulation of  Ribosome Biogenesis in Hematopoietic Stem Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(02)M]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: CAMBRIDGE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE Cancer is a disease of the genome and arises due an accumulation of mutations that drive normal cells to become cancerous. As a Genome Data Analysis Center (GDAC) with expertise in discovering and characterizing point mutations in the cancer genome, we aim to integrate our state-of-the-art rigorous tools and pipelines for robust point mutation characterization and driver discovery into the Genome Data Analysis Network (GDAN) alongside other GDACs with expertise in complementary fields. Understanding the significance of the point- mutation drivers in the context of analyses from other GDACs in the GDAN will provide the cancer field with a deep, comprehensive understanding of many cancer types that can inform future clinical therapeutics and advance precision medicine at the single-patient level.

PI_NAMEs: GETZ, GAD A (contact);RHEINBAY, ESTHER

PROGRAM_OFFICER_NAME: YANG, LIMING

PROJECT_TERMS: Address;Aftercare;Biological;Biopsy;Blood;Cancer Biology;cancer genome;cancer genomics;Cancer Patient;cancer subtypes;cancer type;Cancerous;cell free DNA;Cells;Clinical;Clinical Data;Code;cohort;Collaborations;Competence;Complex;Computational Biology;Data;Data Analyses;Data Set;Dedications;Diagnosis;Disease;DNA;DNA Methylation;DNA Sequence Alteration;driver mutation;Epigenetic Process;epigenome;Event;Evolution;flexibility;Future;Genes;Genetic;Genome;genome analysis;Genome Data Analysis Center;Genome Data Analysis Network;genome sequencing;Genomic Data Commons;Genomics;Goals;Heterogeneity;improved;Individual;innovation;insertion/deletion mutation;interest;International;Journals;Knowledge;Machine Learning;Malignant Childhood Neoplasm;Malignant Neoplasms;Messenger RNA;Methods;Methylation;Microsatellite Repeats;Molecular Abnormality;Mutation;Mutation Analysis;neoantigens;next generation;Normal Cell;novel;Nucleotides;Oncogenes;Outcome;Paper;Pathway interactions;Patients;Pattern;personalized medicine;Play;Point Mutation;precision medicine;predictive modeling;Process;Production;Prognosis;promoter;Publishing;Quality Control;rare cancer;Regulatory Element;Repetitive Sequence;Research;Resistance;resistance mechanism;RNA;Role;Sample Size;Sampling;single-cell RNA sequencing;subclonal heterogeneity;targeted treatment;Techniques;The Cancer Genome Atlas;Therapeutic;therapeutic target;therapeutically effective;Tissues;tool;translational oncology;translational scientist;tumor;Untranslated RNA;Variant;whole genome;Work;working group

PROJECT_TITLE: Comprehensive analysis of point mutations in cancer


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: WALTHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative Relevance: Cognitive deficits involving memory are a common symptom of several neuropsychiatric disorders, and the inability to associate hedonic value of food and tastes with the appropriate context is also implicated in eating disorders. This project aims to understand mechanisms underlying neural coordination at the network level between the sensory cortical region that mediates taste perception and decisions, and the hippocampus which mediates formation and recall of episodic memories. This research will enable novel insight into physiological mechanisms that govern the ability to form and recall memories of taste experiences, and help us to develop tools for tackling cognitive deficits related to memory and eating disorders.

PI_NAMEs: JADHAV, SHANTANU P (contact);KATZ, DONALD B

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Address;Animals;awake;Behavior;Behavioral;Cells;Code;Cognitive;Cognitive deficits;common symptom;Consumption;Coupling;Data Set;Decision Making;Desire for food;Development;Eating Disorders;Electrophysiology (science);entorhinal cortex;Environment;Episodic memory;experience;experimental study;Fiber Optics;Food;Foundations;Goals;hedonic;Hippocampus;Impairment;Implant;individual response;insight;Lateral;Learning;Location;Maps;Mediating;member;Memory;Memory Disorders;memory recall;neural;Neurons;neuropsychiatric disorder;novel;Optics;optogenetics;Physiological;Play;Prefrontal Cortex;Procedures;Process;Psyche structure;Rattus;Research;response;Rewards;Role;Sampling;sensory cortex;Services;Shapes;Site;Source;source localization;spatial memory;Stimulus;Taste Perception;taste stimuli;taste system;Testing;tool;Virus

PROJECT_TITLE: Hippocampal - gustatory cortical interactions underlying formation of taste-space cognitive maps

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Natural Products

ORG_CITY: AMHERST

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Despite the clear importance of plant terpenoids in medicine and everyday life, how plants synthesize these biologically active compounds remains largely unknown. This research program aims to quickly identify plant terpenoid pathways and to achieve their cost-effective production in microbes. The relevance of this research to public health is its potential to transform the production of existing plant-based medicines while generating novel medicines to treat human diseases.

PI_NAMEs: WANG, ZHEN  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Plant terpenoids: Deciphering metabolic pathways and improving production in microbes


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Mental Health;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Efficacious interventions for adolescent loss of control eating and overeating are urgently needed given their adverse impacts on weight outcomes and psychosocial functioning. Existing interventions, while promising, fail to comprehensively address self-regulation factors that may impede optimal adherence/behavior change, have modest effects on weight, and can be costly, time/resource intensive, and inaccessible to many adolescents in need. The aim of this small R01 is to design and pilot test a novel technology-based, user-informed, and potentially scalable cognitive-behavioral intervention for adolescents with or at risk for overweight or obesity, built around evidence-based self-regulation theories of maladaptive eating, which has potential to alleviate public health burdens incurred by eating- and weight-related problems.

PI_NAMEs: GOLDSCHMIDT, ANDREA BETH (contact);GRAHAM, ANDREA KASS

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Adherence;Adolescence;Adolescent;Adult;adult obesity;Affect;Affective;Aftercare;Age;aged;Area;arm;Behavior;behavior change;Behavioral;Body mass index;Body Weight;Cardiovascular Diseases;Cellular Phone;Childhood;Chronic;Clinical;Cognitive Therapy;Consumption;cost;design;Development;dietary;digital;digital delivery;digital intervention;discrete time;Distress;Eating;Eating Behavior;Eating Disorders;efficacious intervention;Evaluation;evidence base;excessive weight gain;Feedback;Feeling;follow-up;Food;food environment;Frequencies;Future;Health;Height;high risk;High Risk Woman;Hyperphagia;Impairment;improved;Informal Social Control;Internet;Intervention;Intervention Trial;Learning Skill;Link;loss of control over eating;medical specialties;Mental Health;Methods;metropolitan;Needs Assessment;new technology;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Online Systems;optimal treatments;Outcome;Overweight;Pattern;peer;Phase;Phenotype;Physiological;pilot test;preference;prevent;Process;prototype;psychosocial;Public Health;Randomized, Controlled Trials;Regulation;Reporting;Research;Research Activity;Resources;response;Risk;Role;Scientific Advances and Accomplishments;Self-control as a personality trait;sex;Site;skills;Standardization;Technology;Teenagers;Testing;Theoretical model;theories;Therapeutic Intervention;Time;Treatment outcome;treatment response;treatment strategy;Update;usability;user centered design;Weight;Weight Gain;weight gain prevention;Weight maintenance regimen;Work;young woman;Youth

PROJECT_TITLE: Designing a mobile intervention for dysregulated eating and weight gain prevention in adolescents

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Immunotherapy has become a powerful tool against cancer, but most patients who are treated with immunotherapy, by checkpoint blockade, cellular therapies, vaccination or other strategies, do not respond. The proposed research seeks to better understand what happens in tumors when we treat patients with immunotherapy. By studying tumors directly from patients at multiple timepoints during treatment with immunotherapy, and by using modern comprehensive techniques to do so, this proposal will add significantly to our current knowledge and highlight avenues for new improved immunotherapy strategies that work in more patients and in more types of cancer.

PI_NAMEs: SHREE, TANAYA  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Aftercare;Agonist;analytical method;analytical tool;anti-tumor immune response;Apoptosis;B-Cell Antigen Receptor;B-Cell Neoplasm;Bioinformatics;Biological Assay;Biomedical Research;Biometry;Biopsy;Blood specimen;breast cancer survival;cancer cell;cancer genomics;cancer immunotherapy;Cancer Patient;cancer type;career development;CD4 Positive T Lymphocytes;Cell Communication;Cell Therapy;cell type;Cells;chemotherapy;Clinical;Clinical Trials;Collection;Complement;Complex;complex data;Core Biopsy;Data;Data Set;Development;Distal;Distant;Doctor of Philosophy;effector T cell;Evolution;Exhibits;experience;Experimental Models;fighting;Follicular Lymphoma;Future;Gene Expression;Gene Expression Profile;Generations;Goals;Helper-Inducer T-Lymphocyte;high dimensionality;Histologic;Histology;Human;Immune;immune checkpoint blockade;immune health;Immune response;immune stimulant;Immune system;Immunologics;Immunology;Immunotherapy;immunotherapy trials;improved;in situ vaccination;Inflammatory Response;inhibitor;innovation;insight;Investigation;Knowledge;Link;longitudinal analysis;Low Dose Radiation;Lymphoma;Macrophage;Malignant Neoplasms;Measures;medical schools;Mentors;Minority;Modernization;Mus;neoplastic cell;novel;novel therapeutic intervention;Oncology;OX40;Pathway interactions;patient subsets;Patients;Phenotype;Phosphotransferases;Physicians;Population;Pre-Clinical Model;preclinical study;programs;Regulatory T-Lymphocyte;Research;research and development;Research Personnel;response;Sampling;Scientist;single cell genomics;Site;skills;spatial relationship;Sum;Survivors;T cell clonality;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;Testing;Time;tool;Training;transcriptome;transcriptomics;Travel;Treatment Efficacy;treatment response;tumor;Tumor Immunity;tumor microenvironment;Tumor Tissue;Tumor-associated macrophages;Universities;Vaccination;Work

PROJECT_TITLE: Dynamic Analysis of Tumor and Microenvironment in Patients Undergoing Immunotherapy

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MADISON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE STATEMENT: Voice disorders affect an estimated 3-9% of Americans yearly and 29% of the population in their lifetime. Treatment for vocal fold scarring, a voice disorder caused by tissue injury or loss has been limited. In this application, we seek to link single-cell RNA sequencing and spatial transcriptomics, at exceptional resolution, to characterize VF morphogenesis across time, location and cellular compartments and in response to injury. Whereby, providing a novel and fundamental approach for improving our understanding of VF health and disease, and will allow for optimization of engineering processes.

PI_NAMEs: THIBEAULT, SUSAN LYNN (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Affect;American;Architecture;Area;Atlases;Attention;Biology;Body System;cell type;Cells;Chemicals;Cicatrix;Collaborations;Complex;Data;Defect;design;Development;Developmental Biology;Disease;Dysphonia;Embryo;Engineering;engineering design;Epithelial Cells;Event;Fibroblasts;Funding;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Transcription;Goals;healing;Health;Heterogeneity;High-Throughput Nucleotide Sequencing;Human;human induced pluripotent stem cells;Immune;improved;Injury;injury and repair;innovation;Investigation;Knowledge;Larynx;life span;Link;Location;Maintenance;Maps;mechanical signal;Methods;Modeling;Molecular Profiling;Morphogenesis;Morphology;Mucous Membrane;multidisciplinary;Mus;Natural regeneration;next generation sequencing;novel;Operative Surgical Procedures;Pathway interactions;Population;Population Distributions;postnatal development;precursor cell;prenatal;prevent;Process;programs;repaired;replacement tissue;Research;Resolution;response to injury;single-cell RNA sequencing;skills;Spatial Distribution;spatiotemporal;Specific qualifier value;Statistical Data Interpretation;stem cell biology;stem cell differentiation;Technology;Therapeutic;Time;Tissue Engineering;tissue injury;tissue regeneration;Tissues;tool;transcriptome;transcriptomics;Treatment outcome;Validation;Variant;vocal cord;Voice Disorders;Work

PROJECT_TITLE: Engineering the Vocal Fold Mucosa

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Overall: Project Narrative This SPORE is uniquely poised to provide the expertise and infrastructure to rapidly advance sarcoma research, specifically in leiomyosarcoma (LMS), so that patient outcomes can be improved. Sarcomas like leukemias and lymphomas, are mesodermal malignancies and carry biological significance disproportionate to their clinical prevalence. The pathogenic germline variants in LMS are similar in frequency to many common epithelial cancers and our studies will lead to new insights into diagnosis and treatment not only in LMS but more common cancers as well.

PI_NAMEs: FLETCHER, JONATHAN ALFRED;SCHUETZE, SCOTT MICHAEL (contact)

PROGRAM_OFFICER_NAME: UJHAZY, PETER

PROJECT_TERMS: Acceleration;Achievement;Affect;Age;anti-cancer research;Autonomic nervous system;Behavior;Biological;Biological Markers;Biology;Black American;Blood Vessels;bone;Bone Tissue;Cancer Biology;cancer genetics;cancer predisposition;Carcinoma;career;Cervix Carcinoma;Cessation of life;Chromosomal Instability;Clinic;Clinical;clinical biomarkers;Clinical Research;clinically relevant;Combined Modality Therapy;Communities;Complex;data resource;Databases;Dedifferentiated Liposarcomas;Detection;Development;Diagnosis;Disease;Distant Metastasis;DNA Repair;DNA Repair Gene;DNA-dependent protein kinase;Dose;Doxorubicin;drug development;Economics;effective therapy;Epidemiology;Esophageal carcinoma;Evolution;Frequencies;Gastrointestinal Stromal Tumors;Gastrointestinal tract structure;Gene Mutation;gene repair;Genes;Genetic;genetic epidemiology;Genomics;Germ Lines;Germ-Line Mutation;Glioma;Goals;Heart;Hodgkin Disease;Image;Imatinib;improved;improved outcome;Incidence;Infrastructure;insight;Institution;Investigation;Knowledge;Laboratory Finding;leiomyosarcoma;leukemia/lymphoma;Li-Fraumeni Syndrome;Limb structure;liquid biopsy;Liver;Malignant Breast Neoplasm;Malignant Fibrous Histiocytoma;Malignant Neoplasms;Metastatic Neoplasm to the Lung;Microscopic;multidisciplinary;Multiple Myeloma;Muscle;Mutate;Mutation;Myxoid Malignant Fibrous Histiocytoma;Names;Necrosis;novel strategies;novel therapeutics;older adult;Organ;Pathogenesis;Pathogenicity;Pathologic;patient biomarkers;Patient-Focused Outcomes;Patients;peripheral blood;personalized medicine;Phase I/II Trial;Plasma;Population;precursor cell;Prevalence;Prognosis;prognostic;programs;Public Health;Quality of life;rare cancer;Recording of previous events;Reporting;Research;research study;resistance mechanism;response;Retroperitoneal Space;Risk;Role;Sarcoma;Secondary to;SEER Program;Signal Pathway;Site;Smooth Muscle;Smooth Muscle Myocytes;Soft tissue sarcoma;Solid Neoplasm;Somatic Mutation;success;Susceptibility Gene;targeted treatment;Technology;Testicular Carcinoma;Therapeutic;therapeutic target;TP53 gene;Translating;translational impact;Translational Research;tumor;Tumor Burden;tumor heterogeneity;tumorigenesis;Uterine Leiomyosarcoma;Uterus;Variant;Woman;women patients;Women's prevalence

PROJECT_TITLE: Genetics and Genomics of Leiomyosarcoma (LMS): Improved understanding of cancer biology and new approaches to diagnosis and treatment


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Rare Diseases

PI_NAMEs: SCHUETZE, SCOTT MICHAEL (contact)

PROJECT_TERMS: Accounting;Address;Advocate;Award;Awareness;Biology;Cancer Biology;Cancer Center;cancer clinical trial;cancer genetics;cancer predisposition;cancer prevention;career;Clinic;Clinical;Clinical Research;clinical translation;Clinical Trials;Clinical Trials Support Unit;Collaborations;Committee Membership;Communication;Comprehensive Cancer Center;data sharing;Development;Diagnosis;Disease;diversity and inclusion;DNA Repair;Ensure;expectation;experience;Eye;flexibility;Foundations;Funding;Genetic;Genomics;Germ-Line Mutation;Goals;Grant;Group Meetings;improved;Infrastructure;innovation;Institution;Internal Medicine;Knowledge;Laboratories;Leadership;leiomyosarcoma;Liquid substance;Malignant Fibrous Histiocytoma;Medical Oncologist;medical schools;Medicine;meetings;member;Michigan;mid-career faculty;Mission;Monitor;multi-site trial;novel strategies;operation;Osteosarcoma;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Persons;Physician Executives;Positioning Attribute;Principal Investigator;professor;prognostic;programs;Progress Reports;Publications;radiologist;recruit;Research;Research Personnel;Research Project Grants;Resources;Sarcoma;Science;Scientist;Site;skills;Soft tissue sarcoma;Southwest Oncology Group;Structure;Susceptibility Gene;TP53 gene;translational goal;Translational Research;translational scientist;Tumor Markers;Underrepresented Populations;United States National Institutes of Health;Universities;Voice;webinar;Work

PROJECT_TITLE: Core A: Administrative Core


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: THE CANCER CELL MAP INITIATIVE v2.0 OVERALL NARRATIVE Although much attention has been devoted to mapping the tumor genome, understanding cancer requires that we move beyond simply cataloguing the genes associated with it. It is critical to understand the many interactions among these genes and the corresponding proteins, and how these complex networks give rise to tumor initiation, progression and metastasis. The Cancer Cell Map Initiative (CCMI) is applying systematic approaches to comprehensively map the molecular networks that underlie cancer and to use these maps as key resources for precision medicine.

PI_NAMEs: IDEKER, TREY ;KROGAN, NEVAN J (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Advanced Malignant Neoplasm;anti-cancer research;Area;Atlas of Cancer Mortality in the United States;Attention;Binding;Bioinformatics;Biological Assay;Biology;Breast;California;cancer cell;Cancer Center;cancer genome;Cataloging;Catalogs;Cell Line;cell motility;Cell Proliferation;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;combinatorial;Complex;computerized tools;Copy Number Polymorphism;Cryoelectron Microscopy;Data;deep learning;Dependence;Disease;driver mutation;drug response prediction;experimental study;Expert Systems;Faculty;FDA approved;Funding;Gene Mutation;Genes;Genetic Diseases;Genetic Screening;genome-wide;Head and Neck Neoplasms;Heterogeneity;Image;Immunofluorescence Microscopy;Information Networks;Institution;interest;knockout gene;Laboratories;Logic;Lung;Malignant Neoplasms;Maps;Mind;Mission;Modeling;Molecular;molecular modeling;mouse model;Mutation;NCI Center for Cancer Research;Neoplasm Metastasis;neoplastic cell;next generation;Other Genetics;Pathogenesis;Pathway interactions;patient response;Patients;Pattern;personalized medicine;Phenotype;Physiological;PIK3CA gene;Point Mutation;precision medicine;precision oncology;pressure;Principal Investigator;Proliferating;protein complex;Proteins;rare cancer;Research Personnel;Resources;scale up;Science;Scientist;simulation;Sister;spatiotemporal;Squamous Cell;Structural Models;Structure;System;Systems Biology;Techniques;The Cancer Genome Atlas;Time;TP53 gene;Training;training opportunity;transfer learning;Translating;treatment response;tumor;tumor initiation;Universities

PROJECT_TITLE: The Cancer Cell Map Initiative v2.0


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Orphan Drug;Rare Diseases

PHR: Project 1: Narrative Project 1 seeks to develop therapies that maximize intrinsic LMS genotoxic stress by targeting the key DNA damage response enzyme, DNA protein kinase. We have shown that most LMS have chromosomal instability (CIN) which creates hyper-dependence on this enzyme. The initial clinical trial in this Project tests the hypothesis that a very low dose of doxorubicin sensitizes LMS cells to DNA-PKi and PARPi, thereby converting CIN into a liability while minimizing nonneoplastic cell toxicity.

PI_NAMEs: FLETCHER, JONATHAN ALFRED (contact)

PROJECT_TERMS: Address;Aftercare;Biochemical;Biological;Biological Assay;Biological Markers;Biopsy;Cancer Biology;Cell Line;Cells;chemotherapy;Chromosomal Instability;Clinical;clinical translation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Compensation;Coupled;CRISPR interference;CRISPR screen;CRISPR-mediated transcriptional activation;Cytotoxic agent;Cytotoxic Chemotherapy;Data Analyses;Defect;Dependence;Diagnosis;DNA;DNA Damage;Dose;Doxorubicin;ds-DNA;Enzymes;Essential Genes;Evaluation;Event;Family;gene repression;Genes;Genetic;Genetic Transcription;genomic profiles;Genomics;Genotoxic Stress;genotoxicity;Goals;Guide RNA;Heterogeneity;homologous recombination;improved;In Vitro;inhibitor;inhibitor therapy;insight;Investigational Therapies;leiomyosarcoma;Libraries;Mediating;member;Metastatic Leiomyosarcoma;Minority;Modeling;Molecular;Mus;Mutation;Neoplasm Metastasis;novel strategies;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphotransferases;PIK3CG gene;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Pre-Clinical Model;preclinical study;predicting response;Protein Kinase;protein kinase inhibitor;Proteins;RB1 gene;repaired;Reproducibility;Resistance;resistance mechanism;Resources;response;Safety;Sarcoma;Science;Specimen;targeted treatment;Testing;Therapeutic;therapy development;Time;Toxic effect;TP53 gene;transcriptome sequencing;Validation;validation studies

PROJECT_TITLE: PROJECT 1:  Genomic Vulnerabilities in Leiomyosarcoma (LMS)


NIH_SPENDING_CATS: Cancer

PI_NAMEs: KROGAN, NEVAN J (contact)

PROJECT_TERMS: Address;Administrator;Advisory Committees;Agreement;anti-cancer research;Area;Budgets;cancer cell;Catalogs;Cells;Collaborations;Communication;Communities;Complement;Custom;Data;data interoperability;Data Set;data sharing;diversity and inclusion;Documentation;Education;Educational Status;Ensure;Equilibrium;Event;Faculty;Funding;Gender;Goals;high risk;innovation;Institution;interest;Journals;Link;Malignant Neoplasms;Maps;meetings;member;Mission;Monitor;Nature;network models;outreach;Pilot Projects;Productivity;programs;Publications;Qualifying;Research;Research Personnel;Resource Sharing;Resources;response;San Francisco;Schedule;Science;Scientist;Secure;software infrastructure;Software Tools;Systems Biology;Talents;Training;United States National Institutes of Health;web portal;web site;Woman;working group

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Genetics;Human Genome;Neurodegenerative;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Local instability of short tandem repeat tracts causes severe pathologic disruption of multiple cell types and organ systems in a cohort of trinucleotide repeat expansion disorders. To inform new therapies, we seek to understand the functional link between repeat expansion and higher-order chromatin folding patterns in the nucleus of pathologically affected cell types at a single-cell resolution.

PI_NAMEs: JAIN, RAJAN ;JOYCE, ERIC F.;LAKADAMYALI, MELIKE ;PHILLIPS-CREMINS, JENNIFER ELIZABETH (contact);VAHEDI, GOLNAZ

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: 3-Dimensional;Affect;Amyotrophic Lateral Sclerosis;Architecture;Biological Assay;Biological Models;Body System;Carbon;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cell Nucleus;cell type;Cells;cellular imaging;Chromatin;Chromatin Structure;chromosome conformation capture;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;CpG Islands;Data;density;derepression;Disease;Dissection;DNMT3a;Engineering;Epigenetic Process;Etiology;Event;Exhibits;Exons;Fibrosis;FMR1 gene;Fragile X Syndrome;frataxin;Friedreich Ataxia;Functional disorder;gallium arsenide;Gene Expression;Gene Silencing;Genes;Genetic Transcription;Genome;Genome engineering;Genome Mappings;genome-wide;genome-wide analysis;genomic data;Genomic Instability;genomic locus;Genomics;Heterochromatin;Hi-C;Higher Order Chromatin Structure;Human;human disease;Human Genome;Hybrids;Hydrophobicity;Hypertrophy;Image;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;insight;Intercistronic Region;Introns;Knowledge;Length;Link;Maps;Mediating;mortality;Mutation;Neurons;novel therapeutics;Nuclear;Onset of illness;Pathogenicity;Pathologic;Pathology;Patients;Pattern;Peptides;Peripheral;Physiological;Population;Positioning Attribute;prototype;Radial;Reporting;Repression;Resolution;RNA;Short Tandem Repeat;single cell ATAC-seq;single molecule;Somatic Cell;stem;Technology;Testing;Tissues;Trinucleotide Repeat Expansion;Variant;Work

PROJECT_TITLE: Single-cell dissection of chromatin architecture mechanisms connecting pathologic instability and transcriptional silencing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(70)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: LUNDBERG, EMMA  (contact)

PROJECT_TERMS: Acceleration;Affinity;Antibodies;Atlas of Cancer Mortality in the United States;Atlases;Biological Markers;Biology;Breast;Cancer Biology;cancer cell;cancer imaging;cancer therapy;cancer type;candidate marker;Catalogs;Cell Line;Cell model;Cells;Chromosome Mapping;Clinical;Clinical Cancer Center;Clinical Data;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complex;Coupled;Coupling;CRISPR interference;crosslink;Cryoelectron Microscopy;Data;Development;DNA Sequence Alteration;Drug Combinations;Drug usage;ERBB3 gene;Exhibits;experimental study;functional genomics;Genes;Genetic Predisposition to Disease;Genetic study;genomic data;Head and Neck Squamous Cell Carcinoma;Head and neck structure;high throughput screening;Human;Image;In Vitro;in vivo;in vivo imaging;innovation;insight;Malignant Neoplasms;Maps;Mass Spectrum Analysis;metaplastic cell transformation;Modeling;Molecular;Molecular Biology;mouse model;mutant;Mutate;Mutation;new technology;novel;Oncogenic;Pathway interactions;patient derived xenograft model;patient population;Pattern;Pharmaceutical Preparations;PIK3CG gene;Precision therapeutics;Prediction of Response to Therapy;protein complex;protein protein interaction;Protein-Protein Interaction Map;Proteins;Proteomics;Recurrence;Regulation;Research;Research Personnel;Resolution;Resources;Sampling;Small Interfering RNA;Spatial Distribution;Squamous Cell Lung Carcinoma;structural biology;Structure;targeted cancer therapy;Technology;Testing;Therapeutic;therapeutic target;Tissues;TP53 gene;treatment response;tumor;tumor heterogeneity;tumor progression;tumorigenesis;Validation;Work

PROJECT_TITLE: Project 1: Systematic Physical and Spatial Mapping of Cancer Driver Networks


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Human Genome;Pediatric;Prevention;Rare Diseases

PHR: Project 2: Project Narrative Project 2 will define the cancer risk to relatives in LMS families through large population databases and apply whole genome sequencing (WGS) to a very large LMS cohort to definitively map both common and rare germline variant associations with LMS, focusing on TP53 and other DNA damage response (DDR) genotypes. We will further characterize LMS risk in Li-Fraumeni Syndrome (LFS) by analyzing genotypic and phenotypic data from large LFS database. This work will set the foundations for genetic testing guidelines and risk management for families affected by LMS.

PI_NAMEs: THOMAS, DAVID  (contact)

PROJECT_TERMS: Adult;Affect;Attitude;BRCA2 gene;Breast;Cancer Biology;cancer diagnosis;cancer genetics;cancer predisposition;cancer risk;case control;Categories;Characteristics;Chromosome Mapping;Clinical;Clinical Trials;clinically actionable;cohort;Collection;Communication;Companions;Confusion;Data;Databases;Development;Diagnosis;Disease;disease-causing mutation;DNA;DNA Binding Domain;DNA Damage;DNA Repair;Elements;epidemiology study;ERCC2 gene;Family;Family Cancer History;family management;Family member;Foundations;Future;General Population;Genes;Genetic;genetic epidemiology;genetic information;Genetic Predisposition to Disease;Genetic Risk;genetic risk assessment;genetic risk factor;genetic testing;genome sequencing;Genomics;Genotype;Germ Lines;Germ-Line Mutation;Goals;Guidelines;Hereditary Malignant Neoplasm;Hereditary Neoplastic Syndromes;Histologic;improved;Individual;Inherited;International;International Agency for Research on Cancer;kindred;leiomyosarcoma;Li-Fraumeni Syndrome;Lifting;Malignant Neoplasms;Maps;Medical;Medical Genetics;Mutate;Mutation;novel;novel strategies;Ovarian;Pancreas;Pathogenicity;Pathway interactions;Patients;Pattern;Phenotype;phenotypic data;Play;Population;population based;Population Database;Predisposition;Prevalence;proband;Prostate;psychosocial;Psychosocial Assessment and Care;psychosocial outcome;rare variant;RB1 gene;Recording of previous events;reference genome;Registries;Relative Risks;Reporting;Resources;response;Retinoblastoma;Risk;Risk Assessment;Risk Estimate;Risk Management;Role;Sarcoma;Scientist;Screening for cancer;Second Primary Neoplasms;Series;Site;Soft tissue sarcoma;Statistical Methods;Surveys;Susceptibility Gene;Syndrome;Testing;testing uptake;Therapeutic;TP53 gene;tumor;tumorigenesis;Utah;Variant;whole genome;Work

PROJECT_TITLE: PROJECT 2:   Understanding the role of TP53 in LMS development


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed work is relevant to public health given the high rates of COVID-19 in correctional systems – which disproportionately incarcerate Black, Latinx, and poor individuals thereby affecting the families and communities to which people return after release. The project is relevant to NIMHD's mission-driven strategic goals to stimulate research to improve minority health and close the gaps in health disparities. By building strategic partnerships with individuals with a history of incarceration, correctional officers and community and correctional policymakers, we will identify and test the effectiveness of various interventions specific to correctional systems that improve COVID-19 and influenza vaccine uptake, especially among minority communities.

PI_NAMEs: OMER, SAAD B.;PUGLISI, LISA BALZANO (contact);SIMPSON-BEY, RONALD

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: acceptability and feasibility;Address;Advocate;Affect;Black Populations;Black race;booster vaccine;Cells;Cluster randomized trial;Color;Communities;community academic partnership;community based participatory research;community engaged research;community engagement;compare effectiveness;correctional system;COVID-19;COVID-19 impact;COVID-19 mortality;COVID-19 pandemic;COVID-19 vaccine;Data;Disease Outbreaks;disparity reduction;distrust;Dose;effective intervention;Effectiveness of Interventions;effectiveness study;effectiveness testing;evidence base;Family;General Population;Goals;Guidelines;health care model;health disparity;Health Personnel;Healthcare;Imprisonment;improve minority health;improved;Individual;Infection;infection rate;Influenza;Influenza vaccination;influenza virus vaccine;Information Dissemination;innovation;Intervention;Interview;Jail;Justice;Knowledge;Latinx;Latinx population;Legal system;Link;marginalized population;Medical;minority communities;Minority Groups;Mission;Morbidity - disease rate;multidisciplinary;National Institute on Minority Health and Health Disparities;Patients;Pennsylvania;Persons;Phase;Policy Maker;Population;prison population;Prisons;Provider;Public Health;RADx Underserved Populations;Recording of previous events;Reporting;Research;SARS-CoV-2 infection;Series;social norm;Social Policies;Structure;System;Testing;trial design;Trust;United States;United States National Institutes of Health;Update;Vaccination;vaccine acceptance;vaccine delivery;Vaccines;Variant;Virus;Work

PROJECT_TITLE: Addressing Vaccine AcceptaNce in Carceral Settings through Community Engagement (ADVANCE)

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Rare Diseases;Women's Health Research

PI_NAMEs: FRALEY, STEPHANIE IRENE (contact)

PROJECT_TERMS: arm;Biological Assay;Breast Cancer Patient;cancer cell;cancer subtypes;cell behavior;Cell Line;Cell Proliferation;Cells;Cessation of life;Chromosome Mapping;Clinical;clinical translation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;combinatorial;CRISPR screen;CRISPR/Cas technology;Data;Development;Disease;Drug Interactions;Drug Targeting;Engineering;Event;experimental study;explainable artificial intelligence;Face;Gene Deletion;Gene Targeting;Genes;Genetic;Genetic Epistasis;Genetic Screening;Genomics;Head and Neck Squamous Cell Carcinoma;in vivo;individualized medicine;Intervention;Knock-out;Libraries;Link;Logic;Mali;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Measurement;Measures;member;Methodology;Methods;Molecular;Mutate;new technology;novel therapeutic intervention;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pharmacogenetics;Phenotype;PIK3CG gene;precision medicine;precision oncology;Predisposition;prospective test;Protein-Protein Interaction Map;Proteins;Reporter;Reporting;Research Personnel;Resistance;response;reverse genetics;Signal Transduction;spatiotemporal;Squamous cell carcinoma;Squamous Cell Lung Carcinoma;synthetic lethal interaction;System;Technology;Testing;therapeutic target;Time;TP53 gene;Treatment Efficacy;tumor;tumor progression;tumorigenesis

PROJECT_TITLE: Project 2: Functional Genetic Networks for Systems-Guided Precision Medicine


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Orphan Drug;Patient Safety;Precision Medicine;Prevention;Rare Diseases

PHR: Project 3: Project Narrative Leiomyosarcoma (LMS) is an aggressive soft tissue sarcoma that remains difficult to cure even with intensive chemotherapy and surgery. In this study, blood samples from patients with metastatic LMS will be used to profile circulating tumor DNA to identify genomic features that are associated with a high-risk of treatment failure. Results from this study will enable the development of new risk-based and personalized treatment strategies for patients with LMS.

PI_NAMEs: CROMPTON, BRIAN  (contact)

PROJECT_TERMS: Adult;Anesthesia procedures;Biological Markers;Biology;Biopsy;Biopsy Specimen;Blood;Blood specimen;burden of illness;Cancer Biology;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;clinical care;clinical decision-making;Clinical Research;Clinical Trials;Clonal Evolution;cohort;Collection;Consensus;Correlation Studies;Cytotoxic Chemotherapy;Data;deep sequencing;design;Detection;Development;Diagnosis;Diagnostic;Disease;disease natural history;Disease Progression;Disease Resistance;disorder control;docetaxel;Doxorubicin;Evolution;experience;experimental study;Future;gemcitabine;Gene Mutation;Genetic;genomic profiles;Genomics;Heterogeneity;high risk;Image;improved;improved outcome;In Vitro;in vivo;insight;leiomyosarcoma;Lesion;liquid biopsy;Malignant Neoplasms;Metastatic Leiomyosarcoma;Modality;Modeling;Mutation;Newly Diagnosed;next generation sequencing;novel;novel strategies;novel therapeutic intervention;Oncologist;Operative Surgical Procedures;Outcome;participant enrollment;patient derived xenograft model;Patient Selection;patient subsets;Patient-Focused Outcomes;Patients;Pattern;personalized medicine;Pilot Projects;Plasma;prevent;Prognosis;prognostic;Prognostic Factor;Prognostic Marker;Progression-Free Survivals;prospective;Proxy;radiation risk;radiological imaging;Radiology Specialty;Recurrence;Regimen;Relapse;Research;Research Personnel;Resistance;resistance mechanism;response;Risk;Safety;Sampling;side effect;single cell sequencing;Single Nucleotide Polymorphism;Smooth Muscle;Soft tissue sarcoma;Solid;Systemic Therapy;Technology;Testing;therapy resistant;Time;Toxic effect;Treatment Failure;Treatment Futility;treatment response;treatment strategy;tumor;tumor DNA;tumor heterogeneity;Unresectable;Validation;Variant

PROJECT_TITLE: PROJECT 3:  Applying Liquid Biopsy Technologies to Detect Clinical Response and Mechanisms of Resistance in the Treatment of LMS


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Mental Health;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Public Health Relevance: Binge drinking is very common in adolescents and continued alcohol abuse by this population can lead to the development of psychiatric disorders including alcohol use disorder (AUD) in adulthood. The proposed studies will continue to elucidate the molecular mechanisms of adolescent intermittent ethanol (AIE) induced behavioral phenotypes in adulthood that are under investigation by the NADIA consortium. These studies will lead to the development of epigenetic-based therapies for adolescent binge drinking induced adult psychopathology.

PI_NAMEs: PANDEY, SUBHASH C. (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Acetylation;Adolescence;Adolescent;adolescent alcohol exposure;adolescent binge drinking;Adult;Alcohol abuse;alcohol use disorder;Alcoholism;Alcohols;Amygdaloid structure;Anxiety;Area;ATAC-seq;Back;basal forebrain;Behavioral;behavioral phenotyping;binge drinking;Bioinformatics;Biological Assay;Brain;Brain region;Candidate Disease Gene;candidate identification;Chimeric Proteins;Chromatin;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive deficits;CRISPR/Cas technology;Data;Development;DNA Methylation;DNMT3B gene;Enhancers;EP300 gene;Epigenetic Process;epigenome;epigenomics;Ethanol;Funding;Gene Expression;gene network;Genes;Genome;genomic locus;Goals;Hippocampus;Histone Acetylation;histone modification;Histones;Hypothalamic structure;Individual;Intercistronic Region;Investigation;KDM1A gene;Life;Link;Location;Mediating;Mental Depression;Mental disorders;Messenger RNA;Methylation;Modification;Molecular;molecular phenotype;Neurobiology;Neurons;novel;novel therapeutic intervention;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Population;Prefrontal Cortex;promoter;Psychopathology;public health relevance;Rattus;Research;Research Project Grants;Resources;Risk Factors;Technology;Testing;Time;tool;transcriptomics;treatment strategy;underage drinking;whole genome;Work

PROJECT_TITLE: 1/1 NADIA U24 Epigenetic/Molecular Scientific Resource Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Genetics;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: IDEKER, TREY  (contact)

PROJECT_TERMS: Affect;Affinity Chromatography;Architecture;Biological;Biological Assay;Biological Markers;Breast;cancer cell;cancer genome;Cancer Model;cancer therapy;cancer type;Cell model;Cells;Cellular Structures;Clinical;Clinical Data;clinical translation;clinically relevant;combinatorial;Complex;computer framework;confocal imaging;crosslink;Cryoelectron Microscopy;Data;Data Analyses;data modeling;Data Set;deep learning;design;Development;DNA Sequence Alteration;drug response prediction;ERBB3 gene;Evaluation;Expert Systems;FRAP1 gene;Funding;Generations;Genes;Genetic;Head and Neck Cancer;Head and Neck Neoplasms;Head and neck structure;Heterogeneity;Human;Image;Immunofluorescence Immunologic;improved;Knowledge;Learning;Lung;Lung Neoplasms;machine learning model;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Medicine;Methodology;Methods;Modeling;Molecular;multimodality;Mutate;Mutation;neoplastic cell;Organelles;Pathway interactions;patient derived xenograft model;Patients;Phenotype;PIK3CA gene;Population;precision medicine;predictive modeling;protein complex;protein distribution;Protein Dynamics;Proteins;Research Personnel;Resolution;response;Risk;Sampling;Somatic Mutation;structural biology;Structural Models;Structure;System;Techniques;three-dimensional modeling;Training;transfer learning;Translations;Treatment outcome;tumor;Work;Xenograft procedure

PROJECT_TITLE: Project 3: From Networks and Structures to Hierarchical Whole Cell Models of Cancer


PHR: Core B – Biospecimen Core - Narrative: Leiomyosarcoma (LMS) is a rare and aggressive soft tissue sarcoma that can be difficult to diagnose and treat. The Biospecimen Core will support the LMS SPORE investigators by conducting expert pathology review and facilitating the collection, specialized processing, storage, and distribution of high quality biospecimens. Any residual biospecimens will be banked and made available following review to qualified investigators who have innovative ideas.

PI_NAMEs: HORNICK, JASON  (contact)

PROJECT_TERMS: accurate diagnosis;Address;Adult;biobank;Biological Assay;Biological Specimen Banks;Blood;bone;Cancer Biology;Cells;Child;Clinical Research;Collaborations;Collection;Data;Databases;Dermis;Diagnosis;diagnostic accuracy;digital imaging;Doctor of Philosophy;Ensure;experience;Future;Gastrointestinal tract structure;Genetic;Genomics;Guidelines;Heart;Histology;Hospitals;Human;imaging system;Immunohistochemistry;improved;innovation;Institution;Leadership;leiomyosarcoma;Limb structure;Malignant Neoplasms;medical schools;Nature;Neoplasm Metastasis;novel strategies;Nucleic Acids;Organ;participant enrollment;Pathologist;Pathology;Patients;Pediatric Hospitals;Physician Executives;Population;Procedures;professor;Prognosis;Protocols documentation;Qualifying;Quality Control;rare cancer;Research;Research Institute;Research Personnel;Residual state;Resolution;Resources;Retroperitoneal Space;Sampling;Sarcoma;Services;Slide;Smooth Muscle;Soft tissue sarcoma;Stains;Standardization;success;Surgical Pathology;technological innovation;Tissue Microarray;Tissues;translational goal;Translational Research;tumor;Uterus;Veins;Woman;Work

PROJECT_TITLE: Core B- Biospecimen Core


PI_NAMEs: BACHELDER, ROBIN ELIZABETH (contact)

PROJECT_TERMS: Adult;anti-cancer research;Area;bioinformatics tool;Biological Sciences;cancer cell;Cancer Patient;Child;clinical translation;Communities;Data Set;Dedications;Education;Educational workshop;Engineering;Event;Faculty;Family;Festival;forgetting;General Population;Goals;graduate student;Institution;Leadership;Learning;Link;Malignant Neoplasms;Maps;Medicine;member;next generation;outreach;Patients;Persons;Play;Postdoctoral Fellow;programs;Public Opinion;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Role;Science;Scientist;Site;Societies;symposium;Systems Biology;Taste Perception;Technical Expertise;Techniques;Training;Training Activity;web portal;Work

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Lung;Lung Cancer;Rare Diseases

PROJECT_TERMS: Affinity;Affinity Chromatography;Atlas of Cancer Mortality in the United States;Bioinformatics;Biological Assay;Biological Sciences;Breast;cancer cell;Cancer cell line;Cancer Model;cancer type;Cell Line;Cell model;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combinatorial;comparative;Complex;Computational Biology;Core Facility;Coupled;CRISPR/Cas technology;crosslink;Cryoelectron Microscopy;Data;Dependence;Disease;Education;experimental study;fitness;functional genomics;gain of function;Generations;Genes;Genetic;Genetic Screening;Genomic medicine;Genomics;Goals;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Infrastructure;insight;interest;Knock-in;Knock-out;Lead;loss of function;Mali;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measures;Mentors;migration;Modeling;Molecular;mutant;Mutate;Mutation;network models;novel;Outcome;outreach;Pathogenesis;Pathology;Pathway Analysis;Pathway interactions;patient stratification;Phenotype;Physiological;PIK3CG gene;Point Mutation;Protein Binding Domain;protein complex;Protein Complex Subunit;protein expression;protein function;protein protein interaction;protein purification;protein structure;Protein-Protein Interaction Map;Proteins;Proteomics;Recurrence;Reproducibility;Research Personnel;Research Project Grants;Research Support;reverse genetics;software infrastructure;Specificity;Squamous Cell Lung Carcinoma;stoichiometry;Structure;Systems Biology;targeted cancer therapy;targeted treatment;Technical Expertise;Technology;Tertiary Protein Structure;TP53 gene;Training;tumor progression;tumorigenesis;Variant

PROJECT_TITLE: Core 1: Functional Genomics and Proteomics


PI_NAMEs: BALADANDAYUTHAPANI, VEERABHADRAN  (contact)

PROJECT_TERMS: adverse event monitoring;Archives;Area;Bioinformatics;Biological Assay;Biometry;Cancer Biology;Cancer cell line;career development;Case Report Form;Clinical Data;Clinical Research;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Cohort Studies;Collaborations;Collection;Communication;computational platform;Data;data access;Data Analyses;Data Collection;data management;data mining;data quality;Data Set;Data Sources;data standards;Databases;Dedications;Dependence;Development;Diagnosis;DNA Damage;drug sensitivity;Encyclopedias;Ensure;Epidemiology;epidemiology study;experience;Experimental Designs;experimental study;Generations;Genetic;genomic data;Genomics;health data;Human Resources;improved;Information Dissemination;Infrastructure;Institution;Investigational Therapies;Knowledge;leiomyosarcoma;Li-Fraumeni Syndrome;Link;Location;Malignant Neoplasms;Manuscripts;Maps;member;Methodological Studies;Methodology;Michigan;Molecular;multidisciplinary;Nature;novel strategies;Patients;Policies;Population Database;programs;Prospective cohort;public repository;Quality Control;radiomics;Registries;Reproducibility;Research;Research Activity;Research Design;Research Personnel;research study;Resources;response;sample collection;Sampling;single-cell RNA sequencing;Source;Time;transcriptome sequencing;translational study;trial design;Universities;Utah;Work

PROJECT_TITLE: Core C- Data Analysis Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: DALLAS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Pregnant women with chronic hypertension are at an increased risk for placental-mediated disease, as 1 in 3 pregnant women with chronic hypertension deliver preterm from complications of superimposed preeclampsia or fetal growth restriction. This project will address the unmet clinical need to characterize placental dysfunction throughout pregnancy, focusing specifically on differences in functional magnetic resonance imaging metrics of perfusion, diffusion, and oxygenation and radiomics texture features between normal pregnant women and pregnant women with chronic hypertension. Furthermore, execution of automated segmentation through deep learning will be performed to standardize and improve the efficiency of post- processing.

PI_NAMEs: HERRERA, CHRISTINA LYNN (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Address;Affect;Area;arterial spin labeling;Arteries;automated segmentation;Award;Basic Science;blood oxygen level dependent;Blood Vessels;career;Characteristics;Chronic;Clinical;clinical investigation;Clinical Investigator;clinical predictors;Clinical Research;Clinical Sciences;cohort;contrast imaging;Data;deep learning;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Doppler Ultrasound;Early identification;faculty mentor;Fetal Growth Retardation;Fetal health;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Grant;Growth;Heterogeneity;Human;Hypertension;hypertensive;hypoperfusion;Image;imaging modality;imaging Segmentation;improved;in vivo;insight;Interdisciplinary Study;interest;Intervention;K-Series Research Career Programs;Knowledge;Libraries;Magnetic Resonance;Magnetic Resonance Imaging;Manuals;Maps;Maternal Health;Measurement;Measures;Mediating;Mentors;Motion;non-invasive imaging;novel;Outcome;Pathologic;Pathology;Pattern;Peer Review;Perfusion;Placenta;Placenta Diseases;Placentation;Populations at Risk;Pre-Eclampsia;predictive marker;predictive modeling;Pregnancy;pregnant;Pregnant Women;prenatal exposure;Process;prospective;protein biomarkers;Publications;radiomics;Reproducibility;Reproducibility of Results;Research;Research Personnel;Resistance;Risk;Role;Second Pregnancy Trimester;skills;Spiral Artery of the Endometrium;Standardization;T2 weighted imaging;Technical Expertise;Techniques;Technology;Testing;Texture;Translational Research;ultrasound;Uterus;Woman;Work

PROJECT_TITLE: Functional and Radiomic Magnetic Resonance Profiling in Normal and Hypertensive Placentas

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


NIH_SPENDING_CATS: Bioengineering;Cancer;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Biological;cancer cell;Cell model;Cells;Code;Computer software;Custom;Data;Data Analyses;data dissemination;data exchange;data resource;Deposition;Development;digital object identifier;Ecosystem;Elements;Environment;Generations;Genetic;Infrastructure;infrastructure development;Lead;Libraries;Link;Maps;network models;Ontology;Pathway Analysis;protein protein interaction;protein structure;Proteomics;public repository;Publications;Publishing;Pythons;repository;Research;Research Personnel;Resources;Scientist;Services;Software Framework;software infrastructure;Software Tools;tool;Visualization;web app;web interface;web portal;web services;web site;Work

PROJECT_TITLE: Core 2: Software Infrastructure for Network Models and Cell Maps


PI_NAMEs: ROBINSON, STEVEN  (contact)

PROJECT_TERMS: Award;Biology;Black race;Cancer Biology;Cancer Center;career;career development;Clinic;Clinical;Clinical Trials;Collaborations;Communities;Complement;Complex;Data;Department of Defense;design;Development;Diagnosis;Disease;Doxorubicin;Drug resistance;Dystrophin;Early Therapeutic-Clinical Trials Network;Ensure;Ewings sarcoma;experience;Faculty;Female;Foundations;Funding;Genetic;Genomics;Goals;Grant;Hemangioendothelioma;Hispanic;Immunooncology;improved;innovation;Institution;interest;Investigation;Jamaica;Jamaican;Latino;Lead;Leadership;leiomyosarcoma;Local Therapy;man;Medical Faculty;medical schools;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Michigan;mid-career faculty;Minority;minority investigator;molecular diagnostics;Molecular Target;Neoadjuvant Therapy;novel strategies;Osteosarcoma;participant enrollment;Pathology;Patients;Pharmaceutical Preparations;Pilot Projects;Positioning Attribute;Principal Investigator;professor;Program Development;Program Research Project Grants;programs;Qualifying;Radiation therapy;Recommendation;recruit;Regulation;Research;Research Personnel;Sarcoma;Science;Scientist;synovial sarcoma;Therapeutic;translational goal;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Woman;Wood material

PROJECT_TITLE: Developmental Research Program


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Radiation Oncology;Rare Diseases

PI_NAMEs: DEMICCO, ELIZABETH  (contact)

PROJECT_TERMS: Achievement;Anatomy;Area;Basic Science;Behavior;Biological Markers;Biology;Biomedical Engineering;Biometry;Cancer Biology;cancer type;care coordination;career;career development;Caring;Characteristics;Clinical;Clinical Investigator;Committee Members;Dana-Farber Cancer Institute;design;Development;Diagnosis;Discipline;Disease;disease model;Ensure;Equilibrium;experience;Faculty;Foundations;Funding;Funding Mechanisms;Genetic;Genetic Predisposition to Disease;Genomics;Genotype;Goals;human capital;improved;In Vitro;in vitro Model;in vivo Model;Individual;innovation;insight;Institution;integrated care;interdisciplinary approach;Interdisciplinary Study;Investigational Therapies;Laboratories;Leadership;Learning;leiomyosarcoma;Life Expectancy;Medical;Medical Oncologist;Medical Oncology;Medicine;member;Mentors;Mentorship;Minority;Molecular;multidisciplinary;Nature;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Pathologist;Pathology;Patients;Pediatric Oncology;Phenotype;pressure;Productivity;programs;Qualifying;Quality of life;Radiation;Radiation Oncologist;Radiation Oncology;Records;recruit;Rejuvenation;Research;Research Personnel;Research Support;Sarcoma;Science;Scientist;soft tissue;Solid;Source;Specialist;success;Surgeon;Surgical Oncology;Talents;Time;Training;translational cancer research;Translational Research;translational scientist;translational study;tumor;Universities;Uterine Leiomyosarcoma;Validation;Woman

PROJECT_TITLE: Career Enhancement Program


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: MISCELLANEOUS

PHR: Project Narrative Transcriptional programs control the development and functionality of specialized cell types and states. We propose to develop transformative computational frameworks by integrating single-cell multi-omics datasets for systematically determining transcription factors driving cellular identity to study a diverse set of developmental and disease processes.

PI_NAMEs: OSMANBEYOGLU, HATICE ULKU (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Automobile Driving;Cell Surface Receptors;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromatin;Communities;computer framework;Computer software;computerized tools;Computing Methodologies;Data;Data Set;deep learning;Development;Disease;explainable machine learning;Genes;Genetic Transcription;Goals;Heterogeneity;Human;Knowledge;Link;Measurement;Measures;Membrane Proteins;Methods;Modality;Modeling;Multiomic Data;multiple omics;multitask;preservation;Process;programs;Proteins;Proteomics;Research;response;RNA;Sampling;Signal Transduction;Technology;Tissues;transcription factor;transcriptomics

PROJECT_TITLE: Computational methods for delineating cell context-specific regulatory programs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Complementary and Integrative Health;Depression;Dietary Supplements;HIV/AIDS;Heart Disease;Infectious Diseases;Mental Health;Mental Illness;Microbiome;Nutrition;Precision Medicine;Prevention;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE People with HIV-infection and concurrent hazardous drinking, smoking, and depressive symptoms (i.e., alcohol-associated syndemic) experience higher risk of cardiovascular disease compared to those without these behavioral health conditions. The gastrointestinal (GI) microbiome is a strong candidate mechanistic pathway for the syndemic-related excess CVD risk, through GI dysbiosis, microbial translocation (MT), and systemic inflammation. This proposal aims to test the hypotheses that the alcohol-associated syndemic is associated with GI dysbiosis and subsequent CVD risk and that targeted supplementation may restore GI microbiome homeostasis and reduce inflammation; aligning with NIAAA’s objectives to prevent and treat HIV- associated comorbidities and invest in HIV/alcohol translational research that addresses health and behavioral issues clearly linked with HIV in the context of HIV, other substance use/addiction and mental health disorders.

PI_NAMEs: CHICHETTO, NATALIE E (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;addiction;Address;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol exposure;alcohol use disorder;Alcohols;Attenuated;Automobile Driving;Award;Back;Bacteria;Bacteroidetes;Behavior Therapy;Behavioral;behavioral health;Biodiversity;Biological Markers;Blood Circulation;Butyrates;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular disorder therapy;career development;clinical investigation;Clinical Research;Clinical Trials;comorbidity;Competence;Data;Data Collection;depressive symptoms;Development;Development Plans;Disease;drinking;dysbiosis;early-career faculty;Endotoxins;Engraftment;Evaluation;experience;Feasibility Studies;Firmicutes;follow-up;Funding;gastrointestinal;Growth;gut microbiome;hazardous drinking;Health;Health Benefit;Heavy Drinking;high risk;HIV;HIV Infections;Homeostasis;Human;Immunology;Inflammation;Inflammation Mediators;Inflammatory;Infrastructure;Investments;Leadership;Link;member;men;Mental Depression;Mental disorders;Mentored Research Scientist Development Award;Mentors;microbial;microbiome;microbiome composition;microbiome research;microorganism;mortality;mortality risk;Mus;National Institute on Alcohol Abuse and Alcoholism;Nutrient;Outcome;Pathway interactions;Patient Self-Report;Patients;Permeability;Persons;Phenotype;pill;poor health outcome;Population;post intervention;prebiotics;prevent;Probiotics;Proteobacteria;Reporting;Research;Research Personnel;responsible research conduct;Risk;Risk Reduction;Serum;skills;Smoking;Social Work;substance use;Supplementation;syndemic;systemic inflammatory response;targeted treatment;Teacher Professional Development;Tennessee;Testing;Therapeutic;Tight Junctions;timeline;Training;Translational Research;treatment effect;Visit;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Alcohol-Associated Syndemic and Microbiome Evaluation and Targeted Treatment in Persons Living with HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Hearing Loss;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Our project aligns with the National Alzheimer’s Project Act to “prevent, halt, or reverse Alzheimer’s disease.” It is responsive to PAR-18-877 to “develop and implement early stage (Phase I or II) clinical trials of promising…non-pharmacologic interventions” including “in individuals with…presymptomatic…stages of disease.” Because age-related hearing loss is highly prevalent, uncommonly treated, and recognized as a major risk factor for Alzheimer’s disease and related dementias, this project is of high public health significance and potential high impact.

PI_NAMEs: GOLUB, JUSTIN SCOTT (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Adherence;age related;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;amnestic mild cognitive impairment;Amyloid;arm;Auditory;Auditory area;Behavioral;Brain;Chronic;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive load;cognitive performance;cognitive testing;Comparison arm;cooperative study;Data;Dementia;Development;Devices;Diagnosis;diffusion weighted;digital measure;Disease;efficacy testing;Elderly;Functional Magnetic Resonance Imaging;Genotype;Goals;Health education;Hearing;Hearing Aids;hearing impairment;Hour;human old age (65+);Impaired cognition;improved;Individual;interest;Intervention;intervention effect;Investigation;Knowledge;late life;Link;Magnetic Resonance Imaging;Measures;Mediating;mild cognitive impairment;multidisciplinary;Neuropsychology;Nonpharmacologic Therapy;older adult;Older Population;Outcome;Participant;Pathologic;Pathway interactions;Performance;Phase;Phase I Clinical Trials;Plasma;preclinical study;Presbycusis;prevent;Prevention;programs;Public Health;Pure-Tone Audiometry;Randomized, Controlled Trials;Reporting;response;Rest;Risk;Risk Factors;sex;Site;social;Social Change;social engagement;Target Populations;Testing;Time;treatment arm;Visual

PROJECT_TITLE: Early Age-Related Hearing Loss Investigation (EARHLI): A Randomized Controlled Trial to Assess Mechanisms Linking Early Age-Related Hearing Loss and Alzheimer's Disease and Related Dementias


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences;Pediatric

ORG_DEPT: NEUROSCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative In order to significantly advance mental health and prevent or treat neurodevelopmental disorders it is important that we understand how brain functions develop. Learning and memory processes significantly contribute to most complex brain functions, yet the biological mechanisms underlying learning and memory during early development are largely unknown. This project proposes to identify brain regions, network of activated cells and profiles of molecular changes induced by infantile learning, hence providing an unprecedented amount of novel information regarding the biological mechanisms of infantile learning and memory.

PI_NAMEs: ALBERINI, CRISTINA M (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Adult;Age;Animals;base;Behavior;Behavioral;behavioral study;Biological;Biological Process;Brain;Brain region;Cell Separation;cell type;Cells;Chronic;Cognition Disorders;Cognitive;cognitive ability;Complex;critical developmental period;critical period;designer receptors exclusively activated by designer drugs;Development;Dorsal;early experience;Episodic memory;excitatory neuron;experience;experimental study;Female;Functional disorder;Funding;Gene Expression;genetic technology;Genetic Transcription;Genetically Engineered Mouse;Hippocampus;Hour;Imaging technology;Immediate-Early Genes;Immunohistochemistry;In Situ;Individual;infancy;Infant;infant animal;inhibitory neuron;interest;Investigation;Knowledge;Learning;Life;Life Experience;Link;male;Maps;Medial;medial temporal lobe;member;Memory;memory process;memory recall;Mental Health;Messenger RNA;Molecular;molecular imaging;Molecular Profiling;Mus;Neurodevelopmental Disability;Neurodevelopmental Disorder;Neurons;novel;operation;Pathway interactions;Personality;Prefrontal Cortex;prevent;Process;Psychopathology;Rattus;Recovery;response;Ribosomes;RiboTag;Rodent Model;Role;sensory system;sex;Shapes;social;Source;spatial memory;Stains;Stimulus;Stress;System;Technology;Testing;Time;trait;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translating;translatome;Trauma;virtual;Visual;Work

PROJECT_TITLE: Molecular mechanisms of infantile learning and memory

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: NORMAN

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: Skin color is genetically derived traits that is highly variable between human subpopulations and is determined by the quantity, type and distribution of melanin pigment. Variable melanin production by skin pigment cells not only drives skin color variation but also contributes to differential disease susceptibility among humans. This proposal seeks to understand the epigenetic and transcriptional mechanisms that govern variable melanin production resulting in human pigmentation diversity and has implications for human evolution, health and disease.

PI_NAMEs: BAJPAI, VIVEK KUMAR (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Affect;Anatomy;Automobile Driving;Biological Assay;Candidate Disease Gene;Cells;Chromosome Mapping;Code;Color;Control Locus;CRISPR screen;Darkness;differential expression;Disease;Disease susceptibility;DNA;Enhancers;Epigenetic Process;epigenomic profiling;Evolution;experimental study;Gene Dosage;Gene Expression;Genes;Genetic;Genetic Screening;Genetic study;Genetic Transcription;Genome;Genome engineering;genome wide association study;genome-wide;Genotype;Goals;Hair Color;Health;Human;Human Development;human population study;In Vitro;insight;Instruction;Knowledge;Light;Location;Maps;Measurement;Melanins;melanocyte;Melanogenesis;Methods;Modeling;Molecular;mouse model;Mus;Natural Selections;Normal Range;novel;Phenotype;Pigmentation physiologic function;Pigments;Play;pluripotent stem cell differentiation;Postdoctoral Fellow;Production;programs;Reporter;Role;skin color;skin disorder;Skin Pigmentation;trait;transcription factor;Transgenic Mice;Validation;Variant;Work

PROJECT_TITLE: Epigenetic and transcriptional mechanisms driving human pigmentation diversity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Cardiovascular disease remains the leading cause of morbidity and mortality in the United States, and cardio- metabolic conditions are the emerging threat with the epidemic of obesity and metabolic syndrome. The key objective of this training program is to prepare the next generation of physician-scientists and scientists to apply principles in cardiovascular research to understand the underlying mechanisms and develop strategies to prevent or treat these diseases, with a focus on quality, access and affordability of health care. This program seeks MDs, MD-PhDs or PhD post-doctoral trainees to train with established mentors pursuing high impact cutting edge research, towards the goal of becoming independent physician-scientists and researchers.

PI_NAMEs: DIWAN, ABHINAV  (contact);JOYNT MADDOX, KAREN ELLEN;SAH, RAJAN

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Cardiovascular system;Research Training;Training Programs

PROJECT_TITLE: Principles in Cardiovascular Research Training Program

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

PHR: The Public Health Relevance: Adolescent binge drinking is one of the major risk factors for development of substance and alcohol-use disorders later in life. This proposal will enhance our understanding of neuronal epigenetic mechanisms associated with the development of anxiety and alcohol use disorder (AUD) in adulthood after adolescent alcohol exposure. In addition, this research will identify novel epigenetic or molecular targets that can be used to develop future therapeutic agents in treating adult psychopathology after adolescent alcohol exposure.

PROJECT_TERMS: Adolescence;Adolescent;adolescent alcohol exposure;adolescent binge drinking;Adult;Age of Onset;age related;Alcohol consumption;alcohol use disorder;Alcohols;Amygdaloid structure;Anxiety;anxiety-like behavior;ATAC-seq;Attenuated;Autopsy;axon guidance;Azacitidine;Behavioral;Bioinformatics;Brain;Brain-Derived Neurotrophic Factor;Chemicals;Chromatin;Chromatin Structure;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;CREBBP gene;Cytoskeleton;Data;Data Set;Dendritic Spines;Development;DNA;DNA Methylation;DNA Methylation Inhibition;DNA Modification Methylases;DNMT3B gene;drinking;drinking behavior;drug development;Drug Targeting;Enzymes;EP300 gene;Epigenetic Process;epigenetic regulation;epigenome;epigenome editing;epigenomics;Ethanol;Event;EZH2 gene;Female;Funding;Future;Gene Expression;gene network;Genes;genome-wide;genomic locus;HDAC2 gene;Histone Acetylation;histone acetyltransferase;Histone Deacetylase;Histone Deacetylase Inhibitor;histone methylation;Histones;Human;inhibitor;KDM1A gene;Lead;Life;Lysine;male;Mental disorders;Methylation;Modification;Molecular Target;Neurobiology;Neurons;neuropeptide Y;next generation sequencing;novel;Pathway interactions;Pharmacotherapy;preclinical study;problem drinker;Process;Proteins;Psychopathology;public health relevance;Rattus;Regulation;Research;Risk Factors;Role;Site;substance use;Synapses;Testing;Therapeutic Agents;therapy development;Tissue-Specific Gene Expression;transcriptome;transcriptome sequencing;transcriptomics;Translating;translational study;Trichostatin A;underage drinking;whole genome

PROJECT_TITLE: 3/8 NADIA U01 Adolescent Alcohol, Epigenetics and Behavioral Changes in Adulthood


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention

ORG_DEPT: PATHOLOGY

PHR: Klebsiella is a leading cause of healthcare-associated and antibiotic-resistant bacterial infections, and patients who are colonized with Klebsiella in their intestine are at increased risk of infection. The goal of this project is to develop a new tool that can detect and quantify >100 different types (or strains) of Klebsiella simultaneously, both in patient samples and conditions that mimic human colonization and infection. This tool would allow us to identify the traits of Klebsiella that consistently increase the risk of infection and to screen new potential therapeutics against hundreds of Klebsiella strains simultaneously.

PI_NAMEs: BACHMAN, MICHAEL ABBOTT (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;Admission activity;Affect;Alleles;Animal Model;Archives;Bacterial Antibiotic Resistance;Bacterial Infections;Bar Codes;biomarker identification;Blood Circulation;capsule;case control;Case/Control Studies;Clinical;cohort;comparative genomics;Complex;data integration;deep sequencing;Detection;Dideoxy Chain Termination DNA Sequencing;efficacy evaluation;experimental study;Feces;fitness;gastrointestinal;Genes;Genetic Variation;Genome;genomic locus;Goals;gut colonization;Healthcare;healthcare-associated infections;high risk;Hospitals;Human;Infection;Infection prevention;infection risk;Intensive Care;Intensive Care Units;Intervention;Intestines;Klebsiella;Klebsiella Infections;Klebsiella oxytoca;Klebsiella pneumoniae;Liquid substance;Measures;Membrane;Methods;Modeling;mutant;novel;novel therapeutics;Outcome Study;pathogen;Pathogenesis;Pathogenicity;Patient-Focused Outcomes;Patients;Pneumonia;Population;Population Dynamics;Population Heterogeneity;Predisposition;prevent;preventive intervention;Proteins;Rectum;Research;Risk;Sampling;Scheme;Serum;Site;Swab;Techniques;Testing;Therapeutic;Time;tool;trait;Urinary tract infection;Urine

PROJECT_TITLE: Capsular locus deep sequencing to study Klebsiella populations

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

PHR: PROJECT NARRATIVE Cervical cancer is the leading cause of cancer death in women in Zambia, a country in southern Africa, where HIV has heightened the risk of developing and dying from cervical cancer. The HPV vaccination is an evidence-based intervention that, when delivered in adolescence, can prevent most HPV infection—the cause of cervical cancer—and adolescents living with HIV, who are at greater risk, may especially benefit from effective processes to deliver the vaccination to them. Our project builds on a successful stakeholder-engaged, systems thinking approach to design and implement strategies to reduce cervical cancer in low- and middle- income countries—an approach we will use to integrate HPV vaccination services into HIV clinical care, a needed step to reduce global inequities in cervical cancer.

PI_NAMEs: HUNLETH, JEAN MARIE (contact);MITI, SAM ;SILVER, MICHELLE

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: acceptability and feasibility;Address;Adolescence;Adolescent;African;Age;Cancer Burden;Cancer Etiology;cancer prevention;cancer risk;cervical cancer prevention;Cessation of life;Child;Clinic;Clinical;clinical care;clinical infrastructure;Communities;contextual factors;Country;design;Development;Dose;Education;Educational workshop;effectiveness/implementation trial;Elements;Ethnography;evidence base;Evidence based intervention;Exclusion;experience;Exposure to;Feedback;Friends;girls;Health;Health Services;high risk;high risk population;HIV;HIV-infected adolescents;Household;HPV vaccine acceptance;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papillomavirus;Hybrids;implementation design;implementation evaluation;implementation outcomes;implementation research;implementation science;implementation strategy;Inequity;informant;Infrastructure;Institution;Intention;Intervention;Interview;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Methods;Misinformation;Modeling;novel;Orphan;Outcome;peri-urban;Persons;Politics;Population;Prevalence;prevent;Process;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Resources;Risk;routine care;Rural;scale up;Schedule;Schools;Services;Sex Behavior;Site;social stigma;Source;Southern Africa;Strategic Planning;success;supply chain;System;Technical Expertise;Testing;Thinking;tool;Translating;Trust;Vaccination;vaccine access;Vaccines;vulnerable adolescent;Vulnerable Populations;Woman;Women's mortality;Zambia

PROJECT_TITLE: Leveraging HIV infrastructure to implement cervical cancer prevention: A study to integrate HPV vaccination in adolescent HIV clinics in Zambia


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This five-year K01 Mentored Research Scientist Development Award will provide me with the multi-disciplinary mentorship and training to become an independent investigator focused on optimizing the health and well- being of women and girls at high risk of HIV acquisition and transmission. My training proposal comprises (i) expert mentorship and experiential learning with senior HIV and implementation science (IS) researchers; (ii) coursework and workshops in IS theory and methods, qualitative research, and adolescent health and development; and (iii) mentored research to ensure that I am well-positioned to pursue an independent and interdisciplinary research career. The goal of the proposed mentored research project is to develop implementation strategies that strengthen a peer-support HIV treatment model for (AGYW) aged 15-24 living with HIV in Dar es Salaam, Tanzania.

PI_NAMEs: RUCINSKI, KATHERINE B (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: acceptability and feasibility;Active Learning;Address;Adolescence;Adolescent;Adolescent and Young Adult;Adolescent Development;adolescent health;Adolescent Health Services;Adopted;Africa South of the Sahara;age stratification;aged;antiretroviral therapy;Award;career;Caring;Characteristics;Clinic;Communities;Consolidated Framework for Implementation Research;Data;Dedications;Development;Diagnosis;Eastern Africa;Economics;Educational workshop;Effectiveness;Effectiveness of Interventions;effectiveness trial;emerging adult;Emotional;Evidence based intervention;Female Adolescents;Focus Groups;Foundations;Funding;girls;Goals;Government;Health;health care delivery;Health care facility;high risk;HIV;HIV Infections;Hour;Hybrids;implementation research;implementation science;implementation strategy;improved;Incidence;Infection;innovation;Institutional Practice;Interdisciplinary Study;Intervention;Interview;Investments;lens;Link;marginalization;meetings;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Partnership Practice;Patients;Pattern;peer;peer support;Personal Satisfaction;Physiological;Population;Positioning Attribute;Poverty;Prevention;Prevention program;Process;programs;Provider;Psychiatric Social Work;Qualitative Research;Randomized;Recommendation;Research;Research Methodology;Research Personnel;Research Project Grants;Resource-limited setting;response;Risk;scale up;Services;SET Domain;sexual and reproductive health;Sexually Transmitted Diseases;skills;social;Social Behavior;social stigma;South Africa;Southern Africa;Structure;Surveys;System;Tanzania;Teenagers;Testing;theories;therapy adherence;Time;tool;Training;Training Programs;transmission process;uptake;Viral;Woman;young woman

PROJECT_TITLE: Implementation Research to Optimize ART Delivery for Adolescent Girls and Young Women Living with HIV in South Africa

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Disability Research;Hearing Loss;Neurosciences;Orphan Drug;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The goal of this project is to reduce hearing loss in head and neck cancer patients treated with cisplatin chemotherapy. The study is designed to determine if atorvastatin (an FDA-approved drug used to reduce cholesterol) reduces cisplatin-induced hearing loss. If atorvastatin is protective, it could be used to preserve the hearing of patients undergoing platinum-based cancer therapy.

PI_NAMEs: SABA, NABIL F;SCHMITT, NICOLE CHERIE (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Adult;Affect;Aftercare;Age;Animal Model;atorvastatin;Auditory;Cancer Survivor;cancer therapy;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Cholesterol;Cisplatin;cisplatin induced hearing loss;Clinical;Common Terminology Criteria for Adverse Events;Communication;Data;design;Disease-Free Survival;Dose;Dose Limiting;Double-Blind Method;Drug usage;Effectiveness;Equilibrium;Extramural Activities;FDA approved;Follow-Up Studies;Goals;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;Hearing;hearing impairment;hearing preservation;Hearing Protection;Hearing Tests;Human;hypercholesterolemia;Hyperlipidemia;improved;Incidence;Inferior;Intervention Studies;Intervention Trial;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Modeling;Mus;National Cancer Institute;Noise-Induced Hearing Loss;Observational Study;Odds Ratio;older adult;Oral;ototoxicity;Patient Outcomes Assessments;Patients;Peripheral Nervous System Diseases;permanent hearing loss;Pharmaceutical Preparations;Pilot Projects;Placebo Control;placebo group;Placebos;Platinum;Prevention strategy;primary outcome;Progression-Free Survivals;prospective;Publishing;Quality of life;quality of life for cancer survivors;Radiation;Radiation exposure;Radiation-Sensitizing Agents;Randomized;Safety;Schedule;Severities;sex;side effect;Site;survival outcome;Time;Tinnitus;Treatment Efficacy;trial design;Visit;Work

PROJECT_TITLE: Atorvastatin to Reduce Cisplatin-Induced Hearing Loss in Head and Neck Cancer Patients


NIH_SPENDING_CATS: Biotechnology;Cooley's Anemia;Gene Therapy;Genetics;Hematology;Orphan Drug;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: We have previously shown in mice and non-human primates that it possible to transduce hematopoietic stem cells in vivo and achieve therapeutic transgene expression levels that would be curative in patients with thalassemia or Sickle Cell Anemia. Here we propose to further de- risk and simplify our in vivo approach. Our ultimate goal is to deliver an off-the-shelf HSC gene therapy product to patients around the globe.

PI_NAMEs: LIEBER, ANDRE MICHAEL (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Adenoviruses;Aftercare;Ambulatory Care;antagonist;beta Thalassemia;Blood Cells;Bone Marrow;Bone Marrow Aspiration;Bone Marrow Purging;Capsid;Carmustine;CD46 Antigen;Cell Transplantation;Cells;cellular transduction;cesium chloride;chemotherapy;Clinical;clinical application;Communicable Diseases;cost;cost effectiveness;CRISPR/Cas technology;curative treatments;cytokine;Data;Defect;design;Developing Countries;disease model;Dose;driving force;efficacy study;Engineering;Erythrocytes;Erythroid Cells;Erythropoietin;Erythropoietin Receptor;Evaluation;Fetal Hemoglobin;fetal reactivity;gene therapy;Gene Transfer;gene transfer vector;Genes;Genetic;genome editing;Globin;Goals;Harvest;Hematological Disease;Hematopoietic Stem Cell Mobilization;Hematopoietic stem cells;Hemoglobinopathies;Hemophilia A;High Dose Chemotherapy;Human;humanized mouse;IL1R1 gene;Immunity;immunodeficiency;Immunotherapy;improved;In Vitro;in vivo;Injections;Intravenous;intravenous injection;Knock-out;Leukapheresis;Macaca mulatta;Mediating;Methods;Modification;mouse model;Mus;Mutation;nonhuman primate;Outcome;patient population;Patients;Peripheral;pharmacologic;Phenotype;portability;pre-clinical;preclinical study;preference;prevent;Price;Primates;Procedures;Process;Proliferating;Prophylactic treatment;Protocols documentation;Regimen;repaired;response;Risk;Safety;Series;Sickle Cell Anemia;side effect;Sleeping Beauty;stem cell gene therapy;stem cell genes;Stem cell pluripotency;Steroids;System;Technology;Testing;Thalassemia;thalassemia intermedia;therapeutic transgene;Toxic effect;Toxicology;trait;transgene expression;Transgenes;Transgenic Mice;Transposase;vector;Viral Vector;Virus

PROJECT_TITLE: In Vivo Hematopoietic Stem Cell Gene Therapy of Beta-Thalassemia and Sickle Cell Disease

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Alzheimer’s disease is a severely disabling brain disorder, exacting a significant toll on those afflicted and large personal, social, economic, and public health costs. The potential contributions of this research program include elucidating the neural mechanisms of cognitive deficits in Alzheimer’s disease, and developing a personalized, non-pharmacological intervention therapy for improving cognition in Alzheimer’s disease and related dementias.

PI_NAMEs: REINHART, ROBERT  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Activities of Daily Living;Affect;Age;Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Area;Behavioral;Brain;Brain Diseases;Cephalic;Code;Cognition;Cognitive;Cognitive deficits;cognitive function;Cortical Synchronization;cost;cost estimate;Coupled;Coupling;Data;Data Collection;Dementia;density;Deterioration;Development;disability;Disabling;Disease;Double-Blind Method;drug development;Economics;Electroencephalography;Electrophysiology (science);Ensure;executive function;experimental study;flexibility;Frequencies;functional disability;Functional disorder;Future;Goals;Health Care Costs;Human;Impairment;improved;indexing;Individual;Individual Differences;interest;Intervention;Investigation;Knowledge;long term memory;Maintenance;Measurement;Measures;Mediating;Memory;Memory impairment;Methods;mild cognitive impairment;Nature;Network-based;neural;neuromechanism;neurophysiology;neuroregulation;Neurosciences;Nonpharmacologic Therapy;novel;novel therapeutics;pathological aging;Pattern;Performance;Periodicity;Persons;Phase;Physiological;Population;power analysis;Prefrontal Cortex;Procedures;programs;Protocols documentation;Public Health;Quality of life;Randomized;reconstruction;Reproducibility of Results;Research;Research Personnel;Sample Size;Scheme;segregation;Short-Term Memory;social;Social Functioning;Source;Specificity;statistics;support network;Syndrome;System;Techniques;Temporal Lobe;Testing;theories;Therapeutic;Therapeutic Intervention;tool;translational neuroscience;translational progress;Validity of Results

PROJECT_TITLE: Personalized Synchronization of Cortical Rhythms to Improve Memory in Alzheimer's Disease

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Infectious Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: The goal is to give trainees performing basic science research an understanding of challenges involved in treating patients. One of the primary goals of our Program is to train Ph.D. students to understand clinical infectious diseases while acquiring the basic research knowledge and tools they will need to investigate and solve these problems through hypothesis-driven research. Programs that ensure that scientists understand the clinical implications of their research and facilitate the movement of scientific discoveries to the bedside are greatly needed in this country.

PI_NAMEs: ISBERG, RALPH R. (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Molecular Analysis;pathogenic microbe

PROJECT_TITLE: Molecular Analysis of Microbial Pathogens

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Neurosciences;Sleep Research

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative: Circadian rhythms are beneficial to health, whereas their disruption can increase risk of disease. The goal of this proposal is to uncover fundamental knowledge of how circadian rhythms are generated and coordinated between cells and organs outside of the brain, using genetic mouse models and molecular approaches. The knowledge gained will be critical to understand the adverse health effects associated with rhythm disruption and guide the develop of the most effective therapies to counteract circadian disruption.

PI_NAMEs: KORONOWSKI, KEVIN B (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TITLE: Fundamental Mechanisms of Higher-Order Circadian Rhythms

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative The GDAN represents an attempt to bring retrospective precision medicine to the NCI's clinical trial infrastructure. As such it is a great opportunity to learn why trials that have occurred worked at a broad level, or identify patients who likely benefited from therapy, even when the trials were not successful. Our participation in this network will bring the most robust approaches for mutation calling and expression analysis, will bring novel pathway analysis approaches, and will bring an analysis of tumor genetic heterogeneity and evolution.

PI_NAMEs: ELLROTT, KYLE  (contact);SPELLMAN, PAUL T.

PROGRAM_OFFICER_NAME: YANG, LIMING

PROJECT_TERMS: Acceleration;Address;Algorithms;Area;Bioinformatics;bioinformatics tool;Biological;Cancer Biology;Cancer Center;cancer genomics;cancer initiation;cancer prevention;cell free DNA;Charge;Clinical;clinical care;Clinical Trials;Clinical Trials Design;cluster computing;Communities;Competence;complex data;computer infrastructure;Computer software;computerized tools;Data;Data Analyses;data analysis pipeline;data integration;Data Set;Detection;Development;diagnostic biomarker;Disease;Distributed Systems;Dreams;Ensure;Evolution;experience;Future;genetic evolution;Genetic Heterogeneity;Genomic approach;genomic data;Genomics;Goals;Heterogeneity;improved;Individual;Infrastructure;innovation;Intervention;Knowledge;Learning;Malignant neoplasm of prostate;Malignant Neoplasms;Manuals;Messenger RNA;Methodology;Methods;multidisciplinary;Mutation;Neoplasm Metastasis;novel;novel diagnostics;novel strategies;Pathway Analysis;Pathway interactions;patient subsets;Patients;Pharmacologic Substance;precision medicine;Prevention strategy;Process;Prognostic Marker;programs;Quality Control;Research;Research Personnel;Resistance;response;Running;Sampling;Services;single-cell RNA sequencing;Site;Specialized Center;success;Survival Rate;System;Systems Integration;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;therapy resistant;Training;transcriptome sequencing;treatment strategy;tumor;tumor DNA;Update;Variant;Visualization;Work;working group

PROJECT_TITLE: OHSU Center for Specialized Data Analysis as part of the GDAN


ORG_CITY: Aurora

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The goal of this project is to determine the role of a new type of hybrid insulin peptide (HIP) containing insulin B-chain sequences. Discovery and characterization of B-chain HIPs and B-chain HIP-reactive T cells will be carried out in the Non-Obese Diabetic (NOD) mouse model of autoimmune diabetes. We will investigate whether B-chain HIPs can be used to induce antigen-specific tolerance in NOD diabetes and the presence of T cells reactive to B-chain HIPs in human T1D patients to develop new tetramers for tracking these T cells.

PI_NAMEs: HASKINS, KATHRYN M (contact);JAMES, EDDIE A

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Agonist;Antigens;Area;Autoantigens;Autoimmune Diabetes;Autoimmune Responses;autoreactive T cell;autoreactivity;Award;Beta Cell;Binding;C-Peptide;C-terminal;Categories;CD4 Positive T Lymphocytes;Clone Cells;Collaborations;combinatorial;Coupled;Cytoplasmic Granules;Data;Development;Diabetes Mellitus;diabetic;diabetogenic;Disease;Funding;Generations;Goals;granule cell;Human;human subject;Hybrids;Immunologics;Inbred NOD Mice;Infiltration;Insulin;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans Transplantation;Isogenic transplantation;Left;Manuscripts;Mass Spectrum Analysis;Modeling;mouse model;Mus;N-terminal;nanoparticle;neoantigens;Non obese;Pancreas;Pathogenesis;Pathogenicity;Patients;Peptide Library;Peptides;Peripheral Blood Mononuclear Cell;Population;prevent;Process;Productivity;Proteins;Reaction;Reagent;Research;Risk;Role;Structure of beta Cell of islet;T-Lymphocyte;Testing;Thymus Gland;tool;Work

PROJECT_TITLE: Hybrid Peptides as Autoantigens for Diabetogenic CD4 T Cells

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]