ORG_CITY: BOSTON

PHR: Project Narrative This project aims to better understand how cytotoxic T cell responses are regulated at immune effector sites during chronic viral infection or cancer, and to explore the mechanisms by which they can be functionally restored. Knowledge gained from these studies may lead to novel immunotherapeutic strategies.

PI_NAMEs: MEMPEL, THORSTEN ROMAN (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Adhesives;Adopted;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Antigens;Blood Vessels;cancer cell;Cell Differentiation process;Cells;chemokine receptor;Chronic;chronic infection;Clustered Regularly Interspaced Short Palindromic Repeats;Cross Presentation;Cues;CXCR3 gene;CXCR6 gene;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;Dendritic Cells;Disease;Distal;effector T cell;Endothelial Cells;Endothelium;Endowment;Epigenetic Process;Equilibrium;exhaust;exhaustion;Exposure to;Extravasation;fascin;Fibroblasts;functional adaptation;functional restoration;Gatekeeping;Grant;Heart;histological image;Histology;Homeostasis;Hot Spot;Human;Image Analysis;Immune;immune checkpoint;immune clearance;Immune system;Immunity;immunogenic;Immunologic Memory;Immunologics;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Inflammation;insight;Interleukin-12;Interleukin-15;intravital microscopy;Knowledge;Ligands;loss of function;Lymphocyte Activation;Lymphocyte antigen;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;Melanoma;Memory;migration;Modeling;multi-photon;Mus;Myelogenous;Natural Killer Cells;novel;nuclear factors of activated T-cells;Outcome;pathogenic virus;Pathway interactions;PD-1 blockade;Pericytes;Perivascular Neoplasm;Population;Population Dynamics;Positioning Attribute;prevent;programmed cell death protein 1;protein expression;prototype;quantitative imaging;receptor;recruit;Reporter;Reporting;response;restoration;Role;self-renewal;Shapes;Signal Transduction;Site;spatial relationship;stem;stem-like cell;T cell response;T cell transcription factor 1;T-Lymphocyte;T-Lymphocyte Subsets;TCF Transcription Factor;Testing;Tissues;tumor;Tumor Antigens;tumor growth;tumor microenvironment;Tumor Tissue;Viral;Viral Cancer;Virus;Virus Diseases;Work

PROJECT_TITLE: Cellular mechanisms by which exhausted T cell responses are restored

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: HS

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: IOWA CITY

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Approximating justice in solid organ allocation when balancing the competing goals of equity and utility remains an urgent public health challenge. By applying natural- and quasi-experiment design with causal inference framework using data from a well-established registry-based nationwide transplant cohort, this study elucidates the causal effect of the existing liver allocation policy related to geographic boundaries and particular age group (children and elderly) in the United States on liver transplant candidates and recipients, which will be critical in evaluating (health) policies in contexts where randomized trials are most often unrealistic. The findings and career development strategy will help prepare the applicant for an independent investigator with expertise in integrating health care policy and health services evaluation, epidemiology, and causal inference frameworks/econometrics with specific strengths in chronic liver disease and solid organ transplantation that addresses multiple sources of health disparity.

PI_NAMEs: TANAKA, TOMOHIRO  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Estimating the Causal Effect of Liver Allocation Policy Reflecting the Heterogeneity from Age and Geography

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Pediatric;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: MISCELLANEOUS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Trauma and post-traumatic stress disproportionately burden orphaned children in low-resource settings, and mental health services are often unavailable. While scale-up of interventions through lay counselor delivery of evidence-based treatments is promising, there is very limited knowledge on sustaining interventions after they are implemented or equipping leaders with information about potential effectiveness in other communities. This proposal, “Sustaining and Generalizing Evidence-based Mental Health interventions for children (SAGE-MH)” will innovatively expand an implementation effectiveness trial in western Kenya to examine strategies for continuation during sustainment and to assess generalizability to all orphaned children in Kenya.

PI_NAMEs: GRAY, CHRISTINE L (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Address;Adolescent;Adopted;Africa;Africa South of the Sahara;African;Age;Applied Research;Area;career networking;Characteristics;Child;Child Mental Health;Cognitive Therapy;Communities;Competence;Country;Data;Demographic and Health Surveys;Development;disorder prevention;Dissemination and Implementation;Education;Effectiveness;effectiveness-implementation randomized trial;effectiveness/implementation trial;Elements;Ensure;evidence base;Evidence based treatment;experience;feasibility research;Funding;Goals;Health;Health Personnel;implementation efforts;implementation research;improved;Incidence;Infrastructure;innovation;interest;Intervention;intervention effect;Interview;K-Series Research Career Programs;Kenya;Knowledge;long-term sequelae;low and middle-income countries;Maps;Mental Health;Mental Health Services;Mentors;Mentorship;Methods;Modeling;National Institute of Mental Health;Orphan;Outcome;Parents;Partnership Practice;Pathway Analysis;Patient Self-Report;Persons;Phase;Policies;Policy Maker;Population;post implementation;post-traumatic stress;Productivity;Professional counselor;programs;Provider;Public Health;Qualitative Methods;randomized, clinical trials;Reading;Research;Research Personnel;Research Priority;Research Project Grants;Resource-limited setting;Resources;scale up;Science;Scientist;Senior Scientist;service gap;Site;skills;Social Network;Strategic Planning;Supervision;Surveys;System;Target Populations;Testing;Time;tool;Training;Trauma;trauma exposure;traumatic event;United States National Institutes of Health;Work

PROJECT_TITLE: SAGE Mental Health

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Dr. Page conducts research addressing barriers to evidence-based care to vulnerable populations through community-engaged program building and evaluation. The objectives of this proposal are to support a program for mentoring junior investigators and to foster innovative epidemiologic and implementation science research. The overall goal of this work is to train a diverse new generation of health equity researchers and to bridge the gap between knowledge and practice by ensuring that medical and research advances are available to those who need them the most.

PI_NAMEs: PAGE, KATHLEEN R (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: Address;Adoption;Applied Skills;Award;behavior change;Behavioral;bilingualism;career;Caring;Classification;Clinic;clinical care;Communicable Diseases;Communities;community based research;community building;community engaged approach;community engaged research;community engagement;Community Health Aides;Consolidated Framework for Implementation Research;COVID-19;COVID-19 pandemic;Data Aggregation;Data Collection;Dedications;digital;Discrimination;disorder risk;Economics;effectiveness research;Electronics;Ensure;Environment;Epidemiology;equity, diversity, and inclusion;Ethnic Origin;Ethnic Population;Evaluation;evidence base;Exclusion;experience;Faculty;Family;Fostering;Friends;Funding;Future;Generations;Goals;Health;health disparity;health equity;health equity promotion;Health Insurance;health literacy;Health Services;Health Services Accessibility;Health system;Healthcare;Healthcare promotion;high risk;Hospitalization;Hotlines;Hybrids;Immigration;implementation determinants;implementation evaluation;implementation outcomes;implementation research;implementation science;Improve Access;improved;Incentives;Inequity;Infrastructure;innovation;Institution;interest;Intervention;Interview;Knowledge;Language;Latino;Latino Population;Leadership;Learning Skill;Limited English Proficiency;Linguistics;Low income;Maintenance;marginalized population;Medical;Medicine;Mentors;Methodology;Methods;mHealth;mid-career faculty;Migrant;migration;Modeling;Motivation;Not Hispanic or Latino;Online Systems;Outcome;pandemic disease;Pathway Analysis;peer;Persons;Policies;Population;Poverty;programs;Public Health;public health research;Race;RADx Underserved Populations;recruit;Reduce health disparities;reinforced behavior;Research;Research Personnel;research study;Resources;Sampling;SARS-CoV-2 exposure;Science;Scientific Advances and Accomplishments;skills;social;Social Network;social network intervention;social stigma;socioeconomics;Specialist;stressor;Structure;Students;success;Surveys;Technology;Testing;Text Messaging;theories;Time;Touch sensation;Training;training opportunity;Trust;Underserved Population;United States National Institutes of Health;uptake;Vaccinated;Vaccination;Vulnerable Populations;Work

PROJECT_TITLE: Mentoring in Community-engaged Research to Promote Health Equity for Latinos

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(83)]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Organ Transplantation;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Transplant outcomes remain suboptimal, driven in part by episodes of T cell-dependent rejection. Activation of the complement system post-transplant as well as allograft-released exosomes are involved in priming anti- donor T cell immunity. We will study the mechanisms linking complement activation to exosome function and generation of pathogenic cellular immune responses and graft rejection.

PI_NAMEs: CHUN, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: activation product;Acute;allograft rejection;Allografting;Antigen-Presenting Cells;Binding;Biology;Blocking Antibodies;C3bi;CD11c Antigens;Cells;Cellular Immunity;Chronic;Clinical Trials;Complement;Complement 3b;Complement 4b;Complement Activation;Complement Degradation;complement pathway;Complement Receptor;complement system;Data;Dendritic Cells;Deposition;Development;Disease;Dual-role transvestism;exosome;experimental study;Frequencies;Gene Expression Profile;Generations;Genetic;Graft Rejection;Graft Survival;Health;Heart failure;Human;human model;Immune;Immune response;Immunity;immunogenicity;improved;In Vitro;in vivo;in vivo Model;inhibitor;Injury;innovation;insight;Integrin alphaXbeta2;ITGAX gene;Knock-out;Lead;Ligation;Link;Major Histocompatibility Complex;Mannose Binding Lectin;Mediating;Mediator;Modeling;Morbidity - disease rate;mouse model;Mus;new therapeutic target;novel;Opsonin;Organ Donor;Outcome;Pathogenicity;Pathway interactions;Patients;Peptides;pharmacologic;Plasma;post-transplant;prevent;Process;process optimization;Publishing;Reaction;receptor;Reporting;Research;Resistance;Role;Sampling;secondary lymphoid organ;Surface;System;T cell response;T memory cell;T-Cell Activation Pathway;T-Lymphocyte;Testing;therapeutic target;Transplant Recipients;Transplantation;treatment strategy

PROJECT_TITLE: Complement-Mediated Exosome Function in Transplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Gene Therapy;Genetics;Liver Disease;Orphan Drug;Rare Diseases

ORG_DEPT: PEDIATRICS

PHR: Developing genome editing in Pompe disease will provide benefits in comparison with standard of care enzyme replacement therapy, including the stable correction of skeletal muscle and enhanced quality of life, thereby addressing an unmet need.

PI_NAMEs: KOEBERL, DWIGHT D (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Acceleration;Acids;Address;adeno-associated viral vector;Adult;Antibodies;Antibody Response;Biochemical;Blood;Circulation;Clinical Trials;Dependovirus;design;Development;Disease;Early treatment;Enrollment;enzyme replacement therapy;experience;Future;gene replacement therapy;gene therapy;Genes;Genetic Recombination;genome editing;Glucan 1,4-alpha-Glucosidase;glucosidase;Glycogen;Glycogen storage disease type II;Goals;Heart;Human;Immune response;Immunosuppression;improved;In complete remission;In Vitro;in vivo;infancy;Infant;intravenous administration;Life;Liver;Mediating;Metabolic Diseases;Methods;Modeling;mouse model;Mus;Muscle;Muscle function;Muscle Weakness;Muscular Atrophy;Myocardium;Nervous System;novel therapeutics;Patients;Pharmaceutical Preparations;Phase I Clinical Trials;Population;pre-clinical research;prevent;Production;Quality of life;receptor;Recombinants;Regimen;Regulatory T-Lymphocyte;Skeletal Muscle;standard of care;Symptoms;Testing;Therapeutic;therapeutic genome editing;therapeutic transgene;therapy development;Transgenes;Translating;uptake;Variant;vector;vector genome

PROJECT_TITLE: Stable therapy in Pompe disease through genome editing

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Mitochondrial dysfunction is involved in the pathogenesis of the major blinding retinal diseases such as diabetic retinopathy and age-related macular degeneration, but study on mitochondria in retinal vasculature is limited. We will employ genetic, biochemical, cell biology, microscopy imaging and single cell transcriptome analyses to define the common angiogenic and metabolic pathways regulated by three mitochondrial proteins with distinct functions. Successful completion of the proposed aims will facilitate our understanding of the molecular mechanisms and pathogenesis involved in vascular diseases in the eye, and help in defining more effective therapies. 1

PI_NAMEs: ZHOU, JENNY HUANJIAO (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: 3-Dimensional;Age;Age related macular degeneration;aged;Aging;Aneurysm;angiogenesis;Apoptosis;Arteriovenous malformation;Attenuated;Biochemical;Biological Assay;Blindness;blood vessel development;Blood Vessels;Canes;Cardiovascular Diseases;Cell Proliferation;Cells;Cellular biology;Coats' disease;complex IV;Cues;Data;Defect;Diabetes Mellitus;Diabetic Retinopathy;Diving;DNA Sequence Alteration;effective therapy;Elderly;Endothelial Cells;Exhibits;Eye;Familial exudative vitreoretinopathy;Feedback;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;Glycolysis;Glycolysis Pathway;Growth;Human;Hypertension;Hypervascular;Impairment;In Vitro;inhibitor;malformation;MAP Kinase Gene;MAPK8 gene;Mediating;Metabolic Pathway;Microaneurysm;microscopic imaging;Military Personnel;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;Mus;Mutant Strains Mice;novel;Nuclear;Oxidation-Reduction;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathologic;Pathway interactions;Penetration;Pericytes;pharmacologic;Phenotype;Phosphorylation;postnatal;Process;Production;Proliferating;Proteins;recruit;Respiration;respiratory;Retina;retina blood vessel structure;Retinal Diseases;Role;Signal Transduction;single-cell RNA sequencing;Stroke;Structure;TGF-beta type I receptor;Therapeutic Intervention;Thioredoxin-2;transcription factor;transcriptome;vascular abnormality;Vascular Diseases;Vascular Endothelial Cell

PROJECT_TITLE: Investigating the role of mitochondrial dysfunction in the pathogenesis of retinal vascular diseases

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Gene Therapy;Genetics;Kidney Disease;Liver Disease;Nanotechnology;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The proposed research will investigate fetal growth restriction-associated developmental programming in fetal liver and kidney with and without treatment of the placenta with a nanoparticle gene therapy, and explore the impact on offspring liver and kidney physiology/function and health in early adulthood.

PI_NAMEs: WILSON, REBECCA L (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Adolescence;Adult;Affect;Amino Acid Transporter;Angiotensins;Animals;Area;blood pressure regulation;cancer therapy;Cardiovascular Diseases;Cavia;Cell Culture Techniques;Cells;Central obesity;Cessation of life;Clinical;clinical diagnostics;Coculture Techniques;Collagen;Communication;Data;Deposition;Development;Diabetes Mellitus;Diagnostic Procedure;Disease;drug metabolism;emerging adult;Endocrine;experimental study;Female;fetal;fetal blood;Fetal Development;Fetal Growth;Fetal Growth Retardation;Fetal Kidney;Fetal Liver;fetal programming;Fetal Tissues;Fetal Weight;Fetus;Fibrosis;Foundations;Functional disorder;Gene Expression;Gene Expression Profiling;gene therapy;Genomics;Glucose;Growth Factor;Health;healthy pregnancy;Hepatocyte;Human;Human Cell Line;Hypertension;Hypoxia;IGF1 gene;improved;in utero;Inflammation;innovation;Insulin-Like Growth Factor I;Intervention;Investigation;Kidney;kidney cell;kidney dysfunction;Knowledge;Late pregnancy;Life;Life Cycle Stages;liquid chromatography mass spectrometry;Liver;Liver Dysfunction;male;maternal nutrient restriction;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;metabolomics;Mitochondria;Modeling;Mothers;nanoparticle;Non-Insulin-Dependent Diabetes Mellitus;non-viral gene delivery;offspring;Operative Surgical Procedures;Organ;Pathway interactions;Perinatal;Physiological;Physiology;Placenta;placental trophoblasts;Polymers;postnatal;Pregnancy;prevent;protein expression;Quality of life;Quality-Adjusted Life Years;Renin;Reproductive Medicine;Research;Respiratory Disease;Risk;Series;Signal Pathway;Signal Transduction;Technology;Testing;Therapeutic Intervention;Third Pregnancy Trimester;Tissues;Toxic effect;transcriptome;transcriptome sequencing;uptake

PROJECT_TITLE: Developmental Programming of the Liver and Kidney in Fetal Growth with or without Gene Therapy

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: OVERALL | PROJECT NARRATIVE The CLEAR Consortium is a unique multi-disciplinary team of clinicians, geneticists, computational scientists, developmental and stem cell biologists using an innovative combination of patient genome sequencing, neonatal MRI, animal models, single cell genomics, and human organoids. Our goal is to discover the developmental mechanisms of life-threatening trachea-esophageal birth defects to better understand their etiology, enhance diagnosis, improve treatment, and inform strategies to generate tissue in vitro for repair.

PI_NAMEs: CHUNG, WENDY K;KINGMA, PAUL SCOT;SHEN, YUFENG ;WELLS, JAMES M;ZORN, AARON M (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Animal Model;Animals;Automobile Driving;Award;Bioinformatics;Birth;Breathing;causal variant;Cellular biology;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;comorbidity;Congenital Abnormality;data integration;Databases;Defect;Development;Diagnosis;Doctor of Philosophy;Educational workshop;embryo tissue;Embryology;Esophageal Atresia;Esophagus;Etiology;Event;experience;feeding;Fetal Development;Gene Mutation;Genes;Genetic;genome sequencing;Genomics;Genotype;Goals;Human;improved;In Vitro;innovation;Institution;Investigation;Life;Link;Magnetic Resonance Imaging;meetings;Methods;Mining;Modeling;Molecular;Morphogenesis;mouse genetics;multidisciplinary;Mutation;neonatal magnetic resonance imaging;Newborn Infant;novel;Organoids;Paper;patient advocacy group;Patients;Pediatric Hospitals;Phenotype;prevent;Primitive foregut structure;programs;Publishing;Registries;repaired;Reporting;Research Personnel;Resources;risk variant;Role;Scientist;single cell genomics;stem cells;success;Surgeon;synergism;Techniques;Technology;Testing;Tissue Engineering;Tissues;Trachea;Trachea-esophageal birth defects;Tracheoesophageal Fistula;Tube;United States National Institutes of Health;Variant;web site;Xenopus

PROJECT_TITLE: CLEAR Consortium: Discovering the Developmental Mechanisms of Trachea-Esophageal Birth Defects


NIH_SPENDING_CATS: Congenital Structural Anomalies;Infant Mortality;Lung;Pediatric

PI_NAMEs: ZORN, AARON M (contact)

PROJECT_TERMS: Academic Medical Centers;Administrator;Basic Science;Budgets;Clinic;Clinical;Clinical Research;Collaborations;Communication;Communities;Community Outreach;Development;Developmental Biology;Effectiveness;Ensure;Esophageal Atresia;Esophagus;experience;Genomics;Goals;Institution;interest;International;Medical;Medical center;Medical Research;meetings;Monitor;multidisciplinary;Netherlands;Occupational activity of managing finances;outreach;participant enrollment;patient advocacy group;patient engagement;Pediatric Hospitals;performance site;programs;Progress Reports;Reporting;Research;Resources;Scientific Evaluation;Site;success;Surgeon;symposium;Trachea-esophageal birth defects;United States National Institutes of Health;virtual;web site;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Data Science;Genetics;Human Genome;Lung;Pediatric

PI_NAMEs: SHEN, YUFENG  (contact)

PROJECT_TERMS: Acceleration;Address;animal data;Animal Model;Animals;Binding;Bioinformatics;Biological;Candidate Disease Gene;candidate identification;Cardiac;causal variant;Cells;Child;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;Clinical Data;Communities;Computer Analysis;Computing Methodologies;Congenital Abnormality;Copy Number Polymorphism;cost effective;Data;Data Discovery;data dissemination;data integration;data management;data mining;Data Set;data sharing;Databases;de novo mutation;Deposition;Development;developmental genetics;Disease;disorder risk;Endocytosis;Epigenetic Process;Etiology;exome;exome sequencing;experimental study;functional genomics;Funding;gastrointestinal;Gene Expression Profile;Genes;Genetic;genetic analysis;genetic testing;Genetic Transcription;Genitourinary system;Genome;genome analysis;genome sequencing;genomic data;Genomics;Genotype;Goals;Human;human data;human induced pluripotent stem cells;in silico;Informatics;Infrastructure;insertion/deletion mutation;literacy;Manuscripts;model organisms databases;Multiomic Data;Neurologic;Organoids;Parents;Pathway interactions;Patients;Pediatric Research;Phenotype;proband;programs;Proteins;public repository;Publications;rare variant;Registries;risk variant;RNA analysis;Sample Size;Services;single cell genomics;Single Nucleotide Polymorphism;single-cell RNA sequencing;Statistical Data Interpretation;Statistical Methods;success;synergism;Testing;Trachea-esophageal birth defects;trafficking;transcription factor;transcriptome sequencing;United States National Institutes of Health;Variant;whole genome;Xenopus

PROJECT_TITLE: Integrated Genomics Core


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Digestive Diseases;Genetics;Human Genome;Infant Mortality;Lung;Pediatric

PI_NAMEs: CHUNG, WENDY K (contact)

PROJECT_TERMS: 3-Dimensional;Accounting;Anatomy;Animal Model;Animals;autism spectrum disorder;Biological Models;Birth;Breathing;Candidate Disease Gene;catalyst;Cells;Clinical;clinical diagnostics;clinical investigation;Clinical Pathology;clinical phenotype;Collaborations;comorbidity;Congenital Abnormality;congenital anomaly;Congenital diaphragmatic hernia;congenital heart abnormality;Craniofacial Abnormalities;Data;Databases;Defect;Development;Developmental Biology;developmental disease;Diagnosis;Diagnostic;DNA Sequence Alteration;Early Intervention;Effectiveness;Enrollment;Esophageal Atresia;Esophageal motility disorders;Esophagus;Etiology;feeding;Fetal Development;Fistula;functional genomics;Genes;Genetic;Genetic Diseases;genetic disorder diagnosis;Genetic Predisposition to Disease;genetic variant;genome sequencing;genomic data;Genomics;Genotype;Goals;Growth;Human;improved;Inherited;Intervention;Laboratories;Left;Life;Liquid substance;Magnetic Resonance Imaging;malformation;Measurement;Measures;Medical;Molecular;Mutation;mutation carrier;neonate;Neurodevelopmental Disorder;novel;Operative Surgical Procedures;Organ;Organoids;Outcome;Parents;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;Phenotype;Prenatal Diagnosis;Primitive foregut structure;proband;Prognosis;programs;Registries;repaired;Research;Respiratory physiology;risk variant;Sample Size;Statistical Data Interpretation;Testing;Trachea;Trachea-esophageal birth defects;tracheomalacia;transcriptomics;treatment strategy;Variant;whole genome;Xenopus

PROJECT_TITLE: Project-1: Comprehensive phenotypic and genetic assessment of TE birth defects in patients


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Infant Mortality;Lung;Pediatric

PROJECT_TERMS: Adhesions;Animal Model;Animal Testing;Animals;Automobile Driving;Award;Cadherins;Cardiac;causal variant;Cell Adhesion;cell behavior;Cells;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Computer Analysis;Confocal Microscopy;CRISPR screen;Data;Defect;Development;Embryo;Embryology;Endosomes;Ephrins;Epithelium;Esophagus;Event;experimental study;Failure;fetal;FOXF1 gene;functional genomics;Genes;Genetic Epistasis;Genetic Predisposition to Disease;Genetic Transcription;Genome;genome sequencing;Genomics;Genotype;GLI3 gene;Goals;Human;human data;Intercellular Junctions;Life;loss of function;Mediating;Membrane;Mesenchyme;Mesoderm;migration;Modeling;Morphogenesis;Mus;Mutagenesis;mutant;Mutation;neural;Nucleotides;Pathogenicity;Pathologic;Pathway Analysis;Pathway interactions;Patient risk;Patients;Phenotype;Primitive foregut structure;programs;Proteins;Publishing;Regulation;Resolution;risk variant;screening;Signal Transduction;single cell genomics;single-cell RNA sequencing;Site;smoothened signaling pathway;Testing;Tissues;Trachea;Trachea-esophageal birth defects;trafficking;transcription factor;Transcriptional Regulation;Tube;Variant;Vesicle;Xenopus

PROJECT_TITLE: Project-2: Modeling TE birth defects in animals


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Digestive Diseases;Genetics;Infant Mortality;Lung;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: WELLS, JAMES M (contact)

PROJECT_TERMS: Achalasia;Acids;Address;Affect;antagonist;Autologous;Biopsy;cell type;Cells;ChIP-seq;Colon;Computer Analysis;constriction;Data;Defect;Development;Distal;Dorsal;embryo tissue;Endoderm;Engineering;Enteric Nervous System;Enzymes;Epithelium;Esophageal Atresia;Esophageal Tissue;Esophagus;Fanconi Anemia Complementation Group A Protein;Food;FOXF1 gene;Funding;Future;Gastrointestinal tract structure;Gene Expression Profiling;gene function;Gene Mutation;Genes;Genetic Transcription;Genomics;Germ Layers;HMG-Box Domains;Hormone secretion;Human;Human Engineering;human pluripotent stem cell;Impairment;induced pluripotent stem cell;Ingestion;Injury;loss of function;MADH6 gene;Malignant neoplasm of esophagus;Megaesophagus;Mesenchymal;Mesenchyme;Mesoderm;Microbe;Modeling;Morphogenesis;Motility;motility disorder;Movement;Mus;Muscle;Muscle Contraction;Mutation;nervous system development;neural;Neurons;novel;nutrient absorption;Oral cavity;Organoids;Patients;Pluripotent Stem Cells;Primitive foregut structure;programs;Publishing;reconstruction;Reconstructive Surgical Procedures;Repression;response;risk variant;Role;single-cell RNA sequencing;Smooth Muscle;Source;Stomach;Stratified Epithelium;System;Testing;Tissues;Toxin;Trachea-esophageal birth defects;Tracheoesophageal Fistula;transcription factor

PROJECT_TITLE: Project-3: Modeling EA/TEF in human organoids


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Hepatitis - C;Infectious Diseases;Liver Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Despite the availability of highly effective HBV vaccine and HCV treatment, their infections are still among the leading causes of chronic liver disease worldwide. We propose to utilize an innovative platform to address several clinically important but understudied questions including a continued disease progress following cure of HCV infection, an accelerated disease progression with HBV/HCV co-infection, HBV reactivation following cure of HCV, and how genetic variants affect the course of disease and treatment. These studies will not only provide new insights that could inform development of effective diagnostics and treatments for HBV/HCV infection, but also lead to technology advance that open up new avenues for future studies focusing on other liver diseases.

PI_NAMEs: WU, XIANFANG  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute Liver Failure;Address;Affect;Age;aging population;Anti-viral Agents;Area;career;Cell Communication;Cell Culture Techniques;Cell Differentiation process;Cell Line;cell type;Cells;Cellularity;Chronic Hepatitis B;chronic infection;chronic liver disease;Cirrhosis;Clinical;co-infection;Coculture Techniques;Complex;CRISPR/Cas technology;Development;Diagnostic;Disease;disease phenotype;Disease Progression;DNA sequencing;Endothelial Cells;Epidemiology;epigenomics;Fibrosis;Foundations;Future;gene editing technology;Genes;Genetic;genetic variant;Genetic Variation;genome wide association study;Goals;hemodynamics;Hepatic;Hepatic Stellate Cell;Hepatitis A;Hepatitis B;Hepatitis B Infection;Hepatitis B Therapy;Hepatitis B Vaccines;Hepatitis B Virus;Hepatitis C;Hepatitis C co-infection;Hepatitis C Therapy;Hepatitis C virus;Hepatitis D;Hepatitis E virus;Hepatitis Viruses;Hepatocyte;Heterogeneity;high risk;Human;human model;human pluripotent stem cell;IL18 gene;improved;In Vitro;in vivo;Individual;individual variation;Infection;infection risk;innovation;insight;Kupffer Cells;Link;Liver;Liver diseases;liver transplantation;Macrophage;Mediating;Methods;Modeling;Molecular;mortality;Natural Immunity;novel;Outcome;Patients;Persons;Population;post-doctoral training;Primary carcinoma of the liver cells;Reporting;Research;response;Risk;Sampling;Severities;Single Nucleotide Polymorphism;stem;stem cells;System;Technology;three dimensional cell culture;Time;Tissue Engineering;transcriptomics;Translating;transmission process;Treatment outcome;United States;Viral;Viremia;Virus;Work

PROJECT_TITLE: Developing a renewable and dissectible human liver for the study of HBV/HCV infection


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: Decision-making is disrupted in psychiatric disorders including schizophrenia & bipolar disorder.Moreover,  all major classes of psychiatric disorders are associated with disordered reward processing in the brain.  Therefore, a circuit-level understanding of how the brain computes and represents the reference point  during value-based decision-making has enormous consequences for human health, and may hold  promise for improving treatments for mental health disorders in which decision-making is impaired.

PI_NAMEs: CONSTANTINOPLE, CHRISTINE M (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Affect;Animal Model;Animals;Architecture;Automobile Driving;Behavior;behavior measurement;Behavioral;behavioral economics;Behavioral Model;Behavioral Paradigm;Biological Models;Bipolar Disorder;Birds;Brain;Capuchin Monkey;Choice Behavior;Chronic;Cognitive;Collaborations;Complex;Data;Decision Making;Decision Theory;Dependence;Dimensions;Disease;dynamic system;expectation;experience;experimental study;Future;Health;Human;Impairment;Implant;improved;Individual;Individual Differences;Insurance;Knowledge;Machine Learning;Mammals;Mental disorders;Modeling;Modernization;Monitor;neural;neural circuit;Neurons;neuropsychiatric disorder;novel;Occupations;Outcome;Persons;Population;Population Dynamics;preservation;Process;Rattus;Recording of previous events;recurrent neural network;Retirement;reward processing;Rewards;Savings;Schizophrenia;Silicon;Structure;Techniques;Testing;tool;Training;Wages;Water;Work

PROJECT_TITLE: CRCNS: Inferring reference points from OFC population dynamics


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: Aurora

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE Cellular responses to external stimuli require dynamic gene regulation to facilitate rapid activation and effective resolution. Our MIRA program will yield new insights into how post-transcriptional regulatory mechanisms driven by RNA-binding proteins control the kinetics of stimulus-induced gene expression programs.

PI_NAMEs: MUKHERJEE, NEELANJAN  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Adrenal Glands;Aldosterone;Angiotensin II;Attenuated;Binding;Binding Proteins;Biological Models;Blood Pressure;Cells;Cholesterol;cytokine;Ensure;Gene Expression;Gene Expression Regulation;Genetic Transcription;Goals;Human;immune activation;innovation;insight;Kinetics;Ligands;Messenger RNA;Methods;mRNA Decay;mRNA Expression;mRNA Translation;Pattern;Peptides;Phenotype;Physiologic pulse;Play;Post-Transcriptional Regulation;posttranscriptional;Prevention;Production;programs;receptor;Research;Resolution;response;RNA;RNA Decay;RNA Processing;RNA-Binding Proteins;Role;Steroid biosynthesis;Stimulus;System;Testing;Textbooks;Translations;ZFP36L2 gene;Zona Glomerulosa

PROJECT_TITLE: Temporal coordination of stimulus-induced gene expression by RNA-binding proteins

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: PHILADELPHIA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROGRAM NARRATIVE We propose a new Surgical Oncology Research Training Program at the University of Pennsylvania. The goal is to train surgeon-scientists to perform independent cancer research upon completion of their clinical surgical training.

PI_NAMEs: DEMATTEO, RONALD P. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Research Training;Surgical Oncology;Training Programs

PROJECT_TITLE: SURGICAL ONCOLOGY RESEARCH TRAINING PROGRAM AT PENN

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Disability Research;Mental Health;Mental Illness;Pain Research;Patient Safety;Pediatric

ORG_CITY: CHAPEL HILL

ORG_DEPT: DENTISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE. Determining whether Animal-Assisted Therapy (AAT) could serve as a low risk, efficacious approach for managing dental anxiety and providing positive dental experiences in children would allow for rapid implementation of canine therapy in dentistry. We will evaluate whether short and long AAT interventions alleviate stress and improve perceptions during preventative pediatric dental care, to guide AAT protocol development and use to improve lifelong oral health with broad public health impact.

PI_NAMEs: JACOX, LAURA ANNE (contact)

PROGRAM_OFFICER_NAME: ELWOOD, WILLIAM N

PROJECT_TERMS: active control;Adult;Adverse event;adverse event risk;Affect;Age;age group;alpha-amylase;Anesthesia procedures;animal efficacy;animal-assisted therapy;Animals;Anxiety;anxiety management;anxiety reduction;Appointment;Arousal;Behavior;Behavioral;Biometry;Canis familiaris;Caregivers;Caring;Cessation of life;Child;Childhood;Clinical Trials;Code;cohort;Collaborations;comparison control;Computer software;Data;Data Analyses;Dementia;Dental;Dental Anxiety;Dental Care;Dentistry;Dentists;Devices;Diagnostic;Discipline;Elderly;Emergent care;Emotional;Ensure;Evaluation;Exhibits;expectation;experience;Facial Pain;Faculty;Fright;Funding;Future;Galvanic Skin Response;General Anesthesia;Health;health care settings;health related quality of life;Heart Diseases;Heart Rate;Hormones;Hospitalization;Hydrocortisone;improved;Individual;Infection;innovation;Inpatients;Intervention;Intravenous;Lead;Learning;Licensing;Literature;Malignant Neoplasms;Measurement;Measures;Medical;Methodology;Minor;Movement;Nervous System Trauma;novel;Oral;Oral health;Outcome;Outpatients;Pain;pain perception;Parents;Pathological anxiety;Patient Self-Report;Patients;Pediatric Dentistry;pediatric patients;Perception;Persons;pharmacologic;Physiological;Population;Preventive treatment;protocol development;Protocols documentation;Public Health;Qualifying;Quality of life;Questionnaires;Randomized;randomized, clinical trials;response;restraint;Risk;saliva sample;Salivary;Sampling;Sedation procedure;sedative;self-reported anxiety;Stress;Surveys;Techniques;Testing;Therapeutic;Therapeutic Intervention;Toothache;Training;Visit;Work

PROJECT_TITLE: Evaluating the Effects of Animal Therapy on Anxiety in Pediatric Dental Patients

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Kinase plus LSD1 inhibition is a new treatment approach for patients with AML, in whom kinase inhibitor monotherapy has not historically provided a large clinical benefit. In this proposal, we will investigate the mechanism of action of FLT3 plus LSD1 and MEK plus LSD1 inhibition in FLT3- and NRAS-mutant AML respectively. These studies will provide a pre-clinical framework for the clinical translation of kinase plus LSD1 inhibitor therapy for patients with AML.

PI_NAMEs: BRAUN, THEODORE PAUL (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;antileukemic activity;Automobile Driving;Binding;cancer cell;Cell Cycle;Cell Death;Cell Line;Characteristics;Chromatin;Clinical;clinical translation;Clinical Treatment;Clinical Trials;Complex;Correlative Study;Data;Development;Disease;Drug Combinations;Drug Synergism;Drug Targeting;effective therapy;efficacy evaluation;Enhancers;Epigenetic Process;epigenetic profiling;Evaluation;FLT3 gene;FLT3 inhibitor;Gene Expression;Genes;Granulocyte Colony-Stimulating Factor Receptors;improved;inhibitor;inhibitor therapy;Investigation;JAK2 gene;KDM1A gene;kinase inhibitor;Link;Mediating;MEKs;member;Minority;Molecular;molecular subtypes;mouse model;mutant;Mutation;MYC Family Protein;MYC gene;novel therapeutic intervention;Oncogenic;Outcome;participant enrollment;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phase Ib Trial;Phosphotransferases;Play;pre-clinical;preclinical efficacy;programs;promoter;Refractory;Regulation;Relapse;Repression;Resistance;response;Role;Sampling;Signal Pathway;Signal Transduction;Stat5 protein;synergism;Testing;Therapeutic;transcription factor;Translating;treatment response;Tyrosine Kinase Inhibitor;Work

PROJECT_TITLE: Dual Kinase and LSD1 Inhibition in Acute Myeloid Leukemia


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Los Angeles

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because identifying pathological alterations to the brain glia- lymphatic pathway (i.e. perivascular spaces) is expected to aid in Alzheimer’s disease diagnosis and disease monitoring. It is also expected to fill the gap in knowledge regarding the role of the perivascular spaces in Alzheimer’s disease and its pathological neuroimaging signature. Thus, this proposal is relevant to the part of NIA's mission that pertains to fostering aging research and further characterizing the aging brain in Alzheimer’s disease.

PI_NAMEs: CHOUPAN, JEIRAN  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta accumulation;abeta deposition;Address;Affect;Age;age related changes;Aging;aging brain;aging related disease;Agreement;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;American;Amyloid beta-Protein;Animals;aquaporin 4;Area;arteriole;Astrocytes;Basal Ganglia;Biological;biophysical properties;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;Brain;brain health;cardiovascular risk factor;Cerebrospinal Fluid;Characteristics;Clinical;Cognitive;cohort;computational suite;Computational Technique;connectome;Data;Databases;Dementia;Deposition;Diabetes Mellitus;diagnostic tool;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Drainage procedure;Early Diagnosis;Exclusion;Fostering;Functional disorder;Funding;glymphatic system;Goals;healthy aging;Human;human data;hyperphosphorylated tau;Hypertension;Image;Image Analysis;Imaging Device;imaging facilities;Impaired cognition;Impairment;improved;in vivo;Individual;innovation;insight;Intercellular Fluid;interest;Knowledge;Liquid substance;Lymphatic;Magnetic Resonance Imaging;Maps;Measurement;Metabolic;Microvascular Dysfunction;Mission;Modality;Modeling;Monitor;Morphology;Nervous System Disorder;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuroimaging;neurovascular;normal aging;Outcome;Outcome Measure;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Physiological;Population;Predisposition;Property;Proteins;Public Health;Radiology Specialty;Regional Anatomy;Research;Research Personnel;Resolution;Resources;Risk Factors;Role;secondary analysis;structural imaging;Structure;tau Proteins;Techniques;Testing;Time;Tissues;United States National Institutes of Health;uptake;Variant;vascular cognitive impairment and dementia;vascular risk factor;venule;Visual;wasting;Work

PROJECT_TITLE: Structural and diffusion changes of perivascular space in aging, cognitive decline and Alzheimer's disease

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Acute myeloid leukemia (AML) in children, adolescents, and young adults (AYA) is characterized by highly prevalent transcription factor fusions and RAS pathway mutations with the first of these genetic alterations hypothesized to promote a transcriptional signature that is permissive for AML development and the latter playing a central role in driving leukemic growth. Our data revealed that targeting these pathways simultaneously results in potent synergistic effects that converge upon key survival programs. This K08 application proposes to extend these studies to pediatric AML patient-derived xenografts and to define the molecular basis of drug synergy and resistance with the goal of translating this new knowledge into better treatments for pediatric AML.

PI_NAMEs: HUANG, BENJAMIN  (contact)

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adolescent and Young Adult;Adult Acute Myeloblastic Leukemia;Alternative Therapies;Apoptosis;Automobile Driving;Biological Models;Bromodomain;Bromodomains and extra-terminal domain inhibitor;candidate validation;Cell Line;Chemotherapy-Oncologic Procedure;Child;Childhood Acute Myeloid Leukemia;Childhood Leukemia;Clinical;cohort;Combined Modality Therapy;congenic;CRISPR interference;Data;Dependence;Development;Diagnosis;DNMT3a;Drug Combinations;Drug resistance;Drug Synergism;drug testing;Engraftment;Epigenetic Process;experimental study;Gene Expression Profile;Genes;Genetic;Genetic Heterogeneity;Genetic Transcription;genome-wide analysis;Genomics;Goals;Growth;Human;hyperactive Ras;Immunocompetent;improved;in vivo;inhibitor;Insertional Mutagenesis;knock-down;Knowledge;KRAS2 gene;Laboratories;leukemia;leukemia relapse;Leukemic Cell;leukemic transformation;Malignant Neoplasms;MEK inhibition;MEKs;Methodology;MLL gene;Modeling;Molecular;mouse model;Mus;mutant;Mutation;next generation;NF1 mutation;older adult;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;pediatric patients;permissiveness;Play;programs;Proliferating;Proteins;Ras Signaling Pathway;Refractory;Relapse;Resistance;resistance mechanism;response;retransplantation;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Somatic Mutation;synergism;System;Testing;Therapeutic;TP53 gene;transcription factor;transcriptome sequencing;Translating;Transplantation;Treatment-related toxicity;validation studies;Work

PROJECT_TITLE: Co-targeting BET Bromodomain Proteins and Aberrant Signaling in AML.

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative Maintaining health depends on the ability of the body to sense changing internal and external environments, which is accomplished by nerve cells called afferents. The gut uniquely has a class of afferents called intrinsic primary afferent neurons or IPANs that reside within the wall of the bowel and endow the gut with autonomous nervous activity. This project will determine the range of different functional IPANs and their detailed modes of activities and thereby pave the way for better diagnostic procedures and drug targets for digestive diseases.

PI_NAMEs: LINDEN, DAVID R. (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;afferent nerve;Afferent Neurons;Animal Model;Axon;Blood Vessels;Body System;Cavia;Cells;Chemical Stimulation;Chemicals;Cholecystokinin;Code;Colon;Consensus;Data;Diagnostic;Diagnostic Procedure;Digestive System Disorders;Disease;Drug Targeting;Electrophysiology (science);Endowment;Enteral;Enteric Nervous System;Environment;Epithelium;Experimental Designs;experimental study;Future;Ganglia;gastrointestinal function;Gastrointestinal Physiology;Gastrointestinal tract structure;Health;Hormonal;Human;improved;Inflammatory;Inflammatory Bowel Diseases;innovation;Interneurons;Intestines;Ion Channel;Ion Transport;jejunum;Knowledge;Mechanical Stimulation;mechanical stimulus;Mechanics;Mediating;Molecular;Morphology;motility disorder;Motor;Motor Neurons;Mucous Membrane;Mus;Muscle;Myenteric Plexus;nerve supply;Nervous System;neural;neural initiation;Neurobiology;Neuronal Plasticity;Neurons;Neuropeptides;neuroregulation;neurotransmission;Nutrient;Physiological;Physiology;Process;Publishing;receptive field;Reflex action;Reporter;Reporting;response;Role;Sensory;Series;single-cell RNA sequencing;Stimulus;Stretching;Structure;Submucosa;Testing;Therapeutic;Tissues;transcriptome;uptake;Vertebrates

PROJECT_TITLE: Neurobiology of Intrinsic Primary Afferent Neurons

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE This K23 application aims to develop and validate artificial intelligence tools to aid in determining the microbiologic etiology of infectious keratitis, which is a major cause of blindness worldwide. We intend to develop two artificial intelligence systems, one to determine the cause of infectious keratitis from clinical photographs and the other to read microbiologic smears in an automated fashion. These systems will allow more rapid initiation of directed antimicrobial therapy, particularly in medically underserved areas, and improve visual outcomes in infectious keratitis.

PI_NAMEs: REDD, TRAVIS KENNETH (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: antimicrobial;Appearance;Artificial Intelligence;artificial intelligence model;Biological;Biometry;Blindness;burden of illness;career;Cicatrix;Clinical;Clinical Data;clinical database;clinical imaging;Clinical Management;Clinical Trials;clinically significant;Collaborations;Computer Vision Systems;convolutional neural network;Cornea;Corneal Ulcer;Data;Data Collection;data infrastructure;Data Science;Databases;deep learning;design;Development;Diagnosis;Diagnostic;Discipline;Disease;Early treatment;Education;Epidemiology;Equipment;Etiology;Evaluation;experience;Expert Systems;Eye;Faculty;Foundations;Funding;Future;Goals;Healthcare;Hospitals;Human;Image;image archival system;imaging modality;impression;improved;India;Infection;interdisciplinary approach;International;Investigation;Keratitis;Knowledge;large datasets;Lead;Machine Learning;Medical;Medical Informatics;Medically Underserved Area;Mentored Clinical Scientist Development Program;Mentored Patient-Oriented Research Career Development Award;Mentors;Microbiology;Microscopic;Modeling;Movement;Multimodal Imaging;Neural Network Simulation;ocular imaging;Ophthalmology;Outcome;pathogen;Performance;Photography;Population;population based;Positioning Attribute;programs;Public Health;rapid diagnosis;recruit;Research;Retinopathy of Prematurity;routine Bacterial stain;Sampling;Scientist;Sensitivity and Specificity;skills;Specialist;Surgical Management;System;Techniques;technological innovation;Telemedicine;Time;tool;Training;training data;Ulcer;United States National Institutes of Health;Visual;whole slide imaging

PROJECT_TITLE: Applications of artificial intelligence to the diagnostic evaluation of infectious keratitis


NIH_SPENDING_CATS: Chronic Pain;Infectious Diseases;Neurosciences;Pain Research

ORG_CITY: PITTSBURGH

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative The skin is a highly innervated organ and contains numerous sensory afferent neurons that respond to a diverse array of stimuli. There are also many skin-resident immune cells that make direct contact with sensory neurons. We have previously shown that one subset of neurons that sense pain are necessary and sufficient for cutaneous innate Type-17 inflammation and host defense. We now propose to test the immunologic potential of other subsets of sensory neurons. The overall goal of this proposal is to understand the unique contribution of individual sensory neuron subsets in the modulation of skin immunity. Exploring this neuro-immune interaction will better define the cellular circuits driving inflammation and allow for the use of agonists/antagonists that target neuron subsets in order to modulate specific types of cutaneous immune responses without global immunosuppression.

PI_NAMEs: ALBERS, KATHRYN MARIE;KAPLAN, DANIEL H (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Ablation;Acute;afferent nerve;Afferent Neurons;Agonist;Allergic Disease;antagonist;Automobile Driving;Candida albicans;Cell Degranulation;Cell Physiology;Cells;Chronic;Classification;Communication;Contact hypersensitivity;Croton;Cutaneous;cutaneous sensory neurons;Data;Dendritic cell activation;Dendritic Cells;Dermal;Dermis;Development;Diphtheria Toxin;diphtheria toxin receptor;Epidermis;Event;extracellular;G-Protein-Coupled Receptors;gain of function;Genetic;Goals;Haptens;Host Defense;IL17 gene;Immune;immune function;Immune response;Immunity;Immunologic Tests;Immunosuppression;in vivo;Individual;Infection;Infectious Skin Diseases;Inflammation;Inflammatory;Innate Immune Response;Interruption;Irritants;Lasers;Link;loss of function;mast cell;Mechanoreceptors;Mediating;Modeling;Mus;Nerve;Neurogenic Inflammation;Neuroimmune;Neurons;Nociceptors;Oils;optogenetics;Organ;Pain;pain sensation;pathogen;Pathogenesis;Pathway interactions;Phenotype;Primates;Production;Pruritus;Resistance;response;Sensory;single-cell RNA sequencing;Skin;Somatostatin;Staphylococcus aureus;Stimulus;Testing;Th2 Cells;Touch sensation;transcriptomics;TRPV1 gene;Work

PROJECT_TITLE: Epidermal Nonpeptidergic Nerves Modulate Cutaneous Immunity

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Immunotherapy;Neurodegenerative;Neurosciences

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE The aim of this study is to understand T cells that are resident in the brain and their role in Alzheimer’s disease pathogenesis, both directly and in concert with other immune populations. There is a growing body of work indicating a role for neuroinflammation in Alzheimer’s disease, yet the impact of brain resident T cells, which can mediate potent immune activation and are well positioned to exert disease-altering effects in the brain, is unknown. Studying these cells in Alzheimer’s disease and has potential to provide insight into T cell functions in other neurological diseases and drive the development of novel immunotherapies for Alzheimer’s disease.

PI_NAMEs: ROSATO, PAMELA  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: 3xTg-AD mouse;Acceleration;Address;Affect;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease therapy;Amyloid;Antigens;Area;Atlases;Automobile Driving;Autopsy;behavior test;Brain;brain shape;brain tissue;CD8-Positive T-Lymphocytes;CD8B1 gene;cell motility;Cell Physiology;Cells;Cellular biology;Cerebrospinal Fluid;Clonal Expansion;Clonality;Cognition;Collaborations;Data;Deposition;Development;Disease;Disease Outcome;Disease Progression;experimental study;extracellular;familial Alzheimer disease;Flow Cytometry;Goals;Histologic;Human;Immune;immune activation;Immunologic Surveillance;Immunologic Techniques;Immunotherapy;Impaired cognition;improved;Individual;innovation;insight;Knock-out;Knowledge;Longitudinal Studies;Macrophage;Macrophage Activation;Mediating;Memory;Microglia;migration;Modeling;mouse model;Multiple Sclerosis;Mus;Natural Killer Cells;Nerve Degeneration;Nervous System Disorder;Neuroimmune;neuroinflammation;neuropathology;new therapeutic target;novel;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Phagocytosis;Phenotype;Play;Population;Positioning Attribute;protein aggregation;Proteins;Reaction;recruit;Reporting;Research;response;Role;single-cell RNA sequencing;Site;Synapses;T cell clonality;T cell receptor repertoire sequencing;T-Cell Activation;T-Cell Depletion;T-Lymphocyte;tau Proteins;Testing;Tissue Model;tissue resident memory T cell;Tissues;translational study

PROJECT_TITLE: The role of brain resident T cells in Alzheimer's disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: WALTHAM

ORG_DEPT: BIOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE Sensory neurons allow animals to detect and identify constantly changing environmental cues in order to make the appropriate behavioral and developmental decisions. Defects in the ability to correctly sense and process external signals lead to neurodevelopmental, behavioral, and cognitive disorders. This proposal uses the simple nervous system of the nematode C. elegans to explore how sensory neurons acquire and modify their specialized structures and functions, and how defects in these processes lead to disease.

PI_NAMEs: SENGUPTA, PIALI  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Adhesions;Afferent Neurons;analog;Animals;Architecture;Area;Award;Behavior;Behavior Disorders;Behavioral;behavioral plasticity;Caenorhabditis elegans;Cellular biology;Cilia;Code;Cognition Disorders;Collaborations;Communication;Complex;Cues;Defect;Development;Disease;environmental change;experience;functional plasticity;Funding;Gene Expression;Gene Expression Profile;Goals;Head;in vivo;Individual;innovation;insight;Lead;Modification;Morphology;National Institute of General Medical Sciences;Nematoda;Nervous System;Neurodevelopmental Disorder;Neurons;next generation;novel;Pathway interactions;Pattern;Play;Process;programs;Property;public health relevance;Recording of previous events;Regulation;Research;Resolution;response;Role;Scientist;Sense Organs;Sensory;sensory mechanism;shape analysis;Shapes;Signal Transduction;Stereotyping;Structure;synergism;Temperature;Testing;Training;Translating;Variant;Work

PROJECT_TITLE: Mechanisms of sensory neuron morphological diversification, signaling, and functional plasticity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE In this proposal, we will characterize the trajectories of outcome in early course psychotic disorders treated in coordinated specialty care programs. We will also identify clinical and biological features, and biological subtypes of psychotic disorders that may help predict outcome.

PI_NAMEs: PEARLSON, GODFREY D (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Accounting;Age Years;Biological;Biological Markers;biomarker development;biomarker identification;biotypes;Bipolar Disorder;Boston;care outcomes;care systems;Categories;Chronic;Clinic;Clinical;clinical practice;clinical predictors;Cognition;Cognitive;cognitive function;Communities;community setting;Coordinated Specialty Care;cost;Data;Data Collection;design;Diagnosis;Diagnostic;Dimensions;Disease remission;early detection biomarkers;Early Intervention;early psychosis;early satiety;Electroencephalography;Enrollment;Eye Movements;follow-up;functional decline;functional outcomes;Funding;Goals;Grant;Heterogeneity;Image;imaging biomarker;Impaired cognition;Impairment;improved;improved outcome;Individual;individual variation;Intervention;Measures;medical specialties;meetings;Modeling;Multivariate Analysis;Neurobiology;Neurocognition;Neurocognitive;neuroimaging;Neurosciences Research;Onset of illness;Outcome;outcome prediction;Participant;Patients;pharmacologic;Phenotype;phenotypic biomarker;Population;Population Characteristics;prediction algorithm;Predictive Value;Procedures;prognostic value;programs;Psychoses;psychosocial;psychotic;Psychotic Disorders;Recovery;recruit;Resources;response;Sampling;Schizoaffective Disorders;Schizophrenia;Schizophreniform Disorder;Services;Site;Stimulus;Structure;Subgroup;Substance abuse problem;success;Testing;Therapeutic Intervention;therapy resistant;Time;treatment adherence;treatment planning;treatment program;Variant

PROJECT_TITLE: 3/5 Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

PHR: PUBLIC HEALTH RELEVANCE: Through the attribution of excessive motivational value, cues in the environment can gain inordinate control over behavior and result in unwanted outcomes, such as relapse in individuals with addiction. Using an animal model, we are able to elucidate the neural mechanisms by which such cues are transformed into powerful motivators of behavior. The proposed work aims to identify the point of intersection by which stress- and reward-circuits act to potentiate the value of environmental stimuli, in hopes of identifying potential targets for the treatment of cue- driven disorders such as addiction and post-traumatic stress disorder.

PI_NAMEs: LOPEZ, SOFIA A (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: addiction;Animal Model;Association Learning;Behavior;Behavioral;behavioral response;biological adaptation to stress;Brain;Conditioned Reflex;Corticosterone;Cues;Disease;Dopamine;drug seeking behavior;Endocrine;Environment;experience;Exposure to;Food;Genetic;Goals;Growth;Incentives;Individual;Individual Differences;individual variation;Knowledge;Learning;maladaptive behavior;Mediating;Mediator;motivated behavior;Motivation;neurobiological mechanism;neurochemistry;neuromechanism;Outcome;Persons;Pharmaceutical Preparations;pharmacologic;Post-Traumatic Stress Disorders;Predictive Value;Predisposition;Process;Psychopathology;public health relevance;Rattus;Relapse;response;Rewards;Stimulus;Stress;System;Training;Work

PROJECT_TITLE: Neurobiological mechanisms underlying persistent effects of stress on drug-seeking behaviors


ORG_CITY: NASHVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: This unique training program in the molecular basis of infectious diseases offered by Meharry and Vanderbilt faculty will train talented African Americans and other URMs in infectious diseases and will foster their career development consistent with the NIAID mission. The program will train a new generation of infectious disease minority scientists who will address the national ethnic under-representation in biomedical research.

PI_NAMEs: CHAUDHURI, MINU  (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Molecular Microbial Pathogenesis Training Program

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Patient Safety;Prevention;Social Determinants of Health

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE The risk-reduction strategy that a patient engages in for the primary prevention of cardiovascular disease should be a shared-decision between the patient and their clinician. However, the uptake of shared- decision making (SDM) remains low, especially among those with low health literacy. This study seeks to address that gap by implementing an evidence-based intervention to improve the SDM behavior of patients with low health literacy.

PI_NAMEs: SANDERS, MECHELLE RENEE (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Address;American;Applications Grants;Award;Back;Behavior;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;career;career development;Clinical Trials;Code;Communication;Communities;Data;design;Development Plans;Disease;Educational process of instructing;Equity;Ethnic Origin;Evidence based intervention;experience;feasibility testing;field study;Foundations;Geography;Goals;Grant;Health;health care disparity;health literacy;Health Policy;Health Services;implementation research;implementation science;improved;International;Intervention;K-Series Research Career Programs;Knowledge;Knowledge acquisition;literacy;low health literacy;Measurement;Medical;Medical Care Team;medication compliance;Mentors;Mentorship;Methods;Motivation;motivational enhancement therapy;National Heart, Lung, and Blood Institute;novel;Office Visits;Outcome;Patient Education;patient engagement;Patient-Centered Care;patient-clinician communication;Patient-Focused Outcomes;patient-level barriers;Patients;peer;peer coaching;Pharmaceutical Preparations;pilot test;Population;prevent;preventive intervention;Primary Care;Primary Prevention;Process;Publications;randomized trial;Recommendation;Research;Research Personnel;Research Project Grants;Research Training;Resources;response;Risk Reduction;Role;satisfaction;Science;Self Efficacy;Shame;shared decision making;skills;social stigma;socioeconomics;Testing;Thinking;tool;Training;uptake

PROJECT_TITLE: Re-thinking the role of Peers And Training Patients [RePeAT]


NIH_SPENDING_CATS: Pediatric;Prevention

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: The proposed program is relevant to public health because training in pediatric clinical pharmacology is key to studying therapies for children and increasing the number of medications that are available for children. Fellows in this training program entitled “Academic Training in Therapeutic Advancement for Child Health” will receive state-of-the-art training in a strong mentorship environment in a broad range of important topics that are central to pediatric clinical pharmacology. Thus, the proposed training program is in line with NICHD's Strategic Plan as this program will train clinician-scientists the skills needed to excel within the field of pediatric clinical pharmacology and thus “enhance the lives of children and adolescents”.

PI_NAMEs: NIZET, VICTOR ;TREMOULET, ADRIANA H (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TITLE: Academic Training in Therapeutic Advancement for Child Health (ATTACH)


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE: OVERALL The Goizueta ADRC at Emory continues to grow dramatically over each 5-year cycle and is submitting this application to seek funding for years 16-20 of our center. The ADRC contributes to the NIH/NIA-funded network and plays a critical role in the coordinated response to the growing public health threat from Alzheimer’s disease (AD). Emory’s participation in the network fosters research to understand the causes, and investigate novel targets and interventions that could lead to more effective treatments and prevention, and improve the treatment of affected individuals with AD and related dementias and the well-being of their family caregivers.

PI_NAMEs: LEVEY, ALLAN I (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Academic Medical Centers;Acceleration;Action Research;Address;Advocate;Affect;African American;African American population;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Autopsy;Awareness;base;Biological Markers;Biological Specimen Banks;Blood;Brain;Brain imaging;built environment;burden of illness;caregiving;caregiving research;Caring;Clinic;Clinical;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Support Unit;cohort;Collaborations;Communities;community partnership;Data;data management;Data Scientist;Dedications;dementia burden;design;Development;Disease;Disparity;diversity and inclusion;DNA;Early identification;Education;education research;effective therapy;empowerment;ethnoracial;Faculty;faculty mentor;Family Caregiver;Fostering;Foundations;Funding;Genetic;Goals;Grant;Health Professional;healthy aging;Heterogeneity;Image;improved;Individual;Individual Differences;innovation;Institution;Intervention;Leadership;Link;Memory;memory care;minority engagement;multidisciplinary;neuropathology;next generation;novel;Outcome;outreach;Participant;Pathogenicity;Personal Satisfaction;Pilot Projects;Plasma;Play;Prevention;programs;Proteins;Proteomics;Public Health;Publications;Race;Recommendation;recruit;Research;Research Activity;Research Personnel;research study;Research Support;Resources;response;Risk;Risk Factors;Role;Sampling;Scientist;Special Population;Specimen;Spinal Cord;success;supportive environment;symposium;Teacher Professional Development;therapeutic target;Training;training opportunity;Translating;Translational Research;Translations;Underrepresented Minority;United States National Institutes of Health;Universities;Variant;Work

PROJECT_TITLE: Emory Alzheimer's Disease Research Center


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Diabetes;Nutrition;Obesity;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: MEMPHIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Weight loss is very important for overweight or obese patients with type 2 diabetes for reducing medication use and improving glucose control and other cardiovascular risk factors. However, weight loss has been associated with increased bone loss and fracture risk among these patients. The proposed study will significantly contribute to a better understanding of the biological mechanisms linking weight loss and increased risk for fracture which will help develop novel methods to protect bone and reduce fracture risk during the weight management of overweight and obese patients with type 2 diabetes.

PI_NAMEs: JOHNSON, KAREN C;ZHAO, QI  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Biological;biomarker discovery;blood glucose regulation;Blood specimen;Body Weight decreased;bone;Bone Density;bone health;bone imaging;bone loss;bone metabolism;bone preservation;bone quality;bone turnover;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Chemical Structure;comparison group;Control Groups;design;Diabetes Mellitus;disability;Disease;Dual-Energy X-Ray Absorptiometry;Education;Elderly;Etiology;Fasting;follow-up;Fracture;fracture risk;frailty;glycemic control;Goals;group intervention;Health;Health Expenditures;Hip Fractures;Hip region structure;Image;improved;Incidence;Individual;insight;Intervention;lifestyle intervention;Link;liquid chromatography mass spectrometry;Measurement;Measures;Mediating;Mediation;Mediator;metabolomics;Methods;Molecular Target;Molecular Weight;Morbidity - disease rate;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;obese patients;Obesity;osteoporosis with pathological fracture;Outcome;Overweight;Participant;Patients;Pattern;Pelvis;Pharmaceutical Preparations;Plasma;prevent;Prevention strategy;Quality of life;Randomized;randomized, clinical trials;Recommendation;Risk;risk prediction;Scanning;Science;secondary outcome;Serum;Shoulder Fractures;skeletal;Subgroup;Trabecular Bone Score;Upper arm;Upper Extremity Fracture;Validation;Visit;Weight Gain;weight loss intervention;Weight maintenance regimen

PROJECT_TITLE: Intensive Lifestyle Intervention, Metabolomics, and Risk of Frailty Fracture in Overweight or Obese Patients with Type 2 Diabetes

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

PHR: Per RFA-AG-20-004 Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.

PROJECT_TERMS: Achievement;Address;Administrator;Affect;African American population;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Welfare;Area;Award;Biological Markers;career networking;Clinical;clinical care;Clinical Research;Collaborations;Communication;Communities;community engagement;dementia burden;Development;Disparity;Early identification;Early Intervention;Education;education research;Ensure;Environment;Ethics;Exposure to;Fertilization;Fostering;Funding;Future;Goals;Growth;high standard;human subject;improved;Individual;Infrastructure;innovation;Institution;International;Intervention;knowledge network;Leadership;meetings;minority engagement;multidisciplinary;Neurosciences;open data;Pathogenicity;Pilot Projects;Policies;programs;Research;Research Activity;Research Personnel;Resources;System;Talents;Training;Translations;Universities;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lewy Body Dementia;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: Per RFA-AG-20-004  Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is  required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive  an error if omitted in other components.

PI_NAMEs: LAH, JAMES J (contact)

PROJECT_TERMS: Acceleration;African American;Alzheimer's Disease;Area;Automobile Driving;Biological Markers;Biology;biomarker discovery;Blood Vessels;Cardiovascular Physiology;Cardiovascular system;Caucasians;Clinical;clinical center;clinical phenotype;Clinical Research;Clinical Trials Unit;cohort;Collection;Data Analyses;data management;data sharing;Dementia;Dementia with Lewy Bodies;Development;diagnostic tool;Disease;Enrollment;Etiology;follow-up;Funding;Goals;improved;Individual;Institution;International;Lead;Lewy Body Disease;Lewy body pathology;Link;Longitudinal cohort;Measures;Medicine;minority engagement;Molecular;Movement Disorders;neuropathology;new therapeutic target;novel marker;operation;outreach;Parkinson Disease;Parkinson's Dementia;Participant;participant enrollment;Phenotype;Play;Positioning Attribute;Procedures;Process;racial disparity;Recommendation;recruit;Research;Research Activity;research and development;Research Project Grants;research study;Role;sample collection;success;symposium;System;Training Activity;United States National Institutes of Health;Validation;Vascular Cognitive Impairment;vascular factor;Work


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Crohn's Disease;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Prevention

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: SINAI HEALTH SYSTEM

ORG_STATE: ON

ORG_ZIPCODE: M5G 1X5

PHR: Project Narrative The University of Toronto Genetic Research Center, working within the NIDDK IBD Genetics Consortium, is proposing a series of studies aimed at transforming the knowledge gained through genetic studies in IBD into functional biology that can impact patient care in the near term. While ultimately the goal remains to prevent IBD from occurring, these studies aim to reduce the risk of relapse in ulcerative colitis, through better understanding of the biology of persistent inflammation in contributing to relapse and colorectal cancer risk and to elucidate the immune and cellular profile of treatment refractory Crohn’s disease. Through the insights gained, we hope to improve the quality of life of individuals affected by IBD in the near future while continuing our long-term goals to prevent IBD from arising in the first place.

PI_NAMEs: SILVERBERG, MARK S. (contact)

PROJECT_TERMS: Acute;Affect;Anti-Inflammatory Agents;Anus;Architecture;Back;Biological;Biological Response Modifier Therapy;Biology;Cells;Characteristics;chronic inflammatory disease;Cities;Clinical;Clinical assessments;clinical care;clinical risk;Colectomy;colitis-associated neoplasia;Colonic inflammation;Colorectal Cancer;colorectal cancer risk;Colorectal Neoplasms;Communities;Complement;Complication;Crohn's disease;Cytometry;Data;Development;Disease;disease phenotype;Dysplasia;effective therapy;Etiology;Event;Flare;Functional disorder;Future;genetic architecture;Genetic Diseases;Genetic Research;Genetic study;genetic variant;Genetic Variation;genome wide association study;genome-wide analysis;genomic profiles;Genomics;Goals;Histologic;Hospitalization;Hospitals;Image;Immune;Immunologic Factors;Immunologics;improved;improved outcome;Individual;Inflammation;Inflammatory Bowel Diseases;Infrastructure;insight;Intestines;Knowledge;Laboratories;Lead;microbial;microbiome analysis;microbiome composition;Microscopic;Minority Groups;Molecular;Monitor;mortality;multiple omics;National Institute of Diabetes and Digestive and Kidney Diseases;Neoplasms;North America;Outcome;Patient Care;patient population;patient response;Patients;Pattern;Phenotype;Population;Positioning Attribute;Predisposition;Prevalence;prevent;prospective;Quality of life;Recurrence;Recurrent disease;Refractory;Registries;Relapse;relapse risk;Research;Research Institute;Resources;Retrospective cohort;Risk Factors;risk mitigation;Risk Reduction;Sampling;Series;single-cell RNA sequencing;Susceptibility Gene;synergism;Techniques;Technology;Therapeutic Intervention;Time;Tissues;tool;transcriptomics;Translations;Ulcerative Colitis;Underrepresented Populations;Universities;Variant;Work

PROJECT_TITLE: Genomic and Immunologic Characterization of Inflammatory Bowel Disease and its Phenotypes


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: ALONSO, ALVARO  (contact)

PROJECT_TERMS: Acceleration;Address;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;analytical method;Autopsy;Bioinformatics;Biological Markers;Biometry;Blood Vessels;Clinical;Clinical Data;Collaborations;computerized tools;Data;Data Collection;data infrastructure;data integration;data integrity;data management;Data Mart;data repository;Data Storage and Retrieval;Databases;design;Development;Disease Progression;DNA Methylation;Early Diagnosis;Education;education research;Electronics;Ensure;Epidemiology;epigenomics;Equipment and supply inventories;Etiology;Faculty;Funding;gene discovery;Gene Expression;Genetic;Genomics;Goals;Grant;Grant Review;Human Resources;Image;improved;Information Systems;Infrastructure;innovation;International;Investments;Laboratories;large datasets;Link;Management Information Systems;Medicine;Methodology;Methods;methylation biomarker;Mission;Molecular;Monitor;multimodality;Multiomic Data;neuroimaging;neuropathology;novel;novel marker;Online Systems;Onset of illness;Peer Review;Prevention;Proteomics;Public Health Schools;Publications;Reporting;repository;Research;Research Design;Research Personnel;Resource Sharing;Sampling;Specimen;Statistical Methods;statistics;System;Systems Biology;Tissues;transmission process;Universities;web platform;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: GLASS, JONATHAN DAVID (contact)

PROJECT_TERMS: Address;African American population;age related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Animal Disease Models;Attention;Autopsy;Biological Markers;Board Certification;Brain;Brain Diseases;career;Centers of Research Excellence;Classification;Clinical;clinical phenotype;Collaborations;Collection;Consult;Consultations;Country;Data;data standards;Dementia;Dementia with Lewy Bodies;design;Development;Diagnosis;Diagnostic;Disease;education research;Elderly;experience;Experimental Designs;Fellowship;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Funding;Genetic;Glass;Goals;Guidelines;Harvest;Human;Human Resources;human tissue;innovation;interest;International;Laboratories;Leadership;Link;member;Methods;Microscope;Minority Outreach Program;Mission;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neurology;neuropathology;next generation;novel;Pathogenicity;Pathologic;Pathologist;Pathology;Patients;Peer Review;preservation;Price;programs;protein TDP-43;proteogenomics;Proteomics;Publications;recruit;Research;Research Activity;Research Personnel;Research Project Grants;research study;Resources;Services;Spinal Cord;Structure;Students;System;Techniques;therapy development;Tissue Banks;tissue preparation;tissue resource;Tissue Sample;Tissues;Training;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Caregiving Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: PARKER, MONICA WILLIS (contact)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: SEYFRIED, NICHOLAS THOMAS (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease risk;Alzheimer's disease therapy;Alzheimer’s disease biomarker;Amyloid beta-42;Area;Biological Assay;Biological Markers;Biological Specimen Banks;biomarker discovery;biomarker identification;Brain;Brain imaging;brain magnetic resonance imaging;candidate marker;Chronic Disease;Clinical;Clinical Trials;cohort;Collection;Communities;Complement;complex data;Data;Data Analyses;Data Mart;Data Set;Databases;Dementia;Diagnosis;Disease;DNA Resequencing;Elements;Eligibility Determination;Ensure;Environment;Etiology;Foundations;Funding;Genes;Genetic;genetic analysis;genetic information;genetic profiling;genomic data;Genotype;genotypic sex;Goals;Human;Individual;Inherited;innovation;Intervention;Learning;Magnetic Resonance Imaging;Methods;mild cognitive impairment;mutation carrier;neuroimaging;neuropathology;novel marker;Participant;Pathology;Population;Positron-Emission Tomography;Procedures;Process;prognostic;Proteomics;Protocols documentation;Quality Control;Race;recruit;repository;Research;Research Activity;Research Personnel;Research Support;response;risk variant;Sampling;serial imaging;Services;Standardization;System;Talents;tau Proteins;tau-1;Testing;tool;whole genome;Work


ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: OVERALL PROJECT NARRATIVE The NCI-designated Simmons Comprehensive Cancer Center integrates cancer research, cancer care, cancer control, community outreach, and education and training across UT Southwestern Medical Center and its health system affiliates. The overriding mission of the Center is to leverage these affiliations and the exceptional resources available to foster translational research and improve cancer outcomes in the Dallas-Fort Worth (DFW) region and the nation.

PI_NAMEs: ARTEAGA, CARLOS L (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Address;animal imaging;anti-cancer research;authority;Award;Basic Science;Biometry;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer health disparity;cancer prevention;Cancer Science;cancer therapy;Caring;Catchment Area;Chemistry;Child;Clinic;Clinical;clinical care;clinical investigation;Clinical Investigator;Clinical Sciences;Clinical Trials;Collaborations;Communities;community engagement;Community Health Education;Community Outreach;Comprehensive Cancer Center;County;Coupling;Data Science;design;Development;Diagnosis;Disparity;Education;Educational Activities;empowerment;Ensure;Extramural Activities;Fostering;Funding;Generations;Growth;Health;Health Personnel;Health system;high throughput screening;Hospitals;Improve Access;improved;Infrastructure;innovation;Institution;international center;Intervention;Investigational Therapies;Investments;Laboratories;Leadership;live cell imaging;Malignant Neoplasms;Medical center;member;Mission;Movement;multidisciplinary;National Cancer Institute;next generation;novel strategies;operation;Outcome;Outpatients;outreach;outreach program;Patient Care;Patients;Physicians;Pilot Projects;Population Heterogeneity;Population Sciences;Population Study;Positioning Attribute;Prevention;Prevention approach;Prevention education;programs;Qualifying;rapid growth;recruit;Renal Carcinoma;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Scientist;Secure;Shoulder;Strategic Planning;System;Texas;Tissues;Training and Education;training opportunity;Translating;translational impact;Translational Research;Vision

PROJECT_TITLE: UT Southwestern Medical Center Simmons Comprehensive Cancer Center

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Hearing Loss;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: ROOTSTOWN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHEAST OHIO MEDICAL UNIVERSITY

PHR: NARRATIVE Early-life stress increases the risk of long-term language deficits in children with fluctuating hearing loss from chronic ear infections. While the potential mechanisms of this interaction are unexplored, our data suggest that early life stress on its own causes auditory perceptual deficits and alters sound-evoked responses in auditory cortex, a known locus of dysfunction in early hearing loss. This project will determine whether auditory perceptual deficits induced by early life stress, on its own and in conjunction with hearing loss, are explained by changes at the level of auditory cortex, and determine whether changes to inhibitory circuits are mechanistically involved in these perceptual deficiencies.

PI_NAMEs: ROSEN, MERRI J. (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acquired Deafness;Adolescence;Adult;Affect;Agonist;Anatomy;Animal Vocalization;Animals;Area;Attention;Auditory;Auditory area;auditory pathway;Auditory Perception;auditory processing;Auditory system;Behavior assessment;Cell Density;Cells;Child;childhood hearing loss;Chronic;Cognitive;Conductive hearing loss;critical period;Data;density;design;Detection;Development;ear infection;early life stress;early onset;Elements;experience;experimental study;frontal lobe;Functional disorder;Future;gamma-Aminobutyric Acid;Gerbils;hearing impairment;hearing loss treatment;Impairment;improved;inhibitory neuron;Inhibitory Synapse;Language;Language Disorders;language processing;Learning;Link;low socioeconomic status;Measures;Modeling;Nature;Nervous System;neural;Neurons;neurophysiology;novel;Otitis Media;Perception;Physiological;Prevention;response;Risk;Sensory;Sensory impairment;Signal Transduction;sound;Speech;Stimulus;Stress;Task Performances;Testing;Training

PROJECT_TITLE: Auditory Processing Deficits in Early-Onset Conductive Hearing Loss

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Affect;African American;African American population;Ally;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Basic Science;Black race;Brain;caregiver stress;Caring;Caucasians;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Clinical;Clinical Research;Clinical Trials;cohort;Collaborations;Collection;Communities;community academic partnership;community organizations;community partners;community partnership;Continuing Education;Data;demented;Dementia;design;Disease;Education;Education and Outreach;Enrollment;ethnic minority;ethnic minority population;Faculty;Family;Fostering;Foundations;Goals;Health;Healthcare;Healthcare Activity;Healthcare Systems;healthy aging;Impaired cognition;improved;innovation;Justice;Knowledge;Latino;Leadership;Lesbian Gay Bisexual Transgender Queer;Magnetic Resonance Imaging;Maintenance;member;men;minority engagement;Minority Groups;Modeling;Nurses;outreach;outreach program;Participant;Persons;Population Heterogeneity;Prevention strategy;programs;racial difference;racial diversity;racial population;recruit;Recruitment Activity;Registries;Research;Research Personnel;Research Project Grants;retention rate;Risk;Services;social;success;System;Translational Research;Trust;Underrepresented Minority;Underrepresented Populations;Universities;Vascular Diseases;Visit;Work


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Academic Medical Centers;Administrator;Budgets;Cancer Center;Cancer Center Support Grant;Charge;Clinical Data;Clinical Protocols;Collaborations;Communication;Comprehensive Cancer Center;Data;data management;Decision Making;Dedications;Development;Documentation;Environment;Equipment;Evaluation;experience;Faculty Recruitment;faculty support;Funding;Funding Mechanisms;Goals;Grant;Human Resources;Individual;Information Systems;Information Technology;Institution;Leadership;Medical center;meetings;member;Mission;Monitor;operation;Outcomes Research;Pilot Projects;Process;programs;Progress Reports;Reporting;Research;Research Personnel;Resource Sharing;Resources;Services;Strategic Planning;technology platform;Vision

PROJECT_TITLE: Cancer Center Administration Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: WEINSHENKER, DAVID  (contact)

PROJECT_TERMS: Achievement;Address;Advisory Committees;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;American;Area;Behavioral;Biological Markers;Biomedical Engineering;career;Catalogs;Clinical;Clinical Research;Clinical Sciences;cohort;Companions;Complement;Data Science;Dementia;Diagnostic;Discipline;Education;education planning;education research;education resources;Educational Activities;Educational Curriculum;Educational workshop;Environment;Evaluation;experience;Faculty;Fostering;Funding;Future;Generations;Goals;improved;innovation;Institution;instrument;Laboratories;Leadership;meetings;Mentors;Mentorship;Methodology;Minority;minority investigator;minority trainee;Mission;Molecular;Monitor;multidisciplinary;Neurosciences;next generation;Output;Participant;Pathogenicity;Postdoctoral Fellow;Prevalence;Prevention;programs;Recording of previous events;recruit;Research;Research Activity;Research Personnel;Research Support;Research Training;Resources;Scientist;skills;Standardization;success;symposium;System;Teacher Professional Development;therapeutic target;Time;tool;Training;Training Programs;Translational Research;translational scientist;Translations;Underrepresented Minority;Universities;Work


NIH_SPENDING_CATS: Genetics

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Development of any species relies critically on spatially organized mRNAs. While mRNA typically become organized by RNA binding proteins, they can also self-organize into multi-transcript assemblies, a phenomenon observed in heathy cells across species as well as in human disease. The aim of this study is to determine the mechanism of mRNA assembly and its role in regulating post-transcriptional reactions during development.

PI_NAMEs: TRCEK, TATJANA  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Acute;Amyotrophic Lateral Sclerosis;Automobile Driving;Base Pairing;Biological Process;Cell Lineage;Cells;Cellular Morphology;Cytoplasmic Granules;Data;design;Development;Disease;Drosophila genus;Environment;Genetic;Germ;Goals;Human;human disease;imaging approach;In Vitro;in vivo;insight;Light;Membrane;Messenger RNA;Methods;Myotonic Dystrophy;Oils;Organism;particle;Pathogenesis;Phase;posttranscriptional;prevent;Process;Property;Reaction;recruit;Resolution;Ribonucleoproteins;RNA;RNA Helicase;RNA-Binding Proteins;Role;self assembly;self organization;Specific qualifier value;Spinocerebellar Ataxias;Structure;Subcellular structure;superresolution imaging;Transcript;Translations;Water

PROJECT_TITLE: mRNA assembly in Drosophila germ granules

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


PI_NAMEs: SHAY, JERRY WILLIAM (contact)

PROJECT_TERMS: Advisory Committees;anti-cancer research;Award;Basic Science;Budgets;Cancer Biology;cancer education;cancer health disparity;cancer research center director;career;career development;Clinical;clinical investigation;Clinical Investigator;Clinical Oncology;Clinical Sciences;Collaborations;Communication;Community Health Education;Complement;Comprehensive Cancer Center;Dedications;Development;Doctor of Philosophy;Education;education research;experience;Faculty;Fellowship;Foundations;Funding;Funding Opportunities;Future;graduate student;Grant;high school;High School Student;Individual;Infrastructure;innovation;Institution;Investigation;Investments;K-Series Research Career Programs;Laboratories;Leadership;Malignant Neoplasms;Medical center;member;Mentored Clinical Scientist Development Program;Mentors;Mission;Peer Review;Play;population based;Population Sciences;Postdoctoral Fellow;Program Development;programs;Public Health Schools;recruit;Research;Research Personnel;Resources;Role;Science;success;symposium;teacher;Texas;Training;Training Activity;Training and Education;Training and Infrastructure;training opportunity;Training Programs;Training Support;Translational Research;undergraduate student;underrepresented minority student;United States National Institutes of Health;Universities

PROJECT_TITLE: Cancer Research Training and Education Coordination