NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Mesenchymal stromal cells are promising therapeutic cells that may treat many challenging diseases, yet very difficult to produce as they often rapidly age and lose their therapeutic functions during expansion. This proposal will develop an AI-based method for designing the drugs that can delay the MSC aging process by controlling the biochemical signaling of the MSCs. Upon completion, this proposal will enable us to produce highly therapeutic potent MSCs in a reproducible manner and advance fundamental understandings in aging signaling of MSCs.

PI_NAMEs: LIN, NEIL  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Age;Aging;aging process;Algorithms;artificial intelligence method;artificial intelligence model;Artificial Intelligence platform;Biochemical;Black Box;Cell Aging;Cell Therapy;Cells;cellular engineering;Characteristics;Clinical;DDR2 gene;deep learning;deep learning model;design;Disease;Drug Design;EGF gene;Engineering;Ensure;Fibroblast Growth Factor;FRAP1 gene;Gene Expression;Genetic Transcription;Goals;improved;In Vitro;in vivo;innovation;Knowledge;mesenchymal stromal cell;Metabolic;Morphology;Outcome;Phenotype;Process;Proliferating;Rejuvenation;Reproducibility;Research;response;senescence;Signal Pathway;Signal Transduction;Technology;Therapeutic;tool;Training;training data

PROJECT_TITLE: AI-informed Signaling Factor Design for in vitro Rejuvenating Mesenchymal Stromal Cells

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Trainees receive an MD degree and a PhD in a medically-relevant field of research. Program graduates are optimally prepared to establish research-based careers in which the goal is to improve the public's health.

PI_NAMEs: COLLINS, KATHLEEN L. (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TITLE: Michigan Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Malaria is one of the major global health problems afflicting about 229 million people and causing over 400,000 deaths annually. Because of the emergence of drug resistance parasites, current therapies for malaria are rapidly losing their efficacy. The proposed research seeks to identify novel antimalarial lead compounds targeting parasite protein kinases effective against multidrug resistant malaria with therapeutic and prophylactic properties, thus contributing to the global malaria elimination campaign.

PI_NAMEs: CHAKRABARTI, DEBOPAM  (contact);GRAY, NATHANAEL SCHIANDER;WINZELER, ELIZABETH A

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Address;Affect;Africa;Aminopyridines;analog;Animal Model;Anti-Infective Agents;Anti-malarials;Appearance;Artemisinins;asexual;Binding Sites;Biochemical;Biological;Biological Assay;Biology;Blood;California;cancer therapy;Cellular biology;Cessation of life;Chemicals;Child;Collaborations;Collection;Combined Modality Therapy;Copy Number Polymorphism;Cyclic AMP-Dependent Protein Kinases;design;Development;Dose;drug development;Drug Industry;Drug resistance;efficacy evaluation;Erythrocytes;Evaluation;Evolution;Exhibits;Falciparum Malaria;FDA approved;Florida;genome sequencing;global health;Goals;human disease;humanized mouse;Hydrophobicity;improved;In Vitro;in vivo;Infection;inhibitor;inhibitor therapy;Interdisciplinary Study;kinase inhibitor;knock-down;Knowledge;Laboratories;Lead;Lipids;Liver;Malaria;Methods;Modeling;Molecular;Molecular Conformation;Molecular Target;mouse model;Multi-Drug Resistance;Mus;nanomolar;next generation;novel;Oncogenic;optimism;Parasite resistance;Parasites;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;pharmacophore;Phenotype;phosphoproteomics;Phosphorylation;Phosphotransferases;Plasmodium;Plasmodium falciparum;Plasmodium falciparum genome;Plasmodium vivax;Population;Predisposition;Property;prophylactic;Prophylactic treatment;Protein Kinase;protein kinase inhibitor;Proteins;pyridine;Relapse;Reporting;Research;Resistance;Resistance profile;resistant strain;Resources;Route;scaffold;screening;Signal Pathway;small molecule therapeutics;Source;Southeastern Asia;targeted treatment;Testing;Therapeutic;Thiophenes;Universities;Validation;whole genome

PROJECT_TITLE: Plasmodium Protein Kinase Focused Antimalarials Discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Summary  Reducing new HIV and STI infections among South African adolescent girls and young women (AGYW) is global public health priority,1 as South African AGYW acquire HIV at twice the rate of and seroconvert on average 5 – 7 years earlier than male peers.2 Female caregivers are an untapped resource in the HIV prevention toolbox3, 4 and offer a novel opportunity to strengthen AGYW prevention efforts, particularly for uptake of new biomedical technologies like PrEP and HIV testing and counseling. This study will evaluate and compare IMARA-South Africa, a locally adapted version of IMARA, to a health promotion control program in a 2-arm randomized controlled trial with 645 15-19 year-old AGYW and their female caregiver.

PI_NAMEs: BEKKER, LINDA-GAIL GAIL;DONENBERG, GERI R (contact)

PROGRAM_OFFICER_NAME: LEE, SONIA S

PROJECT_TERMS: 18 year old;19 year old;2 arm randomized control trial;Acquired Immunodeficiency Syndrome;Adolescent;Adopted;AIDS prevention;Area;Behavior;behavior change;Biomedical Technology;Black race;Caregivers;Caring;cost;cost effectiveness;Counseling;Data;Educational Curriculum;effectiveness evaluation;Epidemic;Epidemiology;experience;Family;Female;Female Adolescents;follow-up;Friends;Generations;girls;Health Promotion;high risk sexual behavior;HIV;HIV disparities;HIV risk;HIV/STD;Human immunodeficiency virus test;Incidence;Individual;Inequity;Infection;innovation;Intervention;male;Mediator;metropolitan;multidisciplinary;novel;peer;pre-exposure prophylaxis;prevent;Prevention program;Primary Prevention;programs;public health priorities;Resources;Risk;Risk Behaviors;role model;seroconversion;Services;sexual risk taking;Shapes;social;South Africa;South African;stem;Testing;Time;transmission process;uptake;women's prevention;young woman;Youth

PROJECT_TITLE: Multilevel Comprehensive HIV Prevention for South African Adolescent Girls and Young Women


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Narrative: We develop synthetic genetic controller circuits for autonomous transcription factor-directed differentiation. The genetic circuits sense the state of the cell to express programming transcription factors at the optimal levels, robustly to epigenetic silencing. We showcase this technology on the problem of differentiating hiPSCs to the hemogenic endothelium, which is a critical intermediate to generate hematopoietic stem and progenitor cells.

PI_NAMEs: DEL VECCHIO, DOMITILLA  (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Adult;Affect;Affinity;Architecture;Blood Cells;Brachyury protein;Catalytic Domain;Cell Differentiation process;Cell Line;Cell Therapy;cell type;Cells;cellular engineering;chimeric antigen receptor T cells;chromatin modification;Clinical;clinical translation;cost effectiveness;Coupled;Cytotoxic T-Lymphocytes;Data;design;Development;Developmental Process;differentiation in vitro;differentiation protocol;directed differentiation;DNA Binding Domain;dosage;Endothelial Cells;Engineered Gene;Engineering;Ensure;Epigenetic Process;epigenetic silencing;Exhibits;experimental study;Feedback;Fluorescence;Gene Expression;Gene Silencing;gene therapy;Generations;Genes;Genetic;Goals;Hematopoietic;Hematopoietic stem cells;hemogenic endothelium;human induced pluripotent stem cells;innovation;Link;LMO2 gene;Lymphoid;Lymphoid Cell;Manuals;mathematical model;Mediating;Mesoderm;Methods;Monitor;morphogens;Myelogenous;Outcome;Output;overexpression;prevent;Process;Production;programs;promoter;Protocols documentation;recruit;Regulation;Reporter;Resistance;response;RNA;Safety;sensor;small molecule;synthetic biology;System;T-Lymphocyte;Technology;Testing;Therapeutic;Time;tool;Transcript;transcription factor;Transcriptional Regulation;Transgenes;Vascular Endothelial Cell;Work

PROJECT_TITLE: Synthetic Genetic Controller Circuits for Transcription Factor-Directed Differentiation

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Pediatric

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Maternal immune activation (MIA) is a primer for long-term neuropsychiatric consequences in offspring, although the exact mechanisms underlying offspring neurodevelopmental defects resulting from these maternal immune insults are unknown. Here, we provide evidence that MIA-induced changes in the developing offspring’s extracellular chondroitin and dermatan sulfate glycosaminoglycan (CS/DS-GAG) sulfation patterning, which are key regulator of axonal guidance and synaptogenesis during neurodevelopment, may result in developmental defects that predispose the offspring to mental health disorders in the adult, and studies outlined within this proposal aim to further investigate this possibility.

PI_NAMEs: ALONGE, KIMBERLY MICHELE (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Acceleration;Adolescent;Adult;Affect;American;Anabolism;ATP phosphohydrolase;autism spectrum disorder;Axon;axon growth;axon guidance;axonal pathfinding;Behavior;Behavioral;Binding;Binding Proteins;Biochemical;Biological;Biology;biophysical properties;Bipolar Disorder;Brain;brain volume;cell motility;Chemicals;Childhood;Chondroitin Sulfate A;Chondroitin Sulfate C;Chondroitin Sulfates;Clinical Research;Code;Coupled;critical period;Cues;cytokine;Data;Defect;Dermatan Sulfate;dermatan sulfate chondroitin sulfate;Detection;Development;Disease;early childhood;Elements;Engineering;epidemiology study;Event;Exhibits;Exposure to;extracellular;Extracellular Matrix;fetal;Fiber;GAG Gene;Gene Expression;genetic signature;Growth Factor;High Fat Diet;Hippocampus;Hypersensitivity;Immune;immune activation;Impairment;Interneurons;Intervention;Isomerism;Lactation;laser capture microdissection;Length;Life;Link;Mass Spectrum Analysis;mechanotransduction;Mediating;Mediator;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;Microglia;migration;Modeling;mother nutrition;Motor;multidisciplinary;Mus;nanopore;neurodevelopment;Neurodevelopmental Disorder;Neuroimmune;neuropathology;neuropsychiatric disorder;neuropsychiatry;nonhuman primate;novel;offspring;Patients;Pattern;Polymers;Polysaccharides;polysulfated glycosaminoglycan;postnatal;postnatal development;preclinical study;Pregnancy;prenatal;Prevalence;prevent;Prevention;Process;Proteins;regional difference;Regulation;Reporting;Resolution;response;Risk;Rodent;Schizophrenia;sensor;single molecule;spatiotemporal;Stimulus;Structure;Sulfate;synaptogenesis;Techniques;Technology;theories;translational potential;Zika Virus

PROJECT_TITLE: Maternal immune activation remodeling of offspring glycosaminoglycan sulfation patterns during neurodevelopment


NIH_SPENDING_CATS: Clinical Research;Emergency Care;Genetics;Health Services;Human Genome;Patient Safety;Precision Medicine

ORG_CITY: DENVER

ORG_NAME: DENVER HEALTH AND HOSPITAL AUTHORITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE The PEGASUS-2 research program applies precision medicine discovery to improve the effectiveness and safety of drugs administered for common acute conditions. This integrated systems biology approach utilizes multi-omic methods to untangle the biology of drug effectiveness and safety in acute care settings decreasing health care costs and improving patient care.

PI_NAMEs: MONTE, ANDREW ALBERT (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;analytical method;Award;biobank;Biological Specimen Banks;Biology;Cardiovascular Diseases;Clinical;Data;data integration;Drug Targeting;Effectiveness;Electronic Health Record;Emergency Medicine;Emergency Situation;epigenomics;Funding;Future;Genetic;Genetic Polymorphism;Health Care Costs;improved;Link;Machine Learning;medication safety;Metabolic;metabolomics;Methods;Modeling;multiple omics;Nausea;Pain;Patient Care;Patients;Pharmaceutical Preparations;Pharmacogenomics;Pharmacotherapy;phenotypic data;polygenic risk score;precision medicine;programs;prospective test;Proteomics;public health relevance;Research;Research Personnel;Safety;Site;success;Systems Biology;Therapeutic

PROJECT_TITLE: Personalizing EmerGency/Acute therapeuticS Utilizing Systems biology (PEGASUS-2)


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PI_NAMEs: HENNINGFIELD, MARY ;LIU, YAO ;SCHRAGER, SARINA B (contact);WARD, EARLISE C

PROGRAM_OFFICER_NAME: QASHU, FELICIA M

PROJECT_TERMS: Acceleration;Address;Clinic;Clinical Research;Clinical Trials;Collaborations;Communities;community advisory board;community engagement;Community Health;design;Education;Ensure;Evidence based practice;experience;Family Practice;Federally Qualified Health Center;Feedback;Funding;Health;health care service organization;Health Promotion;Human Resources;implementation science;improved;Individual;Infrastructure;interest;Leadership;Learning;learning network;medical schools;meetings;member;Participant;Patient Participation;Patient-Focused Outcomes;practice-based research network;pragmatic trial;Primary Care;primary care clinic;primary care practice;primary care setting;Process;Public Health;recruit;Recruitment Activity;Research;Research Activity;Research Infrastructure;Research Support;Resources;Rural;rural Americans;Rural Community;rural health clinic;Testing;Translational Research;United States National Institutes of Health;Universities;Wisconsin;Work

PROJECT_TITLE: The Wisconsin Research and Education Network (WREN): Expanding Research Capacity in Rural Primary Care Clinics


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: CORAL GABLES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: NARRATIVE This proposal for a Research Supplement to Promote Diversity (parent MPI grant, R01 DC018733, “Functions of gustatory afferent neuron types”, co-PI's S Roper and N Chaudhari) will fund the training of an enthusiastic, talented young Hispanic female neuroscience graduate, Ms. Isabella Fleites. Isabella is an honors graduate in Behavioral and Cognitive Neuroscience at the University of Florida, a researcher in the McKnight Brain Institute at the University of Florida, and an award-winning participant in the nationally competitive SURF (Summer Undergraduate Research Fellowship) program at the University of Miami. SURF aims, in large part, to promote diversity in the scientific community. Isabella is keen to continue her training in sensory neuroscience and work on questions of sensory coding in my laboratory. She will be mentored by several collaborators as well as myself and will conduct an independent study closely related to ongoing studies in the parent grant. Isabella will present her findings at local and national meetings and will aim for at least one publication to strengthen her ability to compete for enrollment in a ranking national PhD program en route for her goal of a career in scientific research.

PI_NAMEs: CHAUDHARI, NIRUPA ;ROPER, STEPHEN D. (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Afferent Neurons;Award;Behavioral;Brain;career;Code;cognitive neuroscience;Communication;Communities;complex data;Computer software;Computers;Data Analyses;Doctor of Philosophy;Educational workshop;Enrollment;experience;Experimental Designs;Fellowship;Florida;Foundations;Funding;Future;Genetic Engineering;Goals;Grant;Health;Hispanic Women;Image;in vivo;Institution;Joints;Knowledge;Laboratories;Laboratory Research;Learning;meetings;member;Mentors;Molecular;Mus;Neurobiology;Neurons;Neurosciences;Neurosciences Research;Operative Surgical Procedures;parent grant;Parents;Participant;peer;Periodicals;Problem Solving;programs;Publications;Receptor Cell;Research;Research Personnel;Research Training;Route;Science;Scientist;Sensory;Sensory Ganglia;sensory neuroscience;skills;Solid;statistics;success;symposium;Talents;Technical Expertise;Training;Transgenic Organisms;undergraduate research;Universities;Work

PROJECT_TITLE: Research Supplement to Promote Diversity in Health-Related Research-Functions of gustatory afferent neuron types.


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PI_NAMEs: BUKUSI, ELIZABETH ANNE;COHEN, CRAIG R (contact);NDUNYU, LOUISA ;WEISER, SHERI DAWN

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: adverse pregnancy outcome;Agriculture;California;cervical cancer prevention;Clinical Research;Collaborations;Community Developments;design;Development;Doctor of Philosophy;doctoral student;Female Adolescents;food security;Funding;global health;Health;health training;HIV;Hybrids;Hygiene;improved;interest;Intervention;Kenya;life span;Location;Measures;Medical;Medical Research;medical schools;Medicine;Mentors;Mentorship;next generation;Persons;Postdoctoral Fellow;Prevention;programs;Public Health Schools;recruit;Research;Research Institute;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;Risk Reduction;Schools;Scientist;Secondary Schools;Sexually Transmitted Diseases;social stigma;Students;Sustainable Development;symposium;Testing;Training;Training Programs;Training Support;Universities;virtual;Widow;Woman;women's outcomes;women's prevention

PROJECT_TITLE: Sustainable Development for Improved HIV Health and Prevention in Kenya (SD4H-Kenya)


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative The Emory VTP-T32 addresses the urgent need for training the next generation of vaccinologists. Vaccines have dramatically reduced the burden of infectious diseases, shown great potential for preventing and controlling conditions, and often are highly cost-effective. However, to achieve the full potential of vaccines and address difficulties that have hindered progress, a new generation of well-prepared scientists continues to be needed.

PI_NAMEs: AMARA, RAMA RAO ;LOPMAN, BENJAMIN A;ROUPHAEL, NADINE GEORGES (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Generations;Training

PROJECT_TITLE: Training a new generation of vaccinologists

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE The objective of this training program is to increase the number of Tanzania physician scientists with rigorous training in patient-oriented HIV clinical investigation. Mwanza Intervention Trials Unit (MITU) and Weill Bugando will establish courses in clinical investigation, advanced biostatistics, and epidemiology to be offered in Mwanza and 15 long-term trainees will conduct mentored research in one of the following HIV research priority areas: HIV prevention and vaccine research, implementation of HIV testing and treatment, women's health, and management of HIV related opportunistic infections and cardiovascular disease. The goal is to establish MITU/Weill Bugando as a training hub for HIV clinical investigation in East Africa.

PI_NAMEs: FITZGERALD, DANIEL W (contact);KAPIGA, SAIDI

PROJECT_TERMS: Africa;AIDS prevention;Appointment;Area;Behavioral Research;Cardiovascular Diseases;Caring;clinical investigation;Clinical Investigator;Clinical Trials;co-infection;Collaborations;Disease;Doctor of Pharmacy;Doctor of Philosophy;epidemiology study;Funding;Goals;HIV;HIV Infections;Human immunodeficiency virus test;Hygiene;improved;individual patient;Institution;institutional capacity;Intervention Studies;Intervention Trial;Investigation;London;Medical Research;medical schools;Outcome;patient oriented;patient oriented research;Patients;Phase;Physicians;Postdoctoral Fellow;pragmatic trial;Preparation;prevent;Prevention Research;programs;Research;Research Project Grants;Research Training;Schools;Scientist;Tanzania;Training;Training Programs;Tropical Medicine;United States National Institutes of Health;Vaccine Research;Women's Health

PROJECT_TITLE: HIV and Women's Health


ADMINISTERING_IC: DA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Disability Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE This supplement addresses the critical need for firmer understanding of treatment history, clinical, demographic, community, and other factors associated with increasing fatal-overdose risk among minoritized communities, using 100% Medicare data with the statistical power to support accurate assessment across racial/ethnic subgroups and communities, which will provide insights with broad significance for overdose prevention across populations and payers. We will utilize 100% linked National Death Index-Medicare claims data in CMS’s Virtual Data Research Warehouse (VRDC) to expand statistical power for evolving patterns of fatal drug overdose across racial-ethnic subgroups and the role of community/health system factors and disparate access to medications for opioid use (MOUD) in these fatalities. We will create 100% cohorts of Medicare disability beneficiaries treated for non-fatal overdose; implement event history analyses of MOUD treatment and overdose fatality risk in these cohorts; assess the role of treatment disparities on fatal overdose; and identify the most promising targets in the treatment cascade for intervention to reduce outcome disparities.

PI_NAMEs: CRYSTAL, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: access disparities;Address;beneficiary;Buprenorphine;Cessation of life;Characteristics;Clinical;Code;cohort;Communities;comorbidity;Data;data centers;Data Linkages;Development;Diagnostic;Dimensions;disability;Disparate;Disparity;disparity reduction;dosage;Drug Prescriptions;Equity;Ethnic Origin;Ethnic Population;Event;Event History Analysis;Fee-for-Service Plans;Fentanyl;fentanyl use;hazard;Health Services Accessibility;Health system;Heroin;high risk;improved;indexing;insight;Intervention;Link;Managed Care;Measures;Medical;Medicare;Medicare claim;Mental Health;Methadone;methadone treatment;minority communities;Minority Enrollment;Minority Groups;Modality;Modeling;mortality;mortality disparity;Naltrexone;Opioid;opioid epidemic;opioid overdose;opioid use;Outcome;Outcome Assessment;outcome disparities;Overdose;overdose death;overdose prevention;Overdose reduction;overdose risk;Pattern;Penetration;Performance;Pharmaceutical Preparations;Phase;Policies;polysubstance use;Population;prescription opioid;programs;psychosocial;Race;Recording of previous events;Research;Research Personnel;Risk;Risk Reduction;Role;rural disparities;Sampling;Secure;Shapes;social vulnerability;Subgroup;Survivors;Time;treatment disparity;treatment optimization;treatment pattern;trend;uptake;Variant;virtual

PROJECT_TITLE: Enhanced Assessment of Overdose Mortality, Other OUD-Related Outcomes, Treatment Access and Equity Among Medicare Beneficiaries with Disability, Across Racial/Ethnic Subgroups and Communities


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PI_NAMEs: HODDER, SALLY LYNN (contact)

PROJECT_TERMS: Administrator;Appalachian Region;Clinic;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Unit;Collaborations;Communication;Communities;Community Health Education;Community of Practice;Community Participation;Community Trial;dashboard;Data;Death Rate;Diabetes Mellitus;electronic consent;Ensure;evidence base;experience;Feedback;Goals;Health;Health behavior;health communication;Health Personnel;Health system;High Prevalence;implementation process;implementation science;improved;Infrastructure;Learning;Malignant Neoplasms;Maps;Medical;member;Methodology;Modification;Obesity;Outcome;Overdose;Participant;Performance;performance site;Pharmaceutical Preparations;Population;practice-based research network;primary care practice;primary care provider;provider networks;Research;Research Institute;Rural;rural area;rural dwellers;Science;Site;Telemedicine;tool;Translating;Translational Research;Trust;West Virginia;Work

PROJECT_TITLE: West Virginia Rural Roots to Research


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative This study focuses on identifying the key proteins required to assemble a fully-functional phage nucleus and determining the roles that they play in phage replication. The work proposed here will provide new insight into the biology of these understudied viruses and the underlying principles of subcellular compartmentalization previously observed almost exclusively in eukaryotes.

PI_NAMEs: POGLIANO, JOSEPH A (contact);POGLIANO, KIT J;VILLA, ELIZABETH

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Bacteriophages;Biochemistry;biological systems;Biology;candidate identification;Capsid;Cell Nucleus;Cells;Cellular biology;Complex;Cryo-electron tomography;Cytoplasm;Data;design;DNA biosynthesis;DNA Packaging;DNA Repair;Docking;Escherichia coli;Eukaryota;Filament;Genetic;Genetic Recombination;Genetic Transcription;Genome;Goals;In Situ;In Vitro;Individual;Infection;insight;knock-down;Knowledge;live cell imaging;Membrane;Membrane Lipids;Messenger RNA;Metabolism;Molecular and Cellular Biology;mRNA Export;nucleotide metabolism;Play;Process;Protein Biosynthesis;protein expression;Protein Import;protein metabolism;Proteins;Pseudomonas;Pseudomonas aeruginosa;Research;Resolution;Role;segregation;self assembly;structural biology;Structure;Surface;Translation Process;Tubulin;Viral;Virus;Work

PROJECT_TITLE: Molecular and cellular biology of the phage nucleus and spindle

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Columbus

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative No change from original proposal.

PI_NAMEs: CEBULLA, COLLEEN MARIE (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Disease;Health;Retina;Role

PROJECT_TITLE: Characterization of the role of MIF on retinal health and disease

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE The results of this study will be used to make collaborative clinical and translational research more efficient and effective by creating new resources to support evidence-based information management for translational teams. This will, in turn, help advance health-related research move forward more quickly and provide a greater return on the investments made by public health funding agencies.

PI_NAMEs: ROLLAND, BETSY ANN (contact)

PROGRAM_OFFICER_NAME: WANG, YANLI

PROJECT_TERMS: Address;Agreement;Authorship;Behavior;bench to bedside;Biometry;cancer care;care delivery;Catalogs;Cellular biology;Clinical and Translational Science Awards;clinical implementation;Clinical Research;Collaborations;Communication;Communities;community engagement;Complex;Computer software;Data;digital;Discipline;Discipline of Nursing;Electronic Mail;Electronics;Ensure;Epidemiology;Equity;Evaluation;evidence base;Evidence based intervention;Fostering;Funding Agency;Future;Goals;Guidelines;Health;health equity;health management;Human;Hybrids;improved;Individual;Information Management;Information Sciences;Institution;Intervention;Investments;Knowledge;Learning Module;Maps;Measures;Methods;Oncology;Outcome;Outcomes Research;Participant;Persons;pilot test;Population;Practice Management;Process;product development;prototype;Public Health;Records;Reproducibility;Research;research and development;Research Personnel;Resources;Role;Science;Telephone;Testing;Text Messaging;Time;tool;Training;Translating;Translation Process;translational impact;translational pipeline;Translational Research;United States National Library of Medicine;usability;Wisconsin;Work;Work Simplification

PROJECT_TITLE: Enabling High-Impact Collaborative Clinical and Translational Research through Effective Information Management: A Prototype Intervention

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse

PHR: Public Health Relevance Statement The study's public health relevance lies in addressing the critical stage of the opioid crisis, characterized by staggering levels of illness and mortality, particularly prevalent in Ohio. By extending the O-SUDDEn project, it aims to develop a more accurate model for estimating opioid use disorder (OUD) prevalence, which can enhance existing predictive models and guide targeted public health interventions to mitigate opioid-related fatalities and improve overall health outcomes in Ohio.

PI_NAMEs: FAREED, NALEEF ;FERNANDEZ, SOLEDAD A (contact)

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: Accounting;Address;Affect;Area;Cessation of life;combat;Communities;County;COVID-19 pandemic;Data;data enclave;data integration;Data Linkages;Death Rate;Dedications;Demographic Impact;demographics;Derivation procedure;Development;Disparity;Education;Educational Status;Effectiveness of Interventions;Epidemic;epidemic potential;evidence base;experience;Face;Formulation;Funding Mechanisms;Geographic Locations;geographic population;Geography;Health;Health Insurance;Health Policy;Health Services Accessibility;Heterogeneity;HIV/HCV;Homelessness;Improve Access;improved;Incidence;Individual;Inequity;Infrastructure;Intervention;Knowledge;Legal system;Life;Link;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Nature;Ohio;Opioid;opioid epidemic;opioid misuse;opioid mortality;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose death;parent grant;Pattern;Persons;Pharmaceutical Preparations;Population;predictive modeling;Prevalence;Public Health;public health intervention;public health relevance;Reporting;Resolution;Resource Allocation;Resources;Risk;Risk Factors;Services;Social support;Socioeconomic Factors;substance use;Substance Use Disorder;Unemployment;United States;Variant;Vulnerable Populations;Work

PROJECT_TITLE: Enhancing Precision in Overdose Mortality Prediction through Data Linkage: A Heterogeneous Capture-Recapture Approach to Estimating Opioid Use Disorder Prevalence in Ohio


ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: NARRATIVE – PUBLIC HEALTH RELEVANCE STATEMENT Mitochondria are essential organelles in all eukaryotic cells, and their dysfunction has severe consequences in development and diseases. Mitochondria are highly dynamic through biogenesis, trafficking, changing morphology and targeted removal. Our research seeks fundamental understanding of the regulatory biology of mitochondria under normal physiology focusing on the crosstalk among mitochondrial dynamics, mitochondrial functions, cellular metabolism and signaling.

PI_NAMEs: ZHAO, MENG  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Bioenergetics;Biogenesis;Biology;Cell Differentiation process;Cell Lineage;Cell model;Cell Physiology;Cell Survival;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Cues;Defect;Development;Disease;Environment;Epigenetic Process;Eukaryotic Cell;Event;Excision;Functional disorder;Genetic;Genetic Transcription;high resolution imaging;Maintenance;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Mitochondria;mitochondrial metabolism;Modification;Morphology;Organ Culture Techniques;Organelles;Pathogenesis;pharmacologic;Physiology;Process;public health relevance;Publishing;Regulation;Research;Role;Signal Transduction;Specific qualifier value;stem cells;System;Therapeutic;tool;trafficking;Work

PROJECT_TITLE: The role of mitochondrial regulation in cell lineage specification and function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Lung;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: ALBANY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: Obstructive sleep apnea (OSA) is a major public health problem, which is more prevalent in older individuals. The sleep-related decrease of the tonus of upper airway muscles, which keeps airway open in wakefulness, is a key neurological cause of the airway occlusion in most OSA patients. Since noradrenergic neurons significantly contribute to the maintenance of upper airway muscle tone, we will determine whether the functioning of these noradrenergic neurons is impaired with age; this information will be helpful for developing proper therapeutic strategies for the clinical management of OSA in older patients.

PI_NAMEs: FENIK, VICTOR BORISOVICH;RUKHADZE, IRMA  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acceleration;Adult;Age;age effect;age related;age related changes;age-related disease;Aging;aging population;airway muscle;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid deposition;Anatomy;Arousal;Axon;base;Brain Stem;Cardiovascular system;Cell Nucleus;cell type;Chronic;Clinical;Clinical Management;Clinical Research;Clinical Trials;Coupling;Data;density;design;Dilator;Effectiveness;Elderly;Event;experience;experimental study;Female;Functional disorder;genetic approach;genioglossus muscle;Health;Hypercapnia;hypoglossal nucleus;Hypoxia;Impairment;improved;Link;locus ceruleus structure;Maintenance;male;Maps;Mental Depression;Metabolic;Methods;middle age;Molecular Genetics;Morbidity - disease rate;mortality;Motor Neurons;mouse model;Mus;Muscarinics;Muscle;Muscle Tonus;nerve injury;nerve supply;neurochemistry;Neurocognitive;Neurologic;Neurons;non rapid eye movement;noradrenergic;normal aging;novel;Obstructive Sleep Apnea;old mice;older adult;older patient;Older Population;Pathogenesis;Pathology;Patients;Pattern;pharmacologic;Play;pressure;Prevalence;Preventive;Prosencephalon;Public Health;Quality of life;Recurrence;Reflex action;REM Sleep;Reporting;Risk Factors;Role;Severities;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Fragmentations;System;Testing;Therapeutic;Tongue;Translational Research;transmission process;Viral Vector;Wakefulness;Work

PROJECT_TITLE: The impact of aging on the functional and anatomical coupling between brainstem noradrenergic neurons and upper airway muscles


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE HIV infection remains incurable because latently infected cells are intrinsically resistant to cell death, since HIV infected cells which survive initial infection are selected to be Bcl2 high; therefore, recent efforts have evaluated the Bcl2 antagonist Venetoclax to augment HIV infected cell death, with some success. Protein functions are often impacted by post translational modifications including phosphorylation, and herein we show that during HIV infection Bcl2 is phosphorylated, and our preliminary data suggests that these phosphorylation events cause fewer HIV infected cells to die and reduce susceptibility to the anti-HIV effects of Venetoclax. In this application, we will fully characterize the extent of Bcl2 phosphorylation during HIV infection, the propensity of HIV infected cells containing phopsho-Bcl2 to die following HIV replication and in response to immune effector pathways, and the impact of those phosphorylation events on the ability of Venetoclax to augment infected cell killing, as well as test strategies to overcome the phosphorylation of Bcl2 to favor elimination of HIV infected cells.

PI_NAMEs: BADLEY, ANDREW D (contact)

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Acute;Adopted;Affinity;antagonist;Apoptosis;Apoptotic;Autologous;Bad protein;BCL-2 Protein;BCL2 gene;Binding;Binding Proteins;Biological Assay;cancer cell;CD4/CD8 ratio procedure;Cell Death;Cell Death Induction;cell killing;Cell Line;Cell Survival;Cells;Cessation of life;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;cytotoxicity;Data;DNA;Effectiveness;Effector Cell;Event;Family;genetic regulatory protein;HIV;HIV Envelope Protein gp120;HIV Infections;HIV Protease;humanized mouse;IL7 gene;Immune;immune clearance;In Vitro;Infection;inhibitor;Jurkat Cells;Kinetics;Knock-out;Lymphoid Tissue;Measures;Mediating;Membrane Potentials;mimetics;Mitochondria;Molecular Conformation;mouse model;multicatalytic endopeptidase complex;Natural Killer Cells;novel;Pathway interactions;Phosphopeptides;Phosphorylation;Positioning Attribute;Post-Translational Protein Processing;Predisposition;prevent;pro-apoptotic protein;Proliferating;Protein Dephosphorylation;protein function;Proteins;reactivation from latency;Readiness;Reagent;Regulation;Reporting;Research;Resistance;response;Role;Site;small molecule;Stimulus;Structure;success;Surface Plasmon Resonance;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Time;tool;Transcript;Transfection;Tumor Necrosis Factor Ligand Superfamily Member 6;Variant;Viral;Viral Load result

PROJECT_TITLE: IMPACT OF BCL2 PHOSPHORYLATION ON HIV DYNAMICS, RESERVOIR SIZE AND SUSCEPTIBILITY TO VENETOCLAX

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: NUTRITION

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative This project seeks to better understand how HIV-1 spreads through cell-cell contact, an important route of viral infection. We have developed an innovative flow cytometry assay for quantifying and purifying infected cell- target cell pairs, which we will use to define determinants of VS formation and to purify interacting cells for powerful proteomic and transcriptomic analysis using ascorbate peroxidase (APEX) proximity labeling to quantify how host and viral proteins change in location over time following cell-cell contact. We will also examine the effect of cell-cell contact on transcription of the HIV provirus and regulation of viral RNAs, providing unprecedented detail into cell-cell spread of HIV that could lead to novel therapies to disrupt this important pathway.

PI_NAMEs: TILTON, JOHN CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Affect;Anti-Retroviral Agents;ascorbate;Binding;Bioinformatics;Biological Assay;Biology;Biotin;Biotinylation;CD4 Positive T Lymphocytes;Cell Communication;Cell Death;Cell Line;Cell membrane;Cell Nucleus;Cells;Chimeric Proteins;Complex;Cytoplasm;Cytoplasmic Tail;Cytoskeleton;Data;DNA;Elements;env Gene Products;Enzymes;experimental study;Flow Cytometry;Genetic Recombination;Genetic Transcription;Goals;Grant;HIV;HIV-1;Hour;Hydrogen Peroxide;Infection;innovation;insight;Intercellular adhesion molecule 1;intercellular communication;Label;Location;Measures;Membrane;Microtubules;Mitochondria;Molecular;nanometer;neutralizing antibody;novel;novel therapeutics;Nuclear;particle;Pathway interactions;Peroxidases;Pharmaceutical Preparations;Phenols;Phosphorylation;Physiological;Protein Analysis;protein expression;Proteins;Proteomics;Provirus Integration;Proviruses;Refractory;Regulation;Regulatory Pathway;Reporting;Rest;RNA;RNA-Binding Proteins;Role;Route;Signal Induction;Signal Transduction;Sorting;Structure;synaptogenesis;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Time;trafficking;Transcript;Transcriptional Regulation;transcriptomics;transmission process;Vaccine Design;vaccine efficacy;Vaccines;Viral;Viral Proteins;Viral reservoir;viral RNA;Virion;virological synapse;virology;Virus Assembly;Virus Diseases;Virus Latency

PROJECT_TITLE: Gaining a clear view of HIV cell-cell spread using APEX proximity labeling


PHR: PROJECT NARRATIVE Despite nearly four decades of research, we still do not have an HIV cure or vaccine, and curative drug trials in people living with HIV (PLWH) have thus far had minimal impact on achieving a durable “antiretroviral therapy (ART)-free remission.” The goal of the proposed work is to address a critical need – to determine host mechanisms that “naturally” drive long-term HIV control throughout various stages of HIV, in order to identify potential novel future drug candidates for HIV cure. Based on our preliminary data, we hypothesize that specific antiviral cytokines (IL-10, interferons) dynamically control virus at different stages of HIV: acute HIV infection (AHI), ART initiation (ARTi), ART suppression (ART+), and ART interruption (ATI), and that findings from this study will help inform future HIV cure trial design as well as other class II cytokine-mediated diseases (e.g., cancer, autoimmune disorders).

PI_NAMEs: ABDEL MOHSEN, MOHAMED ;LEE, SULGGI ANGELA (contact);ROAN, NADIA R

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acute;Address;aging related disease;Anti-Retroviral Agents;antiretroviral therapy;Autoimmune Diseases;Binding;Biological Assay;Blood;CD4 Positive T Lymphocytes;Cell Survival;Cells;Clinical;cohort;Complex;cytokine;Data;Diagnosis;Disease;Disease remission;drug candidate;Elements;Exhibits;FCGR3B gene;Funding;Future;Glutamates;Goals;Grant;HIV;HIV Infections;Immune;improved;in vivo;Infection;Inflammation;Interferon Type I;Interferons;Interleukin-10;interleukin-19;Interruption;Intervention;Lead;Lipids;Lymph Node Tissue;lymph nodes;Maintenance;Malignant Neoplasms;Measures;Mediating;Metabolic;Monitor;Mucous Membrane;Natural Killer Cells;NCAM1 gene;novel;novel therapeutics;Outcome;Participant;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phenotype;Plasma;Polysaccharides;Population;Proteins;Research;response;Role;Sampling;Site;SIV;Specificity;standard measure;T cell response;therapeutic candidate;Time;Tissue Sample;Tissues;transmission process;trial design;Vaccines;Viral;viral rebound;Virus;Work

PROJECT_TITLE: STudy of Acute HIV for investiGating Eradication Strategies (STAGES)


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE: HIV-1 infects millions of people and there is no effective vaccine available. Our recent data suggest that vaccines could be improved by reducing the prime dose. Our proposal will follow up on these findings with the goal of developing more effective mRNA-based and Ad-based HIV-1 vaccines.

PI_NAMEs: PENALOZA, PABLO  (contact)

PROGRAM_OFFICER_NAME: MALASPINA, ANGELA

PROJECT_TERMS: 2019-nCoV;Accidents;adaptive immune response;Adaptive Immune System;Adenoviruses;Affect;Antibodies;Antibody Response;Antigens;antiretroviral therapy;antiviral immunity;Applications Grants;Codon Nucleotides;Communicable Diseases;Data;Disease;Dose;efficacy testing;Evaluation;follow-up;Fractionation;Functional disorder;Goals;HIV;HIV envelope protein;HIV vaccine;HIV Vaccine Trials Network;HIV-1;HIV/SIV vaccine;Immune response;Immunity;Immunize;immunogenic;immunogenicity;Immunologics;improved;Infection;Infection prevention;Laboratories;Length;Licensure;Light;Macaca;Messenger RNA;Mucosal Immune Responses;Mus;neutralizing antibody;novel;novel coronavirus;Persons;prevent;Primates;protective efficacy;Pseudouridine;Publications;Publishing;Research;Research Priority;RNA vaccine;Role;Safety;Scheme;Signal Transduction;simian human immunodeficiency virus;SIV;T-Lymphocyte;Testing;Vaccination;vaccination outcome;vaccine access;vaccine candidate;Vaccine Design;vaccine development;vaccine efficacy;vaccine immunogenicity;vaccine platform;vaccine trial;Vaccines;vector vaccine;Viral Antigens;Viral reservoir;Virus

PROJECT_TITLE: Enhancing HIV-1 vaccines by altering vaccine dose

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: NARRATIVE Maturation of the HIV-1 capsid is an essential step during the biogenesis of infectious virions. Maturation occurs when the viral protease cleaves the Gag protein into its constituent domains. The proposed research will lead to a better understanding of the mechanism by which the viral protease proteolytically processes Gag, how the dynamics of Gag and the immature virion regulate the timing of this process, and the evolutionary constraints that the virus faces in order to maintain efficient proteolysis and maturation.

PI_NAMEs: MUNRO, JAMES B (contact);SCHIFFER, CELIA A.

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Biogenesis;Biophysics;Capsid;Complex;convolutional neural network;Cryo-electron tomography;Data;Development;dimer;Dimerization;Ensure;Event;Evolution;experimental study;Face;flexibility;Fluorescence Resonance Energy Transfer;gag Gene Products;HIV;HIV-1;Image;Individual;inhibitor;interest;Kinetics;Laboratories;Length;Maintenance;Modeling;Molecular;Molecular Conformation;molecular dynamics;monomer;Morphology;Motion;Mutation;next generation;Peptide Hydrolases;Polyproteins;Process;Protease Inhibitor;Proteolysis;Proteolytic Processing;Research;Resistance;Resolution;Role;simulation;single molecule;Site;Structure;Testing;Variant;Viral;Virion;Virus;Virus Activation;Visualization

PROJECT_TITLE: Dynamics and Evolution of HIV Gag and GagPol processing


ORG_DEPT: PATHOLOGY

PHR: HIV remains a leading cause of morbidity and mortality worldwide, and while antiretroviral therapy has markedly improved the clinical outlook for patients, the therapy needs to be maintained for life to block renewed viral replication. In efforts to achieve permanent control of HIV replication without continued ART (HIV cure), this project proposes to explore the safety and therapeutic potential of a novel treatment strategy, by testing the synergy between an immune enhancing cytokine, IL- 15 and IL-15 receptor alpha, while blocking the immune dampening pathway of another cytokine, transforming growth factor beta. This approach will enhance antiviral responses while also reactivate cells housing latent virus towards their elimination, in addition this strategy will then be further combined with a novel therapeutic vaccination against HIV/SIV to attempt to achieve durable control of viral replication beyond antiretroviral treatment

PI_NAMEs: PODANY, ANTHONY T;VELU, VIJAYAKUMAR  (contact);VILLINGER, FRANCOIS J

PROJECT_TERMS: Address;Adjuvant;Affect;Animal Euthanasia;Anti-Retroviral Agents;Anti-viral Response;antiretroviral therapy;antiviral immunity;B-Lymphocytes;Binding;Biological Availability;Blood;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Chronic;Clinical;Combined Modality Therapy;Complex;cytokine;cytokine therapy;cytotoxic;Data;Disease remission;DNA;DNA/MVA vaccine;effective therapy;effector T cell;Endothelial Cells;Exclusion;functional restoration;Goals;Helper-Inducer T-Lymphocyte;HIV;HIV Infections;HIV-1;Homing;Housing;Human;Immune;Immunity;Immunization;improved;In Vitro;in vivo;Infection;inhibitor;Interleukin-15;interleukin-15 receptor;Interruption;Knowledge;Life;lymph nodes;Lymphoid;Lymphoid Tissue;Macaca;Macaca mulatta;Modeling;Morbidity - disease rate;mortality;Natural Killer Cells;novel;novel strategies;novel therapeutics;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Play;Population;Proliferating;Publishing;response;Rest;restoration;RNA;Role;Safety;Sampling;secondary lymphoid organ;SIV;SIV Vaccines;Structure of germinal center of lymph node;synergism;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Tissues;TNFSF5 gene;Transforming Growth Factor beta;Treatment Efficacy;treatment strategy;Vaccination;Vaccine Therapy;Viral;Viral Physiology;viral rebound;Viral reservoir;Viremia;Virus Latency;Virus Replication;Work

PROJECT_TITLE: IL-15 Therapy Combined with TGF-Beta Blockade for Sustained HIV Remission


NIH_SPENDING_CATS: Bioengineering;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Nanotechnology

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project narrative HIV persists during therapy by its ability to enter a state of latent infection in CD4 T cells. A key challenge in the field is defining the molecular mechanisms that regulate HIV expression and contribute to maintaining the latent state. In this proposal we will capitalize on our prior findings to identify novel combinations of gene knockouts and small molecule inhibitors that can synergize with our validated HIV regulating factors to achieve broad reactivation of the clinical reservoir.

PI_NAMEs: BROWNE, EDWARD P (contact)

PROJECT_TERMS: access restrictions;analytical tool;Animal Model;antiretroviral therapy;Benchmarking;CD4 Positive T Lymphocytes;Cell Line;Cell model;Cells;Chemicals;Chromatin;Clinical;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combinatorial;Complex;COVID-19 vaccine;CRISPR screen;Data;Data Set;Drug Combinations;Engineering;Environment;Epigenetic Process;epigenome;epigenomics;explainable machine learning;Gene Combinations;Genes;Genetic Transcription;Heterochromatin;HIV;HIV Infections;Immune system;improved;Individual;Integration Host Factors;integration site;Interruption;Intervention;Knock-out;knockout gene;latent infection;Lead;Libraries;lipid nanoparticle;Logic;machine learning model;Mediating;Messenger RNA;Modeling;Molecular;Nature;novel;Pathway interactions;Persons;Population;predictive modeling;programs;Provirus Integration;Proviruses;reactivation from latency;Regulation;Repression;Research;Rest;RNA;RNA delivery;screening;single cell analysis;Small Interfering RNA;small molecule;small molecule inhibitor;success;synergism;Testing;tool;Training;Transcript;transcription factor;transcriptome;transcriptomics;Universities;Viral;viral rebound

PROJECT_TITLE: Regulation of HIV Latency by Host Cell Transcriptional and Epigenetic Networks


ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE During antiretroviral treatment (ART) in people living with HIV (PWH), latently HIV-infected cells reside primarily in lymph nodes, spleen and gut-associated lymphoid tissues and sporadically produce virus. Little is known about factors that induce latently HIV-infected cells to produce virus, but we believe that B cells in the tissue microenvironment play an important role. This project will define the role of B cells and other immune cells in the microenvironment in promoting virus expression with the long term goal of developing strategies to reverse or alternatively enhance viral latency in vivo to achieve a functional remission of HIV.

PI_NAMEs: CONNICK, ELIZABETH  (contact);GIANELLA WEIBEL, SARA

PROJECT_TERMS: Antibodies;antiretroviral therapy;Autologous;B-Lymphocyte Subsets;B-Lymphocytes;Binding;CD4 Positive T Lymphocytes;Cell Survival;Cells;cytokine;Data;Disease remission;Euthanasia;Frequencies;Gene Expression Profiling;Genetic Transcription;Goals;Gut associated lymphoid tissue;HIV;HIV Infections;HIV-1;Human body;ileum;Immune;immune activation;Immunologic Factors;Immunologic Markers;Impairment;In Situ Hybridization;in vivo;Incubated;Individual;Infection;Interleukin-10;Knowledge;Location;Lymph Node Tissue;lymph nodes;Lymphoid Tissue;Macaca mulatta;Memory;Memory B-Lymphocyte;Minority;Modeling;novel strategies;Persons;Phenotype;Play;Reporter;RNA;Role;SIV;Source;Spleen;Structure of germinal center of lymph node;Techniques;Tissues;Tonsil;tumor-immune system interactions;Up-Regulation;viral RNA;Viremia;Virus;Virus Latency;Virus Replication

PROJECT_TITLE: Immune Microenvironments That Impact HIV Persistence and Expression During ART


ADMINISTERING_IC: ES

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: SILVER SPRING

ORG_NAME: SOCIAL AND SCIENTIFIC SYSTEMS,  INC.

ORG_STATE: MD

PI_NAMEs: VIRAY, LAUREN  (contact)

PROJECT_TITLE: TASK ORDER NO. 75N96021F00001PERIOD OF PERFORMANCE: 06/30/2021-06/29/2022COST-REIMBURSEMENT, SEVERABLE


PROJECT_TERMS: Adherence;Budgets;Contracts;Ensure;Epidemiology;Modification;Monitor;Office of Administrative Management;Research Personnel;Resources;Services;Support Contracts;timeline;Vendor

PROJECT_TITLE: TASK ORDER 1R - ADMINISTRATIVE MANAGEMENT AND SUPPORT


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Physical Injury - Accidents and Adverse Effects

ORG_NAME: CERAMEDIX HOLDING, LLC

PI_NAMEs: DIMMLER III, CHARLES  (contact)

PROJECT_TERMS: Acute;Address;Animal Experimentation;Apoptosis;Biological;biomarker development;Blood Vessels;Cessation of life;Development;Endothelium;FDA approved;Female;gastrointestinal;Injury;Ionizing radiation;irradiation;male;medical countermeasure;Modeling;Mus;novel;Organ failure;Pegfilgrastim;Radiation;Radiation Accidents;radiation effect;Radiation exposure;Radiation Injuries;Radiation Toxicity;radiation-induced injury;response;Testing;Vascular Endothelium

PROJECT_TITLE: DEVELOPMENT OF ANTICERAMIDE TREATMENT AS A NOVEL MEDICAL COUNTERMEASURE FOR ACUTE EFFECTS OF RADIATION EXPOSURE


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: ROCKVILLE

ORG_NAME: CTIS, INC.

PI_NAMEs: RAJU, SUDHIR  (contact)

PROJECT_TERMS: Achievement;Address;Businesses;cancer clinical trial;Cancer Therapy Evaluation Program;Clinical;Communication;Community Clinical Oncology Program;Computers;Contracts;cost effective;Data;Data Collection;design;Development;empowerment;Ensure;Future;Goals;Human Resources;Improve Access;improved;Informatics;Information Storage;innovation;Methods;Patients;Physicians;Safety;Science;Scientist;Security;Support Contracts;System;tool;Toxic effect

PROJECT_TITLE: CANCER THERAPY EVALUATION PROGRAM INFORMATICS & COMPUTER SUPPORT


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

PHR: Adrenocortical carcinoma (ACC) occurs across the lifespan in young and older veterans and is an aggressive malignancy with poor survival of <35% at 5 years. Patients with genetic syndromes including Li-Fraumeni, Beckwith-Wiedmann and Lynch syndrome are predisposed to developing ACC; however, the majority of cases have no known cause. Slow progress in the field has been attributable to the lack of any preclinical models. We have transformed the field with the first new ACC cell lines and patient derived xenograft mouse models (PDX). We then used bioinformatic approaches to identify alterations in cell cycle and DNA damage repair pathways as new targets to explore mechanism of action. This proposal will focus on the role of a dysregulated mitotic kinase in ACC, PBK. Our models will allow testing of PBK inhibition together with Mitotane towards a new treatments for our patients with this deadly disease.

PI_NAMEs: KISELJAKVASSILIADES, KATJA  (contact);WIERMAN, MARGARET E

PROJECT_TERMS: Adrenal Gland Cancer;Adrenocortical Carcinoma;Affect;Age;Animal Model;Area;Beckwith-Wiedemann Syndrome;beta catenin;Bioinformatics;Biology;Breast;Candidate Disease Gene;Cell Cycle;Cell Cycle Regulation;Cell Line;Cell model;Cell Proliferation;Cell Survival;Cells;Cellular Structures;chemotherapy;Clinic;Clinical Trials;Colon;Cytokinesis;Data;Databases;Development;Disease;DNA Damage;DNA Repair;effectiveness testing;Effector Cell;Endocrine;endoplasmic reticulum stress;experimental study;FDA approved;Female;Genes;Genetic;Genomics;Goals;Growth;Hereditary Nonpolyposis Colorectal Neoplasms;Human;human tissue;In Vitro;in vivo;insight;Investigation;kinase inhibitor;life span;Light;Lung;Lymphoma;male;Malignant Neoplasms;malignant phenotype;Mitotic;Modeling;Molecular;Molecular Profiling;mouse model;Mutation;new therapeutic target;novel;novel therapeutics;Nude Mice;Operative Surgical Procedures;Orphan;overexpression;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;PDZ-binding kinase;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Pre-Clinical Model;Prostate;Proteins;response;Risk;Role;Syndrome;Testing;Therapeutic Agents;Time;TP53 gene;Translations;tumor;Tumor Cell Line;tumor growth;tumorigenesis;tumorigenic;Tumorigenicity;Veterans;Xenograft procedure

PROJECT_TITLE: Targeting Kinases in Novel Preclinical Models of Adrenocortical Carcinoma


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cancer;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Depression;Digestive Diseases;Mental Health;Neurosciences;Pain Research;Palliative Care;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Head and neck cancer patients experience severe pain and stress. The proposed studies investigate how sympathetic and sensory nerves interact to drive cancer pain and promote cancer growth. This approach has the potential for new therapeutic strategies to treat cancer progression and pain by targeting neurons.

PI_NAMEs: SCHEFF, NICOLE N (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Address;Adrenergic Agents;Adrenergic Antagonists;Adrenergic beta-Antagonists;Adrenergic Receptor;afferent nerve;Afferent Neurons;Aftercare;Animal Model;antagonist;Anxiety;Behavior;Behavioral;Benign;beta-adrenergic receptor;Biological;Breast;Calcium;cancer cell;cancer diagnosis;cancer invasiveness;cancer pain;Cancer Patient;carcinogenesis;Catecholamines;Cell Proliferation;Cells;chemical carcinogen;chronic pain;Chronic stress;Clinical;Clinical Trials;Combined Modality Therapy;Data;Disease Progression;Dose;drinking water;Electrophysiology (science);emotional experience;experience;gastrointestinal;Goals;Growth;Growth and Development function;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;improved outcome;In Vitro;in vivo;Incidence;Inflammation;Injury;Long-Term Effects;malignant mouth neoplasm;Malignant Neoplasms;Measures;Mediating;Mediator;Mental Depression;Metastatic Neoplasm to Lymph Nodes;Microscopy;mouse model;Mus;Nerve;nerve supply;Neurons;Neuropeptides;neurotransmission;Nociception;Norepinephrine;novel therapeutic intervention;Optics;Oral;Oral cavity;oral lesion;orofacial;Pain;pain behavior;Pain management;pain symptom;palliation;Patient Outcomes Assessments;Patients;Peripheral;Peripheral Nerves;Phase;Physiological;Plasma;pre-clinical;Pre-Clinical Model;Predisposition;prognostic;prognostic indicator;Propranolol;prospective;Prostate;Psychological Impact;Psychological Stress;psychological symptom;psychosocial;Psychosocial Stress;Quality of life;receptor expression;receptor function;Receptor Signaling;Reporting;Resolution;Risk Factors;Signal Transduction;Social support;Stains;Stress;Survivors;survivorship;Sympathectomy;Sympathetic Nervous System;Symptom Burden;Testing;Therapeutic;Tongue;Treatment Protocols;Treatment-Related Cancer;Trigeminal System;tumor;tumor microenvironment;tumor progression;tumorigenesis;Visualization;Xenograft procedure

PROJECT_TITLE: Sympathetic modulation of head and neck cancer pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Cardiovascular;Congenital Heart Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Mental Health;Patient Safety;Pediatric;Prevention;Rare Diseases;Sleep Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative Valvular Heart Disease is a prevalent condition that put patients at risk for morbidity and mortality. Postoperative cardiac arrhythmias, including both atrial and ventricular arrhythmias, as well as post- operative delirium are a major source of morbidity and mortality for VHD patients. Investigators in the Cardiothoracic Surgical Trials Network (CTSN) propose several novel approaches to better understand the risk factors and trajectory of post-operative events, as well as disparities in treatment approaches.

PI_NAMEs: GELIJNS, ANNE CHRISTINE (contact);MOSKOWITZ, ALAN J

PROGRAM_OFFICER_NAME: BURKE, CATHERINE

PROJECT_TERMS: accelerated epigenetic aging;Adult;adverse event risk;Age;aortic valve;Aortic Valve Stenosis;Arrhythmia;Artificial Intelligence;Atrial Fibrillation;biological age;Biological Markers;Cardiovascular system;Categories;Cessation of life;Chronology;Circadian Dysregulation;Circadian Rhythms;Clinical;Clinical Management;Clinical Practice Guideline;Coronary Arteriosclerosis;cost;Data;Data Set;Day Surgery;Delirium;Devices;Diagnostic;Diagnostic tests;Disease;Disparity;Electrocardiogram;Electrophysiology (science);Ethnic Origin;Event;experience;follow-up;Future;Heart Atrium;Heart Valve Diseases;high risk;high risk population;Hospitalization;Hospitals;Hydrocortisone;Image;Impaired cognition;Incidence;indexing;Individual;insight;Intervention;Ischemia;Knowledge;Left;Left Ventricular Remodeling;Machine Learning;Measures;Melatonin;Mitral Valve;Mitral Valve Insufficiency;Mitral Valve Prolapse;Monitor;Morbidity - disease rate;mortality;Myocardial tissue;neural network;novel;novel strategies;Operative Surgical Procedures;Outcome;outcome prediction;Outpatients;patient subsets;Patient-Focused Outcomes;Patients;Perioperative;Phototherapy;Play;Populations at Risk;post intervention;posthospitalization care;postoperative delirium;Postoperative Period;Prediction of Response to Therapy;prevent;Procedures;prognostic;Property;Race;radiomics;Recommendation;repaired;Reporting;Research;Research Personnel;Risk;Risk Factors;Role;rural area;Severities;sex;Sex Differences;Skilled Nursing Facilities;Sleep;Sleep disturbances;Socioeconomic Status;Source;Sudden Death;Telemetry;Therapeutic;Time;treatment disparity;Tricuspid valve structure;Underrepresented Populations;Variant;Ventricular Arrhythmia;Visit

PROJECT_TITLE: REVISED CAROL ACT II


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Microbiome;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research will be the first longitudinal study to examine the effects of prenatal and postnatal exposure to air pollutants on the gut microbiome and fecal metabolome, and on subsequent brain measures and neurodevelopmental outcomes. Study findings will address a critical gap in our current understanding of the harmful effects of air pollution in early life, particularly alterations in gut bacterial species and fecal metabolic pathways that contribute to altered brain development and poorer neurodevelopmental outcomes.

PI_NAMEs: ALDERETE, TANYA LYNN (contact);PETERSON, BRADLEY S

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Address;Adult;Affect;Age Months;Air Pollutants;Air Pollution;Amino Acids;Animal Model;Anxiety;Archives;Attention deficit hyperactivity disorder;Attenuated;autism spectrum disorder;Bacteroides;Behavioral;Bile Acids;Birth;Blood flow;Brain;brain magnetic resonance imaging;brain tissue;Child;Childhood;Clostridium;Cognition;Cognitive;cognitive ability;cognitive development;cognitive performance;cognitive testing;cohort;County;Data;Development;Developmental Delay Disorders;DNA sequencing;early life exposure;economic cost;Emotional;Environmental Exposure;Exposure to;fecal metabolome;Feces;feeding;follow-up;frontal lobe;Funding;Growth;gut bacteria;gut microbiome;Health;Hippocampus;Human;Impairment;infancy;Infant;infant gut microbiome;Inflammation;Intervention;Knowledge;knowledge base;Language;Lateral;Latino;Learning Disabilities;Life;Link;Lipid Peroxidation;Lipids;Literature;Longitudinal Studies;Los Angeles;Magnetic Resonance Imaging;Maternal Health;Measures;Mediating;Mediator;Mental Depression;Mental disorders;Metabolic Pathway;metabolic profile;metabolomics;Metagenomics;microbial;Microglia;mother nutrition;Mothers;Motor;multidisciplinary;multimodality;myelination;Neurocognitive;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;novel;Nutritional;Outcome;Oxidative Stress;Parietal Lobe;Pathway interactions;Physiology;Population;postnatal;postnatal period;prenatal;prenatal exposure;prevent;Production;prospective;Research;Research Personnel;Rest;Role;School-Age Population;stool sample;Structure;Temporal Lobe;Testing;underserved community;United States National Institutes of Health;Variant;Volatile Fatty Acids;white matter

PROJECT_TITLE: Pre- and Postnatal Exposure to Air Pollutants and the Gut Microbiome: Implications for Brain Development in Early and Mid-Childhood

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Rehabilitation;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SEATTLE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Severe stroke is common, disabling, and often deadly, with most survivors suffering substantial post-stroke cognitive impairment -- also known as vascular contributions to cognitive impairment & dementia (VCID). While palliative care is increasingly recognized as a specialty with expertise in reducing suffering and improving patient and family-centered decision making in people with serious illness, no interventions have been developed that specifically target the unique needs of people affected by stroke and subsequent VCID. This project will improve patient and family outcomes and quality of care by providing longitudinal transdisciplinary support from early in the hospital stay for six months.

PI_NAMEs: CREUTZFELDT, CLAIRE JOHANNA (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: acceptability and feasibility;Acute;Acute Brain Injuries;Address;Affect;Alzheimer's disease related dementia;Anxiety;anxiety symptoms;anxious;Appointment;attentional control;Awareness;care providers;Caregiver Burden;caregiver strain;Caring;Cessation of life;Chronic;Chronic Disease;Cognition;cognitive disability;cognitive function;cohort;Cohort Studies;Communication;comparison control;comparison intervention;coping;Decision Making;Dementia;Depressed mood;depressive symptoms;Disabling;Disease;disparity elimination;Dissemination and Implementation;Distress;efficacy evaluation;efficacy trial;Emergency department visit;Enrollment;Ensure;Equity;Ethnic Origin;Evaluation;Event;experience;Face;Family;Family Caregiver;Family member;functional disability;future implementation;Goals;Grief reaction;health care service utilization;Healthcare;hospital readmission;Hospitalization;Hospitals;Hour;Hydration status;Immunologics;Impaired cognition;implementation evaluation;implementation facilitators;implementation intervention;improved;improved outcome;Incidence;Intervention;intervention refinement;Interview;Knowledge;Left;Length of Stay;Life;Malignant Neoplasms;Mechanical ventilation;Medical;medical specialties;Mental Depression;Mental Health;Methods;Modeling;Neurologic;novel;Nurses;nutrition;Outcome;Outcome Measure;pain symptom;Palliative Care;Patient Care;Patient Self-Report;Patient-Focused Outcomes;Patients;Persons;Physical Function;physical impairment;Population;post stroke;post stroke cognitive impairment;preference;primary outcome;Process;process evaluation;prognostic;Provider;provider communication;psychological outcomes;psychosocial;Quality of Care;Quantitative Evaluations;Race;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recovery;Rehabilitation therapy;Reporting;Research;Role;secondary outcome;Self Efficacy;Severity of illness;social;Social Work;socioeconomics;Spiritual care;Spirituality;Stroke;stroke survivor;stroke therapy;Survivors;Symptom Burden;symptomatic improvement;Symptoms;telehealth;Time;Training;treatment as usual;Treatment Efficacy;Uncertainty;Variant;Vascular Cognitive Impairment;Work

PROJECT_TITLE: Longitudinal transdisciplinary Neuropalliative care Support for Patients with Severe Stroke and their Families

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Both α-synuclein aggregates in the brain and mutations in the gene GBA1 associate with cognitive decline in Parkinson’s disease and Dementia with Lewy bodies. The goal of this project is the determine if the lipid, glucosylsphingosine, plays a role in toxicity caused by pathologic α-syn and mutant GBA1. We will accomplish this using mouse models of mutant GBA1 and α-synuclein aggregations along with analysis of glucosylsphingosine in cortex and limbic regions from human PD-GBA1 patients.

PI_NAMEs: VOLPICELLI-DALEY, LAURA A. (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: alpha synuclein;Area;Behavior;Behavioral;Brain;Brain region;brain tissue;Cognition;cognitive change;Cognitive deficits;cognitive impairment in Parkinson's;debilitating symptom;Defect;Dementia with Lewy Bodies;Development;Diagnosis;Disease;enzyme activity;Enzymes;Executive Dysfunction;Genes;Genetic Variation;glucosylceramidase;Glucosylceramides;glucosylsphingosine;Glycosphingolipids;Goals;Health;Heterozygote;Hippocampus;Human;human model;Impaired cognition;Impairment;Individual;Institutionalization;Lewy Body Dementia;Lewy body pathology;Lipids;Lysosomes;Metabolism;Methods;Motor;Mus;mutant;mutant mouse model;Mutation;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurons;Parkinson Disease;Parkinson's Dementia;Parkinsonian Disorders;Pathologic;Pathology;Patients;Performance;Physiology;prevent;Proteins;Risk;Role;Short-Term Memory;Synapses;Therapeutic;Toxic effect;Visuospatial;Wild Type Mouse

PROJECT_TITLE: Role of GlcSph in cognitive deficits in Lewy body dementias


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Coronary artery disease is a major cause of death around the globe, yet there are currently no strategies to regenerate diseased coronary arteries. We hypothesize that studying how the developing embryo builds coronary arteries from the ground up could reveal ways of rebuilding them in diseased hearts. We identified candidate developmental pathways during the previous funding period, and propose here to study whether and how these pathways stimulate coronary regeneration.

PI_NAMEs: RED-HORSE, MARY  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Anatomy;Angiogenic Proteins;Arteries;Automobile Driving;Biology;Blood capillaries;Blood flow;blood perfusion;Blood Preservation;Blood Vessels;Bypass;candidate identification;Cardiac;cardiac regeneration;cardiac vasculature;cardiogenesis;Cardiovascular system;Cause of Death;cell behavior;Cell Differentiation process;Cells;chemokine;ChIP-seq;Clinical;collaborative environment;Communities;Computer Models;Coronary;Coronary Arteriosclerosis;Coronary artery;CXCR4 gene;Data;Development;Developmental Gene;Embryo;Endothelial Cells;Ensure;Equus caballus;experimental study;Fibroblast Growth Factor;Funding;gain of function;Gene Expression;Genes;Genetic Transcription;Goals;Growth;Heart;Heart Diseases;Heart Injuries;Human;Image;Imaging technology;In Vitro;in vitro Model;in vivo;injured;Injury;innovation;Knowledge;Laboratories;Learning;loss of function;Maps;mechanotransduction;Medical;Methods;Modeling;Molecular;Morphogenesis;Myocardial Infarction;Myocardial Ischemia;Myocardium;Natural regeneration;Neonatal;novel;novel imaging technique;novel strategies;Operative Surgical Procedures;Organ;Outcome;overexpression;Oxygen;Pathway interactions;Patients;Pattern;protein expression;Recovery;Regimen;reparative capacity;Research;Research Personnel;Resolution;revascularization;Signal Transduction;Stromal Cell-Derived Factor 1;Structure;success;Techniques;Testing;Therapeutic Intervention;Tissue Survival;Tissues;transcription factor;Transcriptional Regulation;transcriptome sequencing;Travel;Trees;Universities;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Mechanotransduction and transcriptional regulation during artery development

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative We propose to develop a cell type specific and temporal specific epigenome editing tool that will have the capability of altering epigenetic marks or transcription marks on opioid disrupted gene loci in specific neuron subtypes. We will test these tools in specific neuron subtypes in the brain in opioid mediate gene expression networks and behaviors.

PI_NAMEs: LOBO, MARY KAY  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Abstinence;addiction;Animals;Attention;Behavior;Behavioral;behavioral outcome;behavioral response;Brain;brain cell;Brain region;brain reward regions;Cell Nucleus;cell type;Cells;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;Cocaine;combat;CRISPR interference;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;Dependence;design;Discipline;Dopamine Receptor;drug of abuse;Epidemic;Epigenetic Process;epigenome;epigenome editing;Fentanyl;fentanyl exposure;Fluorescence;Gene Expression;gene network;Genes;Genetic Transcription;genomic locus;Goals;Guide RNA;Health;histone modification;Implant;improved;in vivo;inducible Cre;Injections;Intake;knock-down;Light;Lighting;Luciferases;Mediating;Molecular;Motivation;Mus;Neurobiology;Neurons;Neurosciences;Nucleus Accumbens;Opioid;opioid abuse;opioid exposure;opioid overdose;opioid use;opioid use disorder;optical fiber;optogenetics;Overdose;overexpression;Pharmaceutical Preparations;Phase;Predisposition;prevent;Process;prolonged abstinence;Quantitative Reverse Transcriptase PCR;Regulation;Relapse;Renilla Luciferases;RNA;social stress;Sorting;Source;Specificity;Stress;synthetic opioid;Testing;Time;tool;transcription factor;transcriptome sequencing;translatome;vector;Water;Zinc Fingers

PROJECT_TITLE: Epigenome Editing in Opioid Action


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Neurosciences;Nutrition;Obesity;Women's Health Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: NARRATIVE Patients with sleep apnea are at increased risk of developing cardiovascular disease – with women at potentially greater risk than men. Contributing mechanisms are not well understood, but may be related to how women respond to low oxygen and, given over 70% of patients with sleep apnea are obese, the impact of obesity. The proposed project seeks to increase our understanding of mechanisms that may contribute to sex differences in the cardiovascular response to low oxygen with the hope that this knowledge will improve the efficacy of current therapies and support the discovery of novel therapeutics.

PI_NAMEs: LIMBERG, JACQUELINE K (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Acute;Adrenergic Agents;Adrenergic alpha-Agonists;Adrenergic Antagonists;Adrenergic beta-Agonists;Adult;adult obesity;alpha-adrenergic receptor;Area;Attenuated;beta-adrenergic receptor;Blood flow;Blood Pressure;blood pressure elevation;Blood Vessels;Body mass index;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Catecholamines;Chronic;Cohort Studies;constriction;Data;Development;Dexmedetomidine;Disproportionately impacts women;Endothelial Cells;epidemiologic data;ESR1 gene;Estrogens;Exhibits;Exposure to;Failure;falls;Female;Forearm;Functional disorder;Goals;high risk;Human;Hypertension;Hypoxemia;Hypoxia;Impairment;improved;ineffective therapies;Infusion procedures;Intervention;Intra-Arterial Infusions;Isoproterenol;Knowledge;Measures;Mediating;men;mortality;Muscle;Nerve;Neurotransmitters;neurovascular;Nitric Oxide;Norepinephrine;normoxia;novel therapeutics;Obesity;Overweight;Oxygen;Pathogenesis;Patients;Peripheral;peripheral blood;Pharmaceutical Preparations;pharmacologic;Phentolamine;Phenylephrine;Physiological;Plasma;Population;pre-clinical;Premenopause;preservation;Prevalence;prevent;Propranolol;Receptor Activation;receptor sensitivity;Regulation;Relaxation;Research;Resistance;response;Risk;Risk Factors;Role;sex;Sex Differences;sex disparity;Skeletal Muscle;Sleep Apnea Syndromes;Stress;Sympathetic Nervous System;Testing;vasoconstriction;Vasoconstrictor Agents;Vasodilation;Weight;Woman;women patients;women versus men;Work;young man;young woman

PROJECT_TITLE: Sex disparities in hypoxic sympatholysis and impact of obesity

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Neurosciences

PHR: MSTP Project Narrative Progress towards solving major health problems will require a steady source of well-trained new investigators who have the clinical background to appreciate major medical issues and the research skills to tackle them. Over the years, MD-PhD programs have proven to be a highly effective way to train such investigators. We seek funding to continue our highly successful MD-PhD Program at The Johns Hopkins University School of Medicine.

PI_NAMEs: COX, ANDREA L (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program


ADMINISTERING_IC: NS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Not applicable per solicitation. Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRAsystems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.

PI_NAMEs: MENG, ELLIS  (contact)

PROGRAM_OFFICER_NAME: HUDAK, ERIC MICHAEL

PROJECT_TERMS: Address;Administrator;Advisory Committees;Algorithms;artificial neural network;autonomic nerve;bioelectronics;career;Chronic;Collaborations;collaborative approach;Communication;Communities;Computer software;computerized data processing;Constipation;Data;Development;Documentation;Ensure;Event;Galaxy;Gender;Goals;Hour;Implant;implanted sensor;Individual;Industry;Institution;interest;interoperability;Lead;Leadership;Licensing;LinkedIn;Medicine;meetings;member;Network-based;Newsletter;online repository;open source;Patients;Physiologic pulse;Postdoctoral Fellow;programs;Reporting;Research Personnel;Resources;Running;signal processing;Site;social media;Software Engineering;Specific qualifier value;symposium;System;Systems Integration;Technology;technology platform;Testing;Training;Training Activity;United States National Institutes of Health;Update;user-friendly;Vision;wearable data;web site;wiki;Work

PROJECT_TITLE: HORNET  Center for Autonomic Nerve Recording and Stimulation Systems (CARSS)


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurosciences;Patient Safety;Stroke

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Ally;Architecture;Aspiration Pneumonia;autonomic nerve;Autonomic nervous system disorders;Biocontrols;bioelectronics;Clinical;cost;Custom;Deglutition Disorders;design;Diameter;Elasticity;Electrodes;Equilibrium;fabrication;Film;flexibility;Foreign Bodies;Health;Hypertension;Immune response;Implant;Individual;Inflammatory Bowel Diseases;instrument;interest;Lead;manufacture;manufacturing technology;Measures;Medical;Medicine;Memory;Metals;Methods;Microfabrication;miniaturize;minimally invasive;Molds;Nerve;Nerve Fibers;neural;Non-Insulin-Dependent Diabetes Mellitus;novel;open source;Operative Surgical Procedures;parylene;parylene C;Perineuriums;Peripheral;Peripheral Nerves;Peripheral Nervous System;polydimethylsiloxane;Polymers;post stroke;preservation;Process;Recording of previous events;Research;Rheumatoid Arthritis;Scheme;Shapes;Site;Structure;Surgical sutures;System;Testing;Thick;Thinness;tool;Welding;wound


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Obesity;Pediatric;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE: Obesity is presenting earlier in life than ever before and carries with it an increased risk of other chronic conditions that have a major impact on everyday life. This research will examine the biological risk factors of obesity in infancy and early life in underrepresented minority populations and how behavior/environment (e.g., diet, sleep, socioeconomic position) alters that risk. This knowledge is relevant to public health because a better understanding of childhood obesity risk that may be compounded by behavior and environment will help us more effectively prevent obesity in childhood and improve health across the lifespan.

PI_NAMEs: HEINSBERG, LACEY W (contact)

PROGRAM_OFFICER_NAME: WALKER, JENELLE ROSE

PROJECT_TERMS: Address;Adult;Age;Alleles;American Samoa;Amino Acids;Beginning of Life;Behavior;Behavioral;Biochemical;Biological;Birth;Blood;Body Composition;Body mass index;Body Size;bone;Bone Density;bone mass;Carbon;cardiometabolism;career development;Cell model;Cessation of life;Child;Childhood;Chronic;Clinical;cohort;Cohort Studies;Communities;Competence;Complex;CREB3 gene;Data;Data Analyses;Data Collection;Dedications;design;Development;Diabetes Mellitus;Diet;Disease;Dryness;Dual-Energy X-Ray Absorptiometry;Environment;Environmental Risk Factor;ethnic diversity;Etiology;experience;Fatty acid glycerol esters;Foundations;Future;Genetic;Genetic Variation;Genomics;Genotype;Geography;Gestational Diabetes;Goals;Growth;Health;health equity;high risk;high risk population;improved;infancy;Infant;insight;Intervention;Knowledge;Life;life span;Lipids;Maternal and Child Health;Measures;Mentors;Mentorship;Metabolic;Metabolic Pathway;metabolomics;Methodology;Methods;Minor;Minority Groups;Mothers;Mus;Nonesterified Fatty Acids;nutrition;Obesity;Obesity associated disease;obesity in children;obesity prevention;obesity risk;Pacific Islander;Participant;Pathway interactions;Phase;Phenotype;phenotypic data;Population;Pre-Clinical Model;precision medicine;premature;prenatal;prevent;programs;Public Health;Quality of life;racial diversity;Research;Research Personnel;Resources;Risk;Risk Factors;risk variant;Role;Samoa;Samoan;Sampling;Sleep;Socioeconomic Status;Spottings;Symptoms;Thinness;Time;Training;Translating;Umbilical Cord Blood;Underrepresented Minority;Underrepresented Populations;Variant;Weight;Work

PROJECT_TITLE: CREBRF Genomics, Gestational Diabetes, and Early Life Body Size in American Samoa

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: Boulder

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF COLORADO

PHR: PROJECT NARRATIVE Public Health Significance: Results from this project will facilitate an improved understanding of the genetic and neurobiological factors involved in smoking behavior. Such knowledge should lead to the development of improved strategies for prevention and treatment of individuals who suffer from nicotine addiction.

PI_NAMEs: EHRINGER, MARISSA A (contact);HOEFFER, CHARLES A;STITZEL, JERRY A

PROJECT_TERMS: Abstinence;Acute;Address;Affect;Animal Model;Animal Testing;Animals;Antisense Oligonucleotide Therapy;Anxiety;Astrocytes;Behavior;Behavior assessment;behavioral response;Biochemical;Biochemical Markers;Biological;Biological Assay;Body Temperature;Brain;brain cell;Brain region;Candidate Disease Gene;Cell Culture Techniques;Chronic;conditional knockout;conditioned place preference;Data;Development;differential expression;drug of abuse;druggable target;effective therapy;electronic cigarette use;Event;Excision;Exhibits;Family;Future;Gene Expression Profile;Gene Modified;gene network;Generations;Genes;Genetic;Genetic Transcription;genome wide association study;genome-wide;Genotype;Health;Heart Rate;Histologic;Human;Human Genome;improved;In Vitro;in vivo;in vivo Model;Individual;innovation;insight;Intake;interest;knock-down;Knockout Mice;Knowledge;Laboratories;Learning;Measures;Modeling;Morphology;Motivation;Motor Activity;mouse model;Mouse Strains;Mus;neural;Neurobiology;Neurons;Nicotine;Nicotine Dependence;nicotine exposure;nicotine treatment;nicotine use;Nicotine Withdrawal;Nicotinic Receptors;novel;Pathway Analysis;Pathway interactions;Phase;Phenotype;Prevention strategy;Public Health;Publishing;Reagent;Research;response;Rewards;RiboTag;RNA;Role;Sex Differences;Signal Transduction;Site;Sleep;Small Interfering RNA;Smoking;Smoking Behavior;smoking cessation;smoking relapse;Smoking treatment;Societies;Specificity;Substance abuse problem;Technology;Testing;Tobacco;Tobacco use;transcriptome;transcriptomics;Translating;United States;Variant;Vendor;Withdrawal;Withdrawal Symptom;Woman

PROJECT_TITLE: Role of glial expression in nicotine behaviors for genes identified through human GWAS


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Genetics;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Preterm birth is the leading cause of infant morbidity and mortality throughout the world. Intrauterine infection and/or inflammation is a major trigger of early labor leading to preterm birth. The goal of this project is to identify novel therapeutic agents to manage infection-induced inflammation leading to preterm labor and protect against fetal inflammation without adverse side effects to the fetus.

PI_NAMEs: SIRICILLA, SHAJILA  (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: 37 weeks gestation;Academic Medical Centers;Adverse effects;Advisory Committees;Affect;Agonist;Amniotic Fluid;Antibiotics;Bacteria;Biological Assay;Biology;Birth;career development;Chemicals;Circulation;Clinical;Communicable Diseases;Continuing Education;Custom;cytokine;cytotoxicity;Decidua;Development;Discipline of obstetrics;Dose;Drug Combinations;drug discovery;Drug Targeting;druggable target;early pregnancy;Educational workshop;Ensure;Escherichia coli;experience;Exposure to;fetal;fetal inflammatory response syndrome;Fetal Tissues;Fetus;Future;Gene Targeting;Genes;Genome;global health;Goals;Grant;Hematogenous;high throughput screening;Human;IL6 gene;in utero;In Vitro;in vivo;Indomethacin;infant morbidity;infant morbidity/mortality;Infant Mortality;Infection;infection management;Infection prevention;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;Innate Immune System;interest;Intervention;intraamniotic infection;intrapartum;intrauterine infection;intrauterine inflammation;Invaded;Lead;Libraries;Measurement;Measures;Mediating;Membrane;Mentors;Mentorship;microbial;microorganism;Modeling;Molecular;Molecular Bank;Monitor;Morbidity - disease rate;mouse model;multidisciplinary;Mus;neonatal morbidity;neonatal outcome;Neonatology;Non-Steroidal Anti-Inflammatory Agents;novel;novel strategies;novel therapeutics;pathogen;Pathologic;Pathway interactions;Pattern;Pharmacology;Phase;Phenotype;Physiology;Pregnancy;Premature Birth;Premature Labor;prenatal exposure;Primates;programs;Reaction;Records;Regulation;Reproducibility;Reproductive Sciences;Research;Research Personnel;Resources;responsible research conduct;Route;screening;Series;side effect;Signal Pathway;small molecule;small molecule inhibitor;small molecule libraries;Stimulus;Streptococcus Group B;Structure;success;symposium;Testing;Therapeutic;Therapeutic Agents;therapeutic effectiveness;therapeutically effective;Tissue Model;Tissues;Training;transcriptome;transcriptomics;Treatment Efficacy;Ureaplasma urealyticum;Vagina;Work;Writing

PROJECT_TITLE: Discovery of Novel Therapeutics for Inflammation Induced Preterm Birth


NIH_SPENDING_CATS: Cancer;Clinical Research;Complementary and Integrative Health;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Narrative Pancreatic ductal adenocarcinoma (PDA) is a deadly cancer for which there are few effective treatment options. Multiple targetable pathways in cancer show circadian rhythmicity in a tumor specific manner. Therefore, the time of treatment (chronotherapy) can influence the efficacy of therapies in PDA. To advance more targeted, personalized circadian medicine approaches for PDA patients there is a critical need to gain knowledge of normal pancreatic rhythms and identify tumor specific rhythms and markers to guide chronotherapy. We propose to develop and optimize new pre-clinical protocols using normal pancreas and patent derived organoid cultures to inform the way treatment decisions are made within the context of PDA.

PI_NAMEs: BISHEHSARI, FARAZ  (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Area;Bioinformatics;Biological Assay;Biological Markers;Biological Process;Biopsy;Cancer Etiology;cancer subtypes;cancer type;Cell Line;Cessation of life;chemotherapy;Chronotherapy;circadian;circadian pacemaker;Circadian Rhythms;Clinic;Clinical;clinical application;Clinical Research;Clinical Trials;Code;Colon Carcinoma;Data;Data Science;Decision Making;Detection;Development;Diagnosis;Disease;disease prognosis;Disseminated Malignant Neoplasm;DNA biosynthesis;DNA Repair;Dose;drug efficacy;effective therapy;Effectiveness;Endoscopic Biopsy;Event;Excision;fighting;Genes;Goals;Heterogeneity;high reward;high risk;Hour;Human;improved;Incidence;Individual;Individuation;innovation;insight;inter-individual variation;interest;Knowledge;Learning;Link;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Medicine;Methods;Molecular;Molecular Abnormality;Molecular Profiling;Motivation;next generation sequencing;novel;novel therapeutic intervention;Operative Surgical Procedures;Organ;Organoids;Outcome;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathologic;Pathway interactions;Patients;Pattern;Periodicity;personalized approach;personalized medicine;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;pre-clinical;precision medicine;Precision therapeutics;preclinical study;Prognosis;Proteins;Protocols documentation;Randomized;Research;response;Retroperitoneal Space;Role;Sampling;screening;Shapes;side effect;Solid Neoplasm;Source;standard of care;Technology;Testing;Therapeutic;therapeutic target;Therapeutic Uses;Time;Tissues;transcriptomics;Treatment Efficacy;treatment strategy;tumor;Tumor Tissue;Variant;Work

PROJECT_TITLE: Development of a precision medicine platform for circadian based therapeutics in pancreatic cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]