NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Social Determinants of Health;Telehealth

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Persons living with dementia often also live multiple chronic conditions which necessitate complex care regimens, but as functional impairment worsens, persons living with dementia may struggle to leave home to access medical care. Home-based medical care and telemedicine then become instrumental in enabling continuity of patient care, tailoring medical management to evolving patient needs and risks, and mitigating caregiving burden for community living persons living with dementia. Using national Medicare administrative data, the proposed study aims to examine the use of home-based medical care among persons living with dementia with private and public Medicare, its change following the 2020 expansion of telemedicine and their overall impact on patient outcomes and disparities.

PI_NAMEs: HANCHATE, AMRESH D (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Acute;acute care;Aging;Alzheimer's disease related dementia;Area;care giving burden;care providers;Caregiver Burden;Caring;Cessation of life;community living;Complex;Continuity of Patient Care;COVID-19 outbreak;Data;Dementia;deprivation;Development;Disparity;Enrollment;Equity;Ethnic Origin;Experimental Models;Fee-for-Service Plans;Functional impairment;Health;health care service utilization;health difference;Healthcare;Home;Home visitation;hospice environment;improved;Income;indexing;Long-Term Care;Measures;Medical;Medicare;multiple chronic conditions;older adult;Outcome;Outpatients;Patient-Focused Outcomes;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Physicians;Policies;Population;Privatization;Provider;public health emergency;Quasi-experiment;Race;Regimen;Risk;Role;Services;sex;socioeconomics;Subgroup;Telemedicine;Transportation;trend;Validation;virtual;Visit;Work

PROJECT_TITLE: Role of Home-based Medical Care and Telemedicine in Care and Outcomes of Dementia and Coexisting Conditions in Public and Private Medicare


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative  Approximately 40% of myeloproliferative neoplasms (MPNs) are driven by mutations in the gene calreticulin (CALR), which are classified as either type 1 or type 2. Both type 1 and type 2 CALR mutations have identical mutant C-termini, but for reasons that remain unknown, they engender distinct disease phenotypes with significant prognostic differences. Based on our recent finding that type 1 and 2 CALR mutations activate different arms of an ancient cellular stress response pathway called the unfolded protein response (UPR), we propose to test the hypothesis that differential UPR activation leads to the divergent clinical phenotypes seen in type 1 versus type 2 CALR patients, and that these pathways can be uniquely targeted for therapeutic gain in type 1 versus type 2 CALR-driven MPNs.

PI_NAMEs: ELF, SHANNON ELISABETH (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Acute Myelocytic Leukemia;Anabolism;arm;ATF6 gene;Base Pairing;Binding;Binding Sites;Blood Platelets;Bone Marrow;Bone remodeling;C-terminal;Calcium Binding;calreticulin;cancer cell;Carbon;Cell Compartmentation;Cell Death;Cell Survival;Cells;Cellular Stress;Classification;clinical phenotype;Code;Collagen;curative treatments;cytokine;Data;Deposition;Development;Disease;disease phenotype;Disease Progression;driver mutation;Endoplasmic Reticulum;endoplasmic reticulum stress;Erythrocytes;Etiology;Exhibits;Exons;Fibrosis;Functional disorder;Genes;Glycine;granulocyte;Hematocrit procedure;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hemoglobin;Hemorrhagic Thrombocythemia;In Vitro;in vivo;Incidence;individualized medicine;Inflammation;Inflammatory;inhibitor;Interleukin-6;JAK2 gene;Lead;loss of function;Mediating;Megakaryocyte Proliferation;Megakaryocytes;Metabolism;Molecular;Molecular Abnormality;Molecular Chaperones;Morbidity - disease rate;mortality;MPL gene;mutant;Mutation;Myeloid Cells;Myeloproliferative disease;Neoplasms;novel;Pathogenicity;Pathway interactions;Patients;Peptides;Phenotype;Polycythemia Vera;Primary Myelofibrosis;Production;Prognosis;prognostic;Proteins;proteostasis;response;Risk;Role;sensor;Serine;Signal Transduction;Somatic Mutation;stem cells;stressor;Stromal Cells;Survival Rate;targeted treatment;Testing;therapeutic target;transcription factor;treatment strategy;Up-Regulation;XBP1 gene

PROJECT_TITLE: The Pathophysiology of Type 1 Versus Type 2 Mutant Calreticulin-Drivenmyeloproliferative Neoplasms

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Neurosciences;Rehabilitation;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PI_NAMEs: WOLFE, TATIANA  (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Adult;Affect;Anisotropy;Area;Bilateral;Brain;brain health;Breast;Breast Cancer Patient;Breast Cancer survivor;Breast Cancer therapy;cancer therapy;chemobrain;chemotherapy;cingulate cortex;cingulate gyrus;Clinical;Cognition;Cognitive;Cognitive deficits;cognitive function;Creatine;daily functioning;Development;Diffusion;Doxorubicin;executive function;Functional disorder;functional restoration;Future;Health;Immune response;Impaired cognition;Intervention;Knowledge;Learning;Longitudinal Studies;Measures;Memory;molecular marker;Myelin;myelination;N-acetylaspartate;Nature;Neurocognitive;neuronal metabolism;Neuronal Plasticity;Patients;Play;Preventive;regenerative;Reporting;Research;Rest;Role;Speed;Survivors;Synapses;thalamocortical tract;treatment effect;white matter

PROJECT_TITLE: Myelin mechanisms of brain synaptic dysfunction in breast cancer therapy survivors


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Services;Prevention;Women's Health Research

PI_NAMEs: PARKER, PEARMAN  (contact)

PROJECT_TERMS: Age;Body Image;Breast Cancer survivor;Breast Cancer therapy;Breast Cancer Treatment;Cancer Center;cancer therapy;chemotherapy;Clinical;Effectiveness;efficacy evaluation;Emotional;empowerment;Enrollment;Estrogens;experience;Face;Goals;health communication;Health education;Hydration status;Immune response;improved;Incidence;innovation;Intervention;Malignant Breast Neoplasm;Malignant Neoplasms;Menopausal Symptom;Mind-Body Intervention;mind/body;Nurses;Oncology;Operative Surgical Procedures;Participant;Pharmaceutical Preparations;pilot trial;Privatization;programs;Protocols documentation;Provider;psychoeducational intervention;Quality of life;Radiation;Randomized;recruit;Research;satisfaction;Sex Functioning;Sexual Health;side effect;Survival Rate;survivorship;Vagina;Waiting Lists;Woman;young woman

PROJECT_TITLE: Impact of a nurse-led mind-body intervention on sexual health in breast cancer


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_STATE: NC

PHR: Overall Narrative Childhood cancers, though rare, significantly impact thousands of children globally each year, necessitating extensive research to understand their underlying mechanisms. This P30 supplement project aims to establish a federated learning (FL) framework to securely integrate and analyze diverse datasets from multiple institutions, enhancing our understanding and treatment of neuroblastoma and pediatric CNS tumors.

PI_NAMEs: MESA, RUBEN A. (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Affect;anti-cancer research;Area;Behavior;Biological;Biological Markers;Brain;cancer type;Central Nervous System Neoplasms;Characteristics;Child;Childhood;Childhood Brain Neoplasm;Childhood Central Nervous System Neoplasm;Clinical;Clinical Data;Clinical Trials;Cognition;cohort;Collaborations;Data;data modeling;Data Pooling;Data Security;Data Set;Decision Making;demographics;Diagnostic;distributed data;diverse data;DL-alpha-Difluoromethylornithine;DNA Sequence Alteration;Ensure;Esthesia;federated learning;Generations;Genetic;Genetic Transcription;Genomics;Glioma;Goals;Healthcare;high risk;Hospitals;Image;improved;Individual;insight;Institution;Location;Machine Learning;machine learning algorithm;machine learning method;Malignant Childhood Neoplasm;Malignant Neoplasms;Medulloblastoma;Methods;Modeling;Movement;multimodal data;multimodality;multiple datasets;MYCN gene;Neuroblastoma;novel;novel strategies;Organ;patient privacy;Patient-Focused Outcomes;Patients;Positioning Attribute;privacy preservation;Prognosis;radiological imaging;Recording of previous events;Research;Research Personnel;Sarcoma;Secure;Security;sex;Site;Solid Neoplasm;Spinal Cord;Structure;Survival Analysis;survival prediction;Symptoms;Testing;therapeutic target;Training;transcriptomics;Treatment Protocols;tumor

PROJECT_TITLE: Federated Learning Framework for Multimodal Survival Analysis in Pediatric Cancers


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Pediatric

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative Developmental Language Disorder affects approximately seven percent of the population and is characterized by grammatical deficits that cascade into lifelong academic challenges and under-employment. Current treatments for DLD produce good outcomes under ideal, high intensity conditions or when parents have been trained to deliver therapy using intense coaching methods; however, current publicly funded service delivery systems and private-pay reimbursement models do not support treatment being delivered in this ideal fashion for children older than three. This project will examine alternative methods of delivering treatment that may be more feasible under typical conditions and will identify implementation barriers, with the goal of improving long- term outcomes for children with DLD.

PI_NAMEs: VAN HORNE, AMANDA JEAN OWEN (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Adherence;Adopted;Adoption;Adult;Advocate;Affect;Age;alternative treatment;Behavior;Books;caregiver education;Caregivers;Characteristics;Child;Childhood;comparative efficacy;Complex;Comprehension;comprehension deficit;cost;Data;design;Development;Disease;Dose;Educational Curriculum;Effectiveness;Enrollment;Equation;Exposure to;Feedback;Funding;Future;Goals;Home;implementation barriers;improved;Individual;interactive feedback;Intervention;Knowledge;Laboratories;Language Development;Language Development Disorders;Laws;Learning;Learning Difficulty;literacy;Methods;Modeling;Nature;Outcome;parenting intervention;Parents;Pattern;Population;Privatization;Production;Provider;Quality of life;Randomized, Controlled Trials;Reader;Reading;Recommendation;remediation;Reporting;Risk;Role;scale up;School-Age Population;service delivery;Service delivery model;Service provision;skills;Speech;Speech Pathologist;standard of care;Structure;success;syntax;System;Techniques;Theoretical Domains framework;Training;Underemployment;visual tracking;Width;Work

PROJECT_TITLE: Recasting and book reading under ideal (dose-controlled) and typical (dose-variable) conditions: The role of fidelity and adherence in production and comprehension outcomes for children with DLD

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Hearing Loss;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Narrative During the critical search for drugs to treat COVID-19 patients, it’s important to select drugs with maximum antiviral efficacy and minimal side-effects. Using a combination of computer modeling and animal studies, we will test the potential for COVID-19 therapies to cause hearing loss; a side-effect of many drugs not often detected during clinical trials. Our goal is to help develop safer COVID-19 therapies.

PI_NAMEs: COFFIN, ALLISON B (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Adult;Animals;anti-viral efficacy;Auditory;Azithromycin;Biological Assay;Biometry;Blood;Case Study;Categories;Cause of Death;Chemical Structure;Clinical;Clinical Trials;Cochlea;combat;Computer Models;computer scientist;cost;COVID-19;COVID-19 patient;COVID-19 screening;COVID-19 therapeutics;COVID-19 treatment;cytotoxic;cytotoxicity;Data;Data Set;Databases;Detection;Development;Disease;drug candidate;Drug Combinations;drug development;Drug usage;experimental study;FDA approved;feature selection;Goals;Hair Cells;hearing impairment;Hearing Tests;Human;Human Resources;Hydroxychloroquine;Immune response;Immune system;in silico;In Vitro;in vivo;Individual;Infection;Inner Hair Cells;innovation;Intervention;Ivermectin;Labyrinth;lateral line;Life;Link;Machine Learning;machine learning model;Methods;Modeling;Molecular;Monitor;Morphology;novel;novel therapeutics;older patient;Organ;otoprotectant;ototoxicity;ototoxin;pandemic disease;Patient Monitoring;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Physiological;Physiology;Positioning Attribute;pre-clinical;Preclinical Testing;preservation;Principal Component Analysis;Public Health;Publishing;rapid detection;Rattus;Reporting;Research;research clinical testing;response;Risk;Ritonavir;screening;Sensory;Sensory Hair;severe COVID-19;side effect;Stavudine;Supporting Cell;Synapses;System;systemic inflammatory response;Testing;Therapeutic;Therapeutic Uses;Toxic effect;training data;Treatment Efficacy;Vaccination;Work;Zebrafish

PROJECT_TITLE: Determining the ototoxic potential of COVID-19 therapeutics using machine learning and in vivo approaches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-B(02)M]


ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

ORG_STATE: CA

PHR: RELEVANCE – Parent Grant COVID-19 is one of the greatest threats to mankind and has caused substantial mortality, morbidity and huge economic losses. There seems to be no clear path as to when this pandemic will end, as vaccines and new therapeutics may take several months or years to come to fruition. Despite the importance of tissue-resident memory T cells in the control of viral infections and providing immunity against future infection, we do not know if SARS-CoV-2 infection generates TRM responses at the sites of infection. Here, we will employ cutting-edge single-cell RNA-seq assays to characterize properties of SARS-CoV-2 reactive TRM cells in airway/lung and tumor tissues from cancer and non-cancer patients with or without previous SARS-CoV-2 infection.

PI_NAMEs: AY, FERHAT ;OTTENSMEIER, CHRISTIAN HERMANN HEINRICH;VIJAYANAND, PANDURANGAN  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: 2019-nCoV;anti-PD1 therapy;anti-tumor immune response;Antibody Response;Automobile Driving;B-Lymphocytes;Bioinformatics;Biological Assay;cancer cell;Cancer Research Project;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Immunity;cellular targeting;Clinical;cohort;Collaborations;COVID-19;COVID-19 pandemic;COVID-19 patient;cross reactivity;Cytomegalovirus;DNA Viruses;Economics;experience;Frequencies;Future;human coronavirus;Human Herpesvirus 4;Human Papillomavirus;Immunity;Immunology;Individual;Infection;Influenza;Larynx;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Morbidity - disease rate;mortality;Mucous Membrane;Nose;novel therapeutics;Operative Surgical Procedures;Oropharyngeal;pandemic disease;parent grant;Patients;Peptides;Peripheral Blood Mononuclear Cell;post SARS-CoV-2 infection;Property;respiratory;response;RNA Viruses;SARS-CoV-2 infection;Science;Serology;single cell genomics;single-cell RNA sequencing;Site;Specimen;Structure of parenchyma of lung;T cell receptor repertoire sequencing;T-Lymphocyte;Time;tissue resident memory T cell;transcriptomics;tumor;tumor immunology;Tumor Tissue;Vaccines;Viral;Virus;Virus Diseases;Writing

PROJECT_TITLE: SARS-CoV-2-reactive tissue-resident memory T cells in healthy and cancer subjects


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE The Yale Head and Neck SPORE is a team of clinical and laboratory researchers studying the problem of treatment resistance in head and neck cancer. Each of three projects brings a basic and clinical research leader together to study ways to overcome resistance to common therapies, such as cetuximab and cisplatin, as well as to find ways to make HPV-driven cancers more sensitive to immunotherapy. There are clinical trials to treat patients with HPV-negative and HPV-driven cancer before they go to surgery. The projects are supported by core facilities to provide administrative, pathology and statistical support, and there are funds to support new projects and new investigators.

PI_NAMEs: BURTNESS, BARBARA  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Address;Animals;apolipoprotein B mRNA editing enzyme;aurora kinase A;barrier to care;Basic Science;Bioinformatics;Biometry;Cancer Biology;Cancer Center;career;Cell Line;Cells;Cellular biology;Cessation of life;Cetuximab;checkpoint inhibition;Cisplatin;Clinic;Clinical;Clinical Research;Clinical Trials;Collaborations;Combined Modality Therapy;Communities;conventional therapy;Core Facility;Correlative Study;curative treatments;Data;demethylating therapy;demethylation;Development;Disease;DNA Damage;EGFR inhibition;Epidermal Growth Factor Receptor;ERBB3 gene;Family;Family member;Fostering;Foundations;Fox Chase Cancer Center;Functional impairment;Funding;Future;Generations;Genes;Genomics;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;HPV negative;HPV-negative head and neck cancer;Human;Human Papillomavirus;Immune;Immune response;Immunology;Immunotherapy;improved;inhibitor;insight;Institution;Laboratories;Link;Malignant Neoplasms;Mediating;Mentors;Methodology;Modality;Modeling;Molecular Abnormality;Molecular Conformation;mortality;Mutation;new therapeutic target;next generation;North Carolina;novel;novel strategies;Operative Surgical Procedures;oral HPV-positive head and neck cancers;Outcome;overtreatment;Pain;Pathology;Patients;Pharmacodynamics;Pharmacology;polypeptide;programs;Proteins;Radiation;Radiobiology;Recurrence;Reproduction spores;Research;Research Personnel;Resistance;Resources;response;Role;Safety;Sampling;Scientist;Signal Transduction;Specimen;structural biology;System;targeted treatment;therapy resistant;TP53 gene;Training;Translational Research;translational scientist;Translations;treatment response;tumor;United States;Universities;Validation;virology;Yale Cancer Center

PROJECT_TITLE: Yale Head and Neck Cancer SPORE: Overcoming Treatment Resistance in Head and Neck Cancer


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: DURHAM

PI_NAMEs: SIRIGIRI, RENUKA  (contact)

PROJECT_TERMS: Dialysis procedure;Ensure;high volume manufacturing;in vitro testing;Individual;Injections;Knowledge;manufacture;Marketing;Medical Device;Molds;nasopharyngeal swab;Process;RADx Tech;seal;Sterilization;supply chain;Swab

PROJECT_TITLE: RAPID ACCELERATION OF DIAGNOSTICS (RADX) TECH PROJECT NO. 7453: HIGH VOLUME INJECTION MOLDED SWAB


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PI_NAMEs: FRENCK, ROBERT  (contact)

PROJECT_TERMS: Area;Biological;Biological Assay;Biological Products;Bioterrorism;Clinical;Communicable Diseases;Contracts;Development;Educational workshop;efficacy testing;Emerging Communicable Diseases;Evaluation;evaluation/testing;Feasibility Studies;immunogenicity;Immunology procedure;Investigational New Drug Application;Licensing;novel vaccines;Office of Administrative Management;operation;product development;protocol development;Qualifying;Reporting;Safety;Sampling;Services;Site Visit;Testing;testing services;Toxicology;Training;vaccine candidate;vaccine development;Vaccines;Validation

PROJECT_TITLE: Vaccine and Treatment Evaluation Units (VTEU): Task for Overall Administration, Clinical Operations Support, Protocol Development, Implementation and Assays


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Neurosciences

ORG_CITY: FLEMINGTON

ORG_STATE: NJ

PHR: Subject matter expert support for developing therapies for neurological disorders

PI_NAMEs: MINOR, LISA  (contact)

PROJECT_TERMS: Address;assay development;Biochemical;Biological Assay;Cells;Clinical;Clinical Research;Collaborations;Consultations;Contractor;design;Development;drug development;experimental study;in vitro Assay;Individual;lead optimization;Logistics;Nervous System Disorder;Pharmaceutical Chemistry;pre-clinical;programs;Recommendation;Resources;Role;Services;small molecule;Strategic Planning;therapy development;United States National Institutes of Health;Validation

PROJECT_TITLE: BIOACTIVITY ASSAY DEVELOPMENT CONSULTANT SUPPORT SERVICES


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PI_NAMEs: COLER, RHEA  (contact)

PROJECT_TERMS: Animals;design;Goals;HIV;Human;Immune;Immune Evasion;Immune response;Immune Targeting;Immunologics;improved;multidisciplinary;Mycobacterium Infections;Mycobacterium tuberculosis;non-tuberculosis mycobacteria;nonhuman primate;programs;Research Activity;Research Personnel;response;SIV;Tissues;Tuberculosis;Tuberculosis Vaccines;vaccine strategy

PROJECT_TITLE: Immune Mechanisms of Protection Against Mycobacterium Tuberculosis Center (IMPAC-TB)


ORG_CITY: Rockville

ORG_NAME: DIGITAL INFUZION, INC.

ORG_STATE: MD

PI_NAMEs: BOUR, STEPHAN  (contact)

PROJECT_TERMS: Address;Award;Clinical and Translational Science Awards;cohesion;Collaborations;Communication;Contractor;Contracts;Credentialing;data to knowledge;Ensure;experience;Grant;innovation;Institution;Knowledge;Mission;National Center for Advancing Translational Sciences;novel strategies;operation;Patients;process repeatability;programs;Research;Resources;Structure;Technology;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: NCATS CLINICAL AND TRANSLATIONAL SCIENCE AWARDS (CTSA) PROGRAM: COORDINATION, COMMUNICATION AND OPERATIONS SUPPORT (CCOS)


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: SILVERA, PETER  (contact)

PROJECT_TERMS: AIDS prevention;archive data;Biological;Biological Assay;Cells;co-infection;Collaborations;Communities;Contraceptive Agents;Contractor;Contracts;data archive;Development;Devices;Equipment and supply inventories;Extramural Activities;Formulation;HIV;Investigator-Initiated Research;Liquid substance;National Institute of Allergy and Infectious Disease;novel therapeutics;pathogen;Pediatrics;pre-clinical;Prevention;Private Sector;product development;Reagent;Research;research clinical testing;research study;Resources;Science;Services;Shipping;SIV;Specimen;therapeutic development;Tissues

PROJECT_TITLE: Resources to Advance Pediatrics and HIV Prevention Science: Scientific and Quality/Regulatory Support Services


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Services;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Women with gestational diabetes mellitus (GDM), a common pregnancy complication, face elevated risk for later developing type 2 diabetes. Health professionals recommend that women with GDM be screened for diabetes after delivery and participate in lifestyle programs to help prevent type 2 diabetes; however, most women do not receive these services. This study will develop an outreach strategy to help maximize the number of women with GDM who take advantage of health services for type 2 diabetes prevention.

PI_NAMEs: BROWN, SUSAN DENISE (contact);FERRARA, ASSIAMIRA

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Affect;Body Weight;California;Caring;Chronic;Clinical;clinical risk;Cluster randomized trial;Communities;comparative effectiveness;Complication;cost;Cost Sharing;Data;Decision Making;design;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;diabetes risk;Diagnosis;discount;Early treatment;Electronic Health Record;empowerment;Enrollment;ethnic diversity;evidence base;Face;fasting plasma glucose;feasibility testing;Fostering;Fright;Future;Gestational Diabetes;Glycosylated hemoglobin A;Goals;Guidelines;Health;health assessment;Health Professional;Health Services;Health system;Healthcare;high risk;Hour;Infrastructure;innovation;interest;Intervention;Life Style;Link;Mediator;Medical;Methods;Minority;Modeling;Motivation;motivational enhancement therapy;multiphase optimization strategy;neglect;Non-Insulin-Dependent Diabetes Mellitus;novel;OGTT;online delivery;Outcome;outreach;Pathway interactions;Patient Outcomes Assessments;Patients;Perinatal Care;Phase;Population;postpartum care;Postpartum Period;pragmatic trial;Pregnancy;Pregnancy Complications;Prenatal care;prevent;Prevention;Preventive;Preventive care;primary outcome;Problem Solving;programs;Provider;psychologic;racial diversity;Randomized;randomized trial;Recommendation;Reporting;Risk;Sampling;screening;Screening Result;secondary outcome;Secure;Self Care;Self Direction;Self Efficacy;Services;Surveys;Testing;theories;therapy development;Time;uptake;Visit;Weight;Woman;Work

PROJECT_TITLE: Optimizing a scalable intervention to maximize guideline-recommended diabetes testing after GDM

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;HIV/AIDS;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Particle biogenesis and assembly are necessary steps of both cell-free and cell-to-cell transmission of infectious human retroviruses, including transmission events occurring at mucosal surfaces in the oral cavity. However, viral and cellular protein determinants that are critical for cell-to-cell transmission are not fully understood. A greater understanding of viral proteins, and interactions with host cellular proteins, will help address a notable knowledge gap in the field, which will help inform the development of novel therapeutics to decrease viral transmission at mucosal surfaces.

PI_NAMEs: WILLKOMM, NORA  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Actins;Address;Appearance;Biogenesis;Biological;casein kinase;Cell Communication;Cell membrane;Cells;Child;Communities;comparative;Consumption;cryogenics;Cytoplasm;Cytoskeleton;Development;effective therapy;Electron Microscopy;Event;experimental study;Fluorescence;fluorescence imaging;Fluorescence Microscopy;gag Gene Products;Generations;Genetic Materials;HIV-1;Human;Human Milk;Human T-Cell Leukemia Viruses;Human T-lymphotropic virus 1;imaging approach;Imaging Techniques;Individual;Infection;innovative technologies;insight;Investigation;Knowledge;light microscopy;Location;Modification;Molecular;Molecular Virology;Mothers;Mucous Membrane;Nature;Neurons;new technology;novel therapeutic intervention;novel therapeutics;Oral;oral biology;Oral cavity;Oral mucous membrane structure;particle;Pathway interactions;Patients;permissiveness;Pharmaceutical Preparations;Play;polarized cell;postnatal;Prevention;Process;Productivity;Protein Kinase C;Proteins;Recording of previous events;recruit;Reporting;Research;Research Personnel;Retroviridae;Role;Site;Source;Structural Protein;Surface;Testing;transmission process;Ubiquitin;Vertical Disease Transmission;Viral;viral pandemic;Viral Proteins;Viral Structural Proteins;viral transmission;Virion;virological synapse;virology;Virus;Virus Assembly;Virus Diseases;Visualization

PROJECT_TITLE: Analysis of human retrovirus particle assembly sites


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Clinical Research

ORG_CITY: NISKAYUNA

ORG_NAME: GE MEDICAL SYSTEMS INFORMATION TECHNOLOGIES, INC

ORG_STATE: NY

PHR: PROJECT NARRATIVE (OVERALL) Our vision for the Skin Tissue Mapping Center (TMC) is to create a first-of-its-kind, comprehensive, 2D and 3D spatially-resolved multi-omic spatial atlas of normal skin comprising cell types, lipidomics, and transcriptomics. Prospective sample collection provides the unique opportunity to custom build a database with more extensive clinical information that may affect skin health. This novel spatial reference map of skin cell types spanning skin tone and location will provide critical new insights into healthy skin characteristics.

PI_NAMEs: FALO, LOUIS D;GINTY, FIONA  (contact);KARUNAMURTHY, ARIVARASAN

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 3-Dimensional;Abdomen;Accounting;Affect;Affinity;African American;Age;age group;Aging;Anatomy;Architecture;Atlases;Automation;Back;Biological Markers;caucasian American;cell type;Cells;Certification;Characteristics;Clinical;Clinical Laboratory Improvement Amendments;Collaborations;Communities;Custom;Data;Data Analyses;data exchange;data integration;Data Set;Databases;Dermatology;Dermatopathology;Diagnostic;Disease;Elderly;ethnic diversity;experience;experimental study;Feedback;Florida;Fluorescence;Fostering;Freezing;Frozen Sections;Generations;Genomics;Goals;Head and neck structure;Health;Human BioMolecular Atlas Program;Image;Immunofluorescence Immunologic;Immunohistochemistry;insight;Laboratories;Lead;Leadership;Limb structure;lipidomics;Location;Maps;member;Morphology;multimodal data;multimodality;multiple omics;multiplexed imaging;nano-string;novel;novel strategies;Outcome;Pathology;Patients;Persons;Phase;Phototherapy;Population;Population Heterogeneity;Process;programs;prospective;Prospective cohort;Publications;quality assurance;Quality Control;Reagent;Recording of previous events;recruit;Reporting;repository;Research;Resolution;Resources;Risk Assessment;sample collection;Sampling;screening;single cell analysis;Skin;Skin Aging;skin color;Skin Tissue;spatial relationship;Specimen;Specimen Handling;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Standardization;technology development;Three-dimensional analysis;tissue fixing;Tissue imaging;tissue mapping;Tissue Sample;tool;transcriptomics;ultraviolet damage;United States National Institutes of Health;Universities;UV Radiation Exposure;Variant;Vision;Visualization;volunteer;working group

PROJECT_TITLE: Multiscale, Multimodal Analysis of Skin and Spatial Cell Organization


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PI_NAMEs: KIMBRO, KEVIN SEAN (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;Advisory Committees;base;Basic Science;Budgets;Clinical;Clinical Research;Collaborations;Communication;Communication Programs;Communities;community engagement;community partnership;community research;COVID-19;COVID-19 pandemic;Data Science;design;Development;Educational workshop;Evaluation Research;Extramural Activities;Fostering;Funding;Funding Opportunities;Goals;Grant;Hand;Health Disparities Research;health disparity;health equity;Health equity research;Institution;Leadership;lectures;Link;Logistics;Maintenance;meetings;Mission;Monitor;Morehouse School of Medicine;multidisciplinary;National Institute on Minority Health and Health Disparities;next generation;Office of Administrative Management;Patients;Pilot Projects;Productivity;programs;Progress Reports;Publications;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;rural area;Rural Community;Rural Health;Schedule;Side;Strategic Planning;Structure;success;symposium;Trainers Training;Translational Research;United States National Institutes of Health;Update;Urban Community;vaccine distribution;Vaccines;Vision;Women's Health

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: FORT WORTH

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: No PHR

PI_NAMEs: AVILLACH, PAUL ;BEECH, BETTINA M.;BORRAYO, EVELINN ;BURGE, LEGAND L.;CARLISLE, ALEX JAMES;CASILLAS, ALEJANDRA ;JONES, HARLAN PIERRE;JUAREZ, PAUL D;MALIN, BRADLEY A.;MANSON, SPERO MARTIN;NORRIS, KEITH C;PURO, JON ;SAMBAMOORTHI, USHA ;SHANKER, ANIL ;SYED, TOUFEEQ AHMED;TAYLOR, HERMAN ALFRED;THORPE, ROLAND J.;VISHWANATHA, JAMBOOR K. (contact)

PROGRAM_OFFICER_NAME: GEBREAB, SAMSON YIKEALO

PROJECT_TITLE: AIM-AHEAD Coordinating Center - All Four Cores


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE  All the cells that compose our bodies arise from a single fertilized ovum and contain the same genomic information, thus during embryonic development the correct genes must be turned on and off in the right cells at the right times to grow and maintain an individual capable of independent life. The work proposed here will integrate cutting edge techniques to directly visualize and quantify how this regulation of gene expression is orchestrated during embryonic development. The critical new information that will be gained from the proposed experiments have the potential to lead to novel therapeutic approaches to prevent or repair defects that arise from aberrant gene expression during development, in aging, and in cancer.

PI_NAMEs: MIR, MUSTAFA AIZED HASAN (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Affect;Aging;Animals;Binding;Binding Proteins;Cell Nucleus;Cells;Chromatin;Data;data integration;Data Set;Defect;Development;Disease;DNA;DNA-Protein Interaction;Drosophila melanogaster;Embryo;Embryonic Development;Environment;Event;experimental study;Fertilization;Foundations;gene correction;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;genetic regulatory protein;Genetic Transcription;genomic locus;Genomics;Glass;Goals;Grant;Health;Hour;imaging approach;Imaging Device;Imaging Techniques;Individual;insight;Interferometry;Kinetics;Knowledge;Label;Life;Light;Malignant Neoplasms;meter;Microscopy;millimeter;molecular imaging;molecular scale;Nature;novel therapeutic intervention;Nuclear;Organism;Population;prevent;Process;Proteins;repaired;Resolution;Role;Sampling;scale up;Shapes;single molecule;Techniques;Technology;Time;Tissue Differentiation;Tissues;transcription factor;Visualization;Work;zygote

PROJECT_TITLE: Quantifying the dynamics of gene regulation and nuclear organization during embryogenesis


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Common imaging phantoms that allow the polarimetric properties of emerging polarization- sensitive optical coherence tomography are needed to support a robust clinical translation of this emerging biomedical imaging technology. The proposed work will optimize and document an imaging phantom addressing this need.

PI_NAMEs: BOUMA, BRETT E (contact)

PROGRAM_OFFICER_NAME: SHABESTARI, BEHROUZ

PROJECT_TERMS: Acceleration;Address;Area;biomedical imaging;Birefringence;Cardiology;Chemistry;clinical translation;Communities;Complex;Consensus;Data Set;Dermatology;design;Detection;Development;Documentation;fabrication;Funding;Image;Imaging Phantoms;imaging study;Imaging technology;Instruction;instrument;instrumentation;Libraries;Light;Measurement;Measures;Methods;Modernization;Modification;National Institute of Biomedical Imaging and Bioengineering;Nerve;Operative Surgical Procedures;Optical Coherence Tomography;Optics;Performance;polarized light;Property;Protocols documentation;Research;Rotation;Signal Transduction;spared nerve;Standardization;System;targeted imaging;Technology;Testing;Translations;Variant;Work

PROJECT_TITLE: Center for Biomedical OCT Research and Translation


NIH_SPENDING_CATS: Biotechnology;Obesity

ORG_CITY: IRVINE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative  Endocrine interactions have been demonstrated as causal and contributory to most common, most notably obesity, type 2 diabetes and resulting cardiovascular complications. The goal of this proposal is to closely bridge computational and experimental methods to systematically dissect mechanisms by which tissues communicate and how these interactions are perturbed in disease settings. Collectively, we will begin with newly developed and unbiased computational approaches which survey population data, validate using high-throughput in vitro assays and evaluate therapeutic potential of new endocrine interactions using mouse models of metabolic disease.

PI_NAMEs: SELDIN, MARCUS MICHAEL (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Address;Bayesian Network;Bioinformatics;bioinformatics pipeline;Cardiovascular system;cell type;Communication;Complex;computerized tools;Data;Disease;disease model;Dissection;Endocrine;Gene Expression;Genetic Variation;Goals;guided inquiry;high throughput screening;Human;in silico;in vitro Assay;in vivo;Individual;insight;Link;Machine Learning;Metabolic Diseases;Metabolism;Methods;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organ;Organism;Pathway interactions;Plasma;Population;population survey;Proteins;Proteomics;Resources;Series;Signal Transduction;Signaling Molecule;success;Surveys;Therapeutic;Tissues;tool;Training;Validation;Variant;Visualization;Work

PROJECT_TITLE: Integrative approaches to dissection of endocrine communication


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: CORE D: NARRATIVE The overall goal of the Program Project is to develop an adaptive learning platform for breast cancer risk prediction and tailored prevention strategies, integrating novel biomarkers of risk. The Patient Centered Outcomes and Cost-Effectiveness Core will be responsible for improving translation of personalized data into breast cancer screening and risk reduction behaviors, creating psycho-educational and motivational tools for patients and providers, improve communication, and integrate patient-centered outcome measures with an enhanced focus on adherence and non-adherence within the Projects.

PI_NAMEs: NAEIM, ARASH  (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: adaptive learning;Address;Adherence;Adoption;Affect;Behavior;Breast Cancer Detection;Breast Cancer Risk Factor;Clinical;Communication;Complement;cost;cost effectiveness;Cost Effectiveness Analysis;Data;Decision Aid;Education;Educational Materials;Endocrine;Ensure;Goals;Guidelines;Healthcare;high risk;High Risk Woman;hormone therapy;improved;Infrastructure;innovation;Intervention;Malignant Breast Neoplasm;Materials Testing;Measurement;Modeling;Motivation;Multimedia;novel marker;novel strategies;Outcome;Outcome Measure;Participant;patient oriented;patient population;Patient-Focused Outcomes;Patients;Perception;personalized screening;polygenic risk score;Prevention;Prevention strategy;Primary Care Physician;programs;Provider;psychoeducation;psychosocial outcome;radiologist;Recommendation;Risk;risk prediction;Risk Reduction;Risk Reduction Behavior;risk stratification;Role;routine screening;screening;Screening for cancer;screening guidelines;Spanish/English;success;tool;Translations;transmission process;tumor;Uninsured Medical Expense;willingness;Woman;women's prevention;Work

PROJECT_TITLE: Core D: Patient Centered Outcomes and Risk Communication

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-T (M1)]


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PI_NAMEs: WYATT, RICHARD THOMAS (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE African trypanosomes are parasites that infect humans and cause the fatal blood-borne disease known as sleeping sickness. Parasite survival and its ability to infect humans depends on two key enzymes that modify the structural organization of DNA, thereby impacting gene regulation of the parasite. Our research will advance our mechanistic understanding of how these critical enzymes control essential biological processes in trypanosomes, potentially leading to the development of inhibitor drugs that can be used to treat and/or cure sleeping sickness and related diseases caused by tropical parasites.

PI_NAMEs: DEBLER, ERIK  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Affect;African;African Trypanosomiasis;Antigenic Variation;Area;Biochemical;Biological;Biological Assay;Biological Process;Biology;Cell Cycle;Cell Cycle Deregulation;Cell Cycle Progression;Cell Cycle Regulation;Cells;Chagas Disease;Chromatin;chromatin protein;combat;Complex;Cryoelectron Microscopy;Data;Defense Mechanisms;Development;Disease;DNA;DNA Binding;DNA biosynthesis;DNA replication fork;drug discovery;effective therapy;Enzymes;Epigenetic Process;epigenetic regulation;Eukaryota;Exhibits;experimental study;Flow Cytometry;fungus;Future;Gene Expression Regulation;Genetic;Genetic Transcription;Genomic DNA;global health;Goals;Histone H3;histone methylation;Histones;Human;Hybrids;Immune system;In Vitro;in vivo;inducible gene expression;inhibitor;inhibitor therapy;insight;interest;Intervention;Kinetoplastida;Knowledge;Leishmania;Leishmaniasis;Life;Lysine;Medical;Methylation;Methyltransferase;Modeling;Modification;Molecular;Monitor;Mutagenesis;mutant;neglected tropical diseases;new therapeutic target;novel;novel strategies;novel therapeutics;Nucleic Acid Regulatory Sequences;Nucleosome Core Particle;Nucleosomes;Organism;overexpression;Parasites;Persons;Pharmaceutical Preparations;pharmacologic;Ploidies;Populations at Risk;posttranscriptional;preference;Process;Protozoa;reconstruction;recruit;Regulation;Research;Resistance;RNA;RNA primers;Roentgen Rays;Role;Signal Pathway;spatiotemporal;structural determinants;Structure;System;Testing;Therapeutic;Transcriptional Regulation;Trees;Trypanosoma;Trypanosoma brucei brucei;Trypanosoma cruzi;Variant;Work;X-Ray Crystallography;Yeasts

PROJECT_TITLE: Chromatin Biology of the African Trypanosome

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Neurosciences

ORG_CITY: LARAMIE

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PI_NAMEs: SHUKLA, RAMMOHAN  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: biological adaptation to stress;Biology;Centers of Research Excellence;Chronic;Down-Regulation;Gene Proteins;Glucocorticoids;Heterogeneity;in vitro Model;in vivo;Infrastructure;Lead;Membrane;Messenger RNA;Modeling;Monitor;Mus;Neurobiology;Neurons;paralogous gene;Pathway interactions;Porosity;Proteomics;Pseudogenes;Reaction;Ribosomal Proteins;Ribosomes;Role;segregation;Sensory;stoichiometry;Stress;Testing;transcriptome sequencing;Translating;Translations;Up-Regulation;Wyoming

PROJECT_TITLE: The neurobiology of ribosomal proteins and ribosomal-protein-pseudogenes


ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE The Stanford U54 SARS-CoV-2 Serological Sciences Center of Excellence is a member of the SeroNet consortium organized to address the urgent need for better understanding of human immune responses to the SARS-CoV-2 coronavirus and vaccines targeting it. In the proposed Supplement funding for this award, we will carry out further investigations into SARS-CoV-2-specific responses in pregnancy; deep characterization of the evolution of B cell memory through the pandemic; structural studies of protective antibodies bound to their antigens; extensive analysis of class I epitope presentation of SARS-CoV-2 across human HLA alleles; and in- depth T cell and B cell analyses in patients with long Covid. The combined impact of these studies will be to extend understanding of the cellular and molecular mechanisms affecting immune responses to the continuing evolving SARS-CoV-2 viral populations in individuals with different prior exposure histories, and in some populations such as pregnant individuals or long Covid patients who have altered immunity.

PI_NAMEs: BOYD, SCOTT DEXTER (contact)

PROJECT_TERMS: 2019-nCoV;Achievement;acute COVID-19;adaptive immune response;Address;Affect;Alleles;Antibodies;Antigens;Award;B-cell receptor repertoire sequencing;B-Lymphocytes;Binding;Biological Assay;Cell Lineage;Cell Separation;Cells;Clinical;clinical implementation;Clinical Research;Collaborations;Communication;Coronavirus;COVID-19 pandemic;COVID-19 pathogenesis;COVID-19 patient;COVID-19 vaccine;Data;Databases;Development;Disease;Epitopes;Evolution;experimental study;Funding;Genomics;Goals;Guidelines;Human;Human Resources;Immune response;Immunity;Individual;Infection;Investigation;Long COVID;member;Memory B-Lymphocyte;Molecular;Molecular Analysis;Mucous Membrane;organizational structure;pandemic disease;Patient Recruitments;Patients;Performance;Plasma Cells;Population;Population Heterogeneity;Pregnancy;pregnant;Procedures;Reaction;Recording of previous events;Reporting;Research;response;RNA vaccine;Role;sample collection;SARS-CoV-2 immunity;Science;Serology;Sex Bias;Site;T cell response;T-Lymphocyte;Tissues;transcriptome;Translations;Vaccination;Vaccines;Variant;Viral;virology;Work;X Inactivation

PROJECT_TITLE: Mechanisms and Duration of Immunity to SARS-CoV-2 - Supplement Application for Sept 2024-Aug 2025


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PHANTOM AND AUTOMATED ANALYSIS FOR ADVANCED COMPUTED TOMOGRAPHY SYSTEMS Narrative This application is a supplement application to U01 EB034205-01, “Multiple x-ray source array (MXA) computed tomography”. In this proposal, the existing modular CT image quality phantom (called “Corgi”, produced commercially by the Phantom Laboratory) will be upgraded to include an additional module which includes the ability for automated analysis for both volume and texture accuracy, as well as software upgrades to include task-based model observer performance. The supplemental application will also address how these updates to the Corgi phantom will impact our assessment of the prototype CT scanner produced in the parent award and will also develop the users group to assess the utility of the new phantom module, the accompanying software analysis tools available online, and the NIST/NIBIB Phantom lending library infrastructure.

PI_NAMEs: BOONE, JOHN M (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: 3-Dimensional;Address;Administrative Supplement;Area;arm;automated analysis;Calibration;cancer imaging;Certification;Characteristics;Clinical;clinical implementation;Communities;Computer software;Cone;cone-beam computed tomography;Country;design;detector;Development;Diagnostic;Digital Imaging and Communications in Medicine;Documentation;Dose;dosimetry;Evaluation;Exhibits;Geometry;Image;Imaging Phantoms;imaging system;Imaging technology;improved;Infrastructure;Institution;Intervention;Investigation;Laboratories;Lesion;Libraries;Licensure;Manufacturer;Measurement;Medical;Methodology;Methods;metrology;Modeling;Morphologic artifacts;National Institute of Biomedical Imaging and Bioengineering;Noise;Ocular orbit;Output;parent project;Parents;Pattern;Performance;Photons;Procedures;Production;Protocols documentation;prototype;quality assurance;Quantitative Evaluations;quantitative imaging;Radiometry;radiomics;reconstruction;Reporting;Reproducibility;Research;Research Methodology;Research Personnel;Resolution;Roentgen Rays;Sampling;Scanning;Signal Transduction;Source;Specific qualifier value;Standardization;Structure;Surveys;synergism;System;Technology;Testing;Texture;Three-Dimensional Image;Three-Dimensional Imaging;tool;Update;Validation;web site;Work;X-Ray Computed Tomography

PROJECT_TITLE: Phantom and Automated Analysis for Advanced Computed Tomography Systems


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHANTILLY

ORG_NAME: FOUR POINTS TECHNOLOGY, LLC

ORG_STATE: VA

PI_NAMEs: LIPKIN, JOEL A (contact)

PROGRAM_OFFICER_NAME: WEBER, MICHAEL NICHOLAS N

PROJECT_TERMS: Acceleration;Address;Biomedical Research;Cloud Computing;Cloud Service;cloud storage;Communities;computerized tools;Data;Data Commons;data ecosystem;data repository;Data Science;Data Set;Economics;FAIR principles;Funding;Goals;Image;Individual;large datasets;Modeling;Modernization;Phase;Policies;Procedures;Process;programs;Research Infrastructure;Research Personnel;Science;Series;service providers;Services;Strategic Planning;Technology;Testing;United States National Institutes of Health;Work

PROJECT_TITLE: STRIDES


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Data Science;Networking and Information Technology R&D (NITRD);Substance Misuse

ORG_CITY: RESTON

ORG_NAME: CARAHSOFT TECHNOLOGY CORPORATION

PI_NAMEs: DRINKWINE, TERRY  (contact)


NIH_SPENDING_CATS: Data Science

ORG_CITY: ROUND ROCK

ORG_NAME: DELL FEDERAL SYSTEMS L.P.

PI_NAMEs: HAMMONDODWYER, AMY K (contact);SIDDIQUI, ERUM

PROJECT_TERMS: Acceleration;Address;Biomedical Research;Cloud Computing;Cloud Service;cloud storage;Communities;computerized tools;Data;Data Commons;data ecosystem;data repository;Data Science;Data Set;Economics;FAIR principles;Funding;Goals;Image;Individual;large datasets;Modeling;Modernization;Phase;Policies;Procedures;Process;programs;Research Infrastructure;Research Personnel;Science;Series;service providers;Services;Strategic Planning;Technology;Testing;Training;United States National Institutes of Health;Work

PROJECT_TITLE: NIH STRIDES - Azure and Associated Services and Training.


NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Intellectual and Developmental Disabilities (IDD)

PI_NAMEs: KELLY, ANDREA BRIDGET (contact);MILLER, VICTORIA ALLISON

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(80)-R]


ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative Serologic testing for presence of SARS-CoV-2 antibodies is a critical tool for understanding the epidemiology and designing control strategies for the COVID-19 pandemic. Within a large, integrated health system with rich demographic, behavioral and clinical data, we will develop and implement a large- scale, population-based, flexible platform to assess SARS-CoV-2 sero-prevalence, sero-incidence, risk of sero-conversion and longevity of antibody response. This study will be critical in enhancing our understanding of how to use commercially available, large-scale SARS-CoV-2 antibody testing for population-level and individual-level disease control.

PI_NAMEs: SKARBINSKI, JACEK  (contact)

PROGRAM_OFFICER_NAME: STARKS, VAURICE

PROJECT_TERMS: 2019-nCoV;7 year old;Address;aged;Antibodies;Antibody Response;Behavioral;Biological Assay;California;cancer therapy;care seeking;Characteristics;China;Clinical;Clinical Data;cohort;Collaborations;Collection;Communicable Diseases;Communities;comorbidity;Complement;COVID-19;COVID-19 diagnosis;COVID-19 incidence;COVID-19 pandemic;COVID-19 patient;COVID-19 risk;COVID-19 testing;Data;Data Sources;design;Development;Dimensions;Disease;Disease Surveillance;disorder control;effectiveness evaluation;Electronic Health Record;Enrollment;Epidemiology;Ethnic Origin;Evaluation;flexibility;follow-up;Health system;high risk population;Immunity;Immunologic Surveillance;Immunologic Tests;Incidence;Individual;Infection;Infrastructure;Inpatients;Integrated Health Care Systems;Link;Longevity;Malignant Neoplasms;Medical Records;member;Morbidity - disease rate;mortality;Outcome;Outpatients;pandemic disease;Patients;Persons;Polymerase Chain Reaction;Population;population based;Population Heterogeneity;Prevalence;prospective;Prospective Studies;Prospective, cohort study;Protocols documentation;Race;Recording of previous events;Recurrence;Risk;Risk Assessment;sample collection;Sample Size;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 exposure;SARS-CoV-2 infection;SARS-CoV-2 positive;Science;Scientist;Series;seroconversion;Serology;Serology test;seropositive;Seroprevalences;serosurveillance;Shelter facility;System;Testing;Time;tool;Variant;Viremia

PROJECT_TITLE: SARS-CoV-2 Serological Antibody Testing for Disease Surveillance and Clinical Use


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: Newark

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF DELAWARE

PHR: Project Narrative Small secreted extracellular vesicles play a critical role in communication between cells during physiological processes, cancer progression, and neurodegenerative diseases. The proposed research will provide new insights into how an individual cell packages and releases distinct populations of extracellular vesicles.

PI_NAMEs: TANIS, JESSICA E (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Afferent Neurons;Animal Behavior;Animal Communication;animal imaging;Animals;Biogenesis;Biological Markers;Biological Models;Body Fluids;Caenorhabditis elegans;Calcium;Candidate Disease Gene;Cell membrane;cell type;Cells;Cellular Stress;Chimeric Proteins;Cilia;Classification;Communication;Comprehension;Confocal Microscopy;Cultured Cells;Data;Defect;Detection;Development;Disease;Endocytosis;Engineering;Environment;Exclusion;exosome;extracellular vesicles;Flow Cytometry;Genetic;genetic approach;Goals;Hermaphroditism;Heterogeneity;Homeostasis;Image;Imaging Techniques;in vivo;Individual;insight;intercellular communication;interest;Investigation;Ion Channel;Kinesin;Label;Lateral;Lipid Bilayers;Lipids;macromolecule;male;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Membrane;Microscopy;microvesicles;Modeling;Molecular;Morphology;Multivesicular Body;mutant;Neurodegenerative Disorders;Neurons;novel;Pathologic;Phospholipids;Physiological;Physiological Processes;Play;Population;Population Heterogeneity;prevent;Proteins;Research;Resolution;RNA;Role;Site;Sorting;Stimulus;Structure;System;Techniques;Testing;Therapeutic;Time;Tissues;Transgenic Animals;Transmission Electron Microscopy;tumor progression;Vesicle;vesicular release;Visualization;Work

PROJECT_TITLE: Elucidating biogenesis and cargo sorting mechanisms for discrete extracellular vesicle subpopulations in C. elegans

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: This study tests the effectiveness of an innovative youth leadership and civic engagement program with a mindfulness component co-constructed with youth of color and designed to improve their wellbeing. In partnership with METCO in Boston, MA and Chicago Public Schools in Chicago, IL, we propose a randomized control trial to test the LEAP-M program. The novel LEAP-M study may be the only study that evaluates a youth activism and leadership program with a mindfulness-based intervention focusing on structural and neighborhood factors that youth of color aspire to change as a way to improve their wellbeing.

PI_NAMEs: CRUZ GONZALEZ, MARIO  ALBERTO;GREEN, JENNIFER GREIF (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: 2 arm randomized control trial;Address;Affect;after-school program;Agreement;arm;Awareness;behavioral health;behavioral health intervention;Black race;Boston;career preparation;Chicago;children of color;College Preparation;combat;Communities;comparison intervention;cost-effectiveness evaluation;COVID-19 pandemic;Data;Data Collection;demographics;Desegregation;design;Development;Discrimination;disparity reduction;Education;Educational Curriculum;effective intervention;Effectiveness;effectiveness testing;Emotional;Enrollment;Equity;ethnic disparity;experience;feasibility testing;Feedback;Fostering;Foundations;Goals;Health;human subject;Illinois;improved;Individual;Inequity;innovation;Institution;Intervention;intervention effect;Latinx;Lead;Leadership;Link;Massachusetts;Mental Health;Methodology;metropolitan;mindfulness;mindfulness intervention;Mindfulness Training;Minority;National Center for Complementary and Integrative Health;Neighborhoods;novel;Pathway interactions;peer;Personal Satisfaction;Phase;Pilot Projects;pilot test;Play;Politics;Procedures;programs;Protocols documentation;Psyche structure;racial disparity;Randomized;Randomized, Controlled Trials;recruit;Research;Role;school district;School Enrollments;Schools;Services;Side;Site;skills;social;Social Change;social factors;structural determinants;Structural Racism;Students;System;Testing;therapy design;Training;urban school;Work;Youth

PROJECT_TITLE: Can A Youth Civic Leadership, Engagement and Mindfulness Program Reduce Structural Racism, and Support Functioning and Well-being for Youth of Color?


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Nanotechnology;Prevention

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Our goal is to develop a more effective and targeted caries preventive approach for susceptible populations. It integrates a multifunctional strategy that disrupts virulent biofilms and prevents enamel demineralization under high cariogenic conditions. The agents are low cost and approved for clinical use facilitating product development

PI_NAMEs: KOO, HYUN  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acids;Affect;analog;anticaries;antimicrobial;Apatites;Area;Award;Binding;Biocompatible Materials;Biodistribution;Biological;Caries prevention;Catalysis;Chemicals;Clinical;clinical efficacy;Clinical Research;clinical translation;Clinical Trials;clinically relevant;Combined Modality Therapy;Communication;comparative efficacy;cost;Data;demineralization;dental biofilm;Dental caries;Dental Enamel;Development;Dextrans;Dose;effective therapy;Effectiveness;efficacy study;Enzymes;FDA approved;ferumoxytol;Fluorides;Formulation;Funding;Funding Mechanisms;Gingiva;Goals;gut microbiome;Hardness;Human;Hydrogen Peroxide;improved;In Situ;In Vitro;in vivo;Individual;Industry;Intellectual Property;internal control;iron deficiency;Iron deficiency anemia;iron oxide nanoparticle;Knowledge;Laboratories;Legal patent;Medical;metabolomics;Metagenomics;Methods;Microbial Biofilms;Microscopy;Modality;Modeling;Mouth Diseases;Mucous Membrane;multiple omics;nano;nanoparticle;Nature;new technology;novel;novel strategies;Oral;oral microbiome;Oral mucous membrane structure;oral tissue;Organ;Pathologic;Performance;Peroxidases;Physical Chemistry;polymicrobial biofilm;Population;Poverty;Precision therapeutics;Predisposition;prevent;Preventive;product development;Property;Publications;Radiolabeled;Regimen;response;Rodent;Rodent Model;safety and feasibility;Small Business Innovation Research Grant;soft tissue;Source;Specificity;Spectrum Analysis;Structure;Study models;sugar;Surface;synergism;Technology;Testing;tomography;Topical application;Toxic effect;transcriptomics;Treatment Efficacy;Treatment Protocols;Virulent;Work

PROJECT_TITLE: Biofilm Elimination and Caries Prevention using Multifunctional Nanocatalysts


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Inflammatory Bowel Disease;Primary Health Care;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE This supplement is to harmonize IBD genetics and social determinants of health data for two sites in the IBD Genetics Consortium. These data will be analyzed in order to optimize common data elements (CDE) for IBD for or deposition into the CDE Repository. By doing so, improved recruitment and phenotypic can occur, catalyzing Precision IBD.

PI_NAMEs: CHO, JUDY H. (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Acceleration;Adoption;Age;Age of Onset;Age Years;Algorithms;All of Us Research Program;Anal Fistula;Area;Autoimmunity;bilingualism;biomedical referral center;Black Populations;Black race;Canada;care outcomes;Caring;cell immortalization;Cell Line;Characteristics;Childhood;Chronic;Classification;Clinical;clinical care;Clinical Research;Clinical Trials;cohort;Collaborations;Common Data Element;Communities;comorbid depression;Consent;Consent Forms;cost;Crohn's disease;Current Procedural Terminology Codes;Data;Data Coordinating Center;data modeling;Data Set;database of Genotypes and Phenotypes;Databases;Dedications;Deposition;Development;Diagnosis;Diagnostic;Diarrhea;Disease;Disease Outcome;disorder subtype;Electronic Health Record;European ancestry;Evaluation;experience;Fast Healthcare Interoperability Resources;Flare;Functional disorder;Funding;Gastroenterologist;Genetic;genetic association;Genetic Determinism;Genetic Diseases;Genetic Research;Genetic Structures;Genetic study;genomic data;Goals;Gold;Guidelines;health care availability;Health Care Research;health data;health literacy;Health Services Accessibility;Health system;Healthcare;Human;Immune;improved;Incidence;Inflammation;Inflammatory;Inflammatory Bowel Diseases;informatics training;Injections;innovation;Insurance Coverage;International;international center;Internships;interoperability;Interruption;Intestines;Laboratories;Language;Latinx;Latinx population;Logical Observation Identifiers Names and Codes;lymphoblastoid cell line;Machine Learning;Maps;Measures;Mediating;medical schools;Mental Depression;Mining;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;New York;North America;novel;open source;Outcome;Participant;Patient Care;Patient Recruitments;Patient-Focused Outcomes;Patients;Phenotype;phenotypic data;PhenX Toolkit;Population;Population Heterogeneity;Prevalence;Primary Care;primary care patient;primary care provider;Procedures;Protocols documentation;Psychological Factors;Publishing;Qualifying;Questionnaires;Readability;Readiness;recruit;Reporting;repository;Research;Research Personnel;Resources;screening;Site;social;social health determinants;Social Justice;Societies;Spanish;Spanish/English;Specialist;Specialized Center;Stress;Structure;structured data;Symptoms;System;Testing;Training;Translational Research;Translations;Ulcerative Colitis;United States;United States National Institutes of Health;Universities;Validation;Visit

PROJECT_TITLE: Developing and applying common data elements to enhance clinical and translational research, healthcare access and outcomes in inflammatory bowel disease


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Human Genome;Infectious Diseases;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_DEPT: DERMATOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Hidradenitis suppurativa (HS) is an inflammatory skin disease with many unmet medical needs and a poorly resolved genetic architecture. Inborn errors of immunity (IEI) are single-gene disorders comprising a class of nearly 500 extensively studied genes that contribute to the genetic architecture of prevalent multifactorial disorders and can have important clinical implications for the patients that have an IEI by presenting opportunities for targeted interventions and individualized screening. Here we will identify HS research participants with an IEI, validate biological and clinical consequences of identified mutations, and establish gene-level and pathway- level evidence with exome burden testing and genome-wide association studies.

PI_NAMEs: PETUKHOVA, LYNN  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: African American population;Architecture;Atopic Dermatitis;Autoimmunity;biobank;Biological;Body System;Caring;cell type;Clinical;Clinical Data;clinical sequencing;Clinical Trials;clinically relevant;cohort;Cohort Studies;comorbidity;congenital immunodeficiency;Cytokine Signaling;Data;Diagnosis;Diagnostic;Disease;drug development;drug repurposing;Drug Targeting;Electronics;Etiology;Exclusion;exome;exome sequencing;FDA approved;Fibrosis;Functional disorder;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;Genetic study;genome wide association study;genome-wide;Genotype;healing;Hidradenitis Suppurativa;Human Genetics;Hyperplasia;Immune;immune system function;Immunologics;improved;in silico;Individual;industry partner;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Intervention;Level of Evidence;Mediating;Medical;Mendelian disorder;Meta-Analysis;Morbidity - disease rate;Mutation;older patient;Organ;Outcome;Pain;Participant;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phenotype;Population;Predisposition;Prevalence;Public Domains;Publishing;Research;response;Risk;Role;Running;Sampling;screening;Series;Signal Pathway;skin disorder;skin lesion;Source;STAT1 gene;success;Testing;therapeutic target;Time;Tissues;Validation

PROJECT_TITLE: Establishing the contributions of monogenic etiologies to hidradenitis suppurativa pathogenesis


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PUBLIC HEALTH RELEVANCE STATEMENT This study examines how oral Actinobacteria maintain proper folding of virulence factors during their assembly and under stress conditions. A clear understanding of these aspects will provide new targets for anti-infective therapies and prevention of oral biofilm-associated diseases.

PI_NAMEs: TON-THAT, HUNG  (contact)

PROJECT_TERMS: Actinobacteria class;Actinomyces;Address;Adhesives;Affect;Anabolism;Anti-Infective Agents;Attenuated;Bacterial Adhesins;Bacterial Infections;Binding;Biochemical;Bioinformatics;Biological Assay;Cell Physiology;Cell Wall;Cells;Cellular Morphology;Cellular Stress;Compensation;Corynebacterium;Corynebacterium diphtheriae;Coupled;Coupling;Crystallization;Crystallography;Cysteine;Defect;Dental Plaque;Disease;disulfide bond;Electron Transport;Enzymes;Eukaryota;Experimental Models;fitness;Funding;Genetic;genetic approach;Gram-Negative Bacteria;Gram-Positive Bacteria;Guanine + Cytosine Composition;interdisciplinary approach;Isomerase;Isomerism;Knowledge;Mediating;Membrane;Microbial Biofilms;misfolded protein;Modality;Modeling;Molecular;Monobactams;mutant;Mutation;Names;Nematoda;novel;Oral;oral biofilm;Oral Examination;Organism;overexpression;oxidation;Oxidoreductase;Pathway interactions;Penicillin-Binding Proteins;Peptidoglycan;Peptidyltransferase;periplasm;permissiveness;Phase;Pilum;polymicrobial biofilm;prevent;Prevention;Process;Prokaryotic Cells;Protein Export Pathway;protein folding;protein function;protein misfolding;Protein translocation;Proteins;Proteome;public health relevance;rational design;response;Roentgen Rays;Role;Stress;Stress and Coping;Structural Models;Structure;Sulfhydryl Compounds;System;Temperature;Thiol Disulfide Oxidoreductase;TXN gene;Virulence;Virulence Factors;vitamin K epoxide reductase

PROJECT_TITLE: Post-translocational protein folding in Gram-positive bacteria


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Type 2 diabetes mellitus (T2D) is the major form of human diabetes, accounting for approximately 90–95% of diagnosed diabetes cases in the United States. Our research is designed to provide insight into how the brain contributes to blood glucose regulation in T2D. Specifically, we aim to identify the neural factors responsible for the development of T2D and address a novel liver glucose metabolism-based mechanism of this disease.

PI_NAMEs: FENG EARLEY, YUMEI  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Accounting;Address;Agreement;Angiotensin II;Area;Autonomic nervous system;blood glucose regulation;Body Weight;Brain;Brain region;Cardiovascular system;Central Nervous System;Conscious;Consumption;Data;design;designer receptors exclusively activated by designer drugs;Development;Diabetes Mellitus;diabetic;Diagnosis;Disease;Eating;Electrophysiology (science);Energy Metabolism;feeding;Future;Genetic;Glucose;glucose disposal;glucose metabolism;glucose monitor;Goals;High Fat Diet;Homeostasis;Human;Hypothalamic structure;Impairment;improved;In Vitro;in vivo;Inactive Renin;insight;Insulin;insulin secretion;insulin sensitivity;interdisciplinary approach;Investigation;Knowledge;Ligands;Liver;Mediating;member;Metabolic;Metabolic Control;metabolic phenotype;Molecular;Monitor;Mus;Nervous System control;neural;Neural Pathways;neuromechanism;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;paraventricular nucleus;Pathogenesis;Peptides;Physiological;Plasma;Play;promoter;receptor;Regulation;Renin;Renin-Angiotensin System;Reporting;Research;response;Role;Signal Transduction;Slice;Synapses;System;Techniques;Telemetry;Testing;therapeutic target;Tissues;Tyrosine 3-Monooxygenase;United States

PROJECT_TITLE: Neural mechanisms regulating glucose homeostasis

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Learning powerfully influences nearly all brain functions, from early sensory processing and control of movement, to cognition. Deficits in learning and memory present a serious challenge to individuals and society. This project will generate insights about the neural processes that transfer memories from short- to long-term storage.

PI_NAMEs: GOLDMAN, MARK S;RAYMOND, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Amygdaloid structure;Area;Automobile Driving;Behavior;Behavioral;Brain;Brain region;candidate identification;Cell Nucleus;Cerebellum;Cognition;Computer Models;conditioned fear;Data;density;Dissection;Episodic memory;experience;experimental study;Eye Movements;Foundations;Goals;Hippocampus;improved;in vivo;Individual;insight;Learning;long term memory;Measures;medial vestibular nucleus;Mediating;Memory;memory acquisition;memory consolidation;Modeling;motor learning;Motor Skills;Movement;Nature;neural;neural circuit;neural patterning;Neurons;neurotransmission;oculomotor;optogenetics;Output;predictive modeling;Process;Research;Sensory;Shapes;Short-Term Memory;Site;Societies;Synapses;System;Testing;Time;Training;transmission process;vestibular system;Vision;visual information;Work

PROJECT_TITLE: Activity-Dependent Mechanisms of Memory Consolidation


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Johns Hopkins Excellence in Pathogenesis and Immunity Center for SARS-CoV-2 (JH-EPICS) Overall Narrative The goal of the Johns Hopkins Excellence in Pathogenesis and Immunity Center for SARS-CoV-2 (JH-EPICS) is to define the immune responses that can either protect or harm during infection. The JH-EPICS team will evaluate the immune responses required to detect the presence of SARS-CoV-2, initiate inflammatory responses, eliminate infected cells, and engage the antibody responses against the virus in COVID-19 patients. Using statistical analyses and modeling, JH-EPICS will identify the variables, such as demographic (e.g., age, sex, gender, race, and ethnicity) and clinical (e.g., severity of COVID-19 and comorbidities) factors, that predict COVID-19 immune responses and outcomes.

PI_NAMEs: COX, ANDREA L;KLEIN, SABRA L. (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: 2019-nCoV;Age;age difference;Antibodies;Antibody Response;antibody-dependent cell cytotoxicity;Antigens;Biometry;biosafety level 3 facility;Cell surface;Cells;Clinical;Collaborations;comorbidity;Complement;COVID-19;COVID-19 patient;COVID-19 severity;current pandemic;Development;Disease;Ensure;Enzyme-Linked Immunosorbent Assay;Epidemiology;Ethnic Origin;Evaluation;experimental study;Flow Cytometry;Gender;gender difference;Goals;Health;Human;Immune;Immune response;Immunity;Immunoglobulin Class Switching;Infection;Inflammasome;Inflammatory Response;innate immune sensing;insight;Interdisciplinary Study;intersectionality;Leadership;Mediating;Metabolic;Methods;Myeloid-derived suppressor cells;neutralizing antibody;new therapeutic target;novel;novel marker;Outcome;Pathogenesis;Pathologic;Pathology;Peripheral Blood Mononuclear Cell;Population;Proteins;Race;racial difference;Reagent;Regimen;Research;Research Project Grants;Resources;sample fixation;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 immune response;SARS-CoV-2 immunity;SARS-CoV-2 infection;Science;Serology;Serology test;Severity of illness;sex;Sex Differences;single cell analysis;Stains;Statistical Data Interpretation;Statistical Models;Surrogate Markers;T-Lymphocyte;Testing;therapeutic evaluation;Training;vaccine candidate;Vaccine Design;vaccine evaluation;Viral;virology;Virus


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Dengue vaccine development and evaluation is challenged by a lack of immunological correlates of protection and risk. A continued lack of understanding of durable protective immunity and, perhaps a more acute need, immune profiles that present increased risk threatens to present another failure of evaluation of current dengue vaccine candidates. Here, we propose to capture the diversity of non- neutralizing antibody and cellular responses from infection and vaccination alongside neutralizing responses to develop a better understanding of immunity and risk of dengue infection and illness.

PI_NAMEs: CUMMINGS, DEREK A (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute;Antibodies;Antibody Response;antibody-dependent cell cytotoxicity;Antibody-Dependent Enhancement;Antigenic Specificity;Antigenic Variation;Attenuated;Automobile Driving;B-Lymphocytes;Biological;Biological Assay;cohort;Collection;Complement Activation;Country;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Dengvaxia;design;Development;Dimensions;Disease;disorder risk;Effectiveness;epidemiology study;Evaluation;experience;Failure;follow-up;Grant;Human;Immune;Immune response;Immunity;Immunologic Markers;immunological diversity;Immunological Models;Immunologics;Immunology procedure;improved;Individual;Infection;infection risk;Label;Licensing;Licensure;Life Cycle Stages;Link;Longterm Follow-up;mathematical model;Measures;Mediating;Memory;Memory B-Lymphocyte;Modeling;Outcome;Participant;pathogen;Performance;Peripheral Blood Mononuclear Cell;phase 3 testing;Philippines;Population;Public Health;Recording of previous events;recruit;response;Risk;Risk Assessment;Risk Marker;Role;Safety;Sampling;serological marker;Severities;Severity of illness;System;T cell response;T-Lymphocyte;Thailand;Time;United States National Institutes of Health;unvaccinated;Vaccinated;Vaccination;vaccine candidate;vaccine development;vaccine evaluation;vaccine trial;Vaccinee;Vaccines;Work

PROJECT_TITLE: Identification of serological markers of protection and risk for dengue vaccines and natural infection

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: NARRATIVE Mitochondria, often described as power-houses of the cell, accumulate at sites within nerve cells where the power is needed. We are investigating the mechanisms that distribute mitochondria to where they are most needed to maintain the essential function of nerve cells. A better understanding of these mechanisms is essential, as a number of neurodegenerative diseases are associated with a failure of mitochondria to supply power as needed.

PI_NAMEs: MACLEOD, GREGORY TALISKER (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: 3-Dimensional;Adopted;Afferent Neurons;base;Behavior;Biology;Caenorhabditis elegans;Cell membrane;Cells;Code;Data;density;Docking;Drosophila genus;Electron Microscopy;Electrons;Endoplasmic Reticulum;Eukaryota;Face;Failure;Ganglia;Genes;Genetic;Glutamates;Goals;Golgi Apparatus;Individual;Ions;Iron;Knowledge;Laboratories;Larva;Life Cycle Stages;Light;Link;Lipids;Location;Lysosomes;Membrane;Metabolism;Mitochondria;mitochondrial dysfunction;Mitochondrial Membrane Protein;Modeling;Motor Neurons;Nerve;Neurodegenerative Disorders;Neurologic;Neurons;Neurophysiology - biologic function;neurotransmission;neurotransmitter release;Neurotransmitters;novel;Outer Mitochondrial Membrane;peroxisome membrane;Physiology;Positioning Attribute;Power Sources;presynaptic;presynaptic neurons;Presynaptic Terminals;Recycling;Reporting;Role;Scanning Electron Microscopy;Shapes;Site;Structure;Techniques;Testing;tool;ultra high resolution;Vertebrates;Yeasts

PROJECT_TITLE: Mitochondrial Interactions with the Plasmamembrane: Genetic Underpinnings and Functional Consequences at Drosophila Nerve Terminals

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_DEPT: OPHTHALMOLOGY

PHR: Project Narrative: We propose to develop and test a novel computer tool that can identify those who are diagnosed with orbital abscess and can benefit from early surgical drainage.

PI_NAMEs: FU, ROXANA  (contact);PU, JIANTAO

PROGRAM_OFFICER_NAME: ATRI, NEGIN S

PROJECT_TERMS: Abscess;Acute;Admission activity;Adult;Affect;Algorithms;Anatomy;Antibiotics;Artificial Intelligence;artificial intelligence algorithm;Automation;Biological Markers;Blindness;Brain;Cellulitis;Cessation of life;Characteristics;Child;Childhood;Clinical;clinical practice;Communities;Computational algorithm;Computer Models;Computers;Consumption;cost;Decision Making;Decongestants;demographics;design;Detection;Diagnosis;Drainage procedure;Emergency Situation;Ensure;Failure;Goals;healthcare burden;Healthcare Systems;high risk;Hour;Human;Image;improved;Infection;inpatient service;Inpatients;Institution;Intervention;Intravenous;Investigation;Journals;Length of Stay;Life;machine learning method;Manuals;Measures;Medical;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;novel;Operative Surgical Procedures;Ophthalmologist;Ophthalmology;Optic Nerve;Outcome;Patients;pediatric patients;Peer Review;Performance;predicting response;predictive modeling;prevent;Publishing;radiological imaging;Recommendation;Research;Research Personnel;response;Role;Sinus;Sinusitis;Site;spatial relationship;surgery outcome;Technology;Testing;therapy outcome;Time;tool;Treatment Efficacy;treatment guidelines;United States;Work;X-Ray Computed Tomography;X-Ray Tomography

PROJECT_TITLE: Automation of the radiographic surgical indicators for pediatric orbital abscess

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Aging;Brain Disorders;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative Constructing reliable individualized treatment strategies requires studies with fairly large sample sizes with longi- tudinal assessment of subjects over a relatively long period of time. To this end, we will create a harmonized and curated dataset by integrating data from seven long-term observational and randomized studies in Parkinson's disease. Using this harmonized data, we will develop and apply robust, rigorous and computationally efﬁcient methods for estimating an optimal individualized treatment strategy for Parkinson's disease with respect to var- ious outcomes (e.g., Uniﬁed Parkinson's Disease Rating Scale, quality of life, and Schwab and England ADL score). We will also leverage statistical machine learning approaches to improve the quality of the constructed optimal individualized treatment strategy while providing valid statistical inference.

PI_NAMEs: ERTEFAIE, ASHKAN  (contact);VENUTO, CHARLES STANLEY

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: Adoption;Alzheimer's Disease;analytical method;Caring;Characteristics;Clinical;Clinical Data;clinical phenotype;Clinical Research;clinical research site;Clinical Trials;comparative;Complex;Computer software;Coupled;Data;data harmonization;data integration;Data Set;Disease;dosage;England;flexibility;follow-up;Future;Goals;Guidelines;Heterogeneity;improved;Individual;individualized medicine;Language;Learning;machine learning method;Measures;Medical;Medicine;Methodology;Methods;Modeling;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Nature;Nervous System Disorder;Observational Study;Outcome;Parkinson Disease;Patients;Pattern;permissiveness;personalized approach;personalized medicine;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phenotype;Quality of life;Randomized;Recommendation;Relaxation;Research Personnel;Sample Size;Source;statistical and machine learning;Syndrome;Techniques;Therapeutic;Time;treatment strategy

PROJECT_TITLE: Advancing personalized medicine in PD using harmonized multi-site clinical data


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: Project Narrative (Relevance) The inability of tracking the locations of the alpha emitter 225Ac inside live subjects is hindering the adoption of targeted alpha therapy, an extremely promising cancer radiotherapy technique that uses the unique properties of alpha radiation to boost safety and efficacy. To overcome this major limitation, we propose a novel imaging system capable of imaging 225Ac pharmaceuticals during treatment of small animals by using a novel combination of two imaging techniques: Compton and proximity.

PI_NAMEs: CARAVACA, JAVIER  (contact)

PROJECT_TERMS: absorption;Acceleration;Acute Myelocytic Leukemia;Adoption;Algorithms;Alpha Particles;androgen independent prostate cancer;animal imaging;Animals;Attention;Beta Particle;Biodistribution;cancer radiation therapy;cancer therapy;carcinogenicity;CdZnTe;Cells;Clinical;clinical application;Collection;Daughter;Dedications;Deposition;design;Detection;detection sensitivity;detector;Development;Devices;Disease;DNA;Dose;Drug Kinetics;Event;Gamma Cameras;Gamma Rays;Goals;Head;Hour;Human;Hybrids;Image;imaging capabilities;Imaging Device;imaging system;Imaging Techniques;improved;in vivo;in vivo imaging;interest;Isotope Therapy;Isotopes;Lesion;Linear Energy Transfer;Location;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;Medical Imaging;millimeter;Modality;Motivation;multimodality;Mus;novel;Organ;Outcome;Patients;performance tests;Pharmaceutical Preparations;Pharmacologic Substance;pre-clinical;preclinical study;prevent;Property;prototype;quantitative imaging;Radiation therapy;Radioactive;Radioisotopes;Radiopharmaceuticals;reconstruction;Resolution;response;Safety;Signal Transduction;simulation;single photon emission computed tomography;Solid;Specific qualifier value;Specificity;success;System;Techniques;Technology;Thick;Time;Tissues;Toxic effect;Translating;Treatment Efficacy

PROJECT_TITLE: AC-225 Imaging R01 Transfer

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Headaches;Migraine;Neurosciences;Pain Research;Prevention

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Project Narrative This proposal will involve a pilot study to evaluate the feasibility, acceptability, and outcomes of regular lifestyle behavior (RLB i.e. regular sleep, exercise, mealtime) protocol in managing chronic migraine. Additionally, the proposal will investigate biomolecules that are uniquely involved in chronic migraine patients who respond to RLB. Successful completion of this proposal will inform the design of a future full- scale clinical trial testing the efficacy of RLB in chronic migraine, as well as provide the candidate with intensive, supervised training to help him become an independent research scientist focusing on headache medicine, more specifically on managing migraine using health-promoting lifestyle behaviors.

PI_NAMEs: WOLDEAMANUEL, YOHANNES WOUBISHET (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: acceptability and feasibility;adherence rate;Adverse effects;allostatic load;arm;Attention;Attenuated;Award;base;Behavior;Behavior Therapy;behavioral clinical trial;biobehavior;Bioinformatics;Biological;Biological Assay;candidate marker;career development;CD44 Antigens;Chronic;Clinical;Clinical Trials;Coenzyme A;cognitive control;comorbid depression;comparison control;compliance behavior;coping;cost;Cross-Sectional Studies;design;Development;Disease Management;efficacy testing;empowerment;Endowment;Exercise;feasibility testing;Frequencies;Future;Glutathione;Goals;Headache;Health Promotion;Informal Social Control;innovation;Intervention;Intervention Studies;K-Series Research Career Programs;Life Style;Lifestyle Therapy;Mass Spectrum Analysis;Measures;medication compliance;Medicine;Mentored Research Scientist Development Award;Mentors;metabolomics;Methods;Migraine;migraine treatment;multiple omics;National Institute of Neurological Disorders and Stroke;neuroinflammation;neurotransmission;non-drug;Nonpharmacologic Therapy;novel;Outcome;Oxidative Stress;Participant;patient engagement;Patients;Perception;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Pilot Projects;pilot test;Placebo Control;predictive marker;prevent;prospective;Proteomics;Protocols documentation;Provider;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Regimen;Research;Research Design;Research Personnel;Risk;Role;satisfaction;Scholarship;Scientist;Self Efficacy;Self Management;Serum;Severities;side effect;single molecule;skills;Sleep;Systems Biology;Technology;Testing;tool;Training;treatment as usual;Validation;Vascular Permeabilities

PROJECT_TITLE: Feasibility, Acceptability, and Pilot Testing of a Behavioral Intervention for Chronic Migraine


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Narrative Immunocompromised patients are at a higher risk for COVID-19 infection and poor outcome, are more likely to suffer from prolonged viral replication that fosters the development and propagation of new variants and have a poorer response to current vaccines. Of particular interest are patients treated with therapies that compromise the function of antibody-producing B cells and plasma cells (patients with autoimmune diseases and lymphoid malignancies such as lymphoma and myeloma) and lung cancer patients treated with immunotherapy. In this supplemental application, we will further investigate the precise immunological basis for these defects.

PI_NAMEs: DHODAPKAR, MADHAV V;SANZ, IGNACIO E. (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: 2019-nCoV;acute infection;Administrative Supplement;Antibodies;antibody test;Antigens;Autoimmune Diseases;Autoimmunity;autoreactivity;B-Lymphocytes;Bispecific Antibodies;booster vaccine;breakthrough infection;Cancer Patient;CD8-Positive T-Lymphocytes;cohort;COVID-19;COVID-19 vaccination;COVID-19 vaccine;Defect;defined contribution;design;Development;Epigenetic Process;Flow Cytometry;Fostering;Funding;Genetic Transcription;high risk;Immune response;Immunocompromised Host;Immunoglobulin-Secreting Cells;Immunologics;immunoregulation;Immunotherapy;interest;Legal patent;Long COVID;Lymphoma;Malignant lymphoid neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Multiple Myeloma;Non-Small-Cell Lung Carcinoma;Outcome;Pathogenesis;patient response;Patients;Plasma Cells;Post-Acute Sequelae of SARS-CoV-2 Infection;programmed cell death protein 1;programs;recruit;Regulation;Research;Resolution;response;SARS-CoV-2 immunity;SARS-CoV-2 infection;Secondary Immunization;single cell analysis;single cell ATAC-seq;Systemic Lupus Erythematosus;T cell response;Vaccination;vaccine immunogenicity;vaccine response;Vaccines;Validation;Variant;Viral;Virus Replication

PROJECT_TITLE: Administrative Supplement for Emory SeroNet "Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity"


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Digestive Diseases;Liver Disease;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative We will develop and distribute fabrication and calibration protocols so researchers can build anisotropic tissue- mimicking phantoms with selectable parameters that can be used to evaluate and improve the accuracy of quantitative aniostropic elasticity imaging systems. These systems provide noninvasive biomarkers for diseases in tissues such as skeletal muscle and brain, and these protocols will provide an industry-wide standard that will improve the diagnostic capabilities and provide quality assurance for these systems.

PI_NAMEs: NIGHTINGALE, KATHRYN RADABAUGH (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3-Dimensional;3D Print;Acceleration;Acoustics;Adoption;Biological Markers;biomarker development;biomechanical test;Biomechanics;Brain;brain tissue;Calibration;Clinical;Code;Collaborations;Communities;computerized data processing;Data;Dedications;design;Detection;Development;diagnostic value;Disease;Elasticity;elastography;fabrication;Funding;Goals;Health;Hydrogels;Image;imaging approach;imaging biomarker;Imaging Device;Imaging Phantoms;imaging properties;imaging system;Imaging Techniques;improved;Individual;Industry;Laboratories;Laboratory Research;Libraries;Liver;Liver Fibrosis;Magnetic Resonance Elastography;Magnetism;Measurement;mechanical properties;Mechanics;Methods;Modeling;Monitor;Multimodal Imaging;multimodality;Muscle Fibers;National Institute of Biomedical Imaging and Bioengineering;Nerve;Neuromuscular Diseases;Nuclear;Organ;parent grant;Procedures;Process;Property;Protocols documentation;quality assurance;quantitative imaging;Recipe;Reproducibility;Research;Research Personnel;Sampling;Site;skeletal disorder;Skeletal Muscle;Standardization;Structure;success;System;Techniques;Testing;Tissues;tool;treatment response;Ultrasonics;Ultrasonography;Universities;Validation;Virginia;Washington;Work

PROJECT_TITLE: 3D Shearwave Elasticity Biomarker Development for Neuromuscular Disease


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Microbiome;Natural Products;Neurosciences;Substance Misuse

ORG_CITY: FORT COLLINS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative Cannabis is the most commonly used drug among people who drink alcohol, and conflicting evidence suggests that cannabinoids (the chemical constituents of the cannabis plant, including delta-9-tetrahydrocannabinol [THC]) may confer both harms and benefits on the symptoms of alcohol use disorder (AUD). Animal studies suggest the effects of cannabis among heavy drinkers may be partially due to the impact of THC on the microbiota-gut-brain axis (MGBA; which refers to the bidirectional communication between the digestive, immune, and central nervous systems), however no human studies have explicitly explored this question. This observational study will inform our understanding of the risks and potential harm-reduction benefits of cannabis among heavy drinkers by investigating the effects of THC in legal-market cannabis on acute and daily alcohol consumption, AUD symptoms, and MGBA function among heavy drinking, regular cannabis users.

PI_NAMEs: KAROLY, HOLLIS C (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Acute;Alcohol consumption;alcohol effect;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Animals;Area;Biological Markers;Biometry;Blood;Cannabinoids;Cannabis;Cannabis policy;Cannabis retail;Central Nervous System;Chemicals;cognitive function;Communication;craving;Data;diaries;Dose;drinking;Drug usage;Goals;gut microbes;Harm Reduction;Heavy Drinking;Home;Human;Immune;Immune System Diseases;Impaired cognition;Impairment;Impulsivity;Institutional Review Boards;Legal;Link;Literature;marijuana use;marijuana user;Measures;Mentorship;Methods;microbiota;microbiota-gut-brain axis;neurobehavioral;novel;Observational Study;Outcome;patient oriented;Pattern;Persons;Pharmacology;Phenotype;Plants;pre-clinical;recruit;Research;Risk;Self Administration;skills;Symptoms;Testing;Tetrahydrocannabinol;Training;translational research program;Visit;Work

PROJECT_TITLE: Exploring the Effects of Cannabinoids on Alcohol Consumption and the Microbiota-Gut-Brain Axis