NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: WEINTRAUB, SANDRA  (contact)

PROJECT_TERMS: Address;aging brain;aging related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Area;Autopsy;Basic Science;Biodiversity;Brain;Clinic;Clinical;clinical conference;Clinical Research;Cognitive;Cognitive aging;Cognitive Science;cohort;Collaborations;Community Outreach;Consensus;Consent;Consultations;coronavirus pandemic;data access;data exchange;data integration;data management;data resource;Data Set;Databases;Dedications;Dementia;design;Diagnosis;Discipline;Disease;early onset;Education and Outreach;education research;Enrollment;Environment;Event;faculty research;Frontotemporal Lobar Degenerations;Funding;Goals;Grant;Heterogeneity;human subject;imaging biomarker;Impaired cognition;Individual;Infrastructure;innovation;Joints;Laboratories;Leadership;Longitudinal cohort;Measures;Medical Research;meetings;Mission;Modality;multidisciplinary;Nerve Degeneration;neurobehavior;neuroimaging;Neurology;neuropathology;Neuropsychology;Nonpharmacologic Therapy;novel;outreach;Participant;participant retention;Patient Recruitments;Patients;preservation;Prevention trial;Primary Progressive Aphasia;Productivity;programs;Progressive Aphasias;promote resilience;Psychiatry;Quality Control;Quality of life;recruit;Research;Research Personnel;Research Priority;Research Project Grants;resilience in aging;Resistance;Resources;Role;Social Work;Social Workers;Source;statistics;Structure;symposium;synergism;Therapeutic;Time;Tissue Donations;Training;Translating;volunteer;Work;Writing

PROJECT_TITLE: Clinical Core


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE In this cluster-randomized control trial, we will demonstrate the effectiveness of one-stop service pathway to reduce the burden of PrEP visits and cost of PrEP delivery in Kenyan public health settings. We hypothesize that simplified one-stop PrEP service model will significantly shorten client visit time, minimize stigma, and free providers for other work without adversely affecting the quality of PrEP services compared to standard client pathway. This innovative system-focused model will be cost-saving, sustainable, and a model of patient-centered PrEP care for PrEP programs in Kenya and elsewhere in Africa.

PI_NAMEs: BUKUSI, ELIZABETH ANNE;MUGWANYA, KENNETH KIGGUNDU (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: Adherence;Adoption;Affect;Africa;African;AIDS prevention;arm;Behavior;Behavioral;Benchmarking;Blood;budget impact;Budgets;Caring;Client;Clinic;Clinic Visits;Clinical;Cluster randomized trial;cohort;Collaborations;Consultations;Contacting Client;cost;Cost Analysis;cost estimate;Cost Savings;Counseling;Data;design;Detection;Diphosphates;Dryness;Effectiveness;effectiveness evaluation;effectiveness testing;Enrollment;Epidemic;Evaluation;experience;feasibility testing;Funding;Future;Guidelines;Health;health assessment;Health care facility;Health system;HIV;HIV risk;HIV/STD;Human immunodeficiency virus test;implementation evaluation;implementation framework;implementation outcomes;implementation process;implementation strategy;implementation/effectiveness;improved;innovation;Intervention;Kenya;Learning;Longitudinal Studies;Methods;microcosting;Modeling;Motivation;opportunity cost;Oral;Outcome;Parents;Pathway interactions;patient oriented;Patients;Persons;Pharmaceutical Preparations;Pharmacy facility;Pilot Projects;Policy Maker;pragmatic randomized trial;pre-exposure prophylaxis;preference;Prevention;primary outcome;Proctor framework;programs;Provider;Public Facilities;Public Health;Public Sector;Random Allocation;Randomized;randomized trial;Randomized, Controlled Trials;Readiness;recruit;Resources;Risk;satisfaction;scale up;Service delivery model;Services;skills;social stigma;Spottings;Suggestion;Supervision;System;Systems Analysis;Tenofovir;Testing;Time;Time and Motion Studies;Training;Translating;treatment as usual;treatment program;Triage;United States National Institutes of Health;uptake;Visit;Wait Time;Woman;Work;Workload

PROJECT_TITLE: Simplifying PrEP delivery: One-stop service pathway to improve PrEP care efficiency and continuation in Kenya

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Infectious diseases pose emerging, ongoing, and evolving threats to society, and physician-scientists dealing with infectious diseases are crucial to meet these challenges. This T32 program will support the research career training of fellows enrolled in the adult and pediatric Infectious Diseases Fellowship Programs at the David Geffen School of Medicine at UCLA, who wish to pursue careers as physician-scientists. These trainees will have access to a breadth of infectious diseases-related research ranging from molecular virology to social science across any department at UCLA and its affiliated academic institutions.

PI_NAMEs: HOFFMAN, RISA M.;NIELSEN, KARIN ;YANG, OTTO O (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: Address

PROJECT_TITLE: Addressing Evolving Infectious Threats

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: MILWAUKEE

ORG_DEPT: PEDIATRICS

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Type 1 diabetes (T1D) is caused by autoimmune attack of pancreatic beta cells. Our proposed work will comprehensively define the CD137-CD137L immune pathway operative in T1D and define the mechanisms of a novel immunosuppressant molecule, laying the groundwork for a novel therapeutic approach to human T1D.

PI_NAMEs: CHEN, YI-GUANG  (contact);RIDGWAY, WILLIAM M

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Acute;adaptive immunity;Address;Affect;Age;Alleles;Antigen-Presenting Cells;Attention;Autoimmune;autoimmune pathogenesis;autoreactivity;Beta Cell;Binding;Biology;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Complex;conditional knockout;Congenic Mice;cytokine;Data;diabetes mellitus therapy;diabetes pathogenesis;diabetogenic;Down-Regulation;effector T cell;efficacy testing;FOXP3 gene;FRAP1 gene;Gatekeeping;Genes;Grant;Half-Life;Homeostasis;Human;humanized mouse;Immune;immune activation;Immune response;Immune signaling;Immunity;Immunosuppressive Agents;improved;In Vitro;in vivo;in vivo Model;Inbred NOD Mice;Inflammation;Inflammatory;Insulin-Dependent Diabetes Mellitus;Intervention;Investigation;islet;Kinetics;Knockout Mice;Mediating;Modeling;monocyte;mouse model;Mus;Myelogenous;Natural Immunity;non-diabetic;novel;novel therapeutic intervention;Pathogenicity;Pathway interactions;Patients;Peripheral;Phenotype;Production;Progress Reports;Proliferating;Proteins;Publishing;Regulation;Regulatory T-Lymphocyte;Role;Serum;Signal Induction;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Source;Structure of beta Cell of islet;Surface;System;T cell anergy;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Translating;Work

PROJECT_TITLE: Mechanistic and therapeutic role of the CD137-CD137L axis in Type 1 Diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(02)]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PI_NAMEs: WEHBE, FIRAS HAZEM (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Applications Grants;Applied Research;Area;Automation;biomedical informatics;Biometry;cell type;Cells;Clinical;Clinical Sciences;Collaborations;Consultations;Data;Data Analyses;Data Collection;data management;Data Set;Databases;Democracy;design;Development;digital;Education;Educational Activities;Equipment and supply inventories;Extramural Activities;flexibility;follow-up;Generations;Goals;graduate student;Grant;Grant Review;Image;imaging biomarker;Immunofluorescence Immunologic;Informatics;Infrastructure;innovation;Institution;interest;Investigation;Journals;Leadership;Linear Models;Methods;Microglia;Modeling;Monitor;neuropathology;novel;operation;outreach;Paper;Pathologic;Patients;Play;Postdoctoral Fellow;pre-doctoral;Process;protein TDP-43;Proteins;Published Comment;recruit;Research;Research Activity;research and development;Research Design;Research Personnel;Research Project Grants;Resources;response;Review Committee;Role;Secure;Signal Transduction;Statistical Data Interpretation;Statistical Methods;statistics;Structure;Time;tool;Training;Translational Research;transmission process;Universities;Writing

PROJECT_TITLE: Data Management and Statistical Core


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_CITY: LINCOLN

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE This project will examine linkages between proximal risk factors, affect regulation, and coping behavior, using survey and ecological momentary assessment (EMA) data from youth experiencing homelessness (YEH). From these data, this project will develop a data-driven app-based just-in-time personal support intervention (JIT-PSI) that delivers responsive messaging to mitigate negative coping in favor of positive coping among YEH. Leveraging growing number of public free WiFi hotspots and shrinking cellphone hardware costs, this project will yield significant public health impacts by developing a sustainable, high-impact JIT behavioral intervention for the prevention of drug use among YEH.

PI_NAMEs: TYLER, KIMBERLY A (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: acceptability and feasibility;adolescent substance use;Affect;Age Years;Alcohol consumption;Alcohols;Behavior Therapy;Cellular Phone;Collaborations;Computer Models;computerized tools;coping;Coping Behavior;cost;Data;design;deter alcohol use;Development;diagnostic criteria;drinking behavior;drug abuse prevention;Drug usage;Ecological momentary assessment;efficacy trial;Emotions;experience;Face;feasibility testing;Focus Groups;Future;General Population;Goals;Growth;Health Care Costs;HIV;Homelessness;Impulsivity;Intervention;intervention delivery;Lifestyle-related condition;Machine Learning;Marijuana;marijuana use;Mediating;meetings;member;Mental Depression;Mental Health;methamphetamine use;National Institute of Drug Abuse;negative affect;observational cohort study;Outcome;Ownership;peer;Personal Satisfaction;Persons;Pilot Projects;Population;Post-Traumatic Stress Disorders;predictive modeling;Prevalence;protective factors;Public Health;public health research;Regulation;Reporting;Research;Risk;Risk Factors;Role;smartphone application;Social Network;Stress;substance use;Substance Use Disorder;Surveys;Text Messaging;therapy design;Time;Victimization;Vulnerable Populations;wireless fidelity;Work;young adult;Youth

PROJECT_TITLE: Street Experiences, Affect, and Coping: Harnessing Computational Models for the Development of a Cellphone-Based Intervention to Prevent Drug Use among Youth Experiencing Homelessness

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: FLANAGAN, MARGARET E (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Autopsy;behavioral variant frontotemporal dementia;Bilateral;Biological Markers;Brain;cellular pathology;cholinergic;Clinical;clinical phenotype;Cognitive aging;Collaborations;Complex;Data;Databases;Dementia;Densitometry;Detection;Diagnosis;Diagnostic;Discipline;Disease;disease diagnosis;Doctor of Philosophy;Early Diagnosis;education research;Effectiveness;Evolution;experience;Faculty;Family;Fertilization;Floor;Formulation;Fostering;Frontotemporal Lobar Degenerations;Goals;graduate student;Heterogeneity;Image;imager;imaging biomarker;in vivo;Incubators;Individual;Infrastructure;interest;Knowledge;Laboratories;Lead;Link;Literature;Location;meetings;member;Mentorship;Methods;middle age;Molecular;morphometry;Movement Disorders;multidisciplinary;Nature;Neuroanatomy;neuroimaging;neuroinflammation;neuropathology;Neuropsychology;next generation;Paper;Participant;Pathology;Pharmaceutical Preparations;Positioning Attribute;Postdoctoral Fellow;Primary Progressive Aphasia;Productivity;Progressive Aphasias;Protocols documentation;Qualifying;Research;Research Personnel;Research Project Grants;Resources;Retirement;super ager;Syndrome;System;Tissue Sample;Training;Universities;Work

PROJECT_TITLE: Neuropathology Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Microbiome

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE Shifts in the composition and function of human-resident microbial communities (microbiomes) are increasingly implicated as determinants of human health. The proposed research program will use in vitro and in vivo model systems to gain mechanistic insight into the ways in bacteriophages (phages) affect the composition and function of gastrointestinal microbiome. This work will provide a foundation for future basic and translational efforts to understand and exploit phage-bacteria-host interactions to mitigate disease.

PI_NAMEs: HRYCKOWIAN, ANDREW JOHN (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Affect;Antibiotic Resistance;Antibiotics;Bacteria;bacterial genetics;Bacteriophages;Bacteroides thetaiotaomicron;Biological Models;Biology;Cells;Collection;Communities;Data;Development;Disease;Family;Feces;Foundations;Future;gastrointestinal function;Gastrointestinal tract structure;Generations;Gnotobiotic;Goals;gut microbiome;Health;Heterogeneity;host microbiome;Human;Human Microbiome;human model;human pathogen;In Vitro;in vivo Model;Infection;insight;Knowledge;member;Methods;microbial community;microbiome;microbiome components;microbiome research;Mus;neglect;Phenotype;Play;Productivity;programs;Recovery;Reproducibility;Research;Resistance;Role;Scientist;Systems Biology;Therapeutic;tool;Work

PROJECT_TITLE: From cells to communities: The multi-scale impacts of bacteriophages in the gut microbiome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Diabetes;Genetics;Human Genome;Neurosciences;Nutrition;Obesity;Sleep Research

PHR: PROJECT NARRATIVE The world-wide epidemics of obesity and metabolic syndrome represent a major public health threat that is due in part to increased around-the-clock access to highly-palatable carbohydrate-rich food that leads to impaired glucose tolerance. Our proposed studies build upon our prior work showing an essential role for both brain and peripheral clocks in regulating hunger and whole-body glucose metabolism. Our new project will elucidate (i) the role of the clock in -cell insulin secretion in morning and night and (ii) how brain clocks balance the rival needs to eat and sleep, findings which will elucidate the basis for impaired glucose tolerance in obesity.

PI_NAMEs: BASS, JOSEPH  (contact);LERNER, TALIA NEWCOMBE

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: Ablation;Automobile Driving;B-Lymphocytes;Behavior;Behavioral;Beta Cell;blood glucose regulation;Brain;Carbohydrates;Cell Physiology;Cells;Chromatin;circadian;circadian pacemaker;circadian regulation;Circadian Rhythms;Consumption;Cyclic AMP Response Element;Desire for food;Diabetes Mellitus;Dimensions;Diurnal Rhythm;dopaminergic neuron;Eating;energy balance;Equilibrium;Exposure to;Feedback;feeding;Feeding behaviors;Food;gene network;Genetic;Genetic Transcription;Genomics;Glucose;glucose metabolism;glucose tolerance;Goals;Grant;Health;hedonic;High Fat Diet;Homeostasis;Hormones;Human;Hunger;Hyperphagia;Hypothalamic structure;impaired glucose tolerance;Impairment;innovation;insight;Insulin;insulin secretion;islet;Light;Link;Metabolic syndrome;Metabolism;Midbrain structure;Modernization;Molecular;molecular clock;Molecular Conformation;Motivation;Mus;Neurons;Obesity;Obesity Epidemic;obesity prevention;Periodicity;Peripheral;Physiological;Physiology;Prosencephalon;Public Health;Regulation;Rewards;RNA Processing;Role;shift work;Site;Sleep;Sleep disturbances;Sleep Wake Cycle;Societies;Testing;three dimensional structure;Time;transcription factor;transcriptomics;Variant;Ventral Tegmental Area;Work

PROJECT_TITLE: Integration of Feeding Time and Glucose Metabolism by the Circadian Gene Network

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Heat exposure is a contributor to dehydration and therefore can affect kidney function. We propose to investigate the relationship between heat (outdoor high temperatures and heat waves) and presentations of acute kidney injury (AKI) at emergency departments in Atlanta, GA. With a focus on improved AKI case ascertainment, heat exposure assessment, and identification of heat-vulnerable populations, this work will fill major gaps in the epidemiology of heat and AKI that will ultimately support public health prevention and clinical case management.

PI_NAMEs: EBELT, STEFANIE  (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Accident and Emergency department;Acute Renal Failure with Renal Papillary Necrosis;Address;Admission activity;Affect;Age;Air Pollution;Area;care seeking;Case Management;Chronic Kidney Failure;Classification;climate change;Clinical;clinical care;clinical data warehouse;clinical database;Code;Communities;comorbidity;Computerized Medical Record;Creatine;Data;Databases;Dehydration;demographics;Diabetes Mellitus;Diagnosis;Diarrhea;disease diagnosis;Economic Burden;Economic Conditions;economic evaluation;Education and Outreach;Educational Activities;Electrolytes;Emergency department visit;Epidemiology;Ethnic Origin;Exposure to;Future;Goals;Health;health data;health disparity populations;Heat Waves;High temperature of physical object;Hospitalization;Hospitals;Hypertension;improved;improved outcome;Incidence;Individual;International Classification of Diseases;Intervention;Kidney;Kidney Diseases;Link;Literature;Location;Measures;Medical;Modeling;Monitor;Outcome;Outcome Assessment;patient health information;Patients;Pharmaceutical Preparations;Population;Population Study;Prevention;Public Health;Race;Recording of previous events;Recurrence;Renal function;Reporting;Resolution;Risk;Risk Assessment;Risk Factors;Serum;Severities;sex;Site;sociodemographics;socioeconomics;Temperature;Time;United States National Institutes of Health;Universities;Urination;Visit;Vomiting;Vulnerable Populations;Water;Work

PROJECT_TITLE: Heat and Acute Kidney Injury: A Detailed Assessment using Electronic Medical Records and High-Resolution Exposure Modeling

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Behavioral and Social Science;Brain Disorders;Caregiving Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: MORHARDT, DARBY  (contact)

PROJECT_TERMS: Adult;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Awareness;behavioral variant frontotemporal dementia;Brain;caregiver education;Cities;Clinic;Clinical;Clinical Trials;Cognitive;Collaborations;community advisory board;community center;community engaged approach;community engagement;community partnership;Counseling;Dementia;design;Development;Disease;disease heterogeneity;Education;Ensure;equity, diversity, and inclusion;Evaluation;Family;family caregiving;follow-up;Funding;Goals;Heterogeneity;Impaired cognition;innovation;Intervention;intervention program;Leadership;Life;Memory;middle age;mild cognitive impairment;Mission;neurobehavior;Neurology;Nonpharmacologic Therapy;novel;outreach;Participant;participant retention;Pathway interactions;patient oriented;Patient Recruitments;Patients;Persons;Primary Progressive Aphasia;programs;psychosocial;Psychosocial Assessment and Care;public education;recruit;Research;Research Priority;research study;resilience;Resources;Role;Symptoms;Technology;Telephone;Therapeutic;Trust;Underrepresented Populations;Work

PROJECT_TITLE: Outreach, Recruitment, and Engagement Core


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Primary Health Care;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Patients with disabilities affecting communication (e.g., hearing, speech, language disabilities) experience significant disparities in the receipt of high-quality, equitable healthcare services. To understand and address disparities in care, healthcare organizations need to systematically document patients’ disability status in the electronic health record and then use that data meaningfully. This project will test implementation strategies to support primary care practices in (a) systematically documenting patients’ communication disabilities and needs in the electronic health record, and (b) providing needed disability accommodations, with the overarching goal of promoting equitable healthcare for individuals with communication disabilities.

PI_NAMEs: MORRIS, MEGAN A (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Academy;Address;Adoption;Adult;Adverse event;Advocate;Affect;Americans with Disabilities Act;Appointment;Arthritis;Asthma;care outcomes;Caring;Characteristics;Chicago;Chronic;Clinic;Clinical;Collection;Colorado;Communication;Communication Board;Communication Disability;Communities;Data;demographics;design;Diabetes Mellitus;Disabilities experience;disability;Disability accommodations;Disability status;Disabled Persons;Disparity;Documentation;Educational Intervention;effectiveness/implementation trial;Elderly;Electronic Health Record;Ensure;Equitable healthcare;Equity;Ethnic Origin;Event;evidence base;experience;federal policy;Gender Identity;Goals;Health;health care availability;health care disparity;health care service;health care service organization;health care settings;health data;health disparity;health equity promotion;health information technology;Health system;Healthcare;Healthcare Systems;Hearing;Hearing Aids;Hospitalization;Hybrids;Hypertension;implementation evaluation;implementation outcomes;implementation strategy;Individual;Infant Mortality;Inpatients;Intake;Intervention;Justice;Language;Language disability;Learning;Literature;Maps;marginalized population;Maternal Mortality;Medical;Medical History;Medicine;Methods;Outcome;Patient Care;patient oriented;patient portal;Patients;Persons;Policy Maker;Population;Practical Robust Implementation and Sustainability Model;primary care clinic;primary care practice;primary care setting;primary outcome;Process;programs;Provider;Quality of Care;Race;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Rural;safety net;Sex Orientation;social;social health determinants;Social support;Source;Speech;Testing;United States;Visit;Voice;willingness;Woman;Women's Health;Work

PROJECT_TITLE: Implementation of Communication Disability Collection and Accommodations in Primary Care Settings

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prescription Drug Misuse;Substance Misuse;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The focus of our research proposal is to dissect the neuronal and cellular mechanisms underlying alterations in opioid circuits that lead to opioid misuse in pain conditions and in a sex-dependent manner. Findings generated from the proposed research will provide critical insight on the circuit-based mechanisms underlying pain-induced increase in opioid intake with an insight on sex differences, transforming our understanding of opioid misuse and abuse.

PI_NAMEs: MORON-CONCEPCION, JOSE A (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: abuse liability;Address;Adult;adverse outcome;Analgesics;Behavior;Calcium;Cell Nucleus;cell type;Cells;Chronic;chronic pain;Clinical Data;Compensation;Consumption;Data;Development;Dopamine;dopaminergic neuron;Dose;Electrophysiology (science);Exhibits;experience;Female;Fentanyl;fentanyl seeking;fentanyl self-administration;Fiber;functional adaptation;High Prevalence;in vivo;inflammatory pain;insight;Intake;Laboratory Finding;Lead;Light;male;Measures;Mediating;Membrane Potentials;men;mesolimbic system;misuse of prescription only drugs;motivated behavior;Neurobiology;neuronal excitability;Neurons;Nucleus Accumbens;Opioid;opioid abuse;Opioid Analgesics;opioid misuse;opioid mortality;opioid use;opioid use disorder;opioid user;Opsin;Overdose;Pain;Pain management;pain patient;pain reduction;pain sensitivity;pain symptom;Pathway interactions;Pattern;Persistent pain;Photometry;Physiology;Play;Population;pre-clinical;Pre-Clinical Model;Predisposition;prescription opioid;prescription opioid misuse;Prevalence;Process;Property;Rattus;Recording of previous events;Reporting;Research;Research Proposals;Rest;reward processing;Rewards;Risk;Role;Self Administration;sex;Sex Differences;Slice;synaptic function;Testing;Time;transmission process;trend;uptake;Ventral Tegmental Area;Woman;women versus men

PROJECT_TITLE: Sex-specific mechanisms underlying the effects of pain on opioid seeking

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE  Autistic children have difficulty understanding texts with more social texts like narrative fiction stories compared to less social texts like expository nonfiction. The goal of this project is to examine how child factors related to children’s language and social communication abilities as well as text factors related to the complexity of linguistic and social information in a text predict autistic children’s comprehension of more and less social stories. This project sets the stage to develop clinical tools and a dynamic intervention approach that adjusts texts to meet child profiles of comprehension and instructional needs for individualized intervention.

PI_NAMEs: DAVIDSON, MEGHAN MATTHEWS (contact)

PROGRAM_OFFICER_NAME: COOPER, JUDITH

PROJECT_TERMS: 12 year old;autistic;autistic children;Child;Child Language;Child Welfare;Clinical;Comprehension;comprehension deficit;fictional works;Goals;Health;Heterogeneity;Individual;Individual Differences;individuals with autism spectrum disorder;Instruction;Intervention;Knowledge;Linguistics;listening comprehension;Measures;mental representation;Methodology;Modeling;novel;novel strategies;Outcome;Pilot Projects;Population;precision medicine;Predictive text;Principal Investigator;psychosocial;psychosocial wellbeing;reading comprehension;Reporting;Sampling;School-Age Population;social;social communication;social communication impairment;social factors;success;syntax;Text;theories;theory of mind;tool;Vocabulary;Vocation;Work

PROJECT_TITLE: More and Less Social Comprehension: Child and Text Factors for Autistic Children

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: PARRISH, TODD B (contact)

PROJECT_TERMS: Achievement;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;amnestic mild cognitive impairment;Area;Autopsy;Biological Markers;Biomedical Engineering;Clinical;cluster computing;Cognitive;cohort;Collaborations;Data;data archive;data integration;data management;Data Set;Databases;Dedications;Dementia;Diagnostic;Differential Diagnosis;Discipline of Nuclear Medicine;Eligibility Determination;Ensure;Extramural Activities;falls;Functional Imaging;Funding;Future;Goals;Heterogeneity;High Performance Computing;Hospitals;Image;image translation;imaging biomarker;imaging modality;Impaired cognition;improved;Individual;Infrastructure;Institution;Magnetic Resonance Imaging;Methods;Mission;molecular imaging;multimodal neuroimaging;National Institute of Neurological Disorders and Stroke;National Institute on Deafness and Other Communication Disorders;Natural History;neuroimaging;Output;Participant;PET/CT scan;Phase;Phenotype;Positron-Emission Tomography;Process;quality assurance;Radiology Specialty;Records;recruit;Research;Research Personnel;Research Project Grants;Resources;Running;Scanning;statistics;structural imaging;Structure;tool;training opportunity;Translational Research;Universities

PROJECT_TITLE: Imaging Biomarker Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE – OVERALL Targeted radionuclide therapies are a type of cancer treatment that can be injected into a patient’s vein and, after circulating through the patient’s body, these will preferentially accumulate in tumors and selectively deliver radiation to these locations. Radiation can damage tumors in a way makes them more susceptible to being killed by a patient’s own immune cells. Here, we will evaluate what effects targeted radionuclide therapies have on immune recognition of tumor cells and we will test whether these agents may enhance response to diverse forms of cancer immunotherapy – all in an effort to develop non-toxic, curative treatment approaches for patients with metastatic cancers of any type.

PI_NAMEs: MORRIS, ZACHARY SCOTT;WEICHERT, JAMEY P (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: adaptive immunity;Advisory Committees;Age;anti-tumor immune response;antigen-specific T cells;Antigens;Antitumor Response;Award;Bioinformatics;Biometry;burden of illness;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;Canis familiaris;Categories;Cells;clinical translation;clinically relevant;Clonal Expansion;Companions;Complex;Core Facility;curative treatments;cytokine;Data;Development;Disease;Disseminated Malignant Neoplasm;Distant;Dose;Dose Rate;dosimetry;Ensure;exhaustion;experience;External Beam Radiation Therapy;FDA approved;Funding Mechanisms;Image;Immune;Immune checkpoint inhibitor;Immune system;Immune Tolerance;immunogenicity;Immunologics;immunoregulation;Immunosuppression;Immunotherapy;improved;in situ vaccine;in vivo;Industry Collaboration;Institution;Interferon Type I;Investigational Therapies;Knowledge;Leadership;Ligands;Location;Low Dose Radiation;Malignant Neoplasms;Mediating;Methods;Microscopic;Modality;Modeling;Molecular Target;multidisciplinary;Mus;Mutation;neoantigens;neoplastic cell;next generation;novel;Oncology;Patients;Pharmaceutical Preparations;Predisposition;Process;Program Research Project Grants;programs;Protocols documentation;Radiation;Radiation therapy;Radiochemistry;Radioisotopes;Radiolabeled;Radionuclide therapy;Radiopharmaceuticals;receptor;Regimen;Research;research clinical testing;research facility;Resources;response;Role;Safety;Services;Site;success;T cell infiltration;T cell response;T-Cell Activation;Testing;Therapeutic;Toxic effect;tumor;Tumor Immunity;tumor microenvironment;Tumor-infiltrating immune cells;Vaccines;vector;Veins;Whole-Body Irradiation

PROJECT_TITLE: Molecular Targeted Radionuclide Therapy for Tumor Immunomodulation and Enhancing Immunotherapy Response


PHR: PROJECT NARRATIVE – PROJECT 1 Our immune system protects us from the majority of invasive diseases but cancer cells are often able to avoid detection by our immune system. It has recently been discovered that combining radiotherapy with immunotherapy is more effective than either treatment alone. Conventional radiation therapy typically cannot treat all tumor sites in patients with metastatic disease because of potential side effects and because of its inability to target small tumors that are not seen on imaging scans. We have overcome these limitations by combining radioactive tumor-seeking molecules with different types of immunotherapy, and our goal is to determine how this type of treatment renders tumors more responsive to immunotherapy and to ultimately use imaging to optimize this treatment approach for cancer patients.

PI_NAMEs: WEICHERT, JAMEY P (contact)

PROJECT_TERMS: 90Y;absorption;Affect;analog;Anatomy;Antitumor Response;Binding;Biodistribution;Biological;Blood;Bone Marrow;cancer cell;Cancer Patient;Canis familiaris;Cell Count;Cellularity;checkpoint inhibition;Chelating Agents;chelation;Clinical;Combined Modality Therapy;Companions;Detection;Diagnostic Imaging;Disease;DNA Vaccines;Dose;Dose Rate;dosimetry;draining lymph node;Exhibits;External Beam Radiation Therapy;FDA approved;FOLH1 gene;Goals;Image;Immune;Immune system;Immunologic Memory;immunoregulation;Immunosuppression;Immunotherapy;In complete remission;in situ vaccination;in vivo;Interferon Type I;Isotopes;Knowledge;Linear Energy Transfer;Location;Low Dose Radiation;Lymphopenia;Malignant Neoplasms;Measurement;metaiodobenzylguanidine;Microscopic;Modality;Modeling;Molecular Target;Monoclonal Antibodies;mouse model;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel;Organ;Patients;peripheral blood;Play;pre-clinical;Predisposition;Property;Radiation;radiation delivery;Radiation Dose Unit;radiation effect;Radiation therapy;Radioactive;Radioisotopes;Radiolabeled;Radionuclide therapy;Regulatory T-Lymphocyte;response;Risk;Role;Scanning;side effect;Site;Spleen;Stimulator of Interferon Genes;synergism;Testing;theranostics;Therapeutic;Time;Toxic effect;Translating;treatment optimization;tumor;tumor immunology;tumor microenvironment;Tumor Tissue;Tumor-infiltrating immune cells;uptake;vector;Vision

PROJECT_TITLE: Novel Molecular Targeted Radionuclide Therapies for Dosimetry-Guided Immunomodulation


NIH_SPENDING_CATS: Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE Major pregnancy complications such as preeclampsia, preterm labor and intrauterine growth restriction (IUGR) are leading causes of maternal/fetal morbidity and mortality in the US and worldwide. Immune cell dysregulation in the maternal reproductive tract are thought to be involved in the development of these conditions, but how the immune population in the uterus is regulated is poorly understood. We will develop novel approaches to study the trafficking of immune cells between the blood and the maternal-fetal interface in pregnant rhesus macaques to establish how a healthy immune population is established in the uterus in pregnancy.

PI_NAMEs: STANIC-KOSTIC, ALEKSANDAR  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: angiogenesis;Apoptosis;Applications Grants;Architecture;Blood;Blood Cells;Cell Death;Cell Proliferation;Cells;Chemotaxis;Clinical;clinically actionable;Communicable Diseases;Decidua;Development;Diagnostic;diagnostic development;early pregnancy;Embryo;Endometrial;Endometrium;Equilibrium;experience;Exploratory/Developmental Grant;fetal;Fetal Growth;Fetal Growth Retardation;Fetus;Growth Factor;Hematopoietic stem cells;Hemochorial Placental Development;Human;Immune;immune function;Immune Tolerance;Immunologics;in vivo;Infectious Agent;insight;Intelligence;interest;Knowledge;Leukocytes;Listeria monocytogenes;Luteal Phase;Lymphocyte;lymphocyte trafficking;Lymphoid;Macaca;Macaca mulatta;Maintenance;Maternal-Fetal Exchange;Menstrual cycle;Methodology;Modeling;Morbidity - disease rate;mortality;mucosal site;Mucous Membrane;Natural Killer Cells;nonhuman primate;novel;novel strategies;Organ Transplantation;peripheral blood;Peripheral Blood Lymphocyte;Phenotype;Placenta;Population;Population Dynamics;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnant;Premature Labor;Preparation;pressure;Production;Proliferating;Regulatory T-Lymphocyte;Reproductive Immunology;reproductive tract;Research;Research Project Grants;Research Support;residence;Residencies;response;Risk;Role;Side;Site;Solid;Spiral Artery of the Endometrium;Stains;Surface;Techniques;Testing;Therapeutic;therapeutic target;Tissues;tool;trafficking;Translating;trophoblast;United States National Institutes of Health;Uterus;Zika Virus

PROJECT_TITLE: Gestationally driven trafficking of decidual lymphocytes assessed by serial intravascular staining

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

PHR: PROJECT NARRATIVE To improve patient health and prevent healthcare associated infections (HAIs) due to antibiotic resistant organisms (AROs), it is critical to prevent the transmission and acquisition of AROs from the hospital environment to vulnerable patients. Our work will address these issues by 1) leveraging an established biospecimen repository of AROs isolated from both patients and the intensive care room (ICU) environment to define ARO transmission between the hospital environment and patients, and 2) by implementing and evaluating environmental hygiene strategies to reduce ARO burden in the ICU environment. This project will lead to better, more targeted approaches to preventing ARO transmission and preventing HAIs.

PI_NAMEs: BURNHAM, CAREY-ANN DAWN;DANTAS, GAUTAM ;KWON, JENNIE H (contact)

PROGRAM_OFFICER_NAME: HENDERSON, SUSAN

PROJECT_TITLE: Environmental hygiene strategies to decrease the burden of antibiotic-resistant organisms in Intensive Care Unit SINKs (ICU SINK)

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Radiation Oncology

PHR: PROJECT NARRATIVE – PROJECT 2 Metastatic cancers are typically incurable, despite advances in cancer treatments including immunotherapies, and to begin changing this we propose to develop and investigate a new treatment approach that combines the most common form of immunotherapy (immune checkpoint inhibitors) with targeted radionuclide therapy. Radiation can damage tumors in a way that renders them more responsive to immunotherapies, however conventional radiation therapy typically cannot treat all tumor sites in patients with metastatic disease because of toxicities and the inability to target small tumors that are not identified on imaging scans. Targeted radionuclide therapies injected into a patient’s vein go throughout the body to preferentially deliver radiation to tumors wherever they are located and here we will (1) determine the effect of this type of treatment on the susceptibility of tumors to immune response; and (2) test the effectiveness of this type of treatment when combined with the most common form of immunotherapy in order to determine which combinations should be most beneficial in patients with metastatic cancer.

PI_NAMEs: MORRIS, ZACHARY SCOTT (contact)

PROJECT_TERMS: 90Y;Abbreviations;Affect;Alpha Particles;anti-CTLA4;anti-PD-1;anti-tumor immune response;Antigen Presentation;Antigens;Antitumor Response;Beta Particle;Cancer Patient;cancer therapy;Cells;checkpoint inhibition;Clinical Research;Clinical Sensitivity;Clinical Trials;clinically relevant;Clonal Expansion;Controlled Study;Cytoplasm;Disease;Disseminated Malignant Neoplasm;Dose;Dose Rate;ds-DNA;effectiveness testing;Electrons;External Beam Radiation Therapy;Feedback;follow-up;Gamma Rays;Gene Expression Profiling;Generations;Genetically Engineered Mouse;Goals;Half-Life;Image;Immune;Immune checkpoint inhibitor;Immune response;Immune system;immunogenic cell death;Immunologic Memory;Immunologics;immunoregulation;Immunotherapy;improved;in situ vaccine;in vivo;Individual;Inflammation;insight;Interferon Type I;Interferons;Linear Energy Transfer;Location;Malignant neoplasm of prostate;Measurement;Mediating;Melanoma;Modeling;Molecular Target;Monitor;multidisciplinary;Mus;neoplastic cell;Neuroblastoma;next generation;novel therapeutic intervention;Organism;Outcome;Pathway interactions;Patients;preclinical study;Predisposition;Production;prospective;Radiation;Radiation therapy;Radioactive;Radioisotopes;radiological imaging;Radionuclide therapy;Regulatory T-Lymphocyte;research clinical testing;response;Scanning;Site;Stimulator of Interferon Genes;T cell clonality;T cell response;T-cell receptor repertoire;targeted treatment;Testing;Therapeutic;Three Prime Repair Exonuclease 1;Toxic effect;Translations;Treatment Protocols;TREX1 gene;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;Variant;vector;Veins;Virus Diseases;Whole-Body Irradiation

PROJECT_TITLE: Molecular Targeted Radionuclide Therapy to Enhance Tumor Cell Susceptibility and Response to Immune Checkpoint Inhibition


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cardiovascular;Diabetes;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Kidney Disease;Social Determinants of Health

ORG_CITY: SILVER SPRING

ORG_NAME: NATIONAL MEDICAL ASSOCIATION

ORG_STATE: MD

PHR: This program is designed to foster the research pipeline of underrepresented trainees and early career investigators examining the barriers and root causes behind health disparities through mentorship and through the opportunity to participate in a national scientific conference focused on these issues. The results of increased health disparities/health determinants research -- particularly among underrepresented communities -- may ultimately lead to improved population and community health, which is safer, more accessible, affordable, and equitable.

PI_NAMEs: DOKUN, AYOTUNDE OLUROPO (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Academia;Address;Area;Award;Awareness;Cardiology;career;Communities;Community Health;design;Development;Diabetes Mellitus;early awareness;Endocrinology;Equity;experience;Exposure to;Faculty;Family Practice;Fostering;Future;Gastroenterology;Grant;Grooming;health determinants;health disparity;health equity;HIV/AIDS;improved;interest;Internal Medicine;Leadership;Learning;lectures;medical specialties;Medicine;meetings;member;Mentorship;Metabolism;Minority;minority trainee;Nephrology;next generation;Oncology;Oral;Participant;Physician Executives;Physicians;population health;Positioning Attribute;posters;programs;Public Health;Pulmonology;Research;Research Personnel;Secure;senior faculty;success;symposium;tenure track;tool;Training;Travel;Vocational Guidance;Woman

PROJECT_TITLE: This proposed R13 application will focus on Endocrinology, Diabetes and Metabolism, HIV/AIDS, Gastroenterology, Cardiology, Pulmonology, Nephrology, and Oncology subspecialty topics.


PI_NAMEs: GEULA, CHANGIZ  (contact)

PROJECT_TERMS: Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Basic Science;Behavioral;Biological Phenomena;Career Choice;Clinical;Clinical Research;Clinical Sciences;Compensation;Dedications;Dementia;design;Development;didactic education;Discipline;education research;Educational process of instructing;Educational Status;experience;Exposure to;Faculty;Future;Goals;graduate school;Heterogeneity;improved;Infrastructure;innovation;insight;Interdisciplinary Study;Intervention;Investigation;Knowledge;Medical center;medical schools;Mentors;Mentorship;Modality;multidisciplinary;Neurosciences;Postdoctoral Fellow;Process;programs;recruit;Research;Research Personnel;Research Project Summaries;Research Support;Research Training;responsible research conduct;Scientist;senior faculty;skills;Solid;Students;Time;Training;Training and Education;Translating;Translational Research;Underrepresented Minority;Universities;Work

PROJECT_TITLE: Research Education Component


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Activity;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: CINCINNATI

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Even after rehabilitation, few stroke survivors are able to walk fast and long enough to complete normal daily activities, and poor aerobic fitness is a major barrier to recovery. This proposal will test a promising new rehabilitation strategy called high-intensity interval training that has the potential to yield greater improvements in walking function and aerobic fitness in less time than currently available methods.

PI_NAMEs: BOYNE, PIERCE  (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Address;Adverse event;Aerobic;Aerobic Exercise;Attention;Award;Belief;Blinded;Cardiac rehabilitation;Chronic Phase;chronic stroke;Clinical;clinical care;clinical practice;Clinical Trials;COVID-19;Data;disability burden;Dose;Enrollment;Evidence based treatment;Exercise;Exercise Test;Exertion;Fatigue;follow-up;Funding;Future;Gait abnormality;Government;Guidelines;Heart Rate;Human Resources;Impairment;improved;Individual;individual patient;Infrastructure;innovation;interest;Interruption;Interval training;Intervention;Knowledge;Life;Locomotor training;Measures;meter;Methods;Modeling;Monitor;Neurologic;novel;Outcome;Participant;patient subsets;Patients;Persons;physical therapist;Physiological;post stroke;Process;Prognosis;Protocols documentation;Quality of life;Randomized;Recommendation;Recovery;rehabilitation strategy;Rehabilitation therapy;Research;Resources;response;Risk;Role;Safety;Sampling;Science;Signal Transduction;Single-Blind Study;Site;Speed;Statistical Data Interpretation;Stroke;stroke rehabilitation;stroke survivor;stroke trials;Subgroup;Testing;Time;Training;Training Programs;trial comparing;vigorous intensity;Waiting Lists;Walking;walking speed;Withdrawal

PROJECT_TITLE: High-Intensity Interval Training to Recover Walking Post-Stroke: HIT-Stroke Trial 2

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Neurosciences;Rehabilitation;Sleep Research;Stroke

ORG_DEPT: NEUROLOGY

PHR: The research aims proposed in this application focus on a better understanding of the role of slow wave sleep in post-stroke recovery, the leading cause of adult disability in the US with annual incidence of 800,000 and with over 7 million stroke survivors. This research has the potential to clarify the basic mechanisms of how slow wave sleep regulates neuronal repair and recovery after stroke. Ultimately, this knowledge may identify novel therapies that could enhance recovery after stroke, which would greatly improve health for patients, reduce disability, and enrich quality of life.

PI_NAMEs: LANDSNESS, ERIC C (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acceleration;Acute;Adult;Affect;Animals;Area;Award;Basic Science;Behavior;Behavioral;Binding;Blood Vessels;Brain;Brain Injuries;brain repair;Brain Stem;career;career development;Caring;Cell Nucleus;clinical translation;Collaborations;Communities;Data;designer receptors exclusively activated by designer drugs;Development;disability;Doctor of Philosophy;effective intervention;Electrophysiology (science);Engineering;Environment;Exhibits;experience;experimental study;Faculty;fluorescence imaging;functional improvement;Future;Generations;Genetic;genetic manipulation;Goals;Health;Hour;Human;Hypothalamic structure;Image;imaging modality;Imaging Techniques;improved;in vivo imaging;Incidence;Individual;Infarction;Injury;innovation;interest;Interneurons;Ischemia;Ischemic Brain Injury;K-Series Research Career Programs;Knowledge;Learning;Long term disability;Long-Term Potentiation;Maps;Measures;Mediating;Mediator;Memory;Mentors;Mentorship;Molecular;molecular marker;Monitor;mouse model;Mus;Neocortex;Nervous System Disorder;neural repair;neuroimaging;Neurologist;neuronal circuit disruption;neuronal circuitry;Neuronal Injury;Neurons;Neurosciences;novel therapeutic intervention;novel therapeutics;Optics;Outcome;Patients;pharmacologic;Physicians;Play;post stroke;Process;Quality of life;Recovery;Recovery of Function;Rehabilitation therapy;release of sequestered calcium ion into cytoplasm;repaired;Reproducibility;Research;Research Technics;Role;Scientist;Shapes;Sleep;Sleep Deprivation;Slow-Wave Sleep;Somatosensory Cortex;Speech;Stroke;stroke model;stroke recovery;stroke survivor;success;Synapses;Synaptic plasticity;synaptogenesis;targeted treatment;Testing;Thalamic structure;Therapeutic;Therapeutic Intervention;therapeutic target;Time;Training;United States;Universities;Wakefulness;Washington

PROJECT_TITLE: Local slow wave sleep in repair and recovery after stroke

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

PHR: PROJECT NARRATIVE – PROJECT 3 We are developing a new approach, representing a dramatic shift in the treatment of high-risk pediatric and adult cancers. Our strategy utilizes immune responses to recognize and destroy cancer (immunotherapy) in combination with low-dose radiation therapy, which substantially improves the anti-tumor potency of the immunotherapy regimens we are creating. In our novel approach, we will administer a low-dose, targeted radionuclide that can be injected into a vein and preferentially deliver molecular radiotherapy to primary, local, and distant tumors throughout the body. We will combine this with immunotherapy approaches in mouse models of different childhood cancers to determine which combinations may lead to the most beneficial strategies to cure high-risk pediatric and adult cancers in humans and advance the National Cancer Institute’s mission to help people live longer, healthier lives.

PI_NAMEs: SONDEL, PAUL M (contact)

PROJECT_TERMS: 90Y;adaptive immunity;Adult;Ambulatory Care;analog;Antibodies;Antigens;Biological Models;Biology;Blood;Cancer Patient;cancer site;checkpoint inhibition;Child;Childhood;Clinical;clinical translation;Combination immunotherapy;curative treatments;Differentiation Antigens;Distant;Dose;Effector Cell;effector T cell;Elements;Epitope spreading;External Beam Radiation Therapy;fetal;Generations;Goals;high risk;Histologic;Human;IL2 gene;Immune;immune cell infiltrate;Immune checkpoint inhibitor;immune clearance;Immune response;Immune Tolerance;Immunocompetent;Immunologics;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;in situ cancer vaccination;in situ vaccination;in situ vaccine;in vivo;individual patient;Infiltration;Injections;insight;lead candidate;Local Therapy;Low Dose Radiation;lymph nodes;Malignant Childhood Neoplasm;Malignant Neoplasms;Melanoma;Melanoma Tumor;metaiodobenzylguanidine;Micrometastasis;Mission;Modeling;Molecular;Molecular Analysis;Molecular Target;Monoclonal Antibodies;mouse model;Mus;Mutation;MYCN gene;National Cancer Institute;Natural Immunity;neoantigens;Neoplasm Metastasis;neoplastic cell;Neuroblastoma;novel;novel strategies;Oncogenic;overexpression;Pathway interactions;Patient Isolation;Patients;Pattern;Persons;Phosphorylcholine;pre-clinical;prevent;Primary Neoplasm;Privatization;Radiation therapy;Radioisotopes;Radionuclide therapy;reconstitution;Recurrent tumor;Refractory;refractory cancer;Regimen;Regulatory T-Lymphocyte;Relapse;research clinical testing;Resistance;response;Sarcoma;Site;Specimen;Spleen;synergism;T cell infiltration;T cell response;T memory cell;targeted delivery;Testing;Therapeutic;therapy resistant;Tissues;Transgenic Organisms;Translating;Translations;Transplantation;treatment effect;tumor;Tumor Antigens;Tumor Escape;tumor microenvironment;tumor-immune system interactions;Universities;uptake;vector;Veins;virtual;Vision;Wisconsin;Xenograft procedure

PROJECT_TITLE: Combining targeted radionuclide therapy with  a localized in situ vaccine to overcome immune suppression in the tumor microenvironment and augment T cell responses


ADMINISTERING_IC: HG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SANTA CRUZ

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: PROJECT NARRATIVE The UCSC Graduate Program in Genome Science is designed to train the next generation of scientific leaders in genome sciences, a discipline that is critical to development of new therapies—from cancer to heritable disease. UCSC has been a leader in genomics research since the field was founded and offers a rich interdisciplinary genomics training environment. Our program spans 26 training faculty from 8 departments and combines formal training in statistics, programming, and engineering with more traditional disciplines, such as molecular biology and genetics.

PI_NAMEs: BROOKS, ANGELA NORIE;VOLLMERS, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: genome sciences;programs

PROJECT_TITLE: UCSC Graduate Program in Genome Sciences


NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases;Lung

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Aspergillus fumigatus is a ubiquitous inhaled mold that causes devastating infections in immunocompromised patients, even with receipt of contemporary antifungal drugs. The goal of this proposal is to integrate two novel regulatory circuits that involve lung endothelial and epithelial cells as well as plasmacytoid dendritic cells in a comprehensive model of anti-Aspergillus innate immunity in the lung. Our findings should give rise to novel strategies for enhancing immune function against this fungal pathogen.

PI_NAMEs: HOHL, TOBIAS M (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Amplifiers;anti-fungal agents;Aspergillosis;Aspergillus;Aspergillus fumigatus;Binding;Bone Marrow Transplantation;candidate identification;Cell Death;Cell Death Process;Cells;cellular targeting;chemokine receptor;COVID-19 patient;CXC Chemokines;CXCL10 gene;cytokine;Data;Death Rate;Defect;Dendritic Cells;Disease;Elements;Endothelial Cells;Endothelium;Epithelial Cells;Epithelium;Etiology;Eukaryota;experimental study;Fright;Funding;fungus;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Hematologic Neoplasms;high risk population;Host Defense;Human;Hyphae;Immune;immune checkpoint;immune function;Immune response;Immune system;Immunity;Immunocompetent;Immunocompromised Host;improved;Individual;Infection;inflammatory milieu;Inhalation;innate immune function;Innate Immune System;innovation;Intensive Care Units;Interferons;Interleukin-1 Receptors;interleukin-23;Knowledge;Lead;Ligands;Lung;Lung Transplantation;Mediating;Mediator;Metabolism;Modeling;Molds;Molecular;Molecular Target;monocyte;Mucous Membrane;Mycoses;Myelogenous;Myeloid Cells;NADPH Oxidase;Natural Immunity;neutrophil;novel;novel strategies;Outcome;Oxidases;Participant;pathogen;pathogenic fungus;Patients;Pentosephosphate Pathway;Phagocytes;Pilot Projects;Pneumonia;prevent;Production;Property;Proteomics;receptor;Receptor Signaling;recruit;Regulation;Reporting;Reproduction spores;respiratory;Role;Shapes;Signal Transduction;Source;System;Testing;Therapeutic;Tissues;transcriptomics;Transplant Recipients;Visualization;Work

PROJECT_TITLE: INITIATION OF THE IMMUNE RESPONSE TO ASPERGILLUS FUMIGATUS

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Cancer;Immunization;Immunotherapy;Prevention;Prostate Cancer;Radiation Oncology;Urologic Diseases;Vaccine Related

PHR: PROJECT NARRATIVE – PROJECT 4 We have recently identified that targeted radionuclide therapy (TRT) at doses lower than those that cause direct anti-tumor effects and in combination with anti-tumor vaccination can elicit greater anti-tumor effects than either treatment alone. Given that both of these approaches are in clinical testing as treatments for prostate cancer, an immunologically “cold” tumor, this project focuses on combinations of anti-tumor vaccination with low dose TRT as treatments for prostate cancer. The goals of this project are to understand the impact of these treatments on antigen-specific tumor-infiltrating CD8+ T cells to understand optimal treatment approaches that can be evaluated in future human clinical trials for the treatment of human prostate cancer, which will ultimately advance the National Cancer Institute’s mission to help people live longer, healthier lives.

PI_NAMEs: MCNEEL, DOUGLAS G. (contact)

PROJECT_TERMS: 90Y;advanced prostate cancer;androgen deprivation therapy;Androgen Receptor;Androgens;Antigens;antitumor effect;Antitumor Response;Binding;Binding Sites;Bioinformatics;Brachytherapy;cancer infiltrating T cells;cancer type;cancer vaccination;Cancer Vaccines;Castration;CD8-Positive T-Lymphocytes;Cells;chelation;Clinical Treatment;Clinical Trials;Cytolysis;Data;deprivation;design;Disease;DNA Vaccines;Dose;dosimetry;Evaluation;External Beam Radiation Therapy;FDA approved;FOLH1 gene;Future;Goals;Health;Human;Image;immune cell infiltrate;Immune checkpoint inhibitor;immune function;Immunity;Immunologics;immunoregulation;Immunotherapy;improved;in vivo;Infiltration;inhibitor;interest;Interferon Type II;Isotopes;Ligand Binding Domain;LNCaP;Local Therapy;lymph nodes;male;Malignant neoplasm of prostate;Malignant Neoplasms;Metals;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Mission;Modeling;Molecular Target;mouse model;Mus;Myeloid-derived suppressor cells;National Cancer Institute;Neoplasm Metastasis;neoplastic cell;next generation;Normal Cell;novel;optimal treatments;palliative;Pathway interactions;Patients;Pattern;PC3 cell line;Persons;Phase I Clinical Trials;Population;Predisposition;Production;programmed cell death ligand 1;prostate cancer cell line;prostate cancer model;prostate cancer progression;Prostate Cancer therapy;Prostatic Neoplasms;Proteins;Radiation Dose Unit;Radiation therapy;Radioimmunoconjugate;Radiolabeled;Radionuclide therapy;Radium;Recurrence;research clinical testing;Resistance;response;Series;small molecule;T cell infiltration;T-Cell Activation;T-Lymphocyte;Testing;Time;Tissues;Toxic effect;Transgenic Organisms;tumor;Tumor Antigens;Tumor Expansion;tumor microenvironment;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Vaccination;Vaccines;vector;Work;Xenograft procedure

PROJECT_TITLE: Molecular Targeted Radionuclide Therapy with Tumor-Specific Vaccine to Stimulate and Expand T-cell Activation


ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA STATE UNIVERSITY

PHR: NARRATIVE Acute kidney injury is a medical condition that complicates ~20% of all hospital admissions and is a strong predictor of mortality. In this study, we aim to develop pharmaceutically acceptable forms of CO for the treatment of acute kidney injury caused by surgery, trauma, crush, or other forms injuries.

PI_NAMEs: DE CAESTECKER, MARK P.;OTTERBEIN, LEO E;WANG, BINGHE  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Affect;allotransplant;Animal Model;Animals;Biological;Biology;Carbon Monoxide;Cardiopulmonary Bypass;Chemistry;Chronic Kidney Failure;Clinical;Colon;Crush Injury;Cytoprotection;delayed graft function;design;Development;Disease;Donor person;Dose;drug discovery;Drug Kinetics;efficacy evaluation;efficacy validation;Event;Exposure to;Family suidae;FDA approved;Formulation;Foundations;Future;Goals;Grant;Heme;Hemeproteins;Hemolysis;Hospitalization;Human;Hypotension;improved;improved outcome;in vitro Assay;in vitro Model;Incidence;Industrialization;Inflammation;Injury;Injury to Kidney;innovation;interest;Intervention;Kidney;Kidney Transplantation;Kinetics;Lead;Literature;Liver;liver injury;Maintenance Therapy;Medical;Mississippi;Mitochondria;Modeling;mortality;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nitric Oxide;novel;Operative Surgical Procedures;Organ;organ injury;Organ Model;Outcome;Oxidative Stress;Pancreas;Patients;Pharmaceutical Chemistry;pharmacologic;Pharmacology;pill;Plasma;porcine model;pre-clinical;pre-clinical assessment;prevent;Prodrugs;Property;protective effect;renal ischemia;Reperfusion Injury;response;Rhabdomyolysis;Role;Route;Safety;safety assessment;scaffold;Sepsis;Series;Severities;Sickle Cell Anemia;Signal Transduction;Signaling Molecule;Stomach;success;Supportive care;Synthesis Chemistry;systemic inflammatory response;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;tissue injury;Tissues;Toxic effect;Translating;transplant model;Transplant Recipients;Trauma;Treatment Efficacy;Validation;validation studies;Warm Ischemia;Work

PROJECT_TITLE: Early-Stage Preclinical Validation of Carbon Monoxide Prodrugs for Acute Kidney Injury


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Volume-regulated anion channels (VRACs) are plasma membrane proteins that perform essential physiological functions. VRACs and the genes that encode them are implicated in multiple diseases including diabetes, obesity, cancer, and immunity. Our proposed studies utilize a novel chimeric approach to better define VRAC structure-function relationships, which are essential for understanding VRAC associated diseases and developing new drugs that specifically modify VRAC activity.

PI_NAMEs: DENTON, JEROD S. (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: Amino Acids;Anions;Aromatic Amino Acids;Cell membrane;Cell Volumes;Cells;Charge;Chimera organism;Cryoelectron Microscopy;Diabetes Mellitus;Disease;Electrophysiology (science);Foundations;Funding;Gene Family;Genes;Goals;Immunity;inhibitor;insight;Interleukin-1;Ionic Strengths;Laboratories;Malignant Neoplasms;Mediating;member;Membrane Proteins;Molecular;Molecular Conformation;Mutagenesis;Nature;non-Native;novel;novel therapeutics;Obesity;particle;patch clamp;Physiological;Physiological Processes;Play;Property;Proteins;Regulation;Resolution;RNA interference screen;Role;Sodium Chloride;solute;stoichiometry;Structure;Structure-Activity Relationship;Swelling;Testing;Translating;whole genome

PROJECT_TITLE: Structure-function analysis of the volume-regulated anion channel VRAC using novel LRRC8 chimeras

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


PHR: PROJECT NARRATIVE - ADMINISTRATIVE CORE The Project Narrative is not required for the Administrative Core as per the PAR-18-290 Funding Opportunity Announcement.

PROJECT_TERMS: Adherence;Administrative Coordination;Advisory Committees;animal care;Award;Cancer Center;Chemicals;Communication;Communication Programs;Complex;Development;Doctor of Philosophy;Ensure;Expenditure;experience;Fostering;Funding;Funding Opportunities;Future;Goals;Grant;Guidelines;Hygiene;immunoregulation;Immunotherapy;Institution;Laws;Leadership;meetings;Mission;Molecular Target;Monitor;National Cancer Institute;organizational structure;Policies;Principal Investigator;programs;Radiation;Radionuclide therapy;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;response;Safety;Services;Structure;Time;timeline;tumor;Universities;Vertebral column;web site;Wisconsin


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Infectious Diseases;Pediatric

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative The EvolvingSTEM program will use a research-education partnership to educate high school introductory biology students about evolutionary biology, microbiology, and their impact on human health using authentic experimentation and 21st century bioinformatic skills. It has broad potential for increasing understanding of evolution, an important, yet widely misunderstood, life science concept, which will improve public literacy of its role in biomedical advances and public health. The findings from our proposal will improve design and implementation of research experiences that expose high school students (including those from underrepresented groups) to research methods and concepts that are not typically available in conventional classroom activities, and determine whether particular interventions (e.g., near-peer mentorship, student-driven inquiry) lead to sustained engagement in STEM and pursuit of STEM-related careers.

PI_NAMEs: COOPER, VAUGHN  (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Agar;American Association for the Advancement of Science;Antimicrobial Resistance;Attitude;Award;Bacteria;Bioinformatics;Biological Sciences;Biology;Biotechnology;career;causal variant;chronic infection;classroom research;cloud based;Data;Data Science;design;disadvantaged student;economic disparity;education research;Educational Curriculum;Educational process of instructing;empowerment;Epidemiology;Equipment;Evolution;expectation;experience;experimental study;Familiarity;fitness;Focus Groups;follow-up;Genetic;genome sequencing;genomic data;Goals;graduate student;Group Interviews;Growth;Health;Health Sciences;Heritability;high school;High School Student;Human;Human Microbiome;improved;Infection;Instruction;interest;Intervention;Investigation;Knowledge;Laboratories;laboratory curriculum;laboratory experience;laboratory experiment;Laboratory Research;Lead;Learning;Learning Disabilities;literacy;Measures;Medicine;Mentorship;Methods;Microbe;Microbial Biofilms;Microbiology;Mission;Modeling;Modernization;Motivation;multisensory;Mutation;offspring;opportunistic pathogen;Outcome;Parents;pathogen;pathogenic bacteria;Patient Self-Report;peer;peer coaching;peer networks;Performance;Phenotype;Productivity;programs;Pseudomonas fluorescens;Public Health;Reproducibility;Research;Research Methodology;Research Personnel;Role;school district;Schools;science education;Scientist;skill acquisition;skills;STEM career;student participation;Students;Surface;Surveys;System;teacher;Technical Expertise;Testing;Time;Uncertainty;undergraduate student;Underrepresented Minority;Underrepresented Populations;Visual;whole genome;Work;young woman

PROJECT_TITLE: EvolvingSTEM: authentic classroom research curriculum to enhance inclusion and agency in modern life science

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


PHR: PROJECT NARRATIVE - RADIONUCLIDE PRODUCTION AND RADIOCHEMISTRY CORE 1 The Radiouclide Production and Radiochemistry Core (RPRC) will provide the unique radionuclides coupled to targeting agents necessary for the P01 Projects 1 through 4 to investigate the symbiotic effect of tailored radiation dose delivery and immunological therapies in cancer therapy. Radionuclide production using the versatile accelerator targetry and radiochemical separation strategies in combination with novel pharmacological targeting methods will enable versatile, image-derived dosimetry and treatment using a broad palette of physical decay mechanisms and in vivo localization strategies.

PI_NAMEs: ENGLE, JONATHAN W (contact)

PROJECT_TITLE: Radionuclide Production and Radiochemistry Core Description Core


ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative This application seeks to continue long-standing support for the UCSD Medical Scientist (M.D./Ph.D.) Training Program (MSTP), which combines both M.D. (through an Integrated Scientific Curriculum in the UCSD School of Medicine) and Ph.D. training in areas of the biomedical sciences, including cellular and molecular biology, neuroscience, and bioengineering. Excellent trainees are recruited throughout the United States and graduates typically pursue careers as academic physician scientists. This MSTP has evolved through not only expanding research opportunities and support at UCSD and affiliated institutions (Salk Institute for Biological Sciences and the Scripps Research Institute) but also growing a pool of diverse, high quality applicants and faculty.

PI_NAMEs: CHI, NEIL C;INSEL, PAUL A (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


PHR: PROJECT NARRATIVE - ADVANCED IMAGING AND DOSIMETRY CORE 2 The Advanced Imaging and Dosimetry Core (AIDC) will provide dedicated expertise and cost-efficient support required to facilitate quantitative multiscale imaging and dosimetry calculations for the P01 application, “Molecular Targeted Radionuclide Therapy for Tumor Immunomodulation and Enhancing Immunotherapy Response.” This centralized dosimetry service core is critical for the P01 to achieve its overarching research goals of 1) developing a broad mechanistic understanding of the immunomodulatory capacity of molecular targeted radionuclide therapy (TRT) and 2) evaluating TRT as part of the next generation immunotherapy approaches to improve the treatment of immunologically “hot” and “cold” tumors.

PI_NAMEs: BEDNARZ, BRYAN PATRICK (contact)

PROJECT_TERMS: 3-Dimensional;absorption;animal imaging;Animals;Bioinformatics;Biometry;Calibration;Cancer Center;Cancer Model;Clinical;clinical translation;Collaborations;Combined Modality Therapy;Communities;companion animal;Computational algorithm;Computer software;cost efficient;Data;Dedications;Deposition;Discipline of Nuclear Medicine;Dose;dosimetry;drug distribution;Drug Kinetics;Emission-Computed Tomography;Ensure;Equipment;experience;Experimental Designs;Funding;Goals;Human;Image;Image Analysis;imaging facilities;Immunologic Stimulation;Immunologics;immunomodulatory strategy;immunoregulation;Immunosuppression;Immunotherapy;improved;Individual;individualized medicine;Infrastructure;Lead;Leadership;Magnetic Resonance;Malignant Neoplasms;Maps;Medical;Medical Research;Modeling;Molecular Target;National Cancer Institute;next generation;Normal tissue morphology;operation;optical imaging;Patient Selection;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physics;Positron-Emission Tomography;Process;Production;professor;Protocols documentation;Publications;quality assurance;Quality Control;quantitative imaging;Radiation therapy;Radiochemistry;Radioisotopes;Radionuclide therapy;Radiopharmaceuticals;Renaissance;Reporting;Research;Research Personnel;Resources;response;Rodent;Scanning;Services;symposium;synergism;theranostics;Therapeutic;Time;Toxic effect;Translating;Treatment Efficacy;treatment planning;treatment response;tumor;tumor microenvironment;Tumor Tissue;Uncertainty;United States Food and Drug Administration;University of Wisconsin Comprehensive Cancer Center;University resources;Wisconsin;X-Ray Computed Tomography

PROJECT_TITLE: Advanced Imaging and Dosimetry Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Networking and Information Technology R&D (NITRD);Radiation Oncology

PHR: PROJECT NARRATIVE – BIOSTATISTICS AND BIOINFORMATICS CORE 3 The Biostatistics and Bioinformatics Core will provide dedicated expertise and cost-efficient support in biostatistics, bioinformatics, and research data management for the P01 application, “Molecular Targeted Radionuclide Therapy for Tumor Immunomodulation and Enhancing Immunotherapy Response.” This data science core is critical for the P01 to achieve its overarching research goals of 1) developing a broad mechanistic understanding of the immunomodulatory capacity of molecular targeted radionuclide therapy (TRT) and 2) evaluating TRT as part of the next generation immunotherapy approaches to improve the treatment of immunologically “hot” and “cold” tumors, and ultimately advance scientific knowledge and help all people live longer, healthier lives.

PI_NAMEs: KIM, KYUNGMANN  (contact)

PROJECT_TERMS: Animals;Archives;Bioinformatics;Biology;Biomedical Research;Biometry;Biostatistical Methods;Cancer Patient;canine model;Canis familiaris;Clinical Trials;Collaborations;Communities;comparative;Consultations;cost efficient;Data;Data Analyses;Data Collection;data hub;data management;Data Science Core;data standards;Database Management Systems;Databases;Dedications;dosimetry;Ensure;Experimental Designs;experimental study;Faculty;Formulation;Goals;Human;Image;Immunologics;immunoregulation;Immunotherapy;improved;Information Dissemination;interoperability;Knowledge;Laboratories;Malignant Neoplasms;Molecular Target;mouse model;Mus;Nature;next generation;patient derived xenograft model;Persons;pre-clinical;Production;Program Research Project Grants;Publications;quality assurance;Quality Control;Radiochemistry;Radioisotopes;Radionuclide therapy;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;research study;Research Support;response;Scientific Advances and Accomplishments;Secure;single cell sequencing;single-cell RNA sequencing;Standardization;Statistical Data Interpretation;Statistical Models;T cell receptor repertoire sequencing;T-Cell Receptor;transcriptome sequencing;Translating;Translational Research;tumor;tumor eradication;usability;Validation

PROJECT_TITLE: Biostats Core (TBD)


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NEW ORLEANS

ORG_NAME: SOUTHEAST LOUISIANA VETERANS HEALTH CARE

ORG_STATE: LA

PHR: Project Narrative Traumatic stress exposure can lead to long-term stress disorders and represents a considerable risk factor for suicide. Stress disorders such as posttraumatic stress disorder (PTSD) have significant links with suicidality and present an enormous health and financial burden on society. Stress disorders are characterized by plasticity of neural circuits and neurochemical signaling in the amygdala, an emotional center of the brain. We will use genetically engineered mouse models and viral delivery of light- and designer drug-activated channels and receptors to manipulate brain circuits to study inhibitory circuits in the amygdala involved in fear memory formation. We will use a traumatic stress mouse model to determine whether inhibitory circuits in the amygdala undergo long-term changes in response to trauma that lead to stress-associated pathologies.

PI_NAMEs: TASKER, JEFFREY G (contact)

PROJECT_TERMS: Adrenergic Receptor;alcohol use disorder;Amygdaloid structure;Arousal;behavior test;Behavioral Paradigm;Brain;cell type;Cells;Chemosensitization;Cholecystokinin;Cognitive;Complex;desensitization;Designer Drugs;Development;Emotional;Equilibrium;Excitatory Synapse;experimental study;Exposure to;Extinction;fear memory;Feeling suicidal;Financial Hardship;Foundations;Fright;gamma-Aminobutyric Acid;Genetic;genetic approach;Genetically Engineered Mouse;Health;in vivo;insight;Interneurons;Learning;Light;Link;locus ceruleus structure;Measures;Mediating;Memory;memory consolidation;memory process;Modeling;mouse model;Mus;nerve supply;neural;neural circuit;neurochemistry;Neuronal Plasticity;Neurons;neuroregulation;neurotransmission;noradrenergic;Norepinephrine;optogenetics;Output;Parvalbumins;patch clamp;Pathologic;Pathology;Pattern;Phase;Play;Post-Traumatic Stress Disorders;postsynaptic;pre-clinical;preclinical study;presynaptic;Process;Psychopathology;receptor;Regulation;response;Risk Factors;Role;sensory integration;Signal Transduction;Slice;Societies;Source;Stereotyping;Stream;Stress;stress disorder;Structure;suicidal;Suicide;Synapses;synaptic inhibition;Testing;Trauma;traumatic stress;Viral

PROJECT_TITLE: Role of amygdala inhibitory circuit neuromodulation in stress disorders


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Therapies to treat Crohn's disease and ulcerative colitis, the types of inflammatory bowel disease (IBD) characterized by severe chronic inflammation of the gastrointestinal tract, have greatly improved over the past three decades; yet, a large proportion of IBD patients fail to achieve sustained remission. Extensive accumulating data suggest that normalization of LRRK2 (leucine-rich repeat kinase 2) activity may be an attractive therapeutic strategy to treat IBD. We are proposing to develop novel, highly potent, gut-restricted LRRK2 inhibitors and test their tolerance, toxicity, and efficacy using in vitro and in vivo studies.

PI_NAMEs: DEVITA, ROBERT J;PETER, INGA  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: absorption;Affect;Age of Onset;Alleles;analog;Anti-Inflammatory Agents;Attention;Autophagocytosis;Binding;Binding Sites;Biochemical;Biological Assay;Biological Markers;Blocking Antibodies;Brain;Cells;chemical group;Chemicals;Chronic;Circulation;clinical care;Clinical Trials;Code;Colitis;Colonic inflammation;Complex;Crohn's disease;Crystallization;cytokine;Data;Dendritic Cells;design;Development;Disease;disease heterogeneity;Disease remission;disorder risk;Dose;Drug Design;drug development;drug discovery;Drug Kinetics;Drug Targeting;effective therapy;Enzymes;Epithelium;Etiology;Excretory function;Future;gain of function mutation;Gastrointestinal tract structure;General Population;Genes;Genetic Markers;genome wide association study;Goals;improved;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inhibitor;Intellectual Property;interest;interleukin-23;Lead;Link;Location;loss of function;LRRK2 gene;Lung;Medical;Metabolism;Monoclonal Antibodies;Mus;mutant;Mutate;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;nephrotoxicity;novel;Operative Surgical Procedures;Oral;Parkinson Disease;Pathogenesis;Pathogenicity;Pathway interactions;Patient Care;Patients;Penetration;Peripheral;personalized therapeutic;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Plasma;Population;pre-clinical;Pre-Clinical Model;Production;Property;prototype;Research;response;Risk;Roentgen Rays;Safety;safety testing;scaffold;Severities;side effect;Structure;Testing;Therapeutic;therapeutic target;Therapeutic Uses;therapeutically effective;Time;Tissues;TNF gene;Toxic effect;Ulcerative Colitis;Validation;Variant;X-Ray Crystallography

PROJECT_TITLE: Preclinical Validation of Novel Gut-Restricted LRRK2 Inhibitors as Therapeutic Leads for IBD


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Observational data, including electronic health records (EHR) and claims data, provide tremendous opportunities for clinical and translational research for Alzheimer's Disease and Alzheimer's Disease Related Dementia (AD/ADRD). A key challenge is observational AD/ADRD research is to better manage and analyze phenotypic data. This project aims at developing novel informatics methods and tools to manage phenotype definitions and correct bias associated with phenotyping errors on local data, thus enhancing the reproducibility and quality of observational studies on AD/ADRD.

PI_NAMEs: CHEN, YONG  (contact);XU, HUA

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Active Learning;Address;Affect;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;American;Artificial Intelligence;base;care systems;Cause of Death;Clinical Research;cohort;Communities;community engagement;Complex;Data;Data Analyses;data management;Deposition;Disease;Drug Exposure;effective therapy;Electronic Health Record;Engineering;Epidemiologist;Etiology;Evaluation;FAIR principles;Goals;Healthcare;hospital services;improved;Incentives;Incidence;Informatics;insight;Investigation;Joints;Knowledge;Literature;Long-Term Care;Medical;Methods;Modernization;novel;Observational Study;Ontology;Outcome;Pathogenesis;Patients;payment;Phenotype;phenotypic data;phenotyping algorithm;prevent;Prevention;Probability;Protocols documentation;Publication Bias;repository;Reproducibility;Research;Risk Factors;risk stratification;Sampling;social;Source;Standardization;Statistical Models;Terminology;tool;trait;Translational Research;treatment response;web portal

PROJECT_TITLE: TRiPOD: Toward Reusable Phenotypes in Observational Data for AD/ADRD - managing definitions and correcting bias

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pain Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Chronic pain is a leading cause of disability in the US and globally, especially among older adults, yet management options are limited and fundamental knowledge regarding causes and consequences of chronic overlapping pain conditions is lacking. We propose an inter-disciplinary study of chronic overlapping pain conditions in older African American adults who have been understudied in this regard, with a focus on neurophysiologic alterations, healthy lifestyle factors and psychosocial factors as underlying risk factors, and the impact of chronic overlapping pain conditions and neurophysiologic alterations in pain processing on physical and psychosocial function, ability to live independently, and mortality risk. The proposed work will bring new insights into chronic pain as a condition itself regardless of anatomic location of pain, with an aim to help the millions suffering from chronic pain.

PI_NAMEs: BENJAMIN, EMELIA J.;EDWARDS, ROBERT R;NEOGI, TUHINA  (contact);SIMS, MARIO

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: Abdominal Pain;Address;Admission activity;Adult;Affect;African American;African American population;American;American Heart Association;Anatomy;Arthralgia;Back Pain;Body part;Body System;care coordination;Cessation of life;Chronic;chronic pain;chronic painful condition;cohort;Cohort Studies;Communities;conditioned pain modulation;coping;cost estimate;Data;Death Rate;Degenerative polyarthritis;Development;Diagnosis;disability;Disease;Distress;Epidemiologist;Epidemiology;Evaluation;Evolution;follow up assessment;follow-up;Funding;gastrointestinal;Health Personnel;healthy lifestyle;High Prevalence;human old age (65+);Incidence;Individual;innovation;insight;Institutionalization;Interdisciplinary Study;International;Jackson Heart Study;Joints;Knowledge;Life;lifestyle factors;Location;Low Prevalence;Maintenance;Migraine;mortality;mortality risk;multidisciplinary;Musculoskeletal;negative affect;Neurologic;neurophysiology;novel;Nursing Homes;older adult;optimism;Outcome;Pain;Pain management;Pain Measurement;pain processing;Pathway interactions;Patient-Focused Outcomes;Patients;Physical Function;Population;Prevalence;Preventive;Psychologist;psychosocial;Psychosocial Factor;Public Health;racial health disparity;resilience;rheumatologist;Risk;Risk Factors;Sampling;Sensory;Severities;social health determinants;social influence;Social Network;Social support;Specialist;Spirituality;Stress;stressor;surveillance study;System;Testing;Therapeutic;Time;Visit;Work;years lived with disability

PROJECT_TITLE: Pain in community-based older African American Adults: The Jackson Heart Study

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: BLACKSBURG

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Sexual and gender minority (SGM) youth are at higher risk for suicidal ideation and attempts than their heterosexual and cisgender counterparts; yet, this community faces many barriers that complicate the implementation of suicide prevention programs. In this project, we aim to adapt, implement and test an empirically-informed, multicomponent youth suicide prevention program, Behavioral-Health Works, in organizations serving this population. We will evaluate primary program outcomes (increased suicide identification and successful referrals), secondary outcomes (program acceptability), and exploratory program mechanisms (training impact, partnership development, software usability, and caregiver involvement).

PI_NAMEs: RUSSON, JODY MOSER (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Adoption;behavioral health;Caregivers;Caring;Cause of Death;Child;cisgender;Clinic;Clinical;Communities;community organizations;comparison group;Computer software;Consolidated Framework for Implementation Research;Control Groups;Data;Data Analytics;data management;Development;Diamond;Effectiveness;effectiveness/implementation hybrid;Electronics;Elements;evidence base;Face;Family;Feeling;Feeling suicidal;Fishes;Future;gender minority community;gender minority youth;General Population;Health Personnel;Heterosexuals;high risk;hybrid type 2 design;implementation facilitation;implementation strategy;improved;Learning;Lesbian Gay Bisexual Transgender Queer;Manuals;Measures;Mental Health Services;minority patient;Monitor;Outcome;Patients;peer;Philadelphia;pilot test;Policy Developments;Population;Prevention program;Process;Program Acceptability;Program Effectiveness;programs;Provider;Psychiatry;Readiness;Reporting;Research;Resources;Risk Assessment;Risk Management;Rural;Safety;Sampling;satisfaction;screening;Screening procedure;screening, brief intervention, referral, and treatment;secondary outcome;Self Efficacy;service organization;Services;Sexual and Gender Minorities;sexual minority youth;Site;skills;Standardization;Structure;substance use;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;System;Technology;Testing;Time;Training;treatment as usual;Trust;United States;United States Substance Abuse and Mental Health Services Administration;usability;Virginia;Vulnerable Populations;web based software;web platform;Work;Youth

PROJECT_TITLE: The BH-Works Suicide Prevention Program for Sexual and Gender Minority Youth


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Better methods are needed to identify and mitigate any risks of misdiagnosis during telemedicine visits. In this project we will first understand what aspects of telemedicine may involve risks of misdiagnosis, then develop electronic methods to identify telemedicine visits where misdiagnosis may have occurred, and finally use all this knowledge to develop risk assessment guidance tools that health care organizations, providers, and patients can use to reduce any risks of misdiagnosis associated with telemedicine.

PI_NAMEs: MURPHY, DANIEL R (contact);SINGH, HARDEEP

PROGRAM_OFFICER_NAME: COSBY, KAREN

PROJECT_TITLE: Developing e-Triggers to Detect Telemedicine Related Diagnostic Safety Events


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Alcohol use is a common risk factor for both HIV acquisition and poor uptake and use of effective biomedical HIV prevention options, including pre- and post-exposure prophylaxis, in sub-Saharan Africa. This study will test innovative interventions to increase uptake and use of biomedical HIV prevention options by engaging women and men at drinking venues in rural Kenya and Uganda in care and evaluating a brief alcohol counseling intervention among adults with heavy alcohol use at high risk for HIV, while gaining insights into the facilitators, barriers, and cost-effectiveness of these approaches.

PI_NAMEs: CHAMIE, GABRIEL  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Adherence;Adult;Africa South of the Sahara;AIDS prevention;Alcohol consumption;alcohol use initiation;Alcohols;Anti-Retroviral Agents;antiretroviral therapy;arm;Awareness;barrier to testing;Caring;Communities;community setting;compare effectiveness;Consumption;cost effectiveness;cost estimate;Counseling;Country;Data;Disease;drinking;effectiveness measure;Effectiveness of Interventions;effectiveness trial;efficacy evaluation;Face;Health;Heavy Drinking;high risk;HIV;HIV risk;HIV Seropositivity;HIV therapy;Hot Spot;Human immunodeficiency virus test;Incidence;Injectable;innovation;insight;Intervention;Interview;Kenya;men;Oral;Participant;Perception;Persons;phosphatidylethanol;Play;pre-exposure prophylaxis;Prevalence;Prevention;prevention service;primary outcome;Prophylactic treatment;randomized trial;recruit;reduced alcohol use;Research;Risk;Risk Factors;risk perception;Role;Rural;Sampling;screening;secondary outcome;Sexual Partners;Site;social stigma;standard care;Testing;testing uptake;therapy adherence;Time;transactional sex;transmission process;Uganda;Unsafe Sex;uptake;Viral;Woman

PROJECT_TITLE: Innovative strategies to promote biomedical HIV prevention uptake and retention among high-risk adults at drinking venues in Kenya and Uganda


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Age-related macular degeneration (AMD) is the most prevalent cause of visual disability in developed nations. We identified a protein that is involved in the production of leaky blood vessels and scarring in the space beneath the retina, which characterizes the most severe forms of AMD. We will test whether inhibiting the function of this protein reduces new blood vessel growth, leakiness, and scarring and therefore may be a target for the development of new drugs to treat AMD.

PI_NAMEs: HARTNETT, MARY ELIZABETH RUTH;ZHU, WEIQUAN (WENDY)  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Accounting;Adult;Age related macular degeneration;Blindness;Blood Vessels;Bruch's basal membrane structure;Cell Culture Techniques;Cell Lineage;Cells;Choroid;Cicatrix;connective tissue growth factor;cytokine;Data;Degenerative Disorder;Developed Countries;Development;Diagnosis;Disease;drug development;Drug Targeting;Endothelial Cells;Endothelium;Epiretinal Membrane;Epithelial Cells;epithelial to mesenchymal transition;experimental study;extracellular;Exudative age-related macular degeneration;Fibroblast Growth Factor;Fibrosis;Future;Genetic;Growth;Growth Factor;Human;Inflammatory;inhibitor;Interleukin-1;Interleukin-1 beta;Knock-out;Knockout Mice;Lasers;Lesion;Location;macula;Mesenchymal;Modeling;Molecular;Monomeric GTP-Binding Proteins;Motility;mouse model;Myofibroblast;neovascular;neovascularization;Neurodegenerative Disorders;novel therapeutics;Patients;Permeability;Persons;Pharmaceutical Preparations;pharmacologic;Pigment Epithelium;Population;prevent;Production;proliferative diabetic retinopathy;Proliferative Vitreoretinopathy;protein function;Proteins;Publishing;response;Retina;Retinal Neovascularization;Retinopathy of Prematurity;Role;Signal Pathway;single-cell RNA sequencing;Structure of retinal pigment epithelium;Testing;therapy design;Time;TNF gene;Transforming Growth Factor beta;Treatment Factor;Vascular Diseases;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vision;Visual disability;wound healing

PROJECT_TITLE: Inhibiting Neovascularization and Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Some patients’ immune system can be triggered with immunotherapies, leading to their cure. Those patients have a collection of ‘reactive’ immune cells in their tumors, and this proposal will figure out how to support that immune system so that even patients without those cells can be cured.

PI_NAMEs: KRUMMEL, MATTHEW F (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Acinar Cell;Ally;Animals;Area;Biology;Blocking Antibodies;CD8-Positive T-Lymphocytes;CD8B1 gene;cell motility;Cell Physiology;Cell Separation;cell type;Cells;Cellular biology;Collection;comparison control;Competence;Data Set;Dendritic Cells;design;Diagnostic;Disease;Endothelium;Engineering;Epithelium;Fibroblasts;FLT3 ligand;Funding;Gene Expression;gene network;Genes;Genetic;Goals;Grouping;Growth;Growth Factor;Human;human disease;human model;Image;Immune;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunoassay;Immunologics;Immunotherapy;In Vitro;interest;intestinal villi;islet;Knock-out;Lead;Length;Ligands;Light;Liver;Location;lymph nodes;Macrophage;macrophage-derived chemokine;Malignant Neoplasms;Mediating;Melanoma;Methods;Migration Assay;Molecular;monocyte;mouse model;Natural Killer Cells;Pancreas;Patients;Pattern;Phenotype;Population;Positioning Attribute;programs;Reagent;recruit;Research Personnel;response;Role;Signal Pathway;spatiotemporal;Specific qualifier value;Stromal Cells;Systems Biology;T-Cell Activation;T-Lymphocyte;Testing;Tissues;tool;transcriptomics;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Viral;Work

PROJECT_TITLE: The Tumor Microenvironment Niche of Type I conventional Dendritic Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-W(80)S]