ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Dietary Supplements;Genetics;Human Genome;Neurosciences;Nutrition;Pediatric;Prevention;Rare Diseases;Spina Bifida;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE We establish a new basic science-clinical science consortium to assess how arsenic affects the maternal epigenome to increase risk of neural tube defects. We use biological samples collected from an epidemiological study in Bangladesh as well as in vitro methods using cutting-edge technologies, including whole genome bisulfite sequencing DNA methylation arrays. Additionally, we will investigate DNA methylation changes following a short course of high-dose folic acid supplementation among women who had a pregnancy affected by spina bifida.

PI_NAMEs: MAZUMDAR, MAITREYI  (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Acceleration;Address;Adoption;Affect;Anencephaly and spina bifida X linked;Animal Model;Applied Research;Area;Arsenic;autism spectrum disorder;Bangladesh;Basic Science;bead chip;biobank;Biological;Biological Markers;Biometry;bisulfite sequencing;Boston;Brain;California;Child;Chromatin;clinical examination;Clinical Sciences;Collaborations;college;Congenital Abnormality;contaminated drinking water;Country;Death Rate;Development;Developmental Biology;directed differentiation;DNA;DNA Methylation;DNA Sequence;Dose;effective intervention;Embryo;epidemiology study;Epigenetic Process;epigenome;Exposure to;first-in-human;Folic Acid;Folic acid fortification;folic acid supplementation;functional genomics;gene discovery;Gene Expression;Genes;Genetic;Genetic Transcription;Genomic DNA;genomic locus;Goals;Health;high reward;high risk;Hospitals;Human;human embryonic stem cell;in silico;In Vitro;Infant;Intake;interdisciplinary approach;Intervention;Lesion;Leukocytes;Lifelong disability;Live Birth;Measures;Mediating;medical schools;Medicine;Methodology;Methods;Methylation;methylation pattern;Micronutrients;Modeling;Molecular Biology;Molecular Epidemiology;Mothers;Mutation;nerve stem cell;Nervous System;neural;neural plate;Neural Tube Closure;Neural Tube Defects;Neurodevelopmental Disorder;neuroimaging;Neurosciences;neurosurgery;neurotoxicity;nutrition;Operative Surgical Procedures;Outcome;Parents;Pediatric Hospitals;Pediatric Neurology;Persons;Pilot Projects;Population;Pregnancy;Prevalence;prevent;Prevention strategy;preventive intervention;Public Health;Questionnaires;Recording of previous events;Research Activity;Risk;Risk Factors;Sampling;Schizophrenia;Science;Secondary Prevention;Spinal Cord;Spinal Dysraphism;standard of care;success;Supplementation;Technology;Testing;Tissues;Toxic effect;Translations;Universities;whole genome;Woman

PROJECT_TITLE: Interdisciplinary approaches for understanding how arsenic and micronutrients affect the epigenome to influence spina bifida risk


ADMINISTERING_IC: OD

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Not required for this component, per RFA.

PI_NAMEs: ERICSEN, ADAM  (contact)

PROJECT_TERMS: 2 year old;Acquired Immunodeficiency Syndrome;Adopted;Age;Alleles;Animal Model;Animals;Automation;Biodiversity;Breeding;Child;Communities;Custom;Data;Data Analyses;Data Set;design;Ensure;exome sequencing;Flow Cytometry;Genes;Genetic;Genetic Variation;genomic data;Genotype;germ free condition;Health;HIV Infections;Housing;Human;Immunophenotyping;Infant;Informatics;interest;Label;Length;Liquid substance;Maintenance;male;Methods;MHC Class I Genes;Microchimerism;Modeling;Molecular;online resource;Parents;preservation;Prevention strategy;Preventive treatment;Primates;Production;public health relevance;Quality of life;Recommendation;Recording of previous events;Research;Research Personnel;Robot;Sampling;Site;Specific qualifier value;targeted exome sequencing;Time;tool;Update;Veterinarians;Women's Group;Work

PROJECT_TITLE: MHC Genetic Typing Core-Maintenance of the SPF Breeding Colonies at Yerkes National Primate Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-J]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative: Per PAR-20-043, Project Narrative is not completed.

PI_NAMEs: SHERMAN, NICHOLAS EUGENE (contact)

PROJECT_TERMS: acronyms;Advisory Committees;analytical method;anti-cancer research;Area;ATAC-seq;Binding;biobank;Bioinformatics;Biological Markers;Budgets;Cancer Center Support Grant;Cell Nucleus;Cell Separation;Cells;Clinical;Computers and Advanced Instrumentation;Consultations;cost effective;Data Analyses;data analysis pipeline;Data Collection;design;digital;DNA;driving force;Ensure;Environment;Evaluation;experience;Experimental Designs;experimental study;Flow Cytometry;Fostering;Funding;Gene Expression;Generations;genome sciences;Genomics;Genotype;Grant;Human Resources;Immunologics;instrument;instrumentation;Investigation;Kinetics;Knowledge;lipidomics;Lipids;Malignant Neoplasms;Manuscripts;mass spectrometer;Measurement;medical schools;member;metabolomics;Methods;microbiome;Microscopy;Molecular;multiple data types;multiple omics;new technology;next generation sequencing;Paper;Pharmaceutical Preparations;Phase;Post-Translational Protein Processing;Preparation;Price;protein complex;Proteomics;Publications;Research;research facility;Research Personnel;Resolution;Resource Sharing;Resources;Running;Sampling;Services;Techniques;Technology;Tissues;tool;transcriptome sequencing;transcriptomics;Translational Research;Universities;University of Virginia Cancer Center;Work

PROJECT_TITLE: BAF - SR Component

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, affecting 6.2 million individuals and families in the United States emotionally and financially, with patients suffering from devastating non-cognitive, prodromal symptoms such as anxiety, depression, agitation, and sleep disturbances early in the disease followed by cognitive impairment. With an aging population and the dearth of disease-modifying therapies available, it is imperative to investigate the mechanisms that contribute to early AD. This proposal will test the hypothesis that tau-mediated disruptions in the locus coeruleus-norepinephrine (LC-NE) system underlie the development of prodromal symptoms and uncover molecular alterations associated with LC-NE dysfunctions to develop effective therapeutic targets for AD.

PI_NAMEs: KORUKONDA, ANURADHA  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Ablation;Adrenergic Receptor;Affect;Affinity Chromatography;aging population;Agitation;Alzheimer's Disease;Alzheimer's disease patient;American;Animal Model;Anxiety;anxiety-like behavior;Arousal;astrogliosis;Attention;Axonal Transport;Behavior;Behavior assessment;Behavioral;behavioral phenotyping;beta amyloid pathology;Brain;Brain Stem;Caregivers;Cell Nucleus;cell type;Cells;Clinical Trials Design;Cognitive;Cognitive deficits;common symptom;Coupled;Dementia;Deposition;Development;diagnostic tool;Disease;Disease Progression;DSP 4;Early Diagnosis;Emotional;Exhibits;experience;extracellular;Family;family burden;Foundations;Frontotemporal Dementia;Functional disorder;Gene Expression;Genes;Genetic;Gliosis;Goals;Healthcare Systems;Human;Hyperactivity;hyperphosphorylated tau;Immunohistochemistry;Impaired cognition;In Situ Hybridization;Individual;Learning;locus ceruleus structure;Mediating;Memory;memory consolidation;Memory impairment;Mental Depression;Modeling;Molecular;Molecular Profiling;mouse model;Mus;mutant;Nerve Degeneration;nerve supply;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;Neurons;neuropathology;neuropsychiatric symptom;neuropsychiatry;Neurotoxins;noradrenergic;Norepinephrine;norepinephrine system;Oxidative Stress;Pathogenesis;Pathologic;Pathology;Patients;Pattern;Phase;Phenotype;Physiological Processes;postsynaptic;preventive intervention;prodromal Alzheimer's disease;promoter;Prosencephalon;Quality of life;receptor density;response;Ribosomes;Senile Plaques;Signal Transduction;Sleep;Sleep disturbances;Sleep Wake Cycle;socioeconomics;Specificity;Stress;Suggestion;Symptoms;Synaptic plasticity;targeted treatment;tau aggregation;tau mutation;tau Proteins;Techniques;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;therapeutically effective;Time;Transcript;transcriptome;transcriptomics;Transgenes;Transgenic Mice;Translating;translating ribosome affinity purification and RNA-sequencing;transmission process;United States;Viral Vector;Work

PROJECT_TITLE: Behavioral and Molecular Consequences of Tau Pathology in Locus Coeruleus in Prodromal Alzheimer's Disease


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Rehabilitation

ORG_CITY: CAMBRIDGE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: 8. PROJECT NARRATIVE Children and adolescents who receive outpatient mental health care have multiple problems and disorders, and their most pressing problems often shift during treatment. These challenges are addressed by a flexible new treatment program called FIRST, developed in collaboration with mental health clinicians and guided by five empirically supported principles of change (e.g., calming, problem solving), each applicable to treatment of depression, anxiety/OCD, trauma, and misconduct. The proposed study will provide the first randomized controlled effectiveness trial of this new practice-adapted transdiagnostic treatment, plus an inquiry into the process through which it may work and therapist factors that may strengthen or weaken its implementation.

PI_NAMEs: BEARMAN, SARAH KATE KATE;WEISZ, JOHN RICHARD (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: Address;Adherence;Adolescent;Affect;Aftercare;aged;Ambulatory Care Facilities;Anxiety;Area;Attitude;Behavioral;Benchmarking;Boston;Caregivers;Characteristics;Child;Clinic;Clinical;clinical practice;Code;cognitive reappraisal;Collaborations;Communities;community clinic;community collaboration;community setting;comorbidity;Competence;conduct problem;Consultations;cost;design;Diagnosis;Diagnostic;Disease;distress tolerance;DSM-V;effectiveness trial;effectiveness/implementation design;Emotional;Emotions;Ethnic Origin;Evidence based practice;Family;flexibility;Frustration;functional outcomes;Growth;implementation cost;improved;Incentives;Individual;informant;Intervention;Investigation;Investigational Therapies;Knowledge;Learning;Measures;Mediating;Mental Depression;Mental Health;Mental Health Services;Methods;metropolitan;Modeling;Motivation;National Institute of Mental Health;negative affect;next generation;Outcome;Outpatients;Parents;Participant;Pattern;Performance;personalized medicine;post-traumatic stress;practice setting;Problem Solving;Process;Protocols documentation;provider factors;Psychopathology;Psychotherapy;Randomized;randomized trial;Regulation;Relaxation;Reporting;Role;Sampling;Scientist;Severities;standardize measure;Techniques;Testing;Theoretical model;Therapeutic;Training;Trauma;treatment as usual;treatment program;uptake;Work;Youth

PROJECT_TITLE: Testing FIRST in Youth Outpatient Psychotherapy


NIH_SPENDING_CATS: Cancer

PI_NAMEs: ZHU, HONG  (contact)

PROJECT_TERMS: acronyms;Address;anti-cancer research;Basic Science;Biological Markers;Biometry;Biostatistics Shared Resource;Cancer Center Support Grant;Clinical;clinical trial analysis;Clinical Trials Design;Collaborations;computer program;Conformal Radiotherapy;Consultations;Data;design;Development;Diagnostic;Dose;early phase clinical trial;Education;Ensure;Event;experience;Focal Adhesion Kinase 1;Goals;Health Sciences;Infrastructure;Laboratory Scientists;Laboratory Study;lectures;Life;Linear Models;Measures;medical schools;meetings;member;Methodology;Methods;Mission;Monitor;Monitoring Clinical Trials;Non-linear Models;novel;Observational Study;Outcome;Outcomes Research;Phase;Population;Population Sciences;Population Study;preclinical study;predictive modeling;programs;Protocols documentation;Public Health;Quality Control;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Review Committee;Safety;Science;skills;Statistical Methods;Time;Translational Research;University of Virginia Cancer Center

PROJECT_TITLE: BSR - SR Component


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: RUMPEL, CRAIG ANDREW (contact)

PROJECT_TERMS: acronyms;Advisory Committees;American Association of Cancer Research;Anatomy;Animal Cancer Model;anti-cancer research;automated image analysis;Basic Science;biobank;Biological;Blood;Blood specimen;Board Certification;cancer biomarkers;Cancer Center Support Grant;cancer therapy;Clinical;Clinical Research;Clinical Trials;Color;Complex;digital;digital imaging;Disease;Flow Cytometry;Histological Techniques;Histology;Histopathology;Human;human tissue;Image Analysis;Immunohistochemistry;Immunologics;In Situ Hybridization;Informatics;insight;International;Laboratories;laser capture microdissection;Lasers;Malignant Neoplasms;manufacture;medical schools;Microarray Analysis;Microdissection;Molecular Analysis;Neoplasm Circulating Cells;next generation sequencing;Nucleic Acids;Oncology;Operative Surgical Procedures;Pathologist;Pathology;Procedures;Process;programs;repository;Research;research facility;Research Personnel;Research Support;Resource Informatics;Resource Sharing;RNA;Scanning;Services;Slide;Societies;Specimen;Techniques;Therapeutic;Therapy Clinical Trials;Tissue Extracts;Tissue Microarray;Tissue Sample;Tissues;Translational Research;Universities;University of Virginia Cancer Center;Urine;Validation;Virginia

PROJECT_TITLE: BTRF - SR Compnent


NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: SOLGA, MICHAEL D. (contact)

PROJECT_TERMS: acronyms;Address;advanced analytics;Advisory Committees;anti-cancer research;Apoptosis;Applications Grants;biobank;Bioinformatics;Cancer Center Support Grant;cancer type;career;Cell Separation;Cell Survival;Certification;Collaborations;Compensation;Complex;Consultations;cost;cost effective;Data;Data Analyses;design;Detection;detector;Diagnostic;DNA;E-learning;Education;Electronics;Ensure;experience;Experimental Designs;experimental study;extracellular vesicles;Flow Cytometry;Fluorochrome;Genetic Transcription;Head;high dimensionality;Human Resources;Image;Immune response;Immunoassay;Immunologics;instrument;instrumentation;interest;Learning;Licensing;Literature;Malignant Neoplasms;Measurement;member;Membrane Potentials;Methods;Molecular;Monitor;multidimensional data;novel;Optics;Outcome;Performance;Play;Preparation;programs;Publications;Publishing;Qualifying;quality assurance;Reproducibility;research facility;Research Personnel;Resolution;Resource Sharing;Resources;RNA;Sampling;Scientist;Series;Services;single cell analysis;Site;Sorting;Stains;student participation;Techniques;Technology;theories;Tissues;tool;Training;Training and Education;Translational Research;University of Virginia Cancer Center

PROJECT_TITLE: FCF - SR Component


ADMINISTERING_IC: DK

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative In this proposal, we test the hypothesis that biochemical pathways of relevance in the biology of aging can be coopted to treat and prevent obesity and its complications. We focus on the activation of fat mobilization and utilization by a process called mitohormesis, which is thought to promote longevity through alterations in nutrient metabolism and energy balance. Our results will provide new insights into and a new paradigm to approach the pathogenesis of obesity and its treatment.

PI_NAMEs: BITTO, ALESSANDRO  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: adefovir dipivoxil;Adipocytes;Adipose tissue;Adult;Aging;analytical tool;Animals;Antioxidants;Architecture;Attenuated;Big Data;Biochemical Pathway;biological adaptation to stress;Biological Aging;Biology;Biology of Aging;blood glucose regulation;Body Weight decreased;Caloric Restriction;Cardiovascular Diseases;Catabolism;CCAAT-Enhancer-Binding Proteins;Chronic Disease;constitutive expression;Data;Data Analyses;Developed Countries;Diabetes Mellitus;Diet;diet-induced obesity;DNA polymerase gamma;Endocrine;energy balance;Energy Metabolism;experimental study;factor C;Fatty acid glycerol esters;fatty acid metabolism;fatty acid oxidation;FDA approved;FRAP1 gene;Gene Expression;Genes;Genetic;Geroscience;glucose metabolism;Glucose tolerance test;Health;Hepatic;Homeostasis;Hyperglycemia;In Vitro;in vivo;Indirect Calorimetry;insight;Institution;Insulin Resistance;Intervention;Knock-in;Knock-out;lipid biosynthesis;lipid metabolism;Liver;liver metabolism;Longevity;Malignant Neoplasms;MAP Kinase Gene;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Metabolic syndrome;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Modeling;Morbid Obesity;mouse model;Mus;Neurologic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;nucleoside analog;Nutrient;nutrient metabolism;Obese Mice;obese person;Obesity;obesity prevention;obesity treatment;obesogenic;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathology;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Population;prevent;Process;programs;Property;protein expression;Protein Isoforms;Proteins;Reactive Oxygen Species;Research;response;Reverse Transcriptase Inhibitors;Risk;Risk Factors;Rodent;Role;side effect;Stress;stress activated protein kinase;stressor;Techniques;Testing;tissue culture;Tissues;Training;transcription factor;Transgenic Model;Translations;United States;Viral;Weight

PROJECT_TITLE: Activation of C/EBP-β by mitohormesis as a therapy for obesity

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer

PI_NAMEs: BERR, STUART S. (contact)

PROJECT_TERMS: Address;Advisory Committees;Alleles;Animal Cancer Model;Animal Disease Models;animal imaging;Animal Model;Animals;biobank;Biological Assay;Biometry;Blood specimen;Cancer Center Support Grant;Cancer Model;cancer therapy;Clinical;Clinical Research;Clinical Trials;comparative;conditional knockout;cost;cost effective;CRISPR/Cas technology;Dedications;Derivation procedure;design;Development;Diagnosis;dimensional analysis;disease model;drug development;enzyme linked immunospot assay;Equipment;experimental study;Flow Cytometry;Fluorescence;Gene Targeting;genetic technology;Genetically Engineered Mouse;Genome engineering;Goals;high dimensionality;Hour;Human;human disease;human imaging;human tissue;Image;Imaging technology;Immunocompetent;Immunohistochemistry;Immunologic Markers;Immunologic Monitoring;Immunologics;implantation;in vivo;in vivo imaging;innovation;instrumentation;Interdisciplinary Study;Investigation;Knock-in;Knowledge;Leadership;luminescence;Magnetic Resonance Imaging;Malignant Neoplasms;medical schools;member;Microscopy;Minor;Modality;Modeling;Molecular;molecular marker;Monitoring Clinical Trials;mouse model;Mouse Strains;Mus;patient derived xenograft model;Patients;Positron-Emission Tomography;pre-clinical;pre-clinical research;preclinical study;preservation;Price;Published Comment;radiochemical;Reproductive Technology;Research;research facility;Research Personnel;Research Project Grants;Resource Sharing;Resources;Rodent;Rodent Model;Running;Sampling;Services;single photon emission computed tomography;skills;Systems Development;Techniques;Technology;Therapeutic;Time;Tissues;Training;Translational Research;Translations;tumor;tumor xenograft;University of Virginia Cancer Center;X-Ray Computed Tomography

PROJECT_TITLE: MITS - SR Component


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Health Services;Physical Rehabilitation;Rehabilitation

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA RESEARCH FOUNDATION, INC.

ORG_STATE: OR

PHR: Project Narrative This is a renewal proposal requesting an additional five years of funding to support a three-month T35 summer training program at the Department of Veterans Affairs National Center for Rehabilitative Auditory Research (NCRAR) for students enrolled in a Doctor of Audiology (Au.D.) clinical degree program. The purpose of the training is to encourage an interest in hearing research and research careers using an intensive short-term immersion in an auditory research environment combined with an individual mentored research project.

PI_NAMEs: KONRAD-MARTIN, DAWN L (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Accreditation;Advisory Committees;American;Audiology;Auditory;career;career development;Clinical;Data;Degree program;Department chair;design;Diagnosis;Doctor of Philosophy;Educational Curriculum;Eligibility Determination;Enrollment;equilibration disorder;Evaluation;Faculty;Funding;Goals;Grant;health care service;Hearing;Hearing problem;Human;Individual;Institution;interest;Journals;Laboratories;Letters;meetings;member;Mentors;Methodology;National Research Service Awards;Peer Review;Prevention;professor;Program Sustainability;programs;Publications;Publishing;Recommendation;Rehabilitation Centers;Rehabilitation therapy;Request for Proposals;Research;research facility;research faculty;Research Personnel;Research Project Grants;Research Training;Societies;student participation;Students;symposium;Traineeship;Training Programs;undergraduate student;United States National Institutes of Health;Visit;web site;Work

PROJECT_TITLE: Ruth L. Kirschstein NRSA Short-Term Institutional Research Training Grant (T35)


NIH_SPENDING_CATS: Aging;Genetics;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: The rate of bone repair slows with aging resulting in substantial morbidity and even mortality. This proposal will use heterochronic parabiosis (two mice of a different age share a blood supply) to identify the specific macrophage cell subpopulations and the proteins they secrete that are responsible for the rejuvenation. Our results will inform the development of new therapies to improve fracture healing in older individuals.

PI_NAMEs: ALMAN, BENJAMIN AARON (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Address;Age;aged;Aging;Alleles;animal old age;Automobile Driving;beta catenin;bone;bone fracture repair;bone healing;Bone Marrow Cells;Bone Marrow Transplantation;bone repair;cathelicidin antimicrobial peptide;Cell Death;Cell Differentiation process;Cell Lineage;Cell Proliferation;Cell secretion;Cells;Characteristics;Circulation;Clinical;Cyclic AMP Receptors;Data;defined contribution;Development;differentiation in vitro;Erythro;experimental study;Exposure to;fetal;gene function;Gene Modified;Genes;healing;improved;In Vitro;in vivo;juvenile animal;Knowledge;Label;LDL-Receptor Related Protein 1;Macrophage;mature animal;mechanical properties;Mediating;Mesenchymal;Mesenchymal Differentiation;Morbidity - disease rate;mortality;Mus;Myeloid Progenitor Cells;novel therapeutic intervention;novel therapeutics;old mice;older adult;older patient;Older Population;Operative Surgical Procedures;osteoblast differentiation;Osteoblasts;Parabiosis;Phenotype;Population;progenitor;Protein Secretion;Proteins;Recombinants;recruit;Rejuvenation;repaired;resistin;response;Role;single-cell RNA sequencing;Source;Spleen;Splenectomy;Testing;Undifferentiated;Vascular blood supply;Work;Yolk Sac

PROJECT_TITLE: The role of macrophage subpopulations in the rejuvenation of fracture repair


NIH_SPENDING_CATS: Cancer;Prevention

PI_NAMEs: YOU, WEN  (contact)

PROJECT_TERMS: Address;anti-cancer research;Applications Grants;Basic Science;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Control;cancer risk;Catchment Area;Centers for Population Health;Clinical Sciences;Data;Data Analyses;Data Collection;design;Development;Evaluation;Fee-for-Service Plans;Goals;health assessment;Hour;improved;instrument;Malignant Neoplasms;Measures;member;Methods;Mission;Outcome;Pattern;Pilot Projects;Policies;Population;Population Analysis;population based;population health;Population Research;Population Study;Population trends;programs;Publications;Quality of life;Research Design;Research Personnel;Resource Sharing;Resources;Services;Statistical Data Interpretation;survivorship;trend;University of Virginia Cancer Center;Work

PROJECT_TITLE: PHCOC - SR Component


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative: The role of obscurin and Obsl1 as key determinants for diastolic function This project investigates molecular determinants for the development of heart failure with preserved ejection fraction (HFpEF), a disease that accounts for approximately 50% of heart failure hospital admissions in the US. Mice that lack obscurin/Obsl1 die prematurely and develop diastolic dysfunction, a key pathogenic feature of HFpEF. Using this novel genetic model of diastolic dysfunction, we aim to uncover novel mechanistic roles of obscurin/Obsl1 for mitochondrial function, their inﬂuence on the cardiac metabolism, and on sarcoplasmic reticulum proteins that determine cardiac calcium cycling.

PI_NAMEs: CHO, YOSHITAKE  (contact);LANGE, STEPHAN

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Accounting;Adult;Affect;Age;Animal Model;Arrhythmia;Binding;Biogenesis;Biological Process;Biopsy;Calcium;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular Physiology;Cessation of life;Clinical;comorbidity;connectin;coronary fibrosis;Data;Development;Diabetes Mellitus;Diagnosis;Diastole;Disease;disease model;Disease susceptibility;Doppler Echocardiography;EFRAC;Epidemiology;Etiology;Experimental Models;experimental study;Fatty Acids;Functional disorder;Gender;Genetic Diseases;Genetic Models;Glucose;Goals;health economics;Heart;Heart failure;heart failure with reduced ejection fraction;heart metabolism;hemodynamics;High Prevalence;Hospitalization;Hypertension;Impairment;interest;Knock-out;Knockout Mice;life span;Measures;Mediating;Metabolic;Metabolism;metabolomics;Mitochondria;mitochondrial metabolism;Mitochondrial Proteins;Modeling;Molecular;Molecular Target;mortality;Mus;Nitric Oxide;novel;novel therapeutics;Obesity;obscurin;Onset of illness;Outcome;overexpression;Pathogenicity;Pathway interactions;patient population;Patients;Phosphorylation;Physiologic pulse;Physiological;Physiology;Play;pre-clinical;Pre-Clinical Model;premature;preservation;pressure;Process;protein function;Protein Overexpression;Proteins;Proteome;Publishing;Relaxation;Reporting;Resolution;Respiratory physiology;reuptake;Risk Factors;RNA Splicing;Role;Sarcoplasmic Reticulum;sex;Sex Differences;Signal Transduction;socioeconomics;spatiotemporal;Specific qualifier value;Structure;Syndrome;Telemetry;Testing;therapy development;Tissues;Transgenic Mice;women patients;Work

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Kidney Disease;Pediatric;Urologic Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE / RELEVANCE TO PUBLIC HEALTH Hydronephrosis diagnosed in utero but persisting after birth (PNH) affects tens of thousands of infants each year in the United States, but its management is complicated by ambiguous reporting of hydronephrosis severity and a relatively limited understanding of predictors of disease outcome and knowledge of the disease’s natural history. The proposed research uses the largest known pediatric hydronephrosis cohort to develop a tool to translates free-text ultrasound reports into coded PNH grades, predict the 2-year outcome using 3-month baseline data, and apply sophisticated modeling techniques to simulate the disease’s natural history. Taken together, results from this proposal will lead to the development of a standardized management strategy for PNH and facilitate the candidate’s transition to an independent research career in the development, dissemination, and implementation of novel treatment and management strategies for pediatric urologic disease, beginning with pediatric hydronephrosis.

PI_NAMEs: SCHAEFFER, ANTHONY J (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 2 year old;Address;Affect;Age;Algorithms;antenatal;Anterior;Bioinformatics;Biometry;Birth;career;career development;Characteristics;Child;Child Care;Childhood;Chronic Disease;Classification;Clinical;clinical care;clinical decision support;Clinical Decision Support Systems;clinical decision-making;clinical practice;Code;cohort;Computerized Medical Record;Data;data warehouse;design;Development;Development Plans;Diagnostic;Diagnostic tests;Diameter;Disease;disease classification;disease natural history;Disease Outcome;dissemination science;Doctor of Philosophy;Early identification;Ensure;Epidemiology;Etiology;evidence base;experience;Face;follow-up;Foundations;Frequencies;Goals;Growth;Healthcare;Hospitals;Hydronephrosis;implementation science;improved;in utero diagnosis;Infant;International;Intervention;K-Series Research Career Programs;Kidney;Kidney Failure;Kidney Transplantation;Knowledge;Life;Manuals;Mentors;Mentorship;Modeling;Monitor;multidisciplinary;Natural History;Natural Language Processing;novel;Obstruction;Operative Surgical Procedures;Outcome;outcome prediction;Outpatients;Patient Care;Patients;Pediatric Hospitals;Pediatric Radiology;pediatrician;Performance;postnatal;Predictive Factor;Pregnancy;prenatal;prognostication;Provider;Public Health;Radiology Specialty;Randomized, Controlled Trials;Renal function;Renal pelvis;Reporting;Research;research and development;Research Personnel;Resolution;Risk;Risk Factors;Sampling;Scanning;Scientist;Selection Bias;Severities;skills;Solid;Source;Specialist;Standardization;structured data;support tools;System;Techniques;tertiary care;Testing;Text;Time;tool;Training;Translating;Ultrasonography;ultrasound;United States;urinary;urologic;Urologic Diseases;Urologic Surgeon;Urology;Utah;Validation;Work

PROJECT_TITLE: The Utah-Cohort Of Postnatally persistent Antenatal Hydronephrosis (U-COPAH)

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Diabetes;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Individuals with type 2 diabetes have 50-100% higher risk of dementia than elderly individuals without type 2 diabetes yet much remains to be learned regarding how to best mitigate this risk. The proposed research aims to understand how specific characteristics of long-term glycemic control (e.g. level, variance, cumulative exposure, trajectories) and classes of diabetes therapies impact risk of dementia while taking into consideration important contextual factors, such as diabetes complications, in a large population of elderly patients with type 2 diabetes. The results of this project will have direct clinical translation for glycemic targets and will inform approaches to prevention of cognitive impairment in this population which is already at elevated dementia risk.

PI_NAMEs: GILSANZ, PAOLA  (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Acute;Address;Adult;Affect;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Attenuated;Blood Vessels;California;causal model;Characteristics;clinical care;clinical practice;clinical translation;cognitive benefits;cognitive function;cohort;comorbidity;Complications of Diabetes Mellitus;contextual factors;cost effective;Data;Dementia;dementia risk;Development;Diabetes Mellitus;diabetes mellitus therapy;Elderly;Epidemic;Etiology;Event;Exposure to;Future;glycemic control;Glycosylated hemoglobin A;Goals;Guidelines;high risk;human old age (65+);Hyperglycemia;Hypoglycemia;Hypoglycemic Agents;Impaired cognition;improved;Individual;innovation;insight;Insulin;Integrated Delivery of Health Care;Intervention;Knowledge;late life;Learning;Link;longitudinal analysis;Longitudinal Studies;macrovascular disease;Measures;Medical Records;member;Metabolic;Metformin;Microvascular Dysfunction;Modeling;modifiable risk;mortality;Non-Insulin-Dependent Diabetes Mellitus;older patient;Patients;Pattern;Persons;Pharmacotherapy;Population;Populations at Risk;Prevalence;Prevention approach;protective factors;Public Health;Registries;Research;Risk;Risk Factors;risk mitigation;Risk Reduction;Role;Sample Size;Severities;Statistical Methods;Subgroup;Sulfonylurea Compounds;System;Techniques;Therapeutic;Thiazolidinediones;Time;Variant;Vulnerable Populations

PROJECT_TITLE: Glycemic Control and Dementia: The Role of Pharmacotherapy and Vascular Complications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(55)]


NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

ORG_STATE: NY

PHR: NARRATIVE Epigenetic clocks are widely used in geroscience but little known about their modifiability and behavior across the lifespan. Here we use a human cellular lifespan system that recapitulates key hallmarks of human aging (DNA methylation signatures, ccf-mtDNA, inflammation) to map individualized trajectories in the rate of epigenetic aging among cells from healthy women and men, in response to glucocorticoid stress, and to targeted mitochondrial dysfunction. These high-resolution longitudinal multi-system data will provide new insights into inter-individual differences in aging trajectories, the modifiability of epigenetic clocks, and provide causal evidence for the of mitochondrial dysfunction as a potential biological determinant of epigenetic aging.

PI_NAMEs: PICARD, MARTIN  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;Acute;Address;Age;age acceleration;age related;age-related disease;aged;Aging;aging biomarker;aging process;Algorithms;Animal Model;Behavior;biobank;Biological;Biological Aging;Biological Markers;Biology;Biometry;Blood;causal model;CDKN2A gene;Cell Aging;Cell division;Cell model;Cells;Chronic;Chronology;cohort;Coupled;Cultured Cells;cytokine;Data;Data Analyses;data modeling;Defect;demethylation;DNA;DNA analysis;DNA Methylation;DNA Sequence Alteration;Elderly;Electron Transport;epigenetic aging;epigenetic clock;Epigenetic Process;Etiology;Exhibits;experimental study;Female;Fibroblasts;Foundations;Gene Expression;Genes;Genetic;genetic approach;Genome;genomic locus;Geroscience;Glucocorticoids;Goals;Grant;hallmarks of aging;high dimensionality;Human;Human body;human DNA;human tissue;IL6 gene;In Vitro;in vivo;Individual;Individual Differences;Inflammation;Inflammatory;insight;Intervention;Length;Life;life span;Link;Longitudinal Studies;male;Maps;Measures;Mediator;men;Metabolic;Metabolic dysfunction;Methods;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial genome;Modeling;Modification;Molecular Profiling;Monitor;mortality;Mutation;Nature;novel;Oxygen;Patients;Pattern;personalized predictions;Persons;pharmacologic;Physiological;pre-clinical;prediction algorithm;Psychosocial Stress;Publications;rare variant;rate of aging;Regulation;Reproducibility;Research;Resolution;Resources;respiratory;response;Role;Sex Differences;Signal Transduction;Skin;Stress;stressor;System;telomere;temporal measurement;Testing;Ticks;Time;Twin Multiple Birth;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Metabolic regulation of human DNA methylation clocks

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Coronaviruses;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: The proposed studies will help delineate the biological processes occurring in the lungs of pneumonia patients, with cases anticipated to cluster into different types of lung responses. The sub-types of pneumonia will be investigated using innovative experimental systems and defined at both microscopic and molecular levels within the lung. Differentiating pneumonia sub-types will mean that current and emerging treatments can be delivered more precisely, to target those most likely to benefit and spare those who may be harmed instead.

PI_NAMEs: MIZGERD, JOSEPH P (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Address;adverse outcome;Alveolar;Autopsy;Biological;Biological Process;Biology;Blood specimen;Board Certification;cell type;Cells;Cessation of life;Characteristics;cohort;Communities;COVID-19;Data Set;Development;Disease;disease phenotype;Elderly;Elements;empowerment;Etiology;Experimental Models;feature selection;Floods;Functional disorder;Future;Gene Expression;Goals;Growth;Heterogeneity;high risk population;Histopathology;Hospitalization;Human;Immune;Immune response;Immunity;Immunohistochemistry;Immunologics;improved;in vivo;Infection;Inflammation;Influenza;Injury;innovation;insight;Intensive Care;Knowledge;Lung;Lung infections;Measures;microbial;Microscopic;Microscopy;Modeling;Molecular;mouse model;Pathologist;Pathology;Pathway interactions;Patients;Pattern;Phenotype;Pneumonia;precision medicine;prevent;Prospective cohort;Proteins;Pulmonary Pathology;Research Priority;Resolution;response;Sampling;segregation;single nucleus RNA-sequencing;Site;Slide;Streptococcus pneumoniae;Structure of parenchyma of lung;System;Testing;Tissue Sample;Tissues;tool;Transcript;transcriptomics;United States National Institutes of Health

PROJECT_TITLE: Pulmonary pathophysiology sub-phenotypes of pneumonia

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Natural Products

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE This program aims to develop basic science, methods, and technologies that substantially improve drug discovery from natural sources and that enable synthetic biology-based development of pharmaceuticals. Ultimately, the resulting technologies will find use in wide ranging applications, from synthesis of pharmaceuticals to cell-based therapies.

PI_NAMEs: SCHMIDT, ERIC W (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Address;Anabolism;Animals;applied biomedical research;Area;Bacteria;Basic Science;bioactive natural products;Biochemical;Biochemical Pathway;Biological;Cell Therapy;Cells;Chemicals;competitive environment;design;Development;drug development;drug discovery;enzyme pathway;Family;FDA approved;Funding;Gene Library;Generations;improved;Individual;innovation;Laboratories;Lead;Learning;Life;marine;marine natural product;Methods;Natural Products;Natural Source;Nature;novel;Oceans;Organism;Parents;Pathway interactions;Pharmacologic Substance;Planet Earth;programs;Research;scaffold;Sea;Side;small molecule;Structure;symbiont;Symbiosis;synergism;synthetic biology;Technology;Testing;Therapeutic;tool;Touch sensation;Variant

PROJECT_TITLE: Symbiosis and Chemical Diversity Generation

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This U24 network on emotional well-being (EWB) will catalyze the emerging field of the plasticity of well-being and will showcase how well-being can be learned and the consequences of such skill development on physical and emotional health and on prevention of disease. A framework for understanding how well-being can be learned along with measures of the core components of well-being that can be learned will be developed and disseminated. The network will also train new investigators in this area and will engage established investigators to contribute to this field.

PI_NAMEs: DAVIDSON, RICHARD J (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Acceleration;Area;Attention;Awareness;Behavior;Behavioral;Biological;Cellular Phone;Communities;computer science;Computers;Consensus;cost;Data;Data Collection;Data Set;Development;digital technology;disorder prevention;Distal;Drug abuse;Elements;Emotional;Engineering;Face;Friends;Future;Grant;Health;Human;Humanities;indexing;Individual Differences;Institution;Interruption;Learning;learning strategy;Literature;machine learning algorithm;Measurement;Measures;meetings;member;Mental Depression;Methodology;mHealth;Mind;mindfulness meditation;Modernization;multidisciplinary;Neurosciences;novel;Outcome;Patient Self-Report;Personal Satisfaction;physical conditioning;Pilot Projects;Plague;Population Biology;population health;Populations at Risk;prevent;Prevention strategy;Program Evaluation;programs;psychologic;Psychology;Publications;Questionnaires;Randomized, Controlled Trials;Regulation;Reporting;Research;Research Personnel;Research Priority;response;Sampling;Scientist;Signal Transduction;skill acquisition;social;Specific qualifier value;standard measure;Subgroup;Techniques;technology development;tool;Training;virtual;web site;Well in self;Work;Writing

PROJECT_TITLE: The plasticity of well-being:  A research network to define, measure and promote human flourishing


PHR: Public health relevance statement: Methods developed in this proposal can be applied to the preparation of bioactive compounds, which will facilitate our understanding for human diseases and the development of therapeutics.

PI_NAMEs: TANG, WEIPING  (contact)

PROJECT_TERMS: Acylation;Address;Alkylation;Binding;Biological;Biological Process;Carbohydrates;catalyst;Cell surface;cell type;chemical synthesis;Chemicals;Chimera organism;Development;Disease;extracellular;Extracellular Protein;Glycoconjugates;Glycoproteins;Glycosides;glycosylation;Goals;human disease;hydroxyl group;Hydroxyl Radical;improved;Instruction;Ligands;Lysosomes;Methods;novel;Play;Polysaccharides;Preparation;Process;programs;protein degradation;Proteins;public health relevance;receptor;receptor mediated endocytosis;Reporting;Research;Role;Series;Site;Sulfate;therapeutic development;Transition Elements

PROJECT_TITLE: Chemical Synthesis and Biological Application of Carbohydrates and Glycoconjugates


ADMINISTERING_IC: HG

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Public Health Relevancy Statement Gene expression is tightly controlled in time and space and is governed by protein-nucleic acid (DNA and RNA) interactions. There are hundreds of DNA- and RNA-binding proteins that regulate gene expression and many are mutated in disease, but we lack facile approaches to map these proteins to their DNA/RNA targets. Here we propose to develop an innovative set of tools that will give every molecular biology lab the possibility to obtain comprehensive cell-type specific protein DNA/RNA interaction maps, a necessity to understand gene expression regulation and therefore disease development.

PI_NAMEs: GUTTMAN, MITCHELL ;JOVANOVIC, MARKO  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Address;Amyotrophic Lateral Sclerosis;Antibodies;Bar Codes;Benchmarking;Binding;Binding Proteins;Binding Sites;Biological;Biological Assay;Cell Line;cell type;Cells;Chromatin;chromatin immunoprecipitation;chromatin modification;combinatorial;Communities;Complex;Consumption;cost;crosslink;Data;Data Set;Development;Disease;disease model;DNA;DNA Binding;DNA mapping;DNA-Binding Proteins;DNA-Protein Interaction;empowerment;Ensure;epigenomics;experimental study;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Transcription;genome-wide;genomic data;Genomic DNA;genomic RNA;Genomics;Goals;High-Throughput Nucleotide Sequencing;histone modification;human disease;Immunoprecipitation;Individual;innovation;innovative technologies;insight;interest;International;Link;Maps;Measurement;Messenger RNA;Methods;Molecular Biology;mRNA Transcript Degradation;Mutate;Mutation;Neurodegenerative Disorders;Neurons;novel;nucleic acid mapping;Nucleic Acids;Patients;Population;Post-Translational Protein Processing;posttranscriptional;Process;protein expression;Proteins;Protocols documentation;Public Health;recruit;Research;Research Personnel;RNA;RNA Binding;RNA Sequences;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;Sampling;Sensitivity and Specificity;Specificity;Technology;Time;tool;transcription factor;Transcriptional Regulation;transcriptome;Translations

PROJECT_TITLE: Extensive multiplexing of protein nucleic-acid interactions to comprehensively study gene expression regulation from chromatin to mRNA degradation

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_DEPT: CHEMISTRY

PHR: PROJECT NARRATIVE Nucleic acids (DNA and RNA) and their building blocks (nucleosides and nucleotides) play central roles in all cellular events and, as such, have immense impact on the emergence of diseases and, in turn, on human health. Studying such cellular events is complicated by the non-emissive nature of the natural nucleobases, which necessitates the development of new fluorescent analogs of nucleosides, nucleotides and oligonucleotides. Faithful emissive nucleoside surrogates, combined with powerful real-time fluorescence- based methods, will further the fundamental understanding of key biological processes related to disease development and will have long-term impact on improving human health by advancing diagnostic tools and facilitating drug discovery.

PI_NAMEs: TOR, YITZHAK  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Articulation;Automobile Driving;Basic Science;Biochemical;Biological Process;biophysical techniques;Circular Dichroism;cofactor;Communities;design;Development;diagnostic tool;Disease;DNA;drug discovery;Enzymatic Biochemistry;Enzymes;Event;experimental study;Family;Fluorescence;Future;Goals;Health;high throughput screening;Human;Image;improved;innovation;Laboratories;Membrane;Metabolism;Methods;Modernization;Monitor;mRNA Decay;multi-photon;Nature;Nucleic Acids;nucleobase;nucleoside analog;Nucleosides;nucleotide analog;Nucleotides;Oligonucleotides;Organelles;Peptidyltransferase;Phase;Play;Process;programs;Research Personnel;Resolution;RNA;Role;Screening procedure;Signal Transduction;single molecule;Spectrum Analysis;Structure;Techniques;Time;tv watching

PROJECT_TITLE: Fluorescent nucleosides, nucleotides and oligonucleotides

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Muscular Dystrophy;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Gene therapy approaches to treat Duchenne muscular dystrophy (DMD), a fatal neuromuscular disease, are currently being tested in patients, but will require anti-inflammatory co-therapies. This application will test the anti-inflammatory properties of FDA-approved mineralocorticoid receptor (MR) antagonists, which have been shown to have benefits for dystrophic pathologies. The efficacy of these drugs will also be compared with current anti-inflammatory treatments that have serious side effects.

PI_NAMEs: RAFAEL-FORTNEY, JILL A (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Ablation;Acute;Address;adenovirus mediated delivery;Adult;Agonist;Aldosterone;antagonist;Anti-Inflammatory Agents;Antiinflammatory Effect;Becker Muscular Dystrophy;Binding;boys;Cardiac;Cardiomyopathies;Carrying Capacities;Cells;Chronic;Clinical;Clinical Data;Clinical Trials;Code;conditional knockout;cytokine;Cytokine Receptor Gene;Data;Dependovirus;Drug Combinations;drug efficacy;Drug usage;Duchenne cardiomyopathy;Duchenne muscular dystrophy;Dystrophin;efficacy outcomes;eplerenone;Exercise;FDA approved;fiber cell;Fibrosis;Gene Expression;Gene Expression Profile;gene function;gene therapy;Gene Transfer;Genotype;Glucocorticoids;Human;Immune;immune function;Immune response;improved;Infiltration;Inflammation;Inflammatory;Injury;Lead;Length;Macrophage;mdx mouse;Measurement;Membrane;Methods;micro-dystrophin;middle age;Mineralocorticoid Receptor;miniaturize;Modeling;Molecular;mouse model;Mus;Muscle;Muscle Fibers;muscle progenitor cell;muscle regeneration;Muscle satellite cell;Muscular Atrophy;Muscular Dystrophies;muscular dystrophy mouse model;Myelogenous;Myeloid Cells;neuromuscular;Neuromuscular Diseases;novel;Outcome;Pathogenesis;Pathology;Patients;Population;preclinical efficacy;prednisolone;Prednisone;prevent;Prevention;Property;Proteins;Publishing;receptor;Receptor Activation;Receptor Inhibition;Receptor Signaling;repaired;side effect;Skeletal Muscle;Sorting;Spinal Fractures;Spironolactone;standard of care;System;Testing;Transfection;transgene expression;Transgenes;Translating

PROJECT_TITLE: Mechanisms of mineralocorticoid receptor antagonism on inflammation in muscular dystrophy

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Prevention

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: PROJECT NARRATIVE How decisions related to emotional behaviors are generated in the brain is not well understood. Here, we investigate the molecular and neural mechanisms of fear- and anxiety-related behaviors elicited by sensory signals, using innate defensive behaviors towards predators as a model. This study will critically contribute to our understanding of pre-programmed brain machinery that controls emotion-related behaviors.

PI_NAMEs: HAGA-YAMANAKA, SACHIKO  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Acute;Afferent Neurons;Animals;Anxiety;anxiety-related behavior;Behavior;Behavior assessment;Behavioral;behavioral response;Brain;Brain Mapping;Chemicals;Cues;Data;Decision Making;Detection;emotional behavior;Emotions;Esthesia;Exhibits;experimental study;Felis catus;Freezing;Fright;Genetic;Impairment;Individual;insight;Knockout Mice;Literature;Mediating;Modality;Modeling;Molecular;Mus;mutant mouse model;neural;neural circuit;neuromechanism;Neurons;Neurosciences;Organ;Output;Pharmacogenetics;Population;Process;Property;Proteins;Protocols documentation;receptor;Receptor Gene;Recombinants;response;Risk Assessment;Saliva;saliva mediated;saliva sample;Sensory;Sensory Receptors;sensory stimulus;Signal Induction;Signal Transduction;Smell Perception;Stress;Stretching;Testing;tool;vigilance

PROJECT_TITLE: Molecular and neural mechanisms of predator cue sensation

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


NIH_SPENDING_CATS: Cancer;Dietary Supplements;Hearing Loss;Natural Products;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative  We found that honokiol can activate multiple members of the sirtuin deacetylase family, which are critical regulators of the intrinsic antioxidant system working in different parts of the cells such as the cytoplasm, mitochondria, and nucleus. In this proposal, we would like to verify the role of sirtuins in the protective effect of honokiol against cisplatin-unduced hearing loss. The results of the proposed study will lay the groundwork for a clinical trial, in which honokiol is used in parellel with the antitumor drugs (cisplatin) in chematherapy for hearing protection.

PI_NAMEs: TAN, XIAODONG  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Address;Adverse effects;Affect;Aftercare;Animals;anti-tumor drug;Antioxidants;antitumor effect;Apoptosis;Auditory Brainstem Responses;biological adaptation to stress;Blood;Cancer Patient;carcinogenesis;Cell Nucleus;Cell Physiology;Cells;chemotherapy;Chemotherapy-Oncologic Procedure;Cisplatin;cisplatin induced hearing loss;Clinic;Clinical;Clinical Treatment;Clinical Trials;clinically significant;Cochlea;Compensation;confocal imaging;cytokine;Cytoplasm;Data;Deacetylase;Dose;Drug Metabolic Detoxication;Drug Screening;Drug Targeting;Drug usage;early onset;Elements;Enzymes;Experimental Designs;experimental study;Family;FDA approved;Fluorescence Microscopy;Free Radical Scavengers;Generations;Hearing;hearing impairment;Hearing Protection;Hearing Tests;honokiol;Human;improved;Inflammation;inhibitor;insight;Isocitrate Dehydrogenase;Knock-out;Knockout Mice;Labyrinth;Location;Longevity;Mammary Neoplasms;Measurement;Measures;member;meter;microCT;Mitochondria;Modeling;Morphology;mouse model;Mus;neoplastic cell;neuron loss;Noise;Normal Cell;Organ of Corti;otoacoustic emission;ototoxicity;Outer Hair Cells;oxidative damage;Oxidative Stress;Pathway interactions;Permeability;Pharmaceutical Preparations;Phase;Pilot Projects;Platinum;polyphenol;Presbycusis;prevent;protective effect;Publications;Publishing;Reactive Oxygen Species;Recovery;Regimen;Research;Resolution;response;Roentgen Rays;Role;Signal Pathway;Sirtuins;Site;SOD2 gene;spiral ganglion;Stria Vascularis;Structure;Synapses;System;Testing;Therapeutic Effect;Toxic effect;Transgenic Organisms;tumor;Western Blotting

PROJECT_TITLE: Hearing Protection in Cisplatin Chemotherapy

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Osteoarthritis (OA) is the most common form of arthritis in the elderly and there is currently no effective treatment. In our experiments we've found that lymphatic vessels in mice with age-related OA have insufficient drainage of fluids from their joints due to decreased production of one protein (VEGF-C) and increased breakdown of another (VEGFR3). Our research suggests that a combined treatment, adding the lacking protein VEGF-C with a drug that inhibits VEGFR3 breakdown may well improve lymphatic drainage and result in a successful therapy for OA in the elderly.

PI_NAMEs: XING, LIANPING  (contact)

PROJECT_TERMS: Affect;age related;age-related disease;aged;Aging;aging related disease;Alzheimer's Disease;Arthritis;arthropathies;Attenuated;Bioinformatics;Bone remodeling;Bone Spur;Cartilage;Cell Physiology;Cells;Chronic;Clinical;Combined Modality Therapy;Data;Degenerative polyarthritis;Development;Drainage procedure;draining lymph node;effective therapy;Elderly;experimental study;Functional disorder;Genes;Genetic;Growth Factor;Human;Hydroxychloroquine;Imaging Device;Impairment;improved;Inflammation;Inflammatory;inhibitor;Injections;innovation;joint injury;Joints;KDR gene;Link;Liquid substance;Lymphatic;lymphatic drainage;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic function;Lymphatic System;lymphatic vessel;Lysosomes;Measures;Mediating;Mediator;Molecular;Morphology;mouse model;Mus;Names;normal aging;novel therapeutics;old mice;Osteitis;Pathogenesis;Pathology;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;physically handicapped;Play;Post-Translational Protein Processing;pre-clinical;Predisposition;prevent;Process;Production;protein expression;Proteins;Radiolabeled;Receptor Protein-Tyrosine Kinases;Reporting;Research;Rheumatoid Arthritis;Role;Sampling;Signal Transduction;subchondral bone;Swelling;Synovial Membrane;Synovitis;System;targeted agent;Testing;Therapeutic;Tissues;TNFSF11 gene;Tracer;transcriptome;Traumatic Arthropathy;Ubiquitination;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factor Receptor-3;Visualization

PROJECT_TITLE: Synovial lymphatics and osteoarthritis in aging

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: SAN CARLOS

ORG_NAME: SIOLTA THERAPEUTICS, INC.

PHR: NARRATIVE The human gut microbiota is a crucial environmental factor that influences the development of immune tolerance in childhood, thus making early-life live microbial interventions an attractive approach for allergic disease prevention. To this end, Siolta Therapeutics has developed a novel live biotherapeutic product, STMC-103H, for the prevention of allergic disease. Siolta aims to continue the innovative manufacturing development of the novel live biotherapeutic STMC-103H to support late-stage clinical and commercial development.

PI_NAMEs: VALLADARES, RICARDO  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acceleration;Acute;Allergens;Allergic;allergic airway inflammation;Allergic Disease;Allergic inflammation;Anaerobic Bacteria;analytical method;Anaphylaxis;Antioxidants;Asthma;Atmosphere;Atopic Dermatitis;Bacteria;Biochemical Pathway;Biological Markers;Biological Response Modifier Therapy;Bioreactors;capsule;Cells;Child;Childhood;Chronic;Clinical;clinical development;clinical efficacy;clinical material;Clinical Research;Clinical Trials;commensal bacteria;commercialization;comparison control;cost;Cyclic GMP;Data Set;Desiccation;design;Development;Disease;disease model;disorder prevention;disorder risk;Dryness;Economic Burden;Environmental Risk Factor;Eosinophilia;Evaluation;Excipients;Extrinsic asthma;Feces;Flow Cytometry;Food Hypersensitivity;Formulation;Freeze Drying;Freezing;global health;Goals;gut microbiota;healthcare burden;Human;Hypersensitivity;IgE;Immediate hypersensitivity;Immune;Immune Tolerance;Immunologics;immunoregulation;Impairment;improved;in vivo;Individual;Infant;Infiltration;innovation;Interleukin-4;Intervention;Lactobacillus;Licensing;Life;Link;liquid formulation;Lung;Lymph;manufacture;Mediating;member;Metagenomics;method development;Methods;Microbe;microbial;Molecular;Morbidity - disease rate;mouse model;novel;novel strategies;Onset of illness;Oral;Oral Administration;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phase I Clinical Trials;Phase II Clinical Trials;potency testing;Powder dose form;pre-clinical;prevent;Prevention;Primary Prevention;Probiotics;Process;process optimization;product development;Production;programs;Public Health;Quality of life;Reaction;Recovery;Regulatory T-Lymphocyte;Reporting;Risk;Secondary Prevention;standard of care;success;Supplementation;Symptoms;System;Temperature;Testing;Th2 Cells;Therapeutic;therapeutic candidate;Training;United States Food and Drug Administration;Update;Validation;Work

PROJECT_TITLE: Anaerobic Manufacturing and Molecular Analytical Process Optimization to Support Clinical Development of Live Biotherapeutic Products

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(10)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Our proposal addresses two major needs and gaps identified in the most recent National Eye Institute planning statement, namely (1) to "understand the molecular mechanisms and pathways in cone photoreceptors that have not been as extensively studied as rods", and (2) to "elucidate the molecular mechanisms that lead to photoreceptor degeneration". We will be using single-cell electrophysiology from mice with targeted gene deletions to investigate basic mechanisms in cone light sensitivity, and to identify the nature of the changes that occur during the course of cone photoreceptor degeneration. Our work should provide new information about the function and dysfunction of the cones, which are the cells in our eye primarily responsible for visual detection during most of our waking hours.

PI_NAMEs: FAIN, GORDON LEE (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Acceleration;Address;Affect;Behavior;Blindness;Cell Death;Cell Nucleus;Cell Physiology;Cells;Characteristics;Collaborations;Cone;connexin 36;Dendrites;Detection;Discrimination;Disease;Electrophysiology (science);Excision;Eye;Frequencies;Functional disorder;Gap Junctions;Gene Deletion;Genes;Goals;HCN1 channel;HCN1 gene;Hereditary Disease;Hour;Learning;Light;light effects;Lighting;mathematical model;Membrane;Membrane Potentials;Methods;Molecular;Motion;Mus;mutant;Mutant Strains Mice;Mutation;National Eye Institute;Nature;Noise;Paris, France;patch clamp;Patch-Clamp Techniques;Pathway interactions;Patients;Photophobia;photoreceptor degeneration;Photoreceptors;Physiological;Physiology;Primates;Process;Property;Proteins;Research;response;Rest;Retina;Retinal Cone;Retinal Degeneration;Retinitis Pigmentosa;Rod;Role;Shapes;Signal Transduction;Slice;Stimulus;Synapses;Techniques;Testing;Time;Vertebrate Photoreceptors;Vision;Visual;visual discrimination;Visual Perception;Visual System;voltage;voltage clamp;Work

PROJECT_TITLE: Physiology of Photoreceptors

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative Organic Photoredox Catalysts for Synthetic Method Development Garret M. Miyake, Colorado State University, Department of Chemistry The proposed research aligns with the mission of the NIH because it describes the development of technologies that will enable new chemical reactivity critical to advance the discovery and manufacturing of medicines and polymeric materials, ultimately enhancing human health. Through the mechanistically guided design of organic photoredox catalysts, the proposed work aims to eliminate the contamination and sustainability concerns posed by precious metal photoredox catalysts while unlocking unprecedented reactivity and mechanistic insights. As such, this proposal is broadly relevant to public health, as it will increase fundamental understanding of chemical systems, processes, and materials integral to medicine.

PI_NAMEs: MIYAKE, GARRET MORGAN (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acceleration;Achievement;Address;Catalysis;catalyst;chemical reaction;Chemicals;Chemistry;Colorado;design;Development;Dyes;Engineering;functional group;Future;Goals;Health;Human;improved;insight;Light;manufacture;Medical;Medicine;metal complex;Metals;method development;Methodology;Mission;novel;Oxidation-Reduction;Pathway interactions;Polymers;Process;Property;Public Health;Reaction;Reagent;Research;Research Activity;small molecule;Societies;System;technology development;United States National Institutes of Health;Universities;Work


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Microbiome;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: The proposed research focuses on prostate cancer, one of the most frequently diagnosed cancers in men in the United States, and will identify bacterial enzymes involved in androgen biotransformation and biosynthesis in addition to obtaining bacterial species harboring these enzymes. This knowledge will serve to develop novel agents acting as potential inhibitors for the bacteria themselves and/or their androgen related enzymes, which could have a major impact on prostate cancer progression due to androgen bioavailability from bacterial sources. The project supports the foundation of an innovative approach to slow or prevent prostate cancer progression.

PI_NAMEs: GHARAIBEH, RAAD  (contact);JOBIN, CHRISTIAN

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: absorption;advanced prostate cancer;Algorithms;Anabolism;androgen biosynthesis;androgen deprivation therapy;androgen independent prostate cancer;Androgen Metabolism;Androgens;Bacteria;Bacterial Genes;Bacteroides;Beta-glucuronidase;Bile fluid;Bioinformatics;Biological Availability;Bioreactors;cancer diagnosis;Cancer Etiology;Cancer Patient;Castrate sensitive prostate cancer;Cessation of life;Clinical;Clostridium;cohort;CYP17A1 gene;deprivation;Development;Disease;drug efficacy;drug metabolism;enzyme biosynthesis;Enzymes;Evaluation;Feces;Foundations;Future;Genes;Genomics;gut bacteria;gut microbiome;gut microbiota;Human;human male;Hydrocortisone;inhibitor;innovation;Interdisciplinary Study;Intervention;Intestines;Knowledge;Liver;MALDI-TOF Mass Spectrometry;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metabolic Biotransformation;metabolomics;metagenome;microbial;microbial genomics;microbiome;microorganism;Mus;novel;novel strategies;Operon;Orchiectomy;Organism;Outcome;Patients;Play;Pre-Clinical Model;prevent;Prevention strategy;Production;Prognosis;prostate cancer prevention;prostate cancer progression;Prostate Cancer therapy;Research;Resistance;Resistance development;Role;Route;Ruminococcus;Science;Serum;Shotguns;Source;Steroids;System;Talents;Testing;Testosterone;testosterone biosynthesis;treatment response;treatment strategy;tumor;United States;vpr Genes;whole genome;Work

PROJECT_TITLE: Deciphering microbial contribution to androgen bioavailability in castration resistant prostate cancer patients

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Pulmonary Fibrosis;Rheumatoid Arthritis;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: public health relevance in SARDs, affecting well over 20% of the general population. Further, the etiology and features of PASC in SARDs may be unique because of differences in their immune responses to infection and predisposition to autoimmunity and fibrosis.  These studies will comprehensively investigate the immunologic and clinical outcomes after COVID-19 in patients with SARDs. To achieve our aims, we have assembled a cohort of vaccinated SARDs, systematically identified all SARDs with COVID-19, and are prospectively enrolling patients into an observational study. In the first aim, we will investigate risk for breakthrough infection after vaccination among RA patients on immunosuppressants. We will follow SARO patients acutely infected with COVID-19 to determine whether immunosuppressants prolong viral shedding that may result in viral evolution. In the second aim, we will measure autoantibodies as well as antibodies to pathogens to determine changes induced by COVID-19 and identify antibody profiles associated with PASC among SARDs. In the third aim, we will obtain chest imaging and respiratory phenotyping to determine if COVID-19 may induce fibrotic lung disease in RA patients.  Dr. Jeffrey Sparks (Assistant Professor of Medicine at Brigham and Women's Hospital and Harvard Medical School, HMS) and Dr. Zachary Wallace (Assistant Professor of Medicine at Massachusetts General Hospital, HMS) will lead these studies as Principal Investigators. Dr. Sparks and Dr. Wallace are rheumatologists and research leaders related to SARDs and the COVID-19 pandemic. The PIs have assembled a cohort of all SARO patients with confirmed COVID-19 in the Mass General Brigham system, composed of 2 large tertiary care centers and 12 community hospitals. They are prospectively enrolling these patients after COVID-19 to study PASC. These studies have high potential for impactful results related to risk of breakthrough infection and formation of variants, determining humoral immune correlates of PASC, and determining how respiratory viral diseases may impact SARDs patients.

PI_NAMEs: SPARKS, JEFFREY ANDREW (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: 2019-nCoV;Acute;acute COVID-19;Affect;American;Antibodies;Antibody Response;Autoantibodies;autoimmune rheumatologic disease;Autoimmunity;B-Lymphocytes;Biophysics;breakthrough infection;Characteristics;Chest;Chest imaging;Clinical;cohort;Community Hospitals;Complication;Coronavirus;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pathogenesis;COVID-19 risk;COVID-19 sequelae;COVID-19 survivors;Data;Diagnostic;Disease;Disease Outbreaks;Dose;Effectiveness;Etiology;Evolution;Fibrosis;fibrotic lung disease;General Hospitals;General Population;High Resolution Computed Tomography;high risk;Hospitals;Humoral Immunities;Image;Immune;Immune response;Immunologics;Immunomodulators;Immunosuppressive Agents;Infection;inhibitor;Knowledge;Lead;Long COVID;Massachusetts;Measures;medical schools;Medicine;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Observational Study;Outcome;pandemic disease;participant enrollment;pathogen;Patients;Phenotype;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;Predisposition;Principal Investigator;professor;prospective;Prospective cohort;prototype;public health relevance;Pulmonary Fibrosis;Recommendation;Research;respiratory;Respiratory Signs and Symptoms;response;Retrospective cohort study;Rheumatoid Arthritis;rheumatologist;Risk;rituximab;RNA vaccine;Sampling;SARS-CoV-2 infection;Source;System;Systemic Lupus Erythematosus;tertiary care;therapy resistant;TNF gene;Vaccinated;Vaccination;vaccine immunogenicity;Vaccines;Variant;Viral;virology;Virus Diseases;Virus Shedding;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Immunologic and Clinical Sequelae after COVID-19 in Patients with Systemic Autoimmune Rheumatic Diseases

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Hearing Loss;Neurosciences;Prevention

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The strong and irreversible ototoxicity significantly limits the clinical usage of aminoglycosides, a class of highly potent, broad-spectrum antibiotics capable of treating multiple life-threatening infections. For this project we will investigate the molecular mechanisms underlying aminoglycoside ototoxicity. We anticipate providing new leads for the development of novel methods to prevent aminoglycoside-induced hearing loss.

PI_NAMEs: ZHAO, BO  (contact)

PROJECT_TERMS: Adverse effects;Adverse reactions;Affect;aminoglycoside-induced ototoxicity;Aminoglycosides;Antibiotics;Antibodies;Area;base;Binding;Binding Proteins;Biochemical;Biochemistry;Biological Assay;Cell Death;Cell Physiology;Cell Survival;Clinical;Cochlea;Data;Development;Dyes;Genes;Genetic;Gentamicins;Goals;Hair;Hair Cells;hearing impairment;Human;Immunoblot Analysis;Immunofluorescence Immunologic;in vivo;Infection;insight;Knockout Mice;Label;Labyrinth;Life;Link;link protein;live cell imaging;Maintenance;Mass Spectrum Analysis;mechanotransduction;Mediating;Methods;Mitochondria;Molecular;Morphogenesis;mouse model;Multi-Drug Resistance;Mus;Mutation;Names;new therapeutic target;normal hearing;novel;novel strategies;Organism;ototoxicity;Parkin;Pathologic;Pathway interactions;permanent hearing loss;pharmacologic;Physiological Processes;PINK1 gene;prevent;Prevention;Production;protein function;Proteins;Reactive Oxygen Species;Research;response;Role;screening;Sensory Receptors;Signal Pathway;Stains;Testing;therapeutic development;yeast two hybrid system;Yeasts

PROJECT_TITLE: Molecular Mechanisms of Aminoglycoside Ototoxicity


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Epilepsy;Gene Therapy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: LAY NARRATIVE Mutations in the sodium channel gene SCN8A result in a severe epileptic syndrome designated SCN8A-DEE, Developmental and Epileptic Encephalopathy, that is characterized by early onset seizures, profound intellectual disability, and impaired movement. We pioneered an antisense-oligonucleotide (ASO) drug treatment that prevents seizures and extends lifespan in a preclinical mouse model. We propose to develop improved viral and CRISPR treatments with longer-term effectiveness and reduced potential for side effects, and to elucidate the unexplored role of the cerebellum in the co-morbidities of movement and cognition in observed in individuals with SCN8A-DEE.

PI_NAMEs: MEISLER, MIRIAM H (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Action Potentials;adeno-associated viral vector;Affect;Alleles;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Ataxia;auditory stimulus;Brain;Brain region;Cerebellum;Child;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;Cognitive;comorbidity;CRISPR therapeutics;CRISPR/Cas technology;Dependence;Development;developmental disease;developmental epileptic encephalopathy;Disease;Dorsal;Down-Regulation;early onset;effective therapy;Effectiveness;effectiveness evaluation;Electroencephalography;Engineering;entorhinal cortex;Epilepsy;epileptic encephalopathies;excitatory neuron;exome sequencing;experience;experimental study;extend lifespan;Functional disorder;Funding;Future;gain of function mutation;gene therapy;Genes;Genetic;Goals;Heterozygote;Hippocampus;Human;Impairment;improved;In Vitro;Individual;Injections;insight;Intellectual functioning disability;Intervention;Knock-out;Length;Life;LoxP-flanked allele;Missense Mutation;Motor;motor impairment;mouse model;Movement;Mus;Muscle hypotonia;mutant;Mutation;Myoclonus;Nervous System Disorder;neuronal excitability;Neurons;novel strategies;novel therapeutics;Nucleotides;Pathogenicity;Pathology;Patients;Pharmaceutical Preparations;Pharmacotherapy;pre-clinical;prevent;Property;Prosencephalon;Purkinje Cells;Recurrence;Reporting;Research Personnel;response;Role;SCN8A gene;Seizures;side effect;small hairpin RNA;Sodium Channel;Source;standard care;Sudden Death;Syndrome;Thalamic structure;Therapeutic;Therapeutic Effect;therapeutic effectiveness;Therapeutic Intervention;therapeutically effective;Transcript;Transgenic Organisms;translational potential;Treatment Efficacy;Variant;Viral;Viral Vector;voltage;Work

PROJECT_TITLE: Functional Genetics of the Neuronal Sodium Channel Gene SCN8A

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative This project utilizes single-cell RNA sequencing data and a novel damage model that synchronizes the regenerative responses of supporting cells during proliferative sensory hair cell regeneration in the chicken hearing organ, the basilar papilla. Among the identified signaling pathways is one essential for S-phase entry of supporting cells during hair cell regeneration, and it is proposed to translate the findings towards adult mammals and evaluate regeneration in vestibular and cochlear organs. Finally, the re-establishment of proper hair cell-type specificity, hair bundle differentiation and function, tonotopic integration, and neural connection of regenerated avian hair cells will be characterized in-depth.

PI_NAMEs: HELLER, STEFAN  (contact)

PROJECT_TERMS: 3-Dimensional;activating transcription factor 3;Adult;Aminoglycosides;Appearance;Applications Grants;Basilar Papilla;Bioinformatics;Birds;Cell Death;Cell Maturation;cell regeneration;Cell Separation;cell type;Cells;Chickens;Cochlea;Compensation;Computer Analysis;Data;Dependovirus;Dose;DTR gene;Electrophysiology (science);Epidermal Growth Factor Receptor;Epithelium;Equipment and supply inventories;experimental study;Exposure to;FOSL2 gene;Future;G-Protein-Coupled Receptors;Gene Expression;Generations;Genes;Genetic Transcription;Goals;Hair;hair cell regeneration;Hair Cells;Hearing;Immunohistochemistry;In Situ;In Situ Hybridization;in vivo;Infusion procedures;insight;Labyrinth;Link;Location;Mammals;Measures;Methodology;Mitogen-Activated Protein Kinases;Mitotic;Modeling;mouse model;Mus;Natural regeneration;neural;novel;Organ;Organoids;ototoxicity;PAR-2 Receptor;Pathway interactions;Phosphorylation;planar cell polarity;Process;Reaction;Regenerative pathway;Regenerative response;reinnervation;repaired;Reporter Genes;response;S phase;Sensory;Sensory Hair;Signal Pathway;single-cell RNA sequencing;Specificity;STAT3 gene;Structure of posterior semicircular canal;Supporting Cell;Supporting Cell of Organ of Corti;Synapses;Time;transcription factor;transcriptomics;transdifferentiation;Transgenic Organisms;Translating;Translations;Up-Regulation;Utricle structure;Validation;vestibular system;Work

PROJECT_TITLE: Regenerative pathways in the avian cochlea


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative: Our ability to predict the sensory consequences of our actions plays a critical role in our day to day life. In the auditory system, such predictions assist us in listening to the sound of our own voice when we speak, allowing us to quickly correct any errors that we might detect. However, problems with this self-monitoring, for example after hearing loss, can lead to difficulties in speaking properly, and a better understanding of this process will lead to new approaches for hearing, speech, and other communication disorders.

PI_NAMEs: ELIADES, STEVEN J (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Address;Animals;Area;Auditory;Auditory area;auditory pathway;Auditory system;Behavior;Behavior Control;Behavioral;Callithrix;Callithrix jacchus jacchus;Code;Communication impairment;Compensation;Dorsal;dorsal visual stream;Exhibits;experimental study;Feedback;Frequencies;Goals;Hearing;hearing impairment;Human;insight;Life;Link;Location;Measures;Modality;Modeling;Monitor;Monkeys;Motor;neural;neural circuit;neuromechanism;Neurons;novel;novel strategies;Pathway interactions;pharmacologic;Play;Primates;Process;Production;Research;response;Role;Sensory;sensory cortex;sensory feedback;sensory input;sensory integration;sensory mechanism;Shapes;Signal Transduction;Site;sound;Speech;Stimulus;Structure;Testing;Time;ventral visual stream;vocal control;vocalization;Voice;Work

PROJECT_TITLE: Sensory Prediction in the Auditory Cortex during Vocal Production


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: TUCSON

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Food insecurity, poor nutrition, and economic disadvantage are critical social determinants of health that contribute to disparities in type 2 diabetes mellitus (T2DM), a serious diet-sensitive chronic disease affecting more than 20% of food insecure adults. There is a demonstrable need for food-focused interventions to address the diet quality of persons with, or at risk of, T2DM. Completion of our pilot study will produce recruitment, retention, adherence, and cost data for a future definitive randomized controlled clinical trial, bringing us closer to our long-term goal of a tested, efficacious model of diabetes care coordinated across Federally Qualified Health Centers and food bank networks.

PI_NAMEs: HINGLE, MELANIE DANIELA (contact)

PROGRAM_OFFICER_NAME: RAJAPAKSE, NISHADI

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Affect;American;Arizona;Behavior;Belief;Blood Glucose;blood glucose regulation;Body Weight;Carbohydrates;care coordination;care seeking;Certification;Chronic;Chronic Disease;clinically relevant;Collaborations;Communities;coping;Coping Skills;cost;County;COVID-19 pandemic;Custom;Data;design;diabetes control;diabetes educator;Diabetes Mellitus;diabetes self-management;Diet;dietary;Dietitian;Disease Management;Disparity;economic disparity;Education;education resources;Educational Intervention;Ensure;Evaluation;evidence base;Federally Qualified Health Center;Fiber;Food;Food Assistance Programs;food insecurity;Food Packaging;food resource;food security;fruits and vegetables;Future;glycemic control;Glycosylated hemoglobin A;Goals;Health;health related quality of life;Health Resources;Healthy Eating;Home;Household;Human Resources;improved;Incidence;Individual;Intake;Intervention;intervention program;Life Style;Low income;Low Income Population;Medical;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Neighborhood Health Center;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;nutrition;Nutritional;Nutritionist;Outcome;Participant;patient engagement;patient oriented;Patients;personalized medicine;Persons;Pharmaceutical Preparations;Pilot Projects;prevent;Problem Solving;Process;Public Health;Randomized;Randomized Controlled Clinical Trials;Recipe;Recommendation;recruit;Research;Resources;response;retention rate;Risk;Risk Reduction;Security;Self Care;Series;Severities;social factors;social health determinants;System;Testing;Underinsured;Uninsured;uptake;Visit;Waiting Lists;Work

PROJECT_TITLE: Food and Resources Expanded to Support Health and Type 2 Diabetes (FRESH-T2D)

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Callous-unemotional (CU) behavior is a multidimensional construct composed of low empathy, prosociality, and guilt behaviors that predicts severe conduct problems, violent crime such as homicide, victimization by peers, substance use disorders, and global impairment. This project will investigate the developmental neurobiology of emerging CU behavior (i.e., CU behavior and its precursors) by identifying neural correlates and risk and protective factors for emerging CU behavior during infancy and toddlerhood—when empathy, prosociality and guilt are rapidly developing. Elucidating the processes that underlie emerging CU in infancy and toddlerhood will have implications for informing the most promising targets of preventative intervention during developmental periods in which brain development and behavior may be most malleable.

PI_NAMEs: DONOHUE, MEGHAN ROSE (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 3 year old;Address;Adolescence;Adolescent;Affective;affiliative behavior;Age;Area;Auditory;Behavior;behavior prediction;Biological Markers;Birth;Brain;callous unemotional trait;Child;Child Rearing;Childhood;Clinical;Code;cohort;conduct problem;Development;developmental neurobiology;Dimensions;Distress;early childhood;early life adversity;Emotions;Empathy;Environment;Environmental Risk Factor;Event-Related Potentials;Exhibits;Exposure to;Financial Hardship;Fright;Funding;Guilt;Happiness;high risk;Homicide;Impairment;indexing;infancy;Infant;Intervention;Knowledge;Life;longitudinal analysis;longitudinal design;Maintenance;Maps;Measurable;Measures;Mental disorders;mental state;Mentors;Methods;Modeling;modifiable risk;Moral Development;Morality;Mothers;multidisciplinary;National Institute of Mental Health;neural;neural correlate;neurodevelopment;Neuronal Plasticity;Parents;Pathway interactions;Patient Self-Report;Pattern;peer victimization;Phenotype;pleasure;Poverty;prenatal;prenatal experience;prevent;Prevention;preventive intervention;Process;Prospective Studies;protective factors;Psychopathology;psychosocial;Public Health;remorseless;Reporting;Research Activity;Research Design;Research Domain Criteria;Rewards;Risk;Risk Factors;Risk Marker;Role;Sampling;Scientist;social;Social Problems;Social Processes;Stimulus;Stress;Substance Use Disorder;success;Symptoms;Techniques;Testing;theories;Training;Training Activity;United States National Institutes of Health;violent crime;virtual

PROJECT_TITLE: Neurodevelopmental Emergence of Callous-Unemotional Behavior Beginning in Infancy: Neural Markers and Environmental Risk and Protective Factors

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Individual social needs—including food, housing, and transportation—are associated with biopsychosocial outcomes in a range of contexts and populations, but clinicians need to know more about how social needs affect cancer patients and their informal caregivers. This study will examine how the social needs of breast and gynecologic cancer patients and their caregivers affect both patient and caregiver outcomes in the year after diagnosis. Findings will inform targeted screening and intervention efforts to addresses the mental health and social needs of patients and caregivers.

PI_NAMEs: THOMPSON, TESS  (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Academy;Address;Adherence;Affect;Anxiety;Area;biopsychosocial;Breast;cancer diagnosis;Cancer Patient;Caregivers;Caring;Censuses;Characteristics;Communities;depressive symptoms;deprivation;Diagnosis;Distress;Education;Emergency department visit;Emotional;experience;Family member;Food;food insecurity;Friends;Geography;Goals;Gynecologic;Health;health disparity;Health system;Housing;improved;improved outcome;Income;indexing;Individual;individual patient;informal caregiver;informal caregiving;interest;Intervention;Interview;Link;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Measures;member;men;Mental Health;Modeling;mortality;Neighborhoods;Newly Diagnosed;Outcome;Participant;Patient Self-Report;Patient-Focused Outcomes;Patients;physical conditioning;Population;Poverty;preference;primary outcome;psychological distress;Quality of Care;Quality of life;Race;Reduce health disparities;Reporting;Research;residence;Resources;screening;secondary outcome;Self Management;social;Social Conditions;Social Environment;social health determinants;social vulnerability;socioeconomic disadvantage;Socioeconomic Status;Structure;System;Testing;Time;Transportation;treatment adherence;United States;visit adherence;Woman;women patients;women's outcomes;Work

PROJECT_TITLE: Dyadic Analysis of Unmet Social Needs Among Breast and Gynecologic Patients and Their Informal Caregivers

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: PROJECT NARRATIVE Alzheimer’s disease and related dementias (ADRD) are a major cause of morbidity and mortality (6th leading cause of death in the United States). African American adults are at disproportionally high risk, and chronic inflammation may be a key biological risk factor. The proposed work will assess specific innate and adaptive immune cells, and genes expressed in these cells, and determine whether they are associated with mild cognitive impairment (MCI) and dementia risk among African Americans from the population-based Jackson Heart Study, as well as target genes and biological mechanisms in immune cells for genetic variants previously associated with dementia.

PI_NAMEs: RAFFIELD, LAURA M (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: adaptive immunity;Address;adjudication;Adult;African;African American;African American population;Age;age related changes;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;Amyloid;Anti-Inflammatory Agents;B-Lymphocytes;Biological;Biological Markers;Biology;Brain;brain magnetic resonance imaging;brain volume;C-reactive protein;Cause of Death;CD8-Positive T-Lymphocytes;cell type;Cells;Cellular Immunity;Cerebrovascular Disorders;childhood adversity;Chronic;Chronic stress;Cognition;cohort;Cohort Studies;Communities;comorbidity;cost;Data;database of Genotypes and Phenotypes;Dementia;dementia risk;Disease;Disease Outcome;Educational Status;Enrollment;European;European ancestry;experience;Funding;Gene Expression;Genes;Genetic;Genetic Transcription;genetic variant;genome wide association study;health disparity;high risk;Immune;immune activation;immune function;immune RNA;Immune system;immune system function;Immunologic Markers;Immunophenotyping;improved;Income;Inflammasome;Inflammation;Inflammatory;Interleukins;Jackson Heart Study;Light;Link;Lymphocyte;Magnetic Resonance Imaging;Measures;Mediating;Mediator;Memory;men;Mental Depression;Microglia;mild cognitive impairment;monocyte;Morbidity - disease rate;mortality;Nerve Degeneration;neurofilament;neuroinflammation;neuropathology;Neuropsychological Tests;normal aging;Not Hispanic or Latino;novel;older adult;Older Population;Outcome;Participant;participant enrollment;Pathogenesis;Pathway interactions;Peripheral Blood Mononuclear Cell;Phenotype;phenotypic data;Plasma;Population;population based;Population Study;Psychosocial Stress;Public Health;public repository;Quantitative Trait Loci;racism;Reporting;Research;Resource Sharing;Resources;Risk;Risk Factors;risk variant;RNA Splicing;Role;Sampling;senescent cell;sex;Sex Differences;Signal Transduction;social health determinants;Stress;T-Lymphocyte;tau-1;Therapeutic;therapeutic target;Time;Transcript;transcriptome;transcriptome sequencing;Underrepresented Populations;United States;Variant;White Matter Hyperintensity;Woman;Work

PROJECT_TITLE: Immune Cells in Alzheimer’s Disease and Related Dementias in the Jackson Heart Study


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative Dysregulated prefrontal cortex-dependent cognition is associated with multiple behavioral disorders. Our ability to treat this dysfunction is hindered by a limited understanding of the neural mechanisms that underly prefrontal dependent cognitive function. Towards this goal, and building on recent observations in our laboratory, the proposed studies take a multidisciplinary approach to better understand neural mechanisms involved in the cognitive actions of prefrontal corticotropin releasing factor (CRF) neurons and the underlying circuit mechanisms in male and female rats.

PI_NAMEs: BERRIDGE, CRAIG W (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Affect;Animals;antagonist;Attention;Attention deficit hyperactivity disorder;attentional modulation;base;Behavior;Behavior Disorders;Brain;Catecholamines;Code;Cognition;Cognitive;cognitive function;cognitive process;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;Development;Disease;Distal;Drug usage;executive function;Female;Functional disorder;Funding;Genetic;genetic approach;genetic manipulation;Glutamates;Goals;Human;Impaired cognition;Impairment;improved;Infusion procedures;insight;interdisciplinary approach;Laboratories;male;Medial Dorsal Nucleus;Methodology;multidisciplinary;nerve supply;neural;Neurobiology;neurochemistry;neuromechanism;Neurons;Neurotransmitters;novel;Ovarian;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;Pharmacological Treatment;Play;Prefrontal Cortex;Proestrus;Rattus;receptor;Regulation;Research;Role;Short-Term Memory;Steroids;sustained attention;Testing;Thalamic structure;treatment strategy;Viral Vector

PROJECT_TITLE: Prefrontal CRF and the Regulation of Goal Directed Behavior

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Tuberculosis (TB) preventive therapy reduces TB disease and death among people with HIV, even those receiving antiretroviral therapy. Despite 30 years of knowledge of the benefit of TB preventive therapy, it remains poorly implemented, with 10-30% of eligible individuals in low and middle income countries actually receiving it. The goal of this research is to test an implementation strategy based on choice architecture to make preventive therapy prescribing the routine, “default” approach and in doing so to overcome current barriers to prescribing during HIV care.

PI_NAMEs: HOFFMANN, CHRISTOPHER J (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adoption;Adult;Advocacy;Africa;Africa South of the Sahara;Anemia;antigen test;antiretroviral therapy;Architecture;Area;arm;Automobile Driving;behavioral economics;Caring;Cause of Death;Cessation of life;Characteristics;Clinic;Clinical;Cluster randomized trial;co-infection;Cognitive;cognitive load;Complex;Country;Cryptococcus;Decision Making;Disease;Drug resistance;Effectiveness;Eligibility Determination;Emergency Situation;Environment;experience;Exposure to;forgetting;Goals;Guidelines;Health;Health Personnel;Hepatotoxicity;HIV;Immunization;implementation fidelity;implementation intervention;implementation measures;implementation process;implementation strategy;improved;Incidence;Individual;International;Intervention;Interview;Knowledge;Leadership;Liver;low and middle-income countries;Maintenance;Measurement;Morbidity - disease rate;mortality;Outcome;Paper;Patient Compliance;patient oriented;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;prescription opioid;pressure;prevent;Prevention;Preventive therapy;primary outcome;Printing;Procedures;Process;programs;Provider;provider-level barriers;Questionnaires;Random Allocation;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Reporting;Research;Research Priority;Risk;Self Assessment;Services;Shapes;South Africa;South African;statistics;Structure;System;Testing;theories;Theory of Change;Time;trial comparing;Tuberculosis;Tuberculosis diagnosis;Uncertainty;United States National Institutes of Health;Work

PROJECT_TITLE: Prevent TB: Application of choice architecture to implement TB preventive therapy in South Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-G(91)]