ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Arctic;Natural Products

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE We propose to establish a Collaborative Program involving the basic research and development of the discorhabdin class of marine iminoquinone alkaloids as highly potent and selective controls for a diversity of diseases. Due to the lack of availability of the natural products through isolation from the Arctic sponges, studies have been designed to develop innovative natural product synthesis methodologies as well as assess and develop these highly unique alkaloid natural products as potential therapeutics. Aleutianamine possesses ideal features for the development of innovative synthesis methodologies and because the molecule is small, strained and may effectively penetrate unique tissue types and serve broadly as a model for effective disease management for a variety of diseases for which viable treatment options do not currently exist.

PI_NAMEs: HAMANN, MARK T (contact);TIUS, MARCUS ANTONIUS;VALERIOTE, FREDERICK AUGUSTUS

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Alaska;Aleutian Islands;Aleutians;Alkaloids;Anabolism;Applications Grants;Applied Research;Arctic Regions;Basic Science;bioactive natural products;Biodiversity;Biological;Biological Assay;Breathing;Cell Cycle;Cellular biology;Chemical Structure;Chemicals;Chemistry;cold temperature;Collaborations;Construction Materials;cytotoxicity;Data;deep ocean;design;Development;Disease;Disease Management;disorder control;drug development;drug discovery;Drug Kinetics;Environment;Evaluation;Expeditions;flexibility;Foundations;Generations;Grant;Harvest;High Pressure Liquid Chromatography;Homology Modeling;Human;iminoquinone;In Vitro;in vitro Assay;in vivo;Inflammation;Informatics;innovation;interest;Investigation;Lead;Life;Ligand Binding;Ligands;Malaria;marine;marine natural product;marine organism;member;metabolomics;Methodology;Methods;Microarray Analysis;Modeling;Molecular Biology;molecular modeling;National Oceanic and Atmospheric Administration;Natural Products;Natural Products Chemistry;neoplastic cell;novel;ocean ecosystems;Organism;Penetration;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;Phylogenetic Analysis;Play;Porifera;pressure;Productivity;Program Development;programs;Proteins;Proteomics;Recording of previous events;Recovery;Reporting;research and development;Route;Sampling;secondary metabolite;Solid;Structure;Structure-Activity Relationship;Surveys;Taxonomy;Territoriality;Testing;Therapeutic;Tissues;tool;ultraviolet irradiation;Viral Cancer;Virus Diseases;Water;Work;X-Ray Crystallography

PROJECT_TITLE: Synthesis and Optimization of the Aleutianamine Class of Alkaloids

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Services;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Life-threatening trauma exposures, including traumatic injuries requiring presentation to acute care medical settings, occur frequently in the US in the era of the COVID-19 pandemic, firearm proliferation, and extreme weather events, and are both a substantial source of individual suffering and a significant public health burden. The study team is proposing a randomized pragmatic trial of a brief stepped care intervention delivered from an acute care medical trauma center that may both reduce the symptoms of posttraumatic stress disorder and diminish emergency department health service utilization. The study team has established a track record of using evidence derived from pragmatic trials to influence American College of Surgeons Committee on Trauma regulatory policy through end-of-study policy summits, thus enhancing the public health impact of the investigative results for US trauma care systems nationwide.

PI_NAMEs: BULGER, EILEEN M;ZATZICK, DOUGLAS F (contact)

PROGRAM_OFFICER_NAME: FREED, MICHAEL C

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Address;Alcohol abuse;Alcohol consumption;alcohol intervention;alcohol screening;American College of Surgeons;Blinded;care systems;Caring;Clinical;collaboratory;college;comorbidity;comparison control;COVID-19 pandemic;Data;Development;Disease;Drug usage;Elements;Ethnography;Event;extreme weather;Feeling suicidal;Firearms;follow-up;Goals;Guidelines;Health;health care delivery;health service use;Health Services Research;Healthcare Systems;high risk;Hospitalization;implementation process;improved;Individual;injured;Injury;Inpatients;Intervention;Interview;Investigation;Latinx;Life;Managed Care;Mediator;Medical;Mental Depression;mental health center;Mental Health Services;National Institute of Mental Health;Outcome;pandemic disease;patient population;patient screening;Patients;Pharmaceutical Preparations;Policies;Policy Maker;Population;Post-Traumatic Stress Disorders;pragmatic randomized trial;pragmatic trial;Procedures;Process;Process Assessment;Proliferating;Protocols documentation;psychologic;Psychotherapy;Public Health;Quality of Care;Randomized;rapid technique;reduce symptoms;Research;Sampling;Science;Scientist;screening;Series;severe injury;Site;Site Visit;Source;Surveys;Survivors;symposium;Symptoms;systems research;Testing;Trauma;trauma care;trauma centers;trauma exposure;trauma surgery;Traumatic injury;treatment effect;United States National Institutes of Health

PROJECT_TITLE: A Deployment Focused Pragmatic Trial of Optimal Stepped Care Intervention Targeting PTSD and Comorbidity for Acutely Hospitalized Injury Survivors Treated in US Trauma Care Systems

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: AMHERST

ORG_DEPT: NEUROLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Despite innovations in diagnosis and management, stroke remains a major cause of disability and death in the US. We seek to understand how stroke-induced lung injury results in secondary brain injury. Our efforts to understand lung-brain coupling will provide new information regarding potential lung-targeted therapies for stroke.

PI_NAMEs: HALTERMAN, MARC W (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;acute stroke;airway inflammation;Alveolar;Antioxidants;Antiplatelet Drugs;Blood - brain barrier anatomy;Blood Vessels;Body System;Brain;Brain Injuries;cell type;cellular targeting;Cerebral Ischemia;cerebrovascular;Cessation of life;Chronic;Coupling;cytokine;Data;Development;Diagnosis;disability;Distal;Endothelium;Estrogens;Evolution;exhaustion;extracellular;Gatekeeping;Genetic Polymorphism;Glycocalyx;Goals;Heparin Binding;Immune;Immune response;Immunotherapy;Impairment;improved outcome;Inflammation;Inflammatory;Inhalation;innovation;insight;Intervention;Ischemia;Ischemic Brain Injury;Ischemic Stroke;Kinetics;Ligands;Lipid Peroxidation;Lung;lung injury;Mechanics;Mediating;mimetics;Molecular;mouse model;Mus;Neurologic;neuroprotection;neurovascular;neurovascular injury;novel;Organ;Pathologic;Pathology;Patients;Peripheral;Permeability;Play;post stroke;Predisposition;Pulmonary Pathology;receptor;Recombinants;Recovery;Regulation;Reperfusion Injury;Reperfusion Therapy;resilience;Respiratory Mechanics;response;Role;severe injury;sexual dimorphism;Stroke;stroke outcome;stroke risk;stroke therapy;Structure;Superoxide Dismutase;systemic inflammatory response;targeted treatment;Testing;Therapeutic;Work

PROJECT_TITLE: Lung-Brain Coupling and the Immune Response to Acute Ischemic Stroke

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative: Consumer reporting patient safety events (PSE) during transitions of care is expected to reduce the risks for poor outcomes and adverse events. We propose to address facilitators and barriers to consumer PSE reporting during care transitions, and develop a patient-oriented PSE reporting system for cancer patients to engage in medication event reporting, promoting safety and quality of care. Built upon the established feasibility of consumer reporting, this project is expected to be generalizable to all chronic conditions through enhanced self-management and engagement during transitions of care.

PI_NAMEs: GONG, YANG ;JIANG, YUN  (contact)

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: Patient Engagement in Reporting Medication Events during Transitions of Care

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Data Science;Genetics;Human Genome;Lung;Machine Learning and Artificial Intelligence;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE A key goal of this project is to detect the disease module of the chronic obstructive pulmonary disease (COPD) to improve our understanding of its pathogenesis and inform therapeutic treatment. The proposed research is relevant to public health because it enables us to systematically identify disease genes associated with COPD. Thus, the proposed research is relevant to NIH’s mission towards developing fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance human health and reduce illness.

PI_NAMEs: WANG, XUWEN  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Address;Advisory Committees;Airway Disease;airway obstruction;Area;Behavior;Biology;Cessation of life;chronic inflammatory lung disease;Chronic Obstructive Pulmonary Disease;cohort;Committee Members;Complex;computing resources;Data;deep learning;deep reinforcement learning;Detection;detection method;Dimensions;Disease;disease phenotype;DNA Methylation;Drug Targeting;Educational workshop;Environment;Epidemiology;Epigenetic Process;epigenomics;Feedback;Gene Combinations;gene product;Genes;Genetic;Genomics;Genotype;Goals;Health;Human;human disease;human interactome;improved;insight;Intervention;Ising model;Knowledge;Literature;Lung;Lung Diseases;Maps;Mathematics;medical schools;Medicine;meetings;Mentors;Messenger RNA;Methods;MicroRNAs;Mission;Modeling;Molecular;molecular marker;Morbidity - disease rate;mortality;mRNA Expression;Multiomic Data;multiple omics;Nature;Neighborhoods;Network-based;novel;Organism;Outcome;Pathogenesis;Pathway interactions;Performance;Phenotype;Physics;precision medicine;prevent;Process;protein protein interaction;Proteins;Public Health;Reporting;Research;Respiratory Disease;Science;skills;SNP genotyping;Statistical Data Interpretation;Structure of parenchyma of lung;synthetic data;Systems Biology;Teaching Hospitals;Testing;Therapeutic;Tissues;tool;Training;Training Programs;Translating;United States National Institutes of Health;vector;Weight;Whole Blood

PROJECT_TITLE: Statistical physics and network-based approaches for elucidating molecular biomarkers of COPD

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(OA)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative This proposal seeks support to develop novel data integration methods using electronic health records (EHR) from multiple CTSA hubs to create predictive models of multi-system diseases. We propose to develop the Predictive Analytics via Networked Distributed Algorithms (PANDA) framework, which will enable accurate risk prediction to help healthcare providers reach accurate diagnoses earlier.

PI_NAMEs: BIAN, JIANG ;CHEN, YONG  (contact);MERKEL, PETER A

PROGRAM_OFFICER_NAME: LEYVA, FRANCISCO

PROJECT_TERMS: accurate diagnosis;Address;Adopted;Algorithms;analytical tool;Area;Awareness;Clinical;clinical diagnosis;Clinical Medicine;clinical research site;Collaborations;Communication;Consumption;cost;Data;Data Aggregation;data hub;data integration;Data Science;data sharing;Development;Diagnosis;Diagnostic;Disease;Disease Outcome;Early Diagnosis;Electronic Health Record;expectation;Florida;Generations;Goals;Health;Health Personnel;Health system;implementation science;Incidence;individual patient;Institution;Intervention;Knowledge;Learning;Manuals;Medical;Methodology;Methods;Morbidity - disease rate;mortality;next generation;novel;operation;Patients;Pattern;pragmatic trial;predict clinical outcome;prediction algorithm;Predictive Analytics;predictive modeling;Prevalence;privacy preservation;Process;prototype;Provider;Psoriatic Arthritis;Rare Diseases;Reproducibility;Research;research clinical testing;Resources;risk prediction;Secure;Site;Software Engineering;success;Syndrome;System;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;Time;tool;Translational Research;Vasculitis;Wegener's Granulomatosis

PROJECT_TITLE: PANDA-MSD: Predictive Analytics via Networked Distributed Algorithms for Multi-System Diseases


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: DURHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Relevance: Mammalian cells use biological zip codes to transport mRNAs, which encode the information for the synthesis of proteins, to specific locations in the cell, so that proteins are made in their appropriate location. This RNA localization process is critical to early development, learning and memory, and at the level of the individual cell, to the secretion of hormones and neurotransmitters as well the cell surface localization of proteins functioning in signaling and cell-cell communication. The findings from this study are expected to reveal new mechanisms of RNA localization and identify conserved pathways that may be dysregulated in diseases of development, metabolism, and ageing.

PI_NAMEs: NICCHITTA, CHRISTOPHER V. (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Aging;Binding;Binding Proteins;Biochemical;Biogenesis;Biological;Biology;Cell Communication;Cell Culture System;Cell surface;Cells;crosslinking and immunoprecipitation sequencing;Development;Disease;Endoplasmic Reticulum;Gene Expression;Genes;Hormone secretion;in vivo evaluation;Individual;insight;Laboratories;Learning;Location;Mammalian Cell;Mediating;Membrane Proteins;Memory;Messenger RNA;Metabolism;Modeling;Neurotransmitters;Pathway interactions;Peptide Signal Sequences;posttranscriptional;Process;Protein Biosynthesis;protein function;Protein translocation;Proteins;Proteome;proteostasis;Regulation;Research;ribophorin I;ribosome profiling;Ribosomes;RNA;RNA-Binding Proteins;Role;secretory protein;Signal Recognition Particle;signal sequence receptor;Signal Transduction;Site;System;Testing;tissue/cell culture;trafficking;Transcript;transcriptome;transcriptome sequencing;Translation Initiation;Translational Regulation;Translations

PROJECT_TITLE: Mechanisms of RNA localization and translational regulation on the endoplasmic reticulum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Renal cell carcinoma (RCC) is the most common and also the most lethal type of the malignant urological tumors and has been increasing continuously for unknown reasons during the past decades in the U.S. This proposed study represents the first large, prospective, racially diverse population-based study to investigate the association between PFAS exposure and kidney cancer risk in the US general population. The findings of this study will inform the medical and public communities about the health effects of PFAS exposure and help regulators make sound, science-based decisions.

PI_NAMEs: LIPWORTH, LOREN ;ZHENG, TONGZHANG  (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Air;bioaccumulation;Black race;Blood;cancer risk;Case/Control Studies;Chemical Structure;Clear cell renal cell carcinoma;cohort;Cohort Studies;Communities;Community Health;comorbidity;computerized;consumer product;Data;dermal exposure;Development;Diabetes Mellitus;Diagnosis;Diagnostic;drinking water;Environment;Environmental Exposure;ethnic disparity;Ethnic Origin;experience;experimental study;exposed human population;Exposure to;Follow-Up Studies;Food Contamination;General Population;Health;Health Hazards;Health Professional;Hearing;Hispanic;Hispanic Community Health Study/Study of Latinos;Histologic;Human;Hypertension;Incidence;Individual;Industrial Product;Industrialization;Intake;Isomerism;Kidney;Knowledge;Length;Malignant - descriptor;man;Measurement;Measures;Medical;men;mortality;National Institute of Environmental Health Sciences;Nested Case-Control Study;Nurses' Health Study;Obesity;Observational Study;Occupational;Organ;Parents;Participant;Pattern;perfluorooctane sulfonate;perfluorooctanoic acid;Physicians;Plasma;pollutant;Poly-fluoroalkyl substances;Population;population based;Population Study;Process;Production;prospective;Prospective cohort;Prospective Studies;Prospective, cohort study;Public Health;Race;racial difference;racial disparity;racial diversity;Regulation;Renal Carcinoma;Renal Cell Carcinoma;renal damage;Research;Resistance;Resources;response;Risk;Risk Factors;Sampling;Science;Serum;Smoking;sound;Testing;Time;tumor;United States Environmental Protection Agency;urologic;Water;Woman;Work

PROJECT_TITLE: Perfluoroalkyl substances and risk of kidney cancer in US men and women

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative T cell acute lymphoblastic leukemia patients that fail to respond to glucocorticoid (GC) therapy often relapse and succumb to disease. We identified new GC-resistance genes and a subpopulation of slow-cycling leukemia cells that is present in patients who fail therapy and relapse. We will use this information to reverse GC resistance and interfere with dormancy to prevent relapse in children with leukemia.

PI_NAMEs: KELLIHER, MICHELLE ALICE (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Acute T Cell Leukemia;acute T-cell lymphoblastic leukemia cell;Adult Precursor T Lymphoblastic Leukemia;BTG2 Gene;Cell Adhesion;Cell Reprogramming;Cells;Chemoresistance;chemotherapy;Child;Childhood;Childhood Acute Lymphocytic Leukemia;Childhood Leukemia;Childhood Precursor T Lymphoblastic Leukemia;Chromatin;Chromatin Loop;chromosome conformation capture;Complex;Critical Pathways;Data;Development;Disease;Enhancers;estrogen-related receptor;Failure;Frequencies;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Glucocorticoid Receptor;Glucocorticoids;Goals;Heterogeneity;Human;improved;in vivo;Inflammatory;inhibitor;knock-down;Knowledge;Label;leukemia;leukemia initiating cell;leukemia treatment;Leukemic Cell;leukemogenesis;Lymphoid Cell;Malignant Neoplasms;Measures;Mediating;Mitotic;Modeling;mRNA Stability;Mus;Natural regeneration;new therapeutic target;notch protein;NOTCH1 gene;novel;Nucleosomes;Oncogenic;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;Polycomb;Population;prevent;progenitor;prognostic indicator;programs;promoter;Property;prospective;receptor binding;Recording of previous events;Relapse;relapse patients;relapse prevention;Repressor Proteins;Research;Residual Neoplasm;Resistance;resistance gene;Resolution;response;Selection for Treatments;self-renewal;single-cell RNA sequencing;Small Interfering RNA;stem cells;T-Lymphocyte;TAL1 gene;targeted treatment;Testing;therapy resistant;Thymus Gland;transcriptomics;Translating;Treatment Failure;treatment response;Work

PROJECT_TITLE: Mechanism(s) of TAL1- and NOTCH1-mediated Leukemogenesis

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because it focusses on elucidating the molecular mechanisms underlying glutamatergic synapse function in inhibitory interneurons, a synapse that is implicated in many mental health disorders. This research could yield innovative strategies to boost glutamatergic synapse function in inhibitory interneurons, providing new therapeutic approaches to tackle psychiatric disease and neurological disorders. Therefore, the proposed research is relevant to the NIH's mission that pertains to protecting and improving health.

PI_NAMEs: BYGRAVE, ALEXEI MANSFIELD (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Ankyrin Repeat;Area;Basic Science;Behavior;Binding Proteins;Biochemical;Biology;Brain;career;career development;Cell Physiology;cell type;Complex;Coupled;Data;Data Set;Dendritic Spines;Diffusion;Dimensions;Disease;DLG4 gene;Electrophysiology (science);excitatory neuron;expectation;Functional disorder;Glutamates;Goals;Health;Hippocampus;Imaging Techniques;improved;innovation;insight;Interneurons;Investigation;Knock-out;Knowledge;Link;Liquid substance;Mass Spectrum Analysis;Mental disorders;Mentors;Mission;Molecular;Nervous System Disorder;neural circuit;Neurons;novel;novel therapeutic intervention;Outcome;overexpression;Parvalbumins;Phase;Phosphoric Monoester Hydrolases;Phosphotransferases;Physiology;Positioning Attribute;Process;Property;Proteins;Public Health;Regulation;Research;risk variant;scaffold;Shapes;Signal Transduction;skills;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;targeted treatment;tenure track;Testing;Therapeutic Intervention;Training;United States National Institutes of Health

PROJECT_TITLE: Molecular basis of glutamatergic synapse function in inhibitory interneurons


ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE High blood pressure can lead to heart attacks, strokes, and kidney failure, amongst other outcomes. Controlling high blood pressure can be achieved through changes in behavior combined with medications. The public health component of this study will be to understand how engaging people through an application on their phones and computers can help them to control their blood pressure and decrease these poor health outcomes.

PI_NAMEs: DORR, DAVID A. (contact);KOOPMAN, RICHELLE J

PROGRAM_OFFICER_NAME: TERAN, MARIO

PROJECT_TITLE: Collaboration Oriented Approach to Controlling High blood pressure (COACH)


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Housing policies enacted during the COVID-19 pandemic—including eviction moratoriums, emergency rental assistance, and legal representation to tenants facing eviction—impacted millions of households experiencing and at risk for housing insecurity. This study assesses to what extent these policies affected the receipt of substance use treatment and overdose risk.

PI_NAMEs: EISENBERG, MATTHEW  (contact);POLLACK, CRAIG EVAN

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Accident and Emergency department;Achievement;addiction;Address;administrative database;Affect;Ambulatory Care;Behavioral;Buprenorphine;Centers for Disease Control and Prevention (U.S.);Color;Communities;Costs and Benefits;Counseling;COVID-19;COVID-19 impact;COVID-19 pandemic;Data;Data Sources;Death Rate;Delaware;design;Drug usage;Emergency Situation;Ensure;Epidemiology;Ethnic Origin;evidence base;experience;Fatality rate;FDA approved;Funding;Health Care Costs;health economics;health service use;Health Services Research;Household;Housing;improved;Income;Individual;innovation;Inpatients;interest;Intervention;Interview;Knowledge;Legal;Life;Life Expectancy;Maryland;Measures;Medical;medical specialties;Methadone;Methods;Naltrexone;opioid use disorder;Outcome;Overdose;overdose death;overdose risk;pandemic disease;Pennsylvania;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Policies;Policy Developments;Policy Maker;Policy Research;Population;population based;post-pandemic;prevent;Provider;psychiatric comorbidity;public health emergency;Qualitative Methods;Race;Recording of previous events;Recovery;relapse risk;Research;Risk;rural counties;Security;service programs;service providers;Services;Speed;Structural Racism;Structure;substance use;Substance Use Disorder;substance use treatment;supported housing;Time;treatment and outcome;treatment risk;treatment services;Variant;West Virginia

PROJECT_TITLE: Housing Policies and their Impact on Engagement in Substance Use Treatment and Overdose Risk during the COVID-19 Pandemic


NIH_SPENDING_CATS: Neurosciences;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative: Neurodevelopmental disorders, including microcephaly and autism, as well as neurodegenerative diseases, including Alzheimer’s, and cancer result in significant human suffering and impose significant annual costs on the US health care system and society as a whole. This proposal seeks to understand how diet influences neural stem cell proliferation decisions during development. Neural stem cells are the cells that make all the neurons in the brain. Results garnered from this research will stimulate new discoveries in translational stem cell research in the context of normal development and disease states.

PI_NAMEs: SIEGRIST, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Adult;Affect;Alzheimer's Disease;autism spectrum disorder;Behavior;Brain;Cell division;cell type;Cells;Complex;Consumption;cost;Dependence;Development;Diet;dietary;Disease;Drosophila genus;Drosophila melanogaster;Genetic;Goals;Healthcare Systems;Human;insight;Intrinsic factor;Learning;Location;Malignant Neoplasms;Maps;mature animal;Memory;Microcephaly;model organism;Molecular;Morphology;nerve stem cell;neural circuit;neuroblast;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;neuroregulation;Nutrient;Nutrient availability;Pathway interactions;PIK3CG gene;Population Heterogeneity;programs;Proliferating;Research;response;Series;single cell sequencing;Societies;Specific qualifier value;stem cell proliferation;Stem Cell Research;Techniques;Time;transcription factor

PROJECT_TITLE: Nutrient-dependent regulation of neural stem cell proliferation and neural circuit formation


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CORAL GABLES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE We will map the parts of the African and Amerindian genomes that regulate the functions of the genes and contribute to disease. This has not been done before for these ancestries and needed to understand how genes cause Alzheimer Disease in African American and Hispanic populations. Identifying genes will lead to high quality genetic targets for the treatment of Alzheimer Disease.

PI_NAMEs: DYKXHOORN, DEREK MICHAEL;GRISWOLD, ANTHONY JOHN;VANCE, JEFFERY MARVIN (contact);YOUNG, JUAN ISAAC

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Affect;African;African American;African American population;African ancestry;Alzheimer's Disease;Alzheimer's disease risk;Americas;Amerindian;Architecture;Area;Astrocytes;ATAC-seq;Automobile Driving;Autopsy;Brain;brain tissue;Candidate Disease Gene;Caribbean region;causal variant;Cell Nucleus;cell type;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR interference;CRISPR-mediated transcriptional activation;Data;Databases;Disease;Enhancers;Ethnic Population;European;European ancestry;Female;Freezing;frontal lobe;functional genomics;Future;Gene Activation;gene function;gene interaction;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;Genome;genome editing;genome wide association study;genomic data;genomic locus;Genomic Segment;Genomics;Genotype-Tissue Expression Project;Haplotypes;Hi-C;Hispanic Populations;Human Genome;induced pluripotent stem cell;Intervention;Investigation;Knowledge;Latino Population;male;Maps;Microglia;Molecular;Neurons;Not Hispanic or Latino;Oligodendroglia;Pathway interactions;Peruvian;Population;Population Heterogeneity;promoter;racial population;rare variant;Resources;Risk;risk variant;Sampling;targeted treatment;Techniques;Therapeutic Intervention;transcriptome sequencing;Universities;Untranslated RNA;XCL1 gene

PROJECT_TITLE: Functional genomic studies in diverse populations to characterize risk loci for Alzheimer Disease


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Mental Illness;Rehabilitation;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Fear of cancer recurrence (FCR) is a highly prevalent, disruptive, and under-treated problem for breast cancer survivors. This randomized controlled trial will test the efficacy of group-based Acceptance and Commitment Therapy compared to Cognitive Behavioral Therapy and enhanced usual care for breast cancer survivors suffering from FCR while examining its cost-effectiveness and the mechanisms by which the intervention may work. Study findings will guide the future care of breast cancer survivors with FCR.

PI_NAMEs: JOHNS, SHELLEY A. (contact)

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Acceptance Process;active comparator;Address;Affect;Aftercare;Anxiety;arm;Attention;behavior change;Breast Cancer survivor;cancer recurrence;Cancer Survivor;Caring;Clinical;clinical practice;clinically significant;Cognitive Therapy;Colorectal;Colorectal Cancer;comparative;Comprehensive Health Care;coping;cost;cost effective;cost effective intervention;cost effectiveness;Databases;depressive symptoms;design;Disease remission;Distress;Early treatment;Education;efficacy testing;Elements;Eligibility Determination;Ethnic Origin;evidence base;Evidence based treatment;experience;Feeling;flexibility;follow-up;Fright;Future;Goals;Health;Health behavior;Health Services;Healthcare;Hour;improved;Indiana;Intervention;Malignant Neoplasms;Mediating;Mediator;Meta-Analysis;mindfulness;Moods;Morbidity - disease rate;mortality;neoplasm registry;Oncology;Outcome;Patient Care;Pattern;Persons;Phase;pilot trial;Population;post intervention;post-traumatic symptoms;primary outcome;Process;Prostate;psychologic;Quality of life;Race;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Recurrence;relative effectiveness;Reporting;Sampling;secondary outcome;Self Administration;standard care;stressor;Support Groups;Survivors;survivorship;Testing;Therapeutic Intervention;Thinking;Time;treatment as usual;Treatment Efficacy;United States;Videoconferencing;Work

PROJECT_TITLE: Acceptance and Commitment Therapy for Fear of Recurrence in Breast Cancer Survivors

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: POMONA

ORG_NAME: WESTERN UNIVERSITY OF HEALTH SCIENCES

ORG_STATE: CA

PHR: Project Narrative HIV is able to avoid detection and elimination by the immune system as part of its main methods to survive inside a person. This proposal aims to understand how HIV targets components of the immune system to disarm the innate immune system to stay inside a person living with HIV.

PI_NAMEs: SANCHEZ, DAVID JESSE (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: adaptive immunity;Amino Acid Motifs;antiviral immunity;arm;Biochemical;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Cellular biology;Cellular Immunity;cellular targeting;cytokine;Cytokine Receptors;Cytokine Signaling;Data;Dendritic Cells;Detection;domain mapping;experience;Genes;Goals;HIV;HIV Infections;immune clearance;Immune response;Immune system;Immunity;Infection;Innate Immune Response;Innate Immune System;insight;Interferon Type I;Interferon Type II;Interferons;JAK1 gene;Link;Lysosomes;Maps;Mediating;Methods;multicatalytic endopeptidase complex;Mutation Analysis;Names;Natural Immunity;Outcome;Pathogenesis;Patients;Persons;Phenotype;Phosphorylation;Production;Proteins;Refractory;Research Project Grants;response;Serum;Signal Transduction;STAT1 gene;System;T-Lymphocyte;Techniques;Tertiary Protein Structure;tumor-immune system interactions;Ubiquitination;Viral;Virus;Virus Diseases;Virus Replication;vpu Protein;Work

PROJECT_TITLE: HIV Redirecting Innate Immunity by Vpu Targeting of JAK1

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE (PUBLIC HEALTH STATEMENT) As the leading cause of cancer death, lung cancer represents the most significant cancer-related public health challenge in the United States. Despite significantly greater risk, Hispanics patients experience a robust survival advantage relative to non-Hispanic Whites. This project seeks to test hypothesized sociocultural resilience factors to inform targeted intervention strategies.

PI_NAMEs: HAMANN, HEIDI ANN;RUIZ, JOHN M (contact)

PROGRAM_OFFICER_NAME: ACEVEDO, AMANDA MARIE

PROJECT_TERMS: Acculturation;Adopted;Affective;Age;Behavioral;Black race;burden of illness;Cancer Etiology;Cancer Patient;cancer survival;Cancer Survivorship;Cellular Phone;Cessation of life;Clinical;Computerized Medical Record;cultural values;Data;Death Rate;demographics;Diagnosis;Early Diagnosis;Ecological momentary assessment;ethnic difference;ethnic minority;Ethnic Origin;Ethnic Population;experience;Family;follow-up;Fostering;Frequencies;Health;health care disparity;health economics;health related quality of life;Health Sciences;Hispanic;Hispanic Populations;in vivo;Incidence;Individual;innovation;Intervention;Interview;Investigation;Life;Longitudinal, observational study;low dose computed tomography;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Measures;Mediating;Mediator;Medical;Methodology;Methods;Morality;mortality;Neighborhoods;Non-Small-Cell Lung Carcinoma;Not Hispanic or Latino;novel;Outcome;Patient Self-Report;Patients;Persons;primary outcome;Process;psychosocial;Public Health;Publishing;Race;racial minority;recruit;Reporting;Research Personnel;resilience;resilience factor;resilience research;Risk;Risk Factors;Role;Sampling;Science;screening;secondary outcome;Site;social;social culture;Social Environment;social integration;Social Interaction;Social Processes;Social support;socioeconomics;Spanish/English;Surveys;survival disparity;survival outcome;Survival Rate;Testing;Time;treatment adherence;Underserved Population;United States;Variant;Work

PROJECT_TITLE: Ethnicity and Lung Cancer Survival: A Test of the Hispanic Sociocultural Hypothesis

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE: There are major gaps of knowledge in the understanding of how cell fate decisions are controlled to form airways or alveoli during development, and how the adult injured lung proceeds to undergo normal regeneration or abnormal dysfunctional repair. This proposal investigates these issues, examining mechanisms of cell plasticity and their implications in human diseases using mouse models, organoid technology and epidemiological data. Results from these studies will provide relevant insights into lung development and disease-repair processes for therapeutic interventions. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: CARDOSO, WELLINGTON V. (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Address;Adult;Alveolus;Behavior;Biology;Cell Compartmentation;Cells;Chronic Disease;Chronic Obstructive Pulmonary Disease;cohort;Development;Disease;epidemiologic data;epithelial stem cell;fetal;Future;genetic epidemiology;Genetic Models;Growth;Human;human disease;insight;intrauterine environment;Knowledge;Link;Lung;lung development;Lung Diseases;lung injury;lung repair;mouse genetics;mouse model;Natural regeneration;neonatal airway;neonatal human;Organoids;Perinatal;prevent;Process;progenitor;programs;Pulmonology;Regulation;repaired;Research Proposals;Resolution;stem cells;Technology;Therapeutic Intervention

PROJECT_TITLE: Regulation of Progenitor Cell Plasticity in Lung Development and Disease-Repair


ADMINISTERING_IC: EY

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEW HAMPSHIRE

ORG_STATE: NH

PHR: PROJECT NARRATIVE The proposed research seeks to understand the functioning and regulation of the photoreceptor phosphodiesterase enzyme (PDE6) and the proteins with which it interacts during visual signaling in retinal rod and cone photoreceptors. The work is relevant to the mission of the Retinal Diseases Program of the National Eye Institute because it will enhance our ability to predict whether genetic mutations of photoreceptor genes will result in visual disorders or blindness (e.g., retinitis pigmentosa, congenital stationary night blindness), as well as accelerate development of personalized therapeutic treatments for retinal diseases arising from defects in the proteins responsible for regulating the visual signaling pathway in the retina.

PI_NAMEs: COTE, RICK H (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Acceleration;achromatopsia;Allosteric Regulation;alpha Subunit Transducin;Architecture;Binding;Blindness;Catalytic Domain;clinically significant;Code;Communication;Complex;Cone dystrophy;Coupled;Darkness;Defect;Development;dimer;Disease;disease-causing mutation;DNA Sequence Alteration;Docking;Enzymes;Etiology;Event;Genes;Goals;GTP Binding;GTP-Binding Protein Regulators;GTP-Binding Proteins;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Heterotrimeric GTP-Binding Proteins;Inherited;Light;Lighting;Link;Mediating;Mission;Modeling;Molecular;Molecular Conformation;Molecular Target;Multienzyme Complexes;Mutation;National Eye Institute;next generation sequencing;Night Blindness;Outcomes Research;Pathogenicity;Pathway interactions;personalized therapeutic;phosphoric diester hydrolase;photoactivation;Photoreceptors;Phototransduction;Process;programs;Proteins;Recovery;Regulation;Research;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;Retinal Dystrophy;retinal rods;Retinitis Pigmentosa;RGS9 protein;Rod;Signal Pathway;Signal Transduction;Site;Speed;Therapeutic Intervention;Transducin;Vertebrate Photoreceptors;Vision Disorders;Visual;Work

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE We will examine the associations of structural racism and neighborhood attributes of disinvestment with smoking status and internal dose as well as lung cancer risk with an emphasis on inequities across race/ethnicity and socioeconomic status. The proposed study will be conducted among over 272,000 participants from the Multiethnic Cohort Study and Southern Community Cohort Study.

PI_NAMEs: CHENG, IONA C (contact);PARK, SUNGSHIM LANI

PROGRAM_OFFICER_NAME: MOMIN, BEHNOOSH RAMJI

PROJECT_TERMS: Address;Adult;African American population;Air Pollution;American;Biological;Biological Factors;Biological Markers;Biometry;Blood;cancer epidemiology;cancer health disparity;cancer risk;cigarette smoke;cigarette smoking;cohort;Cohort Studies;Communities;Development;DNA Methylation;Dose;Economics;Ensure;Environment;environmental stressor;Epidemiology;epidemiology study;Epigenetic age;Epigenetic Process;epigenome;epigenome-wide association studies;ethnic bias;ethnic difference;ethnic disparity;Ethnic Origin;Ethnic Population;European;experience;Exposure to;follow-up;former smoker;Genetic;Genetic Predisposition to Disease;Geographic Locations;Geography;Health Benefit;health care availability;health equity;health inequalities;high risk;high risk population;Histology;Incidence;Individual;Inequity;Intervention;Japanese American;Knowledge;Latin American;Leukocytes;lifestyle factors;Low Prevalence;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Methylation;Modification;Molecular;Molecular Epidemiology;multi-ethnic;multidisciplinary;Native Hawaiian;Neighborhoods;Nested Case-Control Study;Participant;Pathway interactions;Policy Maker;population based;Poverty;Prospective Studies;Public Health;Questionnaires;Race;racial difference;racial population;recidivism;Reporting;residential segregation;Resources;Risk;Role;rural setting;Sampling;Scientist;sex;Shapes;Site;Smoker;Smoking;Smoking Behavior;smoking intervention;Smoking Status;social factors;social health determinants;Socioeconomic Status;socioeconomics;structural determinants;Structural Racism;surveillance data;Testing;Tobacco;Tobacco-Associated Carcinogen;Tumor stage;urban setting;urinary

PROJECT_TITLE: Understanding the role of structural racism on racial/ethnic inequities in lung cancer risk


NIH_SPENDING_CATS: Wound Healing and Care

ORG_CITY: ALBANY

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: PROJECT NARRATIVE The proposed project will combine in vitro and in vivo approaches to elucidate the molecular mechanism(s) required by cancer and immune cells for migration in confining environments. Our goal is to identify molecular mechanism(s) that can be therapeutically targeted to prevent or abate the migration of unhealthy (cancerous) but not healthy (immune) cells.

PI_NAMEs: LOGUE, JEREMY S (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Abate;Actins;Adopted;Bulla;Bundling;cancer cell;Cancerous;cell motility;cell type;Cells;Development;Embryonic Development;Environment;Friction;Goals;Immune;Immunologic Surveillance;In Vitro;in vivo;Malignant Neoplasms;Mechanics;Methods;migration;Molecular;Neoplasm Metastasis;Phenotype;prevent;Proteins;Research Personnel;therapeutic target;Tissues;Work;wound healing

PROJECT_TITLE: Molecular Mechanisms of Confined Cell Migration

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: MADISON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Individual aging is the outcome of biological configuration and socioeconomic conditions and experiences. Aggregate population aging alters individual aging as it generates conditions that affect social organization, health services, and macro-economic change. CDHA helps to investigate these issues as an innovative and flexible provider of research products, training, and infrastructure for sharing scientific insights.

PI_NAMEs: ENGELMAN, MICHAL  (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Advocate;Affect;Aging;aging demography;aging population;aging related;Architecture;Attention;Awareness;biodemography;Biological;Biological Markers;Biological Process;Biomedical Research;Birth Place;care delivery;Caring;Cognitive;Collaborations;college;Communities;computer infrastructure;Computer software;Data;data acquisition;Data Analytics;data centers;Data Collection;data enclave;data library;data resource;Data Set;Demography;design;Deterioration;Development;disability;Ecology;Economic Conditions;economic outcome;Economics;Educational workshop;Epidemiology;epidemiology study;Epigenetic Process;Evaluation;Event;experience;Extramural Activities;Faculty Recruitment;faculty support;Family;fetal programming;flexibility;Foundations;Future;gene environment interaction;Genetic Processes;Geography;Goals;Graduate Education;Growth;Health;health economics;Health Services;Health Services Research;Health Status;high risk;Hormonal;Hospitals;improved;Individual;Infrastructure;innovation;insight;Institution;interest;Knowledge;late life;Lead;Leadership;Letters;Life Cycle Stages;Link;Longitudinal Studies;microbiome;middle age;Monitor;mortality;multidisciplinary;Outcome;Pilot Projects;Play;Policies;Policy Maker;prenatal;Professional Organizations;Program Development;programs;Provider;Research;Research Activity;Research Assistant;Research Infrastructure;Research Priority;Research Project Grants;Research Support;Resources;response;Role;Rural;Science;Scientist;Secure;senescence;Services;Shapes;social;social organization;Social outcome;Social Processes;sociodemographic disparity;socioeconomics;symposium;Technology;Text;tool;Training;Training Programs;United States National Institutes of Health;Universities;Update;Variant;Vision;Visit;Wisconsin;Work

PROJECT_TITLE: Center for Demography of Health and Aging


NIH_SPENDING_CATS: Aging

PHR: Project Narrative Per funding announcement instructions, the narrative is located in the Overall section of this proposal.

PROJECT_TERMS: Access to Information;Advocate;Aging;aging process;Agreement;Area;Award;Budgets;Collaborations;Communication;Data;data access;Data Storage and Retrieval;Database Management Systems;Demography;Development;doctoral student;Educational workshop;Ensure;Event;Expenditure;experience;Extramural Activities;Facebook;Faculty;Financial Support;Fostering;Funding;Funding Agency;graduate student;Grant;Group Meetings;Health;human subject protection;improved;Individual;Infrastructure;Institution;Institutional Review Boards;Instruction;meetings;Mission;Monitor;Newsletter;Occupational activity of managing finances;Office of Administrative Management;Organization and Administration;Periodicals;Policies;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Preparation;Productivity;programs;Publications;PubMed;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Resources;Scientific Advances and Accomplishments;Series;Services;social genomics;social media;Source;Special Event;Students;symposium;synergism;System;Training;Training Activity;Training and Infrastructure;training opportunity;Training Programs;Travel;Twitter;United States National Institutes of Health;Visit;web site;Work;working group

PROJECT_TITLE: Administrative and Research Support


NIH_SPENDING_CATS: Genetics;Human Genome;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Genomic DNA is packaged into a compact form around chromatin, which is a highly organized complex of DNA and proteins that needs to be reorganized by chromatin remodelers to enable biological processes such as gene expression, DNA replication, and DNA damage repair. Recent human genetic findings have indicated that mutations in genes encoding chromatin remodelers are an important contribution to disorders of brain development, including autism spectrum disorder and intellectual disability. In this study, we seek to understand the distinct functions of chromatin remodeling in gene expression and DNA damage and repair, and the consequences of their disruption on the development of the brain.

PI_NAMEs: KWAN, KENNETH YU-CHUNG (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: autism spectrum disorder;Biological Assay;Biological Process;Biology;Brain;Brain Diseases;Cell division;cell fate specification;Cells;Chromatin;chromatin remodeling;Complex;Detection;Development;Developmental Process;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA fiber assay;DNA Repair;DNA Repair Pathway;DNA replication fork;Double Strand Break Repair;experimental study;fetal;flexibility;Functional disorder;functional genomics;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;genome integrity;Genome Stability;Genomic DNA;Genomics;Goals;Histones;homologous recombination;Human Genetics;Impairment;in vivo;Intellectual functioning disability;Literature;Maintenance;Measures;Mediating;model of autism spectrum disorder;Molecular;mutant;Mutation;nerve stem cell;Neuroanatomy;neurodevelopment;Neurodevelopmental Disorder;neurodevelopmental effect;Neuroglia;Neuronal Plasticity;Neurons;Nonhomologous DNA End Joining;Nuclear;Nucleosomes;Paper;Pathway interactions;Phenotype;Play;Positioning Attribute;Process;protein complex;Proteins;recruit;Regulation;repair function;repaired;replication stress;Resolution;response;Role;single molecule;Somatic Mutation;stem cell division;stem cells;Testing;TP53 gene;Transcriptional Regulation;transcriptome;transcriptomics;Variant;virtual;Work;YY1 Transcription Factor

PROJECT_TITLE: Distinct roles of chromatin regulation in transcriptome and genome maintenance in corticogenesis

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Aging;Clinical Research

PROJECT_TITLE: Program Development (Pilot) Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Burden of Illness

PI_NAMEs: FISS, CHARLES ROBERT (contact)

PROJECT_TITLE: External Innovative Network Core


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STONY BROOK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative: Glioblastoma (GB), the most common primary CNS tumor in adults, is surrounded by an immunosuppressive microenvironment through the recruitment of myeloid cells. This proposal seeks to harness the anti-cancer po- tential of myeloid cells by targeting Neuropilin-1 (NRP1) in an effort to curb the growth of this intractable tumor type. The studies will contribute to the fundamental knowledge of how the innate immune system modulates GB growth, and how tumor-associated myeloid cells could be targeted to create new GB therapies.

PI_NAMEs: RADIN, DANIEL  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Ablation;Adopted;Adult;Affect;angiogenesis;Angiogenesis Inhibition;Angiogenic Factor;anti-cancer;Anti-Inflammatory Agents;Area;Behavior;Binding;Breast Cancer Model;Cell Communication;Cell Proliferation;Cells;Central Nervous System Neoplasms;chemokine;chemoradiation;chemotherapy;Complex;Conditioned Culture Media;cytokine;Data;exhaust;experimental study;Fostering;Genes;Genetic Transcription;Glioblastoma;Glioma;glioma cell line;Goals;Growth;Hypoxia;Immune;Immune Evasion;Immunocompetent;Immunosuppression;in vivo;inflammatory marker;inhibitor;Innate Immune System;Knock-out;Knowledge;Laboratories;Macrophage;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Mediating;Mediator;Methods;Microglia;migration;mouse model;Mus;Myelogenous;Myeloid Cells;Nature;neoplastic cell;nerve stem cell;Neuropilin-1;normoxia;novel therapeutics;Oncogenic;Operative Surgical Procedures;Output;Oxygen;Pathway interactions;Phenotype;phosphoproteomics;Primary Neoplasm;Process;Property;Quantitative Reverse Transcriptase PCR;Radiation therapy;receptor;recruit;release factor;Reporting;Research;Resistance;response;Role;Shapes;Signal Pathway;Signal Transduction;standard of care;stem cell biomarkers;stem cell growth;stem cell proliferation;stem cells;stemness;Testing;trafficking;Transforming Growth Factor beta;tumor;Tumor Debulking;tumor growth;tumor hypoxia;tumor initiation;tumor microenvironment;tumor-immune system interactions;tumorigenic;Vascular Endothelial Growth Factors;Western Blotting;Work

PROJECT_TITLE: The oncogenic functions of Neuropilin-1 in the glioblastoma tumor microenvironment


PROJECT_TERMS: Advocate;Aging;aging related;Communities;complex data;Data;data resource;Data Set;Demography;Disclosure;Documentation;Educational workshop;Funding;Health;Instruction;interest;Newsletter;Policy Maker;Reporting;Research;Research Personnel;Resources;Source;Specialist;Surveys;Update;Video Recording;web site;Work

PROJECT_TITLE: External Research Resources Support and Dissemination


NIH_SPENDING_CATS: Aging;Clinical Research;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: access restrictions;Aging;Archives;Censuses;Data;data centers;Data Collection;data enclave;Data Set;Demography;design;Environment;Funding;Health;Information Services;Instruction;operation;Outcome;Research;Research Personnel;Resources;Social Sciences;Supervision;technological innovation;Technology;Universities;Wisconsin

PROJECT_TITLE: Remote Data Enclave


ORG_CITY: MINNEAPOLIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Formaldehyde is a naturally occurring metabolite found in all cell types as well as a potent universal toxin. Our work will characterize the first known bacterial mechanisms of formaldehyde homeostasis with a model bacterium that by necessity, has been adapted to navigate formaldehyde stress. This work will provide insights into mechanisms of formaldehyde sensing, formaldehyde-mediated regulation, and mitigation of formaldehyde-induced protein damage.

PI_NAMEs: BAZURTO, JANNELL V. (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TITLE: Formaldehyde homeostasis and damage repair in a bacterial formaldehyde specialist

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it represents a novel approach of using engineered bacteria that can colonize the entire gut and express a desired function. The investigators will use this innovative strategy to engineer microorganisms that help us understand how the gut microbiome affects host physiology. Thus, the proposed research is relevant to the part of NIAID's mission to improving health by the development and acceleration of the basic research, in this case of development of gut microbiome therapies that could impact infectious and immunologic diseases

PI_NAMEs: HASTY, JEFF M;ZARRINPAR, AMIR  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Acceleration;Address;Affect;Antibiotics;Back;Bacteria;Bacteroides;Basic Science;Biological;Chronic Disease;Clinical;combat;Communicable Diseases;Communities;cost;curative treatments;Data;design;Development;Disease;Ecology;Engineering;Engraftment;Environment;Escherichia coli;Functional disorder;Gene Expression;Genetic;Gnotobiotic;Goals;gut microbiome;gut microbiota;Health;host-microbe interactions;Human;Immune System Diseases;improved;in vivo;in vivo Model;Individual;innovation;interest;Intestines;Knock-in;Knowledge;Lactobacillus;Learning;Mediating;metabolomics;microbial community;microbial host;microbiome;microbiome composition;microbiome research;microbiome therapeutics;microorganism;Mission;Modification;Mus;National Institute of Allergy and Infectious Disease;novel strategies;Nutrient;Organism;Outcome;Pathologic;Pathology;patient stratification;Phenotype;Physiological;Physiological Processes;Physiology;prevent;Production;Protein Secretion;Proteins;Public Health;quorum sensing;real world application;Reporting;Research;Research Personnel;risk stratification;Role;Signal Transduction;Source;synthetic biology;System;targeted treatment;technology development;Testing;Therapeutic;tool;tool development;transgene delivery;transgene expression;Transgenes;translational impact

PROJECT_TITLE: Development of Engineered Native Bacteria as a Tool for Functional Manipulation of the Gut Microbiome

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The proposed training program will develop diverse researchers who conduct rigorous, innovative health services research on important challenges facing healthcare in the United States. This research will guide the development of programs, innovations, and policies that strengthen the healthcare system, advance healthcare delivery, and improve the health of Americans.

PI_NAMEs: BAKER, LAURENCE C (contact);OWENS, DOUGLAS K

PROGRAM_OFFICER_NAME: DESOTO, MAUSHAMI

PROJECT_TITLE: Stanford Health Services Research Training Program


ORG_CITY: CHICAGO

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The University of Chicago And Northwestern University Postdoctoral Health Services Research Program, application referred to as the “UCANU Postdoctoral HSR Program,” proposes a multi-institutional, competency-driven postdoctoral training program that will use mentored research, didactics, and professional development activities to train social scientists and clinicians in health services research, implementation science, learning health system methods, health equity and disparities research, systems science, and data science. We aim to develop future leaders whose careers will increase implementation of evidence-based practices, reduce health disparities, and improve health care organization and delivery in the United States.

PI_NAMEs: JORDAN, NEIL  (contact)

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT

PROJECT_TITLE: The University of Chicago and Northwestern University Postdoctoral Health Services Research Program


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD)

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE As ultrasound imaging becomes more ubiquitous and useful in diagnosis and treatment of many diseases, the need increases for improved processing of the data in smaller and lower power systems while not degrading the image quality. This project will explore the cutting-edge techniques in data reduction for ultrasound imaging and their implementation at semiconductor chip level for next generation portable and wearable ultrasound systems.

PI_NAMEs: LI, SHAOLAN  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: analog;Benchmarking;Catheters;Computer software;computerized data processing;cost;Data;Data Collection;Data Compression;data reduction;design;Development;Diagnosis;digital;digital data;Disease;disease diagnosis;elastography;Electronics;energy efficiency;Evaluation;Exhibits;Foundations;Frequencies;Future;Generations;Goals;Image;imaging modality;imaging system;Implant;improved;Individual;integrated circuit;Investigation;Link;Magnetic Resonance Imaging;Measurement;Methods;miniaturized device;Modality;Modeling;multimodality;Nature;next generation;novel;novel strategies;Output;Patient Monitoring;Performance;point of care;portability;Process;programs;prototype;Real-Time Systems;Research;Research Design;Research Methodology;Research Project Grants;Resolution;Sampling;Scheme;Semiconductors;signal processing;Signal Transduction;Speed;System;Systems Integration;Techniques;Testing;theories;Time;tool;Ultrasonography;ultrasound;Validation;wearable device;wireless communication;X-Ray Computed Tomography

PROJECT_TITLE: Space-Time Compressed Sampling Techniques for Integrated Ultrasound Imaging System-on-a-Chip

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Opioids;Serious Mental Illness;Suicide;Violence Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  Borderline personality disorder (BPD) is associated with alarmingly high rates of morbidity and mortality, including suicide attempt (up to 75%), and death by suicide (10%), yet few medications are capable of reducing overall BPD symptom severity or suicide risk. Based on our novel and promising pilot findings, we propose a critical in vivo investigation of a potential pharmacological target for the treatment of symptoms of BPD (including impulsivity, affective lability, and suicidal behavior) - the kappa opioid receptor (KOR). This innovative project will advance understanding of BPD pathophysiology and has the potential to inform treatment development and risk prevention efforts.

PI_NAMEs: DAVIS, MARGARET TAYLOR (contact)

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: abuse liability;Address;Adult;Affect;Affective;Aggressive behavior;Animals;Anti-Anxiety Agents;anti-depressive agents;Area;Attention;Autopsy;beta-Endorphin;Binding;Borderline Personality Disorder;Brain;Brain imaging;Chronic;Chronic stress;Clinical;Clinical Trials;clinically relevant;Data;Depressed mood;Development;Diagnostic;Disease;disorder risk;Dissociation;Distress;Dopamine;Down-Regulation;drug of abuse;Dynorphins;effective therapy;emotion dysregulation;emotion regulation;endogenous opioids;endophenotype;epidemiology study;experience;Functional disorder;Funding;Future;General Population;Goals;high risk;high risk population;Human;Hydrocortisone;imaging study;Imaging Techniques;Impaired cognition;Impulsivity;in vivo;Incidence;Individual;innovation;insight;Insula of Reil;Intervention;Investigation;kappa opioid receptors;Life;Link;Low Prevalence;Magnetic Resonance Imaging;male;men;Molecular;Molecular Target;Morbidity - disease rate;mortality;mu opioid receptors;Neurobiology;novel;Opioid;Opioid Antagonist;opioid mortality;Opioid Peptide;Pain;pain perception;Participant;Peripheral;Pharmaceutical Preparations;pharmacologic;Play;Positron-Emission Tomography;pre-clinical;preclinical study;Prevention;Prognosis;psychiatric symptom;radioligand;radiotracer;receptor expression;receptor-mediated signaling;Recording of previous events;reduce symptoms;reducing suicide;Regulation;Research;Resistance;response;Risk;Risk Reduction;Role;Self-Injurious Behavior;Serotonin;Severities;sex;Sex Differences;social;Social Functioning;Stress;stress related disorder;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide mortality;symptom treatment;symptomatology;Symptoms;System;targeted agent;Techniques;Testing;therapy development;Treatment outcome;treatment risk;Underserved Population;Woman;Work

PROJECT_TITLE: in vivo investigation of KOR as a marker of BPD and suicide related endophenotypes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-B(90)M]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: SURGERY

PHR: Project Narrative: Vocal fold (VF) inflammatory lesions are common voice disorders related to disrupted epithelial homeostasis accompanied by inflammatory infiltrates and changes in the lamina propria. These lesions cause notable changes in voicing thereby impacting the quality of life. In this application, we seek to provide comprehensive characterization of VF Lrig1+ cells as a population of epithelial stem cells that are responsible for hyperplastic epithelial changes associated with disease condition and generate organoids as a reliable culture system to understand VF epithelium health and disease.

PI_NAMEs: LUNGOVA, VLASTA ;THIBEAULT, SUSAN LYNN (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Adult;Affect;Basal Cell;Basement membrane;Benign;Biological Assay;Biological Markers;Biology;Bromodeoxyuridine;capsule;Cell Differentiation process;cell type;Cells;Cellular biology;cytokine;Data;daughter cell;Developmental Biology;Disease;Dyes;economic cost;Ensure;Eosinophilic Esophagitis;Epithelial Cells;epithelial injury;epithelial stem cell;Epithelium;Equilibrium;Exclusion;Functional disorder;Genes;Genetic;Goals;Health;Histologic;Homeostasis;Human;human model;Hyperplasia;Impairment;improved;In Vitro;in vitro Model;in vivo;Inflammatory;Inflammatory Infiltrate;inflammatory milieu;Injury;insight;keratinization;Label;Lamina Propria;Larynx;Lesion;Link;Maintenance;Measures;mechanical load;Mediating;Methods;Modeling;Molecular;Morphogenesis;mouse model;Mucous Membrane;Mus;Natural regeneration;next generation sequencing;notch protein;Organoids;Outcome;Patients;personalized medicine;pharmacologic;Physiological;Polymerase Chain Reaction;Population;postnatal;programs;Proliferating;Property;psychologic;Quality of life;reconstitution;Recovery;Research;response;Role;self-renewal;Signal Transduction;social;stem cell biology;stemness;Stratified Epithelium;Stratified Squamous Epithelium;Stratum Basale;Stress;System;tissue repair;Tissues;transcriptomic profiling;Up-Regulation;vocal cord;Voice;Voice Disorders

PROJECT_TITLE: Understanding Lrig1+ in vocal fold epithelium and organoid biology

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ORG_CITY: Columbus

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Our proposed T32 training program, “ACCELERATE: Accelerating HSR at OSU,” will prepare the next generation of researchers for careers in health services research. ACCELERATE will match experienced mentors with exceptional postdoctoral trainees in a collaborative, multidisciplinary environment at one of the most diverse colleges of medicine in the country. With a foundational emphasis on health equity, our trainees will be equipped to address the most pressing issues in the delivery of healthcare, using data and innovative processes to help people increase their well-being and access to affordable, safe, and effective care throughout their lives.

PI_NAMEs: BURKE, JAMES FRANCIS;JONAS, DANIEL E;MCALEARNEY, ANN SCHECK (contact)

PROJECT_TITLE: ACCELERATE: Accelerating HSR at OSU


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The learning healthcare system is designed to “generate and apply the best evidence to optimize the collaborative healthcare choices of each patient and provider, drive the process of discovery as a natural outgrowth of patient care, and ensure innovation, quality, safety, and value in healthcare.” Vanderbilt is developing investigators in multiple disciplines, who are formally trained and well versed in best methods for engaging and improving the learning healthcare system. We propose to continue training future investigators in the Vanderbilt Patient, pRactice Outcomes and Research in Effectiveness and Systems Science (PROgRESS) Training Program in three distinct methodologic areas: 1) Patient Centered Outcomes Research -To determine which strategies are most effective for patients; 2) Implementation Science-To implement those effective strategies into practice; and, 3) Health Policy/ Community Health-To influence policy to benefit all patients and improve the health of the community.

PI_NAMEs: GRIJALVA, CARLOS G;ROUMIE, CHRISTIANNE L. (contact)

PROJECT_TITLE: Learning Health System training program: PROgRESS-- Patient/ pRactice Outcomes and Research in Effectiveness and Systems Science


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LOWELL

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

ORG_STATE: MA

PHR: NARRATIVE An unsupervised deep learning approach will be developed to enable high-quality photon-counting CT image reconstruction from less data by synergistically combining deep learning, compressive sensing, and iterative reconstruction techniques. It will significantly enhance the imaging performance of photon-counting CT at increased scanning speed, increased spatial resolution, and reduced radiation dose, with initial applications in clinical human extremity imaging.

PI_NAMEs: YU, HENGYONG  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Acceleration;Algorithms;Architecture;Awareness;Back;Big Data;Bismuth;Clinical;clinical application;clinical imaging;Clinical Research;Clinical Trials;cluster computing;computational platform;Computer software;Computer Systems;Contrast Media;Data;data acquisition;Data Compression;Data Set;deep learning;design;detector;Dictionary;Dose;empowerment;Evaluation;experimental study;FDA approved;frontier;Goals;High Performance Computing;Human;Image;Image Enhancement;image reconstruction;imaging modality;improved;Knowledge;Learning;Limb structure;Low Dose Radiation;Maps;Mathematics;Methods;Modeling;Molecular;nanoGold;nanoparticle;Nature;New Zealand;novel;open source;Performance;photon-counting detector;Photons;Planet Mars;Procedures;Protocols documentation;prototype;Publishing;Radiation Dose Unit;Reader;reconstruction;Reporting;Resolution;Roentgen Rays;Scanning;simulation;Software Engineering;Source;spectral energy;Speed;stability testing;System;Techniques;temporal measurement;Testing;theories;Time;Tissues;tomography;Training;Validation;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: Unsupervised Deep Photon-Counting Computed Tomography  Reconstruction for Human Extremity Imaging


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Cardiovascular;Clinical Research;Emerging Infectious Diseases;Heart Disease;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: Boxborough

ORG_NAME: HELIXBIND, INC.

PHR: PROJECT NARRATIVE Infective Endocarditis is a life-threatening disease and a significant economic burden due to prolonged intensive treatment. Early identification of the microbial infection is crucial to improving outcomes, but current standards relying on blood cultures are slow and often yield false-negative results. This prevents the administration of evidence-based antimicrobials precisely when they are maximally beneficial. The efforts described in this Commercialization Readiness Pilot program proposal will advance the maturity of a novel, fully automated test capable of identifying and characterizing these infections directly from patient blood in only a few hours. Success in this effort will result in a critically needed diagnostic, ready for manufacturing scale up as required for FDA trials and market launch.

PI_NAMEs: SINGER, ALON  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acceleration;Address;Affect;analytical method;Antibiotic Resistance;antimicrobial;Antimicrobial Resistance;assay development;Automation;Autopsy;Award;Bacteria;Biological;Biological Assay;Biopsy;Blinded;Blood;Blood Circulation;Breakthrough device;Cardiac;Cardiology;Caring;Clinic;Clinical;Clinical assessments;Clinical Microbiology;Clinical Research;commercialization;commercialization readiness;Communicable Diseases;Coxiella burnetii;Death Rate;design;Development;Diagnosis;Diagnostic;diagnostic strategy;Disease;Disease Progression;Early identification;Economic Burden;Endocarditis;Engineering;Ensure;Evaluation;evidence base;Exhibits;experience;Feedback;Freeze Drying;fungus;Grant;Heart;Hospitalization;Hospitals;Hour;Impairment;improved;improved outcome;Infection;Infective endocarditis;instrument;interest;Intervention;Leadership;Lesion;Life;Manuals;manufacture;manufacturing process;manufacturing scale-up;Marketing;Medical center;member;Methods;microbial;microorganism;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;Nature;novel;novel diagnostics;Organism;pathogen;pathogenic bacteria;pathogenic fungus;Patient Care;Patient-Focused Outcomes;Patients;Performance;Phase;prevent;programs;Quality of life;Readiness;Reagent;Resistance;Resistance development;Resolution;Risk;Sampling;Sensitivity and Specificity;Sepsis;Septicemia;Site;Small Business Innovation Research Grant;Specific qualifier value;Specificity;Specimen;standard of care;success;Surface;Symptoms;Technology;Temperature;Testing;Time;Tissues;University Hospitals;validation studies;verification and validation;Whole Blood

PROJECT_TITLE: Commercialization Readiness Pilot (CRP) program support for: Direct-from-specimen identification of pathogens common in endocarditis


NIH_SPENDING_CATS: Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: VALHALLA

ORG_NAME: NEW YORK MEDICAL COLLEGE

ORG_STATE: NY

PHR: Narrative Human iPSCs can provide unlimited sources of human neurons to study disease mechanisms; but in vitro neuronal cultures lack many important brain components that play crucial roles in neuronal functions. Thus, we will generate brain-region-specific humanized cortical interneuron mice to allow for the study of the role of grafted human neurons in brain circuit and behavioral functions. Such physiological humanized models will facilitate the understanding of cell-type-specific and brain-region-specific disease mechanisms, and the development of novel therapeutics.

PI_NAMEs: CHUNG, SANGMI  (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Ablation;Address;Area;Astrocytes;autism spectrum disorder;Behavior;Behavioral;Behavioral Assay;Biological Models;Blood Vessels;Brain;Brain Diseases;Brain region;Cell Culture Techniques;cell type;Central Nervous System;Chimera organism;cognitive function;cognitive task;cognitive testing;Complex;Data;Development;Disease;disease mechanisms study;Dorsal;Dose;Electrodes;Electrophysiology (science);Environment;experimental study;Failure;Future;Genetic;Graft Survival;Hippocampus;Histologic;Human;human disease;human fetal brain tissue;human induced pluripotent stem cells;Immunohistochemistry;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;Injections;Interneuron function;Interneurons;Medial;Methods;Microglia;Modeling;Mus;Neurons;neuropsychiatric disorder;novel;novel therapeutics;Oligodendroglia;optogenetics;Pathogenesis;Patients;Phenotype;physiologic model;Physiological;Play;Pluripotent Stem Cells;Population;Prefrontal Cortex;Qualifying;Regulation;restoration;risk variant;Rodent;Rodent Model;Role;Schizophrenia;Slice;Source;stem cells;Synapses;System;Testing;Therapeutic;Titrations;Transplantation;Untranslated RNA;Viral Vector

PROJECT_TITLE: Brain-region-specific humanized cortical interneuron mice

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE The goal of this project is to investigate if immune profiles in breast tumors from American women of African ancestry (AA) differ from those in women of European ancestry (EA), are associated with differentially distributed risk factors, and to more aggressive tumors as well as to survival. Results from this study may have important implications for clinical studies of immunotherapy with application to AA women, particularly those with more aggressive tumors.

PI_NAMEs: ABRAMS, SCOTT I.;AMBROSONE, CHRISTINE B. (contact);YAO, SONG

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TERMS: adaptive immunity;Address;Africa;African;African American Women;African ancestry;African Women;aggressive breast cancer;Anti-Inflammatory Agents;Antibodies;Biological Assay;Biology;breast cancer survival;cancer health disparity;cancer immunotherapy;Cancer Patient;cancer therapy;candidate marker;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Characteristics;Chronic;clinical investigation;Clinical Research;Communicable Diseases;comorbidity;Complement;cytokine;cytotoxic;Data Set;Dietary Practices;differential expression;Enrollment;Ensure;Epidemiologic Factors;epidemiology study;Equilibrium;Estrogen receptor negative;Estrogen receptor positive;Estrogen Receptor Status;Etiology;European ancestry;exhaust;exhaustion;Flow Cytometry;Gene Expression;Gene Expression Profile;Gene Frequency;Genes;Genetic;genomic locus;Goals;Health;Immune;immune resistance;Immune response;Immune System Diseases;Immunity;Immunofluorescence Immunologic;Immunogenomics;Immunologic Markers;immunoregulation;Immunotherapy;In Vitro;Incidence;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;Infrastructure;insight;liquid crystal polymer;Macrophage;Malaria;Malignant Breast Neoplasm;malignant phenotype;Mammary Neoplasms;Maps;Methods;modifiable risk;Molecular;monocyte;mortality;mRNA Expression;multidisciplinary;Natural Immunity;Nature;neoplastic cell;non-genetic;Obesity;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;peripheral blood;Pharmaceutical Preparations;Phenotype;Physical activity;Pilot Projects;Plasma;Population;Prognosis;Prognostic Factor;Proliferating;Property;Race;racial difference;recruit;Refractory;reproductive;Research;Risk;Risk Factors;Role;Shapes;social factors;Survival Analysis;T-Lymphocyte;Testing;transcriptome;transcriptomic profiling;tumor;tumor microenvironment;Tumor Subtype;Tumor Tissue;Tumor-Infiltrating Lymphocytes;Validation;Variant;Woman;Women's study

PROJECT_TITLE: Tumor Immune Contexture and Breast Cancer Disparities: A Multi-Disciplinary Study in Women of African and European Ancestry


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

PHR: PROJECT NARRATIVE The research goal of this proposal is to understand the neurobiological mechanisms of three features of fatigue (feeling of weariness, sense of effort, and willingness to exert effort) in healthy individuals and individuals with post-acute sequelae of SARS-CoV-2 infection (PASC). These studies will significantly advance our understanding of fatigue, one of the most common and debilitating symptoms in the health care system, and contribute to the NIH's RECOVER initiative, which seeks to understand, treat, and prevent PASC. In addition, the proposed training plan will allow me to acquire expertise in neuroimaging, psychophysiology, and computational and translational neuroscience for an independent research career that will aim to understand how fatigue manifests in PASC and other illnesses.

PI_NAMEs: CASAMENTO MORAN, AGOSTINA  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: acute COVID-19;Affect;Affective;Age;Behavioral;Biofeedback;Biomedical Engineering;Brain;career;career development;Chronic Disease;Clinical;common symptom;computational neuroscience;Computing Methodologies;COVID-19;Data;debilitating symptom;Decision Making;Development Plans;Dimensions;Economic Burden;Epidemiology;Exhibits;experimental study;Faculty;Fatigue;Feeling;Foundations;Future;Goals;Health;Healthcare Systems;Individual;Intervention;Isometric Exercise;Laboratories;Learning;Magnetic Resonance Imaging;Measures;Mentors;Methods;motor control;Muscle;Nature;neural correlate;neurobiological mechanism;neuroeconomics;neuroimaging;Neurologic;neuromuscular;novel;Participant;Patient Self-Report;Phase;Physiology;Positioning Attribute;Post-Acute Sequelae of SARS-CoV-2 Infection;prevent;Psychophysiology;Race;Research;Research Personnel;response;SARS-CoV-2 infection;Secure;sex;skill acquisition;skills;Symptoms;Syndrome;Techniques;Training;translational neuroscience;United States;United States National Institutes of Health;willingness

PROJECT_TITLE: Neurobiological Mechanisms of Fatigue in Health and after COVID-19


ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative  All neurons are remarkably different and existing approaches do not allow visualization of living cells in intact brains without making transgenic animals. Here, the multidisciplinary team will develop and validate novel technology for neuronal selection (Neuro-SELEX) to label specific neurons within highly heterogeneous cell populations and characterize membrane molecules associated with unique neuronal phenotypes. As a result, this research will generate advanced nanoprobes for single-cell deciphering of neural circuits and single-cell biomarker discovery in neuropathologies and diagnostics.

PI_NAMEs: MOROZ, LEONID L (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Ablation;analog;Animals;Antibodies;Aplysia;aptamer;Axon;Bar Codes;base;Benzene;Binding;biomarker discovery;Brain;cell type;Cells;Chemical Evolution;Chemicals;cholinergic;Complex;cost efficient;Data;design;Diagnostic;Disease;DNA;Electroporation;Etiology;Evolution;Experimental Designs;Experimental Models;experimental study;fabrication;Fine needle aspiration biopsy;Flare;Fluorescent Probes;fluorophore;Genome;Genomics;Glutamates;Heterogeneity;Hybrids;In Situ Hybridization;In Vitro;in vivo;Infrastructure;Injections;Interneurons;Knowledge;Label;Libraries;Ligands;Maps;Mass Spectrum Analysis;Membrane;Membrane Proteins;Memory;Micelles;Modeling;Molecular;molecular manufacturing;Molecular Probes;Molecular Target;Motor Neurons;multidisciplinary;nano;nanoprobe;nanoscale;nanotool;Nervous System;neural;neural circuit;Neuroglia;Neurologic;neuron development;Neurons;neuropathology;new technology;Nociceptors;novel;nucleic acid analog;Nucleic Acids;nucleobase;optogenetics;Organ;personalized medicine;Phenotype;Population;postsynaptic;postsynaptic neurons;presynaptic;presynaptic neurons;Process;Proteomics;Publishing;receptor;Reporter;Research;single-cell RNA sequencing;Synapses;System;Technology;technology development;Testing;Time;tool;Transgenic Animals;Viral;virtual;Visualization

PROJECT_TITLE: Neuron-SELEX: Development of neuron-specific nanoscale toolkits for single-cell recognition

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Hematology;Immunotherapy;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Hemophilia A is an inherited bleeding disorder caused by the lack of coagulation factor VIII (FVIII) and resulting in debilitating joint disease due to chronic bleeding. The immune response to replacement FVIII therapy is a significant concern that could be alleviated by better characterization of the factors that predispose to or regulate anti-FVIII antibody development. This proposal seeks to understand the pathogenesis of FVIII antibodies and investigates the mechanism of a potential novel regulator, B cell activating factor (BAFF), in FVIII immunogenicity with the goal of developing targeted therapies.

PI_NAMEs: DOSHI, BHAVYA SHARAD (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Advisory Committees;Affinity;Animal Model;anti-CD20;Antibodies;Antibody Response;Antibody Therapy;Antigens;arthropathies;Autoimmune Diseases;Award;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Basic Science;belimumab;Beta Cell;biobank;Biological Markers;Blood;Blood Coagulation Disorders;Bypass;career;Career Choice;career development;CD4 Positive T Lymphocytes;Cell Maturation;Cells;Cementation;Chronic;Clinic;Coagulation Factor Deficiency;Coagulation Process;cytokine;Cytokine Gene;Data;Dendritic Cells;Dependence;Development;Disease;Dose;Educational workshop;enzyme replacement therapy;Equilibrium;experience;F8 gene;Factor VIII;Fibroblasts;Fostering;Functional disorder;Future;Generations;Genetic;Genetic Polymorphism;Genomics;Genotype;Goals;hands on research;Helper-Inducer T-Lymphocyte;Hematological Disease;Hematopoietic;Hemophilia A;Hemorrhage;Hemostatic function;Homeostasis;Human;Immune;Immune response;Immune Tolerance;Immunization;Immunize;immunogenicity;Immunoglobulin Somatic Hypermutation;Immunologics;Immunology;immunomodulatory strategy;immunomodulatory therapies;improved;In Vitro;in vivo;Infusion procedures;Inherited;inhibitor;inhibitor therapy;insight;Interleukin-10;Investigation;Isoantibodies;Joints;Kinetics;Learning;Licensing;Location;Marrow;Mature B-Lymphocyte;member;Memory;Memory B-Lymphocyte;Mentors;Methods;migration;Morbidity - disease rate;mortality;mouse model;MS4A1 gene;Mus;Mutation;neutralizing antibody;novel;novel marker;Pathogenesis;Patients;Persons;Pharmaceutical Preparations;Phenotype;Physicians;Plasma Cells;Population;pre-clinical;predictive marker;Predisposing Factor;prevent;Prevention strategy;Proliferating;Quality of life;recruit;Research;Research Proposals;response;Role;Sampling;Science;Scientist;secondary lymphoid organ;Secondary to;Series;skills;Source;Structure of germinal center of lymph node;Susceptibility Gene;T cell response;T-Lymphocyte;targeted treatment;Therapeutic;tissue culture;TNF gene;Training;Training Programs;Translating;translational physician;Translational Research;treatment strategy;Variant;Work

PROJECT_TITLE: Mechanistic insights into factor VIII inhibitor formation and eradication


NIH_SPENDING_CATS: Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Genetics;Heart Disease;Muscular Dystrophy;Pediatric;Pediatric Cardiomyopathy;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE Patients with Duchenne muscular dystrophy (DMD) primarily die from heart failure, and any therapies that could prevent or treat this cardiomyopathy could extend their lives significantly. Our preliminary studies suggest that thromboxane/prostanoid receptor activation helps drive DMD cardiomyopathy, and our goals here are to determine the role this receptor plays in DMD fibrosis and heart failure, to investigate effects of antagonism or deletion of the thromboxane/prostanoid receptor when combined with standard-of-care therapeutics, and to compare the molecular and clinical response to thromboxane/prostanoid receptor antagonism in DMD patients. Completion of this project could improve the chance of clinical success for a cardiac-specific muscular dystrophy treatment, and would help us understand how heart failure develops in DMD.

PI_NAMEs: WEST, JAMES D (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Address;Affect;Angiotensin-Converting Enzyme Inhibitors;Angiotensins;antagonist;Arrhythmia;Binding Proteins;Biological Markers;biomarker identification;boys;Calcium;Cardiac;Cardiac Myocytes;Cardiac Output;Cardiomyopathies;Cause of Death;Cell Membrane Permeability;Cells;Cessation of life;Clinical;Clinical Research;Clinical Trials;Complex;coronary fibrosis;Coupled;Data;Deterioration;Diffuse;Dilated Cardiomyopathy;Dose;drinking water;driving force;Duchenne cardiomyopathy;Duchenne muscular dystrophy;Dystrophin;Enrollment;Expression Profiling;Fibroblasts;Fibrosis;Generations;Genes;Genetic Polymorphism;Goals;GTP-Binding Proteins;Heart;Heart failure;heart function;heart preservation;Human;ifetroban;Immune;improved;Individual;induced pluripotent stem cell derived cardiomyocytes;inhibitor;Isoproterenol;Knockout Mice;Knowledge;Life;Limb-Girdle Muscular Dystrophies;Magnetic Resonance;male;mdx mouse;Mediating;Membrane;Messenger RNA;Modeling;Molecular;mouse model;Mus;Muscle Cells;Muscular Atrophy;Muscular Dystrophies;Muscular dystrophy cardiomyopathy;muscular dystrophy mouse model;Mutation;Myocardial dysfunction;Necrosis;Newborn Infant;Oral;Outcome;Participant;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phase II Clinical Trials;Phenotype;Physiologic intraventricular pressure;Play;Predisposition;Prednisone;premature;prevent;Prevention;Prostaglandins;Proteins;receptor;Receptor Activation;recruit;Regulation;Renin;Research;response;Role;Signal Transduction;Smooth Muscle;standard of care;Stress;success;Surrogate Endpoint;Telomere Shortening;Testing;Therapeutic;Thromboxane Receptor;Thromboxanes;transcriptomic profiling;Transforming Growth Factor beta;Transforming Growth Factors;treatment group;treatment response;Utrophin;Water;Weaning

PROJECT_TITLE: Activity and therapeutic antagonism of the TP receptor in cardiomyopathy of muscular dystrophy

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Cancer;Genetics

PHR: Project Narrative Signal transduction in development and disease PI: Rohatgi The Hedgehog and WNT pathways are two of the central systems for cell-cell communication, controlling both the formation and the maintenance of most tissues in our bodies. We are working to understand how these systems receive signals from outside the cell to eventually change the activation of genes in the nucleus. Our results will influence strategies to monitor and repair this pathway in developmental disorders, degenerative conditions and cancers.

PI_NAMEs: ROHATGI, RAJAT  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Academia;Adult;Age Years;Area;Award;beta catenin;Biochemical;Biological;Cell Communication;Cell membrane;Cell Nucleus;Cell surface;Cells;Cessation of life;Cholesterol;Cilia;ciliopathy;Collaborations;Colorectal Cancer;Communication;Complex;Congenital Abnormality;CRISPR/Cas technology;Cytoplasm;Defect;Degenerative Disorder;Development;developmental disease;Disease;Drug resistance;Erinaceidae;Family;Fellowship;Funding;Gene Activation;Genetic;Genetic Screening;Genetic Transcription;Glioblastoma;Goals;Human;human disease;Industry;Investigation;Laboratories;Life;Ligands;Lipid Biochemistry;Maintenance;Malignant Neoplasms;Membrane;Microscopy;Monitor;Mutation;National Institute of General Medical Sciences;Oncogenic;Organelles;Pathway interactions;Persons;Pharmaceutical Preparations;Physiological;Positioning Attribute;programs;Proteins;Publications;receptor;repaired;Research;Research Support;resistance mechanism;Second Messenger Systems;Signal Transduction;structural biology;Surface;Syndrome;System;Techniques;Therapeutic Index;Tissues;transcription factor;transmission process;WNT Signaling Pathway;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative Circadian rhythms are used by organisms to align physiology and behavior with the 24-hr day/night cycle generated by our earth’s rotation. The goal of this project is to develop an understanding of the cellular mechanisms by which microbial signals integrate into vertebrate circadian rhythms. Circadian rhythms have been found in all domains of life, where they help organisms anticipate environmental change and optimize physiology to promote health.

PI_NAMEs: KIMMEY, JACQUELINE MISUM (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Affect;Animals;ARNTL gene;Behavior;Cells;circadian;circadian pacemaker;Circadian Rhythms;cold blooded vertebrate;Complex;cryptochrome;Cues;Drosophila genus;Environment;environmental change;Feedback;Genetic;Genetic Transcription;Genome;Goals;Health Promotion;Hour;Immune;in vivo;Invertebrates;Kinetics;Life;Mammals;Microbe;microbial;migratory population;Molecular;molecular clock;mouse model;Mus;non-invasive imaging;novel;Organism;Physiology;Planet Earth;Regulation;Research;response;Rotation;Signal Transduction;System;Time;Transcriptional Activation;Translations;Zebrafish

PROJECT_TITLE: Microbial regulation of vertebrate circadian clocks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: AMES

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Project Narrative Malaria control and eradication efforts are hindered by resistance to frontline anti-malarial drugs and new therapeutic options that target novel parasite biology are urgently needed. Host cell remodeling by exported effector proteins is central to parasite survival and Malaria disease and the PTEX translocon that drives this process has emerged as an important new drug target. This project will determine the mechanism of PTEX cargo selection and regulation as well as its function across vertebrate infection to reveal how PTEX and other export pathway components can be targeted for development of novel anti-malarials.

PI_NAMEs: BECK, JOSH RYAN (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Anti-malarials;Biology;Blood;Cells;combat;Complex;conditional mutant;crosslink;Cryoelectron Microscopy;Curiosities;Data;Development;Disease;Drug resistance;Erythrocytes;Event;fitness;Hepatocyte;Host Defense;in vivo;Infection;intrahepatic;knock-down;Label;Licensing;Life Style;Link;Liver;liver infection;Malaria;Mediating;Membrane;Membrane Proteins;Methods;Modeling;Molecular Chaperones;Mutagenesis;N-terminal;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Nutrient;obligate intracellular parasite;Parasites;Parasitic Diseases;pathogen;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Permeability;plasmepsin;Plasmodium;Process;protein complex;Protein Export Pathway;protein function;Proteins;Public Health;Regulation;Resistance;Role;Secure;Site;Structure;System;Testing;Time;Transmembrane Transport;unfoldase;unnatural amino acids;Vacuole

PROJECT_TITLE: PTEX mechanism in malaria parasite effector protein export and host cell subversion

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]