NIH_SPENDING_CATS: Bioengineering

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The Stanford-SLAC CryoET Specimen Preparation Service Center (SCSC) was established to meet the emerging national need for cryoET as a structural biology tool. The Center facility will enable external users to streamline the preparation of samples through providing access to, and support for, advanced cryo-specimen preparation techniques (cryoFLM, cryoFIB, and cryoEM/ET) for a wide range of samples with biomedical applications, in addition to providing training of the technologies to new users. This supplement is requested to meet unanticipated needs for the transfer of grids with vitrified cellular samples to and from Aquilos 2 cryogenic focused ion beam scanning electron microscope to perform the milling to thin the thick cells to the proper thickness with minimum amount ice contamination.

PI_NAMEs: CHIU, WAH  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Academia;Adopted;Advisory Committees;Area;Award;Biocompatible Materials;Biological;Cells;Collaborations;Communication;Communities;Complex;Cryo-electron tomography;Cryoelectron Microscopy;cryogenics;Data Collection;data management;Dedications;Educational Curriculum;Educational workshop;Electron Microscope;electron tomography;Equipment;Evaluation;experience;experimental study;Fluorescence Microscopy;Freezing;Funding;Goals;Grant;Hydration status;Ice;imaging modality;In Situ;Industry;Infrastructure;innovative technologies;Institution;instrument;instrumentation;Ions;Laboratories;Lifting;Macromolecular Complexes;Methods;Microscope;nanometer resolution;operation;Organelles;Preparation;Process;Professional Organizations;Protocols documentation;Recurrence;Request for Applications;Research;Resource Allocation;Resources;response;Sampling;Scanning;Scanning Electron Microscopy;Schedule;Selection Criteria;Services;Specialized Center;Specimen;structural biology;Subcellular structure;symposium;Techniques;Technology;Thick;Thinness;Tissue Sample;Tissues;Titan;tool;Training;Training Activity;United States National Institutes of Health;web portal;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(51)-R]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: IRVINE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on understanding neural network mecha- nisms underlying long-term memory impairment in epilepsy and testing closed-loop strategies for ameliorating this impairment. Such strategies offer the potential for a significant advance in addressing cognitive comorbidity in patients with epilepsy, in line with the NINDS mission to use mechanistic knowledge to reduce burden of neurological disease.

PI_NAMEs: GELINAS, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Address;Affect;Animal Model;Area;Behavioral;Biological Assay;Brain;Brain region;Cognitive;Communication;comorbidity;Confocal Microscopy;Coupling;Data;Development;Electric Stimulation;Electrophysiology (science);Epilepsy;Evaluation;Foundations;Gene Expression;Goals;Hippocampus;Immediate-Early Genes;Immunohistochemistry;Impaired cognition;Impairment;improved;in vivo;Information Storage;innovation;Knowledge;Link;long term memory;Medial;medial temporal lobe;Memory;memory consolidation;Memory impairment;Mission;Modeling;Molecular;molecular marker;molecular scale;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;network dysfunction;neural;neural network;neural patterning;Neurons;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;Output;Pathologic;Patients;Pattern;Physiological;Play;Population;Prefrontal Cortex;prevent;Prevention;programs;Protocols documentation;Public Health;Rattus;Research;response;restoration;Risk Factors;Rodent;sleep spindle;spatial memory;spatiotemporal;Structure;Synaptic plasticity;targeted treatment;Temporal Lobe Epilepsy;Testing

PROJECT_TITLE: Closed-Loop Modulation of Hippocampal-Cortical Communication in Temporal Lobe Epilepsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LEXINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: NARRATIVE The overarching goal of the University of Kentucky (UK) SuRE Resource Center is to build research capacity at SuRE-eligible institutions, recognizing the vital contribution these colleges and universities make to the nation's research enterprise. Through a series of webinars and other training modalities, direct consultation, a competitive seed grant program to create or enhance offices of sponsor projects (OSPs), and biennial conferences, experienced UK faculty and research support staff will assist faculty and OSP staff at SuRE- eligible institutions prepare and submit competitive NIH grants applications, with an emphasis on SuRE and SuRE-First awards. Multiple methods will be used to collect and analyze data to measure the success of this center.

PI_NAMEs: MURPHY, MICHAEL PAUL;SPEAR, BRETT T (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Applications Grants;Area;Authorship;Award;Biomedical Research;career;college;Communication;Communities;Consultations;Data;Educational workshop;Eligibility Determination;Employment;Ensure;expectation;experience;Face;Faculty;faculty mentor;faculty support;Feedback;First Independent Research Support and Transition Awards;Fostering;Funding;Goals;Grant;Growth;human disease;Individual;Infrastructure;Institution;Kentucky;Knowledge;Link;Marketing;Measures;meetings;Mentors;Methods;Minority-Serving Institution;Modality;National Institute of General Medical Sciences;next generation;Outcome;peer;Population;Preparation;Process;programs;Publications;Questionnaires;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Schools;Science;Series;Services;Site;skills;social media;student conference;student mentoring;Students;success;symposium;Training;United States;United States National Institutes of Health;Universities;webinar;Writing

PROJECT_TITLE: University of Kentucky SuRE Resource Center


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Lung;Ovarian Cancer;Rare Diseases;Urologic Diseases;Women's Health Research

ORG_CITY: CALVERTON

ORG_NAME: INFORMATION MANAGEMENT SERVICES, INC.

ORG_STATE: MD

PI_NAMEs: RILEY, THOMAS  (contact)

PROJECT_TERMS: Area;biobank;Biocompatible Materials;Biological;Cancer Etiology;Colorectal;Colorectal Cancer;Contracts;Data;data access system;early detection biomarkers;Etiology;improved;Internet;Logistics;Lung;Malignant neoplasm of lung;Malignant neoplasm of ovary;Monitor;Ovarian;Participant;Peer Review;Process;programs;Prostate;Qualifying;Research Personnel;Research Project Grants;Resources;Risk Factors;Sampling;screening;Services;Specimen;System;Tissue Sample;Tissues;Update

PROJECT_TITLE: PROSTATE LUNG COLORECTAL OVARIAN (PLCO) ETIOLOGIC AND EARLY MARKER STUDIES (EEMS)


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Genetics;Human Genome;Nutrition;Pediatric;Prevention

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PI_NAMEs: TSAI, MICHAEL  (contact)

PROJECT_TERMS: Adipose tissue;Adolescent;adolescent health;Adult;Antioxidants;Behavior;Biocompatible Materials;Biological;Biological Assay;Biological Markers;Blood;C-reactive protein;Caring;Carotenoids;Child Development;Child Health;Clinical;Clip;Collection;Concentration measurement;Conceptions;Consultations;Contractor;Contracts;cytokine;Data;design;Development;dietary;DNA;Enzyme-Linked Immunosorbent Assay;epidemiology study;Etiology;exome sequencing;Fatty Acids;flexibility;Follicular Fluid;Gene Chips;genome wide association study;Glucose;Growth and Development function;Hair;Health;Heavy Metals;Hormones;Human;immune function;Immune system;Infant;innovation;Intervention Studies;Laboratories;Leptin;leptin receptor;life span;Measurement;Measures;Metabolic;metabolomics;Methylation;microbiome analysis;Nail plate;National Institute of Child Health and Human Development;Newborn Infant;Nutritional;Observational Study;Omentum;Personal Satisfaction;Placenta;Plasma;population health;Pregnant Women;Principal Investigator;Proteomics;Protocols documentation;repository;Reproduction;reproductive;Research;Research Activity;Research Design;Research Project Grants;research study;RNA;Saliva;sample collection;Scientist;Seminal fluid;Serum;Services;Specimen;Spottings;steroid hormone;Study Subject;Techniques;Testing;Tissues;Tocopherols;Triglycerides;Umbilical Cord Blood;Urine;Whole Blood

PROJECT_TITLE: BIOMEDICAL ASSAY LABORATORY FOR THE DIVISION OF POPULATION HEALTH RESEARCH - PROJECT TRACKING AND CONSULTATION


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Social Determinants of Health

ORG_CITY: SILVER SPRING

ORG_NAME: SOCIAL AND SCIENTIFIC SYSTEMS,  INC.

PI_NAMEs: GLOVER, JAMIE  (contact)

PROJECT_TERMS: Address;Affect;Age;Agriculture;Air Pollution;Alcohol consumption;analytical method;Asthma;Back;Biological Assay;Callback;Canada;Chemical Exposure;Childhood;Clinical Data;Clinical Research;cohort;Cohort Studies;Collection;Complex;Computerized Medical Record;Data;Data Collection;demographics;Denmark;Diabetes Mellitus;Diet;Disease;disorder risk;Disparity population;Education;Electronic Health Record;electronic medical record system;Environment;Environmental Exposure;Environmental Risk Factor;Ethnic Origin;Etiology;Exposure to;Family history of;Follow-Up Studies;gene environment interaction;Genes;Genetic;Genetic Polymorphism;Genetic study;genetic variant;genome sequencing;Genotype;Geographic Information Systems;Goals;Health;health disparity;Heart Diseases;HLA Antigens;Home;Human;Hypersensitivity;improved;interest;International;International Classification of Diseases;Japan;Length;Life;Life Style;lifestyle factors;Link;Malignant Neoplasms;Medical;multidimensional data;Multiomic Data;Multiple Sclerosis;National Institute of Environmental Health Sciences;North Carolina;novel;Occupational Exposure;operation;Participant;participant enrollment;Persons;Pharmaceutical Preparations;Phenotype;Physical activity;Population;Psoriasis;Race;Recording of previous events;Registries;Research;Research Personnel;Resolution;response;Rheumatoid Arthritis;Risk;Risk Factors;Scientist;Single Nucleotide Polymorphism;Site;Sleep;Smoking;Socioeconomic Status;Stress;Stroke;Surveys;telomere;United States;United States National Institutes of Health;Universities;Validation;Variant;whole genome;Work

PROJECT_TITLE: TASK ORDER 5R - PERSONALIZED ENVIRONMENT AND GENES STUDY (PEGS)


ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PI_NAMEs: SWERDLOFF, RON  (contact)

PROJECT_TERMS: Clinical Trials Network;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;Future;Goals;Male Contraceptive Agents;men;Mission;National Institute of Child Health and Human Development;product development;protocol development;Protocols documentation;Site;Woman

PROJECT_TITLE: CCTN-CORE FUNCTION ACTIVITIES - SITE OF MALE CONTRACEPTIVE STUDIES - UCLA-LUNDQUIST


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: A substantial majority of Veterans with posttraumatic stress disorder (PTSD) continue to suffer even with the best current medications. New scientific tools are urgently needed to overcome poor understanding of the links between symptoms, brain dysfunction, and the specific effects of medications to develop better and more targeted PTSD treatments. Preliminary research has shown that the stimulant methylphenidate caused robust reduction in PTSD symptoms, but the mechanism of this effect is unknown. This project aims to apply new computational and neuroimaging methods to characterize the mechanism by which methylphenidate improves PTSD in Veterans. It will use these tools to quantitatively measure the effect of methylphenidate in enabling the brain to more flexibly adapt to different environments, thereby reducing the brain’s hyper-reactivity to sensory stimulation. The ultimate goal is to enable individualized treatments for Veterans with PTSD and the development of new, more effective medications for this burdensome disorder.

PI_NAMEs: HOWLETT, JONATHON R (contact)

PROJECT_TERMS: Acute;Address;anxiety states;anxious individuals;Arousal;associated symptom;Attention deficit hyperactivity disorder;Behavior;Behavior assessment;Behavioral;Brain;brain dysfunction;Brain region;career;Clinical;combat veteran;Complex;Computer Analysis;Computer Models;Cues;Data;Development;Dimensions;Disabling condition;Disease;Disparate;Dopamine;Dopamine Uptake Inhibitors;Dose;Double-Blind Method;effective therapy;Environment;Exhibits;experience;Failure;flexibility;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Impairment;improved;Individual;individualized medicine;Intervention;Learning;Link;Measurable;Measures;Mental Health;Mentors;Methods;Modeling;Molecular;neural;neural circuit;neuroimaging;Norepinephrine;novel;optimal treatments;Parietal Lobe;Patient Selection;personalized intervention;personalized medicine;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Placebos;Post-Traumatic Stress Disorders;Prediction of Response to Therapy;Process;Psychiatry;psychopharmacologic;Psychopharmacology;Randomized;randomized, controlled study;Randomized, Controlled Trials;rate of change;Regulation;Research;response;Ritalin;Sampling;Scientist;Sensory;Services;Specific qualifier value;stem;Stimulant;symptom cluster;Symptoms;Testing;tool;Translating;translational approach;Treatment outcome;Veterans

PROJECT_TITLE: Computational Analysis of Neural Effects of Methylphenidate in Posttraumatic Stress Disorder


ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: Post-traumatic stress disorder (PTSD) is a debilitating and highly prevalent disorder in both the Veteran and general population. One under-studied, but highly significant consequence of PTSD is a significantly increased risk of developing hypertension and cardiovascular disease. The overarching goal of this research program is to elucidate the mechanistic roles of sympathetic nervous system (SNS) dysregulation in future cardiovascular risk in post-9/11 Veterans with PTSD. Specifically, this project will determine the downstream effects of heightened SNS reactivity on renal vasoconstriction and neurovascular transduction mediated by vascular alpha-1 adrenergic receptor sensitivity using state-of-the-art human physiology techniques. We will also assess the potential therapeutic role of transcutaneous vagus nerve stimulation in ameliorating SNS overactivation and improving arterial baroreflex sensitivity in PTSD. Given the large numbers of post-9/11 afflicted with PTSD, understanding the mechanisms of SNS overactivity in PTSD is crucial for impacting future cardiovascular risk.

PI_NAMEs: PARK, JEANIE  (contact)

PROJECT_TERMS: absorption;Acute;Address;Adrenergic Agents;Adrenergic Receptor;afferent nerve;Afghanistan;Agonist;alpha-1 adrenergic receptors;Anti-Inflammatory Agents;Baroreflex;Biological Markers;Blood Flow Velocity;Blood Pressure;blood pressure elevation;blood pressure regulation;Blood Vessels;Brain Stem;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cervical;cholinergic;Chronic Disease;Data;Development;Devices;Disease;Doppler Ultrasound;Dose;Efferent Neurons;Electric Stimulation;Electrocardiogram;experimental study;Future;General Population;Goals;Health;hemodynamics;high risk population;Human;Hypertension;Impairment;improved;Inflammation;Inflammatory;insight;Intervention;Iraq;Kidney;kidney vascular structure;Measures;Mediating;Mental disorders;military veteran;Muscle;Nerve;Nerve Fibers;Nervous System Physiology;neurovascular;Nonpharmacologic Therapy;novel;Nucleus solitarius;Organ;Output;Parasympathetic Nervous System;Pathogenesis;Pathway interactions;patient population;Patients;peripheral blood;Peripheral Resistance;pharmacologic;Phenylephrine;Physiology;Plasma;post 9/11;Post-Traumatic Stress Disorders;prevent;programs;Psyche structure;receptor sensitivity;Regulation;Renal Blood Flow;Renin;Renin-Angiotensin System;Research;response;Rest;Risk;Risk Factors;Role;Sodium;Stress;Sympathetic Nervous System;Techniques;Testing;Therapeutic;therapeutic target;Time;vagus nerve stimulation;Vagus nerve structure;vascular abnormality;Vascular resistance;vasoconstriction;Veterans;Work;young man;young woman

PROJECT_TITLE: Mechanisms of Sympathetic Overactivity in Post-traumatic Stress Disorder


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Long-term use of a class of medications known as benzodiazepines raises risk of cognitive problems, falls, addiction, and overdose. One method of helping patients who have been on these medications for extended periods is to provide them with information regarding how to taper off. This study develops such a self-tapering tool for use as a smart phone app and tests whether it works in a sample of 170 Veterans and how much it would cost to make the tool widely accessible.

PI_NAMEs: CUCCIARE, MICHAEL ANTHONY;HUMPHREYS, KEITH N. (contact)

PROJECT_TERMS: Academic Detailing;Accidents;addiction;Anxiety;anxiety symptoms;Benzodiazepines;Brain Injuries;budget impact;Caring;Cellular Phone;Clinical;Clinical Trials;Cognitive;Computers;Conduct Clinical Trials;connected care;cost;cost estimate;Databases;Dependence;design;Development;Dose;Education;Effectiveness;effectiveness clinical trial;Electronics;Event;experience;falls;field study;Focus Groups;follow-up;functional outcomes;Future;Goals;Health;Healthcare promotion;Impaired cognition;improved;innovation;interest;Intervention;intervention cost;medication safety;Methodology;Methods;military veteran;Opioid;Overdose;Paper;Patients;Pharmaceutical Preparations;pharmacy benefit;preference;Prevalence;primary care patient;primary care provider;primary outcome;Process;programs;Psychotropic Drugs;Quality of life;randomized trial;randomized, clinical trials;Research;Risk;Running;Sampling;scale up;Self Assessment;Self Direction;Self Management;Services;Sleep;sleep quality;smartphone application;System;Tablets;Testing;Time;tool;Treatment Protocols;Veterans;Work

PROJECT_TITLE: Promoting benzodiazepine cessation through an electronically-delivered patient self-management intervention

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ED_INST_TYPE: SCHOOLS OF LIBRARY SCIENCE

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: RELEVANCE {See instructions):  This research aims to make better use of existing health-related data by identifying new ways to analyze  it, potentially leading to groundbreaking discoveries like novel medical treatments. By measuring how data  is reused and fostering collaborations, the project serves public health by accelerating scientific  breakthroughs and improving our ability to fight diseases.

PI_NAMEs: HEMPHILL, LIBBY  (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TITLE: SoS:B10:ldentifying and Encouraging Connections among Data Reuse, Scientific Innovation, and Scientific Careers

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 GDB-T (SP)]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: RENO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because complications associated with preterm birth are the leading cause of infant mortality in the United States. This project is relevant to the NICHD mission because it will provide the foundation to determine if MMP9 or related pathway inhibitors can serve as druggable targets to promote uterine quiescence and reduce the number preterm births.

PI_NAMEs: BURKIN, HEATHER R (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Ablation;Affect;Amniotic Fluid;Animal Model;Automobile Driving;Birth;Birth Rate;Calcium;Calcium Signaling;Data;drug development;druggable target;enzyme activity;Event;experience;experimental study;Foundations;Future;Gap Junctions;Gelatinase A;Goals;health disparity;Human;human tissue;Impairment;improved;Infant;Infant Mortality;Inflammatory;inhibitor;Intervention;Metalloproteases;Mission;MMP9 gene;Modeling;Molecular;molecular drug target;Molecular Target;Mus;myometrium;National Institute of Child Health and Human Development;novel;novel therapeutics;Outcome;Oxytocin;Pathway interactions;Patients;perinatal health;pharmacologic;Pharmacologic Substance;Plasma;Play;Pregnancy;Pregnancy Outcome;Pregnant Uterus;premature;Premature Birth;Premature Labor;prevent;Process;Production;Proteomics;Public Health;Rattus;Regulation;Research;Research Priority;response;Role;SB 3CT compound;Serum;side effect;Signal Pathway;Signal Transduction;Technology;Testing;Tissues;United States;Uterine Contraction;Uterus;Woman;Yin

PROJECT_TITLE: MMP9 Modulation of Uterine Contraction and Birth Timing

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE  This proposed administrative supplement aims to address the complex intersection of HIV stigma, gender disparity, and cultural vulnerabilities faced by women living with HIV/AIDS (WLHA) in Vietnam. Through mentored implementation science research, the project will facilitate selection and adaptation of evidence- based, family-centered interventions to improve health outcomes for WLHA. Additionally, comprehensive hands-on training and mentoring will equip junior researchers in Vietnam with the skills necessary to become future leaders in implementation science, ensuring local capacity to sustain and expand these critical health improvement efforts for WLHA.

PI_NAMEs: LE, GIANG M;LEE, SUNG-JAE  (contact);LIN, CHUNQING

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Administrative Supplement;California;Collaborations;community advisory board;empowerment;Ensure;Evaluation;evidence base;Evidence based intervention;Face;Faculty;Family;Future;gender disparity;graduate student;Health;health care quality;health care service;Health system;Healthcare;HIV;HIV/AIDS;implementation science;improved;insight;interest;Intervention;Lead;Los Angeles;Medical;Mentors;Methodology;Outcome;programs;Research;Research Personnel;social stigma;stem;Structure;Thailand;tool;Training;Universities;Vietnam;Woman;Women's Health

PROJECT_TITLE: Cutting-edge, Customized, and Comprehensive (CCC) HIV capacity building for Vietnam and Thailand


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Kaposi's sarcoma (KS) is the most common cancer in people living with AIDS, and lymphomas are the second most common. The Kaposi sarcoma herpesvirus (KSHV) also called human herpesvirus 8 (HHV-8) is the etiologic agent of KS and some lymphomas. We will develop laboratory models that resemble diseases caused by KSHV, including the immune tumor microenvironment, which will allow us to test new treatments.

PI_NAMEs: CESARMAN, ETHEL  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: 3-Dimensional;Acquired Immunodeficiency Syndrome;Address;Affect;Africa South of the Sahara;AIDS related cancer;Animals;Antibody Therapy;Attention;B-Lymphocytes;Biopsy;Blood Vessels;candidate identification;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Line;Cells;checkpoint therapy;chemotherapy;Chronic;Clinical;common treatment;Complement 3d;Cytometry;Detection;Development;Disease;Drug Targeting;Elements;Endothelial Cells;Engineering;Environment;Etiology;Evaluation;Gene Expression;Genes;Genetically Engineered Mouse;Goals;Grant;Growth;histogenesis;HIV;Human;human disease;Human Herpesvirus 8;Hydrogels;Image;Immune;immune cell infiltrate;Immunocompetent;Immunodeficient Mouse;immunoregulation;immunosuppressed;Immunotherapy;Implant;In Vitro;in vivo;in vivo Model;Individual;Infection;Inflammatory;Inflammatory Infiltrate;Kaposi Sarcoma;Laboratories;Lead;Lesion;Lymphoma;Lymphoproliferative Disorders;Lytic;Macrophage;Malignant Neoplasms;mast cell;Messenger RNA;Methods;Modeling;mouse model;Multicentric Angiofollicular Lymphoid Hyperplasia;Mus;neoplastic cell;novel;novel therapeutics;organ transplant recipient;Organoids;Pathogenesis;Pathology;Patients;Pattern;Permeability;Persons;Pharmaceutical Preparations;Phenotype;Plasma Cells;pre-clinical;primary effusion lymphoma;Process;Proteins;Research;resistance mechanism;response;Rodent;Role;Schedule;Signal Transduction;Solid;System;T-Cell Depletion;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Tissues;Transcript;Translating;Translations;tumor;Tumor Biology;tumor microenvironment;tumor-immune system interactions;tumorigenesis;Viral Genes;Viral Genome;Viral Proteins;Virus;Virus Latency;Xenograft procedure

PROJECT_TITLE: (PQ 6) New Models of KSHV Oncogenesis and KS Immune Environment


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE - OVERALL An urgent need exists to develop better strategies for the prevention of cancer in high-risk subjects, and in particular, in those who have inherited a predisposition for the disease. In close collaboration with the NCI and other Centers, Fox Chase Cancer Center (FCCC) proposes to utilize multidisciplinary expertise, novel cutting-edge technology, and biospecimens and data from mutation carriers in the FCCC Risk Assessment Program to identify agents that can effectively disrupt the earliest steps in tumor formation. Establishment of FCCC as a member of a highly collaborative Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) is anticipated to accelerate the development of efficacious preventive agents and have a significant impact on reducing the burden of cancer among those at highest risk of disease.

PI_NAMEs: CLAPPER, MARGIE L. (contact)

PROGRAM_OFFICER_NAME: GUNASEKHARAN, VIGNESH KUMAR

PROJECT_TERMS: Acceleration;Address;Adult;African ancestry;Antibodies;Area;Atlases;Award;Barrett Esophagus;Bioinformatics;Biological Assay;biological specimen archives;Biometry;Cancer Biology;Cancer Burden;Cancer Center;cancer diagnosis;cancer prevention;cancer risk;Cell Line;Chronic;clinical risk;clinically relevant;cohort;Collaborations;Colonic Polyps;Communication;Computational Biology;Contractor;Data;data management;data sharing;Development;Disease;disorder risk;Division of Cancer Prevention;Dose;Drug Design;drug development;drug discovery;Early Detection Research Network;Early identification;Early treatment;efficacious intervention;efficacy study;Engineering;Epithelial Cells;Event;experience;Family;Fibroblasts;Fostering;Fox Chase Cancer Center;Future;Genetic Risk;genetic variant;Germ-Line Mutation;Goals;Growth;Hereditary Malignant Neoplasm;Hereditary Neoplastic Syndromes;Heritability;high risk;High-Risk Cancer;improved;In Vitro;in vivo;in vivo evaluation;Individual;individualized prevention;Informatics;Inherited;innovation;insight;Intercept;Intervention;Knowledge;Laboratory Research;Lead;Leadership;Lesion;Li-Fraumeni Syndrome;lifetime risk;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical Genetics;member;Missense Mutation;Molecular;Molecular Abnormality;molecular modeling;Molecular Profiling;Molecular Target;mouse model;multidisciplinary;mutant;Mutation;mutation carrier;netrin-G1;neutralizing antibody;novel;Operative Surgical Procedures;Oral Leukoplakia;Organ;overexpression;Pancreas;Pancreatic Intraepithelial Neoplasia;Pathogenicity;Pathway interactions;Phenotype;Population;pre-clinical;precision cancer prevention;Predisposition;premalignant;prevent;Prevention strategy;Preventive;preventive intervention;Productivity;programs;prophylactic;Proteins;public database;rational design;Regimen;Research;Research Personnel;Resource Sharing;Resources;Risk Assessment;Risk Reduction;screening;small molecule;targeted agent;Technology;therapy development;time use;Toxic effect;TP53 gene;Training;tumor;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;Validation

PROJECT_TITLE: Novel small molecule agents to correct pathogenic VHL missense mutations


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: CHARLESTON

ORG_NAME: LOXIGEN, INC.

ORG_STATE: SC

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because the goal is to develop novel and highly potent LOX inhibitors to overcome chemotherapy resistance in triple negative breast cancer (TNBC), a highly aggressive subpopulation of breast cancer with worse survival. Once we develop LOX inhibitors with excellent drug-like properties, there is a significant potential to improve the treatment of chemotherapy-resistant TNBC patients with high LOX expression. Thus, the proposed project is relevant to the part of the NIH’s mission that pertains to reducing illness and disability.

PI_NAMEs: SAHIN, OZGUR  (contact)

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: 3-Dimensional;Address;aggressive breast cancer;Antibody-drug conjugates;Benchmarking;Binding;Binding Proteins;Biological Assay;Biological Availability;Biometry;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;breast surgery;Caco-2 Cells;Cancer Biology;cancer subtypes;Canis familiaris;Cardiotoxicity;Cell Line;Cells;cellular targeting;Cessation of life;Chemoresistance;Chemosensitization;chemosensitizing agent;chemotherapy;clinically relevant;Collagen;Communication;crosslink;Death Rate;Dedications;design;disability;Doxorubicin;drug candidate;drug discovery;Drug Kinetics;effective therapy;Extracellular Matrix;Fibronectins;genotoxicity;Goals;Grant;Hypoxia;Immunocompetent;immunodeficiency;Immunotherapy;improved;In Vitro;in vitro Assay;in vivo;Induction of Apoptosis;inhibitor;Lead;lead optimization;Legal patent;Libraries;Malignant Breast Neoplasm;Mammary Neoplasms;Maximum Tolerated Dose;Mediator;Medical Oncology;member;Metabolic;meter;Mission;Modeling;Modification;Monoamine Oxidase;mouse model;mRNA Expression;Mus;Nature;novel;Oral;Organoids;Outcome;overexpression;patient derived xenograft model;Patients;Penetration;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacophore;Phase;Phenotype;Phosphotransferases;Plasma Proteins;Property;protein expression;Protein-Lysine 6-Oxidase;PTK2 gene;Public Health;Reaction;Resistance;Safety;screening;Serum Proteins;Signal Transduction;Small Business Technology Transfer Research;small molecule libraries;Solubility;Specificity;Structure-Activity Relationship;success;synergism;Testing;Therapeutic;therapy resistant;Time;Toxic effect;translational potential;treatment strategy;triple-negative invasive breast carcinoma;tumor;United States National Institutes of Health

PROJECT_TITLE: Developing novel LOX inhibitors to target chemotherapy resistant TNBC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-T(10)B]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE  Individual humans and animals can lie anywhere along a continuum of high to low risk-taking propensity. Both extremes of risk-taking propensity are thought to contribute to problematic behavior in several neuropsychiatric conditions, such as pathological anxiety and anorexia nervosa (low risk-taking propensity), and gambling disorder and substance abuse disorder (high risk-taking propensity). This project will develop, optimize, and mechanistically test a novel risky decision-making assay for use in screening for novel therapeutics, and eventual translation to humans.

PI_NAMEs: DULAWA, STEPHANIE C (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Agonist;Animals;Anorexia Nervosa;antagonist;Behavior;behavior measurement;Behavioral;Behavioral Assay;Biological Assay;Biological Markers;Brain;Brain region;Corpus striatum structure;Decision Making;Disease;Dopamine;Dopamine Receptor;Drug Screening;Drug usage;drug use screening;Exhibits;Fiber;Future;Gambling;Goals;high risk;Human;improved;in vivo;Individual;Infusion procedures;innovation;maladaptive behavior;Measures;Medial;Motivation;Neurons;neurophysiology;neuropsychiatry;novel;novel therapeutics;Nucleus Accumbens;optogenetics;Outcome;Parkinson Disease;Pathological anxiety;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Phase;Photometry;Play;Population;pramipexol;pre-clinical;Prefrontal Cortex;Rattus;receptor;Reporting;response;Rewards;Risk;Risk Marker;Risk Taking;Role;screening;sex;Structure;Substance abuse problem;Substance Use Disorder;Testing;therapeutic development;translation to humans;translational study;Ventral Striatum;Work

PROJECT_TITLE: Neurophysiological biomarkers in preclinical assays of risk propensity

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care

ORG_CITY: WINSTON SALEM

ORG_NAME: DIGITAL HEALTH NAVIGATION SOLUTIONS, LLC

ORG_STATE: NC

PHR: This STTR project will establish the feasibility, effectiveness, and value of a cloud-based digital health navigation program (mPATH™) that helps patients get screened for colorectal cancer, the second leading cause of cancer death in the United States. By addressing the multilevel barriers to care, mPATH™ could fill a critical need for an easily scalable commercial solution for colorectal cancer screening that could be expanded to other preventive services.

PI_NAMEs: MILLER, DAVID P (contact)

PROGRAM_OFFICER_NAME: ZHAO, MING

PROJECT_TERMS: accountable care organization;Address;Adult;Advisory Committees;Age;aged;American;barrier to care;Cancer Etiology;Caring;Cessation of life;cloud based;Colonoscopy;Colorectal Cancer;colorectal cancer screening;commercialization;Communities;cost;Cost Analysis;COVID-19;Devices;digital;digital health;Effectiveness;effectiveness testing;Electronics;Eligibility Determination;empowerment;Ensure;Environment;Ethnic Population;Feces;Federally Qualified Health Center;Feedback;Focus Groups;Future;Goals;health care service organization;health care settings;health disparity;Health system;Health Technology;Healthcare Systems;Home;innovation;Knowledge;Learning;Medical;medical schools;member;Modeling;Outcome;outreach;patient portal;Patients;Phase;pilot trial;Population Heterogeneity;Preventive care;Preventive service;primary care practice;primary outcome;programs;Publications;Race;Randomized, Controlled Trials;Reporting;response;Risk;Rural;Schedule;screening;screening guidelines;screening services;secondary analysis;Site;Small Business Technology Transfer Research;Source;Spanish/English;Stream;Subgroup;Tablets;Technology;Testing;Text;Text Messaging;Time;Training;United States;United States Preventative Services Task Force;Universities;Update;uptake;usability;Visit;web app;Work

PROJECT_TITLE: A cloud-based digital health navigation program for colorectal cancer screening

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-J(10)B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Genetics;Mental Health;Muscular Dystrophy;Myotonic Dystrophy;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative This administrative supplement proposal is an extension of an existing award (K23 NS125110). Measures of white matter integrity derived from brain MRI are expected to be disease-specific and clinically relevant to clinical (cognitive and motor) endpoints and fluid biomarkers of brain pathology in adults with myotonic dystrophy type 2 (DM2). This project will inform the development of rigorous trial designs and a subsequent R01 study to evaluate longitudinal changes of white matter integrity and fluid biomarkers of brain pathology as measures of disease progression and therapeutic response in DM2.

PI_NAMEs: PUWANANT, ARAYA  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acceleration;Address;Administrative Supplement;Adult;Affect;Age;Age related comorbidities;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloid beta-Protein;Anisotropy;Area;Attention;Award;Biological Assay;Biological Markers;Brain;Brain imaging;brain magnetic resonance imaging;Brain Pathology;Central Nervous System;Cerebrum;Clinical;clinically relevant;Cognition;Cognitive;Cognitive deficits;cognitive function;Collaborations;Collection;Communities;comparison control;Deposition;Development;Diffusion Magnetic Resonance Imaging;disabling symptom;Disease;Disease Progression;Ensure;Episodic memory;executive function;falls;Fostering;Funding;Future;gain of function;Gait speed;Gene Proteins;Grant;gray matter;Hand Strength;imaging study;Impaired cognition;Impairment;Infrastructure;interest;Liquid substance;Literature;Magnetic Resonance Imaging;Measures;Memory;Mentored Patient-Oriented Research Career Development Award;Methods;mild cognitive impairment;morphometry;Motor;Muscle Weakness;Myotonic dystrophy type 2;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurobehavioral Manifestations;Neurobiology;Neurofibrillary Tangles;Neuromuscular Diseases;normal aging;nucleic acid binding protein;Parents;Pathology;Patients;Performance;Phosphorylation;Plasma;pre-clinical;preservation;processing speed;Protein Isoforms;Quality of life;Radial;Rare Diseases;Reporting;repository;Request for Applications;Research;Resources;RNA;RNA Splicing;Role;Sampling;sex;Structure;success;tau Proteins;Testing;therapeutic development;treatment response;trial design;verbal;white matter;white matter change;Work

PROJECT_TITLE: Brain Structure and Clinical Endpoints in Myotonic Dystrophy Type 2-

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: ADAMS, ALYCE SOPHIA (contact)

PROGRAM_OFFICER_NAME: HARDESTY, REBECCA ANNE

PROJECT_TERMS: Achievement;Address;Award;broadening participation research;California;Cancer Control;Cancer Etiology;cancer prevention;career;Career Choice;career development;Centers for Population Health;Communities;community engagement;community partners;Comprehensive Cancer Center;Data;Development;Equity;experience;Extramural Activities;Family;Fostering;Funding;Goals;Grant;Health Sciences;Income;Income Tax;Inequality;Inequity;innovation;interdisciplinary collaboration;Intervention;Leadership;Link;Malignant Neoplasms;Mentors;Mission;novel;Pathway interactions;Peer Review Grants;Pilot Projects;Play;Policies;poor communities;Poverty;Poverty Areas;programs;Research;Research Methodology;Research Personnel;San Francisco;Secure;social determinants;synergism;Universities;Work

PROJECT_TITLE: Developmental Core


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Women's Health Research

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT 1 | NARRATIVE Breast cancer is a leading cause of death for women in the United States and around the globe. An early event in development of breast cancer is the epithelial-to-mesenchymal transition (EMT) when mammary cells lose their normal structure and function and gain migratory and invasive properties. Project 1 studies will investigate mitotic gene bookmarking—mitotic retention of transcription factors with target genes on chromosomes for transcriptional regulation in progeny cells—as an epigenetic mechanism to maintain normal mammary epithelial cell identity. We will determine whether compromised mitotic bookmarking by the RUNX1 transcription factor results in initiation of EMT and onset of breast cancer. Findings will have far reaching impact on development of new approaches to identify and therapeutically target early events in breast cancer development.

PI_NAMEs: STEIN, GARY S. (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: acute myeloid leukemia 1 protein;Biological;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;breast cancer progression;Breast Epithelial Cells;Bromodomain;cancer cell;cancer initiation;Cause of Death;Cell division;Cell Line;Cell Proliferation;Cells;ChIP-seq;Chromatin;Chromosomes;Clinical;clinically relevant;Collaborations;CRISPR screen;Data;Development;Developmental Process;Dimensions;DNA Binding;Epigenetic Process;epigenome;Epithelial Cell Proliferation;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Equilibrium;Estrogen receptor positive;Estrogen Receptors;Estrogens;Event;Gene Expression;Genes;Genetic Transcription;Genome;Genomic approach;Genomic Segment;Genomics;Growth;Hi-C;histone modification;Histones;hormone therapy;in vivo;innovation;Knowledge;Link;live cell microscopy;loss of function;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;mammary epithelium;Mammary Neoplasms;Maps;Mediating;Mitosis;Mitotic;Mitotic Chromosome;Modeling;Molecular;Mutation;Neighborhoods;novel;novel strategies;nuclease;Outcome;pharmacologic;Phenotype;Physiological;Play;Precision Run-On Sequencing;preservation;prevent;programs;Property;Proteins;Receptor Signaling;Regulation;Research Personnel;Resistance;Resolution;Role;RUNX1 gene;Signal Transduction;Specimen;Structure;Supporting Cell;Testing;therapeutic target;transcription factor;Transcriptional Regulation;transcriptome;tumor;tumor progression;United States;Validation;Women's mortality

PROJECT_TITLE: Project 1: Mitotic Gene Bookmarking as an Epigenetic Mechanism to Maintain the Mammary Epithelial Phenotype


ORG_CITY: PITTSBORO

ORG_NAME: ENFUEGO THERAPEUTICS INC.

PHR: Project Narrative  KRAS mutations represent one of the most common molecular etiologies of cancer and confer high mortality rates in a broad range of organ malignancies including lung, colon, and pancreas. Selectively eliminating mutant forms of the protein while retaining normal nonmalignant KRAS protein is extremely challenging for conventional therapeutic strategies. EnFuego Therapeutics has developed a novel, ligand- directed siRNA-based technology capable of suppressing mutant KRAS while sparing wild type transcripts. These compounds also exhibit hallmark characteristics of effective targeted therapies, including serum stability, cancer growth inhibition, and abrogation of oncogenic downstream KRAS signaling. This Fast Track proposal will focus on the optimization of select EnFuego compounds which target G12V mutant KRAS in lung cancer, a mutation that is intractable for other therapeutic strategies and contributes 22% of all KRAS-associated lung cancer cases.

PI_NAMEs: PECOT, CHAD V;STANLAND, LYLA  (contact)

PROGRAM_OFFICER_NAME: FRANCA-KOH, JONATHAN C

PROJECT_TERMS: Ablation;Acceleration;Address;Affinity;Biodistribution;Biological;cancer cell;Cancer cell line;Cancer Etiology;Cancer Model;cancer therapy;Cell Proliferation;Cessation of life;Characteristics;Chemicals;Chemistry;Circulation;Colon;Data;Death Rate;Development;Drug Kinetics;Drug Targeting;Endosomes;Epidermal Growth Factor Receptor;Exhibits;feasibility testing;Genes;Genetic Engineering;Growth;Half-Life;Hepatocyte;Hour;Human;Immune;improved;In Vitro;in vivo;Investigational Drugs;Investigational New Drug Application;Kidney;kinase inhibitor;knock-down;KRAS oncogenesis;KRAS2 gene;Lead;Libraries;Ligands;lipid nanoparticle;Liquid substance;Liver;locked nucleic acid;Lung;Lung Adenocarcinoma;lung cancer cell;Lung Neoplasms;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;Modeling;Modification;Molecular;Molecular Abnormality;mouse model;Mus;mutant;Mutation;neoplastic cell;Non-Malignant;novel;novel therapeutic intervention;Nucleic Acids;Nucleotides;Oligonucleotides;Oncogenic;Operative Surgical Procedures;Organ;Pancreas;Pathway interactions;patient derived xenograft model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phase;phase 2 study;phase 2 testing;phosphorothioate;Phosphorylation;PIK3CG gene;preservation;programs;Proteins;Proto-Oncogenes;Readiness;RNA Interference;Safety;safety assessment;safety study;scale up;Serum;Signal Transduction;Small Business Innovation Research Grant;Small Interfering RNA;small molecule;subcutaneous;success;targeted treatment;Technology;Testing;Therapeutic;Thermodynamics;Tissues;Toxic effect;Transcript;tumor;Tumor Burden;United States;Vertebral column;Xenograft Model

PROJECT_TITLE: Ligand-Directed KRAS G12V Mutant-Specific Therapeutics


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Dental, Oral, and Craniofacial Disease;Neurosciences;Pain Research

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE  The University of Michigan (UM) PAIN Cohort T90/R90 is ideally suited to train the next generation of post-doctoral pain scientists. The program proposes inter-disciplinary mentoring and training of individuals from  disciplines not typically involved in pain research, with a heavy emphasis on training a wide variety of data  scientists as well as trainees from our School of Public Health (including biostatistics and epidemiology) and  College of Engineering (including computer science and biomedical engineering). By using a vast array of  available and willing mentors at UM not formally named on the grant, we will be able to provide each of our  Scholars both a junior and senior mentor, as well as an individual with learned experience, as part of their  mentoring team.

PI_NAMEs: CLAUW, DANIEL J (contact);KIDWELL, KELLEY MCLAIN;WIENS, JENNA

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: addiction;Anesthesiology;behavioral health;Bioinformatics;Biomedical Engineering;Biometry;Cannabis;career;Chronic;chronic pain;clinical pain;cohort;comorbidity;computer science;design;Discipline;Educational Curriculum;effective intervention;Engineering;Environmental Health;Epidemiologist;Epidemiology;Faculty;Fatigue;Grant;Hallucinogens;health equity;Helping to End Addiction Long-term;life span;Lived experience;Medicine;Mental Health;Mentors;Michigan;Names;next generation;non-opioid analgesic;Nonpharmacologic Therapy;Pain;pain chronification;Pain management;Pain Research;Patients;Persons;Pharmacological Treatment;Physicians;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Prevention;Program Evaluation;programs;Psychologist;Public Health;Research;Research Personnel;Research Training;Scientist;social;Social Sciences;Social Workers;Training;Universities;Work

PROJECT_TITLE: University of Michigan HEAL PAIN Cohort Program


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Hematology;Networking and Information Technology R&D (NITRD)

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative Vascular diseases are becoming epidemic with increase in aging population, obesity and type II diabetes. They affect humans of all age groups, including neonates. This proposal aims to develop and validate the first ever portable photoacoustic imager for diagnosing and monitoring vascular diseases in resource poor settings.

PI_NAMEs: KOTHAPALLI, SRI RAJASEKHAR (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3-Dimensional;absorption;Adipose tissue;Affect;Age;age group;aging population;Animals;Anticoagulants;Arteriovenous malformation;Award;Blood;Blood coagulation;Blood flow;Blood Vessels;Blood Volume;Brown Fat;Cause of Death;Chronic;Clinical;Clinical Research;Collaborations;Computer software;Computers;Contrast Media;cost;cost effective;Coupled;Darkness;Data;data acquisition;deep learning algorithm;Deep Vein Thrombosis;deoxyhemoglobin;design;Devices;Diagnosis;Diagnostic;Disease;Doppler Ultrasound;Electronics;Engineering;Epidemic;falls;Fiber Optics;Functional Imaging;Ghana;global health;Goals;Health;Health Personnel;Hemangioma;Hematoma;Hemoglobin;Hemorrhage;Hospitals;Human;Human Resources;Image;imager;imaging capabilities;Imaging Device;imaging platform;imaging system;Imaging technology;in vivo;India;Infant;Label;Lasers;Light;light emission;light scattering;Lighting;Lipids;Magnetic Resonance Imaging;Maps;Measurement;Measures;Medical;Medical center;miniaturize;Modeling;Molecular;Monitor;Morphologic artifacts;Motion;Multi-site clinical study;neonate;next generation;Noise;Non-Insulin-Dependent Diabetes Mellitus;Obesity;older patient;Optics;Oxygen;Patients;Performance;Peripheral arterial disease;phantom model;Phase;photoacoustic imaging;Physicians;point of care;Point of Care Technology;point-of-care diagnosis;Population Heterogeneity;portability;preclinical study;prognostic;programs;Radiation;Rattus;research clinical testing;Research Personnel;Resolution;Resource-limited setting;Risk;Science;screening;Screening procedure;Sensitivity and Specificity;Signal Transduction;Source;Statistical Data Interpretation;Stroke;Structure;System;Techniques;Technology;Testing;Time;tissue phantom;Tissues;transmission process;Ultrasonic Transducer;ultrasound;Vascular Diseases;Venous Insufficiency;Visualization

PROJECT_TITLE: A portable photoacoustic imager for diagnosing vascular diseases


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: College Station

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: Project Narrative This project aims to reveal the mechanisms of how single-stranded RNA bacteriophages (ssRNA phages) PP7 and AP205 package their genomic RNA to be delivered to Pseudomonas aeruginosa and Acinetobacter spp., respectively via the Type IV pili, by combining high-resolution cryo-electron microscopy, in-situ fluorescence microscopy, and multi-scale computational modeling. Unlike double-stranded DNA phages, ssRNA phages do not have pressurized capsids or dedicated DNA delivery machinery, and how ssRNA phages package and deliver RNA into the cell remains a mystery. Knowledge gained from this project will provide an alternative strategy for treating multidrug-resistant bacterial infections by specifically cleaving/stalling Type IV pili.

PI_NAMEs: ZENG, LANYING ;ZHANG, JUNJIE  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acinetobacter;Adsorption;Affect;Antibiotic Resistance;Bacteria;Bacterial Infections;Bacterial Pili;Bacteriophages;Binding;Binding Proteins;Biology;Capsid;Capsid Proteins;cell preparation;Cells;Coliphages;Color;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Cytosol;Data;Data Set;Dedications;DNA;DNA delivery;ds-DNA;Electroporation;Engineering;Enterobacteria phage MS2;Environment;Escherichia coli;experimental study;fluorescence imaging;Fluorescence Microscopy;Future;Genetic;Genetic Materials;genomic RNA;Goals;Gram-Negative Bacteria;Guidelines;Health Care Costs;Heat-Shock Response;Human;Image;In Situ;in situ imaging;Infection;insight;interest;kinetosome;Knowledge;Label;Life;Measures;member;Methods;Modeling;Molecular;Multi-Drug Resistance;multi-scale modeling;mutant;pathogen;pathogenic bacteria;Pathway interactions;Penetration;Pilum;plasmid DNA;Plasmids;Play;pressure;Process;Proteins;Pseudomonas;Pseudomonas aeruginosa;receptor;Regulation;Resistance;Resolution;RNA;RNA delivery;RNA Phages;Role;Site-Directed Mutagenesis;structural determinants;Structure;success;superresolution microscopy;Testing;time use;tool;Toxin;Virion;Virulence;Virulence Factors;Virus;Visualization;Work

PROJECT_TITLE: RNA penetrations into bacteria.

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: The fellows and mentors trained by this program will contribute to short- and long-term improvements in global health. In collaboration with 21 low- and middle-income country institutions, fellows’ research will help develop clear and effective programs and policies to advance global public health, including care for HIV, other infectious diseases, noncommunicable diseases, global surgery, cancer, mental health and addiction, sexual and reproductive health, and planetary health.

PI_NAMEs: COHEN, CRAIG R (contact);LEE, SUNG-JAE ;MARTIN, NATASHA ;MARTÍNEZ-LÓPEZ, BEATRIZ

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TERMS: burden of illness;California;career;career development;Collaborations;Country;Dentistry;design;Discipline;Discipline of Nursing;Ensure;Environmental Science;Equity;Evaluation;experience;faculty mentor;Faculty Recruitment;Fellowship;Fostering;Funding;global health;Goals;hands on research;Health;improved;Income;innovation;Institution;Instruction;Interdisciplinary Education;Leadership;Los Angeles;Medicine;Mentors;Mentorship;Modeling;online course;Personal Satisfaction;Postdoctoral Fellow;pre-doctoral;programs;Public Health;Race;recruit;Research;Research Methodology;Resources;response;San Francisco;Site;Social Sciences;success;Training;Training and Education;Training Programs;Underrepresented Minority;Universities;veterinary science;Work

PROJECT_TITLE: GloCal - OAR - Semulimi


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PI_NAMEs: COLE, ALLISON ;DAVIS, MELINDA MARIE (contact);MORRIS, CYNTHIA D

PROGRAM_OFFICER_NAME: QASHU, FELICIA M

PROJECT_TERMS: Adopted;Alaska;American;Applied Research;Censuses;Clinic;Clinical and Translational Science Awards;clinical care;Clinical Research;clinical research site;Clinical Trials;Collaborations;Communication;Communities;community engagement;Community Healthcare;community setting;Complement;Contracts;Data;Doctor of Philosophy;Education;Enrollment;experience;Foundations;frontier;Funding;Future;Grant;Health;health equity;Health Policy;Healthcare;Idaho;Individual;Industry;Infrastructure;innovation;Institution;Lead;Leadership;Learning;Location;member;Montana;Oregon;Participant;participant enrollment;Policies;practice-based research network;Primary Care;primary care clinic;Procedures;Process;programs;recruit;Research;Research Design;Research Institute;research study;Resource-limited setting;Rural;rural area;Rural health equity;rural patients;rural setting;Science;Site;support network;translational health science;Translational Research;underserved community;United States National Institutes of Health;Universities;Washington;whole health;Work;Wyoming

PROJECT_TITLE: The Primary Care Rural and Frontier Clinical Trials Innovation Center (PRaCTICe)


ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: Projective Narrative Characterizing the regulation and substrate recognition for the metalloproteases ADAMTS13 and ADAMTS7 will open new avenues for investigation towards understanding important cardiovascular diseases like thrombosis and atherosclerosis. Understanding how dysregulation of these proteases contributes to disease will enable the development of new tools for diagnosis as well as therapeutic targets for treatment and prevention.

PI_NAMEs: MUIA, JOSHUA MUTAMBUKI (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Address;Adopted;Allosteric Regulation;Atherosclerosis;Biochemical;biochemical tools;Bioinformatics;Biological Process;Blood coagulation;Blood Coagulation Disorders;Cardiovascular Diseases;Catalysis;Coronary Arteriosclerosis;Defect;Development;Diagnosis;Disease;Disintegrins;Elements;Enzymatic Biochemistry;Enzymes;Family;Foundations;Goals;human disease;improved;Inflammation;Inflammatory;Inherited;Investigation;Kinetics;Literature;member;Metalloproteases;Methods;Modeling;Molecular Conformation;novel;Outcome;Peptide Hydrolases;Prevention;Principal Investigator;Property;protein protein interaction;Proteomics;Reagent;recruit;Regulation;Reporting;Research;small molecule inhibitor;student mentoring;therapeutic target;Thrombosis;Thrombospondins;tool;translational applications;von Willebrand Factor;Work

PROJECT_TITLE: Investigating the regulation and substrate processing of ADAMTS13 and ADAMTS7 metalloproteases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Microbiome

ORG_CITY: ANN ARBOR

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: NARRATIVE Although peri-implantitis occurs in 1/10th of all implants, and peri-implant mucositis in 60% of implants, our ability to treat and prevent these diseases is severely hampered by a lack of knowledge of the causative factors and mechanisms of disease. The proposed studies represent the first comprehensive visual and molecular atlas of the peri-implant environment from moment of its formation to the onset of disease. This functional and spatial characterization will bring us closer to understanding the mechanisms underlying the pathogenesis of these disease and provide biologically-validated timelines for risk assessment.

PI_NAMEs: KUMAR, PURNIMA  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Algorithmic Analysis;Animal Model;Architecture;Area;arm;Atlases;bacteriome;Behavior;Bioinformatics;Biological;biomarker identification;Chemistry;Chronic;Chronology;Clinical;clinical epidemiology;Clinical Research;combinatorial;Communities;Data;data integration;data repository;Dental Implants;Development;Disease;Disease susceptibility;Ecosystem;Environment;Equilibrium;Event;Genes;Genetic Transcription;Goals;Graph;Growth;Health;Homeostasis;host microbiome;Human;Image;Image Analysis;image guided;Immunity;Implant;improved;In Vitro;in vitro Model;Individual;Inflammatory;Investigation;Knowledge;Label;Liquid substance;man;Maps;Marketing;Mastication;Metabolic Pathway;Metagenomics;metatranscriptome;metatranscriptomics;microbial;microbial community;microbial homeostasis;microbial host;microbiome;Molecular;Mucositis;Mucous Membrane;multilevel analysis;mutualism;mycobiome;novel;Onset of illness;Outcome;Pathogenesis;Pathway Analysis;peri-implantitis;Physiology;prevent;Research;Research Design;Resources;Risk;Risk Assessment;Shapes;Signal Transduction;soft tissue;spectrograph;Surface;Survival Rate;Systems Biology;Testing;Time;time use;timeline;Tissues;Titanium;Tooth structure;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Viral;virome;Virus;Visual

PROJECT_TITLE: Biogeography of the peri-implant microbial ecosystem in health and during transition to disease


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Most oral cancers are preceded by clinical lesions called oral potentially malignant disorders (OPMDs). The objective of this proposal is to develop a multimodal imaging based OPMD diagnostic platform that integrates Fourier transform infrared spectroscopic imaging with histological imaging and spatial transcriptomics, aided by advanced machine learning and deep learning techniques. This novel platform can potentially allow clinicians to make objective, accurate, and personalized risk assessment for individual OPMD patients and facilitate early oral cancer detection.

PI_NAMEs: WANG, RONG  (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: Affect;base;Benign;Biochemical;Biological;Biometry;Cancer Biology;cell type;Cessation of life;Clinical;clinical diagnostics;Collection;Complex;Data;Data Analyses;deep learning;deep learning algorithm;deep learning model;Detection;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic platform;Discrimination;Disease;disease diagnosis;Disease Management;disorder risk;Early Diagnosis;Epithelium;Evaluation;Feasibility Studies;feature extraction;Fingerprint;Formalin;Fourier Transform;Gene Expression;Gene Expression Profile;Gene Expression Profiling;global health;Histologic;histological image;Image;Image Analysis;Imaging Techniques;improved;Individual;innovation;interest;Investigation;Learning;Lesion;Machine Learning;machine learning algorithm;machine learning model;Malignant - descriptor;malignant mouth neoplasm;Medical;Modality;model development;Modeling;Molecular;Morphology;mouth squamous cell carcinoma;multidisciplinary;Multimodal Imaging;National Institute of Dental and Craniofacial Research;Nature;novel;Oral;Oral Diagnosis;oral lesion;Oral Medicine;Oral mucous membrane structure;Oral Pathology;Paraffin Embedding;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern Recognition;Performance;predictive modeling;premalignant;Premalignant Cell;Prevention;Prognosis;Research;Risk;Risk Assessment;risk stratification;Sampling;Screening for Oral Cancer;spectroscopic imaging;success;Survival Rate;Techniques;Technology;Testing;Tissue imaging;Tissues;tool;transcriptomics;Work

PROJECT_TITLE: Decoding FTIR-based multimodal imaging for risk assessment of precancerous oral lesions

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Chronic Pain;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Neurosciences;Orphan Drug;Pain Research;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Narrative Pain management is a significant problem in oral cancer patients. Importantly, the mechanisms of oral cancer pain are incompletely understood, and this impedes development of novel analgesics, We propose a novel mechanism of oral cancer pain that will provide knowledge for future research at developing drugs for not only pain management but also cancer treatment. Specifically, the current application proposes to study role of truncated TrkB isoform in mediating pain at the site of tumor development. Given that TrkB contributes to tumor progression, targeting this receptor signaling can prove to be efficacious therapy for cancer-induced pain as well as tumor progression.

PI_NAMEs: RUPAREL, SHIVANI B (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Address;Afferent Neurons;Analgesics;Area;Attention;Automobile Driving;Biology;Brain-Derived Neurotrophic Factor;cancer cell;cancer pain;Cancer Patient;cancer therapy;cancer type;Capsaicin;carcinogenesis;cell type;Cells;clinically significant;conditional knockout;Data;Development;Disease;Effectiveness;efficacious treatment;FDA approved;Fiber;Flow Cytometry;Functional disorder;Gene Expression;Goals;Head and Neck Cancer;Human;Immune;Impairment;improved;In Vitro;inhibitor;innovation;insight;interest;knock-down;Knowledge;Length;Light;Link;Malignant Epithelial Cell;malignant mouth neoplasm;malignant tongue neoplasm;Mechanics;Mediating;Medical;Microscopy;Molecular;Morbidity - disease rate;mouse model;Mouth Neoplasms;mouth squamous cell carcinoma;Mus;Nerve;Neuronal Plasticity;neuronal tumor;Neurons;Neurotrophic Tyrosine Kinase Receptor Type 2;new therapeutic target;Nociceptors;non-opioid analgesic;nonhuman primate;novel;novel strategies;novel therapeutics;Opioid;oral tumorigenesis;Orofacial Pain;overexpression;Pain;pain behavior;Pain management;Pain Measurement;pain relief;Painless;Patients;Peripheral;Pharmaceutical Preparations;Phosphotransferases;Protein Isoforms;Quality of life;receptor;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Regulation;release factor;Research;Research Project Summaries;Role;Sampling;single cell analysis;single-cell RNA sequencing;Site;small molecule inhibitor;Symptoms;Testing;Time;Tissues;Tongue;Tongue Neoplasms;transcriptome sequencing;transcriptomics;transmission process;Trigeminal System;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor-Derived

PROJECT_TITLE: Contribution of Truncated TrkB Isoform in Oral Cancer Pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Radiation Oncology;Rare Diseases;Regenerative Medicine

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Narrative This project is to determine functions of specific microRNAs in enhancing bone formation and repressing bone resorption under anti-cancer radiation. We will demonstrate the feasibility of local microRNA application to improve surgical reconstruction outcomes of oral cancer treatment. We will also reveal the potential molecular and cellular effects of radiation on osteogenesis and osteoclastogenesis and microRNA functions.

PI_NAMEs: CAO, HUOJUN ;HONG, LIU  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3D Print;Adjuvant;Adjuvant Radiotherapy;Adverse effects;alveolar bone;Animal Model;anti-cancer;Anti-Inflammatory Agents;Attenuated;Biological Process;bone;bone healing;bone invasion;bone metabolism;Bone Regeneration;Bone Resorption;Bone Transplantation;Calvaria;cancer therapy;Cephalic;chemoradiation;Collagen;craniofacial bone;cytokine;Defect;Dose;Down-Regulation;Epigenetic Process;Excision;Exposure to;Failure;Funding;Goals;Grant;Human;Impairment;Implant;improved;improved outcome;Infection;Inflammation;Inflammatory;innovation;Knockout Mice;Macrophage;Malignant Bone Neoplasm;malignant mouth neoplasm;Mandible;Maxilla;Measures;Mediating;Mediator;Messenger RNA;Methods;MicroRNAs;Molecular;mouse model;mouth squamous cell carcinoma;nanoparticle;novel;novel therapeutics;Oral;Oral Stage;Osseointegration;osteoclastogenesis;Osteogenesis;osteogenic;Outcome;overexpression;Pathogenesis;Patients;plasmid DNA;Play;Porifera;Postoperative Period;pre-clinical;prevent;protective effect;Radiation;radiation effect;Radiation exposure;Radiation therapy;Rattus;Recommendation;Reconstructive Surgical Procedures;Recurrence;Recurrent tumor;Repression;Research;restoration;Role;scaffold;Signal Pathway;Solid;standard of care;Stress;surgery outcome;Survival Rate;Therapeutic;therapeutic miRNA;therapeutically effective;tool;tumor;Untranslated RNA;Variant;WNT Signaling Pathway

PROJECT_TITLE: Oral and Craniofacial Bone Regeneration using MicroRNA Modulation

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

PHR: Narrative Eighty percent of children with advanced or metastatic sarcoma will die from disease despite aggressive multimodality therapy. In this proposal we aim to define less-toxic and more effective targeted therapeutic approaches in high-risk RAS-driven Embryonal Rhabdomyosarcoma (ERMS) by using patient-derived xenograft models, omics and novel single-mouse testing approaches. Our focus is inhibition of MAPK signaling as potential therapeutic strategy to treat ERMS.

PI_NAMEs: VASEVA, ANGELINA V (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Apoptosis;Biological Assay;Cell Cycle Arrest;Cell Line;chemoradiation;chemotherapeutic agent;chemotherapy;Chemotherapy and/or radiation;Chemotherapy-Oncologic Procedure;Child;Classification;Clinical;Clinical Protocols;Clinical Trials;Clinical Trials Design;Clonal Evolution;Codon Nucleotides;Combination Drug Therapy;Combined Modality Therapy;Data;Diagnosis;Disease;DNA Damage;DNA Repair;DNA sequencing;Dose;Down-Regulation;Embryonal Rhabdomyosarcoma;epigenomics;Event;Experimental Designs;FRAP1 gene;Generations;Genetic;genetic manipulation;Genomics;genotoxicity;Goals;high risk;Immunohistochemistry;improved;improved outcome;in vivo;in vivo Model;inhibitor;innovation;Intervention;knock-down;Lesion;Life;MAP Kinase Gene;MAPK Signaling Pathway Pathway;MEK inhibition;MEKs;Mitogen-Activated Protein Kinase Inhibitor;Modeling;Mus;mutant;Mutation;NF1 gene;novel;Oncogenic;Operative Surgical Procedures;Outcome;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pharmacodynamics;PIK3CG gene;Pilot Projects;pre-clinical;preclinical evaluation;Protein Isoforms;Proto-Oncogene Proteins c-akt;protocol development;Protocols documentation;Radiation therapy;Recurrence;Regimen;Regulation;research clinical testing;Resistance;resistance mechanism;response;response biomarker;Rhabdomyosarcoma;Role;Sarcoma;Schedule;screening;Signal Transduction;synergism;targeted treatment;Testing;Therapeutic;Toxic effect;transcriptome sequencing;Translations;treatment response;tumor;tumor xenograft;Vincristine;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Improving Therapeutic Approaches for RAS-driven Rhabdomyosarcoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Genetics;Lung;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Accidental exposure to the halogen gas, chlorine (Cl2), causes fatal lung injury characterized by profound airway inflammation, pulmonary edema and acute respiratory failure. Survivors often display persistent reactive airway disease and progressive pulmonary fibrosis. This study will determine if mitochondria DNA damage underlies Cl2 toxicity and whether repairing mitochondrial DNA can reduce morbidity and mortality.

PI_NAMEs: GILLESPIE, MARK N;MATALON, SADIS  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Accidents;Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Acute respiratory failure;Address;Adenovirus Vector;Adult;Air;Airway Disease;airway epithelium;airway inflammation;alveolar epithelium;Alveolar Macrophages;Animal Model;Bioenergetics;Biological Markers;Cell Death;cell injury;cell type;Cells;Chemicals;Chlorine;chlorine gas;Chronic;Chronic Lung Injury;Chronic Obstructive Pulmonary Disease;cytokine;cytotoxic;Data;Development;Disease;Distal;DNA Damage;DNA glycosylase;Effector Cell;Elements;Endosomes;Epithelial Cells;epithelial Na+ channel;Epithelium;Etiology;Event;experimental study;exposed human population;Exposure to;extracellular;Female;Functional disorder;gas induced lung injury;Gases;genome integrity;Halogens;Human;human subject;improved;In Vitro;in vivo;indexing;Inflammation;Inflammatory;Inhalation;Injury;innovation;Intranasal Administration;Ion Transport;Kinetics;Knockout Mice;Light;Link;Lung;lung injury;Macrophage;Maintenance;male;Measures;Mediating;Membrane Potentials;Methodology;Mitochondria;Mitochondrial DNA;mitochondrial genome;mitochondrial membrane;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;Mus;novel;Nuclear;Nucleic Acids;OGG1 gene;outcome prediction;oxidant stress;oxidative damage;Oxygen Consumption;Pathologic;Pathway interactions;Pattern;Pattern Formation;pharmacologic;Physiological;Plasma;Publishing;Pulmonary Edema;Pulmonary Fibrosis;Reactive Oxygen Species;receptor;Receptor Activation;Recombinants;reconstitution;regenerative;repaired;Reporting;Rodent;Seminal;Sentinel;Severities;Signal Transduction;Slice;small hairpin RNA;Small Interfering RNA;Sodium Channel;Stimulator of Interferon Genes;Surrogate Markers;Survivors;Symptoms;Testing;Time;Toxic effect;trafficking;Transgenic Mice;Type II Epithelial Receptor Cell;weapons;Work

PROJECT_TITLE: Mitochondrial DNA Injury is a Key Contributor to the Development of Chemical Lung Injury

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Patient Safety;Physical Activity;Prevention

ORG_CITY: Chicago

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Middle to older aged adults with overweight or obesity and cardiometabolic comorbidities, especially minorities, appear most vulnerable to secondary health effects of the COVID-19 pandemic. To confront this public health crisis, the current Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and Older (PIVOT) aims to expand access to simple, effective lifestyle interventions for weight loss and behavior change using electronic health record systems and wearable devices. This study can enable accelerated deployment of effective digital behavioral health interventions at scale to reduce disease burden in aging adults with lifestyle- related multiple chronic conditions.

PI_NAMEs: KANNAMPALLIL, THOMAS GEORGE;MA, JUN  (contact);VENDITTI, ELIZABETH MARY

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Acceleration;Accelerometer;adaptive intervention;Address;Administrative Supplement;Adopted;Adult;aged;Aging;base;behavior change;Behavior Therapy;Behavioral;behavioral health intervention;Body mass index;Body Weight decreased;burden of illness;cardiometabolism;Characteristics;Chronic;Clinical;clinical predictors;clinically significant;comorbidity;Computer software;Control Groups;cost;COVID-19 pandemic;COVID-19 pandemic effects;Data;data acquisition;data exchange;design;Devices;diabetes prevention program;digital;digital health;digital intervention;Effectiveness;Effectiveness of Interventions;Electronic Health Record;electronic health record system;eligible participant;Emerging Technologies;Equilibrium;experience;fitbit;follow-up;Goals;Habits;Health;health disparity;Health system;human old age (65+);Individual;individual patient;innovation;Institution;Insurance Carriers;interest;Intervention;intervention delivery;intervention effect;Intervention Trial;Life Style;lifestyle intervention;Machine Learning;middle age;Minority;Monitor;Motivation;Multi-Institutional Clinical Trial;multiple chronic conditions;Obesity;older adult;Overweight;pandemic impact;parent grant;parent project;Participant;patient health information;Patient Outcomes Assessments;point of care;Policies;preservation;Problem Solving;Protocols documentation;Public Health;Randomized;randomized, clinical trials;recruit;Resources;response;Sample Size;Secondary to;Self Direction;Sequential Multiple Assignment Randomized Trial;Site;sociodemographics;Spanish/English;Tablets;Target Populations;Technology;Testing;Training;translational potential;Translational Research;Treatment Efficacy;trial design;unhealthy lifestyle;videoconference;Videoconferencing;Waiting Lists;wearable device;Weight;Weight Gain;weight loss intervention;wireless;Work


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: OWINGS MILLS

ORG_NAME: ASELL, LLC

ORG_STATE: MD

PHR: Under the parent NIAID U01, we are improving the HARI algorithm to assess radiation exposure using algorithmic approaches and Complete Blood Counts (CBC) with WBC differential. ASELL will investigate improved algorithm formats, incorporate time- and age-dependent factors to improve algorithm performance, and develop an in silico hematopoietic cell depletion model aligned with FDA feedback to supplement the limited availability of real-world human clinical data for evaluating performance of the algorithm.

PI_NAMEs: KOWALSKI, RICHARD JOSEPH (contact)

PROGRAM_OFFICER_NAME: VEDAMONY, MERRILINE M

PROJECT_TERMS: Acute;Address;Administrative Supplement;age related;Algorithms;Area;Award;biodosimetry;Biological Assay;Biological Markers;Blood Cells;Cell surface;Cells;Clinical;Clinical Data;Clinical Research;cohort;Complete Blood Count;Computer Models;Computer Simulation;Data;Data Sources;Detection;Development;Devices;Dose;emergency preparedness;Equation;extracellular;Feedback;Future;Goals;Hematopoietic;Human;human data;improved;in silico;mass casualty;Measurement;Medical Device;Modeling;National Institute of Allergy and Infectious Disease;Nuclear Accidents;parent project;Parents;Performance;point of care;Radiation;Radiation exposure;Radiation Injuries;Radiology Specialty;research and development;Source;Time;tool;Triage;Validation;virtual

PROJECT_TITLE: Research and Development of a Hand-held, Rapid, Point-of-Care Radiation Biodosimetry Triage Device and Integration of Soluble and Cell-surface Radiation Injury Biomarker Assays


ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: PROJECT NARATIVE Antibiotic resistance is an increasing problem especially in gram-negative bacteria where the permeability barrier created by the outer membrane (OM) excludes many antibiotics; yet, although a barrier, the pathways responsible for synthesizing and transporting OM components are potential targets for the development of antimicrobials that can weaken the OM. Our proposed study will investigate the biogenesis of a conserved component of the cell envelope of Enterobacterales, enterobacterial common antigen (ECA), which has functions in maintenance of the OM permeability barrier. The knowledge of ECA biogenesis gained through our work will facilitate functional studies of ECA and identify potential targets for antimicrobial small molecules.

PI_NAMEs: MITCHELL, ANGELA MARIE (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acute;Address;Anabolism;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Antigens;antimicrobial;aqueous;bile salts;Biochemical;Biochemical Reaction;Biogenesis;Biology;Carbohydrates;cell envelope;Cell Membrane Permeability;Cells;Cellular Structures;Cessation of life;Cyclization;Defect;Development;economic cost;Enteral;enterobacterial common antigen;Environment;Escherichia;Escherichia coli;Escherichia coli K12;Exclusion;experience;Feedback;Genes;Genetic;genetic analysis;Genetic Determinism;Genetic Screening;genetic selection;Genetic Transcription;Genomics;Goals;Gram-Negative Bacteria;Head;Hydrophobicity;improved;Infection;innovation;insight;interest;Investigation;Klebsiella;Knowledge;Length;Link;Lipids;Maintenance;member;Membrane;Mutation;Nature;novel;Nutrient;Pathogenicity;Pathway interactions;Peptidoglycan;Periodicity;periplasm;Permeability;Phenotype;Phospholipids;Physiological;Play;posttranscriptional;Production;Reaction;Regulation;Regulatory Pathway;response;Role;Salmonella;small molecule;Stress;Surface;Techniques;Transcription Regulation Pathway;United States;Work;Yersinia

PROJECT_TITLE: Biogenesis of cyclic and phospholipid-linked enterobacterial common antigen

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: The Northwestern University Medical Scientist Training Program prepares students for exciting and rewarding careers that combine biomedical investigation with the art of clinical medicine. Through an integrated, seven-to-eight year course of study, MSTP students develop the research, clinical, and professional skills required to pursue diverse career paths in the biomedical workforce, including positions in academia, industry, and federal agencies.

PI_NAMEs: HAUSER, ALAN R (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE A number of transformative advances have recently occurred at the intersection of type 1 diabetes (T1D) and biomedical engineering (BME), including the development of technology-based strategies for disease management as well as progress towards the first T1D immunotherapy, an effort currently under review by United States Food and Drug Administration (FDA). To address the rapidly growing need for individuals cross-trained in these arenas, we established this interdisciplinary graduate program to facilitate co-mentoring of pre-doctoral students in BME and T1D. Given our program’s 100% retention of graduates in science careers to date, alongside prioritization to those with underrepresented minority or disability designations, we are confident that the training environment supported by this T32 will continue to prepare the next generation of researchers for careers seeking to develop new strategies for the management, prevention and reversal of T1D.

PI_NAMEs: ATKINSON, MARK A. (contact);KESELOWSKY, BENJAMIN GEORGE

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Biomedical Engineering;Insulin-Dependent Diabetes Mellitus;programs

PROJECT_TITLE: Interdisciplinary Graduate Program in Type 1 Diabetes and Biomedical Engineering

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Monoclonal gammopathy of undetermined significance (MGUS) is a precancerous condition affecting ~3.5 million Americans. Other than active surveillance, there is no treatment to prevent MGUS from progressing into cancers, the vast majority of which are incurable. The proposed CAP-MGUS Center will be one of the few in the nation to facilitate the development of innovative agents against high-value targets in MGUS patients and thereby establish a foundational infrastructure to fast-track precision medicines for cancer prevention and interception.

PI_NAMEs: LI, YONG  (contact)

PROGRAM_OFFICER_NAME: VLAD, ANDA MIOARA

PROJECT_TERMS: Affect;Age Years;American;Amyloid;Automobile Driving;Blood;Bone Marrow;Bone Marrow Cells;Cancer Center;cancer diagnosis;cancer invasiveness;cancer prevention;cancer risk;Chemicals;Chemoprevention;Chronic Lymphocytic Leukemia;clinical practice;Communication;Consensus;Dedications;Development;Diagnosis;Diagnostic;Disease;DNA Vaccines;early phase clinical trial;efficacy evaluation;follow-up;Funding;Ganciclovir;Goals;Hematological Disease;high risk;IgE;Immunoglobulin A;Immunoglobulin D;Immunoglobulin G;Immunoglobulin M;Immunoglobulins;Immunologics;Immunoprevention;Immunotherapy;In Vitro;in vivo;Infrastructure;innovation;Intercept;Intervention;Investigation;Life Expectancy;Light;Light-Chain Immunoglobulins;Lymphoid;Malignant Neoplasms;Molecular;Monoclonal gammopathy of uncertain significance;Multiple Myeloma;multiple myeloma M Protein;Mutate;Network Infrastructure;Non-Hodgkin's Lymphoma;novel;Oncogenic;Oncoproteins;Patients;Persons;Plasmacytoma;Population;Population Control;Precancerous Conditions;precision cancer prevention;precision oncology;prevent;Prevention;Preventive;primary amyloidosis of light chain type;Process;programs;progression risk;Protein Secretion;Proteins;Recommendation;Research;research and development;Research Personnel;Research Project Grants;response;Risk;Risk Factors;Role;senescence;small molecule;Specialized Center;Syndrome;targeted agent;Testing;tumor initiation;tumor progression;tumor-immune system interactions;ubiquitin-protein ligase;Waldenstrom Macroglobulinemia

PROJECT_TITLE: DELINEATE THE TUMOR IMMUNE MICROENVIRONMENT FOR BETTER UNDERSTANDING IMMUNOTHERAPY RESPONSE


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Narrative Statement We propose continuation of M-CERSI that fosters FDA-oriented research, as well as regulatory science information sharing opportunities. The Center's mission is to foster the development of regulatory science – the science of developing new tools, standards and approaches to assess the safety, efficacy, quality and performance of FDA-regulated products. Activities leverage the close geographic proximity between University of Maryland and FDA's main campus.

PI_NAMEs: BENTLEY, WILLIAM E.;POLLI, JAMES E (contact)

PROGRAM_OFFICER_NAME: SEPULVEDA, KRISTIN

PROJECT_TITLE: University of Maryland Center of Excellence in Regulatory Science and Innovation


NIH_SPENDING_CATS: Lymphatic Research;Neurosciences

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Lymphatic dysfunction is closely related to major human diseases, including lymphedema, glaucoma, immune dysfunction, cancer, metabolic disease, and neurodegenerative disease. This project will decipher regulation of lymphatic endothelial cell junction and drainage, focusing on ROCK1/2 and integrin α5 signals by using a bioengineered 3D lymphatic vascular system in vitro and mouse inflammation and lymphedema models in vivo.

PI_NAMEs: LEE, ESAK  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: 3-Dimensional;Alzheimer's Disease;Animal Model;Architecture;Arthritis;Binding;Biological;Biology;Biomedical Engineering;Biophysics;Blood Vessels;Boston;Brain;Cell Culture Techniques;Cells;Clinical Research;Collaborations;Complex;Development;Dietary Fats;Disease;Drainage procedure;drug candidate;Exhibits;Experimental Models;Fibronectins;Fibrosis;Fluid Balance;Glaucoma;Goals;Homeostasis;Human;human disease;Immune System Diseases;Immunity;Immunologist;In Vitro;in vitro Model;in vivo;in vivo Model;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Intercellular Fluid;Intercellular Junctions;ITGA5 gene;lacteal;Ligands;Liquid substance;Lymph;lymph nodes;Lymphatic;Lymphatic Diseases;lymphatic drainage;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic Endothelium;Lymphatic function;Lymphatic System;lymphatic vessel;Lymphedema;Malignant Neoplasms;Mediating;Meningeal lymphatic system;Metabolic Diseases;Modeling;Morphogenesis;Morphology;Mus;Neurodegenerative Disorders;Neurons;Obesity;Organ;Outcome;Pediatric Hospitals;Pericytes;Permeability;Physiological;Protein Kinase;Regulation;Research Personnel;rho;ROCK1 gene;Role;screening;Signal Transduction;Small Intestines;Structure;therapeutic evaluation;three-dimensional modeling;Tissues;tool;Treatment Efficacy;two-dimensional;Universities;uptake;Vascular System;wasting

PROJECT_TITLE: Regulation of Lymphatic Endothelial Cell Junction and Drainage

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ORG_CITY: ARLINGTON

ORG_STATE: VA

PI_NAMEs: TEEL, OMARI  (contact)

PROJECT_TITLE: DIGITAL PLATFORM MAINTENANCE AND LIMITED ENHANCEMENT AND STRATEGIC DIGITAL PROGRAM MANAGEMENT


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: SILVER SPRING

ORG_NAME: SOCIAL AND SCIENTIFIC SYSTEMS,  INC.

PI_NAMEs: KOHRMAN, OLIVIA  (contact)

PROJECT_TERMS: Address;Adverse event;Case Report Form;Clinical;Clinical Research;Clinical Research Associate;clinical research site;Collaborations;Consent Forms;Contractor;Data;Data Analyses;Data Management Resources;diaries;electronic data;Electronic Mail;Ensure;expectation;follow-up;Human Resources;Institutional Review Boards;International;Laboratories;Letters;Location;Medical;Monitor;Names;National Institute of Environmental Health Sciences;Participant;Pharmaceutical Preparations;Phase;Procedures;Reporting;Research Contracts;Research Personnel;research study;Responsible Person;Roentgen Rays;Sampling;Schedule;Services;Site;Site Visit;Source;Specific qualifier value;Structure;Telephone;Time;timeline;tool;Training;Visit

PROJECT_TITLE: TASK ORDER 7R - CLINICAL MONITORING ACTIVITIES


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

ORG_STATE: CA

PHR: Two million men in the US have osteoporosis, and 600,000 men fracture annually due to their low bone mass. Osteoporosis is common in our male veterans. Despite those realities, men are rarely tested or treated for osteoporosis before fractures occur. Consequences of osteoporotic fractures are more severe in men than women. Hip fractures in men are particularly devastating. Mortality for a man with hip fracture is nearly 38% in the first year after that fracture. Although there are several drugs used to treat osteoporosis in women, far fewer therapies have been studied in men. We will test a new combination regimen that has potential to improve bone mass and structure in men. The regimen combines two drugs: one parathyroid hormone (1-34) and the other a drug that activates calcium-sensing receptors in bone cells. The overall goal is to stimulate bone formation and improve bone strength and ultimately to reduce fracture risk. These studies are essential first steps to for implementing better therapies for men with osteoporosis and high risk of fractures.

PI_NAMEs: SHOBACK, DOLORES M. (contact)

PROJECT_TERMS: Acute;Adult;Affect;Alendronate;American;Anabolic Agents;Biochemical;bisphosphonate;bone;bone cell;Bone Density;Bone Formation Stimulation;bone mass;bone metabolism;bone strength;Bone structure;bone turnover;Calcium;Calcium-Sensing Receptors;Cell Lineage;cell type;Cells;Chronic;cinacalcet;Clinical Trials;Collagen Type I;Combined Modality Therapy;Controlled Clinical Trials;Data;Death Rate;design;Diagnosis;disability;Double-Blind Method;double-blind placebo controlled trial;Drug usage;Estrogens;Excretory function;extracellular;Femur;follow-up;Forteo;Fracture;fracture risk;Goals;Health;high risk;Hip Fractures;Hip region structure;Hormonal;Hormone Receptor;Hour;Hyperparathyroidism;improved;Injections;insight;Lead;male;man;men;Mesenchymal Stem Cells;microCT;mineralization;Morbidity - disease rate;mortality;Mus;N-terminal;Neck;Normal Range;novel;optimal treatments;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;Osteoporotic;Parathyroid gland;parathyroid hormone (1-34);parathyroid hormone-related protein;peptide hormone;Pharmaceutical Preparations;Pharmacodynamics;Physiological;Placebo Control;Placebos;Plasma;Play;Postmenopause;pre-clinical;Pre-Clinical Model;primary endpoint;PTH gene;Randomized;Rattus;receptor;Receptor Activation;Recombinants;recruit;Regimen;response;Risedronate;Role;Safety;screening;Serum;Serum Markers;skeletal;targeted treatment;Testing;Toxicology;treatment arm;treatment comparison;Treatment Protocols;treatment strategy;urinary;Vertebral column;Veterans;Woman;women versus men;Women's mortality;Women's trial;Work

PROJECT_TITLE: Novel Combination Therapy for Osteoporosis in Men

STUDY_SECTION: ENDB

STUDY_SECTION_NAME: Endocrinology B[ENDB]


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Obstructive sleep apnea (OSA) is common in Veterans, affecting 47% of those with a diagnosed sleep disorder. OSA treatment improves health, and positive airway pressure (PAP), the mainstay of OSA therapy, is effective. However, adherence to PAP is low: 24% of patients stop therapy within 3 months and another 23% stop use by 1 year. This project seeks to identify and validate breathing patterning metrics from sleep study and PAP machine respiratory signals as adherence predictors. By repurposing respiratory signals obtained during routine clinical care, this project would allow for targeting of interventions to improve adherence in Veterans that would most benefit – those most likely to become nonadherent. Since no new equipment or testing is necessary, this project has the potential for streamlined integration into clinical care, saving time for Veterans and increasing VA healthcare efficiency.

PI_NAMEs: MAY, ANNA MICHELLE (contact)

PROJECT_TERMS: Adherence;Affect;Age;age effect;age related changes;Air Movements;awake;Award;Behavioral;Biomedical Engineering;Breathing;career;career development;Characteristics;Clinical;clinical application;clinical care;Clinical Data;Clinical Informatics;clinical practice;Communities;comorbidity;Complement;Complex;Computerized Medical Record;cost effective;Cost Savings;Data;Data Collection;data management;Data Science;Databases;demographics;design;Development;Devices;Diagnosis;Discrimination;Equipment;Evaluation;experience;follow-up;Foundations;Functional disorder;Funding;Goals;Health;health care service utilization;Healthcare;Healthcare Systems;high risk;Home;improved;indexing;Individual;innovation;Instruction;interest;Intervention;Leadership;Life;Link;Location;Machine Learning;machine learning algorithm;Measures;Medical History;Medicine;meetings;Mental Health;Mentors;Methods;model development;Modeling;Modernization;Monitor;mortality;multidisciplinary;multimodality;Obstructive Sleep Apnea;Outpatients;patient oriented;Patients;Pattern;Performance;Persons;physical conditioning;Physiological;Plethysmography;Polysomnography;positive airway pressure;predictive modeling;Procedures;Provider;Public Health Informatics;Qualifying;Records;Research;research and development;Research Personnel;respiratory;Respiratory physiology;responsible research conduct;Risk;signal processing;Signal Transduction;skills;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Sleep Disorders Therapy;Sleep Stages;Solid;Staging;System;Techniques;Testing;therapy adherence;Tidal Volume;Time;Training;Translating;translational study;Translations;Validation;Variant;Veterans

PROJECT_TITLE: Breathing patterning in obstructive sleep apnea


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: Parkinson's disease (PD) is a neurodegenerative disorder with motor symptoms that affects about 1 million people in the United States, with about 60,000 new cases every year. The Department of Veterans Affairs (VA) has recognized the link between PD and herbicides, such as Agent Orange, which many veterans have been exposed to. Consequently, treatment of PD is of major importance to the VA. An increase in impulsivity–and associated impulse control disorders–has been identified in recent years as a major potential complication of PD. The goal of the project is to investigate the patterns of neural oscillatory activity associated with impulse control in PD patients and how they are affected by the use of dopamine agonists. Subjects will be assessed using magnetoencephalography while they perform in tasks that probe two main dimensions of impulsivity– motor impulsivity and decision-making impulsivity. The outcome will provide new information about the pathophysiology of impulse control disorders in PD, which will help to advance treatment by medication.

PI_NAMEs: LEWIS, SCOTT M;PELLIZZER, GIUSEPPE  (contact)

PROJECT_TERMS: Affect;Age;agent orange;behavior test;Behavioral;behavioral outcome;Binge Eating;Biological Markers;Brain;care burden;Caregivers;Caring;Cephalic;Complication;Data;Decision Making;Deep Brain Stimulation;design;Deterioration;Development;Dimensions;Distress;Dopamine;Dopamine Agonists;dopamine replacement therapy;Effectiveness;Electrophysiology (science);Excision;experience;Exposure to;fall risk;Family;Functional disorder;Future;Gambling;Ganglia;General Population;Goals;Herbicides;improved;Impulse Control Disorders;Impulsive Behavior;Impulsivity;Individual;individualized medicine;Intervention;Iowa;Levodopa;Link;Magnetoencephalography;Measures;Methodology;Modeling;Morbidity - disease rate;Motor;motor symptom;neural;neural network;neural patterning;Neurodegenerative Disorders;neuromechanism;neurophysiology;neuroregulation;Outcome;Parkinson Disease;Pathologic;Pathological Gambling;Patient Care;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Predisposition;prospective;Quality of life;Questionnaires;Recurrence;Research;Research Design;response;Risk;Sampling;Source;spatiotemporal;Substance Withdrawal Syndrome;temporal measurement;treatment response;two-dimensional;United States;United States Department of Veterans Affairs;Veterans;Well in self

PROJECT_TITLE: Biomarkers of Impulsivity in Parkinson's Disease