NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Radiation Oncology;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Radiation-induced vaginal toxicity is a common side effect of pelvic radiotherapy, and no clinical tools exist for objective, quantitative evaluation of vagina health. The goal of this research project is to develop a system and methodology for multiparametric ultrasound-based assessment of vaginal toxicity in the acute and late stages following radiotherapy.

PI_NAMEs: BURGESS, MARK THOMAS (contact)

PROGRAM_OFFICER_NAME: SAMIMI, GOLI

PROJECT_TERMS: 3-Dimensional;Acute;Adjuvant;Affect;Anatomy;Awareness;Biological;Biological Markers;Blood flow;Blood Vessels;Calibration;Cancer Patient;cancer recurrence;Cell Death;Cessation of life;chemotherapy;Chronic;Clinical;Clinical assessments;clinical practice;Clinical Research;Clinical Treatment;Collagen;Conformal Radiotherapy;Connective Tissue;cost effective;Custom;Data;debilitating pain;Deposition;Development;Elastic Fiber;Elastin;elastography;Endometrial Carcinoma;Epithelium;Fibrosis;Fire - disasters;Funding Opportunities;Goals;Gynecologic;Gynecologic Brachytherapy;Health;Hypoxia;Image;imaging approach;imaging biomarker;imaging platform;Imaging technology;improved;Individual;Inflammation;Intervention;Late Effects;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measurement;Measures;Mechanics;Medical Imaging;Methodology;Methods;multimodality;multiparametric imaging;novel;Operative Surgical Procedures;Outcome;Pain;Patient Outcomes Assessments;patient stratification;Patients;Pelvis;Perception;Phase;Physical Examination;Population;Postoperative Period;prevent;Procedures;Property;Quality of life;Quantitative Evaluations;quantitative ultrasound;Radiation;Radiation Dose Unit;radiation effect;radiation response;Radiation therapy;Reporting;Research;Research Project Grants;Risk;Role;Rotation;Sample Size;Screening for cancer;secondary analysis;Sex Functioning;Sexual Dysfunction;Side;side effect;standard of care;statistics;Stenosis;Structure;Symptoms;System;Testing;Thick;Three-Dimensional Imaging;Time;Tissues;tool;Toxic effect;Translations;Transvaginal Ultrasound;treatment planning;treatment strategy;Ultrasonography;ultrasound;Vagina;Variant;Woman;Women's Health

PROJECT_TITLE: Clinical assessment of radiotherapy-induced vaginal toxicity with multiparametric ultrasound imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-J (96)]


ADMINISTERING_IC: AT

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Health Services;Mental Health;Patient Safety;Prevention

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: FAMILY MEDICINE

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Burnout is pervasive in oncology, imparting harm to both providers and patients, increasing healthcare and workforce disparities, and exacerbating projected physician and nursing shortages. To address the critical and unmet need for evidence-based, acceptable, and scalable interventions to improve burnout, this application will evaluate the feasibility and acceptability of a novel team-based intervention that includes mindfulness and compassion-based approaches and is delivered by hospital chaplains embedded within the interprofessional team. It will also develop and validate a low-burden, objective, and embedded ambulatory assessment “toolkit” to identify interpersonal and objective behavioral indices that can be used to improve research rigor and ultimately expand the evidence-base for effective approaches to improve provider well-being and address the needs of the 21st century healthcare workforce.

PI_NAMEs: MASCARO, JENNIFER STREIFFER (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: acceptability and feasibility;Acoustics;Address;Behavioral;burnout;cancer therapy;Cessation of life;Chaplain;Chronic Disease;Clinic;Clinical Oncology;Clinical Services;Collaborations;Compassion;Comprehensive Cancer Center;Consolidated Framework for Implementation Research;Consultations;cost;COVID-19 pandemic;Data;Discipline of Nursing;Disparity;Ecological momentary assessment;effectiveness evaluation;Elements;Emotional;Employee;Enrollment;Environment;Equity;evidence base;exhaustion;Feasibility Studies;Feeling;Feeling suicidal;Focus Groups;follow-up;Fostering;Frequencies;Goals;Health;Health Personnel;Healthcare;help-seeking behavior;high risk;Hospitals;improved;indexing;Individual;innovation;Intervention;Measurement;Measures;Medical Care Team;Medical Errors;member;Mental Depression;Methodology;Methods;microaggression;mindfulness;novel;Nurses;Oncology;Pain;Participant;participant enrollment;patient safety;Patient Self-Report;Patients;peer;Personal Satisfaction;Phase;Physicians;Pilot Projects;post intervention;prevent;Prevention;preventive intervention;Process;professional atmosphere;Provider;psychologic;Psychosocial Assessment and Care;Randomized;recruit;Religion;Research;resilience;retention rate;Risk;Role;Safety;Sampling;satisfaction;side effect;social;Social support;Spiritual care;Spirituality;stressor;Substance abuse problem;success;Surveys;Training;treatment planning;Waiting Lists;Work;Workload

PROJECT_TITLE: Feasibility study of a chaplain-delivered compassion intervention to improve  psychological safety among interprofessional healthcare teams

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 BH (01)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Primary Health Care;Social Determinants of Health;Suicide;Suicide Prevention;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Narrative In Tajikistan, as well as in many other LMICs, especially in Asia, women have elevated rates of suicide. This project works collaboratively with diverse stakeholders to develop and pilot a scalable evidence-based nurse and peer-led suicide prevention program in primary care for women at moderate or high risk for suicide. It could help reduce the epidemic of suicide and it also augments an NIH supported research capacity building program to further advance the implementation science capacities of mental health researchers in Tajikistan.

PI_NAMEs: PIROVA, GULCHEKHRA ;WEINE, STEVAN MERRILL (contact)

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Address;Adult;age group;Asia;Award;Behavior Therapy;Care given by nurses;Caring;Cause of Death;Central Asia;Chicago;Collaborations;Communities;cost;Country;design;Education;Effectiveness;Epidemic;Equity;Evaluation;evidence base;Family Practice;Feeling suicidal;Fostering;Funding;Future;Goals;Health;health goals;Healthcare Systems;high risk;Human Resources;Hybrids;Illinois;implementation evaluation;implementation outcomes;implementation process;implementation science;implementation/effectiveness;Individual;Institution;Intervention;Investigation;Knowledge;Labor Migrations;longitudinal design;low and middle-income countries;Mediator;men;Mental disorders;Mental Health;Mental Health Services;Mentorship;Methods;migration;Modeling;National Institute of Mental Health;novel;Nurses;Outcome;peer;Persons;pilot test;Play;Policies;pragmatic trial;Prevention;Prevention program;Primary Care;primary care clinic;Primary Health Care;prisma;Process;programs;protective factors;Provider;Randomized;Reduce health disparities;reducing suicide;Research;Research Activity;Research Personnel;Research Support;Risk Factors;Role;Rural;scale up;skills;socioeconomics;Strategic Planning;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Tajikistan;Testing;Training;treatment as usual;Unemployment;United States National Institutes of Health;United States Public Health Service;Universities;violence exposure;War;Woman;Women's Health Services;women's prevention;Work

PROJECT_TITLE: Nurse and Peer Led Suicide Prevention in Tajikistan

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-C (01)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE The alphavirus Mayaro is a mosquito borne pathogen that causes febrile illness in Latin America but has not produced widespread outbreaks like related chikungunya virus. Given that chikungunya epidemics are promoted by viral adaptation to increase infection and transmission in urban mosquito species, the goal of this project is to assess the potential for Mayaro virus to adapt to urban mosquito vectors using an experimental evolution approach. Understanding potential for Mayaro virus adaptation is important for defining risk of future outbreaks.

PI_NAMEs: COFFEY, LARK L (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Aedes;Alpha Virus;Arboviruses;Arthralgia;Biological Assay;Blood;chikungunya;Chikungunya virus;Cities;Clinical;co-infection;cohort;Country;Culicidae;deep sequencing;Disease;Disease Outbreaks;Dose;Epidemic;epidemic virus;Epidemiology;Evolution;Exposure to;Fever;fitness;forest;Future;future outbreak;Gene Mutation;Genes;Genomics;Goals;Human;human disease;human pathogen;in vivo;Individual;Infection;Ingestion;Knowledge;Laboratories;Latin America;Mayaro virus;Measures;Mediating;mosquito-borne;mosquito-borne pathogen;Mus;mutant;Mutation;Nature;novel;oral infection;Oral Ingestion;outbreak prediction;Periodicals;Persons;Phenotype;Predisposition;prevent;previous outbreak;Probability;Risk;Serial Passage;Series;Source;Testing;transmission process;vaccine candidate;vaccine development;vector;vector competence;vector mosquito;Venezuelan Equine Encephalitis Virus;Vertebrates;Viral;Viremia;Virus;Virus Diseases;Work

PROJECT_TITLE: Adaptation of Mayaro virus to urban mosquitoes

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: The goal of this study is to identify new brain circuits that are causally involved in symptoms of mental illness. These circuits can then be used as treatment targets for brain stimulation, a technique that can be used as a treatment for various mental illnesses.

PI_NAMEs: SIDDIQI, SHAN  (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Acceleration;Address;anti-depressive agents;Anxiety;anxiety sensitivity;Aptitude;Atlases;Behavior;Behavioral;Brain;brain circuitry;Brain imaging;Brain Mapping;Brain region;Clinical;clinical application;Clinical Trials;Cognitive;conflict resolution;connectome;conventional therapy;Data;Decision Making;Diagnosis;Diagnostic;Dimensions;Dose;Emotional;Etiology;Extinction;flexibility;Foundations;Fright;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Generalized Anxiety Disorder;Goals;Grain;Human;improved;Individual;inter-individual variation;Left;Lesion;Location;Major Depressive Disorder;Maps;Meaning and purpose;Measurement;Measures;Mediating;Mental Depression;Mental disorders;Mental Health;Methods;Morals;motor rehabilitation;N-Methylaspartate;Nature;negative affect;Nervous System Physiology;neuroimaging;Neurotransmitters;Obsessive compulsive behavior;Obsessive-Compulsive Disorder;Outcome;Participant;Patient Self-Report;Patients;Personality;Personality Traits;Phenotype;Prefrontal Cortex;Process;prospective;Protocols documentation;Psychiatry;psychologic;Publishing;Randomized;rapid growth;Research Personnel;response;Rest;Role;Sampling;Scalp structure;Schizophrenia;Site;social;symptom cluster;Symptoms;Techniques;Technology;Temperament;Testing;Time;trait;Transcranial magnetic stimulation

PROJECT_TITLE: A causal wiring diagram of transdiagnostic brain functions

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-G (01)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE South Asia has the highest suicide rate in the world with important risk profile differences from high-income settings. We will conduct formative research to co-design a package of brief interventions and implementation strategies to prevent youth-suicide and then test the package in a pilot feasibility hybrid type 2 cluster randomized controlled trial in Nepal. Potential health impacts may be substantial as results can be applied not only in similar South Asian primary healthcare contexts, but also in low-resource settings in the US and abroad, where the suicide burden remains high.

PI_NAMEs: HAGAMAN, ASHLEY K (contact);SHRESTHA, ARCHANA

PROJECT_TERMS: Accident and Emergency department;Address;Adolescent;adolescent mental health;Adoption;Adult;Advocate;Age;Age Years;American;Asia;Behavior Disorders;Benchmarking;brief intervention;Caring;Cause of Death;Cessation of life;Child;Clinical;Clinical Pathways;Clinical Trials;Cluster randomized trial;Collaborations;Communities;community advisory board;coping;cost effective;Counseling;Country;design;Detection;Economics;Education;Effectiveness;Elements;Emergency Situation;Enrollment;Equity;ethnic minority;evidence base;Evidence based intervention;Family;Family member;family structure;Feeling hopeless;Feeling suicidal;Female;follow-up;Foundations;Fright;Future;Gender;gender disparity;Geography;Health;Health care facility;health organization;health service use;Health Services;Health system;high risk population;Hospitals;Hybrids;implementation framework;implementation outcomes;implementation strategy;implementation study;improved;Income;Indigenous;Individual;Inequity;innovation;Intervention;Lived experience;low and middle-income countries;male;Manuals;marginalization;Measures;Mediator;medical schools;Mental disorders;Mental Health;Mental Health Services;Methods;Municipalities;Nepal;Nongovernmental Organizations;novel;Outcome;peer;peer networks;peer support;Persons;pilot test;pilot trial;Play;Politics;Poverty;Preparation;prevent;Prevention;Prevention strategy;preventive intervention;primary care clinician;Primary Health Care;programs;Psychiatry;Public Health;public health intervention;Randomized;Randomized, Controlled Trials;Recording of previous events;reducing suicide;reproductive;Research;Resource-limited setting;Resources;response;Risk;Role;Rural;rural area;Safety;scale up;Science;Screening procedure;service uptake;Severities;social;social stigma;South Asian;Specialist;success;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Supervision;System;teacher;Testing;theories;Theory of Change;Training;Training Programs;treatment as usual;Trust;Universities;volunteer;Vulnerable Populations;Women's mortality;Work;young woman;Youth

PROJECT_TITLE: Innovations for peer-delivered and family-engaged brief interventions for youth suicide in Nepal: A pilot hybrid type 2 implementation study


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Worldwide, the more than 52% of women living with HIV (WLWH) experience earlier onset of non-AIDS comorbidities (such as diabetes and heart disease) and increased mortality compared to men living with HIV (MLWH), despite viral suppression with antiretroviral therapy. The underlying cause for this difference is likely increased HIV-induced immune activation and inflammation in WLWH compared to MLWH. The goal of this proposal is to demonstrate that CD38, a T cell marker of immune activation in HIV infection, plays a role in chronic inflammation in WLWH and is a potential therapeutic target to decrease morbidity and mortality in WLWH.

PI_NAMEs: MATHUR, POONAM  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Adult;Affect;Age;antiretroviral therapy;Attenuated;Biological;Blood specimen;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Chronic;comorbidity;cytokine;Data;Diabetes Mellitus;Disease Outcome;Disease Progression;early experience;early onset;Enzymes;experience;Female;genetic signature;Goals;Heart Diseases;high risk;HIV;HIV Infections;HIV Seronegativity;Immune;immune activation;immunodeficiency;Immunologic Markers;Immunologics;In Vitro;in vivo;Inflammation;Inflammatory;Interferon Type II;Interleukin 2 Receptor Gamma;Life Expectancy;male;Measures;men;Modeling;Morbidity - disease rate;mortality;Mus;Nicotinamide adenine dinucleotide;nicotinamide riboside supplementation;nicotinamide-beta-riboside;Pathogenesis;Peripheral Blood Mononuclear Cell;Play;Production;Publishing;Randomized, Controlled Trials;Research;response;Role;Sampling;Severe Combined Immunodeficiency;sex;Sex Differences;Strategic Planning;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;transcriptome sequencing;Viral;Viral Pathogenesis;Woman;women's morbidity;Women's mortality

PROJECT_TITLE: CD38 intensifies immune activation in women living with HIV (the CIGNAL study)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (95)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_STATE: NY

PHR: An unmet clinical need exists for new therapeutic concepts in pancreatic ductal adenocarcinoma (PDAC), a cancer associated with exceptionally high mortality. We hypothesize that intra-tumoral heterogeneity, progression, metastasis, and drug resistance is driven by hypoxia-mediated reprogramming of PDAC cells. In this study we interrogate the function of hypoxic cells and identify molecular mechanisms that drive adaptation to hypoxia in PDAC tumors in vivo, which may inform future therapeutic strategies.

PI_NAMEs: HEMANN, MICHAEL ;TAMMELA, TUOMAS  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Aggressive behavior;Automobile Driving;Biological;Biology;Blood Vessels;Body part;cancer cell;cancer therapy;candidate marker;Cell Cycle;Cell Hypoxia;Cells;Chemoresistance;chemotherapy;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;Coupled;CRISPR/Cas technology;Data;Dependence;Diagnosis;Distant;DNA Methylation;Drug resistance;epigenetic memory;experience;experimental study;Exposure to;Future;Gene Expression;Gene Expression Profiling;Generations;Genes;Genetic;Genetic Screening;Genetic Transcription;Genetically Engineered Mouse;Growth;Heterogeneity;histone modification;Human;Hypoxia;Hypoxia Pathway;Immunotherapy;improved;In Situ;in vivo;innovation;Investigation;KRAS2 gene;Link;Longitudinal Studies;Maintenance;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Memory;Messenger RNA;Metabolic;Molecular;mortality;Mus;Neoplasm Metastasis;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;Oxygen;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Phase;Phenotype;Population;Process;programs;Property;Protein-Serine-Threonine Kinases;Proteins;receptor;recombinase;Recording of previous events;Reporter;Research;Resistance;Resolution;response;Role;side effect;Signal Pathway;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;small hairpin RNA;Solid Neoplasm;stemness;System;targeted treatment;Therapeutic;Therapeutic Intervention;Tissues;transcriptome;Treatment Failure;treatment response;tumor;tumor growth;tumor heterogeneity;tumor progression;Tumor Promotion

PROJECT_TITLE: Investigating hypoxia as a determinant of malignant fates in pancreas cancer

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Nutrition;Obesity;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PUBLIC HEALTH NARRATIVE Older Hispanic/Latina women living with food insecurity are at very high risk for medical conditions; despite this, they have been understudied in medical research. Chronic binge eating disorder (BED) worsens risk for multimorbidity and may be particularly detrimental for older Hispanic/Latina women living with food insecurity. This study will provide critical information about the prospective impacts of BED in older Hispanic/Latina women living with food insecurity that can be used to inform future treatment efforts and policy changes.

PI_NAMEs: BECKER, CAROLYN BLACK;KILPELA, LISA  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Affect;aged;Area;Binge Eating;Binge eating disorder;Biomedical Research;Body mass index;cardiometabolic risk;cardiometabolism;Caucasians;Characteristics;Chronic;Clinical;community engaged research;Data;Data Collection;depressive symptoms;design;disadvantaged women;Disease;Disparity;Eating;Eating Disorders;economic determinant;economic disparity;Enrollment;Environmental Risk Factor;ethnic minority population;Event;experience;Feeling;Food;food insecurity;Frequencies;Future;Glycosylated hemoglobin A;Goals;Health;Health Personnel;health related quality of life;healthspan;high risk;Hispanic;human old age (65+);Hunger;improved;indexing;Individual;Intervention;late life;Latina;Latino;Life;Lipids;Lived experience;Mediator;Medical;Medical Research;men;Menopause;Mental Depression;Mental Health;Methods;middle age;Modeling;Morbidity - disease rate;multidisciplinary;multiple chronic conditions;Nature;Not Hispanic or Latino;novel;Obesity;older women;Outcome;Overweight;Participant;Physical Function;Policies;Population;Prevalence;primary outcome;programs;prospective;Prospective Studies;Psyche structure;psychosocial;Public Health;Quality of life;Recording of previous events;recruit;Reporting;Research;Research Personnel;Risk;Sampling;sarcopenic obesity;secondary outcome;Seminal;Services;Severities;Sleep Disorders;social health determinants;socioeconomics;Stereotyping;stressor;treatment research;underserved community;Woman;women's morbidity;Work;Youth

PROJECT_TITLE: Prospective Health Impacts of Chronic Binge Eating Disorder in Hispanic Older Women Living with Food Insecurity (PROSPERA)


NIH_SPENDING_CATS: Breast Cancer;Cancer;Dietary Supplements;Genetics;Nutrition;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative The proposed project aims to develop a novel therapeutic strategy that combines high doses of two vitamins, folate and vitamin C, to selectively kill BRCA1/2-deficient tumors by generating metabolic toxins in cancer cells. The findings from this research could rapidly progress to clinical trials and validate an unconventional approach of harnessing metabolism for cancer therapy.

PI_NAMEs: BLENIS, JOHN  (contact);BURGOS-BARRAGAN, GUILLERMO

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: anticancer activity;Ascorbic Acid;Biological Assay;Blood;Body Weight decreased;BRCA deficient;brca gene;BRCA1 gene;BRCA2 gene;Breast;Breast Cancer Patient;cancer cell;Cancer Model;cancer therapy;Carboplatin;cell killing;Cell Line;Cells;Cellular biology;checkpoint therapy;Circulation;Clinical Trials;crosslink;Crosslinker;cytotoxic;cytotoxicity;Data;Disease;DNA;DNA Adducts;DNA analysis;DNA crosslink;DNA Damage;DNA lesion;DNA Repair;Dose;Drug Kinetics;efficacy evaluation;efficacy study;Folic Acid;Formaldehyde;Foundations;Generations;Goals;Half-Life;Immunohistochemistry;In Vitro;in vivo;infrared microscopy;Kidney;kidney dysfunction;Lead;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Manipulative Therapies;Mass Spectrum Analysis;Maximum Tolerated Dose;Measures;Metabolic;Metabolism;metabolomics;Methods;Modeling;Molecular Biology;Mus;Mutagens;mutant;Mutate;new therapeutic target;Normal tissue morphology;novel;novel therapeutic intervention;Ovarian;oxidation;Patients;Pharmacodynamics;Play;Poison;Pre-Clinical Model;Property;Reactive Oxygen Species;renal damage;repaired;Research;Role;standard of care;stem;synergism;Techniques;Testing;Tetrahydrofolates;Therapeutic;tool;Toxic effect;Toxin;Treatment Efficacy;treatment strategy;tumor;tumor growth;tumor metabolism;Tumor Suppressor Genes;Vitamins

PROJECT_TITLE: Targeting BRCA1/2-deficient cancers with folate and vitamin C

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-O (J1)]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: Project Narrative. Black school-age children report suicidal thoughts and behavior (STB) more frequently than their white peers and are twice as likely to die from suicide. The most common psychiatric disorder associated with STB and suicide deaths in school-age Black children is attention-deficit/hyperactivity disorder (ADHD), and Black children may experience a disproportionate impact from ADHD-related risk for STB due to racism. There is a need for research examining how ADHD may intersect with racism to widen the racial disparity in STB and suicide deaths, and which factors could protect against STB, to inform suicide prevention strategies for Black school-age children with ADHD.

PI_NAMEs: SPENCER, ANDREA  (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: 11 year old;Accounting;Advisory Committees;Age;aged;Attention deficit hyperactivity disorder;Black race;Censuses;Chicago;Child;Child Health;Clinical;Clinical Research;clinical risk;cohort;Cohort Analysis;Conflict (Psychology);Congresses;Data;Development;Discrimination;Education;educational atmosphere;Emergency Situation;emotion dysregulation;ethnic minority;experience;Face;Failure;Family;Family Relationship;Feeling suicidal;Funding;Future;Goals;health disparity;high risk;high risk population;Illinois;improved;Impulsivity;indexing;Intercept;intersectionality;Interview;Longitudinal cohort;Longitudinal cohort study;Medicaid;Mental disorders;Methods;middle childhood;minority children;Modeling;National Institute of Mental Health;Neighborhood Health Center;Parents;Pediatric Hospitals;peer;perceived discrimination;Pharmaceutical Preparations;Population;Positioning Attribute;Prevention strategy;preventive intervention;primary outcome;Principal Investigator;prospective;Prospective, cohort study;protective factors;Provider;Proxy;psychiatric comorbidity;Qualitative Methods;racial disparity;racial minority;racism;recruit;Reporting;Research;Research Personnel;Resources;Risk;Risk Factors;risk mitigation;Risk Reduction;Sampling;School-Age Population;Schools;Severities;Shapes;Social Environment;Structural Racism;Structure;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;suicide model;Suicide prevention;suicide rate;System;therapy development;Time;time use;Visit;Work;Youth

PROJECT_TITLE: Understanding the multilevel impact of racism on suicidal thoughts and behaviors among Black children with ADHD: Intersectionality, Risk, and Protective Factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (02)]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Estrogen;Menopause;Regenerative Medicine;Urologic Diseases;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Genitourinary syndrome of menopause and the associated condition of vulvovaginal atrophy negatively impacts the quality of life of millions of perimenopausal and menopausal women world-wide. Despite its high prevalence and interference with healthy aging, current treatments for GSM are suboptimal, with many issues related to accessibility or long-term efficacy. The proposed research will determine if a minimally invasive, low-cost, acellular biomaterial with modular delivery mechanism can reverse pathological changes in all vaginal tissue layers and therefore restore a healthy vaginal phenotype.

PI_NAMEs: ALPERIN, MARIANNA  (contact);CHRISTMAN, KAREN L

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Affect;Age;Animal Model;Animals;Anterior;Apoptosis;Atrophic;Biochemical;Biocompatible Materials;biomaterial compatibility;Biomechanics;Cell Differentiation process;Cell Proliferation;Chromosome Mapping;Chronic;Clinical;cohort;Collagen;cost;Data;deprivation;design;Deterioration;Development;Elastic Tissue;Elasticity;Epithelial Cell Proliferation;Epithelium;Esthesia;Estrogens;Extracellular Matrix;Gene Expression;Genitourinary system;Growth;Harvest;healthy aging;High Prevalence;Hydrogels;Immune response;Immunohistochemistry;immunoregulation;Impairment;improved;In Situ;in vivo;Inflammatory Infiltrate;Injectable;Injections;innovation;Intervention;Lamina Propria;Low-Level Laser Therapy;Lubricants;mechanical properties;Menopausal Syndrome;Menopause;Metabolism;minimally invasive;multidisciplinary;Muscular Atrophy;neovascularization;novel;Ovariectomy;Pain;Pathologic;Pathway interactions;Perimenopause;Phenotype;Pre-Clinical Model;Premenopause;prevent;Proliferating;Property;Pruritus;Public Health;Quality of life;reduce symptoms;regenerative;regenerative therapy;regenerative tissue;repaired;Research;Safety;Saline;satisfaction;Selective Estrogen Receptor Modulators;Sex Functioning;side effect;Skeletal Muscle;Smooth Muscle;Sprague-Dawley Rats;success;Symptoms;Testing;Therapeutic;Thick;Thinness;Time;tissue regeneration;Tissues;tool;Topical application;transcriptomics;Treatment Efficacy;Up-Regulation;urogenital tract;Vagina;vaginal dryness;Vaginal Route of Drug Administration;Vascularization;Woman;Women's Health

PROJECT_TITLE: Regenerative biomaterial for combating genitourinary syndrome of menopause


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative This proposal will investigate the mechanisms by which non-sense mediated decay (NMD) is upregulated in clear cell kidney cancer as well as if triggering NMD can promote enhanced response to immune checkpoint inhibition.

PI_NAMEs: DOMINGUEZ, DANIEL ISSAC;KIM, WILLIAM Y. (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Allogenic;anti-PD1 antibodies;anti-PD1 therapy;Antibody Therapy;Antigens;cancer subtypes;Cell Line;Cessation of life;checkpoint inhibition;checkpoint therapy;Chemicals;Chemotherapy and/or radiation;Clear Cell;Clear cell renal cell carcinoma;Clinical;Clinical Data;Collaborations;Data;Data Set;Disease;Dose;Endogenous Retroviruses;Excision;FDA approved;FRAP1 gene;Gene Silencing;genetic approach;Genetic Suppression;Hypoxia;Immune;immune cell infiltrate;immune checkpoint blockade;Immune response;Immunotherapy;improved;in vivo;Individual;Inflammation;inhibitor;Interferons;Interleukin-2;Introns;KDR gene;Link;Literature;Malignant Neoplasms;Measurement;Melanoma;Messenger RNA;Modeling;mouse model;mTOR inhibition;mTOR Inhibitor;Mus;Mutation;neoantigens;Neoplasm Metastasis;Nonsense-Mediated Decay;Operative Surgical Procedures;Pathway interactions;Patients;Peptides;pharmacologic;Phenotype;Play;premature;programmed cell death protein 1;Proteomics;Radiation therapy;Recording of previous events;Recurrence;Regulation;Renal Carcinoma;Renal Cell Carcinoma;Resistance;response;RNA;RNA Decay;RNA Processing;Sampling;Secondary to;Signal Transduction;sound;Source;Specificity;Stem cell transplant;success;T-cell inflamed;Terminator Codon;Testing;The Cancer Genome Atlas;therapeutically effective;Transcript;transcriptome;translatome;tumor;Tumor Antigens;tumor growth;tumor initiation;tumor-immune system interactions;tumorigenesis;Tumorigenicity;Tyrosine Kinase Inhibitor;urologic;Work

PROJECT_TITLE: Triggering Aberrant RNA Processing for RCC Therapy

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE Extensive changes occur due to menopause that can put women at greater risk for heart attacks, diabetes, and related diseases, but the reasons why are not well understood. Here we propose to use a chemical that is toxic to follicles in mouse ovaries to simulate menopause, compare to control female and male mice, look at how genes are turned off and on in various organs throughout the body, and investigate how estrogen treatment reverses these changes. Together with comparisons between samples from premenopausal versus postmenopausal women, these findings could identify genes that change with menopause, facilitating more precise prevention and intervention strategies for cardiovascular disease in midlife women.

PI_NAMEs: THEUSCH, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: 4-vinylcyclohexene diepoxide;Adipose tissue;Age;Aging;aging gene;Androgens;Aorta;Automobile Driving;blood lipid;Blood Pressure;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Chemicals;Cholesterol;Chromatin;Clinical;comparison control;Coronary heart disease;Data;Data Set;Diabetes Mellitus;Disease;disorder risk;Elements;Endocrine;Estradiol;Estrogen Therapy;Estrogens;Estrous Cycle;experience;experimental study;falls;Female;Framingham Heart Study;Future;Gene Expression;Gene Expression Regulation;Genes;heart disease risk;Hormonal;Hormonal Change;hormone therapy;Hormones;Human;human data;human tissue;Implant;interest;Intervention;Investigation;Liver;male;Measures;Menopausal Status;Menopause;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;metabolomics;Midlife women;Molecular;Molecular Target;mortality;mortality risk;Motion;mouse model;Multiomic Data;Mus;Myocardial Infarction;Obesity;Organ;Ovarian;ovarian failure;Ovarian Follicle;Ovary;Participant;Perimenopause;Phenotype;Physiological;Placebos;Plasma;Play;post stroke;Postmenopause;Premenopause;Prevalence;Prevention strategy;Proteins;Proteomics;Risk;Risk Factors;Role;Sampling;Scientist;sexual dimorphism;steroid hormone receptor;stroke risk;Supplementation;Testing;Time;Tissues;transcription factor;transcriptome sequencing;transcriptomics;treatment duration;Tube;Twin Multiple Birth;Visceral fat;Woman;women subjects;Women's Health;Women's study;women's treatment

PROJECT_TITLE: Changes in cardiometabolic tissue gene regulation and omics profiles with menopause


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: NARRATIVE AD is characterized by the accumulation in the brain of misfolded protein aggregates in the form of amyloid-beta and hyperphosphorylated Tau. Toxic Tau aggregates are formed by a seeding/nucleation mechanism that enables them to spread throughout the brain during the course of the disease. In this project we will develop, validate and utilize a highly relevant screening assay based on the powerful PMCA technique invented and developed in our group to identify and develop novel drugs for AD treatment.

PI_NAMEs: SOTO, CLAUDIO  (contact)

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: abeta accumulation;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease therapy;amplification detection;Amyloid;Amyloid beta-Protein;amyloid pathology;Animal Model;Biological;Biological Assay;Blood;Brain;Brain Injuries;Cell model;Cellular Assay;Cerebrospinal Fluid;Chemicals;Clinical Trials;Dementia;Dendrites;Deposition;Detection;Development;Disease;drug candidate;drug development;Drug Industry;drug repurposing;Drug Targeting;Drug usage;Elderly;Event;extracellular;FDA approved;Genetic;Goals;high throughput screening;hyperphosphorylated tau;in silico;In Vitro;inhibitor;Institution;invention;Knowledge;Libraries;Liquid substance;Medical;meter;misfolded protein;Molecular;mouse model;National Center for Advancing Translational Sciences;Natural Compound;Natural Products;Nerve Degeneration;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;neuronal cell body;Neuronal Dysfunction;Neurons;Neuropil Threads;novel;novel therapeutics;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Peptides;Persons;Pharmaceutical Preparations;Phase;Pilot Projects;Population;prevent;Prion Diseases;Procedures;Process;Property;protein aggregation;protein misfolding cyclic amplification;Proteins;PrP;Reagent;Reporting;Reproducibility;Research Personnel;scale up;screening;Screening procedure;Senile Plaques;small molecule;small molecule libraries;Specificity;Structure;tau aggregation;tau Proteins;tau-1;Techniques;Technology;Testing;therapeutic candidate;Transgenic Mice;Tube;United States National Institutes of Health;Urine;Validation

PROJECT_TITLE: Development and validation of a high throughput screening assay for identification of tau aggregation inhibitors in Alzheimer's disease

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE This application will investigate the role of MeCP2 Ser421 phosphorylation (p421) in the antidepressant action of ketamine. We observe a requirement of MeCP2 Ser421 in the sustained, but not acute, antidepressant action of ketamine suggesting distinct mechanisms for prolonged versus rapid drug action. We propose to test a mechanistic model that transitions the acute rapid antidepressant actions of ketamine with MeCP2 pSer421 dependent sustained effects.

PI_NAMEs: MONTEGGIA, LISA M (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: abuse liability;Acute;Adverse effects;Affect;Agreement;Anesthetics;Animal Model;antagonist;anti-depressive agents;antidepressant effect;Behavioral;Brain-Derived Neurotrophic Factor;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcineurin;Calcium;Calcium Signaling;calmodulin-dependent protein kinase II;Chemosensitization;Clinical;design;Disabling;Disease;Disease remission;Dose;drug action;Drug Targeting;Equilibrium;Event;Exhibits;experimental study;Feedback;Frequencies;gain of function;Gene Expression;Genetic Transcription;Hippocampus;Hour;Individual;Intravenous;Ketamine;Knock-in Mouse;Laboratories;Link;Maintenance;Mediating;Mental Depression;Methyl-CpG-Binding Protein 2;Modeling;Molecular Target;mouse model;Mutant Strains Mice;N-Methyl-D-Aspartate Receptors;Neurobiology;Neurons;neurotransmission;novel;Pathway interactions;Patients;Persons;Phosphorylation;Play;postsynaptic;Regulation;Regulator Genes;Research;response;Role;Signal Pathway;Signal Transduction;Synapses;synaptic function;Synaptic plasticity;System;Testing;Time;transcription factor;Transcription Process;Transcriptional Regulation;Translations;treatment-resistant depression;Work

PROJECT_TITLE: Role of Mecp2 in rapidly acting antidepressant action.

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: Project Narrative Inhibition of remyelination and neurorepair is a hallmark of many neurological disorders including multiple sclerosis and neurodegenerative diseases. Overcoming the inhibitory effect of toxic factors in brain lesions on remyelination is essential to promote neurorepair for devastating neurological diseases. The proposed research will address this public health concern by identifying novel compounds that overcome extrinsic inhibition of remyelination with the potential to facilitate repair and slow disease progression in neuroinflammatory diseases like Multiple Sclerosis.

PI_NAMEs: AKASSOGLOU, KATERINA  (contact)

PROJECT_TERMS: Adverse effects;Animal Model;Antiinflammatory Effect;assay development;Astrocytes;axon injury;Biological Assay;Blinded;Blindness;Blood - brain barrier anatomy;Blood coagulation;blood-brain barrier disruption;bone morphogenetic protein receptor type I;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;Brain;Cells;Cholesterol;cholesterol biosynthesis;Chronic;Clinical;clinical development;Demyelinating Diseases;Demyelinations;Deposition;Disease;Disease Progression;Dose;drug discovery;effective therapy;Exclusion;Experimental Autoimmune Encephalomyelitis;FDA approved;Fibrin;Fibrinogen;Future;glial activation;Goals;Grant;Hemorrhage;high throughput screening;Human;Image;improved;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;Interferons;Lesion;Libraries;Link;Medicine;meter;Molecular Target;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;multiple sclerosis treatment;Myelin;Myelin Sheath;myelination;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;neuropathology;novel;oligodendrocyte progenitor;Oligodendroglia;Oxidative Stress;Paralysed;Permeability;Pharmaceutical Preparations;Phase;polymerization;Polymers;prevent;Production;Property;Public Health;receptor;Receptor Activation;receptor expression;Receptor Signaling;Reference Standards;remyelination;repaired;Reproducibility;Research;response;Safety;screening;Signal Transduction;Signaling Protein;small molecule;small molecule inhibitor;stem cell differentiation;stem cell fate;stem cells;success;Testing;Toxic effect;validation studies;Work

PROJECT_TITLE: OPC-X screen: Discovery of small molecule inhibitors to overcome extrinsic inhibition of remyelination.


NIH_SPENDING_CATS: Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STANFORD

ORG_DEPT: NEUROSURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Cerebrospinal fluid (CSF) provides a stable fluid cushion to the brain and carries components that can control brain development, maintenance, and aging. Building on our recent finding that concentrations of CSF electrolytes change as the brain matures, this proposal uses cutting-edge imaging, genetic, molecular, and gene-therapy techniques to test the hypothesis that these shifts in CSF electrolytes are necessary to facilitate brain generation and electrical activity. Outcomes of this innovative research program will have major implications for how we understand the fundamental processes that are critical to brain development, will clarify pathophysiology underlying CSF biomarkers, and will inform future efforts to harness CSF to mitigate developmental mental health disorders.

PI_NAMEs: FAME, RYAN MARIE (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Acceleration;Acute;Address;Adult;Affect;Affective;Aging;Apical;autism spectrum disorder;Axon;Biological Markers;Brain;brain control;BRAIN initiative;cell fate specification;cell motility;Cell Physiology;Cerebrospinal Fluid;Cognitive;Complex;Dendrites;design;Development;Developmental Delay Disorders;Diagnosis;Disease;Drops;Elderly;Electrolytes;Embryo;Environment;Epilepsy;Equilibrium;extracellular;FOS gene;Functional disorder;Future;gamma-Aminobutyric Acid;Gene Delivery;gene therapy;Generations;Genetic;Goals;Growth;Health;Hour;Human;Image;Immediate-Early Genes;in vivo;Induced Neurons;Injury;innovation;Interruption;Intrathecal Injections;Ion Cotransport;Ions;knock-down;Knock-out;Knowledge;Liquid substance;Maintenance;Maps;Measures;Mediating;Mental disorders;migration;Molecular;Mus;National Institute of Mental Health;nerve stem cell;neural;neurodevelopment;neurogenesis;Neurologic Symptoms;Neurons;neurophysiology;neuropsychiatry;novel;Osmosis;Outcome;overexpression;Pathologic;Perinatal;photolysis;Physiological;Physiology;postnatal;Potassium;premature;Prevention;Process;progenitor;programs;Proliferating;Proteins;Research;Research Personnel;response;Rodent;Role;Schizophrenia;Side;Signal Transduction;Social Processes;sodium-potassium-chloride cotransporter 1 protein;Sodium-Potassium-Chloride Symporters;Source;Spinal Cord;stem cell niche;stem cell proliferation;Strategic Planning;Structure of choroid plexus;Supplementation;Techniques;Testing;Therapeutic;Tissues;tool;Visualization;Work

PROJECT_TITLE: How cerebrospinal fluid (CSF) potassium supports brain development and activity


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Estrogen;Neurosciences;Physical Activity;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Sex differences in the maintenance and physiological response to physical activity are predicted to contribute to differences in frailty risk and progression between aging women and men. Using a recently developed gene engineering strategy that activates neurons responsible for driving physical activity in female mice, we will determine if increasing daily activity levels ameliorates frailty phenotype, and if these health and longevity benefits are correlated with changes in liver output.

PI_NAMEs: INGRAHAM, HOLLY A. (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: active lifestyle;Affect;Age;age related decline;aged;Aging;Attenuated;Automobile Driving;Behavior;Biological;biological adaptation to stress;Brain;Bypass;catalyst;Chronic;Chronic Disease;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Development;Disproportionately impacts women;dosage;Drops;Endotoxins;Energy Metabolism;Engineered Gene;ESR1 gene;Estradiol;Estrogens;Exercise;Exhibits;experience;Exposure to;Fatigue;Female;frailty;functional decline;Gait;Gene Activation;Gene Expression;Goals;Hand Strength;Health;Health Benefit;Health Promotion;Hepatic;High Prevalence;Histologic;Hormonal;Human;human model;Hypothalamic structure;Immune;Immunity;Impairment;improved;Inflammatory;inflammatory marker;Intervention;Label;Life Cycle Stages;lifestyle intervention;Lipopolysaccharides;Literature;Liver;Longevity;Maintenance;male;Mass Spectrum Analysis;Mediating;Medical;Melanocortin 4 Receptor;men;Metabolic;Metabolism;Modeling;Molecular;mortality;Motor Activity;mouse model;Mus;Nerve Degeneration;neuroinflammation;Neurons;old mice;Operative Surgical Procedures;Output;Pharmacological Treatment;Phenotype;Physical activity;Physiological;Physiology;Population;Postmenopause;Prevalence;prevent;Process;programs;Rationalization;Regulation;reproductive;Research;response;Risk;Risk Factors;Rodent;sedentary;sedentary lifestyle;sex;Sex Bias;Sex Differences;Signal Transduction;Spectrometry;steroid hormone;Stress;stressor;Syndrome;Testing;translational potential;Woman

PROJECT_TITLE: Targeting Estrogen-Sensitive Hypothalamic Neurons to Reverse Frailty in Aging Females


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The proposed research is relevant to public health because it is aimed at addressing low utilization of mental health services that lead to delayed diagnosis and treatment, and increased morbidity and mortality related to mental illness among Black adults. The proposed research is relevant to the mission of the NIMH to enhance the efficacy and precision of interventions, as it is proposed to design and test the feasibility of an anti-stigma intervention that better defines the optimal intervention conditions and mechanistic targets (stigma and medical mistrust) to promote uptake of mental health services. Thus, the findings are expected to enhance mental health treatment outcomes among millions of Black adults with mental illness in the United States.

PI_NAMEs: BAMGBOSE PEDERSON, ADERONKE  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Anxiety;Black race;Caring;Characteristics;Chronic Disease;clinical trial analysis;community engaged research;Conduct Clinical Trials;Data;design;Diagnosis;digital mental health;disability;Ethnic Origin;feasibility testing;Future;Goals;health disparity;Health Promotion;health service use;improved;Individual;innovation;internalized stigma;Intervention;intervention effect;Literature;Mediating;Mediation;Medical;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentors;Meta-Analysis;mhealth interventions;Mission;mobile application;Morbidity - disease rate;mortality;National Institute of Mental Health;Outcome;personalized intervention;Premature Mortality;primary outcome;Process;Public Health;Race;randomized trial;Religiosity;Research;Research Personnel;secondary outcome;Self Administration;service utilization;skills;social stigma;Symptoms;Testing;therapy design;therapy development;Training;Treatment outcome;trial design;United States;uptake;user centered design

PROJECT_TITLE: Design and Feasibility of a Mobile Mental Health Stigma Reducing Intervention towards Optimization of Care for Black Adults with Depression and Anxiety

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Depression;Mental Health;Mental Illness;Microbiome;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The high prevalence of anxiety and depression in adolescents, paired with a lack of universally effective treatments, constitutes a significant public health concern. The goals of this project are to identify gut-brain signaling pathways that underlie anxiety and depression symptoms in adolescents, examine how they are impacted by environmental risk factors for psychopathology (adversity), and when in development they are most impacted. The long-term goal is to translate the research findings into novel microbiome-targeted therapeutics.

PI_NAMEs: CALLAGHAN, BRIDGET L (contact)

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: Acceleration;Acetates;Adolescence;Adolescent;Age;American;Amides;Animals;Anxiety;Anxiety Disorders;anxiety symptoms;Aromatic Amino Acids;Automobile Driving;Behavior;Blood specimen;Brain;caregiving;Child Abuse and Neglect;Childhood;Clinical;Clostridium;Corpus striatum structure;Data;Decision Making;depressive symptoms;design;Development;Diagnosis;effective therapy;Enrollment;Environmental Impact;Environmental Risk Factor;experience;Fatty Acids;Feces;Gene Cluster;Genes;Goals;gut microbiome;gut-brain axis;High Prevalence;Human;indexing;innovation;interest;Iron;Learning;life span;lifetime risk;Literature;Longitudinal Studies;Magnetic Resonance Imaging;Major Depressive Disorder;Measures;Mediating;Mediation;Mental Depression;metabolomics;Metagenomics;microbial;microbiome;microbiome therapeutics;Microglia;neural;neural circuit;neurodevelopment;neuroimaging;neuromelanin;neuroregulation;neurotransmission;novel;Outcome;Pathway interactions;Peripheral;Plasma;Prevention;Proxy;Psychopathology;Public Health;Research;reward processing;Rewards;Risk;Risk Behaviors;Signal Pathway;Signal Transduction;Substantia nigra structure;System;targeted treatment;Testing;theories;Time;Tissues;Translating;Ventral Tegmental Area;Volatile Fatty Acids

PROJECT_TITLE: Dopaminergic Gut-Brain Signaling on Adolescent Reward Learning After Adversity: Toward New, Noninvasive Treatments for Depression and Anxiety


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

PHR: NARRATIVE Prenatal alcohol exposure (PAE) is common and highly disabling in children and poorly responsive to treatment. ADHD has similar symptoms to PAE and a safe, well-tolerated new therapy for ADHD—trigeminal nerve stimulation (TNS)—has emerged in the last few years. We propose, for the first time, to conduct a formal clinical trial of TNS for children with PAE to measure behavioral changes and to study where in the brain TNS might be exerting its effects using neuroimaging.

PI_NAMEs: O'NEILL, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Address;Affect;Aftercare;Anterior;Attention deficit hyperactivity disorder;Awareness;Behavior;behavior measurement;Behavior Therapy;behavioral response;Behavioral Symptoms;Brain;brain based;brain magnetic resonance imaging;Brain region;Child;Childhood;Classification;Clinical;clinical efficacy;clinical predictors;Clinical Trials;cost;Cross-Over Trials;Data;Diffusion Magnetic Resonance Imaging;Disabling;Disease;Distress;Dose;Double-Blind Method;effective therapy;efficacy evaluation;Electroencephalography;Executive Dysfunction;executive function;Exercise;Failure;Family;feasibility testing;Fetal Alcohol Exposure;follow-up;Forehead;frontal lobe;Functional Magnetic Resonance Imaging;Glutamates;Hyperactivity;Image;Impairment;improved;Impulsivity;inattention;indexing;Individual;individual patient;Inferior;Investigation;Laws;Long term disability;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;minimal risk;Modality;Myelin;Neurodevelopmental Disorder;neuroimaging;novel;novel therapeutics;Parents;Patients;Pharmaceutical Preparations;Phase;Positron-Emission Tomography;predicting response;Procedures;Prognostic Marker;Property;prospective;psychostimulant;Randomized;Randomized Controlled Clinical Trials;reduce symptoms;response;Rest;Sampling;Schools;side effect;Site;Sleep;social;Stimulant;Stress;substance misuse;symptom treatment;Symptoms;System;Testing;Therapeutic Effect;Time;Tissues;Training;Trigeminal nerve structure;Validation;white matter;Work

PROJECT_TITLE: Trigeminal Nerve Stimulation for Prenatal Alcohol Exposure

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Nutrition;Obesity;Physical Activity;Prevention;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Narrative How to achieve lasting improvements in diet and physical activity to maintain health in mid-life and improve later-life health is a pressing public health challenge. By more accurately estimating the role of environmental factors in dietary and physical activity behaviors, the proposed study will inform new lifestyle interventions, as well as promising targets for environmental and policy change. This can reduce obesity and the chronic disease burden for adults during midlife and later-life.

PI_NAMEs: BRONAS, ULF G;KERSHAW, KIARRI N;TINTLE, NATHAN L (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Accelerometer;adaptive intervention;Address;Adult;Affect;African American;Age;aged;Attention;Attenuated;Behavior;behavior influence;Behavioral;behavioral study;Body Weight;burden of chronic illness;Cellular Phone;Characteristics;Child;Chronic Disease;Cities;Crime;Cues;Day Care;Diet;Diet Surveys;dietary;disability;Disparity;Ecological momentary assessment;Education;Environment;environmental change;Environmental Exposure;Environmental Risk Factor;ethnic diversity;executive function;experience;Failure;fast food;fitness;Food;Gender;Geography;Global Positioning System;Goals;Health;Home;Hour;human old age (65+);improved;Inequity;Informal Social Control;innovation;Intervention;late life;Latinx;Leisures;Life;Life Style;lifestyle intervention;Location;Malignant Neoplasms;Masks;Measurement;Measures;Methodology;middle age;Moderate Activity;Moods;Movement;Neighborhoods;novel strategies;Obesity;obesity risk;Outcome;Persons;Physical activity;Play;Policies;Population;Prevention Research;Public Health;Questionnaires;racial diversity;Recreation;Research;Resources;response;Restaurants;Role;Safety;Sampling;Shapes;suburb;Testing;theories;Time;trait;Variant;walkability;Work;Youth

PROJECT_TITLE: A Dynamic Environmental Exposure Approach to Study Behaviors in Mid-Life

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-V(02)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Asthma;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Lung;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative: Human-generated and natural-source particulate air pollutants (i.e., PM2.5-10) in the air we breathe are a health risk. Our research is focused on discovering how different forms of environmental PM adversely affect the lungs and human health. Ultimately, we hope to use our findings to create solutions for improving human health.

PI_NAMEs: REILLY, CHRISTOPHER A (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acute;Adverse effects;Affect;Agonist;Air;Air Pollutants;Air Pollution;airway epithelium;Amino Acids;ANK1 gene;antagonist;Asthma;asthma exacerbation;Binding;Biochemical;biomass smoke;Breathing;bronchial epithelium;Caring;Cells;Child;Chimeric Proteins;chronic respiratory disease;chronic rhinosinusitis;cigarette smoke;Clinics and Hospitals;Coal;Coupled;Coupling;cytokine;cytotoxic;Data;Development;Diagnosis;Diesel Exhaust;differential expression;Ectopic Expression;effective intervention;Electronics;Enrollment;Environment;environmental particulate;Epithelial Cells;Etiology;Event;Exposure to;fine particles;fly ash;Genetic;Genotype;Goals;Health;Hospitalization;Human;Human Genetics;humanized mouse;Hypersensitivity;improved;Individual;Inflammatory;Inflammatory Response;innovation;insight;Intervention;Ion Channel;Knowledge;Leucine-Rich Repeat;Link;Liquid substance;Lung;Lung Diseases;Malaise;marenostrin;Mediator;Medical;Modeling;Modification;Molecular;mutant;Nasal Epithelium;Natural Source;NF-kappa B;novel;novel strategies;Nucleotides;Outcome;Particulate;Particulate Matter;Pathologic;Pathway interactions;Patient Self-Report;Pediatric Hospitals;Persons;Phenotype;predictive marker;Premature Mortality;prevent;Process;Prognostic Marker;programs;Property;recruit;Research;respiratory;Respiratory Disease;response;Risk;Rodent;Rodent Model;Sampling;Scheme;sensor;Severities;Single Nucleotide Polymorphism;Site;SNP genotyping;Symptoms;Toxic effect;Toxicology;Translating;Translations;TRP channel;TRPA channel;TRPV1 gene;Universities;Utah;Vanilloid;Work

PROJECT_TITLE: TRP Channels and Air Pollution

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: SOUTH TEXAS VETERANS HEALTH CARE SYSTEM

PHR: Lymphoma, a tumor of the blood cells, is the fifth most common cancer type in the western world. Importantly, lymphoma is one of the few cancers for which the risk was significantly increased among Vietnam veterans. In addition, more recent data (1996-2007) from Italian army peacekeeping troops in the Balkans, also preliminarily suggested an increase in lymphoma incidence. Although the mechanism associated with this elevated risk of lymphoma development have not been fully defined, chemical exposure in the battlefield as well as contact with infectious agents are likely possibilities. Thus, it should be expected that with the current extended deployment of US military forces in foreign lands, a new wave of increased lymphoma diagnosis in military personnel may ensue. To specially attend to the needs of this population, we critically need research that: a) leads to a better understanding of lymphoma biology, b) identifies novel biomarkers for diagnosis and early detection, and c) facilitates the development of more effective and less toxic therapeutics.

PI_NAMEs: AGUIAR, RICARDO C (contact)

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;alpha ketoglutarate;Area;B-Cell Lymphomas;Balkans;base;Binding;Biology;Blood Cells;cancer type;Cell Line;Chemical Exposure;chromatin immunoprecipitation;Data;defined contribution;demethylation;Development;Diagnosis;Distal;DNA;DNA Methylation;Early Diagnosis;Enhancers;Enzymes;Epigenetic Process;Exercise;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;Genetic Transcription;Genomics;Glioma;Growth;Hexosamines;Histones;Human;Hyperactivity;In Vitro;in vitro Model;in vivo;Incidence;Infectious Agent;large cell Diffuse non-Hodgkin's lymphoma;Leukemic Cell;Link;Location;Lymphoma;Lymphomagenesis;Malignant Neoplasms;Maps;Mediating;Metabolic;Metabolism;Methylation;Military Personnel;Mitochondria;mitochondrial metabolism;Mixed Function Oxygenases;Modeling;mouse model;Mus;Myeloid Cells;Nature;novel;novel marker;Nuclear;O-GlcNAc transferase;Oncogenic;Organelles;Outcome;Output;oxidation;Oxidoreductase;Pathology;Pathway interactions;Physiology;Play;Population;Post-Translational Protein Processing;Process;programs;Proliferating;promoter;Reporter;Reporting;Research;Resolution;Risk;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;segregation;Signal Transduction;stem cell biology;Stem Cell Development;Testing;Tetanus Helper Peptide;Therapeutic;transcription factor;tumor;Tumor Suppressor Proteins;Veterans;Vietnam;Western World;Work

PROJECT_TITLE: Post-Translational Control of TET Function in Lymphoma


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARATIVE There is a national shortage of qualified clinician-scientists able to conduct the rigorous clinical research needed to optimize cancer prevention and treatment. The Cancer Clinical Epidemiology Training Program (CCETP) will produce a cadre of skilled investigators who are well positioned to develop independent academic careers and to become national leaders in cancer-focused clinical research. The program’s success is ensured by a distinguished, experienced, and committed training program faculty working in an exceptionally rich and diverse clinical research training environment.

PI_NAMEs: APLENC, RICHARD ;GLANZ, KAREN  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Cancer Clinical Epidemiology Training Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Gram-negative bacteria producing metallo-β-lactamases, MBLs, are a significant threat to our public health. MBLs confer resistance to “last resort” β-lactams (e.g., imipenem) and resist all available β-lactamase inhibitors (BLIs). We have designed a series of innovative compounds, bisthiazolidines (BTZs) and thiazolidines (TZs) that are potent MBL BLIs that are non-toxic. The overarching objectives of this project are to embark upon a “high risk-high reward” drug development program to design an effective oral MBL inhibitor that can be partnered with the oral carbapenem, tebipenem pivoxil (Tbp-Pvx). We have identified a lead compound, (L syn CS319) that effectively lowers MICs to within the susceptible range when paired with meropenem. We will partner with the Walter Reed Army Institute of Research (WRAIR), in addition to industry consultants. These are clear priorities for the VHA and the US Military.

PI_NAMEs: BONOMO, ROBERT A. (contact)

PROJECT_TERMS: absorption;Achievement;acyl group;alternative treatment;Animal Model;Antibiotics;Argentina;Bacteria;bactericide;beta-Lactamase;beta-Lactams;Binding;Binding Proteins;Biological;Biological Availability;carbapenem resistance;carbapenemase;Carbapenems;Carboxylic Acids;Cephalosporinase;Cephalosporins;Chemicals;Clinical;clinical application;Collaborations;comparison control;Coupled;cytotoxicity;design;Development;drug development;drug discovery;Evaluation;Exhibits;Extended-spectrum β-lactamase;Formulation;Foundations;Gastrointestinal tract structure;Goals;Gram-Negative Bacteria;healing;high reward;high risk;Hydrolysis;Imipenem;improved;in vitro testing;Industry;Infection;inhibitor;innovation;Intestinal Absorption;Investigation;Investigational New Drug Application;Investigational Therapies;joint infection;Knowledge;L Forms;Lactams;Lead;Mediating;Medical;Meropenem;Metabolic;Metals;meter;Methods;Military Personnel;Modeling;mouse model;Mus;Nature;novel;novel therapeutics;Oral;Osteomyelitis;pathogen;Patients;Penicillins;pharmacokinetics and pharmacodynamics;Predisposition;Prodrugs;Program Development;programs;Property;Public Health;Reaction;Research Institute;Resistance;Scientist;Series;Serine;Serum;Skin Tissue;soft tissue;stem;Sulfhydryl Compounds;Testing;Therapeutic;Thigh structure;thioester;Uruguay;Veterans Health Administration;wound;Wound Infection

PROJECT_TITLE: Oral Metallo-Beta-Lactamase Inhibitors: Exploiting Reaction Mechanisms


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Complications from chronic infectious diseases contribute to significant morbidity and mortality in the Veteran population. Effector and memory T lymphocytes are cells of the immune system that provide protection against infections. Our goal is to understand how these cells are generated and how they function in response to different infections. These studies may help our efforts to improve vaccines.

PI_NAMEs: CHANG, JOHN T (contact)

PROJECT_TERMS: Acute;adaptive immunity;Adoptive Transfer;antigen-specific T cells;Bacterial Infections;Body Surface;CD8-Positive T-Lymphocytes;cell type;Cells;Chronic;Colon;Communicable Diseases;Cytometry;Data;Effector Cell;Face;first responder;Gene Expression;Gene Expression Profiling;Gene Targeting;Genes;Genetic Transcription;genome-wide;Goals;Health;Heterogeneity;HIV/HCV;Host Defense;Immune response;Immune system;Immunity;Immunologic Memory;improved;in vivo;Infection;innovation;insight;intestinal epithelium;Kidney;knock-down;Liver;Measurement;Memory;Methods;microbial;military veteran;Molecular;Morbidity - disease rate;mortality;neutralizing antibody;novel;Pathway interactions;Phase;Population;Proteins;rational design;Reporting;response;RNA Interference;Sentinel;single-cell RNA sequencing;small hairpin RNA;Small Intestines;Specific qualifier value;T cell regulation;T memory cell;tissue resident memory T cell;Tissues;Transcriptional Regulation;transcriptome;Transgenic Organisms;vaccination strategy;Vaccine Design;vaccine development;Vaccines;Validation;Veterans;Work

PROJECT_TITLE: Transcriptional regulation of T cell immunity


ORG_CITY: PHOENIX

ORG_NAME: PHOENIX VA HEALTH CARE SYSTEM

ORG_STATE: AZ

PHR: NARRATIVE Exposure to ultraviolet light during military training and active duty is a major risk factor for melanoma in military personnel and Veterans. Given that active duty military members have an increased incidence of melanoma, that Veterans of previous campaigns have also had high ultraviolet exposures, and that melanoma takes years to develop and metastasis, melanoma is a significant health problem facing Veterans. This project will determine the role of the MHC class II antigen presentation pathway in melanoma cells in controlling how the body’s immune system recognizes and destroys melanoma tumors in the absence of therapy and during treatment with immunotherapy. Understanding how this pathway in tumor cells regulates the immune system is anticipated to predict which patients will benefit most from particular immunotherapy drugs and lead to the development of new approaches for cancer treatment to make immunotherapy effective in more patients.

PI_NAMEs: HASTINGS, KAREN TARASZKA (contact)

PROJECT_TERMS: active duty;anti-PD-1;anti-PD1 therapy;anti-tumor immune response;Antigen Presentation;Antigen Presentation Pathway;antigen processing;Antigen-Presenting Cells;Antigens;Area;Biological;cancer infiltrating T cells;Cancer Patient;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;cell type;clinically relevant;Combined Modality Therapy;Data;Development;Enzymes;Exhibits;Exposure to;Genomics;Goals;Health;Histocompatibility Antigens Class I;Histocompatibility Antigens Class II;Immune;immune checkpoint blockade;Immune mediated destruction;Immune system;immunogenic;Immunologics;immunoregulation;Immunotherapy;improved;in vivo;Incidence;interest;Knowledge;Laboratories;Major Histocompatibility Complex;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;member;Military Personnel;military service;military veteran;mouse model;Mutation;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Occupational Exposure;Pathway interactions;Patient-Focused Outcomes;Patients;personalized medicine;Pharmaceutical Preparations;Play;precision medicine;protein complex;Research;Research Priority;Resistance;response;Risk Factors;Role;service member;side effect;Specimen;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Testing;therapy resistant;Training;Treatment Efficacy;treatment response;tumor;Tumor Antigens;tumor growth;Ultraviolet Rays;UV Radiation Exposure;Veterans

PROJECT_TITLE: MHC class II antigen presentation in melanoma: impact on immune recognition


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Clinical Research;Lung

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Neutrophils are immune cells that cause lung damage in several common respiratory diseases including pneumonia and asthma; however, there are currently no therapies that target these cells. We have found that a protein called chitinase 3-Like-1 (Chi3L1) promotes harmful neutrophil responses and worsens lung disease in mouse models of pneumonia. Here, we propose to use cellular, mouse, and human studies to better understand the effects of Chi3L1 on neutrophils, with the ultimate goal of developing new drugs that target Chi3L1 and prevent neutrophil-mediated injury in patients with lung diseases.

PI_NAMEs: GAUTAM, SAMIR  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Achievement;Acute;Acute Respiratory Distress Syndrome;Apoptosis;Apoptotic;Area;Asthma;asthmatic;Award;Biology;career;career development;Cell Death;cell type;Cells;Cellular Assay;Chemicals;CHI3L1 gene;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;collaborative environment;Critical Care;Cystic Fibrosis;cytokine;Development;Disease;disease model;Educational Curriculum;Environment;extracellular;Goals;Human;human disease;Immune;Immunology;Impairment;in vitro Assay;in vitro testing;in vivo;Inflammation;Inflammatory;inflammatory lung disease;Inhibition of Apoptosis;inhibitor;Injury;insight;Internal Medicine;International;Investigation;kinase inhibitor;Laboratory Study;Lectin;Link;Lung;Lung Diseases;lung injury;Lytic;Macrophage;MAP Kinase Gene;Maps;Mediating;Medical;medical schools;Medicine;meetings;Mentors;Mentorship;Modeling;mouse model;Mus;neutrophil;new therapeutic target;novel;novel therapeutic intervention;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Phenotype;phosphoproteomics;physician-scientist training program;Physicians;PIK3CG gene;Play;Pneumonia;pneumonia model;prevent;Property;Proteins;Pulmonary Inflammation;receptor;Recombinants;recruit;Research;Research Personnel;Resolution;Respiratory Disease;response;Role;Science;Scientist;Severities;Severity of illness;Signal Pathway;Signal Transduction;Sleep;Sputum;success;symposium;System;targeted treatment;Technology;Testing;theories;Time;tissue injury;Training;Training Programs;Work

PROJECT_TITLE: Chitinase 3-like-1 regulates neutrophil cell fate in inflammatory lung disease

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: DC

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Hearing Loss;Neurosciences;Pediatric

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE Variants of over 100 human genes have been associated with deafness so far, many of which are associated with the highly specialized architecture of sensory ‘hair’ cells: our conduit between mechanical stimuli, e.g. sound waves, and hearing. The overarching goal of my proposed work is to characterize protein activities and interactions that are vital to hair cell development, function, and lifelong structural maintenance. Basic science research that investigates the biology of this unique and precious cell type will help inform therapeutic strategies relevant to both congenital deafness and environment- or age- related hearing loss.

PI_NAMEs: HARTIG, ELLEN I (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Ablation;Actins;Adult;Affect;age related;antibody detection;Architecture;Auditory;Basic Science;Behavior;Binding;Biology;Birds;Calcium;Calcium ion;Calcium-Binding Proteins;cell type;cellular transduction;Cochlea;Complete Hearing Loss;Complex;congenital deafness;CRISPR/Cas technology;Data;deaf;deafness;Defect;Development;Dimensions;Dysmorphology;EF-Hand Domain;Elements;Elongation Factor;Ensure;Environment;experimental study;Genes;Genetic;Goals;Growth;Hair;Hair Cells;Hearing;hearing impairment;Hearing Tests;Height;Heredity;high resolution imaging;Hour;Human;Image;in vivo;Knockout Mice;Knowledge;Labyrinth;Letters;Life;Light;Link;Maintenance;mechanical stimulus;mechanotransduction;Mediating;Mediator;member;Membrane;Molecular Conformation;Morphogenesis;Morphology;Motor;mouse model;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Myosin ATPase;Natural regeneration;novel;Organ;Organelles;Pattern;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;postnatal;Presbycusis;preservation;prevent;Preventive;protein complex;Protein Isoforms;Proteins;Reporting;Research;RNA Splicing;Role;Sensory;Sensory Hair;sound;Structure;Surface;Techniques;Testing;Therapeutic;Time;Transgenic Mice;Trimethoprim-Sulfamethoxazole;Variant;Work

PROJECT_TITLE: A small calcium-binding protein may be key to stabilizing the sensory hair cell stereocilia Elongation Complex


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: DAVIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative Positron emission tomography (PET) is a molecular imaging technique widely used in clinical diagnostics, and in clinical and preclinical research. However, the performance of current PET systems is far from reaching the theoretical limit in terms of spatial resolution and sensitivity, which limit its application in ultra-low dose imaging and fast dynamic imaging, such as imaging of low-levels of receptors, tracking of therapeutic cells and imaging of cardiac contraction. We propose to develop a small-animal PET scanner with a sensitivity higher than 40%, a spatial resolution better than 1.5 mm3 across the mouse/rat body, and using detector materials with no intrinsic background, to enable ultra-low dose preclinical imaging and fast dynamic imaging in mice/rats. The improved performance will promote the use of total-body small-animal PET imaging for monitoring biological processes that result in very low source activities and expand the range of applications for this powerful, non-invasive and translational imaging modality in preclinical applications.

PI_NAMEs: DU, JUNWEI  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: analog;Animals;Area;Background Radiation;Biochemical;Biological Assay;Biological Models;Biological Monitoring;Biological Process;Bismuth;Cardiac;cardiovascular imaging;Cardiovascular system;Cells;Circulation;clinical diagnostics;Clinical Research;Code;cost;Coupled;data acquisition;Dedications;design;detector;Development;Diameter;disease model;Dose;Electronics;Event;Funding;Geometry;glucose metabolism;Goals;Heart;heart imaging;Hybrids;Image;image translation;imaging modality;Imaging Techniques;improved;in vivo;Individual;Length;Low Dose Radiation;Lutetium;Magnetic Resonance Imaging;Measurement;meter;Methods;Modeling;molecular imaging;Mus;nanomolar;Noise;novel;Outcome;Performance;Polishes;Positioning Attribute;Positron-Emission Tomography;pre-clinical;pre-clinical research;preclinical imaging;preclinical study;Property;Radioisotopes;radiotracer;Rattus;receptor;Receptor Gene;Resolution;Signal Transduction;Source;System;Therapeutic;therapeutic gene;Thick;tool;transgene expression;Work

PROJECT_TITLE: Maximizing sensitivity for ultra-low dose PET imaging

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ORG_CITY: LOUISVILLE

ORG_NAME: LOUISVILLE VA MEDICAL MEDICAL CENTER

ORG_STATE: KY

PHR: Rheumatoid arthritis (RA) is a common cause of disability in Veterans. Although TNF blockers have been used for treatment, unresponsiveness to treatment is high in Veteran RA patients; the mechanism(s) underlying the unresponsiveness is/are unknown. RA commonly involves multiple cell types. It is well-known that exosomes mediate intercellular crosstalk among immune cells, synovial cells, endothelial cells, and chondrocytes, thereby influencing various processes in RA pathogenesis. However, the precise function of exosomes in patients with RA is not fully understood. The results generated from this study will also provide a guideline for administering personalized medicine which would selectively prevent RA pathogenic factor(s) from sorting into RA synovial fibroblast (RASF) exosomes which in turn contribute to RA pathogenesis. In addition, we can identify RASF dependent exosome signatures that may serve as promising biomarkers for diagnosing or assessing RA activity and thus improving the health status of members of the VA patient population.

PI_NAMEs: ZHANG, HUANG-GE  (contact)

PROJECT_TERMS: Affect;Animal Model;ARA9 protein;Arthritis;arthritis therapy;arthropathies;Aryl Hydrocarbon Receptor;Attenuated;Autoimmune Diseases;Biological;Biological Markers;Biological Response Modifiers;Biotin;Biotinylation;bone;Bone Development;bone erosion;Cartilage;cartilage degradation;cell type;Cells;Chondrocytes;Chronic;Complex;CRISPR/Cas technology;Cytosol;Data;Development;Diagnosis;disability;Dissociation;Endothelial Cells;Exocytosis;exosome;experimental study;extracellular;Extracellular Space;Fibroblasts;Future;Guidelines;Health Status;Heat-Shock Proteins 90;High Prevalence;Human;Hyperplasia;Immune;Immunocompetent;Implant;improved;in vivo;Individual;Inflammation;intercellular communication;Invaded;joint destruction;joint inflammation;joint injury;Knock-out;Knowledge;Label;Ligase;MAPK8 gene;Mediating;Mediator;member;men;Military Personnel;Modeling;Molecular Target;mouse model;Mus;Mutate;NF-kappa B;novel therapeutics;Osteitis;Outcome;Outcome Study;Pathogenesis;Pathogenicity;Pathway interactions;patient population;Patients;personalized medicine;Pharmacotherapy;Phosphorylation;Phosphotransferases;Play;Population;precision drugs;predictive marker;Predictive Value;prevent;Prevention;Process;Proliferating;protein protein interaction;Proteins;Publishing;Receptor Activation;receptor expression;recruit;Research;Rheumatoid Arthritis;Role;SCID Mice;Severities;Site;Sorting;Synovial Cell;Synovial Fluid;Synovial Membrane;System;Testing;Therapeutic;Tissues;TNF gene;TNF receptor-associated factor 2;TNF Receptor-Associated Factors;United States Department of Veterans Affairs;valosin-containing protein;Vesicle;Veterans;Virulence Factors;Woman

PROJECT_TITLE: RA synovial fibroblast exosomes(RA-EXo) mediated bone erosion via AhR/TRAF2pathway


ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Schizophrenia is a severe and life-long psychiatric disorder with a higher prevalence in Veterans relative to the general population. Veterans with schizophrenia have elevated rates of unemployment and disability which may be, in part, attributable to cognitive deficits. Cognitive deficits are difficult to treat and have been linked to dendritic spine deficits in the prefrontal cortex. The proposed studies investigate the pathophysiology of cognitive dysfunction in schizophrenia by testing the hypothesis that spine deficits are due to increased phagocytosis of spines by microglia. We test this hypothesis by determining if microglia show molecular features that enable elevated spine phagocytosis and if molecular and morphological indicators of elevated spine phagocytosis in individual microglia are inversely related to neighboring spine density in schizophrenia. These studies will help identify novel targets for microglial inhibitors that may disrupt microglial-mediated spine phagocytosis, repair synaptic connectivity, and improve cognitive function in Veterans with schizophrenia.

PI_NAMEs: VOLK, DAVID W (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Antipsychotic Agents;Area;Binding;brain cell;Cd68;Cell Count;Cell surface;Chronic;Cognitive deficits;cognitive function;cognitive process;Complement;Complement Receptor;CX3CR1 gene;Dendritic Spines;density;disability;Disease;Elements;Functional disorder;General Population;Genes;Genetic;genome wide association study;glial activation;High Prevalence;hippocampal pyramidal neuron;Immune;Immunofluorescence Microscopy;Impaired cognition;Impairment;improved;Individual;inhibitor;Label;Lasers;Ligand Binding;Link;Macrophage-1 Antigen;Mediating;Mediator;Membrane;Mental disorders;Messenger RNA;Microdissection;Microglia;Molecular;Molecular Target;Monkeys;Morphology;mortality;Myeloid Cells;Nature;novel;Phagocytes;Phagocytosis;Phagocytosis Inhibition;Play;Positron-Emission Tomography;Prefrontal Cortex;Process;Purinoceptor;receptor;remediation;repaired;Reporting;Risk Factors;Role;Sampling;Schizophrenia;selective expression;Study Subject;Synapses;Territoriality;Testing;Transcript;TYROBP gene;Unemployment;Variant;Vertebral column;Veterans

PROJECT_TITLE: Microglial Phagocytosis of Dendritic Spines in Veterans with Schizophrenia


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Osteoarthritis

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Osteoarthritis of the hand and wrist are common, disabling conditions; however, relatively limited attention has focused on characterizing the bone motion of the thumb base’s scaphotrapeziotrapezoid joint, which bridges the thumb and wrist joints. Our project investigates structure-function interactions at the scaphotrapeziotrapezoid joint by combining (1) dynamic CT imaging-derived joint-level motion during thumb and wrist activities with (2) variations in bone shape as quantified with statistical shape modeling. These findings will advance our understanding of the healthy scaphotrapeziotrapezoid joint as well as mechanical factors associated with wrist osteoarthritis.

PI_NAMEs: TRENTADUE, TAYLOR PATRICIA (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Age;Age Years;Anatomy;Articulation;Artificial Intelligence;Attention;base;Bilateral;Biological Markers;Biomechanics;biomedical imaging;bone;carpus bone;clinical translation;combinatorial;Communication;Complex;Coupling;Data;Degenerative polyarthritis;Diagnosis;diagnosis standard;Diagnostic;Diagnostic Imaging;diagnostic strategy;Disabling;Disabling condition;Distal;Elderly;evidence base;Facet joint structure;Female;Foundations;Four-dimensional;four-dimensional computed tomography;Geometry;Hand;hand dysfunction;Hand Osteoarthritis;High Prevalence;Image;Imaging technology;Impairment;improved;Incidence;innovation;Intervention;joint stress;Joints;lifetime risk;Lifting;Machine Learning;Measurement;Measures;Mechanics;Methods;Modeling;Morphology;Motion;novel;Operative Surgical Procedures;Pain;Participant;Pathogenesis;Pathologic;Patients;Pattern;photon-counting detector;Positioning Attribute;pre-clinical;pressure;Prevalence;Protocols documentation;Proxy;Quality of life;Radial;radiological imaging;Resistance;Resolution;Role;Scaphoid bone;Series;sex;Shapes;Side;Site;Stress;Structure;Structure-Activity Relationship;Surface;synergism;Techniques;Technology;temporal measurement;Therapeutic;Thumb structure;Time;tool;Translations;transmission process;trapezium;Trapezoid bone structure;treatment strategy;two-dimensional;Variant;Visualization;Work;Wrist;Wrist joint;wrist motion;X-Ray Computed Tomography

PROJECT_TITLE: Assessing scaphotrapeziotrapezoid arthrokinematics using 4DCT


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: Project Narrative At least 30% of Iraq and Afghanistan veterans are affected by Major Depressive Disorder (MDD). Conventional pharmacological treatment produces temporary remission in <50% of patients. Thus, there is an urgent need for novel therapeutic approaches to target MDD and psychological stress-related mood disorders. MDD is associated with damage to the blood brain barrier (BBB) and damage to the epithelium, potentially allowing for infiltration of cytokines into the brain and maladaptive inflammatory responses to stress. In this study, we will identify regional gene expression and epithelial structural changes in response to psychological stress to offer potential innovative therapeutic approaches to prevent stress-related depression and mood disorders.

PI_NAMEs: PASINETTI, GIULIO MARIA (contact)

PROJECT_TERMS: Affect;Affinity Chromatography;Afghanistan;Anhedonia;Animals;anti-depressive agents;Anxiety;anxiety-like behavior;Area;Arterial Fatty Streak;Astrocytes;Automobile Driving;Award;Bacterial Artificial Chromosomes;Behavior;Behavioral;behavioral phenotyping;Bioinformatics;Blood;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier penetration;blood-brain barrier permeabilization;Brain;brain parenchyma;Brain region;brain tissue;Cardiovascular Diseases;cardiovascular risk factor;Cells;Chronic;Chronic stress;Clinical Research;Coupled;cytokine;Cytometry;Data;depression model;Development;Disease remission;Endothelial Cells;Endothelium;Epithelium;Exposure to;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Goals;Health;Human;Immune;immune cell infiltrate;Immune signaling;Immune System Diseases;Immunologics;Impairment;Individual Differences;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Innate Immune System;innovation;interest;Interleukin-6;Iraq;Knowledge;Link;Major Depressive Disorder;Measures;Mediating;Mental Depression;Messenger RNA;Modeling;Monitor;monocyte;Mood Disorders;Moods;Morbidity - disease rate;mortality;Mus;neural circuit;neurovascular;neurovascular injury;new technology;novel;novel therapeutic intervention;Nucleus Accumbens;Pathogenesis;Pathology;Patients;Pattern;Peripheral;Pharmacological Treatment;Phenotype;Physical Function;Play;Post-Traumatic Stress Disorders;pre-clinical;preclinical study;Predisposition;Prevalence;prevent;Proteins;psychologic;Psychological Models;Psychological Stress;Publications;recruit;Recruitment Activity;Reporting;resilience;response;Ribosomes;Role;Rupture;Series;severe mental illness;Signal Transduction;social;social defeat;social stress;Stress;Structure;Surface Antigens;symptomatology;Symptoms;Testing;Therapeutic;Tight Junctions;transcriptome sequencing;transcriptomics;Translating;Validation;validation studies;Veterans;Withdrawal;Work

PROJECT_TITLE: Validation of Immune Dysfunction in Model of Social Stress: Implications for Major Depression Disorder in Veterans


FUNDING_MECHANISM: OTHERS

ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PI_NAMEs: PARLET, COREY  (contact)

PROJECT_TERMS: Active Immunization;adaptive immune response;Adaptive Immune System;Antibiotics;Antibodies;Antibody Response;Antigens;antimicrobial;Ants;B-Lymphocytes;Biological;bone;CD4 Positive T Lymphocytes;Cell Count;cell growth;Cells;Cellular Immunity;Characteristics;Clinical;Communities;Consensus;cost;Cutaneous;Data;defense response;design;Development;Disease;Disease Outbreaks;disorder control;draining lymph node;Drug or chemical Tissue Distribution;Drug resistance;Elements;Engineering;Equipment;Event;Exotoxins;Exposure to;Generations;Genus staphylococcus;healing;Heart Valves;Host Defense;Humoral Immunities;Hygiene;IL17 gene;Immune;Immune response;Immunity;Immunize;Immunocompetent;Immunologic Memory;Immunologics;Individual;Infection;Infectious Agent;Infectious Skin Diseases;Injury;Kinetics;Knock-out;knockout gene;langerin;Life;Maintenance;Measures;Mediating;Mediator;Memory;methicillin resistant Staphylococcus aureus;Military Personnel;Mission;Modeling;Molecular;Mus;neutrophil;Organism;OVA 323-339;Ovum;pandemic disease;pathogen;Peptides;Population;Prevalence;prevent;Preventive vaccine;Primary Infection;Process;programs;prophylactic;Public Health;recruit;Research;resistant strain;response;Risk;Role;Scourge;Sepsis;Site;Skin;Skin injury;Soft Tissue Infections;Staphylococcus aureus;Staphylococcus aureus infection;Sterility;Structure;Structure of germinal center of lymph node;System;T-Lymphocyte;Testing;Time;Tissues;Toxin;Training;Trauma;uptake;vaccination strategy;Vaccine Design;Vaccines;Virulence;Virulence Factors

PROJECT_TITLE: Mechanisms of Staphylococcus aureus-induced changes in cutaneous T cell networks


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

PHR: The proposed project aims to develop a more effective, neuroscience-informed smoking cessation treatment for Veterans with posttraumatic stress disorder (PTSD). Veterans with PTSD are at increased risk of smoking-related health consequences due to difficulty quitting and to current smoking cessation interventions. Thus, more effective treatment options are needed. The US Food and Drug Administration recently cleared a form of non-invasive brain stimulation, repetitive transcranial magnetic stimulation (rTMS), as a smoking cessation treatment for adults. However, it is unclear whether rTMS would be effective for Veterans, especially those with PTSD. The proposed research aims to advance VA healthcare by studying rTMS in Veterans with PTSD who desire to quit smoking and to personalizing rTMS therapy with the use of functional magnetic resonance imaging (fMRI). This line of research may not only develop a more effective treatment for smoking cessation for Veterans with PTSD but may also lead to improved treatment options for Veterans with other substance use disorders and co-occurring mental illness.

PI_NAMEs: YOUNG, JONATHAN R (contact)

PROJECT_TERMS: Abstinence;acceptability and feasibility;active comparator;Adult;Affect;alternative treatment;Award;Brain;Carbon Monoxide;career;Cause of Death;Cessation of life;Chronic;Cigarette;Clinical;clinical efficacy;Clinical Research;Clinical Trials;Cognitive Therapy;comorbidity;Confidence Intervals;Consumption;Data;Development;Devices;disability;Double-Blind Method;Economics;effective therapy;Eligibility Determination;Enrollment;Ensure;evidence base;Exclusion;Exhalation;experience;Feasibility Studies;feasibility trial;Functional Magnetic Resonance Imaging;General Population;Goals;Grant;Health;Healthcare;improved;independent component analysis;Individual;innovation;insight;Insula of Reil;Intervention;Knowledge;Life Expectancy;Major Depressive Disorder;Measures;Mental disorders;Mental Health;Mentors;Methodology;Methods;Modality;multi-component intervention;multimodality;neural;neural circuit;neural network;neuroimaging;Neuronavigation;neuroregulation;Neurosciences;nicotine replacement;noninvasive brain stimulation;novel;open label;Outcome;Participant;Pharmacotherapy;Physicians;placebo group;poor health outcome;Population;Post-Traumatic Stress Disorders;Prefrontal Cortex;Preparation;Procedures;Psychotherapy;Public Health;Randomized;Randomized, Controlled Trials;recruit;repetitive transcranial magnetic stimulation;Research;research study;Research Training;Resistance;Rest;retention rate;Risk;Sampling;Scientist;skills;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking initiation;smoking prevalence;Structure;Structure of postcentral gyrus;Study Section;substance use;Substance Use Disorder;substance use treatment;System;Techniques;Testing;Therapeutic;Tobacco smoking behavior;Tobacco use;Tobacco Use Disorder;Traction;Training;Training Support;Transcranial magnetic stimulation;Trauma;trauma exposure;treatment effect;trial comparing;trial design;Uncertainty;United States;United States Department of Veterans Affairs;United States Food and Drug Administration;Veterans;Vulnerable Populations;Work;Writing

PROJECT_TITLE: Neuroimaging correlates and feasibility of transcranial magnetic stimulation (TMS) to improve smoking cessation outcomes in Veterans with comorbid PTSD


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The University of Wisconsin Carbone Cancer Center (UWCCC), which is a matrix center within the University of Wisconsin School of Medicine and Public Health (SMPH), seeks to dramatically reduce the burden of cancer within and beyond our catchment. Specifically, the UWCCC will do this by decreasing cancer incidence and mortality among populations within our catchment area and beyond, including our minority and underserved populations. We will facilitate pursuit of this goal through partnerships with other health delivery systems and state and community agencies for dissemination of evidence-based findings. The UWCCC will accomplish our goals through nurturing a diverse and supportive cancer community, reliable infrastructure, and efficient resources. During the current funding period, UWCCC continued to decrease the burden of cancer in our catchment and beyond through prioritized research areas (e.g., innovative therapies and biomarkers, cancer imaging and expanded population-based cancer research), enhanced research platforms (e.g., improved clinical research infrastructure and shared resources), increased efforts to build mission-related philanthropy, and expanded local-to-global partnerships.

PI_NAMEs: CAPITINI, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Acceleration;anti-cancer research;Area;Award;Biological Markers;Cancer Burden;cancer care;Cancer Center;Cancer Control;cancer genetics;cancer imaging;Cancer Model;cancer prevention;cancer therapy;Catchment Area;Clinical;Clinical Research;Communication;Communities;Comprehensive Cancer Center;Developmental Therapeutics Program;Diagnosis;Education;Ensure;Epigenetic Process;Equity;equity, diversity, and inclusion;evidence base;Faculty;Family;Funding;Goals;Grant;Growth;health care delivery;Human;Image;Immunologics;improved;Incidence;Individual;Infrastructure;innovation;Innovative Therapy;Institution;inter-institutional;Intervention;Journals;Knowledge;Leadership;Malignant Neoplasms;Manuscripts;medical schools;member;Minority Groups;Minority Participation;Mission;mortality;Names;Nature;next generation;Patients;Peer Review;Persons;Population;population based;Prevention;programs;Provider;Public Health;Publications;Publishing;Radiation;recruit;Research;Research Infrastructure;Research Personnel;Research Priority;Resource Sharing;Resources;Schools;Science;Services;Societies;Technology;Training;tumor microenvironment;Underrepresented Minority;Underserved Population;Universities;virology;Wisconsin;Work

PROJECT_TITLE: UW Comprehensive Cancer Center Support

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]