NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Contraception/Reproduction;Gene Therapy;Genetics;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Nanotechnology;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Pre-eclampsia is an obstetric condition that affects 5–8% of all pregnancies and is a leading cause of maternal mortality worldwide. Currently, no curative treatment options for pre-eclampsia exist. The goal of the proposed work is to develop a targeted, placenta-tropic lipid nanoparticle (LNP) platform for the delivery of therapeutic pro- angiogenic mRNA cargo to the placenta to treat pre-eclampsia during pregnancy.

PI_NAMEs: MITCHELL, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Address;Affect;Amyloidosis;angiogenesis;Angiogenic Factor;Anti-Hypertensive Agents;Antibodies;Anticonvulsants;associated symptom;Bar Codes;Blood flow;Blood Pressure;blood pressure control;blood vessel development;Cell Line;cell type;Cells;Clinical;clinical application;Clinical Treatment;COVID-19;curative treatments;cytokine;Decidua Basalis;design;Diffusion;Discipline of obstetrics;Disease;Disease Progression;DNA;Drug Delivery Systems;early onset;Encapsulated;Endothelial Cells;Engineering;Ensure;Enzyme-Linked Immunosorbent Assay;Excipients;Extrahepatic;fetal;Fetal Growth Retardation;Fetal health;Fetus;Formulation;Functional disorder;Goals;Health;high throughput screening;Histology;Human;Immunophenotyping;improved;In Vitro;in vivo;intravenous administration;Lead;lead candidate;Libraries;lipid nanoparticle;Lipids;Lipopolysaccharides;Liver;Lung;maternal hypertension;Maternal Mortality;Mediating;Messenger RNA;Microscopy;Modeling;Morbidity - disease rate;mortality;mouse model;mRNA delivery;mRNA Expression;multidisciplinary;Mus;nanoparticle delivery;Nature;next generation sequencing;NOS3 gene;novel;novel therapeutic intervention;novel therapeutics;nucleic acid delivery;Organ;PGF gene;Pharmaceutical Preparations;Phase;Placenta;Placenta Diseases;placental trophoblasts;Pre-Eclampsia;Prealbumin;preclinical study;Pregnancy;pregnant;prevent;Primary Cell Cultures;Protein Isoforms;Proteins;pup;RNA vaccine;screening;Seizures;Serum;Spiral Artery of the Endometrium;Spleen;stem;Structure;success;systemic inflammatory response;Therapeutic;therapeutic protein;therapeutic siRNA;Treatment Efficacy;trophoblast;Tropism;Uterus;Vascular blood supply;Vascular Endothelial Growth Factors;Vasodilation;Western Blotting;Work

PROJECT_TITLE: mRNA lipid nanoparticles for pre-eclampsia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (81)]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative In addition to core motor impairments, Parkinson's Disease often entails motivation-related symptoms such as apathy and depression. However, we lack a detailed understanding of the neural circuit interactions underlying how we select and perform effortful actions in the pursuit of our goals. By characterizing circuit mechanisms regulating the activity of different nigrostriatal dopamine projections and examining how these dopamine neuron subpopulations contribute to effortful reward-seeking behavior, this research program will yield critical new insights into the cell types and circuits supporting motivated behavior.

PI_NAMEs: HOLLON, NICK GARBER (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Ablation;Address;Anatomy;Basal Ganglia;Behavior;Behavior assessment;Behavioral;Bradykinesia;Caregivers;Cell Nucleus;cell type;Corpus striatum structure;Costs and Benefits;Data;Disease;Disease Progression;Dopamine;dopaminergic neuron;effective therapy;Evaluation;Exertion;Exhibits;experimental study;Fatigue;Fiber;Functional disorder;gamma-Aminobutyric Acid;genetic approach;genetic manipulation;Glutamates;Goals;Impairment;in vivo;insight;Knowledge;Learning;Measures;Mediating;Mental Depression;Midbrain structure;motivated behavior;Motivation;motor deficit;motor impairment;Movement;Mus;neural;neural circuit;Neurodegenerative Disorders;Neuromodulator;Neurons;non-motor symptom;novel;optogenetics;Outcome;Output;Parkinson Disease;pars compacta;Pathway interactions;Patients;Pattern;Photometry;Population;programs;Quality of life;Regulation;Research;response;Rewards;Role;segregation;sensor;Signal Transduction;Specificity;Stimulus;STN stimulation;Structure of subthalamic nucleus;Substantia nigra structure;Symptoms;Task Performances;Testing;tool;Tremor;Viral;Work

PROJECT_TITLE: Substantia nigra circuits in instrumental action

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Alcohol use disorder (AUD) is a serious health and societal problem, and development of better therapies is needed. This project investigates neuroanatomical mechanisms by which administration of oxytocin, a potential novel treatment of AUD, can mediate its effects on alcohol drinking. Understanding these mechanisms is important for the development of novel treatments of this disorder.

PI_NAMEs: RYABININ, ANDREY E (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: acamprosate;Address;Agonist;alcohol abuse therapy;alcohol and other drug;Alcohol consumption;alcohol craving;alcohol cue;alcohol use disorder;Alcohols;Anterior;Area;Attention;Binding;Birth;Blood;Brain;Cells;Clinic;Clinical;Clinical Research;cue reactivity;designer receptors exclusively activated by designer drugs;Development;Diagnosis;Disease;Disulfiram;Drug usage;Enterobacteria phage P1 Cre recombinase;experimental study;FDA approved;Female;Food;Genetic;Goals;Health;innovation;Intranasal Administration;intraperitoneal;Investigation;knock-down;Label;Lactation;LoxP-flanked allele;male;Measures;Mediating;men;Mus;Naltrexone;Nature;Neuroanatomy;Neurons;nonhuman primate;novel;novel strategies;olfactory bulb;olfactory nuclei;Olfactory Pathways;Oxytocin;Oxytocin Receptor;Patients;Penetration;Peptides;Permeability;Pharmaceutical Preparations;Pharmacotherapy;Placebos;preclinical study;preference;promoter;Public Health;receptor;Receptor Activation;Receptor Gene;Recombinant adeno-associated virus (rAAV);Recombinants;Regulation;Reporting;Research Personnel;Rodent;Rodent Model;Role;Route;Satellite Viruses;Social Behavior;System;Testing;Translating;Trigeminal nerve structure;United States;Vasopressin Receptor;Woman

PROJECT_TITLE: Olfactory targets of alcohol use disorder medications

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Clinical Research;Kidney Disease

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Hemodialysis is a lifeline for patients with kidney failure. Close to 50% of successful hemodialysis accesses develop frequent complications; however, the current imaging modality to diagnose such complications has several limitations. This grant proposes to examine an alternative imaging technique that is more sensitive, provides additional information on the nature of complication, and guides vascular interventions.

PI_NAMEs: CHITALIA, VIPUL C (contact);FARBER, ALIK ;GANGULI, SUVRANU

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: 3-Dimensional;Acceleration;accurate diagnosis;Address;Algorithms;Angiography;Applications Grants;Blood Vessels;candidate marker;Clinical;Clinical Research;clinically significant;Complication;Contrast Media;Data Analyses;deep neural network;Detection;Diagnosis;Diagnostic;Elasticity;End stage renal failure;Evaluation;experience;Functional disorder;Grant;Guidelines;Hemodialysis;hemodynamics;Image;imaging modality;Imaging Techniques;indexing;Intervention;Intravenous;Kidney Failure;Legal patent;Lesion;Maintenance;Measures;Medicare;Methods;Modality;Modeling;Morphology;Nature;Patients;Pilot Projects;point of care;predicting response;pressure;Primary Lesion;primary outcome;Procedures;radiological imaging;radiologist;Radiology Specialty;Research;Residual state;response;restenosis;Risk;Role;Safety;secondary outcome;Severities;Shapes;standard of care;Stenosis;Stretching;Surgeon;Texture;Therapeutic;Translating;translational scientist;two-dimensional;ultrasound;United States;Vascular Diseases;Work

PROJECT_TITLE: Role of Intravenous ultrasound (IVUS) in arteriovenous hemodialysis access dysfunction

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: Understanding of protein dynamics – and their relationship to protein sequence evolution – lags far behind understanding of stable protein structure despite the fact that few proteins could fulfill their biological functions effectively without specific dynamic properties. We have developed methods for real-time characterization of the functional dynamics of single molecules of a paradigmatic protein nanomachine in a family required for bacterial growth and pathogenesis. Our proposed studies will expand basic understanding of protein function and sequence evolution in a manner that can be applied to the development of new drugs modulating the function of dynamically active proteins and to the engineering of proteins to perform novel molecular activities of biomedical utility.

PI_NAMEs: HUNT, JOHN FRANCIS (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Active Biological Transport;Active Sites;Amino Acid Sequence;Amino Acids;Architecture;Area;ATP Hydrolysis;ATP phosphohydrolase;ATP-Binding Cassette Transporters;ATPase Domain;Automobile Driving;Back;Binding;Binding Sites;Biochemical;Biological Assay;Biological Process;biophysical analysis;biophysical techniques;Communities;Complex;conformational conversion;Coupling;Cryoelectron Microscopy;Crystallography;Cytoplasm;Development;Dissociation;Drug Modulation;Electrostatics;Environment;Escherichia coli;Evolution;experimental study;Family;frontier;Goals;Growth;Hydrolysis;Individual;insight;Knowledge;Life;Liposomes;Measurement;Mechanics;Mediating;member;Membrane;Methodology;Methods;Modeling;Molecular;Molecular Conformation;molecular dynamics;Molecular Machines;molecular mechanics;molecular size;Monitor;Movement;mutant;Mutate;Mutation;nanodisk;nanomachine;novel;novel strategies;novel therapeutics;Pathogenesis;periplasm;permissiveness;Phylogenetic Analysis;Planet Earth;Power stroke;Process;Property;protein complex;Protein Conformation;Protein Dynamics;Protein Engineering;protein folding;protein function;protein structure;Proteins;Reaction;reconstitution;reconstruction;Refractory;Relaxation;Research;Resolution;Role;Sampling;Sequence Analysis;Side;Signal Transduction;single molecule;single-molecule FRET;solute;structural biology;Structure;System;temporal measurement;Testing;Time;Transmembrane Domain;Transmembrane Transport;Transport Process;Transport Reaction;Visualization;Vitamin B 12;Work

PROJECT_TITLE: Protein sequence influence on single-molecule transport dynamics

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Precision Medicine;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE  The excess fluids removed from the lungs or abdomen of patients with malignant effusions could serve as substrates for liquid biopsy (i.e., molecular profiling of tumor cells in body fluids) to develop novel predictive biomarkers and discover drug targets to treat these frequent and devastating complications of metastatic breast cancer. UCSF investigators collaborated with Deepcell, a company that developed an artificial intelligence- assisted, morphology-based approach to isolate tumor cells away from the predominant immune cell populations in malignant effusions and successfully generated molecular profiles and morphology atlases of these cells. In this proposal, we expand this collaboration to validate the Deepcell platform and develop liquid biopsy tests to assess known actionable biomarkers and discover new ones, with a vision of transforming the treatment of malignant effusions from a palliative setting to a therapeutic opportunity.

PI_NAMEs: MAGBANUA, MARK JESUS (contact);MASAELI, MAHDOKHT ;ROSENBLUTH, JENNIFER M.

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Abdomen;Address;Antibodies;Artificial Intelligence;artificial intelligence model;Atlases;Biological Markers;biomarker development;biomarker discovery;biomarker validation;Body Fluids;Breast Cancer Patient;Breast Cancer therapy;cancer biomarkers;cancer cell;cancer therapy;Cell Fraction;Cell Separation;Cells;Cellular Morphology;Classification;Clinical;clinically relevant;clinically significant;Collaborations;Collection;Complex;Copy Number Polymorphism;Cytopathology;Data;Development;Diagnosis;Diagnostic;Disease;DNA;Drug Targeting;effusion;Epithelium;ERBB2 gene;ESR1 gene;Evaluation;Excision;exome sequencing;Fluorescence-Activated Cell Sorting;Fluorochrome;Gene Expression;Genes;Genetic Transcription;genomic aberrations;Genomic approach;Genomic DNA;genomic profiling;Heterogeneity;Image;Immune;immunocytochemistry;Immunooncology;improved outcome;In Vitro;Label;liquid biopsy;Liquid substance;Lung;magnetic beads;Malignant - descriptor;Malignant Breast Neoplasm;Metastatic breast cancer;Methods;Mining;Modality;Modeling;Molecular;molecular marker;Molecular Profiling;Monitor;Morbidity - disease rate;morphological criteria;Morphology;mortality;Mutate;Mutation;Neoplasm Circulating Cells;neoplastic cell;new therapeutic target;novel;novel marker;Organoids;palliating symptoms;palliation;palliative;patient response;Patient-Focused Outcomes;Patients;Performance;Phase;PIK3CA gene;Pilot Projects;Population;predicting response;predictive marker;Prognosis;protein expression;Research;Research Personnel;Resistance;response;response biomarker;Risk;RNA;Sampling;single-cell RNA sequencing;Site;Solid;Structure;Symptoms;Testing;Therapeutic;therapy resistant;Time;Tissue Banks;Tissues;tool;translational impact;treatment response;tumor;validation studies;Vision

PROJECT_TITLE: Developing liquid biopsy tests for malignant effusions using artificial intelligence-assisted, morphology-based isolation of tumor cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-E (57)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Pediatric;Prevention;Sleep Research

ORG_CITY: BOZEMAN

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: Project Narrative A pattern of shortened weekday sleep and weekend recovery sleep begins to emerge as early as 8 years of age and has been shown to blunt positive emotional experiences, increasing risk for mental health disorders. The present set of studies will provide a mechanistic understanding of how this sleep pattern produces acute and long-term changes in positive valence systems (PVS) in both social and non-social contexts during a period of increased reward sensitivity. Results will provide needed insight into sleep’s role in psychiatric risk during a period of the lifespan marked by rapid changes in socioemotional functioning, including actionable targets for future research and interventions.

PI_NAMEs: ALFANO, CANDICE A;PALMER, CARA A. (contact)

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: 8 year old;actigraphy;Acute;Address;Adolescence;Affect;Affective;Age;approach behavior;Arousal and Regulatory Systems;Behavior;Behavioral;Binding;biological sex;Brain region;Characteristics;Childhood;Code;Communities;Crossover Design;Data;design;Development;diaries;Early identification;Emotional;emotional experience;emotional functioning;Eye Movements;Female;Friends;gaze;Goals;Health;Height;Impairment;insight;Intervention;Jet Lag Syndrome;Knowledge;Laboratories;Learning;life span;Long-Term Effects;Longitudinal Studies;Maintenance;male;Measurement;Measures;Mediating;Mental Depression;Mental disorders;Methods;Modeling;Modification;Monitor;Mood Disorders;Motivation;National Institute of Mental Health;Neuronal Plasticity;neurophysiology;Participant;Pathway interactions;Pattern;peer;Physiology;Polysomnography;poor sleep;Positive Valence;preadolescence;Prevalence;Prevention;Process;Protocols documentation;Randomized;rapid eye movement;Recovery;REM Sleep;Reporting;Research;Research Domain Criteria;response;reward anticipation;Rewards;Risk;Role;Sampling;Series;Sleep;sleep behavior;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep health;sleep pattern;social;Social Behavior;social communication;Social Functioning;Social Interaction;Strategic Planning;Surveys;System;theories;Time;Visit;visual tracking;Youth

PROJECT_TITLE: Developmental Impacts of Sleep on Positive Valence Systems and Socioemotional Functioning during Pre-Adolescence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-H (02)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Digestive Diseases;Health Services;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Precision Medicine;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Gastrointestinal (GI) problems are among the most common concern reported by families of autistic children and youth, but efforts to understand the nuances of GI symptoms are stymied by a lack of longitudinal research using real-world clinical datasets. We will use a multimethod, participatory approach to: (1) qualitatively describe autistic people’s GI experiences throughout the lifespan; (2) quantitatively characterize GI symptom rates, presentations, trajectories, and responses to treatment among autistic children/youth using electronic health records (EHRs) from Children’s Hospital Los Angeles (CHLA) (with both structured data, e.g., diagnosis codes and prescriptions; and unstructured data, i.e., keywords extracted from clinical notes via natural language processing); and (3) build predictive models of risk of GI symptom profiles and response to treatment using both traditional and machine learning approaches. By using longitudinal analyses and real-world clinical data, the proposed study provides a more nuanced prediction of GI symptom profiles and response to treatment, and holds promise for informing future targeted interventions to improve care for autistic individuals.

PI_NAMEs: ANGELL, AMBER M. (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Accident and Emergency department;Address;adolescent with autism spectrum disorder;adult with autism spectrum disorder;Advocacy;Age;Age of Onset;Alternative Health;autism community;autism spectrum disorder;autistic;autistic children;Behavioral;Behavioral Symptoms;Caregivers;Caring;Child;Clinical;Clinical Data;Clinical Treatment;Code;cohort;Collaborations;community advisory board;Data;Data Collection;Data Set;Diagnosis;Diagnostic;Diet;disparity reduction;Dreams;Electronic Health Record;Emergency Care;Equity;experience;Family;Future;gastrointestinal;Gastrointestinal Diseases;gastrointestinal symptom;Health;health care service utilization;Health Services Research;high risk;improved;indexing;individuals with autism spectrum disorder;Intervention;Interview;Knowledge;Label;Life;life span;Lived experience;longitudinal analysis;Los Angeles;Machine Learning;machine learning prediction;Measures;medical specialties;Mental Health;Methods;Natural Language Processing;Non-Prescription Drugs;Parents;Pediatric Hospitals;person centered;personalized medicine;physical conditioning;Population;predicting response;Predictive Factor;Prevalence;Procedures;Quality of life;Reporting;Research;Research Methodology;response;Review Literature;Risk;Risk Assessment;risk prediction;risk prediction model;Services;sex;Sleep;social;sociodemographics;standard of care;structured data;Subgroup;Symptoms;Time;treatment response;unstructured data;Work;Youth

PROJECT_TITLE: Characterizing gastrointestinal disorder trajectories for autistic sub-groups: Machine learning prediction of risk profiles and response to treatment

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Columbus

ORG_DEPT: PATHOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This proposal aims to elucidate the novel role of S100A7 signaling in enhancing immune evasive mechanisms, especially in African American (AA) triple-negative breast cancer (TNBC) patients. In addition, these studies will determine if S100A7 and its downstream signaling molecules could be used as novel therapeutic targets and prognostic biomarkers for AA TNBC using different pre-clinical mouse models and patient samples. These studies will also provide novel insights for developing innovative immune-based therapies against aggressive and metastatic TNBC observed in AA women.

PI_NAMEs: GANJU, RAMESH K. (contact)

PROJECT_TERMS: Abraxane;Affect;African American;African American Women;aggressive breast cancer;anti-CTLA-4 therapy;anti-CTLA4;anti-tumor immune response;Automobile Driving;Breast Cancer Cell;Breast Cancer cell line;breast cancer diagnosis;Breast Cancer Patient;breast cancer progression;Cancer Burden;caucasian American;Caucasians;CD8-Positive T-Lymphocytes;Cell Line;Cell Physiology;Cells;Clinical;clinically relevant;Data;Death Rate;design;Dinoprostone;Down-Regulation;Elements;Ethnic Population;Event;Exhibits;Fostering;FOXP3 gene;Future;Generations;Genes;Genetic Engineering;Genetically Engineered Mouse;Growth;high dimensionality;high risk population;IFNGR1 gene;Immune;Immune checkpoint inhibitor;Immune Evasion;Immune signaling;Immunologics;Immunosuppression;Immunotherapy;improved outcome;in vivo;Incidence;Infiltration;innovation;insight;Interferon Type II;Investigation;Knock-out;Knockout Mice;Macrophage;Malignant Breast Neoplasm;Mediating;Microscopy;Modeling;Molecular;mouse model;Nature;Neoplasm Metastasis;neoplastic cell;neutralizing antibody;new therapeutic target;novel;novel therapeutics;Oncogenic;Organoids;orthotopic breast cancer;Outcome;overexpression;Pathogenesis;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Phenotype;pre-clinical;Pre-Clinical Model;preclinical study;Process;Prognosis;prognosis biomarker;Prognostic Marker;prognostic significance;programmed cell death ligand 1;Proteins;racial disparity;recruit;Regulation;Regulatory T-Lymphocyte;Research;Role;S100A7;Sampling;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;Spatial Distribution;T-Lymphocyte;targeted biomarker;Therapeutic;therapeutic biomarker;Therapeutic Intervention;Time;Transgenic Mice;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;Tumor Burden;tumor microenvironment;Tumor Subtype;Tumor Tissue;Tumor-associated macrophages;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Up-Regulation;White Women

PROJECT_TITLE: Unravel the novel role of S100A7 and its functional partners in Metastatic Triple Negative Breast Cancer Racial Disparity

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Human Fetal Tissue;Immunotherapy;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

PHR: PROJECT NARRATIVE The unresolved question of how the fetus and placenta avoid being rejected by the maternal immune system has major implications for understanding potential disorders of human pregnancy such as spontaneous abortion and preeclampsia. Capitalizing on recent work demonstrating the potent immune-modulatory function of the carbohydrate structures that decorate placental proteins, this proposal seeks to gain insight into how these structures suppress maternal immune responses both systemically and locally, within the pregnant uterus. We anticipate our work will also foster application of underlying mechanisms to immune tolerance induction in the clinical arena.

PI_NAMEs: ERLEBACHER, ADRIAN  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Address;Affect;Affinity;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Antigens;Area;Avidity;Awareness;B-Lymphocytes;Bathing;Behavior;Binding;Biochemical;Blood;brush border membrane;carbohydrate structure;CD22 gene;CD4 Positive T Lymphocytes;Cells;Circulation;Clinical;Complement;Complement Activation;Conceptus;congenital infection;Data;Decidua;Deposition;Discipline of obstetrics;Disease;Engineering;experimental study;fetal;Fetal Growth Retardation;Fetus;Fingerprint;Follicular Dendritic Cells;Fostering;Glycobiology;Glycoproteins;glycosylation;Goals;Host Defense;Human;human model;Immune;Immune response;Immune Tolerance;Immunoglobulin M;Immunosuppression;Immunotherapeutic agent;In Vitro;Infection;insight;Investigation;Knowledge;Laboratories;Link;lymph nodes;Mass Spectrum Analysis;maternal immune system;Maternal-Fetal Exchange;Mediating;Membrane;Membrane Proteins;microbiome;microbiota;Modeling;mouse model;Mus;natural antibodies;Nature;Ovalbumin;Pathogenesis;Pathway interactions;Placenta;Play;Polysaccharides;Positioning Attribute;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy immunology;Pregnancy Outcome;Pregnancy Proteins;pregnant;Pregnant Uterus;Premature Labor;prevent;Productivity;Property;Reaction;receptor;Regulation;Reproductive Immunology;response;Role;scaffold;sialic acid binding Ig-like lectin;sialylation;Spleen;Spontaneous abortion;Structure;Structure of germinal center of lymph node;Syncytiotrophoblast;System;T-Lymphocyte;Techniques;Testing;Therapeutic;tissue resident memory T cell;Tissues;trophoblast;Work

PROJECT_TITLE: Glycan regulation of fetomaternal tolerance

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 HSC-X (M1)]


ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: In response to PAR 23-122, this application encompasses both Scientific and DEIA Aims. Scientifically, it revolves around elucidating the substrate specificity of a newly discovered helical motif in substrates of the PP2A/B55α phosphatase. Simultaneously, it aims to implement a comprehensive Fels Biomedical Research URM Undergraduate Training Program (Fels-BR-U2) tailored for Temple University (TU) undergraduates from historically underrepresented (HUR) groups.

PI_NAMEs: GRANA, XAVIER  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Admission activity;alpha helix;Alzheimer's Disease;Amino Acid Motifs;Amino Acid Sequence;Amino Acids;Binding;bioinformatics pipeline;Biological Assay;Biomedical Research;career;Catalogs;Catalytic Domain;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell model;Cell Physiology;Charge;Communication;Competence;Consensus;deep learning;Disease;Doctor of Philosophy;Electrostatics;Experimental Designs;Family member;Fellowship;gain of function;Genetic;Goals;graduate school;Holoenzymes;Hydrophobic Interactions;In Vitro;inhibitor;Instruction;Interphase;Knowledge;Length;Link;loss of function;Malignant Neoplasms;Mediating;Mentors;Methods;minority undergraduate;Molecular;mutant;new therapeutic target;Oral;Pathway interactions;Peptides;Phosphoric Monoester Hydrolases;Phosphorylation;Positioning Attribute;Professional Competence;programs;protein aminoacid sequence;Protein Dephosphorylation;Protein Engineering;Protein Region;Protein Serine/Threonine Phosphatase;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Readiness;recruit;Research;response;Retinoblastoma Protein;Role;Scaffolding Protein;Scheme;Science;Signal Transduction;skills;Structure;Students;Substrate Specificity;success;Surface;Surface Plasmon Resonance;Technical Expertise;Testing;Therapeutic Intervention;Training;Training Programs;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Universities;Validation;Work;Writing

PROJECT_TITLE: PP2A/B55alpha substrate specificity and function in cell cycle progression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-G (56)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE The proposed project aims to comprehensively measure Aβ42/40 and phosphorylated tau species in plasma from the Health and Aging Brain Study-Health Disparities (HABS-HD) study. The overarching hypothesis of this project is that plasma biomarkers related to AD pathology present differently among diverse populations and as a result have different relations to established clinical outcomes such as PET amyloid levels and cognitive outcomes. To test this hypothesis, we propose to characterize plasma p-tau217 and Aβ42/40 in Mexican Americans, AA and non-Hispanic white populations of the HABS-HD study.

PI_NAMEs: PETERSEN, MELISSA ;RISSMAN, ROBERT  (contact);WINSTON, CHARISSE N

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Acceleration;African American;African American population;aging brain;Algorithms;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Amyloidosis;Area;biobank;Biological Assay;Biological Markers;biomarker development;Clinical;clinical trial recruitment;Clinical Trials;Cognition;Cognitive;cognitive function;cohort;Cohort Studies;Collaborations;Communities;comorbidity;Data;Data Set;deprivation;Development;Diagnostic;differential expression;early onset;ethnic diversity;Ethnic Origin;Ethnic Population;Funding;Genotype;Health;health disparity;Hispanic Americans;Hispanic Populations;Impaired cognition;improved;indexing;Individual;Link;Longitudinal Studies;Mass Spectrum Analysis;Measures;Medical;Mexican Americans;Modeling;Nerve Degeneration;Neurofibrillary Tangles;Not Hispanic or Latino;novel;novel marker;Outcome;Participant;PET positivity;Phenotype;Plasma;Population;population health;Population Heterogeneity;Populations at Risk;Positron-Emission Tomography;predictive marker;predictive modeling;Process;protein biomarkers;Publishing;Race;racial population;Risk;Sampling;screening;Screening procedure;sex;Site;specific biomarkers;Specificity;Symptoms;tau Proteins;tau-1;Testing;Underserved Population;United States National Institutes of Health;Update;Visit;Work

PROJECT_TITLE: Impact of Ethnicity on the Utility of Plasma Amyloid and Tau to Predict Alzheimer's Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Organ Transplantation;Transplantation

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative This proposal follows up on our robust finding that mineralocorticoid receptor (MR) antagonism can greatly improve donor heart function and ischemic tolerance. We also show that cardiac preservation is associated with increased MR expression and its organization into molecular condensates or clusters. Our proposal will clarify how MR condensates form and if dampening MR signaling can improve heart function in pigs and human heart which can ultimately improve heart transplant outcomes.

PI_NAMEs: TANG, PAUL  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acetylation;antagonist;Biology;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cell Death;Cells;Cessation of life;Chromatin;Chronic;Clinical;Clinical Trials;Cloning;cold temperature;Combined Modality Therapy;Coupled;Crowding;Cryopreservation;Data;Dependovirus;Disease;DNA Binding Domain;efficacy evaluation;Enhancers;Environment;Evaluation;Event;Evolution;Family suidae;Fibrosis;Future;Genetic Transcription;Geography;Goals;graft dysfunction;HDAC4 gene;Heart;Heart failure;heart function;Heart Hypertrophy;heart preservation;Heart Transplantation;Histidine;Histone Deacetylase;Histone Deacetylase Inhibitor;Hour;Human;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;interest;Kidney;Kidney Failure;Knowledge;Length;Ligand Binding Domain;Ligands;Liver;liver injury;Maintenance;Malignant Neoplasms;Mechanics;Mediating;Mediator;Medical;member;Mineralocorticoid Receptor;Modeling;Molecular;mouse model;Mus;mutant;Myocardial dysfunction;Myocardial Infarction;Myocardial Ischemia;Neonatal;neuropathology;novel;Nuclear;Nuclear Receptors;Organ;organizational structure;Outcome;Output;Oxidative Stress;Pathway interactions;Patients;Perfusion;pharmacologic;Phase;Physical condensation;Play;Population;pre-clinical;preservation;Process;promoter;protein expression;Proteins;receptor;receptor expression;Receptor Inhibition;Receptor Signaling;reconstitution;Refractory;Reperfusion Therapy;Research;Resources;response;Response Elements;Risk;Role;Signal Transduction;single-cell RNA sequencing;Solid;Stroke;Structure;Temperature;three dimensional structure;Time;transcription factor;Translations;transplant model;Transplantation;Treatment Failure;Tryptophan;Valproic Acid;Waiting Lists

PROJECT_TITLE: Targeting Mineralocorticoid Receptor Condensates to Optimize Donor Heart Preservation

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Extensive research efforts have led to substantial advances in our understanding about how the brain regulates the eating termination due to meal-induced satiety, but the role of sensory inputs in feeding regulation, such as olfactory cues of food, is under-studied. We will investigate whether the brain circuit involving three nodes, namely the olfactory bulb (OB), ventral subiculum (vSub) and ventral medium hypothalamus (VMH), regulates food-derived odor-suppressed food intake. These studies will start to reveal the neurobiological mechanisms of this novel concept that olfactory signals prevent overeating, and may identify rational targets for the development of novel therapeutic approaches to combat obesity.

PI_NAMEs: HE, YANG  (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Address;adult obesity;Animals;Attenuated;Body Weight;Brain;Centers for Disease Control and Prevention (U.S.);Child;Chocolate;Chronic;combat;Cues;Data;Desire for food;Development;Diabetes Mellitus;diet-induced obesity;Disease;Drosophila genus;Eating;Eating Behavior;Eating Disorders;effective therapy;Energy Metabolism;Epidemic;Esthesia;Etiology;Exhibits;Exposure to;feeding;Feeding behaviors;Fiber;Food;food consumption;Food Intake Regulation;FOS gene;Future;gain of function;Genetic;Genetic Recombination;Glutamates;Goals;Health;Heart Diseases;High Fat Diet;Homeostasis;Human;human disease;Hunger;Hyperphagia;Hypothalamic structure;innovation;Intake;Link;Long-Term Effects;loss of function;Malignant Neoplasms;Maps;Mediating;Mission;Modeling;Molecular;mortality;Mus;neural circuit;Neural Pathways;neurobiological mechanism;Neurons;novel;novel therapeutic intervention;novel therapeutics;Obesity;obesity prevention;Odors;olfactory bulb;optogenetics;Photometry;Physiological;Play;Population;prevent;Public Health;reduced food intake;Regulation;Reporting;Research;response;Risk;Role;Satiation;Savory;sensory input;Signal Transduction;single-cell RNA sequencing;Smell Perception;statistics;Stroke;Synapses;Techniques;Testing;therapeutic target;Time;transcriptomics;United States National Institutes of Health;Vinegar;Weight;Weight Gain;Woman;Yeasts

PROJECT_TITLE: Targeting olfactory neural pathways to combat obesity

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE The basal forebrain (BF) plays a pivotal role in regulating cortical activity and plasticity to support vital cognitive functions such as attention. Recent findings have prompted a re-evaluation of the role of its cholinergic neurons in attention, shifting the focus to alternative circuits. We propose study a major cortex-projecting inhibitory projection: parvalbumin-expressing GABAergic neurons (BF-PV). Our research will uncover the neural circuitry and computations behind sustained attention, providing insights into the basal forebrain's role in cognition and inform therapeutic avenues for attention disorders and BF-linked dementias.

PI_NAMEs: KEPECS, ADAM  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Acetylcholine;Alzheimer's Disease;Anatomy;Arousal;Attention;attentional control;attentional modulation;Auditory;Axon;basal forebrain;basal forebrain cholinergic neurons;Behavior;behavior prediction;Behavioral;Brain;cell type;cholinergic;cholinergic neuron;Cognition;Cognitive;cognitive function;Computer Models;Cues;Data;Dementia;design;Detection;Disease;Disinhibition;Evaluation;expectation;experimental study;Faculty;Goals;Impaired cognition;improved;in vivo;inhibitory neuron;insight;Interneurons;Investigation;Knowledge;Learning;Link;Maps;Mediating;Methods;Motivation;Mus;neural;neural circuit;Neurons;neurotransmission;new therapeutic target;optogenetics;Output;Parkinson Disease;Parkinson's Dementia;Parvalbumins;Pathway interactions;Pattern;Performance;Physiology;Play;Population;Positioning Attribute;Psychological reinforcement;Reaction Time;Research;response;Role;Sensory;Signal Transduction;Sleep;Stimulus;sustained attention;Technology;Testing;theories;Therapeutic;Viral;Work

PROJECT_TITLE: Basal Forebrain Non-cholinergic Circuit Mechanisms of Sustained Attention

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Few children with recurrent neuroblastoma survive, so we have developed a molecule that binds to ROR1 on neuroblastoma and to CD3 on T cells causing the T cells to kill the cancer cells. Because nearby cancer cells will upregulate a protein called PD-L1 to escape immune surveillance, we also included a PD-L1 binder so that the T cells will kill the cancer cells that are trying to escape. We propose to test this molecule in multiple patient-derived neuroblastoma models, including those with heterogeneous ROR1 expression to determine whether this molecule should advance toward human clinical trials.

PI_NAMEs: OLSON, JAMES M (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Address;Adult;Binding;Biological Assay;Bispecific Antibodies;cancer cell;Cancer Control;cancer stem cell;cancer type;CAR T cell therapy;CD3 Antigens;Cell Death;cell killing;Cell Line;Cell Therapy;Cells;Child;Childhood;Childhood Solid Neoplasm;chimeric antigen receptor T cells;clinical development;Clinical Trials;Coculture Techniques;Consensus;cost;Coupled;Creativeness;Data;Defense Mechanisms;design;Disease remission;Dose;Educational process of instructing;efficacy evaluation;Embryonic Development;Engineering;Ewings sarcoma;Exploratory/Developmental Grant;Exposure to;Failure;Future;Glioblastoma;Grant;Heterogeneity;Human;human tissue;Immune checkpoint inhibitor;Immunologic Surveillance;immunological synapse formation;Immunologics;Immunotherapy;in vitro testing;in vivo;innovation;Interferon Type II;Investigational Drugs;Investments;Light;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;manufacture;MDA MB 231;Measures;migration;Modeling;Neuroblastoma;neuroblastoma cell;novel;novel strategies;novel therapeutics;Osteosarcoma;Patients;Pediatric Neoplasm;Phenotype;Play;programmed cell death ligand 1;programs;Proteins;Receptor Protein-Tyrosine Kinases;Recurrence;resistance mechanism;Resources;response;Rhabdomyosarcoma;Role;ROR1 gene;single molecule;Solid Neoplasm;stem;success;T cell therapy;T-Cell Activation;T-Lymphocyte;T47D;Testing;Therapeutic;Time;Tissues;Toxic effect;tumor;tumor heterogeneity;tumor initiation;Up-Regulation;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Assessing the efficacy of a ROR1:PD-L1:CD2 multispecific T cell engager in ROR1-positive and -negative neuroblastoma models

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (M1)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PHR: Project narrative Our goal is to decipher how neural circuits in the orbitofrontal cortex support adaptive decision-making and generate choice biases. We propose that different subcortical projections of orbitofrontal cortex have specialized roles, each transmitting specific information and influencing particular choice biases. This has crucial implications for understanding brain malfunctions and informing circuit-specific therapeutics for drug abuse disorders.

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Algorithms;Anatomy;Area;Behavior;behavior influence;Brain;cell type;Cells;Choice Behavior;Complex;Computer Analysis;Computer Models;Data;Decision Making;decision making algorithm;Dimensions;Disease;Drug abuse;Drug Addiction;Drug user;Economics;experience;Functional disorder;genetic manipulation;Goals;Image;insight;Learning;Link;Maps;Measures;Mediating;Methods;Molecular;Monitor;neural;neural circuit;Neurons;neurotransmission;optogenetics;Outcome;Output;Pharmaceutical Preparations;Pilot Projects;Positioning Attribute;Process;Rattus;Regional Anatomy;Reporting;response;Rewards;Role;Route;Structure;Substance abuse problem;Testing;Therapeutic;Time;transcriptome sequencing;transmission process;Ventral Striatum;Ventral Tegmental Area;Viral

PROJECT_TITLE: Functions of Target-Defined Orbitofrontal Neuron Types in Decision Making


NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE. The proposed research is relevant to public health because it seeks to identify the unique signatures underlying the potent effect of the calcium-activated phosphatase calcineurin (CN) on acute pancreatitis (AP), which is a major public health problem that has limited therapeutic modalities. In the current proposal, we will firstly map key signaling pathways that are modulated by CN in AP and secondly identify novel CN substrates within these pathways. The proposal is relevant to the NIH mission relating to the application of knowledge to enhance health and reduce illness and disability.

PI_NAMEs: CYERT, MARTHA S.;HUSAIN, SOHAIL Z (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Acinar Cell;Acinus organ component;acute pancreatitis;Affinity;Autophagocytosis;Autophagosome;Binding;Biochemical;biochemical tools;Biogenesis;Bioinformatics;Caerulein;Calcineurin;Calcineurin inhibitor;Calcineurin Pathway;calcineurin phosphatase;Calcium;Cells;Clinical;Communities;Computing Methodologies;Coupled;Coupling;Data;design;disability;Disease;Environment;Exposure to;FK506;Genes;Goals;Health;Human;Impairment;in vivo;inhibition of autophagy;inhibitor;innovation;Knowledge;Life;Maps;Mediating;Mediator;Methods;Mission;Modality;Modeling;Molecular Probes;Molecular Profiling;Morbidity - disease rate;multidisciplinary;Mus;Mutate;novel;Pain;Pancreas;Pancreatitis;Pathway interactions;Phosphopeptides;phosphoproteomics;Phosphorylation;pressure;Process;Proteins;prototype;Public Health;Regulation;Research;Research Personnel;Resources;Role;Severity of illness;side effect;Signal Pathway;Signal Transduction;Specimen;targeted treatment;Technology;Testing;Therapeutic;Therapeutically Targetable;United States National Institutes of Health;Validation

PROJECT_TITLE: Elucidating novel mechanisms for pancreatitis through calcineurin signaling

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: Aurora

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative The goal of this application is to train outstanding physician scientists in otolaryngology who will contribute to cutting edge science in the field and drive advancements in patient care. Support is requested for in- depth research training and mentoring for residents and medical students.

PI_NAMEs: AGRAWAL, YURI ;KINNAMON, SUE C. (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Admission activity;Area;career;career development;Clinical;Collaborations;Colorado;Communication impairment;Communities;Dedications;Development Plans;Education;Environment;Equilibrium;Ethics;experience;Faculty;Fostering;Funding;Future;Goals;Grant;Head and Neck Cancer;Hearing;innovation;Language;Medical;medical schools;medical specialties;Medical Students;Mentors;National Institute on Deafness and Other Communication Disorders;novel strategies;Otolaryngology;Patient Care;Physicians;programs;recruit;Research;Research Methodology;Research Personnel;Research Training;Residencies;Science;Scientist;skills;Smell Perception;Speech;Structure;Taste Perception;Teacher Professional Development;Training;Training Programs;Universities

PROJECT_TITLE: Colorado Clinician Scientist Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Z (43)]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: NARRATIVE Maladaptive avoidance is prominent in depression, anxiety, posttraumatic stress disorder, and obsessive- compulsive disorder. This project seeks to determine the role of dopamine in promoting the neural transformations that occur in prefrontal cortex during avoidance learning. Our research will reveal key loci of potential dysfunction and therapeutic intervention in psychiatric disorders.

PI_NAMEs: DENARDO, LAURA ANNE (contact);WILKE, SCOTT ALLEN

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Adaptive Behaviors;Address;Animals;Anxiety;approach behavior;Aversive Stimulus;avoidance behavior;Avoidance Learning;Behavior;Behavioral;Brain;cell type;Characteristics;Cognitive;conditioned fear;Corpus striatum structure;cost;Cues;design;Disease;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;dopaminergic neuron;DRD2 gene;effective therapy;Emotional;Etiology;Evaluation;Event;Exhibits;experimental study;Fiber;flexibility;foot;Functional disorder;Goals;Head;Image;Individual;innovation;Interneurons;Intervention;Learning;Link;Location;Measurement;Measures;Medial;Mediating;Mental Depression;Mental disorders;Methods;Microscope;miniaturize;Modeling;Mus;neural;Neurobiology;Neurons;novel;Obsessive-Compulsive Disorder;opportunity cost;Optics;optogenetics;Outcome;Pathologic;Pattern;pharmacologic;Photometry;Population;Post-Traumatic Stress Disorders;preempt;Prefrontal Cortex;Presynaptic Terminals;Process;Productivity;Pyramidal Tracts;Research;Role;Safety;sensor;Shapes;Shock;Signal Transduction;spatiotemporal;targeted treatment;Testing;Therapeutic Intervention;Time;tool

PROJECT_TITLE: Role of prefrontal dopamine circuits in threat avoidance learning

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Autism spectrum disorder and neurodevelopmental delay (ASD/NDD) are complex conditions, and although many different genes have been implicated in their etiology, no clear molecular mechanism that leads to these conditions has been identified. We propose to integrate molecular technologies as well as patient datasets to holistically map how 72 genes associated with ASD/NDD impact brain function, seeking shared points of convergence between these genes. Our results will dramatically expand our understanding of how loss-of- function of risk genes mechanistically contributes to ASD/NDD, provide a framework for large-scale interrogation of gene function in the brain, and potentially identify common points of molecular dysregulation leading to ASD/NDD.

PI_NAMEs: JIN, XIN  (contact);LEVIN, JOSHUA ZVI

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Anatomy;ATAC-seq;autism spectrum disorder;Brain;Brain Diseases;Brain region;cell motility;Cell Nucleus;cell type;Cells;Chromatin;Complex;Corpus striatum structure;Data;data integration;Data Set;Development;Disease;Embryo;Epigenetic Process;epigenome;Etiology;Future;Gene Expression;gene function;gene regulatory network;Genes;Genetic;Genetic Screening;Genetic Transcription;genetic variant;genome sequencing;genome-wide;Genomics;Goals;Human;Human Genetics;Image;in vivo;insight;Lead;Light;Location;loss of function;loss of function mutation;Maps;Measurement;Methods;Molecular;Molecular Profiling;Morphology;multimodality;Neighborhoods;Neocortex;neocortical;neural circuit;neural network;neurodevelopment;Neurons;neuropsychiatry;Neurosciences Research;Organ;Pathogenesis;Pathologic;Pathway interactions;patient stratification;Patients;Phenotype;Regulation;Resolution;risk variant;RNA;screening;single cell genomics;single nucleus RNA-sequencing;Site;spatial integration;spatial relationship;Synapses;System;targeted treatment;Technology;Therapeutic;therapeutic development;Time;tool;transcriptome;Viral;Work

PROJECT_TITLE: Scalable functional analysis of neuropsychiatric risk genes with spatially integrated in vivo Perturb-seq

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (57)]


PHR: PROJECT NARRATIVE  The public frequently perceives vaping e-cigarettes as being less harmful than smoking cigarettes. However, it has become clear that vaping involves a lot of the same cardiovascular risk as smoking. The proposed project will investigate the cardiovascular effects of dual use of e-cigarettes and cigarettes on the human, rat, and cellular levels, focusing on whether dual use increases, decreases, or has the same harmful cardiovascular effects as exclusive use of either product.

PI_NAMEs: SPRINGER, MATTHEW LAWRENCE (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Address;Adverse effects;Animals;Attenuated;Biological Markers;Blood Vessels;Cardiac;cardiovascular effects;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cigarette;cigarette smoking;circulating biomarkers;Disparate;Electronic cigarette;electronic cigarette use;Emerging Tobacco Products;Endothelial Cells;endothelial dysfunction;Endothelium;Exhibits;Exposure to;Funding;General Population;Goals;Grant;Harm Reduction;Health;Health Benefit;heart function;heated tobacco products;Human;Impairment;improved;Individual;Inflammation Mediators;Inhalation;interest;Liquid substance;Literature;Logic;Marketing;Measures;Modified Risk Tobacco Product;Nicotine;nicotine inhalation;Nitric Oxide;Outcome;Pattern;Permeability;Physiological;Platelet aggregation;Production;Property;Rattus;Regulation;Research;Risk;Serum;Smoker;Smoking;smoking cessation;specific biomarkers;stem;Tobacco;Tobacco Industry;tobacco products;tobacco regulatory science;Tobacco use;Toxic effect;vaper;vaping

PROJECT_TITLE: Cardiovascular Effects of Inhalable Tobacco Product Dual Use

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-E (56)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: IRVINE

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Narrative There is a critical need to increase vaccine acceptance, especially among populations with health disparities, including Black and Latinx populations. As new types of vaccines are developed and released, it becomes increasingly important to understand the multi-level factors (including social media and social networks) that affect vaccine acceptance among these populations. This application seeks to use a novel approach to recruit participants and study these factors as well as to build a visualization tool that can be used by researchers and health departments. This project is being conducted in collaboration with the National Academies of Sciences, Engineering, and Medicine (NASEM), along with a team of scientists from a recent NASEM report, in order to improve likelihood of broadly translating and implementing the findings throughout public health.

PI_NAMEs: YOUNG, SEAN  (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Address;Adult;Affect;African American;American;Artificial Intelligence;artificial intelligence method;artificial intelligence model;Attitude;Behavior;Behavioral;Belief;Black Populations;Black race;Characteristics;Collaborations;combat;Communicable Diseases;Communication;Communities;contextual factors;COVID-19;COVID-19 pandemic;COVID-19 vaccine;Data;data visualization;digital;digital data;digital delivery;digital health;digital tool;disinformation;distrust;Education;Engineering;Enrollment;Exposure to;Family;follow-up;Foundations;Frequencies;Friends;Future;Geography;Graph;Health;health data;health disparity;health inequalities;health literacy;health organization;Health Services Accessibility;Healthcare Systems;Hearing;HIV;improved;Individual;Influentials;insight;Intervention;Knowledge;Latinx;Latinx population;Learning;Letters;Location;low health literacy;Maps;Medical;Medicine;member;Mental Health;Misinformation;Muslim religion;novel strategies;Outcome;Participant;Patient Recruitments;peer;Perception;Persons;Play;Politics;Population;prevent;Prevention;Public Health;Recommendation;Recording of previous events;Reporting;Research;Research Personnel;resilience;Role;role model;SARS-CoV-2 transmission;Science;Scientist;Sexually Transmitted Diseases;social influence;social media;Social Network;social stigma;Stigmatization;structural determinants;tool;Translating;Trust;Twitter;United States National Academy of Sciences;Vaccinated;Vaccination;vaccine acceptance;Vaccine Clinical Trial;vaccine development;vaccine hesitancy;Vaccines;Visualization;Visualization software;willingness;Work

PROJECT_TITLE: Influence of Social Media, Social Networks, and Misinformation on Vaccine Acceptance Among Black and Latinx Individuals

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Narrative In 2016, Dengvaxia, the first licensed dengue virus (DENV) vaccine, was administered to >830,000 school- aged Filipino children without prior serological testing. Subsequently, DENV-seronegative children who received Dengvaxia developed severe disease after breakthrough DENV infection (BTDI) and the efficacy of Dengvaxia waned over time, underscoring a critical need for an in-depth understanding of antibody and T-cell responses following Dengvaxia vaccination. In collaboration with the Research Institute for Tropical Medicine Philippines, we will determine the baseline DENV serostatus of Dengvaxia recipients to assess the long-term safety and effectiveness of Dengvaxia, and characterize humoral and T-cell responses induced by Dengvaxia prior to and after BTDI.

PI_NAMEs: WANG, WEI-KUNG  (contact)

PROGRAM_OFFICER_NAME: GALIVO, FEORILLO HERRERA

PROJECT_TERMS: Acute;aged;anthrax toxin;Antibodies;Antibody Response;Antibody titer measurement;Attenuated;Biological Assay;Blood;burden of illness;Capsid;CD8B1 gene;Child;cohort;Collaborations;Data;Dengue;Dengue Fever;Dengue Infection;Dengue Vaccine;Dengue Virus;Dengvaxia;Development;Disease;Disease Outcome;Dose;Effectiveness;efficacy trial;Enrollment;Enzyme-Linked Immunosorbent Assay;Enzymes;experimental study;Fever;Filipino;Goals;Hawaii;Health care facility;high risk;Human;Immune;Immune response;Immunization Programs;immunogenicity;Immunoglobulin G;Immunoglobulin M;Immunosorbents;Individual;Infection;Inferior;innovation;insight;Interferon Type II;Knowledge;lethal factor;Licensing;Link;Long-Term Effects;Manufacturer;Mass Vaccinations;Measures;mosquito-borne;N-terminal;neutralizing antibody;next generation;Nonstructural Protein;Participant;Philippines;Population;Proteins;Recommendation;Regimen;Research;Research Institute;Reverse Transcriptase Polymerase Chain Reaction;Risk;Risk Assessment;Safety;Sampling;School-Age Population;Schools;Serology test;seropositive;Serotyping;severe dengue;Spottings;Structural Protein;Surveillance Program;T cell response;Testing;Time;TNF gene;Tropical Medicine;Universities;Vaccinated;Vaccination;vaccine efficacy;Vaccinee;Vaccines;Virus Diseases;Yellow Fever;Yellow fever virus

PROJECT_TITLE: Long-term safety and effectiveness of Dengvaxia in the Philippines

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Substance Misuse;Transplantation

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: PROJECT NARRATIVE A major hurdle in developing effective neurological treatments has been translation of scientific discoveries from rodent models to humans. To close this critical translational gap, we will use 3D organoid- and marmoset tissue- derived-tools to explore ARX-associated mutations linked to cortical malformation, epilepsy, and intellectual disability. The overarching goals of this project are to develop a marmoset model system to represent the neurobiology of the human brain to advance the utility of the marmoset model to benefit the brain health research community.

PI_NAMEs: HERMANN, BRIAN PETER (contact);HSIEH, JENNY ;MCCARREY, JOHN R;NAVARA, CHRISTOPHER

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Alleles;Allogenic;Anatomy;Animals;Area;Behavioral Assay;Biological Models;bisulfite sequencing;Brain;Brain Diseases;brain health;brain research;Breeding;Callithrix;Callithrix jacchus jacchus;cell cortex;Cell Transplantation;cell type;Cells;Chimerism;Chromatin;Clinic;clinical predictors;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cognitive process;Communities;Complex;Cortical Malformation;CRISPR/Cas technology;Defect;Derivation procedure;design;Development;differentiation in vitro;disability;Disease;DNA Methylation;Embryo;Enterobacteria phage P1 Cre recombinase;Epigenetic Process;Epilepsy;experience;experimental study;Failure;fetal;Funding;Gene Expression;Gene Transfer Techniques;Genes;Genetic;Genome;genome editing;Germ Cells;Germ Lines;germline stem cells;Goals;Health;Histology;histone modification;Homeobox;Homeobox Genes;Human;human model;In Vitro;in vivo;induced pluripotent stem cell;infancy;Injections;innovative neurotechnologies;Intellectual functioning disability;interest;Interneurons;Knock-in;Knowledge;Laboratories;life span;Link;lissencephaly;Magnetic Resonance Imaging;male;Marketing;Mediating;Methodology;Methods;migration;Modeling;Modification;Mus;mutant;Mutation;Nervous System Disorder;neural;Neuroanatomy;Neurobiology;Neurodegenerative Disorders;neurogenetics;Neurologic;neuron development;Neurons;neuropsychiatric disorder;neuropsychiatry;Newborn Infant;non-invasive imaging;nonhuman primate;Normalcy;novel;novel strategies;novel therapeutics;offspring;Operative Surgical Procedures;Organoids;Parents;Pathway interactions;Pharmaceutical Preparations;Pluripotent Stem Cells;polyalanine;Population;postnatal;Pregnancy;Primates;Production;Protocols documentation;reconstitution;Reporter;Research;Research Personnel;Rodent;Rodent Model;Role;single-cell RNA sequencing;skills;Source;sperm cell;Spermatocytes;Spermatogenesis;Study models;success;System;Testis;Therapeutic;therapeutically effective;therapy design/development;Tissues;tool;transcriptome sequencing;Transgenes;Transgenic Organisms;Translating;Translations;transmission process;Transplantation;United States National Institutes of Health;Validation;whole genome;Xenograft procedure

PROJECT_TITLE: Role of ARX mutations in marmoset brain organoids


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: This study is responsive to the identified need for more information on the health and corresponding healthcare needs of women veterans, as well as recognized gaps in the understanding of the gender-specific impact of military service on female and male veterans’ long-term health. Given that trauma exposure can have negative and lasting effects on health, traumatic stress and mental health sequelae (i.e., PTSD, depression, anxiety, and substance abuse) are a public health concern that is of particular relevance to VA clinical services. To date, risk models linking military service with health outcomes have been understudied in older populations, and especially in older women. Combining data from two important VA cooperative studies—the Health of Vietnam Era Women’s Study and the Veteran Health Study—will provide the foundation for key insights into gender differences in the long-term health effects of military service, including risk for cardiovascular and other chronic disease morbidity, as well as mortality due to these and other causes, including suicide.

PI_NAMEs: SMITH, BRIAN N (contact)

PROJECT_TERMS: Affect;Age;Aging;Anxiety;Area;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cessation of life;Characteristics;Chronic;Chronic Disease;Clinical;clinical care;Clinical Services;cohort;combat trauma;comorbidity;cooperative study;Data;Data Analyses;demographics;Disease;disease model;epidemiology study;Equation;Ethnic Origin;experience;Exposure to;Feeling suicidal;Female;Foundations;Funding;Gender;gender difference;Generalized Anxiety Disorder;Health;Health behavior;health difference;Health Priorities;Healthcare;healthcare burden;human old age (65+);indexing;insight;late life;Link;Literature;Location;long-term sequelae;Major Depressive Disorder;male;Malignant Neoplasms;Measures;Mediating;men;Mental Depression;Mental disorders;Mental Health;Methods;Military Personnel;military service;military veteran;Modeling;Morbidity - disease rate;mortality;mortality risk;Occupations;older adult;Older Population;older women;Outcome;Participant;Pathway interactions;Pattern;Play;poor health outcome;Post-Traumatic Stress Disorders;Prevalence;Prevention;Preventive care;Provider;Psychiatric Diagnosis;Psychosocial Factor;Public Health;Race;Records;Research;Research Design;Risk;Risk Behaviors;Risk Factors;Role;Sampling;Services;sexual trauma;Social support;Stress;Substance abuse problem;Substance Use Disorder;Suicide;Surveys;Telephone Interviews;Testing;Trauma;trauma exposure;traumatic stress;Twin Multiple Birth;Veterans;Vietnam;Vital Status;War;Woman;women versus men;Women's Health;Women's study

PROJECT_TITLE: Long-Term Health Impact of Vietnam Era Service: Examining Gender Differences in Risk of Mortality and Chronic Disease


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PI_NAMEs: ROBERTS, CHARLES  (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TITLE: Cancer Center Support Grant (CCSG)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Aging;Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative Inherited mutations in the gene DDX41 are the most common cause of genetic predisposition to Myelodysplastic Syndromes (MDS), a blood disease where the bone marrow fails to produce blood cells of sufficient quality and quantity. The goal of this proposal is to engineer a model of MDS in mice that accurately follows the natural genetic progression of the disease, beginning with inherited mutation of DDX41. These mouse models can then be used to elucidate the mechanisms by which mutations in DDX41 promote MDS onset.

PI_NAMEs: CHLON, TIMOTHY MICHAEL (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Accounting;Adult;Age;age acceleration;Age Months;aged;Aging;Alleles;Amino Acid Substitution;Amino Acids;Apoptosis;Biological Assay;Blood;Blood Cell Count;Blood Cells;bone aging;bone cell;Bone Marrow;Bone Marrow Cells;Bone Marrow Diseases;Bone Marrow Transplantation;Cell Cycle Arrest;Cells;Childhood;Clonal Expansion;Clonal Hematopoietic Stem Cell;Clonality;cohort;conditional knockout;conditional mutant;Cytogenetics;Defect;Development;Disease;disease model;Disease Progression;Dysmyelopoietic Syndromes;Elderly;Engineering;Engraftment;Erythrocytes;experimental study;Flow Cytometry;Gene Frequency;Genes;Genetic;Genetic Models;Genetic Predisposition to Disease;genetic variant;Germ Lines;Germ-Line Mutation;Goals;Health;Helicase Gene;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell subsets;Hematopoietic stem cells;Hemorrhage;Heterozygote;Histology;in vivo;Inherited;Knock-in;Knock-out;Length;Loss of Heterozygosity;LoxP-flanked allele;male;Marrow;Minor;Missense Mutation;Modeling;Molecular;mouse model;Mus;mutant;Mutate;Mutation;normal aging;novel strategies;old mice;Other Genetics;Pathogenesis;Patients;Penetrance;peripheral blood;Phenocopy;Phenotype;Population;Predisposition;prevent;Prevention strategy;Proliferating;protein function;Protein Truncation;Proteins;rational design;Risk;RNA Helicase;Role;sex;Site;Spleen;Tamoxifen;Testing;Titrations;Translations

PROJECT_TITLE: Advanced Mouse Models of DDX41-mutated Myelodysplastic Syndromes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE  TDP-43 proteinopathy and hippocampal sclerosis are established features of Alzheimer's Disease, but their complex interactions are not well understood. This proposal aims to leverage spatial sequencing technology to delve into the regional, cellular, and molecular dimensions of the interplay between new TDP-43 species and hippocampal sclerosis in the context of Alzheimer's Disease. Our study will facilitate the translation of recent advances in spatial transcriptomic studies to practical applications for Alzheimer's Disease.

PI_NAMEs: MAO, QINWEN  (contact);XIE, HEHUANG

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease brain;Amyloid beta-Protein;Antibodies;base;Binding;Biological Assay;Biological Markers;Brain;Cells;Communities;Complex;Comprehension;Cytoplasm;Data;data analysis pipeline;Dementia;density;Diagnosis;Dimensions;Disease;drug discovery;Exclusion;Exhibits;Foundations;Frontotemporal Lobar Degenerations;Funding;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;Genetic;Genomics;Gifts;Goals;hippocampal sclerosis;Hippocampus;immunoreactivity;in situ sequencing;Inclusion Bodies;Knowledge;Life;Light;limbic-predominant age-related TDP-43 encephalopathy;Link;meetings;Molecular;molecular marker;Monoclonal Antibodies;National Institute on Aging;Nature;Nerve Degeneration;Neurofibrillary Tangles;neuron apoptosis;neuron development;neuron loss;neuropathology;novel;Nuclear;Nuclear RNA;Pathologic;Pathology;Pathway Analysis;Patients;Pattern;Phosphorylation;Physical condensation;Play;practical application;Process;Property;protein TDP-43;public database;Regulation;Research;Resolution;Resources;response;RNA;RNA metabolism;Role;Sampling;synaptic function;tau Proteins;Techniques;Technology;Testing;Toxic effect;Transcript;transcriptomics;Translations;Universities;Utah;Virginia;Visualization

PROJECT_TITLE: Spatial Transcriptomics for Investigating the Interaction between TDP-43 Proteinopathy and Hippocampal Sclerosis in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Orphan Drug;Prostate Cancer;Rare Diseases;Urologic Diseases

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE  The overall objective of this study is to develop a well-defined 3D bioprinted in vitro model that mimics the molecular, cellular, and metabolic interplay occurring in the bone-tumor microenvironment of metastatic prostate cancer and confirm that it is responsive to novel targeted and non-targeted diagnostic and therapeutic modalities. The rationale for undertaking the proposed research is that development of a reproducible predictive PC tumor- bone-vasculature model will accelerate therapeutic development for PC and minimize clinical failures.

PI_NAMEs: BERKMAN, CLIFFORD ;CAROMILE, LESLIE ANN (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Animals;Antibody-drug conjugates;Antigen Targeting;Biochemical;bioink;bioprinting;Biopsy;Blood Vessels;bone;Bone neoplasms;cancer type;Castration;Cell Communication;Cell model;Cell Survival;cell type;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Colorectal Cancer;Combined Modality Therapy;cytotoxic;Deposition;Development;Diagnostic;Disease;dosage;Drops;drug action;Drug resistance;Effectiveness;effectiveness evaluation;Endosomes;Endothelial Cells;Endothelium;Ensure;Environment;Epithelial Cells;Epithelium;Event;Failure;flexibility;FOLH1 gene;frontier;Generations;Genetic Transcription;Goals;Growth Factor;Human;In Vitro;in vitro Model;in vivo;innovation;LNCaP;Lysosomes;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;malignant stomach neoplasm;Mechanics;Metabolic;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Minerals;Modality;Modeling;Molecular;mortality;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Oncogenic;Osteoblasts;Outcome;Pathologic Neovascularization;Pathway interactions;Patients;Performance;Permeability;personalized medicine;Pharmaceutical Preparations;pre-clinical;Pre-Clinical Model;Preventive;prostate cancer cell;prostate cancer metastasis;prostate cancer model;Radiation therapy;rational design;Renal Cell Carcinoma;Reproducibility;Research;Resistance;screening;small molecule;success;Surface;System;targeted agent;targeted treatment;Technology;Therapeutic;Therapeutic Agents;therapeutic development;therapeutic effectiveness;three-dimensional modeling;tumor;tumor growth;tumor microenvironment;Tumor Oxygenation;Tumor-associated macrophages;Vascular Endothelial Cell

PROJECT_TITLE: Frontiers in Bone Metastatic Models for Prostate Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (M3)]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: MADISON

ORG_NAME: SOCIETY FOR RESEARCH ON NICOTINE/TOBACCO

ORG_STATE: WI

PHR: PROJECT NARRATIVE The SRNT 2024 Annual Meeting is the optimal venue for the presentation of novel findings from tobacco regulatory science research projects and networking across scientists in this emerging field. The aims of this conference grant are to: 1) ensure that tobacco regulatory science content is presented in ways that are maximally informative to FDA and to researchers in the field; and 2) to highlight the work of trainees and early career investigators in tobacco regulatory science via special oral sessions, professional development forums, travel awards, and other recognition.

PI_NAMEs: BLANK, MELISSA D;KONG, GRACE ;SMILEY, SABRINA LYNN;TOLL, BENJAMIN ANDREW (contact)

PROGRAM_OFFICER_NAME: STATON, JILL

PROJECT_TITLE: Society for Research on Nicotine and Tobacco 2024 Annual Meeting

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CTP-J (02)]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Precision Medicine;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PI_NAMEs: BASFORD, MELISSA ;GLAZER, DAVID ;HARRIS, PAUL A. (contact);PHILIPPAKIS, ANTHONY ;RODEN, DAN M

PROGRAM_OFFICER_NAME: AZUINE, ROMULADUS EMEKA

PROJECT_TERMS: All of Us Research Program;Data;data infrastructure;Disease;Goals;Health;prevent;Research;Research Personnel;Vision

PROJECT_TITLE: All of Us Research Program Data and Research Center


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_DEPT: OPHTHALMOLOGY

PHR: NARRATIVE Normal brain function depends on the orderly development of circuits in the cerebral cortex and on their intact function. Knowledge of the normal circuitry provides a foundation for understanding the causes of impaired brain function and developing corrective measures. Our studies of the normal circuitry between early visual cortical areas will provide greater insight into the causes and effects of central vision defects when these circuits are damaged by stroke or other neurological or developmental cause. In particular, our studies of feedback circuits between different visual cortical areas will help our understanding of how these pathways mediate the influence of stimulus context on neuronal responsivity, spatial integration, and changes in visual sensitivity associated with top-down attention. Moreover, understanding how these circuits operate in normal vision will provide a foundation for understanding the consequences of their dysfunction in neurological and psychiatric disorders, such as autism, schizophrenia and attention deficits disorders, which have been directly linked to abnormalities in inter-areal connectivity [e.g. Belmonte et al. J. Neurosci. (2004) 24:9228-9231; Lynall et al. J. Neurosci. (2010) 30:9477-9487].

PI_NAMEs: ANGELUCCI, ALESSANDRA  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Administrative Supplement;Anatomy;Animals;Area;Attention;Attention Deficit Disorder;autism spectrum disorder;Award;Brain;brain dysfunction;Cerebral cortex;cost;Country;Defect;Development;Feedback;Foundations;Functional disorder;Funding;Goals;insight;Knowledge;Link;Macaca;Macaca fascicularis;Measures;Mediating;Mental disorders;Monkeys;Nervous System Disorder;Neurologic;Neurons;Parents;Pathway interactions;Price;Request for Applications;response;Schizophrenia;Shipping;spatial integration;Stimulus;Stroke;Time;Vision;Visual;Visual Cortex

PROJECT_TITLE: Anatomical and functional organization of inter-areal feedback circuits in the visual cortex, and their impact on neuronal responses


NIH_SPENDING_CATS: Cancer;Radiation Oncology

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Our current clinical approach to re-irradiation is not based on data, as guidelines vary widely and are not rooted in observed toxicities. This proposal aims at developing a novel re-irradiation framework integrating the patient’s response to the first treatment and the time the organ had to recover. This proposal will advance knowledge how to incorporate the patient’s individual response to the first radiation treatment, and the time that has passed since, into the planning of re-irradiation, which is crucial to control for the variability among patients to enable correct interpretation of toxicity data.

PI_NAMEs: GRASSBERGER, CLEMENS  (contact)

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Address;Agreement;Clinical;Clinical Treatment;clinically relevant;Colloids;Data;Databases;discount;discounting;Dose;Evolution;experience;follow-up;Foundations;Guidelines;Heterogeneity;Image;imaging biomarker;individual patient;individual response;innovation;insight;Institution;Intuition;irradiation;Knowledge;Liver;liver injury;Lung;lung injury;model generalizability;Modeling;Normal tissue morphology;novel;novel strategies;Organ;Outcome;patient response;patient subsets;Patients;Population;Publishing;Radiation;Radiation Oncology;radiation recovery;radiation response;Radiation therapy;Radiation Tolerance;radiation-induced injury;Recommendation;Recovery;Reporting;response;single photon emission computed tomography;Site;success;Sulfur;Sum;Time;Time Factors;tissue injury;Tissues;Toxic effect

PROJECT_TITLE: A generalizable model of normal tissue recovery to enable personalized re-irradiation

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (M2)]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Health Services;Pediatric;Prevention;Primary Health Care;Rare Diseases

ORG_CITY: Rockville

ORG_NAME: PEDIAMETRIX INC.

ORG_STATE: MD

PHR: NARRATIVE  Delayed identification of infant head malformation is causing unnecessary medical complications and societal costs, partly because of the absence of tools available to pediatric offices. For this Fast-track SBIR proposal, PediaMetrix Inc. has joined forces with clinical institutions to develop and evaluate a 3D mobile scanning tool that provides cranial volume and malformation measurements. Our tool, called SoftSpotTM, will improve the early detection and management of infant cranial malformations at the point-of-care and avoid delayed, costly and intensive treatments.

PI_NAMEs: AALAMIFAR, FERESHTEH  (contact);SEIFABADI, REZA

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: 3-Dimensional;Address;Adoption;Affect;Affinity;Algorithms;Area;Attention;base;Businesses;Cellular Phone;Cephalic;Child;Childhood;Clinic;Clinical;Complex;cost;Craniosynostosis;cranium;Data;Data Analyses;Data Collection;Dedications;design;Development;Devices;Diagnosis;digital;digital health;digital tool;Early Diagnosis;Early treatment;Economics;effective therapy;Ensure;Epidemic;Feedback;Generations;Geography;Goals;Grant;Growth;handheld mobile device;Head;Health;Health Care Costs;health management;Health Personnel;Image;improved;infancy;Infant;insight;Institution;Interview;Lead;Learning;Left;Location;Machine Learning;malformation;Maps;Market Research;Marketing;Measurable;Measurement;medical complication;metropolitan;Mission;Monitor;Morbidity - disease rate;Motion;Newborn Infant;parent grant;Parents;Patient risk;Pediatric Hospitals;pediatrician;Performance;plagiocephaly;point of care;Population;Positioning Attribute;Preparation;Prevalence;prevent;Private Practice;programs;quantitative imaging;Recommendation;Reporting;Research Project Grants;Running;Sales;Sample Size;Scanning;screening;Screening procedure;Secure;Shapes;Small Business Innovation Research Grant;social anxiety;societal costs;Structure;success;support tools;Surveys;Technology;Test Result;Time;timeline;tool;Validation;webinar;Well Child Visits

PROJECT_TITLE: Mobile Three-Dimensional Screening for Cranial Malformations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(10)-B]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative (Parent Grant) Protein allostery is a fundamental phenomenon in which ligand binding at one site affects substrate activity or ligand binding at a second, distal site of the protein. Allostery is a primary mode of regulation for enzymes and other proteins that drive signal transduction and metabolism, and it is now being used in some drug development efforts, even though the mechanisms of allostery are not well understood. The work in this project will characterize dynamics and allosteric communication pathways for the homodimeric enzymes chorismate mutase and thymidylate synthase, and for engineered optogenetic conformational switch proteins.

PI_NAMEs: LEE, ANDREW L (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Affect;Allosteric Regulation;Antineoplastic Agents;Area;Attention;base;Behavior;Binding Sites;Biochemistry;Biology;biophysical analysis;biophysical techniques;Calorimetry;Catalysis;chemical conjugate;Chemistry;Chorismate Mutase;Communication;dimer;Distal;drug development;drug discovery;Engineering;Enzymes;Escherichia coli;Exhibits;falls;flexibility;Fluorouracil;Foundations;Goals;Guanosine Triphosphate Phosphohydrolases;Human;improved;interest;Investigation;Label;Laboratories;Ligand Binding;Ligands;Metabolism;Molecular Conformation;molecular dynamics;Movement;Nature;NMR Spectroscopy;optogenetics;parent grant;Pathway interactions;Property;Protein Engineering;protein function;Proteins;Protomer;Regulation;Relaxation;Role;Signal Transduction;Signaling Protein;Site;small molecule;Structure;System;Technology;Thymidylate Synthase;Work;X-Ray Crystallography;Yeasts

PROJECT_TITLE: Mechanisms and dynamics of allosteric function in proteins

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Immunotherapy;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Transplantation;Women's Health Research

PHR: Narrative. Pregnancy stimulates a variety of changes in women that promote optimal health for mother and child, and minimizing disorders like prematurity, preeclampsia and stillbirth. This application investigates retained changes in mothers after pregnancy that further reduce susceptibility to these disorders in subsequent pregnancies.

PI_NAMEs: WAY, SING SING  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Acceleration;Address;Adopted;Adoptive Transfer;Alloantigen;Allogenic;Allografting;Antigens;Binding;Birth;CD4 Positive T Lymphocytes;Cell Differentiation process;Cells;Cessation of life;Child;Complication;CTLA4 gene;design;Disease;embryo/fetus antigen;Epidemiology;epidemiology study;experimental study;father role;fetal;FOXP3 gene;Fracture;Future;gain of function;Genetic Transcription;Goals;Haplotypes;health of the mother;healthy pregnancy;Human;Immune;Immunologics;improved;in utero;Inbred Strain;Individual;Infant Mortality;Inflammatory;Interleukin-10;Knowledge;Maternal-Fetal Exchange;member;Memory;Modeling;Mothers;Mus;Nulliparity;Organ Transplantation;parity;Phenotype;Physiological;post pregnancy;Postpartum Period;Pre-Eclampsia;Predisposition;Pregnancy;Pregnancy Complications;Pregnancy Outcome;premature;programmed cell death protein 1;promote resilience;Publishing;reconstitution;Regulatory T-Lymphocyte;Reporter;resilience;response;Risk;Science;selective expression;skin allograft;Solid;Specificity;Splenocyte;stillbirth;T memory cell;Time;Tissues;tool;transplant model;Transplantation;Woman;Work

PROJECT_TITLE: Parity, paternity and pregnancy outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 HSC-X (M1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Social Determinants of Health

ORG_STATE: CA

PHR: Project Narrative Alzheimer’s disease and related disorders (ADRD) research represents an area of major national investment. But ADRD research faces delays and risks to internal and external validity resulting from consistent challenges to efficient and generalizable accrual. Recruitment registries are tools to address these challenges by establishing large repositories of individuals who are potentially eligible and willing to participate in research, expediting discovery. This proposal will provide researchers with critical evidence to instruct methods to diversify registries by including people from the most disadvantaged neighborhoods and addressing sample bias in these unique recruitment interventions.

PI_NAMEs: GILLEN, DANIEL L;GRILL, JOSHUA  (contact);KIND, AMY J.

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: Acceleration;Address;Alzheimer's disease related dementia;Area;Bolus Infusion;Clinical Research;cohort;Consent;Data;design;disorder risk;Effectiveness;Eligibility Determination;Enrollment;Face;Individual;Intervention;Investments;Methodology;Methods;Modernization;neighborhood disadvantage;Neighborhoods;Parents;Participant;participant retention;Persons;Population;recruit;Registries;repository;Research;Research Personnel;Research Project Grants;Resources;Risk;Sampling;Sampling Biases;social health determinants;tool;Validity of Results

PROJECT_TITLE: Recruiting and retaining participants from disadvantaged neighborhoods in registries

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(90)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Balancing between tumor control and preserving post-treatment speech outcomes is of primary importance in surgical management of patients with early-stage laryngeal cancer. Transoral laser microsurgery has become the primary surgical approach to endolaryngeal tumors, although no reliable approaches are approved to aid the surgeon's intraoperative visual assessment of tumor borders. This study will demonstrate clinical feasibility for a novel, combinatorial optical imaging approach to aid intraoperative identification of laryngeal cancer borders for surgical treatment while preserving essential normal tissue.

PI_NAMEs: PANUGANTI, BHARAT ;WARRAM, JASON MORGAN (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Address;Aftercare;arm;Biopsy;cancer diagnosis;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;combinatorial;Contrast Media;Decision Making;Deglutition;design;diagnostic criteria;Disease;Dysplasia;Early treatment;EGFR Protein Overexpression;Epidermal Growth Factor Receptor;Excision;feasibility trial;Fluorescein;Fluorescence;fluorescence imaging;fluorescence-guided surgery;Foundations;Goals;Head and neck structure;Histopathology;Image;Image-Guided Surgery;imaging approach;Individual;intraoperative optical imaging;Laryngeal neoplasm;Laryngeal Squamous Cell Carcinoma;Laryngectomy;Larynx;Lasers;Malignant - descriptor;Malignant neoplasm of larynx;Malignant Neoplasms;microendoscopy;Microsurgery;Nature;Near-infrared optical imaging;Normal tissue morphology;novel;open label;Operative Surgical Procedures;optical imaging;Optics;Oral;Organ;Outcome;Outcome Study;overexpression;panitumumab;Pathologic;Pathology;Patients;phase II trial;preservation;Procedures;prospective;Randomized;Recurrence;Recurrent disease;Signal Transduction;soft tissue;Specimen;Speech;Squamous cell carcinoma;standard of care;Surgeon;Surgical Management;Surgical margins;Testing;Time;Tissues;treatment planning;tumor;Visual;Voice

PROJECT_TITLE: Combination optical imaging to guide transoral laser microsurgery in larynx cancer


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Food security – having consistent access to healthy foods – is important for prevention and management of diet-sensitive chronic diseases such as diabetes. This is especially critical for communities of color who are disproportionately impacted both by food insecurity and diet-sensitive chronic diseases. Policies such as the recent CalAIM Medicaid waiver, which is a recently implemented policy that allows healthcare organizations to be reimbursed for providing healthy food, address this double burden. This study will assess the impact of the CalAIM policy change on food insecurity, diet quality, obesity, and indicators of cardiometabolic risk among diverse patients with obesity.

PI_NAMEs: ROSAS, LISA GOLDMAN (contact);TESTER, JUNE M

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Address;Adult;Asian;Behavioral;beneficiary;Biological Assay;Biological Markers;Black race;blood lipid;Body mass index;California;cardiometabolic risk;cardiometabolism;Cholesterol;Chronic;Chronic Disease;Clinical;Collection;Color;Communities;community partnership;comparison control;County;Data;Data Collection;Diabetes Mellitus;Diagnosis;Diet;Dietary intake;Dietary Intervention;Disease;Disparity;Effectiveness;effectiveness evaluation;Electronic Health Record;Equity;Ethnic Origin;experience;follow-up;Food;Food Access;food challenge;food insecurity;food security;glycemic control;Glycosylated hemoglobin A;Health;Health behavior;Health behavior and outcomes;Health Benefit;health care service organization;health equity promotion;Health Food;Healthcare;Healthcare Systems;Healthy Eating;Heart Diseases;High Density Lipoprotein Cholesterol;Home;Hour;Household;Hunger;improved;Income;indexing;Individual;Inequity;Infrastructure;innovation;Laboratories;Latinx;Life;Lipids;Low income;Low Income Population;Measures;Medicaid;Medical;Medicine;Modeling;Morbidity - disease rate;mortality;Native Americans;Natural experiment;Not Hispanic or Latino;nutrition;nutrition education;obese patients;Obesity;Pacific Islander;Participant;patient population;Patients;Pharmacy facility;point of care;point of care testing;Policies;Policy Maker;Population Heterogeneity;Positioning Attribute;Prevention;primary care patient;prospective;Provider;Quasi-experiment;Race;recruit;Research Personnel;Resources;Sampling;Security;social group;Surveys;symposium;Telephone;Time;United States;waiver;Work

PROJECT_TITLE: Effectiveness of Recipe4Health on Obesity and Cardiometabolic Health: A natural experiment

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-1 (M1)]


NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OAKLAND UNIVERSITY

ORG_STATE: MI

PHR: Narrative Diabetic retinopathy (DR) is a common complication of diabetes mellitus that causes significant damage to the blood vessels and nerve cells of the retina. While our previous studies established the role of 12/15-lipoxygenase (12/15-LO) enzyme in inducing damage to retinal blood vessels in diabetes, there is still a gap in understanding of the underlying mechanisms. This project will investigate the role of G-coupled protein receptors (GPR31 and GPR39), suggested receptors for 12/15-LO metabolites in retinal vascular damage that occurs in DR.

PI_NAMEs: AL-SHABRAWEY, MOHAMED AL-SAYED (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: 12-HETE;3-Dimensional;adenoviral mediated;Affect;Affinity;Age;Arachidonate 15-Lipoxygenase;Binding;Biological Assay;Blindness;Blood Preservation;Blood Vessels;Blood-Retinal Barrier;Calorimetry;cell motility;Cell Survival;Cells;Complex;Complications of Diabetes Mellitus;Computer software;cytokine;Data;design;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Retinopathy;Docking;Economic Burden;electric impedance;Endothelial Cells;Enzymes;Experimental Models;extracellular;Functional disorder;G-Protein-Coupled Receptors;gain of function;Genes;Glucose;Glutamates;Goals;GPR31 receptor;GPR39 gene;Human;Hydroxyeicosatetraenoic Acids;Hyperglycemia;improved;Inflammatory;Inflammatory Response;inhibitor;Interferometry;Kinetics;Lipoxygenase Inhibitors;loss of function;Mediating;Membrane;migration;Molecular;Muller's cell;Mus;Neurons;neurovascular;new therapeutic target;Osmosis;overexpression;Oxidative Stress;Oxygen;Pathogenesis;Pathway interactions;pharmacologic;Play;Population;preservation;protein structure;Proteins;Rattus;receptor;Recombinants;Retina;retina blood vessel structure;retinal damage;Retinal Diseases;Retinal Neovascularization;Role;Side;Signal Pathway;Signal Transduction;Small Interfering RNA;socioeconomics;Source;Specificity;Substrate Specificity;Testing;therapeutic target;Thermodynamics;Tight Junctions;Titrations;Tube;Up-Regulation;Vascular Diseases;Vascular Endothelial Growth Factors

PROJECT_TITLE: Toward Targeting GPR31 and GPR39 Signaling in Diabetic Retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: DURHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: DUKE UNIVERSITY

PHR: Opioids are often prescribed to manage neuropathic pain, but their addictive properties have led to the opioid crisis, posing a serious global challenge. This has created an urgent need for the development of non-addictive pain management alternatives. Our proposed research is to validate and explore human equilibrative nucleoside transporters (ENTs) as potential targets for pain relief. Our research proposal, if successful, could provide a platform to improve the lives of patients suffering from neuropathic pain.

PI_NAMEs: HONG, JIYONG ;JI, RU-RONG ;LEE, SEOK-YONG  (contact)

PROGRAM_OFFICER_NAME: BACHMAN, JULIA LYNN

PROJECT_TERMS: abuse liability;addiction;addiction liability;Address;Adenosine;Adenosine A1 Receptor;adenosine transporter;Afferent Neurons;Affinity;Agonist;Analgesics;Animal Model;Animals;assay development;Binding;Biological Assay;Biology;Cells;Clinical;Complex;conditioned place preference;Data;design;Development;Diabetic Neuropathies;drug discovery;Drug Kinetics;efficacy study;Electrophysiology (science);Equilibrative Nucleoside Transporter 1;Exhibits;extracellular;Foundations;Funding;Future;Goals;high throughput screening;Human;improved;In Vitro;in vitro Assay;in vivo;inhibitor;Measures;Methods;Modeling;Molecular Target;monoamine;multidisciplinary;Neuropathy;neuroregulation;Neurotransmitters;non-opioid analgesic;novel;novel strategies;Nucleoside Transporter;Oocytes;Opioid;opioid epidemic;Outcome Measure;Overdose;Pain;Pain management;pain model;pain receptor;pain relief;Pain Research;painful neuropathy;Parents;Pathway interactions;Patients;Pharmaceutical Chemistry;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phase;Property;Radioactive;rational design;receptor;Receptor Activation;Receptor Inhibition;recruit;Research;Research Proposals;reuptake;Risk;Role;Scientist;Scintillation Counter;screening;Selective Serotonin Reuptake Inhibitor;side effect;Slice;Spinal Cord;Spinal Ganglia;structural biology;Structure;success;Synaptic Transmission;System;Testing;Therapeutic;therapeutic target;Universities;uptake;Validation;Work;Yeasts

PROJECT_TITLE: Developing equilibrative nucleoside transporter inhibitors as non-opioid pain therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-S (20)]