NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Hypertension;Pediatric;Prevention;Social Determinants of Health;Stroke

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Public Health Relevance Although there is a substantial burden of hypertension and stroke among older adults in Nigeria, there are significant gaps in implementing evidence-based blood pressure/stroke prevention interventions. The study will engage young people and their older adult caregivers using music-inspired strategies to increase uptake of essential BP/stroke prevention services. Given the ubiquitous and high relevance nature of music, the findings from this study will be relevant to other resource-constrained settings experiencing a high burden of hypertension, stroke, and traditionally underrepresented in implementation research.

PI_NAMEs: EZECHI, OLIVER CHUKWUJEKWU;IWELUNMOR, JULIET  (contact);TUCKER, JOSEPH DAVID;WILLIAMS, OLAJIDE

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: Acceleration;Address;Affect;Age;American;apprenticeship;Area;Behavior;Behavioral;Blood Pressure;blood pressure reduction;cardiovascular health;Caregivers;Characteristics;Climate;Communities;community based participatory research;Community Health Aides;Consolidated Framework for Implementation Research;crowdsourcing;Data;Development;Effectiveness;effectiveness/implementation trial;Elements;Equity;Evaluation;evidence base;Evidence based intervention;experience;experimental study;Foundations;Generations;Geographic Locations;Geography;Goals;Government;grandparent;Health;Health Professional;Health Services;HIV;Hybrids;Hypertension;hypertension control;implementation outcomes;implementation process;implementation research;implementation strategy;implementation trial;Individual;innovation;Interdisciplinary Study;Intervention;Knowledge;Leadership;Learning;Life;Life Style;Link;literacy;Maintenance;Medical Research;Mentorship;Methods;Modeling;modifiable risk;Music;Nature;Nigeria;Nigerian;older adult;Outcome;Parents;Perception;Persons;pragmatic trial;Prevention;prevention service;preventive intervention;Preventive measure;primary outcome;Proctor framework;Proliferating;Public Health;public health intervention;public health relevance;Randomized, Controlled Trials;Readiness;Recommendation;Recording of previous events;recruit;Reduce health disparities;Research;Resource-limited setting;Risk;Risk Factors;risk perception;Sampling;secondary outcome;self testing;skills;social;social health determinants;sound;Stroke;stroke intervention;Stroke prevention;stroke therapy;supportive environment;therapy design;tool;treatment as usual;United States National Institutes of Health;uptake;willingness;World Health Organization;Youth

PROJECT_TITLE: Innovative Tools to Expand Music-Inspired Strategies for Blood Pressure and Stroke Prevention (I-TEST BP/Stroke)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-G(50)R]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Patient Safety;Prevention;Radiation Oncology

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Clonal hematopoiesis (CH) mutations are acquired mutations in the blood present in the majority of older individuals that may contribute to worse oncologic outcomes in patients with solid malignancy. In this project we will use individual genetic and clinical data to determine whether CH mutations and cancer therapies interact to result in worse cancer treatment toxicity and outcomes and to investigate whether there are clinical markers to determine which individuals may be most at risk for these adverse outcomes. Completion of this project will provide key insight regarding the importance of CH mutations in patients with solid malignancy and guide future investigations regarding whether knowledge of CH mutations in patients with solid malignancy can improve cancer care.

PI_NAMEs: NEAD, KEVIN THOMAS (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Adverse event;adverse outcome;Award;biobank;Bioinformatics;Biological Markers;Blood;Blood specimen;Breast;cancer care;Cancer Center;cancer prevention;cancer therapy;cardiac magnetic resonance imaging;Cardiovascular Diseases;career;career development;Caring;Cells;Characteristics;chemoradiation;Chemotherapy and/or radiation;Chest;Chromosome abnormality;Clinical;clinical biomarkers;clinical candidate;Clinical Data;Clinical Markers;Clinical Research;cohort;Collection;complex data;Data;data registry;Data Set;Department chair;Development Plans;Disease;DNA Sequence Alteration;DNA sequencing;Education;Educational process of instructing;Electronic Health Record;Eligibility Determination;Environment;environmental mutagens;Epidemiology;Event;Evolution;Exercise stress test;exome sequencing;experience;Exposure to;Frequencies;Funding;Future;Genetic;Genomics;Genotype;Goals;Health;Hematopoiesis;improved;Individual;Inherited;insight;Interdisciplinary Study;International;Investigation;Knowledge;Link;Lung Diseases;Malignant Neoplasms;Mentors;Mentorship;Methodology;Methods;Modeling;Mutate;Mutation;Mutation Analysis;mutational status;neoplasm registry;Normal tissue morphology;novel;Older Population;Oncology;Outcome;Patient Care;Patients;Physicians;Population;Positioning Attribute;Prevention;Process;professor;programs;Proliferating;prospective;Prospective cohort;Publishing;Radiation Oncology;Radiation therapy;Recurrence;Replication Error;Research;research and development;Research Design;Research Personnel;Resources;Risk;Sampling;Scientist;skill acquisition;skills;Solid;Somatic Mutation;Spirometry;therapy adverse effect;Time;Tissues;Toxic effect;Training;Treatment outcome;Treatment-related toxicity;whole genome

PROJECT_TITLE: Impact of clonal hematopoiesis mutations on toxicity and outcomes following oncologic therapy

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Patient Safety;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases;Rehabilitation

ORG_CITY: BIRMINGHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Childhood cancer survivors are at an inordinately high life-long risk of anthracycline-related cardiac dysfunction (CD) and radiation-related subsequent neoplasms (SNs). Although there is a dose-response relation between these therapeutic agents and CD or SN, there is significant inter-patient variability in risk, suggesting the moderating role of genetic predisposition. This Outstanding Investigator Award application breaks new ground by harnessing and merging novel concepts from the field of molecular biology, pharmacogenomics and cancer survivorship to identify childhood cancer patients by their personal risk of CD or SN, such that personalized management approaches can be instituted to mitigate this burden of morbidity.

PI_NAMEs: BHATIA, SMITA  (contact)

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: Acceleration;Age;Alabama;American;American Society of Clinical Oncology;Anthracycline;anti-cancer research;Award;Cancer Patient;Cancer Survivorship;Charge;childhood cancer survivor;Chronic;clinical investigation;Clinical Trials Cooperative Group;cohort;Collaborations;Coupled;Development;Dose;Epidemiology;experience;Funding;Future;Genetic;Genetic Predisposition to Disease;genetic signature;Goals;Health;high risk;improved;Incidence;indexing;Infrastructure;inter-individual variation;interpatient variability;Intervention;leukemia/lymphoma;Life;Malignant Childhood Neoplasm;Malignant Neoplasms;member;Modeling;Molecular;Molecular Biology;Morbidity - disease rate;Myocardial dysfunction;Neoplasms;Newly Diagnosed;novel;Oncology;Outcome;Outcomes Research;Pathogenesis;Patients;Pediatric Oncology;Pediatric Oncology Group;Peer Review;personalized management;Pharmacogenomics;Physicians;Population;Premature Mortality;Prevention;Publications;Qualifying;Radiation;Research;Research Personnel;response;Risk;risk prediction;risk prediction model;Role;Shapes;Societies;survivorship;Therapeutic;Therapeutic Agents;treatment risk;Universities

PROJECT_TITLE: Mitigating Long-term Treatment-related Morbidity in Childhood Cancer Survivors


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: Project Narrative How the exact same DNA sequence that is present in every cell gives rise to cellular diversity has been at the center of biological research for many decades. This process involves the orchestrated recruitment of hundreds of regulatory factors to precise DNA and RNA regions in the nucleus, yet, it remains unclear how these numerous regulatory components reliably assemble, interact with their targets, and quantitatively control gene expression. Here we will develop highly innovative methods to measure the combinatorial and 3-dimensional spatial assembly of hundreds of molecules, their dynamics across time, and their quantitative role in gene regulation.

PI_NAMEs: GUTTMAN, MITCHELL  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: 3-Dimensional;Bar Codes;Binding;Biochemical;Biological;Biological Process;biological research;Biology;biophysical model;Cell Nucleus;Cells;Chromosomes;combinatorial;Complex;Computer Models;Coupling;Data;Disease;DNA;DNA Sequence;Enhancers;Ensure;epigenetic silencing;Event;functional group;Gene Expression;Gene Expression Regulation;Gene Rearrangement;Gene Silencing;Genes;Genetic;Genetic Diseases;Genetic Transcription;genome-wide;Genomic DNA;Genomics;Goals;Heterochromatin;human disease;Individual;innovation;insight;Kinetics;Link;Liquid substance;Malignant Neoplasms;Maps;Measurement;Measures;Mediating;Membrane;Messenger RNA;Methods;Microscopy;Modeling;Molecular;molecular assembly/self assembly;molecular dynamics;Monitor;Movement;movie;Nerve Degeneration;Neurodegenerative Disorders;novel;novel strategies;Nuclear;Nuclear Structure;Phase;Play;Process;promoter;protein complex;Proteins;Recording of previous events;recruit;Reporting;Resolution;RNA;RNA Polymerase II;RNA Splicing;Role;single molecule;Structure;temporal measurement;Time;Tissues;tool;Toxic effect;Transcription Process

PROJECT_TITLE: How phase-separation in the nucleus organizes 3D spatial assembly and gene regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-A(51)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Advances in the technologies used to decipher genomic function in development and disease are giving rise to new computational and statistical challenges. Our team has extensive experience developing computational tools and statistical methodology in this area. We will leverage our expertise to develop solutions to some of the most urgent needs of the research community and disseminate these as open source software.

PI_NAMEs: IRIZARRY, RAFAEL ANGEL (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Address;Affect;Algorithms;Area;ATAC-seq;Automobile Driving;Bar Codes;Base Sequence;Binding;Bioconductor;Biological;cell type;Cells;ChIP-seq;Chromatin;Communities;Complex;Computer software;computerized tools;Data;Data Analytics;data integration;Data Set;Deoxyribonucleases;Development;Disease;Elements;experience;functional genomics;Gene Expression;Gene Expression Regulation;Genes;genomic data;Genomics;high throughput analysis;high throughput technology;improved;Individual;Intuition;Joints;Knowledge;large datasets;Maps;Measurement;Methodology;Methods;model building;Morphologic artifacts;Nature;new technology;next generation;next generation sequencing;open source;Outcome;Paper;Performance;Process;Proteins;Protocols documentation;Pythons;Regulatory Element;Research;Research Personnel;response;RNA;Signal Transduction;single cell ATAC-seq;single cell technology;single-cell RNA sequencing;Sorting;Source;Speed;Statistical Models;Technology;Tissues;tool;transcription factor;user-friendly;Variant;whole genome;Work

PROJECT_TITLE: Next Generation Computational Tools for Functional Genomics

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Prevention;Social Determinants of Health;Women's Health Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Even in the context of viral suppression, WLWH have higher rates of cognitive impairment (CI) and stronger associations with many of the underlying CI biopsychosocial risk factors as well as unique sex-specific risk factors. We aim to examining putative biological pathways involving immune activation and neurobiological pathways (i.e., depletion of neurotransmitters, increased neurotoxic metabolites, and neuronal damage) to identify the markers that can be tightly linked to the clinical course of CI phenotypes in WLWH. This project examines also the role of psychosocial factors in impairing cognitive functions by exacerbating immune activation and neurobiological pathways directly and indirectly through ART levels adherence among WLWH.

PI_NAMEs: NORCINI PALA, ANDREA ;WHEELER, PARIYA FAZELI (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Address;Adherence;Affect;Age;aged;Aging;antiretroviral therapy;Attention;Behavior Therapy;Behavioral;Biological;Biological Markers;biopsychosocial;Chronic;Chronic stress;Clinical;Cognitive;cognitive function;cost effective;Data;Development;Discrimination;Dopamine;Dopamine Uptake Inhibitors;Etiology;Evaluation;executive function;experience;Goals;Hair;high risk;HIV;Immune;immune activation;Immunologic Markers;immunoregulation;Immunotherapy;Impaired cognition;improved;Individual;Individual Differences;Inflammatory;Infrastructure;Interleukin-6;Intervention;Knowledge;Learning;Letters;Life;Light;Link;Longitudinal Studies;marginalization;Mediating;men;Mental Depression;Mental Health;Metabolism;multi-component intervention;nerve injury;neurobiological mechanism;Neurobiology;Neurocognitive Deficit;neurofilament;Neurons;Neuropsychology;neurotoxic;Neurotransmitters;Norepinephrine;Outcome;Pathway interactions;Persons;pharmacologic;Phenotype;Phenylalanine;Prevention;psychosocial;Psychosocial Factor;public health priorities;Quinolinic Acid;racial diversity;resilience;Risk;Risk Factors;Role;Serotonin;sex;Short-Term Memory;social stigma;Social support;Specimen;substance use;therapy adherence;Time;TNF gene;Treatment/Psychosocial Effects;Tryptophan;Viral;Woman;Women's Group;Women's Interagency HIV Study;Work

PROJECT_TITLE: Evaluation of Neurobiological Mechanisms Mediating the Effect of Immune Activation on Neurocognitive Impairment and the Role of Psychosocial Factors Among Women Living with HIV


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Estrogen;Hepatitis;Liver Cancer;Liver Disease;Nutrition;Rare Diseases;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE  Hepatocellular carcinoma (HCC) has a high mortality rate and its incidence exhibits significant sexual dimorphism, as males have a higher risk for developing HCC than females. This proposal will utilize a new model that we developed of diet-induced progression of NASH to HCC that recapitulates key changes observed in the human disease to examine previously unrecognized roles of sphingosine kinase 2, an enzyme that regulates the balance of bioactive sphingolipid metabolites, in sexual dimorphism of HCC. The proposed studies have strong mechanistic and translational significance.

PI_NAMEs: GREEN, CHRISTOPHER D (contact);SPIEGEL, SARAH

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Androgen Metabolism;Androgen Receptor;Androgens;Animal Model;Binding;c-myc Genes;Cancer Etiology;Carcinogens;Cell Cycle;Cell Nucleus;Cells;Ceramides;Cessation of life;Cholesterol Homeostasis;Clinical Trials;Data;Death Rate;Development;Diet;Disease;Enzymes;Equilibrium;ESR1 gene;Estrogens;Etiology;Exhibits;Fatty Acids;Female;Gene Expression;gene repression;Generations;Genes;Genetic Transcription;Hepatic;Hepatocarcinogenesis;Hepatocyte;High Fat Diet;high risk;Histologic;Histone Acetylation;Histone Deacetylase;Human;human disease;Incidence;Inflammation;inhibitor;intrahepatic;Isoenzymes;Knock-out;Knockout Mice;Link;Lipids;Liver;liver cell proliferation;Liver Mitochondria;male;Malignant neoplasm of liver;Mediating;men;Metabolic;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Nuclear;Obesity;Oncogenic;Organelles;Oxidative Stress;Pathway interactions;Patients;personalized medicine;Physiological;Play;Predisposition;premalignant;Primary carcinoma of the liver cells;Production;Prognosis;prohibitin;Proliferating;Publishing;Reactive Oxygen Species;Regulation;Reporting;Resistance;Respiration;respiratory;Risk;Rodent;Role;sex;Sex Differences;sexual dimorphism;sexual disparity;Signal Pathway;Signal Transduction;Signaling Protein;Sphingolipids;sphingosine 1-phosphate;sphingosine kinase;stem cells;Structure;sugar;Techniques;Testing;Testosterone;transcriptomics;treatment strategy;Triglycerides;tumor;tumor initiation;tumorigenesis;Water;Woman

PROJECT_TITLE: Sphingosine kinase 2 in sexual dimorphism of hepatocellular carcinoma

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Getting and keeping people with HIV (PWH) on HIV treatment and virally suppressed (i.e., can no longer transmit the virus) is critical to ending the HIV epidemic in the US, but many PWH still face numerous barriers accessing HIV care, especially if they experience complex needs like poverty or untreated mental health conditions. This study evaluates a set of low-barrier care strategies adapted for Ryan-White-funded HIV primary care clinics designed to make it easier for PWH with complex needs to get into care. Results from this study will facilitate the use of low-barrier care strategies in new settings to reach more PWH who are currently out of care.

PI_NAMEs: BENBOW, NANETTE DIOR;LI, DENNIS HENYEE (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Acute;Address;Adoption;Area;arm;budget impact;care coordination;care delivery;care providers;Caring;Case Management;Centers for Population Health;Chicago;Clinic;Complex;contextual factors;Continuity of Patient Care;cooking;cost;County;Data;data enclave;design;Diagnosis;Diffuse;Discrimination;disparity reduction;Effectiveness;Eligibility Determination;Epidemic;epidemic preparedness;evidence base;experience;Face;follow-up;Funding;Goals;Health Services Accessibility;HIV;Home;Homelessness;Illinois;implementation context;implementation cost;implementation evaluation;implementation fidelity;implementation outcomes;implementation protocol;implementation research;implementation science;implementation strategy;improved;Incentives;Individual;innovation;Insurance;interest;Lead;Learning;Location;Maps;Mental Health;Methods;Modeling;NIH Office of AIDS Research;Outcome;outreach;Persons;Phase;Population;Poverty;pragmatic trial;Preparation;Primary Care;primary care clinic;Process;Process Assessment;Protocols documentation;Public Health;Ramp;retention rate;Screening procedure;service delivery;service engagement;Services;Site;social factors;social stigma;structural determinants;Substance abuse problem;substance use;System;Time;time use;Training;treatment disparity;trial design;United States;Viral;viral transmission;Visit;Walking;Work

PROJECT_TITLE: Promoting Sustained Viral Suppression Through Implementation of an Adapted Evidence-Informed Low-Barrier Care Model in a System of HIV Primary Care Clinics


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Patient Safety;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative: Tibial shaft fractures are a common injury resulting in significant problems including inability to return to work and societal functions. The identification of how individuals load their limb over time and how physical therapy contributes to tibial loading is unknown. We propose to define how individuals increase load over time, how physical therapy loads the tibia, and how recovery is influenced by loading.

PI_NAMEs: NOEHREN, BRIAN  (contact);ZELIK, KARL E

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Affect;Algorithms;American;Back;Biofeedback;Biological Markers;bone;Caring;Clinic;Clinical;Data;Data Set;demographics;design;Dose;Early Intervention;empowerment;Ensure;Exercise;exercise program;exercise rehabilitation;experience;Fill-It;follow-up;Fracture;functional outcomes;Future;Goals;Guidelines;Health Care Costs;Home;Hospitals;improved;in vivo;Individual;Injury;innovation;Intervention;Journals;Knowledge;knowledgebase;Laws;Leisure Activities;Length of Stay;Life;light weight;limb injury;Limb structure;Link;Longitudinal Studies;Measurement;Measures;mechanotransduction;Modeling;Monitor;Muscle;Musculoskeletal Diseases;novel;Office Visits;Operative Surgical Procedures;Outcome;Pain;Pathway interactions;Patient-Focused Outcomes;Patients;Physical therapy;Postoperative Period;pressure;programs;Publishing;Reaction;Recovery;Recovery of Function;Rehabilitation therapy;remote monitoring;Reporting;Risk;sample fixation;sensor;Severities;Shoes;standard of care;System;Techniques;Testing;tibia;Tibial Fractures;Time;tool;Training;Walking;wearable data;wearable device;wearable monitor;wearable sensor technology;Work

PROJECT_TITLE: Leveraging Wearables to Transform Patient Recovery after Tibial Fracture Surgery

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;HIV/AIDS;Human Genome;Infectious Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Structurally dissecting APOBEC3s for HIV-1 restriction and beyond The human immune system protects us against pathogens but can cause problems when the system goes awry. Implicated in both innate and adaptive immunity, the AID/APOBEC family of enzymes are cytidine deaminases with differential roles of still limited understanding. A subset of APOBEC3s (A3s) were initially discovered to potently restrict HIV-1, including A3G, A3F and A3H. However, A3 activity can be a double-edged sword. If not properly regulated, DNA-editing A3s that also have access to the nucleus can deaminate self-genomes, potentially instigating cancer. In this proposal we are leveraging our complementary strengths through a multi-disciplinary approach combining structural biology, biophysics, enzymology, chemistry and virology, to characterize the molecular interactions and differential specificities of A3s to nucleic acids and HIV-1 Vif, which will provide epitopes that once characterized will be target sites for future therapeutic development.

PI_NAMEs: SCHIFFER, CELIA A. (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Active Sites;adaptive immunity;Address;Binding;Biological Assay;Biophysics;Catalytic Domain;Cell Nucleus;Chemicals;Chemistry;chemotherapy;Collaborations;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Cytidine Deaminase;Data;Deamination;Dependovirus;design;Dinucleoside Phosphates;DNA;DNA Viruses;Double Stranded DNA Virus;Drug Design;Engineering;Ensure;Enzymatic Biochemistry;Enzymes;Epitopes;experience;Family;Future;Genome;Genomics;Goals;Head and Neck Cancer;Hepatitis B Virus;HIV;HIV-1;Human;Human Papillomavirus;Immune system;inhibitor;interdisciplinary approach;intermolecular interaction;Knowledge;Laboratories;Letters;Libraries;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;molecular modeling;Mutation;Natural Immunity;Nuclear;Nucleic Acids;Oligonucleotides;overexpression;Pan Genus;particle;pathogen;Positioning Attribute;Reagent;Research;Retrotransposon;Retroviridae;RNA;Roentgen Rays;Role;Series;Single Stranded DNA Virus;Single-Stranded DNA;Site;Source;Specificity;structural biology;Structure;Substrate Specificity;Surface;System;Therapeutic;therapeutic development;Translating;tumor;ubiquitin-protein ligase;Variant;vif Gene Products;Viral;Viral Genome;Virion;virology;Virus;Virus Diseases

PROJECT_TITLE: Structurally dissecting APOBEC3's for HIV-1 restriction and beyond

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Genetics;Mental Health;Neurosciences;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SIOUX FALLS

ORG_NAME: SANFORD RESEARCH/USD

ORG_STATE: SD

PHR: Narrative Dysregulation of neural progenitor proliferation during cortical development can lead to neuropediatric diseases, yet the mechanisms regulating proliferation of these cells remain poorly understood. We will focus on the disease-related gene ZBTB7A, to understand how disruption of epigenetic mechanisms modulating gene expression in NPs can lead to disease. Therefore, these studies will provide new insights into the epigenetic mechanisms regulating the development of the cerebral cortex, and how disruption of these mechanisms can lead to neuropediatric diseases.

PI_NAMEs: PILAZ, LOUIS-JAN  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Affect;Architecture;autism spectrum disorder;Binding;Biological Assay;Birth;brain size;Cell Cycle;Cell Nucleus;Cell Proliferation;cell type;Cells;Cerebral cortex;Cleavage Under Targets and Release Using Nuclease;Co-Immunoprecipitations;Complex;conditional knockout;Core Protein;critical period;Data;Deacetylase;Defect;Development;Disease;Electroporation;Embryo;Embryonic Development;Enhancers;Epigenetic Process;Erythroid Cells;Etiology;experimental study;Gene Expression;Genes;Hematopoietic stem cells;histogenesis;Human;Hybrids;Image;in utero;in vivo;insight;Intellectual functioning disability;knock-down;Knockout Mice;Lead;Link;Luciferases;Macrocephaly;Measures;Missense Mutation;Modeling;Molecular;mouse model;Mus;Mutation;nerve stem cell;Neurodevelopmental Disorder;Neurons;neuroregulation;notch protein;novel;Nucleosomes;overexpression;Pathway interactions;Patients;Phenocopy;Phenotype;postnatal;premature;Production;Proliferating;promoter;protein complex;Proteins;Publishing;Regulation;Regulon;Reporting;Repression;Repressor Proteins;response;Role;Signal Transduction;single-cell RNA sequencing;stem cell division;stem cell expansion;stem cell fate;stem cell proliferation;Testing;Thick;Tissues;transcription factor;Transcriptional Regulation;transcriptome;Yeasts

PROJECT_TITLE: Transcriptional regulation of neural progenitor divisions and cell fate in the developing cortex

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE My colleagues and I have identified many of the cellular components required to assemble β-barrel proteins, surface-exposed lipoproteins, and lipopolysaccharide in the outer membrane and we have provided evidence for a diffusive mechanism of phospholipid transport from the inner to the outer membrane. We wish to understand, in molecular detail, how these components function to assemble this asymmetric lipid bilayer outside of the cell in an environment that lacks ATP. We have used our knowledge of outer membrane biogenesis to demonstrate that the surface-exposed components are attractive new drug targets that not only kill the cell but also disrupt the outer membrane barrier, rendering strains more sensitive to existing antibiotics, and thus could be especially effective in combination therapies.

PI_NAMEs: SILHAVY, THOMAS J. (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Antibiotics;aqueous;Architecture;beta barrel;Biogenesis;biological adaptation to stress;Biological Models;cell envelope;cell killing;Cell surface;Cells;Collection;Combined Modality Therapy;Cytoplasm;Defect;DegP protease;enterobacterial common antigen;Environment;Enzymes;Escherichia coli;Face;Funding;Genes;Goals;Gram-Negative Bacteria;insight;Island;Knowledge;Ligase;Lipid Bilayers;Lipids;Lipopolysaccharides;Lipoproteins;Maintenance;Membrane;membrane biogenesis;Modeling;Molecular;Molecular Chaperones;mutant;Mutation;Nature;new therapeutic target;novel;novel antibiotic class;O Antigens;Pathway interactions;Peptides;Periodicity;periplasm;Phenotype;Phospholipids;Physiology;Process;protein protein interaction;Proteins;response;Role;sortase;Surface;Testing;tool;trafficking;translational study;Work

PROJECT_TITLE: Biogenesis and maintenance of the outer membrane of Gram-negative bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative The safety and health outcomes of hospitalized patients are contingent on having enough nurses staffed at the bedside to provide around the clock surveillance and deliver high-quality care; however, U.S. hospitals have historically chronically understaffed nurses. The COVID-19 public health emergency is further threatening the safety of hospitalized patients, with chronically overextended nurses reporting unprecedented rates of burnout and leaving hospital employment. Using multiple linked data sources of millions of patients, thousands of nurses, and hundreds hospitals during a pre-pandemic baseline, and 1 and 3 years after the pandemic onset, we evaluate the impact of the public health emergency on outcomes of hospital nurses; determine whether better nurse staffing and nurse-friendly work environments pre-pandemic buffered nurses from poor outcomes during the pandemic; and determine whether patient outcomes, measures of safety, quality, and value, track with changes in nurse outcomes in order to refine scientific understanding of potentially causal relationships and inform effective solutions to improve outcomes.

PI_NAMEs: LASATER, KAREN BLANCHETTE (contact)

PROGRAM_OFFICER_NAME: HAUGSTETTER, MONIKA

PROJECT_TITLE: Learning from Hospital Preparedness during COVID: Chronically Under-Resourced Nurses and Patient Safety

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Pain Research;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: ORTHOPEDICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Osteonecrosis of the femoral head (ONFH) is a disease in which a segment of bone within the femoral head (the ball portion of the hip joint) dies, resulting in painful arthritis. There has been increasing interest in delivering autogenous bone marrow aspirate concentrate (BMAC) harvested from the patient’s own pelvis to treat early stage ONFH, to try to save the femoral head and avoid hip replacement surgery. The goal of this study is to conduct a prospective, randomized multicenter clinical trial to compare the outcome of patients who have ONFH undergoing core decompression alone (drilling of the femoral head) versus core decompression supplemented with the patients’ own BMAC.

PI_NAMEs: GOODMAN, STUART B;JONES, LYNNE C. (contact);MONT, MICHAEL

PROJECT_TERMS: Arthritis;Autologous;Biological;Biology;Biometry;Blood Vessels;bone;Bone Marrow Aspiration;Bone necrosis;Case Series;Cell Therapy;Cells;Cessation of life;Characteristics;Circulation;Classification;Clinical;clinical practice;Clinical Trials;Clinical/Radiologic;common treatment;Consensus;Cytometry;Data Coordinating Center;Data Set;design;Diagnosis;Disease;Early Diagnosis;Early treatment;effective intervention;efficacy evaluation;Elements;end stage disease;Equipoise;evidence base;Failure;femur head;Frequencies;Goals;Grant;Harvest;healthcare burden;Heterogeneity;Hip Joint;Hip region structure;hip replacement arthroplasty;improved;Individual;Infrastructure;interest;International;joint destruction;Joints;Laboratories;Lesion;Life;Literature;Location;loss of function;Marrow;member;Methodology;Modeling;Multi-Institutional Clinical Trial;Multicenter Studies;Multicenter Trials;Musculoskeletal Diseases;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;operation;Operative Surgical Procedures;Outcome;Pain;Pathogenesis;Patient-Focused Outcomes;Patients;Pelvis;Persons;Pharmacologic Substance;Phenotype;preservation;prevent;Procedures;prospective;Publishing;radiologist;Radiology Specialty;Randomized;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;recruit;Reporting;Research Design;Risk Factors;Sampling;Societies;Specimen;Staging;Standardization;stem cells;subchondral bone;success;Techniques;Testing;Time;tissue regeneration;tissue repair;Total Hip Replacement;treatment arm;United States;Variant

PROJECT_TITLE: Autologous Bone Marrow Aspirate Concentrate for the Treatment of Osteonecrosis of the Femoral Head

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Keim-Malpass/Bourque PM-IMPACCT PROJECT NARRATIVE This proposed research is relevant to the public health because developing processes to detect clinical detection earlier using continuous predictive analytics monitoring at the bedside will reduce the harmful impact of this illness on morbidity and mortality in hospitalized patients. In this way, it is relevant to the NIH mission to apply research discoveries to protect and improve health.

PI_NAMEs: BOURQUE, JAMIESON MACDONALD;KEIM-MALPASS, JESSICA  (contact)

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: Predictive Monitoring: IMPact of Real-time Predictive Monitoring in Acute Care Cardiology Trial (PM-IMPACCT)

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Nutrition;Obesity

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Fat reserves release hormones called adipokines that act on neural circuits to regulate decisions on several physiological processes including hunger, immunity, and reproduction. If not tightly coupled to energy status, adipokine release is detrimental to the organism and leads to obesity and metabolic disorders. By studying how fat stores communicate nutrient state to an organism we will elucidate the molecular and cellular mechanisms that underpin healthy energy balance.

PI_NAMEs: RAJAN, AKHILA  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Adipocytes;adipokines;Adopted;age acceleration;Bacteria;Behavior;Cell Physiology;Cells;Chronic;Communication;Complex;coping;Coupled;detection of nutrient;diet-induced obesity;Disease;Drosophila genus;Eating;energy balance;Energy Metabolism;Event;Evolution;Fatty acid glycerol esters;Food;Food Energy;Food Supply;Future;Gene Expression;Goals;healthy lifestyle;Homeostasis;Hormones;Human;Hunger;Immunity;impaired capacity;Investigation;Maps;Membrane Fusion;Metabolic;Metabolic Diseases;Modeling;Molecular;neural circuit;novel strategies;Nutrient;nutrient deprivation;Nutritional;Obesity;Organism;Outcome;Pathway interactions;Physiological;Physiological Processes;Physiology;Prevalence;Process;protein function;Proteins;Regulation;Reproduction;response;Signal Transduction;System;Testing;tumor progression

PROJECT_TITLE: Cellular mechanisms governing nutrient sensing and organismal energy homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: OVERALL: PROJECT NARRATIVE The HD2A Research Adoption Support Center (RASC) assembles a uniquely qualified team with expertise in dissemination and implementation (D&I) science spanning substance use disorder and pain intervention research and practice, and across the four pillars of the US Health & Human Services National Overdose Prevention Strategy. Organized by four synergistic, dynamic cores, the RASC is steadfast and strategically focused on assessing, supporting and enhancing the D&I capability of the HD2A Innovation Projects—nimbly and adaptively responding to intervention research studies of any type, at any stage of development, in any setting, using any research design, and regardless of the intervention provider and/or its intended recipients. The RASC meets all stipulated requirements as outlined in the RFA, but has greater ambitions: To shift the paradigm in D&I science for substance use and pain intervention research, and thereby improve equitable access to the best health care available for persons and communities living with substance use disorders and pain.

PI_NAMEs: BECKER, SARA ;BECKER, WILLIAM C;BROWN, C. HENDRICKS;MCGOVERN, MARK P (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: addiction;Address;Adoption;Attitude;Awareness;Black Box;Case Study;Catalogs;Collaborations;Communities;community living;Complex;Consensus;Data;data harmonization;data infrastructure;design;Development;Dimensions;Dissemination and Implementation;dissemination science;Economics;Ensure;Epidemic;Equity;Evaluation;evidence base;Evidence based intervention;Evidence based practice;experience;Faculty;formative assessment;Goals;Harm Reduction;Health;health care availability;Human;implementation evaluation;implementation research;implementation science;implementation strategy;implementation study;implementation tool;improved;innovation;Intervention;Intervention Studies;Investments;Knowledge;Leadership;Learning;Life;Measurement;Measures;Methodology;Methods;Modeling;Monitor;National Institute of Drug Abuse;online resource;Opiate Addiction;Opioid;opioid epidemic;opioid mortality;opioid use disorder;Outcome;overdose death;overdose prevention;Pain;Pain management;Persons;Policies;prevent;Prevention;Prevention strategy;program dissemination;programs;provider intervention;Public Health;Publications;Qualifying;real world application;Records;Research;Research Design;Research Personnel;Research Project Grants;research study;resource guides;Resources;response;Scientist;service delivery;Services;Site;social capital;social stigma;Specific qualifier value;Standardization;stem;Stimulant;substance use;Substance Use Disorder;substance use prevention;symposium;System;Technical Expertise;Terminology;Theoretical model;Thinking;Translating;translational barrier;Translational Research;United States National Institutes of Health


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

PI_NAMEs: MCGOVERN, MARK P (contact)

PROJECT_TERMS: addiction;Address;Adoption;Advocacy;Atmosphere;career networking;Chemistry;Collaborations;Communication;Communities;Coordination and Collaboration;cost effectiveness;Data Collection;data infrastructure;data sharing;Dedications;design;Development;Dissemination and Implementation;dissemination science;Economics;Engineering;Equity;Evaluation;evidence base;Evidence based intervention;experience;Eye;Faculty;flexibility;Fostering;Foundations;Funding;Glues;Goals;Heart Research;Helping to End Addiction Long-term;Home;implementation research;implementation science;implementation tool;improved;Individual;Infrastructure;innovation;Intervention;Intervention Studies;Lead;Leadership;lectures;Logistics;Maintenance;Measures;Mediation;meetings;Mentors;Methods;Modeling;Monitor;multidisciplinary;National Institute of Drug Abuse;National Institute of Mental Health;Needs Assessment;open data;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;organizational structure;overdose prevention;Pain;Persons;Policies;Policy Maker;Prevention strategy;Process;Productivity;programs;Public Domains;Public Health;Publications;Qualifying;Quality Control;repository;Research;Research Institute;Research Personnel;Resource Sharing;Resources;response;scale up;Science;service delivery;Services;social media;Speed;substance use;Substance Use Disorder;support network;symposium;synergism;Technology Transfer;tool;Translational Research;treatment research;treatment services;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;Update;user-friendly;web portal;web site;Work

PROJECT_TITLE: HD2A RASC-Administrative Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Suicide;Suicide Prevention

PHR: PROJECT NARRATIVE Culturally grounded mental health prevention interventions hold significant promise to reduce suicide among American Indian/Alaska Native (AI/AN) youth, a group at highest risk in the nation. However, there is little research to understand how core components included in these interventions impact mental health outcomes and promote resiliency against suicide. The proposed study with White Mountain Apache Tribe research partners will focus on an innovative, culturally grounded AI youth suicide prevention intervention, “The Elders’ Resilience Curriculum,” to: a) identify core components that impact protective factors against suicide; b) develop a youth resilience theoretical model; c) culturally adapt measures to assess outcomes; and d) pilot a culturally acceptable and rigorous evaluation to inform future research and scaling of this intervention to other AI/AN communities.

PI_NAMEs: O’KEEFE, VICTORIA  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Adolescent;Adolescent Development;Affect;Age;Alaska Native;American Indians;Apache;Apache Tribe;Belief;career;Cessation of life;Cherokee Indian;Child;Clinical;cognitive interview;Communities;community based participatory research;Comprehension;cost;cultural values;Data;design;Development;Disparity;Distal;Educational Curriculum;Educational process of instructing;effectiveness study;Elderly;Evaluation;experience;Family;Feeling suicidal;Focus Groups;Goals;Health;high risk;improved;Indigenous;Individual;innovation;Intervention;Interview;K-Series Research Career Programs;Knowledge;Language;Life;Maps;Measurement;Measures;Mental Health;Mental health promotion;Mental Health Services;Mentored Research Scientist Development Award;Mentorship;Methods;Modeling;National Institute of Mental Health;native youth;Outcome;Outcome Assessment;Participant;Personal Satisfaction;prevent;Prevention;Prevention Research;preventive intervention;Program Evaluation;programs;promote resilience;protective factors;Public Health;Random Allocation;reducing suicide;Research;Research Methodology;Research Personnel;Research Support;Research Training;resilience;Resources;response;Review Literature;Risk;Risk Factors;Risk Reduction;scale up;Schools;Science;Seminole Tribe;Sorting;Specific qualifier value;Spirituality;suicidal behavior;suicidal risk;Suicide;suicide mortality;Suicide prevention;Techniques;Testing;Theoretical model;theories;therapy design;Training;tribal college;tribal community;Tribal Elders;Tribes;Underserved Population;United States Substance Abuse and Mental Health Services Administration;verbal;White Mountain Apache;Work;Youth

PROJECT_TITLE: The Elders' Resilience Curriculum: Toward Building Empirical Evidence for a Culturally Grounded American Indian Youth Suicide Prevention Intervention

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse

PI_NAMEs: BECKER, SARA  (contact)

PROJECT_TERMS: Action Research;addiction;Adoption;Advocacy;African American population;American;Asian Americans;Behavior Therapy;Black race;Catalogs;caucasian American;Clinical Trials Network;Communities;Continuity of Patient Care;COVID-19 pandemic;Data;Death Rate;Disparity;disparity gap;Dissemination and Implementation;dissemination science;Engineering;Equity;Evaluation;evidence base;Faculty;Funding;gaps in access;Goals;Harm Reduction;health equity;Healthcare;Healthcare Systems;Helping to End Addiction Long-term;implementation facilitation;implementation intervention;implementation measures;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Inequity;information gathering;innovation;integrated care;Intervention;Investments;Justice;Knowledge;Leadership;Learning;Link;marginalized population;Measures;Mediation;Methodology;Methods;Motivation;National Institute of Drug Abuse;Native Americans;Native Hawaiian;Needles;Not Hispanic or Latino;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid use disorder;Overdose;overdose death;overdose prevention;Overdose reduction;overdose risk;Pacific Islander;Pain;Pharmaceutical Preparations;pharmacologic;Phase;Policies;Prevention;program dissemination;psychosocial;Public Health;Public Health Practice;Publications;recovery services;Research;Research Institute;Research Personnel;resource guides;Resources;Role;Science;Scientist;Services;shared decision making;social stigma;Speed;Substance Use Disorder;substance use treatment;symposium;System;Technology Transfer;Time;Translating;Translational Research;Uninsured;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration

PROJECT_TITLE: HD2A RASC-SUD Implementation Support Core


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: NEW HAVEN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Autophagy is a catabolic cellular process that maintains homeostasis and delays aging through the selective degradation of intracellular material. The bridge-like lipid transfer protein ATG2 is essential to this process and tissue specific ablation of this autophagy protein decreases organismal lifetime and increases age-related tissue deterioration. This project seeks to elucidate the mechanism by which ATG2 delivers lipids to directly expand the nascent autophagosome.

PI_NAMEs: FULLER, DEVIN  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Ablation;Address;Age;age related;Aging;aging process;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Architecture;Artificial Membranes;Automobile Driving;Autophagocytosis;Autophagosome;Binding Sites;Biochemical;Biogenesis;Biological;Biological Assay;Biological Process;Biology;biophysical properties;career;Carrier Proteins;Cell Physiology;Cells;Cellular Stress;Co-Immunoprecipitations;Collaborations;Cytoplasm;cytotoxic;Data;Defect;design;Deterioration;Engineering;Environment;experimental study;Funding;Future;Genes;Goals;Growth;healing;Health;healthy aging;Homeostasis;Hydrophobicity;Impairment;in silico;In Vitro;Kinetics;Label;Length;life span;lipid transfer protein;lipid transport;Lipids;live cell imaging;Lysosomes;Maintenance;Maps;Measurement;Mediating;Melia;Membrane;Membrane Biology;Mentorship;Methods;Microscopy;Modeling;Molecular;Motility;Mutagenesis;Neurodegenerative Disorders;Neurons;novel;Organelles;Organism;Parkinson Disease;prevent;Process;Property;Proteins;Proteome;Proteomics;Publishing;Reaction;reconstitution;recruit;Research;Resolution;Rod;Side;Site;skill acquisition;Small Interfering RNA;Source;Specificity;Structure;success;System;Techniques;Technology;Testing;Therapeutic Intervention;Tissues;Training;Visual

PROJECT_TITLE: ATG2 transfers lipids from ER exit site membranes to directly expand the growing autophagosome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ORG_DEPT: PHARMACOLOGY

ORG_NAME: DREXEL UNIVERSITY

PHR: Skeletal metastases are detected in >90% of patients with advanced prostate cancer and eventually are determinant contributors to their demise. Current standards of care extend life expectancy but do not cure the metastatic stage of this disease. While the events sustaining skeletal metastasis have not been fully defined, our preliminary studies implicate prostate cancer cells lacking the Androgen Receptor (AR) or with this receptor functionally blocked and expressing the cytokine Interleukin-1beta (IL-1β) in establishing a microenvironment conducive to tumor colonization and resistance to AR-targeting therapies. We intend to reveal the molecular mechanistic underpinning of this process and identify novel therapeutic targets to be pursued in combination to the AR- targeting therapeutics currently available.

PI_NAMEs: FATATIS, ALESSANDRO  (contact)

PROGRAM_OFFICER_NAME: BENAVIDEZ, JUSTIN MICHAEL

PROJECT_TERMS: Adipocytes;advanced prostate cancer;Affect;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;Animal Model;Animals;antagonist;autocrine;bone;Bypass;cancer cell;Cancer cell line;Cancer Patient;Castration;celecoxib;cell stroma;Cell Survival;Cells;chemokine;cyclooxygenase 2;cytokine;deprivation;derepression;Dinoprostone;Disease;Dose;enzalutamide;Event;Excision;experimental study;Gene Expression;gene repression;Genes;Genetic Transcription;Goals;Growth;Habitats;Harvest;Hormones;Human;Human Cell Line;human tissue;IL1R1 gene;improved;inhibitor;Interleukin-1 beta;Knowledge;Lesion;Life Expectancy;LNCaP;Long-Term Care;Malignant - descriptor;Malignant neoplasm of prostate;Mesalamine;mesenchymal stromal cell;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;MicroRNAs;Mixed Neoplasm;Modality;Modeling;Molecular;Molecular Biology;Mus;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Osteoblasts;Osteoclasts;osteopontin;paracrine;patient derived xenograft model;Patients;PC3 cell line;Phenotype;pre-clinical;Process;promoter;prostate cancer cell;Prostate Cancer therapy;RANTES;receptor;receptor binding;receptor expression;Receptor Inhibition;Receptor Signaling;receptor-mediated signaling;recruit;Regulation;release factor;Reporting;Resistance;response;Role;skeletal;Structure;System;targeted treatment;Testing;Testosterone;Therapeutic;therapy outcome;Transcriptional Regulation;tumor;Tumor Tissue;Tumor-Derived;Up-Regulation;VCaP

PROJECT_TITLE: Interleukin-1beta and AR-negative tumor cells in metastatic castrate-resistant prostate cancer

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Pain Research;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse

PI_NAMEs: BECKER, WILLIAM C (contact)

PROJECT_TERMS: Academy;Accidents;Acute;Address;Adoption;Adverse effects;Advocacy;American;Attention;Behavior Therapy;Behavioral;career;Caring;Catalogs;Centers for Disease Control and Prevention (U.S.);Cessation of life;Charge;chronic pain;chronic pain management;Common Data Element;Complex;Data Analytics;Development;Diagnosis;Dimensions;disability;disparity gap;Dissemination and Implementation;dissemination science;Education;Epidemic;Equity;evidence base;evidence based guidelines;Funding;Goals;Guidelines;Harm Reduction;Health Status;Healthcare Systems;high risk;Impairment;implementation facilitation;implementation intervention;implementation measures;implementation outcomes;implementation science;implementation strategy;implementation trial;improved;information gathering;innovation;Institute of Medicine (U.S.);Intervention;Lead;Learning;life span;Link;Long-Term Effects;Managed Care;Measures;Mediation;medication for opioid use disorder;Medicine;member;Methodology;Methods;Modeling;Morbidity - disease rate;Motivation;Opioid;opioid epidemic;opioid overdose;opioid therapy;opioid use disorder;Overdose;overdose death;Pain;Pain Clinics;Pain management;Pain quality;pain relief;patient oriented;Patients;Pharmacological Treatment;Phase;Policies;population health;pragmatic implementation;prescription opioid;prescription opioid misuse;Prevalence;Prevention;primary care provider;program dissemination;Public Health;Publications;Qualifying;Quality of Care;Quality of life;Recommendation;Recovery Support;Reporting;Research;Research Personnel;resource guides;Risk Factors;Science;Scientist;shared decision making;Signal Transduction;skills;social stigma;stem;symposium;Time;Translating;treatment guidelines;United States National Institutes of Health;uptake

PROJECT_TITLE: HD2A RASC - Pain Implementation Support Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Synthetic biology holds the promise of transforming the development of diagnostic and treatment strategies for various diseases. This project applies synthetic biology approaches to reprogram fate decisions toward progressive cellular deterioration, a key factor in many diseases, such as cancers, diabetes, and neurodegenerative diseases. Key insights obtained from this project will define foundations for chemical or gene- based strategies to treating diseases related to progressive cellular deterioration.

PI_NAMEs: HAO, NAN  (contact);HASTY, JEFF M;PILLUS, LORRAINE ;TSIMRING, LEV S

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Abscisic Acid;Affect;Behavior;Biological Process;Cell Death;Cell Fate Control;cell injury;Cell Reprogramming;Cells;Cellular Morphology;Cessation of life;Chemicals;Complex;Computer Models;Core Protein;Coupled;Custom;Data;Deacetylase;Decision Making;design;Deterioration;Diabetes Mellitus;diagnostic development;diagnostic strategy;Disease;Dose;Doxycycline;Engineering;Eukaryota;experimental study;Foundations;gene conservation;Gene Expression;gene interaction;Genes;Genetic Engineering;Genetic Recombination;Genetic Transcription;Growth;Heme;improved;insight;Life;Lysine;Malignant Neoplasms;Mammals;Mediating;Microfluidics;Microscopy;Mitochondria;Mitotic;Modeling;models and simulation;Molecular;Mothers;Neurodegenerative Disorders;Organism;Pattern;Periodicals;Phenotype;Physiological;Play;Population;predictive modeling;Process;programs;promoter;protein expression;Proteins;Regulation;Research;Resources;Ribosomal DNA;Role;Saccharomyces cerevisiae;Saccharomycetales;Structure;synthetic biology;Synthetic Genes;System;Testing;Time;tool;treatment strategy;Yeasts

PROJECT_TITLE: Reprogramming cell-fate decisions through predictive modeling and synthetic biology

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: BROWN, C. HENDRICKS (contact)

PROJECT_TERMS: addiction;Address;Adoption;African American;Area;career;Complex;contextual factors;Core Assembly;COVID-19 pandemic;Data;Data Collection;data harmonization;data infrastructure;Data Reporting;Decision Making;design;Disparity;Dissemination and Implementation;dissemination science;Economics;Equity;ethnic minority;Evaluation;Evaluation Reports;evaluation/testing;Evidence based intervention;Evidence based practice;experience;formative assessment;Future;Goals;Harm Reduction;Health Benefit;implementation barriers;implementation evaluation;implementation outcomes;implementation research;implementation science;implementation strategy;innovation;insight;Insurance Coverage;Intervention;Interview;Investments;Knowledge;male;marginalized population;Measurement;Measures;medication for opioid use disorder;Methodology;Methods;Modeling;models and simulation;Monitor;mortality;Motivation;multidisciplinary;opioid use disorder;overdose death;Pain;Persons;Phase;Policies;Primary Prevention;programs;Public Health;Qualifying;racial minority;Recovery Support;Reporting;Research;Research Methodology;Research Project Grants;Resource-limited setting;Resources;Role;scale up;Science;Scientist;screening;Standardization;stimulant use disorder;substance use;Substance Use Disorder;Surveys;System;Testing;text searching;tool;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: HD2A RASC-Research and Evaluation Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Aging;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases;Regenerative Medicine

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Influenza A virus (IAV) infection and pneumonia represent the leading infectious causes of death in the United States, and disproportionately affect the elderly. Regulatory T (Treg) cells coordinate the resolution of lung injury, but the mechanisms underpinning the loss of pro-endothelial repair function in Treg cells from aged hosts remains unknown. We aim to uncover the transcriptional and functional changes that determine the gain and loss of pro-endothelial cell repair function in Treg cells following viral pneumonia throughout the lifespan.

PI_NAMEs: MORALES-NEBREDA, LUISA  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 2019-nCoV;Acute Lung Injury;Acute Respiratory Distress Syndrome;adaptive immune response;Adoptive Transfer;Affect;Age;age related;age related changes;aged;Aging;Alveolar;alveolar epithelium;angiogenesis;Angiogenic Factor;Anti-viral Therapy;Autopsy;Biological Process;Blood capillaries;Blood Vessels;Bronchoalveolar Lavage Fluid;career;Case/Control Studies;Cause of Death;cell age;Cell Therapy;Cells;Clinical;Data;Dedications;design;Development;Diffuse;Down-Regulation;Elderly;Endothelial Cells;endothelial repair;Endothelium;experience;Experimental Designs;experimental study;Failure;Flow Cytometry;Fluorescence-Activated Cell Sorting;Functional disorder;gain of function;Gene Expression Profile;Gene Expression Profiling;Genetic Transcription;Goals;Human;Immune;Impairment;improved;Inflammation;Influenza;Influenza A virus;influenza infection;influenzavirus;Injury;insight;Knowledge;Learning;life span;Link;loss of function;Lung;lung injury;lung repair;Lymphocytic Infiltrate;Measurement;Mediating;Mentors;Methods;Molecular;mortality;mouse model;Mus;novel;older patient;Older Population;Organ;Outcome;overexpression;Pathology;Patients;Phase;Phenotype;Physicians;Pneumonia;Population;Predisposition;Printing;Production;programs;Proteins;Publishing;Pulmonary Inflammation;Recovery;recruit;Regulatory T-Lymphocyte;repair function;repaired;Research;Resolution;response to injury;Risk Factors;Scientist;Severities;skills;small molecule;Specimen;Techniques;Testing;Thrombosis;tissue repair;Training;transcriptome sequencing;Transgenic Organisms;United States;Vascular Endothelial Growth Factors;VEGFA gene;Viral Pneumonia;Virus;Virus Diseases;Youth

PROJECT_TITLE: Mechanisms of regulatory T-cell mediated endothelial repair following viral pneumonia in aged hosts

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Kidney Disease;Orphan Drug;Rare Diseases

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: The experiments of this proposal will facilitate our understanding of how metabolism contributes to kidney cancer. As new cancer therapies are emerging that can target epitranscriptomic and metabolic pathways, these studies will facilitate the development of novel therapeutic approaches for one of the most common cancers in men and women.

PI_NAMEs: SUDARSHAN, SUNIL  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: advanced disease;amino acid metabolism;aminoacid biosynthesis;Anabolism;Automobile Driving;Biological;Biology;cancer cell;Cancer Patient;cancer therapy;Data;deprivation;Development;dietary;Enzymes;epitranscriptome;epitranscriptomics;experimental study;Face;Gene Expression;Genes;Glucose;glucose metabolism;Glycolysis;Goals;Growth;High Prevalence;Human;Hypermethylation;in vivo;innovation;Kidney;Link;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;men;Messenger RNA;Metabolic;Metabolic Pathway;Metabolism;Methodology;Methylation;methylome;Methyltransferase;Modeling;Modification;Molecular;mRNA Stability;multidisciplinary;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;novel therapeutic intervention;Nucleotides;Oncogenic;Outcome;Pathway interactions;patient derived xenograft model;Patients;PF4 Gene;pharmacologic;Phenotype;Prognosis;Renal Carcinoma;Renal Cell Carcinoma;Reporting;ribosome profiling;RNA;RNA methylation;Role;Serine;small molecule;Time;transcription factor;transcriptomics;Transgenic Model;Translations;tumor;Tumor Biology;tumor growth;tumor metabolism;Tumor Promotion;Woman;Work

PROJECT_TITLE: Interaction between the Epitranscriptome and Metabolism in L-2HG Driven Kidney Cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE OVERALL Although potential new possibilities for human disease treatments are being discovered more rapidly than ever before, the translation of these possibilities into clinical application remains cumbersome and slow. Some of this inefficiency is due to uncertainties that arise because available animal models may not accurately and sufficiently represent details of the human disease. The pilot JAX Center for Precision Genetics (JCPG) is a multi-component Center that will build on a robust infrastructure designed to serve the biomedical community by refinement of a public-facing pipeline that operates to first identify pressing needs, and then design, create and distribute new mouse models that are specifically tailored to the disease characteristics of the patient population.

PI_NAMEs: LUTZ, CATHLEEN M (contact);MURRAY, STEPHEN A

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Acceleration;Advanced Development;advanced disease;Advocate;Alleles;animal facility;Animal Model;Area;Bioinformatics;Biology;Cells;Characteristics;Clinical;clinical application;Clinical Treatment;Clinical Trials;Collaborations;Communities;Complement;Data;Data Analyses;Data Collection;data dissemination;data framework;data sharing;design;Development;Disease;disease model;disease phenotype;DNA Sequence Alteration;drug discovery;Elements;expectation;experience;flexibility;Foundations;Funding;Generations;Genetic;Genetic Models;genetic resource;genetic technology;genome editing;Genomics;Goals;human disease;human model;in vivo;Infrastructure;innovation;Laboratories;Laboratory mice;Link;Maintenance;Mammalian Genetics;Marketing;Medical Genetics;model development;model organism;Modeling;Molecular;mouse genetics;mouse model;Mus;Newly Diagnosed Disease;next generation;novel;Outcome;outreach;patient population;Patients;Pharmacology;Phenotype;Physiology;pre-clinical;precision genetics;Precision therapeutics;preclinical study;Preclinical Testing;predictive modeling;Process;programs;repository;Reproducibility;Research;Research Design;Research Personnel;Resources;Services;success;System;The Jackson Laboratory;Therapeutic;therapeutic development;therapeutic evaluation;Time;tool;Translations;Uncertainty;Validation;Work

PROJECT_TITLE: The Jackson Laboratory Center for Precision Genetics


NIH_SPENDING_CATS: Genetics;Precision Medicine

PI_NAMEs: LUTZ, CATHLEEN M (contact)

PROJECT_TERMS: Accounting;Achievement;Awareness;Bioinformatics;Clinical;Clinical Trials Design;Communication;Communities;Consultations;Dedications;Development;Disease;disease model;drug testing;Drug usage;Ensure;Evaluation;experience;Foundations;Generations;Genetic Models;genetic resource;genetic technology;genetic variant;Goals;Grant;Guidelines;Human Genetics;Human Resources;Infrastructure;innovation;Laboratories;Laboratory mice;Leadership;Letters;Marketing;meetings;member;Mission;model development;Modeling;Monitor;mouse model;multidisciplinary;Mus;operation;outreach;Participant;Play;precision genetics;preclinical study;Procedures;Process;Production;Productivity;Program Reviews;programs;Progress Reports;Publications;Recommendation;Records;recruit;Reporting;Research;Resource Development;Resources;Review Committee;Role;Schedule;Scientist;Services;synergism;Testing;The Jackson Laboratory;timeline;tool;translational potential;United States National Institutes of Health;Variant;web portal;web site;working group

PROJECT_TITLE: Coordination Section

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-U]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Back Pain;Chronic Pain;Neurosciences;Pain Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Intervertebral disc degeneration is one of the greatest contributors to low back pain, yet how the intervertebral disc can generate pain remains poorly understood. This work will measure activation of sensory nerves involved in transmitting pain to the central nervous system, in an animal model of IVD degeneration. This would reveal new information about intervertebral disc “cross-talk” with the nervous system that may suggest novel interventions for treatment of discogenic pain.

PI_NAMEs: SETTON, LORI A. (contact);TANG, SIMON YUE-CHEONG

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Action Potentials;Acute;Affect;afferent nerve;Afferent Neurons;Algorithms;Anatomy;Animal Model;Animals;arm;Behavior;Behavior monitoring;Behavioral;Brain imaging;Calcium;Cells;Central Nervous System;Chronic;cohort;Confocal Microscopy;contrast enhanced;disability;discogenic pain;Dissociation;Distant;electric field;Exposure to;Fluorescence Microscopy;fluorophore;Generations;Genetic Transcription;Goals;Harvest;Image;Impairment;In Vitro;in vivo;in vivo fluorescence;Incubated;Infiltration;Inflammation Mediators;injured;Injury;Intervention;Intervertebral disc structure;intervertebral disk degeneration;Ion Channel;Knowledge;Low Back Pain;Measures;Methods;microCT;Modeling;Molecular;Molecular Target;Monitor;Morphology;Motion;mouse model;Mus;Nerve;Nerve Fibers;Nervous System;Neurons;neurotransmission;neurotrophic factor;novel;novel strategies;Operative Surgical Procedures;Organ;Organ Culture Techniques;Pain;Pathology;Pattern;Phenotype;Population;Pre-Clinical Model;promoter;protein expression;Puncture procedure;Rattus;response;Role;second harmonic;sensory stimulus;Site;Sodium Channel Blockers;Spinal Cord;spinal disk injury;Spinal Ganglia;Testing;Tetrodotoxin;Tissues;Transgenes;transmission process;TRPV1 gene;two-photon;Visualization;voltage;Work

PROJECT_TITLE: Intervertebral Disc Degeneration and Cross-Talk with the Nervous System

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Genetics;Orphan Drug;Precision Medicine;Rare Diseases

PROJECT_TERMS: Address;Adoption;Animal Model;Benchmarking;Biology;Biomedical Research;CLIA certified;Client;Clinical;clinical application;Clinical Data;clinical phenotype;clinical practice;Clinical Trials;Collaborations;Collection;Communities;Data;data exchange;disease model;Drug Kinetics;drug testing;experience;Faculty;Fee-for-Service Plans;Felis catus;Future;Genetic;genomic data;Genomic medicine;Goals;Grant;Health;Hospitals;Human;human disease;in vivo;Individual;Industry;Industry Collaboration;Infrastructure;Knowledge;Laboratories;Lead;Medical center;Modality;model development;Modeling;Mouse Strains;Mus;operation;Patients;Pharmacology;Phenotype;Positioning Attribute;pre-clinical;precision genetics;Preclinical Testing;Production;Rare Diseases;Recommendation;repository;Research;Research Personnel;Resources;Role;Sampling;Series;Services;somatic cell gene editing;Testing;The Jackson Laboratory;Therapeutic;tool;Toxicology;translational goal;Treatment Efficacy;Validation;Work

PROJECT_TITLE: Preclinical/Co-Clinical Section


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

ORG_CITY: HOUSTON

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Annually, over 250 million patients receive dental care and yet, little is known about diagnostic failures in dental clinics. Estimates from the medical profession suggest that between 10-15% of patients are misdiagnosed, and there are significant reasons to suggest that diagnostic failures are prevalent in dentistry too. In this study, we seek to identify diagnostic failures, and examine the link between diagnostic failures and clinical outcomes.

PI_NAMEs: WALJI, MUHAMMAD  (contact)

PROGRAM_OFFICER_NAME: IGNACZAK, AARTEE

PROJECT_TITLE: Diagnostic Failures in Dentistry


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Comparative Effectiveness Research;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Stroke

PHR: PROJECT NARRATIVE Transcatheter left atrial appendage occlusion with the Watchman device was developed and approved for reducing ischemic stroke risk in patients with atrial fibrillation who are not good candidates for long-term anticoagulation. As this technology becomes increasingly adopted in clinical practice, efficient methods for assessing the long-term safety and effectiveness of the Watchman device following regulatory approval are needed. This research will use a national registry of left atrial appendage occlusion, Medicare claims data, and qualitative data from patients to assess how different data sources and methodologic approaches can be utilized to evaluate outcomes related to the Watchman device in real-world practice.

PI_NAMEs: FARIDI, KAMIL  (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Achievement;Adopted;Adverse event;adverse outcome;Advisory Committees;Agreement;American;Anticoagulation;anxiety reduction;Area;Atrial Fibrillation;auricular appendage;Award;Biometry;Biostatistical Methods;cardiac device;Cardiology;Cardiovascular system;career;career development;Clinical;Clinical Investigator;clinical practice;Code;college;comparative effectiveness;comparative effectiveness analysis;comparison intervention;cost;Data;data registry;Data Sources;Databases;design;Devices;Effectiveness;Eligibility Determination;Evaluation;Event;experience;Faculty;follow-up;Future;Goals;Hemorrhage;high risk;Hospitals;improved;Incidence;innovation;insight;interest;Interview;Ischemic Stroke;K-Series Research Career Programs;Left;Link;Machine Learning;machine learning method;Measures;Medical;medical schools;Medicare;Medicare claim;Medicine;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Modeling;Monitor;mortality;novel;Oral;Outcome;Outcome Assessment;Outcome Measure;Outcomes Research;Patient Care;patient oriented;patient oriented research;Patient Outcomes Assessments;patient registry;Patient-Focused Outcomes;Patients;Performance;Pharmacoepidemiology;Pharmacy facility;Physical Function;Population;post-market;preservation;Procedures;Program Development;programs;Qualitative Methods;Qualitative Research;Quality of life;randomized, clinical trials;Registries;Reporting;Research;Research Personnel;Research Project Grants;Resources;Risk;Risk Reduction;Safety;Site;skills;Specificity;Statistical Methods;Stroke;stroke risk;success;surveillance data;Technology;Training;Training Programs

PROJECT_TITLE: Optimizing Available Data Sources for Post-Marketing Surveillance: Real-World Use of Left Atrial Appendage Occlusion

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

PI_NAMEs: CHESLER, ELISSA J (contact)

PROJECT_TERMS: Aloral;Animal Model;Benchmarking;Bioinformatics;Catalogs;Clinical;Clinical Research;Collaborations;Complex;Computer software;Coupled;Data;data integration;data quality;data resource;data tools;Databases;Defect;design;Development;Disease;disease model;Equation;Evaluation;experience;Genes;Genetic;genetic variant;Genetic Variation;genome database;genome resource;Genomics;Goals;Heterogeneity;Human;human disease;Human Genetics;human model;improved;Informatics;Infrastructure;Intake;International;knowledge graph;Laboratories;Laboratory mice;Mind;model development;model organism;Modeling;mouse genetics;mouse genome;mouse model;Mus;novel;Ontology;optimism;Outcome;phenome;phenomics;Phenotype;pre-clinical;precision genetics;Process;programs;Quality Control;Research Personnel;Resources;Services;Software Design;System;The Jackson Laboratory;tool;user-friendly;Validation;Variant;Work

PROJECT_TITLE: Bioinformatics Section


PROJECT_TERMS: Archives;Awareness;Behavioral;Bioinformatics;Biological Markers;Client;Clinical Trials;Collaborations;Communities;Complement;cost;CRISPR/Cas technology;data access;Development;Disease;disease model;Duchenne muscular dystrophy;Environment;experience;Faculty;Fee-for-Service Plans;Feedback;Fees;Funding;Gene Expression;Generations;genome editing;Goals;Hand;Histology;Home Page;Hospitals;improved;Individual;Infrastructure;Knockout Mice;Laboratories;Laboratory mice;Link;Liquid substance;Maintenance;Marketing;Microscopy;Mission;Modeling;mouse model;Mus;Mutant Strains Mice;operation;outreach;Patients;Pharmacology;Phenotype;Physiology;precision genetics;Preclinical Testing;preservation;Process;Production;Program Development;programs;public repository;quality assurance;Rare Diseases;Reagent;Recording of previous events;Reporting;repository;Research;Research Personnel;Resource Development;Resources;Sales;Service delivery model;service programs;Services;somatic cell gene editing;Spinal Muscular Atrophy;Structure;Technology;The Jackson Laboratory;Therapeutic;tool;treatment center;United States National Institutes of Health;user-friendly;web site;Work

PROJECT_TITLE: Resource and Service Section


ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Narrative Cancer can be caused by a certain class of DNA mutations, called “structural variants”, that break apart DNA, then re-join it incorrectly. This can cause DNA to fold improperly and can contribute to genes being turned on inappropriately; however, when and where this leads to altered gene activation is not clear. This proposal will investigate when, where, and how structural variants cause DNA misfolding and inappropriate gene activation in cancer cells.

PI_NAMEs: DIXON, JESSE R (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: 3-Dimensional;Address;Alleles;Architecture;cancer cell;cancer genome;cancer subtypes;Cell Line;Cells;Chromatin Loop;Communication;Complex;CRISPR/Cas technology;Development;Disease;Distal;DNA;DNA Methylation;DNA methylation profiling;DNA Sequence Alteration;DNA Sequence Rearrangement;Engineering;Enhancers;Event;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic variant;Genome;Genome engineering;genome-wide;genomic locus;Germ Lines;Goals;Growth;Haplotypes;Heterogeneity;Human;Human Cell Line;human disease;individual patient;Inter-tumoral heterogeneity;Knowledge;Lead;Malignant Neoplasms;Methods;Minority;Modeling;multiple omics;Mutation;new therapeutic target;Normal tissue morphology;novel;novel strategies;Oncogenes;patient prognosis;Patients;personalized medicine;Phase;Phenotype;programs;promoter;Regulator Genes;Regulatory Element;Reporter;response;risk stratification;Role;Sampling;SET gene;Structure;Testing;Therapeutic;tumor;tumor heterogeneity;tumorigenesis;Variant

PROJECT_TITLE: Investigating the effects of structural variants on 3D genome organization and gene regulation in cancer genomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(70)R]


ADMINISTERING_IC: DC

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Pediatric

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: Project Narrative  Deficits in cortical speech processing are hallmarks of heritable developmental disorders including auditory processing disorder, specific language impairment, and autism, which involve additive effects of many genes. The short-term goal of my research is to elucidate genetic contributions to communication sound processing in higher auditory cortex by comparing neural responses to vocalizations in songbirds, an animal model of speech processing, that differ in genetic background and have specific differences in vocal behavior. In the long term, my findings will fuel investigation into genetic mechanisms of sensory limitations in central auditory disorders that underlie deficits in processing vocal sounds and sound sequences.

PI_NAMEs: EDWARDS, JACOB AARON (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acoustics;Adolescent;Adult;Affect;Animal Model;Animals;Auditory;Auditory area;Auditory Perceptual Disorders;autism spectrum disorder;awake;Behavior;Behavioral;Behavioral Genetics;Birds;career;Carrying Capacities;Characteristics;Child;Code;code development;Communication;communication behavior;Data;Data Analyses;Development;developmental disease;Disease;Electrophysiology (science);experience;experimental study;Fathers;Fostering;Gene Mutation;Genes;Genetic;Genetic Identity;genetic makeup;genome-wide;Goals;Grant;Hearing;Hearing problem;Heritability;Home;Human;Hybrids;Impairment;Infant;insight;Investigation;Journals;Language;language processing;Lead;Learning;learning ability;Life;Life Experience;long term memory;Maps;Measures;Morphology;neural;neuroimaging;Neurons;Outcome;Parents;Pattern;Perception;Predisposition;prevent;Process;Production;Publications;receptive field;Relaxation;Research;response;Sensory;sensory mechanism;sensory system;Shapes;Single Parent;skills;social;Social Interaction;Songbirds;sound;Source;specific language impairment;Speech;speech processing;Speech Sound;statistical learning;Stimulus;Structure;Support System;symposium;syntax;Testing;Time;Training;tutoring;Twin Studies;Universities;vocal learning;vocalization;Voice;Work;Writing

PROJECT_TITLE: Auditory cortical tuning to communication sounds and genetic constraints on the vocal learning landscape


PI_NAMEs: MURRAY, STEPHEN A (contact)

PROJECT_TERMS: addiction;Alleles;Animal Model;Bioinformatics;bioinformatics tool;Biological Models;Biometry;Clinic;Clinical;clinical application;Clinical Trials;Collection;Communities;community engagement;Consultations;CRISPR/Cas technology;design;Development;Disease;disease model;Faculty;flexibility;Funding;Genes;Genetic;Genetic Engineering;Genomics;Goals;Grant;High-Throughput Nucleotide Sequencing;human disease;human model;improved;Individual;Infrastructure;innovation;Institution;Intervention;knockout gene;Laboratories;Laboratory mice;Leadership;Maintenance;Maps;model design;model development;Modeling;mouse model;Mus;Mutant Strains Mice;neurogenetics;novel therapeutics;operation;Outcome;Pathology;Phenotype;Physiology;pre-clinical;precision genetics;preclinical study;Preclinical Testing;preservation;Process;programs;Recording of previous events;repository;Research;Research Personnel;Resource Development;Resources;Services;Structure;success;System;Technology;Testing;The Jackson Laboratory;Therapeutic;Time;tool;Translating;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Disease Modeling Unit


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Childhood Leukemia;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PHR: NARRATIVE Over the past five years, our R35-supported research led to a new paradigm for the treatment of B-cell tumors: Unlike other cancer-types, B-cell malignancies are highly susceptible to targeted engagement of negative selection, a B-cell-intrinsic mechanism to protect against harmful autoantibodies and autoimmune disease. Contrary to established dogma, mechanisms of negative selection are not only active in preventing autoimmune disease but also represent an entirely novel class of therapeutic targets in B-cell malignancies. The main impetus of this renewal application is now to leverage these new concepts for the development of treatment strategies that will overcome conventional mechanisms of drug-resistance in B-ALL, CLL and mantle cell lymphoma.

PI_NAMEs: MÜSCHEN, MARKUS  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Affect;Autoantibodies;Autoimmune Diseases;autoreactive B cell;B lymphoid malignancy;B-Cell Acute Lymphoblastic Leukemia;B-Cell Antigen Receptor;B-Cell Lymphomas;B-Cell Neoplasm;B-Lymphocytes;BCL6 gene;Biomass;cancer type;Cell Size;cell transformation;cell type;Cells;cellular engineering;Development;Disease;Drug resistance;Energy Supply;Gatekeeping;Genetic;Genetic Transcription;improved outcome;kinase inhibitor;Laboratories;Length;Lymphoid;Lymphoma cell;Maintenance;Malignant - descriptor;Mantle Cell Lymphoma;Measurement;Metabolic;Mitochondria;Morphology;Natural regeneration;novel;Oncogenic;Outcome;Patient-Focused Outcomes;Patients;Periodicals;pharmacologic;Phase;Phosphotransferases;Predisposition;premalignant;prevent;programs;Proliferating;Recovery;Relapse;Research Support;Signal Transduction;Sleep;small molecule inhibitor;Somatic Cell;Stress;System;targeted cancer therapy;Therapeutic Intervention;therapeutic target;therapy development;treatment strategy

PROJECT_TITLE: Metabolic gatekeepers in B-cell malignancies


ADMINISTERING_IC: AA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;HIV/AIDS;Infectious Diseases;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: This T32 Training Program is relevant to public health in the United States because it will train the next generation of researchers with skills to help reduce the impact of alcohol on HIV infection and related outcomes. We seek to train researchers who come from diverse backgrounds and can work with communities to reduce health disparities related to alcohol and HIV infection.

PI_NAMEs: COOK, ROBERT L (contact);LYON, DEBRA E;MALDONADO-MOLINA, MILDRED M

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TITLE: Translational Science Training to Reduce the Impact of Alcohol on HIV Infection


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with highly variable clinical course and limited treatment options. This proposal aims to develop and validate a multimodal, noninvasive imaging protocol to investigate a pathway-specific route for IPF therapy. The outcomes of this work have the potential to accelerate development of IPF interventions.

PI_NAMEs: AKAM-BAXTER, EMAN  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acceleration;Address;antagonist;Area;Binding;Biochemical;Biological;Biology;Bleomycin;Chemistry;Clinical;Clinical Research;Clinical Trials;Collagen;cost;Data;Development;Diagnosis;Disease;disease heterogeneity;Disease Progression;Dose;drug candidate;Drug Design;drug development;drug efficacy;Drug Targeting;Early treatment;fibrogenesis;Fibrosis;Fortification;Future;high risk;idiopathic pulmonary fibrosis;Image;Imaging Device;imaging modality;imaging probe;Immunohistochemistry;improved;in vivo;indium-bleomycin;individual response;Inflammatory;Injections;injured;Integrin alphaVbeta3;Integrins;Intervention;Knowledge;Lung;Lung Diseases;lung imaging;lung injury;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;Measurement;Measures;Modeling;Molecular Biology Techniques;molecular imaging;Monitor;mouse model;Multimodal Imaging;multimodality;Mus;Natural History;nintedanib;non-invasive imaging;novel therapeutics;Outcome;Output;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Phenotype;Pirfenidone;Positron-Emission Tomography;pre-clinical assessment;Pre-Clinical Model;Probability;Progressive Disease;Protocols documentation;Pulmonary Fibrosis;quantitative imaging;Radiation;radiation-induced lung injury;Reporting;Research;Research Project Grants;Resolution;response;Risk;Route;Signal Transduction;skills;Stratification;success;targeted treatment;Testing;Therapeutic;Time;tool;Training;treatment response;uptake;Validation;Work

PROJECT_TITLE: Multimodal quantitative PET/MR imaging of pulmonary fibrosis


NIH_SPENDING_CATS: Aging;Neurosciences

ORG_STATE: MO

PHR: PROJECT NARRATIVE Part of the NIH mission is to seek fundamental knowledge about the nature and behavior of living systems, and to apply that knowledge to enhance human health and lengthen life. Our proposed research is relevant to this mission because it seeks to understand novel yet conserved pathways of protein degradation in yeast and plants that can be developed as models to study ageing and provide information relevant to a wide range of human aggregation-prone pathologies, including Alzheimer’s, amyotrophic lateral sclerosis, Huntington’s, Parkinson’s diseases, and related multi-system proteinopathies. As such, information obtained from our continued studies on the autophagic turnover of dysfunctional proteasomes (proteaphagy) and CDC48 (p97/VCP in humans) and from our discovery of novel autophagic receptors/adaptors should be directly relevant to efforts aimed at improving human health by helping identify novel therapeutic strategies for a host of amyloid-related diseases.

PI_NAMEs: JEZ, JOSEPH MARTIN (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Aging;Alzheimer's Disease;Amyloid;Amyotrophic Lateral Sclerosis;Antibodies;Arabidopsis;Autophagocytosis;Autophagosome;Behavior;Binding;Binding Proteins;Biochemical;Catalogs;Cell Cycle;Cell membrane;Cell Nucleus;Cells;Chromosome Mapping;Cues;Cytoplasm;Cytoplasmic Granules;cytotoxic;Dedications;Defect;diagnostic biomarker;Disease;Docking;Enzymes;Event;Excision;familial amyotrophic lateral sclerosis;Family;fitness;Fluorescence Microscopy;Funding;Genetic;Goals;hallmarks of aging;Health;Heart;Homeostasis;Human;Huntington Disease;Impairment;improved;innovation;Knowledge;Life;Ligase;Liquid substance;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane;Microscopic;Mission;Modeling;Molecular Chaperones;multicatalytic endopeptidase complex;multisystem proteinopathy;Mutation;Nature;Nervous System Disorder;novel;novel therapeutic intervention;Organism;Orthologous Gene;Outcome;Parkinson Disease;particle;Pathology;Pathway interactions;Physical condensation;Plants;Polymers;Process;protein aggregation;protein complex;protein degradation;Proteins;Proteolysis;proteostasis;proteotoxicity;Quality Control;receptor;recruit;Recycling;Research;response;Role;Route;Signal Transduction;Stress;Surface;targeted treatment;Testing;Therapeutic Intervention;Ubiquitin;ubiquitin ligase;United States National Institutes of Health;valosin-containing protein;Vesicle;Work;Yeasts

PROJECT_TITLE: Autophagic Clearance of Proteasomes and CDC48 as Models for Amyloidogenic Protein Quality Control.

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Data Science

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PI_NAMEs: GLASS, HANNAH CRANLEY;KANAYA, ALKA M. (contact);WHOOLEY, MARY A

PROGRAM_OFFICER_NAME: HARTSHORN, CHRISTOPHER

PROJECT_TERMS: Address;Area;Biometry;career;career development;Clinical;Clinical Informatics;clinical practice;Clinical Research;Clinical Sciences;Data Science;design;Doctor of Pharmacy;Doctor of Philosophy;doctoral student;empowerment;Enrollment;Epidemiology;Exposure to;Fellowship;Foundational Skills;Future;Generations;Goals;Grant;Health;Health Professional;Health system;improved;Informatics;Knowledge;Leadership;Licensing;Master of Science;Mentors;Mentorship;Methodology;Methods;National Research Service Awards;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;professional students;programs;Research;Research Methodology;Research Personnel;Research Project Grants;responsible research conduct;Schools;skill acquisition;Students;Techniques;TNFSF15 gene;Training;Training Programs;Translational Research;United States National Institutes of Health

PROJECT_TITLE: NRSA Training Core


ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

PHR: NARRATIVE This work will identify the molecular receptors and sensory neurons that disease vector mosquitoes use to detect the body heat and humidity from human hosts, and establish their roles in promoting mosquito blood- feeding. As blood-feeding supports disease transmission, these basic science findings have potential relevance for vector control efforts by, for example, identifying molecular and cellular targets for developing new chemical repellents, masks or baits.

PI_NAMEs: GARRITY, PAUL  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Aedes;Affect;Afferent Neurons;Air;Anopheles gambiae;base;Basic Science;Behavior;Behavioral;behavioral response;Biology;Bite;Blood;Body Temperature;cellular targeting;Chemicals;Chromosomes;Collaborations;Color;comparative;Cues;Culicidae;Data;Defect;Dengue;Detection;disease transmission;Disease Vectors;Distant;Drosophila genus;Drosophila melanogaster;Dryness;Esthesia;Family;feeding;fly;Genes;Glutamate Receptor;Goals;High temperature of physical object;Human;Humidity;Hydration status;Ingestion;Insecta;insight;Invertebrates;Ion Channel;Joints;Knock-in;Knock-out;Knowledge;Malaria;Masks;Mediating;Molecular;Molecular Probes;Molecular Target;mutant;Neurons;Orthologous Gene;Persons;Physiological;Publications;receptor;Reporter;Reproduction;Research Personnel;Resolution;response;Role;sensor;Sensory;sensory stimulus;Specificity;stimulus sensitivity;success;System;Temperature;Testing;TRP channel;TRPA channel;vector;vector control;vector mosquito;Work

PROJECT_TITLE: The molecular and cellular basis of short-range host cue sensing in mosquito vectors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)M]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Understanding the health and health care consequences of the COVID-19 pandemic, and whether universal access to affordable health insurance for poor and low-income persons mitigates these consequences, is essential to inform policymaking regarding how to protect Americans when they experience health or economic setbacks or when economic or public health crises strike. Access to affordable health insurance for poor and low-income persons currently differs across states because only 35 states and the District of Columbia adopted the Medicaid expansion to all working-age adults with incomes below 138% of poverty permitted under the Affordable Care Act (ACA). Using data from two highly regarded, representative national surveys— the National Health Interview Survey (NHIS) and the Medical Expenditure Panel Survey (MEPS)—we propose to assess the protective effects of the ACA Medicaid expansion on the following outcomes for adults and children following the onset of the COVID-19 pandemic: (1) health insurance coverage; (2) access to and use of health care, health care expenditures, and financial stress; and (3) health outcomes, including physical and mental health.

PI_NAMEs: ESCARCE, JOSE JULIO (contact)

PROGRAM_OFFICER_NAME: KARACA, ZEYNAL

PROJECT_TITLE: The Medicaid expansion in the age of COVID-19: Effects on coverage, access, use, financial stress, and health.

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Pain Research;Telehealth

ORG_NAME: BOSTON MEDICAL CENTER

PHR: There is a growing evidence base that mind and body practices are effective treatment for chronic medical conditions. Yet implementation into clinical care has not widely occurred. Electronic health approaches may also facilitate integration of mind and body practices into patient care. This award will be key to providing the dedicated protected time necessary to expand the candidate's research and increase her mentoring capacity. Her research and mentoring will expand into the implementation of mind and body practices for chronic medical conditions in clinical care and into electronic health to facilitate patient uptake of theses practices.

PI_NAMEs: MORONE, NATALIA E. (contact)

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: Adoption;Area;Award;Biomedical Research;Boston;career;career development;Cellular Phone;Chronic;Chronic low back pain;chronic pain;chronic pain management;Clinical;clinical care;clinical practice;Clinical Research;Clinical Sciences;Complementary Medicine;Data;Dedications;Education;education research;Educational process of instructing;effective therapy;Effectiveness;eHealth;Ensure;Evaluation;evidence base;experience;Faculty;Fostering;Foundations;Funding;Future;Goals;Grant;Healthcare Systems;Hypertension;implementation science;Integrative Medicine;Integrative Therapy;Internet;Intervention;Journals;Knowledge;Learning;Medical;Medical Students;Mentors;mind/body;mindfulness;mindfulness intervention;Mindfulness Training;mindfulness-based stress reduction;Morones;next generation;Nonpharmacologic Therapy;Patient Care;patient engagement;patient oriented;patient oriented research;Patients;Peer Review;Postdoctoral Fellow;Pragmatic clinical trial;Procedures;Program Development;programs;Publications;Publishing;Research;Research Personnel;Research Project Grants;Research Support;Resources;Services;skills;Source;success;Technology;telehealth;therapy development;Time;Training;Translating;Translational Research;Underrepresented Populations;Universities;uptake;Work;Workforce Development

PROJECT_TITLE: Mentoring and Patient-Oriented Research in Mind and Body Practices