ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Wound Healing and Care

ORG_CITY: FAYETTEVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: Public Health Relevance: Non-healing wounds, such as diabetic foot ulcers, have emerged as a major health concern, particularly for older adults. This project will develop image analysis tools that can be combined with advanced optical imaging to provide a non-invasive optical biopsy of wounds to guide treatment and wound product development.

PI_NAMEs: QUINN, KYLE PATRICK (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Address;Adoption;American;analysis pipeline;Animal Model;Architecture;Artificial Intelligence;automated analysis;automated segmentation;Biochemical;Biopsy;Cell Count;cell motility;Cell Physiology;Cell Proliferation;cell type;Cellular Infiltration;Cellularity;chronic wound;Classification;Clinic;Clinical;Clinical assessments;cofactor;Collagen;Collection;Consumption;Contrast Media;convolutional neural network;cost;Coupled;crosslink;Data;Debridement;deep learning;deep neural network;Dermatologic;Dermis;Diabetic Foot Ulcer;disease classification;Elastin;Epidermis;Excision;Feedback;Fibrosis;Fluorescence;Functional disorder;Future;Generations;generative adversarial network;Geometry;Goals;Granulation Tissue;Hair follicle structure;Health;Histologic;histological image;histological stains;Histology;Histopathology;Image;Image Analysis;image processing;imaging Segmentation;in silico;in vivo;in vivo optical imaging;Infection;Injury;insight;Keratin;Label;Laboratory Research;Lipids;Machine Learning;Manuals;Measures;Metabolic;Metabolism;Methods;microscopic imaging;multiphoton microscopy;NADH;neural network;non-healing wounds;non-invasive imaging;older adult;Operative Surgical Procedures;Optical Biopsy;optical imaging;Outcome;Pathologist;pentosidine;point of care;product development;public health relevance;quantitative imaging;radiological imaging;Research;Research Personnel;second harmonic;Series;Skin;Skin Tissue;skin wound;Source;Stains;Structure;Techniques;Technology;Testing;Three-Dimensional Imaging;Time;Tissues;tool;Training;transfer learning;two-photon;virtual;Visual;wound;wound care;wound closure;wound healing

PROJECT_TITLE: Non-invasive automated wound analysis via deep learning neural networks

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Rare Diseases;Sleep Research

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Narcolepsy with cataplexy is a chronic debilitating sleep-wake disorder affecting over 3 million people worldwide. This project is aimed to understand the neural mechanisms contributing to the pathophysiology of this disorder using animal models. Thus, the outcomes of this proposal will undoubtedly improve our knowledge on the neurological basis of narcolepsy with cataplexy and will aid in the development of better prognostic, diagnostic and therapeutic options for this disorder.

PI_NAMEs: RAMALINGAM, VETRIVELAN  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Address;Affect;Animal Model;Animals;antagonist;Attenuated;Behavior;Cataplexy;Cell Nucleus;Chocolate;Chronic;Complex;Data;Development;Diagnostic;Disease;Drowsiness;Emotional;emotional stimulus;Enterobacteria phage P1 Cre recombinase;Epilepsy;Exhibits;experimental study;Fiber;Functional disorder;Genetic;Glutamates;High Prevalence;Human;hypocretin;Hypothalamic structure;Image;improved;in vivo;Knockout Mice;Knowledge;Lateral;Lesion;Life;Maintenance;melanin-concentrating hormone;melanin-concentrating hormone receptor;Methods;Midbrain structure;Motor Activity;mouse model;Mus;Muscle Tonus;Narcolepsy;Nature;neural;neural circuit;neurochemistry;Neurologic;neuromechanism;neuronal cell body;Neurons;novel therapeutics;optogenetics;Outcome;Parkinson Disease;Pathology;Pathway interactions;Patients;Pattern;Persons;photoactivation;Photometry;Play;Pontine structure;Population;positive emotional state;prevent;prognostic;Publishing;Rattus;Regulation;REM Sleep;Role;Running;Signal Transduction;Sleep;Sleep Disorders;Tegmentum Mesencephali;Testing;Therapeutic;Transgenic Mice;Work

PROJECT_TITLE: Neural Mechanisms Underlying Cataplexy Control by MCH Neurons

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Public Health Relevance Our team of experts will develop novel approaches and gain biological insights into immune system control by Tregs. Our findings will have broad implications for the use of Tregs in controlling adverse immune responses leading to translational applications to harness the full power of Tregs for hematopoietic stem cell and solid transplantation as well as autoimmunity settings.

PI_NAMEs: BLAZAR, BRUCE R (contact);HIPPEN, KELI L

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: 3-Dimensional;Acute Graft Versus Host Disease;Affect;Alanine;Allogenic;Amino Acid Transporter;Amino Acids;Amplifiers;Anabolism;Antigen-Presenting Cells;Antigens;Aspartate;Autoimmunity;Biological;Carbon;Catabolism;CD19 gene;CD22 gene;CD28 gene;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Proliferation;Cell Respiration;Cell surface;cell type;Cells;chimeric antigen receptor;Clinic;Clinical Trials;Creatinine;cytokine;cytokine release syndrome;Cytolysis;cytotoxic;Cytotoxic T-Lymphocytes;Data;disease model;DNA;DNA Methylation;Engineering;Equilibrium;first-in-human;Folic Acid;gain of function;Gene Expression;Glucose;Glutamates;Glutathione;Glutathione Metabolism Pathway;Glycine;graft vs host disease;graft vs leukemia effect;Granzyme;Hematopoietic stem cells;Histones;Human;Immune response;Immune system;immunological synapse;Inflammatory;Infusion procedures;innovation;insight;Integrins;leukemia;leukemia relapse;Ligation;Link;Lipid Bilayers;Lipids;loss of function;Lymphocyte Function;Lymphoma;Metabolic;Metabolic Pathway;metabolic profile;Methionine;methyl group;Mitochondria;Modeling;Mus;neurotoxicity;novel;novel strategies;Nucleotides;Outcome;Oxidation-Reduction;Oxidative Phosphorylation;particle;Pathway interactions;Peptide/MHC Complex;perforin;Phase;Phospholipids;Polyamines;Population;Positioning Attribute;pre-clinical;prevent;Process;Production;programs;Proteins;public health relevance;purine metabolism;Purines;Reaction;Regulatory T-Lymphocyte;Relapse;Reporting;Respiration;Rest;RNA;Seminal;Serine;Signal Transduction;Solid;T cell differentiation;T-Cell Receptor;T-Lymphocyte;Testing;Thymus Gland;Tissues;transcriptome;translational applications;Transplantation;Transplantation Tolerance;Treatment Efficacy

PROJECT_TITLE: Enhancing Treg Therapeutic Efficacy in GVHD

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Natural Products;Neurosciences;Prevention;Substance Misuse

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Reducing the risks of cannabis-impaired driving will depend on reliable methods to detect impairment and evidence-informed guidance on how dose, route of administration, and temporal factors are associated with impairment. We will investigate portable devices that use psychomotor and oculomotor measures, and blood biomarkers, for their predictive value in identifying impaired driving in our advanced driving simulator laboratory. Successful completion of our study will provide innovative findings that can promote traffic and workplace safety.

PI_NAMEs: BROOKS-RUSSELL, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Acute;Automobile Driving;Benchmarking;Biological Markers;Blood;Blood capillaries;Blood specimen;Cannabinoids;Cannabis;cannabis self-administration;cognitive function;cohort;Collection;Country;design;Detection;Devices;Dose;driving performance;driving safety;driving under influence;Drug Kinetics;Enrollment;Evaluation;Event;Eye Movements;Flowers;Forensic Medicine;Goals;Goggles;Health Personnel;Human Resources;impaired driving performance;Impairment;innovation;innovative technologies;Institutional Review Boards;instrument;Laboratories;Law Enforcement;Laws;Learning;Legal;Literature;marijuana smoker;Marijuana Smoking;marijuana use;marijuana user;Marketing;Measurement;Measures;Medical;Methods;multidisciplinary;novel;novel strategies;oculomotor;Pattern;Performance;Persons;Pharmacodynamics;pharmacokinetic model;Phase;Plant Resins;Police;portability;Positioning Attribute;Predictive Value;prevent;Protocols documentation;Psychomotor Performance;Psychotropic Drugs;Public Health;Pupil;Reaction Time;Recording of previous events;Recreation;recruit;Reflex action;Reporting;Research;Research Design;Risk;Risk Reduction;Role;Route;Safety;Scanning;Smoke;Standardization;Subgroup;System;Tablets;Testing;Tetrahydrocannabinol;THC concentration;Time;Universities;Venous;Whole Blood;Workplace

PROJECT_TITLE: Novel approaches to assessing cannabis impaired driving

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Mitochondria are a central hub for sensing cellular damage and can control host defense against bacterial infection. Mutations that affect a critical component of mitochondrial lipid function can cause the X-linked genetic disorder, Barth Syndrome, characterized by recurrent bacterial infections. Our studies will shed light on how mitochondrial functions shape the development of immunity to bacterial infections.

PI_NAMEs: O'RIORDAN, MARY  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: 3-Methylglutaconic aciduria type 2;Affect;Agonist;Anabolism;Animals;antagonist;Anti-Bacterial Agents;Antibacterial Response;Antioxidants;Apoptosis;Architecture;Bacteria;Bacterial Infections;Biochemical;cardiolipin synthase;Cardiolipins;cell injury;Cellular biology;Cellular Stress;clinically relevant;Complex;confocal imaging;Coupled;cytokine;defined contribution;Development;Disease;Enzymes;Exhibits;extracellular;Extracellular Space;Functional disorder;Generations;Genetic;Genetic Diseases;Goals;Homeostasis;Host Defense;Human;Immune;immune function;Immune response;Immune signaling;Immunity;immunoregulation;In Vitro;in vivo;Infection;Infectious Skin Diseases;Inflammasome;Inflammation;Injury;Innate Immune Response;Inner mitochondrial membrane;insight;Link;Lipids;Macrophage;Membrane;Metabolism;methicillin resistant Staphylococcus aureus;Mitochondria;Modeling;Modification;mouse model;Mus;Mutation;Neutropenia;Outcome;Outer Mitochondrial Membrane;oxidation;pathogen;pathogenic bacteria;Patients;Peptides;pharmacologic;Phospholipids;Positioning Attribute;Predisposition;Production;Productivity;Reactive Oxygen Species;Recurrence;Regulation;respiratory;Respiratory Chain;respiratory protein;response;Role;Shapes;Signal Transduction;Soft Tissue Infections;Staphylococcus aureus infection;Stress;superresolution microscopy;Surface;System;Tail;targeted treatment;Testing;therapeutic target;TLR4 gene;trafficking;Vesicle;Work;wound healing

PROJECT_TITLE: Mitochondrial stress shapes host responses to bacterial infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: GALVESTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Relevance: Kidney fibrosis is a common downstream manifestation of several renal diseases that affects millions of people and their overall health. We have identified novel mechanisms whereby circulating suPAR causes distinct patterns of kidney fibrosis, explore the underlying mechanisms leading to fibrosis, and attempt to inhibit these pathways to protect people from renal diseases.

PI_NAMEs: WEI, DAVID CHANGLI (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Affect;Affinity;Animal Model;Binding Proteins;Biological Assay;Blood;Bone Marrow;CD44 gene;cell injury;Cell Physiology;Cells;Cellular Structures;Chronic Kidney Failure;Clinical;cohort;combat;CRISPR/Cas technology;Cultured Cells;Development;Disease;Disease Progression;effective therapy;Epithelial Cells;Event;Exhibits;experimental study;Family;Fibrosis;Fingers;Focal and Segmental Glomerulosclerosis;Gene Modified;glomerulosclerosis;Grant;Health;Healthcare;HK2 gene;In Vitro;in vivo;Incidence;Individual;Infusion procedures;injured;Injury;Innate Immune Response;insight;Integrin alphaV;Integrin alphaVbeta3;Integrin beta Chains;integrin beta6;Integrins;interstitial;Kidney;Kidney Diseases;Kidney Failure;kidney fibrosis;Knock-out;Knockout Mice;Measures;Mediating;Medical;member;Modality;Modeling;Molecular;mortality;mouse model;Myeloid Cells;Nephrons;Neurotoxins;novel;novel therapeutics;overexpression;Participant;Pathway interactions;Patients;Pattern;Peptides;periostin;Persons;Plasma;Play;podocyte;post-transplant;prevent;Prevention strategy;programs;Protein Isoforms;protein protein interaction;Proteins;Publishing;Recurrence;Reporting;Risk Factors;Role;Signal Transduction;Signaling Protein;Stream;Surface Plasmon Resonance;Testing;TGFBI gene;Therapeutic;Time;Toxin;Transgenic Mice;Translating;treatment strategy;Tubular formation;United States;Ureteral obstruction;Urokinase Plasminogen Activator Receptor

PROJECT_TITLE: suPAR and renal fibrosis

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Contraception/Reproduction;Dementia;Estrogen;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The degree to which female reproductive aging leads to macrostructural changes in brain morphology, brain connectivity, and ultimately cognitive functioning is severely understudied. By examining cognitively normal women undergoing ovarian hormone suppression for endometriosis, the present study will model a core aspect of reproductive aging, providing critical insights into how the depletion of ovarian hormones impacts the brain and cognition. This unique, genetically informed, cognitive neuroscience approach will advance our knowledge of the endocrine basis of cognition and facilitate a targeted approach to identifying individuals who may be particularly vulnerable to neural and cognitive effects of ovarian hormone depletion.

PI_NAMEs: JACOBS, EMILY G;PANIZZON, MATTHEW S (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Adult women;Age;Agonist;Alzheimer's Disease;Alzheimer's disease risk;analog;anatomic imaging;Anatomy;Animals;Architecture;Attention;Behavior assessment;Behavioral;Brain;brain morphology;Brain region;brain shape;Characteristics;Chronology;Clinical;Clinical Trials;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive neuroscience;cognitive performance;cognitive process;cognitive testing;Control Groups;Data;dementia risk;dentate gyrus;Diffusion;Dorsal;Endocrine;Endometrial;endometriosis;Ensure;entorhinal cortex;Episodic memory;Estradiol;Estrogen decline;Estrogen Receptors;Estrogens;Evaluation;executive function;Female;Fiber;Fogs;Functional Magnetic Resonance Imaging;Genetic;Genetic Predisposition to Disease;Genetic Risk;Goals;Gonadal Steroid Hormones;Gonadotropin Hormone Releasing Hormone;health assessment;Hippocampus;Hormonal Change;Hormone Antagonists;Hormone replacement therapy;Human;Impaired cognition;Individual;insight;interest;Knowledge;Linkage Disequilibrium;Literature;Maps;Measures;medial temporal lobe;Memory;Menopause;millimeter;Modeling;Morphology;multimodal neuroimaging;multimodality;neural;neuroimaging;Neurophysiology - biologic function;neuroprotection;Neuropsychology;Observational Study;Outcome;Ovarian hormone;Participant;Pathway interactions;Performance;Perimenopause;Play;polygenic risk score;Postmenopause;Prefrontal Cortex;Premenopause;Production;Progesterone;Progesterone Receptors;Proliferating;Psychosocial Assessment and Care;randomized, clinical trials;receptor;Reporting;reproductive senescence;Resolution;response;Rest;Role;Sampling;Scanning;Secondary to;Shapes;Short-Term Memory;spectrograph;Structure;Synapses;Techniques;Testing;Time;Tissues;tool;treatment planning;treatment response;Variant;white matter;Woman;Women's Group;Women's Health

PROJECT_TITLE: Impact of ovarian hormone suppression on regional and global brain architecture and cognition

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative The goal of our proposed research is to advance the knowledge regarding the role played by splicing alterations in neurological diseases with the objective of developing novel mRNA-targeted therapeutics. Our first aim is to use a computational approach to identify new neuron-specific poison exons for which mis-splicing is associated with neurodevelopmental and neurodegenerative diseases. We will then use patient-derived cellular models of frontotemporal dementia associated with MAPT mis-splicing as proof-of-principle to demonstrate the therapeutic potential of a novel class of splicing modulator compounds.

PI_NAMEs: MORINI, ELISABETTA  (contact);TELO BAPTISTA LIMA DA SILVA, MARIA CATARINA

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Address;Affect;Alternative Splicing;Atlases;Biological;Biological Assay;Brain;Catalogs;Cell model;ClinVar;Clustered Regularly Interspaced Short Palindromic Repeats;Coupling;CRISPR/Cas technology;Data;Data Set;Defect;Development;Disease;disease phenotype;Equipment and supply inventories;Event;Excision;Exclusion;exon skipping;Exons;Familial Dysautonomia;Frontotemporal Dementia;gain of function;gain of function mutation;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Diseases;genetic variant;genomic data;Genotype;Goals;Human;Human Engineering;in silico;In Vitro;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Knowledge;Lead;Maps;MAPT gene;Measures;Mediating;Messenger RNA;Methods;migration;Modeling;Molecular;mutant;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurodevelopmental Disorder;neurogenesis;neuron development;neuronal survival;Neurons;Nonsense-Mediated Decay;novel;novel therapeutic intervention;Pathogenesis;Pathogenicity;Pathology;patient derived induced pluripotent stem cells;Patients;Phenotype;Play;Poison;premature;protein expression;Protein Isoforms;Proteins;Proteome;Regulation;Research;RNA Processing;RNA Splicing;RNA, Messenger, Splicing;RNA-targeting therapy;Role;Structure;synaptic function;synaptogenesis;targeted treatment;tau aggregation;tau Proteins;Tauopathies;Terminator Codon;Testing;Therapeutic;therapeutic development;therapeutic evaluation;Therapeutic Intervention;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translating;Translations;Untranslated RNA;Variant;Work

PROJECT_TITLE: Developing Splicing-Targeted Therapeutic Strategies for Neurological Diseases

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PI_NAMEs: RONIS, MARTIN J J (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TITLE: The role of oxidative stress in alcohol-induced osteopenia

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Infectious Diseases;Lung;Microbiome;Vaccine Related

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE A subset of individuals with chronic obstructive pulmonary disease are susceptible to recurrent exacerbations of their respiratory symptoms. This proposal will investigate whether changes in the nasal inflammatory response and/or nasal microbiome contribute to frequent exacerbations and can predict the severity of the exacerbation course.

PI_NAMEs: DRUMMOND, MICHAEL BRADLEY (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Acute;Affect;Age;airway inflammation;Biological;Biological Markers;Chronic Obstructive Pulmonary Disease;Clinical;clinically relevant;Cluster Analysis;Communities;Constitution;cytokine;Data;Deterioration;Development;disease phenotype;Disease susceptibility;disorder risk;Effector Cell;Environment;Fingerprint;Frequencies;Functional disorder;functional status;Host Defense;Immune;Immune response;Immunity;Individual;Inflammatory;Inflammatory Response;Innate Immune Response;Knowledge;Link;live attenuated influenza vaccine;Lung Diseases;Measures;Mediator;microbiome;microbiome composition;Modeling;Mucosal Immunity;nasal microbiome;non-smoker;Nose;novel;Pattern;Phenotype;poor health outcome;Population;Positioning Attribute;Predisposition;Recurrence;Research;respiratory;respiratory microbiome;Respiratory Signs and Symptoms;response;Risk;Role;Sampling;Severities;Structure;Structure of mucous membrane of nose;Symptoms;trait;Variant;Viral;Viral load measurement;Viral Respiratory Tract Infection;Virus Diseases;Virus Replication

PROJECT_TITLE: The Role of Nasal Mucosal Immunity and Microbiome on the Frequent Exacerbation Phenotype of COPD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Social Determinants of Health

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Health disparities continue to be a significant challenge. Among the issues that continue to be of concern to the Public Health system of the United States is the paucity of diversity in our nation’s biomedical sciences and engineering workforce. The Virginia Tech ESTEEMED program will produce outstanding underrepresented minorities who will pursue careers in biomedical engineering.

PI_NAMEs: ARENA, SARA ;SMITH, EDWARD J (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Achievement;Active Learning;Address;Admission activity;Bachelor's Degree;Biochemistry;Biological Sciences;Biomedical Engineering;black men;bridge program;career;Chemistry;college;Communication;Development;Discipline;Doctor of Philosophy;education research;Eligibility Determination;Engineering;Environment;experience;Face;Faculty;faculty mentor;Familiarity;Foundations;Funding;Goals;Graduate Degree;health disparity;Health system;innovation;Institution;Investigation;Leadership;Learning;Mathematics;Mentors;Minor;Minority;neuroimaging;Oral;peer;Postbaccalaureate;pre-doctoral;Process;Productivity;Program Development;programs;Public Health;Recording of previous events;recruit;Research;Research Training;Review Literature;Science;Selection Criteria;skill acquisition;skills;Social Justice;statistics;STEM field;student mentoring;Students;success;symposium;Tissue Engineering;tool;Training;Training Programs;Translating;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States;United States National Institutes of Health;Update;Virginia;Writing

PROJECT_TITLE: VT-ESTEEMED


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Chronic kidney disease (CKD) affects more than 35 million Americans and can progress to complete renal failure and the need for dialysis or transplantation. The kidney is innervated by sensory nerves and sympathetic nerves that are affected by CKD and can in turn alter renal function and CKD progression. This application tests whether nerve activity is altered in various CKD models, whether denervation alters hypertension, renal function, and CKD progression, and whether inflammation mediates increases in nerve activity.

PI_NAMEs: TAN, RODERICK JASON (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: Affect;afferent nerve;American;Aristolochic Acids;Blood flow;Blood Pressure;blood pressure reduction;chemokine;Chemoreceptors;Chronic Care;Chronic Kidney Failure;Clinical Research;Clinical Trials;cytokine;Denervation;Diabetes Mellitus;Dialysis procedure;disease model;Disease Progression;Efferent Neurons;Exclusion;Excretory function;experimental study;Fiber;Glomerular Filtration Rate;Glucose;Goals;hemodynamics;Hypertension;hypertensive;Immunosuppression;improved;improved outcome;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;Injury;insight;Kidney;Kidney Diseases;Kidney Failure;Knock-out;Laboratories;Measures;Mediating;Mediator;Modeling;Morbidity - disease rate;mortality;Mus;Nephrectomy;Nerve;neuroregulation;novel;novel therapeutics;Pathogenesis;Patients;Pelvis;Perfusion;Population;pressure;prevent;programs;Proteinuria;Public Health;pyrrolidine dithiocarbamate;Rag1 Mouse;receptor;Receptor Activation;Renal Blood Flow;Renal function;Renal Plasma Flow;Renin-Angiotensin System;Reperfusion Injury;Research;response;Rodent;Role;Sensory;Sodium;Sodium Chloride;Stimulus;symporter;Testing;Therapeutic Effect;Tissues;Transplantation;Water

PROJECT_TITLE: Effect of Renal Nerves on Chronic Kidney Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

PHR: Neuromodulation modalities, such as repetitive transcranial magnetic stimulation (rTMS) can induce long-term plastic changes and selectively alter brain network function which in turn may improve symptoms in Alzheimer’s disease (AD). However, despite the wide application of rTMS in humans, the mechanisms underlying rTMS-induced plasticity in healthy aging and AD remain uncertain. The proposed study examines the ability of rTMS to induce plasticity and modulate brain network function in preclinical and prodromal AD in the context of the aging brain.

PI_NAMEs: DICKERSON, BRADFORD C;TOUROUTOGLOU, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Adult;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer’s disease biomarker;amnestic mild cognitive impairment;Amyloid;Amyloid beta-Protein;Atrophic;Attenuated;behavioral outcome;Biological;Brain;brain dysfunction;cerebral atrophy;Cerebrum;clinical diagnosis;Clinical Trials;Cognitive;Data;Dementia;Exhibits;experimental study;Frequencies;Funding;Future;Goals;healthy aging;Hippocampus;Human;Impairment;improved;Individual;innovation;insight;Lateral;Left;Long-Term Potentiation;Magnetic Resonance Imaging;Measures;Modality;Modeling;Nerve Degeneration;neural circuit;Neuronal Plasticity;neuroregulation;older adult;Outcome;Parietal;Pathology;Patients;Positron-Emission Tomography;pre-clinical;prodromal Alzheimer's disease;repetitive transcranial magnetic stimulation;Research;response;Risk;Site;symptomatic improvement;Synapses;tau Proteins;Testing;Therapeutic;Time;Work

PROJECT_TITLE: Neuromodulation of brain network function in preclinical and prodromal Alzheimer's Disease


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative Shigella flexneri and related species are major sources of human diarrheal disease, affecting more than 100,000,000 people each year. This bacterium infects and grows within human intestinal epithelial cells, but many steps in this process are poorly understood. By characterizing the mechanisms of nutrient sensing and nutrient acquisition in the host cells, we will gain important knowledge about adaptation of bacteria to the host environment and potential means for interrupting the disease process.

PI_NAMEs: PAYNE, SHELLEY M. (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acids;Affect;Antibiotics;Bacteria;Biological Models;Biopsy;Carbon;Cell Density;Cell surface;Cells;Colon;Cytosol;Data;detection of nutrient;diarrheal disease;Disease;Drug resistance;Dysentery;enteric pathogen;Enterobacteriaceae;Environment;Epithelial Cells;Epithelium;Excretory function;experimental study;extracellular;Fermentation;Formates;Gene Expression;Genes;Glycolysis;Goals;Growth;gut microbiota;Human;human pathogen;human tissue;Immunity;Immunization;In Vitro;Infection;Inflammation;Innate Immune Response;Interruption;intestinal epithelium;Intestines;Invaded;Investigation;Knowledge;Learning;Libraries;Link;Measures;Mediating;Metabolism;microbiome;Modeling;Molecular;Motility;mutant;Mutation;novel;Nutrient;pathogen;Pathogenesis;Pathway interactions;Persons;Physiological;Prevention;Prevention strategy;Process;Production;quorum sensing;Reagent;receptor;resistant Shigella;Resources;response;Role;screening;Shigella;Shigella flexneri;Shigella Infections;Signal Pathway;Signal Transduction;Source;Tissues;transcriptome;treatment strategy;vaccine access;Vaccines;Virulence;Virulence Factors;virulence gene;Work

PROJECT_TITLE: ROLE OF CARBON METABOLISM AND VIRULENCE OF SHIGELLA FLEXNERI

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_DEPT: SURGERY

PHR: NARRATIVE: The mechanism of thoracic aortic aneurysm and dissection is unknown and there is no medical treatment. We propose to use patient induced pluripotent stem cells to create tissue engineered blood vessels and implant these blood vessels into novel nude rabbits to determine the mechanisms of TAAD and identify novel treatments.

PI_NAMEs: YANG, BO  (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Affect;Aneurysm;Aorta;Aortic Aneurysm;Arteries;ascending aorta;Biomechanics;Bioreactors;Blood Vessels;Bromouridine sequencing;Cardiovascular system;Cause of Death;Cell Differentiation process;Cell Lineage;Cell Physiology;Cells;Cessation of life;Code;Control Groups;Coronary Arteriosclerosis;CRISPR/Cas technology;Data;density;Disease;Dissection;drug testing;embryonic stem cell;Enrollment;Extracellular Matrix;Family;Foundations;gene correction;Gene Mutation;Genes;genome editing;GKLF protein;Goals;Heart;Human;human induced pluripotent stem cells;Impairment;Implant;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inferior;inhibitor;Knock-in;Knock-out;Knowledge;Lipids;Loeys-Dietz Syndrome;loss of function mutation;Mechanics;Medical;Modeling;Molecular;mouse model;Muscle Cells;mutant;Mutate;Mutation;mutation correction;Neural Crest;novel;novel therapeutics;Oryctolagus cuniculus;Pathogenicity;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Persons;Phenotype;prevent;Property;Proteins;Pulsatile Flow;receptor;Research;response;Rest;Ruptured Aortic Aneurysms;screening;Signal Transduction;Smooth Muscle Myocytes;stem cells;Susceptibility Gene;Technology;TGFBR2 gene;Therapeutic;Thoracic aorta;Thoracic Aortic Aneurysm;Tissue Engineering;Tissue Transplantation;Tissues;Transforming Growth Factor beta;Transforming Growth Factors;United States

PROJECT_TITLE: Defining mechanisms of aortic root aneurysm in Loeys-Dietz syndrome using patients’ induced pluripotent stem cells and genome editing

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Contraception/Reproduction;Prevention

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE The focus of this research proposal is to delineate the contribution of cells of the innate immune system (macrophages & monocytes) in the sequence of events that occur in the pubertal rodent testis after exposure to the Sertoli cell toxicant, mono-(2-ethylhexyl) phthalate (MEHP). Phthalates are a class of compounds used in medical and consumer products and, as a result, are found ubiquitously in the environment. The work of this research proposal is relevant to human health as it is anticipated to provide mechanistic insights that will be valuable for predicting and preventing human reproductive health risks to environmental toxicants.

PI_NAMEs: RICHBURG, JOHN H (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Adult;Age;age related;aged;Animals;Antigen Presentation;Apoptosis;Attention;Basement membrane;Biology;Blood-Testis Barrier;CCL2 gene;Cell division;cell injury;Cell Physiology;Cell secretion;Cells;chemokine;consumer product;cytokine;Data;Dendritic Cells;design;Development;Dose;Environment;Evaluation;Event;Exhibits;experimental study;Exposure to;Extravasation;Future;Germ Cells;Goals;Health;Homeostasis;Hour;Human;Immune system;immunoreactivity;Incidence;Individual;Infertility;Infiltration;Inflammatory;Inflammatory Infiltrate;Injury;Innate Immune System;insight;interstitial;ITGAM gene;Kinetics;Knowledge;Leucocytic infiltrate;Leukocytes;Macrophage;Maintenance;Mediating;Medical;mono-(2-ethylhexyl)phthalate;monocyte;Mus;National Institute of Environmental Health Sciences;Natural Killer Cells;neutrophil;novel;Phagocytes;Phenotype;phthalates;Play;Predisposition;prevent;Prevention;Process;Production;Progress Reports;Proteins;Puberty;Publishing;Rattus;Recovery;recruit;repaired;Reporting;Reproductive Health;Research;Research Project Grants;Research Proposals;response;Risk;Rodent;Role;Seminiferous tubule structure;sertoli cell;Signal Transduction;Spermatogenesis;Spermatogenic Cell;Steroid biosynthesis;Strategic Planning;System;Testing;Testis;Therapeutic;tissue regeneration;Toxic Environmental Substances;toxicant;Translating;Treatment Protocols;Tubular formation;Work

PROJECT_TITLE: SERTOLI CELL TOXICANT INJURY AND MECHANISMS OF TESTICULAR GERM CELL APOPTOSIS

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: We propose to develop improved sequence based machine learning models to build gene network models to more accurately predict the impact of enhancer perturbation by CRISPR or genetic variation. We will develop methods to train and validate these models by detecting altered TF activity from high time resolution chromatin accessibility, TF ChIP-seq, and H3K27ac data in a stem cell differentiation system and in large consortium datasets (e.g. ENCODE). This project will significantly contribute to our understanding of regulatory element function and how sequence variation impacts disease.

PI_NAMEs: BEER, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Affect;Algorithms;ATAC-seq;Base Sequence;Binding;Binding Sites;Biological Assay;Biological Models;Cell model;Cells;ChIP-seq;Chromatin;Chromatin Loop;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;combinatorial;Computing Methodologies;CRISPR interference;Data;Data Set;design;Development;Disease;Elements;Embryo;embryonic stem cell;Endoderm;Enhancers;epigenomics;Equation;Event;Gene Expression;gene network;gene regulatory network;Genes;Genetic;Genetic Variation;genome wide association study;genomic locus;genomic variation;Genomics;Human Development;human disease;improved;in vivo;Individual;innovation;Kinetics;knock-down;Learning;Location;Machine Learning;machine learning model;Maps;Measurement;Methods;model building;Modeling;network models;novel;Phenotype;promoter;Property;Quantitative Trait Loci;Regulatory Element;Reporter;Reporting;Resolution;response;simulation;single-cell RNA sequencing;SOX17 gene;stem cell differentiation;Stimulus;Structure;System;temporal measurement;Testing;Time;time use;Tissues;Training;training data;transcription factor;transcriptome sequencing;Variant;Work;XCL1 gene

PROJECT_TITLE: Sequence-based Machine Learning for Inference of Dynamic Cell State Gene Network Models

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: DURHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative More than 16 million older Americans undergo anesthesia and surgery each year. Up to 40% of these patients develop postoperative delirium, a syndrome of waxing and waning changes in levels of alertness and attention, and which is associated with long term cognitive decline and an increased risk of developing Alzheimer’s disease. In this project, we seek to better understand how early Alzheimer’s disease-type changes predispose patients to show abnormal responses to anesthetic drugs, and the relationship between abnormal brain responses to anesthetic drugs and the risk of postoperative delirium.

PI_NAMEs: BERGER, MILES ;DEVINNEY, MICHAEL JOSEPH (contact)

PROJECT_TERMS: Age;aging brain;alertness;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Amyloid beta-Protein;Anesthesia procedures;Anesthetics;Attention;beta amyloid pathology;Biological Markers;Brain;brain abnormalities;brain dysfunction;Brain imaging;Brain Pathology;Brain region;Caring;Cerebrospinal Fluid;Clinical;Cognitive;cognitive testing;Data;Delirium;Dementia;Deposition;Development;Disease;dosage;Dose;Electroencephalography;Exercise;follow-up;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;human old age (65+);Image;Impaired cognition;inattention;Incidence;indexing;Intervention;Link;Magnetic Resonance Imaging;Measures;medial temporal lobe;Memory;Memory impairment;Monitor;Myocardial dysfunction;Neurocognitive;neurocognitive disorder;neuroimaging;neuropathology;neurophysiology;neurovascular;neurovascular injury;observational cohort study;older adult;older patient;Operating Rooms;Operative Surgical Procedures;Outcome;Parietal;Pathology;Patients;Pattern;Perioperative;pharmacologic;Phase;postoperative delirium;pre-clinical;prevent;prodromal Alzheimer's disease;prospective;Proteins;Psyche structure;Resistance;response;Rest;Risk;screening;Severities;Signal Transduction;skills;Spinal Puncture;standard of care;Stress Tests;stressor;Structure;Surgeon;Symptoms;Syndrome;tau Proteins;tau-1;Thalamic structure;Thallium Myocardial Perfusion Imaging Stress Test;Thinking;Thoracic Surgical Procedures;Time;Vascular Dementia;Waxes;White Matter Hyperintensity;Work

PROJECT_TITLE: Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and Inattention

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Depression;Genetics;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Major depression is a debilitating disorder affecting millions of people worldwide with limited success in treatment or remission. Despite a wealth of neurobiological studies over the last few decades, our understanding of the cellular and molecular processes associated with major depression is rudimentary, precluding the development of effective treatments. In this application, we are proposing an innovative line of research to examine the unique ability of mature microRNAs to translocate into nucleus with the help of exclusive nuclear signals and to determine their transcriptional and posttranscriptional roles in regulating their own expression and the expression of nuclear coding and non-coding genes that can be used as novel ‘‘molecular tools’’ to understand the etiopathogenesis of depressive behavior with a high potential to generate new molecular-based therapies to treat this severe mental disorder.

PI_NAMEs: DWIVEDI, YOGESH  (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: 3' Untranslated Regions;Affect;Agreement;Area;Aryl Hydrocarbon Receptor;Back;Binding;Binding Sites;Biotin;Brain;Brain Diseases;Cell model;Cell Nucleus;Chromatin;chromatin immunoprecipitation;chromatin isolation by RNA purification sequencing;Code;Complex;crosslink;crosslinking and immunoprecipitation sequencing;Cytoplasm;Data;depressive behavior;Development;Disease;Disease remission;effective therapy;Elements;endonuclease;Enzymes;Epigenetic Process;Etiology;exportin 1 protein;Exportins;Functional disorder;gene environment interaction;Gene Expression;gene function;Genes;Genetic Transcription;Genome Mappings;genome-wide;Glucocorticoid Receptor;Hippocampus;Importins;In Vitro;Individual;innovation;interest;Label;Major Depressive Disorder;Maps;Mediating;Messenger RNA;Microprocessor;MicroRNAs;miRNA expression profiling;Molecular;mRNA Expression;Neural Pathways;Neurobiology;new therapeutic target;novel;Nuclear;Nuclear Localization Signal;Nuclear Translocation;Oligonucleotides;overexpression;Pathogenesis;Pathway Analysis;Pattern;Persons;posttranscriptional;Prefrontal Cortex;Process;promoter;Promoter Regions;Proteins;Regulation;Regulator Genes;Research;Research Personnel;Ribonuclease III;Ribonucleoproteins;Ribonucleosides;RNA;RNA Interference;RNA purification;RNA-Induced Silencing Complex;Role;Sampling;Series;severe mental illness;Signal Transduction;success;Therapeutic Intervention;Tissues;tool;Transcript;Transcriptional Regulation;transcriptome;transcriptome sequencing;Untranslated RNA

PROJECT_TITLE: Novel regulatory role of nuclear miRNAs in repatterning the transcriptional and post-transcriptional dynamics in MDD brain

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Pediatric;Precision Medicine;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: PROJECT NARRATIVE Pediatric Crohn's Disease (CD) patient populations with severe disease subtypes suffer a loss of structural integrity of the small bowel and/or are non-responsive to treatment, which can negatively impact growth and development in these children. Identification of biomarkers aside from genomics, such as metabolic shifts which may occur in the bowel prior to development of severe disease, hold the power to separate at-risk pediatric populations and help physicians intervene earlier with personalized treatment. In this proposal, we will use a novel computational approach to characterize shifts in metabolism that occur across pediatric CD subtypes leveraging existing data archives with validation within a large, diverse cohort of over 400 patients.

PI_NAMEs: SYED, SANA  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Adverse effects;adverse outcome;Affect;Amino Acids;Anti-Inflammatory Agents;Antibiotics;archived data;Ascorbic Acid;Atlases;Autoimmune Diseases;Bacteria;biobank;Biochemical Pathway;Biological Markers;Biological Models;biomarker identification;Biopsy;cancer cell;Child;Childhood;Chronic;Clinical;clinical biomarkers;cofactor;cohort;computerized tools;Computing Methodologies;Crohn's disease;Crohn's disease of the ileum;Data;data archive;Data Set;Dependence;Development;Diagnosis;Disease;Disease Marker;Disease Outcome;disease phenotype;disorder subtype;Enzymes;Equilibrium;experimental study;fatty acid oxidation;Fistula;Future;Genetic Transcription;genomic biomarker;Genomics;Goals;Growth;Growth and Development function;Human;human tissue;ileum;in silico;in vivo;Inflammation;Inflammatory;innovation;Intervention;Intestines;Kinetics;Length;Link;lipidomics;Lipids;Literature;Manuals;Maps;Mass Chromatography;Mass Spectrum Analysis;mathematical model;Mathematics;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolic Pathway;Metabolism;metabolomics;Methods;mevalonate;Modeling;Normal tissue morphology;novel;nutrition;Organoids;Outcome;Pathology;Pathway interactions;patient population;patient stratification;patient subsets;Patients;Pediatric Crohn's disease;pediatric patients;Penetration;personalized medicine;Phenotype;Physicians;Plasma;Population;population based;prevent;Progressive Disease;prospective;Prospective cohort;Proteins;Proteomics;Proxy;Reaction;reconstruction;recruit;Resources;response;Risk;risk stratification;RNA;Sampling;Severity of illness;Site;Small Intestines;small molecule;success;Sulfur Metabolism Pathway;Surveys;Testing;Tissues;TNF gene;Transcript;transcriptome sequencing;transcriptomics;treatment response;Tricarboxylic Acids;Universities;Uridine;Validation;Virginia;Work

PROJECT_TITLE: Population-Based Characterization of Metabolic Pathways to Predict Pediatric Crohn's Disease Outcomes

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Data Science;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LOWELL

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

PHR: Narrative This project will develop an artificial intelligence (AI)-based approach to freeze the beating heart in CT images within a 60-millisecond time window (1/20 of a heart beat), eliminate the motion blurring of coronary arteries in these images, and facilitate analysis of plaque buildup in these arteries, which is the main cause of heart attacks. Our methods will not require patients to hold their breath during the CT exam, and eliminate the need to use beta-blocker drugs to slow patients’ heart rates. Our AI-empowered computational framework will offer major benefits to patients who have the high and irregular heart rates that commonly occur in older adults many of whom experience atrial fibrillation, and also greatly improve image quality of legacy CT scanners.

PI_NAMEs: YU, HENGYONG  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: 3-Dimensional;Academic Medical Centers;Acceleration;Address;Adrenergic beta-Antagonists;Adult;Algorithms;Aorta;Area;Arrhythmia;Arteries;Artificial Intelligence;Atrial Fibrillation;Breathing;Cardiac;Cardiovascular Diseases;Cessation of life;Clinical;clinical application;Clinical Research;clinically relevant;Compensation;computer framework;Computer software;contrast enhanced computed tomography;Coronary Angiography;Coronary artery;coronary computed tomography angiography;Data;Data Set;Dedications;deep learning;design;detector;Development;Diagnosis;diagnostic value;Dimensions;driving force;Electrocardiogram;empowerment;Evaluation;Exhibits;experience;experimental study;Freezing;frontier;generative adversarial network;Goals;Guidelines;Healthcare;Heart;heart imaging;heart motion;Heart Rate;Human;Hybrids;Image;image reconstruction;imaging approach;improved;Incidence;Individual;Knowledge;large datasets;learning network;Left;Location;Maps;Medical;Methods;millisecond;Modality;Modeling;Modernization;Morbidity - disease rate;Morphologic artifacts;mortality;Motion;Myocardial Infarction;next generation;older adult;open source;Organ;Pathology;Patients;Performance;performance tests;Pharmaceutical Preparations;Phase;Physiology;Positron-Emission Tomography;practical application;Prevalence;Qualitative Methods;Radiation exposure;Radon;Recommendation;reconstruction;Resolution;Rotation;Running;Scanning;Severities;signal processing;simulation;single photon emission computed tomography;Source;Stenosis;Structure;success;System;Tachycardia;Technology;temporal measurement;Time;tomography;tool;Training;Ventricular;X-Ray Computed Tomography

PROJECT_TITLE: AI-based Cardiac CT

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Immune checkpoint blockade (ICB) produces extraordinary clinical responses in more than 25 types of tumor, but only a small number of patients benefit from this therapy. Our data support a provocative model that G Pro- tein-Coupled Receptor 84 (GPR84) pathway can be pharmacologically activated to shape macrophages to- ward the anti-tumorigenic phenotype to overcome ICB therapy resistance. Results will inform the development of promising treatments to reshape immunosuppressive tumor microenvironment through manipulation of met- abolic signaling, and thereby restore responsiveness to PD-1 blockade for bladder cancer patients.

PI_NAMEs: XIN, GANG  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Ablation;Address;Affect;Agonist;anti-PD-1;arginase;Biochemical;Bladder Neoplasm;Cancer Model;Cancer Patient;CCAAT-Enhancer-Binding Protein-beta;Cells;Chromatin;Clinical;Coupled;Cyclic AMP;Data;Data Set;design;Development;effective therapy;efficacy evaluation;Epigenetic Process;Exhibits;Family;fatty acid oxidation;Fatty Acids;Flow Cytometry;Fostering;Foundations;G-Protein-Coupled Receptors;Genetic;Genetic Transcription;genome-wide;Goals;GPR84 gene;GTP-Binding Proteins;high dimensionality;Human;immune checkpoint blockade;immune function;Immune response;Immunity;Immunologic Stimulation;immunoregulation;immunosuppressive macrophages;Immunotherapy;insight;Knowledge;loss of function;Macrophage;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Mediating;member;Metabolic;Metabolism;Methods;Modeling;Molecular;Monoclonal Antibody Therapy;mouse model;Mus;Myelogenous;Myeloid Cells;NF-kappa B;Nonesterified Fatty Acids;novel therapeutic intervention;Pathway interactions;Patients;PD-1 blockade;pharmacologic;Phenotype;precision medicine;prevent;Process;Production;programs;Publishing;receptor;Resistance;response;Role;sensor;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;signature molecule;T cell response;T-Lymphocyte;Therapeutic;therapeutic target;TNF gene;transcription factor;transcriptome;tumor;Tumor Escape;tumor growth;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;tumorigenic;Work

PROJECT_TITLE: Targeting GPR84 to Overcome Macrophage Mediated Resistance to Immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Mental Health;Neurosciences

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on developing new technologies to understand the molecular mechanism underlying causes of mental diseases. This study will yield a wireless neural probe to sample multiple neuropeptides and to conduct pharmacological stimulation during freely moving behaviors of animals, which will allow for rapid interrogations of neural circuits.

PI_NAMEs: ZHANG, YI  (contact)

PROGRAM_OFFICER_NAME: ALVAREZ, RUBEN PAUL

PROJECT_TERMS: absorption;Affect;Animal Behavior;Animals;Anxiety;awake;Behavior;Behavioral;behavioral study;Benchmarking;Biosensor;Blood capillaries;Brain;carbon fiber;Cell Membrane Permeability;cell type;Chemicals;Collection;Color;Communities;Computer software;design;Detection;Development;Device Designs;Devices;Diffusion;Disease;Enzyme-Linked Immunosorbent Assay;Functional disorder;gamma-Aminobutyric Acid;Genetic;Goals;Human;in vivo;innovation;interest;Knowledge;Lateral Hypothalamic Area;light weight;Link;Liquid Chromatography;liquid chromatography mass spectrometry;Liquid substance;Measurement;Membrane;Mental Depression;Mental disorders;Methods;Microdialysis;microsystems;miniaturize;Modeling;Molecular;Molecular Weight;Monitor;multidisciplinary;multimodality;Mus;nano;neural;neural circuit;neurochemistry;Neurons;Neuropeptides;Neuropharmacology;neuroregulation;Neurosciences;neurotechnology;new technology;operation;Outcome;Output;Oxidation-Reduction;Periodicity;Persons;pharmacologic;Play;polypeptide;Power Sources;prevent;Process;Proteins;prototype;Psyche structure;Public Health;Quality of life;Rattus;Research;Resolution;Role;Sampling;Scanning;sensor;sensor technology;Silicon Dioxide;small molecule;spatiotemporal;specific biomarkers;Specificity;Stress;System;tandem mass spectrometry;Technology;technology validation;Time;tool;Tube;wireless;wireless electronic;wireless implant;Work

PROJECT_TITLE: A Wireless, Multimodal Neural Probe for Simultaneous Membrane-Free Neurochemical Sampling and Neuropharmacology

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Rare Diseases

ORG_DEPT: OTHER BASIC SCIENCES

PHR: PROJECT NARRATIVE Malformation of cerebellar structures during development is a hallmark of rare neurological ciliopathies like Joubert Syndrome and related disorders. Here, I propose to investigate a novel role for formin family actin polymerizer, FMNL2 as a regulator of microtubule dynamics, which upon disruption leads to ciliopathy-like phenotypes in mice. This proposal will investigate the role of FMNL2 in cerebellar development and provide novel insight into the mechanisms behind actin and microtubule interactions in ciliary signaling.

PI_NAMEs: TRAN, JOYCE  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: 3' Splice Site;Actins;Affect;Alleles;Anterior;Ataxia;Axon;base;Behavior;Binding;Brain;brain abnormalities;Brain Diseases;Brain region;cancer cell;Candidate Disease Gene;Cell surface;cell type;Cells;Cerebellar Diseases;Cerebellar malformation;Cerebellar vermis structure;Cerebellum;Chemicals;Cilia;ciliopathy;cilium biogenesis;Cilium Microtubule;Cognitive deficits;Complement;conditional knockout;Critical Pathways;Cultured Cells;Cytoskeleton;Data;Defect;Development;Developmental Delay Disorders;Disease;exon skipping;Exons;experimental study;Failure;Family;Filopodia;FMNL2 gene;forward genetics;Fossa;Functional disorder;functional status;Genes;genetic approach;granule cell;Hippocampus;Human;Human Development;human disease;in vivo;Induced Mutation;insight;Investigation;Joubert syndrome;Kidney;kinetosome;Knockout Mice;Laboratory Finding;Length;Link;Liver;Maintenance;malformation;Medial;Microtubule Stabilization;Microtubules;migration;Molecular;Morphology;Motor;mouse model;Mus;Mutagenesis;mutant;Mutant Strains Mice;Mutation;Nerve Degeneration;nerve stem cell;Nervous System;Neurodevelopmental Disorder;Neurologic;Neurons;novel;Optics;Patients;Phenotype;Play;Point Mutation;polymerization;Polymers;positional cloning;Proliferating;Protein Family;protein function;Proteins;rare genetic disorder;Regulation;RNA Splicing;Role;scaffold;screening;Sequence Analysis;SHH gene;Signal Transduction;Signaling Protein;Skeletal system;social deficits;Structure;System;trafficking;Transcript

PROJECT_TITLE: Investigation of fmnl2 in cerebellar development


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Prevention;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Liver fibrosis is a potentially life-threatening complication associated with several chronic liver diseases, thereby representing a high medical and economic burden. Proposed study aims to unravel the role of FGFR signaling in liver injury and fibrosis

PI_NAMEs: MAVILA, NIRMALA  (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Adult;Affect;Area;Biliary;Biliary Atresia;Biology;cell type;Cells;Characteristics;Child;chronic liver disease;chronic liver injury;Cirrhosis;Complication;Data;Disease;dosage;Early identification;Early Intervention;Economic Burden;end stage liver disease;Epithelial Cells;Epithelium;Event;Experimental Models;FGF2 gene;FGFR1 gene;Fibroblast Growth Factor;Fibroblast Growth Factor Receptor 1;Fibroblast Growth Factor Receptors;Fibrosis;Focal Adhesion Kinase 1;Genetic;Genomics;Goals;GPC3 gene;growth factor receptor-bound protein 2;heparin proteoglycan;Hepatic;Hepatic Stellate Cell;Homeostasis;Human;in vivo Model;Infant;Infection;Injury;Integral Membrane Protein;intrahepatic;Life;Ligands;Literature;Liver;liver development;Liver Failure;Liver Fibrosis;liver injury;Mediating;Medical;Membrane;Metabolic;Modeling;Molecular;mortality;mouse model;Nature;new therapeutic target;novel;novel strategies;Organoids;Pathway interactions;Population;Population Heterogeneity;prevent;Prevention;Primary biliary cirrhosis;primary sclerosing cholangitis;progenitor;prominin;Proteomics;Publishing;Reaction;receptor;Receptor Activation;receptor binding;Receptor Signaling;receptor-mediated signaling;Research;Role;Scientific Advances and Accomplishments;Signal Pathway;Signal Transduction;Testing;therapeutic target;Toxin;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Transforming Growth Factors;Work

PROJECT_TITLE: FGFR Signaling in Liver Injury and Fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(03)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE- OVERALL The Alzheimer's Disease Research Center (ADRC) at New York University Langone Health has facilitated pioneering research to define transitions from normal aging to the subjective cognitive decline (SCD), mild cognitive impairment (MCI), and early dementia stages of AD; as well as AD biomarker development. We now propose to continue this long-standing successful research direction with a focus on understanding disease heterogeneity and delineating biomarkers and their role in these transitions, with the long-term goal of helping to develop novel interventions that will delay or prevent cognitive decline, to help achieve the NAPA goal of a cure by 2025.

PI_NAMEs: WISNIEWSKI, THOMAS M (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Acceleration;aged;aging brain;Alzheimer's Disease;Amyloid;Area;Autopsy;Behavioral;Biological Assay;Biological Markers;biomarker development;biomarker identification;Cerebrospinal Fluid;Clinical;Clinical Data;clinical training;Cognitive;cognitive function;cognitive testing;Collaborations;Communities;community setting;Counseling;Cyclotrons;Data Linkages;data management;Data Set;Dementia;Development;Diagnosis;Diagnostic Services;disease heterogeneity;Early Diagnosis;Education;education research;epidemiology study;Fostering;Funding;Goals;Health;Heterogeneity;Impaired cognition;improved;in vivo;induced pluripotent stem cell;Infrastructure;innovation;Intervention;Investigation;Laboratories;Magnetic Resonance Imaging;Measures;Mental Depression;Methodology;mild cognitive impairment;Mission;neuroimaging;neuropathology;Neuropsychology;New York;next generation;normal aging;novel;novel marker;novel therapeutic intervention;outreach;Participant;Pathology;Patients;Performance;Phenotype;Plasma;Population;Positron-Emission Tomography;posters;prevent;programs;Proteomics;Psychological Impact;psychosocial;Radiochemistry;recruit;Research;Role;Scanning;Scientist;Secure;Serum;social factors;sociodemographic variables;Statistical Data Interpretation;Stress;tau Proteins;Techniques;Therapeutic Intervention;therapeutically effective;Time;Training;Training and Education;Translational Research;Universities;Update;Work

PROJECT_TITLE: Alzheimer's Disease Research Center


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative This project focuses on the mechanisms of immune evasion in triple-negative breast cancer (TNBC), with a particular focus on the integrin αVβ6 – SOX4 pathway. We will therapeutically target this pathway with an antibody targeting integrin αVβ6 and investigate the mechanisms by which this pathway inhibits T cell-mediated tumor immunity. The clinical relevance of this pathway will be investigated by multi-color immunofluorescence analysis of human triple-negative breast cancers.

PI_NAMEs: WUCHERPFENNIG, KAI W (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Affinity;Antibodies;Biology;biomarker identification;Blood Circulation;Blood Vessels;Breast Cancer Cell;Breast Cancer Model;cancer immunotherapy;Carcinoma;CD8-Positive T-Lymphocytes;Cell Density;cell type;Cells;Cellular Immunity;Clinical Trials;Clinical Trials Design;clinically relevant;Color;Complex;CRISPR screen;cytokine;Cytotoxic T-Lymphocytes;Data;Disease;Double-Stranded RNA;ds-DNA;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Exposure to;Fibrosis;Future;gene discovery;Gene Expression;Genetic Transcription;genome-wide;Goals;Human;Immune;immune checkpoint blockade;Immune Evasion;immune resistance;Immunofluorescence Immunologic;Immunotherapy;Implant;Infiltration;inhibitor;innate immune pathways;Integrin alphaV;integrin beta6;Integrin Inhibition;Integrins;Interferons;lymph nodes;Malignant Neoplasms;Mediating;migration;Modeling;Molecular;Monoclonal Antibodies;mouse model;Mus;Mutation;Neoplasm Metastasis;neoplastic cell;Pathway interactions;Patient Selection;patient subsets;Patients;Population;Primary Neoplasm;programs;Proteins;refractory cancer;Resistance;resistance mechanism;response;Role;small molecule inhibitor;SOX4 gene;spatial relationship;Specimen;Stimulator of Interferon Genes;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Tissues;TP53 gene;transcription factor;Transforming Growth Factor beta;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor-immune system interactions

PROJECT_TITLE: Targeting of a Major Immune Evasion Pathway in Triple-negative Breast Cancer

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

PROJECT_TERMS: Acceleration;Administrator;Advisory Committees;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Welfare;Biological Markers;biomarker identification;Clinical;Cognitive;Collaborations;Communication;Communities;Consultations;Data;data management;Data Set;Dementia;Development;education research;Ensure;Faculty Recruitment;Financial Support;Fostering;Future;Grant;Health;Heterogeneity;human subject;Impaired cognition;Institution;Intervention;Leadership;meetings;mild cognitive impairment;Mission;Monitor;neural;neuroimaging;Neurology;neuropathology;Neurosciences;next generation;normal aging;novel;outreach;Play;Policies;posters;prevent;Procedures;Process;Productivity;programs;psychosocial;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Role;Sampling;Science;Scientist;symposium;Technology;transmission process;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative One major reason for the current obesity epidemic and its associated lack of effective treatment is due to incomplete understanding of neuronal control of body weight. Using a combination of viral tracing and intersectional mouse genetics, the current proposal aims to dissect the role of distinct AgRP neuron projections that mediate the massive obesity development produced by chronic AgRP neuron activation. The results will identify brain circuit mechanisms for obesity and therefore form a foundation for effective treatments against obesity.

PI_NAMEs: TONG, QINGCHUN  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Acute;Address;Adult;Animal Model;Area;ART protein;Bacteria;Body Weight;Brain;Chronic;Cues;design;Development;Diet;effective therapy;Energy Metabolism;Exhibits;feeding;Feeding behaviors;Foundations;Functional disorder;gamma-Aminobutyric Acid;Goals;hindbrain;Homeostasis;Hypothalamic structure;Individual;Investigation;Knowledge;Lateral Hypothalamic Area;Leptin;Leptin deficiency;leptin receptor;Mediating;Mediator;midbrain central gray substance;Modeling;mouse genetics;mouse model;Mus;Neonatal;neonate;Neural Pathways;Neurons;neuropeptide Y;neurotransmitter release;Neurotransmitters;Nutritive Value;Obese Mice;Obesity;obesity development;Obesity Epidemic;overexpression;parabrachial nucleus;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Play;Pro-Opiomelanocortin;receptor expression;Regulation;Research;Rodent;Role;segregation;side effect;Site;Sodium Channel;Structure of terminal stria nuclei of preoptic region;Subgroup;Thalamic structure;Therapeutic;therapeutic development;Viral

PROJECT_TITLE: Neural pathways for obesity development by AgRP neurons

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: MASURKAR, ARJUN VIJAY (contact)

PROJECT_TERMS: Action Research;Address;African American;African American population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Biological Markers;Black Populations;Black race;Brain;career;Cerebrovascular Disorders;Clinical;Clinical Assessment Tool;Clinical assessments;clinical biomarkers;clinical phenotype;clinical risk;Clinical Skills;Clinical Trials;Cognition;Cognitive;Cognitive aging;cognitive change;cohort;Collaborations;Communities;Consent;Data;data management;Data Reporting;Dementia;Detection;Diagnosis;Diagnostic;Digital biomarker;Disease;disease heterogeneity;early detection biomarkers;education research;Emerging Technologies;Etiology;Evaluation;experience;genetic risk factor;global deterioration scale;Goals;Health Professional;Heterogeneity;imaging biomarker;Impaired cognition;improved;innovation;Intervention;Intervention Studies;Latino Population;Life Style;Longitudinal Studies;Measures;Monitor;Motor;Nerve Degeneration;neuroimaging;neuropathology;neuropsychiatric symptom;next generation;normal aging;Normal Range;novel;older adult;outreach;Participant;Pathologic;Pathology;patient engagement;Patient Recruitments;Populations at Risk;Positron-Emission Tomography;pre-clinical;prevent;Probability;programs;Protocols documentation;Psychometrics;psychosocial;recruit;Registries;repository;Research;Research Personnel;Resources;Risk;Role;Scheme;Scientist;Screening procedure;Site;skills;Sleep;statistics;tau Proteins;Technology;Testing;tool;Training;Underrepresented Populations;Work

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Immunization;Immunotherapy;Orphan Drug;Rare Diseases;Vaccine Related

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE: Head and neck cancer is one of the major causes of cancer related death in the US and worldwide and exhibits a high degree of interpersonal and intratumoral heterogeneity, making it difficult to treat. Our grant application proposes to develop a novel personalized immunotherapy approach using membrane vesicles prepared from patients’ own surgically excised tumor tissue, modifying them by protein transfer to express immunostimulatory molecules and administering them to patients along with immune checkpoint inhibitor to boost the immune response against cancer cells. The proposed approach does not require establishment of cell lines, identification of tumor antigens or in vitro manipulation of immune cells, thus making it applicable to wide number of patients in a cost-effective manner.

PI_NAMEs: SELVARAJ, PERIASAMY ;SHIN, DONG M (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Address;Adjuvant;Adult;Animal Model;anti-PD-1;anti-PD1 antibodies;anti-tumor immune response;Antigen Targeting;antigen-specific T cells;Antigens;Antitumor Response;Applications Grants;Autologous;Biological;Blood;cancer cell;Cancer Etiology;Cancer Model;Cancer Vaccines;Carbohydrates;Cells;Cessation of life;checkpoint therapy;Clinical;Clinical Trials;Clinical Trials Design;clinically relevant;cohort;cost effective;Data;Dependence;Dose;dose information;Epitopes;established cell line;exhaustion;Exhibits;Gene Mutation;Gene Targeting;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Heterogeneity;Human;Immune;Immune checkpoint inhibitor;Immune response;Immunity;Immunologic Markers;Immunologic Stimulation;Immunotherapy;improved;In Vitro;Lead;Link;Logistics;Major Histocompatibility Complex;malignant mouth neoplasm;Malignant Neoplasms;Membrane;Metastatic Squamous Cell Carcinoma;Monoclonal Antibodies;mouse model;Mus;Nature;Neoplasm Metastasis;novel;novel vaccines;Operative Surgical Procedures;Particulate;Pathway interactions;patient variability;Patients;pembrolizumab;Peptides;personalized immunotherapy;Pharmaceutical Preparations;Phase;Phase Ib Clinical Trial;Play;prevent;primary endpoint;programmed cell death protein 1;Progression-Free Survivals;Proteins;Recommendation;Recurrence;Reporting;Resistance;response;Role;Safety;scaffold;Schedule;secondary endpoint;small molecule;Source;synergism;T cell infiltration;T cell response;T-Lymphocyte;Testing;therapeutic vaccine;therapeutically effective;Translating;tumor;Tumor Antigens;Tumor Cell Derivative Vaccine;Tumor Expansion;tumor growth;tumor heterogeneity;Tumor Immunity;Tumor Tissue;Vaccination;vaccine development;vaccine immunogenicity;vaccine immunotherapy;vaccine trial;Vaccines;Vesicle;Weight;Whole Cell Vaccine;Work

PROJECT_TITLE: Personalized vaccine immunotherapy in combination with anti-PD 1 antibody for recurrent or metastatic squamous cell carcinoma of the head and neck

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Data Science;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: SHAO, YONGZHAO  (contact)

PROJECT_TERMS: Address;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;analytical method;Applications Grants;Basic Science;Biological Markers;Brain;Charge;Clinical;Clinical Trials;Clinical Trials Design;cohort;Collaborations;Communities;computational platform;Computer software;Consultations;Data;data acquisition;Data Analyses;Data Analytics;data exchange;data management;Data Set;data sharing;Data Storage and Retrieval;data visualization;data warehouse;Databases;design;Development;disease heterogeneity;electronic data;Ensure;Evaluation;Genetic;Genomics;Heterogeneity;Impaired cognition;Individual;Informatics;Information Management;innovation;insight;Intervention;machine learning method;Maintenance;Measures;Mentors;Methods;Multicenter Studies;multidimensional data;neuroimaging;novel;open source;Participant;Pilot Projects;Population Research;Process;Proteomics;psychosocial;Randomized;Registries;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Resolution;Resources;risk prediction model;Secure;Services;skills;social media;Source;Specimen;Standardization;Statistical Data Interpretation;Statistical Methods;Statistical Models;statistics;Sum;synergism;System;Technology;tool;Training;Training Programs;translational impact;translational pipeline;Translational Research;transmission process;Visualization;Visualization software;web site

PROJECT_TITLE: Data Management and Statistical Core


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

PHR: As the population ages, more and more patients are cared for in intensive care units. However, there is a growing gap between the rapidly expanding need for critical care services and both the workforce needed to take care of critically ill patients and the researchers needed to discover new insights to improve outcomes in the intensive care unit. This institutional training grant is aimed at bridging this gap by providing research training for individuals who will pursue careers related to critical care.

PI_NAMEs: COOPERSMITH, CRAIG M (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: Critical Care;Training Programs

PROJECT_TITLE: Critical Care Training Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Acceleration;Address;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Model;Autopsy;Biological Markers;Blood Vessels;Brain;brain tissue;Cell Line;Cell model;Clinical;Collaborations;Collection;Communities;Data;Dementia;Diagnosis;Diagnostic;disease heterogeneity;Education and Outreach;Enrollment;Evaluation;Family;Health Professional;Heterogeneity;Image;Impaired cognition;induced pluripotent stem cell;innovation;International;Intervention;laboratory facility;Measures;Methods;mild cognitive impairment;Molecular;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;neuropathology;new therapeutic target;next generation;normal aging;novel;novel diagnostics;novel therapeutic intervention;Participant;Pathogenesis;Pathology;Patients;prevent;Procedures;programs;Property;Proteomics;Protocols documentation;psychosocial;Reporting;repository;Research;research clinical testing;Research Personnel;Resources;Risk;Sampling;Source;Standardization;Syndrome;System;Technology;Therapeutic;therapeutically effective;tissue processing;Tissue Sample;Tissues;Training;Work

PROJECT_TITLE: Neuropathology Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: NEUROSCIENCES

PHR: Narrative Increasing evidence suggests that astrocytes play a critical role in regulating synaptic plasticity and circuit remodeling, but their role in addiction-related cellular and behavioral adaptations remains underexplored. The current application aims to understand astrocyte-mediated remodeling of cocaine-generated synapses and neuronal populations that drive cocaine seeking. The expected results will provide new insights into novel mechanisms underlying drug addiction.

PI_NAMEs: DONG, YAN  (contact);NESTLER, ERIC J.

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Address;Adult;AMPA Receptors;Animal Model;Applications Grants;Astrocytes;Behavioral;Brain;cell type;Cocaine;cocaine exposure;cocaine relapse;cocaine seeking;cocaine self-administration;Cocaine withdrawal;Cues;Drug Addiction;drug withdrawal;Electrophysiology (science);Ensure;Exhibits;experience;experimental study;Filopodia;Funding;Generations;Glutamates;Image;in vivo;in vivo imaging;insight;Measures;Mediating;Memory;memory retrieval;Molecular;Monitor;Mus;neural circuit;Neurobiology;Neurons;Newborn Infant;novel;Nucleus Accumbens;Outcome;Pharmaceutical Preparations;Play;Population;Prevention;Process;Property;recruit;response;Retrieval;Rodent;Role;Signal Transduction;Slice;success;Synapses;Synaptic plasticity;synaptogenesis;targeted treatment;Testing;Therapeutic;Thinness;tool;Training;transcriptome sequencing;two photon microscopy;Up-Regulation;Withdrawal;Work

PROJECT_TITLE: Glial-mediated synaptic remodeling in drug addiction


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: CHODOSH, JOSHUA  (contact)

PROJECT_TERMS: African American;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease related dementia;animation;Attention;Biological Markers;biomedical referral center;Black race;Clinical;clinical center;Clinical Services;Clinical Trials;cohort;Collaborations;Communication;Communities;community advisory board;community collaboration;Community Health Aides;community organizations;Community Services;Confidentiality of Patient Information;Data;Detection;Disease;disease heterogeneity;Disease Progression;Education;education research;Educational workshop;effective therapy;Effectiveness;Electronic Health Record;electronic health record system;Ensure;Evaluation;Event;experience;Face;Feedback;Funding;Funding Opportunities;Goals;Growth;Health Fairs;human subject;improved;Incidence;innovation;Institution;interest;Investigation;Laboratories;Latino;Learning;Link;meetings;member;Mission;National Institute on Aging;neighborhood disadvantage;neuropathology;New York;novel;outreach;Participant;Patients;peer;Play;Population;population based;Population Heterogeneity;Positioning Attribute;Prevalence;prevent;Program Development;programs;psychosocial;Psychosocial Assessment and Care;recruit;Recruitment Activity;Registries;Research;Research Activity;research and development;research study;Research Subject Recruitments;Research Subjects;Resources;response;Role;Services;Social Work;Students;Technology;Therapeutic Trials;Training;underserved community;United States National Institutes of Health;Universities;Workforce Development

PROJECT_TITLE: Outreach, Recruitment and Engagement Core


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Interstitial Cystitis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation;Urologic Diseases

ORG_CITY: STANFORD

ORG_DEPT: UROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE  This proposal is relevant to public health in the way in which it designed to, in the long-term, potentially improve the way in which urinary diversion surgery is done. If we are successful in generating autologous bladder urothelial stem cells, we will expand the opportunities for cell-based therapy approaches to disorders of the urothelium, such as radiation cystitis or interstitial cystitis, and improve upon the engineering of bladder or urothelial substitutes that can be potentially used in patients with severe hemorrhagic cystitis, end-stage painful bladder syndrome, urinary tract trauma, or congenital urinary tract abnormalities.

PI_NAMEs: PRADO, KRIS  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Ablation;Anatomy;Area;ATAC-seq;Autologous;Binding;Biological Assay;Bladder;Bladder Control;Bladder Injury;Bladder Urothelial Cell;Bladder Urothelium;Bypass;Cell Differentiation process;Cell Therapy;cell type;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Cyclophosphamide;Cystitis;Data;design;Development;differentiation protocol;Disease;Electrolytes;embryonic stem cell;Engineering;Epigenetic Process;Epithelium;Fibroblasts;functional outcomes;Future;Gastrointestinal tract structure;Genetic;Genitourinary system;Goals;Growth;Health;Hemorrhage;Human;Ileus;Immunocompromised Host;Immunosuppression;improved;in vivo;induced pluripotent stem cell;infection risk;Injury;Interstitial Cystitis;intestinal epithelium;Intestines;knock-down;Maps;Mesenchymal Stem Cells;Metabolic;Methods;Molecular;Morphology;mouse model;Mus;novel;Operative Surgical Procedures;Organoids;Outcome;overexpression;Patients;Perioperative;Play;postoperative recovery;Process;Protocols documentation;Public Health;radiation cystitis;reconstitution;reconstruction;Reconstructive Surgical Procedures;regenerative;Regenerative Medicine;Regulation;Reporter;Review Literature;Risk;screening;Screening Result;side effect;Small Intestines;Sorting;Source;stem cell differentiation;stem cell organoids;Stem cell transplant;stem cells;Surgical complication;Teratoma;Testing;Tissue Engineering;Tissues;transcription factor;transdifferentiation;Transplantation;Trauma;UPK2 gene;UPK3 gene;urinary;Urinary Diversion;Urinary system;Urinary tract;Urinary tract infection;urologic;Urologic Surgical Procedures;Urothelial Cell;urothelial injury;Urothelium;Work

PROJECT_TITLE: Direct conversion of fibroblasts to urothelial stem cells

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Microbiome;Neurodegenerative;Neurosciences;Prevention

PROJECT_TERMS: Address;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;apolipoprotein E-4;Basic Science;behavior measurement;Biological;Biological Assay;Biological Markers;Blood;Blood Vessels;Brain;Cerebrospinal Fluid;Cerebrovascular Disorders;Clinical;Clinical Research;clinically relevant;Cognitive;Collaborations;Communities;cost effective;Data;data management;Data Set;data sharing;Dedications;Dementia;design;Diagnosis;diagnostic tool;Disease;disease heterogeneity;Disease Progression;DNA;DNA Methylation;Enzyme-Linked Immunosorbent Assay;epidemiology study;Equipment;Fostering;Funding;Future;Genomics;glial activation;Goals;Heterogeneity;Human Resources;Impaired cognition;improved;Inflammation;Intake;Interdisciplinary Study;Intervention;Light;Link;Magnetic Resonance Imaging;metabolomics;microbiome;microbiome analysis;mild cognitive impairment;Nerve Degeneration;neurobiological mechanism;neurofilament;neuroimaging;neuropathology;next generation;normal aging;novel;novel marker;Participant;Pathology;Pathway interactions;phenotypic biomarker;Phosphorylation;Plasma;Positron-Emission Tomography;Postdoctoral Fellow;pre-clinical;predictive modeling;prevent;Procedures;Process;Prognosis;programs;Proteomics;Quality Control;Research;Research Personnel;Risk;RNA;Role;Sampling;Scientific Advances and Accomplishments;Serum;sex;Sleep;statistics;stool sample;Students;Systems Biology;tau Proteins;tau-1;Technology;Tissue Banks;tool;transcriptomics;Translational Research;Work

PROJECT_TITLE: Biomarker Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Glucocorticoid-induced ocular hypertension and glaucoma are the most common ocular complications of prolonged glucocorticoid use, which may lead to irreversible blindness. This project is relevant to public health because it focuses on how the distal aqueous humor outflow pathway tissues contribute to this disease. Therefore, the proposed research is relevant to the part of NEI’s mission that pertains to developing fundamental knowledge with respect to blinding eye diseases.

PI_NAMEs: MAO, WEIMING  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: 3D Print;Anterior;aqueous;Aqueous Humor;Area;Autoimmune Diseases;Bar Codes;Binding;Blindness;Cattle;Cell Nucleus;Cells;Clinical;Closure by clamp;Collagen;Complex;Cornea;cost;Data;Deposition;design;Dexamethasone;Disease;Distal;Ethanol;Excision;Extracellular Matrix;Extravasation;Eye;Eye diseases;Fibronectins;Gene Expression;Glaucoma;glaucoma surgery;Glucocorticoid Receptor;Glucocorticoids;Glues;Goals;Hematoxylin and Eosin Staining Method;Human;In Situ;In Situ Hybridization;Inflammatory;interest;Keratoplasty;Knowledge;Left;Medicine;Methods;minimally invasive;Mission;Modeling;Molecular;Mus;novel;novel strategies;Ocular Hypertension;ocular hypotensive;Oligonucleotides;Ophthalmologic Surgical Procedures;Pathway interactions;Patients;Perfusion;Phagocytes;Procedures;Protocols documentation;Public Health;Publishing;Reporting;Research;Resistance;Resolution;responders and non-responders;response;Retinal Ganglion Cells;RNA;Role;Sclera;Site;Slide;Spottings;Stains;Structure;Structure of sinus venosus of sclera;Technology;Thinness;tissue preparation;Tissues;Trabecular meshwork structure;transcriptome sequencing;Veins

PROJECT_TITLE: The role of distal aqueous humor outflow tissue in glucocorticoid-induced glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: RUSINEK, HENRY  (contact)

PROJECT_TERMS: abeta accumulation;abeta deposition;Aging;aging brain;Algorithms;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Anatomy;animal imaging;Animal Model;Archives;Atrophic;Autopsy;Award;Biological Markers;Blood Vessels;Brain;Brain imaging;Carbon Dioxide;cerebrospinal fluid clearance;cerebrovascular;Classification;Clinical;clinical imaging;clinically relevant;Collaborations;Computer software;Consultations;data management;Databases;deep learning;design;Development;Diagnosis;Diagnostic;Diffusion;Early Diagnosis;Early identification;entorhinal cortex;experience;Faculty;Funding;Future;Goals;hippocampal atrophy;Hippocampus;Human;Human Resources;Hydration status;Hydrogen;Image;Image Analysis;image guided;image reconstruction;imaging approach;Imaging Device;imaging modality;imaging study;Imaging technology;Impaired cognition;improved;in vivo;Iron;Kinetics;Lesion;Link;Machine Learning;machine learning model;Magnetic Resonance Imaging;Measures;medial temporal lobe;metabolic rate;Metabolism;Methods;Modeling;Molecular;Nerve Degeneration;neuroimaging;neuropathology;Pathogenesis;Pathologic;Perfusion;Positron-Emission Tomography;predictive modeling;Protocols documentation;Protons;Quality Control;Recommendation;reconstruction;Recovery;Reference Values;Research;Research Personnel;Research Project Grants;Resources;Risk Factors;Scientist;Sodium;Specimen;Standardization;tau Proteins;Techniques;Technology;Thick;Training;Translating;United States National Institutes of Health;uptake;Validation;water diffusion;white matter;Work

PROJECT_TITLE: Neuroimaging Core


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: PROJECT NARRATIVE The proposed project uses Reinforcer Pathology, an Experimental Medicine approach that identifies novel determinants of cocaine valuation at multiple levels of analysis (behavioral, neural, and computational), to mechanistically test a new conceptual framework for understanding cocaine use disorder. Existing treatments for cocaine use disorder are not optimally robust and are further limited by an incomplete understanding of the mechanisms of cocaine use disorder - a gap that this project aims to address. Results from these studies will positively impact public health because Reinforcer Pathology suggests innovative interventions that will decrease consumption and valuation of cocaine.

PI_NAMEs: LACONTE, STEPHEN M (contact)

PROGRAM_OFFICER_NAME: PARIYADATH, VANI

PROJECT_TERMS: addiction;Address;Anterior;Behavioral;biobehavior;Biological Models;Brain;Brain Mapping;Brain region;Bypass;Cocaine;cocaine use;Cocaine use disorder;computational neuroscience;Computer Models;Consumption;craving;Cues;Data;discounting;efficacious intervention;Event;experimental study;Exposure to;Foundations;Functional Magnetic Resonance Imaging;Future;Generations;Goals;Hippocampus;improved;Individual;innovation;insight;interest;Intervention;Laboratories;Lateral;Length;Maps;Measures;Mediating;Medicine;Methods;Modeling;multiple drug use;neural;neurobehavioral;Neurocognitive;neurofeedback;neuroimaging;novel;open innovation;Outcome Measure;Participant;Pathology;Patient Self-Report;Pattern;Pharmaceutical Preparations;predictive modeling;Prefrontal Cortex;Process;Public Health;Randomized;reinforcer;Research;Research Project Grants;Resistance;Role;sex;Specific qualifier value;Stress;System;Testing;theories;therapeutic target;therapy development;Thinking;Time;Translational Research;Urinalysis;Work

PROJECT_TITLE: An Experimental Medicine Approach for the Mechanistic Understanding of Cocaine Use Disorder: Reinforcer Pathology

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative Although costly and invasive, hydrostatic pressure measurements are required for the diagnosis and management of a wide variety of clinical diseases. An ultrasound contrast agent (UCA) based technique termed subharmonic aided pressure estimation (SHAPE) has shown promise in several clinical trials, but the sensitivity of the technique is currently limited due to polydisperse nature of commercial UCA. Thus, we propose to develop a monodisperse, clinically translatable, SHAPE-specific UCA to improve overall sensitivity and to reconcile theoretical modeling work with empirical data.

PI_NAMEs: EISENBREY, JOHN  (contact);SARKAR, KAUSIK

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Acoustics;Blood Vessels;Cardiac;Catheters;Clinical;clinical care;clinical translation;Clinical Trials;Computer software;Contrast Media;cost;Cost Measures;Custom;Data;Data Collection;Devices;Diagnosis;Disease;Equation;Estimation Techniques;Exhibits;fabrication;Frequencies;Gases;Goals;Heart;Hydrostatic Pressure;improved;In Vitro;in vitro testing;in vivo Model;individual response;interfacial;interstitial;Intracranial Pressure;intravenous injection;Lipids;Liquid substance;Measurement;Measures;meter;Microbubbles;Microfluidics;Modeling;Monitor;Nature;Needles;Parameter Estimation;Patients;Pharmacological Treatment;Population;Portal Hypertension;Portal Pressure;Portal vein structure;Pre-Clinical Model;pressure;Property;Reference Standards;Research;response;Rheology;Risk;Signal Transduction;success;Surface;Techniques;Testing;Theoretical model;Translating;transmission process;treatment response;tumor;ultrasound;Variant;Water;Work

PROJECT_TITLE: Monodisperse Microbubbles for Noninvasive Pressure Estimation

STUDY_SECTION: EITA


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Social Determinants of Health

PI_NAMEs: MITTELMAN, MARY SHERMAN (contact)

PROJECT_TERMS: Affect;age related;Aging;Alzheimer's Disease;Autopsy;Biological Markers;Brain;Brain imaging;caregiver interventions;Caregivers;Caring;Clinical;clinical training;Clinical Trials;Cognitive;cognitive change;cognitive function;cognitive testing;cohort;Collaborations;Communities;Consultations;coping;Counseling;daily functioning;Data;Data Analyses;Data Set;Databases;Dementia;depressive symptoms;design;Development;Disease;Disparity;doctoral student;Education;Emotional;Environment;Evaluation;Evidence based intervention;Family Caregiver;Family member;family support;Fostering;Goals;Health;health care service;Image;Image Analysis;Impaired cognition;Impairment;improved;Individual;innovation;insight;instrument;Intervention;intervention participants;Intervention Studies;Loneliness;longitudinal analysis;longitudinal database;Measurement;Measures;member;Memory Loss;Mentors;mild cognitive impairment;Mission;neuroimaging;neuropathology;Neuropsychological Tests;normal aging;older adult;optimism;Outcome;outreach;Participant;Performance;Personal Satisfaction;Persons;Pilot Projects;Population;Postdoctoral Fellow;Professional counselor;programs;Protocols documentation;psychosocial;Psychosocial Assessment and Care;psychosocial outcome;psychosocial wellbeing;Quality of life;recruit;Referral and Consultation;Research;Research Personnel;Research Project Grants;research study;Research Training;resilience;Resources;Self Efficacy;social;Social Work;successful intervention;therapeutically effective;Training;United States

PROJECT_TITLE: Psychosocial Core


ORG_CITY: AMES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: NARRATIVE: The proposed research is relevant to public health because it is expected to lead to a treatment of infections on surgical meshes following hernia repair. Such a tool would provide a noninvasive treatment option that does not currently exist reducing the number of surgeries and complications associated with hernia repair. In addition, the research will lead to improved mesh visualization by ultrasound even when no infection occurs.

PI_NAMEs: BIGELOW, TIMOTHY ALLEN (contact)

PROJECT_TERMS: Animal Model;Antibiotics;Bacteria;Cells;Clinical;contrast imaging;cost;Cytolysis;design;Devices;Effectiveness;experimental study;Fiber;Future;Glass;Goals;Grant;Hernia;Human;Image;Image-Guided Surgery;Implant;implantable device;improved;In Vitro;in vivo;Infection;Length of Stay;Lesion;Location;Mechanics;medical implant;Memory;Microbial Biofilms;Microbubbles;Microspheres;Operative Surgical Procedures;Patient Care;Patients;Performance;Physics;Physiologic pulse;Polypropylenes;porcine model;pressure;prevent;Process;Property;Public Health;Recurrence;repaired;Research;Safety;Sampling;Scheme;Surgical incisions;Surgical Mesh;targeted treatment;Testing;therapy development;Time;Tissues;tool;Transducers;Ultrasonography;ultrasound;United States National Institutes of Health;Visualization;Work

PROJECT_TITLE: Ultrasound Imaging and Treatment of Hernia Mesh

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]