NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Nutrition;Obesity;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE  Ultra-processed foods (UPFs) are emerging as an important risk factor for colorectal cancer (CRC) and may  negatively affect survival outcomes. The proposed research will study how UPFs and the molecular correlates  can impact CRC survival, leveraging large cohorts and integrating metabolomic profiling and whole-exome  sequencing data. This timely, innovative research will inform dietary recommendations for CRC patients,  contribute to the discovery of novel, actionable targets with the potential use in precision nutrition and oncology  care, and provide new insights into the design of nutrition interventions to improve long-term CRC survivorship.

PI_NAMEs: DU, MENGXI  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Acceleration;Adult;Affect;American;attributable mortality;Biological;Biological Markers;biomarker identification;Calories;Cancer Control;cancer diagnosis;Cancer Etiology;cancer statistics;cancer survival;Cancer Survivor;Cancer Survivorship;cancer therapy;Carcinogens;career;career development;Caring;Cessation of life;circulating biomarkers;clinical practice;cohort;Cohort Studies;colon cancer patients;Colorectal Cancer;colorectal cancer progression;colorectal cancer risk;comparative;Consumption;Counseling;Data;design;Diagnostic;Diet;dietary;Dietary Component;Dietary intake;Dietary Intervention;Disease;DNA Damage;Eating;epidemiologic data;epidemiology study;Etiology;exome sequencing;Follow-Up Studies;Food;food consumption;Food Processing;Gene Mutation;Genomics;Goals;Health Professional;improved;Inflammatory Response;innovation;insight;Intake;Intervention;Link;Long Term Survivorship;Malignant Neoplasms;Measures;men;Mentorship;metabolomics;Modeling;Molecular;mortality;Mutation;novel;novel marker;Nurses' Health Study;nutrition;Nutrition Policy;Nutritional Science;Obesity;Oncology;Participant;Pathway interactions;Patients;Phase;Plasma;Postdoctoral Fellow;precision nutrition;precision oncology;Process;Processed Meats;Prognosis;Prospective, cohort study;Public Health Schools;Recommendation;Relative Risks;Research;Research Project Grants;Research Training;Risk Assessment;Risk Estimate;Risk Factors;risk stratification;Role;Sampling;Schools;skill acquisition;Somatic Mutation;survival outcome;Testing;Translating;trend;tumor;Tumor Markers;tumor microenvironment;tumor progression;Tumor Tissue;Woman

PROJECT_TITLE: Integrated Epidemiologic Study of Ultra-processed Foods and Colorectal Cancer Survival


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SAN ANTONIO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PI_NAMEs: DE ERAUSQUIN, GABRIEL ALEJANDRO (contact)

PROJECT_TERMS: Acceleration;Acculturation;advanced dementia;Affect;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Apolipoprotein E;Autopsy;behavior measurement;bilingualism;biobank;Biological;Biological Assay;Biological Markers;Biology;biomarker identification;biotypes;Blood;Blood Vessels;brain morphology;care outcomes;Caregivers;Caring;Clinic;Clinical;clinical center;Clinical Research;Clinical Trials;Cognitive;Cognitive aging;cohort;Collaborations;Collection;comorbidity;Comprehensive Health Care;Consent;Data;Data Collection;data management;data quality;Data Set;data sharing;Dementia;dementia care;dementia risk;Diabetes Mellitus;Diagnosis;diagnostic criteria;Diet;Disease;Disease Progression;Education;Elements;Eligibility Determination;Enrollment;Ensure;Environment;Ethnic Origin;Family;Gait;Genetic;genome wide association study;Genomics;Genotype;Geography;Health;health care availability;Hearing;High Prevalence;high risk;hispanic community;Hispanic Populations;Image;imaging biomarker;improved;Individual;Life Style;machine learning method;Magnetic Resonance Imaging;Measures;Medical;Mexican Americans;Minority;Moods;Motor;multiple omics;neuroimaging;Neurologic;neuropathology;Neurosciences;novel;novel marker;observational cohort study;Outcome;outreach;Participant;Pathologic;Pathology;Patient Care;Patients;Pennsylvania;Persons;Phase;Phenotype;Physical activity;Population;Positron-Emission Tomography;precision medicine;Prevalence;Preventive Clinical Trial;primary caregiver;Process;Prognosis;Protocols documentation;Race;Recording of previous events;recruit;Registries;Research;resilience;resilience factor;Risk;Risk Factors;risk stratification;rural residence;Sampling;Sensory;Site;Sleep;social;social determinants;Social support;socioeconomics;South Texas;Syndrome;tau Proteins;Testing;Translational Research;trial readiness;underserved area;underserved community;United States;vascular factor;vascular risk factor;Vision;Visit;web site

PROJECT_TITLE: South Texas Alzheimer's Disease Center Clinical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Rural Health

PI_NAMEs: ZOZUS, MEREDITH NAHM (contact)

PROJECT_TERMS: advanced system;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease related dementia;Archives;Automation;Bioinformatics;Biological Markers;Clinical;Clinical Data;Clinical Informatics;clinical practice;Clinical Research;Collaborations;Collection;Communities;community partners;Data;data acquisition;Data Analyses;data cleaning;Data Collection;data dictionary;data exchange;data handling;data harmonization;data integration;data management;data quality;Data Science;Data Set;data sharing;data standards;Data Storage and Retrieval;data submission;Decentralization;design;Development;Disparate;Doctor of Philosophy;early-career faculty;Electronic Health Record;Etiology;experience;Faculty;Future;Genetic;Goals;Health;Heterogeneity;Hispanic;Hispanic Populations;Image;Informatics;information highway;Information Systems;Infrastructure;Institution;interoperability;Investigation;Machine Learning;Maintenance;Mentors;Methods;Monitor;Multicenter Studies;multiple data sources;multiple omics;neuroimaging;neuropathology;Neurosciences;next generation;nonalzheimer dementia;Nuclear Pore Complex;operation;outcome prediction;outreach;personalized intervention;Phase;Population;Population Study;Procedures;Process;programs;Quality Control;recruit;Reporting;Research;Research Design;Research Personnel;sample collection;Sampling;Services;Site;South Texas;Statistical Data Interpretation;Statistical Methods;statistics;System;Testing;Time;Training;United States National Institutes of Health;Update;Work

PROJECT_TITLE: South Texas Alzheimer's Disease Center Data and Statistical Management Core


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative This project seeks to identify the structural risk factors for glaucoma following congenital cataract surgery, a devastating adverse event impacting 30% of children after cataract removal. Comprehensive normative anterior segment structural data for infants and children does not currently exist. Ultrasound biomicroscopy image analysis will be used to build a normative baseline anterior segment database for infants and children with and without cataracts, which will be applied to identify structural risk factors or biomarkers for future development of glaucoma, allowing for earlier diagnosis and targeted treatment.

PI_NAMEs: ALEXANDER, JANET LEATH (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 5 year old;Address;Adverse event;Affect;Age;Anatomy;Anterior;aqueous;Area;Automobile Driving;Biological Markers;Biometry;Blindness;career development;Cataract;Cataract Extraction;Characteristics;Child;Child health care;Childhood;childhood cataract;Chronology;Ciliary Body;Clinical;clinical application;clinical care;Clinical Investigator;Clinical Research;cohort;Cohort Studies;comparison control;Complication;congenital cataract;Cornea;Data;Data Set;Databases;Defect;Deformity;design;Development;Diagnosis;diagnostic tool;Disease;Drainage procedure;early childhood;Early Diagnosis;Early treatment;Excision;Eye;follow-up;Foundations;Funding;Future;Glaucoma;Goals;Growth;Human;Image;Image Analysis;imaging study;Impairment;improved;Incidence;infancy;Infant;innovation;Intervention;Iris;Knowledge;lens;Master of Science;Measurable;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;ocular imaging;Onset of illness;Operative Surgical Procedures;Ophthalmology;pediatric patients;Pediatrics;Populations at Risk;pressure;prevent;Prevention;Primary Prevention;Procedures;professor;Prognosis;prospective;Research;Research Design;Research Personnel;Resolution;Risk;Risk Factors;risk prediction;Safety;Sclera;skills;statistics;structural determinants;Structure;success;surgery outcome;targeted treatment;Testing;Thinness;Time;tool;Training;treatment optimization;Ultrasonographic Biomicroscopy;Variant;Vision

PROJECT_TITLE: Identification of Anterior Segment Structural Biomarkers in Glaucoma Following Pediatric Cataract Using Ultrasound Biomicroscopy


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetic Testing;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: SESHADRI, SUDHA  (contact)

PROJECT_TERMS: Acceleration;Address;Affect;African American population;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Applied Genetics;Area;Astrocytes;biobank;Biological;Biological Markers;Biology;biotypes;Blood;Brain;catalyst;cell type;Cells;Cholesterol;Clinical;clinical sequencing;Clinical Trials;cohort;Collaborations;Communities;Comprehensive Health Care;Consensus;Consent;Creativeness;Data;data management;Data Set;decrease resilience;Dementia;Diagnosis;digital;Disease;Disease Progression;Diverse Workforce;DNA;DNA Sequence Alteration;education research;Eligibility Determination;Endowment;Enrollment;Ensure;Ethics;Extended Family;Faculty;Family;Family history of;First Degree Relative;follow-up;functional genomics;Funding;Genes;Genetic;Genetic Counseling;Genetic Diseases;Genetic Risk;genetic variant;Genetic Variation;genome sequencing;genome wide association study;genomic data;genomic epidemiology;Genomics;Genotype;Goals;graduate student;Grant;Heart;Heterogeneity;Hispanic;Hispanic Americans;Hispanic Populations;Image;improved;Individual;individual patient;individualized prevention;induced pluripotent stem cell;Inflammation;innovation;International;lipidomics;machine learning method;Magnetic Resonance Imaging;Medical;Medical Genetics;member;metabolomics;Methods;Methylation;Mexican Americans;Microglia;Mitochondria;Motor;Multiomic Data;multiple omics;Mutation;Neurons;neuropathology;Neurosciences;new therapeutic target;normal aging;Not Hispanic or Latino;novel;Nuclear Pore Complex;Office of Administrative Management;older adult;Oligodendroglia;Organoids;Participant;Pathologic;Pathway interactions;Patients;personalized medicine;Pharmaceutical Preparations;Phenotype;phenotypic data;Population;Population Heterogeneity;Positron-Emission Tomography;precision medicine;Precision therapeutics;Prevention;proband;prognostication;Publications;recruit;Research;Research Methodology;Research Personnel;Research Support;resilience;Resources;Risk;Risk Estimate;risk stratification;Sampling;Science;Sensory;Serum;single cell ATAC-seq;South Texas;symposium;Syndrome;tau Proteins;therapeutic target;Training;Training Programs;transcriptomics;usability;Validation;whole genome;Work

PROJECT_TITLE: South Texas Alzheimer's Disease Center Genetics and Multiomics Core


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition;Substance Misuse

ORG_CITY: WASHINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: CATHOLIC UNIVERSITY OF AMERICA

ORG_STATE: DC

PHR: NARRATIVE More than 22,000 people each year die of alcoholic liver disease in the US alone with estimates as high as 3.3 million deaths each year globally (5.9% of all global deaths). So clearly, alcoholic liver disease is a major biomedical health concern world-wide. We are poised to identify novel mechanisms leading to alcohol-induced liver injury and are testing novel therapeutics based on our recent findings.

PI_NAMEs: TUMA, PAMELA L. (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Acetaldehyde;Acetylation;adduct;alcohol prevention;Alcohol-Induced Disorders;Alcoholic Liver Diseases;Alcohols;Animals;Antibodies;Attenuated;Autophagocytosis;B-Lymphocytes;Biochemical;Biological Assay;Caloric Restriction;Cells;Cellular biology;cellular imaging;Cessation of life;Clinical;Coupled;Cytoprotection;Data;Deacetylation;Defect;Enzymes;Ethanol;Ethanol Metabolism;fatty acid metabolism;Fibrosis;Functional disorder;Gel;Health;Hepatic;Hepatocyte;hepatoprotective;High Fat Diet;Human;human tissue;Image;imaging facilities;Impairment;in vivo;Injury;lipid metabolism;Lipids;Liver;Liver diseases;Lysine;Mass Spectrum Analysis;Mediating;member;Membrane;Microtubules;mimetics;Mitochondria;Modification;Molecular;Monitor;Morphology;Motility;Motor;motor impairment;Mus;novel;novel therapeutics;Oleic Acids;Organ;Organelles;overexpression;Oxidation-Reduction;Oxidative Stress;Patients;peroxisome;Persons;Post-Translational Protein Processing;Predisposition;prevent;problem drinker;protective effect;Protein Acetylation;protein transport;Proteins;Protocols documentation;Rattus;reconstitution;Resources;Role;Services;Site;Slice;Spermidine;stoichiometry;Supplementation;Testing;Tissues;trafficking;translational study;Tubulin

PROJECT_TITLE: Alcohol-induced changes in protein acetylation: mechanisms and consequences

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Climate-Related Exposures and Conditions;Genetics;Human Genome;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Dysfunction of the stress response following exposure environmental insults can lead to cancer and aging as well as a wide range of other diseases. Our proposed work will provide new insights into the fundamental mechanisms by which environmental agents interact with the epitranscriptomic machinery to regulate stress response and the functional significance of dysregulated RNA modifications in environmental carcinogenesis. Our proposed work may also identify potential new druggable targets in the epitranscriptomic machinery for developing new preventive and therapeutic approaches to reduce the burden of cancer as well as other diseases.

PI_NAMEs: HE, YU-YING  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Aging;Arsenic;Biochemical;biological adaptation to stress;Cancer Burden;cancer therapy;carcinogenicity;Carcinogens;Cells;Development;Disease;DNA;DNA Repair;environmental agent;environmental carcinogenesis;Environmental Exposure;Enzymes;Epithelial Cells;epitranscriptome;epitranscriptomics;Exposure to;Functional disorder;Funding;Genetic;genome integrity;Goals;Homeostasis;Human;Impairment;improved;insight;Investigation;Knowledge;Malignant Neoplasms;Maps;Messenger RNA;Methylation;methylome;Modeling;Modification;mouse model;Mus;National Institute of Environmental Health Sciences;new therapeutic target;novel;Organism;Pathogenesis;Prevention;Preventive;programs;Publishing;Research;RNA;RNA methylation;Role;Sampling;screening;Skin;System;Technology;Testing;Therapeutic;Tissues;tumor;tumorigenesis;Ultraviolet B Radiation;ultraviolet irradiation;UV induced;Work;Xenograft procedure

PROJECT_TITLE: Epitranscriptomic mechanism of environmental stress response and tumorigenesis


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Infectious Diseases

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative: P. aeruginosa is a leading cause of blinding corneal infections that are also difficult to treat using currently available therapeutics. We have found that when these bacteria enter corneal epithelial cells, they traffic to multiple destinations wherein they express unique virulence and survival factors. Here, we will explore the significance of this intracellular diversification to the bacteria, to the host cell, and to infection in vivo, with the goal of better understanding disease pathogenesis and best practices for its management.

PI_NAMEs: FLEISZIG, SUZANNE MJ (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acute;acute infection;Adopted;Antibiotics;Antibodies;Bacteria;Bacterial Genes;Carbon;Cell Death;Cells;Chronic;chronic infection;Cornea;Corneal Diseases;corneal epithelium;Cytoplasm;Cytosol;Data;Destinations;differential expression;Disease;Epithelial Cells;Epithelium;extracellular;Eye diseases;Eye Infections;Funding;Gene Expression Regulation;Genetic;Goals;Grant;Human;Image;Imaging technology;In Situ;In Vitro;in vivo;Individual;Infection;inhibitor;Invaded;Label;Location;Mediating;Membrane;Metabolic;Methods;Microbial Biofilms;Modeling;mouse model;Mus;mutant;novel;opportunistic pathogen;Outcome;Outcomes Research;pathogen;Pathogenesis;Pathology;Pattern;Penetration;Phenotype;Plasma;Population;Predisposition;Probability;Proteins;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Publishing;Regulation;Reporter;Reporting;Resistance;response;Role;Small RNA;Starvation;Sterilization;synergism;Testing;Therapeutic;TNF gene;tool;trafficking;Type III Secretion System Pathway;Ulcer;Vacuole;Virulence;Visualization;Work

PROJECT_TITLE: Significance of Corneal Cell Invasion by Bacteria


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: BIENIEK, KEVIN F (contact)

PROJECT_TERMS: Address;aging brain;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;Archives;Area;ATAC-seq;Attention;Autopsy;Bar Codes;Basic Science;Behavior;biobank;Biological Markers;Brain;Brain region;brain tissue;Central Nervous System;Cerebrospinal Fluid;cerebrovascular;Cerebrovascular Trauma;Cities;Classification;Clinic;Clinical;Clinical assessments;clinical diagnosis;Cognitive;cohort;Communities;Comprehensive Health Care;cost;Data;data management;Data Set;Databases;demented;Dementia;Diagnosis;Diagnostic;digital;digital pathology;Disease;Dissection;DNA;DNA analysis;Doctor of Philosophy;Education;education research;endophenotype;Epigenetic Process;ethnic diversity;Ethnic Population;ethnoracial;Etiology;Evaluation;exome sequencing;experimental study;Family;Fostering;Freezing;frontotemporal lobar dementia amyotrophic lateral sclerosis;Future;Gene Expression;Genetic;Genetic Counseling;Genetic Polymorphism;genetic testing;Genetic Variation;genomic data;Genomics;Glial Fibrillary Acidic Protein;Goals;Hematoxylin and Eosin Staining Method;Heterogeneity;Hispanic;Hispanic Americans;hispanic community;Hispanic Populations;histological stains;Histology;Human Resources;Image;Individual;induced pluripotent stem cell;Institution;interest;Interview;Liquid substance;Magnetic Resonance Imaging;Medical Genetics;Medical Records;Messenger RNA;metabolomics;Methodology;Methylation;metropolitan;Mexican Americans;Mission;Molecular;multidisciplinary;multiple omics;nano-string;Natural History;Nerve Degeneration;Neuroanatomy;Neurodegenerative Disorders;neurofilament;neuropathology;Neurosciences;Neurosciences Research;normal aging;Not Hispanic or Latino;novel;Outcome;outreach;Participant;Pathogenesis;Pathologic;Pathology;Patients;Persons;Plasma;Population;population based;pre-clinical;precision medicine;preservation;protein biomarkers;protein TDP-43;Proteomics;Protocols documentation;racial diversity;recruit;repository;Research;Research Personnel;Research Project Grants;Resources;RNA;Role;Sampling;Scanning;Scientist;Services;Skin;Slide;South Texas;Spinal Cord;Stains;Standardization;statistics;Students;System;tau Proteins;Texas;Thioflavin S;Tissues;Training;trait;Transcript;transcriptomics;Translational Research;Traumatic Brain Injury;United States;Variant

PROJECT_TITLE: South Texas Alzheimer's Disease Center Neuropathology Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CINCINNATI

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative CRAC channels are one of the primary Ca2+ influx pathways in nearly all cell types and generate Ca2+ signals critical for many cellular functions. Gain- and loss-of-function mutations in CRAC channel genes lead to diseases in which various tissues and cell types are affected, suggesting diverse physiological and pathophysiological roles CRAC channels play in human health and disease. Here, I present a basic research program to study the molecular regulation of the CRAC channel signaling pathway, which will help uncover the molecular mechanisms underlying the diverse functions of CRAC channels and facilitate development of therapeutics for treating CRAC channel-associated diseases.

PI_NAMEs: HOU, XIAOWEI  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;Affect;Basic Science;Biochemical;Biochemistry;Calcium;Calcium Channel;Calcium Signaling;Cell membrane;Cell Physiology;cell type;Cells;Complex;Cryoelectron Microscopy;Disease;Drosophila genus;Endoplasmic Reticulum;experience;Foundations;gain of function;gain of function mutation;Genes;Goals;Health;Human;human disease;innovation;Ion Channel;Knowledge;Lead;Lipids;loss of function;loss of function mutation;Mammals;Mediating;Membrane;Methods;Molecular;novel;Pathologic;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Physiological;Play;Principal Investigator;programs;protein protein interaction;Proteins;Regulation;Research;response;Role;sensor;Signal Pathway;Signal Transduction;small molecule;STIM1 gene;structural biology;Structure;therapeutic development;Tissues;tool;X-Ray Crystallography

PROJECT_TITLE: Molecular regulation of the CRAC channel signaling pathway

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


ADMINISTERING_IC: AI

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: DURHAM

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narrative Systemic lupus erythematosus (SLE or lupus) is an autoimmune disease that primarily affects young women, especially African Americans. The basis of this disease is not well understood and current treatments are often ineffective. This research will develop well-controlled model systems to recapitulate the immunological effects of DNA-particles, which are key mediators of inflammation in SLE, to provide new insights into disease mechanisms and inform new approaches for therapy. 0

PI_NAMEs: PAYNE, CHRISTINE K (contact);PISETSKY, DAVID STEPHEN

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Address;Adsorption;Affect;African American;African American population;American;Animal Model;Antibodies;Antigen-Antibody Complex;Antigens;Antinuclear Antibodies;Apoptosis;Autoimmune Diseases;Automobile Driving;Base Pairing;Behavior;Binding;Biochemical;Biological;Biological Assay;Biological Markers;Biological Models;Blood;Blood Vessels;Cell Death;cell free DNA;Cell Line;Cell model;Cells;child bearing;Classification;Coated vesicle;Complement;Complex;Confocal Microscopy;cytokine;Data;Deposition;Development;Diagnosis;Diameter;Digestion;Disease;DNA;DNA Binding;Elements;Engineering;Epitopes;European;Event;experimental study;extracellular;extracellular vesicles;Future;Immune;Immune response;Immunologic Stimulation;Immunological Models;Immunologics;improved;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Injury;Injury to Kidney;innovation;insight;Interleukin-6;Kidney;Length;Liquid substance;Lupus;Macrophage;Malignant - descriptor;Measures;Membrane;Molecular Weight;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mus;nano;nanoparticle;Nephritis;Nitric Oxide;novel therapeutic intervention;Nuclear;nuclease;Nucleic Acids;Organ;Outcomes Research;particle;Pathogenesis;Patients;Phagocytes;Polystyrenes;Production;Property;Proteins;prototype;Research;Research Personnel;response;Role;serological marker;Serology;side effect;Source;Surface;synthetic construct;System;Systemic Lupus Erythematosus;tissue culture;Tissues;TNF gene;uptake;young woman

PROJECT_TITLE: Engineered DNA-particles to model immune events in systemic lupus erythematosus


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: CAVAZOS, JOSE E (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;analytical method;aphasia rehabilitation;Astrocytes;Attitude;Award;Basic Science;Behavioral;Big Data;Biological Markers;Biology;Biometry;Blood;Blood Pressure;Blood Vessels;Capsicum;career;Caregiver Burden;Caring;Clinical;Clinical Trials;cohort;Communication;community engagement;community-centered;Congresses;connectome;cost of dementia;Data;data sharing;Dementia;dementia care;Development;digital;Discipline;Doctor of Philosophy;Doctor's Degree;Education;education research;Environment;Epidemiology;Epigenetic Process;Ethnic Origin;experience;Face;Faculty;flexibility;Fostering;Funding;Genetic;Goals;Grant;Growth;Health;health disparity;Health Professional;healthy lifestyle;Hispanic;hispanic community;Hour;Image;improved;Inflammation;insight;Instruction;Knowledge;Laboratories;Latino Population;Learning;Length;lifestyle intervention;Machine Learning;Magnetic Resonance Imaging;Malignant Neoplasms;Mentors;Metabolic;metabolomics;Methods;Mexican Americans;Microglia;Military Personnel;Mind;Minority;Minority Access;minority investigator;mixed dementia;neurocognitive test;Neurodegenerative Disorders;neuroregulation;Neurosciences;new technology;Pathway interactions;Patients;Pattern;peer;person centered;Persons;Population;Population Sciences;Population Study;Populations at Risk;Positron-Emission Tomography;pre-clinical;precision medicine;Prevention;Prevention strategy;Program Effectiveness;programs;Protein Isoforms;Proteomics;public health intervention;racial diversity;radioligand;recruit;Research;Research Personnel;Research Support;resilience;resilience factor;Risk Factors;risk stratification;Science;Scientist;senior faculty;Shock;skills;social;Social Sciences;South Texas;Systems Biology;Tablets;tau Proteins;Technology;Time;Training;Translations;treatment strategy;Underrepresented Minority;United States National Institutes of Health;Vocational Guidance;Woman

PROJECT_TITLE: South Texas Alzheimer's Disease Center Research and Education Core


ADMINISTERING_IC: CA

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Cancer;Liver Disease;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Substance Misuse;Substance Misuse Prevention

ORG_CITY: KINGSTON

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: NARRATIVE Chronic alcohol consumption is a major risk factor for the development of hepatocellular carcinoma (HCC) – the fastest growing type of cancer worldwide. Current therapies to treat and prevent alcohol liver disease progression are non-specific and toxic. The main objective of this proposal is to develop a novel multifunctional nanoparticle formulation that can penetrate deep into the fibrotic liver tissue to provide combination therapy to prevent alcohol- induced liver tumorigenesis.

PI_NAMEs: MENON, JYOTHI UNNIKRISHNA (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: 3-Dimensional;Accounting;Adverse effects;Affect;Agonist;alcohol abstinence;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol prevention;Alcoholic Liver Diseases;Alcohols;antifibrotic treatment;Attenuated;attenuation;Bile Acids;Biodistribution;Biological Assay;Biological Markers;Cancer Etiology;cancer type;Carbon Tetrachloride;Cells;Cellular Spheroids;Cessation of life;Charge;Cholestasis;Chronic;chronic alcohol ingestion;chronic liver disease;chronic liver injury;Cirrhosis;Clinic;Clinical;Collaborations;Collagen;collagenase;Combined Modality Therapy;Coupled;cytokine;Cytokine Signaling;Data;Deposition;design;Development;Diameter;Disease;Disease Progression;Drug Delivery Systems;effective therapy;Encapsulated;Evaluation;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Fatty Liver;Fibrosis;Formulation;Functional disorder;G13 Protein;Goals;GTP-Binding Proteins;Hepatic;Hepatitis;Hepatocarcinogenesis;Histology;Human;improved;In Vitro;in vivo;in vivo evaluation;Individual;Inflammation;Inflammatory;inhibitor;Injury;innovation;Interleukins;Intervention;Intravenous;Investigation;Kupffer Cells;Ligands;Lipids;Liver;Liver diseases;Liver Fibrosis;liver inflammation;liver injury;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane Proteins;Modeling;Molecular Target;mortality;mouse model;Mus;nanoparticle;nanoparticle delivery;nanopolymer;novel;novel therapeutic intervention;novel therapeutics;Outcome;Pathway interactions;Penetration;Pharmaceutical Preparations;Polymers;Positioning Attribute;pre-clinical assessment;prevent;Primary carcinoma of the liver cells;Production;Property;receptor;Receptor Activation;Reporting;Reproducibility;Research;Rhode Island;Risk Factors;Safety;Signal Transduction;small molecule;Specificity;STAT3 gene;Surface;Testing;Therapeutic;Therapeutic Effect;Therapeutic Studies;Tissues;translational potential;Tretinoin;United States;United States National Institutes of Health;Universities;uptake;Validation;Work

PROJECT_TITLE: Multifunctional Nanoparticle Platform to Prevent Alcohol-Associated HCC Development


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Bipolar Disorder;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research

ORG_CITY: IOWA CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: The rate of mortality by suicide is approximately twenty times higher in psychiatric disorders as compared to the general population. Among psychiatric disorders, bipolar disorder (BD) has the highest rate of attempts (~40%), which is 2-3 times higher than in major depressive disorder (MDD). This study will evaluate brain circuits involved in suicidal behavior in these major psychiatric disorders.

PI_NAMEs: MAGNOTTA, VINCENT A (contact);WEMMIE, JOHN A

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: Algorithms;Anatomy;Anterior;Back;Behavior;Bipolar Depression;Bipolar Disorder;Brain;Brain imaging;Cell Nucleus;Cerebellar vermis structure;Cerebellum;connectome;Coupled;Data;Dependence;Diffusion;Disease;Dorsal;Exclusion;Exhibits;Failure;Feeling suicidal;frontal lobe;Functional Magnetic Resonance Imaging;Future;General Population;Globus Pallidus;Goals;Image;imaging study;Impulsivity;Individual;Inferior;Knowledge;Lateral;Magnetic Resonance Imaging;Major Depressive Disorder;Measurement;Measures;Mediating;Mental disorders;Metabolic;Metabolism;Modeling;Mood Disorders;Moods;multimodality;neural circuit;Neurobiology;new therapeutic target;Parietal Lobe;Participant;Personality Traits;Play;Prefrontal Cortex;prospective;Psychiatric Diagnosis;psychiatric symptom;random forest;reducing suicide;Regulation;response;Rest;Risk;Role;routine screening;Sampling;screening;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide attempter;suicide mortality;suicide rate;Surface;Testing;Thalamic structure;Work

PROJECT_TITLE: Suicidality in Bipolar and Major Depression Disorders

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Glaucoma is a leading cause of blindness and optic nerve head (ONH) biomechanics are thought to play an important role. We will use continuous intraocular pressure (IOP), cerebrospinal fluid pressure (CSFP) and translaminar pressure gradient (TLPG) telemetry, along with in vivo measurements of TLP-induced ONH deformations, to determine if IOP fluctuations, and CSFP or TLPG contribute to the eye-specific susceptibility to glaucoma onset and progression, and if IOP and CSFP are coupled via neural pathways. The knowledge gained from these studies will drive future development of glaucoma diagnostics and new therapeutic strategies.

PI_NAMEs: DOWNS, J CRAWFORD (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: absorption;Accounting;Acute;Address;Adult;Age;Animal Model;aqueous;Axon;axon injury;behavior prediction;Bilateral;Biomechanics;Blindness;Brain;Cerebrospinal Fluid Pressure;Clinical Research;Connective Tissue;Coupled;Coupling;Data;Development;Diagnostic;Disease;Disease Progression;Exhibits;Eye;Functional disorder;Future;Glaucoma;Goals;Height;Hour;Human;Implant;in vivo;Individual;insight;instrument;Intracranial Pressure;Knowledge;loss of function;Macaca mulatta;Measurable;Measurement;Measures;mechanical energy;Mechanics;Modeling;Monitor;Morphology;neural;Neural Pathways;novel therapeutic intervention;novel therapeutics;Onset of illness;Optic Disk;Optic Nerve;Pathogenesis;Pathway interactions;Patients;Physiologic Intraocular Pressure;Play;Predisposition;pressure;Primates;Rattus;Reporting;response;Retina;Retinal Ganglion Cells;retinal nerve fiber layer;Risk;Risk Factors;Role;Sleep;Stress;Structure;System;Telemetry;Testing;Therapeutic;Thick;Thinness;Tissues;translaminar pressure gradient;transmission process;Vision;visual information

PROJECT_TITLE: IOP and Cerebrospinal Fluid Pressure-related Risk Factors for Glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE Hundreds of thousands of disease-causing changes have been identified in the DNA of individuals with disease, yet only a fraction of those changes, and their associated interpretations, are accessible to researchers, clinicians and patients. This proposal will build upon ClinGen’s successful foundation to collect, organize and interpret genomic evidence from global sources and distribute the resulting knowledge into publicly accessible databases for use in precision medicine and research.

PI_NAMEs: DISTEFANO, MARINA ;MARTIN, CHRISTA LESE;REHM, HEIDI L (contact);RIGGS, ERIN ROONEY

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Acceleration;Address;Applications Grants;Area;base;Basic Science;Biotechnology;Caring;Classification;Clinical;Clinical Research;clinically relevant;ClinVar;cohort;Communities;community building;Copy Number Polymorphism;crowdsourcing;Data;data access;Data Set;data sharing;Data Sources;data streams;Databases;Dedications;design;Disease;disorder risk;diverse data;DNA;dosage;Elements;Ensure;Environment;Foundations;Future;Gene Dosage;Gene Structure;Genes;Genetic Structures;genetic variant;Genome;genome repository;genome resource;genomic data;Genomic medicine;genomic variation;Genomics;Goals;Guidelines;Health;hearing impairment;Human;human disease;Human Genome;improved;Individual;Kidney;Knowledge;knowledge of results;Laboratories;Leadership;Link;Medical;Medicine;Methods;Modality;Mutation;Needs Assessment;neuromuscular;North Carolina;novel strategies;Online Systems;Pathogenicity;patient registry;Patients;Penetrance;phenotypic data;precision medicine;Process;Professional Organizations;public database;repository;Research;Research Personnel;Resolution;Resources;risk prediction;risk variant;skeletal disorder;Source;Standardization;Technology;Test Result;Testing;tool;Training Programs;Translations;Underrepresented Populations;Universities;Variant;variant detection;volunteer;web site;Work

PROJECT_TITLE: Broad-Geisinger Clinical Genome Resource


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: SYDNEY

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: UNIVERSITY OF SYDNEY

PHR: PROJECT NARRATIVE Addiction is characterized by drug-related information dominating behavior. This project will focus on the circuit mechanisms that bias learning towards information proximal to rewards, opposing learning about more complex relationships in the environment. We will test if strengthening of these circuits potentiates cue-elicited drug seeking, at the expense of more complex learning strategies, producing the reinforcement-learning deficits seen in addiction.

PI_NAMEs: SHARPE, MELISSA  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TITLE: The role of the lateral hypothalamus in the balance of learning and behavior towards relevant stimuli

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Excessive alcohol use is the 3rd leading preventable cause of death in the U.S., and is associated with significant economic burden and negative health-related consequences that are undertreated in rural regions. This K23 involves evaluating two remotely-delivered behavioral economic intervention components using remote text message delivery that will lead to the development of a well-specified, novel mobile health intervention for rural risky drinkers. Given the high rates of mobile phone ownership, if the efficacy is established, this intervention will have great promise for increasing access to alcohol intervention services for rural individuals, thereby benefiting public health.

PI_NAMEs: COUGHLIN, LARA NICOLE (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: access disparities;addiction;Address;alcohol availability;Alcohol consumption;alcohol demand;alcohol intervention;alcohol misuse;alcohol related consequences;Alcohols;Automobile Driving;behavior change;Behavior Therapy;behavioral economics;career development;Cause of Death;Cellular Phone;Characteristics;Clinical;Clinical Psychology;Collaborations;Collection;Data;Development;Development Plans;discounting;Disparity;drinking;early alcohol use;Ecological momentary assessment;Economic Burden;Economic Models;Educational workshop;effective intervention;Effectiveness;Ensure;Equity;Evaluation;experience;Feedback;field study;Fostering;Funding;Future;Goals;Health;health disparity;Health Services Accessibility;high risk drinking;improved;Individual;innovation;insight;Intervention;intervention refinement;Interview;knowledge base;Mentorship;method development;Methods;mhealth interventions;Mission;mobile delivery;Morbidity - disease rate;mortality;multi-component intervention;multiphase optimization strategy;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;Ownership;Participant;Pathology;patient oriented;Phase;Population;preference;Preparation;prevent;Primary Care;Procedures;Productivity;Psychologist;Public Health;Randomized;recruit;Reduce health disparities;reduced alcohol use;reinforcer;remote delivery;repaired;Research;Research Activity;Research Personnel;Research Support;Rewards;Rural;rural America;rural Americans;rural area;Rural Developments;Rural Population;rural residence;satisfaction;service intervention;Services;skills;Specific qualifier value;Strategic Planning;Substance of Abuse;symposium;Technology;technology intervention;Testing;Text Messaging;theories;therapy development;Thinking;Time;Training;Training Activity;Underserved Population;usability

PROJECT_TITLE: Optimizing mobile behavioral economic interventions for rural risky drinkers

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA(03)-3]


NIH_SPENDING_CATS: Clinical Research;Genetics;HIV/AIDS;Infectious Diseases;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Significant sex differences have been reported in the immune response to HIV-1 infection. This project will examine the mechanisms by which women and men differ in immune activation, viral control, and disease progression in response to HIV infection in the absence and presence of anti-retroviral treatment.

PI_NAMEs: HUNTER, ERIC  (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acute;acute infection;Age;antiretroviral therapy;Cause of Death;CD4 Positive T Lymphocytes;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Chronic Phase;cohort;comorbidity;Complex;CRISPR/Cas technology;Disease;Disease Outcome;Disease Progression;Disease remission;Dose;effective therapy;Epidemiology;Estradiol;Exhibits;experimental study;Flow Cytometry;Future;Gene Expression Profile;Gene Expression Regulation;gene function;Genes;Genetic;Genetic Transcription;Gonadal Steroid Hormones;Grant;Growth;HIV Infections;HIV-1;Hormonal;immune activation;Immune response;Immunologic Factors;Immunologics;Immunophenotyping;In Vitro;in vivo;Individual;Infection;Interferon Type I;Interferons;Intervention;latent virus activation;Mediating;men;Molecular;Nature;Outcome;Pathogenesis;Pathway interactions;Peripheral;Peripheral Blood Mononuclear Cell;Phenotype;Population;Predisposing Factor;Predisposition;Premenopause;Production;recruit;Reporting;reproductive;Resolution;response;Sampling;sex;Sex Differences;Signal Transduction;Source;T-Cell Activation;Technology;Time;Transcript;transcriptome sequencing;transmission process;Up-Regulation;Vial device;Viral;Viral Load result;Virus;Virus Replication;Woman;Women's mortality;Zambia

PROJECT_TITLE: Deciphering the impact of sex in early subtype C HIV infection and during HART

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences;Prevention;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_DEPT: NEUROLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative  Little is known about how inherited risks for alcohol use disorders (AUD) affect large scale brain networks. Moreover, all such research ignores critical periods when brain activity changes in transition to different mental states. We will determine how AUD risks impair functional network connectivity flexibility during changes in mental state—information needed to develop brain based biomarkers for prevention and treatment research.

PI_NAMEs: DZEMIDZIC, MARIO ;KAREKEN, DAVID A. (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Affect;alcohol cue;alcohol related problem;alcohol risk;alcohol use disorder;Alcohols;Attention;Behavior Control;Behavioral;Biological Markers;biological sex;Brain;brain based;Brain region;Cognitive;cognitive change;cognitive control;cognitive function;cognitive load;cognitive task;connectome;craving;critical period;cue reactivity;Data;Desire for food;discounting;Disease;disorder risk;drinking;drinking behavior;executive function;Exposure to;externalizing behavior;Family history of;flexibility;Functional impairment;Goals;Hair;Impulsivity;incentive salience;Inherited;Joints;Knowledge;male;Mediation;mental state;Methods;Monitor;negative affect;novel;Outcomes Research;Pathway interactions;Pattern;Phenotype;Prediction of Response to Therapy;Prevention Research;problem drinker;Psychopathology;Publishing;Regulation;Research;response;Rest;Rewards;Risk;Risk Factors;sample fixation;Services;support network;System;Taste Perception;Testing;treatment research;treatment response;Work

PROJECT_TITLE: Functional connectivity reconfigurations in risk for alcohol use disorders

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Eye Disease and Disorders of Vision;Infectious Diseases;Nanotechnology;Prevention

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Each year in the US alone, there are millions of cases of bacterial keratitis and conjunctivitis. Antibiotic eye drops must be used at least three times per day, and up to once every hour for severe infections, leading to issues with adherence, efficacy, and bacterial resistance. Here, we describe the development of mucus-penetrating particle (MPP) ion-paired nanosuspension formulations for enhanced intraocular delivery of water-soluble antibiotics with less frequent dosing.

PI_NAMEs: ENSIGN, LAURA  (contact);HANES, JUSTIN S.

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: absorption;Acids;Adherence;Adhesions;Antibiotics;antimicrobial;Bacteria;Bacterial Infections;Bacterial Model;bacterial resistance;Biological Availability;biomaterial compatibility;Blinking;Clinical;Complex;Conjunctivitis;Contact Lenses;Data;design;Development;Dose;Drainage procedure;Drug Delivery Systems;Drug Kinetics;Effectiveness;efficacy study;efficacy testing;Eye;Eye Infections;Eyedrops;female reproductive tract;Film;Fluoroquinolones;Formulation;Frequencies;Gastrointestinal tract structure;Genus staphylococcus;Goals;Hour;Human;improved;In Vitro;Infection;Infection prevention;innovation;Ions;Keratitis;Marketing;Methicillin Resistance;Minimum Inhibitory Concentration measurement;Modeling;Moxifloxacin;Mucins;Mucous body substance;Mucous Membrane;nano;nanoparticle;Organism;Oryctolagus cuniculus;particle;Particle Size;pathogen;pathogenic bacteria;Patient Care;Patient Compliance;Patient-Focused Outcomes;Penetration;Pharmaceutical Preparations;Pharmacologic Substance;Prevention;Production;Property;Proteins;Pseudomonas;Pseudomonas aeruginosa;Quality of life;Rattus;residence;Resistance;Safety;safety study;Salts;Staphylococcus aureus;Staphylococcus aureus infection;Structure;Surface;surface coating;Surface Properties;Suspensions;Technology;Testing;Time;Treatment Efficacy;Vision;Water

PROJECT_TITLE: Eye drop formulations for enhanced penetration of water soluble antibiotics to treat infections

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: Aurora

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Publicly increase data limiting methods heterogeneity, summary available genetic summary data (e.g. genotype f requencies in diverse ancestries) can the understanding of health and disease. Many methods that use this genetic summary are biased due to the underlying and unobserved heterogeneity within the data sets, the use of this resource for understudied or admixed ancestries. Here, I develop that use summary genetic and genomic data while estimating and modeling the thus increasing the r obustness and effectivenes s of publicly available genetic data for genetic research and precision medicine.

PI_NAMEs: HENDRICKS, AUDREY E (contact)

PROGRAM_OFFICER_NAME: KULCHAK RAHM, ALANNA LEE

PROJECT_TERMS: aggregation database;Bioconductor;case control;causal variant;Data;Data Analyses;data resource;Data Set;Databases;detection method;Disease;Equity;Frequencies;Genetic;genetic element;Genetic Predisposition to Disease;Genetic Research;genetic variant;Genome;genome wide association study;genomic data;Genotype;Health;Heterogeneity;Individual;innovation;insight;Internet;Maps;Methods;Modeling;polygenic risk score;precision medicine;Rare Diseases;Resources;statistics;Techniques;Testing

PROJECT_TITLE: Methods to enable robust and efficient use of genetic summary data


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative: We propose to study the genetics of agenesis of the corpus callosum (ACC), a key structural sign of disrupted brain development. Large groups of participants will enhance gene discovery and will place us in an optimal position from which to study the biology of ACC in animal models and human cell models.

PI_NAMEs: SHERR, ELLIOTT  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Affect;Aicardi's syndrome;AMPA Receptors;Animal Model;Architecture;autism spectrum disorder;Binding;Biological Models;Biology;Biotinylation;Brain;Brain imaging;brain malformation;brain tissue;Candidate Disease Gene;Caring;Cell model;Cerebral hemisphere;Cerebral Palsy;Cerebrum;Clinical;Clinical Data;clinical phenotype;Code;Cognition Disorders;cohort;Collaborations;Communities;Complex;Corpus Callosum;CREB1 gene;Data;de novo mutation;Development;Disease;Enrollment;Ensure;Epilepsy;exome;exome sequencing;Family;fetal;Fiber;Foundations;gene discovery;Genes;Genetic;genetic information;Genetic Predisposition to Disease;Genetic study;Genetic Variation;Genome;genome-wide;Genomic Segment;Genomics;Germ Lines;Glutamates;Goals;Grant;Hand;Human;imaging study;improved;Incidence;Inherited;insertion/deletion mutation;Intellectual functioning disability;International;Laboratories;Link;Modeling;Mus;Mutation;nanopore;Neurodevelopmental Disorder;Neurology;neuronal excitability;Neurons;NFIB gene;novel;outreach;Parents;Participant;Patients;Phenotype;Play;Population;Positioning Attribute;postnatal;Probability;Proteins;Public Health;rare condition;receptor;receptor recycling;recruit;Regulation;Research;Role;Schizophrenia;Signal Pathway;Synaptic plasticity;Synaptic Transmission;Syndrome;Testing;Tissues;transcription factor;treatment strategy;Validation;Variant;Work

PROJECT_TITLE: ACC: Callosal Agenesis as a Window into Common Neurodevelopmental Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-Z(02)M]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Complementary and Integrative Health;Natural Products;Pediatric

PHR: PROJECT NARRATIVE The University of Rhode Island proposes the development of a new program to cultivate STEM learning for high school students. This program – HERBAL: Hands-on Education and Research for Biomedical and Analytical Learning – is composed of teacher training workshops followed by an academic year laboratory paired with game-based learning modules centered on molecules from medicinal plants. The academic year course will be followed by hands-on summer research with student-generated data at the University of Rhode Island. The HERBAL program will serve as an excellent entry point for life-long STEM learning, and it will connect plants with their cultural and traditional importance to human health and well-being, and HERBAL will increase student access to cutting-edge analysis and informatics tools to understand the metabolite composition of these plants.

PI_NAMEs: ROWLEY, DAVID C (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: Biomedical Research;Biotechnology;career;CCL7 gene;Chromatography;Clinical;Collaborations;college;Computers;Core Facility;Creativeness;Curiosities;Custom;Data;design;Development;digital media;Drug Compounding;drug discovery;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Enrollment;Environment;Equipment;Event;experience;Faculty;faculty mentor;Food;Funding;Future;Game Based Learning;Geography;Goals;Government;Growth;Health;Herbal Medicine;High Pressure Liquid Chromatography;high school;High School Faculty;High School Student;high throughput screening;Home;Human;Imagination;Industrialization;Informatics;informatics tool;innovation;inquiry-based learning;Institution;Instruction;instructor;instrumentation;interest;junior high school;Laboratories;laboratory curriculum;Learning;Learning Module;Libraries;liquid chromatography mass spectrometry;literacy;Mass Spectrum Analysis;mathematical learning;Medicinal Plants;Medicine;Mentors;Mentorship;method development;Methods;Molecular Biology;Names;neighborhood disadvantage;online classroom;Online Systems;Participant;peer coaching;Personal Satisfaction;Pharmaceutical Chemistry;Pharmacy facility;Plant Extracts;Plants;Positioning Attribute;Problem Solving;programs;Property;Research;Research Personnel;Resources;Rhode Island;Role;rural area;Sampling;Science;Science, Technology, Engineering and Mathematics;secondary metabolite;Services;skills;Societies;Source;Specimen;student training;Students;summer program;summer research;teacher;Teacher Professional Development;teaching laboratory;Techniques;Technology;theories;Therapeutic;Traditional Medicine;Training;Translating;undergraduate research experience;undergraduate student;Underrepresented Populations;Universities;urban area

PROJECT_TITLE: Hands-on Education and Research for Biomedical and Analytical Learning (HERBAL)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LAS VEGAS

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: PROJECT NARRATIVE  A vertebrate model for studying mechanisms of embryonic eye regrowth will bring new insights for understanding the ability of an animal to successfully repair eye injuries and identify methods to induce regenerative repair. The impact of this study is to add a new dimension to the knowledge of regeneration and developmental biology with the potential towards devising new strategies for restoring damaged or diseased tissues.

PI_NAMEs: TSENG, KELLY  (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Ablation;Adult;Age;Animals;bioelectricity;Biological Assay;Biology;Biomedical Research;Cell Compartmentation;Cell Cycle;Cell Maintenance;Cell membrane;cell type;Compensation;Data;Dependence;Development;Developmental Biology;Dimensions;Disease;Drosophila genus;Embryo;Embryonic Development;Embryonic Eye;Environment;Event;Excision;Exhibits;Eye;Eye Development;eye formation;Eye Injuries;Failure;Foundations;gain of function;Gene Expression;Generations;Genes;Genetic Epistasis;Goals;Growth;Growth and Development function;Histologic;Human;in vivo;Injury;insight;interest;Knowledge;Left;limb regeneration;Link;Location;loss of function;Maintenance;Membrane;Methods;Microsurgery;minority student;Minority-Serving Institution;Modeling;Mus;Natural regeneration;nerve stem cell;Neuronal Differentiation;notch protein;novel;Operative Surgical Procedures;Organ;organ regeneration;Organelles;Pathway interactions;Pattern;Plasma;Process;Productivity;programs;Protocols documentation;Proton Pump;Proton-Translocating ATPases;Rana;regenerative;regenerative biology;regenerative repair;Regulation;repair strategy;repaired;Research;retinal progenitor cell;retinal regeneration;Role;Sagittaria;Signal Pathway;Signal Transduction;Site;spatiotemporal;stem cell proliferation;stem cells;Structure;student participation;Study models;System;Tadpoles;Tail;Testing;Time;tissue repair;Tissues;Transcript;Vision;Visual Fields;voltage;Xenopus;Xenopus laevis;Yeasts;Zebrafish

PROJECT_TITLE: Regulation of Eye Regrowth in Xenopus laevmis


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Dementia;Heart Disease;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Sleep Research

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Adverse changes in movement, sleep, and heart rhythms are common with advancing age, and may precede, or co-occur with, the onset and progression of Alzheimer's disease and related dementias. Wearable technology facilitates extended, monitoring of detailed digital physiologic signals related to movement, sleep and heart rhythms in free-living settings, providing great potential to detect early changes in physical and cognitive functioning that may reflect the development and progression of pathology related to Alzheimer's disease and related dementias. In the proposed research, we will examine the independent and joint associations of digital measures of movement, sleep and heart rhythms with measures of brain and cognitive health (e.g., β-amyloid, atrophy, cognitive decline, cognitive diagnosis) to identify clinically relevant digital biomarkers that will facilitate earlier detection of adverse risk profiles, when interventions and treatments may be more effective.

PI_NAMEs: CHEN, LIN YEE;CRAINICEANU, CIPRIAN M;SCHRACK, JENNIFER ANN (contact);SPIRA, ADAM PETER

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: abeta deposition;Accelerometer;Address;adjudication;Alleles;Alzheimer disease detection;Alzheimer's disease related dementia;Amyloid beta-Protein;Apolipoprotein E;Atherosclerosis Risk in Communities;Atrial Fibrillation;Atrial Premature Complexes;Atrial Tachycardia;Atrophic;Blood Vessels;Brain;brain health;brain magnetic resonance imaging;Brain Pathology;circadian;Clinical;clinically relevant;Cognitive;cognitive change;cognitive function;cognitive performance;cognitive testing;cost effective;Data;Data Collection;Dementia;dementia risk;Development;Diagnosis;digital;digital applications;Digital biomarker;digital measure;digital technology;Disease;Early Diagnosis;Elderly;Electrocardiogram;Environment;Exhibits;fighting;follow-up;Free Association;Frequencies;functional decline;Future;Genetic;Goals;Health;Heart Abnormalities;heart rate variability;heart rhythm;high risk;Impaired cognition;improved;Individual;individual variation;Intervention;Joints;Knowledge;Link;Measures;mild cognitive impairment;Monitor;Movement;Multivariate Analysis;Nerve Degeneration;Neurocognitive;neuroimaging;Neuropsychology;novel;older adult;Participant;Pathology;Pathway interactions;Pattern;Phase;Phenotype;Physical activity;Physical Function;Physiological;poor sleep;Positron-Emission Tomography;Prevention trial;Principal Component Analysis;Research;response;Rest;Risk;Risk Factors;Role;screening;sedentary;Severities;sex as a biological variable;Signal Transduction;Sleep;sleep abnormalities;Sleep Fragmentations;sleep onset;Time;tool;Variant;Ventricular Premature Complexes;Ventricular Tachycardia;wearable device;White Matter Disease;β-amyloid burden

PROJECT_TITLE: Novel application of Digital signals of movement, sleep and heart rhythms for detection of Alzheimer's Disease and Related Dementias


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Epilepsy;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Rehabilitation;Serious Mental Illness

PHR: Project Narrative This research will help develop our understanding of how repetitive transcranial magnetic stimulation and electrical stimulation affect the brain. We will explore a new method for characterizing brain activity changes induced by repetitive stimulation, taking advantage of the high spatial and temporal accuracy possible with intracranial recordings. This research will shed light on mechanisms of repetitive stimulation across brain networks and facilitate optimization of neurostimulation protocols and potentially generation of novel treatment protocols for neuropsychiatric diseases.

PI_NAMEs: TRAPP, NICHOLAS THOMAS (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Affect;Anterior;anti-depressive agents;antidepressant effect;Area;Beds;Brain;Brain Diseases;Brain region;career;cingulate cortex;Clinical;Clinical Trials Design;Data;depressed patient;design;disability;Disease remission;Electric Stimulation;Electroencephalography;Electrophysiology (science);Emotional;Environment;Epilepsy;Evoked Potentials;experience;Future;Generations;Goals;hands-on learning;Human;human subject;Implanted Electrodes;improved;indexing;Individual;Insula of Reil;Intractable Epilepsy;Iowa;Lateral;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Major Depressive Disorder;Maps;Measures;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Modality;Monitor;Moods;neurophysiology;neuropsychiatric disorder;neuroregulation;new technology;novel;novel strategies;Operative Surgical Procedures;Outcome;Parietal Lobe;Patient Care;Patients;Pattern;persistent symptom;Pharmaceutical Preparations;Physiologic pulse;Physiology;Prefrontal Cortex;Protocols documentation;Psychotherapy;Refractory;repetitive transcranial magnetic stimulation;Reproducibility;Research;Resolution;response;Rest;Scalp structure;Seizures;Site;spatiotemporal;standard measure;Stimulus;Structure;Surface;targeted biomarker;Techniques;Testing;Therapeutic;Therapeutic Uses;tool;Training;Transcranial magnetic stimulation;Treatment Efficacy;Treatment Protocols;treatment response;Universities;Work

PROJECT_TITLE: Investigating Network Plasticity Effects of Repetitive Brain Stimulation Following Invasive and Noninvasive Methods in Humans


NIH_SPENDING_CATS: Bioengineering;Cancer

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The proposed research is of high significance because it explores, at the molecular level, how brain-type creatine kinase and sphingosine kinase isoforms are regulated and released from cells to drive cancer progression and metastasis. It is relevant to public health because it will drive new therapeutic strategies for the diseases associated with their perturbed cellular distributions. Thus, the proposed research is relevant to the part of the NCI’s mission that pertains to advancing the knowledge foundation for greater understanding of the molecular basis of enzyme regulation in molecular pathways associated with cancer development and progression.

PI_NAMEs: DASTVAN, REZA  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Acidity;Acidosis;Atomic Force Microscopy;Basic Science;Binding;Binding Proteins;Biochemical;Biological Assay;Biosensor;Brain;cancer cell;Cell membrane;Cell Survival;Cells;Cellular biology;Cellular Stress;colon cancer cell line;Creatine Kinase;Cryoelectron Microscopy;Crystallography;Data;Development;dimer;Disease;Disseminated Malignant Neoplasm;Electron Spin Resonance Spectroscopy;Electrons;endosome membrane;Enzymes;extracellular;flexibility;fluorescence imaging;Foundations;Goals;Golgi Apparatus;Human;Hypoxia;Impairment;In Vitro;innovation;Knowledge;Lipids;Liposomes;Malignant Neoplasms;MAPK3 gene;Maps;Mass Spectrum Analysis;Measures;Mediating;Membrane;membrane model;Membrane Potentials;metastatic colorectal;Methodology;Methods;Mission;model organism;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;mutant;Neoplasm Metastasis;novel;novel therapeutic intervention;Organelles;Pathologic;Pathway interactions;Phosphoserine;Physiological;Process;Production;Prognosis;Protein Conformation;Protein Isoforms;Protein Kinase;Protein Secretion;protein structure;Protein translocation;Proteins;Proteolysis;Protomer;Public Health;recruit;Regulation;Research;research study;Resolution;restraint;Role;Route;Site;Solvents;Speed;sphingosine kinase;Stimulus;Structure;Testing;therapeutic target;Translational Research;tumor progression;Validation

PROJECT_TITLE: Novel molecular mechanism for extracellular release of proteins implicated in metastatic cancer

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cardiovascular;Genetics;Heart Disease;Hematology;Human Genome;Patient Safety;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Cardiotoxicity, such as heart failure, related to proteasome inhibitor carfilzomib has been an increasingly recognized adverse event for patients with multiple myeloma. We propose to identify and validate pharmacogenomic/metabolomic biomarkers for carfilzomib-related heart failure and create a predictive model to enable stratification of multiple myeloma patients in order to minimize the risk of cardiotoxicity. The proposed research is relevant to the part of NIH's mission that pertains to developing fundamental knowledge that will help reducing morbidity and mortality in the overall US population.

PI_NAMEs: GONG, YAN  (contact)

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Academic Medical Centers;Address;Adverse effects;Adverse event;Anthracycline;biobank;Biological Assay;Biological Markers;Cancer Center;Cancer Patient;cancer therapy;Cardiotoxicity;Cardiovascular system;Characteristics;Clinical;clinical practice;clinical risk;clinical translation;Data;Development;Early Diagnosis;electronic health record system;Evaluation;exome sequencing;Florida;Functional disorder;Genes;Genetic;Genetic Markers;genetic variant;Germ Lines;Goals;Heart failure;Hematology;high risk;improved;improved outcome;Incidence;insight;Intervention;Knowledge;Malignant Neoplasms;metabolomics;Mission;Morbidity - disease rate;mortality;multidisciplinary;Multiomic Data;Multiple Myeloma;multiple omics;National Heart, Lung, and Blood Institute;Oncology;Outcome;Pathway interactions;patient population;Patients;Performance;Pharmacogenomics;Population;Positioning Attribute;predictive modeling;prevent;Prevention strategy;Prospective Studies;Proteasome Inhibitor;Proteomics;Reporting;Research;Research Personnel;Risk;Risk Factors;Risk Management;risk minimization;risk prediction;risk prediction model;risk stratification;Sampling;Stratification;Symptom Burden;tool;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: A Multi-omics evaluation of Carfilzomib-related Cardiotoxicity

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: NEW YORK

ORG_DEPT: CHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative In the process of properly performing crucial biological functions—such as adhering to substrates, adhering to neighboring cells in tissues, and dividing in two—cells must generate, sense, and respond to mechanical forces. These processes also play roles in human health and disease, being utilized in the metastasizing and environmental adaptation of cancer cells, and being implicated in functions required for immune cell sensing and regulating blood flow. In this work, we are using computer simulations to predict how “mechanosensing” proteins underlying these processes change their behavior in response to applied force.

PI_NAMEs: HOCKY, GLEN  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Adopted;Behavior;behavior change;Binding Proteins;Biological Process;Blood flow;cancer cell;Cells;Computer Simulation;Disease;environmental adaptation;Health;Human;Immune;mechanical force;mechanical stimulus;Mechanics;mechanotransduction;Methodology;Molecular;Molecular Conformation;Physiological;Play;Process;Protein Conformation;Proteins;response;Role;Sampling;simulation;Techniques;Tissues;Work

PROJECT_TITLE: Harnessing simulations to uncover molecular mechanisms of mechanosensing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PUBLIC HEALTH RELEVANCE. The overall goal of this proposal is to develop a comprehensive network of disease-to-disease relationships to facilitate linking of data across broadly useful genomic and proteomic resources via the Human Disease Ontology (DO) Knowledgebase. Success of this study will address a significant barrier in data interoperability between these disparate resources. Ultimately, the DO’s large-scale integration of disease knowledge into a hierarchical classification framework will aid researchers in better understanding alternative mechanisms of disease, thus driving innovative machine learning approaches, optimizing clinical care and making disease-related data Findable, Accessible, Interoperable, and Reusable (FAIR).

PI_NAMEs: SCHRIML, LYNN MARIE (contact)

PROGRAM_OFFICER_NAME: MINEAR, MOLLIE A

PROJECT_TERMS: Acceleration;Address;Area;Artificial Intelligence;artificial intelligence method;Attention;Automobile Driving;Biological Markers;Biological Process;Biomedical Research;Classification;Clinical;clinical care;clinical training;Collaborations;Communicable Diseases;Communication;Communities;Complex;Computer Analysis;cost effective;Data;Data Aggregation;Data Analyses;Data Element;data integration;data interoperability;data management;data repository;data resource;data reuse;Data Science;Data Set;data sharing;Data Storage and Retrieval;Databases;Dental;Development;Differential Diagnosis;Discipline of Nursing;Disease;disease classification;disease model;Disparate;Encyclopedia of DNA Elements;Ensure;Environmental Risk Factor;Epigenetic Process;epigenomics;Epitopes;Etiology;FAIR principles;FlyBase;Focus Groups;Funding;Gene Expression;Genes;Genetic;Genetic Counseling;genome database;genome resource;genomic data;genomic variation;Genomics;Goals;Health;Human;human disease;Immune;improved;Informatics;Information Networks;Information Resources;Infrastructure;innovation;International;interoperability;Knowledge;knowledgebase;Laboratories;Language;Learning;Link;Machine Learning;Malignant Neoplasms;Maps;Medical;meetings;Mental Health;Mentors;Metabolic;Metadata;Methods;model organisms databases;Modeling;molecular subtypes;mouse genome;multidisciplinary;Multilingualism;National Human Genome Research Institute;Nomenclature;Ontology;open data;outreach;Pathway interactions;Pharmacy facility;Play;Positioning Attribute;precision medicine;Production;Productivity;programs;Proteomics;Protocols documentation;public health relevance;Publishing;Quality Control;rare cancer;Rare Diseases;Rat Genome Database;Regulatory Element;Research;Research Personnel;Resource Description Framework;Resources;RNA;Role;Saccharomyces;Semantics;social determinants;social factors;Standardization;statistics;Strategic Planning;success;Syndrome;Technology;Training;Triage;Update;Variant;Viral;virtual;Vocabulary;WormBase;XenBase;Zebrafish

PROJECT_TITLE: The Human Disease Ontology: An integrated, mechanistic knowledge resource for biomedical research.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: While it is established that angiotensin converting enzyme 2 (ACE2) regulates the renin- angiotensin system and thus impacts hypertension and cardiovascular disease, ACE2 also serves as the receptor for the SARS-CoV2 virus. Our application utilizes a combination of novel animal models and sophisticated analytical techniques to determine the role of ACE2 in the kidney. Understanding actions of ACE2 along the nephron is paramount to improving treatment for hypertension and reducing complications of COVID-19.

PI_NAMEs: GURLEY, SUSAN BAILEY (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: 2019-nCoV;ACE2;Acute Renal Failure with Renal Papillary Necrosis;Address;Affect;Affinity;Angiotensin II;Animal Model;Attenuated;Blood;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;blood pressure regulation;Blood Vessels;Brush Border;Cardiovascular Diseases;cell type;Cells;Coupled;COVID-19;COVID-19 complications;Data;defined contribution;Development;Disease;Endothelial Cells;Equilibrium;Excretory function;experimental study;Female;Filtration;Gene Targeting;glomerular filtration;Goals;Homeostasis;Hypertension;hypertension treatment;hypertensive;improved;Infusion procedures;Kidney;Knockout Mice;Knowledge;Length;male;Mass Spectrum Analysis;member;Membrane;Metalloproteases;Micropuncture;Modeling;Molecular;multi-photon;Mus;Mutate;nanoscale;Natriuresis;Nephrons;novel;Pathogenesis;Pathway interactions;Patients;Peptides;Persons;Phase;Phenotype;Physiological;Play;Predisposition;Proximal Kidney Tubules;receptor;Receptor, Angiotensin, Type 1;Renal function;Renin-Angiotensin System;Resistance;Role;Sampling;Serum;solute;Source;Techniques;Testing;Tissues;Transplantation;Tubular formation;urinary;Urine;Virus;Work

PROJECT_TITLE: Actions of ACE2 along with Nephron to Regulate Blood Pressure

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: Columbus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE We seek continued support for the established pre- and post-doctoral training program at The Ohio State University (OSU) in Microbe-Host Biology. This program involves 39 faculty mentors from three related life sciences graduate programs (Biomedical Sciences, Microbiology, and Veterinary Medicine) that represent the highest standards of excellence at OSU. The training program provides unique opportunities for training that integrate career-advancing components with excellence in scientific research, and the breadth and depth of our training affords awardees the capacity to make significant contributions to biomedical research in academia, government, and industry.

PI_NAMEs: DEORA, RAJENDAR K;WOZNIAK, DANIEL J (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Biology;Microbe;programs

PROJECT_TITLE: Interdisciplinary Program in Microbe-Host Biology

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Infectious Diseases;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: MOSCOW

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: Project Narrative Public misconceptions about infectious diseases are a growing threat to our nation’s ability to combat disease outbreaks. This project seeks to use innovative and compelling game-based simulations to remediate misconceptions about infectious diseases. These simulations will be part of an integrated educational program designed to build systems thinking and data literacy skills and increase the awareness of and enthusiasm for biomedical careers.

PI_NAMEs: ROBISON, BARRIE D (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: Adopted;Award;Awareness;Belief;Biology;Biomedical Research;career;Child;Cognitive;Collaborations;combat;Communicable Diseases;Complex;computer science;Computer software;Country;County;COVID-19 pandemic;Data;data literacy;Data Science;design;Development;digital tool;Disease;Disease Outbreaks;disinformation;economic disparity;Economics;Ecosystem;Education;education research;educational atmosphere;Educational Materials;Environment;Evaluation;evidence base;experience;Feedback;Florida;formal learning;Game Based Learning;game development;Goals;Health;Heterogeneity;Hispanic;Idaho;improved;Incidence;Income;Individual;infectious disease model;informal learning;innovation;Institution;instrument;interest;iterative design;Learning;literacy;Medical;Misinformation;Modeling;Molecular;multimodality;non-compliance;Nonlinear Dynamics;Participant;Pathway interactions;Pattern;Pediatric Hospitals;Persons;Predisposition;Process;programs;Property;Psyche structure;Psychological reinforcement;Public Health;Recommendation;remediation;Reproducibility;Risk;Rural;Schools;Science;science museum;Science, Technology, Engineering and Mathematics Education;science, technology, engineering, mathematics, and medicine;simulation;skills;social;Social Processes;Societal Factors;Students;System;teacher;Technology;Testing;Thinking;tool;Trust;Universities;Vaccination;Virus;Visualization

PROJECT_TITLE: Eradicating Misconceptions about Viruses using Multimodal Trace Data in an Intelligent Game-based Environment across Educational Contexts


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Immunotherapy;Lymphatic Research;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Immune checkpoint blockade is a promising class of immunotherapy for the treatment of breast cancer, in that it has the potential to both treat disseminated, metastatic disease, and protect against cancer recurrence. However, it currently only results in responses in ~15% of patients clinically. This fellowship project aims to utilize sophisticated animal models and imaging techniques to improve the interaction between antigens – molecules which label cancer cells for killing – and cognate T cells, which must be educated to respond to a specific antigen. If successful, this project will enhance the efficacy of immune checkpoint blockade and lead to better strategies to treat breast cancer clinically.

PI_NAMEs: O'MELIA, MEGHAN  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Adaptive Immune System;anergy;angiogenesis;animal imaging;Animal Model;anti-cancer;anti-tumor immune response;Antigen-Presenting Cells;Antigens;Biology;Biomedical Engineering;Blood Vessels;Breast Cancer Patient;Breast Cancer Treatment;cancer cell;Cancer Model;Cancer Patient;cancer recurrence;cancer therapy;career;Cell Communication;cell killing;Cell Proliferation;Cells;Clinical;Computer Models;Development;Disease;draining lymph node;Environment;Event;Excision;exhaustion;experimental study;Failure;Fellowship;fighting;General Hospitals;Generations;Imaging Device;Imaging Techniques;Immune;immune activation;immune checkpoint;immune checkpoint blockade;Immune response;immunoregulation;Immunotherapy;Impairment;improved;In Situ;Interruption;Intervention;intravital microscopy;Label;Laboratories;Liquid substance;Location;lymph flow;lymph nodes;Lymphatic;lymphatic circulation;Lymphatic function;lymphatic imaging;lymphatic vasculature;Lymphocyte;Lymphocyte antigen;lymphocyte trafficking;lymphoid organ;Malignant Breast Neoplasm;Malignant Neoplasms;Massachusetts;Measures;Mechanics;Mediating;medical schools;Melia;Memory;Metastatic Neoplasm to Lymph Nodes;Modeling;Molecular;Monoclonal Antibodies;Neoplasm Metastasis;novel;Patients;Phenotype;Physiological;Postdoctoral Fellow;prevent;Primary Neoplasm;Procedures;Process;Production;Recurrent disease;Research;Resected;response;Role;Source;Spatial Distribution;standard of care;stem;T cell anergy;T cell response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;tool;Training;tumor;Tumor Antigens;Tumor Biology;Tumor Immunity;tumor immunology;tumor microenvironment;Work

PROJECT_TITLE: Enhanced antigen-lymphocyte interactions to improve immune checkpoint blockade in breast cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Hematology;Lymphatic Research;Lymphoma;Rare Diseases

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because MYC dysregulation is a common feature of “high risk” diffuse large B-cell lymphoma subtypes that frequently recur after standard first-line chemotherapy. Understanding the mechanisms that lead to MYC transcriptional dysregulation in the absence of well-understood MYC-immunoglobulin gene rearrangements could lead to improved biomarkers for diagnosis of high-risk disease, and ultimately to novel therapeutic strategies for lymphoma patients.

PI_NAMEs: RYAN, RUSSELL JAMES HUBBARD (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: 8q24;Acetylation;Affect;Automobile Driving;B-Cell Activation;B-Cell Lymphomas;B-Lymphocytes;BCL6 gene;Binding;Biological Assay;Biological Markers;Biological Models;Biology;cancer type;Cell Line;Characteristics;chemotherapy;chromatin immunoprecipitation;Chromosomal Rearrangement;Complex;Credentialing;CRISPR interference;Data;Development;Diagnosis;Disease;disorder risk;Distal;Distal Enhancer Elements;DNA Sequence Rearrangement;DNA-Binding Proteins;Elements;Enhancers;Evaluation;Event;factor C;Future;Gene Activation;Gene Amplification;Gene Expression;Gene Expression Profiling;Gene Mutation;Genetic;Genetic Enhancer Element;Genetic Transcription;genomic locus;Goals;Growth;high risk;Hyperactivity;IGH@ gene cluster;Immunity;Immuno-Chemotherapy;Immunoglobulin Gene Rearrangement;Immunoglobulin Genes;improved;In Vitro;innovation;Investigation;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;Lymphoma;Lymphoma cell;Mantle Cell Lymphoma;Maps;Mature B-Lymphocyte;Mediating;Modeling;Mutation;MYC gene;myocyte-specific enhancer-binding-factor 2C;new therapeutic target;NF-kappa B;notch protein;novel;novel therapeutic intervention;Oncogene Activation;Outcome;overexpression;Pathway interactions;Patients;Population;predictive marker;promoter;Public Health;Publishing;Recurrence;Recurrent disease;Refractory;Refractory Disease;Regulation;Reporter;Repression;Research;Role;Side;Signal Transduction;Structure of germinal center of lymph node;Subgroup;Therapeutic;transcription factor;Transcriptional Activation;Work;Xenograft procedure

PROJECT_TITLE: Identifying Functional Drivers of MYC Activation via Developmental Enhancers in Diffuse Large B-cell Lymphoma

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Natural Products;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Rare Diseases;Sickle Cell Disease;Therapeutic Cannabinoid Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative: Over a third of patients with sickle cell disease use some form of cannabinoids to treat their uncontrolled pain, but there is little data to support this and little data on the adverse effects of cannabinoids in patients with sickle cell disease. However, cannabinoids have been shown to treat pain and to reduce markers of inflammation (which contributes to pain itself and to end organ damage) in other diseases of chronic pain and in mouse models of sickle cell disease. This project will study the possible efficacy study of an FDA approved cannabinoid containing product to treat pain and/or reduce inflammation in people living with sickle cell disease while also contributing to the understanding of the possible risks of this use.

PI_NAMEs: CURTIS, SUSANNA  (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Address;Adult;Adverse effects;Adverse event;Advisory Committees;Anti-Inflammatory Agents;Anxiety;Benefits and Risks;cannabinoid treatment;Cannabinoids;Cannabis;capsule;career;career development;Chemicals;chronic pain;chronic pain management;Clinical;Clinical Investigator;Clinical Research;clinical trial analysis;Clinical Trials;Clinical Trials Design;cognitive function;Controlled Study;Cross-Sectional Studies;cytokine;Data;Data Analyses;Desire for food;Development;Development Plans;Disease;Dizziness;double-masked controlled study;Dronabinol;efficacious treatment;efficacy study;Emotional;Etiology;Event;experience;FDA approved;Feasibility Studies;Fellowship;Funding;Future;Guidelines;health care service utilization;IL4 gene;IL6 gene;implementation research;improved;Incidence;Individual;Inflammation;inflammatory marker;inflammatory pain;Inhalation;Institution;Interleukin-10;K-Series Research Career Programs;Knowledge;Legal;Marijuana;marijuana use;marijuana user;Masks;Measures;Mentored Patient-Oriented Research Career Development Award;Mentorship;Modeling;monocyte;Moods;mouse model;multidisciplinary;Nausea;nerve damage;neuroinflammation;Neuropathy;neutrophil;Nociception;Opioid;opioid use;Oral;Organ;Outcome;Pain;Pain management;Pain Measurement;pain relief;painful neuropathy;Participant;Patient Self-Report;Patients;Persons;Pharmacologic Substance;Placebo Control;placebo group;Placebos;Positioning Attribute;prevent;primary outcome;Procedures;Provider;psychologic;Quality of life;Randomized;randomized trial;Reporting;Research;research and development;Research Personnel;Research Project Grants;Risk;Route;Safety;Severities;Sickle Cell Anemia;Sleep;Social Impacts;Socioeconomic Factors;Statistical Data Interpretation;statistics;Sterility;Substance P;Techniques;Terpenes;Tetrahydrocannabinol;Tissues;TNF gene;Translational Research;Tryptase

PROJECT_TITLE: Dronabinol for the reduction of chronic pain and inflammation in people with sickle cell disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Neurosciences;Sleep Research;Substance Misuse

PHR: As heavy cannabis use becomes more common in the United States, it is essential to understand the common problems associated with cannabis use, such as poor sleep, and whether targeting co-occurring problems can reduce levels of cannabis use and improve functional outcomes. Emerging data indicate that insomnia and/or use of cannabis for sleep are very common in those with problematic cannabis use. The present study will evaluate the longer-term efficacy of a Cognitive Behavioral Therapy intervention on cannabis- and sleep- related outcomes in adults with problematic cannabis use and insomnia while also studying a potential mechanism underlying the link between cannabis use and sleep.

PI_NAMEs: ARNEDT, J. TODD  (contact);ILGEN, MARK A.

PROGRAM_OFFICER_NAME: WANG, JIA BEI

PROJECT_TERMS: Adult;Aftercare;Alcohols;Cannabis;cannabis withdrawal;Chronic;Circadian Rhythms;Clinical;cognitive benefits;cognitive testing;Cognitive Therapy;Cohort Studies;Comorbid Insomnia;comorbidity;comparative efficacy;Data;Education;Electroencephalography;evidence base;follow-up;Frequencies;functional improvement;Future;Health;HIV risk;Homeostasis;Hygiene;improved;improved outcome;improvement on sleep;indexing;Individual;innovation;Intervention;Link;marijuana use;marijuana use disorder;Measures;Mediating;Medical;Medical Marijuana;medical specialties;National Institute of Drug Abuse;Neurocognitive;novel;novel strategies;Outcome;Participant;Patients;pilot trial;Polysomnography;poor sleep;Population;Prevalence;primary outcome;Process;psychosis risk;Randomized;Randomized, Controlled Trials;Recreation;recruit;REM Sleep;Reporting;Respondent;Risk;Risk Behaviors;Sampling;Sleep;sleep abnormalities;Sleep Architecture;Sleep Disorders;Sleeplessness;Slow-Wave Sleep;substance use;Substance Use Disorder;substance use treatment;success;symptom management;Symptoms;System;Telemedicine;Testing;Therapeutic Intervention;Time;United States;Withdrawal;Work

PROJECT_TITLE: Targeting insomnia to improve outcomes in adults with problematic cannabis use

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Diabetes is a major world health problem, with severe complications. Unique animal models of hyperinsulinism and diabetes due to altered electrical activity in the pancreas reiterate complications seen in human disease. Proposed experiments will use these animals to determine mechanisms of disease complications and thereby help development of appropriate therapies for human hyperinsulinism and diabetes.

PI_NAMEs: NICHOLS, COLIN G (contact);REMEDI, MARIA SARA

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Acute;Address;Animal Model;Animals;Beta Cell;Biological;blind;Calcium;Cations;Cells;Chronic;Climacteric;clinically significant;Collaborations;Coupling;Data;db/db mouse;density;Development;Diabetes Mellitus;Diazoxide;Disease;Down-Regulation;Electrophysiology (science);Exhibits;experimental study;Exposure to;Failure;Feedback;gain of function mutation;Gene Expression;genetic approach;Glucose;Glucose Intolerance;glucose tolerance;Goals;High Fat Diet;Human;human disease;Hyperglycemia;Hyperinsulinism;improved;Individual;inhibitor;Insulin;Insulin Resistance;insulin secretion;Ions;islet;Joints;knock-down;Knockout Mice;Link;loss of function;Measures;Modeling;Molecular;mouse model;Mus;Mutation;neonatal diabetes mellitus;Non-Insulin-Dependent Diabetes Mellitus;novel;Pancreas;Patients;Persistent Hyperinsulinemia Hypoglycemia of Infancy;pharmacologic;Physiological;Process;Productivity;Publishing;response;Role;Secretory Cell;Stress;Structure of beta Cell of islet;Sulfonylurea Compounds;Testing;therapeutic development;Time;transcriptomics;TRPM5 gene;World Health

PROJECT_TITLE: KATP deficiency in hyperinsulinism and diabetes

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Diabetes;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Fine-tuned regulation of insulin secretion by pancreatic islet beta cells in response to environmental signals is critical for human health and survival. Our proposal will apply systematic, single cell-resolved multiomic data collection in human pluripotent stem cell-derived islet organoids exposed to secretory signals to predict and validate network-level relationships among genomic elements, genes, and insulin secretion phenotypes.

PI_NAMEs: CARTER, HANNAH KATHRYN (contact);GAULTON, KYLE JEFFRIE;REN, BING ;SANDER, MAIKE

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;Affect;Alleles;Amino Acids;Architecture;Beta Cell;Biological;Biological Assay;Biology;Blood Glucose;blood glucose regulation;Catalogs;Cell model;Cell Nucleus;cell type;Cells;Cellular Assay;Characteristics;Chromatin;Chromatin Remodeling Factor;Collaborations;combinatorial;Communities;Computer Models;CRISPR interference;cytokine;Data;Data Collection;Development;diabetes risk;Disease;DNA Methylation;Elements;Environment;Epigenetic Process;epigenomics;experience;Exposure to;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene network;gene regulatory network;Genes;Genetic;genetic variant;Genome engineering;genome-wide;genomic data;genomic variation;Genomics;Glucocorticoids;Glucose;Gonadal Steroid Hormones;Health;Hormones;Hour;Human;human pluripotent stem cell;Individual;Inflammatory;innovation;innovative technologies;Insulin;insulin regulation;insulin secretion;islet;islet stem cells;Islets of Langerhans;Link;Lipids;Machine Learning;Maps;Measures;Mediating;Methods;model building;Modeling;multidisciplinary;Multiomic Data;multiple omics;network models;Network-based;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Organoids;Output;Pancreas;pancreatic juice;Phenotype;Process;Production;programs;Regulation;Regulator Genes;Regulatory Element;Research Personnel;response;RNA;Signal Induction;Signal Transduction;single cell genomics;stem cells;Structure of beta Cell of islet;Study models;System;Testing;Time;Training;transcription factor;Untranslated RNA;Variant

PROJECT_TITLE: The impact of genomic variation on environment-induced changes in pancreatic beta cell states


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Precision Medicine;Women's Health Research

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE Of to de-escalating invasive tomography   neoadjuvant therapy (NAT). These outcomes result in a decrease in cancer burden by improving prognosis, surgery, and enabling response-driven precision medicine. To address the need for reliable, non- imaging method to identify response, prototypes into one system. critical importance to improving outcomes for breast cancer patients is identifying who responds we propose to integrate two photoacoustic computed

PI_NAMEs: LAI, LILY LAU (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: 3-Dimensional;Acoustics;Address;Algorithms;anatomic imaging;Anatomy;Anxiety;Arteries;Biopsy;Blood Vessels;Brain;Brain imaging;Breast;Breast Cancer Detection;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;Breast conservation;breast imaging;Calibration;Cancer Burden;Cities;Clinical;contrast enhanced;Contrast Media;cost;cost effective;Data;density;design;Detection;Diagnostic;diffuse optical spectroscopy and imaging;Dimensions;Discrimination;Elasticity;Emerging Technologies;Engineering;Evaluation;exceptional responders;experience;Feasibility Studies;Frequencies;Functional Imaging;Heavy Metals;Hemoglobin;Human;Image;imaging modality;Imaging problem;imaging system;Imaging Techniques;Imaging technology;improved;improved outcome;innovation;Intravenous;Ionizing radiation;Light;Lilium;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Metabolic;Methods;model building;Modeling;Morphologic artifacts;Morphology;Motion;Neoadjuvant Therapy;new technology;non-invasive imaging;Operative Surgical Procedures;Optics;optoacoustic tomography;Outcome;Oxygen;Pathology;patient oriented;Patients;Performance;performance tests;personalized cancer therapy;photoacoustic imaging;Physicians;precision medicine;predicting response;Prognosis;prognostic;prospective;prototype;research clinical testing;Resected;Resolution;Resources;respiratory;response;Sampling;Scientist;Side;Signal Transduction;Specimen;Speed;standard of care;success;Surgical Pathology;System;Technology;Testing;Three-Dimensional Imaging;Time;Tissues;tomography;Training;treatment planning;treatment response;tumor;Tumor Volume;Ultrasonography;X-Ray Computed Tomography

PROJECT_TITLE: Advancing Photoacoustic Tomography in breast imaging to predict response in breast cancers treated with neoadjuvant therapy

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]