NIH_SPENDING_CATS: Diabetes

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Dysfunction and death of the insulin-producing β-cell underlies virtually all forms of diabetes, and the protection of β-cells represents an approach to the treatment of diabetes that has yet to be exploited. The 12-LOX pathway represents an attractive target for protection of β-cells, since inhibitors of this pathway have been developed. This proposal will provide a better understanding of how the 12-LOX pathway can be manipulated to protect β-cells.

PI_NAMEs: KULKARNI, ROHIT N.;MIRMIRA, RAGHAVENDRA G (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Abdomen;acid stress;Acids;Active Sites;Adverse effects;Affinity;Applications Grants;Arachidonate 12-Lipoxygenase;Award;Beta Cell;Biology;Cell Line;Cell Physiology;Cells;Cessation of life;Characteristics;Chemicals;Collaborations;conditional knockout;Diabetes Mellitus;Eicosanoids;endoplasmic reticulum stress;Enzymes;Exhibits;expectation;Family;Functional disorder;Funding;G-Protein-Coupled Receptors;Gene Deletion;Genes;Genetic Models;GPR31 receptor;Growth Factor;Human;Human Biology;humanized mouse;Image;Imaging Device;impaired glucose tolerance;in vivo;in vivo Model;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;innovation;insight;Insulin;Insulin Resistance;insulin signaling;Intervention;intravital imaging;islet;Knock-in Mouse;Knock-out;Knockout Mice;Link;Lipids;Lipoxygenase;Mediating;Modeling;Molecular;mouse model;Mus;novel;Obesity;Oxidative Stress;Paper;Pathway interactions;Phase;Polyunsaturated Fatty Acids;pre-clinical;Productivity;Protein Isoforms;Publications;Reagent;receptor;receptor-mediated signaling;release of sequestered calcium ion into cytoplasm;Research Personnel;Role;Signal Transduction;Small Business Technology Transfer Research;System;Testing;Therapeutic;therapeutic target;Time;tool;two-photon;type I and type II diabetes;Validation;virtual;Work

PROJECT_TITLE: Role of 12-lipoxygenase and 12-HETE signaling in beta-cell dysfunction

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Diffuse midline gliomas (DMG)-H3K27 altered represent the leading cause of glioma-related deaths in children and adolescents currently without effective treatment options. In this proposal, we are seeking conceptual advances on gene regulation and tumorigenesis of DMG and discovering novel drug targets for this deadly disease.

PI_NAMEs: ZHANG, ZHIGUO  (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: Acetylation;ACVR1 gene;Adolescent;Amino Acids;ATPase Domain;axon guidance;Catalytic Domain;Cell Communication;Cell Proliferation;Cells;Cessation of life;chemotherapy;Child;Chromatin;Complex;CRISPR screen;Data;Dependence;Development;Diagnosis;Diffuse intrinsic pontine glioma;diffuse midline glioma;Disease;DNA Sequence Alteration;driver mutation;effective therapy;EP300 gene;Ephrins;Epigenetic Process;Event;Excision;EZH2 gene;Family;fitness;FOSL1 gene;Functional disorder;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Silencing;Genes;Genetic Transcription;Glioma;Heterozygote;Histone H3;histone modification;Impairment;In Vitro;in vivo;Invaded;Link;Lysine;Malignant Childhood Neoplasm;Malignant Neoplasms;member;Methionine;Methylation;migration;Molecular;mouse model;mutant;Mutation;neoplastic cell;Nervous System Disorder;neurogenesis;Neurologic;neuronal tumor;Neurons;Neurosciences;new therapeutic target;novel;Nucleosomes;oncohistone;Operative Surgical Procedures;p300/CBP-Associated Factor;Pathogenesis;Pathogenicity;patient derived xenograft model;Phenotype;Prognosis;Proliferating;protein H(3);Proteins;Radiation therapy;Receptor Protein-Tyrosine Kinases;recruit;Regulation;Regulatory Element;Resistance;Role;Signal Transduction;Somatic Mutation;Subgroup;Syndrome;Testing;therapeutic target;transcription factor;treatment response;tumor;tumor growth;tumor progression;tumorigenesis;Variant

PROJECT_TITLE: Roles of Chromatin Remodeler CHD2 in Diffuse Midline Glioma with Onco-Histone Mutations

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Prevention

ORG_CITY: COLLEGE PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: The University of Maryland School of Public Health proposes to continue a Summer Training and Research (STAR) program for yrs 11-15 that provides underrepresented and disadvantaged undergraduate students with two consecutive 10-wk summers of research and career development training to enhance their potential to apply for and complete graduate degrees in biomedical and behavioral science relevant to preventing and treating cardiovascular disease. The aim of the STAR program is to increase diversity in the pool of individuals who ultimately choose careers in biomedical and behavioral research to reduce premature morbidity and mortality from cardiovascular, lung, and blood diseases. STAR Trainees primarily focus on laboratory research closely integrated with that of their faculty Mentor; in addition, Trainees meet weekly to discuss research issues, set weekly goals, meet with various academic professionals for dynamic exchanges about graduate school issues, discuss classic research articles on cardiovascular disease, and take part in either Ethics- Related (first year trainees) or Research-Related (second year trainees) Training.

PI_NAMEs: HAGBERG, JAMES M (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Address;Admission activity;Affect;African American;African American population;Age;Area;Awareness;Bachelor's Degree;Behavioral Research;Behavioral Sciences;Benchmarking;Biomedical Research;Blood;Blood Pressure;burden of illness;Cardiovascular Diseases;Cardiovascular system;career;career development;Cessation of life;Communities;community based participatory research;Data;design;Disadvantaged;Discipline;Disparity;Disparity population;Doctor's Degree;Education;Education Projects;education research;Educational Status;Environment;Ethics;ethnic diversity;Ethnic Population;experience;Faculty;faculty mentor;Feedback;Funding;Goals;Graduate Degree;graduate school;Graduation Rates;Health;Health Disparities Research;health disparity;health goals;Healthy People 2020;Hematological Disease;Housing;Hypertension;improved;Income;Individual;Knowledge;Laboratories;Laboratory Research;Latino;Life;Life Experience;Lung Diseases;Maryland;Measures;Mentors;Minority;Minority Groups;Mission;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Obesity;Oral;Outcome;Overweight;Population;posters;premature;Prevalence;prevent;Prevention;Process;Production;Program Development;Program Evaluation;programs;Public Health;Public Health Schools;racial diversity;racial population;Recommendation;recruit;Remunerations;Reporting;Research;Research Activity;research and development;Research Personnel;Scholarship;Science;Scientist;skills;social;Strategic Planning;Students;Subgroup;success;summer program;summer research;Time;Training;Training Programs;Trust;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;virtual;Visit;Washington;web site;Work

PROJECT_TITLE: University of Maryland Summer Training and Research (STAR) Program


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: RELEVANCE: Given the disproportionate burden of cardiovascular disease in rural areas, particularly in the southeastern portion of the United States, the proposed study will examine whether features of neighborhood physical and social environments are associated with CVD risk and subclinical disease burden in rural communities, and which groups are most vulnerable and resilient to the health impacts of these environments. Findings from this research may help to elucidate the key contextual drivers of cardiovascular risk and resilience in rural communities.

PI_NAMEs: MUJAHID, MAHASIN S (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Age;Appalachian Region;arterial stiffness;built environment;burden of illness;Businesses;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;cohort;coping;coronary artery calcification;Country;County;COVID-19 burden;COVID-19 morbidity;COVID-19 mortality;Crime;Cross-Sectional Studies;Data;Data Sources;Databases;Diabetes Mellitus;Disease;Disease Outcome;Doctor of Philosophy;early childhood;Environment;ethnic disparity;Ethnic Origin;experience;Food Access;Funding;Future;Gender;Geography;Goals;Health;Health Food;Health Promotion;healthy lifestyle;High Prevalence;Home;improved;Individual;Intervention;Investigation;Knowledge;Life;Link;Longitudinal Studies;Measures;Mental Depression;Mississippi;Morbidity - disease rate;mortality;neighborhood disadvantage;Neighborhoods;novel;Obesity;optimism;Outcome Study;pediatric trauma;Physical environment;physical inactivity;Population;Predisposition;Principal Investigator;programs;psychologic;psychosocial;Race;racial disparity;racial diversity;recruit;Research;residence;resilience;Risk;Risk Factors;Role;Rural;rural area;Rural Community;rural counties;Rural Health;Rural Population;Safety;sex;social;Social Characteristics;social cohesion;Social Environment;Social Interaction;Social Network;Social support;socioeconomics;Source;Subgroup;Surveys;Typology;United States;urban dwelling;virtual;Well in self;Work

PROJECT_TITLE: Neighborhoods and Cardiovascular Risk and Resilience in Rural Communities

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Nutrition;Obesity

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Obesity and the associated type 2 diabetes are major public health problems. Understanding how TMEM135 regulates mitochondrial dynamics and brown fat-mediated thermogenesis could uncover a novel option for treating these metabolic disorders.

PI_NAMEs: LODHI, IRFAN J (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Adipocytes;Adipose tissue;Adrenergic Agents;ATP Synthesis Pathway;Biogenesis;Brown Fat;constriction;CRISPR/Cas technology;Data;Defect;diet-induced obesity;Dietary Supplementation;effective therapy;Endoplasmic Reticulum;Energy Metabolism;Ethers;Fatty acid glycerol esters;Homeostasis;Image;Impairment;innovation;knock-down;Knock-out;Link;lipid metabolism;Lipids;LoxP-flanked allele;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic Diseases;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial membrane;Mitochondrial Membrane Protein;Molecular;Morphology;Mus;Non-Insulin-Dependent Diabetes Mellitus;Norepinephrine;novel;Obesity;obesity treatment;OPA1 gene;Organelles;overexpression;Oxygen Consumption;peroxisome;Phospholipids;Phosphorylation;Plasmalogens;Play;Proteins;Public Health;Publishing;recruit;Regulation;Respiration;response;Role;Shapes;Site;superresolution microscopy;Supplementation;Surface;targeted treatment;Testing;Therapeutic;Thermogenesis;Tissues;Transgenic Mice;Tubular formation;uncoupling protein 1;Work

PROJECT_TITLE: Mitochondrial dynamics and the control of adipose tissue thermogenesis

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ORG_CITY: FARMINGTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Heart failure is a syndrome of major public health significance. An estimated 6.2 million Americans are currently suffering from heart failure, and this number is estimated to increase 46% by 2030. A better understanding of the molecular mechanism underlying cardiac remodeling, including pathological myocyte hypertrophy, should significantly help in the design of new therapeutics for treatment, thereby decreasing patient mortality.

PI_NAMEs: DODGE-KAFKA, KIMBERLY L (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: A kinase anchoring protein;Adrenergic Receptor;Adult;Affect;American;Attenuated;beta-adrenergic receptor;Binding;Binding Proteins;Buffers;Calcineurin;calcineurin phosphatase;Calmodulin;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Catecholamines;cell growth;Cell Nucleus;Cells;Chronic stress;Coupling;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Dedications;Dependovirus;design;Disease;experimental study;fighting;Gene Expression;gene induction;Genetic Transcription;Heart;Heart Diseases;Heart failure;Heart Hypertrophy;Hypertrophy;In Vitro;in vivo;Individual;Induced Cardiomyocytes;Infusion procedures;inhibitor;Mediating;Membrane;Modeling;Molecular;mortality;Muscle;Muscle Cells;Muscle Proteins;nanobodies;Norepinephrine;novel;novel strategies;novel therapeutics;Nuclear;Nuclear Envelope;nuclear factors of activated T-cells;Pathologic;Pathway interactions;Patients;pharmacologic;Phosphotransferases;Physiological;pressure;prevent;Prevention;Prevention strategy;Production;protein B;Proteins;Public Health;Publishing;Rattus;Reagent;receptor;Receptor Activation;receptor internalization;Receptor Signaling;Recombinants;Regulation;response;Sarcoplasmic Reticulum;scaffold;Scaffolding Protein;Second Messenger Systems;side effect;Signal Induction;Signal Transduction;Small Interfering RNA;Specificity;Syndrome;Testing;Therapeutic;therapeutically effective;tool;transcription factor;Ventricular;Work

PROJECT_TITLE: Perinuclear Signaling and Cardiac Hypertrophy

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: Aurora

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative This training program recruits 6 undergraduate diversity students for research experiences and mentorship in environmental health sciences for one year and will include an intensive summer program focusing on laboratory experiences, mentoring, responsible conduct of research training and educational/inspirational experiences. Students will gain a better understanding of future career options and how to prepare for graduate or professional school with a long-range goal of increasing the number and quality of diversity students pursuing a career path in basic, translational or clinical environmental health sciences research.

PI_NAMEs: BAUER, ALISON K;BROWN, JARED MICHAEL (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: base;Basic Science;Biological Sciences;Biology;career;Career Choice;career development;Chemistry;Clinical;Clinical Research;Colorado;Communities;Community Developments;Data Analyses;Development Plans;disadvantaged student;Education;Educational process of instructing;Educational workshop;Environment;Environmental Health;Environmental Science;experience;Exposure to;Faculty;faculty mentor;First Generation College Students;Foundations;Funding;Future;Goals;Graduate Education;graduate school;hands on research;Health;health science research;Human;improved;interest;laboratory experience;Manuscripts;Measures;Medical;meetings;Mentors;Mentorship;Minority Groups;National Institute of Environmental Health Sciences;Outcome;Participant;programs;Public Health;Publications;Publishing;Readiness;Recording of previous events;recruit;Research;Research Project Grants;Research Technics;Research Training;responsible research conduct;Schools;Science;Series;skill acquisition;social;Structure;Student recruitment;Students;success;summer program;symposium;Toxicology;Training;Training and Education;Training Programs;Translational Research;undergraduate research;undergraduate student;underrepresented minority student;Underrepresented Students;underserved students;Universities;university student;Work;Writing

PROJECT_TITLE: Colorado Undergraduate Research in Environmental Health Science


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Genetics;Human Genome;Lung;Machine Learning and Artificial Intelligence;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Early identification of individuals at high risk for chronic obstructive pulmonary disease (COPD) has been partially addressed by genetic risk scores and gene expression prediction models, though these tools are suboptimal in non-Europeans. We propose developing a multi-ancestry genetic and blood- and lung-based gene expression risk scores. We will use these risk scores to classify individuals and identify drugs for COPD.

PI_NAMEs: MOLL, MATTHEW R (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Acute;Address;Adrenal Cortex Hormones;African American population;African ancestry;Age;Binding;biobank;Blood;Blood specimen;candidate identification;career development;Chronic Obstructive Pulmonary Disease;cigarette smoking;Classification;Clinical;clinical practice;clinical risk;cohort;Data;Databases;Detection;Development;Development Plans;Disease;disease heterogeneity;disease phenotype;Disease susceptibility;disorder risk;disorder subtype;drug candidate;drug repurposing;Early identification;European;European ancestry;Future;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;Genetic;genetic architecture;genetic association;genetic epidemiology;genetic predictors;Genetic Risk;Genetic Transcription;genetic variant;genome wide association study;Genomic Segment;Glass;Heterogeneity;high risk;improved;Individual;Inhalation;insight;Intervention;Learning;learning network;Lung;lung basal segment;Machine Learning;machine learning method;Maps;Measures;mortality;multiple omics;Odds Ratio;Outcome;Participant;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Performance;personalized intervention;Pharmaceutical Preparations;Phenotype;polygenic risk score;Population;predictive modeling;Predictive Value;Predisposition;progression risk;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Regulatory Pathway;Research;research and development;Research Personnel;respiratory;Risk;Risk Factors;risk prediction;risk stratification;Sample Size;Sampling;Smoking;Smoking History;Spirometry;Structure of parenchyma of lung;Subgroup;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissue Sample;tool;Training;Transcript;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Variant;Whole Blood

PROJECT_TITLE: Multi-omic Risk Prediction of Chronic Obstructive Pulmonary Disease in European- and African-Ancestry Populations

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Hematology;Infant Mortality;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Sepsis

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE: The proposed research is relevant to public health because necrotizing enterocolitis (NEC) affects 7% of infants hospitalized in neonatal intensive care units and is a leading cause of neonatal sepsis. Prevention and treatment strategies are currently lacking. This project is relevant to the NIH’s mission because it will define the mechanistic response of the intestinal epithelium during NEC, developing fundamental knowledge that will help reduce the burden and mortality of this human disease.

PI_NAMEs: HUNTER, CATHERINE JANE (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: 12 year old;Accounting;Actins;Affect;Agonist;Apoptosis;Attenuated;Cause of Death;caveolin 1;Cell Death;Cell Physiology;Cessation of life;Clinical;Cyclic AMP-Dependent Protein Kinases;cytokine;Cytoskeleton;Data;defined contribution;Development;Disease;E-Cadherin;Early Intervention;Endocytosis;Enterocytes;Epithelial Cells;Epithelium;Event;Excision;Experimental Models;feeding;Functional disorder;Future;Gene Modified;genetic approach;Gestational Age;Health;Homeostasis;Hospitalization;Human;human disease;human mortality;Immune;Impairment;improved;in vivo;in vivo evaluation;Infant;Inflammation;Inflammatory;Injury;insight;Intercellular Junctions;Intervention;intestinal barrier;Intestinal Diseases;intestinal epithelium;Intestines;Knockout Mice;Knowledge;Mediating;Medical;microbial;microbial colonization;Mission;Molecular;Mucositis;Mucous Membrane;Mus;Necrotizing Enterocolitis;Neonatal;Neonatal Intensive Care Units;Neonatal Mortality;neonatal sepsis;Newborn Infant;occludin;Organ;Organoids;Outcome;Pathogenesis;Pathway interactions;Patient Admission;Patients;Pattern;Permeability;pharmacologic;Predisposition;premature;Premature Infant;prevent;Prevention strategy;Process;protein expression;protein function;Protein Kinase;Protein-Serine-Threonine Kinases;Proteins;Public Health;Regulation;repaired;Research;response;restoration;rho;Rho-associated kinase;Sampling;Sepsis;Signal Transduction;Specimen;systemic inflammatory response;targeted treatment;Testing;Therapeutic Intervention;therapeutically effective;therapy development;Tight Junctions;Tissues;translational potential;treatment strategy;United States National Institutes of Health;Work

PROJECT_TITLE: ROCK, tight junctions and prematurity in the pathogenesis of necrotizing enterocolitis and neonatal sepsis.

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: NARRATIVE Defining how T and B cell populations are improperly generated during autoimmunity will have functional consequences in progression of disease and disease enhancing antibodies. This study explores development of these cells at different stages of disease and may provide new targets for future therapeutics in autoimmunity.

PI_NAMEs: WEINSTEIN, JASON  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Acute;Affect;Aging;Agonist;Antibodies;Architecture;Autoantibodies;Autoimmune Diseases;Autoimmunity;Automobile Driving;B cell differentiation;B-Cell Activation;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;Blood;CD4 Positive T Lymphocytes;Cell Communication;Cell Maturation;Cell secretion;Cells;Chromatin;Chronic;Clinical;cytokine;Data;design;Development;Disease;Disease Progression;Future;Generations;Genetic;Genetic Transcription;Genomic approach;Goals;Helper-Inducer T-Lymphocyte;Human;Immunoglobulin Class Switching;Immunoglobulin Isotypes;Immunoglobulin Somatic Hypermutation;Immunoglobulin-Secreting Cells;Inflammation;Inflammatory;inflammatory milieu;insight;Interferon alpha;Interferon Type II;interleukin-21;ITGAX gene;Kidney;Kinetics;Liver;Lupus;lupus prone mice;Memory B-Lymphocyte;Molecular;Mus;novel;novel therapeutics;pathogen;pathogenic autoantibodies;Pathogenicity;Pathway interactions;Patients;Plasma Cells;Population;Production;Reaction;Regulation;Reporter;response;Rheumatoid Arthritis;Role;secondary lymphoid organ;Signal Transduction;Site;SLEB1 gene;Somatic Mutation;Spleen;Splenectomy;Structure of germinal center of lymph node;systemic autoimmune disease;systemic autoimmunity;Systemic Lupus Erythematosus;T cell regulation;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Techniques;Therapeutic;tissue injury;Tissues;Transcriptional Regulation;Transgenic Organisms;Viral;Virus Diseases;Work

PROJECT_TITLE: T cell regulation of pathogenic B cells in systemic autoimmunity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative  There is currently no ideal therapy for type II diabetes (TIID), the most prevalent type of diabetes, which doubles a patient’s risk for cardiovascular disease (CVD) and death due to CVD. In this proposal, we will examine the molecular mechanisms by which a high fat diet induces insulin resistance in the heart, as obesity is thought to be its main cause. This information will allow for the development of new and effective therapies to prevent CVD in patients with TIID.

PI_NAMEs: PFLEGER KARCH, JESSICA  (contact)

PROJECT_TERMS: Autophagocytosis;Binding;Blood Glucose;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular disorder risk;Cell Respiration;Cessation of life;Chemicals;Chromatin;chromatin immunoprecipitation;Complex;Consensus;Coronary Arteriosclerosis;Critical Pathways;Data;Data Set;deep sequencing;Development;Diabetes Mellitus;diabetic cardiomyopathy;Diet;DNA Binding Domain;DNA Damage;Dyslipidemias;effective therapy;Fatty acid glycerol esters;Fatty Acids;Gene Expression;Genes;Genetic;Genetic Transcription;genome-wide;genomic locus;Heart;Heart failure;High Fat Diet;Hypertension;Impairment;In Vitro;in vivo;inhibitor;Insulin;insulin regulation;Insulin Resistance;insulin sensitivity;insulin sensitivity/resistance;insulin signaling;Investigation;Mediating;Mediator;Messenger RNA;Metabolic;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Myocardial dysfunction;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nuclear;Obesity;Pathogenesis;Pathway interactions;Patient risk;Patients;Polymerase;prevent;protein expression;Proteins;Resistance;Risk Factors;RNA Polymerase II;Role;Signal Transduction;Testing;Transcription Initiation Site;Transcriptional Regulation;Up-Regulation

PROJECT_TITLE: The role of REDD1 in insulin-mediated transcription

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE The experiments will test what changes occur in the prefrontal cortex after subjects are trained to perform a cognitive task that requires visual, short-term memory. Such training has shown promise in improving cognitive function after traumatic brain injury, stroke, and normal aging. Our results will uncover the changes in brain circuits following cognitive training and offer insights on the design of better treatment strategies for these conditions.

PI_NAMEs: CONSTANTINIDIS, CHRISTOS  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;adjudication;Age-associated memory impairment;Animals;Anterior;Area;Basic Science;Behavior;Behavioral;Brain;Chronic;cingulate cortex;Cognitive deficits;cognitive function;Cognitive remediation;cognitive task;cognitive training;Communication;Complex;Computer Models;design;Detection;Educational Intervention;Electrodes;Exclusion;experimental study;extrastriate visual cortex;Implant;improved;insight;Intelligence;Intervention;Knowledge;Language;Learning;Link;Liquid substance;Location;Maintenance;member;Memory;Mental disorders;Microelectrodes;Modeling;Monitor;Monkeys;Nature;neural;neural circuit;neural correlate;neuromechanism;neuronal patterning;Neurons;neurophysiology;nonhuman primate;normal aging;Performance;Periodicity;Play;Population;Prefrontal Cortex;Psychological Transfer;recruit;Resolution;Role;Sampling;Scheme;Sensory;Shapes;Short-Term Memory;Signal Transduction;Site;Stimulus;Stroke;Structure;Task Performances;Testing;theories;Training;Traumatic Brain Injury;treatment strategy;Visit;Visual;visual information;Visuospatial;Work

PROJECT_TITLE: Neurophysiological Effects of Training in Visual Cognitive Tasks

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative Experience-dependent neural network refinement is a fundamental process during postnatal brain development. This project is to investigate the molecular mechanisms that underlies silent synapse-based cortical excitatory network refinement. Specifically, we aim to dissect a signaling hub, coordinated by the signaling scaffold PSD- 95 that controls the pace of silent synapse maturation local visual cortex circuits and visual perception.

PI_NAMEs: HAAS, WILHELM ;SCHLUETER, OLIVER  (contact);XU, WEIFENG

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Affect;AMPA Receptors;Architecture;area striata;Automobile Driving;Biological Assay;Brain;cell type;Complex;conditional knockout;confocal imaging;Corpus striatum structure;critical developmental period;critical period;density;Development;DLG4 gene;Electrophysiology (science);Equilibrium;Event;experience;experimental study;Genetic Epistasis;genetic manipulation;Glutamates;Hippocampus;Impairment;in vivo;inhibitor;Knockout Mice;Learning;Ligase;Link;Mediating;Modeling;Molecular;Morphology;mouse model;Mus;mutant;N-Methyl-D-Aspartate Receptors;neural circuit;neural network;neuromechanism;Neurons;novel;Outcome;Pathway interactions;Pattern;Peptides;Perception;phosphoproteomics;Phosphorylation;postnatal;postsynaptic;Procedures;Process;Property;Protein Dephosphorylation;Protein Tyrosine Phosphatase;Proteins;Proteome;Proteomics;Proxy;recruit;Reporting;Role;scaffold;Sensory;Signal Pathway;Signal Transduction;Slice;src-Family Kinases;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;tool;Transduction Gene;Transgenic Mice;Tyrosine;Tyrosine Phosphorylation;Vertebral column;Viral Vector;Vision;Visual;Visual Cortex;Visual Perception

PROJECT_TITLE: Mechanisms of Silent Synapse Maturation for Excitatory Network Refinement

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Women's Health Research

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: NARRATIVE Black and Hispanic women of childbearing age are at risk for alterations in sleep health that contribute to significant health outcomes, including adverse pregnancy outcomes, cardiometabolic and psychological health. We will conduct a comprehensive evaluation of multi-dimensional aspects of sleep health and determine the associations between potentially modifiable sleep-related cognitions and behaviors and sleep health and the extent to which cognitions and behaviors moderate the relationships between social and environmental determinants and sleep health. The results will be used to inform future intervention to promote sleep health, reduce sleep deficiency, and improve sleep-related outcomes among these women.

PI_NAMEs: REDEKER, NANCY S (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Acculturation;actigraphy;adverse pregnancy outcome;Age;Age Reporting;alertness;Behavior;Behavioral;behavioral sleep intervention;Belief;Birth;black women;cardiometabolism;Characteristics;Chronic;circadian biology;Cognition;Cognitive;Communities;community engaged approach;community engagement;Country;Death Rate;Diabetes Mellitus;Dimensions;Ensure;Environmental Risk Factor;ethnic identity;Ethnic Origin;Ethnic Population;Evaluation;Family;Female of child bearing age;Foundations;Future;Health;health disparity;Hispanic Women;Home;Hour;Hypertension;improvement on sleep;Income;indexing;Individual;Intervention;Interview;maternal morbidity;Maternal Mortality;Mental Health;Mental Health Services;Methods;mindfulness;modifiable risk;Morbidity - disease rate;mortality;multi-ethnic;Neighborhoods;Obstructive Sleep Apnea;Outcome;Patient Self-Report;Perception;Phenotype;Policies;Polysomnography;poor sleep;preference;Pregnancy;Pregnancy Rate;protective factors;racial population;racism;Recommendation;Relaxation;Research;resilience;Restless Legs Syndrome;Risk;Risk Factors;Role;Sampling;satisfaction;Sleep;Sleep Apnea Syndromes;sleep behavior;Sleep Deprivation;Sleep Disorders;Sleep Fragmentations;sleep health;sleep pattern;sleep quality;Sleeplessness;social;social factors;social influence;Structure;Symptoms;United States National Institutes of Health;Variant;Voice;Wakefulness;Well in self;Woman;Women's Health;women's outcomes;Work

PROJECT_TITLE: Phenotypes of Sleep Health among Black and Hispanic Women of Childbearing Age

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Orphan Drug;Rare Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: RELEVANCE: In this MPI R01, we propose to develop and validate a Radiomic Tumor Response (RadTR) classifier that will leverage routine MRI scans to proactively identify rectal cancer patients who will achieve complete response after neoadjuvant therapy so they can be safely recommended organ-preserving management; with the ultimate goal of improving patient outcomes and disease-free survival in rectal cancers.

PI_NAMEs: PURYSKO, ANDREI SARAIVA;STEINHAGEN, EMILY ;VISWANATH, SATISH EASWAR (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: Adjuvant Chemotherapy;Aftercare;age group;Agreement;Asian;Benchmarking;Biological;Biology;Black race;blood-based biomarker;Cancer Patient;Carcinoembryonic Antigen;Caucasians;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Clinical;Clinical Trials;clinically actionable;cohort;Collagen;Computers;cost;Cues;Data;Descriptor;design;Desmoplastic;detection sensitivity;Development;Diagnosis;Diagnostic;diagnostic criteria;digital;Disease-Free Survival;Endoscopy;Ensure;Environment;Equity;Evaluation;Excision;experience;Extravasation;Fatty acid glycerol esters;Fecal Incontinence;Fibrosis;Future;Goals;Heterogeneity;Histopathology;Image;imaging biomarker;Immune response;improved;In complete remission;in vivo;Inflammatory;Injury;innovation;Institution;interest;Lesion;Magnetic Resonance Imaging;Maps;Measurement;model development;Modeling;Morphology;morphometry;MRI Scans;Myofibroblast;Neoadjuvant Therapy;neoplastic cell;non-invasive imaging;novel;Operative Surgical Procedures;Organ Preservation;Ostomy;Pathologic;Pathology;patient response;Patient-Focused Outcomes;Patients;Pelvis;Performance;personalized management;Population;Quality of life;racial population;radiomics;Reaction;Reader;Recommendation;Rectal Cancer;Rectal Neoplasms;Rectum;Reproducibility;research clinical testing;response;Sepsis;Serum;sex;Specificity;Specimen;Structure;success;Survival Rate;Tissues;treatment effect;treatment response;treatment strategy;tumor;Validation;Visualization

PROJECT_TITLE: Novel radiomic signatures for treatment response to neoadjuvant therapy in rectal cancers

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STONY BROOK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: NARRATIVE The central hypothesis of this proposal is that the muscle stem cell niche is an everchanging environment in which proteases play an important role by cleaving and activating, or neutralizing, signaling molecules, their receptors, and the extracellular matrix. Our three specific aims are to define how the muscle stem cell niche is remodeled in the early hours and days after injury by the activity of neutrophil serine proteases. We will identify the cellular and molecular mechanisms regulated by neutrophil serine proteases in the context of muscle regeneration with a special focus on muscle stem cell activation, and further validate them in appropriate cell and animal model systems.

PI_NAMEs: PISCONTI, ADDOLORATA  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acute;adult stem cell;Affect;Anatomy;Animal Model;Biochemical;Biological;Biological Assay;Biological Models;Biological Process;blood pressure control;Breathing;candidate validation;Cathepsin G;Cell Cycle;Cell model;cell type;Cells;congenic;Data;Data Set;Digestion;Disease;ECM receptor;Endocrine;Ensure;Environment;Enzyme-Linked Immunosorbent Assay;Enzymes;extracellular;Extracellular Matrix;Flow Cytometry;Food;Future;Genetic;Genetic Transcription;Goals;Growth Factor;Health;Hemostatic function;Histology;Homeostasis;Hour;Human;Human body;Image;Image Analysis;Immunohistochemistry;Impairment;In Vitro;in vitro Model;in vivo;injured;Injury;Investigation;Knock-out;Knockout Mice;Leukocyte Elastase;Life;Location;Locomotion;Macrophage;Maintenance;Mediating;Metabolism;Molecular;Mus;Muscle;muscle progenitor cell;muscle regeneration;Mutant Strains Mice;Myoblasts;Natural regeneration;neutrophil;Outcome;Pathway interactions;Peptide Hydrolases;pharmacologic;phenomics;Phenotype;phosphoproteomics;Physiological;Play;Population;premature;Process;Proteinase 3;Proteins;Proteomics;quantitative imaging;Reagent;recruit;regeneration potential;Regulation;response;response to injury;Role;self-renewal;Serine Protease;Services;Signal Pathway;Signal Transduction;Signaling Molecule;single nucleus RNA-sequencing;Skeletal Muscle;stem cell exhaustion;stem cell function;stem cell niche;stem cell population;stem cells;Stimulus;Stromal Cells;Structure;Testing;therapeutic target;three dimensional structure;Time;tissue regeneration;Tissues;tool;transcriptome sequencing;transcriptomics;tumor;Universities;Vision;Wild Type Mouse;Work

PROJECT_TITLE: Protease-mediated regulation of stem cell niche remodeling

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: NEW HAVEN

ORG_NAME: CORNOVUS PHARMACEUTICALS, INC.

PHR: Project Narrative Patients with ischemic stroke are in need of new medical therapy. Having identified a lead drug candidate with preclinical efficacy, the goal here is to develop this agent via IND-enabling process chemistry, GLP manufacturing of the compound and safety/toxicity studies. The proposed work would position us to complete IND-enabling studies in preparation for IND filing.

PI_NAMEs: LIANG, BRUCE  (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Acute;Adverse effects;Alteplase;analytical method;antagonist;Anti-Inflammatory Agents;Authorization documentation;Businesses;Canis familiaris;Cardiovascular system;Cells;Central Nervous System;Chemicals;Chemistry;Chronic;Clinical;clinical lot;Clinical Research;Collaborations;Connecticut;Cytochrome P450;Development;Diabetes Mellitus;Digestive System Disorders;Dose;drug administration duration;drug candidate;Drug Kinetics;endovascular thrombectomy;experimental study;Female;first-in-human;Formulation;functional improvement;Funding;genotoxicity;Goals;good laboratory practice;Good Manufacturing Process;Grant;Human;Immune;improved;in vivo;Infarction;Inflammation;Inflammatory;insight;intravenous administration;Investigation;Investigational Drugs;Investigational New Drug Application;Ion Channel;Ischemic Stroke;Kidney Diseases;Knowledge;Laboratories;Laboratory Research;Lead;Life Style;Macrophage;male;Mammals;manufacture;Measures;Mediating;Medical;medical schools;Methods;Micronucleus Tests;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Myelogenous;Myeloid Cells;National Heart, Lung, and Blood Institute;new chemical entity;No-Observed-Adverse-Effect Level;NOEL;novel strategies;novel therapeutics;old mice;Outcome;Patients;Pharmaceutical Preparations;Pharmacology;Pharmacology Study;Phase;Plasma;Population;Positioning Attribute;pre-Investigational New Drug meeting;preclinical efficacy;Preparation;Process;programs;Rattus;receptor;Recovery;Resolution;Resources;respiratory;Route;Safety;safety study;scale up;Science;screening;Small Business Technology Transfer Research;Stroke;stroke model;stroke patient;stroke therapy;success;Therapeutic;Toxic effect;translational study;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: A New Anti-inflammatory Therapy for Ischemic Stroke

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (10)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CLEMSON

ORG_DEPT: GENETICS

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE Work proposed here will combine genetically encoded biosensors in a multiplexed screening assay in live cells to identify small molecule probes capable of inhibiting glucose uptake and metabolism in kinetoplastid parasites in order to develop tools for exploring this important yet incompletely understood metabolic pathway. The proposed work is impactful, as it will pioneer a new self-validating screening methodology that will yield useful tools for understanding glucose metabolism at the cellular level in a group of important early-branching eukaryotes and could also be adopted for use in other organisms. Additionally, outcomes from the research have the potential to advance treatment of neglected tropical diseases that, in some cases, have currently inadequate therapies.

PI_NAMEs: CHRISTENSEN, KENNETH A;GOLDEN, JENNIFER E.;MORRIS, JAMES CULVIN (contact);WERBOVETZ, KARL A

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Address;Adopted;Antiparasitic Agents;Area;Biological Assay;Biology;Biosensor;carbohydrate metabolism;cell type;Cells;Cellular Assay;cellular targeting;chemical property;Chemicals;Chemistry;Collection;cytotoxicity;Development;Disease;Eukaryota;Evaluation;Flow Cytometry;Fluorescence Resonance Energy Transfer;Fructose;Future;genetic approach;Gluconeogenesis;Glucose;glucose metabolism;glucose uptake;Glycolysis;Glycosome;Goals;Health;high throughput screening;Human;improved;In Vitro;Individual;inhibitor;innovation;insight;Lead;Leishmania;Leishmania donovani;Libraries;Link;Maps;Measures;member;Metabolic;Metabolic Pathway;Metabolism;Methodology;Methods;Molecular Genetics;Monitor;multiplex assay;Nature;neglected tropical diseases;novel;novel strategies;Organism;Outcome;Outcomes Research;Parasites;Parasitic infection;pathogen;Pathway interactions;Permeability;Phenotype;Proteins;Proteomics;Pyruvate;Recombinants;Reporter;reverse genetics;Role;screening;sensor;Series;small molecule;Solubility;Stage Grouping;Time;tool;Trypanosoma brucei brucei;Validation;Visualization;Work;World Health Organization

PROJECT_TITLE: Development of a multiplexed assay in kinetoplastid parasites to identify probes for glycolysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(55)R]


ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: The epithelial-to-mesenchymal transition is a critical process in the dissemination of tumor cells from the primary tumor to distal organs. Tumor-initiating cells are formed in this transition, making possible the growth of new tumors at distal organs. Based on a novel mechanism by which the splicing of messenger RNA and the synthesis of new proteins encoded by that mRNA promotes this transition and tumor initiation, the proposed research will characterize new cellular mechanisms that may be targeted to suppress colorectal cancer.

PI_NAMEs: LEWIS, ROBERT E. (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Affect;Anchorage-Independent Growth;Automobile Driving;Behavior;behavior in vitro;Binding;Binding Sites;Cadherins;cancer cell;cell behavior;Cells;Characteristics;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Colorectal Cancer;colorectal cancer treatment;Computer Analysis;crosslink;Data;Distal;Drug resistance;epithelial to mesenchymal transition;Epithelium;Event;Exons;Gene Modified;Genes;Goals;Human;Hybrids;Immunoprecipitation;Impairment;improved;In Vitro;in vivo;inhibitor;innovation;Invaded;Knock-out;KRAS2 gene;KSR gene;Mediating;MEKs;Mesenchymal;Messenger RNA;Molecular;Motility;mouse model;mRNA Translation;Mutate;Mutation;N-Cadherin;Natural regeneration;Neoplasm Metastasis;neoplastic cell;new growth;novel;Organ;Organoids;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;polysome profiling;Population;prevent;Primary Neoplasm;Process;Proteins;Recurrence;Regulation;Research;Resistance;ribosome profiling;RNA Splicing;RNA, Messenger, Splicing;RNA-Binding Proteins;Role;scaffold;self renewing cell;self-renewal;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Testing;Therapeutic;therapy resistant;Translating;Translational Regulation;Translations;Treatment Failure;treatment response;tumor;tumor initiation

PROJECT_TITLE: Regulation of RBP Function during EMT

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


ORG_CITY: SEATTLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Intestinal helminth parasites that infect billions worldwide and cause significant morbidity are associated with a Type 2 inflammatory response. The factors that turn this response on and off, especially in affected tissues like the lung and intestine, are not completely understood, representing a major gap in our understanding. Studies in this application will explore how the lipid prostaglandin D2 and its receptor CRTH2 (chemoattractant receptor- homologous molecule expressed on Th2 cells) regulate innate immune and intestinal epithelial biology during Type 2 inflammation, informing efforts to target potent prostaglandin pathways to treat Type 2 inflammation- associated diseases including helminth infection and allergic disease.

PI_NAMEs: TAIT WOJNO, ELIA D (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Affect;Allergens;Allergic;Allergic Disease;Anti-Inflammatory Agents;Antiinflammatory Effect;Back;Biology;CD4 Positive T Lymphocytes;Cell Lineage;cell motility;Cell Physiology;cell type;Cells;cellular targeting;cytokine;Data;Disease;Dopamine D2 Receptor;Drug Modulation;Drug or chemical Tissue Distribution;Epithelial Cells;Epithelium;Equilibrium;Feedback;fMet-Leu-Phe receptor;Genes;Goblet Cells;helminth infection;Helminths;Hookworms;Human;Hyperplasia;Immune;Impairment;In Vitro;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Interleukin-13;Interleukin-4;Interleukins;intestinal epithelium;Intestines;Leukotrienes;lipid mediator;Lipids;Lung;Lymphoid Cell;Mediating;migration;Modeling;Morbidity - disease rate;mouse model;Mucins;Mus;Nematospiroides dubius;Nippostrongylus;novel;Parasites;Parasitic infection;Pathway interactions;Persons;Play;Positioning Attribute;Production;Prostaglandin D2;Prostaglandins;Pulmonary Inflammation;receptor;receptor expression;Reporter;Reporting;Research Design;Respiratory Disease;response;Role;Shapes;Signal Transduction;Small Intestines;Source;Testing;Th2 Cells;Tissues;Up-Regulation;Work

PROJECT_TITLE: Role of the prostaglandin D2 receptor CRTH2 in helminth-induced type 2 inflammation in the intestine

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Estrogen;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: A major challenge to patients with estrogen receptor (ER) positive breast cancer is the metastatic progression that significantly reduces their survival rate. This proposal aims to dissect the role and impact of androgen receptor (AR) on the metastatic progression of patients with gains of constitutively active ER mutations as a result of resistance to the aromatase inhibitor, a standard therapy that prevents the conversion of androgens to estrogens. The knowledge gained from this research will significantly advance our understanding of the critical signals and regulators that promote metastasis and facilitate the development of targeted therapies for ER mutant breast cancers.

PI_NAMEs: RICHER-MOUCHANTAT, JENNIFER ;YU, MIN  (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Adjuvant Therapy;Androgen Receptor;Androgens;antagonist;Aromatase Inhibitors;Automobile Driving;Binding;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;cancer subtypes;Cell Line;Cell Nucleus;Cell Proliferation;Cell Survival;Cells;Cellular Stress;Cleavage Under Targets and Release Using Nuclease;Data;defined contribution;deprivation;Development;Disease;enzalutamide;ERBB2 gene;ESR1 gene;Estrogen receptor positive;Estrogen Receptors;Estrogens;Feedback;Genes;Genetic;Goals;Hot Spot;Immunocompetent;immunodeficiency;In Vitro;in vivo;in vivo evaluation;inhibitor therapy;insight;intratumoral androgen;Invaded;knock-down;Knock-out;Knowledge;Laboratories;Malignant Breast Neoplasm;Mediating;Metastatic breast cancer;Modeling;mortality;Mus;mutant;Mutate;Mutation;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Nuclear;Outcome;Pathway interactions;patient derived xenograft model;Patients;Pattern;pharmacologic;Postmenopause;pressure;prevent;Production;Publishing;Reactive Oxygen Species;receptor binding;Receptor Cell;Receptor Inhibition;Receptor Signaling;Receptor Up-Regulation;receptor upregulation;Recurrence;refractory cancer;Relapse;Research;Resistance;Role;Signal Transduction;standard of care;Stress;Survival Rate;targeted treatment;Testing;TGFB1 gene;Therapeutic;therapy resistant;transcriptome sequencing;triple-negative invasive breast carcinoma;Tumor Cell Line;Up-Regulation;Woman

PROJECT_TITLE: The pro-metastatic role of androgen receptor in estrogen receptor mutated breast cancer


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Genetics;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Type 1 diabetes (T1D) is characterized by massive β-cell loss due to autoimmune destruction. The generation of pancreatic β cells derived from stem cells (SC-β-cell) holds great promise for cell replacement therapy for T1D patients, and may serve as a disease model to facilitate the discovery of new therapies. This research will improve SC-β-cells produced in the dish by correcting how these cells utilize glucose in their mitochondria, a key process mediating insulin secretion.

PI_NAMEs: ZHU, HAN  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Acceleration;autoimmune pathogenesis;Autoimmunity;Beta Cell;Biological Assay;Birth;Candidate Disease Gene;cell behavior;Cell Death;Cell Maturation;Cell model;Cell Physiology;cell replacement therapy;Cell Respiration;cell type;Cells;Chronic;Circadian Rhythms;computerized tools;coping;Cues;Development;Developmental Process;diabetes pathogenesis;Diagnosis;Disease;disease model;early childhood;Engineering;Engraftment;Environment;environmental change;environmental stressor;Epigenetic Process;epigenetic regulation;epigenome;Exhibits;experimental study;Exposure to;fetal;functional improvement;Gene Expression;Gene Expression Regulation;gene regulatory network;Generations;Genes;Genetic;Genetic Risk;Genetic Transcription;genome-wide;genomic data;genomic locus;Genomics;Glucose;Goals;histone acetyltransferase;histone methylation;histone modification;Human;human pluripotent stem cell;Immune;Immune system;improved;In Vitro;in vivo;Incidence;Individual;Inflammation;Inflammatory;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans;Link;Maps;Mediating;Metabolic;Metabolic Diseases;Methodology;Methods;Mitochondria;Modeling;Modification;Mus;Nature;NCOA1 gene;Neonatal;novel therapeutics;Nuclear Orphan Receptor;Nuclear Receptors;Nutrient;Nutrient availability;Oxidative Phosphorylation;Pathogenesis;Patients;Play;postnatal;Process;Production;programs;Regulator Genes;Repression;Research;Research Design;Resources;Respiration;Risk;risk variant;Role;screening;single cell genomics;stem cells;Stress;stressor;Structure of beta Cell of islet;Study models;Testing;theories;transcriptome;Transplantation;Work

PROJECT_TITLE: Gene regulatory programs drivingmetabolic maturation of human pluripotent stem cell derived β-cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-S (O2)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Estrogen;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative This proposal is relevant to public health because it seeks to understand how the X chromosome-encoded KDM5C protein regulates gene expression genome-wide in a sexually-dimorphic manner, including investigating how females with two X chromosomes and males with a single X chromosome equalize gene expression from the X chromosome, independently of gonadal hormones. The proposal is relevant to the part of the NIH mission that seeks to advance fundamental knowledge about the nature of living systems.

PI_NAMEs: KALANTRY, SUNDEEP  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Ablation;autosome;Cells;Chromatin;Chromatin Remodeling Factor;Data;demethylation;differential expression;Dissection;Dose;Embryo;embryo cell;Embryonic Development;embryonic stem cell;Enhancers;Epiblast;Epigenetic Process;Excision;experimental study;Female;Funding;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Goals;Gonadal Hormones;Histone H3;Histones;Hormones;innovation;Knowledge;Link;Lysine;male;Mammals;Mission;Modification;Mus;Nature;novel;Organism;Phenotype;prevent;Proteins;Public Health;Regulation;Repression;Research;Role;sex;Sex Bias;Sex Differences;sexual dimorphism;Source;sry Genes;stem cells;Technology;Testing;Tissue-Specific Gene Expression;Transcriptional Regulation;United States National Institutes of Health;Untranslated RNA;Work;X Chromosome;X Inactivation;Y Chromosome

PROJECT_TITLE: X-chromosome Inactivation Catalyzed by Genes that Escape X-inactivation

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Neurosciences;Sexually Transmitted Infections

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Herpes simplex virus infects >70% of the US population colonizing the nervous system for life. Episodic emergence of virus in response to stress can cause nervous tissue damage and is considered a risk factor for the onset of neurodegenerative disease. Knowledge gained in these studies will identify potential targets for new antiviral therapies.

PI_NAMEs: MOHR, IAN J;WILSON, ANGUS C (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Anti-viral Therapy;Behavior;biological adaptation to stress;Biology;Cells;Complex;Data;Disease;DNA biosynthesis;DNA-Directed DNA Polymerase;emerging virus;Ensure;Event;Exposure to;GADD45B;Gene Activation;Gene Expression;Genes;Genome;Goals;Health;Herpesviridae;Herpesvirus 1;Heterochromatin;Heterogeneity;Human;Immune response;Individual;Infection;Injury;Interruption;Knowledge;Learning;Life;Link;Mediating;Methodology;Minority;Modeling;Molecular;Nerve Tissue;Nervous System;Neurodegenerative Disorders;neuroinflammation;Neurologic;Neurons;Nuclear;Outcome;Parasites;Pathway interactions;Pattern;Physiological;Population;Process;Productivity;programs;promoter;protective factors;reactivation from latency;Recurrence;Regulation;Reproduction;resilience factor;response;Risk Factors;Role;Sensory;Shapes;Simplexvirus;single cell technology;single-cell RNA sequencing;Stimulus;Stress;stress resilience;Testing;Time;transcription factor;Viral;Viral Genes;Virus;Virus Latency;Virus Replication

PROJECT_TITLE: Interplay between nuclear stress responses and herpesvirus latency

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 VDT-Q (01)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autism;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: DAVIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE Although neurodevelopmental disorders are most commonly studied in childhood and adolescence, the trajectory of aging for the nearly 6 million adults in the United States currently living with autism spectrum disorder (ASD) remains largely unknown. With this study, we will evaluate age-related brain changes in socioemotional circuitry and begin to identify ASD phenotypes most vulnerable to pathological aging and windows of opportunity for intervention to promote healthy aging in this rapidly growing population.

PI_NAMEs: FOX, ANDREW S;MURRAY, KARL DANIEL;SCHUMANN, CYNTHIA  (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: abeta accumulation;Adolescence;Adult;adult with autism spectrum disorder;Affect;Age;age difference;age related;age related changes;Age-associated memory impairment;Aging;aging brain;Amyloid beta-Protein;Animal Model;Anterior;Anti-Inflammatory Agents;Array tomography;autism spectrum disorder;autistic children;Autopsy;Behavioral;Biological Assay;Brain;brain control;Brain Diseases;Brain region;brain tissue;brain volume;Cell Count;cell injury;Cell Nucleus;cell type;Cells;Childhood;Chronic;Clinical;Cognition;Collection;comparative;cytokine;Data;data reduction;Dementia;density;Development;differential expression;Disease;emerging adult;Emotional;emotional behavior;Fluorescent in Situ Hybridization;Functional disorder;Genes;genetic information;Genetic Transcription;Goals;Growth;healthy aging;Hippocampus;Human;IL18 gene;immune activation;Immunofluorescence Immunologic;Impaired cognition;Impairment;individuals with autism spectrum disorder;Inflammatory;Intervention;Knowledge;life span;Maps;Medial;Methods;Microglia;Molecular;Myelin;Nerve Degeneration;Neuroanatomy;Neurobiology;Neurodevelopmental Disorder;Neuroimmune;neuroinflammation;Neurons;neuropathology;Neuropil;neurotransmission;NF-kappa B;novel;Pathogenicity;Pathologic;pathological aging;Pathway interactions;Pattern;Phenotype;Population;precision medicine;preservation;Prevalence;Process;protein aggregation;Proteins;Proteomics;Publishing;receptor;Regulatory Pathway;Research;response;Risk;Sampling;sex;Signal Transduction;single molecule;single nucleus RNA-sequencing;Stains;Stress;Structure;Study models;Synapses;System;tau Proteins;Techniques;Thick;Transcript;transcriptomics;ultra high resolution;United States;Vertebral column;β-amyloid burden

PROJECT_TITLE: Brain Aging Across the Lifespan in Neurodevelopmental Disorders

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Discoveries from basic systems neuroscience demonstrate that external senses (such as vision) interact with the internally generated, cognitive representations that underlie thoughts, perceptions, experience, expectations, and so on. Cognitive disorganization and memory loss are devastating consequences of numerous forms of neurological and psychiatric disorders, including Alzheimer's Disease, stroke, and schizophrenia. These experiments will provide crucial information about the neural mechanisms that allow information from the external senses to interact adaptively with internally generated, cognitive representations, providing insight into how these processes are disrupted in neurological and psychiatric disease.

PI_NAMEs: COWAN, NOAH JOHN (contact);KNIERIM, JAMES J

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Alzheimer's Disease;Animals;Architecture;Autobiography;Behavior;Behavioral;Binding;Brain;Brain region;Calibration;Cells;Cognitive;cognitive function;cognitive process;Complex;Conflict (Psychology);Coupling;Cues;Dementia;Disease;Dorsal;Educational process of instructing;Engineering;Environment;expectation;experience;experimental study;Feedback;flexibility;Future;Hippocampal Formation;Hippocampus;Impaired cognition;insight;Location;Maps;Memory;Memory Loss;Mental disorders;Modeling;Motion;Movement;Nervous System;Nervous System Disorder;neural;neural network;Neural Network Simulation;Neurodegenerative Disorders;neuromechanism;Neurons;neurophysiology;Neurosciences;Nonlinear Dynamics;novel;optic flow;Organism;Output;Perception;Play;Positioning Attribute;Process;Rattus;Role;Schizophrenia;Sensory;sensory input;Series;Signal Transduction;Spatial Behavior;spatiotemporal;Stream;Stroke;Synapses;System;Techniques;Testing;Theta Rhythm;Thinking;Time;Travel;Update;virtual;virtual reality;virtual reality environment;virtual reality system;Vision;Visual;Weight;Work

PROJECT_TITLE: A Control Theoretic Approach to Addressing Hippocampal Function

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Brain Disorders;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: IRVINE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: We have sought the basis of spinocerebellar ataxia type 7 (SCA7) neurodegeneration by focusing on polyglutamine-expanded ataxin-7 transcription and epigenetic dysregulation, and after implicating DNA damage, metabolic dysregulation, mitochondrial abnormalities, and calcium dyshomeostasis in SCA7 disease pathogenesis, we are now performing single-cell transcriptome and epigenome analysis to define the cellular and molecular processes underlying both the cone-rod dystrophy retinal degeneration and cerebellar degeneration. Employing a novel Purkinje cell-enriched single nucleus (sn)RNA-seq method, we discovered altered synaptic organization and dramatic dysregulation of normal aldolase-C / zebrin-II expression patterning, and based upon analysis of related SCA polyQ disease model mice, altered cerebellar neurodevelopment is emerging as a shared disease feature across various polyQ cerebellar ataxias. We now wish to continue this line of investigation, and propose a series of experiments intended to identify DEGs and DARs from different cell types to reveal genes and regulatory elements that underlie the molecular pathology in SCA7 retinal degeneration and cerebellar degeneration, and then to determine the biological and physiological relevance of delineated transcription factor alterations and epigenetic dysregulation by modulating the expression and function of implicated factors in SCA7 knock-in model mice and by pursuing in vivo epigenetic rescue strategy involving use of Cre-inducible dCas9-p300 (or -KRAB) mice to determine if such interventions can ameliorate SCA7 retinal and cerebellar pathology, including disrupted zebrin-II patterning.

PI_NAMEs: LA SPADA, ALBERT R (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Aldolase C;Autopsy;Binding Sites;Bioinformatics;Biological;Calcium;cell type;Cells;Cerebellar Ataxia;Cerebellar degeneration;Cerebellar Diseases;Cerebellum;Chromatin;Classification;Compensation;Complex;cone-rod dystrophy;Data;defined contribution;Development;differential expression;Disease;disease model;DNA Damage;EP300 gene;Epigenetic Process;epigenome;Equilibrium;experimental study;Frequencies;Funding;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Grant;histone acetyltransferase;Histones;Human;in vivo;inducible Cre;Inherited;Inhibitory Synapse;Intervention;Investigation;knock-down;Knock-in;Knock-in Mouse;Link;Metabolic;Methods;Mitochondria;Molecular;molecular pathology;mouse model;multiple omics;Mus;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neurodevelopment;Neurons;novel;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern;pharmacologic;Physiological;polyglutamine;postsynaptic;preclinical trial;prevent;Process;Purkinje Cells;Regulatory Element;Resolution;Retina;Retinal Degeneration;Retinal Diseases;Sampling;SCA7 protein;Series;single nucleus RNA-sequencing;Synapses;synaptic function;System;Testing;Tissues;Transcription Alteration;Transcription Coactivator;transcription factor;transcriptome;Transgenic Mice;Type 7 Spinocerebellar Ataxia;ubiquitin isopeptidase;Validation;Work

PROJECT_TITLE: SCA7 neurodegeneration: Molecular epigenetic basis and therapy

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

PHR: NARRATIVE Memory loss is a devastating consequence of a number of neurological disorders, including Alzheimer's disease, stroke, and epilepsy. The hippocampus is a brain structure that is critical for the ability to form new memories and is highly susceptible to damage from these disorders, but the exact neural circuits and mechanisms underlying the role of the hippocampus in memory are not well understood. The results from this project will provide insight into how the normal brain encodes memories, which may provide powerful new clues to understand why deficits in memory arise from these neurological disorders and how these crippling deficits may be ameliorated.

PI_NAMEs: KNIERIM, JAMES J (contact)

PROJECT_TITLE: Multisite analysis of hippocampal neuronal ensembles


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Nuclear pore complex (NPC)-associated cofactors are shown to cooperate with the regulators of N6- adenosine methylation (m6A) to control the nuclear export of mRNAs, which is essential for normal functions of certain physiological processes. However, no studies have ever investigated the role of this cooperation in cancer. Our preliminary data demonstrated that the m6A methyltransferase METTL3 directly binds to a component of NPCs called NUP93 in cancer cells, which ensures the efficient export of m6A-containing mRNAs. Interestingly, a subgroup of the mRNA cargos of the METTL3-NUP93 complex in prostate cancer (PCa) cells are functionally enriched in biosynthesis of androgen, the ligand for the main driver of PCa progression — androgen receptor (AR). Thus, in this study we aim to (1). Elucidate how the METTL3-NUP93 complex selects the target mRNAs and facilitates their nuclear export; (2). Investigate how the m6A-METTL3- NUP93 axis increases the intratumoral androgen levels and stimulates AR activity; and (3). Evaluate the therapeutic potential of targeting the m6A-METTL3-NUP93 axis for the treatment of castration-resistant prostate cancer (CRPC), the most aggressive form of the disease. As such, our research will furnish novel insights into the functions of m6A and NPCs in PCa progression and offer promising anticancer drug targets.

PI_NAMEs: XU, KEXIN  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Acceleration;Adenosine;advanced prostate cancer;Affinity;Amino Acids;Anabolism;androgen biosynthesis;androgen independent prostate cancer;Androgen Receptor;Androgens;Animal Model;Antineoplastic Agents;Benign;Binding;Cancer Biology;cancer cell;Cancer cell line;cancer type;Castration;Cell Line;Cell model;Cell Nucleus;Cells;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Complex;Cytoplasm;Data;Development;Disease;DNA Sequence Alteration;Drug Targeting;Ensure;enzyme biosynthesis;Enzymes;Epithelial Cells;Event;Excision;experience;Fractionation;Functional disorder;Gene Expression Profile;Genes;Genetic;Genome;Gonadal Steroid Hormones;Growth;Hormones;Human;Immunohistochemistry;Individual;inhibitor;insight;Interruption;intratumoral androgen;Investigation;knock-down;Label;Ligands;Link;macromolecule;Malignant neoplasm of prostate;Malignant Neoplasms;malignant phenotype;Mediating;Messenger RNA;Metabolic;Methylation;Methyltransferase;Microscopy;migration;Modification;Molecular Mechanisms of Action;Movement;mutant;Mutate;Normal tissue morphology;novel;Nuclear;Nuclear Export;Nuclear Pore Complex;Nuclear Pore Complex Proteins;nucleocytoplasmic transport;Oncogenic;overexpression;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Phenotype;Physiological Processes;Play;Pre-Clinical Model;Primary Neoplasm;Proliferating;Prostate;prostate cancer cell;prostate cancer model;prostate cancer progression;Proteins;Proteomics;Receptor Signaling;recruit;Refractory;Reporting;Research;Resistance;Resolution;RNA;RNA methylation;RNA Recognition Motif;RNA Transport;Role;scaffold;Signal Transduction;Subgroup;Technology;Testing;Therapeutic;Tissues;tool;transcriptome;transcriptome sequencing;tumor progression;Tumor Promotion;Up-Regulation;Xenograft Model

PROJECT_TITLE: Function of the METTL3-NUP93 complex-mediated nuclear export of m6A-modified mRNAs in castration-resistant prostate cancer.

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Aberrant Protein Kinase A (PKA) signaling drives the growth and progression of a subset of lung, ovarian, liver, adrenal and gastrointestinal tumors. Pharmacologically targeting these aggressive cancers is challenging as directly inhibiting PKA has dire consequences such as heart failure, kidney dysfunction and diabetes. This multi- investigator project tests if PKAc-driven cancers can be treated by targeting its downstream effects on mRNA translation by inhibiting the helicase eIF4A rather than globally blocking the activity of the kinase.

PI_NAMEs: GORDAN, JOHN D (contact);SCOTT, JOHN D

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: A kinase anchoring protein;adenoma;Adrenal Gland Neoplasms;Apoptosis;Atrial myxoma with lentigines;BAG2 gene;Binding;Biogenesis;Biology;c-myc Genes;c-myc Proto-Oncogenes;Caring;Catalytic Domain;CCL4 gene;Cell Line;Cells;chaperonin;Chemicals;Clinical;Clinical Research;clinically relevant;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Dependence;derepression;Development;Diabetes Mellitus;Disease Progression;Drug Targeting;effective therapy;Elements;Endocrine Gland Neoplasms;Fibrolamellar Hepatocellular Carcinoma;forging;Foundations;Gastrointestinal Neoplasms;Gene Targeting;Generations;Genetic;Genetic Transcription;Growth;Heart failure;heat-shock proteins 40;Heat-Shock Proteins 70;helicase;Holoenzymes;in vivo;Incidence;Induction of Apoptosis;inhibitor;Island;kidney dysfunction;Lesion;Link;live cell imaging;Liver neoplasms;Lung;Lung Neoplasms;Malignant Neoplasms;Modeling;Molecular;mRNA Translation;mutant;Mutation;nano;nanoscale;novel;Oncogenic;Oncology;Outcome;Output;ovarian neoplasm;Pathway interactions;Patient Care;patient derived xenograft model;Patients;Peptide Initiation Factors;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;Physiological;Physiological Processes;Production;Proliferating;Property;Protein Inhibition;Protein Kinase;Protein-Serine-Threonine Kinases;Proteins;Proteomics;Radial;rare cancer;Rare Diseases;recruit;Regimen;Regulation;Research;Research Personnel;Resistance;response;Ribosomes;RNA Helicase;Role;Second Messenger Systems;Serine;Signal Transduction;Solid;Specificity;targeted treatment;Testing;Therapeutic;Therapeutic Index;therapeutic target;Tissue Sample;tool;Toxic effect;transcriptomic profiling;translational impact;Translational Repression;Translations;tumor;tumor growth;United States Food and Drug Administration;United States National Institutes of Health;Variant

PROJECT_TITLE: Targeting Oncogenic PKA signaling mechanisms

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome;Kidney Disease;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narratives: Congenital kidney diseases are the most common congenital disabilities, and Wilms tumor is the most common type of kidney tumor in children, accounting for nearly 90% of cases. This grant aims to elucidate the underlying causes of these diseases and address critical questions about how transcription factors interact with chromatin remodelers and cis-regulatory DNA elements to mediate the development of a small group of progenitor cells into large numbers of nephrons (blood-filtering units) in a mature kidney. Understanding how nephron progenitors are specified and maintained may eventually provide insights for preventing or treating these diseases.

PI_NAMEs: XU, PIN-XIAN  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Accounting;Address;ATP phosphohydrolase;Binding;Binding Sites;blood filter;Cell Cycle;cell fate specification;Cell Lineage;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;cofactor;Complex;Data;Dedications;Deposition;Development;disability;Disease;DNA;DNA Binding;DNA biosynthesis;DNA Repair;DNA Repair Gene;DNA-Binding Proteins;Elements;embryonic stem cell;Ensure;Environment;Epigenetic Process;Family;Family member;Follow-Up Studies;Functional disorder;Gene Activation;Gene Expression;gene repression;Gene Silencing;Genes;genetic corepressor;Genetic Transcription;Goals;Grant;helicase;homeodomain;human disease;insight;Kidney;Kidney Diseases;Kidney Neoplasms;loss of function;Mass Spectrum Analysis;Mediating;Mesenchyme;Mutation;Nephroblastoma;nephrogenesis;nephron progenitor;Nephrons;Nucleosomes;Pediatric Neoplasm;Phosphoric Monoester Hydrolases;Play;pluripotency;Predisposing Factor;prevent;progenitor;programs;protein expression;Proteins;RE1-silencing transcription factor;recruit;Regulation;Repression;Research;Rest;Role;self-renewal;single cell analysis;Site;Specific qualifier value;stem cell division;stem cell fate specification;stem cells;stemness;Transcription Coactivator;transcription factor;Transcription Repressor;Transcriptional Activation;transcriptome sequencing;Work;Zinc Fingers

PROJECT_TITLE: Transcription factors in kidney development

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: Public Health Narrative Many skin diseases such as inflammatory diseases are due to the dysregulated immune homeostasis in the skin. Understanding how the immune system in the skin is regulated is fundamental to understand the basis of immune homeostasis and inflammation in the skin, the largest barrier tissue of a body under frequent assaults of various environmental factors. Findings from our proposed study on regulation of skin-specific migration and localization of various innate-like T lymphocytes will aid our understanding of molecular mechanisms regulating the skin immune response and development of therapeutic targets in treatment of the skin inflammation diseases.

PI_NAMEs: XIONG, NA  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Address;Adult;Age;Applications Grants;assault;B-Lymphocytes;Birth;Cells;design;Development;Developmental Process;Disease;Environment;environmental agent;Environmental Risk Factor;Epithelium;Equilibrium;Exposure to;fetal;Fetal Liver;Generations;Goals;Health;Hematopoietic stem cells;Homeostasis;Homing;Immune;immune function;Immune response;Immune system;In Transferrin;Individual;Infant;Inflammation;Inflammatory;Iron;iron metabolism;Maintenance;migration;Molecular;Morphogenesis;Mucous Membrane;Nutrient;Play;postnatal;Property;Public Health;Publishing;Regulation;Role;Skin;skin disorder;Skin Tissue;Source;stem cells;T-Cell Development;T-Lymphocyte;Testing;Therapeutic;therapeutic development;therapeutic target;Thymus Gland;Time;Tissues;Transferrin;γδ T cells

PROJECT_TITLE: Development and function of skin-resident innate-like T cells at early postnatal stages

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: FORT COLLINS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Research suggests that synaptic activity and signaling can regulate social behavior that is essential to survive for many species. However, the links between synaptic regulation and social behavior are not completely understood. As δ-catenin is involved in the regulation of synaptic function and linked to autism, the proposed work will investigate the δ-catenin-mediated link of synaptic, cellular, and neural substrates to social behavior.

PI_NAMEs: KIM, SEONIL  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Acute;Address;Adult;Affect;AMPA Receptors;Amygdaloid structure;Animals;autism spectrum disorder;behavior test;Biological Assay;Cells;Data;delta-catenin;Disease;Ensure;Etiology;excitatory neuron;Excitatory Synapse;Family;Genes;Glutamates;Glycine;glycogen synthase kinase 3 beta;Glycogen Synthase Kinases;hippocampal pyramidal neuron;Hippocampus;Human;Impairment;Interneurons;knock-down;Knock-out;Knockout Mice;Link;Location;Medial;Mediating;Mental disorders;Missense Mutation;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;neural;Neurons;optogenetics;Parvalbumins;patch clamp;Pathway interactions;Patients;Pattern;Periodicity;Persons;postsynaptic;Prefrontal Cortex;Psyche structure;Reciprocal Social Interaction;Regulation;Research;Role;Serine;Signal Transduction;Slice;small hairpin RNA;social;Social Behavior;Social Change;Social Controls;social deficits;Social Interaction;Symptoms;Synapses;synaptic function;Testing;Thalamic structure;Viral;Wild Type Mouse;Work

PROJECT_TITLE: The roles of delta-catenin in social behavior

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Diabetes;Health Services;Patient Safety;Prevention

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative  We propose to develop rigorous and ﬂexible statistical tools for analyzing and decoding the rich glucose data from inpatient use of continuous glucose monitoring (CGM). The applications of the proposed statistical methods will generate useful insight for making evidence-based customized treatment decisions, leading to improved care for hospitalized patients with diabetes.

PI_NAMEs: PENG, LIMIN  (contact)

PROJECT_TERMS: Accounting;Address;Admission activity;Adopted;Adult;Area;Assessment tool;Blood capillaries;Body mass index;Caring;Cause of Death;Clinical;Continuous Glucose Monitor;cost;Data;Data Analyses;Detection;diabetes management;Diabetes Mellitus;disability;Evaluation;Event;evidence base;flexibility;Formulation;Future;Glucose;glucose monitor;glycemic control;Health Care Costs;Hospital complications;Hospital Mortality;Hospitalization;Hospitals;Hyperglycemia;Hypoglycemia;improved;Incidence;Individual;Individual Adjustment;individualized medicine;inpatient service;Inpatients;insight;interstitial;Intervention Studies;Joints;Length;Link;Methods;Modeling;Modernization;mortality;Multi-site clinical study;novel;Observational Study;Oral;Outcome;Patient Discharge;Patients;Pattern;Play;point of care;predictive tools;Procedures;Process;random forest;Recommendation;Recording of previous events;Recurrence;Reporting;Risk;Role;Safety;Scanning;semiparametric;Series;sound;Specific qualifier value;Statistical Data Interpretation;statistical learning;Statistical Methods;Stress;Techniques;Testing;Time;Time Factors;Time Study;tool;Translating;United States;user friendly software;wasting

PROJECT_TITLE: Developing statistical analysis and prediction tools for continuous glucose monitoring (CGM) use in hospitalized patients with diabetes

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Schizophrenia;Serious Mental Illness

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE Neurocognitive deficits represent a core component of several major neuropsychiatric disorders, most notably schizophrenia, affective disorders, autism spectrum disorders, and attention-deficit/hyperactivity disorder (ADHD). The proposed study is designed to exploit the Cognitive Genomics (COGENT) consortium dataset, in which we have performed large-scale genome-wide association studies of cognitive performance, as well as other publicly available genetic and neuroimaging datasets, to enhance our understanding of the causes of psychiatric illness and its treatment.

PI_NAMEs: LAM, MAX ;LENCZ, TODD  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Adult;Attention deficit hyperactivity disorder;autism spectrum disorder;Autopsy;Award;Biological;Biological Markers;Biology;Brain;Brain imaging;Brain region;Clinical;clinical application;clinical prognostic;clinically relevant;Cluster Analysis;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive performance;cognitive system;cognitive task;cohort;Complex;Data;Data Set;deprivation;design;Development;Diabetes Mellitus;Dissociation;Drug Targeting;endophenotype;ethnic diversity;exome;Family Study;Functional disorder;functional outcomes;Funding;General Population;Genetic;Genome;genome resource;genome wide association study;genome-wide;genomic data;genomic locus;Genomics;Impaired cognition;insight;Internet;Intervention;Investigation;large-scale imaging data;Longitudinal, observational study;Mediating;Mental disorders;Mental Health;Meta-Analysis;Modeling;Molecular;Mood Disorders;National Institute of Mental Health;Neurocognitive Deficit;neurodevelopment;neuroimaging;neuropsychiatric disorder;neuropsychiatry;Neurotransmitters;Nootropic Agents;novel;novel strategies;Outcome;Paper;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;pleiotropism;polygenic risk score;prenatal;Process;Prognosis;prognostic value;Progress Reports;prospective;Psychopathology;Publications;Publishing;rare variant;Reaction Time;Research Domain Criteria;Resolution;Risk;Sampling;Schizophrenia;Series;severe mental illness;Severities;side effect;skills;Symptoms;Synapses;Task Performances;Testing;trait;transcriptomics;Work

PROJECT_TITLE: Cognitive Genomics as a Window on Neurodevelopment and Psychopathology

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE One of the major challenges in vaccine development is access to adjuvants that promote long lived pathogen specific CD4+ and CD8+ T cell responses and provide protective cell mediated immunity. Our previous studies identified an adjuvant that induces protective long lived T cell populations in mice and primates but why this approach is so effective is unclear. Using next generation sequencing methods, we looked at what genes our vaccine-elicited cells were expressing. We found a unique gene expression program, guided by 2 factors that normally mediate opposing cellular functions to one another in a T cell responding to an infection. The overall goals of this project are to investigate what cellular function each factor is supporting, and how these normally competitive factors cooperate to keep the vaccine-elicited T cell alive and growing.

PI_NAMEs: KEDL, ROSS M (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Abbreviations;Adjuvant;ATAC-seq;Biology;Biomass;CD8-Positive T-Lymphocytes;Cell Physiology;cell type;Cells;Cellular biology;Cellular Immunity;ChIP-seq;Clinic;Clonal Expansion;Conscious;COVID-19 pandemic;cytokine;Data;Development;Disease;Epidemic;Epigenetic Process;Evaluation;fatty acid oxidation;FOXO1A gene;FRAP1 gene;Frequencies;Funding;Gene Expression;Genes;Genetic Transcription;Gluconeogenesis;Glycolysis;Goals;Immunity;Immunologics;Infection;Inflammation;insight;Interleukin-15;Investigation;Lipids;Listeria monocytogenes;Lymphocytic choriomeningitis virus;Mediating;Memory;Metabolic;Methods;Mitochondria;Modeling;Mus;Nature;next generation sequencing;nonhuman primate;novel;Oxidation-Reduction;Oxidative Phosphorylation;pathogen;Peroxisome Proliferator-Activated Receptors;Phenotype;Poliomyelitis;Population;Primates;Production;Productivity;programs;Proliferating;Publishing;Regulation;Research;response;RNA vaccine;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;SIRT1 gene;smallpox eradication;Subunit Vaccines;success;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;transcription factor;transcriptome sequencing;vaccine development;vaccine formulation;Vaccines;variants of concern;Yellow Fever

PROJECT_TITLE: Transcriptional and metabolic regulation of vaccine-elicited CD8+ T cell responses


ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE Electrical stimulation of the brain, including deep brain stimulation, effectively reduces seizures in patients with epilepsy, but rarely leads to complete freedom from seizures. Progress in improving this important therapy is being hampered by poor understanding of the mechanisms by which electrical stimulation reduces seizures. In this project we will elucidate mechanisms of DBS in epilepsy in an animal model and expect that a better knowledge of how neurons in specific networks are affected by electrical stimulation could lead to further improvement of this therapy with the goal of achieving seizure freedom in more, if not all patients.

PI_NAMEs: GROSS, ROBERT E;GUTEKUNST, CLAIRE-ANNE N (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Ablation;Address;Affect;Anatomy;Animal Model;Anterior;Anterior Nuclear Group;Area;Automobile Driving;Awareness;Axon;Behavior;brain abnormalities;Brain region;Cell Nucleus;Cells;Chronic;Clinical;clinical practice;Complex;Conscious;Deep Brain Stimulation;Devices;Disabling;Disease;Effectiveness;Electric Stimulation;Electrical Stimulation of the Brain;Electrodes;Electrophysiology (science);Epilepsy;Esthesia;Excision;experience;experimental study;Fiber;Freedom;Frequencies;Genetic;genetic approach;Glutamates;Goals;Guidelines;Hippocampus;improved;in vivo;Intractable Epilepsy;Kainic Acid;Knowledge;Lead;Lesion;Link;Location;medial temporal lobe;Mediating;Medical;Motor Cortex;mouse model;Nervous System Disorder;Neurons;neurotoxin receptor;novel therapeutics;Operative Surgical Procedures;Output;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Population;Resistance;Seizures;stem;Structure;System;Tegmentum Mesencephali;Temporal Lobe Epilepsy;Testing;Thalamic structure;Therapeutic Effect;Transgenes;Treatment Effectiveness;vector;Video Recording;Viral;Viral Vector;Virus;Work

PROJECT_TITLE: Deconstructing antiseizure mechanisms of anterior thalamic nucleus electrical stimulation

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: One in ten Americans are affected by chronic kidney disease (CKD). CKD is a gene environmental disease. Critical cell type(s) and pathway(s) responsible for disease development remains unknown limiting CKD understanding and new therapeutics development.

PI_NAMEs: SUSZTAK, KATALIN  (contact)

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Affect;American;Animal Model;Architecture;Atrophic;Basophils;CCL2 gene;Cell Communication;Cell Death;Cell secretion;cell type;Cells;chemokine;Chronic Kidney Failure;Collagen;Complement Factor B;Complex;Computer Analysis;CRISPR/Cas technology;CXCL1 gene;cytokine;Cytosol;Development;differential expression;Disease;disease model;Engineering;Epithelium;Etiology;Exhibits;experimental study;fatty acid oxidation;Fibroblasts;Fibrosis;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Grant;High-Throughput Nucleotide Sequencing;Histologic;Human;Hypoxia;Immune;Inflammatory;Informatics;injured;injury and repair;Injury to Kidney;Kidney;Kidney Diseases;kidney dysfunction;kidney fibrosis;Macrophage;Metabolic;Mitochondria;Mitochondrial DNA;mitochondrial metabolism;Mitochondrial RNA;Molecular;Mus;Mutation;Myofibroblast;Names;Natural regeneration;notch protein;novel;novel therapeutics;Nuclear;Nucleotides;Pathway interactions;Patients;PDGFB gene;Play;Process;programs;Rattus;Recording of previous events;Renal function;repaired;Resolution;response to injury;Role;Sampling;sensor;severe injury;Signal Transduction;single cell analysis;stem cells;Stimulator of Interferon Genes;Stromal Cells;TGFB2 gene;therapeutic development;TNF gene;tool;Toxin;transcription factor;Transforming Growth Factor Beta 2

PROJECT_TITLE: Adaptive and maladaptive repair after kidney injury

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Depression is a leading cause of disability, and for many individuals, existing antidepressants are slow to relieve symptoms or do not provide lasting benefits. This project will investigate the molecular and circuit-level mechanisms by which antidepressants act to reverse the effects of chronic stress on reward-seeking behavior, and how these effects are sustained over time. Our studies will advance our understanding of how the brain integrates information about rewards in our environment and the effort required to obtain them, and will potentially open new avenues for identifying novel treatment targets for anhedonia in depression.

PI_NAMEs: LEVITZ, JOSHUA ;LISTON, CONOR M (contact)

PROJECT_TERMS: Anhedonia;antagonist;anti-depressive agents;antidepressant effect;Automobile Driving;Autopsy;Behavior;Behavioral;Behavioral Paradigm;Brain;candidate identification;cell cortex;cell type;Cells;Chronic stress;cognitive function;Collaborations;Coupled;Cues;D Cells;Data;density;depressed patient;disability;Disinhibition;Electrophysiology (science);Elements;Environment;Event;Expenditure;Funding;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic;hippocampal pyramidal neuron;Image;Impairment;Individual;Interneurons;Ketamine;Learning;Mediating;Mental Depression;Modeling;Molecular;mood regulation;Moods;Motivation;mu opioid receptors;Neurons;neuroregulation;new therapeutic target;novel;Nucleus Accumbens;optogenetics;patch clamp;pharmacologic;Pharmacopoeias;photoactivation;Play;Prefrontal Cortex;receptor;reduce symptoms;restoration;reward anticipation;Rewards;Role;Signal Transduction;Somatostatin;spatiotemporal;Spinal Manipulation;Stress;Synapses;synaptogenesis;Testing;therapeutic target;Time;tool;transcriptome sequencing;treatment strategy;two-photon;Vertebral column;Visualization software;Work

PROJECT_TITLE: Neuromodulatory control of prefrontal circuit function and reward-seeking


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Harm Reduction for Substance Misuse;Mental Health;Mental Illness;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE Smokers with mental illness (MI) have dangerously high rates of smoking, low rates of quitting, and greater risk of tobacco-related disease and early death than any other group in the US, justifying creation of new harm reduction strategies for smokers who have been unable and/or are not ready to quit. After demonstrating in a randomized study that almost 19% of smokers with MI who received electronic cigarettes (e-cigs) for 8 weeks replaced their cigarettes with e-cigs and had significantly lower levels of cancer-causing chemicals, we developed “SWITCH IT,” a behavioral support and harm reduction approach designed to help smokers replace as many cigarettes as possible with e-cigs. The proposed study will randomly assign 250 smokers with MI to receive e-cigs for 8 weeks, with or without SWITCH IT, to examine specific ways SWITCH IT might help smokers reduce harm from smoking (such as by increasing confidence for using e-cigs instead of smoking to reduce stress) and further advance the science of tobacco harm reduction by exploring outcomes using different definitions of “switching” and harm reduction.

PI_NAMEs: PRATT, SARAH ILANA (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol;Abstinence;Adult;Affect;Behavior;behavior change;behavior measurement;Behavioral;Behavioral Mechanisms;Bipolar Disorder;cancer risk;Carcinogens;Cessation of life;Chemicals;Cigarette;cigarette smoke;cigarette smoking;Communities;Consumption;coping;craving;Cross-Sectional Studies;Dangerousness;design;Diagnosis;Disease;Education;Educational Curriculum;efficacy evaluation;efficacy testing;Electronic cigarette;electronic cigarette use;Exclusion;Expectancy;Exposure to;Feedback;General Population;Goals;Harm Reduction;Informal Social Control;learning strategy;Life Expectancy;Light;Lung;Maintenance;Malignant Neoplasms;Measures;Mental disorders;Mental Health Services;Morbidity - disease rate;mortality;negative affect;Outcome;Participant;Persons;Pilot Projects;Population;prolonged abstinence;prospective;Questionnaires;Randomized;Readiness;Reporting;Research;Risk;Role;satisfaction;Schizophrenia;Science;Self Efficacy;severe mental illness;Smoke;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;Stress;Stress and Coping;stress management;stress reduction;Testing;Time;Tobacco;Tobacco use;Toxicology;Training;Urine;US State;vaping;video chat

PROJECT_TITLE: Harm Reduction for Smokers with Mental Illness: RCT of E-cigarette Provision with or without Behavioral Support to Boost Switching

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]