NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Patients with Alzheimer's Disease have disturbances of circadian rhythms, the 24-hour cycles that control bodily processes such as sleep and hormone secretion. We will investigate how Alzheimer's Disease changes the circadian rhythms in different cell types in the brain. Conversely, we will determine how disruption of the circadian system in different cells of the brain causes inflammation and toxic protein accumulation in mouse models of Alzheimer's Disease.

PI_NAMEs: MUSIEK, ERIK STEVEN (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: abeta accumulation;Affinity;alpha synuclein;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;amyloid pathology;APP-PS1;ARNTL gene;Astrocytes;BAG3 gene;Behavior;Brain;brain cell;cell type;Cells;CHI3L1 gene;Chronic;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;circadian transcriptome;Clock protein;Confusion;Data;debilitating symptom;Deposition;Development;Disease Progression;Diurnal Rhythm;Environment;Functional disorder;Funding;Gene Expression;Genes;Genetic Transcription;Hormone secretion;Hour;Human;Impairment;in vivo;Inflammation;Inflammatory Response;insight;Mediating;Methods;Microglia;Modeling;Molecular Chaperones;mouse model;Mus;Neurobehavioral Manifestations;Neuroglia;neuroinflammation;Neurons;neuroprotection;new therapeutic target;novel;Pathogenesis;Pathology;Pathway interactions;Periodicity;Phagocytosis;Phase;Phenotype;Play;pre-clinical;prevent;Process;protein aggregation;protein degradation;Proteins;Regulation;response;Ribosomes;Role;Senile Plaques;Sleep;Sleep disturbances;suprachiasmatic nucleus;synergism;System;tau aggregation;tau Proteins;Therapeutic;Transcript;transcriptome sequencing;Translating;translatome

PROJECT_TITLE: ROLE OF GLIAL CIRCADIAN CLOCK DYSFUNCTION IN THE PATHOGENESIS OF ALZHEIMER'S DISEASE


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: BIRMINGHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative The University of Alabama at Birmingham Nathan Shock Center of Excellence in the Basic Biology of Aging will continue to provide state-of-the-art research services as well as diverse cells and animals for researchers investigating the links between energetics, health span and the aging as well as provide education and training in bioenergetics theory and analysis from the level of the organelle to the cell, tissue, organ, and organism.

PI_NAMEs: AUSTAD, STEVEN N. (contact);BUFORD, THOMAS W

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Adipose tissue;Affect;Aging;aging mechanism;aging process;Alabama;Ally;Animal Model;Animals;Autophagocytosis;Bioenergetics;Biology of Aging;Bivalvia;Body Composition;Body System;Brown Fat;Cell Aging;Cell Energetics;Cell Nucleus;Cell Physiology;Cells;Chronic Disease;Collaborations;Communication;Communities;comparative;Comparative Biology;Complex;Country;Cytoplasm;Data Analytics;Data Set;detection of nutrient;Discipline;Disease;Dissection;DNA Repair;Education;Elephants;energy balance;Environment;Expenditure;Experimental Designs;experimental study;Fishes;fly;Fostering;FRAP1 gene;gene network;Geroscience;Glycolysis;Goals;Health;health assessment;healthspan;Infrastructure;innovation;Instruction;instrumentation;Insulin;Intake;interest;International;Laboratories;late life;Life;Link;Longevity;Malignant Neoplasms;Mammals;Measurable;Metabolic;metabolic abnormality assessment;Metabolic Pathway;metabolic rate;Metabolism;metabolomics;Methodology;Mitochondria;Mitochondrial DNA;Modeling;Modernization;Mole Rats;Morphology;Mus;novel;Nuclear;Nutrient;Organ;Organelles;Organism;outreach;Oxidative Phosphorylation;Oxidative Stress;Oxygen;Pattern;Physical activity;Population;Process;Production;Productivity;programs;proteostasis;Rattus;reduced food intake;Regulation;repaired;Research;research and development;Research Infrastructure;Research Personnel;Resources;response;Services;Shock;Signal Transduction;symposium;Techniques;Technology;Temperature;theories;tissue regeneration;Tissues;Training;Training and Education;Training Support;Twin Multiple Birth;Universities;Update;Variant;virtual;Whole Organism

PROJECT_TITLE: Comparative Bioenergetics of Aging


NIH_SPENDING_CATS: Aging

PI_NAMEs: HARTMAN, JOHN L (contact)

PROJECT_TERMS: Address;Aging;aging related;Alabama;Area;Automobile Driving;Award;Basic Science;Bioenergetics;Biological;Biology;Biology of Aging;Biomedical Research;Budgets;career development;Collaborations;comparative;Comparative Biology;Consultations;Core Facility;Development;Education;Educational Materials;experience;Experimental Designs;Faculty;Feedback;Fostering;Funding;Funding Mechanisms;Goals;Grant;Institution;Journals;Leadership;meetings;member;Mentors;Monitor;next generation;Outcome;Phase;Pilot Projects;Positioning Attribute;Procedures;Process;Production;Program Development;programs;Publications;Research;research and development;Research Personnel;Research Project Summaries;Research Training;Resources;Role;Science;Scientist;Series;Services;Shock;Sister;Study Section;success;symposium;synergism;training opportunity;Universities

PROJECT_TITLE: Core B - Research Development Core


ADMINISTERING_IC: DK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: NARRATIVE Adipocytes are central regulators of metabolic function and dysfunction. We have recently identified several subpopulations of human white adipocytes using single nucleus RNA-seq, although we still know little about how they develop, what their functions are, and where they reside in the fat pad. The studies in this proposal will address these issues using state-of-the-art multi-omic technologies, and will allow us to model specific subpopulations in vitro, enabling further downstream studies. Finally, we will build and populate a Human Adipose Tissue Knowledge Portal to disseminate our findings and those of other groups to the community at large.

PI_NAMEs: ASHENBERG, ORR ;BURTT, NOEL P;CLAUSSNITZER, MELINA C;FLANNICK, JASON ;ROSEN, EVAN D (contact);TSAI, LINUS TZU-YEN

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Abdomen;Address;Adipocytes;adipokines;Adipose tissue;Affect;ATAC-seq;Automobile Driving;Binding;Biology;Blood Vessels;Bone Marrow;Catalogs;Categories;Cell Nucleus;Cell Ontogeny;Cell Physiology;cell type;Cells;Chromatin;Communities;Complex;CRISPR-mediated transcriptional activation;Data;Data Analyses;Data Set;Databases;Development;Disease;Exhibits;Fatty acid glycerol esters;Functional disorder;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;genome-wide;Grant;Health;Heterogeneity;Histologic;Homeostasis;Human;human disease;Hyperlipidemia;Image;Immune;In Vitro;Individual;intercellular communication;Kidney;Knowledge;Knowledge Portal;lipidomics;Lymphedema;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;metabolomics;Modality;Modeling;multiple omics;Mus;Nerve;Nodal;Nomenclature;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;Obesity;outreach;Participant;Pathway interactions;Phase;Phenotype;Physiological;Physiology;polygenic risk score;Population;Predictive Factor;Predisposing Factor;Prevalence;programs;Proteomics;Protocols documentation;Resources;screening;Signaling Molecule;single nucleus RNA-sequencing;spatial relationship;Standardization;subcutaneous;System;Techniques;Technology;Testing;trait;transcription factor;transcriptome sequencing;Untranslated RNA;Variant;Visceral;Waist-Hip Ratio;web based interface;web portal;Work

PROJECT_TITLE: Investigating Human Adipocyte Heterogeneity


PI_NAMEs: AUSTAD, STEVEN N. (contact)

PROJECT_TERMS: Advisory Committees;Aging;aging process;Ally;arm;Bioenergetics;Biological;Biology of Aging;Capsicum;career;Cells;Chronic Disease;Collaborations;Communication;Communities;comparative;Consultations;Data Analytics;Discipline;Education and Outreach;Energy Intake;Evaluation;experience;Fostering;Geroscience;Goals;Health;health assessment;Human Resources;Institution;Journals;late life;Leadership;Maintenance;meetings;Mitochondria;Modeling;Molecular;National Institute on Aging;Occupational activity of managing finances;Organelles;Organization administrative structures;outreach;outreach services;Performance;Persons;Privatization;Process;programs;prospective;Reporting;Research;research and development;Research Personnel;Resources;Shock;skills;symposium;synergism;Tissues;Training and Education;Update;virtual;Whole Organism

PROJECT_TITLE: Core A - Administrative Program Enrichment Core


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Natural Products;Neurosciences;Nutrition;Pediatric;Prevention

ORG_CITY: CHAMPAIGN

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative The proposed research is relevant to human health because it will provide novel data supporting evidence-based recommendations to improve dietary practices for optimal cognitive function and achievement in childhood. Establishing the evidence base for nutrients that may have neurocognitive implications is particularly important given that the majority of children in the United States perpetually consume diets that fail to achieve their recommended servings of vegetables. Therefore, by furthering our understanding of nutrition for children’s cognitive function, the proposed research is relevant to the NIH mission to improve the health of the nation.

PI_NAMEs: KHAN, NAIMAN  (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: 10 year old;Academic achievement;Achievement;Antioxidants;Attention;Brain;Carotenoids;Central Nervous System;Child;Child Nutrition;Childhood;Cognition;Cognitive;cognitive benefits;cognitive control;cognitive development;cognitive function;Collaborations;Consumption;Control Groups;Darkness;Data;Data Set;density;design;Diet;Dietary Carotenoid;dietary guidelines;Dietary Practices;Double-Blind Method;double-blind placebo controlled trial;EP300 gene;Event;evidence base;evidence based guidelines;executive function;Exhibits;Eye;Food;Health;Health Promotion;Hippocampus;Human;improved;indexing;information processing;innovation;insight;Intake;Intervention;Isomerism;Knowledge;Laboratories;Learning;learning ability;life span;Link;Lutein;macula;Measures;Mediating;Membrane;Memory;Mission;neural;Neurocognitive;novel;Nutrient;nutrition;Nutritional;nutritional approach;Optics;Outcome;Parents;Pattern;Performance;Pigments;Placebo Control;placebo group;Plants;Policy Maker;Positioning Attribute;preadolescence;primary outcome;processing speed;Publishing;Randomized;Reaction Time;Recommendation;reconstruction;Recording of previous events;relational memory;Research;Resource Allocation;Retina;Role;Schools;secondary outcome;Shapes;success;Supplementation;Surrogate Markers;Task Performances;teacher;Testing;Time;Tissues;United States;United States National Institutes of Health;Vegetables;Vocation;Waiting Lists;Work;zeaxanthin

PROJECT_TITLE: Enhancing Children's Cognitive Function and Achievement through Carotenoid Consumption

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


PI_NAMEs: SMITH, DANIEL L (contact)

PROJECT_TERMS: Aging;aging related;Animal Model;animal model selection;Area;Behavior;behavioral outcome;Biochemical;Bioenergetics;Biological Aging;Biology of Aging;Body Composition;Caenorhabditis elegans;Communities;comparative;Daphnia;Development;Drosophila genus;Dual-Energy X-Ray Absorptiometry;Eating;energy balance;Energy Metabolism;Equipment;functional outcomes;Genetic;healthspan;Human Resources;improved;Institution;instrumentation;Intervention;life span;Magnetic Resonance;Measures;Methodology;microCT;Mission;model organism;Modeling;National Institute on Aging;novel;Nutritional;Organism;Procedures;Research;Research Personnel;Resources;Rodent;Services;Shock;Training and Education;Zebrafish

PROJECT_TITLE: Core C - Comparative Organismal Energetics Core


PI_NAMEs: ZHANG, JIANHUA  (contact)

PROJECT_TERMS: Adipose tissue;age related;age related changes;age-related disease;Aging;aging mechanism;aging process;Bioenergetics;Biology;Cells;Cellular Structures;Chronic Disease;Communities;comparative;Complex;Consultations;Data;Data Analyses;Development;Disease;DNA Sequence;Education;Educational workshop;Ensure;Experimental Designs;Failure;follow-up;Freezing;Funding;Genetic;Genetic Complementation Test;Gerontology;Grant;Haplotypes;Health;health assessment;healthspan;healthy aging;Immune response;indexing;Inflammatory;Innate Immune Response;interest;Islets of Langerhans;Kidney;Lead;Link;Longevity;Maintenance;Mass Spectrum Analysis;Measurement;Measures;member;Metabolic;Metabolic stress;Metabolism;metabolomics;Methodology;Methods;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Molecular;Mus;novel;novel strategies;Nuclear;Organism;Oxidation-Reduction;Oxidative Stress;oxidized lipid;Pattern;Permeability;Plasma;Process;programs;Proteins;Protocols documentation;Publishing;Quality Control;Recurrence;Research;Research Personnel;Resistance;response;Role;Sampling;Scientist;Serum;Services;Shock;Signal Transduction;spheroids;Sulfhydryl Compounds;Surveys;Techniques;Technology;Testing;Tissue Sample;Tissues;tool;Training and Education;virtual;Work;Zebrafish

PROJECT_TITLE: Core D - Comparative Mitochondrial Health Assessment Core


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE  The Midwest Consortium for Hazardous Waste Worker Training facilitates adult-based, action-oriented, results-centered worker and community training with the goal that participants will better recognize and avoid or control risks of occupational and environmental exposure to hazardous materials and waste in nine states: Illinois, Indiana, Kentucky, Michigan, Minnesota, North Dakota, Ohio, Tennessee, and Wisconsin. While all activities are performed under a cooperative agreement with the National Institute of Environmental Health Sciences, the training also leverages the resources of U.S. government agencies including the Environmental Protection Agency, Occupational Safety and Health Administration, Department of Homeland Security, National Institute for Occupational Safety and Health, Agency for Toxic Substances and Disease Registry, Department of Transportation, and Chemical Safety and Hazard Investigation Board. Midwest Consortium training centers include labor-affiliated programs, three major universities, two community colleges, an historically black university, an affiliate of a national youth training organization, a tribal nation, and several other community-based organizations, all of which form partnerships locally and regionally to build capacity among trainees to recognize and react to hazardous substances in their workplaces and communities.

PI_NAMEs: RAYNOR, PETER C. (contact)

PROGRAM_OFFICER_NAME: PERSAUD, ERIC

PROJECT_TERMS: Address;Adult;Catalogs;chemical safety;Chemicals;Client;Communication;Communities;community center;community college;community organizations;Community Workers;Country;Creativeness;curriculum development;Data;Data Reporting;data to knowledge;Databases;Dedications;disease registry;Educational Curriculum;Emergency response;Environment;Environmental and Occupational Exposure;Environmental Exposure;Environmental Health;Equipment;ethnic diversity;Evaluation;experience;Exposure to;Faith;Foundations;Funding;Goals;Government Agencies;hazard;Hazard Controls;Hazardous Substances;Hazardous Waste;Hazardous Waste Operations and Emergency Response;Hazardous Waste Sites;Health;Healthcare Systems;Historically Black Colleges and Universities;Hour;Human Resources;Illinois;improved;Indiana;Industrialization;innovation;instructor;Investigation;Journals;Kentucky;Knowledge;Learning;Limited English Proficiency;literacy;meetings;Michigan;Midwestern United States;Minnesota;Modeling;Motivation;National Institute for Occupational Safety and Health;National Institute of Environmental Health Sciences;neighborhood association;Nonprofit Organizations;North Dakota;novel;Occupational Health;occupational health/safety;Occupations;Ohio;Opioid;Output;Participant;Poison;Prevention;Procedures;Production;Program Evaluation;programs;Public Health;Publications;racial diversity;Reaction;Reporting;Research;resilience;Resources;Risk;Role;Safety;Security;Services;Site;skills;Strategic Planning;Superfund;symposium;Tennessee;Time;Toxics Release Inventory;Training;Training Programs;Translations;Transportation;tribal Nation;tribal organization;U-Series Cooperative Agreements;Underserved Population;United States Environmental Protection Agency;United States Occupational Safety and Health Administration;Universities;Update;Wisconsin;Work;Workplace;Youth


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE No effective treatment exists for Angelman syndrome, a neurodevelopmental disorder caused by maternal allele deletions of the UBE3A gene. However, activation of the epigenetically-silenced paternal UBE3A allele in neurons offers an attractive therapeutic target. We have discovered a small molecule that can be administered peripherally to unsilence the dormant paternal UBE3A allele throughout the brain, and we propose to advance this small molecule towards a potentially transformative treatment for Angelman syndrome.

PI_NAMEs: AUBE, JEFFREY ;PHILPOT, BENJAMIN D (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Alleles;analog;Anatomy;Angelman Syndrome;Antisense Oligonucleotides;autism spectrum disorder;Behavioral;Biodistribution;Biological Availability;Biology;Biotinylation;blood-brain barrier penetration;Brain;CDK2 gene;Cells;Chemistry;Clinic;Clinical;Clinical Trials;comorbidity;Data;Development;Dose;effective therapy;Electrophysiology (science);enantiomer;Epigenetic Process;experimental study;Failure;Future;Human;improved;Individual;inhibitor;insight;Intrathecal Injections;lead candidate;Life;mouse model;Mus;Mutation;Neurodevelopmental Disorder;Neurons;novel;patient population;Peripheral;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacology;Phenotype;Physiological;postnatal;Property;protein expression;Proteins;Regimen;Research;safety study;screening;small molecule;small molecule therapeutics;Source;stem cells;Structure-Activity Relationship;Surveys;Testing;Therapeutic;therapeutic target;Topoisomerase;Topoisomerase Inhibitors;Topotecan;Toxic effect;Transcript;UBE3A gene;ubiquitin-protein ligase;Untranslated RNA;Work

PROJECT_TITLE: Small Molecule Therapeutic Discovery for Angelman Syndrome

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


NIH_SPENDING_CATS: Aging;Bioengineering;Networking and Information Technology R&D (NITRD)

PI_NAMEs: ALLISON, DAVID B (contact)

PROJECT_TERMS: Academy;Address;Aging;Agreement;Anatomy;Basic Science;Bioenergetics;Biological Sciences;Biology;Biology of Aging;Body Composition;Clinic;Collaborations;Communities;comparative;Comparative Biology;Comparative Study;Competence;Computational Science;computer science;Computers;Data;Data Analytics;Dependence;design;Development;Discipline;Engineering;Event;experience;Face;Frequencies;Genomics;Hand;Health;health science research;higher level mathematics;Investigation;Investments;Leadership;Learning;Left;life span;longitudinal analysis;Longitudinal Studies;mathematical sciences;Mathematics;Measurement;Medicine;Methods;model organism;Modeling;National Research Council;Organism;Outcome;Phylogenetic Analysis;Procedures;Publications;Recording of previous events;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Residual state;Respondent;Sampling;Science;Scientist;Statistical Data Interpretation;Statistical Methods;Statistical Models;statistics;Structure;success;Surveys;Time;Training;United States National Institutes of Health;Work

PROJECT_TITLE: Core E - Comparative Data Analytics Core


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Scientists have been pinpointing tens of thousands of positions in the human genome which may influence disease. In order to apply this knowledge to improve treatment options and preventative medicine, however, we need to have a better understanding of how these regions function and where in the body they are active. This project is a predictive modeling component of the IGVF Consortium, which aims to systematically study the functional impact of genetic variants and their influence on human diseases and traits by developing and applying cutting-edge computational and statistical methods to predict the functional impacts of disease-associated genetic variants.

PI_NAMEs: GARBER, MANUEL ;LIN, XIHONG ;WENG, ZHIPING  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;advanced analytics;Algorithms;analytical method;Base Pairing;biobank;Biological Assay;candidate identification;Catalogs;catalyst;causal variant;cell growth;cell type;Cells;Chromatin;Classification;cloud based;Cloud Computing;Collaborations;Collection;Communities;Computer Models;Computing Methodologies;Data;Data Analyses;Data Commons;Data Set;Databases;design;Disease;Elements;Environment;feature selection;Gene Expression;Genes;genetic variant;genome sequencing;genome wide association study;genomic variation;Genomics;Human;human disease;Human Genome;Immune;improved;innovation;Joints;Knowledge;Learning;Link;machine learning method;machine learning model;Maps;Mediating;member;Mental disorders;Metabolic;Methods;Modeling;Molecular Conformation;molecular phenotype;multi-ethnic;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;novel;Nuclear Structure;Phenotype;Physiological;Population;Population Heterogeneity;Positioning Attribute;predictive modeling;Preventive Medicine;programs;rare variant;Records;Regulatory Element;Research Personnel;Resolution;response;RNA;Role;Science;Scientist;Source;statistical learning;Statistical Methods;Stimulus;Targeted Research;Testing;Tissues;tool;trait;Trans-Omics for Precision Medicine;transcriptome;Untranslated RNA;Variant;variant of interest;Veterans;Visualization software;web portal;whole genome;Work

PROJECT_TITLE: Predictive Modeling of the Functional and Phenotypic Impacts of Genetic Variants


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Microvascular dysfunction is a central pathogenic feature of chronic kidney disease, but routine assessment of renal microcirculation is difficult without a kidney biopsy. Whether non-invasive measurement of microvascular abnormalities can identify persons at risk for future loss of kidney function is unknown. The objectives of this proposal are to 1) understand how microvascular measurements are related to kidney histology, 2) investigate clinical determinants of microvascular dysfunction in kidney disease patients, 3) determine whether microvascular dysfunction is associated with kidney disease progression over time and 4) evaluate whether non-invasive microvascular measurements can determine renal function reserve.

PI_NAMEs: MALHOTRA, RAKESH  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acute;Affect;Albuminuria;Assessment tool;Basement membrane;Blood capillaries;Blood Vessels;boys;California;Cardiovascular Diseases;career;Cessation of life;Chronic Kidney Failure;cigarette smoking;Clinical;clinical predictors;clinical risk;Clinical Trials;Data;density;design;Diabetes Mellitus;Dietary Proteins;disease prognosis;Disease Progression;Doctor of Philosophy;Educational workshop;End stage renal failure;Enrollment;experience;follow-up;Future;Gender;Glomerular Filtration Rate;glomerulosclerosis;Glucose;Health;hemodynamics;Hemorrhage;high risk;Histology;Histopathology;human old age (65+);Hyperemia;Hypertension;improved;Individual;insight;Intervention Studies;Kidney;kidney biopsy;Kidney Diseases;Laser-Doppler Flowmetry;Lasers;Lead;Learning;male;Measurement;Measures;Mentors;Mentorship;Methods;Microcirculation;Microscopic Angioscopy;Microvascular Dysfunction;minimally invasive;Monitor;multidisciplinary;Nephrectomy;non-invasive monitor;novel;Operative Surgical Procedures;Oral;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathologist;patient oriented research;Patients;Peripheral;Persons;Pharmaceutical Preparations;Phase;Physiological;Play;Population;Populations at Risk;Prognosis;programs;Proteins;rate of change;recruit;Renal Carcinoma;Renal function;Research;Research Personnel;response;Risk;Risk Factors;Role;Scientist;skills;Skin;Statistical Methods;Stimulus;Structure of glomerular mesangium;Techniques;Technology Assessment;Time;Tissues;Titrations;Training;Translations;treatment response;Universities;Urologist;vascular abnormality

PROJECT_TITLE: Non Invasive Assessment of Microcirculation Function and Kidney Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Health Services;Mental Health;Mental Illness;Physical Rehabilitation;Psychosis;Rehabilitation;Serious Mental Illness;Social Determinants of Health

PHR: PROJECT NARRATIVE  This pilot project will demonstrate the feasibility, acceptability, fidelity, and preliminary indicators of effectiveness of a positive, recovery-focused model of post-acute community-based rehabilitation for people living with psychosis in resource-limited settings, laying the groundwork for further effectiveness and scale-up research. The adaptation of the community-based rehabilitation model for this population will be grounded in the perspectives of people with lived experience along with their caregivers, community leaders, and other key stakeholders. This work will provide a critical advance toward establishing the evidence base for community- based treatment models for community-dwelling people with psychosis to enhance rehabilitation, functioning, quality of life, and recovery.

PI_NAMEs: KULISEWA, KAZIONE ;PENCE, BRIAN W (contact)

PROGRAM_OFFICER_NAME: CUBILLOS, LEONARDO

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Admission activity;Ambulatory Care;Caregivers;Caring;Chronic;Collaborations;Communities;community based care;community based treatment;community-level factor;Conflict (Psychology);Country;disability;Disabled Persons;Effectiveness;emerging adult;empowerment;Enrollment;evidence base;Family;family burden;Family member;Goals;Home;Human Resources;improved;improved outcome;Individual;Inpatients;Interview;Lived experience;low and middle-income countries;Malawi;Manuals;Medical;medical specialties;medication compliance;Medication Management;member;Mental Health;Mental Health Services;Modeling;Morbidity - disease rate;mortality;Nurses;Outpatients;Patient-Focused Outcomes;Patients;person centered;Persons;Pilot Projects;pilot test;pilot trial;Policies;Population;Positioning Attribute;Process;Productivity;programs;Psychiatric Hospitals;Psychiatric therapeutic procedure;Psychoses;Psychotic Disorders;Public Sector;Quality of life;Randomized;Randomized, Controlled Trials;Recovery;reduce symptoms;Rehabilitation therapy;Relapse;relapse prevention;Religion;Research;Resource-limited setting;Risk Factors;Role;scale up;Services;Severities;social inclusion;social stigma;South Africa;Symptoms;Time;treatment as usual;Work

PROJECT_TITLE: Enhancing post-acute mental health outcomes for patients with psychosis in Malawi  through nurse-delivered community-based rehabilitation: The ENHANCE Pilot Trial


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The UCSF Chemistry and Chemical Biology (CCB) Program trains bright, creative and diverse scientists to apply innovative chemical approaches in the responsible pursuit of the most important biomedical problems. Graduates are prepared to become the next generation of influential leaders in academics, industry and beyond.

PI_NAMEs: GESTWICKI, JASON E (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Research Training in Chemistry and Chemical Biology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: The goal of this proposal is to characterize mechanisms by which methamphetamine (meth) increases uninfected and HIV infected CD14+CD16+ monocyte transmigration across the BBB to CXCL12, increasing perivascular and parenchymal macrophage accumulation in the CNS of PWH with meth use disorder. There is increased prevalence of HIV associated neurocognitive disorders or impairment (HAND, HIV-NCI) in people with HIV (PWH) greatly impacting their quality of life. A significant number of people with meth use disorder are PWH, with increased neurocognitive impairments reported in active meth using PWH. The mechanisms by which meth use disorder increases HIV-NCI in PWH on antiretroviral therapy are not completely characterized, impeding the development of interventional strategies to reduce/ eliminate HIV-NCI.in this population. The role of CXCR7 and/or CXCR4 in these meth mediated effects is the focus of this proposal. We hypothesize that CXCR7 and/or CXCR4 contribute to meth mediated increases in CXCL12 induced uninfected and HIV infected CD14+CD16+ monocyte transmigration,Thus, CXCR7 may be a therapeutic target for HIV-NCI treatment in PWH with meth use disorder. We will use our in vitro human BBB model to characterize the role of CXCR7 and/or CXCR4 in meth mediated effects on transmigration and on cells of the BBB. We will determine effects of meth on CXCR7 and/or CXCR4 expression, and on CXCL12 induced signaling, adhesion, and chemotaxis in uninfected/HIV infected CD14+CD16+ monocytes. The in vivo effects of meth on monocyte influx into the infected CNS will be examined in CNS tissue sections from meth treated SIV infected macaques by immunohistochemical analyses of BBB expression of CXCL12, and perivascular and parenchymal accumulation of CXCR7 and/or CXCR4 expressing monocytes/macrophages.

PI_NAMEs: BERMAN, JOAN WEINBERGER (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Adhesions;antiretroviral therapy;Astrocytes;B-Lymphocytes;Behavior Disorders;beta-arrestin;Biological Process;Blood - brain barrier anatomy;Blood Cells;Blood Vessels;Brain;brain cell;CCL2 gene;CD14 gene;cell motility;Cells;chemokine;chemokine receptor;Chemotaxis;Chemotaxis Induction;Chronic;Circulation;Cognition Disorders;comorbidity;CXCR;CXCR4 gene;cytokine;Data;Defect;Development;Embryo;Endothelial Cells;Environment;Exposure to;extracellular;FCGR3B gene;Goals;Hand;Heart;Heterodimerization;HIV;HIV Infections;HIV-associated neurocognitive disorder;Human;Impaired cognition;In Vitro;in vivo;Infection;Inflammatory;Intervention;Invaded;Laboratories;Macaca;Macrophage;Mediating;Methamphetamine;methamphetamine effect;methamphetamine use;Methamphetamine use disorder;migration;Modeling;monocyte;motor disorder;Mus;Neurocognitive Deficit;neuroinflammation;Neurons;Neuropathogenesis;neurotoxic;novel;Peripheral;Persons;Population;Prevalence;Process;Production;Public Health;Quality of life;receptor;Reporting;response;Role;Signal Induction;Signal Pathway;SIV;Stromal Cell-Derived Factor 1;Substance Use Disorder;Surface;T-Lymphocyte;therapeutic target;therapy development;Tissues;Up-Regulation;Viral;Viral reservoir;Virus

PROJECT_TITLE: The impact of methamphetamine on CXCL12 mediated HIV neuropathogenesis

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Kidney Disease;Patient Safety;Precision Medicine;Prevention

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE To make informed surgical treatment decisions, older adults and the providers who care for them must weigh the long-term benefits of surgery against the short-term health risks for an individual patient. However, counseling on the tradeoffs of surgical intervention too often rely on population average risk rather than individualized estimates of risks/benefits. This research will create decision support for the management of primary hyperparathyroidism in older adults and, in doing so, establish a framework for how to combine individualized risk prediction with stakeholder feedback to develop surgical decision support that will inform treatment recommendations for older adults and reduce long-term morbidity.

PI_NAMEs: SEIB, CAROLYN DACEY (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Affect;Aging;aging related disease;Benefits and Risks;career;career development;Caring;Characteristics;Chronic Kidney Failure;Clinical;Clinical Trials;Communication;comparative effectiveness;Comparative Effectiveness Research;Counseling;Data;Decision Making;design;Development;Educational workshop;effectiveness/implementation trial;Elderly;Endocrine System Diseases;Endocrinologist;Ensure;evidence base;expectation;experience;Feedback;Focus Groups;Fracture;fracture risk;frailty;Funding;Future;Goals;Health;Hybrids;Hyperparathyroidism;implementation science;improved;Incidence;individual patient;individualized medicine;innovation;Institution;International;K-Series Research Career Programs;Kidney Calculi;Knowledge;Leadership;Medical;Methodology;Methods;Morbidity - disease rate;mortality risk;novel;older adult;operation;Operative Surgical Procedures;osteoporosis with pathological fracture;Outcome;Parathyroidectomy;patient oriented;Patient Selection;Patient-Centered Care;Patients;Perioperative;personalized care;personalized decision;personalized risk prediction;Population;Positioning Attribute;predictive modeling;predictive tools;prevent;Primary Care Physician;Procedures;programs;Provider;Recommendation;Research;Research Methodology;Research Priority;Risk;Risk Estimate;risk prediction;Risk Reduction;Severity of illness;skills;Standardization;support tools;Surgical Management;surgical risk;Testing;tool;Training;treatment center;treatment choice;treatment effect;Veterans Health Administration;Vulnerable Populations

PROJECT_TITLE: Developing a framework to individualize surgical decision-making for older adults with primary hyperparathyroidism


NIH_SPENDING_CATS: Genetics;Physical Injury - Accidents and Adverse Effects

PHR: Project Narrative: Trauma is a major public health crisis worldwide, and the number one leading cause of death from age 1 to 46. Neutrophils play a crucial pathological role in posttraumatic inflammatory response. Importantly, dysregulation of neutrophil responses and function due to pre-existent metabolic syndrome and associated metainflammation, contribute to increased susceptibility to develop posttraumatic complications in high-risk groups. Therefore, the goal of this work is to determine the mechanisms governing neutrophil responses in polytrauma in healthy and metainflammation conditions.

PI_NAMEs: DE OLIVEIRA, SOFIA  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Affect;Age;Animal Model;Animals;Cause of Death;Cessation of life;Chronic;Complex;Death Rate;disability;Disease;epigenetic profiling;Exhibits;fighting;Genetic;genetic manipulation;Goals;Health;high risk;high risk population;imaging approach;Immune System Diseases;Impairment;improved;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;Knowledge;Life;Lipids;Metabolic;Metabolic syndrome;migration;Modeling;Molecular;Multiple Organ Failure;Multiple Trauma;neutrophil;Neutrophil Infiltration;Nosocomial Infections;Optics;Pathologic;Patient-Focused Outcomes;Patients;Persons;pharmacologic;Phenotype;Play;Population;Predisposition;Process;Proteins;Public Health;Recovery;recruit;Research;response;Role;Sepsis;Site;systemic inflammatory response;Time;Tissues;Transcript;Trauma;Traumatic injury;Visualization;Work;Zebrafish

PROJECT_TITLE: Neutrophils in polytrauma – from recruitment to phenotypic and functional reprogramming

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Rare Diseases;Tuberous Sclerosis

ORG_CITY: MEMPHIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Project Narrative Early Communication in Tuberous Sclerosis Complex (TSC) and its Prediction of Autism will determine how key aspects of language development (early vocal development, fast-mapping, vocabulary development and shared attention) predict language outcome and autism severity. In the long term, this research will contribute fundamental knowledge about the significance of language in high-risk populations.

PI_NAMEs: GIPSON, TANJALA TRINETTE (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Age;auditory comprehension;Autism Diagnosis;autism diagnostic observation schedule;autism spectrum disorder;automated analysis;Award;Behavior;Centers of Research Excellence;Child;Child Development;Clinical;Code;Communication;Data;Data Set;Databases;Dedications;Development;Diagnosis;Early identification;Early Intervention;effective intervention;Environment;Epilepsy;Equipment and supply inventories;Evaluation;follow-up;Foundations;gaze;genetic testing;Goals;high risk;high risk population;Home;Human;Individual;Infant;insight;instrument;interest;joint attention;K-Series Research Career Programs;Knowledge;Laboratories;Language;Language Development;Language Development Disorders;Language Disorders;language outcome;Life;Longitudinal Studies;Maps;Measures;Mentors;Methods;Modeling;Neurobiology;non-verbal;Nursery Schools;Outcome;Outcome Measure;outcome prediction;Persons;Population;Procedures;programs;Psychosocial Factor;Recording of previous events;Reporting;Research;Role;Severities;shared attention;social;social communication;Standardization;Testing;Toddler;Tuberous Sclerosis;Video Recording;Vocabulary;vocalization;wearable device;word learning;Work

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Heightened experience of negative emotions, especially anxiety, are common in schizophrenia and cause significant distress and impairment; yet little is known about the underlying causes. This study will determine whether individuals with schizophrenia have alterations in the bed nucleus of the stria terminalis (BNST), a brain region that mediates anxiety in rodents, but is largely understudied in schizophrenia. Such knowledge is critical for identifying novel brain targets and guiding the development of new interventions to treat schizophrenia.

PI_NAMEs: FEOLA, BRANDEE ;WOODWARD, NEIL D. (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Acute;Amygdaloid structure;Animal Model;Anxiety;Anxiety Disorders;anxiety symptoms;Aversive Stimulus;Behavior;biological adaptation to stress;Brain;Brain region;Clinical;Cognition;common symptom;comorbidity;comparison control;conditioned fear;Data;Delusions;Detection;Development;Dimensions;Disease;Distress;Emotions;experience;Foundations;Fright;Functional Magnetic Resonance Imaging;Future;Galvanic Skin Response;Human;Hydrocortisone;Impairment;in vivo;Individual;Intervention;Knowledge;Maps;Measures;Mediating;Mental disorders;Methods;Modeling;Motor;Negative Valence;neurobiological mechanism;Neurobiology;neuroimaging;novel;Outcome;Paranoia;Pattern;Persons;Physiological;Physiology;Pilot Projects;Play;Prefrontal Cortex;Prevalence;Quality of life;Research;Research Domain Criteria;Resolution;response;Rest;Rodent;Role;Schizophrenia;Sensory;severe mental illness;Social Functioning;Stimulus;Structure of terminal stria nuclei of preoptic region;Subgroup;suicidal risk;Symptoms;System;Testing;Uncertainty

PROJECT_TITLE: Negative Valence Systems in Schizophrenia

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: HUNTSVILLE

ORG_NAME: CFD RESEARCH CORPORATION

PHR: This project addresses the critical need for a standardized platform which improves understanding of the placental barrier and enables prediction of transplacental drug transport. This study combines modeling approaches to create a whole picture of maternal and fetal exposure to drugs taken by a pregnant woman. These studies will aide in the safe and effective treatment of the medical needs of pregnant women, enabling the provision of guidelines for prescription of medications and open up the possibility of therapeutically treating fetuses by maternal administration.

PI_NAMEs: GERMAN, CARRIE  (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Acetaminophen;Active Biological Transport;Address;Anatomy;Antibodies;Automobile Driving;barrier to testing;Biological;Biological Assay;Blood Vessels;Calcium;Cell Death;Cell Line;cell type;Cells;Cellular Morphology;Chemicals;Circulation;Computer Models;cytotrophoblast;Data;Dependence;design;Development;Devices;Dextrans;Dimensions;Disadvantaged;Discipline of obstetrics;Drug Kinetics;Drug Prescriptions;Drug Transport;effective therapy;Endothelial Cells;Ethics;Evaluation;ex vivo perfusion;Exclusion;experience;experimental study;Exposure to;fetal;Fetus;Genetic;Genetic Complementation Test;Gestational Age;Goals;Guidelines;Health;Hormones;Human;Human body;Human Chorionic Gonadotropin;hydrophilicity;Immunoglobulin G;improved;in silico;In Vitro;in vitro Model;in vivo;in vivo evaluation;Inflammation;inorganic phosphate;Inulin;ionization;Lipids;lipophilicity;Literature;Maintenance;Maternal Exposure;Mediating;Medical;Medical center;Microfluidic Microchips;Microfluidics;Modeling;Morphology;Mothers;multidisciplinary;multiplex assay;Nutrient;Organ;oxygen transport;Palmitates;passive transport;Perfusion;Permeability;Pharmaceutical Preparations;pharmacokinetic model;Phase;phase 1 study;Phenotype;Physiological;Physiology;Placenta;Placental Biology;placental trophoblasts;Positioning Attribute;predictive modeling;Pregnant Women;prenatal exposure;Property;protein expression;Protocols documentation;prototype;Regulation;Reperfusion Therapy;Reporting;Research;Resolution;Role;Source;Standardization;success;Syncytiotrophoblast;System;Testing;Therapeutic;Third Pregnancy Trimester;Time;tool;Toxic effect;Toxin;treatment strategy;trophoblast;uptake;Vascular Endothelial Cell;Waste Products;Xenobiotics

PROJECT_TITLE: A synergistic in vitro-in silico model of the placental barrier for predicting fetal exposure and toxicity of xenobiotic compounds


NIH_SPENDING_CATS: Aging;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Increasing evidence implicates cellular metabolism as a key regulator of cell fate and function, however, little is known about how changes in cellular metabolism impact complex, high-energy demand processes such as skeletal regeneration. In this project we will test the influence of cellular metabolism on the regenerative process and its role in regenerative decline. Our results will provide valuable insight into the mechanisms that promote skeletal regeneration and will offer new insight into therapeutic targets to promote bone formation and healing.

PI_NAMEs: SAMMARCO, MIMI C (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Affect;Aging;Amputation;Biological;blastema;bone healing;Bone Regeneration;Cell Differentiation process;Cell Physiology;cell type;Cells;Cellular Metabolic Process;Collagen;Complex;Data;Deposition;Digit structure;Exhibits;Gene Expression;Genes;Genetic;Glycolysis;Hepatocyte;Homeostasis;Human;Impairment;inducible Cre;Injury;insight;Knockout Mice;Knowledge;limb regeneration;Link;Metabolic;Metabolism;mineralization;Minerals;Modeling;Molecular;mouse model;Mus;Natural regeneration;novel;old mice;osteoblast differentiation;Osteoblasts;Osteogenesis;Outcome;Oxaloacetates;Oxidative Phosphorylation;Pathway interactions;Process;progenitor;Proliferating;Protein Secretion;regenerative;Regenerative capacity;repaired;respiratory;response;Role;Salamander;Signal Transduction;skeletal;skeletal regeneration;stem cell proliferation;Structure;Testing;therapeutic target;Thick;Time;Tissues;transcriptomics;triple helix

PROJECT_TITLE: Cellular metabolism at the crossroads of skeletal regeneration

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Weight bias internalization (WBI) has been associated with a number of negative physical and mental health consequences for adolescents with obesity, including negative weight-related outcomes. This study will develop, adapt, and pilot test a combined treatment for WBI and behavioral weight control for adolescents, designed to improve WBI and mechanisms of weight stigma induced weight gain including biological markers of stress and inflammation, and dysregulated eating behaviors. Addressing WBI as a particularly salient and impactful psychosocial stressor could improve behavioral weight control outcomes and improve physical and psychological stress for adolescents with obesity.

PI_NAMEs: DARLING, KATHERINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: acceptability and feasibility;Address;Adolescence;Adolescent;adolescent health;adolescent health outcomes;Adolescent obesity;Adult;Aftercare;Age;Anxiety;Attitude;Award;Behavior Control;behavior test;Behavior Therapy;Behavioral Weight Control;Biological Markers;Body mass index;Body Weight decreased;C-reactive protein;Calories;Child;Clinical;Clinical Trials;cohort;Combined Modality Therapy;Consumption;coping;critical developmental period;critical period;Data;Dedications;design;Development;Diabetes Mellitus;Eating Behavior;Eating Disorders;Effectiveness;emotional eating;Environment;evidence base;experience;Exposure to;Fatty acid glycerol esters;feasibility testing;Feedback;Focus Groups;Goals;Health;Heterogeneity;Hospitals;Hydrocortisone;Hypothalamic structure;improved;Inflammation;Interleukin-6;Intervention;intervention effect;intervention refinement;Intervention Trial;K-Series Research Career Programs;Knowledge;loss of control over eating;Maps;Mental Depression;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Modeling;novel;Obesity;obesity treatment;Outcome;Overweight;Pathway interactions;Periodicity;Phase;Phase Ia Trial;physical conditioning;Physiological;pilot test;pilot trial;Pituitary Gland;Prevalence;Psychological Stress;psychological stressor;psychosocial stressors;Published Comment;Qualifying;Randomized;Randomized, Controlled Trials;Research;Research Personnel;Research Project Grants;research study;response;Risk;Self Direction;Self-Examination;skills;social stigma;standard care;Stress;stressor;Structure;systemic inflammatory response;Testing;therapy development;Training;Training Programs;Universities;verbal;Weight;Weight Gain;Weight maintenance regimen;Youth

PROJECT_TITLE: Addressing Weight Bias Internalization to Improve Adolescent Weight Management Outcomes

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_CITY: SEATTLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PUBLIC NARRATIVE. Psychosocial clinical interventions are the preferred mode of treatment for most people seeking care for mental health problems – particularly among people of color and those living in poverty in both rural and urban communities – but very few people have access to them because of the problems with usability, contextual fit, and engagement experienced when those interventions and the implementation strategies designed to support their use are deployed in accessible settings like primary care medicine and schools. The UW ALACRITY Center will address these issues by advancing its novel framework for redesigning clinical interventions and implementation strategies, drawing from the fields of human-centered design and implementation science. Across projects, the UW ALACRITY team will work with local practitioners and other stakeholders to develop and test four new solutions for addressing problems in the usability, contextual fit, and engagement of clinical interventions and implementation strategies in primary care and schools and will support additional pilot studies over the 5-year timeline.

PI_NAMEs: LYON, AARON ROBERT (contact);MUNSON, SEAN

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Address;Alaska;autism spectrum disorder;Behavior Therapy;brief intervention;care seeking;career;Case Management;Characteristics;Client;Clinic;Clinical;clinical implementation;Cognitive Therapy;collaborative care;college;Color;Communication;Communities;computer science;Consultations;cost;Cost Analysis;Counseling;Data;Data Analyses;design;design,build,test;Development;Discipline;Discover, Design, Build, and Test Framework;Education;effective intervention;Engineering;Ethnic Population;Evaluation;evidence base;experience;Face;Family Practice;Feedback;Fostering;Future;Goals;Grant;Guidelines;health assessment;human centered design;Idaho;implementation facilitation;implementation outcomes;implementation science;implementation strategy;improved;Incentives;innovation;Institute of Medicine (U.S.);Interdisciplinary Study;Intervention;Intervention Studies;Learning;Libraries;Low income;medical schools;Medicine;meetings;Mental Health;Mental Health Services;Mentors;Methodology;Methods;Minority Groups;Modeling;Modification;Montana;multidisciplinary;novel;Oregon;Outcome;Patient Outcomes Assessments;Patient Self-Report;Patient-Focused Outcomes;people of color;Perinatal;Persons;Pilot Projects;Poverty;Primary Care;primary care clinic;primary care practice;Primary Schools;Problem Solving;Process;prospective;Protocols documentation;Psychiatry;Psychology;psychosocial;Psychotherapy;Public Health Schools;racial population;Reporting;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Rural Community;Rural Population;rural setting;safety net;school district;Schools;Science;Service setting;Services;Site-Directed Mutagenesis;Social Work;Students;success;support tools;synergism;Testing;timeline;Trainers Training;Training;translational health science;Translational Research;Trauma;Triage;Typology;underserved community;United States National Institutes of Health;Universities;Update;uptake;Urban Community;usability;Washington;web site;Work;Wyoming;X Inactivation;Youth

PROJECT_TITLE: UW ALACRITY Center for Psychosocial Interventions Research


NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;Mental Health;Prevention;Primary Health Care;Social Determinants of Health

PI_NAMEs: LYON, AARON ROBERT (contact)

PROJECT_TERMS: Address;Adopted;Adult;Alaska;analytical method;Applications Grants;Area;Attention;Award;career;Clinical;clinical implementation;Collaborations;Communication;Communities;community partners;Community Practice;community setting;Consultations;Data;Data Analytics;Data Collection;Decision Making;design;Disadvantaged;Discipline;Discover, Design, Build, and Test Framework;Education;education resources;Effectiveness;Ensure;Evaluation;Faculty;Feedback;Female;Fostering;Funding;Future;Goals;graduate student;Grant;human centered design;Human Resources;Idaho;implementation science;implementation strategy;improved;Incubators;innovation;Interdisciplinary Study;International;Intervention;Intervention Studies;Lead;Leadership;Learning;marginalized population;meetings;member;Mental Health;Mentors;Mentorship;Methods;Modeling;Modification;Montana;multidisciplinary;National Institute of Mental Health;novel;operation;Participant;Pilot Projects;Policies;Postdoctoral Fellow;Primary Care;Primary Schools;Process;process evaluation;programs;psychosocial;Public Health;Publications;Request for Proposals;Research;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Research Support;Schools;Science;Strategic Planning;success;synergism;System;Technology Transfer;Time;Translating;translational engagement;Translational Research;United States National Institutes of Health;Universities;usability;Washington;web site;Work;Wyoming;X Inactivation;Youth

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative We seek to understand how metabolic networks connect with the development of antimicrobial resistance. The collaboration of a highly complementary group of investigators with expertise in metabolic network modeling, bacterial physiology, and infectious disease will support the proposed studies. The proposed experiments and computational modeling will lead to greater understanding of the development of antimicrobial resistance and thus catalyze the development of new therapeutic strategies to tackle this important clinical challenge.

PI_NAMEs: PAPIN, JASON  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;antimicrobial resistant pathogen;Bacteria;Bacterial Physiology;bacterial resistance;Biochemical Pathway;Cell Membrane Permeability;chronic wound;Clinical;clinical phenotype;clinically relevant;Collaborations;combat;Communicable Diseases;Complex;Computer Models;Data;Dependence;Development;Drug resistance;efflux pump;emerging antimicrobial resistance;Environment;Essential Genes;Evolution;Experimental Models;experimental study;Gene Expression;Genes;Genomics;Growth;human pathogen;Infection;Knowledge;Link;Lung;machine learning method;Metabolic;Metabolism;Methods;Microbe;microbial;microorganism;Modeling;multiple omics;Mutation;network models;Nosocomial Infections;novel strategies;novel therapeutic intervention;Opportunistic Infections;opportunistic pathogen;Organism;pathogen;Pathway interactions;Phenotype;phenotypic data;Physiological;Population;predictive modeling;preference;Pseudomonas aeruginosa;Reaction;reconstruction;Research Personnel;Resistance;resistance mechanism;resistant strain;Site;Staphylococcus aureus;System;Systems Biology;Testing;therapeutic target;transcriptomics;Uncertainty;United States;uptake;Urinary tract;Validation;Work

PROJECT_TITLE: Systems biology approach to elucidate complex metabolic dependencies in the evolution of antibiotic resistance

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Dissemination and Implementation Research;Mental Health;Prevention;Social Determinants of Health

PI_NAMEs: PULLMANN, MICHAEL DAVID (contact)

PROJECT_TERMS: Address;Adherence;Adoption;Affect;Attitude;care recipients;Catalogs;Client;Climate;Clinical;Collaborations;Communities;community organizations;community partners;comparative;Consolidated Framework for Implementation Research;Consultations;cost;Cost Analysis;Data;Data Analyses;Data Collection;design;Discover, Design, Build, and Test Framework;effectiveness/implementation study;effectiveness/implementation trial;equity, diversity, and inclusion;evidence base;Evidence based intervention;Face;Funding;Future;Health Resources;human centered design;implementation outcomes;implementation science;implementation strategy;improved;Individual;innovation;integrated care;Intention;Intervention;Intervention Studies;iterative design;Leadership;Libraries;Medicine;Meta-Analysis;Methodology;Methods;Modification;novel;Outcome;Output;Patient-Focused Outcomes;Phase;Pilot Projects;Population;Primary Care;Process;Progress Reports;prospective;psychosocial;Reporting;Research;Research Activity;research faculty;Research Personnel;Research Project Grants;Research Support;Resources;Rest;Schools;shared decision making;Site-Directed Mutagenesis;Standardization;Structure;Supervision;Teacher Professional Development;Technology;Testing;theories;Training;Typology;Universities;Update;usability;Washington;Work

PROJECT_TITLE: Methods Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Neurosciences;Opioids

ORG_CITY: MILWAUKEE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Depression of breathing from opioids, often in combination with other sedative drugs, has become a major public health problem. We have identified the areas within the breathing center in the brainstem that are most affected by these drugs. This study proposes to use a rabbit model to determine which drugs are best suited to stimulate these areas, and how completely this stimulation can offset the decrease in breathing caused by opioids and other drugs.

PI_NAMEs: STUCKE, ASTRID G (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Absence of pain sensation;Acute;Adult;Affect;AMPA Receptors;Analgesics;Anesthesia procedures;Animals;antagonist;Apnea;Area;Benzodiazepines;Brain Stem;Breathing;Carbon Dioxide;Cell Nucleus;Clinical;Complex;Data;Decerebration procedure;Development;Dose;drug development;effectiveness evaluation;expiration;Fentanyl;Frequencies;Generations;Glutamate Receptor;Glutamates;Goals;Human;Hypoxia;improved;In Vitro;in vivo;Infusion procedures;Injury;insight;Intravenous;Ketamine;Location;Measures;Mediating;Mental Depression;Microinjections;Minor;Modeling;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Naloxone;Neurons;novel;Opiate Addiction;Opioid;Opioid Antagonist;opioid injection;Oryctolagus cuniculus;overdose death;parabrachial nucleus;Pattern;Perioperative;Pharmaceutical Preparations;Phase;Physiological;Play;Postoperative Period;preBotzinger complex;Preparation;prevent;Public Health;Publishing;Reflex action;respiratory;response;Risk;Risk Factors;Role;sedative;Site;Synapses;Testing;Therapeutic;Tidal Volume;Ventilatory Depression;Withdrawal

PROJECT_TITLE: Mechanisms of opioid and sedative-induced respiratory depression

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Liver Disease

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative The vast majority of patients with metastatic colorectal cancer (CRC) cannot be cured, mainly due to a lack of understanding and therapeutics to target the underlying metastatic process. A significant barrier for metastasis research is recapitulating the complex biology in a suitable model system. This proposal aims to utilize state-of- the-art CRC organoids and orthotopic mouse models to understand the CRC metastatic process better, informing future research into therapeutics to improve the survival and quality of life for individuals with CRC.

PI_NAMEs: SEDLAK, JOSEPH CHARLES (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: 3-Dimensional;Ablation;Basement membrane;Biological Assay;Biological Models;Biology;Cancer Biology;cancer cell;Cancer Etiology;Cancer Model;CDH1 gene;Cell Adhesion;Cell Communication;Cells;Cessation of life;Circulation;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Colon;colon cancer patients;Colonoscopy;Colorectal Cancer;colorectal cancer metastasis;colorectal cancer progression;Complementary DNA;Complex;CRISPR/Cas technology;Development;differential expression;Diphtheria;diphtheria toxin receptor;Distant;Engineering;Environment;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Evaluation;Extravasation;Future;Genetic Engineering;Genotype;Harvest;Human;Human Engineering;Immunocompromised Host;Immunodeficient Mouse;Immunohistochemistry;improved;In Situ Hybridization;In Vitro;in vivo Model;Individual;insight;Invaded;Knock-out;Knowledge;Link;Literature;Liver;loss of function;Mediating;Mesenchymal;metastatic colorectal;Metastatic Neoplasm to the Liver;metastatic process;migration;Modeling;mortality;Motility;mouse model;Mus;Mutation;Neoplasm Metastasis;novel therapeutics;Oncogenic;Organ;organoid transplantation;Organoids;Outcome;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;physiologic model;Play;post-transplant;prevent;Primary Neoplasm;Process;Quality of life;receptor;Receptor Cell;Research;Role;Sampling;Site;Stains;Testing;Therapeutic;Therapeutic Intervention;Tissue Microarray;Tissues;TP53 gene;transcription factor;transplant model;Transplantation;tumor;TWIST1 gene;United States;Work

PROJECT_TITLE: Understanding the role of TWIST1 in colorectal cancer progression and metastasis


ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) and cerebral amyloid angiopathy (CAA) are significant contributors to age-related dementia and a major economic burden. These diseases result, at least in part, by the abnormal accumulation of toxic proteins in the brain and harnessing the power of our immune system has significant potential to enhance their removal, reducing, or even preventing, cognitive decline. Here we focus on a largely neglected population of immune cells situated in the borders surrounding the brain and explore how these cells communicate with other central nervous system clearance routes, particularly the meningeal lymphatics that drain the cerebrospinal fluid, to facilitate the removal of these toxic proteins, thus highlighting a novel therapeutic target for AD and CAA.

PI_NAMEs: KIPNIS, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: abeta accumulation;Address;Affect;age related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease related dementia;Amyloid beta-Protein;Animal Model;Apolipoprotein E;Area;Basic Science;beta amyloid pathology;Bioinformatics;Biology;Blood - brain barrier anatomy;Blood Circulation;Blood Vessels;blood-brain barrier function;Brain;Brain Diseases;brain endothelial cell;Cell Communication;Cells;Central Nervous System;Cerebral Amyloid Angiopathy;Cerebrospinal Fluid;Cerebrovascular system;Cholesterol Homeostasis;clinical translation;Collaborations;Collection;Complex;cost;cranium;Data;Dementia;Discipline;Disease;Disease Progression;Economic Burden;Engraftment;Event;Excision;fluid flow;Functional disorder;Future;healing;High Density Lipoproteins;Human;Image;imaging approach;Immune;Immune system;Immune Targeting;Immunologist;Immunotherapy;Impaired cognition;in vivo;Innate Immune Response;Innate Immune System;innovation;Intercellular Fluid;interdisciplinary approach;intravital imaging;Knowledge acquisition;Leptomeninges;Link;Lymphatic;lymphatic drainage;Macrophage;Meningeal lymphatic system;Microglia;misfolded protein;Mission;multidisciplinary;Myeloid Cells;National Institute on Aging;Natural Immunity;neglect;Nerve Degeneration;Neurodegenerative Disorders;Neuroimmune;neuroimmunology;Neurons;Neurosciences;new therapeutic target;novel;novel therapeutic intervention;Operative Surgical Procedures;Pathologic;Pathology;Pathway interactions;Patients;Persons;Phagocytosis;Population;pre-clinical;prevent;Probability;programs;protein aggregation;Proteins;Publications;Research;Role;Route;Senile Plaques;Severity of illness;Signal Transduction;SYK gene;synergism;Technology;Therapeutic;therapeutic target;tool;Transgenic Mice;Transplantation;TREM2 gene;Vascular Diseases;wasting

PROJECT_TITLE: Neuroimmunology of AD and CAA with focus on innate immunity and lymphatics


NIH_SPENDING_CATS: Aging;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences

PROJECT_TERMS: Big Data;Bioinformatics;Cells;cloud platform;Communication;Communities;Data;Data Analyses;data dissemination;data management;data repository;data resource;Data Set;data sharing;digital;Ensure;experimental study;Fostering;Future;Image;Imagery;Individual;International;Knowledge;Laboratories;Logistics;Lymphatic;meetings;member;Microscopy;Natural Immunity;neuroimmunology;online repository;operation;Operative Surgical Procedures;programs;Proteomics;Research;Research Project Grants;Resources;Schedule;Secure;Security;symposium;System;transcriptome sequencing;Universities;Visualization;Washington


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Patient Safety;Primary Health Care;Social Determinants of Health

PI_NAMEs: BENNETT, IAN MOORE (contact)

PROJECT_TERMS: Adoption;Aftercare;Automated Clinical Decision Support;Behavioral;care delivery;Caring;Certification;Client;Clinic;Clinical;clinical care;Clinical Decision Support Systems;Collaborations;Communities;Data;depressive symptoms;design;Development;Disease;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Electronic Health Record;Elements;Ensure;Ethnic Origin;evidence base;Evidence based intervention;experience;Feedback;functional improvement;Goals;Health;Hour;Hybrids;implementation outcomes;implementation strategy;implementation/effectiveness;improved;Intervention;Intervention Studies;Low income;Measures;Mediating;Mental Depression;Modeling;Neighborhood Health Center;network informatics;Outcome;Patient-Focused Outcomes;Patients;Phase;Primary Care;primary care setting;Problem Solving;Procedures;Process;psychosocial;Public Health Informatics;Quality of life;racial diversity;Randomized;randomized trial;randomized, clinical trials;recruit;Reporting;response;Self Efficacy;shared decision making;success;Supervision;support tools;System;Technology;Testing;Time;tool;Training;treatment adherence;treatment as usual;Treatment Effectiveness;trial comparing;usability;web app;Work

PROJECT_TITLE: Type III Hybrid Effectiveness-Implementation Trial of a Clinical Decision Support System for the Implementation of Problem Solving Treatment in Community Health Centers


PI_NAMEs: RANDOLPH, GWENDALYN J (contact)

PROJECT_TERMS: Antibodies;Behavior;Biology;Blood flow;Blood Vessels;Brain region;Cells;central nervous system vasculature;Collaborations;Color;combinatorial;Coupled;cranium;Data;Data Analyses;Data Set;Diameter;Erythrocytes;experience;Grant;High Density Lipoproteins;Image;Image Analysis;Image-Guided Surgery;Immune;improved;indexing;Individual;innovation;intravital imaging;Laboratories;light microscopy;Lipoproteins;Lymphatic;lymphatic vasculature;Macrophage;Meningeal;Meninges;Methods;Modality;Molecular;mouse model;Natural Immunity;neuroimmunology;novel;Operative Surgical Procedures;Oxygen;oxygen transport;Pathogenesis;Pathology;Penetration;photoacoustic imaging;Procedures;programs;protocol development;Reagent;Refractory;Research;Research Personnel;Resolution;Role;Sampling;Science;Services;skills;Speed;Stains;Standardization;Surgeon;Technology;Thinness;Three-Dimensional Imaging;tissue fixing;Tissue imaging;Tissues;tool;Tracer;trafficking;Transplantation;two photon microscopy;two-photon

PROJECT_TITLE: Imaging and Surgery Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Lymphatic Research;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PROJECT_TERMS: abeta deposition;Ablation;Age;age effect;Age related pathologies;aged;Aging;aging related;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloidosis;Antibodies;apolipoprotein E-4;Biology;Blood Vessels;Bone Marrow;Bone Marrow Cells;Brain;brain parenchyma;Cells;Central Nervous System;Central Nervous System Diseases;Cerebral Amyloid Angiopathy;Cerebrospinal Fluid;cerebrospinal fluid flow;Collaborations;cranium;cytokine;Data;Deposition;Dichloromethylene Diphosphonate;Diffusion;driving force;Exhibits;Extracellular Matrix;Extracellular Matrix Proteins;Functional disorder;Genetic;glymphatic system;Image;imaging approach;Immune System Diseases;Impairment;improved;Inflammatory;Injections;Injury;Invaded;Knock-in Mouse;Leptomeninges;Link;Liposomes;Location;Lymphatic;lymphatic vessel;Macrophage;Macrophage Activation;Macrophage Colony-Stimulating Factor;Mediator;Meningeal lymphatic system;Messenger RNA;Methods;Microglia;monocyte;mouse model;Mus;Myeloid Cells;Natural Immunity;Nerve Degeneration;Nervous System Disorder;Neuroimmune;neuroimmunology;neuroinflammation;new therapeutic target;normal aging;novel;old mice;Operative Surgical Procedures;Pathology;Penetration;permissiveness;pharmacologic;Phenotype;Physiology;Population;prevent;pro-aging;Process;programs;Role;Testing;theories;Therapeutic;Therapeutic Intervention;therapeutic target;Transgenic Mice;Transplantation;Traumatic Brain Injury;Treatment Factor;TREM2 gene;Vaccination;vasomotion

PROJECT_TITLE: Parenchymal border macrophages in AD and CAA


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed basic research project is relevant to public health because it aims to elucidate the role of interorgan crosstalk in the development of a wide variety of concurring immunometabolic pathologies. By employing advanced models of human multiorgan physiology, we are investigating how migratory immune cells, namely MR1-restricted lymphocytes, inform the origins and progression of inflammatory diseases that span multiple organ systems such as the gut-liver axis. Gained fundamental knowledge will be used to identify tangible targets for disease prevention and amelioration across a range of different pathologies.

PI_NAMEs: TRAPECAR, MARTIN  (contact)

PROJECT_TERMS: Affect;Antigens;Area;Autoimmune;Autoimmune Diseases;Autoimmune Hepatitis;Basic Science;Behavior;Biological;Body System;Cells;Circulation;Complex;computerized tools;Development;Disease;disorder prevention;Goals;gut-liver axis;Heterogeneity;Homeostasis;Human;human model;Immune;Inflammatory;Inflammatory Bowel Diseases;insight;Insulin-Dependent Diabetes Mellitus;Knowledge;Liver;Lymphocyte;Metabolic;Metabolic Diseases;microbial;microphysiology system;Modeling;Molecular;Mucous Membrane;multiple omics;Multiple Sclerosis;Neurodegenerative Disorders;Organ;Pathology;Physiology;Public Health;receptor;Research Project Grants;Resolution;Role;Shapes;Systems Biology;T-Lymphocyte;Tissue Donors;Tissues;tool;Ulcerative Colitis

PROJECT_TITLE: Uncovering the hidden universe of metabolite-specific T lymphocytes,using human multiorgan microphysiological systems.


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

PHR: Project Narrative Inflammasomes have been implicated in the detection and clearance of a variety of bacterial pathogens, but little is known about whether there is active cross-talk between the host sensing mechanism and the expression of stimulatory ligands by the pathogen. In this proposal we will investigate a host cell-intrinsic innate regulatory circuit involving NLRC4 inflammasome activity, lipid biosynthesis and type 1 interferons that regulates the temporal switch of Salmonella from a flagellin-high to a flagellin-low phenotype inside macrophages. Our investigations will identify how NLRC4 inflammasome activity modulates temporal and biphasic expression of its own microbial ligand, and reveal a host mechanism that has been has adapted by Salmonella for flagellin downregulation and immune escape inside macrophages.

PI_NAMEs: SUBRAMANIAN, NAEHA  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TITLE: Host innate immune mechanisms control temporal expression of flagellin by pathogenic Salmonella

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Immunotherapy;Lymphatic Research;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: HOLTZMAN, DAVID M. (contact)

PROJECT_TERMS: Abeta clearance;abeta deposition;Ablation;Affect;age related;Alzheimer's Disease;Alzheimer's disease model;Amyloid;Amyloid beta-Protein;Amyloid deposition;amyloid pathology;amyloidogenesis;Antibodies;Antibody Therapy;Apolipoprotein E;apolipoprotein E-4;Area;arteriole;Astrocytes;Blood flow;Blood Vessels;Brain;brain parenchyma;cell type;Cells;Cerebral Amyloid Angiopathy;Cerebrovascular system;Collaborations;Deposition;Development;Diameter;Edema;Elderly;Excision;experimental study;Fibroblasts;Gene Expression;Genetic;Genotype;gliovascular;Goals;Grant;Hemorrhage;High Density Lipoproteins;Hypercapnia;Image;Imaging Techniques;Immune;Immune response;Immune system;Immunotherapy;Impaired cognition;Impairment;improved;Individual;Inflammation;Ischemia;Leptomeninges;Link;Liquid substance;Lymphatic;Lymphatic function;Macrophage;Meningeal;Meningeal lymphatic system;Methods;Microglia;Modeling;mouse model;Mus;Myeloid Cells;Natural Immunity;Nerve Degeneration;neuroimmunology;Operative Surgical Procedures;Passive Immunotherapy;Pathogenesis;Pathologic;Pathology;Pericytes;Play;Population;Post-Translational Protein Processing;Reporting;response;Risk;Role;Senile Plaques;side effect;single-cell RNA sequencing;Smooth Muscle Myocytes;transcriptome;Vascular Diseases;Vascular Endothelial Growth Factor C;vascular inflammation;Vascular Smooth Muscle

PROJECT_TITLE: Cerebral amyloid angiopathy: Role of ApoE, innate immunity, and meningeal lymphatics


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Social Determinants of Health

PI_NAMEs: LOCKE, JILL J (contact)

PROJECT_TERMS: Address;adolescent with autism spectrum disorder;Adoption;Affect;autism spectrum disorder;autistic;autistic children;Behavior;Behavior Therapy;Behavioral;behavioral health;behavioral outcome;Calendar;caregiver education;Characteristics;Child;Child Behavior;Clinical;Communities;Consultations;contextual factors;Country;COVID-19;Data;design;Deterioration;Discover, Design, Build, and Test Framework;economic cost;Education;Educational Intervention;Educational process of instructing;Effectiveness;elementary school;empowerment;Ensure;Evaluation;evidence base;Evidence based intervention;Evidence based practice;Exposure to;Financial cost;Funding;Future;Glean;implementation design;implementation intervention;implementation outcomes;implementation strategy;implementation trial;improved;Individual;Intervention;Intervention Studies;Interview;Knowledge;Learning;Manuals;medical specialties;meetings;Mental Health;Methods;mobile application;Modification;Names;National Institute of Mental Health;Neurodevelopmental Disorder;Outcome;parenting intervention;Participant;Persons;Phase;practice factors;Preparation;Prevalence;Primary Schools;prototype;Provider;psychosocial;public education;Public Health;Quality of life;Research;Research Design;Research Support;Resources;Schools;Site-Directed Mutagenesis;skills;Students;teacher;Technology;Testing;Theory of Change;Training;United States;United States National Institutes of Health;Universities;uptake;usability;Washington

PROJECT_TITLE: Iterative Redesign of a Multifaceted Implementation Strategy for a School-based Behavioral Skills Intervention


NIH_SPENDING_CATS: Breast Cancer;Breastfeeding, Lactation and Breast Milk;Cancer;Immunotherapy;Maternal Health;Maternal Morbidity and Mortality;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: We will test the hypothesis that SEMA7A expression drives cellular survival during post-lactational mammary gland involution to regenerate a lactation competent epithelium for multiple rounds of lactation. We will also analyze mechanisms of immunosuppression generated by SEMA7A signaling during involution and how aberrant expression of SEMA7A after the period of postpartum involution may contribute to cellular transformation and subsequent malignancy in postpartum women.

PI_NAMEs: LYONS, TRACI  (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Affect;Age;Anoikis;Apoptosis;Autoantigens;Basement membrane;Biological Response Modifiers;Biology;Birth;Breast Cancer Cell;breast cancer diagnosis;Breast Cancer Patient;Breast Cancer Risk Factor;Breast Epithelial Cells;breast malignancies;Cell Compartmentation;Cell Death;Cell Survival;Cells;Cessation of life;Chemotaxis;Child;child bearing;Childbirth;Chronic;clinically relevant;Color;Data;defined contribution;Development;Diagnosis;Elderly;Endothelial Cells;Epithelial Cells;Epithelium;Exhibits;experience;Extracellular Matrix;First Births;functional plasticity;Gene Expression Profiling;Gland;Goals;Immune;immune activation;immune clearance;Immune system;Immune Tolerance;Immunologic Surveillance;immunoregulation;Immunosuppression;in vivo;insight;Integrins;Knockout Mice;Lactation;Length;Lymphatic;Lymphatic Endothelial Cells;Macrophage;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;mammary epithelium;Mammary gland;mammary gland development;Mammary Gland Parenchyma;Mediating;metaplastic cell transformation;Modeling;Modernization;monocyte;Mus;Natural regeneration;neoplastic cell;Neuroimmune;Neurons;novel;Phase;Population;postnatal development;postpartum breast cancer;Postpartum Period;Postpartum Women;Predisposition;Pregnancy;prevent;programmed cell death ligand 1;programmed cell death protein 1;protective effect;receptor;recruit;Resistance;Risk;Role;Semaphorins;Signal Transduction;stem cell population;stem cells;suckling;T-Lymphocyte;Testing;Time;Tissues;trafficking;tumor;tumorigenic;Up-Regulation;Woman;young woman

PROJECT_TITLE: SEMA7A in postpartum mammary gland development and cellular transformation

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Lymphatic Research;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PROJECT_TERMS: abeta deposition;Address;Affect;Alzheimer's Disease;Amyloid beta-Protein;apolipoprotein E-4;arteriole;ATP binding cassette transporter 1;Behavior;Bile fluid;Blood;Blood Circulation;Blood flow;Blood Vessels;blood-brain barrier crossing;Brain;brain parenchyma;Cell membrane;Cells;Cerebral Amyloid Angiopathy;Cerebral hemisphere hemorrhage;Cholesterol;Chronic;confocal imaging;Coupling;cranium;Data;Dendritic Cells;Deposition;Disease;Disease Progression;Endocytosis;epidemiology study;Experimental Models;Genetic;Health;High Density Lipoproteins;Hour;Human;Image;Impairment;improved;interest;interstitial;intravital imaging;Investigational Therapies;Knock-in Mouse;Laboratories;Leptomeninges;Lesion;Light;Link;Lipoproteins;Liquid substance;Literature;Liver;Lymph;lymph flow;Lymphatic;lymphatic circulation;lymphatic vasculature;Macrophage;Mediating;Mediator;Membrane Transport Proteins;Meningeal;Meningeal lymphatic system;Meninges;Modeling;monocyte;mouse model;Mus;Natural Immunity;neuroimmunology;Organ;Penetration;Peptides;Phagocytosis;Phenotype;Plasma;porcine model;Process;Proteins;restraint;reverse cholesterol transport;Role;Signal Transduction;Site;spatial relationship;Testing;Therapeutic Intervention;Thinness;Tissues;tool;trafficking;Tunica Adventitia;two-photon;Vascular Diseases;vascular inflammation;β-amyloid burden

PROJECT_TITLE: Interplay between meningeal lymphatics, high-density lipoproteins and border macrophages in cerebral amyloid angiopathy


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: COLONNA, MARCO  (contact)

PROJECT_TERMS: abeta accumulation;Abeta clearance;Affect;Age;aged;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;amyloid pathology;Antibodies;Apolipoprotein E;apolipoprotein E-4;Attenuated;Autophagocytosis;Behavior;beta amyloid pathology;Biochemistry;Black Box;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;brain tissue;C Type Lectin Receptors;Candidate Disease Gene;Cerebral Amyloid Angiopathy;Cerebrovascular system;Collaborations;Comprehension;Cytoplasm;Data;Defect;Dementia;Disease associated microglia;Disease Progression;DNA;DNA Sequence Alteration;Endothelial Cells;experimental study;extracellular;Extracellular Matrix;FRAP1 gene;Genes;Genetic;genetic risk factor;Genetic study;Hemorrhage;high risk;Human;Hypercapnia;Impairment;Individual;Innate Immune Response;Intervention;ITAM;Laboratories;Late Onset Alzheimer Disease;Leptomeninges;Ligands;lipid metabolism;Lipids;Lymphatic;Macrophage;Maintenance;Mediator;Membrane;Memory impairment;Metabolic;metabolomics;Microglia;Modeling;Monoclonal Antibodies;mouse model;Mus;Natural Immunity;Nerve Degeneration;Neurites;Neurofibrillary Tangles;neuroimmunology;neuron loss;new therapeutic target;novel therapeutics;Pathologic;Pathology;Pathway interactions;Phenotype;photoacoustic imaging;PIK3CG gene;Play;preservation;Production;Proliferating;Protein Tyrosine Kinase;receptor;receptor expression;recruit;Regulation;response;Role;Senile Plaques;Signal Transduction;Surface;SYK gene;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;transmission process;TREM2 gene;two photon microscopy;TYROBP gene;Tyrosine Phosphorylation;Variant;vasoconstriction;vasomotion

PROJECT_TITLE: The protein tyrosine kinase SYK drives innate immune responses against Alzheimer's Disease


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

PHR: PROJECT NARRATIVE This proposal is aimed at studying the role of OFC circuits in alcohol consumption and seeking. To this end, we will use cutting-edge imaging techniques to longitudinally image neuronal circuits in OFC. Completion of these aims will likely yield major insights into how a critical node of dysfunction in alcohol use disorder processes al- cohol consumption and seeking.

PI_NAMEs: K NAMBOODIRI, VIJAY MOHAN  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: alcohol behavior;Alcohol consumption;alcohol cue;alcohol memory;alcohol response;alcohol reward;alcohol seeking behavior;alcohol use disorder;Alcohols;Animals;Association Learning;Behavior;Brain;Calcium;Cells;Chronic;Corpus striatum structure;Cues;Decision Making;Development;Dorsal;drug of abuse;drug reward;Evolution;Extinction;Functional disorder;Head;Home;Hour;Image;Imaging Techniques;insight;interest;Investigation;Label;Learning;learning extinction;Longitudinal Studies;Mediating;Memory;Mental disorders;motivated behavior;mouse model;Mus;Nature;neuronal circuitry;Neurons;optogenetics;Output;Population;preference;Process;Quinine;Relapse;Research;Resistance;Resolution;response;Rewards;Role;Self Administration;serial imaging;Site;Sucrose;Technology;Testing;therapeutically effective;Time;two-photon;Ventral Striatum;Ventral Tegmental Area;Water

PROJECT_TITLE: Orbitofrontal circuit mechanisms underlying alcohol use disorder

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative The rapid advances in genome technologies and medical informatics have helped investigators generate huge amount of biological and biomedical data, including genome-wide DNA variation, tissue-specific gene expression, functional genomic annotations, and electronic medical records. To effectively mine such highly dimensional and heterogeneous datasets, we will develop novel computational methods to assess the functional impact of genetic variants in the human genome and study the genetic architecture of complex disease and traits at the regulatory, spatial, temporal, and single cell levels.

PI_NAMEs: ZHAO, ZHONGMING  (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: 3-Dimensional;Affect;Automobile Driving;biobank;Bioinformatics;Biological;Brain Diseases;Cell Physiology;cell type;Cells;Code;cohort;Communities;Complex;Computerized Medical Record;computerized tools;Computing Methodologies;Data;data mining;Data Science;Data Set;Databases;deep learning;Development;Disease;disease phenotype;disorder risk;DNA;Elements;Environmental Risk Factor;Epigenetic Process;epigenomics;functional genomics;gene environment interaction;Gene Expression;gene interaction;Genes;Genetic;genetic architecture;Genetic study;Genetic Transcription;genetic variant;Genome;genome annotation;genome wide association study;genome-wide;genomic data;Genomics;Genotype;Genotype-Tissue Expression Project;heterogenous data;high dimensionality;Human;Human Genome;human study;Individual;Informatics;innovation;Link;Maps;Medical Informatics;Methods;Mining;mRNA Expression;Multiomic Data;neural network;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuropsychiatric disorder;novel;Other Genetics;Phenotype;phenotypic data;Play;Population;programs;Proteins;Regulation;Reporting;Research;Research Personnel;Resolution;Role;Sampling;Signal Transduction;single cell sequencing;Single Nucleotide Polymorphism;single-cell RNA sequencing;spatiotemporal;Statistical Methods;Technology;Tissue-Specific Gene Expression;Tissues;trait;transcriptome;Untranslated RNA;Variant;web server

PROJECT_TITLE: Predicting Phenotype by Deep Learning Heterogeneous Multi-Omics Data

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Comprehensive-Tele-Harm Reduction (C-THR) seeks to engage people who inject drugs (PWID) into comprehensive HIV prevention services by deconstructing the traditional healthcare system and leveraging syringe services programs as trusted venues to deliver telehealth-enhanced access to PrEP, medications for opioid use disorder (MOUD), hepatitis C (HCV) cure, and treatment for bacterial and sexually transmitted infections. We urgently need a strong evidence base to prove that Comprehensive-Tele-Harm Reduction can help us prevent HIV and save lives. We seek to set the foundation to build, implement, and scale-up a new standard of care for comprehensive HIV prevention and treatment in PWID.

PI_NAMEs: BAROCAS, JOSHUA ADAM;BARTHOLOMEW, TYLER SCOTT;TOOKES, HANSEL EMORY (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Academic Medical Centers;acceptability and feasibility;Address;Adherence;Adoption;Affect;AIDS prevention;Anti-Retroviral Agents;antiretroviral therapy;Award;Bacterial Infections;Blood;Buprenorphine;care outcomes;care systems;Caring;Clinic;Clinical effectiveness;Communities;Comprehensive Health Care;cost effective;cost effectiveness;Cost Effectiveness Analysis;COVID-19 pandemic;Data;Development;Diagnosis;Discrimination;Disease Outbreaks;Drug Screening;Drug usage;Drug user;Dryness;economic evaluation;Economics;Effectiveness;Effectiveness of Interventions;effectiveness-implementation RCT;effectiveness/implementation trial;efficacy evaluation;efficacy testing;Enrollment;Environment;Epidemic;Evaluation;evidence base;Evidence based intervention;experience;follow-up;Foundations;Future;Goals;Harm Reduction;Health;health care model;Healthcare Systems;Hepatitis C;Hepatitis C virus;HIV;HIV Infections;HIV risk;HIV/HCV;Human immunodeficiency virus test;Hybrids;implementation barriers;implementation evaluation;implementation process;implementation/effectiveness;Infection;Injecting drug user;injection drug use;innovation;Institution;Interdisciplinary Study;Intervention;Interview;medication for opioid use disorder;meetings;Methods;Modality;Modeling;models and simulation;naloxone dispensing;National Institute of Drug Abuse;Needle-Exchange Programs;novel;Opioid;opioid epidemic;Overdose;overdose education;Participant;patient navigation;peer;perceived discrimination;Persons;Pharmaceutical Preparations;pilot test;Policies;poor health outcome;Population;Positioning Attribute;Practical Robust Implementation and Sustainability Model;pre-exposure prophylaxis;prevent;prevention service;primary outcome;process evaluation;Randomized;Randomized, Controlled Trials;recruit;Research;response;scale up;screening;secondary outcome;service programs;Services;Sexually Transmitted Diseases;Site;social;social disparities;social stigma;Spottings;standard of care;Stimulant;substance use;Substance Use Disorder;Surveys;Syringes;telehealth;Tenofovir;Testing;Trust;uptake;Urine;Viral;Work

PROJECT_TITLE: In pursuit of a one-stop shop: a hybrid type 1 effectiveness-implementation trial of comprehensive tele-harm reduction for people who inject drugs


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: BLACKSBURG

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Project Narrative We will develop high-throughput and high-quality single-cell technologies based on droplet microfluidics for mapping genome-wide histone modifications and conducting multi-omic profiling that integrates epigenomic and transcriptomic analyses.

PI_NAMEs: LU, CHANG  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Address;Affect;anti-depressive agents;Biology;Brain;brain cell;cell type;Cells;Characteristics;Chemistry;ChIP-seq;Chromatin;chromatin immunoprecipitation;Complex;cost;Data;Data Set;design;Development;Disease;DNA Sequence;drug discovery;Encapsulated;Epigenetic Process;epigenome;epigenomic profiling;epigenomics;Exhibits;frontal lobe;Gene Expression;Gene Expression Regulation;Genes;Genome;Genome Mappings;genome-wide;genome-wide analysis;Genomics;Hallucinogens;Heterogeneity;histone modification;improved;Individual;Injections;insight;Life;Measurement;Microfluidic Microchips;microfluidic technology;Microfluidics;Molecular Biology;Molecular Conformation;Multiomic Data;multiple omics;Mus;Neurons;Neurosciences;next generation sequencing;Organ;Phenotype;Play;precision medicine;Process;Protocols documentation;response;Role;screening;single cell analysis;single cell technology;single-cell RNA sequencing;Technology;Tissue Sample;Tissues;tool;trait;transcriptome;transcriptome sequencing;transcriptomics;whole genome;Work

PROJECT_TITLE: Droplet microfluidic technology for single-cell epigenomic and multi-omic profiling

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dietary Supplements;Neurosciences;Nutrition;Obesity;Prevention;Sleep Research

PHR: PROJECT NARRATIVE Evidence is mounting that inappropriate timing of food intake contributes to obesity. The proposed research use gold-standard methods of characterizing circadian rhythm in humans to examine the metabolic impacts of food timing relative to endogenous circadian rhythm. Our study will lay the foundation for novel, circadian-based meal timing as a precision medicine approach to obesity and metabolic dysfunction.

PI_NAMEs: DUAN, DAISY  (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: actigraphy;Acute;Address;Adult;adult obesity;Affect;analytical method;Award;Behavior;Biological;blood glucose regulation;Blood specimen;Body Temperature;Body Weight decreased;Calories;Calorimetry;career;circadian;circadian biology;Circadian desynchrony;Circadian Rhythms;Clinical Trials Design;Consumption;Cross-Over Studies;design;dietary;Dietary Fats;Eating;Energy Metabolism;Enrollment;Exhibits;experience;experimental study;Fatty acid glycerol esters;feeding;Food;Foundations;Funding;Future;Glucose;Goals;Grant;hands-on learning;Health;healthy weight;Hour;Human;Human body;impaired glucose tolerance;in vivo;Indirect Calorimetry;Individual;Individual Differences;Inpatients;insight;Insulin;inter-individual variation;Intervention;K-Series Research Career Programs;Knowledge;Late Effects;Lead;Leadership;Light;light entrainment;Measures;Melatonin;men;Mentors;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolic dysfunction;Metabolic syndrome;Metabolism;Methods;Modernization;Morbidity - disease rate;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity development;obesity treatment;Oral;Oral Administration;Outcome;Output;oxidation;Palmitates;Participant;Persons;Phase;Phenotype;Population;precision medicine;Prediabetes syndrome;Predisposition;prevent;Prevention;programs;prospective;Protocols documentation;Publishing;Randomized;Research;Research Methodology;Research Personnel;Resources;response;Rest;Salivary;Signal Transduction;skills;Sleep;Societies;stable isotope;symposium;System;Techniques;Testing;Time;time interval;tool;Tracer;Training;United States National Institutes of Health;wearable device;Weight Gain;Woman;Writing

PROJECT_TITLE: Metabolic Effects of Circadian-Based Dinner Time

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK(M1)-1-B]