NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: ORONO

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF MAINE ORONO

ORG_STATE: ME

PHR: The project will address the means by which influenza virus is able to hijack the host cell to assemble new viruses from proteins and membranes produced by the cell. The project will specifically explore the interactions between host cell membrane components, the viral matrix protein M1, and certain conserved portions of the viral glycoprotein hemagglutinin, which is responsible for binding of the virus to the respiratory tract and entry into host cells, but whose frequent mutations have required vaccines to be continuously updated from season to season. Results will be used to accelerate the search for universal anti-viral therapies which are less susceptible to seasonal mutations of the virus.

PI_NAMEs: HESS, SAMUEL T (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acceleration;Actins;Acute;Acylation;Anti-viral Agents;Anti-viral Therapy;Binding;Binding Proteins;cell fixing;Cell membrane;Cells;Cellular Structures;Cysteine;Cytoplasmic Tail;Cytoskeleton;density;Drug Targeting;Electrostatics;Enzymes;Fluorescence;Fluorescence Resonance Energy Transfer;Fluorescence Spectroscopy;Glycoproteins;graduate student;Hemagglutinin;Image;improved;in vivo;Infection;Influenza;Influenza A virus;influenza virus strain;influenzavirus;inorganic phosphate;kinase inhibitor;knock-down;Label;Life Cycle Stages;Lipids;Location;Measures;Mediating;Membrane;Membrane Fusion;Membrane Glycoproteins;membrane model;Microscopy;molecular dynamics;Morbidity - disease rate;mortality;Motion;mutant;Mutate;Mutation;nanoscale;Outcome;particle;Pathway interactions;Persons;Pharmacotherapy;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Plasma Cells;Predisposition;Process;Property;protein transport;Proteins;Resistance;Respiratory System;Role;Seasons;Signal Pathway;Signal Transduction;single molecule;Spectrum Analysis;superresolution microscopy;Testing;Time;Transmembrane Domain;ultra high resolution;undergraduate student;Update;Vaccines;Viral;Viral Matrix Proteins;Viral Proteins;Virus;Virus Assembly;Virus Diseases

PROJECT_TITLE: The Role of Phosphoinositides in Influenza Virus Assembly

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Radiation Oncology;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH The challenges and benefits of high precision surgery are starkly apparent in the brain where maximal resection is the primary therapeutic approach, the primary indicator of overall survival, and where healthy tissue must be preserved. Advancements in diagnostic and imaging capabilities must be matched by surgical practices to be effective. Our proposal focuses on an order of magnitude improvement in surgical precision by resolving the persistent challenges of a) identifying tumor boundaries b) targeting them with ultrasound, and c) establishing interaction between imaging and therapy systems to avoid and/or target critical microvasculature.

PI_NAMEs: DAYTON, PAUL A;PINTON, GIANMARCO  (contact);SHAPIRO, MIKHAIL

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Acoustics;Address;Adjuvant;American;analog;Animals;Blood Vessels;Brain;Brain Neoplasms;brain tumor resection;cancer diagnosis;canine model;Canis familiaris;Cephalic;Collaborations;Complex;Consumption;contrast enhanced;Contrast Media;Convection;Custom;design;detection method;Diagnostic Imaging;diagnostic value;Diameter;Environment;Excision;Extravasation;Feedback;Focused Ultrasound;Focused Ultrasound Therapy;Frequencies;Gases;Glioblastoma;Glioma;Human;Image;image guided;imaging agent;imaging approach;imaging capabilities;imaging modality;improved;in vivo;Injectable;Injections;Intervention;Label;Laparoscopy;Magnetic Resonance Imaging;Malignant Neoplasms;meter;Methods;Microbubbles;minimally invasive;Monitor;mortality;Motion;nanoscale;Navigation System;neuroimaging;Neuronavigation;neurosurgery;Oncology;Operative Surgical Procedures;Outcome;Patients;Physiological;Pilot Projects;preservation;Prognosis;Prognostic Factor;Property;Public Health;quantitative imaging;Radiation therapy;Radiofrequency Interstitial Ablation;Radiosurgery;Resistance;Resolution;Robotics;Solid Neoplasm;Specificity;Structure;success;superresolution imaging;Surgeon;Survival Rate;System;targeted agent;Techniques;temozolomide;Therapeutic;Therapeutic Intervention;Three-Dimensional Imaging;Time;Tissues;tool;Translating;tumor;Tumor Volume;ultra high resolution;Ultrasonography;ultrasound;ultrasound ablation;Vesicle;Visualization

PROJECT_TITLE: Ultra-high precision image-guided incisionless transcranial ultrasound surgery

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Nutrition

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: The Integrated Physiology of Aging Core (IPA) has been a part of the NSC for about 29 years to a) provide services to local, na�onal, and interna�onal inves�gators to characterize the physiological changes in animal models (mice, rats, naked mole-rats, and non-human primates) of aging, and b) examine the eﬀects of various interven�ons (dietary, gene�c, and pharmacological) on age-related physiological changes, including metabolism and behavior. The services of the IPA Core are available to and have been used by inves�gators from the other cores of the San Antonio NSC, the Interven�on Tes�ng Program, San Antonio, Pepper Center, other departments at UT Health, and at other academic ins�tu�ons in the United States. The IPA Core provides inves�gators with services in aging animal models (mice, rats, naked mole-rats, and non- human primates) and makes the resul�ng data widely available to the scien�ﬁc community Project Narra�ve

PI_NAMEs: HORNSBY, PETER J;SALMON, ADAM ;STRONG, RANDY  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: age related;age related changes;age-related disease;Aging;aging mechanism;aging process;aging related;Animal Model;Animals;Behavior;Biological Assay;Biology of Aging;Capsicum;Carbon Dioxide;Communities;Data;Data Analyses;design;dietary;Discipline;Eating;Energy Metabolism;Equipment;Funding;Genes;Health;healthspan;improved;interest;Knowledge;Measures;Metabolic;Metabolism;Mission;Mole Rats;Monitor;Mus;nonhuman primate;normal aging;old mice;Organ;Performance;pharmacologic;Physiological;Physiology;programs;Rattus;Research;Resource Sharing;response;Rodent;Services;Shock;System;United States;water testing

PROJECT_TITLE: San Antonio Nathan Shock Center of Excellence in the Biology of Aging


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Over 1 million older adults with Alzheimer's Disease and Related Dementias (ADRD) live alone in the US, and little is known about their use of medications, support for medication management, or how to intervene effectively to optimize their use of medications. The objectives of this Beeson K76 proposal are to characterize medication use and medication management supports among older people with ADRD who live alone, to understand in-depth multifaceted perspectives on their use of medications, and to develop a stakeholder- informed clinical decision framework to support clinicians and guide future interventions to optimize medication use in this group. Ultimately, the information learned from this proposal will lead to the development of clinical interventions to improve quality of life and reduce medication-related harms for older adults with ADRD who live alone.

PI_NAMEs: GROWDON, MATTHEW EVAN (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adherence;Adverse drug event;Adverse event;Aging;Alzheimer's disease related dementia;Award;California;career;career development;Caring;Cessation of life;Clinical;clinical decision-making;clinical development;Complex;Conflict (Psychology);Data;Dementia;dementia care;drug misuse;Epidemiology;evidence based guidelines;experience;Exposure to;Face;falls;Feeling;Focus Groups;Funding;Future;Goals;Grant;Health;Health Services;high risk;Home;Hospitalization;Impaired cognition;improved;innovation;insight;Insulin;Intervention;Interview;Knowledge;Leadership;Learning;Literature;Lived experience;Measures;Medicare claim;medication compliance;Medication Management;Mentors;multidisciplinary;older adult;Older Population;Outcome;Participant;Patient-Focused Outcomes;Pattern;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;preference;prototype;Qualitative Research;Quality of life;Recommendation;Regimen;Research;Research Methodology;Research Personnel;Risk;Risk Factors;San Francisco;skills;social vulnerability;Source;Stress;Surveys;Testing;Therapeutic;therapy design;therapy development;Training;trend;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Optimizing medication use and support among people with dementia who live alone

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-6 (M1)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Estrogen;Eye Disease and Disorders of Vision;Genetics;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

ORG_STATE: MA

PHR: Project Narrative Fuchs Endothelial Corneal Dystrophy (FECD) is the major cause of progressive blindness from corneal endothelial cell death and the second most common cause of corneal transplants performed on the elderly (>65 years old) in the U.S.; moreover, women comprise almost 75% of patients undergoing corneal transplantation for FECD. In FECD, corneal endothelium, a layer of cells whose primary function is to maintain corneal transparency, is hypothesized to have heightened susceptibility to ultraviolet light and smoking that activate abnormal estrogen and melatonin metabolism and cause mitochondrial damage, leading to formation of abnormal cellular deposits and progressive cell death, intensified with aging. Understanding key regulators of these pathogenic mechanisms may facilitate development of pharmacologic treatment for FECD patients.

PI_NAMEs: JURKUNAS, ULA V. (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acute;Affect;Age;age related;Aging;Antioxidants;Apoptosis;aqueous;Aqueous Humor;Aryl Hydrocarbon Receptor;Ataxia;ataxia telangiectasia mutated protein;Attenuated;Bioenergetics;Biogenesis;Blindness;Cell Cycle;Cell Cycle Arrest;Cell Death;Cell Line;Cells;Cornea;Corneal edema;Corneal Endothelium;CYP1B1 gene;cytochrome c;Data;Degradation Pathway;Deposition;Development;Disease;DNA;DNA Damage;DNA Repair;DNA Repair Disorder;Elderly;Endothelial Cells;Endothelium;environmental stressor;Enzymes;Estrogen Metabolism;Estrogens;Etiology;Extracellular Matrix;Family;Female;Fibrosis;Fuchs' Endothelial Dystrophy;Genetic;genotoxicity;Genotype;Goals;Grant;Human;human old age (65+);in vivo;inhibitor;Injury;Intervention;Keratoplasty;Knockout Mice;Laboratories;Lead;Light;Link;Liquid substance;M cell;M Phase Arrest;male;Mediating;Melatonin;Mesenchymal;Metabolism;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mouse model;Mus;Mutate;non-genetic;NQO1 gene;Oxidants;oxidation;oxidative damage;oxidative DNA damage;Oxidative Stress;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pharmacological Treatment;Phenotype;Polyploid Cells;Polyploidy;Predisposition;Proteins;Receptor Activation;repaired;response;restoration;Role;senescence;Serotonin;sex;Smoke;Smoker;Smoking;Specimen;Stress;System;Telangiectasis;Tissues;transcriptome sequencing;ultraviolet;Ultraviolet Rays;UVA induced;Woman;women versus men;Women's prevalence

PROJECT_TITLE: Role of Oxidative Stress in Pathogenesis of Fuchs Endothelial Corneal Dystrophy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Major Depressive Disorder;Mental Health;Mental Illness;Precision Medicine;Serious Mental Illness

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Depression in older adults is often treatment resistant, despite many effective treatment options. In the Biotype-assigned Augmentation Approach in Resistant Late-Life Depression (BAARD) project, we will develop and test a treatment selection tool informed by an individual’s depression characteristics to improve outcomes.

PI_NAMEs: BUTTERS, MERYL A;FELSKY, DANIEL ;LENZE, ERIC J;NICOL, GINGER E (contact);VOINESKOS, ARISTOTLE NICHOLAS

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Adult;Age;age group;aged;aging biomarker;aging brain;aging related;allostatic load;anti-depressive agents;aripiprazole;Behavior;biobank;Biologic Characteristic;Biological;Biological Markers;biotypes;Blood;Bupropion;Cell Aging;Characteristics;Chronic;Clinical;clinical care;clinical decision support;clinical decision-making;clinical implementation;Clinical Treatment;Clinical Trials;Clinical Trials Network;Cognition;Cognitive;Cognitive deficits;cognitive function;comorbidity;comparison group;Conduct Clinical Trials;Data;Data Set;Death Rate;Depressed mood;design;Diagnosis;Disease remission;disorder subtype;early life adversity;effective therapy;effectiveness/implementation trial;Elderly;Focus Groups;frailty;Functional disorder;Future;Genetic;genetic variant;geriatric depression;Geroscience;Health Care Costs;high dimensionality;implementation barriers;improved;improved outcome;Incidence;Individual;Inflammation;Interview;Lead;machine learning prediction;Major Depressive Disorder;Measures;Mental Depression;Methods;Modeling;molecular marker;molecular subtypes;Mood Disorders;mortality;Multi-Institutional Clinical Trial;Multicenter Trials;multidisciplinary;multiple omics;neuroimaging;neuroinflammation;neurovascular;older adult;Participant;participant enrollment;Pathway interactions;Patients;Pharmacotherapy;Phase;Population;precision medicine;Prediction of Response to Therapy;prospective;Proteomics;prototype;Psychiatry;Psychopharmacology;Qualitative Research;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Research;Research Methodology;Resistance;response;Selection for Treatments;Site;skills;Specific qualifier value;suicidal morbidity;support tools;Testing;tool;Treatment outcome;treatment-resistant depression;Trees;Validation

PROJECT_TITLE: Biotype-assigned Augmentation Approach in Resistant late life Depression (BAARD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (05)]


NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: PROJECT NARRATIVE Diabetic retinopathy, a prevalent microvascular complication, is the leading cause of vision loss worldwide. This project seeks to understand the mechanisms through which endothelial cells control interactions with leukocytes, and, thereby, the outcomes of diabetic retinopathy. This information is critical to improve therapeutic strategies for retinal diseases and to prevent blindness.

PI_NAMEs: CHRZANOWSKA, MAGDALENA  (contact);GRANT, MARIA BARTOLOMEO

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Adhesions;angiogenesis;Blindness;Blood Vessels;cadherin 5;Caveolae;caveolin 1;Cell Adhesion;cell behavior;Cell membrane;Cell Physiology;Cholesterol;Data;Development;Diabetes Mellitus;Diabetic Retinopathy;Disease;Early Intervention;Endothelial Cells;endothelial dysfunction;Endothelium;Ephrin-B2;Equilibrium;Event;Exhibits;Generations;genetic approach;Genetic Transcription;Glucose;Goals;Grant;Homeostasis;Human;Hyperactivity;Hyperglycemia;improved;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Ischemia;KDR gene;Knock-out;Leukocytes;Leukostasis;Mediating;Membrane;Membrane Microdomains;Methods;Microscopy;Microvascular Dysfunction;migration;Modeling;Modernization;Molecular;Monomeric GTP-Binding Proteins;Mus;mutant;neovascularization;Neuropilins;Nitric Oxide;Outcome;Oxidation-Reduction;Pathogenesis;Pathologic;Pathologic Neovascularization;Pathology;Permeability;Phenotype;Physiological;Play;Positioning Attribute;prevent;Publishing;receptor;Research;response;Retina;Retinal Diseases;retinal ischemia;Retinopathy of Prematurity;Role;Signal Transduction;Signaling Molecule;Stimulus;Streptozocin;Structure;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapy outcome;TNF gene;TNFRSF1A gene;transcriptomics;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factor Receptor-3;Vascular Endothelial Growth Factors

PROJECT_TITLE: Endothelial Rap1 restricts inflammation in the retina


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: IMPRINT is a one-year immersive learning experience for graduate students and postdocs. The program will enable student par@cipants to translate their knowledge to real-world solu@ons for preven@ng and/or trea@ng Alzheimer’s Disease & Demen@a Related diseases (ADRD) through educa@onal programming that combines immersion in the lived experiences of people aﬀected by Alzheimer’s, with training in key aspects of entrepreneurship. Par@cipants will work in teams to propose and assess poten@al technologies for commercializa@on.

PI_NAMEs: GANNON, GAIL CHRISTINE;JENKINS, SUSAN  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Active Learning;Acute;Address;Adult;Affect;aged;Aging;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease related dementia;Biology;brain health;Brain imaging;Brain Pathology;caregiving;Caring;clinical development;cohort;Collaborations;Color;Communities;Data Science;design;Development;Diagnosis;digital phenotyping;Discipline;Disease;Early Diagnosis;Ecosystem;Elements;empowerment;Entrepreneurship;Environment;Ethics;Ethnography;Evidence based intervention;experience;Familiarity;Fostering;Foundations;Functional disorder;graduate student;Grant;Health;Health Sciences;Health Technology;Healthcare;Healthcare Systems;Hybrids;ideation;Immersion;Individual;Industry;Infrastructure;innovation;insight;interdisciplinary approach;interest;Knowledge;Laboratory Finding;Learning;Legal;Life Style;Lived experience;Marketing;memory care;Methods;Modeling;Neurosciences;novel;Outcome;Participant;Patients;pedagogical content;Persons;Policies;Postdoctoral Fellow;prevent;Prevention;programs;project-based learning;prototype;Remote session;Research;research clinical testing;San Francisco;Services;Silver;Site Visit;skills;Small Business Innovation Research Grant;Small Business Technology Transfer Research;social;social cognitive theory;Societies;Students;Techniques;Technology;tool;Training;Translating;Tsunami;United States;Work;Writing

PROJECT_TITLE: IMPRINT - Immersive Methods for Promoting Research and Innovations through Novel Training - for Alzheimer's Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-I (M2)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Neurosciences;Pain Research;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This proposal lays out a new approach to use optical technology to provide novel imaging and physiologic measures relevant to the pelvic floor muscle as a method to quantify and spatially distinguish the muscular dysfunction underlying female myofascial pelvic pain. Once validated, this approach may serve as an effective, non-invasive, and scalable method to assess pelvic floor muscle fitness and allow for the prospective study of changes in pelvic floor fitness following myofascially-directed therapies. The development of machine learning models will also attempt to predict individual responses to different treatments for myofascial pelvic pain using the spatial NIRS assessment of the pelvic floor, both improving the clinical care of the condition and providing novel insight into the disease pathophysiology.

PI_NAMEs: ACKERMAN, A. LENORE  (contact)

PROGRAM_OFFICER_NAME: TUTTLE, ALEXANDER H

PROJECT_TERMS: 3-Dimensional;Acidosis;Address;Adult women;Affect;Aftercare;Biological Markers;Bladder;Bladder Dysfunction;Caring;Categories;chronic pelvic pain;Clinical;clinical care;comparison control;Data;design;Development;Devices;Diagnosis;Disease;effective therapy;Epidemic;Evaluation;Female;fitness;Functional disorder;Goals;Gynecology;Helping to End Addiction Long-term;hemodynamics;Image;Imaging Techniques;Impairment;improved;Individual;individual response;Inflammatory;inflammatory marker;Injections;innovation;insight;Integrative Medicine;interdisciplinary collaboration;Intervention;Intestines;Machine Learning;machine learning model;Measurement;Measures;Mediator;Medicine;men;Methods;Muscle;Muscle relaxation phase;Musculoskeletal;Nature;Near-Infrared Spectroscopy;neuroinflammation;novel;novel imaging technique;novel strategies;novel therapeutics;Optics;Outcome;Outcomes Research;Pain management;pain patient;pain perception;Pathology;Patients;Pattern;Pelvic Floor Muscle;Pelvic floor structure;Pelvic Pain;pharmacologic;Phase;Physical therapy;Physiological;Physiology;predicting response;prediction algorithm;Prediction of Response to Therapy;prevent;prospective;Prospective Studies;quantitative imaging;Recovery;Regimen;Research;Resolution;response;Role;Serum;Severities;Sexual Dysfunction;Specialist;spectroscopic imaging;statistical and machine learning;symptomatic improvement;symptomatology;Syndrome;systemic inflammatory response;Technology;technology validation;Therapeutic;Time;Tissues;Toxin;Training;treatment response;United States National Institutes of Health;Urology;Vagina;Woman

PROJECT_TITLE: Quantitative Assessment of Pelvic Floor Muscle Fitness in Myofascial Pelvic Pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 SH (14)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Patient Safety;Rare Diseases;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SCOTTSDALE

ORG_NAME: VITALANT

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Cerebral amyloid angiopathy is a disease which affects the small blood vessels in the brain and common cause of spontaneous brain bleeds. Previous research has shown that it is caused by unnatural clumping of the protein amyloid β and that it can be transmitted between animals in experiments, and possibly also between humans. In this research study we will investigate if amyloid β can also be transmitted between humans through blood transfusion.

PI_NAMEs: BUSCH, MICHAEL PAUL (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: abeta accumulation;Affect;Allogenic;Alzheimer's Disease;Amyloid beta-Protein;Animals;beta amyloid pathology;Biochemical;Blood donor;Blood Transfusion;Blood Vessels;Brain;Cadaver;Case Fatality Rates;Cerebral Amyloid Angiopathy;Cerebral hemisphere hemorrhage;Cerebrovascular system;Clinical;clinical database;Cohort Studies;Data;Databases;Denmark;Deposition;Detection;Development;Disease;Erythrocytes;Evaluation;Exhibits;experimental study;follow-up;Goals;Health;Hemorrhage;Human;Iatrogenesis;Longterm Follow-up;Measures;National Heart, Lung, and Blood Institute;neurosurgery;Outcome;Patients;Prevalence;prion-like;Prions;Property;Proteins;Publications;Reporting;repository;Research;research study;Retrospective cohort study;Risk;Risk Assessment;Route;Sampling;Scandinavian;Somatropin;Sweden;tau-1;Transfusion;Translational Research;transmission process;Vascular blood supply;Veins

PROJECT_TITLE: Possible transfusion transmitted cerebral amyloid angiopathy: evaluation of transmission of Aβ using the RADAR repository

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-K (M1)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE  Carotid artery stenosis is a leading cause of stroke, accounting for 10-15% of ischemic strokes across the United States. This proposal will utilize computational fluid dynamics (CFD) informed by magnetic resonance imaging (MRI) data to identify changes in hemodynamic parameters after carotid endarterectomy as well as plaque features that may predict higher stroke risk. A better understanding of altered hemodynamics in cerebrovascular disease, including before and after carotid artery revascularization will allow for better patient selection for operative intervention in patients with asymptomatic carotid artery stenosis.

PI_NAMEs: BRAET, DREW JACKSON (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Accounting;Anatomy;Angiography;Arterial Fatty Streak;arterial spin labeling;biomarker identification;Biomechanics;Calibration;Carotid Arteries;Carotid Artery Plaques;Carotid Endarterectomy;Carotid Stenosis;Cephalic;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrum;Cessation of life;Clinical;cohort;Compensation;Computer Analysis;Data;Diagnosis;Diagnostic Imaging;efficacy evaluation;hemodynamics;high risk;indexing;Internal Carotid Artery Stenosis;Intervention;Ischemic Stroke;Lesion;Liquid substance;Long term disability;Magnetic Resonance Imaging;Methods;Modeling;Morphology;Operative Surgical Procedures;Patient imaging;Patient Selection;patient subsets;Patients;Perfusion;Postoperative Period;pressure;Protocols documentation;Qualifying;repaired;revascularization;Severities;shear stress;Stenosis;Stress;Stroke;stroke patient;stroke risk;Testing;ultrasound;United States;Work

PROJECT_TITLE: A Magnetic Resonance Imaging Based Computational Analysis of Plaque Morphology and Hemodynamics in Patients with High Grade Asymptomatic Carotid Artery Stenosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-B(20)L]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PUBLIC HEALTH RELEVANCE Pancreatic cancer is the 4th leading cause of cancer related deaths and has a dismal 5-year survival rate of 10%. Lethality is attributed to early metastasis, late detection, and resistance to currently available therapies. This study seeks to understand mechanisms of therapeutic resistance, immune dysfunction, and metastasis in order to identify new rational therapies for pancreatic cancer patients.

PI_NAMEs: SCHMIECHEN, ZOE  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Ablation;Adoptive Transfer;Antigens;Automobile Driving;Biological Response Modifiers;cancer cell;Cancer cell line;Cancer Etiology;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Line;Cell Separation;Cells;Cessation of life;Characteristics;Combined Modality Therapy;CRISPR/Cas technology;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;DDR2 gene;Detection;Development;discoidin domain receptor 2;Disease;Disseminated Malignant Neoplasm;Doctor of Philosophy;effective therapy;exhaust;exhaustion;Flow Cytometry;FOXP3 gene;Functional disorder;Gene Expression Profile;Genes;Genetic Models;Goals;Grant;Histologic;Human;immune checkpoint blockade;Immune Evasion;Immune response;Immune System Diseases;Immunocompetent;Immunologic Surveillance;Immunotherapy;Implant;implantation;Infiltration;Intrinsic factor;Invaded;Investigation;Knock-out;Knowledge;Link;Malignant neoplasm of pancreas;Malignant Neoplasms;Microscopy;Modeling;Mus;neoantigens;Neoplasm Metastasis;Newly Diagnosed;novel;Organ;overexpression;Pancreas;pancreatic cancer patients;Pancreatic Diseases;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patients;Phenotype;Population;prevent;public health relevance;Receptor Protein-Tyrosine Kinases;Regimen;Regulatory T-Lymphocyte;Research;Research Personnel;Resistance;retroviral transduction;Role;Signal Transduction;single-cell RNA sequencing;standard of care;Survival Rate;T cell differentiation;T-Cell Activation;T-Cell Depletion;T-Lymphocyte;T-Lymphocyte Subsets;Technical Expertise;Testing;therapeutic development;therapeutic target;therapy resistant;transcriptome sequencing;tumor;Tumor Antigens;Tumor Burden;Tumor Cell Line;tumor growth;tumor microenvironment;tumor progression;tumor-immune system interactions;Variant

PROJECT_TITLE: Elucidating the Role of Tregs in Cancer Metastasis and T Cell Dysfunction


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Data Science;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Microbiome;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: COVID-19 is characterized by heterogenous symptoms and outcomes, and identifying what factors determine disease severity is a top priority. The airway microbiome has emerged as a differentiating factor, with a less diverse, dysbiotic microbiome found early in more severe disease. This work aims to carry these associations to the species level, understand how comorbidities influence the microbiome, and leverage advanced machine learning to start identifying potential microbe-host interaction mechanisms.

PI_NAMEs: MERENSTEIN, CARTER  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 2019-nCoV;Acceleration;ACE2;Actinomyces;Address;Affect;Age;Animal Model;Antibiotics;Bacteria;cell type;Cessation of life;Clinical;clinical phenotype;cohort;comorbidity;COVID-19;COVID-19 impact;COVID-19 patient;COVID-19 risk;COVID-19 severity;cytokine;cytokine release syndrome;Data;Databases;Development;Diabetes Mellitus;Disease;Disease Outcome;dysbiosis;Enrollment;Etiology;Experimental Animal Model;Experimental Designs;experimental study;follow-up;Future;Gene Expression;Genes;Graph;Hand;Hemophilus;Heterogeneity;high risk;Hospitalization;host microbiome;host-associated microbial communities;host-microbe interactions;human old age (65+);Immune;Immune response;immunoregulation;In Vitro;Individual;Infection;Interferon Type II;knowledge graph;Life;Link;Literature;Lung Diseases;Lung infections;Machine Learning;Manuals;Mediating;metagenomic sequencing;Methods;Microbe;microbiome;microbiome alteration;microbiome composition;microbiome research;morphogens;multiple data types;Neisseria;Obesity;oral commensal;Oropharyngeal;Outcome;pathogen;Pathway interactions;Patients;Phenotype;Prevotella;protein protein interaction;public database;Publishing;Respiratory Disease;Respiratory Failure;respiratory microbiome;Respiratory System;Respiratory Tract Infections;Risk;Risk Factors;Sampling;SARS coronavirus;SARS-CoV-2 infection;severe COVID-19;Severities;Severity of illness;Shapes;Specificity;Specimen;Stratification;superinfection;supplemental oxygen;Symptoms;synergism;Taxonomy;Techniques;tool;transcriptome sequencing;Uncertainty;Upper respiratory tract;Validation;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: The Respiratory Microbiome in COVID-19: Associations with Severity, Risk Factors, and Host Pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Electronic Nicotine Delivery Systems;Lung;Natural Products;Prevention;Tobacco

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Vaping products containing Δ8-tetrahydrocannabinol (Δ8-THC), an unregulated psychoactive compound, are increasingly popular across the United States; however, little is known about their respiratory health effects. Evaluation of Δ8-THC vaping products is a public health imperative because vaping-induced thermal oxidation converts Δ8-THC into electrophilic quinones which may cause lung injury. Studies outlined in this proposal will determine the biological effects of Δ8-THC aerosol exposure on human lung cells, components of commercial products driving Δ8-THC oxidation to reactive quinones, and proteins covalently modified by these quinones.

PI_NAMEs: LOVE, CHARLOTTE ANN (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Address;adduct;aerosolized;Aerosols;Affect;Air;airway epithelium;Antioxidants;Automobile Driving;Biological;Blood Pressure;Breathing;bronchial epithelium;Cannabidiol;Cannabinoids;Cell Physiology;Cells;Cessation of life;Chemicals;Chemistry;cilium motility;Communication;Communities;Cysteine;cytotoxicity;Decision Making;Development;Disease Outbreaks;Dose;Educational Curriculum;Electronic cigarette;electronic cigarette use;Epithelial Cells;Evaluation;Event;Exposure to;Farm;Flavoring;Future;Gene Modified;Goals;Health;Heart Rate;Heavy Metals;high school;Human;Impairment;In Vitro;Individual;Inflammatory Response;Inhalation Exposure;innovation;Internet;Isomerism;Juice;junior high school;Knowledge;Legal;Liquid substance;Lung;lung health;lung injury;Manufacturer;Marijuana;marijuana use;marijuana user;Marketing;Mediating;metal chelator;Metals;Methodology;Nobel Prize;novel;novel strategies;Oils;oxidation;Oxidative Stress;Pathway interactions;Patients;Pesticides;Physical condensation;Prevention;Process;Proteins;Proteomics;Psychotropic Drugs;Public Health;public health relevance;Quinones;Reactive Oxygen Species;Reporting;Research;Research Personnel;respiratory;respiratory health;Risk;Safety;safety assessment;Science;Scientist;Shotguns;statistics;Sulfhydryl Compounds;Surveys;Symptoms;System;Technical Expertise;Techniques;Tetrahydrocannabinol;THC concentration;THC exposure;Time;Toxic effect;Toxicology;Training;training opportunity;transcriptome sequencing;Translating;Unconscious State;United States;vaping;vaping associated lung injury;vaping THC;vaporization;Vomiting;Work;wound healing

PROJECT_TITLE: Respiratory health effects of aerosolized delta-8-THC and its oxidation products


NIH_SPENDING_CATS: Contraception/Reproduction;Lymphatic Research;Women's Health Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The proposed research project aims to characterize the development and functions of the murine uterine lymphatics: we hypothesize that the uterine lymphatics develop postnatally under molecular patterning guidance from uterine blood vessels and functionally, they maintain fluid homeostasis within the uterine environment throughout estrous phases and pregnancy and are essential for successful embryonic implantation and gestation. This study has the potential to not only address the dearth of academic knowledge on uterine lymphatics but also provide novel understanding of the basis of uterine fertility and disease from the lymphatic perspective.

PI_NAMEs: ZHAO, LUPING  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: absorption;Address;Adult;Amniotic Fluid;Back;Blood Circulation;Blood Vessels;Cells;Clinical;Conflict (Psychology);Consensus;Data;Development;Dietary Fats;Digestion;Disease;Drainage procedure;Dryness;Embryo;endometriosis;Endometrium;Environment;Estrous Cycle;Estrus;Fertility;fetal;Fluid Balance;Genes;Genetic;genetic approach;Goals;Growth;Health;Image;Immune;Immune response;implantation;in vivo;Inflammatory Response;Injections;Ink;insight;Intercellular Fluid;interstitial;Knock-out;Knowledge;Label;Ligation;Lipids;Liquid substance;loss of function;Lymph;Lymphatic;lymphatic development;Lymphatic Diseases;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic System;lymphatic vessel;lymphoid organ;Maintenance;Maternal-Fetal Exchange;Measures;Molecular;Morphology;mouse model;Mus;mutant mouse model;Myometrial;natural Blastocyst Implantation;Neoplasm Metastasis;novel;Operative Surgical Procedures;Organ;Outcome;Outcome Study;Pathogenesis;Pattern;Phase;Play;postnatal;postnatal development;Pregnancy;Published Comment;Regulation;Reporter;Reporting;Reproductive Health;Research Project Grants;Role;Site;Speed;Techniques;theories;Time;timeline;Tissues;Tracer;trafficking;uptake;Uterine Diseases;Uterus;Vascular Endothelial Growth Factor C;Visualization;Weight;Work

PROJECT_TITLE: Study of the Development and Function of the Uterine Lymphatics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-L(20)L]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Natural Products

ORG_CITY: HAVERFORD

ORG_DEPT: CHEMISTRY

ORG_NAME: HAVERFORD COLLEGE

PHR: Microorganisms use protein assemblies to produce diverse molecules that serve humanity as antibiotics, anticancer agents, and antivirals. This study aims to uncover how these assemblies select their small molecule inputs that are then transformed by the team of proteins into the programmed structurally complex output. Information from these studies will be used to strategically engineer these protein assemblies to incorporate desired molecular inputs, which in turn will unlock sustainable routes to new medicinally important molecules.

PI_NAMEs: CHARKOUDIAN, LOUISE KARINE (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acyl Carrier Protein;Acylation;Acyltransferase;Address;Amino Acid Sequence;Anabolism;Anti-viral Agents;Antibiotics;Antineoplastic Agents;Award;Binding Proteins;Binding Sites;Biology;Bypass;Chemistry;Chimeric Proteins;Coenzymes;college;Complex;Data;design;Development;Engineering;Environment;Enzymes;experience;Failure;flexibility;Foundations;Funding;Future;Gatekeeping;Goals;holo-(acyl-carrier-protein) synthase;Humanities;innovation;insight;Knowledge;Literature;Location;manufacture;Medicine;melting;Methods;microorganism;Modification;Molecular;Molecular Conformation;Motion;mutant;natural product hybrids;Natural Products;next generation;novel;Outcome;Output;Pathway interactions;Peptides;peptidomimetics;Play;polyketide synthase;polyketides;Positioning Attribute;Process;Property;Protein Conformation;Protein Engineering;protein protein interaction;protein structure;Proteins;Publishing;Research;Research Personnel;Research Project Grants;Rest;Role;Route;Site;small molecule;Spectrum Analysis;Structure;success;System;Temperature;Training;Transferase;undergraduate research experience;undergraduate student;Work

PROJECT_TITLE: Functional Hybrid Natural Product Synthases by Tracking Acyl Carrier Protein Binding and Conformational Dynamics

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: ALBANY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

ORG_STATE: NY

PHR: Project Narrative Heart failure is a syndrome of major public health significance. In the United States alone, the prevalence of heart failure is estimated at 6.5 million individuals and this number is increasing steadily by about one million per year. A better understanding of the cellular mechanisms that control pathological cardiac hypertrophy, should lead to novel strategies for therapeutic intervention in heart failure.

PI_NAMEs: BOIVIN, BENOIT  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Affect;Binding;Cardiac Myocytes;cardioprotection;Cells;Complex;Data;Dependovirus;Development;Ectopic Expression;Event;experimental study;Functional disorder;functional restoration;Gene Expression;gene repression;Growth;Heart;Heart failure;Heart Hypertrophy;hormonal signals;Hormone Responsive;Hypertrophy;improved;in vivo;Individual;insight;knock-down;Knockout Mice;Knowledge;Left Ventricular Function;Left Ventricular Hypertrophy;Mediating;Mediator;Molecular;Mus;Muscle Cells;Myocardial;Nature;non-genomic;novel;novel therapeutic intervention;Nuclear;Oxidants;oxidation;Oxidative Stress;Pathologic;Pathway interactions;Patients;Peptides;pharmacologic;Phenotype;Phosphorylation;Phosphotyrosine;PIK3CG gene;Play;Post-Transcriptional Regulation;posttranscriptional;pressure;Prevalence;prevent;Protein Dephosphorylation;protein tyrosine phosphatase 1B;Proteins;Proto-Oncogene Proteins c-akt;Public Health;Publishing;Reactive Oxygen Species;Regulation;Repression;Research;Response Elements;Role;Series;Severities;Signal Transduction;Source;Syndrome;Testing;Therapeutic;Therapeutic Intervention;Thyroid Hormone Receptor;Thyroid Hormones;tool;Transcriptional Regulation;Translating;translation factor;treatment guidelines;Triiodothyronine;Tyrosine;United States;Work

PROJECT_TITLE: Role of Protein Tyrosine Phosphatase 1B in Cardiac Hypertrophy

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Rural Health

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Mindfulness meditation delivered by smartphone app has the potential to improve psychological wellbeing and decrease psychological distress at scale among young people placed in the legal system. Our team recently conducted a successful single-site feasibility trial of a mindfulness meditation app designed with and for youth on probation in Chicago Cook County, but now faces key barriers to running a fully-powered trial that can produce effectiveness and implementation data generalizable beyond a single site. The proposed multi-site feasibility trial will systematically expand our protocol into rural and urban counties in Oregon and New York, evaluating key feasibility benchmarks and setting the stage for a fully-powered hybrid type 2 effectiveness-implementation trial with youth placed on probation across the West Coast, Midwest, and East Coast.

PI_NAMEs: KENDALL, ASHLEY D. (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Achievement;Address;Adherence;Anxiety;Benchmarking;Chicago;Clinical Trials;Collaborations;cooking;County;Data;design;Development;Distress;Ecological momentary assessment;Educational process of instructing;Effectiveness;effectiveness/implementation trial;emotion dysregulation;Enrollment;evidence base;Face;feasibility testing;feasibility trial;Focus Groups;Funding;Future;Gender;Health;health disparity;Heterogeneity;Hybrids;Illinois;Impairment;implementation intervention;implementation outcomes;improved;Individual;interest;Intervention;Interview;juvenile justice system;Leadership;Legal;Legal Intervention;Legal system;Life;Meditation;Mental Depression;Mental Health;Methods;mHealth;Midwestern United States;mindfulness meditation;minority communities;New York;Oregon;Outcome;peer;Personal Satisfaction;Persons;physical conditioning;Play;Population;Positioning Attribute;probation;Procedures;programs;Protocols documentation;psychological distress;Quality of life;Randomized;recidivism;recruit;Reporting;resilience;response;Role;Running;Rural;Rural Community;Sampling;satisfaction;Site;smartphone application;Structure;success;System;Technology;Testing;Text Messaging;Time;tool;United States National Institutes of Health;Urban Community;Vocation;Well in self;whole health;Youth

PROJECT_TITLE: Improving Psychological Wellbeing and Decreasing Psychological Distress among Youth in the Legal System: Multi-Site Feasibility Trial of a Mindfulness Meditation App

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 BH (02)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emergency Care;Heart Disease;Lung;Patient Safety;Pediatric;Prevention

ORG_CITY: Columbus

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE  Resuscitation from critical illness requires skillful delivery of oxygen. This project will compare three paramedic strategies for delivering life-saving oxygen to critically-ill children. The findings will improve public health by defining approaches to improve survival and reduce years of life loss among critically-ill children.

PI_NAMEs: WANG, HENRY E. (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Accounting;Address;Adverse event;Age;Agreement;Applied Research;Bayesian Analysis;Benefits and Risks;Brain;Caring;Categories;Child;Child Care;Child Health;Child health care;Childhood;Clinical;clinical care;Clinical Trials Network;Communities;community consultation;compare effectiveness;Complement;Complex;Consensus;Critical Care;Critical Illness;Critically ill children;Databases;Dedications;design;Devices;Disease;Dose;Emergency Care;Emergency research;Ensure;Event;evidence base;experience;Gel;Guidelines;Heart;Heart Arrest;Hospitals;improved;Informed Consent;innovation;Institutional Review Boards;International;Interview;Intratracheal Intubation;Knowledge;Laryngeal Masks;Larynx;Life;Lung;Manuals;Masks;multidisciplinary;novel;operation;out-of-hospital cardiac arrest;Outcome;Oxygen;Paramedical Personnel;Patients;pediatric emergency;Pediatric Hospitals;Phase;Physician Executives;Pre-hospitalization care;prevent;Protocols documentation;Public Health;Recommendation;relative effectiveness;Resources;Respiratory Failure;Resuscitation;Safety;Secure;Seizures;skills;Survival Rate;synergism;Techniques;Testing;Training;Trauma;Traumatic injury;trial design;trial enrollment;Tube;United States Agency for Healthcare Research and Quality;United States Health Resources and Services Administration;Variant;ventilation;years of life lost

PROJECT_TITLE: 1/2 – Pediatric Prehospital Airway Resuscitation Trial

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Lung;Organ Transplantation;Orphan Drug;Pulmonary Hypertension;Rare Diseases;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The innovative design of this catheter when coupled with a compatible pulmonary support system would provide patients with severe pulmonary arterial hypertension and right ventricular failure a therapy that can significantly improve the survival and provide time for medical therapies to be initiated and take effect. This will also allow the patient to be supported while they are waiting on the transplant list. In the long-term and future progress, this cannula and eventual system design will allow for ambulation and portability so the patient would not need to reside on bedrest in a hospital while waiting for a donor organ and provide a better chance to rehabilitate.

PI_NAMEs: BENZA, RAYMOND LOUIS (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute;Address;Animals;Aorta;Bed rest;Biomechanics;Blood;Blood flow;Brain;Cannulas;Cardiac;Cardiac Output;Cardiopulmonary;care costs;Catheters;Cessation of life;Chronic;Chronic Disease;Clinic;Clinical;cohort;computer design;Computer Simulation;Coupled;Custom;Data;design;Development;Devices;Disease;Docking;effective therapy;Engineering;Event;Extracorporeal Membrane Oxygenation;fabrication;Functional disorder;Future;Gases;Generations;Genetic Complementation Test;Goals;Heart;Heart Atrium;Heart failure;hemodynamics;Hospitals;Hour;Hypoxemia;improved;In Vitro;in vivo evaluation;Inequity;innovation;instrument;Internal jugular vein structure;Left;Left atrial structure;Left ventricular structure;Lower Extremity;Lung;Lung Transplantation;Marketing;Mechanics;Medical;Monitor;Morphology;mortality;novel;novel therapeutics;operation;Operative Surgical Procedures;Organ;Organ Donor;Oxygenators;patient response;Patients;Perfusion;pharmacologic;portability;Positioning Attribute;pressure;pressure sensor;prevent;Process;prototype;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary artery structure;Pulmonary Edema;Pulmonary Hypertension;pulmonary vascular remodeling;Pulmonary vessels;Pump;Recovery;Refractory;Resources;Right atrial structure;right ventricular failure;Right ventricular structure;Risk;Series;Sheep;sheep model;Shunt Device;Side;Specific qualifier value;success;Support System;Surgeon;System;Testing;therapy design;Time;time use;Training;Transplantation;Treatment Efficacy;Validation;vascular injury;Venous;Vision;Waiting Lists

PROJECT_TITLE: The Development of a Biatrial Catheter for a Cardiopulmonary Support System in Pulmonary Arterial Hypertension


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Mental Health;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: Aurora

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Mild cognitive impairment is common in older adults and can affect a person’s ability to understand, reason and appreciate the consequences of a decision. The goal of this proposal is to adapt, refine and test a deep brain stimulation surgery decision aid that addresses cognitive weaknesses and improves decisional outcomes for people with Parkinson’s disease. Our decision support tool will serve as a model for improving decision- making and care for older adults with neurologic disease and cognitive impairment.

PI_NAMEs: FULLARD, MICHELLE ERIN (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Alzheimer's Disease;Benefits and Risks;career;Caring;Clinical Trials Design;Cognitive;cognitive impairment in Parkinson's;Complex;Conflict (Psychology);Consent;Data;Decision Aid;Decision Making;decision-making capacity;Deep Brain Stimulation;design;Diagnosis;Educational workshop;Effectiveness;effectiveness testing;Evaluation;Executive Dysfunction;executive function;Exhibits;expectation;experience;Exposure to;Feedback;Future;Goals;Health Care Costs;health care service;Healthcare;Impaired cognition;implementation evaluation;implementation science;improved;insight;International;Intervention;Intervention Studies;Interview;K-Series Research Career Programs;Knowledge;Measures;Medical;meetings;Memory;Mentors;Mentorship;Methods;mild cognitive impairment;Modeling;Nervous System Disorder;Neuropsychology;older adult;Operative Surgical Procedures;Outcome;Parkinson Disease;Patients;Persons;pilot trial;Population;Pragmatic clinical trial;pragmatic trial;Process;processing speed;prototype;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Regrets;Reporting;Research;Research Personnel;Resources;retention rate;satisfaction;Scientist;shared decision making;Structure;support tools;Surveys;Testing;therapy design;Time;tool;Training;treatment as usual;trial design;verbal;Work

PROJECT_TITLE: Improving Shared Decision-Making for Older Adults with Cognitive Impairment: Parkinson's Disease as a Model


NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Pediatric;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE Thousands of common genetic variants have now been robustly associated with neurodevelopmental and psychiatric disorders, including autism spectrum disorder (ASD) and schizophrenia, yet translating these genetic findings into a concrete understanding of the biological mechanisms underlying these disorders remains a major obstacle hindering clinical translation. To interpret these findings, substantial efforts have been undertaken to generate tissue- and cell-type-specific population-level functional genomic atlases linking genetic variants with nearby alterations in gene expression, splicing, and isoform changes. Here, we seek to develop new methods and resources to systematically characterize the regulation of alternative polyadenylation (APA) -- an understudied yet critical cellular mechanism for gene regulation and trafficking -- during human brain development and its contribution to neurodevelopmental and psychiatric disorders.

PI_NAMEs: GANDAL, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: 3' Untranslated Regions;3-Dimensional;Address;Adult;Affect;Area;Atlases;autism spectrum disorder;Autopsy;Binding Sites;Biological;Biological Assay;Brain;brain tissue;candidate identification;Cell Differentiation process;Cell Nucleus;cell type;Cells;clinical translation;cohort;Communities;Data;deep learning;deep learning model;deep sequencing;density;Development;developmental genetics;Disease;disorder risk;DNA Sequence;Event;Exhibits;Functional disorder;functional genomics;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Research;genetic variant;genome annotation;genome editing;Genome engineering;genome wide association study;genome-wide;genomic locus;Genomics;Heritability;high throughput screening;Human;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;insight;Knock-out;Length;Link;loss of function;Maps;Mediating;Mental disorders;Messenger RNA;Metabolism;Methods;MicroRNAs;Molecular;mRNA Stability;Neocortex;Nerve Degeneration;nerve stem cell;network models;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neuron development;Neuronal Differentiation;Neurons;neurophysiology;neuropsychiatric disorder;neuropsychiatry;Neurosciences Research;novel;Pathway interactions;Patients;Pattern;Phenotype;Polyadenylation;Population;postnatal;posttranscriptional;predictive modeling;Protein Isoforms;Quantitative Trait Loci;Regional Disease;Regulation;Regulatory Element;Resolution;Resources;Risk;risk variant;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Schizophrenia;screening;Second Pregnancy Trimester;sex;Signal Transduction;single nucleus RNA-sequencing;Site;Specificity;stem cell model;success;Synapses;targeted treatment;Testing;therapeutic development;Therapeutic Intervention;Tissue Sample;Tissues;trafficking;Training;Transcript;transcriptome sequencing;Translating;Translations;Untranslated Regions;Variant;Work

PROJECT_TITLE: Cellular and developmental genetic regulation of 3' isoform diversity in the human brain and its contribution to neuropsychiatric disorders

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Orphan Drug;Rare Diseases;Sickle Cell Disease

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Sickle Cell Disease (SCD) is a common genetic disorder that affects approximately 100,000 people of African heritage in the US, and more than 4 million worldwide. This project will use a novel method to identify compounds that prevent red blood cell sickling. Our overall goal is to identify new anti-sickling agents suitable for advancement as experimental treatments for SCD.

PI_NAMEs: ARCHER, DAVID R (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Address;Advanced Development;Affect;Affinity;African;Algorithms;Amino Acid Substitution;analog;animal efficacy;animal safety;Antisickling Agents;beta Globin;Biological Assay;Blood;Blood capillaries;Bone Marrow Transplantation;Cell membrane;Cellular Morphology;Cessation of life;Chemicals;Chronic;Clinical;Clinical Research;cost;Cytolysis;cytotoxicity test;detection assay;Development;Disease;Dissociation;Dose;drug candidate;Drug Interactions;Effectiveness;efficacy evaluation;efficacy study;Erythrocytes;Evaluation;Exhibits;FDA approved;Fetal Hemoglobin;Future;Gene Modified;gene therapy;Genes;Genetic Diseases;Globin;Goals;Half-Life;Hemoglobin;Hemoglobin concentration result;hemoglobin polymer;Hemolysis;Hereditary Disease;high throughput screening;high-throughput drug screening;Human;human subject;Hypoxia;Image;improved;improved outcome;in silico;in vivo;Individual;innovation;Investigational Therapies;Kidney Failure;Laboratories;Lead;Libraries;Life Expectancy;Medical;medication safety;Membrane;meter;Methods;Microscopy;miniaturize;Modeling;Monitor;Morphology;mouse model;Mus;novel;novel therapeutics;Osmosis;Oxygen;Pathogenicity;Pathway interactions;Patients;Peripheral;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Phenotype;Physiological;pre-clinical;preclinical study;Preclinical Testing;premature;prevent;Property;Red Blood Cell Count;response;Reticulocyte count;safety assessment;safety study;scaffold;screening;Series;Shapes;Sickle Cell;Sickle Cell Anemia;sickling;side effect;small molecule;small molecule therapeutics;Stroke;Structure-Activity Relationship;targeted agent;Technology;Testing;Therapeutic;Tissues;tool;Transfusion;Treatment outcome;vaso-occlusive crisis

PROJECT_TITLE: Small Molecule Therapeutics for Sickle Cell Anemia


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Assistive Technology;Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CLEVELAND

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Narrative We will develop a new intravascular ultrasound system which has several distinct advantages as compared to current systems. This new system will enable cardiologists to better understand, diagnose, and treat coronary artery disease.

PI_NAMEs: FLEISCHMAN, AARON J (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Address;Algorithms;Animals;Area;Arterial Fatty Streak;Biological Markers;Blood Vessels;Cadaver;Cardiovascular system;Carotid Arteries;Carotid Artery Plaques;Catheters;Classification;Clinical;Clinical Research;commercialization;Computer software;Coronary;Coronary Arteriosclerosis;coronary event;cost;Custom;Decision Making;deep learning;design;Devices;Diagnosis;Disadvantaged;Dissection;Ensure;Evaluation;Event;Flushing;Focused Ultrasound;Frequencies;Friends;Future;Geometry;harmonic distortion;Histology;Image;image visualization;imaging biomarker;imaging modality;imaging system;improved;innovation;integrated circuit;interest;Intervention;Kidney Diseases;Length;Machine Learning;machine learning algorithm;machine learning method;Magnetic Resonance Imaging;manufacture;Measurement;Measures;Methods;microelectronics;Morphology;Noise;novel;Optical Coherence Tomography;Oryctolagus cuniculus;Output;Patients;Penetration;Performance;Pharmacotherapy;Physicians;Polychlorinated Biphenyls;Polymers;Predictive Factor;Prevalence;printed circuit board;Procedures;Production;Reader;Research;Research Personnel;Resolution;Risk Factors;Role;Rotation;Signal Transduction;software development;Stents;Structure;success;System;Technology;Testing;Thick;Thinness;Thrombosis;Tissues;tool;Transducers;treatment planning;Tumor Debulking;Ultrasonic Transducer;Ultrasonics;Ultrasonography;ultrasound;virtual;Visualization;volcano;Work

PROJECT_TITLE: Broad Bandwidth Transducers for High Resolution Information Rich IVUS


NIH_SPENDING_CATS: Biotechnology;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Idiopathic pulmonary fibrosis (IPF) remains a debilitating and ultimately fatal lung disease; current therapies marginally slow progression and have very limited improvements in overall survival. The YAP/TAZ transcription factors have been shown to play a central role in fibroblast activation and matrix deposition, but they also play essential roles in other lung-resident cell types. We have devised a cell-type selective approach that has allowed us to identify novel molecules that inhibit the fibrotic activity of YAP/TAZ in fibroblasts, and our proposed work will further optimize toward a lead compound that can be developed in to an effective therapy for IPF.

PI_NAMEs: HAAK, ANDREW JON;HEYNEN-GENEL, SUSANNE  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Accounting;Actins;Agonist;analog;Biological Assay;Cardiovascular system;Cell Maintenance;Cell Nucleus;Cell Physiology;cell type;Cells;Cessation of life;Chronic;cofactor;Complex;Coupled;Cytoplasm;Deposition;Development;differential expression;Disease;Disease Progression;Diversity Library;Dopamine Agonists;Dopamine D1 Receptor;Dopamine Receptor;DRD1 gene;drug discovery;Drug Targeting;effective therapy;Endothelial Cells;Endothelium;Epithelial Cells;Epithelium;Europe;experimental study;Extracellular Matrix;Fibroblasts;Fibrosis;Funding;G-Protein-Coupled Receptors;Genes;Genetic Transcription;Goals;Grant;GTP-Binding Protein alpha Subunits, Gs;Hepatic;high throughput screening;Homeostasis;Human;idiopathic pulmonary fibrosis;improved;In Vitro;in vitro activity;in vivo;in vivo Model;Individual;inhibitor;Internet;Kidney;LATS1 gene;Lead;Lung;Lung Diseases;Mechanical Stress;Mediating;Metabolic Pathway;Modeling;Molecular;mortality;mouse model;Muscle;novel;novel therapeutics;Nuclear;Pathway interactions;Patients;Peptide Hydrolases;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Phenotype;Phosphorylation;Play;Prevalence;programs;Proliferating;Property;Proteins;Pulmonary Fibrosis;pulmonary function decline;Rodent Model;Role;Route;scaffold;scale up;screening;Series;side effect;Signal Transduction;Skin;small molecule;small molecule inhibitor;stem cells;Structure-Activity Relationship;Testing;Therapeutic;Therapeutic Agents;therapeutic development;therapeutic target;therapeutically effective;therapy outcome;Tissues;transcription factor;Transcriptional Coactivator with PDZ-Binding Motif;treatment strategy;United States;Work

PROJECT_TITLE: Optimization of fibroblast-selective inhibitors of YAP/TAZ as novel therapeutics for Pulmonary Fibrosis


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases;Lung;Nanotechnology

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE Bedside chest x-ray radiograph (CXR) is the most often requested imaging examination for the commonly encountered pulmonary diseases in the intensive care units (ICU) and is also routinely used for the assessment of various catheters and tubes. However, the diagnostic values of CXR are low and are severely limited by structural/anatomical overlaps and are further compromised by superposition of devices, tubes and catheters that are common for ICU patients. The aim of this proposal is to develop the world’s first mobile 3D digital tomosynthesis scanner to provide better diagnosis at the patient’s bedside in ICU.

PI_NAMEs: ZHOU, OTTO Z (contact)

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;Anatomy;Area;Breast;Breast Cancer Detection;Calibration;Carbon Nanotubes;Catheters;Characteristics;Chest;Clinical;Collaborations;cost comparison;COVID-19 pandemic;COVID-19 patient;COVID-19 pneumonia;Critical Illness;Dental;design;detector;Devices;Diagnosis;diagnosis standard;Diagnostic;diagnostic accuracy;Diagnostic Imaging;diagnostic value;digital;Digital Radiography;Dose;Engineering;experience;experimental study;Exposure to;follow-up;Geometry;Goals;Image;imaging capabilities;imaging modality;imaging study;imaging system;improved;innovation;Intensive Care;Intensive Care Units;invention;Laboratory Research;Legal patent;Lung Diseases;Marketing;Measures;Mechanics;Medical;Medical Device;Methods;Notification;novel;Orthopedics;Patient imaging;Patients;Performance;Phase;Physicians;point of care;portability;Procedures;Process;Production;Productivity;prototype;Pulmonary Heart Disease;Radiation;Radiation exposure;radiologist;Radiology Specialty;reconstruction;Reproducibility;Roentgen Rays;safety testing;Scientist;simulation;software development;Source;System;Systems Integration;Technology;Testing;Thoracic Radiography;Three-Dimensional Imaging;tomography;tomosynthesis;Translating;Translational Research;Tube;Validation;Visualization;Voice;Work;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: Bedside 3D diagnostic imaging in ICU


NIH_SPENDING_CATS: Asthma;Lung

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE One of the key features of asthma is exaggerated airway narrowing by hypercontractile airway smooth muscle. Our group has shown that smooth muscle cells transmit force to the surrounding airway via tethering proteins such as integrin α2β1. This research proposal aims to design, screen, and validate novel small molecule inhibitors of integrin α2β1 with the goal of improving therapeutic options for the treatment of asthma.

PI_NAMEs: JO, HYUNIL ;SUNDARAM, APARNA BALA (contact)

PROJECT_TERMS: Actins;Acute;Adhesions;Adrenal Cortex Hormones;Adrenergic beta-Agonists;airway hyperresponsiveness;allergic airway disease;analog;Animal Model;Anti-Inflammatory Agents;Antibodies;Asthma;asthma model;Award;Biological Assay;Biological Availability;Biology;Bronchodilator Agents;Calcium;California;candidate validation;Cells;Characteristics;chronic respiratory disease;Collaborations;Collagen;Cryoelectron Microscopy;cytokine;Data;design;Development;Diagnosis;disease model;Drug Design;Drug Kinetics;efficacy validation;experience;Extracellular Matrix;Generations;Goals;Half-Life;Homeostasis;human tissue;IgE;Impairment;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;Inhalation;inhibitor;Integrin alpha2beta1;Integrins;Interleukin-13;Lead;lead optimization;lead series;Leukotrienes;Ligand Binding;Ligation;Mediating;Mediator;Medical;Medicine;meter;methacholine;Modification;Mus;Muscle;Muscle Contraction;Myosin ATPase;Myosin Light Chain Kinase;Nature;novel;novel strategies;Oral;Parents;Pathway interactions;Patients;Permeability;persistent symptom;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacology;Phase;Plasma;Play;Preclinical Drug Development;Prodrugs;professor;protective effect;Proteins;Publishing;Relaxation;Research Proposals;respiratory smooth muscle;Role;San Francisco;scale up;Scientist;screening;Seasons;Signal Transduction;small molecule inhibitor;Smooth Muscle;Smooth Muscle Myocytes;Solubility;Stimulus;Structure;targeted treatment;Testing;Therapeutic;therapeutic candidate;Therapeutic Uses;tool;Toxic effect;Toxicology;transmission process;Universities;Validation;Work

PROJECT_TITLE: Mitigation of Exaggerated Smooth Muscle Force with Inhibitors of Integrin Alpha2Beta1


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative (Public Health Relevance) Alzheimer's Disease (AD) is an age-related neurodegenerative condition characterized by the impairment of microglia, the cells responsible for clearing protein aggregates. This proposal aims to uncover novel microglial regulators that are disrupted in AD: the F99 phase will investigate the role of the RNA binding protein, Quaking, in AD progression, while the K00 phase will shed light on the significance of the lipid, PI3P, in microglial membrane dynamics. These findings have the potential to advance the treatment of AD by identifying novel therapeutic targets and shedding light on the molecular mechanism influencing microglial function in AD.

PI_NAMEs: MCKENZIE, TAKESE TASSEEN (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: abeta deposition;age related;age related neurodegeneration;aged;Aging;aging related disease;Agonist;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease risk;American;Amyloid beta-Protein;Attenuated;Automobile Driving;Autopsy;Biology;Brain;brain cell;Cause of Death;Cells;Central Nervous System;Characteristics;Cognitive deficits;Data;Demyelinations;density;Development;disability;Disease;Disease Progression;Down-Regulation;Elderly;Endosomes;Enzymes;experimental study;familial Alzheimer disease;field study;Foundations;Functional disorder;Genes;Genetic;Histopathology;Homeostasis;Human;Impaired cognition;Impairment;Inflammatory;Knowledge;Laboratory Research;Light;Link;lipidomics;Lipids;Measures;Membrane;Membrane Lipids;Mentors;Mentorship;Metabolism;Microglia;Molecular;Motor;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;Neurons;new therapeutic target;novel;pathogen;Pathogenesis;Pathology;Phagocyte Bactericidal Dysfunction;Phagocytes;Phagocytosis;Phagosomes;pharmacologic;Phase;phosphatidylinositol 3-phosphate;PIK3CG gene;Play;Population;Postdoctoral Fellow;PPAR-beta;Prevalence;prevent;Process;protein aggregation;public health relevance;Publishing;Quantitative Reverse Transcriptase PCR;Regulation;Research;Research Personnel;Research Project Grants;Risk Factors;RNA-Binding Proteins;Role;Senile Plaques;single-cell RNA sequencing;skills;Study models;Testing;Training;transcription factor;transcriptome;transcriptomics;Transgenic Mice;United States;Work

PROJECT_TITLE: Elucidating Novel Regulators of Microglial Phagocytosis in Alzheimer’s Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-J (M1)]


NIH_SPENDING_CATS: Aging;Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Neurodegenerative;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: SEATTLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Millions of adults above 65 years of age report communication challenges, including age-related declines in speech motor control and motor speech problems caused by neurodegenerative conditions such as Parkinson’s disease. Given that efforts to develop effective treatments are hindered by a lack of data on how aging affects speech motor learning and control, this project investigates in patients with deep brain stimulation implants and in typically aging individuals which neural circuits and sensorimotor processes involved in speech production are affected by the aging process. The findings will inform effective motor learning-based behavioral and neuromodulation approaches to prevent and ameliorate aging-related speech motor difficulties.

PI_NAMEs: WANG, HANTAO  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Adult;Affect;Age;age effect;age related;age related decline;age related neurodegeneration;Age Reporting;Age Years;Aging;aging brain;aging process;aging related;Auditory;Awareness;base;Base Sequence;Behavior;Behavioral;Brain;California;career;Cell Nucleus;Clinical;Communication;Communication difficulty;Computer Models;Data;Deep Brain Stimulation;Development;Devices;effective therapy;Elderly;Electroencephalography;Essential Tremor;Feedback;Frequencies;Ganglia;Goals;healthy aging;Impaired cognition;Impairment;Implant;Implanted Electrodes;Individual;insight;Knowledge;Learning;Limb structure;Magnetic Resonance Imaging;Magnetoencephalography;Mentors;Modeling;Motor;motor control;motor impairment;motor learning;multimodal neuroimaging;Nerve Degeneration;neural;neural circuit;neural network;neuroimaging;Neurologic;neuromechanism;Neurons;neuroregulation;Neurosciences;older adult;Parkinson Disease;Participant;patient subsets;Patients;Phase;Population;Postdoctoral Fellow;pre-doctoral;preservation;prevent;Process;Production;Productivity;Quality of life;Research;sensorimotor system;sequence learning;Series;skills;Social isolation;Speech;Speech Disorders;Structure of subthalamic nucleus;support network;Techniques;Therapeutic;Time;Training Programs;treatment program;Universities;Ventral Lateral Thalamic Nucleus;Washington;Work;young adult

PROJECT_TITLE: Aging-related Changes in the Neural Mechanisms Underlying Speech Motor Learning


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The proposed research aims to advance our understanding of how the brain prioritizes information from cluttered visual environments to guide ongoing behavior. This process, broadly referred to as selective attention, is impaired in several clinical populations, including individuals with spatial neglect after stroke, attention deficit hyperactivity disorder (ADHD), schizophrenia, and autism spectrum disorders (ASD). By better understanding the separable neural processes that contribute to selective attention, we hope to generate more pointed hypotheses about its dysfunction, leading to more effective treatments and interventions.

PI_NAMEs: KASTNER, SABINE  (contact);KNIGHT, ROBERT THOMAS

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Afferent Neurons;Animal Model;Attention;Attention deficit hyperactivity disorder;attentional control;autism spectrum disorder;Behavior;behavior prediction;Behavioral;behavioral outcome;Brain;cell type;Clinical;Clutterings;Cognition;Cognitive;Cues;Detection;effective intervention;effective therapy;electrical microstimulation;Electroencephalography;Electrophysiology (science);Environment;extrastriate;Feedback;flexibility;Frequencies;frontal eye fields;Functional disorder;gaze;Glues;Health;Human;Impairment;Individual;innovation;lateral intraparietal area;Lesion;Link;Location;Macaca;Mediating;microstimulation;Modeling;Monkeys;Motor;Motor Neurons;neural;neurodevelopment;neuromechanism;Neurons;neuropsychiatric disorder;novel;Pathway interactions;Pattern;Perception;Periodicity;Phase;Play;Population;Population Dynamics;post stroke;Primates;Process;Property;Pulvinar structure;Reaction Time;Research;Role;Saccades;Sampling;Schizophrenia;segregation;selective attention;Sensory;sensory system;Shapes;spatial neglect;Stimulus;System;Testing;Thalamic structure;theories;Theta Rhythm;Time;Visual;Visual attention;Visual Fields;visual information;visual processing

PROJECT_TITLE: Neural basis of visual attention in the primate brain

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Kidney Disease;Pediatric;Precision Medicine;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: LAY NARRATIVE  MCD, FSGS, MN, and IgAN are rare glomerular diseases of the kidney that cause serious illness including kidney failure and high mortality, generating enormous individual and societal burden. CureGN has assembled nephrologists, researchers with expertise in different scientific disciplines, and patients in a consortium that maintains and analyzes a large, longitudinal observational database and biosamples like blood, urine, and images of kidney biopsies. This initiative has developed a critical infrastructure that will advance our ability to study, classify, characterize, diagnose, and treat primary glomerular diseases of the kidney.

PI_NAMEs: GREENBAUM, LAURENCE A;KLEIN, JON ;SMOYER, WILLIAM E (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Acceleration;Achievement;actionable mutation;Address;Adult;Advocacy;Affect;Ancillary Study;APOL1 gene;biobank;Biology;biopharmaceutical industry;Biopsy;Blood;career development;Child;Childhood;Classification;Clinic;Clinical;clinical center;Clinical Data;Clinical Research;cohort;Collaborations;Collection;Communication;Communities;community engagement;Consultations;Data;Data Collection;data collection methodology;Data Coordinating Center;Databases;Development;Diagnosis;digital pathology;Discipline;Disease;Disease remission;Educational workshop;Electronic Health Record;Emerging Technologies;Enrollment;Ensure;Epigenetic Process;Etiology;Focal and Segmental Glomerulosclerosis;follow-up;Formalin;Fostering;Funding;Funding Agency;Future;Genetic;genome sequencing;Goals;Grant;Health Technology;Heterogeneity;high risk;high standard;IGA Glomerulonephritis;Immunologics;improved;Individual;Industry;industry partner;Infrastructure;innovation;International;Investigation;kidney biopsy;Kidney Diseases;Kidney Failure;kidney imaging;Knowledge;Longitudinal, observational study;Medical Record Linkage;Membranous Glomerulonephritis;metabolomics;Methods;mHealth;Michigan;Mission;mobile application;Modernization;Morbidity - disease rate;mortality;multidisciplinary;multimodal data;Natural History;Nephrology;next generation;North Carolina;novel;observational cohort study;Observational Study;Outcome;Output;outreach;pandemic disease;Paraffin Embedding;Participant;participant retention;Pathogenesis;Pathology;patient advocacy group;Patient Care;patient engagement;Patient Outcomes Assessments;Patient Participation;Patients;Pattern;Pennsylvania;personalized care;Persons;Phase;Pilot Projects;Population;precision medicine;predict clinical outcome;Procedures;Process;Productivity;Professional Organizations;Prognosis;programs;prospective;Protocols documentation;Publications;Publishing;recruit;Renal glomerular disease;repository;Research;Research Personnel;risk variant;Role;sample collection;Sample Size;Science;Scientist;Services;Site;social;social health determinants;Standardization;Statistical Data Interpretation;Structure;Time;Tissue Embedding;tool;Training;transcriptome sequencing;Translational Research;treatment response;treatment strategy;Universities;Urine;Visit;whole genome;Work;working group

PROJECT_TITLE: CUREGN 3.0 - Pediatric Nephrology Consortium - PCC

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-6 (M1)]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Mental Health;Pediatric;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative The proposed research is relevant to public health because it will advance a program of research evaluating the potential for a mindfulness-based intervention to prevent escalations in adolescent conduct problems such as aggression, defiance, violence, and criminality. These behaviors represent a major public health concern with substantial costs to individuals, their families, and larger society.

PI_NAMEs: PIEHLER, TIMOTHY F (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: active control;Address;Adolescent;Aggressive behavior;anti social;Area;arm;Attention;Awareness;Behavior;behavioral health intervention;Benchmarking;Breathing;conduct problem;cost;Data;Data Collection;design;Development;Education;Effectiveness;efficacy evaluation;efficacy trial;Emotional;Emotions;Enrollment;evidence base;Exhibits;Failure;Family;feasibility research;Feedback;Focus Groups;Future;future implementation;Goals;High Prevalence;Home;implementation intervention;improved;Individual;innovation;Intervention;intervention delivery;Interview;Investigation;Learning;Life;Methods;mindfulness;mindfulness intervention;mobile application;mobile computing;Motivation;Neurocognitive Deficit;novel strategies;Participant;participant retention;Penetration;Persons;Phase;Preparation;prevent;Prevention;preventive intervention;Procedures;programs;Protocols documentation;Public Health;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Resources;response;Risk;Risk Behaviors;Risk Factors;Sampling;Schools;Self-control as a personality trait;skills;social;Societies;Stress;success;synergism;Target Populations;Techniques;Testing;Training;usability;Violence;Youth

PROJECT_TITLE: A Pilot Investigation of a Mobile Application-Enhanced Mindfulness-Based Preventive Intervention Targeting Adolescent Conduct Problems


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE The proposed work will demonstrate a new three dimensional (3D) printing technique for generation of vascular channels in hydrogel matrices via the use of air as a new ink and explore the use of such a technique for fabrication of vascularized tissues. Successful completion of the proposed work will have a great potential to pioneer the development of a disruptive 3D printing technology and advance its utilization in fabrication of vascularized scalable tissues.

PI_NAMEs: OZBOLAT, IBRAHIM  (contact);RAVNIC, DINO J

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: 3-Dimensional;3D Print;Adhesions;Air;angiogenesis;Atherosclerosis;Biocompatible Materials;Biological Process;Biomechanics;bioprinting;Blood Vessels;bone;Bone Regeneration;Bone Tissue;Calvaria;cell motility;Cell Physiology;Cell-Cell Adhesion Inhibition;Cells;Collaborations;Coupled;Coupling;craniofacial;crosslink;Data;Defect;Deposition;Development;Device or Instrument Development;Devices;Diameter;disease model;drug testing;Elasticity;Endothelial Cells;Excision;experience;fabrication;Gel;Generations;Goals;Growth;Hindlimb;Hydrogels;In Vitro;in vitro Model;in vivo;Ink;instrument;Knowledge;Liquid substance;Literature;meter;Micropuncture;Microsurgery;Modeling;new technology;Operative Surgical Procedures;Organ;organ on a chip;osteogenic;Performance;Phase;photopolymerization;Printing;Process;Property;Rattus;Regenerative Medicine;regenerative tissue;Reporting;Residual state;Rest;scaffold;Silicones;simulation;Solid;Speed;Stress;Techniques;Technology;technology platform;Thinness;Time;Tissue constructs;Tissue Engineering;Tissue Model;Tissue Transplantation;Tissues;tool;vascular tissue engineering;Vascularization;viscoelasticity;Viscosity;Work

PROJECT_TITLE: 3D Printing of Air: An Intangible Ink for Fabrication of Vascularized Tissues

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Precision Medicine;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PI_NAMEs: CLARK, CHERYL RENEE;KARLSON, ELIZABETH W;MURPHY, SHAWN N;O'CONNOR, GEORGE T;SMOLLER, JORDAN W (contact)

PROGRAM_OFFICER_NAME: MCNEIL FORD, NICOLE

PROJECT_TERMS: Address;Adult;Advisory Committees;Age;All of Us Research Program;Area;Awareness;Back;Biomedical Research;Boston;Caring;Childhood;Clinic;clinical care;Clinical Research;clinical research site;cohort;Collaborations;Collection;Communication;Communities;community engagement;community organizations;community partners;Consent;cooking;cost effectiveness;County;COVID-19;Data;Data Collection;data exchange;data resource;design;Education;Educational process of instructing;Employee;Enrollment;Ensure;Equity;ethnic diversity;ethnic minority;Ethnic Origin;Evaluation;Event;experience;extrinsic motivation;Feedback;flexibility;Food;Foundations;Geographic Locations;Geography;Goals;Health;Health system;Hospitals;Human Resources;improved;Income;Individual;Integrated Health Care Systems;interest;intrinsic motivation;Leadership;Learning;life span;Longitudinal cohort study;Low income;Lupus;Maine;Massachusetts;Measurement;Medical center;Mental Health;Methods;minority communities;Modification;Monitor;New England;New Hampshire;Newsletter;nutrition;operation;outreach;Participant;participant enrollment;participant retention;Patients;performance site;Population;precision medicine;Primary Care;Primary Prevention;Procedures;Process;Productivity;Program Development;programs;Race;racial minority;recruit;Research;Research Personnel;retention rate;Rhode Island;Role;Rural;Rural Population;safety net;sample collection;Science;Services;Site;Standardization;Structure;success;Surveys;Teenagers;Training;United States;Universities;Vaccination;virtual;Work

PROJECT_TITLE: All of Us New England Remote Enrollment and Engagement, Nutrition for Precision Health Support


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Brain Disorders;Cardiovascular;Cerebrovascular;Diabetes;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Prevention;Stroke

ORG_CITY: SAINT LOUIS

ORG_NAME: SENSEION THERAPEUTICS, INC.

PHR: Project Narrative Type 2 diabetes (T2D) and cardiovascular disease (CVD) are major overlapping health concerns in today’s society. Therefore, developing novel drugs that treat both type 2 diabetes and thrombosis is a therapeutic priority. The proposed research is relevant to the mission of the NCATS because it proposes to develop LRRC8 complex modulators (SN-4XX) for to treat both T2D and thrombotic diseases to reduce stroke myocardial infarction in T2D patients. Exploring this therapeutic approach and testing a series of LRRC8 modulators will expand our understanding of novel therapeutic avenues and delineate an innovative target for the treatment and prevention of diabetes and cardiovascular disease.

PI_NAMEs: CHO, JAEHYUNG ;LERNER, DANIEL J (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: absorption;Agonist;Antiplatelet Drugs;Aspirin;atherosclerotic plaque rupture;Biological Availability;blood glucose regulation;Blood Platelets;Blood Vessels;Caco-2 Cells;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;care costs;Cause of Death;Cells;Cerebrum;Cessation of life;Clinical;Clinical Research;Combined Modality Therapy;Complex;Coronary;Cyclic GMP;cytotoxicity;Data;Diabetes prevention;Diabetic mouse;Direct Costs;Dose;Drug Kinetics;Economic Burden;efficacy study;Ensure;Event;Excretory function;Experimental Genetics;GCG gene;glycemic control;Head;Health;Hemorrhage;Hospitalization;Human;Human Genetics;Human Genome;improved;In Vitro;in vivo;inhibitor;innovation;Integrins;Investigational Drugs;Investigational New Drug Application;Ion Channel;Ischemia;Isoenzymes;Lead;lead series;Leucine-Rich Repeat;manufacture;manufacturing organization;Marketing;Metabolism;meter;Mission;mouse genetics;multiple drug use;Mus;Myocardial Infarction;Myocardial Ischemia;National Center for Advancing Translational Sciences;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Oral;pandemic disease;Patients;Permeability;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phase 1 study;phase 2 study;phenome;platelet function;pre-clinical;prevent;Proteins;receptor;Regulation;Research;Residual state;response;Series;Signal Transduction;Site;small molecule;Societies;Solubility;Stroke;Stroke prevention;stroke therapy;Testing;Therapeutic;Thrombin Receptor;Thrombosis;thrombotic;Thrombus;tool;Toxic effect;Work

PROJECT_TITLE: Targeting LRRC8 signaling to prevent & treat arterial thrombosis in type 2 diabetes


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Immunization;Immunotherapy;Nanotechnology;Neurodegenerative;Neurosciences;Prevention;Vaccine Related

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are devastating disorders, and therapies that slow or stop disease progression are urgently needed. Vaccines that generate anti-Aβ and anti-tau antibodies are a promising strategy, however vaccine design is stalled because of problematic inflammatory responses, which AD patients are already highly susceptible to. We will develop a new peptide nanofiber platform as a safe and effective vaccine strategy for inducing non-inflammatory protection against AD/FTD.

PI_NAMEs: JACKREL, MEREDITH E.;RUDRA, JAI  (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;AD transgenic mice;Adjuvant;Affect;age effect;aging population;Alzheimer Vaccines;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;amyloid formation;Anti-Inflammatory Agents;Antibodies;Antibody Affinity;Antibody Response;Antibody Therapy;Antibody titer measurement;Antigen Presentation;Antigens;Autoantigens;Autophagocytosis;Binding;Biochemical;Biodistribution;Biological Assay;Biophysics;Biosensor;Brain;Cells;Clinical Data;Clinical Research;Clinical Trials;cognitive function;combat;Communicable Diseases;comparison control;conformer;Conjugated Carrier;cost;cytokine;cytotoxicity;Data;Dementia;Dendritic Cells;design;Development;Disease;disease model;Disease Progression;Dose;efficacy evaluation;efficacy testing;Electrons;Encephalomyelitis;Enzyme-Linked Immunosorbent Assay;Epitopes;Equilibrium;Exhibits;experimental study;Foundations;Frontotemporal Dementia;Hand;Human;Immune response;Immune signaling;Immune Tolerance;Immunization;Immunize;immunogenicity;Impaired cognition;Impairment;improved;in vivo;in vivo imaging system;Individual;Inflammaging;Inflammation;Inflammatory;Inflammatory Response;Investigation;Link;Mammalian Cell;Measures;Molecular;monomer;Morphology;mouse model;Mus;nanofiber;nanomaterials;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;Neurons;neuropathology;old mice;older adult;Onset of illness;Outcome;palliative;passive antibodies;Pathologic;Pathology;Patients;Pattern;Peptides;Pharmaceutical Preparations;Phenotype;Preclinical Testing;Predisposition;prevent;Preventative vaccination;Preventive vaccine;Process;Production;Property;protein aggregation;Proteins;Public Health;response;Safety;Scheme;self assembly;self organization;Senile Plaques;Series;side effect;Sterility;success;Surface;Surface Plasmon Resonance;Symptoms;synthetic peptide;System;systemic toxicity;tau Proteins;Testing;therapeutic development;therapeutic vaccine;Toxic effect;Transgenic Mice;Vaccination;Vaccine Design;vaccine development;vaccine efficacy;vaccine failure;vaccine platform;vaccine strategy;Vaccine Therapy;Vaccines;Yeasts;young adult

PROJECT_TITLE: Self-assembling Nanofiber Vaccines for Neurodegeneration

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


NIH_SPENDING_CATS: Genetics

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Project Narrative: The proper temporal and spatial regulation of chromatin is key in human development and health, and dysregulation leads to diseases such as diabetes, cancer, heart disease, and developmental, neurological, and immunological disorders. The proposed research project will further our understanding of the molecular mechanisms that alter the structure and accessibility of chromatin. These studies will contribute to fundamental knowledge about mechanisms of gene regulation and how dysregulation leads to disease states.

PI_NAMEs: MORRISON, EMMA ANTONINA (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acylation;Binding;biophysical techniques;Centromere;Chemicals;Chromatin;Chromatin Structure;Chromosomal Stability;Complex;Core Protein;developmental disease;Diabetes Mellitus;Disease;DNA;Epigenetic Process;Gene Expression;Gene Expression Regulation;Genetic;Goals;Health;Heart Diseases;histone modification;Histones;Human Development;human disease;Immune System Diseases;Knowledge;Laboratories;Language;Link;Lysine;Malignant Neoplasms;Metabolic;Metabolic Diseases;Mitosis;Molecular;Molecular Conformation;Nervous System Disorder;NMR Spectroscopy;Nucleosomes;Phase;Post-Translational Protein Processing;Regulation;Research Project Grants;Role;Structure;System;Tail;Translating;Variant

PROJECT_TITLE: The role of histone tails in chromatin structure and gene regulation


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE  Pancreatic cancer has emerged as a major public health problem, and unfortunately, the incidence is rising. Most patients present with advanced tumors, and even those with small, surgically removable tumors ultimately succumb to pancreatic cancer, suggesting that pancreatic tumors spread (or metastasize) even before diagnosis in most people. Thus, new treatments are urgently needed and we propose the following studies to address this important unmet need: 1) To determine why pancreatic tumors behave aggressively and spread to distant sites, and, 2) To develop novel therapeutic approaches to treat, or even prevent, these highly lethal tumors.

PI_NAMEs: JAFFEE, ELIZABETH M.;RESAR, LINDA M S (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Address;Adult;adverse outcome;Alleles;Biological Assay;Cancer Etiology;Cell Line;Cells;Cessation of life;checkpoint therapy;Chromatin;Clinical;Combined Modality Therapy;Cytometry;Cytotoxic Chemotherapy;Data;Desmoplastic;Diagnosis;Distant;efficacy testing;Embryonic Development;Epigenetic Process;Epithelium;FGF19 gene;FGFR4 gene;Fibroblasts;Fostering;Gene Expression;gene function;gene network;Genetic Transcription;Genomics;Goals;Growth Factor Gene;Human;Image;immune cell infiltrate;Immune Evasion;Immunotherapy;Impairment;improved;In Vitro;in vivo;in vivo Model;Incidence;inhibitor;innovation;KPC model;KRASG12D;Lesion;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Modeling;Molecular;molecular subtypes;mouse model;mutant;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenic;Operative Surgical Procedures;Outcome;overexpression;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;pancreatic tumorigenesis;Pathogenesis;Pathway interactions;Patients;Persons;Phenotype;postnatal;Pre-Clinical Model;prevent;Proliferating;Property;Proteins;Public Health;Publishing;receptor;Resources;response;Role;Signal Transduction;single cell analysis;single-cell RNA sequencing;Site;Stromal Neoplasm;synergism;T cell infiltration;Testing;therapeutic target;Tissue Differentiation;transcriptomics;Treatment Efficacy;tumor;tumor growth;tumor initiation;tumor initiators;tumor progression;tumorigenesis;United States;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeting HMGA1 Tumor-Stromal Networks in Pancreatic Carcinogenesis

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Brain development requires the establishment of synaptic connections between neurons, which by mediating data flow and storage in the brain, ultimately underlie cognition and emotion. Adhesion-GPCRs (A-GPCRs) are a large family of cell-adhesion proteins whose complex structures and signaling properties make them among the least understood cell-surface receptors, yet they play important roles in brain development and function and are linked to many human diseases, making them potential therapeutic targets. We will uncover the roles and signaling mechanisms of BAI A-GPCRs in orchestrating the formation, refinement, and plasticity of synaptic connections in brain circuits important for learning and memory; results from this study could impact human health as BAI A-GPCRs are implicated in autism, schizophrenia, bipolar disorder, and cognitive performance.

PI_NAMEs: TOLIAS, KIMBERLY R (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Adhesions;Adult;Affect;Astrocytes;autism spectrum disorder;Axon;axon growth;BAI1 gene;BAI2 gene;BAI3 gene;Binding;Biology;Bipolar Disorder;Brain;C-terminal;Cell Adhesion Molecules;Cell Surface Receptors;Cognition;cognitive ability;cognitive performance;Complex;Cues;Data;Dendrites;Development;Disease;Dissociation;Emotions;Excitatory Synapse;Exhibits;extracellular;Family;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;Health;Hippocampus;Human;human disease;Intellectual functioning disability;interdisciplinary approach;Learning;Length;Ligand Binding;Ligands;Link;Malignant neoplasm of brain;Maps;Mediating;member;Membrane;Memory;Mental Depression;Mitochondria;Modeling;Molecular;mood regulation;N-terminal;neurodevelopment;Neurons;neuropsychiatric disorder;Pathway interactions;Play;Portraits;postsynaptic;presynaptic;Process;Property;Receptor Activation;Regulation;Reporting;response;rho GTP-Binding Proteins;Role;Schizophrenia;Signal Pathway;Signal Transduction;Site;Structure;Synapses;synaptic function;Synaptic plasticity;synaptogenesis;Tail;Testing;therapeutic target

PROJECT_TITLE: BAI Adhesion-GPCRs: Key Regulators of Synapse Development and Plasticity in Health and Disease

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]