NIH_SPENDING_CATS: Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Genetic Testing;Genetics;Human Genome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The vast majority of genetic diseases underlying non-immune hydrops fetalis (NIHF) are missed with standard testing, resulting in an undirected approach to care and substantial risk of morbidity and mortality for the fetus, neonate, and pregnant woman. We propose a prospective, multicenter study applying whole genome sequencing, RNA sequencing, and comprehensive pre- and postnatal phenotyping to identify underlying genetic diseases, expand the perinatal phenotypes of those genetic diseases, improve prenatal diagnostic accuracy, and enable targeted clinical management to optimize outcomes during pregnancy and after delivery. Only with this precision approach will we improve the course for fetuses and families encountering NIHF.

PI_NAMEs: SPARKS, TERESA N (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: accurate diagnosis;Affect;Algorithms;Anemia;Ascites;Autopsy;Bioinformatics;Biometry;Candidate Disease Gene;Caring;Clinical Management;clinically significant;cohort;Collaborations;Collection;Computational Biology;Counseling;Country;Data;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic algorithm;Disease;disease diagnosis;disparity reduction;Early Diagnosis;Edema;Enrollment;Etiology;Evaluation;exome sequencing;experience;Family;fetal;Fetus;Foundations;Future;Genes;Genetic;Genetic Diseases;genetic epidemiology;Genetic Predisposition to Disease;genetic testing;genetic variant;genome sequencing;Genomics;Hydrops Fetalis;improved;improved outcome;in utero;Individual;Inherited;Intrauterine Blood Transfusion;Karyotype;Knowledge;Liquid substance;Medical center;Medical Genetics;Mendelian disorder;Mentored Clinical Scientist Development Program;Molecular Genetics;Morbidity - disease rate;mortality;Multicenter Studies;multidisciplinary;Neonatal Mortality;neonate;novel;novel diagnostics;Outcome;Pathogenicity;Pericardial effusion;Perinatal;Perinatal Care;Perinatology;personalized approach;Phenotype;phenotypic data;Pleural effusion disorder;Positioning Attribute;postnatal;Postnatal Care;Pregnancy;Pregnant Women;Premature Birth;prenatal;Prenatal Diagnosis;prenatal testing;prospective;Race;racial diversity;Reporting;Risk;Sample Size;Severities;Shapes;Skin;stillbirth;Testing;tool;transcriptome sequencing;ultrasound;Variant;whole genome;Work

PROJECT_TITLE: Uncovering the etiologies of non-immune hydrops fetalis through comprehensive genomic analyses and phenotyping

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Childhood Obesity;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: OKLAHOMA CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE This proposal will test how excess glucose and lipid is produced by the liver in children with pediatric nonalcoholic fatty liver disease (NAFLD), whether those events are regulated by specific variations in the amount and location of RNAs and proteins in liver, and whether the concentration of specific micro-RNAs in the blood can be used as a biomarker for NAFLD in pediatric patients.

PI_NAMEs: FRIEDMAN, JACOB E;SHORT, KEVIN R. (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Acceleration;Adolescent;Adult;Affect;Animal Model;Animals;Area;Automobile Driving;Binding;Bioinformatics;Biological Markers;biomarker panel;Blood;Cell Respiration;Child;Childhood;circulating biomarkers;circulating microRNA;Citric Acid Cycle;Classification;clinically significant;Collagen;comparison control;Control Groups;Data;Development;Diagnosis;Disease;Disease Progression;disorder prevention;emerging adult;end stage liver disease;Etiology;Event;Fasting;Fatty acid glycerol esters;Fatty Liver;Fibrosis;Functional disorder;Gene Expression;Genes;Genetic Transcription;Gluconeogenesis;Glucose;Glycerol;Hepatic;Heterogeneity;Histopathology;Imaging Device;imaging modality;Immunoprecipitation;Inflammation;Insulin Resistance;lipid biosynthesis;Lipids;Liver;liver biopsy;Liver diseases;Liver Fibrosis;liver injury;Location;Measures;Mediator;Messenger RNA;Metabolic;Metabolic Pathway;Methods;MicroRNAs;Mitochondria;Molecular;molecular imaging;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel marker;Nutrient;Obesity;obesity in children;Oral;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern;pediatric non-alcoholic fatty liver disease;pediatric patients;Pediatric Surgical Procedures;peer;Population;potential biomarker;Proteins;Resolution;RNA;Role;Sampling;Serum;Severity of illness;Spatial Distribution;Stress;sugar;Testing;therapeutic development;therapeutic target;Time;Tissue imaging;Tissues;tool;Tracer;Transcript;Variant;Very low density lipoprotein;Weight;Youth

PROJECT_TITLE: Understanding the metabolic pathology of pediatric obesity and NAFLD

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: HANOVER

ORG_DEPT: PSYCHIATRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative The proposed activities of the Northeast Node of the National Drug Abuse Treatment Clinical Trials Network (CTN) embrace advances in scientific discovery and research innovations that offer great promise for increasing the reach and effectiveness of treatments for substance use disorders (SUD). These activities reflect a vision for the next iteration of the CTN in the next 5 years. This work will advance translational science in SUD research and markedly reduce the gap between SUD research and clinical practice -- with a focus on scaling-up and sustaining best practices.

PI_NAMEs: MARSCH, LISA A. (contact)

PROGRAM_OFFICER_NAME: BERTZ, JEREMIAH WILLIAM

PROJECT_TERMS: Acceleration;Accident and Emergency department;Achievement;addiction;Alcohols;Artificial Intelligence;Authorization documentation;Behavior Therapy;behavioral health;Bioinformatics;Cannabis;Caring;chronic pain;Clinical;clinical practice;Clinical Treatment;Clinical Trials;Clinical Trials Network;cocaine use;college;Communication;Communities;Community Healthcare;Community Networks;community organizations;comorbidity;Complement;Data;Data Analytics;data privacy;Data Science;design;digital;digital applications;digital data;digital health;digital phenotyping;digital technology;digital treatment;disorder prevention;Drug abuse;experience;Experimental Designs;Federally Qualified Health Center;Fire - disasters;flexibility;Funding;handheld mobile device;Health behavior;health care settings;Health Services Accessibility;Healthcare;high risk population;high school;Human immunodeficiency virus test;implementation science;improved;Individual;Infrastructure;innovation;insight;International;Justice;Lead;Leadership;Link;Maine;marijuana use;Medical;medical specialties;medication compliance;medication for opioid use disorder;meetings;member;Mental disorders;Mental Health;mobile computing;National Clinical Trials Network;National Institute of Drug Abuse;New Hampshire;novel;Opioid;opioid use;opioid use disorder;Patients;personalized health care;Persons;Pharmaceutical Preparations;Pharmacy facility;Policies;predictive modeling;Pregnant Women;Primary Care;Productivity;Provider;Publications;randomized trial;recruit;Research;research and development;Research Infrastructure;Research Methodology;Research Personnel;research study;Resources;Role;Rural;Rural Community;rural setting;scale up;Science;screening;Security;Series;smart watch;social media;special interest group;Stimulant;Strategic Planning;substance use;Substance Use Disorder;substance use treatment;System;Technology;telehealth;Time;Tobacco;Training;Translational Research;treatment disparity;Treatment Effectiveness;United States Food and Drug Administration;Vermont;Vision;wearable sensor technology;Work;Youth

PROJECT_TITLE: Northeast Node of the National Drug Abuse Clinical Trials Network


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Mental Health;Neurosciences;Women's Health Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative How and which brain neural circuits are modulated by female hormones and consequently regulate emotion and behavior across the hormonal cycle are not well understand. In this project, we propose to examine circuit mechanisms whereby a neural pathway whose connectivity changes with the female hormonal cycle regulates social behaviors. Neural circuit dysfunction is at the heart of common neurodegenerative conditions as well as mental illnesses, and our findings will reveal circuit mechanisms underlying behavioral changes across the female hormonal cycle, and they may have the potential to suggest new avenues for research and interventions in common neuro-psychiatric disorders that are regulated by female hormones.

PI_NAMEs: DING, JUN ;SHAH, NIRAO MAHESH (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Acute;Anatomy;Animal Model;Animals;Basic Science;Behavior;behavior influence;Behavioral;Behavioral Paradigm;Brain;Brain region;Cell Nucleus;Cells;Cognitive;Communication;Data;Disease;Electrophysiology (science);Emotions;Estrous Cycle;Estrus;Event;Exhibits;experimental study;Female;Fiber;Fluorescence;Functional disorder;Genetic;Goals;Gonadal Steroid Hormones;Halorhodopsins;Health;Heart;Hormonal;Hormones;Hypothalamic structure;Image;in vivo;in vivo imaging;innovation;insight;Intervention;KISS1 gene;Knock-in;male;Maps;mating behavior;Mental disorders;Molecular;Monitor;Mus;Nerve Degeneration;neural circuit;Neural Pathways;Neurobiology;Neurons;Neuropeptides;neuropsychiatric disorder;neuropsychiatry;neuroregulation;Neurosciences;novel;optogenetics;Output;Ovarian;Ovarian Cycles;Ovarian hormone;Partner in relationship;Pathway interactions;Pattern;Performance;Phase;Photometry;Photons;Physiological;Physiology;postsynaptic;postsynaptic neurons;presynaptic;Progesterone Receptors;Rabies;Reagent;Regulation;Reporter;reproductive;Reproductive Behavior;reproductive function;Reproductive Physiology;Research;Research Proposals;sex;Sex Behavior;sexual dimorphism;Slice;Social Behavior;Social Interaction;Specificity;Synapses;Testing;Translational Research;two-photon;Ventricular;Viral;Woman;Work

PROJECT_TITLE: Connectivity, activity, and function of a hypothalamic pathway in female social behaviors

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Depression;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: Los Angeles

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE  Social connection during pregnancy is a well-established buffer for prenatal stress known to predict better infant and maternal health in the postpartum period. This study examines how social disruption, particularly during the COVID-19 pandemic, affects expectant parents and their subsequent mental health, birth outcomes, and infant development.

PI_NAMEs: SAXBE, DARBY E. (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Affect;Age;Anxiety;Anxiety Disorders;anxiety symptoms;Apgar Score;Behavior;Behavioral;biopsychosocial factor;Birth;Birth Weight;Buffers;Child;Child Health;Child Rearing;Childbirth;cohort;Communities;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Reporting;Data Set;depressive symptoms;Development;Disease;Distress;Economics;Enrollment;Expectancy;experience;Extended Family;Family health status;Fathers;Feeling;Fetal Development;follow-up;Foundations;Fright;Funding;Geographic Locations;Gestational Age;Guidelines;Hair;Health;healthy pregnancy;Height;Hospitals;Hydrocortisone;in utero;Incidence;indexing;Infant;Infant Development;Infant Health;infant temperament;Infection;insight;Knowledge;Link;Location;Loneliness;Long-Term Effects;Low Birth Weight Infant;Maternal Health;Measures;Mental Depression;Mental Health;Modeling;Mood Disorders;Mothers;National Institute of Child Health and Human Development;Natural experiment;neurodevelopment;neuroimaging;Neurosecretory Systems;Outcome;pandemic disease;pandemic impact;Parents;Participant;Patient Self-Report;perceived stress;Personal Satisfaction;Persons;Population;postpartum outcome;Postpartum Period;pre-pandemic;Pregnancy;Pregnant Women;Premature Birth;prenatal;Prenatal care;prenatal stress;protective factors;psychological distress;Readiness;Recovery;recruit;Reporting;Research;resilience;Risk;Risk Factors;Sampling;Schools;Shapes;social;Social Behavior;Social Distance;social factors;Social support;Source;stay-at-home order;Strategic Planning;Stress;stress management;stressor;Temperament;Testing;United States;Woman

PROJECT_TITLE: Prenatal Social Connection and Disruption During the COVID-19 Pandemic: Effects on Maternal and Infant Health


ADMINISTERING_IC: AI

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE (OVERALL)  The Vision of the Seattle Tuberculosis (TB) Research Advancement Center (SEA-TRAC) is to facilitate a decrease in the global burden of TB through training and multi-disciplinary research. SEA-TRAC will accomplish this by catalyzing new avenues of research and training a cadre of new investigators that will make a meaningful impact on the TB epidemic. By the end of the funding period, we expect that SEA-TRAC will have achieved several quantifiable objectives and established itself as a flagship TRAC program, leading new initiatives through interactions with other TRACs and the NIH.

PI_NAMEs: COLER, RHEA N;SESHADRI, CHETAN  (contact);SHERMAN, DAVID R

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Award;Basic Science;Biometry;career development;Charge;Child;Clinical;clinical database;clinical epidemiology;Clinical Research;Clinical Sciences;cohort;Collaborations;Communities;community building;Computational Biology;Consultations;County;Data Science;Data Science Core;design;Development;Direct Costs;Education;Ensure;Environment;Epidemic;Ethnic Origin;Event;Faculty;Fostering;Foundations;Fred Hutchinson Cancer Research Center;Funding;Future;Gender;Grant;Heart;Immune response;Immunology;implementation science;Institution;Interdisciplinary Study;interest;International;Kenya;Knowledge;Lead;Leadership;Medical Research;Mentorship;Methodology;Methods;Microbiology;Modeling;multidisciplinary;Mycobacterium tuberculosis;next generation;programs;Public Health;recruit;Research;Research Institute;Research Methodology;Research Personnel;Science;Scientist;Secure;Services;skills;Strategic Planning;Systems Biology;Training;Translational Research;Translations;Tuberculosis;United States National Institutes of Health;Universities;Vision;Washington

PROJECT_TITLE: Seattle Tuberculosis Research Advancement Center


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Chicago

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Relevance/Narrative It has long been established that DPSCs have a high regeneration capacity. Dentin regeneration is the key factor for maintaining tooth preservation following infection or injury. Understanding the biological mechanisms of the odontogenesis/dentinogenesis and the role of inflammation in this process are required for successful DPSC engineering strategies. The scientific knowledge obtained from this project will provide a foundation for creating therapeutic tools that target DPSC during dentin-pulp complex regeneration.

PI_NAMEs: CHUNG, SEUNG  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Ablation;Address;Adult;Affect;Binding;Biological;C5a anaphylatoxin receptor;C5AR2 gene;CCAAT-Enhancer-Binding Proteins;Cell Culture Techniques;Cells;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;Complement;Complement 5a;Complement Receptor;complement system;Complex;cytokine;Dental caries;Dental Pulp;Dental Pulp Capping;Dentin;Dentin Formation;Dentinogenesis;Dentition;engineered stem cells;Event;Foundations;Future;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;improved;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammatory;Injury;Invaded;Investigation;Knockout Mice;Knowledge;Link;Mediating;mineralization;Minerals;Modeling;Molecular;mouse model;Mus;Natural regeneration;novel;novel therapeutic intervention;Odontoblasts;Odontogenesis;p38 Mitogen Activated Protein Kinase;Pathologic;Pathway interactions;pharmacologic;Play;Population;preservation;Process;process improvement;promoter;Proteins;Proteolysis;Public Health;Reaction;receptor;recruit;Regenerative capacity;Regenerative response;Regulatory Pathway;repaired;Repression;response;response to injury;Role;screening;Series;Signal Pathway;Signal Transduction;Small Interfering RNA;stem cell biology;stem cell differentiation;stem cell function;stem cells;Therapeutic;Therapeutic Intervention;tissue regeneration;TNF gene;tool;Tooth Components;Tooth Injuries;Tooth structure;Transactivation;transcription factor;Transcriptional Regulation;Work

PROJECT_TITLE: Role of complement receptor C5L2 in reparative dentinogenesis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

PI_NAMEs: SESHADRI, CHETAN  (contact)

PROJECT_TERMS: Advisory Committees;advocacy organizations;Advocate;Award;Awareness;Collaborations;Communication;Communities;Databases;Development;Developmental Process;Educational workshop;Ensure;Environment;Epidemic;equipment acquisition;Feedback;Fostering;Funding;global health;Goals;Human Resources;Income;Institution;Interdisciplinary Study;Lead;Leadership;Learning;Maintenance;meetings;member;Mission;Monitor;multidisciplinary;National Institute of Allergy and Infectious Disease;next generation;Personnel Management;Persons;Policies;Policy Maker;Procedures;Process;Productivity;programs;recruit;Research;Research Personnel;Resources;Science;Service provision;Services;Site;Strategic Planning;success;Surveys;symposium;synergism;Training;Tuberculosis;Vision;web site;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Data Science;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

PI_NAMEs: HAWN, THOMAS R (contact)

PROJECT_TERMS: Address;Award;Basic Science;career;Clinical;clinical epidemiology;Clinical Sciences;Clinical Trials;co-infection;Collaborations;Communication;Computational Biology;Country;Creativeness;Data;Data Science;Data Science Core;design;Development;Distance Learning;Doctor of Philosophy;E-learning;Education;Educational Curriculum;Educational workshop;Environment;Epidemic;Epidemiology;Faculty;Financial Support;Fostering;Funding;Future;Goals;graduate student;Grant;Grant Review;high school;High School Outreach;HIV;HIV/TB;Immunology;implementation science;Individual;Infrastructure;Institution;International;Kenya;Knowledge;Leadership;Manuscripts;meetings;Mentors;Microbiology;Minority Groups;next generation;online course;Outcome;outreach program;Postbaccalaureate;Postdoctoral Fellow;programs;Publications;recruit;Research;Research Personnel;Research Training;Scholars Program;Scientist;Series;skills;South Africa;success;symposium;Training;Training Programs;Translational Research;Tuberculosis;undergraduate research;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Wages;web site;Work;working group;Writing

PROJECT_TITLE: Development Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Data Science;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

PI_NAMEs: MA, SHUYI  (contact)

PROJECT_TERMS: Agreement;Algorithms;Applications Grants;assay development;bioinformatics tool;Biological;Biology;Biometry;Clinical;Clinical Research;Cloud Computing;Collaborations;Communication;Communities;community building;complex data;Computer Analysis;computer scientist;computerized data processing;computing resources;Consultations;cost;Data;Data Analyses;data integration;data management;Data Science;Data Science Core;Data Scientist;Data Set;data tools;data visualization;Development;Environment;Epidemiologist;Epidemiology;Event;experience;Faculty;Fostering;Genes;Goals;Grant;Hour;Image Analysis;improved;industry partner;Institution;Laboratories;Laboratory Research;Laboratory Scientists;Learning;literacy;mathematical model;member;Modeling;Monitor;multidimensional data;multidisciplinary;Multiomic Data;novel;Outcome;Output;pandemic disease;Pathway Analysis;Pathway interactions;Peer Review;Phase;Play;power analysis;Process;Productivity;Reproducibility;Research;Research Activity;Research Design;Research Personnel;Research Support;Role;Science;Scientist;Services;single cell analysis;software development;Statistical Data Interpretation;Statistical Methods;structural biology;Structure;success;symposium;Systems Biology;tool;Training;Tuberculosis;tuberculosis diagnostics;Vaccines;virtual;Visualization;Vocabulary;Wages;Work

PROJECT_TITLE: Data Science Core


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: Proper regulation of gene expression is essential to the development and health of all organisms. The DNA in each eukaryotic cell, found as chromatin, plays an integral part in this gene regulation (transcription initiation and how genes are spliced to form different protein isoforms). Furthermore, knowing how chromatin structure controls gene regulation in normal development and in response to environmental insults would be helpful for new diagnostic and therapeutic tools.

PI_NAMEs: FONDUFE-MITTENDORF, YVONNE NSOKIKA (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Affect;Amino Acids;Architecture;Arsenic;arsenic-induced carcinogenesis;Automobile Driving;Binding Proteins;Biochemical;Bioinformatics;Biology;biophysical analysis;Biophysics;cancer type;carcinogenesis;Cell Culture Techniques;Cell Proliferation;cell transformation;cell type;Cells;ChIP-seq;Chromatin;Chromatin Structure;Compensation;contaminated water;Deposition;Development;differential expression;Disease;DNA;DNA Methylation;drinking;Epigenetic Process;epigenome;Epithelium;Etiology;Eukaryotic Cell;experimental study;Exposure to;functional genomics;Gene Activation;Gene Expression;Gene Expression Regulation;gene function;gene repression;Genes;Genome;genome-wide;Genomic DNA;genomic locus;Genomics;Growth;Health;Histone H2B;Histones;Human;In Vitro;in vivo;insight;knock-down;lens;Location;Malignant Neoplasms;Mammalian Cell;Maps;Mass Spectrum Analysis;Mediating;Mesenchymal;Messenger RNA;metaplastic cell transformation;Methylation;Modification;Molecular;mutant;Mutation;Neoplastic Cell Transformation;Normal Cell;novel;novel diagnostics;novel therapeutics;Nucleosomes;Oncogenic;oncohistone;Organism;overexpression;Pathology;Persons;Play;pollutant;Poly(A) Tail;Positioning Attribute;Post-Translational Protein Processing;Process;promoter;Protein Isoforms;Proteins;Recurrence;response;Risk;Role;Series;Site;Spliced Genes;stem;Structure;System;Testing;Therapeutic;Tissue-Specific Gene Expression;tool;toxicant;Toxicology;Transcript;transcription factor;Transcription Initiation;Tumor Biology;tumor progression;tumorigenesis;Variant;Work;World Health Organization;Xenograft Model

PROJECT_TITLE: Molecular mechanisms of iAs-mediated carcinogenesis through the lens of histone H2B variants

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


PI_NAMEs: PARISH, TANYA  (contact)

PROJECT_TERMS: accurate diagnostics;Address;Area;Basic Science;Biological Sciences;Biology;career;Child;combat;Communities;Consultations;Dedications;Development;Diagnostic;Educational Curriculum;Emergency Situation;Epidemic;Equipment;experience;fighting;Foundations;Fred Hutchinson Cancer Research Center;Funding;Goals;Hour;Immune response;Immunology;Infection;insight;interest;investigator training;Measures;Methods;Microbiology;Mycobacterium tuberculosis;next generation;novel strategies;novel therapeutics;Outcome;Output;pathogen;Pathogenesis;prevent;Process;programs;recruit;Research;research facility;Research Institute;Research Personnel;Research Project Grants;Resources;Scientist;Services;skills;Sterile coverings;success;Talents;Technology;Thinking;tool;Training;Treatment Protocols;Tuberculosis;Tuberculosis diagnosis;Universities;Vaccines;Washington;Work

PROJECT_TITLE: Basic Science Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Stem-like cancer cells are the “roots” of aggressive tumors, as they seed metastasis and recurrence; devising a way to kill this population of cells or prevent them from being generated remains a significant clinical challenge. We identified Oncostatin M as a key driver and maintenance factor for these stem-like cells and as a suppressor of the immune system. Here, we’ll define novel signaling effectors activated by the Oncostatin M Receptor, providing us with an extraordinary opportunity to develop combination therapies aimed at suppressing the generation and maintenance of invasive, drug tolerant cancer cells and activating the immune system to improve current therapies.

PI_NAMEs: JACKSON, MARK W. (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: aggressive breast cancer;Binding;Breast Cancer Cell;breast cancer metastasis;cancer cell;cancer cell differentiation;cancer invasiveness;cancer recurrence;CBL gene;Cell Culture Techniques;Cells;chemotherapy;Clinical;Combined Modality Therapy;Complex;cytokine;Drug Tolerance;Equilibrium;Gene Expression;Generations;Genes;Genetic Transcription;Goals;Human;Immune;Immune checkpoint inhibitor;Immune system;immune system function;Immunosuppressive Agents;Immunotherapy;improved;improved outcome;Inflammatory;Interferon Suppression;Interferon-beta;Interferons;Link;MADH3 gene;Maintenance;Mediating;Mesenchymal;mimicry;Molecular;mouse model;nanoparticle;Neoplasm Metastasis;novel;novel therapeutic intervention;oncostatin M;Patient-Focused Outcomes;Patients;Phosphorylation;Population;prevent;Production;programs;promoter;receptor;Recurrence;Recurrent disease;Recurrent tumor;Relapse;Repression;Resistance;sensor;Signal Transduction;standard of care;STAT1 gene;STAT2 gene;STAT3 gene;stem;stem-like cell;Testing;therapy resistant;transcription factor;Treatment Failure;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor initiation;tumor microenvironment;Tumor Promotion;Viral

PROJECT_TITLE: Targeting Oncostatin M-Receptor to Suppress Metastasis and Therapy Failure

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

PI_NAMEs: HORNE, DAVID J. (contact)

PROJECT_TERMS: Africa South of the Sahara;Area;Asia;Authorization documentation;biobank;Biological;Clinical;clinical database;clinical epidemiology;Clinical Research;Clinical Sciences;Clinical Trials;cohort;Collaborations;Collection;Consultations;Country;Data;Databases;Diagnostic;Disease;disease model;Educational process of instructing;Faculty;Fostering;global health;Goals;graduate student;Grant;implementation science;Individual;Institution;International;Latin America;meetings;Mentors;Methodology;Methods;Minority Groups;Modeling;multidisciplinary;novel;Outcome;Persons;Pharmaceutical Preparations;Pilot Projects;Productivity;programs;prospective;Protocols documentation;Public Health;Research;Research Activity;Research Methodology;Research Personnel;Research Support;Resources;sample collection;Series;Services;Site;Specimen;Structure;summer research;Training;Translational Research;Translations;transmission process;Travel;Tuberculosis;Tuberculosis Vaccines;Underrepresented Minority;Universities;Vaccines;Washington;working group

PROJECT_TITLE: Clinical and Translational Science Core


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: MADISON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Peptide hormones are signaling molecules that are packaged into secretory granules for secretion into the bloodstream by endocrine cells. Intracellular degradation of peptide hormones occurs when secretory granules merge with degradative organelles called lysosomes. This work will analyze a tethering factor called Munc13-4 that directs the merge of secretory granules with lysosomes, which will be relevant for understanding lysosomal storage diseases such as mucolipidosis type IV.

PI_NAMEs: MARTIN, THOMAS F. J. (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Acceleration;Acute;Affect;AGFG1 gene;Autophagocytosis;Biogenesis;Biological Assay;Biological Availability;Blood Circulation;Bypass;Cell membrane;cell type;Cells;Cellular Assay;Cryoelectron Microscopy;Dedications;Endocrine;Endosomes;Event;Exhibits;Exocytosis;Fluorescence;Follow-Up Studies;Ganglioside Sialidase Deficiency Disease;Golgi Apparatus;Hormone secretion;Hormones;Hybrids;Image;inhibitor;Islets of Langerhans;knock-down;Knockout Mice;Knowledge;knowledge base;Lighting;Liposomes;Lysosomal Storage Diseases;Lysosomes;Mediating;Membrane;Membrane Fusion;Molecular;molecular marker;Multivesicular Body;Nature;Negative Staining;Neuroendocrine Cell;Neurosecretory Systems;Organelles;Outcome Study;Pathway interactions;peptide hormone;peptide hormone biosynthesis;Phenotype;Physiological;Pituitary Gland;Process;prohormone;Property;protein biomarkers;protein complex;Proteins;reconstitution;recruit;Regulation;Role;Secretory Vesicles;Signaling Molecule;small hairpin RNA;Small Interfering RNA;small molecule;SNAP receptor;Structure;Testing;trafficking;Ubiquitination;Work

PROJECT_TITLE: Munc13-4 Regulates Peptide Hormone Degradation in Neuroendocrine Cells

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_NAME: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE

PHR: Public Health Relevance The proposed postdoctoral training program in vision and rehabilitation research will have a positive and direct impact on public health. The program is designed to train fellows to gain a deep understanding of vision and visual impairment to develop novel models of visual function that provide insights into disease prevention, monitoring and treatment, interventions for binocular vision disorders, rehabilitation techniques and assistive devices. Postdoctoral fellows emerging from the program will be able to launch their own independent research careers. Because research at Smith-Kettlewell is motivated by clinical problems, it is highly likely that our fellows will make significant contributions to vision health during and after their training.

PI_NAMEs: VERGHESE, PREETI  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: post-doctoral training;Vision research

PROJECT_TITLE: Postdoctoral Training in Vision Research


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative: Self-renewal of the intestinal lining continuously generates two major cell types: absorptive and secretory. While the emergence of absorptive enterocytes from intestinal stem cells is increasingly well understood, mechanisms behind the precise designation of diverse secretory cells remain largely unknown. We will use state-of-the-art genetic and molecular tools to investigate how the intestinal lining maintains a proper census of the myriad secretory cell types that serve vital physiologic functions and are often disturbed in inflammatory and other intestinal disorders.

PI_NAMEs: SHIVDASANI, RAMESH A (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Abbreviations;Address;Attention;Binding Sites;Biological Assay;Bone Morphogenetic Proteins;Bypass;Cell Differentiation process;cell type;Cells;Censuses;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Colon;Complement;crypt cell;Cues;Data;Defect;Development;Distant;Doxycycline;Embryo;Enhancers;Enterobacteria phage P1 Cre recombinase;Enterochromaffin Cells;Enterocytes;Enteroendocrine Cell;Epidermal Growth Factor;Epigenetic Process;Epithelial Cells;Epithelium;Estrogen Receptors;Event;Experimental Models;experimental study;Fibroblasts;Fluorescence-Activated Cell Sorting;gain of function;Gastrointestinal Diseases;Genes;Genetic;Genetic study;Genetic Transcription;Goblet Cells;Grant;Homologous Gene;Human;human model;In Vitro;in vitro Model;in vivo;Inflammatory;insight;Intestinal Diseases;Intestines;Investigation;Knockout Mice;Knowledge;Label;Lateral;light scattering;Liquid substance;Logic;loss of function;LoxP-flanked allele;Maps;Mediating;Messenger RNA;Metabolic;Metaplasia;Modeling;Molecular;Morphology;mouse genetics;Mouse Strains;Mus;Mutant Strains Mice;notch protein;novel;Paneth Cells;Phenotype;Physiological;precursor cell;Process;progenitor;programs;Property;Publishing;Puromycin;recruit;Regulatory Element;Reporting;Resistance;Resolution;response;Rest;RNA;RUNX1 gene;Secretory Cell;self-renewal;Seminal;Signal Pathway;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Small Intestines;SOX4 gene;Specific qualifier value;stem cells;stemness;System;Tamoxifen;Testing;Time;Tissues;tool;transcription factor;Transcriptional Regulation;Transposase;Vertebrates;Villus;WNT Signaling Pathway

PROJECT_TITLE: Transcriptional control and enhancer recruitment in mouse and human intestinal secretory differentiation

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stroke

ORG_CITY: TALLAHASSEE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative: The proposed work will engineer and characterize extracellular vesicles secreted by 3-D brain region-specific organoids derived from human induced pluripotent stem cells and investigate the impacts of paracrine signaling on neural function in vitro and in vivo for ischemic stroke therapy.

PI_NAMEs: LI, YAN  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: 3-Dimensional;Adult;American;Anabolism;analog;Animals;Anti-Inflammatory Agents;Attenuated;Behavior;beta catenin;Binding;Biodistribution;Brain;Brain Ischemia;Brain region;brain tissue;Caspase;Cell Survival;Cells;Cellular Structures;Clinical;Confocal Microscopy;cytotoxic;Derivation procedure;Development;differentiation in vitro;Distal;effective therapy;Electron Microscopy;Electrophysiology (science);Embryo;Encapsulated;Engineering;Environment;Enzymes;Exhibits;exosome;extracellular;Extracellular Matrix;extracellular vesicles;Goals;Heparan Sulfate Proteoglycan;Heparin;Heparitin Sulfate;hindbrain;Histologic;Histology;Human;human induced pluripotent stem cells;Hyaluronic Acid;Hydrogels;improved;In Situ;In Vitro;in vivo;in vivo imaging;induced pluripotent stem cell;Inflammatory;Injections;Injury;injury recovery;Ischemia;Ischemic Brain Injury;Ischemic Stroke;Knowledge;Label;Liquid Chromatography;Magnetic Resonance Imaging;Membrane;Mesenchymal Stem Cells;MicroRNAs;microvesicles;Middle Cerebral Artery Occlusion;miRNA expression profiling;Monitor;monolayer;Morphology;nanoparticle;Nerve Regeneration;nerve stem cell;neural;neurodevelopment;neurogenesis;Neurons;neuropathology;Neurophysiology - biologic function;neuroprotection;non-invasive imaging;non-invasive monitor;novel therapeutics;Organoids;Outcome;overexpression;Oxidative Stress;Paracrine Communication;Pathway interactions;pharmacologic;Predisposition;Prosencephalon;Proteins;Proteomics;Rattus;Reactive Oxygen Species;receptor expression;Recovery;Recovery of Function;Research;Rodent;Signal Pathway;Signal Transduction;Site;spheroids;stem cell therapy;stem cells;Stroke;stroke model;stroke therapy;Structure;System;tandem mass spectrometry;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic miRNA;tissue regeneration;tissue repair;transcriptome;Transfection;Transplantation;TSG101 gene;Undifferentiated;uptake;Vesicle;virtual;Western Blotting;WNT Signaling Pathway;Work

PROJECT_TITLE: Engineering Extracellular Vesicles of Human Brain Organoids for Stroke Therapy

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE To survive in a changing environment, all cells and organisms must be able to adapt while preserving both metabolic homeostasis and genome integrity. Whether perturbations in genome integrity is sensed by cells to regulate growth factor signaling or DNA repair is not well-understood. Using a powerful viral model system, cutting-edge microscopy, and genomics/proteomics, we will address this current knowledge gap to understand fundamental DNA damage response processes as it relates to genome integrity in different cell types.

PI_NAMEs: HUANG, TONY TUNG (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;Area;Biological Models;cancer therapy;Cell Cycle Checkpoint;Cell Nucleus;Cell Surface Receptors;cell type;Cells;Cytoplasm;Detection;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA Repair Disorder;DNA replication fork;Environment;extracellular;Gene Expression;Genome;genome integrity;Genome Stability;genome-wide;genome-wide analysis;Genomic Instability;Genomics;Genotoxic Stress;genotoxicity;Goals;Growth;Growth Factor;Homeostasis;human disease;innovation;Interphase Cell;Knowledge;Ligation;Link;Maintenance;malignant neurologic neoplasms;Mediating;Metabolic;Microscopy;Molecular;Nervous System Disorder;novel;Nuclear;Okazaki fragments;Organism;Pathway interactions;PIK3CG gene;preservation;Process;programs;Proteomics;Proto-Oncogene Proteins c-akt;Receptor Protein-Tyrosine Kinases;Recovery;Research;response;Role;Signal Pathway;Signal Transduction;single molecule;Site;Source;Stress;superresolution microscopy;Techniques;Testing;Viral

PROJECT_TITLE: Understanding the mechanistic role of genome stability pathways in regulating cell homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Kidney Disease;Prevention

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE. Drugs are responsible for roughly one-quarter of acute kidney injury (AKI) cases, and antibiotics are implicated in approximately half of these events. Broad spectrum antibiotics are frequently used in hospitalized patients with vancomycin plus piperacillin/tazobactam being one of the most commonly prescribed combinations. Over 20% of patients treated with this combination develop AKI with mechanism postulated to be related to oxidative stress. Targeting the nuclear factor erythroid 2–related factor 2 transcriptional pathway has great potential to up-regulate antioxidant responses and restore mitochondrial membrane potential. This study will evaluate whether melatonin, a hormonal dietary supplement, decreases AKI in a human clinical trial and verify its mechanism in vitro and in vivo.

PI_NAMEs: BRUNETTI, LUIGI  (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Antibiotics;Antioxidants;Apoptotic;Back to Sleep;Biodistribution;Bioenergetics;CASP3 gene;Cells;Clinical;clinical decision-making;Clinical Trials;cost;Creatinine;cytochrome c;Data;Death Rate;Development;dietary supplements;Dose;Drug Combinations;Early identification;Enrollment;Evaluation;Event;exposed human population;Exposure to;Gene Expression Profiling;Genetic Transcription;Health;Healthcare;Hormonal;Hospital Mortality;Hospitalization;Human;hypnotic;IL18 gene;improved;In Vitro;in vivo;Incidence;Infection;Injury to Kidney;Institution;Interferons;Interleukin-1;Intervention;Kidney;Literature;Mediating;Melatonin;Membrane Potentials;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial membrane;modifiable risk;Molecular;nephrotoxicity;novel;novel marker;nuclear factor-erythroid 2;Oxidative Stress;Pathway interactions;Patients;Pharmaceutical Preparations;Piperacillin;Piperacillin-Tazobactam;Placebos;Plasma;post gamma-globulins;pre-clinical;preservation;prevent;Prevention;Property;prospective;Prospective Studies;Protons;Proximal Kidney Tubules;Randomized;Randomized, Controlled Trials;Reporting;Resources;response;restoration;Risk;Risk Factors;Risk Reduction;Role;sedative;Serum;Signal Transduction;sleep quality;Stress;targeted biomarker;Tazobactam;Testing;Time;TNF gene;transcriptomics;translational approach;urinary;Vancomycin;Whole Blood;zolpidem

PROJECT_TITLE: Mechanistic evaluation of melatonin as a protectant against antibiotic associated kidney injury

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative  This proposed project is relevant to public health by: 1) identifying industries, occupations, and worker populations at high risk for work injuries and illnesses in the southeast region of the United States; 2) assessing risk factors, trends, and emerging occupational safety and health issues; 3) improving and enhancing timely occupational injury and illness surveillance systems in the southeast region; and 4) working with regional industrial, academic, governmental, and organizational partners to intervene to reduce workplace illnesses and injuries.

PI_NAMEs: SANDERSON, WAYNE T. (contact)

PROJECT_TITLE: SouthON Conference Grant

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


NIH_SPENDING_CATS: Cancer;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Prostate Cancer;Rare Diseases;Urologic Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE The protein kinase Aurora A binds to and stabilizes the oncogenic transcription factors c-Myc and N-Myc that are key drivers in a large subset of human cancers. This project aims to understand how Aurora A binds to c- Myc and N-Myc and how to disrupt these interactions with Aurora A inhibitors that trigger structural changes to block binding and promote c-Myc and N-Myc degradation in cancer.

PI_NAMEs: LEVINSON, NICHOLAS MARK (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Active Sites;Affect;Affinity;Agreement;Animal Model;Area;aurora kinase A;Binding;Binding Proteins;Binding Sites;c-myc Genes;cancer cell;Cancer cell line;cancer therapy;Cell Death;cell growth;Cell Line;Cells;Centrosome;Clinical;clinical candidate;Clinical Trials;Complex;Computer Models;Data;Development;Disease;drug development;Electrons;Elements;Eukaryotic Cell;Exhibits;experimental study;Family;Fluorescence Resonance Energy Transfer;Goals;high risk;Human;In Vitro;Infant;inhibitor;insight;kinase inhibitor;Libraries;Magnetic Resonance Spectroscopy;Malignant neoplasm of liver;Malignant Neoplasms;Measurement;Measures;Mitotic;Modality;Molecular;Molecular Conformation;molecular modeling;Motion;multicatalytic endopeptidase complex;MYC Family Protein;MYCN gene;N-Myc Protein;N-terminal;nanosecond;Neuroblastoma;neuroblastoma cell;Neuroendocrine Prostate Cancer;next generation;Oncogenes;Oncogenic;Oncoproteins;overexpression;Paper;Patients;Phosphorylation;Phosphotransferases;Positioning Attribute;prevent;Prognosis;programs;prostate cancer cell line;Protein Kinase;Proteins;Proto-Oncogene Proteins c-myc;Publishing;Regulatory Element;Resolution;response;Roentgen Rays;scaffold;sensor;Series;Shapes;Signal Transduction;SKP Cullin F-Box Protein Ligases;small molecule inhibitor;Solid Neoplasm;Spectrum Analysis;Structure;success;Testing;Therapeutic;therapeutic target;Time;tool;transcription factor;tumor;Ubiquitination;Work;X-Ray Crystallography

PROJECT_TITLE: Targeting allosteric scaffolding functions of Aurora kinase A in cancer

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Healthy cells maintain their DNA within intact chromosomes but in some circumstances such as aging, cells release small linear extrachromosomal DNA fragments that are toxic. Extrachromosomal DNA may result in inflammation and severe diseases and it can be pasted into chromosomal breaks leading to gene inactivation. We aim to understand currently undefined mechanisms of how cells generate small extrachromosomal DNA fragments, an essential step toward designing therapeutic approaches in the future.

PI_NAMEs: IRA, GRZEGORZ A (contact)

PROJECT_TERMS: Affect;Aging;aging related;Antibodies;Attenuated;Award;Cell Aging;Cell Death;Cell Nucleus;Cells;Chromosomal Breaks;Chromosomes;Chronic;Complementary DNA;Data;design;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Structure;ds-DNA;endonuclease;Enzymes;Event;extrachromosomal DNA;Foundations;Frequencies;Future;Gene Silencing;Generations;Genes;Genetic Recombination;Genome;Genome Stability;Genomic Instability;Goals;Grant;Heart failure;Homeostasis;Human;human disease;infancy;Inflammation;Inflammatory Response;Innate Immune Response;Iron;Lead;Ligation;Malignant Neoplasms;Maps;Mediating;Membrane Fusion;Methodology;Methods;Mitochondria;Mitochondrial DNA;mitochondrial membrane;Monitor;mutant;Nature;Nerve Degeneration;Nonhomologous DNA End Joining;Nuclear;nuclease;Organism;Parkinson Disease;Pathway interactions;Pattern;prevent;Production;protein misfolding;Regulation;repaired;Retrotransposition;Retrotransposon;Ribosomal DNA;Role;Saccharomyces cerevisiae;Single-Stranded DNA;Site;Source;System;Telomere Shortening;Testing;Therapeutic;tumor;Work;Yeasts

PROJECT_TITLE: MECHANISM AND REGULATION OF DNA RECOMBINATION IN SACCHAROMYCES CEREVISIAE

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Contraception/Reproduction;Depression;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Women's Health Research

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative Postpartum depression is one of the most common complications of childbirth and is associated with poor maternal/child outcomes. The underlying pathophysiology of postpartum depression is largely unknown, creating an obstacle to developing improved treatments. This study will determine the relationships between sex steroids, brain chemistry and brain circuitry in women with postpartum depression, healthy postpartum women and healthy women during the follicular phase of the menstrual cycle to better understand what causes postpartum depression so that novel treatments may be developed and tested.

PI_NAMEs: DELIGIANNIDIS, KRISTINA MARIE (contact)

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: Address;Adverse effects;Affect;Allopregnanolone;antenatal;Anterior;anti-depressive agents;Behavioral;Biological Markers;Blood;Blood specimen;Brain Chemistry;brain circuitry;Brain region;Cessation of life;Child;Childbirth;cingulate cortex;Cognitive;cohort;Data;Dedications;Depressed mood;Development;Emotional;Estradiol;Event;Female;Functional disorder;Functional Magnetic Resonance Imaging;Future;gamma-Aminobutyric Acid;Glutamates;Goals;Gonadal Steroid Hormones;Hamilton Rating Scale for Depression;hormonal contraception;Image;improved;indexing;Lead;Magnetic Resonance Spectroscopy;Major Depressive Disorder;Measures;Mediator;Menstrual cycle;Mental Depression;Molecular;Moods;Mothers;National Institute of Mental Health;neural circuit;neurochemistry;neuroimaging;Neurosecretory Systems;neurosteroids;new therapeutic target;non-smoker;novel;Observational Study;Outcome;Perinatal;Personal Satisfaction;Pharmacotherapy;Plasma;Postpartum Depression;Postpartum Period;Postpartum Women;predicting response;Prefrontal Cortex;Pregnancy;pregnenolone sulfate;Prevalence;proliferative phase Menstrual cycle;prospective;reproductive;Research;Research Priority;Rest;Scanning;Selective Serotonin Reuptake Inhibitor;Severities;Spectrum Analysis;Suicide;Techniques;Testing;tetrahydrodeoxycorticosterone;therapeutic target;Visit;Withdrawal;Woman;Women's prevalence

PROJECT_TITLE: Relationships between Neuroactive Steroids, GABA and Glutamate MRS and Connectivity of the Default Mode Network in Postpartum Depression


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Infectious Diseases;Precision Medicine;Prevention;Radiation Oncology

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The proposed clinical research aims to validate the use of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters as FDA BEST-defined monitoring biomarkers to monitor the natural history of radiation-associated bone and soft tissue injury and subsequent long-term oral morbidity due to radiation- associated damage (e.g., dry mouth, swallowing difficulty, and jawbone injury/fracture). The work is relevant to public health because of (1) the epidemic rise in HPV-associated oral malignancies, and because this represents (2) the development of the first FDA BEST-defined monitoring biomarker of any kind for oral sequelae of cancer therapy, generally, and the first-ever validated FDA BEST-defined monitoring imaging biomarker of any dental disease process. The innovative research described in this proposal can drive significant change in clinical practice for head and neck cancer by improving survivorship through normal tissue sparing and prevention of long-term toxicity, while maintaining excellent disease control, which always represents a major healthcare challenge.

PI_NAMEs: FULLER, CLIFTON DAVID;LAI, STEPHEN Y (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Abate;Acute;Adjuvant;Algorithms;American;Award;Benchmarking;Biological Markers;biomarker validation;Blood Vessels;bone;bone healing;Bone Injury;Bone Tissue;Cancer Survivorship;cancer therapy;candidate marker;Caring;Categories;Chronic;Clinical;clinical practice;Clinical Research;Communities;Complication;Computer software;contrast enhanced;craniofacial;Data;Data Analyses;Deglutition;Deglutition Disorders;Dental;Development;Diagnosis;diagnostic biomarker;Disease;Disease Surveillance;disorder control;Dose;Drug Kinetics;Drug Monitoring;Early Diagnosis;effectiveness evaluation;Ensure;environmental agent;Epidemic;Exhibits;experience;Exposure to;Fracture;Funding;Habilitation;Head and Neck Cancer;Health;Healthcare;HPV positive;Human Papillomavirus;Image;imaging biomarker;improved;in vivo;Incidence;Individual;Injury;innovation;Institution;interest;Intervention;Investigation;Knowledge;Letters;Life Expectancy;life span;long-term sequelae;Magnetic Resonance Imaging;Malignant Neoplasms;Mandible;Mandibular Injuries;Masticatory muscles;Measures;Medical;Mission;Monitor;Morbidity - disease rate;mortality;multimodality;Muscle;National Institute of Dental and Craniofacial Research;Natural History;Necrosis;Normal tissue morphology;open source;Oral;oral HPV-positive head and neck cancers;Organ;Organ Preservation;Osteoradionecrosis;Outcome;Outcome Measure;Parotid Gland;patient biomarkers;patient population;patient stratification;Patients;Performance;population based;predicting response;Prevention;Preventive;Process;Prognosis;programs;prospective;Public Health;Qualifying;Quality of life;quantitative imaging;Radiation;radiation effect;Radiation therapy;Research;Research Design;Resolution;Risk;Salivary Glands;Secure;side effect;soft tissue;Soft Tissue Injuries;Source;Staging;standard of care;Standardization;Statistical Models;Structure;surrogacy;Surrogate Endpoint;Surrogate Markers;Survivors;survivorship;Symptoms;System;Testing;Therapeutic Intervention;tissue injury;Tissues;tool;Tooth Diseases;Toxic effect;Translating;treatment response;treatment strategy;Treatment-related toxicity;United States National Institutes of Health;usability;Validation;validation studies;Work;working group;Xerostomia

PROJECT_TITLE: Quantitative Imaging Biomarker Prospective Validation of Dynamic Contrast-Enhanced MRI as a Metric of Orodental Injury After Radiotherapy (QI-ProVE-MRI)


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prostate Cancer;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Current diagnostic strategies can fail to accurately detect and classify clinically significant prostate cancer, leading to detrimental overtreatment and undertreatment. This research project aims to jointly develop and integrate innovative quantitative magnetic resonance imaging (MRI) techniques and artificial intelligence algorithms to achieve significantly improved accuracy for detection and classification of clinically significant prostate cancer. The new MRI- based artificial intelligence will be a transformative technology to reduce unnecessary prostate biopsies and enhance decision making for patient management to avoid overtreatment and undertreatment of prostate cancer.

PI_NAMEs: SUNG, KYUNG HYUN  (contact);WU, HOLDEN H

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: Area;Artificial Intelligence;artificial intelligence algorithm;Biopsy;cancer classification;Cancer Etiology;Cancer Patient;Cessation of life;Classification;Clinical;clinically significant;comorbidity;contrast enhanced;convolutional neural network;Data;Decision Making;deep learning model;design;Detection;diagnostic strategy;Diffusion;Diffusion Magnetic Resonance Imaging;diffusion weighted;Gleason Grade for Prostate Cancer;Goals;Health Care Costs;Histologic;Histopathology;Image;Image Enhancement;Imaging Techniques;improved;Incidence;Indolent;Information Systems;innovation;Interobserver Variability;Label;Lesion;Life;machine learning classification;Magnetic Resonance Imaging;male;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;men;Methods;Modeling;Non-Invasive Detection;novel;overtreatment;Patients;Performance;Phase;Predisposition;prisma;prospective;Prostate;prostate biopsy;Prostate Cancer therapy;Radiology Specialty;Reporting;Reproducibility;Research Project Grants;ROC Curve;Scanning;Screening for Prostate Cancer;Sensitivity and Specificity;standard of care;Standardization;synergism;System;Techniques;Technology;Texture;Uncertainty;United States;Validation;Variant

PROJECT_TITLE: Integrating Quantitative MRI and Artificial Intelligence to Improve Prostate Cancer Classification

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative: The overall goal of our research is to uncover the molecular and cellular mechanisms by which mTOR signaling is spatially regulated and to elucidate the contribution of subcellular mTORC1 signaling to tumorigenesis and cancer therapy resistance. Persistent activation of the PI3K/mTOR signaling circuitry is the most frequent dysregulated signaling mechanism in oral squamous cell carcinoma (OSCC), a disease that results in ~300,000 deaths each year worldwide, with 5-year survival estimates of approximately 60%, despite aggressive multimodality therapies. Unravelling the function and regulation of subcellular mTORC1 signaling should offer a path toward selective targeting of pathway components, yielding therapies with reduced toxicity and resistance.

PI_NAMEs: GUTKIND, JORGE SILVIO ;ZHANG, JIN  (contact)

PROJECT_TERMS: Aging;Biological Assay;Biology;Biosensor;cancer therapy;cell growth;Cell Nucleus;Cell Physiology;Cells;Cellular Assay;Cessation of life;Cetuximab;Chemicals;Clinical;Color;Combined Modality Therapy;Complex;Detection;Diabetes Mellitus;Disease;DNA Polymerase II;DNA Polymerase III;Drug resistance;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Event;FDA approved;FRAP1 gene;Genetic Transcription;Goals;Location;Malignant Neoplasms;Mediating;Modeling;Molecular;molecular actuator;mouth squamous cell carcinoma;multiplexed imaging;Nervous System Disorder;novel;Nuclear;Nuclear Translocation;Oncogenic;Pathway interactions;Phase II Clinical Trials;phosphoproteomics;Phosphotransferases;PIK3CG gene;Process;recruit;Regulation;Reporter;Research;Resistance;response;Reverse Transcriptase Polymerase Chain Reaction;Role;Series;Signal Pathway;Signal Transduction;Signaling Molecule;spatiotemporal;Specificity;targeted cancer therapy;Technology;Testing;tool;Toxic effect;transcriptome sequencing;tumor;tumorigenesis;Variant;Xenograft Model

PROJECT_TITLE: Signal Transduction by PI3K/mTOR

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: We will advance a new, volumetric imaging microscope (VIM) for high-resolution, 3-dimensional (3D) tomography. Speciﬁcally, we will integrate computational optics, microﬂuidics, and machine learning approaches; it will make the VIM capable of resolving a large number of individual cells in 3D culture. We will use the VIM to analyze how single cells in a tumor spheroid change their phenotypes under drug treatment.

PI_NAMEs: LEE, HAKHO  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: 3-Dimensional;Accounting;Adopted;advanced analytics;Algorithms;anti-cancer research;Antineoplastic Agents;Antitumor Drug Screening Assays;Apoptotic;Beds;Brightfield Microscopy;cancer imaging;Cells;cellular imaging;Cellularity;chemotherapy;Classification;Clinical;Code;Color;computational pipelines;Computer software;computerized data processing;Data;data acquisition;Data Set;deep learning;deep learning algorithm;design;Detection;drug development;Drug resistance;drug resistance development;Drug usage;empowerment;Environment;Epithelium;experimental study;Extracellular Matrix;feature extraction;Goals;Heterogeneity;high resolution imaging;high throughput analysis;Image;imaging platform;imaging system;improved;in vivo;Individual;Infusion procedures;innovation;Lateral;Light;Lighting;Machine Learning;Malignant Neoplasms;Mechanics;Mesenchymal;meter;Methods;Microfluidics;Microscope;microscopic imaging;Microscopy;Modeling;Molecular;Monitor;multidimensional data;Optics;Organoids;Outcome;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiological;Positioning Attribute;predicting response;Proliferating;prospective;Radiation;reconstruction;Research Personnel;Resistance;resistance mechanism;Resolution;response;Scanning;self organization;single cell analysis;Source;Specimen;Speed;spheroids;statistics;Stimulus;Structure;System;Systems Development;Techniques;temozolomide;Testing;three dimensional cell culture;tomography;tool;Training;trait;Treatment outcome;tumor;tumor heterogeneity;Visual

PROJECT_TITLE: 3D Fourier Imaging System for High Throughput Analyses of Cancer Organoids


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: STATE COLLEGE OF OPTOMETRY

PHR: The purpose of the program is to introduce optometry students to basic, translational, and clinical optometric and vision science research by participating full-time for ten weeks in a summer research project. This experience is aimed at providing a pathway for the most motivated students to continue research in the OD-MS or OD-PhD towards a career as a clinician-scientist. It will also providing the next generation of optometrists the knowledge and skillset to provide the latest and most optimal vision treatment and care to their patients.

PI_NAMEs: BLOOMFIELD, STEWART ALLEN (contact)

PROJECT_TERMS: Academic achievement;Basic Science;career;Caring;Cellular biology;Clinic;Clinical;Clinical Research;college;Computer Models;Computers;Doctor of Philosophy;Electronics;Ethics;experience;Future;Health Professional;Journals;Knowledge;Libraries;member;Mentors;Nerve Regeneration;neuroprotection;New York;Optics;Optometrist;Optometry;Patients;Pharmacology;Problem Solving;programs;Research;research faculty;Research Personnel;Research Project Grants;responsible research conduct;Schools;skills;square foot;student training;Students;Teacher Professional Development;Training;Training Programs;Translational Research;Universities;Vision;Vision research;vision science;visual neuroscience;Visual Psychophysics

PROJECT_TITLE: Short-Term Training of Students in Health Professional Schools


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Immunotherapy;Skin Cancer

ORG_CITY: IRVINE

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Narrative The goal of this proposal is to evaluate the ability of intravital multiphoton microscopy (MPM) imaging to identify and distinguish immune cell populations in human skin, based on label-free molecular contrast. We will utilize a fast, large area multiphoton exoscope (FLAME), an imaging platform recently designed and developed by our group to have unique performance features optimized for clinical skin imaging: macroscopic (mm-scale) scanning area, high speed, subcellular resolution, label-free molecular specificity. Completion of this study will establish the practical utility and value of FLAME as a non-invasive bedside imaging tool to detect early immune reactions, to understand the mechanisms initiating skin autoimmune diseases and to monitor the immune response to skin therapies.

PI_NAMEs: BALU, MIHAELA  (contact);GANESAN, ANAND K

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Address;Animal Experiments;Animal Model;Antibodies;Architecture;Area;Atopic Dermatitis;Autoimmune;Autoimmune Diseases;Autoimmune Process;Basal cell carcinoma;Binding Proteins;Biological Assay;Biological Markers;Blood Vessels;cancer therapy;Cell Communication;cell type;Cells;Cellular Metabolic Process;Cellular Morphology;Chemicals;Clinical;clinical imaging;Clinical Research;Collaborations;combinatorial;Cutaneous;density;Dermal;design;Detection;detection sensitivity;Devices;Disease;Disease remission;Early Diagnosis;Environment;Fluorescence;fluorophore;Germany;Goals;Heterogeneity;Histologic;Human;human imaging;Image;imaging approach;Imaging Device;imaging platform;Immune;immune activation;immune imaging;Immune response;Immune system;Immunologic Monitoring;immunoreaction;Immunotherapy;improved;in vivo;in vivo imaging;Inflammatory;Investigation;Knowledge;Label;Lesion;Malignant Neoplasms;Measurement;Measures;Melanins;Metabolic;Methods;Microscopic;microscopic imaging;Modeling;Molecular;Morphology;mouse model;multi-photon;multiphoton microscopy;Mus;NADH;optical imaging;Optics;Pathogenesis;Performance;Phase;Pigments;Play;Population;Remission Induction Therapy;Reporter;Reporting;Resolution;response;RNA Probes;Role;Scanning;Signal Transduction;Skin;Skin Cancer;Skin Carcinoma;skin disorder;Spatial Distribution;spatiotemporal;Specificity;Speed;Structure;success;Techniques;Technology;Three-Dimensional Image;Time;Tissues;tumor-immune system interactions;Validation;Visualization;Work

PROJECT_TITLE: In vivo label free optical imaging of immune cells in human skin

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness

ORG_CITY: CARDIFF

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: CARDIFF UNIVERSITY

ORG_ZIPCODE: CF24 0DE

PHR: Project Narrative / Relevance Now in its 13th year, the Psychiatric Genomics Consortium is perhaps the most innovative and productive experiment in the history of psychiatry. We propose to expand the work of the PGC so we can learn key lessons about the fundamental basis of major psychiatric disorders

PI_NAMEs: LEWIS, CATHRYN ;O'DONOVAN, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;Address;Affect;Alleles;base;biobank;Biological;Biology;Biotechnology;career;case control;Cells;Clinical;Collaborations;Communication;Communities;Country;Data;Diagnostic;digital media;Disease;DNA Resequencing;education resources;Educational Materials;Ensure;Epidemiology;exome;exome sequencing;experimental study;Facebook;Family;Fostering;functional genomics;Funding;Genes;Genetic;genetic architecture;genetic pedigree;Genetic Variation;Genets;Genome;genome sequencing;genome wide association study;genomic data;genomic locus;Genomics;Goals;improved;Individual;Industry;innovation;insight;Institution;instrument;Investments;Journals;Knowledge;Learning;Life;Maps;Measures;Medical;Medicine;Mendelian randomization;Mental disorders;Meta-Analysis;Methods;Mission;Modeling;Molecular;National Institute of Mental Health;Nature;Neurosciences;novel;novel therapeutics;Outcome;outreach;Paper;patient stratification;patient subsets;Patients;Phase;Phenotype;predict clinical outcome;Productivity;Psychiatric Diagnosis;psychiatric genomics;Psychiatry;rare variant;Recording of previous events;Reproducibility;Research Personnel;Resistance;Resources;Risk;Risk Factors;Science;Scientist;severe psychiatric disorder;Source;statistics;success;Symptoms;Therapeutic;therapeutic development;Time;translational potential;Twitter;Update;Variant;whole genome;Work;working group

PROJECT_TITLE: 5/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-B(02)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Disability Research;Mental Health;Neurosciences;Pain Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative. In older adults with musculoskeletal pain, both joint pathology and pain have been associated with mobility decline, but the relationship between joint pathology and pain and their unique contributions to mobility decline is more complex, because pain is shaped by a combination of central and peripheral factors. The proposed study goes beyond the characterization of an individual mechanism and integrates multiple fields of study using a biopsychosocial approach to identify the factors that contribute to functional trajectories of mobility decline in aging.

PI_NAMEs: COOMBES, STEPHEN ;CRUZ-ALMEIDA, YENISEL  (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Accounting;Address;Affective;Age;age related;aged;Aging;Anxiety;Behavioral;biopsychosocial;Body mass index;Brain;chronic musculoskeletal pain;Clinical;Communities;Complex;Corticospinal Tracts;Data;density;Diffusion Magnetic Resonance Imaging;disability impact;Disinhibition;Elderly;Electroencephalography;Ethnic Origin;experience;field study;Frequencies;Gait speed;Individual;Joints;Knowledge;life span;Link;Longitudinal Studies;Measures;Mediating;Mental Depression;Mobility decline;Mobility disability;Musculoskeletal Pain;neural;Neurobiology;neuroimaging;novel;older adult;Older Population;Pain;Pain Measurement;Pathology;Patient Self-Report;Peripheral;Pharmaceutical Preparations;Positioning Attribute;Predictive Factor;preservation;Process;prospective;Prospective Studies;psychosocial;Publishing;Quality of life;Race;recruit;Research;Research Design;Role;sex;Shapes;Site;social;Socioeconomic Factors;standardize measure;Structure;Testing;Time;Tissues;Visit;Walking;Water;Work

PROJECT_TITLE: Biopsychosocial pain predictors of mobility decline in aging


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Acute lung injury (ALI) and its more severe form referred to as acute respiratory distress syndrome (ARDS) are common severe complications of an influenza infection. This complication is a result of the immune system becoming hyper-active and attacking the lung. The research in this proposal will help us understand why in some patients the immune system becomes too active and how one can present severe complications of an influenza infection by targeting the excessive immune response.

PI_NAMEs: ZHANG, LIANGHUI  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Acute respiratory failure;allograft rejection;Antigen Presentation;Antigen-Presenting Cells;Antigens;Blood Vessels;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death;cell injury;cell regeneration;Cessation of life;Complication;cytotoxic CD8 T cells;Data;Death Rate;Development;Developmental Gene;Endothelial Cells;endothelial regeneration;Endothelium;epithelial injury;Equilibrium;Granzyme;Heterogeneity;Histocompatibility Antigens Class II;Homeostasis;Hospitalization;Hyperactivity;I-antigen;Immune;Immune response;Immune system;immunoregulation;In Vitro;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammatory;Influenza;Influenza A Virus, H1N1 Subtype;influenza epidemic;influenza infection;influenzavirus;injured;Injury;insight;Lung;lung injury;lung vascular injury;Major Histocompatibility Complex;Mechanical ventilation;Mediator;mortality;mouse model;Natural regeneration;neutralizing antibody;new therapeutic target;novel;overexpression;Parasitic infection;Pathogenicity;Pathway interactions;Patients;Play;Poly I-C;prevent;Process;Pulmonary Edema;regenerative;Regulator Genes;Research;Role;seasonal influenza;Secondary to;Severities;Signal Transduction;single-cell RNA sequencing;SOX17 gene;T cell therapy;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;transcription factor;Vascular Endothelial Cell;Viral;viral RNA;Virulence Factors;Virus;Work

PROJECT_TITLE: Endothelial antigen presentation to T cells as a pathogenic mechanism in influenza-induced acute lung injury

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: DAVIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Over 90% of the cells in the human body are microbes, the majority of which reside in the large intestine, where they provide benefit to the host by providing niche protection against colonization with potentially harmful bacteria, a property known as colonization resistance. Antibiotic therapy is accompanied by a microbial imbalance that leads to a loss of colonization resistance. Here we will study the underlying mechanism by which antibiotic treatment increases susceptibility to potentially harmful bacteria and approaches to restore colonization resistance, which will usher in important conceptual advances that have a strong potential to exert a high impact on this field of science.

PI_NAMEs: BAUMLER, ANDREAS J (contact);TSOLIS, RENEE M

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: antibiotic resistant infections;Antibiotic Therapy;Antibiotics;Bacteria;Biology;Butyrates;carbapenem-resistant Enterobacteriaceae;Carbon Dioxide;Cells;colonization resistance;Data;Development;drug development;Drug Targeting;dysbiosis;Engraftment;Enterobacteriaceae;Epithelium;Equilibrium;expectation;experimental study;Fiber;Funding;Goals;Growth;gut microbiota;Habitats;host microbiota;Human body;Hypoxia;immune function;Immunocompromised Host;Impairment;infection risk;innovation;insight;interest;Intestines;Large Intestine;Mediating;member;Metabolism;Microbe;microbial;microbial community;microbiome;microbiota;microbiota metabolites;microorganism;Modeling;Modification;new therapeutic target;non-typhoidal Salmonella;novel;novel strategies;Outcome;pathogen;Pathogenesis;Pathogenicity;Predisposition;preservation;prevent;Production;Property;public health relevance;Research;Research Personnel;Resistance;Resources;Salicylic Acids;Science;Sepsis;Shapes;Signal Pathway;Source;Surface;Testing;Therapeutic Intervention;Time;trait;Volatile Fatty Acids;Work

PROJECT_TITLE: Mechanism of Colonization Resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Y(02)M]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: BATON ROUGE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project narrative Overall The Center for Pre-Clinical Cancer Research (Cancer COBRE) aims to identify clinically relevant mechanisms of human cancer disease using models that closely reflect the disease state in the context of the tumor microenvironment. The four PJI projects feature osteosarcoma, breast cancer, liver cancer, and prostate cancer as diseases that would benefit from pre-clinical models that are more predictive of mechanistic efficacy in humans. All of the PJI projects will use specialized in vivo cancer mouse models and/or in vitro 3D spheroids to identify relevant mechanisms of tumorigenesis or for evaluation of novel therapeutic strategies. The Center will promote a unified and coordinated approach by establishing new specialized core facilities 1) Pre-Clinical Evaluation Core (PCEC) to provide scientific expertise and technical support for the pre-clinical evaluation and Molecular Biology and Immunopatholgy Core (MBIPC) to provide access to state-of-the-art equipment and expertise in Molecular Biology and Immunopathology for the PJI projects.

PI_NAMEs: FRANCIS, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: 3-Dimensional;Address;Affect;African American population;Animal Diseases;Animal Model;anti-cancer research;Antineoplastic Agents;Award;Biomedical Research;Cancer Model;Cell Culture System;Centers of Research Excellence;Clinical Trials;clinically relevant;Communities;Complement;Core Facility;Culture Techniques;Development;Disease;disease model;disease phenotype;Doctor of Philosophy;Equipment;Evaluation;Exhibits;experience;Extramural Activities;Funding;Goals;health disparity;Heterogeneity;Historically Black Colleges and Universities;Human;human disease;immunopathology;In Vitro;in vivo;in vivo Model;Individual;Infectious Diseases Research;Infrastructure;insight;Institution;Louisiana;Lung;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of prostate;Malignant Neoplasms;Mentored Research Scientist Development Award;Mentorship;Mission;Modeling;Molecular Biology;mortality;mouse model;Mus;NCI Center for Cancer Research;neoplastic cell;novel therapeutic intervention;novel therapeutics;Osteosarcoma;Outcome;Patients;Phase;Phenotype;pre-clinical;Pre-Clinical Model;preclinical evaluation;programs;Research;Research Personnel;Research Project Grants;Resources;Role;spheroids;success;System;Technology;Therapeutic;therapy outcome;three dimensional cell culture;three-dimensional modeling;Training;translational approach;translational therapeutics;tumor;tumor microenvironment;tumor progression;tumorigenesis;United States National Institutes of Health;Universities;Veterinary Medicine;Veterinary Schools

PROJECT_TITLE: Center for Pre-Clinical Cancer Research


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer

PROJECT_TERMS: Accounting;Achievement;Advanced Malignant Neoplasm;Advisory Committees;anti-cancer research;biomedical scientist;Cancer Model;career;career development;Centers of Research Excellence;Collaborations;Communities;Data;Dedications;Disease;disease model;Doctor of Philosophy;Educational workshop;Effectiveness;Ensure;Environment;Evaluation;experience;Faculty;Feedback;Fostering;Funding;Future;Goals;graduate student;Grant;Human;immunopathology;Infrastructure;International;Louisiana;Malignant Neoplasms;Measures;Medical;meetings;Mentors;Modeling;Molecular;Molecular Biology;novel therapeutic intervention;Office of Administrative Management;Patients;Phase;Pilot Projects;Play;Postdoctoral Fellow;pre-clinical;Pre-Clinical Model;preclinical evaluation;preclinical study;predictive modeling;programs;Records;Research;research facility;Research Personnel;Research Training;Resources;Role;Science;Scientific Advances and Accomplishments;Scientist;Senior Scientist;Students;success;Technology;therapy outcome;Training;Training Activity;Training and Education;Treatment outcome;tumor progression;tumorigenesis;Universities;Veterinarians;Veterinary Medicine;Veterinary Schools;Walking;web site;Writing

PROJECT_TITLE: Administration Core


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: This research will provide needed information on the clinical course and outcomes for persons with HIV (PWH) engaged in HIV care. Due to national efforts, the majority of PWH are care and improved treatments promise a multi-decade lifespan. We will provide data on how substance use impacts this lifespan, particularly on the occurrence of non-AIDS comorbidity, survival and the outcomes of viral hepatitis. We have, and will continue to collaborate with others in this effort.

PI_NAMEs: MOORE, RICHARD DOUGLAS (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;African American;Age;Aging;antiretroviral therapy;Baltimore;Behavioral;Cardiovascular system;care delivery;Caring;Catchment Area;Chronic;Cirrhosis;Clinical;clinical care;Clinical Course of Disease;Clinical Research;Clinical Sciences;Clinical Trials;co-infection;Cocaine;cocaine use;cohort;Collaborations;comorbidity;Continuity of Patient Care;Data;Diagnosis;Disease;Drug usage;effective therapy;Epidemic;Epidemiology;Fibrosis;follow-up;Funding;Future;Geography;Goals;Growth;Hepatitis C;Hepatitis C co-infection;Hepatitis C Therapy;heroin use;HIV;HIV Infections;HIV/AIDS;implementation science;improved;Incidence;Infection;Kidney;Life;Life Expectancy;life span;Liver;Liver diseases;Liver Fibrosis;Malignant neoplasm of liver;Manuscripts;Maryland;Measurement;Measures;Mental Health;Metabolic;Morbidity - disease rate;mortality;multiple chronic conditions;National Institute of Drug Abuse;neoplastic;Neurocognitive Deficit;Observational Study;Opioid;Outcome;Overdose;Participant;Pathogenesis;patient population;Patients;Peer Review;Persons;Population;Prevalence;Primary carcinoma of the liver cells;Productivity;prognostic;Publications;Publishing;Recording of previous events;Research;Research Personnel;Resources;Risk;Risk Factors;Site;Socioeconomic Factors;socioeconomics;Standardization;substance use;substance use treatment;Suicide;therapy adherence;Time trend;translational study;transmission process;Traumatic injury;treatment and outcome;Treatment Factor;Viral;Viral hepatitis;Woman

PROJECT_TITLE: Johns Hopkins HIV Clinical Cohort


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hematology;Liver Disease;Neurosciences

ORG_CITY: HERSHEY

ORG_DEPT: NEUROLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE  Chronic exposure to manganese (Mn) is associated with motor and neurobehavioral deficits. This project proposes to examine how a gene variant carried by one-fifth of the U.S. population affects the relationships between Mn exposure, brain Mn accumulation, and motor and neurobehavioral outcomes.

PI_NAMEs: WANG, ERNEST W (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Address;Affect;Age;Aspartate;Brain;Brain Mapping;Brain region;caudate nucleus;Cell Physiology;Chemicals;Child;Chronic;cofactor;cohort;Cohort Studies;Complex;Data;Data Analyses;Development;Dose;Exposure to;extracellular;Fellowship;genetic regulatory protein;genetic variant;Guidelines;Hemochromatosis;Histidine;Human;Image;image processing;Individual;interest;Iron;loss of function;Magnetic Resonance Imaging;Manganese;Mediating;metal transporting protein 1;Modeling;Motor;multidimensional data;neurobehavior;neurobehavioral;neurotoxic;neurotoxicity;neurotoxicology;Occupational Exposure;Outcome;Physicians;Population;Population Study;Positioning Attribute;Proteins;public health relevance;receptor mediated endocytosis;recruit;Relaxation;response;Role;Safety;Scientist;Statistical Data Interpretation;Structure;Testing;TFRC gene;Time;Training;Welding

PROJECT_TITLE: Effects of HFE H63D on Brain Mn Accumulation and Neurotoxicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-Z(20)]


NIH_SPENDING_CATS: Autoimmune Disease;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Inflammation contributes to many diseases including autoimmunity and acute liver injury. These diseases involve unique forms of inflammation regulated by RIPK1, which can promote or inhibit inflammation in a context and cell type specific manner. The goal of this proposal is to determine how RIPK1 kinase mediates inflammation that drives human disease.

PI_NAMEs: KELLIHER, MICHELLE ALICE (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Acute;acute liver injury;AGFG1 gene;Anti-Inflammatory Agents;Apical;Apoptosis;Autoantibodies;Autoimmune;Autoimmune Hepatitis;Autoimmunity;autoinflammatory;Binding;Bone Marrow;Cell Cycle;Cell Death;Cell Death Signaling Process;Cell membrane;Cell Membrane Permeability;cell type;Cells;Chimera organism;chronic inflammatory disease;Complex;Concanavalin A;cytokine;Cytoprotection;Data;Dendritic Cells;Development;Disease;disease model;DNA;Genetic;Genetic study;Goals;Hematopoietic;Hepatocyte;Homeostasis;human disease;Immune;Immune signaling;Immune system;Immune System Diseases;immunogenic;Immunologic Receptors;immunoreaction;improved;Incidence;Infection;Inflammation;Inflammatory;inhibitor;Injury;innate immune sensing;innovation;Interferons;kinase inhibitor;Knockout Mice;Ligation;Liver;liver inflammation;liver injury;Lupus;Mediating;Modeling;Molecular;mouse genetics;mouse model;Mus;NF-kappa B;novel;Nucleic Acid Binding;Nucleic Acids;Outcome;Pathway interactions;Patients;Pattern;Phosphorylation;Phosphotransferases;Plant Lectins;prevent;Protein Deficiency;Protein Kinase Interaction;Receptor-Interacting Protein;reconstitution;Research;restraint;RIPK3 gene;RNA;Role;scaffold;sensor;Signal Transduction;Stimulator of Interferon Genes;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;tissue injury;Tissues;TNF gene;Toll-like receptors;Tumor Necrosis Factor Receptor;Viral;Viral hepatitis;Work;Workplace;Z-DNA Binding Protein;Z-Form DNA

PROJECT_TITLE: Rip Proteins in Innate Immune Signaling

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Precision Medicine

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: The Cox regression is the important method for assessing the effects of different factors on the time-to-event outcomes. The project will propose novel approaches to improve the Cox regression estimation. The computing tools based on the proposed methods will improve the scientific rigor and the reporting of findings for clinical studies with time-to-event outcomes.

PI_NAMEs: HALABI, SUSAN ;WU, YUAN  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Algorithms;Area;Biological;Cancer Patient;Characteristics;Chi-Square Distribution;Clinical Research;Clinical Treatment;Clinical Trials;Cox Models;Cox Proportional Hazards Models;Data;design;Detection;Development;Disease;Event;exceptional responders;experience;hazard;Immunotherapy;immunotherapy trials;improved;Individual;interest;Investigation;Libraries;Malignant Neoplasms;Maximum Likelihood Estimate;Methods;Molecular;novel;novel strategies;Observational Study;Outcome;Patients;Pattern;Performance;phase 2 study;Phase II/III Trial;phase III trial;precision medicine;primary endpoint;primary outcome;Probability;Progression-Free Survivals;Randomized;Reporting;Research;Residual state;Sampling Studies;semiparametric;simulation;statistics;Survival Analysis;Test Result;Testing;Time;tool;treatment effect;Treatment Efficacy

PROJECT_TITLE: Sieve based full likelihood approach for the Cox proportional hazards model with applications to immunotherapies trials


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Orphan Drug;Prostate Cancer;Rare Diseases;Urologic Diseases

PI_NAMEs: LOPEZ, MANDI J. (contact)

PROJECT_TERMS: 3-Dimensional;3D Print;Address;Animal Cancer Model;Animal Diseases;Animal Model;anti-cancer research;Antineoplastic Agents;Apoptosis;Biological;Biological Assay;Biology;bioprinting;cancer cell;Cancer Model;Cell Culture System;Cell Culture Techniques;Cell Proliferation;Cell Separation;Cells;Centers of Research Excellence;Chronic;clinically relevant;Complement;Consult;Consultations;Core Facility;CRISPR/Cas technology;Data Analyses;Development;Disease;Drug Kinetics;Drug Screening;Emerging Technologies;Equipment;Evaluation;Exhibits;experience;Experimental Designs;Extracellular Matrix;Faculty;Gene Expression;genetic manipulation;Goals;graduate student;Human;Human Cell Line;human disease;human model;Image;Immunohistochemistry;Immunologics;In Vitro;in vivo;in vivo Model;insight;instrumentation;Lung;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Modeling;Molecular Biology;mouse model;Mus;Mutagenesis;novel therapeutic intervention;novel therapeutics;Osteosarcoma;Outcome;Pathology;Patient-Focused Outcomes;Patients;Pharmacotherapy;Population;Postdoctoral Fellow;pre-clinical;Pre-Clinical Model;preclinical evaluation;Progressive Disease;Reagent;Regenerative Medicine;Research;Research Personnel;Resource Development;Resources;scaffold;screening;Services;Signal Pathway;spheroids;Structure;System;Technology;Therapeutic;three dimensional cell culture;Toxic effect;Toxicology;Training;Training and Education;translational cancer research;Translational Research;translational therapeutics;tumor;tumor microenvironment;tumorigenesis;Update;Validation

PROJECT_TITLE: Pre-Clinical Evaluation Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Mental Health;Neurodegenerative

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Delirium is a serious, yet understudied, cognitive disorder that affects millions of elder Americans, and is closely related to Alzheimer’s disease and related dementias (ADRD). The NIA-supported (2015-2020) Network for Investigation of Delirium Unifying Scientists (NIDUS), a collaborative international network of delirium investigators, developed a successful, annual “NIDUS Bootcamp” conference, laying the foundation for this proposal. The new Delirium Bootcamp (DBC) will convene junior investigators and senior faculty in an annual conference with innovations including: 1) a new thematic focus each year, with the 2021 theme highlighting ADRD; 2) focus on high-impact, state-of-the-art methodologies to advance the field in new directions; 3) finding optimal methods to address the unique challenges of delirium research, and 4) developing collaborative interdisciplinary papers to be initiated at the DBC and completed in ongoing groups; thus, fostering the training, career development and success of the next generation of delirium investigators.

PI_NAMEs: BUSBY-WHITEHEAD, JAN  (contact);DEVLIN, JOHN W.

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acceleration;Acute;Acute Disease;Address;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;American;Animal Model;Area;Attention;Award;Bibliography;Big Data;Caliber;career;career development;Clinical;clinical practice;Cognition;Cognition Disorders;Collaborations;Communities;Community Networks;Complex;Complication;cost;COVID-19;COVID-19 complications;Delirium;Discipline;Education;Elderly;Epidemiology;Faculty;Feedback;Fostering;Foundations;Funding;Future;Goals;Grant;Health Expenditures;improved;Infrastructure;innovation;Institution;interdisciplinary collaboration;International;Investigation;Knowledge;Laboratories;lectures;Machine Learning;Measurement;meetings;Mentors;Mentorship;Methodology;Methods;multidisciplinary;National Institute on Aging;neglect;Network Infrastructure;next generation;older adult;Operative Surgical Procedures;Paper;Participant;patient population;peer;Peer Review;Pilot Projects;programs;Public Health;Publications;Publishing;R24;randomized trial;Reporting;Research;Research Methodology;Research Personnel;Resources;response;SARS-CoV-2 infection;Science;Scientific Advances and Accomplishments;Scientist;secondary analysis;senior faculty;Series;skill acquisition;Societies;Study Section;success;support network;symposium;systematic review;Training;United States National Institutes of Health;webinar;working group;Writing

PROJECT_TITLE: The Network for Investigation of Delirium: Unifying Scientists (NIDUS)'s 9th-13th Annual Delirium Boot Camps: A Foundation for Future Exploration

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Women's Health Research

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: Project Narrative One in eight women will develop breast cancer over the course of her lifetime, and half of those women will succumb to the disease. Genetic predispositions, like mutations in the BRCA1 gene, increase the risk of developing breast cancer by over 50%, but it is largely unclear what determines whether cancer will in fact develop in a particular patient. Our previous work identified a role for epigenetic alterations in modulating to breast cancer, and we now aim to determine how alterations to the epigenome affect the development of Brca1-deficient mammary tumors, a strategy that will help to identify molecular pathways as potential strategies to block development of BRCA1-deficient breast cancer.

PI_NAMEs: DOS SANTOS, CAMILA  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Affect;Age;BRCA1 gene;BRCA1 Mutation;Breast;Breast Cancer Cell;Breast Cancer Prevention;breast cancer progression;Breast Cancer Risk Factor;Breast Epithelial Cells;Bromodomain;c-myc Genes;cancer risk;cancer subtypes;Cancer-Predisposing Gene;Cell Differentiation process;Cells;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;clinically relevant;Communities;Dependence;Development;Disease;Disease Resistance;Disease susceptibility;DNA Sequence Alteration;Down-Regulation;Epigenetic Process;epigenome;epigenomics;Genetic;Genetic Predisposition to Disease;Genetic Transcription;Goals;high risk;Human;Individual;Inherited;innovation;Knowledge;Link;loss of function;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Mammary Neoplasms;Mammary Tumorigenesis;Modeling;Modification;Molecular;Mus;mutant;Mutation;Nucleic Acid Regulatory Sequences;NURF;Oncogenes;Organoids;Outcome;overexpression;Pathway interactions;Patients;PHD Finger;Play;post pregnancy;pre-clinical;Predisposition;Pregnancy;prevent;Primary Prevention;Prognostic Marker;programs;Proteins;Reader;Regulation;Relapse;Repression;response;Risk;Risk Factors;Role;small molecule;targeted treatment;Tertiary Protein Structure;therapy resistant;tool;transcription factor;tumor;tumor progression;tumorigenesis;Woman;Work

PROJECT_TITLE: Probing the role of epigenomics in Brca1-deficient mammary tumors.

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative Structural racism– the totality of ways by which society fosters racial discrimination through mutually reinforcing inequitable systems in housing, education, employment, health care, criminal justice and other domains-- affects minority groups in the U.S. disproportionately, including Black women. The present proposal will assess whether and how various forms of structural racism influence the incidence of Alzheimer’s Disease and Related Dementias in Black women.

PI_NAMEs: ROSENBERG, LYNN  (contact)

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Acceleration;Address;Affect;Age;Age of Onset;Alcohol consumption;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Attention;Biological Factors;Black American;black women;caucasian American;Censuses;Characteristics;Chronic;Chronic stress;cohort;combat;comorbidity;Complex;County;Criminal Justice;Data;Data Collection;data resource;Data Sources;deprivation;Development;Diabetes Mellitus;Dietary intake;Disparity;Education;Educational Status;Employment;Enrollment;Environmental Exposure;Exercise;experience;Follow-Up Studies;Fostering;Funding;Geographic Locations;Geography;Health;Health Disparities Research;Health Food;Healthcare;high risk population;Housing;human old age (65+);Hypertension;Imprisonment;Incidence;indexing;Individual;Inequity;Investigation;Justice;Life;Life Cycle Stages;Link;Measurement;Measures;Mediating;Mediation;Medicare;Methods;Minority Groups;National Institute on Aging;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesogenic;Outcome;Participant;Pathway interactions;Pattern;Physical activity;Physical environment;policy recommendation;Poverty;protective factors;Publishing;Questionnaires;racial discrimination;racism;Recording of previous events;Records;Recreation;Reporting;Research;Resources;Risk;Risk Factors;Schools;Smoking;social;social epidemiology;Social support;Societies;Structural Racism;System;Testing;Time;Unemployment;Voting;Weight Gain;Women's Health;Work

PROJECT_TITLE: The Influence of Structural Racism on Incidence of Alzheimer's Disease and Related Dementias (ADRD) in Black women