NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Immunotherapy;Machine Learning and Artificial Intelligence;Neurosciences;Rare Diseases

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Our inability to explain why some patients do not respond to immunotherapy, combined with our inability to predict the responders, poses a serious challenge to advancing cancer care and research. Currently, biopsies serve as the most informative way to assess the immunological activity within a cancerous area, but we are spatially and temporally limited in the number of biopsies we can obtain from patients, especially in cases of brain cancer. We propose here a novel strategy merging artificial intelligence and mechanistic modeling to reveal the spatial and temporal tumor-immune landscape within patients by connecting a unique resource of image-localized biopsies and clinical imaging for cohorts treated with standard and immunotherapies.

PI_NAMEs: CANOLL, PETER ;HU, LELAND ;SWANSON, KRISTIN R (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Advanced Malignant Neoplasm;anti-cancer research;Anti-Inflammatory Agents;Area;Artificial Intelligence;Biological;biological heterogeneity;Biophysics;Biopsy;cancer care;Cancerous;cell type;Cells;Classification;Clinical;clinical decision-making;clinical imaging;cohort;Complex;Computer Models;cytotoxic;Data;Decision Making;Diagnostic;Early identification;Edema;effective therapy;Environment;Evolution;Future;Glioblastoma;Glioma;Goals;Heterogeneity;Image;Immune;immune cell infiltrate;Immune system;Immunologics;Immunology;Immunosuppression;Immunotherapy;In Situ;in vivo;Inflammation;Inflammatory;insight;Link;Location;Machine Learning;machine learning model;Macrophage;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Measures;Microglia;Modeling;Molecular;molecular phenotype;neoplastic cell;Neuroglia;novel strategies;Oncology;Operative Surgical Procedures;Outcome;outcome prediction;Pathway interactions;Patient-Focused Outcomes;Patients;personalized approach;Phenotype;Physics;Population;predictive modeling;Predisposition;Prognosis;quantitative imaging;radiomics;Recurrence;Resources;response;Role;Scientist;serial imaging;sex;Sex Differences;Signal Transduction;single-cell RNA sequencing;Spatial Distribution;spatiotemporal;Specimen;standard of care;synergism;System;Testing;Therapeutic;Therapeutic Intervention;Time;tool;tumor;tumor behavior;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;tumor-immune system interactions;Variant

PROJECT_TITLE: Image-based models of tumor-immune dynamics in glioblastoma


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Regenerative Medicine

ORG_CITY: BERKELEY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The growth of tissues and organs is regulated such that they stop growing when they reach the correct size and shape. In some instances damaged organs can grow back (regenerate) completely while in other cases they cannot. Our research, which aims to understand growth, will provide insights into diseases such as cancer and birth defects, which are characterized by growth abnormalities, and will also suggest ways to improve regeneration.

PI_NAMEs: HARIHARAN, ISWAR K. (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adult;Anterior;Atlases;Back;blastema;Cell Proliferation;Cell Shape;Cell Surface Proteins;Cell Survival;Cells;Congenital Abnormality;Development;Disease;Distant;Drosophila genus;Experimental Genetics;gene function;gene regulatory network;Genes;Genetic;Genetic Screening;Goals;Growth;Heterogeneity;imaginal disc;improved;in vivo;Individual;insight;Ion Channel;Ligands;Malignant Neoplasms;Membrane Potentials;Natural regeneration;Organ;Pattern;Piezo ion channels;planar cell polarity;Proliferating;Property;receptor;regenerative growth;Regulation;Research;Role;Shapes;smoothened signaling pathway;Structure;tool;transcriptomics;Wing;Work

PROJECT_TITLE: Genetic Regulation of Developmental and Regenerative Growth

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Clinical Research;Emergency Care;Lung;Physical Injury - Accidents and Adverse Effects;Prevention;Rare Diseases

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE Trauma-induced acute respiratory distress syndrome (ARDS) typically results as an indirect consequence of a severe physical trauma or infection. Once ARDS develops, it is particularly difficult to reverse, making it imperative to identify trauma patients at risk of developing ARDS and to administer preventative treatments before the onset of ARDS. Our overarching goal is to develop and commercialize a diagnostic tool that is capable of quantitatively and rapidly assessing the risk of trauma-induced ARDS at the point of care.

PI_NAMEs: WHITE, IAN M (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Accident and Emergency department;Acute;Acute Respiratory Distress Syndrome;Admission activity;Alkanes;Anti-Inflammatory Agents;Antibodies;Automation;Benchmarking;Binding;Biological Assay;Blood;Blood capillaries;Blood specimen;Blood Vessels;Body part;Cell Death;Cells;Circulation;Clinical;commercialization;Cytolysis;Data;Death Rate;design;Detection;Diagnostic;diagnostic technologies;diagnostic tool;DNA;Early Diagnosis;Edema;Environment;Enzyme-Linked Immunosorbent Assay;Fingers;Freeze Drying;Goals;Hemorrhage;Heparin;Histones;Immune;improved;Incidence;Infection;Inflammatory Response;Injury;innovation;instrument;Intellectual Property;invention;Investments;Label;Life;Link;Lung;lung failure;lung injury;Manuals;Measurement;Measures;meetings;Morbidity - disease rate;mortality;neutrophil;Operating Rooms;Optics;Organ;Outcome;Patient risk;Patients;Performance;Phase;point of care;point of injury;Point-of-Care Systems;portability;preservation;prevent;Preventive treatment;prototype;Reagent;Refrigeration;Reporting;Research;Respiration Disorders;Risk;Risk Assessment;sample collection;Sampling;Secure;Shock;Syndrome;System;Technology;Temperature;Thrombosis;Trauma;trauma centers;Trauma patient;Traumatic injury;Tube;Vacuum;Validation;Venous;Whole Blood

PROJECT_TITLE: Point-of-care system to assess the risk of trauma-induced acute respiratory distress syndrome


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Breast Cancer;Cancer;Colorectal Cancer;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative There has been an extraordinary growth in recent years of new techniques to predict common diseases using a new genetic intervention, polygenic risk scores (PRS). The Rational Integration of Polygenic Risk Scores (RIPS) project will use economic modeling to project the lifetime clinical impact and cost-effectiveness of screening a diverse population with PRS to predict the onset of heart disease, breast cancer, and colorectal cancer. The models produced by this study will account for the cost of genetic testing, the cost and effectiveness of the preventative care needed to reduce risk, and the potential pitfalls associated with using these novel interventions in underrepresented and underserved populations.

PI_NAMEs: HAO, JING ;PETERSON, JOSEPH F. (contact);VEENSTRA, DAVID L

PROGRAM_OFFICER_NAME: CHANG, CHRISTINE Q

PROJECT_TERMS: Address;Adopted;Affect;Age;Algorithms;Area;Atherosclerosis;Caring;Clinical;clinical outcome assessment;clinical risk;Colorectal Cancer;Complex;cost;cost effective;cost effectiveness;Costs and Benefits;Data;Data Analyses;Decision Modeling;Development;Disease;disorder risk;Disparity;economic impact;Economic Models;economic value;Effectiveness;Environment;Epidemiology;Equity;Foundations;Funding;gene therapy;genetic testing;Genomic medicine;Genomics;Growth;Health;Heart Diseases;Hereditary Breast and Ovarian Cancer Syndrome;Hereditary Nonpolyposis Colorectal Neoplasms;high risk;Hyperlipidemia;improved;Intervention;Investments;Malignant Breast Neoplasm;Mendelian disorder;Modeling;new technology;novel;Outcome;Patient Care;Patient-Focused Outcomes;Performance;polygenic risk score;Population;Population Heterogeneity;precision medicine;Prevalence;Preventive care;Preventive measure;programs;Publishing;Research;Research Priority;Review Literature;Risk;Risk Assessment;Risk Reduction;screening;Techniques;Testing;Uncertainty;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Work


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE Tumor relapse is a major clinical challenge for patients with rhabdomyosarcoma. The goal of this interdisciplinary proposal is to combine single-cell omics profiling, computational, statistical and experimental approaches to identify immature subpopulations in rhabdomyosarcoma samples, to investigate the effect of chemotherapy on selection for immature cells and to establish predictive promoter/enhancer activity markers of immature cells for analyzing clinical samples.

PI_NAMEs: CHEN, XIANG  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: activity marker;Adult;Aftercare;anti-cancer research;Archives;Bar Codes;Bayesian Analysis;biomarker development;Biopsy;Biopsy Specimen;Cell Cycle;Cell Nucleus;Cell Survival;Cells;Characteristics;chemotherapy;Child;Childhood;Childhood Rhabdomyosarcoma;Childhood Solid Neoplasm;Chromatin;Clinical;Collaborations;Computer Analysis;computerized tools;convolutional neural network;Data;data mining;deep learning;Development;Diagnosis;Disease remission;disorder risk;DNA Methylation;Enhancers;Epigenetic Process;epigenomics;Evaluation;Ewings sarcoma;experience;Formalin;Freezing;Gene Expression;Genes;Genetic Transcription;Genomics;Glioma;Goals;Government;Hematologic Neoplasms;Heterogeneity;improved;improved outcome;in vivo;in vivo Model;Individual;innovation;leukemia;Machine Learning;machine learning algorithm;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mesoderm Cell;Methods;methylation pattern;methylome;Modeling;Molecular;Monitor;Morphology;multidisciplinary;Muscle Cells;Myoblasts;myogenesis;neoplastic cell;Network-based;Normal Cell;novel;Orthoptics;Outcome;Paraffin Embedding;Paraxial Mesoderm;Pathway interactions;patient derived xenograft model;Patients;Persons;Pilot Projects;Population;Positioning Attribute;preservation;Productivity;prognostic significance;promoter;prototype;Rare Diseases;reconstitution;Recurrence;Recurrent disease;Recurrent tumor;Relapse;Research;Research Proposals;Resistance;response;Rhabdomyosarcoma;Risk;Risk Factors;Risk Reduction;Role;Saint Jude Children's Research Hospital;Sampling;single cell ATAC-seq;single nucleus RNA-sequencing;single-cell RNA sequencing;Skeletal Muscle;soft tissue;Solid;Specimen;Testing;therapy resistant;Tissue-Specific Gene Expression;transcriptome sequencing;transcriptomics;Translational Research;tumor;tumor DNA;tumor heterogeneity

PROJECT_TITLE: The Role of Immature Tumor Subpopulations In Pediatric Rhabdomyosarcoma

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Services;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Cancer treatment providers – whether or not they are aware – encounter adult survivors of sexual violence in the course of their practice, and yet few providers have the training needed to meet the unique treatment needs of this group. The goal of the proposed R25E is to implement a blended learning program (E-Learning plus Live Workshop) to train cancer care providers in research-based, sensitive practice techniques to help reduce distress, increase feelings of safety and empowerment, and reduce triggering and retraumatization in survivors of sexual violence undergoing cancer screening and treatment. Through this training, we hope to improve the sensitivity of the cancer care offered to sexual violence survivors across the nation.

PI_NAMEs: SCHNUR, JULIE B. (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Adoption;Adult;Ally;American College of Obstetricians and Gynecologists;anxious;authority;Awareness;cancer care;Cancer Patient;cancer therapy;care providers;Caring;Clinical;Clinical Competence;cohort;Communication;Competence;Country;Course Content;Discipline;Discipline of Nursing;Disclosure;Dissociation;Distress;E-learning;Education;Educational process of instructing;Educational workshop;effectiveness evaluation;empowerment;Ensure;Evaluation;evidence base;experience;Faculty;Feeling;Future;Gender;Goals;Guidelines;healing;Health;health care quality;Health Personnel;Healthcare;Healthcare promotion;improved;indexing;Individual;individualized medicine;Knowledge;Learning;lectures;Link;Malignant Neoplasms;Medical;men;Methods;Mission;Modeling;multidisciplinary;mutual learning;online resource;Patient Self-Report;Patients;Performance;Physical therapy;Play;Practice Guidelines;preference;Prevalence;Procedures;Professional Organizations;Program Development;Program Evaluation;programs;Provider;Psychology;psychosocial;Radiation Oncology;Radiation therapy;Reaction;Recording of previous events;recruit;Reporting;Research;research clinical testing;response;Role;Safety;Sampling;satisfaction;Screening for cancer;Self Efficacy;sexual violence;skill acquisition;skills;statistics;Surveys;Survivors;symposium;Techniques;Time;Touch sensation;Training;Training Activity;Training Programs;transfer learning;United States;United States Department of Veterans Affairs;Woman;Work

PROJECT_TITLE: Training Cancer Care Providers to Implement Sensitive Practice Guidelines When Treating Adult Survivors of Sexual Violence: A Blended Learning Approach

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Sleep Research

ORG_CITY: Chicago

ORG_DEPT: BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative There is an urgent need to better understand the interactions between sleep and, circadian function and dysfunction and their implications for human health including cardiometabolic health. Progress in this area is crucial for the development and implementation of preventive and therapeutic strategies to address the epidemics of chronic disease that represent a major threat to public health in America and elsewhere; if funded, the results from the research carried out by the Trainees and their preceptors will become public information. The proposed Training Program in Circadian and Sleep Research is uniquely poised to offer the multidisciplinary training needed to prepare investigators in basic, translational and patient-oriented research to lead efforts to improve our understanding of the roles of sleep and circadian function (and dysfunction) for health and disease, and to develop interventions to prevent the development, or reduce the severity and co- morbidities, of some of some of the most prevalent major chronic diseases of modern times.

PI_NAMEs: TUREK, FRED W (contact);ZEE, PHYLLIS C.

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: circadian;Grant;Research;Sleep;Training

PROJECT_TITLE: Training Grant in Circadian and Sleep Research

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Successful treatment of acute myeloid leukemia (AML) using targeted agents has been impeded by both disease heterogeneity and drug resistance. To address this challenge, we will identify unique, targetable differences in pathways activated by inflammatory cytokines in AML cells but not in healthy cells, and we will identify the mechanisms by which these pathways selectively drive the course of disease in AML patients. This study will improve our understanding of AML biology and aid in the design of new treatment strategies that effectively target AML cells and suppress disease progression while minimizing side effects by sparing healthy cells.

PI_NAMEs: AGARWAL, ANUPRIYA  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Automobile Driving;Biochemical;Biological Assay;Biology;Bone Marrow;Bone Marrow Transplantation;cancer cell;Cell Cycle Progression;cell growth;Cell Physiology;Cell Proliferation;Cells;Characteristics;chemotherapy;Clonal Evolution;Collaborations;Communication;Critical Pathways;Cues;cytokine;Data;design;Development;differential expression;Disease;disease heterogeneity;Disease Progression;DNA Damage;Drug resistance;Drug Targeting;Ectopic Expression;effective therapy;FLT3 gene;gain of function;Gene Expression Profiling;Genes;Genetic;Genetic Heterogeneity;Goals;Growth;immune function;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;insight;Interleukin-1;Interleukin-1 beta;Investigation;knock-down;Knockout Mice;leukemia treatment;Leukemic Cell;leukemic stem cell;leukemogenesis;loss of function;Malignant - descriptor;MARCKS gene;Mediating;Mediator;Modeling;Molecular;mouse model;Mus;Mutation;new therapeutic target;Non-Malignant;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;Pathway interactions;Patients;pharmacologic;Phosphorylation;Phosphotransferases;pre-clinical;Process;progenitor;programs;Proliferating;receptor expression;Recurrent disease;replication stress;Reporting;Research;response;Role;Sampling;side effect;Signal Transduction;small molecule;small molecule inhibitor;Survival Rate;targeted agent;targeted treatment;Testing;therapeutic target;tool;transcriptome sequencing;Transgenic Mice;transplant model;Up-Regulation;Xenograft Model

PROJECT_TITLE: Mechanisms and targeting of inflammatory cytokine-driven expansion and progression in AML

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: MORGANTOWN

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE This project will identify the importance of tubulin modifications and the small GTPase ARL13B in the health of light-sensing photoreceptor cells. With a thorough understanding of the basic biology behind photoreceptor health, we hope to identify novel therapies for patients with inherited blindness.

PI_NAMEs: RAMAMURTHY, VISVANATHAN  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Acetylation;Acetyltransferase;Address;ADP-Ribosylation Factors;alpha Tubulin;Animal Model;Arl proteins;Biochemical;Biology;Blindness;Carboxypeptidase;Cell Culture Techniques;Cell Cycle;Cell Death;Cessation of life;Cilia;cilium biogenesis;Clinical;Complex;Cone;Deacetylase;Deacetylation;Defect;Dependence;Disease;disease model;Electrophysiology (science);Embryo;Exclusion;Fibroblasts;Future;Genetic;Genetic Models;Glean;Goals;GTP Binding Domain;HDAC6 gene;Health;Human;In Vitro;Inherited;inhibitor;Kinetics;Knock-in;Knock-out;Length;Light;Link;Maintenance;Mass Spectrum Analysis;Measures;Mendelian disorder;Microtubules;Modeling;Modification;Molecular;Monomeric GTP-Binding Proteins;Morphology;mouse model;Mus;mutant;Mutation;Neurodegenerative Disorders;Neurons;novel;novel therapeutics;Patients;photon-counting detector;photoreceptor degeneration;Photoreceptors;Post-Translational Protein Processing;preservation;prevent;programs;Protein Family;protein folding;Protein Subunits;Proteins;Recurrence;Regulation;Research;Resistance;response;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;Rod;Role;sensory system;Signal Transduction Pathway;small molecule inhibitor;Structure;superresolution microscopy;Testing;trafficking;Translating;Tubulin;Variant;Vision;Visual;Western Blotting;Zebrafish

PROJECT_TITLE: Importance of small GTPases in photoreceptor function

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: MD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Narrative In spite of clear evidence that homeless adults have poor access to essential health services and that supportive housing can mitigate some consequences of homelessness, not enough is known about ways Medicaid and supportive housing policies can help reduce homelessness-related healthcare gaps. This project will analyze 10 years of linked homeless services and Medicaid data in NJ and PA to quantify the contribution of homelessness to gaps in healthcare access and evaluate how permanent supportive housing can help remedy those gaps. Project findings will inform Medicaid and supportive housing policies and programmatic strategies for improving healthcare access among homeless adults and reducing associated racial/ethnic and rural access disparities.

PI_NAMEs: CANTOR, JOEL C (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: access disparities;Accident and Emergency department;Address;Adult;Affordable Care Act;African American;African American population;Age;Ambulatory Care;Area;behavioral health;beneficiary;care outcomes;Chronic;Communicable Diseases;Communities;cost effective;Data;Death Rate;Disparity;Disparity population;disparity reduction;Effectiveness;Elements;Emergency Situation;Engineering;ethnic disparity;Ethnic Origin;experience;Face;falls;Focus Groups;Funding;Geography;Health;health care availability;health care disparity;health care service;health care service utilization;health management;health service use;Health Services;Healthcare;high risk;Hispanic;Hispanic Populations;Homeless persons;homeless shelters;Homelessness;Hospitals;Housing;Improve Access;improved;Income;Inpatients;interest;Intervention;Knowledge;Latinx population;Link;Managed Care;Measures;Medicaid;Medicaid eligibility;Medicine;Mental disorders;Mental Health;Minority Groups;Modeling;Morbidity - disease rate;mortality;New Jersey;novel;Patients;Pattern;Pennsylvania;Persons;Policies;Population;population based;Population Heterogeneity;Population Study;Primary Care;programs;Qualitative Research;Race;racial disparity;Records;recruit;Reduce health disparities;Research;Research Methodology;Risk;Role;Rural;rural disparities;Rural Population;Sampling;Services;social health determinants;Social Work;socioeconomic disadvantage;substance use;substance use treatment;supported housing;Time;Translational Research;Traumatic injury;trend;United States National Academy of Sciences;urban area

PROJECT_TITLE: The Role of Homelessness and Supportive Housing in Healthcare Disparities among Adults in Medicaid

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Vaccine Related

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Project Narrative The proposed project will examine patterns and predictors of change in alcohol misuse since the outbreak of the COVID-19 pandemic in coastal communities surrounding the Gulf of Mexico. Two factors unique to COVID-19 are massive increases in unemployment and growing feelings of loneliness caused by stay-at-home orders, both of which might change people's drinking behaviors over time. The study will use 4 waves of a longitudinal survey to answer critical questions about interactions between risk and protective factors, the role of stress and trauma, the co-occurrence of mental health symptoms, and reactions to prior disasters in the region.

PI_NAMEs: AYER, LYNSAY  (contact)

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: Address;Adult;adverse outcome;Affect;Age;Alcohol consumption;alcohol misuse;alcohol use disorder;American;Baseline Surveys;binge drinking;Black race;Businesses;Cessation of life;Characteristics;clinical practice;cohort;Communities;Consumption;Coping Skills;Country;County;COVID-19;COVID-19 impact;COVID-19 outbreak;COVID-19 pandemic;Data;Data Collection;Disasters;drinking;drinking behavior;Employment;epidemiology study;ethnic minority;Ethnic Origin;Event;experience;Feeling;Florida;Frequencies;Future;gulf coast;Heavy Drinking;Hurricane;Individual;infection rate;Job loss;Knowledge;Loneliness;Longitudinal Studies;Longitudinal Surveys;Louisiana;Marketing;men;Mental Health;Mexico;National Institute on Alcohol Abuse and Alcoholism;Neighborhoods;Oils;pandemic disease;Participant;Pattern;Persons;Policies;Population;post-COVID-19;Productivity;Prospective Studies;protective factors;psychosocial;public health emergency;public health research;Race;racial minority;Reaction;Recording of previous events;Repetitive Sequence;Reporting;Research;resilience;Resources;Respondent;response;Retrospective Studies;Risk;Risk Factors;risk mitigation;Role;Sampling;school closure;Scientific Advances and Accomplishments;sex;social;stay-at-home order;Stress;stressor;Stretching;Surveys;Symptoms;Technology;Texas;Time;Trauma;trauma exposure;Unemployment;United States;Vaccinated;Vaccination;Vaccines;Variant;Woman;Work

PROJECT_TITLE: COVID Impacts on Alcohol Use in Communities Affected by Repeated Disasters

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Project Narrative Large-scale studies have identified thousands of genetic variants associated with immune diseases, most of them located in regions of the genome that alter gene expression. However, in most cases, it is not known which of these variants drive disease phenotypes, nor their mechanism of action. In this proposal, we will integrate complementary experimental approaches to identify potential causal genetic variants and determine the molecular mechanisms by which they affect gene expression and lead to immune disease. !

PI_NAMEs: SIGGERS, TREVOR  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Accounting;Address;Affect;Allelic Imbalance;Autoimmune Diseases;Automobile Driving;B-Lymphocytes;Binding;Binding Sites;Biological Assay;biophysical model;Biophysical Process;Biophysics;causal variant;Cell Culture Techniques;Cell Line;cell type;Cells;Chromatin;chromatin immunoprecipitation;CISH gene;cofactor;Complex;complex data;CRISPR/Cas technology;Data;data integration;Data Set;Disease;disease phenotype;Disease susceptibility;DNA;DNA Binding;Elements;Enhancers;Etiology;Foundations;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic study;Genetic Transcription;genetic variant;Genome;genome wide association study;genome-wide analysis;Genomic approach;Goals;Human;Immune;Immune System Diseases;Immunologic Stimulation;Immunological Models;immunoregulation;in vivo;inhibitor therapy;Lead;Link;Macrophage;Maps;Mass Spectrum Analysis;Measurement;Methods;Modeling;Molecular;Mutagenesis;Nucleotides;Pharmaceutical Preparations;Predisposition;promoter;Proteomics;Regulatory Element;Reporter;Reporter Genes;Resolution;Rest;Single Nucleotide Polymorphism;Stimulus;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic target;Translating;Untranslated RNA;Variant

PROJECT_TITLE: Biophysical and functional characterization of immune-related regulatory elements and noncoding variants

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Insufficient knowledge of early life immune development limits our ability to optimize vaccines and prevent, detect, and treat conditions such as infection and asthma. To gain insight into how early life immune development impacts vaccine responses, health and disease we will: (a) employ a systems biology approach to comprehensively measures changes in molecules such as proteins (proteomics), metabolites (metabolomics) and the bacteria that live in our gut and nose (microbiome); and (b) use liquid (plasma) and cells from human blood donations to model immunity and responses to potentially protective agents outside the body (in vitro). Identifying molecular patterns (“signatures”) of infant immune development that correspond to vaccine-responsiveness, susceptibility or resistance to respiratory infection and asthma will accelerate discovery and development of tests to better predict the risk of childhood disease and guide the development of medical interventions (e.g., vaccines) to optimize immune development, prevent disease and enhance childhood health.

PI_NAMEs: LEVY, OFER  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Acceleration;adaptive immune response;Adjuvant;Adult;Africa;age related;Asthma;Australasia;Bacteria;biobank;Bioinformatics;bioinformatics tool;Biological Assay;Biological Markers;Biological Models;Birth;Blood Donations;Blood Volume;Cells;Childhood;Clinical;clinical phenotype;cohort;Communicable Diseases;Coupled;Data;Development;Disease;Enrollment;Epigenetic Process;experience;Goals;Greek;Growth;gut microbiome;Health;high risk;Human;Human body;Immune;Immune system;Immunity;Immunologics;Immunomodulators;in silico;in utero;In Vitro;in vitro Model;Individual;infancy;Infant;Infection;infection risk;Innate Immune Response;insight;inter-individual variation;Intervention;Knowledge;Life;Liquid substance;Measures;Mediating;Medical;Memory;metabolomics;microbiome;Modeling;Molecular;Molecular Profiling;Mucous Membrane;multiple omics;Newborn Infant;North America;Nose;novel strategies;Organ;Pathway interactions;Pattern;Pediatric cohort;Phenotype;Physiological;Plasma;Positioning Attribute;predictive marker;Predisposition;prevent;Prognostic Marker;programs;prospective;Protective Agents;Proteins;Proteomics;PRTN3 gene;Publishing;Resistance;respiratory;Respiratory Disease;Respiratory Tract Infections;response;Risk;risk prediction;Sampling;Shapes;specific biomarkers;System;Systems Biology;Testing;tool;Training;Translating;vaccine response;Vaccines;Validation

PROJECT_TITLE: Immune development in early life (IDEAL) shapes vaccine response, respiratory infectious diseaseand asthma


PROJECT_TERMS: Adherence;Asthma;Cells;Childhood;Clinical;Communicable Diseases;Communication;conflict resolution;Data;data management;design;Development;Dissection;Ensure;Epigenetic Process;Funding;Geography;Goals;Human;Immune;Immune response;Immunology;improved;in silico;In Vitro;Infant;Infrastructure;Intellectual Property;inter-institutional;International;Leadership;Life;material transfer agreement;Mediating;meetings;Molecular;Outcome;Predisposition;Process;Productivity;programs;Progress Reports;Property Rights;Proteomics;PRTN3 gene;Recommendation;Research Personnel;Research Project Grants;respiratory;Shapes;Structure;symposium;synergism;Systems Biology;Technology;Teleconferences;timeline;transcriptomics;United States National Institutes of Health;vaccine response;Vaccines;vaccinology;Work

PROJECT_TITLE: Administrative Core: IDEAL shapes vaccine response, susceptibility to respiratory infectious disease and asthma


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Pancreatic cancer is the third leading cause of cancer-related death in the United States and is associated with a grim 9% 5-year survival rate. The overall goal of this application is to develop a therapeutic strategy using a new therapeutic agent which by targeting tumor cell DNA repair will improve the efficacy of immunotherapy and radiation. The preclinical studies in this proposal will form the foundation for future clinical trials in patients with inoperable pancreatic cancers ultimately leading to urgently needed advances in the clinical management of locally advanced pancreatic cancer.

PI_NAMEs: MORGAN, MEREDITH A (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Abbreviations;advanced pancreatic cancer;Affect;Antigen-Presenting Cells;Apical;ATM deficient;Cancer Detection;Cancer Etiology;CD8B1 gene;Cell Count;Cell Physiology;Cells;Cessation of life;CHEK2 gene;clinical candidate;clinical development;clinical efficacy;Clinical Management;Clinical Trials;Combined Modality Therapy;Cytoplasm;Data;Defect;DNA;DNA Damage;DNA Repair;Dose;effector T cell;efficacy evaluation;Foundations;Fractionation;Future;Genetic;Genetically Engineered Mouse;Goals;IFNAR1 gene;Immune;immune activation;immune checkpoint blockade;Immune response;immunogenic;Immunologic Surveillance;Immunologics;immunoregulation;Immunotherapy;improved;in vivo;inhibitor;innate immune pathways;Innate Immune Response;innate immune sensing;Interferon Receptor;Interferon Type I;Interferons;Ionizing radiation;Link;Macrophage;Malignant neoplasm of pancreas;Mediating;Mediator;Mission;Natural Immunity;Nature;neoplastic cell;novel;novel therapeutics;Oncogenes;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic neoplasm;Pathway interactions;Patients;Pattern recognition receptor;pharmacodynamic biomarker;pharmacologic;Phosphotransferases;preclinical study;Production;programmed cell death ligand 1;Proteins;Proto-Oncogene Proteins c-akt;Radiation;Radiation Dose Unit;radiation response;Radiation therapy;Refractory;Regulation;replication stress;response;Role;Signal Pathway;Signal Transduction;small molecule inhibitor;Stimulator of Interferon Genes;Survival Rate;synergism;T cell infiltration;T-Lymphocyte;TBK1 gene;Testing;Therapeutic;Therapeutic Agents;Treatment Efficacy;tumor;tumor DNA;tumor growth;Tumor Immunity;tumor microenvironment;type I interferon receptor;United States;United States National Institutes of Health

PROJECT_TITLE: Targeting the DNA damage response in combination with radiation to induce innate immunity and improve immunotherapy efficacy in pancreatic cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Asthma;Biotechnology;Data Science;Immunization;Infectious Diseases;Lung;Networking and Information Technology R&D (NITRD);Vaccine Related

PI_NAMEs: OZONOFF, AL  (contact)

PROJECT_TERMS: Architecture;archive data;Archives;Articulation;Asthma;Bioinformatics;Biological Assay;Biological Markers;Biometry;biosignature;Child Health;Childhood;Clinical;Clinical Data;clinically relevant;cloud based;cloud storage;cohort;Collaborations;Communicable Diseases;Communities;Computer software;computerized tools;computing resources;Data;data access;data acquisition;Data Analyses;Data Analytics;data archive;Data Files;data infrastructure;data integration;data management;Data Set;data sharing;Data Sources;data standards;Data Storage and Retrieval;demographics;Deposition;design;Development;digital;Disease;Disparate;Environment;epigenomics;experimental analysis;Experimental Designs;FAIR principles;Gene Expression;Goals;Health;heterogenous data;high dimensionality;Human Resources;Immune;Immune system;improved;In Vitro;Infrastructure;innovation;insight;Institution;Intervention;Knowledge;Life;Link;metabolomics;Metadata;Methods;microbiome;National Institute of Allergy and Infectious Disease;operation;Outcome;Pathway interactions;Personnel Staffing;predict clinical outcome;Predisposition;Process;Productivity;prognostic;Proteomics;public repository;quality assurance;Quality Control;relational database;repository;Reproducibility;Reproduction;Research;Research Project Grants;Resources;respiratory;Respiratory Tract Infections;response;sample collection;Sampling;Secure;Security;Services;Shapes;Source;Statistical Data Interpretation;synergism;Systems Analysis;Systems Biology;transcriptome sequencing;transcriptomics;United States National Institutes of Health;user-friendly;vaccine response;Vaccines;Work

PROJECT_TITLE: Data Management & Analysis Core: IDEAL shapes vaccine response, susceptibility to respiratory infectious disease and asthma


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Cocaine;Drug Abuse (NIDA only);Neurosciences;Prevention;Stimulant Use and Misuse;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Chronic cocaine use (as well as comorbid cigarette smoking and alcohol use) can cause vascular disease. Although the Crack-Cocaine epidemic from the mid-1980s has lessened, with a 3-fold increase in emergency department cocaine-related visits since the end of the 1990s, the vascular consequences of chronic drug use are evident among addicted individuals of that generation. There is a public health imperative to detect early markers of vascular disease, as associated with brain function, to reduce excess morbidity and premature mortality, especially in this aging population.

PI_NAMEs: ALIA-KLEIN, NELLY  (contact);FAYAD, ZAHI A.;GOLDSTEIN, RITA Z

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: 3-Dimensional;Accident and Emergency department;Address;Age;Aging;aging population;Alcohol consumption;Area;Arterial Fatty Streak;Arteries;Atherosclerosis;Attention;Autopsy;Bilateral;Blood;Blood Vessels;Brain;Brain region;Cardiovascular Diseases;cardiovascular emergency;cardiovascular risk factor;Carotid Arteries;Carotid Artery Diseases;Carotid Artery Plaques;Carotid Stenosis;Cells;Cerebral hemisphere;Cerebral Ischemia;Cessation of life;Chronic;cigarette smoking;Clinical;Cocaine;Cocaine Dependence;cocaine use;Cocaine use disorder;Cognitive;cognitive function;cognitive task;comorbidity;Complex;cost;Crack Cocaine;craving;Darkness;Detection;Diagnosis;Disease;Disease Marker;drug addict;Drug Addiction;Drug usage;early detection biomarkers;Early Diagnosis;Emergency Situation;Endothelium;Epidemic;Executive Dysfunction;executive function;Fatal Outcome;fluorodeoxyglucose;Functional Magnetic Resonance Imaging;functional MRI scan;Gender;Generations;Guide prevention;high risk;Hybrids;Image;Impaired cognition;Impairment;in vivo;Individual;Inflammation;Internal carotid artery structure;Intervention;Link;Macrophage;Magnetic Resonance Imaging;Measures;Memory;Memory impairment;Methods;Morbidity - disease rate;neural network;Neurologic;Neuropsychological Tests;new technology;non-invasive imaging;opioid use;Pathology;Population;Positron-Emission Tomography;pre-clinical;Prefrontal Cortex;Premature Mortality;prevent;Process;Proliferating;Public Health;radiotracer;Reporting;Rest;reward processing;Rewards;Risk;Scanning;Series;Severities;Societies;Structure;substance use;Surface;Symptoms;Target Populations;Thick;Time;Tobacco use;Toxic effect;ultrasound;vascular abnormality;Vascular Diseases;vascular inflammation;vasoconstriction;Visit;X-Ray Computed Tomography

PROJECT_TITLE: Atherosclerosis in cocaine addiction: imaging risk with PET/MR

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Asthma;Biotechnology;Clinical Research;Immunization;Infectious Diseases;Lung;Pediatric;Precision Medicine;Prevention;Vaccine Related

PI_NAMEs: PICHICHERO, MICHAEL E (contact)

PROJECT_TERMS: 3 year old;Adjuvant;Africa;Age;Antibody Response;Asthma;biobank;biomarker development;biomarker discovery;Canada;Child;Child Health;Clinical;clinical phenotype;Clinical Trials;cohort;Communicable Diseases;Data;data exchange;Development;Disease;early childhood;Functional disorder;Future;Geography;Goals;Growth;Health;Hypersensitivity;Immune;immune modulating agents;Immune response;Immune system;Immune System Diseases;Immunologic Memory;Immunologics;Immunology procedure;Impairment;Incidence;Infant;Infection;Infection prevention;Intervention;Intestines;Investigation;Lead;Life;Longitudinal cohort study;Measures;metabolomics;microbiome research;Modernization;Molecular;mortality;Mucous Membrane;multiple omics;Nasopharynx;Papua New Guinea;Phenotype;Population;predictive marker;Predisposition;prevent;prospective;Prospective cohort;Proteins;Proteomics;recruit;respiratory;Respiratory Tract Infections;Sampling;Secure;Shapes;Systems Biology;Testing;tool;transcriptomics;Vaccination;vaccine response;vaccine-induced antibodies;Vaccines;Validation;Variant

PROJECT_TITLE: Clinical Core: IDEAL shapes vaccine response, susceptibility to respiratory infectious disease and asthma


PI_NAMEs: MOHN, BILL  (contact)

PROJECT_TERMS: Address;American;Asthma;Benchmarking;Canada;Child;Childhood;Clinical;clinical phenotype;clinical predictors;Cloud Service;cohort;Collaborations;college;Communicable Diseases;comparative;computerized tools;Data;data management;Development;DNA;Ensure;Foundations;Gene Frequency;Generations;Health;Immune;Infant;Infection;insight;Investigation;large datasets;Lead;Life;Link;Measures;Metabolism;metagenome;Metagenomics;microbiome;microbiome analysis;microbiome research;Molecular;nasal microbiome;Nasopharynx;Nose;Outcome;Pathologist;Phenotype;Population;Predisposition;programs;Prokaryotic Cells;prospective;Protocols documentation;PRTN3 gene;Publishing;quality assurance;Resolution;respiratory;Respiratory Tract Infections;Role;rRNA Genes;Sampling;Secure;Shapes;Shotgun Sequencing;Shotguns;Standardization;stool sample;Supervision;Taxonomy;therapeutic target;vaccine response;Western Australia;Work

PROJECT_TITLE: Microbiome Core: IDEAL shapes vaccine response, susceptibility to respiratory infectious disease and asthma


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Microbiome;Neurosciences;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Tuberous Sclerosis

ORG_CITY: EAST LANSING

ORG_DEPT: PEDIATRICS

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE  Brain lesions and associated epilepsy are a significant challenge for patients with the genetic disease Tuberous Sclerosis Complex (TSC). Given the clinical diversity in TSC and the varying severity of the disease, it remains unclear which patients will develop debilitating symptoms as a result of tumor growth, thus making surveillance and disease management difficult. In order to inform more personalized treatment approaches for TSC patients, we aim to understand if genome sequencing data can be used to predict disease severity and to associate genetic modifiers with biological outcomes.

PI_NAMEs: VAUGHAN, ROBERT MARK (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 3-Dimensional;Acetylesterase;anti-cancer research;Area;bacterial resistance;Basic Science;Binding;Biochemical;Biochemistry;Biological;Biophysics;Brain;cancer cell;cancer type;career;Cell model;Cell Proliferation;Cellular biology;Chromatin;Clinical;Clinical Research;Colon;Colorectal Cancer;Complement;cortical tubers;CRISPR/Cas technology;Data;debilitating symptom;design;Development;Diagnosis;Disease;Disease Management;DNA;DNA Binding;DNA biosynthesis;DNA Ligases;DNA Methylation;DNA Modification Methylases;DNA Repair;Elements;Enzymatic Biochemistry;Epigenetic Process;epigenome;epigenomics;Epilepsy;Exposure to;Fellowship;Future;Gene Expression Regulation;gene repair;Genetic;Genetic Diseases;Genetic study;genome editing;genome sequencing;Genomics;Genotype;Goals;Health;Heterogeneity;Histone H3;Histones;Homologous Gene;Human;In Vitro;in vivo;infancy;insight;interest;Intestinal Cancer;Intestines;Invaded;Investments;Lesion;Ligase;Link;Linker DNA;Maintenance;Malignant Neoplasms;Messenger RNA;Metabolic;Metabolism;Methyltransferase;microbial;microbiome;microbiome research;microorganism;Modeling;Molecular;mouse model;Mutation;Neoplasm Metastasis;next generation sequencing;Okazaki fragments;Oncogenic;Oncoproteins;Organoids;Outcome;Pathogenicity;Patients;Pattern;personalized medicine;Phase;PHD Finger;Phenotype;Postdoctoral Fellow;precision medicine;Process;Protein Biochemistry;protein function;Proteins;recruit;Research;Research Personnel;Research Project Grants;research study;Research Training;Resistance;Ring Finger Domain;Role;screening;Severities;Severity of illness;Shapes;Signal Transduction;skills;structural biology;Subependymal Giant Cell Astrocytoma;Syndrome;Techniques;Technology;Therapeutic;therapeutic target;Training;Translational Research;Tuberous Sclerosis;tumor;Tumor Burden;tumor growth;tumor progression;two-dimensional;Ubiquitin;ubiquitin-protein ligase;undergraduate research;Up-Regulation

PROJECT_TITLE: Characterizing genetic modifiers in tumor burden of Tuberous Sclerosis Complex


PI_NAMEs: STEEN, HANNO  (contact)

PROJECT_TERMS: Affect;Aliquot;Antibody Response;Asthma;Biological;Biological Markers;biomarker identification;Birth;Blood;Cells;chemokine;Child;Childhood;Clinical;clinical phenotype;clinically relevant;Communicable Diseases;comorbidity;Complement;Consumption;COVID-19;COVID-19 patient;cytokine;Data;data management;Development;Diagnosis;Dimensions;Disease;early childhood;Early treatment;endophenotype;Epigenetic Process;Exhibits;Extravasation;Frequencies;Goals;Growth;Health;high risk;Hospitalization;Hour;Human;Immune;Immune system;Immunologics;Immunology;Immunophenotyping;immunoregulation;Impairment;In Vitro;infancy;Infant;Infection;Infrastructure;insight;interest;Intervention;Life;liquid chromatography mass spectrometry;Maps;Measurement;metabolome;metabolomics;Methods;Microbe;Molecular;Molecular Profiling;Mucous body substance;Nasal cavity;Nasopharynx;National Institute of Allergy and Infectious Disease;neonate;Newborn Infant;Nose;novel strategies;Outcome;pathogen;Pathway interactions;Pattern;Pharyngeal structure;Phenotype;Plasma;Predisposition;Prevention;Process;Prognosis;Proteins;Proteome;Proteomics;PRTN3 gene;Publishing;Research;Resolution;respiratory;Respiratory System;Respiratory Tract Infections;Risk;Role;Sampling;Services;Shapes;System;Testing;Time;Tissues;Vaccination;vaccine immunogenicity;vaccine response;Vaccines

PROJECT_TITLE: Proteomics and Metabolomics Core: IDEAL shapes vaccine response, susceptibility to respiratory infectious disease and asthma


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Aging and carrying the APOE e4 allele are the strongest risk factors for developing Alzheimer’s disease (AD). There is good evidence identifying changes in brain endosomal proteins and ApoE aggregation as early events predisposing to AD pathology. However, there is a major gap in our understanding of the mechanisms by which the ApoE4 protein regulates endosomal trafficking. In this project, we study how ApoE protein aggregates affect brain cellular functions in human and animal tissues. We study whether inducing ABCA1 activity to make ApoE HDL can reduce ApoE aggregation and ameliorate the brain endosomal congestion observed with ApoE4.

PI_NAMEs: YASSINE, HUSSEIN N (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: abeta deposition;Address;Affect;Affinity;age effect;Aging;Agonist;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Animal Model;animal tissue;Apolipoprotein E;apolipoprotein E receptor 2;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Binding;Brain;Brain imaging;brain tissue;Cell membrane;Cell Physiology;Cell surface;Cell Surface Proteins;Cognition;Cognitive;Early Endosome;Endocytosis;Endosomes;Event;Extracellular Space;frontal lobe;Genetic;Genetic Carriers;Genotype;Glutamate Receptor;Harvest;High Density Lipoproteins;Human;human tissue;imaging modality;Impaired cognition;in vivo;Inferior;Insulin Receptor;Label;Late Onset Alzheimer Disease;Lipids;loss of function mutation;Microglia;mouse model;Mus;Neurons;neuroprotection;novel;overexpression;particle;Pathway interactions;Peptides;Positron-Emission Tomography;protein aggregation;protein complex;protein transport;Proteins;Proteomics;Recycling;Regulation;resilience;Risk Factors;Role;Therapeutic;trafficking;Work

PROJECT_TITLE: ApoE, ABCA1 and endosomal dysregulation in AD


NIH_SPENDING_CATS: Asthma;Immunization;Infectious Diseases;Lung;Precision Medicine;Vaccine Related

PI_NAMEs: LASKY-SU, JESSICA A (contact)

PROJECT_TERMS: 6 year old;adaptive immunity;Address;antenatal;Asthma;Automobile Driving;Biological;Biological Markers;Biological Process;Categories;Childhood;Classification;Clinical;clinical phenotype;cohort;Collection;Communicable Diseases;Complex;Data;Data Discovery;Development;Disease;Ensure;Environmental Exposure;Epigenetic Process;epigenome;ethnic diversity;Etiology;follow-up;Future;Genetic;Growth;Health;Heterogeneity;Human;Immune;Immune Targeting;Immunity;Immunization;Immunologics;In Vitro;Individual;Infection;Life;Machine Learning;metabolome;metabolomics;microbiome;Molecular;Molecular Target;Multiomic Data;multiple omics;Natural Immunity;novel;Outcome;Pathway interactions;Phenotype;Play;precision medicine;Predisposition;Process;programs;prospective;Proteome;Proteomics;Research;respiratory;Respiratory Tract Infections;Role;Shapes;statistics;Systems Biology;targeted biomarker;therapeutic target;transcriptome;transcriptomics;vaccination outcome;vaccine response;Validation;Variant;Vitamin D

PROJECT_TITLE: Project 1: Multi-omic endotyping of vaccine response, susceptibility to respiratory infectious disease and asthma


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: NARRATIVE CAR-T cell therapy is an emerging option for cancer treatment, but its efficacy is limited, especially in solid tumors because the effector CD8+T cells that promote anti-tumor immunity become dysfunctional and exhausted in the tumor microenvironment (TME). Our studies demonstrate that Zbtb44, a member of ThPOK family of transcription factors forms a complex with the T-box transcription factor, Eomes which is critically essential for effector function of CD8+ T cells. In the ‘exhausted’ CD8+T cells, Trim47 degrades Zbtb44 and disrupts the Zbtb44-Eomes complex resulting in the inhibitory transcriptional profile. We aim to prevent CAR-T exhaustion by blocking the Zbtb44- Trim47 pathway. Our studies could lead to clinical trials to overcome the current limitations of CAR-T cells leading to improved outcome in patients with advanced solid tumors.

PI_NAMEs: POOJARY, VENUPRASAD K (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: anti-CTLA4 antibodies;anti-PD-1;Binding;Cancer Model;cancer therapy;CAR T cell therapy;Carcinoembryonic Antigen;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cell Therapy;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials;Colon Carcinoma;Complex;CRISPR/Cas technology;Dissection;Equilibrium;Event;exhaust;exhaustion;Family;Functional disorder;Gene Expression Profile;Immune;Immune checkpoint inhibitor;improved outcome;Interferons;MC38;Mediating;member;Molecular;Mus;novel;Pathway interactions;patient derived xenograft model;Patients;Play;Post-Translational Protein Processing;prevent;programmed cell death protein 1;promoter;protein complex;protein degradation;Regulation;Role;Solid Neoplasm;Sumoylation Pathway;T cell response;T cell therapy;Testing;therapeutic evaluation;therapeutic target;transcription factor;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-Infiltrating Lymphocytes;ubiquitin ligase;Ubiquitination

PROJECT_TITLE: Regulation of Zbtb44-Eomes complex in CD8+T cells and anti-tumor immunity

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Bioengineering;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: BLOOMINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE The proposed project seeks to improve overdose outcomes for individuals receiving therapeutic opioids. To improve recognition of overdose onset as well as problems with timely naloxone delivery and dosage, the project will develop an automated, portable system for detection and treatment of an opioid overdose in real time.

PI_NAMEs: GUO, FENG ;MACKIE, KENNETH  (contact)

PROGRAM_OFFICER_NAME: HUBNER, CAROL B

PROJECT_TERMS: Acoustics;Address;Anesthesiology;Animal Model;awake;Blood;Brain Death;Brain Injuries;Breathing;Cells;Cellular Phone;Cessation of life;Classification;Clinical Data;clinical pain;Collaborations;Consumption;convolutional neural network;Data;Depressed mood;Detection;detection platform;Devices;digital;dosage;Dose;Engineering;Exercise;Expert Systems;Failure;Fentanyl;Heart Rate;Human;human data;improved;Individual;Injections;innovation;Intervention;Letters;Machine Learning;machine learning algorithm;Medical;Medicine;Methods;Monitor;Morphologic artifacts;Motion;mouse model;Mus;Naloxone;naloxone dispensing;Needles;novel;Opioid;opioid overdose;Outcome;Overdose;Oxygen;Patients;Pattern;Physical activity;Physiological;portability;prescription opioid;prototype;Real-Time Systems;Research;Respiration;respiratory;sensor;Sleep;System;Therapeutic;therapeutic opioid;therapeutic patch;Therapeutic Uses;Time;Training;translation to humans;translational applications;translational potential;user-friendly;Variant;Ventilatory Depression;wearable sensor technology

PROJECT_TITLE: An automated portable system for detecting and treating opioid induced respiratory depression

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


PI_NAMEs: KOLLMANN, TOBIAS R. (contact)

PROJECT_TERMS: Acute;Age;Antibodies;Asthma;Benchmarking;Biological Markers;biomarker signature;Birth;Blood specimen;catalyst;Cells;Characteristics;Child;Childhood;Clinical;cohort;combinatorial;Communicable Diseases;Complex;Data;Data Set;Development;Disease;disorder risk;DNA Methylation;DNA methylation profiling;Early Diagnosis;Elements;Enhancers;Environment;environmental allergen;epigenetic marker;Epigenetic Process;epigenetic profiling;epigenetic regulation;epigenome-wide association studies;Event;Exhibits;Functional disorder;Genes;genetic signature;Genome;genome-wide;Genomics;Growth;Hypersensitivity;Immune;Immunity;Immunologic Memory;Immunologics;immunoregulation;Individual;Infection;insight;Intervention;Knowledge;Lead;learning algorithm;Life;Life Cycle Stages;Link;Machine Learning;Measures;Mediating;Methylation;microbial;microbiome;microbiota;Modeling;Modification;Molecular;mucosal microbiota;Mucous Membrane;novel;Outcome;Participant;pathogen;Pathologic;Pathway interactions;Performance;Perinatal;Peripheral;personalized intervention;Phenotype;potential biomarker;predictive marker;Predisposition;preventive intervention;Production;Prognostic Marker;prognostic model;promoter;prospective;Receptor Signaling;Recurrence;Regression Analysis;Reproducibility;resilience;respiratory;Respiratory Tract Infections;response;Role;Shapes;statistical learning;Subgroup;Systemic infection;Testing;Time;Training;Vaccination;vaccination outcome;vaccine immunogenicity;vaccine response;Vaccines

PROJECT_TITLE: Project 2: Epigenetic ontogeny of vaccine response, susceptibility to respiratory infectious disease and asthma


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Health promotion efforts among African American men have produced limited results – these men have lower health-related quality of life than all other racial/ethnic and gender groups in the United States. Findings from this study will provide insight on the feasibility, acceptability, and preliminary results of a theoretically-based tailored intervention to improve health-related quality of life among African American men, in addition to providing insight on the recruitment and retention of these men in health promotion efforts. Developing and implementing an effective intervention to improve health-related quality of life among these men can improve mortality rates, morbidity rates, and lower healthcare costs.

PI_NAMEs: WIPPOLD, GUILLERMO MANUEL (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: acceptability and feasibility;Address;African American;African American population;Behavior Therapy;Behavioral;Characteristics;Clinical Trials;Communities;community advisory board;community based participatory research;community engaged intervention;Control Groups;control trial;Data;Death Rate;design;Development;Diet;Dimensions;dissemination science;Educational workshop;effective intervention;efficacy evaluation;Enhancement Technology;Ensure;Ethnic Origin;experience;Focus Groups;Funding;Gender;Goals;Grant;Health;Health Care Costs;health disparity;Health Promotion;health related quality of life;high risk;implementation science;improved;Individual;innovation;insight;Intervention;intervention mapping;K-Series Research Career Programs;Knowledge;Life Expectancy;Lived experience;male health;Measures;Mediator;men;men of color;Mental Depression;Mentors;Mentorship;mHealth;minority communities;minority health;Modeling;Morbidity - disease rate;mortality;participant enrollment;participant retention;peer;Physical activity;Physical Function;population health;programs;psychologic;Race;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Methodology;Research Personnel;response;Risk;scale up;Scientist;sex;skills;social;social cognitive theory;Social Functioning;South Carolina;Stress;Structure;success;Testing;therapy development;Time;Training;Unhealthy Diet;United States;Waiting Lists;Writing

PROJECT_TITLE: Developing a Community-Informed, Peer-to-Peer Intervention to Improve Health-Related Quality of Life among African American Men


PROJECT_TERMS: Acceleration;adaptive immune response;adaptive immunity;Address;Adjuvant;Age;age related;age related changes;Allergens;Anti-Inflammatory Agents;Antigen Presentation;antigen-specific T cells;Antigens;Asthma;asthmatic;Attenuated Vaccines;Autologous;BCG Live;biobank;Biological Assay;Biological Markers;Boston;CD8-Positive T-Lymphocytes;Cells;Child;Child Health;Childhood;Clinical;clinical phenotype;cohort;Communicable Diseases;cytokine;Data;Development;Disease;Disease susceptibility;disorder subtype;Evaluation;Exposure to;Flow Cytometry;Gene Expression Profiling;Goals;Growth;Health;Human;human model;Immune;immune activation;immune modulating agents;Immune response;Immunological Models;Immunomodulators;In Vitro;in vitro Assay;in vitro Model;in vivo;Individual;Infant;Infection;Innate Immune Response;insight;Italy;Lead;Leukocytes;Life;Mediating;Memory;MHC Class I Genes;Modeling;Molecular;monocyte;Mononuclear;Natural Immunity;neutralizing monoclonal antibodies;novel;Participant;Pathway interactions;Pattern recognition receptor;Pediatric Hospitals;Peptides;peripheral blood;Phenotype;Plasma;Population;Predisposition;Prognostic Marker;programs;prospective;protein expression;Proteins;Publishing;respiratory;Respiratory Disease;Respiratory Tract Infections;response;Risk;Rome;Sampling;Secondary to;Serum;Shapes;Signal Pathway;Small Interfering RNA;small molecule;small molecule inhibitor;Sorting;Stimulus;System;Systems Biology;T-Cell Activation;T-Lymphocyte;Technology;Testing;Training;Translating;Translations;vaccine response;Vaccines

PROJECT_TITLE: Project 3: In vitro modeling to define mechanisms of childhood vaccine response, susceptibility to respiratory infectious disease and asthma


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE Gout, a metabolic condition causing the most common inflammatory arthritis, leads to painful flares and joint damage; fundamental questions remain about its development. Building on the advances made in our preceding NIH-funded research, and leveraging the unique resources of ongoing prospective cohort studies with decades of follow-up, confirmed incident gout cases, and rich dietary, lifestyle, biomarker, and medical data, we propose to determine the role of metabolites and gut microbiota in the pathogenesis of gout (particularly, hyperuricemia becoming gout) and gout’s distinctive sex predilection. We anticipate this rigorous approach will provide novel mechanistic insights in gout, thereby laying a foundation for new prevention strategies as well as novel predictive tools.

PI_NAMEs: CHOI, HYON K (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Adult;Affect;African American population;androgenic;Ascorbic Acid;Asia;Asian;Atherosclerosis Risk in Communities;Bacteria;Beverages;biobank;Biological Markers;Biology;Black race;Branched-Chain Amino Acids;burden of illness;Butyrates;cardiometabolism;Caring;Case Study;Cholesterol;Citric Acid;Clinical;Coffee;cohort;coronary event;Country;Dairying;Data;dehydroepiandrosterone;Development;Diet;dietary;Disease;Emergency department visit;equol;Estrone;Estrone-Sulfate;Etiology;Flare;follow-up;Follow-Up Studies;Foundations;Fructose;Funding;Gas Chromatography;Gene Expression;Generations;genetic risk factor;genetic variant;Genome;genome wide association study;Gonadal Steroid Hormones;Gout;gut microbes;gut microbiome;gut microbiota;Health Professional;Heart;High Prevalence;hormone regulation;Hormones;Hospitalization;Hyperuricemia;Immunity;Individual;Inflammation;Inflammatory;Inflammatory Arthritis;insight;Intestines;joint injury;Ketone Bodies;Life Style;lifestyle data;Liquid Chromatography;male;Mass Spectrum Analysis;Medical;men;Mendelian randomization;Metabolic;metabolome;metabolomics;Metagenomics;Microbe;microbial;microbiome;microbiota;monocyte;Nested Case-Control Study;Network-based;Nonesterified Fatty Acids;novel;Nurses' Health Study;Pain;Pathogenesis;Pathway interactions;Patients;phenome;Plasma;population based;Precipitation;predictive tools;Predisposition;Prevalence;Prevention;Prevention strategy;Primary Prevention;prospective;Prospective, cohort study;Pyrrolidonecarboxylic Acid;Recurrence;Regulation;Research;Resources;Risk;Risk Factors;Role;Sampling;Secondary Prevention;sex;Sex Differences;sociodemographics;Statistical Methods;Steroids;stool sample;success;Taxonomy;Testing;Testosterone;Training;trait;United States National Institutes of Health;Urate;Validation;western diet;Woman;Women's study

PROJECT_TITLE: NOVEL METABOLITE AND MICROBIOTA PATHWAYS FOR HYPERURICEMIA AND GOUT

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: ATHENS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: The relevance of this research to public health: Systemic cryptococcosis is a serious threat to public health, causing hundreds of thousands of deaths each year. This project is to characterize the RAM pathway that is essential for Cryptococcus adaptation to the host physiological conditions and consequently the ability of this fungus to cause disease. Findings from the proposed research will deepen our understanding of cryptococcal pathogenesis and suggest targets for the potential development of novel therapies to prevent or manage this fatal disease.

PI_NAMEs: LIN, XIAORONG  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: ACE2;Acquired Immunodeficiency Syndrome;Air;anti-fungal agents;Antifungal Therapy;Ascomycota;attenuation;base;Basidiomycota;Binding;Binding Proteins;Biological Process;Candida;Carbon Dioxide;Cells;Central Nervous System Diseases;Cessation of life;Chemicals;Clinical;comparative;Complex;Critical Pathways;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Cultural Backgrounds;Death Rate;Development;Disease;Exclusion;fungus;Future;Genes;genetic analysis;Goals;Growth;High temperature of physical object;Homologous Gene;Human;Immunoprecipitation;improved;Infection;Intravenous;Investigation;Meningoencephalitis;Messenger RNA;Microbe;Modeling;Molecular;Morphogenesis;mouse model;mRNA Translation;Mutagens;mutant;Names;novel;novel therapeutics;Pathogenesis;pathogenic fungus;Pathogenicity;Pathway interactions;Patients;phosphoproteomics;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Pilot Projects;Post-Transcriptional Regulation;posttranscriptional;prevent;Process;Proteins;Public Health;Research;response;RNA;RNA Processing;RNA Recognition Motif;Saccharomyces;stress granule;Suppressor Mutations;Temperature;trait;Transcript;transcription factor;transcriptome sequencing;Translational Repression;Translations;vaccine access;Virulence;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Define the molecular bases for cryptococcal adaptation to host conditions by the RAM pathway

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed research will validate new metabolic imaging approaches allowing for improved non-invasive assessment of impaired glucose metabolism in Alzheimer’s disease (AD). Upon clinical translation, the methods developed in this proposal will serve to ameliorate clinical management of people living with AD, help refine therapeutic regimens and, ultimately, lead to better outcome and patient quality of life.

PI_NAMEs: GORDON, JEREMY WILLIAM (contact);WILSON, DAVID M

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: 3-Dimensional;Acetates;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;APP-PS1;Automobile Driving;Biological Markers;Brain;brain metabolism;Cerebrum;Chemical Shift Imaging;Clinical;Clinical Management;Clinical Research;clinical translation;clinically relevant;cost;Data;Deoxyglucose;Detection;Deuterium;Disease;Disease Progression;Evaluation;experimental study;Family;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Foundations;Fumarates;Future;Glucose;glucose metabolism;glucose uptake;Glutamates;Glutamine;Goals;healthy volunteer;Human;Human Volunteers;Hydrogen;Image;imaging approach;imaging modality;Imaging Phantoms;Impairment;improved;in vivo;Intervention;Ionizing radiation;J20 mouse;Label;Lead;Magnetic Resonance Imaging;Measures;Metabolic;metabolic imaging;Metabolism;metabolomics;Methods;molecular imaging;Monitor;mouse model;Mus;Nervous System Disorder;novel;Outcome;Pathogenesis;patient stratification;Patients;personalized therapeutic;Persons;Phosphorylation;Physiologic pulse;Play;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;precision medicine;Process;Public Health;Quality of life;Regimen;Research;response;Role;Safety;sex;spectroscopic imaging;stable isotope;success;System;Techniques;Therapeutic;therapy development;tool;Translations;treatment response;uptake;Visualization;Water;Wild Type Mouse

PROJECT_TITLE: Imaging cerebral metabolic impairment in AD using Deuterium MRI

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ORG_NAME: DANA-FARBER CANCER INST

PHR: The overall purpose of this grant is to provide expertise in statistics and data management to support the research mission of the ECOG-ACRIN Cancer Research Group. Achievement of our objectives will enable ECOG-ACRIN to continue to produce high quality clinical studies that advance the care of cancer patients.

PI_NAMEs: GATSONIS, CONSTANTINE A.;GRAY, ROBERT J (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Achievement;Age;American College of Radiology;American College of Radiology Imaging Network;anti-cancer research;Area;Automobile Driving;Biological Markers;Biometry;cancer care;Cancer Patient;Clinical;clinical biomarkers;clinical investigation;Clinical Research;Clinical Trials;Collaborations;Communities;Computational Biology;computerized data processing;Conduct Clinical Trials;Dana-Farber Cancer Institute;Data;Data Analyses;Data Collection;Data Coordinating Center;data library;data management;Data Science;data submission;design;Diagnosis;Eastern Cooperative Oncology Group;Environment;Ethnic Origin;Foundations;Gender;Goals;Grant;high standard;Image;image archival system;imaging biomarker;imaging modality;Immunotherapy;improved;Investigation;Laboratories;Leadership;Medical Research;Methodology;Mission;Monitor;Morbidity - disease rate;multimodality;novel marker;novel therapeutics;operation;organizational structure;Outcome;Patient Outcomes Assessments;patient safety;Patients;Phase;phase III trial;Population;Procedures;Process;programs;Quality Control;quantitative imaging;Race;Research;Research Design;Research Support;Resources;Site;Statistical Methods;statistics;System;Therapeutic Intervention;tissue biomarkers;treatment adherence;Universities;Vision

PROJECT_TITLE: ECOG-ACRIN Network Group Statistics and Data Management Center


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Precision Medicine

PI_NAMEs: GRAY, ROBERT J (contact)

PROJECT_TERMS: American College of Radiology;American College of Radiology Imaging Network;Archives;Articulation;Biological Markers;Biometry;Collaborations;Communication;Communities;Dana-Farber Cancer Institute;Data;data archive;Data Coordinating Center;Data Set;data sharing;data submission;Databases;design;Development;Diagnostic;Eastern Cooperative Oncology Group;Ensure;Foundations;Funding;Human Resources;image archival system;imaging study;Leadership;Medical Research;Monitor;National Clinical Trials Network;operation;Procedures;programs;Publications;Research;Research Personnel;Resource Sharing;Resources;Role;statistics;The Cancer Imaging Archive;Therapeutic Studies;Universities

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE Mammals, including humans, are able to waste calories and generate heat to keep normal internal temperature when exposed to cold, a process that is being investigated by many groups as potential therapeutic target to treat obesity. The process requires careful systemic coordination of burning of many fuel sources, including sugars and fats, but how this occurs remains poorly understood. We propose here to use sophisticated state-of- the-art metabolic studies to quantify with precision what fuels are used, how much, and by what tissues, in acutely and chronic cold-exposed animals, ultimately providing a foundational quantitative framework for understanding how animals generate heat.

PI_NAMEs: ARANY, ZOLTAN P (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Acute;Adipose tissue;Adult;Alanine;Animals;awake;Biology;Blood;Body Temperature;Brown Fat;Burn injury;Calories;Carbohydrates;Carbon;carboxylation;Chronic;Citric Acid Cycle;Data;Development;Exposure to;Fasting;Fatty acid glycerol esters;fatty acid oxidation;Foundations;Gluconeogenesis;Glucose;Glutamine;Glycerol;Goals;Human;in vivo;Individual;Infusion procedures;Investigation;Isotope Labeling;Ketones;Kinetics;Label;Liver;Mammals;Maps;Mass Spectrum Analysis;Measures;Metabolic;metabolic abnormality assessment;Metabolic Pathway;metabolomics;Mus;Nature;Obesity;Organ;Organism;oxidation;Palmitates;Pathway interactions;Pharmacologic Substance;Play;Positioning Attribute;Process;Pyruvate;pyruvate dehydrogenase;recruit;Role;Skeletal Muscle;Solid;Source;sugar;Techniques;Technology;Temperature;Testing;Therapeutic;therapeutic target;Thermogenesis;Tissues;wasting;Work

PROJECT_TITLE: Comprehensive quantification of fuel use in cold-induced thermogenesis in vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(02)M]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Eye Disease and Disorders of Vision;Immunotherapy

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative  Human autoimmune uveitis is a potentially blinding and disabling inflammatory disease affecting approximately 2 million Americans, and current treatments do not cure the underlying disease nor provide long-term prevention of recurrence. This proposal investigates mechanisms, using both mice and human samples, to reprogram the immune system to prevent, suppress, and cure uveitis while preventing blindness.

PI_NAMEs: LEE, DARREN JAMES (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Adenosine;Affect;American;Antigen-Presenting Cells;Antigens;Autoantigens;Autoimmune;autoimmune uveitis;Blindness;bone;Cataract;CCR6 gene;Cells;Cervical lymph node group;Chronic;Clinic;clinically relevant;Decalcification;Dependence;Disabling;Disease;Disease remission;Eye;Eye Infections;Glaucoma;Goals;Home;Homing;Human;human model;Immune response;Immune system;Immunity;Immunization;Immunobiology;Immunoglobulins;Immunology;Individual;Infection;Inflammation;Inflammatory;Intervention;ITIM;Link;lymph nodes;Lymphoid Tissue;Mediating;migration;Modeling;mouse model;Mus;novel strategies;Pathway interactions;Patients;Peptic Ulcer;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Population;Predisposition;prevent;programmed cell death protein 1;programs;Publishing;receptor;Recovery;Recrudescences;recruit;recurrence prevention;Regulatory T-Lymphocyte;Relapse;relapse prevention;Resistance;Resolution;Role;Sampling;Secondary to;side effect;Site;Source;Spleen;Steroids;success;T-Lymphocyte;Techniques;Tissues;Translating;translational study;treatment strategy;United States;Uveitis;uveoretinitis;Vision research;Work

PROJECT_TITLE: Immunobiology of EAU Recovery Through the Melanocortin-Adenosinergic Pathway


PROJECT_TERMS: Address;American College of Radiology Imaging Network;Biometry;Collaborations;Computational Biology;Dana-Farber Cancer Institute;Data Analyses;Data Coordinating Center;Data Reporting;design;Development;Diagnostic;Eastern Cooperative Oncology Group;experience;imaging study;Lead;Leadership;Manuscripts;Methodology;Mission;Monitor;Outcome;Process;programs;Reporting;Research;Research Personnel;Research Support;Safety;statistics;Structure;Therapeutic Trials;Translational Research;Universities;Work

PROJECT_TITLE: Statistics Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Human Genome;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE Pediatric patients with relapsed or refractory solid tumors have dismal long-term survival rates, which have not improved over the past 2 decades. This proposal seeks to improve outcomes for these patients by genetically modifying T cells to attack solid tumors, evaluate their safety and antitumor activity in a clinical trial, and perform studies to learn what leads to success or failure of this treatment, with the goal of improving and refining our therapeutic approach. While focused on pediatric solid tumors, the mechanistic insights and tumor targeting strategies developed could readily be applied to other cancers in both children and adults.

PI_NAMEs: DERENZO, CHRISTOPHER C. (contact);GOTTSCHALK, STEPHEN

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Adoptive Transfer;Adult;Antigen Targeting;Antigens;antitumor effect;Applications Grants;Biopsy;bisulfite sequencing;Brain Neoplasms;CAR T cell therapy;CD19 gene;CD276 gene;CD28 gene;Cell surface;Cell Therapy;Cells;Cellular biology;Child;Childhood;Childhood Solid Neoplasm;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Research;Clinical Trials;Combined Modality Therapy;Correlative Study;cytokine;Data;design;Disease;effective therapy;engineered T cells;Ensure;experience;Gene Modified;Goals;high risk;Human;Immune;Immunotherapy;improved;improved outcome;in vivo;Infusion procedures;insight;Learning;Ligands;Malignant Neoplasms;Maximum Tolerated Dose;Morbidity - disease rate;mortality;Neuroblastoma;Normal tissue morphology;Osteosarcoma;Outcome;Patient-Focused Outcomes;Patients;pediatric patients;Phase;Phase I Clinical Trials;Population;pre-clinical;Pre-Clinical Model;Production;Proliferating;Protocols documentation;Refractory;Relapse;relapse prevention;Reproducibility;Research;research clinical testing;Rhabdomyosarcoma;Safety;Signal Transduction;single-cell RNA sequencing;Solid Neoplasm;Structure;success;Survival Rate;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;Text;Therapeutic;Translations;Treatment Failure;tumor;Tumor Antigens;tumor microenvironment;whole genome

PROJECT_TITLE: Enhancing B7-H3-CAR T cell therapy for pediatric solid tumors

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Malaria;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: NARRATIVE The fast-paced urbanization in Africa, changing climates and novel vectors are expected to impact malaria risk. Here we propose to conduct a spatio-temporal epidemiological study of malaria in Accra, Ghana, to better characterize urban malaria to inform appropriate control strategies.

PI_NAMEs: AWANDARE, GORDON AKANZUWINE;STRESMAN, GILLIAN  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Africa;African;Age;Area;Catchment Area;Cities;climate change;Clinical;Clinical Data;Communities;Community Surveys;Country;Cross-Sectional Studies;Data;Decision Making;Dedications;design;effectiveness evaluation;Ensure;Epidemiology;epidemiology study;evidence base;Falciparum Malaria;Ghana;Goals;Health care facility;health data;Health system;Heterogeneity;Household;Incidence;Individual;Infection;insight;interdisciplinary collaboration;Intervention;Investigation;Legal patent;Machine Learning;Malaria;malaria infection;malaria transmission;Maps;Measures;Methods;Modeling;Molecular;Monitor;novel;Parasites;Patient Self-Report;Pattern;Persons;Plasmodium falciparum;Population;Prevalence;primary outcome;programs;Proxy;Public Health;Questionnaires;Reporting;Research;Risk;Risk Factors;rural area;Seasons;Sensitivity and Specificity;spatial epidemiology;spatiotemporal;surveillance data;Surveys;System;Techniques;Testing;Time;time use;transmission process;trend;urban area;Urban Population;urban setting;Urbanization;vector

PROJECT_TITLE: Characterizing the spatial epidemiology of urban malaria infection in Accra, Ghana (MUSE)

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine

PI_NAMEs: MACDONALD, JEAN  (contact)

PROJECT_TERMS: Adverse event;American College of Radiology;American College of Radiology Imaging Network;anti-cancer research;Biometry;Cancer Therapy Evaluation Program;Clinical;Clinical Data;Clinical Data Update System;Collection;Common Terminology Criteria for Adverse Events;Communication;Complex;Computational Biology;computerized data processing;Dana-Farber Cancer Institute;Data;Data Collection;Data Coordinating Center;Data Element;data management;Data Management Resources;data standards;data submission;Databases;design;Development;Diagnostic;Eastern Cooperative Oncology Group;Eligibility Determination;Ensure;Evaluable Disease;Evaluation;Foundations;high standard;Human Resources;imaging study;informatics tool;Information Systems;Infrastructure;Institution;Libraries;Malignant Neoplasms;Medical;Medical Research;Medidata;Monitor;Oncology;operation;participant enrollment;Patients;Performance;performance site;pilot test;Policies;Procedures;Process;Protocols documentation;Reporting;repository;Research Personnel;Resolution;Security;Site;Source;statistics;Support System;System;Therapeutic Studies;tool;Training and Education;Training Programs;Universities;web interface;Work

PROJECT_TITLE: Data Management Core


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Social Determinants of Health

ORG_CITY: BOGOTA

ORG_COUNTRY: COLOMBIA

ORG_FIPS: CO

ORG_NAME: UNIVERSITY OF THE ANDES

PHR: PROYECT NARRATIVE Project: Graduate Program in Bioethics in Research PD/PI Names: Montoya, Juny and Fernández Pinto, Manuela Organization: University of los Andes Project Period: 07/05/2022 - 06/30/2027 The master’s program in Bioethics in Research from University of Los Andes will be offered jointly by the Center of Applied Ethics, the School of Medicine, and the School of Economics, offering a unique interdisciplinary approach to the study of bioethics, with an emphasis on research ethics and the health sciences. As an online program, the master’s program will fill the shortage of quality education in Bioethics and Research Ethics not only in Colombia, but in other Latin American countries. With an innovative design driven by active, practice-oriented, and problem-based learning, the program will ensure that participants develop the necessary skills and competencies to approach ethical challenges in health research today.

PI_NAMEs: FERNÁNDEZ PINTO, MANUELA ;MONTOYA, JUNY  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Address;Admission activity;Area;Awareness;Bioethics;Cognitive;cohort;Colombia;Communication;Competence;Country;Critical Thinking;curriculum development;Dedications;design;Development;Dimensions;Economic Conditions;Economics;Education;educational atmosphere;Educational Curriculum;Educational process of instructing;Ensure;Ethical Review;Ethics;Ethics Consultation;Fostering;Goals;Government Agencies;Grant;Health;health management;Health Sciences;Hour;improved;Individual;innovation;Institution;Institutional Review Boards;interdisciplinary approach;interest;Knowledge;Laboratories;Language;Latin America;Latin American;Lead;Learning;learning strategy;Literature;long term memory;Manuscripts;Master of Science;medical schools;Mentors;multidisciplinary;Names;Participant;pedagogical content;Personal Satisfaction;Persons;Pharmacologic Substance;Policy Analysis;Problem-Based Learning;Process;professor;programs;Public Health;Recommendation;Regulation;Research;Research Design;Research Ethics;Research Methodology;Resolution;Resources;Rights;Scholarship;Schools;Science;skills;social;Societies;socioeconomics;Students;Time;Trainers Training;Training;Training Programs;tutoring;Universities;virtual classroom;Visit;Work;Writing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(56)R]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The Fogarty African Bioethics Post-Doctoral Fellowship Program (FAB-PDF) is an 18-month advanced bioethics postdoctoral training program for scholars from sub-Saharan Africa who hold a bioethics-related PhD. This D43 renewal is a collaboration between Johns Hopkins University (USA), Makerere University (Uganda), and University of Oxford (UK) in which 10 select postdocs will spend modular, dedicated time in each institution, and in their home African institution, completing coursework, scholarly writing projects, a global health ethics leadership project, and participating in informal and formal global bioethics professional networks. By leveraging our experience and longstanding commitments along with well-developed institutional relationships, we offer this highly collaborative post-doctoral training program to further advance the analytic thinking, visibility, leadership capacity, and professional networks of the top doctorally-trained bioethics scholars from sub-Saharan Africa.

PI_NAMEs: ALI, JOSEPH ;KASS, NANCY E (contact);SEWANKAMBO, NELSON K

PROJECT_TERMS: advanced analytics;Africa;Africa South of the Sahara;African;Area;Bioethics;Bioethics Consultants;career networking;Collaborations;Communicable Diseases;Communities;Dedications;Doctor of Philosophy;Educational process of instructing;Educational workshop;Ethics;experience;Faculty;Feedback;Fellowship;Fellowship Program;Fostering;global health;Glues;Home;Hybrids;Individual;Institution;International;Leadership;Learning;Manuscripts;meetings;Mentors;post-doctoral training;Postdoctoral Fellow;programs;Research;Research Ethics;Resources;Scholars Program;Science;skills;symposium;Technology;Thinking;Time;Training;Training Programs;Uganda;Universities;virtual;webinar;Work;Writing

PROJECT_TITLE: Fogarty African Bioethics Post-Doctoral Training Program


PHR: PROJECT NARRATIVE Tissue-resident macrophages (TRMs) play fundamental roles in health and disease, thus unlocking the biology of these cells is key to gaining a deeper knowledge of many human pathologies. This proposal’s objective is to understand the role of the amino acid hypusine in the maintenance and function of TRMs. Our approach will add new insight into how TRMs carry out functions essential for life, and will establish if hypusine synthesis is a tractable route to modulate TRMs in contexts where they influence disease, such as with tumor-associated macrophages and cancer.

PI_NAMEs: PEARCE, ERIKA L (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Alveolar;Amino Acids;base;Biology;Bone Marrow;Bone Tissue;Cells;Cellular biology;Circulation;Colony-Stimulating Factor Receptors;comparative;Data;deoxyhypusine;deoxyhypusine monooxygenase;deoxyhypusine synthase;Development;Disease;eIF-5A;Embryo;enzyme substrate;Enzymes;fetal;fetal stem cell;Fibrosis;GATA6 transcription factor;Gene Expression Profile;Goals;Greater sac of peritoneum;Health;Heart;Hematopoietic;Homeostasis;Human Pathology;Hydroxylation;hypusine;Immune;Immunity;insight;Kinetics;Knowledge;Life;Lung;Lysine;Macrophage;Maintenance;Malignant Neoplasms;Mediating;Metabolism;monocyte;Mus;Myocardial Infarction;Organ;pathogen;Play;Polyamines;precursor cell;Process;programs;Property;Proteins;Publishing;Residencies;response;Role;Route;self-renewal;Shapes;Signal Transduction;Spermidine;T-Lymphocyte;Testing;Time;Tissues;Transcript;translation factor;Translations;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;Work;wound healing;Yolk Sac

PROJECT_TITLE: The Role of the Amino Acid Hypusine in the Maintenance and Function of Tissue-Resident Macrophages


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE Colorectal cancer (CRC) is a common cause of cancer death in the U.S. Yet, screening rates are less than optimal in many Federally Qualified Health Centers, even with new tests that can be done easily at home, such as the fecal immunochemical test (FIT). This study seeks to speed up the adoption of effective cancer prevention and control screening practices by promoting CRC screening in community clinics (rural and urban) in Central and Southwest Florida with added attention on repeat screening. A number of strategies will be implemented including low-literacy patient education combined with FIT distribution plus a cancer control champion. Our goal is to change the annual CRC screening rates at the clinics.

PI_NAMEs: GWEDE, CLEMENT K. (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Acceleration;Address;Adoption;Adult;Age;Agreement;Attention;Awareness;Cancer Control;Cancer Etiology;cancer health disparity;Cancer Intervention;cancer prevention;care outcomes;Caring;Cessation of life;Clinic;Clinical;Colonoscopy;Colorectal Cancer;colorectal cancer screening;Communities;community based participatory research;community clinic;Community Health;Community Health Systems;Comprehensive Health Care;Consolidated Framework for Implementation Research;cost;cost effective;Data;design;Disparity;Dissemination and Implementation;Drops;Early Intervention;Education;Educational Intervention;electronic medical record tool;Eligibility Determination;Evaluation;Evidence based intervention;Federally Qualified Health Center;Florida;Funding;Geography;Goals;Haitian;Health;health care service;Health Insurance;Healthy People 2020;Home;implementation cost;implementation process;implementation research;implementation science;implementation strategy;improved;Incidence;Income;Individual;Information Systems;Intervention;Language;Life;literacy;Maintenance;Malignant Neoplasms;Measures;medically underserved population;men;Methods;Mind;Modality;Modification;Monitor;mortality;novel;Outcome;Outcome Assessment;Outcome Measure;Patient Education;patient navigation;Patient Preferences;patient screening;Patient-Focused Outcomes;Patients;Policy Maker;Population Characteristics;practice setting;preference;primary care setting;Process;Process Measure;Program Evaluation;programs;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Personnel;Resource-limited setting;Resources;Risk;routine screening;Rural;rural area;Rural Population;scale up;screening;Screening for cancer;Spanish;Speed;System;Testing;Woman;Work

PROJECT_TITLE: CARES-REACH (Colorectal Cancer Awareness, Research, Education and Screening-Rural Expansion, Access and Capacity for Health)

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ORG_NAME: ECOG-ACRIN MEDICAL RESEARCH FOUNDATION

PHR: Project Narrative: The primary goal of ECOG-ACRIN is to provide the support necessary to conduct relevant and rigorous clinical trials, which benefit public health by improving the quality and standard of care for cancer patients.

PI_NAMEs: ODWYER, PETER J (contact);SCHNALL, MITCHELL D.

PROJECT_TERMS: Adolescent and Young Adult;Adult;advanced disease;advocacy organizations;Affect;American College of Radiology Imaging Network;anti-cancer research;Automobile Driving;biobank;Bioinformatics;Biological;Biological Assay;Biological Markers;biomarker driven;Biometry;Cancer Biology;Cancer Center;cancer clinical trial;Cancer Patient;Cancer Research Network;cancer therapy;Cancer Therapy Evaluation Program;cancer type;care outcomes;career development;Caring;Center for Translational Science Activities;Clinical Markers;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Communities;Community Clinical Oncology Program;Community Practice;comparative effectiveness;Complex;Dana-Farber Cancer Institute;Data;Data Analyses;Data Coordinating Center;data repository;Databases;Dedications;Development;Diagnostic Imaging;Discipline;Disease;Early Diagnosis;Eastern Cooperative Oncology Group;Effectiveness;Environment;Evolution;experience;Fostering;Foundations;Funding;Future;Goals;Image;image archival system;imaging study;Immunologics;Immunology;improved;improved outcome;Infrastructure;innovation;Institution;International;Intervention;Investigational Therapies;Laboratories;Lead;Leadership;Life;Malignant Neoplasms;member;Mentorship;Modeling;Molecular;Monitor;multidisciplinary;multimodality;National Clinical Trials Network;next generation;novel;Oncology;operation;Outcomes Research;Participant;Patient Outcomes Assessments;Patient Participation;Patients;Phase;Pilot Projects;Population;Positioning Attribute;Prevalence;programs;Public Health;quantitative imaging;Reporting;Research;Research Personnel;Resources;Risk;Science;scientific organization;Scientist;screening;Selection for Treatments;Site;Specialized Program of Research Excellence;standard of care;System;Therapeutic;Tissue Banks;Translating;treatment effect;trial planning;Universities

PROJECT_TITLE: ECOG-ACRIN Network Group Operations Center


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Precision Medicine

PI_NAMEs: ODWYER, PETER J (contact)

PROJECT_TERMS: Adult;American College of Radiology Imaging Network;anti-cancer research;biobank;Biological;Biological Markers;Biometry;Cancer Biology;Cancer Center;cancer clinical trial;Cancer Patient;cancer therapy;Cancer Therapy Evaluation Program;care outcomes;Center for Translational Science Activities;Clinical Markers;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Communication;Communities;Community Clinical Oncology Program;Community Practice;Complex;Dana-Farber Cancer Institute;Data;Data Analyses;Data Coordinating Center;Databases;Development;Eastern Cooperative Oncology Group;Environment;Funding;Generations;Goals;Group Structure;Image;imaging study;Immunologics;improved;improved outcome;Industry;Infrastructure;innovation;Investigational Therapies;Laboratories;Lead;Leadership;Malignant Neoplasms;Mentorship;Modeling;next generation;novel;operation;Participant;Patients;Population;Positioning Attribute;Prevalence;programs;Protocols documentation;quantitative imaging;Research;Research Personnel;Resources;Role;Science;scientific organization;Site;Specialized Program of Research Excellence;Structure;System;Translating;treatment effect;Universities


ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: NARRATIVE Thiol groups can undergo numerous modifications, making cysteine a unique molecular switch. Cysteine plays structural and regulatory roles as part of proteins or glutathione, contributing to maintain redox homeostasis and regulate signaling within and amongst cells. Not surprisingly therefore, cysteines are associated with many he- reditary and acquired diseases – the research described herein will elucidate regulatory functions performed by protein cysteine residues and provide a framework for understanding how mutation and/or (in)activation of this key amino acid can cause disease.

PI_NAMEs: CARROLL, KATE SUZANNE (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TITLE: Chemical Tools for Probing Cysteine Sulfenation and Sulfination Redox Biology

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]