ORG_DEPT: PSYCHIATRY

PHR: Project narrative Obesity is a major public health problem because of its high prevalence and causal relationship with serious medical diseases. Here, we will investigate how the release and function of the neurotransmitter dopamine is altered in the brains of obese mice, and how to rescue these changes to drive weight loss. This work is critical for understanding how obesity changes brain systems that govern feeding, and how to modify these systems to improve weight loss outcomes for people with obesity.

PI_NAMEs: KRAVITZ, ALEXXAI V (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: abuse liability;Amphetamines;Animals;Antipsychotic Agents;Body Weight;Body Weight decreased;Brain;Chronic;Clinical Treatment;Cross-Sectional Studies;Deep Brain Stimulation;design;diet and exercise;Disease;Dopamine;dopamine system;dopaminergic neuron;Eating;Electrophysiology (science);feeding;Fiber;Financial cost;Focused Ultrasound;Food;food consumption;Foundations;Goals;Health Benefit;High Prevalence;Hyperphagia;improved;in vivo;Intake;Intervention;Life;Link;Medical;mesolimbic system;Meta-Analysis;Methods;Mus;neuronal circuitry;Neuronal Plasticity;Neurons;neuroregulation;Neurotransmitters;novel;Nucleus Accumbens;Obese Mice;obese patients;Obesity;obesity treatment;optical sensor;Outcome;patch clamp;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Photometry;Physiological;Physiology;Protocols documentation;Public Health;reduced food intake;Research;Resistance;Rest;Role;side effect;Signal Transduction;Stimulant;Synapses;System;Testing;Therapeutic;Time;tool;Transcranial magnetic stimulation;treatment effect;United States Food and Drug Administration;Ventral Tegmental Area;Weight;Weight Gain;Weight-Loss Drugs;Work

PROJECT_TITLE: Dopaminergic control of obesity in mice

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: NR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Tuberculosis

ORG_CITY: MILWAUKEE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: The project will use a mixed-methods approach to examine the influence of actual and perceived immigration laws on Latinx immigrants' willingness to engage in three central population-level communicable disease management efforts—screening, contact tracing, and treatment. To ensure that the results of our research can be applied rapidly to public health practice, we will collaborate with colleagues at the National Association of City and County Health Officers (NACCHO) to explore the informational needs of public health practitioners tasked with addressing law and law-related concerns.

PI_NAMEs: GALLETLY, CAROL L (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Address;Agriculture;AIDS prevention;Area;Awareness;Behavior;behavior influence;Caring;Charge;Cities;Collaborations;Communicable Disease Control;Communicable Diseases;Communities;community engaged research;Community Health Aides;Community Health Nursing;community organizations;Complex;Contact Tracing;Country;County;COVID-19;COVID-19 pandemic;COVID-19 testing;data exchange;Development;Disease Management;disorder control;Documentation;Environment;experience;Feedback;Focus Groups;Funding;Gender;Government;Health;Health Personnel;Hepatitis B;Hepatitis C;HIV;HIV Seropositivity;Household;Human immunodeficiency virus test;Immigrant;Immigration;Individual;Infection;Intervention;Interview;intimate partner violence;Latinx;Laws;Lawyers;Legal;marginalization;Measures;Medical;member;Methods;metropolitan;Modeling;Nature;Occupational;Participant;Pattern;Perception;pilot test;Policies;Population;prevention service;Process;Public Health;public health intervention;Public Health Nursing;Public Health Practice;Recommendation;Reporting;Research;Research Personnel;residence;response;Rural;Sampling;Scanning;screening;Sentinel;Services;Severities;social;social stigma;Structure;Substance Use Disorder;success;Surveys;Testing;Time;Translating;transmission process;Tuberculosis;urban setting;Vaccination;virtual;willingness;Work;Writing

PROJECT_TITLE: Perceived Immigration Laws and Infectious Disease Control Measures

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: MORGANTOWN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROGRAM NARRATIVE The proposed research is relevant to public health as an urgent medical need exists to develop novel therapeutics to improve post-stroke recovery by mitigating the severity of ischemic brain damage. A unique therapeutic target, mitoNEET, has been identified and a novel tool, NL-1, has been developed to gain a better understanding of how mitoNEET modulation reduces stroke neuropathology and improves functional outcomes in aged male and female rats following MCAO. The proposed research is relevant to the missions of the NIA and NINDS by conducting basic science research aimed at improving the devastating effects caused by acute ischemic stroke and is relevant to the NIH by improving health by developing a library of compounds that can be employed as tools, probes and possibly therapeutics that will improve health through innovative research.

PI_NAMEs: GELDENHUYS, WERNER ;HUBER, JASON D (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;Address;Advanced Development;aged;Apoproteins;Apoptosis;Area;Attenuated;Basic Science;Bioenergetics;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier disruption;blood-brain barrier function;blood-brain barrier permeabilization;Brain;brain endothelial cell;Brain Injuries;brain iron;brain tissue;Cardiovascular system;Cause of Death;cell injury;Cell Respiration;Cells;Cellular Stress;cerebral microvasculature;Clinical Research;Communication;Consumption;Data;deprivation;design;disability;disabled;Disease;drug discovery;Endothelial Cells;Female;Foundations;Functional impairment;functional improvement;Generations;Glucose;Goals;Health;improved;improved outcome;In Vitro;in vitro Model;Infarction;injured;innovation;insight;interest;Iron;Ischemia;Ischemic Brain Injury;Ischemic Stroke;Knowledge;Libraries;Ligands;Link;Lipid Peroxidation;Literature;male;Mediating;Medical;Metabolic;Middle Cerebral Artery Occlusion;Mission;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;mitochondrial therapeutics;Modeling;Mus;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Nervous System Trauma;neuroinflammation;Neurologic;neuron loss;neuronal survival;Neurons;neuropathology;neuroprotection;new therapeutic target;novel;novel therapeutics;Oncogenic;Outer Mitochondrial Membrane;Oxidation-Reduction;Oxidative Stress;Oxygen;Parents;Pathway interactions;Phase;Pioglitazone;Play;post stroke;pre-clinical;Pre-Clinical Model;preclinical study;Proteins;Public Health;Rattus;Reactive Oxygen Species;repaired;Reperfusion Injury;Reperfusion Therapy;Research;response;Risk;Rodent;Role;sensor;Severities;Specificity;stressor;Stroke;stroke outcome;stroke recovery;Sulfur;targeted treatment;temporal measurement;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;therapeutic target;Tissues;tool;United States National Institutes of Health;Work

PROJECT_TITLE: mitoNEET as a therapeutic target for mitigating ischemic brain injury following MCAO

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Lung;Neurosciences;Prevention;Sleep Research

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Narrative Report Obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) are major public health problems. More work is needed to understand how to reduce the risk of heart attack and stroke in these patients particularly in people who have the overlap syndrome (OVS) of OSA plus COPD. Our research will help to raise awareness regarding OVS and how best to address OVS in individuals at risk of these complications.

PI_NAMEs: MALHOTRA, ATUL  (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Address;Adult;Affect;Age;Area;atherosclerosis risk;Autonomic nervous system;Awareness;Basic Science;Biological;Biological Markers;biomarker panel;Blood Vessels;cardiac magnetic resonance imaging;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cessation of life;Chronic Bronchitis;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Research;Congenital neurologic anomalies;Coronary heart disease;Cross-Sectional Studies;Data;design;Disease;effective intervention;Endothelium;Epidemic;Exclusion;Fibrosis;Galactose Binding Lectin;Gases;Generations;Heart failure;Hypoxemia;Hypoxia;imaging modality;improved;Individual;Inflammation;Injury;innovation;insight;interest;Intervention;Intervention Studies;Left;Literature;Lung;Lung Diseases;Mediating;men;MicroRNAs;mortality;Myocardial Infarction;Neurocognitive;novel;Obstructive Sleep Apnea;optimal treatments;Outcome;Outcome Measure;Oxidative Stress;Oxygen;Oxygen Therapy Care;Pathogenesis;Pathway interactions;Patients;Persons;Pharyngeal structure;Plasma;Population;positive airway pressure;potential biomarker;Prevalence;primary outcome;Prognosis;Public Health;Publications;Pulmonary Emphysema;Pulmonary Hypertension;Pulmonary Vascular Resistance;pulmonary vasoconstriction;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Research;respiratory;response;Right ventricular structure;Risk;risk prediction;Risk Reduction;Role;Sleep Apnea Syndromes;standard of care;Stroke;Syndrome;Technology;Testing;theories;therapy design;tool;Troponin;Vasodilation;Ventricular;Woman;Work

PROJECT_TITLE: The cardiovascular consequences of sleep apnea plus COPD (Overlap syndrome)

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Burden of Illness;HIV/AIDS;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE This exploratory project will use repeated nationally representative data from population-based HIV surveys to develop a cohort model with age-stratified transmission risk to predict the age distribution of HIV prevalence over time and the projected burden of noncommunicable diseases among people living with HIV. The construction of sex stratified one year age group sexual network profiles will enable more accurate transmission risk probabilities for the cohort model as well as allow for analysis of changes in sexual networks over time and factors associated with specific categories of sexual networks. The prediction of noncommunicable disease burden will be critical for resource planning and allocation and provide a foundation to accelerate health system response.

PI_NAMEs: STAFFORD, KRISTEN A. (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: 1 year old;Acceleration;Achievement;Acquired Immunodeficiency Syndrome;Address;Africa South of the Sahara;African;Age;Age Distribution;age group;age related;age stratification;Age Years;Aging;antiretroviral therapy;Botswana;burden of illness;Caring;Categories;Characteristics;cohort;Complex;Country;Data;Diabetes Mellitus;Diagnosis;Disease;Disease Management;disorder risk;Emergency Situation;Epidemic;epidemic response;epidemiological model;Epidemiology;experience;Foundations;Goals;Health;Health system;Healthcare;Healthcare Systems;HIV;HIV diagnosis;Hypertension;Incidence;Institution;Kidney Diseases;Knowledge;Letters;Life Expectancy;Malignant neoplasm of cervix uteri;Modeling;mortality;Network-based;Outcome;Participant;Persons;Population;population based;predictive modeling;Prevalence;Probability;programs;Research;Research Personnel;Resources;response;Risk;risk prediction;sex;Sexual Partners;Silver;Survey Methodology;Surveys;Testing;Time;Training;transmission process;Tsunami;Update;Viral;Work;Zambia

PROJECT_TITLE: Projecting the age shift in HIV prevalence in sub-Saharan Africa: a necessary epidemiologic step to prepare for the silver tsunami

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: RICHMOND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative  Molecular chaperones Hsp70s and Hsp110s form an essential chaperone machinery that plays multiple vital roles in maintaining cellular protein homeostasis, a fundamental cellular process that is inevitably linked to many human diseases including fungal infections. In this proposal, we aim to understand the basic molecular mechanism and function of Hsp110s in the Hsp70s/Hsp110s chaperone machinery using a unique and novel chemical tool that we recently identified, and thereby provide crucial insights into how to target them for treating fungal infections.

PI_NAMEs: LIU, QINGLIAN  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Affect;anti-fungal agents;Binding;Biochemical;Biological Process;Biology;Candida albicans;Cell Physiology;Cells;chaperone machinery;Chemicals;Complex;crosslink;Cryoelectron Microscopy;Cytosol;Data Reporting;design;Distant;Endoplasmic Reticulum;Eukaryota;Foundations;Future;Genetic;Goals;Growth;Guanine Nucleotide Exchange Factors;Homologous Gene;Human;human disease;improved;In Vitro;in vivo;inhibitor;innovation;insight;Learning;Link;Medicine;Modeling;Molecular;Molecular Chaperones;Mycoses;Names;new therapeutic target;novel;Nucleotides;particle;Pharmaceutical Chemistry;pharmacophore;Play;prevent;Process;protein aggregation;protein folding;Protein Import;Proteins;proteostasis;Research;Role;Saccharomyces cerevisiae;Solid;Specificity;Structure;System;Therapeutic;Time;tool;Toxic effect;Transportation;X-Ray Crystallography;Yeasts

PROJECT_TITLE: Structural and functional studies of Hsp70/Hsp110 molecular chaperones

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(02)M]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Health Services;Infectious Diseases;Lung;Microbiome;Precision Medicine;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: This application seeks to develop broad scanning medical diagnostic method for the detection of numerous pathogenic viruses and bacterial while characterizing microbiome of oral fluids. This diagnostic approach will improve healthcare by enabling early detection and more detailed profiling of both pathogenic and commensal microorganisms from human body fluids.

PI_NAMEs: TIMPERMAN, AARON T (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: 2019-nCoV;Amino Acid Sequence;Analytical Chemistry;ancestry analysis;Bacteria;Biological;Biological Assay;Biological Markers;Biomedical Engineering;Body Fluids;Bronchoalveolar Lavage Fluid;Clinical;clinical diagnosis;clinical diagnostics;clinically relevant;communicable disease diagnosis;Communicable Diseases;computerized data processing;Coronavirus;COVID-19 detection;Custom;Data;data acquisition;Databases;design;Detection;detection limit;detection method;Development;Diagnostic;diagnostic screening;diagnostic strategy;diagnostic value;Disease;disease diagnosis;Early Diagnosis;Engineering;Family;Goals;Health;Healthcare;Human;Human body;Immune system;improved;improved outcome;Infection;Injections;innovation;Ions;Label;Liquid substance;mass spectrometer;Mass Spectrum Analysis;Measures;Medicine;metaproteomics;Methods;Microbe;microbial;Microbiology;microbiome;Microfluidics;microorganism;Modeling;Molds;Monitor;oral microbiome;Outcome;pandemic disease;pathogen;Pathogen detection;pathogenic bacteria;pathogenic virus;Pathogenicity;Pennsylvania;Peptides;Performance;Periodicals;personalized approach;personalized medicine;Phylogenetic Analysis;Preventive Medicine;Proteins;Proteome;Proteomics;Rapid diagnostics;Reporting;Research;Research Personnel;resident commensals;respiratory;Respiratory Disease;respiratory microbiome;response;Reverse Transcriptase Polymerase Chain Reaction;Ribosomal RNA;Saliva;saliva sample;Sampling;SARS-CoV-2 variant;Scanning;screening;specific biomarkers;Speed;Stable Isotope Labeling;System;Technology;Testing;Universities;Validation;Variant;variants of concern;Viral;viral detection;Viral Load result;Viral Proteins;virology;Virus;Work

PROJECT_TITLE: Development of a screening diagnostic for the detection of viruses and bacteria from body fluids that utilizes the unparalleled structural characterization of mass spectrometry

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Prevention;Regenerative Medicine;Transplantation;Wound Healing and Care

ORG_CITY: DURHAM

ORG_NAME: BIOAESTHETICS CORPORATION

ORG_STATE: NC

PHR: NARRATIVE BioAesthetics seeks to improve outcomes for patients with full-thickness burn wounds by creating a dermal acellular biologic graft with a biocompatible, biodegradable, tunable hydrogel-based drug delivery system that provides sustained, local release of therapeutic agents. Our novel approach simultaneously provides a natural, biologic scaffold for patient-mediated tissue regeneration while countering the onset of complications due to infection during the course of wound healing. This Phase II project focuses on advancing our R&D efforts in a porcine burn model.

PI_NAMEs: BLUM, JULIANA LYN (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Affect;Age;American;Animal Model;Animals;Anti-Infective Agents;Antibiotic Resistance;Antibiotics;Antigens;Autologous Transplantation;base;Biological;biomaterial compatibility;Burn injury;burn model;burn wound;Cause of Death;Cells;Cessation of life;Cicatrix;Clinical;Collagen;Colony-forming units;Complication;crosslink;Dermal;Drug Delivery Systems;drug release profile;efficacy evaluation;Elastin;Engraftment;Extracellular Matrix;Failure;falls;Family suidae;Female;Fibroblasts;Fibroins;gamma irradiation;Goals;Good Manufacturing Process;healing;health related quality of life;Hospitalization;Human;Hydrogels;Hypertrophic Cicatrix;Immune;improved;improved outcome;in vivo;Infection;Infection Control;Infection prevention;infection risk;innovation;Legal patent;Length of Stay;Liquid substance;Local Anti-Infective Agents;male;Mammalian Cell;manufacture;Measurement;mechanical properties;Mechanics;Mediating;Medical;Medical Care Costs;Medical Device;Mental Health;Methods;Microcirculation;minimal risk;Modeling;mortality;Necrosis;novel;novel strategies;Oral Administration;pathogen;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Phase;phase 1 study;physical conditioning;polyhexamethylene biguanide;Polymers;porcine model;Porosity;Preclinical Testing;Process;product development;Proteins;Pseudomonas aeruginosa;reconstruction;regenerative;research and development;Risk;Risk Reduction;scaffold;severe burns;sex;Silk;Site;Skin;skin burn;Skin graft;Specific qualifier value;standard of care;Sterility;Sterilization;Surgical incisions;System;Techniques;Testing;Therapeutic Agents;third degree burn;Tissue Donors;Tissue Grafts;tissue regeneration;Tissues;Toxic effect;wound;wound bed;wound closure;wound healing;Wound Infection

PROJECT_TITLE: PHMB-Impregnated Acellular Biologic Grafts for Treatment of Third-Degree Burns


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Sepsis is a leading cause of mortality and critical illness worldwide, with recognition that it may lead to a profound and sustained immunosuppression known as immune paralysis (IP). There is a critical need to understand the underlying pathophysiology of sepsis-induced IP, with evidence now emerging that fatty acids (FA) and their metabolites are important immune signaling molecules and regulators of cytokine release. The goal of this proposal is to characterize metabolic and protein biomarkers of sepsis-induced IP by quantifying FA metabolites in circulating leukocytes and evaluating the role of immune paralyzed response proteins in the plasma of septic IP patients, thus identifying modifiable pathways that may be targeted to improve clinical outcomes.

PI_NAMEs: TORRES, LISA KRISTINA (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Address;Admission activity;adverse outcome;Agonist;Anti-Inflammatory Agents;Antibodies;Binding;biobank;Biological;Biological Assay;Biological Markers;Biology;biomarker identification;Body Fluids;candidate marker;candidate validation;career;Carnitine;Catabolism;CD14 gene;Cell Line;Cells;Cellular Metabolic Process;Cessation of life;Characteristics;Clinical;Clinical Pathways;Clinical Trials;clinically relevant;cohort;Collection;Complex;Critical Illness;Critical Pathways;cytokine;Data;design;Disease;Energy Metabolism;Energy Metabolism Pathway;Enrollment;Enzyme-Linked Immunosorbent Assay;Evaluation;Exhibits;experience;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Functional disorder;Future;Glycolysis;Goals;high risk;HLA-DR Antigens;Hospitals;Hour;Immune;immune activation;Immune response;Immune signaling;Immune Targeting;Immune Tolerance;Immunoassay;immunosuppressed;Immunosuppression;Impairment;improved;Inflammation;Influentials;Intervention;K-Series Research Career Programs;Label;Leukocytes;Link;Long-Term Effects;Measures;Mediating;Mediation;Mediator;Mentors;Metabolic;Metabolic dysfunction;Metabolism;metabolomics;Methods;Mitochondria;Molecular Epidemiology;monocyte;Morbidity - disease rate;mortality;multidisciplinary;Observational Study;opportunistic pathogen;Outcome;Oxidative Phosphorylation;Paralysed;Pathogenesis;Pathologic;Pathway interactions;Patient Recruitments;Patient-Focused Outcomes;Patients;Performance;Peripheral Blood Mononuclear Cell;pharmacologic;Plasma;Play;Predisposition;prospective;protein biomarkers;Proteins;Proteomics;recruit;Research;Research Design;Research Personnel;response;Role;secondary infection;Secondary to;Sepsis;septic;septic patients;Serum;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;Signaling Protein;skills;Specimen;Statistical Data Interpretation;Structure;success;Supportive care;Surrogate Markers;Testing;Therapeutic Intervention;Training;Translational Research;Vial device;Whole Blood

PROJECT_TITLE: Cellular and Metabolic Dysfunction in Sepsis-Induced Immune Paralysis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Data Science;Heart Disease;Heart Disease - Coronary Heart Disease;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention;Sleep Research

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Despite epidemiologic data consistently identifying sleep disruption and sleep disorders as a cardiovascular (CV) risk, rigorous investigation of the inclusion of these parameters in current CV risk prediction models has yet to be performed. We plan to leverage artificial intelligence modeling from a clinic-based cohort of >186,000 multimodal cardiorespiratory and neurologic physiologic signals from sleep studies database to investigate whether sleep-specific phenotypic represent independent risk factors for major adverse cardiovascular events and enhance the standard atherosclerotic cardiovascular disease (ASCVD) calculator. Data generated has high potential to be transformative in terms of informing CV risk stratification and design of sleep-specific CV clinical trials, setting the stage for external validation, and providing a basis to effectively harness the rich information contained in the >1.1 million polysomnograms performed annually in the United States.

PI_NAMEs: LIMA DINIZ ARAUJO, MATHEUS  (contact);MEHRA, REENA

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Address;American;American Heart Association;Apnea;Archives;Arousal;Arrhythmia;Artificial Intelligence;artificial intelligence model;Atherosclerosis;biobank;Biological Markers;Carbon Dioxide;Cardiology;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cessation of life;Clinic;Clinical;Clinical Trials;Clinical Trials Design;clinically relevant;cohort;college;Complex;computer science;Coronary heart disease;cost;Data;Data Set;Databases;deep learning;deep learning model;design;Dimensions;Drowsiness;Electrocardiogram;Electroencephalography;epidemiologic data;Equation;Event;experience;Functional disorder;Geography;Hypnogram;Hypoxia;Incidence;indexing;Individual;innovation;Investigation;large datasets;Life;limb movement;Machine Learning;machine learning model;Medicine;Methods;multimodality;Myocardial Infarction;National Heart, Lung, and Blood Institute;Neurologic;Obstructive Sleep Apnea;Oxygen;Pathway interactions;Pattern;Performance;Periodicals;Phenotype;Physiological;Positioning Attribute;pre-trained transformer;Registries;Research;Resources;Risk;Risk Factors;risk prediction;risk prediction model;risk stratification;Science;Signal Transduction;Sleep;Sleep Architecture;Sleep Disorders;Sleep disturbances;Snoring;Stroke;structured data;Sympathetic Nervous System;Testing;Time;Training;United States;Validation;Work

PROJECT_TITLE: Applying Innovative Artificial Intelligence Approaches to a Large Sleep Physiologic Biorepository to Integrate Sleep Disruption in Cardiovascular Risk Calculation

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_DEPT: NEUROLOGY

PHR: Overall Project Narrative: The Center for Improving Care Delivery for the Aging (CICADA) is a Resource Center for Minority Aging Research (RCMAR) at the University of Pennsylvania (Penn). CICADA aims to train emerging scientists from underrepresented backgrounds in the interdisciplinary science of HSR as it applies to the most pressing issues for aging Americans, particularly minority elders.

PI_NAMEs: LANE-FALL, MEGHAN BROOKS;WERNER, RACHEL M;WILLIS, ALLISON  (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Adult;Age;Aging;American;Black race;care delivery;career;career development;Caring;Clinical;cost;data resource;Dedications;Development;econometrics;Economics;education research;Elderly;Environment;Equity;equity, diversity, and inclusion;ethnic disparity;evidence base;Evidence based intervention;Evidence based treatment;experience;field study;Fostering;Funding;Future;Goals;Health;health care delivery;health economics;health equity;health inequalities;Health Sciences;Health Services Research;Healthcare;Healthcare Systems;Hispanic;Historically Black Colleges and Universities;implementation science;improved;Inequity;Infrastructure;Investigation;Leadership;leadership development;Learning;Medical Errors;medical schools;Mentors;Mentorship;Methods;Minority;Minority Groups;minority investigator;minority scientist;next generation;older adult;Pennsylvania;Personal Satisfaction;Pilot Projects;Politics;Population;programs;Quality of Care;racial determinant;racial disparity;recruit;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Support;Resources;routine practice;Schools;Science;Scientist;Services;skill acquisition;social culture;Structure;success;Training;Underrepresented Populations;Universities;uptake


NIH_SPENDING_CATS: Aging;Clinical Research;Health Services

PI_NAMEs: WERNER, RACHEL M (contact)

PROJECT_TERMS: Achievement;Adult;Aging;care delivery;career;Communication;Community Services;Country;Decision Making;Dedications;design;Development;education research;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;Faculty;Fostering;Funding;Future;Goals;Health;health care delivery;health economics;health equity;Health Services Research;Healthcare;Historically Black Colleges and Universities;improved;Infrastructure;Institution;Leadership;medical schools;meetings;Mentors;Minority;Minority Groups;minority scientist;Mission;Monitor;older adult;Pennsylvania;Personal Satisfaction;Policies;Population;Process;Quality of Care;recruit;Research;Research Methodology;Research Personnel;Resources;Science;Scientist;Structure;success;Talents;Time;Training;Translations;Underrepresented Populations;Universities;Work

PROJECT_TITLE: Center for Improving Care Delivery for the Aging (CICADA)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Services

PI_NAMEs: COE, NORMA B (contact)

PROJECT_TERMS: Address;Aging;American;care delivery;career;Communities;Complex;Consultations;contextual factors;Data;Data Collection;data resource;Data Set;Dedications;design;econometrics;education research;Environment;Equity;Familiarity;Fostering;Foundations;Genetic Transcription;Goals;Health;health care delivery;health economics;Health Services;Health Services Needs;Health Services Research;Healthcare Systems;implementation science;improved;Infrastructure;insight;Knowledge;Mentors;Mentorship;Methodology;Methods;Minority;Minority Groups;minority scientist;Mission;multidisciplinary;Nature;older adult;Patients;Personal Satisfaction;personalized approach;Population;Productivity;recruit;Research;Research Infrastructure;Research Methodology;Research Personnel;research to practice;Resources;Science;Scientist;Secure;Services;skill acquisition;skills;Solid;System;Talents;Training;Training and Infrastructure;Translating;Underrepresented Populations;Voice


PI_NAMEs: NAYLOR, MARY D (contact)

PROJECT_TERMS: Academia;Aging;Area;care delivery;career;career development;Caring;Categories;Clinical;Communities;design;Discipline;Doctor of Philosophy;education research;Eligibility Determination;Equity;equity, diversity, and inclusion;experience;Faculty;Fostering;Funding;Future;Goals;graduate student;Grant;health care cost/financing;Health Priorities;Health Services;Health Services Research;Healthcare;improved;Individual;instructor;interest;Lead;member;Mentors;Mentorship;Minority;Minority Graduate Student;Minority Groups;minority scientist;next generation;outreach program;Pilot Projects;Policy Maker;Population;Postdoctoral Fellow;Productivity;professor;programs;Publications;Recording of previous events;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Project Summaries;Research Training;Residencies;Role;Scientist;skills;Societies;Structure;Training;Translating;undergraduate student;Underrepresented Populations;Work;Writing


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Nutrition

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: Project Narrative The role of peroxisomes in promoting metabolic flexibility and longevity is poorly understood. This proposal will identify novel contributions of peroxisomal remodeling, regulation, and metabolism in promoting metabolic adaptation during fasting, which can be targeted to improve metabolic flexibility and increase longevity.

PI_NAMEs: SHARMA, ARPIT  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Acute;Address;Age;age related;age related changes;age related decline;Aging;Animals;anti aging;Area;Biology;Caenorhabditis elegans;Complex;Confocal Microscopy;Data;Dietary Intervention;dietary restriction;Fasting;fatty acid oxidation;feeding;flexibility;Goals;Health;healthy aging;improved;Intermittent fasting;Intervention;Knowledge;Link;lipid metabolism;Lipids;Lipolysis;Longevity;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;mitochondrial dysfunction;Morphology;novel;Organelles;Outcome;oxidation;Pathway interactions;peroxisome;Phase;Play;programs;Protein Import;Regulation;Research;response;Role;Shapes;Signal Transduction;Surface;Testing;therapeutic target;Tissues;Transcript;transcriptomics;Tubular formation;Work

PROJECT_TITLE: Targeting Mechanisms of Organelle Remodeling to Promote Healthy Aging

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Bioengineering;Biotechnology;Osteoarthritis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: Boulder

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proposed research is expected to improve integrative cartilage repair strategies. We will conduct studies to understand the response of human adult stem cells to biomaterials made from human-derived extracellular matrix, which are used for delivery and treatment of osteochondral damage. We will additionally establish cGMP processes that enable manufacturing of these cartilage and bone products, which will position us to advance commercialization efforts for musculoskeletal health.

PI_NAMEs: NEU, COREY P (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Address;Adhesions;Adoption;adult stem cell;Allografting;Animals;arthropathies;articular cartilage;Biocompatible Materials;Biological;Biological Assay;Biological Products;bone;Bone Injury;Bromodeoxyuridine;Cartilage;Cartilage injury;cartilage repair;Cell Count;Cell Differentiation process;cell motility;Cell Proliferation;Cells;Chemistry;Clinical Trials;Colorado;commercialization;Community Medicine;crosslink;Defect;Degenerative polyarthritis;density;Development;Devices;differential expression;Disease Progression;Embryo;Ensure;Equipment;Extracellular Matrix;Family suidae;fetal;Formulation;Friction;Future;Gene set enrichment analysis;Genes;Goat;Good Manufacturing Process;Grant;Guidelines;healing;Health;Human;human adult stem cell;Human Resources;human stem cells;human tissue;Hyaluronic Acid;Implant;improved;Individual;innovation;interstitial;Lubrication;macromolecule;manufacture;Marketing;Measures;mechanical properties;Mechanics;Medical;Mesenchymal Stem Cells;Muscle;Musculoskeletal;Natural regeneration;novel;Ontology;Operative Surgical Procedures;osteochondral repair;osteochondral tissue;particle;Particle Size;Pathway interactions;Persons;Phenotype;Positioning Attribute;pre-clinical;Process;Production;Property;Quality Control;Records;Regenerative Medicine;repair strategy;Reporting;Reproducibility;Research;response;Shapes;Signaling Molecule;Skin;Source;Specific qualifier value;Standardization;stem cell differentiation;stem cell proliferation;stem cells;Structure;Structure-Activity Relationship;Sulfhydryl Compounds;Surface;Technology;technology platform;Temperature;Testing;Tissue Therapy;Tissues;Toxic effect;transcriptome sequencing;Translations;United States;Validation;Work

PROJECT_TITLE: Development and Translation of Granulated Human-Derived Biomaterials for Integrative Cartilage Repair


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Social Determinants of Health

ORG_NAME: AMERICAN ASSOCIATION FOR CANCER RESEARCH

PHR: Public Health This project is a pivotal initiative by the American Association for Cancer Research since racial and ethnic minorities remain underrepresented as faculty in the field of cancer research. It is imperative to continue to increase the diversity and visibility of faculty members in the field. One of the most important aims of this award program is to facilitate networking and collaboration opportunities for minority faculty and faculty at Minority-Serving Institutions with the wide range of cancer researchers throughout the world. This is not just a necessity for minority faculty, but also essential for faculty at minority-serving institutions. Beyond the direct benefits to Scholar Awardees, the program has potentially wider implications for the health status of the minority population in general, resulting from the formation of a larger pool of experienced minority basic cancer researchers and clinicians to contribute, thrive, and gain health equity in the field. The enhancement of the MSI faculty member’s research program enriches the experience of the minority students he or she trains. Additionally, minority investigators are more likely to explore the issues relating to minority health disparities, as well as to have a better prospect of recruiting and collaborating with minority study subjects, and a significant increase in the number and visibility of minority cancer researchers might serve as an effective antidote to attitudes of distrust on the part of study participants and help lead to greater trust on the part of minorities in the medical and research institutions.

PI_NAMEs: FOTI, MARGARET  (contact)

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Alaska Native;American Association of Cancer Research;anti-cancer research;Antidotes;Area;Attitude;Award;Awareness;Caliber;Cancer Science;career;Clinical;Collaborations;COVID-19 impact;Development;distrust;Economics;ethnic minority;Exhibits;expectation;experience;Exposure to;Faculty;Funding;Funding Mechanisms;Future;Goals;Grant;Growth;Health Disparities Research;health equity;health inequalities;Health Status;Hispanic-serving Institution;Historically Black Colleges and Universities;innovation;Institution;interest;International;Knowledge;knowledge base;Laboratories;Lead;Malignant Neoplasms;Medical;meetings;member;Minority;Minority Groups;minority health disparity;minority investigator;minority student;Minority-Serving Institution;National Cancer Institute;Native Hawaiian;next generation;Outcome;Participant;peer;professor;programs;Public Health;Publications;Race;racial minority;recruit;Research;Research Personnel;Resources;Science;skills;social;Students;Study Subject;symposium;Time;Training;Travel;tribal college;Trust;Underrepresented Minority

PROJECT_TITLE: Minority and Minority Serving Institution Faculty in the Field of Cancer Research


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Screening and Brief Intervention for Substance Misuse;Substance Misuse;Telehealth;Underage Drinking

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Co-use of alcohol and cannabis (using both substances, either simultaneously or concurrently) represents a significant public health concern among young adults (YAs), as co-use is common and can exacerbate negative use-related outcomes, and existing interventions produce small effects. Romantic relationships are important and developmentally-salient influences on YA substance use and represent a potential intervention area that could increase engagement and maximize effects; despite this, there is a paucity of research on the extent to which romantic relationships impact alcohol and cannabis co-use behaviors or intervention outcomes among YAs. The present study seeks to significantly expand our understanding of alcohol and cannabis co- use in the context of YA romantic relationships through collecting daily dyadic quantitative data and qualitative interviews and using this information to develop and pilot an integrated brief intervention to decrease alcohol and cannabis misuse and increase healthy relationships skills among this understudied, high-risk group.

PI_NAMEs: WALUKEVICH-DIENST, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: acceptability and feasibility;Aggressive behavior;alcohol abuse therapy;Alcohol consumption;Alcohols;Area;Behavior;brief alcohol intervention;brief intervention;Cannabis;career;cohort;Communities;comparison control;Conflict (Psychology);Couples;Data;Data Analyses;Development;Ecological momentary assessment;Educational process of instructing;efficacy testing;Etiology;experience;feasibility testing;follow-up;high risk;high risk population;improved;Individual;innovation;Intervention;intervention delivery;intervention refinement;Interview;intimate behavior;Knowledge;Learning;Maintenance;marijuana use;Mental Health Services;Mentorship;Methods;mHealth;Modeling;multilevel analysis;National Institute on Alcohol Abuse and Alcoholism;novel;online intervention;Outcome;Participant;patient engagement;Pattern;Persons;Phase;Population;preservation;Prevention;Protocols documentation;prototype;Public Health;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Risk;satisfaction;Self Efficacy;sex;skills;social;social influence;social stigma;Source;substance misuse;substance use;Surveys;Testing;Time;Training;Treatment Efficacy;Treatment outcome;trial design;user centered design;young adult

PROJECT_TITLE: Developing and Testing an Online Intervention for Decreasing Alcohol and Cannabis Misuse and Increasing Healthy Relationship Skills among Young Adult Couples: A Comprehensive Mixed-Methods Approach

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Hematology;Orphan Drug;Pain Research;Rare Diseases;Sickle Cell Disease

ORG_NAME: ILLEXCOR THERAPEUTICS, LLC

PHR: Sickle cell disease (SCD), which results from a genetic mutation that allows hemoglobin (Hb) to self-assemble into rigid polymers that cause red blood cells (RBCs) to become malformed (“sickled”), affects approximately 100,000 Americans (and millions worldwide). Our scientific team has spent nearly three decades developing novel drugs that can block Hb polymerization, and consequently, RBC sickling, and our next generation drug candidates are groundbreaking because they have the potential to profoundly modify the natural history of the disease state and transform SCD into a manageable condition. Our team plans to advance two bona fide lead drug candidates into a robust and definitive panel of pre-clinical studies to demonstrate the extraordinary potential of these leads and to select one final lead candidate for human clinical trials.

PI_NAMEs: LIGHT, DAVID RICHARD (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Acute;Affect;Affinity;Aldehydes;American;Anemia;Animals;Anoxia;Antisickling Agents;Biological Availability;Biotin;Blood;Blood drug level result;candidate selection;Cessation of life;Chronic;clinical efficacy;Clinical Trials;Complex;Data;Development;Disease;disease natural history;Distress;DNA Sequence Alteration;Dorsal;Dosage Forms;Dose;drinking water;drug candidate;efficacy evaluation;efficacy study;Emulsions;Erythrocytes;Exposure to;Female;Fetal Hemoglobin;Food;Formulation;Foundations;Genus Vanilla;Goals;Half-Life;Health Care Costs;Hemoglobin;hemoglobin polymer;Hemolysis;Hemorrhage;Hepatotoxicity;Histopathology;Hour;Human;hydroxyurea;Hypoxia;Implant;improved;in vivo;Individual;inflammatory marker;innovation;insight;Interruption;intravital microscopy;Kinetics;Lateral;Lead;lead candidate;lead optimization;male;malformation;manufacturing scale-up;Measures;mouse model;Mus;next generation;novel;novel therapeutics;Oral;Oral Administration;Organ;Organ failure;Oxygen;Pain;Patients;Pharmaceutical Preparations;Phase;Plasma;polymerization;Polymers;pre-IND studies;preclinical study;premature;Prevention;Property;Recovery;Residual Neoplasm;Reticulocyte count;Rodent;safety study;Scientist;screening;self assembly;Sickle Cell;Sickle Cell Anemia;Sickle Hemoglobin;sickling;Skin;Solid;Structure;Study models;Suspensions;Testing;Therapeutic;Time;Toxic effect;Toxicology;vanillin;Whole Blood;Work

PROJECT_TITLE: Rapid Development of a Lead Aromatic Aldehyde Derivative with both Oxygen Dependent and Novel, Oxygen Independent Anti-Sickling Effects: Building on a Paradigm Shift in Sickle Cell Disease Therapy


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative  The public health relevance of this study relates to the persistent problem of undernutrition among very preterm infants, those born prior to 32 weeks of gestation. The proposed study will examine how the neonatal intensive care unit (NICU) diet and patterns of growth during the hospitalization contribute to, or protect against, the development of excess adiposity and cardiometabolic risk during early childhood (ages 2 and 5 years). Results from this study will inform new and more effective strategies for nutritional support, assessment, and monitoring of very preterm infants. The overall goal is for pragmatic, diet-based interventions during a sensitive period in development that support optimal long-term health for the ~63,000 very preterm infants born each year in the U.S. and many more worldwide.

PI_NAMEs: BELFORT, MANDY BROWN (contact);PERNG, WEI

PROGRAM_OFFICER_NAME: WALKER, JENELLE ROSE

PROJECT_TERMS: 2 year old;5 year old;Acceleration;Address;adiponectin;Age;American Heart Association;Biological Markers;Biometry;Birth;blood pressure reduction;Brain;C-reactive protein;Cardiology;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cardiovascular health;Child;Childhood;Chronic;Clinical;clinical care;Clinical Trials;cohort;Collaborations;Conceptions;Data;design;Development;Developmental Process;Diabetes Mellitus;Diet;dietary;Discipline of obstetrics;Disease;early childhood;Endocrinology;Energy Intake;Ensure;Exhibits;experience;extreme prematurity;Fatty acid glycerol esters;Fetal Development;Fetus;follow-up;Fortification;Future;Glucose;Goals;Growth;Health;Hospitalization;Hospitals;Human Milk;Hypertension;Impairment;improved;Individual;Infant;infant nutrition;infant outcome;innovation;Insulin;Intake;Intervention;Intervention Trial;Leptin;Life;Life course epidemiology;Lipids;Macronutrients Nutrition;Malnutrition;Measures;meetings;Metabolic syndrome;metabolomics;modifiable risk;Monitor;Morbidity - disease rate;neonatal care;Neonatal Intensive Care Units;Neonatology;neurodevelopment;Nutrient;Nutritional Support;Obesity;obesity risk;obstetric care;Outcome;Participant;Pattern;Physiology;point of care;Population;postnatal;Pregnancy;Premature Infant;Preventive;protein intake;Proteins;public health relevance;Randomized, Controlled Trials;Recommendation;Recording of previous events;Research;Risk Factors;Serum;standard of care;Survivors;targeted delivery;Testing;theories;Third Pregnancy Trimester;Visit;Vulnerable Populations;Weight Gain;Work;young adult

PROJECT_TITLE: Infant diet and cardiometabolic risk among children born preterm

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Biotechnology

ORG_DEPT: BIOLOGY

PHR: NARRATIVE The Nuclear Pore Complex (NPC) is a large megadalton cellular assembly composed of ∼550 proteins, that degrades structurally and compositionally with age, causing severe difficulties with cellular processes. The elusive ultrastructural and compositional degradation of NPC and their building components will be imaged using a combination of cryo-Focused Ion Beam milling-Electron Tomography (cryo-FIB-ET) and single-molecule imaging. With training from diverse group of mentors/advisors, this proposal will lay the groundwork for a new research program that will use these cutting-edge imaging modalities to map important ultrastructural/compositional cellular alterations caused by aging.

PI_NAMEs: SINGH, DIGVIJAY  (contact)

PROJECT_TERMS: Advisory Committees;Affect;Age;age related;age related changes;age related decline;aged;Aging;aging related;Architecture;Award;Bacteriophage T4;Biochemistry;career;Cell Aging;Cell Physiology;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;Cryoelectron Microscopy;Cytoplasm;data integration;Deterioration;Development;Disease;Doctor of Philosophy;Electron Beam Tomography;electron tomography;Environment;Enzymes;Foundations;Frequencies;Functional disorder;Gene Expression Regulation;Goals;Health;Image;imaging modality;Imaging Techniques;Immobilization;improved;In Situ;in situ imaging;In Vitro;Investigation;Ions;Leadership;Link;Maps;Mentors;Mentorship;Modality;Modeling;Molecular;molecular assembly/self assembly;molecular imaging;molecular modeling;Morbidity - disease rate;Motor;Nerve Degeneration;Neurons;novel;Nuclear;Nuclear Envelope;Nuclear Pore Complex;nucleocytoplasmic transport;Nucleoplasm;Organism;Paper;particle;Phase;Photobleaching;Play;Postdoctoral Fellow;Process;programs;Protein Isoforms;Proteins;Publications;reconstitution;Reporting;Research;Resolution;Sampling;Science;single molecule;skills;stoichiometry;structural biology;Structure;synthetic biology;Techniques;Therapeutic;Time;trafficking;Training;Transcriptional Regulation;Work;yeast genetics;Yeasts

PROJECT_TITLE: In situ imaging of the aging-induced structural and stoichiometric degradation of the nuclear pore complex and nuclear periphery


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Maternal Health;Pediatric;Substance Misuse;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

PHR: PROJECT NARRATIVE This advanced research education program concentrates on a uniquely vulnerable population— pregnant people who abuse substances and their babies who suffer from drug withdrawal and is responsive to PAR-21- 320. “Forefronts in Substance Abuse Disorders during Pregnancy, Postpartum, and Pediatrics (FrSADP3)” requests its first renewal within NIDA’s Research Education Program and the primary rationale is that there are too few underrepresented minority (URM) clinicians and clinical researchers, too few clinical and research programs investigating substance use (SU) and abuse (SA), and especially, substance abuse disorders (SAD) during pregnancy, postpartum, and pediatrics (P3) as well as there being far too few new URM trainees for clinical and clinical research careers within the SADP3 fields. By continuing to educate and mentor clinical researchers and clinicians, especially graduate, medical, dental, nursing, and other advanced students as well as postdoctoral fellows from under-represented minorities exclusively at minority serving institutions, this program will help to advance the research careers of the most promising clinical scientists and clinicians, with sensitivity to ensuring full diversity in the NIDA workforce.

PI_NAMEs: SCHATTEN, GERALD  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Address;Advocate;Animals;Birth;career;Career Choice;Career Mobility;Child;Clinical;Clinical Research;Collaborations;Color;Communities;Dental;design;Development Plans;Discipline of Nursing;Disease;Doctor of Pharmacy;Doctor of Philosophy;drug withdrawal;Education;education research;Educational process of instructing;Ensure;Environment;ethical, legal, and social implication;Evaluation;experience;Faculty;Fostering;Future;Goals;Health Insurance Portability and Accountability Act;healthy lifestyle;Hispanic-serving Institution;IACUC;Indigenous American;Individual;Inequity;innovation;insight;Institutional Review Boards;Investments;Laws;Leadership;lectures;Medical;member;Mentors;Methods;minority trainee;Minority-Serving Institution;National Institute of Drug Abuse;neonate;Participant;Pediatrics;peer;Persons;Pharmaceutical Preparations;Postdoctoral Fellow;Postpartum Period;Pregnancy;pregnant;programs;Psychologist;Qualifying;Reproducibility;Research;Research Personnel;Research Training;Resources;responsible research conduct;Risk;Safety;Scientist;Self Administration;skill acquisition;Students;Substance abuse problem;substance use;Supreme Court Decisions;Therapeutic;Toddler;Training;translational approach;Underrepresented Minority;United States National Institutes of Health;Universities;Vulnerable Populations;Women's Health

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Neurosciences;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed study is distinctive, innovative, and relevant to public health in light of the limited knowledge of sleep deficiency and its relationship to the social and physical environment during incarceration and after release from a correctional facility. The project is relevant to NHLBI’s mission-driven strategic goals to address sleep health disparities, given the disproportionate incarceration of racial and ethnic minoritized groups. This work aims to understand how incarceration uniquely affects sleep health at the individual, environmental and institutional levels, which can become the foundation of future work to decrease sleep and CVD morbidity and mortality for NIH disparity populations.

PI_NAMEs: ELUMN, JOHANNA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: actigraphy;Address;Administrator;Affect;Air;Arizona;Behavioral;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;chronic pain;circadian;Data;Deficiency Diseases;design;Development;Disparity;Disparity population;Environment;environmental disparity;Environmental Health;Environmental Policy;Environmental Risk Factor;ethnic minority population;Event;Exposure to;extreme temperature;Foundations;Future;General Population;Goals;Halfway Houses;Health;health determinants;health disparity;Housing;Hypertension;Imprisonment;improvement on sleep;Individual;Infrastructure;innovation;Institution;Institutional Policy;instrument;Intervention;Interview;Jail;Justice;Knowledge;Light;Maps;Measures;Medicine;Methodology;Methods;Minority Groups;Mission;Mood Disorders;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Nightmare;Noise;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;Persons;Physical environment;Pittsburgh Sleep Quality Index;Policies;poor sleep;Population;Positioning Attribute;Post-Traumatic Stress Disorders;Prisons;programs;Psychosocial Stress;Public Health;public health intervention;racial minority population;Recording of previous events;Reporting;Research;Research Personnel;Risk Factors;Role;Security;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep health;sleep quality;Sleeplessness;Social Environment;Social Sciences;Temperature;therapy development;Training;United States National Institutes of Health;Universities;violence exposure;Work

PROJECT_TITLE: Incarceration, Sleep Health, and Cardiovascular Disease Risk


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE Transcatheter arterial embolization using calibrated microsphere technology represents a remarkably successful chapter in minimally invasive interventions to treat various conditions ranging from arteriovenous malformations to hypervascular tumors. Although several types of embolic microspheres have been FDA authorized, clinicians have no technology for estimating the trajectory of emboli and as such significant uncertainty exists in embolization. To address the aforementioned issues, we propose to develop a two-way interactive biomaterial- computational platform to generate effective injection map, while also providing physicians insight into success rate for both informed and randomized injection in different vasculature for personalized embolization.

PI_NAMEs: ARZANI, AMIRHOSSEIN ;HU, JINGJIE  (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: 3D Print;Accounting;Address;Aneurysm;Animal Model;Animals;Arterial Embolization;Arteriovenous malformation;Authorization documentation;Behavior;behavior prediction;Biocompatible Materials;Biomedical Engineering;Blood;Blood flow;blood vessel occlusion;Blood Vessels;calginat;Calibration;Catheters;Charge;Chemicals;Clinical;clinical practice;clinically relevant;computational platform;Computational Technique;Decision Making;Degenerative polyarthritis;design;Development;Disease;Embolism;Ensure;Evaluation;experience;fabrication;Face;Family;Family suidae;Feedback;Fibroid Tumor;Foundations;Friction;Gastrointestinal Hemorrhage;Gelatin;Geometry;Hemorrhage;Hydrophobicity;Hypervascular;improved;In Vitro;in vivo;in vivo evaluation;individual patient;individualized medicine;Injections;injured;innovation;innovative technologies;insight;Intervention;Interventional radiology;Investigation;Ischemia;Life;Liquid substance;Liver;Liver neoplasms;Location;malformation;manufacturing process;Maps;Marketing;mechanical properties;Mechanics;Medical;meter;microsphere delivery;Microspheres;minimally invasive;Modeling;Morphology;Movement;next generation;North Carolina;Oils;Outcome;particle;Particle Size;Patients;Penetration;Performance;personalized medicine;physical model;physical property;Physicians;Physiological;Pilot Projects;Positioning Attribute;Procedures;Process;Production;Property;Prostatic hypertrophy;Randomized;rational design;Recurrence;Reporting;Resistance;Risk;Roentgen Rays;Safety;Shapes;simulation;Stroke;success;Surface;Techniques;Technology;Testing;Therapeutic;Therapeutic Embolization;Time;Tissues;Translations;Transportation;treatment planning;tumor;Uncertainty;Universities;Utah;Vascular Diseases;Visualization;Work

PROJECT_TITLE: Integrated experimental and computational approach for accurate patient-specific vascular embolization


NIH_SPENDING_CATS: Clinical Research;Hematology;Orphan Drug;Precision Medicine;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE (PUBLIC RELEVANCE) Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative therapy for many inherited and malignant diseases whose applicability has been impeded by the development of one of its most serious complication, chronic graft versus host disease (cGVHD). Unfortunately, there is no blood test for predicting response to cGVHD therapies. Strategies that identify and validate predictive biomarkers of cGVHD response to treatment will allow for personalized therapies that will be more efficient if introduced early in the course of the disease in many patients with hematological cancers.

PI_NAMEs: PACZESNY, SOPHIE  (contact)

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: Academia;Acute Graft Versus Host Disease;Address;Adopted;Aftercare;Allogenic;Antibody Affinity;Award;Biological;Biological Assay;Biological Markers;Biology;biomarker panel;Blood;Blood specimen;Blood Tests;Bone Marrow Transplantation;candidate identification;candidate marker;chemokine;chronic graft versus host disease;Clinical;Clinical Trials Network;clinically relevant;cohort;Collaborations;Complex;Complication;curative treatments;CXCL10 gene;Data;Dependence;Development;Disease;Disease Pathway;Disease Resistance;disorder risk;Enzyme-Linked Immunosorbent Assay;experience;experimental study;Exposure to;Future;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;In complete remission;Individual;Inherited;inhibitor;Interleukins;IRAK1 gene;JAK2 gene;kinase inhibitor;Lead;Ligands;Macrophage Colony-Stimulating Factor Receptor;Malignant - descriptor;Measures;Monitor;mortality;novel;novel therapeutic intervention;partial response;Pathology;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;personalized medicine;Pharmaceutical Preparations;Phase I/II Trial;Phosphotransferases;Plasma;Plasma Proteins;predicting response;predictive marker;predictive panel;Prognosis;prognostic;prognostic value;Progressive Disease;Proteins;proteomic signature;Proteomics;receptor;Refractory;Research;Resistance;response;Risk;Risk Marker;risk stratification;Sampling;secondary endpoint;Sensitivity and Specificity;specific biomarkers;Specificity;Steroids;Stromelysin 1;success;tandem mass spectrometry;Testing;Therapeutic;therapy resistant;Time;Transplant Recipients;treatment response;Validation

PROJECT_TITLE: Chronic Graft-Versus-Host Disease Biomarkers: Prediction of Resistance to Therapy

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Racial and ethnic disparities impact end-of-life care in nursing homes, including the use of hospice, a government benefit program that provides end-of-life services delivered by an interdisciplinary specialist team. Although hospice decreases illness burden and improves quality of life, there is little information on why it is not used more frequently. By analyzing large national nursing home datasets and examining qualitative data, our study will address this gap and provide evidence needed to promote equitable access to hospice in nursing homes nationwide.

PI_NAMEs: DHINGRA, LARA K;DICK, ANDREW WYLIE;STONE, PATRICIA W. (contact)

PROGRAM_OFFICER_NAME: AKUBU-ODERO, MAUREEN KALAMBU

PROJECT_TERMS: Address;Administrator;Adult;advanced disease;Alaska Native;American;American Indians;Asian;Black race;burden of illness;Caring;Categories;Cessation of life;Country;COVID-19;COVID-19 impact;COVID-19 pandemic;Critical Care;Data;Data Set;decubitus ulcer;Delirium;Disparity;disparity reduction;Elderly;Emergency department visit;end of life;end of life care;end of life outcomes;Enrollment;Equity;ethnic difference;ethnic disparity;ethnic minority;Ethnic Origin;evidence base;Family;Family Caregiver;Government;Health;health disparity;Hispanic;Hospice Care;hospice environment;hospice utilization;Hospitalization;human old age (65+);implicit bias;improved;Inequity;Inpatients;insight;Institutional Racism;Interview;Knowledge;Life;Life Expectancy;Location;Long-Term Care;Measures;Medicare;Methods;minority health;minority health disparity;Modeling;mortality;National Institute on Minority Health and Health Disparities;Native Hawaiian or Other Pacific Islander;Not Hispanic or Latino;Nursing Homes;nursing skill;older adult;Outcome;outcome disparities;Pain;pandemic disease;pandemic impact;Patients;Policies;Process;Professional Education;programs;Quality Indicator;Quality of Care;Quality of life;Race;racial difference;racial disparity;racial minority;Recommendation;Research;Sampling;Services;sex as a biological variable;Specialist;Structural Racism;Structure;Symptom Burden;Time;Visit;Visiting Nurse

PROJECT_TITLE: Health Disparities in Hospice in Nursing Homes

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Although the United States has a stated goal of reducing new HIV infections by 90% over ten years, efforts are hampered by lack of information on where undiagnosed cases are to be found. Wastewater (sewage) surveillance is proving to be an exciting new public health tool for identifying communities where infectious diseases are circulating. We propose to test the feasibility of detecting HIV in human waste and in wastewater as first steps in establishing a surveillance system that can enhance HIV prevention and control.

PI_NAMEs: PARSONNET, JULIE  (contact)

PROGRAM_OFFICER_NAME: SHARP, GERALD B

PROJECT_TERMS: 2019-nCoV;Affect;AIDS prevention;authority;Biological Assay;California;Caring;Clinical;Communicable Diseases;Communities;community transmission;Complement;cost effective;County;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;digital;Disease;Disease Surveillance;DNA;Ensure;feasibility testing;Feces;Goals;Health;high risk;HIV;HIV diagnosis;HIV Infections;HIV Seropositivity;HIV-1;HIV/AIDS;Hospitalization;Human;Human immunodeficiency virus test;improved;in vitro Assay;Incidence;Individual;Infection;infection risk;interest;Knowledge;Measurement;Measures;Medical;Methods;Modeling;Monitor;Monkeypox;National Institute of Allergy and Infectious Disease;novel;Nucleic Acids;Outcome;pandemic disease;pathogen;Pathogen detection;Patient Care;Persons;Plasma;Poliomyelitis;Population;Prevalence;prevent;prevention service;Public Health;rate of change;recruit;Reduce health disparities;Reporting;research study;Resource Allocation;response;Reverse Transcriptase Polymerase Chain Reaction;Reverse Transcription;Risk Assessment;RNA;sample archive;Sampling;San Francisco;screening;screening services;Services;Sewage;Solid;Specimen;stool sample;success;Surveillance Methods;System;Testing;Time;time use;tool;transmission process;treatment services;trend;Uncertainty;United States;Urine;Viral;Viral Load result;Viremia;Virus;Visit;wastewater epidemiology;wastewater samples;wastewater surveillance;wasting;Work

PROJECT_TITLE: Feasibility of conducting HIV surveillance in community wastewater

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE—RELEVANCE TO HEALTH  Bystander cardiopulmonary resuscitation (B-CPR) is the most effective treatment for out-of-hospital cardiac arrest (OHCA); however, the likelihood of receiving B-CPR and surviving OHCA varies significantly based on neighborhood demographics. Our research is designed to identify modifiable barriers to B-CPR participation in at-risk neighborhoods, and adapt a targeted, culturally sensitive, community-level intervention designed to improve B-CPR participation and OHCA survival in underserved populations.

PI_NAMEs: COUTE, RYAN ANDREW (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Alabama;American Heart Association;Automated External Defibrillator;Award;Awareness;Blood flow;Brain;Cardiopulmonary Resuscitation;career development;Caring;Cause of Death;Censuses;Communities;community intervention;Data;Death Rate;Deep South;demographics;design;Development Plans;disability;Education;effective therapy;Emergency medical service;Emergency response;Event;experience;Feedback;first responder;Focus Groups;Funding;Future;Goals;Grant;Group Interviews;Health;Heart;Heart Arrest;high risk;Human Resources;implementation science;improved;Incidence;innovation;insight;Institute of Medicine (U.S.);Interruption;Intervention;Interview;Knowledge;Lead;Learning;Life;Literature;Location;low socioeconomic status;Maps;member;Mentored Patient-Oriented Research Career Development Award;Mentorship;Minority Groups;multi-site trial;multidisciplinary;Neighborhoods;novel;Organ;out-of-hospital cardiac arrest;Outcome;outcome disparities;patient oriented;Patient Self-Report;Population Heterogeneity;prototype;Qualitative Methods;Qualitative Research;Race;Reporting;Research;Research Personnel;Resuscitation;Risk;Science;Self Assessment;social health determinants;socioeconomic disparity;Socioeconomic Status;socioeconomics;Structure;support network;Survival Rate;survivorship;Testing;Therapeutic;therapy design;Time;Training;treatment and outcome;Underserved Population;United States;usability;Variant;willingness

PROJECT_TITLE: Improving Community-level Bystander Cardiopulmonary Resuscitation in Underserved Populations

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Limited evidence has operationalized how disinvestment or disenfranchisement —salient manifestations of structural racism— plausibly raise AD/ADRD risk via cardiovascular disease (CVD). The proposed research ultimately aims to simulate multilevel policies that reduce Black/White disparities in AD/ADRD.

PI_NAMEs: SIMS, KENDRA D (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Acceleration;Adult;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Area;Award;beneficiary;Black Populations;Black race;black/white disparity;Blood Vessels;burden of illness;California;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular effects;Censuses;Characteristics;Clinical;cohort;Collaborations;Communities;community empowerment;Community Surveys;community-level factor;County;cultural competence;Data;Data Science;dementia risk;demographics;Depressed mood;Deterioration;Development;Disparity;disparity reduction;Economic Factors;economic indicator;Economics;empowerment;Ensure;Event;Exclusion;Faculty;Foundations;Future;Goals;Health and Retirement Study;Health Care Costs;Health Policy;Housing;Incidence;Infrastructure;innovation;Institution;Intervention;Investments;Joints;Knowledge;Lead;Link;Low income;Machine Learning;marginalization;Mediating;Mediator;Medicare;Medicare claim;Mentors;Mentorship;Minority;Modeling;mortality;neighborhood disadvantage;Neighborhoods;older adult;Pattern;Phase;Policies;policy implication;Political Factor;Politics;Population;Population Attributable Risks;Positioning Attribute;Prevalence;prevent;Prevention;Public Health;Public Policy;Race;racial disparity;Racial Segregation;Reasons for Geographic And Racial Differences in Stroke;Relative Risks;Research;Research Personnel;residence;Resources;Risk;Risk Estimate;Risk Factors;Role;Sampling;San Francisco;scale up;Science;segregation;skills;Social Environment;socioeconomics;Stroke Belt;Structural Racism;success;Surveys;systemic barrier;Training;Translating;University resources;Variant

PROJECT_TITLE: Community Empowerment, Vascular Risk, and ADRD Disparities: Translating Research to Public Policy


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Nanotechnology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Colonic neoplasia, from adenoma to carcinoma exhibits “niche independence” where normal regulatory mechanisms involving Wnt signaling for cell proliferation are unchecked, resulting in tumors. Strategies to inhibit such signaling have not worked therapeutically, however, increasing Wnt signaling even further in tumors has a non-intuitive result where they end up ultimately inhibited. In contrast, normal colonic epithelium has improved growth with increased Wnt signaling. This proposal seeks to leverage this phenomenon to inhibit colon cancer but improve normal colon cell function, which may unlock a new paradigm of colon cancer treatment.

PI_NAMEs: ENG, GEORGE  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Adenocarcinoma;adenoma;Advisory Committees;Affect;Agonist;APC gene;APC mutation;Award;beta catenin;Biological Assay;Biomedical Engineering;Caliber;Cancer Biology;Cancer Model;Carcinoma;Cell Nucleus;Cell Physiology;Cell Proliferation;Cells;Clinical;clinical care;Colon;Colon Adenocarcinoma;colon cancer treatment;Colon Carcinoma;Colonic Adenoma;Colonic Neoplasms;Colorectal Cancer;Complex;CRISPR interference;Data;Dependence;Development Plans;Diet;Dose;Elements;Engineering;Ensure;Epithelium;Essential Genes;Exhibits;Foundations;Frequencies;gene editing technology;General Hospitals;Genes;Genetic;Glycogen Synthase Kinase 3;Growth;Human;human model;improved;in vivo;inhibitor;Institution;Intestines;knock-down;Knock-out;KRAS2 gene;Lesion;Location;loss of function;loss of function mutation;Loss of Heterozygosity;Maintenance;Malignant Neoplasms;Massachusetts;Medical;Mentors;Modeling;Moderna COVID-19 vaccine;Molecular;mouse model;Mus;mutant;Mutate;Mutation;nanoparticle;nanoparticle delivery;neoplastic cell;Normal Cell;Normal tissue morphology;novel;Oncogenic;Organoids;Pathologist;Pathway interactions;Patients;pharmacologic;Physicians;Polypectomy;Pre-Clinical Model;progenitor;programs;Protein Kinase;Proteins;Recording of previous events;Research;Resources;Rho-associated kinase;Scientist;Signal Transduction;small molecule inhibitor;Specimen;stem cells;Stereotyping;success;targeted treatment;Technology;Therapeutic;Time;Toxic effect;TP53 gene;Training;transcriptome sequencing;transcriptomics;tumor;tumor growth;Wnt proteins;WNT Signaling Pathway;Work

PROJECT_TITLE: Differential Wnt Dependencies in Colon Epithelium.

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Lung;Neonatal Respiratory Distress;Osteogenesis Imperfecta;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Patients with skeletal dysplasias, including osteogenesis imperfecta (OI), often suffer from congenital respiratory problems that have limited therapeutic opportunities, and increase perinatal and early childhood mortality. With the long-term goal of identifying novel therapeutic approaches to treat the respiratory disease and prevent morbidity and mortality in OI, the specific goals of this proposal are to dissect the contribution of intrinsic lung defects versus extrinsic skeletal defects to impaired lung functions in OI; and to unravel cellular and molecular mechanisms triggered by type I collagen defects leading to abnormal lung development and impaired respiratory function. Collectively, our studies will lead to a better understanding of lung pathogenesis in OI and other skeletal dysplasias, and the role of the extracellular matrix during alveolar formation.

PI_NAMEs: MORELLO, ROY  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;Age Months;AGTR2 gene;Alveolar;Alveolar Cell;alveolar epithelium;Biological Assay;bone fragility;Bronchopulmonary Dysplasia;Cell Communication;Cell Culture Techniques;Cells;Chest wall structure;COL1A1 gene;COL1A2 gene;Collagen;Collagen Diseases;Collagen Type I;Defect;Deformity;Deposition;Development;Disease;dominant genetic mutation;Dysplasia;early childhood;Epithelial Cells;Exhibits;Extracellular Matrix;Fibroblasts;Fibrosis;Functional disorder;Future;Gene Expression;gene function;Genes;Genotype;Glycine;Goals;Health Care Costs;Hospitalization;Impairment;In Situ;In Vitro;in vivo;insight;Knock-in Mouse;Lateral;loss of function;LoxP-flanked allele;Lung;lung development;lung histology;Measurement;Mesenchymal;Messenger RNA;meter;Molecular;Morbidity - disease rate;Morphogenesis;morphometry;mortality;mouse model;Mus;Mutation;Myofibroblast;Neonatal Respiratory Distress;novel;novel therapeutic intervention;Organoids;Osteogenesis Imperfecta;Pathogenesis;Pathway interactions;Patients;Pattern;Perinatal;Phenotype;Positioning Attribute;Post-Translational Protein Processing;prevent;Production;Proteins;pulmonary function;Pulmonary Pathology;Resolution;respiratory;Respiratory Disease;Respiratory Mechanics;Respiratory physiology;Role;Secondary to;self-renewal;skeletal;skeletal dysplasia;Skeleton;Spinal Curvatures;Structure;Testing;Therapeutic;Tissues;transcriptome;transcriptomics;Work

PROJECT_TITLE: Lung developmental defects caused by type I collagen mutations in mouse models of osteogenesis imperfecta

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: MADISON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Narrative: This project aims to develop efficient and robust methods for the design and analysis of cardiovascular (CV) clinical trials with complex composite endpoints that combine patient mortality with lesser events like hospitalization. Specifically, it addresses the nonparametric estimation of effect size (overall and subgroup-wise), sample size calculation under both fixed and adaptive designs, semiparametric regression, and risk prediction. The new methods will not only help improve the analyses of recent CV trials like INVESTED, but also in the long run helps to shift the paradigm towards fuller and more meaningful utilization of patient data.

PI_NAMEs: MAO, LU  (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Accounting;Address;Archives;Biological Markers;Cardiopulmonary;Cardiovascular system;Cessation of life;Characteristics;Chest Pain;classification trees;Clinical Trials;Complex;conditioning;Congestive Heart Failure;cost;Data;design;Development;Event;experience;flexibility;follow-up;Future;Goals;Grant;Health;Heart failure;Hospitalization;improved;indexing;influenza virus vaccine;Investigation;life history;Machine Learning;markov model;Measures;member;Methodological Studies;Methodology;Methods;Modeling;Modernization;mortality;Myocardial Infarction;novel;Outcome;Patients;predictive modeling;predictive tools;Probability;random forest;Randomized;Recording of previous events;Recurrence;Research Design;Research Personnel;response;Risk Assessment;Risk Factors;risk prediction;Sample Size;secondary analysis;semiparametric;Severities;Statistical Methods;statistics;Stroke;Subgroup;Techniques;Testing;theories;Time;Time trend;tool;treatment effect;Trees;trial design;user-friendly;Work

PROJECT_TITLE: Novel Statistical Methods for Complex Time-to-Event Data in Cardiovascular Clinical Trials


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Lung;Patient Safety;Prevention;Rare Diseases

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Acute respiratory distress syndrome (ARDS) is a common form of severe lung injury that occurred in 10% of pre- pandemic ICU admissions, results in mortality of 30-45%, and has become a leading cause of death from COVID- 19. This multicenter randomized controlled trial evaluates whether a novel ventilation strategy that individualizes support to minimize lung stress, compared to guided usual care, improves survival and pulmonary recovery in ventilator-dependent patients with ARDS. Results from this trial may establish a personalized approach to ARDS management that reduces morbidity and mortality and, by extension, decreases costs and strain on the healthcare system.

PI_NAMEs: BAEDORF KASSIS, ELIAS  (contact);HOULE, TIMOTHY T

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Address;Admission activity;Adult;Adverse event;Applications Grants;arm;atelectrauma;Attenuated;Automobile Driving;Biological Markers;Body Weight;Breathing;Case Report Form;Cause of Death;Clinical;Clinical Trials Data Monitoring Committees;Collaborations;Communication;community engagement;Consent;cost;COVID-19 mortality;COVID-19 pandemic;Critical Illness;Data;Data Collection;Data Coordinating Center;data management;Data Set;design;efficacy testing;electronic data capture system;Electronics;Enrollment;Ensure;evidence base;expiration;Feedback;Fostering;Funding Agency;Goals;Grant;Healthcare Systems;hemodynamics;high risk;high standard;improved;Infrastructure;Injury;innovation;Instruction;Intervention;Investigation;Laboratories;Lung;lung injury;lung pressure;Maintenance;Manuscripts;Measurement;Measures;Mechanical ventilation;meetings;Methodology;Monitor;Morbidity - disease rate;mortality;Newsletter;novel;Outcome;Participant;patient oriented;patient safety;Patients;personalized approach;personalized strategies;Phase;Physiological;Population;Positive-Pressure Respiration;pre-pandemic;Preparation;pressure;prevent;Prevention strategy;primary outcome;prospective;Protocol Compliance;protocol development;Protocols documentation;Quality Control;randomized trial;Randomized, Controlled Trials;Recording of previous events;Recovery;Reporting;Reproducibility;Research;Research Personnel;respiratory;Respiratory Mechanics;Risk;safety assessment;Shock;Site;standard care;standard of care;statistical center;Stress;support tools;symposium;Techniques;Teleconferences;Testing;Tidal Volume;Time;Titrations;treatment arm;treatment as usual;trial planning;usual care arm;ventilation;Ventilator;Ventilator-induced lung injury;web site

PROJECT_TITLE: 2/2: PREcision VENTilation to attenuate Ventilation-Induced Lung Injury (PREVENT VILI)

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Prevention;Women's Health Research

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Over 40,000 women die every year from aggressive therapy-resistant metastatic breast cancer. In  this application, we will use animal models and patient samples to define how necrosis helps breast  tumor cells mutate and spread to distant organs and spread to distant organs and determine whether preventing necrosis can block development of therapy resistance and tumor evolution.

PI_NAMEs: CHEUNG, KEVIN JON (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Adjuvant;Adjuvant Therapy;Aftercare;Aggressive behavior;aggressive therapy;Aneuploidy;Angiopoietins;Animal Model;Antineoplastic Agents;barrier to testing;Benefits and Risks;Biological Availability;Biological Models;Blood;Blood flow;Blood specimen;Blood Vessels;Breast Cancer Cell;Breast Cancer Detection;breast cancer metastasis;Breast Cancer Patient;Breast Cancer therapy;cancer recurrence;cancer subtypes;cancer therapy;Cell Death;Cells;Cessation of life;Chemoresistance;chemotherapy;Clinical;clinical prognostic;cohort;Complex;Data;Development;Disease;Dissection;Distant;DNA analysis;driving force;Drug Delivery Systems;drug development;Drug resistance;Ecosystem;Epidemiologist;Evolution;Family;Generations;Genes;Genome;genomic signature;Genomics;Hand;Heterogeneity;Histologic;Human;Hypoxia;Impairment;improved;Individual;innovation;knock-down;liquid biopsy;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;member;Metastatic breast cancer;Metastatic Neoplasm to the Lung;Modeling;Molecular;molecular marker;mouse model;Mus;Mutate;Mutation;Necrosis;Necrosis Induction;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;Nutrient;Organ;Outcome;Oxygen;patient derived xenograft model;Patients;Penetration;Perfusion;Pharmaceutical Preparations;Phenotype;population based;Population Study;prevent;Prevention;Primary Neoplasm;prognostic;Prognostic Marker;prognostication;programs;Protein Secretion;Rattus;Recurrence;Residual Cancers;Resistance;response;Risk;Risk Factors;risk prediction;Risk Reduction;Role;Sampling;Source;synergism;Testing;Therapeutic;therapeutic development;therapy development;therapy resistant;Tissue Sample;Tissues;Toxic effect;trait;tumor;tumor DNA;tumor growth;tumor heterogeneity;Tumor-Derived;Woman;women's diagnosis;Work

PROJECT_TITLE: Role of necrosis in the evolution of highly metastatic and chemo-resistant breast cancers

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


PHR: PUBLIC HEALTH NARRATIVE The goal of the Longevity, Equity, and Aging Research Network (L.E.A.R.N) Consortium RCMAR is to advance the health and wellbeing of diverse older Americans by (a) facilitating multi-institutional, trans-disciplinary, collaborative ethnogeriatrics health disparities research that integrates biological, social, behavioral, and cultural aspects using various innovative research methods and (b) diversifying the future workforce in aging research.

PI_NAMEs: PERIYAKOIL, VYJEYANTHI S (contact);YESAVAGE, JEROME A

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Aging;Alaska Native;Alzheimer's disease related dementia;American;American Indians;Area;Behavioral;behavioral and social science;Behavioral Sciences;Big Data;biobehavior;Biological;Biological Sciences;Biology;biomedical data science;career;Collaborations;Color;Communities;community partners;computer science;Cultural Backgrounds;Data Science;Demography;Development;digital health;disorder risk;Disparity;disparity reduction;Economics;education research;Elements;Ensure;Environment;Epidemiology;Equity;ethnic minority population;experience;Family health status;Federally Qualified Health Center;forging;Fostering;Funding;Future;Genetic Markers;Goals;Health;Health Disparities Research;health disparity;Health Services Research;Health Status;Healthcare;Healthcare Systems;Hispanic-serving Institution;improved;Individual;Infrastructure;innovation;Institution;Intervention;Laboratories;Leadership;Longevity;Low income;Measures;Mentors;Methodology;Minority;minority health;Minority-Serving Institution;Mission;novel;older adult;Older Population;Pacific Islander;Performance;Personal Satisfaction;Physical environment;Pilot Projects;Policies;Population Heterogeneity;precision medicine;programs;Psychiatry;psychologic;Psychology;psychosocial;Public Health;Recording of previous events;recruit;Reduce health disparities;Registered nurse;Research;research and development;Research Infrastructure;Research Methodology;Research Personnel;research to practice;Resources;San Francisco;Science;Scientist;simulation;social;social culture;social media;social science research;Social Sciences;Strategic Planning;Training;Translational Research;Underrepresented Populations;Universities;Vertebral column;virtual reality;virtual reality simulation;Work

PROJECT_TITLE: Longevity, Equity, and Aging Research Network (L.E.A.R.N.) Consortium


NIH_SPENDING_CATS: Aging;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: PERIYAKOIL, VYJEYANTHI S (contact)

PROJECT_TERMS: Advisory Committees;Aging;Award;Behavioral;Biological;biomedical data science;Biometry;Collaborations;Communication;Communities;community partners;Data;Department chair;design;digital health;Discipline;Ensure;Equity;Evaluation;Evaluation Research;evidence base;Fostering;Funding;Goals;Health;Health Disparities Research;health disparity;Healthcare;Healthcare Systems;human subject;implementation research;implementation science;improved;Individual;Infrastructure;infrastructure development;innovation;Institution;Institutional Review Boards;Intervention;Knowledge;laurencin;Leadership;Longevity;Medical;Medicine;meetings;member;Mentors;Methodology;Methods;Minority;Minority-Serving Institution;Monitor;Occupational activity of managing finances;older adult;Persons;Pilot Projects;precision medicine;Procedures;Process;Productivity;professor;programs;Psychiatry;Qualitative Research;recruit;Registered nurse;Regulation;Research;research and development;Research Methodology;Safety;Scientist;Site;social;synergism;System;Teacher Professional Development;Techniques;United States National Institutes of Health;Universities;virtual reality;virtual reality simulation

PROJECT_TITLE: Longevity, Equity, and Aging Research Network (L.E.A.R.N.) Consortium Leadership & Administrative Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_DEPT: VETERINARY SCIENCES

PHR: Project Narrative The central nervous system control of whole-body metabolism has been an appealing area to develop interventions against obesity and related metabolic disorders. Results from the proposed studies will establish an anatomic and mechanistic link between the ventromedial hypothalamus, body weight control, and metabolic homeostasis. It will provide insights into novel therapeutics to treat obesity with limited adverse effects.

PI_NAMEs: YANG, XIAOYONG  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acute;Adipose tissue;Adverse effects;Affect;Anatomy;Area;Biological Process;Blood;Blood Glucose;Body Weight;Brain;brain circuitry;cell type;Central Nervous System;comorbidity;detection of nutrient;Development;Diabetes Mellitus;Diet;Electrophysiology (science);energy balance;Enzymes;Excision;Exhibits;Exposure to;Fatty acid glycerol esters;gain of function;Gender;Genetic;glucagon-like peptide 1;Goals;High Fat Diet;hindbrain;Homeostasis;Hormonal;Hormones;Hypothalamic structure;Impairment;in vivo;Injections;insight;Insulin;Intervention;Leptin;Link;lipid metabolism;Lipolysis;Literature;loss of function;Maps;Mediating;Metabolic;Metabolic Diseases;Metabolism;Modeling;Modification;Molecular;Molecular Profiling;molecular targeted therapies;Mus;nerve supply;Nervous System control;neural;neural circuit;neuronal excitability;Neurons;neuroregulation;new therapeutic target;novel therapeutics;Nutrient;Nutritional;O-GlcNAc transferase;Obesity;obesity treatment;optogenetics;Pathway interactions;peptide O-linked N-acetylglucosamine-beta-N-acetylglucosaminidase;Peripheral;pharmacologic;Phenotype;Physiological;Physiology;Play;Post-Translational Protein Processing;Property;Proteome;Public Health;receptor;Regulation;Research;response;ribosome profiling;Role;sensor;Sensory;sex;sexual dimorphism;Signal Transduction;Stream;Sympathetic Nervous System;Testing;Tissues;tool;Viral;Weight Gain;Weight maintenance regimen

PROJECT_TITLE: Body weight control by hypothalamic OGT

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-L(02)M]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ZOU, JAMES  (contact)

PROJECT_TERMS: Aging;Behavior Therapy;Behavioral;Big Data;biobehavior;Bioinformatics;Biological;biomedical data science;Biometry;career;Caring;Clinical;Collaborations;Communities;comparative effectiveness;Data;Database Management Systems;Databases;design;digital health;Disparity;Education;education research;Educational process of instructing;Epidemiology;Equity;Evaluation Research;evidence base;Exercise;experience;Faculty;forging;Future;Goals;Guidelines;Health;health determinants;Health Disparities Research;health disparity;health outcome disparity;Health Status;Healthcare;Heterogeneity;Human;human subject;Immigrant;implementation research;implementation science;improved;Incubators;Individual;Individuals with physical disabilities;Infrastructure;innovation;Intervention;Joints;Lead;Leadership;Learning;Longevity;Mainstreaming;Medicine;Mental disability;Mentors;Methodology;Methods;Minority;minority communities;Minority Groups;Minority-Serving Institution;Modeling;Monitor;Multiple Partners;Nature;Occupational;older adult;Older Population;Peer Review;Persons;Pilot Projects;podcast;Policies;Population;Population Heterogeneity;precision medicine;Process;Productivity;programs;Psychiatry;psychologic;Publications;Publishing;Qualitative Research;Reduce health disparities;Refugees;Registered nurse;Reproducibility;Research;research and development;Research Design;Research Ethics;Research Methodology;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Science;Scientist;Sexual and Gender Minorities;Sister;social;social culture;social health determinants;Statistical Methods;statistics;Techniques;Training;Underrepresented Minority;Underrepresented Populations;Universities;virtual reality;virtual reality simulation;web site;Work

PROJECT_TITLE: Longevity, Equity, and Aging Research Network (L.E.A.R.N.) Consortium Analysis Core


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Hematology;Nutrition;Patient Safety;Pediatric;Prevention;Rehabilitation;Women's Health Research

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE Pediatric patients undergoing spinal fusion surgery for the correction of Adolescent Idiopathic Scoliosis are at high risk of both preexisting and surgery-related iron deficiency, yet the means and evidence for optimizing iron status have not been described in this setting. The proposed study is a randomized controlled trial of preoperative oral iron supplementation, to identify whether iron deficiency is a modifiable risk factor for adverse surgical outcomes such as red blood cell transfusion and diminished postoperative cognitive and physical capacity in this vulnerable population of adolescents. Building evidence for patient blood management interventions such as iron supplementation is vital to ensuring high quality care of surgical patients and may reduce unnecessary transfusions amid recent blood shortages.

PI_NAMEs: EISLER, LISA DANIELLE (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: Activities of Daily Living;Address;Adherence;Adolescent;Adult;Adverse effects;adverse outcome;Affect;aged;Anemia;Blood;Blood Transfusion;career;Caring;Child;Childhood;Clinical;Cognitive;cognitive capacity;Community Trial;Data;design;early childhood;efficacy evaluation;Ensure;Epidemiology;Erythrocyte Transfusion;Erythrocytes;evidence base;experience;Female Adolescents;Ferritin;follow-up;functional decline;functional outcomes;functional status;Future;Goals;Growth and Development function;Hematology;Hemoglobin;Hemorrhage;high risk;Idiopathic scoliosis;Impaired cognition;Impairment;improved;improved outcome;Incidence;Infection;Institution;Intervention;Iron;iron deficiency;iron supplementation;Link;Menstruation;Mentors;modifiable risk;Monitor;Muscle function;Neurocognition;Neurocognitive;neurocognitive test;Neurotransmitters;Nutritional;Operating Rooms;Operative Surgical Procedures;Oral;Outcome;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;pediatric patients;Pediatric Surgical Procedures;Perioperative;Persons;Physical Capacity;Physical Function;physical impairment;Physiological;Pilot Projects;Placebos;Population;Postoperative Period;Predisposition;Preoperative Care;prevent;Production;Protocols documentation;Quality of Care;Randomized;Randomized, Controlled Trials;Recovery;Recovery of Function;Regimen;Reporting;Research;Research Design;Research Personnel;Risk;Risk Factors;Role;scoliosis;Serum;Serum Markers;Signal Transduction;Spinal Fusion;Spine surgery;standard of care;Supplementation;surgery outcome;Surgical Blood Loss;Testing;Trace Elements;Training;Transfusion;United States National Institutes of Health;vulnerable adolescent;Vulnerable Populations;Work

PROJECT_TITLE: Efficacy of Preoperative Oral Iron Supplementation in Adolescents Undergoing Scoliosis Surgery