NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Regenerative Medicine;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE (unchanged from Parent R37) Plasticity is emerging as a crucial hallmark of advanced cancer, but the molecular mechanisms that enable dynamic cancer cell adaptation to the stresses of metastasis are not understood. We will leverage patient samples, organoids, and insights we have generated to define key epigenetic nodes that determine the emergence of regenerative plasticity in MetSCs, and define the phenotypic consequences of transcriptional reprogramming during metastatic outgrowth. Results will define mechanisms of cancer progression and identify putative therapeutic targets to limit regenerative plasticity, with the potential to impact clinical outcomes.

PI_NAMEs: GANESH, KARUNA  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: 3' Untranslated Regions;Adherens Junction;Advanced Malignant Neoplasm;Aggressive behavior;Automobile Driving;BFU-E;Binding;biobank;Biological;Biological Factors;Biological Models;Biology;black patient;Black Populations;Black race;cancer cell;cancer genetics;cancer genomics;Cancer Model;cancer stem cell;Caring;catalyst;Cell Cycle;Cells;Cessation of life;chemotherapy;Chromatin;Clinical;Clinical Data;Colitis;Colon;colon cancer patients;Colorectal Cancer;colorectal cancer progression;colorectal cancer treatment;Communities;Data;derepression;Development;Disparity;driver mutation;drug testing;E-Cadherin;Elements;Engineering;Epigenetic Process;Epithelial Cells;epithelial stem cell;Epithelium;ethnic disparity;Family;follow-up;Genes;Genetic;genetic signature;Genetic Transcription;Genomics;Genotype;Germ Lines;Goals;health care availability;Homeostasis;Impairment;improved;Incidence;insight;intestinal epithelium;Intestinal Neoplasms;Intestines;Invaded;KRAS2 gene;LGR5 gene;Lymphocyte;Maintenance;Malignant Neoplasms;Mediating;member;metastatic colorectal;Methods;Modeling;Molecular;mortality;mRNA Transcript Degradation;Mus;Muscle;Mutation;Natural regeneration;Neoplasm Metastasis;neoplastic;Neural Cell Adhesion Molecule L1;Neurons;Normal tissue morphology;Not Hispanic or Latino;novel;Obesity;Oncogenes;Organoids;Outcome;Parents;Patient-Focused Outcomes;Patients;Phenotype;Physiological;population health;Pre-Clinical Model;precision drugs;Prevalence;Primary Neoplasm;progenitor;Proliferating;prospective;Race;racial disparity;racial minority;regeneration potential;regenerative;regenerative cell;Regulation;repaired;Research;Resistance;response;restoration;Risk Factors;RNA-Binding Proteins;Role;Sampling;self-renewal;single-cell RNA sequencing;Smoking;socioeconomics;stem cell differentiation;stem cell self renewal;stem cells;stemness;Stress;Structure;Testing;therapeutic evaluation;therapeutic target;Time;tissue regeneration;Tissues;TP53 gene;transcriptional reprogramming;treatment guidelines;tumor;tumor behavior;tumor initiation;tumor progression;Tumor Tissue;Tumor-Derived;Work;wound healing;Xenograft procedure;ZFP36L2 gene

PROJECT_TITLE: Functional modeling of race-specific features underlying phenotypic reprogramming in metastatic stem cells from colorectal cancer patients


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Newark

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative Delaware INBRE build’s Delaware’s capacity to do biomedical research by supporting investigator driven research projects, undergraduate research training, student/faculty professional development and research infrastructure. This ensures that all Delawareans have access to the training needed to pursue biomedical research careers while discovering new knowledge that can be applied to improve the health of the Nation.

PI_NAMEs: DUNCAN, MELINDA K (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Automobile Driving;Bioinformatics;Biomedical Research;career;Center for Translational Science Activities;Centers of Research Excellence;Child Health;Classification;Collaborations;college;Communities;community college;computer infrastructure;computing resources;Core Facility;cost;Data;Data Science;Data Science Core;Data Set;data sharing;Delaware;Development;Educational Curriculum;Educational workshop;Ensure;Excision;experience;Faculty;faculty support;Fostering;Funding;Future;Generations;Goals;Grant;Health;health care service;Health Insurance Portability and Accountability Act;Health Sciences;Healthcare Systems;improved;Infrastructure;innovation;Institution;Institutional Policy;instrumentation;Internships;Investigation;investigator training;Investments;Knowledge;Laboratories;Logistics;Low income;Medical;Mentors;Methodology;Methods;Minority;Mission;multidisciplinary;new technology;next generation;operation;Pilot Projects;Policies;Principal Investigator;Program Evaluation;Program Research Project Grants;programs;Publishing Peer Reviews;Research;Research Activity;research faculty;Research Infrastructure;Research Peer Review;Research Personnel;Research Project Grants;Research Support;Research Training;Resource Sharing;Resources;Scholars Program;Scientist;Services;student mentoring;Students;success;synergism;System;Teacher Professional Development;tool;Training;Training and Education;undergraduate research;undergraduate student;underrepresented minority student;United States National Institutes of Health;Universities;voucher;Work;Writing

PROJECT_TITLE: Delaware INBRE


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative Genomes must be compacted and organized to fit within the confines of the cell but at the same time remain accessible so that information within the DNA can be read by enzymes that are responsible for expressing genes that determine cell identity. When the coordination between compaction and accessibility is disrupted, cancer and developmental disorders emerge. Here I will develop novel in vitro assays to directly investigate how genome compaction and accessibility are coordinated to regulate gene expression with the long-term goal of understanding how disease mutations disrupt this coupling.

PI_NAMEs: VOS, SEYCHELLE MONQIUE (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Adopted;Affect;Behavior;Biochemical;Biological Assay;Cell Nucleus;cell type;Cells;Chromatin;Complex;Coupled;Coupling;Cryoelectron Microscopy;Data;Developmental Delay Disorders;developmental disease;Diameter;Disease;DNA;DNA Sequence;Enzymes;Gene Expression;Genes;Genetic Transcription;Genome;genome integrity;Goals;Histones;Human;Human Genome;In Vitro;in vitro Assay;Intellectual functioning disability;Length;Link;Malignant Neoplasms;Measures;Mediating;meter;Methods;Molecular Machines;Mutation;novel;Nucleosomes;Output;Process;promoter;Proteins;Reaction;reconstitution;single molecule;Specificity;Testing;Time;time use;Transcription Elongation;transcription factor;Transcription Process;Tube

PROJECT_TITLE: Towards fully reconstituting mammalian transcription in a test tube


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pain Research;Patient Safety;Peripheral Neuropathy;Physical Rehabilitation;Rehabilitation;Women's Health Research

ORG_CITY: TUCSON

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative Carpal tunnel syndrome is a commonly diagnosed hand disorder routinely treated by surgery. We have discovered a novel, non-surgical method to enlarge the volume of the carpal tunnel space, decompress the median nerve, and alleviate symptoms such as pain and numbness/tingling in patients with carpal tunnel syndrome. This supplement project is to investigate and demonstrate the efficacy of our carpal arch space augmentation strategy in symptom relief and hand function improvement in Hispanic women afflicted with carpal tunnel syndrome.

PI_NAMEs: KWOH, C KENT;LI, ZONG-MING  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Area;Arizona;Biomechanics;Carpal Tunnel Syndrome;Diagnosis;Disease;Effectiveness;follow-up;Hand;hand rehabilitation;health care disparity;Hispanic Populations;Hispanic Women;Intervention;Laboratory Research;median nerve;Methods;Modality;Neuropathy;novel;Numbness;Operative Surgical Procedures;Outcome;Pain;Participant;Patients;Phase;Population;Prevalence;Randomized;reduce symptoms;Reporting;Research Design;standard of care;Surgical complication;surgical disparities;symptom treatment;Symptoms;Therapeutic;Treatment Efficacy

PROJECT_TITLE: Biomechanical treatment of carpal tunnel syndrome for Hispanic women


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: IRVINE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative The communication of cells over organismal-level distances and across difficult-to-surmount biological barriers is mediated by membrane-enclosed particles known as extracellular vesicles and constitutes one of the most important fundamental phenomena in biology. To date, surprisingly few technologies capable of controlling the formation, release, and delivery of extracellular vesicles have been developed, and these technologies possess significant technical limitations, inadequate key figures of merit, and lack viable paths to clinically-relevant applications. The proposed research seeks to develop a powerful and generalizable methodology for electrically controlling extracellular vesicle-mediated cell-cell communication and to leverage this methodology for guiding cell fate and directing tissue development in living animals.

PI_NAMEs: GORODETSKY, ALON A (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Animals;bioelectronics;Biological;Biology;Breathing;Cardiovascular system;Cell Communication;Cell Physiology;Cells;Cephalopoda;Clinical;clinical application;clinical diagnostics;clinically relevant;Communication;controlled release;Development;Devices;Disease;Engineering;extracellular vesicles;Foundations;Genetic;genetically modified cells;Human body;Implant;Length;Ligands;Lipids;Literature;Mediating;Membrane;Metabolic syndrome;Methodology;Musculoskeletal Diseases;Nerve Degeneration;novel diagnostics;Nucleic Acids;particle;Pathologic;Pathway interactions;Physiological Processes;Play;Production;programs;Proteins;Regulation;Research;Role;Signal Transduction;Skin;Source;Stimulus;Structure;System;Techniques;Technology;Therapeutic;Tissues;treatment strategy;tumor progression;Vesicle;wireless;Work;wound healing

PROJECT_TITLE: Cephalopod-Inspired Bioelectronic Control of Cellular Signaling


NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: Bacterial biofilms are the predominant lifestyle of bacteria in nature and they can also cause chronic infections that are difficulty to treat. This study aims to track the gene expression profile in each biofilm cell and to dissect the intricate interplay between single-cell gene expression, individual cell behavior, and local cell organization that underlies the developmental program of bacterial biofilms. Such an understanding is crucial for combatting biofilm-related problems and harnessing beneficial biofilms.

PI_NAMEs: YAN, JING  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;Antibiotic Therapy;Architecture;Bacteria;bacterial community;Biomechanics;cell behavior;Cells;Chemicals;chronic infection;Clinical;Complex;Coupled;deep learning algorithm;Development;Disease;Extracellular Matrix;Gene Expression;Gene Expression Profile;Genes;Growth;Health;Heterogeneity;Image;imaging platform;Individual;Industrialization;innovation;Knowledge;Life Style;live cell imaging;Methods;Microbial Biofilms;Motility;Nature;operation;Pattern;Population;Procedures;Production;programs;Regulation of Cell Shape;Reporter;Resolution;response;Shapes;Signal Transduction;spatiotemporal;Surface;Variant

PROJECT_TITLE: Tracking single-cell gene expression heterogeneity and its consequences in bacterial biofilms


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Human cells use signals called “RNA second messengers” to stimulate the immune response, control cancer, and guide correct tissue development. Surprisingly, our work has revealed that the best characterized gene known to activate RNA second messenger signaling is part of a broad family of signaling enzymes and many RNA second messenger pathways remain to be discovered. We have developed an innovative approach to uncover the function of these enzymes and provide a detailed understanding of how RNA second messengers can be harnessed to improve immune responses and prevent disease.

PI_NAMEs: KRANZUSCH, PHILIP J (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: analog;Area;Biology;Cancer Control;cancer type;Cells;Cellular biology;Cellular Stress;Chemicals;Communication;Cyclic GMP;Development;Disease;Enzymes;experimental study;Family;Fourier Analysis;Genes;Human;Human Biology;human disease;Immune;Immune response;Immunologic Stimulation;improved;Infection;innovation;Malignant Neoplasms;Molecular;Mutate;Names;Natural Immunity;Natural Products;nucleotidyltransferase;pathogen;Pathway interactions;Pharmaceutical Preparations;prevent;Proteomics;receptor;Research;response;RNA;Second Messenger Systems;Signal Pathway;Signal Transduction;Tissues;tumor;Work;X-Ray Crystallography

PROJECT_TITLE: Discovery of cGAS-like signaling enzymes in innate immunity and disease


NIH_SPENDING_CATS: Biotechnology;Networking and Information Technology R&D (NITRD)

ORG_CITY: EUGENE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative  A large portion of potential drug targets are inaccessible to the most widely used therapeutic modalities: small molecules and antibodies. Peptides are powerful alternatives for drugging these targets; however, their use has been hugely underexplored due to challenges in the way of obtaining cell-permeable peptides that can access intracellular targets. In this proposal, we use a novel data-driven approach that combines state-of-the-art computational techniques, such as peptide design and machine learning, with experimental data generation to develop methods and datasets that will pave the way for the development of next generation cell-permeable peptide therapeutics.

PI_NAMEs: HOSSEINZADEH, PARISA  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Address;Affinity;Antibodies;Artificial Membranes;Categories;Cell membrane;Cells;Computational algorithm;Computational Technique;Computing Methodologies;Data;Data Set;design;Development;Disease;drug discovery;Drug Targeting;Drug usage;falls;Generations;interdisciplinary approach;interest;Libraries;Machine Learning;Mammalian Cell;Methods;Modality;Modeling;Modification;next generation;novel;peptide drug;Peptides;Permeability;Pharmaceutical Preparations;Physics;rapid technique;Research Personnel;screening;small molecule;Surface;Testing;Therapeutic;therapeutic development;Therapeutic Uses;uptake;Work

PROJECT_TITLE: A data-driven approach towards generation of permeable peptide therapeutics


NIH_SPENDING_CATS: Natural Products

PHR: Project Narrative Chiral organic molecules play an essential role in the study and treatment of human disease. However, synthetic challenges limit access to these important bioactive compounds. This proposal describes a conceptually new approach to the selective formation – and revision – of stereogenic centers across a wide range of architecturally diverse molecular scaffolds. If successful, the research described here is anticipated to transform chemical synthesis and enable unprecedented access to diverse bioactive chiral molecules.

PI_NAMEs: WENDLANDT, ALISON  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: 3-Dimensional;Architecture;Chemical Structure;chemical synthesis;chiral molecule;Complex;drug candidate;Environment;epimerization;functional group;Goals;human disease;Hydrogen Bonding;Individual;man;Molecular;Natural Products;novel strategies;Pattern;Pharmaceutical Preparations;Play;Probability;programs;Research;Resources;Role;Route;scaffold;Time;tool;Toxic effect

PROJECT_TITLE: Late Stage Stereochemical Editing to Transform the Synthesis of Bioactive Molecules


NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The research proposed here will provide crucial insights into how individual cells of vertebrate animals, such as humans, differentiate into mature tissues. This work will promote better understanding of: (1) cellular principles underlying fate restriction in development, (2) the genetic basis for embryonic failures, birth defects, and developmental disorders, and (3) developmental mechanisms that impact how individual cells compete and interact in embryonic tissues. Overall, the proposed research will accelerate our understanding of error- correction processes that take place naturally in embryos, and will generate molecular predictions for how these processes might be one day harnessed or modulated in human patients.

PI_NAMEs: WAGNER, DANIEL E (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Acceleration;Address;Adult;assault;Behavior;Biological;Cell Fate Control;cell type;Cells;Cessation of life;Complex;Computational Biology;Conceptions;Congenital Abnormality;Defect;Development;Developmental Biology;developmental disease;Disease;Elements;Embryo;embryo tissue;Embryonic Development;experimental study;Face;Failure;Feedback;fitness;Genes;Genetic;Genetic Models;Genome;Growth;Health;Human;in vivo;Individual;insight;Laboratories;Life;Link;Maps;Measurement;Microfluidics;Modeling;Molecular;molecular decomposition;Molecular Genetics;Motivation;mutant;Patients;Pattern;Phenotype;Pregnancy;premature;Process;programs;Research;Resolution;single cell genomics;Spontaneous abortion;System;Testing;Tissues;transcriptome;vertebrate embryos;Vertebrates;Vision;Visit;whole genome;Work;Zebrafish

PROJECT_TITLE: Mapping cell fate flow and feedback control on vertebrate embryonic landscapes


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Understanding how proteins work and the interactions that they participate in is the bedrock of functional biology and drug development. Most protein interactions remain uncharacterized. By developing an entirely new approach to map protein contact sites, this proposal will revolutionize our understanding of these interactions and will provide a roadmap for future studies aimed at functionally charactering and pharmacologically manipulating the protein interactome.

PI_NAMEs: BACKUS, KERIANN MARIE (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TITLE: A systems-level approach to decipher the protein interactome.


NIH_SPENDING_CATS: Cancer

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Most cell death studies are focused on how cells die, while this study focuses on the cells that suffer from programmed necrosis but can survive. We hypothesize that the necrotic “survivors” can stimulate oncogenesis via chemokines/cytokines secretions. We will reveal the molecular mechanisms of the “necrotic survivors” and further target these “survivors” to improve cancer treatments.

PI_NAMEs: GONG, YI-NAN  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Animal Model;cancer therapy;Caspase;Cell Culture System;Cell Death;Cell membrane;Cells;chemokine;cytokine;Data;Electron Transport Complex III;Family member;genome-wide;Goals;Grant;Granzyme;Human;improved;innovation;Ion Channel;Lytic;Malignant Neoplasms;Membrane;Molecular;Names;Necrosis;Neoplasm Metastasis;paracrine;Phosphorylation;Process;repaired;Research;RIPK3 gene;Role;sensor;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Small Interfering RNA;Specimen;Survivors;Testing;Time;Transplantation;tumor;tumorigenesis;ubiquitin-protein ligase

PROJECT_TITLE: Necrotic survivors and plasma membrane integrity signaling


NIH_SPENDING_CATS: Biotechnology;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Receptors are specialized proteins in our bodies that we use to experience the world – from our sense of smell and taste to our perception of pain and our ability to learn new information. We do not possess the tools necessary to determine how and under what conditions each of the hundreds of unique receptors in our bodies promote health or disease. In this project I will apply a revolutionary new method I have developed in protein engineering to create the tools necessary to control these receptors and study how they make us who we are.

PI_NAMEs: ENGLISH, JUSTIN G. (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Biochemical;Biological Assay;Biological Process;Biomedical Research;Brain;cell type;Cells;Directed Molecular Evolution;Disease;Dopamine;Event;experience;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Health;Health Promotion;Hormones;Human;Human Genome;immune function;invention;Learning;Ligands;Methods;Modeling;Mus;Neurotransmitters;Output;pain perception;Physiological;Production;Protein Engineering;Protein Family;Proteins;receptor;Research;Rewards;Signal Transduction;Signaling Protein;Smell Perception;success;System;Taste Perception;tool;United States National Institutes of Health;Vision

PROJECT_TITLE: Directed Evolution of Cell-Type Specific On-Demand Signaling Control Systems


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DALLAS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative The genomic sequence directs its 3D organization and gene regulation which is essential for the normal development and function of the human body. Genome variations across individuals may disrupt structural and gene regulations and contribute to susceptibility to diseases and response to therapeutics, yet the consequences of genome variations are generally unknown. Computational models proposed in this project will decode the structural and transcriptional impact of any genome sequence and open up new possibilities in assessing the impacts of genome variants and understanding their roles in disease genetics.

PI_NAMEs: ZHOU, JIAN  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 3-Dimensional;Accounting;Affect;Architecture;Back;Base Pairing;Binding Proteins;Chromatin;chromatin protein;Complex;computational platform;computer framework;Computer Models;Data;deep learning;Dependence;Development;Disease;Enhancers;Gene Expression;Gene Expression Regulation;Genetic;Genetic Diseases;Genetic study;Genetic Transcription;Genome;Genomics;Human body;in silico;Individual;Modeling;multi-scale modeling;Mutagenesis;Nuclear;Output;Physical condensation;precision medicine;Predisposition;promoter;Regulation;response;Role;sequence learning;Structure;Techniques;Therapeutic;three-dimensional modeling;Transcriptional Regulation;Variant;Work

PROJECT_TITLE: Sequence models of genome regulatory architecture in 3D


ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE RNA splicing is an essential and typically accurate process that is responsible for generating mature messenger transcripts. However, many human diseases such as cancer are associated with disruptions to global splicing homeostasis and the underlying causes remain largely unknown. This proposal aims to examine the connection between epigenetics and splicing to uncover their relationship in both healthy and unhealthy contexts and identify new opportunities for therapeutic intervention.

PI_NAMEs: CHOI, PETER S. (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TITLE: Exploring hidden determinants of splicing with genome-targeted proximity labeling


ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE RNA (the transcriptome) is central in the flow of biological information from DNA to protein, while chemical modifications of RNA (the epitranscriptome) represent an additional layer of regulatory information to control cell state and fate. Existing methods can only profile mRNA modifications from mixtures of millions of cells, limiting our ability to understand mRNA modifications in tissues that are comprised of diverse cell types in various states. We propose to develop a new set of tools to enable transcriptome-wide profiling of mRNA modifications with single-cell and spatial resolutions, and further apply these new tools to reveal whether different cell types regulate RNA modifications differently and how gene regulation events in single cells collectively give rise to tissue function and dysfunction.

PI_NAMEs: WANG, XIAO  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Atlases;Biological;Biological Models;Brain;brain tissue;cell type;Cells;chemical fingerprinting;Chemicals;Code;Complex;complex biological systems;Disease;DNA;epitranscriptome;epitranscriptomics;Eukaryota;Event;Functional disorder;Gene Expression;Gene Expression Regulation;Health;Heterogeneity;human disease;In Situ;in situ sequencing;innovation;Measurement;Measures;Mediating;Messenger RNA;Methods;Modification;Morphology;Mus;Pathway interactions;Pattern;Post-Transcriptional Regulation;prevent;Proteins;Resolution;RNA;RNA analysis;Site;Tissues;tool;transcriptome;Work

PROJECT_TITLE: Single-cell in situ analysis of RNA modifications in intact tissues


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative Mononegaviruses are an order of negative sense single stranded RNA viruses that include a number of viruses important to global health. Despite their importance, the molecular machinery that drives their life cycles is challenging to study, especially within their native environments. We propose to study measles, rabies, and Ebola viruses under near native conditions, i.e. as intact virions or within infected cells, by developing new and innovate technical approaches.

PI_NAMEs: WAN, WILLIAM N (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Binding;Biochemical;Biological;Biological Preservation;Cells;Classification;Complex;Computing Methodologies;Cryo-electron tomography;Cryoelectron Microscopy;Data Collection;Disease;Ebola virus;Electron Microscopy;Environment;Event;Family;Genetic Transcription;Genome;global health;In Situ;Infrastructure;innovation;insight;Ions;Life Cycle Stages;light microscopy;Measles virus;Membrane;Messenger RNA;Methods;Molecular;monolayer;Mononegavirales;novel;particle;pathogen;Rabies virus;Research;Resolution;RNA;RNA Viruses;structural biology;Structure;Taxonomy;therapeutic target;Thinness;three-dimensional visualization;Viral;Virion;Virus;Virus Assembly

PROJECT_TITLE: Elucidating the mechanisms of viral life cycles under near-native conditions


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PHR: PROJECT NARRATIVE: Mammalian cell biology happens in 3 dimensions, but our most powerful tools (whole genome screening, single cell analysis) cannot access complex 3D biology. This program will develop a new approach that combines powerful functional genomics tools with 3D cell culture and advanced computational analysis, enabling us to gain deep insight into complex disease biology at scales that were previously impossible.

PI_NAMEs: NEAL, JAMES THOMAS (contact)

PROJECT_TERMS: 3-Dimensional;Biology;Biomedical Research;Cell Communication;cell type;Cells;Cellular biology;Complex;Computer Analysis;Disease;Dissociation;experimental study;functional genomics;genome-wide;genomic tools;Genomics;Growth;high dimensionality;Human;Human Biology;In Situ;insight;Mammalian Cell;Methods;Modeling;next generation;novel strategies;Optics;Organoids;Phenotype;phenotypic data;preservation;programs;Research Personnel;screening;single cell analysis;spatial relationship;Structure;Technology;three dimensional cell culture;Tissues;tool;two-dimensional;whole genome

PROJECT_TITLE: Optical Functional Genomics


NIH_SPENDING_CATS: Prevention

ORG_CITY: NEW YORK

ORG_STATE: NY

PHR: PROJECT NARRATIVE Clearance of apoptotic cells, termed ‘efferocytosis’, is thought to be essential for preventing autoimmunity and inflammatory disease, yet these illnesses rarely present with defects in ability to clear apoptotic cells. Here, we propose that autoimmunity and inflammatory disease arise because efferocytosis is inherently dangerous, and macrophages (the body’s primary phagocyte) require mechanisms to detect and respond to dangerous engulfed material. We will identify and characterize these mechanisms, termed rapid response circuits, that are used for ‘healthy’ efferocytosis, with the goal of developing a framework for understanding how failure to appropriately digest apoptotic cells contributes to autoimmunity and inflammatory disease.

PI_NAMEs: PERRY, JUSTIN S (contact)

PROJECT_TITLE: Rethinking the "quiet" nature of apoptotic cell clearance.


ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The living cell is composed of highly dynamic organelles, but the events occurring inside organelles at the intra-organelle level are still not well understood. Using advanced super-resolution microscopy, this proposal will provide new insights into intra-organelle events within organelles, such as the dynamics of mtDNA, mtRNA and mitochondrial chaperones inside the mitochondrial matrix, and shed light on how these dynamics inform mitochondrial and cellular function, neuronal homeostasis and the pathways underlying multiple mitochondrial diseases which have been linked to neurodegeneration. Elucidating the role and regulation of intra-organelle events will ultimately advance our understanding of the dynamic cellular architecture of the living cell and expand our fundamental knowledge of cellular homeostasis and neurodegenerative disease mechanisms.

PI_NAMEs: WONG, YVETTE  (contact)

PROJECT_TERMS: Architecture;Automobile Driving;Cell Physiology;Cells;Cellular biology;Defect;Disease;Etiology;Event;Genetic Transcription;Goals;Homeostasis;human disease;Individual;insight;Knowledge;Link;Maps;Membrane;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;Mitochondrial Matrix;Mitochondrial RNA;Molecular;Molecular Chaperones;Mutation;nanoscale;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurons;Neurosciences;novel;novel therapeutics;Organelles;Pathogenesis;Pathway interactions;Patients;Population;protein complex;Proteins;Proteome;Regulation;Role;single molecule;Site;Speed;superresolution microscopy;Time;Work

PROJECT_TITLE: The dynamic architecture of living cells: Uncovering intra-organelle events at nanoscale levels


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative  Injuries or diseases that lead to the loss of limbs or digits affect an estimated 2 million Americans, posing important unmet challenges to the medical community. The overall goal of this proposal is to study the cellular and molecular mechanisms that restore the complex biological composition and structure of the mouse digit tip after amputation injury and harness these mechanisms to promote limb regeneration in patients. To achieve this goal, we will use a novel mouse model and cell culture system to probe the function of genes and pathways that regulate limb development and develop a stem cell-based therapy to modulate the regrowth of amputated digits in mice.

PI_NAMEs: QU, FEINI  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Adult;Advisory Committees;Advocate;Affect;Alkaline Phosphatase;American;Amputation;Amputees;Animals;Basic Science;Bioinformatics;Biological;Biological Assay;blastema;BMP2 gene;BMP7 gene;bone;bone fracture repair;Bone Morphogenetic Proteins;Bone Tissue;Calcium;career;career development;Cell Culture System;Cell Lineage;Cell Shape;Cell Transplantation;Cells;Cellular Morphology;chromatin immunoprecipitation;Cicatrix;clinically relevant;Communities;Complex;Confocal Microscopy;Deposition;Development;Developmental Biology;digit regeneration;Digit structure;digital;Disease;Distal;Educational Activities;Embryo;Ensure;Environment;Eph Family Receptors;Ephrins;Feedback;Fluorescent in Situ Hybridization;foot;Fostering;Gene Cluster;Gene Expression;gene function;gene regulatory network;Generations;Genes;Genetic;genome editing;Goals;Growth;Hand;Histology;Homeobox Genes;Homeostasis;Human;Immunohistochemistry;improved;In Vitro;in vitro testing;in vivo;in vivo regeneration;induced pluripotent stem cell;Injury;innovation;Institution;lentiviral-mediated;Ligands;Limb Bud;Limb Development;limb loss;limb regeneration;Limb structure;LoxP-flanked allele;Measures;Mediating;Medical;Mentors;Methods;microCT;Minerals;Molecular;Monitor;Morphogenesis;mouse model;Mus;Musculoskeletal;musculoskeletal injury;Natural regeneration;novel;Osteoblasts;Osteogenesis;osteogenic;osteoprogenitor cell;overexpression;Pathway interactions;Patients;Pattern;Phosphorylation;Physical condensation;Positioning Attribute;Production;Prognosis;programs;Quality of life;regeneration potential;regenerative;regenerative biology;Regenerative capacity;Regenerative Medicine;Regulation;Regulator Genes;Regulatory Pathway;Research;research faculty;Research Personnel;Research Project Grants;Resources;RNA;Role;second harmonic;Series;Signal Pathway;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Site;skeletal;skeletal regeneration;skeletogenesis;Skeleton;skills;soft tissue;stem cell therapy;stem cells;Structure;success;System;Technology;Testing;Therapeutic;tissue regeneration;Tissues;Training;Training Activity;Training Programs;transcriptome;transcriptomics;Transgenic Mice;Transplantation;Trauma;Universities;Up-Regulation;Washington;Western Blotting;Work;wound

PROJECT_TITLE: Mechanisms of Skeletal Morphogenesis During Digit Tip Regeneration

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Nutrition

PHR: Project Narrative The proposed research is relevant to public health since it focuses on dissecting the mechanisms underlying the regulation of a highly conserved signaling complex (TORC1) known to play an important role in cancer development, diabetes, obesity and depression. The work may also reveal differences between the pathways that control cell growth in lower eukaryotes and humans--opening the door to creating drugs that can selectively block the growth of fungal pathogens.

PI_NAMEs: CAPALDI, ANDREW PAUL (contact)

PROJECT_TERMS: Address;Amino Acids;Binding;Binding Proteins;Biochemical;biological adaptation to stress;cell growth;Cells;Cellular Metabolic Process;Complex;Data;Development;Diabetes Mellitus;Diphosphates;Disease;Dissection;Drug Design;Enzymes;Epilepsy;Eukaryota;Event;experimental study;Exposure to;fly;follow-up;G-Protein-Coupled Receptors;Genetic;Glucose;Grant;Growth;Guanosine Triphosphate Phosphohydrolases;hormonal signals;Hormones;Human;Hyperactivity;improved;innovation;inorganic phosphate;Inositol;Investigation;Knock-out;Lysosomes;Malignant Neoplasms;Maps;Membrane Proteins;Mental Depression;model organism;Monomeric GTP-Binding Proteins;Movement;Mus;Nitrogen;Nutrient;Obesity;pathogenic fungus;Pathway interactions;Pharmaceutical Preparations;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Play;Prions;protein function;Proteins;Proteomics;Public Health;Regulation;Repression;Research;Role;Saccharomyces cerevisiae;Saccharomycetales;Serine;Signal Pathway;Signal Transduction;Sirolimus;Starvation;Stress;Sulfur;System;Testing;Time;transmission process;Vacuole;Work;Yeasts

PROJECT_TITLE: Dissection of the TORC1 Signaling Network in Yeast

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative By a poorly understood process, a host enzyme adds extra methyl groups to the Guanosine-cap of HIV-1 RNA, altering its shape and function in a way that bolsters HIV-1 infectivity by 1000-fold with untoward effects on the host. Interdisciplinary experiments are proposed to define the details of the poorly understood process, and to explain the drastic increase in HIV infectivity on susceptible immune cells.

PI_NAMEs: BORIS-LAWRIE, KATHLEEN A. (contact);HENG, XIAO

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Achievement;Address;Anti-Retroviral Agents;Anti-viral Therapy;arm;Basic Science;Binding;biological adaptation to stress;Cells;Cellular Stress;Chronic;chronic infection;Clinical;Closure by clamp;Communication;Complex;Coupled;Cryoelectron Microscopy;Data;Detection;Development;Documentation;Drug resistance;druggable target;Environment;Enzymes;Epigenetic Process;Equilibrium;Evolution;exhaust;exhaustion;experience;experimental study;Foundations;FRAP1 gene;fundamental research;Future;Gene Expression;Generations;Goals;Guanosine;HIV;HIV-1;Homodimerization;Hypermethylation;Immune;immune activation;Immune signaling;Immunologics;Innate Immune Response;innovation;insight;Introns;Knowledge;Licensing;Link;Mediating;Messenger RNA;methyl group;Methylation;Modeling;Modification;Molecular;Molecular Immunology;molecular modeling;Molecular Probes;Molecular Virology;Myeloid Cells;National Institute of Allergy and Infectious Disease;novel;Nuclear;Outcome;pathogenic virus;Pathway interactions;Patients;Pharmaceutical Preparations;Plasma;Post-Transcriptional Regulation;Post-Transcriptional RNA Processing;Precipitation;Predisposition;prevent;Process;Production;Property;Proteins;Public Health;Publishing;recruit;Regulation;Reporting;Research;rev-Responsive Elements;Ribonucleoproteins;RNA;RNA Caps;RNA helicase A;Role;Scientist;sensor;Shapes;small molecule;structural biology;Structure;T-Lymphocyte;Therapeutic;tool;Transcript;translational study;Translations;Validation;Viral;Viral Genes;Viral Load result;Viral Proteins;Viral Regulatory Proteins;viral RNA;Virion;virology;virus host interaction;Virus Replication;vpr Gene Products;Work;Yin

PROJECT_TITLE: Epigenetic modification of HIV-1 Cap

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-X (03)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Emerging Infectious Diseases;Hematology;Infectious Diseases;Regenerative Medicine

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative In order to accurately determine the volume concentrations of different molecular components of the vascularized thrombosis organ-on-a-chip models developed in the parent grant, a new imaging technology will be built and tested thoroughly to properly identify and match experimental absorption curves to known values of the tissue components. Specifically, this project will develop the ‘photoacoustic fingerprinting’ method which will be used to identify different concentrations of varying molecules by their volume by comparing a variety of different photoacoustic intensity values at different wavelengths, and be examined and ‘matched’ to every model in the simulated library. This new technology will have the potential to identify proteins and larger molecules in the engineered tissues of the organ-on-a-chip system, like fat, proteins, fibrin, platelets, glucose and SARS-CoV-2, based on the absorption spectrum for further applications.

PI_NAMEs: YAO, JUNJIE ;ZHANG, Y. SHRIKE  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: 2019-nCoV;absorption;Blood Platelets;Blood Vessels;Fatty acid glycerol esters;Fibrin;Fingerprint;Glucose;Hemoglobin;Image;Imaging technology;Libraries;Measurement;Methods;Modeling;Molecular;new technology;organ on a chip;parent grant;photoacoustic imaging;Proteins;screening;System;Testing;Therapeutic;Thromboembolism;Thrombosis;Tissue Engineering;Tissues;Universities;Vascularization

PROJECT_TITLE: High-throughput Imaging-integrated Vascular Model for Understanding Thromboembolism and Therapeutics Screening


ADMINISTERING_IC: AA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Sleep Research;Substance Misuse

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE Studies provide compelling evidence to support the hypothesis that disruption of circadian homeostasis is a plausible susceptibility factor for host and organ-specific vulnerability to alcohol-induced pathologies. Phase I of this R24 Center provided support and services to nearly 60 investigators to enable the exploration of the role of circadian rhythms in alcohol-induced pathologies. Continuation of this R24 Center will engage and provide researchers with the skills, resources, and assistance to explore innovative hypotheses and bring new investigators into the field of alcohol research which is expected to lead to the identification of novel targets and interventions to prevent and treat alcohol-induced organ damage.

PI_NAMEs: KESHAVARZIAN, ALI  (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Administrative Supplement;Alcohol consumption;alcohol research;alcohol use disorder;Alcohols;Animals;Apical;Applications Grants;Awareness;Cell Line;Chronotherapy;circadian;Circadian Dysregulation;Circadian Rhythms;clinically significant;Collaborations;Communities;Consultations;cost;Data Analyses;DNA;Evaluation;Faculty;Funding;Homeostasis;Human;In Vitro;Individual;Inflammation;Infrastructure;innovation;Integration Host Factors;interest;International;Intervention;intestinal barrier;Intestines;Luciferases;Measurement;Mediating;meetings;Melatonin;Mentors;microbiota;Modeling;Molecular;Monitor;mouse model;mRNA Expression;Mus;National Institute on Alcohol Abuse and Alcoholism;novel;Organ;Organ failure;Organoids;Pathology;Persons;Phase;Predisposing Factor;Predisposition;prevent;programs;Proteins;Publications;R24;repository;Research;Research Personnel;research study;Resources;response;Rodent;Role;sample collection;Sampling;Services;single-cell RNA sequencing;skills;success;sugar;symposium;Testing;Therapeutic;Tissue Stains;Tissues;Training;Universities;urinary;virtual;Visit

PROJECT_TITLE: Center for Circadian Rhythms and Alcohol-Induced Tissue Damage

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


NIH_SPENDING_CATS: Duchenne/ Becker Muscular Dystrophy;Genetics;Human Genome;Muscular Dystrophy;Pediatric;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This K01 proposal aims to elucidate how caspase-mediated nuclear pore complex trimming enables myogenesis over short time scales but drives muscular dystrophies over longer time scales. The non-apoptotic functions of caspases and the direct role of the nuclear pore complex in muscle biology are examined. More broadly, this project will reveal new nuclear transport-dependent proteins and pathways that are involved in the formation and deterioration of skeletal muscles.

PI_NAMEs: CHO, UKRAE  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Apoptosis;Apoptotic;Binding;Binding Proteins;Biological;Biology;Caspase;Cell Death;Cell Fractionation;Cell Nucleus;Cells;ChIP-seq;Chronic;Chronic Disease;Cleavage Under Targets and Release Using Nuclease;cofactor;Complex;coping;Cytoplasm;Data;Deacetylase;derepression;Deterioration;Disease Progression;Dissociation;Distal;Duchenne muscular dystrophy;endoplasm;endoplasmic reticulum stress;Equation;fascinate;Focal Adhesions;Foundations;gene repression;Genes;Genetic Transcription;Genome;genome-wide;Goals;Health;Homeostasis;Impairment;Individual;invention;Life;Life Cycle Stages;Limb structure;Limb-Girdle Muscular Dystrophies;Mass Spectrum Analysis;Mediating;Membrane;Mentored Research Scientist Development Award;mouse model;mRNA Export;Muscle;Muscle Cells;Muscle Development;Muscle Fibers;muscle stress;Muscular Atrophy;Muscular Dystrophies;Myoblasts;myogenesis;Myopathy;novel strategies;novel therapeutic intervention;Nuclear;Nuclear Export;Nuclear Pore Complex;nucleocytoplasmic transport;Nucleosomes;Outcome;Pathologic;Pathway interactions;Patients;paxillin;Peptide Hydrolases;Phenotype;pleiotropism;prevent;Process;promoter;Protein Biosynthesis;Proteins;Proteome;PTK2 gene;Regulation;Regulation of Proteolysis;Research;Risk;Role;Sarcoplasmic Reticulum;Signal Transduction;Site;Skeletal Muscle;Stress;stressor;Structure;System;Time;transcription factor;transcriptome sequencing;Tubulin;ZYX gene

PROJECT_TITLE: Caspase-mediated nuclear pore complex trimming in myogenesis and muscular dystrophies

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pain Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Sex, Hormones and Identity affect Nociceptive Expression Observed in Non-binary adults (SHINE ON) Project Narrative This project addresses health equity through investigation of pain sensitivity and immune cell function via inclusion of a traditionally understudied at-risk gender minority group – non-binary adults. The proposed project builds on the ongoing SHINE project (1R01-NR019417-01) in response to the Notice of Special Interest (NOSI: NOT-OD-22-032) and is directly in line with the 2022-2026 NINR Strategic Plan framework and priorities. This work will significantly add to our body of knowledge and the ways in which sex assigned at birth, gender identity and hormones affect pain and immune function in adults, with a special emphasis on sexual and gender minority groups.

PI_NAMEs: GOODIN, BUREL R.;SORGE, ROBERT  (contact)

PROGRAM_OFFICER_NAME: WOLFF, JOSHUA R

PROJECT_TERMS: Address;Adult;Affect;Age;aged;assigned female at birth;assigned male at birth;Attention;Birth;Categories;Cell Physiology;Cells;chronic pain;cis-female;cis-male;cisgender;Cities;Clinical;Clinical Research;Communities;community organizations;Coupled;Development;Discrimination;Disparity;Equity;Face;falls;Female;Fostering;Gender;gender fluid;Gender Identity;gender minority group;gender minority stress;gender nonconforming;genderqueer;Goals;Health;health equity;Hormone replacement therapy;Hormones;Immune;immune function;Immune system;Individual;Inequity;interest;Investigation;Knowledge;lens;Lesbian Gay Bisexual Transgender Queer;Literature;Magic;Maintenance;male;marginalization;Measures;member;men;Mental Depression;Mental Health;Minority Groups;National Institute of Nursing Research;Nociception;nonbinary;Nursing Research;Outcome;Pain;Pain Measurement;pain perception;pain sensation;pain sensitivity;parent project;Parents;Play;Population;Predisposition;Psychosocial Factor;Quality of life;racial diversity;recruit;Reporting;Research;Research Priority;research study;resilience;response;Risk;Role;Sampling;sex;sex assigned;Sex Differences;sexual minority group;social factors;social health determinants;social stigma;Strategic Planning;Stress;Testing;theories;transgender;transgender men;transgender women;Woman;Work

PROJECT_TITLE: Sex, Hormones and Identity affect Nociceptive Expression (SHINE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(53)-R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Orphan Drug;Racial and Ethnic Minority Health Research;Rare Diseases;Women's Health Research

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE Native Hawaiian and Pacific Islander (NHPI) women with inflammatory breast cancer have the highest breast cancer incidence and mortality rates compared to the other racial/ethnic populations of Hawaii. This project will determine the molecular and immunological differences in IBC tumors from NHPI and non-NHPI (Asian American and White) patients that are associated with NHPI's disparate risk and outcome. Results of our study will provide insights to identify therapeutic targets for IBC patients from specific racial or ethnic backgrounds.

PI_NAMEs: UENO, NAOTO T. (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Address;Administrative Supplement;aggressive breast cancer;Asian Americans;Award;Biological;Breast Cancer Patient;cancer health disparity;cancer subtypes;CCL2 gene;CCL20 gene;cell type;Cells;Characteristics;chemokine;cohort;CXCL5 gene;Data;Data Set;Death Rate;Development;differential expression;Disease Outcome;Disparate;Disparity;Epidermal Growth Factor Receptor;ethnic difference;ethnic disparity;Ethnic Origin;Ethnic Population;experience;Funding;Gene Expression Profile;Genetic;Hawaii;Hospitals;IL8 gene;Immune;Immunofluorescence Immunologic;Immunologics;improved;Incidence;inflammatory breast cancer;insight;Institution;Investigation;Japanese;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Molecular;Molecular Analysis;Molecular Profiling;Molecular Target;mortality;Native Hawaiian or Other Pacific Islander;new therapeutic target;Outcome;parent grant;Parents;Pathway interactions;Patients;Population;Prognosis;Race;racial difference;racial disparity;Research;Residual state;response;Risk;Sampling;Spatial Distribution;Stains;Survival Rate;Testing;Therapeutic;therapeutic target;Tissue Banks;Tissues;transcription factor;transcriptome sequencing;transcriptomics;treatment strategy;trend;tumor;Tumor Biology;tumor microenvironment;tumor registry;Tumor Tissue;tumor-immune system interactions;understudied cancer;Universities;Woman

PROJECT_TITLE: Development of a novel therapy targeting the tumor microenvironment in inflammatory breast cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: The objective of this proposal is to evaluate the mechanisms by which Jak2 signaling drives persistent androgen receptor (AR) expression in castrate-resistant prostate cancer (CRPC), and establish whether pharmacological Jak2 inhibition by the new-generation Jak2 inhibitors, Pacritinib and Fedratinib, can overcome AR expression in CRPC and block CRPC growth when resistant to AR-targeted therapy. The proposed project is important because of translational significance and potential for high impact on disease.

PI_NAMEs: DEHM, SCOTT M.;NEVALAINEN, MARJA T (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: 3-Dimensional;abiraterone;Acceleration;Acetates;advanced prostate cancer;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgen Suppression;Androgens;antagonist;AR gene;Automobile Driving;cancer genome;Cancer Patient;Castration;Cell Nucleus;Cell Survival;Cells;Cessation of life;chromatin immunoprecipitation;chromosome conformation capture;Clinical;clinical development;Clinical Research;Combined Modality Therapy;companion diagnostics;Data;Development;Dimerization;Disease;Disease Progression;Distant;efficacious treatment;efficacy evaluation;enzalutamide;Failure;FDA approved;field study;Gene Expression;Generations;Genes;Genetic Transcription;Genome engineering;Growth;Growth and Development function;In Vitro;in vivo;in vivo Model;inhibitor;Investigation;Length;Ligand Binding Domain;Malignant neoplasm of prostate;Medical;Messenger RNA;Modeling;Molecular Target;mRNA Expression;Mus;Myelofibrosis;next generation;next generation sequencing;novel;novel therapeutic intervention;Nuclear Translocation;Pathway interactions;Patients;pharmacologic;Phase;phase II trial;phase III trial;Phenotype;Phosphorylation;preclinical efficacy;preclinical study;predicting response;prevent;prostate cancer cell;prostate cancer cell line;prostate cancer metastasis;prostate cancer model;prostate cancer progression;protein expression;Protein Tyrosine Kinase;Proteins;receptor expression;Receptor Inhibition;Regulation;Residual state;Resistance;RNA Splicing;Serum;Signal Induction;Signal Pathway;Signal Transduction;single-cell RNA sequencing;standard of care;targeted treatment;Therapeutic;therapeutic evaluation;therapy development;Toxic effect;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Translating;tumor;tumor growth;tumor xenograft;Variant;virtual;Work;Xenograft procedure

PROJECT_TITLE: Pharmacological Jak2 inhibition to overcome androgen receptor aberrations in prostate cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE Thyroid cancer is diagnosed less frequently but is more deadly for individuals who self-identify as African American/ Black or Latino/Hispanic in comparison to individuals who self-identify as non-Hispanic Whites. In this study, we aim to determine whether race-specific differences in gene activity and DNA methylation for African American/Black and Latino/Hispanic in comparison to non-Hispanic Whites are involved in thyroid cancer disparities.

PI_NAMEs: HAHN, MARIA  (contact);YIM, JOHN H

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Aberrant DNA Methylation;Address;African American;African American population;American;Automobile Driving;Benign;Biological;Biological Markers;Biology;Biopsy;bisulfite sequencing;Black race;Breast;Cancer Diagnostics;cancer health disparity;Cancer Patient;caucasian American;cohort;Compassion;Cytopathology;Data;Diagnosis;Diagnostic;Disparity;Distant Metastasis;DNA;DNA Methylation;Early Diagnosis;Epigenetic Process;epigenomics;Ethnic Origin;European;Funding;Gene Expression;Genes;Genetic;Genetic Transcription;genome-wide;Goals;Head and Neck Cancer;health care quality;health equity promotion;Health Services Accessibility;Hispanic;improved;Individual;insight;Institution;Insurance;Latino;Link;Malignant - descriptor;Malignant neoplasm of thyroid;Malignant Neoplasms;Metastatic Neoplasm to Lymph Nodes;Methylation;molecular diagnostics;Morbidity - disease rate;mortality;Mutation;Nodule;Not Hispanic or Latino;Oncogenes;Papillary thyroid carcinoma;Patients;Play;Population;Predisposition;Race;racial minority;Renal Carcinoma;Research;Role;Skin Cancer;Testing;Thyroid Gland;Thyroid Nodule;Time;Tumor Suppressor Proteins;United States;Validation;Variant

PROJECT_TITLE: Validation of Epigenomic Biomarkers for Thyroid Cancer Diagnostics


ORG_CITY: KANSAS CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE KIPM’s BME Core created a cadre of plastics microfluidic tools to efficiently isolate liquid biopsy markers, including novel markers – nanoparticles and extracellular vesicles (EVs) to support projects initiated by local and national investigators and the new Research Project Leaders (RPLs) in KIPM. The requested ARCTM Fluorescence Microfluidic Resistive Pulse Sensing (F-MRPS) instrument will be highly beneficial for our users in evaluation of nanoparticles and EVs concentration, size, presence of lipid bilayer imbedded antigens, and internal cargo. More effective metrology provided by ARCTM F-MRPS will enable strong science through better-controlled experiments and understanding of characteristics and biogenesis of EVs.

PI_NAMEs: GODWIN, ANDREW K. (contact);SOPER, STEVEN ALLAN;YU, ALAN S

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Antigens;Bacteria;Biogenesis;Biological;Biological Assay;Biological Markers;Biomedical Engineering;Blood;Cells;Centers of Research Excellence;Characteristics;Clinical;Data;Devices;Disease;Engineering;Evaluation;experimental study;extracellular vesicles;Fluorescence;Funding;Goals;Human Resources;Infrastructure;innovation;instrument;instrumentation;Kansas;Lipid Bilayers;lipid nanoparticle;Lipids;Liposomes;liquid biopsy;Liquid substance;Measurement;member;Membrane Proteins;metrology;Microfluidics;Molecular;nanofluidic;nanoparticle;nanopolymer;novel;novel marker;Optics;Output;particle;Peer Review;Physiologic pulse;Pilot Projects;Plasma;Plastics;Play;precision medicine;Process;Property;Research Personnel;Research Project Grants;Role;Saliva;Sampling;Science;Secure;small molecule;Technology;tool;Training;Translational Research;Urine;Virus;Work

PROJECT_TITLE: The Kansas Institute for Precision Medicine - F-MRPS


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Pancreatic Ductal Adenocarcinoma (PDAC), a common type of pancreatic cancer, is the fourth leading cause of cancer-related deaths in both men and women in the United States. The goal of the proposed project is to develop an artificial intelligence algorithm based on computed- tomography scans to identify individuals at high risk for PDAC in African Americans, which may allow early detection of PDAC and increase survival rate.

PI_NAMEs: LI, DEBIAO  (contact);PANDOL, STEPHEN J.;YAZICI, CEMAL

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: abdominal CT;Administrative Supplement;African American;African American population;Age;Artificial Intelligence;artificial intelligence algorithm;Biological;Biopsy;Cancer Etiology;Categories;Cessation of life;Chicago;Clinical;clinically significant;Collaborations;Data;Death Rate;Diagnosis;Diagnostic;Diagnostic Imaging;Disease;Early Diagnosis;Early treatment;Enrollment;Ethnic Origin;experience;follow-up;Future;Gender;General Population;Goals;health inequalities;Heterogeneity;high risk;Hispanic Populations;Illinois;Image;imaging study;improved;Incidence;Individual;Low Prevalence;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical center;men;Modeling;Morphology;mortality;Not Hispanic or Latino;Operative Surgical Procedures;Pancreas;pancreas imaging;Pancreatic Diseases;Pancreatic Ductal Adenocarcinoma;parent project;patient population;Patients;Pilot Projects;Population;predictive modeling;premalignant;Race;racial disparity;radiologist;radiomics;Research;Resectable;Risk;Sample Size;Scanning;Survival Rate;Time;tumor;United States;Universities;Woman;X-Ray Computed Tomography

PROJECT_TITLE: Predicting Pancreatic Ductal Adenocarcinoma PDAC Through Artificial Intelligence Analysis of Pre Diagnostic CT Images in African Americans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(03)-M]


ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: NARRATIVE Adenomas are early lesions of colorectal cancer, but only a subset of adenomas progress and become cancer. In light of the well characterized clinical natural history of adenomas, we plan to study them as early lesions and to determine the mechanisms involved in the formation and progression of early precancerous lesions. We hypothesize that adenoma progression requires a suite of hallmark behaviors and that these behaviors are induced by adenoma autonomous factors (e.g. cancer driver gene mutations) and adenoma nonautonomous factors from the “primed colon” or adenoma microenvironment. Our proposed studies will integrate basic and translational cancer research projects to iteratively examine the direct causal relationships and interactions of adenomas, the colon “primed” microenvironment, and host-systemic factors as “co-organizers” of adenoma initiation and/or progression.

PI_NAMEs: DEY, NEELENDU ;GRADY, WILLIAM MALLORY (contact)

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Aberrant DNA Methylation;adenoma;Affect;Architecture;Atlases;Basic Cancer Research;Behavior;Biological Markers;Biology;Cancer Etiology;cancer genetics;Cancer Research Project;cancer type;Cells;Cessation of life;Clinic;Clinical;clinical application;cohort;Collaborations;Colon;colon cancer patients;Colonic Adenoma;Colorectal Adenoma;Colorectal Cancer;colorectal cancer prevention;colorectal cancer progression;Data Set;deep sequencing;DNA Sequence Alteration;dysbiosis;Epigenetic Process;Epithelial Cells;experience;Fibroblasts;Gene Mutation;Goals;gut microbiome;Human;human disease;Immune;Individual;Indolent;innovation;Lesion;Light;Malignant Neoplasms;methylation pattern;methylome;microbiome;Mission;Molecular;mouse model;Multiomic Data;mutant;Mutation;Natural History;novel;Pathogenesis;Patients;Persons;Positioning Attribute;premalignant;Recording of previous events;Research Personnel;risk prediction;Science;senescence;Sessile Lesion;Technology;Testing;Tissues;translational cancer research;Translational Research;Translations;Tumor Promotion

PROJECT_TITLE: Understanding adenoma progression: Interplay among tissue microenvironment, clonal architecture, and gut microbiome


ADMINISTERING_IC: HG

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Public Health Relevancy Statement Gene expression is tightly controlled in time and space and is governed by protein-nucleic acid (DNA and RNA) interactions. There are hundreds of DNA- and RNA-binding proteins that regulate gene expression and many are mutated in disease, but we lack facile approaches to map these proteins to their DNA/RNA targets. Here we propose to develop an innovative set of tools that will give every molecular biology lab the possibility to obtain comprehensive cell-type specific protein DNA/RNA interaction maps, a necessity to understand gene expression regulation and therefore disease development.

PI_NAMEs: GUTTMAN, MITCHELL ;JOVANOVIC, MARKO  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Address;Amyotrophic Lateral Sclerosis;Antibodies;Bar Codes;Benchmarking;Binding;Binding Proteins;Binding Sites;Biological;Biological Assay;Cell Line;cell type;Cells;Chromatin;chromatin immunoprecipitation;chromatin modification;combinatorial;Communities;Complex;Consumption;cost;crosslink;Data;Data Set;Development;Disease;disease model;DNA;DNA Binding;DNA mapping;DNA-Binding Proteins;DNA-Protein Interaction;empowerment;Ensure;epigenomics;experimental study;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Transcription;genome-wide;genomic data;Genomic DNA;genomic RNA;Genomics;Goals;High-Throughput Nucleotide Sequencing;histone modification;human disease;Immunoprecipitation;Individual;innovation;innovative technologies;insight;interest;International;Link;Maps;Measurement;Messenger RNA;Methods;Molecular Biology;mRNA Transcript Degradation;Mutate;Mutation;Neurodegenerative Disorders;Neurons;novel;nucleic acid mapping;Nucleic Acids;Patients;Population;Post-Translational Protein Processing;posttranscriptional;Process;protein expression;Proteins;Protocols documentation;Public Health;recruit;Research;Research Personnel;RNA;RNA Binding;RNA Sequences;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;Sampling;Sensitivity and Specificity;Specificity;Technology;Time;tool;transcription factor;Transcriptional Regulation;transcriptome;Translations

PROJECT_TITLE: Extensive multiplexing of protein nucleic-acid interactions to comprehensively study gene expression regulation from chromatin to mRNA degradation

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

PHR: The Veterans Health Administration is facing increasing numbers of older Veterans suffering from multiple chronic conditions, who are frequently hospitalized for ambulatory care sensitive conditions (ACSC) at high cost. While many efforts to redesign outpatient care for this vulnerable group have failed to reduce health care utilization, VA Home-Based Primary Care has recently been demonstrated to reduce rates of hospitalization for ACSCs by 27%. The aims of this proposal are 1) Characterize patterns of enrollment and care delivery within HBPC, and determine clinical and systems correlates of preventable hospitalizations, 2) Assess HBPC provider perceptions of appropriate patient selection and care delivery patterns, core functions of HBPC, and barriers and facilitators to HBPC performance, and 3) Develop and test a pilot intervention to promote best practices in HBPC.

PI_NAMEs: EDWARDS, SAMUEL T (contact)

PROJECT_TERMS: Academic Detailing;acceptability and feasibility;Address;Ambulatory Care;Area;care coordination;care delivery;career;Caring;chronic care model;Chronic Disease;Clinical;clinical predictors;cohort;Complex;cost;Data;Data Analyses;Data Collection;density;design;Development;Effectiveness;Elements;Enrollment;Evaluation;experience;Feedback;Focus Groups;formative assessment;Goals;Health Care Costs;health care service utilization;Health Services;Health Services Administration;Health Services Research;high risk;Home;Hospitalization;hospitalization rates;Hospitals;implementation facilitators;implementation intervention;implementation science;improved;insight;Intervention;intervention refinement;Interview;Intuition;Investigation;Knowledge;Learning;Length;Literature;longitudinal analysis;Medical;Medication Management;Mentors;Mentorship;Methods;Modeling;multi-component intervention;Multicenter Trials;multiple chronic conditions;Nature;Outcome;Palliative Care;Patient Care;Patient Selection;patient subsets;Patients;Pattern;Perception;Performance;Phase;Physicians;prevent;Primary Care;primary care patient;primary care provider;primary care services;primary care team;Process;programs;Provider;Quality of Care;Regression Analysis;Research;Research Methodology;Research Personnel;secondary analysis;Selection Criteria;service delivery;Services;Site;skills;social;social health determinants;Structure;Subgroup;success;support tools;System;team-based care;Telephone Interviews;Testing;therapy development;Training;Training Programs;Variant;Veterans;Veterans Health Administration;Vulnerable Populations;Work

PROJECT_TITLE: Optimizing Outcomes in Home-Based Primary Care

STUDY_SECTION_NAME: HSR&D Career Development Award [CDA0]


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: This application describes the research conducted since 2011, highlighting the applicant’s current focus and its relevance to Veterans’ healthcare. The applicant’s research has focused on examining and improving the quality and safety of care in VA, important areas of study given increasing pressures for the VA to compare its performance with that of the private sector. Recent changes in VA national priorities (“providing greater choice” and “improving timeliness in access”) have also influenced the applicant’s research. Her studies now include Veterans who receive care in the community (CC) purchased by the VA as well as those who receive care in VA facilities. Through collaboration with the Office of Community Care, this work will provide VHA with important information on areas for safety improvement in CC; it will evaluate the timeliness of the CC provided; and examine the quality of care that Veterans receive in CC.

PI_NAMEs: ROSEN, AMY K (contact)

PROJECT_TERMS: Acute;Adopted;Area;Award;Awareness;Boston;career;Caring;Collaborations;Communities;Community Healthcare;cost;dashboard;Dedications;Educational process of instructing;Evaluation Research;Evaluation Studies;Faculty;Funding;Goals;Grant;Group Meetings;Health;health care service organization;Health Services;Health Services Research;Healthcare;Healthcare Systems;Homogeneously Staining Region;hospital performance;hospital readmission;Hospitals;Impact evaluation;implementation research;implementation science;Improve Access;improved;Individual;innovation;International;Leadership;Location;Manuscripts;Measurement;Measures;Medical;Mentors;Methods;military veteran;Modification;Monitor;next generation;Operative Surgical Procedures;Outcome;patient oriented;patient safety;Patients;Performance;Policies;Policy Maker;pressure;Private Sector;Productivity;programs;Quality of Care;Recommendation;Research;Research Activity;Research Personnel;research study;Risk Adjustment;Safety;Scientist;Services;skills;Statistical Methods;Students;Time;tool;Training;Training Activity;Translational Research;United States Agency for Healthcare Research and Quality;Universities;Veterans;Work;Writing

PROJECT_TITLE: HSR&D Senior Research Career Scientist Award

STUDY_SECTION_NAME: HSR-7 Capacity Building[HSR7]


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: The objective of this project is to test the efficacy of an individual treatment for post-traumatic stress disorder (PTSD) stemming from moral injury called Impact of Killing (IOK), compared to a present-centered therapy (PCT) control condition, and to determine the rehabilitative utility of IOK for Veterans with PTSD. Our first aim is to test whether IOK can help improve psychosocial functioning for Veterans, as well as PTSD symptoms. Our second aim is to determine whether IOK gains made by Veterans in treatment are durable, as measured by a six-month follow-up assessment. Veterans who kill in war are at increased risk for functional difficulties, PTSD, alcohol abuse, and suicide. Even after current PTSD psychotherapies, most Veterans continue to meet diagnostic criteria for PTSD, highlighting the need for expanding treatments for PTSD and functioning. IOK is a treatment that can be provided following existing PTSD treatments, filling a critical gap for Veterans with moral injury who continue to suffer from mental health symptoms and functional difficulties.

PI_NAMEs: MAGUEN, SHIRA  (contact)

PROJECT_TERMS: active control;Address;Aftercare;Alcohol abuse;Anger;Area;Attention;Behavior;Belief;care systems;Caring;Cessation of life;Clinical assessments;Clinical Treatment;Cognition;Cognitive;combat;combat veteran;Communities;Complex;Conflict (Psychology);Control Groups;cost;design;Development;Diagnosis;diagnostic criteria;Education;efficacy testing;efficacy trial;Evaluation;evidence base;expectation;experience;Exposure to;Family;Feeling;follow up assessment;follow-up;functional gain;Functional impairment;functional improvement;Funding;Generations;Goals;Grant;Guilt;Healthcare Systems;Impairment;improved;Individual;Intervention;Learning;Measures;Mediator;Mental Health;Modeling;Moral injury;Morals;novel;Outcome;Participant;Patients;Performance;Physiology;pilot trial;Post-Traumatic Stress Disorders;prevent;primary outcome;psychiatric symptom;psychological distress;psychological trauma;psychosocial;Psychotherapy;Quality of life;Randomized;Randomized, Controlled Trials;Rehabilitation therapy;response;Risk;Sample Size;San Francisco;secondary outcome;self-compassion;Self-Injurious Behavior;Severities;Shame;Signs and Symptoms;Site;skills;Social isolation;Spirituality;stem;suicidal;Suicide;suicide rate;symptomatic improvement;Symptoms;Target Populations;Testing;Thinking;Time;Trauma;treatment group;Veterans;Veterans Health Administration;Visit;Waiting Lists;War;Work

PROJECT_TITLE: A Novel Posttraumatic Stress Disorder Treatment for Veterans with Moral Injury

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE More than 330,000 (9%) of the 3.6 million infants born each year in the U.S. are admitted to a neonatal intensive care unit. Clinical research has greatly increased survival of the sickest infants, but many survivors have significant morbidity that persists into childhood and beyond. Innovative multicenter studies with large and diverse participation, like those conducted by the NICHD Neonatal Research Network, are needed to improve the long-term health of the next generation; the University of Texas Health Science Center at Houston has been an exemplary center in such research.

PI_NAMEs: RYSAVY, MATTHEW ALBERT (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Admission activity;Asian;Award;Bayesian Analysis;Bayesian Method;Beds;Biometry;Birth;Black race;career;Caring;Childhood;Clinical;clinical center;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Cohort Studies;Collaborations;Conduct Clinical Trials;Databases;Dedications;design;Development;Dose;early-career faculty;economic evaluation;Enrollment;Environment;Evidence Based Medicine;experience;extreme prematurity;Faculty;Feasibility Studies;follow-up;Future;Grant;Health;health economics;Health Sciences;Healthcare;high risk infant;Hispanic;Hour;Human Resources;Impairment;improved;Infant;Infrastructure;innovation;Institution;Intervention;intrapartum;Leadership;Lipids;Low Birth Weight Infant;Maternal-fetal medicine;Maternal-Fetal Medicine Units Network;Medical;medical schools;member;Mentors;Methodology;Methods;Mission;Morbidity - disease rate;mortality;Multicenter Neonatal Research Network;Multicenter Studies;multidisciplinary;National Institute of Child Health and Human Development;natural hypothermia;Necrotizing Enterocolitis;Neonatal;Neonatal Intensive Care Units;neonatal surgery;neonate;Neonatology;Neurodevelopmental Impairment;Newborn Infant;next generation;Not Hispanic or Latino;Obstetric Fetal Pharmacology;Operative Surgical Procedures;Outcome;participant enrollment;Perinatal;perinatal medicine;Phototherapy;Population;Population Heterogeneity;Pregnancy;Premature Birth;Premature Infant;Probability;Productivity;programs;Protocols documentation;Psychologist;Publishing;Race;randomized, clinical trials;Recording of previous events;Reference Standards;Reproducibility;Research;Research Design;Research Ethics;Research Infrastructure;Research Personnel;Role;Running;Science;secondary outcome;Site;skills;Statistical Models;statistics;stillbirth;Surgeon;Survivors;Talents;Texas;Time;tool;United States National Institutes of Health;Universities;Vitamin D supplementation;web site

PROJECT_TITLE: NICHD Neonatal Research Network (NRN): Clinical Centers (UG1 Clinical Trial Optional


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

ORG_CITY: LOWELL

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

PHR: There is currently an oversupply of graduates with doctoral degrees relative to the number of academic faculty positions available, including those in the aging research area. Therefore, there is currently a real, demonstrated need for educational programs that are focused on innovation and committed to teaching a broad set of industry based skills for those working on doctoral degrees. The UMass Lowell Innovative Fellows Training (LIFT) Program is designed to fill that programmatic need.

PI_NAMEs: BUCHHOLZ, BRYAN O (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Alzheimer's disease diagnostic;Area;Businesses;career;career development;clinical development;cohort;college;Communication;Dedications;design;Development Plans;Diagnostic;diagnostic development;Doctor's Degree;drug development;Ecosystem;Education;education research;Educational process of instructing;Engineering;Entrepreneurship;Faculty;Health Sciences;Healthcare;Industry;industry partner;innovation;Intellectual Property;Investments;Licensing;matriculation;Measurable;Mentorship;Occupations;Positioning Attribute;pre-clinical;preclinical development;programs;recruit;Research;Research Personnel;Resources;Running;Schools;skill acquisition;skills;Source;Therapeutic;therapeutic development;Time;Training;Training Programs;Underrepresented Minority

PROJECT_TITLE: UMass Lowell Innovative Fellows Training (UMass LIFT)


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Asthma;Burden of Illness;Cardiovascular;Chronic Obstructive Pulmonary Disease;Clinical Research;Contraception/Reproduction;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Lung;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Physical Activity;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE Increasing evidence suggests that early life and reproductive events, as well as exposures during pregnancy, may have long-term impacts cardiovascular and lung health of women and their children but most cohorts are not well equipped to support research addressing these questions. We propose to strengthen the shared infrastructure necessary to support research aimed at identifying intergenerational, reproductive and early life risk factors for CVD (CHD, stroke) and obstructive lung disease (COPD and asthma) in three cohorts – the Nurses’ Health Study II (NHS-II), the Growing Up Today Study (GUTS) and the Nurses’ Health Study 3 (NHS3) – by focusing in four areas: 1) the maximization of existing resources, 2) the collection of biological specimens and in-person measurements of blood pressure and anthropometric data, 3) the expansion of web-based mobile technology and “Big Data” capabilities for the cohorts, and 4) strengthening our capability for data sharing. The ability to combine biomarker data, state-of-the-art mobile high-resolution measures, and traditional epidemiologic risk factor data, collected across generations and throughout the life-course in three related cohorts will enable us and others to conduct powerful etiologic and translational research.

PI_NAMEs: CHAVARRO, JORGE EDUARDO (contact);MANSON, JOANN ELISABETH

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;Adult Children;Affect;African American population;Age;Air Pollution;analytical tool;Anthropometry;Area;Asthma;attributable mortality;Behavioral;Big Data;biobank;Biological;Biological Markers;Biological Specimen Banks;Blood Pressure;built environment;cardiorespiratory fitness;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cellular Phone;Cessation of life;Characteristics;Child;Chronic Obstructive Pulmonary Disease;Clinical;cohort;Collection;Communities;Coronary heart disease;Data;Data Collection;data infrastructure;data repository;data resource;data sharing;Databases;Diet;digital phenotyping;Dimensions;Disease;disorder risk;DNA;Dyslipidemias;Educational Materials;Electronic cigarette;Environmental Exposure;Epidemiology;epidemiology study;Erythrocytes;ethnic minority;Etiology;Event;excessive weight gain;Exposure to;follow-up;Food;Food Access;frontier;Future;Generations;Genes;Geographic Distribution;Geographic Information Systems;Geography;Gestational Diabetes;Goals;Green space;Health;Health Care Costs;Heart Diseases;Hispanic Americans;Hypertension;Individual;Infrastructure;Infrastructure Activities;innovation;interest;intergenerational;Life;Life Cycle Stages;lifestyle factors;Link;Long term disability;Lung Diseases;lung health;Maintenance;Marijuana;Measurement;Measures;Medical History;Medical Records;men;Minority;mobile computing;Morbidity - disease rate;mortality;Mothers;novel;Nurses' Health Study;Obesity;Obstructive Lung Diseases;offspring;Online Systems;Participant;Periodicals;Persons;Physical activity;Plasma;Pregnancy;Pregnancy Complications;pregnancy disorder;Premature Birth;Process;Protocols documentation;Questionnaires;racial minority;Recording of previous events;Recreation;Reporting;reproductive;Research;Research Support;Resolution;Resources;Risk;Risk Factors;RNA;Rural Population;Sleep;Socioeconomic Status;spatiotemporal;Specimen;stool sample;Stroke;Technology;Temperature;Total Lung Capacity;Translational Research;United States;Update;Urine;Visualization software;Woman;Women's Health;Women's mortality

PROJECT_TITLE: Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic research


NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE The Analysis, Visualization, and Informatics Lab-space (AnVIL) is a cloud-based computing platform that brings together genomics resources and broad access to genomics datasets to enhance collaboration across research teams. The AnVIL Clinical Environment for Innovation and Translation (ACE-IT) team will amplify the existing AnVIL platform by first engaging with diverse partners to characterize barriers to clinical genomics research on cloud environments integrating tools that enable clinical genomics research methods. The team will then work with existing AnVIL teams and partners to integrate diverse datasets and implement clinical genomics tools to support the rapidly evolving field of clinical and translational genomics research.

PI_NAMEs: CARROLL, ROBERT J (contact);LEBO, MATTHEW S

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Adopted;Adoption;All of Us Research Program;American Heart Association;Biomedical Research;Breast Cancer Risk Factor;Cancer Control;cancer prevention;Capital;Clinical;Clinical Data;Clinical Research;cloud based;Cloud Computing;Collaborations;Collection;Communities;Complex;computational platform;computing resources;Cost Control;Data;data integration;data resource;Data Science;Data Set;data space;design;Development;Diagnosis;Disease;disease diagnosis;diverse data;Ecosystem;Electronic Medical Records and Genomics Network;Environment;Equity;evidence base;Family;Foundations;Funding;General Hospitals;Genome;genome resource;genome sciences;genomic data;genomic tools;Genomics;Growth;hazard;Health;health care settings;Health Disparities Research;Health Resources;Healthcare;Hospitals;improved;indexing;Individual;Informatics;informatics tool;Infrastructure;Ingestion;innovation;Investments;Knowledge;Libraries;Massachusetts;meetings;member;Methods;Mission;National Human Genome Research Institute;new technology;novel;Outcome;Patient Care;Persons;Pharmacogenomics;phenotypic data;polygenic risk score;Population;Population Heterogeneity;Process;Rare Diseases;Recording of previous events;Research;Research Methodology;Research Personnel;Resources;Risk;Risk Assessment;Risk Factors;Security;Services;social health determinants;Stream;support tools;System;Technology;Time;tool;Training Support;translational approach;translational genomics;Translational Research;Translations;United States National Institutes of Health;Visualization;Woman;Work;working group

PROJECT_TITLE: AnVIL Clinical Environment for Innovation and Translation (ACE-IT): Supplement for Clinical Data Integration meeting


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Data Science;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative This proposal is relevant to public health because it works to unlock the complex intersection of addiction and big data for a more diverse workforce. Creating curated and scalable training for a broad audience of trainees can enhance our ability to solve problems in addiction science. This research aligns with NIH NIDA's goal to provide the highest quality research training to a diverse workforce.

PI_NAMEs: ADAMS, MEREDITH C. B.;BROOKS, AMBER KELLER (contact);HURLEY, ROBERT WILLSON;NELSON, ARIANA

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: Acceleration;addiction;advanced analytics;algorithm training;algorithmic bias;Algorithms;analytical method;Area;Artificial Intelligence;Awareness;barrier to care;Big Data;Bioethical Issues;Biological Models;Career Choice;chronic pain;Clinical;Clinical Trials;cohort;Collaborations;college;Communities;Complex;Critical Thinking;Data;Data Analyses;Data Analytics;Data Collection;Data Commons;data infrastructure;data modeling;Data Science;data science resource;Data Scientist;Data Set;Databases;Development;Discrimination;diverse data;Diverse Workforce;doctoral student;Education;Educational Intervention;electronic health data;Emerging Technologies;Enrollment;Ethics;Evaluation;evidence base;experience;FAIR principles;Fostering;Foundations;Future;Goals;health disparity;health equity;health inequalities;Historically Black Colleges and Universities;Individual;Infrastructure;Institution;Instruction;interest;Knowledge;Leadership;Link;literacy;meetings;Mental Health;Methodology;Methods;Mining;Mission;Modality;National Institute of Drug Abuse;Natural Language Processing;next generation;novel;opioid use disorder;Outcome;Participant;Pathway interactions;Postdoctoral Fellow;practical application;pre-doctoral;Problem Solving;program dissemination;Program Evaluation;programs;Public Health;PubMed;recruit;Reporter;Reporting;Research;Research Design;Research Personnel;Research Support;Research Training;Resources;risk mitigation;Science;Scientist;secondary analysis;skills;social stigma;Software Tools;Structure;Students;tool;Training;Training Programs;training project;Training Support;undergraduate student;United States National Institutes of Health;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Developing A Diverse Workforce: Advancing Data Science for Addiction Research and Professional Training (ADAPT)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SXC-N (A1)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Hematology;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Before the SARS-CoV-2 pandemic, Mtb had surpassed HIV/AIDS becoming the leading cause of human deaths by an infectious agent and resulted in 1.3 million deaths in 2019. The WHO estimates that globally 3.3% of new cases and 18% of previously treated cases had multidrug resistant TB(MDR-TB) in 2019, with an imminent need to develop new chemotherapeutic strategies to prevent TB disease progression. The aim of this proposal is to identify the different mechanisms which allow Mtb to utilize heme iron in the

PI_NAMEs: MITRA, AVISHEK  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Cessation of life;COVID-19 pandemic;Disease Progression;Ferritin;Heme;Heme Iron;Hemoglobin;HIV/AIDS;Human;Immunity;Infectious Agent;Iron;Lactoferrin;lung pathogen;Macrophage;microbial;Multidrug-Resistant Tuberculosis;Mycobacterium tuberculosis;Necrosis;Oklahoma;Pathogenesis;prevent;Proteins;Siderophores;Therapeutic;Transferrin;tuberculosis granuloma

PROJECT_TITLE: Mechanisms of hemoglobin utilization by Mycobacterium tuberculosis


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Services;Prevention;Primary Health Care;Substance Misuse

ORG_CITY: MIDDLETOWN

ORG_NAME: MOSES-WEITZMAN HEALTH SYSTEM INC

PHR: Project Narrative The proposed project seeks to improve the public's health through its goal of addressing the known research- practice gap in the translation of evidence-based practices in the prevention, screening, and treatment of alcohol use disorder (AUD) and concurrent alcohol/polysubstance use disorders in primary care. By enhancing the capacity of primary care medical and behavioral health providers at federally qualified health centers and safety net settings to utilize this evidence base and provide high quality care, this project ultimately aims to improve health outcomes relating to alcohol use for medically underserved and marginalized populations. Specifically, these efforts align with the National Institute on Alcohol Abuse and Alcoholism's mission statement by supporting providers to apply knowledge on the diagnosis, prevention, and treatment of AUD, as well as simultaneously evaluating and disseminating findings regarding the project's virtual continuing education activities to advance best practices in translating knowledge into primary care practice through inclusive, collaborative, and innovative modalities.

PI_NAMEs: ASHLEY, KAREN  (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Address;alcohol abuse therapy;Alcohol consumption;alcohol use disorder;Alcohols;Attitude;behavioral health;cohort;Continuing Education;design;Development;Diagnosis;Disease;E-learning;Education;Education Projects;Educational Activities;Evaluation;evidence base;Evidence based intervention;Evidence based practice;Familiarity;Federally Qualified Health Center;Funding;Goals;Health;Health Personnel;Health system;Hour;improved;Individual;innovation;interest;Intervention;Journals;Knowledge;Literature;Lived experience;Manuscripts;marginalized population;medically underserved population;meetings;Mission;Modality;Modeling;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;Nurse Practitioners;Outcome;Participant;Patients;Peer Review;Physicians;polysubstance use;prevent;Prevention;Primary Care;primary care practice;primary care provider;primary care setting;primary care team;primary medical care;programs;Provider;Psychologist;Public Health;Quality of Care;Readiness;Recovery;Reporting;Research;research to practice;Resources;response;safety net;Schedule;Science;screening;Self Efficacy;skills;symposium;Translating;Translations;United States;United States Substance Abuse and Mental Health Services Administration;virtual;virtual education;Visit

PROJECT_TITLE: Translating Research into Practice on Alcohol and Polysubstance Use Disorders by Educating the Interprofessional Primary Care Team

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Estrogen;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Female sex hormones contribute to gender differences in many aspects of substance use disorders, such as accelerated transition from casual use to addiction. Synaptic plasticity in dorsal striatal circuits is critical for reward learning and substance use behavior, and this plasticity is impaired by female sex hormones. Understanding how estradiol interacts with cocaine to modify mechanisms underlying synaptic plasticity in the dorsal striatum can illuminate mechanisms underlying gender differences in behavior and help to identify methods for improving treatments in females.

PI_NAMEs: BLACKWELL, KIM L (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Acceleration;addiction;Affect;Animals;Behavior;Behavioral;Brain;cell type;Cells;Cocaine;cocaine related behaviors;cocaine self-administration;cocaine use;Computer Models;Corpus striatum structure;Data;data-driven model;Disparity;Dopamine;Dorsal;Electrophysiology (science);ESR1 gene;Estradiol;Estradiol Receptors;Estrus;experimental study;extracellular;Extracellular Signal Regulated Kinases;Feedback;Female;female sex hormone;Foundations;Future;gender difference;Gene Expression;Gene Expression Profiling;gene interaction;Genetic Complementation Test;Goals;Gonadal Steroid Hormones;habit learning;health disparity;Impairment;improved;innovation;Investigation;Learning;Link;Long-Term Potentiation;male;Mediating;Metabotropic Glutamate Receptors;Methods;Modeling;Molecular;Mus;Neurons;novel;Pathway interactions;Pharmaceutical Preparations;Phosphotransferases;Play;Population;Proteins;Protocols documentation;Publishing;Reduce health disparities;Research;Rewards;Rodent;Role;Saline;Self Administration;sensor;Sex Differences;Signal Pathway;Signal Transduction;single molecule;single nucleus RNA-sequencing;Slice;Specificity;stem;substance use;Substance Use Disorder;Synaptic plasticity;Techniques;Technology;Testing;Time;transcriptomics;Transgenic Mice;Transgenic Organisms;translating ribosome affinity purification and RNA-sequencing;Whole-Cell Recordings;women's treatment;Work

PROJECT_TITLE: Estradiol signaling pathways mediating sex differences in striatal synaptic plasticity

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Teens are at risk for prescription opioid misuse due to easy access to opioids in the home, seeing their friends and parents using opioids incorrectly, not talking to their parents about opioid safety, and lack of educational materials to prevent misuse. A game-based educational tool (MedSMA℞T Mobile) exists that helps teens and parents communicate about opioid medication safety, and this project will make this tool more available in emergency departments (EDs) in Wisconsin and northern Illinois – by (1) changing MedSMA℞T Mobile to fit the needs of individual EDs and their patients, (2) testing whether the MedSMA℞T Mobile tool improves teen/parent opioid misuse knowledge, attitudes, and behaviors, and (3) making the MedSMA℞T Mobile educational tool available in more EDs and getting staff feedback about whether EDs are able to continue to offer it to their patients, while also showing some financial benefits to patient healthcare. This new evidence-based educational game will strengthen families’ knowledge of opioid medication safety risks while also helping them create a personalized medication safety plan, which can reduce teen opioid misuse.

PI_NAMEs: ABRAHAM, OLUFUNMILOLA  (contact)

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: Disseminating and Implementing MedSMA℞T Families in Emergency Departments: A Randomized Control Trial to Assess Effectiveness of an Evidence-Based Gaming Intervention to Reduce Opioid Misuse

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]