NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Arthritis;Autoimmune Disease;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Heart Disease;Neurodegenerative;Neurosciences;Prevention;Rheumatoid Arthritis;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE This application has high public health importance because it will: 1) support mentoring of junior investigators in patient-oriented research (POR) with a focus on the association between systemic inflammation and cognitive decline, thus aligning with the NIA’s mission to “Foster the development of research and clinician scientists in aging’; and 2) define role of inflammation and cardiovascular risk factors in risk of Alzheimer’s disease and related dementias (ADRD), in order to inform risk stratification and future interventions on primary prevention of ADRD. The aims of the application perfectly align with the NIA’s goal of defining the impact of inflammatory processes on the development of AD and are directly relevant to the NIH’s mission to foster innovative research strategies and their applications to protect and improve public health.

PI_NAMEs: MYASOEDOVA, ELENA  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Accounting;Address;Age;age acceleration;age related;Age-associated memory impairment;Aging;aging brain;Alleles;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Anti-Rheumatic Agents;Autoimmune;Autoimmunity;Award;Biological Products;Biometry;C-reactive protein;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career;Characteristics;Chronic;chronic inflammatory disease;Clinic;cognitive performance;cohort;Collaborations;comorbidity;Data;Dementia;dementia risk;Development;Diabetes Mellitus;Disease;disease model;Ensure;Epidemiology;Erythrocyte Sedimentation Rate;Event;Evolution;experience;Extramural Activities;Female;follow-up;Fostering;Funding;Future;Goals;Heart Diseases;Hyperlipidemia;Hypertension;Immune system;immunoregulation;Impaired cognition;improved;Incidence;indexing;Inflammation;Inflammatory;inflammatory marker;Infrastructure;innovation;Intervention;Knowledge;late life;Leadership;Lipids;Longitudinal Studies;Mediating;meetings;men;Mentors;Mentorship;metabolic profile;Mid-Career Clinical Scientist Award (K24);mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;middle age;mild cognitive impairment;Mission;Nervous System Trauma;neuroimaging marker;next generation;novel;Obesity;Older Population;patient oriented;patient oriented research;Patients;Phenotype;Population Attributable Risks;population based;prevent;Prevention;Prevention strategy;Primary Prevention;Process;programs;prototype;Public Health;Publications;Publishing;Research;research and development;Research Infrastructure;Research Personnel;Research Support;Resources;Rheumatism;Rheumatoid Arthritis;Risk;Risk Factors;risk stratification;Role;Scientist;sex;skills;sociodemographics;systemic inflammatory response;tenure track;therapeutic target;Time;United States National Institutes of Health;vascular cognitive impairment and dementia;Woman

PROJECT_TITLE: Temporal associations between systemic inflammation, cardiovascular risk profile and development of Alzheimer’s disease and related dementias in patients with rheumatoid arthritis

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: The proposed studies will investigate the role of a cyclooxygenase-2/PGE2 axis to mediate macrophage and neutrophil responses to acute ischemic kidney injury. The studies will investigate mechanisms by which innate immune cells interact to exacerbate acute kidney injury and the mechanisms by which they mediate regeneration of the intrinsic kidney cells.

PI_NAMEs: HARRIS, RAYMOND C. (contact);ZHANG, MINGZHI

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acceleration;Acute;Acute Renal Failure with Renal Papillary Necrosis;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Arachidonic Acids;Area;autocrine;Cell Communication;Cells;chemokine;Communities;cyclooxygenase 2;cytokine;Detection;Diabetic Nephropathy;Dinoprostone;Disparate;Enterobacteria phage P1 Cre recombinase;Enzymes;Event;Extracellular Matrix;Fibrosis;Goals;Hour;Immune;Inflammation;Inflammation Mediators;Inflammatory;Injury;Injury to Kidney;Innate Immune System;Investigation;Ischemia;ischemic injury;Kidney;kidney cell;lipid mediator;Lipoxins;Macrophage;Mediating;Metabolism;Methodology;migration;Modeling;monocyte;Myelogenous;Natural regeneration;neutrophil;Neutrophil Activation;Neutrophil Infiltration;pharmacologic;Phase;Phenotype;Play;Pleurisy;prevent;Process;Prostaglandin E Receptor;Prostaglandin-Endoperoxide Synthase;Prostaglandins;Recovery;Regulation;renal ischemia;repaired;Reperfusion Therapy;Reporting;Resolution;response;Role;Sterility;System;Tissues;WFDC2 gene

PROJECT_TITLE: Role of  the innate immune system in acute kidney injury

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Soft tissue sarcomas are malignant tumors that grow in soft tissues like fat, muscle, cartilage, or deep skin tissues. There are also benign soft tissue tumors affecting a much larger number of patients. The goal of this project is to develop a novel ultra-steerable histotripsy array system for non-invasive treatment of malignant and benign soft tissue tumors in both adults and children.

PI_NAMEs: XU, ZHEN  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3-Dimensional;Ablation;Acceleration;Acoustics;Adult;Affect;American Cancer Society;Amputation;Anatomy;Animal Model;Animals;Area;arm;Benign;Blood Vessels;Body part;bone;Burn injury;cancer care;Cancer Center;Canis familiaris;Cartilage;Cells;Cessation of life;chemotherapy;Child;clinical translation;Coupling;Data;design;design and construction;Development;Ensure;Excision;Fatty acid glycerol esters;fibrosarcoma;Focused Ultrasound Therapy;Follow-Up Studies;Future;Goals;Histologic;Human;image guided;improved;in vivo;in vivo evaluation;individualized medicine;invention;Laboratories;Leg;liposarcoma;Longterm Follow-up;Malignant - descriptor;Malignant Neoplasms;Mechanics;Mesenchymal;Methods;Michigan;minimally invasive;Monitor;Muscle;NCI Center for Cancer Research;Nerve;neurovascular;non-invasive system;novel;Operative Surgical Procedures;patient subsets;Patients;Phase;Physiology;preservation;Procedures;Property;prototype;Radiation;Radiation therapy;Recurrence;Reporting;Resected;Risk;Robotics;Safety;safety and feasibility;safety testing;Sampling;Skin;Skin Tissue;soft tissue;Soft Tissue Neoplasms;Soft tissue sarcoma;Speed;Structure;Subcutaneous Tissue;Surface;System;Testing;Thermal Ablation Therapy;Time;Tissues;Toxic effect;transmission process;treatment strategy;tumor;Tumor Debulking;Ultrasonic Therapy;Ultrasonography;ultrasound;Universities;Unresectable;Virginia

PROJECT_TITLE: Ultrasound-guided Ultra-steerable Histotripsy Array System for Non-invasive treatment of Soft Tissue Sarcoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-J(03)M]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome;Nutrition;Pediatric;Prevention

ORG_CITY: BIRMINGHAM

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The proposed interdisciplinary research is relevant to public health because Cytomegalovirus (CMV) is a significant opportunistic pathogen that can cause severe illness in newborns and immunocompromised individuals. Transmission via human milk (HM) has been recognized to have the largest global impact on population prevalence and, therefore, a research program will be undertaken to study HM CMV transmission dynamics in different timescales, systematically and quantitatively understand the role and interactions of the HM metabolome and microbiome in CMV transmission from women to their infants, validate factors blocking CMV transmission, and evaluate the impact of CMV transmission to the establishment and development of infant gut microbiota. Our findings will deepen our understanding of CMV transmission dynamics, provide a framework for translation assisted by mathematical models and artificial intelligence, and will lay the foundation for rational design of personalized interventions through naturally occurring HM microbiota and metabolites.

PI_NAMEs: MARQUEZ-LAGO, TATIANA T. (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Age Months;Anti-viral Agents;Antibodies;Artificial Intelligence;Bile Acids;Biomedical Engineering;blocking factor;blood group;Blood typing procedure;Body Fluids;Caring;Cells;Child;Chromatography;Chronic;Clinical;Coculture Techniques;cofactor;commensal microbes;Communities;comparative;congenital infection;Cytomegalovirus;Data;density;Dimensions;disability;Disease;Ecology;Epithelial Cells;Etiology;Exposure to;Fatty Acids;Fermentation;Foundations;Gender;Goals;gut microbiota;Human;Human Microbiome;human microbiota;Human Milk;human milk oligosaccharides;Immune response;Immune system;Immunocompromised Host;improved;Individual;Infant;Infant Development;Infection prevention;insight;Interdisciplinary Study;Intervention;Investigation;Lactation;Licensing;Life;machine learning prediction;Maps;Maternal Age;mathematical model;Measures;Medium chain fatty acid;Metabolism;metabolome;metabolomics;Metagenomics;metatranscriptomics;microbial;microbial products;microbiome;microbiota;milk microbiome;Modeling;Molecular;Mothers;multiple omics;Newborn Infant;non-genetic;offspring;opportunistic pathogen;Passive Immunization;pathogenic virus;Pattern;personalized intervention;Population;predictive modeling;Prevalence;prevent;programs;Public Health;rational design;receptor;Reproducibility;Research;Resources;Risk;risk mitigation;Role;Saliva;saliva sample;Sampling;seropositive;Shotguns;Site;stool sample;Supplementation;tandem mass spectrometry;Testing;Time;Tissues;tool;Translating;translational framework;Translations;transmission process;Urine;Vaccines;Viral Antibodies;Viral Load result;viral transmission;Virus Diseases;Virus Shedding;Woman

PROJECT_TITLE: Blocking CMV transmission through the human milk metabolome and microbiome

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LONG BEACH

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA STATE UNIVERSITY LONG BEACH

ORG_STATE: CA

PHR: The goal of the CSULB U-RISE Program is to increase diversity in biomedical research by providing enhanced academic and research training opportunities, and workshops on professional/leadership skills to underrepresented/underserved (UR/US) students. The objective is to increase the number of UR/US students entering and succeeding in graduate programs in biomedical areas.

PI_NAMEs: NARAYANASWAMI, VASANTHY  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Academic skills;Administrator;Adopted;Asian Americans;Attenuated;Biomedical Research;California;career;CCL7 gene;Classification;Collaborations;Communication;Critical Thinking;design;Development;Discipline;Doctor of Philosophy;Education;Eligibility Determination;Environment;equity, diversity, and inclusion;experience;Extramural Activities;Faculty;faculty mentor;Feedback;Fostering;Funding;Future;Goals;Graduate Degree;graduate school;graduate school preparation;Growth;higher education;Hispanic-serving Institution;Human Resources;Individual;innovation;Institution;interest;Intervention;Intramural Research;Journals;Leadership;learning community;Left;Manuscripts;meetings;member;Mentors;minority student;Mission;Names;Native Americans;Outcome;Pacific Islander;Peer Review;Preparation;Privatization;Problem Solving;programs;Publications;Reading;recruit;Research;Research Activity;Research Methodology;Research Personnel;Research Training;resilience;responsible research conduct;Scientist;skill acquisition;skills;social;socioeconomics;stem;student training;Students;symposium;System;Training;Training Programs;undergraduate research;undergraduate student;Underrepresented Students;underserved students;United States National Institutes of Health;Universities;Urban Population;Work

PROJECT_TITLE: Undergraduate Research Training Initiative for Student Enhancement (U-RISE) (T34) at CSULB

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: BURLINGTON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE Each year lung cancer kills more people in the United States than breast, colorectal and prostate cancer combined. Immunotherapies, including anti-PD-1 monoclonal antibodies, may reduce lung cancer morbidity and mortality, but we can’t yet accurately predict which patients will benefit. The goal of this work is to delineate the molecular mechanisms linking STK11 loss with anti-PD-1 therapy resistance in KRAS-driven lung adenocarcinoma and exploit that knowledge to restore sensitivity to current therapies while working to identify new treatment strategies.

PI_NAMEs: SEWARD, DAVID JOSEPH (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Alleles;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;Award;Biological Markers;Cancer cell line;Cancer Patient;career;catalyst;Cell Line;Cells;Clinical Research;Colorectal Cancer;Critical Pathways;cytokine;Cytokine Signaling;Data Set;Dedications;Development;FDA approved;Flow Cytometry;Gene Expression Profile;Gene set enrichment analysis;Genetic Transcription;Genetically Engineered Mouse;Genotype;Goals;Grant;Histologic;Human;IL8 gene;Immune;Immune checkpoint inhibitor;Immune response;Immunocompetent;Immunotherapeutic agent;Immunotherapy;in vivo;inhibitor;Interleukin-2;interleukin-23;Interleukin-6;K-ras mouse model;Knowledge;KRAS2 gene;KRASG12D;Leukocytes;Link;loss of function;Lung;Lung Adenocarcinoma;lung cancer cell;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Modeling;Molecular;Monitor;Monoclonal Antibody Therapy;Morbidity - disease rate;mortality;mouse model;Mus;Mutate;Mutation;Neoplasm Metastasis;neoplastic cell;NF-kappa B;novel therapeutic intervention;Organ Size;Outcome;Patients;Persons;Phenotype;Physicians;Production;Prognosis;programs;Protein-Serine-Threonine Kinases;Proteins;recruit;Regulation;Reporter;Reporting;Research;research and development;Resistance;responders and non-responders;response;Scientist;Serine;Signal Transduction;Sorting;Technology;Testing;therapeutic target;therapy development;TNF gene;Tomatoes;transcription factor;transcriptome;transcriptome sequencing;treatment response;Triage;tumor;Tumor Burden;tumor microenvironment;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumor-immune system interactions;United States;Up-Regulation;Verteporfin;Work

PROJECT_TITLE: STK11 loss of function and anti-PD-1 therapy resistance in KRAS-driven lung adenocarcinoma


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The need to understand the functions of rare somatic mutations calls for multi-OMIC technologies that can scan somatic mutations and map epigenome simultaneously. Here we will optimize a method to generate both whole genome sequencing and 3D genome (Hi-C) data from single cells. Using a novel deep-learning-based pipeline, we can upgrade the sparse Hi-C maps to kilobase resolution, which serves as a robust readout for genome activity.

PI_NAMEs: JIN, FULAI  (contact);LI, YAN

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: 3-Dimensional;Address;Affect;ATAC-seq;autism spectrum disorder;Benchmarking;Biotin;bisulfite sequencing;Catalogs;Cell division;Cell Line;Cell model;Cell Physiology;cell type;Cells;ChIP-seq;Clonal Expansion;Complex;Copy Number Polymorphism;Data;deep learning;Detection;Development;Disease;DNA;DNA Methylation;DNA Sequence Alteration;DNA sequencing;epigenome;epigenomics;experimental study;feasibility testing;Funding;Genetic;Genome;Genome Mappings;genome sequencing;Genomics;Genotype;Germ Lines;Hi-C;Human;human tissue;improved;Islet Cell;Islets of Langerhans;Joints;Lead;Libraries;Ligation;Malignant Neoplasms;Maps;Methods;Molecular;Mosaicism;multiple omics;Mutation;Names;Nature;Neurons;Normal Cell;novel;Paper;Phase;Play;Population;Positioning Attribute;Protocols documentation;Publishing;rare variant;Research;Resolution;Role;scale up;Scanning;Shotguns;Single Nucleotide Polymorphism;Somatic Cell;Somatic Mutation;Technology;Testing;Time;Tissue Sample;Tissues;tool;transcriptomics;Variant;whole genome

PROJECT_TITLE: Simultaneous mapping of somatic mosaicism and kb-resolution 3D genome in single cells.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-K(70)R]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: NARRATIVE The proposed research seeks to expand the scope of chimeric antigen receptor (CAR) T cell therapy against glioblastoma (GBM) by using the tumor-specific targeting capabilities inherent in chlorotoxin (CLTX) to redirect T cells against GBM. CLTX-CAR T cells are expected to broadly target heterogeneous GBM populations and be safe and well tolerated, with negligible activity against normal tissues. The proposed clinical trial aims to improve our understanding of tumor response to therapeutic pressure and key drivers of response and resistance to CAR T cell therapy, with the goal of improving outcomes of patients with GBM.

PI_NAMEs: BADIE, BEHNAM ;BROWN, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;Adoptive Transfer;Amino Acids;Antibodies;Antigens;antitumor effect;Autologous;B lymphoid malignancy;Binding;Blood;Brain;Brain Neoplasms;cancer cell;CAR T cell therapy;Catheters;CD19 gene;Cells;Central Nervous System;Cerebrospinal Fluid;Characteristics;chimeric antigen receptor;chimeric antigen receptor T cells;Chlorotoxin;Cities;Clinic;Clinical;clinical outcome assessment;Clinical Research;clinical translation;Clinical Trials;Coupled;cross reactivity;Cyst Fluid;cytokine;Data;design;Disease;Disease remission;early phase clinical trial;Evolution;experience;first-in-human;Future;Gene Expression;Glioblastoma;Goals;Hematologic Neoplasms;Heterogeneity;Human;Image;Immune;Immunologic Monitoring;Immunologics;Immunotherapy;improved;improved outcome;in vitro activity;in vivo;Individual;Inflammatory;innovation;Investigational New Drug Application;Letters;Ligands;Maximum Tolerated Dose;Mediating;Medical;Modality;Monitor;mouse model;Nature;neoplasm immunotherapy;neoplastic cell;Non-Malignant;Normal tissue morphology;novel;novel therapeutics;Organ;Outcome;Participant;Pathway interactions;patient prognosis;patient response;Patient-Focused Outcomes;Patients;Peptides;Phase I Clinical Trials;phase I trial;Phenotype;Population;Positioning Attribute;preclinical study;pressure;Prognosis;programs;Property;protein expression;Radiation therapy;Recurrence;Recurrent tumor;Research;research clinical testing;Resistance;response;Safety;Sampling;Scorpion Venoms;Scorpions;Solid Neoplasm;standard of care;success;Surface Antigens;Surrogate Markers;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Therapeutic;therapy resistant;Time;treatment response;tumor;Tumor Antigens;tumor eradication;Tumor Expansion

PROJECT_TITLE: Clinical Evaluation of Chlorotoxin-redirected Chimeric Antigen Receptor (CAR) T cells for Treatment of Glioblastoma

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Autosomal dominant polycystic kidney disease (ADPKD) is affects 1/400-1/1000 and is caused mutations in PKD1 and PKD2, which encode polycystin proteins. This competing renewal application will uncover the functions of the polycystins on cilia and tiny extracellular vesicles. Our studies will provide insight about the biology of normal and pathological processes that require or are modulated by extracellular vesicles including ADPKD.

PI_NAMEs: BARR, MAUREEN M (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Address;Affect;Afferent Neurons;Animal Communication;Animals;Architecture;Attenuated;Autosomal Dominant Polycystic Kidney;base;Biochemical;Biogenesis;Biological Markers;Biological Process;Biology;Biotin;Caenorhabditis elegans;Cell Physiology;cell type;Cilia;ciliopathy;Cloning;combat;CRISPR/Cas technology;Defect;delivery vehicle;Deposition;design;Disease;Engineering;Enzymes;extracellular vesicles;G-Protein-Coupled Receptors;gene product;Genes;Genetic;Goals;Grant;Health;Hermaphroditism;Human;in vivo;insight;intercellular communication;Kidney;Kidney Diseases;Label;Life;Ligase;Location;male;Mammals;Mechanical Stimulation;Medical;model organism;Modeling;Molecular;Mutagenesis;Mutation;Nematoda;Neuroglia;Neurons;novel;Partner in relationship;Pathogenicity;Pathologic Processes;Pathway interactions;Physiological;PKD2 protein;Play;polycystic kidney disease 1 protein;prevent;protein function;Proteins;Proteolysis;Proteome;real-time images;Reporter;Role;Sensory;Signal Pathway;Signal Transduction;Site;Sorting;System;Testing;therapeutic target;trafficking;ultra high resolution;urinary;variant of unknown significance;Vulva

PROJECT_TITLE: Polycystins, cilia, and extracellular vesicles in C. elegans

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Image distortions degrade the accuracy and sensitivity of detecting brain activity with functional magnetic resonance imaging (fMRI). This project aims to develop a novel method based on deep learning to correct for fMRI image distortions. This method can restore distortion-free images from measured MRI signal in k-space by incorporating the physical model of distortion effects with deep learning networks. This proposal will resolve a long-standing problem in fMRI, facilitating its applications in neuroscience, patient care, and other areas.

PI_NAMEs: LUO, QINGFEI  (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: Acute;Adopted;Algorithms;analytical method;anatomic imaging;Anatomy;Architecture;Area;Brain;brain control;Brain Mapping;Brain region;Chicago;chronic pain;clinical application;cognitive neuroscience;Compensation;Complex;convolutional neural network;Data;Data Collection;data space;Databases;deep learning;deep learning algorithm;detection sensitivity;executive function;Exhibits;frontal lobe;Functional Magnetic Resonance Imaging;functional MRI scan;Funding;Goals;Illinois;Image;image reconstruction;image registration;Individual;Lead;Learning;learning network;loss of function;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Measures;Methods;Modeling;Morphologic artifacts;Neurosciences;novel;novel strategies;Patient Care;Performance;Phase;physical model;Physics;Random Allocation;reconstruction;Research;Residual state;Resolution;Scanning;Signal Transduction;Site;Techniques;Testing;Time;Tissues;tool;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: Distortion Correction in Functional MRI with Deep Learning

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Co-infection with HIV is one of the most common risk factors for developing tuberculosis (TB) and so we model HIV and M. tuberculosis (Mtb) co-infection in monkeys, using simian immunodeficiency virus (SIV) as an HIV surrogate, to study this. Our exciting preliminary data suggests that vaccinating SIV+ animals with intravenous Bacille Calmette-Guerin (BCG IV) confers remarkable protection from TB. Here, we will further evaluate BCG IV to better refine this vaccine regimen and to identify the mechanism of this striking protection.

PI_NAMEs: SCANGA, CHARLES A. (contact)

PROGRAM_OFFICER_NAME: DANG, QUE

PROJECT_TERMS: Adult;aerosolized;Animals;Anti-Retroviral Agents;Antimycobacterial Agents;antiretroviral therapy;ATAC-seq;Attenuated;BCG Live;Bronchoscopes;Chest;Childhood;Chronic;Clinical Trials;co-infection;Collaborations;Country;Data;Development;Disease;Dose;Drug resistance in tuberculosis;Ensure;Epigenetic Process;Exhibits;Flow Cytometry;Genus Mycobacterium;global health;Goals;HIV;HIV Infections;HIV/TB;Immune;Immunity;Immunocompromised Host;immunogenic;Immunologics;improved;Individual;Infant;Infection;insight;Intention;Intervention;Intravenous;Learning;Licensing;Lung Diseases;Macaca;Macaca fascicularis;Macaca mulatta;Mediating;Modeling;Monkeys;mortality;multidisciplinary;Mycobacterium bovis;Mycobacterium tuberculosis;Newborn Infant;nonhuman primate;Pathogenicity;Persons;Pharmaceutical Preparations;Population;Predisposition;prevent;Productivity;Pulmonary Tuberculosis;Recording of previous events;Regimen;Rhesus;Risk Factors;Risk Reduction;Route;Safety;Sampling;Serology;Signal Transduction;single-cell RNA sequencing;SIV;System;Technology;Testing;Time;Training;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;United States;Vaccinated;Vaccination;vaccination against tuberculosis;vaccination strategy;Vaccines;Virulent;Virus Diseases;Vulnerable Populations

PROJECT_TITLE: Preventing TB with intravenous BCG in SIV-infected macaques


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Prevention

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE This project offers a brand-new paradigm on Crohn’s disease (CD)-associated intestinal strictures that will on the short term delve into novel cellular and molecular mechanisms of intestinal stricture formation and on the long-term will eventually foster the development of specific new drugs. Thus, this proposal is directly relevant to IBD and the goals of the National Institute of Health by benefitting more than half of Crohn’s disease (CD) patients and having a tangible impact on ways to prevent intestinal obstruction and avoid surgical resections. By investigating a previously unidentified role of the septin cytoskeleton inhibiting pro-fibrotic intestinal myofibroblast activation in vitro and in vivo, we will deviate from the traditional notion of immune cell-driven ECM deposition, and instead focus on the cytoskeleton being responsible for fibrosis and stricture formation.

PI_NAMEs: IVANOV, ANDREI IVANOVICH;RIEDER, FLORIAN  (contact)

PROGRAM_OFFICER_NAME: KLAPPROTH, JAN-MICHAEL AXEL

PROJECT_TERMS: Acceleration;Actomyosin;Affect;Animal Model;Anti-Inflammatory Agents;antifibrotic treatment;Atlases;Attenuated;Automobile Driving;Binding;Biology;Cell Differentiation process;cell motility;Cell Physiology;Cells;Collagen;Complex;Complication;Crohn's disease;Cytoskeletal Proteins;Cytoskeleton;Data;Deposition;Development;Disease;Disease Progression;Effector Cell;Endocytosis;Excision;Exposure to;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;fibrogenesis;Fibronectins;Fibrosis;Filament;Flagellin;Fostering;gain of function;Gene Expression;Generations;Genetic;genetic approach;Genetic Induction;Goals;Growth Factor;GTP-Binding Proteins;gut inflammation;Health Benefit;Human;Immune;improved;In Vitro;in vivo;Incidence;Inflammation;Intestinal Fibrosis;Intestinal Obstruction;Intestines;Investigation;Link;loss of function;LoxP-flanked allele;Maps;Mediating;Membrane;Microfilaments;migration;Molecular;Motor;mouse model;Mus;Myofibroblast;Myosin ATPase;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Organ;Organelles;overexpression;Patients;pharmacologic;Phenotype;Polymers;posttranscriptional;prevent;Prevention;Production;Property;Protein Isoforms;Proteins;Receptor Signaling;Regulation;Resolution;Role;scaffold;self assembly;Signal Transduction;single-cell RNA sequencing;Small Interfering RNA;Structure;Testing;therapeutically effective;Thick;Tissue Sample;Tissues;trafficking;Transforming Growth Factors;Translations;translatome;United States National Institutes of Health;Up-Regulation;Vesicle

PROJECT_TITLE: Septins in intestinal fibrosis

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lymphatic Research;Lymphedema;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Despite the improvements in breast cancer survival, black women experience suboptimal quality of life, which is why it is important to evaluate their experiences to improve quality of life (QOL) and target healthy behaviors that foster a longer life among racial/ethnic minority breast cancer survivors. Physical activity (PA) is a modifiable behavior with the potential to help reduce racial disparities in QOL. This fellowship will help to establish the relationship between PA and QOL among black women, generate new knowledge and insights to enhance QOL among black women, cultivate community partnerships, and empower other researchers to increase the representation of racial/ethnic minorities in studies focusing on behavioral medicine to meet the needs of this community.

PI_NAMEs: BURSE, NATASHA RENEE (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Aerobic Exercise;Affect;Aftercare;Awareness;Behavior;Behavior Therapy;Behavioral;Behavioral Medicine;Black race;black women;Body Composition;Body Image;Body Weight decreased;Breast Cancer Risk Factor;breast cancer survival;Breast Cancer survivor;Cancer Death Rates;cancer diagnosis;Cancer Etiology;Cancer Survivor;cancer therapy;cancer type;Caring;clinical practice;Communities;community partnership;Control Groups;design;Development;Diagnosis;Disease;Disparity;effective therapy;Emotional;empowerment;Enrollment;ethnic minority;Exercise;exercise intervention;exercise program;experience;Failure;Fatigue;Fellowship;Fostering;Health;Health behavior;health organization;Health Professional;improved;Incidence;Individual;insight;Intervention;Interview;Knowledge;Life;Life Experience;Lymphedema;Malignant Breast Neoplasm;Measures;Medical;Methods;modifiable behavior;Obesity;obesity risk;optimal treatments;Outcome;Overweight;Pain;Pennsylvania;Perception;Personal Satisfaction;Physical activity;physical inactivity;Physicians;poor health outcome;Population;Postdoctoral Fellow;primary outcome;programs;Psyche structure;Quality of life;quality of life for cancer survivors;Questionnaires;racial disparity;racial minority;Randomized, Controlled Trials;Recommendation;Recording of previous events;Research;Research Personnel;Research Project Grants;Resources;Risk Reduction;Scientific Advances and Accomplishments;Sex Functioning;sleep quality;social;social health determinants;Social Well-Being;Socioeconomic Factors;Spiritual well-being;Spirituality;strength training;Structure;Surveys;Survival Rate;Survivors;survivorship;Swelling;Target Populations;Technology;Time;Training;treatment effect;Tumor Biology;United States;Walking;Weight;weight loss intervention;Well in self;White Women;Woman;Women's Health;Women's mortality

PROJECT_TITLE: Understanding Quality of Life and Physical Activity in Black Breast Cancer Survivors


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Human Genome;Prevention

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: Project Narrative While the poorly understood age-related factors promoting cardiovascular disease (CVD) risk require urgent investigation as the population ages, recent data establish CVD as the primary cause of the increased mortality in those with clonal hematopoiesis of indeterminate potential (CHIP), which is common in elders (≥1 in 10 among >70 years). The aims of this proposal will: discover the germline genetic predisposition that induces CHIP-related CVD with N~575K to construct CHIP-specific polygenic interaction risk score (PIRS) for CVD, which stratify the risk of CVD in CHIP carriers (K99/Aim 1 and R00/Aim 3), prioritize causal mechanisms for CHIP-related coronary artery disease (CAD), which is the major cause of CVD, with integrating genomic data and multi-omics data (K99/Aim 2), and dissect the molecular mechanisms for CHIP-related CAD analyzing human specimens and combining with population genetics (R00/Aim 4). Successful completion of this study will directly improve the management of CVD risks in CHIP carriers by PIRS and pave the way for developing direct intervention by revealing mechanisms.

PI_NAMEs: NAKAO, TETSUSHI  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Address;Affect;Age;age related;Alleles;Award;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career;causal variant;Cause of Death;Cells;Cessation of life;Chromosomes;Clinical Management;Coronary Arteriosclerosis;Data;Development;Disease;Disease Management;disorder risk;DNMT3a;efficacious treatment;Elderly;Environment;Epidemiology;Etiology;experience;functional genomics;Gene Expression;gene interaction;Genes;Genetic;genetic analysis;Genetic Predisposition to Disease;Genetic study;genetic variant;genome-wide;genomic data;Genomics;Genotype;Germ Lines;hazard;Heart failure;Hematology;Hematopoiesis;Hematopoietic stem cells;Human;Human Genetics;human genomics;IL6 Signaling Pathway;improved;in silico;Individual;Inflammatory;Interleukin 6 Receptor;Interleukin-1 beta;Interleukin-6;Intervention;Investigation;JAK2 gene;Knowledge;large datasets;Leukocytes;Link;Mediation;medical schools;Medicine;member;Mendelian randomization;Mentors;Mentorship;Molecular;Molecular Analysis;mortality;Multiomic Data;multiple omics;Mutation;novel;novel strategies;older adult;Pathogenesis;Pathway interactions;Patients;Penetrance;Peripheral arterial disease;Population;Population Analysis;Population Genetics;posttranscriptional;pre-clinical;premature;Prevention strategy;pro-aging;Proliferating;Property;Proteins;Proteome;Quantitative Trait Loci;receptor expression;Research;Research Personnel;Resources;Risk;Risk Assessment;Risk Management;risk stratification;risk variant;Role;Sample Size;single-cell RNA sequencing;skills;Specificity;Specimen;Stroke;Testing;Training;Transcript;transcriptome;translational applications;translational medicine;Translational Research;Variant;Vocational Guidance

PROJECT_TITLE: Using genomic modifiers to mechanistically link clonal hematopoiesis of indeterminate potential penetrance to coronary artery disease

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(JA)]


ORG_CITY: OMAHA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Narrative Superoxide dismutase (SOD) enzymes are essential to life and reduce the level of reactive oxygen species in cells. Abnormal SOD activity is found in many pathologies, such as cancer, neurodegenerative diseases, and cardiovascular dysfunction. To provide a detailed understanding of SOD in diseases and for the design of therapeutic interventions, our investigation seeks to define the atom-by-atom workings of the group of enzymes for the first time.

PI_NAMEs: BORGSTAHL, GLORIA  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: 3-Dimensional;Active Sites;Amino Acids;Antioxidants;Binding;Biological Process;Biology;Bypass;Cardiovascular system;Cells;Charge;Complex;computational chemistry;Coupled;Coupling;Crystallography;Data;Data Collection;design;Dioxygen;Disease;Electron Transport;Electronics;Electrons;Electrostatics;Environment;Enzymatic Biochemistry;Enzymes;experimental study;Functional disorder;Future;Goals;Homeostasis;Human;Hydrogen;Hydrogen Peroxide;improved;interest;Investigation;ionization;Laboratories;Life;Ligand Binding;Ligands;Malignant Neoplasms;Manganese;Maps;Measures;Metabolic;metalloenzyme;Metals;Methods;Mitochondria;Mitochondrial Matrix;Modeling;Molecular;Nature;Neurodegenerative Disorders;Neutron Diffraction;Neutrons;novel strategies;Organism;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;Oxygen;Pathology;Periodicity;Positioning Attribute;prevent;Proteins;Protocols documentation;protonation;Protons;Reaction;reaction rate;Reactive Oxygen Species;Research;Research Project Grants;Rest;Role;Signal Transduction;SOD2 gene;Solvents;Spectrum Analysis;structural biology;Structure;Superoxide Dismutase;Superoxides;Surface;System;Testing;Therapeutic;Therapeutic Intervention;Time;tool;Variant;Visualization;Water;working group;X-Ray Crystallography

PROJECT_TITLE: Deciphering the Enzymatic Mechanism of Superoxide Dismutase

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE A growth in the aging population together with improved stroke care has resulted in an increase in survivors and a rise in recurrent ischemic events. Ischemic preconditioning has been shown to effectively protect neurons, while mechanisms of preconditioning in white matter remain to be studied even though axonal injury during stroke underlies the consequent neurological disability in surviving patients. We propose that inhibiting CK2 using an FDA-approved drug, CX-4945 (Silmitasertib), rapidly preconditions WM against ischemia by targeting axonal mitochondria and improving functional recovery in young and old WM both in males and females.

PI_NAMEs: BALTAN, SELVA  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: 3-Dimensional;Age;Aging;aging population;AKT Signaling Pathway;artery occlusion;Attenuated;Axon;axon injury;Behavior assessment;Behavioral;behavioral outcome;Bioinformatics;Brain;Brain Hypoxia-Ischemia;Cancer Patient;Caring;casein kinase II;Cause of Death;CDK5 gene;Clinical;clinical application;Clinical Research;clinically relevant;Common carotid artery;Correlation Studies;Cyclic AMP-Dependent Protein Kinases;Data;disability;Electron Microscopy;Electrophysiology (science);Event;experimental study;FDA approved;Female;Functional disorder;Funding;Genus Hippocampus;Goals;gray matter;Growth;Guanosine Triphosphate Phosphohydrolases;health care economics;healthcare burden;high risk;Human;Image;improved;In Vitro;in vivo;in vivo Model;inhibitor;Ischemia;ischemic injury;Ischemic Preconditioning;male;Mediating;MicroRNAs;Mitochondria;Mitochondrial Proteins;Modeling;Motility;Mus;Neurological disability;Neurons;novel;Oligodendroglia;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Plasma;preconditioning;preservation;protective effect;Proto-Oncogene Proteins c-akt;Recovery of Function;Recurrence;Regulation;Reporting;Risk;Rodent;Role;Sampling;sex;Signal Transduction;Signaling Molecule;spatiotemporal;Stroke;stroke event;stroke patient;stroke survivor;Structure;subcortical ischemic vascular disease;Survivors;Testing;Therapeutic;therapeutic target;trafficking;Translating;Up-Regulation;Validation;white matter;white matter injury;White Women

PROJECT_TITLE: Preconditioning brain white matter against ischemia

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Contraception/Reproduction

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE Aging in the gonad dramatically affects aging in somatic tissues, yet we know little about the mechanisms regulating healthy aging in reproductive organs, nor how this crosstalk is achieved. The goal of the Reproductive Aging Conference will be to showcase research in the growing field of reproductive aging in both male and female systems and stimulate collaborations across disciplines that will help define new paradigms. This unique meeting brings together experts from both academic and clinical science, junior investigators, and trainees to examine mechanisms that regulate aging in reproductive tissues that facilitate overall health span and longevity.

PI_NAMEs: GARRISON, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acceleration;Address;Affect;Age;Aging;Area;Attitude;Award;Biological Models;Biology;Biology of Aging;California;cancer type;Cardiovascular system;career;Cell Aging;Clinical;Clinical Sciences;Collaborations;Communication;Creativeness;Data;Dedications;Development;Discipline;Education;Elderly;Emerging Technologies;Ensure;Environmental Risk Factor;Faculty;Feedback;Female;Fertility;Fostering;Funding;Future;Genetic;Germ Cells;Goals;Gonadal structure;Health;healthspan;healthy aging;Human;improved;interest;International;lectures;Libido;life span;Longevity;male;meetings;men;Metabolic;minority trainee;Modeling;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Nature;new technology;next generation;Oral;Outcome;Participant;Performance;Physiological Processes;Postdoctoral Fellow;posters;Property;Regulation;Reproduction;reproductive;Reproductive Biology;reproductive organ;Reproductive Sciences;reproductive senescence;Reproductive system;reproductive tract;Request for Applications;Research;Research Personnel;Resort;Resource Sharing;Resources;Rest;Role;Scholarship;Science;Scientist;senescence;Senior Scientist;sexual dimorphism;Shapes;skeletal;skills;Somatic Cell;Students;symposium;synergism;System;Therapeutic;Tissues;training opportunity;Travel;undergraduate student

PROJECT_TITLE: The Reproductive Aging Conference

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: KIKUYU

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: BIOTECHNOLOGY RESEARCH INSTITUTE-KALRO

PHR: Research is needed to develop effective responses to vector-borne Neglected Tropical Diseases in sub-Saharan Africa. This grant will allow scientists from East Africa [Kenya Agriculture and Livestock Research Organization (BioRI-KALRO), Kenya Medical Research Institute (KEMRI) in Kenya and Gulu University in Uganda], and their Yale University collaborators, to train early career scientists in fundamental principles of vector biology and vector borne diseases and in new and emerging translational technologies for vector control. Program described in this application contains a mix of postdoctoral training for junior academicians/practitioners and thematic workshops and courses to enhance research capacity in vector biology and advance enhance vector control.

PI_NAMEs: AKSOY, SERAP ;MIREJI, PAUL O (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Address;Administrator;Adoption;Africa;Africa South of the Sahara;African;Agriculture;Animals;Award;Bioethics;Biology;Biotechnology;burden of illness;career;Clinical;Consultations;Country;data management;Disease;Ecology;editorial;Education;Educational workshop;empowerment;Environmental Health;Epidemiology;evidence base;Faculty;Genomics;Human;innovation;Institution;institutional capacity;Kenya;Knowledge;Laboratories;Leadership;Livestock;low and middle-income countries;Manuscripts;mathematical model;Medical Research;Mentorship;neglected tropical diseases;next generation;Output;Participant;peer;Persons;Physiology;Policy Maker;Population Genetics;Postdoctoral Fellow;Practice Management;Preparation;programs;Public Health;Public Health Schools;Research;research and development;Research Institute;Research Personnel;Science;Scientist;skills;Tanzania;Teacher Professional Development;Technology;Training;training opportunity;Uganda;Universities;vector;vector control;vector management strategies;vector-borne;Vector-transmitted infectious disease;virtual;webinar

PROJECT_TITLE: Support for Vector Biology Training for Sustainable Control of Vector Borne diseases in East Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(55)]


ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative We discovered a robust anabolic response in human cartilage that follows a distal-proximal axis gradient (high in the ankle joint and low in the hip joint); this response was modulated by the same master regulators that regulate limb regeneration in animals capable of limb regeneration. This project investigates the origins of these master regulators in synovial cells, the mechanisms involved, and how aging effects these mechanisms in human joint tissue.

PI_NAMEs: HSUEH, MING-FENG  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Age;age effect;age related;Aging;aging population;Animal Model;Animals;Ankle;ankle joint;appendage;Area;Arthritis;Award;Bioinformatics;Biology of Aging;Biometry;career;career development;Cartilage;Cell Separation;cell type;Cells;chronic pain;Clinical Trials;Colon;complex data;Data;Data Analyses;Data Set;Degenerative Disorder;Degenerative polyarthritis;Development;Development Plans;Distal;Educational Status;Educational workshop;Environment;Fibroblasts;fighting;Future;Gene set enrichment analysis;Goals;Health;Hip Joint;Hip region structure;Homeostasis;Human;improved;improved outcome;Incidence;Injury;injury and repair;joint destruction;joint inflammation;joint injury;Joints;Knowledge;limb regeneration;Macrophage;Mediating;meetings;Mentored Research Scientist Development Award;Mentors;Mentorship;MicroRNAs;Molecular;Morbidity - disease rate;Musculoskeletal;Natural regeneration;neutrophil;novel;novel therapeutic intervention;older adult;Older Population;Pathway Analysis;Pathway interactions;Patient-Focused Outcomes;Patients;physically handicapped;Physiology;Population;prevent;Process;professor;Proteins;Proteomics;Quality of life;recruit;regenerative;regenerative therapy;Research;Research Activity;research and development;Research Personnel;resilience;response;Science;Signal Pathway;skill acquisition;skills;Source;statistics;Stress;Sweden;Synovial Cell;Synovial Membrane;T-Lymphocyte;Testing;Therapeutic;therapeutic miRNA;therapy development;Time;Tissues;Training;Training Activity;Translational Research;Universities;Virginia;Work

PROJECT_TITLE: Novel mechanisms of microRNA-mediated anabolic effects in age-related osteoarthritis

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PI_NAMEs: BARGER, STEVEN W (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease risk;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-4;Astrocytes;Blood Circulation;Brain;brain tissue;cell type;Chemicals;Defect;Desire for food;Deterioration;DNA;Drops;drug discovery;Elements;Event;Exhibits;Gene Expression Regulation;Gene Modified;Genes;genetic variant;Glucose;glucose transport;Glucose Transporter;Human;Hyperglycemia;Impaired cognition;Inflammation;innovation;Insulin Resistance;Memory;mouse model;Mus;Neurologic;Neurons;novel;Obesity;Pancreas;Pathogenesis;Performance;Peripheral;pharmacologic;Physical activity;Play;Psyche structure;Regulatory Element;Resources;Role;spatial memory;Testing;Therapeutic Agents;Therapeutic Intervention

PROJECT_TITLE: Role of glucose transport in Alzheimer's disease pathogenesis


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

PHR: Project Narrative Periodontitis (inflammatory gum disease) is strongly associated with the microbially derived molecule hydrogen sulfide. This project will define how sulfide directly contributes to two major aspects of periodontal disease: the outgrowth of oral pathogens and the development of oral immuno-pathology.

PI_NAMEs: STACY, APOLLO  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Abscess;Actinobacillus actinomycetemcomitans;Adult;Aerobic;Aerobic Bacteria;Affect;alveolar bone;Alveolar Bone Loss;Anaerobic Bacteria;Antibodies;antimicrobial;bacterial genetics;Biological Assay;Bismuth;bone loss;career;career development;Cell Respiration;co-infection;Communities;Complement;Core Facility;Cysteine;cytokine;Data;Detection;Development;Development Plans;Disease;dysbiosis;Educational workshop;Environment;Etiology;fitness;Flow Cytometry;Formulation;Future;Gases;Genetic;global health;Goals;Grant;Growth;host microbiota;Human;human disease;Hydrogen Sulfide;Immune response;Immune system;Immunity;Immunologics;Immunology;immunopathology;In Vitro;in vivo;Individual;Inflammatory;Innovative Therapy;insight;Interleukin-6;Interleukins;Intramural Research Program;Knowledge;Laboratories;Ligature;Link;Literature;Mediating;Mentors;microbial;microbiome;Modeling;mouse model;Mus;mutant;National Institute of Dental and Craniofacial Research;neutrophil;novel;Oral;oral immunology;oral microbial community;Oral Microbiology;oral pathogen;Oxidants;pathogen;Pathology;Periodontal Diseases;Periodontitis;Persons;Pharmaceutical Preparations;Positioning Attribute;Production;Productivity;Proliferating;Research;Research Personnel;Research Project Grants;Resistance;Resources;Respiration;response;Risk;Role;skills;Sulfides;Supervision;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Thigh structure;Tissues;Tooth Loss;Tooth structure;Training;translational therapeutics;United States National Institutes of Health;Writing

PROJECT_TITLE: Role of sulfide in oral microbiota-host interactions that promote periodontitis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric;Stimulant Use and Misuse

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The goal of this proposal is to develop brain imaging tools to measure the effects of methylphenidate in children and adolescents with ADHD. Specifically, we will correlate brain activity during cognitive tasks and brain chemistry with cognitive performance. These measures could then be used to develop novel drugs to treat ADHD in children and adolescents.

PI_NAMEs: BIGOS, KRISTIN L (contact)

PROGRAM_OFFICER_NAME: GRABB, MARGARET CHRISTINE

PROJECT_TERMS: Acute;Adolescent;Adult;Age;Anterior;Attention;Attention deficit hyperactivity disorder;Biological Markers;Brain;Brain Chemistry;Brain imaging;Brain region;Central Nervous System;Central Nervous System Diseases;Chemicals;Child;Childhood;cingulate cortex;Cognition;Cognitive;Cognitive deficits;cognitive performance;cognitive task;Communities;Data;Development;Disease;Dopamine;Dose;Double-Blind Method;drug development;Functional disorder;Functional Magnetic Resonance Imaging;Future;gamma-Aminobutyric Acid;Glutamates;Goals;High Prevalence;Image;Imaging Device;Imaging Techniques;improved;insight;interest;Light;Link;magnetic resonance imaging biomarker;Magnetic Resonance Spectroscopy;Measurable;Measures;multimodality;N-acetylaspartylglutamate;neural;neural correlate;neural network;neural patterning;Neurobehavioral Manifestations;neuroimaging;neuroimaging marker;Norepinephrine;novel;novel therapeutics;Oral;Outcome;Pathway interactions;Patients;Pattern;pediatric patients;Pharmaceutical Preparations;Pharmacodynamics;Pharmacological Treatment;Placebos;Plasma;Population;Prefrontal Cortex;Public Health;Reproducibility;Research;response;Ritalin;Short-Term Memory;side effect;Stimulant;Symptoms;Testing;treatment response;treatment trial;United States National Institutes of Health

PROJECT_TITLE: Multimodal brain imaging of the neural effects of methylphenidate in patients with ADHD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative The third Gordon Research Conference (GRC) on Neurobiology of Drug Addiction will be held in August 2024 in Maine, USA. About 150-200 diverse participants from around the world will attend this five-day meeting to discuss addiction research and treatment. The research presented at this GRC will highlight cutting-edge basic and clinical addiction studies on neurobiological mechanisms of compulsive drug use and relapse.

PI_NAMEs: PICCIOTTO, MARINA R (contact)

PROGRAM_OFFICER_NAME: MCCLURE-BEGLEY, TRISTAN DAVID

PROJECT_TERMS: addiction;Address;Alcohols;Animals;Area;Automobile Driving;Biosensor;Brain;brain circuitry;career;career development;Clinical;Clinical Research;clinical translation;Collaborations;Communication;Compensation;Country;Development;Drug Addiction;drug relapse;Drug usage;Ethnic Origin;Event;Formulation;Fostering;Foundations;frontier;Future;gender diversity;Goals;Growth;Human;in vivo imaging;Interdisciplinary Study;International;Laboratories;lectures;Maine;meetings;member;Molecular;multidisciplinary;Nervous System;neurobiological mechanism;Neurobiology;neuromechanism;Neurosciences;Neurosciences Research;next generation;novel;novel strategies;optogenetics;Participant;Pharmaceutical Preparations;Postdoctoral Fellow;posters;prevent;Race;Request for Applications;Research;research and development;Research Personnel;Research Technics;Scientific Advances and Accomplishments;Scientist;Shapes;social;student participation;Students;symposium;Techniques;Technology;theories;Therapeutic;Time;Translational Research;Travel;Withdrawal

PROJECT_TITLE: 2024 Neurobiology of Drug Addiction Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 GXM-T (O1)]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Perinatal medicine and biology has major public health consequences with the growing recognition that perinatal life is a major determinant of disease in adult life. The PRS Young Investigator Training Workshop enhances and accelerates the development of young investigators in the field of perinatal medicine and biology through grantsmanship and communication skills. This means we are helping ensure a future pool of outstanding physician-scientists and basic-scientists to improve health and disease during the perinatal period, consistent with the mission of NIH.

PI_NAMEs: ALBERTINE, KURT H (contact);EDLOW, ANDREA GOLDBERG;JOSS-MOORE, LISA ANNE

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Acceleration;Active Learning;Adult;Applications Grants;Award;Basic Science;Biology;Clinical;Communication;Critiques;design;Development;Discipline of obstetrics;Disease;diversity and inclusion;educational atmosphere;Educational process of instructing;Educational workshop;Elements;Ensure;Environment;expectation;Extramural Activities;faculty mentor;Feedback;Fostering;Foundations;Funding;Funding Agency;Future;Goals;Grant;Graph;Health;Immersion;improved;innovation;Instruction;interest;investigator training;Learning;Life;meetings;Mentors;Mission;National Institute of Child Health and Human Development;next generation;Oral;oral communication;Outcome;Outcome Measure;Participant;Pediatrics;Perinatal;perinatal medicine;perinatal period;Physicians;Process;programs;Public Health;Records;recruit;Request for Proposals;Research;Research Personnel;Scientist;Series;skills;Slide;Societies;Study Section;success;Time;Training;Underrepresented Minority;United States National Institutes of Health;Woman;Writing

PROJECT_TITLE: PRS Young Investigators Grants Workshop

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: Cold Spring Harbor Laboratory Lecture Course NEUROSCIENCE OF ADDICTION (2024-2027) Narrative  The societal consequences of drug abuse and drug addiction are enormous. Over the past forty years, research on the mechanisms of action of addictive drugs have focused on pharmacology and behavioral pharmacology studies. With the rapid growth in molecular and systems neuroscience in the last two decades and the completion of the human genome more than a decade ago, integration between behavioral or physiological responses and molecular, genetic and cellular responses to addictive drugs is increasingly possible, opening new avenues for the understanding of drug use and drug abuse. Together with the development of increasingly sophisticated preclinical models of the disorder in rodents, amalgamation of these disciplines into contemporary research into the biobehavioral basis of the vulnerability to develop drug addiction requires a profound appreciation for the strengths and weaknesses of each approach. The theme of the proposed lecture course is to provide young and emerging scientists with the most up-to-date and exhaustive information on how tissues, cells and genes respond to drugs of abuse differently between individuals across species. This week-long residential course is targeted to both new and experienced investigators, and combines formal presentations and informal discussions to convey the merits and excitement of behavioral, cellular and molecular approaches to drug addiction research. The course will stress the significance of this approach not only to the most costly neuropsychiatric disorder, addiction, but its applicability to learning, memory, and other disciplines of neuroscience. Research on the psychological, neural, cellular and molecular and cellular changes that occur in response to drugs is critical for clarifying whether adaptive processes are diverse for each stage of addiction and for each drug of abuse. Ultimately, new treatments for these disorders are likely to emerge from a better understanding of the processes that go awry in vulnerable individuals during the transition from controlled to compulsive drug seeking and taking.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Acute;addiction;Archives;Area;Asia;Asian;Attention;Awareness;Behavioral;behavioral pharmacology;biobehavior;Biological Response Modifier Therapy;Brain;Brain imaging;career development;Cells;Cellular biology;Clinical;Collaborations;cost;craving;design;Development;Discipline;Disease;disease model;Drug abuse;Drug Addiction;drug development;drug discovery;drug of abuse;Drug Targeting;Drug usage;Effectiveness;Electronic Mail;Emerging Technologies;Ensure;Environment Design;Equilibrium;Ethics;Europe;European;Evaluation;experience;Exposure to;Faculty;Fostering;Foundations;Future;Genes;Genetic;Genomics;Genotype;Human Genome;Individual;instructor;interdisciplinary approach;interest;International;Japan;Laboratories;Lead;Learning;lecturer;lectures;long term memory;Measures;Memory;Mentors;mindfulness;Minority;Modeling;Molecular;Molecular Biology;Molecular Target;neural;neural circuit;neuroadaptation;Neurobiology;neuroinformatics;neuropsychiatric disorder;Neurosciences;new technology;New York;north shore long island;novel;Online Systems;Participant;Perception;Pharmaceutical Preparations;Pharmacology;Pharmacology Study;Physiological;Portugal;pre-clinical;Pre-Clinical Model;Predisposition;present value;Process;programs;Proteomics;psychologic;Public Policy;Publications;rapid growth;receptor;Relapse;Research;Research Personnel;response;Rodent;Route;satisfaction;Scientist;Site;Stress;Structure;Students;Suggestion;Surveys;symposium;System;Techniques;Tissues;Training;Universities;Vulnerable Populations;Walking;Woman

PROJECT_TITLE: CSHL Neuroscience of Addiction Course (2024-2027)


NIH_SPENDING_CATS: Bioengineering

PHR: Narrative The 2024 Gordon Research Symposium (GRS) and Gordon Research Conference (GRC) on Colloidal, Macromolecules and Polyelectrolyte Solutions aims to explore the innovation of these materials and techniques for their characterization, focusing on engineering diverse soft matter systems. These conferences will bring together scientists with diverse backgrounds and expertise with a strong commitment for supporting students, postdocs and early career scientists. The GRS and GRC will also enhance diversity, equity and inclusion by ensuring representation in our invited speakers and discussion leaders, increasing participation by advertising to professional societies and minorities serving institutions and a strong commitment to creating safe and welcoming environments.

PI_NAMEs: SCHULTZ, KELLY M (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: 3D Print;Address;Advertising;Area;Biocompatible Materials;Biogenesis;Biological;biological development;Biomimetic Materials;career;Collaborations;Colloids;Communities;delivery vehicle;design;Detection;Development;Disease;Disease Progression;Engineering;Ensure;Environment;Equilibrium;equity, diversity, and inclusion;experimental study;Funding;Goals;graduate student;Health;Home;innovation;insight;interest;Knowledge;macromolecule;manufacture;Methods;Mind;Minority-Serving Institution;Mission;Motivation;National Institute of Biomedical Imaging and Bioengineering;Nature;new technology;novel;Postdoctoral Fellow;Professional Organizations;programs;Property;Research;Running;Scientist;Structure;Students;supportive environment;symposium;synergism;System;Systems Development;Techniques;Time;tissue regeneration;United States National Institutes of Health;Work

PROJECT_TITLE: 2024 Colloidal, Macromolecular and Polyelectrolyte Solutions Gordon Research Conference and Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (O1)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Physical Injury - Accidents and Adverse Effects;Prevention;Violence Research

ORG_CITY: IOWA CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative This project, ICREATE (Injury Capacity in Research in EAsTern Europe), expands successful capacity building in injury and violence research and education in Armenia, Georgia, and Moldova. Training is led by a strong collaborative team at the University of Iowa in the US and the University of Babes-Bolyai in Romania. This partnership has implemented injury core curricula in public health degree programs and established research in our focus areas of road traffic injury, violence against women and children, and will improve acute injury treatment, and we expand to examine alcohol as a risk for injury and implementation science. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: DULF, DIANA ;HAMANN, CARA  (contact);PEEK-ASA, CORINNE

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Accident and Emergency department;Active Learning;acute care;Agreement;Alcohol consumption;Area;Armenia;Brain Injuries;Country;Course Content;Data;Databases;Degree program;Doctor of Philosophy;doctoral student;Eastern Europe;Economics;Education;Educational Curriculum;Educational process of instructing;Europe;European Union;Faculty;Funding;Grant;Hospitals;implementation science;Injury;injury burden;injury prevention;innovation;Institution;Interpersonal Violence;Iowa;Leadership;low and middle-income countries;Mentors;Methodology;Middle East;Moldova;Names;Paper;Politics;Positioning Attribute;Prevention program;programs;prospective;Publications;Publishing;Registries;Research;Research Personnel;Russia;skills;Students;symposium;Time;Training;Translating;Trauma;Traumatic injury;treatment program;undergraduate student;United States National Institutes of Health;Universities;Violence;violence prevention

PROJECT_TITLE: ICREATE: Increasing Capacity for Injury Research in Eastern Europe


NIH_SPENDING_CATS: Cancer;Dissemination and Implementation Research;Lung;Lung Cancer;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: MADISON

ORG_NAME: SOCIETY FOR RESEARCH ON NICOTINE/TOBACCO

ORG_STATE: WI

PHR: PROJECT NARRATIVE The SRNT Annual Meeting has is a unique venue for presentation of novel findings from global tobacco control research projects and for networking among scientists in the field. This conference grant aims to organize a pre-conference workshop and presidential symposium to promote bidirectional learning in global tobacco control and implementation science; increase abstract submissions in global tobacco control science; offer travel scholarships for LMIC-based researchers; and support post-conference article submissions that focus on implementation science in global tobacco control.

PI_NAMEs: COHEN, JOANNA E;SALLOUM, RAMZI GEORGE (contact);SHELLEY, DONNA R;THRASHER, JAMES

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: Achievement;Africa;Area;Asia;Award;Basic Science;career;career networking;Central Asia;Clinical Research;Collaborations;Country;Dedications;Development;Educational workshop;Employee;Ensure;Epidemiology;Evidence based practice;experience;Fees;Fostering;Funding Agency;Generations;Geographic Locations;global health;Government;Grant;health equity;implementation research;implementation science;Income;International;Intervention;Journals;Knowledge;Latin America;Learning;Location;low and middle-income countries;meetings;member;Mission;Nicotine;novel;Participant;Policies;programs;Public Health;public policy on tobacco;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Scholarship;Science;Scientific Societies;Scientist;Scotland;Societies;support network;symposium;Tobacco;tobacco control;Tobacco Control Research;tobacco products;tobacco user;Travel

PROJECT_TITLE: SRNT 2024 Annual Meeting Global Support

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (O1)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Genetics;Mental Health;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative  The proposed project will investigate the transcriptomic contributions of human and non-human primate brain development. While transcriptomic variability is well understood in early prenatal stages, especially for animal models, it is still unclear how gene expression varies across later stages in human brain development. Findings from this work will advance our knowledge of human-related genes that may play a key role in typical development and identify key windows for future clinical and mental health applications.

PI_NAMEs: KING, LEANA  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Adolescence;Adult;Anatomy;Animal Model;Atlases;Autopsy;axon guidance;Behavior;Brain;career;cell type;Cerebral cortex;Childhood;Clinical;Cognition;Committee Members;Complement;Complex;Data;Development;differential expression;Ensure;Evolution;Fellowship;Future;gene conservation;Gene Expression;Gene Expression Profile;gene expression variation;Genes;Genetic;Genetic Code;gliogenesis;health application;Heterogeneity;Human;Human Development;in silico;In Situ;In Situ Hybridization;insight;Knowledge;Life;life span;Macaca;Mental disorders;Mental Health;Methodology;Methods;Modality;Molecular;multimodality;myelination;Neocortex;neural;Neuroanatomy;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;neurogenetics;neuroimaging;Neurologic;Neurosciences;nonhuman primate;novel;Outcome Study;Pathway Analysis;Pattern;Play;Postdoctoral Fellow;prenatal;Process;Property;Research;Research Personnel;Resources;Specificity;Technology;Therapeutic Intervention;Thick;Tissue-Specific Gene Expression;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Translating;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Transcriptomic contributions to the development and evolution of the human cerebral cortex

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Emerging evidence from recent genome-wide studies has revealed that promoters across eukaryotes are commonly paired to drive bidirectional transcription. Work in yeast suggests bidirectional transcription could be the naïve or innate state of transcription initiation with directionality evolving due to the action of diverse pathways. Building on our initial success in developing a highly efficient in vitro reconstitution system of transcription initiation from highly purified yeast factors, we set out to further develop this system to solve the mechanism of divergent transcription through structural and biochemical dissection.

PI_NAMEs: MURAKAMI, KENJI  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: analytical ultracentrifugation;Biochemical;Complex;crosslink;Cryoelectron Microscopy;Dissection;Eukaryota;Genetic Transcription;genome-wide analysis;In Vitro;Mass Spectrum Analysis;Mediator;Molecular;Pathway interactions;Polymerase;promoter;reconstitution;RNA Polymerase II;Series;success;System;Transcription Initiation;Work;Yeasts

PROJECT_TITLE: Functional and structural studies of the transition from transcription initiation to elongation

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: ES

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: EAST LANSING

ORG_DEPT: NUTRITION

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: NARRATIVE Per- and polyfluoroalkyl substances (PFAS) comprise a class of several thousand compounds that present a major public health problem worldwide. The 4th National Conference on Per- and Polyfluoroalkyl Substances – Environmental Justice and Scientific Discovery, will be held in Ann Arbor, MI, a region affected by PFAS drinking water contamination. This meeting will uniquely convene scientists, government officials, environmental justice activists, affected community members, journalists, utility managers, and lawyers to examine the complex set of social, scientific, political, and environmental health issues associated with PFAS exposure and to cultivate cross-sector collaborations to more effectively prevent future exposure and protect human health.

PI_NAMEs: CARIGNAN, COURTNEY C (contact)

PROGRAM_OFFICER_NAME: TROTTIER, BRITTANY

PROJECT_TERMS: Administrator;Affect;archive data;Awareness;chemical property;Collaborations;Communication;Communities;Complex;consumer product;contaminated drinking water;Cosmetics;Country;data archive;drinking water;Ensure;Environment;Environmental Health;environmental justice;Exposure to;Feedback;field trip;Future;Goals;Government Agencies;Government Officials;Health;Human;Industrial Product;Industry;interest;International;Knowledge;Lawyers;legal cases;Location;marginalized community;meetings;member;Michigan;National Institute of Environmental Health Sciences;Organism;Outcome;Persons;Politics;Poly-fluoroalkyl substances;prevent;Public Health;Public Sector;remediation;Reporting;Research;Resistance;Resource Sharing;Resources;Risk;Science;Scientist;Shapes;Signal Recognition Particle;social;Stains;symposium;Testing;Universities;Update;Voice;Water;web site

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 ARL-W (13)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE The laboratory mouse is the best genetically defined experimental vertebrate model organism for humans and, with widespread use in biomedical research, continues to present a major opportunity for advancement in the understanding of the genetics, biology and interventions of human disease. While many institutions provide ample access to didactic courses, few, if any, have intensive hands-on training in the experimental use of the laboratory mouse. Therefore, we propose to provide a unique opportunity to the next generation of biomedical researchers and health care providers by adapting a highly successful and high-impact workshop that we have thus far offered at The Jackson Laboratory and taking it “on the road” to their home institutions with an explicit focus on reducing barriers to participation by diverse and disadvantaged learner groups.

PI_NAMEs: BERWIN, BRENT L (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Active Learning;Address;Animal Experimentation;Animal Model;Biology;Biomedical Research;career;career development;Cells;Certification;Clinical;Communities;cost;Development;Disadvantaged;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Equity;Ethics;Evaluation;experience;Faculty;Feedback;Genetic;Harvest;Health Personnel;Home;Human;human disease;human model;Injections;Institution;instructor;interest;International;Intervention;Laboratories;laboratory equipment;laboratory experience;Laboratory mice;Lead;Learning;Mammals;Measures;Methodology;Minority-Serving Institution;model organism;Modeling;Modernization;mouse model;Mus;next generation;Operative Surgical Procedures;Organ;Outcome;Participant;Positioning Attribute;Program Evaluation;programs;Research;research facility;Research Personnel;Resources;restraint;Scientist;Site;skill acquisition;skills;success;Surgical sutures;symposium;Techniques;The Jackson Laboratory;therapeutic development;tool;Training;Training Activity;Travel;United States National Institutes of Health;veterinary science

PROJECT_TITLE: Foundational Training in the Use of the Laboratory Mouse as a Model of Human Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZOD1 IMST-R (90)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Natural Products

PHR: Narrative Marine natural products, derived from the richest biodiversity resource of our planet, represent diverse chemical scaffolds with new pharmacology to address issues in human diseases. The 2024 Marine Natural Products Gordon Research Seminar (GRS) and Gordon Research Conference (GRC) will bring together up to 200 students, postdocs, early career and established investigators, providing a platform for discussing innovative research ideas in a highly interactive forum. The scientific program emphasizes latest advances in the field of marine natural products science, enabling technologies, novel structure scaffolds, pharmacology, and supply issues that are critical for developing new therapeutics to combat infectious diseases, cancer, and other diseases.

PI_NAMEs: LUESCH, HENDRIK  (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Academia;Address;Analytical Chemistry;analytical tool;Antibody-drug conjugates;Area;Biodiversity;Bioinformatics;bioinformatics tool;Biological;Biology;Biotechnology;career;career development;Central Nervous System Diseases;Chemicals;Collaborations;collaborative environment;combat;Communicable Diseases;computerized tools;Cryoelectron Microscopy;Databases;Development;Discipline;Disease;drug development;Ecology;educational atmosphere;empowerment;Ensure;Environment;Equilibrium;experience;Female;Fostering;frontier;Funding;Future;Gender;Genomics;Goals;Government;graduate student;Health;Hour;Human;human disease;Industry;innovation;insight;Interdisciplinary Study;International;Knowledge;Leadership;Machine Learning;Malignant Neoplasms;marine;marine natural product;marine organism;meetings;member;Methodology;Methods;Mission;Molecular;National Center for Complementary and Integrative Health;Natural Products;novel;novel therapeutics;Oral;Outcome;Participant;peer;Penetration;Personal Satisfaction;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Phenotype;Planets;Play;Postdoctoral Fellow;posters;preclinical development;Prevention;Process;Production;Productivity;programs;Research;Research Personnel;Resources;Role;Sampling;scaffold;Science;Scientist;screening;skills;small molecule;social;Structure;Students;symposium;Synthesis Chemistry;Technology;Therapeutic;tool;Training;training opportunity;Translating;translational applications;translational potential;trend;Underrepresented Populations;United States National Institutes of Health;Validation;Woman

PROJECT_TITLE: Marine Natural Products Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (01)]


ORG_CITY: CLEVELAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE This project develops computational modeling tools that can be used to predict the best treatment for heart failure due to poor systolic or diastolic function. The long-term goal is to improve care and outcomes for individuals who suffer various types of heart failure.

PI_NAMEs: CAMPBELL, KENNETH S;STELZER, JULIAN  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Acceleration;Actins;Animals;ATP phosphohydrolase;Behavior;Binding;Biological Assay;Biology;C2 Domain;Cardiac;Cardiac Myosins;Cardiovascular system;Caring;Cells;Classification;clinical translation;Collaborations;Complex;Computer Models;Contracts;Custom;Data;design;Development;Disadvantaged;Disease;Doctor of Philosophy;Echocardiography;EFRAC;Exercise;experience;experimental study;Fluorescence;Functional disorder;Gene Delivery;Generations;genetic regulatory protein;genetic variant;Goals;Heart;Heart Diseases;Heart failure;heart function;Heart Rate;hemodynamics;high throughput analysis;high throughput screening;Human;human tissue;Impairment;improved;in vivo;in vivo evaluation;Individual;innovation;Kinetics;mathematical model;Microfilaments;Modeling;Modification;Molecular;mouse model;multidisciplinary;Mus;myocardial biopsy;Myocardium;Myosin ATPase;myosin-binding protein C;N-terminal;open source;optimal treatments;Organ;Outcome;Output;Patients;Pattern;Performance;Phosphorylation;Physiologic pulse;Physiology;pre-clinical;predictive modeling;preservation;prevent;recruit;Regulation;Relaxation;Research;Research Personnel;Role;Sampling;Sarcomeres;skills;small molecule;Source Code;Specimen;Speed;Stress;Syndrome;Techniques;Testing;Time;tool;Transfection;Variant;Viral

PROJECT_TITLE: Computer modeling of myosin binding protein C and its effects on cardiac contraction

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

PHR: PROJECT NARRATIVE Thalamocortical interactions play diverse roles in sensory perception, sleep, cognition, and the initiation of complex actions. This 2024 GRS/GRC meeting will bring together an international community of scientists and physicians from diverse backgrounds and areas of expertise to discuss and debate new findings related to the thalamus and its interconnected networks in health and disease. All facets of the conference are designed to incorporate gender balance and diversity, and to engage participants at all career stages.

PI_NAMEs: PAZ, JEANNE T (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Address;Administrator;Americans with Disabilities Act;Architecture;Area;Arousal;Behavioral;Black race;Brain;Brain region;California;career;career development;Categories;Child Care;Climate;Cognition;Collaborations;Communication;Communities;community building;Complex;COVID-19;Decision Making;design;Development;Disease;Doctor of Philosophy;educational atmosphere;Ensure;Environment;Equilibrium;Evaluation;Event;Exercise;experience;Face;Faculty;Feedback;Fostering;Future;Gender;Goals;Health;Hour;Individual;insight;International;Knowledge;Laboratories;Leadership;Length;Lesbian Gay Bisexual Transgender Queer;Locales;Manufactured basketball;meetings;member;Mentors;Mentorship;Minority Groups;Molecular;Motor;Native Americans;Neurophysiology - biologic function;novel strategies;Outcome;Participant;patient engagement;Perception;Physicians;Play;Positioning Attribute;posters;programs;Research;Research Personnel;response;Role;Running;Schedule;Science;Scientist;self organization;Sensory;Site;Sleep;social;Structure;symposium;System;Thalamic structure;Therapeutic;Thinking;Time;Training;Translating;Underrepresented Populations;unpublished works;virtual;Woman;Women's Group

PROJECT_TITLE: 2024 Thalamocortical Interactions Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-P (11)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Osteoporosis;Rare Diseases

PHR: PROJECT NARRATIVE: The skeleton is an organ with numerous vital functions. The 2024 Bones and Teeth Gordon Research Conference and Seminar will discuss major new discoveries regarding the skeleton and its functions. These new and exciting discoveries may lead to novel treatments for devastating diseases including osteoporosis, bone cancer, genetic disorders of the skeleton, and skeletal problems associated with diabetes.

PI_NAMEs: O'BRIEN, CHARLES A (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Affect;Albers-Schonberg disease;Area;Biology;bone;career;career development;Cell Differentiation process;Cells;Collaborations;Communication;Development;Diabetes Mellitus;Disabled Persons;Disease;Emerging Technologies;Environment;experience;Fostering;Friends;Genetic Diseases;Goals;Investigation;Knowledge;Maintenance;Malignant Bone Neoplasm;mechanical load;meetings;Mentors;Mentorship;mineralization;Natural regeneration;novel;novel strategies;Organ;Osteoporosis;outreach;Participant;Pathologic;Pathology;Physiological;Physiology;posters;Productivity;programs;Rare Diseases;Research;Research Personnel;Research Support;Scientist;skeletal;skeletal disorder;skeletal tissue;Skeleton;Source;stem;stem cells;symposium;Technology;Tissues;Tooth structure;translational potential;Travel;Underrepresented Minority;Woman

PROJECT_TITLE: 2024 Bones and Teeth Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Obesity

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE: Metabolic dysregulation with all of its pathophysiological sequelae, including diabetes, cardiovascular disease and cancer, continues to be on the rise. We need to identify new areas that can be targeted for improvements in systemic metabolism. Over the last funding period, we have made significant progress towards defining key processes in the white adipocyte that lead to mitochondrial challenges and consequently, impaired adipose tissue dysfunction. These include challenges to the mitochondrial import machinery, loss of mitochondrial DNA and a dysregulation in iron metabolism. Here, we propose to integrate these challenges to examine how they feed into the mitochondrial Integrated Stress Response, leading to impaired downstream read-outs, such as reduced adiponectin release. This should identify new target areas for anti-diabetic and anti-cardiovascular disease intervention.

PI_NAMEs: SCHERER, PHILIPP E (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Address;Adipocytes;adipokines;adiponectin;adipose derived stem cell;Adipose tissue;Aging;Amyloid beta-Protein Precursor;Anti-diabetic Drugs;Area;biological adaptation to stress;carbohydrate metabolism;Cardiovascular Diseases;Cell Communication;Cell Physiology;cell type;Cells;Circulation;Deterioration;Diabetes Mellitus;Endoplasmic Reticulum;endoplasmic reticulum stress;energy balance;Equilibrium;Excision;exosome;experimental study;extracellular vesicles;Functional disorder;Funding;Glucose;Grant;Health;Heart;Homeostasis;Impairment;improved;in vivo;insight;Insulin Resistance;Intervention;Iron;iron metabolism;Lipids;Liver;Macrophage;Maintenance;Malignant Neoplasms;Measures;Mediating;Metabolic;Metabolism;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial Matrix;Mitochondrial Proteins;Modeling;Monitor;mouse model;novel;Obesity;obesity development;Organ;overexpression;oxidation;Pancreas;Pathway interactions;Performance;Phenotype;Physiology;Ploidies;Positioning Attribute;precursor cell;Process;Production;Protein Import;Regulation;Reporter;response;rho;Role;sensor;Signal Transduction;Site;stem cells;Stress;stressor;Structure;Submitochondrial Particles;System;Testing;Time;Tissues;Titrations;tool

PROJECT_TITLE: White Adipose Tissue Physiology, Mitochondrial Function and Adiponectin

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunization;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Metastatic HPV-associated cancers cause substantial mortality in the United States and throughout the world. This project seeks to develop a novel, personalized, molecularly targeted, gene-engineered, T-cell immunotherapy to improve treatment of advanced disease.

PI_NAMEs: CAO, JIAN ;GULLEY, JAMES L.;HINRICHS, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Adoptive Transfer;advanced disease;Antigen Presentation;Antigens;Anus;Autologous;Avidity;biomarker discovery;cancer cell;Cancer Etiology;Cancer Institute of New Jersey;Cancer Vaccines;Carcinoma;Cell Therapy;Cells;Cervix Uteri;Cessation of life;checkpoint receptors;chemotherapy;Clinical;clinical center;Clinical Trials;Collaborations;computational pipelines;Custom;Data;Detection;Disease;Disseminated Malignant Neoplasm;Dose Limiting;Drug Kinetics;effective therapy;Engineered Gene;engineered T cells;Exclusion;experience;Foundations;Frequencies;gene-targeted therapy;Genes;Geographic Locations;Goals;HPV E7;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;immune checkpoint blockade;Immunooncology;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Infiltration;Institution;Interferon Type II;Lesion;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant neoplasm of penis;Malignant neoplasm of vulva;Malignant Neoplasms;malignant oropharynx neoplasm;Malignant Vaginal Neoplasm;manufacture;manufacturing process;Mediating;Modeling;Molecular;Molecular Profiling;Molecular Target;mortality;next generation;next generation sequencing;novel;novel therapeutics;Oncogenic;Oncoproteins;Oropharyngeal;palliation;Papillomavirus Transforming Protein E6;patient screening;Patient Selection;patient subsets;Patients;Pattern;penis;phase 1 study;Phase I Clinical Trials;phase I trial;Phase II Clinical Trials;phase II trial;Proteins;receptor expression;recruit;Recurrence;Refractory;Refractory Disease;Research;Research Personnel;Resistance;resistance mechanism;response;Role;Safety;screening;Services;success;Systemic Therapy;T cell therapy;T memory cell;T-Cell Receptor;T-Cell Receptor Genes;T-Lymphocyte;Testing;therapeutic vaccine;therapy resistant;Time;Tissues;Toxic effect;Translational Research;treatment strategy;tumor;Tumor Escape;Tumor Volume;United States;United States National Institutes of Health;Vaccines;Vagina;Veins;Vulva

PROJECT_TITLE: E7 TCR-T cell therapy for HPV-associated cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-O (O1)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Disability Research;Hearing Loss;Prevention;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Narrative Approximately 15% of American adults aged 18 and over (38 million people) report some trouble hearing. Of these, about 29 million U.S. adults could benefit from using hearing aids. The 2024, 2026, and 2028 meetings of the International Hearing Aid Research Conference (IHCON) will advance knowledge and facilitate progress in research and development related to the treatment of hearing impairment with hearing aids, through the exchange of current research findings and technical advancements.

PI_NAMEs: PURIA, SUNIL  (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Academia;Adult;aged;American;Area;Award;Black Populations;Communities;design;Devices;Diagnosis;Disabled Persons;Discipline;equity, diversity, and inclusion;Faculty;falls;Fostering;Funding;Goals;graduate student;Grant;Hearing;Hearing Aids;hearing impairment;Hispanic Populations;Industry;Interdisciplinary Study;interest;International;Knowledge;Leadership;Letters;medical specialties;meetings;member;Mentors;Modeling;Native Americans;Oral;outreach;Participant;Patient Recruitments;Persons;Postdoctoral Fellow;posters;Principal Investigator;Printing;Process;programs;Reporting;Research;research and development;Research Personnel;Scholarship;Scientist;student mentoring;Students;symposium;Time;Training;Underrepresented Populations;United States National Institutes of Health;Voting;web page;Woman;Work

PROJECT_TITLE: International Hearing Aid Conference (IHCON) 2024

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


PHR: Narrative Sensory and signal transduction processes are essential for bacterial pathogens to produce virulence factors, to resist antimicrobials, to invade host tissues, and to evade the immune system. The 2024 STIM GRC will gather researchers from diverse fields to understand how bacteria sense and respond to their environment at levels that range from molecular mechanisms to interactions with the host on organismal level. The meeting will provide a powerful collaborative platform to address these questions from different perspectives, which will inform new strategies to develop antimicrobials and to combat infectious diseases.

PI_NAMEs: SCHARF, BIRGIT E (contact)

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TERMS: Address;Allergic Disease;antimicrobial;Antimicrobial Resistance;Applied Research;Area;Bacteria;bacterial genetics;Bacteriophages;Basic Science;behavior prediction;Biochemistry;biological adaptation to stress;Biology;Biomedical Engineering;Biophysics;career;Cell Physiology;Cells;Cellular biology;Chemicals;Collaborations;combat;Communicable Diseases;Communication;Communities;Cryo-electron tomography;Data;defense response;design;Development;Disease;Eating;educational atmosphere;Engineering;Environment;Event;Evolution;experimental study;fighting;Fostering;Goals;graduate student;host colonization;host-microbe interactions;Image;Immune Evasion;Immune system;Immune System Diseases;Industrialization;innovation;interdisciplinary collaboration;interest;Invaded;Knowledge;macromolecular assembly;Macromolecular Complexes;mechanotransduction;Mediating;meetings;Metabolic;Methods;microbial;Microbial Biofilms;microbial community;Microbiology;microbiome;Microfluidics;microorganism;Mission;Modeling;Molecular;Molecular Genetics;molecular imaging;Motility;National Institute of Allergy and Infectious Disease;optogenetics;Participant;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Persons;Postdoctoral Fellow;posters;prevent;Process;programs;Property;receptor;Regulation;Research;Research Personnel;Resolution;Role;Science;Scientist;Second Messenger Systems;Sensory;sensory integration;sensory mechanism;Signal Transduction;single molecule;skills;Specialist;Structure;success;supportive environment;symposium;System;Systems Biology;Techniques;Time;Tissues;Training;ultra high resolution;Underrepresented Populations;United States National Institutes of Health;Viral;Virulence;Virulence Factors;Work

PROJECT_TITLE: 2024 Sensory Transduction in Microorganisms Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 BJM-D (S2)]


PHR: Narrative The Gordon Research Conference on New Antibacterial Discovery and Development gathers a community of researchers dedicated to identifying and overcoming challenges in discovering and developing new antibacterial drugs to combat the increasing threat of multi-drug resistant bacterial infections. Distinct from other conferences, the GRC on NADD emphasizes collaboration among experts from academia, industry, and government, enabling diverse perspectives to be shared and addressing unique challenges at each stage of the discovery and development process, ultimately aiming to find innovative solutions and maintain a strong pipeline of essential antibacterial therapies for future generations.

PI_NAMEs: SMITH, PETER  (contact)

PROGRAM_OFFICER_NAME: MULACH, BARBARA L

PROJECT_TERMS: Academia;Address;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Area;Bacteria;Bacterial Drug Resistance;Bacterial Infections;Basic Science;Biotechnology;career;Cell Membrane Permeability;Cells;Chemicals;Chemistry;Clinic;Clinical;clinical development;Clinical Pathways;clinical practice;Clinical Trials;Collaborations;collaborative environment;combat;Combined Modality Therapy;commercialization;Communicable Diseases;Communication;Communities;COVID-19;COVID-19 pandemic;Critical Thinking;Dedications;design;Development;drug development;Drug resistance;drug resistant bacteria;Economics;Ecosystem;Ensure;Environment;Failure;fighting;Fostering;Foundations;Future;Future Generations;future pandemic;global health;Goals;Government;improved;Industry;Infection;inhibitor;innovation;insight;interest;Lead;lead optimization;Learning;Medicine;meetings;Membrane;membrane biogenesis;Multi-Drug Resistance;multidisciplinary;National Institute of Allergy and Infectious Disease;Natural product discovery;new technology;new therapeutic target;next generation;novel;novel strategies;novel therapeutics;novel vaccines;pathogen;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Positioning Attribute;Predisposition;Prevalence;prevent;Process;Public Health;Research;Research Personnel;Resistance;resistance mechanism;Risk Taking;Scientist;Societies;success;symposium;Technology;Virulence;Virus Diseases

PROJECT_TITLE: 2024 New Antibacterial Discovery and Development Gordon Research Conference and Gordon Research Seminar