ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Childhood Obesity;Congenital Structural Anomalies;Diabetes;Gene Therapy;Genetics;Obesity;Orphan Drug;Pediatric;Rare Diseases

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Prader-Willi syndrome (PWS) is associated with many clinical and behavioral problems, including severe obesity, however treatment options are limited to managing symptoms, so new approaches are needed since the disease basis is unknown and multiple genes cause PWS. This project will assess an innovative gene therapy approach with a single viral vector carrying multiple PWS genes, testing therapeutic rescue of PWS cell and animal models. Similar miniaturization of genetic components within a single viral gene therapy vector provides a unique capacity that broadens the impact of this novel approach.

PI_NAMEs: NICHOLLS, ROBERT D (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: adeno-associated viral vector;Affect;Animal Model;Architecture;Behavior;Behavior Therapy;Behavioral;Beta Cell;Biochemical;Biological Assay;Biological Models;Blood Glucose;Cell Line;Cell model;Cells;cellular transduction;Cistrons;Clinical;clinical diagnosis;clinical phenotype;Code;Cognitive;Complex;Data;Defect;Dependovirus;design;Development;digital;Disease;drug testing;Endocrine;endocrine pancreas development;Endoplasmic Reticulum;epigenetic therapy;Etiology;expression vector;Failure to Thrive;Family suidae;fetal;Foundations;gene product;gene therapy;Gene Transduction Agent;Genes;Genetic;genetic element;genome editing;Glucagon;GRP78 gene;Hormones;Human;Hyperphagia;Hypoglycemia;Immunohistochemistry;imprint;improved outcome;in utero;In Vitro;in vivo;Individual;Infection;Injections;innovation;Insulin;insulin secretion;insulinoma;Introns;Inverted Terminal Repeat;islet;Islets of Langerhans;Lead;loss of function;Measures;Messenger RNA;Miniaturization;miniaturize;Modeling;Molecular Chaperones;Molecular Diagnosis;Morbid Obesity;Morbidity - disease rate;mouse model;Mus;Muscle hypotonia;Neonatal;novel;novel strategies;novel therapeutics;peptide hormone;Pharmaceutical Preparations;Phenotype;Play;postnatal;Prader-Willi Syndrome;Preclinical Testing;Problem behavior;Production;promoter;protein expression;Protein Secretion;Proteins;Regulation;Regulatory Element;RNA;Rodent;Role;Series;Serotyping;Small Nucleolar RNA;SNRPN;Somatotropin;Specificity;Structure;symptom management;System;Testing;Therapeutic;therapeutic evaluation;therapy outcome;Transfection;Translations;vector;Viral Genes;Viral Genome;Viral Packaging;Viral Vector;Western Blotting

PROJECT_TITLE: Prader-Willi syndrome (PWS) gene-domain and AAV miniaturization for gene therapy

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: BIRMINGHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE: Mutations in genes affecting ciliary proteins, such as PKD2 or IFT88, cause cysts to form in the kidney, the severity of which is greatly exacerbated following renal injury. These data lead to the hypotheses that cilia function to regulate signaling pathways involved in renal repair, that these pathways become dysregulated when cilia function is perturbed, and that this leads to cyst development. The goals of this proposal are to determine whether cilia dysfunction or loss alters the kidney's susceptibility to injury, whether injured epithelium are direct contributors to cysts, and to identify the cilia and PKD2 dependent signaling networks that become dysregulated by cilia loss/dysfunction that cause kidney tubule maladaptive repair following injury and then cyst expansion.

PI_NAMEs: YODER, BRADLEY K. (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acceleration;Adult;Affect;aged;Alleles;Area;Automobile Driving;cell injury;Cells;Cilia;ciliopathy;Cisplatin;Clinical;conditional mutant;Cyst;Cystic kidney;Cystic Kidney Diseases;Data;Defect;Development;Disease Progression;Epithelial Cells;epithelial injury;Epithelium;Erinaceidae;experience;Functional disorder;Gene Expression Profile;Genes;Genetic Epistasis;Genetic Transcription;Goals;Immune;Inflammatory Response;Injury;injury and repair;Injury to Kidney;Ischemia;Kidney;Lead;Location;Mediating;Molecular;Mus;mutant;Mutant Strains Mice;Mutation;Nature;Nephrons;novel;novel strategies;Pathogenesis;Pathology;Pathway interactions;Phenotype;PKD2 protein;Predisposition;Process;protein function;Proteins;renal epithelium;Renal function;Renal tubule structure;repaired;Reperfusion Therapy;Repression;Resolution;response;response to injury;Sensory;Series;Severities;Signal Pathway;Signal Transduction;smoothened signaling pathway;Testing;tissue repair;Tissues;treatment strategy

PROJECT_TITLE: Injury Response Mediated Pathogenesis in Renal Ciliopathies

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: PROJECT NARRATIVE INIA-N investigators have shown that brain immune-related pathways are involved in excessive ethanol consumption and that pharmacological intervention with anti-inflammatory drugs reduces drinking. This project will examine the cellular and synaptic mechanisms of alcohol-induced immune responses in the brain that are hypothesized to contribute to excessive drinking. Therefore, the present studies have the potential to identify new therapeutic targets to reduce excessive drinking.

PI_NAMEs: ROBERTO, MARISA  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: addiction;alcohol behavior;Alcohol consumption;alcohol effect;alcohol preferring rats;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholism;Alcohols;Amygdaloid structure;analog;Animals;Anti-Inflammatory Agents;anxiety-like behavior;Area;Astrocytes;Automobile Driving;Basic Science;behavior measurement;Behavioral;behavioral phenotyping;behavioral study;Biochemical;Biological Assay;Brain;Brain region;Cell Nucleus;cell type;Cells;Chronic;Collaborations;Coping Behavior;cytokine;Data;Dedications;Dependence;design;Development;drinking;drug candidate;Electrophysiology (science);Ethanol;Ethanol dependence;excessive anxiety;Female;gamma-Aminobutyric Acid;Genes;genetic manipulation;Genomics;glutamatergic signaling;Glutamates;Grant;Heavy Drinking;Human;Human Resources;IL-6 inhibitor;IL6ST gene;Immune;Immune response;Immune Targeting;Immunohistochemistry;Impairment;In Vitro;Inflammation;Inflammatory;Interdisciplinary Study;Interleukin 6 Receptor;Interleukin Activation;Interleukin-1 beta;Interleukin-10;Interleukin-6;Interneurons;Intervention;Knockout Mice;Macaca mulatta;male;Medial;Mediating;Mediator;member;Microglia;Molecular;mRNA Expression;Mus;Mutant Strains Mice;negative affect;negative emotional state;neuroadaptation;Neuroglia;Neuroimmune;Neuroimmune system;Neurons;Neurosciences;new therapeutic target;overexpression;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Physiological;Play;Prefrontal Cortex;Property;Publications;Research Personnel;Research Project Grants;response;RiboTag;RNA;Rodent;Role;sex;Signal Pathway;Signal Transduction;STAT3 gene;Stress and Coping;Synapses;Synaptic Transmission;System;Testing;therapeutic target;TLR4 gene;tocilizumab;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Mice;Transgenic Organisms;Translating;translational potential;transmission process;vector induced;Viral Vector;Western Blotting;Withdrawal

PROJECT_TITLE: 9/10 Electrophysiology of Alcohol in Extended Amygdala


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE: THE UNC-CHAPEL HILL SUPERFUND RESEARCH PROGRAM North Carolina (NC) communities are impacted by inorganic arsenic (iAs) contamination of soil and water resulting from naturally occurring and industry-derived sources. With relevance to the SRP, ATSDR and USEPA, the theme of the UNC-SRP is Identifying novel methods to reduce iAs exposure and elucidating mechanisms underlying iAs-induced metabolic dysfunction with a vision for disease prevention. With relevance to the communities in NC and the US, the UNC-SRP aims to discover biological mechanisms and susceptibility factors underlying iAs-associated metabolic dysfunction/diabetes, develop novel methods and technologies to predict iAs contamination and reduce iAs exposure, and translate the science of the UNC-SRP to key stakeholders in NC and the larger SRP program, and engage vulnerable communities. !

PI_NAMEs: FRY, REBECCA  (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: Address;Amendment;Arsenic;Authorization documentation;Biological;Businesses;Chemicals;Chemistry;coal ash;Collaborations;Communication;Communities;community engagement;Data Analyses;data integration;data management;Development;Diabetes Mellitus;diabetes risk;Disease;disorder prevention;disorder risk;drinking;Ensure;environmental justice;Environmental Science;Excision;experience;Exposure to;Foundations;Future;Genotype;gut microbiome;Human;In Vitro;in vivo Model;Individual;Industrialization;Industry;innovation;Institution;interdisciplinary approach;Intervention;Knowledge;Link;Metabolic Diseases;Metabolic dysfunction;Methods;Methyltransferase;MicroRNAs;Mission;next generation;North Carolina;novel;novel strategies;Pollution;Population;Predisposition;Prevalence;prevent;Prevention;Privatization;programs;Public Health;Regulation;Research;Research Personnel;Research Project Grants;Research Technics;Risk;Rivers;rural area;Sampling;Science;Scientist;Signal Recognition Particle;Site;Soil;Source;Southeastern United States;Superfund;superfund site;Techniques;Technology;Training;transcription factor;Translating;Translational Research;United States;Universities;Vision;vulnerable community;Water;Wood material;Work

PROJECT_TITLE: The UNC Chapel Hill Superfund Research Program (UNC-SRP)


NIH_SPENDING_CATS: Prevention

PHR: NARRATIVE: ADMINISTRATIVE CORE The theme of the UNC-SRP is “Identifying novel methods to reduce iAs exposure and elucidating mechanisms underlying iAs-induced metabolic dysfunction with a vision for disease prevention.” With relevance to the communities in NC and the US, the UNC-SRP, driven by the Administrative Core, aims to discover biological mechanisms and susceptibility factors underlying iAs-associated metabolic dysfunction/diabetes, develop novel methods and technologies to predict iAs contamination and reduce iAs exposure; and translate the science of the UNC-SRP to key stakeholders in NC and the larger SRP program, and engage vulnerable communities. !

PROJECT_TERMS: Advisory Committees;Area;Biological;Biomedical Research;Budgets;Businesses;career development;Cell Culture Techniques;Chemistry;Communication;Communities;community engagement;community partners;Data;Data Analyses;data management;Diabetes Mellitus;Diabetes prevention;disorder prevention;drinking;Ensure;Environment;Environmental Engineering technology;Environmental Health;Environmental Science;Excision;experience;Feedback;Fostering;Foundations;Goals;graduate student;Health;Health Professional;Human;Human Resources;In Vitro;in vitro Model;in vivo Model;innovation;Institution;Interdisciplinary Study;Leadership;meetings;Mentors;Metabolic Diseases;Metabolic dysfunction;Methods;Mission;Monitor;mouse model;National Institute of Environmental Health Sciences;North Carolina;novel;Performance;Population;Postdoctoral Fellow;Predisposition;Privatization;Program Research Project Grants;programs;Progress Reports;Public Health;Recording of previous events;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Rivers;Role;Sampling;Science;Signal Recognition Particle;Strategic Planning;success;Superfund;superfund site;Techniques;Technology;Training;training opportunity;Translating;translational approach;translational engagement;Translational Research;Universities;Vision;vulnerable community;Vulnerable Populations;Water;Wood material;Work

PROJECT_TITLE: Core A: Administrative Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Digestive Diseases;Liver Disease;Neurodegenerative;Neurosciences;Organ Transplantation;Prevention;Transplantation

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Through re-use of an existing linked database of national transplant registry data and Medicare claims, this proposal investigates the potential benefits of mammalian target of rapamycin (mTOR) inhibitor therapy with respect to survival, morbidity and Alzheimer's disease and related dementias (AD/ADRD) in older kidney and liver transplant recipients. As a secondary objective, the significance of increasing age as a risk factor for mTOR inhibitor side effects is also studied in a large and longitudinal cohort of transplant recipients in the Veterans Health Administration. These findings will help validate the existing experimental evidence on the benefits of mTOR inhibitor therapy on aging-related diseases, support future clinical trials that aim to determine the role of mTOR inhibitors as potential disease-modifying therapies for AD/ADRD and provide key data to establish the safety and feasibility of studying mTOR inhibitors as an anti-aging therapeutic in older persons.

PI_NAMEs: BITTERMANN, THERESE  (contact)

PROGRAM_OFFICER_NAME: DUTTA, CHHANDA

PROJECT_TERMS: Adverse drug effect;Adverse effects;Age;age effect;age related;age-related disease;aged;Aging;aging related;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer's disease therapy;analog;Animal Model;Animals;anti aging;Area;bench to bedside;Benefits and Risks;Biological Models;Body System;cancer therapy;Caring;Clinical;clinical application;Clinical Data;clinical effect;clinical investigation;Clinical Trials;cohort;comorbidity;Computerized Medical Record;Consensus;Data;data registry;Data Sources;Databases;Dimensions;Disease;Dose;effective therapy;Effectiveness;Elderly;Evaluation;experience;experimental study;Feasibility Studies;FRAP1 gene;Future;General Population;Genetic;geroprotector;gerotherapeutic;hallmarks of aging;health care service;health care service utilization;Healthcare;healthcare burden;Hospitals;Human;human old age (65+);Immunosuppression;Impaired cognition;improved;Incidence;individualized medicine;inhibitor;inhibitor therapy;interest;K-Series Research Career Programs;Kidney Transplantation;Knowledge;life span;Link;liver transplantation;Longevity;Longitudinal cohort;Longitudinal Studies;Longitudinal, observational study;Malignant Neoplasms;Medicare;Medicare claim;medication safety;Modernization;Modification;Morbidity - disease rate;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Neurodegenerative Disorders;novel;older patient;Older Population;Oncology;Organ;Organ Transplantation;Outcome;Pathway interactions;Patients;Physiological;Play;Population;post-transplant;pre-clinical;Prevalence;prevent;Prevention;Process;Property;Reporting;Research;Resources;Risk;Risk Factors;Role;Safety;safety and feasibility;side effect;Signal Transduction;Sirolimus;symptomatology;Techniques;Therapy Clinical Trials;Time;transplant database;Transplant Recipients;transplant registry;Transplantation;treatment effect;tumor progression;United Network for Organ Sharing;Veterans Health Administration

PROJECT_TITLE: Impact of mammalian target of rapamycin inhibitor therapy on aging-related outcomes

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

PHR: NARRATIVE: COMMUNITY ENGAGEMENT CORE The UNC-SRP Community Engagement Core (CEC) fosters environmental health literacy and works to reduce exposures in North Carolina communities impacted by toxic metals in well water. In partnership with community- serving organizations, we increase understanding of harmful environmental exposures such as inorganic arsenic and develop locally relevant solutions to toxic metals contamination of well water. Strategies for reduction of these contaminants are of interest to the National SRP program, the USEPA and the ATSDR.

PI_NAMEs: GRAY, KATHLEEN M (contact)

PROJECT_TERMS: Address;Advocate;Amendment;Area;Arsenic;Authorization documentation;Award;Back;coal ash;Collaborations;Committee Members;Communication;Communities;community building;community engaged research;community engagement;community organizations;community partners;contaminated water;County;Creativeness;Decision Making;Development;Diabetes Mellitus;disorder prevention;drinking water;effective therapy;empowerment;Environmental Exposure;Environmental Health;environmental justice;Excision;experience;Exposure to;Filtration;Fostering;Foundations;Funding;Goals;Hazardous Substances;Health;health communication;health literacy;health science research;high risk;Industrialization;interest;Intervention;Leadership;Location;member;Metabolic dysfunction;Methods;Mission;Needs Assessment;North Carolina;novel;Persons;Policies;policy recommendation;Population;Populations at Risk;Positioning Attribute;prevent;Prevention strategy;Privatization;Problem Solving;programs;Protocols documentation;Public Health;public health relevance;Reporting;Research;Research Personnel;residence;Resources;Risk;Rivers;Sampling;Scholarship;Signal Recognition Particle;Source;Superfund;Testing;Thinking;Toxic effect;toxic metal;translational research program;Universities;Vision;Vulnerable Populations;Water;water quality;well water;Work

PROJECT_TITLE: Core B: Community Engagement Core (CEC)


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Osteoporosis

ORG_CITY: AMHERST

ORG_DEPT: DENTISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative The proposed research is relevant to public health because the understanding of the role of heparan sulfate- Sclerostin interaction in bone formation is ultimately expected to provide novel therapeutic targets in treating many diseases associated with exaggerated bone loss. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to seeking fundamental knowledge that will help to reduce illness and enhance health.

PI_NAMEs: LI, MIAOMIAO  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Address;Affect;aged;Binding;Binding Sites;Biochemical;Biological;Biological Availability;Biological Process;Biology;bone cell;Bone Diseases;bone loss;Bone Matrix;Bone Resorption;bone strength;Bone Surface;cell growth regulation;Cell Lineage;Cell surface;Complex;Data;Diffusion;Disease;Drug Targeting;experimental study;Extracellular Matrix;fracture risk;Future;Glycosaminoglycans;Health;Heparitin Sulfate;Impairment;In Vitro;in vivo;inhibitor;Knock-in Mouse;Knowledge;Mammalian Cell;Maps;Mission;Modeling;Molecular;Monoclonal Antibodies;Mouse Strains;mutant;new therapeutic target;novel;Oligosaccharides;Osteoblasts;Osteocytes;Osteogenesis;Osteoporosis;Persons;Point Mutation;Public Health;receptor;Recombinants;Research;Role;Site-Directed Mutagenesis;skeletal disorder;Stains;Surface;System;Testing;tool;tool development;translational impact;United States National Institutes of Health;WNT Signaling Pathway;Work

PROJECT_TITLE: Demystify Heparan Sulfate–Sclerostin Interactions in Bone Formation

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: PITTSBURGH

PHR: Project Narrative Oral vaccines are potentially valuable tools to prevent infections. Here we propose to build a novel transgenic mouse model that will help us understand how T cells populate the intestine after vaccination to protect against infection.

PI_NAMEs: HAND, TIMOTHY WESLEY (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;Adjuvant;Adoptive Transfer;Antigens;Attenuated;B-Lymphocytes;Bacteria;Binding;Biology;breakthrough infection;C57BL/6 Mouse;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Communication;Cells;Child;Communicable Diseases;Communities;congenic;Congenic Mice;CRISPR/Cas technology;Cytoprotection;cytotoxic;Development;Diarrhea;diarrheal disease;Dissection;engineered T cells;Enteral;enteric infection;Enteric Nervous System;enteric pathogen;enterotoxigenic Escherichia coli;Escherichia coli;Flow Cytometry;Genes;Goals;Grant;gut colonization;Image;Immune;Immune response;Immunity;Immunize;Immunoglobulin A;Infection;Infection prevention;interest;Intestines;Invaded;Listeria monocytogenes;Location;Longevity;Lymphoid Tissue;Measurement;Mediating;Memory;Memory B-Lymphocyte;memory CD4 T lymphocyte;Methods;MHC Class II Genes;Microscopy;Modeling;mortality;Motility;mouse model;mucosal site;Mucous Membrane;Mus;mutant;Nerve;novel;Oral;oral vaccine;pathogen;pathogenic bacteria;pathogenic virus;Peptides;Phenotype;Poliomyelitis;Population;Positioning Attribute;prevent;Preventive therapy;Production;Proliferating;Property;protective effect;Proteins;Research;Research Personnel;Resource-limited setting;Resources;response;restoration;Rotavirus;SARS-CoV-2 variant;Site;Small intestine mucous membrane;Small Intestines;Spleen;Surface;System;T cell response;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;tissue resident memory T cell;Tissues;tool;Toxin;transcriptomics;Transgenic Mice;Transgenic Organisms;Vaccination;Vaccinee;Vaccines;Work

PROJECT_TITLE: Investigating the tissue location and protective function of oral vaccine-specific tissue resident memory CD4 T cells

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

PHR: NARRATIVE: DATA MANAGEMENT AND ANALYSIS CORE The overarching goal of the Data Management and Analysis Core (DMAC) is to support the data management, integration, and analysis needs of the UNC-SRP researchers to reveal multi-factorial determinants of iAs-induced metabolic dysfunction/diabetes. The data management component of DMAC is housed in the Renaissance Computing Institute (RENCI) and analytical support of the DMAC is made possible through the UNC-Department of Statistics. By making data Findable, Accessible, Interoperable and Reusable (FAIR), the DMAC will maximize the impact and optimize the path to identifying high impact insights into metabolic disease/diabetes and iAs exposure and remediation evaluations. !

PI_NAMEs: AHALT, STANLEY CARLTON (contact)

PROJECT_TERMS: Address;Archives;Bioinformatics;Biostatistical Methods;cheminformatics;Communities;contaminated water;Data;Data Analyses;data integration;data management;Data Science;data sharing;Deposition;design;Development;Diabetes Mellitus;Disease;Disease susceptibility;disorder prevention;Dose;Ensure;Environmental Impact;Environmental Monitoring;Evaluation;Event;Excision;experience;Experimental Designs;Exposure to;FAIR principles;Filtration;Fostering;Generations;Genetic;Genome;Goals;gut microbiome;hazard;Health;Human Resources;insight;interoperability;Metabolic Diseases;Metabolic dysfunction;Metadata;Methods;microbiome;microbiome signature;MicroRNAs;Mission;Molecular;Mouse Strains;North Carolina;novel;Obesity;Ontology;Population;population health;Program Research Project Grants;programs;Protocols documentation;Public Health;quality assurance;Quality Control;remediation;Renaissance;Research;Research Activity;Research Design;Research Personnel;Research Support;response;Risk;Risk Assessment;Role;Sampling;Science;Scientist;Source;Statistical Methods;statistics;Sum;Superfund;System;Technology;tool;Toxicology;transcription factor;transcriptome;Translational Research;verification and validation;Vision;Work

PROJECT_TITLE: Core C: Data Management and Analysis Core (DMAC)


ADMINISTERING_IC: MH

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: CHESTNUT HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: Project Narrative. Dopamine is essential to fear learning and modulates a larger brain network, yet dopamine- focused treatments for anxiety disorders are not available. This proposal will reveal a novel A8 dopamine to ventral pallidum pathway that bidirectionally controls and normally promotes fear. The results will uncover selective inhibition of the A8 dopamine to ventral pallidum pathway as a therapeutic target to effectively treat anxiety disorders.

PI_NAMEs: MCDANNALD, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: anatomical tracing;Anatomy;Anxiety Disorders;Association Learning;Automobile Driving;Behavior;Behavioral;Bilateral;Brain;Brain region;cell type;Clinical;Corpus striatum structure;Cues;designer receptors exclusively activated by designer drugs;Diffuse;Discrimination;Dopamine;dopaminergic neuron;fluorophore;foot;Fright;Globus Pallidus;Halorhodopsins;Implant;Infusion procedures;Laboratories;Learning;Light;Lighting;Macaca;Mus;Neurons;Neurotransmitters;novel;Optics;Pathway interactions;Pharmacotherapy;Play;Procedures;Process;Prosencephalon;Rattus;Reporting;Research;Resolution;Role;Serotonergic System;Shock;Signal Transduction;Substantia nigra structure;Testing;therapeutic target;treatment of anxiety disorders;Ventral Tegmental Area

PROJECT_TITLE: An A8 dopamine-ventral pallidum threat circuit

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Microbiome;Nutrition;Prevention

PHR: NARRATIVE: CHEMISTRY AND ANALYTICAL CORE The overarching goal of Chemistry and Analytical Core (CAC) is to develop and apply ultra-sensitive and specific analytical methods to measure metals (iAs, its species and other Superfund contaminants) in environmental and biological samples and characterize toxicant-induced adverse health effects via microbiome and biomarker/metabolomics approaches. These data provide critical research support for all UNC-SRP projects and promote the integration of the UNC-SRP to better understand and protect the public from adverse health effects related to Superfund chemicals. ! !

PI_NAMEs: LU, KUN  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;absorption;acid stress;analytical method;Area;Arsenic;Bile Acids;Bioinformatics;Biological;Biological Markers;biomarker development;Chemistry;Communities;community engagement;complex data;Consultations;Data;Data Analyses;data management;Data Set;Data Storage and Retrieval;Detection;Diabetes Mellitus;Diet;disorder prevention;Education;Elements;Environmental Science;Equipment;experience;Exposure to;forging;Generations;Goals;graduate student;gut microbiome;Health;High Pressure Liquid Chromatography;host microbiome;Human Resources;Inductively Coupled Plasma Mass Spectrometry;Infrastructure;innovation;Institution;instrumentation;Knowledge;Leadership;Link;Mass Spectrum Analysis;Measurement;Measures;Metabolic;Metabolic dysfunction;metabolomics;Metagenomics;Metals;Methodology;Methods;microbiome;microbiome alteration;microbiome analysis;microbiome sequencing;MicroRNAs;Mission;next generation;novel;novel strategies;Obesity;Oxidative Stress;Play;Poison;post-doctoral training;Postdoctoral Fellow;prevent;Program Research Project Grants;programs;Protocols documentation;Public Health;public health relevance;Research;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resolution;Sampling;Scientist;Services;Shotguns;Signal Recognition Particle;Students;Superfund;superfund chemical;supportive environment;targeted biomarker;tool;toxicant;Training;transcription factor;Vision;Work

PROJECT_TITLE: Core D: Chemistry and Analytical Core (CAC)


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative The immune system senses when a cell is infected or becoming cancerous through display of fragments of microbe- or tumor-associated proteins on the surface of a cell – often the only sign of disease apparent from the outside of a cell. We have developed an improved, streamlined, novel system for identifying these markers, and will use it to identify new therapeutic targets and understand the display process. We will also explore how the immune system from cancer patients responds to the markers we identify.

PI_NAMEs: STRONG, ROLAND K (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Adoptive Immunotherapy;Alleles;Antibodies;antigen processing;Antigens;Award;Basic Science;Binding;Biochemical;Biological Assay;cancer immunotherapy;Cancer Patient;Cancerous;Cell surface;Cells;Cellular Assay;Characteristics;Clinical;clinical application;Collaborations;comparative;Complex;Coupled;Crystallography;Data;Diagnosis;Disease;engineered T cells;Epitopes;experimental study;Future;glycosylation;Histocompatibility Antigens Class I;HLA G antigen;HPV E7;HPV-High Risk;Human;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;Immune system;immunogenicity;Immunotherapy;improved;Individual;Infection;Malignant Neoplasms;Maps;mesothelin;Mesothelioma;Methodology;MHC Class I Genes;Microbe;Modality;Modeling;Molecular;Molecular Conformation;Monitor;multicatalytic endopeptidase complex;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;Oncoproteins;Papillomavirus Transforming Protein E6;pathogen;Pathway interactions;Patients;Peptide Fragments;Peptide/MHC Complex;Peptides;Pleural effusion disorder;Process;prostatic fraction Acid phosphatase isoenzyme;Proteins;Proteome;Quality Control;receptor;Renal Cell Carcinoma;Research;response;Sampling;Science;single cell sequencing;Specificity;Stains;Surface;System;T cell response;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;Time;tumor;Tumor Antigens;Tumor-Infiltrating Lymphocytes;Vaccine Therapy;Viral

PROJECT_TITLE: Deeply analyzing MHC class I-restricted peptide presentation mechanistics across alleles, pathways, and disease coupled with TCR discovery/characterization

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


PHR: NARRATIVE: RESEARCH EXPERIENCE AND TRAINING COORDINATION CORE The Research Experience and Training Coordination Core (RETCC) will provide disciplinary experiences for students in biomedical science, environmental science, and engineering disciplines. The students will gain hands-on experience with field and laboratory research, data management and analysis, community engagement, and research translation while working on problems at the interface of arsenic exposure in drinking water and human metabolic disorders. !

PI_NAMEs: GIBSON, JACQUELINE MACDONALD (contact)

PROJECT_TERMS: Address;Affect;Arsenic;Bioinformatics;Biological Sciences;Biology;Biomedical Research;Camping;career;career development;career networking;cohort;Communication;community engagement;community research;contaminated water;Data;Data Analyses;data integration;data management;Development;Development Plans;Diabetes Mellitus;diabetogen;Discipline;disorder prevention;drinking water;Educational process of instructing;Engineering;Enrollment;Ensure;Environment;Environment and Public Health;Environmental Engineering technology;Environmental Science;experience;Fertilization;Fostering;Future;Gene Expression;Genes;geochemistry;Goals;Grant;ground water;Growth and Development function;gut microbiome;Hazardous Waste Sites;Human;improved;Individual;Interdisciplinary Education;Journals;Knowledge;knowledge integration;Laboratory Research;Leadership;Maps;Metabolic Diseases;Metabolic dysfunction;Methods;MicroRNAs;North Carolina;novel;Obesity;Occupations;outreach;Phenotype;Policy Maker;Program Research Project Grants;programs;Public Health;public health relevance;Research;responsible research conduct;Risk Assessment;Role;Science;skill acquisition;skills;social;Source;Students;success;Superfund;Technology Transfer;Toxicology;Training;training opportunity;Translational Research;Translations;Vision;Work;Writing

PROJECT_TITLE: Core E: Research Experience and Training Coordination Core (RETCC)


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Diabetes;Endocrine Disruptors;Foodborne Illness;Genetics;Nutrition;Prevention

PHR: NARRATIVE: PROJECT 1 Growing evidence suggests that exposure to inorganic arsenic (iAs) increases risk of diabetes, but the underlying molecular mechanisms are poorly understood. This project will use in vivo and in vitro techniques to test the role of microRNAs and transcription factors in iAs-associated diabetes, and also human samples to identify extracellular vesicle microRNAs that serve as biomarkers. Results will advance understanding of diabetes pathophysiology related to iAs exposure and may open up novel therapeutic avenues for future investigation.

PI_NAMEs: SETHUPATHY, PRAVEEN  (contact)

PROJECT_TERMS: 3' Untranslated Regions;Address;Affect;Archives;Arsenic;Beta Cell;bioinformatics pipeline;Biological Assay;Biological Markers;Carcinogens;Cell Line;Cell Survival;Cells;Chromatin;Chronic;cohort;Collaborations;comorbidity;Complex;crosslinking and immunoprecipitation sequencing;Data;Defect;Diabetes Mellitus;diabetes risk;diabetic;diabetogen;diabetogenic;Disease;disease phenotype;disorder prevention;drinking water;Environmental Exposure;Environmental Risk Factor;Etiology;experimental study;exposed human population;Exposure to;extracellular vesicles;Food;Functional disorder;Future;gain of function;Genes;Genetic;Genetic Transcription;Goals;High-Throughput Nucleotide Sequencing;Human;Impairment;In Vitro;in vivo;inhibitor;Insulin Resistance;insulin secretion;insulin signaling;Intervention;Intestines;Investigation;islet;Islets of Langerhans;Knockout Mice;Knowledge;Laboratories;Link;Liver;locked nucleic acid;loss of function;Measures;Metabolic;Metabolic Diseases;Metabolic dysfunction;Methods;Methylation;microbiome composition;MicroRNAs;Modeling;Molecular;Molecular Target;mouse model;Mus;National Toxicology Program;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;overexpression;Pathway interactions;Persons;Phenotype;Plasma;Population Study;Prevalence;Privatization;Productivity;programs;Public Health;Publishing;Reporter Genes;Reporting;Research;RNA;Role;Running;Sampling;Signal Recognition Particle;Small RNA;Structure of beta Cell of islet;Superfund;superfund site;System;targeted treatment;Techniques;Testing;Tissues;Toxicology;transcription factor;Transcriptional Regulation;transcriptome sequencing;Transfer RNA;Untranslated RNA;Vision;Water

PROJECT_TITLE: Project 1:  Molecular Drivers of Arsenic- Induced Diabetes


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Precision Medicine;Stroke

ORG_CITY: TAMPA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: NARRATIVE  Ischemic strokes are a major worldwide cause of death and long-term disability in part because of an inability to optimize treatments before ischemic damage becomes permanent. This proposal uses a new noninvasive bedside optical instrument to measure cerebral perfusion changes during endovascular therapy for acute ischemic strokes and monitor functional biomarkers of cerebral tissue health for 24 hours after therapy. Clinical application of this research will enable neurologists to identify complications due to endovascular therapy before injuries manifest in the brain, leading to personalized care and better treatment outcomes.

PI_NAMEs: MOKIN, MAXIM ;PARTHASARATHY, ASHWIN BHARADWAJ  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;Address;Affect;Angiography;Biological Markers;Blood flow;blood flow measurement;Blood Pressure;Brain;Brain Edema;Brain Injuries;Caring;Catheters;Cause of Death;Cephalic;cerebral artery;Cerebral cortex;Cerebral hemisphere hemorrhage;Cerebral Infarction;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Physiology;Cerebrum;Classification;Clinical;clinical application;clinical imaging;Coagulation Process;cohort;Complication;computerized data processing;Diagnosis;Diffuse;Disease;Distal;efficacy evaluation;endovascular thrombectomy;Favorable Clinical Outcome;Goals;Head;Health;hemodynamics;Hemorrhage;Homeostasis;Hour;Human;Image;Imaging Device;imaging modality;Imaging technology;Impairment;improved;individual patient;Infarction;Injury;innovation;instrument;Ischemia;ischemic injury;Ischemic Stroke;Knowledge;Length;Long term disability;Malignant - descriptor;Measurement;Measures;Modeling;Monitor;Morbidity - disease rate;mortality;Near-Infrared Spectroscopy;Neurologist;non-invasive monitor;Optical Instrument;Optics;Outcome;Patient-Focused Outcomes;Patients;Perfusion;personalized care;personalized medicine;Phase;Physicians;Physiological;precision medicine;predict clinical outcome;prevent;Procedures;radiological imaging;Recovery;Regression Analysis;Regulation;Reperfusion Injury;Reperfusion Therapy;Research;response;revascularization;Scheme;Severities;Spectrum Analysis;standard of care;stroke recovery;Technology;temporal measurement;thrombolysis;Time;Tissues;tool;treatment optimization;Treatment outcome

PROJECT_TITLE: Noninvasive monitoring of cerebrovascular autoregulation during and after endovascular therapy for acute ischemic stroke

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(91)S]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: Newark

ORG_DEPT: BIOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: NARRATIVE  Activation of EGFR and other RTK signaling pathways represents a key aspect of tumorigenesis in a broad range of human cancers, including lung cancer. In recent years, targeted EGFR tyrosine kinase inhibitor therapies have been successful in treating lung cancers, but unfortunately the effectiveness of these and other targeted drugs tends to be limited in time, with the almost inevitable appearance of resistant tumors and the resulting dismal 5-year survival rate, with over 130,000 deaths per year.  We propose to develop an alternative approach to suppress EGFR signaling in treatment-refractory lung cancer, which would also be applicable to any other cancer dependent on EGFR signaling. This strategy is based on the rational design of antisense drugs that re-program EGFR gene expression to replace the oncogenic EGFR isoforms with potent inhibitory, naturally existing soluble decoy EGFR variants, both when the EGFR pathway is driven by EGFR-activating mutations, or by wild-type EGFR overexpression.

PI_NAMEs: CARTEGNI, LUCA  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Affect;Alternative Splicing;Antibodies;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Appearance;autocrine;Automobile Driving;Biodistribution;Biological;Biological Models;Bypass;Cancer Etiology;Cancer Model;Cell Line;Cells;Cessation of life;Chemistry;Clinical Trials;Colorectal Cancer;Data;Dendrimers;design;Development;Dimerization;Disease Resistance;Dominant-Negative Mutation;drug development;Drug Kinetics;Drug resistance;Drug Targeting;Effectiveness;EGF gene;EGFR gene;EGFR inhibition;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;epidermal growth factor receptor VIII;ERBB2 gene;Excision;experimental study;extracellular;Future;Gene Expression;Generations;Glioblastoma;Heterodimerization;Human;In Vitro;in vivo;inhibitor;inhibitor therapy;Introns;Investigation;knock-down;Lead;Length;Ligand Binding;Ligand Binding Domain;Ligands;Malignant neoplasm of lung;Malignant Neoplasms;Methodology;Methods;Modeling;mouse model;mutant;Mutate;Mutation;mutational status;nanoparticle delivery;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;novel drug class;Oncogenic;overexpression;paracrine;Pathologic;Pathway interactions;Pattern;Peptides;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Play;Polyadenylation;Positioning Attribute;Preparation;programs;Property;Protein Isoforms;protein purification;rational design;receptor;Receptor Protein-Tyrosine Kinases;Recombinant Proteins;Refractory;Relapse;Residual state;Resistance;resistance mechanism;RNA;RNA Splicing;Role;Safety;Signal Pathway;Signal Transduction;Specificity;STAT3 gene;success;Survival Rate;System;targeted cancer therapy;Testing;Therapeutic;Time;tool;Toxic effect;Transcript;Transmembrane Domain;Treatment Protocols;treatment response;tumor;tumorigenesis;Tyrosine Kinase Inhibitor;Variant;Xenograft procedure

PROJECT_TITLE: Targeting Refractory EGFR-Driven Tumors By Induction Of Dominant-Negative EGFR Splicing Variants

STUDY_SECTION: BMCT

STUDY_SECTION_NAME: Basic Mechanisms  of Cancer Therapeutics Study Section[BMCT]


PHR: NARRATIVE: PROJECT 2 The proposed research is relevant to public health protection and the NIEHS Superfund Program as it will study the interactions between genetics, sex and obesity in diabetes induced by chronic exposure to inorganic arsenic. Inorganic arsenic is the highest priority ATSDR chemical currently affecting millions of people around the world, including in North Carolina.

PI_NAMEs: PARDO-MANUEL DE VILLENA, FERNANDO  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Affect;Arsenic;Beta Cell;Body Composition;Body Weight;Cell Physiology;Chemicals;Chronic;Diabetes Mellitus;diabetes risk;diabetic;diabetogen;diabetogenic;Disease;disorder prevention;disorder risk;Dose;drinking water;epidemiology study;Etiology;Experimental Designs;Exposure to;Fasting;Female;Food;Gene Expression;Genetic;Genetic Polymorphism;genetic risk factor;Genetic Variation;Genotype;glucose tolerance;Goals;Health;health assessment;Health protection;High Fat Diet;high risk;Human;human disease;Hyperglycemia;inhibitor;Insulin Resistance;insulin signaling;Islets of Langerhans;Laboratories;Link;Liver;male;Measures;Messenger RNA;Metabolic;Metabolic dysfunction;Metabolism;Methods;Methylation;Methyltransferase;Microbe;microbial;microbiome;MicroRNAs;Modeling;Molecular Biology;Molecular Profiling;Mouse Strains;Mus;National Institute of Environmental Health Sciences;Non obese;Non-Insulin-Dependent Diabetes Mellitus;North Carolina;novel;obese person;Obesity;Other Genetics;Outcome;Persons;Phenotype;Population;Predisposition;programs;Public Health;Research;Resources;response;Risk;Risk Factors;Role;sex;Signal Recognition Particle;Small RNA;statistics;Superfund;synergism;Techniques;Testing;Tissues;Toxic Environmental Substances;Toxicology;transcriptomics;Translating;Urine;Variant;Vision;Water

PROJECT_TITLE: Project 2: Arsenic- Obesity- Diabetes Interactions


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Data Science;Genetics;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: DURHAM

ORG_DEPT: MISCELLANEOUS

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The polymorphic nature of Plasmodium antigen targets of immunity poses major challenges to malaria vaccine development efforts. This study leverages parallel analysis of parasite antigenic variation and variant-specific host antibody responses in a multi-year longitudinal study of a consistent cohort in order to triangulate variant positions and epitopes that contribute to protective immunity. This work will inform rational design of effective multivalent malaria vaccines targeting variants most critical for protection.

PI_NAMEs: MARKWALTER, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Age;Amino Acid Sequence;Amino Acids;Antibodies;Antibody Response;Antigen Targeting;Antigenic Variation;Antigens;Biological Markers;C-terminal;career;career development;Catalogs;Chemistry;Child;circumsporozoite protein;Clinical;cohort;Cohort Studies;Collaborations;combinatorial;Combinatorics;cross immunity;cross reactivity;Data;Data Science;Data Set;deep sequencing;design;Development Plans;Discipline;Environment;Epidemiology;Epitopes;Exhibits;Exposure to;Face;field study;Funding;Future;genetic epidemiology;Genetic Polymorphism;Genotype;Goals;Haplotypes;high dimensionality;Immune response;Immune Targeting;Immunity;immunogenic;Immunology;improved;in silico;Incidence;Individual;Infection;Informatics;Institution;Kenya;Link;Longitudinal Studies;Malaria;Malaria Vaccines;Measurement;Measures;Mentors;Molecular Epidemiology;mortality;National Institute of Allergy and Infectious Disease;Nature;next generation;Parasites;Participant;Pattern;Peptides;Phenotype;Plasmodium;Plasmodium falciparum;Population;Positioning Attribute;Preventive vaccine;Proteins;Protocols documentation;rational design;Recording of previous events;Resources;response;Sampling;Scientist;screening;Serology;seropositive;Structure;Time;Training;training opportunity;Translational Research;United States National Institutes of Health;vaccine candidate;Vaccine Design;vaccine development;Vaccines;vaccinology;Variant;Work

PROJECT_TITLE: Synthesizing immunoinformatics and genetic epidemiology to identify signatures of natural functional immunity to malaria parasites

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


PHR: NARRATIVE: PROJECT 3 The proposed research is relevant to global public health and the national Superfund program as it will study the role of gut microbiome in inorganic arsenic-induced diabetes. Inorganic arsenic is the highest priority contaminant of ATSDR and is affecting millions of people around the world, including vulnerable populations in North Carolina.

PROJECT_TERMS: Address;adverse outcome;Affect;Agonist;Animals;Arsenic;Attenuated;Bacteria;bile acid metabolism;Bile Acids;bile salts;Black Raspberry;Cholic Acids;commensal bacteria;Coupled;Data;Deoxycholic Acid;Diabetes Mellitus;Diabetes prevention;diabetes risk;Diet;dietary supplements;Disease;disorder prevention;dysbiosis;epidemiology study;exposed human population;Exposure to;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Genes;Germ-Free;Gluconeogenesis;Glucose;glucose tolerance;gut bacteria;gut microbiome;gut microbiota;Health;Hepatic;Hepatocyte;Homeostasis;host microbiome;Human;human disease;Hydrolase;ileum;Impairment;improved;In Vitro;in vivo Model;innovation;Insulin;insulin signaling;Intervention;knock-down;Knock-out;Knowledge;Link;Lithocholic Acid;Mediating;Metabolic;Metabolic dysfunction;Metabolism;Metagenomics;Methods;microbiome;microbiome alteration;microbiome research;microbiome therapeutics;microbiota transplantation;Molecular;Mus;Nature;North Carolina;novel;Pathogenesis;Pathway interactions;Persons;Population;programs;Public Health;receptor;Receptor Activation;Receptor Inhibition;Regulation;Regulator Genes;Research;Role;Shapes;Shotguns;Signal Recognition Particle;Signal Transduction;Signaling Molecule;Superfund;Symptoms;Techniques;Testing;Therapeutic;Tissues;Toxic effect;Toxic Environmental Substances;Vision;Vulnerable Populations

PROJECT_TITLE: Project 3: Gut microbiome -arsenic- diabetes interactions


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Maternal Health;Pediatric;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The primate-specific miRNA cluster, C19MC, has roles in trophoblast invasion and migration, but the roles of these miRNAs in primate embryonic development and early placentation remains to be elucidated. Our proposal aims to determine the gene networks controlled by the primate- specific C19MC miRNA cluster in primate placental lineage specification and development utilizing rhesus macaque embryos, primary trophoblasts, and trophoblasts stem cells. Understanding the roles of the C19MC in early placentation may lead to the use of these miRNAs as diagnostic tools in maternal blood, and as therapeutic agents in developing placental therapies in experimental animal models.

PI_NAMEs: SCHMIDT, JENNA ANN (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Adult;Blood;cardiovascular disorder risk;career development;Cell Line;cell type;Child Health;Chromosome 19;Chromosome abnormality;Chromosome Mapping;Communities;Competence;Development;diagnostic tool;Embryo;Embryonic Development;embryonic stem cell;Environment;Ethics;experience;Experimental Animal Model;experimental study;Fertilization in Vitro;fetal;Fetal Growth Retardation;fetal programming;Fetus;Gene Expression;Gene Expression Regulation;gene network;gene therapy;Genes;genome editing;Goals;Health;Human;implantation;improved;in utero;In Vitro;in vivo;innovation;Invaded;Knowledge;life span;Macaca;Macaca mulatta;Maps;member;Mentors;Methods;MicroRNAs;migration;Modeling;Modification;mRNA Expression;nonhuman primate;Outcome;overexpression;Pathology;Pathway interactions;Personal Satisfaction;Phase;Placenta;placental stem cell;Placentation;Pre-Eclampsia;Pre-implantation Embryo Development;precision medicine;Pregnancy;Pregnancy Complications;primate development;Primates;Repression;Research;research and development;Resources;Rhesus;RNA;Role;Scientist;Specific qualifier value;stem;Therapeutic;Therapeutic Agents;tool;Transcend;trophoblast;trophoblast stem cell;Universities;Wisconsin

PROJECT_TITLE: Primate-specific miRNAs in Embryonic and Placental Development

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


PHR: NARRATIVE: PROJECT 4 Project 4 focuses on understanding the biogeochemical processes that result in solubilization of inorganic arsenic (iAs) and other oxyanion-forming elements of concern to human health (V, Cr). By coupling traditional field and laboratory geochemical approaches to cutting-edge spectroscopic and modeling techniques, we will develop an improved fundamental understanding of the geochemical factors that result in iAs, V, and Cr solubilization from the molecular to regional scales. The knowledge gained will allow for the development of predictive tools to reduce human exposure and improve management of these common geogenic and anthropogenic contaminants.!

PI_NAMEs: DUCKWORTH, OWEN  (contact)

PROJECT_TERMS: Address;anthropogenesis;Area;Arsenic;Awareness;Chemicals;Consumption;contaminated water;Coupling;density;Detection;Development;Diabetes Mellitus;disorder prevention;drinking water;Elements;Environment;exposed human population;Exposure to;fundamental research;Future;geochemistry;ground water;Guide prevention;Guidelines;Health;Heterogeneity;Human;improved;insight;Intervention;Knowledge;Laboratories;land use;Link;Location;Measurement;Metabolic Diseases;Metabolic dysfunction;Methods;Modeling;Molecular;Monitor;Nitrates;North Carolina;novel;Oxidants;Oxidation-Reduction;Oxides;Persons;Pollution;Population;Population Growth;predictive tools;Predisposition;Process;programs;Province;Public Health;Reaction;remediation;Research;Risk;Risk Assessment;risk prediction;Sampling;Signal Recognition Particle;simulation;Site;Soil;Solid;Solubility;Source;stem;Study models;suburb;Superfund;superfund site;System;Techniques;Thermodynamics;tool;Trace Elements;Urbanization;Vision;wasting;Water;Water consumption;water sampling;well water;Wood material;Work

PROJECT_TITLE: Project 4: Geochemical Predictors of Arsenic Contamination


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Dietary Supplements;Natural Products

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The structural protein, collagen, is a main component of dentin and plays a major role in the longevity of adhesive-based tooth reparative therapies of dental caries, which is highly prevalent in our population. Building on insights with plant-derived phenolic compounds in the group of tannins and using a bio-inspired modular agent strategy, this project will develop other naturally occurring plant phenols into new classes of dentin biomodulators for future preclinical development. The ultimate goal is to improve oral health by reducing the incidence of failing dental restorations and, thereby, reduce the pain and anxiety associated with dental procedures and reduce health care costs.

PI_NAMEs: BEDRAN-RUSSO, ANA KARINA B;PAULI, GUIDO F (contact)

PROJECT_TERMS: Adhesions;Adhesives;Adopted;Aging;Anxiety;Biochemical;Biocompatible Materials;Biodegradation;Biological;Biological Response Modifiers;biomaterial compatibility;biomechanical test;Biomechanics;Biomimetics;Carbon;Cells;Characteristics;Chemicals;Chemistry;Clinical;clinical application;Collagen;Collagen Type I;Color;Complex;Data;Dental;Dental Care;Dental caries;Dental Enamel;Dental Pulp;dental structure;Dentin;Dentistry;design;Development;dimer;Economics;Extracellular Matrix;Failure;Ferns;Foundations;Future;Goals;Health Care Costs;Healthcare;Human;Hydrogen Bonding;improved;Incidence;innovation;insight;Interdisciplinary Study;Intervention;Longevity;Mechanics;Methodology;Methods;Minerals;Molecular;Mouth Diseases;Natural Products;Natural Source;New Agents;novel;Oral;Oral health;oral infection;Outcome;oxidation;pain reduction;Pattern;Performance;Personal Satisfaction;Pharmacy facility;Phase;Phenols;Phloroglucinol;Phytochemical;Plant Resins;Plant Sources;Plants;Play;polymerization;Polymers;Population;preclinical development;preclinical study;premature;Proanthocyanidins;Property;restoration;restorative dentistry;Role;scaffold;Skeleton;soft tissue;Solid;Source;Structural Protein;Structure;Surface;Tannic Acid;Therapeutic;Tissues;tool;Tooth structure;Vascular Plant;Vitis

PROJECT_TITLE: Modularity in Oligomeric Phenol Chemistry for Biomodulation of Dental Structures


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Prevention

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Many genetic variants have been associated with psychiatric disorders such as schizophrenia, but the biological effects of these variants -- and the mechanisms through which they impart risk for disease -- remain largely unknown. Substantial efforts have recently been undertaken to compile functional genomic data (e.g. genetic variation, gene expression, splicing) across a large number of human brain samples. Here, we develop and apply new techniques to directly integrate these reference brain genomic annotations with psychiatric disease- associated genetic variation to gain new insights into the neurobiological mechanisms associated with these disorders.

PI_NAMEs: GANDAL, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Address;Adult;Affect;Alternative Splicing;Area;autism spectrum disorder;Biological;Biological Process;Brain;Candidate Disease Gene;candidate validation;Cell Line;cell type;Cells;Chromosome Mapping;Communities;Complex;CRISPR/Cas technology;Data;Development;differential expression;Disease;disorder risk;Ensure;Event;Exhibits;fetal;functional genomics;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Risk;genetic variant;Genetic Variation;Genets;Genome engineering;genome resource;genome wide association study;genome-wide;Genomic approach;genomic data;genomic locus;Genomics;Genotype;Heritability;Human;Individual;insight;Intervention;Knock-in;Link;Linkage Disequilibrium;Maps;Mental disorders;Methods;nerve stem cell;neurobiological mechanism;Neurobiology;neurogenetics;Neurons;neuropsychiatry;new therapeutic target;novel;Pathogenesis;Pattern;Phenotype;precision medicine;Protein Isoforms;Proteomics;Quality Control;Quantitative Trait Loci;Regulation;repaired;Reporting;Reproducibility of Results;Resolution;Resources;Risk;risk variant;RNA;RNA Splicing;Sampling;Schizophrenia;Science;Signal Transduction;Specificity;targeted treatment;TCF7L2 gene;Techniques;therapeutic development;Therapeutic Intervention;Tissue-Specific Gene Expression;Tissues;trait;Transcript;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;Uncertainty;Variant;Work

PROJECT_TITLE: Isoform-level probabilistic transcriptome-wide association to undercover neurogenetic mechanisms underlying complex psychiatric traits

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


PHR: NARRATIVE: PROJECT 5 Geogenic and anthropogenic contaminants (e.g., inorganic arsenic, manganese, chromium, and vanadium) infiltrate private wells, placing residents at risk for health outcomes (e.g., metabolic disorder/diabetes associated with inorganic arsenic exposure). Project 5 aims to optimize membrane- and sorbent-based treatment technologies to reduce exposure to inorganic arsenic and co-occurring contaminants. To this end, we will develop an integrated membrane-sorbent system and evaluate its performance in North Carolina households served by contaminated groundwaters.

PI_NAMEs: CORONELL NIETO, ORLANDO  (contact)

PROJECT_TITLE: Project 5: Novel Filtration Devices for Arsenic Reduction


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The main objectives of this proposal are to create a coherent analytical framework tailored for integration of available and novel multiomics resources for brains and Alzheimer’s disease (AD), to identify causal variants and genes, and to characterize the genetic profile of AD patients at different molecular levels across brain tissues. By identifying novel causal effects attributable to molecular functions, our result will provide insight for development of therapeutic drugs specifically targeting at cellar process. The multiomics risk profile built for AD patients will improve clinical trial designs for AD drug development, paving the path to personalized therapeutics.

PI_NAMEs: WANG, GAO  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Acylation;Address;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Atlases;Bayesian Modeling;Bioinformatics;Brain;brain tissue;causal variant;cell type;Clinical Trials Design;Code;cohort;Collection;Complex;computerized tools;Data;data integration;data resource;design;Disease;Disease susceptibility;disorder subtype;drug development;Drug Targeting;endophenotype;Engineering;epigenomics;Etiology;Family;functional genomics;gene discovery;Gene Expression;Genes;Genetic;genetic association;Genetic Diseases;Genetic Heterogeneity;Genetic study;genetic variant;Genome Mappings;genome wide association study;genome-wide;Genomic Segment;Goals;Heterogeneity;Histones;Human;improved;Individual;individual patient;insight;Investigation;Late Onset Alzheimer Disease;Maps;Methods;Methylation;methylation pattern;model building;Modeling;Molecular;molecular phenotype;multi-ethnic;Multiomic Data;multiple omics;Multivariate Analysis;novel;novel strategies;Pathogenesis;Pathogenicity;Pathway interactions;Patient risk;Patients;Performance;personalized therapeutic;Pharmaceutical Preparations;Polyadenylation;polygenic risk score;Population;Process;Proteomics;Quantitative Trait Loci;Research Design;Resources;Risk;risk prediction;Sampling;Series;Signal Transduction;Single Nucleotide Polymorphism;Site;Software Engineering;Statistical Models;success;Susceptibility Gene;Testing;therapeutic development;Time;Tissues;trait;transcriptome sequencing;Universities;Untranslated RNA;Variant;whole genome

PROJECT_TITLE: Multiomics data integration methods to discover putative causal variants, genes and patient heterogeneity for Alzheimers disease

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Despite the proven antidepressant effectiveness of electroconvulsive therapy (ECT) for depressive episodes, procedure-related cognitive impairment (memory) prolongs the period of functional impairment (e.g., unable to work) and delays recovery from severe depressive episodes. This project proposes a novel method of individualized and precise ECT dosing with amplitude titration informed by electric field modeling and neuroimaging. The contribution of the proposed research is expected to create consistent and effective dosing at the amplitude “sweet spot” of antidepressant response with cognitive safety for late-life depression.

PI_NAMEs: ABBOTT, CHRISTOPHER C (contact)

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: Adverse effects;Age;Anatomy;anti-depressive agents;arm;Brain;BRAIN initiative;brain tissue;Cephalic;Clinical;clinical practice;Cognitive;Cognitive deficits;cranium;Data;Depressed mood;depressed patient;Depressive disorder;depressive symptoms;Devices;Dose;Effectiveness;electric field;Electroconvulsive Therapy;Electrodes;Equilibrium;FDA approved;Frequencies;Functional impairment;geriatric depression;Goals;Hippocampus;Impaired cognition;improved;Liquid substance;Memory;Mental Depression;Methods;Modeling;Moods;neuroimaging;Neuronal Plasticity;neuroregulation;novel;older adult;Outcome;Output;Physiologic pulse;Procedures;Randomized;Randomized, Controlled Trials;Recovery;Research;response;Risk;Safety;Seizures;Series;Skin;Spatial Distribution;Spottings;Stimulus;Titrations;Training;Translational Research;treatment arm;treatment response;verbal;Width;Work

PROJECT_TITLE: Electroconvulsive therapy amplitude titration for improved clinical outcomes in late-life depression


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunotherapy;Lung;Lung Cancer

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE KRAS mutant lung cancer is a leading cause of cancer mortality in the United States, and a lung cancer subtype for which targeted agents, such as MEK inhibitors, have not made significant clinical progress. Based upon the preliminary data from the investigators, we propose: 1) to study the role and reversibility of epithelial- mesenchymal transition (EMT) in KRAS mutant lung cancer to confer resistance to MEK inhibitors, ii) evaluate the effects of MEK inhibitors on the tumor immune microenvironment and the therapeutic vulnerabilities that arise due to immune checkpoint upregulation in pre-clinical models, and iii) characterize the immune-related markers associated with EMT/MAPK activation and investigate the markers of sensitivity/resistance to combination anti-PD-L1 and MEK inhibitor treatment in patient tumor samples.

PI_NAMEs: GIBBONS, DON LYNN (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Address;anti-PD-L1;Bioinformatics;Biometry;Cancer Etiology;Cancer Patient;cancer subtypes;Carcinoma;Clinical;Clinical Oncology;Clinical Trials;co-clinical trial;Complex;Data;Data Analyses;DNA Sequence Alteration;drug development;efficacy evaluation;efficacy testing;Epidermal Growth Factor Receptor;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Genetically Engineered Mouse;Heterogeneity;Histone Deacetylase Inhibitor;Human;human model;Hylobates Genus;Immune;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune signaling;Immunologic Tests;Immunotherapy;in vivo evaluation;inhibitor;K-ras mouse model;kinase inhibitor;Knowledge;KRAS2 gene;Lung Adenocarcinoma;Malignant neoplasm of lung;MAP Kinase Gene;MAPK Signaling Pathway Pathway;Mediating;MEKs;member;Mesenchymal;MicroRNAs;molecular pathology;mortality;mouse model;multidisciplinary;mutant;Mutate;Mutation;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;Oncogenic;Operative Surgical Procedures;Pathway interactions;Patients;PD-1/PD-L1;Phenotype;pre-clinical;Pre-Clinical Model;Productivity;Publishing;Ras/Raf;Regulation;Research Personnel;Resected;Resistance;Resistance development;response;response biomarker;Role;Sampling;Signal Pathway;Signal Transduction;small molecule;Specimen;targeted agent;Testing;Therapeutic;Translating;treatment response;tumor;tumor heterogeneity;tumor-immune system interactions;Tumor-infiltrating immune cells;United States;Up-Regulation

PROJECT_TITLE: The Role of Epithelial-Mesenchymal Transition in Re-Wiring KRAS Mutant Lung Cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cooley's Anemia;Genetics;Hematology;Human Genome;Orphan Drug;Rare Diseases;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Narrative This application seeks to study the biological functions and mechanism of action of a newly identified molecule called HIC2 that we found to regulate the transition of the fetal to the adult form of hemoglobin synthesis in red blood cells. Raising fetal hemoglobin in patients with sickle cell disease and some forms of thalassemia improves outcomes and has been an important therapeutic goal in the field for many years. The proposed studies aim to deepen our knowledge of the hemoglobin switching mechanism with ramifications for the treatment of hemoglobinopathies.

PI_NAMEs: BLOBEL, GERD A (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Adult;Animal Model;Animals;Basic Science;BCL11A gene;beta Thalassemia;Binding;Biological Assay;Biological Process;Biology;Cell Culture Techniques;cell type;Cells;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;cofactor;Complement;Core Facility;CRISPR/Cas technology;Cultured Cells;Data;Dedications;Development;Developmental Gene;DNA Binding;Elements;Engraftment;Enhancers;Erythroblasts;Erythrocytes;Erythroid;Erythroid Cells;experimental study;fascinate;fetal;Fetal Hemoglobin;Fetal Liver;follow-up;Foundations;gain of function;GATA1 gene;Gene Expression;gene therapy;Genes;Genetic;Genetic Enhancer Element;Genetic Screening;Genetic Transcription;Globin;Goals;Hematological Disease;Hematopoiesis;Hematopoietic stem cells;Hemoglobin;Hemoglobinopathies;Heterozygote;histone modification;Histones;Human;improved outcome;In Vitro;in vivo;insight;interest;Knockout Mice;Knowledge;loss of function;Measurement;Measures;Mediating;Messenger RNA;Modeling;Molecular;Mus;novel;novel therapeutics;NuRD complex;offspring;Outcome;overexpression;Patients;posttranscriptional;Process;Production;programs;promoter;Proteins;Regulation;Regulatory Element;Reporter;Reporting;Repression;Role;Sickle Cell Anemia;Solid;TAL1 gene;Thalassemia;Therapeutic;transcription factor;Transcription Repressor;Transcriptional Regulation;transcriptome;transcriptome sequencing;Translating;Umbilical Cord Blood;Up-Regulation;Xenograft Model;Yolk Sac

PROJECT_TITLE: Regulation of Hemoglobin Switching

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Spinal Muscular Atrophy

ORG_DEPT: PATHOLOGY

PHR: Breakthrough SMN- inducing therapies have recently been approved by FDA for the treatment of SMA. However, they do not provide a cure and therapeutic approaches that address unmet needs of SMA patients by enhancing the clinical benefit of SMN- inducing therapies through combinatorial treatment are highly sought after. To address this issue, our project aims to elucidate the mechanisms underlying the initiation and execution of motor neuron degeneration in SMA as well as establish the therapeutic potential of SMN-independent, pharmacological targeting of this pathway for neuroprotection.

PI_NAMEs: PELLIZZONI, LIVIO  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Address;Automobile Driving;Brain;candidate marker;Cessation of life;Clinical;combinatorial;Disease;Disease Marker;disease model;druggable target;Event;FDA approved;Functional disorder;Gene Delivery;Gene Expression;Genes;Genetic;Goals;Immunohistochemistry;Infant Mortality;inhibitor;Injections;insight;knock-down;Knowledge;Link;MAP Kinase Gene;Mediating;Monitor;Morphology;Motor;motor neuron degeneration;Motor Neurons;mouse model;Mus;N-terminal;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;neuroprotection;novel;p38 Mitogen Activated Protein Kinase;Pathogenicity;Pathology;Pathway interactions;Patients;Permeability;pharmacologic;Phenotype;Phosphorylation;preservation;prevent;Process;Protein Isoforms;Publishing;restoration;Severity of illness;skeletal muscle wasting;SMN deficiency;SMN expression;SMN protein (spinal muscular atrophy);Spinal Muscular Atrophy;spinal pathway;Synapses;Testing;Therapeutic;therapeutic target;TP53 gene;transcriptome sequencing;treatment effect;Up-Regulation;Work

PROJECT_TITLE: Mechanisms and Therapeutic Targeting of Motor Neuron Death in SMA

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Pediatric

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative We seek to understand how parents transmit their anxiety-related thinking patterns to their children. Data from this project will directly inform future studies testing parent-focused treatments for child anxiety. The long-term goal is to improve mental health and functioning in both children and their parents.

PI_NAMEs: ELIAS, COURTNEY BEARD (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: Address;Adult;Age;Anxiety;Anxiety Disorders;anxiety symptoms;anxiety treatment;anxious;behavior measurement;Behavioral;Brain;Cellular Phone;Child;Child Rearing;Cognitive;comparison control;coping;Data;design;Development;Distal;Distant;Ecological momentary assessment;Educational process of instructing;experience;Fathers;Feedback;Future;Gender;Goals;Health Services Accessibility;improved;intergenerational;Intervention;Knowledge;life span;Measures;Mediating;Mental disorders;mental function;Mental Health;Methodology;Modeling;Mothers;National Institute of Mental Health;Negative Valence;novel;Observational Study;Outcome;parental role;Parents;Patient Self-Report;Patients;Pattern;personalized intervention;personalized medicine;Physiological;Probability;Provider;psychologic;racial identity;Randomized;Research Domain Criteria;Risk Factors;Self Assessment;smartphone application;Speech;Strategic Planning;System;Techniques;Testing;Theoretical model;theories;Thinking;Time;Translating;transmission process;United States;Visit;Work;Youth

PROJECT_TITLE: Parent interpretation bias as a key mechanism of intergenerational transmission of anxiety

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Prevention;Sleep Research

ORG_CITY: KNOXVILLE

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: PROJECT NARRATIVE Obesity is a complex disease, and innovative treatments that use a biobehavioral framework, such as focusing on time-based energy intake goals (how energy intake is distributed across the day) may enhance initial and longer-term (12-month) weight loss. Time-based dietary goals are believed to promote synchronization of biological and behavioral circadian rhythms, and determining the health benefits of these goals is an objective of NIH’s nutrition strategic plan. This investigation is a randomized controlled trial designed to examine the effect of time-based energy intake goals on longer-term (12-month) weight loss, sleep regularity, and appetite regulation; if enhanced appetite regulation mediates the relationship with weight loss; and if chronotype moderates the effects.

PI_NAMEs: RAYNOR, HOLLIE A (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: actigraphy;Address;Adult;Appetite Regulation;biobehavior;Biological;Body Weight Changes;Body Weight decreased;Cellular Phone;Characteristics;circadian;circadian behavioral rhythms;Circadian Rhythms;Cognitive Therapy;Complex;Consumption;Continuous Glucose Monitor;Diet;dietary;Dietary Fats;digital imaging;Disease;Eating;Ecological momentary assessment;Energy Intake;Fatty acid glycerol esters;Goals;Health Benefit;Hunger;Individual;innovation;Intake;Intervention;Investigation;Length;lifestyle intervention;Literature;Long-Term Effects;Maintenance;Measures;Mediating;Mediator;novel;nutrition;Obesity;obesity treatment;Outcome;Overweight;Participant;Patient Self-Report;Pattern;Physical activity;precision nutrition;Randomized;Randomized, Controlled Trials;Sleep;sleep onset;Strategic Planning;Testing;Time;trial design;United States National Institutes of Health;vigorous intensity;Weight Gain;Work

PROJECT_TITLE: Effect of time-based energy intake goals on weight loss during obesity treatment.

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: There is a great unmet need for human model systems to study biological processes involving complex interactions between diverse tissues within an organ. For example, there are many physiopathological processes related to the human intestine that involve cross-talk between tissue types, such as Hirschsprung’s disease, which is a congenital lack of enteric neurons affecting 1 in 5,000 births, that renders smooth muscle within the gut unable to contract. We present compelling preliminary data for a novel iPSC-derived human intestinal organoid (HIO) model that can co-differentiate as a complex multilineage tissue possessing an epithelium, a mesenchymal/stromal layer that includes organized smooth muscle, endothelial cells and enteric neurons - the first complex HIO model from iPSCs to co-differentiate tissues from all 3 embryonic germ layers in one model system.

PI_NAMEs: SPENCE, JASON  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: 3-Dimensional;abdominal wall;Adhesions;Affect;Bar Codes;Biological Models;Biological Process;Birth;Blood flow;Blood Vessels;Cell Differentiation process;Cell Nucleus;cell type;Cells;Complex;Congenital Megacolon;Contracts;Cues;Data;Development;disease model;Embryo;Endoderm;Endothelial Cells;Endothelium;Enteral;Environment;Epidermal Growth Factor;Epithelium;experimental study;Extracellular Matrix;Family;Family member;Germ Layers;Goals;Growth;Heterogeneity;Human;human induced pluripotent stem cells;human model;Immunocompromised Host;improved;In Vitro;in vivo;induced pluripotent stem cell;Intestines;Lead;matrigel;member;Mesenchymal;Mesenchyme;Mesoderm;Mesothelium;Messenger RNA;Methods;Microfluidics;mimetics;Modeling;monolayer;Motion;multiple omics;Mus;Nerve Tissue;neural;Neurons;novel;Organ;Organoids;Patients;Phenotype;Population;prevent;Process;Resolution;self organization;Series;Serous Membrane;Signal Pathway;single cell analysis;single-cell RNA sequencing;Smooth Muscle;Smooth Muscle Myocytes;spheroids;stem cell niche;Suspension Culture;System;temporal measurement;Testing;Thinness;Time;Tissue Differentiation;Tissues;Transplantation;Vascular Smooth Muscle;Vascularization;Villus;XCL1 gene

PROJECT_TITLE: Human iPSC intestine mimetics with integrated mesenchymal, endothelial and enteric nervous tissue

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Clinical Research;Rheumatoid Arthritis

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Aging of the immune system renders older adults susceptible to cancer, infections, neurodegeneration and cardiovascular disease. To turn aging into a modifiable condition, we need to understand the molecular alterations that lead to immune system aging. This project builds on data showing that T cells from older adults have leaky mitochondria, releasing bacterial motifs that trigger inappropriate tissue inflammation, and will use sophisticated bioassays to develop novel biomarkers and novel treatments to improve age-related disease outcomes in older humans.

PI_NAMEs: WEYAND, CORNELIA M. (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Affect;Age;age related;age-related disease;aged;Aging;aging related;Amino Acids;anti aging;Autoimmune Diseases;Bacteria;Bacterial Proteins;Bioenergetics;Biological Assay;Biological Markers;Biological Models;Biological Process;Cardiovascular Diseases;CD4 Positive T Lymphocytes;cell age;Cell Aging;Cells;Cessation of life;Citric Acid Cycle;Cohort Studies;Communication;Competence;Complex;Containment;Cues;Cytosol;Data;Defect;Deterioration;Disease;Disease Outcome;disorder risk;DNA Damage;druggable target;Effector Cell;effector T cell;Elderly;Electron Transport;endosymbiont;Ensure;exosome;Extravasation;Failure;Fibroblasts;Generations;Genomic Instability;Goals;Human;human disease;human tissue;Immune;Immune system;Immunity;immunodeficiency;Immunologic Markers;improved;in vivo;Infection;Inflammation;Inflammatory;Innate Immune Response;Innate Immune System;Inner mitochondrial membrane;Intervention;Knowledge;late endosome;Lysosomes;Macrophage;Malignant Neoplasms;Maps;Methionine;Mitochondria;Mitochondrial DNA;Mitochondrial Matrix;mitochondrial permeability transition pore;Mitochondrial Proteins;Molecular;Molecular Analysis;mortality;mouse model;N-terminal;Natural Immunity;Nerve Degeneration;novel;novel marker;older adult;Older Population;Organelles;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phenotype;polypeptide;Population;Positioning Attribute;Predisposition;premature;Premature aging syndrome;prevent;Process;Production;Property;proteostasis;Reagent;Recording of previous events;Refuse Disposal;release of sequestered calcium ion into cytoplasm;Rheumatoid Arthritis;Secure;Series;Signal Transduction;small molecule;solute;Stromal Cells;T cell differentiation;T-Lymphocyte;Testing;tissue repair;Tissues;trafficking;Vesicle;wasting

PROJECT_TITLE: Mitochondrial Malfunction in T Cell Aging and Tissue Inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VSR-I (S1)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Genetics;Heart Disease;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT HEALTH RELEVANCE STATEMENT Potentially lethal cardiac channelopathies associated with pathogenic variants in the RYR2-encoded cardiac ryanodine receptor type 2 (RyR2)/calcium release channel (CRC) are the pathogenic basis for a significant portion of autopsy-negative sudden unexplained death in the young (SUDY). Recently, we discovered a novel syndrome, that we have termed calcium release channel deficiency syndrome (CRCDS), in the Amish community that is responsible for highly penetrant, exertion-related sudden cardiac arrest and sudden cardiac death without an overt phenotype to suggest RYR2-mediated catecholaminergic polymorphic ventricular tachycardia (CPVT1), but stems from biogenic loss of function in RyR2 secondary to a homozygous duplication in RYR2 that causes a 70% reduction in RYR2 transcript/RyR2 protein levels. The purpose of this study is to determine the contribution of both biogenic- and biophysical-mediated CRCDS in SUDY, to identify genotype/phenotype correlates to assist in clinical diagnosis and management of patients with CRCDS, and to determine the underlying molecular and cellular mechanisms of CRCDS associated with potentially lethal arrhythmias.

PI_NAMEs: ACKERMAN, MICHAEL JOHN (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: 5' Untranslated Regions;Address;Amish;Arrhythmia;Autopsy;autosome;Biology;Biophysics;Caffeine;Calcium;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiology;Catecholaminergic Polymorphic Ventricular Tachycardia;Cell Line;Cell model;Cell Physiology;cell regeneration;Cessation of life;clinical diagnosis;Clinical Management;clinical phenotype;Code;Communities;comparison control;Coupling;Development;Disease;dosage;Echocardiography;Electrocardiogram;Electrophysiology (science);Engineering;Epinephrine;Event;Exercise;Exertion;Exons;Experimental Designs;Family member;Frequencies;gain of function;Generations;Genetic;genome sequencing;Genotype;Health;Heart;Heart Arrest;heart cell;Heart Diseases;Heritability;Heterozygote;Holter Electrocardiography;Hour;Hyperactivity;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Inherited;innovation;Integrase;Intergenic Sequence;International;Isoproterenol;Kinetics;Knowledge;Lead;Link;loss of function;Measurable;Mediating;Modeling;Molecular;Nature;novel;novel therapeutics;Pathogenicity;Patients;Phenotype;Promoter Regions;Property;protein expression;protein function;Proteins;Registries;Resolution;response;risk stratification;Ryanodine Receptor Calcium Release Channel;Secondary to;SERCA2a;Signal Transduction;small hairpin RNA;stem;Stress Tests;sudden cardiac death;Syncope;Syndrome;System;Testing;Transcript;Untranslated RNA;Variant;variant of unknown significance;Ventricular Arrhythmia

PROJECT_TITLE: Calcium Release Channel Deficiency Syndrome

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Cardiovascular;Genetics;Heart Disease;Human Genome;Radiation Oncology;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Radiation therapy (RT) is a pillar of cancer therapy, yet certain group of cancer patients undergoing RT suffer from serious cardiovascular disease. Our research team will study why certain patients suffer from RT-induced heart disease (RIHD) using cardiovascular cells made from patient samples and animal model of RIHD. Ultimately, we seek to develop safe and efficacious drugs to cure RIHD that can improve the efficacy of radiotherapy treatment without concomitant cardiovascular side effects.

PI_NAMEs: MERCOLA, MARK ;WU, JOSEPH C. (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: 3-Dimensional;A549;Adopted;Affect;Animal Model;Biology;Blood Vessels;Breast Cancer Cell;Calcium;Cancer cell line;Cancer Patient;Cancer Survivor;cancer therapy;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiotoxicity;Cardiovascular Diseases;Cardiovascular system;Cell Death;Cell Death Induction;Cell Line;Cells;Censuses;Chromosome Mapping;Collaborations;Complex;Consumption;Diagnosis;disease model;Disease Progression;Disease susceptibility;Dose;drug efficacy;Drug Screening;Endothelial Cells;Endothelium;Engineering;epigenome;FDA approved;Fibroblasts;Genes;Genetic;Genetic Annotation;Genetic Polymorphism;Genetic Population Study;genetic risk factor;genetic variant;Genetic Variation;Grant;Heart;Heart Diseases;heart function;heart preservation;Heterogeneity;high throughput analysis;high throughput screening;Homeostasis;human induced pluripotent stem cells;improved;improved outcome;induced pluripotent stem cell;induced pluripotent stem cell technology;interest;irradiation;Kinetics;lead candidate;Link;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Maps;materials science;medication safety;Mesenchymal;Modeling;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;multiple omics;Mus;Myofibroblast;novel;Organ;p53 Signaling Pathway;patient derived induced pluripotent stem cells;Patients;Pharmaceutical Preparations;Phenotype;Population Genetics;Predisposition;Proteome;Proteomics;Quantitative Trait Loci;Radiation;radiation mitigation;Radiation Oncology;Radiation Protection;radiation risk;Radiation therapy;Radiobiology;Reporter;Research;response;Risk Factors;Roentgen Rays;Sampling;screening;Serum;side effect;Single Nucleotide Polymorphism;single-cell RNA sequencing;Techniques;Technology;Testing;Therapeutic;Therapeutic Index;Time;Tissue Model;Tissues;TP53 gene;transcriptome;Treatment-Related Cancer;Vascularization;x-ray irradiation;Xenograft procedure

PROJECT_TITLE: Modeling Susceptibility to Radiation Therapy-induced Cardiotoxicity Using Cell Village iPSCs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-D (02)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Contraception/Reproduction;Endocrine Disruptors;Infertility;Prevention;Women's Health Research

ORG_CITY: TUCSON

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE This proposal supports the creation of a virtual consortium that will use translational and transdisciplinary disciplinary approaches to provide the research community with an innovative computationally-based method to predict adverse effects of phthalates on ovarian function in women. This work will benefit human reproductive health by enhancing the screening of chemicals that could harm ovarian function in women. The transdisciplinary and translational environment created by this consortium will also provide unique cross- disciplinary training opportunities to trainees in the five institutions involved.

PI_NAMEs: CRAIG, ZELIEANN RIVERA (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: 3-Dimensional;Adverse effects;American;Animal Model;Animals;Autocrine Communication;Behavior;Biological;Biological Markers;Biology;case-based;Cells;Chemicals;Communication;Communities;Complex;computational toxicology;Computer Models;computerized tools;Confidence Intervals;cost;Coupling;Data;Development;Diameter;egg;Endocrine;Environment;Environmental Exposure;Ethics;Evaluation;Fertility;folliculogenesis;Generations;Goals;Gonadotropins;Hazard Identification;Health;Health Status;Hormones;Human;in silico;In Vitro;in vivo;in vivo Model;Infertility;infertility treatment;innovation;Institution;Laboratories;Laboratory Animal Models;Lead;Macaca;Macaca mulatta;Measures;Methods;Modeling;Mus;nonhuman primate;Organ;Output;Ovarian;Ovarian Follicle;Ovary;ovotoxicity;Ovulation;Paracrine Communication;Pathway interactions;phthalates;Physiological;predictive marker;Predictive Value;Predisposition;pregnant;Process;Production;proliferative phase Menstrual cycle;reproductive;Reproductive Health;reproductive outcome;reproductive toxicity;Research;Research Personnel;response;Risk;Rodent;screening;Signal Transduction;Source;Steroid biosynthesis;Stochastic Processes;Subfecundity;success;synergism;Testing;Time;tool;Toxic effect;Toxic Environmental Substances;toxicant;Toxicant exposure;Toxicity Tests;Toxicokinetics;Toxicology;training opportunity;translational model;translational study;virtual;Woman;women's outcomes;Work;zygote

PROJECT_TITLE: In Vitro to In Vivo Extrapolation of Toxicant Effects on Ovarian Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 VSM-S (VC)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: GREAT FALLS

ORG_NAME: MC LAUGHLIN RESEARCH INSTITUTE

ORG_STATE: MT

PHR: Overall Plan: Narrative The goal of this application is to establish the Center for Integrated Biomedical and Rural Health Research (CIB- RHR), a Center of Biomedical Research Excellence (CoBRE), that will enhance research infrastructure in a unique geographical, socio-cultural and economic region of the Rocky Mountain front and adjacent plains. The application is significant as it serves the two primary purposes of increasing the cohort of NIH funded investigators and of advancing our understanding of common health conditions of special concern and/or prevalence in a rural environment. The application is innovative in that the Center will provide unprecedented opportunities for talent recruitment and innovation in a rural underserved region of the United States, will establish the physical and intellectual presence required to increase trust in biomedical research in rural communities, and will serve as a potential model for other rural communities.

PI_NAMEs: REIJO PERA, RENEE A (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Acceleration;Address;Admission activity;Age related macular degeneration;alpha synuclein;Alzheimer's Disease;Animal Model;Apoptosis;Area;Basic Science;behavioral health;Big Data;Bioinformatics;Biomedical Research;career;career development;Centers of Research Excellence;Chronic Wasting Disease;Clinical;clinical application;Clinical Research;Clinical Trials;cohort;Collaborations;college;Communities;Comprehensive Health Care;Core Facility;County;Development;Diagnosis;Disease;Economics;Eligibility Determination;Ensure;Environment;Equipment;Equity;Evaluation;exosome;experience;Faculty;Faculty Recruitment;Funding;Future;Genes;Genotype;Geographic Locations;Geography;Goals;Grant;Health;health care availability;Health Care Sector;Health Personnel;healthcare community;Healthcare Systems;Human;Idiopathic Parkinson Disease;In Situ;Individual;individualized medicine;innovation;Interdisciplinary Study;Investments;Joints;Laboratories;Leadership;Magnetic Resonance Imaging;matriculation;Medical;medical schools;Medical Students;meetings;member;Mentors;Mentorship;Modeling;Montana;mouse model;multidisciplinary;Nervous System Disorder;neutrophil;novel diagnostics;novel therapeutics;organizational structure;Osteopathic Medicine;outreach;outreach services;Pathogenesis;Phase;Phenotype;Physicians;Pilot Projects;Positioning Attribute;pre-clinical;Prevalence;Proteins;Provider;public trust;recruit;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Resources;Rural;rural area;Rural Community;rural environment;Rural Health;rural underserved;Science;senior faculty;Series;Services;social culture;Students;success;superoxide dismutase 1;System;Talents;Training;training opportunity;Training Programs;Translational Research;translational study;Translations;tribal Nation;Trust;Underrepresented Populations;underserved area;United States;United States National Institutes of Health;Universities;Women's Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (C1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Accounting;Address;Advertisements;Animals;Area;Award;base;Biomedical Research;Blackfeet;Budgets;career development;Centers of Research Excellence;Communities;Comprehensive Health Care;Contracts;cost;Development;Dreams;Education;Educational process of instructing;Educational workshop;Elderly;Employee;Ensure;Equipment;Evaluation;Expenditure;experience;Faculty;Faculty Recruitment;falls;Female;Fostering;Funding;Funding Opportunities;Future;Genes;Goals;Grant;Grant Review;Growth;Health;Healthcare Systems;Home;Human;Human Resources;Individual;Industry;Infrastructure;innovation;Institution;Interview;Investments;Journals;Leadership;Location;Manuscripts;Marketing;Mediation;Medical Education;Medical Research;meetings;member;Mentors;Mentorship;Mining;Mission;Modeling;Montana;mouse model;Occupations;outreach;Ownership;payment;Persons;Phase;Physicians;Pilot Projects;Process;programs;recruit;Reporting;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Resources;Rural Community;Rural Health;rural underserved;Safety;Schedule;Science;Scientist;Services;success;symposium;Talents;timeline;tool;Training;translational genetics;Trust;underserved area;United States;United States National Institutes of Health;Visit;Vocational Guidance;Water;women faculty;Writing;young man;young woman

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Neurosciences;Rural Health;Social Determinants of Health

PI_NAMEs: GUNN, TERESA M (contact)

PROJECT_TERMS: Affect;Aggressive behavior;Animal Experiments;animal resource;Animals;Anxiety;Area;Astrocytes;balance testing;Basic Science;Behavior;behavioral study;Biological Assay;Biomedical Research;Biopsy;Blood;Breeding;Cardiac Myocytes;Caring;Cell Culture Techniques;Cell Line;Cells;Centers of Research Excellence;Coculture Techniques;Cognition;cohort;Collection;Consultations;CRISPR/Cas technology;Cryopreservation;Data;Data Analyses;depressive symptoms;design;Development;Dideoxy Chain Termination DNA Sequencing;Disease;Dissection;DNA;Dose;Ear;Embryo;Employment Opportunities;Ensure;Environment;Equipment;Experimental Designs;experimental study;Faculty;Fee-for-Service Plans;Fibroblasts;Freezing;Funding;Future;Gait;Gel;Genes;Genetic Models;genetic pedigree;Genetic study;Genotype;Goals;Health;Hearing;Histology;IACUC;induced pluripotent stem cell;Infrastructure;Injections;innovation;Institution;Intervention;laboratory experience;Laboratory Personnel;Laboratory Research;Magnetic Resonance Imaging;Maintenance;Mediating;Memory;Mentors;Modeling;Montana;Motor;mouse genetics;mouse model;Mus;neurobehavior;Neurons;Neurosphere;novel;Operative Surgical Procedures;Oral;Paraffin Embedding;Phenotype;programs;Protocols documentation;Readiness;recruit;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Resources;Rural Health;Sampling;Scientist;Services;skills;Source;Stress;success;supportive environment;Sweden;Tail;Techniques;Testing;Tissue Harvesting;Training;Transgenic Organisms;Translational Research;translational study;underserved area;United States National Institutes of Health;Vision

PROJECT_TITLE: Gene Editing and Mouse Models Assessment (GEMMA) Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Rural Health;Social Determinants of Health

PI_NAMEs: HENSLEY-MCBAIN, TIFFANY  (contact)

PROJECT_TERMS: Age;Age Years;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease risk;Amyloid beta-Protein;Animals;anti-microbial peptide;apolipoprotein E-4;Apoptosis;Astrocytes;BCL2 gene;behavior test;Brain;brain parenchyma;Brain Pathology;CASP3 gene;Cell Death;Cells;Centers of Research Excellence;Cerebrovascular system;Chronic;Circulation;Cognitive;Data;Disease;Disease Progression;Equilibrium;experimental study;extracellular;Extracellular Matrix;familial Alzheimer disease;Foundations;Future;Genes;Genotype;Goals;Health;Histologic;Host Defense;Hour;Human;immune activation;Impaired cognition;improved;in vivo;Individual;Infection;Inflammation;Inflammatory;innovation;Invaded;Laboratories;Late Onset Alzheimer Disease;Leukocytes;life span;LytA enzyme;Macrophage;MAP Kinase Gene;Mediating;Memory Loss;Mentorship;Microglia;Modeling;mouse model;Mus;Mutation;Myelin;Necrosis;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuroinflammation;neutrophil;Neutrophil Activation;Neutrophil Infiltration;NF-kappa B;pathogen;Pathogenesis;Pathologic;Pathologist;Pathway interactions;Peripheral;Persons;Physiological;Plasma;Population;promoter;Protein Array;Publishing;Reactive Oxygen Species;repaired;Research;Resolution;response;Rural Health;Sampling;Senile Plaques;Signal Transduction;Stimulus;systemic inflammatory response;therapeutic target;tissue repair;Tissues;translational impact;United States;Work

PROJECT_TITLE: Investigating Neutrophil Apoptosis as a Therapeutic Target in Alzheimer's Disease