NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: OAKLAND

ORG_NAME: PUBLIC HEALTH INSTITUTE

PHR: PEP-CTN Project Narrative: The Pediatric Early Phase Clinical Trials Network (PEP-CTN) is a consortium whose mission is to identify and develop effective new agents for children and adolescents with cancer, through rational and efficient clinical and laboratory research. PEP-CTN clinical trials will incorporate correlative genomics, biology, pharmacology, and imaging studies to help further the understanding of the action of new agents introduced into the treatment of children with cancer. Ultimately, PEP-CTN aims to develop targeted pediatric cancer therapies which are more effective and less toxic. Project Narrative Page 22

PI_NAMEs: WEIGEL, BRENDA J. (contact)

PROGRAM_OFFICER_NAME: SMITH, MALCOLM M

PROJECT_TERMS: Adolescent;Adult;Adverse event;anti-cancer therapeutic;Australia;Biological;Biological Models;Biology;Canada;cancer therapy;Characteristics;Child;Childhood;Clinical Research;Clinical Trials;Clinical Trials Network;cohort;Cohort Studies;Common Terminology Criteria for Adverse Events;Complex;Cytotoxic agent;Data;Databases;Development;DNA Sequence Alteration;Drug Kinetics;early phase clinical trial;early phase trial;Enrollment;Ensure;exome sequencing;Genes;Genomics;imaging modality;imaging study;Informatics;Infrastructure;Institution;International;Laboratory Research;Laboratory Study;Malignant Childhood Neoplasm;Malignant Neoplasms;member;Mission;Modeling;Molecular Profiling;Molecular Target;New Agents;novel;novel anticancer drug;Parents;Pathway interactions;Patient Outcomes Assessments;Patients;Pediatric Oncology;Pediatric Oncology Group;Peer Review;Pharmacogenetics;pharmacologic;Pharmacology Study;Phase;phase 3 testing;Pilot Projects;pre-clinical;Process;Proxy;Reporting;Resources;response;Signal Transduction;Site;Symptoms;System;targeted agent;targeted treatment;Therapeutic;Toxic effect;transcriptome sequencing;tumor;tumor DNA

PROJECT_TITLE: Children's Oncology Group Pediatric Early Phase Clinical Trial Network


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Neurosciences;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Project Narrative – MAE-WEST SCORE Overall Women compared to men experience an excess of burden of age-related diseases of the heart, brain, and kidney for reasons that remain unclear. Growing evidence points to the potential importance of chronic inflammation and small blood vessel dysfunction as key determinants of the sex differences seen in age-related disease outcomes. Therefore, we will establish a Specialized Center of Research Excellence focused on comprehensively investigating sex differences in the molecular drivers of chronic inflammation, microvascular aging, and end-organ disease. !

PI_NAMEs: BAIREY MERZ, CATHLEEN NOEL;CHENG, SUSAN  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Address;Advocacy;Age;age difference;Age disparity;age effect;age related;age related changes;age-related disease;Aging;Alzheimer's disease related dementia;Awareness;Basic Science;Bioinformatics;Biological;Blood Vessels;Body System;Brain;Brain Diseases;burden of illness;Cardiology;Cardiovascular system;career;Cell Physiology;Centers of Research Excellence;Chronic;Chronic Disease;Chronic Kidney Failure;clinical development;clinical phenotype;Clinical Sciences;cohort;Communities;Data;Development;Disease;Disease Outcome;Education;effective intervention;EFRAC;Eicosanoids;Endothelial Cells;Enrollment;Epidemiologist;Evaluation;Exhibits;experience;Experimental Models;FDA approved;Female;forward genetics;Foundations;frailty;functional decline;Functional disorder;Funding;Geriatrics;Goals;Health;healthspan;Heart;Heart Diseases;Heart failure;heart function;Human;improved;In Vitro;Incidence;Individual;Inflammation;Inflammatory;Infrastructure;innovation;insight;Kidney;Kidney Diseases;Leadership;Life Cycle Stages;life span;Lipids;Longevity;male;Mass Spectrum Analysis;Measures;Mediating;Mediator;Medical;men;Mentors;Mentorship;microvascular aging;Microvascular Dysfunction;Molecular;multidisciplinary;Nature;Nephrology;Neurocognitive;next generation;novel therapeutic intervention;operation;Organ;Organ Model;Organism;Outcome;Pathway interactions;Pharmaceutical Preparations;Phenotype;Physiology;Plasma;Population Sciences;Positioning Attribute;preservation;Process;programs;prospective;rate of aging;receptor;Receptor Activation;Renal function;Request for Applications;Research;Research Personnel;Research Project Grants;Resources;response;Role;Sampling;Science;Scientific Advances and Accomplishments;Scientist;Secure;sex;Sex Differences;sex disparity;sexual dimorphism;Signal Transduction;Specialized Center;stressor;Structure;Syndrome;System;systemic inflammatory response;Therapeutic;Training;trait;translational scientist;Variant;Whole Organism;Woman;women versus men;Women's cohort;Women's Health;Work

PROJECT_TITLE: The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative This proposal seeks funding for the seventh cycle of our training program in Pathophysiology and Rehabilitation of Neural Dysfunction (PRND). The specific objectives are to train prospective researchers from engineering and the basic sciences who understand the spectrum of problems confronting people with neurologic disabilities, and who possess the clinical, scientific, and quantitative skills to alleviate the burden on this growing population.

PI_NAMEs: HARGROVE, LEVI JOHN (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Functional disorder;Neuronal Dysfunction;Rehabilitation therapy


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Dietary Supplements;Eye Disease and Disorders of Vision;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: BIRMINGHAM

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Optic nerve hypoplasia (ONH) is one of the most common congenital disorders of the optic disc and an increasingly prevalent cause of childhood blindness. Not much is known about this pervasive disease with very few animal models available. In our current proposal we describe a translational project on this disorder, one which is also likely to delineate a common pathway linking association of ONH with nutritional deprivation, infantile cholestasis, maternal diabetes, fetal alcohol syndrome, mitochondrial cytopathies, and peroxisomal disorders.

PI_NAMEs: MUKHERJEE, KONARK  (contact)

PROGRAM_OFFICER_NAME: HENLE, STEVEN JOHN

PROJECT_TERMS: 3-Dimensional;Acids;Alcohol abuse;alcohol exposure;Alleles;Animal Model;Arachidonic Acids;Astrocytes;astrogliosis;awake;Axon;axonopathy;Behavioral Assay;Biochemical;Blindness;Bolus Infusion;Brain;Central Nervous System;Childhood;Cholestasis;Clinic;Clinical;Congenital Disorders;Contrast Sensitivity;Data;Defect;Developed Countries;Development;Diabetes Mellitus;Diameter;Diet;dietary;Disease;Docosahexaenoic Acids;Electrophysiology (science);embryonic alcohol exposure;Essential Fatty Acids;Etiology;experimental study;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Female;Fetal Alcohol Syndrome;Functional disorder;Genes;Heterozygote;Histopathology;Human;in utero;in vivo;Incidence;infancy;innovation;Knockout Mice;Knowledge;Label;Lactation;Life;Life Style;Link;Linoleic Acids;lipid metabolism;Lipids;liquid chromatography mass spectrometry;Maintenance;Maternal Age;maternal diabetes;Measurement;Measures;Mediating;Metabolic;Metabolism;Milk;Mitochondria;mitochondrial metabolism;Mitochondrial Proteins;Modeling;Molecular;Morphology;mother nutrition;Mothers;mouse model;Mus;Mutant Strains Mice;Mutation;Nature;Neonatal;neonate;neurodevelopment;Neuroglia;novel;nutrient deprivation;offspring;Omega-6 Fatty Acids;Optic Disk Disorder;Optic Nerve;optic nerve disorder;Oral;oxidative damage;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Performance;Peroxisomal Disorders;Phospholipids;Pituitary Gland;Play;postnatal;pregnant;prenatal;Production;protein expression;protein function;Proteins;Publishing;Reactive Oxygen Species;response;Retina;Retinal Ganglion Cells;Role;Supplementation;Techniques;Testing;Thinness;Third Pregnancy Trimester;tool;Ultrastructural Pathology;uptake;Vision;Visual;visual excitation;Visual System

PROJECT_TITLE: Role of fatty acid metabolism in optic nerve hypoplasia

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Biomedical scientists use descriptions of biomedical concepts (and of the relationships among concepts) known as ontologies to standardize how researchers and clinicians talk about biomedical phenomena. BioPortal is a computer system that integrates more than 1000 biomedical ontologies, making it easy for scientists and clinicians to use the resulting knowledge to describe their data, to access information more reliably, to build other knowledge resources in standardized ways, and to bring biomedical knowledge both to the laboratory and to the point of care. The infrastructure that BioPortal uses to store its ontology content has reached the end of its expected lifespan, thus this supplement will allow us to replace the storage unit to extend the durability of the entire BioPortal resource for many more years.

PI_NAMEs: MUSEN, MARK A (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Access to Information;biomedical ontology;biomedical scientist;Communities;Computer Systems;Data;Development;electronic data capture system;Ensure;Equipment;equipment acquisition;Failure;Fright;Goals;Information Resources;Infrastructure;Knowledge;knowledge base;knowledge of results;knowledgebase;Laboratories;life span;Maintenance;Metadata;Modernization;Ontology;parent grant;parent project;Performance;point of care;Research Personnel;Resources;Scientist;Standardization;System;Terminology;United States National Institutes of Health;Work

PROJECT_TITLE: BioPortal: An Expansive Knowledgebase of Biomedical Entities and Relations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Depression;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Rehabilitation

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Adolescents and young adults living with HIV (YLH) experience high rates of non-retention in care, and it is important to identify key factors influencing non-retention. The proposed F31 project leverages data from an ongoing cluster randomized trial to identify demographic, social, behavioral, and clinical cofactors of non- retention among YLH (10-24 years), determine trajectories of depression and adherence self-efficacy during 12- month longitudinal follow-up, as well as examine caregivers’ experiences navigating HIV adherence and retention support for YLH. Findings from this study will inform future interventions tailored to YLH and their caregivers, identify age-disaggregated cofactors of non-retention, and provide opportunities for the F31 candidate to gain new methods and content-area expertise and advance as an independent investigator.

PI_NAMEs: HICKS, SARAH  (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: Adherence;Adolescent;Adolescent and Young Adult;Age;age group;age related;age stratification;aged;antiretroviral therapy;Anxiety;anxiety symptoms;Behavior;Behavioral;caregiver depression;Caregiver support;Caregivers;Caring;Characteristics;Clinic;Clinical;Cluster randomized trial;cofactor;Communities;Counseling;Cox Proportional Hazards Models;Data;Data Analyses;Decision Making;depressive symptoms;Drops;early adolescence;Emotional;Environment;Epidemiology;experience;Face;Failure;Family member;Feeling;Female;Focus Groups;follow-up;Future;Gender;Goals;hazard;Health;high risk;HIV;HIV Infections;HIV-infected adolescents;human old age (65+);improved;Individual;Intervention;Kenya;Link;Lived experience;male;Mental Depression;Mental Health;Methods;Modeling;Motivation;Outcome;Parents;Participant;patient retention;Pattern;Perception;Persons;Population;pre-doctoral;Probability;Regimen;Reporting;Research;Research Personnel;Resources;Role;Schedule;Self Efficacy;Site;social;social stigma;Social support;Source;Statistical Methods;Subgroup;substance use;therapy adherence;Training;transmission process;treatment arm;Viral;Viral Load result;Visit;young adult;Youth

PROJECT_TITLE: Effects of caregiver interactions, youth characteristics, and counseling on retention in care among youth living with HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17B-M (20)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Congenital Structural Anomalies;Digestive Diseases;Genetics;Human Genome;Kidney Disease;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Polycystic Kidney Disease;Rare Diseases

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Biliary atresia the principal reason for liver transplantation in children, yet is without known causes or effective medical therapies. The research in this proposal aims to fill these large knowledge gaps by performing studies in a newly-created mouse model of biliary atresia. This novel mouse model is based upon recent genetic studies indicating that mutations in the gene PKD1L1 may be a cause of biliary atresia.

PI_NAMEs: KARPEN, SAUL J. (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: 3-Dimensional;Abdomen;Address;Adult;Age;Agonist;Antibodies;Apical;Bile Acids;bile duct;Bile fluid;Biliary;Biliary Atresia;biliary tract;Biliary Tract Diseases;Biology;Cardiac;Cell Physiology;Cells;Chemistry;Child;Child Support;cholangiocyte;Cholestasis;Cilia;Clinical;Comparative Study;Crossbreeding;Data;Defect;Development;Disease;Distal;Duct (organ) structure;Dysmorphology;efficacy evaluation;Etiology;Evaluation;exome;exome sequencing;experimental study;Exposure to;Extrahepatic Bile Ducts;Functional disorder;Generations;Genes;Genetic Models;Genetic Predisposition to Disease;Genetic study;Handedness;Histologic;Histology;Human;Human Genetics;hydrophilicity;Impairment;In Vitro;Individual;inhibitor;insight;intrahepatic;Knowledge;Ligation;Link;Liver;liver development;liver transplantation;malformation;Medical;Membrane;Membrane Proteins;Modeling;Molecular;mouse model;Mus;Mutation;N-terminal;National Institute of Diabetes and Digestive and Kidney Diseases;neonate;novel;novel strategies;Obstruction;Organ;Organoids;Oryctolagus cuniculus;Participant;Pathogenesis;Pathway interactions;Polycystic Kidney Diseases;postnatal;pre-clinical;prenatal;pressure;Proteomics;Research;response;RNA;Role;Serum;Signal Transduction;Subcellular structure;Surface;Syndrome;Testing;Therapeutic;Therapeutic Intervention;three-dimensional modeling;Time;transcriptomics;Transgenic Organisms;Treatment Efficacy;Variant

PROJECT_TITLE: Modeling genetic contributions to biliary atresia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-Y(05)]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PI_NAMEs: PATTERSON, THOMAS  (contact)

PROJECT_TERMS: Contracts;Development;Evaluation;fungus;infectious disease model;mouse model;Mycoses;therapeutic development;therapeutic evaluation

PROJECT_TITLE: Task A65: Therapeutics Testing in Murine Models of Fungal Infections


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: MCLEAN

PI_NAMEs: FERNANDEZ, ANNA  (contact)

PROJECT_TITLE: SUPPORT SERVICES FOR SEER PROGRAM_CCDI funding


PROJECT_TERMS: Clinical;Image;SEER Program;Services

PROJECT_TITLE: SUPPORT SERVICES FOR SEER PROGRAM


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: Lowell

ORG_NAME: VERSATOPE THERAPEUTICS, INC.

ORG_STATE: MA

PI_NAMEs: LOCHER, CHRISTOPHER  (contact)

PROJECT_TERMS: Advanced Development;Animal Model;Clinical;Communicable Diseases;Contracts;Disease Outbreaks;efficacy evaluation;efficacy testing;Emerging Communicable Diseases;Formulation;immunogenicity;Individual;influenza virus vaccine;manufacture;response;Safety;stability testing;Toxicology;universal influenza vaccine;universal vaccine;vaccine development;Vaccines

PROJECT_TITLE: Advanced Development of Universal Vaccines for Universal Influenza


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: EAST WINDSOR

ORG_NAME: AURO VACCINES LLC

ORG_STATE: NJ

PI_NAMEs: ELDRIDGE, JOHN  (contact)

PROJECT_TERMS: Advanced Development;Contracts;Cyclic GMP;Development;Ebola virus;Filovirus;Freeze Drying;Lassa Fever;manufacture;Marburgvirus;pathogen;Preparation;research clinical testing;vaccine candidate;vaccine development;vaccine formulation;Vaccines;Virus

PROJECT_TITLE: Advanced Development of Vaccines for Filoviruses


ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: NARRATIVE This project will have a significant impact on the fundamental understanding of bacterial physiology by determining why ribosome rescue pathways are essential for bacteria, providing the first structural and biochemical pictures of ribosomal interactions required for ribosome rescue, and providing biochemical and structural information that will allow rational optimization of the activity of ribosome rescue inhibitors. These studies will enable development of ribosome rescue inhibitors as new antibiotics. Therefore, this work will have a large and direct impact on improving human health.

PI_NAMEs: DUNHAM, CHRISTINE M;KEILER, KENNETH C (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Affect;Antibiotics;Bacteria;Bacterial Genome;Bacterial Physiology;Binding;Biochemical;Biological;Biology;Caulobacter crescentus;Cells;Chemicals;Data;Development;experimental study;Foundations;Funding;Genes;Genetic;Goals;Grant;Growth;Health;Homologous Gene;Human;Hydrolysis;improved;inhibitor;innovation;insight;Knowledge;Messenger RNA;Molecular;Molecular Target;mRNA Transcript Degradation;Multi-Drug Resistance;Mutation Analysis;Outcome;Oxidative Stress;pathogenic bacteria;Pathogenicity;Pathway interactions;peptidyl-tRNA;pharmacologic;Phylogenetic Analysis;Physiological;Physiology;polypeptide;Process;Property;Publishing;recruit;Research;Ribosomal Interaction;Ribosomal Proteins;Ribosomes;RNA;Role;small molecule;small molecule inhibitor;SmpB protein;Solid;Structure;System;Terminator Codon;Testing;tmRNA;tool;Translating;translation factor;Translations;Virulence;Work

PROJECT_TITLE: Physiology of ribosome rescue in bacteria

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Neurosciences;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Human noise-induced hearing loss (NIHL) usually occurs due to accumulated damage across repeated exposures, in contrast to studies in animal models where hearing loss is typically induced by single high-level noise exposures. By combining chronic noise exposures (modeled after human occupational noise exposure) in macaques with anatomical, behavioral, and physiological studies, we will document the sequential progression of hearing difficulty and hearing loss with cochlear pathology: progressive damage is expected to be associated with progressive deficit. The studies are designed to elucidate the sequence of hearing changes and the dosage of noise associated with those changes, and to identify clinically adaptable tests and measures that can be used as early warning signs of hearing dysfunction.

PI_NAMEs: COX, BRANDON C.;LE PRELL, COLLEEN G.;RAMACHANDRAN, RAMNARAYAN  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Adopted;Adult;Affect;Anatomy;Animal Model;Animals;Audiology;Auditory;Auditory Brainstem Responses;auditory processing;Behavioral;Behavioral Assay;Binaural;Biological Markers;Cell Death;Cell Physiology;Characteristics;Chronic;Clinical;clinically significant;Cochlea;Complex;Data;design;detection assay;Development;Disease;dosage;Dose;ear muscle;Early Diagnosis;Electrophysiology (science);Environment;Euthanasia;experience;Exposure to;Female;Frequencies;Hair Cells;Hearing;hearing impairment;Hearing Tests;histological studies;Histology;Histopathology;Hour;Human;in vivo;Individual;Injury;Inner Hair Cells;insight;Laboratories;Loudness;Macaca;male;Masks;Measurable;Measures;middle ear;Modeling;Monitor;Monkeys;mouse model;Natural regeneration;Noise;noise exposure;Noise-Induced Hearing Loss;nonhuman primate;normal hearing;Occupational;Occupational Exposure;Occupational injury;Occupational Noise;otoacoustic emission;Outcome;Outer Hair Cells;Pathology;Pattern;Performance;Phenotype;Phylogenetic Analysis;Physiological;Predisposition;prevent hearing loss;Prevention program;Primates;Protocols documentation;Psychophysics;Recovery;Recreation;Reflex action;Reporting;Research Design;response;ribbon synapse;Rodent;Rodent Model;signal processing;sound;Study models;Synapses;Temporary Threshold Shift;Testing;Time;timeline;Training;Work

PROJECT_TITLE: Consequences of chronic noise exposure in nonhuman primates


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hematology;Neurosciences;Stroke

ORG_CITY: CINCINNATI

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: There is a need to discover new treatments for ischemic stroke because, for most patients, we cannot currently prevent long-term disability and its associated suffering and expense. Experimental stroke research shows that inactivation of alpha2-antiplasmin (a2AP-I) profoundly reduces brain injury, hemorrhage, disability and death, in a longer time window, than the best available medical therapy. Following a successful Phase I trial of an a2AP-I called TS23, this Phase II NIH StrokeNet trial will investigate whether a particular dose is safe and potentially effective in patients who present late after ischemic stroke, for whom there is no effective therapy.

PI_NAMEs: ELM, JORDAN J.;KHATRI, POOJA  (contact);MISTRY, EVA ;REED, GUY L

PROGRAM_OFFICER_NAME: AFZAL, MARIAM MASHEEB

PROJECT_TERMS: Acute;Advanced Development;Advisory Committees;Alteplase;Antibody Therapy;Antiplasmin;Apoptosis;artery occlusion;Basic Science;Biometry;Blinded;Blood - brain barrier anatomy;Blood coagulation;Blood flow;Blood Vessels;Brain;Brain hemorrhage;Brain Infarction;Brain Injuries;Brain Ischemia;brain tissue;Cardiology;Caring;Cessation of life;Clinical;Clinical Treatment;Clinical Trials;cost;Cyclic GMP;Data;Development;disability;disabled;Dose;effective therapy;efficacious treatment;Eligibility Determination;endovascular thrombectomy;Failure;Fibrin fragment D;Fibrinolysis;Funding;Future;Gelatinase B;healthy volunteer;Hemorrhage;Hour;Human;Impairment;improved;Infarction;Inflammation;innovation;Intracranial Hemorrhages;Ischemia;Ischemic Stroke;Laboratories;Left;Link;Long term disability;manufacture;Measures;Mediating;Medical;Modeling;Molecular;Monoclonal Antibodies;mortality;National Institute of Neurological Disorders and Stroke;Neurologic;Neurological disability;Neurological outcome;Neurology;neurotoxic;neurotoxicity;neutrophil;Neutrophil Infiltration;Outcome Measure;Patients;perfusion imaging;Persons;pharmacologic;Phase;phase I trial;phase II trial;Placebo Control;Placebos;Plasminogen Activator;Play;post stroke;pre-clinical;Pre-Clinical Model;prevent;primary outcome;Probability;Process;Property;protective effect;Randomized;Recombinants;Relative Risks;Reperfusion Therapy;Reproducibility;Research;Research Support;Risk;Role;Safety;Site;stability testing;standard of care;Stroke;stroke model;stroke outcome;stroke patient;stroke therapy;StrokeNet trials;study population;Swelling;Symptoms;Tenecteplase;Testing;Therapeutic;thromboembolic stroke;Thrombosis;Thrombus;Time;Tissues;tool;Toxic effect;Toxicology;translational medicine;Treatment Failure;treatment response;trial design;United States National Institutes of Health

PROJECT_TITLE: Strategy for Improving Stroke Treatment Response (SISTER) Trial


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Pain Research;Patient Safety;Pediatric;Prevention;Screening and Brief Intervention for Substance Misuse;Substance Misuse;Substance Misuse Prevention

ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Substance use among adolescents (ADOL) is prevalent, yet grossly undertreated. Wisdom tooth extraction is a common, acutely painful procedure for ADOL that represents an opportune time to identify ADOL substance use and engage ADOL in brief intervention due to shared risk factors between SU and pain, the potential for exposure to prescription opioids for pain management, and because substance use is associated with increased risk for post-operative complications. This study aims to adapt and evaluate a novel, scalable pre- surgical brief intervention for ADOL with substance use undergoing oral surgery (i.e. wisdom tooth extraction) that dually targets substance use and pain coping.

PI_NAMEs: PIELECH, MELISSA  (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: 15 year old;Academy;acceptability and feasibility;Accident and Emergency department;Acute;Acute Pain;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Age;Age of Onset;Alcohols;American;Attenuated;Behavior;Behavior Therapy;brief intervention;career development;Child Psychology;Childhood;clinical encounter;Clinical Trials;comparison control;coping;craving;Data Analyses;Dental;Dental Care;Dental Clinics;Dentists;design;Development;Ecological momentary assessment;Education;Enrollment;Ensure;Evaluation;Event;evidence base;Evidence based intervention;experience;Exposure to;Feedback;Focus Groups;follow up assessment;Frequencies;Funding;Future;Health;high risk;Impairment;implementation context;improved;improved outcome;Influentials;informant;innovation;integrated care;interdisciplinary collaboration;Intervention;intervention refinement;Interview;Knowledge;Leadership;Life;marijuana use;Measures;Medical;Mentors;Mentorship;Methods;non-opioid analgesic;novel;Operative Surgical Procedures;Opioid;opioid misuse;opioid use;Oral Surgeon;Oral Surgical Procedures;Outcome;Pain;Pain intensity;Pain management;Parents;Patient Self-Report;Patients;Pediatrics;Perioperative;Persons;Phase;Postoperative Complications;Postoperative Pain;Postoperative Period;Practice Management;prescription opioid;primary care setting;Procedures;Productivity;Provider;psychosocial;Public Health;Randomized, Controlled Trials;Recommendation;recruit;reduced substance use;Research;research and development;Rhode Island;Risk;Risk Factors;risk minimization;risk mitigation;risk sharing;satisfaction;screening;screening and brief intervention;Screening procedure;screening, brief intervention, referral, and treatment;skills;Structure;Substance Addiction;substance use;Substance Use Disorder;substance use treatment;substance user;Testing;therapy development;Time;Tooth Extraction;Training;wisdom tooth;Work;young adult;Youth

PROJECT_TITLE: Adapting and evaluating an integrated intervention for adolescent substance use and pain during oral surgery

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Contraception/Reproduction;Endocrine Disruptors;Estrogen;Infertility;Women's Health Research

ORG_CITY: NEWARK

ORG_DEPT: CHEMISTRY

ORG_NAME: NEW JERSEY INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Exposure to endocrine disrupting chemicals such as phthalates contributes to increased rates of human infertility and reproductive disorders worldwide. The proposed research will fill a public health need by developing a method to investigate the mechanisms through which endocrine disrupting chemicals such as phthalates act to cause toxicity in the ovary. The results of this project will facilitate the development of safer alternative chemicals and contribute to the identification of new treatments to protect the ovary from environmental chemical exposure.

PI_NAMEs: WARNER, GENOA R (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Acceleration;Affinity;Award;Behavior;Biochemical;Biological;Biology;building materials;career;career development;Cell Culture Techniques;Cell membrane;cell type;Cells;Cessation of life;Chemical Structure;Chemicals;Chemistry;Child;chromatin immunoprecipitation;Complex;consumer product;Culture Media;Data;Development;Development Plans;Dioxins;Disease;DNA-Binding Proteins;Endocrine disruption;Endocrine Disruptors;Environment;environmental chemical exposure;Environmental Health;Enzymes;Equipment;Esters;exposed human population;Exposure to;Family;Female;Female infertility;Gene Expression;General Population;Genes;Genetic Transcription;Genomics;Goals;Hormones;Human;Hydrocarbons;Illinois;Image;imaging modality;In Vitro;Individual;Industrialization;Infertility;innovation;insight;Label;Length;lipophilicity;Mass Spectrum Analysis;Massive Parallel Sequencing;Mediating;Medical;men;Mentors;Mentorship;Metabolism;Methods;Modernization;Molecular;mouse model;Nature;novel;Oocytes;Ovarian;Ovarian aging;Ovarian Follicle;Ovarian Tissue;Ovary;ovotoxicity;personal care products;Phase;phthalates;Phthalic Acids;Plasticizers;Population;Postdoctoral Fellow;Premature Ovarian Failure;Prevalence;Prevention;programs;Property;Proteins;Public Health;receptor;Reproduction;reproductive;Reproductive Biology;reproductive organ;reproductive system disorder;Research;Research Personnel;Research Proposals;Research Training;Sampling;screening;Side;skills;small molecule;Solvents;Structure;Techniques;Technology;Testing;Tissues;Toxic effect;toxicant;Toxicology;Toy;Training;transcription factor;Universities;Urine;Visualization;Woman

PROJECT_TITLE: Mechanisms of Phthalate Toxicity in the Ovary

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Childhood Injury;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Unintentional Childhood Injury

ORG_CITY: MISSISSIPPI STATE

ORG_NAME: MISSISSIPPI STATE UNIVERSITY

ORG_STATE: MS

PHR: Project Narrative Therapeutics being developed for organophosphate (OP) poisoning have not been tested in juvenile animals, but infants and children are certainly likely to be poisoning victims in terrorist attacks or chemical accidents and are likely to be more vulnerable than adults. Therefore, a testing paradigm using juvenile animals is needed to provide useful information on the efficacy and safety of current therapeutics and therapeutics under development. This supplement application proposes to develop such a paradigm in juvenile rats (12 and 21 postnatal days equivalent to 3 and 7 years in humans) by investigating the levels and time frame of two OPs that are acutely toxic, and validating that the standard of care (atropine and an oxime reactivator) are effective therapy.

PI_NAMEs: CHAMBERS, JANICE ELAINE (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Accidents;Acetylcholinesterase;Acute;acute toxicity;Adolescent;Adult;Advanced Development;Age;Animal Model;antagonist;Antidotes;Appearance;Atropine;Attenuated;Behavior;Brain;Cessation of life;chemical accident;Chemicals;Chemistry;Child;Childhood;Cholinesterase Inhibitors;Convulsions;Data;Databases;design;Development;dosage;Dose;effective therapy;efficacy evaluation;Evaluation;experience;FDA approved;Future;Goals;Human;improved;Infant;Insecticides;invention;Investigation;Isoflurophate;juvenile animal;Laboratories;lead candidate;Literature;mass casualty;mature animal;medical countermeasure;methylphosphonate;model organism;Modeling;Muscarinic Acetylcholine Receptor;Natural History;nerve agent;neuropathology;novel;organophosphate poisoning;Organophosphates;Oximes;Paraoxon;Parathion;parent project;Pediatric Research;Penetration;Persons;Poison;Poisoning;postnatal;programs;Rattus;Recurrence;Research;respiratory;Safety;Sarin;Seizures;sex;standard of care;subcutaneous;Terrorism;Testing;Therapeutic;Time;Toxic effect;Treatment Efficacy;Tremor;United States National Institutes of Health;Validation

PROJECT_TITLE: Pediatric model for evaluation of effects of and therapies for high level organophosphate anticholinesterase poisoning.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Immunotherapy;Precision Medicine

ORG_CITY: Aurora

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Non-infectious uveitis causes 10% of blindness in the United States and disproportionately affects working- aged people, making it a significant public health issue. Targeted corticosteroid-sparing immune therapies are only variably effective because the underlying pathogenic mechanisms in ocular inflammation are not well understood. If successful, this research will address this knowledge gap and advance the NEI’s goals by: 1) developing advanced molecular diagnostic tools, 2) better defining heterogeneity within uveitis and 3) identifying the roles of specific immune mediators in individual inflammatory syndromes.

PI_NAMEs: HASSMAN, LYNN M (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Acute;adaptive immune response;Adopted;Adrenal Cortex Hormones;Affect;aging population;Anti-Inflammatory Agents;aqueous;arm;Automobile Driving;Bioinformatics;Biological Markers;Biological Response Modifiers;Blindness;candidate marker;CD8-Positive T-Lymphocytes;Cells;Chronic;Classification;Clinical;cohort;Data;Dendritic Cells;Development;diagnostic tool;Disease;disease classification;disease model;disorder subtype;drug action;experience;Experimental Models;exposed human population;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic Transcription;Genomics;Goals;Heterogeneity;Human;human disease;Immune;Immune Targeting;immunoregulation;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Individual;ineffective therapies;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Investigation;Knowledge;large datasets;Liquid substance;Methodology;Methods;Modeling;Molecular;molecular diagnostics;molecular marker;mouse model;Mus;Myeloid Cells;novel;Ophthalmology;Outcome;Pathogenicity;Patients;peripheral blood;Phenotype;Play;precision medicine;predictive signature;Public Health;Research;Resolution;Role;Sampling;scaffold;Severities;Shapes;side effect;Signal Transduction;single cell analysis;single-cell RNA sequencing;Surrogate Markers;Syndrome;Techniques;Testing;Therapeutic;therapeutic target;Time;Tissue-Specific Gene Expression;tool;Training;Translating;treatment strategy;United States;Uveitis;Validation

PROJECT_TITLE: Resolution of ocular inflammation: the role of type 1 conventional dendritic cells


ADMINISTERING_IC: HG

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE This research project is relevant to public health as it investigates the genomic and social determinants of health within a heterogeneous group of Latinx immigrants living within the United States. By understanding and honing in on the genotypic and environmental factors that cause differential adverse health outcomes within Cuban immigrants and Cuban-Americans, scientists, public health experts, community members, organizers, and policy makers can work collectively to change these conditions for the betterment of current and future immigrant populations and their descendants within the United States. Additionally, this work will also address how environmental factors including the social determinants of health are embodied within historically and currently marginalized groups through the use of epigenomics in conjunction with sociocultural approaches to understanding lived experiences.

PI_NAMEs: HERNANDEZ, MARGARITA  (contact)

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TERMS: Acculturation;Address;Area;Asthma;Biological;Black Populations;cardiovascular health;career;Categories;Cause of Death;Cholesterol;Chronic Kidney Failure;Collection;Communities;Consumption;Country;Cuban;Cuban American;Data;Data Collection;Data Set;Diabetes Mellitus;Discrimination;DNA;Educational Status;End stage renal failure;Enrollment;Environmental Risk Factor;epigenomics;ethnic discrimination;ethnic minority;Ethnic Origin;Ethnic Population;experience;Face;Family;Florida;Future;Generations;Genetic;Genome;genomic data;Genomics;Genotype;Goals;Health;health determinants;health disparity;Health Insurance;Heart Diseases;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Hypertension;Immigrant;Immigration;Individual;Insurance Coverage;interest;intersectionality;Interview;Kidney Diseases;Laboratories;Language;Latinx;Latinx population;Life Experience;Lived experience;Locales;Malignant Neoplasms;marginalized population;member;Mental Health;Methodology;methylation pattern;migration;Native-Born;Not Hispanic or Latino;novel;Outcome;Participant;Pattern;perceived discrimination;Pharmaceutical Preparations;Phase;physical conditioning;Policy Maker;Population;Positioning Attribute;Postdoctoral Fellow;Process;Public Health;Race;racial discrimination;Recording of previous events;Research;Research Project Grants;Scientist;skills;Sleep Apnea Syndromes;Sleeplessness;social;social culture;Social Environment;social factors;social health determinants;social stressor;sociocultural determinant;socioeconomics;stressor;Structure;Surveys;Testing;tool;Training;United States;Variant;Work

PROJECT_TITLE: Noventa Millas: Migration history, genomic ancestry, and health disparities among Cuban immigrants and Cuban-Americans in the United States

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Pregnancy;Prevention;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: PROJECT NARRATIVE The prevalence of neurodevelopmental delays (NDDs) in children has increased, therefore the identification of modifiable risk factors is of utmost importance. The inconclusive evidence on the associations between prenatal and early childhood environmental factors and NDDs and sensitive windows of exposure has been a barrier for the implementation of air pollutant regulations for pregnant women. Therefore, it is critical to accurately quantify the risks of NDDs from environmental exposures and identify vulnerable subpopulations based on socioeconomic status in a large cohort of pregnant women and their children.

PI_NAMEs: PAPATHEODOROU, STEFANIA  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 8 year old;Adverse effects;adverse pregnancy outcome;Age;Air;Air Pollutants;Air Pollution;Area;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior Disorders;Big Data;Birth;Body mass index;Brain;Caring;Characteristics;Chemicals;Child;Childhood;climate change;Clinical Data;Code;cohort;Complex;Confidence Intervals;cost;Data;Data Sources;Databases;Developmental Coordination Disorders;developmental disease;Diagnosis;early childhood;Economics;Education;Elements;Environment;Environmental Exposure;Environmental Risk Factor;epidemiology study;Etiology;Exposure to;Fetus;fine particles;follow-up;Goals;hazard;Health;Health protection;Heat Waves;Heritability;implementation barriers;Incidence;Income;Individual;Infant;innovation;Intellectual functioning disability;Intervention;Joints;Knowledge;Language Disorders;Learning Disabilities;Location;Marital Status;Mediating;Medicaid;Medical;Mental Health;Metals;Methods;Modeling;modifiable risk;Modification;Neurodevelopmental Disorder;Nitrogen Dioxide;non-genetic;novel;Outcome;Ozone;Pathway interactions;Pediatric cohort;pollutant;Pollution;population based;postnatal;Predictive Value;Predisposition;Pregnancy;Pregnant Women;prenatal;Prevalence;Privatization;Productivity;Public Health;Race;Regulation;Research;Resources;Risk;Risk Factors;Role;Sample Size;Scientific Evaluation;sex;Smoking;social;socioeconomic disadvantage;Socioeconomic Status;Source;spatiotemporal;Speech Disorders;Statistical Methods;System;Temperature;Uncertainty;Work

PROJECT_TITLE: A national study on the effects of air pollution and temperature on children's neurodevelopmental outcomes

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative Metalloenzymes perform challenging but essential transformations of inert chemical bonds in biological systems. We seek a unified understanding of how four different metalloenzyme superfamilies control reaction outcomes. These efforts will enable enzyme engineering or targeting for inhibition in pathogens.

PI_NAMEs: BOAL, AMIE K (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Biological;biological systems;chemical bond;chemical reaction;Chemicals;cofactor;comparative;DNA biosynthesis;drug synthesis;Drug Targeting;Engineering;Environment;Enzyme Inhibition;Enzymes;Family;Friends;Maps;metalloenzyme;Metals;Modification;novel;Outcome;pathogen;pathogenic bacteria;Process;Reaction;Route;Structure;System;Technology;tool;Trace Elements;Transition Elements;Work

PROJECT_TITLE: Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative Development of an effective preventive vaccine is essential to achieve long-term immunity against HIV infection. A successful HIV vaccine will likely need to induce potent broadly neutralizing antibodies to circulating viral strains. We seek to comprehensively and rapidly assess the evolution of neutralizing antibody responses induced by candidate Env immunogens to select the most promising vaccine regimens that might eventually induce broad neutralization of contemporary circulatory HIV-1 strains globally.

PI_NAMEs: MCELRATH, MARGARET JULIANA (contact)

PROGRAM_OFFICER_NAME: D'SOUZA, PATRICIA D

PROJECT_TERMS: Acceleration;Antibodies;Antibody Formation;Antibody Response;Antigens;assay development;Award;B cell repertoire;B-Lymphocytes;Binding;Biological Assay;Cancer Center;Clinical Trials;Cryoelectron Microscopy;Data;Data Set;Dedications;design;Development;Electrons;Employment;Epitope Mapping;Epitopes;Equipment;Evaluation;Evolution;expectation;first-in-human;Funding;Generations;genetic signature;Goals;HIV;HIV Infections;HIV vaccine;HIV Vaccine Trials Network;HIV-1;Human;Immunity;Immunologics;improved;Individual;Infrastructure;Knowledge;Laboratories;Light;Memory B-Lymphocyte;Microscopic;Molecular;neutralizing antibody;novel;operation;Pathway interactions;Phase;phase I trial;Phenotype;prevent;Preventive vaccine;Quality Control;Reagent;Regimen;Research Institute;Research Personnel;scale up;Serum;single cell sequencing;Sorting;Specificity;Technology;Testing;Time;Training;Universities;vaccine candidate;Vaccine Clinical Trial;vaccine strategy;vaccine-induced antibodies;Vaccines;Viral;ward

PROJECT_TITLE: HIV Vaccine Trials Network Laboratory Center - B-Cell and Molecular Assay Multi-year Supplement


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

ORG_CITY: COLLEGE PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Narrative The goal of this supplement is to replace an aging piece of chromatography equipment that serves a critical operating function. A new protein purification apparatus will ensure that we maintain the momentum of the parent proposal by timely production of novel hepatitis C virus (HCV) envelope glycoprotein (E1E2) antigens for biochemical, structural, and immunological analysis.

PI_NAMEs: ANDRIANOV, ALEXANDER ;FUERST, THOMAS R (contact);MARIUZZA, ROY A;OFEK, GILAD A;PIERCE, BRIAN G.;PLOSS, ALEXANDER ;SINGH, NEVIL JOHN

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute Hepatitis C;Aging;Animal Model;Antibodies;Antibody Response;Antigenic Diversity;Antigens;Award;B-Lymphocytes;Binding;Biochemical;burden of illness;Chromatography;Cirrhosis;Data;efficacy testing;Ensure;Epitopes;Equipment;Evaluation;experience;Failure;Fibrosis;Funding;Genome;Glycoproteins;Goals;Hepatitis C;Hepatitis C Vaccine;Hepatitis C virus;Immunity;Immunologics;Infection prevention;Liver diseases;Manufacturer;Membrane;neutralizing antibody;novel;Parents;Pathology;Persons;Primary carcinoma of the liver cells;Production;Property;protein purification;Proteins;rational design;Risk;T-Lymphocyte;vaccine evaluation;Viral;virus envelope

PROJECT_TITLE: Rational design and efficacy testing of vaccines against HCV


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Overall: Project Narrative The comprehensive objective of this application is to increase the capacity of the ONPRC AIDS Research expanded SPF Breeding Colony to produce well-characterized Indian-origin rhesus macaques free of a broad number of enzootic and zoonotic agents to enhance their usefulness as a resource for NIH-funded, HIV/AIDS research.

PI_NAMEs: BOHM, RUDOLF PAUL (contact);MARTIN, LAUREN DREW

PROGRAM_OFFICER_NAME: SUI, YONGJUN

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Address;animal resource;Animals;Award;base;Behavioral;Breeding;Caring;Clinical;co-infection;Communities;congenital infection;Cost Savings;Cytomegalovirus;data management;Databases;demographics;Disease;Emerging Communicable Diseases;Ensure;enzootic;Equilibrium;Exclusion;Funding;Funding Agency;Funding Opportunities;Genetic;genetic analysis;genetic testing;Genetic Variation;germ free condition;Goals;Grant;hazard;Herpesvirus 1;HIV/AIDS;Human Resources;immunosuppressed;improved;Income;Individual;Infectious Agent;Infrastructure;Investigation;Link;Lymphocryptovirus;Macaca mulatta;Maintenance;Measles;Measles virus;Medical;Monitor;nonhuman primate;offspring;Opportunistic Infections;Oregon;Pathology;Population Genetics;Population Sizes;Primates;Procedures;Process;Production;Program Description;programs;Records;repaired;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;Rhadinovirus;Rhesus;Simian T-lymphotropic virus 1;SIV;Source;Specific qualifier value;Spumavirus;success;Techniques;Testing;Time;Tuberculosis;Type D Retrovirus;United States National Institutes of Health;vaccine development;Viral;Virus;virus testing;Wages;Zoonoses

PROJECT_TITLE: Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-H (55)]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PI_NAMEs: CULLIN, CASSANDRA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS-Related Opportunistic Infections;Animal Experimentation;Animal Model;animal resource;Animals;assistive reproductive technique;Behavioral;Breeding;Caring;Censuses;Clinical;Containment;Cytomegalovirus;demographics;Derivation procedure;Development;Ensure;Equilibrium;Equity;experience;Female;Fostering;Funding;Future;Genetic Variation;germ free condition;Grant;Growth;Health;Herpesvirus 1;HIV;HIV/AIDS;Housing;Human;Income;Infant;Infectious Diseases Research;Infrastructure;Macaca;Macaca mulatta;Maintenance;male;Measles;Medical;Partner in relationship;Pathogenesis;Patients;Population;Practice Management;Production;programs;recruit;Research;Research Personnel;Research Support;Resources;Rhadinovirus;Rhesus;Shelter facility;Simian Foamy Virus;Simian Retroviruses;SIV;success;Testing;Time;United States National Institutes of Health;Vaccines;Virus

PROJECT_TITLE: Core A: Husbandry & Management Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: HAERTEL, ANDREW  (contact)

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;AIDS-Related Opportunistic Infections;Animal Sources;Animals;Antibodies;Biological Assay;Blood;Breeding;burden of illness;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Detection;Development;Disease;Emerging Communicable Diseases;Enzyme-Linked Immunosorbent Assay;evaluation/testing;Exclusion;Funding;germ free condition;Goals;HIV;HIV vaccine;Human;Immunology;improved;Infant;Infection;Lymphocryptovirus;Macaca;Macaca mulatta;Measles virus;microbial;Modeling;Monitor;nonhuman primate;offspring;Opportunistic Infections;Oregon;pathogen;Pathogenesis;Phase;Play;Population;prevent;Primates;Process;Production;Protein Array;recruit;Research;research and development;Resources;Rhadinovirus;Rhesus;Role;Saliva;screening;Serology;Serology test;Spumavirus;Techniques;Testing;testing services;Tuberculosis;vaccine development;Vaccines;vector vaccine;Viral;Virus;virus host interaction;virus testing

PROJECT_TITLE: Core B: Viral Testing Core


PI_NAMEs: PETERSON, SAMUEL  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Admixture;Alleles;animal breeding;Animal Experimentation;Biological Assay;Biomedical Research;Breeding;Catalogs;Chinese;Communicable Diseases;Complex;Confounding Factors (Epidemiology);Data;Data Analyses;database of Genotypes and Phenotypes;Development;Disease Progression;Ensure;Foundations;Generations;Genetic;genetic analysis;genetic pedigree;genetic testing;Genetic Variation;genome annotation;genome-wide;genomic variation;Genomics;Genotype;germ free condition;Goals;Group Structure;Haplotypes;Health;HIV;Human;Immune response;improved;Individual;Infant;Infection;Infectious Diseases Research;Macaca;Macaca mulatta;Major Histocompatibility Complex;Masks;Measurement;meetings;member;Methods;Modeling;Monitor;Nature;nonhuman primate;novel;offspring;Oregon;pathogen;Pathogenicity;Population;Primates;Procedures;Production;Productivity;recruit;repository;Research;Research Design;Research Personnel;Research Project Grants;research study;Research Support;Resources;response;SIV;social group;Study models;Techniques;Technology;Testing;tool;Update;Variant;Viral Pathogenesis;Work

PROJECT_TITLE: Core C: MHC Genetic Typing Core


ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PI_NAMEs: DUNCAN, MELINDA K (contact)

PROGRAM_OFFICER_NAME: ARORA, KRISHAN

PROJECT_TERMS: Advisory Committees;American Association for the Advancement of Science;Bioinformatics;Biomedical Research;career;Collaborations;Communities;Critiques;Delaware;Development;Disease;Economics;Education;Educational workshop;effectiveness evaluation;Evaluation;experience;Faculty;Funding;Future;Goals;graduate student;Grant;Heart;Human Resources;Impact evaluation;improved outcome;Institution;Leadership;meeting abstracts;Mentors;Mission;Occupations;Pilot Projects;Policies;Principal Investigator;Procedures;Process;Program Development;Program Evaluation;Program Research Project Grants;programs;Publications;Recommendation;Research;Research Activity;research and development;Research Personnel;Resource Sharing;Resources;Services;Strategic Planning;Students;success;symposium;undergraduate student

PROJECT_TITLE: Delaware INBRE


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: The overall goal of this project is to increase numbers of clinical trials and observational cohort studies in Institutional Development Award (IDeA) states that currently have less than 10% of active NIH supported trials. Strategies to accomplish this goal include communicating to trial sponsors the expertise, quality, and capacity of IDeA state institutions to conduct clinical trials and to IDeA investigators available clinical trial opportunities. We will also train a cadre of skilled research coordinators across IDeA states to provide the necessary workforce capacity to conduct increased numbers of trials.

PI_NAMEs: HODDER, SALLY LYNN (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Address;Award;Childhood;Clinical Research;Clinical Trials;Clinical Trials Network;cohort;Communication;Conduct Clinical Trials;Development;Educational Curriculum;Funding;Goals;health care service organization;Institution;institutional capacity;interest;Marketing;member;observational cohort study;Population;programs;Research;Research Personnel;Research Training;Resources;Services;Site;skills;Training;Training Programs;United States National Institutes of Health;workforce needs

PROJECT_TITLE: The IDeA State Consortium for a Clinical Research Resource Center: Increasing Clinical Trials in IDeA States through Communication of Opportunities, Effective Marketing, and WorkforceDevelopment


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Data Science;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Patient Safety;Pediatric;Precision Medicine;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PI_NAMEs: FEASTER, DANIEL J;METSCH, LISA R;SZAPOCZNIK, JOSE  (contact)

PROGRAM_OFFICER_NAME: DOBBINS, RONALD

PROJECT_TERMS: Address;Adolescent;Adult;Area;behavioral health;bioinformatics tool;Caring;Child health care;Clinic;Clinical;Clinical Research;Clinical Treatment;Clinical Trials Network;Cocaine;Collaborations;comorbidity;Data;Data Science;design;Disparity;Dissemination and Implementation;Drug abuse;eHealth;Electronic Health Record;Epidemic;Evidence based treatment;experience;Family;Florida;Foundations;Harm Reduction;health care settings;health economics;Health system;Healthcare;Healthcare Systems;Helping to End Addiction Long-term;Hispanic Populations;HIV;HIV/HCV;Hospitals;implementation science;improved;individual response;Infrastructure;innovation;Intervention;Leadership;Learning;Mainstreaming;Medical;Mental Health;Methamphetamine;Methods;Modeling;National Institute of Drug Abuse;Opiate Addiction;Opioid;opioid misuse;Overdose;patient population;Patients;Pharmaceutical Preparations;point of care;Population;Practice based research;precision medicine;Precision therapeutics;Prevention;Primary Care;Protocols documentation;Public Health;Puerto Rico;Registries;Research;Schools;Science;screening;service delivery;Speed;stimulant use;substance use;success;Technology;Testing;Training;Treatment outcome;treatment response;treatment services;United States National Institutes of Health;Universities;Work


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research

PROJECT_TERMS: Academic Research Enhancement Awards;Area;Award;base;Biomedical Research;cardiovascular health;Cardiovascular system;career;Centers of Research Excellence;Clinical;cohort;Collaborations;Delaware;Development;Dreams;Economic Development;Faculty;Funding;Goals;graduate student;Grant;Health;Health Promotion;Healthcare;improved;Infrastructure;innovation;Institution;instrumentation;Investments;Lead;Literature;Malignant Neoplasms;meeting abstracts;Mentors;Mission;Neurosciences;novel strategies;outreach;Peer Review;Pilot Projects;Postdoctoral Fellow;Program Research Project Grants;programs;Publications;Publishing;Research;Research Personnel;Research Project Grants;Resources;Secure;Services;student participation;Students;undergraduate student;underrepresented minority student;United States National Institutes of Health


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Patient Safety

PHR: PROJECT NARRATIVE FROM PARENT Epilepsy surgery can result in seizure freedom in patients with drug-resistant epilepsy. Current clinical tools that guide surgical decisions are limited, in part due to an incomplete understanding of brain connectivity patterns in focal epilepsy. Using magnetic resonance imaging and intracranial recordings, we will develop new network- based tools that can be applied broadly at epilepsy centers to improve patient selection, outcome prediction, and localization of surgical targets in epilepsy surgery.

PI_NAMEs: ENGLOT, DARIO J (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Ablation;Brain;brain magnetic resonance imaging;Brain region;Clinical;Development;Disabling;Drug resistance;Electric Stimulation;Electroencephalography;Electrophysiology (science);Epilepsy;Evaluation;Evoked Potentials;Excision;Fingerprint;Freedom;Functional Magnetic Resonance Imaging;Generations;Goals;improved;Individual;innovation;Intractable Epilepsy;Magnetic Resonance Imaging;Measurement;Measures;Modality;Modeling;Monitor;multimodality;Network-based;neuroimaging;novel;Operative Surgical Procedures;outcome prediction;Parents;Partial Epilepsies;Pathway Analysis;Patient Care;Patient Selection;Patients;Pattern;research clinical testing;Rest;Scalp structure;Seizures;supervised learning;surgery outcome;Techniques;Testing;tool

PROJECT_TITLE: Development of multimodal network analyses to improve epilepsy surgery outcomes


ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Endothelial cell migration and cell-cell interactions are fundamental processes mediating physiological angiogenesis and they are often dysregulated in human diseases. The proposed project will define how these processes regulated in time and space and identify components of this regulation. The proposed studies will reveal important factors regulating angiogenesis and guide future development of potential therapeutic strategies.

PI_NAMEs: KARGINOV, ANDREI V (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 3-Dimensional;Adherens Junction;Affect;angiogenesis;Blood Vessels;cadherin 5;Cell Communication;cell motility;Cell-Cell Adhesion;Cells;Cytoskeleton;Development;Endothelial Cells;Endothelium;Engineering;Environment;Event;Extracellular Matrix;Extracellular Matrix Degradation;Future;Goals;Growth Factor Receptors;human disease;Integral Membrane Protein;Intercellular Junctions;Invaded;KDR gene;Laboratories;Light;Location;Mediating;migration;novel;optogenetics;Permeability;Phosphorylation;Physiologic Neovascularization;Physiological;Process;Regulation;Research;Role;Signal Transduction;spatiotemporal;Sphingosine-1-Phosphate Receptor;src-Family Kinases;Stimulus;Structure;Therapeutic;Time;tool;Vascular System;Work

PROJECT_TITLE: Regulation of endothelial cell invasion, migration and cell junction plasticity

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science

ORG_CITY: LAS CRUCES

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PI_NAMEs: LUSETTI, SHELLEY  (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Achievement;Award;base;Biomedical Research;career;career development;Centers of Research Excellence;Cloud Computing;cohort;college;Communication;Communities;community based research;community college;Complement;computing resources;Consultations;Core Facility;Data Science;Data Science Core;Development;economic disparity;Educational Status;Educational workshop;Environment;Equipment;Evaluation;evidence base;experience;Faculty;faculty mentor;faculty research;faculty support;Fostering;Funding;Funding Opportunities;genome resource;Government;Grant;Health;Health Sciences;higher education;improved;Infrastructure;Institution;Interdisciplinary Study;Knowledge;Lead;Leadership;Life Style;Measures;Medicine;Mentors;Mentorship;Mexican;Mining;Minority;Minority-Serving Institution;New Mexico;operation;organizational structure;Outcome;Population;Principal Investigator;Process;Productivity;Program Evaluation;Program Research Project Grants;programs;Publications;Reduce health disparities;Research;research and development;Research Personnel;Research Project Grants;Research Support;Research Training;Role;rural area;Services;student participation;student training;Students;success;summer research;symposium;Technology;Training;tribal community;undergraduate student;Universities

PROJECT_TITLE: NM-INBRE Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Hearing Loss;Neurosciences

ORG_CITY: OMAHA

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PI_NAMEs: STEYGER, PETER STEPHEN (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Accountability;Advisory Committees;Biometry;boys;career;Centers of Research Excellence;Clinical Research;Clinical Trials;Collaborations;Data;Dedications;empowerment;Ensure;Environment;Evaluation;Extramural Activities;Feedback;Fees;Funding;Future;Goals;Hearing;hearing preservation;hearing restoration;Hospitals;Human Resources;improved;Information Dissemination;Infrastructure;innovation;Institution;Interdisciplinary Study;International;Journals;Leadership;Manuscripts;Medical;Medical center;meetings;Mentors;Mentorship;Modeling;Monitor;Nebraska;novel therapeutic intervention;novel therapeutics;Office of Administrative Management;operation;Outcome;Participant;Peer Review Grants;Performance;Phase;Pilot Projects;Positioning Attribute;preclinical study;Principal Investigator;Productivity;Program Evaluation;programs;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;Services;Site;sound;Strategic Planning;Structure;success;symposium;Teacher Professional Development;tenure track;Translating;translational impact;Universities;Vestibular function;vestibular system;voucher;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: GALVESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Project Narrative Neuropathic pain is a major public health challenge and is inadequately addressed. The proposed research will identify the role of Ca2+/Calmodulin-dependent protein kinase (CaMKII) in dorsal root ganglion in chronic pain. Completion of the proposed program may lead to new therapeutic pathways for chronic pain by selectively reversing neuropathic pain-induced down-regulated CaMKII activity.

PI_NAMEs: HUDMON, ANDY ;PAN, BIN  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Absence of pain sensation;abuse liability;Action Potentials;Acute;addiction;Address;adeno-associated viral vector;Adult;Afferent Neurons;Analgesics;Anatomy;Animal Model;Binding;Biological Assay;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;Calcium Signaling;Calmodulin;Cell model;Cell Physiology;Cells;Central Nervous System;Chronic;chronic pain;chronic pain management;chronic pain relief;Clinical;Cytoskeleton;Dependovirus;Development;Dinoprostone;Dissociation;dorsal horn;Effectiveness;Electrodes;Engineering;Environment;experimental study;Exposure to;Female;Fiber;Foundations;Generations;Genetic;Genetic Transcription;Histologic;Hyperalgesia;In Situ;In Vitro;in vivo;inhibitor;Injections;insight;Iodoacetates;Knowledge;Learning;Maintenance;male;Measures;Membrane;Memory;Molecular;monomer;Nerve Growth Factors;nerve injury;Neurons;neuroregulation;non-opioid analgesic;novel;novel therapeutics;Opioid;osteoarthritis pain;Pain;pain model;pain reduction;painful neuropathy;Pathway interactions;Patients;Pattern;Peripheral;Peripheral Nervous System;pharmacologic;Phosphorylation;Phosphotransferases;Pre-Clinical Model;presynaptic;Process;programs;Protein Kinase;Protein-Serine-Threonine Kinases;Proteins;Public Health;Rattus;Regulation;Research;Role;Route;Safety;Sample Size;Second Messenger Systems;sensor;Sensory;side effect;Signal Transduction;Site;Slice;Spinal Ganglia;spinal nerve posterior root;Structure of tibial nerve;success;Synaptic plasticity;Synaptic Transmission;Testing;Therapeutic;therapeutic development;Therapeutic Uses;transgene expression;Transgenes;Translations;transmission process;treatment strategy;Trigeminal System;Up-Regulation;Viral;Whole-Cell Recordings;Work

PROJECT_TITLE: Role of Primary Sensory Neuron CaMKII Signaling in Regulation of Pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Neurosciences;Rehabilitation

ORG_CITY: EL CERRITO

ORG_NAME: MAGNETIC TIDES, INC.

ORG_STATE: CA

PHR: Project Narrative We have recently developed a new non-invasive brain stimulation (NIBS) system, kilohertz transcranial magnetic perturbation (kTMP), that opens a new experimental space for safely modulating neural excitability in targeted areas of the human brain. This project will focus on testing the impact of AM-kTMP on a language task by targeting physiologically relevant frequencies to manipulate brain oscillations and speech perception. In addition, the supplementee will conduct customer discovery interviews to test and validate our costumers' segments and our value propositions.

PI_NAMEs: LABRUNA, LUDOVICA  (contact)

PROGRAM_OFFICER_NAME: FORBES, JESSICA CARLENE

PROJECT_TERMS: Appointment;Area;Awareness;Behavioral;Brain;Businesses;career;Cephalic;Clinical;cognitive neuroscience;experimental study;Foundations;Frequencies;Goals;Health Technology;Human;improved;Intervention;Interview;Language;magnetic field;Magnetism;Marketing;medical schools;Modeling;Motor;Motor Skills;neural;Neurologic;neurological rehabilitation;Neurosurgeon;noninvasive brain stimulation;novel;parent grant;Participant;Physiological;Receptive aphasia;Rehabilitation therapy;Research Project Grants;skills;Solid;Speech Perception;System;Testing;Time

PROJECT_TITLE: Exploring the Parameter Space of High Frequency Magnetic Perturbation in Manipulating Neural Excitability and Plasticity.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(10)-B]


ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Fertility requires many levels of interaction between males and females – at the level of gametes and their fates in the reproductive tract and at neural/behavioral levels – and their ultimate success varies dramatically with the genotype of the male and female involved. This variation affects the likelihood of a particular male siring offspring with a given female, due to interactions between male and female components that impact the handling of sperm within the female, and the regulation of genes in her brain. Our proposed studies with a tractable and sensitive model system will uncover the extent and mechanisms by which genetic variation can alter reproductive outcomes, and how these can be predicted analytically for given pairs of interacting animals.

PI_NAMEs: CLARK, ANDREW G (contact);WOLFNER, MARIANA FEDERICA

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Affect;Alternative Splicing;Animals;Automobile Driving;Behavior;Behavioral;Biological Models;Brain;Collection;Complex;Copulation;Data;Differential Fertility;Disadvantaged;Discrimination;Drosophila genus;Ejaculation;Exons;experimental study;father role;Female;female reproductive tract;Fertility;Fertilization;fitness;follow-up;Foundations;Funding;Furuncles;Future;Gene Expression Regulation;Genes;Genetic;Genetic Determinism;Genetic Variation;Genome;genome wide association study;Genotype;Germ Cells;Human;Infertility;Internet;Link;male;Maps;Mediating;Methods;model design;Modeling;Molecular;Nature;neural;Neural Pathways;Neurons;novel;Octopamine;octopamine receptor;offspring;Outcome;outcome prediction;Partner in relationship;Pathway interactions;Perception;Phenotype;Pheromone;Play;Predictive Analytics;Process;Production;programs;promoter;Regulation;Reproduction;reproductive;reproductive fitness;reproductive outcome;reproductive success;reproductive tract;response;Role;Seminal fluid;Series;sex;Sexual Reproduction;Signal Transduction;Sorting;sperm cell;Sperm Count Procedure;Spliced Genes;Sports;Statistical Models;success;Surveys;Testing;Time;Transcript;transcriptome;Validation;Variant;Whole Organism;Work;zygote

PROJECT_TITLE: REGULATION OF GAMETE USE AND NEURAL PATHWAYS IN REPRODUCTION

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: HADLEY

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: Project Narrative We have discovered two new sperm incubation methods based on the regulation of intracellular calcium and metabolic pathways; these methods improve sperm functional parameters which increase the percentage eggs that can be fertilized in vitro and also improve early embryo development and pregnancy rates. From the basic science perspective, this proposal is aimed to understand at the molecular level how intracellular calcium and metabolism interact to enhance sperm function. From the applied point of view, accomplishment of these goals will provide tools for improving current Assisted Reproductive Technology (ART) methods including in vitro fertilization and early embryo development.

PI_NAMEs: VISCONTI, PABLO E. (contact)

PROJECT_TERMS: Affect;Age;Animals;Artificial Insemination;Assisted Reproductive Technology;Back;Basic Science;blastocyst;Bypass;Calcium;Cell division;Couples;Data;design;Development;Economics;egg;Embryo;Embryo Transfer;Embryonic Development;Environmental Risk Factor;Event;experience;experimental study;Exposure to;Female;female reproductive tract;Fertilization;Fertilization in Vitro;Gene Expression;Genetic;genetic approach;Genetic Models;Germ Cells;Glycolysis;Goals;Health;Human;human disease;human model;Implant;implantation;improved;In Vitro;Incubated;Individual;Infertility;Injections;insight;Intracytoplasmic Sperm Injections;intrauterine insemination;Ionophores;Knock-out;Mammals;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methodology;Methods;Molecular;Motility;mouse model;novel;Nutrient;Obesity;offspring;Output;Oxidative Phosphorylation;Pathway interactions;Phosphorylation Inhibition;Physiological;post pregnancy;Pregnancy;Pregnancy Rate;Procedures;Process;programs;Protocols documentation;Publishing;pup;Recovery;Regulation;response;Signal Pathway;Signal Transduction;Site;spatiotemporal;sperm cell;sperm cryopreservation;sperm function;Sperm Motility;Starvation;Sterility;subfertility;Techniques;Test-Tube Baby;Testing;tool;Translating;Uterus;zygote

PROJECT_TITLE: Sperm Ca2+ signaling and energy pathways in basic science and ART

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Sudden Unexpected Death in Epilepsy (SUDEP) accounts for between 8 and 17% of all epilepsy-related deaths and, although our understanding of SUDEP is rudimentary, there is increasing evidence that respiratory arrest after a convulsive seizure is the primary cause in many cases. In support of this, we have found that seizure-induced apnea that occurs during the tonic phase and failure of postictal breathing recovery produce SUDEP in mouse models. Using novel mouse models of SUDEP, we propose to use chemogenetic, optogenetic, and electrophysiological techniques to elucidate the underlying neural circuitry that is recruited to cause seizure-induced apnea and SUDEP.

PI_NAMEs: WENKER, IAN CHRISTOPHER (contact)

PROJECT_TERMS: Acute;Address;afferent nerve;Apnea;Benchmarking;Brain;Brain Mapping;Brain Stem;Breathing;Bypass;Cardiac;Cause of Death;Cell Nucleus;Cessation of life;Chromosome Mapping;Clonic Seizure;Data;Development;Electrophysiology (science);Elements;Epilepsy;Experimental Designs;Failure;FOXP2 gene;Generations;Genetic;Heart Arrest;hindbrain;In Vitro;in vivo;Individual;Injections;Interruption;Maps;Midbrain structure;Modeling;Motor Seizures;mouse model;Mus;Muscle;mutant;Mutant Strains Mice;Mutation;National Institute of Neurological Disorders and Stroke;Nerve Fibers;neural;neural circuit;neuronal circuitry;neuronal excitability;Neurons;Nodal;novel;optogenetics;parabrachial nucleus;patch clamp;Patients;Pattern;Phase;Pontine structure;prevent;Prevention strategy;Prosencephalon;receptor;Recovery;recruit;Refractory;Research;respiratory;Respiratory Failure;Risk Factors;Role;SCN8A gene;Seizures;selective expression;Site;Slice;Structure;Sudden Death;sudden unexpected death in epilepsy;Techniques;Testing;Tonic Seizures;Vagus nerve structure;ventilation;Work

PROJECT_TITLE: The neural circuitry of seizure-induced apnea and SUDEP

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: DMITROVSKY, ETHAN  (contact)

PROJECT_TERMS: Laboratories

PROJECT_TITLE: FY22 - APA BUILDINGS - BUILDING 2


PROJECT_TITLE: FY22 - APA BUILDINGS - BUILDING 1


PROJECT_TITLE: THIS IS A CPFF TO TO REFURBISH APA BUILDINGS 1034


PROJECT_TITLE: THIS IS A CPFF TO TO REFURBISH APA BUILDINGS (1033).


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SAINT CHARLES

ORG_NAME: EUROFINS PANLABS, INC.

ORG_STATE: MO

PI_NAMEs: GALLAGHER, ANTHONY  (contact)

PROJECT_TERMS: Biological;Biological Assay;Chemistry;Communicable Diseases;Development;Development Plans;Drug Kinetics;Evaluation;In Vitro;in vivo;Interventional Agent Development;Lead;lead optimization;manufacture;pathogen;pre-clinical;product development;programs;Property;Rodent;Safety;screening;Services;Therapeutic;therapeutic development;Toxicology;Toxin

PROJECT_TITLE: Task E13: Lead Optimization Screening Assays for ADMET, Safety Profiling, Rodent Pharmacokinetics and MTD


FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

NIH_SPENDING_CATS: Cancer

ORG_NAME: NATIONAL CANCER INSTITUTE

PROJECT_TITLE: NCI Enterprise Vocabulary Services (EVS) and Operations Acquisition Services


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project narrative Fear and anxiety underlie the most common forms of mental illness in the United States, with more than 30% of Americans experiencing an emotional disorder at some point in their life. Consequently, a major goal of NIH is to understand the neural mechanisms that underlie adaptive and maladaptive threat processing. The hippocampus and locus coeruleus both contribute to fear and anxiety, but it is not known how they interact during these states to promote the encoding of aversive memories. This represents a major gap in our understanding of the neural systems that contribute to emotional disorders. Altered catecholamine release by the locus coeruleus accompanies schizophrenia, bipolar disorder, and ADHD, which are often comorbid with fear and anxiety disorders. Alzheimer’s disease also produces severe atrophy of the locus coeruleus, which reduces catecholamine release throughout the brain and is thought to exacerbate amnesia. To determine how altered catecholamine levels impact these disorders, it is essential to establish the basic mechanisms by which neuromodulatory inputs to the hippocampus regulate the formation of aversive memories.

PI_NAMEs: WILTGEN, BRIAN J (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Alzheimer's Disease;American;Amnesia;Animals;Anxiety;Anxiety Disorders;Association Learning;Atrophic;Attention deficit hyperactivity disorder;Auditory;aversive conditioning;Aversive Stimulus;Bipolar Disorder;Brain;Catecholamines;comorbidity;conditioned fear;Cues;Data;Disease;Dopamine;Dopamine Antagonists;Dopamine Receptor;Dorsal;Electrophysiology (science);Emotional disorder;emotional experience;Environment;Event;experience;experimental study;Extinction;follow-up;Food;Fright;Future;Genetic;Goals;Hippocampus;Hour;Human;Impairment;in vivo;Learning;Life;locus ceruleus structure;long term memory;member;Memory;memory consolidation;Memory impairment;memory process;Mental disorders;Monitor;neural;neuromechanism;Neuromodulator Receptors;Neurons;neuroregulation;Norepinephrine;novel;optogenetics;Play;prevent;Procedures;Process;psychologic;Rattus;rehearsal;response;Role;Schizophrenia;sensor;Shock;Stimulus;Synaptic plasticity;System;Testing;Time;tool;Training;United States;United States National Institutes of Health

PROJECT_TITLE: The role of novelty and surprise in aversive conditioning

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHOENIX

ORG_NAME: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER

ORG_STATE: AZ

PHR: Project Narrative The proposed studies will provide novel information on the role of microglia in disease mechanisms and neuronal dysfunction in C9orf72 patients clinically diagnosed with frontotemporal dementia (FTD). While microglia activation is known to occur in this patient population through postmortem autopsy studies, a much better understanding is needed regarding the extend of microglia-neuron co-regulation and the existence or absence of non-cell autonomous disease mechanisms similar to what has been described for astrocyte and motor neurons in other neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). The proposed studies will provide novel opportunities for drug target identification and future drug discovery efforts with the hope of identifying novel therapeutics for these affected patient populations.

PI_NAMEs: HUENTELMAN, MATT ;SATTLER, RITA  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Area;Astrocytes;Autopsy;Brain;Brain region;C9ALS;c9FTD/ALS;C9ORF72;Candidate Disease Gene;cell cortex;Cell Differentiation process;Cell Line;cell type;Cells;chemokine;Clinical;clinical diagnosis;Coculture Techniques;Communication;cytokine;Data;Data Set;Dementia;density;Department of Defense;Development;Dipeptides;Disease;disease phenotype;drug discovery;Drug Targeting;Etiology;Executive Dysfunction;executive function;Expression Profiling;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Funding;Future;Gene Expression Profile;Gene Expression Profiling;Genes;genetic profiling;Gliosis;Goals;Hot Spot;Human;human induced pluripotent stem cells;Immune;Immunohistochemistry;Impaired cognition;In Vitro;Induced pluripotent stem cell derived neurons;Investigation;Knowledge;Label;Laboratories;Lysosomes;Maintenance;Measures;Microglia;Modeling;Molecular;molecular phenotype;Morphology;Motor Neurons;Mutation;Nerve Degeneration;neural;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;Neuronal Dysfunction;neuronal excitability;neuronal survival;Neurons;neuropathology;novel;novel therapeutics;Outcome;Pathogenesis;Pathologic;Pathology;patient derived induced pluripotent stem cells;patient population;patient subsets;Patients;PGRN gene;Phagocytes;Phenotype;pluripotent stem cell differentiation;Prefrontal Cortex;Process;Property;Prosencephalon;protein expression;protein TDP-43;Proteins;Reporting;RNA;Role;single nucleus RNA-sequencing;single-cell RNA sequencing;Specificity;Symptoms;Synapses;System;Time;Tissue-Specific Gene Expression;Tissues;transcriptome;transcriptome sequencing;Validation;Variant

PROJECT_TITLE: Microglia contribution to disease pathogenesis in C9orf72 ALS/FTD

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Much of human perception and behavior is governed by functioning brain networks. This project will develop a method for generating human cortico-striatal organoids from stem cells and demonstrate that these organoids can be used to model the development of human cortico-striatal networks. The ability to create patient-specific cortico-striatal organoids for use in a variety of laboratory analyses will provide a new approach to enable patient-specific diagnostics and treatments associated with disorders of cortico-striatal connectivity, including autism, schizophrenia, epilepsy, and mood disorders.

PI_NAMEs: SHCHEGLOVITOV, OLEKSANDR  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: 3-Dimensional;Action Potentials;Address;Affect;Anatomy;Animal Model;Astrocytes;autism spectrum disorder;Behavior;Brain;Brain Diseases;Brain region;brain tissue;Cells;Chronic;Coculture Techniques;Communication;Complex;Corpus striatum structure;Development;Diagnostic;Disease;disease model;drug discovery;Electrodes;Electrophysiology (science);Epilepsy;excitatory neuron;Exhibits;experimental study;Functional impairment;Genetic Materials;Human;human model;human stem cell-derived;human stem cells;Huntington Disease;Immunohistochemistry;Implant;inhibitory neuron;innovation;insight;Laboratories;Major Depressive Disorder;Mental disorders;Methods;model development;Modeling;Molecular;Molecular Abnormality;Mood Disorders;Morphology;multi-electrode arrays;nerve stem cell;Nervous System;Nervous System Disorder;neural;neural network;Neurons;novel;novel strategies;novel therapeutics;Oligodendroglia;optogenetics;Organoids;Parkinson Disease;patch clamp;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Perception;Phelan-McDermid syndrome;Phenotype;Physiological;Physiology;Population;precision drugs;prevent;Property;Protocols documentation;Quantitative Reverse Transcriptase PCR;rabies viral tracing;Reproducibility;Schizophrenia;Science;self organization;single cell mRNA sequencing;single-cell RNA sequencing;Slice;stem cell organoids;Synapses;System;system architecture;Techniques;Testing;Time;With laterality;Work

PROJECT_TITLE: Assembly and characterization of human cortico-striatal neural networks


ORG_CITY: AMSTERDAM

ORG_COUNTRY: NETHERLANDS

ORG_FIPS: NL

ORG_NAME: NETHERLANDS CANCER INSTITUTE

PHR: PROJECT NARRATIVE Background parenchymal enhancement (BPE) is a promising new marker of breast cancer risk that has been studied almost exclusively using magnetic resonance imaging, an expensive screening modality that is indicated primarily for women with high risk of breast cancer. We propose here to measure BPE quantitatively using contrast-enhanced mammogram (CEM), a rapidly emerging screening modality that is more affordable and generalizable than MRI, and assess the potential of BPE measured on CEM as a marker of breast cancer risk. Our long-term goal is to use our new, objective measure of BPE on CEM to improve assessment of breast cancer risk, enabling personalization of breast cancer screening to detect breast cancer earlier and ultimately reduce breast cancer mortality.

PI_NAMEs: WATT, GORDON PATRICK (contact)

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: Accounting;Address;Agreement;American College of Radiology;Area;Board Certification;Body mass index;Breast;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer Early Detection;Breast Cancer Epidemiology;Breast Cancer Risk Factor;breast imaging;cancer diagnosis;cancer risk;Case/Control Studies;Clinical;Collaborations;Contralateral Breast;contrast enhanced;Contrast Media;density;Diagnosis;Early Diagnosis;Ethnic Origin;Frequencies;Goals;high risk;high risk population;High Risk Woman;Image;imaging biomarker;improved;Information Systems;Injections;Machine Learning;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic Density;Mammographic screening;Mammography;Matched Case-Control Study;Measurement;Measures;Metabolic;Methods;Modality;Modeling;Modification;mortality;Newly Diagnosed;novel marker;Outcome;Participant;Patients;Population;Population Heterogeneity;pressure;prevent;Process;Prospective Studies;Race;radiologist;Radiology Specialty;Random Allocation;Reader;Recording of previous events;Reporting;Reproducibility;Reproductive History;Research;Risk;Risk Assessment;Risk Marker;Roentgen Rays;Schedule;screening;screening guidelines;success;Testing;Tissues;tomosynthesis;uptake;Woman

PROJECT_TITLE: Quantitative background parenchymal enhancement, measured on contrast-enhanced mammogram, as a novel marker of breast cancer risk

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: This study will identify interactions between splicing and transcriptional machineries important for the regulation of phototransduction genes and, thus, contribute to our understanding of retinal homeostasis. This work would provide candidate protein and genomic targets for therapeutic intervention in retinal disease.

PI_NAMEs: CORSO-DIAZ, ELSA XIMENA (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Adult;Alternative Splicing;Area;Binding;Biochemical;Biological Assay;Blindness;Brain;career;Cell Culture System;cell type;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Complex;Computer Analysis;Confocal Microscopy;Coupled;Coupling;crosslink;Data;Defect;Development;Disease;disease-causing mutation;DNA;DNA-Directed RNA Polymerase;Electroporation;Elements;Environment;Eukaryotic Cell;Exons;experimental study;Funding Opportunities;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Research;Genetic Transcription;Genomic approach;Genomic Segment;Genomics;Goals;Grant;helicase;Heterogeneous-Nuclear Ribonucleoprotein Group M;high throughput technology;Homeostasis;Human;human disease;In Vitro;in vivo;knock-down;Laboratories;Ligation;Light;Mass Spectrum Analysis;Mediating;Messenger RNA;Molecular;Molecular Genetics;Morphology;mRNA Precursor;Mus;Mutation;Nervous System;Neurons;new technology;Nuclear;Organoids;Outcome Study;Output;Pathway interactions;Pattern;Photons;Photoreceptors;Phototransduction;Polymerase;programs;Protein Isoforms;protein protein interaction;Protein Splicing;Proteins;Regulation;Research;Resolution;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;Retinal Dystrophy;Retinal Photoreceptors;retinal rods;Rhodopsin;RNA;RNA Interference;RNA Polymerase II;RNA Splicing;Rod;Role;Running;Scientist;Sorting;Spliceosomes;targeted treatment;Testing;Therapeutic Intervention;Transcript;Transcription Elongation;transcription factor;Transcriptional Regulation;transcriptome sequencing;transmission process;Vision research;visual dysfunction;visual stimulus;Work

PROJECT_TITLE: Molecular mechanisms of transcriptional regulation of phototransduction genes in mammalian rod photoreceptors


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PI_NAMEs: BARNOUD, THIBAUT  (contact)

PROJECT_TERMS: African American population;Amino Acids;Apoptosis;Bioinformatics;Biological;Cancer cell line;Cell Cycle Arrest;Cell Death;cell injury;Cell Line;Cells;Centers of Research Excellence;Cirrhosis;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Cytoprotection;Data;Defect;Digestive System Disorders;Disease;disorder risk;DNA Damage;Doctor of Philosophy;efficacious treatment;environmental stressor;Fibrosis;Genes;Genetic Engineering;Genetic Polymorphism;Genetically Engineered Mouse;Goals;Growth;Human;Impairment;Individual;Iron;Iron Overload;Knock-in;Laboratories;Lipids;Liver;liver cancer model;Liver diseases;Liver Fibrosis;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Mentors;mouse model;Mus;Mutation;Oncogene Activation;personalized therapeutic;Population;Predisposition;Primary carcinoma of the liver cells;Proteins;Reactive Oxygen Species;Reporting;response;Risk Factors;senescence;Single Nucleotide Polymorphism;Somatic Mutation;Testing;Tissues;TP53 gene;tumor;Tumor Suppression;Tumor Suppressor Proteins;Variant

PROJECT_TITLE: The impact of p53 variants on liver disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Despite advances in medical and antiretroviral therapy, rates of cerebrovascular disease are increasing in people with HIV, and cognitive impairment and structural brain changes are still observed in treated people with HIV. These non-communicable complications of HIV threaten to put a significant strain on health systems in coming years, and will most affect low resource settings where rates of HIV are highest. The objective of this proposal is to understand the onset and pathophysiology of systemic and central nervous system vasculopathy in people with very early HIV infection, and to identify biomarkers of endothelial dysfunction that can be targeted for early interventions to improve cerebrovascular health in this population globally.

PI_NAMEs: HOLROYD, KATHRYN  (contact)

PROGRAM_OFFICER_NAME: SRINIVASAN, SUDHA

PROJECT_TERMS: Acceleration;Acute;Affect;Aftercare;antiretroviral therapy;Applications Grants;Biological Markers;biomarker identification;Blood;Blood Vessels;Brain;brain health;Cardiovascular Diseases;Cardiovascular system;Central Nervous System;cerebral atrophy;Cerebrovascular Disorders;cerebrovascular health;Chronic;co-infection;cognitive testing;cohort;Cohort Studies;comorbidity;comparison control;cost;cost effective;COVID-19;Data;design;Development;Diagnosis;Disease;Disease Progression;Drug usage;early detection biomarkers;Early identification;Early Intervention;endothelial dysfunction;Endothelium;Enrollment;Event;Functional disorder;Funding;Future;global health;Goals;Health;Health system;Heterogeneity;high risk;HIV;HIV Infections;HIV Seronegativity;illness length;Image;imaging biomarker;Impaired cognition;improved;indexing;Infection;Intervention;Knowledge;Lipids;Longitudinal cohort;Magnetic Resonance Imaging;Measurable;Measurement;Measures;Medical;neurocognitive disorder;neurocognitive test;neuroimmunology;Neurologic;Neuronal Injury;novel;Participant;Peripheral;Persons;Pilot Projects;Population;predictive marker;prevent;preventive intervention;Process;prospective;Prospective Studies;reactive hyperemia;Research;Resource-limited setting;Risk;Scientist;Stroke;stroke risk;Testing;Thailand;Time;Training;Translational Research;Vascular Dementia;Vascular Diseases;Viral;Virus Diseases;White Matter Disease;White Matter Hyperintensity;Work

PROJECT_TITLE: Systemic and Central Nervous System Vasculopathy in Acute HIV and After Early Antiretroviral Therapy

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The suprachiasmatic nucleus (SCN), the locus of the brain’s circadian clock, plays a critical role in mediating circadian rhythmicity of numerous important functions; these actions are achieved via a combination of hard-wired and diffusible signals. We recently identified a new portal system connecting the SCN and the organ vasculosum of the lamina terminalis (OVLT), which stands as a candidate route mediating diffusible signals from the SCN. Using a multidisciplinary approach in the proposed study, we will investigate the precise anatomical sources and targets of this novel portal system and determine directionality of blood flow and its regulation to generate novel information on mechanisms that mediate orchestration of circadian rhythmicity of multiple tissue targets by the SCN.

PI_NAMEs: STERN, JAVIER E (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Address;Anatomy;Basic Science;Behavioral;behavioral response;Blood flow;Blood Vessels;Brain;Cerebrospinal Fluid;circadian;circadian pacemaker;circadian regulation;Data;design;Diabetes Mellitus;Disease;Distant;Environment;Functional disorder;Future;Goals;Health;Heart Diseases;Human;Hydration status;Image;Impaired cognition;in vivo;Individual;interdisciplinary approach;Investigation;Knowledge;Lamina Terminalis;Life;Light;Location;Mammals;Mediating;Mental Depression;Modality;Mus;Names;Neuropeptides;novel;Obesity;Operative Surgical Procedures;Organ;organum vasculosum of the lamina terminalis;Output;parent grant;Pathway interactions;Periodicity;Peripheral;Photic Stimulation;Physiological;Pituitary Gland;Planet Earth;Play;Portal System;Process;Property;Rattus;receptor;Regulation;Research;Resolution;response;Role;Route;Signal Transduction;Site;Societies;Source;Structure;suprachiasmatic nucleus;Synapses;System;Techniques;Time;Tissues;Travel;Vasopressins;Work

PROJECT_TITLE: Novel SCN-OVLT portal system: Dissecting Anatomical and Functional Properties