NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Coronary artery disease is a major cause of death around the globe, yet there are currently no strategies to regenerate diseased coronary arteries. We hypothesize that studying how the developing embryo builds coronary arteries from the ground up could reveal ways of rebuilding them in diseased hearts. We identified candidate developmental pathways during the previous funding period, and propose here to study whether and how these pathways stimulate coronary regeneration.

PI_NAMEs: RED-HORSE, MARY  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Anatomy;Angiogenic Proteins;Arteries;Automobile Driving;Biology;Blood capillaries;Blood flow;blood perfusion;Blood Preservation;Blood Vessels;Bypass;candidate identification;Cardiac;cardiac regeneration;cardiac vasculature;cardiogenesis;Cardiovascular system;Cause of Death;cell behavior;Cell Differentiation process;Cells;chemokine;ChIP-seq;Clinical;collaborative environment;Communities;Computer Models;Coronary;Coronary Arteriosclerosis;Coronary artery;CXCR4 gene;Data;Development;Developmental Gene;Embryo;Endothelial Cells;Ensure;Equus caballus;experimental study;Fibroblast Growth Factor;Funding;gain of function;Gene Expression;Genes;Genetic Transcription;Goals;Growth;Heart;Heart Diseases;Heart Injuries;Human;Image;Imaging technology;In Vitro;in vitro Model;in vivo;injured;Injury;innovation;Knowledge;Laboratories;Learning;loss of function;Maps;mechanotransduction;Medical;Methods;Modeling;Molecular;Morphogenesis;Myocardial Infarction;Myocardial Ischemia;Myocardium;Natural regeneration;Neonatal;novel;novel imaging technique;novel strategies;Operative Surgical Procedures;Organ;Outcome;overexpression;Oxygen;Pathway interactions;Patients;Pattern;protein expression;Recovery;Regimen;reparative capacity;Research;Research Personnel;Resolution;revascularization;Signal Transduction;Stromal Cell-Derived Factor 1;Structure;success;Techniques;Testing;Therapeutic Intervention;Tissue Survival;Tissues;transcription factor;Transcriptional Regulation;transcriptome sequencing;Travel;Trees;Universities;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Mechanotransduction and transcriptional regulation during artery development

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: NEWARK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_FIPS: US

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Adolescence is an important period in social and cognitive development, and social isolation during this developmental stage has long-lasting impacts on physical and mental health. Value-based decision making, or how we make decisions about the costs and benefits of alternative options, is a crucial aspect of daily life. This project will uncover how adolescent social isolation alters these complex decision-making behaviors in adulthood, as well as the underlying neural circuitry.

PI_NAMEs: HOLLY, ELIZABETH N. (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;Automobile Driving;Award;Behavior;Behavioral;career;Choice Behavior;Cognitive;cognitive development;Communication;Complex;Computer Models;Corpus striatum structure;cost;Costs and Benefits;Coupling;COVID-19;COVID-19 impact;Data;Decision Making;Dendritic Spines;Development;discounting;Electrophysiology (science);Ensure;expectation;experimental study;Faculty;Female;flexibility;Foundations;Goals;Habits;Holly;Human;Impairment;in vivo;Intervention;Laboratory Research;Learning;Life;Long-Term Effects;male;Measures;Medial;Mediating;Mental Health;Mentored Research Scientist Development Award;Mentorship;Modeling;Motivation;Motor;Mus;neural;neural circuit;neural network;Neurons;optogenetics;Outcome;Output;Performance;Phase;physical conditioning;Physiological;Positioning Attribute;Prefrontal Cortex;Process;Research;response;Rewards;Rodent;school closure;Signal Transduction;Social Development;Social Interaction;Social isolation;stay-at-home order;Stimulus;Stress;Synapses;Techniques;tenure track;Testing;Thalamic structure;Training;Work

PROJECT_TITLE: Effects of adolescent social isolation on adult decision making and corticostriatal circuitry

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: MADISON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE We have made the striking discovery that deletion of a key stress response gene, Atf6, in β-cells of a type 1 diabetes (T1D) preclinical model confers protection against T1D by inducing a previously not recognized multi- pronged pro-survival adaptative mechanism. We will investigate the regulation of β-cell-immune cell dialogue as well as the molecular mechanisms of diabetes protection in β-cell-specific Atf6-deficient mice and test the translatability of our work in stressed human islets. Our work will provide valuable insight on the molecular mechanisms of adaptive and maladaptive stress responses in β-cells during T1D progression and thus holds the potential to reveal new therapeutic strategies or targets for T1D.

PI_NAMEs: ENGIN, FEYZA  (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Acute;acute stress;Antioxidants;Apoptosis;Apoptotic;ATF6 gene;Autoimmune;B-Lymphocytes;Beta Cell;Binding;Biochemical;biological adaptation to stress;Biological Assay;Cell Communication;Cell Cycle Arrest;Cell Death;Cell Physiology;Cell Survival;cell type;Cells;Cellular Stress;Chemicals;Chronic;Communities;coping;Data;Development;Diabetes Mellitus;diabetes pathogenesis;Disease;DNA Damage;Endoplasmic Reticulum;endoplasmic reticulum stress;Environmental Risk Factor;Etiology;Exhibits;Exposure to;Failure;functional loss;Future;Gene Expression;Gene Expression Profile;gene repression;Genes;Genetic Models;Genetic Transcription;Goals;Graft Survival;Homeostasis;Human;Immune;Immune system;improved;in vivo;Inbred NOD Mice;Incidence;Individual;Inflammation;insight;Insulin;Insulin-Dependent Diabetes Mellitus;insulitis;islet;Knowledge;knowledge base;Leukocytes;Light;loss of function;M cell;Mediating;Membrane;migration;Modeling;Molecular;mouse model;Mus;Non obese;novel;novel therapeutic intervention;Outcome;Pathologic;Pathology;Pathway interactions;Patients;Physiological;Play;pre-clinical;Pre-Clinical Model;programs;promoter;protein misfolding;Proteins;Reagent;Regulation;Repression;Resources;response;Role;sensor;Signal Pathway;Signal Transduction;Sorting;Stress;Structure of beta Cell of islet;System;T-Cell Activation;Techniques;Testing;Therapeutic;TP53 gene;Transcriptional Regulation;transcriptome;translational approach;Up-Regulation;Work

PROJECT_TITLE: The role of beta cell ATF6 in type 1 diabetes

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Nanotechnology;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: SURGERY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The outreach goal of the proposed research project is to develop a new combination of targeted drug delivery and immunotherapy for the treatment of advanced pancreatic cancer. Our innovative designs of tumor penetrating and immune modulating theranostic nanoparticles, coupled with a novel nanoparticle PD-L1 inhibitor (Nano-iPD-L1), enable efficient delivery of chemotherapy drugs and immunotherapy agents into stroma-rich pancreatic cancer tissues to destroy drug resistant tumor cells, modulate an immunosuppressive microenvironment into a pro-immune environment, and generate strong immune responses. Results of this translational research project have the potential for the development of a targeted and image-guided cancer therapy that significantly enhances therapeutic efficacy, and activates tumor specific immune response, and improves survival of pancreatic cancer patients.

PI_NAMEs: MAO, HUI ;YANG, LILY  (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: advanced pancreatic cancer;Affinity;Basement membrane;Biodistribution;Biological;Biology;cancer classification;cancer immunotherapy;Cancer Model;cancer therapy;cancer type;Catalytic Domain;CD8B1 gene;cell killing;cell type;Cells;checkpoint therapy;chemotherapy;Clinical;Combined Modality Therapy;Coupled;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Dendritic Cells;design;Development;Disease;Distant;Dose;Doxorubicin;draining lymph node;Drug Carriers;Drug Delivery Systems;drug distribution;Drug Kinetics;Drug Monitoring;Drug resistance;Drug Targeting;Duct (organ) structure;Effector Cell;effector T cell;Engineering;Environment;Extracellular Matrix;Fibroblasts;Goals;Human;image guided;image guided therapy;image-guided drug delivery;imaging agent;Immune;immune cell infiltrate;immune checkpoint;Immune response;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;Infiltration;innovation;irinotecan;iron oxide nanoparticle;ITGAX gene;KRAS oncogenesis;Lead;Ligands;Macrophage;Magnetic Resonance Imaging;Magnetism;Malignant neoplasm of pancreas;Malignant Neoplasms;migration;MMP14 gene;Modeling;Monitor;mouse model;Mus;Myeloid-derived suppressor cells;nanoparticle;nanoparticle delivery;nanoparticle drug;neoplastic cell;novel;novel therapeutics;outreach;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;pancreatic neoplasm;patient derived xenograft model;PDL1 inhibitors;Penetration;Peptides;peptidomimetics;Pharmaceutical Preparations;Phenotype;PLAUR gene;Population;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;Property;Proteins;Recombinants;Regulatory T-Lymphocyte;Research;Research Project Grants;Resectable;response;sialic acid binding Ig-like lectin;Signal Transduction;Spleen;Stromal Cells;success;targeted cancer therapy;targeted delivery;targeted treatment;theranostics;Therapeutic Effect;therapy resistant;Tissues;Transgenic Mice;Translational Research;Translations;Treatment Efficacy;treatment response;tumor;tumor growth;Tumor Promotion;tumor-immune system interactions;Urokinase Plasminogen Activator Receptor

PROJECT_TITLE: Stroma penetrating and immune modulating nanoparticles for image-guided therapy of pancreatic cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-V(02)M]


NIH_SPENDING_CATS: Clinical Research;Diabetes;Infectious Diseases;Microbiome;Urologic Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Treatment of urinary tract infections (UTI) is a major medical economic burden, and certain populations including diabetic women are at an increased risk of infection and severe complications. This proposal will investigate how dysfunctional metabolism in diabetes alters critical host antimicrobial defenses, bacterial virulence, and the vaginal microbiota, which frequently is a reservoir for uropathogens. These studies seek to understand the molecular mechanisms diminishing host defenses during metabolic disease to inform new therapeutic targets that can treat or prevent UTI.

PI_NAMEs: PATRAS, KATY  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Address;Adherence;Adult;Antibiotics;antimicrobial;Automobile Driving;Binding;Biological;Biological Models;Bladder;blood glucose regulation;Cells;Cessation of life;Clinical;Clinical Management;collaborative environment;college;Complex;Curiosities;Data;Defect;Diabetes Mellitus;diabetic;Diabetic mouse;Disparate;Economic Burden;Elderly;Environment;Epithelium;fitness;Genitourinary system;Genitourinary System Infection;Gestational Diabetes;Glucose;Glycoproteins;Goals;Group B Streptococcus colonization;Health Care Costs;Hospitalization;Host Defense;Image;Immune;immune function;Immune response;immunoregulation;Impairment;In Vitro;in vivo;in vivo Model;Individual;Infection;infection management;infection risk;innovation;insight;kidney infection;Knowledge;Leukocytes;Mediating;Medical;Medical Economics;Medicine;Metabolic Diseases;Metabolic dysfunction;metabolic profile;Metabolism;metabolome;microbial;microbial community;microbiome;microbiota;microbiota composition;Modeling;Modernization;Modification;Molecular;Morbidity - disease rate;mouse model;Mus;Nature;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;opportunistic pathogen;Oral;pathogen;Pathway interactions;Patients;permissiveness;Polysaccharides;Population;Predisposition;prevent;Process;Proteins;Publishing;recruit;Recurrence;Research;response;Role;Sialic Acids;Site;Specimen;Streptococcus Group B;Structure;Testing;Therapeutic;tool;Transgenic Mice;United States;urinary;Urinary tract;Urinary tract infection;urogenital tract;Uropathogen;Vagina;vaginal microbiota;Virulence;Woman

PROJECT_TITLE: Contribution of immune modulation, metabolism, and microbiota to Group B Streptococcal urinary tract infection

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARATIVE: Although antimalarial drugs are critical for reducing disease incidence and transmission, resistance has emerged against every modern antimalarial drug within twelve years of clinical introduction, including to the current first-line artemisinin combination therapies (ACTs). This proposed study will apply two separate approaches to identify new drug targets for which parasite resistance would be unlikely to arise, opening new avenues for the development of long-lasting resistance-resistant antimalarial therapies. One approach will focus on identifying collateral sensitivities in parasites resistant to a wide range of drugs, while the second will identify host serum metabolites critical for asexual replication and production of transmission-competent Plasmodium falciparum parasites.

PI_NAMEs: LLINAS, MANUEL  (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: 5 year old;Address;Anti-malarial drug resistance;Anti-malarials;Architecture;Artemisinins;asexual;Biochemical;Biological Assay;Blood;Cessation of life;Child;Clinical;Combined Modality Therapy;Culicidae;Dependence;design;Development;Disease;Dropout;drug development;drug discovery;Drug resistance;drug resistance development;Drug resistance pathway;drug sensitivity;Drug Targeting;drug-sensitive;empowerment;Environment;Enzymes;Evolution;experience;Exposure to;Future;Genetic;global health;Goals;Growth;Human;Incidence;Individual;Infection;inhibitor;innovation;Integration Host Factors;International;Intervention;knock-down;Life Cycle Stages;Malaria;Mass Spectrum Analysis;Measures;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modernization;new therapeutic target;novel;novel strategies;Nutrient;Nutritional;Parasite resistance;Parasites;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Plasmodium falciparum;pressure;Probability;Process;Production;Proliferating;Resistance;Resistance development;resistant Plasmodium falciparum;response;Serum;Serum-Free Culture Media;small molecule;Techniques;transmission process;Variant;virtual;Virulent

PROJECT_TITLE: Discovering resistance-resistant antimalarial drug target

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIRT-J(01)]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: PHILADELPHIA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative/Public Health Relevance: Interdisciplinary, co-operative research to advance knowledge in the demography and economics of aging requires an adaptive scientific infrastructure. The Population Aging Studies Center at the University of Pennsylvania is an intellectual platform at the crucial juncture of the behav- ioral, social, and health sciences. The accounting and analytic frameworks of PARC, anchored in demography and health economics, provides insights to help meet the research and evidence needs to promote successful and equitable aging for individuals, and to inform effective health policy responses in aging societies, in the U.S. as well as globally.

PI_NAMEs: COE, NORMA B;KOHLER, HANS-PETER  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Academia;Accounting;acute care;Adult;Age;Aging;aging population;aging process;Alzheimer's disease related dementia;Arts;Basic Science;Behavior;Behavioral Sciences;Biological;career;Caregivers;Childhood;Cognition;Cognitive aging;cohort;Collaborations;Communicable Diseases;Data;Data Collection;data resource;Demography;Development;disabled;dissemination strategy;Economics;Education;Ensure;Equity;Ethnic Origin;evidence base;experience;Faculty;Family;frontier;Gender;gene environment interaction;Geography;Health;health disparity;health economics;health inequalities;Health Policy;Health Sciences;Healthcare;Healthcare Systems;Impaired cognition;Individual;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;interest;International;Investigation;Knowledge;Leadership;Life;Life Cycle Stages;Long-Term Care;Measures;Medical;medical schools;member;mortality;multidisciplinary;nutrition;older adult;Older Population;Patients;Peer Review;Pennsylvania;Personal Satisfaction;Policies;policy implication;Population;Population Research;Positioning Attribute;Postdoctoral Fellow;prenatal;Production;Productivity;Psyche structure;public health relevance;Publications;Race;Relationship-Building;Research;Research Activity;Research Personnel;response;Risk;Schools;Science;Scientist;Services;Shapes;social;social culture;Social Sciences;Social support;Societies;socioeconomic development;socioeconomics;Structure;theories;Training;Underrepresented Populations;Universities;Work

PROJECT_TITLE: Center on the Demography and Economics of Aging


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Burden of Illness

PHR: Project Narrative/Public Health Relevance (Core A): Interdisciplinary, co-operative research to advance knowledge in the demography and economics of aging requires an adaptive scientific infrastructure. The Population Aging Studies Center at the University of Pennsylvania, along with this Core A, provides an intellectual platform at the crucial juncture of the behavioral, social, and health sciences. The accounting and analytic frameworks of PARC, anchored in demography and health economics, provides insights to help meet the research and evidence needs to promote successful and equitable aging for individuals, and to inform effective health policy responses in aging societies, in the U.S. as well as globally.

PI_NAMEs: KOHLER, HANS-PETER  (contact)

PROJECT_TERMS: Accounting;Aging;aging population;Applications Grants;Arts;Behavioral Sciences;CCL18 gene;Center Core Grants;Collaborations;cost effective;Decision Making;Demography;Economics;Equity;Funding;Goals;Grant;health economics;Health Policy;Health Sciences;Individual;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;Joints;Knowledge;Leadership;Light;medical schools;Mission;multidisciplinary;Pennsylvania;Postdoctoral Fellow;Process;Program Development;public health relevance;Research;Research Priority;Research Project Grants;Research Support;Resources;response;Schools;Science;Services;Social Sciences;Societies;Structure;Time;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research

PHR: Project Narrative/Public Health Relevance (Core B): Interdisciplinary, co-operative research to advance knowledge in the demography and economics of aging requires an adaptive scientific infrastructure. The Popu- lation Aging Studies Center at the University of Pennsylvania, along with this Core B, provides an intellectual platform at the crucial juncture of the behavioral, social, and health sciences. The accounting and analytic frame- works of PARC, anchored in demography and health economics, provides insights to help meet the research and evidence needs to promote successful and equitable aging for individuals, and to inform effective health policy responses in aging societies, in the U.S. as well as globally.

PROJECT_TERMS: Accounting;Address;advanced disease;Aging;aging population;aging related;Applications Grants;behavioral economics;Behavioral Sciences;Budgets;Businesses;career;CCL18 gene;Collaborations;Data Collection;data resource;Demography;Development;Economics;Educational workshop;Equity;Faculty;Feedback;Funding;Health;health economics;Health Policy;Health Sciences;Incentives;Individual;Infrastructure;innovation;insight;Institution;interdisciplinary collaboration;interest;Investments;Knowledge;Letters;medical schools;Mentorship;multidisciplinary;National Institute of Child Health and Human Development;novel;palliative;Pennsylvania;Pensions;Pilot Projects;Policies;population health;Population Study;Postdoctoral Fellow;Program Development;programs;public health relevance;Rejuvenation;Research;Resource Development;Resources;response;Retirement;Schools;Security;Social Sciences;Societies;Structure;Training;Universities;Vision;Work

PROJECT_TITLE: Core B-Program Development


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Burden of Illness;Clinical Research;Dementia;Health Services;Social Determinants of Health

PHR: Project Narrative/Public Health Relevance (Core C): Interdisciplinary, co-operative research to advance knowledge in the demography and economics of aging requires an adaptive scientific infrastructure. The Popu- lation Aging Studies Center at the University of Pennsylvania, along with this Core C, provides an intellectual platform at the crucial juncture of the behavioral, social, and health sciences. The accounting and analytic frame- works of PARC, anchored in demography and health economics, provides insights to help meet the research and evidence needs to promote successful and equitable aging for individuals, and to inform effective health policy responses in aging societies, in the U.S. as well as globally.

PROJECT_TERMS: Accounting;Address;Adult;Africa South of the Sahara;Aging;aging population;aging related;Alzheimer's disease related dementia;Area;Behavior;Behavioral Sciences;Big Data;Botswana;Brazil;Caring;CCL18 gene;Censuses;Childhood;Chile;Clinical;Cognition;cognitive testing;Collaborations;comparative;cost effectiveness;Country;Data;Data Collection;dementia care;Demography;Development;Dimensions;Economics;Educational workshop;Effectiveness of Interventions;Equity;Exhibits;Family;Family health status;France;Geographic Locations;Ghana;global health;Grant;Guatemala;Health;health economics;Health Policy;Health Sciences;Healthcare;HIV/AIDS;Hospitals;human old age (65+);Impaired cognition;improved;Individual;Infrastructure;innovation;insight;interest;intergenerational;International;Knowledge;large scale data;Latin America;Latin American;Life Cycle Stages;Link;Long-Term Care;Longitudinal Surveys;low and middle-income countries;Malawi;Medicaid;Mexico;Migrant;migration;Modeling;mortality;Nonmigrant;Nursing Homes;Older Population;outreach;Patient-Focused Outcomes;Pattern;Patterns of Care;Pennsylvania;Personal Satisfaction;Pilot Projects;Policies;Population;Protocols documentation;public health relevance;Research;Research Activity;Research Personnel;Research Project Grants;Resources;response;Role;social;social epidemiology;Social Protection;social science research;Social Sciences;Social support;Societies;Surveys;synergism;System;Technology;Testing;theories;Translating;Universities;welfare

PROJECT_TITLE: Core C. External Innovative Network Core


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Eliminating racial and ethnic disparities in costly acute care utilization among Persons With Dementia (PWD) is a national priority. By studying these patients' communities and primary care practices where they receive care from nurse practitioners in a large national study, we will produce evidence to help design future systems and community interventions to ensure optimal care for minority elderly PWD.

PI_NAMEs: POGHOSYAN, LUSINE  (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Accident and Emergency department;acute care;Address;Administrator;Affect;Alzheimer's disease related dementia;American;beneficiary;Black Populations;care delivery;Care given by nurses;care systems;Caring;Chronic Disease;Clinical;cognitive ability;Communities;community barrier;Community Healthcare;community intervention;community-level factor;Competence;Continuity of Patient Care;cost;Data;Dementia;dementia burden;dementia care;design;Disease;Disease Management;Disparity;disparity reduction;Elderly;Emergency department visit;Ensure;Environment;ethnic disparity;ethnic health disparity;ethnic minority;Ethnic Population;Face;Failure;Family;follow-up;Future;Genetic Transcription;Geographic Information Systems;health care settings;health disparity;health disparity populations;Hispanic Populations;Hospitalization;hospitalization rates;improved;Individual;innovation;Institutionalization;Intervention;Interview;Investments;Link;Measures;Mediating;Mediation;Medicare;Methods;Minority;minority communities;Minority Groups;Modeling;multilevel analysis;Nurse Practitioners;older adult;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Persons;Policies;Policy Maker;poor communities;practice factors;Prevalence;Primary Care;primary care patient;Primary Care Physician;primary care practice;primary outcome;Provider;public health intervention;Qualitative Methods;Quality of Care;racial disparity;racial health disparity;racial minority;racial population;Reminder Systems;Research Priority;Resources;response;Risk Factors;Role;Socioeconomic Factors;Survey Methodology;Surveys;System;Telephone;therapy design;Training;underserved area;Visit

PROJECT_TITLE: Care for Persons With Dementia in Nurse Practitioner Practices and Racial and Ethnic Health Disparities

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Data Science;Social Determinants of Health

PHR: Project Narrative/Public Health Relevance (Core D): Interdisciplinary, co-operative research to advance data- driven analysis in the demography and economics of aging requires significant investments in data and data security. The Population Aging Studies Center at the University of Pennsylvania, along with this Core D, provides the platform for dramatically increasing the availability and access to novel data and data linkages at the crucial juncture of the behavioral, social, and health sciences. At the same time, to speed the knowledge-transfer from social science to policy or stakeholders, Core D makes strategic investments in dissemination, expanding the skill sets of our associates as well as leveraging successful dissemination infrastructure to further PARC’s goal of informing effective health policy responses in aging societies, in the U.S. as well as globally.

PI_NAMEs: COE, NORMA B (contact)

PROJECT_TERMS: Academia;Acceleration;Address;administrative database;Aging;aging population;aging related;Area;Behavioral Sciences;Big Data;Biosocial;career;CCL18 gene;Collaborations;Communication;Complex;complex data;cost;Data;Data Linkages;data resource;Data Security;Data Sources;Demography;Discipline;Economics;Ensure;Fostering;frontier;Goals;Grant;health care economics;health economics;Health Policy;Health Sciences;Heart Research;improved;Infrastructure;innovation;Institution;Instruction;interdisciplinary approach;Interdisciplinary Study;Investigation;Investments;Joints;Knowledge;knowledgebase;Learning;Link;member;Methodology;Mission;novel;Paper;Pathway interactions;peer;Pennsylvania;Pilot Projects;Policies;Policy Maker;Population;Population Sciences;Positioning Attribute;public health relevance;Public Policy;Publications;Research;research data dissemination;Research Personnel;Resources;response;Schools;Science;skills;Social Sciences;Societies;Speed;Structure;success;Surveys;symposium;synergism;Technology;Time;Training;Translating;Universities;Work

PROJECT_TITLE: Core D. External Research Resources Support and Dissemination Core


ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative 37.9 million people worldwide currently living with HIV/AIDS rely on costly lifelong cART treatment to suppress HIV replication and are at risk of non-AIDS comorbidities as they age. Thus, there is a pressing need to develop new strategies that induce long-term remission of HIV without the need for cART. This study will test a novel strategy that harnesses the transcriptional and epigenetic programs of stem-like CD8 T cells to enhance the efficacy of immunotherapies targeting the HIV reservoir and will lay the foundation for future therapies that achieve a cure for HIV.

PI_NAMEs: YAO, CHEN  (contact)

PROGRAM_OFFICER_NAME: ZHOU, YAN

PROJECT_TERMS: Acetylation;Acute;Adopted;Adoptive Cell Transfers;Affect;Aftercare;Age;Animal Model;Animals;anti-PD-L1;antiretroviral therapy;antiviral immunity;B-Lymphocytes;BLR1 gene;cancer immunotherapy;Cancer Patient;CAR T cell therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;cell motility;Cells;Cellular Immunity;Cellular immunotherapy;Chronic;chronic infection;Clinical Research;comorbidity;cost;CRISPR screen;Cytolysis;Data;Disease remission;DNA;epigenetic drug;Epigenetic Process;epigenome;Exclusion;exhaust;exhaustion;Exhibits;Foundations;Frequencies;Future;Gene Expression Profile;Genetic Transcription;Helper-Inducer T-Lymphocyte;Histone Acetylation;Histones;HIV;HIV Infections;HIV/AIDS;Human;Immune;immune checkpoint blockade;Immune Evasion;Immunity;Immunotherapy;in vivo;infected B cell;Infection;insight;interest;Interruption;latent HIV reservoir;Lymphocytic choriomeningitis virus;Lysine;Macaca;Macaca mulatta;Malignant Neoplasms;Mediating;migration;model design;Mus;novel;novel strategies;overexpression;Pathway interactions;Patients;PD-L1 blockade;Persons;Pharmaceutical Preparations;Phenotype;Population;pre-clinical research;programs;Research;response;Risk;Sampling;Shock;Site;SIV;stem;T cell differentiation;T cell therapy;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Therapeutic Effect;therapeutic vaccine;transcription factor;transcriptome;transcriptomics;tumor;Viral;viral rebound;Viremia;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Harnessing Stem-Like CD8 T Cells for Immunotherapies to Eradicate HIV Reservoirs


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative. The proposed research is relevant to public health because it develops a novel and innovative approach to cancer surgery. The main goal is to improve tumor and margin identification, thereby increasing the safety and completeness of surgery for neuroblastoma, to ultimately improve outcomes for the most common extracranial solid tumor in children. Importantly, successful completion of this work should invigorate further research in intraoperative molecular tracer development for other adult and pediatric cancers.

PI_NAMEs: KOHANBASH, GARY ;MALEK, MARCUS M. (contact)

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: Adjuvant Therapy;Adult;Animals;Antibodies;Antigens;Architecture;cancer surgery;Cephalic;Characteristics;Childhood;Clinical;Clinical Trials;Complication;Data;Death Rate;Detection;Development;Discrimination;Disease;Drug Kinetics;Epidermal Growth Factor Receptor;Excision;Exposure to;Eye Surgeon;Face;Family suidae;FDA approved;Fluorescence;Fluorescent Antibody Technique;Goals;Hand;Head and Neck Cancer;Heterogeneity;high risk;Human Resources;Image;image guided;imaging agent;Imaging Device;imaging system;improved;improved outcome;Indocyanine Green;innovation;Label;Lesion;Location;Malignant Childhood Neoplasm;Manuals;Metastatic Neoplasm to Lymph Nodes;Modality;Modeling;Molecular;molecular imaging;Molecular Target;mouse model;near infrared dye;Near-infrared optical imaging;Neoadjuvant Therapy;Nerve;Neuroblastoma;Non-Malignant;novel;operation;Operative Surgical Procedures;Organ;Palpation;Patient-Focused Outcomes;Patients;Pediatric Neoplasm;Pentetic Acid;Performance;Perfusion;Perioperative;pre-clinical;preservation;Primary Neoplasm;Public Health;Radiation exposure;Radio;Radioisotopes;radiotracer;Rattus;Regional Disease;Research;Rodent;Safety;Sentinel Lymph Node Biopsy;Site;Solid Neoplasm;Structure;success;Surgeon;Surgical Oncology;Systemic Therapy;targeted agent;Testing;Time;Tissue Model;Tissues;tool;Tracer;Transgenic Mice;tumor;Tumor Antigens;Tumor Biology;Tumor Promotion;tumor specificity;uptake;Visual;Visualization;Work;Xenograft procedure

PROJECT_TITLE: Intraoperative dual-labeled molecular tracer to improve surgery on neuroblastoma

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Cancer immunotherapy is curing some patients who previously had extremely poor prognosis, but many patients do not respond. A critical step for immune activation is for the correct T-cells to encounter cognate tumor antigen in tumor-draining lymph nodes. We propose to analyze this process using mathematical modeling and animal experiments to determine how these encounters between antigen and T-cells are impaired in cancer. We will use our analysis to identify strategies for enhancing immune activation in non-responding patients to improve effectiveness of immunotherapy.

PI_NAMEs: MUNN, LANCE L.;PADERA, TIMOTHY P (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Affect;Anatomy;Animal Experiments;Animal Model;anti-cancer;anti-CTLA-4 therapy;anti-PD-1;anti-PD1 therapy;anti-tumor immune response;Antibodies;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Antitumor Response;Biology;Biometry;Blood Circulation;Breast Cancer Model;cancer cell;Cancer Etiology;cancer immunotherapy;cancer therapy;Cells;chemokine;Circulation;Clinical;cohort;Computer Models;Data;Data Set;Disseminated Malignant Neoplasm;draining lymph node;Drug Kinetics;Effectiveness;Epitopes;Excision;experimental study;Failure;fluid flow;Generations;Immune;immune activation;immune checkpoint;immune checkpoint blockade;immune checkpoint blockers;Immune Evasion;immune function;Immune response;Immunologist;immunoreaction;immunoregulation;Immunosuppression;Immunotherapy;Impairment;improved;improved outcome;in vivo;individual patient;insight;lymph flow;lymph nodes;Lymphatic;Lymphatic function;Lymphatic System;Lymphocyte;Lymphocyte Activation;Malignant Neoplasms;mathematical model;Measurement;Measures;Mechanics;Melanoma;Metastatic Neoplasm to Lymph Nodes;Modeling;mouse model;multi-scale modeling;multidisciplinary;Mus;Nature;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;Patients;Pattern;pharmacodynamic model;Physiological;Population;predicting response;predictive marker;prevent;Probability;Process;Prognosis;residence;response;Sampling;stem;Stochastic Processes;Systems Biology;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;trafficking;tumor;Tumor Antigens;tumor growth;Tumor Immunity;Work

PROJECT_TITLE: Systems Biology of Antigen and T-Cell Transport in Cancer Immunotherapy

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Liver Disease;Lung;Organ Transplantation;Rare Diseases;Transplantation

ORG_CITY: PHOENIX

ORG_NAME: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER

ORG_STATE: AZ

PHR: Project Narrative Based upon our novel findings that: 1) circulating exosomes released from lung transplant recipients (LTxRs) diagnosed with BOS induces epithelial mesenchymal transition of airway epithelial cells in an LKB1 dependent manner; and 2) our observed significant down regulation of LKB1 in the biopsies from LTxRs with BOS and inverse correlation with PDGFRβ. We will define the mechanism by which tumor suppressor, LKB1, participates in the development of chronic lung allograft dysfunction by determining signals leading to PDGFRβ upregulation and mechanisms leading to down regulation of LKB1. Studies proposed will employ both clinical samples from LTxRs and human airway epithelial cell culture models towards these goals.

PI_NAMEs: MOHANAKUMAR, THALACHALLOUR  (contact)

PROGRAM_OFFICER_NAME: CHARYA, ANANTH VELUGALETI

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acute;airway epithelium;Aldehydes;Allografting;Automobile Driving;Binding;Biological Markers;Biological Models;Biopsy;Bronchiolitis Obliterans;CD80 gene;CD86 gene;CDC37 gene;Cell Culture Techniques;cell growth;Cell Line;Cells;Chronic;Clinical;clinical diagnosis;Cyclic AMP-Dependent Protein Kinases;Data;Development;Diagnosis;donor-specific antibody;Down-Regulation;Early identification;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;exosome;Family;Fibrosis;Flow Cytometry;Functional disorder;Genetic Transcription;Goals;graft dysfunction;Heat-Shock Proteins 90;high risk;Human;Immunologics;In Vitro;in vitro Model;Intervention;knock-down;Liver;liver function;Lung;lung allograft;Lung Diseases;Lung Transplantation;Mediating;Mesenchymal;Metabolism;Methods;MHC Class II Genes;Modeling;Molecular;Morphology;multicatalytic endopeptidase complex;nano-string;novel;Pathogenesis;Pathology;Pathway interactions;Patients;Phosphorylation;Phosphotransferases;Plasma;Platelet-Derived Growth Factor Receptor;Play;prevent;primary endpoint;Property;Prostaglandin D2;receptor expression;Receptor Signaling;Receptor Up-Regulation;receptor upregulation;Regulation;Reporting;Risk;Risk Factors;Role;Sampling;Seasons;secondary endpoint;Signal Pathway;Signal Transduction;statistics;STK11 gene;Syndrome;Testing;Therapeutic;therapeutically effective;TNFRSF5 gene;transcription factor;Transforming Growth Factor beta;Transplant Recipients;Transplantation;Tumor Suppressor Genes;Tumor Suppressor Proteins;Up-Regulation;Viral Respiratory Tract Infection;Western Blotting

PROJECT_TITLE: Chronic Lung Allograft Dysfunction: Role for Tumor Suppressor LKB1 in Exosomes

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Neurosciences

ORG_CITY: DETROIT

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Pseudomonas aeruginosa (PA) keratitis is one of the most rapidly developing and destructive diseases of the cornea and a global cause of visual impairment and blindness. Emergence of antibiotic-resistant bacterial strains poses additional challenges for effective management of the disease and development of alternative treatment is in urgent need. This study will uncover the molecular mechanisms underlying the roles of the miR- 183/96/182 cluster (miR-183C) in PA keratitis and the protective effect of anti-miR-183C against the disease through miR-183C's regulation of corneal sensory nerve function and neuroimmune interaction in both mouse and human.

PI_NAMEs: XU, SHUNBIN  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acceleration;Address;afferent nerve;Afferent Neurons;alternative treatment;Antibacterial Response;Antibiotic Resistance;Antibiotic Therapy;Apoptosis;Bacteria;Bacterial Antibiotic Resistance;base;Biogenesis;Biological;Blindness;C57BL/6 Mouse;capsaicin receptor;Cells;Communicable Diseases;conditional knockout;Cornea;Corneal Diseases;cytotoxic;Data;density;Development;Disease;Disease Management;Disinhibition;Exhibits;Fluorescein;formyl peptide;Gene Expression;Genes;genome-wide analysis;Hour;Human;human disease;Immune;Immune response;In Vitro;in vivo;Infection;Inflammation Mediators;Inflammatory;Inflammatory Response;Injections;insight;Keratitis;knock-down;Knock-out;Knockout Mice;Knowledge;Label;Lead;Lipopolysaccharides;Mediating;Metabolic;MicroRNAs;Molecular;mouse model;Mus;Natural Immunity;Nerve;nerve supply;neurite growth;Neuroimmune;Neuropeptides;Neuropilins;neutrophil;novel;Play;prevent;Production;prophylactic;protective effect;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Publishing;receptor;Regulation;Regulator Genes;Research;resistant strain;Resolution;Role;Sensory;Severities;Severity of illness;Structure of trigeminal ganglion;Substance P;TAC1 gene;Testing;therapeutic miRNA;therapeutic target;Tissues;TLR4 gene;Topical application;transcriptome sequencing;TRPV1 gene;Untranslated RNA;Visual impairment;Wild Type Mouse

PROJECT_TITLE: The miR-183/96/182 Cluster in Pseudomonas aeruginosa-induced Keratitis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: PORTLAND

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Because both high-level noise exposure and aging may lead to cochlear deafferentation, this type of “hidden” peripheral auditory damage has the potential to affect a large number of people and have a significant influence on public health. The proposed research is relevant to the part of the NIH's mission that pertains to acquiring new knowledge to diagnose disability because it will form the basis for a clinical test battery for diagnosis of cochlear deafferentation and will clarify the perceptual impacts of this type of auditory dysfunction.

PI_NAMEs: BRAMHALL, NAOMI  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acoustic Nerve;Affect;Age;Aging;Anatomy;Animal Model;Animals;Auditory;Auditory Brainstem Responses;Auditory system;Auditory Threshold;Behavioral;Biological Markers;Biological Models;cell injury;Cell Physiology;Cochlea;Computer Models;Data;Deafferentation procedure;Development;Diagnosis;Diagnostic tests;disability;ear muscle;ganglion cell;Goals;Hearing problem;Hearing Tests;Histologic;Histology;Human;human model;human subject;Hyperacusis;Individual;individual patient;Inner Hair Cells;innovation;Knowledge;Link;man;Measurement;Measures;Methods;middle ear;Mission;Mus;noise exposure;otoacoustic emission;ototoxicity;Outer Hair Cells;Peripheral;Persons;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Physiology;Prevalence;prevent;Prevention;Public Health;Recording of previous events;Reflex action;Research;research clinical testing;response;Risk Factors;risk prediction;sound;speech in noise;Speech Perception;spiral ganglion;Stimulus;success;Synapses;Temporal bone structure;Testing;Tinnitus;tool;Translating;Translations;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Mouse, Man, and Machine: Combining Model Systems to Develop a Biomarker for Cochlear Deafferentation in Humans

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Pancreatic cancer the third deadliest cancer in the US. The KRAS oncogene is mutated in 95% of pancreatic cancers and anti-KRAS therapies are anticipated to make a significant impact on improving patient survival. I propose to develop therapies that block key ERK regulated proteins, which are critical for KRAS to drive metastatic pancreatic cancer growth.

PI_NAMEs: KLOMP, JENNIFER E (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Acute;Address;Automobile Driving;cancer cell;Cancer Etiology;cancer therapy;cell growth;Cells;Cessation of life;Clinical;clinical efficacy;Combined Modality Therapy;Complex;Computer Analysis;CRISPR library;CRISPR screen;CRISPR/Cas technology;Cytoplasm;Data;design;Development;early phase clinical trial;Ectopic Expression;effective therapy;Engineering;experimental analysis;exportin 1 protein;Failure;Genetic;genetic analysis;Goals;Growth;Growth Factor;improved;In Vitro;in vivo;inhibitor;Knowledge;KRAS2 gene;Libraries;Location;loss of function;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;MAPK1 gene;MAPK3 gene;Mass Spectrum Analysis;MEKs;Mentors;Mitogen-Activated Protein Kinase Inhibitor;Mitogen-Activated Protein Kinases;mutant;Mutate;Mutation;new therapeutic target;Normal tissue morphology;novel therapeutic intervention;Nuclear;Nuclear Export;Oncogenes;Outcome;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;pharmacologic;Phase;Phosphoproteins;phosphoproteomics;Phosphorylation;post-doctoral training;preclinical development;programs;Protein-Serine-Threonine Kinases;Proteins;Proteomics;receptor;Relapse;relapse patients;Research;research clinical testing;Research Personnel;Resistance;resistance mechanism;response;Role;Serine;Signal Transduction;Site;spatiotemporal;standard of care;success;System;targeted treatment;Therapeutic;therapeutic target;therapy development;Toxic effect;Training;Transcript;transcriptome;tumor;tumorigenesis;United States;Variant

PROJECT_TITLE: Mechanistic Basis for ERK in driving KRAS-dependent pancreatic cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Bioengineering;Cancer;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_DEPT: PHYSICS

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE Ovarian cancers have co-evolved with the patient’s immune system and build a complex tumor-immune microenvironment. As anti-PD1 immunotherapy has generally shown poor efficacy against ovarian cancers, there is a dire clinical need to complement checkpoint inhibition with treatments that stimulate infiltration or proliferation of tumor-specific TC’s. We propose an integrated experimental–mathematical oncology approach to decipher how to best harness immune sparing and immune stimulation of fractionated photoimmunotherapy to personalize treatments for advanced or recurrent epithelial ovarian cancer patients with presently dismal survival rates.

PI_NAMEs: ENDERLING, HEIKO ;SPRING, BRYAN QUILTY (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: 3-Dimensional;Abdominal Cavity;adaptive immune response;Address;alternative treatment;anti-PD-1;anti-PD1 therapy;Antibodies;Biopsy;Calibration;cancer cell;cancer infiltrating T cells;Cancer Patient;cancer therapy;Cell surface;Cells;checkpoint inhibition;Chemicals;chemotherapy;Clinical;Clinical Data;Clinical Trials;Coculture Techniques;Combined Modality Therapy;Complement;Complex;control theory;Custom;cytotoxic;Cytotoxic Chemotherapy;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Dendritic Cells;Dependence;design;Development;Disease;Distal;Dose;Dose Fractionation;dosimetry;effector T cell;Epidermal Growth Factor Receptor;Epithelial ovarian cancer;Equilibrium;Evolution;experimental study;Fluorescence;Foundations;Fractionation;Funding;Goals;Greater sac of peritoneum;Head and Neck Cancer;Image;image guided;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immunity;Immunocompetent;immunogenic cell death;Immunologic Stimulation;Immunologics;Immunooncology;immunoregulation;Immunotherapy;improved;in silico;In Vitro;in vivo;in vivo imaging;individualized medicine;Infiltration;innovation;Intestines;Light;Link;Malignant neoplasm of lung;Malignant neoplasm of ovary;mathematical methods;mathematical model;Mathematics;Measures;microendoscopy;Modality;Modeling;Molecular;Molecular Target;Monitor;mouse model;neoplastic cell;Newly Diagnosed;novel;Oncology;Operative Surgical Procedures;Outcome;Paclitaxel;Pathologic;Patient-Focused Outcomes;Patients;personalized medicine;Phase II Clinical Trials;Photochemistry;photoimmunotherapy;Photosensitizing Agents;Phototherapy;Phototoxicity;physical science;pre-clinical;preservation;Proliferating;prospective;Protocols documentation;PUVA Photochemotherapy;Recurrence;Regimen;responders and non-responders;response;simulation;Site;Skin Cancer;Survival Rate;T-Lymphocyte;Testing;Therapeutic;three dimensional cell culture;Time;time use;Training;treatment response;tumor;Tumor Debulking;Tumor Immunity;tumor-immune system interactions;Tumor-infiltrating immune cells;Validation

PROJECT_TITLE: Fractionated photoimmunotherapy to harness low-dose immunostimulation in ovarian cancer


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Hearing Loss;Neurosciences;Pediatric;Prevention;Rehabilitation

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE The proposed project maps out the developmental trajectories of spatial hearing abilities in complex reverberant environments for school-age children with normal hearing. Findings of this work will provide intervention benchmarks to guide the fitting of bilateral hearing devices (e.g., cochlear implants and hearing aids) for children with hearing loss.

PI_NAMEs: PENG, ZHAO ELLEN (contact)

PROJECT_TERMS: 12 year old;18 year old;5 year old;9 year old;Address;Adult;Affect;Age;Area;Auditory;Auditory Perception;auditory processing;Benchmarking;Bilateral;Binaural;Child;Cochlear Implants;Communication;Complex;Cueing for speech;Cues;Data;Development;Devices;educational atmosphere;Environment;Foundations;Goals;Hearing;Hearing Aids;hearing impairment;Hearing Tests;Image;Impairment;improved;innovation;Intervention;Knowledge;Learning;Life;Maps;Measures;National Institute on Deafness and Other Communication Disorders;noise perception;normal hearing;novel;object perception;Outcome;Outcome Measure;Pattern;Perception;Performance;precedence effect;prevent;Process;Psychophysics;Role;school environment;School-Age Population;Severities;Signal Transduction;Size Perception;skills;Social Interaction;sound;Source;Speech;speech in noise;Speech Perception;Surface;Testing;Time;virtual;virtual reality;Width;Work

PROJECT_TITLE: DEVELOPMENT OF FUNCTIONAL SPATIAL HEARING IN REVERBERATION

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Depression;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: TUCSON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: NARRATIVE Parkinson’s disease (PD) is a prevalent neurodegenerative disease characterized by a hypokinetic movement disorder with symptoms of tremor, rigidity, and bradykinesia. The most common treatment for PD consists of dopamine replacement therapy utilizing either the dopamine precursor levodopa (L-DOPA) or dopamine receptor agonists. These therapies become unsatisfactory as the disease progresses due to a variety of short- term and long-term side effects that occur with dose escalation, including levodopa-induced dyskinesias (LID); therefore, there is an urgent need to develop non-dopaminergic therapies.

PI_NAMEs: FALK, TORSTEN  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: abnormal involuntary movement;Action Potentials;Acute;Affect;Anesthetics;Animal Model;Animals;antagonist;Area;awake;Basal Ganglia;behavior measurement;bench to bedside;bench-to-bedside translation;Bradykinesia;Brain;Brain-Derived Neurotrophic Factor;Case Study;Cells;Chemicals;chronic pain;Clinical Data;Clinical Trials;common treatment;comorbid depression;Controlled Clinical Trials;Corpus striatum structure;Data;Deep Brain Stimulation;Dendritic Spines;density;Development;Disease;disease model;Dopamine;Dopamine Agonists;dopamine replacement therapy;Dose;drug candidate;Drug Targeting;Dyskinetic syndrome;Foundations;FRAP1 gene;Future;Generations;Hour;Implanted Electrodes;Infusion procedures;Injections;interest;Interneurons;Involuntary Movements;Ketamine;Knowledge;L-DOPA induced dyskinesia;Levodopa;Locomotion;Long-Term Effects;Measures;meetings;Mental Depression;Migraine;MK801;Modeling;Molecular;Morphology;Motor Cortex;Movement;Movement Disorders;multidisciplinary;N-Methyl-D-Aspartate Receptors;neural;Neurodegenerative Disorders;Neuronal Plasticity;Neurons;neuroprotection;novel;Opioid;Opioid agonist;Opioid Receptor;Oxidopamine;Pain;pain reduction;Parkinson Disease;Pathologic;Pathway interactions;Patients;Persons;Phase I Clinical Trials;Post-Traumatic Stress Disorders;pre-clinical;Psychiatry;Publications;Rattus;receptor;Research Personnel;Science;Severities;sex;side effect;Signal Transduction;Symptomatic Parkinsonism;Symptoms;Synapses;System;Testing;Therapeutic;Therapeutic Effect;Time;treatment-resistant depression;Tremor;United States;Vertebral column;Walking;Work

PROJECT_TITLE: Mechanisms of Low-Dose Ketamine Treatment for Parkinson's Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Asthma;Chronic Obstructive Pulmonary Disease;Infectious Diseases;Lung;Microbiome

ORG_DEPT: PEDIATRICS

PHR: Project narrative: Commensal fungi have emerged as an important player in the regulation of lung immunity and diseases, yet the mechanism(s) of the gut mycobiota (fungal community) directing gut-lung immune crosstalk has not been elucidated so far. Here, we propose to investigate the role of antifungal T cell response to gut fungi in airway inflammation that affects estimated millions of Americans. Understanding the role of gut mycobiota on the outcome of pulmonary disease and dissecting the mechanism(s) behind mycobiota-mediated lung immune regulation.

PI_NAMEs: LI, XIN  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Adrenal Cortex Hormones;Affect;Airway Disease;airway inflammation;allergic airway disease;allergic airway inflammation;Allergic Bronchopulmonary Aspergillosis;Alternaria;American;anti-fungal agents;Antibiotics;antigen-specific T cells;Aspergillus fumigatus;Asthma;asthmatic;asthmatic patient;Award;Candida;Candida albicans;career;Career Mobility;CD4 Positive T Lymphocytes;Cells;Cellular biology;Childhood Asthma;Chronic;Chronic Obstructive Pulmonary Disease;Cladosporium;Communities;cross reactivity;Cystic Fibrosis;Development;Disease;Dissection;dysbiosis;Fungal Antigens;fungal microbiota;fungus;Gnotobiotic;Goals;Growth;gut microbiome;gut microbiota;gut-lung axis;Health;high risk;Human;Immune;Immune response;Immune System Diseases;Immunity;Immunologic Factors;Immunology;immunoregulation;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Bowel Diseases;Inhalation;insight;Intestines;Investigation;Knowledge;Lung;Lung Diseases;Mediating;Mentors;Mentorship;microbial community;microbiome alteration;migration;Modeling;Molecular;Mononuclear;Mucous Membrane;Mus;Neonatal;novel therapeutics;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Persons;Phagocytes;Process;Pulmonary Inflammation;Pulmonary Pathology;Regulation;Research;Research Personnel;Role;Shapes;skill acquisition;standard of care;T cell response;T-Cell Activation;T-Lymphocyte;Technical Expertise;Training;transcriptomics

PROJECT_TITLE: Mechanistic Investigation of Gut Mycobiota in the Regulation of Lung Immunity and Disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: This application is focused on understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2), the causal agent of coronavirus disease 2019 (COVID-19), enters cells. Using unbiased genetic and optical tracking approaches we will interrogate the host factors that are used during entry and where the virus gains access to the cell. We will define where and how therapeutics that are in late stage clinical development including monoclonal antibodies, soluble receptor decoys, and small molecule inhibitors interrupt viral entry.

PI_NAMEs: KIRCHHAUSEN, TOMAS ;WHELAN, SEAN PJ (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Antibodies;Biochemical;Biological;Cathepsins;Cell membrane;Cell model;Cell Physiology;Cell surface;cell type;Cells;cellular imaging;Chemicals;Chimera organism;Clinical;clinical development;Clinical Trials;Complement;Core Protein;Coronavirus;Coupled;COVID-19;CRISPR screen;Data;Dependence;Endosomes;Escape Mutant;Exhibits;experimental study;Fluorescence Microscopy;functional outcomes;Gene Modified;Genes;Genetic;Genetic Screening;genome-wide;Glycoproteins;Goals;Heparitin Sulfate;Human;Image;imaging approach;Individual;Infection;Integration Host Factors;Integrins;Interruption;loss of function;Maps;Mediating;Membrane;Membrane Fusion;Microscopy;Molecular;Monoclonal Antibodies;Mus;mutant;Neuropilins;NRP1 gene;Optics;particle;Pathway interactions;Peptide Hydrolases;Peptidyl-Dipeptidase A;Phosphoproteins;Process;Productivity;Proteins;Proteolysis;Reagent;receptor;receptor binding;Ribonucleoproteins;Route;Sampling;SARS coronavirus;SARS-CoV-2 entry inhibitor;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 spike protein;Serine Protease;Sialic Acids;small molecule;small molecule inhibitor;targeted treatment;Therapeutic;Therapeutic Intervention;Therapeutic Uses;tissue tropism;TMPRSS2 gene;tool;trafficking;uptake;Vesicular stomatitis Indiana virus;Viral;Virion;Virus;Virus Diseases;Work

PROJECT_TITLE: Mechanism and Inhibition of SARS-CoV-2 Entry

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

PHR: 8. Project Narrative The need for well-trained cancer biologists is more acute than ever with the growing impact of cancer on life and health. In this renewal application for our long-standing interdisciplinary Cancer Cell Biology Training Program for predoctoral students at the University of North Carolina at Chapel Hill, we propose our vision for the training of cancer biologists who will be well prepared to contribute rigorously and effectively to the changing landscape of cancer biology, whether their future paths are in academic or non-academic careers.

PI_NAMEs: COX, ADRIENNE D;DER, CHANNING J. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: cancer cell;Cellular biology;Training Programs

PROJECT_TITLE: Cancer Cell Biology Training Program

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Telehealth

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Pharmacies are nationally emerging as frontline public health practicing spaces due to their ubiquity, accessibility to medication and screening, and rapid scalability. Moreover, independent pharmacies are often located in under-resourced areas where corporate chains are typically absent, are ideal for public health interventions to reduce disparities (as previously evidenced), are more flexible, and can therefore be rapidly scaled up. Based on two decades of disparities-focused pharmacy-based intervention research, our team will investigate in-pharmacy delivery of opioid use disorder services (i.e., low-threshold access to telemedicine-based buprenorphine treatment initiation, naloxone dispensation/overdose prevention counseling) and HIV services access (i.e., HIV testing/ counseling, PrEP/PEP dispensation, HIV treatment re/initiation) among persons who use opioids.

PI_NAMEs: LEKAS, HELEN-MARIA ;LEWIS, CRYSTAL FULLER (contact);TOFIGHI, BABAK

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Administrator;AIDS prevention;Area;Attitude;authority;Black race;Buprenorphine;buprenorphine treatment;Caring;Clinic;Clinical;Communities;community based service;community burden;community organizations;community partnership;Community Services;cost;Counseling;COVID-19;Data;design;Development;Disparity;disparity reduction;Electronic Health Record;experience;flexibility;Focus Groups;Food;Fostering;Goals;Guidelines;Harm Reduction;Health;health disparity;health inequalities;Healthcare Systems;HIV;Hospitals;Housing;Human immunodeficiency virus test;Infrastructure;innovation;Insurance;Intervention;Intervention Studies;Interview;Latinx;Legal;Link;Low income;medical schools;Mind;naloxone dispensing;New York City;opioid mortality;opioid overdose;opioid use disorder;opioid user;overdose death;overdose prevention;Participant;patient navigation;Persons;Pharmaceutical Preparations;Pharmaceutical Services;Pharmacists;Pharmacy facility;Positioning Attribute;pre-exposure prophylaxis;Privacy;Provider;Public Assistance;Public Health;public health intervention;Public Health Practice;Recording of previous events;recruit;Research;Resources;SARS-CoV-2 exposure;scale up;screening;Services;Shelter facility;Site;social health determinants;Social Work;Structure;substance use treatment;Support Groups;Surveys;Syringes;System;Tablet Computer;Tablets;Telemedicine;Telephone;Testing;Training;United States Public Health Service;usability;Vaccination;video visit;virtual

PROJECT_TITLE: Feasibility of pharmacy-delivered patient navigation + virtual buprenorphine + HIV services

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: NORTHRIDGE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

PHR: Project Narrative The stress from cultural mismatch negatively disrupts overall wellness including health (self- reported mental/physical distress) and academics and may be directly linked to biological and clinical markers of health. Thus, there is a dire need to understand fundamental knowledge and mechanisms underlying cultural mismatch to inform interventions, programs and policies that can ensure health and educational equity for all. Cultural mismatch likely influences health in a variety of contexts or groups; thus, results from this work can aid in enhancing the health of society as a whole.

PI_NAMEs: VASQUEZ-SALGADO, YOLANDA  (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Administrator;Back;Biological;Biological Markers;Body mass index;Clinical assessments;Clinical Markers;cohort;college;Communities;community college;comparative;Data;Distress;Education;Educational process of instructing;Enrollment;Ensure;Equity;ethnic diversity;Ethnic Population;expectation;experience;Faculty;Family;First Generation College Students;graduate student;Health;health assessment;Hispanic;Hispanic-serving Institution;Holistic Health;Home;Hydrocortisone;improved;Individual;information gathering;Institution;Intervention;Interview;Investigation;Knowledge;Latinx;Learning;Letters;Link;Measures;Mental Health;Modeling;novel;open source;Outcome;Patient Self-Report;Pattern;peer;physical conditioning;Physiological;Play;Policies;Process;programs;Psyche structure;racial population;Reporting;Research;resilience;resilience factor;Role;Site;Societies;Source;Stress;Students;Surveys;theories;Time;Transcript;Universities;university student;Work

PROJECT_TITLE: Investigating Cultural Mismatch and its Associations to Health and Academic Outcomes Among Latinx Students During the Transition to College: The Moderating Role of Education Context and Resilience


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Digestive Diseases;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative We will study the impact of high and chronic pesticide exposures in a rural environment on the gut microbiome of Parkinson’s disease (PD) patients, their household members and healthy community controls and its contributions to progression of PD. This research will be highly efficient due to our access to an existing cohort of PD patients and unaffected community controls - who live in a heavily agriculturally pesticide exposed area of California – and a network of rural health care providers. Our research may discovery novel etiological pathways for pesticide action through the microbiome, propose interventions to prevent PD progression, and change public policy and pesticide regulations.

PI_NAMEs: RITZ, BEATE R. (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Address;Affect;Age;agricultural pesticide;Air Pollution;alpha synuclein;Animals;Area;Assessment tool;Behavior;Biological;Biological Models;Blood;Blood specimen;Brain;Brain Pathology;California;Chronic;Clinical;Clinical Data;Cognitive;cohort;Communities;Constipation;Cross-Sectional Studies;Data;Development;Diet;Digestive System Disorders;Disease;disease diagnosis;Disease Progression;Elderly;Enrollment;Enteric Nervous System;Environment;Environmental Exposure;Environmental Impact;Environmental Risk Factor;Etiology;experience;experimental study;Exposure to;Feces;follow-up;Funding;gastrointestinal;gastrointestinal symptom;Gastroparesis;gene environment interaction;Genes;Genetic;Geographic Information Systems;gut inflammation;gut microbiome;gut microbiota;gut-brain axis;Health Personnel;Household;Human;Human Microbiome;human microbiota;Immune system;Impaired cognition;Inflammation;insight;Intervention;Lewy Bodies;Life Style;Longitudinal Studies;Measures;Mediating;Medical;member;Metabolic Pathway;metabolomics;metagenome;Metagenomics;Metals;Microbe;microbiome;microbiome composition;microbiome research;microbiota;Motility;Motor;motor impairment;Nerve Degeneration;Nervous System Physiology;Neurodegenerative Disorders;non-motor symptom;novel;Nutrient;Onset of illness;Parkinson Disease;parkinson's disease registry;Participant;Pathologic;Pathway interactions;Patients;pesticide exposure;pesticide interaction;Pesticides;Pharmaceutical Preparations;Phenotype;Physiology;Play;Population;Population Study;prevent;Prevention;Process;protein aggregation;Public Policy;Records;recruit;Regulation;Reporting;Research;Resources;RNA, Ribosomal, 16S;Role;rural environment;rural health network;Serum;sex;Shotguns;Specificity;stool sample;Susceptibility Gene;System;Testing;Time;time use;tool;Toxin;uptake

PROJECT_TITLE: Microbiome, Environment, and Parkinsons disease (MEP) PESTICIDE EXPOSURES AND THE GUT MICROBIOME IN PARKINSONS DISEASE

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE The reprogramming of differentiated cells to induced pluripotent stem cells represents a remarkable reconfiguration of gene regulatory programs and provides the unprecedented ability to generate any type of human cell in unlimited amounts for therapeutic purposes and drug screening. The goal of this project is to identify the general principle regarding transcription factors remodeling cellular networks that define human cell identities. The results of this project will further reveal how human genetic variation affects the establishment and maintenance of the induced stem cell state.

PI_NAMEs: LUO, CHONGYUAN  (contact);PLATH, KATHRIN ;ZAITLEN, NOAH A

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Affect;Alleles;Architecture;ATAC-seq;Binding;Biological;Biological Assay;c-myc Genes;Candidate Disease Gene;causal variant;Cell Differentiation process;Cell Line;Cell Nucleus;Cell Reprogramming;cell type;Cells;Cellular Morphology;ChIP-seq;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Computer Models;Consensus;CRISPR interference;Cytosine;Data;Data Set;disease model;DNA Methylation;Drug Screening;embryonic stem cell;Enhancers;epigenome;epigenomics;Event;experimental study;Fibroblasts;Gene Expression;Gene Expression Regulation;gene interaction;gene regulatory network;Genes;Genetic;Genetic Engineering;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome sequencing;genomic data;Genomics;Goals;Heterogeneity;histone modification;Human;Human Genetics;Human Genome;human induced pluripotent stem cells;In Situ;Individual;induced pluripotent stem cell;innovation;insight;Joints;Knowledge;Maintenance;Maps;Measurement;Mediating;Methods;Methylation;Modeling;Molecular;Molecular Conformation;molecular phenotype;Mouse Strains;Multiomic Data;multiple omics;Nature;novel;Patients;Phenotype;pluripotency;Population;Population Genetics;predictive modeling;Process;programs;Quantitative Trait Loci;Regenerative Medicine;Regulation;Regulatory Element;repaired;Repression;Resolution;Resources;RNA;RNA methylation;Role;Series;single cell ATAC-seq;single-cell RNA sequencing;Site;Somatic Cell;Specificity;Statistical Methods;stem cells;System;Technology;Testing;Therapeutic;Time;transcription factor;transcriptional reprogramming;transcriptome;transcriptomic profiling;transcriptomics;Untranslated RNA;Variant;whole genome;Work

PROJECT_TITLE: Leveraging genetic variation to dissect gene regulatory networks of reprogramming to pluripotency


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative High-risk Acute Myeloid Leukemia and Myelodysplastic Syndrome are aggressive hematologic cancers associated with a very poor prognosis, with less than 20% of patients surviving beyond 1 year. Venetoclax, a BCL-2 inhibitor is one of the most exciting drugs in AML therapy. In this project we designed a Phase II clinical trial combining venetoclax with an optimized 10-day decitabine regimen in unfavorable risk categories of AML and MDS, with goals to improve outcomes of these patients by accelerating molecular responses and to further characterize molecular determinants of response and resistance.

PI_NAMEs: KONOPLEVA, MARINA Y (contact);SPENCER, DAVID H

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Acceleration;Acute Myelocytic Leukemia;acute myeloid leukemia cell;antileukemic activity;Apoptosis;Apoptotic;aspirate;Azacitidine;BCL1 Oncogene;BCL2L1 gene;Bone Marrow;Categories;Cells;Clinical;clinically significant;cohort;Combined Modality Therapy;Cytogenetics;Data;Decitabine;Dependence;design;Disease;Dysmyelopoietic Syndromes;Elderly;Enrollment;exome;exome sequencing;Family;Family member;Functional dependence;Futility;Future;Goals;Hematologic Neoplasms;Hematology;Hemodilution;high risk;improved;improved outcome;inhibitor;Institution;leukemia;leukemia treatment;Leukemic Cell;leukemic stem cell;Mass Spectrum Analysis;MCL1 gene;Molecular;Molecular Analysis;Monitor;Morphology;Mutate;Mutation;novel;novel strategies;older patient;open label;Outcome;patient response;Patient-Focused Outcomes;Patients;Pattern;peripheral blood;Pharmaceutical Preparations;phase 2 study;Phase II Clinical Trials;phase II trial;Prognosis;Prognostic Marker;Protein Family;Proteins;Protocols documentation;Randomized;Recovery;Refractory;Refractory Disease;Regimen;Relapse;Resistance;resistance mechanism;response;Risk;Safety;Sampling;Schedule;small molecule inhibitor;Source;stem cell population;Stem cell transplant;Subgroup;Surrogate Endpoint;Survival Rate;Testing;Therapeutic;Toxic effect;TP53 gene;Treatment-related toxicity;Variant

PROJECT_TITLE: Targeting apoptosis in high-risk AML and MDS with BCL-2 inhibitor Venetoclax and optimized 10-day Decitabine regimen

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Genetics;Human Genome;Microbiome

PHR: PROJECT NARRATIVE While many studies have performed analyses to define the ocular surface microbiome composition, there remain gaps in knowledge in regard to microbiome stability, the influence of factors like age, sex, and geographic location on microbiome make-up, and whether bacteria at the ocular surface are true ocular surface colonizers. This proposal is designed to increase resolution and confidence in determining bacteria that are true colonizers of the eye by revealing bacteria that are present at the ocular surface longitudinally and testing whether those bacteria stimulate human immune cells and/or can be introduced to and re-isolated from the ocular surface of mice.

PI_NAMEs: GALOR, ANAT ;ST LEGER, ANTHONY J (contact)

PROJECT_TERMS: Address;Age;Animal Model;Bacteria;Bacterial DNA;base;Biomass;Cells;Clinical;Collection;Communities;Contact Lenses;cost;cytokine;Data;Data Set;design;Development;Disease;DNA;DNA sequencing;Equilibrium;examination questions;experience;Eye;Eye diseases;fecal transplantation;Flow Cytometry;Foundations;Future;geographic difference;Geographic Locations;Geography;germ free condition;Germ-Free;Gnotobiotic;Goals;gut microbiome;Health;host microbiome;Human;human subject;Immune;Immune response;Immune system;Immunity;Immunologic Stimulation;Immunology;In Vitro;in vivo;Incubated;Individual;Infection;Infectious Agent;Integration Host Factors;Interdisciplinary Study;Knowledge;Laboratories;Link;longitudinal analysis;Measures;member;metagenomic sequencing;Microbe;Microbiology;microbiome;microbiome analysis;microbiome components;microbiome composition;microbiome research;microbiome sequencing;microbiome signature;Modeling;Molecular;Monitor;mouse model;Mus;Nature;next generation sequencing;ocular microbiome;ocular surface;ocular surface disease;Ophthalmology;Organism;Pathology;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Physiological;Physiology;Positioning Attribute;Predisposition;Process;Production;programs;Proliferating;Protocols documentation;recruit;repository;Research;Resolution;Resources;response;RNA analysis;Role;sex;Site;Swab;Symptoms;System;Techniques;Testing;Time;transcriptome sequencing;Ulcerative Colitis

PROJECT_TITLE: Defining bacterial members of the ocular surface microbiome and assessing stability over time


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunization;Immunotherapy;Nanotechnology;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE In complex diseases like cancer, a single-adjuvant vaccine may not be fully effective to mitigate the myriad immunosuppressive effects of a heterogeneous aggressive tumor microenvironment such as that of triple- negative breast cancer. Co-delivery of multiple adjuvants in a rationally designed “super adjuvant” formulation can harness multiple pattern recognition receptor pathways simultaneously to drive a proinflammatory synergistic cytokine response that has both breadth and depth. Here we propose to design a tumor-targeted “super adjuvant” immunomodulatory nanoparticle platform for in situ cancer vaccination that coencapsulates 3 synergistic innate agonists of the STING, TLR4, and TLR9 pathways to promote Type I interferon-mediated anti-tumor immunity.

PI_NAMEs: ATUKORALE, PRABHANI  (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: 4T1;Address;Adjuvant;Agonist;anti-cancer research;Antigen-Presenting Cells;Antigens;Automobile Driving;Biomedical Engineering;Blood Circulation;Blood Vessels;Cancer Biology;cancer type;Cell Line;cell type;Cells;Chemicals;Communicable Diseases;Complex;cytokine;Cytokine Signaling;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Deposition;design;Development;Diameter;Disease;DNA;Encapsulated;Endothelial Cells;engineering design;Epidermal Growth Factor Receptor;ethylene glycol;Fibrin;Fibrinogen;Formulation;Genetic Engineering;Harvest;Heterogeneity;high risk;Homing;Immune;Immune response;immunogenic;Immunologic Memory;Immunology;immunoregulation;Immunosuppression;In Situ;in situ cancer vaccination;in situ vaccination;In Vitro;in vivo;Inflammatory;Injections;innovation;Integrins;Interferon Type I;IRF3 gene;Kinetics;Knowledge;Lipid A;Lipids;lymph nodes;Macrophage;Malignant Neoplasms;Mediating;melting;Methods;Microfluidics;mouse model;nanoparticle;nanoscale;neoantigens;neoplastic cell;P-Selectin;Pathway interactions;Patients;Pattern recognition receptor;Periodicity;Production;Publications;Qualifying;rational design;response;Role;Safety;Scheme;Stimulator of Interferon Genes;surface coating;synergism;T cell response;technology platform;Temperature;Testing;TLR4 gene;Toxic effect;transcription factor;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;uptake;Vaccination;Vaccines;Virus

PROJECT_TITLE: Designing a targeted 'super adjuvant' nanoparticle platform for vaccination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE To help end the HIV epidemic, we will develop a new surveillance approach that will obtain early warning signs of outbreaks among people who inject drugs (PWID) in San Francisco and Alameda counties, California. A cohort of 600 PWID will be recruited from the community using outreach and peer referral. Each month, PWID will report on their experiences by smart phone or in-person interviews, including risk and preventive behaviors, use of services, and other events significant to the HIV and drug use epidemics in the US.

PI_NAMEs: MCFARLAND, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: SHARP, GERALD B

PROJECT_TERMS: Adherence;African American;African American population;Awareness;Back;Baseline Surveys;Behavior;Black race;California;Caring;Cellular Phone;Cessation of life;Cities;cohort;Communities;County;Data;Data Collection;Disease Outbreaks;Drug usage;Ecological momentary assessment;Enrollment;Epidemic;epidemiologic data;Epidemiology;epidemiology study;Equipment and supply inventories;Event;experience;harm reduction programs;health disparity;high risk;HIV;HIV diagnosis;HIV Infections;HIV risk;Home;Homelessness;Human immunodeficiency virus test;Hybrids;Infection;Injecting drug user;Intervention;Interview;marginalization;men who have sex with men;Methods;novel;opioid overdose;Outcome;outreach;Overdose;overdose prevention;Participant;Pattern;peer;Persons;Population;pre-exposure prophylaxis;Prevalence;Prevention;Prevention program;Preventive;Questionnaires;recruit;Reporting;response;Risk;Risk Behaviors;Rotation;Sample Size;San Francisco;Sentinel;Sentinel Surveillance;Services;Signal Transduction;Societies;starfish sampling;substance use;success;surveillance data;System;Technology;Time;Time trend;transmission process;uptake

PROJECT_TITLE: Brief Longitudinal Incident Sentinel Surveillance (BLISS) to End the HIV Epidemic among Persons Who Inject Drugs (PWID)


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: This project will determine whether the newly discovered optic nerve laminar region- Neural progenitor cells (ONLR-NPCs) directly protect retinal ganglion cells (RGCs) from axonal ischemic stress, whether their loss increases RGC stress, and whether they partially effect their neuroprotective action through secreted extracellular vesicles. We will use a mouse transgenic model enabling selective ONLR-NPC depletion, the rodent model of non-arteritic anterior ischemic optic neuropathy (rNAION) in both mice and rats, and cell culture techniques, evaluating the effects of ONLR-NPC loss on RGC stress and loss, and determining whether direct administration of ONLR-NPC extracellular vesicles improve outcomes and begin identifying their components. Our findings will identify the factors that contribute to RGC stress and disease resistance and generate new, improved approaches to treatment of optic nerve diseases.

PI_NAMEs: BERNSTEIN, STEVEN L (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Acceleration;Acute;Age;age related;Aging;aging process;Anterior;Anterior Ischemic Optic Neuropathy;Apoptosis;Astrocytes;Axon;axonopathy;Biological;biomarker panel;Blindness;Blood Vessels;Cell Culture Techniques;Cell Death;Cell secretion;Cell Survival;Cells;Cellular Stress;Cessation of life;Communication;Coupling;deep sequencing;Defect;Disease;Disease Resistance;Dissection;Dissociation;Distal;effective therapy;enhancing factor;exosome;extracellular vesicles;Eye;Ganciclovir;Glaucoma;Growth;Growth Factor;Health;Human;improved;improved outcome;in vivo;Individual;injury recovery;innovation;Ischemia;Ischemic Optic Neuropathy;Mediating;Membrane;MicroRNAs;Modeling;Molecular;Mus;myelination;nanovesicle;Natural regeneration;nerve stem cell;nestin protein;neuroprotection;Neurosphere;nonhuman primate;Nuclear Pore Complex;old mice;Optic Disk;Optic Nerve;optic nerve disorder;Patients;Phagocytes;Physiologic Intraocular Pressure;postnatal;Predisposition;Prevalence;Primary Open Angle Glaucoma;Property;Proteins;Rattus;Resistance;Retina;Retinal Ganglion Cells;retinal stimulation;Rodent;Rodent Model;Role;stem cell biomarkers;stem cell niche;stem cells;Stress;stress reduction;Supporting Cell;Techniques;Thinking;Thymidine Kinase;Transgenic Mice;Transgenic Model;Vesicle;Vision

PROJECT_TITLE: The role of optic nerve lamina region stem cells in age-related optic nerve disease


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: COLLEGE OF STATEN ISLAND

PHR: The project will advance the understanding of fundamental regulatory mechanisms that control embryonic development in a relatively simple invertebrate model system with favorable experimental advantages. This project is relevant to human and animal health because the basic mechanisms that control their embryonic processes are similar. Therefore, this project will facilitate the identification of therapeutic strategies relevant to modern medicine, particularly in the field of regenerative medicine.

PI_NAMEs: ARENAS-MENA, CESAR  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Adult;Animals;ATAC-seq;Base Pairing;Base Sequence;Binding;Binding Sites;Biological Models;Biology;blastocyst;career;Cell Differentiation process;cell type;Cells;Chromatin;chromatin remodeling;Cleavage Under Targets and Release Using Nuclease;Conserved Sequence;Data Set;Deoxyribonuclease I;design;Detection;detection method;Development;Developmental Gene;DNA;DNA Sequence;doctoral student;Economics;Educational process of instructing;Embryo;Embryonic Development;Enhancers;Evolution;experimental study;Future;Gene Expression Regulation;gene regulatory network;Genes;Genetic Transcription;Genome;genome-wide;genomic profiles;Genomics;Goals;graduate student;Health;High-Throughput Nucleotide Sequencing;Histone H3.3;Histones;Human;Institution;Invertebrates;Lytechinus variegatus;Mentors;Methods;Micrococcal Nuclease;Modeling;Modern Medicine;mRNA Expression;mutant;Mutation;New York City;novel;nuclease;Nucleosomes;Phagocytes;Population;Precision Run-On Sequencing;predictive tools;Prevalence;Process;promoter;Property;recruit;Recruitment Activity;Regenerative Medicine;Regulator Genes;Regulatory Element;Research;Resolution;Role;Scientific Advances and Accomplishments;Sea Urchins;social;Social Mobility;student participation;Students;synergism;Testing;Therapeutic;tissue regeneration;tissue repair;Training;transcription factor;trend;undergraduate research experience;undergraduate student;Underrepresented Students;Universities;Variant;vector;XCL1 gene

PROJECT_TITLE: Transcriptional potency in early embryos

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-C (81)]


ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Inhibitory receptors, like PD1, CTLA4 and LAG3, are overexpressed in chronic viral infections and cancer, preventing disease clearance, and are thus now major immunotherapeutic targets in the treatment of cancer. However, we still have a very limited understanding of how LAG3, the most recent inhibitory receptor to be targeted in the clinic, works. A greater understanding of the LAG3 mechanism of action may lead to the development of optimal antagonists for the treatment of chronic viral infections and cancer, and agonists for the treatment of autoimmune and inflammatory diseases.

PI_NAMEs: MARIUZZA, ROY A;VIGNALI, DARIO AA (contact);WORKMAN, CREG J

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Address;Agonist;antagonist;anti-PD-1;Antibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;Binding;Biological Assay;Biological Models;Biological Process;biophysical analysis;Biophysics;Bispecific Antibodies;cancer therapy;CD3 Antigens;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cell surface;Chronic;Clinic;Clinical;combinatorial;Cryoelectron Microscopy;CTLA4 gene;Cytoplasmic Tail;design;Development;dimer;Dimerization;Disease;exhaust;FDA approved;Fibrinogen;Goals;Hand;Hepatocyte;Human;Immune;Immunity;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Inflammatory;insight;Knowledge;Libraries;Ligands;Maps;Mediating;Melanoma patient;Metastatic Melanoma;MHC Class II Genes;Microscopy;Monoclonal Antibodies;monomer;mouse model;Mus;mutant;overexpression;particle;Phase;Phylogenetic Analysis;Play;Positioning Attribute;prevent;programmed cell death protein 1;Progression-Free Survivals;Protein Secretion;Proteins;randomized trial;rational design;receptor;Research;Role;Signal Transduction;Site;Structure;System;T cell therapy;T-Lymphocyte;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Monoclonal Antibodies;therapeutically effective;Tissues;tool;tumor;ultra high resolution;Viral Cancer;Virus Diseases;Work

PROJECT_TITLE: Structure, Function and Mechanistic Analysis of LAG3

STUDY_SECTION: TIO

STUDY_SECTION_NAME: Translational Immuno-oncology Study Section[TIO]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Dietary Supplements;Headaches;Migraine;Natural Products;Neurosciences;Nutrition;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: SPRINGFIELD

ORG_NAME: MISSOURI STATE UNIVERSITY

PHR: Program Director/Principal Investigator (Last, First, Middle): Durham, Paul, Louis NARRATIVE We have shown that dietary supplementation of a polyphenol-enriched grape seed extract inhibits expression of proteins implicated in chronic pain and enhances descending pain modulation pathways activated by opioids and cannabinoids. Our goal is to better understand the cellular and molecular changes within the nervous system mediated by grape seed extract to further validate its use as a safe and effective nutraceutical in a complementary and integrated therapeutic approach for chronic pain.

PI_NAMEs: DURHAM, PAUL L (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Academic Research Enhancement Awards;Adenylate Cyclase;Agonist;antagonist;Astrocytes;Baclofen;Binding;Biological Markers;Calcitonin Gene-Related Peptide;Calcitonin-Gene Related Peptide Receptor;Cannabinoids;Central Nervous System;central sensitization;Chronic;chronic pain;chronic pain management;Communication;Coupled;Couples;Coupling;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Development;dietary;Dietary Supplementation;Endocannabinoids;endogenous opioids;Enzymes;Foundations;Future;glial activation;Glial Fibrillary Acidic Protein;Glutamates;Goals;Grant;grape seed extract;Image;immunocytochemistry;In Vitro;in vivo;Inflammatory;inhibitor;insight;Institution;Ion Channel;Ions;Maintenance;Mediating;Medicine;Messenger RNA;Microglia;Migraine;Mitogen-Activated Protein Kinases;Molecular;Molecular Target;Muscle satellite cell;National Center for Complementary and Integrative Health;Nervous System;Neurogenic Inflammation;Neuroglia;Neurons;Nociception;NOS2A gene;novel;novel therapeutic intervention;Nutraceutical;Opioid;Orofacial Pain;p38 Mitogen Activated Protein Kinase;Pain;pain signal;Pathology;Pathway interactions;Patients;Peripheral;Peripheral Nervous System;Pharmacologic Substance;Physiological;polyphenol;Pre-Clinical Model;Principal Investigator;Procedures;programs;protein expression;Proteins;Publishing;RAMP1;receptor;Receptor Inhibition;Reporting;response;Role;Schwann Cells;Signal Transduction;Spinal Cord;Structure of trigeminal ganglion;Structure of trigeminal nerve spinal tract nucleus;Symptoms;Techniques;Temporomandibular Joint Disorders;Testing;Therapeutic;therapeutically effective;transcriptome sequencing;Trigeminal Pain;Trigeminal System;undergraduate student;United States National Institutes of Health;Western Blotting

PROJECT_TITLE: Grape Seed Extract Modulation of Peripheral and Central Nervous System Neuron-Glia Interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (04)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: BATON ROUGE

ORG_DEPT: CHEMISTRY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: PROJECT NARRATIVE This research investigates protein phase separation, a fundamental process underlying the formation of biomolecular condensates that are crucial for cellular functions and associated with age-related disorders. The study employs a model protein and polymer system as surrogates for proteins and nucleic acids, both are common precursors for biomolecular condensates. By examining the effects of a wide range of crowding agents commonly used to simulate the crowded environment within living cells, this study aims at elucidating the effects of crowding on the conformation and intermolecular interactions of protein and polymer molecules, and to establish connections between the molecular-level information and the bulk phase behavior of proteins. Collectively, our research will provide a comprehensive, molecular-level understanding of protein phase behavior in cell-like environments, thereby advancing the fields of biophysics and cellular biology, and opening new avenues for therapeutic development in diseases related to abnormal protein phase separation.

PI_NAMEs: XU, AMY  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;Affect;age-related disease;Antibodies;Behavior;Biological Process;biological research;biomacromolecule;biophysical properties;Biophysics;cell age;Cell Physiology;Cell Volumes;Cells;Cellular biology;chemical property;Complex;Crowding;Crows;Disease;Disease Progression;Disparity;Environment;Excipients;Formulation;Goals;Individual;intermolecular interaction;Investigation;Link;Liquid substance;Measures;Methods;Modeling;Molecular;Molecular Conformation;Nature;Neutrons;novel;Nucleic Acids;Phase;Phase Transition;Physical condensation;physical property;Play;Polymers;Process;Property;protein function;protein protein interaction;Proteins;Research;Research Personnel;Roentgen Rays;Role;Sampling;Series;Sucrose;System;Techniques;Testing;Therapeutic;therapeutic development

PROJECT_TITLE: Phase behavior of proteins in crowded environments

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


PHR: NARRATIVE Parkinson’s disease (PD) is a prevalent neurodegenerative disease characterized by a hypokinetic movement disorder with symptoms of tremor, rigidity, and bradykinesia. The most common treatment for PD consists of dopamine replacement therapy utilizing either the dopamine precursor levodopa (L-DOPA) or dopamine receptor agonists. These therapies become unsatisfactory as the disease progresses due to a variety of short- term and long-term side effects that occur with dose escalation, including levodopa-induced dyskinesias (LID); therefore, there is an urgent need to develop non-dopaminergic therapies.

PI_NAMEs: FALK, TORSTEN  (contact)

PROJECT_TERMS: abnormal involuntary movement;Action Potentials;Acute;Affect;Anesthetics;Animal Model;Animals;antagonist;Area;awake;Basal Ganglia;behavior measurement;bench to bedside;bench-to-bedside translation;Bradykinesia;Brain;Brain-Derived Neurotrophic Factor;Case Study;Cells;Chemicals;chronic pain;Clinical Data;Clinical Trials;common treatment;comorbid depression;Controlled Clinical Trials;Corpus striatum structure;Data;Deep Brain Stimulation;Dendritic Spines;density;Development;Disease;disease model;Dopamine;Dopamine Agonists;dopamine replacement therapy;Dose;drug candidate;Drug Targeting;Dyskinetic syndrome;Foundations;FRAP1 gene;Future;Generations;Hour;Implanted Electrodes;Infusion procedures;Injections;interest;Interneurons;Involuntary Movements;Ketamine;Knowledge;L-DOPA induced dyskinesia;Levodopa;Locomotion;Long-Term Effects;Measures;meetings;Mental Depression;Migraine;MK801;Modeling;Molecular;Morphology;Motor Cortex;Movement;Movement Disorders;multidisciplinary;N-Methyl-D-Aspartate Receptors;neural;Neurodegenerative Disorders;Neuronal Plasticity;Neurons;neuroprotection;novel;Opioid;Opioid agonist;Opioid Receptor;Oxidopamine;Pain;pain reduction;Parkinson Disease;Pathologic;Pathway interactions;Patients;Persons;Phase I Clinical Trials;Post-Traumatic Stress Disorders;pre-clinical;Psychiatry;Publications;Rattus;receptor;Research Personnel;Science;Severities;sex;side effect;Signal Transduction;Symptomatic Parkinsonism;Symptoms;Synapses;System;Testing;Therapeutic;Therapeutic Effect;Time;treatment-resistant depression;Tremor;United States;Vertebral column;Walking;Work

PROJECT_TITLE: Mechanisms of Low-Dose Ketamine Treatment for Parkinson's Disease