NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: HOFFMAN, DAX A (contact)

PROJECT_TERMS: Action Potentials;Adaptive Behaviors;Address;Affect;age related;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease patient;Amyloid beta-Protein;Angelman Syndrome;antagonist;Area;autism spectrum disorder;Automobile Driving;Behavior;behavior test;behavioral impairment;Binding;Binding Proteins;Brain;Brain region;cell type;Central Nervous System;Central Nervous System Diseases;Chromosomes;Cognitive;cognitive enhancement;comparison control;Complex;Data;Dementia;Dendrites;Development;Dipeptidyl Peptidases;Electroencephalography;Electrophysiology (science);Emotions;Epilepsy;Exhibits;experience;Fire - disasters;flexibility;Follow-Up Studies;Fragile X Syndrome;Frequencies;Genes;Glutamate Receptor;High Prevalence;high risk;hippocampal pyramidal neuron;Hippocampus;Homosynaptic Depression;Human;Impairment;imprint;improved;Individual;information processing;Intellectual functioning disability;Ion Channel;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Kv4.2 channel;learned behavior;Learning;Link;Locomotion;long term memory;Long-Term Potentiation;loss of function;Mediating;Memory;Metabotropic Glutamate Receptors;Molecular;morris water maze;mouse model;Mus;mutant;Mutation;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Neurodevelopmental Disorder;neuroinflammation;neuron development;neuronal circuitry;neuronal excitability;Neurons;novel;p38 Mitogen Activated Protein Kinase;patch clamp;Pathology;Pathway interactions;Persons;pharmacologic;Phenotype;Phosphorylation;Phosphorylation Site;Physiologic pulse;Population;postsynaptic neurons;Potassium;Potassium Channel;preservation;Presynaptic Terminals;prevent;Process;Property;Proteins;Purkinje Cells;Pyramidal Cells;Receptor Signaling;Regulation;Research;Reversal Learning;Role;Scaffolding Protein;Seizures;Site;Sleep disturbances;Structure;Surface;Synapses;Synaptic plasticity;Synaptic Transmission;tau Proteins;Telemetry;Testing;Therapeutic;trafficking;Training;UBE3A gene;Ubiquitination;Vertebral column;voltage gated channel;Voltage-Gated Potassium Channel;Wild Type Mouse;X-linked intellectual disability

PROJECT_TITLE: Potassium Channels and Dendritic Function in Hippocampal Pyramidal Neurons


ACTIVITY: ZIA

ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cancer;Genetics;Natural Products

PI_NAMEs: SACKETT, DAN L (contact)

PROJECT_TERMS: Adopted;Affinity;alpha Tubulin;Anti-Inflammatory Agents;Antiparasitic Agents;benzimidazole;beta Tubulin;Binding;Binding Sites;Biochemical;Biological Assay;Biology;Biophysics;Blood;Blood Cells;blood treatment;Bone Marrow;Brain;cancer cell;Cells;Cellular biology;Cellular Morphology;Chemistry;chemotherapy;Chickens;Cilia;Clinical;Clinical Medicine;Code;Colchicine;Collaborations;combinatorial;copolymer;Cryoelectron Microscopy;Curiosities;Cytoplasm;Cytoskeleton;Development;dimer;Disease;Drug Interactions;Drug resistance;Drug Targeting;Drug usage;Elements;Erythrocytes;Familial hypophosphatemic bone disease;Fanconi Syndrome;Fluorescence;Genes;Genetic Predisposition to Disease;Genome;Growth;Guanosine Triphosphate Phosphohydrolases;hearing impairment;Hematopoietic Neoplasms;HIV;Human;Hyperopia;improved;insight;katanin;Kidney;Knowledge;Learning;Ligands;Macrolides;Malignant Neoplasms;marine natural product;Measures;Mediating;Medicine;Microtubule Stabilization;Microtubules;Mitosis;Mitotic spindle;Modeling;Molecular Conformation;Movement;Mutation;National Human Genome Research Institute;Natural Products;novel therapeutics;Organism;Paclitaxel;Parasites;Parents;Patients;Peptides;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;physical property;Polymers;Post-Translational Protein Processing;preclinical development;programs;Property;protein aminoacid sequence;Protein Subunits;Proteins;Rattus;Recycling;Regulation;Reporting;Research;residence;resistance mechanism;Retina;rev Protein;Role;Site;small molecule;Solid Neoplasm;stoichiometry;Structure;Surface;Tail;Testing;Therapeutic;Time;Tissues;trafficking;Tubular formation;Tubulin;tumor;Work

PROJECT_TITLE: Microtubule regulation by isotype expression, post translational modification, and by small molecules.


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PI_NAMEs: CLARK, DAVID J (contact)

PROJECT_TERMS: access restrictions;Address;Adenine;Affect;Affinity;AT Rich Sequence;ATAC-seq;attenuation;autism spectrum disorder;base;Binding Sites;Biological Models;Biology;Cell Nucleus;Cells;Centromere;CHD1 gene;Childhood;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Code;Complex;Data;density;Detection;Disease;DNA;DNA Methylation;DNA Sequence;DNA-Binding Proteins;Ensure;Enzymes;Epigenetic Process;Euchromatin;Eukaryotic Cell;Event;Excision;experimental study;Freezing;Gene Activation;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Genome;genome-wide;Genomic DNA;Heterochromatin;Heterogeneity;high throughput technology;Histones;HMGN Proteins;Human;Human Cell Line;human disease;in vivo;Individual;ISWI;Link;M.SssI;Malignant Neoplasms;Manuscripts;Maps;Mating Types;Measurement;Measures;Methods;Methylation;methylation pattern;Methyltransferase;Micrococcal nuclease digestion of chromatin followed by sequencing;Modeling;Modification;Molecular Biology;Molecular Conformation;Movement;Mutate;Mutation;nanopore;Nature;new technology;novel;Nucleic Acids;Nucleosomes;Organism;Output;Paper;Pharmaceutical Preparations;Physical condensation;Play;Population;Positioning Attribute;prevent;Probability;promoter;Property;Publications;Publishing;recruit;Repression;Research;Resolution;response;Rhabdoid Tumor;RNA Polymerase II;Role;Running;Saccharomycetales;Sequence-Specific DNA Binding Protein;Signal Transduction;Site;Slide;Statistical Models;structural biology;Structure;SWI/SNF Family Complex;System;Techniques;Testing;Transcript;transcription factor;Transcription Initiation Site;whole genome;wound;yeast genome;Yeasts

PROJECT_TITLE: Chromatin Remodeling and Gene Activation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Mental Health;Neurosciences;Schizophrenia

PI_NAMEs: BURGESS, HAROLD  (contact)

PROJECT_TERMS: Acoustics;Architecture;Area;Atlases;Auditory;Behavior;Behavior Control;behavior test;Behavioral;Behavioral Mechanisms;behavioral response;Biological Models;Brain;Brain region;brain shape;Brain Stem;causal variant;cell type;Cells;Clinical;Collaborations;Complex;Computer Analysis;Cues;design;Development;Disease;disease model;Embryo;Etiology;Exhibits;Gene Expression;Genes;Genetic;genetic analysis;genetic approach;genetic manipulation;Genetic Models;Glutamate Receptor;Goals;Health;Hormones;Human;Image;in vivo;Individual;insight;Laboratories;Larva;Lesion;Link;Mammals;Maps;Mediating;Modeling;Molecular;morphometry;neural;neural circuit;Neuroanatomy;Neurobiology;Neurodevelopmental Disorder;Neurologic;neuromechanism;neuronal circuitry;Neurons;novel;Optics;optogenetics;Output;Pathology;Pathway interactions;Patients;Pattern;Physiologic pulse;Post-Traumatic Stress Disorders;prepulse inhibition;Process;Research Personnel;Resolution;response;Role;Sampling;Scanning;Schizophrenia;screening;Sensory;Signal Transduction;single cell sequencing;Startle Reaction;Stimulus;Stress;Structure;Techniques;Tegmentum Mesencephali;Tonic Immobility Response;tool;transcriptome;Transgenic Organisms;Visual;Visualization;Zebrafish

PROJECT_TITLE: Neuronal Circuits Controlling Behavior: Genetic Analysis in Zebrafish


NIH_SPENDING_CATS: Biotechnology;Genetics

PI_NAMEs: HINNEBUSCH, ALAN G (contact)

PROJECT_TERMS: Acetylation;Amino Acids;ATP phosphohydrolase;Automobile Driving;Binding;Binding Proteins;Binding Sites;Categories;Cell Nucleus;Cells;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Code;cofactor;Complex;Consensus;Coupled;Defect;defined contribution;DNA;EAF1 gene;Elements;Event;Gene Activation;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Genome;genome-wide;histone acetyltransferase;Histone H2A;Histones;Impairment;in vivo;Intercistronic Region;interest;Length;Mediating;Mediator;Messenger RNA;Modeling;Molecular Chaperones;Mutation;Mutation Analysis;Nucleosomes;Pathway interactions;Polymerase;Positioning Attribute;Process;promoter;Promoter Regions;recruit;Regulation;Reporter;Reporting;Ribosomal Proteins;RNA Polymerase II;Role;Saccharomycetales;SAGA;scaffold;Starvation;SUPT3H gene;SWI/SNF Family Complex;TAF1 gene;TATA-Box Binding Protein;Technology;Testing;Transcript;transcription factor;Transcription Initiation Site;Transcriptional Activation;Transcriptional Regulation;transcriptome;Work;Yeasts

PROJECT_TITLE: Transcriptional Regulation of Gene Expression


PI_NAMEs: LEVIN, HENRY L. (contact)

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Affect;Cell Fraction;Cell Line;Cells;Clinical Trials;Code;Conflict (Psychology);Cultured Cells;design;Development;DNA;DNA Polymerase II;DNA Transposable Elements;Elements;endonuclease;Engineering;experimental study;Fluorescence;Frequencies;Future;gene therapy;Genetic;Genetic Diseases;Genome;Genomics;Hela Cells;Human Genome;in vitro Assay;Individual;Integration Host Factors;Introns;L1 Elements;Length;Long Interspersed Elements;Measures;Messenger RNA;Microscopy;model organism;Molecular;Mutagenesis;Mutation;Outcome;Pharmacologic Substance;Positioning Attribute;preservation;prevent;promoter;red fluorescent protein;Reporter;Reporter Genes;Retrotransposon;Reverse Transcription;RNA;RNA Splicing;RNA-Binding Proteins;RNA-Directed DNA Polymerase;Role;Site;System;Technology;Therapeutic;tool;Translations;vector;Visualization

PROJECT_TITLE: Development and application of transposable element technology


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Suicide

PI_NAMEs: GILMAN, STEPHEN  (contact)

PROJECT_TERMS: 7 year old;Address;Adolescence;Adult;Age;Area;Attention;autism spectrum disorder;Beginning of Life;Behavior;Behavioral;Behavioral Sciences;Biogenesis;Biological;Biological Markers;Blood;Cessation of life;Child;Child Development;Child Health;Child health equity;Childhood;Cognitive;cognitive process;cohort;completed suicide;Data;design;Development;Disadvantaged;Disease;Disparity;disparity reduction;early childhood;Economically Deprived Population;Education;emerging adulthood;Enrollment;Environment;ethnic disparity;ethnic minority;Ethnic Population;Etiology;Event;Exposure to;Face;Family;fetal;Foundations;Future;Generations;Genetic Code;Health;Health behavior;health disparity;Human Development;Immune;Immunologic Markers;Impairment;improved;indexing;Individual;Inflammation;insight;intergenerational;Intervention;Knowledge;Language;Life;Life course epidemiology;Life Cycle Stages;Life Expectancy;lifetime risk;Link;Longitudinal cohort study;Major Depressive Disorder;maternal serum;Measurement;Measures;member;Mental Health;Modality;Morbidity - disease rate;Mothers;National Institute of Child Health and Human Development;Neighborhoods;Nested Case-Control Study;Neurocognitive;Neurologic;Neurological outcome;neuropsychiatric disorder;next generation;offspring;Participant;Pathway interactions;Perinatal;Personal Satisfaction;Phenotype;Physical environment;Physiology;Population;population health;Population Heterogeneity;Pregnancy;Premature Mortality;prenatal;prenatal exposure;Prevention;Primary Prevention;Psychopathology;racial disparity;racial minority;racial population;Readiness;Research;resilience;Rhode Island;Risk;Risk Factors;Role;Schizophrenia;Schools;Shapes;social;social determinants;Social Environment;Social Sciences;socioeconomic disadvantage;socioeconomic disparity;socioeconomics;success;Suicide;suicide mortality;Time Study;transmission process;United States;Work

PROJECT_TITLE: Social determinants of child development and mental health


NIH_SPENDING_CATS: Batten Disease;Brain Disorders;Clinical Research;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

PI_NAMEs: DANG DO, AN  (contact)

PROJECT_TERMS: Address;Affect;Apoptosis;Apoptotic;Attenuated;Autophagocytosis;Basic Science;Behavioral;biobank;biological adaptation to stress;Blindness;Blood;Brain;cell growth regulation;Cell Line;Cell Survival;Cells;Cellular Stress;Chemicals;Childhood;Clinical;CLN3 gene;cohort;Collaborations;Complex;Development;developmental disease;Disaccharides;Disease;Drosophila genus;emerging adult;Emotional;Endoplasmic Reticulum;Epilepsy;exome sequencing;experience;Experimental Models;Exposure to;family support;Fibroblasts;fly;Foundations;Genes;Goals;GRP78 gene;Guanine Nucleotides;Human;human disease;Hypogonadism;improved;Individual;induced pluripotent stem cell;infancy;Intellectual functioning disability;Intervention Trial;Investigation;Laboratories;Life Expectancy;Link;lipopigments;Literature;Lysosomal Storage Diseases;Lysosomes;male;MEHMO syndrome;Messenger RNA;Microcephaly;Modeling;motor disorder;mouse model;mRNA Translation;Mutant Strains Mice;Natural History;Nerve Degeneration;Nervous System Disorder;Obesity;Online Mendelian Inheritance In Man;Oxidative Stress;pain sensitivity;Pathology;Pathway interactions;Peptide Initiation Factors;Pharmacologic Substance;Phenotype;Phosphorylation;Phosphotransferases;Process;programs;prospective;Proteins;Psyche structure;Reagent;Regulation;Reporting;Research;Research Personnel;response;Role;Seizures;Stress;Therapeutic;Therapeutic Trials;Transcription Coactivator;transcription factor;Translation Initiation;translational research program;Translations;Trehalose;Tunicamycin;Urine;Variant;Weight;Work

PROJECT_TITLE: Research Investigations of Cellular Stress in Development and Diseases


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PI_NAMEs: TATSI, CHRISTINA  (contact)

PROJECT_TERMS: 21 year old;adenoma;Adolescent;Area;Biochemical;biomarker identification;Caring;Child;Childhood;Clinical;Cushing Syndrome;Data;Diagnosis;Disease;disease diagnosis;Disease remission;Early treatment;Eligibility Determination;Evaluation;Functional disorder;Future;General Population;Genetic;Gigantism;Glucocorticoids;Growth Hormone Secreting Pituitary Adenoma;Hormone secretion;Hormones;hypercortisolemia;Hypothalamic Diseases;Image;Investigation;Knowledge;Laboratories;Lesion;Long-Term Effects;Modeling;Morbidity - disease rate;novel therapeutic intervention;novel therapeutics;Patients;pegvisomant;Phenotype;Pituitary Corticotropin Secreting Adenoma;Pituitary Diseases;Pituitary Neoplasms;Pituitary-dependent Cushing's disease;Population;potential biomarker;Prevention;Prognosis;Protocols documentation;Publications;Rare Diseases;Research;research study;Residual state;Resistance;Risk Factors;safety study;Somatotrophin increased;Somatotropin;Survivors;Therapeutic;tumor

PROJECT_TITLE: Evaluation of Hypothalamic and Pituitary Disorders


ACTIVITY: ZIC

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences;Rare Diseases

PI_NAMEs: DALE, RYAN  (contact)

PROJECT_TERMS: Affect;algorithm development;Axon;Bacterial Genes;Bacterial RNA;Binding Proteins;Bioinformatics;Biological Assay;Biological Models;Biology;Borrelia;Brain;Cell Line;cell type;Cells;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;clinically relevant;cluster computing;Collection;Communities;Complex;Computer Analysis;Computer software;Consult;Custom;Data;Data Analyses;Detection;Development;differential expression;Embryo;Enhancers;Ensure;Escherichia coli;Event;Exercise;Experimental Designs;experimental study;extracellular vesicles;Feedback;Future;Gene Expression Regulation;Genes;Genetic Recombination;Genetic Transcription;genome-wide analysis;genomic data;Genomics;Germ-Line Mutation;High Performance Computing;High-Throughput Nucleotide Sequencing;HIV;Human;Human Genome;improved;Infrastructure;International;Laboratories;Lymphatic;Manuscripts;Messenger RNA;metabolomics;Microfluidic Microchips;MicroRNAs;Modeling;Moths;mouse model;Mouse Strains;multiple omics;Mus;mutant;Mutation;National Institute of Child Health and Human Development;Nerve Regeneration;neuron development;Neurons;novel;Nuclear Pore Complex Proteins;optogenetics;Osteogenesis Imperfecta;Palate;Pathway interactions;Patients;Phenotype;Pituitary Neoplasms;Pituitary-dependent Cushing's disease;Preparation;Process;Proteins;Proteomics;Protocols documentation;Quality Control;Rare Diseases;Regulation;Reporting;Reproducibility;Research;Research Personnel;Ribosomal RNA;RNA;Role;Running;Sampling;single cell ATAC-seq;single cell sequencing;single nucleus RNA-sequencing;single-cell RNA sequencing;skills;Small RNA;software development;Software Tools;Subcellular structure;Syndrome;System;Thyroid Hormone Receptor;Tissues;tool;tool development;Tooth structure;Training;Transcript;transcriptome sequencing;transcriptomics;Transfer RNA;transposon sequencing;United States National Institutes of Health;Untranslated RNA;Validation;Variant;Visualization;web app;Xenopus;Yeasts;Zebrafish

PROJECT_TITLE: NICHD Bioinformatics and Scientific Programming Core


ACTIVITY: ZIG

PI_NAMEs: LABITT, RACHAEL  (contact)

PROJECT_TERMS: access restrictions;Advisory Committees;Ambulatory Care;animal care;Animal Care and Use Committees;Animal Experimentation;animal facility;Animal Husbandry;animal model selection;Animals;Behavioral Research;Caring;Certification;comparative;Consultations;Country;Dedications;design;Disease;Ethics;Formulation;germ free condition;Guidelines;Health;Health Status;high standard;Housing;Human;Institution;interest;International;Intramural Research Program;Laboratory Animal Production and Facilities;Laboratory Animals;Lead;Medicine;Monitor;National Human Genome Research Institute;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Child Health and Human Development;Neurosciences Research;Office of Administrative Management;Pathogenicity;Policies;prevent;Procedures;Process;programs;Quarantine;Regulation;Research;Research Activity;Research Personnel;research study;Research Support;Rodent;success;Therapeutic;United States National Institutes of Health;Xenopus;Zebrafish

PROJECT_TITLE: Research Animal Management Branch


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: IOWA CITY

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PI_NAMEs: WINOKUR, PATRICIA  (contact)

PROJECT_TERMS: Area;Biological;Biological Products;Bioterrorism;Clinical;Communicable Diseases;Contracts;Development;Educational workshop;efficacy testing;Emerging Communicable Diseases;Evaluation;evaluation/testing;Feasibility Studies;immunogenicity;Immunology procedure;Investigational New Drug Application;Licensing;novel vaccines;Office of Administrative Management;Parasites;Phase;product development;protocol development;Qualifying;Reporting;Safety;Sampling;Services;Site Visit;Testing;testing services;therapeutic evaluation;Therapeutic Trials;Toxicology;Training;Trichocephalus trichiura;vaccine candidate;Vaccines;Validation

PROJECT_TITLE: Vaccine and Treatment Evaluation Units (VTEU) Protocol Development and Implementation for a Phase II Therapeutic Trial for Trichuris Trichiura


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PI_NAMEs: FORTUNE, SARAH  (contact)

PROJECT_TERMS: Animal Model;Animals;cohort;Computer Models;Goals;HIV;Human;Immune;Immune Evasion;Immune response;Immune Targeting;Immunity;Immunologics;improved;multidisciplinary;Mus;Mycobacterium Infections;Mycobacterium tuberculosis;non-tuberculosis mycobacteria;nonhuman primate;programs;Research Activity;Research Personnel;response;Sampling;SIV;Technology;Testing;Tissues;Translating;Tuberculosis;Tuberculosis Vaccines;vaccine strategy

PROJECT_TITLE: IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_CITY: FAIRFAX

ORG_NAME: BLACK CANYON CONSULTING LLC

ORG_STATE: VA

PI_NAMEs: ESSER, HALEY  (contact)

PROJECT_TERMS: clinical development;Dependovirus;gene therapy;Lead;National Center for Advancing Translational Sciences;Office Management;programs;Resources;United States National Institutes of Health

PROJECT_TITLE: NATIONAL INSTITUTE OF HEALTH (NIH), NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES (NCATS), BESPOKE GENE THERAPY CONSORTIUM - COORDINATION CENTER


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: MALVERN

ORG_NAME: VENATORX PHARMACEUTICALS, INC.

ORG_STATE: PA

PI_NAMEs: D OLIVEIRA, C FERNANDO  (contact)

PROJECT_TERMS: Advanced Development;Antibiotic Resistance;Bacterial Drug Resistance;bacterial resistance;biodefense;candidate selection;Chemistry;Clinical assessments;Combating Antibiotic Resistant Bacteria;Communicable Diseases;efficacy evaluation;Emerging Communicable Diseases;lead optimization;manufacture;pathogen;pre-clinical;product development;research and development;Research Support;safety assessment;Therapeutic;therapeutic candidate;therapeutic development

PROJECT_TITLE: Development of Therapeutic Products for Biodefense and Emerging Antibiotic-Resistant Infectious Diseases


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: HENKEL, TIMOTHY  (contact)


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: Criminal justice involvement and recidivism are highly prevalent among Veterans and important social determinants of health. Few treatment options with demonstrated effectiveness are available for Justice- Involved Veterans (JIVs). New comprehensive treatments such as Maintaining Independence and Sobriety Through Systems Integration, Outreach, and Networking-Criminal Justice Edition (MISSION-CJ) are emerging and aim to reduce criminal recidivism, improve treatment access and engagement and address other health- related risk factors underlying recidivism (i.e., substance use, mental health, housing, and employment problems). This study will be run in Mental Health Residential Rehabilitation Treatment Programs, and intends to compare MISSION-CJ versus Enhanced Usual Care, the latter of which includes a structured peer support curriculum as well as community outreach and linkage support. The long-term goal is to help the VA reduce criminal recidivism among JIVs, and improve the long-term health of this vulnerable Veteran population.

PI_NAMEs: BLONIGEN, DANIEL MICHAEL;SMELSON, DAVID A (contact)

PROJECT_TERMS: Acceleration;addiction;Address;Admission activity;Adoption;anti social;antisocial behavior;Attitude;Behavior;behavioral health;Caring;Case Manager;Charge;Chronic;Cognition;Communities;community based care;Community Integration;Community Outreach;community reintegration;Community Services;Continuity of Patient Care;Criminal Justice;Disease;disparity reduction;Education;Educational Curriculum;Effectiveness;effectiveness testing;Elements;Employment;Enrollment;Equipment and supply inventories;Evidence based treatment;follow-up;formative assessment;Future;future implementation;Goals;handbook;Health;health equity;Health Services Accessibility;Homeless persons;Homelessness;Housing;hybrid type 1 design;Hybrids;implementation trial;Imprisonment;improved;Individual;innovation;Intervention;Interview;Justice;Knowledge;Learning;Legal;Legal system;Link;Manuals;Measures;Mediating;Mental Health;Mental Health Court;Mental Health Services;Methodology;military veteran;Mission;Modeling;Monitor;Needs Assessment;novel;Outcome;outreach;peer;peer support;Personal Satisfaction;Population;prevent;programs;Provider;psychosocial;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recidivism;Rehabilitation therapy;Research;Resources;Risk;Risk Assessment;Risk Factors;Running;service delivery;service engagement;service gap;Services;Site;sobriety;social cognition;social health determinants;Specialist;Standardization;Structure;Subgroup;substance use;Substance Use Disorder;Suicide prevention;Supervision;System;Systems Integration;tool;Trauma;treatment as usual;treatment planning;treatment program;Unemployment;Veterans;Work

PROJECT_TITLE: A Randomized Controlled Trial of MISSION-CJ for Justice-Involved Homeless Veterans with Co-Occurring Substance Use and Mental Health

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: JACKSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: With PPO prevalence rising, it's crucial to uncover the early mechanisms of renal disease that increase CKD risk in adulthood. This proposal utilizes the SSLepRmutant rat to study how alterations in energy metabolism in PT contribute to early renal injury in PPO. The research aims to identify how IR affects PT glucose metabolism during renal injury and evaluate interventions to reduce IR, thus improving PT function and clinical outcomes for obese children with renal disease.

PI_NAMEs: WILLIAMS, JAN MICHAEL (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Adult;adult obesity;Affect;Animals;Attention;Cells;Characteristics;Child;Childhood;Childhood Injury;Chronic Kidney Failure;Clinical;Clinical Research;Data;Development;Diabetes Mellitus;diabetic;Energy Metabolism;Energy-Generating Resources;Epidemic;Event;Experimental Designs;fatty acid oxidation;Feedback;Future;Gluconeogenesis;Gluconeogenesis Inhibition;Glucose;glucose metabolism;glucose output;glucose production;glucose transport;Glucose Transporter;Glycolysis;Goals;Health;Hyperglycemia;hypertensive;Immune;Impairment;improved;Incidence;Inflammation;inhibitor;Injury;Injury to Kidney;Insulin;Insulin Resistance;Intervention;Kidney;Kidney Diseases;leptin receptor;Mass Spectrum Analysis;Metabolic Diseases;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;mutant;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity in children;Outcome;Pathway interactions;Patients;Physiological;Play;prepuberty;Prevalence;prevent;Proteinuria;Proteomics;Proximal Kidney Tubules;Rattus;Reporting;Research;response;Risk;Risk Factors;Role;salt sensitive;SLC2A1 gene;Sodium;symporter;Testing;Thinness;Tubular formation;United States

PROJECT_TITLE: Insulin and Immune Mechanisms in Obesity-Induced Renal Disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Neurosciences;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PI_NAMEs: SCHMALJOHN, CONNIE  (contact)

PROJECT_TERMS: 2019-nCoV;Aerosols;Alveolus;Animal Disease Models;Animals;Artificial Intelligence;biodefense;Brain;brain magnetic resonance imaging;Cavia;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Containment;COVID-19;COVID-19 treatment;Data;Data Analyses;Democratic Republic of the Congo;Deposition;Development;Diagnostic;Disease;Dose;Drug Screening;Ebola virus;efficacy clinical trial;Emerging Communicable Diseases;Environment;Equipment;Evaluation;Exposure to;functional group;Genomics;Government;Guinea;guinea pig model;Hamsters;Human;human disease;Image;imaging capabilities;Immune;improved;In Vitro;in vivo;in vivo Model;industry partner;Infection;Infectious Diseases Research;Interdisciplinary Study;Intraperitoneal Injections;Intravenous Immunoglobulins;Laboratories;Lassa virus;Lead;Liberia;Life;Lung;Magnetic Resonance Imaging;Medical Imaging;Methods;Mission;Modeling;Monkeypox;Morphology;MRI Scans;National Institute of Allergy and Infectious Disease;National Security;Nipah Virus;nonhuman primate;novel;optical imaging;Organ;Organoids;Play;Positioning Attribute;Positron-Emission Tomography;pre-clinical;preclinical imaging;prevent;Process;process improvement;protective efficacy;Protocols documentation;randomized, clinical trials;Regulation;Reporter;Research;research facility;research study;Research Support;Resources;Rodent;Role;SARS-CoV-2 infection;SARS-CoV-2 variant;Series;Signal Transduction;single cell sequencing;Site;small molecule therapeutics;System;Testing;Therapeutic antibodies;tool;Training;transcriptome;transcriptomics;Transgenic Mice;United States National Institutes of Health;Vaccines;Viral;Virulent;Virus;Virus Diseases

PROJECT_TITLE: Integrated Research Facility at Fort Detrick


ACTIVITY: ZID

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Hematology;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Primary Immunodeficiencies;Rare Diseases;Vaccine Related;Vaccine Related - AIDS;Vector-Borne Diseases

PI_NAMEs: TIERNEY, JOHN  (contact)

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;Antibodies;Area;Aspirin;Atopic Dermatitis;Benchmarking;Biological;Blood;Chronic Granulomatous Disease;Clinical;clinical center;Clinical Research;Clinical Trials;Coagulation Process;Coccidioidomycosis;Collaborations;Common Variable Immunodeficiency;Communicable Diseases;Communication;congenital immunodeficiency;Country;COVID-19;Cysticercosis;Data;Deficiency Diseases;Democratic Republic of the Congo;Dengue;Devices;Disease;Disease Outbreaks;Disseminated eosinophilic collagen disease;Ebola;Elements;Emerging Communicable Diseases;Eosinophilia;follow-up;Formulation;GATA2 deficiency;Genetic Markers;Goals;Health Personnel;Hepatitis;HIV;Hyper-IgE Syndrome;IgE;Immune;immune function;immune reconstitution;Immune system;immunodeficiency;Immunologic Deficiency Syndromes;Indonesia;Infection;Infectious Diseases Research;Inflammatory;Influenza;International;international center;Intramural Research Program;Investigational Drugs;Leukocyte Adhesion Deficiency;liver injury;Lyme Disease;Lymphopenia;Malaria;Measures;Medical;Modeling;Monitoring Clinical Trials;Monkeypox;Mycobacterium Infections;Mycoses;National Institute of Allergy and Infectious Disease;non-tuberculous mycobacterial infection;Occupations;operation;Participant;Persons;Policies;Predisposition;Process;Program Development;programs;protocol development;recurrent infection;Refractory;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Respiratory syncytial virus;response;Safety;Services;Site;success;Syndrome;System;Therapeutic Studies;Time;Tissues;Training and Education;Tuberculosis;United States National Institutes of Health;Universities;Vaccines;Virus Replication;Work;ZIKA

PROJECT_TITLE: Regulatory Support Services


ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: The recent and ongoing outbreak of SARS-CoV-2 highlights the need for a streamlined approach to develop effective antivirals; there are no vaccines or approved antivirals. We propose to apply our established strategies for developing viral-entry preventing peptides to develop SARS-CoV-2 peptide antivirals based on viral genetic information; based on our previous findings we have high confidence that we can provide effective COVID-19 prophylaxis using fusion inhibitors. We will also assess the potential of our antivirals to block host- to-host transmission.

PI_NAMEs: DE SWART, RIK L;POROTTO, MATTEO  (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Abbreviations;Address;Affinity;Animals;Anti-viral Agents;betacoronavirus;Binding;Biodistribution;Biological Assay;Cell Culture Techniques;Cell fusion;Cell membrane;Cell surface;cell type;Cells;Chiroptera;Common Cold;community transmission;Coronavirus;Coronavirus Infections;Couples;COVID-19;COVID-19 outbreak;COVID-19 pandemic;COVID-19 treatment;cytotoxicity;Data;design;Development;dimer;Disease;Disease Outbreaks;Distal;Dominant-Negative Mutation;Dose;endosome membrane;Endosomes;experimental study;Ferrets;fundamental research;genetic information;Glycoproteins;Homes for the Aged;Hospitals;Human;Immunologics;improved;In Vitro;in vivo;Infection;Infection prevention;inhibitor;Integration Host Factors;Life;Lipids;Mediating;Membrane;Membrane Fusion;Middle East Respiratory Syndrome Coronavirus;Modeling;Molecular;Molecular Conformation;monomer;Names;Nose;novel;novel coronavirus;pandemic disease;pandemic response;Peptide Hydrolases;Peptides;Population;pre-clinical;preclinical study;Predisposition;pressure;prevent;Process;Prophylactic treatment;Proteins;receptor;receptor binding;research clinical testing;SARS coronavirus;SARS-CoV-2 entry inhibitor;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 transmission;Severe Acute Respiratory Syndrome;Severity of illness;Surface;Testing;Therapeutic Intervention;Toxic effect;transmission process;uptake;Vaccinee;Vaccines;Viral;Viral Physiology;viral transmission;Virus;Virus Diseases;virus genetics;World Health Organization;Zoonoses

PROJECT_TITLE: Fusion inhibitors that block host-to-host transmission of SARS-CoV-2


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative We propose to structurally and functionally characterize the transcription and replication processes in SARS- CoV-2, the causative agent of the devastating disease COVID-19. The viral RNA-dependent RNA polymerase, which collaborates with a host of viral-encoded nucleic acid processing enzymes to establish infection and replication, is the central enzyme of transcription and replication and a proven target for antivirals such as remdesivir. Understanding how these enzymes function together and providing high-resolution structures provides insight that can lead to new therapeutics against this deadly pathogen.

PI_NAMEs: CAMPBELL, ELIZABETH A;DARST, SETH A. (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Active Sites;Anti-viral Agents;antimicrobial;antiviral drug development;Architecture;Binding;Biochemical;Biological Assay;Catalysis;Cells;Cessation of life;Classification;cofactor;Collaborations;Color;Complex;COVID-19;COVID-19 pandemic;Cryoelectron Microscopy;Data;Data Set;Development;Diphosphates;Disease;Drug Design;drug discovery;Drug Targeting;Effectiveness;Electrophoretic Mobility Shift Assay;endonuclease;Enzymes;Exonuclease;experimental study;Fluorescence;Fluorescence Microscopy;Foundations;Gel;Gene Expression;Genetic Transcription;Genome;Goals;Hand;helicase;Higher Order Chromatin Structure;Holoenzymes;Human Microbiome;illness length;improved;In Vitro;in vivo;Infection;inhibitor;insight;Investigation;large datasets;Manuscripts;Maps;Mass Spectrum Analysis;Methyltransferase;Modeling;Molecular;Molecular Conformation;Molecular Structure;N-terminal;new therapeutic target;novel;novel therapeutics;Nucleic Acids;nucleotide analog;Nucleotide Mapping;pathogen;Polymerase;protein protein interaction;Reaction;remdesivir;Replication-Associated Process;Reporting;Resolution;Rice;RNA Polymerase Inhibitor;RNA-Directed RNA Polymerase;Role;SARS coronavirus;SARS-CoV-2 genome;SARS-CoV-2 inhibitor;Scientist;Severities;single molecule;single-molecule FRET;Site;stoichiometry;Structure;Testing;Time;Transcription Process;Viral;Viral Genome;Viral Physiology;Virus;Virus Inhibitors;Virus Replication;Water

PROJECT_TITLE: Structure, function, and inhibition of the SARS-CoV-2 replication-transcription complex


PHR: The outbreak of SARS-CoV-2 highlights the need for an approach to developing effective antivirals; there are no vaccines or antivirals for SARS-CoV-2. We propose to apply our novel protein engineering strategies in a straightforward approach to developing SARS-CoV-2 peptide antivirals that inhibit entry of the virus into the host cell and are resistant to degradation, and based on our previous findings we have high confidence that we can provide effective prophylaxis using fusion inhibitors in vivo delivered via the airway. We will also assess the therapeutic potential of our antivirals for use in established disease.

PI_NAMEs: MOSCONA, ANNE  (contact)

PROJECT_TERMS: 2019-nCoV;airway epithelium;Amino Acids;Animals;Anti-viral Agents;anti-viral efficacy;Anti-viral resistance;betacoronavirus;Binding;Biodistribution;Biological Availability;Biophysics;C-terminal;Cell Culture Techniques;Cell fusion;Cell membrane;Cell surface;Cells;Cholesterol;Clinical;clinical efficacy;comparative efficacy;Coronavirus;Coronavirus Infections;Couples;COVID-19;COVID-19 outbreak;COVID-19 pandemic;COVID-19 treatment;Data;design;Disease;Dose;Engineering;Evolution;experimental study;Ferrets;Foundations;Future;Generations;Glycoproteins;Goals;Half-Life;Hamsters;HIV;Human;Immune response;improved;In Vitro;in vitro Assay;in vivo;in vivo evaluation;Individual;Infection;Infection prevention;Influenza;inhibitor;Integration Host Factors;Lipids;Measles;Measures;Mediating;Membrane;Membrane Fusion;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Modeling;Modification;Molecular;Molecular Conformation;monolayer;Nipah;novel;Parainfluenza;Paramyxovirus;pathogenic virus;peptide analog;peptide drug;Peptide Hydrolases;Peptides;Performance;Periodicals;Play;Predisposition;prevent;Prevention;Process;prophylactic;Prophylactic treatment;protein aminoacid sequence;Protein Engineering;Proteins;Proteolysis;prototype;receptor;receptor binding;Regimen;Resistance;resistance mechanism;Role;SARS coronavirus;SARS-CoV-2 antiviral;SARS-CoV-2 B.1.1.7;SARS-CoV-2 entry inhibitor;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 spike protein;SARS-CoV-2 transmission;Severe Acute Respiratory Syndrome;Site;Structure;Therapeutic;Tissues;Toxic effect;Translating;uptake;Vaccines;Vertebral column;Viral;viral entry inhibitor;Viral Physiology;viral transmission;Virus;Virus Diseases;Virus-Cell Membrane Interaction;Work

PROJECT_TITLE: Engineering protease-resistant antiviral peptide inhibitors for SARS-CoV-2


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The coronavirus pandemic impacts everyone's lives, cripples health care systems and causes a threat to the U.S. and the global economy. Other than remdesivir and dexamethasone, which display limited efficacy, there is no approved drug for the treatment of COVID-19, especially for prophylaxis and early treatment, and the discovery of an effective vaccine remains uncertain. This project aims to design and develop a safe and effective orally bioavailable antiviral agent targeting the SARS-CoV- 2 3CL protease (3CLpro), a critical viral protein required for virus replication, for the treatment of coronavirus disease 2019 (COVID-19).

PI_NAMEs: FITZPATRICK, ELIZABETH ANN;KOVARI, LADISLAU CHRISTOPHER;SCHINAZI, RAYMOND FELIX (contact)

PROJECT_TERMS: 2019-nCoV;absorption;Acids;Acute Respiratory Distress Syndrome;Affinity;analog;Animal Model;Animals;Anosmia;Anti-Inflammatory Agents;Anti-viral Agents;Anti-viral Therapy;antiviral drug development;aqueous;Binding;Biological Assay;Biological Availability;Caco-2 Cells;Cell Culture Techniques;Cells;Characteristics;China;clinical development;common symptom;Coronavirus;Coronavirus Infections;coronavirus pandemic;Coughing;COVID-19;COVID-19 prevention;COVID-19 therapeutics;COVID-19 treatment;Cytochrome P450;cytotoxicity;Data;design;Dexamethasone;Diarrhea;Disease;Docking;drug candidate;Drug Design;drug discovery;Drug Kinetics;Drug resistance;Dryness;Early treatment;efficacy evaluation;efficacy testing;Enterovirus;Enzyme Inhibition;Enzymes;Excretory function;Exhibits;Fever;Glycoproteins;Goals;Healthcare Systems;human coronavirus;Hybrids;In Vitro;inhibitor;Investigational New Drug Application;Lead;lead optimization;Libraries;Ligands;Liver Microsomes;Lung;Mesocricetus auratus;Metabolism;meter;Modeling;Molecular;molecular modeling;nanomolar;nonhuman primate;Norovirus;nucleoside analog;Oral;Outcome;pandemic disease;pandemic impact;Pathogenicity;Peptide Hydrolases;peptidomimetics;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;pharmacophore;Pharmacotherapy;Pneumonia;Polyproteins;preclinical study;Prevention;Preventive;programs;prophylactic;Prophylactic treatment;Protease Inhibitor;Province;Recombinant Proteins;remdesivir;Resistance;Ritonavir;SARS-CoV-2 antiviral;SARS-CoV-2 inhibitor;screening;Serum;Shortness of Breath;small molecule;small molecule inhibitor;Speed;Structure;Structure-Activity Relationship;System;targeted agent;Testing;Therapeutic;Therapeutic Index;Toxic effect;Treatment Efficacy;Vaccines;Viral;Viral Physiology;Viral Proteins;Viremia;virtual;virtual screening;Virus;Virus Inhibitors;Virus Replication;Work;X-Ray Crystallography

PROJECT_TITLE: Broad-spectrum therapeutics against SARS-CoV-2 3CL protease


ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Modified Public Health Relevance Section The Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2) can hijack the normal operations of human cells, which makes it especially dangerous. It encodes a set of nonstructural proteins (nsp) to protect its RNA genome from host degradation and immune restriction. Our studies will combine biochemical, structural, cellular, and genomic approaches to address fundamental questions related to RNA modification, host immune restriction, viral growth and pathogenesis, and develop new molecular tools to collectively inform new treatment for COVID-19 and other emerging viruses and protect ourselves against future viral infections.

PI_NAMEs: GUPTA, YOGESH K (contact)

PROJECT_TERMS: 2019-nCoV;Ablation;ACE2;Active Sites;Address;Amino Acids;analog;Anti-viral Agents;Architecture;Artificial Intelligence;Bacterial Artificial Chromosomes;betacoronavirus;Binding;Biochemical;Biological Assay;Biology;biophysical analysis;Biophysics;Cells;Chiroptera;combinatorial;Communication;Complex;convolutional neural network;Coronavirus;COVID-19;COVID-19 therapeutics;COVID-19 treatment;Crystallization;Cultured Cells;Dangerousness;Data;Disease;Distant;drug candidate;drug repurposing;Ebola;Economics;effective therapy;emerging virus;Enzymes;epidemiologic data;Future;genetic approach;Genetic Transcription;Genome;Genomic approach;Growth;Health;Human;Immune;Immune Evasion;Immune response;Immune system;improved;in vitro testing;in vivo;Individual;Infection;Innate Immune Response;innovation;Invaded;Investigation;K-18 conjugate;Lassa;Length;Libraries;Life Cycle Stages;Maintenance;Maps;Messenger RNA;Methods;methyl group;Methylation;Modeling;Modification;Molecular;Molecular Conformation;Monkeypox;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;Nature;Nonstructural Protein;novel;novel therapeutic intervention;Nucleoproteins;Nucleotides;operation;Organism;pandemic disease;Paper;Pathogenesis;programs;Property;protein complex;Proteins;public health relevance;Publishing;Recombinants;Recording of previous events;Reporting;Research;reverse genetics;RNA;RNA Binding;RNA Caps;RNA chemical synthesis;RNA Degradation;RNA Folding;RNA methylation;RNA Processing;RNA Viruses;S-Adenosylhomocysteine;S-Adenosylmethionine;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;screening;Series;small molecule;small molecule libraries;Solid;Specificity;stem;structural determinants;Structure;Structure-Activity Relationship;Surface;Technology;Testing;therapeutic target;Time;tool;transcriptomics;Translations;Untranslated Regions;vaccine development;Viral;Viral Genome;Viral Pathogenesis;Viral Proteins;viral RNA;Virion;Virus;Virus Assembly;Virus Diseases;Virus Replication;X-Ray Crystallography

PROJECT_TITLE: Mechanism-based Targeting of the RNA Processing Machinery of SARS-CoV-2


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE FOR ADMINISTRATIVE AND COORDINATING CORE The Administrative and Coordinating Core (ACC) will bring together investigators, institutions, community  liaisons, and resources in an inclusive environment to ensure the success of the CAMPO Consortium. The  ACC will oversee Consortium activities, monitor progress, and ensure that all components of the Consortium  are working together effectively. The ACC will provide guidance to the Executive Committee, which is  comprised of the three Principal Investigators and will serve as the decision-making body for the Consortium.

PI_NAMEs: PALEFSKY, JOEL MICHAEL (contact)

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Adenoviruses;Algorithms;Anus;California;career;career development;Cervical;cervical cancer prevention;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community advisory board;data management;Decision Making;Development;DNA;Ensure;Environment;Goals;HIV;HIV Seropositivity;HPV-High Risk;Human Papilloma Virus-Related Malignant Neoplasm;Immune response;Infrastructure;Institution;interest;international partnership;Laboratories;Latin America;Lesion;member;men;Mexico;microbiota profiles;Monitor;Policy Maker;Population;Prevention;Principal Investigator;Probiotics;programs;Puerto Rico;Research;Research Infrastructure;Research Personnel;research study;Resources;Safety;screening;Specific qualifier value;Squamous intraepithelial lesion;statistics;success;therapeutic HPV vaccine;United States National Institutes of Health;Woman

PROJECT_TITLE: CAMPO Administrative and Coordinating Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Immunotherapy;Infectious Diseases;Microbiome;Orphan Drug;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

PHR: NARRATIVE OF THE CLINICAL TRIALS PROGRAM The CAMPO Consortium Clinical Trials Program consists of three clinical research studies. The  Clinical Trials Program interacts with the CAMPO Cores to execute a research agenda designed to  reduce the burden of cervical and anal cancer in Latin America by improving screening and treatment  of cancer precursors in HIV-positive individuals.

PROJECT_TERMS: Adenoviruses;age related;Algorithms;Anus;California;cancer therapy;Caribbean region;CD8B1 gene;Cervical;cervical cancer prevention;Cervical Cancer Screening;Clinical Research;Clinical Trials;cost effective;cost effectiveness;Cytology;design;Detection;Disease;DNA;Genotype;Health Benefit;Healthcare;Hispanic;HIV;HIV Seropositivity;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune;Immune response;improved;Incidence;Individual;Infection;innovation;interest;Latin America;Lesion;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Mediating;men;Methylation;methylation biomarker;Mexican;Mexico;microbiome;microbiome alteration;microbiota;microbiota profiles;mortality;novel;novel strategies;novel therapeutics;Oncoproteins;Outcome;Performance;Placebos;Population;Predictive Value;Prevention;probiotic therapy;Probiotics;programs;protein expression;Proteins;Protocols documentation;Puerto Rican;Puerto Rico;Quality of life;Recommendation;recruit;Research;Research Personnel;research study;Resources;Risk Reduction;Safety;safety testing;screening;secondary endpoint;Site;Specificity;Squamous intraepithelial lesion;T-Lymphocyte;Testing;therapeutic HPV vaccine;therapeutic vaccine;Viral;Viral Markers;Viral Physiology;Woman

PROJECT_TITLE: CAMPO Clinical Trials Program


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

PHR: NARRATIVE FOR THE DATA MANAGEMENT AND STATISTICAL CORE The CAMPO Consortium’s Data Management and Statistics Core (DMSC) will support the three studies of the  Clinical Trials Program. The DMSC will work with the other Cores to provide input to study design, analysis of  collected data, and dissemination of results. In collaboration with The Emmes Corporation, the DMSC will  utilize a secure, scalable, and user-friendly platform for the capture of clinical research and biospecimen data.

PI_NAMEs: ZHANG, LI  (contact)

PROJECT_TERMS: Adenoviruses;Adherence;Algorithms;Anus;Area;Basic Science;Bioinformatics;Biometry;California;career;career development;Cervical;cervical cancer prevention;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Design;Collaborations;Collection;Complex Analysis;Consultations;cost;Data;Data Analyses;Data Collection;data management;data quality;Dedications;design;Discipline;DNA;Early identification;Ensure;Faculty;Fostering;Funding;Goals;HIV;HIV Seropositivity;HPV-High Risk;Human Papilloma Virus-Related Malignant Neoplasm;Immune response;Information Dissemination;Infrastructure;Laboratories;Latin America;Leadership;Lesion;men;Mentorship;Methodology;Mexico;microbiota profiles;Population;Prevention;Probiotics;programs;Protocols documentation;Publications;Puerto Rico;quality assurance;Reporting;Research;research data dissemination;Research Design;Research Personnel;research study;Research Training;Resource Sharing;Resources;Safety;sample collection;screening;Secure;Site;skills;Squamous intraepithelial lesion;Statistical Data Interpretation;statistics;success;Supervision;System;therapeutic HPV vaccine;Time;Training;Training Support;Translational Research;user-friendly;virtual;Woman;Work

PROJECT_TITLE: CAMPO Data Management and Statistical Core


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Immunization;Immunotherapy;Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

PHR: NARRATIVE FOR THE CENTRAL LABORATORY CORE The CAMPO Central Laboratory Core will perform laboratory assays in support of the three clinical research  studies to be performed as part of the CAMPO Clinical Trials Program. It will also perform correlative science  studies using clinical samples obtained from research participants in order to answer important questions  about how different treatment approaches may work to treat cancer precursors or reduce the risk of persistent  HPV infection.

PI_NAMEs: DARRAGH, TERESA MARIE (contact)

PROJECT_TERMS: Adenoviruses;Algorithms;Anus;Biological Assay;Biopsy;California;career;career development;cell mediated immune response;Cellular Immunology;Cervical;cervical cancer prevention;Clinic;Clinical;Clinical Research;Clinical Trials;Comprehensive Cancer Center;Data;data management;Diagnostic;Disease;Disease regression;disorder prevention;DNA;Ensure;Equipment;Grant;high risk;HIV;HIV Seropositivity;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune response;Laboratories;laboratory facility;Leadership;Lesion;Malignant Neoplasms;Measures;men;Mentorship;Mexico;microbiome analysis;microbiome research;microbiota profiles;Participant;Pathology;Population;Prevention;primary outcome;Probiotics;Procedures;programs;Protocols documentation;Puerto Rico;quality assurance;Quality Control;Reporting;Research;Research Personnel;research study;Risk Reduction;Role;Safety;Sampling;Science;Scientist;screening;Site;Specimen;Squamous intraepithelial lesion;statistics;Techniques;Technology Transfer;Testing;therapeutic HPV vaccinations;therapeutic HPV vaccine;therapeutic vaccine;Training;Training Programs;Training Support;Universities;vaccine trial;virtual;Woman;Work;working group

PROJECT_TITLE: CAMPO Central Laboratory Core


ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: Project narrative Off label use of existing drugs may offer protection, yet to date, the repurposed approaches studied for COVID- 19 treatment have demonstrated only modest utility and some have increased morbidity and mortality due to serious side effects. We have discovered a novel class of compounds that targets a host function and effectively suppresses replication of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) and other emerging viruses. We will optimize these compounds, determine their therapeutic potential and decipher their mechanism of antiviral action, thereby advancing the development of a class of antivirals that can provide readiness for resurge of COVID-19 and future outbreaks with coronaviruses and other newly emerging viruses.

PI_NAMEs: EINAV, SHIRIT  (contact)

PROJECT_TERMS: 2019-nCoV;absorption;activity-based protein profiling;Advanced Development;Alpha Virus;analog;Animal Model;Anti-viral Agents;Antineoplastic Agents;Binding;Biochemistry;Biological Assay;Biological Markers;Cells;chemical genetics;Chemicals;Clinical Research;Clinical Trials;combat;Coronavirus;Coronavirus Infections;COVID-19;COVID-19 outbreak;COVID-19 treatment;CRISPR interference;Cultured Cells;cytokine;Data Set;Dengue;Dengue Virus;design;Development;Dimensions;drug candidate;Drug Combinations;drug development;Drug Kinetics;drug repurposing;Ebola;Ebola virus;emerging virus;Endosomes;Erlotinib;Excretory function;future outbreak;future pandemic;GAK gene;Genetic;genome-wide;Genomics;Growth;Guide RNA;Hamsters;Human;In Vitro;in vivo;Individual;Industry;Inflammation;Inflammatory;Inflammatory Response;inhibitor;insight;Integration Host Factors;Investigational Drugs;Laboratories;Lead;Life Cycle Stages;Lung;Measures;Mediating;Membrane;Metabolism;Modeling;Molecular;Molecular Target;Molecular Virology;Monitor;Morbidity - disease rate;mortality;Mus;novel;off-label use;Organoids;pandemic coronavirus;Pathway interactions;Peripheral Blood Mononuclear Cell;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacology Study;Phosphotransferases;preclinical safety;Production;programs;Property;Proteomics;pyridine;Readiness;Regimen;Reporting;Research;Resistance;Resources;response;Risk;RNA Viruses;Rodent Model;Role;Safety;SARS-CoV-2 entry inhibitor;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 pathogenesis;Series;Severe Acute Respiratory Syndrome;side effect;small molecule;Structure of parenchyma of lung;Structure-Activity Relationship;Study models;Therapeutic;Therapeutic Index;tissue injury;tool;Toxic effect;Toxicology;trafficking;Translating;treatment response;Viral;Viral Load result;Viral Physiology;virology;Virus;Virus Diseases;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Advancing the development of a novel class of small molecules for treating pan-coronavirus infections


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Rural Health;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: EUGENE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE Rigorous research is needed to identify mechanisms contributing to sexual minority health disparities, particularly from an intersectionality perspective. The intersectionality of geographic location and sexual orientation can profoundly impact prevalence of suicidal thoughts and behaviors, as rural sexual minorities experience disproportionate burden of suicidal thoughts and behaviors, often reside in high-stigma environments, and have limited access to healthcare resources. This project uses an innovative mixed methods approach to clarify acute and dynamic mechanisms underlying suicidal thoughts and behavior disparities among rural sexual minority adults and will inform therapeutic targets for suicide prevention in this uniquely high-risk population.

PI_NAMEs: FORREST, LAUREN NICOLE (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Adult;Age;aged;Award;barrier to care;behavior prediction;Birth;Bisexual;career;Cause of Death;Cellular Phone;Clinical;college;Communities;Data;Data Analyses;Dedications;Disparity;Ecological momentary assessment;Enrollment;Environment;Ethnic Origin;Exclusion;experience;Feeling suicidal;Fibrinogen;follow-up;Future;Gays;Gender;gender minority group;Geographic Locations;Goals;health care availability;Health Services Accessibility;Heterosexuals;high risk population;HIV/AIDS;Hour;Individual;innovation;Institution;Internet;intersectionality;Interview;Learning;Lesbian;Medicine;Mental Health;Mentors;Methods;minority stress;Modeling;Participant;Pattern;Pennsylvania;Persons;Prevalence;prevent;Prevention;Procedures;Process;Protocols documentation;Qualitative Methods;Race;Reporting;Research;Resources;response;Risk;Risk Behaviors;Risk Factors;Rural;Rural Community;rurality;Sampling;Scientist;Severities;sex assigned;Sex Orientation;sexual minority;sexual minority group;sexual minority health;sexual minority health disparity;skills;social stigma;Structure;Subgroup;suicidal behavior;suicidal risk;Suicide;Suicide prevention;Surveys;systematic review;Testing;therapeutic target;Training;Training Activity;Universities;urban area;Work

PROJECT_TITLE: Predicting acute and dynamic suicide risk in rural sexual minorities


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Hematology;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: Project Narrative: The mortality and morbidity due Sickle Cell Disease, a genetic blood disorder predominantly found in sub- Saharan Africa, has been reduced in high income countries using evidence-based interventions. This project aims to implement innovations including electronic registry, standards of care, as well as cohort and implementation science research to transform SCD outcomes in this setting. The anticipated findings of the project will inform policy formulation and sustainable roll out of evidence-based interventions in Uganda and the rest of sub-Saharan Africa.

PI_NAMEs: KIGULI, SARAH  (contact)

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: Acute;acute chest syndrome;Address;Adolescent;Adopted;Adoption;Adult;Affect;Africa South of the Sahara;African;Age;Anemia;Area;biobank;burden of illness;Caring;Cessation of life;Characteristics;chemotherapy;Child;Child Health;Child Mortality;Childhood;Clinic;clinical care;clinical phenotype;cohort;Cohort Studies;college;Comprehensive Health Care;Consent;Country;Data;data management;Databases;Detection;Diagnosis;Disease;Disease Management;Disease Outcome;disease registry;electronic registry;Electronics;Erythrocytes;Ethical Issues;Ethics;evidence base;Evidence based intervention;fighting;Formulation;Funding;Genes;Genetic;Genetic Counseling;Goals;graduate student;Grant;Guidelines;Health;Health Sciences;Hematological Disease;Hematology;Hemoglobin;Hereditary Disease;High Prevalence;hydroxyurea;implementation research;implementation science;improved;Income;Individual;Infection;innovation;Intervention;Investments;Legal;Life;Maintenance;Medical;Microalbuminuria;Morbidity - disease rate;mortality;Natural History;Neonatal Screening;Neurocognitive Deficit;Oncology;Outcome;Pain;Participant;participant enrollment;Patient-Focused Outcomes;Patients;pediatric department;Penicillins;Phenotype;Policies;Prevalence;Prevention;Preventive;programs;Prophylactic treatment;Recording of previous events;Records;recruit;Recurrence;Registries;Research;Research Project Grants;research study;Resources;Rest;screening;screening program;SERPINI2 gene;Sickle Cell;Sickle Cell Anemia;sickling;Site;Stroke;student training;success;System;Time;Training;trait;Uganda;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Sickle Pan-African Research Consortium (SPARCO) Uganda: Strengthening Capacity for Clinical Care, Research and Training in Sickle Cell Disease - SCRT Project.


PHR: Our goal is to develop towards an IND a novel class of small molecule inhibitors of phosphoinositide (PI) 4 kinase IIIb (PI4KIIIb) with potent dual activity against both SARS-CoV-2 and the excess cytokine release associated with COVID-19 disease. Our lead inhibitor, STF-1019 has nanomolar antiviral activity, potently inhibits the LPS-induced secretion of IL-6 from human PBMC, is orally bioavailable and well tolerated in mice, although its metabolic stability is suboptimal, requiring co-administration with an inhibitor (i.e. ritonavir) of its metabolism by CYP3A4 for optimal sustained tissue exposure. We now seek to identify an analog of STF-1019 with improved metabolic stability to enable convenient once-a-day dosing so that we can begin to assemble the future IND package.

PI_NAMEs: GLENN, JEFFREY S (contact)

PROJECT_TERMS: 2019-nCoV;Address;analog;Animal Model;animal safety;Anti-viral Agents;Anti-viral resistance;Biological Availability;Buffers;Caco-2 Cells;Cells;COVID-19;CYP3A4 gene;cytokine;cytokine release syndrome;Development;Disease;Dose;drug development;Drug Kinetics;Enterovirus;Enterovirus 71;experimental study;Future;Goals;Golgi Apparatus;Hour;Human;IL-6 inhibitor;IL8 gene;improved;In Vitro;in vivo;inhibitor;Interferons;Interleukin-6;knock-down;Lead;lead optimization;Lipids;Maximum Tolerated Dose;Mediating;Metabolic;Metabolism;Modeling;Modification;mouse model;multidisciplinary;Mus;nanomolar;novel;Oral;Organelles;Peripheral Blood Mononuclear Cell;Permeability;Pharmaceutical Chemistry;Phosphatidylinositols;Phosphorylation;Phosphotransferases;pre-clinical;Production;Protein Isoforms;remdesivir;Resistance;Resistance development;Ritonavir;Role;safety study;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;Serum;Severe Acute Respiratory Syndrome;severe COVID-19;Site;Small Interfering RNA;small molecule inhibitor;standard of care;Structure-Activity Relationship;synergism;Testing;Therapeutic Index;Tissues;Toxic effect;Viral;Viral Physiology;virology;Virulent

PROJECT_TITLE: Optimizing a small molecule inhibitor of SARS-CoV-2 replication and associated cytokine storm


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dental, Oral, and Craniofacial Disease;Depression;Infectious Diseases;Mental Health;Mental Illness;Microbiome;Pediatric;Sleep Research

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

ORG_STATE: RI

PI_NAMEs: NARCISSE, MARIE-RACHELLE  (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;adolescent mental health;Adult;Affect;Age;Centers of Research Excellence;Child;child depression;Chronic;Circadian desynchrony;Circadian Rhythms;Clinical Research;Data;Dental caries;depressive symptoms;Development;experience;Foundations;Goals;Habitats;Human;Inflammation;Mental Depression;Microbe;microbial;microbial community;microbial composition;microbiome composition;microbiome research;Modeling;National Health and Nutrition Examination Survey;Observational Study;Oral cavity;oral microbiome;pathogen;Pattern;Phenotype;Population;Public Health;Research;Rest;Role;Sampling;Sleep;Sleep Deprivation;Taxonomy;United States;Work;young adult

PROJECT_TITLE: Sleep and Circadian Rhythm Phenotypes in Adolescent Depression: Exploring the Role of the Oral Microbiome


PI_NAMEs: COHN, ELIZABETH GROSS;HERSHMAN, DAWN ;PHILLIPS, ERICA ;SHIMBO, DAICHI ;TERRY, MARY BETH  (contact);WILLIAMS, OLAJIDE

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: COLLEGE STATION

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Project Narrative Heterotopic ossification (HO), characterized by formation of extra-skeletal bone as a consequence to traumatic injury or genetic disorders, is a medical condition that results in significant cost and patient suffering. In this proposal, we aim to clarify the cellular and molecular mechanisms underlying this condition and identify potential treatment targets. Results from the proposed studies will not only yield novel insights into the pathogenesis and treatment of HO but may also be applicable to studying a class of diseases that may share similar core mechanisms.

PI_NAMEs: CONG, QIAN  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: achilles tendon;acquired heterotopic ossification;Affect;Automobile Driving;Binding;bone;Bone Development;Bone Diseases;cartilage development;Cell Differentiation process;cell motility;cell type;chronic pain;Clinical;Complication;cost;Data;Defect;Development;Disabling;Disease;Ectopic Expression;effective therapy;Embryonic Development;Erinaceidae;Event;Family;Feedback;Genetic;Genetic Diseases;Genetic Transcription;Goals;GTP-Binding Protein alpha Subunits, Gs;Heterotopic Ossification;Human;human disease;In Vitro;in vivo Model;Injury;insight;Joints;Knowledge;Lead;Lesion;Ligands;long bone;Medical;Mesenchymal;migration;Modeling;Molecular;Motion;mouse model;Mus;new therapeutic target;novel;null mutation;Online Mendelian Inheritance In Man;Operative Surgical Procedures;osteoblast differentiation;Osteoblasts;Osteogenesis;Outcome;Pathogenesis;Pathologic;Patients;Play;Population;Probability;progressive myositis ossificans;Progressive osseous heteroplasia;Promoter Regions;Puncture procedure;rare genetic disorder;receptor;recruit;Recurrence;Regulation;response;Role;ROR1 gene;Sampling;SHH gene;Signal Transduction;soft tissue;stem cell proliferation;stem cells;Surgical complication;Tendon structure;Testing;Therapeutic Studies;therapeutic target;therapeutically effective;transcription factor;Trauma;Traumatic injury;Up-Regulation

PROJECT_TITLE: Mechanistic and Therapeutic Studies of Initiation and Expansion for Genetic and Acquired Heterotopic Ossification

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Colorectal Cancer;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PI_NAMEs: HELMY, YOSRA A. (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: 3-Dimensional;Affect;American Cancer Society;Animals;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Bacteria;Benchmarking;Binding;Birds;Cell Wall;Cells;Centers of Research Excellence;Chickens;Chronic;Colon Carcinoma;comparative efficacy;Competence;Development;Disease;DNA metabolism;Domestic Fowls;drug resistance development;Drug Targeting;Drug usage;efficacy evaluation;egg;Exposure to;Food Chain;Food Poisoning;foodborne;Genetic;Growth;Health;Human;Immune response;In Vitro;Infection;inhibitor;innovation;Intestines;Lead;Link;Malignant neoplasm of gallbladder;Malignant Neoplasms;Meat;Metabolism;Microbial Biofilms;Motility;novel strategies;novel therapeutics;pathogen;Pathogenicity;Pharmacologic Substance;Play;Pluripotent Stem Cells;Poisoning;Poultry Products;Predisposition;pressure;Production;Protein Biosynthesis;Public Health;quorum sensing;Research;Resistance development;Risk;risk mitigation;Role;Salmonella;Salmonella food poisoning;Salmonella infections;Salmonella typhi;Salmonella typhimurium;Salmonella Vaccines;screening;Serotyping;Source;stem cell organoids;Therapeutic;Vaccination;VAI-2;Virulence;Virulent

PROJECT_TITLE: Novel therapeutics for controlling antibiotic-resistant Salmonella infections in humans


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Genetics;Health Services;Prevention;Women's Health Research

PHR: PROJECT 2: Narrative Risk-based screening is being studied as an improvement on current age-based approaches but relies on well- performing risk models to be effective. This project aims to advance the genetic models (polygenic risk scores) being used in the WISDOM Study of risk-based screening by: 1) optimizing their cross-ancestry performance; 2) adapting them to better predict fast-growing cancers; and 3) determining how they can be used to identify women who may benefit from shorter intervals of screening. We expect the knowledge generated in Project 2 to advance breast cancer risk prediction, improve the effectiveness of risk-based screening, and facilitate the translation of polygenic risk scores to the clinic.

PI_NAMEs: SHIEH, YIWEY  (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Acceleration;Address;advanced breast cancer;Advanced Malignant Neoplasm;African;Age;Aging;Algorithms;American Joint Committee on Cancer;Area;arm;Artificial Intelligence;Biometry;Breast Cancer Detection;Breast Cancer Genetics;Breast Cancer Risk Factor;case control;Clinic;Clinical;clinical risk;cohort;Data;Data Set;Databases;Decision Making;Disease;Disparity;diverse data;Early Diagnosis;East Asian;Effectiveness;Epidemiology;epidemiology study;Evolution;experience;Genetic;genetic epidemiology;Genetic Models;genetic risk factor;genetic testing;genome wide association study;Germ Lines;Goals;High Risk Woman;improved;improved outcome;Incidence;Indigenous American;Individual;Industry;Institution;Joints;Knowledge;Latina Population;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Modality;Modeling;models and simulation;Molecular Profiling;mortality;multidisciplinary;multimodality;Mutation;Outcome;Participant;Pathogenicity;Pathologic;Pathway interactions;Performance;Phase;polygenic risk score;Population;population based;Population Heterogeneity;Prevention;prognostic;Proliferating;radiological imaging;radiomics;receptor;Recommendation;Research;Resources;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;risk stratification;routine screening;screening;Single Nucleotide Polymorphism;SNP genotyping;statistics;Testing;Translating;Translations;tumor;Validation;Variant;Woman;Work

PROJECT_TITLE: Project 2: Optimizing polygenic risk scores to inform breast cancer screening and prevention

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-T (M1)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Women's Health Research

PHR: PROJECT 3: Narrative Our ongoing WISDOM trial of risk-based breast cancer screening and prevention is predicted to reduce harms from screening by 50% while continuing to reduce advanced breast cancers as much as annual screening; however, the underlying risk model has high potential for improvement. The overall goal of Project 3 is to continuously develop and improve models for predicting the risk of breast cancer by combining emerging advances in artificial intelligence, inherited genetics, and tumor molecular assays. We will use these advanced models to predict risk of fast- vs. slow-growing breast cancer subtypes and to create a next-generation WISDOM risk-based screening and prevention platform, which, based on our preliminary data, we expect will be substantially more useful than the current WISDOM risk model and enable further reduction in harms from both lethal breast cancers and abundant false positives.

PI_NAMEs: ARASU, VIGNESH A (contact)

PROJECT_TERMS: 3-Dimensional;advanced breast cancer;Advanced Malignant Neoplasm;Age;Artificial Intelligence;artificial intelligence method;artificial intelligence model;Biological Assay;Breast Cancer Detection;Breast Cancer Risk Factor;breast density;Cancer Intervention and Surveillance Modeling Network;cancer subtypes;Classification;Clinical;clinical predictors;clinical risk;clinically relevant;cohort;Cohort Studies;comparative effectiveness study;Consensus;cost;Data;deep learning;Ethnic Origin;Genetic;Genetic Predisposition to Disease;genome wide association study;Genomics;Germ Lines;Goals;Growth;Harm Reduction;Health;high risk;High Risk Woman;Image;improved;Incidence;Individual;Inherited;innovation;Joints;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Modeling;models and simulation;Molecular;Molecular Profiling;molecular subtypes;Morbidity - disease rate;mortality;multidisciplinary;Mutation;next generation;novel;Outcome;Penetrance;Performance;personalized strategies;polygenic risk score;Population;Predictive Factor;predictive modeling;Prevention;Prevention trial;Preventive measure;Race;radiomics;Recommendation;Recurrence;Research;Risk;Risk Factors;risk prediction;risk prediction model;routine screening;screening;screening guidelines;simulation;Single Nucleotide Polymorphism;tomosynthesis;Training;tumor;Update;Woman

PROJECT_TITLE: Project 3: Integration of mammographic AI, clinical, and genomics information to improve breast cancer subtype-specific risk-based screening and prevention


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: TUCSON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Our proposal seeks to unravel the molecular mechanisms underlying severe non-syndromic cochleovestibular and cochleovestibular nerve malformations. We will employ a comprehensive genomic analysis to identify the key molecular events implicated in the development of these malformations. Our proposed research promises to yield novel insights into inner ear development and can pave the way for the development of better molecular diagnostic tools and future personalized treatment.

PI_NAMEs: SCHRAUWEN, ISABELLE VEERLE SUZANNE (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Affect;African;Anatomy;autosome;Belgium;Bilateral;bone imaging;Candidate Disease Gene;causal variant;Cells;Child;Child Development;Cities;Clinical;Cochlea;cohort;Collaborations;Collection;Complex;congenital hearing loss;cost effective;Counseling;Country;craniofacial;dark matter;Data;Data Set;Databases;de novo mutation;Defect;demographics;Developed Countries;Development;Diagnosis;Diagnostic;diagnostic screening;diagnostic tool;Disabling;Disease;DNA;Ear;ethnic diversity;ethnic health disparity;Ethnic Origin;Ethnic Population;Etiology;Event;exome;exome sequencing;experimental study;Family;Future;Gene Expression;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;genetic variant;genome sequencing;genomic data;genomic variation;Genomics;health disparity;hearing impairment;Height;Hispanic;Hispanic Populations;Hospitals;Human;Image;Imaging Techniques;improved;In Situ Hybridization;Individual;inner ear development;innovation;insight;Intervention;Knowledge;Labyrinth;Magnetic Resonance Imaging;malformation;Methods;Mexico;Modeling;Molecular;Molecular Diagnosis;Molecular Diagnostic Testing;molecular diagnostics;Nerve;Neural Crest;New York City;Newborn Infant;Not Hispanic or Latino;novel;novel therapeutic intervention;Otolaryngologist;outcome prediction;Parents;participant enrollment;Pathogenicity;Patients;personalized medicine;Phenotype;phenotypic data;Population;Population Heterogeneity;preference;proband;Productivity;Race;racial diversity;racial health disparity;racial population;recruit;Repetitive Sequence;repository;Research;Resolution;Resources;RNA analysis;screening;Sensorineural Hearing Loss;Sensory;Site;sound;South Asian;Temporal bone structure;Therapeutic;therapeutic development;Therapeutic Intervention;transcriptome sequencing;United States;Variant;Washington;Work;X-Ray Computed Tomography

PROJECT_TITLE: Unraveling the genetic architecture of cochleovestibular malformation

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE Ovarian cancer is a major public health issue and is often diagnosed in later stages, resulting in an increased risk of death. Extracellular vesicles are nanoscale particles that circulate throughout bodily fluids and are released by all cells, and their cargo may indicate early signs of ovarian cancer or inform better treatment strategies. The proposed training and research will create improved methods for characterizing and classifying extracellular vesicles to improve patient outcomes by developing ultrasensitive detection devices and machine learning analytical tools.

PI_NAMEs: HISEY, COLIN LEE (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: advanced disease;algorithm training;analytical tool;aptamer;Architecture;Bar Codes;Biochemical;Biological Assay;Biological Markers;Bioreactors;Body Fluids;Cancer Patient;cancer subtypes;Cell Culture Techniques;Cells;Cessation of life;Chemicals;Classification;classification algorithm;Clinical;clinical application;clinical translation;Column Chromatography;Communicable Diseases;Complementary Feeding;Data;data acquisition;Data Analytics;Data Set;Dependence;design;Detection;Development;Devices;Diagnosis;Diagnostic;Diagnostic Neoplasm Staging;Disease;disease classification;disease diagnosis;disease diagnostic;disorder subtype;electron beam lithography;Engineering;Etiology;experimental study;extracellular vesicles;Fatality rate;Fingerprint;generative adversarial network;Geometry;Goals;Gold;Health;Heterogeneity;Human;Image;improved;innovation;interest;Intervention;Label;Laboratories;Lateral;Lipids;Machine Learning;machine learning algorithm;machine learning classification;machine learning classifier;Malignant neoplasm of ovary;Malignant Neoplasms;Mentors;Methods;Microfluidic Microchips;Microfluidics;Molecular Biology;Molecular Sieve Chromatography;Monitor;mortality risk;multidisciplinary;nanofabrication;nanoparticle;nanoplasmonic;nanoscale;Nature;new technology;Optics;particle;Patient-Focused Outcomes;Patients;Pattern;Phase;Plasma;Population;Positioning Attribute;prevent;Process;Production;programs;Public Health;Raman Spectrum Analysis;rapid growth;Reproducibility;reproductive system disorder;Research;Resolution;Sampling;sensor;Serous;Signal Transduction;simulation;skills;Source;Spectrum Analysis;Staging;Sulfhydryl Compounds;Surface;Surface Antigens;Survival Rate;Symptoms;Techniques;Testing;tool;Training;Translating;Translations;treatment strategy;vesicular release;Woman

PROJECT_TITLE: Machine Learning-enabled Classification of Extracellular Vesicles Using Nanoplasmonic Microfluidics

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emergency Care;HIV/AIDS;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Women's Health Research

PI_NAMEs: KOSGEI, ROSE JEPCHUMBA (contact)

PROGRAM_OFFICER_NAME: SIVARAM, SUDHA

PROJECT_TERMS: Acceleration;Accident and Emergency department;Acetic Acids;Address;Adherence;Adopted;Adoption;Africa South of the Sahara;Age;Attitude;Awareness;base;behavior change wheel;Breast Cancer Detection;Breast Cancer Early Detection;Breast Cancer Treatment;Cancer Control;Cancer Etiology;care fragmentation;career;Caring;Cervical;Cervical Cancer Screening;Cessation of life;Clinic;Clinical;Clinical Trials;Collaborations;Communities;community engagement;Complex;cost;Data;design;Development;Diagnosis;Early Diagnosis;Early treatment;Effectiveness;effectiveness outcome;effectiveness/implementation study;Ensure;Equity;Faculty;feasibility testing;Female;follow-up;Government;Guidelines;Health;Health Services Accessibility;HIV Seropositivity;Hospitals;Human;Human Papillomavirus;Human Resources;Hybrids;implementation evaluation;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Incidence;Information Technology;Infrastructure;Institution;International;Intervention;intervention cost;Kenya;Knowledge;knowledge translation;Lesion;Letters;Link;low and middle-income countries;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Measures;Mentors;Meta-Analysis;Methods;mHealth;mobile application;Morbidity - disease rate;mortality;Motivation;Oncology;Outpatients;patient oriented;patient screening;Patients;Policies;Policy Making;premalignant;Preparation;Primary Care;primary care clinic;primary care setting;Procedures;programs;Provider;Readiness;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Research Technics;Resources;response;screening;Screening for cancer;screening guidelines;self testing;Site;Structure;Students;System;Technology;Telephone;Testing;Text;Time;Training;treatment services;Triage;Universities;uptake;user-friendly;Visual;Washington;Woman;Women's mortality

PROJECT_TITLE: Enhanced Cervical Cancer Screening Adoption and Treatment Linkage for HIV positive Women in Kenya (eCASCADE-Kenya)


NIH_SPENDING_CATS: Women's Health Research

PHR: Project Narrative The UCSF-KPNC Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) Program offers mentored training to scholars to advance women’s health and health equity in the U.S. through the study of sex and gender influences in health and disease. This proposal will directly support the career development of a scholar underrepresented in medicine and help to strengthen a diverse scientific workforce in women’s health research. It will also provide support for a postdoctoral scholar, increasing focus on significant public health issues in women’s health. The program strengthens interdisciplinary research skills and trains women’s health researchers for successful careers in team science focused on topics of public health importance, ultimately improving U.S. health outcomes and health equity.

PI_NAMEs: BRINDIS, CLAIRE D.;HARPER, CYNTHIA C (contact)

PROGRAM_OFFICER_NAME: TIGNO, XENIA

PROJECT_TERMS: addiction;Administrative Supplement;Advisory Committees;Biomedical Research;bone health;California;career;career development;Clinical Research;Clinical Sciences;Cognition;Communicable Diseases;Discipline;Disease;Environmental Health;Ethnic Origin;experience;Faculty;Fostering;Funding;Gender;Health;health equity;improved;Institution;interdisciplinary approach;Interdisciplinary Study;interest;Leadership;leadership development;life span;Malignant Neoplasms;Measures;Medicine;member;Mental Health;Mentored Clinical Scientist Development Program;Mentors;Metabolism;Modeling;Outcome;outreach;peer;Postdoctoral Fellow;Productivity;Program Effectiveness;Program Evaluation;programs;Public Health;Race;recruit;Reproductive Health;Research;Research Personnel;San Francisco;Science;sex;Surveys;Training;training opportunity;Translational Research;Universities;Woman;Women's Health

PROJECT_TITLE: UCSF-Kaiser Department of Research Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Program


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Niemann-Pick Type C (NPC) disease is a lysosomal storage disorder with no cure or approved treatment. This project will seek to establish a panel of biomarkers in NPC that can be used for future clinical trials.

PI_NAMEs: COLOGNA, STEPHANIE M (contact)

PROGRAM_OFFICER_NAME: MUELLER, CHRISTINE

PROJECT_TITLE: Clinically Relevant Biomarkers for Niemann-Pick Type C


ORG_CITY: SAINT LOUIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE The goal of this project is to establish infrastructure to perform surveillance for new emerging infectious diseases, identify novel viruses responsible for the disease and to develop essential reagents to define the epidemiology and pathogenesis of these viruses.

PI_NAMEs: WANG, DAVID  (contact)

PROGRAM_OFFICER_NAME: WOODSON, SARA ELAINE

PROJECT_TERMS: Africa;Animal Model;animal model development;Animals;antigen detection;assay development;Bioinformatics;Biological Assay;Camels;Case Fatality Rates;Cell Culture System;China;Clinical;Consensus;Consultations;Coronavirus;Dengue;Dengue Virus;Development;Diagnostic;diagnostic assay;diagnostic development;Disease;Disease Surveillance;Emerging Communicable Diseases;Emerging infection;emerging virus;Encephalitis;Epidemiology;Ethiopia;Event;Family;Ferrets;Fever;Fever of Unknown Origin;Genetic;Genome;Genomics;Goals;high risk;Hong Kong;Human;Immune;Immunology;Infection;Infectious Diseases Research;Influenza;Influenza A Virus, H5N1 Subtype;Infrastructure;Insect Vectors;International;Malaysia;Metadata;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Modeling;Molecular Biology;Monoclonal Antibodies;mouse model;National Institute of Allergy and Infectious Disease;Nepal;neutralizing antibody;new outbreak;next generation sequencing;novel;novel virus;Pathogenesis;Pathogenicity;Pattern;Prevalence;Public Health;Reagent;Recording of previous events;Reporting;Respiratory Disease;respiratory pathogen;respiratory virus;response;Reverse Transcriptase Polymerase Chain Reaction;SARS coronavirus;Serology;Serology test;Seroprevalences;Site;Southeastern Asia;Specimen;surveillance study;Syndrome;Therapeutic;therapeutic candidate;Thrombocytopenia;Time;transmission process;Variant;vector;Viral;Viral Pathogenesis;viral transmission;virology;Virus;Virus Receptors;Zoonoses

PROJECT_TITLE: Emerging infections: surveillance, epidemiology and pathogenesis


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Prevention;Pulmonary Hypertension;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative In this proposal, I aim to use a new method to define a human DNA mutation and a protein named FUBP1 that binds to this mutation as an explanation as to why some people are more likely to develop a deadly blood vessel disease in lungs called pulmonary hypertension. If successful, my work could change our understanding of pulmonary hypertension and drive development of new ways to detect and treat this deadly disease.

PI_NAMEs: SUN, WEI  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Affinity;Alleles;Allelic Imbalance;Animal Model;Architecture;Basic Science;Binding;Biology;Blood Vessels;career;career development;Cell Line;Clinical;Coupled;CRISPR/Cas technology;Data;Dependence;Dependovirus;Development;Diagnostic;Disease;Disease susceptibility;DNA Binding;DNA Sequence Alteration;Down-Regulation;endothelial dysfunction;Endothelium;Enterochromaffin Cells;Environment;Experimental Animal Model;familial hypertension;Functional disorder;functional genomics;Future;gene editing technology;Gene Expression;gene-editing approach;Genes;Genetic;genetic association;Genetic Predisposition to Disease;genome wide association study;Genomic approach;genomic locus;genomic platform;Genomics;Genotype;Goals;Haplotypes;Human;human DNA;Hypoxia;in vivo;induced pluripotent stem cell;insight;Intervention;knock-down;Knockout Mice;Knowledge;knowledge base;Link;Linkage Disequilibrium;Lung;Lung Diseases;lung hypoxia;Mediating;Mentors;Methods;Molecular;Molecular Target;mouse model;Mus;Mutation;Names;nanoparticle;nanopolymer;novel;overexpression;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Persons;Physicians;Predisposition;Proteins;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary Hypertension;Reporting;Research;Research Personnel;Research Project Grants;Research Technics;Resources;Risk;risk variant;Role;Sampling;Scientist;Severities;Single Nucleotide Polymorphism;siRNA delivery;skills;SOX17 gene;stem cell biology;Structure of parenchyma of lung;Testing;Training;transcription factor;Translational Research;Universities;Untranslated RNA;Validation;vector;virulence gene;Work

PROJECT_TITLE: Post-GWAS Functional Genomics Analysis to Define Pathogenic Mechanisms for Pulmonary ArterialHypertension

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: HIV/AIDS;Pediatric;Pediatric - AIDS

ORG_CITY: ROCKVILLE

ORG_NAME: FISHER BIOSERVICES, INC.

ORG_STATE: MD

PI_NAMEs: MARTIN, BRITTANY  (contact)

PROJECT_TERMS: Address;Annual Reports;base;Biological;Biological Specimen Banks;Cataloging;Child Health;Childhood;Collection;Communication;computerized;Contractor;Contracts;Coupled;Cryopreservation;data exchange;Database Management Systems;Ensure;Equipment;Equipment and supply inventories;Extramural Activities;Human;Human Development;Human Resources;Infrastructure;National Institute of Child Health and Human Development;Neonatal;Online Systems;operation;Pregnancy;quality assurance;Regulation;Reporting;repository;Research;Research Activity;Sampling;Secure;Services;Shipping;Specimen;Support System;System;Training

PROJECT_TITLE: NICHD HUMAN BIOSPECIMEN REPOSITORY


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Biomedical Imaging;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Infectious Diseases;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_NAME: NATIONAL INSTITUTE ON AGING

PI_NAMEs: KAPOGIANNIS, DIMITRIOS  (contact)

PROJECT_TERMS: Aging;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Amyloidosis;Animal Model;Anti-Inflammatory Agents;apolipoprotein E-4;Astrocytes;atherosclerosis risk;Atrophic;Baltimore;Biological Markers;Bipolar Disorder;Blood;brain cell;Brain Diseases;California;Case/Control Studies;Clinical;Clinical Trials;Cognition;Cognition Disorders;Cognitive;cognitive performance;cohort;Communities;Dementia;Deposition;Development;diabetes prevention program;Diagnosis;Diagnostic;Disease;Disease Progression;exenatide;extracellular vesicles;Fragile X Syndrome;Functional Magnetic Resonance Imaging;Future;General Population;Genotype;GLAST Protein;Goals;Human;Impaired cognition;Inflammatory;infliximab;Institution;Insulin;Insulin Resistance;insulin signaling;Intervention;Iron-Regulatory Proteins;Life;Long COVID;Longitudinal cohort;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediator;Memory;Mental disorders;Metabolic;Methodology;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Monitor;Multiple Sclerosis;mutation carrier;Nerve Degeneration;Nervous System Disorder;Neural Cell Adhesion Molecule L1;neuroinflammation;Neurologic;Neurons;neuropathology;Neurosciences;Outcome Study;Parkinson Disease;Participant;Persons;Phosphorylation;Plasma;Positron-Emission Tomography;pre-clinical;Prediction of Response to Therapy;predictive marker;Process;Proteins;Registries;Research Project Grants;resilience;Restless Legs Syndrome;Risk;Sampling;SARS-CoV-2 infection;Schizophrenia;Serum;Signal Transduction;Source;Surface;Synapses;tau mutation;tau Proteins;tau-1;Texas;Traumatic Brain Injury;Tremor/Ataxia Syndrome;Universities;Vesicle;Wisconsin;Women's Health

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Developing Extraceullar Vesicle biomarkers for clinical and preclinical AD/ADRD


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: RESNICK, SUSAN  (contact)

PROJECT_TERMS: Acceleration;Adult;Age;age related;Age Years;aged;Aging;aging biomarker;aging brain;aging related;Agreement;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Autopsy;Baltimore;Biological Assay;Biological Markers;biomarker performance;Brain;cerebral atrophy;Clinical;Cognitive;Cognitive aging;cognitive change;cognitive testing;Collaborations;Darkness;Data;Dementia;depressive symptoms;Diagnosis;Disease;Disease Marker;early detection biomarkers;Early identification;Enrollment;Extramural Activities;Family;Gait;Genetic;Goals;Health;hearing impairment;Home;Hormonal;Image;Impaired cognition;Individual;Infection;interest;Investigation;Learning;lipidomics;Longitudinal Studies;Measures;Memory;Metabolic;mild cognitive impairment;Mission;Mitochondria;Motor;multisensory;Muscle;National Institute on Aging;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;Neurologic;neuropathology;Neuropsychology;Participant;Persons;Phase;Plasma;pre-clinical;prevent;Process;programs;prospective;Prospective Studies;Proteomics;psychologic;Reporting;Research;Research Personnel;Research Project Grants;resilience;Role;Sampling;Sensory impairment;Sleep disturbances;Stratification;Technology;Testing;Thigh structure

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Early Markers of Alzheimer Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Estrogen;Mental Health;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

PROJECT_TERMS: active method;Adverse effects;Affect;Affective;Age;Air Pollution;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-Protein;Ancillary Study;Apolipoprotein E;apolipoprotein E-4;Area;Biological;Biological Assay;Biological Markers;Biology;blood-based biomarker;Brain;brain magnetic resonance imaging;California;CCL3 gene;Characteristics;clinical risk;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive testing;cohort;Cohort Studies;Conjugated Equine Estrogens;COVID-19 pandemic;critical period;CXCL10 gene;Data;Dementia;dementia risk;depressive symptoms;design;Development;Diet;Enrollment;Epigenetic Process;Evaluation;exosome;experience;follow-up;Future;Genetic;Genetic Risk;Genotype;Health;Heart Diseases;Hippocampus;hormone therapy;human old age (65+);Hysterectomy;Image;Immune;Impaired cognition;Individual;Inflammation;Inflammatory;Insulin Resistance;Investigation;ischemic lesion;ITGA11 gene;late life;Life;Long-Term Effects;Manuscripts;Measures;Medical;Medroxyprogesterone 17-Acetate;Memory;metabolomics;Methodology;mild cognitive impairment;negative affect;Nerve Degeneration;neuropathology;novel;Outcome;Paper;Participant;Particulate;Pattern;Perimenopause;Pharmaceutical Preparations;Placebos;Plasma;Post-Menopausal Hormone Replacement Therapy;Postmenopause;primary outcome;Probability;Proteins;Proteomics;Publishing;Randomized;randomized placebo-controlled clinical trial;remote assessment;Reporting;Research Personnel;Research Project Grants;resilience;Risk;risk variant;Site;social factors;Stroke;Subgroup;tau Proteins;Telephone;Testing;Time;transcription factor NF-AT c3;treatment effect;trend;Universities;Uterus;verbal;Woman;Women's Group;Women's Health;Women's study;Women's trial

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Women's Health Initiative Memory Study Extension: Alzheimer's Disease and Related Dementia, Cognitive Decline and Resilience