NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BELLEFONTE

ORG_NAME: ACTUATED MEDICAL, INC.

PHR: Project Narrative: Relevance – Age related cognitive decline creates substantial emotional and financial burden as well as reduced quality of life for patients and their families. Better tools are needed for study of these conditions in preclinical models. Implanted devices generate a chronic inflammatory state caused by vascular perforation and crushing of brain tissue which leads to encapsulation of the implanted device by scar tissue and loss of neural density. This SBIR project develops the Optical Neuroscience Insertion Tool (ONIT) for reduced insertion force and tissue damage during placement of optical imaging systems (fiber optic cannula, GRIN lenses) in preclinical studies.

PI_NAMEs: GHERES, KYLE WILLIAM (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: Academic skills;Acute;age related changes;Age-associated memory impairment;Aging;aging related;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease related dementia;Area;aspirate;attenuation;Award;Axon;Blood Vessels;brain tissue;Businesses;Cannulas;care costs;Central Nervous System;Certification;Chronic;Cicatrix;clinical translation;clinically relevant;Cognitive aging;commercialization;comparison control;Computers;Coupled;Dementia;Demyelinations;density;design;Development;Device or Instrument Development;Devices;Diameter;Disease;Doctor of Philosophy;Electrodes;Emotional;Encapsulated;experience;Family;Fiber;Fiber Optics;Financial Hardship;Freezing;Geometry;Glial Fibrillary Acidic Protein;Goals;grasp;Head;Histologic;Human;Image;Imaging Device;imaging system;Immersion;Impaired cognition;Implant;implantable device;implantation;improved;improved outcome;in vivo;Industrialization;Inflammation;Inflammatory;innovation;Investigation;Investments;Legal patent;lens;Light;light weight;Marketing;Measures;Mechanics;Medical;Medical Device;Medical Research;Mentors;Methodology;Methods;Microscope;Monitor;Morphology;Motion;Motor;multiphoton microscopy;Needles;Nerve Degeneration;neural;neural implant;Neurodegenerative Disorders;neuroimaging;neuronal excitability;Neurons;Neurosciences;Noise;operation;Operative Surgical Procedures;optical imaging;Optics;Patient-Focused Outcomes;Patients;Penetration;Perforation;Peripheral;Phase;Photometry;Postdoctoral Fellow;pre-clinical;Pre-Clinical Model;preclinical study;pressure;programs;Public Health;Puncture procedure;Quality of life;Research;research and development;Research Personnel;Resources;Rodent;Rodent Model;safety testing;Sales;Signal Transduction;Silicon;Small Business Innovation Research Grant;Speed;Surface;System;Technology;Testing;Thinness;Tissue Model;Tissues;tool;Translating;Ultrasonic Transducer;Ultrasonics;United States National Institutes of Health;Vacuum;verification and validation;Work

PROJECT_TITLE: Diversity Supplement for Development of an Oscillated Insertion tool to Eliminate Surgically Induced Neurodegeneration for Optical Neuroimaging of Cognitive Aging and Dementia


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Data Science;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Substance Misuse

ORG_CITY: UNIVERSITY

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MISSISSIPPI

ORG_STATE: MS

PHR: PROJECT NARRATIVE The proposed program addresses a significant gap by developing and implementing a novel model to train undergraduate and graduate students in applying data science methods for addiction research at major universities in Mississippi. The program integrates five components (webinars, summer academies, symposiums, a research lab, and an e-learning platform) innovatively to create a progressive learning pathway with a sustainable mechanism, first targeting campus-wide audiences for raising awareness and fostering interest and then offering students hands-on training and mentored research experiences. This program emphasizes engaging underrepresented students to promote a diverse data science workforce for addiction research.

PI_NAMEs: ZHANG, SAIJUN  (contact)

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: Academy;Acceleration;addiction;Address;Applications Grants;Artificial Intelligence;Awareness;Biometry;Collaborations;computer science;Data;Data Science;Data Scientist;Dedications;design;Development;Discipline;Discipline of Nursing;diverse data;Diverse Workforce;E-learning;Education;Educational Curriculum;Ensure;Evaluation;evidence base;Evolution;experience;Faculty;Fostering;graduate student;Health;Historically Black Colleges and Universities;Human;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;interest;Learning;Machine Learning;machine learning method;Medical center;Mentors;Mentorship;Methods;Mississippi;Modeling;multimodality;novel;Outcome;Participant;Pathway interactions;Pharmacy facility;Population Heterogeneity;Process;Program Sustainability;programs;Public Health;Publications;recruit;Research;Research Personnel;Research Proposals;Series;Services;Social Work;Students;symposium;Techniques;Training;Training Programs;trend;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;web site;webinar

PROJECT_TITLE: A Multimodal and Interdisciplinary Data Science Training Program to Enhance a Diverse Workforce for Addiction Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SXC-N (A1)]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: LOUISVILLE

ORG_NAME: INFLAMED, INC.

ORG_STATE: KY

PHR: Narrative: In our preliminary studies, we have shown promising results to treat Alzheimer’s disease (AD) in animal models by inhibiting complement pathways with humanized recombinant Vaccinia Virus Complement Control Protein (hrVCP). This project will carry out characterizing a large scale of high quality hrVCP in pre-formulation saline solution that will be then tested in AD animal models for validation of our earlier results by an independent CRO laboratory so that we will be able to seek additional funds from governments and private investors pre-clinical and then clinical studies in animals and humans. If successful, it will contribute to an intervention for AD.

PI_NAMEs: ZHOU, JIANHUA  (contact)

PROJECT_TERMS: Achievement;Aducanumab;Age;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Amyloid deposition;Amyloid Proteins;Animal Disease Models;Animal Model;Animals;Apolipoprotein E;apolipoprotein E-4;APP-PS1;Award;Binding;Bone Marrow;Brain;Carcinogens;Cardiotoxicity;Cause of Death;Cells;Characteristics;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Complement;Complement Activation;complement C3 precursor;complement pathway;complement system;Contractor;cost;Data;Dementia;Deposition;Development;Disease;disease model;disorder control;economic impact;Effectiveness;efficacy evaluation;efficacy testing;efficacy validation;Endotoxins;Event;extracellular;FDA approved;Formulation;Funding;Genetic Predisposition to Disease;genetic regulatory protein;Genotype;Goals;Government;Grant;Heavy Metals;Hepatotoxicity;Human;improved;improved outcome;In Vitro;Inflammation;Inflammation Mediators;Inflammatory;Injections;Insurance;Intervention;Laboratories;Legal patent;manufacture;Mediating;Memory Loss;Modeling;mouse model;Mus;Mutagens;Nerve Degeneration;neuroinflammation;Nose;Outcome;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phase 1 study;phase 2 study;Physicians;Population;Poxviridae;pre-clinical;preclinical study;prevent;Privatization;Production;Proteins;Publishing;Qualifying;Regulation;Resources;Rodent;Role;Safety;safety assessment;safety study;Saline;Senile Plaques;Small Business Innovation Research Grant;Social Impacts;Spinal cord injury;stem cell derived tissues;Sterility;synergism;Testing;Therapeutic;Therapeutic Uses;Time;Tissues;Toxic effect;Toxin;Traumatic Brain Injury;Vaccinia virus;Vaccinia virus complement-control protein;Vaccinia Virus Study;Validation

PROJECT_TITLE: Treatment with hrVCP of ApoE4 genetic predisposition to AD by controlling complement mediated neuroinflammation


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative The proposed project will use electronic health record data to assess the prevalence and incidence of diabetes mellitus among children and adolescents, overall and by diabetes type and patient sociodemographic and clinical characteristics. Data will come from PEDSnet, a national pediatric clinical research network that has transformed EHR data to a common data model for over 6.5 million children. The study will address the Healthy People 2020 diabetes-specific objectives by providing new, detailed, and timely information on the pediatric epidemiology of diabetes mellitus in the US.

PI_NAMEs: BAILEY, CHARLES ;FORREST, CHRISTOPHER B (contact)

PROJECT_TITLE: DP20-001 Using EHR Data to Evaluate the Burden of Diabetes Mellitus in a National Network of Children's Hospital Health Systems


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: Project Narrative Heart failure is the inability of the heart to pump adequately to supply the body with sufficient oxygen to meet its needs, and heart failure is a leading cause of death in the United States, the veteran population included. Of the 50,000 individuals diagnosed with heart failure each year, 70% of these patients have heart failure due to a previous heart attack (myocardial infarction; MI). The main objective of this grant is to use a mouse MI model to understand how one of the white blood cell types, the neutrophil, influences scar formation by regulating the wound healing response, particularly the inflammatory and reparative components.

PI_NAMEs: LINDSEY, MERRY L. (contact)

PROJECT_TERMS: Affect;American;Anti-Inflammatory Agents;aptamer;Cathepsins;Cause of Death;Cell Physiology;cell type;Cells;Cicatrix;Congestive Heart Failure;Coupled;Data;Death Rate;Deposition;Development;Diagnosis;Discipline;Evaluation;Evolution;Extracellular Matrix;Fibrinogen;Fibroblasts;Fibronectins;Flow Cytometry;Funding;Galectin 3;Gelatinase B;Goals;Grant;Heart;Heart failure;Heterogeneity;In Vitro;in vitro Assay;Individual;Infarction;Infiltration;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;innovation;Interleukin-4;Intervention;Investigation;Knowledge;Left Ventricular Remodeling;Left ventricular structure;Leukocytes;Macrophage;Maps;Matrix Metalloproteinases;Mediator;military veteran;Modeling;Molecular;Monitor;Mus;Myocardial Infarction;necrotic tissue;neutrophil;new therapeutic target;novel;Outcome;Oxygen;Patients;Pattern;Peptide Hydrolases;Phase;Phenotype;prevent;Principal Component Analysis;Proteins;Proteomics;Publications;Publishing;Pump;repaired;Reporting;Resolution;response;Role;Testing;Therapeutic Intervention;thrombospondin 2;Time;Tissues;tool;United States;wound healing

PROJECT_TITLE: Neutrophil Polarization Following Myocardial Infarction


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: We propose a mixed methods study to evaluate the impact of VA-financed community care for Veterans with advanced kidney disease, and to identify subgroups within this population most likely to benefit and most likely to be harmed by receipt of nephrology care in the community. These patients comprise a high-cost high-needs segment of the Veteran population facing a critical health and care transition (onset of end-stage renal disease). The work we here propose is highly relevant to the VA mission (it will directly address three VA HSR&D priority areas), timely (the VA MISSION Act recently received strong bipartisan support in both the House and the Senate), and will directly inform evolving VA policy around the provision of community care for Veterans.

PI_NAMEs: O'HARE, ANN M. (contact)

PROJECT_TERMS: Address;Area;care coordination;care fragmentation;care providers;Caring;Characteristics;Clinical;Clinical Data;Communities;Community Financing;Community Healthcare;Continuity of Patient Care;cost;design;Dialysis procedure;early experience;Eligibility Determination;End stage renal failure;Evaluation;experience;Fees;Fistula;Health;health care availability;Health Promotion;Health Services Accessibility;Healthcare Systems;Hemodialysis;Heterogeneity;Hospitalization;improved;Incidence;Intervention;Interview;Kidney;Kidney Diseases;Kidney Transplantation;Learning;Maintenance;Managed Care;Measures;Medical;Medical center;Methods;military veteran;Mission;mortality;Nephrology;Outcome;Outpatients;Patient Care;patient population;Patient-Centered Care;Patients;Peritoneal Dialysis;Policies;poor health outcome;Population;Preparation;Process;process improvement;programs;Provider;Quality of Care;Readiness;Recording of previous events;Research Personnel;Resources;Shapes;shared decision making;Specialist;Structure;Subgroup;System;Transplantation;Variant;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Optimizing the value of community care for Veterans with advanced kidney disease

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Impaired metabolism is known to be strongly associated with a metabolically induced inflammation with an increase in white blood cells called myeloid cells (monocytes/macrophages) in animal models and studies in adults. However, risk for these diseases and inflammatory responses to obesity are not uniform and further identification of who is at risk could potentially prevent disease manifestation. This proposal seeks to evaluate if circulating monocyte gene expression and phenotype can characterize adolescents with obesity with a risk for meta-inflammation and if nutritional fatty acids can modify this risk.

PI_NAMEs: SINGER, KANAKADURGA  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Adolescent;Adolescent obesity;Adult;adult obesity;Animal Model;Animals;Antigen Presentation;Automobile Driving;boys;Cardiovascular Diseases;CD14 gene;Cell Maturation;Cells;Child;Childhood;Clinical;Clinical Research;cytokine;Data;Diabetes Mellitus;diabetes risk;Diet;Dietary Fatty Acid;Disease;disorder risk;Eicosanoids;Ensure;Evaluation;fatty acid oxidation;Fatty Acids;Female;Female Adolescents;Flow Cytometry;Functional disorder;Future;gender dysphoria;gender minority youth;Gene Expression;girls;Glycosylated hemoglobin A;Goals;Gonadal Steroid Hormones;Hematopoietic;Heterogeneity;high risk;Human;Hypertriglyceridemia;Immune;Impairment;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;Intervention;ITGAX gene;Knowledge;leukocyte activation;Leukocytes;Life;Link;Lipids;Lipopolysaccharides;Lymphocyte;Macrophage;male;Male Adolescents;Measures;men;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Modeling;monocyte;Mus;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;Myelopoiesis;Non-Insulin-Dependent Diabetes Mellitus;Nutritional;Obesity;obesogenic;Outcome;Pathway interactions;Phenotype;Population;Prevalence;prevent;Production;progenitor;Prostaglandins;Puberty;recruit;Reproducibility;response;Risk;Risk Factors;Role;Saturated Fatty Acids;Sorting;stem cells;Thinness;Tissues;TLR4 gene;trafficking;transcriptome sequencing;transcriptomics;Translations;United States;uptake;Vulnerable Populations;Weight;Woman

PROJECT_TITLE: The role of circulating meta-inflammatory monocytes in adolescent insulin resistance

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: This project develops new methods to analyze the structures of flexible proteins. It applies those methods to bacterial virulence proteins and to protein assemblies involved in neurotransmission. The knowledge gained will enable new targeted drug delivery strategies and a better understanding of how neurotransmission is regulated.

PI_NAMEs: KASSON, PETER M (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Affect;Affinity;Area;arm;Automobile Driving;Binding;Binding Proteins;Biological;cell growth regulation;Complex;Computer Analysis;Computer Models;Data;design;Development;Drug Delivery Systems;Equilibrium;Event;Exocytosis;experimental study;flexibility;Fluorescence Resonance Energy Transfer;Hybrids;improved;insight;Invaded;Joints;Knowledge;Label;Measurement;Measures;Membrane;Methodological Studies;Methodology;Methods;Modeling;Molecular Conformation;molecular dynamics;molecular recognition;nanomolar;Neisseria;Neurons;neurotransmission;new therapeutic target;pathogen;Pathogenesis;Physiological;Play;Population;Population Distributions;Process;Protein Conformation;Proteins;receptor;Regulation;Relaxation;Resolution;restraint;Role;Sampling;simulation;single-molecule FRET;Site;SNAP receptor;Source;Spectrum Analysis;Structure;Synapses;syntaxin;Techniques;Testing;Time;Virulence;Work

PROJECT_TITLE: Simulation-guided spectroscopy and refinement of heterogenous conformational ensembles

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Primary Health Care;Social Determinants of Health;Suicide

ORG_CITY: HADLEY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: PROJECT NARRATIVE The prevalence of behavioral health disorders has climbed steadily among children in the U.S. over the past decade, disproportionately affecting children in lower income and minoritized populations including sexual and gender minorities (SGM). Access to appropriate diagnostic and treatment services can also be particularly challenging for these populations, but Medicaid accountable care organizations (ACOs) have the potential to address gaps in behavioral health care for children in these populations. This supplement enhances our parent study examining the effects of Medicaid ACOs on pediatric BH quality, utilization, outcomes, and disparities by augmenting our analysis of the experience of SGM youth.

PI_NAMEs: GEISSLER, KIMBERLEY LYNN H;GOFF, SARAH L (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: access disparities;accountable care organization;Address;Administrative Supplement;adverse childhood events;Affect;Age;Anxiety;Behavior;behavior influence;behavioral health;beneficiary;care coordination;Caring;Characteristics;Child;Child health care;Childhood;community based service;Consultations;COVID-19;Data;Data Collection;Diagnosis;Diagnostic Services;Disease;Disparity;ethnic minority population;Evidence based treatment;experience;Feeling suicidal;Funding;Future;Gender Identity;gender minority group;gender minority youth;Health;health care disparity;health care quality;Health Insurance;health organization;Health Personnel;Healthcare;Heterogeneity;high risk;high risk population;improved;Incentives;innovation;insight;Insurance Coverage;interest;Intervention;Interview;Low income;low socioeconomic status;Medicaid;member;Mental Depression;Minority Groups;National Institute of Mental Health;Organizational Models;Outcome;parent grant;Parents;Participant;Patients;peer;Population;population health;Prevalence;primary care provider;primary care setting;Privatization;programs;Psychiatry;Quality of Care;racial minority population;Reporting;Research;response;Risk;Role;Sample Size;Sampling;Self-Injurious Behavior;Services;Sex Orientation;Sexual and Gender Minorities;sexual minority group;sexual minority youth;social health determinants;social stigma;Suicide;Surveys;Telephone;therapy development;Thinking;treatment services;Vulnerable Populations;Youth

PROJECT_TITLE: Effect of Medicaid Accountable Care Organizations on Behavioral Health Care Quality and Outcomes for Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(90)-S]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative The Oklahoma INBRE (OK-INBRE) program supports biomedical research and allows researchers in Oklahoma to be more competitive for federal research funding that leads to better medical diagnostics and novel therapies to treat human disease. OK-INBRE also enhances the pipeline of undergraduate and graduate students choosing careers in biomedical research to ensure there will be well-trained biomedical scientists in Oklahoma and throughout the country for future generations. The overall goal of the OK-INBRE program is to support faculty research and research mentoring, student participation in research, and enhancement of institutional research infrastructure.

PI_NAMEs: AKINS, DARRIN R. (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Accreditation;Administrative Supplement;American Indians;Arkansas;Award;Basic Science;Bioinformatics;Biomedical Research;biomedical scientist;Caliber;career;career development;clinical diagnostics;cohort;Collaborations;college;Communication;Communities;community college;computerized tools;Core Facility;Country;Development;Education;education resources;Educational Curriculum;Educational process of instructing;Educational workshop;Eligibility Determination;Ensure;Equipment;experience;Faculty;faculty research;faculty support;Foundations;Funding;Future Generations;Goals;graduate student;Grant;Growth and Development function;hands on research;Health;Health Status;higher education;Historically Black Colleges and Universities;human disease;improved;Infrastructure;Institution;institutional capacity;Instruction;Laboratories;Leadership;Mentors;multidisciplinary;next generation;novel therapeutics;Oklahoma;outreach;Peer Review Grants;Pilot Projects;Play;Process;Productivity;Program Research Project Grants;programs;Proteomics;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Role;Science;Services;student participation;student training;Students;success;Technology;Training;tribal college;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Supplement to the Existing Oklahoma INBRE Award


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: DAVIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research focuses on understanding how plants regulate the strength, duration and specificity of immune responses. Due to significant similarity in immune perception between plants and vertebrates, we anticipate experimental insights will broadly enhance our understanding of immune perception and signaling.

PI_NAMEs: COAKER, GITTA LAUREL (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Animals;Binding;Cells;Cysteine;Data;defense response;Exhibits;Germ Lines;Immune;Immune response;Immune signaling;Immunologic Receptors;Innate Immune Response;Innate Immune System;insight;Leucine-Rich Repeat;Mediating;next generation;Nucleotides;Organ;pathogen;pathogenic bacteria;Pattern recognition receptor;Perception;Phosphotransferases;Plant Leaves;Plants;Post-Translational Protein Processing;Protein Kinase;receptor;Regulation;Research;response;Role;Scientist;Signal Transduction;Specificity;Surface;Training;Vertebrates

PROJECT_TITLE: Immune perception of bacterial pathogens in plants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Maternal Health;Networking and Information Technology R&D (NITRD);Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH Infants and birthing people from communities of color experience the highest rates of mortality and morbidity in the United States due to the interacting effects of systemic racism, further exacerbated among sexual and gender minority (SGM) parents of color by stress due being part of a multiply marginalized community. Whereas popular programs for minoritized populations involve resource-intensive home visits or non- personalized health information materials, we propose extensions of the Rosie the chatbot software that addresses both possible limitations by representing a scalable tool that can have widespread reach across geographies and is personalized and responsive to an individual's specific informational needs. Results from our project can be utilized to inform system-wide and local strategies to reduce health disparities by lower barriers to access to timely and verified health information.

PI_NAMEs: APARICIO, ELIZABETH MARIE;NGUYEN, THU  (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: acceptability and feasibility;Address;Advocate;Age;Android;Area;Artificial Intelligence;Birth;care outcomes;chatbot;Child Health;Child Rearing;Client;Color;Communication;Communities;community engagement process;community organizations;computer science;Computer software;cost;cost effective;cultural competence;Databases;Date of birth;Death Rate;design;Devices;Discrimination;disparity reduction;District of Columbia;Education;Ensure;ethnic disparity;experience;Feedback;flexibility;gender minority community;gender minority health;gender minority status;General Population;Geography;graphical user interface;Health;Healthcare;Home visitation;Homophobia;Housing;improved;Individual;Infant;Infant Care;Infant Health;Infant Mortality;infant outcome;Institutional Racism;Internet;Knowledge;marginalized community;Maryland;Maternal and Child Health;maternal outcome;Medical;Minority Groups;mobile application;Modeling;Morbidity - disease rate;mortality;Mothers;Notification;Occupations;open source;parent grant;Parents;Participant;people of color;personalized approach;Persons;postnatal;postpartum health;Postpartum Period;Pregnancy;pregnant;Pregnant Women;prenatal;programs;Provider;Public Health;Quality of life;racial disparity;Reduce health disparities;Research;Research Personnel;Resources;response;Retrieval;Sexual and Gender Minorities;social health determinants;Software Engineering;Source;Stress;System;Technology;Text Messaging;Time;tool;transphobia;United States;Variant;Virginia;Visual;Vulnerable Populations

PROJECT_TITLE: Rosie the Chatbot: Leveraging Automated and Personalized Health Information Communication to Reduce Disparities in Maternal and Child Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(09)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Cancer;Liver Disease;Organ Transplantation;Orphan Drug;Rare Diseases;Transplantation

ORG_CITY: Raleigh

ORG_NAME: GLYCAN THERAPEUTICS CORPORATION

ORG_STATE: NC

PHR: Project Narrative For some liver cancer patients a liver transplantation represents a cure, yet this procedure involves ischemia reperfusion injury which effects graft function and leads to tumor recurrence. Glycan Therapeutics in collaboration with the University of North Carolina Chapel Hill, will investigate the use of dekaparin to reduce transplant associated ischemia reperfusion injury. The success of this project will offer a way to mitigate a common complication which has no existing therapeutics available.

PI_NAMEs: ARNOLD, KATELYN  (contact);PAGADALA, VIJAYAKANTH

PROGRAM_OFFICER_NAME: TRIPURANI, SWAMY KRISHNA

PROJECT_TERMS: adverse outcome;animal data;Anions;Anti-Inflammatory Agents;Anticoagulants;Bile fluid;Biliary;Biological Markers;Biological Response Modifiers;Blood Circulation;Blood flow;cancer recurrence;Chromatography;Clinical;Coagulation Process;cohort;Collaborations;Communication;Complication;Cryopreservation;curative treatments;Data;Development;Diagnosis;Disease;Dose;effective therapy;Effectiveness;experience;experimental study;Flushing;Future;Glycocalyx;Goals;graft function;Heart Arrest;Heparin;Histology;Hypoxia;improved;in vivo;in vivo Model;Infiltration;Inflammation;inflammatory marker;Innovation Corps;Ischemia;ischemic injury;Legal patent;Letters;Liver;liver cancer patient;liver function;liver injury;liver ischemia;Liver neoplasms;liver preservation;liver transplantation;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;natural hypothermia;Neoplasm Circulating Cells;neutrophil;Nitrogen Dioxide;North Carolina;novel;Oligosaccharides;Organ;Organ Preservation;Organ Procurements;Organ Transplantation;Orphan;Orphan Drugs;Outcome;Patients;Perfusion;pharmacokinetics and pharmacodynamics;Phase;Polysaccharides;Portal Pressure;post-transplant;pre-clinical;Predisposition;preservation;Primary carcinoma of the liver cells;Procedures;Process;product development;Production;Publishing;Pump;Rattus;Recommendation;Recurrent tumor;Recycling;Regional Perfusion;Regulatory Pathway;Reperfusion Injury;Reperfusion Therapy;Retrospective Studies;Risk Reduction;Small Business Technology Transfer Research;Structure;success;Surgical complication;Surgical Models;Technology;Testing;Therapeutic;Thrombophilia;Time;Tissues;transplant model;Transplantation;Universities;Warm Ischemia

PROJECT_TITLE: National I-Corps: Development of synthetic heparin to protect liver graft from ischemia reperfusion injury during transplantation


NIH_SPENDING_CATS: Hematology;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Narrative: Using in vivo models of G-CSF and phlebotomy we will define the cellular mechanisms through which different bones differentially responds to stress. We will demonstrate that differences in the cell composition and shape of the microenvironment can profoundly impact how each bone responds to stress. Together this will provide proof of principle for bone-specific manipulations for precise control of hematopoiesis in vivo.

PI_NAMEs: LUCAS, DANIEL  (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Aftercare;Anatomy;Automobile Driving;beta Thalassemia;biological adaptation to stress;Biological Assay;bone;bone cell;Bone Formation Inhibition;bone loss;Bone Marrow;Cell Count;Cells;CFU-E;Circulation;Clinical;cranium;CSF3 gene;Disease;Erythrocytes;Erythroid;Erythropoiesis;Erythropoietin;experimental study;Femur;Frequencies;Genetic Models;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Mobilization;Hematopoietic stem cells;Hemorrhage;Heterogeneity;Image;imaging approach;In Situ;in vivo;in vivo Model;Link;long bone;Macrophage;Marrow;Mediating;Methods;Modeling;mouse model;Mus;Nature;neutrophil;novel;Osteoclasts;Osteogenesis;Output;Population;prevent;Production;progenitor;Proliferating;Radiology Specialty;response;Rest;Role;Shapes;skeletal;Skeleton;stem cell expansion;Sternum;Stress;substantia spongiosa;Testing;tibia;Venous blood sampling;Visualization

PROJECT_TITLE: Skeletal heterogeneity of bone marrow stress responses.

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Drug addiction is a disorder of the brain that puts a heavy burden on the society. Studies proposed herein are aimed at developing means for brain circuit selective manipuations with opioid receptor signaling aimed at dissociating analgesic effects of opioid drugs from the development of dependence. It is anticipated that the results will facilitate the design of novel strategies for the treatment of drug addiction addressing a critical need to combat growing opioid abuse epidemic.

PI_NAMEs: MARTEMYANOV, KIRILL A. (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Absence of pain sensation;addiction;Addictive Behavior;Address;Analgesics;Anhedonia;Animals;antagonist;behavior influence;behavior test;Behavioral;Behavioral Assay;behavioral response;Biological Assay;Biology;Brain;Brain Diseases;Caenorhabditis elegans;Cells;Chemicals;Cholesterol;Clinical;clinically significant;combat;conditioned place preference;Data;Dependence;design;Development;Dissociation;Divorce;Drug Addiction;drug development;Drug Kinetics;drug of abuse;Electrophysiology (science);Elements;Epidemic;Euphoria;Event;experimental study;Exposure to;Family;FDA approved;follow-up;G-Protein-Coupled Receptors;Genes;Genetic Screening;Goals;high throughput screening;in vivo;in vivo evaluation;inhibitor;innovation;Investigation;Knock-out;Knockout Mice;Lead;Mediating;member;Membrane;Molecular;mu opioid receptors;Mus;neural circuit;Neurons;neuroregulation;Nociception;novel;novel strategies;opiate tolerance;Opioid;opioid abuse;Opioid agonist;Opioid Analgesics;Opioid Receptor;optical imaging;Optics;Orphan;Overdose;Pain management;pain model;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacologic Actions;Pharmacology;Positioning Attribute;prevent;Property;Proteins;Reaction;receptor;Receptor Signaling;Regulation;Relapse;Research;Resolution;response;Rewards;Rodent Model;Role;scaffold;screening;Self Administration;Series;side effect;Signal Transduction;Slice;small molecule;small molecule inhibitor;Societies;Specificity;Structure;System;Tail;Testing;Time;tool;Toxicology;trafficking;treatment strategy;Withdrawal

PROJECT_TITLE: Pharmacological targeting of nascent modulators of opioid signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 IXR-N (A2)]


NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: We will perform first systematic test of associations between maternal diagnoses around pregnancy and the risk of ASD in offspring. In order to understand whether the observed associations between maternal diagnoses and ASD arise due to genetic or non-genetic mechanisms, we will then analyze family and molecular genetic data available for this large cohort. Our goal is to identify potential novel risk factors for ASD, close important gaps in the knowledge about the etiology of ASD, and elucidate possible pathways to prevention.

PI_NAMEs: JANECKA, MAGDALENA  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Accounting;Affect;American;autism spectrum disorder;autistic children;Birth;Brothers;California;Child;Circulation;cohort;comorbidity;Coupled;Data;Data Set;Data Sources;Denmark;design;Development;Diabetes Mellitus;Diagnosis;Disease;disorder risk;Early identification;Ensure;Environmental Risk Factor;Epidemiology;Etiology;experience;Exposure to;Extended Family;Family;family genetics;Family Relationship;Female;Fetus;Genetic;genetic pedigree;Genetic Risk;Goals;Health Status;high risk;indexing;Individual;Infection;innovation;insight;Intellectual functioning disability;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Intervention;Knowledge;Link;Live Birth;male;Maps;Maternal Exposure;Maternal Health;Medical;Medical Records;Mental Depression;Methodology;modifiable risk;Molecular Genetics;Mothers;non-genetic;novel;offspring;Outcome;Output;Parents;Partner in relationship;Pathway interactions;Permeability;Placenta;polygenic risk score;population based;Pregnancy;prenatal;Prevention;Preventive;Process;Public Health;recurrent infection;Registries;response;Risk;Risk Factors;Sampling;sex;Sister;Testing;Time;transmission process;Vertical Disease Transmission;Woman;Work

PROJECT_TITLE: Maternal health in pregnancy and autism risk - genetic and non-genetic mechanisms

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Mitochondria are the site of essential cellular processes such as metabolism and apoptosis (controlled cell death), which are often misregulated in cancer and neurodegenerative diseases. Proper mitochondrial function depends on a robust quality control system to remove old, damaged, or mislocalized proteins. Here, I propose experiments to test how mitochondrial protein quality control systems function, which could lead to new therapeutic approaches to cancer and neurodegenerative diseases.

PI_NAMEs: WOHLEVER, MATTHEW LEE (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Affect;Aging;Apoptosis;Apoptotic;ATP Hydrolysis;ATP phosphohydrolase;Biological Assay;Biology;Cardiovascular Diseases;Cell Death;Cell Physiology;Cessation of life;conditioned fear;Encephalopathies;Excision;experimental study;Genetic;Health;Homeostasis;Homologous Gene;Human;Impairment;In Vitro;insight;Investigation;Lead;Link;Lipid Bilayers;Malignant Neoplasms;Mediating;Membrane;Membrane Fluidity;Membrane Proteins;Metabolism;Mitochondria;mitochondrial membrane;Mitochondrial Proteins;Molecular;Mutation;Neurodegenerative Disorders;novel therapeutic intervention;Outer Mitochondrial Membrane;Oxidative Phosphorylation;Physiological;Play;Process;Proteins;Proteome;Proteomics;proteostasis;Quality Control;reconstitution;Regulation;Role;Site;Structure;System;Testing;Universities;Utah;Work

PROJECT_TITLE: Mechanistic Investigation of Proteostasis at the Outer Mitochondrial Membrane

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Substance Misuse

ORG_CITY: Chicago

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Youth in the U.S. legal system experience stark behavioral health disparities related to substance use and sexual health compared with peers who have not been arrested, yet they are among those in the country who are least likely to receive effective health promotion services. Low emotion regulation appears to be a common mechanism underpinning these health disparities and it can be improved via mindfulness meditation. This study will leverage strong community partnerships, mobile health (mHealth) technology, and implementation science to test the effectiveness and implementation of a meditation app developed with and for youth on probation to address substance use, sexual health, and emotion regulation.

PI_NAMEs: KENDALL, ASHLEY D. (contact)

PROGRAM_OFFICER_NAME: MITCHELL, SHANNON GWIN

PROJECT_TERMS: acceptability and feasibility;adaptive intervention;addiction;Address;Adherence;Area;Attention;behavioral health;Chicago;Collaborations;Communities;community partnership;comparative effectiveness trial;cooking;Country;County;Data;design;Development;Disparity;Ecological momentary assessment;Educational process of instructing;Effectiveness;effectiveness testing;effectiveness-implementation RCT;emotion regulation;Evidence based practice;experience;Face;feasibility testing;Focus Groups;Funding;Future;Gender;Goals;Health;health disparity;Health Promotion;Health Technology;HIV;Hybrids;Impairment;implementation outcomes;implementation science;implementation strategy;implementation/effectiveness;improved;Individual;infection risk;interest;Intervention;Interview;juvenile justice system;Leadership;Legal;Legal system;Mediating;Meditation;mHealth;mindfulness meditation;minority communities;National Institute of Drug Abuse;Outcome;peer;Persons;Population;probation;programs;Public Health;Randomized;recidivism;reduced substance use;Reporting;response;Risk;Running;Services;sex;Sex Behavior;Sexual Health;sexual risk behavior;Sexually Transmitted Diseases;Signal Transduction;smartphone application;Structure;substance use;Testing;therapy design;Time;tool;Translational Research;trustworthiness;Work;Youth

PROJECT_TITLE: Effectiveness and Implementation of a Meditation App addressing Substance Use, Sexual Health, and Emotion Regulation among Legal-Involved Youth

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: Streptococcus pneumoniae remains a leading cause of bacterial pneumonia and death due to infectious diseases worldwide despite the use of two approved vaccines targeting the serotypically diverse capsular polysaccharide. The infection rate remains high, especially in older adults, primarily due to infection with serotypes not included in current vaccines, and treatment options can be limited as there has been a rise in antibiotic resistance among non-vaccine serotypes. The research described in this R01 proposal will determine the protective efficacy and underlying structural and mechanistic correlates of protection of human monoclonal antibodies to highly conserved pneumococcal surface proteins.

PI_NAMEs: MOUSA, JARROD  (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acute;Address;Adhesions;Agglutination;Antibiotic Resistance;Antibodies;Antigen Targeting;Antigens;Asthma;B-Lymphocytes;Bacteremia;Bacteria;Bacterial Pneumonia;Binding;Cardiovascular Diseases;Cells;Cessation of life;Chronic Obstructive Pulmonary Disease;Clinical Trials;Communicable Diseases;Complement;Coupled;Cryoelectron Microscopy;Data;Death Rate;Deposition;Development;Diabetes Mellitus;Disease Management;Encapsulated;Epitopes;Exhibits;Failure;Frequencies;Growth;high risk population;HIV;Human;human monoclonal antibodies;Immunologics;improved;In Vitro;in vivo;Incidence;Individual;Infection;infection rate;infectious disease treatment;influenza infection;innovation;Interferometry;Invaded;Lung;Macrophage;Mediating;Membrane Proteins;Meningitis;Microbial Biofilms;Modeling;Monoclonal Antibodies;mouse model;Mus;Mutation;Nasopharynx;National Institute of Allergy and Infectious Disease;neutrophil;novel therapeutics;older adult;Otitis Media;pandemic influenza;pathogen;pathogenic bacteria;Pathway interactions;Pharmaceutical Preparations;Pneumococcal Colonization;Pneumococcal Infections;Pneumococcal Pneumonia;Pneumococcal vaccine;Pneumonia;Polysaccharides;prevent;Prevention;prophylactic;protective efficacy;Proteins;Protocols documentation;Readiness;Research;Role;Serotyping;Specificity;Streptococcus pneumoniae;structural determinants;synergism;Techniques;Therapeutic;United States National Institutes of Health;vaccine efficacy;Vaccines;Work;X-Ray Crystallography

PROJECT_TITLE: Epitope and mechanistic correlates of broadly protective human antibodies for pneumococcal infection

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Precision Medicine;Prevention;Social Determinants of Health;Women's Health Research

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE The goal of this administrative supplement is to identify social determinants of health (SDOH) affecting women (conditions in the environments where women are born, live, learn, work, play, and age) and how these intersect with biological sex and genetic variation to impact relationships between dental and systemic disease. We will utilize survey available through the All of Us Program Research Workbench to identify specific SDOH domains that are simultaneously identified with clinical and genetic data as most likely contributing to differences in the frequencies of select dental and systemic diseases. This study represents a major advance in the field and will provide critical information to develop a more comprehensive picture of individual and community-level factors underlying oral and systemic disease relationships affecting women in the United States.

PI_NAMEs: LETRA, ARIADNE M (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Address;Administrative Supplement;Affect;Age;All of Us Research Program;Animals;Behavioral;Biological;Biological Factors;biological sex;Birth;Censuses;Chronic;Clinical;Clinical Data;Communicable Diseases;community-level factor;Data;data integration;demographics;Dental;dental infection;Dental Records;Development;dimensional analysis;Disease;disease phenotype;Disproportionately impacts women;dysbiosis;Environment;environmental stressor;Epidemiology;epidemiology study;Ethnic Population;experience;Female;Frequencies;Gender;Genetic;Genetic study;genetic variant;Genetic Variation;genomic data;Genomics;Goals;Health;health care availability;health care service utilization;health data;health related quality of life;improved;Individual;Inflammatory;insight;Integration Host Factors;Learning;Life Style;Link;male;Medical;Medical Records;Medicine;men;microbial;Mouth Diseases;National Institute of Dental and Craniofacial Research;Oral;Oral health;Outcome;parent project;Participant;Pathogenesis;Pathway interactions;patient oriented;Pharmaceutical Preparations;Phenotype;phenotypic data;Play;Population;Population Heterogeneity;Positioning Attribute;Precipitating Factors;Predisposing Factor;Predisposition;Prevalence;Prevention strategy;programs;racial population;Reporting;Research;Severities;sex;Sex Differences;sex variable;social health determinants;social influence;Strategic Planning;Surveys;Systemic disease;Testing;Tooth Diseases;treatment strategy;United States;United States National Institutes of Health;Woman;Women's Health;Work

PROJECT_TITLE: Social determinants of health and its impact on the interconnectedness between dental and systemic disease in women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(51)-R]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Project Narrative We need better tools to predict the future distribution of and year-to-year variation in populations of the blacklegged tick, a key Lyme disease vector. Development of these tools is hampered because blacklegged tick populations are affected by stochastic extreme weather events which are poorly captured in current models. We will address this with a joint empirical-theoretical framework to develop better understanding of tick response to weather variation and extremes and a model structure to accommodate that understanding.

PI_NAMEs: FRANCKLYN, CHRISTOPHER S (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Address;Administrative Supplement;Affect;Air;Area;Arthropod Vectors;Bacteria;Behavior;Biology;Black-legged Tick;Borrelia burgdorferi;Centers of Research Excellence;Climate;climate change;Code;Collaborations;college;Computer Models;Data;Deer;Desiccation;Development;Disease Vectors;disorder risk;epidemiological model;Event;experience;Extinction;extreme weather;field study;Future;Geography;Humidity;Joints;Life Cycle Stages;life history;Lyme Disease;Maps;mathematical model;Measures;Microclimate;Modeling;Monitor;mortality;novel;novel strategies;Plant Leaves;Population;Population Dynamics;Precipitation;Probability;Process;Public Health;Research;Research Personnel;response;Series;Structure;System;Temperature;tick population;Tick-Borne Diseases;Ticks;Time;tool;tool development;undergraduate research experience;undergraduate student;United States;Variant;vector;Vector-transmitted infectious disease;Vermont;Weather;Work

PROJECT_TITLE: Vermont INBRE Administrative Supplement 2024 AWD 118


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: MINNEAPOLIS

ORG_NAME: CEROVATIONS, LLC

ORG_STATE: MN

PHR: Narrative The project will contribute to better outcomes for patients with traumatic brain injury, which is the leading cause of death and disability among young individuals.

PI_NAMEs: HOFMEISTER, JOE  (contact);MANLEY, GEOFFREY T;ODLAND, RICK ;OKONKWO, DAVID O

PROGRAM_OFFICER_NAME: FRANKOWSKI, MEGAN MICHELLE

PROJECT_TERMS: Air;Animal Experiments;Animals;Authorization documentation;Catheters;Cause of Death;Cerebral Edema;Cerebral Ventricles;Cerebrospinal Fluid;Clinical;Clinical Research;commercial launch;commercialization;Data;Devices;Diffusion;disability;Drainage procedure;Dryness;Economics;Edema;Enrollment;Excision;experience;Feasibility Studies;Fiber;first-in-human;Future;Gases;Hydrostatic Pressure;improved;Individual;innovation;Intervention;Marketing;Medical;Membrane;Morbidity - disease rate;Nervous System Trauma;Osmolalities;Osmosis;Osmotic Pressure;Pathway interactions;Patient-Focused Outcomes;Patients;Phase;pilot trial;Preclinical Testing;primary endpoint;Publishing;Randomized;Refractory;Reporting;Safety;safety assessment;safety study;Small Business Innovation Research Grant;standard of care;System;TBI Patients;Tissues;tool;Translational Research;Traumatic Brain Injury;Ventricular;Water;Water Movements;water vapor

PROJECT_TITLE: Pilot Clinical Study to Assess Safety and Efficacy of External Ventricular Drainage with Cerebrospinal Fluid Water Removal Osmotherapy for Traumatic Brain Injury-Induced Cerebral Edema


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Young transgender women (TGW) in Thailand face widespread stigma and discrimination. This discrimination may result from multiple marginalized identities including gender and sexual identity and perception of HIV status. “Intersectional stigma” may be one key barrier to HIV prevention and care (PrEP use, HIV testing). This project will develop and test a technology-delivered program designed to reduce HIV-related stigma and improve the use of HIV prevention services . If successful, the program could help young TGW in Thailand to live healthier lives and reduce risk for HIV.

PI_NAMEs: MACDONELL, KAREN ;PHANUPHAK, NITTAYA ;WANG, BO  (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Abbreviations;acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adherence;Adult;Affect;Age;aged;AIDS prevention;Asia;Awareness;Behavioral;Caring;Client;Clinic;community advisory board;Counseling;Country;Data;design;Development;Discrimination;Disproportionately impacts women;Dominican Republic;Drug usage;effective intervention;Effectiveness;efficacy trial;emerging adulthood;Employment;empowerment;Epidemic;Evidence based intervention;experience;Face;feasibility research;Focus Groups;Gender Identity;group intervention;Health Personnel;Health system;high risk behavior;HIV;HIV Infections;HIV risk;HIV Seronegativity;HIV Seroprevalence;Human immunodeficiency virus test;impression;improved;Infection;innovation;internalized stigma;Intervention;intervention refinement;Interview;marginalization;medication compliance;Mental Depression;Mental Health;mHealth;mhealth interventions;mobile computing;mobile delivery;Modeling;Monitor;Motivation;motivational enhancement therapy;multiphase optimization strategy;Outcome;participant retention;Patient Recruitments;Perception;Persons;Phase;Policies;Population;post intervention;pre-exposure prophylaxis;Prevalence;prevention service;Prevention strategy;programs;Protocols documentation;Provider;Randomized;Recommendation;recruit;resilience;Resource-limited setting;response;Risk;Risk Reduction;Risk Taking;satisfaction;sex;sexual identity;side effect;skills;social cognitive theory;social stigma;Stigmatization;substance use;System;Target Populations;Technology;Testing;Thailand;therapy design;therapy development;transgender women;Translating;Treatment Efficacy;United States National Institutes of Health;uptake;usability;Work;Youth

PROJECT_TITLE: Optimizing mobile interventions to overcome stigma and promote HIV prevention among Thai young transgender women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-K (02)]


NIH_SPENDING_CATS: Clinical Research;Obesity

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: The POWERS consortium protocol includes substantially more data collection, from more data streams, than was envisioned in our proposal. Dr. Jakicic is more involved with the intervention, interventionists, and subcommittees than originally envisioned. With one of the Clinical Centers including multiple institutions and numerous protocol amendments, the data management and administrative effort is more than originally envisioned and the costs for the single IRB are higher than anticipated. This results in the need for additional effort provided by investigators and other DCC personnel.

PI_NAMEs: BELLE, STEVEN H. (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: adjudication;Administrative Supplement;Amendment;Body Weight decreased;clinical center;college;cost;Data;Data Collection;Data Coordinating Center;data management;data streams;Funding;Human Resources;Information Systems;Institution;Institutional Review Boards;Intervention;intervention delivery;Maintenance;Monitor;New York;Pennsylvania;Physiology;Protocols documentation;Research Personnel;Site;Systems Development;Time;Travel;Universities;Weight;Work

PROJECT_TITLE: The Physiology of the Weight Reduced State Data Coordinating Center


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE In Latin America, HIV disproportionately impacts sexual and gender minorities. Recent data from Peru suggests that the prevalence of HIV is as high as 12% among men who have sex with men and 21% among transgender women. We will leverage an ongoing social-behavioral intervention trial enrolling adolescents and young adults living with HIV and strong ties with the LGBTQI+ community in Lima, Peru to explore (1) how sexual identity aligns with prior consensual sexual behavior; (2) perceptions of common terms used to describe sexual and gender identity and differences according to education and socioeconomic status; and (3) reasons that sexual and gender minorities may refuse, withdrawal, or have limited in engagement in study and/or intervention activities. These activities will be critical to tailoring HIV prevention messages and deriving terminology that is intuitive and aligned with the Peruvian population for patient-centered HIV care and research activities.

PI_NAMEs: FRANKE, MOLLY FORREST (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Adolescent;Adolescent and Young Adult;Adult;Affect;AIDS prevention;Behavior Therapy;Caring;Communities;Data;Demographic Survey;Education;Ensure;Family;Fright;Gender Identity;Goals;Health;Health Personnel;Healthcare;HIV;Homophobia;Human immunodeficiency virus test;Individual;Infection;Intervention;Intuition;Label;Latin America;Latin American;Medical;men who have sex with men;Monkeypox;patient oriented;patient population;Perception;Peru;Peruvian;Population;pre-exposure prophylaxis;Prevalence;Preventive;Reporting;Research;Research Activity;Risk;Sex Behavior;Sex Orientation;Sexual and Gender Minorities;sexual identity;social;sociodemographics;Socioeconomic Status;Standardization;Stigmatization;Surveys;Terminology;transgender women;transphobia;trial enrollment;Withdrawal;Youth

PROJECT_TITLE: Efficacy of a differentiated care intervention for adolescents transitioning to adult HIV care in Peru

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(53)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Climate-Related Exposures and Conditions;Dementia;Neurodegenerative;Neurosciences;Nutrition;Social Determinants of Health

PHR: PROJECT NARRATIVE  Long-term exposure to fine particulate matter (PM2.5) air pollution has been indicated in prior studies to be associated with Alzheimer’s disease onset and progression, but there are few studies that have assessed the association between PM2.5 exposure and Alzheimer’s disease mortality, and even fewer on variations in particle origin or characteristics’ effects on PM2.5 exposure associations with Alzheimer’s disease. Utilizing a robust study design with a well characterized human cohort of over 500,000 participants, this Workplace Diversity Supplement research will evaluate this PM2.5-Alzheimer’s disease associations with a focus on particle size, source, and composition exposure variations, and will also evaluate the potentially modifying effects of diet and health opportunity disparity. The information gained from this study will help direct environmentally focused policies, potentially leading to mitigative approaches for such neurodegenerative disorders.

PI_NAMEs: HAYES, RICHARD BERNARD;THURSTON, GEORGE DOUGLAS (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Air Pollution;Alzheimer's Disease;Alzheimer's disease risk;Antioxidants;Award;Carbon Black;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Censuses;Cessation of life;Characteristics;Charon;cohort;Cohort Studies;Communities;Consumption;Cox Proportional Hazards Models;Data;Diabetes Mellitus;Diet;dietary;Disease;Disease Progression;Disparity;Diverse Workforce;Doctor of Philosophy;Environment;Epidemiology;experience;Exposure to;fine particles;Food;Funding;Goals;Grant;hazard;Health;health application;Health Status;Human;human old age (65+);indexing;Individual;Investigation;Measures;Medical center;Mentors;Mentorship;Modification;mortality;mortality risk;National Institute of Environmental Health Sciences;neighborhood disadvantage;Neurodegenerative Disorders;Nutrient;Older Population;Onset of illness;parent grant;Parents;Participant;particle;particle exposure;Particle Size;Particulate Matter;Policies;Population;Research;Research Design;residence;respiratory;Risk;Source;Subgroup;Training;United States;United States National Institutes of Health;Variant

PROJECT_TITLE: Variations in long-term fine particulate matter air pollution associations with mortality by particle size, source, and composition - Diversity Supplement


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SPRINGFIELD

ORG_NAME: BAYSTATE MEDICAL CENTER, INC.

PHR: PROJECT NARRATIVE Women who have experienced hypertensive disorders in pregnancy are at significantly elevated risk of future cardiovascular disease, but postpartum healthcare visits may not occur and/or may not adequately address this heightened risk. The proposed supplement will enhance our parent grant to examine how clinician factors contribute to cardiovascular risk management in primary care in the postpartum year for women from underserved populations. Findings will contribute to an improved understanding of system factors associated cardiovascular risk management in postpartum primary care for women at high risk, and help to identify interventions, healthcare quality metrics, and policy levers to improve clinical practice particularly for underserved women.

PI_NAMEs: ATTANASIO, LAURA B;GEISSLER, KIMBERLEY LYNN H (contact)

PROGRAM_OFFICER_NAME: POOL, LINDSAY REGINA

PROJECT_TERMS: Address;Administrative Supplement;adverse outcome;Age;Birth;black women;Blood Pressure;Body mass index;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;care systems;career;Caring;Cause of Death;Characteristics;child bearing;Chronic;Cigarette;Clinical;clinical care;clinical practice;Data;Data Sources;Databases;design;disadvantaged women;Disease Outcome;Disparity;Eclampsia;Enhancers;Ethnic Origin;Ethnic Population;experience;Face;Family history of;Funding;Future;health care quality;Health Care Visit;health inequalities;Healthcare;Heart failure;high body mass index;high risk;High Risk Woman;Hyperlipidemia;Hypertension;hypertension treatment;improved;Individual;individual patient;Institution;Insurance;Insurance Coverage;interest;Intervention;Low income;marginalization;Massachusetts;maternal morbidity;Maternal Mortality;Measurement;Medicaid;Metabolic syndrome;Methods;Minority;Minority Groups;mortality;Myocardial Ischemia;National Heart, Lung, and Blood Institute;parent grant;Patients;Policies;Population;postpartum care;postpartum health;Postpartum Period;Postpartum Women;Pre-Eclampsia;Pregnancy;pregnancy hypertension;Premature Mortality;Primary Care;primary care visit;provider factors;Race;racial disparity;racial minority population;Recommendation;Recording of previous events;Records;reproductive;Research;Research Personnel;response;Risk;Risk Assessment;Risk Factors;Risk Management;sex;Smoking;Stroke;System;Underserved Population;United States;Visit;White Women;Woman;women of color;Women's Health;Women's mortality;women's outcomes

PROJECT_TITLE: System factors influencing the postpartum transition to primary care for cardiovascular disease risk management among women with hypertensive disorders in pregnancy


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Opioid Misuse and Addiction;Opioids;Primary Health Care;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed work is relevant to public health given the high rates of opioid use disorder and resultant morbidity and mortality among individuals just released from jails. The project is relevant to NIDA's mission- driven strategic goals to improve opioid use disorder treatment among this high-risk population and to optimize clinical and implementation research to improve health and reduce disease. By building strategic partnerships with individuals with a history of incarceration and community and correctional policymakers, we will improve dissemination and implementation of evidence-based research findings into policy and practice.

PI_NAMEs: WANG, EMILY AI-HUA (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: addiction;Address;Administrative Supplement;Advocate;Affect;career;Caring;Clinic;Clinical Research;Communities;Community Health Aides;comorbidity;compare effectiveness;Criminal Justice;Disease;Dissemination and Implementation;effectiveness/implementation trial;evidence base;Faculty;follow-up;Food Access;food insecurity;Funding;General Population;Goals;Health;Health system;Healthcare;high risk;high risk population;Housing;housing instability;Hybrids;implementation research;Imprisonment;improved;Individual;internalized stigma;Intervention;Jail;Justice;Knowledge;Measures;Mediating;Mental Health;Mission;Morbidity - disease rate;mortality;National Institute of Drug Abuse;novel;Opioid;opioid epidemic;opioid use disorder;Outcome;Overdose;Participant;Patients;Persons;Pharmaceutical Preparations;physical conditioning;Policies;Policy Maker;preference;preservation;Primary Care;primary care team;programs;Public Health;Randomized;Recording of previous events;recruit;Research;Risk;Site;Sleep;social determinants;Social support;System;Treatment outcome;Trust;United States;United States National Institutes of Health;Work

PROJECT_TITLE: TCN PATHS Supplemental funding


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Sexual harassment is endemic for physicians in medicine, negatively impacting victims and bystanders, and resulting in poor mental health, burnout, isolation, and attrition in the physician workforce. This study will help us understand why and how some institutions have better rates of sexual harassment and physician well- being. By identifying strategies used by top-performing institutions, we will be able to share these “best practices and policies” to improve physician well-being and mitigate the impact of sexual harassment.

PI_NAMEs: OLIVERIO, ANDREA L;VIGLIANTI, ELIZABETH MARIE (contact)

PROGRAM_OFFICER_NAME: IGNACZAK, AARTEE

PROJECT_TITLE: ARISING: AddRessing Institutional Sexual harassment to Improve physiciaN well-beinG

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Mental Health;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: Pasadena

ORG_NAME: HUNTINGTON MEDICAL RESEARCH INSTITUTES

PHR: PROJECT NARRATIVE Chronic stress can result in negative health effects, including inflammation, cardiovascular disease, and Alzheimer's disease and related dementias (ADRD); American Indian (AI) populations have endured excess stresses and traumas, but have also shown remarkable psychosocial resilience, which may be related to robust social support, community environment, cultural identity. It is unclear which of these psychosocial features may be most predictive of psychosocial resilience in AI adults, or whether any is protective against neurodegeneration and ADRD. A search on NIH Reporter uncovered many projects focused on cognitive reserve—sometimes also called resilience—but none on psychosocial resilience or its related features as protective health characteristics in adult AIs. This project seeks to fill this knowledge gap with novel data collection and analysis on trait-based psychosocial resilience, related features, cognitive function, and ADRD in 3000 adult AIs as part of the ongoing Strong Heart Study.

PI_NAMEs: SUCHY-DICEY, ASTRID M (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Address;Adult;Age;aging brain;Alzheimer's disease related dementia;Alzheimer's disease risk;American Indian community;American Indian Population;American Indians;Anger;Behavioral;bullying;Cardiovascular Diseases;Characteristics;Chronic;Chronic stress;Clinic;Clinical;clinical examination;Cognition;cognitive function;cognitive reserve;cohort;Cohort Studies;Communities;Consent;Contracts;Data;Data Analyses;Data Collection;Dementia;Development;Diné Nation;disability;Discrimination;Disparity;Economic Conditions;Eligibility Determination;eligible participant;Emotional;Emotions;Environment;Epidemiology;epidemiology study;Event;experience;Failure;Family;Female;Funding;Genetic;harassment;Health;healthy aging;Heart;heterogenous data;Hostility;Impaired cognition;improved;Individual;Inflammation;instrument;intergenerational;Knowledge;Life;Life Stress;Link;Longitudinal cohort;Machine Learning;machine learning classification;male;Mediating;Mental Depression;Methods;Modeling;mortality;National Heart, Lung, and Blood Institute;Navajo;Nerve Degeneration;Neuropsychology;novel;optimism;Outcome;Participant;Patient-Centered Care;Persons;Philosophy;Poverty;practical application;promote resilience;Protocols documentation;psychosocial;Psychosocial Factor;Public Health;public health intervention;Quality of life;Recording of previous events;recruit;Reporter;Research;resilience;Resources;Risk;screening;sex;Social Network;Social support;sociodemographics;Socioeconomic Factors;socioeconomics;Spirituality;Stress;theories;Time;trait;Trauma;tribal community;Tribes;Underserved Population;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Resilience, cultural alignment, and social support in brain aging: the Strong Heart Study


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Our collaboration of diverse researchers, clinicians, and community members seeks to better understand the health research needs and priorities of intersex and variations of sex characteristics (I/VSC) communities: Existing models of health information and data collection completely omit I/VSC populations, inaccurately assess I/VSC status, or fragment the population by diagnoses. There is a dearth of literature that explores the social behavioral aspects of the lives of I/VSC people (e.g., alcohol use, depression), and little is known about the disparities of these factors among I/VSC individuals who are also racial/ethnic, sexual, or gender minorities. This supplement study can be a model of community building and healing as we leverage the tenets of participatory action research (PAR), grounding our work in community-based needs and emphasizing collective action, leading to community transformation and social change.

PI_NAMEs: BEACH, LAUREN BRITTANY;PHILLIPS, GREGORY L. (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Adoption;Affect;Age;Alcohol consumption;alcohol measurement;alcohol misuse;Behavioral;binge drinking;Caring;Clinical;Collaborations;Communities;community based participatory research;community building;Community Developments;community engagement;community organizations;community partners;Computer software;Computerized Medical Record;Data Collection;Dedications;Deformity;Development;Diagnosis;Discrimination;Disparity;drinking behavior;Epidemiology;Equity;ethnic minority;Ethnic Origin;Exclusion;experience;Face;Feedback;Female;Foundations;Future;Gender;Gender Identity;gender minority;gender minority health;gender minority health research;Genitalia;Geography;Grant;healing;Health;health care service utilization;health determinants;health disparity;health equity;health equity promotion;Health Professional;Health Promotion;Healthcare;Hormonal;Hormones;Human Rights;Human Rights Abuses;improved;Individual;informant;insight;interdisciplinary collaboration;interest;intersectionality;Intersex;Intervention;Interview;Investments;Language;Lead;Learning;Legal;lens;Life Cycle Stages;Link;Literature;male;Measurement;Measures;Medical;Medical Students;member;Mental Depression;Mental Health;Methods;Minority;minority stress;Modeling;Navigation System;Operative Surgical Procedures;Outcome;parent grant;parent project;Participant;Pathway interactions;Patient Self-Report;Perception;Personal Satisfaction;Persons;physical conditioning;Physicians;Policies;Population;Population Surveillance;Positioning Attribute;preference;Process;programs;Public Health;public health research;Qualitative Methods;Race;racial minority;recruit;Reporting;Research;research and development;Research Design;research in practice;Research Methodology;Research Personnel;Research Priority;Risk;scale up;Secrecy;sex;Sex Characteristics;Sex Chromosomes;sex development disorder;sex disparity;sex linked trait;Sex Orientation;sex variable;Sexual and Gender Minorities;Sexual Development;sexual minority;Shame;Shapes;social;Social Change;social health determinants;Specific qualifier value;Structure;Surveys;System;theories;tool;Trust;United Nations;Universities;Variant;Work

PROJECT_TITLE: Improving Measurement of Alcohol Use and Other Disparities by Sex, Sexual Orientation, and Gender Identity through Community Engagement

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PI_NAMEs: MAHMUD, AYESHA SANCHITA (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TITLE: Novel data and approaches for dynamic modeling of human behavior and infectious disease ecology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-F (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: Malden

ORG_NAME: BRAIN THRIVE TECHNOLOGY LLC

PHR: Project Narrative The aim of this application is to develop a computer-based multimodal mind and body approach (CMMBA) for mild cognitive impairment (MCI). This product will provide a new, cost-effective and easily accessible treatment option for MCI and potentially other age-related dementia.

PI_NAMEs: KONG, JIAN  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Acupressure;age related;Alzheimer's Disease;Alzheimer's disease therapy;Baduanjin;Characteristics;clinical diagnosis;cognitive function;Computers;cost effective;Dementia;Development;Disease;effective therapy;Exercise;Feasibility Studies;Goals;Home;Impaired cognition;improved;Individual;innovation;Innovation Corps;Intervention;Methods;mild cognitive impairment;mind/body;Movement;multimodality;Neurologic;normal aging;older adult;Patients;Persons;Pharmacological Treatment;Phase;Posture;Prevention;Preventive therapy;Probability;prototype;Relaxation Techniques;response;Small Business Technology Transfer Research;strength training;Tendon structure

PROJECT_TITLE: I-Corps - Developing of a computer-based multimodal mind and body approach for mild cognitive decline


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Rehabilitation;Substance Misuse

ORG_CITY: PALO ALTO

ORG_NAME: AMYGDALA NEUROSCIENCES, INC.

PHR: PROJECT NARRATIVE Preclinical and available clinical data highlight the potential of ANS-858, a selective, reversible ALDH2 inhibitor, as a promising drug to treat patients diagnosed with alcohol use disorder (AUD). The I-Corps grant shall provide us the opportunity to gain further insight as to the potential for ANS-858.

PI_NAMEs: BLACKBURN, BRENT KEITH (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: acamprosate;Adopted;Adult;alcohol abuse therapy;Alcohol consumption;alcohol use disorder;American;attributable mortality;Biological Availability;Centers for Disease Control and Prevention (U.S.);Clinical Data;Cognitive Therapy;commercialization;Counseling;Development;Diagnosis;Disulfiram;drinking;economic cost;Eligibility Determination;FDA approved;Grant;Health Services Accessibility;Improve Access;inhibitor;Innovation Corps;insight;Investigational Drugs;Knowledge;mobile application;Modeling;Modernization;Naltrexone;Oral;Outcome;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Population;pre-clinical;Privatization;programs;psychosocial;Recovery;Risk;Role;Societies;Therapeutic;Therapeutic Agents

PROJECT_TITLE: Investigational New Drug (IND)-enabling and Early-Stage Development of Selective, Reversible, Orally Bioavailable ALDH2 inhibitor ANS-00858 to Treat Alcohol Use Disorder.


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research;Pediatric;Precision Medicine;Prevention

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: The project aims to transform the management of chronic musculoskeletal pain in youth by harnessing wearable technology and advanced analytics. It is predicated on developing a real-time digital biosignature through machine learning algorithms, which will provide an objective, comprehensive assessment of the pain experience beyond self-reporting. This endeavor not only promises to enhance patient outcomes through personalized interventions but also stands to significantly reduce the economic and emotional burden of chronic pain by enabling timely and effective treatment strategies.

PI_NAMEs: AGHAEEPOUR, NIMA ;SIMONS, LAURA E (contact)

PROGRAM_OFFICER_NAME: ARUDCHANDRAN, RAMACHANDRAN NMN

PROJECT_TERMS: Adolescent;Adoption;Adult;advanced analytics;Advocacy;Affect;Age;Artificial Intelligence;Biological;biosignature;Caregivers;chronic musculoskeletal pain;chronic pain;Clinical;Clinical Research;Clinical Trials;clinically significant;Cognition;Collaborations;commercialization;Complex;Computer software;Consultations;Coupled;dashboard;Data;Data Collection;Deterioration;Development;Diagnosis;digital;digital data;digital health;digital monitoring;digital technology;Economic Burden;Economics;effective therapy;Effectiveness;Emotional;emotional functioning;empowerment;Enrollment;Ensure;Evolution;experience;fall risk;Family;Fatigue;Feedback;Flare;Future;Gait;Glucose;Health;health disparity;Health Personnel;Health Technology;Heart;Human;Impairment;improved;Individual;insight;Intervention;Interview;learning algorithm;Life;Lived experience;Machine Learning;machine learning algorithm;Measures;Methods;Monitor;Moods;Musculoskeletal Pain;open source;Operative Surgical Procedures;Outcome;outreach;Pain;Pain intensity;Pain interference;Pain management;Pain Measurement;Panic Attack;Patient Selection;Patient Self-Report;patient stratification;Patient-Focused Outcomes;Patients;Performance;personalized approach;personalized intervention;Phase;Physical activity;Physical Function;Physiologic Monitoring;Physiological;point of care;Positioning Attribute;Premature Birth;Prevention;Quality of life;Questionnaires;Reading;Recovery;recruit;Research Project Grants;respiratory;response;Risk;scalable algorithms;Schools;Secure;skills;Sleep;social stress;Specificity;Standardization;Stress;System;therapeutic development;Time;treatment optimization;Treatment outcome;treatment response;treatment strategy;Uncertainty;Update;usability;Validation;wearable device;Youth

PROJECT_TITLE: Targeted Realtime Assessment of Chronic Pain (TRAC-Pain) in Youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-R (22)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Immunotherapy;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: YORKTOWN HEIGHTS

ORG_NAME: TINKESO THERAPEUTICS INC

PHR: PROJECT NARRATIVE  This research could be translated into development of allogeneic, off-the-shelf, non-edited, CD7 CAR-modified iNKT cell therapy for the treatment of patients with relapsed and refractory acute lymphoblastic leukemia and acute myeloid leukemia.

PI_NAMEs: ZHOU, XIANZHENG  (contact)

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Acute T Cell Leukemia;Agonist;Allogenic;Animals;anti-cancer;Antigen Presentation;Antigens;Apoptotic;Autoimmune Diseases;B-Cell Neoplasm;BCL2 gene;BCL2L1 gene;Biological Assay;bioluminescence imaging;Biotin;Biotinylation;Blood Cells;cancer therapy;CAR T cell therapy;CD19 gene;CD28 gene;CD3 Antigens;CD7 gene;Cell Physiology;Cell Survival;Cells;checkpoint receptors;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cost;Crowding;CTLA4 gene;Custom;cytokine;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Development;Doctor of Philosophy;Donor Selection;Enzyme-Linked Immunosorbent Assay;experimental study;Fc Receptor;Flow Cytometry;Frequencies;Genes;genome editing;Glycolipids;Goals;Grant;Growth;Hematologic Neoplasms;Human;IL7 gene;Industry;Infusion procedures;innovation;Interferons;Interleukin-15;interleukin-21;Investments;Lentivirus;Lentivirus Vector;leukemia;Lymphoblastic Lymphoma;Malignant Neoplasms;manufacture;Mediating;Medical;member;Microspheres;Nature;neoplastic cell;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Phase;Phenotype;Phosphorylation;Physiologic pulse;Population;Production;programmed cell death protein 1;programs;Proliferating;Reagent;receptor expression;Refractory;Relapse;Research;response;Role;Safety;screening;Signal Transduction;Small Business Innovation Research Grant;Stat5 protein;symposium;T cell therapy;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Therapeutic;therapy development;Time;Transact;Transfection;Translating;tumor;vector;Vendor;web site;Xenograft Model

PROJECT_TITLE: Chimeric antigen receptor-modified iNKT cell therapy for CD7+ malignancies


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Nutrition;Rare Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Turner syndrome, a condition exclusive to females, occurs when one of the X chromosomes (sex chromosomes) is absent or partially missing, affecting multiple organs. The aim of this administrative supplemental application is to fill a significant gap in tuner syndrome research by addressing how the missing sex chromosome impacts liver health in this unique female population. Knowledge gained from our studies may lay a critical foundation for future translational studies contributing to the well-being of Turner Syndrome patients.

PI_NAMEs: WANG, SHUXIA  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: 3-Dimensional;acetaminophen overdose;Address;Adenoviruses;Administrative Supplement;Affect;Alanine Transaminase;Animals;Area;Aspartate Transaminase;ATAC-seq;Biliary;Birth;Body System;cardiogenesis;Categories;Cell Culture Techniques;Cells;Chromosome abnormality;Cirrhosis;Code;comparison control;demethylation;Development;Diet;differential expression;Elements;Enzymes;Estrogens;Exhibits;Face;Fatty Acids;fatty liver disease;Female;Foundations;Future;gender minority group;Genes;genotypic sex;Health;Healthcare;hearing impairment;Heart Diseases;Hepatocyte;Hepatotoxicity;Histology;Histones;Hormone replacement therapy;Hyperinsulinism;Hyperplasia;In Vitro;in vivo;Individual;Infertility;kidney malformation;Knowledge;Laboratories;Link;lipid metabolism;Liver;Liver Cirrhosis;Liver diseases;Liver Dysfunction;liver injury;medical complication;Metabolic;Modeling;Molecular;mouse model;Mus;non-alcoholic fatty liver disease;Obesity;Organ;Organoids;Outcome;Patients;Personal Satisfaction;Phenotype;Play;Population;regenerative;Reporting;Research;Risk;Role;Sex Chromosomes;sexual minority group;small hairpin RNA;Somatotropin;Steatohepatitis;Supplementation;Symptoms;Syndrome;Techniques;Testing;tool;transcriptome sequencing;translational study;Triglycerides;Turner's Syndrome;uptake;vector;Woman;X Chromosome

PROJECT_TITLE: Administrative Supplements for Research on Sexual and Gender Minority (SGM) Populations

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Drug Abuse (NIDA only);Health Services;Prevention;Primary Health Care;Substance Misuse

ORG_CITY: Provo

ORG_NAME: AXCEND, LLC

ORG_STATE: UT

PHR: Project Narrative Monitoring of illicit drug use is a critical component of care in drug treatment facilities and pain clinics, as well as in other situations where patients may be at risk of substance use disorders. This project focuses on improved analytical methodologies to perform this type of testing in point-of-care settings by using a compact capillary liquid chromatograph. The new approaches developed here will provide improvements to current point-of-care screening assays by providing higher specificity, rapid turn-around, and the capability to look at multiple drug classes with a single instrument.

PI_NAMEs: LEE, MILTON L. (contact)

PROGRAM_OFFICER_NAME: NGUYEN, TAM L

PROJECT_TERMS: absorption;Academia;Algorithmic Software;Algorithms;aqueous;Area;Barbiturates;Benchmarking;Benzodiazepines;Biological Assay;Blood capillaries;Body Fluids;capillary liquid chromatography;Caring;Cells;Characteristics;Chemicals;Chromatography;Collaborations;Column Chromatography;commercialization;Complex;computerized data processing;cost;Coupled;Coupling;data handling;data library;design;Detection;detection limit;detection sensitivity;detector;Development;Devices;Disease;Drug Monitoring;drug of abuse;Drug Rehabilitation Centers;Drug Screening;Drug Targeting;drug testing;Ensure;Environment;Equipment;Gas Chromatography;Gold;Guidelines;Healthcare;illicit drug use;Illicit Drugs;Immunoassay;improved;Individual;innovation;instrument;interest;Length;Liquid Chromatography;liquid chromatography mass spectrometry;Liquid substance;Mass Fragmentography;Mass Spectrum Analysis;Methodology;Methods;Monitor;novel;novel strategies;operation;Pain Clinics;Paper;Patient Care;Patients;Performance;Pharmaceutical Preparations;Pharmacotherapy;Phase;point of care;point of care testing;Preparation;Professional Practice;Protocols documentation;Recommendation;Research;Resolution;Risk;routine screening;Sampling;Scientist;screening;Sensitivity and Specificity;Services;Small Business Innovation Research Grant;Solid;Solvents;Specificity;Substance Abuse Detection;Substance abuse problem;substance abuse treatment;Substance Use Disorder;System;tandem mass spectrometry;Technical Expertise;Techniques;Technology;Test Result;Testing;Therapeutic;United States Substance Abuse and Mental Health Services Administration;Urine

PROJECT_TITLE: Compact Liquid Chromatography for Routine Screening in Drug Treatment Centers


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project narrative Alzheimer’s disease (AD) has no treatment and drug trials are increasingly focused on earlier AD stages, so we need to better understand and detect early AD pathogenesis. This project focuses on Apolipoprotein E (APOE), the strongest genetic risk factor for AD, using cutting-edge technologies to analyze the entire molecule including its glycosylation (sugars attached to the protein), and how this glycosylation affects the still unexplained role of APOE in the disease process at these early stages. We will use stem cells produced from patient skin samples to understand the functional impact of changes to APOE glycosylation seen in aging and AD and determine their effects on critical characteristics of AD pathogenesis.

PI_NAMEs: FLOWERS, SARAH ANN (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta accumulation;Address;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Binding;Biological Assay;Brain;Cell Line;cell type;Cells;Characteristics;Charge;Coculture Techniques;Data;Disease;Early Diagnosis;Environment;Enzymes;Flowers;genetic risk factor;Genotype;Glycobiology;Glycoproteins;glycoproteomics;glycosylation;glycosyltransferase;Health;Hepatocyte;Human;improved;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Late Onset Alzheimer Disease;Lipid Binding;Lipids;Lipoprotein Binding;Lipoproteins;Location;Measures;Methods;Microelectrodes;Modeling;Modification;Monosaccharides;Mutation;Nervous System;Neurons;novel;Pathogenesis;Pathogenicity;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Plasma;Polysaccharides;Process;promoter;Property;Protein Isoforms;Proteins;receptor;receptor binding;response;Risk;Role;Sampling;sialylation;Sialyltransferases;Site;Skin;Source;stem cells;sugar;Techniques;Technology;Testing;Tissues;tool;Transferase;Work

PROJECT_TITLE: Apolipoprotein E glycosylation and its role in Alzheimer's disease pathogenesis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: Although declining health of blood vessels in the brain is now thought to contribute to many cases of Alzheimer’s disease and other dementias, there are no treatments that target blood vessel health. Here, we will use gene and protein profiling from brain samples of human AD patients and mouse models to identify putative therapeutic targets. Data will be integrated and analyzed to prioritize candidate genes and proteins that will be tested for their ability to reduce damage to blood vessels in the brain using mouse models.

PI_NAMEs: HOWELL, GARETH R (contact);SEYFRIED, NICHOLAS THOMAS

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acceleration;Affect;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid deposition;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Automobile Driving;Autopsy;Bayesian Modeling;Biological Assay;Biological Markers;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;Brain;brain tissue;Candidate Disease Gene;cell type;Cells;Cerebral Amyloid Angiopathy;cerebral artery;cerebrovascular;Cerebrovascular Disorders;cerebrovascular health;Cerebrovascular system;Cerebrum;Clinical;Clinical Data;Clinical Trials;Cognition;Cognitive;cognitive ability;Complement;Data;Data Set;Dementia;Deposition;Development;Disease;Effectiveness;end stage disease;endophenotype;Endothelial Cells;Evaluation;Face;Follow-Up Studies;Functional disorder;Gene Expression Profile;Genes;genetic risk factor;Genotype;Goals;Health;Human;human data;Impaired cognition;improved;knockout gene;Knowledge Portal;Laboratories;Late Onset Alzheimer Disease;Libraries;Link;Liquid substance;Magnetic Resonance Imaging;Maps;Mediating;Mediator;Medicine;Memory;model organism;Molecular;molecular scale;Molecular Target;mouse model;Multiomic Data;multiple omics;Mus;Nerve Degeneration;Neurofibrillary Tangles;neuropathology;new therapeutic target;novel;novel therapeutics;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Pericytes;Persons;Phenotype;Plasma;Prevalence;prevent;protein profiling;Proteins;Proteome;Proteomics;Publishing;religious order study;repository;Resolution;Resources;response;Sampling;Senile Plaques;single nucleus RNA-sequencing;Smooth Muscle Myocytes;tau aggregation;tau Proteins;Testing;The Jackson Laboratory;therapeutic candidate;therapeutic target;Tissue Model;Tissues;transcriptomics;trend;Universities;Variant;vascular cognitive impairment and dementia;Vascular Smooth Muscle;Work

PROJECT_TITLE: VCID CWOW: Identifying Novel Targets to Treat Cerebral Amyloid Angiopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-M (21)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Down Syndrome (DS) is an Alzheimer’s disease related disorder (ADRD) that involves traditional AD neuropathology and cognitive impairment at an accelerated rate. We propose to use well- characterized, biobanked plasma samples from the Vitamin E in DS trial to characterize AD biomarkers and develop a precision medicine approach for use of anti-inflammatories in DS trials. In this proposal we will utilize our expertise in high throughput proteomics and analytics to better characterize our sample set and expand the database for this trial.

PI_NAMEs: RAFII, MICHAEL S;RISSMAN, ROBERT  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Acceleration;Adult;Age;aging population;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloid beta-Protein;Animal Model;Anti-Inflammatory Agents;Antiinflammatory Effect;Antioxidants;Astrocytes;Attention;Basic Science;biobank;Biological;Biological Assay;Biological Markers;biomarker validation;blood-based biomarker;Classification;Clinical;Clinical Trials;cognitive performance;Cohort Studies;Consultations;Data;Databases;Dementia;design;Development;Disease;Disease Progression;Down's Syndrome;effective therapy;endophenotype;Enrollment;Epidemiology;Exhibits;exosome;Future;Genetic;Human;Immune signaling;Impaired cognition;Individual;Inflammation;Inflammatory;Infrastructure;Intellectual functioning disability;Intervention;Letters;Literature;Longitudinal Studies;Methods;Modeling;Nerve Degeneration;neuroinflammation;Neurons;neuropathology;novel therapeutics;Outcome;Pathologic;patient subsets;Patients;Penetration;Phase III Clinical Trials;Plasma;Population;pre-clinical;precision medicine;predictive marker;Predisposition;prevent;Prevention;Procedures;Property;Proteomics;Sampling;Subgroup;Symptoms;tau Proteins;Techniques;Testing;Therapeutic;Therapeutic Trials;therapy outcome;Time;treatment response;virtual;Vitamin E;Work

PROJECT_TITLE: Precision Medicine for Inflammatory Treatment for Alzheimer's Disease in Down Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-W(55)]