NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Precision Medicine

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Electronic health record (EHR) data holds immense potential for the study and care of Alzheimer’s disease and related dementias (ADRDs) through the development of clinical tools and the study of disease heterogeneity and current care practices. However, selection bias, measurement error, and missing data can all lead to bias in EHR-based studies and tools, especially among patients who face barriers to healthcare access. The proposed training and research plan would lead to EHR analysis methods for ADRDs that address these sources of bias and would provide Dr. Adams with the unique combination of advance computational skills and understanding of ADRD care necessary to make significant contributions to the ADRD precision medicine in the future.

PI_NAMEs: ADAMS, ROY  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;barrier to care;Big Data;Biological;Biology;Calibration;care fragmentation;career;Caring;Clinical;clinical development;Code;cohort;Complex;Computer software;Computing Methodologies;computing resources;cost;Data;Databases;Dementia;dementia care;detection method;Development;Diagnosis;diagnosis standard;Disease;disease heterogeneity;Electronic Health Record;Environment;Equity;Error Sources;experience;Exposure to;Family;Foundations;Funding;Future;geriatric neuropsychiatry;Goals;health care availability;health data;Heterogeneity;high dimensionality;high risk;improved;interest;Journals;K-Series Research Career Programs;large scale data;Lead;Learning;Longitudinal Studies;Machine Learning;machine learning method;Measurement;Measures;Memory;Mentors;Methodology;Methods;model building;Modeling;open source;Outcome;Pathology;Patient Care;patient population;patient subsets;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Phenotype;precision medicine;Precision Medicine Initiative;Productivity;Proxy;Psychiatric epidemiology;Public Health;repository;Research;Research Personnel;Resources;Risk;Risk Factors;Sample Size;Selection Bias;Severities;skills;Source;supervised learning;Time;tool;Training;training data;treatment center;United States National Institutes of Health;Validity and Reliability;Work

PROJECT_TITLE: Machine learning-based methods for phenotyping dementia patients from electronic health record data

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Regenerative Medicine

ORG_CITY: CHESTNUT HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: PROJECT NARRATIVE To develop (or regenerate) a complex organ such as a limb, tissues must be able to interpret (or remember) their relative positions, then deploy this positional information to inform appropriate size, pattern and shape. This research program will use the regenerating zebraﬁsh ﬁn to reveal pathways that underlie the morphogenesis of form, focusing not only on the growth and size of the organ, but also the skeletal patterning along the proximodistal axis and the overall shape of the appendage. This research program is expected to inform the logic of fundamental developmental mechanisms, which can open new possibilities in treating congenital limb disorders and help pave the way towards regenerative therapies.

PI_NAMEs: MCMENAMIN, SARAH KELLY (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TITLE: Illuminating the mechanisms that generate pattern and shape during growth and regeneration of the zebrafish fin

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: HANOVER

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE/RELEVANCE We will continue our goal of improving the resources available for future cancer research by providing innovative interdisciplinary training for postdoctoral fellows. This program is designed to provide early career researchers with opportunities to integrate specialized research knowledge and methodologies within the fields of bioinformatics, biostatistics and epidemiology. Trainees will be positioned to expedite the translation of cancer science into clinical and public health practice as leaders on multidisciplinary research teams.

PI_NAMEs: KARAGAS, MARGARET RITA (contact);TOSTESON, TOR D;WHITFIELD, MICHAEL L

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Malignant Neoplasms;Population Sciences;Training Programs

PROJECT_TITLE: Training Program for Quantitative Population Sciences in Cancer


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;HIV/AIDS;Liver Disease;Patient Safety;Precision Medicine;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: JUSTICE, AMY CAROLINE (contact)

PROJECT_TERMS: Accounting;Aging;Alcohol consumption;alcohol effect;alcohol exposure;alcohol measurement;alcohol misuse;alcohol research;alcohol response;alcohol risk;alcohol use disorder;Alcoholic Liver Diseases;Alcohols;Anti-Retroviral Agents;behavior change;Behavioral;Collaborations;Communication;Complex;Consumption;Data;Data Analytics;Delirium;Drug Prescriptions;drug repurposing;Effectiveness;Evaluation;falls;frailty;Genetic;Health;HIV;Hospitalization;improved;indexing;Individual;interest;Intervention;Liver Cirrhosis;Liver diseases;liver metabolism;Measures;Modeling;mortality;Motivation;motivational enhancement therapy;Neurocognitive;Outcome;Patient Self-Report;Patient-Focused Outcomes;Patients;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacogenomics;Phenotype;Physiological;Pilot Projects;Pneumonia;polygenic risk score;Polypharmacy;Readiness;Reporting;Resources;Risk;Risk Assessment;Role;Safety;Series;skills;Testing;theories;Toxic effect;Work

PROJECT_TITLE: Personalizing Risk from Alcohol among HIV+/-: Genetics, Medication Toxicity and PEth


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The enormous societal burden of Alzheimer's disease (AD) and lack of effective means of prevention and treatment emphasize the importance of better understanding AD pathogenesis to find new targets of intervention. This project will perform innovative research to discover AD-specific sialoglycoproteome changes and identify novel biomarkers and targets for improving AD diagnosis and treatment.

PI_NAMEs: LI, LIAN  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Address;Affect;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease diagnostic;Alzheimer's Disease Pathway;Alzheimer's disease risk;Alzheimer’s disease biomarker;Animal Model;Area;Autopsy;Binding;Biological;Biological Markers;Biology;biomarker development;biomarker discovery;Blood;Brain;brain dysfunction;brain tissue;Carbon;case control;Cell surface;Cellular biology;Cerebrospinal Fluid;Charge;Clinical;Couples;Data;Dementia;Development;diagnostic development;Disease;disease prognosis;Disease Progression;DNA Sequence Alteration;Drug Targeting;Early Diagnosis;Early Intervention;effective therapy;Enzymes;extracellular;follow-up;Functional disorder;genome wide association study;Glycoproteins;glycoproteomics;Health;Homeostasis;Human;human disease;Immunoglobulins;improved;in vivo;innovation;insight;Intervention;Knowledge;Lectin;Link;Masks;Mass Spectrum Analysis;Mediating;Metabolism;mild cognitive impairment;Molecular;molecular recognition;Molecular Target;Monitor;Monosaccharides;Mutation;Neuraminic Acids;Neuraminidase;Neurodegenerative Disorders;Neurologic;neuropathology;novel;novel marker;NRCAM gene;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Post-Translational Protein Processing;Prevention;Process;Protein Conformation;protein folding;Proteins;Research;Resolution;Risk Factors;Role;Sampling;Serum;sialic acid binding Ig-like lectin;Sialic Acids;Sialoglycoproteins;sialylation;Sialyltransferases;Signal Transduction;Site;Source;Specimen;Study models;System;Systems Biology;targeted treatment;Testing;therapeutic development;trafficking;Translational Research;Validation

PROJECT_TITLE: Sialoglycoproteomic network and target discovery for Alzheimer's disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: DAVIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE The Study of Healthy Aging in African Americans (STAR) is a Black/African American cohort of 764 middle-aged and elderly individuals ages examining lifecourse risk factors on cognitive decline and vascular brain injury. In STAR Cycle 2 study outcomes will include incidence of Alzheimer's disease and dementia, blood-based and imaging biomarkers of neurodegeneration, and neuropathology. The proposed continuation of STAR will help redress disparities in cognitive ageing, and provide much needed public health information on lifecourse risk and resiliency factors for Alzheimer's disease in a population at highest risk.

PI_NAMEs: GILSANZ, PAOLA ;WHITMER, RACHEL A (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Address;Adolescence;Adult;African;African American;African American population;African American student;Age;age related;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Amyloid;Amyloid beta-Protein;Atrophic;Back;Behavioral;Biological Markers;Birth;Black Populations;Black race;Blood;Blood Vessels;blood-based biomarker;Brain;brain health;brain magnetic resonance imaging;California;cardiovascular risk factor;Caring;Cerebrovascular Disorders;Cerebrovascular Trauma;Childhood;Clinical;Clinical Data;Cognition;Cognitive aging;cognitive function;cognitive performance;cohort;Cohort Studies;Collection;college;Communities;Community Health;comorbidity;Consent;Data;Dementia;depressive symptoms;Desegregation;differences in access;Discrimination;Disparity;Education;Elderly;Enrollment;experience;Exposure to;Family member;Female;Glial Fibrillary Acidic Protein;Goals;Health;health disparity;healthy aging;high risk;high school;Hyperlipidemia;Hypertension;Image;imaging biomarker;Impaired cognition;improved;Incidence;Individual;Infrastructure;Institutional Racism;interest;Investigation;late life;Life;Life Cycle Stages;Life Experience;Life Style;Light;Longitudinal cohort study;Magnetic Resonance Imaging;Measures;Medical;Medical Records;member;middle age;Mothers;Nerve Degeneration;neurofilament;neuroimaging marker;neuropathology;Neuropsychology;Not Hispanic or Latino;Obesity;Occupations;older adult;Outcome Study;Participant;Personal Satisfaction;Population;Positioning Attribute;Positron-Emission Tomography;programs;prospective;protective factors;Psychosocial Factor;Public Health;recruit;Reporting;Research;resilience;resilience factor;Risk Factors;Risk Reduction;Schools;segregation;sex;Socioeconomic Status;Stress;Stroke Belt;Surveys;tau Proteins;United States;vascular injury;vascular risk factor;Visit;Vulnerable Populations;women versus men;young adult

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Digestive Diseases;Genetics;HIV/AIDS;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse

PI_NAMEs: EDELMAN, E. JENNIFER (contact)

PROJECT_TERMS: acamprosate;Address;Adoption;Adverse event;adverse outcome;Aging;alcohol abuse therapy;Alcohol consumption;alcohol intervention;alcohol research;alcohol use disorder;Alcoholic Liver Diseases;Alcohols;artificial intelligence method;Baclofen;Big Data;Biological;biomarker evaluation;candidate identification;CD4 Lymphocyte Count;Cirrhosis;Clinical Pharmacists;Clinical Trials;cohort;Collaborations;Communication;comparative effectiveness study;Complex;Coupled;Data;Data Analytics;data cleaning;Disulfiram;drinking;drug repurposing;Effectiveness;electronic health data;Electronic Health Record;Evaluation;Event;explainable artificial intelligence;Exposure to;Family;FDA approved;frailty;gabapentin;gene network;Genes;Genetic;genetic element;Genetic Epistasis;genetic variant;Genetic Variation;genome-wide;Goals;Health behavior;Health Personnel;Healthcare;HIV;improved;indexing;Individual;Injury;innovation;Intervention;Intervention Studies;Link;Liver;Liver diseases;liver injury;Mediating;medication safety;Metformin;Methods;Morbidity - disease rate;mortality;Naltrexone;National Institute on Alcohol Abuse and Alcoholism;novel;Older Population;organ injury;Outcome;Patients;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Physiological;Pilot Projects;pilot trial;Pioglitazone;Polypharmacy;Prazosin;pre-clinical;Productivity;programs;protective effect;Provider;racial diversity;random forest;Recording of previous events;reduced alcohol use;Risk;Risk Assessment;routine care;Safety;Series;Spironolactone;Systems Biology;Time;treatment response;United States Food and Drug Administration;uptake;Variant;Verapamil;Veterans Health Administration;Viral Load result

PROJECT_TITLE: Safety and Effectiveness of Medications for Alcohol Use Disorder among HIV+/-


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences

ORG_CITY: Newark

ORG_DEPT: PSYCHIATRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Cognitive effort avoidance can undermine planning and decision-making, especially in amotivational disorders like schizophrenia and depression. This project will test a promising hypothesis about what the brain treats as costly during task engagement. Understanding what the brain treats as costly will lay the foundation for future work on the nature of subjective effort, and suggest target mechanisms for promoting desirable cognitive effort.

PI_NAMEs: WESTBROOK, JOHN ANDREW (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Address;Brain;Cognitive;Cognitive aging;cognitive load;cognitive task;Computer Models;cost;Data;Decision Making;discount;Disease;Electroencephalography;Equilibrium;experience;Fatigue;flexibility;Foundations;Functional Magnetic Resonance Imaging;Future;Goals;indexing;Individual;Individual Differences;Intervention;Lateral;Link;Mental Depression;Motivation;Nature;neurotransmission;novel;Parietal;Participant;Pathologic;Persons;pharmacologic;Phase;Prefrontal Cortex;Property;Protocols documentation;Rest;Rewards;Schizophrenia;Short-Term Memory;Signal Transduction;skills;Sleep Deprivation;Testing;Theoretical model;Thinking;tool;Training;Transcranial magnetic stimulation;Work

PROJECT_TITLE: Subjective Cognitive Effort Indexes Sub-Criticality in the Brain

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: BOSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Narrative This program trains pre- and post-doctoral quantitative researchers to conceive and conduct cutting-edge methodological and collaborative research in cancer clinical trials, computational biology, cancer genomics, cancer epidemiology and population science. The program also teaches them to become strong team leaders/members, and to be excellent communicators in a cancer research environment, to effectively disseminate research results, and to assume active roles in the design, analysis and interpretation of cancer research projects including cancer genomic studies, cancer clinical trials, and cancer prevention trials.

PI_NAMEs: PARMIGIANI, GIOVANNI LUIGI (contact);QUACKENBUSH, JOHN

PROJECT_TITLE: Training Grant in Quantitative Sciences for Cancer Research

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE We will examine the function of Piezo1, a mechanosensory molecule, to clarify an unexplored critical role of the tendon/ligament in tissue homeostasis and exercise ability. This will open up a new avenue for basic physiology and genetic research and contribute to innovating novel medical strategies for the many common musculoskeletal disorders that result from tendon/ligament injuries or aging-related degradation.

PI_NAMEs: ASAHARA, HIROSHI  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Address;African;African American population;Age;aged;Aging;aging related;Agonist;biomechanical test;Biomechanics;bone;Cartilage;comparison control;Data;Development;Elasticity;Erythrocytes;Exercise;gain of function;gain of function mutation;Gene Expression;Gene Expression Profiling;Genes;Genetic Research;Hereditary Disease;Histologic;Homeostasis;Human;Immobilization;improved;in vivo;Injury;innovation;insight;Ion Channel;Kinetics;knock-down;Knock-in;ligament development;ligament injury;Ligaments;loss of function;Malaria;mature animal;Mechanical Stimulation;mechanical stimulus;mechanotransduction;Mediating;Medical;Modeling;Molecular;molecular phenotype;Morphology;Motor;Movement;Mus;Muscle;Muscle Contraction;Musculoskeletal Diseases;Musculoskeletal System;Mutation;novel;Organ;Pathologic;Performance;Phenotype;Physical Performance;Physiologic Ossification;Physiological;Physiology;Piezo 1 ion channel;Play;postnatal;Property;Reporting;Resistance;response;Role;Signal Transduction;Small Interfering RNA;small molecule;Speed;Stretching;Structure;Sum;Tendon structure;Testing;therapeutic target;Tissues;transcriptome;Translating;transmission process;treadmill;Up-Regulation;Variant;viscoelasticity;Wild Type Mouse

PROJECT_TITLE: Mechano signals regulating tendon and ligament homeostasis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CAMBRIDGE

ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

PHR: Project Narrative Germ cells must maintain their identity for the entirety of a species' reproductive lifespan, a task that can last up to forty years in humans. This unique challenge raises the question: What underlying molecular processes govern germ cell identity and prevent reprogramming toward a somatic cell fate? A multiplex approach proposes to answer this question by (i) identifying factors that are instructive for the germline genetic program, (ii) uncovering how the translational repressor Nanos protects germ cell fate and prevents germline to soma transformation, and (III) addressing the role of small RNAs in germ fate specification and genome protection.

PI_NAMEs: LEHMANN, RUTH  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Address;ATAC-seq;Binding;Binding Sites;Biological Assay;candidate identification;Cell Reprogramming;cell type;Cells;Chromatin;Chromatin Remodeling Factor;Deposition;Development;DNA damage checkpoint;DNA Transposable Elements;egg;Elements;Embryo;Embryonic Development;Enzymes;expectation;experimental study;Face;fly;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Markers;Genetic Transcription;Genome;Germ;Germ Cells;Germ Lines;Goals;Human;Immunity;Inherited;life span;Mediating;member;Methods;Modeling;Molecular;Mus;mutant;Mutation;nano;nanobodies;neuronal cell body;next generation;novel;Oogenesis;Pathway interactions;permissiveness;Phenotype;piRNA;preempt;premature;prevent;Process;programs;Proteins;Regulation;Regulatory Pathway;Reporter;Repression;reproductive;ribosome profiling;RNA;RNA Editing;RNA-Binding Proteins;Role;single-cell RNA sequencing;Site;Small RNA;Somatic Cell;Specific qualifier value;sperm cell;Structure of primordial sex cell;System;Testing;Totipotency;Trans-Activators;Transact;transcription factor;Transcriptional Activation;Transcriptional Regulation;Translational Repression;Translations;transmission process;tumor;Validation

PROJECT_TITLE: Protecting and Sustaining Germ Cell Identity

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative The proposed work will reveal the basic molecular mechanisms that govern ribosome biogenesis and how they contribute to ribosome heterogeneity. Our work will demonstrate how ribosome production is regulated by cellular signaling pathways and how this alters ribosome composition and functionality. Since ribosome biogenesis is misregulated in several disease contexts, a clear understanding of these pathways is essential for the development of targeted therapies.

PI_NAMEs: LYONS, SHAWN M (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Affect;Biogenesis;biological adaptation to stress;Cell Nucleolus;Complex;Development;differential expression;Disease;Event;Genes;genetic information;Genetic Processes;Genetic Transcription;Genome;Heterogeneity;Human;Light;Molecular;molecular subtypes;multiple omics;novel;Nuclear;Oxidative Stress;Pathway interactions;Pharmaceutical Preparations;posttranscriptional;Process;Production;Proteins;Regulation;Ribosomal Proteins;Ribosomal RNA;Ribosomes;RNA Processing;rRNA Genes;Signal Pathway;Site;Stimulus;Stress;targeted treatment;Techniques;Therapeutic;Time;Transcription Process;Variant;Virus Diseases;Work

PROJECT_TITLE: Regulation of Ribosome Biogenesis

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The proposed randomized, double-blind Phase N/A clinical device trial seeks to investigate whether we can improve learning and memory by increasing activity in a part of the brain known to be related to memory by using a non-invasive ultrasound device. All participant will have either a confirmed diagnosis of amnestic mild cognitive impairment, a transition diagnosis between healthy aging and Alzheimer’s disease (AD), or be demographically- well-matched healthy aging controls. Through the integration of multimodal neuroimaging and experimental neuropsychological tasks, we aim to demonstrate that LIFUP can (A) successfully target and increase activity in the targeted memory area and other parts of the brain it is functionally connected to (B) improve connectivity of these memory networks (C) improve morphology of these memory networks (d) improve memory for information (e) determine the effect of different doses and a booster session on the effect of ultrasound on the brain and memory and (f) determine the relationship between blood-based AD biomarkers and LIFUP treatment outcomes.

PI_NAMEs: BOOKHEIMER, SUSAN Y (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Acoustics;Affect;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;amnestic mild cognitive impairment;Anterior;Area;behavior measurement;Behavioral;Biological Markers;Blood;Blood flow;blood-based biomarker;Brain;brain magnetic resonance imaging;Brain region;Cerebrovascular Circulation;Clinical;Clinical Trials;cranium;Data;Deep Brain Stimulation;Devices;Diagnosis;Dose;Double-Blind Method;effective therapy;entorhinal cortex;Episodic memory;Focused Ultrasound;follow-up;Frequencies;Functional Magnetic Resonance Imaging;healthy aging;Hearing;Hippocampus;Human;improved;Learning;Magnetic Resonance Imaging;Measures;Memory;mild cognitive impairment;Morphology;multimodal neuroimaging;neural;neuroimaging;Neuropsychology;neuroregulation;neurosurgery;Operative Surgical Procedures;Participant;Patients;Penetration;Performance;Perfusion;Phase;Population;Prosthesis;Randomized;Rest;Sampling;Site;Structure;Surface;Techniques;temporal measurement;Testing;Thick;Time;Treatment outcome;ultrasound;Up-Regulation;white matter

PROJECT_TITLE: Modulation of Hippocampal Circuitry and Memory Function with Focused Ultrasound in Amnestic MCI


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project narrative The applicant successfully screened large compound libraries for their ability to delay Alzheimer pathology in C. elegans as a model for proteotoxicity in aging, and for their ability to reduce inflammation in microglial cells, implicated in physiopathology of neurodegenerative diseases. She subsequently carried out a pilot feasibility study with Medicare data to validate the results in humans and proposes to expand those results using Medicare data to assess whether the identified protective FDA-approved drugs lower the risk of Alzheimer’s disease and related diseases (ADRD) in humans with a pharmacoepidemiologic approach. The GEMSSTAR award will allow the applicant to increase and improve her knowledge of pharmacoepidemiology with the help of world class specialists in epidemiology, aging and geriatrics at the Icahn School of Medicine at Mount Sinai, helping bridge the gap, thanks to the results of this project, between aging biology and future clinical trials for repurposed drugs in older adults.

PI_NAMEs: LITKE, RACHEL  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: abeta toxicity;adalimumab;Address;age-related disease;Aging;aging related disease;Agreement;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer's disease therapy;Amyloid beta-Protein;Arthritis;Automobile Driving;Award;beneficiary;Biological Assay;Biology of Aging;Caenorhabditis elegans;career;Case/Control Studies;Categories;Cell Culture Techniques;Chronic;Clinical Trials;clinically significant;Crohn's disease;cytokine;Data;Data Set;Databases;demographics;design;Development;Disease;disease diagnosis;drug candidate;drug repurposing;Drug Screening;Drug Targeting;Drug usage;Epidemiologist;Epidemiology;Event;experience;extend lifespan;FDA approved;Feasibility Studies;Functional disorder;Funding;Future;genome wide association study;Geriatrics;Goals;hazard;health record;high-throughput drug screening;Human;Impaired cognition;improved;in vivo;Inflammation;Inflammatory;innovation;interest;Interleukin-6;Investments;Knowledge;Libraries;medical schools;Medicare;Mentors;Methods;Microglia;model organism;Modeling;monocyte;Mus;Muscle;Myelogenous;Neurodegenerative Disorders;novel;older adult;Outcome Measure;Pathology;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacologic;Pharmacologic Substance;Phenothiazines;Phenotype;Pilot Projects;Pioglitazone;Population;population health;Probability;Process;Protective Agents;protective effect;Proteins;proteotoxicity;Protocols documentation;Psoriasis;Recording of previous events;Research;Research Personnel;Risk;Risk Reduction;Safety;safety assessment;Sampling;screening;Source;Specialist;symptom treatment;tau Proteins;Technology;Testing;Therapeutic;Time;TNF gene;Toxic effect;Transgenic Organisms;Translating;Translations;United States Centers for Medicare and Medicaid Services

PROJECT_TITLE: Translating in vivo drug screens to Alzheimer's patients with a pharmaco-epidemiological approach


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cerebrovascular;Dietary Supplements;Endocrine Disruptors;Human Fetal Tissue;Neurosciences;Nutrition;Pediatric;Pregnancy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE At present, very little information exists on protein abundance, localization, and activity of transporters in human placenta, the developing gut, and the developing brain during pregnancy and after birth. We propose a comprehensive approach to address this significant knowledge gap. Such studies are important for a deeper understanding of transporter-mediated disposition and distribution of nutrients, xenobiotics, and dietary supplement constituents in the developing fetus and neonate/infant that impact early development and efficacy of nutrients, toxicity and efficacy of therapeutics or dietary supplements, in these vulnerable populations.

PI_NAMEs: UNADKAT, JASHVANT D;WANG, JOANNE  (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: ABCB1 gene;ABCG2 gene;absorption;Address;Adult;Articulation;ATP-Binding Cassette Transporters;Binding;Biopsy;Birth;Blood - brain barrier anatomy;Brain;brain endothelial cell;Breast Feeding;Carrier Proteins;Cells;Childhood;Clinical;Data;Development;dietary supplements;drug efficacy;Drug or chemical Tissue Distribution;Exposure to;Family;FDA approved;fetal;fetal blood;Fetal Development;Fetus;First Pregnancy Trimester;Folic Acid;Gastrointestinal tract structure;Goals;Growth;HIV;HIV Protease Inhibitors;Human;Human Development;Human Genome;human tissue;Immunohistochemistry;In Vitro;induced pluripotent stem cell;Infant;Ingestion;interest;Intestines;Knowledge;Mediating;Messenger RNA;microphysiology system;Modeling;Mothers;mRNA Expression;neonate;novel;Nutrient;Organ;Organoids;Perfusion;Pharmaceutical Preparations;Physiological;Placenta;Play;Pluripotent Stem Cells;Pregnancy;Pregnant Women;prenatal exposure;Proteins;Proteomics;Role;Saquinavir;Second Pregnancy Trimester;SLC19A1 gene;solute;Tissues;Toxic effect;Transfection;Treatment Efficacy;Universities;uptake;Vascularization;Vitamins;Vulnerable Populations;Washington;Xenobiotics

PROJECT_TITLE: Identification, Quantification, and Functional Characterization of Transporters in Human Placenta, Developing Gut and Fetal Brain


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Overall Component: Project Narrative Advances in medical sciences led to the elucidation of infectious disease mechanisms and clinical translation of potent vaccines and therapies to reduce the death burden from common infections such as polio, meningococcus, and many others that are now almost forgotten in the US because of these successes. Today, in the early 21st century, we are building on the remarkable advances in our mechanistic understanding of the genomic architecture of cancer and its predisposition. The CAP-IT CRI will focus on recent rapid advances in RNA vaccine technology, cancer immune prevention, and interception vaccines that have the potential to substantially reduce the cancer burden in the 21st century.

PI_NAMEs: ALTORKI, NASSER KHALED;LIPKIN, STEVEN M (contact);MCGRAW, TIMOTHY E;MITTAL, VIVEK

PROGRAM_OFFICER_NAME: CLIFFORD, JOHN LEO

PROJECT_TERMS: Antigens;Architecture;Autologous;Award;biobank;Biotechnology;Cancer Burden;cancer genetics;cancer genome;cancer genomics;cancer immunotherapy;cancer predisposition;cancer prevention;cancer risk;Cessation of life;Clinic;Clinical;clinical translation;Clinical Trials;Clonal Evolution;Communicable Diseases;Computer Analysis;COVID-19 vaccine;cytotoxicity test;Data;Databases;Division of Cancer Prevention;efficacy testing;Ensure;experience;flexibility;forgetting;Genomics;Goals;Health Insurance Portability and Accountability Act;Hereditary Nonpolyposis Colorectal Neoplasms;Immune;immune RNA;immunogenic;immunogenicity;Immunologic Surveillance;Immunoprevention;In Vitro;in vivo;in vivo Model;Individual;individualized prevention;Infection;Inherited;innovation;Lesion;lipid nanoparticle;Lung;Lung Adenocarcinoma;Malignant Neoplasms;Medical;mouse model;Neisseria meningitidis;neoantigens;Nodule;patient population;Patients;Poliomyelitis;pre-clinical;Predisposition;Premalignant Neoplasm;Prevention;Prevention strategy;Primary Cancer Prevention;programs;Recording of previous events;Recurrence;Research;Resource Sharing;RNA;RNA vaccination;RNA vaccine;Role;Science;Services;Smoker;success;Syndrome;T-Lymphocyte;Technology;transcriptome;Translating;translational pipeline;tumor;Tumor Antigens;tumor immunology;vaccine discovery;vaccine formulation;Vaccines;Validation;Work

PROJECT_TITLE: CAP-IT Center for LNP RNA Immunoprevention


PI_NAMEs: LIPKIN, STEVEN M (contact)

PROJECT_TERMS: Acceleration;American Association of Cancer Research;American Society of Clinical Oncology;archive data;Automobile Driving;Award;Cancer Center;cancer prevention;Cancer Research Project;cancer risk;Clinical;clinical translation;Clinical Trials;Collaborations;Contracts;Dana-Farber Cancer Institute;data archive;data management;data sharing;Database Management Systems;Databases;Division of Cancer Prevention;Doctor of Philosophy;editorial;Emerging Technologies;Ensure;Evaluation;experience;Genetic Databases;Genomics;Goals;Health Insurance Portability and Accountability Act;Hereditary Nonpolyposis Colorectal Neoplasms;IACUC;Immune Targeting;Immunooncology;Immunoprevention;Individual;individualized prevention;Institute of Medicine (U.S.);Institutional Review Boards;International;Journals;Lead;Leadership;Malignant neoplasm of lung;Medicine;meetings;member;Mission;National Cancer Institute;Patients;pre-clinical;prevent;Prevention Research;Productivity;Program Research Project Grants;programs;Reproduction spores;Research;Research Personnel;Research Project Grants;Resource Sharing;RNA;RNA vaccine;Role;Site;targeted agent;Time;Translating;translational oncology;Translations;tumor immunology;Vaccines;Validation;working group

PROJECT_TITLE: CAP-IT CRI U54 ADMINISTRATIVE CORE


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Immunization;Prevention;Rare Diseases;Vaccine Related

PROJECT_TERMS: Area;Atlases;Award;cancer genetics;Cancer Patient;Cells;Clinical;Clonal Evolution;Collaborations;computerized tools;Data;Data Analyses;Epitopes;experience;genomic data;Genomics;Hereditary Nonpolyposis Colorectal Neoplasms;Immune;immunogenicity;Immunoprevention;improved;innovation;insertion/deletion mutation;Lead;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Mutation;Mutation Analysis;neoantigens;new technology;Nodule;novel;Patients;Premalignant Neoplasm;programs;Proteomics;Research Personnel;Research Project Grants;Research Support;Resource Sharing;RNA;Role;Science;Services;single-cell RNA sequencing;success;The Cancer Genome Atlas;tool;tumor;Tumor Antigens;tumor immunology;vaccine immunogenicity;Vaccines;Validation;working group

PROJECT_TITLE: The Computational Tumor Immunology Core (CTIC)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Immunization;Immunotherapy;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

PROJECT_TERMS: Adenine;adenoma;Affect;American;Amino Acids;Atlases;Autologous;Automobile Driving;Biological Assay;Cancer Burden;cancer genome;Cancer Patient;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Clinical;Clinical Trials;colon cancer cell line;colon cancer patients;Colonic Adenoma;Colorectal Adenocarcinoma;Colorectal Adenoma;Colorectal Cancer;colorectal cancer risk;Correlative Study;COVID-19;cytotoxic;Cytotoxic T-Lymphocytes;Data;Disease;DNA;first-in-human;Future Generations;gene repair;Genomics;Hereditary Nonpolyposis Colorectal Neoplasms;Heterozygote;Human;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immunity;immunogenic;immunogenicity;Immunologics;Immunoprevention;in vivo;insertion/deletion mutation;insight;Malignant Neoplasms;MHC Class I Genes;Microsatellite Instability;Mismatch Repair;Mismatch Repair Deficiency;mouse model;Mus;Mutate;Mutation;nanoparticle;neoantigen vaccine;neoantigens;Normal Cell;Patients;peptide vaccination;Peptides;premalignant;Proteins;Recurrence;repaired;RNA;RNA vaccination;Science;T-Lymphocyte;Technology;Testing;TGFBR2 gene;Transgenic Mice;tumor;Tumor Burden;tumor immunology;Tumor-Infiltrating Lymphocytes;Vaccination;vaccine candidate;vaccine development;Vaccines

PROJECT_TITLE: Lynch Vaccine


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunization;Immunotherapy;Lung;Lung Cancer;Nanotechnology;Prevention;Vaccine Related

PROJECT_TERMS: Adenocarcinoma;antigen-specific T cells;Antigens;Autologous;biobank;Biopsy;cancer immunotherapy;Cancer Model;Cancer Vaccines;Carcinoma;checkpoint therapy;Chest;Clinical;clinical investigation;Clinical Trials;Coculture Techniques;cohort;Collaborations;computerized;computerized tools;Computing Methodologies;Correlative Study;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;density;Detection;Disease Progression;efficacy evaluation;efficacy testing;Exhibits;exome sequencing;experience;Female;Frameshift Mutation;Genomics;Glass;Goals;Human;Image;Immune;Immune checkpoint inhibitor;immune RNA;Immune Targeting;Immunogenetics;immunogenic;immunogenicity;Immunoprevention;Immunosuppression;Impairment;improved;in vivo;Infiltration;insertion/deletion mutation;insight;Intercept;interest;Investigation;Lesion;lipid nanoparticle;Lung;Lung Adenocarcinoma;lung cancer screening;Lung Neoplasms;Lung nodule;lung tumorigenesis;Major Histocompatibility Complex;Malignant neoplasm of lung;manufacture;Methods;MHC Class I Genes;minimally invasive;Modeling;Molecular;mouse model;multi-ethnic;Mus;mutant;Mutation;Mutation Detection;nanoparticle;Natural History;neoantigen vaccination;neoantigens;neoplastic;Nodule;Non-Small-Cell Lung Carcinoma;novel;Operative Surgical Procedures;Ovary;Patients;Peptides;Phenotype;Physiological;Placenta;pre-clinical;preclinical study;premalignant;Prevalence;prevent;Prevention;Process;protein expression;Proteins;Regulatory T-Lymphocyte;Resource Sharing;RNA;RNA vaccine;screening program;Solid;Solid Neoplasm;Source;success;T-Lymphocyte;Testing;Testis;tomography;transcriptomics;Transgenic Mice;tumor;Tumor Antigens;tumor exome;Tumor Immunity;tumor immunology;tumor-immune system interactions;Uncertainty;Vaccination;vaccine candidate;vaccine development;vaccine efficacy;vaccine evaluation;Vaccines

PROJECT_TITLE: Lung Cancer Vaccine


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: TUCSON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Our vision is to develop the first safe, real-time and high resolution system for mapping electricity in the human brain. Transcranial Acoustoelectric Brain Imaging (tABI) would transform our understanding of normal brain function and help diagnose, monitor, and treat a wide variety of neurologic, psychiatric, and behavioral disorders. This collaborative project will assemble a world-class multidisciplinary team to overcome major challenges with detecting weak signals in the brain to deliver a revolutionary and mobile imaging tool for human neuroscience and beyond.

PI_NAMEs: WITTE, RUSSELL S (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: 4D Imaging;Acoustics;Adult;Behavior Disorders;Behavioral;Bite;Brain;Brain imaging;Brain Mapping;Brain region;brain volume;Calibration;Cephalic;Cerebrovascular Circulation;cranium;data acquisition;density;Diagnosis;Disease;Electricity;Electrodes;Electroencephalography;Electrophysiology (science);Elements;Engineering;Epilepsy;Equipment;Evoked Potentials;Excision;Family suidae;Focused Ultrasound;Frequencies;Functional Imaging;Functional Magnetic Resonance Imaging;Goals;Head;healthy volunteer;high resolution imaging;Human;human subject;Image;imager;Imaging Device;imaging platform;improved;in vivo;Intervention;Intractable Epilepsy;Maps;Measures;Mechanics;Mental Depression;Mental disorders;mobile computing;Modality;Modeling;Monitor;Motion;multidisciplinary;Nervous System Disorder;neural;neuroimaging;Neurologic;Neuronavigation;Neurons;Neurosciences;next generation;Noise;novel;Operative Surgical Procedures;Outcome;Parkinson Disease;Patients;Performance;Physiologic pulse;Physiological;porcine model;Positioning Attribute;Positron-Emission Tomography;prototype;Psychologist;radio frequency;Resolution;Scanning;Seizures;sensor;Sensory;Signal Transduction;Somatosensory Evoked Potentials;Speed;Structure;Surface;System;Technology;temporal measurement;Thalamic structure;Time;Ultrasonic Transducer;ultrasound;Validation;Vision

PROJECT_TITLE: 4D Transcranial Acoustoelectric Imaging for High Resolution Functional Mapping of Neuronal Currents


ADMINISTERING_IC: ES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Climate-Related Exposures and Conditions;Lung

PHR: PROJECT NARRATIVE Wildfire episodes are increasing in frequency and intensity due to climate change. The proposed work seeks to fill a surprising knowledge gap: cardiovascular risks following wildfire smoke inhalation. Results from this work can be used to determine biomarkers associated with cardiovascular risk, guide emergency medical management, and inform policy decisions surrounding wildfire smoke exposure.

PI_NAMEs: GONZALEZ, DAVID H (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acceleration;Aerosols;air filter;Air Pollution;Alveolar;alveolar epithelium;Alveolar Macrophages;Animal Model;Appointment;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Atmosphere;atmospheric chemistry;atmospheric processes;Biological Markers;Biology;Biomass;Biometry;Cardiovascular Diseases;cardiovascular effects;cardiovascular risk factor;Cardiovascular system;career development;Cell Culture Techniques;cell type;Cells;Cessation of life;Chelating Agents;Chemicals;Chemistry;Circulation;climate change;comparison control;Complex;cytokine;Diet;Education;Environment;Epithelial Cells;Etiology;Exhibits;Experimental Designs;Experimental Models;Exposure to;Faculty;fine particles;Frequencies;Generations;Goals;hazard;Health;hepcidin;High Fat Diet;Homeostasis;Human;In Vitro;in vivo;indexing;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Inhalation;Inhalation Exposure;insight;Interdisciplinary Study;Iron;Iron Chelation;iron deficiency;Iron Overload;Ischemia;Knock-out;Knockout Mice;Knowledge;Laboratories;Lavage;Lesion;Letters;Link;Liver;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Lung;Macrophage;Mediating;Mediator;Medical emergency;medical schools;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;Mus;Oxidative Stress;Participant;Pathogenicity;Pathway interactions;Phase;Policies;Positioning Attribute;Production;Pulmonary Inflammation;Reactive Oxygen Species;Research;Scheme;Science;skills;Smoke;smoke inhalation;Source;System;Temperature;Testing;Tissue Harvesting;Tissues;Toxic effect;Toxicology;Training;Transition Elements;United States National Institutes of Health;Universities;Water;Wildfire;Work

PROJECT_TITLE: Impact of Biomass Burning Aerosol and Humic-like Substances on Iron Homeostasis and Atherosclerosis


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: White Plains

ORG_NAME: OLIGOMERIX, INC

PHR: Modified Public Health Relevance Section  There is a critical unmet need for a disease-modifying drug for Alzheimer’s disease (AD); of the ten leading causes of death in the United States, only AD cannot be prevented, slowed or cured and is increasing in incidence. This program is highly important because it is designed to fill this need with a disease-modifying drug that, if successful, will have a tremendous impact on the more than 6.5 million Americans who currently have AD (projected to be 12.7 million by 2050) and their caregivers, and will also help reduce the current cost of $321 billion (projected to be $1.1 trillion by 2050) to our nation (Alzheimer's Association 2022 Alzheimer's Disease Facts and Figures). This R44 Phase IIb application is to demonstrate toxicity limiting dosing in animals to enable dosing at sufficient levels to be safe and effective in humans.

PI_NAMEs: MOE, JAMES G. (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: Adverse effects;Adverse event;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;American;Animals;Behavioral;Biological Markers;Canis familiaris;Cardiovascular system;Caregivers;Cause of Death;Clinical;clinical development;Clinical Research;cohort;cost;cost effective;Data;design;Development;Disease;Dose;Dose Limiting;Double-Blind Method;first-in-human;Formulation;Funding;genotoxicity;Goals;healthy volunteer;Human;human study;Humidity;In complete remission;Incidence;inhibitor;innovation;Kilogram;Laboratories;Lung;manufacture;meetings;method development;Mission;Modeling;mouse model;Mutation;National Institute on Aging;Neurofibrillary Tangles;No-Observed-Adverse-Effect Level;novel;Oral;Pharmaceutical Preparations;pharmacokinetic characteristic;pharmacologic;Phase;pre-clinical;preclinical study;Prevalence;prevent;Preventive;Process;Production;programs;Protein Isoforms;public health relevance;Rattus;Reporting;Research;research and development;Research Design;safety study;Self Administration;Series;Serum;small molecule;small molecule inhibitor;Specific qualifier value;stability testing;System;tau aggregation;tau Proteins;Tauopathies;Technology;Test Result;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Studies;Toxic effect;Toxicology;treatment response;United States;Work

PROJECT_TITLE: GMP Production of a Tau Oligomer Inhibitor to Enable Clinical Development forADRD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-P(11)B]


PHR: Principal Investigator: Schlissel, Gavin Project Narrative Animal development and health require accurate cell-cell communication, which relies on diffusible signaling proteins that travel from sender to receiver cells. Communication through signaling proteins can be regulated by tuning the ability of a signaling protein to diffuse from a sender to a receiver cell, although this mode of signaling regulation is under-explored. Here I will use biophysical and synthetic biology tools to understand how signaling proteins travel from their source to their destination, and to probe how tissue-specific or organism-specific variation in the extracellular matrix contribute to accurate signal propagation. K99/R00 Fellowship Application October 2022

PI_NAMEs: SCHLISSEL, GAVIN S (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Adult;Affect;Amalgam;Anatomy;Animals;Binding;Biochemical;biophysical analysis;Biophysics;Cell Communication;Cell Culture Techniques;cell type;Cells;Communication;Destinations;Development;developmental disease;Diffuse;Diffusion;Embryo;Environment;Erinaceidae;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Family;Fellowship;genetic analysis;Genetic Screening;Hair follicle structure;Health;Lipids;long bone;Measures;Mediating;meter;Molecular;morphogens;Morphology;nanoscale;Neural tube;Organism;particle;Pattern;Physiology;Principal Investigator;Protein Family;Proteins;Regulation;SHH gene;Signal Transduction;Signaling Protein;smoothened signaling pathway;Source;sugar;synthetic biology;Tertiary Protein Structure;Testing;Testis;Tissues;tool;Travel;Variant

PROJECT_TITLE: Genetic and biophysical analysis of morphogen gradient formation


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pain Research;Patient Safety;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Preventing chronic post-surgical pain is a public health priority. The purpose of this proposal is to identify a risk phenotype comprised of biologic, psychologic, and social factors for total shoulder arthroplasty. This risk phenotype will be used to predict chronic post-surgical pain so that novel risk stratification and treatment strategies can be developed and tested for this patient population.

PI_NAMEs: GEORGE, STEVEN Z (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Adult;Anatomy;Anesthesia procedures;Area;Biochemical;Biochemical Markers;Biological;Biological Factors;Biological Markers;biopsychosocial;Caring;Characteristics;Chronic;chronic pain;chronic pain management;chronic painful condition;cytokine;Data;Decision Making;Degenerative polyarthritis;Development;economic impact;Effectiveness;effectiveness testing;efficacy trial;experience;Goals;Health;health care service utilization;Healthcare Systems;high risk;Hip region structure;improved;Individual;individualized medicine;Inflammatory;International Classification of Diseases;Intervention;Knee;Knowledge;Literature;Measures;Mission;Modeling;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;Observational Study;Operative Surgical Procedures;opioid use;Orthopedic Surgery;pain chronification;Pain management;Pain Research;Patient Care;patient population;Patients;Perioperative;Phenotype;Physical Function;Population;Postoperative Pain;Postoperative Period;precision medicine;preclinical efficacy;Predictive Factor;Predisposition;prevent;primary outcome;prognostic;Prospective, cohort study;Proxy;psychologic;psychological distress;Psychological Factors;Public Health;public health priorities;Quality of life;repaired;Replacement Arthroplasty;Reporting;Research;Respondent;Risk;Risk Factors;Risk Marker;risk stratification;Rotator Cuff;Shoulder;Shoulder Pain;social factors;social health determinants;Societies;standard of care;Strategic Planning;success;Surveys;Testing;Time;treatment strategy;United States;Work

PROJECT_TITLE: Biopsychosocial Influence on Shoulder Pain

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: EY

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Narrative The proposed program will lead to a novel bifocal objective that will allow fast imaging of neuronal activity in large brain volumes by simultaneous two-photon imaging of shallow and three-photon imaging of deep tissue layers with improved collection efficiency. The technology created in this program will seamlessly integrate two- and three-photon imaging modalities for recording brain activities across a large range of depth simultaneously.

PI_NAMEs: XU, CHRIS  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: 3-Dimensional;Area;Back;Behavior;Brain;Brain imaging;Brain region;brain tissue;brain volume;Cancer Biology;Collection;Complex;Confocal Microscopy;design;fabrication;Fluorescence;Goals;high resolution imaging;Hippocampus;Image;imaging modality;Immunology;improved;in vivo;in vivo imaging;lens;Light;meter;Microscope;Microscopy;Modality;multi-photon;Mus;neural circuit;neuronal circuitry;Neurons;Neurosciences;novel;optical imaging;Optical Methods;Optics;Pathway interactions;Pattern;Penetration;Photons;Physiologic pulse;Population;programs;Resolution;Sampling;Scanning;Signal Transduction;Speed;Technology;Thinness;three photon microscopy;Time;timeline;Tissue imaging;Tissues;two photon microscopy;two-photon

PROJECT_TITLE: A multi-foci objective lens for large scale brain activity recording


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Complementary and Integrative Health;Diabetes;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition

ORG_CITY: JACKSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: PROJECT NARRATIVE Current therapies to treat adverse cardiac remodeling after myocardial infarction (MI) are limited, and novel therapeutic targets are needed. Macrophage-mediated inflammation plays a critical role in normal cardiac remodeling and healing, but excessive inflammation as observed in patients with diabetes mellitus promotes adverse remodeling and development of heart failure. This proposal will test whether macrophage metabolism of lactate and ketones limits macrophage-mediated inflammation in healthy and diabetic mice and may provide new therapeutic strategies for treating MI.

PI_NAMEs: MOUTON, ALAN J (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: 4D Imaging;Acetoacetates;Address;Adult;Affect;angiogenesis;Anti-Inflammatory Agents;Antiinflammatory Effect;Area;Attenuated;Automobile Driving;beta-Hydroxybutyrate;Carbohydrates;Cardiac;cardiogenesis;cardioprotection;Cardiovascular Diseases;chromatin immunoprecipitation;Cicatrix;clinically relevant;comorbidity;Coronary artery;Coupled;Data;Death Rate;Development;Diabetes Mellitus;Diabetic mouse;diabetic patient;Diagnostic;Dose;Echocardiography;Endothelium;Enzymes;Epidemic;Epigenetic Process;Fatty Acids;feeding;Fibroblasts;Fibrosis;Flow Cytometry;Gene Expression;Gene Modified;Genes;Genus Hippocampus;Glucose;glucose metabolism;glucose uptake;Glycolysis;Granulation Tissue;healing;Heart;Heart failure;heart function;Heart Injuries;High Fat Diet;Histones;Hyperglycemia;Impairment;improved;in vivo;Infarction;Inflammation;Inflammatory;Inflammatory Response;Injections;Injury;Interleukin-1 beta;Intervention;Ischemia;ketogenic diet;Ketone Bodies;Ketones;Knockout Mice;Left;Life Style;Ligation;Macrophage;Measures;Mediating;Mediator;Metabolic;Metabolism;metabolomics;Mitochondria;Modification;mortality;mouse model;Mus;Muscle Cells;Myocardial dysfunction;Myocardial Infarction;Necrosis;necrotic tissue;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutic intervention;Outcome;oxidation;Oxidative Phosphorylation;Oxygen;Patients;Persons;pharmacologic;Phase;Phenotype;Play;prevent;preventive intervention;Production;Proliferating;Property;Proteins;Resolution;Risk;Risk Factors;Role;SLC2A1 gene;Sodium Lactate;Sorting;Source;stable isotope;Starvation;Streptozocin;success;succinyl-coenzyme A;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;Transferase;translational model;ultrasound;United States;wound healing

PROJECT_TITLE: Anti-Inflammatory Roles and Macrophage Metabolism of Lactate and Ketones during Myocardial Infarction

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Obesity;Mental Health;Microbiome;Neurosciences;Nutrition;Obesity;Pediatric

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative  Consumption of a Western diet, characterized by foods that are high in saturated fat and refined carbohydrates, is contributing to the increased global prevalence of obesity. A growing body of research indicates that Western diet consumption, particularly when consumed during early life periods of development, is also causally related to memory deficits and other neurocognitive impairments independent of obesity. This proposal is designed to identify the critical developmental periods as well as the neurobiological mechanisms by which early life Western diet consumption imparts long-lasting neurocognitive dysfunction.

PI_NAMEs: HAYES, ANNA MARIE ROSE (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: access restrictions;Acetylcholine;Adolescence;Adolescent;Adult;bacterial genome sequencing;behavior test;Behavioral;Binding;Brain region;Carbohydrates;Child;Childhood;cholinergic;Cognition;Consumption;critical developmental period;Data;design;Development;Diet;dietary;Dietary Factors;Dietary Intervention;Eating;Energy Intake;Episodic memory;experimental study;Fatty acid glycerol esters;fecal transplantation;Fiber;Food;food environment;Functional disorder;Genomics;gut microbiome;Hippocampus;Human;human model;Impaired cognition;Impairment;in vivo;Learning;Life;Link;long term memory;Mediating;Memory;Memory impairment;memory process;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;microbial;microbiome;microbiota transplantation;Modernization;neurobiological mechanism;Neurocognitive;Neurocognitive Deficit;Neuropharmacology;Neurotransmitters;novel;Obesity;Outcome;Performance;pharmacologic;Pharmacotherapy;Phase;Photometry;Population;postnatal;Prevalence;Process;Public Health;Rattus;Reporting;Research;Rodent Model;Role;saturated fat;sensor;Signal Pathway;Signal Transduction;Structure;Study models;sugar;System;Testing;Toddler;Western Blotting;western diet

PROJECT_TITLE: Neurobiological mechanisms of Western diet-induced cognitive dysfunction


ORG_NAME: DANA-FARBER CANCER INST

PHR: NARRATIVE The next frontier in cancer research is early detection and prevention, and my overarching goal is to apply this to myeloma by defining the first steps of disease development and treating it early before symptoms occur. We will redefine the risk factors of race and chronological age based on underlying biological traits. We will identify ancestry risk scores and genomic signatures that increase the risk of developing myeloma in Black individuals and dissect the molecular mechanisms of “effective age” of the tissue of origin (bone marrow).

PI_NAMEs: GHOBRIAL, IRENE M. (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Age;Aging;anti-cancer research;Behavior;Biological;Black Populations;Black race;Bone Marrow;cancer prevention;carcinogenicity;Chronology;Data;Development;Disease;Early Diagnosis;Environment;ethnic diversity;Family history of;Fracture;frontier;genomic signature;Germ Lines;Goals;Hematologic Neoplasms;Hospitalization;Immune;improved;Individual;Inflammation;Kidney Failure;Lead;Link;MALDI-TOF Mass Spectrometry;Molecular;Monoclonal Gammapathies;Monoclonal gammopathy of uncertain significance;Morbidity - disease rate;Multiple Myeloma;Organ;paragon;Participant;Populations at Risk;Prevalence;prevent;Prevention;Process;Proteins;Race;randomized trial;Recording of previous events;Research;Risk;Risk Factors;risk prediction;screening;Symptoms;Testing;Therapeutic Intervention;Tissues;trait

PROJECT_TITLE: Molecular Prediction of Myeloma Initiation Molecular Prediction of Myeloma Initiation


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Congenital Heart Disease;Congenital Structural Anomalies;Electronic Nicotine Delivery Systems;Heart Disease;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Rare Diseases;Social Determinants of Health;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE Congenital heart defects (CHD) are responsible for $6.1 billion dollars in annual healthcare costs, primarily due to acquired cardiovascular complications. Prevention of tobacco use (e.g., e-cigarettes [“vaping”], combustible cigarettes) is critical for the long-term wellbeing of adolescents with CHD, but there are no interventions to prevent vaping among this vulnerable group. This research will adapt and evaluate the first vaping prevention intervention tailored to adolescents with CHD, which may ultimately contribute to enhanced health and wellbeing for CHD survivors.

PI_NAMEs: FOX, KRISTEN R. (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: 3-Dimensional;acceptability and feasibility;Acute;Adherence;Adolescent;Adult;Affect;Age;aged;Area;arm;arterial stiffness;Behavior Therapy;Behavioral;Biological Markers;Blood Pressure;Cardiology;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;career development;Caring;Characteristics;Childhood;cigarette smoking;Clinic;Clinical;combustible cigarette;Congenital Heart Defects;Critical Congenital Heart Defects;Data;design;Development Plans;Disease;Educational Curriculum;Effectiveness;efficacy evaluation;efficacy trial;Electronic cigarette;electronic cigarette use;evidence base;Feedback;Fellowship;Focus Groups;follow-up;Fred Hutchinson Cancer Research Center;Future;Goals;handheld mobile device;Health;Health behavior and outcomes;Health Care Costs;Health Status;Healthcare;High Prevalence;Hypertension;Individual;information gathering;Intervention;intervention effect;Knowledge;life span;Managed Care;Mentorship;Methodology;mHealth;mhealth interventions;Modality;Morbidity - disease rate;multidisciplinary;Ohio;Outcome;Parents;Participant;Pediatric Hospitals;Pediatric Research;perceived stress;Personal Satisfaction;pilot trial;Population;Populations at Risk;Predisposition;preference;prevent;Prevention;Prevention education;Prevention program;preventive intervention;programs;Psychology;Public Health;randomized, clinical trials;Recording of previous events;recruit;Reporting;Research;Research Institute;retention rate;Risk;Risk Factors;satisfaction;Science;Scientist;Self Management;social cognitive theory;sociodemographics;statistics;stress management;stress reduction;Survivors;Teenagers;Time;TNFSF15 gene;Tobacco;tobacco prevention;Training;treatment arm;treatment as usual;Treatment Efficacy;Universities;usability;vaping;Vulnerable Populations;web page;Youth

PROJECT_TITLE: A Tailored mHealth Vaping Prevention Intervention for Adolescents with Congenital Heart Defects

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Dissemination and Implementation Research;Health Services;Hypertension;Kidney Disease;Neurodegenerative;Prevention;Primary Health Care

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Cognitive impairment and dementia are common in older adults. High blood pressure in midlife is associated with cognitive decline and dementia later in life. The purpose of this research is to study interventions to lower blood pressure in primary care real-world settings and their effectiveness to reduce cognitive impairment and dementia. 1

PI_NAMEs: VAZQUEZ, MIGUEL A (contact);VONGPATANASIN, WANPEN

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;adjudication;Age Years;blood pressure control;blood pressure reduction;Cardiovascular system;Caring;Cessation of life;Chronic;Chronic Kidney Failure;Clinical;clinical decision support;clinical practice;Cognitive;cognitive testing;collaboratory;community intervention;Dementia;design;Development;Diabetes Mellitus;Drug Combinations;Effectiveness;effectiveness/implementation study;Electrolytes;Emergency department visit;Enrollment;Ethnic Origin;Event;evidence base;Evidence based intervention;falls;Fracture;future implementation;global health;Goals;Guidelines;hazard;Health system;Healthcare Systems;Home;Home Blood Pressure Monitoring;Hospitalization;Hypertension;Hypotension;Impaired cognition;Incidence;inclusion criteria;insight;instrument;Intervention;Intervention Studies;Intervention Trial;Life;Measures;Medical;Meta-Analysis;middle age;mild cognitive impairment;Modeling;Monitor;older adult;Outcome;Participant;patient subsets;Patients;Pharmaceutical Preparations;Pharmacists;Population Heterogeneity;Pragmatic clinical trial;pragmatic trial;prevent;Primary Care;primary care practice;primary care setting;primary outcome;Professional Organizations;Quality of life;Randomized;recruit;Research;research clinical testing;Sample Size;secondary outcome;socioeconomics;Syncope;systems research;team-based care;Testing;Titrations;treatment as usual;United States National Institutes of Health;usual care arm

PROJECT_TITLE: Preventing Cognitive Decline by Reducing BP Target Trial (PCOT)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Hematology;Neurosciences;Nutrition;Women's Health Research

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Project Narrative We have demonstrated that women with iron deficiency anemia have profound impairment of basic brain energetics and cognitive function. We will characterize the relative importance of iron deficiency versus the anemia in determining brain blood flow, metabolism, functional connectivity and performance. We will evaluate the magnitude and duration of treatment response to intravenous and oral iron therapy.

PI_NAMEs: WOOD, JOHN C (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Address;Adult;Adult women;Age;Anemia;Area;arm;Benign;Biological Markers;Blood;Blood - brain barrier anatomy;Blood capillaries;Blood flow;blood product;Blood Vessels;blood-brain barrier function;blood-brain barrier permeabilization;Brain;brain iron;Brain region;Caring;Carrying Capacities;cerebrovascular;Cerebrovascular Circulation;cerebrovascular reactivity;Cerebrum;Child;Childhood;Cognition;Cognitive;Cognitive deficits;cognitive function;cohort;competitive environment;Data;Deposition;Development;Diabetes Mellitus;Diagnosis;effectiveness clinical trial;Electron Transport;Employment;endometriosis;Exclusion;Fibroid Tumor;follow-up;General Population;global health;Goals;gray matter;hazard;Hemoglobin;Hemoglobin concentration result;Hemorrhage;Hippocampus;Hispanic Women;Hypertension;Impaired cognition;Impairment;improved;Individual;insight;Intelligence;Intervention;Intestinal Absorption;Intravenous;Iron;iron deficiency;Iron deficiency anemia;Knowledge;Liquid substance;Literature;Los Angeles;Magnetic Resonance Imaging;Medical;medical attention;Memory;Menstruation;Metabolic;metabolic rate;Metabolism;Microvascular Dysfunction;middle age;Minority Groups;Mitochondria;Monitor;Moods;morphometry;National Health and Nutrition Examination Survey;Neurocognition;Neurocognitive;Neurocognitive Deficit;neurocognitive test;neurogenesis;Neurons;Neurosciences;Oral;Oxygen;Oxygen Consumption;Patient Outcomes Assessments;Patients;Performance;Perfusion;Permeability;Persons;Phenotype;Physicians;Physiological;Population;Primary Care Physician;primary endpoint;primary outcome;Randomized;Recording of previous events;recruit;Regulation;Replacement Therapy;Reporting;response;restoration;Risk Factors;screening;Service delivery model;Severities;Sleep;Sleep Apnea Syndromes;social media;standard of care;Surface;Synapses;therapy duration;tissue oxygenation;Toxic effect;treatment duration;treatment response;United States;verbal;Verbal Learning;Visual;Visuospatial;Water;white matter;white matter damage;Woman;women's treatment;Work

PROJECT_TITLE: Brain blood flow, oxygenation, and cognition in adult onset iron deficiency anemia

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cardiovascular;Clinical Research;Genetic Testing;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Precision Medicine;Prevention

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE Familial hypercholesterolemia (FH) is an important contributor to clinical severe hypercholesterolemia and subsequent coronary artery disease (CAD). While discoveries of key causal genes (PCSK9, APOB, and LDLR) have enabled us to molecularly diagnose individuals with FH and provide preemptive treatment to prevent CAD, the yield of genetic diagnosis is still limited. This proposal aims to extend our knowledge of the causal genes and variants for FH to improve the prevention and management of CAD.

PI_NAMEs: KOYAMA, SATOSHI  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Address;Age;All of Us Research Program;Alleles;Applied Skills;Atherosclerosis;biobank;Biological Assay;Boston;Cardiology;Cardiovascular Diseases;causal variant;Cause of Death;Cholesterol;Clinical;Cloud Computing;Code;cohort;Collaborations;Complex;Coronary Arteriosclerosis;Data;data access;data handling;Data Set;Dedications;Diagnosis;Diagnostic;diagnostic criteria;Diagnostic Sensitivity;Disease;Disease-Free Survival;disorder prevention;Early Diagnosis;Early Intervention;Early treatment;exome;exome sequencing;experience;Exposure to;Familial Hypercholesterolemia;Family;family management;General Hospitals;Generations;Genes;Genetic;genetic analysis;genetic disorder diagnosis;genetic epidemiology;genetic predictors;Genetic Research;Genetic Risk;Genetic Screening;genetic testing;genetic variant;genome sequencing;genome-wide;Genomic medicine;Genomics;Genotype;Guidelines;Hand;Healthcare;Heritability;high risk population;Human Genetics;hypercholesterolemia;Hyperlipidemia;improved;in silico;In Vitro;Individual;Inherited;insight;Institution;Investigation;Investments;Knowledge;LDL Cholesterol Lipoproteins;Lipids;Machine Learning;machine learning method;Massachusetts;Mentors;Mentorship;Methods;Modeling;Molecular Biology;Molecular Diagnosis;Mutagenesis;Mutation;mutation carrier;National Heart, Lung, and Blood Institute;novel;novel diagnostics;Pathogenesis;Persons;Phase;Physicians;polygenic risk score;Population;precision medicine;premature;prevent;Prevention;Preventive;Principal Investigator;programs;Recommendation;Research;Research Personnel;Resources;Risk;Risk Factors;risk prediction;risk stratification;risk variant;Scientist;skills;Statistical Methods;Technical Expertise;Therapeutic;trait;Trans-Omics for Precision Medicine;translational genomics;United States Department of Veterans Affairs;United States National Institutes of Health;Untranslated RNA;Update;Variant;Veterans;whole genome

PROJECT_TITLE: Whole genome sequence interpretation for lipids to discover new genes and mechanisms for coronary artery disease

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(MA)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Methamphetamine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: 220.8 PROJECT NARRATIVE Latino men who have sex with men (LMSM) face one of the largest disparities in new HIV diagnoses nationally, likely because they face intersectional stigma towards their ethnic, sexual, and gender identities (i.e. adherence to masculinity norms) which negatively affects both methamphetamine use and PrEP cascade progression. Social network analysis employing longitudinal multilevel structural equation modeling is an innovative method for studying how intersectional stigma is experienced by members of LMSM’s social network and can differentiate between which network members and under what social contexts stigma reduction interventions could decrease methamphetamine use risk and improve PrEP cascade progression to reduce HIV incidence. Through this K01, Dr. Algarin will leverage the UCSD training infrastructure to build his professional independence and skills for promoting HIV prevention in medically marginalized groups, positioning him as a leader among the next generation of under-represented minority scholars to end the HIV epidemic among MSM of color disproportionately burdened by HIV in the US.

PI_NAMEs: ALGARIN, ANGEL B (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;Adherence;Affect;AIDS prevention;Behavior;Buffers;Color;Communities;community engaged approach;community engaged intervention;community engagement;Complex;coping;cultural values;Data;Development;Disparity;Enrollment;Epidemic;Equation;Ethics;ethnic identity;Ethnic Origin;experience;Face;Family;Family member;forging;Friends;Future;Gays;Gender Identity;Goals;Health;HIV;HIV diagnosis;HIV disparities;HIV Infections;HIV risk;Human immunodeficiency virus test;improved;Incidence;innovation;Intervention;Laboratories;Latino;Link;marginalized population;Mediation;Mediator;Medical;member;men who have sex with men;Methamphetamine;methamphetamine use;Methods;Modeling;next generation;NIH Office of AIDS Research;novel;Outcome;Pathway Analysis;Pathway interactions;Positioning Attribute;pre-exposure prophylaxis;preventive intervention;Process;prospective;Race;Research;Research Priority;resilience;Resistance;Risk;Risk Behaviors;sexual identity;Sexuality;skills;social;Social Environment;Social Network;social stigma;Social support;Source;Stigmatization;stimulant use;substance use;Techniques;Testing;theories;therapy development;Training;Training and Infrastructure;Underrepresented Minority;uptake

PROJECT_TITLE: Addressing intersectional stigma through coping, resistance, and resilience to improve methamphetamine use and factors influencing PrEP uptake among Latino MSM: a step towards ending HIV by 2030

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE Estrogen deficiency and old age are the two most important factors for bone loss and the development of osteoporosis in both women and men, but the mechanisms responsible for this effect remain unclear. The aim of the work proposed in this application is to uncover the underlying mechanisms and this will be accomplished by studying a mitochondrial deacetylase Sirt3 and its downstream effectors in osteoclasts. Knowledge gained with these studies may prove useful for the development of therapies that can treat osteoporosis.

PI_NAMEs: KIM, HA-NEUI  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Ablation;Acetylation;Affect;age related;age-related disease;aged;Aging;Architecture;ATP phosphohydrolase;Attenuated;Biogenesis;Biological;Biology;bone;bone cell;Bone Diseases;bone loss;bone mass;Bone Resorption;Cells;conditional knockout;Deacetylase;Deacetylation;Development;Disease;Estrogen Activity Inhibition;Estrogen deficiency;Exhibits;Generations;Genetic;Health;Homeostasis;Human;human old age (65+);Impairment;In Vitro;in vivo;inhibitor;innovation;Ionizing radiation;knock-down;Knockout Mice;Knowledge;loss of function;Lysine;Mediating;men;Metabolic Diseases;Mitochondria;mitochondrial metabolism;Mitochondrial Proteins;Molecular;Mus;mutant;Mutate;neurotensin mimic 1;novel;Organ Culture Techniques;Organelles;Osteoblasts;osteoclast progenitor;Osteoclasts;Osteoporosis;Ovariectomy;overexpression;Oxidative Stress;Pathology;pharmacologic;Phenotype;Physiological;PINK1 gene;Play;Post-Translational Regulation;prevent;Process;protective effect;Proteins;Proteomics;PTEN gene;Quality Control;Radiation exposure;Reporter;Respiration;Role;Sirtuins;Site;skeletal;Structure;Testing;therapy development;Transgenes;Tubular formation;Woman;Work

PROJECT_TITLE: Role of Mitochondrial Quality Control in Bone Homeostasis and Disease

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: COLLEGE PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative This multi-method project examines developmental differences in the prevalence and mechanisms of alcohol use among adolescents with diverse sexual orientations and gender identities. Through strategic dissemination efforts, the results of this project will address pressing public health concerns regarding sexual and gender minority youth alcohol use. The corresponding training plan will launch the career of an early career scholar poised to make substantial contributions to understanding the mutable factors implicated in sexual and gender minority youth’s alcohol use and misuse.

PI_NAMEs: BISHOP, MEG  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Adolescence;Adolescent;Age;Alcohol consumption;alcohol epidemiology;alcohol misuse;alcohol risk;Alcohols;Area;Asian;Attenuated;attenuation;Automobile Driving;binge drinking;Black race;bullying;California;career;Child;children of color;cisgender;community organizations;Complex;critical period;Data;Data Collection;Data Set;Data Sources;Development;Disparity;diverse data;eleventh grade;Environment;Ethnic Origin;Etiology;experience;Family;Gender Identity;gender minority youth;Generations;Goals;health inequalities;Heterosexuals;Hispanic;Inequity;innovation;Interruption;Intervention;Interview;Lesbian Gay Bisexual;Life Cycle Stages;Mentored Research Scientist Development Award;Mentorship;Methods;minority children;minority stress;Pathway interactions;peer;peer influence;Perception;Persons;population based;Prevalence;Prevention;Public Health;Race;Reporting;Research;Research Personnel;resilience;Resources;Role;Scholarship;seventh grade;sex;Sex Orientation;sex variable;sexual minority youth;Shapes;skills;Social Identification;social norm;social stigma;Source;stem;Stress;stressor;Surveys;Teenagers;Training;transgender;Translating;trend;underage drinking;United States;Youth

PROJECT_TITLE: Sexual orientation, gender identity, and alcohol use: A multi-method analysis of developmental differences and key mechanisms


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

PHR: Project Narrative Most Alzheimer’s disease (AD) risk genes, including the R47H mutation of the Trem2 receptor and the APOE4 allele, are found in microglia, pointing to a causal role for microglia in neurodegeneration. This study examines the interactions between risk factors R47H and APOE4 to elucidate the microglial Trem2-APOE pathway’s effects on cellular metabolism and inflammation and to evaluate the mechanistic role of AKT in this pathway. Better understanding the Trem2-APOE pathway will expose mechanisms of microglia-driven neurodegeneration in AD and identify new therapeutic targets for its treatment.

PI_NAMEs: CARLING, GILLIAN KIROVA (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Acceleration;Affect;Affinity;Age;AKT inhibition;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;apolipoprotein E-3;apolipoprotein E-4;Automobile Driving;Biomass;Clinical Trials;cognitive function;Data;Dementia;Development;Disease;Disease Progression;disorder risk;experimental study;functional outcomes;gene interaction;Genetic Risk;genetic risk factor;Genotype;Health;human old age (65+);Impaired cognition;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Ligands;Link;Lipoproteins;Measures;Memory impairment;Metabolic;Metabolism;metabolomics;Microglia;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;Mus;Mutation;Nerve Degeneration;Neurofibrillary Tangles;neuroinflammation;new therapeutic target;novel;Onset of illness;Pathogenesis;Pathology;Pathway interactions;Persons;Phenotype;Phosphotransferases;Play;Population;Production;Proto-Oncogene Proteins c-akt;Reactive Oxygen Species;receptor;Research;Respiration;response;Risk Factors;risk variant;Role;Senile Plaques;Signal Transduction;Synaptophysin;tau mutation;tau Proteins;Tauopathies;Therapeutic Effect;Toxic effect;transcriptomics;TREM2 gene;Variant

PROJECT_TITLE: Trem2-APOE Pathway in Alzheimer's Disease: Exploring the differential effects of R47H on the APOE3 and APOE4 backgrounds in a tauopathy model


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative African American (AA) women who are young (less than age 45) are more likely to develop breast cancer, report poorer quality of life (QOL), and face negative social determinants of health (e.g., low socioeconomic status, limited access to care, discrimination) than young White women. This two-arm study will evaluate feasibility, acceptability, and preliminary outcomes of Y-AMBIENT (a targeted and telephone-based QOL intervention for young African American survivors of stage I-III breast cancer) vs. an enhanced usual care control (scripted socialization). Findings will inform a randomized controlled trial to test intervention efficacy.

PI_NAMEs: NOLAN, TIMIYA S (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: acceptability and feasibility;Address;Affect;African American;African American Women;Age;anxiety reduction;arm;Attention;attentional control;Audiotape;Award;biobehavior;Breast Cancer Education;Breast Cancer survivor;Breast Cancer Treatment;Cancer Burden;Cancer Survivorship;career;career development;Child;Chronic;college;Communication;comorbidity;contextual factors;Development;Discipline of Nursing;Discrimination;Disease;Disparity;Disparity population;Disproportionately impacts women;early onset;Early treatment;Education;Educational Intervention;efficacy trial;Eligibility Determination;Enrollment;evidence base;Evidence based intervention;experience;Face;follow-up;Foundations;Future;global health;Goals;Guidelines;Health;Health Disparities Research;Health Personnel;Health Promotion;Health Services Accessibility;Image;improved;Insurance;Intervention;intervention delivery;Knowledge;Late Effects;Latina Population;Life;Lived experience;low socioeconomic status;Malignant Breast Neoplasm;Malignant Neoplasms;Manuscripts;Measures;Mentors;Methods;Minority Groups;Modeling;Nurses;Ohio;Outcome;Participant;Patients;Perception;phenomenological models;Policies;post intervention;preference;primary outcome;Procedures;Process;professor;programs;Protocols documentation;psychologic;psychosocial outcome;public health priorities;Publishing;Quality of life;Race;Randomized, Controlled Trials;Recommendation;Recording of previous events;recruit;Reporting;Research;Resources;response;Sample Size;satisfaction;Scientist;Self Efficacy;Self Management;skills;social;social cognitive theory;social health determinants;Social support;Socialization;Spiritual well-being;Spirituality;stressor;Surveys;Survivors;survivorship;Techniques;telephone based;Testing;Time;Translating;Translations;treatment as usual;Treatment Efficacy;two-arm study;Underrepresented Minority;Universities;White Women;willingness;Writing

PROJECT_TITLE: Piloting Y-AMBIENT: A Quality of Life Intervention for Young African American Breast Cancer Survivors in Treatment

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Cancer;Regenerative Medicine

ORG_CITY: STANFORD

ORG_DEPT: UROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative We previously established the detailed molecular mechanisms by which the lipid-modified Hedgehog protein signal is exported by producing cells and by which the signal is sensed and transmitted to the interior of other target cells. Here we propose to determine how these activities are powered by metal cation gradients, how the exported Hedgehog signal is packaged, and how its tissue-level activity is inhibited by a disease-associated sponge-like binding protein, Hhip (Hedgehog interacting protein). Our results are expected to provide a basis for new approaches to modulating Hh pathway activity for therapeutic purposes.

PI_NAMEs: BEACHY, PHILIP A (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Acceleration;Address;Adult;Affinity;Anatomy;antagonist;Basal cell carcinoma;Binding;Binding Proteins;Biochemical;Biological;Biological Assay;Bladder;Blood - brain barrier anatomy;bone;bone repair;cancer therapy;Cations;Cause of Death;Cell membrane;cell type;Cells;Cholesterol;Chronic;Chronic Obstructive Pulmonary Disease;Cilia;Complex;Cryoelectron Microscopy;Disease;Down's Syndrome;embryo tissue;Embryonic Pattern Specification;Energy-Generating Resources;Erinaceidae;Event;Family;Family member;Funding;G-Protein-Coupled Receptors;hedgehog signal transduction;Hydrophobicity;In Vitro;in vivo;Inflammatory Bowel Diseases;inhibitor;Injury;Intestines;Ligands;Link;Lipids;Lung;Maintenance;Malignant Neoplasms;Measures;Mediating;member;Membrane;Metals;Molecular;Molecular Conformation;morphogens;muscle repair;nanobodies;Natural regeneration;neoplastic cell;novel;novel strategies;Organ;Pancreas;Pathology;Pathway interactions;Pattern;Pharmaceutical Preparations;Play;polypeptide;Porifera;Postembryonic;prevent;Primary Neoplasm;Proliferating;protein complex;Protein Inhibition;protein protein interaction;protein structure;Proteins;receptor;receptor function;regenerative;Regulation;resistance mutation;Resolution;Role;SHH gene;Signal Induction;Signal Pathway;Signal Transduction;Signaling Protein;Site;smoothened signaling pathway;Specific qualifier value;stem cells;Sterols;Structure;Surface;Therapeutic;Tissue Differentiation;tissue stem cells;Tissues;Transducers;transmission process;tumor;tumor growth;tumor progression;Work

PROJECT_TITLE: Molecular mechanisms of Hedgehog receptor function

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Cancer;Genetics;Ovarian Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Women's Health Research

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The objective of this proposal is to understand the role of the tumor suppressor protein p53 in aiding cell fate transitions including cancer. As p53 mutants dominate the mutational landscape of cancer, it is important to understand what functions of normal p53 are co-opted and enhanced by mutants to promote cell fate transitions in order to establish effective therapies that target cells harboring these oncogenes. By studying the role of p53 and p53 mutants during transitions, this work will shed light on early-stage cancers, aiding early- detection of the disease and improving patient outcomes.

PI_NAMEs: BEITZ, ADAM MATTHEW (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Address;Adopted;Attention;Back;Behavior;Binding;Bypass;cancer initiation;Cancer Model;Cancerous;carcinogenesis;Cell Differentiation process;Cell Fraction;Cell Reprogramming;Cell Separation;cell type;Cells;design;Diagnosis;Disease;DNA Binding Domain;Early Diagnosis;Ectoderm;effective therapy;Endoderm;Engineering;enhancing factor;Epigenetic Process;Epithelial Cells;Epithelium;Event;Fibroblasts;Frequencies;gain of function;Generations;Genes;Genetic Transcription;Genomics;Human Development;human induced pluripotent stem cells;Immune;improved;induced pluripotent stem cell;Investigation;Lead;Link;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Mammary Gland Parenchyma;Maps;Mediating;Mesoderm;Modeling;Molecular;Motor Neurons;Mus;mutant;Mutate;Mutation;Neoplasm Metastasis;Neurons;Oncogenes;Oncogenic;Organism;Organoids;Outcome;overexpression;Patient-Focused Outcomes;Phase;Phenotype;pluripotent stem cell differentiation;Point Mutation;Postdoctoral Fellow;prevent;Process;programs;Proliferating;Proteins;Regulation;Reporter;Reporting;Research;Role;Sampling;sensor;Skin;small hairpin RNA;Somatic Cell;Stains;stem cell fate;stem cell fate specification;stem cells;success;Synthetic Genes;System;targeted treatment;Therapeutic;three-dimensional modeling;Tissues;TP53 gene;transcription factor;trend;tumor;tumor initiation;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Work

PROJECT_TITLE: Mapping p53 dynamics to cell-fate outcomes in reprogramming and oncogenesis


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Social Determinants of Health;Telehealth

PHR: 8. Project Narrative. Changing sedentary lifestyles, and sustaining change, has huge potential benefits to cardiovascular health and well-being; yet it is notoriously difficult. The current proposal tests whether a sustainable first step towards change in a highly sedentary, high-risk population is teaching behavior change techniques within a socially supportive peer-coaching group, with the goal of interrupting prolonged sitting with short, 2-4 minute bouts of moderate physical activity (exercise snacks). The intervention platform is low-cost, highly scalable, accessible, and socially supported, and teaches evidence-based behavior change techniques to empower people with the tools to make and sustain change.

PI_NAMEs: OPPEZZO, MARILY  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Adult;Age;American;animation;arm;behavior change;Behavior Therapy;Benchmarking;Body Weight;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cartoons;Cause of Death;Clinical;clinically significant;Communication;comparison control;comparison intervention;Consent;Control Groups;cost;Data;Detection;Dropout;Education;Educational process of instructing;effective intervention;Effectiveness;efficacy testing;efficacy trial;Eligibility Determination;Employee;empowerment;Ensure;Ethnic Origin;evidence base;Exercise;experimental study;fitbit;fitness;follow-up;Funding;Goals;Grant;Health care facility;Healthcare;high risk population;Hour;innovation;Interruption;Intervention;Interview;Knowledge;Learning;Length;Libraries;Maintenance;Measurement;Modeling;Moderate Exercise;moderate-to-vigorous physical activity;Monitor;Motivation;Movement;National Heart, Lung, and Blood Institute;Noise;novel;Occupational;Occupations;Outcome;Participant;Patient Recruitments;Patients;peer coaching;peer support;Personal Satisfaction;Persons;Phase;phase III trial;Physical activity;pilot trial;Population;Positioning Attribute;premature;Privatization;professional atmosphere;programs;Race;Randomized;recruit;remote delivery;Research;Research Personnel;Risk;Risk Factors;Role;Running;sedentary;sedentary lifestyle;Series;Signal Transduction;social;social media;Social support;Somatotype;study population;Support Groups;Target Populations;Techniques;Testing;Text Messaging;tool;treatment group;United States National Institutes of Health;vigorous intensity;Wages;Women's Group;Work

PROJECT_TITLE: Move Often eVery Day (MOV'D): An occupationally-tailored, remotely-delivered, socially-supported short exercise break intervention to decrease sedentary behavior in receptionist office staff

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]


ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: RELEVANCE TO PUBLIC HEALTH This project introduces and investigates the scientific premise that age-related reductions in walking performance and economy have been mistakenly attributed solely to muscles spanning the ankle, and instead originate interdependently with unfavorable changes in the active, passive, and structural regulation of foot stiffness and power. Accordingly, the translational purpose of this proposal is to test the efficacy of shoe stiffness modifications to augment foot structure and function in aging and thereby improve gait performance and reduce metabolic energy cost during walking in older adults. Ultimately, this project addresses the need for new and modifiable targets to enhance mobility and independence – paving the way for feasible and cost-effective assistive devices for millions in our aging population.

PI_NAMEs: FRANZ, JASON R (contact);TAKAHASHI, KOTA

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: achilles tendon;Address;Affect;age effect;age related;age related changes;Aging;aging population;Ankle;ankle joint;aponeurosis;Benchmarking;Bioenergetics;Biomechanics;carbon fiber;Clinical;Clinical Management;cost;cost comparison;cost effective;Data;design;Devices;Distal;efficacy testing;Elastic Tissue;Elasticity;electromyographic biofeedback;Energy consumption;Exhibits;Flexor;foot;Foot joint structure;Functional impairment;Gait;Generations;Human;improved;improved mobility;in vivo;insight;Institution;Intramuscular;joint function;joint stiffness;Locomotion;Measurable;Measurement;mechanical energy;Mechanics;Metabolic;Metatarsal bone structure;Mobility decline;Modeling;Modification;Motor Activity;Muscle;muscle strength;novel;older adult;Outcome;Output;peer;Performance;Phalanx;Phase;Play;Productivity;Public Health;Quality of life;quantification of aging;Regulation;Research;Research Infrastructure;Research Personnel;response;Role;Self-Help Devices;Series;Shoes;Speed;strength training;Structure;System;Testing;Tissue imaging;translational potential;Translations;transmission process;Ultrasonography;Walking;walking performance;Work;young adult

PROJECT_TITLE: A framework for feasible translation to enhance foot and ankle function in aging and mobility

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]