NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Available treatment modalities for glaucoma rely on lowering intraocular pressure, which is insufficient to prevent progressive neurodegeneration in a significant number of patients. Building upon our previous studies, this proposal seeks to characterize the mechanism behind glucagon-like peptide-1 receptor (GLP-1R) agonist- mediated retinal ganglion cell rescue in ocular hypertension, and to model the GLP-1R agonist NLY01 as a disease modifying agent in mouse models of glaucoma. Results will advance our understanding of glaucoma pathogenesis, identify the mechanisms driving GLP-1R agonist-mediated neural rescue, and elucidate the potential for GLP-1R agonists as a novel IOP-independent treatment for glaucoma.

PI_NAMEs: CUI, QI N (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Agonist;Antiinflammatory Effect;Astrocytes;astrogliosis;Automobile Driving;Blindness;Body Weight decreased;Brain;Cell Death;Cell Physiology;Cell Survival;cell type;Cells;Chronic;Circulation;Clinical Trials;Complement 1q;Complement 3;cytokine;Cytoprotection;Data;Diabetes Mellitus;diabetic patient;Disease;Disease Progression;dopaminergic neuron;experimental study;Eye;FDA approved;fighting;Fluorescein-5-isothiocyanate;Generations;Genetic;Glaucoma;GLP-I receptor;hazard;Human;hypertensive;Immunohistochemistry;In Situ Hybridization;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory Response;Inherited;insurance claims;Interleukin-1 alpha;intravitreal injection;Knockout Mice;Knowledge;Macrophage;Macrophage Activation;Maps;Measures;Mediating;Mediator;Microglia;Microspheres;mimetics;Modality;Modeling;mouse model;Mus;Myeloid Cells;Nature;Nerve Degeneration;neural;Neurodegenerative Disorders;neuroinflammation;neuron loss;neuronal cell body;Neurons;neuroprotection;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Ocular Hypertension;Optic Disk;Parkinson Disease;Pathogenesis;Patients;Phenotype;Physiologic Intraocular Pressure;preservation;prevent;Process;Production;progressive neurodegeneration;Receptor Activation;receptor expression;response;Retina;retinal ganglion cell degeneration;Retinal Ganglion Cells;Risk;Signal Transduction;symptomatic improvement;targeted treatment;Testing;Therapeutic;TNF gene;tool;Translations;treatment strategy

PROJECT_TITLE: Evaluating Mechanisms and Therapeutic Potential of (GLP-1R) Agonists for Glaucoma Treatment

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging;Digestive Diseases;Liver Disease

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative XMAN will be the first of its kind to provide a realistic and complete simulation of patient imaging and motions in the entire RT workflow, providing essential tools to evaluate and optimize the motion management strategies. Patient-specific XMAN unlocks the potential to move from current population-based heuristic approaches into high-precision patient-specific motion management. Overall, XMAN can lead to a paradigm shift in our motion management of liver SBRT to significantly advance its precision and clinical outcomes.

PI_NAMEs: REN, LEI  (contact);YANG, XIAOFENG

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: 3-Dimensional;abdominal CT;Address;Affect;Algorithms;alternative treatment;Atlases;Award;Bicycling;Breathing;cancer radiation therapy;Cessation of life;Cirrhosis;Clinical;Collaborations;cone-beam computed tomography;Data;Databases;digital;Dose;Dose Limiting;efficacy evaluation;Elements;Ensure;Evaluation;Failure;Grant;heuristics;Image;Imaging Phantoms;Impairment;improved;improved outcome;Individual;individual patient;Industry;industry partner;Institution;invention;Licensing;Liver;liver cancer patient;Malignant neoplasm of liver;Modeling;Motion;Normal tissue morphology;novel;Operative Surgical Procedures;Outcome;Patient imaging;Patient Simulation;patient variability;Patients;Pattern;personalized strategies;Photons;population based;Process;proton therapy;Protons;Publications;Publishing;radiation delivery;Radiation Dose Unit;Radiation therapy;respiratory;Risk;Roentgen Rays;simulation;soft tissue;success;Techniques;therapy outcome;tool;Toxic effect;Translating;treatment optimization;Treatment outcome;treatment planning;tumor;Tumor Volume;Unresectable;virtual clinical trial;X-Ray Computed Tomography

PROJECT_TITLE: eXtended Modular ANthropomorphic (XMAN) phantom for Imaging and Treatment Optimization in Radiotherapy.


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Vaccine Related

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: NARRATIVE The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected over 233 million people globally. The US alone has reported ~126,000 corona virus disease-19 (COVID-19) cases in pregnant individuals, not including many asymptomatic and unconfirmed cases. Thus, potentially millions of children worldwide may be impacted by the sequelae of prenatal SARS-CoV-2 exposure. In this project, we will investigate the association of prenatal exposure to SARS-CoV-2 infection and the COVID-19 vaccines with behavior, cognition, and brain functioning in the child at 3 years of age.

PI_NAMEs: ROMMEL, ANNA-SOPHIE  (contact)

PROGRAM_OFFICER_NAME: LEE, SONIA S

PROJECT_TERMS: 2019-nCoV;3 year old;Accounting;Age;Animal Experimentation;Animals;Antibody titer measurement;Attention;Auditory Evoked Potentials;autism spectrum disorder;autism symptoms;Behavior;Behavioral;Birth;Blood;Blood specimen;Brain;Categories;Child;Child Behavior Checklist;Child Development;Childhood;Circulation;Clinical Data;Cognition;Cognitive;cohort;cost effective;COVID-19;COVID-19 vaccination;COVID-19 vaccine;cytokine;Data;Development;Disease;Dryness;Electroencephalography;Enrollment;epidemiology study;Ethnic Origin;Event-Related Potentials;Exploratory Behavior;Exposure to;Face;Family history of;fetal;Fever;follow-up;Foundations;Funding;Generations;global health;Health system;Immune;Immune response;Immune system;Immunoglobulin G;Impairment;in utero;indexing;Individual;Individuation;Infection;Inflammation;Inflammatory;Lead;Light;Link;Long-Term Effects;Measures;Mediating;Memory;Mothers;Motor;Neonatal;neonate;neural;neurodevelopment;Neurodevelopmental Disorder;neurophysiology;Neuropsychology;New York City;offspring;Outcome;pandemic disease;pathogen;Pattern;Perception;Persons;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Preschool Child;prospective;Questionnaires;Race;Reporting;Risk;SARS-CoV-2 antibody;SARS-CoV-2 exposure;SARS-CoV-2 infection;Severities;sex;social;social disparities;Social Interaction;Socioeconomic Status;socioeconomics;Spottings;Testing;unvaccinated;Vaccinated;Vaccination;Vaccines;Virus Diseases;Visual evoked cortical potential;Woman

PROJECT_TITLE: The longer-term impact of prenatal exposure to SARS-CoV-2 infection and the COVID-19 vaccine on behavior, cognition, and brain functioning in the child

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: ES

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: Project Narrative Cardiovascular disease is the leading cause of death worldwide and exposure to environmental chemicals including plastic-associated chemicals has been associated with an increased risk of cardiovascular disease. This proposal will study how exposure to environmental chemicals increases atherosclerosis in the adults and their offspring. Results from the proposed studies will establish a novel therapeutic target for chemical-induced cardiovascular disease and will also have the potential to revolutionize our understanding of the etiology of many chronic human diseases originating from chemical-elicited intergenerational effects.

PI_NAMEs: ZHOU, CHANGCHENG  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Adult;Affect;Agonist;Atherosclerosis;bisphenol A;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cause of Death;Cells;Ceramides;chemical association;Chemical Exposure;Chemicals;Chronic;Citrates;Code;consumer product;Development;Dimensions;Disease;Dyslipidemias;Endocrine Disruptors;Environment;environmental chemical;Environmental Health;Equus caballus;Etiology;experience;Exposure to;Funding;Genes;Health;health assessment;Homeostasis;Human;human disease;Individual;innovation;interest;intergenerational;Laboratories;Ligands;Link;Lipids;Longitudinal Studies;Mediating;Molecular Biology;Morbidity - disease rate;mortality;mouse model;National Institute of Environmental Health Sciences;new therapeutic target;novel;offspring;Paternal Exposure;Pharmacology;phthalates;Plastics;Positioning Attribute;pregnane X receptor;programs;Receptor Signaling;Regulation;Research;Risk Assessment;RNA;Role;sensor;sperm cell;tool;Toxicology;Training;Xenobiotics

PROJECT_TITLE: Role of PXR in EDC-induced cardiovascular disease


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Primary Health Care;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: NEW CASTLE

ORG_NAME: CONTINUEYOU, LLC

ORG_STATE: ME

PHR: NARRITIVE STATEMENT Digital inequities, or the differential use of digital solutions based on demographic and socioeconomic status, limit the promise of mHealth and further divide the US population in terms of access and outcomes. The current proposal with develop RAE cHealth, a digital platform to facilitate peer-based recovery models into substance use disorder treatment programs, tailored to patients who are socioeconomically disadvantaged. The ultimate goal of RAE cHealth is to leverage a user-friendly interface to identify barriers to technology engagement and recovery, connect users with their peer recovery coach and other critical support systems, and empower users to be self-sufficient drivers of their own recovery.

PI_NAMEs: CARREIRO, STEPHANIE P;REINHARDT, MEGAN ROIS (contact)

PROGRAM_OFFICER_NAME: ANGELONE, LEONARDO MARIA

PROJECT_TERMS: addiction;Address;Affect;algorithm development;Algorithms;Characteristics;Clinical;clinical practice;cloud based;cohort;collaborative care;Collection;commercialization;Communication;Communities;Computer software;COVID-19 pandemic;craving;Data;data acquisition;Data Analyses;design;Detection;detection platform;Development;digital;digital divide;digital health;digital healthcare;digital intervention;digital platform;digital solutions;Disease;Disparity;Economically Deprived Population;Economics;Employment;empowerment;Fast Healthcare Interoperability Resources;Feedback;General Population;Goals;Health;Health equity research;Healthcare;Human Resources;improved outcome;Individual;Industry Standard;Inequity;innovation;Intervention;Interview;Legal patent;Machine Learning;Marketing;Medical Informatics;Medical Technology;Medicine;mHealth;mobile application;Modeling;Needs Assessment;Outcome;outreach program;pandemic disease;Patients;peer;peer recovery;peer support;Phase;Physiological;pilot test;Population;Prediction of Response to Therapy;programs;prototype;psychosocial;Recovery;recovery services;Recovery Support;Research Personnel;Research Project Grants;Research Project Summaries;Resources;Running;Secure;sensor;Services;Small Business Innovation Research Grant;smartphone application;social culture;social health determinants;Social support;sociocultural determinant;socioeconomic disadvantage;Socioeconomic Status;Stress;Structure;substance use;Substance Use Disorder;Support System;support tools;System;Target Populations;Technology;telehealth;Time;tool;treatment program;treatment services;United States National Institutes of Health;uptake;usability;user-friendly;Visualization;Visualization software;waiver;wearable sensor technology;Work

PROJECT_TITLE: RAE cHealth:  A digital community support tool to promote recovery from substance use disorder


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Patients with disorders in arousal, such as post-traumatic stress disorder (PTSD), are particularly susceptible to developing alcohol use disorders (AUD). In this application, I will study the novel role of astrocyte-neuron networks in the prefrontal cortex and their modulation by arousal-induced noradrenergic release while mice actively drink alcohol. These longitudinal studies of the relationship between astrocyte-neuron dynamics and arousal during alcohol consumption will provide important information on arousal disorders, such as PTSD and AUD, and may provide clinical hallmarks or therapeutic avenues for the treatment of these disorders.

PI_NAMEs: SIPE, GRAYSON OREN (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Ablation;Adrenergic Receptor;Affect;alcohol behavior;Alcohol consumption;alcohol use disorder;Alcohols;Anatomy;Animals;antagonist;Anxiety;anxiety symptoms;Arousal;Astrocytes;Axon;Behavior;Brain;Calcium;career;Cells;Clinical;Clinical Trials;Cognitive Science;Color;Communities;comorbidity;Consumption;Development;Diagnosis;Diameter;Disease;drinking;drinking behavior;Drug Targeting;Ethanol;Event;experimental study;extracellular;Fellowship;Female;Functional disorder;Future;Genetic;genetic manipulation;Goals;Grant;Head;Human;Hyperactivity;Image;in vivo;in vivo two-photon imaging;information processing;inhibitory neuron;insight;Lead;Locomotion;Longitudinal Studies;male;Measures;Mediating;Mentors;Methods;Modeling;Mus;neural;neuronal circuitry;Neurons;neurophysiology;neuroregulation;noradrenergic;Norepinephrine;Norepinephrine Receptors;novel;Optics;optogenetics;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Physiology;Post-Traumatic Stress Disorders;Postdoctoral Fellow;Predisposition;Prefrontal Cortex;Process;programs;Property;Pupil;Research;Research Infrastructure;response;Rewards;Role;sensor;Sex Differences;Signal Transduction;Stress;Structure;Substance abuse problem;Techniques;Testing;Therapeutic;Therapeutic Effect;Titrations;Training;two photon microscopy;two-photon;Wakefulness;Work

PROJECT_TITLE: Arousal-induced noradrenergic signaling modulates cortical astrocyte-neuron circuits during ethanol consumption

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Neural circuits determine our ability to locate and identify the objects that give rise to a visual scene. The breakdown of this ability can be observed in a number of neurological syndromes including visual agnosia. Studying how specific circuits and cell types contribute to normal visual perception will inform efforts to develop better diagnostic and therapeutic approaches for these disorders.

PI_NAMEs: FRANKEN, TOM P. (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Area;area V2;area V4;awake;B-Lymphocytes;Biological;Brain;Calcium;career;career development;cell type;Cells;Characteristics;Cues;Data;design;Development Plans;Diagnostic;diagnostic tool;Disease;Disparity;Distal;Electrodes;Electrophysiology (science);Endowment;Etiology;excitatory neuron;Exhibits;Face;Faculty;falls;Feedback;fluorophore;Functional disorder;Genetic;Goals;Grouping;Illusions;Image;inhibitory neuron;Interneurons;Lentivirus;Link;Macaca;Macaca mulatta;Maps;Mediating;Memory;Mentors;neural;neural circuit;Neurologic;Neurons;neurophysiology;Neurophysiology - biologic function;neurotransmission;nonhuman primate;Optics;orientation selectivity;Ownership;Perception;preference;Primates;Probability;Property;Reading;receptive field;Recording of previous events;Research;Research Personnel;Resolution;response;Role;sample fixation;Scientist;Side;Signal Transduction;Stimulus;Surface;Syndrome;System;Techniques;Testing;Tetanus Helper Peptide;Therapeutic;Time;Training;two-photon;Viral;Vision Disparity;Visual;Visual Agnosias;Visual Cortex;visual neuroscience;Visual Perception;visual processing;Work

PROJECT_TITLE: Border ownership and grouping in primate visual cortex


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Dietary Supplements

ORG_CITY: BOONE

ORG_DEPT: CHEMISTRY

ORG_NAME: APPALACHIAN STATE UNIVERSITY

ORG_STATE: NC

PHR: The human cytochrome P450 enzymes P450 27A1, 27B1, and 27C1 are involved in the metabolism of endogenous hormones and vitamins. There is little known about the structures of these enzymes and how these structures change during the reactions the enzymes catalyze, making it difficult to develop clinical therapies that alter the activity of these enzymes. This research project seeks to enable the design of new and safer therapies for various diseases effected by hormone or vitamin levels by providing a more thorough description of how the structure of these enzymes affects their function.

PI_NAMEs: REDDISH, MICHAEL JERRELL (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Adrenodoxin;Affect;biomedical scientist;bone health;Carcinogens;Cholesterol;Clinical;Cytochrome P450;Cytochromes;design;Development;Disease;enzyme activity;enzyme structure;Enzymes;Family;family structure;Fat-Soluble Vitamin;Goals;Health;hormone regulation;Hormones;Human;improved;inhibitor;interest;Laboratories;Laboratory Personnel;Lipids;lipophilicity;Malignant Neoplasms;Medicine;Membrane;Metabolism;Mixed Function Oxygenases;Neutrons;next generation;novel strategies;novel therapeutics;oxidation;Oxidation-Reduction;Pharmacologic Substance;Pharmacotherapy;prevent;Proteins;Reaction;Research Project Grants;Research Training;Retinoids;Roentgen Rays;steroid hormone metabolism;Structure;Structure-Activity Relationship;Testing;Training;undergraduate research;Vision;Vitamin D;Vitamins;X-Ray Crystallography

PROJECT_TITLE: Structure-Function Studies of the Human Cytochrome P450 27 Family

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-B(55)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: OVERALL: PUBLIC HEALTH RELEVANCE - NARRATIVE Child maltreatment is a public health crisis impacting more than 12% of US children. Unfortunately, this crisis has not fully benefitted from evidence-driven legislative action that is geared toward prevention and intervention to the same extent as other serious public health issues (e.g., smoking, obesity). Phase 2 of the Translational Center for Child Maltreatment Studies (TCCMS) will continue to conduct high-quality, high-impact science; translate and package this science into messages that resonate with community providers, policy makers and the general public; and traverse the Research-to-Policy Bridge by communicating these packages to legislative leaders. The TCCMS will continue to be a key national resource for conducting and rapidly disseminating impactful new science that can change health and development trajectories for survivors, mobilize public investment in child maltreatment prevention and treatment, accelerate science to practice, spark dynamic system-wide solutions, and support and inspire future generations to do the same.

PI_NAMEs: CONNELL, CHRISTIAN M (contact);JACKSON, YO

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: abuse neglect;Acceleration;Address;Age;aged;base;Behavior;Behavioral;Behavioral Mechanisms;Biological;biopsychosocial;Caring;Child;Child Abuse and Neglect;Child Advocacy;Child Development;child neglect;child protective service;Chronic;Clinical Trials;Collaborations;Communication;Communities;community based research;community engaged research;County;Creativeness;Criminal Justice;Data;design;Development;Disparity;disparity reduction;dynamic system;Economic Burden;Education;Evaluation;evidence base;experience;Forensic Medicine;Future Generations;General Population;Health;health disparity;Health Services Accessibility;high risk;Homelessness;Hospitals;Infant Mortality;Infrastructure;innovation;Institute of Medicine (U.S.);Institution;intergenerational;Intervention;Investigation;Investments;Knowledge;Leadership;Longitudinal cohort study;Mental disorders;minority children;Modeling;mortality;neurobiological mechanism;next generation;novel;Nurses;Obesity;observational cohort study;Outcome;outreach;Pathway interactions;Phase;phase 1 study;physical abuse;Policies;Policy Maker;Prevention;Primary Prevention;prospective;Prospective, cohort study;Provider;psychosocial;Public Health;public health relevance;racial disparity;racial minority;Reaction;Reporting;Research;resilience factor;Resources;Rural;Rural Community;scaffold;Science;Scientist;Services;Sexual abuse;Smoking;success;Survivors;System;Teenagers;telehealth;tool;Training;training opportunity;transition to adulthood;Translating;translational impact;Translational Research;Translations;transmission process;Trauma;underserved community;Universities;Work;Youth

PROJECT_TITLE: Penn State University's Translational Center for Child Maltreatment Studies (TCCMS)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences

PHR: Project Narrative  Transcranial magnetic stimulation (TMS) is increasingly being applied to effectively treat mental illness, however efforts to quantify the effects of TMS on the network architecture of the brain have largely been limited in scope and tied to specific neurologic and psychiatric disorders. The objective of the current work is to build and validate a whole-brain, domain-general model of brain connectivity changes following TMS, based on physical models of the current distribution at the cortex. PUBLIC HEALTH RELEVANCE: This work is relevant to public health because it will provide direct evidence that brain connectivity changes following neuromodulatory TMS vary as a function of the current density at the cortex, which can be used to predict psychiatric symptom change following neuromodulatory TMS.

PI_NAMEs: BALDERSTON, NICHOLAS LEE (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Address;Agreement;Brain;Clinical Trials;cohort;Data;density;depressed patient;Development;Disease;dosage;Dose;electric field;FDA approved;Functional Magnetic Resonance Imaging;Funding;Grant;healthy volunteer;Hour;Impairment;improved;innovation;interest;Investigation;Left;Literature;Long-Term Depression;Long-Term Potentiation;Measures;Mediating;Mental Depression;Mental disorders;Modeling;multidisciplinary;Nature;Nervous System Disorder;network architecture;neuroimaging;neuroregulation;novel;Obsessive-Compulsive Disorder;Outcome Measure;Pattern;Performance;physical model;Physiologic pulse;Population;Prediction of Response to Therapy;primary outcome;psychiatric symptom;Public Health;public health relevance;Publishing;Reaction Time;Research Personnel;Rest;Short-Term Memory;smoking cessation;Statistical Models;success;symptomatic improvement;Synapses;Synaptic plasticity;Techniques;Transcranial magnetic stimulation;Treatment outcome;United States National Institutes of Health;Work

PROJECT_TITLE: Novel electric-field modelling approach to quantify changes in resting state functional connectivity following theta burst stimulation


NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Pediatric;Prevention;Social Determinants of Health;Violence Research

PI_NAMEs: NOLL, JENNIE G (contact)

PROJECT_TERMS: Acceleration;Administrative Efficiency;Adolescent;Articulation;Child;Child Abuse and Neglect;Child Sexual Abuse;Child Welfare;Clinical;Collaborations;Communication;Complex;Data;Data Security;design;Doctor of Philosophy;Effectiveness;Ensure;Environment;evidence base;experience;Exposure to;Faculty;forging;Foundations;Funding;Grant;Infrastructure;innovation;Institution;interdisciplinary collaboration;Internships;Leadership;Maryland;Mentors;Methodology;Modeling;National Institute of Child Health and Human Development;next generation;novel strategies;Outcome;parenting intervention;Parents;pediatrician;Peer Review;Phase;Physicians;Policies;Policy Making;Postdoctoral Fellow;prevent;Prevention;Prevention program;Primary Prevention;Productivity;Progress Reports;recruit;Research;Research Personnel;research study;Resources;scaffold;Science;Scientist;Secure;Societies;success;System;teacher;tool;Training;training opportunity;Translations;undergraduate student;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: ADMINISTRATIVE CORE: Penn State University's Translational Center for Child Maltreatment Studies (TCCMS)


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Infectious Diseases;Nutrition;Obesity;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE HIV treatment programs throughout sub-Saharan Africa are adopting dolutegravir (DTG)-based regimens as first-line antiretroviral therapy (ART) despite early evidence that this agent is associated with excess weight gain. In this proposal, I will evaluate the behavioral correlates of weight change and glucose intolerance associated with DTG-based ART, apply these findings in developing contextually appropriate interventions to prevent weight gain and diabetes in people with HIV (PWH) and then assess these interventions in a factorial- randomized feasibility pilot study. This research is of high public health relevance given the widespread use of DTG globally, including up to 20 million PWH in sub-Saharan Africa, the background obesity epidemic in the region and the excellent platform offered by HIV treatment programs, through which interventions to prevent obesity can be delivered.

PI_NAMEs: MANNE-GOEHLER, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Acceleration;acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adopted;Africa;Africa South of the Sahara;Anthropometry;antiretroviral therapy;Area;arm;Behavioral;Behavioral Model;Body Weight Changes;Cardiovascular system;care systems;career;Caring;Chronic;Chronic Disease;Clinical;clinical trial analysis;Clinical Trials;cohort;Collaborations;Communicable Diseases;Conduct Clinical Trials;Data;Data Analyses;data integration;Demographic and Health Surveys;design;Diabetes Mellitus;Diabetes prevention;diabetes risk;Dietary Practices;Disease;Educational Status;efficacy testing;Epidemic;Epidemiologic Methods;Epidemiology;excessive weight gain;experience;fast food;Feasibility Studies;feasibility testing;Feedback;Foundations;Funding;General Hospitals;global health;Glucose Intolerance;glucose tolerance;Glycosylated hemoglobin A;glycosylated serum albumin;Goals;Health;Health system;HIV;Home;improved;increased appetite;Intake;International;Intervention;Intervention Studies;Intervention Trial;Interview;Lead;low and middle-income countries;Massachusetts;Measures;Medicine;men;Mentors;Mentorship;Metabolic;Metabolic Diseases;Morbidity - disease rate;mortality;multidisciplinary;nutrition;Obesity;Obesity Epidemic;obesity prevention;observational cohort study;Observational Study;Overweight;Paper;Persons;Pharmaceutical Preparations;pharmacologic;Physical activity;Physicians;Pilot Projects;Population;Positioning Attribute;prevent;Preventive;prospective;prototype;Public Health;public health relevance;Publications;Publishing;Randomized;Regimen;Reporting;Research;Research Institute;Research Priority;Risk Factors;Scientist;skill acquisition;skills;South Africa;standard of care;sugar;sweetened beverage;Testing;therapy design;therapy development;Time;Training;treatment as usual;Treatment Efficacy;treatment program;Trust;United States National Institutes of Health;Weight;Weight Gain;Woman

PROJECT_TITLE: Preventing Weight Gain and Diabetes in People with HIV in South Africa

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Pediatric;Social Determinants of Health;Violence Research

PI_NAMEs: JACKSON, YO  (contact)

PROJECT_TERMS: Awareness;Child Abuse and Neglect;Child Welfare;Clinical;Communication;Communities;Data;data management;design;digital;digital media;Distal;Electronic Mail;Ensure;Environment;evidence base;experience;Generations;Goals;Hand;Human Resources;improved;Infrastructure;innovation;Institution;Knowledge;member;Modernization;news;Newsletter;Policies;Policy Maker;Positioning Attribute;Research;Research Methodology;Research Personnel;Research Support;Resource Sharing;Resources;Science;scientific hub;Social Interaction;social learning;social media;Source;Specific qualifier value;Students;System;tool;Training;Translating;translational scientist;Translations;Universities;Update;web site;Work

PROJECT_TITLE: RESOURCE CORE:  Penn State University's Translational Center for Child Maltreatment Studies (TCCMS)


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Brain Disorders;Endocrine Disruptors;Estrogen;Genetics;Human Genome;Neurosciences

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE All humans are exposed to environmental endocrine-disrupting chemicals (EDCs) from industry, agriculture, and plastics. Experimental animal studies and epidemiological data in humans show that EDC exposures during hormone-sensitive periods early in life can change how the brain develops, and at the same time, affect future generations through actions on the germline (precursors to sperm and eggs). By identifying the molecular mechanisms by which developmental EDC exposures cause epigenetic changes in exposed individuals and their descendants, the proposed work has the potential to inform interventions for exposed humans and their offspring.

PI_NAMEs: GORE, ANDREA C (contact)

PROJECT_TERMS: Address;Affect;Agriculture;Animal Experiments;Area;bioinformatics pipeline;Brain;brain cell;cell type;Cells;Chemical Exposure;Chemical Industry;Chemicals;Data;Development;Disease;DNA;dosage;egg;Endocrine;Endocrine Disruptors;epidemiologic data;Epigenetic Process;epigenomics;exposed human population;Exposure to;Female;Fetus;flexibility;Functional disorder;Future Generations;Generations;Germ Cells;Germ Lines;Health;Heritability;Heterogeneity;Hormones;Human;Individual;intergenerational;Intervention;Knowledge;Lead;Life;Link;male;Modeling;Modification;Molecular;multiple omics;neurobehavioral;neurobehavioral disorder;Neurobiology;offspring;Outcome;Phenotype;Plastics;programs;Qualifying;Rattus;reproductive;Research;RNA;Route;Security;sex;Sex Differences;Somatic Cell;sperm cell;targeted treatment;Time;Tissues;transmission process;Untranslated RNA;Work

PROJECT_TITLE: Environmental Epigenetics of EDCs: From Germline to Brain


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: Newark

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE This application addresses the critical challenge of uptake, retention and equity in medications for opioid use disorder among adults with disabilities, assessing the factors associated with treatment patterns; impact on clinical outcomes including overdoses; and strategies for reducing disparities. We will utilize national Medicare data for 2008-2025 linked with the National Death Index, Medicaid claims, formulary policies, and other data sources to assess how policy, community, provider and patient factors interact to shape MOUD initiation and retention, and in turn overdose and other clinical outcomes, including differential uptake and outcomes associated with Medicare policy changes affecting tele-health reimbursement and formulary policies for MOUD. Results of this innovative and comprehensive assessment of the multi-level factors shaping MOUD uptake and outcomes among MDBs will have important implications for policy and practice across payers and health care systems.

PI_NAMEs: CRYSTAL, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: access disparities;Accounting;Address;Adult;Affect;American;beneficiary;Black race;Caring;Cessation of life;Characteristics;Clinical;cohort;Communities;comorbidity;Complex;Data;Data Sources;Diagnosis;disability;Disabled Persons;Disparity;disparity reduction;dissemination strategy;Distant;dosage;Drug Prescriptions;drug testing;Enrollment;Environment;Equity;Ethnic Origin;Event;Excision;experience;experimental study;Failure;Fentanyl;Formularies;Gender;Harm Reduction;Healthcare Systems;high risk;Hispanic;Hospitalization;improved;indexing;Individual;innovation;insight;Intervention;Link;longitudinal analysis;Low income;male;Measures;Medicaid;Medical;Medicare;medication for opioid use disorder;Mental Health;Minority;minority patient;Modality;mortality;multiple chronic conditions;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid use disorder;Outcome;Overdose;overdose death;Overdose reduction;overdose risk;Pain;patient subsets;Patients;Pattern;Peer Review;Penetration;Persons;Policies;Policy Developments;policy implication;poor communities;Population;prescription opioid;Prevalence;prior authorization;Provider;provider networks;psychosocial;Publications;Race;racial minority;residence;Resources;Risk;Risk Reduction;Role;Shapes;social vulnerability;Subgroup;success;Suicide;Survivors;System;telehealth;Time;tool;Translations;treatment and outcome;treatment disparity;treatment duration;Treatment outcome;treatment pattern;trend;Uninsured;Update;uptake;Urine;Variant

PROJECT_TITLE: Improving MOUD Access, Opioid-Related Outcomes and Equity Among Medicare Beneficiaries with Disability


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence

PI_NAMEs: SCHREIER, HANNAH MILENA CAROLINE (contact)

PROJECT_TERMS: Academic achievement;Adolescence;Age;aged;aging related disease;American;Attention;base;Behavioral;behavioral health;Biological;Biological Sciences;Blood;Brain;career preparation;Caregivers;Cell Aging;Characteristics;Child;Child Abuse and Neglect;Child Health;child protective service;Child Welfare;Childhood;Chronic;Chronic Disease;Cognitive;cohort;contextual factors;Data;design;Development;early life adversity;Economic Burden;Emotional;Enrollment;Epigenetic Process;ethnic identity;ethnic minority;Ethnic Origin;experience;Exposure to;Female;Future;Gender;Genotype;Goals;Grant;Health;health determinants;high risk;Immunologics;improved;Interdisciplinary Study;intersectionality;Intervention;Investigation;Knowledge;late life;Life;Life Cycle Stages;Life Experience;life span;Literature;Longitudinal cohort study;male;Measurement;Mediating;Medical;Methods;minority children;Modeling;Molecular;Morbidity - disease rate;mortality;MRI Scans;neglect;Neighborhoods;Neuronal Plasticity;Neurosecretory Systems;Outcome;Pathway interactions;person centered;Personal Satisfaction;Phase;physical abuse;physical conditioning;Physiological;Population;Positioning Attribute;Prevention;Process;prospective;Prospective cohort;psychologic;psychosocial;Psychosocial Factor;pubertal timing;Publishing;Race;racial minority;Reaction;Recording of previous events;Records;Recovery;Reporting;Reproducibility;Research;resilience;Resources;Risk;Risk Reduction;Role;rural area;Sampling;Science;Services;Severities;Sexual abuse;social capital;Stress;stressor;success;Survivors;System;Testing;Time;Tissues;transition to adulthood;Universities;urban area;Validation;Variant;Visit;Vulnerable Populations;Youth

PROJECT_TITLE: PROJECT 1:  Penn State University's Translational Center for Child Maltreatment Studies (TCCMS)


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative/Public Health Relevance The newly emerging areas of stem cell biology, cell based therapies, gene therapy, cellular immunology, recombinant cytokines, and improving the safety and efficacy of transfused blood components have potential for the improvement of transfusion practices and the management of hematologic diseases. Thus, it is critical to train the next generation of investigators who can conduct basic, translational, and clinical research in Immunohematology and Transfusion Medicine. This proposed program renewal, with a 20 year successful history, aims to accomplish these goals.

PI_NAMEs: HENDRICKSON, JEANNE E;KRAUSE, DIANE S;SMITH, BRIAN RICHARD (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TITLE: Immunohematology/Transfusion Medicine Research Training

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Physical Injury - Accidents and Adverse Effects;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth;Violence Against Women;Violence Research;Women's Health Research

PI_NAMEs: MIYAMOTO, SHERIDAN  (contact)

PROJECT_TERMS: Address;Adolescent;adolescent health;Advocacy;aged;assault;Automobile Driving;Blinded;Caring;Child Abuse and Neglect;Collection;Communities;comorbidity;Consultations;coping;cost;Cost-Benefit Analysis;Costs and Benefits;Criminal Justice;Data;Decision Making;design;Development;Disparate;Disparity;disparity reduction;Documentation;Effectiveness;Elements;Ensure;Environment;Equity;Evaluation;evidence base;experience;Feeling hopeless;Forensic Medicine;Geography;healing;Health;health care service utilization;Health Technology;Healthcare;Hospitals;implementation design;improved;Individual;infection risk;Injury;instrument;Interview;Investigation;Justice;Lawyers;Medical Records;Mental Health;Mental Health Services;Mentors;Mission;Modeling;novel;Nurses;Outcome;Outcome Study;Patients;Personal Satisfaction;physical conditioning;Policies;post implementation;Post-Traumatic Stress Disorders;Pregnancy;Process;program costs;Program Sustainability;programs;prospective;Provider;psychologic;quality assurance;Quality of Care;Recovery;Research Design;Resolution;response;Risk Taking;Rural;Rural Community;Schools;service utilization;Services;Sexual abuse;sexual assault;Site;skills;Societies;Specialist;success;Survivors;Technology;telehealth;telehealth systems;Testing;Time;Training;transition to adulthood;Trauma;treatment as usual;underserved community;Universities;Victimization;Vulnerable Populations;Work;Writing

PROJECT_TITLE: PROJECT 2: Penn State University's Translational Center for Child Maltreatment Studies (TCCMS)


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Dissemination and Implementation Research;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE The goal of this Specialized Innovation Program is to identify and overcome barriers that impede the translational science of rapid genomic medicine discoveries at the point of care by assembling the infrastructure, technology, and strategies to design and develop a rapid genomic diagnostic platform, using the newborn intensive care unit as our laboratory. We will design and develop an innovative, collaborative, patient- focused, and electronic health record-interfaced translational platform that efficiently integrates rapid genomic medicine at the point of care.

PI_NAMEs: ESTABROOKS, PAUL ;TRISTANI-FIROUZI, MARTIN  (contact)

PROGRAM_OFFICER_NAME: GANNOT, GALLYA

PROJECT_TERMS: Acceleration;Adoption;Area;bioinformatics tool;Clinical;clinical care;clinical implementation;clinical phenotype;Clinical Sciences;Complex;Computer software;Data;design;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic platform;diagnostic tool;Dissemination and Implementation;dissemination science;electronic health information;Electronic Health Record;electronic health record system;Emerging Technologies;empowerment;Explosion;Faculty;Fostering;Foundations;Genetic;Genetic Variation;Genome;genome sciences;genome sequencing;genomic data;Genomic medicine;genomic variation;Genomics;Goals;Guidelines;implementation science;improved;Industry;Infrastructure;innovation;Intensive Care Units;interoperability;Intuition;Investments;Laboratories;Life;Methods;National Center for Advancing Translational Sciences;Neonatal Intensive Care Units;novel;open source;Patient Care;Patients;personalized care;point of care;portability;precision medicine;Process;programs;rare mendelian disorder;Recording of previous events;Research;Science;success;Technology;tool;translational genomics;Translational Research;United States National Institutes of Health;Universities;Utah;Variant;Visualization;whole genome

PROJECT_TITLE: CTSA RC2 Program at University of Utah: A Translational Platform for Rapid Genomic Medicine


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE This application meets an urgent national need and seeks continued funding to train PhD students to understand and use animal models to study human infectious diseases. Research conducted by these trainees will have broad impact on the understanding, treatment, and prevention of infectious diseases, which are among the most important causes of human illness.

PI_NAMEs: MCSORLEY, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Animal Model;infectious disease model;Training Programs

PROJECT_TITLE: Animal Models of Infectious Diseases Training Program

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Health Services;Pediatric;Prevention;Social Determinants of Health;Violence Research

PI_NAMEs: CONNELL, CHRISTIAN M (contact)

PROJECT_TERMS: Academy;acronyms;Address;Administrator;Affect;American;Applied Research;Area;career;Caregivers;Child;Child Abuse and Neglect;Child Advocacy;child protection;child protective service;Collaborations;Communities;community based research;community partners;Community Practice;Consensus;Consult;Data;Data Analyses;Data Collection;design;Detection;Development;direct application;Education;Educational workshop;Effectiveness;Event;Evidence based practice;experience;Face;Fatality rate;Fellowship;Funding;Future;graduate student;Growth;Health;Impact evaluation;improved;Infrastructure;innovation;Institution;Investments;Leadership;Life Cycle Stages;Lived experience;Methodology;Minor;Modeling;National Institute of Child Health and Human Development;Nature;outreach;Parents;Pattern;Pediatrics;perpetrators;Policies;Policy Analysis;Policy Maker;Population;pressure;prevent;Prevention;Privatization;Process;racial disparity;Rehabilitation therapy;Research;Research Personnel;Research Priority;Research Project Grants;research study;research to practice;Resources;response;Risk;Science;service intervention;Services;Social outcome;student training;Surveys;System;Testing;Time;Training;Translating;Translational Research;undergraduate student;Universities;Variant;webinar;Work;Youth

PROJECT_TITLE: DISSEMINATION AND OUTREACH CORE:  Penn State University's Translational Center for Child Maltreatment Studies (TCCMS)


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Cardiovascular;Heart Disease

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PI_NAMEs: ABE, JUN-ICHI  (contact)

PROGRAM_OFFICER_NAME: VEDAMONY, MERRILINE M

PROJECT_TERMS: Cardiovascular Diseases;Premature aging syndrome;radiation mitigation

PROJECT_TITLE: Mitigating radiation-induced cardiovascular disease by inhibiting premature aging


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Frontotemporal dementia (FTD) is a leading cause of early-onset dementia, and loss-of-function mutations in progranulin (GRN) are one of three main genetic causes. Patients with FTD-GRN have activity deficits of neuronal β-glucocerebrosidase (GCase), a lysosomal enzyme implicated in Parkinson disease and Gaucher disease. This proposal seeks to determine if progranulin facilitates GCase trafficking and if loss of GCase activity contributes to lysosomal and behavioral abnormalities caused by progranulin deficiency.

PI_NAMEs: BOYLE, NICHOLAS RYAN (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Address;Behavior;Behavioral;Binding;Biological Assay;Brain;carcinogenicity;Clinical Trials;Competence;Data;Dementia;design;Development;Disease;early onset;Enzymes;Exhibits;experience;Experimental Designs;experimental study;Frontotemporal Dementia;Functional disorder;Gaucher Disease;gene therapy;Genetic;genetic risk factor;glucosylceramidase;Glycoproteins;glycosylation;Golgi Apparatus;granulin;granulin 2;granulin 4;Growth Factor;Immunomodulators;Impairment;improved;Incidence;Individual;insight;Length;loss of function;loss of function mutation;Loss of Heterozygosity;Lysosomal Storage Diseases;Lysosomes;Measures;Mediating;Molecular Chaperones;Mus;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Ceroid-Lipofuscinosis;Neurons;neurotoxic;novel;overexpression;Parkinson Disease;Parkinsonian Disorders;Patients;Pattern;PGRN gene;Physiologic pulse;pre-clinical;prevent;Proteins;Reporting;Research Project Grants;Rewards;Role;Safety;skills;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Uses;trafficking;Translational Research;Work

PROJECT_TITLE: The cause and effect of reduced ÃÂ²-glucocerebrosidase activity in the setting of progranulin deficiency


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative: Small molecule based drugs continue to be a vital avenue for treating human disease. Requiring a chemical landscape that is persistently increasing in complexity, the discovery and development of these pharmaceuticals necessitates continued innovation in the synthetic chemistry involved in their construction if we are to solve outstanding problems in human health. The proposed work will develop new methods for the selective synthesis of a range of nitrogen-containing compounds, especially amines, streamlining and improving routes while also providing access to new chemical landscapes that are comprised of these medicinally proven scaffolds.

PI_NAMEs: MALCOLMSON, STEVEN JOSEPH (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Alkylation;Amines;Area;Catalysis;catalyst;Chemicals;Complex;Coupling;cycloaddition;Development;drug discovery;functional group;Goals;Health;Human;human disease;Hydrogen;Imines;improved;innovation;invention;Laboratories;Medicine;Methods;Nitrogen;novel;Organic Synthesis;Oxides;Pharmaceutical Preparations;Pharmacologic Substance;Preparation;Process;pyridine;quinoline;Reaction;Reagent;Route;scaffold;small molecule;Synthesis Chemistry;United States National Institutes of Health;Work

PROJECT_TITLE: Strategies for the Catalytic Synthesis of Nitrogen-Containing Molecules


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Chronic Pain;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pain Research;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: GALVESTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: RELEVANCE TO PUBLIC HEALTH Pain is a major public health problem that is common among older adults, especially women, yet women’s pain is frequently underdiagnosed and undertreated. Untreated pain is a potentially modifiable risk factor that may contribute to the gender disparity in Alzheimer’s disease and related dementias (ADRD). Better understanding of these gender disparities is critical to improving the health of older adults, especially as women live longer than men and make up a larger proportion of older adults with ADRD.

PI_NAMEs: MILANI, SADAF AREFI (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Acceleration;Address;Age;Aging;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Applications Grants;Area;care outcomes;career;Characteristics;chronic pain;chronic pain management;Clinical;Clinical Data;Competence;Complex;Data;Data Reporting;Dementia;dementia burden;Diagnosis;Disparity;Disparity in diagnosis;Epidemiology;Ethnic Origin;experience;Extramural Activities;Funding;Gender;gender difference;gender disparity;Geriatrics;Goals;Health;Health and Retirement Study;Health behavior;health data;health disparity;Health Personnel;Health system;High Prevalence;improved;Individual;Inequality;Internal Medicine;Intervention;Knowledge;late life;Leadership;Learning;Life Cycle Stages;Life Expectancy;Link;Longitudinal Studies;Manuscripts;Medical;Medicare;Medicare claim;men;Mentors;modifiable risk;National Institute on Aging;novel;older adult;older women;Outcome;Pain;Pain management;Pain Measurement;Palliative Medicine;Pathogenesis;Pathology;Pathway interactions;Patient Self-Report;population based;Process;professor;programs;Provider;psychologic;Public Health;Race;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Risk Factors;Role;self diagnosis;sex;Sex Differences;skills;social;Social status;Socioeconomic Factors;Source;Statistical Methods;Surveys;System;Techniques;Texas;Training;Training Activity;treatment and outcome;treatment disparity;Universities;Woman;women versus men;women's diagnosis

PROJECT_TITLE: Gender Disparities in Pain and Treatment and their Association with Alzheimer's Disease and Related Dementias (ADRD)

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Tuberculosis (TB) is a globally significant threat to public health caused by Mycobacterium tuberculosis (Mtb) infection. Myeloid derived suppressor cells (MDSCs) are associated with increased disease severity and may contribute to TB pathogenesis but their functions at the site of disease and whether they can host Mtb remain to be elucidated. This project combines mechanistic and translational studies to investigate pathologic and potentially protective MDSC functions in TB to assess their suitability as targets for host-directed therapies.

PI_NAMEs: BRYSON, BRYAN DAVID;MATTILA, JOSHUA T. (contact);ROBINSON, CORY MICHAEL

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Acute;Address;Affect;Animals;Antimycobacterial Agents;Antitubercular Agents;Bacille Calmette-Guerin vaccination;Bacteria;Biological Assay;Cavia;Cell Communication;Cell Count;cell free DNA;Cell Physiology;cell type;Cells;Cellular biology;Competence;Data;design;Development;Disease;Disease Progression;Effectiveness;Effector Cell;experience;FDA approved;Flow Cytometry;fluorescence imaging;Functional disorder;Future;Gene Expression Profile;Genetic Transcription;Granuloma;high dimensionality;HIV/TB;Human;human model;Image Cytometry;Immune;immune function;Immune response;Immune System Diseases;Immunity;Immunosuppression;Impairment;improved;improved outcome;In Situ;Infection;Infiltration;Inflammation;inhibitor;innovation;interest;Intervention;Knowledge;Lesion;Link;Literature;Lung;Macaca;Macrophage;Mediating;Microbiology;Modeling;Molecular;molecular imaging;Mouse Strains;Mus;mycobacterial;Mycobacterium tuberculosis;Myeloid Cells;Myeloid-derived suppressor cells;Nitric Oxide;nonhuman primate;novel;Organ;Outcome;Pathogenesis;Pathogenicity;Pathologic;Patients;peripheral blood;permissiveness;Persons;PET/CT scan;Phagosomes;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Play;Positron-Emission Tomography;Predisposition;Property;Public Health;Publishing;Pulmonary Inflammation;recruit;Regimen;Reporter;Resistance;response;restraint;Role;safety assessment;Severities;Severity of illness;single-cell RNA sequencing;Site;small molecule;small molecule inhibitor;success;Supporting Cell;synergism;System;T cell response;T-Cell Activation;T-Lymphocyte;targeted agent;targeted treatment;Testing;Tissues;transcriptomics;translational study;Treatment Efficacy;Tuberculosis;tuberculosis drugs;tuberculosis immunity;tuberculosis treatment;Umbilical Cord Blood;vaccination against tuberculosis;Work;X-Ray Computed Tomography

PROJECT_TITLE: Elucidating the mechanisms and consequences of MDSC-regulated immunity in TB

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-B(02)]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Ulcerative colitis (UC), an aggressive inflammatory bowel disease in humans, is characterized by chronic inflammation of the colon. The role the gut microbiome plays in UC remains poorly understood. This proposal will expand an important study of microbiome proteases observed to be strongly associated with UC.

PI_NAMEs: GONZALEZ, DAVID J (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;Animals;Bacteria;bacterial genetics;Bacteroides;Basic Science;Biochemical;Blood;Cell Culture Techniques;Chronic;Chronic Disease;Clinical;cohort;Colitis;Collagen;Colon;Colonic inflammation;Coupled;Crohn's disease;data integration;Data Set;design;Development;Diagnosis;Disease;Disease Management;effective therapy;Epithelium;Feces;Functional disorder;Genetic;Genomics;Germ-Free;Goals;gut microbiome;gut microbiota;Histologic;host microbiome;host microbiota;Human;Immune response;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;Inflammatory;Inflammatory Bowel Diseases;inhibitor;Integration Host Factors;Interleukin-10;intestinal barrier;Intestinal permeability;Investigation;Link;Mediating;Metagenomics;metaproteomics;microbial;Microbiology;microbiome;microbiome research;microbiota;Modeling;Mucins;Mucositis;Mus;mutant;Nature;North America;novel;novel strategies;novel therapeutic intervention;Pathway interactions;Patients;Peptide Fragments;Peptide Hydrolases;Persons;Play;Prevalence;prevent;Protease Inhibitor;Proteins;Proteolysis;Publishing;Regulation;Role;Sampling;Serine Proteinase Inhibitors;Serum;Severities;Severity of illness;Shotguns;stool sample;Stress;Structure;Taxonomy;Testing;Therapeutic;Tight Junctions;tool;Translational Research;Transplantation;Ulcerative Colitis;Validation;Work

PROJECT_TITLE: Microbiome Driven Proteolysis as a Contributing Factor to Severity of Ulcerative Colitis Disease Activity

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Data Science;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Primary age-related tauopathy (PART) is a pathology commonly observed in the brains of aged individuals de- scribed by the presences neurofibrillary tangles (NFTs) and the in the absence of amyloid (Aβ) plaques. Here, we propose three independent approaches to understand the genetic, clinical, morphological, and transcriptomic architecture of PART to identify underlying mechanisms of tauopathy. The methods described here will bridge the current knowledge gap by providing an advanced understanding of the drivers of PART and distinguish disease pathogenesis and progression from normal aging.

PI_NAMEs: FARRELL, KURT WILLIAM (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: abeta deposition;Address;age related;Aging;aging population;Algorithms;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloidosis;Apoptosis;Architecture;Area;Artificial Intelligence;Autopsy;Back;Basic Science;beta amyloid pathology;Biomedical Engineering;Brain;Categories;cell type;Cells;Chromosome 4;Clinical;Cognitive;Computer Vision Systems;Computing Methodologies;Data;data integration;Dementia;Diagnosis;differential expression;Disease;Disease Progression;Elderly;Exhibits;experience;Genes;Genetic;genetic association;Genetic Markers;genome wide association study;genome-wide;Genomics;Goals;Grant;Human;Impaired cognition;Impairment;innovation;insight;interest;Knowledge;Machine Learning;machine learning classifier;machine learning model;Measurement;medial temporal lobe;Mediating;Mentors;Methods;Microtubules;mild cognitive impairment;Modeling;Molecular;molecular marker;Morphology;mRNA Expression;Nerve Degeneration;neural network;Neurofibrillary Tangles;Neuroglia;Neurons;neuropathology;neuroprotection;normal aging;novel;novel marker;Pathogenesis;Pathologic;Pathology;pathology imaging;Patients;Pattern;phenotypic data;Pick Disease of the Brain;Population;Positioning Attribute;Post-Translational Protein Processing;Proteins;proteostasis;Research;Research Personnel;risk variant;Scientist;Semantics;Senile Plaques;single cell analysis;single cell sequencing;single-cell RNA sequencing;Staging;Stains;supervised learning;tau Proteins;tau-1;Tauopathies;Techniques;Technology;Testing;Tissue Banks;Tissue Sample;Tissues;Training;trait;Transcription Alteration;transcriptome;transcriptome sequencing;transcriptomics;Up-Regulation;vector;whole slide imaging;Work

PROJECT_TITLE: Novel artificial intelligence-based approaches to understand the pathological and genetic drivers of primary tauopathies


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

PHR: PROJECT NARRATIVE Mitochondria provide the fuel for cellular activities, and are frequently damaged in cardiovascular disorders, due to becoming overloaded with calcium. The main pathway for calcium to enter the mitochondria is through a channel known as the mitochondrial calcium uniporter. In this proposal, we will examine whether regulation of this channel can be exploited for new therapies targeting calcium overload.

PI_NAMEs: CHAUDHURI, DIPAYAN  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Acute;Acute Disease;Affect;Affinity;Animal Model;Architecture;ATP Synthesis Pathway;Binding;Biological Assay;Biology;Body System;Calcium;Calcium Binding;Calcium Signaling;calcium uniporter;Cardiovascular Diseases;Cardiovascular system;Cell Death;Cells;Charge;Chemicals;Chronic;Chronic Disease;Clinical Pharmacology;clinical translation;Complex;Cryoelectron Microscopy;Cytoplasm;Dimerization;Disease;Drug Design;Electrophysiology (science);Failure;Functional disorder;Genetic;Goals;Group Structure;Heart;Heart failure;Heart Injuries;Homeostasis;Human;Impairment;improved;in vivo;inhibitor;Injury;innovation;Investigation;Ischemia;lipophilicity;Location;Mediating;Membrane;Mitochondria;Mitochondrial Matrix;Molecular;multimodality;Mutagenesis;Myocardial Infarction;N-terminal;new therapeutic target;novel;Pathologic;Pathway interactions;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;Physiological;Positioning Attribute;Predisposition;preservation;prevent;Principal Investigator;Proteins;Publications;Regulation;research study;skills;small molecule;stoichiometry;structural biology;Structure;Swelling;targeted treatment;Testing;tool;uptake;Vertebral column;voltage;Work

PROJECT_TITLE: Regulation of the mitochondrial calcium uniporter

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

PHR: Narrative The proposed study will investigate the role of focal adhesion kinase in cholesterol homeostasis in macrophage foam cells and could produce a new treatment option in atherosclerosis by reducing the foam cell formation via reduced cholesterol influx and elevated cholesterol efflux.

PI_NAMEs: LIM, STEVE  (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Actins;antiporter;Apolipoprotein E;Arterial Fatty Streak;Arteries;Atherosclerosis;ATP binding cassette transporter 1;Blood Vessels;Cardiovascular Diseases;Cause of Death;CD36 gene;cell motility;Cells;Cholesterol;Cholesterol Homeostasis;Complex;CSF1R gene;Data;Endocytosis;Equilibrium;Excision;filamin;Foam Cells;Focal Adhesion Kinase 1;Gene Expression;Genetic;Genetic Transcription;Homeostasis;Inflammation;insight;Integrins;Ischemic Stroke;Lipids;LXRalpha protein;Macrophage;Mediating;Modeling;Molecular;mortality;mouse model;Mus;Myocardial Infarction;Myocardial Ischemia;Nuclear;Nuclear Protein;Nuclear Translocation;oxidized low density lipoprotein;patient subsets;Patients;Peroxisome Proliferator-Activated Receptors;pharmacologic;Phosphotransferases;Population;prevent;Preventive;Proliferating;Protein Tyrosine Kinase;Regulation;Role;scavenger receptor;sensor;Signal Transduction;SMRT protein;targeted treatment;Therapeutic;uptake;western diet

PROJECT_TITLE: FAK regulation of cholesterol influx and efflux in foam cells

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE Efficient sensory processing relies on the development of precise connectivity and deficits in sensory processing are common in many neurodevelopmental disorders (NDDs). However, the mechanisms underlying circuit development and the etiology of sensory deficits in NDDs are poorly understood, precluding the development of effective therapies. In this proposal, we will use a combination of in vivo anatomic, electrophysiologic, and environmental modification techniques in transgenic and knockout mouse models to elucidate the mechanisms by which proper connectivity is established in the developing visual system and how these processes are disrupted in NDDs.

PI_NAMEs: TRIPLETT, JASON  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;anatomical tracing;Anatomy;Anxiety;area striata;Automobile Driving;Computer Models;Data;Development;effective therapy;Electrophysiology (science);environmental enrichment for laboratory animals;Etiology;experience;experimental study;Eye;Fragile X Syndrome;Functional disorder;Genetic;in silico;in vivo;insight;knockout gene;Knockout Mice;Knowledge;Maintenance;Maps;Mediating;Modeling;Modification;Molecular;mouse model;Mus;Neurodevelopmental Disorder;Neurons;novel;overexpression;Population;Process;programs;Retina;Retinal Ganglion Cells;Role;Sensory;sensory mechanism;social communication;Specificity;superior colliculus Corpora quadrigemina;Synapses;Techniques;Testing;therapeutic target;Transgenic Organisms;Vision;Visual;visual dysfunction;visual map;Visual System

PROJECT_TITLE: Mechanisms of Synaptic Specificity in Visual Circuits

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Emergency Care;Health Services;Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Serious Mental Illness;Substance Misuse;Suicide;Violence Research

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE Suicide and overdose are at record levels and continue to rise; opioid use disorders (OUD) and mental illness are major contributors to both. Emergency Departments (ED) are a key location in which to engage patients. This study will inform the development of an adaptive intervention that is optimally effective in increasing buprenorphine use for adults presenting to the ED with an OUD-related event.

PI_NAMEs: HERRING, ANDREW ;KALMIN, MARIAH ;WATKINS, KATHERINE E (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Accident and Emergency department;acute care;adaptive intervention;addiction;Address;Adult;Ambulatory Care;behavioral health;bridge program;Buprenorphine;California;Caring;Cessation of life;collaborative care;comorbidity;Data;Death Rate;Development;Disease;Dose;dual diagnosis;Emergency Care;Emergency department visit;Emergency treatment;Enrollment;Epidemic;Event;evidence base;Goals;Heterogeneity;High Prevalence;high risk;Hospitals;improved;Individual;innovation;Intervention;intervention delivery;Link;Location;Measures;medical complication;medication for opioid use disorder;Mental disorders;Mental Health;Modeling;mortality;mortality risk;National Institute of Drug Abuse;Nature;opioid overdose;opioid use;opioid use disorder;Outpatients;Overdose;overdose death;Overdose reduction;overdose risk;Patient Care;patient engagement;Patients;Persons;Population;premature;prevent;primary outcome;Provider;Recording of previous events;relapse risk;Research;Resources;response;Risk;secondary outcome;Self-Injurious Behavior;Sequential Multiple Assignment Randomized Trial;service delivery;Services;Specific qualifier value;substance use;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide mortality;telehealth;Test Result;Testing;Time;Treatment outcome;treatment response;Vision

PROJECT_TITLE: Reducing Overdose and Suicide Risk in Individuals with OUD and Co-occurring Disorders

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Rehabilitation

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Many older Americans who might like to work are unable to do so because of health-related functional limitations. This project develops a new way of measuring functional abilities that enables direct comparison with occupational requirements. We will use the new measures to identify whether it might be possible to design interventions to restore lost work capacity to individuals whose functional abilities have declined, through accommodation, rehabilitation or retraining.

PI_NAMEs: MAESTAS, NICOLE A (contact);MULLEN, KATHLEEN

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Activities of Daily Living;Affect;Age;American;Area;Bathing;burden of chronic illness;Cognitive;cognitive function;college;Data;Deaths of despair;design;Distress;Economic Factors;Education;Elements;Epidemic;functional decline;Future;Goals;Health;health assessment;health difference;healthy aging;human capital;human old age (65+);improved;Individual;Industry;Intervention;Knowledge;Labor Forces;Licensing;Life;Life Cycle Stages;life span;Light;Link;Literature;Measurement;Measures;Methodology;Methods;middle age;Motion;Occupational;Occupations;older adult;Personal Satisfaction;Persons;Physical Function;Population;Positioning Attribute;Premature Labor;Process;Production;Productivity;professional atmosphere;psychosocial wellbeing;Rehabilitation therapy;Research;response;Risk;Running;Sampling;Scientific Advances and Accomplishments;Sensory;Shapes;skills;social;social factors;Surveys;therapy design;Training;Translating;trend;Vocational rehabilitation;Work;Workplace

PROJECT_TITLE: Assessment of Health-Related Work Capacity to Improve Independence of Older Adults

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ORG_CITY: EDINBURG

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

PHR: Narrative:  Human immunodeficiency virus 1 (HIV-1) causing AIDS is currently treatable but not curable because the HIV virus cannot be eradicated from its reservoir organs like GALT. Our new Microfold-cell based nanodrug formulation can fulfill this dual aim by introducing the concept of smart nano-technology with targeted drug delivery to GALT and potential reduction of HIV reservoir. These efforts can accelerate the discovery of novel agent targeting existing viral reservoirs with a long-term suppressive antiviral activity.

PI_NAMEs: ROY, UPAL  (contact)

PROGRAM_OFFICER_NAME: PROTOPOPOVA, MARINA

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Acute;Anti-HIV Agents;Anti-HIV Therapy;Anti-Retroviral Agents;Antibodies;Antigens;antiretroviral therapy;Area;Bacteria;Binding;capsule;Cause of Death;CD34 gene;Cell model;Cells;cellular targeting;Collaborations;Complex;Country;Data;Digestion;Disease;Dose;drug action;Drug Delivery Systems;Drug Formulations;Drug Kinetics;drug release profile;Drug Targeting;Encapsulated;Enteral;Environment;Epithelial Cells;Epithelium;Formulation;Gastrointestinal tract structure;Glycoproteins;Goals;Gut associated lymphoid tissue;HIV;HIV-1;Immune;improved;In Vitro;in vivo;Inbred BALB C Mice;Infection;innovation;Institution;interest;Intestines;Legal patent;Link;Lymphoid Follicle;Lymphoid Tissue;M cell;Mediating;Metabolic;Metabolism;Modeling;mortality;Mucosal Immune System;Mus;nanocarrier;nanodrug;nanoformulation;nanomedicine;Nanotechnology;next generation;NIH Office of AIDS Research;North Carolina;novel;Oral;Oral Administration;Organ;Patients;Persons;Peyer's Patches;Phagocytes;Pharmaceutical Preparations;Pharmacists;pharmacokinetics and pharmacodynamics;Pharmacology Study;Phase;Physiology;Pluronics;Polymers;Property;Publications;Publishing;Recommendation;Recording of previous events;Research;Research Priority;Residual state;Resources;Safety;side effect;Site;Specialized Epithelial Cell;Stomach;Structure;Surface;targeted agent;targeted delivery;technology platform;Therapeutic;therapy outcome;Time;Tissues;Toxic effect;transcytosis;Treatment Efficacy;Treatment outcome;United States National Institutes of Health;Universities;Viral Physiology;Viral reservoir;Virus;Virus Replication;Work

PROJECT_TITLE: A targeted anti-HIV drug delivery to the GALT

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Hematology;Infant Mortality;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Anemia of prematurity occurs in nearly all very low birth weight (VLBW; birth weight < 1,500 grams) infants who survive the initial postnatal course, and its main cause is blood loss from routine phlebotomy for its diagnosis. The proposed research project will develop a new image analysis algorithm (IAA) that analyzes full structural information of clinical pallor in fingernail photos to enable accurate, non-invasive prediction of blood hemoglobin level and anemia risk among VLBW infants. We will develop various data-driven tools that leverage longitudinal, patient-specific clinical data and IAA predictions to achieve the overarching clinical goal of minimizing the number of invasive blood sampling procedures throughout the care continuum for VLBW infants.

PI_NAMEs: MANATUNGA, AMITA K. (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Address;Adult;Agreement;Algorithmic Analysis;Algorithms;Anemia;Beds;Behavior;Birth Weight;Blood;Blood specimen;Characteristics;Clinical;Clinical Data;clinical decision-making;Clinical Laboratory Improvement Amendments;clinically significant;Color;Communication;Complement;Complete Blood Count;Complex;Continuity of Patient Care;Data;Data Analyses;design;Devices;Diagnosis;diagnostic tool;dimension reduction;Dimensions;Ensure;Goals;Hemoglobin;Hemoglobin concentration result;Hemorrhage;Heterogeneity;High-dimensional Modeling;Hybrids;Image;Image Analysis;improved;Infant;infant monitoring;Inflammatory;Inflammatory Bowel Diseases;intestinal injury;Knowledge;Laboratories;learning strategy;Least-Squares Analysis;Linear Regressions;longitudinal care;Longitudinal Studies;Low Birth Weight Infant;Measurement;Metadata;Methods;Modality;Modeling;Monitor;Nature;Necrotizing Enterocolitis;Neonatal Intensive Care Units;neurodevelopment;non-invasive imaging;non-invasive monitor;noninvasive diagnosis;novel;Pain;Pallor;Patients;Pattern;Performance;Physicians;Physiological;Population;postnatal;postnatal period;prediction algorithm;premature;Premature Birth;Principal Component Analysis;Procedures;Recording of previous events;recruit;Reporting;Research Project Grants;response;Risk;Screening procedure;smartphone application;Source;Specific qualifier value;statistical learning;Structure;Structure of nail of finger;Subgroup;Testing;Time;tool;Training;unsupervised learning;user friendly software;user-friendly;validation studies;Venous blood sampling;Very Low Birth Weight Infant

PROJECT_TITLE: Developing statistical image analysis tools for non-invasive monitoring of anemia in low birth weight infants

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative Mindfulness-based smartphone apps have surged in popularity in recent years (e.g., the Headspace app has over 42 million users). An estimated 11% of U.S. adolescents have used mindfulness apps as a means of coping with symptoms of depression and anxiety, which increase substantially during the adolescent years, and which have been repeatedly linked to rumination in youth. The research activities of the proposed R01 will investigate the underlying neural and cognitive mechanisms that account for the beneficial effects of these apps on rumination, and a machine learning algorithm will be developed to predict which specific adolescents are expected to benefit from app-based mindfulness training.

PI_NAMEs: WEBB, CHRISTIAN ANTHONY (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Accounting;active control;Address;Adolescent;Adverse effects;Adverse event;adverse outcome;Affective;Age;algorithm development;Algorithms;American;Anxiety;anxiety symptoms;Attention;attentional control;Brain;Cellular Phone;Characteristics;Clinical;Clinical Trials;Cognitive;cognitive task;Communication;Control Groups;coping;cost;cost effective;Coupled;depressive symptoms;Development;Diagnostic;Ecological momentary assessment;efficacy evaluation;Elasticity;Emotions;experience;functional MRI scan;Goals;Grain;improved;Individual;Intervention;kernel methods;Link;Machine Learning;machine learning algorithm;machine learning model;Measures;Mediating;Mental Depression;mindfulness;mindfulness meditation;Mindfulness Training;Modeling;National Center for Complementary and Integrative Health;neural;Neurobiology;neuromechanism;Online Systems;Outcome;outcome prediction;Panic;Patient Self-Report;Pattern;personalized medicine;personalized predictions;Persons;post intervention;predicting response;Predictive Value;Prevalence;Probability;Prognosis;programs;Protocols documentation;psychosocial;Randomized;Recommendation;Research;Research Activity;Rest;Risk Factors;Risk-Benefit Assessment;rumination;Sensitivity and Specificity;skills;smartphone application;Strategic Planning;Surveys;Symptoms;Teenagers;Testing;Thinking;Work;Youth

PROJECT_TITLE: Mechanisms and Predictors of Change in App-Based Mindfulness Training for Adolescents

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Prevention;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative There is much controversy surrounding breast cancer screening guidelines, resulting in women making individual choices regarding their screening, in consultation with their physician. Unfortunately, there is insufficient information available to women as to the benefit of screening mammography for them as an individual. Our research goal is to develop a near-term mammography-detectable breast cancer risk marker using a new image transformation, deep learning, and statistical approach for longitudinal data on serial mammograms that will help women choose their own personalized protocol in consultation with their doctor.

PI_NAMEs: LEE, JUHUN  (contact)

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: Advocate;Age;age stratification;Age Years;Breast Cancer Detection;Breast Cancer Risk Factor;breast density;Breast Magnetic Resonance Imaging;cancer risk;Collection;Confusion;Consensus;Consultations;convolutional neural network;Data;data curation;Data Set;Databases;deep learning;Development;Diagnosis;digital;Effectiveness;Frequencies;Goals;high risk;High Risk Woman;Image;imaging biomarker;Imaging Techniques;improved;Individual;Lateral;Life;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Medical center;Medical Records;Modeling;novel;person centered;personalized predictions;personalized screening;Physicians;Probability;Protocols documentation;Radon;Recommendation;Research;Research Personnel;Resources;Risk;Risk Factors;Risk Marker;risk prediction;screening;screening guidelines;Screening procedure;Signal Transduction;Specificity;Subgroup;System;Universities;Validation;Woman

PROJECT_TITLE: Developing a personalized breast cancer screening tool using sequential mammograms

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ORG_CITY: BOZEMAN

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: The goal of this project is to streamline access to pharmacologically relevant compounds by developing new catalytic methods for organic synthesis. In particular, this project focuses on controlling the reactivity and selectivity of transition metal catalysts with carbon-heteroatom bonds in the context of cross-coupling reactions. These new methods have the potential to make small molecule synthesis more efficient, thereby decreasing the cost of lead identification and optimization in the drug discovery process.

PI_NAMEs: NEUFELDT, SHARON  (contact)

PROJECT_TERMS: base;Biomedical Research;Carbon;catalyst;Chemicals;Cobalt;cost;Coupling;drug discovery;Future;Goals;improved;Iron;Lead;Metals;Methods;Organic Synthesis;pharmacologic;Phenols;Process;rational design;Reaction;Site;small molecule;System;Toxic effect;Transition Elements;Work

PROJECT_TITLE: Improving Small Molecule Synthesis by Controlling Reactions between Transition Metals and Carbon-Heteroatom Electrophiles

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Services;Liver Disease;Patient Safety;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The need for surgeries in patients with cirrhosis is increasing, however predicting their surgical risk is complex. Current tools are inadequate as they are not specifically designed to predict surgical risk, do not incorporate important variables such as surgery type, and are poorly calibrated. This proposal will use population-level data to derive and validate a novel cirrhosis surgical risk calculator, incorporate key stakeholder feedback to implement a web application, and use decision analysis to demonstrate the application of the tool in practice.

PI_NAMEs: MAHMUD, NADIM  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Acute Cholecystitis;Address;Age;American;Award;Biometry;Calibration;Cardiac;Child;chronic liver disease;Cirrhosis;Clinical;clinical care;clinical center;clinical epidemiology;clinical implementation;clinical practice;cohort;Complex;Conceptions;Counseling;Data;Data Set;Databases;Decision Analysis;Decision Making;design;Development;Discrimination;disease classification;Educational workshop;end stage liver disease;Etiology;experience;Feedback;Fostering;Funding;Future;General Population;Goals;Grant;Health Policy;Health system;Hepatitis C;Heterogeneity;Hospitals;Impairment;improved;innovation;Knowledge;Laboratories;Literature;Liver diseases;markov model;Medical;meetings;Mentorship;Methods;minimally invasive;Modeling;Modernization;mortality;mortality risk;Natural History;nonalcoholic steatohepatitis;novel;operation;Operative Surgical Procedures;Orthopedics;palliation;Pathway interactions;Patient Selection;Patients;Pennsylvania;Perception;Policy Research;Population;Positioning Attribute;Postoperative Period;predictive modeling;predictive tools;prognostic;prognostic tool;Provider;Qualitative Methods;Qualitative Research;Quality of life;Relative Risks;Research;Research Methodology;Research Personnel;Retrospective Studies;Risk;Risk Estimate;Risk Factors;risk prediction;risk prediction model;risk stratification;Sample Size;Schools;Severities;Severity of illness;Societies;Sodium;statistics;Structure;Surgeon;surgical risk;symposium;System;Techniques;tool;United States National Institutes of Health;Universities;Validation;Veterans;Veterans Health Administration;web app

PROJECT_TITLE: Improving Surgical Risk Prediction and Decision Making among Patients with Cirrhosis


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: Columbus

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative Acquired and genetic hemolytic disease states present significant levels of free heme and cell-free hemoglobin in the circulation. In this proposal, we propose to engineer a novel dual functional heme and hemoglobin scavenger complex consisting of apohemoglobin-haptoglobin that can reduce the side-effects associated with in vivo exposure to heme and hemoglobin. This work is significant since it proposes a novel therapeutic agent that can be used to treat the side-effects associated with various hemolytic disease states.

PI_NAMEs: BUEHLER, PAUL WERNER;CABRALES, PEDRO ;IRWIN, DAVID CHARLES;PALMER, ANDRE FRANCIS (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Adverse effects;Affinity;apohemoglobin;Apoproteins;Binding;Biochemical;Biological Availability;Biomedical Engineering;Biophysics;Blood;Blood Vessels;Cardiovascular Diseases;Cells;Chronic Disease;Circulation;clinically relevant;Complex;dimer;Disease;Dorsal;Drug Kinetics;Drug Metabolic Detoxication;effectiveness evaluation;efficacy evaluation;Engineering;Evaluation;Exercise Test;Exposure to;Genetic;Half-Life;haptoglobin-hemoglobin complex;Haptoglobins;Heme;Hemoglobin;Hemolysis;Hemopexin;Hypertension;Hypoxia;In Vitro;in vivo;Inflammation;instrument;Lung;Lung Diseases;Macrophage;Mediating;Methods;Microvascular Dysfunction;monocyte;Mus;novel;novel therapeutics;Organ;Physiological;Plasma;preclinical evaluation;prevent;protein complex;protein function;Proteins;Protocols documentation;Reaction;Role;side effect;Stream;subcutaneous;Temperature;Testing;Therapeutic;Therapeutic Agents;Tissues;Treatment Efficacy;uptake;vascular inflammation;vasoconstriction;Work

PROJECT_TITLE: Bioengineering a Dual Function Protein Construct to Detoxify Heme and Hemoglobin

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE Non-genetic changes in gene expression promote melanoma progression and metastasis; however, whether aberrant miRNA sequestration by competitive endogenous RNAs (ceRNAs) is involved in this process is unknown. We have discovered a cluster of ceRNA genes located on the frequently gained chromosome 1q region, and found that the mRNA with the greatest predicted ceRNA potential, CEP170, promotes melanoma migration/invasion in vitro and metastasis in vivo. We propose to define the miRNA-dependent oncogenic potential of CEP170 and characterize how the deregulation of downstream miRNAs and ceRNA effectors provokes melanoma metastasis.

PI_NAMEs: KARRETH, FLORIAN  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: 3' Untranslated Regions;Address;Affect;Binding;Binding Sites;Biological;Biology;Cause of Death;cell motility;Cellular biology;chromosome 1q gain;Chromosome Mapping;Chromosomes;Clinical;Code;Cultured Cells;Development;Disease;Drops;Epigenetic Process;Excision;Exhibits;experimental study;Future;Gene Expression;Genes;genetic signature;Genetic Transcription;Genetically Engineered Mouse;Genomic Segment;Genomics;Goals;Human;In Vitro;in vivo;Incidence;Invaded;Laboratories;Link;Malignant - descriptor;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;melanomagenesis;Messenger RNA;Metastatic Melanoma;metastatic process;MicroRNAs;migration;Modeling;Molecular;Molecular Biology;mouse model;mutant;Mutation;Neoplasm Metastasis;non-genetic;novel;Oncogene Deregulation;Oncogenic;Outcome;overexpression;Persons;Phenotype;Porifera;Positioning Attribute;Post-Transcriptional Regulation;posttranscriptional;Process;programs;Proteins;Regulation;Repression;Research;Resources;RNA;RNA I;Role;Series;Survival Rate;Testing;tool;Transcript;tumor;Untranslated RNA;Work

PROJECT_TITLE: Chromosome 1q ceRNAs in Melanoma Progression and Metastasis

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The current project reflects the NIDA priority to address the real-world complexities of substance use through a focus on the high-risk and complex phenomenon of polysubstance use; a behavior that substantially increases the risk of overdose mortality. The goal of this application is to use a rigorous mixed-method approach to develop and validate a novel polysubstance use assessment tool for use with vulnerable subpopulations (i.e., justice-involved, persons who inject drugs) and identify correlates and motivations of polysubstance use behaviors among this population to inform the development of future targeted interventions. The ability to accurately measure polysubstance use among high-risk populations is a critical step towards developing effective strategies for improving substance-related health outcomes of this population.

PI_NAMEs: BUNTING, AMANDA M (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;adverse outcome;Assessment tool;Award;Behavior;career;cognitive interview;Communicable Diseases;Community Workers;Complement;Complex;contingency management;Data;design;Development;Device or Instrument Development;Environment;Face;Focus Groups;follow-up;Frequencies;Funding;Funding Mechanisms;Funding Opportunities;Future;General Population;Goals;Health;Health Services;heroin use;high risk;high risk population;housing instability;improved;Individual;informant;Injecting drug user;Injections;instrument;Intervention;Interview;Investigation;Jail;Justice;Knowledge;Measures;medical schools;Mentors;Methodology;Methods;mortality;Motivation;National Institute of Drug Abuse;New York;novel;Opioid;opioid overdose;opioid user;Outcome;Overdose;overdose death;overdose risk;Pattern;Persons;Pharmaceutical Preparations;polysubstance use;Population;Positioning Attribute;Prevalence;Prisons;Property;psychological distress;Psychometrics;recruit;Reporting;Research;Research Personnel;Risk;Risk Assessment;Risk Behaviors;Route;Sampling;Screening procedure;skills;Sociology;substance use;Substance Use Disorder;Surveys;Testing;therapy development;tool;tool development;Training;Universities;Validation;Vulnerable Populations

PROJECT_TITLE: Development of a novel polysubstance assessment tool for vulnerable subpopulations

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The Einstein Aging Study will apply novel methods to increase understanding of modifiable risk factors for Alzheimer’s disease and associated dementias (ADRD) by examining their effects on cognitive performance and decline prior to ADRD onset. The project will provide new information regarding mechanisms linking exposures to cognitive outcomes and will inform future targeted interventions. The diverse cohort will advance understanding of ADRD disparities.

PI_NAMEs: DERBY, CAROL A. (contact)

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Address;Aging;aging biomarker;Air Pollutants;Air Pollution;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Assessment tool;Autophagocytosis;Behavior;Behavioral;biobank;Biological;Biological Markers;Blood;blood glucose regulation;Blood Vessels;cardiometabolism;Cellular Phone;Characteristics;Childhood;Climate;Clinic;Clinical;Clinical Research;Cognitive;Cognitive aging;cognitive change;cognitive performance;cohort;Collaborations;Communities;Complex;Consensus;Continuous Glucose Monitor;County;Data;Dementia;depressive symptoms;Development;Diabetes Mellitus;Diagnosis;Discrimination;Disease;Disparity;Early identification;early life adversity;Ecological momentary assessment;Economic Factors;Education;Emotional;Environment;Environmental Risk Factor;Epidemiology;ethnic difference;ethnic disparity;Etiology;experience;Exposure to;Financial Hardship;Fostering;Funding;Future;Goals;handheld mobile device;Health;Health behavior;health care availability;Impaired cognition;improved;Individual;Inflammation;Infrastructure;innovation;International;Intervention;Joints;Link;magnetic resonance imaging biomarker;Measurement;Measures;Mentors;Metabolic;Methods;mild cognitive impairment;mobile computing;modifiable risk;Nature;Nerve Degeneration;neuroimaging;neuropathology;next generation;novel;Occupations;older adult;Outcome;Participant;Particulate Matter;Pathology;Pathway interactions;patient engagement;Persons;Pharmacotherapy;Physical activity;Plasma;prevent;preventive intervention;Process;programs;psychosocial;Psychosocial Factor;racial difference;racial disparity;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;Role;Sampling;Scientist;sedentary lifestyle;Sleep;sleep health;social;social factors;synergism;Time;Training;Type 2 diabetic;Vascular Diseases;vascular risk factor;wearable sensor technology;Work

PROJECT_TITLE: Einstein Aging Study


NIH_SPENDING_CATS: Aging;Clinical Research

PHR: NARRATIVE The Administrative Core is responsible for coordinating administrative, scientific, and fiscal activities of the Einstein Aging Study (EAS) Program Project. The cohort is a systematic sample of our diverse Bronx Community. A major strength of this Core is its ability to facilitate efficient and effective sharing of data from the EAS through internal and external collaborations. These collaborations expand the utility of this valuable database by increasing the availability to the broader aging research community as well as to the communities represented by our participants.

PROJECT_TERMS: Address;Advisory Committees;aged;Aging;Agreement;Alzheimer's disease related dementia;Area;Behavior;Biological;Budgets;Clinic;Clinic Visits;Clinical;Cognition;Cognitive aging;cognitive performance;cohesion;cohort;Cohort Studies;Collaborations;college;Committee Members;Communication;Communities;Data;data management;data sharing;Databases;Delaware;Ecological momentary assessment;Elderly;Ensure;experience;Florida;follow-up;Fostering;Foundations;Funding;Goals;Growth;Health;Human;Human Resources;Individual;innovation;Institution;Institutional Review Boards;Leadership;Life Style;lifestyle factors;Maintenance;Medical;Medicine;meetings;Methods;mild cognitive impairment;Monitor;National Institute on Aging;outreach;Participant;participant retention;Patient Recruitments;Pennsylvania;Personnel Management;Physiology;Play;Preparation;Procedures;Productivity;Program Research Project Grants;programs;Progress Reports;psychosocial;Recommendation;recruit;Reporting;Research;Research Activity;Research Personnel;Resource Allocation;Resource Sharing;Resources;Role;Sampling;Schedule;Scientific Advances and Accomplishments;Scientific Inquiry;Services;Site;Structure;Suggestion;Universities

PROJECT_TITLE: Administrative Core