ORG_CITY: Nashville

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: This proposal seeks to develop new combinations of treatment for patients with a subset of melanoma patients with a mutation in the NRAS gene. We will determine whether drugs that block growth of the tumor cells and reprogram the tumors immune cells can be used to make tumors that do not respond to immune checkpoint inhibitors responsive. If successful, these combined treatments will prolong the survival of melanoma patients.

PI_NAMEs: RICHMOND, ANN  (contact);YAN, CHI

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Achievement;Agonist;antagonist;anti-CTLA4;anti-PD-1;anti-PD-L1 therapy;anti-PD1 therapy;Apoptosis;BRAF gene;CD8-Positive T-Lymphocytes;CDK4 gene;CDKN2A gene;Cell Cycle Regulation;Cell Death;cell growth;Cell Proliferation;checkpoint therapy;Clinical Trials;Coculture Techniques;Color;Combined Modality Therapy;CTLA4 gene;CXC Chemokines;Data;Disease;Disease Progression;Environment;epigenetic silencing;Exhibits;experience;Flow Cytometry;Future;Growth;Human;IL8RA gene;IL8RB gene;Immune;Immune checkpoint inhibitor;Immune response;Immunocompetent;Immunotherapy;inhibitor;ipilimumab;Life;Link;Malignant Neoplasms;MDM2 gene;Mediating;MEKs;melanocyte;Melanoma;Melanoma patient;Melanoma Tumor;Metastatic Melanoma;Modeling;mouse model;Mus;mutant;Mutation;Myeloid Cells;Myeloid-derived suppressor cells;Myocarditis;Neoplasm Metastasis;neoplastic cell;NF1 mutation;Nivolumab;novel therapeutic intervention;NRAS gene;Organoids;patient derived xenograft model;Patients;PD-1/PD-L1;Pharmaceutical Preparations;Phase;Phosphotransferases;Play;Process;programs;Proliferating;Protein Array;PTEN gene;recruit;Resistance;Resistance development;response;Role;senescence;Serious Adverse Event;side effect;single-cell RNA sequencing;Stable Disease;standard of care;T-Lymphocyte;Time;Toxic effect;TP53 gene;transcriptome;Translating;Treatment Efficacy;treatment response;tumor;Tumor Angiogenesis;tumor growth;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells;tumorigenesis;Ubiquitination;Visualization

PROJECT_TITLE: New Strategies for Treatment of NRAS Mutant Melanoma after Progression on Immune Checkpoint Inhibitors

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cardiovascular;Chronic Pain;Clinical Research;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Hypertension;Microbiome;Neurosciences;Nutrition;Pain Research;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: DETROIT

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: This project seeks to use an animal model to interrogate novel mechanisms by which diet-derived lipid metabolites and the gut microbial flora influence the development of hypertensive crises in individuals living with spinal cord injury. The proposed research is expected to lead to an improved understanding that will inform future clinical studies. This work is particularly important as current treatment practices are limited to acute management of the symptomatic outcome rather than targeting the underlying cause of this disease process.

PI_NAMEs: O'LEARY, DONAL S (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Acute;Afferent Neurons;Agonist;Animal Model;Animals;antagonist;Autonomic Dysreflexia;Biochemical;Blood Pressure;C Fiber;Cardiac;cardiovascular health;Cardiovascular system;Chronic;chronic pain;Clinical;Clinical Research;colon distension;colorectal distension;Coupling;Custom;defined contribution;Development;Diet;dietary;Dietary Fatty Acid;Disease;dysbiosis;efficacy evaluation;Electrophysiology (science);Emergency Situation;Enteric Nervous System;Exposure to;Fatty Acids;Fecal Impaction;fecal transplantation;Fiber;Frequencies;Future;gastrointestinal;Gnotobiotic;gut dysbiosis;gut microbes;gut microbiota;hemodynamics;Histopathology;Homeostasis;Human;Hyperreflexia;Hypersensitivity;Hypertension;Hypertensive Crisis;Hypertensive Episode;improved;in vivo;Incidence;Individual;insight;instrument;Intestines;Knock-out;Laboratories;Ligands;Limb structure;Link;Linoleic Acids;lipid mediator;Lipids;microbiota;Modeling;Morbidity - disease rate;mortality;Mus;Nerve;neural circuit;Neurons;novel;novel therapeutic intervention;Omega-6 Fatty Acids;Outcome;Paroxysmal Hypertension;Pathogenicity;Patients;Phenotype;Physiological;Polyunsaturated Fatty Acids;Population;Preparation;prevent;Process;Production;Randomized;rational design;Rattus;Reflex action;Regulation;Research;response;Rodent;Role;Sensory;small molecule inhibitor;Spinal Cord;Spinal cord injury;Stimulus;Systemic blood pressure;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;treatment strategy;TRPV1 gene;Vasoconstrictor Agents;Virulence Factors;Visceral;Work

PROJECT_TITLE: Regulation of Viscerosensory Sympathetic Reflexes: The Role of Diet-Derived Lipid Mediators.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-D(90)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Nutrition;Obesity;Patient Safety

ORG_CITY: CLEVELAND

ORG_DEPT: SURGERY

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE: The proposed research is relevant to public health as the incidence of gastroparesis has been rapidly increasing, partially attributable to growing diabetes prevalence. Gastroparesis causes a significant detriment to quality of life, and treatment consumes a considerable amount of healthcare resources, including frequent hospitalization. Current therapeutic options for gastroparesis management do not adequately address this growing public health concern, and novel interventions with established efficacy will be required, particularly once the disease becomes medically refractory.

PI_NAMEs: ALLEMANG, MATTHEW THOMAS (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Address;Albumins;Anatomy;Anti-emetics;Bolus Infusion;Chronic;Clinical;Clinical Trials;Colloids;Consumption;Developed Countries;Devices;Diabetes Mellitus;diabetic;Diet Modification;Discipline of Nuclear Medicine;Disease;Double-Blind Method;early satiety;efficacy evaluation;egg;Egg White;Electric Stimulation;Electric Stimulation Therapy;Endoscopy;Epidemic;Etiology;Fatty acid glycerol esters;Food;Functional disorder;functional outcomes;Gastrectomy;Gastric Bypass;Gastric Emptying;Gastric Pacemakers;gastric retention;Gastrointestinal Motility;Gastroparesis;Goals;Healthcare;Hospitalization;Hour;Iatrogenesis;improved;Incidence;indexing;innovation;Intake;Intervention;Label;Laparoscopic Surgical Procedures;Malnutrition;Measures;Mechanics;Medical;Mission;Modality;Morbidity - disease rate;Motility;National Institute of Diabetes and Digestive and Kidney Diseases;Nausea;Nausea and Vomiting;novel;novel therapeutics;Obstruction;Operative Surgical Procedures;Oral;Patients;Pharmaceutical Preparations;Phase;Placebo Control Effect;preservation;Prevalence;Procedures;prospective;Prospective Studies;Public Health;Pyloric sphincter structure;pyloroplasty;Pylorus;Quality of life;Questionnaires;Randomized;Refractory;Reporting;Research;Resources;Retrospective Studies;Risk;Safety;side effect;Small Intestines;Solid;Stomach;Stomach Diseases;Sulfur;Surveys;symptomatic improvement;Symptoms;System;Technetium 99m;Techniques;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Uses;Time;United States Food and Drug Administration

PROJECT_TITLE: Per-Oral Pyloromyotomy (POP) in the treatment of medical refractory gastroparesis : A randomized, sham-controlled trial


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative CLL is the most common leukemia of adults, yet incurable. The most significant risk factor for CLL is a family history of the disease, and we have identified mutations in the ATM gene as associated with CLL. In this work we will further characterize the clinical and biological effects of these mutations, as well as identify other genes associated with CLL risk, with the goal of providing counseling and screening to patients and families.

PI_NAMEs: BROWN, JENNIFER R (contact)

PROGRAM_OFFICER_NAME: CAGA-ANAN, EMILIE CHARLISSE F

PROJECT_TERMS: adult leukemia;Algorithms;Alleles;ATAC-seq;ataxia telangiectasia mutated protein;ATM gene;ATM Gene Mutation;B-Cell Lymphomas;Biological;Biology;cancer predisposition;cancer type;Candidate Disease Gene;Cell Line;CHEK2 gene;Chromatin;Chronic Lymphocytic Leukemia;chronic lymphocytic leukemia cell;Clinic;Clinical;Clinical Protocols;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Counseling;Dana-Farber Cancer Institute;Data;Data Set;Development;Disease;disorder risk;DNA Repair Gene;Enrollment;epigenomic profiling;exome sequencing;Family;Family Cancer History;Family history of;First Degree Relative;Gene Targeting;Genes;Genetic;genetic linkage analysis;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic study;genetic testing;genetic variant;Genome;genome sequencing;genome wide association study;Genomics;Germ Lines;Germ-Line Mutation;Goals;Grant;Hematologic Neoplasms;Heritability;high risk;Hodgkin Disease;improved;Individual;Indolent;Investigation;Literature;Lymphoma;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Methodology;Methods;Mutation;Non-Hodgkin's Lymphoma;North America;novel;Odds Ratio;Pathogenicity;patient population;patient subsets;Patients;polygenic risk score;Population;population based;Population Control;Predisposition;Privatization;prospective;protein function;rare variant;Recording of previous events;Registries;Resources;Risk;Risk Factors;risk variant;Role;screening;Single Nucleotide Polymorphism;Site;Solid Neoplasm;Susceptibility Gene;The Cancer Genome Atlas;Time;Tissue Banks;Transcriptional Regulation;transcriptome sequencing;tumor;Untranslated RNA;Variant;whole genome;Work

PROJECT_TITLE: Genetic Predisposition to Chronic Lymphocytic Leukemia (CLL)

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Age- and disease-related changes in sleep are thought to play a direct role in cognitive impairments and Alzheimer’s disease pathophysiology. Sleep enhancement is a promising long-term, low cost, feasible intervention to mitigate excitotoxicity which may cause cognitive impairments and leave neurons vulnerable to Alzheimer’s disease pathology. The present study will examine whether habitual slow-wave sleep enhancement ameliorates neuroimaging markers of excitotoxic hyperactivation, Alzheimer’s disease pathophysiology, and cognitive performance in older adults with and without significant Aβ deposition.

PI_NAMEs: WILCKENS, KRISTINE ANN (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: abeta accumulation;abeta deposition;Address;Adult;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;Apolipoprotein E;Beds;Behavior Therapy;Behavioral;behavioral sleep intervention;behavioral study;Biological;Biological Assay;Cognition;Cognitive;cognitive change;cognitive function;cognitive performance;cognitive testing;cost;Dementia;Deterioration;Disease;Education;Elderly;excitotoxicity;executive function;Exhibits;Functional disorder;Functional Magnetic Resonance Imaging;Glutamate Receptor;Health behavior;Hippocampus;Home;human old age (65+);Impaired cognition;improved;improvement on sleep;indexing;Intervention;intervention effect;Link;Mass Spectrum Analysis;Measures;Mediating;Memory;memory retention;Nerve Degeneration;neuroimaging;neuroimaging marker;Neurons;neurotoxic;non rapid eye movement;Nonpharmacologic Therapy;normal aging;older adult;Pathway interactions;pharmacologic;Pittsburgh Compound-B;Plasma;Play;Positron-Emission Tomography;pre-clinical;preservation;Process;Proteins;Race;Research;Retirement;risk mitigation;Risk Reduction;Role;sex;Sleep;Sleep Apnea Syndromes;sleep behavior;sleep difficulty;Sleeplessness;Slow-Wave Sleep;Synapses;Therapeutic Intervention;Time;uptake

PROJECT_TITLE: Slow-wave sleep enhancement in those at risk for Alzheimer's disease: Links with memory, excitotoxicity, and plasma A-beta


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Infectious Diseases;Physical Injury - Accidents and Adverse Effects

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: We propose an innovative approach to the evaluation and treatment of post-traumatic infection by developing methodology and analytic tools optimized for application of indocyanine green (ICG)-based dynamic contrast- enhanced fluorescence imaging (DCE-FI) to objectively measure bone perfusion and use this data to guide surgical debridement of devitalized bone. The scientific premise of this project is based on our preclinical and pilot clinical study demonstrating that real-time intraoperative ICG-based DCE-FI can provide surgeons with objective clinically relevant data regarding blood flow to bone. In the proposed study we will define quantitatively the relationship between perfusion and recurrent bone infection, enhance the capability of DCE-FI to estimate bone perfusion by identifying the correlation between DCE-FI and dynamic contrast-enhanced MRI (DCE-MRI), and optimize bone-specific analytic techniques.

PI_NAMEs: GITAJN, IDA L (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 3-Dimensional;Adopted;analytical tool;Angiography;Animals;Antibiotics;Biomedical Engineering;Blood flow;Blood Vessels;bone;bone health;Cells;Clinical;Clinical Research;clinically relevant;Collaborations;Color;Communication;Complex;contrast enhanced;cost;Data;data acquisition;Data Analytics;Debridement;Decision Making;Defect;Evaluation;Excision;experience;Family suidae;FDA approved;Fluorescence;fluorescence imaging;fluorescence-guided surgery;Fracture;Funding;Goals;hemodynamics;high risk;Human;Image;imaging modality;Immune;Implant;implementation measures;improved;Indocyanine Green;Infection;infection rate;infection risk;Infrastructure;Injury;innovation;Kinetics;limb loss;loss of function;Magnetic Resonance Imaging;Measurable;Measurement;Measures;metallicity;Methodology;Methods;Modeling;Morbidity - disease rate;musculoskeletal injury;Nutrient;Operating Rooms;Operative Surgical Procedures;Orthopedic Surgery;Orthopedics;Osteomyelitis;Oxygen;Palpation;Patients;Perfusion;Phase;Play;Population;porcine model;Positron-Emission Tomography;pre-clinical;Prediction of Response to Therapy;prevent;Procedures;prospective;Radiology Specialty;Recurrence;recurrent infection;Repeat Surgery;Reproducibility;Resolution;risk minimization;Role;Safety;Shock;soft tissue;standard of care;success;Surface;Surgeon;Tactile;Techniques;Time;tool;Translating;translational barrier;trauma centers;Trauma patient;Treatment Failure;validation studies;Variant;Vascular blood supply;Visual;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Real-time fluorescence-based measurement of bone perfusion in post-traumatic infection

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Narrative The proposed studies will contribute to public health by increasing our knowledge of the functional alterations that lead to the cognitive and behavioral deficits associated with fetal alcohol spectrum disorders, which is among the most common neurodevelopmental diseases in the United States. These studies will determine the consequences of alcohol exposure during the rodent equivalent of the last trimester of human pregnancy on a specialized brain circuit that helps individuals self-regulate to achieve their goals, providing new avenues for the development of more effective treatments against this disorder.

PI_NAMEs: VALENZUELA, CARLOS FERNANDO (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Affective;alcohol consequences;alcohol effect;alcohol exposure;Applications Grants;Area;autism spectrum disorder;Behavioral;Biological;Brain;Brain region;Cell Nucleus;Cells;Cerebellar Cortex;Cerebellar Nuclei;Cerebellum;Cerebral cortex;Clinical Research;Cognition;Cognitive;Cognitive deficits;cognitive function;Coupled;Development;Disease;effective intervention;effective therapy;Electrophysiology (science);Emotions;Equilibrium;Executive Dysfunction;executive function;Feedback;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Foundations;Future;Glutamates;Goals;Golgi Apparatus;granule cell;Health;high reward;high risk;Human;Impairment;improved;in vivo;Individual;innovation;Intervention;Knowledge;Label;Lesion;Limb structure;Link;Lobule;Maps;Mediating;Motor;motor learning;Motor Skills;Mus;National Institute on Alcohol Abuse and Alcoholism;Neocortex;neurobehavioral;neurobiological mechanism;Neurodevelopmental Disorder;neuron apoptosis;neuronal circuitry;Neurons;neuropsychiatric disorder;novel;novel therapeutic intervention;optogenetics;Output;Pontine structure;Pregnancy;Public Health;Rattus;Research;Research Priority;Rewards;Rodent;Role;Schizophrenia;Slice;Synapses;System;Testing;Thalamic structure;Third Pregnancy Trimester;Time;transmission process;unborn child;United States;vestibular system;Viral;Work

PROJECT_TITLE: Developmental Alcohol exposure and cerebro-cerebellar circuits

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Neurodegenerative;Neurosciences;Nutrition;Obesity;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: SALT LAKE CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: This ancillary study by adding objective measures of sedentary behavior and physical activity levels will improve the scientific yield of the parent PREVENTABLE trial to test 1. Whether sedentary behavior is a risk factor for dementia and 2. Whether statins improve/ decrease physical activity levels in adults aged 75 years or older.

PI_NAMEs: BEDDHU, SRINIVASAN  (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Accelerometer;Activities of Daily Living;Address;Adult;Age;aged;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Ancillary Study;atorvastatin;awake;Behavior Therapy;Cardiovascular Diseases;Categories;Classification;cognitive function;Data;Dementia;dementia risk;design;Development;Diabetes Mellitus;Disability outcome;Disability prevention;Energy Metabolism;Evaluation;Event;Exercise;experience;frailty;Funding;Future;Goals;Hour;improved;Incidence;Individual;Intervention;Knowledge;Lifting;Light;light intensity;Lipids;longitudinal, prospective study;Measures;Meta-Analysis;Metabolic;mild cognitive impairment;mortality;multidisciplinary;Obesity;Observational Study;older adult;Older Population;Outcome;Parents;Participant;Patient Self-Report;Phase;Physical activity;Physical Function;physical inactivity;physically handicapped;placebo group;Placebos;Positioning Attribute;Posture;preservation;prevent;Probability;prospective;Public Health;Publishing;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Research Personnel;Resources;Rest;Risk;Risk Factors;Role;Running;sedentary;sedentary lifestyle;Strenuous Exercise;synergism;Technology;Testing;Time;tv watching;vigorous intensity;Walking;Weight

PROJECT_TITLE: Objectively Measured Sedentary Behavior and Physical Activity in PREVENTABLE Study


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Social Determinants of Health

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Traumatic injury causes significant mortality and morbidity beyond just the physical damage from the initial traumatic event. This grant will train physicians to become investigators who study the basic biology of how trauma alters the immune system, clinical care of trauma patients, social determinants of trauma and trauma outcomes.

PI_NAMEs: KENZIK, KELLY  (contact);REMICK, DANIEL G.

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TITLE: Impact of Biological, Clinical, and Social Determinants on Trauma and Trauma Outcomes


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: ITHACA

ORG_DEPT: ZOOLOGY

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Infections by bacteria, fungi and viruses have profound impacts on their hosts. This training program will provide postdoctoral scholars with state-of-the-art, highly interdisciplinary training in how molecular interactions between host and microbe drive host traits and physiological state, including the physiology of disease. Research training will be coupled with substantial professional development to launch trainees into rewarding academic and non-academic careers.

PI_NAMEs: LAZZARO, BRIAN  (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Disease;host-microbe interactions;trait

PROJECT_TITLE: Host-Microbe Interactions that Determine Host Traits and Disease

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: NEW HAVEN

ORG_DEPT: CHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Catalytic C-H bond functionalization has emerged as a powerful approach in organic synthesis for the discovery and production of new pharmaceuticals. The next generation C-H bond functionalization methods described in this proposal will enable the rapid assembly of pharmaceutically relevant compounds, including complex architectures, from simple and readily available inputs. As they are developed, these synthetic methods will be applied to the discovery and optimization of potent and selective ligands to challenging biomolecular targets relevant to the treatment of unmet medical conditions.

PI_NAMEs: ELLMAN, JONATHAN A (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Next-generation C-H functionalization methods for organic synthesis and their applications to biological inquiry


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Prevention

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE  Hyperglycemia in patients with T2DM is initially treated with metformin coupled with intentional caloric restriction, which is difficult to sustain due to multiple barriers, including acquiring the necessary knowledge, teaching the intervention, cost of delivery and potential burden on quality of life. In contrast to intentionally restricting calories, time restricted eating (TRE), presents a simplified view of eating focused on restricting the eating window, which allows ad libitum intake per their dietary preferences during a daily fixed eating window. We propose a 24 week feasibility study to test if TRE is a viable alternative to Caloric Restriction in improving glycemic measures while accounting for weight loss in overweight/obese patients [BMI:25-35 kg/m2] with metformin-only treated Type 2 diabetes.

PI_NAMEs: CHOW, LISA SENYE (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Accounting;actigraphy;Address;Age;Behavioral;Body mass index;Body Weight Changes;Body Weight decreased;Caloric Restriction;Calories;Cellular Phone;Clinical Trials;Confusion;Continuous Glucose Monitor;cost;Coupled;Data;Data Reporting;Diabetes Mellitus;dietary;Dietitian;Disease;Eating;Educational process of instructing;Energy Intake;Feasibility Studies;Food;glycemic control;Glycosylated hemoglobin A;Goals;Home;Hour;Hyperglycemia;improved;innovation;Intake;Intervention;Knowledge;Measures;men;Metformin;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;obese patients;Outcome Assessment;Overweight;Participant;Patient Participation;Patient Self-Report;Patients;Persons;Physical activity;Play;Population;Prediabetes syndrome;preference;primary outcome;programs;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Technology;Testing;Time;Time-restricted feeding;Translating;transmission process;virtual visit;Visit;Weight;Weights and Measures

PROJECT_TITLE: Time Restricted Eating As a Viable Alternative to Caloric Restriction for Treating Hyperglycemia in a Population with Type 2 (T2DM) diabetes

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Muscular Dystrophy;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE. This work aims to identify and target the mechanisms which cause the replacement of muscle fibers with fatty tissue after injury. Such an advance will have major implications for muscular dystrophy and other degenerative diseases where fatty replacement of muscle fibers leads to progressive and debilitating muscle weakness.

PI_NAMEs: HOGARTH, MARSHALL  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Adipocytes;Adipose tissue;Adopted;Annexins;Apoptosis;Batimastat;Calcium;Cells;Chronic;Clinical;Clinical Research;Degenerative Disorder;Disease Progression;drug efficacy;Drug usage;Duchenne muscular dystrophy;DYSF gene;dysferlinopathies;effective therapy;Event;Exercise;extracellular;Failure;Fiber;Goals;Homeostasis;Immune;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;Injury;Life;Limb-Girdle Muscular Dystrophies;lipid biosynthesis;Lipids;Macrophage;Mediating;mouse model;Mus;Muscle;muscle degeneration;Muscle Fibers;Muscle function;muscle regeneration;Muscle Weakness;Muscular Atrophy;Muscular Dystrophies;Mutation;myogenesis;Myopathy;Natural regeneration;Nature;new therapeutic target;novel;Onset of illness;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Population;Preclinical Testing;prevent;Process;progenitor;Proliferating;repaired;Research;Role;Severity of illness;Signal Transduction;single-cell RNA sequencing;smoothened signaling pathway;stem cell fate;stem cell niche;stem cell proliferation;Symptoms;Testing;Therapeutic;transcriptome sequencing;Transforming Growth Factor beta;Work

PROJECT_TITLE: Modulating Fibro/Adipogenic Precursors to Prevent Adipogenic Replacement of Muscle

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Cellular polarity is an essential feature of organogenesis and tissue development and homeostasis in general. The regulation and maintenance of the epithelial planar cell polarity (PCP) feature is linked to many diseases, ranging from deafness and infertility to neural tube closure defects and ciliopathies, and also cancer (several PCP determinants are tumor suppressors or proto-oncogenes). This application addresses the cell biology and molecular regulation of PCP establishment, which is of high significance for many medical disorders.

PI_NAMEs: MLODZIK, MAREK  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Address;Adult;Affect;Apical;beta catenin;Biological;Cell Adhesion;Cell division;Cell Polarity;Cells;Cellular biology;Chest;Cilia;ciliopathy;Complex;convergent extension;Cytoplasm;Cytoskeleton;deafness;Defect;Development;Disease;Dissection;Drosophila genus;Epithelial Cells;Epithelium;experimental study;Fatty acid glycerol esters;fluidity;gastrulation;Genetic Screening;Homeostasis;human disease;Infertility;insight;Kinesin;Labyrinth;Ligands;Link;Maintenance;Malignant Neoplasms;Mammals;Mediating;Medical;member;Membrane;Microtubules;Molecular;Neural Tube Closure;Nuclear Translocation;Organ;Organogenesis;Pathway interactions;Pattern;Physiological;planar cell polarity;polarized cell;Process;Proteins;Proto-Oncogenes;receptor;Regulation;Research;Respiratory System;response;Role;Signal Transduction;Skin;Specificity;stem cells;Structure;Tissues;Tumor Suppressor Proteins;Wing;WNT Signaling Pathway

PROJECT_TITLE: Wnt/Frizzled-PCP signaling in development and disease

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Pediatric

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The primary purpose of this Training Program is to develop academic leaders among Neonatologists, Maternal- Fetal Medicine (MFM) Specialists, and Non-Clinician Scientists who know how to work together collaboratively and who have the capacity, based on personal meritorious accomplishment in research, to identify, understand, and solve important problems in Perinatal) Biology and Medicine. Research accomplishment and academic achievement are intimately intertwined goals and are fundamental and inseparable for achieving academic and research success. Through top academic leadership positions, our graduates have made major national impact on research program development and support.

PI_NAMEs: ROZANCE, PAUL JOSEPH (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: perinatal medicine;Training

PROJECT_TITLE: Training in Perinatal Medicine


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE In the first R01 cycle we demonstrated successful microfluidic delivery of small-molecule cancer drug panels to glioblastoma (GBM) xenograft slices as well as to GBM patient tumor slices. In this second R01 cycle, we propose to further develop Oncoslice to integrate multiplexed combination immunotherapy testing of cancer slices with molecular and computational analysis, as well as live imaging of the tumor microenvironment. The platform will be applied to two difficult-to-treat solid tumor types – triple-negative breast cancer (mouse) and pancreatic cancer (mouse and human).

PI_NAMEs: FOLCH, ALBERT  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Acceleration;Address;Antibodies;Antineoplastic Agents;Attention;Biological Assay;biological systems;Biopsy;Cancer Biology;cancer cell;cancer imaging;cancer therapy;CD8-Positive T-Lymphocytes;Cell Communication;Cell Death;Cells;checkpoint therapy;chemotherapy;Clinical Trials;Colorectal;Combination immunotherapy;Combined Modality Therapy;Complex;Computer Analysis;cytokine;Cytotoxic agent;Data;design;Development;drug action;drug discovery;drug mechanism;Drug resistance;drug testing;Endothelial Cells;experimental study;Extracellular Matrix;Fibroblasts;fighting;Gene Expression Profiling;Glioblastoma;Goals;Healthcare;Human;Image;Immobilization;Immune;Immune checkpoint inhibitor;immune modulating agents;immunomodulatory therapies;Immunooncology;in vivo;innovation;insight;Invaded;Investigation;knowledge integration;Label;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Metastatic Neoplasm to the Liver;Methods;Microfluidics;migration;miniaturize;Molecular;Molecular Analysis;molecular phenotype;Molecular Target;Monoclonal Antibodies;Mus;nano-string;Neoplasm Metastasis;neoplastic cell;novel therapeutics;pancreatic neoplasm;Pathway interactions;Patients;PD-1/PD-L1;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;Phenotype;preservation;Production;Protein Array;protein profiling;Proteins;Pyroxylin;recruit;Resources;response;Role;Sampling;Signaling Molecule;Slice;small molecule;Solid Neoplasm;spatiotemporal;Statistical Models;System;Systems Biology;T-Lymphocyte;targeted treatment;Technology;Testing;therapeutically effective;Time;Tissues;tool;transcriptomics;Transgenic Mice;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor heterogeneity;tumor microenvironment;Tumor Promotion;Tumor Tissue;tumor-immune system interactions;tumorigenesis;two photon microscopy;two-photon;Xenograft procedure

PROJECT_TITLE: Interrogating the response of the tumor microenvironment to combination immunotherapy using a microfluidic platform

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE Vessel wall thickening is caused by vascular smooth muscle cell (VSMC)’s plasticity to dedifferentiate into a highly proliferative state or to transdifferentiate into macrophage-like cells, which contributes to atherosclerotic lesion formation and failure of cardiovascular interventions. We will investigate if targeting focal adhesion kinase (FAK) prevents VSMC phenotypic change via epigenetic regulation.

PI_NAMEs: LIM, STEVE  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Apolipoprotein E;Arterial Fatty Streak;Arteries;Atherosclerosis;Biochemical;Cardiovascular system;CD47 gene;Cell Cycle;cell dedifferentiation;Cell Differentiation process;cell motility;Cell Nucleus;Cell Proliferation;Cells;chromatin remodeling;Complex;Cyclin D1;Cytoplasm;Data;Deacetylase;Disease;DNA Methylation;DNA Modification Methylases;Epigenetic Process;epigenetic regulation;Failure;Focal Adhesion Kinase 1;Gene Expression;Genes;Genetic;Genetic Models;Genetic Transcription;Growth Factor;histone modification;Histones;Human;Hyperlipidemia;Inflammatory;Injury;insight;Integrins;Intervention;Intervention Studies;Investments;kinase inhibitor;Macrophage;Mediating;Modeling;Molecular;Molecular Biology;mouse model;Mus;novel;Nuclear;Nucleosomes;oxidized lipid;pharmacologic;Phenotype;Play;prevent;Process;Production;Proliferating;promoter;Protein Tyrosine Kinase;Repression;response;Role;Sampling;Signal Transduction;Smooth Muscle Myocytes;Specimen;Stimulus;Testing;Therapeutic;tool;transdifferentiation;Ubiquitination;vascular injury;Vascular Smooth Muscle

PROJECT_TITLE: Nuclear FAK-mediated VSMC differentiation via epigenetic reprograming invascular diseases

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF DETROIT MERCY

PHR: University of Detroit Mercy’s Integrated Research Initiative for Student Enhancement (I-RISE) with U-RISE program will result in more underrepresented graduates transitioning into biomedical, research-focused advanced degree programs (e.g., Ph.D. or M.D./Ph.D.). We will accomplish these goals through 1) intensive recruitment of underrepresented students to biomedical majors, 2) early introduction to research practices, 3) immersion in culturally-responsive, authentic mentored research experiences, and 4) ongoing and extensive trainee support. The integration of trainee-focused activities throughout the three-year I-RISE with U-RISE program has been carefully planned with the ultimate goal of helping trainees successfully matriculate into graduate biomedical research programs and the biomedical workforce.

PI_NAMEs: BELANGER, RACHELLE MARIE;EVANS, KENDRA REID;KRUKONIS, ERIC S;ROBERTS-KIRCHHOFF, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Address;Applications Grants;Big Data;Biomedical Research;career;career development;Communities;Development;Doctor of Philosophy;Educational Curriculum;Educational process of instructing;Educational workshop;Ensure;Ethics;experience;Fostering;Future;Goals;graduate school;Hour;implicit bias;Institution;Laboratories;laboratory experience;Laboratory Research;Leadership;Mentors;Methods;peer coaching;Positioning Attribute;programs;recruit;Reproducibility;Research;research in practice;Research Personnel;Research Training;Resources;responsible research conduct;role model;Science;scientific literacy;Scientist;Site;skills;Students;success;summer research;Training;Training Activity;undergraduate research experience;undergraduate student;Underrepresented Populations;Universities;Visualization;Writing

PROJECT_TITLE: U-RISE at University of Detroit Mercy

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: The Training Grant in Academic Gastroenterology at Stanford University, in the past 46 years has supported research training to prepare the best-qualified physician-scientists for an investigative career in digestive diseases. Based on the strong track record, environment and pipeline of outstanding trainees, we are committed to provide the best training possible to prepare our fellows as future academic leaders in digestive medicine.

PI_NAMEs: TOROK, NATALIE J. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Gastroenterology;Grant;Training


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: LA JOLLA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Whole genome sequencing technologies have the potential to profile all clinically relevant genetic variants simultaneously in a single genetic test. This project aims to augment existing pipelines to include highly relevant disease variants found in repeat regions that account for over 8% of the genome and are implicated in a large number of Mendelian diseases.

PI_NAMEs: BAFNA, VINEET ;BANSAL, VIKAS ;GYMREK, MELISSA  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Accounting;Address;Affect;algorithm development;Algorithms;analysis pipeline;autism spectrum disorder;Bioinformatics;Biological Sciences;Characteristics;Clinical;clinical sequencing;clinically relevant;Code;cohort;Complex;Cystic Kidney Diseases;Data;Data Set;de novo mutation;Detection;Diagnostic;diagnostic value;Diploidy;Disease;Disease Progression;Epilepsy;experience;Fragile X Syndrome;frontotemporal lobar dementia amyotrophic lateral sclerosis;Future;Gene Duplication;Gene Frequency;genetic testing;genetic variant;Genetic Variation;Genome;genome sequencing;genome-wide;Genomics;Genotype;Germ Lines;Goals;hearing impairment;Hereditary Nonpolyposis Colorectal Neoplasms;Human Genetics;Human Genome;Huntington Disease;improved;Individual;Inheritance Patterns;Inherited Spinocerebellar Degenerations;insertion/deletion mutation;Insulin-Dependent Diabetes Mellitus;Length;Malignant Neoplasms;Mendelian disorder;Methods;Minisatellite Repeats;Mutation;nanopore;Nerve Degeneration;novel;Overlapping Genes;Pathogenicity;PMS2 gene;Population;Population Genetics;rare mendelian disorder;Repetitive Sequence;Sampling;Sequence Analysis;Short Tandem Repeat;Single Nucleotide Polymorphism;success;Tandem Repeat Sequences;Technology;Testing;tool;trait;Variant;whole genome

PROJECT_TITLE: Refining Mendelian disease analysis via detection of clinically relevant repeat variants

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Narrative Misregulation of chromatin states either via misregulation of ATP-dependent chromatin remodeling enzymes or misregulation of heterochromatin is strongly associated with cancer and developmental defects. Yet how chromatin remodeling enzymes work or how heterochromatin is assembled and regulated is poorly understood. This proposal combines biophysical approaches with cellular tests to tackle these challenging questions, with the goal of identifying key steps that are targets for regulation and that can be controlled for therapeutic intervention in the future.

PI_NAMEs: NARLIKAR, GEETA J (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TITLE: ATP-dependent and independent mechanisms of regulating chromatin states

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunotherapy;Lung;Lung Cancer;Nanotechnology;Precision Medicine;Radiation Oncology;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative  Conventional nanoplatforms used to carry and deliver chemotherapeutics suffer from unfavorable biodistribution, poor local retention properties, limited therapeutic efficacy, and adverse toxic effects. In this application, we propose to use a new drug delivery system with preferential lung-targeting and -retention properties, combined with radiation therapy, as alternative therapeutic strategy for treating metastatic pulmonary tumors.

PI_NAMEs: BELLAT, VANESSA  (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: 3-Dimensional;Acceleration;acute toxicity;Adverse effects;analog;Animal Model;Animals;anti-cancer;anticancer activity;antitumor effect;Architecture;Biodistribution;Brain;Breast Cancer Patient;cancer therapy;cancer type;cell killing;Cessation of life;Charge;chemotherapy;Clinical;clinical prognosis;combat;combinatorial;comparative;Complex;Cytotoxic agent;design;Detection;Disease;Disease Progression;Disseminated Malignant Neoplasm;Doxorubicin;Doxorubicin Hydrochloride Liposome;Drug Delivery Systems;drug distribution;effective therapy;Engineering;Ensure;FDA approved;flexibility;Fluorescence Microscopy;Genomics;Goals;Histologic;Hydrophobicity;Hypoxia;Image;Immune;immunogenicity;Immunotherapy;improved;in vivo;Injections;innovation;Ionizing radiation;Kidney;Lesion;Light;liposomal formulation;Liver;Lung;lung lesion;Lung Neoplasms;Lung retention;Malignant Neoplasms;Maps;Mediating;Metabolism;Metastatic Neoplasm to the Lung;metastatic process;Modeling;Molecular;Monitor;mortality;multiple omics;Mus;nanocarrier;nanofiber;nanomedicine;Nanotechnology;nanotechnology platform;Nature;Neoplasm Metastasis;neoplastic cell;novel strategies;novel therapeutic intervention;novel therapeutics;Organ;Outcome;Pathologic;Pathway interactions;Patients;Penetration;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Primary Neoplasm;Property;Radiation;Radiation therapy;Radiation-Sensitizing Agents;response;Shapes;Site;spatiotemporal;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stimulus;success;Surface;synergism;targeted treatment;Techniques;Technology;Therapeutic;therapeutically effective;Time;Tissues;Toxic effect;Translating;Treatment Efficacy;Treatment Failure;Treatment outcome;Treatment-related toxicity;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;tumor xenograft;uptake;Variant;Vascular blood supply

PROJECT_TITLE: Customized nanofibers with preferential lung-targeting properties for treating metastatic pulmonary tumors


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Headaches;Migraine;Neurosciences;Pain Research;Precision Medicine;Prevention

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Migraine affects an estimated 12-15% of the world population, while chronic migraine – which completely disrupts the lives of sufferers – affects close to 3%, accounting for the vast majority of the disability and cost of the disorder. Current clinical criteria are useful for diagnosing episodic and chronic migraine, but they have not necessarily been predictive of progression, and thus are not helpful in identifying subjects at risk. This study will develop and validate sensory measures as predictive biomarkers of migraine progression, generating tools that can identify patients at risk of chronic migraine and allow preventive measures to be taken.

PI_NAMEs: BRENNAN, KEVIN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: ARUDCHANDRAN, RAMACHANDRAN NMN

PROJECT_TERMS: Accounting;Affect;allodynia;Area;Auditory;Auras;Biological Markers;biomarker validation;Brazil;candidate marker;Caring;Chronic;Clinical;clinical risk;Clinical Trials;cohort;comorbidity;cost;Data;Development;Diagnosis;disability;Disabling;Disease;disease prognosis;Disease Progression;Disease remission;Distress;Esthesia;Evaluation;Frequencies;Funding;Goals;Headache;improved;Individual;instrument;Interview;Machine Learning;machine learning method;Measures;Migraine;Modality;model development;Modeling;multimodality;multisensory;Nausea;Nervous System Disorder;Neurologic;novel;novel marker;opioid epidemic;opioid overuse;Pain;Patients;Perception;Performance;Pharmaceutical Preparations;Phase;Phenotype;Phonophobias;Photophobia;Physiological;Physiology;Population;predictive marker;predictive modeling;prevent;preventive intervention;Preventive measure;Prognosis;prognostic;prognostic model;prognostic tool;prognostication;Psychophysics;Questionnaires;Reporting;Research;response;Risk;Risk Factors;ROC Curve;Selection for Treatments;Sensory;sensory input;Severity of illness;sex;Site;Smell Perception;Societies;Statistical Methods;Statistical Models;Symptoms;Testing;tool;Validation;Vertigo;Visual;Work

PROJECT_TITLE: Sensory Amplifications as Biomarkers of Migraine Progression

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Black, Indigenous, and People of Color (BIPOC) women experience profound maternal health disparities in the US, including rising rates of maternal mortality and severe maternal morbidity. This study will develop a Well- Mama intervention for pregnant and postpartum BIPOC women, centered around Community Doula Navigators conducting in-person and telehealth check-ins on 5 priority areas (mental health, cardiovascular symptoms, safety, opioid/substance abuse, and social support), supplemented with virtual support groups and labor support. We will conduct a randomized trial in Chicago IL, Newark NJ, and Baton Rouge LA to test whether the Well- Mama intervention increases BIPOC women’s receipt of prenatal and postpartum care.

PI_NAMEs: SIMON, MELISSA A. (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Address;American College of Obstetricians and Gynecologists;Area;Birth;black women;Black, Indigenous, People of Color;Cardiovascular system;care coordination;Caring;Chicago;Child;cohesion;Collaborations;Communities;Community Health Aides;compare effectiveness;Developed Countries;Discipline of obstetrics;Discrimination;Disparity;distrust;effectiveness-implementation randomized trial;Emergency Situation;Emotional;ethnic disparity;Ethnic Origin;experience;Failure;Feedback;Fostering;Goals;group intervention;Guidelines;Guns;Health;health care availability;health care delivery;health care quality;health disparity;Healthcare Systems;high risk;High-Risk Pregnancy;Home;Hospitals;Hybrids;implementation evaluation;implementation intervention;improved;individual patient;innovation;Institutional Racism;Intervention;intervention effect;intimate partner violence;Knowledge;Lead;low and middle-income countries;Maternal Health;maternal morbidity;Maternal Mortality;maternal outcome;Medical;Medical Care Team;Medical center;medically underserved;Mental Depression;Mental Health;Modeling;mortality disparity;Opioid;Outcome;Patient Care;patient navigator;Patient Selection;Patients;Perception;Perinatal Care;perinatal period;Personal Satisfaction;Persons;postpartum care;Postpartum Period;Postpartum Women;Practical Robust Implementation and Sustainability Model;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;Prenatal care;primary outcome;Public Health;Qualitative Methods;Quality of Care;Race;racial disparity;racism;randomized trial;Recommendation;Resources;Role;Safety;secondary outcome;Self Efficacy;Service delivery model;severe maternal morbidity;Site;skills;social health determinants;Social support;standard care;Substance abuse problem;Support Groups;Symptoms;telehealth;Testing;Time;Underserved Population;Uninsured;uptake;Variant;virtual;Visit;Woman;women of color;Women's Health;Work

PROJECT_TITLE: Enhancing Perinatal Care Support to Improve Maternal Mortality Disparities

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Genetics;Immunization;Immunotherapy;Kidney Disease;Lung;Organ Transplantation;Transplantation;Vaccine Related

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative Despite significant improvement in short-term survival of organ transplants, attrition of transplanted organs over time due to chronic rejection remains a significant clinical problem. Identifying the mechanisms by which memory T lymphocytes, a key cell of the immune system, can persist in transplanted organs and cause damage could lead to novel therapies that enhance long-term graft and patient survival.

PI_NAMEs: LAKKIS, FADI G. (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acute;Address;Affect;Alloantigen;allograft rejection;Allografting;Antigens;Autoimmunity;Automobile Driving;Behavior;Binding Proteins;Biological;Biology;CD8B1 gene;Cell Count;Cell Maintenance;cell motility;Cell Physiology;cell preparation;Cell Proliferation;Cell Survival;Cells;Cellular biology;Characteristics;Chronic;Clinical;cytokine;Dendritic Cells;Disease;experimental study;female reproductive tract;Funding;gastrointestinal transplantation;Gene Expression Profile;Genetic Transcription;Glean;Graft Rejection;Human;Hypersensitivity;Immune;Immune system;Immunity;Immunologic Memory;Immunosuppression;improved;Infection;Injury;insight;Interleukin-15;Interruption;islet allograft;Isoantibodies;Kidney;kidney allograft;Kidney Transplantation;Laboratory Animals;Longevity;Lung;lung allograft;Lung Transplantation;Lymphoid Tissue;Malignant Neoplasms;Memory;Minor Histocompatibility Antigens;Modeling;Molecular;Mucous Membrane;Mus;Names;novel;novel therapeutics;Organ;Organ Survival;organ transplant rejection;Organ Transplantation;Outcome;Pathology;Pathway interactions;Patients;Phenotype;Play;Population;posttranscriptional;Production;Regimen;Research;response;Rodent;Role;Sampling;Site;Skin;Small Intestines;T cell infiltration;T memory cell;T-Lymphocyte;Testing;Therapeutic;Time;Tissue Donors;tissue resident memory T cell;Tissues;transplant model;Transplantation;Tumor Immunity

PROJECT_TITLE: T Cell Memory in Organ Transplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ORG_CITY: CHAPEL HILL

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This project has the potential to change prevention paradigms and alter the staging and strategies for treating patients with newly diagnosed melanoma, a serious skin cancer that leads to approximately 10,000 deaths in the USA each year. The goal is to identify at the time of diagnosis which melanomas are the dangerous, potentially lethal ones that should be treated early and, conversely, which melanomas are very unlikely to lead to recurrence and death, potentially sparing these patients toxic and expensive treatments. We will accomplish this by examining the genetic and immune alterations in tumor samples collected from 1,690 patients diagnosed with melanoma in the year 2000 with 10-year follow-up, allowing us to determine which combinations of tumor alterations identified the melanomas that led to the death of the patients.

PI_NAMEs: ANTON-CULVER, HODA A;BEGG, COLIN B;THOMAS, NANCY E. (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Address;Adjuvant Therapy;Affect;Age;American Joint Committee on Cancer;Benefits and Risks;Biopsy;BRAF gene;Cause of Death;CD3 Antigens;CD8B1 gene;CDKN2A gene;Cell Density;Cells;Cessation of life;Characteristics;Clinical Research;cohort;cost;cost effective;Cutaneous Melanoma;Cyclin-Dependent Kinase Inhibitor 2A;Dangerousness;Data;Data Collection;Development;Diagnosis;Diagnostic Neoplasm Staging;Disease;disease natural history;DNA;Early treatment;effective therapy;Eligibility Determination;Environment;epidemiologic data;Epidemiology;follow-up;Funding;Gender;Genes;Genetic;Germ Lines;Germ-Line Mutation;Goals;high risk;Immune;Immune response;Immune system;Immunologics;Immunotherapy;improved;Incidence;Individual;Integration Host Factors;International;Knowledge;Literature;Localized Disease;Lymphocyte Subset;Malignant Neoplasms;Measures;Mediating;Melanoma;Metastatic Melanoma;Molecular Profiling;mortality;Mutation;Neoplasm Metastasis;neoplastic cell;New Agents;Newly Diagnosed;NF1 gene;Oncogenic;overtreatment;Pathologic;Pathology;Patients;Phenotype;Population;population based;Prevention;Probability;programmed cell death ligand 1;protein expression;PTEN gene;Public Health;Recurrence;Regional Disease;Research;Resources;response;Risk;Sampling;screening;Signal Transduction;Single Nucleotide Polymorphism;Skin Cancer;Somatic Mutation;Staging;Sun Exposure;survival prediction;Systemic Therapy;targeted treatment;Testing;Time;Toxic effect;TP53 gene;tumor;Tumor Burden;tumor progression;Tumor stage;Tumor Suppressor Genes;Tumor Suppressor Proteins;Tumor-Infiltrating Lymphocytes;United States Preventative Services Task Force;Variant;Vital Status

PROJECT_TITLE: Identification of Lethal Melanomas at the Time of Diagnosis

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This project introduces undergraduates who may enter a variety of careers to the underlying demographic social, economic and health dynamics that are impacting society - broadening the base of general knowledge about demographic factors which affect the health and well-being of the population at large. The project will also serve to recruit undergraduates to population and health related careers.

PI_NAMEs: FREY, WILLIAM H (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Address;Affect;American;Area;Award;base;career;career networking;Censuses;cohort;Community Surveys;Computer software;Data;data complexity;data portal;Data Set;Demographer;Demographic Factors;Demography;Discipline;Economics;Educational Curriculum;Educational workshop;Exposure to;Faculty;follow-up;Future;Future Teacher;graduate student;Health;Instruction;instructor;interest;Internet;Knowledge;learning materials;Learning Module;Link;member;mid-career faculty;Participant;Pathway interactions;Personal Satisfaction;Policies;Politics;Population;Population Programs;Population Sciences;Population Study;programs;recruit;Research;Research Personnel;Resources;response;Site;social;Social Sciences;Societies;Sociology;Students;success;summer program;teacher;Teacher Professional Development;Techniques;Time;Training;training opportunity;Training Programs;training project;undergraduate student;Universities;Update;web portal;web site;webinar;Work

PROJECT_TITLE: Using the ACS to Introduce Demographic Approaches in Undergraduate Courses

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative: The objective of this work is to develop novel applications of deep neural networks leveraging ground truth cine DENSE data in order to provide a novel approach to extracting data from cine imaging through machine learning methods, and the application of these methods to a rich dataset with complete CMR, response, and survival data. We expect the results to be highly impactful by providing a new paradigm for imaging-based guidance for CRT patient selection and procedure implementation for use in CMR centers worldwide with or without DENSE.

PI_NAMEs: ZHANG, MIAOMIAO  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Address;Adoption;Agreement;Arrhythmia;Artificial Intelligence;artificial intelligence method;Brain natriuretic peptide;Cardiac;cardiac implant;cardiac magnetic resonance imaging;cardiac resynchronization therapy;Characteristics;Cicatrix;comorbidity;Computer software;Computers;Consumption;Data;Data Set;deep learning;deep neural network;Defibrillators;demographics;design;Detection;Devices;Dimensions;Disease;Echocardiography;Educational process of instructing;Effectiveness;Electronics;Exercise Test;experience;follow-up;functional restoration;Gadolinium;Goals;Grant;Heart;Heart failure;heart function;heart rhythm;Image;imaging study;Implant;implantable device;improved;Inferior;innovation;Institution;Joints;Knowledge;Lead;Left;Life;Location;Longterm Follow-up;Machine Learning;machine learning method;Magnetic Resonance;Maps;Measures;Mechanics;Methods;Modeling;Morbidity - disease rate;mortality;multi-task learning;Myocardial;Network-based;neural network;novel;novel strategies;Outcome;Pacemakers;Patient Selection;Patients;Performance;Procedures;Quality of life;Questionnaires;response;Selection for Treatments;Serum;Site;Specialist;Techniques;Testing;therapy outcome;Time;Tissue Viability;tool;treatment response;Ventricular;Visual;Work

PROJECT_TITLE: Deep Learning To Automate Late Mechanical Activation Detection From Cardiac Magnetic Resonance Images

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research has strong public health significance as it focuses on a population at disproportionate risk for obesity and for whom intervention reach and effectiveness must be markedly improved to reduce existing disparities. The proposed pilot trial will utilize a group randomized, repeated measures design to assess the feasibility, acceptability and preliminary effectiveness of the house chat model as a grassroots approach to lifestyle intervention delivery in a community setting. This project is directly relevant to NIDDK’s priorities related to obesity management among underserved communities.

PI_NAMEs: LAROSE, JESSICA GOKEE;MOSAVEL, MAGHBOEBA  (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Affect;African American;African American population;Aftercare;Age Years;Behavior;Behavior Therapy;Behavioral;behavioral outcome;Black race;Blood Pressure;Body mass index;Body Weight decreased;cardiometabolic risk;cardiometabolism;Clinic;clinically significant;Communities;community based participatory research;Community Health Aides;community intervention;community setting;comorbidity;Competence;cost;Data;design;Development;diabetes prevention program;Diet;Disadvantaged minority;Disparity;Dose;economic disparity;Economically Deprived Population;Effectiveness;Environment;ethnic minority;evidence base;Evidence based intervention;experience;fasting glucose;feasibility testing;Focus Groups;follow-up;Future;Group Meetings;Health;Health behavior change;healthy lifestyle;Home;implementation intervention;improved;Individual;informant;innovation;Intervention;intervention delivery;Interview;lifestyle intervention;literacy;Maintenance;Maps;Masks;Measures;member;Methods;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Needs Assessment;neighborhood disadvantage;Not Hispanic or Latino;novel;Obesity;obesity management;obesity risk;obesity treatment;Outcome;Overweight;Participant;Patient Recruitments;peer;Persons;Physical activity;pilot trial;poor health outcome;Population;Poverty;preventable death;Process;programs;Public Health;racial minority;Randomized;randomized controlled design;randomized trial;recruit;Research;Research Personnel;Research Project Grants;Resources;response;Risk Factors;satisfaction;social;Social Environment;Social Network;socioeconomics;success;Surveys;Testing;Training;Translations;treatment program;underserved community;Underserved Population;United States;Visit;ward;Weight;Weight maintenance regimen;Wellness coaching

PROJECT_TITLE: Using grassroots wellness coaching to enhance reach and sustainability of behavioral weight management

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative: Approximately 7% of older adults diagnosed with cancer have pre-existing dementia. Often, these scenarios require complex decisions integrating information about two significant illnesses and the risks and benefits of potential interventions in the context of the dual diagnoses. The overarching goal of this proposal is to adapt an existing communication tool developed by our team for use in patients with Alzheimer’s Disease or Related Dementias (ADRD) and their care partners, and evaluate if this tool can enhance communication about cognitive impairment in the context of a cancer management decision in discussions between patients with ADRD, their care partners and their oncology clinicians.

PI_NAMEs: MAGNUSON, ALLISON MARIAN (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Acceleration;Advanced Malignant Neoplasm;aging related;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease related dementia;Anxiety;Behavioral;behavioral neurology;Benefits and Risks;Biometry;cancer care;cancer clinical trial;Cancer Patient;cancer therapy;Caregivers;Caring;Climate;clinical diagnosis;clinical encounter;Clinical Oncology;Cluster randomized trial;Cognition;Cognitive;Communication;Communication Tools;Community Clinical Oncology Program;Complex;Cues;Data;Decision Making;Dementia;Depressed mood;Diagnosis;efficacy evaluation;Elderly;Enrollment;Ensure;Equilibrium;experience;Focus Groups;Geriatric Assessment;Goals;Healthcare;Impaired cognition;improved;individual patient;innovation;Intervention;Knowledge;Malignant Neoplasms;Measures;Medical;Methods;Morbidity - disease rate;mortality;multidisciplinary;Nature;older adult;older patient;Oncologist;Oncology;Outcome;Palliative Care;Patient-Focused Outcomes;Patients;Perception;Personal Satisfaction;phase 3 study;Physicians;Population;Population Intervention;post intervention;preference;primary outcome;Process;programs;Qualifying;Quality of life;Questionnaires;Randomized;Recommendation;Regrets;Research;response;Science;secondary analysis;side effect;skills;Symptoms;therapy development;tool;Training;treatment as usual;Universities

PROJECT_TITLE: Enhancing Triadic Communication About Cognition for Older Adults with Alzheimer's Disease or Related Dementias Facing a Cancer Management Decision


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DETROIT

ORG_DEPT: PSYCHOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: There is a critical need to identify the daily social determinants of cardiovascular disease and their biological mechanisms among urban middle-aged and older African American (AA) adults. By adopting a prospective, mixed-method, and multiple-time-scale design, we will work on a sample of 500 AAs aged 55-75 years living in Detroit to determine through ecological measurements the psychosocial stressors that characterize this sample and identify the psychological and biological intermediaries through which psychosocial stressors pose a risk for cardiovascular disease. Our results are expected to have a substantial positive impact because they will contribute to establish a model of the social determinants of cardiovascular disease risk that will inform the identification of culturally relevant targets for the development of behavioral interventions to reduce the risk of cardiovascular disease among urban middle-aged and older AA adults.

PI_NAMEs: ZILIOLI, SAMUELE  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Adopted;Adult;Affect;African American;aged;Anti-Inflammatory Agents;Behavior;Behavior Therapy;Behavioral;biobehavior;Biological;Biological Markers;Blood Pressure;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cellular Phone;Chronic;Clinical;cytokine;Data;deprivation;design;Development;Discrimination;Disease;Ecological momentary assessment;economic disparity;Emotional;Etiology;experience;Exposure to;Family;Future;Goals;Grain;Hair;Health behavior;heart rate variability;Hydrocortisone;IL8 gene;Immune;Individual;individualized medicine;Inflammation;innovation;Interleukin-1 beta;Interleukin-10;Interleukin-4;Interleukin-6;Interview;Link;longitudinal design;Longitudinal Studies;Measurement;Measures;Mediating;Methods;middle age;model development;Modeling;Morbidity - disease rate;mortality;negative affect;Neighborhoods;Neurosecretory Systems;novel;Participant;Pathway interactions;Pattern;perceived discrimination;Persons;Physical activity;Physiological;poor sleep;Population;Prejudice;Process;prospective;Protocols documentation;psychologic;psychosocial;Psychosocial Factor;Psychosocial Stress;psychosocial stressors;Public Health;racial discrimination;racial disparity;racial population;racism;Research;Research Design;residential segregation;response;Rest;Risk Factors;Risk Reduction;Salivary;Sampling;Science;Sleep;Sleep disturbances;Smoking;social determinants;Social isolation;social stressor;socioeconomic disadvantage;standardize measure;Stress;stressor;Structure;Surrogate Endpoint;Technology Assessment;Testing;theories;Time;TNF gene;Treatment/Psychosocial Effects;urban dwelling;Work

PROJECT_TITLE: Stress and Cardiovascular Risk Among Urban African American adults: A Multilevel, Mixed Methods Approach


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: Columbus

ORG_DEPT: SURGERY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE While defects in mitochondrial function are implicated in the pathogenesis of heart failure (HF), translation of mitochondrial-targeted HF therapy to the clinic has not succeeded to date. This project will employ an innovative luminoptogenetic technology to evaluate the therapeutic efficacy of preserving cardiomyocyte mitochondrial function in improving cardiac remodeling and contractile dysfunction in the failing hearts. The findings will not only advance our understanding of the mechanisms connecting mitochondrial dysfunction and pathogenesis of HF, but also lead to the development of a novel synergistic mitochondrial-targeted therapy for HF treatment.

PI_NAMEs: ZHOU, LUFANG  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Adenoviruses;Affect;American;Animal Model;Animals;Antioxidants;Biochemical;Biodistribution;Bioluminescence;Calcium;Cardiac;Cardiac Myocytes;Cause of Death;cell injury;Cell Physiology;Cell Survival;Cessation of life;Clinic;clinical translation;Complex;Cytoprotection;Cytosol;cytotoxicity;Data;Death Rate;Defect;Development;Dilated Cardiomyopathy;dosage;Dose;Drug Kinetics;efficacy evaluation;Equilibrium;Family suidae;Functional disorder;Future;Genes;Goals;Heart;Heart failure;heart function;Heart Mitochondria;Histologic;Histopathology;Homeostasis;Human;Immune response;Immunity;improved;in vivo;Inner mitochondrial membrane;innovation;innovative technologies;Ischemia;Light;light gated;Lighting;Liver;Luciferases;luciferin;Mediating;Membrane Potentials;Metabolic Pathway;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;mitochondrial therapeutics;Modeling;Molecular;mouse model;Mus;mutant;myocardial damage;Myocardial dysfunction;Myocardial Ischemia;Myocardial Reperfusion Injury;Names;neutralizing antibody;novel;novel therapeutic intervention;optogenetics;Organ;Outcome;Oxidation-Reduction;Pathogenesis;Pathologic;Patients;Phenylephrine;Play;pre-clinical;preclinical study;preservation;pressure;Production;Proton Pump;Publishing;Quality Control;Reactive Oxygen Species;redshift;Regulation;Renilla;Reperfusion Injury;Reperfusion Therapy;Rhodopsin;Role;Safety;Satellite Viruses;Signal Pathway;Stress;Survival Rate;synergism;targeted treatment;Technology;Therapeutic;therapeutic target;tool;Toxic effect;Toxicology;transduction efficiency;translational potential;translational therapeutics;Translations;Treatment Efficacy;Treatment Failure;treatment strategy;Ventricular;Whole Blood

PROJECT_TITLE: Synergistically Target Mitochondria for Heart Failure Treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Serious Mental Illness;Social Determinants of Health;Telehealth

ORG_CITY: Springfield

ORG_NAME: OREGON RES BEHAVIORAL INTERVENTION STRAT

ORG_STATE: OR

PHR: Project Narrative The negative impact of maternal depression on the livelihood of families and children cannot be understated, particularly for those living in poverty and marginalized communities who are less likely to receive treatment. We developed a paraprofessional-guided Internet-delivered depression intervention to overcome barriers to service utilization for depressed mothers of young children. Our Phase II SBIR goals serve to significantly expand access to depression intervention within the community by developing a Train-the-Trainer program that will more firmly seat training and intervention delivery in the community, by the community.

PI_NAMEs: DAVIS, BETSY ;FEIL, EDWARD GUSTAV;SMITH, DAVID RANDOLPH (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Adoption;Area;Award;behavioral outcome;Benchmarking;Certification;Characteristics;Child;Child Rearing;commercialization;Communication;Communities;community setting;Depressive disorder;depressive symptoms;Development;Disease remission;Distress;economic disparity;Economics;Educational process of instructing;Effectiveness;effectiveness evaluation;effectiveness/implementation study;effectiveness/implementation trial;efficacious intervention;eHealth;Emotional;Evaluation;evidence base;Evidence based program;experience;Family;Feedback;Funding;Generations;Goals;Head Start Program;high risk;Human;Hybrids;improved;improved outcome;internet delivery;Intervention;intervention delivery;Knowledge;language training;learning strategy;Low income;marginalized community;Marketing;maternal depression;Measures;member;Mental Depression;Modeling;Monitor;Mothers;Outcome;Persons;Phase;poor communities;Population;primary outcome;Process;programs;Progress Reports;prototype;psychologic;Randomized;randomized trial;Reaction Time;recruit;Resource Allocation;rural area;satisfaction;service utilization;Site;skills;Small Business Innovation Research Grant;Spanish/English;Techniques;telecoaching;telephone coaching;Trainers Training;Training;Training Programs;treatment response;Underserved Population;usability;Vulnerable Populations;webinar

PROJECT_TITLE: MomNet: Development of a Coach-Training Program for an Empirically Supported, Guided ehealth Intervention for Depressed Mothers


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative Mitochondria are important in providing energy for the contracting myocyte, but dysfunctional mitochondria can be harmful to the cell and needs to be eliminated by autophagosomes. This project will provide important new insights into the relationship between reduced autophagy and accumulation of defective mitochondria in the cardiac aging process.

PI_NAMEs: GUSTAFSSON, ASA B. (contact)

PROJECT_TERMS: Acceleration;Age;age related;age related changes;age related decline;Age related pathologies;aged;Aging;aging process;Autophagocytosis;Autophagosome;BCL2 gene;Biochemical;Cardiac;cardiac aging;Cardiac health;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;catalase;Cell Aging;Cell Death Induction;Cells;Co-Immunoprecipitations;Complex;Contracts;Data;Degradation Pathway;Development;Disease;experimental study;Fibrosis;Generations;Goals;hallmarks of aging;Heart;Heart Diseases;Heart failure;heart function;Homeostasis;Hypertrophy;Incidence;insight;Intervention;Life Expectancy;Link;Lysosomes;Mediating;middle age;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial permeability transition pore;Molecular;Morphology;Mus;Muscle Cells;myocardial damage;new therapeutic target;old mice;older patient;Organelles;overexpression;Oxidative Stress;Pathway interactions;Predisposition;preservation;Prevalence;prevent;Production;programs;protein aggregation;Proteins;Reactive Oxygen Species;Research;Respiration;Role;Stress;Testing;Time;Tissues;Transgenic Mice;Western Blotting

PROJECT_TITLE: Autophagy and Megamitochondria in Cardiac Aging and Heart Failure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MIM-R(01)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Efficient processing of RNA and translation into proteins requires interactions with numerous RNA binding proteins, and can be regulated by chemical post-transcriptional RNA modifications (PTrMs). We have selected Adenovirus as a model system with which to study RNA modifications on non-coding and messenger RNAs and to determine how they can be harnessed to control cellular processes during infection. The overall goal of this proposal is to develop high-throughput mass spectrometry approaches to quantify PTrMs and identify how they impact association of RNA binding proteins with technologies that will have broad applicability to enable new biology in virus-host interactions and epitranscriptomics.

PI_NAMEs: GARCIA, BENJAMIN A (contact);WEITZMAN, MATTHEW D.

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Address;Adenovirus Infections;Adenoviruses;Affinity;Affinity Chromatography;Amino Acids;Antibodies;base;Binding;Binding Proteins;Biochemical;Biological;Biological Assay;Biological Models;Biological Process;Biology;Cell Nucleus;Cell Physiology;Cells;Cellular biology;Chemicals;combat;Data;Detection;Disease;DNA Viruses;Double Stranded DNA Virus;epitranscriptome;epitranscriptomics;gene product;Genetic;Genetic Transcription;Goals;Growth;Host Defense;Human;human disease;human pathogen;Immune response;Immune system;improved;Individual;Infection;Innate Immune Response;Knowledge;Life;Maps;Mass Spectrum Analysis;Measures;Mediating;Messenger RNA;Methods;Modification;new technology;Nuclear;Nuclear Export;Oligonucleotides;Organ;Pathway interactions;Persons;Physiologic pulse;Post-Transcriptional RNA Processing;posttranscriptional;Process;Production;protein complex;protein expression;Proteins;Proteomics;Reader;Regulation;Respiratory Tract Infections;RNA;RNA analysis;RNA metabolism;RNA Processing;RNA Sequences;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;Role;Stable Isotope Labeling;Study models;System;Technology;Tertiary Protein Structure;Time;tool;Transcript;transcriptome sequencing;Translating;Translations;Untranslated RNA;Viral;Viral Genes;viral RNA;Virus;Virus Diseases;virus host interaction;Virus Replication

PROJECT_TITLE: Viral modulation of epitranscriptomic mechanisms

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative As the burden of neurological disorders and neurodegenerative diseases in the United States and worldwide is high, there is a critical need to discover and perform an initial evaluation of molecular imaging biomarkers and/or biomarker signatures, such as positron emission tomography (PET) imaging tools, to support the clinical development and translation of novel neurotherapeutics. This work will identify, design, and evaluate subtype- selective metabotropic receptor PET ligands to deliver candidate biomarkers for definitive analytical and clinical validation studies, facilitating drug discovery and target engagement study of novel neurotherapeutics.

PI_NAMEs: LIANG, STEVEN H (contact)

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: ABCB1 gene;Affinity;Alzheimer's disease related dementia;Autopsy;Autoradiography;Benchmarking;Binding;Binding Proteins;Biochemical Process;Biodistribution;Biological;Biological Assay;Biological Process;biomarker signature;Blood specimen;Brain;brain tissue;candidate marker;Cells;Central Nervous System Diseases;Characteristics;Chemistry;Clinical;clinical development;clinical translation;Corpus striatum structure;design;Development;Docking;Dose;drug discovery;Drug Targeting;Evaluation;excitotoxicity;Glutamates;Goals;Human;Image;image translation;imaging biomarker;Imaging Device;imaging study;improved;In Vitro;in vivo;in vivo evaluation;kinetic model;Kinetics;Knockout Mice;Knowledge;Label;Lead;Libraries;Ligands;lipophilicity;Liver Microsomes;Measurement;Mediating;metabotropic glutamate receptor 2;Metabotropic Glutamate Receptors;Molecular;molecular imaging;Monitor;mouse model;National Institute of Mental Health;Nervous System Disorder;Neurodegenerative Disorders;Neurons;next generation;nonhuman primate;novel;Parkinson Disease;Penetration;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Physiological;Plasma;Plasma Proteins;Pontine structure;Positron-Emission Tomography;Radiolabeled;radioligand;receptor;Research;response;Rodent;Safety;Selection Criteria;Series;Signal Pathway;Site;Specificity;Testing;Thalamic structure;Therapeutic;Toxic effect;Translations;United States;uptake;Validation;validation studies;Work

PROJECT_TITLE: Subtype-Selective Metabotropic Glutamate Receptor PET Ligands

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Prevention

PHR: PROJECT NARRATIVE Infections due to Staphylococcus aureus pose a major public health threat. In this study, we will define how the “normal” bacterial communities carried on the skin and in the nose may make someone more or less likely to acquire S. aureus. We will also define how topical antimicrobials (often prescribed to prevent S. aureus infection) alter the skin and/or nasal bacterial communities, and discover how these alterations may lead to colonization with harmful or antibiotic-resistant bacteria. This knowledge will help to optimize S. aureus prevention and treatment strategies.

PI_NAMEs: FRITZ, STEPHANIE ANN (contact);WYLIE, KRISTINE M.

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Adult;Adverse effects;Affect;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacterial Antibiotic Resistance;bacterial community;biobank;Biometry;Characteristics;Childhood;Classification;Clinical;Clinical Microbiology;cohort;Combating Antibiotic Resistant Bacteria;commensal microbes;Communities;community setting;comparison control;Computational Biology;Coupled;data integration;Detection;Development;Disease;disorder prevention;Effectiveness;epidemiologic data;Epidemiologic Factors;Epidemiology;Exposure to;Genes;Genetic Determinism;health care settings;high risk;Hospitals;Household;Human;Incidence;Individual;Infection;Infectious Disease Epidemiology;Infectious Skin Diseases;innovation;Intensive Care Units;Intervention;Knowledge;Local Anti-Infective Agents;Measures;Metabolic;Metadata;Metagenomics;methicillin resistant Staphylococcus aureus;microbial community;microbial genomics;microbiota;microorganism;Morbidity - disease rate;mortality;Multi-Drug Resistance;multi-drug resistant pathogen;multidimensional data;multidisciplinary;nasal microbiota;nasal swab;Natural History;Nature;Nose;Outcome;Outpatients;Participant;pathogen;pathogenic microbe;Pathogenicity;Patients;pediatric patients;Phase;Phenotype;Plasmids;Population;post intervention;Predisposition;prevent;Prevention strategy;Preventive measure;Public Health;Randomized;Regimen;repository;Research;Resistance;resistance gene;resistome;Risk;Sampling;Seminal;Shotgun Sequencing;Skin;skin microbiota;Staphylococcus aureus;Staphylococcus aureus infection;Structure;Testing;topical anti-microbial;Topical application;transmission process;treatment strategy;ward

PROJECT_TITLE: Microbial Community Disruption Following Topical Antimicrobial Application in Staphylococcus aureus-Affected Households

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_DEPT: PSYCHIATRY

PHR: Elderly Spanish-English bilinguals at risk for Alzheimer’s disease (AD) are rapidly increasing in numbers in the USA but relatively little is known about how cognitive assessments should be modified to cater to this population. The current proposal aims to establish unique aspects of the presentation of AD in bilinguals while testing theoretical models of bilingual language processing and cognitive decline in AD. The proposed studies will provide important information about the presentation of language impairments in bilinguals with AD, and will develop theoretically motivated cognitive assessment procedures for bilinguals.

PI_NAMEs: GOLLAN, TAMAR  (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: Address;Affect;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Behavioral;bilingualism;Clinical;Cognitive;Cognitive deficits;cognitive function;cognitive system;cognitive task;cognitive testing;Communication;cost;Cues;design;Differential Diagnosis;Early Diagnosis;Elderly;Exhibits;Face;Freedom;Home;human old age (65+);Impaired cognition;improved;Instruction;Language;language impairment;language processing;Latino Population;Linguistics;Maintenance;Managed Competition;Memory;Modeling;Monitor;Names;Nature;Neuropsychology;Patients;Pattern;Performance;performance tests;Population;prevent;Procedures;Production;Psycholinguistics;Reading;Research;semantic processing;Semantics;Series;Spanish/English;Specific qualifier value;Speech;syntax;Testing;Theoretical model;Time;tool;verbal;Work

PROJECT_TITLE: Language Switching with Alzheimer's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Gene Therapy;Genetics;Immunotherapy;Neurodegenerative;Neurosciences

ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative Recent advances in cell therapy with autologous effector T cells engineered to target and destroy tumor cells is leading to extraordinary breakthroughs in cancer treatment. The current proposal seeks to develop new engineered T regulatory cells that modulate inflammation and improve cognitive function in Alzheimer’s Disease. Successful development of this innovative therapeutic strategy will be the foundation of new treatment approaches for patients.

PI_NAMEs: SENTMAN, CHARLES L. (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: abeta accumulation;abeta oligomer;Acceleration;Affect;Age Years;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease therapy;Amyloid beta-Protein;Anti-Inflammatory Agents;Area;Autologous;Behavior;Behavioral;Binding;Brain;cancer therapy;CAR T cell therapy;Cell Therapy;cellular engineering;Central Nervous System;chimeric antigen receptor;Clinic;clinical candidate;Clinical Management;Cognitive;Cognitive deficits;cognitive function;Data;Dementia;Deposition;Development;Disease;effector T cell;engineered T cells;Engineering;Evaluation;Excision;extracellular;family management;Fiber;first-in-human;Foundations;FOXP3 gene;frontal lobe;genetically modified cells;Gliosis;Goals;Hippocampus;Immune;immune modulating agents;Immune response;Immune system;immunoregulation;Impaired cognition;improved;in vivo;Inflammation;Inflammation Mediators;Inflammatory;innovation;Laboratories;Macrophage;manufacture;Mediating;Memory impairment;Microglia;mouse model;Mus;neoplastic cell;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuroinflammation;neuron loss;Neuronal Dysfunction;Neurons;neuroprotection;neurotoxicity;novel;novel therapeutic intervention;novel therapeutics;Patients;Peripheral;pre-clinical;Production;Property;protein aggregation;Proteins;Reaction;Regulatory T-Lymphocyte;Role;Sampling;scale up;Senile Plaques;Site;Specificity;T-Lymphocyte Subsets;tau Proteins;Testing;Therapeutic;Tissues;Toxicity Tests;trafficking

PROJECT_TITLE: Immunomodulatory and behavioral effects of CAR T regulatory cell therapy for Alzheimer's Disease”.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Z(55)R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Hematology;Hodgkin's Disease;Infectious Diseases;Lung;Lymphatic Research;Lymphoma;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE We propose to investigate factors that may contribute to poor outcomes in Hodgkin lymphoma in people living with HIV in South Africa where the difference in outcomes is striking. Present evidence suggests that at least part of the difference in outcomes reflects long delays in Hodgkin lymphoma diagnosis in PLWH. As such, we will develop and test a new diagnostic algorithm based on plasma tumor molecular markers that may expedite the diagnosis of Hodgkin lymphoma in PLWH.

PI_NAMEs: AMBINDER, RICHARD FREDERICK (contact);XIAN, RENA

PROGRAM_OFFICER_NAME: LIDDELL HUPPI, REBECCA

PROJECT_TERMS: Address;AIDS-Related Lymphoma;Algorithms;antiretroviral therapy;Autopsy;Biological Assay;Biopsy;cancer care;Cause of Death;Cessation of life;Characteristics;chemotherapy;Chemotherapy-Oncologic Procedure;Chromosomes;Classification;Clinical;Clinical Trials;co-infection;cohort;Consent;Control Groups;cost;Country;Coupled;Deterioration;Diagnosis;Diagnostic;diagnostic algorithm;Diagnostic Procedure;diagnostic strategy;Disease;Disparity;DNA;Enlargement of lymph nodes;Enrollment;Ensure;Epstein Barr Virus associated tumor;Epstein-Barr Virus-Related Lymphoma;Evaluation;Excision biopsy;experience;Fine needle aspiration biopsy;follow-up;General Population;high risk;Histologic;HIV;HIV Infections;Hodgkin Disease;Hospitals;Human Herpesvirus 4;Immunoglobulins;improved;infection rate;Inferior;information gathering;Infrastructure;Knowledge;Laboratories;Lymphoma;Malignant Neoplasms;Measures;Methylation;minimally invasive;Modernization;Molecular;molecular diagnostics;molecular marker;mortality;Mutation;Newly Diagnosed;novel diagnostics;Observational Study;Odds Ratio;Operative Surgical Procedures;Organ;Outcome;outcome disparities;Participant;Pathologic;Patient Triage;Patients;Pattern;Performance;Performance Status;Persons;Plasma;Population Study;Predictive Value;Prognosis;programs;Progression-Free Survivals;prospective;Reporting;Resources;response;Risk Factors;Role;Somatic Mutation;South Africa;South African;Specificity;Specimen;standard of care;Symptoms;Techniques;Testing;Time;treatment response;Tuberculosis;tuberculosis diagnostics;tuberculosis treatment;tumor;Tumor Markers;tumor progression;Validation

PROJECT_TITLE: Hodgkin Lymphoma in PLWH in South Africa: TB, EBV, and Tumor Molecular Markers


NIH_SPENDING_CATS: Immunotherapy

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Defining STIM1 function at the Immunological Synapse – NARRATIVE STIM1-dependent Ca2+ signals represent the primary means of Ca2+ entry in T cells and are required for adaptive immunity. An immunological synapse is a temporary interaction between T cells and antigen-presenting cells and leads to a profound re-organization of multiple signaling proteins within the T cell. The current proposal focuses on defining the underlying mechanisms controlling localization of proteins at the immunological synapse and determining their impact on T cell activation.

PI_NAMEs: SOBOLOFF, JONATHAN A (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: adaptive immunity;Adoptive Transfer;Affect;Antigen-Presenting Cells;ATP phosphohydrolase;Autoimmune Diseases;Automobile Driving;Bone Marrow;CD8-Positive T-Lymphocytes;Cell membrane;cell transformation;Cells;Cellular biology;Charge;Complex;confocal imaging;Confocal Microscopy;CRISPR/Cas technology;cytokine;defined contribution;design;Effector Cell;effector T cell;Endoplasmic Reticulum;Event;Exhibits;experimental study;Failure;Family;Fluorescence Microscopy;Generations;GTP Binding;Guanosine Triphosphate Phosphohydrolases;Immune response;immunological synapse;immunological synapse formation;Immunology;insight;Investigation;Link;Mediating;Membrane Potentials;Metabolic;Metabolism;Mitochondria;mutant;Mutation;Nature;novel;Oxygen Consumption;Phosphatidylinositols;Phospholipase C;Physiological;Process;Production;Proteins;Protocols documentation;Reporting;Rest;Role;sensor;Series;Signal Transduction;Signaling Protein;Site;Site-Directed Mutagenesis;STIM1 gene;Superoxides;T cell differentiation;T-Cell Activation;T-Lymphocyte;tool;Transfection;Translations;tumor immunology;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(02)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Autoimmune Disease;Immunotherapy

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The thymus mediates T cell positive and negative selection to prevent autoimmunity. Migratory and resident antigen presenting cells contribute to thymocyte selection by diverse, sometimes cell specific mechanisms. Our understanding on the emergence of autoimmune pathologies driven by autoreactive T cells who escape tolerance mechanisms, such as central tolerance, is still limited.

PI_NAMEs: OROZCO FIGUEROA, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Affinity;anergy;Antigen Presentation;Antigen-Presenting Cells;Antigens;Apoptosis;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Process;Autoimmunity;autoreactive T cell;autoreactivity;B-Lymphocytes;CD4 Positive T Lymphocytes;cell motility;cell type;Cells;central tolerance;chemokine receptor;Clonal Deletion;Clone Cells;Coculture Techniques;Complex;CX3CL1 gene;Data;Dendrites;Dendritic Cells;Development;Education;Family;FOXP3 gene;Fractalkine;Gene Rearrangement;Genetic Transcription;Goals;Human;Immune;In Situ;In Vitro;Insulin;Knowledge;Ligands;Location;Lymphocyte;Macrophage;Mediating;microbiome;migration;Molecular;monocyte;Mononuclear;mouse model;Mus;Nature;neglect;Organ;Outcome;Pathology;Peptide/MHC Complex;Peptides;Peripheral;Phagocytes;Population;prevent;primary lymphoid organ;Process;Proliferating;Reaction;Regulatory T-Lymphocyte;Reporting;response;Role;Shapes;Signal Transduction;Site;spatiotemporal;Structure;Structure of thymic cortex;Structure of thymic medulla;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Thymic epithelial cell;thymocyte;Thymocyte Development;Thymocyte Selection;Thymus Gland;Tissues;tool;transcription factor;Work

PROJECT_TITLE: The role of CX3CR1+ antigen presenting cells in T cell selection and central tolerance"

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07-U(20)L]