NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Neurosciences;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD)

PHR: Narrative Previous evidence regarding the efficacy of photobiomodulation (PBM) in the treatment of temporomandibular disorder (TMD) is inconclusive due to methodological weaknesses. Our goal is to conduct a rigorous, double- blind, sham-controlled, randomized clinical trial of multimodal PBM therapy for pain related to TMD. Also, we propose to determine if PBM-induced changes in pain sensitivity and inflammation contribute to PBM’s analgesic effects.

PI_NAMEs: FILLINGIM, ROGER B;RIBEIRO-DASILVA, MARGARETE C (contact)

PROGRAM_OFFICER_NAME: FISCHER, DENA

PROJECT_TERMS: Adult;Advertisements;Affect;Aftercare;Age;Analgesics;analog;Antiinflammatory Effect;Arthralgia;Biological;Blood;Blood flow;cartilage regeneration;Chronic;Chronic disabling pain;chronic painful condition;Clinical;clinical examination;clinical pain;Clinical Trials;common treatment;Communities;comparison group;Complex;Computer Assisted;craniofacial;cytokine;Development;diagnostic criteria;Dose;Dose Rate;Double-Blind Method;Drug Prescriptions;effective therapy;Effectiveness;efficacy evaluation;eligible participant;Evidence based treatment;Exclusion;experience;Face;follow-up;Goals;Health Care Costs;Heterogeneity;improved;Inflammation;Inflammatory;Inflammatory Response;Informed Consent;Injection of therapeutic agent;Injections;injured;inpatient psychiatric treatment;interest;Internet;Jaw;Lasers;Lymphatic function;Mechanics;Mediating;Medical History;Meta-Analysis;Methodology;Modality;Morbidity - disease rate;multimodality;Musculoskeletal Diseases;Musculoskeletal Pain;Myalgia;Myofascial Pain Syndromes;Neural Pathways;Nociception;Nonpharmacologic Therapy;Operative Surgical Procedures;Opioid;orofacial;Orthodontic;Pain;Pain intensity;Pain management;pain sensitivity;Pain Threshold;Participant;Pathway interactions;patient population;Patients;Peripheral;Persons;photobiomodulation;Phototherapy;Placebos;Population;Pre-Clinical Model;pressure;primary outcome;Protocols documentation;Quality of life;Randomized;Randomized Controlled Clinical Trials;Recommendation;Recording of previous events;recruit;Reporting;Research Design;response;Schedule;screening;secondary outcome;side effect;Site;Spinal Cord;Steroids;symptomatology;System;Telephone;Temporomandibular joint disorder pain;Temporomandibular Joint Disorders;Testing;Therapeutic;Therapeutic Effect;TMD treatment;Trauma;treatment effect;Treatment Efficacy;Treatment outcome;treatment response;trial design;Trigeminal Nuclei;trigger point;Visit;Visual

PROJECT_TITLE: Photobiomodulation for the management of Temporomandibular disorder pain


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Prevention;Stroke

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Stroke prevention guidelines state that “an ideal stroke risk assessment tool that is simple, is widely applicable and accepted, and takes into account the effects of multiple risk factors does not exist.” We propose to address this gap by aggregating and harmonizing existing patient-level data collected as part of longitudinal cohort studies supported by the NINDS and NHLBI. We will extend the advanced machine learning techniques developed as part of our currently funded NIH BD2K award to develop and validate new risk prediction models for stroke and compare their performance to existing and simpler tools.

PI_NAMEs: PENCINA, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Address;Age;Alabama;Algorithms;American Heart Association;American Stroke Association;Assessment tool;Award;Big Data to Knowledge;Categories;Cause of Death;cohort;Cohort Studies;Complex Analysis;computing resources;Data;data exchange;data harmonization;database of Genotypes and Phenotypes;deep learning;design;Development;Ethnic Origin;Ethnic Population;Etiology;Event;experience;Funding;genetic information;Geography;Guidelines;Hemorrhage;Individual;Ischemia;Longitudinal cohort study;Machine Learning;Methods;Modeling;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;offspring;Outcome;Patient Self-Report;Patients;Performance;precision medicine;predictive modeling;predictive tools;Prevention Guidelines;Prevention strategy;Primary Prevention;racial population;Recommendation;repository;Research;Risk Assessment;Risk Estimate;Risk Factors;risk prediction;risk prediction model;risk stratification;sex;Stroke;stroke model;Stroke prevention;stroke risk;Techniques;Time;tool;United States National Institutes of Health;Universities;Update;Validation;web services

PROJECT_TITLE: Data Harmonization


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF EDUCATION

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Pediatric

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Considerable advancements have been made in the field of molecular biology by combining the knowledge base of multiple scientific disciplines in order to understand the structure, function, and relationships between nucleic acids and proteins. The overall goal of the SHaping of Authentic Practices by Engaging in Modeling of A Topic with Teachers to Explore Research in Science (SHAPE MATTERS) project is to engage high school biology and chemistry teachers in a rigorous professional development experience that will enable them to incorporate some of these advancements into their curriculum. From this, secondary science curriculum will be developed that is centered on authentic scientific practices, and the secondary students will showcase their learning with 3-D models and molecular stories in a community-based symposium event.

PI_NAMEs: BOAL, AMIE K;HILL, KATHLEEN M (contact);ROPSON, IRA J;YENNAWAR, HEMANT P.;YENNAWAR, NEELA H.

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: 3-Dimensional;Biological;Biology;career;Chemistry;classroom research;college;Communities;Data;design;Development;disadvantaged student;Discipline;diversity and equity;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Engineering;Evaluation;Event;experience;Explosion;faculty support;Future;Goals;Health;high school;High School Faculty;High School Student;Human;interest;Interview;Investments;Journals;K-12 Faculty;Knowledge;knowledge base;Learning;Life;Magnolia;Manuscripts;Measures;Medicine;meetings;Mentors;Methods;Modeling;Molecular;Molecular Biology;Morphologic artifacts;multidisciplinary;Nature;Next Generation Science Standards;Nucleic Acids;Outcome;Pennsylvania;Perception;Population Heterogeneity;Program Evaluation;Program Reviews;programs;Proteins;Questionnaires;Records;Report (document);Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Sampling;school district;Schools;Science;science education;science teacher;Scientist;Secondary Schools;Secondary to;Series;Shapes;skills;socioeconomics;Structure;Structure-Activity Relationship;student participation;Students;Surveys;symposium;System;teacher;Teaching Method;Thinking;three-dimensional modeling;treatment group;web site;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


ADMINISTERING_IC: CA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE Several blood cancers arise during aging (including myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML)) in a process that progressively alters adult blood-forming stem cells. Molecular alterations that separate healthy aged stem cells from stem cells developing cancer, are vastly unknown, but hold the key for curative therapies. We will be the first to investigate the contribution of a highly specific form of autophagy (“self- eating”), which is the cells’ waste and recycling system, to blood cancer formation and therapy resistance. Our study may provide a new therapeutic avenue for patients with MDS and AML, and potentially a paradigm for other currently incurable stem cell-derived cancers.

PI_NAMEs: WILL, BRITTA  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Ablation;Acute Myelocytic Leukemia;Adopted;Adult;adult stem cell;Age related pathologies;aged;Aging;aging process;aging related;Amino Acids;Autophagocytosis;Azacitidine;BCL1 Oncogene;biological adaptation to stress;Biology;Biosensor;Blast Cell;cancer stem cell;Cell Compartmentation;Cell Maintenance;cell type;Cells;Cellular Stress;Chronic stress;clinically relevant;Clonal Evolution;Coenzyme A;curative treatments;Cysteine;Data;Degradation Pathway;Development;Disease;Dose;Dysmyelopoietic Syndromes;Eating;Elderly;Epigenetic Process;Evolution;Exposure to;fatty acid metabolism;Fatty Acids;Gene Expression;Generations;Genes;Genetic;Genetic Models;Glycolysis;healthy aging;Hematologic Neoplasms;Hematopoiesis;Hematopoietic Neoplasms;Hematopoietic stem cells;Human;Human Cell Line;human model;human old age (65+);Impairment;improved;inhibitor;innovation;insight;Knowledge;Lesion;leukemic stem cell;leukemogenesis;Licensing;lysosomal proteins;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;MLL-rearranged leukemia;Modeling;Molecular;Molecular Chaperones;Molecular Profiling;mortality;mouse model;Multipotent Stem Cells;Mus;Myeloproliferative disease;novel;novel therapeutic intervention;novel therapeutics;older patient;Pathway interactions;Patients;Pattern;Phase;Preleukemia;premalignant;Process;Production;programs;Proteins;receptor;Recurrent disease;Recycling;regenerative;Regulation;Reporter;Resistance;response;Role;Starvation;stem cell aging;stem cell function;stem cells;Stress;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;Tissues;transcriptomics;Translating;Up-Regulation;Variant;wasting;Work

PROJECT_TITLE: Identification and targeting of pathways separating healthy stem cell aging from malignant transformation

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cancer;Contraception/Reproduction;Diabetes;Infertility;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: SYRACUSE

ORG_DEPT: BIOLOGY

ORG_NAME: SYRACUSE UNIVERSITY

PHR: PROJECT NARRATIVE The pool of primordial follicles present at birth represents the total population of oocytes available to a female during her entire reproductive life. Research proposed in this application will elucidate insulin signaling mechanisms regulating primordial folllicle formation. This research will make a fundamental contribution to the understanding of the establishment of the primordial follicle pool and shed light on female reproductive issues such as primary ovarian insufficiency, reproductive aging, menopause, and ovarian cancer.

PI_NAMEs: PEPLING, MELISSA E (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Affect;Biology;Birth;cell motility;Cells;Confocal Microscopy;Cyst;Data;design;Development;diabetic;Diplotene Stage;Embryonic Development;Female;female fertility;Female infertility;Foundations;Future;Genetic;Germ Cells;Germ Lines;Gestational Diabetes;Goals;Gonadal structure;Grant;granulosa cell;idiopathic infertility;Immunohistochemistry;improved;Individual;Infertility;Insulin;Insulin Receptor;insulin signaling;Invertebrates;Knowledge;Life;Malignant neoplasm of ovary;Mammals;Maternal Health;Meiosis;Meiotic Prophase I;Menopause;Molecular;Molecular Target;mouse model;Mus;novel;offspring;Oocytes;Oogonia;Organ Culture Techniques;Ovarian;ovarian dysfunction;Ovarian Dysgerminoma;ovarian reserve;Ovary;Pathway interactions;Phase;Phosphatidylinositols;Phosphotransferases;Population;premature;primary ovarian insufficiency;Primordial Follicle;Process;Publishing;Quality Control;Receptor Protein-Tyrosine Kinases;Regulation;Repression;Reproduction;reproductive;Reproductive History;reproductive senescence;reproductive system disorder;Research;Role;Signal Transduction;Signal Transduction Pathway;Structure of primordial sex cell;Techniques;Testing;therapy development;Time;Vertebrates;Work

PROJECT_TITLE: Molecular Mechanisms regulating Primordial Follicle Formation

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: Columbus

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE This project aims to develop a photoelectrochemistry-enabled multi-utility LOC system for sensing and actuation, namely the “optoelectronic micro-gadget” (OMG). The study will pioneer a design, simulation, implementation, and validation of a mechanically flexible photoelectrode paired with an intensity-modulated illumination source to generate photocurrents for probing and manipulating the local environment in the biosystem at a cellular or sub-cellular dimension scale. The proposed research is relevant to public health because the envisioned system could enable bi-directional engineering technologies in biomedical investigation with minimized resources, improved efficiency, customizable operational modalities, and enhanced opportunities.

PI_NAMEs: LI, JINGHUA  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TITLE: Optoeletronic Micro-Gadget (OMG): a Photoelectrochemistry-Enabled Multi-Utility Lab-on-a-Chip System for Precise and Localized Sensing and Actuation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (82)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Nanotechnology;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

ORG_STATE: MA

PHR: Narrative  Severe muscle injury such as volumetric muscle loss (VML) can greatly compromise physical function and quality of life. This project aims to develop a novel piezoelectric scaffold that can actively recruit endogenous muscle cells by generating electrical signals upon ultrasound stimulation. Both in vitro and in vivo studies have been designed to evaluate the ability of ultrasound-stimulated piezoelectric scaffolds to restore muscle function following VML injuries and to provide insights into future bioactive tissue scaffold design.

PI_NAMEs: WANG, KAI  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;angiogenesis;Animal Model;Animals;Autologous Transplantation;Biochemical;Biocompatible Materials;biomaterial compatibility;Biomedical Engineering;bioscaffold;bone;Boron;Breathing;cardiac regeneration;Cartilage;Cell Adhesion;cell motility;Cells;Clinical;comparison control;cost effective;Cues;Data;design;Development;differentiation in vitro;Engineering;Engraftment;Excision;Exercise;experimental group;Female;Fibrin;Fibrosis;Frequencies;functional improvement;functional mimics;Future;Goals;Histologic;hydrogel scaffold;Hydrogels;immunogenicity;Implant;implantation;improved;In Situ;In Vitro;in vivo;Infection;Infiltration;Injury;injury and repair;insight;male;mechanical stimulus;migration;Minor;Modeling;Morbidity - disease rate;mouse model;Mus;Muscle;Muscle Cells;Muscle Contraction;Muscle function;muscle progenitor cell;muscle regeneration;Muscular Atrophy;myogenesis;Nanotubes;Natural regeneration;Nerve;nerve supply;neurogenesis;novel;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Physical Function;physical impairment;Physical Rehabilitation;physically handicapped;Physiological;Proliferating;Protocols documentation;Quality of life;Recovery;Recovery of Function;recruit;Recruitment Activity;regenerative;repaired;Research Personnel;Role;scaffold;Science;severe injury;sex;sex as a biological variable;Signal Transduction;Site;Skeletal Muscle;Skin;skin regeneration;Source;stem cell differentiation;stem cells;Structure;Technology;Tendon structure;Testing;three dimensional cell culture;Time;tissue regeneration;tissue support frame;Tissues;Traumatic injury;tumor;ultrasound;Vascularization;volumetric muscle loss;Work

PROJECT_TITLE: Piezoelectric bioscaffold for the treatment of volumetric muscle loss

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: We have identified a novel PLCG2 splice variant that is increased in human brain by a polymorphism that is associated with the risk of Alzheimer’s disease. In this proposal, we will confirm these preliminary findings, test whether the PLCG2 isoform generates a stable and functional PLCG2 protein, and identify splicing modulators that improve PLCG2 splicing to reduce AD risk. Overall, this proposal will provide quantitative insights into PLCG2 expression relative to AD risk, test the role of splicing in PLCG2, and begin to translate our findings into a potential pharmacologic approach.

PI_NAMEs: ESTUS, STEVEN  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Address;Affect;aging brain;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease risk;Binding;Biological Assay;Brain;drug development;Exons;Genetic;Genetic Diseases;Genetic Polymorphism;genetic variant;genome wide association study;Human;improved;in silico;Inherited;insight;knock-down;Knowledge;Length;loss of function;Mediating;Molecular;Mutation;neuropathology;novel;Pathway interactions;pharmacologic;Phospholipase;PLCG2 gene;Population;protein expression;protein function;Protein Isoforms;Proteins;prototype;receptor;Receptor Signaling;Risk Factors;RNA;RNA Decay;RNA Splicing;Role;Sampling;Signal Transduction;success;targeted agent;Testing;Translating;TREM2 gene;Variant;Work

PROJECT_TITLE: Deciphering genetics of PLCG2 alternative splicing to understand AD risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: BLACKSBURG

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative  Brucella spp. are bacteria that cause a debilitating, flu-like disease in humans, and these bacteria are classified as Select Agents due to their potential use as biological weapons. Currently, no safe and effective vaccine exists to protect against human Brucella infection. The proposed research will define a quorum sensing pathway in Brucella that may be targeted for vaccine and/or therapeutic development.

PI_NAMEs: CASWELL, CLAYTON C (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: abortion;Anabolism;Animal Model;Animals;Antibiotic Therapy;Antibiotics;Attenuated;Bacteria;bacteria classification;Bacterial Physiology;Biochemical;Biology;bioweapon;Brucella;Brucella abortus;Brucellosis;Carbon;Cell model;Cells;Chemicals;Chronic;combat;Communication;Data;deaf;design;Development;Disease;Domestic Animals;Elements;Enzymes;exposed human population;Exposure to;Family;flu;Future;Gene Expression Profile;Genes;Genetic;genetic element;Genetic Transcription;Genome;Genomic Library;Glean;Goals;Gram-Negative Bacteria;Hearing;homoserine lactone;host colonization;Human;Immune;Individual;Infection;Kinetics;Laboratories;Life Style;Macrophage;Mediator;Modeling;Mus;Mutagenesis;mutant;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;novel vaccines;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Persons;Phenotype;Population;Procedures;Production;programs;Proteins;quorum sensing;Recurrent disease;Regulation;Regulatory Pathway;Relapse;Reporter;Reporting;Research;response;screening;Sterility;System;Testing;Therapeutic;therapeutic development;Transcription Regulatory Protein;transcriptome;Treatment Protocols;vaccine development;vaccine strategy;Vaccines;Vacuole;Virulence;Wild Animals;Work

PROJECT_TITLE: Defining the atypical quorum sensing system of Brucella spp.

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Clinical Research;Pediatric;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative  The neglect of children and adolescents is prevalent and imperils health and well-being throughout the lifespan. This project involves the careful conceptualization, development, and initial validation of a multidimensional youth self-reported measure of adolescent neglect, conceptualized as unmet adolescent needs (versus parental omission). The measure will make it possible for future research to rigorously study adolescent neglect and will provide the necessary conceptual foundation for effective intervention.

PI_NAMEs: KOBULSKY, JULIA  (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: 17 year old;abuse neglect;Address;Adolescence;Adolescent;Adolescent Development;Affect;Age;Area;Attention;Behavior;Benign;Caregivers;Caring;Child;Child Development;child neglect;child protective service;Cognitive;community intervention;Complex;Consensus;contextual factors;Development;Dimensions;Education;effective intervention;Emotional;Ensure;Etiology;Family;Foundations;Future;Generations;Goals;Health;Impaired health;improved;Incidence;Information Systems;instrument;Intervention;Interview;Knowledge;life span;Longitudinal Studies;maltreatment;Measurement;Measures;Medical;neglect;novel;Outcome;Outcome Measure;Parents;Patient Outcomes Assessments;Patient Self-Report;Personal Satisfaction;Philadelphia;pilot test;Policies;Poverty;prevent;Property;Psychometrics;Qualitative Methods;Reporting;Research;Research Project Grants;Research Support;response;Review Literature;Risk;Safety;Sampling;Scholarship;Science;sex;Shelter facility;social;social health determinants;sound;stem;Structure;Supervision;Testing;therapy development;Typology;United States;Validation;Validity and Reliability;Work;Youth

PROJECT_TITLE: A New Foundation: Advancing Adolescent Neglect Science through Measurement Development

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: STONY BROOK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative Public Health Relevance: The proposed research project will explore the utility of terahertz time-domain spectroscopic imaging to measure and map corneal hydration gradients. Patients afflicted with several corneal diseases experience perturbation to corneal hydration levels and its opacity, which in turn can impact vision acuity. Early detection and monitoring of such diseases is key to successful treatment, yet the sensitivity and specificity of clinical techniques are insufficient to provide diagnosis at the early stages.

PI_NAMEs: ARBAB, M. HASSAN  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;Affect;African American;Anesthesia procedures;animal imaging;anterior chamber;Aqueous Humor;Asian;Blindness;Blurred vision;Calibration;Cell Density;Chronic;Clinical;clinical diagnostics;Collagen Fibril;Compensation;Contact Lenses;Cornea;Corneal Diseases;Corneal edema;Corneal Endothelium;Degenerative Disorder;Descemet's membrane;design;detector;Devices;Diagnosis;Diagnostic;Diagnostic Procedure;Diffusion;Disease;disease model;Dryness;Early Diagnosis;Edema;Elderly;Endothelium;Environment;Evaluation;experience;Experimental Models;experimental study;Eye;eye chamber;Fuchs' Endothelial Dystrophy;Glaucoma;Gold;Head;Health;high risk;Hispanic;Histologic;Hydration status;Hydrogels;Image;imaging modality;Imaging Techniques;in vivo;in vivo Model;Injections;instrument;interpatient variability;Keratoconus;Keratoplasty;lens;Light;light scattering;Liquid substance;Maps;Measurement;Measures;Methodology;Modality;Modeling;Monitor;Names;Needles;novel;Operative Surgical Procedures;Optics;Oryctolagus cuniculus;Patients;Performance;Peripheral;Persons;Physiologic Intraocular Pressure;Population;Pressure Transducers;Primary Open Angle Glaucoma;Procedures;public health relevance;Raman Spectrum Analysis;Reaction Time;Reporting;Research;Research Project Grants;Resolution;response;Retina;Risk Factors;ROC Curve;Rotation;Sampling;Scanning;Sensitivity and Specificity;Source;spectroscopic imaging;Spectrum Analysis;Surface;System;Techniques;Testing;Thick;Time;Tissues;tool;Transplantation Surgery;Unconscious State;United States;Vision;Water;Work;World Health Organization

PROJECT_TITLE: Terahertz time-domain spectroscopic imaging of cornea for three dimensional mapping of hydration gradients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pancreatic Cancer;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: African Americans bear a disproportionate brunt of pancreatic cancer (PDAC) and both the incidence and mortality of PDAC are higher amongst them. Better understanding of the causes of these disparities will help develop novel strategies to address them and thus achieve racial health equality. In the current grant proposal, we will evaluate the differences in the mutational and transcriptional landscape between the PDAC in African American and Caucasians and will evaluate the contribution these differences to the disparities in pancreatic cancer incidence and outcomes between African Americans and Caucasians.

PI_NAMEs: DUDEJA, VIKAS  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Address;Adjuvant;Affect;African American;African American population;Age;Algorithms;Applications Grants;caucasian American;Caucasians;CDKN2A gene;Cells;chemotherapy;Clinical;clinically relevant;cohort;Colon Carcinoma;Data;Development;Diagnosis;Diagnostic;Disease;Disparity;epidemiology study;Etiology;exome sequencing;Gene Expression Profile;Gene Expression Profiling;Genes;genetic analysis;genetic signature;Genetic Transcription;Genomics;Goals;health equality;histological specimens;Incidence;insight;KRAS2 gene;KRASG12D;MADH4 gene;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Modality;Molecular;molecular subtypes;mortality;Mutation;Neoplasm Metastasis;new therapeutic target;novel;novel strategies;Obesity;Outcome;outcome disparities;Pancreas;Pancreatic Adenocarcinoma;Pathogenicity;Pathway Analysis;Pathway interactions;Patients;Population;predicting response;Prevalence;programs;Publishing;Race;racial disparity;racial health disparity;Resected;response;Risk;Risk Factors;Sampling;Shapes;Smoking;Specimen;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;Time;TP53 gene;transcriptome sequencing;transcriptomics;treatment response;treatment strategy;tumor;tumor growth;Tumor stage;Tumor Subtype;Variant;Work

PROJECT_TITLE: Integrated Genomic-Transcriptomic Characterization to Identify Molecular Mechanisms of Disparities in PDAC Outcomes

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Opioids;Substance Misuse

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: NARRATIVE KOR is an opioid receptor that signals through canonical second messenger pathways (cAMP inhibition) as well as -arrestin. The goal of this proposal is to examine a new major pathway activated by KOR and to prove its essential role in KOR-induced anti-pruritic effect. The results of the project will increase the current knowledge of opioid signaling and role in prutitus.

PI_NAMEs: BRAILOIU, EUGEN ;INAN, SAADET  (contact)

PROGRAM_OFFICER_NAME: LE, HOANG VAN

PROJECT_TERMS: Acute;Affinity;Agonist;Amino Acid Motifs;Amino Acids;antagonist;Antipruritic Effect;Arrestins;Back;Behavior;beta-arrestin;Binding;C-terminal;Chloroquine;Choline;chronic itch;Chronic Kidney Failure;Clinic;Clinical Research;Complex;Couples;Cyclic AMP;Cyclic GMP;Data;Development;Dose;drug development;Experimental Designs;FDA approved;FRAP1 gene;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Goals;GTP Binding;GTP-Binding Protein alpha Subunits, Gs;Guanine Nucleotide Exchange Factors;Image;image visualization;Impairment;In Vitro;in vivo;interdisciplinary approach;Investigation;Japan;kappa opioid receptors;Knowledge;Laboratories;Ligands;Measurement;Mediating;Modeling;Molecular;Monomeric GTP-Binding Proteins;Mus;Mutation;Nalbuphine;Neck;Neurons;Opioid;Opioid agonist;Opioid Receptor;Pathway interactions;Pentazocine;Peripheral;pharmacologic;Pharmacology;Phosphatidic Acid;Phospholipase C;Phospholipase D;Physiology;Play;preclinical study;Production;Protein C;Protein Kinase C;Proteins;prototype;Pruritus;receptor;Receptor Activation;Receptor Mediated Signal Transduction;Receptor Signaling;Reporting;response;rho GTP-Binding Proteins;Role;Second Messenger Systems;sigma-1 receptor;Signal Induction;Signal Pathway;Signal Transduction;skin disorder;Solid;Spinal Cord;Structural Protein;Systemic disease;Tail;Techniques;Tertiary Protein Structure;Testing;transcription factor;Work

PROJECT_TITLE: Deciphering the complex pharmacology of kappa opioid receptor: Towards the understanding of a third signaling pathway and its essential role in antipruritic effect

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative This proposal aims to understand the control mechanism underlying functional dynamics using cutting-edge manifold, control theory, and machine learning technologies. We will first develop a novel deep model to learn the system dynamics from the time-evolving functional connectomes. After that, we will apply the new computational model to the existing human connectomes to elucidate the relationship between the control mechanism of functional dynamics and cognitive functions.

PI_NAMEs: WU, GUORONG  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Animals;autoencoder;Behavior;Biological;Brain;brain control;Brain region;Characteristics;Cognition;Cognitive;cognitive control;cognitive function;Collection;Complex;complex biological systems;Computer Models;Computer software;computerized tools;connectome;connectome data;control theory;Data;Data Science;Decision Making;deep learning model;Disease;Dissection;dynamic system;Early identification;early psychosis;Engineering;Equation;Evolution;Fiber;flexibility;Frequencies;Functional Magnetic Resonance Imaging;Goals;high dimensionality;Human;Human Characteristics;human data;imaging biomarker;Individual;information processing;innovation;insight;interest;Language;Learning;lens;Light;Linear Models;Link;Machine Learning;machine learning model;Mathematics;Measurement;Measures;Mechanics;mental state;method development;Mind;Modeling;Nature;neural;neural circuit;neural network;Neurodegenerative Disorders;neuroimaging;Neurons;Neurosciences;Nonlinear Dynamics;novel;operation;optogenetics;Outcome;Pattern;Prevalence;Process;Research;response;Rest;Science;secondary analysis;self organization;Series;Short-Term Memory;simulation;success;System;Technology;Thinking;Time;Training;vector;Verbal Auditory Hallucinations;Vertebral column;Visual;white matter;Work

PROJECT_TITLE: Understanding Mechanism of Functional Dynamics Through An Explainable Neural Network Landscape with Geometric Control

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

PHR: Project narrative: Fentanyl and fentanyl analogs are involved in more than half of all drug overdose deaths, a statistic that has continued to rise over the last decade. However, the molecular mechanisms of neuroadaptations induced by such potent synthetic opioids are vastly understudied in the addiction field. This proposal will address that critical barrier by providing insight into both the immediate and long-lasting molecular consequences of fentanyl exposure on brain microRNA pathways and blood microRNA expression for biomarker analysis.

PI_NAMEs: DAWS, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Abstinence;Acute;addiction;Agonist;analog;antinociception;Arrestins;Basic Science;Behavior;Binding;Biological Markers;Blood;Blood specimen;blood-brain barrier crossing;Brain;Brain region;cell immortalization;Cell Line;Cells;Cessation of life;comparative;craving;Cues;Data;Data Set;dosage;Dose;Drug Exposure;Drug Regulations;drug seeking behavior;Epidemic;epigenomics;exosome;Fentanyl;fentanyl analog;fentanyl exposure;fentanyl overdose;fentanyl seeking;fentanyl self-administration;fentanyl use;Gene Expression;Heroin;Heroin Dependence;human subject;insight;interest;Investigation;Length;Link;lipophilicity;Literature;Measures;Mediating;Messenger RNA;microRNA biomarkers;MicroRNAs;miRNA expression profiling;Mitogen-Activated Protein Kinases;Modeling;Modification;Molecular;Morphine;mu opioid receptors;Naloxone;National Institute of Drug Abuse;Nature;neuroadaptation;Neurobiology;neurochemistry;Neurons;neurophysiology;Opioid;Opioid agonist;opioid epidemic;opioid overdose;opioid use;Outcome Study;overdose death;Pathway interactions;Patient Care;Pattern;peripheral blood;Pharmaceutical Preparations;Pharmacology;prescription opioid;Protein Inhibition;Proteins;Rattus;Recovery;Regulation;Regulatory Pathway;Relapse;Reporting;Repression;response;Rodent Model;Self Administration;Serum;Signal Induction;Signal Pathway;Signal Transduction;Signaling Molecule;Small RNA;statistics;substance use;synthetic opioid;Testing;Therapeutic Intervention;Time;Tissues;transcriptome sequencing;translational potential;Translations;treatment response;United States;Untranslated RNA;Vertebral column

PROJECT_TITLE: Delineation of microRNA regulatory pathways that support fentanyl-seeking behavior

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE While replicating in human red blood cells, the malaria parasite Plasmodium falciparum scavenges fatty acids from the host’s plasma. This project will develop fatty acid alkynes as sensitive probes of parasite fatty acid acquisition. These probes will be used to better understand the roles of key acyl-CoA synthetases and the effects of their inhibitors.

PI_NAMEs: KLEMBA, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acceleration;Acyl Coenzyme A;Alkynes;Anti-malarial drug resistance;Anti-malarials;asexual;Biological Assay;Cell membrane;Cessation of life;Clinical;Coenzyme A;Coenzyme A Ligases;Dependence;Development;Diffusion;drug development;drug discovery;Enzymes;Erythrocytes;Family;fatty acid analog;fatty acid metabolism;Fatty Acids;Generations;Human;inhibitor;insight;knock-down;Label;Lecithin;lipid biosynthesis;Lipids;Malaria;Mediating;Metabolic;Metabolic Pathway;Mutation;novel;novel strategies;Parasites;Pathogenicity;Phase I Clinical Trials;Phosphatidylethanolamine;Phospholipids;Physiological;Plasma;Plasmodium falciparum;Play;Positioning Attribute;Public Health;Reaction;Resistance;resistance mechanism;Role;Source;Specificity;Testing;thioester;tool;Triglycerides;Unsaturated Fatty Acids;uptake

PROJECT_TITLE: Profiling malarial lipid biosynthesis and key acyl-coenzyme A synthetase activities with fatty acid alkynes

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Orphan Drug;Osteogenesis Imperfecta;Pediatric;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: CITY COLLEGE OF NEW YORK

PHR: Project Narrative Osteogenesis imperfecta is a rare disease related to defects in collagen type I - the most abundant component of bone - that are caused by mutations in several genes, including TMEM38B encoding TRIC-B, a potassium channel present in the membrane of the endoplasmic reticulum, the intracellular organelle where collagen type I is synthesized. Little is known about the skeletal consequences of mutations in TRIC-B and no cure is available for osteogenesis imperfecta. In this project we aim to clarify the effect of mutant TRIC-B in the function of the osteoblasts, the bone forming cells, and on bone fragility to identify a target for therapy.

PI_NAMEs: CARRIERO, ALESSANDRA  (contact);FORLINO, ANTONELLA

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Actins;Address;Adhesions;Affect;Age;Animal Model;beta catenin;Biochemical;Biological;Biology;Biomechanics;Birth;bone;bone cell;Bone Diseases;bone fragility;bone geometry;bone mass;Bone Matrix;bone strength;Bone Tissue;Ca(2+)-Calmodulin Dependent Protein Kinase;Cadherins;Calcium;Calcium-Binding Proteins;Calmodulin-Binding Proteins;Calvaria;Carbonates;Cations;Cell Adhesion;Cell membrane;Cell Physiology;Cell-Cell Adhesion;Cells;Clinical;Collagen Fiber;Collagen Type I;Complex;Confocal Microscopy;crystallinity;Cytoplasmic Tail;Cytoskeleton;Cytosol;Data;Defect;Deformity;Development;Disease;druggable target;E-Cadherin;efficacy evaluation;Endoplasmic Reticulum;Environment;extracellular;Extracellular Matrix;Femur;Fracture;Future;Gene Expression;Generations;Genes;Genetic Diseases;Goals;Health;Heritability;high resolution imaging;Human;Imaging Techniques;Impairment;In Vitro;inorganic phosphate;insight;Integral Membrane Protein;Investigation;Ions;Knock-out;Knockout Mice;Ligands;Link;loss of function;loss of function mutation;Maintenance;Measures;Mechanics;Membrane;microCT;Microscopy;Minerals;Molecular;mouse model;multidisciplinary;Mus;mutant;Mutant Strains Mice;Mutation;new therapeutic target;Newborn Infant;notch protein;Nuclear Protein;Nuclear Translocation;Organelles;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis Imperfecta;Outcome;Partner in relationship;Pathway interactions;Patients;Phenotype;Physiological;Potassium;Potassium Channel;promoter;Property;protein expression;Proteins;Raman Spectrum Analysis;Rare Diseases;receptor;release of sequestered calcium ion into cytoplasm;Research;Resistance;Resolution;response;Role;second harmonic;Second Messenger Systems;Signal Transduction;Signal Transduction Pathway;skeletal;skeletal disorder;skeletogenesis;Skeleton;Structure;success;targeted treatment;Testing;Tissues;Transforming Growth Factor beta;Treatment Efficacy;Western Blotting;Work

PROJECT_TITLE: Osteogenesis imperfecta caused by TMEM38B mutation: a deep investigation of cellular and extracellular consequences to identify new therapeutic targets

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-1 (01)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_CITY: Newark

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE SARS-CoV-2 remains a threat due to continuously evolving new variants, and fully vaccinated people remain susceptible to infection by the newer variants of the virus. SARS-Cov-2 can infect cells including oral epithelial cells via ACE2-independent alternative receptors, and infection via alternative receptors (e.g. CD147) is resistant to anti-spike RBD, which is the target for several SARS-CoV-2 vaccines to block ACE2 binding. Our studies will address the role of alternative in SARS-CoV-2 infection and virus-mediated immune activation in region-specific oral epithelial cells and tissues. It is critical to understand the role of alternative receptors for SARS-CoV-2 in the oral mucosa, the potential portal of SARS-CoV-2 entry, to develop anti-viral therapeutics and strategies to dampen virus-mediated immune activation and disease outcomes, especially as regards emerging immune escape variants.

PI_NAMEs: CHANG, THERESA L (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: 2019-nCoV;ACE2;Aftercare;Anti-viral Agents;Antibodies;antiviral drug development;Binding;Cells;Centers for Disease Control and Prevention (U.S.);Clinical;coronavirus disease;COVID-19;COVID-19 susceptibility;COVID-19 vaccine;Data;defined contribution;Disease;Disease Outcome;Epithelial Cells;Exhibits;Genes;Gingiva;Goals;Human;Immune;immune activation;Immune response;Immune System Diseases;Individual;Infection;Infection prevention;infection risk;Inflammation;knock-down;Knowledge;Laboratories;Location;Maps;Mediating;Membrane;Monoclonal Antibodies;Mucous Membrane;neutralizing antibody;novel vaccines;Oral;Oral cavity;oral cavity epithelium;oral infection;Oral mucous membrane structure;oral tissue;Organ;Play;Predisposition;Prevention strategy;Proteins;Public Health;public health emergency;receptor;receptor binding;receptor expression;Reporting;Research;Resistance;respiratory;RNA;Role;Saliva;Salivary;Salivary duct structure;Salivary Glands;SARS-CoV-2 B.1.1.529;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Serine Protease;Supporting Cell;Testing;Tissues;Tongue;Tonsil;transmission process;Vaccinee;Variant;Viral;Virus;Virus Replication;World Health Organization

PROJECT_TITLE: ACE2-independent alternative receptors for SARS-CoV-2 at the oral mucosa

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative Asymptomatic infections are a main source of malaria transmission and a crucial challenge to elimination. In the frame of a cluster-randomized trial of spatial repellents in western Kenya, we will screen blood samples collected across three time points by qPCR to determine changes in prevalence of infection. We will compare parasite and gametocyte prevalence and density to vector density and sporozoite rates to determine changes in transmission. The proposed project will determine whether spatial repellents can reduce the asymptomatic reservoir of infection.

PI_NAMEs: KOEPFLI, CRISTIAN  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Acceleration;Beds;Blood Screening;Blood specimen;Clinical;Clinical Treatment;Cluster randomized trial;combat;comparison control;Country;Culicidae;Data;density;Diagnosis;Enzyme-Linked Immunosorbent Assay;field study;Funding;Goals;High Prevalence;Human;improved;Incidence;Individual;Infection;Intervention;Kenya;Knowledge;Life Cycle Stages;Link;Location;Malaria;malaria infection;malaria transmission;Measures;Microscopy;Morbidity - disease rate;mortality;novel;Outcome;Parasites;Parasitology;Persons;Placebos;Plasmodium falciparum;Prevalence;programs;Research;response;sample collection;Sampling;Sexual Transmission;Site;Source;Sporozoites;Surrogate Markers;Surveys;Testing;Time;tool;transmission process;treatment strategy;vector;vector control;Volatilization;Work

PROJECT_TITLE: The Impact of Novel Vector Control Tools on Asymptomatic Plasmodium falciparum Infection Prevalence and Transmission Potential

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed studies will determine the extent to which aging of the colon in mice is associated with deficiency in cGMP signaling. It will test the ability of cGMP-elevating agents to normalize homeostasis, slow transit, barrier dysfunction and inflammation, that characterize intestinal pathology of aged mice. The project will also determine whether intestinal organoids from aged mice are a suitable model to interrogate mechanisms of aging in the gut.

PI_NAMEs: BROWNING, DARREN D. (contact)

PROGRAM_OFFICER_NAME: FLORES, ROBERTO L

PROJECT_TERMS: Affect;Age;aged;Aging;aging mechanism;Agonist;Animals;Automobile Driving;Blood Vessels;Chronic;Colon;Colon Carcinoma;Colorectal Cancer;Constipation;Cyclic GMP;Cyclic GMP-Dependent Protein Kinases;Data;Disease;Drug Targeting;dysbiosis;economic cost;Elderly;Enteral;enterotoxin receptor;Epithelium;Exhibits;FDA approved;Functional disorder;Future;gastrointestinal epithelium;Gastrointestinal tract structure;Genitourinary system;Goals;guanylin;gut inflammation;Health;Healthcare;Homeostasis;Human;Hydrolysis;Incidence;Individual;Inflammaging;Inflammation;inhibitor;intestinal barrier;Intestinal Diseases;intestinal epithelium;Intestines;juvenile animal;Knockout Mice;Laboratories;Lamina Propria;Measures;Mediating;Modeling;Morbidity - disease rate;Motility;Mus;Nerve;nerve supply;Nociception;old mice;older patient;Older Population;Organoids;Outcome;Pathologic;Pathology;Pathway interactions;Peptides;Phenotype;phosphodiesterase V;Population;Prevention strategy;Process;Proliferating;Publishing;Regenerative capacity;Regional Disease;Regulation;response;Rodent;Role;Signal Pathway;Signal Transduction;sildenafil;socioeconomics;solute;stem cells;System;systemic inflammatory response;Testing;Therapeutic Intervention;therapeutic target;Tissues;treatment strategy;uroguanylin;Western Blotting;young adult

PROJECT_TITLE: The cGMP-signaling axis in intestinal aging.

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Ubiquitous microbial surface fibers called type 4 pili are required for some bacteria that cause serious and potentially fatal disease for initial infection and subsequent illness. A molecular machine powered by an enzyme that converts chemical into mechanical energy extends and retracts these fibers, but how that machine works is not well understood. We will gain insight into the function of the enzyme by studying its structure and function.

PI_NAMEs: DONNENBERG, MICHAEL S (contact);SAMSO, MONTSERRAT

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: 3-Dimensional;Adherence;analog;Animals;Antibiotics;Antimicrobial Resistance;appendage;Archaea;ATP Hydrolysis;ATP phosphohydrolase;Bacteria;Bacterial Infections;bacterial resistance;Biological Models;Catalysis;Chemicals;Clostridium difficile;Codon Nucleotides;Complex;Cryoelectron Microscopy;Crystallization;Cytoplasm;Data;Data Collection;Diarrhea;Dinucleoside Phosphates;Disease;Disparate;Distant;DNA;Energy consumption;enteropathogenic Escherichia coli;Enzymatic Biochemistry;enzyme activity;Enzyme Kinetics;Enzymes;Exhibits;Family member;Fiber;Fimbriae Proteins;Gram-Negative Bacteria;Hair;Human;human pathogen;Image;Infant;Infection;insight;Investigation;Kinetics;Knowledge;Locomotion;Measures;mechanical energy;Membrane;microbial;Microbial Biofilms;microorganism;Microscope;Modeling;Molecular;Molecular Conformation;Molecular Machines;monomer;Multienzyme Complexes;Negative Staining;Neisseria meningitidis;novel strategies;Nucleotides;Organism;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Perch;periplasm;Persons;Phase;Phylogeny;Pilum;Preparation;prevent;Process;Proteins;Pseudomonas aeruginosa;Publishing;reconstruction;Recording of previous events;Research Personnel;Resolution;Sampling;screening;Structure;success;Surface;System;Therapeutic;thermophilic bacteria;thermophilic organism;Transmission Electron Microscopy;Trees;two-dimensional;uptake;Vibrio cholerae;Virulence;Virulence Factors;volunteer;Work;X-Ray Crystallography

PROJECT_TITLE: Enzymology and Structure of Divergent Type 4 Pilus Extension ATPases

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Narrative Chronic infections and cancer result in dysfunction of immune cells, termed “exhaustion”. With this proposal, we will use microRNA technology in order to overcome exhaustion. We will develop a novel method to deliver microRNAs to exhausted cells in vivo in order to promote their protective function against chronic infections and cancer.

PI_NAMEs: STELEKATI, ERIETTA  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: anti-PD-1;Antigens;Antitumor Response;Attenuated;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cells;Chronic;chronic infection;Clinical;Data;Epigenetic Process;exhaust;exhaustion;Exposure to;Fluorescence;Genetic Transcription;Goals;Immune;Immune checkpoint inhibitor;Immune response;Immune System Diseases;Immune Targeting;Immunotherapeutic agent;Immunotherapy;improved;in vivo;inhibitory surface receptor;Label;Lymphocyte;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Melanoma;Melanoma Cell;Memory;Messenger RNA;Methods;microRNA delivery;MicroRNAs;Mus;neoplastic cell;novel;overexpression;Pancreatic Ductal Adenocarcinoma;pathogen;Pathway interactions;Phase;prevent;progenitor;programmed cell death protein 1;response;Role;success;synergism;T cell differentiation;T cell response;T-Lymphocyte;Technology;Testing;tumor;Tumor Immunity;tumorigenesis;Untranslated RNA;uptake;Viral;Virus Diseases

PROJECT_TITLE: Delivering miR-29a to enhance anti-viral and anti-tumor responses in vivo

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Substance Misuse;Substance Misuse Prevention

ORG_CITY: DURHAM

ORG_NAME: INNOVATION RESEARCH AND TRAINING, INC.

PHR: Project Narrative Children affected by substance misuse are a vulnerable and underserved population of youth. Supporting their healthy growth and development is of utmost importance. The proposed evaluation of a web-based training for mentoring program staff members and mentors working with substance misuse-affected youth (SMAY) fills an important gap in service needs for the field of mentoring. Mentor training has been shown to support the development of close, long-lasting mentoring relationships; however, few training resources specific to issues relevant to mentoring substance-misuse affected youth exist. The main purpose of this project is to evaluate Substance of Change: Building Assets in Mentees Affected by Substance Misuse (SOC), an interactive, multimedia, web–based, asynchronous training for mentors and staff working with SMAY to determine its effects on mentor and staff outcomes.

PI_NAMEs: KUPERSMIDT, JANIS B (contact);STUMP, KATHRYN N

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: 17 year old;Address;Adopted;Adoption;Affect;Age;Aggressive behavior;alcohol misuse;Area;Attitude;Award;Behavior;Characteristics;Child;Clinical Psychology;Communities;conduct problem;Coping Skills;Country;Course Content;course development;design;deter alcohol use;Development;drug misuse;E-learning;Educational process of instructing;Effectiveness;effectiveness evaluation;Empathy;Evaluation;Evaluation Studies;evidence base;Family member;Feedback;Foundations;Friends;Funding;Future;Goals;Grant;Group Meetings;Growth and Development function;Health Knowledge Attitudes Practice;high risk sexual behavior;improved;Individual;Intention;Intervention;Interview;Knowledge;knowledge base;Lead;Leadership;Learning;Life Cycle Stages;member;Mentors;Methods;Multimedia;Online Systems;Opioid;opioid epidemic;opioid misuse;opioid use;Outcome;Pain management;Parents;Persons;Pharmaceutical Preparations;positive youth development;premature;Preparation;prevent;Prevention program;Problem Solving;Process;Program Development;programs;Randomized, Controlled Trials;Readiness;Recovery;reduced substance use;Research;Research Proposals;Resources;Risk;Self Efficacy;service delivery;Services;skills;skills training;Staff Development;Standardization;Stress and Coping;substance misuse;substance misuse prevention;substance use;Substance Use Disorder;System;tool;Training;Training Programs;Truancy;Underserved Population;volunteer;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Substance of Change: Evaluation of Web-Based Training for Mentors and Staff Serving Youth Impacted by Substance Misuse

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative Airway stenosis resulting from various reasons including but not limited to endotracheal intubation, tracheostomy, autoimmune diseases and infection is challenging to treat because prolonged intubation often leads to high risk of respiratory and vocal dysfunction. This project aims to quantify improvements in wound healing and tissue biomechanics for airway stenosis using a novel dose-controllable, injectable therapeutic delivery loaded with corticosteroid and antimicrobial. The long-term goal of this research is to develop a platform to optimize wound healing of the airway through novel drug delivery approaches.

PI_NAMEs: DION, GREGORY ROBERT;PARK, YOONJEE  (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: Absorbable Implants;Adjuvant;Adjuvant Therapy;Admission activity;Adrenal Cortex Hormones;Adult;Aftercare;airway inflammation;Antibiotics;antimicrobial;Autoimmune Diseases;Bacteria;Bacterial Antibiotic Resistance;Biomechanics;Blood Vessels;Breathing;capsule;Cervical;Cicatrix;Clinical;clinically relevant;Complex;Data;Deglutition;Development;Dexamethasone;Diameter;Disease;Dose;Drug Delivery Systems;Drug Implants;Drug Kinetics;drug release kinetics;Drug usage;Effectiveness;endotracheal;Excision;Fibrosis;Foundations;Functional disorder;Geometry;Glucocorticoids;Goals;healing;high risk;Histologic;Immune response;immunoreaction;Implant;implant design;Implantable Infusion Pumps;implantation;improved;In Vitro;in vivo;Infection;Inflammatory;Injectable;Injections;Injury;innovation;Intensive Care Units;Intratracheal Intubation;Intubation;Investigation;irradiation;Laryngeal Injury;Lasers;Lesion;Levaquin;Light;Measures;microbiome;microbiome sequencing;microbiota;minimally invasive;Modeling;Mucositis;Mucous Membrane;novel;novel therapeutics;Operative Surgical Procedures;optical fiber;Oryctolagus cuniculus;Outcome;Pathogenesis;Patients;Pharmaceutical Preparations;Postoperative Period;Pre-Clinical Model;Procedures;Property;Public Health;Repeat Surgery;Reporting;Research;respiratory;Respiratory Failure;respiratory microbiome;response;Risk;Role;Stenosis;Subglottis structure;Submucosa;System;Technology;Testing;Therapeutic;Time;Tissues;Trachea;Tracheal Stenosis;Tracheostomy procedure;Treatment Efficacy;treatment optimization;treatment strategy;Tube;Ulcer;Upper respiratory tract;Voice;whole genome;Work;wound healing

PROJECT_TITLE: INJECTABLE, TUNABLE CO-DELIVERY THERAPEUTIC IMPLANT TO REDUCE AIRWAY STENOSIS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (83)]


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Traumatic Brain Injury (TBI) and subsequent glutamate excitoxicity can trigger a sequence of pathological changes that lead to post-traumatic epilepsy (PTE) with a delay that can be weeks to months after the initial injury, and this long latency presumably provides an opportunity to develop treatments that prevent PTE, but no such treatment exists. As clavulanic acid is already FDA approved for human use, positive data from our proposed studies may be rapidly translated to further development of this post-TBI treatment strategy, and to human trials. Beyond post-traumatic epilepsy, enhancement of glutamate transport may also prove useful following various other forms of brain injury, such as stroke or infection.

PI_NAMEs: ROTENBERG, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: 8-hydroxy-2'-deoxyguanosine;acquired epilepsy;Acute;addiction;Address;Animal Model;Anti-Bacterial Agents;Antibiotics;Antiepileptogenic;Astrocytes;astrogliosis;Basic Science;beta-Lactamase;beta-Lactams;Brain;Brain Injuries;Budgets;Ceftriaxone;Cells;Cessation of life;Chronic;Clavulanic Acids;Clinical;Clinical Trials;cohort;Data;Depressed mood;design;Development;Dose;Down-Regulation;Electroencephalography;Epilepsy;Epileptogenesis;excitotoxicity;experimental study;Exposure to;extracellular;Extracellular Space;FDA approved;Frequencies;Functional disorder;Genes;Glial Fibrillary Acidic Protein;Glutamate Transporter;Glutamates;Human;Immunohistochemistry;Incidence;Infection;inhibitor;Injectable;Injections;injured;Injury;Interneurons;Intervention;Lactams;Liquid substance;Measures;Mediating;Medical;Mental Depression;Metabolic;Methods;Modeling;Molecular;neuron loss;Neuronal Injury;Neurons;neuroprotection;novel;Oral;Oxidative Stress;painful neuropathy;Parvalbumins;Pathologic;Pentylenetetrazole;Percussion;Pharmaceutical Preparations;Physiologic pulse;Post-Traumatic Epilepsy;pre-clinical;prevent;Property;protein expression;Proteins;Publishing;Rattus;Regulation;response;Role;Seizures;Severities;Somatostatin;Stains;stressor;Stroke;Sulbactam;Symptoms;Synapses;TBI treatment;Testing;Therapeutic Effect;Toxic effect;Transcranial magnetic stimulation;Translating;Trauma;Traumatic Brain Injury;treatment strategy;Up-Regulation;Western Blotting;wireless;Withholding Treatment;Work;young adult

PROJECT_TITLE: Mitigating Post-Traumatic Epileptogenesis by Enhancing Synaptic Glutamate Transport via Long-Term Non-Bactericidal Beta-Lactam Administration

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative: The anterior lobe of the cerebellum is an important locus in several neurological conditions. The classical mouse mutation meander tail reveals a compartmentation boundary between anterior and posterior lobes of the cerebellum but has resisted efforts at molecular identification for nearly 50 years. This application proposes to close this gap in knowledge using recent developments in genomic technologies to identify two meander tail mutations and their molecular consequences during brain development.

PI_NAMEs: HAMILTON, BRUCE A (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Address;Affect;Alleles;Anatomy;Animal Model;Anterior;Biology;Brain;causal variant;Cell Nucleus;Cells;Cerebellar Ataxia;Cerebellum;Characteristics;Chimera organism;Chromatin;Chromosome Mapping;Code;Complement;congenic;Data;Defect;Degenerative Disorder;Development;developmental disease;Disease;DNA sequencing;epigenomics;Etiology;Exons;Family;Future;Gene Expression Profile;Genes;Genetic;Genetic Transcription;genome sequencing;genome-wide;genomic tools;Genomics;Germ Lines;granule cell;Human;In Situ Hybridization;insertion/deletion mutation;Knock-out;Knowledge;Left;Literature;Lobe;Location;malformation;Maps;Methods;Modeling;Molecular;mouse genetics;multiple omics;Mus;Mutagenesis;mutant;Mutation;Names;Nature;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurologic;novel;Outcome;Parents;Pattern;Phenotype;pleiotropism;positional cloning;Predisposition;Proteins;Recurrence;Reporting;Resistance;response;Sensorimotor functions;single nucleus RNA-sequencing;Site;Spatial Distribution;spine bone structure;stem cells;Structural Genes;Tail;Technology;Testing;Time;Transplantation;Untranslated RNA;Variant;Work

PROJECT_TITLE: Meander tail and development of the anterior lobe.

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Orphan Drug;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Dilated cardiomyopathy (DCM) is a prevalent cause of heart failure and death, yet there are only a few approaches to its treatment and none based on reversing underlying disease mechanisms. This proposal evaluates the therapeutic potential of a novel signaling pathway discovered from genetic screening using human in vitro and mouse in vivo models of DCM. The proposed studies provide confirmation needed for clinical translation.

PI_NAMEs: MERCOLA, MARK  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Address;Affect;Age Months;Antioxidants;BACH1 gene;Biological Assay;Cardiac Myocytes;Cause of Death;Cessation of life;ChIP-seq;Clinical;clinical translation;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Development;Dilated Cardiomyopathy;Disease;disease model;Disease Progression;DNA Sequence Alteration;efficacy testing;Endoplasmic Reticulum;Engineering;Evaluation;experimental study;familial dilated cardiomyopathy;Functional disorder;functional genomics;Genes;Genetic Screening;Health;Heart failure;Human;human induced pluripotent stem cells;improved;In Vitro;in vivo;in vivo Model;Individual;induced pluripotent stem cell;Inherited;insight;Intervention;Kinetics;Knock-in;Knockout Mice;Knowledge;life span;Malignant Neoplasms;Measures;Mediating;Metabolic;Metabolic dysfunction;Microfilaments;Modeling;Molecular Genetics;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;Muscle function;muscular structure;mutant;Mutation;mutation correction;Myocardial Ischemia;Myocardium;Nervous System Disorder;new therapeutic target;novel;novel strategies;novel therapeutics;Outcome;Pathogenicity;Pathway interactions;Patients;Physiological;Physiology;PRKAG2 gene;Process;protective effect;Reporting;Research;response;restoration;Role;Sarcoplasmic Reticulum;screening;Severities;Signal Pathway;Signal Transduction;Small Interfering RNA;Stress;sudden cardiac death;Testing;Therapeutic;Therapeutic Effect;therapeutic target;transcriptome sequencing;Transgenic Mice;Transgenic Model;Transgenic Organisms;Translating;treatment response;Validation;validation studies;Variant;Whole Organism

PROJECT_TITLE: Evaluation of the AMPK-BACH1-NRF2 Axis as a Therapeutic Target for Inherited DCM

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ORG_DEPT: CHEMISTRY

PHR: Project Narrative. This program provides new insight into a recently discovered primary metabolic pathway in bacteria, sphingolipid biosynthesis, which appears to bridge fatty acid biosynthesis in pathogenic bacterial species. Structural data developed from this program will provide critically needed information to understand the mode and mechanisms of protein • protein interactivity that enable the progression of this pathway in pathogenic bacteria. While bacterial fatty acid biosynthesis is a validated antibiotic drug target, this discovery and data obtained from this program will serve as a critical next step towards understanding the fundamentals of associated lipid metabolism within bacterial pathogenesis.

PI_NAMEs: BURKART, MICHAEL D. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acyl Carrier Protein;Acylation;Address;Anabolism;Antibiotics;Bacteria;Binding;Biotin;Carrier Proteins;Cell division;Charge;Chemicals;comparative;Complex;crosslink;Crosslinker;Data;drug discovery;Drug Targeting;Environment;enzyme activity;Enzyme Kinetics;Enzymes;Equilibrium;Escherichia coli;fatty acid biosynthesis;Fatty Acids;Fatty-acid synthase;Future;Goals;Growth;Human;Human Microbiome;insight;Kinetics;Laboratories;Link;lipid metabolism;Lipids;Lipopolysaccharides;Listeria monocytogenes;member;Metabolic;Metabolic Pathway;Metabolism;Methods;microbial;Mutagenesis;Neisseria gonorrhoeae;Operon;pathogen;Pathogenesis;pathogenic bacteria;pathogenic Escherichia coli;Pathogenicity;Pathway interactions;Play;progenitor;programs;protein crosslink;protein protein interaction;Proteins;Pseudomonas aeruginosa;Regulation;Role;Salmonella typhimurium;serine palmitoyltransferase;Site;Sphingolipids;Staphylococcus aureus;structural biology;Structure;symposium;System;therapeutic target;Thioctic Acid;Time;Titrations;tool;Virus;X-Ray Crystallography

PROJECT_TITLE: Cryptic bacterial carrier proteins bridging fatty acid synthase

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: EAST LANSING

ORG_DEPT: NEUROSCIENCES

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: Project Narrative Synapse loss caused by the accumulation of pathological tau is likely responsible for cognitive decline in Alzheimer’s disease. Within the central nervous system, the complement system (and specifically complement component C1q) coordinates the phagocytic removal of synapses by microglia, however the exact mechanisms by which the complement system can differentiate between healthy synapses and those needing pruning is currently unknown. The goal of this application is to determine the molecular mechanisms that coordinate the synaptic deposition of complement C1q in a model of tauopathy.

PI_NAMEs: BENSKEY, MATTHEW JOHN (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Address;Affect;Age;Age Months;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Animal Model;Autopsy;Binding;Biochemical;Brain;Cells;Central Nervous System;Cessation of life;Co-Immunoprecipitations;cognitive function;Complement;Complement 1q;Complement Activation;complement system;Complex;Data;Dementia;Deposition;Disease;Excision;genetic regulatory protein;Goals;Hippocampus;Histologic;Human;human tissue;Immunoprecipitation;Impaired cognition;improved;Individual;Innate Immune System;Knowledge;Label;Lipids;Mass Spectrum Analysis;Mediating;Membrane;Microglia;Modeling;Molecular;mouse model;Mus;mutant;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurons;pathogen;Pathologic;Phagocytes;Play;preservation;prevent;Process;Proteins;Quality of life;recruit;response;Role;Synapses;Synaptic Membranes;synaptic pruning;Synaptosomes;tau mutation;tau Proteins;Tauopathies;Therapeutic Intervention;Time;Tissues;Transgenic Organisms;Wild Type Mouse

PROJECT_TITLE: Investigating Mechanisms of Complement Mediated Synaptic Removal

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics;Health Effects of Indoor Air Pollution;Lung

PHR: Exposure to burn pits are a public health threat to those in the Armed Forces who are serving or have served in the Middle East and Africa. Our studies investigate the acute and chronic effects of exposure on lung health in studies of a mouse model that closely mimics the human exposure to burn pit toxicants, particularly the immune responses and the changes in the lung microenvironment that impact on the response. Our goal is to understand the critical pathways of the immune response that regulate the changes that occur during multiple compared to single acute exposure, with the expectation that mechanisms of lung resiliency and a therapeutically targetable pathway will emerge and will prove useful in modulating lung disease due to burn pit toxicants and to other environmental exposures.

PI_NAMEs: DOERSCHUK, CLAIRE M (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Accounting;Acute;Africa;Air;Air Pollutants;alveolar epithelium;Antioxidants;Area;B-Lymphocytes;Biological Response Modifiers;bronchial epithelium;Bronchiolitis;Bronchitis;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Burn injury;burn pit;Caring;CCL2 gene;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chemokine;Chronic;Collaborations;combustion product;Complex;Critical Pathways;CSF3 gene;cytokine;Data Analyses;design;Development;ds-DNA;Dust;Environmental Exposure;Epithelial Cells;Epithelium;Equipment;exhaust;expectation;experience;exposed human population;Exposure to;extracellular;Flow Cytometry;Gases;Goals;Heterogeneity;high risk;Hour;Immune;immune cell infiltrate;Immune response;Immunologic Markers;Individual;Industry;Inflammation;Inflammatory;Inflammatory Response;Interleukin-10;Interleukin-12;Intervention;Location;Lung;Lung Diseases;lung health;Lung immune response;lung injury;lung repair;Macrophage;Measures;Mediator;member;Messenger RNA;Middle East;Military Personnel;mouse model;multiplex assay;Mus;Natural Killer Cells;Nature;neutrophil;Neutrophil Infiltration;new technology;novel;Pathway interactions;Plastics;Proteins;Proteome;Public Health;Pulmonary Inflammation;recruit;resilience;response;Saline;Services;Signal Pathway;single-cell RNA sequencing;Site;Structure of parenchyma of lung;System;Temperature;Testing;Therapeutically Targetable;Toxic Environmental Substances;toxicant;transcriptome;wasting

PROJECT_TITLE: The pulmonary immune response induced by single and multiple exposures to combustion products of burn pit constituents

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Digestive Diseases;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research;Pediatric;Telehealth

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Disorders of gut-brain interaction (DGBI, former known as functional abdominal pain disorders) like irritable bowel syndrome are highly prevalent worldwide in children and adults and are associated with significant morbidity like increased psychological distress (e.g., anxiety and depression) and impaired health-related quality of life. Based on clinical trials demonstrating consistent efficacy of psychological therapies especially when delivered remotely, we developed a patient-centered guided imagery therapy mobile application (GIT App) to treat children with DGBI; however, insight about how to implement such a therapeutic mobile app within pediatric clinics is unclear. Utilizing implementation science methodologies, this proposal aims to identify local clinic personnel’s perspectives about their perceived barriers and inherent facilitators that may impact the implementation of our GIT App intervention in pediatric clinics to ultimately increase access to an optimal psychological therapy and improve health outcomes for pediatric patients with DGBI.

PI_NAMEs: HOLLIER, JOHN M (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Abdominal Pain;Acceleration;Address;Adopted;Adoption;Adult;Affect;Anxiety;Assessment tool;Biochemical;biopsychosocial;care delivery;Caring;Cellular Phone;Child;child depression;Childhood;childhood anxiety;chronic abdominal pain;chronic pain;Clinic;Clinical;Clinical Trials;Cognitive Therapy;Communities;Compact discs;Consolidated Framework for Implementation Research;cost;Data;Development;Disease;disorders of gut-brain interaction;Economic Burden;economic impact;Effectiveness;effectiveness/implementation trial;efficacious treatment;Electronics;Etiology;Evidence based intervention;Evidence based treatment;Funding;Future;future implementation;Goals;Guided imagery;Guidelines;Health;Health Care Costs;health care delivery;health related quality of life;Hospitalization;Human Resources;Hypnotherapy;Impaired health;implementation barriers;implementation determinants;implementation efforts;implementation facilitators;implementation intervention;implementation process;implementation science;implementation strategy;improved;Individual;insight;Insurance Coverage;Intervention;Intervention Studies;Interview;Irritable Bowel Syndrome;Life;Literature;Manuscripts;Medical;Mental Depression;Mental Health;Methodology;Methods;mobile application;Modeling;Modernization;Morbidity - disease rate;National Institute of Diabetes and Digestive and Kidney Diseases;Nurses;Online Systems;organizational readiness;Pain;Pain Disorder;patient oriented;Patients;pediatric health outcomes;pediatric patients;Pediatrics;peer;Persons;preempt;Primary Care;Provider;psychologic;psychological distress;Psychological Impact;Qualifying;Qualitative Methods;Readiness;Recommendation;remote delivery;Research;Research Methodology;Research Personnel;Sea;Strategic Planning;Structural defect;Surveys;system-level barriers;systemic barrier;Tablets;theories;Therapeutic;Translational Research;treatment guidelines;Variant;Visit;web site

PROJECT_TITLE: Identifying Clinic Barriers and Facilitators Affecting the Implementation of a Mobile App-Based Treatment for Disorders of Gut-Brain Interaction in Children.

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

ORG_STATE: WA

PHR: Narrative The placenta is an essential organ for healthy maternal-fetal outcomes. However, molecular mechanisms of placental dysfunction in obstetric disorders are not well understood. We will conduct statistical analysis on data from observations of placental tissue (metabolites, proteins, transcript RNA, and histopathology), together with clinical data from patients' charts. This study of the underlying mechanisms of placental health and disease aims to find and help prioritize new areas of research for improving obstetric outcomes.

PI_NAMEs: HADLOCK, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TITLE: Enhancing insight into placental dysfunction in common obstetric disorders using placental multiomics

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Patient Safety;Rare Diseases

ORG_CITY: GARRISON

ORG_NAME: HASTINGS CENTER, INC.

PHR: PROJECT NARRATIVE The translational gene therapy ecosystem faces several interrelated challenges: 1) obtaining sufficient evidence of safety/efficacy from clinical trials to justify regulatory approval of new gene therapies to treat inherited diseases, various cancers, and other complex diseases; 2) establishing cost and payer coverage policies so patients have access to affordable treatments; and 3) generating sufficient safety and effectiveness evidence of approved gene therapies when used in the clinical setting. The project will develop recommendations and issue/policy briefs to help stakeholders in the translational gene therapy ecosystem in their deliberations and decision-making about addressing gene therapy challenges and associated ethical and policy issues and to identify ethical and policy issues within the translational gene therapy ecosystem that warrant additional normative and empirical investigation by various stakeholders.

PI_NAMEs: GUSMANO, MICHAEL KELLEY;MASCHKE, KAREN JOANN (contact);MCCORMICK, JENNIFER BLAIR

PROGRAM_OFFICER_NAME: STERLING, RENE

PROJECT_TERMS: Address;Adopted;Adrenoleukodystrophy;Adult;Advisory Committees;Alleles;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;B-Cell Acute Lymphoblastic Leukemia;B-Cell Lymphomas;beta Thalassemia;Bioethics;Blood;CAR T cell therapy;Cerebrum;Child;chimeric antigen receptor T cells;Clinic;Clinical;Clinical Trials;Communicable Diseases;Complex;Congresses;cost;Decision Making;design;Development;Disease;Ecosystem;Effectiveness;effectiveness clinical trial;efficacy clinical trial;ethical, legal, and social implication;Ethics;Face;FDA approved;Follicular Lymphoma;Food and Drug Administration Drug Approval;Future;gene therapy;gene-targeted therapy;Genes;Genetic;Genomics;Health;Health Policy;Healthcare Systems;Hematological Disease;Hematology;Hematopoietic Neoplasms;Hemophilia A;Hemophilia B;Hereditary Disease;Industry;Inherited;innovation;Interview;Investigation;Link;Malignant Neoplasms;Mantle Cell Lymphoma;Medicaid;Medical Technology;member;Metabolic Diseases;Multiple Myeloma;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurology;novel therapeutics;Oncology;Organ;Outcome;Parkinson Disease;Patient advocacy;patient safety;Patients;Pennsylvania;Physicians;Policies;Policy Analysis;Policy Maker;Politics;post-market;Process;Public Policy;public trust;Rare Diseases;Recommendation;Research;Research Methodology;Research Personnel;Retinal Dystrophy;RPE65 protein;Safety;safety testing;Science;Sickle Cell Anemia;Solid;Spinal Muscular Atrophy;Surveys;Therapeutic;Therapeutic Studies;therapy development;Translational Research;United States Centers for Medicare and Medicaid Services;United States Food and Drug Administration;Universities

PROJECT_TITLE: From Research to Clinic: Addressing Ethical and Policy Challenges Facing the Gene Therapy Ecosystem

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Project Narrative Pediatric nonadherence to medication is a significant public health problem, and rigorous research repeatedly documents that nonadherence increases risk for hospitalization, healthcare cost, disease progression, and death. Our preliminary data documents that 93% of parents experience barrier(s) to medication administration. The goal of this study is to test the effectiveness of MedSupport, a novel multi-level intervention designed so address root barriers to pediatric medication adherence.

PI_NAMEs: BOUCHARD, ELIZABETH  (contact);KELLY, KARA M

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Acute Lymphocytic Leukemia;Address;Adherence;Adolescent;Age;Awareness;behavior measurement;Biological Markers;biomarker validation;burnout;Cancer Relapse;cancer risk;Caregivers;caregiving;Cause of Death;Cessation of life;chemotherapy;Child;Childhood;Childhood Acute Lymphocytic Leukemia;Clinical;clinical practice;clinical research site;Clinical Trials;clinically significant;Communication Barriers;Companions;Confusion;cost;Dana-Farber Cancer Institute;Data;design;Disease;Disease Progression;Education;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;Electronics;Elements;Enrollment;experience;Family;Family Characteristics;Frustration;Future;future implementation;Geographic Locations;Goals;Health Care Costs;Health Personnel;Healthcare;Home;Hospitalization;Household;implementation outcomes;implementation strategy;implementation/effectiveness;improved;Infrastructure;Ingestion;innovation;Instruction;Intervention;Malignant Childhood Neoplasm;Measurement;Measures;Mediator;Medical Care Team;medication administration;medication compliance;Medicine;Methodology;Monitor;multi-site trial;multidisciplinary;novel;Only Child;Parents;Participant;Patient Recruitments;Patients;Pattern;pediatric patients;Pharmaceutical Preparations;pharmacologic;Physicians;programs;Public Health;Randomized;recruit;Regimen;Reporting;Reproducibility;Research;Research Design;Resistance;Resources;Risk;routine care;Schedule;screening;side effect;Site;Socioeconomic Status;Standardization;Structure;Testing;theories;Therapeutic Trials;therapy adherence;therapy design;Translating;translational impact;Translations;treatment as usual;Trust;uptake;virtual education;Work

PROJECT_TITLE: MedSupport: A Novel Multilevel Intervention to Identify and Address Barriers to Pediatric Medication

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Aging;Clinical Research;Genetics;HIV/AIDS;Infectious Diseases;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE While effective at suppressing HIV replication, current antiretroviral therapy (ART) does not eliminate the persistent HIV reservoir nor prevent HIV gene expression from “active” reservoir cells, which can result in low- level chronic inflammation. This may be particularly problematic in aged people with HIV, who exhibit additional low-level inflammation due to the aging process itself. Here, using blood and tissue specimens from aged ART- treated men and women with HIV, we propose to characterize the phenotypic and transcriptional features of “active” reservoir cells, to study the mechanisms by which ongoing HIV gene expression can promote viral persistence and chronic inflammation, and to identify and test novel drugs that prevent ongoing HIV gene expression.

PI_NAMEs: OTT, MELANIE MARIA;ROAN, NADIA R (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: Affect;Age;Age Years;aged;Aging;aging population;aging process;Antigens;antiretroviral therapy;assay development;Base Sequence;biological sex;Biopsy;Blood;Blood specimen;candidate validation;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Line;Cell model;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Chronic;Clonal Expansion;Cohort Studies;comorbidity;Contracts;Cytomegalovirus;Data;DNA;Drops;Elderly;Epidemic;Estradiol;Estrogens;Estrone;Exhibits;Female;Gene Expression;gene product;Genetic Transcription;Germ Cells;Goals;Gonadal Steroid Hormones;HIV;human old age (65+);Immune;In Vitro;Individual;Infection;Inflammaging;Inflammation;Infrastructure;inhibitor;innovation;Lead;lead optimization;male;Measures;men;Menopause;Modeling;Molecular Target;mortality;multiple omics;novel;novel strategies;novel therapeutics;Participant;Pathway interactions;Patients;Perimenopause;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenotype;Postmenopause;prevent;Process;Production;programs;Proteins;Recording of previous events;resistance mutation;RNA;screening;sex;Sex Differences;Shoulder;single cell sequencing;single-cell RNA sequencing;Site;Specimen;synergism;tat Protein;Technology;Testing;therapy adherence;Tissue Model;Tissues;Transcriptional Regulation;transcriptome;United States National Institutes of Health;Viral;Viral Genes;viral resistance;Viremia;Virion;Visit;Woman

PROJECT_TITLE: Targeting the transcriptionally-active reservoir to reduce chronic inflammation in aged people with HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JBS-A (J1)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Assistive Technology;Bioengineering;Biomedical Imaging;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE: Bacterial infections are a major threat to global human health. Those that establish biofilms on and around implants such as catheters and joint replacements are particularly problematic. In this proposal, we develop and test new agents that bind to bacteria, even in biofilms, to allow sensitive and specific detection, enabling earlier treatment of infections and thus better patient outcomes.

PI_NAMEs: THOREK, DANIEL LYNDON JAFFE (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Affinity;Anatomy;Animals;Antibiotics;Bacteremia;Bacteria;Bacterial Infections;bacterial resistance;Binding;Binding Proteins;Biodistribution;Biological Assay;bone;cancer therapy;cardiac device;Cardiac pacemaker;Catheters;Cell surface;Cell Wall;Chelating Agents;chelation;Clinical;clinical translation;clinically relevant;Communicable Diseases;Complex;dalbavancin;Data;Dedications;Deferoxamine;Detection;Development;Devices;Diagnosis;Diagnostic Imaging;Discipline of Nuclear Medicine;Drug Kinetics;Early Diagnosis;Early treatment;Economics;Edema;Enterococcus;Environment;Evaluation;FDA approved;Fever;fluorodeoxyglucose;Genus staphylococcus;global health;Goals;Gram-Positive Bacteria;Gram-Positive Bacterial Infections;Growth;Health;Healthcare;Homologous Gene;Hospitalization;Human;human tissue;hydroxamate;Image;imaging agent;Imaging Device;imaging modality;Implant;implant associated infection;improved;In Vitro;in vitro testing;in vivo;in vivo evaluation;in vivo Model;Indwelling Catheter;Infection;Inflammation;Information Management;Intervention;Iron;Isotopes;Joints;Label;Lead;Ligands;Lipids;Lipoprotein Receptor;Mediating;Medical;medical implant;Metals;Microbe;Microbial Biofilms;Monitor;mouse model;Multi-Drug Resistance;multidisciplinary;Mycoses;nanomolar;New Agents;novel;Operative Surgical Procedures;oritavancin;Orthopedics;Pain;pathogen;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Peptidoglycan;Pharmaceutical Preparations;Positioning Attribute;Positron;Positron-Emission Tomography;Proteins;Radioisotopes;radiotracer;receptor;Replacement Arthroplasty;residence;Rodent Model;Role;siderophore receptors;Siderophores;Site;Specificity;Staphylococcal Infections;Staphylococcus aureus;success;Surface;Symptoms;System;targeted imaging;Technology;Testing;Tissues;Tracer;Transition Elements;Transmembrane Transport;uptake;Vancomycin;Vancomycin Resistance;virtual;Virulence

PROJECT_TITLE: Antibiotic-based PET Imaging of Implant Associated Gram-positive Bacterial Infections

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative While the cellular causes of autism spectrum disorder and related neurodevelopmental disorders are unknown, several rare genetic variants correlate with its pathogenesis, including those resulting in either increased or decreased expression or function of proteins coded for by UBE3A. In this proposal we follow up on our discovery that in neurons, Ube3a associates with Golgi satellites (GSats), small mobile organelles that share many properties with the Golgi apparatus. Our goals are to determine how the association of UBE3A proteins with GSats alters the ability of GSats to regulate synaptic properties that are dysregulated in neurodevelopmental disorders.

PI_NAMEs: GREEN, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Acute;Affect;Angelman Syndrome;Architecture;autism spectrum disorder;Behavior;Biological Assay;Cell membrane;Cell surface;Clinical;Code;Data;Dendrites;Dendritic Spines;Development;Disease;Early Endosome;Endocytosis;Endocytosis Pathway;Enzymes;excitatory neuron;experimental study;extracellular;follow-up;Functional disorder;Genetic;genetic variant;Glycoproteins;glycosylation;Goals;Golgi Apparatus;Hippocampus;Image;Impairment;inhibitory neuron;insight;knock-down;Link;link protein;Location;Long-Term Depression;Long-Term Potentiation;Measurement;Mediating;Membrane;Membrane Proteins;Messenger RNA;Modification;Morphology;mouse model;Mus;Neuraminidase;Neurites;Neurodevelopmental Disorder;neuronal cell body;Neurons;novel;Organelles;overexpression;patch clamp;Pathogenesis;Pathway interactions;Polysaccharides;Positioning Attribute;postsynaptic;Preparation;Process;Proliferating;Property;protein function;Protein Secretion;Proteins;Protocols documentation;rare variant;Regulation;repetitive behavior;response;risk variant;Role;Sensory;Series;Sialic Acids;sialylation;Sialyltransferases;Site;Slice;social communication;Surface;Synapses;synaptic function;Synaptic plasticity;Techniques;Testing;Translating;Translations;UBE3A gene;ubiquitin ligase;Variant;Vertebral column

PROJECT_TITLE: The Roles of the Neurodevelopmental Disease-linked Ube3a Protein in Golgi Satellite Function

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Aging;Osteoporosis

ORG_CITY: INDIANAPOLIS

ORG_NAME: MARIAN UNIVERSITY

PHR: Project Narrative Osteoporosis is a disease that affects more than 10 million Americans and places them at heightened risk of fracture, disability, destitution and death. However, there are limited treatments available for this condition and future study is required to identify new therapeutic targets. In this proposal, we examine the pathway utilized by Neuromedin-U in restricting bone formation to inform and enable better strategies for future translational research.

PI_NAMEs: LOWERY, JONATHAN WAYNE (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Address;Affect;Age;American;Award;bone;bone mass;bone turnover;Cessation of life;Chronic;conditional knockout;cost;Coupled;Data;disability;Disease;Female;Foundations;fracture risk;FRAP1 gene;Funding Mechanisms;Future;Goals;Histologic;Histology;Hospitalization;Hypothalamic structure;Impairment;In Vitro;in vivo;Individual;inhibitor;interest;Investigation;knock-down;Knockout Mice;male;Malignant Breast Neoplasm;Mediating;Medical Care Costs;Molecular;Mus;Myocardial Infarction;Names;Neuromedin U;neuromedin U receptor;neutralizing antibody;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;osteoblast differentiation;Osteoblasts;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;Pathway interactions;pharmacologic;primary endpoint;Proteins;receptor;Regulation;Reporting;Research;Resources;Role;Serum Markers;Signal Pathway;Signal Transduction;Signaling Molecule;Skeleton;small molecule;small molecule inhibitor;Stroke;Testing;therapeutic target;Time;translational potential;Translational Research;Uncertainty;United States National Institutes of Health;Work

PROJECT_TITLE: NMUR2 in bone formation

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Intellectual and Developmental Disabilities (IDD);Neurosciences;Nutrition;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative This project is relevant to public health because it proposes a new strategy to treat prenatal and postnatal neurodevelopmental deficits in pyruvate dehydrogenase deficiency, one of the most common mitochondrial disorders in humans. Promising results from this project might transform patient care because available treatments are only prescribed after birth, which is too late to treat brain developmental abnormalities that occur in utero. This project is therefore relevant to the NIH’s mission because it aims to reduce illness and disability.

PI_NAMEs: MARIN-VALENCIA, ISAAC  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: 3 year old;4 year old;Age;Anabolism;Animal Model;Animals;Atrophic;Biochemical;Bioenergetics;Birth;blood-brain barrier crossing;Brain;brain control;Brain Pathology;Bypass;Carbon;carboxylate;Cell Proliferation;cell type;Cells;Characteristics;Child;Citric Acid Cycle;Clinical;Consumption;Control Groups;Corpus Callosum;Cortical Dysplasia;Critical Pathways;Data;Defect;Development;Developmental Process;Diet;disability;Dose;enzyme deficiency;epimerase;Fatal Outcome;Fatty Acids;FDA approved;Foundations;glucose metabolism;Goals;Growth;high risk;Human;Impairment;improved;in utero;in vivo;ineffective therapies;infancy;Injections;innovation;Intervention;ketogenic diet;Ketone Bodies;Knowledge;Label;Life;Life Expectancy;life span;malformation;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;migration;Mission;Mitochondrial Diseases;mouse model;Mus;Muscle hypotonia;Muscle Weakness;Mutase;myelination;Neonatal;neonate;Nervous System;Neurodevelopmental Deficit;Neurologic;Neurologic Deficit;Neurological disability;Neurological outcome;new therapeutic target;novel therapeutic intervention;novel therapeutics;Onset of illness;Outcome;Patient Care;Patients;Pharmaceutical Preparations;Phenotype;postnatal;postnatal period;Predictive Factor;Pregnancy;prenatal;Prenatal Diagnosis;prevent;Process;Propionates;Public Health;pyruvate dehydrogenase;Quality of life;Reaction;Reporting;Research;Role;Seizures;severe intellectual disability;Structural defect;succinyl-coenzyme A;Symptoms;Testing;Therapeutic;Time;Translating;United States National Institutes of Health

PROJECT_TITLE: A New Therapy for Neurodevelopmental Mitochondrial Disorders


NIH_SPENDING_CATS: Aging;Genetics;Neurosciences

PHR: NARRATIVE The ever-growing size of the aging population urges the identification of cell types and genetic programs that can be tapped into to treat age-related conditions. Here, we will leverage the power of the pioneering organism C. elegans to follow up on our exciting discovery that an anion channel expressed in glia controls aging. The functions of this channel and the cell types and genes involved will be deciphered using a multipronged approach. This work will expand our understanding of aging and may identify novel targets for the treatment of age-related diseases.

PI_NAMEs: BIANCHI, LAURA  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Affect;Age;age related;age-related disease;Aging;aging population;aging process;Animals;Anions;Area;Behavior;Bicarbonates;biological adaptation to stress;Biological Assay;Caenorhabditis elegans;Candidate Disease Gene;Cardiovascular Diseases;cell type;Cells;Cellular Stress;CLC-2 protein;Communication;Country;Data;Dedications;Elderly;extend lifespan;follow-up;Foundations;Future;gamma-Aminobutyric Acid;Gene Expression Profiling;Genes;Genetic;Goals;Health Care Costs;Healthcare Systems;healthspan;Homeostasis;Homologous Gene;Human;human old age (65+);Image;improved;in vivo imaging;infancy;Ion Channel;Ions;knock-down;Knock-out;knockout animal;Life Expectancy;life span;Malignant Neoplasms;Mediating;Medicine;Methods;model organism;Modeling;Monitor;Mus;mutant;Mutate;Nervous System;Neurodegenerative Disorders;Neuroglia;Neuromodulator;Neurons;Nose;novel;Organism;Output;Pathway interactions;Permeability;pH Homeostasis;Pilot Projects;Population;Positioning Attribute;Price;Process;programs;Publishing;Quality of life;Regulation;Research;Resistance;Role;Science;Sensory;Signal Transduction;solute;Stress;Supplementation;Tissues;Touch sensation;transcription factor;transcriptome sequencing;Work

PROJECT_TITLE: Glia in Aging

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]