NIH_SPENDING_CATS: Genetics;Kidney Disease;Pediatric

ORG_STATE: MA

PHR: This research will help understand the molecular basis for two rare skeletal diseases - Jansen's Metaphyseal Chondrodysplasia (JMC) and Eiken Syndrome (ES) - that are caused by PTH/PTHrP receptor (PTH1R) mutations. The proposed research will build upon our in vitro findings showing how JMC- and ES-PTH1R mutants impact cellular mechanisms. We have furthermore generated mouse JMC and ES models to explore the impacts of the disease-causing PTH1R mutations on bone growth and kidney function, and to test new peptides and other compounds as potential therapies for these and possibly related disorders of bone and kidney physiology.

PI_NAMEs: GARDELLA, THOMAS J;JUEPPNER, HARALD W. (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Ablation;Adult;Advanced Development;Affinity;Age;Agonist;Alleles;ARRB2;Binding;Biological;Biology;Blood;bone;Bone Diseases;Bone Growth;Bone plates;C-terminal;Chondrocytes;Chronic Kidney Failure;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Defect;Deformity;Development;Differentiation and Growth;Disease;Epiphysial cartilage;Exhibits;experimental study;Fetus;Gene Mutation;Genetic;GTP-Binding Protein alpha Subunits, Gs;HDAC4 gene;Heterozygote;Homeostasis;hormone resistance;human disease;Hypercalcemia;hypercalciuria;Hypocalcemia;Impairment;in utero;In Vitro;in vivo;Infusion procedures;inhibitor;Injections;insight;Ions;Kidney;Knock-in Mouse;Life;Ligands;Maps;Membrane;Metaphyseal chondrodysplasia;Metatarsal bone structure;Minerals;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Nephrocalcinosis;novel;overexpression;Parathyroid Hormone Receptor;parathyroid hormone-related protein;Patients;Peptides;pharmacologic;Phenotype;Phosphorylation;Physiologic calcification;Physiology;Play;postnatal;prenatal;Proliferating;promoter;PTH gene;pup;receptor;receptor binding;Recommendation;Regulation;Renal function;Research;Resistance;Role;Signal Transduction;skeletal;skeletal disorder;Surface;Syndrome;Tail;Testing;Text;Therapeutic Effect;Time;tool;transgene expression;Transmembrane Domain

PROJECT_TITLE: PTH Inverse Agonists as Therapy for Jansens Disease

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The current supply of cholera vaccines is insufficient, and new lower-cost cholera vaccines have been developed to control the disease globally. However, because we lack accurate immunologic tests to gauge cholera vaccine effectiveness (called ‘correlates of protection’) it is unclear how to best evaluate these new vaccines. In this study, we will identify correlates of protection for cholera which are associated with effective immunity, paving the path for the development and licensure of the next generation of cholera vaccines.

PI_NAMEs: HARRIS, JASON B (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Acceleration;Adult;Affect;Age;Agreement;Antibodies;Antibody Response;Antibody titer measurement;Area;arm;authority;Biological Markers;Case/Control Studies;Cessation of life;Child;Cholera;Cholera Vaccine;Climate;Clinical Trials;cohort;Communicable Diseases;Conflict (Psychology);Consensus;cost;Data;Development;Disasters;Disease;disorder control;Dose;Effectiveness;Epidemic;Exposure to;Health;Health Planning Organizations;Human;Immune;Immune response;Immunity;immunogenicity;Immunologic Tests;improved;Individual;Infection;Infrastructure;Knowledge;Licensure;Longitudinal cohort;manufacture;Measures;Mediating;Memory B-Lymphocyte;Modeling;mortality;Mucous Membrane;next generation;novel;novel vaccines;open label;Oral;Participant;Performance;Phase;Predisposition;Prevention;prospective;Randomized;randomized trial;Resources;response;Schedule;Serology;Serum;sex;Speed;Study Subject;Surrogate Endpoint;Surrogate Markers;System;Testing;tool;Typhoid Vaccine;unethical;unvaccinated;Vaccination;vaccine candidate;vaccine development;vaccine effectiveness;vaccine efficacy;vaccine immunogenicity;vaccine trial;Vaccines;Validation;Vibrio cholerae;Vibrio cholerae infection;Vibrio cholerae O1;World Health Organization

PROJECT_TITLE: Vaccine- and infection-derived correlates of protection for cholera

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: PITTSBURGH

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: This proposal develops an acellular therapy for the in vivo regeneration of the mandibular condyle cartilage of the temporomandibular joint using a novel multi-layer scaffold design and biomaterials. The novel scaffold design will be used to recapitulate the native tissue architecture. Furthermore, we have developed a novel clinically relevant injury model for the TMJ in goats, which is used in the proposed studies.

PI_NAMEs: ALMARZA, ALEJANDRO JOSE (contact);TABOAS, JUAN MANUEL

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 4 year old;Adult;Architecture;articular cartilage;Articulation;base;Bilateral;Binding;Biochemical;Biocompatible Materials;Biological Assay;Biological Availability;bioscaffold;BMP2 gene;bone;Bone Regeneration;Cartilage;cartilage degradation;cartilage regeneration;cartilaginous;Cells;Chondrocytes;Chondrogenesis;clinically relevant;condylar cartilage;costal cartilage;Data;Defect;design;Diffusion;ethylene glycol;Family suidae;Fibroblasts;Fibrocartilages;fibula;Functional Regeneration;Gelatin;Goat;Growth;healing;Heparin;Heparin Binding;Hyaline Cartilage;Hydrogels;Implant;implant design;In Vitro;in vivo;in vivo regeneration;Infiltration;Injury;Kinetics;Liquid substance;Mandible;Mandibular Condyle;Mandibular Scaffold;mechanical load;mechanical properties;migration;Miniature Swine;Modeling;Nanoporous;Natural regeneration;novel;osteochondral tissue;Osteogenesis;osteoprogenitor cell;Pain;Pathology;Patients;Perfusion;Periodicity;Permeability;Phenotype;Polymers;Porifera;prevent;progenitor;Property;Publishing;regeneration potential;regenerative;Regenerative research;regenerative therapy;regenerative treatment;Replacement Arthroplasty;scaffold;Shapes;Site;stem cell population;stem cells;subchondral bone;Technology;Temporomandibular Joint;Temporomandibular Joint Disorders;Time;Tissue Engineering;tissue regeneration;Tissues;Transforming Growth Factor beta;treatment effect

PROJECT_TITLE: Polymer Scaffolds for Mandibular Condyle Cartilage Regeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE Surfactant Protein A (SP-A), is an immunomodulatory protein associated with lung disease of prematurity, abnormal vascular growth, and with Retinopathy of Prematurity (ROP); the leading cause of acquired childhood blindness worldwide. However, the mechanisms by which it drives blood vessel growth are unknown. Understanding the function of this protein in normal and pathological contexts is critical to developing novel, rational and safe therapies for preventing and curing neovascular eye diseases.

PI_NAMEs: BHATTI, FAIZAH NAHEED (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;Actins;Address;angiogenesis;Angiogenic Factor;Antibodies;Appearance;Area;Automobile Driving;Blindness;Blood Vessels;C-Type Lectins;Cell division;cell growth;cell motility;Cell Physiology;Cell Proliferation;Cells;Childhood;Complex;Complication;cytokine;Cytoskeletal Modeling;Cytoskeletal Proteins;Cytoskeleton;Data;Development;Disease;effective therapy;Endothelial Cells;Evaluation;extracellular;Eye diseases;Filopodia;Genes;Genetic;Genomics;Goals;Growth;Growth Factor;Human;Hyperoxia;immunoregulation;Impairment;In Vitro;in vivo;Infant;Inflammation Mediators;Inflammatory;Injections;innovation;interest;Intervention;Knowledge;Lasers;Lentivirus;Life;Ligands;live cell imaging;Lung;Lung Diseases;Maps;Mediating;Microscopic;Modality;Modeling;Molecular;Molecular Chaperones;Molecular Target;Muller's cell;Mus;Natural Immunity;neovascular;neovascularization;neurodevelopment;Neuroglia;new therapeutic target;novel;overexpression;Oxygen;Pathologic;Pathway interactions;perinatal development;permissiveness;Phase;Phenotype;Phosphorylation;Physiological;Play;polymerization;Polymers;Post-Translational Protein Processing;Post-Translational Regulation;premature;Premature Birth;Premature Infant;preservation;prevent;Process;Property;protein folding;protein function;Proteins;Proteomics;Pulmonary Surfactant-Associated Protein A;Quality of life;Rattus;receptor;receptor binding;Receptor Cell;Reporting;response;Retina;retinal angiogenesis;Retinal Diseases;Retinopathy of Prematurity;Rodent;Rodent Model;Role;side effect;Signal Pathway;Signal Transduction;Small Interfering RNA;Societies;spatiotemporal;Stimulus;surfactant deficiency;surfactant protein A receptor;Tamoxifen;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Tissues;transcriptome sequencing;transcriptomics;Transgenic Organisms;vascular abnormality;Vascular Diseases;Vascular Endothelial Growth Factors;Vascular Proliferation;Vision;Visual;Visual Acuity

PROJECT_TITLE: Targeting Surfactant Protein A to Prevent Retinopathy of Prematurity

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: Newark

ORG_DEPT: BIOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Public Health Relevance Our study is designed to test the hypothesis that the ammonia detoxifying function of glutamine synthetase suppresses hepatocellular carcinoma development. It will uncover new mechanisms as to how GS expression is regulated, and will provide new insights that lowering ammonia waste burden can be a therapeutic opportunity for mitigating HCC.

PI_NAMEs: ZONG, WEI-XING  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Ablation;Acceleration;Address;Amides;Amino Acids;Ammonia;Ammonium;Anabolism;Automobile Driving;beta catenin;Binding;c-myc Genes;Carbon;cell growth;Cell Survival;Cells;Circulation;Citric Acid Cycle;Clinic;Coupled;Data;design;Development;Distal;Drug Metabolic Detoxication;Enhancers;Enzymes;Event;factor C;Genes;Genetic;Genetic Transcription;Glutamate-Ammonia Ligase;Glutamates;Glutamine;Growth;Hepatocyte;Hexosamines;Histologic;Homeostasis;Hyperammonemia;insight;Liver;liver ablation;liver cancer model;liver function;LoxP-flanked allele;Malignant - descriptor;Malignant neoplasm of liver;Malignant Neoplasms;Mammals;mass spectrometric imaging;Mediating;metabolome;metabolomics;Molecular;mouse model;Mus;Nitrogen;Non-Essential Amino Acid;novel;Nucleotides;Oncogenes;Oncogenic;Pancreas;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Primary carcinoma of the liver cells;Process;Production;public health relevance;Regulation;repaired;Reporting;Role;Source;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Techniques;Testing;theories;Therapeutic;Tissues;TP53 gene;Transaminases;transcription factor;Transcriptional Regulation;transcriptome;translational potential;tumor;tumor growth;Tumor Promotion;tumorigenesis;urea cycle;Vascular blood supply;Vascularization;wasting;Work

PROJECT_TITLE: Glutamine synthetase in beta-catenin driven hepatocellular carcinoma

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: MADISON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE People incarcerated in the United States are disproportionately affected by substance use disorders as well as chronic physical and mental health conditions, yet are known to under-utilize health services during the transition from prisons to communities. Reducing health disparities in this population requires evidence-based strategies to connect recently-incarcerated people to community-based care. This project will conduct a 2-arm randomized clinical trial to test the effectiveness of a protocolized transitional nurse case management intervention initiated prior to release and continuing for 3 months after release with phone-based support.

PI_NAMEs: BURNS, MARGUERITE ELIZABETH;WESTERGAARD, RYAN PATRICK (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Address;Adult;Affect;Ambulatory Care;arm;care coordination;care systems;Caring;Case Management;Case Management Nurse;Cellular Phone;Cessation of life;Characteristics;Chronic;Clinical Trials;Communities;community based care;community living;comorbidity;correctional system;Data;data resource;Data Set;design;diagnostic criteria;Drug user;economic evaluation;Effectiveness;effectiveness testing;effectiveness trial;Employment;evidence base;federal policy;Funding;Future;Goals;Guidelines;Health;health goals;Health Services;Health Services Accessibility;Health system;Healthcare;high risk;Hospitals;Hybrids;Imprisonment;Improve Access;improved;improved outcome;Individual;innovation;Institution;Intervention;Investigation;Jail;Link;Major Mental Illness;Measures;Medicaid;Medical;medically underserved;medically underserved population;Mental Health;Methods;Modeling;mortality;mortality risk;multidisciplinary;National Institute of Drug Abuse;novel;Nurses;Observational Study;Outcome;Outpatient Health Services;Outpatients;overdose death;Participant;Persons;Pharmaceutical Preparations;physical conditioning;pilot test;pilot trial;Policies;policy implication;Population;Premature Mortality;Preparation;Prevalence;prevent;Primary Care;primary outcome;prison population;Prisons;Process;programs;Psyche structure;Public Health;public health relevance;Publishing;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Recording of previous events;Reduce health disparities;reincarceration;relative effectiveness;Research;Research Methodology;Retrospective cohort;Risk;Running;scale up;Scoring Method;secondary outcome;Services;social;socioeconomics;substance use;Substance Use Disorder;syndemic;System;Target Populations;Telephone;telephone based;Testing;Time;treatment as usual;United States;United States Centers for Medicare and Medicaid Services;Visit;Vulnerable Populations;waiver;Wisconsin;Work

PROJECT_TITLE: Health systems innovations for supporting transitions of care for incarcerated people living with substance use disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Immunization;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE AML is the most common acute leukemia but, despite the diffuse use of allogeneic hematopoietic stem cell transplantation (HSCT), it still has the lowest survival rate of all leukemias. Adoptive immunotherapies are currently hampered by the absence of specific targets, most of which are often shared with healthy tissues and thus lead to immunosuppression/toxicity. Here, we will develop new gene editing strategies to generate a “stealth” hematopoiesis that is resistant to immunoglobulin-based drugs/CAR-T cells. Our strategy allows targeting multiple genes essential to leukemia survival, thus poorly amenable to escape mechanisms. It could be rapidly implemented in allogeneic-HSCT protocols currently used as standard treatment for high-risk subtypes of AML, like those with FLT3 mutation/ITD. Moreover, since our selected targets (FLT3, KIT and CD123) are expressed at high levels in a spectrum of several hematologic malignancies, our strategy could provide more efficacious yet less toxic therapeutic options for several blood cancers.

PI_NAMEs: GENOVESE, PIETRO  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Achievement;Acute leukemia;Acute Myelocytic Leukemia;Address;Adenine;Adoptive Immunotherapy;Affect;Allogenic;Amino Acid Substitution;Amino Acids;Antibodies;Antigens;base editing;base editor;bi-specific T cell engager;Binding;Biological Assay;Blood;Bone Marrow Transplantation;CD34 gene;Cells;chimeric antigen receptor T cells;Clinic;Clinical;Cytokine Receptors;Data;Diffuse;disabled;Disease;Down-Regulation;Electroporation;Endowment;Engineering;Engraftment;Enzymes;Epitopes;Essential Genes;Extracellular Domain;FLT3 gene;gene-editing approach;Genes;Genetic Engineering;Genetic Transcription;genome-wide;Goals;Guide RNA;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;High Pressure Liquid Chromatography;high risk;IL3RA gene;immunogenicity;Immunoglobulins;Immunosuppression;Immunotherapy;Impairment;In Vitro;in vivo;in vivo Model;Interferons;KIT gene;Lead;Lentivirus Vector;leukemia;Libraries;Ligands;Malignant - descriptor;Malignant Neoplasms;manufacturing process;Medical;Messenger RNA;metabolic fitness;Modeling;Monoclonal Antibodies;Mutate;Mutation;Myelogenous;Myeloid Cells;Nature;Neoplasms;novel;novel strategies;nucleotide analog;Outcome;Parameter Estimation;patient derived xenograft model;Patients;Pharmaceutical Preparations;Physiological;Population;preservation;Procedures;Prognosis;protein expression;protein function;Protocols documentation;receptor;reconstitution;Regulation;Relapse;research clinical testing;Residual Neoplasm;Resistance;response;risk minimization;Risk Reduction;Sampling;scale up;screening;Specificity;standard care;Standardization;Survival Rate;System;Target Populations;Testing;Therapeutic;Therapeutic antibodies;Therapeutic Monoclonal Antibodies;Time;Tissues;tool;Toxic effect;Transplantation;tumor;Tumor Escape;Validation;Variant;Work;Xenograft procedure

PROJECT_TITLE: Multiplex Epitope Editing to Enable Novel Immunotherapies for Acute Myeloid Leukemia

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: NEW YORK

ORG_DEPT: CHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Drug resistant bacteria pose urgent global health challenges by reducing the effectiveness of antibiotics used to treat infections in humans and animals. The goal of this research is to uncover molecular mechanisms of antibiotic resistance and to design inhibitors as therapeutics against disease-causing bacteria.

PI_NAMEs: TRAASETH, NATHANIEL J. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acute;Adjuvant;Affinity;Animals;Antibiotic Resistance;Antibiotic Therapy;Antibiotic-resistant organism;Antibiotics;Antibodies;Antibody Binding Sites;antibody inhibitor;Bacillus;Bacillus subtilis;Bacteria;Binding;Binding Sites;Biological Assay;Biophysics;Clinic;Clinical;Communities;comparative;Complex;Coupled;Cryoelectron Microscopy;Crystallization;Cyclic Peptides;Cytoplasm;Data;design;Development;Diffuse;Disease;Distant;drug discovery;drug resistant bacteria;Drug Transport;Effectiveness;efflux pump;experimental study;FDA approved;global health;Goals;Gram-Positive Bacteria;Grant;Growth;Head;Hospitals;Human;in vivo;Infection;inhibitor;insight;Local Anti-Infective Agents;Magic;Measurement;Mediating;Membrane Proteins;Microbiology;Modification;Molecular;Molecular Conformation;molecular dynamics;molecular recognition;Mutation;Nature;NMR Spectroscopy;novel;Organic Synthesis;Organism;pandemic disease;pathogen;pathogenic bacteria;Pathologic Processes;Peptidoglycan;peptidomimetics;Pharmaceutical Preparations;Physiological Processes;Protein Engineering;Public Health;Pump;Research;Resistance;resistance mechanism;Sequence Homology;Site;small molecule;Specificity;Speed;Staphylococcus aureus;Structure;Substrate Specificity;synthetic antibodies;System;Testing;Therapeutic;tool;Translating;uptake;Validation;Work

PROJECT_TITLE: Mechanisms of allostery and molecular recognition in efflux pumps

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Rural Health

ORG_CITY: LEXINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE  In the U.S., radon-induced lung cancer accounts for 21,000 deaths annually, yet the disease remains highly preventable by eliminating exposure to the deadly gas. RADAR 2.0 will address community concerns about high lung cancer rates by building capacity for radon mitigation in rural communities and discovering radon risk messaging intended to prompt radon risk reduction behavior. Additionally, we will support public health action by developing an automated report-back website and investigate the soil processes and characteristics to support pre-construction radon risk forecasting and radon resistant new construction policy.

PI_NAMEs: STANIFER, STACY  (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: access disparities;Address;Awareness;Back;Cancer Etiology;cancer risk;Certification;Cessation of life;Characteristics;citizen science;Clinical Trials Cooperative Group;Collaborations;Communication;Communities;community college;cost;County;Data;design;detector;Disease;Education;Educational Curriculum;Environmental Health;environmental tobacco smoke exposure;Exposure to;Faculty;Feedback;Funding;Gases;Geology;Health;health literacy;Home;Incidence;innovation;Intention;Investigation;Kentucky;Lead;Libraries;Malignant neoplasm of lung;Measurement;Minerals;mortality;novel;novel strategies;Participant;Policies;Policy Developments;Policy Maker;Process;programs;Public Health;Radioactive;Radon;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Resistance;Risk;risk prediction;Risk Reduction;Risk Reduction Behavior;Role;Rural;rural area;Rural Community;Sampling;scale up;Soil;Source;Students;success;System;technical college;Techniques;Technology;Testing;theories;tobacco exposure;tool;Training;Translating;uptake;Uranium;usability;voucher;Waiting Lists;web site

PROJECT_TITLE: Radon on the RADAR

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Radiation Oncology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative This proposal seeks to understand mechanisms that contribute to resistance to radiation therapy in aggressive breast cancers and to use the information obtained to improve therapy. The specific focus is neuropilin-2 (NRP2), a specific receptor for vascular endothelial growth factor (VEGF) that has a major role in promoting radiation resistance, and for which specific, inhibitory mAbs are available for clinical use.

PI_NAMEs: MERCURIO, ARTHUR M (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Affinity;Aggressive behavior;aggressive breast cancer;Antioxidants;Binding;Breast Cancer Cell;Breast Cancer Patient;Breast conservation;Buffers;Cell Death Induction;Cells;chemotherapy;Clinical;clinically significant;Collection;Data;DNA Damage;effective therapy;Exhibits;Failure;Gene Expression Profile;Genetic Transcription;Goals;Growth;improved;In Vitro;in vivo;Inter-tumoral heterogeneity;Investigational Drugs;irradiation;Malignant Breast Neoplasm;Mediating;Metabolic;Monoclonal Antibodies;Morbidity - disease rate;mortality;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;Neuropilin-2;Nitric Oxide;Nitric Oxide Synthase;novel therapeutic intervention;Nuclear;Organoids;Oxidative Stress;patient derived xenograft model;Patients;Phenotype;Population;potential biomarker;Production;Property;Proteins;Radiation;Radiation Induced DNA Damage;radiation resistance;Radiation therapy;Radiation Tolerance;Reactive Oxygen Species;receptor;Recurrence;Regulation;Resistance;response;Role;self-renewal;Shapes;side effect;Signal Induction;Signal Transduction;small molecule therapeutics;stem cells;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;therapy resistant;transcription factor;transcriptome sequencing;transcriptomics;triple-negative invasive breast carcinoma;tumor;tumor heterogeneity;Variant;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Mechanisms and Therapy of Radiation Resistance in Breast Cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Maternal Health;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative/Public Health Relevance This trial will evaluate a web-based, system-level intervention that addresses persistent gaps in PMTCT care by facilitating guideline-adherent services to optimize HIV prevention and maternal health. The HIV Infant Tracking System (HITSystem) 2.1 will prospectively follow HIV-positive pregnant women through 6 months postpartum, employing accessible technologies to ensure complete and timely engagement in clinical care, and robust management of maternal viral loads during critical windows for preventing new HIV infections. Such improvements are essential before low resource countries can close the remaining gaps and eliminate mother- to-child transmission of HIV.

PI_NAMEs: KESSLER, SARAH FINOCCHARIO (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: 2 arm randomized control trial;Acquired Immunodeficiency Syndrome;Address;Adoption;AIDS prevention;antenatal;antiretroviral therapy;Appointment;arm;Breast Feeding;Caring;Cessation of life;Childhood;Clinical;clinical care;cost;cost effective;cost effectiveness;cost-effectiveness evaluation;Country;Data;design;Documentation;early pregnancy;effective intervention;Effectiveness;efficacy evaluation;eHealth;Enrollment;Ensure;evidence base;follow-up;Fostering;Goals;Government;Grant;Guideline Adherence;Guidelines;Health care facility;High Prevalence;high risk;HIV;HIV diagnosis;HIV Infections;HIV Seropositivity;Hospitals;Human immunodeficiency virus test;implementation fidelity;improved;Infant;Interruption;Intervention;Kenya;Life;Maintenance;Maternal Health;Measures;medication compliance;Modeling;Monitor;Mother-to-child HIV transmission;Mothers;Online Systems;Participant;patient engagement;patient retention;pediatric human immunodeficiency virus infection;perinatal HIV;Perinatal transmission;pilot test;Postpartum Period;Postpartum Women;Pregnancy;Pregnant Women;prevent;Prevention;prospective;Provider;Proxy;public health relevance;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Regimen;Resources;Sampling;scale up;Schedule;service delivery;Services;Site;standard of care;success;System;Technology;Test Result;Testing;Text Messaging;therapy development;Time;transmission process;Update;uptake;Vertical Disease Transmission;Viral;Viral Load result;Visit;web-based intervention;Woman;World Health Organization

PROJECT_TITLE: Evaluating the HITSystem to Improve PMTCT Retention and Maternal Viral Suppression in Kenya

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Pediatric;Prevention;Substance Misuse;Substance Misuse Prevention;Telehealth

ORG_CITY: GREENSBORO

ORG_NAME: PREVENTION STRATEGIES, LLC

ORG_STATE: NC

PHR: PROJECT NARRATIVE This project will use engage key stakeholders in designing and iteratively optimizing an online substance use intervention for high school seniors. The optimized behavioral intervention then can be readily adopted by high schools across the US to prevent and reduce substance use and related negative consequences among both college students and nonstudent young adults. In addition, project results will (1) indicate which strategies effectively change mediators, (2) test several novel intervention strategies (i.e., using normative education to change norms about other behaviors linked to substance use; targeting anticipatory socialization); and (3) identify individual and contextual factors that moderate component efficacy, paving the way for more effective, efficient, and potentially tailored interventions.

PI_NAMEs: RULISON, KELLY LIN (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent and Young Adult;adolescent substance use;Adopted;Age;Alcohols;Behavior;Behavior Therapy;Behavioral;behavioral outcome;Belief;Characteristics;Collaborations;college;contextual factors;critical developmental period;Data Analytics;Data Collection;Decision Making;design;deter alcohol use;Development;driving under influence;drug abuse prevention;efficacy testing;Ensure;Expectancy;experience;follow up assessment;Funding;Future;Goals;graduate school;High Prevalence;high risk;high school;High School Student;human centered design;improved;Individual;Intervention;Intervention Studies;iterative design;Life;Link;Marijuana;marijuana use;Mediating;Mediator;Methodology;Middle School Student;Modeling;multiphase optimization strategy;normative education;novel;online intervention;Population;Population Heterogeneity;pressure;Prevention;preventive intervention;Procedures;Process;Professional counselor;Public Health;Randomized;Recording of previous events;recruit;reduced substance use;Research;Research Personnel;Schools;Science;Shapes;skills;social;social influence;Social Network;Socialization;stress management;Students;substance use;substance use prevention;success;Testing;theories;Time;timeline;Tobacco;Tobacco use;twelfth grade;United States National Institutes of Health;universal prevention;university student;vaping;Work;young adult

PROJECT_TITLE: Preventing Drug Use Onset and Progression toward Addiction during a CriticalTransition Period: Optimizing an Online Intervention for High School Seniors

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Contraception/Reproduction;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Organ Transplantation;Transplantation

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Ensuring appropriate utilization of deceased donor kidneys and preventing needless discards of usable kidneys requires expert pathologist interpretations of preimplantation kidney biopsies, but expert kidney pathologists are often unavailable in real time and biopsy interpretations from on-call general pathologists are unreliable and inconsistent. We will apply innovative artificial intelligence (AI) techniques to the interpretation of preimplantation kidney biopsies, and we will link biopsy data with national transplant recipient registry data to develop and validate predictive models of key post-transplant outcomes. Further, we will study attitudes of key stakeholders and catalog facilitators and barriers to implementation of AI-assisted preimplantation biopsy interpretation, to encourage rapid clinical adoption of this technology which could increase transplants, improve outcomes, and assist kidney transplant providers and patients in evaluating the 50,000 kidneys recovered for potential transplantation per year.

PI_NAMEs: GRAMS, MORGAN ERIKA;SEGEV, DORRY L. (contact);TSIRIGOS, ARISTOTELIS

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Adoption;Artificial Intelligence;Atlases;Attitude;Biopsy;Catalogs;Categories;Characteristics;Clinical;clinical decision-making;clinical practice;clinical predictors;clinically relevant;cohort;Communities;Consensus;Data;data registry;Data Set;deep learning;delayed graft function;Delphi Study;design;Development;digital imaging;Dissemination and Implementation;Ensure;Evaluation;experience;Face;Geography;Gifts;gradient boosting;graft failure;graft function;high risk;Histopathology;Image;image archival system;implementation barriers;improved;improved outcome;Individual;innovation;International;Intervention;Interview;Intuition;Kidney;kidney biopsy;Kidney Transplantation;Learning;Left kidney;Life;Link;Measures;Michigan;Modeling;Modernization;mortality;New York;novel;Organ;Organ Procurements;Outcome;Pathologist;Pathology;Patients;Perception;Performance;Phenotype;Population;post-transplant;predictive modeling;preimplantation;prevent;Provider;Reporting;Right kidney;Role;self supervised learning;South Carolina;standard of care;supervised learning;System;Techniques;Technology;Time;tool;Training;training data;transplant centers;Transplant Recipients;Transplant Surgeon;Transplantation;usability;Waiting Lists

PROJECT_TITLE: Optimizing Preimplantation Kidney Transplant Biopsy Interpretation with Artificial Intelligence Assistance  - Resubmission - 1

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Project Narrative: The study of proteins that modulate adipocyte gene expression and function has produced significant advances in our understanding of obesity and Type 2 diabetes. Our proposed studies aim to elucidate the roles of adipocyte KAT8 in regulating adipose tissue function and systemic metabolic health.

PI_NAMEs: STEPHENS, JACQUELINE M (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Ablation;Acetyltransferase;adipocyte biology;Adipocytes;adiponectin;Adipose tissue;Adult;Affect;Antibiotics;Antioxidants;Apoptosis;Autophagocytosis;Basic Science;Body mass index;Body Weight;Brown Fat;cancer type;Cardiovascular Diseases;Cell Nucleus;Cell Physiology;Cells;ChIP-seq;Coupled;Data;Development;Disease;DNA Repair;Electron Spin Resonance Spectroscopy;Endocrine;Endothelium;Fatty acid glycerol esters;Female;Free Radicals;Functional disorder;Gene Expression;gene function;Gene Targeting;Generations;Genes;Genetic study;genome wide association study;Genomics;glucose metabolism;Health;Heterozygote;High Fat Diet;Histones;Homeostasis;Hydrogen Peroxide;Hypertension;Immune;Impairment;in vivo;Industrialization;insight;Insulin Resistance;insulin sensitivity;Knock-out;Link;lipid biosynthesis;Lipids;Lipoatrophy;Lysine;male;Measurement;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Modeling;Molecular;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Pathway interactions;Physiology;Population;Predisposition;prevent;Production;Proteins;Reactive Oxygen Species;Regulation;Repression;Risk Factors;Rodent Model;Role;single nucleus RNA-sequencing;subcutaneous;Superoxides;Testing;Tissues;tumorigenesis;United States;Visceral

PROJECT_TITLE: Elucidating the roles of adipocyte KAT8 in lipoatrophy and systemic insulin resistance

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE: The proposed research will reveal how Insulin-like growth factor 2 mRNA-binding proteins (IMPs) contribute to neuronal temporal fating and further elucidate their roles in stem cell behavior. Knowledge of endogenous neuronal cell fating mechanisms is needed for cell replacement therapies to treat neurological disorders. Moreover, IMPs are upregulated in cancer cells, correlating with poor prognosis; our results may help reveal new therapeutic strategies.

PI_NAMEs: LEE, TZUMIN  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Adult;Antibodies;Binding;Binding Proteins;Biological Models;Birth Order;Brain;cancer cell;cell age;cell behavior;cell replacement therapy;Cell Separation;Cells;Code;Communities;Complement;Complex;Confocal Microscopy;Couples;CRISPR/Cas technology;Data;Development;developmental genetics;Drosophila genus;Electroporation;Epithelial Cell Aggregation and Separation;experimental study;fly;Foundations;Gene Expression;Genes;Genetic;Genetic Code;genetic signature;Goals;Homologous Gene;in utero;innovation;insight;Insulin-Like Growth Factor II;Knowledge;Label;Lateral;Lobe;Malignant Neoplasms;Mammals;Maps;Messenger RNA;Modeling;Molecular;Molecular Genetics;Morphology;Mus;Mutation;Neocortex;neocortical;nerve stem cell;Nervous System Disorder;neurogenesis;neuron development;Neurons;Newborn Infant;notch protein;novel therapeutic intervention;overexpression;Pattern;Periodicals;progenitor;Prognosis;Proteins;Recurrence;Reporter;Research;Resolution;Resources;RNA Interference;RNA-Binding Proteins;Role;Science;Signal Transduction;single cell analysis;single-cell RNA sequencing;Source;Specific qualifier value;Stains;stem cells;Temporal Lobe;temporal measurement;Testing;Time;tool;transcriptome;transcriptomics;Visualization

PROJECT_TITLE: Mechanisms of Neuronal Temporal Fate

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Current medications for the treatment of neuropathic pain are only marginally effective and suffer from serious, sometimes life-threatening, side effects. Inhibiting the activity of the α9α10 nicotinic acetylcholine receptor is emerging as a promising strategy to treat neuropathic pain; however, technical challenges have limited the investigation of this receptor and prevented the discovery of drugs that target it. This project overcomes this historical hurdle in α9α10 drug discovery to identify novel α9α10 antagonists and provide strong evidence to support their future development into new treatments for neuropathic pain.

PI_NAMEs: PETERS, CHRISTIAN ;RILEY, ANDREW  (contact);WANG, ZAIJIE JIM

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Absence of pain sensation;Acetylcholine;addiction;Address;Adult;Adverse effects;Affect;Afferent Neurons;Agonist;allodynia;American;Analgesics;analog;Animal Model;antagonist;Attenuated;Automobile Driving;Behavioral Model;Binding;Biological Assay;Biological Models;Biology;cell immortalization;Cell Line;Cell surface;Cells;Chemicals;chronic pain;chronic pain patient;Clinic;clinical translation;Collection;design;Development;Disease;drug discovery;drug repurposing;Drug Targeting;Drug usage;druggable target;effectiveness evaluation;Electrophysiology (science);Encapsulated;Engineering;Evaluation;Exhibits;Extracellular Domain;Family member;Freund's Adjuvant;Functional disorder;Future;General Population;Genetic;Goals;Health;high risk;high throughput screening;Homology Modeling;Hyperalgesia;Hypersensitivity;in vivo;Injury;innovation;Investigation;Ion Channel;Knock-out;Knockout Mice;Knowledge;Left;Lesion;Life;Ligand Binding Domain;Ligands;Ligation;Location;Macrophage;Mammalian Cell;Membrane Proteins;Molecular Biology;mouse model;Mus;Nervous System;Nicotinic Receptors;non-opioid analgesic;novel;novel drug class;Opioid;Opioid Analgesics;Paclitaxel;Pain;pain inhibition;Pain management;pain model;painful neuropathy;Peripheral;Peripheral Nervous System Diseases;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physical Dependence;Play;pre-clinical;Prevalence;prevent;Property;Proteins;receptor;receptor expression;Research;Research Project Grants;Role;side effect;small molecule;somatosensory;Source;Spinal Ganglia;Spinal nerve structure;spontaneous pain;stable cell line;stoichiometry;Structure;Structure-Activity Relationship;System;Techniques;Testing;Translating;translational potential

PROJECT_TITLE: α9α10 Nicotinic Acetylcholine Receptors in neuropathic pain

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Sepsis is estimated to cause 20% of deaths worldwide, though we have a poor understanding of sepsis and no effective treatments. Our understanding of sepsis is limited by both improper collection of blood samples and ambiguous clinical phenotyping. This project addresses both of these problems by 1) improving the quality of blood collected from sepsis patients that prevents artifactual oxidation during specimen collection and storage, and 2) linking molecular data including those associated with redox immunometabolism to clinical sepsis phenotypes. These blood samples, molecular and clinical data will provide researchers with new tools to find effective treatments for sepsis.

PI_NAMEs: FILES, DANIEL CLARK;FURDUI, CRISTINA MARIA (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: acute care;Address;Affect;Age;Biochemistry;Bioinformatics;Biological Markers;Biology;Blood;blood fractionation;Blood Preservation;Blood specimen;Blood Specimen Collection;Caring;Cell Membrane Permeability;Cells;Cessation of life;Chemicals;Clinical;clinical care;Clinical Data;clinical diagnosis;clinical phenotype;Clinical Trials;cohort;Collection;Critical Care;Critical Illness;Cryopreservation;Cysteine;Data;Data Analytics;Data Set;data warehouse;Dependence;design;Development;Disease;Disease Progression;effective therapy;Electrons;Enrollment;Ethnic Origin;Formulation;Freezing;Future;Gender;Human;improved;Individual;Injury;innovation;Institution;interest;Laboratories;Legal patent;Link;Mass Spectrum Analysis;Measurement;Mediator;Medicine;Metabolism;Methods;Modeling;Modification;Molecular;molecular marker;Multiomic Data;new therapeutic target;Organ failure;Outcome;oxidation;Oxidation-Reduction;Patients;Performance;Peripheral Blood Mononuclear Cell;Phase;Phenotype;Physiological;Pilot Projects;Plasma;Predisposition;preservation;prevent;Prevention;Procedures;Process;prospective;Proteins;Race;Reaction;Reactive Oxygen Species;Reagent;Recovery;Research;Research Personnel;response;sample collection;Sampling;scale up;Sepsis;septic patients;sex;single cell technology;single-cell RNA sequencing;Site;small molecule;Specimen;Staging;standard of care;Technology;Testing;therapeutic development;Time;tool;trial design;Work

PROJECT_TITLE: Redox Trapping for Biospecimen Preservation and Innovation in Sepsis Care

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Lung;Lung Cancer;Mental Health;Networking and Information Technology R&D (NITRD);Nutrition;Physical Activity;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE This project will develop, test, apply, and disseminate new features for multilevel statistical models and software to estimate effects of intraindividual means, variances, slopes of time-varying variables on cancer control outcomes using intensive longitudinal data collected over much longer periods than the typical single burst design. The results will make notable methodological and substantive contributions for the analysis and application of intensive longitudinal data cancer control research. Given the enormous health burdens imposed by cancer, such information could be of significant value to efforts to improve public health.

PI_NAMEs: DUNTON, GENEVIEVE FRIDLUND;HEDEKER, DONALD  (contact)

PROGRAM_OFFICER_NAME: JENSEN, ROXANNE ELAINE

PROJECT_TERMS: Accelerometer;Address;Affect;Age;American;Area;Asthma;Behavior Control;Behavioral;behavioral and social science;Body Weight;Cancer Control;Cancer Control Research;cancer risk;Child;Chronic Disease;Cognition;Complex;Computer software;Data;Data Analyses;Data Set;Death Rate;density;design;Deterioration;Disease;Eating Disorders;Ecological momentary assessment;Educational workshop;emerging adult;emerging adulthood;Environmental Exposure;Epidemiology;Exercise;Feeling;Generations;Grant;graphical user interface;Health;Health behavior;Health Benefit;Heart Diseases;Heavy Drinking;HIV risk;Hour;Hypersensitivity;improved;Individual;insight;Interview;lifetime risk;longitudinal analysis;Malignant Neoplasms;Measurement;medication compliance;Mental Health;Methodology;Methods;mobile sensing;Modeling;Modification;Moods;mortality;multilevel analysis;Nature;next generation;novel;nutrition;Outcome;Participant;Persons;Physical activity;physical inactivity;programs;Public Health;Research Design;Research Personnel;Risk Behaviors;Running;Sampling;secondary analysis;Self-Injurious Behavior;sensor;Series;Sleep;smart watch;Smoking;social;software development;Statistical Models;Structure;Suicide prevention;symposium;Techniques;Testing;Time;Time Study;Tobacco;usability;web site;webinar;Work

PROJECT_TITLE: Novel Statistical Models for Intensive Longitudinal Analyses of Cancer Control Behaviors

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: MINNEAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE RNA is central to numerous biological processes that impact human health. In this work, we will develop new tools to enable fluorescent visualization of RNA. Thus, this project will transform our ability to study RNA in living organisms.

PI_NAMEs: ENGELHART, AARON E. (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Address;Affinity;Animals;aptamer;aqueous;Benchmarking;Bile Pigments;Bilirubin;Biliverdine;Binding;Biological Models;Biological Process;Biology;Broccoli - dietary;Cell Physiology;Cells;cellular imaging;Color;Complex;Culture Media;Development;DNA;Dyes;Exhibits;experimental study;Fluorescence;fluorescence imaging;Food;functional group;G-Quartets;Gene Silencing;Genome;Goals;Health;Heme;Human;Image;Imaging Device;Impairment;improved;in vivo;insight;interest;Jellyfish;Knowledge;Label;Libraries;Ligand Binding;Ligands;Light;live cell imaging;Mango - dietary;member;Messenger RNA;Methodology;Molecular;molecular recognition;next generation sequence data;Organism;Oxidative Stress;Penetration;Pigments;Play;pluripotency;Positioning Attribute;Process;Proteins;Research;Ribosomal RNA;RNA;RNA Binding;RNA Folding;Role;sensor;Signal Transduction;Small Interfering RNA;Stains;Structure;success;System;Tartrazine;tool;Toxic effect;Transcript;Translational Regulation;Translations;tumor;Validation;Viscosity;Visualization;Whole Organism;Work

PROJECT_TITLE: Development of new tags for RNA visualization

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Urologic Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative  Our studies use a human model system to investigate the lineage plasticity that frequently accompanies progression to aggressive muscle invasive bladder cancer, and thus has strong translational relevance. The proposed analyses will elucidate the alterations of chromatin landscapes at the single-cell level that occur during luminal-basal plasticity and will provide essential insights into the mechanistic basis of the epigenomic reprogramming that drives this plasticity. Furthermore, our analyses of luminal-basal plasticity will identify novel approaches for increasing response to an antibody-drug conjugate that is currently approved for treatment of locally advanced and metastatic bladder cancer, thereby leading to improvements in therapy.

PI_NAMEs: SHEN, MICHAEL M. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Affect;Antibody-drug conjugates;Back;Bar Codes;base editing;biobank;Bioinformatics;Biological Assay;Biological Models;Bladder Neoplasm;Cell surface;Cells;Chromatin;Clinical;Clonal Evolution;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Computer Analysis;Data;demethylation;Disease;DNA sequencing;Epigenetic Process;epigenomics;FDA approved;Gene Expression;Genes;Genetic Transcription;Genetically Engineered Mouse;histone demethylase;Histone H3;histone methylation;histone methyltransferase;Histones;Human;human model;improved;In Vitro;in vivo;in vivo Model;innovation;insight;interest;Investigation;KDM1A gene;Knock-out;Lysine;Malignant neoplasm of urinary bladder;Mediating;Mediator;member;Methodology;Methylation;Modeling;Molecular;Molecular Analysis;multiple omics;Muscle;muscle invasive bladder cancer;mutant;Mutation;non-muscle invasive bladder cancer;novel strategies;Organoids;Outcome;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Phylogenetic Analysis;Point Mutation;Population;preclinical study;Regulation;response;Role;Sampling;single nucleus RNA-sequencing;single-cell RNA sequencing;synergism;System;translational impact;tumor;tumor progression;Tumor Promotion;tumorigenesis;Xenograft procedure

PROJECT_TITLE: Investigating mechanisms of tumor plasticity in human bladder cancer

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: CAMBRIDGE

ORG_NAME: THYMMUNE THERAPEUTICS, INC

PHR: PROJECT NARRATIVE Patients with athymia have a complete absence of T cells due to the lack of thymus and will die within the first two years of life without thymic replacement. Current therapeutic approaches are not sustainable or reliable leading to long wait times during which time patients continue to suffer from complications associated with immunodeficiency. Thymmune Therapeutics is developing a scalable stem cell-based therapy for patients with athymia.

PI_NAMEs: LIM, BING  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: 22q11.2;3-Dimensional;Activities of Daily Living;Address;Animal Model;Animals;athymia;Autoantigens;Autoimmunity;autoreactive T cell;Biological Assay;Biological Markers;biomarker panel;Bone Marrow;capsule;CD3 Antigens;CD4 Positive T Lymphocytes;CD8B1 gene;cell motility;Cell Therapy;Cells;Cessation of life;Child;Clinic;Clinical;clinical application;Collection;Cytotoxic T-Lymphocytes;Development;differentiation protocol;DiGeorge Syndrome;drug development;Engraftment;epithelial stem cell;experience;experimental study;Generations;Genetic;Harvest;Heart;Helper-Inducer T-Lymphocyte;Immune system;Immune Tolerance;immunodeficiency;Implant;improved;In Vitro;in vivo;in vivo evaluation;induced pluripotent stem cell;Industrialization;insight;Knowledge;Life;Live Birth;Lymphopoiesis;manufacturing scale-up;Measures;Methods;muscle transplantation;Nude Mice;Organoids;Outcome;Patients;peripheral blood;Phase;Phenotype;pluripotent stem cell differentiation;pre-clinical;prenatal;prevent;Procedures;Production;Protocols documentation;Regulatory T-Lymphocyte;Reporting;Reproducibility;Role;scale up;Site;Skeletal Muscle;Small Business Innovation Research Grant;Speed;stem cell differentiation;stem cell function;stem cell therapy;stem cells;Suspensions;System;T-Lymphocyte;Testing;Therapeutic;Thymic epithelial cell;Thymus Gland;thymus transplantation;Time;Tissue Therapy;Tissue Transplantation;Tissues;Transplantation;Wait Time;Work

PROJECT_TITLE: Development of a stem-cell derived thymic cell therapy to treat patients with athymia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-D(10)]


ADMINISTERING_IC: HL

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: NARRATIVE: Repair of the infarcted heart requires timely recruitment and activation of immune and reparative cells. The dynamic changes in the extracellular matrix network play a central role in regulating phenotype and function of infarct cells, acting through binding to the integrins, a family of cell surface receptors that transduce signals, regulating cell behavior. Our proposal examines for the first time the role of integrins in macrophages and fibroblastss infiltrating the infarct, investigates central mechanisms involved in repair, angiogenesis and fibrosis, and dissects the molecular cascades modulated by cell-specific integrin activation.

PI_NAMEs: FRANGOGIANNIS, NIKOLAOS G (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Adult;angiogenesis;Binding;Blood Vessels;Cardiac Myocytes;cardiac repair;cell behavior;Cell Communication;cell growth regulation;Cell membrane;Cell Surface Receptors;Cell Survival;Cells;chemokine;Cicatrix;Collagen;Communication;Cre driver;Data;Deposition;Exhibits;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Family;Fibrin;Fibroblasts;Fibronectins;Fibrosis;Functional disorder;Funding;Gene Expression;Growth Factor;healing;Heart;Heterogeneity;Immune;immune activation;In Vitro;in vitro Assay;in vivo;in vivo Model;Infarction;Infiltration;Inflammation;Inflammatory;inhibitor;Integrins;ITGA5 gene;Knockout Mice;Leukocytes;Ligands;loss of function;Macrophage;Macrophage Activation;Mechanics;Mediating;migration;Molecular;Myeloid Cells;Myocardial Infarction;Myocardium;Myofibroblast;Nature;novel;Paper;Pathway interactions;Pericytes;Phase;Phenotype;Play;preservation;Proliferating;protective effect;Proteins;Publications;receptor binding;Receptor Protein-Tyrosine Kinases;recruit;Regenerative capacity;Regulation;repaired;Research Support;response;restraint;Role;Signal Pathway;Signal Transduction;Testing;Therapeutic;Time;Up-Regulation

PROJECT_TITLE: Chemokines in healing myocardial infarction

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences;Pediatric

PHR: PROJECT NARRATIVE Receiving parental care is essential for appropriate physical, cognitive, and emotional development in infants across species, and failure to care for an infant predisposes an individual to neurodevelopmental and psychiatric disorders. Caregiving behavior is mediated by neural circuits that promote parental bonding with infants. In this grant, we propose to study the neurobiology underlying the expression of pro- and anti-parental behavior in males and females across behavioral states at the circuit, cellular, synaptic, and molecular levels.

PI_NAMEs: AUTRY, ANITA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Affect;Affinity Chromatography;Aggressive behavior;Animal Behavior;Animals;Area;Automobile Driving;Bathing;Behavior;behavior prediction;Behavioral;Behavioral Mechanisms;behavioral phenotyping;Birth;Brain;Candidate Disease Gene;candidate identification;caregiving;Caring;Cells;Child Rearing;Cognitive;Crying;Data;Dedications;Development;differential expression;Dissection;Electrophysiology (science);Emotional;Experimental Designs;experimental study;Exploratory Behavior;Failure;Female;Fiber;flexibility;Foundations;Functional Imaging;Future;Galanin;Gene Expression;Genes;Genetic;genetic manipulation;Grant;Human;Hypothalamic structure;imaging approach;In Situ Hybridization;in vivo;Individual;Infant;Infant Care;Infanticide;Intervention;Investigation;Knowledge;Lactation;Laughter;Link;male;Medial;Mediating;Mental disorders;Molecular;Molecular Target;Mothers;Mus;neglect;neural;neural circuit;neurobiological mechanism;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neuromechanism;Neurons;Neuropeptides;neuroregulation;neurotransmission;offspring;optogenetics;Outcome;Parents;Partner in relationship;Pathway interactions;Pattern;pharmacologic;Photometry;Physiological;Population;Pregnancy;Preoptic Areas;Property;pup;Research;response;Ribosomes;sex;Sex Differences;Social Behavior;Synapses;Synaptic Transmission;Techniques;Testing;transcriptome sequencing;Translating;translating ribosome affinity purification and RNA-sequencing;urocortin;Whole-Cell Recordings

PROJECT_TITLE: Circuit, cellular, and molecular plasticity in hypothalamic microcircuits underlying flexible infant-directed behavior

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Esophageal Cancer;Genetic Testing;Genetics;Human Genome;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE: Considered a precancerous lesion, Barrett’s esophagus rarely evolves into esophageal cancer. This proposal seeks to understand how specific inherited mutations in cancer-predisposing genes alter the genomic characteristics of Barrett’s esophagus prior to the development of cancer.

PI_NAMEs: GALA, MANISH  (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Acceleration;Adenocarcinoma;Adult;Age;Aneuploidy;ATM Gene Mutation;Barrett Esophagus;Bioinformatics;Biological Markers;biomarker development;Boston;BRCA2 gene;BRCA2 Mutation;cancer prevention;Cancer-Predisposing Gene;Cells;Characteristics;Chemoprevention;clinical risk;Copy Number Polymorphism;cost effectiveness;CRISPR interference;Data;design;Development;driver mutation;Dysplasia;Esophageal Adenocarcinoma;Event;Family;gastrointestinal;General Hospitals;General Population;Genes;Genetic;genetic approach;genetic testing;Genome;genome editing;Genomic approach;Genomics;Germ Lines;Germ-Line Mutation;Heterogeneity;Heterozygote;High grade dysplasia;high risk;High-Risk Cancer;Individual;Inherited;innovation;insight;Lesion;Loss of Heterozygosity;Malignant neoplasm of esophagus;Malignant Neoplasms;Massachusetts;Modeling;multidisciplinary;mutant;Mutate;Mutation;mutation carrier;Organoids;Pathogenicity;Pathologist;Patients;personalized approach;Predisposition;premalignant;pressure;Prevalence;prognostication;progression risk;prospective;Prospective cohort;Publishing;Recording of previous events;Research Personnel;Risk;Risk Assessment;Risk Estimate;Risk Factors;Sampling;screening;Seasons;Shapes;Stains;stem cells;Subgroup;Survival Rate;Tissues;TP53 gene;tumor;Universities;Variant

PROJECT_TITLE: Pathogenic Germline Mutations in Barrett's Esophagus

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prescription Drug Misuse;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: The opioid crisis has affected many sectors of the US population, including middle aged adults. Laboratory models of opioid use adolescent and younger adult subjects, but information for the middle-aged adult developmental stage are unknown. These studies will further our understanding of any specific liabilities for opioid addiction that may be associated with middle age.

PI_NAMEs: TAFFE, MICHAEL A. (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Acute;addiction;Adolescence;Adolescent and Young Adult;Adult;Affect;Age;age difference;age effect;Age Months;Age Years;aged;Aging;Animal Model;antinociception;Attention;Behavior;Behavioral;Brain;Cessation of life;Cognitive aging;Communication;Data;Dementia;Development;Dose;Environmental Risk Factor;Epidemiology;Fentanyl;Health;Heroin;heroin use;Human;in vivo;Inhalation;Intravenous;Investigation;Laboratories;Laboratory Rat;life history;life span;Locomotion;Maintenance;Marketing;middle age;Modeling;Morphine;mortality statistics;Neurobiology;nicotine vapor;Nociception;older adult;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid use;opioid use disorder;Oral;Outcome;Overdose;overdose risk;Oxycodone;oxycodone self-administration;Paper;Pharmaceutical Preparations;pharmacologic;Physiologic Thermoregulation;Physiological;Population;postnatal;pre-clinical;prescription opioid;prescription opioid abuse;Publishing;Rattus;Research;resilience;respiratory;Rewards;Risk;Route;Self Administration;social;statistics;Stimulant;Substance abuse problem;synthetic opioid;Training;United States;vapor;young adult

PROJECT_TITLE: Explicating Vulnerability and Resilience in Opioid Self-Administration in Middle Aged Rats


ORG_CITY: STANFORD

ORG_DEPT: ORTHOPEDICS

ORG_NAME: STANFORD UNIVERSITY

PHR: The outcomes from proposed work will facilitate translation of cell membrane coated macroporous scaffolds as a platform technology for enhancing tissue regeneration through immunomodulation. While the proposal will focus on cranial bone regeneration as a model, this technology and can be broadly applied with other cell membrane types and for regenerating various tissue types.

PI_NAMEs: YANG, FAN  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: 3-Dimensional;Acceleration;Age;age effect;aged;Aging;aging population;aging related;Allogenic;Animal Model;animal old age;Animals;Apoptosis;Biocompatible Materials;Biological Assay;Biology;Biomimetics;Blood;bone;bone healing;Bone Regeneration;CD8-Positive T-Lymphocytes;cell age;Cell membrane;Cell model;cell type;Cells;Cephalic;Collaborations;Complex;cytokine;Cytometry;Data;Defect;differentiation in vitro;disease model;Drug Delivery Systems;efficacy validation;Enhancement Technology;Exhibits;Female;first responder;Formulation;Gelatin;Gender;Goals;Gonadal Steroid Hormones;Grant;healing;high dimensionality;Human;Immune;Immune response;Immunology;immunoregulation;Impaired healing;Implant;In Vitro;in vivo;in vivo Model;in vivo regeneration;Individual;Inflammation;Inflammatory;Injury;Joints;Knowledge;Lead;Ligands;Macrophage;male;Mesenchymal Stem Cells;Methods;Modeling;Mus;nanoparticle;nanoparticle drug;nanopolymer;Natural regeneration;old mice;Osteogenesis;Outcome;Paper;Patients;Process;Productivity;Publications;receptor;recruit;regenerative;Regulatory T-Lymphocyte;scaffold;Serum;single cell sequencing;success;T-Lymphocyte;Technology;technology platform;Testing;Tissue Engineering;tissue regeneration;tissue support frame;Tissues;Translations;Validation;Work

PROJECT_TITLE: Cell membrane-coated macroporous scaffolds for enhancing bone regeneration in aging

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative Resting-state (RS) neural activity shows rapid changes across the first years of life (the background against which brain function and behavior emerge), with RS activity in older children and adults indexing the inhibition of task-irrelevant processes, associated with top-down cognitive control processes, central to how local networks process information, and associated with our ability to quickly process information. Our understanding of RS activity in infants and toddlers is limited by challenges that have so far hindered research in this area, with this project making progress via (1) the use of a RS task optimized for infants and toddlers, (2) using recently developed algorithms to more accurately measure RS activity, (3) obtaining measures of RS activity in brain space to test theories associating RS neural activity with brain structure, chemistry, and developmental milestones, and (4) obtaining temporally dense brain measures as understanding brain development requires assessing maturational processes. In this prospective cohort design, brain development and behavior will be examined at baseline in infants 0 to 4 months (N=70) and then longitudinally at 4-month intervals with the final visit at 12 to 16 months (4 visits in total), with finding greatly extending our understanding of infant/toddler resting-state neural activity.

PI_NAMEs: EDGAR, JAMES CHRISTOPHER (contact)

PROJECT_TERMS: Adult;Age;Algorithms;Area;awake;Behavior;Brain;Brain Chemistry;Brain region;Chemistry;Child;Climacteric;Clinical;cognitive control;Darkness;Data;Data Sources;design;Development;Disease;Electrophysiology (science);Equilibrium;Evaluable Disease;experience;Eye;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Glutamates;gray matter;high dimensionality;Human;indexing;Infant;Infant Behavior;Intention;interest;Life;Longitudinal Studies;Magnetic Resonance Imaging;Magnetoencephalography;Measures;Methods;multimodality;neural;neural circuit;Parietal;Periodicals;Process;processing speed;Prospective cohort;rate of change;Readiness;regional difference;Reporting;Research;response;Rest;Sampling;Sleep Stages;Source;source localization;Structure;Task Performances;Testing;theories;Time;Toddler;Variant;Visit;visual stimulus;Walking;white matter

PROJECT_TITLE: Brain structure and function in infants

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ORG_CITY: UTICA

ORG_NAME: MASONIC MEDICAL RESEARCH LABORATORY, INC

PHR: PROJECT NARRATIVE Pulmonary embolism (PE) is the third leading cause of cardiovascular death, with post-PE complications leading to drastic reductions in quality of life and chronic functional limitations, as well as an increased risk of recurrent PE. This proposal will utilize a novel murine model of PE, single nucleus molecular profiling, and longitudinal multiplexed molecular imaging to noninvasively access the contribution of PE size and age on the resultant inflammatory and pulmonary fibrotic response while also quantifying the salutatory effects of fibrinolysis therapy. These findings aim to elucidate novel targets and molecular imaging agents to aid in better diagnosis and stratification of patients with PE.

PI_NAMEs: KESSINGER, CHASE WILLIAM (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Acute;Address;Age;aged;Aging;Anticoagulation;Automobile Driving;bench-to-bedside translation;Binding;Biological;biological age;Biological Markers;Blood Platelets;Brain hemorrhage;Cardiovascular system;Catheters;Cell Communication;Cell Nucleus;Cells;Cessation of life;Chronic;Clinic;Clinical;clinical translation;Coagulation Process;Collagen;Collagen Type I;Cytolysis;deep vein;Deep Vein Thrombosis;Development;Diagnosis;Diagnostic;Distal;Embolism;Endothelium;Epithelium;Exhibits;Female;Fibrin;Fibrinolysis;Fibroblasts;Fibrosis;fibrotic lung;glucose uptake;Goals;heart function;hemodynamics;Hemorrhage;high risk;Hour;Human;Hypertension;Image;image translation;imaging agent;improved;in vivo;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;Injury;Investigation;Link;Lobe;Location;Lung;lung lobe;Macrophage;male;Measures;Medical;Modeling;Molecular;molecular imaging;Molecular Profiling;mouse model;Mus;Myocardial Infarction;neutrophil;novel;Outcome;Pathogenesis;Patient Selection;patient stratification;Patients;pre-clinical;Process;Publishing;pulmonary arterial pressure;Pulmonary Embolism;Pulmonary Fibrosis;Pulmonary Hypertension;Quality of life;Recurrence;Reporting;Research;residence;Resolution;response;Right Ventricular Function;Risk;risk stratification;Shock;single nucleus RNA-sequencing;Stroke;Syndrome;targeted imaging;Testing;Therapeutic;Therapeutic Embolization;Thrombin;thrombogenesis;Thrombolytic Therapy;Thrombus;Time;Transgenic Mice;Translations;Validation;Venous;Venous Thrombosis;Work

PROJECT_TITLE: Molecular and morphometric imaging of coagulation and inflammation in pulmonary embolism pathogenesis

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Before you can see the retina produces neural activity that guides development of the brain’s visual system. This project will explore how the cortex and the thalamus work together to actively transform this input to a form uniquely suited for early visual maturation, using a rodent model of fetal brain development. Our long- term objective is to understand the special role that fetal rhythms play in the maturation of vision, to be able to identify and treat consequences of preterm birth and perinatal brain injury such as cerebral visual impairment.

PI_NAMEs: COLONNESE, MATTHEW TODD (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Adult;Animals;Axon;Biological Assay;Birth;Brain;Brain Hypoxia-Ischemia;Cell Nucleus;cell type;cerebral visual impairment;Chronic;Complex;Data;delivery complications;density;designer receptors exclusively activated by designer drugs;Development;Early Diagnosis;Electroencephalography;Elements;experimental study;Eye;Feedback;fetal;Funding;gain of function;Genetic;Growth;human fetal brain;human model;Hypoxia;Individual;infancy;insight;Knowledge;loss of function;Measures;Modeling;Mus;Neonatal;neonatal brain;neonatal mice;neural;Neurodevelopmental Disorder;Neurons;neuroregulation;novel;optogenetics;Outcome;Pathway interactions;Perinatal Brain Injury;Play;Predisposition;Premature Birth;Property;pup;regeneration potential;response;Retina;Rodent;Rodent Model;Role;Seizures;Sensory;Structure;Synaptic plasticity;Testing;Thalamic structure;Translating;transmission process;Viral;Vision;Vision Disorders;Visual;Visual Cortex;Visual impairment;visual map;Visual Pathways;Visual System;Visualization;Work

PROJECT_TITLE: Circuit specializations of developing visual networks


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Ewing sarcoma is a highly malignant bone tumor with poor outcomes for patients with relapsed or metastatic disease. We have identified that PAK4 contributes to Ewing sarcoma development and metastasis, and we propose to further understand the mechanistic role of PAK4 through dissection of its direct downstream signaling networks and role as a novel regulator of alternative splicing. Finally, we will validate PAK4 as a novel therapeutic target for high-risk Ewing sarcoma in combination with chemotherapy and other targeted agents, which is relevant to public health and the NIH's mission because understanding and validating new therapeutic targets for pediatric sarcomas will improve patient survival while minimizing toxic effects of current therapy.

PI_NAMEs: DASGUPTA, ATREYI ;YUSTEIN, JASON  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Address;Adult;Alternative Splicing;anti-cancer;Automobile Driving;Biological Assay;Biology;Bone neoplasms;CDK4 gene;Cell model;Cell Physiology;Cells;chemotherapy;Childhood;childhood sarcoma;clinical application;Clinical Treatment;Clinical Trials;clinically relevant;Combined Modality Therapy;Complement;Cytoplasm;Cytotoxic Chemotherapy;Data;Development;differential expression;Disease;Dissection;Drops;Drug resistance;effective therapy;efficacy evaluation;Evaluation;Event;Ewings sarcoma;Family;FLI1 gene;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Goals;high risk;improved;In Vitro;in vivo;in vivo evaluation;inhibitor;innovation;insight;Institution;Knock-out;Knowledge;Laboratories;Ligation;Link;lung metastatic;Malignant Bone Neoplasm;MAP Kinase Gene;Mass Spectrum Analysis;Mediating;Metastatic Ewing's Sarcoma;Mission;Modeling;Molecular;mutant;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutic intervention;Nuclear;Oncogenes;Oncogenic;Operative Surgical Procedures;overexpression;p21 activated kinase;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;phosphoproteomics;Phosphotransferases;PIK3CG gene;Population;pre-clinical;preclinical evaluation;Property;Protein Isoforms;Protein Kinase;protein protein interaction;Protein Splicing;Protein-Serine-Threonine Kinases;Proteins;proteogenomics;Public Health;Radiation;rational design;real time monitoring;Regimen;Relapse;Reporter;Reporting;resistance mechanism;RNA Splicing;Role;Sampling;Secondary to;selective expression;Serine;Signal Transduction;Slide;SN-38;Solid Neoplasm;Specimen;Spliceosomes;Survival Rate;targeted agent;targeted treatment;Therapeutic;Tissue Banks;Tissue Sample;Toxic effect;transcription factor;Transcriptional Regulation;transcriptomics;Translating;Treatment Protocols;tumor;United States National Institutes of Health;Validation

PROJECT_TITLE: Dissecting and targeting PAK4 in Ewing sarcoma

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PUBLIC HEALTH RELEVANCE STATEMENT This study examines how adhesive factors on the cell surface of the oral colonizer Actinomyces oris are built and mediate bacterial interactions leading to formation of dental plaque. The results generated may provide novel strategies for the prevention, control, and treatment of dental plaque-related diseases.

PI_NAMEs: TON-THAT, HUNG  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Actinobacteria class;Actinomyces;Adhesives;Affect;age group;antagonist;Bifidobacterium;Biochemical;C-terminal;Candidiasis;Cell surface;cell type;Cell Wall;Complex;Corynebacterium;Corynebacterium diphtheriae;Defect;Dental;Dental Enamel;Dental Plaque;Development;Disadvantaged;Disease;Economic Burden;Ectopic Expression;effective therapy;Electrons;Enzymes;Excretory function;Experimental Models;extracellular;Genes;Genetic;Gingivitis;Goals;Gram-Positive Bacteria;Grant;Growth;Homeostasis;Homologous Gene;Housekeeping;Human;Infection;Integral Membrane Protein;Link;Mediating;Membrane;Membrane Proteins;Methods;Microbial Biofilms;microbial community;Microscopic;Modeling;molecular assembly/self assembly;Morphogenesis;Morphology;mouse model;mutant;Names;novel;novel strategies;Odontogenesis;Oral;oral biofilm;Oral cavity;oral pathogen;Pathogenesis;Peptidyltransferase;Periodontitis;Pilum;Play;polymicrobial biofilm;Population;Porphyromonas gingivalis;prevent;Prevention;Prevention strategy;Property;Proteins;Proteolytic Processing;public health relevance;Research;Role;signal peptidase;Signal Transduction;sortase;stoichiometry;Surface;targeted treatment;Testing;tooth surface;Virulence

PROJECT_TITLE: Molecular Assembly on the Cell Surface of Actinomyces

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Microbiome;Nutrition

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: The human gut microbiota is a diverse collection of microbes crucial to our health and well- being. This proposal seeks to both define whether one specific metabolite present in our gut, in combination with our diet, shapes the composition of a very important group of bacteria critical to our health and whether these bacteria in turn affect the levels of this metabolite which has profound impacts on our health. These studies will be instrumental toward efforts to develop interventions to shape the composition and function of our gut microbiome to promote health and treat a wide variety of diseases.

PI_NAMEs: RAKOFF-NAHOUM, SETH  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Acyl Coenzyme A;Address;Affect;Bacteria;Bacteroides;Bacteroides fragilis;Basic Science;Butyrates;carcinogenicity;Cataloging;Cells;Clinical;Collection;Colon;Colon Carcinoma;Communities;Complex;Data;Diabetes Mellitus;Diet;dietary;Disease;Ecology;Engineering;extracellular;Feces;fitness;Genes;Genetic;Gnotobiotic;Goals;Gram-Negative Bacteria;gut bacteria;gut microbes;gut microbiome;gut microbiota;Health;Health Promotion;Homeostasis;host-microbe interactions;Human;human disease;Human Microbiome;Immune;in vivo;Intervention;Link;Mediating;member;Metabolic;Metabolism;Metabolite Interaction;Microbe;microbial;microbiome;microbiome components;Mission;Molecular;mouse model;National Institute of Allergy and Infectious Disease;National Institute of Diabetes and Digestive and Kidney Diseases;Nerve Degeneration;Pathogenicity;Personal Satisfaction;Physiology;Play;Polysaccharides;prebiotics;Prevention;Production;Publishing;Resistance;Role;Shapes;Source;Structure;sugar;Testing;therapy development;translational applications;Work

PROJECT_TITLE: Leveraging glycan-metabolite interactions to shape structure and function of the gut microbiome

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Autoimmune Disease;Immunotherapy

ORG_DEPT: PATHOLOGY

PHR: TCR signaling in thymic selection: Role of innate immune activation Narrative Human autoimmune disease arises from failures of tolerance induction in the thymus. This proposal will study a fundamental property of how tolerance is induced in the thymus, namely the role of innate immune activation of antigen presenting cells.

PI_NAMEs: HOGQUIST, KRISTIN A. (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Adopted;Antibody Response;Antigen Presentation;Antigen Presentation Pathway;Antigen-Presenting Cells;Antigens;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactivity;B-Cell Activation;B-Lymphocytes;Biological Assay;BLR1 gene;CASP3 gene;Cell Count;Cells;cytokine;Data;deep sequencing;Defect;Dendritic Cells;Development;Ensure;Environment;Failure;gene product;Genetic Transcription;Human;humoral immunity deficiency;Immune;immune activation;Immune response;Immunize;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;Infection;Infiltration;Inflammation;Innate Immune Response;Interferon alpha;Interferons;Licensing;Life;Mus;neonatal mice;Nude Mice;Pathology;Pathway interactions;Peptides;Peripheral;Phenotype;Play;prevent;Property;Proteins;Publishing;Reaction;receptor;reconstitution;Regulatory T-Lymphocyte;Reproducibility;Research;Role;Self Stimulation;Signal Transduction;Source;Structure of germinal center of lymph node;T cell receptor repertoire sequencing;T-Lymphocyte;Testing;Thymic epithelial cell;thymocyte;Thymus Gland;Tissues;TNFRSF5 gene;TNFSF5 gene;Up-Regulation;wound healing

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Pulmonary arterial hypertension (PAH) is a progressive condition characterized by uncontrolled pulmonary vascular cell proliferation that ultimately leads to right heart failure and death. In this proposal, we will uncover novel mechanisms that are involved in hemolysis-mediated pulmonary vascular remodeling. This work may provide important new answers to the question of why hemolytic patients have a higher susceptibility to PAH and may lead to the discovery of new, more targeted therapeutics for this incurable disease.

PI_NAMEs: RAFIKOV, RUSLAN  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Affect;angiogenesis;Binding;Blood capillaries;Cell Proliferation;Cell Separation;Cells;Cessation of life;cytokine;Cytosol;Data;Disease;efficacy evaluation;Endothelial Cells;Endothelium;Epithelial Cells;Functional disorder;General Population;Genes;genetic signature;Heart;Heme;heme a;Hemolysis;Heterogeneity;Homologous Gene;Human;Immune response;Impairment;Individual;Inflammation;inhibitor;Knowledge;Lung;Lymphatic Endothelium;Macrophage;Maintenance;Mediating;Mitotic;Modeling;Molecular;Names;novel;overexpression;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Peptides;Phosphotransferases;Population;Pre-Clinical Model;Predisposition;Prevalence;Production;Proliferating;Property;Proteins;pulmonary arterial hypertension;Pulmonary Hypertension;pulmonary vascular cell proliferation;pulmonary vascular remodeling;Research;response;right ventricular failure;Role;sensor;Severities;Sickle Cell Anemia;Signal Transduction;Structure of parenchyma of lung;targeted treatment;Testing;Thalassemia;Therapeutic;Vascular remodeling;Venous;Work;Yeasts

PROJECT_TITLE: Hemolysis and Free Heme Signaling in Pulmonary Hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-M (03)]


ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Although obesity develops at a similar rate for both sexes, the biology underlying excessive weight gain in men and women is thought to be substantially different. While a dysregulated hypothalamic neural network critically contributes to the development of obesity, the intraneuronal signaling mechanisms underlying sex-specific control of body weight remain vague. The proposed research seeks to identify a critical hypothalamic signaling pathway that affects metabolic homeostasis in a sex-specific manner.

PI_NAMEs: CUI, HUXING  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Adenylate Cyclase;Adult;Affect;Animals;Behavior;Binding;Biology;Body Weight;cancer type;Cell Nucleus;Characteristics;ChIP-seq;Chronic Disease;Cilia;Coupled;Cyclic AMP;Data Set;design;Development;Diabetes Mellitus;diet-induced obesity;Disproportionately impacts women;Eating;Electrophysiology (science);energy balance;Energy Metabolism;ESR1 gene;estrogenic;Estrogens;excessive weight gain;Exhibits;Expenditure;Female;gain of function;Genes;Genetic study;Genetic Transcription;Glutamates;GTP-Binding Protein alpha Subunits, Gs;High Fat Diet;Homeostasis;Human;Human Genetics;Hypertension;Hypothalamic structure;Image;Impairment;in silico;in vivo;insight;Knockout Mice;Knowledge;Life;Literature;loss of function mutation;Mammalian Cell;Mediating;Melanocortin 4 Receptor;men;Metabolic;Metabolic Control;Molecular;Morbid Obesity;Motor Activity;Mus;Mutation;Nature;neural network;neuronal excitability;Neurons;neurotransmission;neurotransmitter release;Neurotransmitters;novel;novel strategies;Obesity;obesity development;Obesity Epidemic;Organelles;Ovariectomy;overexpression;Physiology;Play;Population;postnatal;prenatal;Presynaptic Terminals;prevent;programs;Promoter Regions;Publishing;receptor;Receptor Signaling;Regulation;Research;Risk Factors;risk variant;RNA Polymerase II;Role;Sensory;sex;Sex Bias;sexual dimorphism;SF1;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Slice;Testing;Tissues;Transcriptional Regulation;transcriptomics;Untranslated Regions;Weight Gain;Woman

PROJECT_TITLE: Uncovering the role of hypothalamic ciliary cAMP signaling in sex-specific control of metabolic homeostasis

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Patients with mental health conditions that affect the functioning of the front of the brain – anterior lateral prefrontal cortex – can experience difficulties with high-level abilities such as reasoning, planning, multi- tasking, judging the accuracy of their memories, and decision-making. We seek to gain mechanistic insights regarding the function and detailed anatomy of this region in humans, through a combination of tightly controlled cognitive tasks and powerful magnetic resonance imaging (MRI) methods. We expect that this theoretically novel and methodologically sophisticated research will advance our understanding of the function of a brain region that is critical for day-to-day life and work in our complex modern world.

PI_NAMEs: BUNGE, SILVIA A. (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Adult;Affect;Anatomy;Animal Model;Anterior;Architecture;Area;Attention;Auditory;Brain;Brain imaging;Brain region;cerebral blood volume;Cognition;Cognition Disorders;Cognitive;cognitive ability;cognitive task;Complex;Data Set;data sharing;Decision Making;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Early Diagnosis;Early identification;Evaluation;experience;Fiber;Functional disorder;Functional Magnetic Resonance Imaging;high resolution imaging;Histologic;Human;Image;imaging modality;Imaging technology;improved;Individual;individual variation;innovation;innovative technologies;insight;Investigation;Label;Lateral;Life;Link;Location;Magnetic Resonance Imaging;Measures;Memory;memory retrieval;Mental disorders;Mental Health;mental representation;mental set;Methodology;Methods;Microscopic;Mission;Modality;Modernization;Monitor;Morphology;multimodality;multitask;National Institute of Mental Health;neural;Neuroanatomy;Neurodevelopmental Disorder;neuromechanism;Neurosciences;Nomenclature;novel;Output;Parietal Lobe;Participant;Patients;Performance;Play;Positioning Attribute;Prefrontal Cortex;Process;Recurrence;Regional Anatomy;Research;Resolution;response;Role;Running;Schizophrenia;Semantics;Sensory;Short-Term Memory;species difference;Stimulus;Structure;Technology;Temporal Lobe;Terminology;Testing;theories;Thinking;Time;Visual;Visuospatial;white matter;Work

PROJECT_TITLE: Narrowing the mechanistic gap for anterior prefrontal cortex function

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Natural Products

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative. We propose a system to drive natural product discovery via correlation of injury response and regulated cell death pathways to hallmarks of antitumor immunity to discover the next generation of leads for therapeutics capitalizing on chemically induced anti-tumor immunity.

PI_NAMEs: BACHMANN, BRIAN O (contact);IRISH, JONATHAN MICHAEL

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Acceleration;adaptive immune response;adaptive immunity;Adjuvant;Anti-tumor Natural Products;Antigen Presentation;Antigen-Presenting Cells;Antigens;Bar Codes;Biological;Biological Assay;Biology;cancer cell;cancer therapy;carcinogenesis;Cell Death;Cell Death Process;Cell Death Signaling Process;cell injury;Cells;Cessation of life;Chemical Agents;Chemicals;Chemistry;chemotherapy;Clinical;clinical application;Cross-Priming;Cultured Tumor Cells;cytotoxic;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Diagnosis;DNA;Engraftment;Equilibrium;Exposure to;Family;Flow Cytometry;Genome;Goals;guided inquiry;Health;Human;Immune;Immunity;Immunize;immunogenic;immunogenic cell death;immunogenicity;Immunologics;immunomodulatory therapies;Immunooncology;Immunotherapy;injured;Injury;Innate Immune Response;Intercalating Agents;Malignant Neoplasms;Maps;Measurement;metabolome;metabolomics;Methods;microbial;Microtubules;Mining;Modality;Molecular;Mus;Natural Immunity;Natural product discovery;Natural Products;new therapeutic target;next generation;novel;Organism;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Process;Production;Productivity;Property;recruit;Research;response to injury;scaffold;secondary metabolite;Signal Transduction;small molecule therapeutics;Solid Neoplasm;Stimulus;Structure-Activity Relationship;System;T-Cell Activation;T-Lymphocyte;Therapeutic;Toxic effect;Treatment Efficacy;tumor;Tumor Antigens;Tumor Immunity;Validation;Variant;Work

PROJECT_TITLE: Single Cell Methods for Bioeffector Discovery and Analysis

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: CHAPEL HILL

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative In this project, we will leverage the expertise of our team in Magnetic Resonance Fingerprinting (MRF), machine learning, and pulse sequence optimization to develop and optimize a rapid and robust quantitative MR technique, applicable to high-resolution volumetric brain imaging. The high-resolution 3D MRF imaging and reconstruction pipeline to be developed in this project will make quantitative MRI more accessible in clinical settings. We will also develop a cloud-based post-processing pipeline for convenient sharing and setup of our imaging technologies across imaging sites, promoting method validation and clinical translation.

PI_NAMEs: CHEN, YONG ;YAP, PEW-THIAN  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: 3-Dimensional;Acceleration;Brain;Brain imaging;Calibration;Clinical;clinical diagnosis;clinical translation;cloud based;Cloud Computing;cohort;Computers;Consumption;contrast imaging;convolutional neural network;cost;Data;deep learning;density;design;Diagnosis;diagnostic accuracy;Dictionary;Disabled Persons;Disease;empowerment;Fatty acid glycerol esters;Fingerprint;Fourier Transform;Functional disorder;Graph;Image;Image Analysis;image reconstruction;Imaging technology;improved;Machine Learning;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Measures;Methods;Monitor;Morphologic artifacts;Motion;Multiple Sclerosis;multiple sclerosis patient;Nervous System Disorder;novel;open source;Patients;Pattern;Phase;Physiologic pulse;Pilot Projects;Preparation;Property;Protocols documentation;Protons;quantitative imaging;reconstruction;Reproducibility;Research;Resolution;Sampling;Scanning;Signal Transduction;Site;Slice;Techniques;Time;tissue mapping;Tissues;tool;Training;Translations;transmission process;Validation;Visualization

PROJECT_TITLE: Optimized High-Resolution Fast Magnetic Resonance Fingerprinting with Cloud-Based Reconstruction

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative Extensive rearrangement of genomic regions in an individual mediate many diseases but also pose chal- lenges for analysis. In this continuing grant, we develop computational algorithms to explain the complex rearrangements using new genomic technologies. The proposed methods will help detect and explain the pathology of constitutional genetic disorders and somatic DNA lesions observed in cancers.

PI_NAMEs: BAFNA, VINEET  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: 3-Dimensional;Algorithmic Software;Algorithms;Architecture;cancer genome;cell type;Cells;Chromatin;Chromosome Markers;clinical application;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;combinatorial;Combinatorial Optimization;Complex;Computational algorithm;Computer software;Computing Methodologies;Constitution;cost;detection method;Development;Diagnostic tests;Disease;DNA lesion;DNA Repair;DNA Sequence Rearrangement;Dryness;Embryo;Embryonic Development;environmental change;Epigenetic Process;Evolution;experimental study;extrachromosomal DNA;Gene Expression;Gene Expression Regulation;Gene Rearrangement;Genetic;Genetic Diseases;Genome;Genome Mappings;genome-wide;Genomic Segment;genomic variation;Genomics;Genotype;Germ Lines;Goals;Grant;Graph;Haploidy;Hi-C;improved;Individual;insight;Karyotype;Karyotype determination procedure;Malignant Neoplasms;Mediating;Methods;Modeling;Molecular Conformation;mosaic;nano;nanopore;new technology;novel;novel sequencing technology;Optics;Output;Pathologic;Pathology;Pattern;Phenotype;Ploidies;postnatal;prenatal testing;Process;Protocols documentation;Publications;reconstruction;reference genome;Sampling;Shapes;Software Tools;Structure;Technology;Time;Tissues;tool;Tumor Pathology;Variant;Work

PROJECT_TITLE: Computational methods for detecting patterns of complex genomic variation

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Kidney Disease;Patient Safety;Prevention

PHR: Building on our success in the IGNITE research network, we are well positioned to drive the implementation of genomic medicine. Indiana University has clinical and research infrastructure spanning the state of Indiana capable of building upon its existing genomics-enabled learning health system infrastructure and disseminating implementation strategies and tools in partnership with other national sites. We propose to do this in the context of two clinical trials that learn from the health care system pragmatic lessons that will enable broad implementation of genomic medicine across diverse health care settings.

PI_NAMEs: DEXTER, PAUL ;SKAAR, TODD C. (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;African ancestry;APOL1 gene;appropriate dose;Behavior;Bioethics;Cancer Patient;capecitabine;care outcomes;Cessation of life;Charge;chemotherapy;Chronic Kidney Failure;Clinic;Clinical;clinical decision support;Clinical effectiveness;clinical infrastructure;Clinical Trials;Clinical Trials Network;clinically actionable;Communication;Counseling;Country;Data;Data Science;Data Storage and Retrieval;Decision Making;design;Development;Dihydropyrimidine Dehydrogenase;Discipline;discrete data;Disease;Disease Outcome;Dose;Drug Metabolic Detoxication;Economics;Education;Environment;Enzymes;European;Evaluation;experience;Feedback;fluoropyrimidine;Fluorouracil;Funding;Future;Genetic;Genetic Counseling;genetic testing;genetic variant;Genomic medicine;Genomics;Genotype;Goals;Guidelines;Health;health care disparity;health care service;health care settings;Health Resources;Health system;Healthcare;Healthcare Systems;high risk;hypertensive;implementation science;implementation strategy;implementation tool;improved;Indiana;Individual;Informatics;Infrastructure;innovation;insight;Insurance;Intervention;Investments;Joints;Kidney Failure;Knowledge;Laboratories;Leadership;Learning;Life;Logistics;loss of function;Mainstreaming;Malignant Neoplasms;Medical Informatics;medical schools;Medically Underserved Area;Medicine;National Human Genome Research Institute;Nephrology;Oncologist;outcome disparities;outreach;Patient Care;patient education handout;Patients;Pediatrics;Pharmaceutical Preparations;Pharmacogenomics;Pharmacology;Positioning Attribute;Precision Health;Process;Productivity;programs;prospective;Provider;Randomized;randomized, clinical trials;Rare Diseases;recruit;Reporting;Research;Research Infrastructure;Resolution;Resources;Risk;Risk Factors;Risk Management;scaffold;Site;standard of care;success;Test Result;Testing;testing uptake;tool;Toxic effect;Underserved Population;United States National Institutes of Health;Universities;uptake;Variant;willingness;Work

PROJECT_TITLE: Implementing a genomics-enabled Learning Health System across Indiana

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (M1)]