NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Heart failure affects 5 million American adults and children and accounts for more hospitalizations than all forms of cancer combined. This training program aims to provide a rigorous training, emphasizing cross- disciplinary collaboration, in the science of heart muscle health and disease for a diverse group of post- doctoral scholars whose goal is a career of investigation in science or medicine.

PI_NAMEs: ASHLEY, EUAN A;BERNSTEIN, DANIEL  (contact);QUERTERMOUS, THOMAS

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Biology;Myocardial;Training

PROJECT_TITLE: Training in Myocardial Biology at Stanford

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Data Science;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: VETERINARY SCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative (Relevance of this Research to Public Health)  To address the huge challenge to capture and integrate heterogeneous vaccine knowledge in an efficient manner, this project will develop VIOLIN 2.0, a new generation comprehensive vaccine knowledgebase that will cover a wide range of knowledge covering the full vaccine life cycle. We will develop advanced informatics technologies, including literature mining and machine learning tools, web interfaces, databases, and knowledge graphs to build the knowledgebase. Our research will lead to ontology-based standardization and integration of vaccine information, and support deep mechanism analysis and rational vaccine design.

PI_NAMEs: HE, YONGQUN  (contact);HUR, JUNGUK ;TAO, CUI

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Adjuvant;Adverse event;Antigens;Applications Grants;Area;Basic Science;Bioinformatics;Cessation of life;Clinical;Clinical Trials;Collaborations;Communicable Diseases;Communities;Community Developments;community engagement;Community Outreach;Consensus;COVID-19;COVID-19 pandemic;Data;data access;data integration;Databases;Detection;Development;Dimensions;disability;Disease;Educational workshop;Ensure;Epidemiology;Evaluation;Event;experience;Face;FAIR principles;fighting;Funding;gene expression database;Generations;Grant;hackathon;Harvest;HIV;Immune;Immune response;Immunologic Factors;improved;Informatics;informatics tool;Information Retrieval;innovation;insight;interoperability;invention;Knowledge;Knowledge Discovery;Knowledge Extraction;knowledge graph;knowledge integration;knowledgebase;Licensing;Life Cycle Stages;Link;Literature;Machine Learning;machine learning method;Malaria;Manuals;meetings;method development;Methods;Modern Medicine;Molecular;Monitor;National Institute of Allergy and Infectious Disease;Natural Language Processing;Ontology;outreach;pathogen;Pattern;predictive signature;programs;Public Health;Reproducibility;Research;research and development;Resources;response;Safety;Semantics;Source;Standardization;statistical and machine learning;System;Systems Analysis;Technology;text searching;tool;Tuberculosis;United States National Institutes of Health;Vaccination;Vaccine Adjuvant;vaccine adverse event;Vaccine Antigen;Vaccine Design;vaccine development;vaccine formulation;vaccine safety;Vaccines;vector;Visualization;web interface;web site;Work

PROJECT_TITLE: VIOLIN 2.0: Vaccine Information and Ontology LInked kNowledgebase

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative Individuals share segments of their DNA identical by descent due to inheritance of the DNA from a shared ancestor such as a great-grandparent. These identity by descent (IBD) segments can be detected using genotype data, and they can then be used to improve our understanding of human biology and relationships between individuals and populations. We propose to develop three new IBD-based analyses that will enable improved understanding of the role of genetics in human health.

PI_NAMEs: BROWNING, BRIAN LEE (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: autosome;Base Pairing;Biology;Catalogs;Chromosomes;Data;detection method;Disease susceptibility;Distant;DNA;Environmental Exposure;Female;Frequencies;frontier;Gene Conversion;Generations;Genetic;genetic analysis;Genetic Crossing Over;Genetic Recombination;Genome;Genomic Segment;Genotype;Geographic Locations;Goals;grandparent;Health;Historical Demography;Human;Human Biology;identity by descent;improved;Individual;Inherited;Linkage Disequilibrium;male;Maps;Methodology;Methods;migration;Mutation;Natural Selections;offspring;Other Genetics;pathogen;Population;Population Heterogeneity;population migration;Population Sizes;Probability;prototype;Pseudoautosomal Region;Recording of previous events;reproductive success;Role;Sampling;sex;Shapes;Specificity;Surveys;Susceptibility Gene;Time;tool;Variant;Work;X Chromosome

PROJECT_TITLE: Identity by descent in population data

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Genetics;Infertility;Neurosciences;Nutrition;Rare Diseases

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE One in 600 males has an extra X chromosome, known as Klinefelter syndrome. The additional genetic material results in systemic manifestations including abnormal metabolism. This translational study targets one of those metabolic pathways with the goal of improving systemic manifestations in males with Klinefelter syndrome.

PI_NAMEs: DAVIS, SHANLEE  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Adipose tissue;Adolescent and Young Adult;Adult;Affect;Age;Agonist;Androgens;Aneuploidy;Area;Binding;Biopsy;Body mass index;cardiometabolism;Cardiovascular Diseases;Chronic;Clinical;clinical phenotype;clinical translation;cohort;comparison control;Complex;Data;Defect;Development;differential expression;Disease;Dyslipidemias;early childhood;Energy Metabolism;epidemiology study;Exercise;exercise intolerance;experience;Failure;Fasting;Fatigue;Fatty acid glycerol esters;fatty acid metabolism;Fatty Acids;Fenofibrate;Fibrates;Foundations;Functional disorder;Functional impairment;functional restoration;Future;Gene Expression;Genes;Genetic Diseases;Genetic Materials;Genetic Transcription;Goals;Health;High Density Lipoprotein Cholesterol;High Prevalence;Hyperplasia;Hypertriglyceridemia;Hypertrophy;Hypogonadism;Impairment;improved;improved outcome;Inborn Errors of Metabolism;Indirect Calorimetry;Individual;Infertility;Inflammation;Insulin Resistance;Intervention;Intervention Studies;Investigation;Klinefelter's Syndrome;Life;Ligands;Lipids;male;Measures;men;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;metabolome;Mission;Mitochondria;Molecular;Morbidity - disease rate;mortality;Muscle Mitochondria;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Oral;Outcome;oxidation;Oxidative Phosphorylation;Oxidative Stress;Participant;Pathology;Pathway interactions;Patient Self-Report;Patient-Focused Outcomes;Pharmaceutical Preparations;Phenotype;Physiology;Plasma;PPAR alpha;Protocols documentation;Quality of life;Regulator Genes;Rest;Role;Secondary to;sex chromosome aneuploidy;Skeletal Muscle;System;targeted treatment;Testing;Testosterone;theories;Therapeutic Intervention;Tissue-Specific Gene Expression;Tissues;transcription factor;transcriptome;transcriptome sequencing;translational study;Up-Regulation;uptake;Venous blood sampling;Whole Blood;Work;X Chromosome;Youth

PROJECT_TITLE: Interrogating Fatty Acid Metabolism Impairment andClinical Correlates in Males with Klinefelter Syndrome

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: Narrative The long-term goal of this project is to define and identify circuit-specific cell types–cellular scale connectome– that are selectively vulnerable to loss of cell bodies or axonal connections or change of transcriptomic signatures of individual neurons during the progression of healthy aging and Alzheimer's disease (AD). The data from this project will provide novel insights on the types of neurons vulnerable to degeneration and/or alterations of molecular/signaling signature networks in a spatial and temporal fashion and the correlation with neuropathology and cognitive impairment. This approach is a major step toward establishing multiscale models that will help to fill the gap between the effects of genetic variants (e.g., APP, AOPE or TREM2) on brain topology with molecular networks in aging and AD.

PI_NAMEs: BEHRENS, M MARGARITA;LEE, KUO-FEN  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Address;Adrenergic Agents;Affect;Age;age effect;Aging;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Anatomy;Animals;Area;Atlases;Axon;Behavioral;Biochemical;Brain;BRAIN initiative;Brain region;Cell Count;Cell Nucleus;Cell Separation;cell type;Cells;Censuses;Cerebellum;Cognition;connectome;Coupling;Data;Data Set;Deterioration;Disease;Disease Progression;Down-Regulation;Electrophysiology (science);entorhinal cortex;epigenetic profiling;epigenomics;Female;Gene Proteins;Genetic Diseases;genetic variant;Goals;healthy aging;Hippocampus;Human;Impaired cognition;Individual;insight;Joints;Knock-in;Knowledge;Label;Late Onset Alzheimer Disease;Learning;Link;Location;locus ceruleus structure;male;Maps;Memory;Molecular;Morphology;multi-scale modeling;multiple omics;Mus;Mutation;neural;Neurofibrillary Tangles;Neurons;neuropathology;novel;Nuclear Envelope;old mice;Output;Physiological;Prefrontal Cortex;promoter;Property;Recombinant adeno-associated virus (rAAV);Resolution;response;screening;Senile Plaques;Signal Transduction;single nucleus RNA-sequencing;Source;Staging;System;Testing;transcriptome;transcriptomics;TREM2 gene

PROJECT_TITLE: Circuit-specific cell types in aging and Alzheimer's disease


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Genetics;Infectious Diseases;Malaria;Neurosciences;Rare Diseases;Vector-Borne Diseases

ORG_CITY: Nashville

ORG_DEPT: BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE Female mosquitoes find their blood-meal hosts using highly specialized chemosensory appendages that are responsive to host-specific chemical cues, and mosquito behavior directly impacts disease transmission worldwide. The current proposal is designed to discover the function of an uncharacterized family of olfactory receptor genes that are likely to account for a critical portion of host odor recognition in Anopheline mosquitoes and are responsible for transmission of malaria and other diseases. Improving our understanding of mosquito chemosensory biology could ultimately provide novel ways to interfere with blood feeding and other mosquito- host interactions, potentially disrupting disease-transmission cycles.

PI_NAMEs: ZWIEBEL, LAURENCE J (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Adult;adult nutrition;Afferent Neurons;Aldehydes;Amines;Ammonia;Anopheles Genus;appendage;Arboviruses;base;Behavior;Behavioral;Behavioral Assay;Biological Assay;Biology;Blood;Brain;Carboxylic Acids;Chemicals;Chemoreceptors;Complex;CRISPR/Cas technology;Cues;Culicidae;Data;Dengue;design;Disease;disease transmission;Electrodes;Electrophysiology (science);Environment;Etiology;Family;Family member;feeding;Female;Filariasis;Future;Gene Targeting;Hand;Health;Human;Human Bites;Imines;improved;In Situ Hybridization;in vivo;Individual;Intervention;Kairomones;Knock-in;Lactic acid;Larva;loss of function;Malaria;malaria transmission;Maps;Maxilla;Mediating;Molecular;Mosquito-borne infectious disease;mutant;neurogenetics;Neurons;novel;Odors;olfactory receptor;Oocytes;Partner in relationship;Peripheral;Phenotype;Pheromone;Phylogenetic Analysis;Physiological;Play;Population Sizes;preference;programs;Public Health;receptor;Receptor Gene;Reporter Genes;Research;response;Role;Semiochemicals;Sensory;sensory mechanism;Sensory Process;Sensory Receptors;Signal Transduction;single nucleus RNA-sequencing;Skin;Smell Perception;Stimulus;System;Taste Perception;Tissues;transcriptome;Transgenic Organisms;transmission process;Variant;vector;vector control;vector mosquito;Vectorial capacity;Volatilization;voltage clamp;Xenopus laevis;ZIKA

PROJECT_TITLE: Characterization of Ionotropic Receptors in Mating and Blood Feeding in Anopheles mosquitoes

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Mobile health (mHealth) weight management interventions show significant promise as a scalable public health tool to drive population-level improvements in overweight/obesity. However, it is unclear whether mHealth interventions produce equitable outcomes across sociocultural contexts and for racial/ethnic minority populations who experience disproportionate social disadvantage. To address this gap, the proposed project will involve a systematic review and meta-analysis of the availability and efficacy mHealth weight management interventions for racial/ethnic minorities, secondary analyses of the moderating effect of social disadvantage on mHealth weight management intervention success, and qualitative interviews of racial/ethnic minority participants to understand the perceived barriers and facilitators to mHealth weight management.

PI_NAMEs: BATTALIO, SAMUEL LOUIS (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Address;Adult;Behavior;behavior change;Behavioral;Body Weight decreased;Calories;cardiometabolism;Complement;cost;Crime;Data;Data Set;design;Devices;Diet;Disadvantaged;Equity;ethnic discrimination;ethnic disparity;ethnic minority;ethnic minority population;Evaluation;examination questions;experience;Fatty acid glycerol esters;Fellowship;Food Access;Foundations;Goals;Health behavior;health equity;healthy weight;Impairment;improved;Individual;Intervention;Interview;Investigation;Lead;Learning;lifestyle intervention;Literature;Location;Meta-Analysis;Methods;mHealth;mhealth interventions;Minority;Minority Groups;Modeling;Morbidity - disease rate;mortality;Neighborhoods;Obesity;obesity treatment;Outcome;Overweight;Participant;Patients;Perception;Persons;Population;post intervention;Prevalence;programs;Public Health;Race;racial discrimination;racial disparity;racial minority;racial minority population;remote delivery;Research;Research Methodology;Risk Factors;Role;scale up;secondary analysis;social culture;social disparities;Social Environment;social health determinants;social influence;success;systematic review;tool;Training;treatment effect;Treatment Efficacy;trend;Weight;weight loss intervention;Weight maintenance regimen;Work

PROJECT_TITLE: A Mixed-Methods Evaluation of mHealth Weight Management for Racial/Ethnic Minorities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: WORCESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative In response to virus infections, the human immune system produces interferons, a family of proteins that prevent virus replication. We have found that ADAM9, a protein expressed on the surface of human and mouse cells, is required to produce interferons after infection with a virus that causes encephalitis (inflammation in the brain) and myocarditis (inflammation in the heart). In this grant, we will determine how ADAM9 functions during virus infection to support interferon production; this understanding may lead to new ways to treat and prevent viral illnesses including coronavirus infection.

PI_NAMEs: GACK, MICHAELA ULRIKE;KURT-JONES, EVELYN A. (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 2019-nCoV;Adaptor Signaling Protein;Adult;Affect;Animal Model;Anti-viral Response;Binding;Biochemical;Biological;Biological Models;Brain;Cardiac;Cell Nucleus;Cell surface;cell type;Cells;Characteristics;Chemosensitization;Complex;Coronavirus;Coronavirus Infections;Coxsackie Viruses;Cytoplasmic Tail;Cytosol;cytosolic receptor;Data;detection platform;Disintegrins;Encephalitis;Encephalomyocarditis virus;experimental study;Family;Family Picornaviridae;Filament;Genes;Genetic Transcription;Grant;Heart;helicase;Human;IFIH1;Immune;Immune system;Immunologic Receptors;Impairment;in vivo;Infection;Inflammation;Inflammatory;Influenza A virus;Innate Immune Response;innate immune sensing;Integration Host Factors;Interferon Activation;Interferon Type I;Interferon-beta;Interferons;IRF3 gene;knock-down;Knock-out;Knockout Mice;Knowledge;Lead;Lentivirus Vector;Link;Mass Spectrum Analysis;Measures;Mediating;member;Metalloproteases;Mitochondria;Mitochondrial Proteins;Molecular;Morbidity - disease rate;mortality;Mus;mutant;Myocarditis;Natural Immunity;novel;Nucleic Acids;Pathogenesis;Pathway interactions;Picornaviridae Infections;Post-Translational Protein Processing;prevent;Process;Production;protein activation;Protein Dephosphorylation;Protein Family;protein protein interaction;Proteins;receptor;reconstitution;recruit;Regulation;Research Personnel;response;RNA;RNA Binding;RNA Virus Infections;RNA Viruses;Role;Sendai virus;sensor;Series;SH3 Domains;Signal Pathway;Signal Transduction;single-cell RNA sequencing;STAT1 gene;Surface;TBK1 gene;Tissues;transcriptome sequencing;Tretinoin;Ubiquitination;Vesicular stomatitis Indiana virus;Viral;Viral Encephalitis;Viral Genome;viral myocarditis;Viral Pathogenesis;viral RNA;Virus;Virus Diseases;Virus Replication;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Role of ADAM9 in viral RNA sensing and antiviral innate immunity

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Despite years of effort, ethnic disparities in access to live donor kidney transplants – the optimal treatment option for individuals living with chronic and end-stage kidney disease, persist and Black patients continue to have the lowest rates of living donor transplants. This application proposes to explore the instrumental, relational and affective communication occurring between Black and Caucasian patients and their transplant providers during transplant evaluation consultations and assess relationships between these communicative elements and patient and provider factors, patient-reported outcomes and living donor transplant outcomes - living donor referrals, evaluations, and transplants. We will use these findings to inform the development of a communication skills training for transplant providers and test the impact of the training on providers’ communication about live donor kidney transplants with Black and Caucasian patients and living donor transplant outcomes.

PI_NAMEs: GARDINER, HEATHER MARIE (contact);WENG, FRANCIS L

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: acceptability and feasibility;access disparities;Affective;American;Area;Asian;Asian population;Attitude;Behavior;black patient;Black Populations;Black race;care outcomes;Caring;Caucasians;Chronic;Chronic Kidney Failure;Client satisfaction;Communication;communication behavior;Communities;Consultations;cost;Data;Decision Making;design;Development;Dialysis procedure;digital;Donor person;Elements;End stage renal failure;Equity;ethnic disparity;ethnic minority;Ethnic Origin;Evaluation;Exhibits;feasibility testing;Frequencies;Goals;Health;health disparity;health literacy;Hispanic;Hispanic Populations;improved;Individual;Inequity;innovation;Intervention;Kidney Failure;Kidney Transplantation;Knowledge;Life;Living Donors;Medical;Medical center;Medicine;Mental Health;Methodology;Methods;Minority;Modality;Modeling;Morbidity - disease rate;mortality;Nature;non-verbal;optimal treatments;Organ Donations;Outcome;parity;participant enrollment;Patient Compliance;Patient Outcomes Assessments;patient stratification;patient-clinician communication;Patients;physical conditioning;Physicians;Predictive Factor;Process;Prospective Studies;Provider;provider communication;provider factors;Quality of life;Readiness;Reporting;Research;Saints;Sampling;satisfaction;shared decision making;Site;skills;skills training;Surveys;Testing;therapy design;Training;Transcript;transplant centers;Transplantation;Treatment Protocols;University Hospitals;Variant;Waiting Lists

PROJECT_TITLE: Increasing Equity in Live Donor Kidney Transplant through Effective Patient-Provider Communication (EPPCom)

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Serious Mental Illness

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE This project aims to utilize personalized artificial intelligence techniques and objective data (collected from smartphones and wearable devices) to create individualized digital biomarkers of rapid changes in major depressive disorder symptoms. This is important because, if we were to uncover personalized patterns between objectively measured physiology and behavioral changes and understand their resulting impact on rapid fluctuations in major depressive disorder symptoms, we would be able to define new, person-specific maintenance patterns that underlie the wide-ranging heterogeneity that is currently seen in patients suffering from major depressive disorder. Moreover, these advancements will provide a crucial step forward towards developing personalized, scalable, technology-based interventions that will be able to be delivered immediately (and, ideally, before rapid symptom changes) among those persons with major depressive disorder.

PI_NAMEs: JACOBSON, NICHOLAS CHARLES (contact)

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TERMS: actigraphy;Address;Adult;Affect;analog;Arousal;Artificial Intelligence;Behavior;Behavior Therapy;Behavioral;Big Data;Biological Markers;biomarker driven;burden of illness;Cellular Phone;Cessation of life;cohort;Collection;Data;deep learning;deep learning model;Depressed mood;depressive symptoms;Deterioration;Digital biomarker;disability;Ecological momentary assessment;Enrollment;Exposure to;Fostering;heart rate variability;Heterogeneity;Hour;Individual;information gathering;innovation;Life;Light;Location;Maintenance;Major Depressive Disorder;Measures;meetings;microphone;Modeling;Moods;Motor;multimodality;National Institute of Mental Health;Negative Valence;novel;Participant;Patient Self-Report;Patients;Pattern;Performance;personalized biomarkers;personalized medicine;Persons;phenomenological models;Photoplethysmography;Physiological;Physiology;Population;Positive Valence;premature;prevent;Process;Research;Research Domain Criteria;Sampling;sensor;Signal Transduction;Sleep;Sleep disturbances;smartphone based device;social;social contact;Subgroup;Surveys;Symptoms;System;Techniques;Technology;technology intervention;Testing;Time;treatment planning;treatment response;tv watching;Variant;wearable device;wearable sensor technology;Wrist;wrist worn device

PROJECT_TITLE: Personalized Deep Learning Models of Rapid Changes in Major Depressive Disorder Symptoms using Passive Sensor Data from Smartphones and Wearable Devices

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Cancer incidence is significantly increasing in Ghana, a country that has a nidus of cancer researchers, but requires a larger cadre of researchers trained across multiple cancer disciplines to address the growing cancer problem. We propose a 5-year cancer research training program for Ghana, “Ghana IntegRative Approach to Cancer ResEarch Training: The GRACE Program,” that builds on existing research collaborations between the Moffitt Cancer Center and the Ghana health systems (i.e. University of Ghana Medical School, School of Public Health, Korle-Bu Teaching Hospital, and the College of Physicians and Surgeons), and leverages existing educational materials that will provide short-, medium, and long-term cancer research training to ~150 trainees, that can be sustained beyond the funding period.

PI_NAMEs: GIULIANO, ANNA R.;GWEDE, CLEMENT K.;YAMOAH, KOSJ  (contact);YARNEY, JOEL

PROGRAM_OFFICER_NAME: SIVARAM, SUDHA

PROJECT_TERMS: Acceleration;Address;Affect;Africa South of the Sahara;African American population;anti-cancer research;Applied Research;Breast;Cancer Center;Cancer Control;cancer site;Cervical;clinical care;Collaborations;college;Community Health;Country;Discipline;Educational workshop;experience;Faculty;Funding;Generations;Ghana;global health;Goals;Grant;Growth;Head and neck structure;Health;Incidence;Institution;institutional capacity;interest;lectures;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Education;medical schools;Morocco;mortality;multidisciplinary;Nursing Schools;Oncology;Physicians;Policy Maker;programs;Public Health;Public Health Schools;recruit;Research;Research Personnel;Research Training;Science;Scientist;Structure;Surgeon;System;Talents;Teaching Hospitals;Training;Training Programs;Universities;Work

PROJECT_TITLE: Ghana IntegRative Approach to Cancer ResEarch Training: The Grace Program


NIH_SPENDING_CATS: Immunotherapy;Physical Injury - Accidents and Adverse Effects

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The behavior of the immune system governs the clinical course of people that are severely injured. We propose that severe injury disrupts immune system homeostasis making people more susceptible to life- threatening infections and complications caused by trauma and infections. This project will study how an immune cell type called regulatory T cells react to traumatic injuries and how they function to control immune responses to trauma and infections.

PI_NAMEs: LEDERER, JAMES A. (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Acute;Address;Affect;Antigens;antimicrobial;Applied Research;Bacteria;Bacterial Pneumonia;Basic Science;Behavior;Biology;Burn Trauma;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell type;Cells;Chronic;Clinical;Complex;Critical Illness;cytokine;Data;Disease;Equilibrium;experimental study;Goals;Health;Homeostasis;Immune;immune function;Immune response;Immune system;Immunity;Immunology;immunoreaction;immunoregulation;Immunotherapy;improved;Infection;Inflammation;Inflammatory;Injury;insight;interest;Knowledge;Life;Modeling;Molecular;Molecular Profiling;Mus;Nature;novel;Opportunistic Infections;Organ;Outcome;Outcomes Research;Patients;Pattern;Peripheral;Persons;Phenotype;post-trauma;Predisposition;Process;Publishing;Reaction;Regulatory T-Lymphocyte;Reporting;Research;response;restoration;Series;severe injury;Specificity;Stimulus;Systemic Inflammatory Response Syndrome;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;tissue injury;Tissues;Trauma;Traumatic injury

PROJECT_TITLE: Adaptive Immune Regulation of Traumatic Injury

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Even when HIV replication is suppressed with ART, people infected with HIV present with a chronic inflammatory state that is thought to contribute to the development of neurologic and psychiatric co-morbid conditions. Here we have identified the sphingomyelin hydrolase neutral sphingomyelinase2 (nSMase2) generated ceramide as a critical regulator of the innate immune response to ART suppressed HIV infection.

PI_NAMEs: DAWSON, VALINA L.;HAUGHEY, NORMAN J (contact);XU, JINCHONG

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: antiretroviral therapy;Apoptosis;Binding;Biological Models;Brain;brain tissue;cell injury;Cell Survival;Ceramides;Cerebrospinal Fluid;Chronic;chronic infection;Complement;cytokine;Cytoprotection;Developed Countries;Development;Event;Exposure to;Extracellular Matrix;Family;Frequencies;Functional disorder;Goals;HIV;HIV Infections;humanized mouse;Hydrolase;IL18 gene;Immune response;Immunologic Memory;Impaired cognition;Inflammasome;Inflammation;Inflammatory;Injury;innate immune function;Innate Immune Response;Innate Immune System;Leucine-Rich Repeat;Lipids;marenostrin;Metabolism;Microglia;Molecular;Motion;mouse model;Natural Immunity;Nerve Degeneration;Nervous System Trauma;neural;neural network;neuroAIDS;Neurologic;Neurons;Nucleotides;pathogen;Pattern;Pattern recognition receptor;Peptide Hydrolases;Persons;Phenotype;Play;Polysaccharides;Production;protein aggregation;Protein Fragment;Proteins;Proteoglycan;psychiatric comorbidity;receptor;response;Role;Shapes;Signal Transduction;Sphingomyelinase;Sphingomyelins;Stimulus;Structure;Synapses;Terminal Disease;Testing;tissue repair;Tissues;Toll-like receptors;Virus Diseases

PROJECT_TITLE: Innate immune memory promotes neural damage in the ART suppressed HIV infected brain


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Allergies and immune system diseases are becoming increasingly common, especially in children. Treatment options are limited so research to identify both the roots of these disorders and possible treatments is critical. This Training Program seeks to recruit talented young MD pediatricians and PhD scientists committed to translational research and to prepare them for careers as productive investigators in the area of pediatric immunology.

PI_NAMEs: CHOU, JANET ;NIGROVIC, PETER A;OETTGEN, HANS C (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Allergic Disease;Immune System Diseases;Molecular

PROJECT_TITLE: Molecular Basis of Allergic and Immunologic Disease

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Lung;Lymphatic Research;Pediatric;Prevention;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE It is increasingly appreciated that aberrations in lymphatic structure and function participate in the pathogenesis of a variety of pulmonary diseases including the abnormal respiratory mechanics of children with common congenital heart disease (CHD) associated with increased pulmonary blood flow (PBF). In this proposal we will comprehensively elucidate the role of the altered lymphatic mechanical forces and subsequent HIF-1 stabilization in the pathobiology of lymphatic dysfunction in this setting, and the potential therapeutic targets that may restore lymphatic function. The data from these integrated in vitro and in vivo studies may easily translate into novel treatment and prevention strategies for lymphatic abnormalities in the setting of CHD and other disease states, including pneumonectomy and other vascular abnormalities that result in increased PBF.

PI_NAMEs: DATAR, SANJEEV A. (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Adult;Animal Model;Animals;antagonist;Antioxidants;Architecture;Biological Availability;Blood flow;bosentan;Cannulations;Cardiac;Catheters;Cell Culture Techniques;cell growth;Cell Proliferation;Cell Separation;Characteristics;Child;Chronic;Chylothorax;clinically relevant;congenital heart abnormality;data integration;Devices;Disease;endothelial dysfunction;Endothelin-1;experimental study;Exposure to;genetic manipulation;Genetic Transcription;heart defect;hemodynamics;Hypoxia Inducible Factor;Immunologics;improved;In Vitro;in vivo;in vivo evaluation;Lung;Lung Diseases;lymph flow;Lymphatic;Lymphatic clearance;lymphatic development;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic Endothelium;Lymphatic function;lymphatic malformations;Magnetic Resonance Imaging;mechanical force;Mediating;Membrane Potentials;Metabolic;metabolic abnormality assessment;Mitochondria;mitochondrial membrane;mitoquinone;Molecular;Morbidity - disease rate;mortality;Nitric Oxide;novel;Pathogenesis;Patients;pharmacologic;Phenotype;Physiological;Piezo 1 ion channel;Play;Pneumonectomy;Prevention strategy;programs;Proliferating;Pulmonary function tests;Reactive Oxygen Species;receptor;repaired;Respiration Disorders;Respiratory Mechanics;Risk Factors;Role;shear stress;Shunt Device;Signal Pathway;Signal Transduction;Source;SRC gene;Structure;Testing;therapeutic target;Thoracic Duct;Time;Translating;treatment strategy;vascular abnormality

PROJECT_TITLE: Altered Lymphatic Function and Development in Congenital Heart Disease

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: RELEVANCE TO PUBLIC HEALTH Drug addiction, a chronic disease driven by neurobiological mechanisms and associated with predisposing behaviors including novelty-seeking and risk-taking, represents a tremendous legal, social, and public health burden both in the US and worldwide. There are limited treatment options and no pharmaceuticals for cocaine use disorder. By using and extending advanced mouse genetics resources and analysis techniques, we will discover biological mechanisms of addiction and related behaviors, which may ultimately result in novel predictive and therapeutic avenues for disorders of addiction.

PI_NAMEs: CHESLER, ELISSA J (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: addiction;Address;Animals;Area;Back;Behavior;Behavioral;Behavioral Genetics;behavioral genomics;behavioral response;Biological;biological systems;Brain region;Cessation of life;Chronic Disease;Cocaine;Cocaine Dependence;cocaine related behaviors;cocaine self-administration;Cocaine use disorder;Collection;Complex;Computational Science;Computing Methodologies;Corpus striatum structure;data integration;data resource;Data Set;Development;Dimensions;Disease;Disparate;Drug Addiction;Drug Exposure;Drug usage;Economic Burden;Epidemic;experience;Extinction;Fentanyl;Gene Expression;Gene Expression Profiling;Gene Modified;Gene Targeting;Genes;Genetic;genetic analysis;Genetic Determinism;Genetic Polymorphism;genetic resource;Genetic Transcription;genetic variant;Genetic Variation;genomic locus;Genomics;Goals;Heritability;Human;Human Genetics;Individual;innovation;insight;Intervention;Intravenous;Joints;Laboratories;Legal;Maps;Measurement;Measures;member;Methodology;Methods;Modification;Molecular;mouse genetics;mouse model;multidimensional data;multimodal data;Mus;neurobehavioral;neurobiological mechanism;novel;Pattern;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Police;Population;Predisposition;Prefrontal Cortex;Process;Public Health;Quantitative Trait Loci;recruit;Research;Resource Informatics;Resources;Risk Assessment;Risk Taking;RNA Sequence Analysis;Rodent;Sampling;Scientist;Self Administration;Services;sex;social;Statistical Methods;Street Drugs;Substance Use Disorder;success;synergism;System;Systems Development;technique development;Techniques;Testing;The Jackson Laboratory;Therapeutic;Tissues;tool;trait;transcriptome;transcriptome sequencing;Universities;Validation;validation studies;Variant;Work

PROJECT_TITLE: Discovery of Addiction-Related Genes with Advanced Mouse Resources

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

PHR: The sympathetic nervous system is a key regulator of whole body physiology. We recently showed that satellite glial cells, an often ignored cell type in the nervous system, are a key regulator of sympathetic neuron function. In this proposal, we will address how sympathetic neurons and satellite glial cells communicate with one another to influence the co-development of these two cell types. A better understanding of neuron-satellite glia interactions is critical for a fundamental knowledge of the normal sympathetic nervous system, and will guide new treatments for devastating disorders linked to sympathetic dysfunction such as chronic heart failure and hypertension.

PI_NAMEs: KURUVILLA, REJJI  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Ablation;Address;Adhesives;Axon;BAX gene;Biochemical;Biochemistry;Brain;Candidate Disease Gene;Cell Communication;Cell Physiology;cell type;Cell-Cell Adhesion;Cellular biology;Cellular Morphology;chronic pain;Coculture Techniques;Communication;conditional knockout;Congestive Heart Failure;Cues;Defect;defined contribution;Dendrites;Dependence;Development;Diabetes Mellitus;Disease;EGF gene;Environment;fighting;Functional disorder;Ganglia;Genetic;glial cell development;Glial Cell Proliferation;Goals;Growth;Heart failure;Homeostasis;Human;Hypertension;Image;In Vitro;in vivo;Individual;Insulin Resistance;Integral Membrane Protein;Knockout Mice;Knowledge;Link;Mediating;Membrane Proteins;Modeling;Molecular;Morphogenesis;Morphology;mouse genetics;mouse model;Mus;Muscle satellite cell;Mutant Strains Mice;Nerve Regeneration;nerve supply;Nervous System;neural circuit;Neuroglia;neuron development;neuron loss;neuronal cell body;neuronal survival;Neurons;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 1;NGFR Protein;notch protein;Organ;Output;Parkinson Disease;Pathway interactions;Peripheral;Peripheral Nervous System Diseases;Physiology;prevent;Process;receptor;receptor binding;Reporting;Research;response;Role;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Structure;Sympathetic Ganglia;Sympathetic Nervous System;Synapses;Synaptic Transmission;System;Testing;Tissues;Work

PROJECT_TITLE: Neuron-satellite glia interactions in the sympathetic nervous system

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Clinical Research;Diabetes;Infectious Diseases;Wound Healing and Care

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Diabetic foot ulcers (DFU) are a common reason for hospitalization of diabetic patients and frequently it results in amputation of lower limbs and loss of lives. Recurrence is frequent. The proposed project is based on the study of DFU patients and aims to directly impact improvement of wound care such that wound closure includes restoration of skin function and is therefore less susceptible to recurrence.

PI_NAMEs: GURTNER, GEOFFREY C;SEN, CHANDAN K (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Address;Amputation;Animal Model;Animals;Area;Award;Bacteria;Biological;Caring;chronic wound;Clinical;Clinical Research;Colony-Forming Units Assay;Complication;Complications of Diabetes Mellitus;Data;Data Collection;Defect;diabetic;Diabetic Foot Ulcer;diabetic patient;Drainage procedure;Epithelial Attachment;Epithelium;Foot Ulcer;Foundations;Funding;Gene Silencing;Hospitalization;improved;Incidence;Indiana;Infection;Infectious Skin Diseases;interest;Lead;Leg;Lower Extremity;Measures;Metabolic;Methodology;Microbial Biofilms;MicroRNAs;Molecular;mortality risk;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;Patients;Persons;Pilot Projects;posttranscriptional;pre-clinical;Predisposition;premature;primary endpoint;re-epithelialization;recidivism;Recording of previous events;Recurrence;repair function;Reporting;Research;Research Design;Rest;restoration;Risk;Series;Site;Skin;skin barrier;Skin repair;standard of care;Techniques;Testing;Time;Tissues;Training;Ulcer;Universities;Visit;Water;Work;wound;wound biofilm;wound care;wound closure;wound healing;Wound Infection

PROJECT_TITLE: Diabetic Foot Ulcer Biofilm Infection and Recurrence


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_CITY: BLACKSBURG

ORG_DEPT: NEUROSCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Deficits in reward-related behavior are key features of depression, drug abuse, and obesity that are believed to stem from alterations in dopamine release in the striatum. Striatal dopamine systems are designed to integrate signals from the periphery to modulate reward-related behaviors, however the timescales over which these signals act, and their specific contributions to reward-related behaviors are unknown. Here, we propose to address this gap in our knowledge and uncover a new mechanism through which dopamine systems mediate adaptive behaviors that are disrupted in multiple diseases.

PI_NAMEs: HOWE, WILLIAM MATTHEW (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Adaptive Behaviors;Address;Anatomy;Appetitive Behavior;Behavior;Behavioral;Big Data;Brain;Calories;Carbohydrates;Cells;Code;Collaborations;computational neuroscience;Consumption;Corpus striatum structure;Data;Data Analyses;design;Disease;Dissociation;Dopamine;dopamine system;Dorsal;Drug abuse;Eating;Event;experimental study;Fatty acid glycerol esters;Fiber;Food;Foundations;Functional Magnetic Resonance Imaging;Future;genetic manipulation;Goals;gut-brain axis;Human;human subject;Immunohistochemistry;Individual;Infusion procedures;Knowledge;Label;Lead;Learning;Link;Macronutrients Nutrition;Measures;Mediating;Mental Depression;Midbrain structure;Modeling;Modernization;Monitor;Motivation;Mus;Natural Selections;neural;Neurobiology;Neurons;Neurosciences;novel;Nucleus Accumbens;Nutrient;Obesity;Optics;Oral cavity;Pathway interactions;Peripheral;Phenotype;Photometry;Play;Population;Proteins;Psychological reinforcement;recruit;reinforced behavior;Research;Research Support;response;reward dysfunction;Rewards;Role;Self Stimulation;Shapes;Signal Transduction;Statistical Models;stem;Stimulus;Substantia nigra structure;Support System;System;Techniques;Technology;Testing;theories;Time;Training;translational potential;Ventral Tegmental Area;Viral Vector;Work

PROJECT_TITLE: A gut-brain interaction controlling reward learning

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Narrative: Obesity is one of the most prevalent medical problems facing children and adolescents today, particularly among African American adolescents where the rate is alarmingly high. This study will test the effectiveness of FIT Families, a multicomponent family-based behavioral intervention that is culturally tailored to meet the unique needs of African American adolescents with obesity and their caregivers, against a credible attention control condition. This study has considerable public health relevance because it is delivered by Community Health Workers, maximizing the potential for the intervention to be sustained, and may reduce obesity-related health problems for a vulnerable population of adolescents.

PI_NAMEs: CUNNINGHAM, PHILLIPPE BELTON (contact);GHOSH, SAMIRAN

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;Adult;Advisory Committees;African American;African American population;Age;aged;American;Asthma;attentional control;Basic Science;Behavior;Behavior Therapy;Behavioral;behavioral clinical trial;Behavioral trial;bench-to-bedside translation;Body Weight decreased;Cardiovascular Diseases;Cardiovascular system;Caregivers;Child;Clinical Trials;Cognitive;Communication;Community Health Aides;contingency management;cost;Cost Analysis;cost effectiveness;Costs and Benefits;diet and exercise;Diet Monitoring;disparity reduction;Drops;early phase trial;Educational process of instructing;Effectiveness;effectiveness testing;efficacy evaluation;efficacy study;efficacy testing;efficacy trial;Eligibility Determination;Enrollment;ethnic minority;evidence base;executive function;extrinsic motivation;Family;family support;fitness;follow-up;Grant;Health;Health Care Costs;Health Status;high risk;Home;home based service;Hypertension;improved;Incentives;Intervention;intervention cost;Intervention Trial;Interview;intrinsic motivation;Life Style;Malignant Neoplasms;markov model;mathematical model;Measures;Medical;Metabolic;Metabolic syndrome;Methodology;minority children;Modeling;Monitor;motivational enhancement therapy;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Obesity associated disease;obesity risk;obesity treatment;Outcome;Overweight;parental role;Phase;Phase Ia Trial;Phase Ib Trial;phase III trial;Physical activity;Play;Population;primary caregiver;Procedures;Protocols documentation;Public Health;public health relevance;Randomized;randomized trial;randomized, clinical trials;recruit;Research;Research Priority;Risk;Risk Factors;satisfaction;Science;secondary outcome;Sequential Multiple Assignment Randomized Trial;Series;skill acquisition;skills;skills training;Societies;South Carolina;Stroke;Stroke Belt;Symptoms;Testing;Training;Translating;translational research program;United States National Institutes of Health;Vulnerable Populations;Weight;Weight maintenance regimen;Youth

PROJECT_TITLE: Clinical Trial of the Fit Families Multicomponent Obesity Intervetnion for African American Adolescents and Their Caregivers: Next Step from the ORBIT Initiative

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(OA)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Heart muscle is formed by protein filaments that slide past each other, pulled by miniature molecular motors that produce force and pump the blood. In healthy relaxed heart, the motors are switched off in an energy-saving mode, while genetic mutations can damage the motors, causing increased energy usage and heart disease. We will use powerful microscopes to observe the atomic structure of the motors, illuminating how they work normally, malfunction in disease, and are repaired by drugs that restore their function.

PI_NAMEs: PADRON, RAUL  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Accounting;Actins;Address;Animals;biophysical techniques;blood pump;Cardiac;Cardiac Myosins;Cardiomyopathies;Cryoelectron Microscopy;Diastole;Dilated Cardiomyopathy;Disease;DNA Sequence Alteration;drug action;Drug usage;Electron Microscopy;Energy consumption;Equilibrium;Exhibits;Familial Hypertrophic Cardiomyopathy;Filament;Fishes;Goals;Grant;H-Meromyosin;Head;Heart;Heart Diseases;Human;Hypertrophic Cardiomyopathy;Image;improved;Induced Mutation;inherited cardiomyopathy;insight;Knowledge;Measures;Microscope;microscopic imaging;Molecular Conformation;molecular dynamics;Molecular Motors;Motor;Muscle;Muscle function;Muscle relaxation phase;mutant;Mutation;Myocardium;Myopathy;Myosin ATPase;Myosin Type II;Negative Staining;particle;Pathologic;Pharmaceutical Preparations;Property;Proteins;Regulation;Relaxation;repaired;Resolution;Roentgen Rays;Role;Slide;Structure;Tail;Testing;Therapeutic;Thick Filament;Time;Work

PROJECT_TITLE: Structural basis of the super-relaxed state in human cardiac muscle

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Disability Research;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Rehabilitation;Stroke

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Stroke is the leading cause of long-term disability. Most stroke survivors have some degree of spontaneous recovery, but this recovery is unpredictable and in many cases incomplete. The overarching goal of this proposal is to understand mechanisms brain repair after stroke. Enhancing these mechanisms may be key to designing therapies to improve recovery and attenuate disability after stroke. In this grant, we propose to study inhibitory parvalbumin interneurons, a subclass of neurons that are critical “gatekeepers” of brain plasticity. We will manipulate neuronal activity in parvalbumin interneurons to determine if brain repair mechanisms can be enhanced. Furthermore, we will examine the interaction of parvalbumin interneurons and the excitatory pyramidal neurons, to determine how these two classes of neurons interact to affect plasticity and brain repair.

PI_NAMEs: LEE, JIN-MOO  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acceleration;Adolescent;Adult;Affect;Area;Attenuated;Auditory area;barrel cortex;Behavior;Behavioral;Binocular Vision;Bioinformatics;Brain;Brain Injuries;brain repair;Calcium;Cementation;Complex;Corpus striatum structure;critical developmental period;Data;deprivation;designer receptors exclusively activated by designer drugs;Development;developmental plasticity;disability;Distant;ErbB4 gene;Excitatory Synapse;Eye;functional restoration;Future;gamma-Aminobutyric Acid;Gatekeeping;Gene Expression;gene network;Gene Transfer;Genes;Genetic;Goals;Grant;hippocampal pyramidal neuron;Hippocampus;Human;improved;Infarction;inhibitory neuron;Interneurons;Ischemia;ischemic injury;Long term disability;Maps;Mediating;Molecular;monocular deprivation;Mus;Neuregulin 1;neuroimaging;Neuronal Plasticity;Neurons;Ocular Dominance;Ocular dominance columns;Optics;Parvalbumins;Patients;Pattern;Pharmacology;post stroke;Prefrontal Cortex;Prevalence;Process;receptor;Recovery;recruit;repaired;Role;segregation;Sensory;sensory cortex;Sensory Deprivation;Signal Transduction;Somatosensory Cortex;Stroke;stroke recovery;stroke survivor;Surgical sutures;Synapses;targeted treatment;Testing;Therapeutic Intervention;therapy design;Time;Translating;translatome;Vibrissae;Viral Genes;Visual Cortex;visual deprivation

PROJECT_TITLE: Plasticizing the cortex to enhance stroke recovery


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE The suicide death rate among Black male youth is increasing faster than any other racial/ethnic group, yet critical research gaps regarding the influence of racism-related stress exposures alone or combined with other proximal risks on suicidal thoughts and behaviors persist. This career development award will address these gaps by studying (1) whether racism-related stressors, such as discrimination, exacerbate suicide-related behavioral and cognitive processes for Black male youth; and (2) whether capturing these mechanisms in “real-time” can better enhance the early detection of suicide.

PI_NAMEs: ADAMS, LESLIE BERNICE (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: 14 year old;18 year old;Accelerometer;acceptability and feasibility;Accident and Emergency department;Acute;Address;Adolescent;Adult;Affect;Age;aged;Area;Automobile Driving;Behavioral;biological adaptation to stress;black men;Black race;career;Caregivers;Cause of Death;Cellular Phone;cognitive process;cognitive testing;cooking;Data;Data Collection;Death Rate;Detection;Development;digital;digital phenotyping;Discrimination;Distal;Early Diagnosis;Ecological momentary assessment;Enrollment;Environment;Ethnic Population;experience;Feeling;Feeling hopeless;Feeling suicidal;Future;health disparity;health equity promotion;Health Services Research;Holly;Hospitals;innovation;inpatient psychiatric treatment;insight;interest;Interview;Investigation;Joints;K-Series Research Career Programs;Light;Location;longitudinal analysis;longitudinal design;Male Adolescents;Measures;member;Mental Health;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodological Studies;Methodology;mHealth;National Institute of Mental Health;Participant;Pattern;pediatric emergency;Policy Maker;Population;Positioning Attribute;prevent;Prevention Research;Procedures;Process;protocol development;Protocols documentation;Psychiatric Diagnosis;psychological distress;Public Health;public health priorities;Race;racial population;racism;Recontacts;recruit;Research;Research Design;Research Personnel;retention rate;Risk;Risk Assessment;Risk Factors;risk prediction;Role;Sampling;sensor;Shapes;Signal Transduction;skills;Social Environment;social space;sociodemographics;Stress;stressor;Structure;study population;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Surveys;Testing;theories;Time;Training;Translational Research;Variant;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Uncovering proximal antecedents to Black male suicide using real-time approaches

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Genetics;Mental Health;Mental Illness;Pediatric;Prevention;Substance Misuse;Underage Drinking

PHR: PROJECT NARRATIVE Discovering unique, biologically-based pathways to problematic alcohol use (ALC) will help us tailor interventions for this condition. This proposal will examine patterns by which adolescent risk factors for ALC are inherited in families to identify new genetically-based traits; these traits could lead us to discover novel individualized treatment targets for ALC. Testing sex differences in these new genetically-based traits and their relation to ALC will shed light on whether differing treatments are needed for males and females.

PI_NAMEs: WANG, FRANCES L (contact)

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;Age;Aggressive behavior;Alcohol abuse;Alcohol consumption;alcohol content;alcohol risk;alcohol use disorder;Anhedonia;Area;Award;Characteristics;Child;cohort;comorbidity;conduct problem;Consultations;cost;Data;data harmonization;data integration;Data Set;depressive symptoms;deter alcohol use;Development;Dimensions;Distant;Emotions;Environment;Etiology;Family;Female;Frequencies;Fright;Frustration;Functional disorder;gene discovery;Genetic;genetic pedigree;Genetic Risk;Genetic study;Genetic Variation;genome-wide;genomic data;Genotype;Growth;Heritability;Impairment;improved;Impulsivity;Individual;individualized medicine;individualized prevention;Inherited;insight;Intervention;Irritable Mood;Longitudinal Studies;male;Measures;Mental Depression;Mentors;Methods;Michigan;Modeling;negative affect;neural;novel;open data;Outcome;Parents;Pathway interactions;Pattern;Phenotype;population based;precision medicine;Prevention;programs;Prospective cohort;Psychopathology;Quantitative Genetics;Reproducibility;Research;Risk;Risk Factors;sex;Sex Differences;Signal Transduction;skills;Societies;substance use;Substance Use Disorder;Surveys;Symptoms;Targeted Research;Temperament;Testing;Time;Training;trait;Universities;Work

PROJECT_TITLE: The development of genetically-based pathways underlying problematic alcohol use

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: EAST LANSING

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE In mammals, including humans, successful pregnancy requires that the newly formed embryo create its own placenta for the mother to accept and later utilize. At the same time, the embryo must also reserve some cells to become the fetus – a process that is less well understood. Using mouse as a model for mammalian development, our team will apply new methods to discover where, when, and how, the fetus is first established to enable healthy pregnancy.

PI_NAMEs: RALSTON, AMY  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Binding Sites;cell fate specification;Cell Nucleus;Cells;Child Development;Chromatin;Chromatin Remodeling Factor;cofactor;Collaborations;Compensation;Complex;Defect;Development;Embryo;embryo cell;Embryonic Development;embryonic stem cell;Endowment;Ensure;Epiblast;Exhibits;experimental study;Family;Fetus;fetus cell;Gene Expression;gene repression;Genes;Genetic Transcription;genome editing;Genomics;healthy pregnancy;Human;implantation;in vivo;interest;Knock-out;Knowledge;Mammals;member;Methods;Modeling;Molecular;Mothers;mouse model;Mus;novel;NuRD complex;Oocytes;Pattern;Placenta;pluripotency;pluripotency factor;Pregnancy;Process;Publishing;recruit;Repression;Role;Series;Signal Transduction;single cell analysis;SOX15 gene;SOX21 gene;Specific qualifier value;Surface;Testing;Time;Transcription Coactivator;transcription factor;Work

PROJECT_TITLE: Signaling-regulated establishment of pluripotency in vivo

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Clinical Research;Health Services;Social Determinants of Health

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The morbidity, mortality, and costs attributable to critical illness are enormous and rising. This postdoctoral program integrates clinical experience, health services research training, policy analysis, and leadership and career development opportunities for physicians trained in adult or pediatric critical care medicine. These trainees form a cadre of physician leaders capable of improving the efficiency of critical care delivery at the bedside, across populations, and alongside policymakers.

PI_NAMEs: HALPERN, SCOTT D (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Critical Care;Health Policy;Policy Research;Training

PROJECT_TITLE: Training in Critical Care Health Policy Research

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Cardiovascular;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Tyrosine kinase inhibitors (TKIs) are the mainstay therapies for various malignancies; however, several common TKIs are associated with vascular toxicity. In this proposal, we will investigate the underlying mechanisms of TKI-induced vascular toxicity (TKI-VT) by employing iPSC technologies, tissue engineering, multi-omics, CRISPR genome screening, and animal models. The knowledge we gain here will provide novel insights into the pathogenesis of TKI-VT and enable the identification of druggable therapeutics to prevent or treat TKI-VT.

PI_NAMEs: WONG, WING H.;WU, JOSEPH C. (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: 3-Dimensional;Acute Coronary Event;Adhesions;Affect;African American population;Animal Model;Arteries;Asian population;Biological Assay;Blood capillaries;Blood Pressure;Blood Vessels;C57BL/6 Mouse;Cancer cell line;Cancer Patient;Candidate Disease Gene;Cardiac;Cardiovascular system;Caucasians;Cell Density;Cell Physiology;Cell Proliferation;cell type;Cells;Circulation;Citrates;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collagen Type I;Coronary;CRISPR screen;Data;Dissociation;druggable target;Echocardiography;endonuclease;Endothelial Cells;endothelial stem cell;Endothelium;Environment;Enzyme-Linked Immunosorbent Assay;Ethnic Origin;Exclusion;Extracellular Matrix;Force of Gravity;Functional disorder;Gene Targeting;Genome;Grant;Hispanic Populations;Histology;Human;human induced pluripotent stem cells;Hydrogels;Hypertension;induced pluripotent stem cell;induced pluripotent stem cell technology;Inflammation;insight;Journals;K-562;Knowledge;Length;Libraries;Malignant Neoplasms;Mediating;Methodology;Methods;migration;Modeling;Molecular;monocyte;monolayer;mortality;mouse model;multiple omics;Mus;Myocardial Infarction;Myography;Nature;novel;novel therapeutics;Oncology;Oxidative Stress;Paper;Pathogenesis;Pathology;Patients;Pericytes;Peripheral arterial disease;Permeability;Physiological;Plasma;pressure;prevent;Proliferating;Protocols documentation;Publications;Publishing;Qi;racial diversity;recruit;Reporting;Resistance;Role;Safety;screening;self assembly;side effect;Signal Pathway;single-cell RNA sequencing;Stroke;Testing;Therapeutic;thrombogenesis;Thrombosis;Tissue Engineering;Toxic effect;transcriptomics;Treatment Efficacy;tumor;Tyrosine Kinase Inhibitor;vascular contributions;Vascular Diseases;Vascular Endothelial Cell;Whole Blood;Wing

PROJECT_TITLE: Modeling Tyrosine Kinase Inhibitor-Induced Vascular Dysfunction Using Human iPSCs

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Dissemination and Implementation Research;Health Services;Neurodegenerative;Palliative Care;Patient Safety

PHR: PROJECT NARRATIVE Millions of Americans living with serious illness, and particularly those with Alzheimer's Disease and Related Dementias, experience burdensome care that is misaligned with their goals and preferences. Palliative care improves patient- and family-centered, clinical, and economic outcomes, but many never receive such care. This pragmatic trial will test a simple intervention embedded within the electronic health record that gently nudges clinicians to provide palliative care themselves or engage experts for hospitalized patients with serious illness, and will identify factors that affect clinicians' decisions regarding palliative care delivery.

PI_NAMEs: COURTRIGHT, KATHERINE RINALDI (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;Adopted;Affect;Age;Alzheimer's disease patient;Alzheimer's disease related dementia;American;behavior change;Behavior Therapy;Behavioral;care delivery;care seeking;care systems;Caring;Cessation of life;Characteristics;Clinical;clinical predictors;Cluster randomized trial;cohort;Communication;Consolidated Framework for Implementation Research;Consult;Consultations;contextual factors;cost;Data;Decision Making;design;Diagnosis;Documentation;economic outcome;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;Electronic Health Record;Environment;Equity;experience;Face;Family;Future;Goals;Guidelines;Health system;Heterogeneity;high risk;hospital care;Hospitalization;Hospitals;Hybrids;implementation framework;implementation strategy;improved;Inequity;innovation;inpatient service;Inpatients;insight;Intervention;intervention delivery;Intervention Studies;Interview;Investments;Knowledge;Malignant Neoplasms;medical specialties;Methods;Modeling;mortality;mortality risk;multiple chronic conditions;novel;Palliative Care;Patient Care;patient oriented;Patient Outcomes Assessments;patient subsets;Patient-Focused Outcomes;Patients;Pilot Projects;pragmatic trial;predictive modeling;predictive tools;preference;primary care clinician;primary outcome;Process;Prognosis;prognostic;programs;provider behavior;psychologic;Quality of life;Race;Randomized;randomized trial;Recommendation;Resources;response;Sampling;Science;secondary outcome;Services;Specialist;Specific qualifier value;Subgroup;symptom treatment;Symptoms;Testing;therapy development;treatment effect;United States National Institutes of Health;uptake

PROJECT_TITLE: Leveraging the electronic health record and behavioral nudges to promote primary and specialist palliative care for inpatients with serious illness: A pragmatic trial


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE  Cell reprogramming represents a major advancement in biology, and has wide applications in regenerative medicine, disease modeling and drug screening. Our multidisciplinary team will integrate state-of-art technologies and innovative approaches to elucidate how biophysically-induced nuclear deformation regulates 3D chromatin remodeling, epigenetic changes, the efficiency of induced neuronal reprogramming and CRISPR-mediated gene editing efficiency.

PI_NAMEs: LI, SONG  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: 3-Dimensional;Autologous;Biology;Biomedical Technology;Biophysics;Biosensor;Brain;cell growth;Cell Nucleus;Cell Physiology;Cell Reprogramming;Cells;cellular engineering;Chromatin;chromatin remodeling;Chromatin Structure;Clustered Regularly Interspaced Short Palindromic Repeats;Cues;design;Disease;disease model;Dissociation;DNA;DNA Methylation;drug discovery;Drug Screening;Epigenetic Process;epigenetic profiling;epigenetic regulation;epigenomics;fabrication;Fibroblasts;Gene Activation;Gene Expression;Genes;Genome;genome-wide;Genomics;Heterochromatin;Histones;improved;Individual;Induced Neurons;Injury;innovation;insight;Maps;Mechanics;Mediating;Methods;microdevice;Microfluidic Microchips;Microfluidics;migration;Molecular Conformation;multidisciplinary;multiple omics;Nerve Tissue;Nervous System Disorder;Neurons;Neurosciences;Nuclear;Nuclear Lamina;Patients;Peripheral;permissiveness;Process;Protocols documentation;Publications;Regenerative Medicine;Regulation;response;Role;scale up;Site;Somatic Cell;Source;Spinal Cord;Technology;Testing;Three-dimensional analysis;Tissue Engineering;transcription factor;transcriptomic profiling;Translations;Work

PROJECT_TITLE: Mechanopriming for cell engineering

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Diabetes;Machine Learning and Artificial Intelligence;Regenerative Medicine;Wound Healing and Care

ORG_DEPT: SURGERY

PHR: NARRATIVE Diabetes is associated with significant impairments in wound healing which can be attributed in part to alterations in the “cellular ecology” of local cell populations; however, the role of external mechanical forces in modulating these cell population dynamics within the wound environment remains poorly understood. Our fundamental hypothesis is that local tissue mechanical forces contribute to the disruption of cellular ecology in diabetic wound healing and that mitigation of these forces can improve healing. This proposal focuses on identifying the mechanisms leading to altered subpopulations in diabetic human and mouse wound healing, and using real world data (RWD) to translate these findings to develop clinical strategies to treat non-healing diabetic wounds.

PI_NAMEs: JANUSZYK, MICHAEL  (contact)

PROJECT_TERMS: Algorithms;Animal Model;Automobile Driving;Biology;blood vessel development;Blood Vessels;career;cell behavior;Cells;Chronic;Cicatrix;Clinical;clinical training;Data;Databases;Debridement;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic ulcer;diabetic wound healing;diagnostic biomarker;Ecology;efficacy evaluation;electronic health data;Electronic Health Record;electronic health record system;Engineering;Environment;Evaluation;Fibroblasts;Funding;Future;healing;Human;Impaired healing;Impaired wound healing;Impairment;improved;In Vitro;information model;interest;Kinetics;limb amputation;Lower Extremity;Machine Learning;machine learning method;mechanical force;Mechanics;Medical Research;Methodology;Modeling;Modernization;mouse model;Mus;neovascularization;next generation sequencing;non-diabetic;non-healing wounds;novel;Outpatients;Pathologic;Pathology;Patients;Population;Population Dynamics;Postdoctoral Fellow;predictive modeling;pressure;Process;Recommendation;Research;Research Training;response;Role;routine care;Sampling;Scientist;single cell analysis;single cell sequencing;single-cell RNA sequencing;Skin;skin ulcer;Splint Device;stem cells;System;Techniques;Technology;Therapeutic;Time;tissue injury;Tissues;Translating;Treatment Efficacy;treatment strategy;United States;United States National Institutes of Health;Visit;wasting;Work;wound;wound care;wound closure;wound environment;wound healing;Wound models;wound treatment

PROJECT_TITLE: Elucidating the role of mechanical forces in diabetic wound healing

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Asthma;Genetics;Lung;Neonatal Respiratory Distress;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative: The incidence of premature birth (delivery more than three weeks early) is increasing worldwide. Bronchopulmonary dysplasia (BPD) and other respiratory problems are major long-term consequences of very premature birth resulting in lifelong breathing problems, including wheezing and bronchoconstriction, with immense socioeconomic costs. These data will contribute to our understanding of BPD breathing problems, ways to treat those problems, and potentially prevent or decrease the severity of BPD itself; improving thousands of lives annually.

PI_NAMEs: RAFFAY, THOMAS MICHAEL (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Adolescent;Adrenergic Agonists;Adult;Air;Airway Disease;airway epithelium;airway hyperresponsiveness;Alveolar;alveolar epithelium;Alveolar Macrophages;Animal Model;Anti-Inflammatory Agents;Antioxidants;Arteries;Asthma;Attenuated;Breathing;Bronchoconstriction;Bronchodilator Agents;Bronchopulmonary Dysplasia;Cardiopulmonary;Cardiovascular Diseases;Catabolism;Cell Nucleus;Cells;Child;Childhood;Chronic;Chronic Obstructive Pulmonary Disease;Clinical;Complication;cost;cost estimate;Cre-LoxP;Crossbreeding;Cystic Fibrosis;Data;Development;Disease;Down-Regulation;early onset;economic cost;enzyme activity;Enzymes;Epithelial Cells;Epithelium;extreme prematurity;Face;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;Glutathione;Growth;Growth Factor;Hyperoxia;hypertensive;Hypertrophy;Immune;improved;In Vitro;in vivo;in vivo evaluation;Incidence;Inflammation;Inflammatory;Inhalation;inhibitor;Ions;Knock-out;Knockout Mice;LoxP-flanked allele;Lung;Lung Diseases;Measures;Metalloproteins;MicroRNAs;Modeling;Molecular;Molecular Target;mortality;mortality risk;mouse model;Mus;Muscle relaxants;Myelogenous;Myeloid Cells;Neonatal;neonatal airway;Neonatal Hyperoxic Injury;Neonatal lung;Newborn Animals;Newly Diagnosed;Nitric Oxide Synthase;normoxia;novel therapeutics;Organ;Oxidants;Oxidoreductase;Oxygen;Pathway interactions;Patients;pharmacologic;Phenotype;Premature Birth;Premature Infant;Preparation;preterm newborn;Prevalence;prevent;Property;Proteomics;Publishing;Pulmonary Hypertension;receptor;respiratory;Respiratory Disease;response;Right Ventricular Hypertrophy;Risk;Role;S-Nitrosoglutathione;S-Nitrosothiols;Severities;Signaling Molecule;single nucleus RNA-sequencing;Slice;Smooth Muscle;Smooth Muscle Myocytes;socioeconomics;Source;Structure of parenchyma of lung;Symptoms;Testing;Thick;transcription factor;United States;Wheezing;Wild Type Mouse

PROJECT_TITLE: S-Nitrosoglutathione therapy for oxidant disease of the neonatal airways and lung

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

PHR: Age-related macular degeneration (AMD) is thought to involve an overactive complement system in the posterior pole of the eye. We have developed and validated a targeted AP inhibitor as a possible therapeutic agent for the treatment of AMD using AAV vector therapy, and an antibody to monitor complement activation in vivo. Here we will further develop and extend our two approaches to testing in human iPSC-RPE cultures.

PI_NAMEs: ROHRER, BAERBEL  (contact)

PROJECT_TERMS: 3-Dimensional;adeno-associated viral vector;Affect;Age;Age related macular degeneration;Alternative Complement Pathway;American;Animal Model;Animals;Antibodies;Binding;Biological Assay;Blindness;Bruch's basal membrane structure;Caring;Cells;Choroid;Choroidal Neovascularization;Chromosome 1;Chromosome 10;Clinical;clinical application;comparative efficacy;Complement;Complement 3 Convertase;Complement 3a;Complement 3d Receptors;Complement Activation;complement C3d,g;Complement Factor D;Complement Factor H;complement system;Data;Deposition;design;Development;Diagnosis;diagnostic tool;Disease;disorder prevention;Dyes;Early treatment;effective therapy;efficacy evaluation;efficacy testing;Eye;FDA approved;Fluorescence;gene therapy;Genetic;Genetic Polymorphism;genetic risk factor;Genetic study;Genotype;geographic atrophy;Goals;Human;human induced pluripotent stem cells;human model;Image;Imaging technology;improved;In Vitro;in vivo;in vivo imaging;Incidence;induced pluripotent stem cell;Inflammation;inhibitor;Intervention;intravitreal injection;Learning;Ligands;Liquid substance;Liver;Location;Macular degeneration;Measures;Mediating;Membrane;Methods;Molecular Abnormality;Monitor;mouse model;Mus;Mutation;nanobodies;Nonexudative age-related macular degeneration;Pathologic;Pathology;Pathway interactions;Patients;Penetration;Peptide Hydrolases;Pharmaceutical Preparations;phase III trial;Population;Prevalence;Prevention;Progressive Disease;Proteins;Quality of life;Risk;Risk Factors;Signal Transduction;Site;Smoking;System;Testing;Therapeutic;Therapeutic Agents;three dimensional cell culture;tissue/cell culture;Tissues;tool;Treatment Efficacy;Variant;vector control;Veterans;wasting;Work

PROJECT_TITLE: Complement Factor H-based Therapeutic Strategies in Macular Degeneration

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because cholangiopathies, which often affect extrahepatic bile ducts, are poorly understood and, therefore, have no effective treatment options. This project will unveil cellular and molecular mechanisms underlying extrahepatic bile duct responses to injury and inform potential strategies for treatment of cholangiopathies and prevention of their complications. Thus, the proposed research is relevant to the NIH mission that pertains to improvement of people’s health and quality of life.

PI_NAMEs: RAZUMILAVA, NATALIYA  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Acute;Affect;Archives;ATAC-seq;Attenuated;Automobile Driving;bile duct;Biliary;Binding Sites;Cells;chemokine;Chemotactic Factors;Cholangiocarcinoma;cholangiocyte;Chromatin;Cirrhosis;Coculture Techniques;Complex;CXCL1 gene;Data;Death Rate;Development;Disease;Disease Marker;DNA;effective therapy;Epitopes;Erinaceidae;Event;Extrahepatic Bile Ducts;Fibroblasts;Foundations;Gene Expression;Genes;Genetic;Genetic Transcription;GLI gene;Goals;Health;Homeostasis;Hour;Human;human disease;Immune;improved;improved outcome;In Vitro;in vivo;Inflammation;Inflammatory Response;inhibitor;injured;Injury;intercellular communication;interest;Interleukin-1 beta;Knowledge;Life;Ligands;Ligation;Link;loss of function;Malignant Neoplasms;Maps;Marker Discovery;Measures;Mediating;Mediator;migration;Mission;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;neutrophil;Neutrophil Infiltration;novel;novel therapeutic intervention;Obstruction;Organoids;Pathogenesis;Pathway interactions;Patients;Persons;pharmacologic;Prevention;programs;Proliferating;Proteins;Public Health;Publishing;Quality of life;recruit;Research;response;response to injury;Role;Signal Transduction;single-cell RNA sequencing;smoothened signaling pathway;Stromal Cells;Testing;Therapeutic;therapeutic target;Tissues;transcription factor;transcriptome sequencing;treatment strategy;United States National Institutes of Health;Up-Regulation

PROJECT_TITLE: Mechanisms regulating cellular crosstalk in extrahepatic bile duct responses to injury

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Chromatin regulatory proteins are a major class of gene products for which sequence variants are associated with autism spectrum disorders and intellectual disability; however, the functional consequences of these mutations for brain development remain poorly understood. This proposal will take advantage of both mouse in vivo and human neuronal culture models to identify molecular mechanisms that underlie intellectual disability associated with frameshift mutations in the linker histone H1.4. These data will advance understanding of how mutations in chromatin regulatory proteins lead to neurodevelopmental disorders.

PI_NAMEs: WEST, ANNE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: 3-Dimensional;Address;Alleles;Antibodies;Anxiety;Architecture;autism spectrum disorder;Binding;Binding Proteins;Binding Sites;Biochemical;Biochemical Genetics;Bioinformatics;Biological Assay;Biological Models;Biological Process;Biology;Biotin;bone;Brain;C-terminal;Categories;Cell Nucleus;Cell Physiology;Cellular Morphology;Chromatin;chromatin immunoprecipitation;chromosome conformation capture;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;comparative;Data;Data Analyses;Defect;Development;Developmental Gene;DNA Binding;Dominant-Negative Mutation;Epitopes;Facies;Family;Family member;Foundations;Frameshift Mutation;Future;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene product;Genes;Genetic;genetic approach;genetic regulatory protein;Genetic Transcription;genome-wide;Heterozygote;Hippocampus;Histone H1;Histones;Human;Impairment;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;insight;Intellectual functioning disability;Knock-in;Knowledge;Lead;Ligase;Mediating;member;Methods;Modeling;Molecular;Molecular Conformation;Molecular Genetics;multi-electrode arrays;Mus;Muscle hypotonia;mutant;Mutate;Mutation;N-terminal;neurodevelopment;Neurodevelopmental Disorder;neuron development;Neuronal Differentiation;Neurons;Neuropeptides;novel;Online Mendelian Inheritance In Man;Phenotype;Post-Translational Protein Processing;Post-Translational Regulation;postmitotic;Process;programs;Protein Truncation;Proteins;Proteomics;Rahman Syndrome;rare genetic disorder;Rattus;Regulation;Series;severe intellectual disability;Signal Transduction;Specificity;Structure;Synapses;synaptic function;Tail;Testing;Time;transcriptome sequencing;Variant;Vision

PROJECT_TITLE: Chromatin dysregulation in neurodevelopmental disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (57)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE To address persistent disparities in combusted tobacco product use, novel communication approaches through digital channels are needed. Using an innovative combination of qualitative, eye tracking, and quantitative (discrete choice experiment, randomized clinical trial) studies, we will develop and test messages to reach low- SES smokers. Results will will help eliminate tobacco-related disparities and increase the effectiveness of tobacco educational messages among the population for whom anti-tobacco messages have not been optimally effective.

PI_NAMEs: POPOVA, LYUDMILA  (contact)

PROGRAM_OFFICER_NAME: CHOU, WEN-YING

PROJECT_TERMS: Address;Age;Arousal;Attention;Behavior;Behavioral;behavioral outcome;Belief;Cessation of life;Cigar;Cigarette;Communication;comparison control;Complex;design;digital;digital media;Disease;Disparity;Economically Deprived Population;Education;Effectiveness;Emotional;Environment;experience;experimental study;Exposure to;Focus Groups;Government regulations;health communication;health equity;inclusion criteria;informant;innovation;Intention;Interview;low socioeconomic status;Measures;Menthol;Misinformation;novel;novel strategies;Participant;Persons;Police;Policies;Population;Proliferating;Public Health;Race;Randomized;randomized, clinical trials;recruit;reduce tobacco use;Regulation;Research;Risk;Sales;Sampling;Smoker;Smoking;social media;socioeconomic disadvantage;Socioeconomic Status;success;Testing;Tobacco;tobacco products;tobacco regulation;Tobacco use;visual tracking;young adult

PROJECT_TITLE: Communicating for Health Equity in Digital Environments

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-J (02)]


NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Freezing of gait (FOG) is one of the most debilitating features of Parkinson’s disease (PD) and occurs most often during self-initiated (uncued) transitions in movement (e.g. standing to walking, straight-line walking to turning), but can be overcome (and transition performance improved) with the provision of an external sensory cue. This study will use a variety of neurophysiological techniques to investigate the role that three neural systems (vestibular, cortical, and basal ganglia) play in the pathogenesis of impaired transitions from standing-to-walking in people with PD, and how external cues affect the dynamics of these systems to improve movement performance. This project will provide unique insight into the alterations in brain activity associated with FOG and cueing, which may then be translated into treatments to prevent FOG and improve quality of life in people with PD.

PI_NAMEs: HUFFMASTER, SOMMER L (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Affect;American;Automobile Driving;Basal Ganglia;behavior measurement;Biological Markers;Biomechanics;Brain;Brain region;Communication;Complex;corticofugal system;Cues;Data;deep brain stimulator;Development;dynamic system;effective therapy;Electroencephalography;Electromyography;Equilibrium;experience;fall risk;falls;Freezing;Functional disorder;Gait;Gait abnormality;Ganglia;Globus Pallidus;Goals;impaired capacity;Impairment;Implant;improved;Incidence;Individual;insight;Intervention;kinematics;Lead;Leg;Link;Locomotion;Measurement;Measures;Mediating;Methods;Mobility decline;Morbidity - disease rate;Motor;Motor Cortex;motor impairment;Movement;Muscle;Musculoskeletal Equilibrium;National Institute of Neurological Disorders and Stroke;neural;Neurologic;neuromechanism;neurophysiology;neuroregulation;novel therapeutics;Parkinson Disease;Participant;Pathogenesis;Performance;Persons;Play;Postural adjustments;Posture;prevent;Quality of life;Reaction;Resistance development;Resolution;Role;Sensory;sensory stimulus;Severities;Standardization;Surface;System;Techniques;Testing;therapy development;Translating;vestibular system;Walking;wearable device;wearable sensor technology;wireless

PROJECT_TITLE: Neurophysiology of movement transitions in Parkinson's disease with freezing of gait

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Noise is an environmental stressor that changes the physiology of the body and also damages the cochlea. Stress elicits an integrated response in the ear that involves the central nervous system, the sympathetic nervous system, cochlear circuitry, and the immune system. Understanding how central and peripheral stress response neurons impact cochlear function and resilience is important for finding ways to limit the effects of noise and other sources of stress.

PI_NAMEs: GOODRICH, LISA  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Ablation;Acoustic Trauma;Action Potentials;Adrenergic Receptor;Anatomy;Animals;Auditory;awake;Axon;Back;Behavior;biological adaptation to stress;Biological Assay;Blood flow;Brain Stem;Catalogs;Cells;Central Nervous System;Cervical;Cessation of life;Cochlea;Collaborations;Complex;Detection;Ear;Electrophysiology (science);Emotional;Environment;environmental stressor;experimental study;Exposure to;Fiber;fighting;flexibility;Frequencies;Genetic;genetic approach;Goals;Hair Cells;Health;Human;Immune;Immune response;Immune system;immunoregulation;improved;In Situ;in vivo;Induced Neurons;Inflammatory Response;Knowledge;Labyrinth;Lateral;Learning;Loudness;Macrophage;Maintenance;Maps;Medial;Methods;Modernization;Molecular;mouse genetics;Mus;Nature;nerve supply;neural;Neuroimmune;Neurons;neuropeptide Y;Neuropeptides;Noise;noise exposure;Noise-Induced Hearing Loss;noradrenergic;Norepinephrine;Organ of Corti;Outer Hair Cells;Peptides;Peripheral;Physiology;Population;presynaptic;prevent;Process;Production;Property;recruit;resilience;response;Role;Shapes;single-cell RNA sequencing;Site;Slice;sound;Source;spiral ganglion;Spiral Lamina;Stimulus;Stress;stressor;Structure of stellate ganglion;Structure of superior cervical ganglion;Surveys;Swelling;Sympathetic Ganglia;Sympathetic Nervous System;Synapses;Synaptophysin;System;Testing;Tissues;tool;transmission process;traumatic event;urocortin;Viral;Work

PROJECT_TITLE: Neuronal control of cochlear stress responses

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Food Allergies;Immunization;Immunotherapy;Nutrition;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Peanut and tree nut allergy is increasing in prevalence and poses a significant public health risk, as patients can develop life-threatening reactions. Antibodies that can bind to allergens underlie both clinical reactions to food allergens and tolerance after treatment. Our project focuses on understanding how these allergens are recognized by antibodies in similar ways by many allergic patients to contribute to our understanding of how food allergies begin and how we can develop new targeted therapies.

PI_NAMEs: PATIL, SARITA U (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Address;Adult;Affect;Affinity;Aftercare;airborne allergen;Allergens;Allergic;Allergy to peanuts;Anaphylaxis;Antibodies;Antibody Affinity;Antibody Binding Sites;Antibody Repertoire;Antibody Therapy;Antigens;B-Lymphocytes;Base Sequence;Binding;Child;Clinical;clinically relevant;Cloning;cohort;Collaborations;Communicable Diseases;Cross-Sectional Studies;Data;Development;Disease;Effector Cell;Enzyme-Linked Immunosorbent Assay;Epitopes;Evolution;Flow Cytometry;food allergen;Food Hypersensitivity;Frequencies;Genetic Recombination;Germ Lines;Goals;HIV;Hypersensitivity;IgE;Immunodominant Epitopes;Immunoglobulin G;Immunotherapy;Incidence;Individual;Influenza;insight;Interferometry;Intervention;Life;Life Experience;Modeling;Molecular Conformation;Monoclonal Antibodies;Mutagenesis;Mutate;neutralizing antibody;new therapeutic target;next generation;Nut Hypersensitivity;Nuts;oral immunotherapy;Pathway interactions;Patients;Population;Positioning Attribute;Prevalence;Public Health;Reaction;Recombinant Antibody;Reporting;Risk;Serum;single cell sequencing;Site;Site-Directed Mutagenesis;Testing;Therapeutic antibodies;Trees;Work;X-Ray Crystallography

PROJECT_TITLE: Convergent allergen-specific antibodies in food allergy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (57)]


ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: PROJECT NARRATIVE We propose a cross-disciplinary training program that brings together regeneration biologists, neurophysiologists, and clinician researchers to form mentorship teams within the largest medical research center in the world: The Texas Medical Center. This training program will foster a new generation of scientists who will in turn help build a new frontier of biology: neural control of organ degeneration and regeneration.

PI_NAMEs: HORNER, PHILIP J (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Administrative Supplement

PROJECT_TITLE: T32 Administrative Supplement


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Physical Activity;Pregnancy;Prevention;Sleep Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE This grant aims to utilize data from the National Health and Nutrition Survey (NHANES) linked Medicaid data to create a novel preconception cohort and study the role of preconception lifestyle factors on pregnancy outcomes. The proposed study will evaluate the role of preconception dietary factors, sleep and physical activity, and weight loss attempts and strategies on adverse pregnancy outcomes. The data obtained from this study will provide valuable insights into the role of preconception health factors improving pregnancy outcomes and can inform the development of evidence-based preconception care guidelines.

PI_NAMEs: CANIGLIA, ELLEN CHRISTINA;HINKLE, STEFANIE NICOLE (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;adverse pregnancy outcome;Age;aged;Alternative Health;Birth;Body Composition;Body mass index;Body Weight;Body Weight decreased;Cesarean section;Child;Classification;cohort;Conceptions;Confounding Factors (Epidemiology);DASH diet;Data;Development;Diagnosis;Diet;Dietary Factors;Dietary Practices;Eating;Epidemiologic Methods;evidence base;Fatty acid glycerol esters;Female;Fertility;Gestational Diabetes;Grant;Guidelines;Health;Health Surveys;Household;Hypertension;improved;indexing;Individual;innovation;insight;Intervention;Late pregnancy;Leisures;Life Style;lifestyle factors;Light;Link;Location;Low income;Low Income Population;Measures;Medicaid;Medicaid services;Mediterranean Diet;Metabolic;Methodology;moderate-to-vigorous physical activity;Morbidity - disease rate;Mothers;novel;Nutrition Surveys;Obesity;Participant;Patient Self-Report;phenotypic data;Physical activity;Placentation;Play;Pre-Eclampsia;Preconception Care;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnancy health;pregnancy hypertension;Pregnancy loss;Pregnancy Outcome;pregnant;Premature Birth;Prevention;Public Health;randomized trial;Recommendation;Regulation;reproductive;Risk;Risk Reduction;Role;sedentary;Selection Bias;Sleep;Sleep Disorders;sleep quality;subcutaneous;Thinness;Time;Transportation;unintended pregnancy;Visceral;Woman

PROJECT_TITLE: Utilizing the NHANES-Linked Medicaid Data to Understand the Role of Preconception Lifestyle Factors on Pregnancy Outcomes

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ADMINISTERING_IC: AT

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Complementary and Integrative Health;Dietary Supplements;Genetics;Human Genome;Natural Products

ORG_CITY: ATHENS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: PROJECT NARRATIVE Plants produce a plethora of medicinally important natural products that have significant potential to improve human health yet are often produced in low amounts, in complex mixtures, and/or cannot be produced in a sustainable or economic manner. Omics technologies enable the discovery of the biosynthetic genes of plant natural products which can then be employed in commercial production of medically relevant compounds. In this project, we will use state-of-the-art omics technologies to efficiently discover genes responsible for the biosynthesis of eight pharmacologically relevant compounds and utilize this knowledge to revitalize an old technology, plant cell culture, to enable robust, sustainable production of these products.

PI_NAMEs: BUELL, CAROL ROBIN (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Anabolism;Analgesics;Anti-Inflammatory Agents;Anti-malarials;anticancer activity;Antineoplastic Agents;ATAC-seq;Biological Assay;Bone callus;Botanicals;Candidate Disease Gene;candidate identification;Catharanthus roseus;Cell Culture System;Cell Culture Techniques;Cell Nucleus;cell type;Cells;Cellular biology;Chromatin;Chromosomes;Chromosomes, Human, 13-15;Clinical;clinical application;clinically relevant;Complex;Complex Mixtures;Cultured Cells;Data;Data Set;Development;drug development;Economics;empowerment;Engineering;experimental study;fitness;Flowers;Gene Cluster;Gene Combinations;gene discovery;Gene Expression;gene product;Generations;Genes;Genome;genome-wide;Genomic approach;Genomics;Hand;Health;Heterogeneity;Hi-C;Human;human disease;Improve Access;improved;Indole Alkaloids;innovation;interest;Knowledge;manufacturing facility;Mass Spectrum Analysis;Medical;Medicine;metabolic engineering;Metabolic Pathway;Metabolism;metabolomics;Methodology;microbial;miniaturize;Molecular Conformation;Monoterpenes;mRNA sequencing;multiple omics;Natural product discovery;Natural Products;next generation;Nicotiana;Organ;Paclitaxel;Pain;Pathway interactions;pharmacologic;Pharmacologic Substance;Plant Genes;Plant Genome;Plant Leaves;Plant natural product;Plants;Population;Production;reconstitution;Regulation;Regulatory Element;Renaissance;Resolution;Signal Transduction;single nucleus RNA-sequencing;stem;success;Suspension Culture;synthetic biology;System;Technology;Tissues;Tobacco;tool;transcription factor;transcriptomics;Vinblastine;Vinorelbine;Yeasts

PROJECT_TITLE: Multi-omics approaches to lower the barriers to sustainable production of plant natural products with relevance to human health

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]