NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

PHR: Project Narrative  Developing effective targeted therapies for cancer requires an accurate understanding of the proteins that sustain cancer growth, but some of these proteins can have multiple, and even unexpected functions. This proposal will investigate the multiple functions of CRAF, a key protein that sustains growth of a subset of lung cancers, but whose molecular function(s) remain contested. The discoveries made in this study will inform cancer drug development efforts by revealing how CRAF promotes tumor progression and how CRAF can be targeted to selectively kill cancer cells.

PI_NAMEs: WOODS, JAMES  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Active Sites;Adenine;Antineoplastic Agents;Attenuated;attenuation;base editing;base editor;Biological Assay;Biology;BRAF gene;cancer cell;Cancer cell line;cancer type;cell growth;Cell Line;Chemicals;Chemistry;Co-Immunoprecipitations;Complement;Complex;conflict resolution;Cytosine deaminase;Dana-Farber Cancer Institute;Development;dimer;Dimerization;drug development;drug discovery;Drug Targeting;Engineering;Environment;experimental study;Fellowship;follow-up;Future;Growth;Homo;In Situ;In Vitro;inhibitor;Institution;interest;Knock-out;Knowledge;KRAS2 gene;loss of function;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;meetings;Mentors;Mentorship;Methodology;Methods;Mitogen-Activated Protein Kinases;Modeling;Molecular;monomer;Mutagenesis;mutant;Mutate;Mutation;Nature;Normal Cell;novel;Oncogenic;overexpression;Pathway interactions;Phenotype;Phosphotransferases;Precision therapeutics;prevent;Protein Isoforms;protein protein interaction;Proteins;raf Kinases;RAS genes;Regulation;Research;Research Personnel;Role;scaffold;Scanning;Signal Transduction;Site;stoichiometry;Structure;Surface;targeted cancer therapy;Testing;theories;Therapeutic;therapeutic development;Time;Toxic effect;Training;tumor progression;Tumor Promotion;Tumor Subtype;Work

PROJECT_TITLE: Base editing to elucidate RAF regulation and signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04B-S (20)]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE The supramammillary area (SuM) is increasingly appreciated for its role in a variety of functions, including spatial and social novelty processing via its connections with the hippocampus. The hippocampus provides direct inhibitory input to the SuM, but the nature and function of the connectivity is unknown. The studies outlined in the proposal would provide important basic science groundwork for understanding this connectivity, with ultimate potential impacts for better understanding and treating a range of neurological disorders, including but not limited to temporal lobe epilepsy.

PI_NAMEs: KROOK-MAGNUSON, ESTHER  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Alzheimer's Disease;Animals;Anterior;Area;base;Basic Science;behavior test;Behavioral;Calcium;Calcium Signaling;Cells;Data;dentate gyrus;Disease;Dorsal;Electrophysiology (science);Feedback;Fiber;Health;Hippocampus;Immunohistochemistry;in vivo;inhibitory neuron;insight;Investigation;Label;Literature;Location;Memory impairment;Morphology;Nature;Nervous System Disorder;Neurons;Nitric Oxide Synthase Type I;novel;novelty processing;optogenetics;patch clamp;Performance;Photometry;Play;Population;Property;Publishing;response;Role;Shapes;Signal Transduction;Slice;social;Somatostatin;Specificity;Target Populations;Temporal Lobe Epilepsy;Testing;Time;Viral Vector;Work

PROJECT_TITLE: Inhibitory hippocampal projections to the Supramammillary area

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-T (02)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE MicroRNAs are small, noncoding RNAs that regulate the expression of more than half of human protein-coding genes and are crucial for proper production of blood and immune cells. MicroRNA levels can be tuned through a process called target-directed microRNA degradation, however, the role of this microRNA degradation in hematopoiesis (the generation of blood cell lineages from a hematopoietic stem cell) is unknown. This proposal will establish foundational knowledge about the role of this degradation process in mammalian hematopoiesis, with a focus on platelet-producing cells, which will identify potential therapeutic targets for platelet-related blood clotting conditions.

PI_NAMEs: ELCAVAGE, LARA  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Adult;Automobile Driving;Blood;Blood Cells;Blood coagulation;Blood Platelets;Bone Marrow Cytometry;Bone Marrow Transplantation;Cell Lineage;Cell model;cell type;Cells;Code;Complete Blood Count;conditional knockout;Cre lox recombination system;Cryoultramicrotomy;Data;Defect;Down-Regulation;Embryo;embryo tissue;Engraftment;Environment;experimental study;Femur;fetal;Fetal Liver;Flow Cytometry;Gene Expression;Gene Expression Profile;gene regulatory network;gene repression;Generations;Genes;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;hematopoietic differentiation;hematopoietic stem cell niche;Hematopoietic stem cells;Hemorrhage;Hepatocyte;Human;Immune;Immune System Diseases;Immunophenotyping;Impairment;Knock-out;Knockout Mice;Knowledge;Life;Literature;Lymphocyte;Mediating;Megakaryocytes;Megakaryocytopoieses;Messenger RNA;MicroRNAs;Modeling;monocyte;mouse model;Mus;novel;overexpression;Perinatal mortality demographics;Phenotype;Physiological;Platelet Count measurement;Population;posttranscriptional;Primary Cell Cultures;Process;Production;Proteins;Publishing;reconstitution;Regulation;Reporting;Repression;Role;Small RNA;Spleen;stem cell genes;stem cell population;stem cells;Suspensions;Therapeutic;therapeutic target;Thrombocytopenia;Thrombopoietin;transcriptome sequencing;Transplantation;Untranslated RNA;Work

PROJECT_TITLE: Characterization of the role of ZSWIM8 and target-directed microRNA degradation in hematopoiesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-B (20)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Drug Abuse (NIDA only);Emergency Care;Fentanyl Misuse and Addiction;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Substance Misuse;Wound Healing and Care

ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE The proposed study addresses NIDA’s Notice of Special Interest in xylazine, which has worsened the US opioid crisis and is associated with overdose risk, severe skin wound development, and withdrawal. Our understanding of xylazine’s effect on the health of people who use drugs is nascent and there is no widely available point-of- care test to identify patients exposed to fentanyl adulterated or associated with xylazine (FAAX). This study will use an exploratory, sequential, mixed methods design to understand how people who use FAAX experience and self-manage its effects and develop a natural language processing algorithm to identify FAAX-exposed emergency department patients that can be used to link patients to treatment and identify a population of FAAX- exposed patients’ EHR data upon which to explore further lines of inquiry.

PI_NAMEs: KELLY, PATRICK JOHN (contact)

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: 18 year old;addiction;Address;Adherence;Affect;Algorithms;Anticonvulsants;Apache;Autopsy;Behavioral;Behavioral Sciences;Big Data;career;Clinical;clinical practice;Code;Communities;Computing Methodologies;Coupled;Data;Data Sources;Decision Making;design;Detection;Development;Diagnostic;Dictionary;Drug user;effective therapy;Electronic Health Record;Emergency Care;Emergency Department patient;Emergency Medicine;Epidemiology;epidemiology study;evidence base;experience;Exposure to;Fellowship;Fentanyl;fentanyl use;Funding;Goals;Grant;Harm Reduction;Health;Health Care Costs;Health system;Hospitals;improved;Infiltration;informant;Information Systems;injection drug use;insight;interest;Interview;Knowledge;large datasets;Leadership;limb loss;Link;manufacture;Medical;medication for opioid use disorder;Medicine;Mentors;Mentorship;Methodology;Methods;mortality;Naloxone;National Institute of Drug Abuse;Natural Language Processing;novel;Opioid;Opioid Antagonist;opioid epidemic;opioid injection;opioid use;opioid use disorder;Outcome;Overdose;overdose risk;Patient Recruitments;Patients;Persons;Pharmaceutical Preparations;point of care;point of care testing;Population;Population Research;Positioning Attribute;Prevalence;Productivity;programs;Provider;public health priorities;Recording of previous events;Reducing Agents;Research;Research Methodology;Research Personnel;Rhode Island;Scientist;sedative;Self Management;skills;skin wound;substance use;surveillance data;Symptoms;System;Techniques;Testing;Text;Time;Training;treatment choice;treatment services;United States National Institutes of Health;uptake;Vocabulary;Withdrawal;Withdrawal Symptom;wound;Xylazine

PROJECT_TITLE: Community and big-data system approaches to identifying and understanding the health impact of xylazine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: Boston

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: Project narrative Mutations in the four main voltage-gated sodium channels expressed in the brain are leading causes of pediatric epilepsies, with mutations in SCN8A accounting for up to 1% of all diagnoses. Voltage-gated sodium channels are highly conserved and undergo developmentally regulated mutually exclusive alternative splicing of exons 5N and 5A, which encode different versions of the voltage sensor in domain 1. The goal of this proposal is to investigate the function of exons 5N and 5A in Scn8a in neuronal activity and seizure susceptibility using splice-switching ASOs, determine if these ASOs can be used as a treatment for mutations in exon 5N in a new mouse model of Scn8a, and dissect the mechanism that regulates the splicing switch.

PI_NAMEs: BURGE, CHRISTOPHER B;DULLA, CHRIS G;OUDIN, MADELEINE JULIE (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Accounting;Action Potentials;Adult;Affect;Alternative Splicing;American;anti-epileptic agents;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Axon;Binding;Birth;Brain;candidate identification;Cells;Child;Childhood;childhood epilepsy;Climacteric;Complementary DNA;Data;design;Development;developmental epileptic encephalopathy;Diagnosis;disability risk;Disease;Disease Progression;Dissection;Distal;efficacy evaluation;efficacy testing;Electrophysiology (science);Elements;Ensure;Epilepsy;Exons;FDA approved;Functional disorder;gain of function mutation;Generations;Genes;Goals;high risk;Human;improved;In Vitro;in vivo;Intellectual functioning disability;Intractable Epilepsy;knock-down;Knowledge;Messenger RNA;Microelectrodes;Modeling;mortality;mortality risk;mouse model;Mus;Mutagenesis;mutant;Mutate;Mutation;Neonatal;neuroblastoma cell;Neurologic;Neuromuscular Diseases;neuron development;neuronal excitability;Neurons;novel;novel therapeutic intervention;Pathogenicity;Patients;Pattern;physically handicapped;Predisposition;prevent;protein expression;protein function;Protein Isoforms;Proteins;Quality of life;Ranvier's Nodes;Refractory;Regulation;response;RNA;RNA Binding;RNA Interference;RNA Splicing;Role;SCN8A gene;Seizures;sensor;skills;Slice;Sodium;Sodium Channel;Sodium Channel Blockers;Therapeutic;Time;Validation;voltage;Wild Type Mouse

PROJECT_TITLE: Targeting Alternative Splicing of Sodium Channels to Treat Pediatric Developmental Epileptic Encephalopathies

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE While rodents and primates have been extensively used as model systems for studying visual processing, a major dichotomy remains that their visual systems are optimized to perform different tasks, such as detecting movement versus detecting fine special pattern. Tree shrew lies phylogenetically between rodents and primates, and has a sophisticated chromatic visual system that is similar to primates; thus lending itself as an ideal model system to resolve this dichotomy and identify cell types and genes involved in retinal pathologies. The proposed studies will establish tree shrew as a model system for studying how visual signals are processed in distinct retinal circuits and routed to higher brain areas, producing distinct visual specializations in different species.

PI_NAMEs: ROY, SUVA  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Animals;Area;Biological Models;Biotinylation;Brain;Cell Physiology;cell type;Cells;Classification;Color;color processing;Color Visions;Comparative Biology;Comparative Study;Cone;density;Electrophysiology (science);Endowment;Exhibits;experimental study;Eye;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic analysis;genetic makeup;Genetic Screening;Genetic Variation;improved;Incentives;Individual;insight;Ipsilateral;Label;Light;Mammals;Measurement;Measures;Mentors;Modeling;Molecular;molecular marker;Morphology;Movement;multi-electrode arrays;Mus;neural;neural circuit;Neurophysiology - biologic function;Neurosciences;new technology;novel;optogenetics;orientation selectivity;Pathology;Pattern;Peripheral;pharmacologic;Photoreceptors;Phylogenetic Analysis;Population;Primates;Process;Property;receptive field;Research;response;Retina;Retinal Ganglion Cells;retinal stimulation;retinogeniculate;Rodent;Shapes;Signal Transduction;single-cell RNA sequencing;species difference;Structure;Synapses;Techniques;Testing;Tissue-Specific Gene Expression;tool;Tracer;transcriptomics;Transfection;Translating;Tupaiidae;Variant;Viral;Vision;Visual;Visual Cortex;Visual Pathways;visual processing;visual stimulus;Visual System;Work

PROJECT_TITLE: Bridging gap in comparative biology using the tree shrew visual system

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Studies from the Zaire Ebola virus (EBOV) outbreak in West Africa suggested that the FDA-approved EBOV vaccine can be highly effective; however, more recent data from the Democratic Republic of the Congo revealed that EBOV vaccine failure rates may be as high as 30%. We postulate that acute Plasmodium parasitemia that is prevalent in Central Africa decreases immune responses to the FDA-approved vaccine. Here, we use a mouse model to mechanistically define the effect of acute Plasmodium infection on the efficacy of EBOV vaccine.

PI_NAMEs: ELLIFF, JONAH  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acute;Address;Africa;Antibodies;Antibody Response;Antigens;Apoptosis;Attenuated;Bioinformatics;Blood;career;Cell Physiology;Central Africa;Clinical;clinically actionable;clinically relevant;Communicable Diseases;Data;Death Rate;Defect;Democratic Republic of the Congo;Disease Outbreaks;draining lymph node;Ebola Vaccines;Ebola virus;Event;Exhibits;experience;Faculty;Failure;Family;FDA approved;Fellowship;Filovirus;Generations;Glycoproteins;Goals;Guinea;Human;Humoral Immunities;Immune;Immune response;Immunity;Immunize;immunogenicity;Immunoglobulin G;Immunology;Impairment;improved;Infection;Inflammatory;inflammatory milieu;Inflammatory Response;interest;Internal Medicine;Intramuscular;Investigation;Iowa;Knowledge;Licensing;lymph nodes;Malaria;Mediating;Medical;member;Mentors;Mentorship;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Output;Parasitemia;Parasites;Participant;particle;Pathogenicity;Peripheral;Physicians;Plasma Cells;Plasmodium;Plasmodium falciparum;Population;Porosity;Positioning Attribute;Preparation;prevent;protective efficacy;Public Health;Publishing;Recombinant Vaccines;Research;Research Personnel;Residencies;response;Scientist;skills;Spleen;Structure of germinal center of lymph node;success;Techniques;Testing;Time;trafficking;Training;Training Programs;transcriptomics;transmission process;Universities;Vaccination;vaccine efficacy;vaccine failure;vaccine immunogenicity;vaccine response;Vaccines;vaccinology;Viral;Viral Hemorrhagic Fevers;virology;Virus Diseases;virus host interaction;Zaire Ebola virus

PROJECT_TITLE: Evaluating the impact of malaria on immunogenicity of the Ebola virus vaccine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Pain Research

ORG_CITY: PITTSBURGH

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Opportunistic and invasive fungal infections (i.e., C. albicans) are remarkably prevalent today and pose a significant threat to hospitalized and immunocompromised patients globally. Although pain-sensing neurons and the neuropeptide CGRP have been implicated as drivers of antifungal immunity, the cell network (i.e., cellular sources of and responders to CGRP) responsible for this pathway remains poorly defined. This proposal will combine the use of mouse models and computational approaches to investigate the role of CGRP during anti- Candida immunity at the skin, with our results paving the way for novel antifungal therapeutics that leverage neuroimmune interactions.

PI_NAMEs: GILLIS, JACOB  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Ablation;antagonist;anti-fungal agents;Award;Bone Marrow;Calcitonin Gene-Related Peptide;Candida;Candida albicans;Candidiasis;career;Cell Communication;Cell Separation;Cells;Cessation of life;Circulation;Clinical Medicine;Communities;congenic;Cutaneous;cytokine;Data;Dendritic Cells;Dermal;Development;Effector Cell;Elements;Flow Cytometry;Funding;Future;Gene Expression Profile;Genetic Transcription;Growth;Hospitalization;Host Defense;IL17 gene;Immune;Immune response;Immune system;Immunity;Immunocompromised Host;Immunology;improved;In Situ;Infection;Infectious Skin Diseases;Inflammation;Inflammatory;interleukin-23;Invaded;K-Series Research Career Programs;Knowledge;Life;Mediating;Modeling;mortality;mouse model;multiple omics;Mus;Mycoses;Neurogenic Inflammation;Neuroimmune;neuroimmunology;Neuropeptides;neutrophil;Nociceptors;novel;novel therapeutics;pathogen;Pathway interactions;Patients;Phenotype;Physicians;Population;Production;progenitor;programs;prophylactic;Proteins;RAMP1;receptor;reconstitution;Reporting;Residencies;Resistant candida;Resolution;response;Role;Scientist;Signal Transduction;single-cell RNA sequencing;Site;Skin;small molecule;Source;Streptococcus pyogenes;subcutaneous;System;T-Lymphocyte;Techniques;Testing;Therapeutic;Tissues;Training;Transcript;transcriptomics;Vulnerable Populations

PROJECT_TITLE: Defining the role(s) of CGRPα during cutaneous antifungal immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

PHR: PROJECT NARRATIVE Medications for opioid use disorder (i.e., buprenorphine, methadone) are the most effective treatment interventions that can be provided to individuals with opioid use disorder during incarceration to reduce morbidity and mortality, although it is unknown if the onset of ubiquitous fentanyl use has altered the uses of medication and associated outcomes. The proposed study will lead to (1) the first estimates of uses of medications for opioid use disorder among incarcerated populations before and after the onset of the fentanyl-dominant drug supply, (2) the identification of continued gaps in medications for opioid use disorder delivery at the individual, interpersonal, community, and structural levels, and (3) the dissemination of findings to inform data-driven best practices for medication delivery in carceral settings. This research has the potential to improve the healthcare delivery systems for individuals with opioid use disorder who are incarcerated and recently released.

PI_NAMEs: BAILEY, AMELIA  (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: addiction;Address;Adherence;Adult;Applications Grants;Award;Buprenorphine;career;Characteristics;Communities;community-level factor;Country;Data;Data Analyses;Data Collection;Demographic Factors;Dependence;design;Development;disease transmission;dosage;effective therapy;evidence base;Evidence based intervention;Evidence based treatment;experience;Face;FDA approved;Fellowship;Fentanyl;fentanyl use;Gender;General Population;Goals;Health;Health behavior;health care delivery;health service use;Illicit Drugs;Imprisonment;improved;Individual;Intervention;Interview;Jail;Knowledge;Legal;Legal system;Life;longitudinal database;Medical;medication for opioid use disorder;Mentorship;Methadone;Methods;Morbidity - disease rate;mortality;National Institute of Drug Abuse;novel;Opioid;opioid use;opioid use disorder;Outcome;Overdose;Overdose reduction;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Policies;Population;Postdoctoral Fellow;preference;Prisons;programs;Proliferating;Provider;Public Health;Qualitative Research;Race;Recovery;recruit;Reduce health disparities;Research;Research Personnel;Research Support;Retrospective cohort;Rhode Island;Risk;scale up;Science;Shapes;social;Social Environment;social stigma;sociodemographics;Statistical Methods;structural determinants;substance use;System;Time;Training;Treatment outcome;Treatment Protocols;trend;United States National Institutes of Health;Universities;uptake;Withdrawal

PROJECT_TITLE: A mixed-methods study of predictors and outcomes of methadone and buprenorphine receipt during incarceration


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Early innate immune responses in airway epithelia, including the type I interferon response, are a critical, first- line defense against the diverse milieu of respiratory viruses humans encounter in their environment. Mathematical models of this response hint at specialized responses to interferon in individual airway cell types. Through the development and application of a novel technology platform, this project will experimentally define mechanisms of cellular defenses against influenza virus in the airway in individual cell types, highlighting novel targets for influenza therapy and intervention.

PI_NAMEs: PANKOW, ALEC P (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 2019-nCoV;Acute;Air;Airway Disease;airway epithelium;Anti-viral Agents;Anti-viral Response;Asthma;Automobile Driving;Basal Cell;Biology;cell immortalization;Cell Line;cell type;Cells;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Common Cold;Coronavirus;CRISPR interference;CRISPR-mediated transcriptional activation;Cystic Fibrosis;cytokine;Data;Development;Engineering;Environment;Epithelial Cells;Epithelium;Equilibrium;Escalator;Foundations;functional genomics;Gene Combinations;Gene Expression;Gene Expression Profile;gene function;gene regulatory network;Genes;Genetic;genetic manipulation;Genetic Transcription;Genome engineering;Genomic approach;genomic data;Genomics;Goals;Heterogeneity;high dimensionality;Homeostasis;Host Defense;Human;Hydrogels;Immune;Immunofluorescence Microscopy;Immunologics;Individual;Infection;Influenza;Influenza A virus;influenzavirus;Injury;Innate Immune Response;Intercellular Junctions;Interferon alpha;Interferon Type I;Interferons;Intervention;knock-down;Learning;Life Cycle Stages;Liquid substance;Lower respiratory tract structure;mathematical model;Measures;Mediating;member;Modeling;Molecular Virology;Mucins;Natural Immunity;new technology;non-smoker;novel;pathogen;Pattern;Permeability;Physical Function;physical property;Physiological;Play;Population;predictive modeling;programs;promoter;Property;receptor;Research;Research Personnel;Resolution;Respiration;respiratory infection virus;respiratory pathogen;respiratory virus;response;Rhinovirus;Role;Secretory Cell;Signal Transduction;single-cell RNA sequencing;STAT1 gene;stem cell differentiation;stem cells;Surface;synergism;System;Technical Expertise;Technology;technology platform;Testing;tissue regeneration;Training;training opportunity;transcription factor;Viral;Virus;Virus Replication;Viscosity;Work

PROJECT_TITLE: The innate antiviral response in airway epithelium: a cell type-resolved, functional genomics approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Fragile X Syndrome;Genetics;Heart Disease;Intellectual and Developmental Disabilities (IDD);Pediatric;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Proteins that are involved in RNA-processing are emerging as interesting therapeutic candidates to treat cardiovascular diseases. This project will investigate of one of these proteins (FXR1) and its roles in heart development and physiology. Determining the translational regulation activity and protein-protein interactions of FXR1 and its striated muscle specific forms will unveil the mechanisms regulating gene expression in health and diseases.

PI_NAMEs: BAIS, GABRIELLE  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Actins;Adult;Alternative Splicing;autism spectrum disorder;autosome;Biology;Birth;blood pump;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiovascular Diseases;cardiovascular disorder therapy;Cardiovascular system;Cell Nucleus;Cells;Code;Contracts;CRISPR/Cas technology;Cultured Cells;Cytoplasm;Cytoskeleton;defined contribution;Dependence;Development;Disease;Echocardiography;Endoplasmic Reticulum;Exclusion;Exhibits;Exons;experience;Fellowship;Fetal Tissues;Filament;FMR1 gene;Fragile X Syndrome;FXR1 gene;FXR2 gene;Gene Expression;Genes;Genetic Transcription;Health;Heart;Heart failure;heart function;Homologous Gene;Hypertrophy;in vivo;Individual;Inherited;insight;intercalation;Kinesin;Link;Maintenance;Mass Spectrum Analysis;Measures;mechanical force;mechanical signal;mechanical stimulus;Mechanics;mechanotransduction;Mediating;member;messenger ribonucleoprotein;Messenger RNA;Microtubule Polymerization;Microtubules;Modeling;Morphology;mouse model;multidisciplinary;Multiminicore disease;Mus;Muscle;Muscle Cells;Muscle Fibers;Mutation;Myocardium;Myosin ATPase;Nature;Neuromuscular conditions;Neurons;North Carolina;novel;Nuclear;Oxygen;Periodicity;Physiology;polarized cell;postnatal;pressure;Production;programs;Protein Family;protein function;Protein Isoforms;protein protein interaction;Proteins;Quantitative Microscopy;Regulation;Research;Research Personnel;response;ribosome profiling;Ribosomes;RNA;RNA Binding;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;Sarcomeres;Signal Pathway;Signal Transduction;Skeletal Muscle;Stimulus;Stretching;Striated Muscles;Synapses;System;Tail;Testing;therapeutic candidate;therapy development;Tissues;Training;Transcript;Translating;Translational Regulation;Translations;transmission process;Universities;Western Blotting;Wild Type Mouse

PROJECT_TITLE: The roles of Fragile-X related protein 1 in cardiomyocyte and heart biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Stroke

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE/LAY SUMMARY Stroke is one of the leading causes of disability in the United States with an annual incidence of 800,000, leaving many of these individuals with long-term motor deficits due to motor network damage, limiting their quality of life. This proposal aims to use stereoelectroencephalography based neurofeedback to simulate a damaged network and test the ability of the motor network to learn new motor patterns to overcome this damage. The results from this project will be impactful as they aim to uncover the fundamental nature of motor network adaptation and provide direct supporting evidence for stereoelectroencephalography neurofeedback as a new tool in post-stroke rehabilitation.

PI_NAMEs: JENSEN, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Area;Behavior;Brain;brain based;brain computer interface;Brain region;Bypass;Categories;Clinical;Cues;Custom;Data;design;disability;Electric Stimulation;Electrodes;Epilepsy;Feedback;Goals;Human;Imagery;Incidence;Individual;Learning;Logic;Measures;Methods;Modeling;Monitor;Motor;motor deficit;Movement;Nature;neurofeedback;novel;Patient Monitoring;Patients;Pattern;Physiologic pulse;post stroke;Quality of life;Records;Rehabilitation therapy;response;Rest;screening;Spinal Cord;Stroke;stroke rehabilitation;temporal measurement;Testing;tool;Training;United States

PROJECT_TITLE: Quantifying the Interdependence of the Motor Network Using Intracranial Electrodes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: Project Narrative: Bacteriophage defense systems have been pivotal in the discovery of genetic tools and vital for effective phage therapeutics. Within a few years there has been a vast amount of new phage defense systems discovered however most of the mechanisms of defense are not well understood. Our preliminary results will uncover the mechanism for two undescribed phage defense systems.

PI_NAMEs: GOMEZ, JASPER  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Active Sites;antimicrobial;Bacteria;Bacterial Infections;Bacteriophages;Biochemical;Biological;Biological Assay;Biological Process;Biology;catalyst;Cells;Cholera;Clustered Regularly Interspaced Short Palindromic Repeats;Cosmids;Cytolysis;Defense Mechanisms;Deletion Mutagenesis;Deoxyribonucleases;Development;DNA;DNA Footprint;DNA Restriction-Modification Enzymes;Dyes;Ecology;Elements;Enterobacteria phage T2;Escape Mutant;Escherichia coli;Escherichia coli Infections;Evolution;Exhibits;experimental study;flexibility;Genes;Genetic;Genome;Genomic Library;Horizontal Gene Transfer;host microbiota;Human;human disease;Individual;Infection;interest;Libraries;Link;Lytic;Mediating;Mobile Genetic Elements;Modification;Molecular;Multi-Drug Resistance;Mutagenesis;novel;overexpression;pathogenic bacteria;Population;Predatory Behavior;Predisposition;prevent;promoter;Proton-Motive Force;Research;Resistance;Role;Site;Site-Directed Mutagenesis;Source;System;Testing;Therapeutic;tool;Vibrio;Vibrio cholerae;Vibrio cholerae infection

PROJECT_TITLE: Discovery of new phage defense systems in Vibrio cholerae

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative The International Conference on Gram-Positive Pathogens (ICGPP) provides a forum where investigators studying multiple aspects of gram-positive pathogenesis and biology can interact and share ideas to enhance general understanding of these important pathogens. These interactions will foster new ideas and collaborations to ultimately develop novel therapeutics to treat these sometimes devastating infections.

PI_NAMEs: BOSE, JEFFREY LEE (contact)

PROGRAM_OFFICER_NAME: MULACH, BARBARA L

PROJECT_TERMS: Adult;Agreement;Anabolism;Antibiotic Resistance;Antibiotic-Associated Colitis;Antibiotics;Award;Bacteria;Bacterial Antibiotic Resistance;Biological Process;Biology;career;Cell Communication;Cell Wall;Cells;Cellular biology;Clostridium difficile;Collaborations;Communities;COVID-19 pandemic;Data;Enterocolitis;Epidemiology;Faculty;Fees;Fostering;Funding;graduate student;Gram-Negative Bacteria;Gram-Positive Bacteria;Grant;Health care facility;Hospitals;Individual;Infection;Infectious Skin Diseases;Institution;interest;International;Knowledge;London;Medical;Medical center;meetings;Membrane;methicillin resistant Staphylococcus aureus;microorganism;mortality;Nebraska;Necrotizing fasciitis;novel therapeutics;Oral;Organism;Participant;pathogen;Pathogenesis;Postdoctoral Fellow;posters;Principal Investigator;professor;Prokaryotic Cells;Protein Secretion;Proteins;Protocols documentation;Research;Research Personnel;Schools;Science;Scientist;Senior Scientist;Soft Tissue Infections;stem;supportive environment;symposium;Travel;undergraduate student;United States;United States National Institutes of Health;Universities;Wisconsin

PROJECT_TITLE: 2024 International Conference on Gram Positive Pathogens

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 CAB-D (M1)]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

PHR: PROJECT NARRATIVE Few immunocompetent animals exist to study the dysfunctional immune response in persistent hepatitis C virus (HCV) infection, which affects nearly 58 million people and is a significant contributor to liver disease and hepatocellular carcinoma worldwide. Norway rat hepacivirus (NrHV) is a close relative of HCV that can recapitulate the liver pathology and other relevant characteristics of HCV infection in immunocompetent mice, thus serving as a physiologically relevant and promising surrogate model for studying the immune response to chronic HCV infection. The results of this study will provide an in-depth longitudinal characterization of the immune response to chronic NrHV infection, uncovering the immunological mechanisms that drive immune dysfunction, as well as the cellular phenotypes associated with chronic viral hepatitis.

PI_NAMEs: BOBROWSKI, TESIA  (contact)

PROGRAM_OFFICER_NAME: MORABITO, KAITLYN MELISSA

PROJECT_TERMS: Affect;age related;Animal Model;Animals;Anti-viral Agents;Antigen-Antibody Complex;antigen-specific T cells;Antigens;Atlases;CD8B1 gene;Cell Lineage;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Chronic;Chronic Hepatitis C;chronic infection;Chronic viral hepatitis;Complex;Data;Development;Disease;drug clearance;end stage liver disease;Environment;Evolution;exhaust;exhaustion;Foundations;Functional disorder;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Growth;Health;Hepatic;Hepatitis C;Hepatitis C virus;Hepatitis C-Like Viruses;Human;Immune;immune cell infiltrate;Immune response;Immune System Diseases;Immunocompetent;Immunologic Techniques;Immunologics;immunoregulation;Infection;Inflammation;Investigation;Knowledge;Liver;Liver diseases;liver infection;Lymphocytic choriomeningitis virus;Maintenance;Malignant neoplasm of liver;Mentorship;Modeling;Molecular;mouse model;multiple omics;Mus;Nature;network models;novel;Pathology;Patients;Peptides;Persons;Phenotype;Physiological;Play;Predisposition;prevent;Preventive vaccine;Primary carcinoma of the liver cells;programs;Rattus;Rattus norvegicus;Research;Resolution;response;Risk;Risk Factors;Role;Scientist;single-cell RNA sequencing;Specificity;Study models;T cell receptor repertoire sequencing;T cell response;T-Cell Immunologic Specificity;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Time;training opportunity;transcription regulatory network;transcriptomics;tumor-immune system interactions;Viral;Viral Antigens;viral liver disease;Viral Pathogenesis;Virus;Virus Diseases;Work

PROJECT_TITLE: Defining Immune Dysfunction in Chronic Hepacivirus Infection at Single Cell Resolution


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Immunotherapy;Microbiome

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE We propose to restore the balance of M1/M2 macrophages in peri-implantitis and create an anti-inflammatory environment by inducing M2 polarization using immunomodulatory therapy. This study will provide critical mechanistic data about the pathogenesis of peri-implantitis and the protective role of chemokine CCL2.

PI_NAMEs: CHO, YEJIN  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Affect;Alveolar Bone Loss;Anti-Inflammatory Agents;Antiinflammatory Effect;Bacteria;beta diversity;Biological Assay;Bone Resorption;Cell Communication;Cells;chemokine;cytokine;Data;Debridement;Dental Implants;differential expression;Disease;dysbiosis;Edentulous Mouth;effective therapy;Equilibrium;feasibility testing;Flow Cytometry;gamma-Chemokines;Gene Expression Profiling;Genes;Gingiva;Goals;Graph;Homeostasis;host microbiome;host-microbe interactions;Immune;Immune response;immunomodulatory strategy;immunomodulatory therapies;immunoregulation;Implant;Individual;Infiltration;Inflammation;Inflammatory;inflammatory bone loss;inflammatory milieu;Inflammatory Response;insight;Interleukin-10;Interleukin-4;Ligands;Ligature;Light;Literature;Macrophage;Microbe;microbial;microbial community;microbiome;microbiome composition;microbiota;microCT;Modality;Modeling;Molecular;Mus;neutrophil;novel;Operative Surgical Procedures;Oral;Pain;particle;Pathogenesis;Pathogenicity;Pathway Analysis;Pathway interactions;Patients;peri-implant bone loss;peri-implantitis;Periodontitis;Persons;Phenotype;Play;polarized cell;prevent;Preventive therapy;Psychological reinforcement;Reporting;Resolution;Role;single-cell RNA sequencing;Site;soft tissue;standard care;Surface;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;Time;Tissues;Tooth structure;United States

PROJECT_TITLE: Local Delivery of CCL2 to Reverse Peri-implant Bone Loss in Murine Peri-implantitis

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Endocrine Disruptors;Health Effects of Indoor Air Pollution;Liver Disease;Microbiome;Nutrition;Pediatric;Prevention

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Metabolic-associated fatty liver disease (MAFLD) is a significant public health issue worldwide, and has traditionally been linked to nutritional imbalances, such as a western diet. Early life exposure to legacy and current-use flame retardants, namely polybrominated diphenyl ethers (PBDEs) and tetrabromobisphenol A (TBBPA) lead to inflammation and metabolic disorders, and they are increasingly recognized as environmental contributors of MAFLD. My research will determine how the interactions between early life PBDE or TBBPA exposure and an obesogenic diet later in life modulate the gut-liver axis and MAFLD risk in a novel quadruple human transgenic mouse model, and this will lay the foundation for developing novel therapeutic strategies to mitigate MAFLD in susceptible pediatric populations.

PI_NAMEs: LIM, JONGPYO JOE (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Adult;Animals;carbohydrate metabolism;cell type;Cells;Childhood;Childhood Injury;chromatin immunoprecipitation;Complex;constitutive androstane receptor;CYP3A4 gene;cytokine;Development;Diet;Disease;disorder risk;Dose;dysbiosis;early life exposure;Environment;environmental stressor;Epidemiology;Exposure to;fatty liver disease;Feces;Fellowship;Flame Retardants;Foundations;Genes;Germ-Free;gut microbiome;gut microbiota;gut-liver axis;Heavy Drinking;Hepatocyte;Human;Human Milk;humanized mouse;immune cell infiltrate;Immunologics;Inflammation;Inflammatory;Intestines;Knowledge;Large Intestine;Lead;Life;Link;lipid metabolism;Liver;Liver diseases;liver injury;Metabolic;Metabolic Diseases;metabolic phenotype;metabolic-associated fatty liver disease;metabolomics;Metagenomics;microbial;microbial composition;microbiota transplantation;Molecular;mouse model;Mus;neonatal exposure;neonate;novel;novel therapeutic intervention;Nuclear Receptors;Nutritional;obesogenic;Orthologous Gene;Outcome;Oxidative Stress;Pathogenesis;Pathway interactions;Placenta;polybrominated diphenyl ether;Population;postnatal;Predisposition;Pregnancy;pregnane X receptor;Prevalence;programs;Public Health;pup;Receptor Signaling;Research;Resolution;Risk;Risk Factors;Shotgun Sequencing;single-cell RNA sequencing;Testing;tetrabromobisphenol A;Tight Junctions;Time;Tissues;Toxic effect;Toxicant exposure;Transcript;Transgenic Mice;Transplantation;Weaning;western diet;Work;Xenobiotic Metabolism;Xenobiotics;young adult

PROJECT_TITLE: Late onset of metabolic liver disease from early life flame retardant exposure and adulthood western diet

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


NIH_SPENDING_CATS: Lung;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE My focus concerns plasticity in the neural system controlling breathing, specifically phrenic long-term facilitation (pLTF) following acute intermittent hypoxia (AIH). I propose to uncover mechanism(s) of heightened pLTF when comparing acute intermittent hypercapnic-hypoxia (AIHH) versus AIH without hypercapnia by testing the hypothesis that AIHH enhances plasticity by optimizing the balance between competing pathways to phrenic motor facilitation. Pursuing this research will train me in new methods and ways of thinking, advance our understanding of respiratory motor plasticity, and may impact clinical trial design since AIH is being explored as a treatment to improve respiratory and non-respiratory motor function in people with spinal cord injuries and ALS.

PI_NAMEs: BUTENAS, ALEC LLOYD EDWARD (contact)

PROJECT_TERMS: Acute;Adenosine;Anesthesia procedures;arm;Behavior;Blood flow;Blood gas;Brain Stem;Breathing;career;Carotid Body;Cell Nucleus;Chemoreceptors;Clinical Treatment;Clinical Trials Design;Data;Denervation;Drops;Equilibrium;Exhibits;experience;Exposure to;Fellowship;Future;Goals;Hand functions;Hour;Human;Hypercapnia;Hypoxia;Hypoxia Pathway;improved;Individual;Induced Neurons;insight;Investigation;knock-down;Knowledge;Maintenance;Methods;Monitor;Motor;Motor Neurons;Motor output;Muscle;neural;Neurobiology;neuromuscular rehabilitation;Neurons;Oxygen;Paralysed;Pathway interactions;Persons;Population;Preparation;prevent;Productivity;Property;Protocols documentation;Proxy;Rattus;receptor;Receptor Activation;Recovery;Research;respiratory;Respiratory Diaphragm;Respiratory physiology;Science;Secure;Serotonin;skills;Spinal;Spinal cord injury;Structure of phrenic nerve;Study models;System;Testing;Therapeutic;Thinking;Tissues;Training;Translation Process;ventilation;Walking

PROJECT_TITLE: Cellular Mechanisms of Acute-Intermittent Hypercapnic-Hypoxia Induced Phrenic Motor Plasticity


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Neurosciences;Nutrition

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative This project aims to identify and quantify neuropeptides expressed in tissue through development of optimized computational software, the results of which will improve our understanding of the specific roles and functions of neuropeptides within the neuroendocrine system involved in the regulation of feeding behavior via the simple crustacean model system, widely recognized as the premier model for these investigations. This research will not only identify key neuropeptides implicated in the feeding process, but will also achieve high-throughput and accurate quantitation of neuropeptide abundance changes through application of an isobaric tagging strategy. The functional and quantitative knowledge gained through completion of this project will enable the discovery of novel neuropeptide biomarkers associated with feeding-related disorders, such as obesity and malnutrition.

PI_NAMEs: FIELDS, LAUREN  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Address;Algorithms;Animals;Anorexia;arginylphenylalaninamide;Behavior;Behavioral;bioinformatics tool;Biological Markers;Biological Models;biomarker discovery;Bulimia;Cancer borealis;Collaborations;Complex;Computer software;computerized data processing;computing resources;Coupling;Crabs;Crustacea;Data;Data Analyses;design;Detection;Development;Disease;Employment;experimental study;Family;feeding;Feeding behaviors;Fingerprint;Food;Health;Homeostasis;Hour;Human;improved;in vivo;Infrastructure;Investigation;Ions;Knowledge;Label;Letters;Libraries;Malnutrition;mass spectrometer;Mass Spectrum Analysis;Mastication;Mediating;Methods;model organism;Modeling;Motor;Names;Nature;Nervous System;Nervous System Physiology;neural circuit;Neurons;Neuropeptides;Neurosecretory Systems;novel;Obesity;particle;Pathway interactions;Pattern;Pennsylvania;Process;protein aminoacid sequence;Protein Analysis;Protein Engineering;Proteins;Regulation;Reproducibility;Research;Resolution;Resources;response;Role;Sampling;Scientist;Sequence Homologs;Signal Transduction;Signaling Molecule;software development;stem;Stomach;Structure;System;Tachykinin;Technology;temporal measurement;Time;Tissue Extracts;Tissues;tool;Translating;trend;Universities;Workload

PROJECT_TITLE: Elucidating the Neuropeptidome Implicated in Crustacean Feeding Processes through Multiplexed Data-Independent Acquisition Mass Spectrometry


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE  PLCG2 is a protein expressed in microglia, the resident immune cells of the brain, that has genetic variants that are protective from and risk causing to Alzheimer’s Disease. By understanding how the protective variant exerts its effect, and by understanding the how small molecule manipulation of PLCG2 affects microglia, PLCG2 will be validated as a therapeutic target for the treatment of Alzheimer’s Disease.

PI_NAMEs: BEDFORD, LOGAN  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapeutic;American;Amyloid beta-Protein;Biochemical;Biological;brain cell;Cell membrane;Cells;Cellular biology;Complex;cytokine;design;Development;Diglycerides;Enzymes;experimental study;extracellular;Genes;Genetic study;Genetic Transcription;genetic variant;Goals;Health;human induced pluripotent stem cells;human old age (65+);Hydrolysis;hyperphosphorylated tau;Immune;In Vitro;Inflammatory;Inflammatory Response;insight;Knock-out;Knowledge;Long-Term Potentiation;loss of function;Mass Spectrum Analysis;Measures;Mediating;Membrane;Methods;Microglia;mitochondrial metabolism;Molecular;Neurofibrillary Tangles;new therapeutic target;novel;Outcome;Pathologic;Phagocytosis;pharmacodynamic biomarker;pharmacologic;Pharmacology;Phenotype;Phosphatidylinositol 4,5-Diphosphate;Phosphorylation;PLCG2 gene;preference;programs;Property;protective allele;protective effect;Proteins;receptor;recruit;release of sequestered calcium ion into cytoplasm;Research;response;Risk;risk variant;Role;Scaffolding Protein;Second Messenger Systems;Senile Plaques;Signal Transduction;small molecule;Societies;Surface;Synapses;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;therapy design;tool;TREM2 gene;Tyrosine Phosphorylation;uptake;Validation;Variant;Work

PROJECT_TITLE: Validating PLCG2 as a target for the treatment of Alzheimer's Disease through cell biology and pharmacological tools

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pain Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE The proposed project is relevant to public health as successful completion of these studies will provide the first- ever data on how gender-affirming sex hormone therapy affects experimental and clinical pain in gender minority adults and will lead to foundational insights regarding the role of sex hormones in pain and sensory processing. Ultimately, these findings will have broad impact and have the potential to inform interventions to reduce or potentially prevent chronic pain for gender minority persons. Data from our work will be impactful to clinicians and may better allow them to inform patients about potential pain-related changes that may occur during gender-affirming care with gender-affirming sex hormone therapy.

PI_NAMEs: CHADWICK, ANDREA LYNN (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Adult;Affect;Androgen Antagonists;androgenic;Androgens;Anterior;Anti-androgen Therapy;antinociception;Birth;Brain;care coordination;Central Nervous System;Chronic;Chronic low back pain;chronic pain;Chronic pain syndrome;cingulate cortex;cisgender;clinical pain;Communication;community engaged approach;Cross-Sectional Studies;Data;Development;Estrogens;experience;Fatigue;Feminization;Fibromyalgia;Functional Magnetic Resonance Imaging;Future;Gender;gender affirmation;gender affirming care;gender affirming hormone therapy;gender affirming medical care;gender minority;gender minority community;gender minority group;Gonadal Steroid Hormones;Health;Hormonal;hormone therapy;improved;Incidence;insight;Institute of Medicine (U.S.);Insula of Reil;Intervention;Interview;Knowledge;longitudinal design;Magnetic Resonance Imaging;Measures;Memory;Mental Health;midbrain central gray substance;minority patient;Moods;neuroimaging;Nociception;nonbinary;novel;observational cohort study;Pain;pain inhibition;pain processing;Pain Threshold;Participant;Patients;Persons;physical conditioning;Physiological;Play;Population;pressure;Prevalence;prevent;Progesterone;prospective;Puberty;Public Health;receptor;Reporting;Research;Rest;Role;Sensory;Severities;sex;sex assigned;Signal Transduction;Sleep;Structure;Symptoms;Syndrome;Tension Headache;Testing;Testosterone;transgender men;transgender women;United States National Institutes of Health;Well in self;women versus men;Work

PROJECT_TITLE: The Impact of Gender Affirming Hormone Therapy on Pain in Gender Minority Adults

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Cholesterol levels in animal cells are controlled by the feedback regulation of the Scap-SREBP pathway, where Scap maintains cholesterol levels by tuning cholesterol synthesis and uptake. The proposed research will identify the structural and biophysical role of cholesterol’s influence on Scap and uncover the molecular mechanism of feedback regulation of the Scap-SREBP pathway. Identifying the underlying mechanisms of how cholesterol accumulates despite the Scap-SREBP pathway would advance strategies to regulate cholesterol synthesis and prevent the onset of cardiovascular diseases.

PI_NAMEs: WILLIAMS, BLAKE CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Animals;Atherosclerosis;Binding;Binding Proteins;Biochemistry;Biological Assay;biophysical analysis;Biophysical Process;Biophysics;Cardiovascular Diseases;cell growth regulation;Cell membrane;Cells;Cellular biology;Cholesterol;cholesterol control;Collection;Complex;Cryoelectron Microscopy;Detergents;Drops;Endoplasmic Reticulum;experimental study;fatty liver disease;Feedback;Fluorescence Resonance Energy Transfer;Goals;Golgi Apparatus;human disease;In Vitro;Integral Membrane Protein;Investigation;Knowledge;Label;Lipid Bilayers;Measures;member;Membrane;Membrane Proteins;Micelles;Modeling;Molecular;Molecular Conformation;Monitor;Movement;Mutagenesis;Names;nanodisk;Nature;Pathway interactions;Play;prevent;protein activation;protein transport;Proteins;reconstitution;reconstruction;Regulation;Regulatory Element;Research;Research Personnel;Research Proposals;Resolution;Resources;response;Role;Rotation;single molecule;single-molecule FRET;skills;Speed;Sterols;structural biology;Structure;System;Techniques;Testing;training opportunity;transcription factor;Transmembrane Domain;Travel;uptake;Work

PROJECT_TITLE: Structural and biophysical investigation of Scap regulation by cholesterol

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04B-S (20)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: NARRATIVE Cardiovascular diseases including arrhythmias, heart failure, stroke and hypertension are prevalent causes of death in the United States and developed world. We propose to hold an interdisciplinary conference to bring together internationally renowned experimentalists and computational modelers in the cardiovascular research field. The goal is to achieve quantitative in-depth understanding of the molecular and cellular mechanisms that cause heart and blood vessel diseases. Understanding the disease mechanisms is critically important for developing new therapeutic strategies to effectively treat cardiovascular diseases. 1

PI_NAMEs: BERS, DONALD M;GRANDI, ELEONORA  (contact);NAVEDO, MANUEL F

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Area;Arrhythmia;Biophysics;Black race;Blood Vessels;Cardiac;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;career networking;Cause of Death;Cell Communication;Cells;Collaborations;Communication;Communities;Complex;complex biological systems;Computer Models;Consensus;Coupling;Data;data integration;Databases;design;Disabled Persons;Disease;dynamic system;effective therapy;Evaluation;Experimental Models;experimental study;Feedback;Female;Formulation;Functional disorder;Gifts;Goals;Grant;Health;Heart;Heart Diseases;Heart failure;Hypertension;Incentives;Individual;interdisciplinary collaboration;Interdisciplinary Study;International;Investigation;Ion Channel;Journals;Knowledge;Latin America;mathematical model;Mathematics;meetings;Minority;Minority Groups;Minority Participation;Mission;Modeling;Molecular;Muscle function;National Heart, Lung, and Blood Institute;Nature;Nonlinear Dynamics;novel therapeutic intervention;Oral;Organ;Outcome;Paper;Participant;Persons;Physicians;Physiology;posters;programs;Property;Publications;Publishing;Regulation;Research;Research Personnel;Scientist;Series;Side;Signal Transduction;Smooth Muscle Myocytes;social media;Societies;Stroke;Study models;success;symposium;System;Time;Tissues;tool;Underrepresented Populations;United States;Vascular Diseases;Vascular Smooth Muscle;Vasospasm;web site;Woman;Work

PROJECT_TITLE: Systems Approach to Understanding Cardiovascular Disease - Ion channels, Ca2+ regulation and signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M4)]


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Methamphetamine;Neurosciences;Rare Diseases;Stimulant Use and Misuse;Substance Misuse

PHR: Project Narrative Nonmuscle Myosin IIB (NMIIB) is an ATPase motor protein that generates force on actin filaments to serve as an essential driver of the actin cytoskeleton’s re-organization during synaptic plasticity. NMIIB activity is necessary for this spine structural plasticity that contributes to learning and memory storage, yet it is poorly understood. The development of a knock-in, endogenously tagged NMIIB mouse line will allow for super resolution microscopy studies to uncover the localization of NMIIB throughout the neuron at rest and during neuronal stimulation and then to measure the subcellar dynamics of NMIIB during stimulation and visualize the effect of NMIIB activity on actin dynamics.

PI_NAMEs: REED, SHAYNA JORDAN (contact)

PROJECT_TERMS: Actins;Address;Affinity Chromatography;Amygdaloid structure;Area;ATP phosphohydrolase;Behavior;Biochemical;Biological;Biology;Brain;Brain region;Cell Proliferation;Cells;Chemosensitization;Clinic;Collaborations;Complex;Cytokinesis;Cytoskeletal Modeling;Cytoskeleton;Data;Dendritic Spines;Development;Disease;Equilibrium;excitatory neuron;experimental study;F-Actin;Filament;Foundations;functional plasticity;Generations;genetic manipulation;Glioblastoma;Glioma;Hippocampus;Image;imaging modality;Information Storage;interest;Knock-in;Knock-in Mouse;Learning;Link;Location;Maintenance;Measurement;Measures;Mediating;Mediator;Memory;Methamphetamine;methamphetamine exposure;Methamphetamine use disorder;Microfilaments;microscopic imaging;Microscopy;Molecular;Molecular Conformation;molecular dynamics;Motility;Motivation;Motor;Motor Activity;mouse model;Movement;Mus;Myosin ATPase;N-Methyl-D-Aspartate Receptors;neoplastic cell;neural network;Neurobiology;Neurons;non-muscle myosin;Nonmuscle Myosin Type IIB;novel;Optics;particle;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phosphorylation;polymerization;Polymers;Population;postsynaptic;prevent;Process;Program Development;protein complex;Proteins;Publishing;Receptor Activation;reconstruction;Regulation;response;Rest;Rodent;Role;Sampling;Signal Pathway;Signal Transduction;single molecule;small molecule;Spinal;Stimulus;Structure;superresolution imaging;superresolution microscopy;Synapses;Synaptic plasticity;Testing;Therapeutic;therapeutic target;tool;trafficking;tumor microenvironment;ultra high resolution;Vertebral column;Visualization;Work

PROJECT_TITLE: Exploring synaptic actin-myosin dynamics with super resolution microscopy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: PHILADELPHIA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Aging-related disorders, including Parkinson's Disease, Alzheimer's Disease and related dementias (ADRDs), affect over 8 million people in the US, and present a significant challenge to traditional, structure0based drug discovery methods due to the shape shifting nature of the aggregating proteins in these diseases. The proposed research aims to develop a new assay for determining fibril morphologies (FMs) in these diseases, addressing the variability in current in vitro assays critical for understanding compound binding and cellular toxicity. This advancement will facilitate the creation of a comprehensive FM library, enhancing reproducibility and accelerating progress in ADRD research through high-throughput screening and machine learning techniques.

PI_NAMEs: PEREZ, RYANN MICHAEL (contact)

PROJECT_TERMS: Acceleration;Acetylation;Address;Adopted;Affect;Affinity;aging related;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Amyloid Fibrils;Amyloidosis;Area;Atomic Force Microscopy;beta pleated sheet;Binding;Biological Assay;Biology;Biophysics;Buffers;Chemicals;Chemistry;Communities;Concentration measurement;cost effective;Cryoelectron Microscopy;Custom;Cysteine;Data;Data Set;Dementia;Dementia with Lewy Bodies;density;Deposition;design;Digestion;Disease;drug discovery;Ensure;Enzymes;experience;Future;Goals;high throughput screening;imaging agent;in vitro Assay;in vivo;Infrastructure;ionization;Kinetics;Knowledge;Language;Lead;Lewy Bodies;Libraries;Literature;Machine Learning;machine learning model;machine learning prediction;MALDI-TOF Mass Spectrometry;Maps;Measures;Medicine;Methods;Modification;Molecular Conformation;Monitor;monomer;Morphology;Multiple System Atrophy;Mutation;Names;Nature;Nervous System Disorder;Neurons;Parkinson Disease;Parkinson's Dementia;Pathologic;Patients;Pennsylvania;Peptide Fragments;Peptide Hydrolases;Peptides;Persons;Phosphorylation;Positioning Attribute;Post-Translational Protein Processing;Preparation;Principal Investigator;Process;protein aggregation;Proteins;Protocols documentation;Pythons;radioligand;Reaction;Reproducibility;Research;Research Proposals;Resources;Sampling;screening;Shapes;Site;small molecule;Sodium Chloride;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;structural biology;Structure;Surface;tau Proteins;Techniques;Therapeutic;time use;Tissue Sample;Tissues;Toxic effect;Tube;Universities;Writing

PROJECT_TITLE: Combining Chemical Biology and Machine Learning to Generate Reproducible Amyloid Fibrils

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04A-V (20)]


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE During B cell development in the bone marrow, rapid transcription at the immunoglobulin loci coding and noncoding segments is essential for the generation of specific antibodies against vast number of antigens. The transcriptional and post transcriptional regulation of the noncoding RNAs generated is important since these ncRNAs not only play an important role in controlling gene expression, genome organization, and DNA rearrangement mechanisms for generating diverse sets of antibodies, but when not controlled properly cause genomic instability and/or B cell immunodeficiency. In this application, we evaluate the role of noncoding RNA expressed from the immunoglobulin loci in developing bone marrow B cells, specifically their role in diversifying the antibody repertoire.

PI_NAMEs: BASU, UTTIYA  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: abl Oncogene;activation-induced cytidine deaminase;adaptive immune response;Affinity;Alleles;Antibodies;Antibody Affinity;Antibody Repertoire;Antigen Receptors;Antigens;Attenuated;Automobile Driving;B-Cell Development;B-Lymphocytes;biochemical tools;Biochemistry;Biology;Bone Marrow;Cell Line;Cell Physiology;Cell Therapy;Chromatin;Code;cofactor;Complex;Coupled;Data;Defect;Disease;Distal;DNA;DNA Double Strand Break;DNA Repair;DNA Single Strand Break;enzyme activity;Enzymes;Epigenetic Process;exosome;experience;Gene Activation;Gene Expression;Gene Rearrangement;Generations;Genes;Genetic Recombination;Genetic Transcription;Genome;genome editing;Genomic Instability;genomic tools;Heavy-Chain Immunoglobulins;helicase;Hematopoietic stem cells;Hereditary Disease;Human;humoral immunity deficiency;Hybrids;IGH@ gene cluster;Immune system;Immune System Diseases;immunodeficiency;Immunoglobulin Class Switching;Immunoglobulin Genes;immunoglobulin light chain locus;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;Immunoglobulins;insight;Laboratories;leukemia/lymphoma;Life;Light;Light-Chain Immunoglobulins;Liquid substance;LoxP-flanked allele;Measures;Mediating;Microscopy;Modeling;Modification;mouse model;Mus;mutant;mutant mouse model;Mutation;Nomenclature;Pathway interactions;Patients;Peptide Signal Sequences;Phase;Phosphotransferases;Play;Post-Transcriptional Regulation;posttranscriptional;Prevention;Process;Property;Proteins;Protocols documentation;Receptor Gene;Regulation;repaired;Research Design;RNA;RNA Helicase;RNA metabolism;RNA Processing;Role;secondary lymphoid organ;Secondary to;SETX gene;single molecule;Site;SKI gene;SKIV2L gene;Specificity;System;tool;Transcriptional Regulation;Trichohepatoenteric syndrome;Untranslated RNA;V(D)J Recombination;Work

PROJECT_TITLE: RNA associated mechanisms for antigen receptor gene diversification during immature B cell development

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Mental Health;Neurosciences

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE The neuronal transcriptional response to activation enables cognitive processes such as learning and memory. One way that neuronal gene expression can be altered is through the addition or removal of chemical modifiers on histones, proteins that bind and regulate DNA. In this proposal, I will define how crotonylation, a newly identified histone modification, is regulated by neuronal activation, how it influences gene expression during neuronal activation, and how it controls learning and memory.

PI_NAMEs: PETRONGLO, JENNA ROSE (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Acetylation;Acyltransferase;Affect;Antibodies;behavior test;Binding Proteins;Biological Assay;Brain;cell type;Chemical Modifier;Chromatin;Cognition;cognitive process;Collaborations;conditioned fear;Data;Data Set;Deposition;Detection;Development;Developmental Delay Disorders;Disease;DNA;Early Gene Transcriptions;Enzymes;Epigenetic Process;epigenetic regulation;Excision;experience;Family;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic Transcription;Genomics;Goals;Hippocampus;histone modification;Histones;Immediate-Early Genes;Induced Neurons;Injections;Intellectual functioning disability;Laboratories;Learning;Lentivirus;Link;long term memory;Lysine;Maps;Measures;Memory;Mental disorders;Methods;Methylation;Mus;mutant;Mutation;Nervous System Disorder;neural;Neurodevelopmental Disorder;Neurons;novel;novel strategies;object recognition;Phosphorylation;Physiological;Play;Post-Translational Protein Processing;preference;Process;promoter;Proteins;Reaction;Reader;Reagent;Regulation;response;Role;Shapes;Short-Term Memory;Site;spatial memory;Specificity;Stimulus;Structure;Syndrome;System;Testing;Time;tool;Transcriptional Regulation;transcriptome sequencing;Transferase;tris(2-carboxyethyl)phosphine;Ubiquitination;Viral Vector;Work

PROJECT_TITLE: Histone crotonylation as a novel regulator of learning and memory

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


NIH_SPENDING_CATS: Hematology;Orphan Drug;Rare Diseases;Sickle Cell Disease

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Sickle cell disease is an inherited red blood cell disorder characterized by excess inflammation and many severe acute and chronic inflammatory complications. Our lab found that heme, a major inducer of inflammation in patients with sickle cell disease, activates the pro-inflammatory protein caspase-4. To determine the suitability of caspase-4 as a drug target, this project will investigate the mechanism of activation of caspase-4 and characterize how activation of caspase-4 contributes to inflammatory complications of sickle cell disease.

PI_NAMEs: SALGAR, SURUCHI  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Acute;acute chest syndrome;Acute Lung Injury;Adverse effects;Affinity;beta Globin;Binding;Blood;Blood Vessels;Calorimetry;career;CASP1 gene;Caspase;Cell Death;Cells;Chemotaxis;Chronic;chronic pain;cofactor;college;Complication;Core Facility;curative treatments;cytokine;Cytolysis;Data;Development;Disease;Dose;Drug Targeting;druggable target;Endothelial Cells;Endothelium;Environment;Erythrocytes;Event;experience;extracellular;Fellowship;Functional disorder;Future;gene therapy;Genes;Goals;Hematological Disease;Hematologist;Hematology;Hematopoietic Stem Cell Transplantation;Heme;heme receptor;Hemoglobin;hemoglobin polymer;Hemolysis;Homologous Gene;Human;hydroxyurea;Immune;Impairment;Inflammation;Inflammatory;inflammatory marker;Inherited;Injections;insight;Institution;Interleukin-1 beta;intravital microscopy;Knock-in;Knockout Mice;Knowledge;Laboratory Finding;Life;Life Expectancy;Macrophage;Mediating;Medical center;Medicine;Modeling;monocyte;mouse model;Mus;Mutagenesis;mutant;Mutation;Natural Immunity;neutrophil;Pain;Pathway interactions;Patients;Pediatric Hospitals;Persons;prevent;Proteins;Publishing;Quality of life;Reaction;Recombinants;Research;Resource-limited setting;response;Risk;Role;Scientist;Sickle Cell Anemia;Site;small molecule;standard of care;stoichiometry;success;targeted treatment;Testing;Texas;Therapeutic;therapeutic target;Tissues;Titrations;Training;Work

PROJECT_TITLE: Inflammatory Caspase Activation in Sickle Cell Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-B (20)]


NIH_SPENDING_CATS: Autoimmune Disease;Immunotherapy

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  T follicular regulatory cells play a crucial role in preventing self-reactive B cells from inducing potent autoimmunity. However, the ontogeny, stability, and antigen specificity of T follicular regulatory cells remain poorly understood. Further characterizing these fundamental aspects of T follicular regulatory cell biology will allow us to better study their role in maintaining humoral tolerance, likely identifying new functions for these cells.

PI_NAMEs: GRAHAM, TAYLOR  (contact)

PROJECT_TERMS: Ablation;Adopted;Adoption;Adoptive Transfer;Antibody Response;Antigen Presentation;Antigen-Presenting Cells;Antigens;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactive B cell;B-Cell Antigen Receptor;B-Lymphocytes;Biology;CD4 gene;Cell Lineage;Cell Physiology;Cells;Cellular biology;Clonal Deletion;Clone Cells;Data;Dendritic Cells;Development;Excision;Exhibits;FOXP3 gene;Frequencies;Growth;Helper-Inducer T-Lymphocyte;Homeostasis;Human;Immune response;Immunity;Immunization;Immunize;improved;In Vitro;in vivo;Individual;insight;interest;Knowledge;Life Cycle Stages;Literature;Longitudinal Studies;Maintenance;Mediating;Modeling;Mus;Nature;Ontology;Phenotype;Play;Population;prevent;programs;Reaction;Recurrence;Regulation;Regulatory T-Lymphocyte;Reporting;response;restraint;Role;Signal Transduction;single cell sequencing;Site;Specificity;Structure of germinal center of lymph node;T cell receptor repertoire sequencing;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Thymus Gland;Time;Tonsil;Transgenic Organisms;Work

PROJECT_TITLE: Development, stability, and antigen specificity of T follicular regulatory phenotype cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Research findings based on genomic variation occurring in individuals of primarily European ancestry is the foundation for many precision medicine initiatives, and thus results in deficient translation in and inequitable care for individuals of non-European and admixed ancestry. Despite the potential for precision medicine initiatives to be particularly promising for chronic diseases, few genomic studies employ ancestry-informed genomic methods to improve gene discovery and risk prediction efforts for underrepresented groups. The proposed doctoral research will investigate the interactions between genetic variation, genetic ancestry, and known social and structural risk factors in the context of electronic health record data for recently admixed populations of African ancestry, and the proposed postdoctoral research will investigate the ethical, legal, and social implications of integrating ancestry-informed genomics into current genomics-driven precision medicine initiatives.

PI_NAMEs: ELLIS, KIMBERLYN A (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, DAVE J

PROJECT_TERMS: Address;Admixture;Adult;African American population;African ancestry;All of Us Research Program;Asthma;Award;Behavioral;biobank;Bioethics;Biological;career;Caring;Chronic Disease;Clinical;Collaborations;Communities;Complement;Complex;Data;Development;Disease;disease diagnosis;disease phenotype;disorder risk;Disparate;doctoral student;Early Diagnosis;Early Intervention;Electronic Health Record;Environment;Equity;ethical, legal, and social implication;European;European ancestry;experience;Failure;Fostering;Foundations;Funding;Future;gene discovery;Gene Frequency;Genetic;genetic association;Genetic Predisposition to Disease;Genetic Research;Genetic Risk;Genetic study;Genetic Variation;Genomic approach;genomic data;genomic variation;Genomics;Goals;Guidelines;Health;Health Disparities Research;health equity;Health Policy;Heterogeneity;Human;human genomics;improved;Individual;Inequality;Inequity;innovation;Interdisciplinary Study;Joints;Latin American;Medical Informatics;Mentorship;Methods;Minority Groups;Morbidity - disease rate;Motivation;novel;Outcome;Phenotype;Policies;policy implication;Population;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;precision medicine;Precision Medicine Initiative;Predisposition;Prevalence;Race;racial identity;Recommendation;Research;Research Personnel;Research Project Grants;research to practice;Resources;Risk;Risk Factors;risk prediction;Role;Scientist;sex;Sex Differences;social;social factors;social health determinants;Societies;Training;Translations;Underrepresented Populations;United States;Universities

PROJECT_TITLE: Utilization and Assessment of Ancestry- Informed Genomics in Admixed Populations: Recommendations for Precision Medicine Initiatives

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PHR: PROJECT NARRATIVE Non-coding mutations that affect MECP2 expression can have profound consequences for neurodevelopmental health. However, because MECP2 enhancers and repressors have not been fully defined, it has been challenging to interpret the pathogenicity of non-coding variants within or near MECP2. I propose to expand and refine the map of MECP2 enhancers and repressors by testing novel candidate regulatory elements for an effect on MECP2 expression and by interrogating known regulatory elements to find the critical transcription factor binding sites driving their activity.

PI_NAMEs: SCHUMAN, REBECCA MEYER (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Affect;Alleles;autism spectrum disorder;Automobile Driving;Behavioral;Binding;Binding Sites;Bioinformatics;Biological Assay;Biology;Brain;candidate validation;career;Catalogs;Cell Differentiation process;Child;Chromatin;college;CRISPR/Cas technology;Data Set;Defect;Developmental Delay Disorders;Diagnosis;Diagnostic;Disease;disorder risk;Distal;DNA Binding;dosage;Elements;Enhancers;Environment;Female;gain of function;gain of function mutation;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;Genetic Predisposition to Disease;Genetic Transcription;Goals;Health;Heritability;Hormones;Human;human induced pluripotent stem cells;improved;In Vitro;individuals with autism spectrum disorder;Intellectual functioning disability;interest;Language Disorders;Link;loss of function;Luciferases;male;Maps;MeCP2 Duplication Syndrome;Medical center;Medicine;Methyl-CpG-Binding Protein 2;Modeling;Molecular Biology Techniques;molecular phenotype;Mus;Mutation;Nervous System Disorder;Neurodevelopmental Disorder;Neurologic Symptoms;Neurons;novel;Nucleic Acid Regulatory Sequences;Nucleotides;Outcome;Pathogenicity;Phenotype;Positioning Attribute;promoter;protein expression;Proteins;recruit;Regulatory Element;repetitive behavior;Reporter;Research;Rett Syndrome;RNA;Role;Scientist;Seizures;Severities;Sex Bias;Sex Chromosomes;Sex Differences;Sex Ratio;sexual dimorphism;skills;social;social communication impairment;Symptoms;Technical Expertise;Testing;Texas;Training;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Untranslated RNA;Variant;Western Blotting;Work;Writing;X Chromosome

PROJECT_TITLE: Defining critical MECP2 cis-regulatory elements towards identifying genetic candidates for male-biased autism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative Eosinophilic esophagitis (EoE) is an emerging form of allergic inflammation that exerts a significant clinical and financial burden worldwide. Here, we will define the impact of EoE inflammation on mitochondrial biology, as well as the functional significance of mitochondria in EoE. These studies have great potential to advance our understanding of EoE pathobiology, which may then translate to improved clinical care of EoE patients.

PI_NAMEs: JACKSON, JAZMYNE  (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: 3-Dimensional;Allergic inflammation;Biogenesis;Biology;career;career development;Chronic;Clinical;clinical care;Coupled;Data;Development;Disease;disease model;Eosinophilic Esophagitis;Epithelial Cells;Epithelium;Esophagus;exosome;Fellowship;Financial Hardship;food allergen;Funding;Future;Genetic;genetic manipulation;healing;Human;human subject;IL4 gene;Immune;improved;In Vitro;in vivo;Inflammation;inflammatory milieu;innovation;Interleukin-13;keratinocyte;Mediating;Mediator;Membrane Potentials;Mentors;Mitochondria;Mitochondrial DNA;mitochondrial genome;mitochondrial membrane;Modeling;Molecular;Molecular Biology;mtTF1 transcription factor;Mus;novel;Organoids;Oxidative Stress;Pathogenesis;Pathway interactions;Patients;pharmacologic;pleiotropism;Postdoctoral Fellow;PPAR gamma;Regulation;Research Personnel;Research Proposals;restoration;Role;Signal Transduction;Squamous Differentiation;Squamous Epithelium;STAT6 gene;success;Technical Expertise;Testing;Tissues;Training;Translating;translational impact;translational potential;United States National Institutes of Health

PROJECT_TITLE: Mechanisms and functional role of mitochondria in eosinophilic esophagitis


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics;Infectious Diseases

PHR: PROJECT NARRATIVE  Human cytomegalovirus (HCMV) has two phases of its infectious cycle, lytic and latent infection, that enable lifelong infection in its host. During lytic infection, a virion protein called pp71 traffics to the nucleus and promotes expression of lytic genes, however, during latency it remains in the cytoplasm. I will investigate why it traffics to the nucleus during lytic infection but fails to do so in latent infection.

PI_NAMEs: WISDOM, ESTHER LYNNE (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Biological;Capsid;Cell Differentiation process;Cell membrane;Cell Nucleus;Cells;Chemicals;Complex;Cytomegalovirus;Cytomegalovirus Infections;Cytoplasm;Data;DAXX gene;druggable target;Ectopic Expression;Elements;Endocytosis;Endosomes;Event;experimental study;Fibroblasts;Future;Gene Expression;Genetic Transcription;Genome;Glycoproteins;Herpesviridae;Human;Immediate-Early Genes;Infection;Investigation;latent infection;Lytic;lytic gene expression;Lytic Phase;Mediating;Methods;Monitor;Myeloid Cells;Nuclear;Outcome;Pathway interactions;Phase;Phenotype;Phosphotransferases;Platelet-Derived Growth Factor alpha Receptor;Platelet-Derived Growth Factor Receptor;Production;Productivity;Proteins;receptor;Regulation;Reporting;Role;Testing;trafficking;Trans-Activators;treatment strategy;Undifferentiated;Viral;Viral Genes;Virion

PROJECT_TITLE: Defining the Impact of Entry Pathways on the Outcome of Human Cytomegalovirus Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

PHR: Mitochondria are crucial to the function of mature cardiomyocytes, but their structural and energetic phenotypes remain under-studied in direct cardiac reprogramming. I propose to characterize mitochondria as cardiac fibroblasts are converted to induced cardiomyocyte-like cells in order to better understand reprogramming mechanisms. I will also investigate whether inducing mitochondria to look and behave more like cardiomyocyte mitochondria can improve reprogramming strategies.

PI_NAMEs: SPURLOCK, BRIAN M (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Biological Assay;Calcium;Cardiac;Cardiac Myocytes;Cell Cycle;Cell Reprogramming;Cells;Cellular Morphology;Chimeric Proteins;clinical application;clinical translation;Confocal Microscopy;Data;Development;Early identification;Elements;Equilibrium;Evaluation;Exhibits;experimental study;Fatty Acids;Fibroblasts;fusion gene;Galactose;GATA4 gene;Glycolysis;Heart Injuries;improved;In Vitro;in vivo;Induced Cardiomyocytes;Inner mitochondrial membrane;innovation;insight;Intervention;ischemic injury;knock-down;loss of function;Measures;Membrane Potentials;Metabolic;Mitochondria;Mitochondrial Matrix;Molecular;Morphology;Myocardial Infarction;Myocardial Ischemia;novel;Optic atrophy 1;Patients;Phenotype;Process;Production;Proteins;Protocols documentation;Regulation;Reporting;Respiration;Sarcomeres;small molecule inhibitor;Structure;Structure-Activity Relationship;System;Time;transcriptome sequencing;transdifferentiation;translational approach;Work

PROJECT_TITLE: Studying Mitochondrial Dynamics and Energetics During Cardiac Reprogramming

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (20)]


ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: When the central nervous system is disrupted by injury or neural device implantation, local glial cells deprioritize normal, healthy functions in favor of reactive phenotypes that assist in the resolution of the injury. Saccharide- based materials offer the ability to regulate this glial adaptive reprogramming response both by leveraging natural biofunctionality of the glycans and by controlled presentation of chemical and mechanical stimuli. In this project, I will develop polysaccharide biomaterials to (1) test the ability of inherently bioactive glycans to stimulate glia- based repair following stroke, and (2) establish synthetic glial interfaces that allow for the phenotypic, functional, and transcriptomic characterization of adaptive reprogramming.

PI_NAMEs: DUBOIS, ERIC  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;adeno-associated viral vector;Astrocytes;Biocompatible Materials;Biological Assay;Biology;biomaterial development;calcium indicator;Calcium Signaling;Cell Reprogramming;Cellulose;Central Nervous System;central nervous system injury;Chemicals;Chemistry;Chemotaxis;Chronic;Cues;cytokine;design;Development;Devices;Dissection;Engineering;Environment;extracellular;Foreign Bodies;Gene Expression Profiling;Genetic Transcription;Goals;Hydrogels;Hydrophobicity;Immunohistochemistry;Implant;implantation;improved;in vivo;Injectable;Injections;Injury;innovation;insight;intravital imaging;Ischemic Stroke;Isothiocyanates;Knowledge;Libraries;Longevity;mechanical properties;mechanical signal;mechanical stimulus;Mechanics;Mediating;Microglia;migration;minimally invasive;Modification;Mole the mammal;Molecular;Molecular Sieve Chromatography;monomer;Morphology;mouse model;Nerve Regeneration;neural;neural implant;Neuroglia;Neurons;Neurophysiology - biologic function;Nucleosides;Outcome;Phenotype;physical property;polymerization;Polymers;Polysaccharides;Population;Porosity;Process;Production;programs;Proliferating;Property;rational design;recruit;Regulation;repair function;repaired;Resolution;response;Rheology;Ribosomes;Role;Signal Transduction;Spectroscopy, Fourier Transform Infrared;Speed;Stroke;Surface;Surface Properties;Testing;therapy outcome;Tissues;tool;transcriptomics;Work

PROJECT_TITLE: Glycopolymer Biomaterials for Regulating Adaptive Reprogramming in Glia


ADMINISTERING_IC: ES

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Clinical Research

ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: NARRATIVE – OVERALL CENTER PAH contamination at over 800 Superfund Sites poses a significant exposure risk to humans and the environment. The Oregon State University Superfund Research Program is developing technologies to understand PAH mixture composition at superfund sites, to predict their toxicity, and to reduce their impacts on the environment.

PI_NAMEs: TANGUAY, ROBYN L (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: Address;Aromatic Polycyclic Hydrocarbons;Behavioral;Bioinformatics;Biological;Biological Availability;Biomedical Research;Body Composition;Cardiovascular Diseases;Chemical Exposure;Chemicals;Chemistry;Collaborations;Communities;community engagement;Complex;Complex Mixtures;Data;Data Analyses;data management;Devices;Disease;Disease Outcome;DNA Damage;Environment;Environmental Engineering technology;Environmental Health;Environmental Science;experience;Exposure to;frontier;Funding;Gene Expression;Goals;Grant;hazard;Hazard Models;Health;Health Hazards;Human;improved;In Vitro;in vivo;Individual;innovation;instrumentation;Laboratories;Link;Location;Lung;Lung Diseases;Malignant Neoplasms;Measures;Metabolic;Metabolism;Mission;Modeling;Monitor;Movement;multidisciplinary;new technology;next generation;novel;novel strategies;Oregon;Outcome;oxidation;Pacific Northwest;Parents;Predisposition;programs;Property;Quality of life;Recommendation;remediation;Research;Research Project Grants;Research Support;respiratory;Risk;Risk Assessment;Risk Reduction;Sampling;Science;Scientist;Site;Soil;Specific qualifier value;success;Superfund;superfund site;System;Techniques;Technology;Testing;three dimensional cell culture;Time;Tissues;tool;Toxic effect;Toxicity Tests;Training;transcriptomics;Translational Research;Universities;UV Radiation Exposure;wearable device;Work;wristband;Zebrafish

PROJECT_TITLE: PAHs: New Technologies and Emerging Health Risks


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed work aims to identify the prevalence and multidimensional correlates of atherosclerotic resilience among 4,000 participants (44% White, 45% Black, 10% Hispanic) in the Risk Underlying Rural Areas Longitudinal (RURAL) Cohort Study. In addition to providing key mechanistic insights into the biopsychosocial pathways underlying atherosclerotic resilience in underserved rural communities, this work may aid in understanding the disparities in cardiovascular health among rural communities. These data may then be used to guide the promotion of cardiovascular health and timely initiation of management strategies for the prevention of cardiovascular disease events for rural Americans.

PI_NAMEs: RAZAVI, ALEXANDER C. (contact)

PROGRAM_OFFICER_NAME: PURKISER, KEVIN

PROJECT_TERMS: Address;Age;age group;American;Ankle;attenuation;biopsychosocial;Black Populations;Black race;Blood Pressure;Calcium;Cardiac;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;Categories;Clinical;Coronary;coronary artery calcium;Data;Diet;Dimensions;Disparity;Enrollment;epidemiology study;Equity;Event;experience;Funding;Future;health outcome disparity;Hispanic;Image;improved;indexing;Individual;insight;Knowledge;Life Style;lifestyle factors;Longitudinal cohort study;Measurement;Measures;men;Modeling;mortality;National Heart, Lung, and Blood Institute;Older Population;Outcome;Participant;Pathway interactions;Persons;Phenotype;Physical activity;Population;premature;Prevalence;Prevention strategy;Primary Prevention;prognostic;promote resilience;psychosocial;Psychosocial Factor;Public Health;Public Health Practice;Race;Research;resilience;resilience factor;Risk;Risk Assessment;Risk Factors;Risk Marker;Rural;rural Americans;rural area;Rural Community;Rural Population;rural setting;rural underserved;Sampling;secondary analysis;sex;social health determinants;socioeconomics;Southeastern United States;Techniques;Testing;Thoracic aorta;Time;Urban Community;Woman;women versus men;Work;X-Ray Computed Tomography

PROJECT_TITLE: Multidimensional Correlates of Atherosclerotic Resilience in Rural Communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


NIH_SPENDING_CATS: Lung;Neurosciences

PHR: Acute intermittent hypoxia, or repetitive periods of low oxygen, has shown great promise as a therapeutic in ongoing clinical trials to improve breathing (and non-respiratory) function in individuals with spinal cord injury and amyotrophic lateral sclerosis. The proposed project will investigate whether behavioral and physiological factors stemming from an individual’s biological clock influence the effectiveness of acute intermittent hypoxia in improving breathing function. These studies will provide important new biological insights for the use of acute intermittent hypoxia as a therapeutic strategy in humans.

PI_NAMEs: JONES, AARON ANDREW (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute;Adenosine;Adult;Amyotrophic Lateral Sclerosis;Anesthesia procedures;antagonist;ARNTL gene;Attenuated;Automobile Driving;Behavioral;Biological;Biological Clocks;Brain-Derived Neurotrophic Factor;Breathing;career development;Cell Nucleus;Cervical spinal cord structure;circadian;circadian biology;circadian pacemaker;circadian regulation;Circadian Rhythms;Clinical Trials;Clinical Trials Design;Development;Diurnal Rhythm;Effectiveness;Electroencephalography;Event;Exhibits;experience;experimental study;Genes;Goals;Human;Hypoxia;improved;In Situ Hybridization;Individual;Injections;insight;interdisciplinary approach;Journals;Larynx;Mammals;Measurement;Metabolic;Modality;Molecular;Motor;Motor Neurons;neural;Neuromuscular Diseases;novel;Outcome;Oxygen;Phase;Physiological;Physiology;post-doctoral training;Protocols documentation;Purinergic P1 Receptors;Rattus;Reflex action;Research;Research Technics;respiratory;Respiratory Diaphragm;Respiratory Disease;Rest;Resting Phase;Rodent;Role;Serotonin;Small Interfering RNA;Spinal cord injury;Sprague-Dawley Rats;stem;Study models;System;Testing;Therapeutic;Time;Training;translational potential;virtual;Whole Body Plethysmography;Work

PROJECT_TITLE: Daily and circadian regulation of respiratory plasticity in freely behaving rats

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cardiovascular;Heart Disease;Prevention;Substance Misuse;Substance Misuse Prevention

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Project Narrative This NRSA F30 fellowship will provide an invaluable and comprehensive training opportunity for a future physician scientist as he develops into an emerging leader in cardiovascular research. The proposed studies will investigate the mechanism of Alcohol-related Cardiomyopathy (AC) pathogenesis and focus on the contribution of a proinflammatory mediator TRAF3IP2. Findings from this research may uncover novel therapeutic options for those suffering from AC.

PI_NAMEs: HARRIS, NICHOLAS R (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Acute-Phase Proteins;Adaptor Signaling Protein;Albumins;alcohol abuse therapy;Alcohol consumption;alcohol exposure;alcohol prevention;Alcohols;C-reactive protein;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;career;career development;Catheterization;Cell Size;Cessation of life;chemokine;Chronic;chronic alcohol ingestion;Clinical;Cohort Studies;Collagen;coronary fibrosis;crosslink;cytokine;Cytokine Signaling;Cytoplasm;Data;Deposition;Development;Diet;Dimensions;Disease;Dose;Echocardiography;Ectopic Expression;Ensure;Enzymes;Ethanol;Exposure to;Extracellular Matrix;feeding;Fellowship;Fibrillar Collagen;Fibroblasts;Fibrosis;Functional disorder;Future;Gene Deletion;Genetic Models;Goals;Heart;Heart failure;heart function;Heart Hypertrophy;Heart Injuries;Heavy Drinking;Histologic;Human;Hypertrophy;Impairment;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Injury;interstitial;Ischemia;Knock-out;Knockout Mice;Left;Left ventricular structure;Liquid substance;loss of function;MAP Kinase Gene;MAPK8 gene;Measures;Medicine;Mentors;Modeling;Molecular;mortality;mouse model;Mus;Myocardial;Myocardial dysfunction;Myocarditis;Myofibroblast;National Institute on Alcohol Abuse and Alcoholism;National Research Service Awards;novel;novel therapeutics;Outcome;Outcome Measure;overexpression;Oxidation-Reduction;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathway interactions;Physicians;Physiological;Play;pressure;Prevention strategy;protein expression;Protein-Lysine 6-Oxidase;Proteins;receptor;Reperfusion Therapy;Reporting;Research;Role;Scientist;Signal Transduction;small hairpin RNA;Source;Stains;Stress;stress activated protein kinase;Structure;Testing;therapeutic target;Time;TNF receptor-associated factor 3;Training;training opportunity;transcription factor;Transcription Factor AP-1;Transferrin;Transgenic Organisms;Ventricular;Wild Type Mouse;Work

PROJECT_TITLE: TRAF3IP2 as a Proinflammatory Mediator of Alcohol-related Cardiomyopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: NARRATIVE We seek NIH support for a diverse cohort of graduate students, postdocs, and early career scientists to attend the 2024 Streptococcal Biology Gordon Research Conference (GRC) and a corresponding Gordon Research Seminar (GRS). The GRC/GRS will significantly improve scientific knowledge in all areas of streptococcal and enterococcal disease including diagnosis, epidemiology, pathogenesis, and treatment, by bringing together the most talented and productive researchers in the field and facilitating their interactions with the next generation of scientists and clinicians.

PI_NAMEs: FEDERLE, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: MULACH, BARBARA L

PROJECT_TERMS: 5 year old;Address;Animals;Antibiotic Resistance;antimicrobial;Antimicrobial Resistance;Applications Grants;Area;Bacteria;bacterial genetics;Basic Science;Biology;career;career development;Cellular biology;Cessation of life;Child;Clinical;Clinical Investigator;cohort;Collaborations;Communicable Diseases;Communication;Communities;Data;design;Development;Diagnosis;Discipline;Disease;educational atmosphere;Elderly;Ensure;Enterococcus;Environment;Epidemiology;equity, diversity, and inclusion;Eukaryotic Cell;Event;Fostering;Funding;Genetic;Genomics;Goals;graduate student;Health;Human;Immunologics;Immunology;improved;Infection;Infectious Diseases Research;interdisciplinary approach;Knowledge;Life;Maine;meetings;Meningitis;microbial;microbial community;Mission;mortality;Multi-Drug Resistance;Necrotizing fasciitis;neonate;next generation;Oral;Organism;Participant;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;peer;Pharyngitis;Pneumonia;Postdoctoral Fellow;posters;Productivity;programs;Recurrence;Regulation;Request for Applications;Research;Research Personnel;resistant strain;Rheumatic Heart Disease;Role;Scientist;Sepsis;Streptococcus;Streptococcus Group B;Streptococcus pneumoniae;Streptococcus pyogenes;Students;success;supportive environment;symposium;Talents;Therapeutic;therapeutic development;Time;Toxic Shock Syndrome;trait;Underrepresented Populations;United States;United States National Institutes of Health;Vancomycin Resistance;Vancomycin resistant enterococcus;Virulence;Work

PROJECT_TITLE: 2024 Streptococcal Biology Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 CAB-D (M1)]