NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE:  This work validates and implements a novel imaging approach for quantitative SPECT imaging of alpha particle radiotherapies. Using computational models, physical phantoms and in a first-in-man study in patients for initial feasibility, we validate our extensive pilot data to derive quantitative activity uptake values of low count producing radiotherapies. The proposal will provide the first quantitative assessment of uptake at lesions and in radiosensitive background organs that has great significance for optimizing patient treatment approaches with alpha particle therapies.

PI_NAMEs: JHA, ABHINAV K (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: absorption;Acceleration;Actinium;Address;adverse event monitoring;Alpha Particles;Anatomy;Androgen Antagonists;androgen independent prostate cancer;Biological Markers;Biopsy;bone;cancer cell;Clinical;clinical efficacy;clinical imaging;clinical translation;Clinical Trials;clinically significant;Collaborations;Collimator;Computer Models;conventional therapy;Cytotoxic Chemotherapy;Data;Daughter;DCNU;detector;Disease;Dose;Dose Limiting;drug development;drug efficacy;efficacy evaluation;Engineering;Evaluation;first-in-human;Framework Regions;Gamma Rays;Generations;Goals;Gold;Image;imaging approach;imaging study;improved;improved outcome;individualized medicine;industry partner;innovation;Intestinal Content;Intestines;Isotopes;Joints;Lesion;Measures;men;Methods;Modeling;Modernization;Noise;non-invasive imaging;novel;Organ;Outcome;particle therapy;Patients;Performance;Photons;Physics;Physiology;Prediction of Response to Therapy;Process;Protocols documentation;Quality of life;Radiation;radiation absorbed dose;Radiation Oncology;Radiation therapy;Radiation Tolerance;Radioisotopes;Radiopharmaceuticals;Radium;reconstruction;Regimen;Resistance;Risk;Safety;Scanning;Schedule;Serum;simulation;single photon emission computed tomography;Site;Skeleton;System;Techniques;Therapeutic;therapy outcome;Thorium;Time;treatment planning;Treatment Protocols;tumor;uptake;virtual clinical trial;Work

PROJECT_TITLE: Ultra-Low Count Quantitative SPECT for Alpha-Particle Therapies

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: COLUMBIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: There is a pressing clinical need to develop new strategies to both encourage and accelerate axon  regeneration in the peripheral and central nervous systems; however, we need to understand the  molecular mechanisms underlying promotion of axonal growth to maximize therapeutic benefits and  minimize potential negative effects. This proposal exploits a previously unrecognized mechanism  that limits rates of axon growth by suppressing translation of stored mRNAs, and we will determine  how broadly this mechanism applies to different neural injuries and mechanisms underlying this axon  growth promotion.

PI_NAMEs: TWISS, JEFFERY L (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acceleration;Acute;Address;Adult;Affect;Attenuated;Automobile Driving;Axon;axon growth;axon injury;axon regeneration;Axotomy;Binding;Biological;calreticulin;casein kinase;Cells;Central Nervous System;Chronic;Clinical;clinically relevant;cohort;Communities;Complex;Cytoplasmic Granules;Data;FRAP1 gene;G3BP1 gene;Growth;Growth Associated Protein 43;Hour;Human;Importins;In Vitro;in vivo;Individual;injured;Injury;injury and repair;insight;knock-down;Knowledge;Lesion;Literature;Messenger RNA;Molecular;Motor;mRNA Translation;Natural regeneration;Nerve;nerve injury;Nerve Regeneration;neural repair;neuromechanism;Neurons;Neurosciences;novel therapeutic intervention;overexpression;Pathway interactions;Peptides;Peripheral nerve injury;Peripheral Nerves;Peripheral Nervous System;Permeability;permissiveness;Phosphorylation;Phosphorylation Inhibition;Phosphotransferases;Physiological;Population;programs;protein aggregation;Protein Biosynthesis;Proteins;Publishing;recruit;Regenerative capacity;Regulation;reinnervation;repaired;Reporting;Research;response to injury;RNA;RNA, Messenger, Stored;Role;Sensory;Signal Transduction;Solid;Specificity;Spinal Cord;Spinal cord injury;stress granule;Tertiary Protein Structure;Testing;Therapeutic;Time;Tissues;tool;Translating;Translational Activation;Translations;Viral;Work

PROJECT_TITLE: Role of Stress Granule Protein Aggregation in Axon Regeneration

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Natural Products

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Antibiotic resistance is becoming a significant problem in human health and infections that were once routinely treated are now resistant to our arsenal of clinically-approved antibiotics. Consequently, the need for new antibiotics has never been greater. This project will utilize integrated genomic, bioinformatic and chemical approaches for accessing and developing new antimicrobial agents from a completely new and unstudied resource, the halophilic microorganisms isolated from the hypersaline environment of the Great Salt Lake.

PI_NAMEs: WINTER, JACLYN MARIE (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter baumannii;Age;American;Anti-Bacterial Agents;anti-microbial drug;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Back;Bacteria;Bacterial Infections;Biochemical;Biochemistry;Bioinformatics;Biological;Biomedical Engineering;Cell Physiology;Cessation of life;Chemical Agents;Chemicals;Cities;Clinical;clinically significant;Cluster Analysis;Coculture Techniques;combat;Coupled;Data;Development;Disease;drug discovery;Drug resistance;drug resource;Enterobacter;Enterococcus faecium;Environment;Epigenetic Process;Escherichia coli;ESKAPE pathogens;Essential Genes;Exhibits;FDA approved;Fermentation;Gene Cluster;Genome;Genomics;Health;Health Care Costs;Healthcare;High Pressure Liquid Chromatography;Human;Human Cell Line;Infection;innovation;Investigation;Klebsiella pneumoniae;Left;Libraries;Mass Spectrum Analysis;Methods;Microbe;microbial;microorganism;Mining;Modification;Molecular;Molecular Target;Multi-Drug Resistance;Natural Products;Natural Products Chemistry;Natural Source;Nature;Nosocomial Infections;novel;Oceans;pathogenic bacteria;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Play;pressure;Productivity;Pseudomonas aeruginosa;quorum sensing;Recombinants;Resistance;resistance mechanism;Resources;Role;scaffold;screening;Sea;Seawater;secondary metabolite;Site;small molecule;social;Sodium Chloride;Soil;Source;Staphylococcus aureus;Structure;tool;Toxic effect;Universities;Utah;Water

PROJECT_TITLE: Genomics-Assisted Antibiotic Discovery from Unprecedented Microbes of the Great Salt Lake

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Hepatitis - B;Immunization;Infectious Diseases;Liver Disease;Obesity;Prevention;Vaccine Related

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Vaccines are a major tool to prevent infection, yet many who receive hepatitis B vaccination do not respond and are not protected. The goal of this proposal is to understand the qualities of the T and B cell responses that enable early prediction of who might have a weak vaccine response by focusing on the immune cells relevant to the antibody response, in order to decipher mechanisms that can be addressed with future vaccine strategies.

PI_NAMEs: HERATI, RAMIN  (contact)

PROGRAM_OFFICER_NAME: FLORESE, RUTH HUAB

PROJECT_TERMS: Address;Adjuvant;Adult;Affect;Affinity;aluminum sulfate;Antibodies;Antibody Response;Antigens;B-Lymphocytes;Biological Markers;CD4 Positive T Lymphocytes;Cell Communication;Cells;Characteristics;Chronic;Circulation;Clinical;Clinical Research;Communicable Diseases;COVID-19;Data;Dose;experimental study;FDA approved;Future;Genetic Transcription;global health;Goals;Hepatitis B Surface Antigens;Hepatitis B Vaccination;Hepatitis B Vaccines;Hepatitis B Virus;Human;Immune;Immunity;Immunization;Immunofluorescence Immunologic;Immunoglobulin Class Switching;Immunoglobulin G;Immunology;improved;In Vitro;Individual;Infection prevention;Inflammation;Inflammatory;Influenza vaccination;Interferons;Longitudinal Studies;lymph node biopsy;Lymphoid;Lymphoid Tissue;Measures;Monitor;Morphology;multimodality;novel vaccines;Obesity;Pathway interactions;Persons;Phenotype;Prevalence;prevent;prospective;rational design;Reaction;Recombinants;response;Role;Series;Signal Pathway;Signal Transduction;Structure;Structure of germinal center of lymph node;System;T-Lymphocyte;Testing;Time;TNF gene;tool;Vaccination;Vaccine Design;vaccine immunogenicity;vaccine response;vaccine strategy;vaccine trial;vaccine-induced antibodies;vaccine-induced immunity;Vaccines

PROJECT_TITLE: A systems immunology approach for predicting poor responses to Hepatitis B vaccination

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Acute Myeloid Leukemia (AML) is a devastating hematopoietic malignancy that is fatal for most of the patients who develop this disease. In this proposal, we will develop and analyze comprehensive genomic, epigenomic, and proteomic databases using samples from AML patients, and genetically defined mouse models with common AML initiating events. The long-term goal of this project is to use these datasets to develop effective, mechanistically-driven therapies directed against the initiating mutations of this disease.

PI_NAMEs: LEY, TIMOTHY J. (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;ATAC-seq;Back;bisulfite sequencing;CBFA2T1 gene;CBFbeta-MYH11 fusion protein;Cell model;Cells;ChIP-seq;Cleavage Under Targets and Release Using Nuclease;Clinical Trials Design;Communities;Core-Binding Factor;Data Analyses;Data Set;Databases;Development;Disease;DNA;DNA sequencing;DNMT3a;DNMT3a mutation;DNMT3B gene;embryo cell;engineered stem cells;Epigenetic Process;epigenomics;Event;fitness;Funding;genetic approach;Genetically Engineered Mouse;genomic locus;Genomics;Goals;Growth;HDAC1 gene;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic stem cells;Histones;Human;induced pluripotent stem cell;inhibitor;insight;leukemia initiating cell;Methods;Molecular;mouse model;mutant;Mutation;novel;overexpression;Pathogenesis;Patients;Pharmaceutical Preparations;phosphoproteomics;PML-RARalpha protein;Precision therapeutics;Preleukemia;Process;programs;Protein Isoforms;Proteins;proteogenomics;Proteomics;RUNX1 gene;Sampling;Series;single cell technology;targeted treatment;therapy design;transcriptome sequencing;whole genome;Work

PROJECT_TITLE: Molecular Pathogenesis of Acute Myeloid Leukemia


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Pulmonary arterial hypertension (PAH) is a rare but incurable disease that ultimately leads to death. In the proposed study, we will investigate the role of mitochondrial dysfunction (MD) in 1) impaired pulmonary angiogenesis, 2) pulmonary artery obliteration, and 3) right ventricle (RV) hypertrophy/dysfunction, all critical components of the complex pathogenesis of PAH. We will investigate novel molecular mechanisms involved in the downstream pathogenic effects initiated by MD and test several therapeutic strategies that showed efficient protection in preliminary studies, including an ability to reverse RV hypertrophy, the primary reason for PAH patients’ death.

PI_NAMEs: RAFIKOVA, OLGA  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Anabolism;angiogenesis;Animal Model;Animals;Apoptosis;Attenuated;Basic Science;Binding;Cardiac Myocytes;Cessation of life;Chronic;Clinical Research;Complex;Data;Development;Diabetes Mellitus;Diagnosis;Disease;Down-Regulation;Electron Transport;Etiology;Event;Functional disorder;Homeostasis;Impairment;In Vitro;in vivo;Life;Ligands;lipid metabolism;Lipids;lipoic acid synthase;Lung;lung pressure;Malignant Neoplasms;Mediating;Medical;Messenger RNA;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;mortality;mutant;Mutation;mutation carrier;novel;novel therapeutics;Outcome;Oxidative Phosphorylation;Pathogenesis;Pathogenicity;Patients;pharmacologic;Phenotype;Play;Point Mutation;Pre-Clinical Model;prevent;primary pulmonary hypertension;Proliferating;Proteins;pulmonary arterial hypertension;Pulmonary arterial remodeling;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular cells;pyruvate dehydrogenase;Rattus;Research;Resistance;Respiration;respiratory complex II;Right Ventricular Hypertrophy;Right ventricular structure;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Secondary to;Signal Transduction;Stress;Supplementation;Testing;Therapeutic;Thioctic Acid;Translational Research

PROJECT_TITLE: Mitochondrial dysfunction in pulmonary hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Diabetes;Neurodegenerative;Neurosciences

ORG_CITY: DAYTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WRIGHT STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Changes in the length or location of the axon initial segment in neurons has been implicated in many neurodegenerative conditions including type 2 diabetes. This application will uncover the role of endoplasmic reticulum stress in type 2 diabetes induced AIS shortening and cognitive impairment while training a future physician scientist. Completion of the proposed research will impact public health by providing important fundamental knowledge of the pathophysiology of diabetic encephalopathy that can be used in future studies to develop treatments for the patients living with these conditions.

PI_NAMEs: SHELBY, JENNAE NICOLLE (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Action Potentials;Address;Age;Alzheimer's Disease;Animal Model;Apoptosis;ATF6 gene;Axon;Brain;Calcineurin;career;career development;Caring;Cell Death;Cell Physiology;Cells;Chronic;Cognitive;Cognitive deficits;cognitive performance;comorbidity;Data;Data Analyses;db/db mouse;Dementia;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic rat;Diagnosis;Disease;Electrophysiology (science);Encephalopathies;Endoplasmic Reticulum;endoplasmic reticulum stress;experimental group;Family;flexibility;Functional disorder;Future;Genetic;Goals;Grant;Hippocampus;Hour;Immunofluorescence Immunologic;Impaired cognition;improved;In Vitro;Inflammation;inhibitor;Knowledge;Learning;Length;Link;Location;Mediator;Memory;meter;mild cognitive impairment;Modeling;morris water maze;mouse model;multi-electrode arrays;Mus;National Research Service Awards;Nerve Degeneration;neurobehavioral test;Neurodegenerative Disorders;neuronal excitability;Neurons;new therapeutic target;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Oxidative Stress;Pathway interactions;Patient Care;patient prognosis;Patient Representative;Patients;pharmacologic;Phosphoric Monoester Hydrolases;Physicians;post stroke;Prefrontal Cortex;prevent;protein folding;Proteins;Public Health;Pyruvaldehyde;Rattus;Research;Research Design;response;Risk;Role;Scientist;sensor;Signal Transduction;Small Interfering RNA;Sodium phenylbutyrate;Streptozocin;Structure;Study Skills;Synapses;Synaptic Transmission;targeted treatment;Techniques;Testing;Therapeutic Research;therapeutic target;Training;training opportunity;Transfection;Tunicamycin;Western Blotting;Writing

PROJECT_TITLE: Unfolding the Link Between the Endoplasmic Reticulum, AIS Shortening, and Cognitive Impairment in Type 2 Diabetes


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Cancer

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, LLC

ORG_STATE: TN

PHR: PROJECT NARRATIVE Overexpression of the anti-apoptotic protein MCL-1 frequently occurs in both solid tumors and hematological malignances, which has inspired the use of small-molecule inhibitors of MCL-1 in clinical trials. MCL-1 has two distinct isoforms –– one that localizes to the outer mitochondrial membrane where it performs its canonical anti- apoptotic function and one that resides in the mitochondrial matrix where it regulates mitochondrial homeostasis through unknown mechanisms. This proposal aims to provide mechanistic insights into the non-apoptotic roles of mitochondrial matrix-localized MCL-1 and will shed light on the potential consequences of using MCL-1 inhibitors for clinical applications.

PI_NAMEs: WRIGHT, TRISTEN  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Address;Adoptive Transfer;Affect;Affinity;alpha ketoglutarate;Antioxidants;Apoptosis;Apoptotic;Autoimmunity;Back;BAX gene;BCL1 Oncogene;BCL2L1 gene;BCL2L11 gene;Binding;Bioenergetics;Biological Assay;Breeding;cancer cell;Cardiac Myocytes;Caspase Inhibitor;CD8-Positive T-Lymphocytes;Cell Death;Cell Lineage;Cells;Cessation of life;Citrates;Citric Acid Cycle;clinical application;Clinical Trials;confocal imaging;Confocal Microscopy;congenic;Crista ampullaris;Data;Defect;deprivation;Embryo;Embryonic Development;Environment;Epitopes;experimental study;Family;Fibroblasts;Flow Cytometry;Gene Expression Profile;Generations;Genus Hippocampus;Glutamine;Goals;Hematology;Hematopoietic stem cells;Homeostasis;Hour;Human Pathology;Immunoprecipitation;In Vitro;in vivo;inhibitor;insight;Investigation;Knock-out;Link;Listeria monocytogenes;Liver;Lymphocyte;Malates;Malignant Neoplasms;Mass Spectrum Analysis;MCL1 gene;Measures;Memory;Metabolic;Metabolism;metabolomics;Mitochondria;Mitochondrial Matrix;Morphology;Mouse Strains;mRNA sequencing;Mus;mutant;Mutant Strains Mice;Nerve Degeneration;Neurons;neutrophil;novel;OPA1 gene;Outer Mitochondrial Membrane;Ovalbumin;overexpression;Oxidative Phosphorylation;Oxygen Consumption;Pathology;Pathway interactions;Phosphorylation;Physiological;Physiology;Play;prevent;Production;Protein Dynamics;Protein Family;Protein Isoforms;Proteins;Reduced Glutathione;Regulation;Reporting;Resources;Respiration;Role;Saint Jude Children's Research Hospital;Scientist;small molecule inhibitor;Solid Neoplasm;Splenocyte;Spottings;Stains;Stress Tests;Structure;Supplementation;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;tool;Training;transcriptome sequencing;Transgenic Mice;Withdrawal

PROJECT_TITLE: Identifying the mechanisms behind non-apoptotic functions of mitochondrial matrix-localized MCL-1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: PROJECT NARRATIVE The buildup of fat or lipids in the liver contributes to the progression of alcohol-associated liver disease (ALD). We have discovered a protein, A-kinase anchoring protein (AKAP12), that interacts with proteins involved in controlling lipid content in the liver. Our proposal aims at investigating how the interactions of AKAP12 with these proteins can be preserved to prevent lipid accumulation and thereby control liver damage during ALD.

PI_NAMEs: RAMANI, KOMAL  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: A kinase anchoring protein;Adipose tissue;Adrenergic Receptor;Affect;alcohol effect;alcohol exposure;Alcoholic Liver Diseases;Alcohols;Binding;Cell membrane;comparison control;crosslink;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclin D1;Data;desensitization;Development;Disease Progression;Enzymes;Event;Exhibits;Fatty acid glycerol esters;fatty acid oxidation;Fatty Liver;Functional disorder;Gravin;Hepatic Stellate Cell;Hepatocyte;Homeostasis;Hsp47 protein;Human;Impairment;Lipase;lipid biosynthesis;Lipids;Lipolysis;Literature;Liver;Liver diseases;liver injury;Location;Maps;Mediating;MicroRNAs;mouse model;mRNA Expression;mRNA Stability;Mus;Mutate;Mutation;Nature;novel;Outcome;Pathway interactions;Pattern;Phosphopeptides;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;preservation;prevent;Process;protein expression;Protein Kinase;Proteins;Proteomics;Publishing;rab GTP-Binding Proteins;Rationalization;recruit;Recycling;Regulation;Role;scaffold;Scaffolding Protein;Signal Transduction;Site;spatiotemporal;Testing;Therapeutic;trafficking;Triglycerides;Work

PROJECT_TITLE: A-Kinase Anchoring Protein Dysregulation during Alcohol-Associated Liver Disease

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Cancer;Nanotechnology

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative I will develop an experimental pipeline that is broadly applicable to study the molecular mechanism of regulation and activation of membrane/membrane-associated proteins in the context of their endogenous environment, by extracting them while retaining an annular ring of their local protein and lipid interactome (native nanodiscs). These native nanodiscs can be used in several biophysical and biochemical analyses to understand the structural and functional organization, spatially-enriched endogenous proteomic and lipidomic environments, and ultimately bioactivity of target membrane proteins embedded in them. I propose to apply this pipeline and downstream analyses to investigate (1) a small, clinically relevant GTPase that is a hallmark oncogene, and (2) a receptor tyrosine kinase family that is critical for neuronal survival and development and plays a crucial role in pain perception.

PI_NAMEs: BHATTACHARYYA, MOITRAYEE  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: analog;Binding;Biochemical;Biological;Biological Assay;Biological Process;Biophysics;Cell membrane;Cellular Membrane;Chemicals;clinically relevant;copolymer;Dimensions;Disease;Encapsulated;Environment;Family;Frequencies;Goals;Guanosine Triphosphate Phosphohydrolases;Heterogeneity;Immune System Diseases;Impairment;interest;lipidome;lipidomics;Lipids;maleic acid;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;Membrane;membrane activity;Membrane Proteins;Molecular;Monomeric GTP-Binding Proteins;Mutation;nano;nanodisk;Nerve Degeneration;neuron development;neuronal survival;neurotrophic factor;Oncogenes;pain perception;Play;preservation;Property;protein function;Proteins;Proteome;Proteomics;Receptor Protein-Tyrosine Kinases;Regulation;Resolution;Role;Signal Pathway;Signal Transduction;Signaling Protein;single molecule;spatiotemporal;Styrenes;Total Internal Reflection Fluorescent

PROJECT_TITLE: Molecular mechanism of regulation and activation of membrane proteins in native membrane milieu

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BROOMFIELD

ORG_NAME: COLORADO STATE DEPARTMENT/AGRICULTURE

ORG_STATE: CO

PHR: FDA Laboratory Flexible Funding Model (LFFM) U19 Colorado Department of Agriculture Division of Laboratory Services Biochemistry Laboratory Public Health Relevance This cooperative agreement research proposal is submitted to FDA on behalf of the Colorado Department of Agriculture in consideration of enhancing and advancing the efforts for a nationally integrated food safety system. The Colorado Department of Agriculture, Biochemistry Laboratory will work with the FDA to protect the safety of the human and animal food supply and to enhance public health. Our work will support the goal “to enhance the capacity and capability of state human and animal food testing laboratories in support of an integrated food safety system” specifically to provide testing and defensible data to strengthen collaboration between FDA and state and local partners.

PI_NAMEs: MCCALLUM, KRISTINA JEAN (contact);PETTY, ERIC

PROGRAM_OFFICER_NAME: LI, MEI-YING

PROJECT_TITLE: Colorado Dept of Agriculture Application for the FDA LFFM PAR-20-105


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Infectious Diseases;Microbiome

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE Colorectal cancer (CRC) is the second most deadly cancer in the United States. The gut microbiome and specific bacterial species such as Fusobacterium nucleatum are associated with CRC. We seek to identify and validate F. nucleatum bioactivities that contribute to its potentiation of colorectal carcinogenesis using preclinical models.

PI_NAMEs: GARRETT, WENDY S. (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Acetates;adenoma;Adenosine Monophosphate;Amino Acids;Bacteria;Bacterial Adhesins;Bioenergetics;Biology;Cancer Model;CDX2 gene;Cell Physiology;Cell Proliferation;Cells;chemoradiation;Chemoresistance;Chemosensitization;Colon;colon carcinogenesis;Colon Carcinoma;colon tumorigenesis;Colonic Neoplasms;Colorectal Adenoma;Colorectal Cancer;colorectal cancer risk;Cysteine;Data;Detection;Epithelium;Feces;Fusobacteria;Fusobacterium nucleatum;Genes;Genomics;Gnotobiotic;Gram-Negative Anaerobic Bacteria;gut microbiome;gut microbiota;Human;Hydrogen Sulfide;hydroxyl group;Immune;Immunology;Immunooncology;In Vitro;in vivo;Individual;insight;lactate dehydrogenase A;Lipid A;Lipids;LoxP-flanked allele;Malignant Neoplasms;Mediating;Meta-Analysis;Metabolism;microbial;microbiome research;microbiota;microorganism;Modeling;Modification;mouse model;Mus;mutant;Myeloid Cells;Neoadjuvant Therapy;neoplastic cell;NF-kappa B;oral microbiome;Organoids;Patients;Phosphotransferases;Polysaccharides;Population;Post-Translational Protein Processing;pre-clinical;Pre-Clinical Model;Predisposition;Production;Progression-Free Survivals;protein profiling;Protein S;Proteins;Proteome;Rectal Cancer;Rectum;Relapse;rho GTP-Binding Proteins;Risk Factors;Role;Serine;Side;Spermidine Synthase;sulfhydration;T-Lymphocyte;Technology;Testing;Therapeutic;Threonine;Tissues;treatment response;Tryptophanase;tumor;tumor microenvironment;tumor-immune system interactions;Tyrosine;United States;Virulence;Volatile Fatty Acids;Work

PROJECT_TITLE: Colorectal carcinogenesis and Fusobacterium nucleatum: oncomicrobe, oncometabolites, and oncoimmunology

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Cancer;Chronic Pain;Estrogen;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Women's Health Research

ORG_CITY: BIDDEFORD

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NEW ENGLAND

ORG_STATE: ME

PHR: Project Narrative Chemotherapeutic agents are often dose limiting due to the emergence of a debilitating and painful neuropathy, posing a major challenge to the successful treatment of cancer. Post-menopausal breast and ovarian cancer patients are more at risk for developing paclitaxel-induced peripheral neuropathy. Characterizing neuron-immune communication and enhancing endogenous analgesic CD4+ T cells may provide a means for prophylactic and therapeutic intervention.

PI_NAMEs: GOODE, DIANA J (contact)

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: Affective;Afferent Neurons;Aftercare;aluminum sulfate;Analgesics;Anti-Inflammatory Agents;Antibodies;antinociception;Binding;Blocking Antibodies;Blood;Breast;Cancer Patient;cancer therapy;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Communication;Cell secretion;Cells;chemotherapeutic agent;Chemotherapy-induced peripheral neuropathy;Coculture Techniques;Color;Communication;Conflict (Psychology);Confocal Microscopy;copolymer 1;cytokine;Data;Data Set;Dose Limiting;ESR1 gene;Estradiol;Estrogen decline;Estrogen deficiency;Estrogen Therapy;Estrogens;experimental study;Female;Flow Cytometry;Histocompatibility Antigens Class II;Hormones;Hypersensitivity;Immune;In Vitro;in vivo;Induced Neurons;Inflammation;Injury;Interleukin-10;Interleukin-4;Intravenous;Lead;male;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Measures;Mechanics;Methods;MHC Class II Genes;Motivation;Multiple Sclerosis;Mus;Neuroglia;Neuroimmunomodulation;Neuronal Injury;Neurons;Neuropathy;neuroprotection;Non-Small-Cell Lung Carcinoma;novel;Ovarian;Ovariectomy;Paclitaxel;painful neuropathy;paracrine;Patients;Peripheral Nervous System Diseases;Pharmaceutical Preparations;Postmenopause;prevent;Preventive measure;Production;Proliferating;prophylactic;Proteins;Publishing;Reporting;response;Risk;Role;screening;Severities;Sex Differences;Signal Transduction;Source;Spinal Ganglia;System;T cell response;T-Cell Activation;T-Cell Depletion;T-Cell Proliferation;T-Lymphocyte;Tactile;Testing;Therapeutic Intervention;transcriptome sequencing;Visualization;Woman;women's treatment

PROJECT_TITLE: Novel expression of MHC class II on DRG neurons and its role in promoting antinociceptive CD4+ T cells in females during chemotherapy-induced peripheral neuropathy

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative This application is to support the Director of MICR, Dr. Kamiar Moin, the largest core facility of the Karmanos Cancer Institute which operate Wayne State University’s Cancer Center Support Grant. MICR develops and provides imaging and flow cytometry services to a number of NCI funded projects. Operation and management of such a facility requires a highly skilled scientist with both technical and administrative expertise.

PI_NAMEs: MOIN, KAMIAR  (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: analytical method;animal imaging;Applications Grants;Basic Science;Cancer Center;Cancer Center Support Grant;Capital;career;cellular imaging;Collaborations;Communities;Computers and Advanced Instrumentation;confocal imaging;Confocal Microscopy;Consultations;Continuing Education;Core Facility;cost;Cytometry;Dependence;Educational workshop;experience;Flow Cytometry;Funding;Grant;Image;Image Cytometry;Individual;instrument;International;Investigator-Initiated Research;Malignant Neoplasms;meetings;member;method development;Methodology;Microscopy;Mission;Multimodal Imaging;operation;parent grant;Peer Review;pre-clinical research;Publications;Research;Research Activity;Research Design;research facility;Research Personnel;Research Project Grants;Resources;Role;Scientist;Services;skills;Study Section;symposium;Techniques;Technology;technology development;technology validation;Tissue imaging;Training and Education;training opportunity;Travel;United States National Institutes of Health;Universities

PROJECT_TITLE: A stable path for a core based scientist to advance imaging and cytometry in basic and preclinical research at the Karmanos Cancer Institute


ORG_CITY: ANN ARBOR

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Narrative  In food allergies responses, the immune system reacts inappropriately towards food antigens resulting in inflammation and in the severe cases, death. We are designing biodegradable, biocompatible particles loaded with food allergens that tolerate such antigens, without inducing immune suppression, while maintaining the ability of the immune system to respond to pathogenic challenges. This innovative approach has far reaching implications for decreasing specific immune responses, such as the many forms of allergies or the rejection of transplanted cells in regenerative medicine.

PI_NAMEs: MILLER, STEPHEN D;SHEA, LONNIE D (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Acute Disease;Address;Adrenal Cortex Hormones;Adverse reactions;Affect;Allergens;Allergic;Allergic Disease;allergic response;Allergy to eggs;Allergy to peanuts;Anaphylaxis;anergy;anti-IgE;Antigen Presentation;Antigen-Presenting Cells;Antigens;Antihistamines;Apoptotic;arm;Autoimmune Diseases;B-Cell Activation;Basophils;Biodistribution;biomaterial compatibility;Celiac Disease;Cell Communication;Cell Physiology;Cell Transplantation;Cells;Cessation of life;Clinical;Clinical Research;clinical translation;Clonal Deletion;Complex;cost;Coupled;design;Developed Countries;Development;Disease;disease model;Disease remission;disorder prevention;Dose;Down-Regulation;Effector Cell;egg;Elements;Encapsulated;Epitope spreading;Evaluation;Experimental Autoimmune Encephalomyelitis;food allergen;food antigen;Food Hypersensitivity;Formulation;Foundations;Frequencies;Generations;Glycolic-Lactic Acid Polyester;Goals;Good Manufacturing Process;Graft Rejection;Health;Hepatic;Hypersensitivity;Immune;Immune response;Immune system;Immune System Diseases;Immune Targeting;Immune Tolerance;Immunity;Immunosuppression;Immunotherapy;in vivo;Individual;Inflammation;Inflammatory;inhibitor;innovation;Insulin-Dependent Diabetes Mellitus;Interleukin-13;Interleukin-4;Interleukin-5;intravenous administration;Intravenous infusion procedures;Investigation;Leukotrienes;Licensing;Liver;mast cell;Measures;Mediating;Memory;Modeling;Molecular;Molecular Weight;Multiple Sclerosis;multiple sclerosis patient;Mus;nanoparticle;nanoparticle delivery;omalizumab;particle;Pathogenicity;Pathology;Patients;Pharmacologic Substance;Phase;Phase I Clinical Trials;Phenotype;polarized cell;Polymers;Population;preservation;Prevalence;prevent;Prevention;Property;Proteins;Protocols documentation;Reaction;receptor expression;Recurrence;Regenerative Medicine;Regulatory T-Lymphocyte;Relapse;Research;response;Risk;Safety;side effect;Spleen;Splenocyte;surfactant;Symptoms;System;T cell anergy;T cell response;T-Cell Activation;T-Lymphocyte;Technology;Th2 Cells;trafficking;Translations;Up-Regulation;Vaccines;Work

PROJECT_TITLE: Allergen Loaded Nanoparticles for Food Allergy Tolerance

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: OVERALL PROJECT NARRATIVE The overarching goal of the Mid-Atlantic Center for Cardiometabolic Health Equity (MACCHE) is to test the effectiveness of comprehensive, integrated, and multi-level evidence-based strategies for improving cardiometabolic health outcomes among socially disadvantaged populations in Maryland, USA. The MACCHE will advance the science of cardiometabolic disease disparities and facilitate its translation into clinical and public health practice and policy.

PI_NAMEs: COOPER, LISA A (contact);CREWS, DEIDRA CANDICE

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Address;Adult;Baltimore;Black race;blood pressure control;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cardiorespiratory fitness;Chronic;Chronic Disease;Chronic Kidney Failure;Clinical;Cluster randomized trial;Collaborations;Communities;community academic partnership;community advisory board;community based participatory research;community engaged research;community engagement;Community Health Aides;community-centered;compare effectiveness;comparison intervention;Complex;data harmonization;Development;Diabetes Mellitus;disease disparity;Disease Management;disorder prevention;Disparity;Disparity population;Economics;effectiveness evaluation;effectiveness testing;Ethnic Origin;evidence base;Fibrosis;fitness;geographic disparity;Goals;Grant;Health;health disparity;health equity;Health equity research;Health Policy;Heart failure;Heart Injuries;High Risk Woman;Home Blood Pressure Monitoring;Home visitation;Hypertension;improved;Infrastructure;innovation;Institution;Intervention;Intervention Studies;Latinx;Leadership;Life Cycle Stages;Link;low socioeconomic status;Maryland;Mentors;Morbidity - disease rate;mortality;multidisciplinary;Myocardial dysfunction;Obesity;Outcome;Outcomes Research;Ownership;Patient Recruitments;patient retention;Patient-Focused Outcomes;Pharmacists;Phase;Pilot Projects;Policies;postpartum health;postpartum weight;Postpartum Women;Pregnancy;Pregnant Women;Problem Solving;programs;Provider;Public Health Practice;Quality of life;Race;randomized trial;Research;Research Personnel;Risk Factors;Science;Services;social disparities;socioeconomic disparity;Structure;team-based care;telemonitoring;Testing;Training;Translating;Translations;treatment as usual;United States;Universities

PROJECT_TITLE: The Mid-Atlantic Center for Cardiometabolic Health Equity (MACCHE)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

PI_NAMEs: COOPER, LISA A (contact)

PROJECT_TERMS: Achievement;Baltimore;Behavioral Sciences;Biometry;cardiometabolism;Clinical;Clinical Medicine;Clinical Trials Data Monitoring Committees;Collaborations;Communication;Communities;community advisory board;community based participatory research;community engagement;Consultations;Data Analytics;data management;data sharing;Databases;design;Development;Discipline of Nursing;Disparity population;effectiveness evaluation;effectiveness testing;Epidemiology;evidence base;Evidence based intervention;Expert Testimony;Faculty;Fostering;Funding;Goals;Grant;Health;Health Disparities Research;health disparity;health equity;Health Services Research;Health system;implementation science;improved;Individual;Influentials;informatics infrastructure;Information Dissemination;Institution;interest;International;Intervention;Intervention Trial;Interview;Knowledge;Learning;Maryland;Medical;meetings;member;Mid-Atlantic Region;Monitor;Outcome;Outcomes Research;Paper;Participant;Patient-Focused Outcomes;Policies;Policy Maker;population health;Process;Productivity;Public Health Practice;Publishing;recruit;Reduce health disparities;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;research study;Resources;Scientist;Series;Services;social disparities;standardize measure;Structure;success;Sum;therapy development;Training;Training and Education;Translating;Translations;Universities;University resources;Vulnerable Populations;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BEACH, MARY CATHERINE  (contact)

PROJECT_TERMS: Accountability;Address;African American;Area;Award;Baltimore;Behavior Therapy;Bioethics;Biomedical Research;Black race;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;career;career development;Centers of Research Excellence;Chronic;Chronic Disease;Chronic Kidney Failure;Clinical;Communities;community based participatory research;community building;community organizations;community partners;contextual factors;Dedications;Development;Diabetes Mellitus;disability;Disadvantaged;Discipline;Discipline of Nursing;disease disparity;Disparity;early-career faculty;Economically Deprived Population;Economics;Education;Educational process of instructing;Ensure;Ethics;Ethnic Population;Evaluation;experience;Faculty;faculty mentor;Food Access;forging;Funding;Goals;Grant;hands-on learning;Health;health care availability;Health Disparities Research;health disparity;health equity;Health equity research;Health Food;Health Policy;Health Services Research;Hispanic;Hypertension;implementation science;Income;Individual;individualized feedback;innovation;Institution;Institutional Review Boards;interest;Latinx;Leadership;Maryland;Medical Research;medical schools;meetings;Mentors;Methods;Mid-Atlantic Region;Modeling;Morbidity - disease rate;multidisciplinary;next generation;novel;Nursing Research;Obesity;Parents;Peer Review;Pilot Projects;Policies;Positioning Attribute;Postdoctoral Fellow;Prevention;programs;Public Health;racial population;racism;recruit;Reproducibility;Research;Research Methodology;Research Personnel;Research Training;responsible research conduct;Self Care;senior faculty;skills;social epidemiology;Social support;socioeconomic disadvantage;Specialized Center;statistics;Stress;Structure;success;System;Training;training opportunity;Training Programs;Underrepresented Populations;United States National Institutes of Health;Universities;Well in self;Work;Writing

PROJECT_TITLE: Investigator Development Core


ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative- Overall Patients with obstructive sleep apnea (OSA) suffer from repeated cycles of relaxation of airway muscles during sleep, resulting in closing of the airway, and inability to breath (apnea), followed by arousal, opening the airway, breathing, and then falling back asleep. These cycles can occur hundreds of times per night and result in sleep fragmentation, daytime sleepiness and cognitive impairment, and predispose to diabetes, high blood pressure, heart attack, and stroke. We are studying the brain circuits that are activated by apnea, in an effort to identify drugs that can prevent the airway from closing and to eliminate the repetitive awakenings, and the consequent cognitive, cardiovascular and metabolic problems in patients with OSA.

PI_NAMEs: SAPER, CLIFFORD B (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Address;airway muscle;airway obstruction;Apnea;Arousal;Atherosclerosis;Back;Basic Science;Brain;brain circuitry;Breathing;Calcium;Carbon Dioxide;Cardiovascular system;Cell Nucleus;cell type;Cells;Cognitive;Diabetes Mellitus;diabetes risk;Dilator;Dorsal;dorsal raphe nucleus;Drowsiness;Drug Combinations;Drug Design;Electroencephalography;falls;Fiber;follow-up;forkhead protein;FOXP2 gene;Genetic;genioglossus muscle;Goals;Human;Hypertension;Image;Impaired cognition;indexing;Lateral;Legal patent;lens;Maps;Mediating;Metabolic;Motor;Muscle;Muscle Tonus;Myocardial Infarction;Neurons;Obstructive Sleep Apnea;optogenetics;Outcome;parabrachial nucleus;Patients;Pharmaceutical Preparations;pharmacologic;Photometry;Physiological;Play;Population;prevent;Process;programs;Prosencephalon;rabies viral tracing;receptor;Recording of previous events;Relaxation;Research Personnel;respiratory;Respiratory Muscles;response;Role;Running;Seminal;Sensory;Serotonergic System;Serotonin;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Fragmentations;Stroke;synergism;System;Tidal Volume;Time;Translating;ventilation;Ventilator;Work

PROJECT_TITLE: Mechanisms of sleep and sleep apnea

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(OA)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Nutrition;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Health-related social needs, particularly food insecurity, housing instability, and transportation barriers, affect over 6 million people with type 2 diabetes mellitus, are associated with poor clinical. The proposed research program will significantly advance our understanding of how best to address health-related social needs in the context of diabetes management by testing longitudinal relationships between health-related social needs and diabetes outcomes, evaluating on-going health-related social needs interventions, and learning best practices for future interventions to adopt. This research program has the potential to improve health and reduce the impact of health-related social needs among individuals with diabetes.

PI_NAMEs: BERKOWITZ, SETH A (contact)

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: Accounting;Address;Adopted;Affect;Age;Area;Blood Pressure;Caring;Categories;Characteristics;cholesterol control;Clinic;Clinical;Communities;Complement;Complex;Complications of Diabetes Mellitus;Data;Data Element;data resource;Data Set;Data Sources;design;diabetes management;Diabetes Mellitus;Diastolic blood pressure;Dimensions;Disparity;Disparity population;Economic Conditions;effective intervention;Effectiveness;Ethnic Origin;Food;food insecurity;Frequencies;Future;Gender;Glycosylated hemoglobin A;Health;health equity;health management;Health Personnel;high risk;housing instability;improved;improved outcome;Individual;innovation;Intervention;Interview;Investigation;Knowledge;knowledge base;LDL Cholesterol Lipoproteins;Learning;Link;local economy;Location;Low-Density Lipoproteins;Machine Learning;machine learning method;Methods;Microvascular Dysfunction;Mission;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Neighborhood Health Center;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Outcome Study;Pathway interactions;Patients;Pattern;Persons;Population;population health;programs;Proliferating;Public Health Informatics;Qualitative Evaluations;Qualitative Research;Race;referral services;Regression Analysis;Reporting;Research;Resources;response;Risk;screening;Services;social;Social Environment;Social Work;Socioeconomic Status;Structure;Surveys;System;Target Populations;Testing;Transportation;Variant;Vulnerable Populations;Work

PROJECT_TITLE: SOCRATES: SOCial Risk and diAbetes ouTcomEs Study

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Lung;Sleep Research

PROJECT_TERMS: Address;Annual Reports;Back;Budgets;Data Analyses;Expenditure;Feedback;Funding;Future;Genes;Human Resources;Institution;interest;Intervention;meetings;Occupational activity of managing finances;Participant;Persons;pharmacologic;Program Research Project Grants;programs;Published Comment;Reporting;Research;Research Personnel;Science;Services;Sleep;Sleep Apnea Syndromes;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Core A

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


PI_NAMEs: FULLER, PATRICK M (contact)

PROJECT_TERMS: adeno-associated viral vector;Bioinformatics;Brain region;Breeding;Cell Nucleus;cell type;Cells;cost;Data Set;Development;differential expression;EGR2 gene;Elements;Engineering;Enterobacteria phage P1 Cre recombinase;experience;experimental study;FLP recombinase;FOXP2 gene;Funding;Generations;Genes;Genetic;genetic manipulation;Genetic Recombination;Genotype;Goals;Histocytochemistry;Histologic;improved;In Situ Hybridization;In Vitro;in vivo evaluation;interest;Laboratories;Maintenance;Methods;Microinjections;Mission;Molecular;Molecular Biology;mRNA Expression;Mus;Mutant Strains Mice;neural;neurochemistry;Neurons;pharmacologic;Phenotype;Plasmids;Preparation;Production;promoter;Protocols documentation;Publications;Recombinants;Scheme;Series;Services;Signal Transduction;single nucleus RNA-sequencing;Sleep;Sleep Apnea Syndromes;Specificity;success;Techniques;Technology;Tissues;tool;Toxic effect;Toxin;transcriptomics;Transgenic Organisms;Update;Viral;Viral Vector;Work

PROJECT_TITLE: Core B


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: IBE, CHIDINMA ADANNA (contact)

PROJECT_TERMS: Active Learning;Adoption;Advisory Committees;Affect;Apical;cardiometabolism;Collaborations;Communication;Communities;community advisory board;community based participatory research;community engaged approach;community engaged research;community engagement;community involvement;community organizations;Community Outreach;community-centered;Consult;Decision Making;design;Disparity;Education and Outreach;effective intervention;empowerment;Ensure;Environment;Equity;Ethnic Origin;experience;Goals;Health;Health Disparities Research;health equity;Health equity research;health inequalities;human centered design;Individual;Infrastructure;innovation;Intervention;Leadership;Learning;Lived experience;marginalized community;Mid-Atlantic Region;Modeling;Outcome;Ownership;Pathway interactions;Pattern;Phase;Policies;Positioning Attribute;Process;programs;Race;Research;Research Activity;Research Personnel;research study;Resources;Shapes;social;social health determinants;Social Justice;structural determinants;Structure;success;System;Textiles;Thinking;tool;Training;Translating;Translations;Update;Voice

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Lung;Neurosciences;Sleep Research

PI_NAMEs: ARRIGONI, ELDA  (contact)

PROJECT_TERMS: adeno-associated viral vector;antagonist;Bathing;Brain;Calcium;calcium indicator;Cells;Characteristics;Clozapine;Code;Core Facility;Cre driver;Data;designer receptors exclusively activated by designer drugs;efficacy testing;Electrophysiology (science);Ensure;Experimental Genetics;experimental study;extracellular;Genetic;Graph;Histological Techniques;Histology;Image;imaging study;Imaging Techniques;In Vitro;in vivo;Institution;Ivermectin;Laboratories;Light;Maps;Measures;Monitor;Mus;Nerve;neurochemistry;Neurons;Neurotransmitters;novel;optogenetics;Oxides;patch clamp;Physiologic pulse;Population;Population Study;postsynaptic;postsynaptic neurons;Property;Protocols documentation;Publications;Publishing;receptor;Reporter;Research Design;Research Personnel;Resource Sharing;Resources;response;Services;Sleep;Sleep Apnea Syndromes;Slice;Statistical Data Interpretation;Synapses;Techniques;tool;Update;Whole-Cell Recordings;Work

PROJECT_TITLE: Core C


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Lung;Neurosciences;Sleep Research

PROJECT_TERMS: airway obstruction;Animals;Apnea;Arousal;Brain;Calcium;Carbon Dioxide;Cardiovascular system;Cells;Chloride Channels;Clozapine;Cognitive;Data;Dilator;Dorsal;Dose;Electroencephalography;Fiber;Fire - disasters;FOXP2 gene;Genetic;genioglossus muscle;Goals;Human;Hypercapnia;hypoglossal nucleus;Hypoxia;Image;Impaired cognition;indexing;Individual;individual response;Lateral;lens;Measures;Metabolic;Monitor;Motor;Mus;Muscle;Muscle Tonus;Neurons;Nucleus solitarius;Obstructive Sleep Apnea;optogenetics;Outcome;Oxides;parabrachial nucleus;Patients;Pattern;pharmacologic;photoactivation;Photometry;Play;Population;preBotzinger complex;prevent;Prosencephalon;Ramp;receptor;respiratory;Respiratory Muscles;Respiratory System;response;Rodent;Role;Signal Transduction;Site;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Fragmentations;Stimulus;Testing;therapy design;Tidal Volume;transcription factor;transmission process;ventilation

PROJECT_TITLE: Project 1


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Kidney Disease;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth

PI_NAMEs: COMMODORE-MENSAH, YVONNE  (contact)

PROJECT_TERMS: Address;Adherence;Adoption;Adult;Affect;African American population;American;Behavioral;Biological;Black race;Blood Glucose;Blood Pressure;blood pressure control;Blood Pressure Monitors;Bluetooth;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;care delivery;Caring;Cessation of life;Chronic;Chronic Disease;Chronic Kidney Failure;Clinic;Clinical;clinical decision-making;Communities;Community Health Aides;Complex;contextual factors;COVID-19 pandemic;Data;design;Devices;diabetes control;Diabetes Mellitus;diabetes risk;digital;disease disparity;Disease Management;Disparity;Disparity population;disparity reduction;dissemination strategy;Education;effectiveness/implementation design;empowerment;Engineering;Enrollment;ethnic minority population;Ethnic Population;evidence based guidelines;experience;glucose monitor;Glycosylated hemoglobin A;Health;Health behavior;health care availability;health disparity;health equity;Health Professional;Health Services Accessibility;Health system;Health Technology;Healthcare;High Prevalence;high risk;Hispanic;Hispanic Populations;Home;Hybrids;Hypertension;hypertension control;Improve Access;improved;Individual;innovation;Intervention;Kidney Diseases;Latino Population;Link;Maintenance;Measures;mHealth;Minority Groups;monitoring device;Morbidity - disease rate;mortality;Not Hispanic or Latino;Organ;outcome disparities;patient monitoring device;patient oriented;Patient-Focused Outcomes;Patients;Persons;Pharmacists;Policies;Practical Robust Implementation and Sustainability Model;premature;Prevalence;prevent;Primary Care;primary care practice;primary outcome;programs;Provider;Qualifying;racial minority;racial minority population;racial population;Randomized;randomized trial;Randomized, Controlled Trials;remote patient monitoring;secondary outcome;Self Management;social;social culture;social determinants;social health determinants;Soil;Stroke;System;team-based care;telehealth;telemonitoring;Transportation;Underserved Population;Uninsured;Visit;Work

PROJECT_TITLE: A Cardiometabolic Health Program LINKED with Clinical-Community Support and Mobile HEAlth TelemonitoRing in Underserved PopulaTionS (LINKED-HEARTS PROGRAM)


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Estrogen;Regenerative Medicine;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE An individual’s biological sex impacts their ability to repair tissue and maintain homeostasis. This proposal will utilize biomaterial technologies to interrogate sex differences in tissue repair by decoupling cell microenvironment and estrogen signaling to determine the role of each parameter independently on tissue repair using mesenchymal stromal cells (MSCs). This work will have broad implications for the design, development, and implementation of biomaterial therapies tailored to a patient’s sex to promote tissue repair, regeneration, and homeostasis.

PI_NAMEs: ROBINSON, JENNIFER LINDSEY (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;Affect;Age;Architecture;Behavior;Biocompatible Materials;biological sex;Biomechanics;Brain Diseases;Cardiovascular Diseases;cell behavior;Cell Physiology;Cells;Chemistry;Collagen;Degenerative Disorder;Degenerative polyarthritis;design;Development;Diffusion;Engineering;Environment;Estrogens;Extracellular Matrix;Female;Future;Genetic Transcription;Goals;Gonadal Steroid Hormones;healing;Homeostasis;hormonal signals;Hormones;Hour;Individual;individualized medicine;male;mechanical properties;mechanical signal;Mechanics;Mediating;men;mesenchymal stromal cell;microchip;Natural regeneration;nutrition;Osteoporosis;patient oriented;Patients;Phenotype;Physical activity;Postmenopause;programs;Property;Proteoglycan;repaired;Research;response;Risk;Role;sex;Sex Differences;Signal Transduction;Site;stem cells;Structure;System;Technology;tissue regeneration;tissue repair;Tissues;tool;viscoelasticity;Woman;Work

PROJECT_TITLE: Biomaterial technologies for interrogating sex differences in tissue repair and homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


PI_NAMEs: SCAMMELL, THOMAS E (contact)

PROJECT_TERMS: Address;Affect;Afferent Pathways;Air Movements;airway obstruction;Anatomy;Arousal;Automobile Driving;Binding;Brain Stem;Calcitonin Gene-Related Peptide;Calcium;Continuous Positive Airway Pressure;Drowsiness;Electroencephalography;experimental study;Exposure to;Fiber;Frequencies;Goals;Hypercapnia;Hypothalamic structure;Image;improved;In Situ Hybridization;In Vitro;Lateral;Maps;Measures;Mechanoreceptors;method development;Methods;multidisciplinary;Mus;neurochemistry;neuromechanism;Neurons;Obstructive Sleep Apnea;parabrachial nucleus;Pathway interactions;Patients;Pattern;Persons;Pharmaceutical Preparations;pharmacologic;Photometry;preservation;prevent;Prosencephalon;receptor;receptor expression;receptor function;Recurrence;respiratory;response;Signal Pathway;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep disturbances;Slice;Synapses;synergism;Techniques;Tidal Volume;Time;translational impact;ventilation

PROJECT_TITLE: Project 2


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Precision Medicine;Prevention

ORG_CITY: SHELBURNE

ORG_NAME: PROLOCOR INC.

ORG_STATE: VT

PHR: NARRATIVE The American Heart Association estimates that, in 2022, about 720,000 Americans will have a first coronary event and 335,000 will have a recurrent event, of which, approximately 87% are ischemic (thrombotic). Anti- thrombotic therapy reduces the risk of recurrent ischemic events at the cost of a greater incidence of bleeding complications thus necessitating an effective precision tool that can guide individualized therapy to manage this risk assessment. This proposal will address this need by establishing sensitivity, specificity, and reproducibility of the Prolocor prototype commercial assay – high platelet FcγRIIa expression – as a diagnostic tool for determination of thrombotic/ischemic risk.

PI_NAMEs: OHRNBERGER, JEANNE  (contact);SCHNEIDER, DAVID J

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: acute coronary syndrome;Address;Age;Agonist;Agreement;American;American Heart Association;Antibodies;Assessment tool;Binding;Biological Assay;Biological Markers;Blood Platelets;cardiovascular risk factor;Cardiovascular system;Caring;Cessation of life;CLIA certified;Clinical;clinical risk;Collaborations;commercial prototype;coronary event;cost;design;Detection;Diabetes Mellitus;Diagnostic Reagent Kits;diagnostic tool;Ensure;Event;experimental study;Feedback;Flow Cytometry;Formaldehyde;Future;Goals;hazard;Hemorrhage;Incidence;Individual;individual variation;individualized medicine;Instruction;Ischemia;Laboratories;laboratory experience;Malignant Neoplasms;Measurement;Measures;Medicine;Methods;Myocardial Infarction;novel;Observational Study;Patient Care;Patients;Performance;performance tests;phase III trial;Pilot Projects;Platelet Activation;Platelet Function Tests;precision medicine;prognostic;prospective;Reagent;Recurrence;Regression Analysis;Regulation;Reproducibility;Research Proposals;Residual state;response;revascularization;Risk;Risk Assessment;Risk Management;Risk Reduction;Sampling;Sensitivity and Specificity;Site;Small Business Innovation Research Grant;Specificity;Stroke;Surface;System;Testing;thrombotic;tool;trial design;uptake;Validation;Variant

PROJECT_TITLE: Validation of Platelet Expression of FcɣRIIa as a Precision Tool

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(10)B]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Dengue and Zika viruses are globally emerging infectious diseases. Development of a vaccine that provides broad protection against the four Dengue virus serotypes has been technically challenging. A single effective vaccine against both Dengue and Zika viruses is highly desirable. We employ innovative protein engineering approaches to develop subunit vaccines based on key neutralizing epitopes of the Dengue and Zika envelope glycoproteins.

PI_NAMEs: LAI, JONATHAN R. (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute;Address;Antibodies;Antibody Response;Antibody titer measurement;Antibody-Dependent Enhancement;Antigens;Attenuated;Attenuated Vaccines;Binding;Binding Sites;Cells;Cessation of life;Characteristics;Complex;Country;cross reactivity;Culicidae;Dengue;Dengue Fever;Dengue Vaccine;Dengue Virus;Dengvaxia;design;Development;dimer;Disease;Emerging Communicable Diseases;Engineering;Epitopes;Europe;European Union;Evaluation;Exhibits;Fever;Flavivirus;flavivirus glycoprotein E;Geometry;Glycoproteins;glycosylation;Goals;Head;Hospitalization;Human;IgG Receptors;Immune;Immune response;Immunity;Immunization;Immunize;Individual;Infection;innovation;Lateral;Licensing;Licensure;manufacture;Masks;Membrane;Membrane Fusion;Membrane Proteins;Methods;Molecular;Monoclonal Antibodies;Motion;Mus;Mutation;nanoparticle;neutralizing antibody;neutralizing monoclonal antibodies;next generation;novel;particle;Patients;Phage Display;phase III trial;Polysaccharides;premature;Primary Infection;Protein Engineering;Proteins;Rapid screening;receptor;receptor binding;Reporting;response;Risk;Safety;secondary infection;Serotyping;severe dengue;Shock;Site;Structure;Subunit Vaccines;Surface;Syndrome;System;Tail;Testing;transmission process;vaccine candidate;Vaccine Design;vaccine development;vaccine strategy;Vaccines;Variant;vector vaccine;Viral;Virus;Work;Yellow fever virus;ZIKA;Zika Virus

PROJECT_TITLE: Structure-based design of broad flavivirus immunogens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(02)]


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE Mechanisms that Govern Cardiomyocyte Proliferation and Remuscularization following Ventricular Injury Program Overall The studies comprising this Program Project Grant application will examine mechanisms whereby CMs reenter the cell cycle and new strategies to remuscularize the heart with postinfarction LV remodeling. Project 1 will identify the CM cell-cycle regulators that are activated by MI in one-day-old pigs and construct human cardiac muscle patches (hCMP) of unprecedented clinically relevant dimensions from layers of proliferating hiPSC-CMs with activated cell cycle regulators, and other cardiac cells, and will determine whether the identified factors and hCMPs can remuscularize the hearts of adult pigs after MI; Project 2 will use genetic strategies, viral vectors, and modified RNAs to investigate members of the Sonic Hedgehog signaling pathway including: Gli1 and Sox4, which have already been shown to induce proliferation in cultured CMs, can also promote CM proliferation in the injured hearts of adult mice and pigs, and studies will examine the capacity of the master regulator, Etv2, to promote neovascularization to repair the injured hearts of adult mice and pigs; Project 3 will use gain and loss of function in mice and pigs to determine the role of oxygen metabolism in regulation of cardiomyocyte cell cycle. The central objective of this PPG proposal is to remuscularize the injured ventricle from “within,” by promoting endogenous CM proliferation, and from “outside,” by transplanting functionally mature hCMPs that are primed for in vivo CM proliferation.

PI_NAMEs: ZHANG, JIANYI  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Acceleration;Acute myocardial infarction;Address;Adult;angiogenesis;Animals;Applications Grants;Bioinformatics;Biomedical Engineering;Birth;Blood Vessels;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;Cardiovascular system;Cell Cycle;Cell Cycle Arrest;Cell Cycle Regulation;Cell Therapy;Cells;Chronic;Cicatrix;Clinical Research;clinically relevant;Collaborations;Complement;Congestive Heart Failure;Data;Dimensions;Engraftment;experimental study;Family suidae;Future;gain of function;genetic approach;Goals;Heart;Heart failure;heart function;Heart Injuries;Human;human induced pluripotent stem cells;Hypoxia;in vivo;Infarction;injured;Injury;injury and repair;ischemic injury;Laboratories;Left Ventricular Remodeling;Left ventricular structure;Ligation;loss of function;Mammalian Cell;Mammals;Mediating;member;Metabolism;Mitochondria;Molecular;Mus;Muscle;Muscle Cells;Myocardial;Myocardial Infarction;Myocardium;Neonatal;neovascularization;overexpression;oxidative DNA damage;Oxygen;Pathway interactions;Patients;porcine model;postnatal;Production;Program Research Project Grants;programs;Proliferating;Proline;Public Health;Records;Regulation;repaired;Research;Research Personnel;RNA;Role;Science;SHH gene;Signal Pathway;Signal Transduction;smoothened signaling pathway;SOX4 gene;synergism;Testing;Time;Tissues;Transplantation;Treatment Protocols;Ventricular;Viral Vector;Work

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(MA)]


PROJECT_TERMS: Agonist;Agreement;airway obstruction;Anatomy;Arousal;Automobile Driving;Brain Stem;Calcium;Carbon Dioxide;Cardiovascular system;Cell Nucleus;Cells;Clinical;Cognitive;Data;Development;Dissociation;Electroencephalography;Endocrine;Event;Excessive Daytime Sleepiness;experimental study;Exposure to;FOXP2 gene;Glutamates;Goals;Heterogeneity;Hypercapnia;Image;improved;In Situ Hybridization;In Vitro;innovation;Knowledge;Lateral;Legal patent;Maps;Measures;method development;Methods;Molecular;Motor;Motor Neurons;Mus;neurochemistry;Neurons;novel;Obstructive Sleep Apnea;parabrachial nucleus;Pathologic;Pathway interactions;Patients;Pattern;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;photoactivation;Photometry;Play;Population;Positioning Attribute;presynaptic;Prosencephalon;Public Health;Rabies;receptor;receptor expression;Recurrence;Regulation;Reporting;Research;Respiration Disorders;respiratory;response;Role;Signal Transduction;single nucleus RNA-sequencing;Sleep;Sleep Apnea Syndromes;Sleep disturbances;Sleep Fragmentations;Surveys;Synapses;synergism;Testing;Time;transcriptome;transcriptomics;translational impact;treatment strategy;ventilation;Work

PROJECT_TITLE: Project 3


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

PI_NAMEs: BOWER, KELLY  (contact)

PROJECT_TERMS: Acute;Address;Adoption;adverse pregnancy outcome;Behavior;Behavioral;Black race;black women;Breast Feeding;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular system;Cellular Phone;Child Rearing;Chronic Disease;Communities;community partnership;comorbidity;compare effectiveness;design;Diabetes Mellitus;Diet;disease disparity;disorder risk;disparity elimination;Effectiveness;effectiveness-implementation RCT;effectiveness/implementation trial;Enabling Factors;Enrollment;Event;evidence base;experience;Family;Future;Gestational Diabetes;gestational weight gain;Growth;Health;Health behavior;health care service utilization;health disparity;health equity;Health Promotion and Education;healthy lifestyle;High Prevalence;high risk;High Risk Woman;Home;Home visitation;Hybrids;Hypertension;implementation evaluation;implementation intervention;implementation science;Infant;Infant Care;infant outcome;innovation;intergenerational;Intervention;Language;Latinx;Leadership;Learning;lifestyle intervention;Link;Low income;Maryland;Maternal Health;Maternal Health Services;Maternal Mortality;maternal outcome;Mental Depression;Morbidity - disease rate;motivational enhancement therapy;Newborn Infant;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity in pregnancy;outcome disparities;Participant;Pathway interactions;Patients;Physical activity;pilot test;postpartum health;Postpartum Period;postpartum weight;Postpartum Women;Pregnancy;Pregnancy Complications;Pregnant Women;prepregnancy;prepregnancy obesity;prevent;programs;Public Health;remote delivery;Research;Resources;Risk;Role;safety net;Services;Sleep;smoking cessation;social health determinants;social stress;Social support;Spanish;telephone coaching;Testing;Training;Translations;United States;United States Public Health Service;Visit;web platform;Weight;White Women;Woman

PROJECT_TITLE: Effectiveness of an evidence-based health coaching program for reducing cardiometabolic risk among women and infants enrolled in early home visiting services


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Lung;Neurosciences;Sleep Research

PI_NAMEs: VANDERHORST, VERONIQUE  (contact)

PROJECT_TERMS: Adult;Anatomy;Arousal;Atherosclerosis;Biological Assay;Blood;Brain;Brain Stem;Breathing;Calcium;Carbon Dioxide;Cardiovascular Physiology;Cardiovascular system;Cell Nucleus;combat;comorbidity;Continuous Positive Airway Pressure;Dependence;designer receptors exclusively activated by designer drugs;Development;Dilator;Drops;Drowsiness;Dyspnea;EGR2 gene;Electroencephalography;Excessive Daytime Sleepiness;falls;Genetic;genioglossus muscle;Heart Rate;HTR2A gene;Hypercapnia;Hypertension;Imaging Device;Impaired cognition;improved;In Vitro;in vivo;innovation;Intervention;Maps;Measures;Mediating;Medical;Metabolic;Metabolic syndrome;middle age;Modeling;Molecular;Motor;Motor Activity;Movement;Mus;Muscle;Muscle Tonus;neural;Neurons;Nucleus solitarius;Obstructive Sleep Apnea;optogenetics;Oxygen;pharmacologic;Population;preBotzinger complex;pressure;prevent;programs;Property;Rabies virus;Receptor Signaling;Recombinant adeno-associated virus (rAAV);Recurrence;respiratory;Respiratory Acidosis;Respiratory Diaphragm;response;Role;Sensory;Serotonin;serotonin 7 receptor;serotonin receptor;Site;Sleep;Sleep Apnea Syndromes;Sleep Fragmentations;Slice;Stress;Synapses;System;Tachycardia;Therapeutic;Tidal Volume;Tissues;tool;transcriptomics;Transgenic Organisms;Validation;vasoconstriction;ventilation;Visualization;Wakefulness;Work

PROJECT_TITLE: Project 4


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Neurosciences;Prevention;Sleep Research

PI_NAMEs: WELLMAN, DAVID ANDREW (contact)

PROJECT_TERMS: Affect;airway muscle;airway obstruction;Animal Experimentation;Animal Experiments;antagonist;Apnea;Area;Arousal;atomoxetine;Brain Stem;Carbon Dioxide;Cell Nucleus;Cephalic;Clinical Trials;Collaborations;Data;differential expression;Dilator;Disease;Drug Combinations;druggable target;Effectiveness;Electroencephalography;Event;experience;Functional disorder;gabapentin;Glean;Goals;Grant;Human;human data;Impaired cognition;improved;indexing;Individual;inhibitor;Intention;Light;Measures;Mediating;member;Methods;Motor;Muscarinics;Muscle;Muscle hypotonia;Muscle Tonus;Neurons;non rapid eye movement;Norepinephrine;novel therapeutics;Obstructive Sleep Apnea;Outcome;oxybutynin;Oxygen;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Pharyngeal structure;pharynx muscle;Phenotype;Physiological;Placebos;Predisposition;prevent;Prevention;receptor;receptor expression;REM Sleep;Research;respiratory;response;reuptake;sedative;Series;Serotonin;Serotonin Agonists;Serotonin Antagonists;serotonin receptor;Severities;side effect;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Sleep Stages;Stimulant;Testing;trait;Trazodone;Urinary Retention;Withdrawal;Xerostomia;zolpidem

PROJECT_TITLE: Project 5


PHR: NARRATIVE  (Core A) Administrative Core The Administrative Core (Core A) will work closely with Dr. Jay Zhang to provide the leadership and organizational structure needed to maximize the synergy of this highly integrated and collaborative Program, the activities of which are summarized under the following specific aims (SAs) and sub-Aims: SA1 - Provide leadership and promote synergy among Projects and Cores - The Administrative Core will lead and coordinate the activities of all Projects and Cores in this PPG; SA2 - Maximize communication among Program Leaders, Trainees, and Advisors - Core A will lead and ensure the success of this collaborative Program for an unrelenting commitment to maximum communication among all involved personnel, including Project and Core Leaders, trainees, and staff, as well as members of the Steering and Scientific Oversight Committees and the Internal and External Advisory Boards; and SA3. Manage the administrative, fiscal, and compliance responsibilities of all Projects and Cores - Ensure compliance with all University, State, and Federal oversight agencies.

PROJECT_TERMS: Acceleration;Adult;Alabama;Animals;Antibodies;Archives;Budgets;Cardiac Myocytes;Cardiovascular system;career development;Cell Line;cloud storage;Collaborations;Communication;Computer Workstations;Congestive Heart Failure;Data;Data Analyses;delivery vehicle;Development;Documentation;Employee Health;Ensure;Environmental Health;experimental study;Family suidae;Genes;Guidelines;Human Resources;IACUC;Individual;induced pluripotent stem cell technology;Injury;Institution;Knockout Mice;Laboratories;Lead;Leadership;meetings;member;Minnesota;Monitor;Muscle;Neonatal;novel;Office of Administrative Management;organizational structure;Patients;Persons;Plasmids;Policies;Postdoctoral Fellow;Preparation;Procedures;programs;Progress Reports;Proliferating;Protocols documentation;Reagent;Regulation;Reporting;Research;Research Personnel;Resources;Rotation;Safety;sample collection;Schedule;Site;Social Distance;Statistical Data Interpretation;Students;success;synergism;System;Texas;Tissue Engineering;Tissue Sample;tool;Transgenic Organisms;Transportation;Universities;Ventricular;Viral Vector;Work

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: NDUMELE, CHIADI E (contact)

PROJECT_TERMS: Address;African American population;Ambulatory Care;barrier to care;Behavior Therapy;cardiometabolism;cardiorespiratory fitness;Clinical;clinical risk;Communities;community based participatory research;Community Health;Community Health Aides;community partners;Complications of Diabetes Mellitus;Computerized Medical Record;cost;Data;Diabetes Mellitus;dietary;Disparity;Education;Educational Intervention;ethnic minority;ethnic minority population;Ethnic Origin;Evaluation;evidence base;experience;Feedback;Fibrosis;fitness;Functional disorder;functional status;geographic disparity;geographic risk;Glycosylated hemoglobin A;Guidelines;health care availability;health disparity;health equity;Health system;healthy lifestyle;Heart failure;Heart Injuries;Impairment;improved;improved outcome;Individual;interest;Intervention;intervention refinement;Latino Population;Life Style;Link;low socioeconomic status;member;Morbidity - disease rate;mortality;Myocardial dysfunction;Native Americans;neighborhood association;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;outcome disparities;Outcomes Research;patient engagement;Patient-Focused Outcomes;Patients;Persons;Physical activity;Physiological;Population;pragmatic intervention;prevent;Prevention;preventive intervention;primary outcome;Problem Solving;Prognosis;prognostic;programs;Public Health;Quality of life;Race;racial minority;racial minority population;randomized trial;Randomized, Controlled Trials;Resources;Risk;Risk Factors;Rural;rural setting;Self Management;social health determinants;Socioeconomic Status;suburb;support network;Support System;Target Populations;Testing;Training;urban setting;Visit;Work

PROJECT_TITLE: Understanding and addressing risks of low socioeconomic status and diabetes for heart failure


PHR: NARRATIVE  (Core B) Large Animal Model and Electrophysiology Core All three Projects in this P01 include experiments in neonatal and adult pigs, which are typically too complex and expensive to be conducted in an individual lab. Thus, by providing a centralized facility for all surgical procedures, functional assessments and electrophysiological evaluations, the Large Animal Core (Core B) will maximize data quality and experimental efficiency while minimizing the costs associated with these studies.

PI_NAMEs: WALCOTT, GREGORY P (contact)

PROJECT_TERMS: Acceleration;Adult;Alabama;Animal Model;animal resource;Animals;Archives;Arrhythmia;Bioinformatics;biological preparation;Cardiac;Cardiac Myocytes;Cell Cycle;Complex;cost;Data;Data Analyses;data quality;Documentation;Echocardiography;Electric Stimulation;Electrophysiology (science);Ensure;Equipment;Evaluation;experience;experimental study;Family suidae;Gene Delivery;good laboratory practice;heart function;heart rhythm;hemodynamics;histological specimens;Housing;Human Engineering;Human Resources;Implant;in vivo;Individual;Injury;Investigational Therapies;Laboratories;Leadership;Magnetic Resonance Imaging;Mammals;Maps;Mediating;Methods;Modeling;Molecular Analysis;Monitor;Muscle;Myocardial;myocardial injury;Myocardial tissue;Neonatal;operation;Operative Surgical Procedures;Optics;Perioperative Care;Predisposition;Procedures;Process;programs;Proliferating;protocol development;Protocols documentation;Regulator Genes;Reporting;Reproducibility;Research Personnel;Resources;Sampling;Secure;Site;skills;Structure;Surgeon;Tissues;Training;Transplantation;treatment effect;Universities;Ventricular;Veterinarians

PROJECT_TITLE: Core B - Large Animal Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Networking and Information Technology R&D (NITRD);Regenerative Medicine

PHR: NARRATIVE  (Core C) Bioinformatics Core The mechanisms that govern cardiomyocyte proliferation and remuscularization following a heart attack are unknown. The overall goal for Core C: The Bioinformatics Core is to assist all the projects with their data analyses to promote discovery and facilitate their research aimed at the definition of future therapeutic factors that will facilitate cardiomyocyte proliferation and heart regeneration.

PI_NAMEs: GONG, WUMING  (contact)

PROJECT_TERMS: Address;Algorithms;Applications Grants;ATAC-seq;Bioinformatics;bioinformatics tool;Biological;Biotechnology;Cardiac;Cardiac Myocytes;cardiac regeneration;Cardiovascular system;ChIP-seq;Collaborations;Computational algorithm;Computer Models;Computer software;Core Facility;Critical Pathways;Data;Data Analyses;Data Set;design;Ensure;Equipment;experimental study;Family suidae;Future;Generations;Genes;Genetic Transcription;Genomics;Goals;Human Resources;improved;Injury;Laboratories;laboratory experiment;Left;member;Metabolism;metabolomics;Modernization;Mus;Muscle;Myocardial;Myocardial Infarction;Natural regeneration;next generation;next generation sequence data;next generation sequencing;novel;Pathway interactions;Process;programs;Proliferating;Proline;Proteomics;Publications;Regulation;Regulatory Pathway;repaired;Reproducibility;Research;Research Personnel;Resources;Role;Services;Signal Pathway;single-cell RNA sequencing;skills;Techniques;Therapeutic;Time;Training;transcriptome sequencing;Ventricular;Visualization

PROJECT_TITLE: Core C - Bioinformatics Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

PHR: NARRATIVE  (Project 1)  Endogenous and Exogenous Mechanisms that Promote Myocardial Remuscularization in Postinfarction LV Remodeling  The molecular and cellular basis for the progressive heart failure is the result of the inability of damaged and apoptotic myocytes to be replaced. The central objective of this proposal is to “turn back the clock” of myocyte cell cycle for myocardial regeneration. The Specific Aims (SA) are SA1: fate mapping and identifying the key regulators that promote cell-cycle activity in the hearts of early neonatal pigs after myocardial injury; SA2a: engineering hCMPs containing CMs that are capable of proliferating and characterized by previously unattainable size and thickness that are functionally mature and primed for in-vivo vascularization; and SA2b: evaluating the effectiveness of our hCMP constructs for myocardial recovery and remuscularization in a large- animal (swine) model of myocardial injury with the state-of-the-art techniques of optical mapping in combination with the 3-dimensional intramural cardiac mapping to delineate potential arrhythmia mechanisms over the entire heart.

PROJECT_TERMS: 3-Dimensional;Acute myocardial infarction;adeno-associated virus 9 delivery;Adult;Animals;Apoptotic;Arrhythmia;Back;Biomedical Engineering;Birth;Blood Vessels;Cardiac;Cardiac Myocytes;cardiac tissue engineering;CCND2 gene;Cell Cycle;Cell Line;Cell Nucleus;Cell Proliferation;Cell Survival;Cell Transplantation;cell type;Cells;Cicatrix;clinically relevant;Congestive Heart Failure;Cues;Dilatation - action;Dimensions;effectiveness evaluation;Electric Stimulation;Endogenous Factors;Endothelial Cells;endothelial stem cell;Engineering;Engraftment;Family suidae;Fibroblasts;Functional disorder;functional improvement;Generations;Heart;Heart failure;heart function;Human;Human Engineering;human induced pluripotent stem cells;Imaging technology;improved;in vivo;Infarction;injured;Injury;ischemic injury;Left;Left Ventricular Remodeling;Left ventricular structure;Mammals;manufacture;Maps;mature animal;Measurement;Modeling;Molecular;Molecular Biology;molecular imaging;Mus;Muscle;Muscle Cells;Myocardial;myocardial injury;Myocardial tissue;Myocardium;Natural regeneration;Neonatal;novel;Optics;overexpression;Patients;Periodicity;Pilot Projects;porcine model;postnatal;prevent;Proliferating;promoter;Protocols documentation;Public Health;Recovery;regeneration potential;Regimen;Regulatory Pathway;repaired;Reporting;restoration;RNA;RNA delivery;Rodent Model;Signal Pathway;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;Smooth Muscle Myocytes;Stretching;success;Surface;synergism;Techniques;Technology;Testing;Therapeutic;Thick;Tissue Engineering;Tissues;transcriptome sequencing;Transplantation;Vascularization;Ventricular;Ventricular Arrhythmia

PROJECT_TITLE: Project 1 - Endogenous and Exogenous Mechanisms that Promote Myocardial Remuscularization


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

PHR: NARRATIVE Cardiovascular disease is common and deadly. The long term goal and the clinical significance of this revised Project 2 proposal are to define the factors that promote heart cells to divide, repair and regenerate the injured heart. The results from these studies will serve as an important platform to enhance future therapeutic initiatives aimed at heart regeneration.

PI_NAMEs: GARRY, DANIEL J. (contact)

PROJECT_TERMS: Adult;Algorithms;angiogenesis;Animal Model;Applications Grants;Bioinformatics;Birth;Blood Vessels;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;Cardiovascular Diseases;Cardiovascular system;Cell Proliferation;Clinical Research;clinically significant;Collaborations;Complement;congenital heart abnormality;Data;Development;Dissection;Endothelium;Engineering;experimental study;Family suidae;Future;Gene Expression;Genetic;Genetic Engineering;Genetic Models;Goals;Growth;Heart;heart cell;Heart Diseases;Heart failure;Heart Injuries;In Vitro;injured;Injury;innovation;Ischemia;Knock-out;Laboratories;Lower Organism;Messenger RNA;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Myocardial Infarction;myocardial injury;Natural regeneration;Neonatal;Newts;novel;novel therapeutics;overexpression;Pathway interactions;Patient Care;Patients;porcine model;postnatal;pre-clinical;programs;Proliferating;Publications;Publishing;Regenerative capacity;repaired;Role;Signal Pathway;Societies;SOX4 gene;synergism;Techniques;Technology;Testing;Therapeutic;Tissues;tool;Ventricular;Viral Vector

PROJECT_TITLE: Project 2 - Shh and Etv2 Signaling Pathways and Cardiovascular Repair in Mouse and Pig


PHR: NARRATIVE  (Project 3) Role of Proline Metabolism in Regulation of Mammalian Cardiomyocyte Proliferation This project will determine the role of metabolic adaptation to hypoxia in regulation of cardiomyocyte proliferation and heart regeneration in mice and pigs.

PI_NAMEs: SADEK, HESHAM  (contact)

PROJECT_TERMS: Adult;Biological Process;Birth;Cardiac Myocytes;cardiac regeneration;Cell Cycle;Cell Cycle Arrest;Cell Cycle Regulation;Cessation of life;Chronic;Citric Acid Cycle;Competence;Complex;Cytoplasm;Data;DNA Damage;environmental change;enzyme pathway;Enzymes;Exposure to;Failure;Family suidae;gain of function;Genetic;Heart;Heart failure;Hypoxia;Hypoxia Inducible Factor;inhibitor;Injury;loss of function;Malate-Aspartate Shuttle Pathway;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;mitochondrial metabolism;Modeling;Molecular;mouse model;Mus;Muscle;Muscle Cells;Myocardial;myocardial hypoxia;NADP;Natural regeneration;Neonatal;Newborn Infant;Oxidation-Reduction;Oxidative Phosphorylation;Oxygen;Physiological;Population;porcine model;postnatal;Process;Proliferating;Proline;Proline Dehydrogenase;Proteomics;regenerative;Regenerative capacity;Regulation;Reporting;Respiration;response;response to injury;Role;Signal Transduction;Source;Testing;Transcriptional Regulation;transcriptomics;Ventricular

PROJECT_TITLE: Project 3 - Role of Proline Metabolism in Regulation of Mammalian Cardiomyocyte Proliferation


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Services;Kidney Disease;Palliative Care;Wound Healing and Care

ORG_CITY: GAINESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Patients living with both advanced peripheral arterial disease (“critical limb ischemia”) and end-stage renal disease have high rates of mortality and limb loss. Patients with both conditions are common, treatments are resource-intensive, and decision-making is nuanced and yet there are no rigorous data on outcomes and no guidelines on care. This project aims to determine national treatment outcomes and factors affecting treatment selection, and to help create clinical care guidelines and identify research priorities.

PI_NAMEs: SHAH, SAMIR KAUSHIK (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: accountable care organization;Affect;Aftercare;American;Amputation;beneficiary;Biology;Blood Vessels;Bypass;Cardiology;Cardiovascular system;care outcomes;career;career development;Caring;Catheters;clinical care;Clinical Research;college;comorbidity;Complement 3;Conflict (Psychology);critical limb Ischemia;Data;Death Rate;Decision Aid;Decision Making;Development;Diagnosis;Dialysis procedure;Disease;End stage renal failure;Environment;experience;Fee-for-Service Plans;Florida;follow-up;Foundations;Gangrene;Geography;Goals;Grant;Guidelines;Health Personnel;Health Services Research;Hemodialysis;Hospital Referrals;improved;Incidence;Intervention;Kidney Failure;Knowledge;large datasets;Leadership;Learning;Length of Stay;Life;limb loss;Limb structure;Literature;Managed Care;Medicare;Medicare claim;Medicine;Mentors;Mentorship;Methods;Morbidity - disease rate;mortality;multidisciplinary;Nephrology;non-healing wounds;Operative Surgical Procedures;Outcome;Outcomes Research;Pain;Pain management;Patient-Centered Care;Patient-Focused Outcomes;Patients;Peripheral arterial disease;Persons;Physicians;Population;Population Heterogeneity;Positioning Attribute;preference;Procedures;Process;programs;Provider;Recommendation;Research;Research Personnel;Research Priority;Resources;Rest;Risk Factors;risk sharing;Sample Size;satisfaction;Selection for Treatments;shared decision making;skill acquisition;skills;Societies;Stents;Symptoms;Techniques;Training;treatment as usual;treatment choice;Treatment Factor;Treatment outcome;Universities;Vascular Diseases;wound care;Writing

PROJECT_TITLE: Outcomes and perspectives on treatment for critical limb ischemia in patients with end-stage renal disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE We propose to identify needed chemical probes as well as potential prototype drugs that inhibit the exonuclease 1 (EXO1) enzyme involved in DNA repair. A novel EXO1 inhibitor will allow us to provide a critical tool to test how DNA repair works inside normal and cancerous cells, and will also help towards the development of a new drug that blocks these pathways in cancer cells. This will be important for studying and treating breast cancer and other cancers in which these pathways are altered.

PI_NAMEs: HORNE, DAVID A.;SHEN, BINGHUI  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: absorption;analog;anti-cancer therapeutic;Benchmarking;Binding;Biochemical;Biological;Biological Assay;Biological Process;brca gene;BRCA1 gene;Breast;Breast Cancer Cell;Breast Cancer Treatment;cancer cell;Cancer Etiology;Cancerous;Catalogs;Cell Death;Cell Physiology;Cells;Chemicals;cheminformatics;Clinical;Collaborations;Core Facility;counterscreen;Critical Pathways;cytotoxic;cytotoxicity;Dedications;Development;DNA;DNA biosynthesis;DNA Damage;DNA redundancy;DNA Repair;DNA Repair Enzymes;DNA replication fork;Dose;Drug Kinetics;druggable target;Enzyme Inhibition;Enzymes;Excision;Exclusion;Excretory function;EXO1 gene;exodeoxyribonuclease;Exonuclease;Failure;Family member;Fluorescence;Fluorescence Resonance Energy Transfer;gene repair;Genes;Genetic;Goals;Growth;high throughput screening;hormone related cancer;Human;Human Cloning;improved;In Vitro;inhibitor;insight;Invaded;Kinetics;Knock-out;Label;Lead;lead optimization;Length;Libraries;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Medical;Medicine;Metabolism;meter;Mutate;Mutation;Normal Cell;novel;novel therapeutics;nuclease;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Positioning Attribute;Powder dose form;pre-clinical;Predisposition;Process;Property;Proteins;prototype;Qualifying;Reaction;repaired;replication stress;Research;response;RNA primers;Rodent;scaffold;scale up;Signal Pathway;Single-Stranded DNA;small molecule;small molecule inhibitor;Specificity;Structure-Activity Relationship;synergism;Testing;Therapeutic;tool;Toxic effect;Validation;Work

PROJECT_TITLE: Identification of small molecule inhibitors to exonuclease 1 for breast cancer treatment

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Liver Disease

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE / RELEVANCE Cell death and inflammation are two central elements in the pathogenesis liver fibrosis, the central process leading to increased morbidity and mortality secondary to liver disease. We have uncovered a novel role of the NLRP3 inflammasome as a modulator of hepatic stellate cell biology, the key liver cell involved in activation of the fibrotic program and liver fibrosis. The studies in this application will focus on targeting novel mechanisms of inflammation, cell death, and fibrogenesis to inhibit or reverse the development of fibrosis in order to prevent morbidity and mortality associated with progressive liver disease.

PI_NAMEs: FELDSTEIN, ARIEL ;HOFFMAN, HAROLD M (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Adaptor Signaling Protein;Address;Apoptosis;Biological Assay;CASP1 gene;Cell Death;Cell membrane;Cell model;Cells;Cellular biology;Cholesterol;Chronic;Collagen;Complex;cytokine;Cytoplasmic Protein;Data;Deposition;Development;Diet;Disease;Elements;experimental study;Fatty acid glycerol esters;fibrogenesis;Fibrosis;Fructose;gain of function mutation;Genetically Engineered Mouse;Goals;healing;Hepatic Stellate Cell;Hepatocyte;Human;IL18 gene;Immune;immune activation;Immunology;In Vitro;in vivo;induced pluripotent stem cell;Infiltration;Inflammasome;Inflammation;Inflammatory;Interleukin-1 beta;Knock-in;Knock-out;Knockout Mice;Kupffer Cells;Liver;liver development;Liver diseases;Liver Fibrosis;liver inflammation;loss of function;LoxP-flanked allele;Macrophage;Mediating;Mediator;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;neutrophil;new therapeutic target;nonalcoholic steatohepatitis;novel;Pathogenesis;Pathway interactions;Pattern recognition receptor;Peptide Hydrolases;Population;Positioning Attribute;prevent;Process;programs;Proteins;Publishing;recruit;response;RNA;Role;Secondary to;Serine Protease;Signal Pathway;Signal Transduction;Sterility;success;Tamoxifen;Testing;Time;tool;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;Western Blotting

PROJECT_TITLE: Sterile inflammation and pyroptotic cell death in liver fibrosis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Dystonia;Estrogen;Neurodegenerative;Neurosciences;Rare Diseases;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: The proposed experiments will not only define the molecular and physiological signatures of dystonia but will do so in context of biological sex, a known risk factor for the disorder but one that is largely unexplored. Understanding and recognizing sex differences in the pathomechanisms of dystonia will provide a foundation that is critical for optimizing diagnoses, targeting treatments, and designing clinical trials.

PI_NAMEs: HESS, ELLEN J. (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Affinity Chromatography;Animal Model;Basal Ganglia;biological sex;cell type;Clinical Trials Design;Code;Corpus striatum structure;Data;Diagnosis;Disease;Dopa-Responsive Dystonia;Dopamine;Dystonia;epidemiology study;Estradiol;Estrogens;Estrous Cycle;Estrus;experimental study;Female;Fibrinogen;Foundations;Functional disorder;Functional Imaging;Genes;Globus Pallidus;Hormonal;Human;Hyperactivity;Image;imaging study;in vivo;Knock-in Mouse;Knowledge;male;Mediating;Microelectrodes;Molecular;Molecular Profiling;mouse model;Movement;Movement Disorders;Mus;Muscle Contraction;Mutation;neural;Neurons;neuroregulation;neurotransmission;Ovarian hormone;Ovariectomy;Pathogenesis;Pathway interactions;Patients;Pattern;Phase;Physiological;Physiology;Play;Posture;Process;Property;prototype;Ribosomes;Risk Factors;Role;Sample Size;segregation;sex as a biological variable;Sex Bias;sex cycle;Sex Differences;sexual dimorphism;Smooth Muscle;Structure;Substantia nigra structure;Testing;Time;Tissues;Translating;translatome

PROJECT_TITLE: Neuronal Mechanisms underlying sex differences in dystonia

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]