NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Maternal Health;Neurosciences;Nutrition;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE Iodine deficiency is one of the most common and preventable causes of neurodevelopmental impairment worldwide. In a randomized controlled trial of high-fidelity, iodized salt provision along the continuum of pregnancy and lactation, we will determine the effects of iodine on early human brain development utilizing novel, multi-modal measures of neural function. This study will generate foundational knowledge about the role of iodine in the first 1000 days of life and inform the design and delivery of interventions to optimize the potential of children worldwide.

PI_NAMEs: CHERKERZIAN, SARA  (contact);LEE, ANNE SHEE CC

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;adverse birth outcomes;Age Months;Alberta province;antenatal;arm;Award;behavior measurement;Behavioral;Birth;Blood;Brain;Child;Childhood;cost efficient;Counseling;design;Development;Dietary intake;dietary requirement;early pregnancy;Electroencephalography;Electrophysiology (science);Ethiopia;Feeding Patterns;Ferritin;fetal;Food;Foundations;Funding;General Population;Goals;Grant;group intervention;Head circumference;Human;Human Milk;improved;Infant;Infection;Infection Control;Infectious Pregnancy Complications;Intervention;intervention delivery;intervention effect;Iodine;iodine deficiency syndrome;iodized salt;Iron;Knowledge;Lactation;Language;Life;Measures;Memory;Mothers;Motor;multimodality;myelination;National Institute of Child Health and Human Development;neural;Neurocognitive Deficit;neurodevelopment;Neurodevelopmental Impairment;Neurophysiology - biologic function;novel;nutrition;Outcome;Parents;Pattern;Play;Population;Postpartum Period;Pregnancy;pregnant;Pregnant Women;Prenatal Nutrition;primary outcome;Randomized;Randomized, Controlled Trials;Research;response;Role;Rural;Selenium;Sodium Chloride;Spottings;standard care;Supplementation;Testing;TFRC gene;Third Pregnancy Trimester;Thyroglobulin;Thyroid Function Tests;Thyroid Hormones;Thyrotropin;Thyroxine;Urine;Variant;Visual attention;Visual evoked cortical potential;Woman

PROJECT_TITLE: Effect of iodized salt in pregnancy and lactation on infant neurodevelopment in rural Ethiopia

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: WALTHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: This Core Center of Excellence (P30) application for the renewal of the Brandeis/Harvard Center to Improve System Performance of Substance Use Disorder Treatment proposes to conduct and extend research on SUD service delivery and payment methods to synergistically expand the research base – serving as a national resource to inform research as well as policy and practice decisions that will profoundly affect the cost, quality, equity and availability of SUD treatment services – and supporting early career investigators in addiction health services research. The Center fills a critical public health need to better understand how to improve performance of the SUD treatment system.

PI_NAMEs: HUSKAMP, HAIDEN A.;REIF, SHARON  (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Accident and Emergency department;addiction;Affect;American;Attention;base;beneficiary;bundled payment;career;Clinic;Collaborations;cost;Decision Making;design;Development;Effectiveness;Enrollment;Environment;Equity;ethnic diversity;Fertilization;Goals;Health;health plan;Health Services Research;Healthcare Systems;Improve Access;improved;Individual;Inequity;innovation;integrated care;Interdisciplinary Study;Joints;Knowledge;Leadership;Learning;lens;Lived experience;Managed Care;Managed Care Programs;Measurement;Medicaid;medical specialties;Mentors;Methods;Modeling;multidisciplinary;Nature;next generation;opioid use disorder;Paper;patient oriented;payment;Performance;Persons;Pharmaceutical Preparations;Pharmacy facility;Policies;Policy Maker;Policy Making;Primary Care;Private Sector;Privatization;Process;programs;Provider;Public Health;Quality of Care;racial diversity;Research;Research Personnel;Research Project Grants;Resources;Role;Science;service delivery;Services;Site;Stretching;Substance Use Disorder;System;telehealth;Time;Training;Translating;treatment services;Work


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

PI_NAMEs: REIF, SHARON  (contact)

PROJECT_TERMS: Academia;addiction;Agreement;Archives;Collaborations;Communication;Communities;data resource;Development;Educational workshop;Ensure;Evaluation;Health Services Research;improved;innovation;insight;Institution;knowledge translation;Lead;Leadership;Lived experience;medical schools;member;Mentors;Methods;Monitor;multidisciplinary;next generation;Office of Administrative Management;outreach;Paper;patient oriented;payment;Performance;Persons;Policies;Policy Maker;Positioning Attribute;Productivity;Provider;Research;Research Personnel;Research Project Grants;Resource Allocation;Resources;Role;Science;service delivery;Structure;Substance Use Disorder;success;symposium;synergism;System;Techniques;Training;Training Activity;Translations;Universities;Vision;webinar

PROJECT_TITLE: Administrative Core - Supporting the National Center of Excellence


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Substance Misuse

PI_NAMEs: STEWART, MAUREEN T (contact)

PROJECT_TERMS: addiction;Address;analytical method;Area;Award;career;Collaborations;design;Development;doctoral student;early-career faculty;Education;Educational workshop;Elements;ethnic diversity;ethnic minority;Ethnic Population;experience;Faculty;Funding;Goals;graduate student;Grant;Health Services;Health Services Research;Home;implementation research;implementation science;improved;Individual;Information Centers;innovation;Institution;interest;K-Series Research Career Programs;Learning;Link;member;Mentors;Mentorship;Methods;Mission;National Institute of Mental Health;National Institute on Alcohol Abuse and Alcoholism;next generation;outreach;Paper;payment;Performance;Postdoctoral Fellow;programs;Race;racial diversity;racial minority;racial population;Research;Research Design;Research Institute;Research Personnel;Scholars Program;Science;Scientist;service delivery;Services;Structure;Students;Substance Use Disorder;success;symposium;System;Training;Training Programs;treatment services;Underrepresented Populations;Universities;Washington;webinar;Work;Writing

PROJECT_TITLE: Advancing the Next Generation: Mentoring and Pilot Papers


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Long-term maintenance of regular physical activity significantly lowers risks of cancer and chronic diseases. Public health guidelines recommend combinations of activity intensity, frequency, and duration to achieve a “dose” of at least 150 min/week of moderate-to-vigorous intensity physical activity. While this approach aims to produce measurable health benefits, it fails to address emotional experiences (i.e., how people feel) during behavior, which may contribute to long-term sustainability. This early-phase trial will test intervention strategies to influence affective mechanisms underlying physical activity and determine whether changes in those mechanisms result in change in physical activity behavior among inactive adults who are overweight or obese.

PI_NAMEs: DUNTON, GENEVIEVE FRIDLUND (contact)

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Address;Adherence;Adult;Affect;Affective;American;Behavior;behavior influence;Behavior Therapy;behavioral health intervention;Behavioral Sciences;Body Weight;Body Weight decreased;cancer risk;Charge;Chronic Disease;Clinical;coping;Crossover Design;Data;design;Development;Devices;Dose;early phase trial;Ecological momentary assessment;efficacy trial;emotional experience;evidence base;experience;Feeling;fitness;Food;Frequencies;Future;Goals;Guidelines;Health;Health Benefit;Heart Rate;incentive salience;Individual;Informal Social Control;insight;interest;Intervention;intervention effect;Life;Maintenance;Malignant Neoplasms;Measurable;Measures;Mediating;Mediator;Medicine;Methods;mobile computing;Monitor;mortality;Motivation;Obesity;Overweight;Pain;Pathway interactions;Persons;phase I trial;Physical activity;physical inactivity;pleasure;positive emotional state;primary outcome;Process;psychologic;Public Health;Randomized;Recommendation;Research;response;secondary outcome;Self Efficacy;Self-control as a personality trait;Stress;Testing;theories;Time;Translating;Translations;treatment effect;treatment optimization;vigorous intensity

PROJECT_TITLE: Using real-time data capture to examine affective mechanisms as mediators of physical activity adherence in interventions

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Cancer;Clinical Research;Digestive Diseases;Immunization;Immunotherapy;Inflammatory Bowel Disease;Lung;Skin Cancer

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: This proposed project promises to contribute significantly to the growing field of immuno-oncology by providing insights into a novel mechanism contributing to the development of immune-related adverse events (irAEs). In doing so, this work will lay the foundation for the development of a novel therapeutic strategy to suppress the side-effects associated with checkpoint inhibitor immunotherapies while also establishing previously unknown candidate biomarkers for predicting the development of these irAEs in cancer patients.

PI_NAMEs: HANKS, BRENT ALLEN (contact)

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: Address;Adjuvant;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;antibody immunotherapy;Antibody Therapy;Arthritis;biomarker development;Cancer Patient;cancer type;candidate marker;CD8-Positive T-Lymphocytes;chemokine;Chronic;Clinical Management;Clinical Oncology;Clinical Research;Colitis;Colon;Combination immunotherapy;Data;design;Development;Distant;Engineering;Foundations;Future;Generations;Genetic;Genetic Engineering;Genetic Variation;Germ Lines;Heat-Shock Proteins 70;Human;IL8RB gene;Immune;Immune checkpoint inhibitor;Immune response;immune-related adverse events;immunomodulatory therapies;Immunooncology;Immunotherapeutic agent;Immunotherapy;improved;Incidence;Individual;Inflammasome;Inflammatory;inhibitor;inhibitor therapy;Innate Immune System;insight;Institutional Review Boards;Investigation;ipilimumab;Knock-out;Lamina Propria;Link;Lung;Mediating;Melanoma;Melanoma patient;Modality;Modeling;Mus;Mutation;neutrophil;Neutrophil Infiltration;Nivolumab;novel;novel therapeutic intervention;Organ;Outcome;Pathogenesis;Pathology;Pathway interactions;Patients;PD-1 blockade;pharmacologic;Plasma;Prediction of Response to Therapy;predictive marker;Prevalence;programmed cell death ligand 1;Protocols documentation;Pulmonary Inflammation;Quality of life;Recurrence;Regimen;Reproducibility;response;Role;side effect;Signal Transduction;small molecule inhibitor;Specimen;Steroid Resistance;Steroids;Structure of parenchyma of lung;success;Therapeutic;Tissue Harvesting;Tissues;TLR4 gene;Toxic effect;Transgenic Model;Transgenic Organisms;treatment strategy;tumor;tumor ablation;tumor DNA;Tumor Tissue;Work

PROJECT_TITLE: Role of the tumor NLRP3 inflammasome in the generation of anti-PD-1 antibody immunotherapy-associated toxicities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Clinical Research;Disability Research;Machine Learning and Artificial Intelligence;Osteoarthritis;Physical Injury - Accidents and Adverse Effects

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Osteoarthritis remains the leading cause of disability, and effective treatment will require efﬁcient assessment of disease risk-factors, onset, and progression, both for development and personalization of minimally invasive interventions. We propose a 5-minute 3D MRI exam of both knees without radiation or contrast injection, that will be combined with low-cost measures of knee motion and fully automated analysis methods to provide quan- titative measurements of cartilage, tendon, ligament, bone and ﬁbrocartilage health and asymmetries between knees. This low-cost, rapid, bilateral assessment will enable research studies in large populations, as well as adding quantitative bilateral information to clinical scans to dramatically improve understanding of onset of dif- ferent types of osteoarthritis.

PI_NAMEs: HARGREAVES, BRIAN ANDREW (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Affect;American;analysis pipeline;Anterior Cruciate Ligament;anterior cruciate ligament injury;anterior cruciate ligament rupture;Articulation;automated analysis;Bilateral;Biochemical;biomechanical test;Biomechanics;bone;Bone Marrow;Bone Spur;Cartilage;Chronic;Clinical;Cluster Analysis;cohort;Collaborations;Connective Tissue;cost;Cost Measures;Coupled;Data;Data Pooling;deep learning;Degenerative polyarthritis;density;Detection;Development;Diagnosis;Diagnostic;Diffusion;Diffusion Magnetic Resonance Imaging;disability;Disability treatment;Disease;disease phenotype;disorder risk;early onset;effective therapy;Enrollment;Environment;Equipment;Etiology;Evaluation;Female;Femur;Fibrocartilages;Future;Gait;Gait abnormality;gait examination;Goals;Health;high body mass index;Human Resources;Image;image reconstruction;improved;Inflammatory;Injections;Injury;Intervention;Joints;Kellgren-Lawrence grade;kinematics;Knee;Knee Osteoarthritis;learning classifier;Left;Length;Lesion;Ligaments;Magnetic Resonance Imaging;Manuals;Maps;Measurement;Measures;meniscus injury;Meniscus structure of joint;Methods;minimally invasive;Morphology;Motion;Motivation;novel;Orthopedics;Output;Pain;Patient Triage;Patients;Population;primary outcome;Protocols documentation;Protons;Quality of life;Quantitative Evaluations;quantitative imaging;Radiation;radiological imaging;Reader;reconstruction;Replacement Arthroplasty;Research;Research Personnel;research study;Risk;Risk Factors;Roentgen Rays;Sampling;Scanning;sensor;Sex Differences;skills;Slice;societal costs;Structure;Surface;Synovitis;Techniques;Tendon structure;Testing;therapy development;Thick;Time;tissue biomarkers;Tissues;Traumatic Arthropathy;ultra high resolution;Visualization

PROJECT_TITLE: Rapid Low-Cost Quantitative 3D MRI and Gait Assessment of the Knee

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: San Diego

ORG_NAME: TING THERAPEUTICS, INC.

PHR: PROJECT NARRATIVE The work in this proposal focuses on further preclinical development of TT002 to protect from cisplatin-induced hearing loss. If successful, this proposal will allow Ting Therapeutics to initiate conversations with pharmaceutical companies for the manufacturing and commercialization of TT002 and for IND-approval by the FDA for its use as a standard otoprotective component of cisplatin-based therapies.

PI_NAMEs: HUANG, YUNLONG  (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Adult;Aftercare;Animal Model;Animals;Anthelmintics;anticancer activity;Antineoplastic Agents;Antioxidants;Attenuated;Audiology;Auditory;Auditory Brainstem Responses;authority;Benchmarking;Blood;Cancer cell line;Cancer Patient;Cavia;Cell Line;Cestoda;Chemicals;chemotherapy;Cisplatin;cisplatin induced hearing loss;Clinical;Clinical Treatment;Clinical Trials;Cochlea;commercial application;commercialization;Contracts;Data;design;Detection;Dose;Drug Interactions;Drug Kinetics;Drug Screening;drug testing;Drug usage;efficacy study;experimental study;FDA approved;Food and Drug Administration Drug Approval;Freedom;Future;FVB Mouse;Germany;Glutathione Metabolism Pathway;Goals;good laboratory practice;guinea pig model;Hair Cells;healthy volunteer;hearing impairment;hearing preservation;Hearing Protection;Human;Immunohistochemistry;in silico;In Vitro;in vitro activity;in vivo;International;intraperitoneal;Investigational Drugs;Investments;Knowledge;Labyrinth;Legal patent;Liquid Chromatography;Malignant neoplasm of testis;Malignant Neoplasms;manufacture;Measures;Morphology;mouse model;Mus;neoplastic cell;New Drug Approvals;novel therapeutics;Observational Study;Oral Administration;otoacoustic emission;otoprotectant;ototoxicity;Outcome;Patients;Performance;Perilymph;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacologic Substance;Phase;phase 1 study;preclinical development;preclinical evaluation;preclinical study;preclinical trial;prevent;prevent hearing loss;Procedures;Protocols documentation;Publishing;Quality of life;Regimen;research clinical testing;Research Contracts;Rights;Rodent Model;Safety;safety and feasibility;Small Business Innovation Research Grant;Sodium Chloride;sodium thiosulfate;technological innovation;Testing;Therapeutic;Therapeutic Index;Time;Toxic effect;Toxicology;Treaty;tumor;tumor xenograft;United States Food and Drug Administration;virtual;vitamin metabolism;webinar;Western Blotting;Work;Xenograft Model;Zebrafish

PROJECT_TITLE: Preclinical evaluation of an otoprotectant TT002


ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Cisplatin-based combination chemotherapy is the standard-of-care treatment for muscle invasive bladder cancer but 70% of patients do not respond. We discovered a novel mechanism by which puromycin-sensitive aminopeptidase, NPEPPS, is upregulated, and we have strong evidence supporting its interaction with volume- regulated anion channels (VRACs) to block import of cisplatin and other platins into cancer cells. The focus of this proposal is to characterize this novel mechanism and evaluate pharmacological inhibition of NPEPPS in combination with platin drugs in preclinical models with the objective of eventually improving patient outcomes.

PI_NAMEs: COSTELLO, JAMES CHRISTOPHER;THEODORESCU, DAN  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Adjuvant Chemotherapy;Affect;Aminopeptidase;Animal Model;Anions;Antineoplastic Agents;Automobile Driving;Back;Binding;Biochemical;Biological Assay;Biophysics;cancer cell;Cancer cell line;Cancer Model;Cancer Patient;Candidate Disease Gene;Carboplatin;cell growth;Cell Proliferation;Cells;cellular imaging;Chemoresistance;chemotherapy;Chromatin;Cisplatin;Clinical;Combination Drug Therapy;Complex;Coupled;CRISPR screen;CRISPR/Cas technology;Cystectomy;Data;Dependence;design;Disease;Drug resistance;druggable target;Effectiveness;Foundations;Future;Genes;Growth;Human;Impairment;improved;improved outcome;In Vitro;in vivo;inhibitor;Kidney;knock-down;Malignant neoplasm of urinary bladder;Mass Spectrum Analysis;Mediating;Mediator;member;molecular modeling;muscle invasive bladder cancer;mutant;Mutate;Neoadjuvant Therapy;novel;novel strategies;Organoids;Outcome;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Platinum;pre-clinical;Pre-Clinical Model;preclinical evaluation;Prognostic Factor;Prognostic Marker;Proteins;puromycin-sensitive aminopeptidase;reconstitution;Regulation;Residual Neoplasm;Resistance;response;Role;Site;Site-Directed Mutagenesis;standard of care;Testing;therapeutic evaluation;therapeutic target;translational therapeutics;Translations;tumor;tumor growth;Tumor Suppressor Proteins;whole genome

PROJECT_TITLE: NPEPPS is a novel and druggable determinant of chemotherapy resistance in bladder cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative The ultimate goal of the multi-institutional Weill Cornell Clinical and Translational Science Center (CTSC) is to transform the national translational research enterprise to improve human health by supporting high quality clinical and translational research and research training. In the upcoming funding period, the CTSC will, with its partners at Memorial Sloan Kettering Cancer Center, Hospital for Special Surgery, Hunter College, School of Nursing, School of Urban Public Health; of City University of New York), Cornell University at Ithaca and the Animal Medical Center will continue to develop the existing infrastructure and its initiatives, to add new ones, to enhance networking, and to improve diversity, equity, and inclusion. In so doing, we will continue to advance translational science to improve community health, enhancing informatics to improving health inequities, and preparing for health crises, like the COVID-19 pandemic. continuing to develop our highly successful clinical and translational education programs, creating Team Science initiatives that promote inclusion across the CTSC. Project Narrative Page 299

PI_NAMEs: IMPERATO-MCGINLEY, JULIANNE L (contact)

PROGRAM_OFFICER_NAME: NAGEL, JOAN DAVIS

PROJECT_TERMS: Adoption;Animals;Area;Atmosphere;Award;base;Bioinformatics;Biomedical Research;career;career development;Center for Translational Science Activities;Child;Cities;Clinic;Clinical;Clinical Research;Clinical Sciences;clinical translation;Collaborations;collaborative environment;college;Communication;Communities;community engagement;Community Health;Community Networks;community organizations;Community Outreach;community research;Computer software;computing resources;Country;COVID-19 pandemic;design;Development;Device or Instrument Development;disability;Discipline;Disease;Education;Educational process of instructing;Elderly;Ensure;Entrepreneurship;equity, diversity, and inclusion;Ethics;ethnic minority;Fostering;Funding;Future;Future Generations;Generations;Goals;graduate school;hackathon;Health;health disparity;health inequalities;high standard;Home;Hospitals;Human;improved;Informatics;Infrastructure;innovation;Institution;invention;lectures;Medical center;medical schools;Medicine;Memorial Sloan-Kettering Cancer Center;Multi-Institutional Clinical Trial;multidisciplinary;New York;New York City;novel;Operative Surgical Procedures;opioid epidemic;Orthopedics;outreach;pandemic impact;Pathway interactions;Population;precision medicine;Presbyterian Church;Preventive Medicine;Process;Program Development;programs;Public Health;Published Comment;racial minority;Radial;Research;Research Personnel;research study;Research Training;Resources;School Nursing;Science;Self Stimulation;Series;Site;Special Hospitals;Special Population;Strategic Planning;Students;symposium;synergism;System;therapeutic development;TNFSF15 gene;Training;Translating;Translational Research;translational research program;translational study;underserved area;underserved community;Universities;urban public health;urban school;Vaccination;vaccine hesitancy;virtual;Walking;web portal;Work


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative: Overall Impactful biomedical research requires an increasing level of sophistication in data acquisition and analysis. The goal of the Nebraska Center for Molecular Target Discovery and Development is to facilitate biomedical research university-wide by providing mentoring/guidance and underwriting the cost of access to cutting-edge techniques that will catalyze the identification, validation, and development of potential therapies against molecular targets for clinically important diseases.

PI_NAMEs: LEWIS, ROBERT E. (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: analytical method;Appointment;Award;Awareness;Basic Science;Belief;bench to bedside;Biological;Biological Models;Biology;Biomedical Research;Career Mobility;Cells;Centers of Research Excellence;Chemicals;Classification;Clinical;Collaborations;college;cost;Data;data acquisition;Data Analyses;Data Set;Dedications;Development;Discipline;Disease;Evaluation;expectation;experience;Faculty;faculty support;Financial Support;Funding;Future;Generations;genetic analysis;Genomics;Goals;Grant;Health;Homeostasis;Human;improved;Infrastructure;inhibitor;insight;Institution;interest;Investments;Journals;Medical center;member;Mentors;Modernization;Molecular;Molecular Analysis;Molecular Target;Nebraska;novel;novel therapeutics;operation;Organoids;Phase;Pre-Clinical Model;preclinical development;programs;Protac;Reagent;Research;research and development;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;skill acquisition;small molecule;success;System;Taxes;Teacher Professional Development;Techniques;Technology;technology development;Therapeutic;therapeutic development;therapeutic target;Time;Training;transcriptomics;undergraduate student;Universities;Validation;Vision


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Acceleration;Advisory Committees;Biology;Biotechnology;career;career development;Certification;Clinical;cohort;Communication;Complex;Creativeness;Data Analyses;Dedications;design;Detection;Development;Development Plans;Disease;doctoral student;Drug Industry;Effectiveness;Ensure;Environment;Etiology;experience;Experimental Designs;experimental study;Faculty;Fostering;Funding;Generations;Goals;Grant;Health;Human;human disease;improved;Infrastructure;innovation;interest;Investments;knowledge translation;Laboratories;Lead;Leadership;meetings;member;Mentors;Mission;Molecular;Molecular Target;Nebraska;novel strategies;Outcome;Performance;Pilot Projects;Postdoctoral Fellow;Pre-Clinical Model;Procedures;Program Research Project Grants;programs;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;Scientist;Secure;senior faculty;Series;skills;small molecule;System;Talents;Teacher Professional Development;tool;Training;Universities;Update;Validation;voucher;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Estrogen;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Social Determinants of Health;Women's Health Research

ORG_CITY: BLOOMINGTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: NARRATIVE Sex and gender disparities in the severity and frequency of asthma exacerbations have been extensively reported, yet the biological and hormonal basis of these differences have not been elucidated. Here, we investigate the mechanisms by which estrogen triggers inflammation in the male and female asthmatic lung. Our findings will determine the molecular basis of hormonal triggers of asthma exacerbations in cis and transgender women and lead to the future development of better personalized therapeutic options for lung disease.

PI_NAMEs: SILVEYRA, PATRICIA  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Accounting;Adult;Adult women;Affect;Agonist;Air Movements;Air Pollution;airway hyperresponsiveness;airway obstruction;Allergens;antagonist;Asthma;asthma exacerbation;asthma model;asthma prevention;asthmatic;asthmatic patient;Automobile Driving;Award;Binding;Biological;bronchial epithelium;Cells;cis-female;cost;cytokine;Data;Development;Diagnosis;differential expression;Disease;Disparity;dosage;Environmental Exposure;Environmental Risk Factor;Epithelial Cells;Estradiol;Estrogen Receptors;Estrogens;Estrous Cycle;Experimental Models;experimental study;Exposure to;Female;female sex hormone;Feminization;Four Core Genotypes;Frequencies;Future;Gender;gender difference;gender disparity;Gene Expression;Genes;Genomics;Goals;Gonadal Hormones;Gonadal Steroid Hormones;GPER gene;Health;Hormonal;hormone therapy;Hormones;Hospitalization;House mice;Human;Incidence;Individual;Individual Differences;Inflammation;Inflammatory;Inflammatory Response;Knockout Mice;Knowledge;Laboratories;Life;Liquid substance;Lung;Lung Diseases;male;Measures;Mediating;Mediator;Membrane;men;Menstrual cycle;Menstruation;middle age;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;National Heart, Lung, and Blood Institute;non-genomic;novel therapeutics;Nuclear;Orchiectomy;Outcome;Ovariectomy;Pathway interactions;Patients;personalized therapeutic;Phenotype;Physiological;Ploidies;Population;Prevalence;prevent;Puberty;Public Health;Pulmonary Inflammation;Pyroglyphidae;Receptor Signaling;Recommendation;Recording of previous events;Reporting;Research;Research Priority;respiratory;Respiratory Failure;response;Role;Severities;sex;sex as a biological variable;Sex Chromosomes;Sex Differences;sex disparity;Signal Transduction;Stimulus;Strategic Planning;Structure of parenchyma of lung;Symptoms;Testing;Therapeutic Agents;transgender;transgender women;United States National Institutes of Health;Variant;Woman;Women's Health;Women's Role;women's treatment

PROJECT_TITLE: Gonadal hormones as mediators of sex and gender influences in asthma


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Microbiome

ORG_CITY: PROVIDENCE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Candida albicans is commonly found in the gastrointestinal tract where it is important for stimulation of immune responses, but it can also enter the bloodstream and cause life- threatening systemic infections. This project examines the transcriptional regulation of key cell fate decisions in C. albicans including those controlling filamentation, biofilm formation and phenotypic switching, and also addresses how this regulation contributes to commensal and pathogenic infections.

PI_NAMEs: BENNETT, RICHARD JOHN (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Adopted;Bar Codes;Blood Circulation;Candida;Candida albicans;Cell Fate Control;cell type;Cells;Complex;Cues;Data;Development;Disease;Dissection;Equilibrium;experimental study;Expression Library;Filament;fitness;Foundations;fungus;gastrointestinal;Gastrointestinal tract structure;Gene Expression;Genetic;Genetic Transcription;Genome;high throughput analysis;Human;human microbiota;Immune response;Immunologic Stimulation;In Vitro;in vivo;in vivo evaluation;in vivo Model;Individual;Infection;insight;Kidney;Knowledge;Libraries;Life;Life Style;Liquid substance;macromolecule;Microbe;Microbial Biofilms;Modeling;Molecular;Morphology;mouse model;Mucous Membrane;Mus;mutant;Mutation;new therapeutic target;novel;Oils;Open Reading Frames;opportunistic pathogen;Oral cavity;overexpression;pathobiont;Pathogenesis;Pathogenicity;Phase;Phenotype;Physical condensation;Play;prion-like;Process;programs;promoter;Property;Regulation;response;Role;Skin colonization;Symbiosis;Systemic disease;Systemic infection;Tail;Testing;Therapeutic Intervention;trait;transcription factor;Transcriptional Regulation;urogenital tract;Veins;Water;Yeasts

PROJECT_TITLE: Transcriptional Regulation of C. albicans Cell Fate and Host Interactions

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: HEWITT, KYLE J (contact)

PROJECT_TERMS: Address;analysis pipeline;analytical tool;Area;ATAC-seq;Back;Biological;biomedical informatics;Cell Nucleus;Cell surface;Cells;chromatin immunoprecipitation;Communities;Complex;complex data;Computational Biology;Computer Analysis;Computer software;computerized tools;Consult;Consultations;Core Facility;cost;cost comparison;cyber infrastructure;Data;Data Analyses;Data Set;Detection;Development;differential expression;Disease;Drug Targeting;Effectiveness;Ensure;Equipment;Facility Accesses;Faculty Recruitment;Funding;Future;Gene Expression;Genes;genomic platform;Goals;Grant;Great Plains;Heterogeneity;high throughput analysis;implementation tool;improved;Individual;innovation;insight;instrumentation;Investments;Legal patent;Letters;Libraries;Location;Machine Learning;Maps;Measures;member;Mentors;Messenger RNA;Methods;Microscopy;Mission;Molecular Profiling;molecular subtypes;Molecular Target;multiple omics;Nebraska;new technology;Phase;Positioning Attribute;Postdoctoral Fellow;Preparation;Principal Investigator;Procedures;programs;Protein Secretion;Publications;Quality Control;Reagent;reference genome;Research;Research Personnel;Resolution;Resources;single cell sequencing;single-cell RNA sequencing;skills training;Students;Suspensions;System;Technology;Tissues;tool;Training;Transcript;transcriptomics;Translating;Tumor Subtype;Universities;user-friendly;Validation;Work

PROJECT_TITLE: Single-Cell and Spatial Transcriptomics Core


ORG_CITY: Boulder

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proper spatial and temporal organization of organelles underlies many cellular processes including cell division, migration, differentiation, and communication. Mitochondria are essential organelles that can adapt their morphology and spatial distribution to changing environmental conditions–but the molecular mechanisms governing these physiological processes are still poorly understood, especially in morphologically complex cells like muscles and neurons, which suffer disproportionately from mitochondrial dysfunction during disease- and age-related degeneration. This project will provide fundamental and much-needed knowledge on the molecular mechanisms of regulated mitochondrial morphology for developing a molecular understanding of mitochondrial function in human cells.

PI_NAMEs: AYDIN, HALIL  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: age related;age-related disease;Apoptosis;Architecture;Biochemical Reaction;Bioenergetics;Cardiolipins;Cardiovascular Diseases;catalyst;Cell division;Cell Physiology;Cells;Characteristics;Communication;Complex;Crista ampullaris;Development;Disease;environmental change;Eukaryotic Cell;Guanosine Triphosphate Phosphohydrolases;Human;Impairment;Knowledge;Link;Lipids;Maintenance;Malignant Neoplasms;Membrane;Metabolism;migration;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial Proteins;Molecular;Molecular Abnormality;Morphogenesis;Morphology;Muscle;Neurodegenerative Disorders;Neurons;novel therapeutic intervention;Obesity;OPA1 gene;Organelles;Oxidative Phosphorylation;Pathology;Physiological Processes;Play;Probability;Process;Protein Dynamics;Proteins;Regulation;respiratory;Reticulum;Role;Shapes;Site;Spatial Distribution;Structure;success

PROJECT_TITLE: Regulation of mitochondrial morphology and functional versatility


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Infectious Diseases

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: RELEVANCE The work described in this proposal will elucidate fundamental mechanisms of protein translocation across membranes, the assembly of complex organelles, and virulence factor biogenesis at the bacterial outer membrane. The emergence of multidrug resistant bacteria represents a major health threat, for which new alternatives to traditional antibiotics are urgently needed. This proposal will identify novel anti-virulence compounds that inhibit assembly of adhesive pili by Gram-negative bacterial pathogens, selectively disrupting host-pathogen interactions required to initiate and sustain infection.

PI_NAMEs: THANASSI, DAVID G (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Adhesives;Antibiotic Resistance;Antibiotics;Biochemical;Biogenesis;Biological Models;Bladder;cell envelope;Cell membrane;Cell surface;Cells;combat;Complex;Dedications;Development;Disease;Energy-Generating Resources;Ensure;Escherichia coli;Fiber;Foundations;Funding;Goals;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Hair;Health;healthcare burden;Infection;Kidney;Knowledge;Mediating;Membrane;Membrane Proteins;Microbial Biofilms;Molecular;Molecular Chaperones;molecular dynamics;Molecular Machines;Multiple Bacterial Drug Resistance;Nature;nitazoxanide;novel;novel therapeutics;Organelles;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;periplasm;Pilum;polymerization;Polymers;premature;prevent;protein protein interaction;Protein Secretion;Protein Subunits;Protein translocation;Proteins;prototype;Role;screening;small molecule;small molecule inhibitor;Source;Structure;Surface;System;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Tissues;treatment strategy;Urinary tract infection;Uropathogenic E. coli;Virulence;Virulence Factors;Work

PROJECT_TITLE: Mechanism of the Usher in Assembly and Secretion of Pili

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


PI_NAMEs: BLACK, ADRIAN R (contact)

PROJECT_TERMS: Adoption;Applications Grants;biobank;Biochemical;Biologic Characteristic;Biological Models;Breast;cell type;Centers of Research Excellence;Clinical Data;Colon;Communities;conventional therapy;CRISPR/Cas technology;design;Development;Disease;Drug resistance;drug sensitivity;Drug Targeting;drug testing;Engraftment;experience;experimental study;Funding;genetic manipulation;Genetic Techniques;Goals;Health;Heterogeneity;Histologic;In Situ;In Vitro;in vivo;in vivo evaluation;Individual;Infrastructure;Institutional Review Boards;Knock-out;Laboratories;Liver;Malignant Neoplasms;Mediating;Modeling;Molecular;Molecular Target;Morphology;mouse model;Mus;Nebraska;Normal tissue morphology;Organoids;overexpression;Pancreas;Patients;Pharmaceutical Preparations;Phase;Physiological;Prostate;Protocols documentation;Publications;Reagent;Rectum;repository;Research;Research Personnel;Research Project Grants;Research Subjects;Research Support;Resistance profile;Resources;response;Signal Transduction;Site;small hairpin RNA;Small Intestines;Structure;success;System;targeted treatment;Techniques;Technology;Testing;Time;Tissues;Toxicity Tests;Training;Transfection;tumor;Tumor Tissue;Validation;Xenograft procedure

PROJECT_TITLE: Organoids Core


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project narrative Interleukin 33 (IL-33) is a unique member of the IL-1 superfamily of cytokines that regulate innate and adaptive immunity against gastrointestinal pathogens. IL-33 serves as both a pro- and anti-inflammatory mediator of host protective immunity, but the mechanisms responsible remain unclear. This project will investigate the hypothesis that cellular source of IL-33 is a critical determinant in host protective immunity against helminth and protozoan pathogens.

PI_NAMEs: HERBERT, DE'BROSKI R (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acute;adaptive immunity;Anti-Inflammatory Agents;Antigen-Presenting Cells;Automobile Driving;B-Lymphocytes;Biological;Cell Lineage;Cell Shape;Cells;Chronic;confocal imaging;Confocal Microscopy;Cre driver;cytokine;Data;Defect;Dendritic Cells;Development;Disease;dysbiosis;Epithelial Cells;Epithelium;Equilibrium;experimental study;FOXP3 gene;gastrointestinal;Gastrointestinal tract structure;GATA3 gene;Gene Expression Profile;Genetic Transcription;gut microbiota;helminth infection;Helminths;Homeostasis;Human;IL17 gene;Ileitis;Immune;Immunity;immunopathology;Immunosuppression;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Interferon Type II;Interleukin-1;Interleukins;intestinal crypt;intestinal epithelium;intestinal homeostasis;Intestines;Lymphocyte Subset;Lymphoid;Lymphoid Cell;Macrophage;Maintenance;mass spectrometric imaging;member;microbial;Microscopy;Mus;Myelogenous;Natural Immunity;Natural regeneration;Oral;Organ;Orphan;Outcome;Parasite Control;Parasitic infection;pathogen;Pathogenicity;Pathologic;Population;Predisposition;Production;Protozoan Infections;PTPNS1 gene;Publishing;receptor;Regulation;Regulatory T-Lymphocyte;Reporting;residence;Resistance;response;Retinoic Acid Receptor;Role;Source;T cell response;T-Lymphocyte Subsets;Testing;Therapeutic;tissue repair;Tissues;Toxoplasma gondii;Toxoplasmosis;transcription factor;transcriptome sequencing;vaccination strategy;XCR1 gene

PROJECT_TITLE: Myeloid derived IL-33 controls Treg responses during parasite infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Genetics

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Histone dependent gene regulation is frequently dysregulated in disease. We have identified a novel histone H3 modification and pathogenic H3 variants that modulate proximal histone modification and alter gene expression, and propose to investigate their molecular mechanisms of action. These studies will advance our understanding of how histone-dependent gene expression governs functional biological changes that may underlie human disease.

PI_NAMEs: SPANGLE, JENNIFER MARIE (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acetylation;Amino Acids;Architecture;Biochemical;Biological;Cell Physiology;Chromatin;combinatorial;Competence;Complex;Computing Methodologies;Cues;Data;Deacetylation;Disease;DNA Repair;epigenome;exosome;experience;Gene Expression;Gene Expression Regulation;Genetic;Genetic Transcription;Genome;Histone Acetylation;Histone H3;histone modification;Histones;human disease;Laboratories;Lysine;Malignant Neoplasms;Methylation;Methyltransferase;Modification;Molecular;Molecular Mechanisms of Action;N-terminal;novel;Nucleosomes;Output;Pathogenicity;Pathologic;Pattern;Phosphorylation;Post-Translational Protein Processing;Production;programs;Proteins;Regulation;Research;RNA;RNA Processing;RNA Splicing;Role;Series;Signal Transduction;Structure;Threonine;Transcriptional Regulation;upstream kinase;Variant

PROJECT_TITLE: Role of novel histone modifications and variants in transcriptional regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics

PI_NAMEs: NATARAJAN, AMARNATH (AMAR)  (contact)

PROJECT_TERMS: Address;Adrenal Glands;Alkynes;Alleles;Amino Acid Sequence;analog;assay development;Binding;Binding Sites;Biological;Biology;Biotin;Biotinylation;cancer biomarkers;CDK4 gene;CDK5 gene;Cells;Centers of Research Excellence;chemical genetics;chemical synthesis;Chemicals;Chemistry;Colorectal Cancer;Communities;Complex;Coupled;Data;design;Development;differential expression;DNA lesion;DNA Sequence;drug discovery;Drug resistance;Drug Targeting;Environment;Evaluation;Excision;experience;Experimental Genetics;experimental study;Faculty Recruitment;FDA approved;functional group;Funding;Future;Genetic;Genetic Code;Glycolysis;Grant;in vivo;inhibitor;instrumentation;interest;Kinetics;lead optimization;Legal patent;Libraries;Lysine;Maps;Mass Spectrum Analysis;medullary thyroid carcinoma;member;Methods;Mission;Modification;Molecular;Molecular Target;multicatalytic endopeptidase complex;Mutate;Nebraska;neuroendocrine cancer;Neurologic;neuropsychiatry;novel;Nucleic Acids;Organoids;p53-binding protein 1;Pathway Analysis;Phosphorylation;Phosphotransferases;Post-Translational Protein Processing;pre-clinical;programs;Protac;Protein Analysis;protein degradation;protein function;protein protein interaction;Proteins;Proteome;Proteomics;Publications;Recombinant Proteins;recruit;Regulation;Research;Research Personnel;Research Project Grants;resistance mechanism;RNA Sequences;Role;scaffold;scale up;Scientist;Services;Signal Pathway;Signal Transduction;Signaling Molecule;Site;small molecule;small molecule libraries;spatiotemporal;Structure;Structure-Activity Relationship;System;T-Lymphocyte;Technology;Therapeutic;therapeutic development;therapeutic target;Time;Tissues;tool;treatment response;Ubiquitin;ubiquitin-protein ligase;Universities;Validation

PROJECT_TITLE: Probes, Inhibitors, and PROTACs (PIP) Core


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE: OVERALL COMPONENT: Innovations for screening and prognosis in HIV+ cancers including Kaposi sarcoma, cervical cancer, and lymphoma in Malawi and South Africa In response to RFA-CA-20-001, this application proposes to establish the UNC-Malawi-South Africa Cancer Consortium (UMSACC), to develop capacity and conduct high-impact research focused on HIV-associated cancers. Our consortium will be led by principal investigators with highly complementary expertise using a team science approach and a high priority of the consortium is the training and support of junior investigators in the U.S. and Africa. UMSACC proposes innovations for screening and prognosis of Kaposi sarcoma, cervical cancer and lymphoma in persons living with HIV (PLWH) with the overall goal being to improve the health of PLWH.

PI_NAMEs: CHIBWESHA, CARLA J;DAMANIA, BLOSSOM A (contact);DITTMER, DIRK P;FEDORIW, YURI ;HUWA, JACQUELINE ;RUFF, PAUL

PROGRAM_OFFICER_NAME: DOMINGUEZ, GERALDINA

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Address;Africa;Africa South of the Sahara;AIDS clinical trial group;AIDS Malignancy Consortium;AIDS related cancer;AIDS-Related Lymphoma;anti-cancer research;antiretroviral therapy;Basic Science;Biological Markers;Cancer Burden;Cancer Control;Cancer Prognosis;career;Caring;Clinical Research;clinical research site;Clinical Sciences;Clinical Trials;Collaborations;college;combat;Communicable Diseases;Communities;comorbidity;Comprehensive Cancer Center;Crystallization;Data;data sharing;detection method;Ensure;Epidemic;epidemiology study;Flowers;global health;Goals;Health;high risk;HIV;HIV/AIDS;Hospitals;improved;Individual;Infrastructure;innovation;insight;Institution;International;Kaposi Sarcoma;Knowledge;Leadership;low and middle-income countries;Lymphoma;Malawi;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medicine;Molecular;next generation;North Carolina;oncology program;Patients;Persons;Policies;Population Sciences;Positioning Attribute;Principal Investigator;Prognosis;programs;progression risk;Qualifying;Recurrence;Research;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;response;Science;screening;Site;South Africa;South African;success;Survival Rate;Training;Training and Infrastructure;translational impact;Translational Research;Trust;tumor;UNC Lineberger Comprehensive Cancer Center;United States National Institutes of Health;Universities


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Emerging Infectious Diseases;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE: ADMINISTRATIVE CORE This application responds to RFA-CA-20-001 and will establish a HIV-Associated Malignancy Research Center in the U.S. and Low- and Middle-Income Countries (LMIC) named the UNC-Malawi-South Africa Cancer Consortium (UMSACC). This is a collaborative research center between sites in the USA, Malawi, and South Africa. The Administrative Core will oversee operation, coordination, management, evaluation of projects and cores, and collaborations of the consortium.

PI_NAMEs: DAMANIA, BLOSSOM A (contact)

PROJECT_TERMS: African;AIDS clinical trial group;AIDS Malignancy Consortium;AIDS related cancer;Area;cancer care;Clinical Research;Clinical Trials;Collaborations;Communication;Country;Data;Dedications;Electronic Mail;Evaluation;Flowers;Funding;Goals;Grant;HIV;Hospitals;Human Subject Research;Individual;Infrastructure;innovation;Institution;Kaposi Sarcoma;Leadership;low and middle-income countries;Lymphoma;Malawi;Malignant neoplasm of cervix uteri;Malignant Neoplasms;meetings;member;Names;operation;Prognosis;programs;Progress Reports;Records;Reporting;Research;Research Activity;Research Personnel;Research Support;Resource Sharing;Resources;Schedule;screening;Site;South Africa;success;Training;Trust;Universities;web site;Work


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE: PATHOLOGY CORE The growing focus on personalized medicine requires advanced infrastructure and professional skills, as well as close collaboration between clinicians and pathologists to ensure the accurate prognostication of patients and the selection of targeted therapies for HIV-associated malignancies. This Pathology Core will provide comprehensive diagnostic support to the proposed multi-institutional research projects, build a regional network for high-quality diagnostic services, and establish systems for pathology training and education.

PI_NAMEs: FEDORIW, YURI  (contact)

PROJECT_TERMS: Address;Africa South of the Sahara;AIDS related cancer;anti-cancer research;Area;cancer care;cancer diagnosis;clinical care;Clinical Research;Collaborations;cost effective;Country;Cytology;Data;Development;Diagnosis;Diagnostic;Diagnostic Services;diagnostic tool;Disease;Ensure;Faculty;Foundations;Future;Geographic Locations;Goals;histological specimens;Histology;HIV;Hospitals;Human;improved;Income;Infrastructure;innovation;Institution;Journals;Kaposi Sarcoma;Knowledge;Laboratories;low and middle-income countries;Lymphoma;Malawi;Malignant neoplasm of cervix uteri;Malignant Neoplasms;meetings;Mentors;Multicenter Studies;multidisciplinary;next generation;Pathologist;Pathology;Patient-Focused Outcomes;Patients;personalized medicine;Phase;Procedures;Process;Prognosis;prognostication;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;screening;Services;Site;skills;South Africa;Standardization;symposium;System;targeted treatment;Telepathology;Time;Tissues;Training;Training and Education;Translational Research;United States;United States National Institutes of Health;Universities;Wit;Work;working group

PROJECT_TITLE: Pathology Core


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE: DEVELOPMENTAL CORE The Developmental and Mentoring Core of the UNC-Malawi-South Africa Cancer Consortium (UMSACC) aims to develop Malawian, South African, and U.S. investigators and build capacity to conduct high quality HIV- associated cancer research in Africa. The Core’s focus is to provide mentorship in design and implementation of hypothesis-driven research, manuscript writing, and development of grants.

PI_NAMEs: HOSSEINIPOUR, MINA CHRISTINE (contact)

PROJECT_TERMS: Address;Africa;Africa South of the Sahara;African;AIDS related cancer;anti-cancer research;Applications Grants;Area;Award;Biometry;career;career development;Clinical;Collaborations;Country;Data;Dedications;design;Development;Discipline;Doctor of Philosophy;Educational process of instructing;Epidemiology;Foundations;Funding;Goals;Government;Grant;Health;HIV;innovation;Institution;International;Kaposi Sarcoma;Lead;Leadership;leadership development;low and middle-income countries;Lymphoma;Malawi;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Manuscripts;Measures;Medical;medical specialties;meetings;Mentors;Mentorship;multidisciplinary;next generation;Outcome;Participant;Positioning Attribute;Process;Prognosis;Program Development;programs;Public Health;Public Health Students;Publications;Research;Research Personnel;Research Project Grants;Research Support;screening;skills;Source;South Africa;South African;Structure;student mentoring;success;Supervision;Talents;Time;Training;Training Activity;Training and Infrastructure;Training Programs;Trust;undergraduate medical education;United States National Institutes of Health;Universities;Wit;Writing

PROJECT_TITLE: Developmental and Mentoring Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

PI_NAMEs: MATHEW, GRINU  (contact)

PROJECT_TERMS: advanced disease;American;androgen deprivation therapy;androgen independent prostate cancer;axl receptor tyrosine kinase;Behavior;Biochemical;Biological Assay;Biology;cancer cell;Cancer Etiology;Cancer Patient;Cell Line;Cell Reprogramming;cell type;Cells;Cellular biology;Cessation of life;Chromosome Mapping;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Collection;Compensation;Copy Number Polymorphism;curative treatments;Data;Data Set;Dependence;Development;Disease;DNA Sequence Alteration;Early Diagnosis;Event;Genes;Genetic;genetic approach;Genetically Engineered Mouse;Genomic approach;Genotype;Goals;Growth;Human;Image;in vivo;Indolent;Isogenic transplantation;Link;Maintenance;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;men;Metastatic Prostate Cancer;Modeling;Molecular;Molecular Target;mouse genetics;mouse model;Mus;Nebraska;Neoplasm Metastasis;novel;Oncogenes;Organ;Organoids;Patient Care;Patients;pharmacologic;Phenotype;phosphoproteomics;Phosphotransferases;PIK3CG gene;Primary Lesion;Prostate;prostate cancer cell;prostate cancer metastasis;Protac;PTEN gene;receptor;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Reproducibility;Research;Resistance;Role;Sampling;Shapes;Signal Induction;Signal Transduction;single cell genomics;standard of care;Stress;Techniques;Testing;Therapeutic;TP53 gene;trait;transcriptomic profiling;transcriptomics;translational oncology;transplant model;Tumor Cell Line;Tyrosine;Work

PROJECT_TITLE: Defining and Characterizing Drivers of Lethal Metastatic Prostate Cancer


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Health Services;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE: ANALYTICAL CORE This application responds to RFA-CA-20-001 and will establish a HIV-Associated Malignancy Research Center in the U.S. and Low- and Middle-Income Countries (LMIC) named the UNC-Malawi-South Africa Cancer Consortium (UMSACC). This is a collaborative research center between sites in the USA, Malawi, and South Africa and builds upon strong prior collaborations. The Analytical Core will conduct analyses to support the research projects, assist Malawi and South African researchers to develop and advance their analytical skills through various training activities, and disseminate findings from consortium-sponsored research.

PI_NAMEs: OLSHAN, ANDREW  (contact)

PROJECT_TERMS: Address;Africa South of the Sahara;African;AIDS related cancer;analytical method;anti-cancer research;Area;Back;Bioinformatics;Biological Assay;Biometry;career development;Classification;Clinical Investigator;Collaborations;Competence;Conceptions;cost effectiveness;Country;Data;Data Analyses;Data Collection;data management;Dedications;design;Development;Discipline;diverse data;Ensure;Epidemiology;Faculty;Funding;Genomics;Goals;Grant;Health;health management;Health Policy;health related quality of life;Health Services Research;HIV;Human;Information Dissemination;innovation;Kaposi Sarcoma;low and middle-income countries;Lymphoma;Malawi;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Manuscripts;Measurement;Measures;Mentors;Mentorship;Modeling;Names;neoplasm registry;Non-Hodgkin's Lymphoma;North Carolina;Output;Pathology;Patient Outcomes Assessments;Play;Prognosis;prognostic;programs;Public Health Schools;Records;Reporting;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Support;research to practice;Scientist;screening;Site;skills;Source;South Africa;South African;Southern Africa;Statistical Data Interpretation;synergism;Training;Training Activity;Translational Research;Universities;Work;Writing

PROJECT_TITLE: Analytical Core


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Emerging Infectious Diseases;Genetic Testing;Genetics;HIV/AIDS;Health Services;Hematology;Infectious Diseases;Prevention;Primary Health Care;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

PHR: PROJECT NARRATIVE: PROJECT 1: Urine sampling for HPV infection and methylation testing for cervical cancer screening among women living with HIV in Malawi and South Africa HIV-positive women are at markedly increased risk of human papillomavirus (HPV) infection, cervical precancer and invasive cervical cancer. Despite this, coverage levels for cervical cancer screening remain low, particularly across sub-Saharan Africa, the global epicenter of the HIV epidemic. We propose an innovative project to validate urine-based HPV screening followed by triage of HPV-positive women with a novel methylation test known as S5, which, if successful, could dramatically increase cervical cancer screening globally.

PI_NAMEs: CHIBWESHA, CARLA J (contact)

PROJECT_TERMS: Accounting;Address;Affect;Africa;Africa South of the Sahara;African;African Women;Area;burden of illness;Cancer Detection;Cervical;cervical biopsy;Cervical Cancer Screening;cervicovaginal;Cessation of life;Clinic;Clinical;Collection;Colposcopy;cost effective;Detection;Diagnosis;Diagnostic Procedure;Disease;Disparity;Enrollment;Epidemic;follow-up;Generations;Genes;Goals;high risk;High Risk Woman;HIV;HIV Seronegativity;HIV Seropositivity;HPV negative;HPV positive;HPV screening;HPV-High Risk;Human;Human immunodeficiency virus test;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papillomavirus;Incidence;innovation;Kaposi Sarcoma;Lesion;low and middle-income countries;Lymphoma;Malawi;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;Methods;Methylation;methylation testing;Molecular;mortality;novel;Oncogenic;Pelvic Examination;Performance;Policies;Population;population based;Predictive Value;premalignant;Prognosis;Provider;Public Health;Random Allocation;Reporting;Research;Resource-limited setting;Resources;Risk;Rural;sample collection;Sampling;screening;Sensitivity and Specificity;Services;Site;South Africa;Specificity;Specimen;Testing;treatment strategy;Triage;United States;Urine;Vaccination;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Project 1: Urine sampling for HPV infection and methylation testing for cervical cancer screening among women living with HIV in Malawi and South Africa


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: RAMANATHAN, SUBRAMANIAN PERINKULAM (contact)

PROJECT_TERMS: 3-Dimensional;Address;Alleles;Architecture;base;Biological;Biological Process;biophysical analysis;biophysical properties;biophysical techniques;Cell Nucleus;Cell Shape;Cell Size;cell type;Cells;confocal imaging;Cytosol;Data;Daughter;Development;Diameter;Disease;Disease Progression;Enterocytes;Epithelial Cells;Epithelium;experience;FRAP1 gene;Gene Expression;Genetic;genetic manipulation;Geometry;Goals;Heterogeneity;Homeostasis;human disease;in silico;in vivo;Individual;insight;Intestinal Cancer;intestinal crypt;intestinal villi;Intestines;Knowledge;LGR5 gene;Life;life span;Link;Malignant Neoplasms;Measures;mechanical properties;Mechanics;Methodology;Modeling;Molecular Target;Morphogenesis;Morphology;mosaic;mTOR Signaling Pathway;Mus;Nebraska;novel;Nuclear;Organ;organ growth;Organism;Organoids;Paneth Cells;Pattern;physical property;postmitotic;Process;Property;Regulation of Cell Shape;Role;self assembly;self organization;Shapes;Small Intestines;stem cells;Structure;Testing;Tissues;tumor;tumor progression;Villus;Width;WNT Signaling Pathway;Work

PROJECT_TITLE: Differential Cell Size in Epithelial Packing, Homeostasis, and Disease


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cervical Cancer;Clinical Research;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Precision Medicine;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE: PROJECT 2: Clinical and molecular determinants of HIV-associated Kaposi Sarcoma progression under local standard-of-care therapy in Malawi and South Africa This application responds to RFA-CA-20-001, which asks for applications to establish a joint Research Center in HIV-Associated Malignancy in U.S. and Low- and Middle-Income Country (LMIC). We propose to establish a collaborative center between the US, Malawi and South Africa. Project 2- Kaposi Sarcoma seeks to identify clinical and molecular markers of disease that can be used to predict outcome to local standard of care (prognostic biomarkers).

PI_NAMEs: DITTMER, DIRK P (contact)

PROJECT_TERMS: Adopted;Africa;Africa South of the Sahara;AIDS clinical trial group;AIDS Malignancy Consortium;AIDS related cancer;AIDS with Kaposi's sarcoma;Area;base;Biological;biomarker performance;Biopsy;Bleomycin;Blood;Caring;Cells;Clinical;Clinical Markers;Clinical Trials;cohort;Cohort Studies;Collaborations;Collection;Country;Data Set;Detection;Disease;Disease Marker;Eligibility Determination;Enrollment;Europe;exceptional responders;exosome;experience;Funding;Gene Expression Profile;Gene Expression Profiling;Genetic Transcription;Genome;genome sequencing;Genomics;Goals;HIV;Hospitals;Human;Human Herpesvirus 8;IL6 gene;Incidence;innovation;Institutional Review Boards;Interleukin-10;Iris;Joints;Kaposi Sarcoma;Link;Liposomal Doxorubicin;low and middle-income countries;Lymphoma;Lymphoproliferative Disorders;Malawi;Malignant neoplasm of cervix uteri;Malignant neoplasm of prostate;Malignant Neoplasms;men;Mentors;Molecular;molecular marker;North Carolina;Nucleotides;outcome prediction;Paclitaxel;Pathogenesis;Pathology;Patients;Persons;Population;Positioning Attribute;Productivity;Prognosis;Prognostic Factor;Prognostic Marker;Public Sector;Publications;randomized, clinical trials;Research;Research Personnel;response;response biomarker;Saliva;screening;sex;Shipping;Site;South Africa;Stains;standard of care;Testing;Time;treatment guidelines;treatment response;Trust;United States National Institutes of Health;Universities;Variant;Vincristine;Viral;Viral Load result;whole genome;Work

PROJECT_TITLE: Project 2: Clinical and molecular determinants of HIV-associated Kaposi Sarcoma progression under local standard-of-care therapy in Malawi and South Africa


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Kidney Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative The identification of new focal segmental glomerulosclerosis (FSGS) and nephrotic syndrome (NS) genes and further genetic characterization of known FSGS/NS genes will have significant implications for understanding, and ultimately, treating, common forms of kidney disease and progression to kidney failure. In the more immediate future, identification and characterization of FSGS/NS gene defects will have implications for the development of diagnostic tools. !

PI_NAMEs: HILDEBRANDT, FRIEDHELM ;POLLAK, MARTIN R. (contact);SAMPSON, MATTHEW GORDON;SANNA-CHERCHI, SIMONE

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acceleration;Address;Affect;aggregation database;Alleles;analytical method;Animal Model;Biological Assay;Biological Models;Biology;Cells;Classification;Clinical;cohort;Collection;Communities;Complex;Copy Number Polymorphism;Data;data integration;data resource;Defect;Development;diagnostic accuracy;diagnostic development;diagnostic tool;Disease;disease model;empowerment;Enhancers;Etiology;exome;exome sequencing;Focal and Segmental Glomerulosclerosis;Future;gene discovery;Gene Frequency;gene interaction;Genes;Genetic;genetic disorder diagnosis;genetic profiling;genetic testing;Genetic Transcription;genetic variant;Genetic Variation;genome sequencing;genome-wide;Genomics;Genotype;Goals;Heritability;Human;human model;improved;Individual;induced pluripotent stem cell;Informatics;insertion/deletion mutation;Internet;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;Laboratories;Lead;Medical Genetics;Methods;Modeling;Molecular Structure;Mutate;Mutation;Nephrotic Syndrome;novel;nutritional supplementation;Outcome;parallelization;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Penetrance;Phenotype;predicting response;Prevalence;promoter;Reagent;Reporting;Research;Research Personnel;response;Risk;Sample Size;Single Nucleotide Polymorphism;Site;SNP array;Standardization;Steroid therapy;Steroid-resistant idiopathic nephrotic syndrome;System;Technology;Test Result;Testing;Therapeutic;Variant;web portal;Work;Zebrafish

PROJECT_TITLE: Integrating large scale genomics and functional studies to accelerate FSGS/NS discovery


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cervical Cancer;Clinical Research;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Prevention;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE: PROJECT 3: Tumor-associated biomarkers for HIV-associated Diffuse Large B- cell Lymphoma in Malawi and South Africa Diffuse Large B-cell Lymphoma (DLBCL), the most common lymphoma worldwide, is highly associated with HIV, but prognostic determinants and molecular analyses of HIV-associated DLBCL are notably lacking. Leveraging the unique clinical, diagnostic and sequencing infrastructure, and advanced bioinformatics expertise, we aim to comprehensively investigate key molecular determinants and characteristics of the tumor niche in DLBCL across the spectrum of HIV-associated immune dysfunction in South Africa and Malawi.

PROJECT_TERMS: Achievement;advanced analytics;Africa South of the Sahara;Age;Aging;AIDS-Related Lymphoma;Appearance;Behavioral;Bioinformatics;Biological Factors;Biological Markers;Cancer Etiology;cancer risk;Caring;Cessation of life;Characteristics;chemotherapy;Clinical;clinical remission;Clinical Research;Clinical Trials Design;cohort;Cohort Studies;Collaborations;comparison group;Core Facility;Country;Data;Diagnosis;Diagnostic;differential expression;DNA Sequencing Facility;Environment;Epidemic;experience;Future;Gene Expression Profile;Genes;Genomics;Goals;Histologic;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;Hospitals;Immune;Immune System Diseases;Immunocompetent;Immunogenomics;Immunologics;Immunophenotyping;improved;improved outcome;Incidence;Income;Individual;individualized medicine;Inflammatory;Infrastructure;innovation;insight;Kaposi Sarcoma;large cell Diffuse non-Hodgkin's lymphoma;low income country;Lymphoma;Lymphomagenesis;Malawi;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Molecular;Molecular Analysis;Newly Diagnosed;Outcome;Patient-Focused Outcomes;Patients;Pattern;Persons;Population;Population Growth;Prognosis;prognostic;Prognostic Marker;Proliferating;prospective;Prospective cohort;Regional Disease;Research;Resources;response;Risk Factors;risk stratification;routine care;scale up;screening;Site;sociodemographic factors;South Africa;specific biomarkers;Speed;Tissue Sample;transcriptome;transcriptome sequencing;Translational Research;tumor;Tumor Biology;tumor microenvironment;tumor-immune system interactions;Universities;Vulnerable Populations;Wit;Work

PROJECT_TITLE: Project 3: Tumor-associated biomarkers for HIV-associated Diffuse Large B-cell Lymphoma in Malawi and South Africa


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Eye Disease and Disorders of Vision;Genetics;Rare Diseases;Skin Cancer

PI_NAMEs: YOO, JAE HYUK  (contact)

PROJECT_TERMS: activating transcription factor 1;Ankyrin Repeat;apoAI regulatory protein-1;Architecture;beta catenin;Binding;Biological Assay;breast cancer metastasis;Cell Culture Techniques;Cell membrane;cell motility;Cell Nucleus;Cells;Chromosome 3;Chromosomes;Country;COUP transcription factor I;Critical Pathways;Cytoplasmic Vesicles;Cytoskeleton;Data;Development;Disease;EMS1 gene;Exhibits;experimental study;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;GNAQ gene;Growth;GTPase-Activating Proteins;Human;human model;In Vitro;in vivo;Incidence;inhibitor;insight;Invaded;knock-down;Learning;Length;Liver;Malignant Breast Neoplasm;Malignant Neoplasms;MAP Kinase Gene;Mediating;Melanoma;Melanoma Cell;Melanoma patient;Metastatic Melanoma;Metastatic Neoplasm to the Liver;Molecular;Molecular Target;Monomeric GTP-Binding Proteins;Monosomy;mouse model;Mus;Mutation;Nebraska;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Oncogenic;overexpression;Pathway interactions;Patients;paxillin;Persons;PH Domain;pharmacologic;phospholipase C beta;pre-clinical;prevent;Process;Prognosis;Proliferating;Protein Kinase C;protein kinase C beta;Proteins;Publishing;Research;Role;SH3 Domains;Signal Pathway;Signal Transduction;STAT4 gene;Testing;trafficking;transcription factor;Transcription Factor AP-1;tumor;tumor progression;Tumor Promotion;tumorigenesis;Uveal Melanoma;wound healing;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeting ASAP1-Controlled Signal Pathways to Inhibit Uveal Melanoma Metastasis


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Disability and deaths related to otolaryngologic diseases have a significant public health impact nationally; however, recent advances in molecular and cellular biology, pharmaceutics, bioengineering, inner ear physiology, and voice analysis are translating scientific discovery to impact health. The UCLA Department of Head and Neck Surgery is dedicated to the mentoring and interdisciplinary team-based training of a new generation of academic leaders in disease-related research. By employing the expertise and resources of our renowned multidisciplinary mentor faculty, we will fulfill the program mission of training a cadre of investigators who will discover novel underlying basic principles of otolaryngology-related diseases and translate these discoveries to improve health.

PI_NAMEs: LONG, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Area;Behavioral Research;Bioinformatics;Biomedical Engineering;Biomedical Research;Biometry;California;career;Career Choice;Cessation of life;Charge;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communication;Communication impairment;Communities;deafness;Dedications;design;Development;Development Plans;disability;Disease;diversity and inclusion;Education;education pathway;education research;Educational Curriculum;Ensure;Ethics;experience;Faculty;faculty mentor;Funding;Future;Generations;Grant;Growth;Head and Neck Cancer;Head and Neck Surgery;Health;Hearing;Human Resources;Immersion;improved;Individual;innovation;interest;Interview;Investments;Journals;Knowledge;Labyrinth;Larynx;Lead;lecturer;lectures;Los Angeles;medical specialties;Medical Students;Medicine;member;Mentors;Mentorship;Mission;Molecular and Cellular Biology;multidisciplinary;novel;Otolaryngology;Perception;Persons;Pharmacy (field);Physicians;Physiology;programs;Public Health;Publications;Qualifying;Recording of previous events;Research;Research Ethics;research faculty;Research Personnel;Research Project Grants;Resources;Scientist;Series;skill acquisition;skills;Structure;Students;success;Surgeon;Talents;Time;Training;Training Programs;Translating;Translational Research;Universities;Vestibular function;Vision;Visit;Voice;women faculty;Writing

PROJECT_TITLE: Enabling careers as surgeon-scientists in otolaryngology-head and neck surgery


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PHR: PROJECT NARRATIVE Widespread variation exists between species in the size, shape, and number of chromosomes, and these differences can have profound influences on genetic variation and reproductive compatibility. This research will identify patterns of chromosome evolution and centromere- associated satellite DNA turnover in the well-established Drosophila model system to help us understand evolutionary transitions. I will also investigate a unique beetle model with an evolutionarily young sex chromosome system to analyze rapid Y chromosome degeneration and reproductive incompatibility.

PI_NAMEs: BRACEWELL, RYAN  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Behavior;Bioinformatics;Biological Models;Centromere;Chromosome Arm;Chromosome Structures;Chromosomes;comparative;Coupled;DNA Sequence;DNA Transposable Elements;Drosophila genus;Evolution;Gene Expression;Gene Expression Regulation;Gene Order;Gene Structure;Genes;Genetic;genetic information;Genetic Variation;Genome;genome sequencing;genome-wide;Genomics;Karyotype;Karyotype determination procedure;Life;Link;Maintenance;Modeling;Order Coleoptera;Pattern;Population;Positioning Attribute;Process;reproductive;Research;Role;Satellite DNA;segregation;Sex Chromosomes;sex determination;Shapes;Structure;System;Time;transmission process;Trees;Variant;whole genome;Y Chromosome

PROJECT_TITLE: Chromosome evolution and rapid Y chromosome degeneration

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on developing a clinical decision support tool for the identification, diagnosis, and treatment of hospitalized patients at high risk of clinical deterioration. This work will result in novel algorithms that can be implemented to deliver early, personalized care to decrease preventable morbidity and mortality from deterioration. Therefore, the proposed research is relevant to the part of the NIH’s mission that pertains to enhancing health, lengthening life, and reducing illness and disability.

PI_NAMEs: CHURPEK, MATTHEW MICHAEL (contact)

PROGRAM_OFFICER_NAME: REIS, JARED P

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Admission activity;Adult;Algorithms;Antibiotics;Caring;case-based;Cessation of life;Clinical;clinical decision support;clinical diagnosis;clinical practice;clinical risk;common treatment;Complex;Congestive Heart Failure;convolutional neural network;cost outcomes;Critical Care;Critical Illness;Data;Data Set;Decision Making;design;Deterioration;Diagnosis;Diagnostic;diagnostic accuracy;disability;discrete time;Early Diagnosis;Effectiveness;Electronic Health Record;Etiology;Event;experience;explainable machine learning;Fatigue;Goals;graphical user interface;Health;Health system;high risk;Hospital Mortality;Hospitalization;Hospitals;Hour;Human;improved;improved outcome;innovation;Intensive Care;iterative design;Laboratories;Lead;Learning;learning strategy;Life;Machine Learning;machine learning framework;machine learning method;machine learning model;Manuals;Medical;Medical Errors;Mission;Modeling;Morbidity - disease rate;mortality;multitask;Natural Language Processing;novel;Operative Surgical Procedures;optimal treatments;Outcome;Patient-Focused Outcomes;Patients;personalized care;personalized intervention;Prediction of Response to Therapy;predictive modeling;preventable death;Provider;Psychological reinforcement;Public Health;Recommendation;recurrent neural network;Research;Resources;Risk;Risk Factors;satisfaction;Sepsis;simulation;Source;Structure;structured data;support tools;Testing;Time;tool;transfer learning;Trees;United States National Institutes of Health;user centered design;ward;Work

PROJECT_TITLE: Developing a clinical decision support tool for the identification, diagnosis, and treatment of critical illness in hospitalized patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-E(09)]


ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: This Program represents a cohesive approach motivated by the practical needs of very high-throughput radiation biodosimetry in a variety of very different large-scale exposure scenarios, to estimate past individual dose and to predict individual sensitivity to future injury. A central characteristic remains focus on three different approaches: fully automated cytogenetics, gene expression, and metabolomics; these have different balances of capabilities in terms of throughput, time-to-result, signal lifetime, dose reconstruction, exposure scenario identification and individual radiosensitivity prediction, and the final goal is to quantify their optimal integrated usage in each of the many different potential exposure scenarios.

PI_NAMEs: BRENNER, DAVID JONATHAN (contact)

PROGRAM_OFFICER_NAME: TALIAFERRO, LANYN P

PROJECT_TERMS: Advisory Committees;Animals;assay development;biodosimetry;Biological Markers;Biological Models;Biometry;Blood;Characteristics;Complex;Cytogenetics;Development;Devices;Disease;Dose;Dose Rate;dosimetry;Event;exposed human population;functional genomics;Funding;Future;Gene Expression;Goals;Human;in vivo;Individual;Injury;interdisciplinary approach;irradiation;Late Effects;Late Radiation Injury;Lung;Lung Diseases;member;metabolomics;minimally invasive;National Institute of Allergy and Infectious Disease;Nature;Neutrons;Nuclear;organizational structure;personalized approach;personalized predictions;Persons;Photons;Population;Positioning Attribute;predicting response;predictive marker;product development;programs;Radiation;Radiation Tolerance;reconstruction;Research;Research Project Grants;Resources;response;senescent cell;Signal Transduction;System;Technology;Time;transcriptomics;Work

PROJECT_TITLE: Center for High-Throughput Minimally-Invasive Radiation Biodosimetry


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Physical Injury - Accidents and Adverse Effects

PROJECT_TERMS: Accountability;Advisory Committees;Annual Reports;biodosimetry;Blinded;Budgets;Certification;Collaborations;Communication;data access;Data Analyses;data sharing;Decision Making;Dose;Ensure;Evaluation;experimental study;Fostering;Goals;Information Technology;Institution;Intellectual Property;invention;Leadership;Legal patent;mass casualty;Medical center;meetings;minimally invasive;National Institute of Allergy and Infectious Disease;organizational structure;Periodicals;Productivity;Radiation;Radiation Accidents;Radiation exposure;reconstruction;Reporting;Research;Research Personnel;Research Support;Resource Allocation;Resources;Sampling;Structure;Technology;Teleconferences;tool;Travel;Universities;web services;web site;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: IRVINE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Summary In this 3-year study, California’s Refugee Reproductive Health Network (ReproNet) will aim to (1) Create a publicly-available digital repository of multilingual reproductive health resources (Dari, Pashto, Arabic) for Afghan and Arab refugee populations (2) Enhance Afghan and Arab refugee’s reproductive health literacy in California through 24 in-person and on-line training sessions and (3) Increase the capacity of refugee programs to integrate RH literacy in their programs.

PI_NAMEs: THIEL DE BOCANEGRA, HEIKE  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: abortion;American;Arabs;Awareness;California;Caring;clinical care;Communities;community academic partnership;community engagement;community partnership;Contraceptive methods;County;digital;digital health;Digital Libraries;digital repositories;Discipline of obstetrics;Disparity;E-learning;education resources;Ensure;Evaluation;experience;Facebook;Faculty;Familiarity;Family;Foundations;Gender;girls;Health;health care service utilization;health equity;health knowledge;health literacy;Health Personnel;Health Promotion;Health Resources;Health Services Accessibility;Healthcare;Healthcare Systems;Immigrant;improved;Infant Health;Infrastructure;Intervention;Knowledge;Language;Libraries;Linguistics;Link;literacy;Literacy Programs;Malignant neoplasm of cervix uteri;Maternal Health;migration;Multilingualism;Muslim population group;online repository;Outcome;outreach;Persons;podcast;Population;Poverty;preference;Pregnancy;pressure;Preventive care;Preventive service;Process;programs;Provider;Refugees;Reporting;repository;Reproductive Health;Resources;Risk;Scholarship;service providers;Services;sexual and reproductive health;sexual violence;skills;social media;Social Network;Social Work;Societies;socioeconomics;Solid;Spontaneous abortion;Strategic Planning;Time;trafficking;Training;Training and Education;Trauma;Unemployment;UNHCR;United States;United States National Library of Medicine;Universities;Visual;webinar;Well in self;Woman;women's reproductive health;Work;Writing

PROJECT_TITLE: Reproductive Health Equity in Afghan and Syrian newcomers through digital health literacy


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Prevention

PI_NAMEs: AMUNDSON, SALLY A. (contact)

PROJECT_TERMS: Acute;Advanced Development;Advertising;Award;Basic Science;biodosimetry;Collaborations;Communication;data sharing;Development;Documentation;Funding;Funding Opportunities;IACUC;Injury;innovation;Institution;Institutional Review Boards;Investigational Drugs;medical countermeasure;meetings;minimally invasive;operation;outreach;Pilot Projects;posters;Prevention;Procedures;Process;programs;Progress Reports;Radiation;Radiation Injuries;recruit;Reporting;Research;research and development;Role;Societies;Teleconferences;Translational Research;United States National Institutes of Health;Update;web page

PROJECT_TITLE: Opportunities Fund Management Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures

PI_NAMEs: PONNAIYA, BRIAN  (contact)

PROJECT_TERMS: Adherence;Age;Anesthesia procedures;Animal Euthanasia;Animals;biodosimetry;Biological Markers;Blinded;Blood;Blood specimen;Breeding;Caring;Cell Count;Cells;Code;Collaborations;Collection;data integration;Distress;Dose Rate;Euthanasia;experience;experimental study;Grant;Guidelines;Hematology;Housing;Human Resources;IACUC;Immunophenotyping;irradiation;Lung Diseases;Maintenance;minimally invasive;Mission;Monitor;Mus;Neutrons;nonhuman primate;Pain;Radiation;radiation response;Resources;sample collection;Sampling;senescent cell;Services;Stress;Transgenic Mice;Urine;Vendor

PROJECT_TITLE: Animal Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research

PI_NAMEs: GARTY, GUY Y (contact)

PROJECT_TERMS: Address;Back;biodosimetry;Blood;bone;Chest;Clinical;Collaborations;Compensation;Data;design;detector;Devices;Dose;Dose Rate;dosimetry;Encapsulated;Ensure;experimental study;Film;Funding;Gamma Rays;Goals;In Vitro;in vivo;innovation;ionization;irradiation;Location;Lung;Maintenance;Measures;microCT;minimally invasive;Mission;Modality;Mus;National Institute of Allergy and Infectious Disease;Neutrons;Nuclear;operation;Organ;Photons;Plastics;Procedures;programs;Protocols documentation;Quality Control;Radiation;Radiation exposure;Radiation Physics;Radiology Specialty;Radiometry;Reproducibility;Research;Roentgen Rays;Series;Services;Slice;soft tissue;Source;spectral energy;Standardization;subcutaneous;success;System;Techniques;Technology;Tissues;Variant

PROJECT_TITLE: Irradiation & Dosimetry Core


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: WACO

ORG_NAME: BAYLOR UNIVERSITY

ORG_STATE: TX

PHR: Improving written and subsequent spoken language outcomes of individuals with intellectual and developmental disabilities, a historically under researched group, has important public health implications. The proposed research is a small, randomized controlled trial that examines the effect of written language intervention for functional texts on proximal and distal written and spoken language outcomes of 40 young adults with intellectual and developmental disabilities. Evaluating effective intervention strategies for individuals with intellectual and developmental disabilities supports NIDCD’s mission of behavioral research aimed to remediate the disordered process of language development in individuals with communication disorders.

PI_NAMEs: PRAHL, ALISON J (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Achievement;Activities of Daily Living;Address;Adolescence;Adult;American;Awareness;Behavioral Research;Clinical Trials;Communication;Communication impairment;Complex;Comprehension;Control Groups;Data;design;Disease;Distal;Education;Educational process of instructing;effective intervention;Effectiveness;Electronic Mail;Enrollment;Fostering;Future;Goals;high school;improved;Independent Living;Individual;Intellectual functioning disability;Intervention;intervention effect;Intervention Studies;Language;Language Development;Language Disorders;language outcome;Life;literacy;literate;Measures;Mission;Motivation;National Institute on Deafness and Other Communication Disorders;Occupational;Oral;Outcome;Participant;Phenotype;Pilot Projects;Population;post intervention;Procedures;Process;programs;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Reader;Reading;reading comprehension;remediation;Research;response;Secondary to;service delivery;skills;systematic review;Text Messaging;text messaging intervention;Time;treatment as usual;treatment group;trial design;Underrepresented Populations;Vocabulary;Vocation;Writing;young adult

PROJECT_TITLE: Optimizing Language Outcomes for Young Adults with Intellectual and Developmental Disabilities: A Written Language Intervention Using Functional Texts

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Data Science;Lung;Machine Learning and Artificial Intelligence;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention

PI_NAMEs: SHURYAK, IGOR  (contact)

PROJECT_TERMS: Acute;adverse outcome;Benchmarking;biodosimetry;Biological;Biological Assay;Biological Markers;biological systems;biomarker identification;biomarker signature;Biometry;Biostatistics Core;Blood;Bone Marrow;Calibration;Cell Count;Cells;Cessation of life;Classification;Code;Complex;Custom;Cytogenetic Analysis;Cytogenetics;Data;Data Analyses;Data Set;decision tree learning;Decision Trees;design;Development;dimension reduction;Dimensions;Dose;Dose Rate;Ensure;Event;Experimental Designs;experimental study;Generations;Goals;gradient boosting;Health;Hematopoietic;Human;improved;in vivo;indexing;Individual;Injury;Investigation;Ionizing radiation;irradiation;Label;Linear Models;Logistic Regressions;Lung Diseases;lung injury;Machine Learning;machine learning classification;machine learning method;mass casualty;mathematical model;Measurement;Measures;metabolomics;Methodology;Methods;micronucleus;minimally invasive;Modeling;Mus;Names;Neutrons;Noise;nonhuman primate;organ injury;Outcome;Performance;peripheral blood;personalized predictions;Photons;Productivity;Proportional Hazards Models;Pulmonary Inflammation;R programming language;Radiation;Radiation Dose Unit;radiation effect;Radiation exposure;Radiation Injuries;Radiation Pneumonitis;radiation response;random forest;Randomized;reconstruction;Reproducibility;Research Personnel;response;response biomarker;Sampling;senescent cell;Shapes;specific biomarkers;Statistical Models;synergism;System;Techniques;Testing;Time Series Analysis;tool;training data;transcriptomics;Transgenic Mice;translational approach;Uncertainty;Validation;Writing

PROJECT_TITLE: Biostatistics Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Genetics;Mental Health;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: This  study  aims  to  understand  the  unique  properties  of  the  blood  vessels  of  the  central  nervous  system.  The  findings  from  this  study  will  provide  the  scientific  community  a  novel  understanding  of  how  blood  vessels  influence the function of neurons and a novel perspective on how to treat neurological disorders.

PI_NAMEs: MUNJI, ROEBEN  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Affect;Alzheimer's Disease;Amino Acids;Amygdaloid structure;antagonist;Anxiety;approach behavior;Behavior;behavioral response;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier function;Brain;brain endothelial cell;Brain region;brain tissue;Cells;Central Nervous System;central nervous system vasculature;Chromosome Mapping;Communities;Cues;Darkness;Data;DOPA decarboxylase;Dopamine;Dopamine Agonists;Dopamine Antagonists;Dopamine Receptor;Endothelial Cells;Endothelium;Enzymes;Epilepsy;experience;extracellular;Functional disorder;Genes;Genetic;Genetic Transcription;Glucose;habituation;Haloperidol;Health;High Pressure Liquid Chromatography;Hormones;Housing;Immunologic Surveillance;Ions;Knock-out;Knockout Mice;Lateral;Lead;Learning;Light;Link;liquid chromatography mass spectrometry;Measures;Metabolic;Metabolic Pathway;Metabolism;Modeling;monoamine;Monoamine Oxidase;Moods;mouse model;Movement;Multiple Sclerosis;Mus;Nervous System Disorder;neural;neural circuit;Neurodevelopmental Disorder;Neuromodulator;Neurons;Neurophysiology - biologic function;neuropsychiatric disorder;neurotransmitter metabolism;Neurotransmitters;novel;Nutrient;Pain Disorder;painful neuropathy;Parkinson Disease;pathogen;Phenotype;Post-Translational Protein Processing;Process;Property;Proteins;Regulation;response;Rewards;ropinirole;sensory stimulus;Serotonin;Signal Transduction;Signaling Molecule;social;Social Behavior;Social Interaction;Social isolation;spatial memory;Stimulus;Stroke;Synapses;synaptic function;System;Testing;Tight Junctions;Tissues;Toxin;transcytosis;uptake;Vascular Endothelial Cell

PROJECT_TITLE: Endothelial monoamine neurotransmitter metabolism at the blood-brain barrier


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research

PROJECT_TERMS: Address;Age;Animals;assay development;Automation;biodosimetry;Biological Assay;Biological Markers;Biological Models;Biostatistics Core;Blood;Blood specimen;blood-based biomarker;Calibration;Cell Culture Techniques;Child;Chromosome Condensation;Coupled;Cytogenetics;Data;Decision Trees;Development;Dose;Dose Rate;exposed human population;Female;Gene Expression;Goals;healthy volunteer;high throughput screening;Hour;Human;Image;Image Analysis;In Vitro;in vivo;Individual;irradiation;Knowledge;male;metabolomics;micronucleus;Micronucleus Tests;minimally invasive;Mus;Neutrons;Photons;premature;Preparation;programs;Radiation;Radiation Accidents;Radiation Tolerance;reconstruction;Robotics;Sampling;sex;Signal Transduction;System;Testing;Time;tool;transcriptomics;Validation;Variant

PROJECT_TITLE: Rapid Automated High-Throughput Radiation Biodosimetry


ORG_CITY: CLEVELAND

ORG_DEPT: BIOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Aneuploidy, the state of having too many or too few chromosomes, is a leading cause of developmental diseases, miscarriages, and failed pregnancies using assisted reproductive technology. The cell has many mechanisms to ensure correct chromosome segregation, including creating crossovers between chromosomes. This grant proposes to study how crossovers are made and the underlying causes of chromosome aneuploidy.

PI_NAMEs: CROWN, KIMBERLY NICOLE (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;Aneuploidy;Area;Assisted Reproductive Technology;Biological Assay;Bypass;Candidate Disease Gene;Cells;Chromosome Segregation;Chromosome Structures;Chromosomes;Cross-Over Studies;developmental disease;DNA Double Strand Break;Double Strand Break Repair;Drosophila melanogaster;Ensure;Event;experimental study;Genes;Genetic;genetic analysis;Genetic Recombination;genome-wide;Grant;Heterozygote;Hi-C;Human;Infertility;Kinetics;Lead;Mediating;Meiosis;Meiotic Recombination;Modeling;Molecular Genetics;Outcome;Pathway interactions;Pattern;Population;pregnancy failure;repaired;Research;Spontaneous abortion;superresolution imaging;Synaptonemal Complex;System;Variant

PROJECT_TITLE: Chromosome structural variants in meiosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Parkinson's Disease;Psychosis;Serious Mental Illness

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative In addition to the characteristic motor symptoms, patients with Parkinson’s disease (PD) also experience significant neuropsychiatric symptoms. Using detailed behavioral testing and high-resolution brain imaging methods, this project aims to examine brain regions known to play an important role in memory function and hallucinations in participants with PD and shed light on the relationship between changes in these brain regions and the parallel clinical course of memory deficits and hallucinations in PD patients with memory impairment or hallucinations compared to PD patients without memory impairment or hallucinations, and healthy controls. Repeat clinical assessment two years after neuroimaging will determine whether changes on fMRI associated with memory impairment and hallucinations in PD are predictive of future cognitive or functional decline and may be a target for intervention.

PI_NAMEs: BAKKER, ARNOLD  (contact);PONTONE, GREGORY MICHAEL

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Affect;Animals;Anxiety;behavior test;Bradykinesia;Brain imaging;Brain region;Caregiver Burden;Characteristics;Clinical;Clinical assessments;Cognitive;cognitive impairment in Parkinson's;cognitive task;cognitive testing;common symptom;comparison control;daily functioning;Data;Dementia;dementia risk;dentate gyrus;design;Development;Diagnosis;disability;Episodic memory;episodic memory impairment;Etiology;Executive Dysfunction;experience;follow-up;functional decline;Functional disorder;Functional impairment;Functional Magnetic Resonance Imaging;Future;Goals;Hallucinations;High Prevalence;hippocampal subregions;Hippocampus;Human;Hyperactivity;imaging modality;Impaired cognition;Impairment;Individual;insight;Intervention;Link;Measures;medial temporal lobe;Memory;Memory impairment;memory recall;Mental Depression;Methods;mortality;motor symptom;Nerve Degeneration;network dysfunction;Neurobehavioral Manifestations;neuroimaging;neuropsychiatric symptom;Neuropsychology;non-motor symptom;novel therapeutic intervention;novel therapeutics;Nursing Homes;Parkinson Disease;Participant;patient subsets;Patients;Play;Predictive Value;Process;prognostic value;psychiatric symptom;Psychoses;Psychotic Disorders;Quality of life;Reporting;Resolution;Rest;Risk;Role;Structure;Symptoms;Taxes;Temporal Lobe;Testing;Tremor;Visual Hallucination;visual memory;Work

PROJECT_TITLE: Visual hallucinations and memory impairment in Parkinson's Disease: The role of hippocampal networks

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]