NIH_SPENDING_CATS: Comparative Effectiveness Research;Mental Health;Pediatric

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: Project Narrative Poor fidelity decreases the public health impact of measurement-based care (MBC) for youth and their families. Research that pinpoints specific ways to optimize the effectiveness of MBC for youth is thus needed. The proposed study aims to address this gap by identifying the practices that need to be delivered to optimize the effectiveness of MBC for youth.

PI_NAMEs: JENSEN-DOSS, AMANDA  (contact);MCLEOD, BRYCE DOUGLAS

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Address;Adherence;Adolescent;care systems;Caregivers;Caring;Client;Clinic;Clinical;Collaborations;Collection;Communities;Community Mental Health Centers;Competence;Connecticut;cost;cost effective;Data;Data Sources;design;Development;Diagnostic;digital;Dimensions;Discrimination;Effectiveness;effectiveness/implementation hybrid;Emotional disorder;Ensure;Evidence based practice;Evidence based treatment;Family;Feedback;Florida;Funding;Goals;implementation strategy;improved;Individual;Influentials;informant;Literature;Measurement;Measures;Mental Health;Methods;Modeling;Monitor;National Institute of Mental Health;Outcome;Outcome Study;Patient Self-Report;performance based measurement;Property;Protocols documentation;Proxy;Psychometrics;Public Health;randomized effectiveness trial;Reporting;Research;response;Sampling;Symptoms;System;Teenagers;Testing;Theoretical model;theories;treatment as usual;treatment planning;trial comparing;Youth

PROJECT_TITLE: Enhancing the effectiveness of measurement-based care for youth by identifying key fidelity indicators

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: This research will reveal the novel mechanism of tumor suppressor protein PALB2 in DNA repair and will shed light on function of multiple structurally disordered regions in human proteome. The findings will advance insight into cancer etiology, aging, neurodegeneration, and other pathologies.

PI_NAMEs: KOROLEV, SERGEY  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Affect;Affinity;Aging;alpha helix;Amino Acids;analytical ultracentrifugation;base;Binding;Binding Sites;Biochemical;Biological Process;Biophysics;BRCA1 gene;BRCA2 gene;BRCA2 Protein;Cancer Etiology;Cardiovascular Diseases;Cells;Chromosomal Breaks;Chromosomes;Circular Dichroism;Complex;design;dimer;Dimerization;Disease;DNA;DNA analysis;DNA Binding;DNA Binding Domain;DNA metabolism;DNA Repair;DNA Structure;Drug resistance;ds-DNA;Electron Spin Resonance Spectroscopy;Electrons;Energy Transfer;Fostering;Future;Genetic Recombination;Genome;globular protein;Goals;homologous recombination;Human;human disease;insight;Intrinsic drive;Kinetics;Knowledge;light scattering;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Membrane;Methods;Molecular;Molecular Chaperones;Molecular Conformation;Molecular Sieve Chromatography;Mutagenesis;mutant;Nerve Degeneration;novel;nucleic acid metabolism;Nucleic Acids;Organelles;Organism;PALB2 gene;Pathology;Physiological;Post-Translational Protein Processing;Predisposition;Property;protein function;protein metabolism;Proteins;Proteome;Rad51 recombinase;Reaction;Regulation;Repair Complex;repaired;Research;RNA;RNA metabolism;Roentgen Rays;Role;scaffold;Scaffolding Protein;single molecule;Single-Stranded DNA;Spectrum Analysis;Structure;Tertiary Protein Structure;Testing;tool;Tumor Suppressor Proteins;Work

PROJECT_TITLE: Mechanism of homologous recombination driven by the intrinsically disordered domain of tumor suppressor PALB2

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Bioengineering;Biotechnology;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Congenital Heart Disease;Dementia;Heart Disease;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Our overall goal is to understand the role of right-to-left shunting in PFO-related stroke and other neurovascular injury with respect to novel biochemical risk factors we have identified. We discovered that shunting via PFO produces a chronic procoagulable blood profile that exposes the brain to harm and causes neurovascular injury. Building on our prospective longitudinal PFO patient cohort and multidisciplinary clinical and translational approach, we aim to advance the understanding of this mechanism to benefit our high-risk patients excluded from pivotal clinical trials.

PI_NAMEs: NING, MINGMING  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Affect;Aftercare;Agreement;Alzheimer's disease related dementia;Animal Model;biobank;Biochemical;Biochemistry;Biological Assay;Biological Markers;Blood;blood-brain barrier permeabilization;Brain;brain endothelial cell;Brain Injuries;Brain-Derived Neurotrophic Factor;caveolin 1;Cell Culture Techniques;Cell Differentiation process;Cell Physiology;Cell Survival;Cerebral endothelium;Cerebrospinal Fluid;Cerebrovascular system;Characteristics;Chronic;Clinic;Clinical;clinical translation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Coagulation Process;Cognitive;cohort;Critiques;Data;Development;Dextrans;Drug Targeting;Endothelium;Enrollment;Enzymes;Etiology;Exclusion;experimental study;Fibroblast Growth Factor;Folic Acid;follow-up;Foundations;Functional disorder;Future;Genes;Glutamates;Goals;Health;Heart Atrium;high risk;Homocysteine;Image;Impaired cognition;In Vitro;in vitro Model;indexing;Individual;Injury;innovation;Intervention;irritation;Ischemia;knock-down;Knowledge;Learning;Left;Life;Long-Term Effects;Longitudinal Studies;Longterm Follow-up;loss of function;Magnetic Resonance Imaging;Measures;multidisciplinary;neurovascular;neurovascular injury;novel;oligodendrocyte progenitor;Outcome;overexpression;Patent Foramen Ovale;Pathway interactions;Patients;Pattern;Permeability;personalized care;Physiology;post stroke;precursor cell;Prevention strategy;Productivity;Progress Reports;prospective;Proteomics;Publications;Pyruvate;Recommendation;Recurrence;Reporting;response;Risk;Risk Factors;Role;Scientific Advances and Accomplishments;Serum Albumin;Shunt Device;Stroke;stroke patient;Tight Junctions;Time;translational approach;Travel;treatment strategy;trial enrollment;United States National Institutes of Health;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;vascular injury;Venous;Vitamin B Complex;white matter;White Matter Disease;White Matter Hyperintensity

PROJECT_TITLE: Proteomic Profiling of Patent Foramen Ovale Related Neurovascular Injury

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: ATLANTA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The project targets disease ruling with diagnostic tests, lays out an analytic framework for clinical utility eval- uation, and develops statistical and computational methods for multiplex rule formulation and performance estimation. These tools will facilitate personalized treatment and patient care for cancers and other diseases.

PI_NAMEs: HUANG, YIJIAN  (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Address;Adopted;Affect;analytical method;anti-cancer research;Biological;Biological Markers;Body Fluids;cancer biomarkers;cancer care;cancer diagnosis;cancer risk;Categories;Classification;Clinical;clinically actionable;clinically relevant;Communities;Computational algorithm;Computing Methodologies;cost;Cost Savings;Decision Making;Detection;Development;Diagnosis;Diagnostic tests;Diagnostics Research;Disease;disease diagnosis;econometrics;Elements;Evaluation;experience;Formulation;Goals;high dimensionality;high risk;Image;improved;Individual;Indolent;Logic;Logistic Regressions;Machine Learning;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Medical;Methodology;Methods;Modeling;Motivation;multiplex diagnostics;National Cancer Institute;novel;overtreatment;Patient Care;Performance;personalized medicine;precision medicine;Predictive Value;Probability;Procedures;Property;prostate biopsy;PSA screening;Research;Screening for Prostate Cancer;simulation;Specificity;Statistical Methods;Statistical Models;statistics;Testing;Tissues;tool;Universities;user friendly software;Washington

PROJECT_TITLE: Analytic diagnosis methods for disease ruling

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Tuberous Sclerosis

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Public Health Relevance Statement:  Epilepsy affects ~1-2% of all people and is associated with increased mortality, as well as significant neurological morbidity, such as intellectual disability, autism, sleep disorders, and other neuropsychiatric manifestations. The grant aims to determine the role of a chloride transporter protein, KCC2, in causing epilepsy in Tuberous Sclerosis Complex (TSC), one of the most common genetic causes of epilepsy, and to develop novel therapeutic approaches for seizures in TSC and other epilepsies targeting this chloride transporter. Given the high prevalence of epilepsy in the general population, this research has strong relevance to public health and has the potential to have a significant positive impact in improving public health.

PI_NAMEs: WONG, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Adult;Affect;Applications Grants;autism spectrum disorder;Behavior Disorders;Biological Assay;Brain;Carrier Proteins;chloride-cotransporter potassium;Chlorides;Chronic;clinical application;clinical translation;Clinical Trials;clinically significant;Cognition Disorders;comorbidity;Data;Dependence;Development;Disabling;disease model;Drug resistance;Early treatment;effective therapy;Electroencephalography;Electrophysiology (science);Epilepsy;Epileptogenesis;FDA approved;FRAP1 gene;gamma-Aminobutyric Acid;General Population;Genetic;Genetic Diseases;Grant;Hamartoma;High Prevalence;Homeostasis;improved;Infantile spasms;inhibitor;innovation;Intellectual functioning disability;Knockout Mice;Late Effects;Life;Monitor;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;Neurologic;Neurologic Symptoms;neuronal excitability;Neurons;neuropsychiatric symptom;neuropsychiatry;novel;novel therapeutic intervention;novel therapeutics;Organ;Pathologic;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;prevent;Public Health;public health relevance;Quality of life;receptor;Regulation;Reporting;Research;response;Role;Seizures;side effect;Sleep Disorders;Specimen;synaptic inhibition;Testing;TSC1 gene;TSC2 gene;Tuberous Sclerosis;tumor growth;Western Blotting;Work

PROJECT_TITLE: KCC2 and epilepsy in a mouse model of tuberous sclerosis complex

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Infectious Diseases

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

PHR: Project Narrative This project aims to investigate the mechanisms by which RNA viruses manipulate chromatin dynamics and gene expression to enhance their replication. By unraveling these molecular processes, we can gain insights into how viruses exploit host cellular machinery, leading to the development of targeted antiviral strategies. Ultimately, this research holds promise for advancing our understanding of viral pathogenesis and improving public health outcomes.

PI_NAMEs: MAY, JARED PAUL (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Address;Affect;Alternative Splicing;ATAC-seq;Biogenesis;Bioinformatics;Biological Models;career;Cell Nucleolus;Cell Physiology;Chromatin;Cities;Cytoplasm;Data;Development;differential expression;Diffuse;DNA methylation profiling;Down-Regulation;Epigenetic Process;Event;experience;experimental study;Exposure to;fibrillarin;fitness;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene network;Genes;Goals;improved;Infection;insight;Kansas;Liquid substance;Maps;Measures;Mediating;Methylation;methylation pattern;Methyltransferase;Missouri;Modeling;Modification;Molecular;Mosaic Viruses;mRNA Precursor;mutant;Nicotiana;Nuclear;Nucleolar Proteins;Outcome;Pathway interactions;pea enation mosaic virus;Phase;Physical condensation;Plant Model;Plant RNA;Plant Viruses;Plants;Play;Process;protein expression;protein function;Protein Isoforms;Proteins;Public Health;Relaxation;Repression;Research;Research Personnel;Research Training;Ribosomes;RNA methylation;RNA Splicing;RNA Viruses;Role;Science;Severities;Shapes;skills;Small Nuclear RNA;Students;System;Techniques;Training;Training and Infrastructure;Transcript;transcriptome;transcriptome sequencing;undergraduate research experience;undergraduate student;Underrepresented Students;Universities;Up-Regulation;Viral;Viral Genes;Viral Pathogenesis;Viral Proteins;virology;Virus;Virus Diseases;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Modulation of host chromatin dynamics and gene expression by viral biomolecular condensates

STUDY_SECTION: VDT

STUDY_SECTION_NAME: Viral Dynamics and Transmission Study Section [VDT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE Hypertrophic cardiomyopathy (HCM) is an inherited disease characterized by thickening of the heart muscle that affects more than 600,000 Americans and frequently results in heart failure. By providing new knowledge about the mechanisms linking the gene defect to the development of the disease, this proposal opens avenues to treatment that could delay or abort transition of HCM to heart failure.

PI_NAMEs: LUPTAK, IVAN  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Affect;American;Anti-diabetic Drugs;Arrhythmia;ATP Hydrolysis;ATP Synthesis Pathway;Biological Assay;Calcium;Calcium ion;Carbon;Cardiac;Cardiac Myosins;Cardiovascular system;catalase;Cell Respiration;Characteristics;Chemicals;Clinical;clinical development;clinical phenotype;clinical translation;cost;Crossbreeding;Defect;Development;Disease;Disease Progression;Echocardiography;Electron Microscopy;energy balance;Excision;fatty acid oxidation;Free Energy;Functional disorder;Genes;Genetic;Glucose;glucose uptake;Glycolysis;Goals;Growth;Heart;Heart failure;heart function;hemodynamics;Hereditary Disease;Human;Hypertrophic Cardiomyopathy;Hypertrophy;Image;Impairment;improved;improved outcome;in vivo;inhibitor;inorganic phosphate;Intervention;Iodoacetamide;Knowledge;Label;Lead;Left Ventricular Hypertrophy;Link;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Mass Spectrum Analysis;Measurement;Measures;Mediating;Metabolic;metabolomics;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modification;Morbidity - disease rate;mortality;mouse model;multiple omics;Mus;Mutation;Myocardial;Myocardium;Myosin ATPase;Myosin Heavy Chains;Na(+)-K(+)-Exchanging ATPase;Nonmuscle Myosin Type IIA;Output;overexpression;oxidation;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Phosphorus;Play;Post-Translational Protein Processing;preference;prevent;Prevention;Process;Production;programs;Protein Biosynthesis;Proteins;Proteomics;Reactive Oxygen Species;Relaxation;Reporting;response;Risk;Role;Sampling;Sarcomeres;small molecule;Sodium;sodium ion;Stimulus;Structure;success;Sudden Death;Sulfhydryl Compounds;Testing;Time;tool;transcriptomics;Troponin T

PROJECT_TITLE: Targeting Energetics to Improve Outcomes in Hypertrophic Cardiomyopathy

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Kidney Disease;Orphan Drug;Precision Medicine;Rare Diseases;Transplantation

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE The overarching goal of this grant application is to gain a molecular understanding of the pathomechanism and a basic understanding of the immunological basis of anti-nephrin mediated podocyte injury, in order to guide personalized treatment of patients with diffuse podocytopathies and to identify pathways for novel targeted therapies.

PI_NAMEs: WEINS, ASTRID  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Acute;Adult;Algorithms;Allografting;Antibodies;Antibody titer measurement;Applications Grants;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Binding;Biopsy;Cells;Child;Clinical;clinical remission;cohort;Data;Development;Diagnostic;diagnostic tool;Diffuse;Disease;Disease Progression;Effector Cell;End stage renal failure;Ethics;Etiology;Experimental Animal Model;experimental study;Extracellular Domain;Focal and Segmental Glomerulosclerosis;Foot Process;Genetic;Glucocorticoids;Goals;Hospitalized Child;Human;Immunoglobulin G;Immunologics;Immunophenotyping;immunoregulation;Infection;Injury;Kidney;kidney allograft;kidney biopsy;Knowledge;Lead;Measles;Mediating;Molecular;Morphology;Mutation;nephrin;Nephrotic Syndrome;new therapeutic target;non-genetic;novel;Organ;Paper;Pathogenesis;Pathogenicity;Pathway interactions;patient subsets;Patients;personalized medicine;Plasmapheresis;podocyte;Proteinuria;Publishing;Recurrence;Recurrent disease;Relapse;Resistance;Role;Serum;slit diaphragm;Steroid-resistant idiopathic nephrotic syndrome;Steroids;Structure;Surface;targeted treatment;Testing;Therapeutic;Tissues;Transplantation;Treatment Failure;treatment response;treatment strategy;Virus Diseases

PROJECT_TITLE: Pathobiology of autoimmune-mediated diffuse podocytopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-W (05)]


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

ORG_STATE: NY

PHR: Project Narrative The proposed research is designed to investigate how Cyclin E1 regulates the IRF1 and type I interferon signaling pathway in ovarian tumor cells and how Cyclin E1 promotes pro-tumor polarization of macrophages and immunosuppression in the tumor microenvironment (TME) of ovarian cancer with Cyclin E1- amplification/overexpression. We will also develop potential therapeutic approaches for ovarian cancer with Cyclin E1-amplification/overexpression by targeting both tumor cell intrinsic oncogenic activity of Cyclin E1, as well as the immunosuppressive TME induced by Cyclin E1 overexpression. Preclinical evaluation of STING agonists in combination with CDK2 or ATR inhibitors in syngeneic and humanized mouse models will provide potentially effective treatment strategies for patients with Cyclin E1-amplified/overexpressing ovarian cancer. 1

PI_NAMEs: DING, LIYA  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: ATR gene;Binding;Biological Assay;BRCA deficient;BRCA mutations;Breast Cancer Treatment;cancer cell;Cancer cell line;Cancer Patient;CCNE1 gene;CCNE1 Gene Amplification;CDK2 gene;Cells;Cessation of life;Chemoresistance;chemotherapy;Chromatin;Clinical;Coculture Techniques;Combined Modality Therapy;Data;design;DNA;DNA Repair Pathway;Down-Regulation;effective therapy;Elements;Fostering;Gene Amplification;Genes;Genetic Transcription;homologous recombination;homologous recombination deficiency;Human;humanized mouse;Immune;Immunomodulators;Immunoprecipitation;immunoregulation;Immunosuppression;In Vitro;in vivo;inhibitor;inhibitor therapy;Interferon alpha;Interferon Type I;IRF1 gene;knock-down;Macrophage;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Molecular;mouse model;Mus;mutant;neoplastic cell;novel strategies;novel therapeutics;Oncogenic;Outcome;Ovarian;ovarian neoplasm;overexpression;PARP inhibition;patient derived xenograft model;Patients;Phosphotransferases;Play;Poly(ADP-ribose) Polymerase Inhibitor;Population;Pre-Clinical Model;preclinical evaluation;Process;Prognosis;promoter;protein expression;Regimen;Regulation;Reporting;Research;response;Role;Sampling;Serous;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Specimen;STING agonists;System;targeted treatment;Therapeutic;therapeutic target;therapy resistant;transcriptome sequencing;Treatment Efficacy;treatment strategy;Treatment-related toxicity;tumor;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;Validation;Women's mortality

PROJECT_TITLE: The Immunomodulatory Function of Cyclin E1 in Ovarian Cancer and Therapeutic Targeting

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Chronic Mycobacterium avium complex (MAC) pulmonary disease is an increasingly common orphan disease that causes progressive disability in older adults and has a tremendous unmet therapeutic need. We seek to conduct analytic and clinical validation of a CRISPR-based blood test for MAC cell-free DNA as a measure of MAC pulmonary disease activity and treatment response. This biomarker could ultimately be used to guide diagnostic and therapeutic decision-making with regard to MAC pulmonary disease.

PI_NAMEs: HU, TONY Y.;WINTHROP, KEVIN LORING (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Acid Fast Bacillae Staining Method;Affect;Aging;anti-microbial drug;Antibiotics;antimicrobial;Antimycobacterial Agents;Bacillus;biobank;Biological;Biological Assay;Biological Markers;Biological Response Modifier Therapy;Blood specimen;Blood Tests;Bronchoscopy;cell free DNA;Cells;Chimera organism;Chronic;Clinic;Clinical;Clinical Trials Network;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;comorbidity;Data;Decision Making;Detection;Diagnosis;Diagnostic;diagnostic assay;disability;Disease;DNA;Elderly;Enrollment;Evaluation;Exposure to;Genus Mycobacterium;Guidelines;health related quality of life;improved;Individual;Infection;Laboratories;Lung;Lung Diseases;Lung infections;Measurement;Measures;meetings;Methods;Monitor;Mycobacterium avium;Mycobacterium avium Complex;Mycobacterium intracellulare;Mycobacterium tuberculosis;Non-Invasive Detection;non-tuberculosis mycobacteria;novel;older adult;Organism;Outcome;participant enrollment;pathogen;Patient Outcomes Assessments;patient population;patient subsets;Patients;Pharmacotherapy;Population;portability;Pragmatic clinical trial;Prevalence;Procedures;Production;prospective;Prospective cohort;Radiation;radiological imaging;rapid detection;rapid diagnosis;Rare Diseases;Recommendation;Recording of previous events;Recurrence;Recurrent disease;Relapse;Reporting;Reproducibility;Residual Neoplasm;respiratory;response;Retrospective cohort;Sampling;Scanning;Sensitivity and Specificity;Serum;Severity of illness;Soil;Sputum;symptomatic improvement;Symptoms;Technology;Testing;Therapeutic;Treatment Efficacy;treatment guidelines;treatment response;trend;Tuberculosis;Tuberculosis diagnosis;Validation;Water;Woman;X-Ray Computed Tomography

PROJECT_TITLE: CRISPR detection of circulating cell-free Mycobacterium avium complex (MAC) DNA for rapid diagnosis and monitoring of MAC pulmonary disease

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Neurosciences;Pediatric

ORG_NAME: UNIVERSITY OF MASSACHUSETTS BOSTON

PHR: NARRATIVE Combining behavioral and neurophysiological methods, we propose to investigate the development of the strategic use of working memory resources in children during a period right after school entry (from 6 to 7 years of age, longitudinally) when children are first formally faced with cognitive tasks that require memorization. Understanding strategic working memory use in children has important potential implications for educational psychology. Our paradigm is also well suited for systematic comparisons between typically and atypically developing children (e.g. those diagnosed with ADHD).

PI_NAMEs: BLASER, ERIK ;KALDY, ZSUZSANNA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 7 year old;Address;Adopted;Adult;age related;Area;Attention deficit hyperactivity disorder;Award;Back;behavior prediction;Behavioral;Boston;Characteristics;Child;Child Development;Cognitive;cognitive control;cognitive task;cognitive testing;cohort;Computer Models;cost;Development;Diagnosis;Economics;Educational Psychology;Environment;Equilibrium;Exertion;Feedback;flexibility;Friends;Goals;graduate school preparation;Head;improved;Incentives;Individual;innovation;insight;International;Link;Longitudinal Studies;Measures;member;Memory;Mentorship;Methods;Mission;Modeling;Mydriasis;neurophysiology;Participant;Peer Review;Performance;Pilot Projects;Population Heterogeneity;Process;Psyche structure;Psychophysics;Publications;Recipe;Research Design;Research Personnel;Resources;response;Sampling;Schools;Short-Term Memory;skills;Sorting;Standardization;Students;success;symposium;Tablets;Telephone;Testing;Time;Time Study;Training;undergraduate student;United States National Institutes of Health;Variant;virtual;Visual;Work

PROJECT_TITLE: The development of the trade-off between sampling and remembering the visual world

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BLACKSBURG

ORG_DEPT: NEUROSCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Encoding and consolidating memories requires coordination of spiking activity in populations of pyramidal neurons in the hippocampus. Axo-axonic and basket cell interneurons are hypothesized to have an essential role in hippocampal circuits, but their physiological functions in supporting spatial memory formation in behaving animals have remained poorly understood. Here we determine the role of these interneurons in coordinating pyramidal neurons during network oscillations supporting spatial memory formation.

PI_NAMEs: ENGLISH, DANIEL FINE (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TITLE: Functions for CA1 axo-axonic and basket interneurons in sharp-wave ripple replay and spatial memory

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Infectious Diseases;Nanotechnology

ORG_CITY: DETROIT

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Eye surgeries increase the risk of infections like bacterial endophthalmitis. As age-related eye diseases become more prevalent, the number of elderly patients needing surgery is rising, resulting in a proportional increase in endophthalmitis cases. This study aims to investigate the role of ferroptosis, a type of programmed cell death, and determine whether it can be targeted for the treatment of bacterial endophthalmitis and other ocular infections.

PI_NAMEs: KUMAR, ASHOK  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Affect;Age;age related;Anti-Inflammatory Agents;Antibiotics;Antioxidants;antiporter;Apoptosis;Attenuated;Bacteria;bacterial endophthalmitis;Blindness;Butyrates;Cell Death;Cell Death Induction;Cells;Coenzyme A Ligases;Communicable Diseases;Complement;Complication;Cultured Cells;Cystine;Data;Deferoxamine;Development;Down-Regulation;Endophthalmitis;Enzymes;Exhibits;Eye diseases;Eye Infections;Eye Injuries;Family member;Funding;gene therapy;Glutamates;glutathione peroxidase;Goals;Hydroxyeicosatetraenoic Acids;Impairment;improved outcome;Infection;infection risk;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innate Immune Response;insight;Intervention;intravitreal injection;Iron;Iron Chelation;Iron Overload;Knockout Mice;Knowledge;Link;lipid mediator;Lipid Peroxidation;Lipid Peroxides;lipidomics;Mediating;Mediator;Metabolism;metabolomics;mouse genetics;Mus;nanoformulation;nanoparticle;novel strategies;novel therapeutic intervention;older patient;Operative Surgical Procedures;Ophthalmologic Surgical Procedures;Oxidative Stress;pathogen;Patients;pharmacologic;Play;Predisposition;preservation;prevent;Property;Reduced Glutathione;Regulation;Research;Resolution;response;Retina;Risk;Role;Selenium;Severities;Signal Transduction;Staphylococcus aureus;Staphylococcus aureus infection;System;targeted treatment;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Tissues;tool;transcriptomics;Transgenic Mice;Vancomycin;Vision;Work

PROJECT_TITLE: Ferroptosis in bacterial endophthalmitis: Mechanisms and Therapeutic targeting

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative (3 sentences) Black and Latino(a/x) children experience worse hospital outcomes that is in part due to lower quality communication between their clinicians and caregivers (parents and guardians). With the input of Black and Latino(a/x) caregivers as well as clinicians that care for children in the hospital, we will develop, refine, and test an equity focused communication intervention that gives clinicians skills for more equitable communication. This research has the potential to reduce child health inequities through improved patient and family-centered care in the hospital.

PI_NAMEs: PARENTE, VICTORIA  (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: acceptability and feasibility;Admission activity;Adverse event;adverse outcome;arm;Award;Behavior;Black race;career;career development;Caregivers;Caring;Child;Child Care;Child Health;Childhood;Clinical;clinical encounter;Clinical Trials;Clinical Trials Design;Code;Communication;communication behavior;Data;Data Collection;design;Disparity;Educational process of instructing;efficacy outcomes;Elements;empowerment;Enrollment;Environment;Equity;ethnic difference;Evidence based practice;experience;Family;feasibility testing;Feedback;Goals;group intervention;Health;health disparity;health equity;Health equity research;health inequalities;Hospital Costs;hospital readmission;Hospitalization;Hospitalized Child;Hospitals;implementation barriers;improved;Inequity;Inpatients;Intervention;intervention effect;intervention refinement;Intervention Trial;Interview;Justice;K-Series Research Career Programs;Knowledge;Language;Latino;Length of Stay;Linguistics;Manuals;Medical Errors;Mentorship;Modeling;mortality;Outcome;Outcome Measure;Parents;Patients;Positioning Attribute;preference;primary outcome;programs;Protocols documentation;provider communication;racial difference;Racial Equity;Randomized;readmission rates;recruit;Research;Research Personnel;Risk;skills;standard of care;Statistical Models;Structure;Surgical complication;Surveys;Testing;therapy development;treatment arm;Treatment Efficacy;two-arm trial;United States National Institutes of Health;uptake;Waiting Lists;Work

PROJECT_TITLE: Equity Focused Communication Intervention for Family-Centered Rounds

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (J1)]


NIH_SPENDING_CATS: Biotechnology;Chronic Obstructive Pulmonary Disease;Genetics;Human Genome;Lung;Prevention;Tobacco;Tobacco Smoke and Health

PHR: Project Narrative The roles of the many of the susceptibility genes that have been associated with chronic diseases are not understood. The present study will identify genetic variants that modulate cigarette smoke-induced gene expression in primary airway epithelial cells from 185 individuals. The role of the genes that colocalize with genetic variants associated with COPD susceptibility will be further investigated as gene candidates responsible for initiating COPD development. Therefore, these studies will help identify novel biological processes that drive the development of COPD, and may be useful biomarkers for COPD subtypes.

PI_NAMEs: CASTALDI, PETER ;TESFAIGZI, YOHANNES  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: ACVR1B gene;Affect;airway epithelium;Anti-Inflammatory Agents;Antibodies;Arginine;Basal Cell;BCL2 gene;Biological Markers;Biological Process;Candidate Disease Gene;causal variant;Cell Death Induction;cell type;Cells;Chronic;Chronic Disease;Chronic Obstructive Pulmonary Disease;cigarette smoke;cigarette smoke-induced;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;Collection;Complex;Data;Dendritic Cells;Development;differential expression;Disease;Disease susceptibility;disorder subtype;early detection biomarkers;Early Diagnosis;effective therapy;Endothelial Cells;Epithelial Cells;Epithelium;Exposure to;exposure to cigarette smoke;Fibroblasts;former smoker;Future;gain of function;Gene Expression;Genes;genetic selection;genetic variant;genome wide association study;genome-wide;genomic locus;Genotype;Human;human data;human female;Hyperplasia;in vivo;Individual;Inflammatory;Injury;Investigation;Link;link protein;loss of function;Lung;male;Mediating;Membrane;Molecular;Mucin 1 protein;Mucins;Mucous body substance;Nose;novel;novel therapeutic intervention;Obstructive Lung Diseases;Outcome;Pathogenesis;Pathway interactions;patient stratification;Phenotype;pollutant;Population;Predisposition;Process;Proline;Proline-Rich Domain;protein expression;Protein Family;Proteins;Proteomics;pulmonary function;Quantitative Trait Loci;Regulation;Resolution;Resources;response;RNA;RNA Sequences;Role;Scanning;Single Nucleotide Polymorphism;single-cell RNA sequencing;Small Interfering RNA;Smoker;Squamous Cell;Squamous Differentiation;Structure of parenchyma of lung;Susceptibility Gene;T-Lymphocyte;Testing;TP53 gene;trait;transcription factor;transcriptome sequencing;Tretinoin;Variant;Whole Blood;whole genome

PROJECT_TITLE: Genetic variants that affect the airway epithelium to drive obstructive lung disease

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Nutrition;Obesity;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Congenital malformations represent a significant public health challenge, contributing to a large fraction of infant mortalities and morbidities. While these conditions are often linked to metabolic dysfunctions such as diabetes and obesity, we still have a superficial understanding of how non-genetic factors modulate the development of tissues and organs. Defining how metabolism is integrated with the genetic programs that control embryogenesis will allow for better prevention, diagnosis, and management of developmental disorders.

PI_NAMEs: SIMOES-COSTA, MARCOS  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Acetylation;aerobic glycolysis;Affect;Biological Assay;blood glucose regulation;cell motility;Cell Shape;cell type;Cells;Cleavage Under Targets and Release Using Nuclease;Complex;Congenital Abnormality;Coupled;Data;Deposition;Development;Developmental Biology;developmental disease;Diabetes Mellitus;Diagnosis;Elements;embryo cell;Embryonic Development;embryonic stem cell;Endowment;Enhancers;epidemiology study;Epigenetic Process;epigenome;epigenomics;epithelial to mesenchymal transition;Etiology;experimental study;functional genomics;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene regulatory network;Genes;Genetic;Genetic Determinism;Genetic Transcription;Genome;Genome engineering;genome-wide;genomic locus;Genomics;glucose metabolism;Glycolysis;Histones;Homeostasis;Incidence;infant morbidity/mortality;Infant Mortality;insight;Link;Maintenance;Measures;Metabolic;Metabolic Control;Metabolic dysfunction;Metabolism;migration;Molecular;Neural Crest;Neural Crest Cell;non-genetic;novel;Nucleic Acid Regulatory Sequences;Obesity;Organ;Output;Pattern;perinatal outcomes;pharmacologic;Predisposition;Prevention;programs;Property;Proteins;Public Health;Regulation;Regulatory Element;Reporter Genes;response;Risk;Role;Shapes;Stem Cell Development;stem cells;stemness;Testing;Therapeutic Intervention;Tissues;transcriptomics;Transferase;Warburg Effect

PROJECT_TITLE: Metabolic control of the neural crest epigenome

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOLOGY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: Public Health Relevance Statement The research seeks to develop super-resolution imaging technologies that allow for versatile nanoscale imaging of biological specimens such as cells and tissues. This would enable profiling of how biomolecules are spatially organized in healthy and disease states, and discovery of new therapeutic targets.

PI_NAMEs: MIN, WEI ;WATSON, ALAN MICHAEL;ZHAO, YONGXIN  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: 3-Dimensional;Acceleration;Animals;Antigens;Axon;Biological;biological systems;Brain;Carbohydrates;Cell Nucleus;cell type;Cells;Chemistry;Color;Complex;confocal imaging;Data Set;deep learning;Detection;Disease;DNA;Dyes;Ensure;Epitopes;experimental study;Fluorescence Microscopy;Fostering;Gel;Health Status;Hydrogels;Image;image processing;imaging modality;imaging system;Imaging technology;improved;Incubated;insight;Label;Life;Light Microscope;Link;Lipids;Location;Machine Learning;Maps;Metabolic;metabolic imaging;Methods;Microscopy;Mitochondria;Molecular;nanoscale;Nervous System;Neurosciences;new therapeutic target;next generation;Noise;novel;novel strategies;Nucleic Acids;Oncology;Organ;Organelles;Organism;Pattern;Periodicity;Polymers;premature;preservation;Process;Proteins;Proteomics;Protocols documentation;public health relevance;Raman Spectrum Analysis;Reagent;Research;Resolution;Sample Size;Shapes;Specimen;Speed;Stains;superresolution imaging;Synapses;System;Techniques;Technology;Testing;Texture;Thick;Tissue Expansion;Tissue imaging;Tissues;tool;tumor microenvironment;ultra high resolution;Visualization;Water;Whole Organism;Work

PROJECT_TITLE: Next generation biomolecule-retention expansion microscopy for diverse imaging applications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (82)]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: WORCESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE This project will develop and test a training program in Motivational Interviewing Adapted for Vaccination (MI- VAX) for primary care providers (PCPs) to support their promotion of COVID-19 and influenza vaccination among vulnerable populations. The evidence generated by this study will be crucial to mitigating the health disparities resulting from the current COVID-19 pandemic and to reducing the unnecessary burden of preventable COVID-19 and influenza disease.

PI_NAMEs: FISHER, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Address;Adult;behavior change;Caring;Cessation of life;Childhood;Clinical;Cluster randomized trial;Communication;COVID-19;COVID-19 burden;COVID-19 disparity;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;Development;Disease;Disparity;ethnic minority;ethnic minority population;Ethnic Origin;evidence base;experience;Federally Qualified Health Center;Feedback;Foundations;global health;Goals;Health behavior;health disparity;Health Personnel;Healthcare;Healthcare Systems;Hospitalization;implementation science;Individual;Influenza;Influenza vaccination;influenza virus vaccine;innovation;Intervention;low socioeconomic status;Minority Groups;motivational enhancement therapy;novel;outcome disparities;Patient Care;patient oriented;patient-clinician communication;Patients;Physicians;Play;Population;Population Heterogeneity;Positioning Attribute;Pragmatic clinical trial;primary care clinic;primary care provider;primary outcome;Professional Organizations;Provider;Race;racial minority population;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reduce health disparities;Research;respiratory;response;Role;Series;skills;socioeconomic disadvantage;Socioeconomic Status;System;Testing;Training;Training Programs;United States;Update;uptake;Vaccination;vaccine acceptance;vaccine hesitancy;Vaccines;video module;Viral;Vulnerable Populations;Work;World Health Organization

PROJECT_TITLE: Motivational Interviewing Training to Promote COVID-19 and Influenza Vaccination (MI-VAX): What Providers Need and Patients Want

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Hematology;Lung;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE We will evaluate the premise that airway instillation of bone marrow-derived monocytes of mice, or of human monocytes, enhances host resilience by increasing gap junctional communication between the monocytes and the alveolar epithelium. We expect the underlying mechanism to be activation to specific kinases by calcium communication through the gap junctions. The expected overall outcome is to augment host resilience against ALI/ARDS by a novel monocyte instillation therapy in the lung.

PI_NAMEs: BHATTACHARYA, JAHAR  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;adenylate kinase;Alveolar;alveolar epithelium;Alveolar Macrophages;Alveolus;Anti-Inflammatory Agents;Bacteria;Biological Assay;Blood;Bone Marrow;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;Calmodulin-Binding Proteins;Cell Therapy;Cells;Communication;Confocal Microscopy;Connexin 43;Data;Epithelium;experimental study;follow-up;Frequencies;gap junction channel;Gap Junctions;Gene Modified;Gram-Negative Bacteria;Heterogeneity;Human;Inflammatory;interest;knock-down;Knock-out;Lavage;Lipopolysaccharides;Lung;lung imaging;monocyte;mortality;mouse model;Mus;Myelogenous;Myeloid Cells;NF-kappa B;novel;opportunistic pathogen;Outcome;Pattern;Phosphorylation;Phosphotransferases;promote resilience;protective effect;Pseudomonas aeruginosa;Pulmonary Inflammation;real-time images;Reporting;Research;resilience;resilience factor;response;Role;sex;Signal Transduction;Slice;Structure of parenchyma of lung;Testing;Time;transmission process

PROJECT_TITLE: Induction of myeloid-epithelial gap junctional channels to enhance host resilience against acute lung injury.

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Lung;Organ Transplantation;Regenerative Medicine;Transplantation

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY HEALTH NETWORK

ORG_STATE: ON

ORG_ZIPCODE: M5G 2C4

PHR: Project Narrative Lung transplant recipients have low survival rates because their immune system rejects the donor lung. Our project will use new CRISPR genome editing technologies to modify the genetic composition of donor lungs and make them better tolerated in transplant patients. Our studies will enable transplant recipients to live healthy and fulfilling lives without the need for lifelong medication or the fear of organ rejection.

PI_NAMEs: KESHAVJEE, SHAF  (contact);KLEINSTIVER, BENJAMIN PETER

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: Achievement;Adoption;Anti-Inflammatory Agents;Antigen-Presenting Cells;base editing;base editor;Body Temperature;Breathing;Caring;Cell Therapy;Cells;Chronic;Clinical;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Combined Modality Therapy;CRISPR/Cas technology;cytokine;design;Development;Disease;efficacy evaluation;Engineering;Exposure to;extend lifespan;Family suidae;Flow Cytometry;Fright;Functional disorder;Future;gene editing technology;Gene Modified;gene therapy;gene-editing approach;General Hospitals;Genes;Genetic;Genome;genome editing;Goals;graft dysfunction;graft function;Graft Rejection;Graft Tolerance;Health;Hour;Human;IL10 gene;Immune system;immunoengineering;immunoregulation;Immunosuppression;improved;in vivo;in vivo Model;Infection;Inflammatory;Injury;interdisciplinary approach;interest;Interleukin-10;Interleukin-10 Overexpression;Intervention;Leadership;Life;Lung;lung allograft;Lung Diseases;lung preservation;Lung Transplantation;Malignant Neoplasms;Massachusetts;Measures;Mediating;Modeling;Modification;Monitor;North America;novel;novel strategies;novel therapeutics;Nutrient;Organ;Organ Donor;organ transplant rejection;Organ Transplantation;Outcome;Oxygen;Patient-Focused Outcomes;Patients;Perfusion;Pharmaceutical Preparations;Physiological;Positioning Attribute;post-transplant;pre-clinical;prevent;Procedures;Process;Protocols documentation;Quality of life;Quantitative Reverse Transcriptase PCR;Regulatory T-Lymphocyte;repaired;Research;Resistance;Resources;Risk;Role;Safety;Site;skin xenograft;somatic cell gene editing;success;Survival Rate;synergism;System;Tacrolimus;Technology;Testing;Therapeutic;therapeutic genome editing;Time;Transcript;translational study;transplant model;Transplant Recipients;Transplantation;Transplantation Tolerance;United States National Institutes of Health;Universities;Up-Regulation;Viral Vector;Work;Xenograft Model

PROJECT_TITLE: Immunoengineering of donor lungs to optimize long-term graft function

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Estrogen;Neurosciences;Prevention;Substance Misuse;Substance Misuse Prevention;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: The objective of this proposal is to define and understand the neural basis of estrogenic regulation of binge drinking in both females and males. By doing so, we hope to gain valuable insights into the mechanisms behind the estrogenic regulation of alcohol drinking. Ultimately, this will help us develop more effective prevention and treatment strategies.

PI_NAMEs: XU, PINGWEN  (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Affect;Agonist;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol misuse;alcohol prevention;alcohol reward;alcohol sensitivity;alcohol use disorder;Alcohols;Attenuated;binge drinker;binge drinking;Brain;Brain region;Cell Nucleus;Chronic;Consumption;Data;Dopamine;Dorsal;drinking behavior;effective therapy;ESR1 gene;Estradiol;estrogenic;Estrogens;Female;Fiber;Functional disorder;Genes;Genetic;Grant;Heavy Drinking;Human;Impaired cognition;in vivo;individualized medicine;insight;male;Maps;Measures;Mediating;men;Mental disorders;Modeling;Monitor;mouse model;mRNA Expression;Mus;neural;neural circuit;Neurons;novel;optogenetics;Ovarian hormone;Ovariectomy;patch clamp;Pattern;Peripheral Nervous System Diseases;Photometry;Population;Premenopause;Prevention strategy;receptor;Regulation;response;Rodent;Role;Serotonergic System;Serotonin;sex;Sex Differences;sexual dimorphism;Signal Transduction;Source;Supplementation;System;Testing;treatment strategy;Ventral Tegmental Area;Woman

PROJECT_TITLE: Doral raphe 5-HT neurons mediating estrogenic regulation of binge drinking

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The NIA Interventions Testing Program (ITP) represents a multi-site translational research program that tests drugs to see if they increase healthy lifespan in mice as an effective way to discover interventions that may benefit human aging. The work of the ITP 1) yields new insights into the control of aging, aging rate, and age- associated diseases that facilitate the eventual development of agents that could be of benefit in preventive geriatric medicine; and 2) potentially identifies health dangers of unproven treatments that are purported to have anti-aging actions, which will also have public health benefits.

PI_NAMEs: SALMON, ADAM  (contact);STRONG, RANDY

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: Acarbose;Adult;Age;age related;age-related disease;Aging;aging mechanism;anti aging;Application procedure;astaxanthine;Beds;Biological Availability;Biological Specimen Banks;Biology of Aging;Blood;Captopril;Cause of Death;Collaborations;Communities;comparative;Data;Data Coordinating Center;data management;Data Pooling;Data Set;Development;Diagnostic Specificity;Disease;Dose;Drug Kinetics;drug testing;Elements;end of life;Estradiol;Evaluation;experimental study;extend lifespan;Food;Gene Expression;Geriatrics;Glycine;Goals;Health;Health Benefit;healthspan;Histopathology;Human;insight;interest;International;Intervention;intervention effect;Laboratories;late life;Life;life span;Link;Longevity;Mammals;meetings;member;Metabolism;Methods;Michigan;middle age;Molecular;Mus;New Agents;old mice;Organ;Outcome;Pathologic;Pathology;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacology;Physiological;preservation;Preventive;Procedures;programs;Protocols documentation;Public Health;Publications;rate of aging;Reproducibility;Research;response;Schedule;Scientist;sex;Sex Differences;Sirolimus;Site;small molecule;Specific qualifier value;Specimen;Standardization;Testing;Texas;tissue archive;tissue preparation;Tissues;Transcript;transcriptome sequencing;transcriptomics;translational research program;transmission process;Universities;web site;Work

PROJECT_TITLE: Center for Testing Potential Anti-Aging Interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (J1)]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

ORG_DEPT: DENTISTRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Trypanosoma brucei is a unicellular parasite responsible for devastating diseases that affect some of the most marginalized populations. Mitochondrial RNA processing reactions catalyzed by terminal RNA uridylyl transferases are required for the parasite’s survival. Therefore, the proposed studies will expand the knowledge of essential biological processes and uncover new targets to combat this clinically significant pathogen.

PI_NAMEs: AFASIZHEV, RUSLAN  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Accountability;Affect;Africa South of the Sahara;Anti-sense RNA;Antigenic Variation;Basic Science;Binding;Biogenesis;Biological Process;Biology;Catalytic Domain;Chemistry;clinically significant;Code;Collaborations;combat;Complex;crosslink;Cryoelectron Microscopy;Dedications;Development;Disease;Docking;Enzymes;epitranscriptomics;Eukaryota;Exonuclease;fly;Foundations;Generations;Genome;Guide RNA;helicase;human pathogen;Hydrolysis;Image;in vivo;Individual;insertion/deletion mutation;insight;Knowledge;Link;loss of function;Mammals;Maps;marginalized population;Mass Spectrum Analysis;Maternal Messenger RNA;Messenger RNA;Metabolic;MicroRNAs;Minor;Mitochondria;Mitochondrial RNA;Modality;Modernization;Modification;Molecular;Molecular Motors;Parasites;Parasitic infection;particle;pathogen;Pathway interactions;Phosphodiesterase I;Process;Production;protein complex;Proteomics;Protozoa;Public Health;Reaction;Resolution;Resources;Ribonucleoproteins;Ribosomal RNA;RNA;RNA Decay;RNA Editing;RNA Helicase;RNA metabolism;RNA Processing;Roentgen Rays;Role;Site;structural determinants;Structure;Tail;Technology;Testing;Trans-Splicing;Transcript;Transfer RNA;Transferase;Translations;Trypanosoma;Trypanosoma brucei brucei;uridylate;Work

PROJECT_TITLE: Mitochondrial RNA Uridylation in Trypanosomes

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Type 2 diabetes is known as a disease of abnormal glucose metabolism, but people with diabetes also have alterations in amino acid utilization as well. The reasons why this occurs are incompletely understood. The goal of this project is to determine how a key enzyme in amino acid metabolism is regulated and how the activity of this enzyme is altered in obesity and diabetes.

PI_NAMEs: FINCK, BRIAN N (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Affect;Alleles;amino acid metabolism;Amino Acids;Binding;Biochemical;blood glucose regulation;Branched-Chain Amino Acids;branched-chain-amino-acid transaminase;Catabolism;Clustered Regularly Interspaced Short Palindromic Repeats;Cultured Cells;Data;design;Development;Diabetes Mellitus;diabetic;Dietary intake;dietary restriction;Disease;enzyme activity;Enzymes;Event;Future;Genetic;Genetic Variation;genome wide association study;glucose metabolism;Goals;Hepatic;Homeostasis;Human;Impairment;improved;In Vitro;in vivo;Insulin Resistance;insulin sensitivity;Isoleucine;Keto Acids;Knock-in;Lead;Leucine;Link;Lipids;Liver;Mediating;Metabolic;Metabolic Diseases;Metabolism;mimetics;Mitochondrial Matrix;Modification;Molecular;Multienzyme Complexes;Mus;mutant;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;oxidation;Oxidoreductase;Pathway interactions;PDH kinase;Persons;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Plasma;Play;prevent;Protein Biosynthesis;Protein Dephosphorylation;Protein phosphatase;Proteins;Proteolysis;Proteomics;Rattus;Regulation;response;Risk;Rodent;Rodent Model;Role;Serine;Testing;Therapeutic;Tissues;Valine;Viral Vector

PROJECT_TITLE: Covalent regulation of branched chain amino acid metabolism

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Aging progressively impairs cardiac function, especially diastolic function, leading to lower quality of life and increased susceptibility to cardiovascular disease. This study will determine the regulation of mitochondrial NAD+ levels and the role of mitochondrial NAD+ transporter SLC25A51 in cardiac aging. The findings will provide novel insights for developing mitochondrial-targeted therapeutics to improve mitochondrial NAD+ metabolism and treat age- related diastolic dysfunction.

PI_NAMEs: CHIAO, YING ANN  (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Acceleration;adeno-associated viral vector;Affect;age related;age related changes;age related decline;age-related disease;Aging;aging related;Attention;Cardiac;cardiac aging;Cardiovascular Diseases;Chronic;Clinical Trials;cofactor;Consumption;Cytosol;Data;Deacetylation;Disease;Down-Regulation;Energy Metabolism;Functional disorder;Genetic;Glycolysis;Heart;Heart Diseases;heart function;Heart Research;Impairment;improved;in vivo;insight;Intervention;Isotope Labeling;Kinetics;knock-down;Knock-in Mouse;Knock-out;Knowledge;Literature;Mammalian Cell;Mediating;Membrane Potentials;Metabolic;Metabolism;metabolome;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;mitochondrial metabolism;Mitochondrial Proteins;mitochondrial therapeutics;Modeling;mouse model;Mus;Myocardial dysfunction;Nicotinamide adenine dinucleotide;novel;novel strategies;old mice;Organ;overexpression;Oxidation-Reduction;Phenotype;Pilot Projects;preclinical study;Predisposition;protective effect;Protein Acetylation;Proteins;Publishing;Quality of life;Regulation;Research Personnel;Respiration;Role;Signal Transduction;Sirtuins;Supplementation;Testing;Therapeutic;Time;tool;Tracer;Wild Type Mouse;Work

PROJECT_TITLE: Mitochondrial NAD+ Metabolism in Cardiac Aging

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Physical Activity

ORG_CITY: ORLANDO

ORG_NAME: ADVENTHEALTH ORLANDO

ORG_STATE: FL

PHR: Project Narrative Obesity, characterized by excess white adipose tissue, has become increasingly prevalent in the United States, and is a global health and economic problem. The quality and function of adipose tissue are an important link between obesity and the pathogenesis of numerous metabolic diseases, including Type 2 Diabetes, Metabolic Syndrome and cardiovascular disease; yet, the impact of health improvement strategies, such as exercise, on the quality and underlying biological properties of adipose tissue are poorly understood. The proposed research is relevant to public health because it will provide new insights into how exercise can turn “unhealthy” adipose tissue into “healthy” adipose tissue, which can greatly influence whole body health and metabolism in humans.

PI_NAMEs: SPARKS, LAUREN MARIE (contact);WHITE, URSULA

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Abdomen;Adipocytes;Adipose tissue;Biological;Biology;Body Weight Changes;Body Weight decreased;Cardiovascular Diseases;Cell Nucleus;Cells;Closure by clamp;Deuterium;DNA;Economics;endurance exercise;Exercise;Fasting;Fatty acid glycerol esters;Future;global health;Health;Human;Hyperinsulinism;Immune;Immunohistochemistry;improved;in vivo;Inflammation;innovation;insight;Insulin;Insulin Resistance;Intervention;Isotope Labeling;Label;Link;lipid biosynthesis;Lipolysis;Maintenance;men;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolic syndrome;Metabolism;Methods;Microdialysis;molecular phenotype;Mus;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Obesity;Oral;Pathogenesis;Physiological;Play;Premenopause;Property;Prospective Studies;Protocols documentation;Public Health;Publishing;Randomized Controlled Clinical Trials;Research;response;Role;senescence;senescent cell;single nucleus RNA-sequencing;stem cells;subcutaneous;Tissues;Training;transcriptomics;Triglycerides;United States;Woman

PROJECT_TITLE: Adipogenesis, triglyceride turnover and cellular composition of adipose tissue in response to endurance training (ATLAS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-D (02)]


ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Microbial-based cancer therapies have the potential to activate both innate and adaptive arms of the immune system to promote effective cancer immunotherapy. However, a better understanding of the interactions between intracellular bacteria and cancer is required to harness the microbe’s full potential. Here we will test our hypothesis using an attenuated (DactA) strain of Listeria monocytogenes as a therapeutic cancer vaccine that can act both systemically to promote an adaptive CD8+ T cell response as well as locally within tumors to unleash CD8+ T cell activity by providing innate immune stimuli that reverses Treg-mediated immunosuppression.

PI_NAMEs: DUPAGE, MICHEL ;PORTNOY, DANIEL A (contact)

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: adaptive immunity;Address;Adoptive Transfer;Affect;Agonist;anti-cancer;Antibodies;antigen-specific T cells;Antineoplastic Agents;Area;arm;Attenuated;Automobile Driving;Bacteria;Bar Codes;Bystander Effect;Cancer Control;cancer immunotherapy;cancer infiltrating T cells;Cancer Model;Cancer Patient;cancer therapy;Cancer Vaccines;CD34 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;cell type;Cells;Clinical;Clinical Trials;Collaborations;cytokine;Cytosol;Data;Dose;engineered T cells;Engineering;Excision;experience;FOXP3 gene;Generations;Goals;Growth;humanized mouse;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immunization;Immunize;Immunosuppression;Immunotherapy;in vivo;inflammatory milieu;Injections;Interferon Type II;Interleukin-2;Intravenous;intravenous injection;Kinetics;Knowledge;Libraries;Lipoproteins;Listeria monocytogenes;Liver;Malignant Neoplasms;Mediating;Microbe;microbial;migration;Mus;Natural Immunity;Nature;neoantigens;neoplastic cell;novel strategies;Outcome;Patients;Peptides;Phagosomes;Phase;Phenotype;Population;pre-clinical;Production;Productivity;Property;Recombinants;Regimen;Regulatory T-Lymphocyte;Reporter;response;Role;Route;sensor;Shapes;Signal Transduction;Site;Solid Neoplasm;Spleen;Stimulus;success;T cell response;T cell therapy;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapeutic vaccine;TLR2 gene;trafficking;transmission process;tumor;Tumor Antigens;Tumor Burden;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Volume;vaccine trial;Work

PROJECT_TITLE: Reversing cancer immunosuppression using attenuated Listeria monocytogenes

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative. Improper gene expression is a hallmark of cancer, and many oncogenes encode mutated transcription activators or co-activators. The goal of this project is to better understand how these transcription factors function by applying new single molecule technology. This understanding will be essential for designing treatments and drugs to restore normal gene expression in diseased cells.

PI_NAMEs: BURATOWSKI, STEPHEN  (contact);GELLES, JEFF

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Address;Affect;Behavior;Binding;Binding Sites;Biochemical;Biological Models;cancer cell;Cells;Characteristics;Chromatin;Color;Complement;Complex;Disease;DNA;DNA Binding Domain;Engineering;Enhancers;Eukaryota;Event;experience;experimental study;Face;Fluorescence;follow-up;Frequencies;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genomics;Glean;Goals;histone modification;Homologous Gene;Image;Immobilization;Label;light microscopy;Malignant Neoplasms;Measurable;Measurement;Measures;Mediator;Methods;Microscope;Microscopy;Modeling;Modification;Molecular;Monitor;mRNA Precursor;mutant;Mutate;Nuclear;Nuclear Extract;Nucleosomes;Oncogenes;Pharmaceutical Preparations;Phosphotransferases;Process;promoter;Property;recruit;residence;response;RNA Polymerase II;RNA Splicing;Role;Saccharomyces cerevisiae;SAGA;Side;single molecule;Slide;Spectrum Analysis;synergism;System;Tail;Techniques;Technology;Testing;therapy design;Total Internal Reflection Fluorescent;Transcription Coactivator;transcription factor;Transcription Initiation;Transcriptional Activation;Transfer RNA;VP 16;Work;Yeasts

PROJECT_TITLE: Single-molecule analysis of eukaryotic transcription activation

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

PHR: Project Narrative Diseases caused by intracellular pathogens remain one of the largest challenges facing the international biomedical community. The proposed studies on the facultative intracellular human pathogen Listeria monocytogenes will provide insight into how pathogens recognize and respond to host inflammation. These studies are relevant to the treatment and prevention of diseases caused by intracellular pathogens.

PI_NAMEs: PORTNOY, DANIEL A (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Amino Acids;Bacteria;Biological Models;Cells;Cholesterol;Communities;Cues;Cytolysins;Data;Defect;design;Disease;disorder prevention;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Sequence Alteration;Drug Metabolic Detoxication;Environment;Event;Exposure to;Family;foodborne pathogen;Frequencies;Funding;Gene Expression Profiling;genetic approach;Genetic Screening;Glutathione;glutathione synthase;Glycolysis;Goals;Growth;Guanine;human pathogen;In Vitro;in vivo;Infection;Inflammation;insight;Interferon Activation;Interferon Type II;International;Lactoylglutathione Lyase;Listeria;Listeria monocytogenes;Listeria monocytogenes hlyA protein;Literature;Liver;Macrophage;Mediating;Modeling;monocyte;Mus;mutant;Mutation;Nucleotide Excision Repair;pathogen;Pathogenesis;Pathway interactions;Phagocytosis;Phagosomes;Phenotype;Process;Production;Pyruvaldehyde;Reaction;repaired;Research;Resistance;reverse genetics;Side;Spleen;Testing;tissue/cell culture;transcription factor;Virulence;Virulent

PROJECT_TITLE: How Listeria senses and responds to different host environments

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-D (02)]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative: This research is relevant to public health because it helps to understand the pathophysiological relevance of sterol regulator element binding proteins (SREBPs) in ocular hypertension and glaucoma, a blinding eye disease suffered by millions of people worldwide. By investigating a novel molecular mechanism involved in the regulation of aqueous humor outflow, this project will determine the relationship between SREBP activation status, lipid levels in trabecular meshwork, and the status of actin polymerization and communication of actin with extracellular matrix. Thus, intervention to activation of SREBPs can identify novel treatment paradigms for ocular hypertension and glaucoma.

PI_NAMEs: PATTABIRAMAN, PADMANABHAN PARANJI (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Acetyl-CoA Carboxylase;Actins;Anterior;Aqueous Humor;Architecture;Binding Proteins;Biochemical;Biogenesis;Biology;Biomechanics;Biophysics;Blindness;burden of illness;Cell Adhesion;Cell membrane;Cells;Cholesterol;Coenzyme A;Collagen;combat;Communication;confocal imaging;Cytoskeleton;Deposition;Drainage procedure;Elements;Enzymes;Evaluation;Event;Excision;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Eye;Eye diseases;fatty acid biosynthesis;Fibronectins;fluorescence lifetime imaging;Focal Adhesions;Genes;Genetic Transcription;Glaucoma;Goals;high intraocular pressure;Homeostasis;Human;Hyperlipidemia;In Vitro;in vivo;Incidence;Intervention;Knowledge;Link;lipid biosynthesis;lipid metabolism;Lipids;Maintenance;Mechanical Stress;Mechanics;mechanotransduction;Mediating;Membrane;Microtubules;Molecular;Mus;novel;Ocular Hypertension;optic nerve disorder;Oxidoreductase;Pathway interactions;Patients;Persons;Phospholipids;Physiologic Intraocular Pressure;Play;polymerization;Polymers;pressure;Primary Open Angle Glaucoma;Process;Property;protein activation;Public Health;Quality of life;Regulation;Regulatory Element;Research;Resistance;response;Risk;Risk Factors;Role;Signal Transduction;Signaling Protein;SRE-1 binding protein;SRE-2 binding protein;sterol homeostasis;Sterols;Stretching;synergism;Testing;Time;Tissues;Trabecular meshwork structure;transcription factor;Transcriptional Regulation;Vision;Work

PROJECT_TITLE: Transcriptional control of lipid biogenesis in trabecular meshwork and intraocular pressure regulation

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Immunization;Immunotherapy;Neurodegenerative;Neurosciences;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE The US FDA recently approved aducanumab, an antibody that promotes clearance of Aβ plaques in patients with Alzheimer's disease, and other antibodies are currently tested in patients to remove brain aggregates of Tau, another protein causing Alzheimer's disease. Here we propose to study whether Alzheimer's disease patients and mouse models develop natural antibodies and immune responses against Aβ and Tau aggregates, whether these responses correlate with disease progression and whether their presence can help identify patients that will benefit from antibody therapy.

PI_NAMEs: COLONNA, MARCO  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: abeta accumulation;Abeta clearance;Active Immunization;Active Immunotherapy;Adjuvant;Aducanumab;Affinity;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;Animal Model;Antibodies;Antibody Affinity;Antibody Response;Antibody Therapy;Antigens;Autoimmune;B-cell receptor repertoire sequencing;B-Lymphocytes;Blood;Bone Marrow;Brain;Cause of Death;CD8-Positive T-Lymphocytes;Cells;Central Nervous System;Cerebrospinal Fluid;Cervical lymph node group;Cessation of life;cisterna magna;Clinical;Clinical Trials;Clonal Expansion;CNS autoimmunity;Cognition;cranium;cytokine;Data;Defect;Disease;Disease Progression;draining lymph node;Elderly;Excision;experience;extracellular;Future;Genetic Transcription;Human;Immune;Immune response;Immunization;Immunize;Immunophenotyping;Immunotherapy;Impaired cognition;improved;Individual;Inflammation;Inflammatory;Injections;innovation;Location;Mature B-Lymphocyte;Mediating;Meningeal;Meningeal lymphatic system;Meninges;Meningoencephalitis;Methodology;Methods;migration;Modeling;Molecular;mouse model;Mucous Membrane;Mus;natural antibodies;Nerve Degeneration;Neurofibrillary Tangles;novel;Pathologic;Pathway interactions;patient stratification;Patients;Peptides;Peripheral;peripheral blood;peripheral lymphoid organ;Phase II Clinical Trials;Phenotype;Population;programs;Proteins;QS21;Reporting;Research;response;Route;Sampling;Senile Plaques;Serum;single cell analysis;Site;Sorting;Source;Specificity;Spleen;stem cell migration;stem cells;subcutaneous;symptom treatment;T cell infiltration;T cell receptor repertoire sequencing;T cell response;T-Lymphocyte;tau aggregation;tau Proteins;Tauopathies;Testing;Therapeutic;transcriptome sequencing;Vaccine Antigen;young adult

PROJECT_TITLE: Spontaneous and Induced B cell and T cell responses in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Cost Effectiveness Research;Depression;Health Services;Mental Health;Mental Illness;Prevention;Rehabilitation;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH Women diagnosed with breast cancer at or before age 50 are at increased risk for depression and other psychological and physical symptoms that may persist for years after diagnosis, with detrimental effects on quality of life, treatment adherence, and long-term health. The proposed phase III randomized clinical trial will test two new digital versions of a brief mindfulness intervention for younger breast cancer survivors in the National Cancer Institute's nationwide network of community and clinical oncology providers. Identifying effective, low cost, and scalable strategies to address depressive symptoms in younger breast cancer survivors is a high priority with substantial potential for enhancing long-term mental and physical health in this vulnerable population and reducing burden on the health care system.

PI_NAMEs: BOWER, JULIENNE E (contact);GANZ, PATRICIA A.

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Address;Adherence;Adoption;Aftercare;Age;Attention;Awareness;breast cancer diagnosis;Breast Cancer survivor;Clinical;Clinical Oncology;clinical research site;clinically relevant;Community Clinical Oncology Program;Community Networks;community setting;Control Groups;cost;Cost Analysis;cost effectiveness;cost-effectiveness evaluation;Data;demographics;depressive symptoms;design;Diagnosis;digital;digital intervention;Disease;Distress;economic evaluation;efficacy evaluation;efficacy testing;Enrollment;Ensure;experience;Fatigue;follow-up;Future;General Population;Health;Health Personnel;Healthcare Systems;Hot flushes;human old age (65+);Impairment;improved;Institution;instructor;Intervention;intervention delivery;intervention effect;Link;Long Term Survivorship;Malignant Breast Neoplasm;Malignant Neoplasms;Mediator;Meditation;Mental Depression;Mental Health;mindfulness;mindfulness intervention;mindfulness meditation;Morbidity - disease rate;National Cancer Institute;Nature;older women;Oncology;online version;Outcome;Participant;patient engagement;Patients;Peer Review;Personal Satisfaction;Persons;Phase;physical conditioning;physical symptom;pilot test;Population;post intervention;primary endpoint;primary outcome;Productivity;Program Effectiveness;programs;Protocols documentation;Provider;psychologic;psychological symptom;Public Health;Quality of life;Randomized;randomized, clinical trials;Recording of previous events;Recurrence;Reporting;Research;Risk;rumination;secondary endpoint;secondary outcome;Self Direction;self-compassion;Site;Sleep disturbances;Sleeplessness;social health determinants;Societies;Stress;Survivors;Techniques;Testing;therapy design;Time;treatment adherence;vasomotor symptoms;Vulnerable Populations;Well in self;Woman;women's diagnosis;Work;young woman

PROJECT_TITLE: Mindfulness Meditation for Younger Breast Cancer Survivors:  Testing Digital Interventions in Clinical and Community Settings


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Clinical Research;Genetics;Nutrition;Regenerative Medicine;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Increased glucose and fat metabolism are essential for tumor progression, making these pathways a potential target for cancer therapeutics. As adipose can be obtained via liposuction and is commonly implanted in plastic surgery, it can be readily used for cellular therapy. Here, we will take advantage of this property to engineer adipocytes and adipose organoids to have increased glucose and fat utilization, enabling them to out-compete tumor cells for these essential resources, and implant them both in cell culture and mouse cancer models to test their therapeutic potential.

PI_NAMEs: AHITUV, NADAV  (contact)

PROGRAM_OFFICER_NAME: BYUN, JUNG SHIN

PROJECT_TERMS: Abdomen;Adipocytes;Adipose tissue;Adjuvant;angiogenesis;Area;Biological Assay;Biological Process;Biomedical Engineering;BRCA mutations;BRCA1 Mutation;Breast;Breast Cancer Model;Breast Cancer Patient;Brown Fat;cancer cell;Cancer cell line;cancer genetics;Cancer Model;Cancer Patient;cancer predisposition;cancer subtypes;cancer therapy;cancer type;Cell Culture Techniques;Cell Line;Cell model;Cell Proliferation;Cell Therapy;Cells;chimeric antigen receptor T cells;Clinical;Coculture Techniques;Colon;Contralateral Breast;CRISPR-mediated transcriptional activation;Desire for food;drug development;Endocrine;Energy Metabolism;Engineering;Estrogen receptor positive;Excision;Fatty acid glycerol esters;Female;Gene Combinations;Genes;Genetic;Genetic Models;Genetic Models for Cancer;Glucose;glucose metabolism;glucose transport;glucose uptake;Glycolysis;Growth;Hemostatic function;Hormone secretion;Human;Hypoxia;Immunodeficient Mouse;Implant;innovation;Insulin;Intestines;lipid metabolism;Lipids;Liver;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;Measures;metabolic profile;Metastatic Neoplasm to the Lung;mouse genetics;Mouse Mammary Tumor Virus;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;novel;Operative Surgical Procedures;Organ;Organoids;Outcome;Oxygen Consumption;Pancreas;Pathway interactions;Phenotype;Plastic Surgical Procedures;polyoma middle tumor antigen;Procedures;Process;Proliferating;Property;Prostate;Recurrence;Resected;Resources;Source;Suction Lipectomy;Testing;Therapeutic;Tissues;translational potential;Transplantation;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor progression;Tumor Tissue;Up-Regulation;Work;Xenograft procedure

PROJECT_TITLE: Bioengineering adipocytes for cancer therapy

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Dementia;Hydrocephalus;Neurosciences;Rare Diseases

ORG_DEPT: NEUROSURGERY

PHR: How the brain determines cerebral ventricular volume, and how that in turn affects brain function or the development of normal pressure hydrocephalus, are poorly understood. This proposal will investigate our discovery of an ependymal chemosensory-mechanotransduction system that uses motile cilia to convert chemical signals into changes in flow which govern ependymal cell junction assembly, ventricular wall stiffness and ependymal permeability. By controlling ventricular compliance and the exchange of CSF between the ventricular and interstitial spaces, this system regulates ventricular volume, the relative distribution and composition of fluid in the ventricular and interstitial compartments, and neuronal activity in brain regions that subserve memory and motor functions.

PI_NAMEs: JOHNSON, MARK D (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: absorption;Acute;Adult;Affect;Agonist;antagonist;awake;beta catenin;Brain;brain abnormalities;Brain region;Calpain;Cells;cerebral atrophy;Cerebrospinal Fluid;cerebrospinal fluid flow;Cerebrum;Characteristics;Chemicals;Cilia;cilium motility;Dementia;dentate gyrus;Development;diagnostic biomarker;DNA Sequence;Drainage procedure;Ependymal Cell;epithelial Na+ channel;Frequencies;Functional disorder;Gait;Gene Expression;Genes;Harvest;Hippocampus;Hydrocephalus;improved;Incontinence;Infection;Intercellular Fluid;Intercellular Junctions;interstitial;Intracranial Hemorrhages;Intracranial Hypertension;Intracranial Pressure;Ligands;Liquid substance;Measures;mechanotransduction;Memory;Motility;Motor;Motor Apraxias;Mus;Mutant Strains Mice;Mutation;Neurologic Deficit;Neurons;Normal Pressure Hydrocephalus;Obstruction;overexpression;p38 Mitogen Activated Protein Kinase;Parietal Lobe;Patients;Permeability;Photometry;PI3K/AKT;Piezo 1 ion channel;planar cell polarity;pressure;Process;Production;Proteins;Proteomics;receptor;Receptor Activation;Research Personnel;response;Role;Sensory;sensory system;Serum Proteins;Shunt Device;Signal Pathway;Signal Transduction;Signaling Molecule;Sleep;social;Structure of choroid plexus;subventricular zone;System;transcriptome sequencing;Ventricular

PROJECT_TITLE: A Chemosensory-Mechanotransduction System Regulating Ventricular Size and Brain Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-W (90)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Genetics;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE The human brain is comprised of diverse, functionally relevant areas that enable complex cognition, perception, and judgment; importantly, neurodevelopmental disorders present with distinct phenotypes across cortical areas and layers. However, how these terminal cell fates emerge is still not well understood and because of this gap in our knowledge, stem cell based models of the developing human brain such as cortical organoids do not reflect the unique aspects of individual cortical areas. This proposal will survey the role of prefrontal cortex enriched transcription factors and terminal factors for laminar fate specification to evaluate the relative contributions of these signals in driving cortical arealization in order to improve understanding of how areas and layers develop and to better understand how neurodevelopmental disorders emerge.

PI_NAMEs: BHADURI, APARNA  (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Area;Atlases;Automobile Driving;Awareness;Bioinformatics;bioinformatics tool;Body System;Brain;BRAIN initiative;candidate identification;cell cortex;Cell Density;Cell Fate Control;cell fate specification;cell type;Cells;Cerebral cortex;Cognition;cognitive task;Complex;Conscious;CRISPR-mediated transcriptional activation;critical period;Data Set;Decision Making;design;Development;Disease;empowerment;Etiology;Evaluation;Event;experimental study;Foundations;Gene Expression Profile;Generations;Genes;Genetic;Genetic Transcription;Goals;Human;Human Development;improved;Individual;innovation;interest;Judgment;knock-down;Knowledge;Maintenance;Measures;Methods;Modeling;Molecular;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neurons;neuropsychiatric disorder;novel;Organoids;overexpression;Pattern;Perception;Phenotype;Prefrontal Cortex;programs;Publishing;query tools;Rodent;Role;Seminal;sensory input;sensory integration;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;stem cell model;Study models;Surveys;System;Testing;three-dimensional modeling;Time;tool;transcription factor;virtual;Work

PROJECT_TITLE: Elucidating Regulation of Cell Fate Specification in Human Cortical Development to Understand Etiology of Neurodevelopment Disorders

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Collectively, neurologic and psychiatric disorders account for over a quarter of the global burden of disease, with disproportionately high rates of illness in low-middle income countries where expert resources are scarce. In order to create the expertise necessary to develop effective treatments, prevention and mitigation strategies, and public policy, we have developed a brain health research training program in Rwanda. This program will create the regional expertise and instrumentation needed to catalyze a sustainable brain health research program in Sub-Saharan Africa.

PI_NAMEs: KOLTAI, DEBORAH C (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Africa;Area;barrier to care;Botswana;brain health;burden of illness;Central Nervous System;Congo;Country;Development;Disease;Doctor of Philosophy;Fellowship;Foundations;Future;Health Services Accessibility;Income;Instruction;instrumentation;laboratory experience;life span;Master of Science;Measures;Mental disorders;Mentors;Nervous System Disorder;Neuroanatomy;neurobehavior;neurobehavioral;Neurocognition;Neurocognitive;neuroethics;neurological rehabilitation;Neurosciences;Outcome;Policies;Postdoctoral Fellow;programs;Psychometrics;Research;Research Design;Research Personnel;responsible research conduct;Rwanda;Scientist;South Africa;statistics;Students;Training;Training Programs;Uganda;Universities;World Bank

PROJECT_TITLE: Building Brain Health Research Capacity in Rwanda: Neurocognition and Neurobehavior Across the Lifespan

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-C (50)]


NIH_SPENDING_CATS: Asthma;Lung

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Narrative  In this cycle of HL058506 we will explore a fascinating new mode of receptor regulation in which the inhibition of an intracellular molecule, the histone deacetylase HDAC11 that typically functions in regulating access to DNA, regulates the localization and activity of the 2 adrenoceptor (2AR) in airway smooth muscle. Because the 2AR is an important therapeutic target in the management of asthma, understanding the mechanisms by which HDAC11 inhibition regulates 2AR signaling and function could ultimately lead to an entirely novel way to treat obstructive lung diseases.

PI_NAMEs: PENN, RAYMOND B. (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: A kinase anchoring protein;Adipocytes;Adrenergic Receptor;Affect;Agonist;Arrestins;Asthma;asthmatic;Basic Science;beta-2 Adrenergic Receptors;Biochemical;Biological Sciences;Biology;Body System;Cell membrane;cell type;Cells;Chronic;Clinical;clinically significant;Coupled;Coupling;Data;desensitization;Development;Disease;DNA;Dose;drug development;EP4 receptor;Exhibits;fascinate;Foundations;G protein coupled receptor kinase;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Expression;Genetic;Gravin;GTP-Binding Proteins;HDAC11 gene;Histone Deacetylase;Human;imaging approach;improved;in vivo;in vivo Model;inhibitor;knock-down;Knock-out;Lung;Lysine;Mediating;member;Membrane;Membrane Microdomains;migration;Modeling;Molecular;Mus;Muscle Cells;Muscle function;mutant;myristoylation;novel;novel therapeutics;Obstructive Lung Diseases;Outcome Assessment;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Play;Post-Translational Protein Processing;Proliferating;prophylactic;pulmonary function;receptor;receptor function;Receptor Signaling;Recycling;Regulation;Research;respiratory smooth muscle;Role;Safety;Signal Transduction;small molecule inhibitor;Smooth Muscle Myocytes;System;Testing;Therapeutic Effect;therapeutic target;Time;Tissues;Translating;Treatment Efficacy

PROJECT_TITLE: G Protein-Coupled Receptor Regulation in Airway Myocytes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-H (03)]


NIH_SPENDING_CATS: Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Spinal Muscular Atrophy

PHR: Project Narrative SMN-inducing therapies have been approved for the treatment of SMA, but they do not represent a cure for the disease and significant motor deficits often persist in treated individuals. The development of add-on therapies that may enhance clinical outcome is therefore highly sought after to address the urgent, unmet needs of SMA patients. Building on recent advances and preliminary data, this project aims to address this outstanding issue through the discovery of novel disease mechanisms and therapeutic targets as well as pre-clinical testing of a new pharmacological approach suitable for use in combination with SMN-inducing drugs.

PI_NAMEs: PELLIZZONI, LIVIO  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Address;Amino Acids;Award;Behavioral;Biological Assay;blood-brain barrier permeabilization;Cessation of life;chemokine;Clinical;combinatorial;cytokine;D Aspartate;Data;Denervation;Development;Disease;Disease Pathway;Electrophysiology (science);Functional disorder;Gene Delivery;Genetic;genetic approach;Glutamate Agonist;Glutamate Receptor;Glutamates;Histones;human disease;improved;Individual;Infant Mortality;Inflammation;Inherited;Innate Immune Response;insight;Interdisciplinary Study;Intervention;Knock-out;Link;Logic;Mediating;Mediator;Messenger RNA;Microglia;Modeling;Molecular;Morphology;Motor;motor deficit;motor disorder;motor function improvement;Motor Neurons;mouse model;mRNA Precursor;Mus;Mutation;Natural Immunity;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neuromuscular Junction;neuron loss;Neuronal Dysfunction;Neurons;neurotransmission;new therapeutic target;novel;Outcome;Pathogenicity;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Preclinical Testing;prevent;Property;Proprioceptor;protein function;Publishing;Research Project Grants;restoration;RNA;RNA Processing;RNA Splicing;Role;Safety;Sensory;sensory mechanism;Severities;Severity of illness;skeletal muscle wasting;Small Nuclear Ribonucleoproteins;SMN deficiency;SMN protein (spinal muscular atrophy);SMN1 gene;Spinal Cord;Spinal Muscular Atrophy;Stimulator of Interferon Genes;Supplementation;Symptoms;Synapses;System;Testing;Therapeutic;therapeutic candidate;therapeutic target;Time;transcriptome sequencing;treatment response

PROJECT_TITLE: RNA-Mediated Mechanisms of Motor System Dysfunction in Spinal Muscular Atrophy

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Pediatric;Primary Health Care;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Language-rich interactions with a parent or caregiver can serve as a protective factor for young children, by supporting their language development and other positive long-term outcomes, but existing interventions have not had the necessary reach to families who need this information the most. This study utilizes the primary care setting as a low cost, scalable way to deliver language promotion intervention. Specifically, we will test the effectiveness and explore implementation of language promotion intervention (Talk With Me Baby) that embeds within anticipatory guidance during pediatric well-child care to boost early language development and reduce long-term disparities in health, academic, and economic outcomes.

PI_NAMEs: SALLEY, BRENDA JEANETTE (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: acceptability and feasibility;Adopted;Affect;Age;Age Months;Behavior;Caregivers;Caring;Characteristics;Child;Child Care;Child Development;Child Language;Childhood;Clinic;Clinical;cluster trial;Communities;comparison control;Consolidated Framework for Implementation Research;Control Groups;cost;Data;Development;Disparity;disparity reduction;dosage;early childhood;economic outcome;Economics;Education;effectiveness measure;effectiveness testing;effectiveness/implementation trial;efficacy trial;empowerment;Enrollment;Ensure;Environment;evidence base;Family;Frequencies;Future;group intervention;Health;health disparity;Health Personnel;Home;hybrid type 1 trial;implementation trial;improved;Income;Infant;innovation;Intention;Intervention;intervention effect;Interview;Knowledge;Language;Language Development;language outcome;literacy;Literacy Programs;Measures;Mediating;Mediator;Medical Care Team;member;Methods;neurodevelopment;novel;Outcome;Parent-Child Relations;Parenting Education;Parents;pedometer;physical conditioning;Play;Population;Primary Care;primary care clinic;primary care clinician;primary care setting;protective factors;Provider;Randomized;Readiness;Reading;Reporting;Research;Resources;Role;Schools;Site;social;sociodemographics;Spanish/English;Standardization;Structure;Surveys;Toddler;tool;Training;treatment as usual;treatment effect;Treatment Efficacy;universal prevention;verbal;Video Recording;Visit;Vocabulary;vocalization;Work

PROJECT_TITLE: Talk With Me Baby: Leveraging Well-Child Care to Enhance the Early Home Language Environment

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Cystic Fibrosis;Diabetes;Digestive Diseases;Genetics;Lung;Rare Diseases

ORG_CITY: EDMONTON

ORG_NAME: UNIVERSITY OF ALBERTA

ORG_STATE: AB

ORG_ZIPCODE: T6G 2E1

PHR: PUBLIC HEALTH RELEVANCE STATEMENT  Cystic Fibrosis (CF) is an autosomal recessive disease resulting in multi-organ disease and decreased lifespan (~45y). Diabetes (CFRD) affects 40-50% of adults with CF and is associated with worse disease outcomes and increased mortality. Impaired insulin release is the key defect underlying CFRD but the mechanisms underlying this dysfunction are poorly understood.

PI_NAMEs: HULL-MEICHLE, REBECCA LUCY (contact)

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: 3-Dimensional;Acinar Cell;Acinus organ component;Adolescent;Adult;Affect;Alpha Cell;animal data;Animal Model;Autopsy;autosome;Beta Cell;Blood capillaries;candidate identification;Cell Physiology;Cell Survival;cell type;Cells;Cessation of life;Coculture Techniques;Collaborations;comorbidity;Cystic Fibrosis;cystic fibrosis patients;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Data Set;Defect;Diabetes Mellitus;Disease;Disease Outcome;Ductal Epithelial Cell;Endothelial Cells;Etiology;experimental study;exposed human population;Exposure to;extracellular vesicles;Failure;Fibrocystic Disease of Pancreas;Functional disorder;Genetic Diseases;Glucagon;Glucose;Health;Human;Impairment;improved;In Vitro;in vivo;Inflammation;innovation;Insulin;Insulin deficiency;Intervention;Intervention Studies;islet;Islet Cell;knock-down;Knowledge;Life Expectancy;life span;loss of function mutation;Lung Diseases;Macrophage;Measurement;Mediating;Messenger RNA;Modeling;Morphology;mortality;Mutate;Mutation;novel;Organ;Outcome Measure;Pancreas;Pancreatic duct;Pathogenesis;Pathology;Pathway interactions;Pluripotent Stem Cells;premature;preservation;Proteins;Proteomics;public health relevance;Pulmonary Cystic Fibrosis;recessive genetic trait;reconstitution;response;Sampling;Site;Slice;Source;System;Testing;Time;Toxic effect;transcriptome;transcriptomics

PROJECT_TITLE: Mechanisms of Islet Failure in CF


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Substance Misuse

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative Alcohol is the leading cause of preventable birth defects. Along with ethanol dosage and timing, there are genetic underpinnings to alcohol-induced birth defects. Despite this fact, much remains to be learned about the genetic predispositions to ethanol-induced birth defects. Our studies will provide important insights into the mechanisms of gene-alcohol interactions. Due to the high conservation of gene function between zebrafish and human, the results we obtain will translate to human disease: providing candidate loci for association studies, risk factors for genetic counseling and potential therapies.

PI_NAMEs: EBERHART, JOHANN K (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: alcohol effect;alcohol exposure;alcohol sensitivity;Alcohols;Antioxidants;Apoptosis;Attenuated;attenuation;Automobile Driving;Bioinformatics;Biological Assay;Birth;Brain;Cells;Complex;Congenital Abnormality;Data;Defect;desensitization;Development;dosage;Dose;Embryo;embryonic alcohol exposure;Epigenetic Process;Ethanol;Etiology;Fertility;Fertilization;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;FRAP1 gene;gene conservation;gene function;gene product;gene regulatory network;Genes;Genetic;Genetic Counseling;Genetic Predisposition to Disease;genetic risk factor;Genetic Screening;genomic locus;high throughput analysis;Human;human disease;improved;insight;Knowledge;Lead;Learning;Mammals;Mental Retardation;Modeling;mutant;Mutation;Nature;Nervous System;neural;neurodevelopment;Neuronal Differentiation;Neurons;novel;Optics;Outcome;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Phenotype;Phosphatidylinositols;Phosphotransferases;Population;precursor cell;Prevalence;Reactive Oxygen Species;Reader;resilience;resilience factor;Resolution;Resources;Risk;Risk Factors;Signal Transduction;Spatial Distribution;Susceptibility Gene;teratogenesis;Teratogens;Testing;transcriptome sequencing;transcriptomic profiling;Transgenic Organisms;Translating;Variant;Work;Zebrafish

PROJECT_TITLE: Genetic screens in zebrafish to identify gene-ethanol interactions

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]