ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Pediatric;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Narrative There is continued concern about the negative impact of environmental exposures on human health and a shortage of qualified young scientists entering the field of environmental health sciences (EHS) who seek to elucidate the environmental causes of injuries and illnesses. Recruiting talented, energetic undergraduates to the field of environmental health sciences and encouraging them to seek advanced degrees in EHS or related fields is critical to advancing public health as it pertains to protecting the public from the negative impact of environmental exposures.

PI_NAMEs: HARRIS ADAMSON, CARISA  (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Access to Information;Address;Admission activity;Advisory Committees;Area;Back;California;career;Career Choice;Collaborations;college;Complement;Computer Models;Country;Data Analyses;Data Collection;disadvantaged student;Discipline;Disparity population;Education;Educational workshop;Enrollment;Environment;Environmental Exposure;Environmental Health;Environmental Impact;Evaluation;experience;Face;Faculty;faculty mentor;Feedback;field trip;Fostering;Future;Goals;Graduate Degree;graduate student;Grant;Health;Health Sciences;high school;High School Faculty;High School Student;Human;human subject protection;improved;Injury;Institution;Instruction;interest;Internships;laboratory experiment;Learning;member;Mentors;Minor;Minority Groups;Minority Recruitment;minority student;Monitor;Nature;NIH Program Announcements;Occupational Health;Performance;Population Heterogeneity;Postdoctoral Fellow;Process;professional atmosphere;programs;Public Health;Public Health Schools;Qualifying;recruit;Research;Research Activity;Research Design;research faculty;Research Project Grants;research to practice;Research Training;Review Literature;San Francisco;Science;Scientist;self esteem;Series;Services;social;Source;Specific qualifier value;Structure;Student recruitment;Students;success;summer internship;summer research;symposium;System;Talents;teacher;Time;Training;Training and Education;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;Underserved Population;Universities;university student;verbal;virtual;Work;Writing

PROJECT_TITLE: STEER Summer Internship Program


ADMINISTERING_IC: ES

ARRA_FUNDED: N

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Data Science;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: A better understanding of what causes autism and other neurodevelopmental disabilities can lead to better treatment and ultimately prevention of onset or disabilities. Although we know genes and prenatal and early life environments play a role, we do not yet understand the specific factors and need rigorous studies that follow pregnancies and early childhood factors as they occur, prior to symptom onset. The EARLI study is designed in this way, with many types of data about environments, medical conditions, early child development, and biological samples like blood, urine, hair, semen and placenta that can contribute to the child environmental health research community.

PI_NAMEs: VOLK, HEATHER E (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Address;Affect;Aliquot;autism spectrum disorder;autistic children;Big Data;Biological;Biological Assay;Biological Specimen Banks;Blood;California;Child;Child Development;Child Health;Code;cohort;Collaborations;Collection;Communities;comorbidity;cost;cost effective;Data;Data Collection;data harmonization;data management;Data Science;data sharing;Databases;deciduous tooth;design;Development;disability;disorder prevention;early childhood;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Health;Environmental Risk Factor;Etiology;Event;Family member;Frequencies;General Population;Genes;Goals;Hair;Heavy Metals;Home environment;Information Systems;Infrastructure;innovation;Investigation;Life;Life Cycle Stages;Maintenance;Measurement;Measures;Medical;Medical Records;method development;Methods;migration;modifiable risk;Molecular;Molecular Epidemiology;Neurodevelopmental Disability;Neurodevelopmental Disorder;novel;Outcome;Pathway interactions;Pattern;Phenotype;phenotypic data;Placenta;Population Study;Pregnancy;Pregnant Women;prenatal;prenatal exposure;Prevalence;Prevention;Primary Prevention;prospective;Prospective Studies;Protocols documentation;recruit;Recurrence;Reproducibility;Research;Research Design;Resources;Retrieval;Risk;Risk Factors;Sample Size;Sampling;School-Age Population;Secondary Prevention;Seminal fluid;Siblings;social communication;Social Interaction;Subgroup;Surveys;Symptoms;Time;Tissues;Tooth structure;Toxicant exposure;trait;Umbilical Cord Blood;Universities;Urine;Visit

PROJECT_TITLE: Expanding the Value of the EARLI study: Small Cohort with Big Data


ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Narrative Decades of investigations have established chronic dietary exposures to fungal toxins (aflatoxins) and chronic inflammation from hepatitis B viral infection as known risk factors for developing liver cancer. We have recently discovered an additional risk factor - deficiencies in a DNA base excision repair gene. Since at-risk portions of the human population carry deleterious mutations in this repair gene, this application will investigate deficiencies in this pathway as a driver of liver carcinogenesis using biochemical, cell, and murine models.

PI_NAMEs: LLOYD, R. STEPHEN (contact)

PROGRAM_OFFICER_NAME: HEACOCK, MICHELLE

PROJECT_TERMS: adduct;Affect;Aflatoxin B1;aflatoxin B1-DNA adduct;Aflatoxins;Africa South of the Sahara;Americas;Automobile Driving;base;Base Excision Repairs;Binding;Biochemical;biochemical model;Biochemical Pathway;Biological;Cancer Etiology;carcinogenesis;Cell Line;Cell model;Cells;Central America;Cessation of life;China;Chronic;cohort;County;CRISPR/Cas technology;Data;Databases;Death Rate;design;Development;diagnostic tool;dietary;Disease;Disease susceptibility;DNA;DNA Adducts;DNA Binding;DNA Damage;DNA glycosylase;DNA Repair;DNA Repair Disorder;DNA Repair Pathway;DNA Sequence;DNA sequencing;Dose;early onset;effective therapy;Engineering;Environmental Health;Environmental Risk Factor;Enzymes;epidemiology study;Epoxy Compounds;Etiology;European;Excision;exome sequencing;Exposure to;Fapy-dG;Far East;Frequencies;fungus;gene repair;Genetic Predisposition to Disease;genetic risk factor;genetic variant;Genetic Variation;Genomic Instability;genotoxicity;Genotype;Geographic Distribution;Geography;global environment;global health;Goals;Grain;Guanine;HBV and Aflatoxin;Health;Hepatitis B;Hepatitis B Incidence;Hepatitis B Surface Antigens;Hepatocarcinogenesis;Human;Incidence;Individual;Inflammation;Ingestion;Investigation;Knock-out;Knowledge;Laboratories;Liver;Liver Microsomes;Liver neoplasms;Malignant neoplasm of liver;Malignant Neoplasms;Molecular;Molecular Epidemiology;mouse model;Mus;Mutagenesis;Mutation;Mycotoxins;Nucleotide Excision Repair;Nuts;Oncogenic;Onset of illness;Pathway interactions;Persons;Phenotype;Population;population based;Populations at Risk;Positioning Attribute;Predisposition;Primary carcinoma of the liver cells;Process;Property;Proteins;Reaction;repair enzyme;repaired;Reporting;response;Risk;Risk Factors;Role;Site;South America;stressor;Surface Antigens;Testing;Tissues;Transgenic Mice;Translating;tumor;tumor DNA;Variant;Viral;virtual;Virus Diseases

PROJECT_TITLE: Role of Base Excision Repair in Limiting Hepatocellular Carcinomas

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cancer;Skin Cancer

ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Invasive melanoma is a potentially deadly medical condition, with an incidence of 100,000 new cases in 2021 alone. Melanoma research has mainly focused on melanocyte dysregulation to understand the disease; yet, the epidermis is an important microenvironment for healthy melanocytes, which adhere to and communicate with keratinocytes to maintain homeostasis. In this project, we will test hypothesis that melanocytes and epidermal cells form specialized adhesions important for melanocyte migration and retention within the epidermis, thereby contributing to the suppression of melanoma metastasis.

PI_NAMEs: RICHARDS, DENAY  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Acceleration;Actins;Adherens Junction;Adhesions;Adhesives;assault;Basement membrane;Basic Science;Behavior;Belief;Biological;Cadherins;cell motility;cell type;Cells;Cellular biology;cellular imaging;Cessation of life;Clinical;Collaborations;Color;Communication;Complex;confocal imaging;Cre lox recombination system;Data;Defect;design;Development;Diagnosis;Disease;E-Cadherin;Embryo;Environment;Epidermis;Epithelial Cells;Epithelium;Esthetics;Excision;Fibroblasts;Future;Genetic;Genetic Transcription;Goals;Hair follicle structure;holistic approach;Homeostasis;Hospital Departments;Human;Image;Immune;Immunoglobulin Class Switching;Impairment;Incidence;Individual;intercellular communication;Intercellular Junctions;Intervention;Invaded;Keloid;keratinocyte;Knock-out;Knowledge;Label;Life;Mechanics;Medical;melanoblast;melanocyte;Melanoma;Melanoma Cell;Membrane;Mentorship;Metastatic Melanoma;migration;Molecular;Morphology;mortality;mouse model;Mus;N-Cadherin;Neoplasm Metastasis;novel strategies;Operative Surgical Procedures;Patients;Pigments;Plastic Surgeon;Plastic Surgical Procedures;Precancerous Melanosis;prevent;Proliferating;promoter;reconstruction;Recording of previous events;Reporter;Research;Resolution;Resources;Role;single-cell RNA sequencing;Skin;skin barrier;Skin Cancer;superresolution imaging;superresolution microscopy;Surgeon;Survival Rate;Testing;Therapeutic Research;Training;transcriptomics;Translational Research;tumor;Tumor Suppression;ultra high resolution;United States;Universities;University Hospitals;Up-Regulation;Visualization;Vitiligo;Wood material;Work

PROJECT_TITLE: Investigating the epidermal microenvironment in melanoblast migration and invasion: a novel approach to understanding invasive melanoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: AMES

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Project Narrative: Understanding ovarian cellular signaling changes that are induced by obesity is critical to improve female fertility and to minimize risk from alkylating chemical exposures. These tools are critical for maintenance and improvement of reproductive health in girls and women.

PI_NAMEs: KEATING, AILEEN FRANCES (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Address;Adult;Affect;AHR gene;Alkylating Agents;Amenorrhea;Anthracenes;Antioxidants;Area;Aromatic Polycyclic Hydrocarbons;ataxia telangiectasia mutated protein;ATM activation;Birth Rate;carcinogenesis;Chemical Exposure;Chemicals;ChIP-seq;Chronic;Complication;Conceptions;Congenital Abnormality;Coronary heart disease;Couples;Data;Development;Diet;dimethylbenzanthracene;DNA Adducts;DNA Damage;DNA Repair;DNA Repair Gene;Environment;environmental chemical exposure;Enzymes;Estrus;experience;Exposure to;Fatty acid glycerol esters;feeding;Female;female fertility;Fertility;Foundations;Functional disorder;Generations;girls;Goals;Health;histone modification;Hyperphagia;implantation;improved;in utero;Infertility;innovation;interest;Investigation;Learning;Life;Light;Maintenance;Malignant neoplasm of ovary;Mental Depression;Metabolic;Metabolic Biotransformation;Metabolism;Methylation;Minority Groups;Minority Women;Mission;Modeling;Mus;National Institute of Environmental Health Sciences;Neonatal;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;Obesity;offspring;oocyte quality;Osteoporosis;Outcome;Ovarian;ovarian damage;Ovarian Follicle;Ovary;ovotoxicant;ovotoxicity;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Periodicity;Phenotype;Physiological;PIK3CG gene;Postmenopause;Pregnancy;Premature Menopause;prepuberty;promoter;protein metabolism;Proteins;Puberty;Public Health;Publishing;Reactive Oxygen Species;repaired;reproductive;Reproductive Health;reproductive success;Research;response;Risk;risk minimization;Role;Signal Transduction;Societies;socioeconomics;Solid;Specific qualifier value;Spontaneous abortion;Subfecundity;sugar;Thinness;tool;transcriptome sequencing;Woman;Women's Health;women's reproductive health;Work

PROJECT_TITLE: Investigating obesity-induced altered ovarian intracellular signaling

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: GAINESVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: FL

PHR: With advancing age there is a higher incidence of mobility related falls, leading to devastating consequences. One component of mobility often overlooked but commonly performed is turning, which can lead to injury when performed poorly. As such, there is a need for effective rehabilitation interventions to improve turning function for older adults. Transcranial direct current stimulation (tDCS) is a promising and clinically-feasible approach that might enhance the effects of rehabilitation. tDCS is a non-invasive form of electrical stimulation delivered to the brain via electrodes placed on the scalp. When active tDCS is delivered during walking and turning rehabilitation sessions, it might help to strengthen neural circuits and promote better outcomes as opposed to sham tDCS. The goal of this study is to assess whether combining active tDCS with practice of challenging walking tasks, including turning, improves turning performance in older adults. This outcome would provide supporting data to pursue a larger clinical trial assessing the use of tDCS for rehabilitation specific to turning.

PI_NAMEs: SWANSON, CLAYTON  (contact)

PROJECT_TERMS: Accounting;Address;Adjuvant;Adult;aged;Aging;Anodes;Appointment;Area;Award;Behavior assessment;Bilateral;Brain;career;career development;Cathodes;Characteristics;Clinical;Clinical Trials;cognitive function;cognitive testing;Complex;Corticospinal Tracts;Data;design;Elderly;Electric Stimulation;Electrodes;Enrollment;Equilibrium;experience;Faculty;fall risk;falls;Florida;Future;Gait;Goals;Grant;gray matter;Hip Fractures;human old age (65+);Impairment;improved;Incidence;Individual Differences;Infrastructure;Injury;innovation;interest;Intervention;Knowledge;Learning;Left;Lower Extremity;Magnetic Resonance Imaging;Measures;Medical center;Mentors;Mobility decline;mobility rehabilitation;motor learning;Motor Skills;Movement;MRI Scans;neural;neural circuit;Neuroanatomy;neuroimaging;Neurologic;neuromechanism;neurophysiology;neuroregulation;noninvasive brain stimulation;novel;older adult;Outcome;Outcome Measure;Parents;Participant;Performance;Persons;Pilot Projects;Play;post intervention;post stroke;Prefrontal Cortex;primary outcome;Protocols documentation;Quality of life;Randomized;Rehabilitation therapy;Research;Rest;restoration;Risk;Role;Sampling;Scalp structure;sensor;Short-Term Memory;skills;Stroke;stroke hemiparesis;stroke survivor;Structure;Task Performances;Testing;Time;Training;transcranial direct current stimulation;Transcranial magnetic stimulation;Universities;Veterans;Walking;walking intervention;walking speed;wireless

PROJECT_TITLE: Brain Networks of Turning Performance with Aging and Stroke

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Immunotherapy;Lupus

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Double-negative T cells are a rare population of T cells that lack CD4 and CD8 expression and abnormally expand in lupus patients. While current studies demonstrate that DN T cells play an important pathogenic role in autoimmune disease development, the mechanisms that regulate DN T cell homeostasis are completely unknown and there are no therapies to selectively deplete DN T cells in vivo. In this proposal, we will define the cellular and molecular mechanisms that control DN T cell development and function, and we will develop a novel mechanism-based immunotherapy to deplete DN T cells.

PI_NAMEs: RANDALL, TROY D (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Adoptive Transfer;Apoptosis;Autoantibodies;Autoimmune;Autoimmune Diseases;autoimmune lymphoproliferative syndrome;autoreactive B cell;autoreactivity;B-Lymphocytes;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Child;cytokine;Data;design;Development;Disease;Dose;Equilibrium;experimental study;Frequencies;Generations;Genetic Diseases;Genetic Transcription;Goals;Helper-Inducer T-Lymphocyte;Heterogeneity;Homeostasis;Human;Hybrids;IL17 gene;Immunosuppression;Immunotherapy;in vivo;inhibitor;Interleukin-2;Lupus;lupus prone mice;Mediating;Molecular;Mus;novel;novel therapeutic intervention;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Phenotype;Plasma Cells;Plasma Enhancement;Play;Population;prevent;Production;programs;response;Role;self help;Severity of illness;Signal Transduction;single-cell RNA sequencing;STAT3 gene;synergism;Systemic Lupus Erythematosus;T cell response;T-Cell Development;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention

PROJECT_TITLE: Origin and Function of Double Negative T cells in Lupus

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Academic researchers, community-based organizations, health care providers, and state and local government officials will work together to implement recommendations from a scientifically-grounded, community-informed Public Health Action Plan to reduce air pollution and its adverse health effects, and strengthen and support sustained, equitable and effective community engagement in translation of research to action to promote environmental public health. Poor environmental quality and associated health impacts are social and environmental justice issues in Michigan and elsewhere. This project aims to enhance health and environmental equity.

PI_NAMEs: BATTERMAN, STUART A;SCHULZ, AMY J (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Address;Advocacy;Advocate;Air;air filtration;Air Pollutants;Air Pollution;Area;Businesses;Carbon;Carbon Black;Child;Child Health;coarse particles;Collaborations;Communities;Community Actions;community based participatory research;community engagement;community organizations;Data;Data Analyses;data portal;Development;Disease;Education and Outreach;Effectiveness;Environment;Environmental Exposure;Environmental Health;environmental justice;Equity;Evaluation;experience;Filtration;fine particles;Foundations;Goals;Government Officials;Grant;Health;Health Benefit;health literacy;Health Personnel;Impact evaluation;improved;Indoor environment;Industrialization;Industry;Inequity;Intervention;Knowledge;Leadership;Link;Local Government;Measures;member;meteorological data;Michigan;Monitor;Outcome;Ozone;Parents;Particulate Matter;pollutant;Poverty;Process;process evaluation;programs;Public Health;Recommendation;Recording of previous events;Records;Research;Research Personnel;Resources;Risk;Schools;Science;segregation;Site;skills;Social Justice;Source;State Government;summer program;Training;Translating;Translational Research;Translations;usability;ventilation;vulnerable community;Work;Youth

PROJECT_TITLE: Community Action to Promote Healthy Environments


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: RIVERSIDE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: Project Narrative This project contributes to fundamental understanding of reductive dehalogenation at a synergistic materials- microbe interface, which addresses challenges in bioremediation of halogenated compounds and co- contaminants that are toxic to public health. In the long term, successful demonstration of this project can lead to novel remediation technologies, thus significantly reducing public exposure of those harmful contaminants.

PI_NAMEs: LIU, CHONG ;MEN, YUJIE  (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TITLE: Synergistic Material-Microbe Interface towards Faster, Deeper, and Air-tolerant Reductive Dehalogenation


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Machine Learning and Artificial Intelligence;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

PHR: This study will provide new and much needed information on the magnitude, sources, and impacts of exposure to commonly encountered chemicals, both individually and in combination, among pregnant women, and innovative methods for identifying relevant biological pathways and assessing health impacts from exposure to mixtures. These findings will have a significant impact on public health given widespread exposure to the target chemicals in the population, the growing need to identify environmental agents that adversely impact pregnancy, and the need to discover contributors to the high rates of preterm birth in the U.S. and beyond that could be prevented. Our study will also provide new information on the role of oxidative stress in adverse pregnancy outcomes which may inform future therapeutic or preventative interventions, and contribute new statistical and machine learning methods for investigating mixtures, mediation, and birth outcomes.

PI_NAMEs: MEEKER, JOHN D. (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: 37 weeks gestation;adverse pregnancy outcome;Arachidonic Acids;Aromatic Polycyclic Hydrocarbons;Behavioral;Biological;Biological Markers;Birth;Boston;Chemical Exposure;Chemicals;Childhood;Cohort Studies;Consensus;Cytochrome P450;Data;economic cost;Eicosanoids;environmental agent;environmental chemical;environmental chemical exposure;Environmental Exposure;Environmental Impact;Exposure to;Fetal Growth;Fetal Growth Retardation;Future;Geography;Goals;Health;health assessment;high dimensionality;human data;improved;Individual;Infant Mortality;innovation;insight;Intervention;Isoprostanes;Joints;Knowledge;Life;Link;Lipoxygenase;Live Birth;Low Birth Weight Infant;machine learning method;Measurement;Measures;Mediating;Mediation;Mediator;Metals;Methods;Modernization;Morbidity - disease rate;Outcome;Outcome Study;oxidation;Oxidative Stress;Oxidative Stress Pathway;Pathway interactions;Phase;phthalates;Policies;Population;Pregnancy;Pregnancy Outcome;Pregnant Women;Premature Birth;Prevalence;prevent;preventive intervention;Prostaglandin-Endoperoxide Synthase;Public Health;remediation;reproductive;Risk;Risk Factors;Risk Reduction;Role;Sampling;Societies;software development;Source;specific biomarkers;statistical and machine learning;Statistical Methods;Techniques;Testing;Therapeutic Intervention;Time;toxicant;Toxicant exposure;Tyrosine;Ultrasonography;ultrasound;Work

PROJECT_TITLE: Applying and advancing modern approaches for studying the joint impacts of environmental chemicals on pregnancy outcomes

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The ongoing theme of this program is to study the virus-cell interactions that affect HSV gene expression. Detailed knowledge of how HSV genes are transcribed, and the virus-cell interactions that contribute to their regulated expression, may allow for strategies to block activated transcription and hence virus multiplication.

PI_NAMEs: DELUCA, NEAL A. (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Affect;Binding;Binding Sites;cell type;Cells;Chromatin;Communication;Complex;density;Dissociation;Distal;DNA;DNA biosynthesis;DNA Polymerase II;DNA Viruses;DNA-Binding Proteins;Early Promoters;Epigenetic Process;Event;experimental study;Funding;Gene Expression;gene repression;Genes;genetic regulatory protein;Genetic Transcription;Genome;genomic tools;Head;Infection;insight;Knowledge;Late Promoters;Life Cycle Stages;Mediator;Modeling;Nucleoproteins;Nucleosomes;Outcome;Phosphotransferases;Play;Population;Poxviridae;Process;Productivity;programs;promoter;protein distribution;protein protein interaction;Proteins;Proteomics;Publishing;recruit;RNA;Role;Simplexvirus;Site;Structure;Tail;Testing;tool;transcription factor;Transcription Repressor;Transcriptional Activation;Viral;viral DNA;Viral Genes;Viral Genome;Viral Proteins;Viral Regulatory Proteins;Virus;Virus Diseases;virus genetics;Virus Replication;Virus-Cell Membrane Interaction

PROJECT_TITLE: Virus-cell interactions affecting HSV gene expression


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Climate-Related Exposures and Conditions;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Nutrition;Rare Diseases

ORG_CITY: PULLMAN

ORG_DEPT: ZOOLOGY

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Exposure to microcystin toxins produced by freshwater algae is associated with liver cancer. Nonalcoholic fatty liver disease is a common chronic disease that can progress to cirrhosis and liver cancer after exposure to environmental compounds. This research will determine the role of microcystin in driving progression of nonalcoholic fatty liver disease to cirrhosis and liver cancer.

PI_NAMEs: CLARKE, JOHN DANIEL (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Age;Alcohols;Algae;Animals;Attenuated;Automobile Driving;Award;Big Data;biological research;carcinogenesis;carcinogenicity;Career Mobility;cell determination;Cell Nucleus;cell type;Cells;Certification;Cholesterol;Chronic Disease;chronic liver disease;Cirrhosis;Coculture Techniques;Country;Cyanobacterium;cyanoginosin LR;Cyanotoxin;Data;defined contribution;Development;Diet;dietary constituent;dietary control;Diethylnitrosamine;Differentiation Antigens;Dissection;DNA Methylation;Dose;druggable target;Environmental Health;Euthanasia;Exposure to;Fatty acid glycerol esters;Fibrosis;Fresh Water;Genes;Hepatocyte;Histopathology;Human;In Vitro;in vivo;Individual;inhibitor;Injections;innovation;Intake;Liver;Liver diseases;Long-Term Effects;Malignant neoplasm of liver;Measures;Mediating;microcystin;Microfluidics;Modeling;National Institute of Environmental Health Sciences;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Pathogenicity;Pathologist;Pathology;Pathway interactions;Persons;Phenotype;phosphoproteomics;Phosphoric Monoester Hydrolases;Predisposition;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Protein phosphatase;Proteomics;Proto-Oncogene Proteins c-akt;Rattus;Research;Role;Science;Scientist;single nucleus RNA-sequencing;spheroids;Sprague-Dawley Rats;stellate cell;stem cell biomarkers;Strategic Planning;Testing;Toxin;transcriptomics;treatment group;tumor initiators;Unhealthy Diet;uptake

PROJECT_TITLE: Mechanisms of microcystin-induced hepatocellular carcinoma in nonalcoholic steatohepatitis


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

PHR: The proposed research is relevant to public health, because a sustainable technology will be developed for the passive bioremediation of complex mixtures of groundwater contaminants, including chlorinated solvents and 1,4-dioxane via aerobic cometabolism. The co-encapsulation of pure cultures of bacteria along with slow release compounds in hydrogels beads has the potential to lower costs and achieve high treatment efficiencies. The beads can be used to treat a broad range of contaminants and in many different platforms, including permeable reactive barriers.

PI_NAMEs: HYMAN, MICHAEL R.;ROCHEFORT, WILLIE ERNEST;SEMPRINI, LEWIS  (contact)

PROJECT_TERMS: 3-Dimensional;Aerobic;alcohol effect;Alcohols;Alkanes;anthropogenesis;Bacteria;Bioremediations;Carcinogens;Catabolism;Cells;Centers for Disease Control and Prevention (U.S.);Chloroform;Complex;Complex Mixtures;cost;Crosslinker;Development;Dichloroethylenes;Diffuse;Dimethylnitrosamine;Dioxanes;drinking water;Encapsulated;Enzymes;Ethylene Dichlorides;Ethylenes;Experimental Designs;experimental study;Formulation;gellan;Generations;Genome;Goals;ground water;Growth;Human;Hydrocarbons;Hydrogels;In Situ;interest;Label;Laboratories;large scale production;Life Cycle Stages;materials science;Measurement;Mechanics;Methods;Methylene Chloride;microbial;microorganism;Mixed Function Oxygenases;Modeling;N-nitrosodimethylamine;Output;Permeability;Physiological;Polymers;Process;Proteome;Proteomics;Public Health;Pump;remediation;Research;Rhodococcus;Sampling;scale up;screening;Site;Soil;Solvents;Starvation;Statistical Models;System;Techniques;Technology;Temperature;Test Result;Testing;Tetrachloroethylene;Toxic effect;Trichloroethanes;Trichloroethylene;United States;Validation;Vinyl Chloride;volatile organic compound;Water Supply;Work

PROJECT_TITLE: Development of Passive and Sustainable Cometabolic Systems to Treat Complex Contaminant Mixtures by Encapsulating Microbial Cultures and Slow Release Substrates in Hydrogels


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Antifungal drug resistant Candida species are a serious antimicrobial threat worldwide. The goal of this project is to determine the rate and dynamics in which drug resistant mutations are acquired in controlled evolution experiments and elucidate novel mechanisms of acquired resistance both in vitro and in vivo. Our approaches include experimental evolution, flow cytometry, mathematical modeling, comparative genomics, and molecular engineering.

PI_NAMEs: SELMECKI, ANNA M. (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: acquired drug resistance;Aneuploidy;anti-fungal agents;antimicrobial;arm;Automobile Driving;Azole resistance;Azoles;Bioinformatics;Candida;Candida albicans;Candida albicans resistance;Candida auris;Candida glabrata;Cells;Chromosome Arm;chromosome number abnormality;Chromosomes;Clinical;comparative genomics;Cryptococcus neoformans;Death Rate;Development;digital;DNA Repair Gene;DNA Sequence;Drug Exposure;Drug resistance;Elements;Engineering;Event;Evolution;Exhibits;experience;Experimental Models;experimental study;Exposure to;Failure;fitness;Flow Cytometry;Fluconazole;Fluconazole resistance;Frequencies;Fungal Drug Resistance;Future;Gene Amplification;Generations;Genes;genetic approach;Genetic Recombination;Genome;genome sequencing;Genomics;Goals;Hospitals;Human;In Vitro;in vivo;Infection;interdisciplinary approach;Inverted Repeat Sequences;Investigation;Isochromosomes;Karyotype;Left;mathematical model;Measures;Molecular;Molecular Genetics;Morbidity - disease rate;mortality;mouse model;Multi-Drug Resistance;Mutation;neglect;novel;novel strategies;novel therapeutic intervention;Outcome;Outcome Study;pathogenic fungus;Pharmaceutical Preparations;Pharmacotherapy;Point Mutation;Population;Positioning Attribute;Predisposition;Recurrence;Repetitive Sequence;Reporter;Reproducibility;Research;Research Project Grants;Resistance;resistance gene;resistance mechanism;resistance mutation;Resistant candida;Sepsis;Stress;Structure;System;TAC1 gene;Techniques;Testing;theories;Therapeutic;Time;whole genome;Work;yeast genetics

PROJECT_TITLE: Aneuploidy and Acquired Antifungal Drug Resistance in Candida species

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


PHR: Project Narrative Atherosclerotic vascular disease remains the leading cause of death in the United States with the majority of mortality due to coronary artery disease and myocardial infarction. Likewise, the Veteran population is not immune to this where a significant portion of VA medical care is focused on ischemic heart disease and its complications. Macrophages are primary cells that specialize in removing the excess lipids and other debris present in the atherosclerotic plaque. We have found that macrophages have the ability to augment their degradation machinery and when this response is stimulated genetically in mice, they have reduced atherosclerosis. Furthermore, we have discovered a key regulatory pathway in macrophages that can stimulate this degradation machinery. We propose to dissect the mechanisms involved in this regulation both in vitro and in vivo with the goal of developing a completely novel strategy of treating atherosclerosis.

PI_NAMEs: RAZANI, BABAK  (contact)

PROJECT_TERMS: Amino Acid Transporter;Amino Acids;Apolipoprotein E;Apoptosis;Apoptotic;Area;Arterial Fatty Streak;atherogenesis;atheroprotective;Atherosclerosis;Autophagocytosis;Award;Biogenesis;Cardiovascular Diseases;Caring;Cause of Death;Cell Death;Cell Physiology;Cells;Cholesterol;Clinical;Complex;Coronary Arteriosclerosis;cytotoxic;Data;Deposition;Dietary Proteins;Disease;Event;experience;Functional disorder;Future;Genes;Goals;Heart failure;Hyperlipidemia;Hypertension;In Vitro;in vivo;Infiltration;Inflammasome;Inflammatory;insight;Investigation;Knockout Mice;Learning;Link;Lipids;Lysosomal Storage Diseases;Lysosomes;Macrophage;Measures;Mediating;Medical;Membrane;military veteran;Mitochondria;Modeling;Modification;Molecular Chaperones;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Infarction;Myocardial Ischemia;novel strategies;novel therapeutic intervention;Nutrient;Organelles;overexpression;oxidized low density lipoprotein;Pathway interactions;Phagocytosis;Phenotype;Process;protein aggregation;Publishing;Regulation;Regulatory Pathway;response;Risk Factors;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stroke;System;Testing;Therapeutic;transcription factor;Tropism;United States;Work

PROJECT_TITLE: Harnessing the Autophagy-Lysosomal Biogenesis Response in Macrophages to Treat Atherosclerosis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE The proposed research will delineate how chronic manganese exposure can impact neuropathological and cognitive changes in Alzheimer’s disease. This work is directly relevant to NIEHS’s mission to understand how the environment can directly impact public health and specific disease burden. Understanding the role of manganese in mechanisms of neurodegeneration will provide opportunities to delay disease onset or progression in order to extend the healthy, active years of life.

PI_NAMEs: BOWMAN, AARON B;HARRISON, FIONA EDITH (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: abeta accumulation;abeta oligomer;Acceleration;Address;Affect;Age;Age Months;Age of Onset;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;apolipoprotein E-4;Area;arginase;Astrocytes;Autopsy;Behavior;behavior test;Behavioral;Biochemistry;Biological Availability;Biological Markers;Brain;burden of illness;Cell Culture Techniques;Chicago;Chronic;Cities;Cognition;Cognitive;cognitive change;cognitive testing;Complex;contaminated water;Control Animal;Coupled;Cultured Cells;Data;Dementia;Development;Diet;Diffuse;Disease;Disease Marker;Disease Progression;disorder prevention;Electroencephalography;Electrophysiology (science);emotional functioning;Environment;Environmental Risk Factor;epidemiologic data;epidemiology study;Epilepsy;Epileptogenesis;Equilibrium;excitotoxicity;experimental study;exposed human population;Exposure to;Expression Profiling;familial Alzheimer disease;Food;Future;Gasoline;Genes;Genetic Predisposition to Disease;Genetic Transcription;glutamatergic signaling;Glutamates;Heterozygote;Homeostasis;Human;human data;human induced pluripotent stem cells;human stem cells;hyperphosphorylated tau;Immunohistochemistry;Impaired cognition;Impairment;Incidence;Industrialization;Inflammation;Inflammatory;inflammatory marker;Inhalation;Intervention;Kainic Acid;Knockout Mice;knowledge base;Learning;Life;Link;Long-Term Potentiation;Macaca;Manganese;Manganese Poisoning;Mass Spectrum Analysis;Measures;Memory;Methods;Mexico;middle age;mild cognitive impairment;Mission;Molecular;molecular marker;Motor;motor control;motor impairment;mouse model;Mus;Mutation;National Institute of Environmental Health Sciences;Nerve Degeneration;neural;Neurites;Neurodegenerative Disorders;neuroinflammation;Neuronal Differentiation;Neurons;neuropathology;neurotoxic;neurotoxicity;Neurotoxins;Neurotransmitters;Occupational Exposure;Onset of illness;Oral;Outcome;Oxidation-Reduction;Oxidative Stress;Parkinsonian Disorders;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Plants;Pollution;Population Control;Predisposition;presenilin-1;Primary Cell Cultures;Primates;Proteins;Public Health;Publishing;Regulatory Pathway;Research;Rodent;Role;Sampling;Seizures;Senile Plaques;Severities;Signal Transduction;Social Functioning;Source;species difference;Speed;stem cell model;subcutaneous;Symptoms;Synapses;System;Techniques;Telemetry;Testing;Therapeutic;Tissues;Toxic effect;Toxic Environmental Substances;TREM2 gene;Tremor;uptake;Wild Type Mouse;Work;young adult

PROJECT_TITLE: Manganese exposure susceptibility as a modifier of excitotoxicity in Alzheimer's Disease


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Immunization;Nutrition;Prevention;Vaccine Related;Vaccine Related - AIDS

PHR: PROJECT NARRATIVE Nutritional status may influence the qualities of immunity, including perhaps the effectiveness of defense against microbes. There are hints that this major factor in human health may involve the levels of key amino acids in the bloodstream, but a major technical obstacle has been that scientists cannot visualize relative levels of these nutrients or metabolites that can come from them in the micro-anatomy of organs where immune responses are generated and effected. The work we propose here will test how manipulations of supply or utilization of nutrients such as glutamine impact antibody responses after modeling vaccination, and use a novel approach to rigorously validate how these manipulations change the micro-environment in immune organs.

PI_NAMEs: BOOTHBY, MARK R (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: adaptive immunity;Affect;Affinity;alpha ketoglutarate;Amino Acids;Animal Experiments;Antibodies;Antibody Response;B cell differentiation;B Cell Proliferation;B-Lymphocytes;Biological;Blood Circulation;Cell Differentiation process;Cell Physiology;Cell Reprogramming;cell type;Cells;Chromatin;chromatin modification;Complex;Critical Illness;Data;Defect;density;deprivation;Development;Diet;Effectiveness;electric impedance;Elements;Endocrine;Epigenetic Process;Equilibrium;Experimental Models;experimental study;FRAP1 gene;Gene Expression Regulation;Generations;genomic locus;Glucagon Receptor;Glucose;Glutamates;Glutaminase;Glutamine;Haptens;Health;histone methylation;Histones;Human;Humoral Immunities;Hypoxia;IgE;IgG1;Image;Immune;Immune response;Immunity;Immunization;Immunoglobulin Class Switching;Impairment;In Vitro;in vivo;Infection;interstitial;Link;loss of function;lymph nodes;Lymphocyte;Lymphocyte Function;lymphocyte proliferation;Lymphoid;Lymphoid Follicle;Lysine;Malnutrition;Malpighian corpuscles;mass spectrometric imaging;Mass Spectrum Analysis;Mature B-Lymphocyte;Measures;Mediator;Memory;Memory B-Lymphocyte;Metabolic;Metabolism;Methylation;Microanatomy;Microbe;microbiome;Modeling;Molecular;Nature;novel;novel strategies;Nutrient;nutrition;Nutritional status;Organ;Outcome;oxidation;Patients;Pattern;Permeability;Physiological;plasma cell differentiation;Plasma Cells;Precursor B-Lymphoblast;Process;Proliferating;Protein Deficiency;Proteins;Regulation;Reporting;restraint;Rodent;Scientist;sensor;Set protein;Signal Pathway;Signal Transduction;Spleen;Structure of germinal center of lymph node;T-Lymphocyte;Testing;Vaccination;vaccine efficacy;Vaccines;Venous;virtual;Visualization;Work

PROJECT_TITLE: Manipulating & imaging nutrient micro-milieux as B cells effect humoral immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-J(03)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The Pediatric and Reproductive Environmental Health Scholars-Southeastern Environmental Exposures and Disparities (PREHS-SEED) mentored K12 career development scholars program will provide junior clinical faculty with comprehensive training in pediatric and reproductive environmental health research. Faculty scholars will collaborate with local community partners and the Region 4 Southeast Pediatric Environmental Health Specialty Unit (PEHSU)— a region burdened by systemic racism and climate-related environmental threats that intensify health disparities. Faculty scholars will conduct research to assess environmental health exposures and disparities in order to improve health equity and safeguard the health of at-risk women and children in the Southeastern United States.

PI_NAMEs: THOMPSON, LISA MARIE (contact)

PROJECT_TERMS: Address;African American population;Air Pollution;Area;Black race;career;career development;Caring;Child;Childhood;Climate;climate change;Clinical;Clinical Research;cohort;Color;Communities;community based research;community collaboration;community engagement;Dangerousness;Death Rate;Dedications;Deep South;environmental disparity;Environmental Exposure;Environmental Health;environmental health disparity;Event;experience;extreme heat;Face;Funding;Goals;Health;Health Disparities Research;health inequalities;Historically Black Colleges and Universities;Immigrant;Inequity;Infant Mortality;Informatics;Infrastructure;Institution;Interdisciplinary Study;Latinx;Low income;Maps;Maternal Mortality;medical specialties;Mentored Clinical Scientist Development Program;Mentors;Mentorship;metabolomics;Methodology;Morehouse School of Medicine;multidisciplinary;novel;Nursing Faculty;Outcome;Phase;Policies;Program Development;programs;Public Health Schools;recruit;Refugees;reproductive;Research;Research Methodology;Research Training;response;Scholars Program;Science;Scientist;Shame;skills;Southeastern United States;Time;Toxicology;Training;Training Programs;Translational Research;United States;Universities;Weather;Woman;Women's Health

PROJECT_TITLE: Pediatric and Reproductive Environmental Health Scholars Southeastern Environmental Exposures and Disparities (PREHS SEED) Program


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Disability Research;Genetics;Hearing Loss;Human Genome;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Project Narrative Age-related hearing loss (ARHL) or presbycusis, which is becoming increasingly common as the population ages, and the genetic basis of ARHL is not well-defined, however, Genome-wide Association studies (GWAS) are rapidly identifying new variants and candidate genes. To understand their role in ARHL, we will generate knockouts of candidate disease genes associated with ARHL in zebrafish to determine the functional consequence of such mutations in ARHL. Identifying the functional consequences of causal variants involving ARHL will be crucial in understanding the molecular basis of the disease that will ultimately be required for the development of therapeutics.

PI_NAMEs: VARSHNEY, GAURAV K (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Acoustics;Adult;Affect;Age;Alleles;Animal Model;Behavior;behavioral phenotyping;Biological Models;Candidate Disease Gene;candidate identification;causal variant;CDH23 gene;Complex;cost;CRISPR/Cas technology;Data;Development;Diagnosis;Dimensions;Disease;disease model;disease phenotype;Drug Screening;Dyes;Embryonic Development;Ensure;exome sequencing;Fertilization;gene function;Gene Silencing;Generations;Genes;Genetic;genome wide association study;genome-wide analysis;genomic locus;Goals;Hair Cells;Health;Hearing;Hearing Aids;hearing impairment;hearing loss phenotype;Human;In Situ Hybridization;Infection;Injury;inner ear development;insight;International;Investments;Knock-out;knockout gene;Label;Labyrinth;Larva;lateral line;Libraries;loss of function;Maps;Mechanoreceptors;Mediating;Messenger RNA;Methods;model organism;Molecular;Monitor;Morphology;mRNA Expression;Mutagenesis;mutant;Mutation;neuromast;neurosensory;next generation sequencing;Noise;novel;novel therapeutics;Orthologous Gene;ototoxicity;paralogous gene;Participant;Pathogenesis;Pathology;Patient Self-Report;Pattern;Persons;Pharmaceutical Preparations;Phenotype;Population;Presbycusis;Quality of life;Rehabilitation therapy;Reporter;Reporter Genes;Resources;Role;screening;spatiotemporal;Startle Reaction;Swimming;System;Technology;Testing;therapeutic development;Tissues;Transgenic Organisms;Variant;Visualization;Zebrafish

PROJECT_TITLE: Functional Analysis of GWAS loci associated with hearing loss.

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Estrogen;Infectious Diseases;Influenza;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pneumonia and Influenza;Pregnancy;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Infections during pregnancy produce inflammatory cytokines (such as type I interferon) which can lead to miscarriage or birth defects; unfortunately, there are no interventions capable of protecting the fetus from this inflammation. We have identified a previously uncharacterized signaling pathway, induced by the G protein- coupled estrogen receptor 1 (GPER1), that functions to prevent type I interferons produced during a maternal respiratory infection from compromising fetal development. The major goal of this application is to define how the basal activities of GPER1 normally protect fetal health so that this knowledge can eventually be leveraged to prevent poor pregnancy outcomes.

PI_NAMEs: HEATON, NICHOLAS S (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Adverse effects;Affect;airway epithelium;Cell Line;Cell Physiology;cell type;Circulation;Clustered Regularly Interspaced Short Palindromic Repeats;Congenital Abnormality;congenital infection;Coupled;cytokine;Cytoprotection;Data;Decidua;Decidual Cell;Defect;disabled;ESR1 gene;Estrogens;experimental study;fetal;Fetal Development;Fetal Growth;Fetal health;fetal infection;Fetal Tissues;Fetus;fetus cell;G Protein-Coupled Receptor Signaling;Gene Expression;Genetic Crosses;genome-wide;Goals;GPER gene;GTP-Binding Proteins;Health;Human;Immune;Immune response;in vivo;inducible Cre;Infection;Inflammation;Inflammatory;Influenza A virus;influenzavirus;innovation;insight;Interferon Receptor;Interferon Type I;Interferons;Intervention;intravital imaging;Knockout Mice;Knowledge;Lead;Link;longitudinal analysis;Low Birth Weight Infant;Maps;Maternal Health;Maternally-Acquired Immunity;Measurable;Mediating;Microscopy;mouse model;Mus;novel;novel therapeutic intervention;Organoids;pathogen;Pathway interactions;Patient Self-Report;Phenotype;Physiological;Placenta;Placental Biology;Placental Insufficiency;Positioning Attribute;Pregnancy;Pregnancy Outcome;Pregnant Women;prevent;Production;protective effect;protective pathway;receptor;Regulation;Regulatory Pathway;reproductive;Research;Respiratory Tract Infections;Signal Pathway;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Spontaneous abortion;stem cells;Structure;Surface;Therapeutic;therapy design;Tissue Sample;Tissues;trafficking;type I interferon receptor;Upper Respiratory Infections;Upper respiratory tract;Viral;Virus Diseases;Virus Replication;Work;ZIKV infection

PROJECT_TITLE: Control of influenza virus induced type I interferon signaling during pregnancy

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ORG_CITY: WOODS HOLE

ORG_NAME: WOODS HOLE OCEANOGRAPHIC INSTITUTION

ORG_STATE: MA

PHR: Project Narrative The mission of the Woods Hole Center for Oceans and Human Health is to protect the public health by: a) expanding our understanding of how climate and oceanic processes affect the population dynamics of key Harmful Algal Bloom (HAB) species, b) applying this information to predict how climate variability influences HABs and human exposure to toxins, and c) determining the scope and consequences of newly identified effects in the brain from exposure to potent HAB neurotoxins during development. Studies will focus on Alexandrium catenella and Pseudo-nitzschia spp. that produce the potent neurotoxins saxitoxin and domoic acid, respectively. Findings will be communicated, involving resource managers, stakeholders, students, health care providers and the public, to enhance understanding and disease diagnosis and improve public health.

PI_NAMEs: MCGILLICUDDY, DENNIS J (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Anatoxins;Arctic Regions;Awareness;Behavioral;Biological Models;Brain;Cell Differentiation process;Cell Size;cell type;Cells;cellular targeting;Climate;climate change;climate data;climate forcing;climate variability;Collaborations;Communication;Communities;community engagement;Community Health;Community Health Education;Coupled;Cyanotoxin;Cyst;Data;Development;Diagnosis;Disease;disease diagnosis;domoic acid;early life exposure;Education;Educational Materials;Embryo;Ensure;environmental change;Evaluation;experience;exposed human population;Exposure to;Future;future climate scenario;Geographic Locations;Geography;Goals;Growth;Habitats;harmful algal blooms;Health;Health Personnel;Health Professional;Human;human induced pluripotent stem cells;improved;In Situ;In Vitro;in vivo;insight;Institution;K-12 Education;Knowledge;Learning;Life;Life Cycle Stages;Link;literacy;Location;Longitudinal trends;Maine;Measurement;Mission;Modeling;Molecular;myelination;neural;neurobehavioral;Neuroglia;Neurons;Neurotoxins;novel;Oceans;Outcome;Paralysed;persistent organic pollutants;Physiological;Poisoning;Population;Population Dynamics;predictive modeling;Predisposition;prevent;Process;Production;programs;Proliferating;Public Health;Records;Recurrence;Regulation;Research;Research Project Grants;Resources;response;Risk;Sampling;Saxitoxin;Science;Severities;Shellfish;single-cell RNA sequencing;Structure;Students;Study models;Syndrome;synergism;System;Technology;Testing;Toxic effect;Toxin;Training;transcriptomics;Transgenic Organisms;Vulnerable Populations;Water;Zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LKB-K (P)]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions

PROJECT_TERMS: Address;Advisory Committees;Affect;archive data;Asia;Biological;Climate;climate change;climate data;Collaborations;Communication;Communities;community engagement;Community Health Education;Community Outreach;Computers and Advanced Instrumentation;contaminated seafood;data archive;data communication;data exchange;data submission;Development;Discipline;early life exposure;Ensure;Europe;Evaluation;exposed human population;Exposure to;Goals;Grant;harmful algal blooms;Health;health data;Health Personnel;Health Professional;Human;human model;Information Dissemination;Institution;International;Joints;Kinetics;Measurement;meetings;member;Methods;Mission;Modeling;Modernization;Monitor;National Institute of Environmental Health Sciences;neurobehavioral;Oceanography;Oceans;outreach;Policies;Privatization;Process;programs;Public Health;Recommendation;Records;Reporting;Research;Research Personnel;Research Project Grants;Resources;Risk;Role;Sampling;Science;Seafood;Series;Shellfish;Structure;success;synergism;Testing;Time;Toxin;web page;Work

PROJECT_TITLE: WHCOHH Administrative Core


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Social Determinants of Health

PI_NAMEs: RICHLEN, MINDY  (contact)

PROJECT_TERMS: Address;Adoption;Advisory Committees;Animals;Area;Awareness;Classification;climate change;climate-related health;Clinical;Collaborations;Communication;Communities;community engagement;Community Health;Data;data portal;data sharing;Development;Diagnosis;Disease;economic disparity;Education;Education and Outreach;Educational Activities;Educational Curriculum;Educational process of instructing;effectiveness evaluation;efficacy evaluation;empowerment;ethnic minority;Evaluation;experience;Exposure to;Fostering;Goals;Grant;harmful algal blooms;Health;Health Personnel;Health Professional;Health Sciences;Healthcare;Human;Image;improved;Infrastructure;innovation;K-12 Education;Knowledge;Lead;Logic;Maine;Medical;medical schools;meetings;Modeling;Monitor;neighborhood disadvantage;New England;next generation;Oceans;open source;Outcome;outreach;Poison;prevent;programs;Provider;Psychological Transfer;Public Health;racial minority;Recording of previous events;Recreation;Reporting;Research;Research Personnel;Resources;response;Risk;Science;Scientist;sensor;Services;Shellfish;Students;success;symposium;Technology Transfer;Time;Toxin;Training;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;underserved community;underserved students;Veterinarians;Visually Impaired Students;web server

PROJECT_TITLE: WHCOHH Community Engagement Core


PI_NAMEs: BROSNAHAN, MICHAEL  (contact)

PROJECT_TERMS: Address;asexual;Automobile Driving;Awareness;Beds;Biological;Biological Models;Biomass;Canada;Cell Size;Cells;Climate;climate change;climate impact;coastal water;Communities;community engagement;conditioning;Coupled;Cyst;Data;Diatoms;domoic acid;Ecosystem;Environment;Eukaryota;Event;exposed human population;Exposure to;Gametogenesis;Genetic Recombination;Geographic Locations;Germ Cells;Growth;Habitats;harmful algal blooms;Health;High Frequency Waves;Human;hydrography;improved;In Situ;Incubated;Individual;innovation;insight;Investigation;Life Cycle Stages;life history;Link;Location;Longitudinal trends;Maine;marine;Measurement;meetings;metatranscriptomics;Methods;Modeling;Neurotoxins;Nutrient;Oceanography;Oceans;online resource;Paralysed;Pattern;Physiological;Physiological Processes;Physiology;Phytoplankton;Poisoning;Population;pressure;Process;Production;Recording of previous events;Research;response;Rest;Ribosomes;Risk;sample collection;Sampling;Seasons;sensor;Series;Severities;sex;Shellfish;Ships;Source;spatiotemporal;Statistical Models;Stimulus;Structure;Study models;System;Telemetry;Temperature;Thinness;Time;Toxic effect;Toxin;trend;Uncertainty;Water;Work

PROJECT_TITLE: Project 1: Drivers of interannual and intrabloom toxicity dynamics in Gulf of Maine HABs


PI_NAMEs: RALSTON, DAVID K (contact)

PROJECT_TITLE: Project 2: Climate forcing of harmful algal blooms and toxicity exposure


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Endocrine Disruptors;Foodborne Illness;Neurosciences;Pediatric;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: ALURU, NEELAKANTESWAR  (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Adolescent;Adult;Affect;Agonist;Anatoxins;Animal Model;Astrocytes;Axon;base;Behavioral;Biological Models;biophysical model;Biophysics;Brain;Cell Differentiation process;cell type;Cells;cellular targeting;Chemical Exposure;Child;Climate;climate change;climate impact;coastal water;Collaborations;Conceptions;Consultations;Coupled;design;Development;Developmental Biology;developmental neurotoxicity;developmental toxicity;developmental toxicology;Disease;domoic acid;early life exposure;Embryo;Environment;exposed human population;Exposure to;Extracellular Matrix;Fishes;Food;future climate scenario;Gene Expression;Gene Expression Profile;gene regulatory network;Genetic Transcription;Glutamate Receptor;Guidelines;harmful algal blooms;Harvest;Health;Human;human induced pluripotent stem cells;improved;In Vitro;in vivo;Induced pluripotent stem cell derived human neuron;insight;Larva;late life;Life;Life Cycle Stages;life span;marine;model organism;Modeling;Molecular;Multipotent Stem Cells;myelination;nerve stem cell;Nervous System;neural;neural circuit;neurobehavioral;neurodevelopment;Neuroglia;Neurons;Neurophysiology - biologic function;neurotoxic;Neurotoxins;Nicotinic Receptors;Oceanography;Oceans;Oligodendroglia;Outcome;persistent organic pollutants;Persons;Polychlorinated Biphenyls;Predisposition;Proliferating;Public Health;Research;response;Risk;Saxitoxin;Seafood;single-cell RNA sequencing;Sodium Channel Blockers;Source;Statistical Models;stem cell differentiation;stem cells;Synapses;System;Targeted Toxins;Testing;Time;Tissues;Toxic effect;Toxic Environmental Substances;toxicant;Toxin;transcriptome sequencing;transcriptomics;Transgenic Organisms;voltage;Vulnerable Populations;Water;young adult;Zebrafish

PROJECT_TITLE: Project 3: Cellular and molecular mechanisms underlying effects from early life exposure to HAB toxins


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

PHR: Relevance Prostate cancer is the leading cause of cancer related death in veterans. Although significant progress has been made in treatment, “exceptional responses” are rare and there is currently no way to personalize care for the majority of men with this disease. This study will test the effectiveness of high dose testosterone, a drug with early evidence for responses across a range of genes involved in DNA repair and with excellent tolerance in patients with ATM or CDK12 inactivating alterations in their prostate cancers. If successful, this study could provide a means of predicting which veterans could benefit from more effective and less toxic therapy for metastatic, resistant prostate cancer.

PI_NAMEs: MONTGOMERY, BRUCE  (contact)

PROJECT_TERMS: Address;advanced prostate cancer;Adverse event;androgen independent prostate cancer;Androgen Therapy;Androgens;arm;Biological Markers;biomarker selection;bipolar patients;Cancer Etiology;Cancer Patient;Cessation of life;Clinical;Cohort Studies;Common Terminology Criteria for Adverse Events;Decision Making;deprivation;design;Disease;DNA Damage;DNA Repair;DNA Repair Disorder;DNA Repair Gene;DNA Repair Pathway;Dose;early detection biomarkers;effective therapy;effectiveness testing;efficacy evaluation;Fred Hutchinson Cancer Research Center;Future;Genes;Genomic Instability;Genomics;homologous recombination;Immunotherapy;improved;Incidence;indexing;International;Intramuscular Injections;Length;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Mutation;neoplastic cell;Older Population;Pathogenicity;Pathway interactions;patient population;Patient Selection;patient subsets;Patients;personalized care;Pharmaceutical Preparations;Phase;phase 2 study;Poly(ADP-ribose) Polymerase Inhibitor;Population;potential biomarker;predicting response;predictive marker;primary endpoint;Progression-Free Survivals;Quality of life;radiological imaging;Resistance;response;response biomarker;Safety;secondary endpoint;Severities;sound;study population;Subgroup;Surveys;Survival Rate;Testing;Testosterone;Therapeutic;Toxic effect;tumor;Universities;Veterans;Vulnerable Populations;Washington;Work;working group

PROJECT_TITLE: High-dose Testosterone in Men with Metastatic Castration-resistant Prostate Cancer and ATM or CDK12 deficiency


PHR: The goals of this proposal are to identify genes responsible for neurologic disorders that affect movement, including ataxias, parkinsonian disorders, hereditary spastic paraplegias, choreas and dystonias, and decifer the steps that lead from the altered genes to disease. Genetic diseases of the nervous system are relatively common in the Veteran population and the diseases studied in this research project are directly relevant to Veterans’ health. These disorders, and especially parkinsonian disorders and ataxia, disproportionately affect the aging Veteran population. By itself Parkinson's disease affects approximately one million individuals in the United States at an estimated annual cost of $52 billion. Knowledge gained from studies on the biologic causes of the inherited forms of diseases will also increase understanding of more common neurologic disorders and accelerate improvement in diagnosis, management, and treatment of these and related conditions. Therefore, a better understanding of genetic diseases is pertinent to the long-term VHA mission.

PI_NAMEs: ZABETIAN, CYRUS P (contact)

PROJECT_TERMS: Acceleration;Affect;Aging;analytical method;Ataxia;Autoimmunity;Autophagocytosis;Autopsy;Basic Science;Biochemical Pathway;bioinformatics tool;Biological;Biological Models;biomarker panel;Birds;Brain;Candidate Disease Gene;Categories;causal variant;cell type;Chorea;Chromosome Mapping;Clinical;Collaborations;Collection;Copy Number Polymorphism;cost;Data;Data Set;Development;Diagnosis;diagnostic accuracy;Disease;disease-causing mutation;DNA;Drosophila genus;Dystonia;Dystonic Disorder;Etiology;Evaluation;exome;exome sequencing;Family;Family member;fascinate;gene discovery;Gene Expression Profiling;gene product;Genes;Genetic;Genetic Diseases;Genetic Research;genetic risk factor;genetic technology;genome sequencing;Genomic Segment;Genotype;Goals;Health;Hereditary Dystonia;Hereditary Spastic Paraplegia;Heritability;Human;identity by descent;Idiopathic Parkinson Disease;Impairment;improved;In Vitro;in vivo Model;Individual;induced pluripotent stem cell;Inherited;interest;Intervention;Knowledge;Lead;Massive Parallel Sequencing;member;military veteran;Mission;Modeling;Molecular;Movement;Movement Disorders;mutant;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neurogenetics;Neuroglia;neuronal survival;Neurons;next generation sequencing;Pancytopenia;Parkinson Disease;parkinson's disease registry;Parkinsonian Disorders;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;patient - derived stem cells;patient derived induced pluripotent stem cells;Patients;Pattern;pharmacologic;Phenotype;Preventive;proband;Productivity;protein complex;protein protein interaction;Proteins;recruit;repository;Research Personnel;Research Project Grants;Research Proposals;research study;Resolution;Resources;Role;sample collection;Sampling;SNP array;Spastic Paraplegia;spasticity;stem cell model;success;Syndrome;synucleinopathy;targeted treatment;tau Proteins;Tauopathies;Techniques;Technology;Tissues;trafficking;transcriptome sequencing;transmission process;United States;vacuolar H+-ATPase;Validation;Variant;Veterans

PROJECT_TITLE: Genetic Movement Disorders: Etiologies and Pathogeneses


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Eating Disorders;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Nutrition

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE  Rising negative affect is a well-established momentary maintenance factor for binge eating, yet limitations inherent to ecological momentary assessment hinder the field’s capacity to detect risk for binge eating in response to negative affectivity. This study will use passive psychophysiological sensors to evaluate the momentary association between negative affect and binge eating with the goals of 1) improving upon EMA to accurately predict binge eating in real time and 2) quantitatively and qualitatively evaluating the feasibility and acceptability of wearable psychophysiological sensors among individuals with binge eating. The project will set the stage for future research to develop more effective just-in-time adaptive interventions for binge eating and improve treatment outcomes and access in this population.

PI_NAMEs: PRESSELLER, EMILY KELLEY (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: acceptability and feasibility;adaptive intervention;Adult;Affect;Affective;Algorithms;Arousal;Awareness;Behavioral Symptoms;Binge Eating;Binge eating disorder;Biological Markers;Bulimia;Cellular Phone;Classification;clinically significant;Cognitive Therapy;Communities;Conscious;Consumption;Data;Data Collection;design;Development;Devices;Diabetes Mellitus;Eating;Eating Behavior;Eating Disorders;Ecological momentary assessment;emotional symptom;experience;feeding;fitbit;Focus Groups;Food;Future;Goals;Health Services Accessibility;Heart Rate;heart rate variability;improved;Individual;Intervention;Investigation;Knowledge;Literature;loss of control over eating;machine learning algorithm;Maintenance;Measurement;Measures;Mental disorders;Methods;Modeling;negative affect;Nervous System;Neurobehavioral Manifestations;Obesity;Participant;Patient Self-Report;Patients;Physiological;Population;preference;psychiatric comorbidity;Psychophysiology;Public Health;recruit;Regulation;reinforced behavior;Reporting;Research;response;Risk;Role;sensor;Specific qualifier value;Surveys;Symptoms;Testing;Time;Treatment outcome;wearable data;wearable device;wearable sensor technology;wristband

PROJECT_TITLE: Using Wearable Passive Sensing to Predict Engagement in Binge Eating in Response to Negative Affect: A Multimethod Investigation of Predictive Utility, Feasibility, and Acceptability

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Healthy people exposed to environmental mutagens accumulate somatic mutations in most cells of the exposed tissues. In this project, we propose to develop an innovative computational approach that will allow noninvasive monitoring of mutational processes from environmental exposures in easily accessible normal tissues of healthy individuals. The proposed approach will open a plethora of opportunities for personalized cancer prevention by timely detection of mutagenic exposures allowing targeted interventions for reducing or eliminating these environmental exposures.

PI_NAMEs: ALEXANDROV, LUDMIL B (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: 4-Nitroquinoline-1-oxide;Aflatoxin B1;Algorithms;Aristolochic Acids;Benchmarking;Bioinformatics;Blood;Blood specimen;Cancer Etiology;cancer genome;Cancer Patient;cancer prevention;Cell Line;Cells;Characteristics;Chemicals;chemotherapy;Chronic;Cisplatin;Classification;clinical practice;cohort;combinatorial;computerized tools;Consumption;contaminated water;Custom;Data;Detection;Development;DNA Sequence;DNA sequencing;Environment;Environmental Exposure;environmental mutagens;Epidemiologist;Event;Experimental Models;experimental study;Exposure to;Future;Genome;Goals;Human;Human body;imprint;In Vitro;in vivo;Individual;innovation;Intercept;Intervention;Leukocytes;Life Style;Malignant Neoplasms;Measurement;Measures;Methodology;Monitor;mouse model;Mutagens;Mutation;Mutation Detection;non-invasive monitor;Normal Cell;Normal tissue morphology;novel;novel strategies;Outcome;Passive Smoking;Patients;Pattern;Persons;Platinum;prevent;Process;Research;Risk;Sampling;Somatic Cell;Somatic Mutation;Source;Surveys;System;Testing;Tissues;Validation;Water consumption

PROJECT_TITLE: Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer Prevention


ORG_CITY: White River Junction

ORG_NAME: WHITE RIVER JUNCTION VA MEDICAL CENTER

ORG_STATE: VT

PHR: Depression is very common, costly and disabling, especially within the VA. Although there are potentially effective treatments for depression, many patients do not respond adequately to these. Transcranial magnetic stimulation (TMS) is a novel intervention for depression that is available in the VA through a Clinical TMS Pilot Program. Many patients with treatment-resistant depression respond well to TMS, but many do not. TMS likely works by altering how certain regions of the brain communicate with each other. Electroencephalography (EEG) can provide a measure of how various brain regions are functioning and communicating with one another. By enrolling patients receiving treatment in the TMS Pilot Program, this study will test EEG-based markers of brain function that predict response to TMS for depression. Additionally, this study will create a large, multi-site research infrastructure that will allow identification and testing of EEG markers of treatment response in a large Veteran group receiving TMS for depression.

PI_NAMEs: HOLTZHEIMER, PAUL  (contact)

PROJECT_TERMS: anti-depressive agents;Area;Biological Markers;Brain;brain electrical activity;Brain region;Clinical;Communication;cost;Deep Brain Stimulation;Devices;disability;Disabling;Disease remission;effective therapy;Electroencephalography;Electromagnetics;Enrollment;evidence base;expectation;functional restoration;Future;Goals;Grant;Infrastructure;infrastructure development;Intervention;inventory of depressive symptomatology;large datasets;Left;Machine Learning;Major Depressive Disorder;Measures;Mental Depression;Methods;mood regulation;mortality;network dysfunction;neural circuit;neural network;novel;novel strategies;participant enrollment;Patients;Pattern;personalized medicine;Pharmaceutical Preparations;Post-Traumatic Stress Disorders;potential biomarker;predicting response;predictive marker;Prefrontal Cortex;programs;Psychotherapy;Research;Research Infrastructure;Research Personnel;response;response biomarker;Rest;ROC Curve;Sampling;Severities;Site;Testing;therapy development;Time;Transcranial magnetic stimulation;treatment planning;treatment response;treatment-resistant depression;Veterans;Work

PROJECT_TITLE: Assessing an electroencephalography (EEG) biomarker of response to transcranial magnetic stimulation for major depression


NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative: The studies proposed here are relevant to public health for three reasons. First, they will allow us to identify individual and organic toxicant mixtures associated with ASD prior to the onset of clinical signs, as possible causal agents. Second, they will allow the discovery of exogenous and endogenous metabolites, and biological responses associated with ASD prior to the onset of clinical signs, so that we can objectively identify potential causal pathways and markers that can serve as the foundation for treatment strategies. Third, the temporal resolution afforded by the novel tooth biomarker technology allows us to identify the sensitive life stages for metabolic perturbations and toxicant exposures in fetal and neonatal development most strongly associated with ASD risk.

PI_NAMEs: PETRICK, LAUREN  (contact)

PROGRAM_OFFICER_NAME: LAWLER, CINDY P

PROJECT_TERMS: 1 year old;Address;Affect;Animals;autism spectrum disorder;autism symptoms;Autopsy;Behavioral;Biochemical;Biological;Biological Markers;biological systems;Biology;Biometry;Birth;Blood;Brain;California;Case/Control Studies;Chemical Models;Chemicals;Child;Child Health;Childhood Autism Risks from Genetics and the Environment;Clinical;cohort;Data;Dental;Development;Developmental Biology;Developmental Delay Disorders;Diagnosis;Disease;disorder risk;early life exposure;Emerging Technologies;Environment;environmental chemical;environmental chemistry;Environmental Exposure;Environmental Risk Factor;environmental stressor;Epidemiology;Etiology;Event;Exposure to;fetal;Foundations;Funding;Genetic;Growth;Health;high dimensionality;in utero;In Vitro;Incidence;Individual;infancy;Late pregnancy;Life;Link;Measurement;Measures;Medical;Metabolic;Metabolism;metabolomics;metal metabolism;Metals;Methodology;Methods;mother nutrition;Neonatal;Newborn Infant;novel;Nutrient;Onset of illness;organochlorine pesticide;Outcome;Participant;Pathogenesis;Pathway interactions;Phenotype;phthalates;polybrominated diphenyl ether;population based;postnatal;postnatal period;Pregnancy;prenatal;prenatal exposure;Prevalence;prevent;Public Health;Questionnaires;Research;Research Design;response;Sample Size;Sampling Studies;Second Pregnancy Trimester;Source;Statistical Methods;Stress;study population;Sum;Techniques;Technology;temporal measurement;Therapeutic;Third Pregnancy Trimester;Tooth Diseases;Tooth structure;Toxic effect;toxicant;Toxicant exposure;Toxin;treatment strategy;Trees;Twin Multiple Birth;Umbilical Cord Blood;United States National Institutes of Health;Work

PROJECT_TITLE: Environmental chemical mixtures and metabolomics in autism spectrum disorder

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Biotechnology;Climate-Related Exposures and Conditions;Clinical Research;Digestive Diseases;Food Allergies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Emerging evidence suggests that early-life environmental exposures are contributing to the increasing prevalence of allergic diseases including food allergy. In this proposal, we will investigate how exposures to environmental agents within the home, such as microbial products and air pollutants, influence peanut allergy development. This research will elucidate the role of the indoor exposome in food allergy development and help guide environmental remediation strategies aimed at reducing food allergy risk in children.

PI_NAMEs: MORAN, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Adjuvant;Agonist;Air Pollutants;airway epithelium;Allergens;Allergic;Allergic Disease;Allergy to peanuts;Anaphylaxis;Animal Model;Antigens;aspirate;Automobile Driving;B-Lymphocytes;biomass smoke;Birth;bronchial epithelium;career;Cell Culture System;Cell Line;Child;Childhood;coarse particles;Cohort Studies;Cutaneous;cytokine;Data;Dendritic Cells;Developed Countries;Development;Diesel Exhaust;Dust;environmental agent;Environmental Exposure;environmental intervention;Environmental Risk Factor;Epidemic;Epithelial Cells;Exposure to;fine particles;Food;food antigen;Food Hypersensitivity;Future;Helper-Inducer T-Lymphocyte;Home;Human;IgE;Immune signaling;immune stimulatory agent;Immunologics;indoor dust;Infant;Infiltration;Inhalation;Inhalation Exposure;Interleukin-1;Life;Ligands;Lung;lymph nodes;Measures;Mediating;microbial products;migration;Modeling;mouse model;Mucous Membrane;Mus;National Institute of Environmental Health Sciences;novel;particle;Particulate Matter;Prevalence;prevent;Production;programs;Receptor Signaling;remediation;Reporter;Reporting;Research;Research Priority;Respiratory System;Risk;Risk Factors;Role;Sampling;sensitizing antigen;Signal Pathway;Signal Transduction;Signaling Molecule;Skin;Source;Strategic Planning;T-Lymphocyte;Toll-like receptors

PROJECT_TITLE: Role of the indoor exposome in peanut allergy development


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative The goal of our studies is to learn how aging effects our immune cells and responses to influenza vaccination so that we can reverse the declines with aging and restore a youthful vaccine response. We will compare the seasonal influenza vaccine responses in a group of around 100 each young (40yrs) and older (65yrs) adults by analyzing their blood to determine how their immune cells change with age and how these changes affect our vaccine responses. We will use the knowledge gained from these studies to perform laboratory experiments in which we treat older immune cells with immune modulators and small molecules to see if we can restore immunologic and metabolic function to overcome age-related defects in vaccine responses.

PI_NAMEs: MARASCO, WAYNE A. (contact)

PROJECT_TERMS: Adjuvant;Adult;Affect;Age;age effect;age related;age related changes;age related decline;Age Years;Aging;aging population;anti-influenza;Antibodies;Antibody Response;Antigens;B-Lymphocyte Subsets;B-Lymphocytes;Biogenesis;Blood;Blood specimen;Carbon;Cause of Death;Cells;Cessation of life;Characteristics;Coculture Techniques;cohort;Cryopreservation;Defect;Elderly;Epitopes;Evaluation;experimental study;Formulation;Functional disorder;Functional impairment;Goals;Hemagglutinin;Heterogeneity;Hospitalization;human old age (65+);Humoral Immunities;Immune;Immune System Diseases;immune system function;Immunization Programs;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;Immunologics;Immunomodulators;imprint;improved;In Vitro;Individual;infection risk;Influenza;Influenza vaccination;influenza virus vaccine;Intervention;Knowledge;laboratory experiment;Learning;Mediating;Memory B-Lymphocyte;Metabolic;metabolic abnormality assessment;Metabolic Pathway;metabolic profile;Metabolism;metabolomics;Mitochondria;Molecular;novel;older adult;Older Population;Participant;Persons;pharmacologic;Plasma;Pneumonia;Population;Principal Investigator;recruit;response;restoration;Sampling;seasonal influenza;Serology;single cell genomics;small molecule;Specificity;T-Lymphocyte;Techniques;Testing;Time;transcriptome;transcriptomics;Translating;United States;Vaccination;Vaccine Antigen;Vaccine Design;vaccine formulation;vaccine response;vaccine-induced antibodies;Vaccinee;Vaccines;Writing;young adult

PROJECT_TITLE: Identification of Metabolic and Immune Deficits in the Aged Population and Their Restoration to Achieve Youthful Anti-Influenza Vaccine Responsiveness


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Contraception/Reproduction;Dietary Supplements;Health Effects of Indoor Air Pollution;Maternal Health;Nanotechnology;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: PROJECT NARRATIVE The utero-placental circulations are specifically designed to regulate the flow of blood and transport of essential nutrients to the fetus; this coordinated exchange is highly susceptible to disruption from environmental exposure, which can result in miscarriage and intrauterine growth restriction (IUGR). Unfortunately, the vascular and endothelial-dependent mechanisms by which utero-placental blood flow is reduced in IUGR are unknown, resulting in few treatment options beyond preterm delivery. We will use our model of environmentally-inducible IUGR to reveal novel mechanisms of altered hemodynamic molecular signaling that contribute to the development of IUGR as well as test nutritional interventions to mitigate IUGR severity.

PI_NAMEs: STAPLETON, PHOEBE  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: absorption;Acute;Aerosols;Air Pollution;Airborne Particulate Matter;Animals;Arachidonic Acids;arteriole;Attenuated;Biological Availability;Blood flow;Blood Vessels;Cardiovascular Diseases;Child;Chronic;Circulation;Clinical;constriction;cost;Data;Decidua Basalis;design;Development;dietary;Dietary Intervention;Diffusion;Dose;Eicosanoids;Endothelial Cells;Endothelium;Environment;Environmental Exposure;epidemiology study;Epoprostenol;Equilibrium;Evaluation;exhaust;Exposure to;fetal;fetal blood;Fetal Death;Fetal Development;Fetal Growth;Fetal Growth Retardation;Fetal health;fetal loss;Fetal Malnutrition;Fetal Weight;Fetus;fetus hypoxia;fine particles;folic acid metabolism;folic acid supplementation;Gases;Generations;Goals;Growth;healthy pregnancy;hemodynamics;Impairment;improved;In Vitro;Inhalation;innovation;insight;Intervention;intravital microscopy;Laboratories;late life;Left;Low Birth Weight Infant;Maternal Exposure;Maternal-fetal medicine;mechanical signal;Metabolic Diseases;Metabolism;Methodology;Microvascular Dysfunction;Modeling;Molecular;Mothers;Myography;nano;nanomaterials;nanosized;neonatal morbidity;Neonatal Mortality;Nitric Oxide;novel;novel strategies;Nutrient;Oxygen;particle;Particulate;Particulate Matter;Pathogenesis;patient population;Patients;Perfusion;pharmacologic;Pharmacological Treatment;Physiology;Placenta;Placental Circulation;Predisposition;Pregnancy;pregnant;Pregnant Women;Premature Birth;Preparation;pressure;prevent;Production;Prostaglandins I;Qualifying;Rattus;Regulation;Research;Resources;response;Risk;Risk Factors;Rodent Model;Role;Severities;Signal Transduction;skills;Spontaneous abortion;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Thromboxane A2;titanium dioxide;Toxic effect;Toxic Environmental Substances;Toxicant exposure;Treatment Efficacy;ultrafine particle;Uteroplacental Circulation;Uterus;Vascular Endothelium;vasoconstriction;Vasodilation;Vasodilator Agents;Work

PROJECT_TITLE: Microvascular mechanisms of growth restriction after environmental toxicant exposure


ORG_CITY: AMHERST

ORG_DEPT: CHEMISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE Per- and polyfluoroalkyl substances (PFASs) are highly stable and toxic chemicals that can cause adverse human health effects (e.g. increased risk of Type 2 diabetes and liver cancer). The goal of this proposal is to develop a treatment system that combines nanotechnology with microbial degradation to achieve complete destruction of PFASs without the production of toxic byproducts. The fundamental knowledge obtained from this study will provide critical information needed in developing efficient strategies to eliminate deleterious effects of PFAS in the environment.

PI_NAMEs: AGA, DIANA S (contact)

PROJECT_TERMS: Acids;Aftercare;Amino Acids;Bacteria;Binding;bioaccumulation;Biocompatible Materials;Biodegradation;Bioremediations;Blood;Carbon;catalyst;Characteristics;chemical association;Chemicals;Chromatography;Communities;consumer product;Couples;Degradation Pathway;dehalogenation;design;Development;Docking;drinking water;efficacy evaluation;efficacy testing;Environment;Environmental Pollution;Enzyme Interaction;Enzymes;Equilibrium;Evolution;Excision;exposed human population;Exposure to;Fluorine;Genes;Genetic Transcription;Goals;graphene;ground water;halogenation;Hazardous Chemicals;Health;Human;Hybrids;Hydrogen Peroxide;improved;in silico;individualized medicine;Industrialization;innovation;insight;Ions;Iron;Kidney;Kinetics;Knowledge;Length;Link;Liquid Chromatography;liver injury;Malignant neoplasm of liver;Malignant Neoplasms;Mass Spectrum Analysis;Measurable;Measures;Metagenomics;metallicity;Metals;microbial;microbial community;microbial genome;Microbiology;microbiota;microorganism;mineralization;Modeling;Molecular;molecular dynamics;molecular modeling;nano;nanomaterials;Nanotechnology;Natural Substance;NMR Spectroscopy;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;oxidation;Oxidation-Reduction;Oxides;Pathway interactions;Persons;Plants;Poison;Poly-fluoroalkyl substances;prevent;Production;Property;Public Health;Reaction;remediation;Research;Resolution;Risk;rRNA Genes;Site;Site-Directed Mutagenesis;Source;Structure;Surface;System;Techniques;Technology;Testing;titanium dioxide;tool;Toxic effect;Toxicokinetics;Training;transcriptomics;Treatment Step;ultraviolet irradiation;Validation;Work

PROJECT_TITLE: Model-aided Design and Integration of Functionalized Hybrid Nanomaterials for Enhanced Bioremediation of Per-and Polyfluoroalkyl Substances (PFASs)


ORG_CITY: College Station

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: Project narrative The research aims to address the significant challenges of persistent organic pollutants (POPs) remediation using Nanomaterial-Fungus Framework (NFF) through material design and mechanism study. The NFF contains a scaffold that absorbs trace level POPs rapidly, supports fungal growth, and stimulates the expression of oxidative enzymes for efficient bioremediation. The study will elucidate fundamental mechanisms for fungal bioremediation and offer an innovative stimulating material to enhance efficiency, enabling broad applications for remediation of diverse POPs.

PI_NAMEs: DAI, YUAN  (contact);LOWRY, GREGORY VICTOR;YUAN, JOSHUA S

PROJECT_TITLE: Efficient Bioremediation of Environmentally Persistent Contaminants with Nanomaterial-Fungus Framework (NFF)


ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: Project Narrative Both chlorinated volatile organic compounds (CVOCs) and 1,4-dioxane are potential or known human carcinogens. 1,4-dioxane, an emerging contaminant above the health-based reference level in 6.9% of the U.S. public water supplies, is commonly found to co-occur with CVOCs in contaminated groundwater including Superfund sites. This project aims at enhancing the remediation of 1,4-dioxane or its mixture with CVOCs by combining novel macrocyclic materials for contaminant adsorption with bioremediation, and investigates the interactions among the adsorbents, microbes, and contaminants.

PI_NAMEs: SHEN, YUEXIAO ;TANG, YOUNENG  (contact)

PROJECT_TITLE: Enhancing bioremediation of groundwater co-contaminated by chlorinated volatile organic compounds and 1,4-dioxane using novel macrocyclic materials


NIH_SPENDING_CATS: Eczema / Atopic Dermatitis;Infectious Diseases;Neurosciences;Nutrition;Pain Research;Prevention

ORG_CITY: WORCESTER

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Relevance Excessive type 3 cytokine response is responsible for psoriasis and eczema, a skin disorder involving impaired skin barrier integrity. Obesity, often driven by intake of high fat western diet, is one of the non-genetic factors associated with morbidity and severity of these two chronic inflammatory skin diseases. Despite major progress in understanding the immunological effect of dietary lipids, little is known about the molecular mechanism linking high fat diet to tissue inflammatory diseases. We have discovered that dietary cholesterol and its metabolites oxysterols shapes innate T lymphocytes resident in the skin that are equipped with sensors of altered oxysterol homeostasis. We will test the hypothesis that the fine specificity of skin positioning of these dermal T cells guided by oxysterols produced in a specialized skin niche is obligatory for proper immune reactions. Skin-homing innate T cells are imprinted to sense cholesterol byproducts during their development in the thymus and we will seek to decipher the molecular features controlling T cell-thymic niche crosstalk. This project will establish the functional importance of tissue cholesterol metabolism to achieve mucosal tissue immune homeostasis and provide new intervention strategies to treat inflammatory disorders in the skin, lung and gut.

PI_NAMEs: KANG, JOONSOO  (contact);REBOLDI, ANDREA

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: 25-hydroxycholesterol;Acute;Anatomy;Arthritis;Atopic Dermatitis;Autoimmune Diseases;Binding Proteins;Biochemical;Birth;Cell Communication;Cell Maintenance;Cell Physiology;cell type;Cells;Cholesterol;Cholesterol Homeostasis;chronic inflammatory skin;commensal bacteria;Communication;Cues;Cutaneous;cytokine;Cytokine Receptors;Data;Dermal;Dermis;Development;Diet;Diet Modification;dietary;Dietary Cholesterol;Dietary Fats;Disease;Eczema;Ensure;Enzymes;Epidermis;Epithelial Cells;Epithelium;Fatty acid glycerol esters;fitness;Food;Fortification;Funding;G-Protein-Coupled Receptors;Generations;Genetic Transcription;High Fat Diet;Homeostasis;Homing;Human;Hyperactivity;IL17 gene;Immune;Immunity;Immunologics;immunoreaction;immunoregulation;Impairment;imprint;Incidence;Infection;Infectious Skin Diseases;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;innovation;insight;Intake;interleukin-22;Intervention;keratinocyte;Knowledge;Ligands;Link;loss of function;Lung;Lymphocyte;Lymphoid Cell;Maintenance;Maps;Mediating;Metabolic;Metabolic Diseases;Microanatomy;Mixed Function Oxygenases;Modeling;Molecular;Morbidity - disease rate;mouse model;Mucous Membrane;Mus;Neuroglia;Neurons;Nociceptors;non-genetic;novel;Nutritional;Obesity;oxysterol 7-alpha-hydroxylase;Pain;pathogen;Pathway interactions;Pattern;Peripheral Nerves;Positioning Attribute;Pregnancy;prevent;Probability;Process;Production;Psoriasis;Regulation;Reporter;response;Response Elements;Rest;Schwann Cells;sensor;sensory integration;sensory mechanism;Sentinel;Severities;Shapes;Skin;skin barrier;skin disorder;skin organogenesis;SOX4 gene;Specific qualifier value;Specificity;Sterols;Stromal Cells;System;T-Lymphocyte;Testing;Thymic epithelial cell;thymocyte;Thymus Gland;Tissues;trait;transcription factor;western diet;γδ T cells

PROJECT_TITLE: Cholesterol metabolites coordinate skin barrier immunity centered on innate dermal gammadelta T cells programmed to produce IL-17

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(57)]


NIH_SPENDING_CATS: Cerebrovascular;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: PROJECT NARRATIVE We have learned that capsule serotype influences the translocation rate of Streptococcus pneumoniae across vascular endothelial cells (VEC) and into organs during bacteremia. Herein we will examine how capsule impacts attachment, receptor mediated endocytosis, resistance to intracellular killing, and S. pneumoniae trafficking to the basolateral surface of VEC for organ invasion. Our results will directly impact risk assessment strategies for escape from serotype-based vaccine design.

PI_NAMEs: ORIHUELA, CARLOS J (contact);TUOMANEN, ELAINE I

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acetylation;Adhesions;Affect;anti-microbial peptide;Bacteremia;Bacteria;Bacterial Adhesins;Bacterial Translocation;Binding;Binding Proteins;Biochemical;Blood Circulation;Brain;brain endothelial cell;capsule;Cardiac;Cell Wall;Cells;cerebrovascular;Cessation of life;Choline;Complex;Convalescence;Critical Pathways;Dependence;Disease;Encapsulated;Endosomes;Epidemiology;Epithelium;Event;Evolution;Excision;extracellular;frailty;Genetic;Goals;Heart;Hospitalization;Human;Impaired cognition;In Vitro;in vivo;Invaded;Kinetics;Laminin Receptor;Learning;Lesion;life span;Ligands;Lysosomes;Mechanics;Mediating;member;Membrane Proteins;Molecular;Mucous Membrane;Mus;mutant;N-Acetylmuramoyl-L-alanine Amidase;novel;Organ;Organ failure;Oxidative Stress;pathogen;Pathogenicity;Pathway interactions;Penetration;Peripheral;Phosphorylcholine;platelet activating factor receptor;Pneumococcal Infections;Process;Publishing;receptor;receptor mediated endocytosis;Receptor Signaling;Recycling;Research;Resistance;Risk Assessment;Role;Serotyping;Signal Transduction;Streptococcus pneumoniae;Structure;Surface;Testing;trafficking;uptake;Vaccine Design;Vascular Endothelial Cell;Vascular Endothelium;Virulence;Virulence Factors

PROJECT_TITLE: Molecular mechanisms underlying organ penetration in disseminated pneumococcal infection

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Multidrug resistant tuberculosis is a growing threat that urgently requires new therapeutic strategies. Here, we develop complementary biomimetic technologies that, when paired, selectively kill tuberculosis pathogens to rapidly clear drug-resistant pulmonary disease and inhibit transmission.

PI_NAMEs: MEDINA, SCOTT HAMMOND (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: absorption;Acute;Address;aerosolized;Aerosols;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Effect;Antimycobacterial Agents;Antitubercular Agents;Antitubercular Antibiotics;Artificial Intelligence;Bacteria;bactericide;Bacteriology;Bacteriolysis;Base Sequence;Binding;Biochemical Pathway;Biocompatible Materials;Biodistribution;Biological Assay;Biological Availability;Biomimetics;Body Weight;Cells;Chronic;Clinical;combinatorial;conventional therapy;Data;Deposition;design;Development;Diagnosis;Disease;Dose;Drug Combinations;Drug Delivery Systems;Drug Interactions;Drug Kinetics;Drug resistance;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;effective therapy;efficacy testing;Electron Microscopy;Engineering;Epidemic;experimental study;Extracellular Matrix;fitness;Fluorescence;Fluoroquinolones;Formulation;genome sequencing;global health;Goals;Health Priorities;Histologic;Histology;Histopathology;Host Defense;Hyaluronic Acid;immunogenicity;improved;in vivo;Infection;Invaded;Kinetics;Knowledge;Lead;lead candidate;Life;Liquid substance;live cell microscopy;Lung;Lung Diseases;Macrophage;Measures;Membrane;Metabolic;Metabolism;Microbe;mimetics;Molecular;mouse model;Moxifloxacin;Mucociliary Clearance;Multi-Drug Resistance;multi-drug resistant pathogen;Multidrug-Resistant Tuberculosis;Mus;Mutation;MXD1 gene;Mycobacterium tuberculosis;Mycolic Acid;nanomolar;non-compliance;novel;novel therapeutic intervention;novel therapeutics;optimal treatments;particle;Particle Size;pathogen;Pathogenesis;Patients;Peptide Antibiotics;peptide drug;peptide structure;Peptides;Pharmaceutical Preparations;Pre-Clinical Model;Predisposition;prevent;Property;Proteins;Publishing;pulmonary function;Pulmonary Tuberculosis;Pulse Oximetry;Recurrence;Regimen;residence;Resistance;resistance frequency;resistance mechanism;resistant strain;respiratory;Respiratory Mechanics;Route;Safety;Scanning;screening;self assembly;Series;Serum;side effect;Structure;Structure of parenchyma of lung;synergism;synthetic peptide;System;Technology;Testing;Therapeutic;Time;Toxic effect;transmission process;Treatment Efficacy;Treatment Protocols;Tuberculosis;uptake;whole genome

PROJECT_TITLE: Biomimetic Peptide Aerosols for Rapid Clearance of Pulmonary MDR Tuberculosis

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]