ORG_CITY: STONY BROOK

ORG_DEPT: CHEMISTRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Despite the enormous resources committed to the development of new drugs, many drug candidates fail in human clinical trials. Novel approaches are thus needed to improve our ability to develop new drugs. This project will integrate the kinetics of drug action into the drug discovery paradigm thereby improving the ability to predict drug efficacy in humans.

PI_NAMEs: TONGE, PETER J (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Acetyl-CoA Carboxylase;Amino Acyl-tRNA Synthetases;Animal Model;Anti-Bacterial Agents;Antibiotics;Cell model;Clinical Trials;Complex;Computational Biology;Coupled;Development;drug action;drug candidate;drug discovery;drug efficacy;Drug Kinetics;Drug Modulation;Drug Targeting;Enzyme Inhibition;Enzyme Kinetics;Equilibrium;Event;Excision;Human;Human body;improved;In Vitro;in vivo;Infection;inhibitor;Kinetics;leucine-tRNA;Link;mathematical model;Molecular;N-acetylglucosamine deacetylase;novel strategies;novel therapeutics;Pharmaceutical Preparations;residence;Resources;Role;Safety;stem;structural biology;Structure;success;System;Therapeutic Agents;Time;Translations

PROJECT_TITLE: Mechanism of Slow Onset Enzyme Inhibition and Translation to Time-Dependent Drug Activity

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: The primary focus area of the project program addresses a clinical unmet need in the management of dopamine medication-refractory balance and gait problems, in particular freezing of gait, in Veterans with Parkinson disease (PD). The second focus area of the project addresses a critical gap in our understanding of how age-associated vestibular changes may affect motor freezing behaviors. The relevance of the project is that it tests a mechanistic hypothesis that age-associated vestibular changes play a specific role in freezing of gait in Parkinson's disease; positive findings in this study may generative novel vestibular rehabilitative interventions in PD veterans with freezing of gait.

PI_NAMEs: BOHNEN, NICOLAAS IDA (contact)

PROJECT_TERMS: Activities of Daily Living;Acute;Address;Affect;age related;age related neurodegeneration;Area;Behavior;Bilateral;Brain;Brain Pathology;caloric stimulation;Chronic;Clinical;clinical application;Clinical assessments;clinical practice;clinical translation;Communities;Cross-Sectional Studies;Data;deconditioning;Dedications;Denervation;Disabling;Dopamine;dopamine transporter;Eligibility Determination;Emerging Technologies;Equilibrium;Etiology;fall risk;falls;fear of falling;Feasibility Studies;feasibility trial;Freezing;Frequencies;Gait;Gait abnormality;Goals;Home;human old age (65+);improved;Intervention;Knowledge;Link;Long-Term Effects;Methods;Motor;motor function improvement;Movement;Nature;neglect;nerve supply;Neurodegenerative Disorders;novel;Older Population;Parkinson Disease;Participant;Pathologic;Persons;Pharmaceutical Preparations;Phase II Clinical Trials;Physical activity;Play;Population;portability;Positron-Emission Tomography;posture instability;Prevalence;programs;Quality of life;Refractory;Rehabilitation therapy;Research;Resistance;Rest Tremor;Risk Factors;Role;sedentary;Severities;Societies;Testing;translational impact;treatment responders;treatment response;Vestibular Diseases;Vestibular dysfunction;vestibular system;Veterans

PROJECT_TITLE: Vestibulopathy, imbalance and gait disturbances in Parkinson disease

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


FUNDING_MECHANISM: OTHERS

ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

ORG_STATE: CA

PHR: The VA treats more than 250,000 veterans with schizophrenia. Cardiovascular illness is the leading cause of premature death and cognitive deficits are the leading cause of functional impairment in schizophrenia. Stress induced changes in cardiovascular function may impact brain health and contribute to the neural deficits associated with psychiatric symptoms, including psychosis and cognitive deficits. This study examines the effects of cognitive stress on the heart and brain. Cardiovascular activity is measured from continuous blood pressure monitoring and neurovascular activity in the brain is assayed from simultaneously recorded EEG and fMRI. These studies may lead to the development of biomarkers of heat-brain health for more effective diagnosis and treatment in schizophrenia, psychiatric illness, and stress-induced cardiovascular disease in veterans.

PI_NAMEs: JACOB, MICHAEL  (contact)

PROJECT_TERMS: Acceleration;aging brain;Anatomy;Antipsychotic Agents;Arithmetic;Autonomic nervous system;Behavioral;Biological Assay;Biological Markers;biomarker development;Blood;Blood flow;Blood Pressure;Blood Pressure Monitors;Blood Vessels;Brain;brain health;brain research;Cardiac;Cardiac Output;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;career;cerebrovascular;Cessation of life;Clinical;Clinical Research;Cognition;Cognitive;Cognitive deficits;cognitive task;Collaborations;Communication;comorbidity;Coupled;Coupling;Development;Diagnosis;diagnostic biomarker;Disease;Doctor of Philosophy;Educational workshop;Electrocardiogram;Electroencephalography;executive function;experience;Functional disorder;Functional impairment;Functional Magnetic Resonance Imaging;Funding;Future;Genetic study;Goals;Heart;Heart Diseases;heart function;Heart Rate;hemodynamics;Hyperactivity;Impairment;Intervention;Investigation;Lead;Life Style;Link;Measures;Mediating;Mediation;Medical;Mental disorders;Mental Health;Mentors;Metabolic;Metabolic Diseases;Methodology;Methods;Modality;Modeling;moderate obesity;Monitor;multimodal neuroimaging;Myocardial dysfunction;Nervous System Physiology;neural;neuroimaging;Neuronal Dysfunction;Neurosciences;neurovascular;neurovascular coupling;novel;novel strategies;Oxygen;Participant;Pathology;patient stratification;Pharmaceutical Preparations;Pharmacotherapy;Physiology;Population;premature;Principal Investigator;Psyche structure;psychiatric symptom;Psychiatrist;Psychopathology;Psychoses;psychotic symptoms;recruit;Regulation;Research;Research Personnel;Resources;response;Rest;Risk;Role;Schizophrenia;Signal Transduction;Stimulus;Stress;Structure;Surveys;Symptoms;Tissues;tool;Training;Training Support;Veterans;Work

PROJECT_TITLE: Stressed heart-brain communication in Veterans with schizophrenia: neurovascular and autonomic mechanisms


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Suicide is a national crisis, especially among older Veterans for whom evidence-based suicide prevention efforts are lacking. This proposal responds to the national priority to develop and improve interventions for suicide prevention, with a focus on at-risk older Veterans. The randomized control trial will compare VA usual care, which is suicide safety planning, with brief Problem Solving Therapy and suicide safety planning. This study uses Problem Solving Therapy because it has support from our pilot data and from secondary data analysis from other studies for reducing late life suicide risk. This treatment also has support for alleviating two key risk factors for late life suicide risk, functional disability and executive dysfunction, and thus this study will examine how older Veterans with varying levels of functional disability and executive functioning respond to treatment to inform future targeted implementation. In accordance with national priorities, existing infrastructure in Problem Solving Training could be expanded to support more rapid VA-wide implementation.

PI_NAMEs: BEAUDREAU, SHERRY ANN (contact)

PROJECT_TERMS: active control;Address;Adult;Aftercare;age group;aged;Alcohols;Anxiety Disorders;Audiotape;Award;Behavior Therapy;Bipolar Disorder;Borderline Personality Disorder;Cessation of life;Clinical;Clinical Practice Guideline;Clinical Trials;Cognitive;Color;Columbidae;Communities;Craniocerebral Trauma;Data;Data Analyses;Dementia;demographics;Depressive disorder;diagnostic criteria;direct application;disability;Disability Evaluation;Distress;DSM-V;Educational process of instructing;efficacious treatment;efficacy evaluation;Elderly;Eligibility Determination;Emotional;Enrollment;Ensure;evidence base;Evidence based intervention;Evidence based practice;Evidence based program;Exclusion;Executive Dysfunction;executive function;Feedback;Feeling;Feeling hopeless;Feeling suicidal;follow-up;functional disability;Future;General Population;Goals;Hour;improved;Infrastructure;Intervention;late life;Living Wills;Mediating;Mediator;Medical;Mental Depression;Mental disorders;Mental Health Services;Modeling;older adult;optimism;Outcome;Participant;participant safety;Patients;Post-Traumatic Stress Disorders;Prevention;primary care clinic;Problem Solving;problem solving therapy;Protocols documentation;psychiatric comorbidity;Psychotherapy;psychotic symptoms;Publishing;Qualitative Methods;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;recruit;reducing suicide;Registries;Reporting;Research;Research Design;response;Risk;Risk Factors;Role;Safety;satisfaction;Schedule;secondary analysis;Services;Severities;Site;skills;stress management;Substance Use Disorder;Suggestion;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Supportive care;Symptoms;Terminal Disease;Testing;Training;Training and Infrastructure;treatment as usual;treatment effect;Treatment outcome;treatment response;Unconscious State;United States Substance Abuse and Mental Health Services Administration;Veterans;Work;World Health Organization Disability Assessment Schedule

PROJECT_TITLE: Reducing Suicide Risk in Older Veterans with Mental Health Disorders using Problem Solving Therapy


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Military service in young adulthood has been linked to increased risk for the development of cognitive impairment, Alzheimer’s disease, and other dementias in later life; however, mechanisms for this increased risk are currently unknown. We aim to examine whether combat exposure in young Veterans promotes risk factors for the development of cognitive impairment and Alzheimer’s disease in later life, and how these risk factors are associated with the classical cognitive and neuropathological features of this disorder including neural ‘disconnection’ through deterioration of structural and functional brain connectivity. This work will provide valuable insight into mechanisms that promote risk for late life cognitive disorders in combat exposed military Veterans.

PI_NAMEs: SALAT, DAVID H (contact)

PROJECT_TERMS: Acceleration;Age;age acceleration;aged;Aging;aging related;aging related disease;Alzheimer's Disease;Alzheimer's disease pathology;Amygdaloid structure;Amyloid;associated symptom;Behavioral;Biological;Biological Markers;Body mass index;Boston;Brain;Brain imaging;Caring;Center for Translational Science Activities;Cognition Disorders;Cognitive;cognitive function;cognitive performance;cognitive reserve;cohort;Cohort Studies;combat;Data;Dementia;Deterioration;Development;Diabetes Mellitus;Disease;disorder risk;emerging adult;Equipment and supply inventories;Exposure to;follow-up;functional independence;Funding;Generations;Health;Health Care Costs;Healthcare Systems;hypercholesterolemia;Hypertension;Impaired cognition;Impairment;insight;late life;Life Style;Link;Maps;Measures;Mediator;Medical;Memory;mild traumatic brain injury;Military Personnel;military service;military trauma;military veteran;Modeling;multimodality;Nerve Degeneration;Nervous System Disorder;neural;neural circuit;neuroimaging;neuromechanism;neuropathology;non-demented;Older Population;Participant;Pathology;Pathway Analysis;Physiological;Post-Traumatic Stress Disorders;Prevalence;Preventive measure;Principal Investigator;pro-aging;Procedures;Proxy;resilience;Rest;Risk;Risk Factors;Sampling;serial imaging;societal costs;Statistical Models;Stress;stress disorder;Structure;support network;Symptoms;System;tau Proteins;Testing;Trauma;trend;Veterans;Visit;Waxes;white matter;Work;young adult

PROJECT_TITLE: Impact of Combat Exposure on Structural and Functional Brain Connectivity and Risk forAlzheimer's Disease in Aging Veterans


PHR: Veterans with MCI have an elevated risk of developing dementia. As the development of dementia is likely multi-factorial, potential interventions should also be multi-factorial in design. Physical exercise and cognitive training have great potential as a combined intervention for the rehabilitation of memory and protection against neurodegeneration. Most the research on physical exercise and cognition has focused on traditional weight-bearing exercises. These trials, however, have excluded many older Veterans who were not able to participate due to physical comorbidities. Water-based exercise is an ideal alternative as it has minimal weight-bearing stress and thus accommodates those with physical comorbidities that would otherwise be excluded from or unable to fully engage in exercise. It is crucial to formally investigate water- based exercise and cognitive training so as to increase the access of this at-risk group to high quality clinical trials.

PI_NAMEs: FAIRCHILD, JENNIFER KACI (contact)

PROJECT_TERMS: access restrictions;active method;Activities of Daily Living;Address;Age;Alzheimer's Disease;Alzheimer's disease risk;Area;Attention;Biological;brain health;Brain-Derived Neurotrophic Factor;Cardiopulmonary;Cardiovascular Physiology;Cardiovascular system;Caring;Clinical;Clinical Trials;Cognition;Cognitive;cognitive benefits;cognitive function;cognitive training;comorbidity;comparative efficacy;cost;Data;demented;Dementia;design;Development;Education;Educational Materials;effective therapy;efficacious intervention;efficacy evaluation;Elderly;Epidemic;Exclusion;executive function;Exercise;exercise capacity;exercise program;exercise training;experience;flexibility;follow-up;Freedom;Functional impairment;Future;Gender;Genetic;Genotype;Guidelines;Healthcare Systems;Impaired cognition;Impairment;improved;Injury;Intervention;Knowledge;late life;lifestyle intervention;Light;Long-Term Effects;Measures;Mediating;Mediator;Medical;meetings;Memory;mild cognitive impairment;Movement;Muscle;Musculoskeletal;Nerve Degeneration;Neurodegenerative Disorders;Neuropsychology;non-demented;novel;older adult;Outcome;Oxygen Consumption;Participant;Persons;Pharmacological Treatment;Phase;Physical Exercise;Physical Fitness;Plasma;Populations at Risk;predicting response;Prevalence;prevent;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Rehabilitation therapy;Research;Risk;Short-Term Memory;Single-Blind Study;Stress;Structure;success;Testing;Training;Training Programs;Treadmill Tests;treatment arm;treatment as usual;treatment effect;treatment response;Veterans;Visit;Vulnerable Populations;Walking;Water;Weight-Bearing state

PROJECT_TITLE: Water-based Activity to Enhance Recall in Veterans: A Randomized Clinical Trial


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Heart Disease;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: DURHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Atrial fibrillation, a very common heart rhythm disorder, especially in older adults, increases the risk for a decline in cognitive function and the development of dementia. While the mechanisms by which atrial fibrillation results in brain injury are not well understood, we also do not know whether restoring regular heart rhythm using a technique called catheter ablation (a minimally invasive procedure in which the doctor advances a flexible thin tube through the blood vessels to the heart to stop abnormal electrical signals in the heart tissue) reduces the likelihood of developing cognitive decline or dementia. In the proposed study, we will determine whether restoring regular heart rhythm using catheter ablation leads to less long-term brain damage and dysfunction than using medications alone.

PI_NAMEs: MATHEW, JOSEPH P (contact);PICCINI, JONATHAN PAUL

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Ablation;Affect;Age;Alzheimer's Disease;Alzheimer's disease risk;Anti-Arrhythmia Agents;Anticoagulation;Arrhythmia;Atrial Fibrillation;Attention Concentration;Automobile Driving;Biological Markers;Blood Platelets;Blood Vessels;Brain;brain dysfunction;brain health;Brain Injuries;Brain region;Cardiac ablation;cerebral atrophy;cerebral hypoperfusion;Cerebral Infarction;Cerebral Ischemia;Cerebrovascular Circulation;cerebrovascular reactivity;Characteristics;Chronic Kidney Failure;clinical practice;Clinical Trials;Coagulation Process;Cognitive;cognitive function;cognitive performance;comorbidity;cost;Data;Dementia;dementia risk;Development;Diabetes Mellitus;Disease;Early Intervention;Elderly;Embolism;Endothelium;Enrollment;flexibility;General Population;Goals;gray matter;Health;Heart;Heart failure;heart rhythm;Hemorrhage;Hypertension;imaging biomarker;Impaired cognition;improved;Inflammation;Inflammatory;insight;ischemic injury;lifetime risk;Link;Maintenance;Maps;Measures;Metabolic;Methods;minimally invasive;mortality;Myocardial Infarction;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;Nervous System Trauma;Neurocognition;neurocognitive test;neuroimaging;neuroinflammation;Neurologic;Neurologic Dysfunctions;Neurological outcome;older adult;older patient;Older Population;Oral;Pathologic;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;Plasma;preservation;Prevalence;prevent;Procedures;Process;prospective;Reporting;Research;restoration;Risk;Risk Factors;Risk Reduction;Signal Transduction;Sinus;sound;Stroke;stroke risk;Techniques;Testing;Therapeutic Embolization;Thick;Thinness;Thrombin;Tissues;treatment optimization;Tube;vascular cognitive impairment and dementia;White Matter Hyperintensity

PROJECT_TITLE: Neurocognition and Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The discovery of CRISPR-Cas immune systems has revolutionized biology, enabling the development of groundbreaking tools in genome editing and molecular biology. In this work, I will reveal the molecular mechanisms that govern immunological memory acquisition by the type III-A CRISPR-Cas system, and will define its physiological importance during CRISPR-Cas defense and tolerance. Studying the underlying functions of CRISPR-Cas systems will not only increase our understanding of this biological system but could also lead to the development of applications that improve human health.

PI_NAMEs: AVIRAM, NAAMA  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Adaptive Immune System;Affect;Archaea;Autoimmunity;Bacteria;Bacterial Genome;Bacteriophages;Biochemical;Biochemistry;Bioinformatics;biological systems;Biology;Biophysics;career;Cells;Characteristics;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;cold shock protein;Communication;Complex;cost;CRISPR/Cas technology;Data;Development;DNA;DNA Repair;DNA Sequence;DNA-Directed RNA Polymerase;ds-DNA;Elements;Engineering;Environment;experimental study;fitness;Genes;Genetic;Genetic Transcription;Genome;genome editing;genome wide screen;Genomics;genotoxicity;Goals;Health;Human;Immune response;Immune system;Immunity;Immunologic Memory;Impairment;improved;Infection;insight;Integrase;Integration Host Factors;Invaded;Laboratories;Link;Location;Mediating;Memory;memory acquisition;Mentorship;Mobile Genetic Elements;Molecular;Molecular Biology;molecular diagnostics;nuclease;Nucleic Acids;Outcome;Pathogenicity;Physiological;Plasmids;Population;prevent;Process;promoter;recruit;recurrent infection;Research;Research Design;Ribosomal RNA;RNA;Role;Site;skills;Staphylococcus epidermidis;System;technology development;Testing;tool;Transcript;Transfer RNA;Universities;Work;Writing

PROJECT_TITLE: Molecular mechanisms of memory formation and tolerance in CRISPR-Cas systems


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: This proposal seeks to determine the molecular mechanism of anti-CD4 IgG-producing B cells and the epitope target from pathologic anti-CD4 autoantibodies from immune non-responders that drive poor CD4+ T cell reconstitution in treated HIV, which may be amenable to targeted interventions.

PI_NAMEs: JIANG, WEI  (contact)

PROJECT_TERMS: Accounting;Affinity;Antibodies;antibody-dependent cell cytotoxicity;Antibody-Producing Cells;antigen binding;Antigens;antiretroviral therapy;Area;Autoantibodies;Autoantibody binding;autoreactive B cell;Avidity;B-Cell Antigen Receptor;B-cell receptor repertoire sequencing;B-Lymphocytes;Binding;Biochemical;Blood specimen;CD4 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Count;Cell Death;Cell Line;Cell Physiology;Cells;Cessation of life;Characteristics;Clinical Data;Common Epitope;Cryopreservation;Data Set;Death Rate;Development;Disease Progression;Epitope Mapping;Epitopes;Failure;Fibrosis;Flow Cytometry;Gene Expression;Gene Expression Profile;Genes;Genomics;Goals;high risk;HIV;HIV Envelope Protein gp120;HIV Infections;HIV Seropositivity;Hospitals;Immune;immune activation;Immunoglobulin G;Immunologics;In Vitro;Individual;Inflammation;Influenza;inhibitor;Intervention;Investigation;latent HIV reservoir;latent infection;Light;Lymphatic;Mediating;Messenger RNA;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;Pathogenesis;Pathologic;Peripheral Blood Mononuclear Cell;Persons;Plasma;Population;prevent;Production;Property;Public Health;Publishing;Recovery;recruit;Reporting;Role;Signal Pathway;Signal Transduction;Sorting;Specificity;Surface;T cell reconstitution;T-Cell Activation;T-Cell Depletion;targeted treatment;Testing;Therapeutic;therapeutic target;Thymus Gland;TLR2 gene;TLR4 gene;transcriptome sequencing;Veterans;Work

PROJECT_TITLE: Investigate the mechanism of autoreactive B cell-mediated immunological failure despite virologic suppression in HIV-infected individuals on antiretroviral therapy


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: Multiple sclerosis (MS) and other immune-mediated diseases represent a significant healthcare challenge in veterans. In this study, we take our insights gained from years of work and apply them to dissect novel and poorly understood immune processes that underlie MS. In particular, we will focus on the interactions between CD4 effector T cells and their CD8 T-cell immune regulators to gain an understanding about why pathogenic CD4 effector T-cells may become resistant to immune suppression during a relapse of disease and how one can modulate both CD4 and CD8 T-cells to the greatest immune regulatory effect. These studies will allow us to gain a deeper understanding of immune dysregulation, with the goal of generating better immunotherapeutic strategies in the future.

PI_NAMEs: KARANDIKAR, NITIN J (contact)

PROJECT_TERMS: Acute;Address;Affect;American;Animal Model;Antigen-Presenting Cells;Arthritis;Autoimmune;Autoimmune Diseases;Autoimmunity;Biological Response Modifiers;Biology;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;central nervous system demyelinating disorder;Clinical;Communicable Diseases;comparison control;cytokine;cytotoxicity;Demyelinating Diseases;Disease;Dissection;effector T cell;Experimental Autoimmune Encephalomyelitis;Feedback;functional plasticity;Future;Goals;Healthcare;Human;Hypersensitivity;IL17 gene;IL2RA gene;Immune;Immune system;immunopathology;immunoregulation;Immunosuppression;Immunotherapeutic agent;In Vitro;in vivo;Inflammatory;insight;Insulin-Dependent Diabetes Mellitus;interest;Interleukin-12;Interleukin-6;Intervention;Malignant Neoplasms;Mediating;Memory;Modeling;Molecular Profiling;Multiple Sclerosis;multiple sclerosis patient;Mus;novel;Pathogenesis;Pathogenicity;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Phenotype;PPBP gene;Process;Publications;Publishing;receptor;Recurrent disease;Relapse;Resistance;Role;STAT3 gene;Stimulus;T cell differentiation;T cell response;T-Lymphocyte;TC1 Cell;Th1 Cells;Therapeutic;Therapeutic Intervention;Time;transcriptome;transcriptome sequencing;Veterans;Work

PROJECT_TITLE: Effector-Regulator Immune Interactions During Autoimmune Demyelinating Disease


PHR: This proposal will construct a national longitudinal cohort of Veterans to answer critical questions regarding the prevalence, patterns, and reasons for SARS-CoV-2 vaccine failure in real-world settings. This proposal will inform public health and clinical care guidance in the VA and the US.

PI_NAMEs: KELLY, JOHN DANIEL (contact);KEYHANI, SALOMEH

PROJECT_TERMS: 2019-nCoV;acute COVID-19;Age;Body mass index;booster vaccine;Case/Control Studies;Catchment Area;Cirrhosis;Clinical;clinical care;cohort;Collaborations;comparative;COVID-19;COVID-19 diagnosis;COVID-19 incidence;COVID-19 vaccination;COVID-19 vaccine;Data;data sharing networks;data warehouse;density;design;Diabetes Mellitus;Disease;Dose;effectiveness study;efficacy trial;Environmental Risk Factor;Epidemiology;epidemiology study;experience;follow-up;Future;Goals;Healthcare;high risk;Hospitalization;hospitalization rates;human old age (65+);Immune response;Immune system;Immunocompromised Host;Immunologics;Individual;Integration Host Factors;Israel;Laboratories;Longitudinal cohort;Manufacturer;Medicare;Messenger RNA;military veteran;mortality;Mutation;Natural History;novel vaccines;observational cohort study;Outcome;Pattern;Persons;Population;population based;Populations at Risk;Positioning Attribute;pragmatic study;Prevalence;primary care visit;programs;protective factors;Protocols documentation;Public Health;Reporting;response;Risk;Risk Factors;RNA vaccine;Sampling;SARS-CoV-2 genome;SARS-CoV-2 infection history;SARS-CoV-2 variant;Subgroup;Symptoms;System;Thinking;Time;unvaccinated;Vaccinated;Vaccination;vaccination outcome;vaccination protocol;vaccine delivery;vaccine effectiveness;vaccine efficacy;vaccine failure;vaccine trial;Vaccinee;Vaccines;Variant;variant of interest;variants of concern;Veterans;Viral;Viral Genome;Viral Vector;whole genome

PROJECT_TITLE: VAccine failure: natural history and determinants of post-vaccination Covid-19


ORG_CITY: OMAHA

ORG_NAME: OMAHA VA  MEDICAL CENTER

ORG_STATE: NE

PHR: Veterans with rheumatoid arthritis (RA) suffer from high rates of respiratory-related mortality, with much of this mortality attributable to interstitial lung disease (ILD). Despite advances in the treatment of RA, optimal treatment strategies for Veterans afflicted with RA-ILD are lacking, leading to poor long-term outcomes. Using real-world data from prospective cohorts of Veterans with RA-ILD, we will identify Veterans at risk for progressive RA-ILD through novel serum and genetic biomarkers and determine the comparative effectiveness and safety of RA treatments on ILD progression and survival. This study will inform the personalized management of Veterans with RA-ILD and serve as a vehicle to develop the PI into an independent VA clinical investigator.

PI_NAMEs: ENGLAND, BRYANT R (contact)

PROJECT_TERMS: Acetaldehyde;active comparator;Address;Adoption;Affect;aggressive therapy;Algorithms;Antibodies;antifibrotic treatment;arthritis therapy;attributable mortality;Autoantibodies;Award;Big Data;Biological;Biological Markers;Biological Products;Biological Response Modifier Therapy;career;Cessation of life;Characteristics;chronic autoimmune disease;Clinical;Clinical Investigator;Clinical Practice Guideline;Clinical Research;clinical translation;cohort;comparative effectiveness;comparative safety;compare effectiveness;cost;cytokine;Data;Data Linkages;Data Sources;Death Rate;design;disability;Disease;Disease Outcome;Disease Progression;Doctor of Philosophy;Effectiveness;Future;General Population;Genes;Genetic Markers;genetic variant;Goals;Health Care Costs;high risk;high risk population;Hospitalization;idiopathic pulmonary fibrosis;immunomodulatory therapies;improved;indexing;Individual;Inflammatory;inhibitor;innovation;Interleukin-8;Interstitial Lung Diseases;Joints;Lead;Link;Lung Diseases;Lung Transplantation;Malignant Neoplasms;Malondialdehyde;Matrilysin;Matrix Metalloproteinases;Medicare;meetings;Mentors;Mentorship;Methodology;Methods;Modeling;mortality;mortality risk;MUC5B gene;multidisciplinary;novel;novel therapeutics;Observational Study;optimal treatments;Outcome;Patient Selection;Patients;personalized management;personalized medicine;Pharmacoepidemiology;physically handicapped;physiologic model;Population;Positioning Attribute;predictive modeling;Premature Mortality;Productivity;Prognosis;prognostic;prognostic assays;Prognostic Marker;programs;prospective;Prospective cohort;Pulmonary Fibrosis;Pulmonary function tests;Quality of life;Reporting;Research;Research Personnel;Research Project Grants;respiratory;Respiratory Disease;Rheumatoid Arthritis;Risk;rituximab;Role;Safety;Selection for Treatments;Serum;Source;supplemental oxygen;TNF gene;tocilizumab;Training Programs;Translational Research;treatment strategy;Uncertainty;Veterans;Veterans Health Administration;Vital capacity;Work

PROJECT_TITLE: Improving the Management of Rheumatoid Arthritis-Associated Lung Disease in Veterans Using Real-World Data


ORG_CITY: PITTSBURGH

ORG_STATE: PA

PHR: Lung cancer is the #1 cause of cancer related deaths for Veterans, with a prevalence almost twice as high as the non-Veteran population. Adoptive cell transfer (ACT) therapy shows promise for lung cancer but requires surgical removal of solid tumor and expansion of immune cells which can result in suboptimal function. Malignant pleural effusions (MPE) in advanced lung cancer are drained and discarded for palliation, however they have an abundance of immune cells that are a readily accessible and could be used for ACT therapy. This application presents preliminary observations that MPE derived immune cells may harbor anti-tumor activity and proposes studies to understand the potential for using them for ACT therapy in lung cancer patients. These studies may become the foundation for a novel clinical trial using personalized immunotherapy to treat lung cancer in Veterans.

PI_NAMEs: DHUPAR, RAJEEV  (contact)

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Transfer;Aftercare;Autologous;Automobile Driving;Award;Benign;Bioenergetics;cancer cell;Cancer Etiology;cancer infiltrating T cells;Cancer Patient;CD8B1 gene;Cell Physiology;Cells;Cellular Metabolic Process;Cessation of life;Clinical;clinical application;Clinical Trials;cytokine;cytotoxicity;Data;Dichloroacetate;Disease;Drainage procedure;Effectiveness;effusion;Environment;Excision;exhaust;exhaustion;Foundations;Genus Hippocampus;glucose uptake;Glycolysis;Glycolysis Pathway;Immune;immune checkpoint blockade;Immune System Diseases;Immunotherapy;In Situ;Incubated;Indwelling Catheter;insight;Interferon Type II;Interleukin-15;Interleukin-2;interleukin-21;Leukocytes;Liquid substance;Malignant neoplasm of lung;Malignant Neoplasms;Malignant Pleural Effusion;malignant state;Mediator;Medical Waste;Melanoma;Metabolic;Metabolic dysfunction;metabolic fitness;Metastatic Melanoma;Mutation;neoantigens;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;Nutrient;Operative Surgical Procedures;Oxygen;Oxygen Consumption;palliate;palliation;Pathway interactions;Patients;Peripheral;Peripheral Blood Lymphocyte;personalized immunotherapy;Pharmaceutical Preparations;Phenotype;physical property;Pleural effusion disorder;Population;pre-clinical;Preparation;Prevalence;Production;programmed cell death protein 1;Proliferating;Protocols documentation;respiratory;response;Route;Site;Solid;Solid Neoplasm;Source;T cell receptor repertoire sequencing;T cell therapy;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;TFRC gene;Time;tumor;Tumor Burden;Tumor Expansion;tumor infiltrating lymphocyte therapy;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Veterans

PROJECT_TITLE: Novel Use of Malignant Pleural Effusion Resident T cells for Systemic Adoptive Cell Transfer in Veterans with Lung Cancer


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR:  PROJECT NARRATIVE  Johns Hopkins University is committed to leveraging the full spectrum of faculty and data in a multi- disciplinary training program for Biomedical Informatics and Data Science (BIDS). The BIDS program is structured around four tracks: Translational Bioinformatics, Clinical Research Informatics, Healthcare/Clinical Informatics, and Public Health Informatics. Opportunities for learning and application through well-funded research enrich this training experience.

PI_NAMEs: CHUTE, CHRISTOPHER G (contact);KHARRAZI, HADI

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Arts;Basic Science;Bioethics;Bioinformatics;Biomedical Engineering;biomedical informatics;clinical data warehouse;Clinical Informatics;Clinical Research;Clinical Sciences;cohort;computer science;Computers;COVID-19;Data;Data Analytics;Data Science;Education;Educational Curriculum;Engineering;Environment;Equilibrium;experience;Faculty;Fostering;Funding;Future;Grant;Health Sciences;Healthcare;Informatics;informatics training;Infrastructure;Instruction;Internal Medicine;Leadership;Medical Libraries;medical schools;Mentors;Methods;multidisciplinary;Patients;population based;precision medicine;programs;Public Health Informatics;Public Health Schools;Research;responsible research conduct;School Nursing;Schools;Science;Secure;Shapes;Structure;Students;Support System;Training;Training and Education;Training Programs;Translational Research;U-Series Cooperative Agreements;Universities;virtual environment;virtual machine;Work

PROJECT_TITLE: Johns Hopkins Training Program in Biomedical Informatics and Data Science


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE MicroRNAs (miRNA) are small RNA molecules that are important for controlling animal developmental, differentiation, and disease processes. We are investigating how the cellular levels of miRNAs are precisely controlled through regulation of their biogenesis and degradation. This research will reveal the pathological consequences related to dysregulated miRNA levels in disease and provide the basis for designing therapeutic molecular tools to control gene expression via miRNAs.

PI_NAMEs: XIE, MINGYI  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 3' Untranslated Regions;Address;Affect;Base Pairing;Binding Proteins;Biochemical;Biogenesis;bioinformatics pipeline;Biological Assay;Cell Line;Colorectal Cancer;Control Animal;Cultured Cells;Defect;Degradation Pathway;design;Development;Disease;DNA;Doxycycline;Engineering;Enzymes;Essential Genes;experience;Gene Expression;genetic information;HCT116 Cells;improved;In Vitro;Individual;Knowledge;Malignant Neoplasms;Messenger RNA;MicroRNAs;model organism;Molecular;Molecular Probes;Neurodegenerative Disorders;novel therapeutics;Pathologic;Process;Property;Proteins;Regulation;Research;RNA;Small RNA;Structure;Techniques;Therapeutic;Tissues;tool;Transcript;tumorigenesis;Untranslated RNA

PROJECT_TITLE: Molecular mechanisms for regulating microRNA levels in metazoans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: In Veterans with psychosis, there are high rates of cannabis use, despite its association with worse prognosis, acute exacerbation of psychotic symptoms, impaired cognition, longer hospitalizations, and elevated healthcare costs. As the legalization of cannabis increases, the misuse and potency of cannabis has also been increasing. Alarmingly, interventions for this population have shown minimal efficacy. This study aims to investigate neural synchrony related to cannabis use, as well as how neural synchrony and cannabis use relate to cognition, psychiatric symptoms, and function using simultaneous magnetoencephalography (MEG) and electroencephalography (EEG) in Veterans with psychosis. Findings will inform the VA community about the effects of cannabis in Veterans and has clinical translational utility in that its identification of regions of altered neural synchrony has the potential to inform the development of more efficacious, targeted interventions.

PI_NAMEs: MARTIN, ASHLEY SCHNAKENBERG (contact)

PROJECT_TERMS: Acute;Address;Agonist;Alzheimer's Disease;Antipsychotic Agents;Anxiety;Auditory;brain health;Cannabinoids;Cannabis;career;Clinical;clinical translation;CNR1 gene;Cognition;cognitive function;Cognitive remediation;commercialization;Communities;Connecticut;Corpus striatum structure;Data;design;Development;Disease;effective therapy;Electroencephalography;experimental study;Frequencies;functional disability;Functional disorder;functional magnetic resonance imaging/electroencephalography;functional outcomes;Future;Goals;Health Care Costs;High Prevalence;Hippocampus;Hospitalization;Impaired cognition;improved;In Vitro;in vivo;indexing;Individual;ineffective therapies;information processing;insight;Intervention;Investigation;Knowledge;Learning;Legal;Literature;magnetic field;Magnetoencephalography;marijuana legalization;marijuana use;marijuana use disorder;Measurement;Measures;medication nonadherence;Memory;Mental Health;Mentors;Modeling;motivational enhancement therapy;multimodality;neural;Neurobiology;neuromechanism;Neurosciences;Noise;novel;Outcome;peer;Pharmaceutical Preparations;Population;Population Intervention;Principal Investigator;Prognosis;psychiatric symptom;Psychoses;psychosocial;psychotic symptoms;Radial;Relapse;repetitive transcranial magnetic stimulation;Research;Research Personnel;Resolution;response;Rest;risk perception;Scalp structure;Severities;Short-Term Memory;skills;social;source localization;Statistical Data Interpretation;structural imaging;Symptoms;Time;tool;Training;Trauma;treatment response;Veterans;Violence;Work

PROJECT_TITLE: A neurobiological investigation of cannabis use and misuse in Veterans


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SYDNEY

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: UNIVERSITY OF NEW SOUTH WALES

PHR: COSMIC is an international consortium of population-based prospective longitudinal cohorts examining the risk and protective factors and biomarkers for cognitive decline and dementia in older individuals world-wide. From the time of its initial funding in 2017, COSMIC has developed into a consortium of 54 studies from 39 countries in six continents, with a combined sample size of 175,199, and an additional 25 studies in negotiation, potentially increasing the sample to 300,000, with several strategic collaborations. With its global reach, open sharing of data and diverse network of researchers, COSMIC is creating a truly global epidemiology of dementia that is needed to meet the ambitious goals of the 2017 World Health Assembly to address the global epidemic of dementia, and the hopes of people at risk of dementia everywhere.

PI_NAMEs: SACHDEV, PERMINDER S (contact)

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Address;Air Pollution;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;analytic epidemiology;Asia;Asian;Australia;Biological Markers;Black race;Blood;brain health;burden of illness;career;Cerebrovascular Disorders;Cognitive;Cognitive aging;cohort;Cohort Studies;Collaborations;collaborative approach;Communities;Country;Data;Data Analyses;data harmonization;data platform;Data Pooling;data sharing;Data Storage and Retrieval;Dementia;dementia risk;Development;Diagnosis;Diagnostic;Dietary Practices;digital;disability;Disease;Economics;Environment;Epidemic;Epidemiology;Equity;ethnoracial;Evaluation;Evidence based practice;forging;frailty;Funding;Genetic;Genetic Markers;Genetic Risk;Geographic Locations;Goals;Health;Hispanic;Image;Impaired cognition;Incidence;Income;indexing;Individual;innovation;International;Investigation;Liquid substance;Loneliness;Longitudinal cohort;Longitudinal cohort study;Longitudinal Studies;low and middle-income countries;Magnetic Resonance Imaging;Maps;Measures;Mediation;Memory;Meta-Analysis;mild cognitive impairment;Minority Groups;Modality;Modeling;modifiable risk;Monitor;Morbidity - disease rate;mortality;multimodality;neuroimaging marker;novel;Older Population;Ontology;Paper;Participant;Persons;Phenotype;Plasma;polygenic risk score;Population;population based;Population Heterogeneity;Populations at Risk;Positioning Attribute;Postdoctoral Fellow;prevent;programs;prospective;protective factors;Public Health;Publishing;Research;Research Personnel;resilience;resilience factor;Resources;response;Risk;Risk Factors;Risk Reduction;Role;Sample Size;Sampling;Sleep;social;social contact;social engagement;specific biomarkers;success;Syndrome;Time;Training and Education;Underrepresented Populations;United States National Institutes of Health;vascular cognitive impairment and dementia;vascular risk factor;Vision;Washington;Work;World Health

PROJECT_TITLE: A global epidemiology of cognitive impairment and dementia due to Alzheimer's disease and related disorders: the COSMIC Collaboration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative We will evaluate the capacity of unique mosaic nanoparticles to amplify primary and memory antibody responses to the HIV envelope protein. Our results should reveal novel vaccine strategies applicable to a wide range of microbes including mutating viruses including HIV.

PI_NAMEs: ALLMAN, DAVID M (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Affinity;Antibodies;Antibody Affinity;Antibody Response;Antibody titer measurement;Antigens;B Cell Proliferation;B cell repertoire;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Cells;Clonal Expansion;Clone Cells;Complement;Complement 3d;Complement 3d Receptors;Complex;Data;design;Epitopes;Event;Excision;experience;Frequencies;Glycoproteins;glycosylation;HIV;HIV Antibodies;HIV envelope protein;Humoral Immunities;Immunization;immunogenic;immunogenicity;improved;In Vitro;in vivo;Infection;insight;Label;Ligands;Ligation;Membrane;Memory;Memory B-Lymphocyte;Microbe;mosaic;Mus;Mutate;nanoparticle;neutralizing antibody;notch protein;novel vaccines;Pathway interactions;Physiologic pulse;Plasma Cells;Play;Polysaccharides;Protocols documentation;Publishing;receptor;Receptor Activation;Receptor Signaling;response;Role;Secondary to;Serology;Serum;Specificity;stem;Testing;tool;vaccination strategy;Vaccine Design;vaccine strategy;vaccine-induced immunity;Variant;Virus;Work

PROJECT_TITLE: The Notch Pathway in Antigen Design

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Maternal Health;Rare Diseases;Sickle Cell Disease;Social Determinants of Health;Women's Health Research

ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: STRATHMORE UNIVERSITY

PHR: PROJECT NARRATIVE Optimizing blood transfusion services in LMICs represents both a major health challenge and a social imperative; postpartum hemorrhage, malarial anemia, sickle cell disease, and all other forms of acute hemorrhage claim millions of lives each year across the world. We have assembled an international, multidisciplinary team to explore gaps and identify solutions across the blood continuum in a diverse set of sociopolitical contexts within Kenya's current health setting. We seek to implement supply chain solutions and innovative-disruptive techniques aimed at ensuring sustainability and generalizable to similar contexts within the Sub-Saharan subcontinent.

PI_NAMEs: KIVULI, TECLA CHELAGAT (contact);KUMAR, PRATAP ;PUYANA, JUAN CARLOS

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: 3-Dimensional;Acute;Address;Administrator;Affect;Africa South of the Sahara;Attitude;Blood;Blood Banks;Blood Donations;Blood Transfusion;Caring;Clinical;Clinical Pathways;Collection;Communities;Complex;Consensus;Country;County;Critical Care;crowdsourcing;design;Development;Discipline of obstetrics;Engineering;Ensure;evidence base;experience;Failure;Goals;Health;Healthcare Systems;Hemorrhage;Hospitals;Income;Industrialization;innovation;International;Intervention;Kenya;Literature;Location;low and middle-income countries;malarial anemia;Maternal Mortality;meetings;mobile computing;multidisciplinary;Pathway interactions;Patients;Phase;Policy Maker;Politics;Postpartum Hemorrhage;Process;programs;Public Health;Research;Resource-limited setting;Rural;rural setting;Safety;Series;Services;Sickle Cell Anemia;social;social media;socioeconomics;Structure;supply chain;System;Techniques;Technology;technology validation;Testing;therapy design;Time;Transfusion;trauma care;Universities;urban setting;Work

PROJECT_TITLE: Pathways for innovation in Blood Transfusión Systems in Kenya (PITS Kenya)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: BOISE

ORG_DEPT: BIOLOGY

ORG_NAME: BOISE STATE UNIVERSITY

ORG_STATE: ID

PHR: PROJECT NARRATIVE The T34 Bridges to the Baccalaureate proposal is designed as a continuation of the Southwest Idaho Bridges to Baccalaureate (SWID B2B) Program, an enduring undergraduate research program in Idaho currently funded by the NIH R25 mechanism. The SWID B2B program supports both the transition of underrepresented (UR) students from College of Western Idaho community college into biomedical degree programs at Boise State University and their successful graduation. This B2B program has established the long-term goal of increasing the number of individuals from underrepresented groups in Idaho that pursue research careers in the biomedical sciences. The short-term goals of this B2B program are to i) increase the number of UR students who transfer to BSU into biomedical science majors, ii) increase retention and the number of UR students that graduate from BSU, and iii) prepare UR students for careers in the biomedical sciences. This program will include annual cohorts of 10 UR students and will also benefit many others through enhanced courses and information regarding the biomedical research career landscape.

PI_NAMEs: JORCYK, CHERYL LYNN (contact);LYSNE, STEVEN ;PAQUETTE, HOLLY K;ROHN, TROY T

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Biomedical Research;bridge to the baccalaureate;career;cohort;college;community college;course development;Data;Degree program;Enrollment;experience;faculty mentor;Fellowship;Funding;Funding Mechanisms;Future;Goals;Graduation Rates;Idaho;improved;Individual;Institution;interest;Mentors;Mentorship;Participant;peer coaching;programs;recruit;Research;retention rate;Science;Self Assessment;statistics;student participation;Students;success;transfer student;undergraduate research experience;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;university student

PROJECT_TITLE: Southwest Idaho Bridges to Baccalaureate Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRRATVE We lack a deep understanding of the interplay between alcohol use and brain function within individuals. The goal of this proposal is to examine this interplay in adolescents and young adults, both in the long-term (years) and in the short-term (days/weeks). This may lead to an improved understanding of the origins of alcohol use disorder (AUD), and ultimately may inform the development of novel treatments and preventative measures for AUD and problematic alcohol use more broadly.

PI_NAMEs: BARANGER, DAVID A (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: Acceleration;addiction;Address;Adolescence;Adolescent and Young Adult;Age;age related;Alcohol abuse;Alcohol consumption;alcohol involvement;alcohol use disorder;alcohol use initiation;Alcohols;Behavior;Behavioral;binge drinking;Brain;brain behavior;career;career development;career networking;Characteristics;cognitive control;Collection;college drinking;Dangerousness;Data;Data Analyses;Data Collection;Data Set;Decision Making;design;Development;drinking;drinking behavior;Education;Esthesia;Etiology;executive function;experimental study;financial incentive;Future;global health;Goals;Heavy Drinking;Image;improved;Individual;Individual Differences;innovation;insight;Knowledge;Lead;Leadership;Link;Machine Learning;Maintenance;Maps;Measurement;Measures;Mentorship;Methodology;neural;Neurobiology;Neurocognitive;neuroimaging;neuroregulation;novel;Pattern;Policies;Prevention;Preventive measure;Process;programs;prospective;Publications;regional difference;Research;Research Personnel;resilience;Resolution;reward processing;Rewards;Risk Taking;Sampling;Scanning;Signal Transduction;skills;Techniques;Testing;theories;Training;underage drinking;university student;Variant;young adult;young adult alcohol use

PROJECT_TITLE: Reciprocal longitudinal associations between brain function and alcohol use trajectories in adolescents and young adults

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: Dementia is a global epidemic of our aging population. Veterans face unique risk factors for dementia of vascular subtype and Alzheimer’s disease as a result of aging, primary and secondary metabolic disease, in addition to service-related toxic exposures, post-traumatic stress, and military-related injuries such as traumatic brain injury. In 2017, forty nine percent of veterans were estimated to be 65 or older, in comparison to only fifteen percent of the general population. We propose to undertake cutting-edge biomarker work, including cell-specific exosome-based molecular quantifications, brain and retinal imaging, and advanced data analytics to investigate therapeutically relevant pathologies in VCID. This work will contribute to development of more accurate diagnostic biomarkers with great value for pursuit of consorted efforts toward novel therapeutic developments of the devastating epidemic of VCID and Alzheimer’s disease.

PI_NAMEs: ELAHI, FANNY M (contact)

PROJECT_TERMS: accurate diagnostics;Acute;Affect;Aging;aging population;Alzheimer's Disease;angiogenesis;Area;Artificial Intelligence;Astrocytes;Autoimmune;Autoimmune Diseases;Behavior;Big Data;Biological;Biological Markers;biomarker development;biomarker discovery;biomarker identification;biomedical informatics;Blood;Blood Vessels;Brain;Brain imaging;career;Cells;cerebrovascular biology;Chronic;Clinic;Clinical;clinical biomarkers;Clinical Data;clinical phenotype;clinical training;Cognition;Cognitive;cognitive testing;cohort;Collaborations;Data;Data Analytics;Data Collection;Data Science;Degenerative Disorder;Dementia;dementia risk;Development;Diagnostic;diagnostic biomarker;Disease;Disease Progression;disorder subtype;Dissection;drug development;Early Diagnosis;Emotional;endophenotype;Endothelium;Enrollment;Ensure;Epidemic;Epidemiology;Etiology;exosome;experience;Face;Failure;Fibrosis;Functional disorder;Funding;General Population;Goals;Homeostasis;Human Characteristics;human disease;human old age (65+);hypoperfusion;Image;Impaired cognition;Impairment;improved;Individual;Inflammation;Inflammatory;Injury;Intervention;Knowledge;Leadership;Machine Learning;Mediating;Mediation;medical specialties;Medicine;Mental Health;Mentors;Mentorship;Metabolic Diseases;Methods;Microvascular Dysfunction;Military Personnel;military veteran;Modality;Modeling;Molecular;Molecular Biology;molecular marker;multidimensional data;multimodal data;National Institute of Neurological Disorders and Stroke;Natural regeneration;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;neuroimaging;neuroinflammation;Neurology;Neurons;Neurosciences;neurovascular;novel;novel strategies;novel therapeutics;Outcome;Pathogenicity;Pathologic Neovascularization;Pathology;Pathway interactions;Patients;Pattern;Perfusion;Phase;Phenotype;phenotypic biomarker;Physicians;Play;post-traumatic stress;precision medicine;predictive signature;programs;prospective;Prospective Studies;Proteomics;proteostasis loss;radiological imaging;Research;Research Personnel;resilience;retinal imaging;Risk;Role;Scientific Advances and Accomplishments;Scientist;Services;Site;skills;Stroke;success;Synapses;System;tau Proteins;tau-1;Technical Expertise;Techniques;Technology;Testing;Therapeutic;therapeutic development;Time;tool;Toxicant exposure;Training;Traumatic Brain Injury;unsupervised learning;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;Vascular Dementia;Vascular Diseases;Veterans;Vulnerable Populations;Work

PROJECT_TITLE: A Precision Medicine Approach To Study Targetable Pathways in Vascular Dementia


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: PROJECT NARRATIVE  Approximately 45,500 Veterans receive hemodialysis and an additional 14,000 American Veterans with chronic kidney disease initiate dialysis each year. Cardiovascular disease is the leading cause of death in Veterans on dialysis and the risk of death is particularly high on the day of dialysis. The mechanisms that contribute to the high risk of cardiovascular collapse and death during dialysis are poorly understood and treatment strategies for this condition are limited. The candidate's research goal is to evaluate novel mechanisms by which dialysis-driven risk factors may contribute to a distinct form of severe cardiovascular disease in chronic kidney disease patients. This work is especially relevant in Veterans who have disproportionately high kidney disease prevalence and cardiovascular disease. This proposal will improve healthcare of Veterans because we will generate key foundational data to explain cardiovascular collapse during dialysis and importantly provide the basis for new treatments to reduce cardiovascular morbidity and mortality in this population. .

PI_NAMEs: SHARMA, SHILPA  (contact)

PROJECT_TERMS: Acute;Address;Affect;Affinity;American;Applications Grants;Area;Award;Biological Markers;Biometry;Blood;Bone Diseases;Brain Hypoxia-Ischemia;cardiovascular collapse;Cardiovascular Diseases;cardiovascular imaging;Cardiovascular system;career;career development;Cause of Death;Cell membrane;Cellular biology;Cessation of life;Chronic Kidney Failure;Clinical;clinical investigation;Clinical Trials;Critical Illness;Data;Data Analyses;design;Development;Dialysis patients;Dialysis procedure;diphosphoglycerate;Disease Progression;Echocardiography;Educational workshop;End stage renal failure;Erythrocytes;Event;Excess Mortality;experimental study;extracellular;Formulation;Funding;Future;General Population;Goals;health goals;Healthcare;Heart;heart imaging;Hemodialysis;hemodynamics;Hemoglobin;high risk;high risk population;Hypotension;Hypotensives;Hypoxia;Image;Image Analysis;Imaging Techniques;improved;improved outcome;In Vitro;in vitro Model;inorganic phosphate;Institution;Iron;Kidney;Kidney Diseases;Laboratories;Laboratory Research;Lead;Link;Los Angeles;Magnetic Resonance;Maintenance;Manuscripts;Measures;Mentors;Mentorship;Metabolism;Methodology;Minerals;Morbidity - disease rate;mortality;mortality risk;Myocardial;Myocardial dysfunction;Myocardial Ischemia;Myocardial tissue;novel;novel therapeutic intervention;Observational Study;Outcome;Outpatients;Oxygen;Pathogenesis;patient population;Patients;Phosphorus;Physicians;Physiology;Play;Population;Preparation;Prevalence;Productivity;programs;Prospective Studies;quantitative imaging;Records;Renal Replacement Therapy;Research;Research Personnel;Resources;Risk;Risk Factors;Scientist;Serum;skills;Techniques;Temperature;Time;Tissues;Training;translational study;Translations;treatment strategy;ultrasound;Universities;Veterans;Work

PROJECT_TITLE: Dynamic Changes in Erythrocyte 2,3 DPG as a Driver of Cardiac Dysfunction in End Stage Kidney Disease


ORG_NAME: BALTIMORE VA MEDICAL CENTER

PHR: Traumatic brain injury (TBI) results in cellular structural damage followed by widespread dysfunctions including neuroinflammation with secondary neurotoxicity and ultimately neurological deficits. We aim to characterize the therapeutic effects of interventions that modulate progressive brain neuroinflammation, neurodegeneration, and associated chronic neurological impairments after TBI. Veterans are a distinct group of brain trauma patients because military TBI features specific conditions that impact the developing neuropathology. Recent studies have shown that caloric restriction, and select dietary interventions results in significant attenuation of pro- inflammatory systemic and central (brain) mechanisms. These processes may underpin the activation of neurorestorative pathways and facilitation of neurological recovery. We hypothesize that exposure to caloric restriction and related mechanisms may change the trajectory of neuroinflammation and neurodegeneration progression in TBI; accelerating and extending the endogenous repair systems and promotingrehabilitation.

PI_NAMEs: STOICA, BOGDAN ADRIAN (contact)

PROJECT_TERMS: Acceleration;Address;Affective;Antiinflammatory Effect;Attenuated;attenuation;axonal degeneration;Brain;brain metabolism;Caloric Restriction;cell type;Cells;Chronic;Chronic Phase;Cognition Disorders;Cognitive;cognitive function;Complex;design;Development;dietary;Dietary Intervention;Disease;effective intervention;Esters;excitotoxicity;Exposure to;Flow Cytometry;Fostering;Functional disorder;glial activation;Goals;gray matter;Immune;Impaired cognition;Impairment;improved;Inflammation;Inflammatory;Injury;Intermittent fasting;intervention effect;Ketones;Lead;Lesion;Mediating;Memory;Microglia;Military Personnel;Modeling;Molecular;Mood Disorders;Motor;motor disorder;Mus;nano-string;Nerve Degeneration;nerve stem cell;Nervous System Physiology;neurobehavioral;Neurodegenerative Disorders;neurogenesis;neuroinflammation;Neurologic;Neurologic Deficit;neurological recovery;neurological rehabilitation;neuron loss;Neuronal Plasticity;Neurons;neuropathology;neuroprotection;neurorestoration;neurotoxic;neurotoxicity;nicotinamide-beta-riboside;Nonpharmacologic Therapy;novel;Oral;Oral Administration;organ injury;Oxidative Stress;Pathway interactions;Patients;Peripheral;Phenotype;Prevention;Process;Production;progressive neurodegeneration;Recovery of Function;Rehabilitation therapy;repaired;response;response to injury;restoration;Role;Sepsis;single nucleus RNA-sequencing;Sleep Disorders;sustained recovery;Synaptic plasticity;System;systemic inflammatory response;Testing;Therapeutic Effect;Therapeutic Intervention;therapeutically effective;Time;Tissues;transcriptomics;Trauma;Trauma patient;Traumatic Brain Injury;Traumatic Brain Injury recovery;traumatic event;United States Department of Veterans Affairs;Veterans;white matter

PROJECT_TITLE: Caloric restriction promotes sustained neurological recovery after TBI

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE: Toxoplasma is an important opportunistic pathogen of humans and has infected over a billion people worldwide, where it can cause severe disease in HIV/AIDS patients, the developing fetus and other susceptible children and adults. Our goal is to use comparative approaches to determine how this parasite causes disease.

PI_NAMEs: BOYLE, JON P (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Acute;Adopted;Adult;Animal Model;Animals;Antiparasitic Agents;Automobile Driving;Biology;Candidate Disease Gene;Cell Aging;Cell Cycle;Cells;Child;comparative;comparative genomics;Complement;Cyst;Data;Development;Developmental Gene;Disease;DNA Damage;epigenomics;experience;experimental study;Fetal Development;follow-up;Foundations;functional genomics;Funding;Gene Expression Regulation;Genes;Genetic;genetic approach;Goals;Growth;Growth and Development function;HIV/AIDS;Host Defense;human disease;human pathogen;Immune response;Immunosuppression;in vitro Assay;Infection;Inflammatory;Inflammatory Response;Innate Immune Response;innovation;knockout gene;Life Cycle Stages;Link;Masks;Modeling;Molecular;new therapeutic target;novel;novel therapeutic intervention;nucleic acid binding protein;obligate intracellular parasite;opportunistic pathogen;Organism;Outcome;Parasites;Pathogenesis;Pathway interactions;Patients;Persons;Phenotype;Placenta;Predisposition;prevent;Refractory;Regulation;Regulatory Pathway;response;Signal Pathway;Sporozoites;Stress;success;Synteny;System;Testing;Therapeutic Intervention;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;trait;transcriptome sequencing;transcriptomics;Transgenic Organisms;Virulence;Virulence Factors;virulence gene;Work

PROJECT_TITLE: Comparative and functional genomics of Toxoplasma and Hammondia hammondi

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Lung;Lung Cancer;Prevention

ORG_CITY: LYON

ORG_COUNTRY: FRANCE

ORG_FIPS: FR

ORG_NAME: INTERNATIONAL AGENCY FOR RES ON CANCER

PHR: Narrative: The Lung EArly Proteins (LEAP) Project Lung cancer screening can reduce the risk of lung cancer mortality, but better tools are needed to target participants who will benefit and to avoid harms in people undergoing screening. We have recently developed a test that measures proteins in blood to predict development of lung cancer. Our project will test whether this panel is useful in two specific settings: (1) to decide who should undergo lung cancer screening by observing how protein measurements change within the same person over time, and (2) to decide whether to perform a biopsy on high-risk nodules identified during screening.

PI_NAMEs: ROBBINS, HILARY A. (contact)

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: Address;All-Trans-Retinol;American College of Radiology;Benign;Biological Assay;Biological Markers;Biopsy;Blood;Blood specimen;Cancer Etiology;cancer risk;Carotene;case control;Cessation of life;Classification;Clinical;clinical predictors;Decision Aid;Decision Making;design;Detection;Development;Diagnosis;Diagnostic;Diagnostic Procedure;early detection biomarkers;Early identification;efficacy trial;Ensure;Equilibrium;follow-up;former smoker;Future;Harm Reduction;high risk;high risk population;Histologic;improved;innovation;Intervention;low dose computed tomography;Lung;lung cancer screening;lung development;Lung nodule;Malignant - descriptor;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Measures;Mission;model development;Modeling;mortality;Nodule;novel;Participant;Patients;Persons;predictive modeling;predictive tools;Primary Care;prospective;Prospective, cohort study;protein biomarkers;Proteins;Risk;risk prediction;Risk Reduction;Sampling;Scanning;Scheme;screening;Screening for Ovarian Cancer;screening program;Smoking;Technology;Testing;Time;tool;Translating;translational study;tv watching;Validation

PROJECT_TITLE: The Lung EArly Proteins project: A LEAP toward implementing biomarkers in lung cancer screening

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Neurosciences;Pain Research;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Project Narrative Adolescent alcohol use leads to long-term neural and behavioral changes, and it is known that chronic alcohol exposure in adults increases pain. The current proposal will test the effect of chronic alcohol exposure during adolescence on long-term pain outcomes and will work to identify the neurobiological mechanisms underlying those effects. Our proposal uses behavioral pharmacology, slice electrophysiology, epigenetic analysis, and circuit-based approaches to test the role of specific amygdala peptide systems in mediating heightened pain in individuals with a history of adolescent alcohol exposure.

PI_NAMEs: GILPIN, NICHOLAS WARREN (contact);WILLS, TIFFANY A

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Acute;Address;Adolescence;Adolescent;adolescent alcohol effect;adolescent alcohol exposure;Adult;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol testing;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholic Intoxication;Alcohols;Amygdaloid structure;Analgesics;Animals;antagonist;antinociception;anxiety-like behavior;Behavior;Behavioral;behavioral pharmacology;Brain;Carrageenan;cell type;Cells;Child;Child Abuse;Chronic;chronic alcohol ingestion;chronic pain;Collaborations;Corticotropin-Releasing Hormone;CRISPR/Cas technology;Data;Development;Dose;Electrophysiology (science);Epigenetic Process;Equilibrium;Ethanol;Exhibits;experimental study;Female;Frequencies;Genetic;Goals;Human;Hyperalgesia;Individual;inflammatory pain;Lead;Life;Literature;Long-Term Effects;male;Measures;Mechanics;Medial;Mediating;men;midbrain central gray substance;Midbrain structure;Modeling;Molecular;neural;neuroadaptation;neurobiological mechanism;Neurobiology;Neurons;Nicotine Withdrawal;Nociception;nociceptive response;Nociceptors;optogenetics;Organism;Outcome;Output;Pain;pain outcome;pain reduction;pediatric trauma;Peptides;pharmacologic;Phenotype;Process;Rattus;receptor;Receptor Cell;Receptor Gene;Receptor Signaling;Recording of previous events;Reporting;Research;response;Risk;Risk Taking;Role;Severities;Sex Differences;Sleep disturbances;Slice;Synapses;Synaptic Transmission;System;Testing;traumatic stress;underage drinking;Validation;vapor;Virus;Wistar Rats;Woman;Work

PROJECT_TITLE: 8/8 NADIA U01 Long-Term Effects of Adolescent Alcohol on Pain


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Cardiovascular

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Diagnosis of the initial presentation of aortic dissection (AD), a devastating cardiovascular disease known for its rapid propagation and high morbidity and mortality, is a challenge because the symptoms are similar to those of many other health problems. The goal of this proposed research is to advance our understanding of the important role of tissue mechanical properties and microstructures of the arterial wall in the initiation and progression of AD. The knowledge we gain from this research is expected to provide insights into biomechanical markers useful for identifying the origin and propensity of AD with direct clinical impact on the developments of new early diagnostics and interventions.

PI_NAMEs: ZHANG, YANHANG KATHERINE (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;Affect;Age;Anatomy;Aneurysm;Annual Reports;Aorta;Aortic Rupture;Arteries;Biomechanics;Cardiovascular Diseases;Cause of Death;Cessation of life;Clinical;Collagen;Computer Models;Death Rate;density;Dependence;Development;Diagnosis;Diagnostic;Dissection;Elastic Fiber;Elasticity;elastography;Elements;Event;Extracellular Matrix;Fiber;General Population;Goals;Health;Hospitals;Hour;Human;Image;Incidence;Injury;insight;Intervention;Knowledge;Length;Location;Maps;Measurement;mechanical behavior;mechanical load;mechanical properties;Mechanics;millimeter;Modeling;Morbidity - disease rate;mortality;multiphoton imaging;Nature;Optics;Patients;Persons;Physiological;Process;Property;Research;Resolution;Role;Site;Structure;Symptoms;Testing;Thoracic aorta;Tissues;Validation;Vascular remodeling

PROJECT_TITLE: Multi-Scale Integration of Extracellular Matrix Mechanics in Vascular Remodeling

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Evidence-based VA care is best for meeting Veterans’ mental health needs, such as depression, PTSD and opioid use disorder, to prevent suicide or overdose. But some key evidence-based practices only reach 3- 28% of patients. Participatory system dynamics (PSD) helps improve quality with existing resources, critical in mental health and all VA health care. PSD uses learning simulations to improve staff decisions, showing how goals for quality can best be achieved given local resources and constraints. We aim to significantly increase the proportion of patients who start and complete evidence-based care, and determine the costs of using PSD for improvement. Empowering frontline staff with PSD simulation encourages safe ‘virtual’ prototyping of complex changes to scheduling, referrals and staffing, before translating changes to the ‘real world.’ This study determines if PSD increases Veteran access to the highest quality care, and if PSD better maximizes VA resources when compared against usual trial-and-error approaches to improving quality.

PI_NAMEs: ZIMMERMAN, LINDSEY EILEEN (contact)

PROJECT_TERMS: addiction;Adopted;Adoption;Area;arm;Behavior;budget impact;Budgets;burnout;Businesses;Caring;Chronic;Clinic;Cluster randomized trial;Complex;Computer Assisted;cost;Cost Analysis;Data;data resource;data warehouse;Discipline;Dose;dynamic system;E-learning;effective therapy;Effectiveness;empowerment;Engineering;Equilibrium;evidence base;Evidence based practice;Frontline worker;General Practitioners;Goals;Guidelines;Health Personnel;Health Services;Health Services Administration;Health system;Healthcare;Healthcare Systems;high risk;Hour;Impairment;implementation research;implementation science;improved;Infrastructure;innovation;Investments;Laws;Learning;learning engagement;learning strategy;Measures;Mediating;Mediation;Mediator;medical specialties;meetings;Mental Depression;Mental Health;Mental Health Services;Methodology;Methods;Modeling;multidisciplinary;Notification;online resource;opioid use disorder;Outpatients;Overdose;Participant;patient population;Patients;Pattern;Pharmacotherapy;Post-Traumatic Stress Disorders;Probability;programs;prototype;Provider;Psychotherapy;Quality of Care;Randomized;referral services;Research;Resources;Schedule;Science;simulation;Source;Statistical Computing;Suicide prevention;Surveys;synergism;System;Systems Theory;Testing;Theoretical Studies;Theory of Change;Time;Training;Translating;treatment as usual;United States Health Resources Administration;Veterans;Veterans Health Administration;virtual;Weight

PROJECT_TITLE: Participatory system dynamics vs usual quality improvement: Is staff use of simulation an effective, scalable and affordable way to improve timely Veteran access to high-quality mental health care?

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Adverse events during care transitions are frequent, can lead to readmissions, and represent an ongoing threat to patient safety. To address this problem, we will combine, adapt, and extend interoperable digital health tools that leverage patient-reported outcomes and electronic health record data to engage patients with multiple chronic conditions in understanding their individualized risks and reporting global health symptoms during transitions. We will assess the effect of this intervention on rates of adverse events during care transitions in a randomized controlled trial, and evaluate the feasibility of implementation and use for similar institutions with different electronic health records.

PI_NAMEs: DALAL, ANUJ K (contact)

PROGRAM_OFFICER_NAME: CHANEY, KEVIN

PROJECT_TITLE: Real-time symptom monitoring using ePROs to prevent adverse events during care transitions

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ORG_CITY: POMONA

ORG_NAME: WESTERN UNIVERSITY OF HEALTH SCIENCES

PHR: Project Narrative Pharmacological modulation of mechanosensitive Piezo ion channels could help treat numerous diseases such as inflammation, pain, and hypertension. To expand the currently limited Piezo channel pharmacome, this proposal will investigate structural mechanisms of Piezo1 activation by a small molecule agonist and leverage a recently identified pharmacological binding site to rationally design novel modulators with improved properties. Successful completion of this project will deepen our fundamental understanding of vertebrate mechanosensation and uncover novel molecules with potential value for basic research and the clinic.

PI_NAMEs: LACROIX, JEROME JACQUES (contact);LUO, YUN

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Acceleration;Affinity;Agonist;analog;Arthrogryposis;base;Basic Science;Binding;Binding Sites;Biological;Biological Assay;bone repair;Calcium;Cartilage injury;Chemicals;Clinic;Clinical;Complex;Computing Methodologies;Degenerative polyarthritis;design;Disease;Docking;Dose;drug candidate;Electrophysiology (science);Elements;Erythrocytes;Eukaryotic Cell;Extracellular Domain;Free Energy;Homologous Gene;Human;Hydrophobicity;Hypertension;Image;improved;Infection prevention;Inflammation;inhibitor;innovation;interdisciplinary approach;Ion Channel;Lead;Libraries;Ligand Binding;lymphatic vessel;Lymphedema;Machine Learning;Malaria;Maps;Measurement;mechanical force;Mechanics;mechanotransduction;Membrane Proteins;Methods;Modeling;Molecular;Molecular Conformation;molecular dynamics;Muscle Cells;Mutagenesis;Natural regeneration;novel;Outcome;Pain;Pancreatitis;pathogen;Pathway Analysis;Pathway interactions;Peer Review;pharmacologic;pharmacophore;Physical Exercise;Physical Performance;Physiological;Piezo 1 ion channel;Piezo 2 ion channel;Piezo ion channels;Play;prevent;Printing;Property;Pruritus;Publishing;Rapid screening;rational design;Research;Resolution;response;reverse genetics;Role;scaffold;screening;small molecule;Stimulus;Structure;Structure-Activity Relationship;System;Testing;Time;Transmembrane Domain;tumor growth;tumor progression;Vertebrates;virtual;virtual screening;Writing

PROJECT_TITLE: PHARMACOLOGICAL MODULATION OF PIEZO1 CHANNELS

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Natural Products;Sepsis

ORG_CITY: MINNEAPOLIS

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Sepsis is the leading cause of hospital death, with particularly poor prognosis in aging individuals. Targeted clearance of chronically accumulated pro-inflammatory senescent cells with senolytics represents a promising approach to prevent the progression of sepsis prior to entrenched inflammation. This proposal will determine drug target engagement, dosing, and both biologic and preliminary clinical efficacy of fisetin in aging individuals with acute infections.

PI_NAMEs: PUSKARICH, MICHAEL A. (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Acute;acute infection;adverse outcome;Affect;Aging;aging process;aging related;animal old age;Anti-Inflammatory Agents;Antibiotics;Apoptosis;Biological;Biological Markers;Blinded;Bolus Infusion;Cardiovascular system;CD3 Antigens;CDKN2A gene;Cell Aging;Cells;Cessation of life;Characteristics;Chronic;Clinical;clinical application;clinical efficacy;Clinical Trials;clinically relevant;cytokine;cytokine release syndrome;Data;Dose;Drug Targeting;endothelial dysfunction;Enrollment;Exhibits;Fire - disasters;fisetin;Flavonoids;Functional disorder;Genes;Geroscience;Goals;Health Care Costs;hospital care;Hospital Mortality;Hospitalization;Hospitals;Human;human tissue;Immune;Immune response;In Vitro;Individual;Infection;Inflammation;Inflammatory;inflammatory modulation;Intensive Care Units;Interruption;Intervention;Investments;Kidney;kidney dysfunction;Lung;Lymphocyte;MAP Kinase Gene;Measures;Mechanical ventilation;Mediating;Mediator;Messenger RNA;Molecular;mortality;mortality risk;multidisciplinary;Multiple Organ Failure;National Institute on Aging;Natural Products;NF-kappa B;novel;older patient;Oral;Organ;Organ failure;Outcome;participant enrollment;pathogen;Pathway interactions;Patient Admission;Patients;Pattern;Peripheral;Pharmaceutical Preparations;Phase II Clinical Trials;phase II trial;phase III trial;Placebo Control;Placebos;Plasma;pre-clinical;Pre-Clinical Model;Predisposition;prevent;Probability;Prognosis;Randomized;Randomized, Controlled Trials;Regimen;Research;Resistance;respiratory;response;Rodent;Role;Running;Sampling;Science;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Sepsis;Severities;side effect;Stimulus;success;Syndrome;systemic inflammatory response;Testing;Therapeutic;treatment effect;Vasoconstrictor Agents

PROJECT_TITLE: Senolytics To slOw Progression of Sepsis (STOP-Sepsis) trial


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Mental Health;Neurodegenerative;Neurosciences;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE Chronic psychosocial stress is a major risk factor that contributes to the vascular contributions to cognitive impairment and dementia. The purpose of this project is to determine the mechanisms by which chronic stress contributed to cerebrovascular dysfunction and cognitive decline, and the relationship with Alzheimer’s disease, with a focus on the mechanistic role of xanthine oxidase.

PI_NAMEs: CHANTLER, PAUL D (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: 3xTg-AD mouse;Acceleration;acid stress;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid beta-Protein;Autopsy;Blood;Blood Vessels;Brain;brain tissue;cerebrovascular;Cerebrovascular Disorders;cerebrovascular pathology;Chronic;Chronic stress;Circulation;Clinical;clinical predictors;Cognition;Cognitive;cognitive function;comorbidity;conditional knockout;Data;Dementia;Dependovirus;Development;Disease;drinking water;Drug Targeting;endothelial dysfunction;Endothelium;Etiology;Event;experimental study;febuxostat;Foundations;Functional disorder;Future;Generations;Goals;Health;Hepatic;Hepatocyte;Hydrogen Peroxide;Impaired cognition;Impairment;improved;Inflammation;Inflammatory;inhibitor;Knock-out;Knockout Mice;Link;Liver;Mediating;Modeling;Molecular;mouse toll-like receptor 4;Mus;neuroinflammation;Nitric Oxide;Nitrites;Nitrogen Dioxide;novel;Outcome;overexpression;Oxidants;Oxidative Stress;oxidoreductase inhibitor;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Physiological;Plasma;prevent;Process;Protocols documentation;Psychosocial Stress;receptor;receptor expression;Receptor Signaling;Research;Research Design;Risk Factors;Role;Signal Pathway;Site;Source;Stress;Superoxides;synergism;tau Proteins;Testing;Tissues;tool;United States National Institutes of Health;Uric Acid;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;vascular contributions;Vascular Dementia;Vascular Diseases;vascular inflammation;Work;Xanthine Oxidase;XDH gene

PROJECT_TITLE: Psychosocial Stress-Induced Vascular Contributions To Cognitive Impairment And Alzheimer's Disease: The Role of Xanthine Oxidase

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative Training devoted to understanding molecular and cellular mechanisms of cancer is vital to the development of novel treatments and therapies for patients.

PI_NAMEs: CRAMER, SCOTT D;JORDAN, CRAIG T. (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Cancer Biology;Training Programs

PROJECT_TITLE: Training Program in Cancer Biology


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Kidney Disease;Patient Safety;Prevention

PHR: PROJECT NARRATIVE Cardiac surgery is effective for improving the health of patients with cardiovascular disease, but many patients experience complications such as acute kidney injury (AKI) that result in an increased risk of death after surgery. Maintaining normal pulsatile blood flow with the heart lung machine during cardiac surgery may prevent AKI after cardiac surgery even though increased mechanical pulsatility damages red blood cells. This trial will identify to best level of pulsatility during cardiac surgery for minimizing red blood cell damage while preventing AKI.

PI_NAMEs: CLENDENEN, NATHAN  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Arginine;Benefits and Risks;Biology;biomedical referral center;Biometry;Blood flow;Blood Vessels;Cardiac;Cardiac Surgery procedures;Cardiopulmonary Bypass;Cardiovascular Diseases;career development;cell injury;Clinical;clinical implementation;clinical practice;Clinical Trials;Clinical Trials Design;Clinical Trials Network;cohort;Colorado;Control Groups;Critical Illness;Data;Dedications;design;Development;Development Plans;efficacy evaluation;Emergency Medicine;Endothelial Cells;endothelial dysfunction;Endothelium;Enrollment;Environment;Erythrocytes;experience;Funding;Future;Glycocalyx;Goals;Health;Heart and Lung machine;hemodynamics;Hemolysis;Hour;Impairment;improved;improved outcome;Incidence;Injury to Kidney;innovation;Intervention;Intra-Aortic Balloon Pumping;Kidney;Kidney Diseases;Lactate Dehydrogenase;Measures;Mechanics;Medical center;Mentors;Mentorship;Metabolic Pathway;metabolomics;Methodology;Microscopy;Monitor;Morbidity - disease rate;mortality;mortality risk;Nitric Oxide;Operative Surgical Procedures;Organ;organ injury;Outcome;Participant;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;Perfusion;Persons;Phase;phase III trial;Physicians;Plasma;Postoperative Period;preservation;prevent;Procedures;prospective;Pulsatile Flow;Qualifying;Randomized, Controlled Trials;Research;Resources;response;Risk;risk minimization;Risk Reduction;risk/benefit ratio;Role;single-cell RNA sequencing;Stress;Structure;Testing;Thick;Thinness;TIMP2 gene;Training;transcriptomics;trial comparing;United States;Universities;urinary;ventricular assist device;Work

PROJECT_TITLE: Optimizing pulsatility during cardiopulmonary bypass to reduce acute kidney injury

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: Princeton

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Intact dopaminergic signaling by projection neurons of the ventral tegmental area (VTADA) is required for shifting behavioral strategies in both humans and animal models. However, due to its anatomical location deep within the brain, the endogenous activity patterns of VTADA neurons have not been studied during complex behaviors requiring this form of behavioral flexibility. Using state-of-the-art deep-brain imaging techniques in conjunction with behavioral tasks in virtual reality that involve an extradimensional rule shift as well as targeted manipulation of reward expectancy, we will explore the hypothesis that task feature-specific reward prediction error signaling by VTADA underlies the vital role of DA in behavioral flexibility.

PI_NAMEs: SINISCALCHI, MICHAEL JAMES (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TITLE: Task Representations in Ventral Tegmental Area Dopamine Neurons across Shifts in Behavioral Strategy and Reward Expectation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: CORAL GABLES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This project will provide genotyping array and whole genome sequence data on an additional ~16,000 individuals and genotyping only data on ~7,650 individuals to continue to increase the ancestral diversity of the sample sets that are part of the Alzheimer's Disease Sequencing Project (ADSP). This will add to this invaluable resource for the Alzheimer's disease (AD) research community to enhance efforts to discover targets tor AD diagnosis, prevention, and treatment that apply to individuals of all ancestral backgrounds.

PI_NAMEs: DALGARD, CLIFTON L;GRISWOLD, ANTHONY JOHN;KUNKLE, BRIAN WILLIAM;PERICAK-VANCE, MARGARET A. (contact);VARDARAJAN, BADRI N

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: adjudication;African ancestry;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-42;Applications Grants;Asian;Asian ancestry;Asian population;Aspirin;Autopsy;Biological Markers;Blood;Brain;brain tissue;Brazil;cell repository;Clinic;Clinical Data;clinical diagnosis;clinical phenotype;cohort;Cohort Studies;Collaborations;Communities;Data;Data Set;diverse data;DNA;Elderly;ethnic diversity;European ancestry;Event;exome sequencing;Follow-Up Studies;Foundations;Funding;Genetic;genetic risk factor;genome sequencing;genome-wide;Genotype;Goals;Health and Retirement Study;Hispanic;Hispanic Populations;Individual;Latino;Latino Population;New York;novel;PDAP2 Gene;Phase;Phenotype;phenotypic data;Phosphorylation;Plasma;Population Heterogeneity;Prevention;Process;Production;public database;Quality Control;Research;Research Personnel;Resources;Sampling;screening;SNP array;Spanish;Statistical Study;System;tau Proteins;Testing;Underserved Population;Universities;Variant;Washington;whole genome

PROJECT_TITLE: Additional Sequencing for the Alzheimer Disease Sequencing Project (ADSP) the Follow-Up Study (FUS), The Diverse Population Initiative


NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE In all cells, mRNA is translated into protein by ribosomes, which are made in a process called ribosome biogenesis. The aim of the proposed research is to determine the role of the mitochondrial protein sulfite oxidase, or SUOX, in human ribosome biogenesis. Variants of SUOX cause the severe disease Isolated Sulfite Oxidase Deficiency (ISOD); the research proposed will advance knowledge of ribosome biogenesis regulation and determine the role of ribosome biogenesis in ISOD, contributing to understanding its pathogenesis and treatment.

PI_NAMEs: SUTTON, EMILY CATHERINE (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Antibodies;Auxins;Biogenesis;Biological Assay;Birth;Breast Epithelial Cells;Cell Nucleolus;Cell Nucleus;Cell Physiology;Cells;Child;Clinical;clinically relevant;craniofacial;Crystalline Lens;Data;Defect;developmental disease;Diagnosis;Disease;disease-causing mutation;Down-Regulation;Dysmorphology;Eukaryota;Eukaryotic Cell;experimental study;fibrillarin;Functional disorder;Genetic Diseases;Genetic Transcription;genome wide screen;genome-wide;histone methylation;Histones;Human;human disease;Human Genetics;innovation;Intellectual functioning disability;Knowledge;Laboratories;Life;loss of function;Malignant Neoplasms;MCF10A cells;Measures;Mediating;Membrane;Messenger RNA;Metabolism;metabolomics;Methodology;Methods;Methylation;Methyltransferase;Microcephaly;Mitochondrial Proteins;Morphology;Nature;Neurodevelopmental Impairment;next generation;novel;Organelles;Pathogenesis;Patients;Phenotype;Process;Protein Synthesis Inhibition;Proteins;Proteomics;Regulation;Research;Resistance;Ribosomal DNA;Ribosomal Proteins;Ribosomal RNA;Ribosomes;ribosomopathy;RNA methylation;RNA Processing;RNA, Ribosomal, 18S;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Seizures;Series;Small Interfering RNA;Sulfate;sulfite oxidase;Sulfites;Surface;System;Testing;Therapeutic;Translating;Uridine;Validation;Variant;Western Blotting;Work

PROJECT_TITLE: Defining a role for the mitochondrial protein sulfite oxidase in nucleolar ribosome biogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-A(20)L]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Infant Mortality;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Newark

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: PROJECT NARRATIVE Congenital heart disease (CHD) is a leading cause of newborn mortality worldwide. Defects in the development of the aortic arch arteries are common in CHD patients. Completing the studies outlined in this proposal will provide valuable insights into the physiological regulation of aortic arch artery formation and the alterations causing CHD.

PI_NAMEs: ASTROF, SOPHIE  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: 22q11;Address;Affect;Aorta;aortic arch;Applications Grants;Arteries;Bilateral;Birth;Blood Vessels;Branchial arch structure;cell assembly;Cell Count;cell motility;Cell Physiology;cell type;Cells;Chromosome abnormality;Circulation;confocal imaging;congenital heart abnormality;Cues;Data;Defect;Development;DiGeorge Syndrome;Dorsal;Embryonic Development;Endothelial Cells;endothelial stem cell;Endothelium;Extracellular Matrix;Fatal birth defect;Fibronectins;gastrulation;Genes;Genetic;Genetic Epistasis;Glycoproteins;Grant;Heart;Heterozygote;Human;Hypoplastic Left Heart Syndrome;Image;Immunofluorescence Immunologic;Immunofluorescence Microscopy;improved;In Situ Hybridization;insight;Integrins;Ipsilateral;KDR gene;Knowledge;Left;malformation;Mediating;Mesenchyme;Modeling;Molecular;Morphogenesis;mouse model;Mus;Mutagenesis;mutant;neonatal morbidity;Neonatal Mortality;Newborn Infant;Organ;Pathogenesis;Patients;Pattern;Pharyngeal structure;Phosphorylation;Physiological;Play;Positioning Attribute;Process;progenitor;Proteins;Publishing;receptor;Regulation;Role;Side;Signal Transduction;single-cell RNA sequencing;Stains;Structure;Syndrome;Testing;Thinness;transcription factor;Trees;Work

PROJECT_TITLE: Role of integrin a5b1 in vascular patterning and the formation of the pharyngeal arch arteries

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-K(02)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Substance Misuse

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Despite increasing use of cannabis during pregnancy, we know little about how prenatal cannabis exposure affects subsequent offspring psychopathology. The proposed project aims to leverage longitudinal modeling and machine learning approaches to: 1) characterize longitudinal associations between prenatal cannabis exposure and psychosis symptom outcomes; and 2) build classifiers from neural and behavioral markers of prenatal cannabis exposure. Findings will be integral to our understanding of the impact of prenatal cannabis exposure on psychosis outcomes in youth and will help inform predictive models of psychosis risk.

PI_NAMEs: AMIR, CAROLYN  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Adolescence;Adolescent;adolescent mental health;Adverse effects;Affect;Age;Age of Onset;Animals;Behavioral;Biological Factors;Biological Markers;Brain;Brain region;California;Cannabis;Child;Child Development;Childhood;Clinical;cognitive development;cohort;Collaborations;Corpus striatum structure;Data;design;Development;Dose;Early Intervention;Environment;Environmental Risk Factor;Exposure to;fetal marijuana exposure;financial incentive;follow-up;Foundations;Functional impairment;Functional Magnetic Resonance Imaging;Future;high risk;Impairment;improved;indexing;Individual;insight;Knowledge;life span;Link;Literature;longitudinal, prospective study;Los Angeles;Machine Learning;machine learning classifier;marijuana use;marijuana use disorder;marijuana use in pregnancy;Mental Health;Modeling;neural;neural circuit;Neurobiology;Neurocognitive Deficit;neuroimaging;Neurosciences;offspring;Outcome;Parents;Participant;Pathway interactions;Patients;Pattern;permissiveness;Plants;Policy Maker;preadolescence;predictive modeling;Pregnancy;Pregnant Women;prenatal;prepuberty;programs;Psychopathology;Psychoses;psychosis risk;psychosocial;psychotic;Psychotic Disorders;psychotic symptoms;psychotic-like experiences;Public Health;Recording of previous events;Recreation;Reporting;Research;reward anticipation;reward circuitry;reward processing;Rewards;Risk;Risk Factors;Role;Sampling;Severities;Shapes;Site;Statutes and Laws;substance use;Substance Use Disorder;Symptoms;Techniques;Tetrahydrocannabinol;Time;Training;United States;Universities;Work;Youth

PROJECT_TITLE: The Role of Prenatal Cannabis Exposure in Reward-related Neural Circuitry and Psychotic-like Experiences in Youth