ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

PHR: The obesity epidemic and its associated complications, including cardiovascular disease are leading health concerns in Veterans. Discovery of the fat-derived hormone leptin generated excitement as a weight loss therapy until it became clear that because of obesity-associated leptin resistance, leptin does not reliably lower body weight in humans with obesity. Oxytocin (OT) is an attractive therapeutic agent to treat obesity because it reduces body weight in diet-induced obese (DIO) rodents even in the presence of leptin resistance, and elicits cardioprotective effects in genetically obese rodents. We will determine if activation of hypothalamic OT neurons elicits cardioprotective effects in DIO mice and whether elevations of heart rate (HR) and blood pressure (BP) in DIO rodents are ameliorated by systemic OT alone or as an adjunct with beta-3 receptor agonists. These findings will direct future studies to test if intranasal OT reverses adverse cardiovascular effects associated with obesity in humans.

PI_NAMEs: BLEVINS, JAMES ERNEST (contact)

PROJECT_TERMS: Address;Adverse effects;Agonist;Area;Attenuated;Blood Pressure;blood pressure reduction;Body Composition;Body Weight;Body Weight decreased;Brain;Brown Fat;Cardiac;Cardiac health;Cardiac Myocytes;Cardiac Output;cardiometabolism;cardioprotection;Cardiovascular Diseases;cardiovascular effects;Cardiovascular Physiology;Cardiovascular system;Cells;Chronic;Combined Modality Therapy;Data;diet-induced obesity;dorsal motor nucleus;Dose;Drug Targeting;Eating;effective therapy;Energy Metabolism;Enterobacteria phage P1 Cre recombinase;Expenditure;Fat-Restricted Diet;Fatty acid glycerol esters;FDA approved;Female;Functional disorder;Future;Genetic;genetic approach;Health;Health Care Costs;Heart failure;Heart Rate;high risk;hindbrain;Histologic;Hormones;Human;Hypertension;Hypothalamic structure;Impairment;improved;Inbred SHR Rats;Inflammatory;Infrastructure;interest;Leptin;Leptin resistance;Lipids;male;Mediation;Medical;Metabolic;Modeling;Mus;Myocardial;Neurons;neurotransmission;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;Nucleus solitarius;Obese Mice;obese person;Obesity;Obesity Epidemic;obesity treatment;Outcome;Outcome Study;Oxytocin;Oxytocin Receptor;paraventricular nucleus;parvocellular;Pharmaceutical Preparations;pharmacologic;Play;Positioning Attribute;pre-clinical;Publishing;Rattus;receptor;reduced food intake;Regimen;Rodent;Rodent Model;Role;Signal Transduction;Spinal Cord;Sympathomimetics;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Thermogenesis;Thinness;Transgenic Mice;Translating;Veterans;weight loss intervention

PROJECT_TITLE: Oxytocin Signaling in the Control of Cardiometabolic Function in Diet-Induced Obesity


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Despite the ubiquity of cortical feedback connections and their likely role in neurological conditions including schizophrenia, attention disorders and autism, relatively little is known about their functional role. The optogenetic method used in the project enables the study of cortical feedback without contamination from untargeted brain areas, thus providing a cleaner view of the functional role of feedback than what has been previously possible. Thus, the understanding to be gained in the proposed research is likely to provide insight into these disorders, with potential for public health benefits.

PI_NAMEs: NURMINEN, LAURI  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Affect;Anesthesia procedures;Area;area striata;area V2;Attention;autism spectrum disorder;awake;Axon;Behavior;Biological Models;Brain;Callithrix;career;career development;Cells;Disease;Electric Stimulation;Electrodes;Electrophysiology (science);expectation;experimental study;extrastriate visual cortex;Feedback;Foundations;Functional disorder;Genetic Engineering;genome editing;Germ Lines;Goals;Health Benefit;Human;insight;Mediating;Mentors;Methods;Monkeys;neural;Neurologic;Neurons;Neurophysiology - biologic function;Neurosciences;optogenetics;Pathway interactions;Perception;Pharmacology;Phase;Positioning Attribute;post-doctoral training;Presynaptic Terminals;Primates;Property;Psychophysics;Public Health;receptive field;Research;response;Rewards;Role;Saccades;sample fixation;Schizophrenia;Sensory;Side;skills;Stimulus;success;Surface;Testing;tool;Training;Transgenes;transmission process;Travel;V1 neuron;Visual;Visual Cortex;visual information;Visual Perception;visual processing;visual stimulus

PROJECT_TITLE: Role of top-down feedback in visual perception

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The overarching goal of this multidisciplinary study is to provide a framework for bilingualism’s effect on the trajectory of healthy aging and Alzheimer’s disease, while accounting for the complexity underlying language experiences, executive functioning measures, and dementia types. The findings will improve care for people with diverse language backgrounds and give important insight into whether speaking more than one language can help prevent or slow the symptoms of Alzheimer’s disease and related dementias (ADRD).

PI_NAMEs: DELEON, JESSICA ANNE (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Area;Behavioral;bilingualism;Brain;Caring;cerebral atrophy;Clinical;clinical care;clinical phenotype;Cognition;Cognitive;cognitive performance;cohort;Data;Dementia;Development;Diagnosis;executive function;experience;Goals;gray matter;healthy aging;Imaging Techniques;improved;Individual;insight;Knowledge;Language;Maintenance;Measures;Memory;multidisciplinary;Multimodal Imaging;Nerve Degeneration;neural;neuroimaging;neuropathology;Neuropsychology;Pathology;Pattern;Performance;Persons;Population;Positioning Attribute;Positron-Emission Tomography;Predisposition;prevent;Primary Progressive Aphasia;Prospective, cohort study;protective effect;Research;resilience;Resistance;Role;social culture;sociocultural determinant;Structure;Symptoms;Syndrome;Testing;Time;Variant;Visuospatial;white matter

PROJECT_TITLE: The Role of Bilingualism in Cognitive and Brain Resilience: Addressing the Complexity


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Blunted or flat facial expression is characteristic of schizophrenia spectrum disorders, associated with negative symptoms and social impairment. However, there are no evidence-based treatments for decreased face expression, which is typically assessed through clinical observation and ratings. We will use computational analyses to quantify and operationalize face expression deficits during open-ended interview, including temporal patterns with speech and pauses, and nonverbal synchrony between participants and interviewers.

PI_NAMEs: CORCORAN, CHERYL MARY (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Acoustics;Address;Affect;Age;Anatomy;Archives;Australia;automated analysis;Behavior;Behavior assessment;Behavioral;Biological Markers;Canada;Characteristics;Chronic;Clinical;clinical high risk for psychosis;Clinical Trials;Code;Cognition;Cognitive;cohort;Companions;Complex;Computer Analysis;Computing Methodologies;Data;deep neural network;demographics;design;Development;early psychosis;Electromyography;Ethnic Origin;Evidence based treatment;Expressed Emotion;Eye;Face;Face Processing;Facial Expression;feature extraction;follow up assessment;functional outcomes;Funding;gaze;Genetic Transcription;Hearing;high risk;Image;Impairment;indexing;Individual;International;Interview;Interviewer;Label;Language;Longitudinal Studies;Measures;Methodological Studies;Modality;Modeling;Movement;multimodal data;multimodality;Muscle;National Institute of Mental Health;Natural Language Processing;non-verbal;novel;Outcome;Participant;Patients;Pattern;Persuasive Communication;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;processing speed;Property;Psychometrics;Psychoses;Research Domain Criteria;Risk;Role;Schizophrenia;schizophrenia spectrum disorder;Series;sex;Signal Transduction;Smiling;social;Speech;Stimulus;Stream;Symptoms;syntax;Testing;Time;Time Series Analysis;Variant;Voice;Work

PROJECT_TITLE: Computational phenotyping of face expression in early psychosis


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE The purpose of this application is to continue a highly successful 30-year training program in addiction research. Students will be trained to identify basic behavioral, neurobiological, and pharmacological processes involved in addiction and to translate that knowledge into effective clinical interventions and policy. Prior graduates of this program have done quite well at remaining involved in research, publishing articles on addiction, and becoming independent addiction researchers. We aim to continue this record of training success in the next funding period.

PI_NAMEs: HEIL, SARAH H;HIGGINS, STEPHEN T (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: behavioral pharmacology;Drug Use Disorder;Human

PROJECT_TITLE: Behavioral Pharmacology of Human Drug Use Disorders


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH Ultrasound imaging is safe, cost efficient, and easily accessible, which makes it an attractive imaging modality world-wide, and the potential for advanced ultrasound to dramatically impact patient care is enormous. However, given that benefits to patients cannot be realized before even the most exciting innovations are successfully converted into clinically available products, it is essential to train the next generation of ultrasound engineers for not only interdisciplinary technology development but also commercial translation of the technologies that emerge. The goal of the UNMUTED predoctoral training program is to provide trainees with the collaboration, technical, and commercialization skills necessary for transitioning advanced ultrasound research and development to commercially available products that meaningfully impact patient care.

PI_NAMEs: GALLIPPI, CATERINA M (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TITLE: The Unified Medical Ultrasound Technology Development (UNMUTED) Predoctoral Training Program


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: Narrative The MRI Resource for Physiologic, Metabolic and Anatomic Biomarkers is an interdepartmental and interdisciplinary consortium combining facilities and expertise of multiple departments and schools at the Kennedy Krieger Institute and the Johns Hopkins University. The goal of this National Center is to develop novel noninvasive MRI candidate biomarkers that can ultimately be used for (i) personalized assessment of patients for diagnosis, prognosis, and treatment monitoring (Precision Medicine), and (ii) expediting the development of new medical technologies and drugs. We will provide training in these new advanced technologies, and disseminate them to other research centers and hospitals in the country and worldwide.

PI_NAMEs: LU, HANZHANG ;VAN ZIJL, PETER CM (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: Academia;addiction;Address;Aging;Anatomy;Anemia;Area;Bayesian Method;Biological Markers;Biometry;Biopsy;Brain Diseases;Calibration;candidate marker;candidate validation;Cerebrovascular Disorders;Clinic;Clinical;clinical care;clinical outcome assessment;clinical practice;Clinical Trials;Complex;Computer software;computerized data processing;Consensus;Contrast Media;Country;Critical Pathways;Data;data acquisition;Data Analyses;Data Set;Decision Making;deep learning;Dementia;design;Detection;Development;Diagnosis;Diagnostic;Disease;drug development;Engineering;Ensure;Evaluation;Failure;Fingerprint;Foundations;Future;glymphatic function;Goals;Hospitals;imaging biomarker;imaging facilities;imaging science;improved;In Situ;Industry;Injections;Injury;innovation;investigator training;Ischemia;Joints;Lesion;Libraries;Machine Learning;Magnetic Resonance;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Magnetic Resonance Spectroscopy;Manufacturer;Measures;Medical;medical schools;Medical Technology;Metabolic;Methods;Monitor;multi-scale imaging data;multimodality;multiscale data;novel;outcome prediction;Pain;Patient Care;Patients;Pharmaceutical Preparations;Pharmacodynamics;Physiologic pulse;Physiological;precision medicine;Process;product development;Prognosis;prognostic;Property;Public Health Schools;public-private partnership;Qualifying;quantitative imaging;Radiology Specialty;Readiness;Reporting;Reproducibility;Research;Research Personnel;Resources;response biomarker;Sampling;Schools;Science;Services;Site;Speed;Standardization;success;Techniques;Technology;Terminology;Testing;Therapeutic;Tissues;tool;Training;training data;Translating;Translational Research;Traumatic Brain Injury;United States National Institutes of Health;Universities;Validation;Visualization;Vocabulary;Water;White Matter Hyperintensity;working group


PI_NAMEs: VAN ZIJL, PETER CM (contact)

PROJECT_TERMS: Advisory Committees;Anatomy;Area;Baltimore;Beds;Biological Markers;biomarker development;Biomedical Engineering;Biometry;Brain imaging;Clinic;Collaborations;collaborative environment;Computer software;contrast imaging;data exchange;Dedications;design;Development;Engineering;Environment;Equipment;Equity;experience;Faculty;Goals;Grant;Head;Health;Human;Image;imaging facilities;imaging science;Imaging technology;Institution;Interdisciplinary Study;interest;International;Internet;investigator training;Letters;Magnetic Resonance;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maintenance;Medical;medical schools;member;Metabolic;Methodology;multimodality;National Institute of Biomedical Imaging and Bioengineering;new technology;operation;organizational structure;Physiological;Procedures;professor;Progress Reports;Protocols documentation;Public Health Schools;Radiology Specialty;Reporting;Research;research and development;Research Project Grants;Resources;Review Committee;Safety;Scheme;Schools;Scientist;Services;Site;Spectrum Analysis;success;System;Technology;technology development;Testing;Training;Translating;United States National Institutes of Health;Universities;Validation

PROJECT_TITLE: Center Administration


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MINNEAPOLIS

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Sepsis strikes ~ 2 million Americans annually; most of these patients will survive the acute stage of sepsis only to end up back in the ICU, weeks later, with hospital-acquired infections. The objective of this proposal is to rigorously study how sepsis leads to the dysfunction and reprogramming of effector and regulatory CD4 T cells. Our planned studies will integrate discovery approaches (e.g., genomics, metabolomics, proteomics) with hypothesis-driven studies to rigorously study CD4 T cell populations from pediatric and adult septic patients and experimental sepsis models in both SPF and ‘dirty’ mice.

PI_NAMEs: GRIFFITH, THOMAS S (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Activities of Daily Living;Acute;Address;Adult;Affect;American;Area;Back;Cause of Death;CD4 Positive T Lymphocytes;Cell Compartmentation;Cells;Cellular biology;Cellular Immunity;Cessation of life;Childhood;Chronic;cohort;cost;cytokine;cytokine release syndrome;emerging pathogen;Exposure to;fitness;Functional disorder;Future;Genomics;Goals;gut microbiota;Healthcare Industry;Human;Human Biology;Immune;immune function;Immune response;Immune system;Immunosuppression;Impairment;Incidence;Infection;Inflammatory;Interferon Type II;Interleukin-1 beta;Interleukin-6;Intervention;Investigation;Knowledge;Laboratory mice;Life;metabolomics;Modeling;Molecular;mortality;mouse model;Mus;Nosocomial Infections;novel;Organ;pathogen;Patients;Phase;Play;Population;pre-clinical;preclinical study;Predisposition;Proteomics;Regulatory T-Lymphocyte;Reporting;Research;response;Sampling;secondary infection;Secondary to;Sepsis;septic patients;Survivors;Time;TNF gene;Training

PROJECT_TITLE: CD4 T cell dysfunction and reprogramming during sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Osteoporosis and osteoarthritis cumulatively affect more than 40 million Americans and result in annual healthcare costs of more than $50 billion, but remain undertreated because of the limited accuracy of existing tools for risk stratification and disease and treatment monitoring. Recently, CT manufacturers began introducing new ultra-high resolution CT (UHR CT) scanners capable of visualizing details approaching the size of the microstructures of human bone. We will investigate whether the UHR CT scanners, combined with novel image analysis techniques, can provide new information on bone health that will improve diagnosis and treatment of osteoporosis and osteoarthritis.

PI_NAMEs: ZBIJEWSKI, WOJCIECH BARTOSZ (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: Affect;Algorithms;American;Biological Markers;Biological Models;biomechanical test;Body Size;bone;Bone Density;Bone Growth;bone health;bone quality;cartilage degradation;Clinical;clinical biomarkers;clinical development;Competence;cone-beam computed tomography;Degenerative polyarthritis;detector;Diagnosis;Diagnostic Imaging;Disease;Dose;Dual-Energy X-Ray Absorptiometry;Early Diagnosis;Emerging Technologies;experimental study;Failure;Forteo;fracture risk;Generations;Geometry;Goals;Health Care Costs;High Resolution Computed Tomography;high resolution imaging;Human;Image;Image Analysis;imaging modality;imaging system;improved;in vivo;in vivo evaluation;interest;Investigation;Light;Magnetic Resonance Imaging;Manufacturer;Measurement;Mechanics;Mediating;meter;microCT;Monitor;Morbidity - disease rate;mortality;Noise;novel;Operative Surgical Procedures;Orthopedics;Osteoporosis;Outcome;Patients;Performance;Perioperative;Pharmaceutical Preparations;preclinical study;prevent;Process;prospective;Protocols documentation;Quantitative Evaluations;radiological imaging;radiomics;reconstruction;Reproducibility;Research;Resolution;Risk Assessment;Risk Estimate;risk stratification;Roentgen Rays;Sampling;Scanning;simulation;spectrograph;Spinal Fusion;spine bone structure;Standardization;Structure;subchondral bone;substantia spongiosa;System;Techniques;Technology;Texture;Thick;tool;Trabecular Bone Score;ultra high resolution;Validation;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: Quantitative bone radiomics using Ultra-High Resolution CT

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Cerebrovascular;Data Science;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Precision Medicine;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: This TRD will develop new MRI techniques to provide researchers and clinicians with the ability to assess the brain’s physiology, such as blood supply, brain’s oxygen consumption, leakage of blood-brain barrier, blood vessel’s responses to carbon dioxide and blood pressure changes. To achieve these goals, we will develop new MRI techniques and integrate other state-of-the-art technologies. These methods will be made available to a variety of NIH-funded projects led by investigators working on different MRI scanners and for them to study several devastating brain diseases.

PI_NAMEs: LU, HANZHANG  (contact)

PROJECT_TERMS: 3-Dimensional;Alzheimer's Disease;Amyloid;anatomic imaging;Anatomy;Area;arterial spin labeling;Attention;Benchmarking;Big Data;Biological Markers;Biophysics;Blood - brain barrier anatomy;Blood Pressure;Blood Vessels;blood-brain barrier permeabilization;Bolus Infusion;Brain;Brain Diseases;candidate marker;Carbon Dioxide;Cerebrovascular Circulation;cerebrovascular reactivity;Clinical;clinical outcome assessment;Clinical Trials;cloud based;Collaborations;computerized data processing;contrast imaging;Data Analyses;deep learning;Dementia;density;Development;diagnostic biomarker;Diffuse;Disease;Ensure;Extravasation;Fingerprint;Functional Imaging;Functional Magnetic Resonance Imaging;Funding;Future;Gases;Glutathione;Goals;Image;image reconstruction;Impaired cognition;improved;Inhalation;interest;Lead;Magnetic Resonance Imaging;Magnetism;Maps;Measurement;Measures;Metabolic;metabolic rate;method development;Methods;Modeling;Monitor;Multi-Institutional Clinical Trial;Multicenter Studies;Nature;Neurosciences;novel;Outcome Measure;Oxidative Stress;Oxygen;Oxygen Consumption;participant enrollment;Pathology;patient population;Patient Selection;personalized medicine;Pharmacologic Substance;Phosphocreatine;Physiologic pulse;Physiological;Physiology;Positron-Emission Tomography;Predisposition;Principal Investigator;professor;Property;quantitative imaging;Radiology Specialty;Readiness;reconstruction;Relaxation;Reproducibility;Research;Research Personnel;Resources;response;Role;Sampling;Services;Sickle Cell Anemia;Signal Transduction;Slice;Speed;Standardization;statistics;synergism;tau Proteins;technique development;Techniques;Technology;Testing;Time;time use;Tissues;tool;treatment effect;Treatment outcome;United States National Institutes of Health;Vascular blood supply;vascular contributions;Vascular Dementia;Vendor

PROJECT_TITLE: TRD1: Quantitative Imaging of Physiological Markers


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Infectious Diseases;Substance Misuse

ORG_CITY: ROCKVILLE

ORG_NAME: AMERICAN SOCIETY OF ADDICTION MEDICINE

PHR: PROJECT NARRATIVE Project Narrative The primary goal of the International Society of Addiction Medicine (ISAM) is to organize/present annual conferences disseminating the most current research on addiction medicine in countries with relatively few resources, thereby helping local clinical addiction medicine experts in setting up necessary addiction/clinical medicine services and research. ISAM’s Annual Meeting is unique in its focus on international/cultural diversity and in bringing together a cross-sectional, multi-national group of professionals with a common interest in research, clinical practice and training aspects of addiction medicine. The meeting design allows for input/exchange by all participants and provides a forum that facilitates formal and informal analysis/integration of clinical experience and research findings.

PI_NAMEs: BUNT, GREGORY CHARLES (contact);POTENZA, MARC N

PROJECT_TERMS: Abu Dhabi;addiction;Affect;Area;ATOD;Award;Behavior;Behavioral;Canada;career;Child;Clinical;Clinical Medicine;clinical practice;clinical training;Collaborations;Communicable Diseases;comorbidity;Country;COVID-19;Cultural Diversity;design;Development;Discipline;Disease;Drug Addiction;Educational Status;Egypt;Electronic Mail;Elements;Epidemiologist;ethnic diversity;Ethnic Origin;Etiology;Evaluation;Event;experience;Fellowship;Fostering;Funding;Future;Gender;Geographic Locations;Goals;graduate student;Grant;Health Professional;Hepatitis C virus;HIV;Homelessness;Immunologist;Imprisonment;improved;India;Individual;Infection;innovation;Institution;interest;Interest Group;International;Italy;Japan;Journals;Korea;lectures;Location;Malaysia;Medical;medical specialist;Medicine;meetings;member;Mental disorders;Mental Health;Mentors;Mentorship;Minority Groups;multi-racial;multidisciplinary;National Institute of Drug Abuse;Nature;next generation;Norway;Opioid;Participant;Persons;Population;Postdoctoral Fellow;posters;Prevention;Process;Professional Organizations;programs;Public Health;Publications;Publishing;pulmonary function;Race;racial diversity;Recording of previous events;Research;Research Personnel;Resources;Science;Scientist;Scotland;Services;Smoking;social;Societies;South Africa;Stimulant;Structure;Substance abuse problem;Substance Addiction;substance use;Substance Use Disorder;substance use treatment;success;Switzerland;symposium;Technology;Training;training opportunity;Travel;vaping;Videoconferencing;virtual;web site;webinar;Work;Writing

PROJECT_TITLE: International Society of Addiction Medicine Annual Conference


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE The proposed continuation of our NRSA Training Program in Surgical Innovation will provide pre-doctoral biomedical engineers the collaborations, experience and state-of-the-art knowledge, skills, and tools to become leaders in surgical innovation. Trainees will learn new technology development and validation, take advantage of existing NIH funding and unique resources at Dartmouth, and pursue careers that will replace the haphazard, industry-driven approach to surgical innovation with a structured, multi-disciplinary, problem-solving approach.

PI_NAMEs: FOSSUM, ERIC R;MIRZA, SOHAIL K;PAULSEN, KEITH D. (contact)

PROJECT_TITLE: Training in Surgical Innovation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: MADISON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The proposed research is extraordinarily relevant to public health. Our human data will provide the foundation for identifying DNA methylation profiles in blood that predict the progression and expression of late onset Alzheimer’s disease (LOAD). Conventional biomarkers for Alzheimer’s disease are costly, invasive, and must be performed in select locations by specialists, thereby reducing their utility for population-wide diagnosis and prognosis. Accordingly, the present proposal expressly addresses NIA’s mission with the discovery and validation of reliable and practical Alzheimer’s disease blood biomarkers. Blood biomarkers configured for use in primary-care settings will detect deviations from healthy cognitive trajectories over the lifespan, identify modifiable Alzheimer’s disease risk factors and interventions, and coordinate research efforts with an epigenetic metric that integrates heritable and acquired variables that influence aging.

PI_NAMEs: ALISCH, REID SPENCER (contact);HOGAN, KIRK J

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Acceleration;Address;Adult;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-42;Auditory;Biological Markers;Blood;Brain;brain tissue;Cerebrospinal Fluid;Clinical;clinical diagnosis;clinical predictors;Cognitive;Cognitive aging;Cost of Illness;Data;Dementia;Diagnosis;Disease Marker;disease phenotype;disease prognosis;disorder risk;DNA;DNA Methylation;Early Intervention;Enrollment;Epigenetic Process;epigenome;epigenome-wide association studies;Etiology;Female;follow-up;Foundations;Genes;genome sequencing;Hematological Disease;Heritability;human data;Human Genome;human old age (65+);improved;Intervention;Investigation;Late Onset Alzheimer Disease;life span;Location;male;men;Methylation;methylation biomarker;mild cognitive impairment;Mission;modifiable risk;Neurodegenerative Disorders;Neurofilament Proteins;neurogranin;neuroimaging;novel;novel diagnostics;older adult;Oxidoreductase;Participant;Pathogenesis;Pathway interactions;Patients;Peripheral;Persons;Phenotype;phenotypic data;Population;Positioning Attribute;primary care setting;Prognosis;prognostic;Prostaglandins;Psychometrics;Public Health;Reporting;Research;Risk;Risk Factors;Sampling Studies;Signs and Symptoms;Site;Specialist;Superior temporal gyrus;Symptoms;tau Proteins;tau-1;Testing;therapeutic target;Time;Tissues;Validation;Verbal Learning;whole genome;Wisconsin;Woman;Women's cohort

PROJECT_TITLE: Blood DNA Methylation Biomarkers of Alzheimer's Disease


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Diabetes

ORG_CITY: LOS ANGELES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Glycolysis and gluconeogenesis are functionally opposite metabolic pathways that support systemic glucose homeostasis in humans. This project will map kinetic and thermodynamic properties of the two pathways and elucidate regulatory mechanisms that enable seamless transitions and coordination between them. The resulting knowledge will advance therapeutic development for diabetes and cancer.

PI_NAMEs: PARK, JUNYOUNG O. (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Adopted;Biomass;Biotechnology;blood glucose regulation;Carbon;Carbon Dioxide;Control Groups;Diabetes Mellitus;Disease;Economics;Engineering;Enzymes;experimental group;Gluconeogenesis;Glucose;Glycolysis;Goals;Human;innovation;Isotopes;Kinetics;knowledge of results;liquid chromatography mass spectrometry;Malignant Neoplasms;Mammalian Cell;Maps;mathematical model;Mathematics;Measures;Medicine;Metabolic Control;metabolic engineering;Metabolic Pathway;Metabolism;Microbe;microbial;Mind;new technology;Non-Insulin-Dependent Diabetes Mellitus;novel;Organism;oxidation;Pathway interactions;programs;Property;Regulation;Research;Research Personnel;System;Techniques;Technology;therapeutic development;Thermodynamics;Tracer

PROJECT_TITLE: Elucidating the mechanism behind oscillation between glycolysis and gluconeogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: KNOXVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: Candida albicans is the most common cause of human fungal infections, including life-threatening invasive infections. Improvement in patient outcomes will be possible by enhancing immune responses to the fungus. This proposal will study a signaling pathway in C. albicans that can be activated to cause the fungus be more readily visible to the immune system.

PI_NAMEs: REYNOLDS, TODD B (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: ACE2;Address;Alleles;anti-fungal agents;Antifungal Therapy;Architecture;Biology;Candida;Candida albicans;Carbohydrates;Caspofungin;cell type;Cell Wall;Cells;Cellular biology;Chitin;Cytolysis;Death Rate;Decision Making;dectin 1;Detection;Epitopes;Exhibits;experimental study;Feedback;fungus;Genes;Genetic;genetic approach;Genetic Epistasis;Genetic Transcription;glucan synthase;Glucans;Glycoproteins;Goals;Health;Human;Hyperactivity;Immune;Immune response;Immune system;Immunologic Receptors;improved;In Vitro;Infection;Life;LoxP-flanked allele;Macrophage;Macrophage-1 Antigen;Mammals;Mannans;MAP Kinase Modules;Masks;Mediating;Mitogen-Activated Protein Kinases;Molecular;Mus;mutant;Mycoses;neutrophil;novel;overexpression;Overlapping Genes;Pathway interactions;Patient-Focused Outcomes;Pharmaceutical Preparations;Polymers;Proteins;receptor;Regulation;Research;Services;Signal Pathway;Signal Transduction;Stress;Systemic infection;Techniques;Technology;Testing;tool;trait;transcription factor;Transgenic Mice;upstream kinase;Virulence

PROJECT_TITLE: Regulation of ß(1,3)-glucan exposure in Candida albicans

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Machine Learning and Artificial Intelligence;Neurosciences

PHR: This TRD will develop new methods to measure biomarkers of brain chemistry using an MRI scanner, both by directly detecting signals from small molecules in the brain (with edited magnetic resonance spectroscopy MRS) and indirectly (using the contact between protons in the metabolites and water) with amplification by detection through the water signal). These two methods will also be integrated using machine learning to benefit from their complementary strengths of detection specificity and detection sensitivity, respectively.

PI_NAMEs: EDDEN, RICHARD ANTHONY EDWARD (contact)

PROJECT_TERMS: Affect;amplification detection;Anatomy;Antioxidants;base editing;Binding;Biochemical;Biochemistry;Biological Markers;Brain;brain abnormalities;Brain Chemistry;Brain imaging;brain metabolism;Chemicals;Collaborations;Communities;Coupling;Data;Data Analyses;Data Set;Decision Making;deep learning;design;Detection;detection sensitivity;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;Fingerprint;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Glutamates;Glutathione;Image;Immobilization;improved;innovation;interest;Label;Lead;Libraries;Machine Learning;macromolecule;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Magnetism;Measurement;Measures;Metabolic;metabolic imaging;Metabolic Marker;Methods;Modeling;Molecular;Monitor;N-acetylaspartylglutamate;Nervous System Disorder;Neuromodulator;Neurotransmitters;Oncology;open source;Phosphocreatine;Physiologic pulse;Physiological;Preparation;Principal Investigator;professor;Property;Proteins;Protons;Radiology Specialty;Relaxation;Reproducibility;Research Personnel;Resolution;Resources;response;Schedule;Scheme;Services;Shapes;Signal Transduction;small molecule;Specificity;spectroscopic imaging;statistics;synergism;System;Techniques;Testing;tool;Training;training data;Validation;Water

PROJECT_TITLE: TRD 2: Metabolic Markers


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Pancreatic cancer remains a deadly and treatment resistant malignancy in large part due to significant stromal desmoplasia and an immunosuppressive tumor microenvironment (TME). This proposal seeks to elucidate if targeting a master regulator of the TME, focal adhesion kinase, can alter the stroma and immunosuppressive TME in order to sensitize pancreas cancer to immunotherapy. By employing a neoadjuvant translational research strategy combined with expert mentorship, hands-on training and intensive didactics, these challenges of pancreatic cancer can be addressed with the ultimate goal of reversing the grim clinical outcomes of patients with this deadly disease.

PI_NAMEs: OSIPOV, ARSEN  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adjuvant Chemotherapy;anti-cancer research;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;anti-tumor immune response;antibody conjugate;arm;bench to bedside;Biology;biomarker panel;Biopsy;cancer immunotherapy;cancer therapy;Carcinoma;career;career development;CD8-Positive T-Lymphocytes;Cementation;checkpoint inhibition;chemotherapy;Clinical;clinical translation;Clinical Trials;Coculture Techniques;Combination immunotherapy;Combined Modality Therapy;Complex;Comprehensive Cancer Center;Coupled;Culture Techniques;CXCR4 gene;Cytotoxic Chemotherapy;density;design;Desmoplastic;Development Plans;Disease;disorder control;effector T cell;Environment;Excision;experience;Fibroblasts;Focal Adhesion Kinase 1;Future;Gene Expression Profile;Generations;Genes;genetic signature;Goals;Growth;high risk;Human;human tissue;Hyaluronic Acid;Immune;Immunohistochemistry;Immunologic Surveillance;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In complete remission;Inflammatory;innovation;International;Investigation;K-Series Research Career Programs;kinase inhibitor;KPC model;Laboratory Research;Learning;Lymphoid;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Mentors;Mentorship;mouse model;Myelogenous;Myeloid Cells;Neoadjuvant Therapy;neoplastic;neoplastic cell;neutrophil;novel;Oncologist;open label;Operative Surgical Procedures;Outcome;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathologic;Patient-Focused Outcomes;Patients;PD-1 inhibitors;pembrolizumab;Phase II Clinical Trials;Phenotype;Phosphorylation;Population;pre-clinical;precision oncology;Production;Randomized;Reactive Oxygen Species;Recurrence;Recurrent disease;Refractory;Regulatory T-Lymphocyte;Relapse;Research;Research Personnel;Resectable;Resistance;response;Role;Safety;Science;Signal Transduction;Sorting;Source;Specimen;Stains;Stromal Cells;success;Systemic disease;T cell infiltration;T cell response;T-Lymphocyte;Techniques;Testing;Therapeutic Intervention;Tissue Model;Tissues;Training;transcriptome sequencing;Translating;translational approach;Translational Research;Translations;treatment response;tumor;tumor microenvironment;tumor-immune system interactions;Work

PROJECT_TITLE: Targeting the Stroma for Pancreatic Cancer Treatment

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Cancer is the second most common cause of death in the USA. Mad1 (Mitotic arrest deficient 1) is commonly upregulated in cancer, where it serves as a marker of poor prognosis. The experiments in this proposal will define the role of Mad1 upregulation in tumor formation and metastasis, with the ultimate goal of developing novel treatments to improve cancer patient outcomes.

PI_NAMEs: WEAVER, BETH A (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Acceleration;Alleles;antagonist;Binding;Biochemistry;Breast Cancer Model;C-terminal;Cancer Patient;Cancerous breast;Cause of Death;Cell Cycle;Cell Cycle Checkpoint;cell motility;Cells;Cellular biology;Chromosomal Instability;chromosome missegregation;Clinical Trials;CRISPR/Cas technology;Defect;Dependence;Diagnosis;Disease;ECM receptor;experimental study;Fibronectins;Genes;Goals;Golgi Apparatus;Immune system;Immunocompromised Host;Impairment;improved;inhibitor;innovation;Integrin Inhibition;Integrins;Interphase;ITGA5 gene;Light;Mad1 protein;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mass Spectrum Analysis;Mediating;Membrane;Messenger RNA;Microscopy;Mitosis;Mitotic;Mitotic Activity;Mitotic Checkpoint;Modeling;Motility;mouse model;Mus;mutant;Mutate;Neoplasm Metastasis;new therapeutic target;novel;orthotopic breast cancer;overexpression;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Play;prevent;Primary Neoplasm;Prognosis;promoter;Proteins;Publishing;Role;Series;Signal Transduction;Testing;Tetanus Helper Peptide;Tetracyclines;TP53 gene;trafficking;tumor;tumor growth;tumor initiation;tumor progression;Tumor Promotion;tumorigenesis;Up-Regulation;Woman;Work

PROJECT_TITLE: Non-canonical roles of Mitotic Arrest Deficient 1 (Mad1) in tumor promotion

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative: Fetal Alcohol Spectrum Disorders (FASD) result from embryonic exposures to alcohol and affect 2-5% of school- aged children in the US. The diversity of clinical symptoms including facial dysmorphology, cognitive and behavioral deficits, associated with disorders within FASD make both diagnosis and treatment a challenge. This project will investigate how prenatal alcohol exposure may result in aberrant development of circuits in the striatum and relate to early motor deficits common to both animal models of prenatal alcohol exposure, and FASD patients.

PI_NAMEs: TOUSLEY, ADELAIDE R (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Affect;alcohol exposure;Alcohols;Animal Model;Area;Basal Ganglia;Behavior;Behavioral;biocytin;Birth;Cells;Child;cholinergic;Clinical;Cognitive;Cognitive deficits;Complex;Corpus striatum structure;Data;Development;Diagnosis;Disease;DNA cassette;Dysmorphology;Early Intervention;Electrophysiology (science);Embryo;Ethanol;experimental study;Exposure to;Face;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fishes;Foundations;Frequencies;gamma-Aminobutyric Acid;Ganglia;Glutamates;Goals;improved;inducible Cre;Injections;insight;Internal Ribosome Entry Site;Interneurons;LoxP-flanked allele;Measures;Medial;Mediating;Membrane;migration;Morphology;Motor;motor behavior;motor control;Motor Cortex;motor deficit;Motor Skills;mouse model;Movement;Mus;neocortical;Neonatal;neonatal mice;neural circuit;neurodevelopment;Neurodevelopmental Disability;Neurons;non-genetic;novel marker;optogenetics;Outcome;patch clamp;Patients;Phenotype;Physicians;Physiological;Pilot Projects;Play;postnatal;pregnant;Property;prospective;Quality of life;Reporter;Research;Role;School-Age Population;Scientist;sensory cortex;sensory input;Series;Signal Transduction;somatosensory;Source;Symptoms;Synapses;synaptic function;Synaptic plasticity;targeted treatment;Technical Expertise;Teratogens;Testing;Thalamic structure;Transgenic Mice;Vertebral column;Viral;voltage clamp;Work

PROJECT_TITLE: Prenatal alcohol exposure, GABAergic interneuron circuitry, early motor behavior, and the developing striatum


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Natural Products;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE More than half of the 80 million stroke survivors worldwide experience persistent walking difficulties that impact their mobility, social interaction, and quality of life. Ankle joint stiffness and viscosity are fundamental mechanical descriptions that impact an individual's walking ability, yet these descriptions are typically not considered during the clinical decision-making process, primarily due to the lack of understanding of how these properties contribute to post-stroke gait function and the difficulty in assessing them in a clinical setting. The proposed grant will investigate how ankle joint stiffness and viscosity influence post-stroke walking function, as well as establish a new tool to measure these properties easily in the clinic, which will advance clinical knowledge and improve the treatment of individuals post-stroke, and ultimately enhance the quality of life of millions of stroke survivors.

PI_NAMEs: KRISHNAN, CHANDRAMOULI ;ROUSE, ELLIOTT J (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Address;Affect;Age;Ankle;ankle joint;Bilateral;Biomechanics;botulinum neurotoxin injection;botulinum toxin treatment;Botulinum Toxins;Clinic;Clinical;clinical decision-making;Data;Equipment;Evaluation;Exhibits;experience;Fostering;Foundations;Functional disorder;functional outcomes;Funding;Gait;Gait abnormality;Goals;Grant;Impairment;improved;improved mobility;Individual;Injection of therapeutic agent;Injections;innovation;insight;Intervention;Investigation;joint stiffness;Joints;Knowledge;Leg;Locomotion;Manuals;Measurement;Measures;mechanical properties;Mechanics;Motion;Movement;Muscle;Nervous System Trauma;novel;Orthotic Devices;Outcome;Patient Care;Patients;Persons;Pharmaceutical Preparations;Phase;post stroke;Process;Property;Qualifying;Quality of life;Research;Resistance;response;Rest;Side;Social Interaction;spasticity;statistics;stem;Stroke;stroke rehabilitation;stroke survivor;stroke therapy;Symptoms;System;Techniques;Testing;Time;tool;Torque;Viscosity;Visual;Walking;Work

PROJECT_TITLE: Functional implications of stroke and Botulinum Neurotoxin on ankle stiffness and viscosity during gait

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


PHR: The overall goal of this project is to design pulse sequences and analysis approaches to efficiently quantify MRI parameters that reflect tissue composition and microstructure. These parameters will be used to synthetically generate multiple image contrasts (synthetic MRI), including conventional ones with which the radiologists are familiar for reading and that currently can be acquired only separately. In addition we will develop methods for high resolution mapping of white matter brain tracts.

PROJECT_TERMS: Affect;age related;Anatomy;Anisotropy;Atlases;Biological Markers;Biological Process;Blood;Brain;brain tract;Calcium;candidate marker;Characteristics;contrast imaging;Data;deep learning;density;design;Development;Diagnostic;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Ferritin;Fiber;Fingerprint;Frequencies;Goals;gray matter;Head;Hemoglobin;high resolution imaging;Image;imaging biomarker;Imaging Device;imaging study;in vivo;in vivo imaging;Iron;Label;Lead;Libraries;Lipids;magnetic field;Magnetic Resonance Imaging;Magnetism;Maps;Measurement;Measures;Metabolic;Methods;Microscopic;Molecular;Motion;Myelin;Organ;Pathogenicity;Permeability;Phase;Physiologic pulse;Physiological;potential biomarker;Predisposition;Principal Investigator;Process;professor;Property;Proteins;Protons;quantitative imaging;radiologist;Radiology Specialty;Reading;reconstruction;Relaxation;Reporting;Research Personnel;Resolution;Resources;response;Rotation;Shapes;Signal Transduction;statistical learning;Structure;synergism;Technology;Testing;Therapeutic Intervention;Time;Tissues;tractography;Universities;Variant;Water;water diffusion;white matter

PROJECT_TITLE: TRD 3: MRI parameters reflecting tissue composition and microstructure


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Hypertension continues to grow in the US and worldwide, representing one of the greatest burdens in human health as it contributes to the development of cardiovascular disease and premature death. Four decades of scientific research of enhancing the pGC-A/cGMP pathway has demonstrated its favorable blood pressure lowering and protective biological actions, and thus, represents a novel therapeutic target for hypertension. This proposal aims to advance the biology, as well as to optimize a novel pGC-A small molecule stimulator, engineered by the applicants, with the ultimate goal of providing a new class of drugs to treat hypertension, specifically resistant hypertension, for which there are no approved drugs.

PI_NAMEs: MALANY, SIOBHAN ;SANGARALINGHAM, SASANTHA JESON (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: ADME Study;Adrenal Glands;adverse outcome;Aldosterone;Apoptosis;Arteries;atrial natriuretic factor receptor A;Binding;Biological;Biological Availability;Biology;Blood Pressure;blood pressure reduction;Brain natriuretic peptide;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cells;Cessation of life;Chemosensitization;Chronic;Chronic Kidney Failure;Clinical;clinical candidate;Coronary artery;coronary event;Cyclic GMP;design;Development;Diuresis;Dose;drug discovery;Drug Kinetics;Drug Targeting;efficacy study;Endocrine Glands;Endothelial Cells;Engineering;Enzyme Inhibition;FDA approved;Fibrosis;Funding;Generations;Genes;Genetic;genetic variant;Goals;Health;Heart;Heart Atrium;Heart failure;Heart Hypertrophy;high risk;high throughput screening;Homeostasis;Hormones;Human;Human Genetics;Hypertension;Hypertrophy;improved;In Vitro;in vivo;Inbred SHR Rats;Inflammation;Injectable;Kidney;Lead;lead optimization;Ligands;Measurement;Mediating;Metabolic;Molecular Bank;Molecular Target;Mus;Natriuresis;new therapeutic target;novel;novel drug class;novel therapeutics;Oral;Oral Administration;Particulate;Pathway interactions;Patients;Peptides;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Plasma;positive allosteric modulator;premature;Production;Proliferating;Property;protective effect;prototype;receptor;Receptor Activation;Renin-Angiotensin-Aldosterone System;repository;Research;Resistant Hypertension;Risk;scaffold;Second Messenger Systems;Signal Transduction;small molecule;small molecule libraries;small molecule therapeutics;Stroke;System;Therapeutic;therapeutic target;Time;United States National Institutes of Health;urinary;Vasodilation;Work

PROJECT_TITLE: Novel  Therapeutics for Cardiovascular Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Racial and Ethnic Minority Health Research

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE The percentage of bilingual learners in the US is expected to rise to 25% by 2030; Chinese is the third most common language in the US. The aims of this proposal are to identify cognitive mechanisms that optimize the success of literacy development in young Chinese-English bilinguals with developmental dyslexia which affects 6% of the population, regardless of bilingualism status to help early identification and targeted remediation for bilinguals with dyslexia.

PI_NAMEs: KOVELMAN, IOULIA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TITLE: Bilingual and cross-cultural investigation of developmental dyslexia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-N(02)M]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

PHR: In this TRD, we will develop MRI brain data analysis methods that incorporate the latest signal processing and data science technologies, including deep learning. This TRD will closely interact with other TRDs and integrate their data in multi-contrast images.

PI_NAMEs: MORI, SUSUMU  (contact)

PROJECT_TERMS: Algorithms;Anatomy;Area;Atlases;Axon;Biological Markers;Biomedical Engineering;Biometry;Brain;Brain Diseases;brain magnetic resonance imaging;Brain Mapping;Collaborations;Collection;Complex;Computer software;contrast imaging;Data;data acquisition;Data Analyses;Data Science;deep learning;Detection;Development;Diffusion;Dimensions;Engineering;Etiology;experience;frontier;Image;image archival system;image registration;imaging modality;imaging Segmentation;improved;Investments;Label;Lead;Learning;Lesion;Magnetic Resonance Imaging;Maps;Metabolic;Methods;Modality;Modeling;Modernization;multi-scale imaging data;multimodality;Names;new technology;Output;Pathologic;Pathology;Performance;Perfusion;Physiological;Positioning Attribute;prediction algorithm;predictive modeling;Predisposition;Principal Investigator;professor;Prognosis;prospective;Radiology Specialty;reconstruction;Research Personnel;Resolution;Resources;Role;signal processing;statistics;success;Technology;Testing;Time;tool

PROJECT_TITLE: TRD 4: Platforms for multi-modal and multi-scale imaging data


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Prevention;Rare Diseases;Stomach Cancer

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE Gastric cancer is a global health problem, especially in Northeastern China. This application is for a collaborative approach harmonizing US and China partners. The US group will investigate basic science mechanisms of genes involved in how precancerous lesions (metaplasias) arise, and the Chinese group will provide appropriate clinical samples of patients with gastric cancer. The Chinese group will also help with sequencing and modeling the tumor-forming aspects of specific genes in mice.

PI_NAMEs: MILLS, JASON C (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: 3-Dimensional;Acids;Affect;Atrophic;Atrophic Gastritis;Autophagocytosis;Back;Bacteria;Basic Science;Bioinformatics;Biological Markers;cancer risk;Cancerous;CD44 gene;Cell Cycle;Cell Differentiation process;cell injury;cell type;Cells;Cessation of life;Chief Cell;China;Chinese population;Chronic;Clinical;Clinical Data;Collaborations;collaborative approach;Complex;Data;data repository;DNA Damage;Dose;Dysplasia;Enzymes;Event;exome sequencing;Gastric Adenocarcinoma;Gastric Glands;Gastric Parietal Cells;gastric tumorigenesis;gastrointestinal;Gene Expression;Gene Mutation;Generations;Genes;Genetic Models;Genomic Instability;Genomics;Glandular Cell;global health;Goals;Growth;Health;Helicobacter pylori;High Prevalence;Human;Image;Inflammation;inhibitor;Injury;innovation;Lesion;Licensing;Link;Lysosomes;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Medical;Metabolic;Metaplasia;Methylnitrosourea;Modeling;Molecular;mouse model;Mus;Mutagens;mutant;Mutant Strains Mice;Mutation;Neoplasms;neoplastic;novel;Organelles;Organoids;paligenosis;patient population;Patients;Pattern;premalignant;Procedures;Process;Production;progenitor;programs;progression risk;Proliferating;Protocols documentation;recruit;Recycling;Regulation;repaired;Resolution;Resources;response;response to injury;Role;S phase;Sampling;Signal Transduction;spasmolytic polypeptide;stem cell genes;stem cell proliferation;Stomach;Tamoxifen;Testing;Time;Tissue Microarray;Tissues;tool;TP53 gene;transcriptome;transcriptome sequencing;Translating;translational study;tumor;tumor progression;tumorigenesis;Universities;University resources;wound healing

PROJECT_TITLE: Mechanisms and biomarkers in aberrant paligenosis-induced stomach tumorigenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-M(50)R]


ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative: Although recent advances in immunotherapy, such as checkpoint blockade, have transformed the treatment of cancer, radical new approaches are needed to both improve the efficacy of existing treatments, as well as offer entirely new therapeutic modalities. We have discovered a novel mechanism for inhibiting receptor signaling by oncology targets, termed RIPR, with implications for immunotherapy of many different types of cancers.

PI_NAMEs: DOUGAN, MICHAEL LAWRENCE;GARCIA, KENAN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Affinity;Animals;antagonist;Anti-CD47;anti-PD-1;anti-PD1 antibodies;Autoimmune;Award;Back;bench to bedside;Binding;Biochemical;Biological;Bispecific Antibodies;Blocking Antibodies;cancer infiltrating T cells;cancer therapy;cancer type;CD47 gene;CD47-SIRPα;Cell surface;checkpoint inhibition;checkpoint receptors;Clinical;Clinical Trials;Collection;Colon;Colonic inflammation;Combination immunotherapy;CTLA4 gene;cytokine;Dimerization;Drug Targeting;Eating;effector T cell;efficacy evaluation;Engineering;Exhibits;extracellular;Extracellular Domain;Goals;Grant;Homeostasis;Human;Immune;immune checkpoint blockade;Immune response;Immune system;Immunologic Receptors;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;in vivo evaluation;Inflammatory;Insulin-Dependent Diabetes Mellitus;interest;Interleukin-2;ITAM;ITIM;Ligand Binding;Ligands;Ligation;Link;Macrophage;Malignant neoplasm of pancreas;MC38;Mediating;Melanoma;Modality;Modeling;Molecular;Monoclonal Antibodies;mouse model;Mus;Myelogenous;Myeloid Cells;novel;novel strategies;novel therapeutics;Oncology;Organoids;Patients;PD-1 blockade;Performance;Phosphoric Monoester Hydrolases;Phosphotransferases;Play;Production;programmed cell death ligand 1;programmed cell death protein 1;Protein Dephosphorylation;Protein Engineering;Proteins;PTPNS1 gene;PTPRC gene;receptor;Receptor Inhibition;Receptor Signaling;receptor-mediated signaling;recruit;Role;Signal Transduction;small cell lung carcinoma;Structure-Activity Relationship;synergism;System;T-Cell Activation;T-Lymphocyte;Technology;Therapeutic;Therapeutic antibodies;Toxic effect;Treatment Efficacy;tumor;Tumor Antibodies;Tumor Cell Line;Tumor Immunity;Tyrosine Phosphorylation

PROJECT_TITLE: Strategies for Receptor inhibition in immunotherapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


PI_NAMEs: VAN ZIJL, PETER CM (contact)

PROJECT_TERMS: Anatomy;Biological Markers;biomarker development;Biomedical Engineering;biomedical imaging;Book Chapters;Books;Brain imaging;Categories;Clinic;Clinical;Communication;Communities;Computer software;Data Analyses;Dedications;disease diagnosis;Educational process of instructing;Educational workshop;Electronic Mail;Goals;Hospitals;In Situ;Industry;International;Internet;Journals;lectures;Magnetic Resonance Imaging;Manufacturer;meetings;member;Metabolic;Methods;new technology;next generation;novel;Online Systems;online tutorial;Paper;Peer Review;Physiologic pulse;Physiological;Postdoctoral Fellow;program dissemination;Publications;Research;Research Personnel;Resources;Scientist;Site;Site Visit;Spectrum Analysis;Students;symposium;Techniques;Technology;technology development;Technology Transfer;tool;Training;Universities;web site;Work

PROJECT_TITLE: Training and Dissemination


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Immunotherapy;Infectious Diseases;Liver Disease

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Blockade of the T cell inhibitory receptor PD-1 has revolutionized cancer therapy and is now explored for treatment of chronic viral infection, another condition marked by exhausted immunity. In this project we will evaluate whether and how PD-1 blockade enhances immunity to hepatitis B virus (HBV) in an HBV PD-1 blockade trial. The expected results will dramatically increase our understanding of the molecular response to PD-1 blockade and thus will enable further refinement of these groundbreaking new therapies.

PI_NAMEs: CHUNG, RAYMOND T;LAUER, GEORG MICHAEL (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Advanced Malignant Neoplasm;Affect;AIDS clinical trial group;anti-PD-1;anti-PD1 therapy;Antigen Targeting;antigen-specific T cells;Antigens;Antitumor Response;Blood;cancer therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Nucleus;Cells;Cellular Immunity;Cessation of life;checkpoint therapy;Chronic;Chronic Hepatitis B;chronic infection;Clinical Trials;Data;design;digital;Disease;Epigenetic Process;exhaust;exhaustion;Fine needle aspiration biopsy;Freezing;Funding;Genetic Transcription;global health;Hepatitis B Vaccines;Hepatitis B Virus;Hepatocyte;HIV;Human;Immune;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunologics;Immunotherapeutic agent;Immunotherapy;improved;In Situ;Individual;Inflammatory;Innate Immune Response;insight;intrahepatic;laser capture microdissection;Liver;Macrophage;Mediating;Mediator;Minority;Molecular;monocyte;National Institute of Allergy and Infectious Disease;Natural Immunity;novel;novel therapeutics;Participant;pathogen;Pathway interactions;Patients;PD-1 blockade;PD-1 pathway;Peripheral Blood Mononuclear Cell;Persons;pgRNA;Phagocytes;Phenotype;Population;Population Heterogeneity;programmed cell death ligand 1;programmed cell death protein 1;receptor;Recovery;Regulation;response;Sampling;T cell response;T-Lymphocyte;Testing;Therapeutic;Tissues;Transcriptional Regulation;Treatment Failure;Treatment outcome;Viral;Viral Antigens;Viral Cancer;viral RNA;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Immunologic correlates of functional cure of HBV with immune checkpoint blockade

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-N(02)M]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PHR: CENTER OVERVIEW: PROJECT NARRATIVE Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are debilitating conditions that affect more than a million people in the United States. This proposal describes our multi-institutional, interdisciplinary Center that serves as a nexus connecting fundamental science, clinical translation, and patient benefit. Since its establishment in 1991, this Center has maintained an overall goal to promote and facilitate research that yields insight into IBD pathogenesis and leads to therapeutic advancements.

PI_NAMEs: XAVIER, RAMNIK J (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: adaptive immunity;Address;Affect;Anti-Tumor Necrosis Factor Therapy;Applied Research;Area;Atlases;Award;Basic Science;Biology;Boston;Catalogs;cell type;Cells;Chemicals;Clinical;Clinical Research;clinical translation;clinically relevant;Collaborations;Colon;Communities;Complex;Crohn's disease;Data;Data Analyses;data integration;Data Science;Development;Digestive System Disorders;Discipline;Disease;disorder risk;Educational workshop;Environment;Environmental Risk Factor;Epithelium;Etanercept;Etiology;Event;Fostering;Foundations;Functional disorder;Funding;Gastroenterology;gene function;General Hospitals;Genetic;genome repository;Goals;gut microbiome;Health;Home;host-microbe interactions;Human;Human Genetics;Human Microbiome;Immune;immune function;Immunologic Factors;Immunologist;Immunology;in vivo Model;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inhibitor;insight;Institution;International;Intestines;Investigation;Massachusetts;Measurement;Medical center;member;metabolomics;Metadata;Metagenomics;metatranscriptome;metatranscriptomics;microbial;microbiome;Molecular;Monoclonal Antibodies;Mucous Membrane;multidisciplinary;Natural Immunity;novel diagnostics;novel therapeutics;Outcome;Pathogenesis;Pathway interactions;Patients;permissiveness;Persons;Phase;Physicians;Physiological;Population;Productivity;programs;Prospective Studies;recruit;Research;Research Personnel;Research Project Grants;Resistance;Resources;Science;Scientist;senior faculty;success;Susceptibility Gene;symposium;Systems Biology;Talents;Technology;Therapeutic;TNF gene;transcriptomics;Translational Research;Treatment Protocols;treatment response;Ulcerative Colitis;United States;Visualization

PROJECT_TITLE: Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

PROJECT_TERMS: Acceleration;Achievement;Advisory Committees;Award;base;Basic Science;Cells;Clinical;clinical care;cloud based;cohort;Collaborations;Communication;Communities;convict;Cost Measures;Cost Savings;Data;Data Science;Decision Making;Development;Digestive System Disorders;Discipline;Education;Educational workshop;Effectiveness;Ensure;Environment;Feedback;Fostering;Funding;Gastroenterology;General Hospitals;Genomics;Goals;Grant;Human Genetics;Human Microbiome;Immunity;Individual;Inflammatory Bowel Diseases;Infrastructure;insight;Institution;Intestines;Israel;Leadership;Learning;Massachusetts;Medical center;medical schools;medical specialties;meetings;member;Methods;microbiome;Molecular Genetics;National Institute of Diabetes and Digestive and Kidney Diseases;news;novel therapeutic intervention;Pathogenesis;Productivity;programs;Public Health Schools;Research;Research Personnel;Resources;responsible research conduct;Scientist;Series;Structure;symposium;Techniques;Technology;Therapeutic;tool;Training;Translational Research;Universities;Visit;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: WORCESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: RNAi-related pathways have deeply conserved connections to chromatin silencing in all Eukarya and play important roles in suppressing transposons in animal genomes. Currently, RNAi is under clinical development for numerous indications, and the first RNAi drug is now approved. The genetic and biochemical studies proposed here will advance our understanding of how RNA-guided mechanisms regulate gene expression, and should also provide insights into both new applications for RNAi in probing gene function and for enhancing the therapeutic potential of RNAi drugs.

PI_NAMEs: MELLO, CRAIG C (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Animals;Biochemical;Biomedical Research;Caenorhabditis elegans;Cellular biology;Chromatin;clinical application;clinical development;cofactor;deep sequencing;Development;Developmental Biology;Double-Stranded RNA;egg;Equipment and supply inventories;Fire - disasters;Gene Expression;gene function;Gene Silencing;Generations;Genes;Genetic;Genetic Screening;Genetic Transcription;Genome;genome editing;genome-wide;Germ Lines;Guide RNA;Human;Human Biology;human disease;Human Genome;insight;Licensing;Maintenance;Mediating;Messenger RNA;Nematoda;Nucleotides;Pathway interactions;Pharmaceutical Preparations;Play;Protein Family;Proteins;Proteomics;recruit;Ribonuclease H;RNA;RNA Interference;Role;Scanning;Signal Transduction;Small RNA;sperm cell;stem cells;System;Technology;Therapeutic;tool;transgenerational epigenetic inheritance

PROJECT_TITLE: RNA Mediated Genetic Interference in C. elegans


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Lung;Pulmonary Hypertension;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Pulmonary arterial hypertension (PAH) is a progressive and currently incurable disease, affecting up to 1 in 20,000 people and leading to death in a median of six years from diagnosis despite treatment. Abnormal hemodynamic forces play a critical role in the development and progression of PAH but have been difficult to study through traditional methods. Identifying hemodynamic-sensitive pathways involved in PAH will lead to new therapeutic targets for this terrible disease.

PI_NAMEs: RAYNER, SAMUEL GIBSON (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Abnormal Cell;Address;Affect;arteriole;Basic Science;Behavior;Bioinformatics;Biomedical Engineering;Blood flow;Blood Vessels;Calcium Signaling;career development;Cells;Cellular biology;Cessation of life;Collagen;combinatorial;Communication;Complex;Coupled;Cues;Data;design;Development;Development Plans;Diagnosis;Disease;Endothelial Cells;Engineering;Environmental Risk Factor;Exposure to;Functional disorder;Future;Gene Expression Profile;Genetic Transcription;Goals;hemodynamics;Human;Immunofluorescence Immunologic;Individual;Investigation;Laboratories;Lung;Mentorship;Methods;Microfluidic Microchips;Microfluidics;Modeling;Modernization;Morphology;new therapeutic target;next generation sequencing;novel;Pathogenesis;Pathologic;Pathway interactions;Patients;Pattern;Persons;Pharmacologic Substance;Phenotype;Physicians;Physiological;Play;Positioning Attribute;precision medicine;pressure;prevent;Production;programs;Proliferating;prototype;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary artery structure;pulmonary vascular cells;Pulmonary Vascular Resistance;Research;Research Proposals;response;right ventricular failure;Role;Scientist;screening;shear stress;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skills;Smooth Muscle Myocytes;success;Techniques;Therapeutic;Therapeutic Intervention;Time;Training;transcriptome sequencing;transcriptomics;Translational Research;Vascular Diseases;Vascular remodeling;Work

PROJECT_TITLE: Hemodynamic Contributions to Vascular Dysfunction in Pulmonary Arterial Hypertension

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD);Rehabilitation

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: The proposed research is relevant to medical technology because the design and development of the proposed SWIP are expected to establish biomedical sensing instrumentation that monitors post- surgery recovery to ensure well-being, prevent adverse events, and maximize surgical outcomes. Thus, this proposal is relevant to the part of NIH vision that pertains to fostering fundamental creative discoveries, innovative research strategies, and their applications as a basis for ultimately protecting and improving health.

PI_NAMEs: BAI, WUBIN  (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Address;Adverse event;Animal Model;Arteries;base;Biocompatible Materials;biomaterial compatibility;Blood flow;blood gas analyzer;Blood Vessels;Bluetooth;Bypass;Calibration;Cellular Phone;Cessation of life;Chronic;Clinical;Clinical Research;Cloud Computing;Complex;Creativeness;Cutaneous;Data;Data Display;design;Development;Device Safety;Devices;Diagnosis;diagnostic technologies;Drug Delivery Systems;electronic sensor;Ensure;Environment;Event;fabrication;Failure;Fostering;Future;Glycolates;Goals;Health;hemodynamics;histological studies;Hour;Human Resources;Immunohistochemistry;Implant;implantation;Implantation procedure;improved;Individual;Injectable;innovation;instrumentation;Light;lithography;Location;Measurement;Medical Technology;Microfabrication;Microsurgery;Monitor;Morbidity - disease rate;multimodality;Mus;Muscle;Nature;Necrosis;Needles;next generation;novel;Operative Surgical Procedures;Optics;Pain;Pathway interactions;Patients;Performance;Personal Satisfaction;personalized medicine;Physical Examination;Physiologic Monitoring;Physiological;Physiology;Play;Polyvinyl Alcohol;porcine model;Postoperative Care;Postoperative Period;prevent;Procedures;real time monitoring;Reconstructive Surgical Procedures;Recovery;Rehabilitation therapy;remote health care;Research;Respiration;Risk;Role;Safety;Scheme;sensor technology;Series;Signal Transduction;skills;Skin;success;Surface;surgery outcome;Surgical Flaps;Surgical Management;System;Techniques;Technology;technology platform;Testing;Thrombosis;Time;tissue oxygenation;Tissues;Toxic effect;United States National Institutes of Health;Vascular blood supply;Veins;Vision;waveguide;wearable device;wearable sensor technology;wireless;wireless communication;Work;wound care;wound healing

PROJECT_TITLE: Wearable, Wireless Deep-tissue Sensing Patch for Continuous Monitoring of Recovery from Microsurgical Tissue Transfer

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ORG_DEPT: SURGERY

PHR: PUBLIC HEALTH RELEVANCE The involvement of the immune system in hypertension has been recognized for over 50-years. However, the factors responsible for the initiation of renal immune cell infiltration, and the mechanisms by which immune cells amplify the progression of hypertension, have not been fully elucidated. Better understanding of these mechanisms may unveil novel therapeutic targets and biomarkers for hypertension.

PI_NAMEs: EVANS, LOUISE CHRISTINE (contact)

PROJECT_TERMS: absorption;Acceleration;Acids;Aldosterone;antagonist;Blood Pressure;blood pressure elevation;blood pressure regulation;Cardiovascular Diseases;CCL4 gene;CCR1 gene;CCR5 gene;Cells;chemokine;chemokine receptor;Citrates;Clinical;Collagen;Dahl Hypertensive Rats;Data;Data Analyses;Development;Disease;Duct (organ) structure;Epithelial Cells;Essential Hypertension;Exposure to;fatty acid metabolism;Fibrosis;genetic association;Glomerular Filtration Rate;high salt diet;Home;Hypertension;hypertension treatment;hypertensive;Immune;immune activation;immune cell infiltrate;Immune system;in vivo;Infiltration;Inflammation;Inflammatory;Injury;Injury to Kidney;Kidney;Kidney Diseases;Left kidney;Link;Lymphocyte;Macrophage;Malignant - descriptor;Malignant Neoplasms;Metabolism;modifiable risk;Morbidity - disease rate;mortality;Nephrons;neutrophil cytosol factor 67K;new therapeutic target;novel;overexpression;Oxidative Phosphorylation;Oxidative Stress;Pathogenesis;Pathologic;Pathway interactions;Patients;Perfusion;Phase;Play;pressure;Prevalence;prevent;Production;Proteins;Proteinuria;public health relevance;RANTES;Rattus;receptor;Renal function;Renal Hypertension;Renal Tissue;Renal tubule structure;response;Right kidney;Risk Factors;Role;salt sensitive;salt sensitive hypertension;Secondary to;Sodium;Sodium Chloride;System;T-Lymphocyte;theories;therapeutic biomarker;transcriptome sequencing;transcriptomics;Tubular formation;Up-Regulation;Work

PROJECT_TITLE: Role of pressure induced renal inflammation in salt-sensitive hypertension

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Clinical Research;Data Science;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Microbiome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: DALY, MARK JOSEPH (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;Basic Science;biobank;Bioinformatics;Biological Assay;Biopsy;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collection;Communities;Complex;computational pipelines;Computer software;Computing Methodologies;computing resources;Consultations;cost effective;cost effectiveness;CRISPR screen;Data;Data Analyses;data integration;data resource;Data Science;data tools;Databases;Development;Digestive System Disorders;Dimensions;Disease;DNA;DNA sequencing;Education;Ensure;Environment;Environmental Risk Factor;Experimental Designs;Feces;follow-up;Gastrointestinal Diseases;General Hospitals;Generations;Genes;Genetic;genetic analysis;Genetic Diseases;genetic manipulation;Genetic Services;Genetic study;Genomics;Genotype;Gnotobiotic;gut bacteria;gut microbiota;Health;Human;Human Genetics;Human Microbiome;Human Resources;immune function;Immunologic Factors;In Vitro;in vivo;Individual;Inflammatory Bowel Diseases;Instruction;Internet;Investigation;Laboratories;Leadership;Libraries;Link;Massachusetts;member;Meta-Analysis;Metabolism;Metadata;Metagenomics;metatranscriptomics;Methods;microbial;microbiome;microbiome research;microbiota;Molecular Biology;mRNA Differential Displays;Mutagenesis;next generation;novel;Nucleotides;Patients;Physiology;plasmid DNA;Plasmids;Preparation;Procedures;Protocols documentation;Publications;Reagent;Recombinants;Reporter Genes;repository;Research;Research Design;Research Personnel;Research Technics;Resources;RNA;RNA Interference;Sampling;Secure;Services;Shotgun Sequencing;small hairpin RNA;Small Interfering RNA;Software Tools;System;Techniques;Technology;Technology Transfer;Therapeutic;Time;tool;Training;Training and Education;transcriptome sequencing;Viral Vector;Visualization

PROJECT_TITLE: Human Genetics and Microbiome Core


ORG_CITY: TOLEDO

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

ORG_STATE: OH

PHR: Narrative This innovative evidence-based training program will produce a number of highly-trained biomedical researchers from underserved communities who will contribute to eliminating the nation’s health disparities

PI_NAMEs: AVIDOR-REISS, TOMER ;DWORKIN, LANCE DOUGLAS;MCCULLUMSMITH, ROBERT E;OSMAN, MAHASIN A. (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Cells;Molecular;Training

PROJECT_TITLE: Training in Molecular and translational Cell Dynamics

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Clinical Research;Digestive Diseases;Genetics;Inflammatory Bowel Disease

PI_NAMEs: BROWN, DENNIS  (contact)

PROJECT_TERMS: adaptive immune response;Address;Air;Animal Genetics;Animal Model;Area;Biological;Biological Models;Biology;Categories;Cell model;Cells;Cellular biology;cellular imaging;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;Competence;Complement;Consultations;cost effectiveness;data management;Data Reporting;Development;Digestive System Disorders;Dimensions;Disease;Environment;Epithelial Cells;epithelial injury;Epithelium;Equipment;falls;Feedback;Functional disorder;Funding;gastrointestinal;General Hospitals;Generations;Genes;Genetic;genetic approach;Genetic Engineering;genetic variant;Genetic Variation;Genotype;Grant;gut inflammation;Histopathology;Human;Human Genetics;Human Resources;Image;imaging approach;Imaging technology;Immunology;improved;In Vitro;in vivo;in vivo Model;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Innate Immune Response;insight;instrumentation;intestinal homeostasis;Intestinal Mucosa;Intestines;Investigation;Laboratories;Liquid substance;Location;Massachusetts;Mediating;member;Microscope;Microscopy;model development;Modeling;monolayer;Morphology;mouse model;Mucosal Immunity;Mus;Myelogenous;nano;Nucleic Acids;Organ;organoid transplantation;Organoids;Pathogenesis;Pathologist;Pathway interactions;Phenotype;Procedures;programs;protein transport;Proteins;Protocols documentation;Publications;Quality Control;Reproducibility;Research;Research Personnel;Research Support;Resolution;Resources;response;Services;spheroids;stem cells;System;T-Lymphocyte;Targeted Research;Techniques;Technology;Time;Tissue Stains;Tissues;tool;Training;Training and Education;ultra high resolution;Visualization;Work

PROJECT_TITLE: Cellular and In Vivo Models Core


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE: Hepatic fibrosis and its end stage, cirrhosis, represent an enormous health care burden worldwide. Understanding the mechanisms of myofibroblast activation is critical for the treatment of hepatic fibrosis, and will advance the field by providing new targets for the anti-fibrotic therapy. The goal of this study is to determine the contribution of activated Portal Fibroblasts (aPFs) to the pathogenesis of cholestatic liver fibrosis in humans and mice, characterize the mechanism of their activation, and identify novel strategies for anti-fibrotic therapy with immunotoxin-conjugated anti-human MSLN Ab.

PI_NAMEs: KISSELEVA, TATIANA  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Abbreviations;Ablation;antifibrotic treatment;Area;asporin;ATAC-seq;basonuclin;Binding;CA-125 Antigen;Calcitonin;Cell Line;Cell secretion;Cells;cholangiocyte;Cholestasis;Chromatin;chronic liver disease;Cicatrix;Cirrhosis;Collagen;Collagen Type I;Complex;Consensus;Deposition;design;Development;Down-Regulation;Effectiveness;experimental study;Extracellular Matrix;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Fibroblasts;Fibrosis;Gene Expression Profile;Genes;Genetic Transcription;Goals;GPC3 gene;healthcare burden;Hepatic;Hepatic Stellate Cell;Hepatotoxicity;Human;humanized mouse;Immunoprecipitation;Immunotherapy;Immunotoxins;improved;In Vitro;in vivo;injured;Injury;insight;JAK2 gene;Kidney;knock-down;Knock-out;Label;Laboratories;Liver;Liver Fibrosis;liver injury;liver xenograft;Lung;Maps;Mass Spectrum Analysis;Mediating;Mediator;Mesenchymal;mesothelin;Modeling;Molecular;MSLN gene;Mucins;Mus;Myofibroblast;novel;novel strategies;Obstructive Liver Cirrhosis;Organ;Outcome;Paracrine Communication;Pathogenesis;Pathway interactions;Patients;Phenotype;Play;Primary biliary cirrhosis;primary sclerosing cholangitis;Property;Proteins;Recording of previous events;Regulation;response;Role;Series;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;small hairpin RNA;Sorting;Source;STAT3 gene;Stimulus;Techniques;Testing;Time;Transcriptional Regulation;transcriptome sequencing;Translating;Translational Research;Transplantation

PROJECT_TITLE: The Role of Portal Fibroblasts in Cholestatic Liver Fibrosis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition;Prevention

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative Emerging evidence suggests that a high-fat/low-fiber “Western diet” may promote Clostridioides difficile infection (CDI) through modulation of microbiome composition and activity, indicating diet modulation as a potential strategy for CDI treatment and prevention. This work will gain mechanistic insight into the relative contributions of high dietary fiber and low dietary fat in preventing antibiotic-induced gut microbiome disturbance and CDI in mice, and test a higher-fiber/lower-fat dietary intervention for prevention of C. difficile recurrence in individuals with cancer. We will also explore a novel synbiotic treatment for CDI prevention in mice, that includes probiotic treatment with bacteria adapted to a disturbed gut coupled with prebiotic treatment with gluconic acid, a substrate that these bacteria use to produce a health promoting metabolite butyrate. We hypothesize that this treatment will facilitate CDI prevention through the reestablishment of protective intestinal anaerobes in the gut microbiome.

PI_NAMEs: LOZUPONE, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Affect;Anaerobic Bacteria;Antibiotics;Apical;Bacteria;Bacterial Genes;bile acid metabolism;Bile Acids;bile salts;Butyrates;Cancer Patient;Carbon;Chemicals;Clostridium difficile;Clostridium symbiosum;cohort;Complex;Coupled;decrease resilience;Diet;dietary;Dietary Fats;Dietary Fiber;Dietary Intervention;dysbiosis;Epithelial Cells;Excretory function;Fatty acid glycerol esters;Fatty Acids;Feces;Fiber;Germination;Gluconates;Gnotobiotic;Goals;Grant;Growth;gut microbiome;gut microbiota;Health Promotion;Hematologic Neoplasms;Hematology;high risk;high-fat/low-fiber diet;Hospitalization;Hypoxia;In Vitro;Incidence;Individual;Infant;Infection;Infection prevention;insight;intestinal barrier;intestinal epithelium;intestinal hypoxia;Intestines;Lead;Link;Maintenance;Malignant Neoplasms;Metabolism;microbial;microbiome;microbiome composition;microbiota;Morbidity - disease rate;mortality;Mus;novel;novel strategies;Oncology;Oxidative Stress;Oxygen;Pathogenicity;Pathology;Patients;Pharmaceutical Preparations;Play;Population;prebiotics;Predisposition;prevent;Prevention;Prevention strategy;preventive intervention;probiotic therapy;Process;Production;Proliferating;protective effect;Recovery;Recurrence;recurrent infection;Reproduction spores;Resistance;Risk Factors;Role;saturated fat;Sodium;Source;Stem cell transplant;Taurine;Testing;Therapeutic;Toxin;Volatile Fatty Acids;western diet;Work

PROJECT_TITLE: Dietary and synbiotic strategy to limit gut microbiome dysbiosis and protect against Clostridioides difficile infection


ORG_CITY: GAINESVILLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative PUBLIC HEALTH RELEVANCE: As the majority of pharmaceutical drugs contain heterocycles, often in the form of azacycles, the ability to prepare these materials in the most rapid way possible is of the utmost importance. The broad availability of drugs is directly dependent on the existence of cost-efficient methods that can reliably build complex molecular structures. The main objective of this proposal is the development of powerful new methods and strategies for the synthesis of heterocycles, employing C–H bond functionalization and other techniques that will facilitate rapid access to valuable building blocks for the synthesis of biologically active compounds and pharmaceuticals.

PI_NAMEs: SEIDEL, DANIEL  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acids;Amines;Biological;Catalysis;catalyst;Complex;cost efficient;design;Development;drug discovery;Essential Drugs;Generations;Goals;Health;Human;Hydrogen Bonding;Libraries;Methods;Modification;Molecular Structure;Nitrogen;Oxidants;Pharmaceutical Preparations;Pharmacologic Substance;Preparation;public health relevance;Reaction;screening;Structure;Techniques;Transition Elements;Variant

PROJECT_TITLE: Development of Strategies for the Synthesis of Heterocycles

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Sepsis and septic shock are the leading causes of death in the intensive care units globally. The hyper- inflammatory phase of sepsis gives way to a hypo-inflammatory phase. It is currently difficult to distinguish the phases clinically, and we will develop markers/biomarkers to identify phases and phase-specific therapies.

PI_NAMEs: VACHHARAJANI, VIDULA  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute;Adhesions;Antibiotics;Biological Markers;biomarker identification;Cardiovascular system;Cause of Death;Cell Adhesion;Cessation of life;Chronic;Clinical;Critical Illness;Endothelial Cells;Family;Genetic;Hour;immune function;immune resistance;Immune response;Immune Tolerance;in vitro Assay;in vivo;Inflammation;Inflammatory;Inflammatory Response;Intensive Care Units;Leukocytes;Liquid substance;Metabolic;molecular targeted therapies;monocyte;mortality;Outcome;pathogen;Patient-Focused Outcomes;Patients;Peripheral Blood Mononuclear Cell;pharmacologic;Phase;Physiological;pre-clinical research;Proteins;Resistance;response;Resuscitation;Rodent;Role;secondary infection;Secondary to;Sepsis;septic patients;Septic Shock;SIRT1 gene;Sirtuins;Stimulus;Therapeutic Agents;Time;Translating

PROJECT_TITLE: Immune Function in Sepsis: Role of Sirtuin


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Public health narrative: Hepatitis B virus (HBV) remains a major health problem, globally affecting at least 257 million carriers who are at risk of developing serious liver disease, including liver cancer. Although HBV infections can be prevented through vaccination, chronic hepatitis B can rarely be cured. Here, we aim to mechanistically dissect the steps of the HBV life-cycle that are critical for persistence and could yield new targets for novel antiviral therapies.

PI_NAMEs: PLOSS, ALEXANDER  (contact)

PROJECT_TERMS: Affect;Animal Model;Anti-viral Therapy;Antibodies;Biochemical;Biological Assay;Biological Models;Cell Culture Techniques;Cell Extracts;Cell Line;Cell Nucleus;Cells;Cessation of life;Chronic;Chronic Hepatitis B;Circular DNA;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Complex;cytotoxicity;Data;design;DNA lesion;DNA Ligases;DNA Polymerase III;DNA Repair;experience;Exposure to;Generations;Genetic;Genome;Goals;Health;Hepatitis B Virus;Hepatocyte;hepatoma cell;HepG2;high risk;Homologous Gene;Human;In Vitro;Individual;Infection;innovation;Integration Host Factors;Kinetics;knock-down;Knock-out;Learning;Lesion;Life Cycle Stages;Liver;Liver diseases;Maintenance;Malignant neoplasm of liver;Mediating;Methods;Molecular;Monitor;mouse model;Mus;Mutation;Nature;new therapeutic target;novel;overexpression;Pan Genus;pathogenic virus;Patients;Persons;Physiological;Polymerase;prevent;Process;Public Health;purge;Recombinants;reconstitution;Refractory;Regimen;Relaxation;repair enzyme;repaired;replication factor C;Resolution;Risk;Role;RTH-1 Nuclease;self assembly;Series;Set protein;small hairpin RNA;System;Techniques;Testing;Therapeutic Intervention;Transcript;Vaccination;Viral;Viral Genome;Virion;Virus;Virus Diseases;Virus Receptors;Work;Yeasts

PROJECT_TITLE: Mechanisms of hepatitis B virus cccDNA formation

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease

PI_NAMEs: LUSTER, ANDREW D (contact)

PROJECT_TERMS: Autoimmunity;Award;Awareness;B-Lymphocytes;base;Bioinformatics;Biological Assay;Cell Separation;Cells;chemokine;Clinical;Clone Cells;cohesion;Collaborations;Communities;Computer Models;Consultations;cost;cost effective;CRISPR screen;cytokine;Data;Data Analyses;Data Set;design;Development;Digestive System Disorders;Disease;Education;Experimental Designs;Flow Cytometry;Fluorescent in Situ Hybridization;Fostering;Funding;Future;General Hospitals;Generations;Genomic approach;genomic profiling;Genomics;Goals;Health;Human;Human Resources;Immune;Immune system;Immunodominant Epitopes;Immunologic Monitoring;Immunologic Techniques;Immunologics;Immunology;Immunology procedure;Individual;Inflammation;Inflammation Mediators;Inflammatory Bowel Diseases;Instruction;instrument;instrumentation;Laboratories;Laboratory Personnel;Leadership;Leukocytes;Link;Massachusetts;Mediator;member;Metagenomics;Methods;Mission;Mucous Membrane;next generation sequencing;novel;Pathway interactions;Patients;Population;Production;programs;Property;Protocols documentation;Publications;Reagent;Research;Research Personnel;Resolution;Resources;RNA;Scientific Advances and Accomplishments;Services;single cell genomics;single nucleus RNA-sequencing;Spatial Distribution;Speed;System;T-Lymphocyte;Technology;Tissues;tool;Training;Training and Education;transcriptomics

PROJECT_TITLE: Cell Circuits and Immunology Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: EMERGENCY MEDICINE

PHR: Project Narrative: Ischemic stroke is a devastating neurological disease affecting millions of Americans. There is now an urgent need to develop therapeutics against stroke brain injury. This proposal will use state-of-the-art animal models, animal research infrastructure, and animal facilities to test up to eight cerebroprotective interventions for the SPAN program.

PI_NAMEs: HU, BINGREN  (contact)

PROGRAM_OFFICER_NAME: JANIS, SCOTT

PROJECT_TERMS: Address;Affect;age related;Aging;Agreement;American;Anesthesia procedures;Animal Experimentation;animal facility;Animal Model;Animals;awake;behavior test;Behavioral;Benchmarking;Biological;Blood coagulation;Blood flow;Body Weight;Brain;Brain Injuries;Caring;cerebroprotection;Cessation of life;Clinical;clinically relevant;comorbidity;Complex;Consensus;Consult;data sharing;Death Rate;Dependence;design;Diabetes Mellitus;disability;Double-Blind Method;Eating;embolic stroke;Embolism;Ensure;Equipment;experience;experimental study;Food;Funding;Guidelines;Human;Human Resources;Hyperglycemia;Hyperlipidemia;Hypertension;Hyperthermia;in vivo;Infarction;Infrastructure;innovation;Institution;instrument;Intake;Intervention;Ischemia;Ischemic Stroke;Laboratories;Laser-Doppler Flowmetry;Literature;Magnetic Resonance Imaging;Measurable;Measures;meetings;Methods;middle cerebral artery;Middle Cerebral Artery Occlusion;Modeling;Monitor;mouse model;Mus;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;novel;Obesity;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome Measure;Placebo Control;post stroke;primary outcome;Process;programs;Protocols documentation;Published Comment;Publishing;Randomized;Rattus;Recommendation;Recovery of Function;Reperfusion Therapy;Reporting;Reproducibility;Research Infrastructure;Research Personnel;Resolution;Resource Sharing;Resources;Rodent;Rodent Model;Route;Running;Schedule;sex;Site;skills;square foot;Stroke;stroke clinical trials;stroke model;Structure;Study models;Surgeon;Surgical sutures;System;Techniques;Teleconferences;Test Result;Testing;Therapeutic;Therapeutic Embolization;Time;timeline;Training;United States National Institutes of Health;ventilation;Work

PROJECT_TITLE: Testing Cerebroprotective Interventions with Rodent Ischemic Stroke Models


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Prevention;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Decades of developmental neuroscience research have illuminated multiple factors that convey risk for the development of substance use disorders (SUDs) at the group level, but the field currently lacks methods for using neurocognitive data to make accurate and generalizable predictions about SUD risk for individual youth. The proposed project seeks to address this critical gap in the field by providing an early-career scientist with the tools and training necessary to test whether the combination of two advanced computational approaches, sequential sampling models of cognitive functioning and network neuroscience methods, improve the accuracy of multivariate predictive models of individuals’ SUD risk. Knowledge from this project could lead to the development of novel computational approaches that optimize the identification of predictive features in youths’ neurocognitive data, which may ultimately inform SUD prevention efforts.

PI_NAMEs: WEIGARD, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;adolescent substance use;Adult;Advanced Development;Age;Behavior;Behavioral;Brain;Brain region;career;Clinical;Clinical Investigator;Cognition;Cognitive;cognitive development;cognitive function;Collection;computational neuroscience;Computer Models;Computing Methodologies;connectome;Data;design;Development;Diagnosis;disorder prevention;disorder risk;Early Intervention;early onset substance use;emerging adulthood;Ensure;Epidemiology;Etiology;Exclusion;externalizing behavior;feature selection;Future;Goals;Image Analysis;improved;indexing;Individual;Individual Differences;Informatics;interest;Knowledge;large datasets;Link;longitudinal dataset;Longitudinal Studies;Machine Learning;machine learning model;machine learning prediction;Measures;meetings;Mentorship;Methods;Michigan;model development;Modeling;Nervous System Disorder;neural;neural patterning;Neurocognition;Neurocognitive;neurocognitive test;neuroimaging;Neurosciences;Neurosciences Research;novel;Outcome;Parameter Estimation;patient oriented;Patients;Performance;Personality;personalized predictions;predictive modeling;predictive signature;preventive intervention;Psychologist;Psychopathology;psychosocial;Public Health;Research;Research Personnel;Research Project Grants;Resources;Rest;Risk;Risk Factors;Risk Marker;Sampling;Sampling Studies;Scientist;skills;statistics;substance use;Substance Use Disorder;Testing;theories;tool;Training;trait;Validation;Work;young adult;Youth

PROJECT_TITLE: Leveraging computational models of neurocognition to improve predictions about individual youths' risk for substance use disorders

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: FAIRBANKS

ORG_NAME: UNIVERSITY OF ALASKA FAIRBANKS

ORG_STATE: AK

PHR: Narrative: American Indian / Alaska Native students face some of the largest health disparities in the country and together with other groups, such as those from rural backgrounds are underrepresented in the biomedical research workforce. We utilize an approach that links environmental, animal, and human health under the One Health paradigm to engage students from AI/AN and rural background in meaningful research embedded in a supportive holistic mentoring system and integrated coursework to increase their participation in research education and ultimately participation in the biomedical research workforce.

PI_NAMEs: HUEFFER, KARSTEN  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Address;Alaska;Alaska Native;American Indians;Animals;Biomedical Research;career;career development;Cellular biology;Collaborations;college;Colorado;Communities;Discipline;Environment;Environmental Health;Epidemiology;experience;Family;Health;health definition;Human;Indigenous;indigenous community;Institution;Learning;Life;Life Style;Link;Measurable;Mentors;Molecular Biology;nutrition;Outcome;Population;programs;recruit;Research;Rural;rural area;student training;Students;summer research;Training Programs;Underrepresented Populations;Underrepresented Students;Universities

PROJECT_TITLE: U-RISE at the University of Alaska Fairbanks

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]