NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Sleep Research

PHR: NARRATIVE Treatment strategies for Alzheimer’s disease (AD) have been largely ineffective resulting in an increased focus on identifying effective prevention strategies. The goal of this project is to longitudinally investigate changes in 24-hour activity (sleep, physical activity, and sedentary time) with changes in cognition, structural neuroimaging, and fluid biomarkers of AD and concomitant injury prior to the onset of clinical dementia. This work will advance our understanding of how 24-hour activity behaviors contribute to AD, making a significant contribution to the field.

PI_NAMEs: FULL, KELSIE MARIE (contact)

PROJECT_TERMS: Academic Medical Centers;actigraphy;Adult;Age;Aging;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;Award;axon injury;Behavior;Behavioral;Biological Markers;Blood - brain barrier anatomy;brain magnetic resonance imaging;Cerebrospinal Fluid;Clinical;Cognition;Cognitive;cohort;Cross-Sectional Studies;Data;Dementia;dementia risk;Development;Environment;Epidemiology;Functional disorder;Goals;Growth;Hippocampus;Hour;imaging biomarker;Impaired cognition;improved;in vivo;Injury;late life;Life Style;Light;Link;Liquid substance;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Measures;Memory;Mentored Research Scientist Development Award;Mentorship;Microvascular Dysfunction;Modeling;modifiable risk;Nature;Nerve Degeneration;neurofilament;neurogranin;neuroimaging;neuroimaging marker;neuroinflammation;neuropathology;Pathologic;Pathology;Pathway interactions;Phase;Phenotype;Physical activity;Plasma;Platelet-Derived Growth Factor beta Receptor;poor sleep;Positioning Attribute;Prevention;Prevention strategy;programs;Public Health;Research;Research Activity;Research Design;Research Personnel;Risk Factors;Role;sedentary;Series;Sleep;Statistical Methods;structural imaging;Structural Models;Sum;Symptoms;Synapses;tau Proteins;tau-1;Theoretical model;Therapeutic;Time;Training;Training Activity;treatment strategy;White Matter Hyperintensity;Work

PROJECT_TITLE: The role of 24-hour activity in Alzheimer's Disease

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Nanotechnology;Prevention

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE I propose the development of a nanoparticle therapy-eluting gel that overcomes two critical challenges in myocardial drug delivery: (1) rapid diffusion away from the infarct zone due to the mechanically active heart and (2) delivery of a sustained therapeutic dosage that maintains its bioactivity. For this work, I propose the delivery of two emerging therapeutics, Anakinra, and Fresolimumab, as these two agents have been shown in clinical studies to prevent adverse remodeling of the infarct zone and would greatly benefit from controlled local delivery to avoid toxicity and off-target effects. The proposed platform is modular and can be easily tuned to deliver a range of therapeutics, allowing us to quickly adapt to new pharmacology advances and therapeutic approaches as they are developed.

PI_NAMEs: NAVARRO, RENATO SAMUEL (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Address;Affect;Aldehydes;anakinra;Anterior;Apoptosis;Arteries;Biological Assay;Biomedical Engineering;Biopolymers;Blood capillaries;Bolus Infusion;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;Catheters;Cessation of life;Chemistry;Cicatrix;Clinical;Clinical Research;clinical translation;Clinical Trials;Coculture Techniques;combinatorial;Complex;Contracts;crosslink;cytotoxic;cytotoxicity;density;design;Development;Diffusion;dosage;Dose;drug candidate;Drug Delivery Systems;Echocardiography;Elastin;Emulsions;Encapsulated;Environment;experimental group;Female;Fibroblasts;Fibrosis;Gel;Geometry;Goals;Grant;healing;Heart;Heart failure;heart function;Histologic;Hydrogels;hydrophilicity;Hydrophobicity;Impairment;improved;In Situ;In Vitro;Infarction;Inflammation;Injectable;Injections;Kinetics;Left;Ligation;Light;light scattering;lipid nanoparticle;Liquid substance;local drug delivery;male;materials science;Measurement;Mechanics;Mentors;Methods;Modality;Modeling;Modification;Molecular;Molecular Weight;mortality;multidisciplinary;Myocardial;Myocardial Infarction;Myocardial tissue;Myocardium;Myofibroblast;nanoparticle;Natural regeneration;novel therapeutics;Oils;Outcome;Output;Pain;Performance;Pharmaceutical Preparations;Pharmacology;Phase;Polymers;power analysis;pre-clinical;Pre-Clinical Model;preservation;pressure;Pressure Transducers;prevent;Prevention;Proteins;Rattus;Reaction;Rheology;Saline;Stress;Subcutaneous Injections;System;targeted delivery;Technology;Therapeutic;Therapeutic Effect;therapeutic nanoparticles;therapeutically effective;Thinness;Time;Tissues;Toxic effect;Ventricular;Water;Wistar Rats;Work

PROJECT_TITLE: Catheter-injectable system for local drug delivery after myocardial infarct


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emerging Infectious Diseases;Health Services;Immunization;Infectious Diseases;Influenza;Kidney Disease;Lung;Patient Safety;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Evidence suggests that vaccination with standard and high-dose influenza vaccines are not effective or minimally effective in preventing influenza-related outcomes in dialysis patients. Using national healthcare data on patients with end-stage renal disease undergoing dialysis in the United States, we will evaluate the utilization, effectiveness, and safety of newly licensed adjuvanted and recombinant influenza vaccines in the dialysis population. Our findings will inform dialysis patients and their providers about the risks and benefits of different vaccines and influence vaccine policy, with the ultimate goal of reducing the burden of respiratory disease in this vulnerable population.

PI_NAMEs: BUTLER, ANNE MOBLEY (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Adjuvant;Adjuvant Study;Admission activity;Adult;Adverse event;adverse event risk;Advisory Committees;Age;Antibody Response;Antigens;Baculoviruses;Benefits and Risks;Blood Chemical Analysis;Cells;Centers for Disease Control and Prevention (U.S.);Clinical effectiveness;comparative effectiveness;comparative safety;Comparative Study;compare effectiveness;Data;Databases;Dialysis patients;Dialysis procedure;Disease;Dose;Effectiveness;effectiveness analysis;effectiveness study;egg;Emergency department visit;End stage renal failure;General Population;Goals;head-to-head comparison;Health Care Costs;Healthcare;Hemodialysis;high risk population;Hospitalization;Immunization;Immunocompetence;Inactivated Vaccines;individual patient;Influenza;Influenza prevention;Influenza vaccination;influenza virus vaccine;Information Systems;Insecta;Intensive Care Units;Kidney;Licensing;Measures;Methodology;Methods;Morbidity - disease rate;mortality;novel vaccines;Outcome;Outpatients;patient population;Patients;Physicians;Pneumonia;Policies;Population;Prevention approach;Procedures;protective effect;Provider;Recombinant Vaccines;Recombinants;Recommendation;Relative Risks;Research;Research Design;Respiratory Disease;response;Risk;Safety;safety study;Scientist;seasonal influenza;Seasons;Serious Adverse Event;Severities;Severity of illness;Subgroup;System;Technology;Time;Time trend;United States;uptake;Vaccination;vaccination outcome;vaccination strategy;vaccine adverse event;Vaccine Antigen;vaccine effectiveness;vaccine evaluation;vaccine formulation;vaccine immunogenicity;vaccine safety;Vaccinee;Vaccines;Virus;Visit;Vulnerable Populations

PROJECT_TITLE: Comparative Effectiveness and Safety of Adjuvanted and Other Influenza Vaccine Technologies Among Patients Receiving Dialysis

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The recent FDA-approved Aducanumab treatment for Alzheimer’s disease (AD) demonstrated its efficacy in reducing amyloid β levels without cognitive benefits in AD patients, leaving us facing the AD crisis with no cure. This proposal will focus on a 5-HTergic circuit that undergoes permanent damages from the amyloid β depositions and accounts for memory deficits in AD pathophysiology, and evaluate the possibility of targeting this circuit to treat AD/aging-associated memory impairments in combination with the amyloid β-lowing strategy.

PI_NAMEs: LIU, HESONG  (contact)

PROGRAM_OFFICER_NAME: THOMAS, CIBU PAUL

PROJECT_TERMS: Abeta clearance;abeta deposition;Ablation;Aducanumab;aged;aging population;aging related;Agonist;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Amyloid beta-Protein;Antibodies;associated symptom;Behavior;Behavioral Symptoms;Benchmarking;Biosensor;Brain;Brain region;career;cognitive benefits;cognitive process;Combined Modality Therapy;design;Disease Progression;dorsal raphe nucleus;drug development;Drug Targeting;Electrophysiology (science);Excision;experience;experimental study;FDA approved;Fiber;Functional disorder;Functional Magnetic Resonance Imaging;Genetic;genetic approach;Hippocampus;Image;Immunohistochemistry;Impaired cognition;Impairment;improved;Knock-in;Knowledge;Lead;Learning Skill;Mediating;Memory;memory acquisition;Memory impairment;Memory Loss;memory retrieval;Modeling;Monitor;mortality;mouse model;Mus;neural circuit;neural correlate;Neurons;Neurosciences;Neurotransmitters;new therapeutic target;novel;old mice;Pharmaceutical Preparations;pharmacologic;Phase;Photometry;Physiological;Problem Solving;real time monitoring;receptor;Research;restoration;Role;Senile Plaques;Serotonin;Serotonin Agonists;skills;spatial memory;Symptoms;Synaptic plasticity;Techniques;Technology;Testing;therapeutic target;Time;tool;Training;training opportunity;Viral;Wild Type Mouse

PROJECT_TITLE: A 5-HTergic DRN vCA1 circuit and Alzheimer's disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Relevance: Most individuals exposed to cocaine and other drugs of abuse do not progress to dependence, possibly due to individual differences in sensitivity to cocaine's aversive effects, which are much less understood than its rewarding effects, but which we posit depend on specific molecular targets in the rostromedial tegmental nucleus (RMTg) that may provide novel therapeutic targets for addiction treatment.

PI_NAMEs: JHOU, THOMAS C (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: addiction;addiction liability;Addictive Behavior;Alcohol consumption;Alcohols;AMPA Receptors;Anatomy;Automobile Driving;aversive conditioning;Behavioral;Biological;Calcium;Cell Nucleus;Cocaine;cocaine exposure;cocaine seeking;Data;Dependence;Disulfiram;dopaminergic neuron;drinking;drug of abuse;Enzymes;Ethanol Metabolism;Exhibits;experience;experimental study;glutamatergic signaling;Glutamates;Habits;Individual;Individual Differences;individual variation;inhibitor;Learning;Lesion;Mediation;Midbrain structure;Molecular;Molecular Target;Motivation;neural;neuromechanism;Neurons;new therapeutic target;Nicotine;Nicotinic Receptors;non-drug;novel;optogenetics;Peptides;Permeability;Pharmaceutical Preparations;Phase;Phosphoric Monoester Hydrolases;Play;protective effect;PTEN gene;Publishing;Rattus;receptor;receptor function;Receptor Signaling;Regulation;response;Rewards;Role;Serotonin;Serotonin Receptor 5-HT2C;Signal Transduction;Smoking;Source;Specificity;targeted treatment;Testing;Therapeutic;therapeutic target;therapeutically effective;Variant;Work

PROJECT_TITLE: Neural Mechanisms of Individual Differences in Cocaine Avoidance

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Autoimmune Disease

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Th17 cells are critical for maintaining gut homeostasis, but are also implicated in certain types of autoimmunity and inflammation. This proposal’s objective is to understand the cellular metabolic pathways in Th17 cells and how changes in mitochondria, the so-called powerhouse of the cell, impact Th17 cell function, as well as function in other T cell subsets. Defining the mechanisms that regulate T cell metabolism will be critical for gaining new insights into how to therapeutically target these cells in the context of autoimmune disease, infection, and cancer.

PI_NAMEs: PEARCE, ERIKA L (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Address;Antigens;Autoimmune Diseases;Autoimmunity;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Death;Cell Differentiation process;cell growth regulation;Cell Physiology;cell type;Cells;Cellular Metabolic Process;CNS autoimmune disease;Complex;Crista ampullaris;cytokine;Data;Disease;Effector Cell;Electron Transport;Environment;environmental change;Epigenetic Process;Event;Experimental Autoimmune Encephalomyelitis;experimental study;Failure;food consumption;Generations;Genes;Genetic Transcription;Goals;Growth;gut homeostasis;Health;IL17 gene;Immune;Immune response;Immune System Diseases;Immune Targeting;Immunobiology;Impairment;In Vitro;in vivo;Infection;Inflammation;insight;Knowledge;Lead;Link;Malignant Neoplasms;Mediating;Membrane;Membrane Fusion;Memory;Metabolic;Metabolic Pathway;Metabolism;migration;Mitochondria;Mitochondrial DNA;mitochondrial membrane;mitochondrial metabolism;Monomeric GTP-Binding Proteins;Morphology;Mus;OPA1 gene;Organelles;Output;Pathology;Phenotype;Process;Production;programs;Proliferating;Protein Family;Proteins;Regulatory T-Lymphocyte;Resistance;respiratory;response;Rest;restraint;Role;Shapes;Signal Transduction;STK11 gene;Stress;Structure;T cell differentiation;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Th1 Cells;Th2 Cells;therapeutic target;transcription factor;Work

PROJECT_TITLE: Mitochondrial Membrane Dynamics in Th17 Cells

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health;Substance Misuse;Therapeutic Cannabinoid Research;Underage Drinking

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Adolescent social isolation stress coupled with alcohol drinking is a major public health problem that has been exacerbated by the current COVID-19 pandemic and can lead to lasting disruptions of brain functions. The proposed longitudinal experiments will characterize the synergistic and individual consequences of social isolation stress and alcohol exposure across the lifespan. By elucidating the endocannabinoid-related mechanisms underlying the long-term impact of social isolation stress and alcohol on adolescent and adult brain, these studies will also identify and validate potential therapeutic targets and drug candidates that can reverse and/or prevent stress and alcohol’s developmental effects on synaptic functions and behavior.

PI_NAMEs: VOZELLA, VALENTINA  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: 2-arachidonylglycerol;Abstinence;Acute;Adolescence;Adolescent;adolescent binge drinking;Adult;Affect;Aggressive behavior;Alcohol consumption;alcohol exposure;alcohol preferring rats;alcohol seeking behavior;alcohol use disorder;Alcohols;Amygdaloid structure;Anxiety;anxiety reduction;anxiety-like behavior;anxiety-related behavior;anxious;Award;Behavior;Behavior Disorders;Behavioral;Brain;Cell Nucleus;Chronic;Chronic stress;comorbidity;coping mechanism;Coupled;COVID-19 pandemic;Data;Development;Disease;Down-Regulation;drinking;drug candidate;drug reward;Drug Targeting;druggable target;Electrophysiology (science);Endocannabinoids;endogenous cannabinoid system;experience;experimental study;Female;Frequencies;Future;gamma-Aminobutyric Acid;glutamatergic signaling;Glutamates;Grouping;Human;In Situ Hybridization;Individual;insight;interdisciplinary approach;Intervention;Joints;Life;life span;Lifestyle-related condition;lipidomics;Long-Term Effects;MAGL inhibitor;male;Measures;Mediating;Modeling;Molecular;Monoacylglycerol Lipases;neuroadaptation;neurobiological mechanism;neuropsychiatric disorder;neurotransmission;new therapeutic target;peer;pharmacologic;Phenotype;Physiological;Predisposition;preference;prevent;Public Health;Rattus;Recording of previous events;reduced alcohol use;Relapse;Research;Role;sex;Sex Differences;Signal Transduction;Slice;Social Interaction;Social isolation;social stress;social stressor;Stress;Stress and Coping;stressor;Synapses;synaptic function;Synaptic Transmission;System;Testing;Therapeutic;therapeutic target;tool;Training;trait;transmission process;treatment effect;underage drinking;Vulnerable Populations;Water;Wistar Rats;Work

PROJECT_TITLE: The Role of Endocannabinoids in Adulthood Alcohol Drinking After Adolescent Social Isolation

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_CITY: WORCESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Rapid development of efficacious and safe therapies for newly-discovered disease targets is challenging. RNA therapeutics comprise a new generation of drugs that will greatly accelerate pharmaceutical development. This proposal aims to develop a programmable RNA-based therapeutic platform for silencing disease genes in the skin, opening possibilities for the treatment of a wide range of skin diseases.

PI_NAMEs: TANG, QI  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Acceleration;Acids;Affect;Alopecia Areata;Atopic Dermatitis;Autoimmune;Autoimmunity;Automobile Driving;Base Sequence;Biodistribution;Biological Products;Biological Response Modifiers;Biology;biomaterial compatibility;cell type;Cells;Characteristics;Chemical Engineering;Chemicals;Chemistry;Clinic;Clinical;clinically relevant;combinatorial;Complex;Cutaneous Lupus Erythematosus;CXCL10 gene;CXCL11 gene;CXCL9 gene;Dermatologic;Dermatology;design;Development;Disease;Dose;Drug Design;drug discovery;Drug Targeting;efficacy testing;efficacy validation;Engineering;FDA approved;Fostering;Gene Expression;Gene Silencing;Generations;Genes;Goals;Human;Hydrophobicity;IFNGR1 gene;Immune System Diseases;Immune Targeting;Immunologic Memory;Immunology;improved;in vivo;Inflammatory;insight;interest;Interferon Type II;Interleukin-15;JAK1 gene;JAK2 gene;JAK3 gene;Janus kinase;kinase inhibitor;Lead;Liver;Mentors;Messenger RNA;Metabolic;Modality;Molecular;mouse model;Mus;Nanostructures;novel;novel drug class;Nucleic Acids;Outcome;Pathology;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Population;prevent;Production;programs;Property;Proteins;Public Health;Research;RNA;RNA Interference;Rodent;Safety;scaffold;side effect;Signal Pathway;siRNA delivery;Skin;skin disorder;skin fibrosis;Small Interfering RNA;small molecule;Specificity;STAT1 gene;Structure;targeted treatment;technology platform;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapeutic RNA;therapeutic siRNA;Training;Treatment outcome;treatment strategy;TYK2;Vitiligo;Work

PROJECT_TITLE: Developing a programmable siRNA-based therapeutic platform for gene silencing in the skin

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Digestive Diseases;Emerging Infectious Diseases;Hepatitis;Infectious Diseases;Liver Disease;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Hepatitis E virus (HEV) infection causes fulminant hepatitis with high maternal and fetal mortality in pregnant women but the underlying mechanism is unknown. We will establish an in vitro placental barrier culture model that mimics the critical maternal blood- and fetal blood-facing layers in vivo to delineate the mechanisms of HEV-associated severe diseases during pregnancy. The information gained from this small R03 project will have important implications for devising effective strategies for the prevention and treatment of HEV-associated high mortality in pregnant women.

PI_NAMEs: LI, WEN  (contact);MENG, XIANG-JIN

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acute;Acute Hepatitis;Acute Liver Failure;Animal Model;Animals;Anti-viral resistance;Apical;Astrocytes;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;brain endothelial cell;CD8-Positive T-Lymphocytes;Cell Culture Techniques;Cells;Central Nervous System;Cessation of life;Clinical;Coculture Techniques;Conditioned Culture Media;cytokine;Disease;Eclampsia;Electrical Resistance;Endothelial Cells;Environment;Epidermal Growth Factor;exosome;Extracellular Matrix;Family suidae;fetal;fetal blood;fetal infection;fetal loss;Fetal Mortality Statistics;Fetus;fluorescein isothiocyanate dextran;Forskolin;Gene Expression;Gene Proteins;Genotype;Goals;Hemorrhage;Hepatitis;Hepatitis E virus;Hepatobiliary;Hepatocyte;HepG2;Human;IL18 gene;Immunoglobulin M;In Vitro;in vivo;India;Infection;Inflammatory;Interferon alpha;Interferon Type II;Interferon-beta;Interferons;Invaded;Low Birth Weight Infant;Maternal Mortality;Maternal-Fetal Exchange;Measures;Membrane;migration;Modeling;mortality;Mothers;nanoparticle;Neonatal Mortality;neutralizing antibody;Newborn Infant;occludin;particle;Permeability;Persons;Physiological;Placenta;Placenta Diseases;Predisposition;Pregnancy;Pregnant Women;Premature Birth;Prevention strategy;Production;protein biomarkers;Proteins;Reporting;Rupture;Side;small molecule;Spontaneous abortion;stillbirth;syncytin;System;T cell response;Tissues;TNF gene;transmission process;treatment group;trophoblast;Trophoblastic Cell;Umbilical vein;Vertical Transmission;Viral Load result;viral resistance;viral RNA;viral transmission;Viremia;Virion;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Placental barrier culture to delineate the mechanism of hepatitis E virus infection at the maternal and fetal interface

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VDT-Q(01)]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Nutrition;Obesity

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE: Obesity and obesity-related metabolic diseases are a growing public health concern in the United States and around the world. The pathogenesis of these diseases is driven by excess nutrient intake, and thus, identifying and characterizing metabolic pathways that can be targeted therapeutically to increase energy expenditure and dispose of excess nutrients serves an important clinical need. Focusing on lactate metabolism, my studies will improve our understanding of fuel use and metabolic flux during brown adipose tissue thermogenesis and inform future efforts targeting thermogenic adipose tissue for the treatment of obesity and obesity-related disease.

PI_NAMEs: BORNSTEIN, MARC  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acute;Adipose tissue;Adrenergic Agents;Affect;Anesthesia procedures;Automobile Driving;Award;Basic Science;Body Temperature;Brown Fat;Calories;Carbon;Cardiometabolic Disease;career;Citric Acid Cycle;Clinical;Clinical Medicine;clinical practice;clinically relevant;Consumption;Data;Development;Disease;Doctor of Medicine;Doctor of Philosophy;Energy Metabolism;Environment;Enzymes;Evolution;Exposure to;falls;Fatty acid glycerol esters;fatty acid oxidation;Feeds;Fellowship;Future;Gene Expression;Generations;Genetic Models;Glucose;Healthcare;Impairment;improved;in vivo;Infusion procedures;insight;Intake;interest;Knock-out;Knockout Mice;Label;Lactate Dehydrogenase;Learning;Mammals;Measures;Mediating;Mentorship;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Mitochondria;mitochondrial membrane;Modeling;Morbidity - disease rate;mortality;Mus;NADH;Norepinephrine;novel therapeutics;Nutrient;Obesity;Obesity associated disease;obesity treatment;optogenetics;Organ;oxidation;Oxygen Consumption;Pathogenesis;Pennsylvania;Pentobarbital;Physicians;Plasma;Play;pre-doctoral;Process;Production;programs;Protein Isoforms;Protons;Public Health;Pyruvate;pyruvate carrier;Ramp;Research;Research Personnel;response;Role;Scientist;skills;Source;stable isotope;Subcutaneous Injections;targeted treatment;Techniques;Testing;Thermogenesis;Tissues;Training;uncoupling protein 1;United States;Universities;Weight Gain;Wild Type Mouse;Work

PROJECT_TITLE: Exploring the role of lactate in adipose tissue thermogenesis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Immunotherapy;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: OTOLARYNGOLOGY

PHR: PROJECT NARRATIVE The proposed studies address the important research area of Alzheimer’s disease (AD) that is the most common form of age-associated dementia and neurodegenerative disorder, and becomes a major public health predicament. The proposed research has relevance to public health, because it seeks to dissect role of senescent T cells in the pathogenesis of AD and then to develop novel strategies to block T cell senescence for AD prevention and immunotherapy. Thus, the findings are ultimately expected to improve treatment of human AD and other neurodegenerative disorders as well.

PI_NAMEs: PENG, GUANGYONG  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acceleration;adaptive immunity;Address;Affect;age related;aged;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Area;ATM Signaling Pathway;Binding;Caregivers;CD8-Positive T-Lymphocytes;Cell Aging;Cell Physiology;Cells;Cellular Structures;Dementia;Development;Diagnostic;Disease Progression;disorder control;Distress;DNA Damage;effector T cell;Enzymes;Etiology;Exhibits;Functional disorder;Goals;Human;Immune;Immune system;Immunotherapy;improved;in vivo;Induced Neurons;Knowledge;lipid metabolism;Lipids;MAP Kinase Gene;Mediating;Metabolic;Metabolic Control;Metabolic Diseases;Modeling;Molecular;mouse model;Mus;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;novel;novel strategies;Onset of illness;Outcome Study;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathologic Processes;Patients;peripheral blood;Population;prevent;Process;programs;Public Health;Regulatory T-Lymphocyte;Research;response;Role;senescence;senescence associated secretory phenotype;Signal Transduction;T-Lymphocyte;tau Proteins;Testing;Therapeutic;therapeutically effective;Up-Regulation;Writing

PROJECT_TITLE: Metabolic Control of T Cell Senescence in Pathogenesis and Immunotherapy of Alzheimer's Disease


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pain Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Sex, Hormones and Identity affect Nociceptive Expression (SHINE) Project Narrative Sex differences in pain mechanisms and prevalence have been reported and studied to broaden our understanding of pain, but it is possible that gender identity plays a more significant role than sex assigned at birth or hormone level. Here we will collect a number of quality of life measures, measure pain sensitivity and examine immune cell populations in cisgender and transgender men and women (with/without current hormone treatment) to determine the impact of gender identity, sex assigned at birth and hormone level. The proposed study will significantly contribute to our understanding of the impact of various social and biological factors to pain expression and provide critical information with respect to the needs of this vulnerable population.

PI_NAMEs: GOODIN, BUREL R.;SORGE, ROBERT  (contact)

PROGRAM_OFFICER_NAME: WOLFF, JOSHUA R

PROJECT_TERMS: Address;adverse childhood events;Advocacy;Affect;Alabama;Appearance;Area;assigned male at birth;Biological Factors;Birth;Blood specimen;Body Image;Categories;CD8-Positive T-Lymphocytes;Cells;chronic pain;cis-female;cis-male;Communities;community advisory board;cytokine;Data;Development;Disease;Disparity;Estradiol;Estrogens;experience;Female;Frequencies;Gender;Gender Identity;Gender Role;genotypic sex;Goals;Health;Hormonal;Hormones;human subject;Immune;Immune system;Immunologics;immunoregulation;Individual;innovation;Investigation;Literature;male;man;marginalized community;Measures;men;Mental Depression;Minority Groups;Nociception;Outcome;Pain;Pain Measurement;pain sensitivity;Pain Threshold;Participant;Patient Self-Report;perceived discrimination;Personal Satisfaction;Phenotype;Play;poor health outcome;Population;Prejudice;pressure;Prevalence;Procedures;Protocols documentation;Psychological Factors;Publishing;Quality of life;Questionnaires;recruit;Reporting;reproductive hormone;Research;Risk;Role;saliva sample;Sensory;sex;sex assigned;Sex Differences;sexual identity;Sleep;sleep quality;social factors;social stigma;Social support;Standardization;Stress;stress reactivity;Testing;Testosterone;transgender;transgender men;United States National Institutes of Health;Voice Quality;Vulnerable Populations;Woman;Women's Health;Work


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Substance Misuse;Telehealth;Underage Drinking

ORG_CITY: PROVIDENCE

ORG_DEPT: PSYCHIATRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE This project will develop and pilot an innovative adaptive mobile health intervention to reduce co-use of alcohol and opioids in young adults. This intervention will have the potential to directly reduce harms related to the ongoing opioid crisis in the United States. Results will inform the design of a larger future clinical trial.

PI_NAMEs: CARPENTER, RYAN W;MIRANDA, ROBERT  (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Acceleration;acceptability and feasibility;Acute;Address;Adverse effects;Affect;Aftercare;Age;age group;aged;alcohol and other drug;Alcohol consumption;alcohol effect;Alcohols;Behavior;Cellular Phone;Cessation of life;Clinical Trials;Cognitive Therapy;Complex;Conflict (Psychology);craving;Cues;Data;design;Development;Disease;Drug usage;Ecological momentary assessment;evidence base;Evidence based practice;Feedback;follow-up;Future;Goals;Guidelines;Harm Reduction;Heroin;innovation;Intervention;intervention effect;intervention refinement;Knowledge;knowledge base;Life;Location;meetings;Metadata;mHealth;mhealth interventions;Monitor;motivational enhancement therapy;Nature;novel;Opioid;opioid epidemic;opioid overdose;opioid use disorder;overdose death;overdose risk;Pain;Participant;Patient Self-Report;Pattern;peer;Persons;prescription opioid;prevent;Public Health;Randomized;randomized, clinical trials;recruit;reduced substance use;remote assessment;Reporting;response;Risk;Sampling;skills;smartphone application;Social Environment;substance use;Technology;theories;therapy development;Time;United States;usability;Work;young adult

PROJECT_TITLE: Targeting Alcohol-Opioid Co-Use Among Young Adults Using a Novel MHealth Intervention

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PISCATAWAY

ORG_DEPT: CHEMISTRY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative: The goal of this project is to increase our structural understanding of the peripheral membrane protein Kindlin-2 and the lipid membranes to which it binds. The details of how lipids in the phosphatidylinositol phosphate family control the activity of protein binding partners, like Kindlin-2, are a major unanswered question. Solid-state NMR is a unique tool for the atomic resolution characterization of the structure and dynamics of lipids, and I plan to develop NMR experiments for directly investigating Kindlin-2-lipid interfaces with high sensitivity and specificity.

PI_NAMEs: NIEUWKOOP, ANDREW  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Affect;analog;Binding;Binding Proteins;Binding Sites;Cations;Cell Adhesion;Cell Physiology;Cellular Membrane;Charge;Chemicals;Computational Technique;Data;Dedications;design;detection of nutrient;Diabetes Mellitus;Diagnostic;dimer;Dimerization;Disease;disease-causing mutation;Environment;experience;experimental study;Family;Foundations;Goals;Grain;Growth;Health;Human;improved;Individual;inorganic phosphate;insight;Integrins;Ions;Length;Lipid Bilayers;Lipid Binding;Lipids;Liposomes;Magic;Malignant Neoplasms;Maps;Measures;Mediating;member;Membrane;Membrane Lipids;Membrane Proteins;Modernization;molecular dynamics;novel;Pathway interactions;Peripheral;PH Domain;Phosphate-Binding Proteins;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositol Phosphates;Phosphatidylinositols;Phosphoric Monoester Hydrolases;platelet protein P47;Proliferating;Property;protein complex;Protein Family;protein protein interaction;protein structure;Proteins;protonation;Protons;Regulation;Resolution;Role;Sampling;Sensitivity and Specificity;Side;Signal Transduction;simulation;Site;solid state nuclear magnetic resonance;Structure;Surface;System;Techniques;Tertiary Protein Structure;Testing;Therapeutic;timeline;tool;transmission process;Ubiquitin;Work

PROJECT_TITLE: Atomic Resolution Characterization of Kindlin-2 Binding to Phosphatidylinositol Phosphatases in Lipid Bilayers by Solid-State NMR

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: As recruitment into clinical research has been a longstanding challenge for NIH funded multi- site studies, we will Catalyze and Harmonize Operational Innovation for Recruitment (CHOIR) which will be led by a long-standing synergistic partnership between Paul Harris, PhD, as PI responsible for informatics development, and Consuelo Wilkins, MD, MSCI, as PI of community and stakeholder engagement. Formal partnerships with 10 other CTSAs provide broad understanding of Hub needs, along with key areas of expertise. We will provide a national, disease agnostic home for sharing recruitment tools, training, materials, and best practices for diverse populations.

PI_NAMEs: HARRIS, PAUL A. (contact);WILKINS, CONSUELO HOPKINS

PROGRAM_OFFICER_NAME: WILEY, KENNETH L

PROJECT_TERMS: Adopted;Area;Attention;Awareness;Benefits and Risks;Clinical Data;Clinical Research;clinical trial recruitment;Clinical Trials;Cohort Studies;Collaborations;Communities;community advisory board;community engagement;Compensation;Complex;Consultations;cost;data resource;data tools;design;Development;Disease;disenfranchised population;Disparity;Disparity population;Doctor of Philosophy;Education;electronic consent;Elements;Eligibility Determination;Enrollment;Ensure;Equity;evidence based guidelines;Fast Healthcare Interoperability Resources;Funding;Geography;Goals;health equity;Home;human disease;improved;Informatics;Informed Consent;Infrastructure;innovation;Language;Media Campaign;Methods;Minority Groups;Minority Recruitment;Mission;mobile computing;Monitor;operation;Participant;Population;Population Heterogeneity;Procedures;Recommendation;recruit;Recruitment Activity;Research;Resources;screening;Site;skill acquisition;skills;social media;success;synergism;Testing;Time;tool;Training;Translation Process;trial design;Trust;Underrepresented Populations;United States National Institutes of Health;usability;Voice;Work

PROJECT_TITLE: Catalyzing and Harmonizing Operational Innovation for Recruitment (CHOIR)


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Neurosciences;Sexually Transmitted Infections

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative Herpes simplex viruses persists for life in neurons as a latent infection and can reactivate to cause disease. The aims of this study are to understand how gene silencing occurs in neurons to impact viral gene expression and the ability of the virus to reactivate. The long-term goals are to understand how to target the latent stage of HSV infection and develop therapeutics that prevent reactivation occurring.

PI_NAMEs: CLIFFE, ANNA RUTH (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Address;Binding;Biological Assay;Biological Models;Blindness;Body Surface;Chromatin;Chromatin Structure;chronic infection;Data;Deposition;Development;Disease;Encephalitis;Epigenetic Process;Gene Expression;gene repression;Gene Silencing;Genes;Genome;genome analysis;Goals;Herpes Simplex Infections;Herpesviridae;Herpesvirus 1;Herpesvirus Type 3;Heterochromatin;Heterogeneous-Nuclear Ribonucleoprotein K;high resolution imaging;histone modification;Histones;Human Herpesvirus 2;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;latency associated transcript;latent gene expression;latent infection;latent virus activation;Latent virus infection phase;Lesion;Life;Link;Lytic;lytic gene expression;Maps;Mediating;Meningitis;Methods;Modeling;Molecular;Nervous System;Neurodegenerative Disorders;Neurons;novel;Nuclear Proteins;Pain;Pluripotent Stem Cells;Polycomb;Population;Post-Translational Protein Processing;PRC1 Protein;prevent;protein complex;Proteins;reactivation from latency;Reader;recruit;Recruitment Activity;Regulation;Repression;response;Role;Series;Simplexvirus;Stimulus;Structure;System;targeted treatment;Testing;Therapeutic;therapeutic development;therapeutic target;Untranslated RNA;Variant;Viral Genes;Viral Genome;Virus;Virus Diseases;Virus Latency

PROJECT_TITLE: Regulation of HSV latency by Polycomb Silencing

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ROOTSTOWN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTHEAST OHIO MEDICAL UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it seeks to explain how molecular events occurring in the pathway between the eye and brain may contribute to the onset and progression of dementia. This research will advance knowledge on how sensory disruptions impact the heath of the aging brain, and potentially identify new mechanistic targets for preventing onset of neurodegenerative disease, thus, supporting the missions of the NIH/NIA to promote healthy aging.

PI_NAMEs: CRISH, CHRISTINE MARIE (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: 3xTg-AD mouse;Address;Affect;age related;age related neurodegeneration;aging brain;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Amyloid;Amyloid Beta A4 Precursor Protein;Amyloid beta-Protein;Amyloid Proteins;area striata;Axonal Transport;Blindness;Brain;brain pathway;Brain region;Chemicals;Cognition;Cognitive;Data;Dementia;design;Development;Disease;Disease Progression;Early Intervention;Electrophysiology (science);entorhinal cortex;Event;Experimental Models;experimental study;Eye;falls;Foundations;Functional disorder;Future;gamma-Aminobutyric Acid;healthy aging;Hippocampus;Hyperactivity;Impaired cognition;Impairment;improved;Injections;insight;Interneurons;Intervention;Knowledge;Learning;Link;Measures;Memory;memory recognition;Methods;Mission;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurons;next generation;novel;novel therapeutic intervention;object recognition;Optic Nerve;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Play;Population;preservation;prevent;Prevention;preventive intervention;Proteins;Public Health;Qualifying;Quality of life;Research;Research Personnel;research study;resilience;response;Retina;Retinal Ganglion Cells;Role;Sensory;Sensory impairment;Sensory Process;Signal Transduction;slow potential;Source;Structure;Synapses;tau Proteins;Techniques;Testing;Transgenic Organisms;United States National Institutes of Health;Vision;Visual;visual dysfunction;Visual impairment;visual neuroscience;Visual Pathways;Visual System;Work

PROJECT_TITLE: Disruption of sensory pathways in dementia pathogenesis

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Project Narrative New American Youth on the Rise (NAYR) is a pathway program for middle and high school girls from Chittenden County Vermont immigrant communities designed to prepare students for successful transitions into college careers in health sciences. The overarching mission of NAYR is to enhance health equity for Chittenden County, Vermont immigrant communities by 1) increasing representation in the healthcare workforce that reflects their racial/ethnic backgrounds and lived experiences, and 2) increasing collaboration and trust between the academic health center and the local community by demonstrating clear investment in the local community. With a three pronged approach focusing not only on the student, but also the family and the teachers and school counselors, NAYR “cocoons” the student with mentoring activities, courses for skills development, research experience, and outreach necessary to facilitate a smooth transition into the health sciences at the college level.

PI_NAMEs: DEMING, PAULA ;DOUGHERTY, ANNE K (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Academic achievement;Academic advising;Address;Admission activity;Age;American;Award;Bachelor's Degree;boys;career;Caring;Child;cohort;Collaborations;college;Communication;Communities;Consultations;Counseling;County;Cultural Backgrounds;cultural competence;Degree Completion;Degree program;design;Development;Diagnostic;Discipline of Nursing;Dreams;Drops;Education;Educational Curriculum;Equity;ethnic disparity;Ethnic Origin;Event;experience;Family;family influence;Focus Groups;foot;Fostering;Funding;Gender;Generations;girls;Goals;Grant;Group Interviews;Habits;Health;health equity;Health Occupations;Health Personnel;Health Sciences;Healthcare;Healthcare Systems;high school;Home;Hour;Immigrant;Immigrant community;improved;Individual;interest;Investments;junior high school;Leadership;lens;Lived experience;marginalization;marginalized community;Medical;Medical center;Medicine;meetings;men;Mentors;Mentorship;Mission;Modeling;novel;Nurse Practitioners;Outcome;outreach;Parents;Participant;Pathway interactions;Patient-Focused Outcomes;Patients;Phase;Physicians;Positioning Attribute;prevent;Process;Professional counselor;Program Effectiveness;programs;Provider;Race;Request for Applications;Research;Research Personnel;Role;Running;satisfaction;School Teachers;Schools;Science;Science Enrichment;science teacher;skill acquisition;social emotional learning;social skills;Social Work;Solid;sound;Standardization;Stereotyping;Structure;student mentoring;Student recruitment;Students;success;Surveys;symposium;System;teacher;Testing;Trust;United States;Universities;Vermont;Well in self;Woman;women of color;Work;Youth

PROJECT_TITLE: New American Youth on the Rise

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (55)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Diabetes;Emerging Infectious Diseases;Infectious Diseases;Lung;Microbiome;Rare Diseases;Tuberculosis

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Accumulating evidence suggests the relationship between tuberculosis (TB) and non-communicable diseases is bidirectional, with TB disease increasing the risk of stress hyperglycemia as well as long-term adverse metabolic outcomes such as diabetes. Key knowledge gaps exist about the host responses to TB that drive cardiometabolic disease risk, limiting our ability to develop therapies and interventions to reduce non-communicable disease incidence after TB. This research project will use combined high-resolution metabolomics, high-density cytokine profiling, and measurement of lipopolysaccharide and microbial sequences in plasma of patients with TB disease across glycemic trajectories to determine (1) immunometabolic responses associated with stress hyperglycemia at TB disease diagnosis, (2) whether immunometabolic abnormalities persist after TB treatment, and (3) whether differences in the immune-microbiota interface are associated with short and long-term metabolic sequelae of TB disease.

PI_NAMEs: COLLINS, JEFFREY M (contact);MAGEE, MATTHEW JAMES;SHARMA, ASHISH ARUNKUMAR

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Acute;Address;adverse outcome;Blood Glucose;blood glucose regulation;Cardiometabolic Disease;Cardiovascular Diseases;Cells;Cessation of life;Chronic;Citric Acid Cycle;Clinical;Clinical Data;clinically significant;cohort;Country;cytokine;Data;data integration;Death Rate;density;Diabetes Mellitus;diabetes risk;Disease;disease diagnosis;disorder risk;Dyslipidemias;Enrollment;euglycemia;experience;follow-up;Funding;Future;General Population;Glucose;Glucose Intolerance;glycemic control;Glycosylated hemoglobin A;gut microbiota;Health;HIV;Hyperglycemia;Immune;immune activation;Immune response;Immune system;improved;Incidence;indexing;Inflammatory;insight;Insulin Resistance;Intervention;Knowledge;Link;Lipids;Lipopolysaccharides;Measurement;Measures;Metabolic;Metabolic Diseases;metabolome;metabolomics;microbial;microbial products;microbiome;microbiome alteration;microbiota;microbiota composition;mortality;multiple omics;National Institute of Allergy and Infectious Disease;novel therapeutics;Obesity;Outcome;Parents;Participant;Pathway interactions;Patients;peripheral blood;Permeability;Persons;Plasma;Recording of previous events;Research;Research Project Grants;Research Proposals;Resolution;response;Risk;Risk Factors;Sampling;Severity of illness;Signal Transduction;Standardization;Stress;Testing;theories;therapy development;Tissues;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;Up-Regulation;Visceral;Work

PROJECT_TITLE: Multiomics Characterization of Micobiome and Immunometabolic REmodeling in Tuberculosis Stress Hyperglycemia

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: RICHARDSON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Project Narrative Emerging ‘superbugs’, which are resistant to multiple antimicrobials, pose a daunting threat to current treatment protocols. Acinetobacter baumannii can develop multidrug resistance without acquisition of new resistance genes. Basic characterization of the underlying intrinsic resistance mechanisms will guide new antimicrobial development and improve current therapeutic treatment protocols.

PI_NAMEs: BOLL, JOSEPH MICHAEL (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Abbreviations;Acinetobacter baumannii;Affect;Anti-microbial susceptibility;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteremia;Bacterial Physiology;Biogenesis;biological adaptation to stress;carbapenem resistance;Carbapenem-resistant Acinetobacter;Carbapenems;Carboxypeptidase;cell envelope;Cell model;Cell Shape;Cell Wall;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;Colistin;colistin resistance;combat;combinatorial;Compensation;crosslink;Cytoprotection;Defect;design;Development;Enzyme Activation;Enzymes;Escherichia coli;extensive drug resistance;Fortification;Fostering;Glucosyltransferase;glycosyltransferase;Goals;Gram-Negative Bacteria;Growth;Hospitals;Human;human disease;Immunoprecipitation;improved;Infection;Intrinsic factor;Knowledge;Laboratories;Life;Link;lipooligosaccharide;Lipoproteins;Lytic;Measures;mechanical force;mechanical load;Mechanics;Membrane;Mission;Modeling;Modification;molecular modeling;Molecular Weight;Multi-Drug Resistance;Nosocomial Infections;Osmotic Shocks;pathogen;Penicillin-Binding Proteins;Peptidoglycan;Peptidyltransferase;Pharmaceutical Preparations;Phenotype;Physiology;Polymyxins;Property;Public Health;Refractory;Regimen;Regulation;Reporting;Resistance;resistance gene;resistance mechanism;response;Role;Stress;Structure;Superbug;System;Testing;Therapeutic;Treatment Failure;Treatment Protocols;treatment strategy;United States National Institutes of Health;Urinary tract;Vesicle;Work;World Health Organization;Wound Infection

PROJECT_TITLE: Mechanistic basis of how LD-transpeptidases protect against outer membranedefects

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Physical Rehabilitation;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative To address the critical unmet need for pathways to increase representation in rehabilitation health professions and creative arts therapies (RHP) research, NYU Steinhardt faculty propose to partner with College and Career Lab (CCL) in this R25 application. Our goals are: 1) To develop a novel RHP research pathway targeting middle and high school students who are most impacted by systemic inequities, building on CCL’s robust STEM- mentorship curriculum and our substantial preliminary work, 2) To design and disseminate unique science education resources by partnering with exceptional faculty and near-peer mentors at NYU Steinhardt who will provide wide ranging expertise and mentorship in state-of-the-art RHP research, 3) To leverage the study team’s strengths in education research and NYU Steinhardt’s unique partnerships with the New York City Public School system and deploy a rigorous evaluation.

PI_NAMEs: CHERNG, HUA-YU S;RAO, SMITA  (contact)

PROJECT_TERMS: Absenteeism;academic preparation;Academic support;Accreditation;Acute;Address;American;American Physical Therapy Association;Attitude;Behavioral Sciences;Biomedical Research;Black, Indigenous, People of Color;career;career preparation;Censuses;clinical practice;college;Communities;community academic partnership;community organizations;cost;Creativeness;cyber security;Data;design;Development;Disabled Persons;Discipline;Disease;Disparity;Doctor of Philosophy;Drama;Education;education research;education resources;Educational Curriculum;Educational Models;Educational process of instructing;Enrollment;Equity;ethnic minority;Ethnic Population;Evaluation;Event;evidence base;Evidence based practice;Exposure to;Faculty;Financial Hardship;Financial Support;Funding;gender minority;Goals;graduate school;Health;health disparity;Health education;Health Occupations;high school;High School Student;higher education;Human Resources;Impact evaluation;improved;Individual;Inequity;Infrastructure;innovation;junior high school;Leadership;Lesbian Gay Bisexual Transgender Queer;Literature;Low income;Manuscripts;Mentors;Mentorship;Middle School Student;Minority;Minority Groups;Mission;Music;Music Therapy;National Center for Complementary and Integrative Health;National Institute of Child Health and Human Development;Neurosciences;New York;New York City;novel;nutrition;Occupational Therapy;Outcome;Participant;Pathway interactions;peer coaching;Peer Review;physical therapist;Physical therapy;Positioning Attribute;Professional Organizations;programs;Public Health;racial minority;racial population;Rehabilitation therapy;Reporting;Research;Research Personnel;Resources;scaffold;School Teachers;Schools;Science;science education;Scientist;Self Efficacy;sexual minority;Speech-Language Pathology;Students;Subway;summer research;symposium;System;teacher;Therapeutic Studies;Time;Training;Transportation;Underrepresented Populations;United States;United States National Institutes of Health;Universities;urban area;web site;Work;Youth

PROJECT_TITLE: CCL-IGNITE (IncreasinG RepresentatioN In RehabilItation and CreaTivE Health Professions Research)


ADMINISTERING_IC: MD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Public narrative Obesity disproportionally affects racial/ethnic minorities as consequences of complicated interactions between individual behaviors (e.g., physical activities, healthy food choices) and socioeconomic and environmental context (income, public infrastructure, neighborhood green lands). However, there is no accurate measurement to assess and explore the mechanisms of obesity disparities through the utilization of infrastructures related to physical activity, healthy and unhealthy food uptake. We propose to develop and test a novel measurement tool, visitation-based obesogenic environment measurement (VOEM), as a proxy assessment of three different dimensions of obesogenic-related behaviors: physical activity, healthy food choices, and less healthy food choices at multiple geographic levels using cellphone-based place visitation data for the US.

PI_NAMEs: LI, ZHENLONG  (contact);QIAO, SHAN

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Address;Adult;adult obesity;Affect;African American population;Age;Anxiety Disorders;Area;Asian;Behavior;Behavior Therapy;Behavioral;Big Data;Black Populations;Black race;Body mass index;built environment;Calories;Cellular Phone;Censuses;Cessation of life;Communities;Consumption;Coronary heart disease;cost;County;Data;Data Analytics;Data Collection;Data Set;Decision Making;Development;Dimensions;Disparity;efficacy evaluation;Environment;ethnic minority;evidence base;Exercise;Face;fast food;Fitness Centers;Food;food resource;Geography;Green space;Health;Health behavior;Health Food;Healthcare Systems;Hispanic;Human Resources;Hypertension;Income;indexing;Individual;Infrastructure;instrument;interest;Lighting;Malignant Neoplasms;Maps;Measurement;Measures;Mental disorders;Monitor;Mood Disorders;Morbid Obesity;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;obese person;Obesity;obesity risk;obesogenic;Outcome;overweight adults;Patient Self-Report;Pattern;Performance;Persons;Physical activity;Policies;Population;Population Control;premature;Prevalence;Prevention;Proxy;Public Health;Quality of life;racial disparity;racial minority;Racial Segregation;Recreation;residence;Resource Allocation;Resources;Restaurants;Sampling;Seasons;sedentary lifestyle;Shapes;Social Desirability;social health determinants;social vulnerability;sociodemographic factors;socioeconomics;South Carolina;structural determinants;Supermarket;surveillance data;Surveys;temporal measurement;Testing;Time;tool;Transportation;trend;United States;uptake;Validation;Visit;Visualization;Vulnerable Populations;Walking

PROJECT_TITLE: Visitation-based obesogenic environment measurement: A novel instrument using Big Data approach

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Arthritis;Biotechnology;Osteoarthritis;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: Project Narrative There are currently no disease modifying osteoarthritis drugs in the clinic; drug mediated lubricin production could prevent damage and modulate inflammation. Lubricin stimulating compounds will be discovered from an FDA approved compound library in a physiologically inspired 3D human articular cartilage model. Hit compounds will be tested for efficacy in a murine non-invasive knee injury model.

PI_NAMEs: KEAN, THOMAS J. (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Affect;anterior cruciate ligament rupture;Anti-Inflammatory Agents;articular cartilage;Athletic Injuries;Biochemical;Biochemistry;Biological Assay;Cartilage;Cartilage injury;Catabolism;Cells;Chondrocytes;Clinic;clinical translation;Collaborations;Collagen Type II;cost;Data;Degenerative polyarthritis;Disease;Dose;Drug Screening;efficacy testing;Engineering;Enzyme-Linked Immunosorbent Assay;Extracellular Matrix;FDA approved;fluorophore;follow-up;gait examination;Genetic Engineering;Goals;Health Care Costs;Health Expenditures;Histology;Human;Human Engineering;In Vitro;in vitro Model;in vivo;in vivo imaging;Inflammation;Inflammation Mediators;inhibitor;Injury;Interleukin-1 beta;Intra-Articular Injections;Investigation;Joints;Knee Injuries;Lentivirus Vector;Libraries;lost earning;lubricin;Luciferases;Matrix Metalloproteinases;Mediating;Methods;Modeling;mouse model;Mus;Natural Products;new therapeutic target;novel;novel therapeutics;Operative Surgical Procedures;Outcomes Research;Pain management;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Play;Prevalence;prevent;Preventive treatment;Process;Production;programs;promoter;Property;Proteins;repaired;Reporter;Reporting;Research;response;Role;Safety;small molecule;System;Testing;three-dimensional modeling;Tissue Model;Translations;Traumatic Arthropathy;Uninsured Medical Expense;Validation;Viral;Virus Activation;Work;young adult

PROJECT_TITLE: Small molecule stimulation of lubricin for treatment of post-traumatic osteoarthritis

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Genetics;Immunotherapy

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE This project aims to uncover molecules regulating the exocytosis of cytolytic molecules from natural killer (NK) cells. The findings of this proposed research will facilitate the treatment of human diseases caused imbalances in NK cell exocytosis.

PI_NAMEs: LI, SUZHAO  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Area;Biological Assay;Candidate Disease Gene;candidate selection;candidate validation;Cell Death;Cell Line;Cell membrane;Cell Physiology;Cells;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR screen;Cytoplasmic Granules;Development;Disease;Dissection;Effector Cell;Exocytosis;Genes;Genetic;Genetic Screening;genome-wide;Glucose Transporter;GLUT 4 protein;Goals;Granzyme;Human;human disease;Immune System Diseases;immunodeficiency;immunological synapse;Immunotherapy;Individual;Infection;Innate Immune System;insight;Insulin;knockout gene;Knowledge;Lymphocyte;Lysosomes;Mammalian Cell;Mediating;Mediator;Membrane;migration;Minor;Molecular;Natural Killer Cells;neurotransmitter release;novel therapeutic intervention;novel therapeutics;organizational structure;pathogen;Pathway interactions;perforin;Physiological;Process;Proteins;receptor;Research;Serine Protease;SNAP receptor;SNAP23 gene;Synapses;syntaxin 11;Validation;VDAC1 gene;Vesicle;Work

PROJECT_TITLE: Genetic dissection of cytolytic exocytosis from natural killer cells

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Drug Abuse (NIDA only);Mental Health;Obesity;Pediatric;Prevention;Substance Misuse

ORG_CITY: LOGAN

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PHR: PROJECT NARRATIVE Impulsivity occurs when one's choices are over-influenced by immediate consequences (e.g., getting high) and under-influenced by future consequences (loss of health, wealth, and relationships). The proposed research will build on our successful experiments which illustrate a practical, low-effort method for reducing impulsivity, which is of substantial relevance to the public-health goals of the National Institute on Drug Abuse (Volkow & Baler, 2015). The findings will provide a roadmap for efficient and effective prevention research.

PI_NAMEs: MADDEN, GREGORY J (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Address;adolescent substance use;Animal Model;Behavior;Behavior monitoring;behavioral health;Child;Childhood;Choices and Control;Chronic;Clinical;clinically relevant;cognitive function;Conditioned Reflex;Conditioned Stimulus;Consumption;Decision Making;design;Dimensions;discounting;economic disparity;effective intervention;elementary school;Experimental Designs;experimental study;Fentanyl;Food;Future;Goals;Health;health goals;Heroin;HIV risk;Human;improved;Impulsivity;Individual;individual response;innovation;Intervention;kindergarten;Knowledge;Laboratories;Learning;Literature;Methods;Monitor;National Institute of Drug Abuse;Neurotic Disorders;non-drug;novel therapeutic intervention;Nursery Schools;Obesity;obesity treatment;obesogenic;Outcome;Parents;Performance;Pharmaceutical Preparations;Pharmacotherapy;Population;pre-clinical;Preparation;prevent;Prevention program;Prevention Research;Probability;programs;prolonged abstinence;Public Health;Publishing;Rattus;reinforcer;Relapse;Research;Research Design;response;Rewards;Risk Taking;Self-control as a personality trait;Services;social;Speed;substance use;Substance Use Disorder;time use;Training;Training Technics;translational potential;Translational Research;translational study;treatment trial;Vocation

PROJECT_TITLE: Pavlovian Approaches to Promoting Self-Control

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_NAME: DREXEL UNIVERSITY

PHR: Narrative While maternal substance use (SU) rates in the U.S. have quadrupled in the past decade, with significant public health consequences, mothers with substance use disorders (SUDs) remain an understudied and underserved population; for Black mothers in the U.S., the lack of research on risks, protective factors, and effective treatment elements is even more pronounced. The objectives of the proposed study are to: 1) identify the contributions of specific risk factors, including experiences of racism-related trauma, to SUD outcomes in a sample of Black mothers seeking SUD treatment; and 2) to explore whether maternal mentalizing, an established maternal SUD protective factor and buffer against the effects of trauma, may serve as a potential protective factor in this sample. Knowledge gained from the study will help clinical researchers to develop culturally responsive, evidence-based assessment tools and intervention strategies.

PI_NAMEs: CHOU, JESSICA  (contact)

PROGRAM_OFFICER_NAME: VIDAL, SARAH

PROJECT_TERMS: Accounting;Adoption;Affect;African American;Area;Assessment tool;Awareness;Behavior;Birth;Black race;black women;Buffers;Caring;Child;Child Rearing;Clinical;college;Competence;Coping Behavior;Data;Development;effective therapy;Elements;Emotions;evidence base;experience;Family;Feeling;follow-up;Fright;Future;Health;Health Care Costs;health equality;Health Promotion;high risk;improved;Intervention;intervention program;Intervention Studies;Knowledge;maternal risk;Medicine;mentalization;Mother-Child Relations;Mothers;National Institute of Drug Abuse;Outcome;Parent-Child Relations;parental role;Patients;Population;Prevention program;programs;protective factors;Public Health;racism;Recovery;Relapse;relapse risk;Research;Research Personnel;Research Priority;Risk;Risk Factors;Role;Sampling;Science;Severities;social factors;Stress;Stress and Coping;stressor;substance use;Substance Use Disorder;System;Testing;Thinking;Trauma;treatment center;Underserved Population;Universities;Woman

PROJECT_TITLE: Maternal Mentalizing as Protective Factor Against Racism-Related Trauma and Maternal Substance Use

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Fetal Tissue;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE FOXP1 is an understudied rare disease gene that is associated with a complex neurodevelopmental disorder. Cerebellar hypoplasia is a prominent feature of FOXP1 syndrome, but the cellular and molecular mechanisms driving this anomaly are unknown. We will establish the cellular and molecular distribution of FOXP1 expression in the developing cerebellum as a foundation for investigating pathological development.

PI_NAMEs: ALDINGER, KIMBERLY ANNE (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Architecture;Automobile Driving;Biological Assay;Biological Process;Blood Vessels;Body System;Brain;CD34 gene;cell type;Cells;Central Nervous System;Cerebellar vermis structure;Cerebellum;Cerebral cortex;Child;Chromatin;Clinical;Complex;Congenital cerebellar hypoplasia;Data;Data Set;Development;Diagnosis;Endothelial Cells;Environment;experimental study;fetal;fluorescence imaging;Foundations;FOXP1 gene;gene regulatory network;Genes;Genetic Predisposition to Disease;Genetic Transcription;Genomics;Goals;Health;Hematopoietic System;Hemorrhage;Heterogeneity;Heterozygote;hindbrain;Histologic;Human;Image;Individual;Infarction;Investigation;Knowledge;Lighting;Loss of Heterozygosity;Mediating;migration;Molecular;Morbidity - disease rate;Morphology;mortality;multiple omics;Mus;nerve stem cell;Neurodevelopmental Disorder;neurogenesis;Neuroglia;Neurons;neurovascular;optical imaging;Optics;Pathologic;Patients;Predisposing Factor;premature;prenatal risk factor;programs;Proteins;Radial;Rare Diseases;Regulation;Resolution;Role;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Site;Slice;spatiotemporal;Specific qualifier value;Specificity;stem cell proliferation;Syndrome;therapeutic target;Thick;Tissues;transcription factor;transcription regulatory network;two photon microscopy;Variant;Vascular Endothelial Cell;Visualization

PROJECT_TITLE: High Resolution Analysis of FOXP1 in the Developing Human Cerebellum

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-1 (01)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Narrative Eye pressure and its effect on the eye wall are among the most important factors that cause vision loss and ultimately blindness due to glaucoma. The goal of this project is to use a new technology to determine the effect of eye pressure on the eye wall and to develop sensitive new biomarkers to detect and guide treatment for glaucoma. This would allow for earlier intervention to prevent vision loss, provide future direction for developing new treatments, and aid in monitoring progression of disease.

PI_NAMEs: SAEEDI, OSAMAH JAWAID (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: 3-Dimensional;Acoustics;Address;Adoption;Adrenergic beta-Antagonists;Age;Biological Markers;biomechanical test;Biomechanics;Blindness;Blinking;Buffers;Clinical;clinical practice;Clinical Research;conjunctiva;Cornea;Cross-Sectional Studies;Data;Development;Disease;Disease Progression;Early Intervention;Elasticity;Eye;Frequencies;Future;Geometry;Glaucoma;Goals;high intraocular pressure;high risk;improved;in vivo;Investigation;Light;light scattering;Location;Longitudinal Studies;Measurement;Measures;mechanical properties;Mechanics;Methods;Microscopy;Modality;modifiable risk;Modulus;Monitor;new technology;Newly Diagnosed;Normal Range;Ocular Hypertension;Papillary;Patients;Pharmaceutical Preparations;Physiologic Intraocular Pressure;Predisposition;pressure;prevent;Primary Open Angle Glaucoma;Procedures;progression risk;Property;Reporting;Resistance;Resolution;response;Risk;Risk Factors;Risk Reduction;Sampling;Sclera;Shapes;Stress;success;Surface;Synthetic Prostaglandins;Technology;Testing;Tissues;Work

PROJECT_TITLE: Development of Robust Corneal Biomechanical Biomarkers for Glaucoma Using Brillouin Microscopy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: MADISON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE / RELEVANCE Contamination and fouling of surfaces by bacteria are critical problems in many healthcare settings and can lead to serious and substantial burdens that are costly in economic and human terms. Many materials have been designed to resist bacterial fouling, but these strategies ultimately fail when deployed in real-world scenarios. Fundamentally new approaches to the design of robust antifouling coatings that move beyond conventional materials design strategies are urgently needed and would have major and lasting impacts on human health.

PI_NAMEs: LYNN, DAVID M (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TITLE: Slippery Liquid-Infused Polymer Coatings that Release Hydrophilic Antimicrobial Agents

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_CITY: STANFORD

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The main goal of this project is to determine the existence and enzymatic activity of G4-Hemin complexes in NETs, and the biological outcomes from the free radicals generated by the DNAzyme. This project will describe of role for NETs DNA beyond simply being a scaffold to trap pathogens.

PI_NAMEs: YANG, SAMUEL  (contact)

PROJECT_TERMS: anti-microbial peptide;Antibodies;Autoantibodies;Autoimmune Diseases;Bacteria;bactericide;base;Binding;Biological;Biological Assay;Catalytic DNA;cell injury;Cells;ChIP-seq;Chromatin;Complex;COVID-19 patient;Cytoprotection;Data;DNA;Erythrocytes;Exhibits;extracellular;Feedback;Fiber;Free Radicals;G-Quartets;Gene Expression;Generations;genome-wide;Goals;Guanine;Hemin;Hemoglobin concentration result;Hemolysis;Histones;Host Defense;Human Genome;Hydrogen;Hydrogen Bonding;Hydrogen Peroxide;Hydroxyl Radical;IL8 gene;Immunity;Immunofluorescence Immunologic;Immunofluorescence Microscopy;Immunologics;Immunology procedure;In Vitro;in vivo;Individual;Inflammation;Injury;Internet;Invaded;Kinetics;Label;Measures;Monitor;multidisciplinary;neutrophil;Outcome;Oxidative Stress;pathogen;Peptides;Peroxidases;Phenotype;Physiological;Play;Post-Translational Protein Processing;Process;Promoter Regions;Proteins;Research Personnel;Resolution;response;Role;Sampling;scaffold;Structure;suicidal;Surface;Surveys;Systemic Lupus Erythematosus;Testing;Toxic effect;Transcription Initiation Site;triple helix;Visualization;Western Blotting;Whole Blood

PROJECT_TITLE: Neutrophil Extracellular Traps are Free-Radical Generating DNAzymes


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

ORG_DEPT: PATHOLOGY

PHR: Project Narrative Pre-existing immunity to one mosquito-borne flavivirus can affect the outcome of infection with other flavivirus- es in complex ways. We propose to integrate studies of human populations and non-human primate models to understand how the order in which one is infected with different flaviviruses affects the immune response and outcome of infections. Our findings will contribute to improved vaccination strategies and risk assessments of emerging flaviviruses.

PI_NAMEs: ALIOTA, MATTHEW T;FRIEDRICH, THOMAS C. (contact);HARRIS, EVA

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Address;Affect;Antibodies;Antibody Repertoire;Antibody Response;Antibody-Dependent Enhancement;Antigenic Variation;Antigens;Arboviruses;B-Lymphocytes;Binding;Biological Models;Child;Childhood;climate change;cohort;Cohort Studies;Complex;Cross Reactions;cross reactivity;Data;Dengue;Dengue Infection;Dengue Virus;design;Development;Disease;disorder risk;emerging virus;Epidemic;Epidemiology;Epitopes;experimental study;Exposure to;Fc Receptor;Flavivirus;Flavivirus Infections;Future;Geography;Human;human model;human population study;Immune;Immune response;Immunity;Immunologics;Immunology;imprint;improved;Individual;Infection;Knowledge;Licensing;Longitudinal cohort study;Macaca;Macaca mulatta;Memory B-Lymphocyte;Modeling;Monoclonal Antibodies;Mosquito Control;mosquito-borne;multidisciplinary;National Institute of Allergy and Infectious Disease;next generation;Nicaragua;nonhuman primate;Outcome;pandemic preparedness;Pathogenesis;Pathogenicity;Persons;Population;priority pathogen;Public Health;rational design;receptor function;Recording of previous events;Research Personnel;response;Risk;Risk Assessment;Risk Reduction;Sampling;Series;Serotyping;Serum;severe dengue;Shapes;Site;Specificity;Testing;translational model;transmission process;United States National Institutes of Health;Urbanization;Vaccination;vaccination strategy;vaccine-induced antibodies;Vaccines;virology;Virus;Virus Diseases;Virus Replication;Zika Virus;ZIKV disease;ZIKV infection

PROJECT_TITLE: The paradox of flavivirus antigenic non-reciprocity

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


ADMINISTERING_IC: MH

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: NARRATIVE The proposed BBQS AI Resource and Data Coordinating Center (BARD.CC) for the Brain Behavior Quantification and Synchronization (BBQS) Consortium aims to enhance neuroscience research by efficiently managing, standardizing, and sharing data from various projects. The Center will also curate relevant ML/AI models, develop a cloud-based computational platform for data analysis, and ensure efficient dissemination, training, and coordination of BBQS resources. By acting as a hub for these vital functions, the center will play a crucial role in advancing our understanding of the intricate relationships between brain activity and behavior.

PI_NAMEs: CABRERA TRUJILLO, LAURA YENISA;GHOSH, SATRAJIT SUJIT (contact);KENNEDY, DAVID NELSON

PROGRAM_OFFICER_NAME: JANES, DANIEL ERIC

PROJECT_TERMS: Acceleration;Address;Archives;Area;Artificial Intelligence;artificial intelligence model;Artificial Intelligence platform;Automation;Behavior;Behavioral;Brain;brain behavior;BRAIN initiative;Catalogs;catalyst;cloud based;Cognitive Science;Collaborations;Common Data Element;Communities;Complex;computational platform;Computer Models;computerized data processing;Computers;Data;Data Aggregation;Data Analyses;data archive;Data Coordinating Center;data curation;data ecosystem;data handling;data ingestion;data integration;data management;data modalities;data modeling;Data Set;data sharing;data standards;data submission;data visualization;Descriptor;Development;Ecosystem;Educational workshop;Electrophysiology (science);Ensure;Environment;Ethics;experience;Eye Movements;Face;Generations;Guidelines;Human;human-in-the-loop;indexing;innovation;insight;interdisciplinary collaboration;Internet;large datasets;limb movement;Link;Machine Learning;Measures;meetings;member;Mental Health;Metadata;metadata standards;Methodology;Methods;Mind;Mission;Modeling;Movement;multidisciplinary;multimodal data;neural;neuroethics;neuroimaging;neuroinformatics;Neurologic;neurophysiology;Neurosciences;Neurosciences Research;novel;online resource;Ontology;operation;Output;Performance;Peripheral;Physiology;Play;Policies;programs;public repository;quality assurance;Quality Control;Quantitative Evaluations;Research;Research Personnel;Resources;Role;Route;Scientist;sensor;Shapes;skills;Source;Standardization;Structure;System;Techniques;Temperature;Time;tool;Training;vocalization;web portal;Work;working group

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-E (02)]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Exfoliation glaucoma is an aggressive form of glaucoma carrying the high risk of blindness. This form of disease is refractory to current glaucoma therapies. The goal of our studies is to develop and test a topical drug treatment (eye drops) that inhibits the formation of exfoliation material in the eye preventing the progression of exfoliation glaucoma.

PI_NAMEs: CIOFFI, CHRISTOPHER L.;PETRUKHIN, KONSTANTIN  (contact)

PROJECT_TERMS: Address;Adrenergic beta-Antagonists;Agonist;alpha 2 agonist;analog;Applications Grants;Atrophic;Autophagosome;axonal degeneration;Biological Assay;Biological Markers;Blindness;Carbonic Anhydrase Inhibitors;Cell membrane;Characteristics;clinical development;Cornea;counterscreen;Development;Disease;disease phenotype;Dose;drug candidate;Drug Kinetics;Evaluation;Exhibits;experimental study;Extracellular Protein;Eye;Eyedrops;Functional disorder;Glaucoma;Goals;high intraocular pressure;high risk;Human;In Vitro;in vivo;Ions;kinase inhibitor;large-conductance calcium-activated potassium channels;Lead;lead optimization;Liquid substance;Lysosomes;Medical;Membrane;misfolded protein;Modeling;Mus;New Zealand;normotensive;novel;novel drug class;Open-Angle Glaucoma;Ophthalmology;Optic Atrophy;Optic Nerve;optic nerve disorder;Oryctolagus cuniculus;overexpression;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Physiologic Intraocular Pressure;Play;pre-clinical;preclinical development;prevent;Production;Prognosis;Property;protein aggregation;Refractory;Regulation;retinal ganglion cell degeneration;Rho-associated kinase;Risk Factors;Role;small molecule;Specificity;standard of care;Surface;Sympathomimetics;Synthetic Prostaglandins;System;Testing;Tissues;Topical application;Trabecular meshwork structure;trafficking

PROJECT_TITLE: Pharmacological modulation of ion currents for treatment of exfoliation glaucoma

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE One of the cardinal motor symptoms of Parkinson’s disease is bradykinesia. This proposal will determine which of two neural circuits downstream of the basal ganglia mediates the slowing of volitional actions upon the degeneration of dopamine neurons. Our findings will deepen our understanding of the pathophysiology of Parkinson’s disease and suggest novel approaches to treat its symptoms.

PI_NAMEs: KANG, UN JUNG (contact);TRITSCH, NICOLAS XAVIER

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Area;arm;arm movement;associated symptom;Axon;Back;Basal Ganglia;Behavioral;Behavioral Assay;Benchmarking;Bradykinesia;Brain;Brain region;Brain Stem;Cell Nucleus;Chronic;Clinical;cognitive ability;Development;Dopamine;dopaminergic neuron;Dyskinetic syndrome;Effectiveness;experimental study;Face;Feedback;feeding;Fiber;Forelimb;Freezing;Functional disorder;Future;Gait;Genetic Models;Goals;Hand;Image;Impaired cognition;Impairment;Infusion procedures;insight;Interphase;Investigation;Knowledge;L-DOPA induced dyskinesia;Lead;Learning;Leg;Lesion;Levodopa;Measures;median forebrain bundle;Mediating;mitopark mouse;Monitor;Motor;motor impairment;motor symptom;mouse genetics;mouse model;Movement;Mus;Nerve Degeneration;neural;neural circuit;Neurodegenerative Disorders;Neuromodulator;neuron loss;Neurons;new therapeutic target;non-motor symptom;novel;novel strategies;novel therapeutics;optogenetics;Output;Oxidopamine;Parkinson Disease;Parkinsonian Disorders;Pathway interactions;Pattern;Photometry;Physiological;posture instability;Production;Prosencephalon;Rest;restoration;Signal Pathway;Signal Transduction;Speed;Substantia nigra structure;success;symptom treatment;Symptoms;Testing;Thalamic structure;therapeutic target;therapeutically effective;Time;Tremor;Work

PROJECT_TITLE: Circuit Mechanisms of Bradykinesia in Mouse Models of Parkinson’s Disease

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: The CRE2STEM program represents a transformative change in STEM teacher education, engaging teachers from Rochester city schools, community leaders, and URMC investigators to support high school students in pursuing successful careers in science, ultimately enhancing the diverse applicant pool. CRE2STEM will transform teachers’ abilities to deliver culturally responsive STEM education with scientific evidence for contextualizing STEM education to the experiences of their students with racism, discrimination, health disparities, and lack of inclusiveness in their communities.

PI_NAMEs: CUPERTINO, ANA PAULA (contact);MARKOWITZ, DINA GROSSMAN

PROJECT_TERMS: Absenteeism;Active Learning;Address;Advisory Committees;career;Career Choice;Chronic;Cities;cohort;Collaborations;college;Communities;community collaboration;community engaged research;community partners;Competence;Consultations;Critical Thinking;curriculum development;Dedications;Development;Discrimination;diversity and equity;Drops;Education;Educational Curriculum;Educational Models;Educational process of instructing;Elements;empowerment;Ensure;equity, diversity, and inclusion;Evaluation;experience;Face;field study;Fostering;Grant;Health;health disparity;health equity;health inequalities;Health Sciences;Healthcare;high school;High School Student;implementation evaluation;insight;interest;Intervention;Knowledge;Libraries;Lived experience;mathematical learning;Motivation;Multicultural Education;multidisciplinary;Next Generation Science Standards;Performance;population health;programs;racism;Research;Research Personnel;Resources;school district;Schools;Science;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Self Efficacy;skills;STEM curriculum;STEM field;STEM program;Structural Racism;student participation;Students;summer institute;System;teacher;Teacher Professional Development;Time;tool;Translating;Trust;Underrepresented Minority;underrepresented minority student;Universities;Visit;web platform;Workforce Development

PROJECT_TITLE: Culturally Responsive Education to Enhance STEM (CRE2STEM)


ORG_CITY: PROVIDENCE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BROWN UNIVERSITY

PHR: NARRATIVE I propose to develop an experimental methodology to rationally design therapeutics for the treatment of drug- resistant bacterial infections. The goal is to design and synthesize new inhibitor compounds against an important enzyme class that confers antimicrobial resistance. Ultimately, these inhibitors will be tested for improvement in potency and spectrum of activity of known β-lactam antibiotics on clinical isolates and validated in infection models.

PI_NAMEs: NAIK, MANDAR T (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter;Active Sites;Allosteric Site;analog;anti-microbial drug;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;Bacterial Infections;bacterial resistance;beta-Lactamase;beta-Lactams;Binding;Carbapenems;Ceftazidime;Cephalosporins;Chemicals;Chemistry;Clinical;combinatorial;Combined Antibiotics;Coupled;cytotoxicity;Data;design;Development;Drug Design;drug development;drug discovery;Drug resistance;Effectiveness;Enzymes;Eukaryotic Cell;Evolution;experimental study;extensive drug resistance;functional group;Generations;Goals;Gram-Negative Bacteria;high-throughput drug screening;Horizontal Gene Transfer;Human;improved;in silico;Infection;inhibitor;Libraries;Maps;Methodology;Microbe;microbial;Microbial Biofilms;Microbiology;Modeling;Modification;NMR Spectroscopy;novel;Nuclear Magnetic Resonance;Outcome;pathogen;Pharmaceutical Chemistry;Pharmaceutical Preparations;Polymyxins;Process;programs;Proteins;Pseudomonas;Public Health;rational design;Relaxation;Relaxation Techniques;Research;Research Project Grants;Resistance;resistant strain;Resolution;Sampling;scaffold;screening;Series;Serine;Site;structural biology;Structure;success;Surface;Surveys;Systemic infection;Techniques;Testing;Therapeutic;Validation;Vertebral column;Work;World Health Organization

PROJECT_TITLE: NMR Fragment-based Design of New b-lactamase Inhibitors

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Inclusive PreK STEM Playgroups: Empowering our Youngest Learners and their  Caregivers for Confidence and Competence in STEM Learning  Project Narrative The proposed R25 Science Education Partnership Award (SEPA) is a partnership between a research institution and an informal learning space to conduct STEM focused inclusive playgroups with a goal of empowering caregivers of young children to implement high quality learning activities within their daily routines and activities. The project will examine preliminary efficacy as well as caregiver perceived changes in confidence and competence related to embedding STEM learning opportunities. Findings may be used to inform a model for inclusive STEM playgroups in informal learning spaces that has potential to be widely adopted and increase access to STEM learning, contributing to closing STEM opportunity gaps.

PI_NAMEs: AMSBARY, JESSICA A (contact)

PROJECT_TERMS: Academic skills;acceptability and feasibility;Address;Adopted;Award;Awareness;Caregivers;Child;Child Development;children's museum;Code;Collaborations;Communities;Competence;computational reasoning;Data;design;disability;early childhood;Education;empowerment;Ensure;Equity;Exhibits;Family;Feeling;Future;Goals;informal learning;innovation;Institution;Intervention;Interview;Joints;Knowledge;Learning;learning strategy;Link;Modeling;Modification;Museums;North Carolina;Outcome;Perception;Play;Preschool Child;Problem Solving;Reading;Research;Research Personnel;Resource Sharing;science education;Self Efficacy;skills;stem;Structure;Surveys;Underserved Population;Universities;Video Recording;Waiting Lists;web site;Writing

PROJECT_TITLE: INCLUSIVE PREK STEM PLAYGROUPS: EMPOWERING OUR YOUNGEST LEARNERS AND THEIR CAREGIVERS FOR CONFIDENCE AND COMPETENCE IN STEM LEARNING


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Precision Medicine;Prevention

PHR: PROJECT NARRATIVE This study will evaluate the feasibility of implementing an algorithm so that each participant in a weight loss program will receive a different sequence of financial incentives for weekly weight loss and calorie logging. In a future trial, the personalized intervention will be compared to a uniform intervention in which everyone receives the same incentive amount and timing. The personalized intervention could maximize return on investment for payers by distributing a preset budget across a population to maximize long-term, population-level weight loss in real-world settings.

PI_NAMEs: MINTZ, YONATAN  (contact);VOILS, CORRINE IONE

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Address;Adherence;adherence rate;Adult;adult obesity;Affect;Algorithms;American;arm;Behavior;Behavior Therapy;Behavioral;Benchmarking;blood pressure reduction;Body Weight decreased;Budgets;Calories;cardiovascular risk factor;Cholesterol;Clinical Trials;clinically significant;cohort;comparative efficacy;Computer software;cost effective intervention;Data;data streams;detection method;diet and exercise;dietary;digital health;Enrollment;Feasibility Studies;Feedback;financial incentive;Future;Goals;Healthcare;Heterogeneity;improved;Incentives;Individual;Infrastructure;Intervention;intervention participants;Interview;Investments;Learning;machine learning method;Maintenance;Manuals;mathematical model;Mathematics;Modeling;novel;novel strategies;Obesity;Outcome;Participant;Performance;personalized approach;personalized intervention;Persons;Population;precision medicine;Precision therapeutics;Probability;programs;prospective;Protocols documentation;Psychological reinforcement;randomized trial;response;Safety;screening;societal costs;Statistical Models;Structure;Taxes;Time;trial planning;Weight;weight loss intervention;weight loss program;Weight maintenance regimen

PROJECT_TITLE: Applying reinforcement learning to create a precision medicine weight loss intervention

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT (JA)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD)

PHR: PROJECT NARRATIVE: Though military-connected mothers experience high rates of trauma exposure and resulting mental health and parenting deficits, no culturally appropriate evidence-based interventions exist to address the associations between trauma exposure, mental health, and parenting in this population. This study adapts and preliminarily tests an innovative intervention, Parenting-STAIR (PSTAIR), which combines two existing evidence-based interventions (Skills Training in Affective and Interpersonal Regulation [STAIR] and Parenting-Child Care [PC- CARE]) to reduce mental health symptoms and improve parental functioning among trauma-exposed military- connected mothers. The adapted intervention will be brief and more targeted to the needs of individual mothers and will be further tested in a larger randomized clinical trial in a future study.

PI_NAMEs: SULLIVAN, KATHRINE  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Address;adverse outcome;Affective;Age;barrier to care;Behavior Therapy;Child;Child Care;Child Mental Health;Child Rearing;Child Welfare;childhood adversity;Client;Clinical Trials;Communities;community based treatment;comorbid depression;Control Groups;culturally appropriate intervention;Data;Data Collection;Department of Defense;design;Dropout;Elements;emotion dysregulation;evidence base;Evidence based intervention;Evidence based treatment;experience;Exposure to;Family;Family Violence;Female;Focus Groups;Foundations;Funding;Future;Healthcare Systems;heuristics;implementation outcomes;improved;improved outcome;in vivo;Individual;individualized medicine;informant;information gathering;innovation;Institute of Medicine (U.S.);intergenerational;Interruption;Intervention;Interview;Investigational Therapies;Life Cycle Stages;male;maltreatment;Mediator;Mental Health;Methodology;military family;Military Personnel;military trauma;Mothers;National Institute of Child Health and Human Development;novel;novel strategies;Outcome;parenting intervention;Parents;Participant;personalized intervention;Phase;Population;Post-Traumatic Stress Disorders;post-traumatic symptoms;prevent;Proctor framework;programs;Randomized;randomized, clinical trials;Randomized, Controlled Trials;reduce symptoms;Regulation;Research;response;service member;shared decision making;skill acquisition;skills;skills training;social stigma;Spouses;success;Symptoms;System;Taxonomy;Testing;Trauma;trauma exposure;trauma symptom;treatment as usual;treatment response;uptake;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children