ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Obesity is a common, serious, and costly chronic disease. This proposal will focus on a novel brain region and its possible role in regulating body weight balance, which may identify a novel neural target for obesity treatment.

PI_NAMEs: FANG, XING  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: addiction;Adolescent;Adult;aged;Alzheimer's Disease;Anatomy;Anterior Hypothalamus;Appetite Stimulants;Area;Bipolar Disorder;blood glucose regulation;Body Weight;Brain region;Buffers;Calories;Central Nervous System;Child;Chondroitin Sulfate Proteoglycan;Chronic;Chronic Disease;Classification;Consumption;cost;Dendrites;Digestion;Disease;Eating;energy balance;Equilibrium;Expenditure;experimental study;Extracellular Matrix;Extracellular Structure;Fatty acid glycerol esters;Feeding behaviors;Functional disorder;gain of function;Genetic;High Fat Diet;Homeostasis;Hyperphagia;Hypothalamic structure;Ions;Location;loss of function;Medical Care Costs;Metabolic;Metabolism;Methods;Modeling;Mus;National Health and Nutrition Examination Survey;neural;Neurobiology;neuronal excitability;Neurons;new therapeutic target;novel;Obesity;obesity prevention;obesity treatment;Overweight;paraventricular nucleus;Persons;pharmacologic;Pilot Projects;Play;Policies;Prevalence;prevent;prevent pandemics;Regulation;Reporting;Role;Schizophrenia;Shapes;Signal Transduction;Synapses;Synaptic plasticity;Testing;United States;Weight Gain

PROJECT_TITLE: PERIFORNICAL AREA OF THE ANTERIOR HYPOTHALAMUS REGULATES METABOLIC BALANCE

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


ADMINISTERING_IC: CE

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: Chicago

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE This study will test the feasibility, acceptability, and efficacy of a novel peer harm reduction champion intervention to reduce overdose risk among older Black adults who use opioids. This intervention is designed to both improve access to harm reduction tools and services and to reduce stigma and increase social support. If successful, this intervention will significantly reduce opioid overdose rates among a marginalized population at high risk of overdose.

PI_NAMEs: WILLIAMS, LESLIE DENISE (contact)

PROJECT_TITLE: CE24-013 - Reducing Overdose and Substance Use-related Stigma on Chicago's West Side by Training Non-substance-using Friends and Family Members of People who Use Opioids to Be Harm Reduction Champions

STUDY_SECTION_NAME: Special Emphasis Panel[ZCE1 AW (03)]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Narrative Liver cancer is one the most prevalent type of cancer with deadly outcome in the U.S. and worldwide. Liver- directed therapies such as transarterial chemoembolization or radioembolization can locally target liver lesions with low systemic toxicity, but are currently limited by the lack of precise, individualized, and reliable treatment planning tools. This work develops liver transarterial embolization treatment planning based on clinical imaging and computational methods to improve patient outcome through better selection, greater efficacy and safety.

PI_NAMEs: RONCALI, EMILIE  (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: 90Y;Acceleration;Address;Advanced Malignant Neoplasm;Aftercare;Algorithms;Anatomy;Angiography;Arterial Embolization;Artificial Intelligence;Blood Circulation;Blood flow;Blood Vessels;cancer therapy;cancer type;Chemoembolization;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical imaging;Clinical Trials;Colon Carcinoma;Complex;Computer Assisted;Computer Simulation;computerized tools;Computing Methodologies;cone-beam computed tomography;contrast enhanced computed tomography;deep learning;Development;digital twin;dosage;Dose;Foundations;Future;generative adversarial network;Goals;Grant;hemodynamics;Hepatic artery;Hepatotoxicity;Image;image guided;imaging modality;Imaging Techniques;improved;in silico;in vivo;Incidence;individualized medicine;Injections;Intervention;Interventional radiology;Learning;Lesion;Liquid substance;Liver;Liver diseases;Location;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Metastatic Neoplasm to the Liver;Methods;microsphere delivery;Microspheres;Modeling;mortality;neuroendocrine cancer;novel;optimal treatments;Outcome;Patient-Focused Outcomes;Patients;Perfusion;personalized cancer therapy;personalized care;personalized medicine;Pharmaceutical Preparations;Phase;Physicians;Physics;Portal vein structure;Positron-Emission Tomography;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;prototype;Radiation;Radiation Dose Unit;Radiation therapy;Radioembolization;Research;research clinical testing;Residual state;Resolution;Rest;Safety;Sampling;Selection for Treatments;simulation;standard of care;systemic toxicity;therapy design;Time;Tissues;tool;Toxic effect;treatment optimization;treatment planning;treatment strategy;tumor;tumor vascular supply;Validation;validation studies;Vascular blood supply;virtual;Work;X-Ray Computed Tomography

PROJECT_TITLE: A liver digital twin for personalized cancer therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-9 (M1)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Radiation Oncology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE (From Parent Grant Application) Because blood cancers are exquisitely sensitive to radiation, targeted radiation delivery via radioimmunotherapy (radionuclides stably linked to target-specific antibodies) has gained interest with a commensurate increase in radioimmunotherapy clinical trials. Although clinical efficacy has been observed in stand-alone radioimmunotherapy for cancers, or as part of conditioning regimens prior to allogeneic hematopoietic stem cell transplantation, how the normal bone marrow niche differentially responds radioimmunotherapy compared to conventional approaches is not well-understood, limiting potential interventions to mitigate the negative effects from radiation to the marrow. This proposal will address current limitations and identify how to modulate specific bone marrow niche alterations for desired clinical goals by identifying how the hematopoietic stem cells, vascular endothelial cells and stromal cells in the bone marrow niche respond to radioimmunotherapy with an alpha- emitter (astatine-211), beta-emitter (yttrium-90), or X-ray radiation, as gauged by stem cell functional assays, architecture restructuring using microscopy, and differential gene expression from RNA sequence analysis.

PI_NAMEs: OROZCO, JOHNNIE JOSE (contact);TERMINI, CHRISTINA MARIE

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: 3-Dimensional;90Y;Acceleration;Address;Adolescent;Aftercare;Allogenic;Antibodies;Apoptosis;Applications Grants;Architecture;Astatine;Bioinformatics;Biological Assay;Blood;Blood Platelets;Blood Vessels;Bone Marrow;Bone Marrow Stem Cell Transplantation;Cancer Patient;cancer radioimmunotherapy;CASP3 gene;cell behavior;Cell Compartmentation;Cell Death;Cell Line;Cell Physiology;Cell Proliferation;cell regeneration;Cell Survival;Cells;Cessation of life;Characteristics;Chemotherapy and/or radiation;Clinical;clinical efficacy;Clinical Trials;Coculture Techniques;conditioning;confocal imaging;Coupled;culture plates;Endothelial Cells;Erythrocytes;experimental study;Femur;Flow Cytometry;Fluorescence-Activated Cell Sorting;Frequencies;Future;gain of function;Gene set enrichment analysis;Genetic Fingerprintings;Genetic Transcription;Genomics;Goals;Harvest;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hour;Human;Immunoglobulin G;In Vitro;in vivo;interest;Intervention;Investigation;irradiation;Knowledge;Length;leukemia;Leukocytes;Link;loss of function;Malignant Neoplasms;Marrow;Measurement;Microscopy;MLL gene;Modeling;Molecular;monolayer;mouse model;Mus;novel;Outcome;parent grant;Pathway interactions;Patients;Population;programs;Proliferating;Provider;PTPRC gene;Radiation;radiation delivery;radiation effect;Radiation Injuries;Radioimmunotherapy;Radioisotopes;Radiolabeled;Recovery;Regimen;Regulation;Reporting;Residual state;response;Risk;RNA;RNA Sequence Analysis;Roentgen Rays;self renewing cell;Short Tandem Repeat;Signal Transduction;Stains;stem cells;Stromal Cells;Structure;Supporting Cell;Surface;System;Techniques;Technology;Therapeutic;Thick;tissue culture;Tissue-Specific Gene Expression;Tissues;tool;Toxic effect;Traction;translational potential;Transplantation;Vascular Endothelial Cell;Vascular regeneration;Whole-Body Irradiation;Work;young adult

PROJECT_TITLE: Selective Radionuclide Delivery for Precise Bone Marrow Niche Alterations - Admin Supplement


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Drug Abuse (NIDA only);Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Narra�ve: The integration of our novel experimental and computational frameworks promises not only to elucidate the role of biomolecular condensates in olfactory receptor gene regulation, but also to provide a fundamental new framework for studying biomolecular condensates. The anticipated outcomes will significantly impact our understanding of how gene expression is regulated and has the potential to transform our approach to studying biomolecular condensates and related regulatory mechanisms across a broad range of biological systems.

PI_NAMEs: GUTTMAN, MITCHELL  (contact);LOMVARDAS, STAVROS ;MA, JIAN

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: 3-Dimensional;Address;Affinity;Bar Codes;Binding;Biological;biological systems;Cell Nucleus;Cells;combinatorial;Computational Biology;computer framework;Data;Diffusion;DNA;DNA Binding;Enhancers;Ensure;Funding;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic regulatory protein;Genetic Transcription;Genome;Genomic DNA;Genomics;Grant;Individual;insight;interdisciplinary collaboration;Learning;Machine Learning;machine learning algorithm;Maps;Measurement;Measures;Messenger RNA;Methods;Modeling;Molecular;Neural Network Simulation;Neurons;Neurosciences;novel;Nuclear;Olfactory Pathways;olfactory receptor;Outcome;Physical condensation;Positioning Attribute;Process;Property;Proteins;receptor;receptor expression;Receptor Gene;Regulation;Research;RNA;Role;stoichiometry;Structure;systems research;Testing;tool;Work

PROJECT_TITLE: Three-dimensional mapping and modeling of combinatorial interactions underlying biomolecular condensates in olfactory neurons

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-L (96)]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Kidney Disease;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE  Persons with chronic kidney disease (CKD) are at high risk of fracture; however, medical management requires knowing the underlying bone turnover rate, which currently requires invasive, painful, expensive, and inaccessible bone biopsy and histomorphometry. We propose an imaging-based non-invasive ‘virtual bone biopsy’, which applies time-lapse high resolution quantitative computed tomography (HR-pQCT) to identify and quantify specific areas of new bone formation and resorption throughout a volume of bone over time. We aim to validate a novel metric of bone turnover measured by time-lapse HR-pQCT vs. the gold-standard bone turnover measured by bone biopsy, determine the sensitivity and specificity of time-lapse HR-pQCT for assessment of turnover in a CKD population, and determine whether time-lapse HR-pQCT can detect responses to therapy over time in CKD patients.

PI_NAMEs: IX, JOACHIM H;KAZAKIA, GALATEIA J (contact);NICKOLAS, THOMAS L.

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Agreement;Alkaline Phosphatase;American;Anabolic Agents;Area;Biological Markers;Biopsy;bisphosphonate;Blood;blood-based biomarker;bone;Bone Density;Bone Diseases;bone imaging;bone mass;bone quality;Bone Resorption;bone turnover;Characteristics;Chronic Kidney Failure;Classification;Clinical;clinical care;clinical practice;Clinical Trials;Complex;cortical bone;Data;design;Diagnosis;diagnostic accuracy;Diagnostic Procedure;Diagnostic tests;Disease;Dissociation;Dual-Energy X-Ray Absorptiometry;FDA approved;Forteo;Fracture;fracture risk;General Population;Health Care Costs;high risk;Hip Fractures;human old age (65+);Image;image registration;Imaging Device;imaging modality;improved;individual patient;innovation;insight;interest;Kidney;kidney dysfunction;Label;Low Dose Radiation;Measurement;Measures;Medical;meter;Methods;Monitor;Morbidity - disease rate;mortality;novel;Operative Surgical Procedures;Osteogenesis;Pain;Pathology;Patients;Peripheral;Persons;Pharmaceutical Preparations;Population;Predictive Value;prevent;Process;PTH gene;Radial;Recommendation;Reproducibility;Resolution;response;Risk Factors;Sensitivity and Specificity;Severity of illness;Structure;substantia spongiosa;targeted treatment;Testing;Tetracyclines;Three-Dimensional Image;Time;tool;treatment as usual;treatment response;Uremia;virtual;virtual biopsy;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: NonInvasive Virtual Biopsy for Determining Bone Turnover in Chronic Kidney Disease

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: MILWAUKEE

ORG_NAME: MARQUETTE UNIVERSITY

ORG_STATE: WI

PHR: PROJECT NARRATIVE Disorders of motivated behavior, such as depression and drug addiction, can be triggered or aggravated by negative experiences. This project will investigate the motivational properties of aversive stimuli and the underlying neurobiological mechanisms. Specifically, the proposed experiments aim to uncover the role of dopamine in mediating aversion-induced changes in drug seeking, negative reinforcement, and punishment learning after chronic stress.

PI_NAMEs: GRAFELMAN, ELAINE  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Acute;acute stress;Adult;Affect;Affective;American;Animals;Aversive Stimulus;Behavior;Behavioral;behavioral response;Brain;Cells;Chronic;Chronic stress;clinically relevant;Cocaine;cocaine seeking;Consumption;Data;Decision Making;Disease;Dopamine;Drug Addiction;Drug Use Disorder;Educational process of instructing;Emotional;experience;experimental study;Exposure to;Fellowship;Fiber;Genetic;Goals;illicit drug use;In Vitro;in vivo;Institution;Knowledge;Learning;Link;Measurement;Measures;Mediating;Mental Depression;Mentorship;Mood Disorders;motivated behavior;Motivation;Negative Reinforcements;neurobiological mechanism;neuromechanism;Neurons;Noise;Nucleus Accumbens;optogenetics;Outcome;Pattern;Pharmaceutical Preparations;Photometry;Positioning Attribute;Postdoctoral Fellow;Process;programs;Property;Punishment;Rattus;Regulation;Relapse;Research;response;Rewards;Role;Self Administration;Signal Pathway;Signal Transduction;skills;Stimulus;Stress;stressor;Substance abuse problem;Technology;Testing;Training;Ventral Tegmental Area

PROJECT_TITLE: Dopaminergic regulation of aversion-motivated behaviors


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Pancreatic cancer is characterized by a hypoxic microenvironment and a dense, desmoplastic stroma which is mainly composed of fibroblasts and extracellular matrix. The goal of this proposal is to elucidate the mechanisms by which hypoxia regulates bidirectional interactions between cancer cells and fibroblasts in pancreatic cancer. My studies will provide new insights into the impact of hypoxia on tumor-stroma crosstalk in pancreatic cancer, which can be exploited to devise new stroma-targeting approaches for this disease.

PI_NAMEs: NGODUP, TENZIN  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: 3-Dimensional;Accounting;Area;Blood Vessels;cancer cell;Cancer Control;cancer therapy;Cells;Coculture Techniques;cytokine;Data;density;design;Desmoplastic;Diagnosis;Disease;Extracellular Matrix;Fibroblasts;genetic signature;Goals;Human;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;Immune;in vivo;Incidence;Inflammatory;insight;Interleukin-1;Knock-out;Link;M cell;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;Molecular;mortality;mouse model;Mus;Mutation;neoplastic cell;normoxia;novel therapeutic intervention;Oxygen;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic tumorigenesis;Pathway interactions;Patients;Play;Production;Proteins;Regulation;Resistance;response;Role;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stromal Cells;System;Testing;Therapeutic;therapy resistant;Tissues;tumor;tumor hypoxia;tumor initiation;tumor microenvironment;tumorigenesis;Wit;Work

PROJECT_TITLE: Role of hypoxia in fibroblast reprogramming in pancreatic cancer


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

PHR: PROJECT NARRATIVE Small-molecule mimics of cyclic GMP-AMP (cGAMP) are a promising new class of immunotherapeutics for the treatment of cancer. Preparation of these drugs is limited, however, by the exceptionally difficulty of their prepa- ration by classic synthetic means. This proposal aims to develop highly direct biocatalytic approaches for the synthesis of cGAMP-mimics, which will enable the rapid preparation of large libraries of novel cancer therapeutic drug targets.

PI_NAMEs: MEYER, COLE CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Address;American;analog;Antineoplastic Agents;cancer immunotherapeutics;cancer therapy;catalyst;Chemicals;Clinical;clinical candidate;Clinical Trials;Communities;Complex;Constitution;cost;Cyclic GMP;Data;Development;Dinucleoside Phosphates;Drug Compounding;drug efficacy;Drug Targeting;Eating;Engineering;Enzymes;Fellowship;Friends;Generations;Health;high throughput screening;Homologous Gene;Human;Hydroxyl Radical;Immunotherapeutic agent;improved;inorganic phosphate;insight;Investigation;Isomerism;Knowledge;Libraries;Malignant Neoplasms;manufacture;Methodology;Methods;Modification;Nature;non-Native;novel;novel therapeutics;nucleobase;Nucleosides;Periodicity;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phosphorothioate;Phosphorus;Preparation;Process;Protein Engineering;Proteins;Reference Standards;Reporting;Research;Route;Scientist;screening;Site;small molecule;statistics;STING agonists;Structure;Technology;Therapeutic;Variant;Vertebral column;Work

PROJECT_TITLE: Development of a Biocatalytic Toolbox for the Synthesis of Small-Molecule Mimics of cyclic GMPAMP


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Precision Medicine;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Mechanisms of residual cell survival following initial therapy, one of the leading causes of cancer recurrence, remain under-studied, in part due to the scarcity of tools and models to faithfully study the evolutionary dynamics of residual disease. My doctoral work will focus on designing novel imaging methodologies to visualize spatiotemporal metabolic and vascular heterogeneities during residual disease and recurrence in vivo while my postdoctoral work will focus on elucidating the molecular mechanisms that drive recurrence using faithful PDX models of triple negative breast cancer to identify actionable metabolic and vascular targets. This synergistic approach will provide a holistic understanding of the behaviors of residual tumors, guiding the development of targeted therapies aimed at eradicating residual disease to reduce or delay recurrence.

PI_NAMEs: SUNASSEE, ENAKSHI D. (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Aftercare;Anatomy;anti-cancer research;Award;Behavior;Biological Assay;Blood capillaries;Blood Vessels;Breast Cancer Model;Cancer Biology;cancer cell;Cancer Etiology;cancer recurrence;Cause of Death;Cell Survival;Cells;Characteristics;chemotherapy;Clinical;clinically relevant;Complement;Crowding;design;Development;Diameter;Disease regression;Doctor of Philosophy;Environmental Risk Factor;Exhibits;fatty acid oxidation;Fatty Acids;Functional Imaging;Gene Expression Profiling;Genetic Transcription;Genetically Engineered Mouse;glucose uptake;Glycolysis;Heterogeneity;Hypoxia;Image;imaging approach;Imaging Device;imaging Segmentation;improved;in vivo;in vivo imaging;Isotopes;journal article;Lead;Length;Link;Malignant Neoplasms;Manuscripts;Maps;mass spectrometric imaging;Membrane Potentials;Mentorship;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Methodology;Microscope;mitochondrial membrane;mitochondrial metabolism;Modeling;Molecular;molecular marker;Monitor;multiple omics;MYC gene;Nature;neoplastic cell;novel;Nutrient;Oncogenes;Oncogenic;optical imaging;Outcome;Paclitaxel;patient derived xenograft model;Patients;Perfusion;Phase;Phenotype;Positioning Attribute;Postdoctoral Fellow;Pre-Clinical Model;preference;Preparation;pressure;Property;Recurrence;Recurrent tumor;Reporter;Research;Research Personnel;Research Project Grants;Residual Neoplasm;Residual state;Resistance;Resolution;Sampling;Seminal;serial imaging;Signal Pathway;Site;skills;spatiotemporal;Stratification;System;targeted treatment;Technology;Therapeutic;therapy outcome;therapy resistant;Tissues;tool;Training;training opportunity;translational therapeutics;treatment response;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor heterogeneity;tumor metabolism;tumor microenvironment;Tumor-Associated Vasculature;uptake;Variant;Visualization;Work

PROJECT_TITLE: Understanding metabolic and vascular vulnerabilities of residual disease in triple negative breast cancer to inform on treatment strategies


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: JUPITER

ORG_NAME: MYOSIN THERAPEUTICS INC.

ORG_STATE: FL

PHR: PROJECT NARRATIVE Glioblastoma is an aggressive, fast-growing brain cancer that represents nearly half of all malignant brain tumors. Due to the high rate of recurrence, current treatment options only extend survival following initial diagnosis to one year. Building on years of basic research into the biology of glioblastoma identifying nonmuscle myosin II as a potential therapeutic target, an interdisciplinary team has been brought together with the necessary expertise in glioblastoma and myosin biology, drug development and the clinical treatment of glioblastoma to advance a small molecule inhibitor for glioblastoma therapy.

PI_NAMEs: ROSENFELD, STEVEN S (contact)

PROGRAM_OFFICER_NAME: POND, MONIQUE ADRIANNE

PROJECT_TERMS: Acceleration;Adult;Age;Alleles;Area;Basic Science;Biology;Brain;Brain Neoplasms;Cell Proliferation;Cells;chemotherapy;Chemotherapy and/or radiation;Clinic;Clinical;clinical investigation;Clinical Research;Clinical Treatment;Clinical Trials;Combined Modality Therapy;commercialization;Consensus;Country;curative treatments;Data;design;Development;Diagnosis;Disease;DNA;Doctor of Philosophy;Dose;drug development;effective therapy;efficacy testing;Environment;Excision;FDA approved;Formulation;Future;gene therapy;Genetic Engineering;Glioblastoma;Goals;Guanine;Heterogeneity;improved;In Vitro;in vivo;Incidence;Industry Standard;inhibitor;innovation;Invaded;Investigational Therapies;Isocitrate Dehydrogenase;kinase inhibitor;Laboratories;Life;Malignant neoplasm of brain;Malignant Neoplasms;manufacturing scale-up;Marketing;Medical;Modeling;Molecular Motors;mouse model;Myosin ATPase;Myosin Type II;Nature;neoplastic cell;neuro-oncology;Neurosciences;non-muscle myosin;Nonmuscle Myosin Type IIA;Nonmuscle Myosin Type IIB;novel strategies;Operative Surgical Procedures;Pathogenesis;patient derived xenograft model;Patients;Penetrance;Pharmaceutical Chemistry;Pharmacologic Substance;Phase;Phenotype;Polymorph;Positioning Attribute;pre-clinical;preclinical efficacy;preclinical study;Primary Brain Neoplasms;Proliferating;Radiation;Radiation therapy;Rattus;Recurrence;Research;Research Personnel;Resistance;Resources;Route;Safety;safety study;screening;Signal Transduction Inhibitor;Small Business Technology Transfer Research;small molecule;small molecule inhibitor;Solid;standard of care;synergism;Technology;temozolomide;Therapeutic;therapeutic target;therapy resistant;Time;Transferase;translational potential;treatment response;tumor;Validation;Work

PROJECT_TITLE: MT-125 for the Therapeutic Treatment of Glioblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-T(10)B]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: OVERALL: NARRATIVE Cancer is a deadly disease for which there is no panacea but requires a multi-pronged approach to improve the outcomes of our patients. To that end, the Herbert Irving Comprehensive Cancer Center at Columbia University Irving Medical Center/New York Presbyterian Hospital is dedicated to the vision and mission of reducing the cancer burden in our catchment area. The HICCC spans basic, translational, clinical and population research that is supported by shared resources, community outreach and engagement, training and education, and strategic investments, all converging on cancer screening, surveillance, early detection, prognosis, therapy, survivorship and palliation.

PI_NAMEs: RUSTGI, ANIL K (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Achievement;anti-cancer research;Appointment;Articulation;authority;Basic Science;Cancer Burden;cancer care;Cancer Care Facilities;Cancer Center;Cancer Center Support Grant;cancer education;cancer genomics;cancer research center director;Cancer Science;career;career development;Catchment Area;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;community engagement;Community Outreach;Continuity of Patient Care;Dedications;Disease;diversity and inclusion;Dryness;Early Diagnosis;Education and Outreach;education research;epigenomics;Faculty;Faculty Recruitment;Family;Fostering;Funding;Gifts;Grant;Herbert Irving Comprehensive Cancer Center;Hospitals;improved outcome;Infrastructure;innovation;Institution;inter-institutional;Intervention;investigator-initiated trial;Investments;Journals;laboratory facility;Laboratory Research;Leadership;Malignant Neoplasms;Medical center;member;Mentors;Mission;National Cancer Institute;New York;novel;Oncology;palliation;panacea;Patient Care;Patients;Peer Review;Population Research;Population Sciences;precision oncology;Presbyterian Church;Prevention;Prognosis;programs;Publications;recruit;Research;Research Personnel;Resource Sharing;Resources;Role;Schools;Science;Screening for cancer;Services;Structure;survivorship;Systems Biology;Training;Training and Education;Translational Research;Translations;Trust;Tumor Biology;tumor microenvironment;Underrepresented Minority;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer;Clinical Research;HIV/AIDS

PHR: PROJECT NARRATIVE (RELEVANCE STATEMENT) – OVERALL The Duke Cancer Institute, which has authority and responsibility for all cancer-related activities at Duke University and in the Duke University Health System, provides support and promotes collaborations between faculty and staff involved in cancer research, education, and patient care. This Cancer Center Support Grant facilitates oversight and integration of all cancer-related research activities, from basic research to translational studies to clinical and population investigation to community outreach to global cancer. Building upon an extensive strategic planning process, priority activities to maximize local, regional, and national impact have been identified.

PI_NAMEs: KASTAN, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Achievement;anti-cancer research;Arts;authority;Award;Basic Science;Businesses;Cancer Burden;cancer care;Cancer Center Support Grant;cancer genomics;Cancer Patient;Cancer Science;career development;Caring;Catchment Area;Clinical;clinical care;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community engagement;Community Health;Community Outreach;Complex;cost;design;Development;Direct Costs;Discipline of Nursing;Duke Comprehensive Cancer Center;Education;Engineering;Enrollment;Environment;Faculty;Faculty Recruitment;Fellowship;Funding;Future;Goals;Grant;Health;health disparity;Health system;Infrastructure;innovation;Interdisciplinary Study;Intervention;Investigation;Investments;Laboratories;Leadership;Link;Malignant Neoplasms;medical schools;Medicine;member;Mission;multidisciplinary;new technology;next generation;novel;Oncology;outpatient facility;Paper;Patient Care;Patients;Peer Review;Pilot Projects;Population;population based;Population Research;Population Sciences;Process;programs;Public Policy;Publishing;Recommendation;recruit;Research;Research Activity;Research Infrastructure;Research Personnel;Research Technics;Resource Allocation;Resource Sharing;Schools;Science;Scientist;Series;Signal Transduction;Strategic Planning;Structure;Testing;Therapeutic;therapeutic development;therapeutic evaluation;Time;Training;Training and Education;training opportunity;Translational Research;translational study;Translations;Universities;University Hospitals;Work


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention

PHR: PROJECT NARRATIVE: OVERALL There were an estimated 1.7 million new cases of cancer in the United States in 2018, and an estimated 609,000 deaths from the disease. Cancer is the second leading cause of the death in the U.S. The goal of the Fred Hutchinson/University of Washington Cancer Consortium is the elimination of cancer as a cause of suffering and death through more effective prevention, diagnosis, and treatment, deriving from fundamental insights into the biology of the disease.

PI_NAMEs: LYNCH, THOMAS JAMES (contact)

PROJECT_TERMS: Alaska;anti-cancer research;Area;base;Biology;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Detection;cancer diagnosis;Cancer Etiology;cancer therapy;carcinogenesis;Carcinogenesis Mechanism;Caregivers;Catchment Area;Cause of Death;Cessation of life;Child;Childhood;Clinical;clinical care;clinical practice;Clinical Research;Collaborations;Communities;Comprehensive Cancer Center;Computational Biology;computer studies;County;Development;Diagnosis;Diagnostic;Discipline;Disease;Educational process of instructing;Enrollment;Ensure;epigenomics;Equation;Equity;Exposure to;Faculty;Faculty Recruitment;Fostering;Funding;Genomics;Goals;graduate student;Grant;Health;Health Sciences;Hematopoietic Stem Cell Transplantation;host neoplasm interaction;Idaho;Immunology;Immunotherapeutic agent;improved;Individual;insight;Institution;inter-institutional;interdisciplinary collaboration;interest;Intervention;Investments;Knowledge;Laboratories;Laboratory Research;Leadership;Malignant Neoplasms;Measures;member;Mentors;Mission;Molecular;Montana;mortality;multidisciplinary;next generation;Outcome;outreach;pathogen;Patients;Peer Review;Population Research;Postdoctoral Fellow;Prevention;Prevention strategy;Primary Prevention;profiles in patients;programs;Public Health;Quality of Care;Research;Research Infrastructure;Research Personnel;Resources;Risk Factors;Risk Marker;Science;Secondary Prevention;Students;synthetic biology;targeted treatment;Therapeutic;therapy development;Training;Training and Education;Translating;Translational Research;Translations;Transplantation;treatment center;treatment trial;tumor;tumor metabolism;tumor progression;Underrepresented Populations;United States;Universities;Washington;Work;Wyoming


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Data Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE MOFFITT CANCER CENTER SUPPORT GRANT Moffitt Cancer Center (Moffitt) is a free-standing 501(c)3 not-for profit institution that was founded by legal statute to address cancer needs in the area, the State of Florida, and beyond, with the singular mission “to contribute to the prevention and cure of cancer.” Fully informed by the cancer burden in our community and catchment area, guided by highly effective, driven and synergistic senior leadership and a rigorous research strategic plan, supported by outstanding institutional funding, and cultivated by its five research Programs that span the basic, population, data, and clinical sciences, Moffitt fosters exceptional cancer research that spans discovery to translation to the clinic, and that has the momentum to accelerate its scientific impact for decades to come. More specifically, Moffitt’s research has provided paradigm shifts in our understanding of the cancer ecosystem, has discovered and advanced new means to prevent, treat and cure some forms of cancer that have led to changes in clinical practice and national health policy, and which over the next award period will be further accelerated by investments in research focused on: 1) our catchment area; 2) health disparities; 3) immuno-oncology; 4) metabolism; 5) data science; and 6) cancer care, delivery, and implementation science.

PI_NAMEs: CLEVELAND, JOHN L. (contact)

PROGRAM_OFFICER_NAME: PTAK, KRZYSZTOF

PROJECT_TERMS: Acceleration;Address;Advisory Committees;anti-cancer research;Area;Award;Basic Science;Black Populations;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer epidemiology;cancer prevention;Cancer Research Project;care delivery;career development;Catchment Area;Cervix Uteri;Clinic;Clinical;clinical practice;Clinical Sciences;Clinical Trials;Collaborations;Communities;community advisory board;community engagement;County;Data Science;design;Detection;Development;Doctor of Philosophy;Ecosystem;Education;education research;Elderly;Evaluation;Evolution;Exclusion;Faculty;Florida;Fostering;Foundations;Funding;Future;Grant;Growth;Health;Health behavior and outcomes;health disparity;Health Services Accessibility;High School Student;Hispanic Populations;HIV;Human Papilloma Virus-Related Malignant Neoplasm;Immunooncology;Immunotherapy;implementation science;improved;Incidence;Informatics;Infrastructure;Institution;inter-institutional;Intervention Trial;Investments;Journals;Leadership;Legal;Legal patent;Lung;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;mathematical learning;Melanoma;member;Metabolism;Minority;Mission;Molecular Medicine;National Health Policy;next generation;oncology program;Oropharyngeal;Ovarian;Patients;Peer Review;Peer Review Grants;Persons;Policies;Population;Population Sciences;prevent;Prevention;programs;Protocols documentation;Publications;Publishing;Puerto Rican;recruit;Research;research and development;Research Infrastructure;Research Personnel;Research Training;Resource Sharing;rural dwellers;Science;Scientist;screening;Series;sociodemographic group;standard of care;Strategic Planning;Structure;Students;Training;Training and Education;Translations;treatment trial;Underrepresented Minority;Vulnerable Populations;Woman

PROJECT_TITLE: Moffitt Cancer Center Support Grant


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE: Director’s Overview and Essential Characteristics Brian Druker, M.D., Center Director The OHSU Knight Cancer Institute has made numerous impactful contributions since its designation as one of the nation’s National Cancer Institute Cancer Centers in 1997. Accomplishments include establishing the paradigm of targeted cancer therapy, now referred to as precision medicine. Through the work supported by our Cancer Center Support Grant, we conduct cancer research that spans basic, clinical, and prevention and control and aims to improve outcomes for individuals in our catchment area and throughout the nation.

PI_NAMEs: SELLERS, THOMAS A (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Acceleration;Achievement;Advanced Malignant Neoplasm;Advisory Committees;anti-cancer research;anti-racism;Area;Atlases;Automobile Driving;Behavior;Blood Tests;Breast;Breast Cancer Detection;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer genome;cancer prevention;Cancer Survivor;Catchment Area;Characteristics;Climate;Clinical;Clinical Cancer Center;clinical care;Clinical Trials;cohort;Collaborations;colon cancer screening;Colonoscopy;Colorectal;combat;Communities;community engagement;community organizations;Community Outreach;community partnership;Comprehensive Cancer Center;County;Dedications;design and construction;Detection;Development;diversity and inclusion;Doctor of Medicine;Drug resistance;drug sensitivity;Early Diagnosis;Education;Employee;Enrollment;Ensure;Equity;Evaluation;Event;Exercise;Extramural Activities;Funding;Genetic;Genetic Screening;Goals;Grant;Guidelines;Health;Hereditary Nonpolyposis Colorectal Neoplasms;Human;Human Papilloma Virus Vaccination;Immunotherapeutic agent;improved;improved outcome;Individual;Infrastructure;innovation;Institution;International;Intervention;investigator-initiated trial;Investments;Knowledge;Lead;Leadership;leukemia;leukemia/lymphoma;Lung;lung cancer screening;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;Melanoma;member;Mission;Molecular Target;molecular targeted therapies;National Cancer Institute;NCI-Designated Cancer Center;next generation;Oncology;Oregon;Pancreas;pandemic disease;Patient-Focused Outcomes;Patients;Peer Review;Performance;Persons;Pilot Projects;population based;precision medicine;precision oncology;Prevention;Prevention strategy;Process;professional atmosphere;programs;Proteomics;Publications;Publishing;recruit;Reporting;Research;Research Personnel;Resource Sharing;Science;Screening for cancer;screening guidelines;Solid Neoplasm;Strategic Planning;symposium;Systems Biology;targeted cancer therapy;targeted treatment;Testing;The Cancer Genome Atlas;Tobacco use;Training;Training and Education;Training Programs;translational oncology;translational progress;Treatment Side Effects;treatment trial;Treatment-Related Cancer;Trust;tumor;Tumor Biology;tumor-immune system interactions;Tumor-infiltrating immune cells;Universities;Work

PROJECT_TITLE: OHSU Knight Cancer Institute


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Tobacco

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: OVERALL PROJECT NARRATIVE The UCLA Jonsson Comprehensive Cancer Center (JCCC) strategic mission is to accelerate discoveries that prevent and cure cancer. Through a deep and broad spectrum of impactful research endeavors, clinical and research education and training programs, and the highest quality of patient care in multiple academic and community settings, the JCCC seeks to reduce the burden of cancer throughout its Los Angeles County catchment area and the nation.

PI_NAMEs: TEITELL, MICHAEL A (contact)

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Applications Grants;Area;Biomedical Engineering;Breast Cancer survivor;Cancer Burden;cancer cell;Cancer Center Support Grant;Cancer Control;cancer education;Cancer Patient;cancer prevention;cancer risk;Cancer Survivorship;care delivery;career;career development;Caring;Catchment Area;Cell Therapy;Cells;Clinical;Clinical Research;Clinical Sciences;Clonal Evolution;colorectal cancer screening;Communication;Communities;community engagement;Community Outreach;community partners;community setting;Complement;Comprehensive Cancer Center;County;dashboard;Detection;Diagnostic;Early Diagnosis;Education;education research;Educational workshop;Electronic cigarette;electronic cigarette use;Environment;Epigenetic Process;epigenomics;ethnic minority population;Event;Evolution;Faculty;FDA approved;Fellowship Program;fighting;first-in-human;follow-up;Fostering;Gene Expression Regulation;Genetic;Grant;Guidelines;Healthcare;Immigrant;Immune;Immune response;Immune system;Immunotherapy;improved;Individual;infection related cancer;innovation;Institution;Intervention Studies;Laboratories;Leadership;Learning;Lesion;Los Angeles;Low income;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;member;Mentors;Metabolic;metastatic process;Mission;molecular imaging;Nanotechnology;Neoplasm Metastasis;Obesity;Occupations;Organizational Change;Patient Care;patient oriented;Patients;Population Sciences;Postdoctoral Fellow;premalignant;prevent;Prevention;Prevention strategy;programs;prospective;Recurrence;Research;Research Personnel;Resource Sharing;Risk;RNA;Scientist;screening;Signal Transduction;Sleeplessness;stem;stem cell biology;Strategic Planning;survivorship;targeted treatment;theranostics;Therapeutic;Training;Training Activity;Training and Education;Training Programs;translational research program;treatment and outcome;tumor;tumor heterogeneity;tumor immunology;Uncertainty;United States National Institutes of Health;Vaccination;Vision;Writing


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Tobacco


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE The Fred & Pamela Buffett Cancer Center (BCC), the only NCI-designated cancer center in Nebraska, is a matrix cancer center at the University of Nebraska Medical Center and our affiliated healthcare network, Nebraska Medicine. The Mission of the BCC is to promote innovative translational cancer research, excellence in cancer education and training, and outstanding patient-centered cancer care and to reduce the burden of cancer and cancer health disparities across Nebraska and beyond.

PI_NAMEs: SWEASY, JOANN B. (contact)

PROJECT_TERMS: Address;anti-cancer research;Award;Basic Science;Biological Markers;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer health disparity;cancer initiation;Catchment Area;Clinical;Clinical Cancer Center;clinical care;Clinical Research;Clinical Sciences;Clinical Trials;Communities;community engagement;Community Outreach;community partners;computational chemistry;Development;Direct Costs;Early Diagnosis;Education;Environment;Fostering;Funding;Health care facility;health disparity;Healthcare;innovation;interdisciplinary collaboration;Intervention;Leadership;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Medical center;Medicine;member;metabolomics;Mission;Modeling;multidisciplinary;Names;NCI-Designated Cancer Center;Nebraska;novel therapeutic intervention;Organoids;outreach;patient oriented;Patients;Pharmaceutical Chemistry;Physicians;Population Sciences;Positioning Attribute;preclinical imaging;Prevention;Prognosis;programs;recruit;Reporting;Research;research facility;Research Infrastructure;Research Peer Review;Research Support;Resource Sharing;Resources;Risk;Role;Scientific Advances and Accomplishments;Synthesis Chemistry;Teacher Professional Development;Tissue Microarray;Training and Education;translational cancer research;Translational Research;tumor progression;underserved community;Universities

PROJECT_TITLE: Buffett Cancer Center Support Grant


NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: OVERALL: PROJECT NARRATIVE The OU Stephenson Cancer Center fulfills a unique need in Oklahoma and the region by conducting innovative and impactful research that seeks to translate novel discoveries into the clinical or community setting through a transdisciplinary team-based approach. The goal of these efforts is to decrease cancer incidence and improve outcomes for Oklahomans and all individuals, with a special emphasis on promoting cancer health equity among the state’s underserved minority populations.

PI_NAMEs: MANNEL, ROBERT S. (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Address;African American;American Indian Tribe;American Indians;Biomedical Research;Black race;cancer care;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;Catchment Area;Clinical;Clinical Trials;Collaborations;Colon Carcinoma;Communities;Community Outreach;community setting;design;Disparity;Education;Ensure;Faculty;Fostering;Funding;Goals;Grant;Growth;Health;health equity;health equity promotion;Health Professional;Health Technology;improved outcome;Incidence;Individual;Infrastructure;innovation;Intervention;Investments;Leadership;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;member;Mentorship;mHealth;Minority Groups;Mission;morphogens;mortality;multidisciplinary;NCI-Designated Cancer Center;next generation;novel;Oklahoma;Oncology;outreach;patient oriented;Persons;Population;Positioning Attribute;programs;Publications;recruit;Reporting;Research;Research Activity;Research Peer Review;Resources;Rural Population;Science;Site;social health determinants;Strategic Planning;Students;Therapeutic;tobacco control;Training;Training Activity;Translating;Translations;underserved minority;United States National Institutes of Health;Universities;Vision;Vulnerable Populations;Woman

PROJECT_TITLE: Stephenson Cancer Center - Cancer Center Support Grant


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE: OVERVIEW Cancer affects 1 in every 3 people in the US and as our population ages this fraction is expected to increase. Outcomes for cancer patients have improved over the last several decades, but there is still a great burden of cancer-related mortality and morbidity that is borne disproportionately by minorities and the economically disadvantaged. MD Anderson Cancer Center's mission is to eliminate cancer in Texas, the nation and the world through outstanding programs that integrate patient care, research and prevention, and through education for undergraduate and graduate students, trainees, professionals, employees and the public. Our vision is to be the premier cancer center in the world based on the excellence of our people, our research-driven patient care and our science.

PI_NAMEs: DRAETTA, GIULIO FRANCESCO (contact)

PROJECT_TERMS: Acceleration;Affect;Age;anti-cancer research;Area;Award;Basic Science;Behavioral Sciences;Biology;Budgets;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;Cancer Survivorship;care seeking;Caring;Catchment Area;Clinic;Clinical;clinical practice;Clinical Research;Clinical Research Protocols;Clinical Trials;Collaborations;Communities;community engagement;Comprehensive Cancer Center;data integration;Dedications;design;Detection;Development;Diagnosis;Direct Costs;Drug Approval;E-learning;Early Diagnosis;economic disparity;Education;Educational Curriculum;Educational Models;effective intervention;Employee;Enrollment;Epigenetic Process;evidence base;Exclusion;Faculty;Foundations;Future;Generations;graduate student;Grant;health disparity;Hospitals;Human;human subject;Image;Immunology;improved;innovation;insight;Institution;Interdisciplinary Study;Internet;Intervention;Investigation;Investments;Journals;Knowledge;Laboratories;Learning;Location;Malignant Neoplasms;member;Mentorship;Minority;Mission;Molecular Epidemiology;Moon;Morbidity - disease rate;mortality;multidisciplinary;NCI-Designated Cancer Center;Newly Diagnosed;Oncology;operation;Outcome;Participant;Patient Care;Patients;Persons;Population;population based;Population Research;Population Sciences;prevent;Prevention;programs;prospective;rare cancer;recruit;Research;research clinical testing;Research Personnel;Research Project Grants;Research Training;Resistance;Resource Sharing;Science;Services;Specimen;standard of care;survivorship;System;targeted agent;Technology;tenure track;Texas;Therapeutic;therapy design;Training;Training and Education;Training Programs;Translational Research;Translations;treatment strategy;undergraduate education;undergraduate student;Universities;University of Texas M D Anderson Cancer Center;Vision


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE The University of Wisconsin Carbone Cancer Center (UWCCC), which is a matrix center within the University of Wisconsin School of Medicine and Public Health (SMPH), seeks to dramatically reduce the burden of cancer within and beyond our catchment. Specifically, the UWCCC will do this by decreasing cancer incidence and mortality among populations within our catchment area and beyond, including our minority and underserved populations. We will facilitate pursuit of this goal through partnerships with other health delivery systems and state and community agencies for dissemination of evidence-based findings. The UWCCC will accomplish our goals through nurturing a diverse and supportive cancer community, reliable infrastructure, and efficient resources. During the current funding period, UWCCC continued to decrease the burden of cancer in our catchment and beyond through prioritized research areas (e.g., innovative therapies and biomarkers, cancer imaging and expanded population-based cancer research), enhanced research platforms (e.g., improved clinical research infrastructure and shared resources), increased efforts to build mission-related philanthropy, and expanded local-to-global partnerships.

PI_NAMEs: BAILEY, HOWARD H. (contact)

PROJECT_TERMS: Acceleration;anti-cancer research;Area;Award;Biological Markers;Cancer Burden;cancer care;Cancer Center;Cancer Control;cancer genetics;cancer imaging;Cancer Model;cancer prevention;cancer therapy;Catchment Area;Clinical;Clinical Research;Communication;Communities;Comprehensive Cancer Center;Developmental Therapeutics Program;Diagnosis;Education;Ensure;Epigenetic Process;Equity;equity, diversity, and inclusion;evidence base;Faculty;Family;Funding;Goals;Grant;Growth;health care delivery;Human;Image;Immunologics;improved;Incidence;Individual;Infrastructure;innovation;Innovative Therapy;Institution;inter-institutional;Intervention;Journals;Knowledge;Leadership;Malignant Neoplasms;Manuscripts;medical schools;member;Minority Groups;Minority Participation;Mission;mortality;Names;Nature;next generation;Patients;Peer Review;Persons;Population;population based;Prevention;programs;Provider;Public Health;Publications;Publishing;Radiation;recruit;Research;Research Infrastructure;Research Personnel;Research Priority;Resource Sharing;Resources;Schools;Science;Services;Societies;Technology;Training;tumor microenvironment;Underrepresented Minority;Underserved Population;Universities;virology;Wisconsin;Work

PROJECT_TITLE: UW Comprehensive Cancer Center Support


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: OVERALL: PROJECT NARRATIVE The Alvin J. Siteman Cancer Center (SCC) at Washington University and Barnes-Jewish Hospital is a NCI designated Comprehensive Cancer Center whose mission is to prevent cancer in the community and transform cancer patient care through scientific discovery. SCC accomplishes this mission through strong research programs, shared resource support, education and training, pilot funding programs, and community outreach. The translational research and scientific discovery facilitated by our seven multidisciplinary research programs and 10 shared resources (11th requested in this application) is driven by the needs of patients in our 82-county catchment area throughout Missouri and southern lllinois.

PI_NAMEs: EBERLEIN, TIMOTHY J (contact)

PROJECT_TERMS: anti-cancer research;Area;bench to bedside;burden of illness;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;cancer diagnosis;cancer imaging;Cancer Patient;cancer therapy;Catchment Area;clinical care;Clinical Trials;Collaborations;Communities;Community Outreach;community partnership;Comprehensive Cancer Center;County;Data;Development;disparity reduction;Diverse Workforce;Exclusion;follower of religion Jewish;Funding;Genomics;Grant;Health Services Accessibility;Hematopoietic;Hospitals;Illinois;imaging science;Imaging technology;Immunology;Immunotherapy;implementation science;Incidence;innovation;Institution;Interdisciplinary Study;Intervention;Malignant Breast Neoplasm;Malignant Neoplasms;member;Methods;Mission;Missouri;Molecular;mortality;multidisciplinary;Neoplasm Metastasis;novel;Pathway interactions;Patient Care;patient population;Patients;personalized medicine;prevent;Prevention;Prevention strategy;programs;Publications;Regional Cancer;Research;Research Personnel;Resource Sharing;Risk Factors;Risk Reduction;Schools;Science;Screening for cancer;Solid Neoplasm;Speed;Strategic Planning;success;Talents;Therapeutic;Time;Tissues;Training and Education;Translating;Translational Research;tumor immunology;tumor progression;Underserved Population;Universities;Washington


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Activity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Our goal is to improve control of cardiovascular (CV) disease risk factors defined by the American Heart Association’s Life’s Simple 7 (blood glucose, cholesterol, blood pressure, physical activity, weight, diet, and smoking) by engaging patients experiencing health disparities in an innovative technology-based self- management intervention with linkages to health system providers. Using a patient-level randomized pragmatic trial design, we will enroll 6,000 patients from three Federally Qualified Health Centers, Denver Health and Hospital Authority, Salud Family Health Centers, or STRIDE Community Health Center. The study findings will provide evidence regarding the best population-based strategy for universal delivery to engage all patients experiencing health disparities in self-management to improve CV disease risk factors.

PI_NAMEs: BULL, SHEANA S;HO, P. MICHAEL  (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Adherence;Advocate;Affect;American Heart Association;Architecture;Artificial Intelligence;Attention;authority;Behavior;Behavioral;Black race;Blood Glucose;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Categories;Cellular Phone;Cessation of life;chatbot;Cholesterol;Chronic;Chronic Disease;Clinic;Clinical;clinical care;Colorado;Communication;Communities;comparative effectiveness;Competence;contextual factors;County;Data;Data Collection;Decision Making;Diabetes Mellitus;Diet;disorder control;Disparity;effectiveness outcome;Electronic Health Record;Eligibility Determination;Emerging Technologies;Enrollment;Equity;ethnic minority;evidence base;experience;Family health status;Federally Qualified Health Center;Focus Groups;Future;Goals;Group Interviews;Health;Health behavior;Health behavior change;Health Care Costs;health care service utilization;health disparity;health equity;Health Personnel;Health Services Accessibility;Health system;Healthcare Systems;healthy lifestyle;Hispanic;Hospitalization;Hospitals;Hypertension;implementation framework;implementation outcomes;Improve Access;improved;Individual;Infrastructure;innovative technologies;Intervention;intervention delivery;intervention mapping;intervention refinement;Intervention Studies;Intuition;Latino;Lead;Life;Life Style;lifestyle factors;Limited English Proficiency;Location;Low income;medication compliance;Methods;Morbidity - disease rate;Myocardial Infarction;Neighborhood Health Center;Outcome;patient engagement;patient population;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Phase;Physical activity;Pilot Projects;Population;population based;pragmatic randomized trial;Prevention program;primary outcome;programs;Provider;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Risk;Risk Factors;Role;rural patients;safety net;Sampling;Self Care;Self Efficacy;Self Management;Smoking;social culture;Social Environment;social health determinants;sociocultural determinant;Spanish;Target Populations;Technology;Testing;Text Messaging;text messaging intervention;theories;trial design;Update;Weight

PROJECT_TITLE: Using artificially intelligent text messaging technology to improve American Heart Association's Life's Simple 7 Health Behaviors: LS7 Bot + Backup


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Structural ableism drives many of the health inequities faced by disabled people across social determinants of health, healthcare access, healthcare quality, and health outcomes. This project will characterize dimensions of structural ableism, and create measures to assess it which are essential first steps to identifying how structural ableism impacts health outcomes among disabled people. This work will provide measures needed to identify and evaluate novel interventions aimed at dismantling structural ableism, which should be co-created with the disability community.

PI_NAMEs: SWENOR, BONNIELIN ;VALDEZ, RUPA SHETH (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: access disparities;Address;Advisory Committees;Advocate;Ageism;American;Characteristics;classism;Communities;community engagement;community partnership;Complex;Cultural Anthropology;Data Set;demographics;Development;Dimensions;disability;Disability research;disabled;Disabled Persons;Disparity;Engineering;Ethnic Origin;Etiology;experience;Foundations;Gender Identity;Geographic Locations;Goals;Health;health care availability;health care quality;health disparity;health disparity populations;health equity;health inequalities;Health Policy;Health Sciences;improved;Individual;infancy;informant;Institution;instrument;Intervention;Interview;Link;Measurement;Measures;Medicine;member;novel;Outcome;Paper;Pathway interactions;perceived discrimination;Persons;Phase;Play;Policies;Process;Public Health;PubMed;Race;Research Personnel;Science;Sexism;Shapes;social health determinants;sociology/anthropology;stem;structural ableism;Structural Racism;Surveys;System;Testing;Translating;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Identifying and Measuring Domains of Structural Ableism to Advance Health Equity for the Disability Community

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-D (50)]


ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Basement membranes are strong thin sheets of protein and carbohydrates found in all animals, and they lie underneath cell sheets and wrap around muscles, nerves, and organs. Basement membranes have many functions, including mechanical stability, filtering the blood, and insulating tissues so they do not receive inappropriate signals from other parts of the body. Part of the basement membrane appears to be less stable than other parts, and we will investigate what this means for basement membrane overall stability and function.

PI_NAMEs: PAGE-MCCAW, ANDREA  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Adult;Animals;Back;Basement membrane;Binding;Biological Assay;blood filter;blood filtration;Blood Vessels;blood-brain barrier function;Body part;Carbohydrates;Cells;circadian;circadian pacemaker;clinically significant;Collagen;Collagen Type IV;crosslink;Darkness;Deposition;Dermatologist;Diabetes Mellitus;Drosophila genus;Electron Microscopy;Embryo;Environment;Epithelium;Excision;Extracellular Matrix;Funding;Health;Human;Human body;Inflammation;Kidney;Kinetics;Light;Measures;mechanical properties;Mechanics;Membrane Biology;Membrane Proteins;Modeling;Morphogenesis;Morphology;Muscle;Muscle function;mutant;Nature;Neoplasm Metastasis;Nerve;Oncologist;Organ;Ovary;Periodicity;perlecan;Physicians;Polymers;Property;protein crosslink;Proteins;Recycling;Regulation;repaired;Reporting;Research Personnel;restraint;Signal Transduction;Structure;Surgeon;System;Tensile Strength;Thick;Thinness;tissue fixing;Tissues;Tube;tumor;Work;wound;wound healing

PROJECT_TITLE: Investigating the Mobile Fraction of Basement Membranes

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rehabilitation;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Title: Determining the relationships between provider bias, experiences of ableism, and health outcomes for people with mobility disabilities Project Narrative The goal of this project is to investigate mechanisms through which ableism in healthcare settings impacts people with mobility disabilities (PWMD) and their health outcomes. The research team will collect quantitative and qualitative data related to both episodic and cumulative experiences of perceived ableism of PWMD, explicit and implicit disability biases of rehabilitation professionals from whom they receive care, and their health outcomes such as self-perceived health status, depression, anxiety, pain, participation, quality of life, and measures of healthcare utilization. This work will fill a critical gap in understanding underlying mechanisms that perpetuate ableism in healthcare so that more effective bias-mitigating solutions may be developed and evaluated in the future, to ultimately reduce disparities and maximize participation, health, and quality of life in partnership with PWMD.

PI_NAMEs: FELDNER, HEATHER ANN;WOROBEY, LYNN A (contact)

PROJECT_TERMS: ableism;Address;Adult;Anxiety;Attitude;barrier to care;care episode;care providers;Caring;Clinical;clinical care;cohort;cost;cultural competence;Data;Data Collection;design;Disabilities experience;disability;Disability outcome;Disabled Persons;Discrimination;disparity reduction;Documentation;Electronic Health Record;Enrollment;Environment;Event;Exhibits;experience;explicit bias;Future;Goals;Health;health care service utilization;health care settings;health disparity populations;Health Personnel;Health Status;Healthcare;Healthcare Systems;Impairment;implicit bias;Interview;Knowledge;Literature;Lived experience;Maps;Measures;Medical Records;Mental Depression;Methods;Mobility disability;multidisciplinary;Natural Language Processing;Observational Study;Outcome;Outpatients;Pain;Patient Self-Report;Patient-Focused Outcomes;Pattern;Perception;Persons;poor health outcome;Population;Prejudice;prospective;Provider;psychologic;Quality of life;Recovery;Rehabilitation therapy;rehabilitative care;Reporting;Research;Role;Site;social;social health determinants;Structure;System;Technology;theories;Work


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Mental Health;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative The goal of this project is to uncover the genetic control of social brain maturation and function during adolescence and how this unfolds differently in males and females. To achieve this, using the mouse as a model, we will mutagenize the transcription factor encoding gene, Foxp2, specifically in the amygdala, a central brain structure driving social-emotional changes that occur during adolescence. As mutations in Foxp2 in humans have been reproducibly associated with neurodevelopmental/behavioral conditions such as autism spectrum disorder, ADHD and language impairment, most of which differ across gender, our understanding of the genetic mechanisms of adolescent brain development is a critical step toward designing rational interventional and therapeutic approaches based on the underlying biology of these conditions. .

PI_NAMEs: CORBIN, JOSHUA G (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent brain development;Aggressive behavior;Amygdaloid structure;Animals;Anxiety;Anxiety Disorders;Attention deficit hyperactivity disorder;autism spectrum disorder;Automobile Driving;Basal Ganglia;Behavior;Behavioral;behavioral response;Biology;Brain;brain circuitry;Brain region;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;critical period;Cues;Development;differential expression;Disease;Emotional;emotional behavior;Emotional disorder;Emotions;epigenomics;Female;Fiber;FOXP2 gene;Functional disorder;Gender;Gene Expression;gene function;gene-editing approach;Genes;Genetic;Genetic Transcription;genomic profiling;Goals;Head;Human;in vivo;Instinct;Intervention;Knowledge;language impairment;Link;male;Measures;Medial;Mediating;Mental Depression;Modeling;Motivation;multiple omics;Mus;Mutagenesis;Mutagens;Mutant Strains Mice;Mutate;Mutation;neurobehavioral;neurobehavioral disorder;neurodevelopment;Neurodevelopmental Disorder;neuronal circuitry;Neurons;Nuclear RNA;Output;Photometry;Play;Population;Process;Proteomics;rational design;Regulation;Reproducibility;response;Role;Schizophrenia;sex;Sex Bias;Sex Differences;social;Social Behavior;Social Controls;social deficits;Social Network;Songbirds;stem;Structure;Synapses;synaptogenesis;targeted delivery;Testing;Therapeutic;Time;tool;transcription factor;transcriptome sequencing;transcriptomics;Viral;Virus;Vulnerable Populations;Work

PROJECT_TITLE: Foxp2 genetic control of sex differences in amygdala-driven social behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-Y (02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE Despite the growing number of women with intellectual and developmental disabilities (I/DD) giving birth, very little is known about the impact of ableism on their access to healthcare and service use during pregnancy, delivery, and postpartum periods. Using 2016-2023 national Medicaid claims linked to community-level information about social determinants of health, state Medicaid policy data, and other data sources, the proposed study will conduct a detailed examination of service access and delivery to birthing people with I/DD aged 14 to 50 who have experienced a delivery and will compare outcomes experienced by this group and their linked infants to those of their Medicaid-enrolled peers without I/DD. Paired with surveys and interviews of obstetric service providers identified through Medicaid claims, this mixed methods study will result in the most substantive work to date to identify the impact of ableism on birthing people with I/DD at both the clinical care (attitudinal ableism) and system (Medicaid policy, structural ableism) levels.

PI_NAMEs: SHEA, LINDSAY LAWER (contact)

PROJECT_TERMS: ableism;Address;Adolescent;Affect;Age;Age Years;aged;Attitude;autism spectrum disorder;Awareness;beneficiary;Birth;black women;care systems;Caring;Censuses;Child;Child Health;Child Welfare;Childbirth;clinical care;cohort;Communication;Communities;comorbidity;Country;Data;Data Collection;Data Set;Data Sources;design;Diagnosis;disability;Disability status;Disabled Persons;Discipline of obstetrics;Disparity;Enrollment;Environment;ethnic diversity;ethnic minority population;Ethnic Population;Event;experience;Funding;General Population;Goals;Gynecologist;Health;health care availability;health care delivery;health care service utilization;Health Insurance;Health Personnel;Health Policy;health service use;Health Services;Health Services Needs;Health system;Healthcare;high risk population;improved;improved outcome;Individual;Infant;infant morbidity/mortality;insight;instrument;Insurance Carriers;Intellectual functioning disability;Interview;Life;Link;Maternal Health;maternal morbidity;Maternal Mortality;maternal risk;Medicaid;Medical;Mental Health;Methods;Morbidity - disease rate;mortality;Neonatal;obstetric services;Outcome;Patients;peer;perinatal mental health;Persons;Physicians;Policies;Population;postnatal;Postpartum Depression;postpartum health;postpartum outcome;Postpartum Period;Pregnancy;Pregnancy Rate;Preventive care;Provider;provider factors;psychiatric disability;Race;racial minority population;racial population;Readiness;Reproductive Health;Risk;Role;Sampling;Screening for cancer;Sensory;service delivery;service providers;Services;social health determinants;structural ableism;Surveys;Symptoms;System;systemic intervention;Time;Training;Translating;Underserved Population;Vaccination;Woman;women with disabilities;Women's Group;women's outcomes;Work

PROJECT_TITLE: Identifying the impact of ableism on maternal health outcomes among Medicaid-enrolled women with IDD


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunotherapy;Palliative Care;Patient Safety;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative/Relevance This study will examine changes in the organization of oncology care providers over time and the impact of these changes on the quality of care, diffusion of new therapies, health care utilization, and outcomes for cancer patients overall and for vulnerable/disadvantaged subgroups. The findings will provide oncology practitioners, payers, and policy makers valuable information to improve access, quality and outcomes of cancer care. Our results also will inform policies and practices related to the value of integration of oncology care, quality measurement, design of alternative payment models, and development of innovative delivery models to care for vulnerable/disadvantaged populations.

PI_NAMEs: KEATING, NANCY L (contact);LANDRUM, MARY BETH

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Academy;acute care;American;Area;Breast;bundled payment;cancer care;Cancer Hospital;Cancer Patient;Capital;CAR T cell therapy;care coordination;care delivery;care providers;Caring;Clinical Data;Collaborations;Complex;Comprehensive Health Care;Country;Data;Data Set;Data Sources;Databases;design;Development;Diagnostic;Diffusion;Disparity population;Enrollment;ethnic minority;Evaluation;evidence base;Expenditure;experience;Fee-for-Service Plans;Foundations;genetic testing;Genomics;Growth Factor;Guidelines;health care service utilization;health information technology;Health system;Healthcare Systems;hospice environment;hospital care;Hospitals;Immunotherapy;Improve Access;improved;Incentives;Individual;Infrastructure;innovation;Investments;Knowledge;Link;Malignant Neoplasms;Marketing;Measurement;Measures;Medicaid;Medicare;Medicine;Modeling;multiple chronic conditions;Neutropenia;novel;novel therapeutics;Oncology;Organizational Change;Outcome;Ownership;Palliative Care;participant enrollment;Patient Care;Patient Outcomes Assessments;patient population;Patients;payment;Performance;Pharmaceutical Preparations;Physicians;Policies;Policy Maker;Population;Poverty;Price;programs;Provider;Quality of Care;racial minority;Recommendation;Records;Regimen;Reporting;Risk;Rural;rural area;Source;survivorship;System;Systems Integration;targeted treatment;Taxes;Test Result;Testing;Time;trend;tumor;Underserved Population;United States Agency for Healthcare Research and Quality;United States Centers for Medicare and Medicaid Services;Variant;Vulnerable Populations

PROJECT_TITLE: Effects of Provider Integration on the Diagnostic Evaluation of Breast Complaints in Medicare Patients


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: LITTLE ROCK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative Public Health Relevance: Malaria is a disease caused by protozoan parasites of the genus Plasmodium, which is transmitted by mosquitos. Despite the ongoing eradication campaigns and availability of effective anti-malarial drugs this disease remains a global burden to human health, resulting in over 200 million of deaths per year, primarily in children under the age of five. Thus, an emphasis has been placed on understanding how the immune response, innate and adaptive, provides protection against this infection in order to determine how protective immunity can be enhanced in a vaccine setting to ultimately provide and maintain immunity against this disease.

PI_NAMEs: STUMHOFER, JASON S (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: acute infection;adaptive immune response;Adaptive Immune System;Adoptive Transfer;Affect;Age;Anemia;Anti-malarials;Antiparasitic Agents;BHLH Protein;Biological Assay;Blood;Bone Marrow;burden of illness;cell mediated immune response;cell type;Cells;Cessation of life;Child;Chimera organism;Collaborations;Communicable Diseases;Culicidae;cytokine;Data;Dichloromethylene Diphosphonate;Disease;Effector Cell;Erythrocytes;Excision;experimental study;Gene Expression;Gene Expression Profile;Genetic Transcription;Goals;Growth;Health;Height;Helix-Turn-Helix Motifs;Human;Immune response;Immunity;improved;In Vitro;in vivo;Infection;Inflammatory;Innate Immune Response;Innate Immune System;insight;Interferon Type II;Lead;Link;Liposomes;Macrophage;Malaria;Mediating;Mediator;Metabolism;Modeling;monocyte;Mus;Myeloid Cells;Nitrogen;Oxygen;Parasite Control;Parasites;Pathway interactions;Peritoneal;Peritoneal Macrophages;Phagocytes;Phenotype;Plasmodium;Play;Pleural;Population;Predisposition;Production;programs;Proliferating;Public Health;public health relevance;recruit;Regulation;response;restraint;Role;Spleen;T-Lymphocyte;Testing;Time;Tissues;transcription factor;transcriptome sequencing;transmission process;Vaccines;Work

PROJECT_TITLE: Regulation of macrophage function during acute infection with Plasmodium

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stroke

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: It is estimated that about 50,00 to 60,000 people in the US are affected by frontotemporal dementia. The successful completion of the proposed study will increase our understanding of the pathophysiology of motor symptoms and aphasia of frontotemporal dementia and develop new and effective treatments for frontotemporal dementia patients.

PI_NAMEs: LI, YUQING  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acceleration;Address;Affect;Alternative Splicing;Anatomy;Animal Model;Aphasia;Apraxia;Area;associated symptom;Atrophic;Basal Ganglia;Behavior;behavior test;Behavioral;behavioral variant frontotemporal dementia;Biochemical;Bradykinesia;Brain;Broca Aphasia;cell type;cholinergic;Communication;conditional knockout;Core Facility;Corpus striatum structure;corticobasal syndrome;Cyclic Nucleotides;Data;Decision Making;Deglutition Disorders;Degradation Pathway;Dementia;Deterioration;Development;Dysarthria;early onset;effective therapy;Environment;Equilibrium;executive function;experience;Frontotemporal Dementia;Functional disorder;Funding;Genetic;Genetic Transcription;Goals;granulin;GRN gene;Grooming;Heterozygote;Homologous Gene;Human;illness length;Immunohistochemistry;in vitro activity;Individual;interdisciplinary approach;Interneurons;Knock-in Mouse;Knock-out;Knockout Mice;Language;Language Disorders;Lead;Learning;Lesion;Limb Dystonia;Lobe;loss of function;Lysosomal Storage Diseases;Memory;Metabolism;Morphology;Motor;motor disorder;Motor Skills;motor symptom;mouse model;Movement Disorders;mRNA Expression;mRNA Stability;Mus;Mutant Strains Mice;Mutation;Myoclonus;Nervous System Disorder;Neuronal Ceroid-Lipofuscinosis;Neurons;neurophysiology;non-motor symptom;novel;novel therapeutics;Parkinsonian Disorders;Pathologic;Patients;Pattern;Personality;Persons;PGRN gene;Primary Progressive Aphasia;Progressive Nonfluent Aphasias;Property;protein expression;protein TDP-43;Proteins;putamen;Research;research facility;Research Personnel;Semantic Dementias;Social Behavior;Subcategory;Symptoms;targeted treatment;Techniques;Testing;Thalamic structure;ultrasound;United States National Institutes of Health;Variant;vocalization;Walking;Work

PROJECT_TITLE: Striatal Contribution to the Motor Symptoms and Aphasia in GRN-FTD

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Rehabilitation;Social Determinants of Health

ORG_CITY: LUBBOCK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEXAS TECH UNIVERSITY

PHR: PROJECT NARRATIVE Ableism as a Mechanism of Physical and Mental Health Inequities Among Children with Visual Impairment Children who are blind or visually impaired (CBVI) experience high rates of physical and mental health disor- ders, which may be driven by ableism. Ableism harms people with disabilities, such as CBVI, by excluding them from full participation in society, but the specific impact of ableism on the physical and mental health of CBVI has not been examined. The proposed study seeks to identify the role of ableism in driving physical and mental health inequities within CBVI in order to reveal how ableism “gets under the skin” and results in poor health outcomes for these vulnerable children.

PI_NAMEs: SCHMIDT, ADAM THOMAS (contact);VICTOR, SARAH ELIZABETH

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: ableism;Ableist;Accelerometer;Affective;Age;Age of Onset;American;Anxiety;Asthma;Automobile Driving;Belief;blind;Blindness;caregiver interventions;Caregivers;Centers for Disease Control and Prevention (U.S.);Child;Child Mental Health;Childhood;Childhood Leukemia;Chronic;Clinical;Cognitive;Collaborations;Communities;Data;design;Developmental Disabilities;Diagnosis;disability;Disabled Persons;Discrimination;Distal;Economics;Education;Environment;Exclusion;experience;Family;Fostering;Functional impairment;Funding;Goals;Grant;Health;health care availability;health disparity;health inequalities;Health Personnel;health related quality of life;Health Status;hearing impairment;improved outcome;Individual;informant;internalized stigma;Intervention;Interview;lens;Life;Link;Lived experience;Measures;Mental Depression;Mental disorders;Mental Health;Methods;Minor;Minority Groups;minority stress;Motor disability;Neighborhoods;Obesity;Occupational;Outcome;Parents;Patient Self-Report;Physical activity;Physical assessment;physical conditioning;poor health outcome;Population;Postdoctoral Fellow;Prejudice;Prevalence;psychological distress;Psychosocial Factor;Recording of previous events;Recreation;recruit;Reporting;Research;Research Project Grants;Role;Sampling;satisfaction;Self Perception;Skin;sleep quality;Social Environment;social health determinants;Societies;Symptoms;Techniques;theories;therapy design;therapy development;United States;Victimization;virtual;Vision;Visual impairment;Youth


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Radiation Oncology;Rare Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE (parent award, R01 CA251110), unchanged Radiation therapy for the clinical management of brain tumors and metastases is linked with severe cognitive decline and neuroinflammation in cancer survivors. We hypothesize that radiation-induced aberrant activation of the glial complement cascade play a causal role in development of cognitive impairments. This proposal will address glial complement activation mechanism and translationally feasible intervention to curtain this unmet medical need.

PI_NAMEs: ACHARYA, MUNJAL M (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Ablation;Acute;Address;Adult;Aftercare;Alzheimer's Disease;Anaphylatoxins;Animals;antagonist;Apoptotic;Astrocytes;astrogliosis;Behavior assessment;Biopsy;blood-brain barrier permeabilization;Brain;brain dysfunction;Brain Injuries;Brain Neoplasms;C5a anaphylatoxin receptor;cancer invasiveness;Cancer Survivor;cancer therapy;Cells;Chronic;Clinical;Clinical Management;clinically relevant;Cognition;Cognitive;Cognitive deficits;cognitive function;Complement;Complement 1q;complement 1q receptor;Complement 3a;Complement 5a;Complement Activation;complement system;Complex;Cranial Irradiation;cytokine;Data Set;design;Development;Dose;effectiveness testing;Epilepsy;Foundations;Gene Expression Profile;Genes;Genetic;glial activation;Glioma;Gliosis;Hour;Human;Hypertrophy;Immune signaling;Immunocompetent;Impaired cognition;Impairment;improved;Inflammation;Intervention;knock-down;Link;link protein;Malignant neoplasm of brain;Malignant neoplasm of central nervous system;Malignant Neoplasms;Mediating;Mediator;Medical;Metastatic malignant neoplasm to brain;Microglia;Molecular;mouse model;Mus;Nerve Degeneration;Neurobiology;neurogenesis;neuroinflammation;neuroprotection;neurotransmission;novel;Oral;Outcome Study;Oxidative Stress;parent project;Patients;pediatric low grade glioma;pharmacologic;Play;Production;Prognosis;Proteins;Quality of life;Radiation;Radiation therapy;receptor;Receptor Inhibition;Reporting;response;restoration;Rodent Model;Role;Signal Transduction;standard of care;stem cell proliferation;Synapses;synaptic pruning;temozolomide;Testing;Therapeutic;Therapeutic Intervention;therapy design;Tissues;TLR4 gene;Transgenic Organisms;treatment response;tumor;tumorigenic

PROJECT_TITLE: Glial immune signaling in radiation-induced brain injury


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Immunotherapy;Infectious Diseases;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stomach Cancer

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Gastric (stomach) cancer is one of the top five causes of cancer and cancer deaths worldwide, and about 80% of cases are due to stomach infection with the bacterium Helicobacter pylori. This project will use new mouse models, human samples, and cutting-edge immune profiling and single-cell sequencing techniques to investigate the mechanism(s) through which chronic Helicobacter pylori infection and associated inflammation promote pre- cancerous changes in the stomach. This research will lead to a better understanding of how inflammation causes cancer and may reveal new immunotherapy strategies for infection-associated cancers.

PI_NAMEs: O'BRIEN, VALERIE PHOEBE (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Abnormal Cell;Acceleration;Alleles;Atrophic Gastritis;Bacteria;Bacterial Infections;Cancer Etiology;cancer immunotherapy;cancer risk;Carcinoma;Cell Line;Cell Lineage;cell transformation;cell type;Cells;Cessation of life;Chronic;Colorectal Cancer;congenic;Cytotoxin;Development;Disease;disease phenotype;Disease Progression;Dysplasia;Environment;experimental study;Gastric Acid;Gastric Chief Cells;Gastric Metaplasia;Gastric Parietal Cells;Gastritis;Gene Expression;Gene Expression Profile;Genes;genetic approach;Gland;Goals;Guanosine Triphosphate Phosphohydrolases;Helicobacter Infections;Helicobacter pylori;Human;Immune;Immune response;Immunity;immunopathology;Immunotherapy;In Situ Hybridization;Individual;Infection;Infiltration;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;insight;Intestinal Metaplasia;Intestines;KRAS2 gene;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Metaplasia;Modeling;Morphology;mouse model;MUC4 mucin;Mucous body substance;Mus;mutant;Mutation;Normal Cell;novel;Oncogenic;Pathway interactions;Peptidyltransferase;Phenotype;polarized cell;premalignant;Preneoplastic Change;prevent;progenitor;programs;Proliferating;protein expression;Protein Secretion;Proteins;PTPRC gene;repaired;Research;Role;Sampling;Series;Signal Pathway;Signaling Protein;single cell sequencing;single-cell RNA sequencing;Source;Splenocyte;stem cells;Stomach;Surface;T-cell inflamed;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;Tamoxifen;Techniques;Testing;Tissues;Toxin;Transgenic Organisms;tumor progression;Type IV Secretion System Pathway;Variant;Virulence;Virulence Factors

PROJECT_TITLE: Investigating gastric inflammation and preneoplastic progression driven by Helicobacter pylori infection

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Schizophrenia

PHR: Project Narrative Astrocytes are cells highly abundant in the brain where they play important roles in the maintenance of homeostasis. Recent evidence show that astrocytes are involved in neurological and neuropsychiatric disorders. Astrocytes have been reported to express the dopamine D2 receptors, a major player of the dopaminergic control of brain functions. This proposal aims at determining the role of D2R in astrocytes and possible implication in the control of brain disorders.

PI_NAMEs: BORRELLI, EMILIANA  (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Adult;Affect;Algorithms;American;Antibodies;Antipsychotic Agents;Astrocytes;Autoreceptors;Behavior;behavior test;behavioral impairment;Biochemical;Brain;brain control;Brain Diseases;Cell Separation;cell type;Cells;cellular imaging;Chronic;Cognitive;cognitive function;Data;Dendritic Spines;Diagnosis;Dissection;Dopamine;Dopamine D2 Receptor;Dopamine Receptor;Emotional;Etiology;experimental study;Fiber;Gene Expression;Genotype;Glial Fibrillary Acidic Protein;Goals;Histologic;Homeostasis;Human;imaging software;Immunofluorescence Immunologic;Impaired cognition;Impairment;improved;indexing;Injections;knock-down;Label;Link;LoxP-flanked allele;Maintenance;Mental disorders;Metabolic;metabolome;metabolomics;Microglia;Modeling;Molecular;morphological criteria;Morphology;mouse model;Mus;mutant;Nervous System Disorder;neural;Neurodevelopmental Disorder;Neuroglia;Neuroimmune;neuroinflammation;Neurons;neuropsychiatric disorder;novel;Pathologic;Pathway interactions;pharmacologic;Phenotype;Physiological;Play;Population;Prefrontal Cortex;Process;Proliferating;psychotic;receptor expression;Receptor Signaling;receptor-mediated signaling;Regulation;Reporting;Research;Role;Schizophrenia;severe mental illness;Short-Term Memory;Signal Transduction;single-cell RNA sequencing;Sorting;Symptoms;Synapses;Synapsins;Testing;Tissues;transcriptome;transcriptomics;Transfection;Up-Regulation;vector;Viral;Viral Vector;Virus

PROJECT_TITLE: Dopaminergic Control of Glial Cells in Prefrontal Cortex Functions

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Latinx families in the United States (US) are more likely to lose a child to cancer and experience inequities in bereavement and grief outcomes. This study will generate a comprehensive understanding of how the processes of adverse social determinants of health influence these inequities and how resilience could be leveraged to inform culturally and contextually grounded interventions for this population.

PI_NAMEs: BUZELLI, PATRICIA G. (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Acculturation;Address;adolescent health;Affect;Affective;Anxiety;Bereavement;cancer diagnosis;Capital;Cessation of life;Child;Childhood;contextual factors;coping;Data;data integration;design;Development;direct application;Elements;Ethnic Origin;experience;Face;Family;Family health status;Family member;Foundations;Future;Grief reaction;Health;health care availability;health equity;health equity promotion;health inequalities;Individual;Inequity;Intervention;Interview;Language;Latino;Latinx;Latinx population;Lived experience;loved ones;Malignant Childhood Neoplasm;Malignant Neoplasms;Measurement;Measures;Mental Depression;Mental Health;Methodology;Methods;mortality;National Institute of Nursing Research;Outcome;Parents;Pathology;Patient Self-Report;Pediatric Oncology;Personal Satisfaction;Population;Population Heterogeneity;Population Intervention;Post-Traumatic Stress Disorders;Posttraumatic growth;primary caregiver;Process;psychological distress;racial discrimination;Reaction;Reporting;Research;resilience;resilience factor;Resources;response;Risk;Shapes;social;social factors;social health determinants;Social isolation;social norm;social structure;Stress;Structure;United States

PROJECT_TITLE: Exploring Grief Through Social Determinants of Health Mechanisms Among Latinx Families in the US Who Are Living Through the Loss of a Child to Cancer: A Mixed Methods Study

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (89)]


PHR: PUBLIC HEALTH RELEVANCE The proposed studies will investigate mechanisms regulating endocytosis in Lysosome Rich Enterocytes (LREs) in zebrafish. These studies will provide valuable insights into the mechanisms controlling protein absorption in the vertebrate gut. Because LREs and their physiology are conserved between zebrafish and mammals our studies are relevant for human intestinal physiology, particularly infant nutrition and development.

PI_NAMEs: BAGNAT, MICHEL  (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: absorption;Actin-Binding Protein;Actins;Actomyosin;Adaptor Signaling Protein;amphiphysin;ANXA2 gene;Apical;apical membrane;Binding;Biological Assay;Biology;brush border membrane;Cells;Clathrin;Clathrin Adaptors;coated pit;Complex;Data;Dietary Proteins;Digestion;Electron Microscopy;Endocytosis;Enterocytes;Exhibits;F-Actin;Fishes;Genetic;genetic manipulation;Growth;Human;Image;in vivo;Infant Development;infant nutrition;insight;Intestines;intrinsic factor-cobalamin receptor;Kinetics;Knowledge;Length;Link;Lysosomes;Maintenance;Mammals;Mediating;Membrane;meter;Microscopy;Molecular;Morphogenesis;Motor;Mus;Myosin ATPase;Neonatal;novel;nutrient absorption;Outcome;pharmacologic;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Physiological;Physiology;Population;Process;Proteins;public health relevance;Publishing;recruit;Role;scaffold;scavenger receptor;segregation;Seminal;Spectrin;stem;Structure;System;Tertiary Protein Structure;Testing;Tubular formation;uptake;Vacuole;Vertebrates;Vesicle;Zebrafish

PROJECT_TITLE: Investigating Endocytic Mechanisms in Lysosome Rich Enterocytes

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]