ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The ability of cells to transit through different cellular states underlies many biological processes important for human health and disease. Cells can elicit state transitions by exerting control over gene expression. We propose to interrogate the fundamental mechanisms that modulate one layer of gene expression to drive cell state transitions in order to better understand how these programs function in healthy cells or may be hijacked during disease.

PI_NAMEs: HUTCHINS, ERICA  (contact)

PROJECT_TERMS: Automobile Driving;Biological Models;Biological Process;Biology;Candidate Disease Gene;Cells;Development;Disease;Epithelium;Fibrosis;Gene Expression;Genetic Transcription;Health;Human;Hybrids;Malignant Neoplasms;Mesenchymal;multiple omics;Natural regeneration;Neural Crest;Neural Crest Cell;novel;Pathologic;Post-Transcriptional Regulation;Process;programs;Residual state;RNA;RNA-Binding Proteins;Role;Testing;Transcript;Transcriptional Activation;transcriptome sequencing;wound healing

PROJECT_TITLE: Mechanisms of RNA turnover during the epithelial-mesenchymal transition

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences

ORG_CITY: STONY BROOK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: The proposed work will advance the TDA methodology development with application of multi-omics analysis. It will also advance our knowledge of cell-to-cell signaling and spatial layout of cellular components of microstructures in TM. The outcome will broadly impact many biomedical domains, such as cancer research, neuroscience, etc.

PI_NAMEs: CHEN, CHAO  (contact);JOHNSON, TRAVIS STEELE;ZHANG, JIE

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: anti-cancer research;Awareness;bioimaging;Cell Differentiation process;Cells;Collection;Complement;Data;Data Analyses;Development;disease diagnosis;Epithelial Cells;Foundations;Gene Activation;Gene Expression Profile;histological image;Histology;Image;Image Analysis;image visualization;imaging informatics;Immune;interest;Knowledge;learning algorithm;Maps;Methodology;Molecular;multiple omics;National Institute of General Medical Sciences;neural;Neuroglia;Neurons;Neurosciences;Normal tissue morphology;Outcome;Play;Prognosis;Research Personnel;Resolution;Role;Signal Transduction;single-cell RNA sequencing;Structure;Techniques;tissue mapping;Tissues;transcriptomic profiling;transcriptomics;tumor;whole slide imaging;Work

PROJECT_TITLE: DMS/NIGMS 1: Topological Study on Histological Images and Spatial Transcriptomics


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Prevention

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

ORG_STATE: CA

PHR: Project Narrative—Health Relevance The Caenorhabditis Intervention Testing Program has been established to identify pharmacological interventions that improve the length of life and/or the quality of aging. By testing genetically diverse animal models, this study seeks to identify interventions likely to be efficacious in a diverse human population. This study may ultimately lead to treatments that protect against physical deterioration, cognitive decline, and disease susceptibility in the elderly human population.

PI_NAMEs: LITHGOW, GORDON J (contact)

PROGRAM_OFFICER_NAME: FOX, JENNIFER THERESA

PROJECT_TERMS: Acceleration;Age;age-related disease;Aging;aging process;American;Animal Model;anti aging;Biological Assay;Biological Models;Biology of Aging;Caenorhabditis;Caenorhabditis elegans;Caregivers;Chemicals;Chronic Disease;Chronology;Clinical Research;Clinical Sciences;Collection;Communities;community setting;Data;Data Set;Databases;Dementia;design;Deterioration;Diabetes Mellitus;Disease;Disease susceptibility;Economics;efficacy testing;Elderly;Engineering;Evaluation;experimental study;extend lifespan;Gene Deletion;Gene Expression Regulation;Genes;Genetic;Genetic Drift;Genetic Heterogeneity;genome editing;Goals;hallmarks of aging;Health;Healthcare Systems;healthspan;healthy aging;Heart;Heterogeneity;Human;human old age (65+);Impaired cognition;Impairment;improved;Individual;innovation;Intervention;intervention program;Laboratories;late life;Life;life span;Link;Literature;Locomotion;Longevity;Maintenance;Malignant Neoplasms;Medical Research;Metabolism;Mitochondria;Modeling;mortality;Mus;Nematoda;Neurodegenerative Disorders;novel;Oregon;Outcome;Pathway interactions;Pattern;pharmacologic;Population;Population Heterogeneity;pre-clinical;pre-clinical research;Privatization;Process;programs;proteostasis;Quality of life;rate of aging;Recommendation;Reporting;Reproducibility;Research;Resistance;Resolution;response;Risk;Risk Factors;Science;screening;Signal Transduction;Societies;Stress;success;System;Systems Analysis;Testing;therapy development;transcriptome sequencing;Translating;Translations;Validation;Variant;Virus Diseases;whole genome;Work

PROJECT_TITLE: Caenorhabditis Intervention Testing Program - Buck Institute


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Fentanyl Misuse and Addiction;HIV/AIDS;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative HIV/AIDS continues to be a major global health issue. AIDS-related death has steadily decreased in recent years, but alarmingly, chronic liver disease has become a major cause of HIV-mortality. Several contributing factors are recognized including hepatotoxicity of anti-HIV drugs and widespread alcohol abuse. The likelihood of concurrent use of other addictive substances is high. The goal of the project is to provide mechanistic details on how these contributing factors interplay, validate biomarkers for efficacy/safety and adherence monitoring, and build strong foundations for developing mitigation strategies.

PI_NAMEs: BLACKARD, JASON T;BROWN, JENNIFER L;YAN, BINGFANG  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;AIDS prevention;Alcohol abuse;Alcohol consumption;alcohol use disorder;Alcohols;Anti-HIV Agents;Anti-viral Response;Apoptosis;Behavior;Behavioral;Biological Markers;biomarker validation;carboxylesterase;Carboxylesterase 1;Cells;Cessation of life;chemokine;chronic liver disease;co-infection;cytotoxicity;design;Diphosphates;drug metabolism;Ensure;Enzymes;Epidemic;Esterification;Ethanol;Exposure to;Fentanyl;Foundations;Free Radicals;Fumarates;General Population;global health;Goals;Health;Hepatitis Viruses;Hepatocyte;Hepatotoxicity;high risk;HIV;HIV Infections;HIV risk;HIV Seronegativity;HIV/AIDS;Human;Hybrids;Hydrolysis;In Vitro;in vivo;Incubated;Individual;Injections;Intervention;Link;Medicine;Metabolism;Monitor;mortality;multidisciplinary;Ohio;opioid mortality;Organ;originality;Oxidative Stress;Patients;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phosphorylation;pre-exposure prophylaxis;Prevalence;Prevention;preventive intervention;Prodrugs;receptor;Regimen;Research Design;Risk;Risk Behaviors;Safety;Sampling;single-cell RNA sequencing;stem;substance use;synthetic opioid;Technology;Tenofovir;Testing;Therapeutic;Time;Tissues;Toxic effect;transcriptome;transcriptome sequencing;transcriptomics;treatment adherence;treatment as prevention;Viral hepatitis;Viral Load result;virology

PROJECT_TITLE: Therapeutic and mechanistic significance of altered metabolism of HIV medicines by alcohol- or alcohol/synthetic opioid combination


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Immunotherapy;Lymphatic Research;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Many age-related neurodegenerative diseases—including Alzheimer's disease (AD)—are associated with misfolded protein deposition that promote inflammatory responses, neuronal dysfunction, and cognitive deficits. In this proposal we will address the hypothesis that aging immune cells (in particular, aging T lymphocytes) produce inflammatory molecule, IFN, which interacts with brain-draining lymphatic vessels in the borders of the brain and disrupts their function, subsequently leading to dysfunctional clearance of the brain's waste. We will assess the mechanism and therapeutic approaches to target this route as means to ameliorate Alzheimer's disease progression.

PI_NAMEs: KIPNIS, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: abeta deposition;Achievement;Acute;adaptive immune response;Address;Age;age related;age related decline;age related neurodegeneration;aged;Aging;aging population;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapy;Amyloid;Antibodies;Antigen Presentation;Antigens;Anxiety;Atlases;Attention;Attenuated;Behavior;Biological Markers;Blood Vessels;Brain;Brain Drains;brain dysfunction;brain parenchyma;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Count;Cell Physiology;Cell secretion;Cells;Central Nervous System;Cerebrospinal Fluid;Cognitive deficits;cytokine;Cytokine Signaling;Data;Deep Cervical Lymph Node;Deposition;Deterioration;Disease Progression;Drainage procedure;Equilibrium;Excision;Genetic Polymorphism;Genetic Transcription;genome wide association study;HLA-DR Antigens;IFNGR1 gene;IL17 gene;Immune;Immune response;Immunity;Immunotherapy;Impaired cognition;Impairment;Inflammatory;Inflammatory Response;Interferon Type II;Interleukin-4;Learning;Link;Lymphatic;lymphatic drainage;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic function;lymphatic vasculature;lymphatic vessel;Lymphocyte;Mediating;Memory;Memory impairment;Meningeal;Meningeal lymphatic system;Meninges;Microglia;misfolded protein;mouse model;Mus;Nervous System Disorder;neurogenesis;neuroinflammation;Neuronal Dysfunction;neutralizing antibody;new therapeutic target;novel;old mice;Outcome;overexpression;Pathologic;Pathology;Pathway interactions;Patients;Perfusion;Peripheral;Phase;Phenotype;Physiological;Population;preservation;prevent;Production;receptor;response;risk variant;Role;Route;Senile Plaques;Signal Transduction;single-cell RNA sequencing;Site;Source;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;Transgenic Mice;wasting

PROJECT_TITLE: Aged T-cell-derived cytokines impact meningeal lymphatics and contribute to AD


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: WORCESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative  The Innate Immunity Training Program proposed here is designed to educate the next generation of biomedical researchers in cutting-edge, high quality science. Innate immunity is of critical importance to several common human diseases including septic shock, heart disease (atherosclerosis), autoimmune diseases, and nearly all infectious diseases. Trainees will receive a comprehensive classroom-based foundation in innate immunity (and allied ﬁelds) upon which their laboratory research experience will build.

PI_NAMEs: SILVERMAN, NEAL  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Natural Immunity;Training Programs

PROJECT_TITLE: Innate Immunity Training Program

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Genetics

ORG_CITY: Nashville

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Subversion of DNA replication is an essential part of oncogenesis, and mutations in DNA replication proteins cause a variety of diseases (from cancer, to dwarfism, and even neurodegeneration), so it is critical for human health that we gain a complete understanding of how DNA replication works. This proposal will study how DNA replication is normally completed and the replication restart mechanisms that support completion of DNA synthesis. These processes are particularly important to understand because they involve several major tumor suppressors (e.g. BRCA1, BRCA2) and are targeted by chemotherapeutics (e.g. etoposide, olaparib, cisplatin).

PI_NAMEs: DEWAR, JAMES M (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;BRCA1 gene;BRCA2 gene;Bypass;Cell Cycle Checkpoint;chromosome missegregation;Cisplatin;Compensation;Defect;Disease;DNA;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair Pathway;DNA replication fork;ds-DNA;Dwarfism;Ensure;Etoposide;Event;Failure;Goals;Health;Human;insight;Malignant Neoplasms;Mitosis;Mitotic;Monitor;Mutation;Nerve Degeneration;novel strategies;Play;Process;Proteins;response;Role;Stress;Stretching;Therapeutic;Topoisomerase;Topoisomerase II;Tumor Suppressor Proteins;tumorigenesis;Work

PROJECT_TITLE: Mechanisms that ensure the completion of DNA synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: II. Narrative The proposed MADURA R25 Training Program combines thoroughly integrated, culturally relevant, group and individual mentorship experiences, training, outreach activities, professional development support, and paid MSTEM Aging and Alzheimer's disease research placements to UC San Diego Hispanic undergraduates. Its primary objective is to promote improved student academic success and retention in the near term, and subsequently, greater Hispanic inclusion in MSTEM Aging and Alzheimer's disease research, graduate education, and careers. The results, protocols and materials from this rigorously evaluated program will be broadly disseminated, benefitting diversity promotion efforts across aging-focused and broader public health education, research and clinical settings.

PI_NAMEs: EDLAND, STEVEN DYAL (contact);TRINIDAD, DENNIS RYAN

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Academic support;Aging;aging related;Agreement;Alzheimer's Disease;Awareness;career;Clinical;Collaborations;college;Cultural Backgrounds;Databases;deep field survey;design;Development;diversity and inclusion;Education and Outreach;Educational Curriculum;Elements;Employment;Environment;Evaluation;Event;evidence base;experience;Exposure to;Faculty;Fostering;Funding;Future;Generations;Genetic Research;Goals;Graduate Education;hands on research;high school;High School Student;Hispanic;Hispanic-serving Institution;Hour;improved;Income;Individual;Information Dissemination;innovation;Internships;Intervention;Knowledge;Laboratory Study;Latino;Leadership;Longitudinal cohort study;meetings;Mentors;Mentorship;Neurosciences;next generation;NIH Program Announcements;outreach;Ownership;peer;Positioning Attribute;Process;Program Development;Program Evaluation;programs;Protocols documentation;Public Health Education;Research;research faculty;Research Personnel;Schools;Services;skills;skills training;Social support;student mentoring;Students;success;Supervision;Support Groups;Touch sensation;Training;Training Activity;Training Programs;undergraduate research;undergraduate student;Underrepresented Students;Universities;Work

PROJECT_TITLE: The MADURA Program: Mentorship for Advancing Diversity in Undergraduate Research on Aging


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

PHR: 8. Project Narrative Humans are born with a limited pool of oocytes, which remain dormant for decades until they are recruited for ovulation as a fertilizable egg. The longer oocytes persist in this dormant state with increasing maternal age, they lose their competency to undergo embryonic development. This research seeks to better understand how oocytes are maintained in their dormant state, which will inform approaches for human assisted fertility.

PI_NAMEs: SWARTZ, STEVEN ZACHARY (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Address;Adult;Age;Aging;Aneuploidy;Animals;Biochemical;Biological;Biological Models;Cell Cycle;Cell Differentiation process;Cell division;Cells;Cellular biology;Chromosome Segregation;Chromosomes;Communication;Communities;Competence;Complex;Coupled;Cues;Development;Developmental Biology;developmental disease;Disease;egg;Embryo;Embryonic Development;Ensure;Environment;Female;Fertility;Fertilization;Future;Gene Expression Profile;Genes;Genetic Transcription;Genome;Goals;Growth;high throughput analysis;Hormonal;Human;Human Development;human tissue;In Vitro;Incidence;Kinetochores;knock-down;Knock-out;Length;Life Cycle Stages;Maintenance;male;Mass Spectrum Analysis;Maternal Age;Meiosis;Meiotic Prophase I;Mentors;Messenger RNA;metabolomics;Methods;Mitotic;Mitotic Spindle Apparatus;model organism;Modification;Molecular;molecular array;Multiplexed Analysis of Projections by Sequencing;mutant;Oocytes;Organism;Ovarian;Ovary;Ovulation;Patiria miniata;Phase;Physiological;Ploidies;Post-Translational Protein Processing;Process;Production;programs;Proliferating;Prophase;Proteins;Proteome;recruit;Regulatory Element;Reproduction;Research;Research Personnel;ribosome profiling;Series;Signal Transduction;Somatic Cell;sperm cell;Spontaneous abortion;Starfish;Stimulus;Supporting Cell;System;Techniques;Testing;Time;tissue culture;Training;Transcript;Translating;Vertebrates

PROJECT_TITLE: Molecular control of oocyte arrest, meiosis, and the transition to development

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Neurosciences;Opioid Misuse and Addiction;Opioids;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE People living with HIV (PLWH) are at the higher risk for impaired cognitive functions due to higher use of legal and illegal opioids that could affect their immune functions and exacerbate CNS (central nervous system) impairment. However, little is known about the HIV harboring cell types in brain, effect of therapy on specific CNS cell types, and the modification of brain functions by opioid use. Results of these innovative single-cell studies will generate cellular part list for brain regions and will illuminate novel insights into transcriptomic and epigenetic landscapes of CNS and how they are altered by HIV and opioid use.

PI_NAMEs: RANA, TARIQ M (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Agreement;Anatomy;Animal Model;antiretroviral therapy;Atlases;Autopsy;Binding;Bioinformatics;Biological Assay;Bipolar Disorder;Brain;brain cell;brain dysfunction;BRAIN initiative;Brain region;Cell Nucleus;cell type;Cells;Censuses;Central Nervous System;Cerebrum;Cessation of life;Chromatin;cognitive function;Data;data resource;Disease;DNA;Elements;Environment;Enzymes;Epigenetic Process;epigenome;epigenomics;exhaustion;frontal lobe;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Transcription;Genetic Variation;Genome;Glass;Hand;high risk;HIV;HIV Infections;HIV-associated neurocognitive disorder;HIV/AIDS;Human;Human Genome;Immune;immune function;Immune System Diseases;Immunobiology;Impaired cognition;Impairment;Individual;induced pluripotent stem cell;innovation;insight;Learning;Legal;Measurement;member;Methamphetamine;Methods;Modernization;Modification;Molecular;Morphology;Mus;National Institute of Drug Abuse;Neuroglia;neuroinflammation;novel;Nucleus Accumbens;Opioid;opioid use;opioid use disorder;Organoids;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phase;Physiology;Prefrontal Cortex;prevent;programs;Proteins;Rana;Regulator Genes;Regulatory Element;Reporting;Role;Sampling;Schizophrenia;single cell ATAC-seq;single cell sequencing;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;Specific qualifier value;System;Technology;Tissues;transcription factor;transcriptome;transcriptomics;Transposase;United States National Institutes of Health;Untranslated RNA;Validation;validation studies;Variant;Work

PROJECT_TITLE: Revealing the single cell determinants of brain relevant to persistent HIV infection and opioid use disorder


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Digestive Diseases - (Gallbladder);Genetics;Human Genome;Liver Cancer;Liver Disease;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE Intrahepatic cholangiocarcinoma (IHC) is a devastating, largely incurable cancer, with a rising worldwide incidence and few effective treatment options. The goals of this research project are to 1) establish the efficacy of hepatic arterial infusion of floxuridine (FUDR) combined with systemic chemotherapy for the treatment of unresectable IHC and 2) to use the unique collection of tissue, blood, and radiographic samples from trial patients to uncover biomarkers of clinical response.

PI_NAMEs: CERCEK, ANDREA ;IACOBUZIO-DONAHUE, CHRISTINE A;JARNAGIN, WILLIAM ROBERT (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;Adenocarcinoma;Area;arm;biliary tract;Biological Markers;Biology;Biopsy;Blood;Blood flow;CDKN2A gene;cell free DNA;Cells;chemotherapeutic agent;chemotherapy;Clinical;Clinical Trials;cohort;Collecting Cell;Collection;Combined Modality Therapy;Continuous Infusion;contrast enhanced computed tomography;Data;Diagnosis;Disease;Disease Management;Disease Progression;DNA analysis;DNA sequencing;Dose;Drug Screening;drug sensitivity;effective therapy;Enrollment;Evaluation;Evolution;Excision;FGFR2 gene;Floxuridine;Foundations;gemcitabine;Gene Mutation;Genes;genetic predictors;genetic signature;genomic data;Genomics;Geography;Goals;Hepatic;Hepatic artery;Heterogeneity;Image;improved;improved outcome;Incidence;Infusion procedures;Institution;intrahepatic;Intrahepatic Cholangiocarcinoma;KRAS2 gene;Laparoscopy;Liver;Local Therapy;Malignant Neoplasms;Methods;Modality;Modeling;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;multimodality;Mutation;neoplastic cell;novel;Oncology;Operative Surgical Procedures;Organoids;Outcome;oxaliplatin;Pathogenesis;patient population;patient stratification;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Peripheral;peripheral blood;Pharmaceutical Preparations;Phase;phase 2 study;Phase II Clinical Trials;Platinum Compounds;Positive Lymph Node;precision medicine;Prediction of Response to Therapy;predictive marker;primary endpoint;Primary Neoplasm;Prognosis;prognostic;Progression-Free Survivals;prospective;protein expression;Pump;quantitative imaging;Radiogenomics;radiological imaging;radiomics;Randomized;Recurrence;Regimen;Regional Chemotherapy;Reporting;Research;Research Project Grants;Resistance;response;Risk Factors;risk stratification;Sampling;Site;Solid Neoplasm;Source;Specimen;Staging;standard care;subclonal heterogeneity;Systemic Therapy;targeted exome sequencing;targeted sequencing;targeted treatment;Techniques;Testing;therapeutic target;therapy resistant;Time;Tissue Banks;Toxic effect;TP53 gene;Treatment Failure;Treatment outcome;Treatment Protocols;treatment response;treatment strategy;tumor;tumor DNA;tumor heterogeneity;Unresectable;Vascular blood supply;Work;X-Ray Computed Tomography

PROJECT_TITLE: Improving Outcome in Patients with Advanced Intrahepatic Cholangiocarcinoma: A Randomized Phase II Study of Gemcitabine and Oxaliplatin With or Without Regional Floxuridine (FUDR)

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

PHR: PROJECT NARRATIVE The Integrated Training Program in Diabetes, Endocrinology and Metabolism (DEM) enhances research training in Endocrinology and Metabolism at University of California San Francisco (UCSF) by supporting didactic education, mentored research experience and career mentoring for scientists in training. Research performed by scientists trained through the UCSF DEM Program contributes to our understanding of endocrine and metabolic diseases and to improvements in the lives of people suffering from these disorders.

PI_NAMEs: HSIAO, EDWARD C (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: Diabetes, Endocrinology & Metabolism Training Grant

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Lewy Body Dementia;Neurodegenerative;Neurosciences;Pain Research;Palliative Care;Parkinson's Disease

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative: Neurodegenerative illnesses such as Parkinson’s (PD) and Alzheimer’s disease (AD) affect nearly 15% of adults over age 65, are associated with reductions in patient and caregiver quality of life, and represent two of the leading causes of death in the US. There is an emerging body of research that applying palliative care approaches may help improve the quality of life of patients and families affected by neurodegenerative illnesses by addressing potential causes of suffering including pain, psychosocial issues and spiritual needs. As palliative care approaches are new to the field of neurology the present application is designed to provide necessary training and research experiences to allow the candidate to lead efforts to advance the development, testing, implementation and dissemination of palliative care approaches to improve outcomes for patients and families affected by neurodegenerative illnesses.

PI_NAMEs: KLUGER, BENZI M (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Address;Administrative Supplement;Adult;Advance Care Planning;Advanced Development;Affect;aging in place;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Area;Award;burnout;care systems;career;career development;caregiver quality of life;Caregiver support;Caregivers;Caring;Cause of Death;Chronic;Communities;community setting;comparative effectiveness trial;Data;design;Development;Dissemination and Implementation;Distress;Education;effectiveness evaluation;effectiveness testing;efficacy trial;Elderly;end of life care;experience;Family;Fostering;Foundations;Funding;Future;Goals;Grant;Health Care Costs;health care disparity;Health Policy;Home visitation;human old age (65+);implementation science;improved;improved outcome;Individual;interest;Intervention;Interview;Lead;Leadership;Lewy Body Dementia;Life;Malignant Neoplasms;Medical;medical specialties;meetings;Mental Depression;Mentors;Modeling;Neurodegenerative Disorders;Neurologic Symptoms;Neurologist;Neurology;novel;novel strategies;Nursing Homes;older adult;online community;Outcome;Outpatients;Pain;Pain management;palliative;Palliative Care;Parkinson Disease;patient mobility;Patient-Focused Outcomes;Patients;Personality;physical symptom;Physicians;Play;Population;preference;Program Research Project Grants;programs;psychiatric symptom;psychosocial;Psychosocial Influences;Quality of life;randomized trial;randomized, clinical trials;Research;Research Personnel;Resources;Role;satisfaction;Services;Site;Specialist;Spirituality;stem;Symptoms;Teleconferences;telehealth;Testing;Time;Training;Transportation;Transportation of Patients;Universities;virtual;Work

PROJECT_TITLE: Advancing Palliative Care for Older Adults Affected by Neurodegenerative Disease: Parkinsons disease, Alzheimers disease and Related Dementias

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ORG_CITY: SEATTLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative We have found that the DNA sensor cGAS, long thought to be a cytosolic protein, is a tightly tethered nuclear protein that is carefully regulated to prevent detection of self-DNA. We will define how nuclear tethering prevents cGAS autoreactivity and enables it to respond to foreign DNA.

PI_NAMEs: STETSON, DANIEL B (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Amino Acids;Applications Grants;Autoimmune Diseases;autoreactivity;Base Pairing;Biology;Biotinylation;Cell Cycle;Cells;Chimeric Proteins;Chromatin;Cytosol;Detection;Discrimination;DNA;DNA Virus Infections;DNA Viruses;Genomic DNA;Host Defense;Human;Human Cell Line;Infection;innovation;insight;Knock-in Mouse;Label;Ligands;Mediating;mouse model;Mus;Mutation;Nature;new therapeutic target;Nuclear;Nuclear Protein;Nucleic Acids;Pathway interactions;Phase;prevent;Proteins;Regulation;Resistance;response;Rest;RNA;sensor;Sodium Chloride;Stimulator of Interferon Genes;Surface;temporal measurement;tool;Tumor Immunity;Untranslated RNA;Viral Proteins;Virus Diseases

PROJECT_TITLE: Regulation and Function of Nuclear cGAS

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The Kinshasa School of Public Health - University of North Carolina Research Partnership is the ideal team to continue as a research unit in the Eunice Kennedy Shriver NICHD Global Network for Women’s and Children’s Health Research. Our overall goal is to discover evidenced-based strategies to improve health outcomes in low and middle-income countries. To achieve this goal, we will: 1) execute high-quality studies with early identification of pregnancies, rigorous tracking of outcomes and follow-up rates >90%, 2) support the Global Network with innovative trials and trial designs, and 3) strengthen research infrastructure in the DRC and develop the next generation of research leaders.

PI_NAMEs: BAUSERMAN, MELISSA SCHWEIKHART (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Anthropometry;Area;Child;Child Health;Child Mortality;clinical implementation;Clinical Research;Clinical Trials;Communicable Diseases;Communities;community based research;cost effective;Country;Death Rate;Democratic Republic of the Congo;Development;Discipline of obstetrics;early childhood;Early identification;effective intervention;Enrollment;Ensure;Environment;Epidemiology;Evaluation;evidence base;experience;Faculty;follow-up;Gestational Age;global health;Goals;Gynecology;Health;implementation science;improved;improved outcome;Incubators;innovation;International;Intervention;intrapartum;Laboratories;Location;low and middle-income countries;low income country;Manuscripts;Maternal and Child Health;Maternal Health;Maternal Mortality;Methodology;mHealth;Mission;Modeling;mortality;Multi-Institutional Clinical Trial;multidisciplinary;National Institute of Child Health and Human Development;Neonatal;neonatal encephalopathy;neonatal health;Neonatal Mortality;Neonatology;next generation;North Carolina;nutrition;Observational Study;Outcome;Paper;Performance;peri-urban;perinatal medicine;Pharmacology;poor health outcome;Positioning Attribute;Poverty;Pregnancy;Pregnancy Outcome;prenatal;Productivity;Protocols documentation;public health research;Public Health Schools;Publishing;Reporting;Research;Research Infrastructure;Research Methodology;Research Proposals;research study;Resource-limited setting;Resources;Role;Rural;Site;Sustainable Development;therapy design;Training;trial design;Tropical Medicine;ultrasound;United Nations;Universities;Urban Community;urban setting;Vulnerable Populations;Woman;women's outcomes

PROJECT_TITLE: The University of North Carolina-Kinshasa School of Public Health Research Partnership in the Democratic Republic of Congo; a Model for Improving Women's and Children's Health Through Research


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project narrative Despite promising new therapeutics, lung cancer remains a devastating disease and is the top cause of cancer mortality. We and others recently showed that a a protein named SMARCA2 is essential for growth of a subtype of lung cancer and discovered a potent chemical molecule that degrades this protein. In this proposal, we aim to perform in depth biological studies to better understand the mechanism of the growth inhibitory activity of SMARCA2 degradation using chemical biology and genetic approaches as well as explore the therapeutic potential of SMARCA2 degradation by our molecule in such tumors.

PI_NAMEs: LISSANU, YONATHAN  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Ablation;analog;ARID1A gene;Biological;Biological Models;Biology;Cancer Biology;cancer cell;Cancer Cell Growth;Cancer cell line;Cancer Etiology;cancer subtypes;Cells;Chemicals;Chromatin;Chromatin Remodeling Factor;clinical development;clinical translation;Complex;CRISPR/Cas technology;Data;Development;Disease;drug mechanism;efficacy testing;Epidermal Growth Factor Receptor;Epigenetic Process;experimental study;Foundations;Frequencies;Future;Gene Expression;Gene Targeting;Genes;Genetic;genetic approach;Genetically Engineered Mouse;Genomics;Goals;Growth;Heterozygote;Immunotherapy;improved;In Vitro;in vivo;inhibitor;insight;interest;Knowledge;Lead;loss of function;lung cancer cell;Malignant neoplasm of lung;Mediating;mortality;Mus;mutant;Mutate;Mutation;Names;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Pathway interactions;patient derived xenograft model;Patients;Pharmacodynamics;Positioning Attribute;pre-clinical;preclinical development;programmed cell death ligand 1;Protac;Proteins;Reporting;Resistance;resistance mechanism;Role;small molecule;SMARCA2 gene;SMARCA4 gene;Sucrose;targeted treatment;Technology;Therapeutic;Therapeutic Index;therapeutic target;therapeutically effective;tumor;tumor growth;Validation;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeting SMARCA2 as a therapeutic strategy in SMARCA4 mutant lung cancer


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Duchenne/ Becker Muscular Dystrophy;Muscular Dystrophy;Pediatric;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE We have developed new animal models and assays to elucidate the contribution of microtubule disorganization to the pathogenesis of Duchenne muscular dystrophy. We have also established state-of-the-art methods to perform the first ever side-by-side mechanical comparison of single dystrophin and utrophin molecules. Our proposed studies will provide new understanding into the functions of dystrophin and utrophin in healthy muscle, and will inform on the potential for miniaturized dystrophins and utrophin to functionally replace full-length dystrophin as therapeutic approaches for Duchenne muscular dystrophy.

PI_NAMEs: ERVASTI, JAMES M (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Ablation;Actins;Affect;Affinity;Animal Model;Atomic Force Microscopy;Bacteria;Becker Muscular Dystrophy;beta Actin;Binding;Binding Sites;Biochemical;Biological Assay;Cells;Complex;Coupling;Cytoplasm;Cytoskeleton;Data;Development;Duchenne muscular dystrophy;Dystrophin;dystrophinopathy;experimental study;Functional disorder;Funding;gamma Actin;gene therapy;Glycoproteins;Goals;In Vitro;Insecta;Investigation;Knockout Mice;Length;Link;mdx mouse;Measures;mechanical behavior;mechanical properties;Mechanical Stress;Mechanics;Methods;micro-dystrophin;Microfilaments;Microtubules;mini-dystrophin;miniaturize;Modeling;monomer;Mus;Muscle;Muscular Dystrophies;Myoblasts;novel;overexpression;Pathogenesis;Pathology;Pathway interactions;Phenotype;Post-Translational Protein Processing;Proteins;Publications;Publishing;Reactive Oxygen Species;Recombinant Proteins;Recombinants;Sarcolemma;Side;Skeletal Muscle;Spectrin;Striated Muscles;Structure;System;Therapeutic;Transgenic Organisms;Utrophin

PROJECT_TITLE: Cytoskeletal Interactions of Dystrophin

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Kidney Disease;Machine Learning and Artificial Intelligence;Organ Transplantation;Transplantation

ORG_CITY: HADLEY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Narrative This project will yield an expected outcome of intelligent OCT imaging technology that can increase the number of healthy kidneys available for transplantation by making the most efficient use of available donor kidneys, eliminate the possible use of bad donor kidneys (i.e., excessively damaged ischemic or diseased kidneys), provide a measure of expected post-transplant renal function, and allow better distinction between post- transplant immunological rejection and ischemic induced acute renal failure. This technology is uniquely suited for transplant kidney, and no alternative is currently available in clinics. Such a technology promises to improve the efficacy of transplantation, enhance the life quality of ESRD patients, and significantly reduce the ESRD healthcare burden.

PI_NAMEs: POTTER, STEVEN ;TANG, QINGGONG ;ZHANG, HAICHONG ;ZHANG, XIAOHUI  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: 3-Dimensional;Acute Kidney Failure;algorithm development;Algorithms;Anatomy;Area;Biological;Biopsy;Cessation of life;Clinic;Clinical;Clinical Research;cohort;Collaborations;Data;deep learning;deep learning model;delayed graft function;Device or Instrument Development;Devices;Diabetes Mellitus;diagnostic criteria;Diameter;Discrimination;Donor person;End stage renal failure;Failure;functional status;Generations;Goals;graft failure;graft function;Guidelines;healthcare burden;high resolution imaging;high risk;Histologic;Histology;Histopathology;Human;human imaging;Hypertension;Image;image processing;Imaging Device;imaging study;Imaging technology;Immunologics;implantation;improved;In Situ;indexing;Ischemia;Kidney;Kidney Diseases;kidney imaging;Kidney Transplantation;Location;Maps;Measures;Medical center;Medical History;Methods;Morphology;Nephrology;novel;Oklahoma;Operating Rooms;Operative Surgical Procedures;Optical Coherence Tomography;Organ Donor;Organ Procurements;Organ Transplantation;Outcome;Pathologic;Pathology;Patients;post-transplant;predictive modeling;Procedures;Process;prognostic;prospective;Quality of life;Renal function;Resolution;Risk;robot assistance;Robotics;Sampling;Scanning;screening;Site;Specificity;Surface;System;Technology;Testing;Time;Tissues;tool;training data;Translating;Transplantation;Tubular formation;Uncertainty;Validation;virtual;Visual;Waiting Lists;Weight

PROJECT_TITLE: Automatic Wide-Field Optical Coherence Tomography for Assessment of Transplant Kidney Viability

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Heart failure with preserved ejection fraction (HFpEF) and coronary microvascular dysfunction (CMD) are prevalent conditions that predominantly impact women, while no targeted therapies for HFpEF exist. The application will test the hypothesis that chronic CMD-related ischemia results in an intra-cardiomyocyte metabolic shift leading to myocardial steatosis and pre-HFpEF traits using comprehensive cardiac magnetic resonance (CMR) imaging, CMR spectroscopy and inflammatory eicosanoid profiling. Understanding the role of cardiac steatosis in CMD and HFpEF promises to reveal novel targets for preventing and treating HFpEF, especially in women.

PI_NAMEs: WEI, JANET  (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: adjudication;Affect;Animal Model;Aorta;Automobile Driving;Blood Vessels;Cardiac;cardiac magnetic resonance imaging;Cardiac Myocytes;Cardiovascular system;Caring;Chronic;Clinical;clinical phenotype;Clinical Trials;cohort;Communities;Coronary;Coronary Arteriosclerosis;Data;Development;Diagnosis;Diffuse;Disease Progression;EFRAC;Eicosanoids;Electrocardiogram;experience;Family;fatty acid oxidation;Fibrosis;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Functional disorder;Glucose;Healthcare Systems;Heart;Heart Atrium;Heart failure;high throughput analysis;Human;Impairment;indexing;Inflammation;Inflammatory;Ischemia;Left;Left Ventricular Remodeling;Lipids;Magnetic Resonance;Magnetic Resonance Spectroscopy;Mass Spectrum Analysis;Measures;Mechanics;Mediating;Mediator;men;Metabolic;Methods;Microvascular Dysfunction;Monitor;Myocardial;Myocardial Ischemia;Myocardium;Nonesterified Fatty Acids;novel;novel therapeutics;offspring;Outcome;Pathway interactions;Perfusion;Phenotype;phenotypic data;Plasma;pre-clinical;preservation;Prevalence;prevent;Process;Prospective cohort;Research Personnel;response;Risk;Role;Specificity;Spectrum Analysis;stressor;systemic inflammatory response;targeted treatment;Testing;Tissues;trait;Triglycerides;Ventricular;Woman;women's outcomes

PROJECT_TITLE: Myocardial Steatosis in Women with Coronary Microvascular Dysfunction: Defining the Pathway to Heart Failure with Preserved Ejection Fraction (HFpEF)

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: The microglia surfaceome serves as a critical cellular hub that enables neuroprotective, neurotoxic, and neuroinflammatory signaling in the diseased brain. The ability to precisely target and manipulate diverse microglia states and function therefore holds tremendous experimental and therapeutic potential. The proposed project will use innovative tools and technologies to mechanistically interrogate and modulate microglia phagocytosis in Alzheimer’s disease and thus holds important therapeutic implications for treating this devastating disorder.

PI_NAMEs: HOLMES, BRANDON BLAKE (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;American;Amyloid;Amyloid beta-Protein;Amyloid Proteins;Antibodies;antibody engineering;Autopsy;beta amyloid pathology;Binding;Biological;Biological Assay;Biology;Bispecific Antibodies;brain cell;Brain Diseases;brain tissue;California;career;Cell Culture Techniques;Cell fusion;Cell surface;Cell Surface Proteins;Cell Surface Receptors;Cells;Complex;Core Protein;CRISPR-mediated transcriptional activation;Data;Data Set;design;Disease;Disease associated microglia;Disease Progression;Disease susceptibility;drug discovery;Engineering;Environment;Epigenetic Process;epigenomics;Exhibits;exosome;Exposure to;extracellular;Funding;Future;Genes;Genetic Transcription;genetic variant;genome wide association study;glycoproteomics;Glypican;Goals;Heparan Sulfate Proteoglycan;Human;human induced pluripotent stem cells;Immune;Immunohistochemistry;induced pluripotent stem cell;Inflammatory;innovation;interest;Invaded;Investigation;Knowledge;Link;live cell imaging;Lysosomes;Malignant Neoplasms;Mass Spectrum Analysis;Mediator;Mentors;Methods;Microglia;Modeling;Molecular;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuroprotection;Neurosciences;neurotoxic;novel;novel therapeutics;Outcome;pathogen;Pathogenesis;Pathologic;Pathology;Pathway Analysis;Pattern;Phagocytosis;pharmacologic;Physicians;Process;Proteins;proteoglycan core protein;Proteome;Proteomics;Reaction;receptor;Recombinant Antibody;Recombinants;Reporter;Research;Research Personnel;response;response to injury;Role;Route;San Francisco;Scientist;Senile Plaques;Signal Transduction;Surface;tau aggregation;tau Proteins;Technology;Testing;Therapeutic;Therapeutic Agents;Tissues;tool;Toxin;Training;TREM2 gene;Universities;Up-Regulation;uptake;Work

PROJECT_TITLE: Interrogating and Targeting Microglia Phagocytosis in Alzheimer’s Disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


PHR: PROJECT NARRATIVE Patients with kidney disease suffer major metabolic abnormalities, which can be life-threatening. Part of this effect may be due to so-called uremic toxins. Our studies will help define how a certain drug transporter, OAT1, regulates whole body and organ metabolism in the setting of kidney disease. This could set the stage for new therapies designed to circumvent the loss of OAT1 function in kidney disease.

PI_NAMEs: NIGAM, SANJAY K (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: Affect;Anions;Anti-viral Agents;Antibiotic Therapy;Antibiotics;Avena sativa;Bacterial Genes;Bile Acids;Binding Proteins;Biochemical Pathway;Blood;Brain;Chronic Kidney Failure;Citric Acid Cycle;cofactor;Communication;Data;Data Set;design;differential expression;Disease;disease model;Diuretics;drug discovery;experience;Feces;Genes;genome sequencing;genome-wide;gut bacteria;gut dysbiosis;gut microbes;gut microbiome;gut microbiota;host microbiota;Human;improved;In Vitro;in vivo;Kidney;Kidney Diseases;Knock-out;Knockout Mice;Life;lipid metabolism;Lipids;Liver;Maps;Mediating;Metabolic;Metabolism;metabolomics;Metagenomics;Methods;Microbe;microbial genome;microbiome;Modeling;multi-scale modeling;Mus;Nature;Nephrectomy;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutics;operation;Organ;Organic Anion Transport Protein 1;Organic Anion Transporters;Organism;Paper;Pathway Analysis;Pathway interactions;Patients;Pharmaceutical Preparations;Physiology;Plasma;Proximal Kidney Tubules;Publishing;reconstruction;remote sensing;Renal function;Residual state;Rodent;Role;Sampling;Serum;Signal Transduction;small molecule;solute;Syndrome;System;theories;therapy design;Tissues;Toxic effect;Toxin;transcriptomics;Tryptophan;Tryptophan Metabolism Pathway;Tubular formation;Uremia;Vitamins;whole genome;Work

PROJECT_TITLE: The Role in OAT1 in Uremia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-W(05)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prostate Cancer;Social Determinants of Health;Urologic Diseases

ORG_CITY: DURHAM

ORG_DEPT: UROLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Numerous systemic therapies have been approved for the treatment of advanced prostate cancer; while little comparative effectiveness data exists on these therapies, there are substantial price differences. These high drug prices often result in significant patient financial burden with devastating consequences: poor adherence and worse outcomes. The overarching goal of this proposal is to understand the economic and non-economic factors that determine the choice of first-line systemic therapy for advanced prostate cancer, and to design and pilot test an intervention aimed at decreasing patient out-of-pocket payments for prostate cancer care.

PI_NAMEs: KAYE, DEBORAH R. (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: acceptability and feasibility;Adherence;advanced prostate cancer;Affect;arm;Award;Awareness;cancer care;Cancer Patient;care providers;career;career development;Clinic;Clinical;clinical infrastructure;Clinical Trials Design;Combined Modality Therapy;comparative effectiveness;cost;cost outcomes;Data;Decision Making;Dedications;design;Development;Development Plans;Disparity;docetaxel;Economics;Ensure;experience;feasibility testing;Financial cost;Financial Hardship;financial toxicity;Focus Groups;Foundations;Goals;Guidelines;Health Policy;Health Services;improved;improved outcome;Income;informant;Insurance Carriers;Intervention;intervention refinement;Intervention Trial;Interview;iterative design;Knowledge;Location;Malignant neoplasm of prostate;Malignant Neoplasms;medical specialties;medication compliance;Mentors;Nurses;Oncologist;Outcome;Patient Care;patient oriented;Patient Preferences;Patient-Focused Outcomes;Patients;payment;Pharmaceutical Preparations;Pharmacists;Physicians;pilot test;pilot trial;Policies;preference;Price;Process;Prostate;Prostate Cancer therapy;Provenge;Provider;provider behavior;Qualitative Methods;Qualitative Research;Race;Randomized;Randomized, Controlled Trials;Recommendation;Research;Research Methodology;Research Personnel;Review Literature;Route;rural area;Scientist;side effect;Signal Transduction;Social Workers;Southeastern United States;Surgeon;Surveys;Systemic Therapy;Testing;therapy design;Treatment outcome;Uninsured Medical Expense;urban area;urologic;usability;Work

PROJECT_TITLE: Improving outcomes of patients with advanced prostate cancer through a better understanding of provider decision-making

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Aging;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Kidney Disease;Neurosciences;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Prostate cancer is the most common non-skin cancer among men and androgen deprivation therapy is an effective mainstay treatment that has greatly reduced mortality related to primary cancer. However, men who undergo androgen deprivation therapy are more likely to develop hypertension and die from cardiovascular diseases than men who are treated for prostate cancer without the use of androgen deprivation therapy. Therefore, I am seeking to determine the neural and renal contributions to hypertension in men who undergo androgen deprivation therapy, as well as the mechanistic influence of inflammation on these outcomes.

PI_NAMEs: BABCOCK, MATTHEW C (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Accounting;Acute Renal Failure with Renal Papillary Necrosis;Adverse effects;Affect;Agonist;American;androgen deprivation therapy;Androgen Receptor;Androgen Suppression;Androgens;arm;aspirate;Baroreflex;Biological Markers;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure regulation;blood pressure variability;Brain Stem;Cancer Survivor;Cancer Survivorship;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;career development;Cause of Death;Cessation of life;Circulation;Clinical;Colorado;cytokine;Data;Development Plans;Diagnosis;Distal;Doctor of Philosophy;Effectiveness;Environment;Exercise;experience;fatty acid-binding proteins;Functional disorder;Funding;Future;Glomerular Filtration Rate;Goals;Gonadal Steroid Hormones;Gonadotropin Hormone Releasing Hormone;Growth;Heart Rate;Hormones;Human;Hypertension;IL18 gene;Impaired Renal Function;Impairment;improved;Individual;Inflammation;Inflammatory;inhibitor;insight;Interleukin-6;Isometric Exercise;Kidney;Kidney Diseases;kidney dysfunction;kidney vascular structure;LCN2 gene;Liver;Longitudinal Studies;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medical;Medical Oncologist;meetings;men;Mentors;Mentorship;Metastatic Prostate Cancer;Microinjections;middle age;modifiable risk;mortality;multidisciplinary;Nerve;neural;neural circuit;Neuronal Dysfunction;Neurophysiology - biologic function;neuroregulation;Observational Study;older men;Outcome;Patients;Physiology;Placebo Control;Placebos;Population;Pre-Clinical Model;professor;prostate cancer survivors;Prostate Cancer therapy;Proteomics;Randomized Controlled Clinical Trials;rat KIM-1 protein;Rattus;Receptor Inhibition;Recording of previous events;recruit;Reflex action;Renal Blood Flow;Renal function;Renal Plasma Flow;Research;Research Design;Research Personnel;Resistance;response;Risk;Rodent;Role;Scientific Advances and Accomplishments;Secure;side effect;skills;Survival Rate;System;Technical Expertise;Testing;Testosterone;Time;Training;Translating;Tubular formation;Universities;Vascular resistance;vasoconstriction;Work

PROJECT_TITLE: Neural and Renal Contributions to Hypertension with Androgen Deprivation Therapy

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The goal of this project is to define the biological fate of low risk (Grade Group 1) prostate cancer in both African and European Americans. This project will allay patient concerns related to disease progression and the presence of co-existing higher-grade cancer—factors that play central roles in the safe and effective implementation of surveillance. Ultimately, findings from this research will enhance patient selection for surveillance and inform how to improve the quality of its implementation.

PI_NAMEs: SALAMI, SIMPA SAMUEL (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Address;African;African American;African American population;American;Archives;Area;Autopsy;Bioinformatics;bioinformatics pipeline;Biological;Biological Markers;Biology;Biopsy;Biopsy Specimen;black patient;Black Populations;Cessation of life;Clinical;Clinical Management;Clonality;cohort;Coupled;Data;Diagnosis;Diagnostic tests;Disease;Disease Progression;disorder risk;Distant Metastasis;DNA Sequence Alteration;Equilibrium;European;follow-up;Formalin;Goals;High-Risk Cancer;Immunohistochemistry;implementation barriers;improved;Incidence;Individual;Knowledge;Light;Link;Lymph Node Involvement;lymph nodes;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metastatic Neoplasm to Lymph Nodes;Methods;Molecular;Molecular Profiling;Monitor;mortality;Natural History;Nature;Neoplasm Metastasis;next generation sequencing;Outcome;Paraffin Embedding;Patient Selection;Patients;Periodicals;Physicians;Pilot Projects;Play;prospective;Prospective cohort;Prostate;prostate biopsy;prostate cancer risk;Prostatectomy;Prostatic;Provider;Quality of life;racial disparity;racial diversity;Radical Prostatectomy;Research;Risk;Role;Sampling;Serum;Specimen;Surface Antigens;surveillance strategy;Techniques;Technology;Testing;Time;tissue resource;Tissues;trait;transcriptomic profiling;transcriptomics;tumor;tumor progression;ultrasound;Uncertainty;United States;Work

PROJECT_TITLE: Defining the Biological Arc of Grade Group 1 Prostate Cancer


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Radiation Oncology;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE The studies proposed herein will determine the impact of BCL2, a protein that supports the survival of cancer cells responding to treatment, on the immunological configuration of hormone receptor (HR)+ breast cancer (BC), as well as the therapeutic value of combining radiation therapy (RT) with BCL2 inhibitors in immunocompetent mouse models of HR+ BC. These findings will provide preclinical ground to the initiation of clinical trials testing RT plus venetoclax (a BCL2 inhibitor currently approved by regulatory agencies for use in patients with chronic lymphocytic leukemia) in women with HR+ BC, a type of BC that still affects >200,000 and kills >25,000 new women every year in the US.

PI_NAMEs: GALLUZZI, LORENZO  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Affect;anti-cancer;Apoptotic;Attention;BCL2 gene;Biological Assay;Biopsy;Breast Cancer Cell;Breast Cancer Patient;cancer cell;Cancer Etiology;cancer survival;CD8-Positive T-Lymphocytes;Cell Membrane Permeability;Cells;Cessation of life;Chemotherapy and/or radiation;Chronic Lymphocytic Leukemia;Clinical;Clinical Management;Clinical Trials;Clinical Trials Design;clinically relevant;combinatorial;Competence;Coupled;Cytosol;Data;Diagnosis;Diagnostic;Disease;disease model;Dose;ds-DNA;Enzyme-Linked Immunosorbent Assay;Exhibits;FDA approved;Flow Cytometry;FOXP3 gene;Genetic;Goals;Hormone Receptor;hormone receptor-positive;Human;human disease;Immune;immune cell infiltrate;immune checkpoint;immune checkpoint blockers;Immune response;Immune Targeting;Immunocompetent;immunodeficiency;immunogenicity;Immunologics;Immunotherapy;In Vitro;in vivo;Infiltration;inhibitor;innovation;Interferon Type I;Knock-out;Link;Malignant Breast Neoplasm;Methods;MHC Class I Genes;Microscopy;Mitochondria;Mitochondrial DNA;mitochondrial membrane;Modeling;mouse model;Mus;novel strategies;overexpression;Patients;pharmacologic;pre-clinical;preservation;prevent;Process;programmed cell death ligand 1;programmed cell death protein 1;Proteins;radiation effect;radiation response;Radiation therapy;Radiation Tolerance;Regimen;Regulation;Regulatory T-Lymphocyte;research clinical testing;Resistance;resistance mechanism;Role;Signal Transduction;single-cell RNA sequencing;standard care;Testing;Therapeutic;therapy resistant;tool;transcriptomics;Translating;Translations;Treatment Efficacy;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;virtual;Woman;XCR1 gene

PROJECT_TITLE: Targeting the BCL2 immune checkpoint to enhance the immunostimulatory effects of radiation in breast cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Postpartum hemorrhage occurs when the uterus bleeds excessively after childbirth and is often caused by failure of the uterus to contract properly. This study uses non-invasive genetic biomarkers to determine how well the uterus will respond to oxytocin, a common medication used during childbirth to help uterine contraction and treat hemorrhage. The biomarkers will allow us to develop new ways to predict risk for hemorrhage before birth and design treatments that are more effective, thereby saving mothers’ lives and minimizing long-term health problems.

PI_NAMEs: ERICKSON, ELISE N (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Address;Affect;African;Arizona;Asian population;Binding;Biological Markers;Biosocial;Birth;Blood;Blood specimen;Blood Transfusion;Case/Control Studies;Cesarean section;Childbirth;Clinical;Clinical Assessment Tool;clinical biomarkers;clinical decision-making;clinical predictors;Complication;Contracts;Data;data repository;Data Set;Databases;desensitization;Disadvantaged;disease phenotype;Disparity;DNA;DNA Methylation;DNA Modification Process;dosage;Dose;Early identification;Electronic Health Record;Emergency Situation;Environment;epigenetic marker;Epigenetic Process;epigenetic variation;Ethnic Population;experience;Failure;Family;First Births;Foundations;Gene Expression;Genes;Genetic;Genetic Markers;genetic testing;genetic variant;Genetic Variation;Genotype;Goals;Health;health inequalities;Health Surveys;Hemorrhage;high risk;Hispanic;Hormones;Hour;improved;In Vitro;Individual;Induced Labor;innovation;Institute of Medicine (U.S.);Intervention;Investigation;Labor Onset;Latin American;Learning;Length;Life;Link;Maternal Health;maternal morbidity;Maternal Mortality;Measures;Mediating;Medical;Methods;Modeling;Morbidity - disease rate;Mothers;Myography;Myometrial;myometrium;novel;obstetrical complication;Outcome;Oxytocin;Oxytocin Receptor;Participant;Pattern;personalized decision;personalized intervention;Persons;Pharmaceutical Preparations;pharmacologic;phenome;Phenotype;Populations at Risk;Postpartum Hemorrhage;Postpartum Period;predictive tools;Pregnancy;prevent;Procedures;prospective;Prospective Studies;Publishing;pyrosequencing;racial disparity;racial population;receptor;receptor expression;Receptor Gene;Recording of previous events;Recurrence;Research;response;Risk;risk prediction;Role;Saliva;saliva sample;Sampling;Science;Shapes;Site;Social Environment;social health determinants;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Surveys;Testing;therapy design;Tissues;United States;uterine contractility;Uterine Contraction;Uterine hemorrhage;Uterine Inertia;Uterus;Variant;Western Blotting;women of color;Work

PROJECT_TITLE: Oxytocin sensitivity and postpartum hemorrhage: testing genetic and epigenetic biomarkers for improving maternal morbidity


NIH_SPENDING_CATS: Contraception/Reproduction;Maternal Health;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: GALVESTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE Sodium hydrogen exchange regulating factor-1 (NHERF-1) expression enhances during fetal membrane inflammation. Since NHERF-1 interacts with P-gp transporter protein, its molecular pathway needs to be elucidated. Along with that, the paracrine signaling of the extracellular vesicles in drug transportation at FMi will be studied.

PI_NAMEs: KAMMALA, ANANTH KUMAR  (contact)

PROJECT_TERMS: ABCG2 gene;adverse pregnancy outcome;Binding;Binding Proteins;Biological Assay;Bispecific Antibody 2B1;Carrier Proteins;Categories;Cell surface;Cells;Chorion;cigarette smoke;Clinical;Compensation;Complement;cytotrophoblast;Data;Decidua;Decidua Basalis;decidua parietalis;Decidual Cell;Devices;Disease;DLG4 gene;Down-Regulation;Drug Delivery Systems;Drug Design;Drug Efflux;Drug Kinetics;drug mechanism;Drug Regulations;Drug resistance;Drug Transport;Dyes;Environment;Evaluation;Exposure to;extracellular vesicles;Family;fetal;Fetal Membranes;Fetus;fetus cell;Gene Silencing;Glycoproteins;Human;Hydrogen;Image;improved;in utero;in vitro Model;in vivo Model;Individual;Inflammation;Inflammatory;Inflammatory Response;inhibitor;innovation;insight;Intervention;Kinetics;knock-down;Knockout Mice;Knowledge;Label;lipophilicity;Lipopolysaccharides;live cell imaging;Maternal-Fetal Exchange;microphysiology system;Microscopy;Modeling;Molecular;Mothers;Mus;myometrium;neonatal outcome;novel;Nutrient;OATP Transporters;Organ;Organ Model;organ on a chip;Oxidative Stress;Paracrine Communication;particle;Pathologic;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Pharmacotherapy;Placenta;placental membrane;placental trophoblasts;Pregnancy;Pregnancy Outcome;pregnant;protein function;Proteins;Regulation;response;Risk;Risk Factors;Role;Signal Induction;Small Interfering RNA;Sodium;sodium-hydrogen exchanger regulatory factor;solute;Stains;Tacrolimus;Technology;Teratogens;Testing;Time;Tissues;transcriptome;Transportation;trophoblast;uptake;Western Blotting

PROJECT_TITLE: Investigating the molecular mechanism of P-gp/NHERF-1 network at feto maternal interface and role of paracrine signaling of EVs containing drug transporter proteins


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: PROJECT NARRATIVE Our recently completed CRISPR screening campaign has revealed the poorly studied phosphatase SCP4 and the kinases STK35/PDIK1L as catalytic vulnerabilities in acute myeloid leukemia (AML). This multi-PI project will take an inter-disciplinary approach to elucidating the upstream and downstream mechanisms and deep biochemical and structural mechanisms of this novel signal transduction pathway that functions as an acquired dependency in AML. Since AML cells are addicted to the catalytic function of this phosphatase-kinase complex, the outcome of this work carries a strong potential to drive the development of novel tool compounds and therapeutics for a malignancy with significant unmet clinical need.

PI_NAMEs: VAKOC, CHRISTOPHER  (contact);ZHANG, YAN JESSIE

PROGRAM_OFFICER_NAME: SAYYED, ZULEKHA I

PROJECT_TERMS: Active Sites;Acute;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Allosteric Site;Binding;Biochemical;Biological Assay;Biological Markers;Biological Models;biomarker identification;Bone Marrow Transplantation;Bypass;cancer genetics;CD34 gene;Cell Nucleus;Cells;chemical genetics;chemotherapy;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Companions;Complex;Coupled;CRISPR screen;Data;Dependence;Development;Disease;DNA-Binding Proteins;Drug Targeting;Elements;Enzymes;epigenomics;Epistatic Gene;Evaluation;experience;experimental study;gene complementation;Gene Expression;Generations;Genetic;genetic approach;Genetic Epistasis;Genetic Screening;Genetic Transcription;genome editing;genome-wide;Goals;Hematopoietic;Hematopoietic stem cells;Human;Immunodeficient Mouse;Impairment;In Vitro;in vivo;inhibitor;innovation;insight;interdisciplinary approach;Investigation;Knock-out;Knowledge;Literature;Maintenance;Malignant Neoplasms;Maps;Mediating;metabolomics;Methods;Mutagenesis;Myeloid Progenitor Cells;new therapeutic target;novel;novel therapeutics;Nuclear;Oncology;Outcome;Output;paralogous gene;Pathway interactions;patient population;Patients;pharmacologic;Phenotype;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Principal Investigator;Program Sustainability;Proliferating;Protein Dephosphorylation;Protein phosphatase;Proteins;Publications;Publishing;rational design;Regulation;Research;Research Personnel;Resources;Sampling;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Site;small molecule inhibitor;structural biology;Structure;Substrate Specificity;Surface;Therapeutic;tool;tool development;transcription factor;transcriptomics;Transplantation;vector;Work;X-Ray Crystallography

PROJECT_TITLE: Elucidating the SCP4 pathway as a multi-catalytic signaling dependency in acute myeloid leukemia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-C(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative NFIA is a critical transcription factor for glial development, astrocyte-neuron network, and astrocyte activation after brain injury. The proposed research will define whether and how the manipulation of astrocytic NFIA is critical for the initiation and progression of Alzheimer's disease through delineating functional relationships between astrocytic genes, cellular signaling, transcriptome analysis, and behaviors of the newly generated AD models. Furthermore, these studies will enhance our knowledge of astrocytic and/or reactive astrocytic mechanisms that may be dysregulated in AD pathogenesis.

PI_NAMEs: CHOI, DONGJOO  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Acceleration;Adult;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Animal Model;Astrocytes;Behavior;Behavioral;Behavioral Assay;Bioinformatics;Biology;Brain;Brain Injuries;Brain region;Calcium;Calcium Signaling;candidate validation;career development;ChIP-seq;clinical investigation;college;Coupled;Data;Development;Disease;Disease Progression;Electrophysiology (science);experimental study;gain of function;gene network;Genes;Genetic;genetic manipulation;Genetic Transcription;glial cell development;Glial Fibrillary Acidic Protein;Goals;Health;Hippocampus;Human;Ion Channel;Journals;Knowledge;Learning;Link;loss of function;Mediating;Medicine;Memory;Mentors;Methods;Molecular;Multiple Sclerosis;Mus;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;Neurons;neurotransmission;Neurotransmitters;NFIA gene;novel strategies;overexpression;Pathogenesis;Pathologic;Pathway interactions;Pattern;Phagocytosis;Phenotype;Physiological;Physiology;Play;preservation;Production;Property;Publishing;Regulation;Research;response;Role;Sampling;Series;Signal Transduction;Testing;Time;tool;Training;transcription factor;transcriptome;transcriptome sequencing;Up-Regulation;Viral

PROJECT_TITLE: Investigating the role of astrocyte specific NFIA during initiation and progression of AD pathogenesis

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Narrative The brain is a complex organ composed of numerous neurons and non-neuronal cells. With age, oligodendrocytes increasingly produce a mysterious cytokine, interleukin 33 (IL-33), a potent immune regulator in peripheral systems. We will study the role of oligodendrocyte-derived IL-33 in brain aging and Alzheimer's disease-related neuroinflammation with genetically engineered mice.

PI_NAMEs: KANG, SHIN H (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: 1 year old;Abeta clearance;abeta deposition;Ablation;Acute;Affinity Chromatography;Age;Age Months;age related changes;age related decline;age related neurodegeneration;aged;Aging;aging brain;aging process;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;amyloid pathology;APP-PS1;Astrocytes;Axon;beta amyloid pathology;Biological Response Modifiers;Brain;brain shape;Cell Communication;cell type;Cells;Central Nervous System;central nervous system injury;Cognitive;Cognitive deficits;Communication;Complex;conditional knockout;coping;coping mechanism;cytokine;Demyelinations;Deposition;Development;Disease;disease phenotype;Disease Progression;Emotional;experimental study;extracellular;Family;Family member;Functional disorder;gain of function;Genetic;genetic manipulation;Genetic Variation;Genetically Engineered Mouse;Injury;injury and repair;Interleukin-1;Interleukins;Knockout Mice;Knowledge;Maintenance;Mediating;member;Metabolic;Microglia;Molecular;Morphology;Motor;mouse genetics;mouse model;Mus;mutant;Myelin;Myelin Sheath;Natural regeneration;Natural Source;Nature;neural circuit;neural repair;Neuroglia;Neuroimmune;Neuroimmunomodulation;neuroinflammation;Neurons;normal aging;novel;Nuclear;Nutritional Support;Oligodendroglia;Organ;overexpression;Patients;Peripheral;Play;Population;Production;programs;receptor;Recovery;Regulation;repaired;Resolution;response;Ribosomes;Risk;Role;Senile Plaques;Sensory;Serum;single-cell RNA sequencing;Source;Stress;synaptic pruning;System;targeted treatment;Therapeutic;Time;tool;transcriptome;transcriptome sequencing;transcriptomics;Translating;white matter

PROJECT_TITLE: Role of oligodendrocyte-derived IL-33 in brain aging and Alzheimer's disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Clinical Research;Genetics;HIV/AIDS;Immunotherapy;Infectious Diseases

PHR: PROJECT NARRATIVE The primary goals of this proposal are to identify and cultivate diverse, highly motivated, young investigators with a propensity for independent thinking, and increase their involvement in collaborative, patient-oriented HIV pathogenesis and cure research. Specifically, junior investigators will be directed engaged in multidisciplinary research including nuclear imaging strategies, HIV biomarker discovery, and tissue-based analysis of viral-host response in unique populations to foster their academic careers.

PI_NAMEs: HENRICH, TIMOTHY JENSEN (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Address;Aftercare;Anatomy;Autopsy;Award;biomarker discovery;Body Burden;career;CD4 Positive T Lymphocytes;cell motility;Cell surface;Cell Therapy;Cells;chimeric antigen receptor T cells;Clinical;Clinical Research;clinical translation;cohort;collaboratory;Combination immunotherapy;curative treatments;Custom;Data;design;Development;digital;Discipline of Nuclear Medicine;Disease remission;DNA;Drug Kinetics;Environment;Exhibits;experience;first-in-human;Fostering;Funding;Gene Modified;Genetic;Genetic Transcription;Genomic approach;Genomics;Goals;Grant;HIV;HIV envelope protein;HIV Infections;Human;Image;imaging modality;imaging study;Immune;Immune response;Immunofluorescence Immunologic;Immunohistochemistry;Immunology;ImmunoPET;Immunotherapeutic agent;Immunotherapy;improved;In Situ;In Situ Hybridization;in vivo;Individual;Infection;Infection Control;Inflammation;innate immune pathways;innovation;insight;Interdisciplinary Study;Intervention;Intervention Studies;Kinetics;Knowledge;latent HIV reservoir;Life Cycle Stages;Location;Lymph Node Tissue;lymph nodes;Lymphoid Tissue;Magnetic Resonance Imaging;Measures;Mentors;Mentorship;Methods;Microdialysis;Mid-Career Clinical Scientist Award (K24);minimally invasive;Modeling;Monitor;multidisciplinary;nano-string;new technology;novel;nuclear imaging;Outcome;Participant;participant enrollment;Pathogenesis;patient oriented;patient oriented research;Persons;Pharmaceutical Preparations;Pharmacology;Pilot Projects;Play;Population;Positron-Emission Tomography;Principal Investigator;programs;Proliferating;Proteomics;Publications;purge;Regional Anatomy;Research;Research Personnel;Residual state;response;RNA;Role;Sampling;Scientist;Site;Sudden Death;T-Cell Activation;T-Lymphocyte;Techniques;Technology;Therapeutic;Therapeutic Intervention;Thinking;Time;Tissues;TNFRSF8 gene;tool;Tracer;trafficking;Training;Transcript;transcriptomics;Tumor Markers;Viral;viral genomics;Viral Physiology;viral rebound;Virus

PROJECT_TITLE: Mentoring Scientists for Careers in HIV Translational Clinical Research

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Biomedical Imaging;Clinical Research;Pediatric;Precision Medicine;Rheumatoid Arthritis

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE There are many challenges when determining the presence and severity of joint inflammation by physical examination in children with Juvenile Arthritis. This research will 1) determine if a novel 10-joint musculoskeletal ultrasound score effectively assesses joint inflammation at the bedside, and 2) investigate the relationship of the 10-joint musculoskeletal ultrasound score with serum and synovial biomarkers. It is anticipated that accurate detection of joint inflammation may support safer and more appropriate choices for the treatment of arthritis, which in turn will improve the outcomes and quality of life of children with Juvenile Arthritis.

PI_NAMEs: VEGA FERNANDEZ, PATRICIA  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Address;adverse event risk;Affect;Age;aged;Alpha Interleukin 2 Receptor;Angiopoietin-2;Angiopoietins;Arthralgia;Arthritis;Articular Range of Motion;autoimmune rheumatologic disease;Award;Biological;Biological Assay;Biological Markers;Biology;Biopsy;candidate marker;career;career development;Career Mobility;Caring;Child;Childhood;Chronic;Chronic Childhood Arthritis;Classification;Clinical;Clinical assessments;Clinical Markers;Clinical Research;clinically relevant;clinically significant;Data;Detection;Development;Development Plans;Diagnosis;Diagnostic Imaging;Disease;Doctor of Philosophy;Enrollment;Environment;Evaluation;experience;experimental study;follow-up;Foundations;functional disability;Functional disorder;Funding;Goals;Healthcare Systems;Histologic;Image;imaging biomarker;Imaging Device;Immunology;improved;improved outcome;Inflammation;Inflammatory;innovation;instrument;Interferon Type II;Interleukin 2 Receptor;Interleukin-6;joint inflammation;joint injury;Joint Laxity;Joints;Knowledge;Longitudinal Studies;Measurement;Measures;Medical center;Mentors;Mentorship;Motion;musculoskeletal ultrasound;novel;novel strategies;Outcome;Pain;Palpation;Patients;Pediatric Hospitals;Pediatrics;Performance;personalized medicine;Pharmaceutical Preparations;Physical Examination;Pilot Projects;Plasma;point of care;professor;Protocols documentation;Provider;Publishing;Quality of life;Reference Standards;Reporting;Research;Research Activity;Research Personnel;Resources;response;Rheumatism;Rheumatoid Arthritis;rheumatologist;Rheumatology;Sampling;Scientist;Serum;Severities;Skeleton;skills;Standardization;Swelling;Symptoms;Synovial Fluid;Synovitis;System;Testing;Time;Tissues;TNF gene;Training;Training Activity;treatment choice;treatment response;Ultrasonography;ultrasound;United States National Institutes of Health;Universities;Validation;Vascular Endothelial Growth Factors;Visit

PROJECT_TITLE: Validation of a Novel Ultrasound Score to Improve the Assessment of Joint Inflammation in Children with Juvenile Arthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Infectious Diseases;Mental Health;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Teenage Pregnancy;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: BLOOMINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The proposed study seeks to design and field Wave 8 of the National Survey of Sexual Health and Behavior (NSSHB), a U.S. nationally representative probability study of individuals ages 14 and over, at a similar time frame as the United Kingdom, France, and Australia in order to facilitate cross-national comparisons. The NSSHB provides population data on sexual health indicators and has consistently tracked sexual, contraceptive, and reproductive behaviors for nearly a decade; new in Wave 8 are opportunities to establish population-representative data on understudied sexual behaviors as well as associations between those behaviors and sexual and reproductive coercion. NSSHB data have implications for informing health policies, education, and sexual health-related services.

PI_NAMEs: FU, TSUNG-CHIEH (JANE) ;HERBENICK, DEBRA LYNNE (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent and Young Adult;Adolescent Risk Behavior;Adult;Adult women;Age;aged;Anal Sex;Anxiety;Attitude;Australia;avoid pregnancy;Behavior;Behavior assessment;Choking;Coercion;Communities;condoms;Contraception Behavior;Contraceptive methods;Contraceptive Usage;cost;Country;Data;data access;Data Collection;data sharing;design;Development;Discrimination;Disease;Distress;Education;Elderly;Emotional;evidence base;experience;Family;France;Growth;Hand;Health;Health behavior;health data;health organization;Health Policy;Health Surveys;HIV;Human;human old age (65+);Individual;infection rate;Intervention;intimate partner violence;Knowledge;knowledge translation;Lesbian Gay Bisexual;Maintenance;Masturbation;Measures;meetings;member;men;Mental Depression;Mental Health;National Longitudinal Survey of Adolescent to Adult Health;neglect;Newborn Infant;non-heterosexual;Oral Sex;Pain;Participant;participant retention;Patients;Peer Review;Personal Satisfaction;Persons;physical state;pleasure;Population;population based;Post-Traumatic Stress Disorders;Pregnancy;Prevalence;prevent;Prevention;Probability;Probability Samples;Productivity;Provider;Psyche structure;Public Health;Publications;recruit;Reproductive Behavior;reproductive coercion;Research;reversible contraceptive;Risk;Sampling;satisfaction;Scientist;Services;sex;Sex Behavior;Sex Functioning;sexual and reproductive health;sexual assault;sexual coercion;Sexual Dysfunction;Sexual Health;sexual identity;sexual minority women;sexual trauma;Sexuality;sexually active;Sexually Transmitted Diseases;Social Well-Being;Surveys;symposium;System;Technology;Time;Toy;unintended pregnancy;United Kingdom;Update;Vagina;vaginal dryness;Violence;Woman;Work;World Health Organization;ZIKA

PROJECT_TITLE: Sexual Health and Behavior in a U.S. Probability Sample of Adolescents and Adults

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Pancreatic cancer is one of the most lethal cancers with a dismal five-year survival rate. Unfortunately, metastasis is frequent, thereby contributing to the poor prognosis. Calcium signaling is important in the pathogenesis of pancreatic cancer, thereby providing opportunities for new approaches to therapy.

PI_NAMEs: PITARRESI, JASON R. (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: 3-Dimensional;Accounting;Advisory Committees;Antibodies;Attenuated;Automobile Driving;Award;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;Calcium Signaling;calcium uniporter;calcium-dependent protein kinase;Cancer Etiology;career;career development;catenin p120ctn protein;Cause of Death;cell motility;Cell Proliferation;Cells;Cessation of life;Clinical;Clinical Management;Code;cohort;Cytoplasm;detection method;Development Plans;Disease;Disease Management;Early Diagnosis;efficacy evaluation;efficacy testing;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Esophagus;Event;experimental study;Faculty;Family;Foundations;Funding;Gene Expression Profiling;Genes;Genetic;Genetically Engineered Mouse;Goals;Grant;Health;hormone therapy;Human;Immune;Immune Evasion;Immunotherapeutic agent;Immunotherapy;improved;KPC model;KRASG12D;Ligands;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;member;Mentors;Mitochondria;mouse model;Mus;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;Neoplastic Cell Transformation;neutralizing antibody;neutralizing monoclonal antibodies;novel;novel strategies;novel therapeutics;Null Lymphocytes;Oncogenes;Oncogenic;Organoids;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic tumorigenesis;parathyroid hormone-related protein;Pathogenesis;Pathway interactions;Patients;Phase;Phenotype;Play;preclinical trial;Primary Neoplasm;Process;Prognosis;Proteins;recruit;Research;research and development;Role;Signal Pathway;Signal Transduction;skills;Solid;Squamous cell carcinoma;Stains;Survival Rate;System;Testing;Therapeutically Targetable;Training;Transplantation;tumor;tumor growth;Tumor Suppressor Genes;tumor-immune system interactions;Tumor-infiltrating immune cells;United States National Institutes of Health;Work

PROJECT_TITLE: Dissecting the oncogenic and pro-metastatic roles of PTHLH-mediated calcium signaling in pancreatic cancer

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE There is no known treatment to heal the human spinal cord once it is damaged; however, recent reports show electrical stimulation at specific locations near the surface of the spinal cord restores functions such as standing and stepping in humans with paralysis from spinal cord injury. Insufficient scientific evidence is available to explain how spinal stimulation interacts with the spinal cord to recover functions, and although the outcomes are promising, prior studies were conducted in a very small number of humans with wide-ranging degrees of paralysis. In order to better understand how spinal stimulation produces functional gains, we will conduct a mechanistic exploratory clinical trial in 32 humans with spinal cord injury that is designed to examine how electrical stimulation affects the signals that enter and exit the spinal cord during spinal stimulation with intense rehabilitation.

PI_NAMEs: GRAHN, PETER JONAS (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: 3-Dimensional;Address;Affect;Algorithms;Animals;Bilateral;Biomechanics;Brain;Characteristics;Chronic;clinical trial participant;Clinical Trials;Computer Analysis;Computer Models;computer studies;Data;design;Dorsal;dorsal column;Dura Mater;effective therapy;Electric Stimulation;Electrodes;Electromyography;Electrophysiology (science);Failure;FDA approved;Frequencies;functional gain;functional restoration;healing;Human;Implant;implantation;improved;Injury;Ipsilateral;Knowledge;Location;loss of function;man;Motion;Motor;Motor Activity;motor function recovery;Motor output;motor recovery;motor rehabilitation;Neural Pathways;neuromuscular;neuromuscular activity;Nociception;Outcome;Output;Pain;Pain management;painful neuropathy;Paralysed;Paraplegia;Participant;Pathologic;Performance;Peripheral Nervous System;pharmacologic;Physiologic pulse;Physiological;Physiology;Property;Proprioception;Protocols documentation;Reaction;Recovery;Recovery of Function;Rehabilitation therapy;Reporting;Research;response;Role;Sensory;Severities;Signal Transduction;Site;Skin;Spinal;Spinal Cord;Spinal Cord Column;Spinal cord injury;spinal nerve posterior root;spinal reflex;Stimulus;Structure;success;Supination;Surface;System;Task Performances;Testing;Thoracic spinal cord structure;tool;translational potential;transmission process;Trauma;United States Food and Drug Administration;Walking;Weight-Bearing state;Width;Work

PROJECT_TITLE: Elucidating spinal sensorimotor network components that underlie recovery of motor functions via lumbosacral epidural electrical stimulation in humans with spinal cord injury

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative Cigarette smoking remains one of the leading preventable causes of death and disease in the world. The goal of the proposed project is to develop a better understanding of the psychological and neurobiological factors that contribute to smoking lapses during cessation attempts. Results from the project will provide a foundation for future research aimed at improving the effectiveness of strategies for preventing smoking lapses.

PI_NAMEs: WILSON, STEPHEN JEFFREY (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Abstinence;Acute;Adult;Affect;base;Behavior;Behavioral;Brain;Cause of Death;Cigarette;cigarette smoking;cingulate cortex;clinically relevant;Cognition;cognitive process;Complex;Coupling;craving;design;Disease;Effectiveness;executive function;Failure;Female;Foundations;Functional Magnetic Resonance Imaging;Goals;Hour;improved;indexing;innovation;insight;Knowledge;Lateral;Lead;Link;male;Measures;Medial;Mental Processes;Methodology;Methods;Modeling;negative affect;Negative Reinforcements;neural;Neurobiology;Nicotine;novel;Outcome;Parietal Lobe;Patient Self-Report;Pattern;Prefrontal Cortex;prevent;Prevention strategy;Process;Protocols documentation;psychologic;Psychological reinforcement;Relapse;Research;response;Risk;Scanning;segregation;Self-control as a personality trait;sex;Smoke;Smoking;Smoking Behavior;smoking cessation;smoking initiation;smoking relapse prevention;Testing;Theoretical model;Thinking;Time;trait;Work

PROJECT_TITLE: Linking brain network dynamics to imminent smoking lapse risk and behavior

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Neurosciences

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Neurons are poorly recognized by the immune system which contributes to the ability of neurotropic pathogens to persist in the CNS. However, there is evidence that T cells can promote clearance of these organisms from neurons, but the basis for this activity is not well understood. The parasite Toxoplasma gondii, has a latent cyst forms that survives in neurons which helps it evade immune surveillance and ensures chronicity. There is a dire need for new therapies for this latent stage. To understand how T. gondii is recognized in neurons and how the parasite can evade surveillance, novel reporter systems for parasites will be used to track the fate of infected neurons in vivo and studies performed to determine if cyst specific responses can help eradicate this pathogen. These studies will have a significant impact on understanding how CD8+ T cell-neuron interactions lead to pathogen control and be relevant to other neurotropic infections.

PI_NAMEs: HUNTER, CHRISTOPHER A (contact);KOSHY, ANITA

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Affect;Antigens;antimicrobial;candidate identification;CD8-Positive T-Lymphocytes;Cell Communication;Cells;Cellular Stress;Central Nervous System;Chronic;Cyst;cytokine;Data;Data Set;Dissection;effector T cell;Ensure;Enterobacteria phage P1 Cre recombinase;exhaust;Gene Expression Profiling;Goals;Hematopoietic;imaging study;Immune Evasion;Immune system;Immunologic Surveillance;Immunologic Tests;Immunologics;In Vitro;in vivo;in vivo imaging;Infection;infection management;Interferon Type II;Interferons;intravital imaging;Lasers;Lead;Lytic;Maps;Mediating;MHC Class I Genes;Microglia;Modeling;mouse model;multiphoton imaging;neuroinflammation;Neurons;neurotropic;novel;novel therapeutics;Organism;Parasite Control;Parasites;pathogen;Pathway interactions;Phenotype;Population;Process;Production;Reporter;Reporter Genes;Resistance;response;STAT1 gene;System;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Time;Toxoplasma;Toxoplasma gondii;transcription factor;Transgenic Organisms;Visualization

PROJECT_TITLE: Neuronal Latency and Toxoplasma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)M]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hypertension;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Telehealth

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Hypertension (HTN) is especially morbid for patients living in underserved urban communities, who experience healthcare-related disparities. The proposed research is relevant to public health by improving HTN treatment and self-management in urban individuals with this common, chronic condition. This proposal expects to empower individuals residing in communities with socioeconomic disadvantage and will provide critical data to develop an acceptable technological tool for HTN self-management.

PI_NAMEs: JOHNSON, AMBER ELAINE (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Adult;Affect;Area;Award;behavior change;Behavior Therapy;Behavioral;Cardiac health;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;career;career development;Caring;Censuses;Chronic;Chronic Disease;Clinical;Clinical Trials;cohort;Communities;community engagement;community setting;comparison group;Consensus;Data;deprivation;design;Development;Disadvantaged;Disease Management;Disparity;Economically Deprived Population;Educational process of instructing;empowerment;Ensure;Essential Hypertension;evidence base;experience;Funding;Future;Geography;global health;Goals;Grant;Guidelines;Health;health equity;Health Services Accessibility;Health Services Research;Health Technology;Healthcare;Healthcare Systems;high risk;Home Blood Pressure Monitoring;human centered design;Hypertension;hypertension control;hypertension treatment;improved;indexing;Individual;Inequality;Infrastructure;innovation;Intervention;intervention program;Interview;Investigation;Knowledge;Leadership;life span;Life Style Modification;Location;Measures;Mentors;Mentorship;Methodology;Methods;mHealth;mhealth interventions;mHealth self-management;Modeling;mortality;National Heart, Lung, and Blood Institute;neighborhood disadvantage;Neighborhoods;Outcome;Participant;Patient Care;Patient Education;patient oriented;patient oriented research;Patients;Persons;Physicians;Pilot Projects;pilot test;poor health outcome;Population Heterogeneity;Populations at Risk;Process;Professional Organizations;programs;Public Health;Qualitative Methods;Randomized;Research;research and development;Research Personnel;Resources;Risk;Risk Factors;risk mitigation;satisfaction;Science;Scientific Advances and Accomplishments;Scientist;Self Management;skills;social;Social Conditions;social determinants;Social isolation;socioeconomic adversity;socioeconomic disadvantage;socioeconomics;Strategic vision;System;Technology;Testing;theories;therapy development;tool;Training;treatment adherence;underserved community;Update;Urban Community;Urban Population;urban underserved;usability;Writing

PROJECT_TITLE: Mobile Health for Enhanced Hypertension Self-Management in Underserved Urban Residents

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]