FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Pediatric;Prevention;Suicide;Suicide Prevention

ORG_CITY: EUGENE

ORG_NAME: KSANA HEALTH, INC.

PHR: PROJECT NARRATIVE  Despite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death amongst youth. Digital tools, especially personal smartphones, are promising avenues to address these issues and can be used to increase engagement with effective interventions such as suicide safety planning. This Fast-Track SBIR proposal will enhance the effectiveness of the delivery of BRITE, a suicide safety planning smartphone application for youth at risk for suicide, by developing and testing an augmented version of the app that will integrate just-in-time adaptive intervention features to enhance engagement with the plan and thereby increase its effectiveness.

PI_NAMEs: ALLEN, NICHOLAS B (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: adaptive intervention;Address;Adolescent;automated algorithm;Benchmarking;brief intervention;care providers;Cause of Death;Cellular Phone;Collaborations;commercialization;Coping Skills;Development;digital mental health;digital tool;Dissemination and Implementation;Distress;Dose;Ecological momentary assessment;effective intervention;Effectiveness;effectiveness clinical trial;effectiveness evaluation;emotional distress;Evaluation;evidence base;Evidence based intervention;Face;Feeling suicidal;Future;Health;high risk;improved;Individual;Intervention;meetings;Methods;mobile sensing;Monitor;Notification;Parents;patient engagement;Patients;Phase;Pragmatic clinical trial;product development;protective factors;Randomized;randomized trial;Recommendation;reducing suicide;Research;Research Personnel;Resources;response;Risk;Safety;Self Efficacy;Small Business Innovation Research Grant;smartphone application;Software Engineering;success;Suggestion;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Testing;Time;treatment optimization;Universities;usability;web site;Youth

PROJECT_TITLE: BRITE 2.0: A just-in-time adaptive intervention for suicide safety planning in adolescents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-C (10)]


ADMINISTERING_IC: HG

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: INTERNATIONAL MAMMALIAN GENOME SOCIETY

ORG_STATE: NC

PHR: The International Mammalian Genome Conferences provide an essential annual venue that brings together mammalian and biomedical geneticists from across the world to interact, form new collaborations and plan new research programs with the goal of improving the use of mammalian models to improve the health and well-being of people. An important aspect of the conferences is the training and mentoring of young scientists. The first site of this proposal is in Washington, DC by joining with the Genetics Society of America at the pan-organismal Allied Genetics Conference (TAGC) that is held every 4 years for the third time.

PI_NAMEs: BEIER, DAVID R. (contact)

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Ally;Area;Asia;Biological Models;career;career development;Collaborations;Communities;Department chair;Educational workshop;Environment;Europe;Fostering;functional genomics;Funding;Genetic;genetic analysis;Genetic Research;genome annotation;Goals;harassment;Health;Human Biology;human disease;Human Genetics;improved;Individual;Infrastructure;Institution;International;Journals;Laboratory mice;Leadership;Mammalian Genetics;mammalian genome;meetings;member;Mentors;Mentorship;Methodology;Modeling;Mutagenesis;Personal Satisfaction;Persons;Phenotype;Policies;Positioning Attribute;Postdoctoral Fellow;Pre-Clinical Model;Professional Organizations;professor;programs;Reproducibility;Research;Research Personnel;Resources;Rotation;Running;Scholarship;Science;Scientist;Secure;Site;Societies;student conference;Students;symposium;Technology;Time;Training;trait;Translating;United States National Institutes of Health;Washington;Work

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science

ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: MAPS 2024 PROJECT NARATIVE The C. elegans Metabolism, Aging, Pathogenesis, Stress and Small RNAs symposium (MAPS) is a biennial international gathering that brings together researchers using C. elegans to study aging and the related disciplines of stress, metabolism, pathogenesis and small RNAs. C. elegans is a major platform for aging research and many foundational discoveries and mechanistic insights have originated through worm studies. Major goals of the 2024 MAPS meeting are (i) to provide a platform for presentation of predominantly unpublished, cutting-edge discoveries in worm aging from both established and new investigators, (ii) to provide opportunities for postdoc and graduate-student trainees, especially women and under-represented minorities (URMs) to present their research in oral talks and posters, (iii) facilitate mentoring and networking platforms for new faculty and trainees, particularly women and URMs, and (iv) to bring completely new ideas to aging research.

PI_NAMEs: DOUGLAS, PETER MAHAN (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Aging;aging mechanism;aging process;aging related;Area;Biological Models;Biology of Aging;Caenorhabditis elegans;care systems;career;Child Care;Collaborations;Communities;Data;Disabled Persons;Discipline;doctoral student;Educational workshop;Ethnic Origin;Event;Faculty;Family;Feedback;Female;Funding;Geroscience;Goals;graduate student;Grant;hallmarks of aging;high reward;high risk;improved;Individual;innovation;insight;interdisciplinary approach;interdisciplinary collaboration;interest;International;Knowledge;Learning;Lightning;meetings;member;Mentors;Metabolism;Mission;model organism;novel;Oral;Participant;Pathogenesis;Physiological;Postdoctoral Fellow;posters;Process;programs;Research;Research Personnel;Role;Science;Scientist;Seasons;senior faculty;Senior Scientist;Site;Small RNA;Stress;symposium;Thinking;Underrepresented Minority;Underrepresented Populations;Universities;Wisconsin;Woman

PROJECT_TITLE: C. elegans Metabolism, Aging, Pathogenesis, Stress and Small RNAs Symposium

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Complementary and Integrative Health;Neurosciences;Pain Research

ORG_CITY: SILVERTHORNE

ORG_NAME: KEYSTONE SYMPOSIA

ORG_STATE: CO

PHR: PROJECT NARRATIVE Mammalian somatosensation is essential to our everyday life and experiences, such as being able to walk in a straight line or learning to play the piano. Since we rely on our sensations of itch, touch, and pain for emotional well-being and a range of behaviors, somatosensory dysfunction results in numerous clinical conditions that impact millions of people worldwide. This Keystone Symposia conference was designed to highlight major areas of somatosensation, progressing from the molecular level to the dynamics of neural circuits, behavior, and disease, to encourage the sharing of cutting-edge, unpublished data, to facilitate dynamic discussion and debate, as well as to promote new collaborations in the field.

PI_NAMEs: SHEPPARD, TERRY L. (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Academia;Address;Area;Basic Science;Behavior;Behavioral;Biology;career;chronic pain management;Clinical;clinical practice;clinically relevant;Collaborations;Data;design;Disease;disease model;Educational Background;Educational workshop;Environment;equity, diversity, and inclusion;Ethnic Origin;experience;Faculty;Functional disorder;Future;Gender;Goals;Government;Health;high reward;Human;human disease;improved;Industry;Interdisciplinary Study;interest;Interoception;Knowledge;Learning;Life;Mammals;Methodology;model organism;Modeling;Molecular;Molecular Genetics;neural;neural circuit;Neurons;Neurosciences;New Mexico;next generation;novel;novel strategies;Outcome;Pain;Pathway interactions;Persistent pain;Persons;Play;posters;Process;programs;Pruritus;Race;receptor;recruit;Religion;Research;Research Personnel;Scientist;seal;Sensory;Signal Transduction;socioeconomics;somatosensory;Somatosensory Disorders;symposium;Technology;Time;tool;Touch sensation;Walking;Well in self;Work

PROJECT_TITLE: Mammalian Somatosensation: Mechanisms of Itch, Touch, Pain and Interoreception in Health and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-P (11)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: PROJECT NARRATIVE Hematopoiesis is the process by which the cellular components of the blood cells are formed, and research into these pathways has enhanced our understanding of other areas, including stem cell biology, aging, inflammation and blood cancer. Recent advances have changed the way that hematological malignancies can be targeted in the clinic using small molecule drugs, antibodies and cell-based therapies. This Keystone Symposia conference will provide a platform for basic and clinical investigators from across disciplines and around the globe to establish productive collaborations and stimulate new ideas to accelerate progress in hematology field and bring new medicines to the clinic.

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acceleration;Address;Aging;Antibodies;Area;Biological;Biology;Blood;Blood Cells;Bone Marrow;cancer diagnosis;career development;Cell Fate Control;Cell Therapy;Cells;cellular engineering;Clinic;Clinical;clinical application;Clinical Investigator;clinical practice;Collaborations;Colorado;Communities;Copper;Development;Diagnosis;Discipline;Disease;Educational workshop;Electronic Medical Records and Genomics Network;Emerging Technologies;epigenome;Event;Future;Genome engineering;Goals;Hematologic Neoplasms;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic stem cells;Homeostasis;imaging approach;Immune;improved;Individual;Industrialization;Inflammation;Inflammatory;insight;interest;International;Knowledge;Laboratories;Learning;leukemic transformation;Medicine;member;Methodology;Methods;Modeling;Molecular;multidisciplinary;multiple omics;next generation sequencing;novel strategies;Outcome;Pathway interactions;Pharmaceutical Preparations;posters;Process;Productivity;Research;Research Personnel;Role;Scientist;small molecule;small molecule therapeutics;sound;stem cell biology;Stress;symposium;Technology;Testing;Therapeutic;transcriptome;Untranslated RNA;Work

PROJECT_TITLE: Hematopoiesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-G (O3)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE The US now requires e-cigarette warnings. We propose to evaluate these warnings and new ones to study their intended and unintended consequences, especially for dual users.

PI_NAMEs: BREWER, NOEL TODD (contact)

PROGRAM_OFFICER_NAME: KIMMEL, HEATHER L

PROJECT_TERMS: Address;Adolescent;Adult;Advertising;Affect;Age;arm;Attention;authority;Behavior;Cancer Etiology;cancer prevention;Cigarette;combustible cigarette;Communication;Data;Development;Devices;Disease;e-cigarette cessation;Electronic cigarette;electronic cigarette use;electronic cigarette user;Evaluation;evidence base;experimental study;follow-up;Frequencies;Goals;hazard;Hazard Identification;Image;innovation;Label;Lesbian Gay Bisexual;Low income;Modeling;Motivation;negative affect;Nicotine Dependence;Outcome;Participant;Persons;pilot test;Policies;Predisposition;Probability Samples;Protocols documentation;Randomized;Research;response;risk perception;Smoke;Smoker;Smoking;Smoking Behavior;smoking cessation;smoking initiation;Social Interaction;Subgroup;Surveys;Text;Thinking;Time;Tobacco;tobacco products;Tobacco use;vaping;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Informing ENDS policies:  Studying the impact of e-cigarette warnings on behavior


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW ORLEANS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Chagas disease, caused by the parasitic protozoa Trypanosoma cruzi, represents a major public health problem in the Americas. We will develop more reliable tools for the diagnostic and genotyping of T. cruzi from blood samples of congenital and maternal cases. This would be fundamental to better understand T. cruzi molecular and clinical epidemiology, including the links between parasite diversity and congenital infection, leading to a better health care for Chagas disease patients and particularly infected pregnant women.

PI_NAMEs: HERRERA, CLAUDIA P (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: accurate diagnostics;Americas;antibody detection;Antigenic Diversity;Antigens;Argentina;Bioinformatics;Blood specimen;Bolivia;Chagas Disease;Characteristics;Chronic;Clinical;clinical epidemiology;comparative genomics;congenital infection;Coupled;Detection;Development;Diagnosis;Diagnostic;Diagnostic tests;diagnostic tool;Disease;DNA Markers;Enzyme-Linked Immunosorbent Assay;Evaluation;Evolution;Genetic Variation;Genome;Genotype;Healthcare;Honduras;improved;Infant;Infection;innovation;Latin America;Link;Marker Discovery;Mexico;Molecular;Molecular Epidemiology;molecular marker;neglect;Newborn Infant;next generation;next generation sequencing;novel;novel diagnostics;parasite genome;Parasites;Patients;Peptides;Plasma;Pregnant Women;Prospective Studies;Protozoa;Public Health;rapid test;Recommendation;Reporting;Research;Role;Sampling;Scheme;screening;Sensitivity and Specificity;Serodiagnoses;Serology test;Serum;Site;Specificity;Symptoms;Techniques;Testing;tool;transmission process;Trypanosoma cruzi;United States;Validity and Reliability;vector

PROJECT_TITLE: Development of Improved Serological Diagnostic and Parasite Genotyping Tools for Congenital Chagas Disease

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;HIV/AIDS;Human Genome;Immunization;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The correct topological organization and transcriptional regulation of the B-lymphocyte genome during development and antibody gene diversification processes prevents aberrant chromosomal translocations and promotes appropriate diversification mechanisms. Recent advances in transcriptomics and genomics have identified the role of the noncoding RNA processing complex RNA exosome in the organization of the B cell genome and regulation of the DNA mutator protein Activation Induced Deaminase (AID). In this application, we evaluate the role of the RNA exosome complex, its cofactor proteins, the non-coding RNAs it processes including CTCF-binding element RNAs, and the roles of the 3D genomic architecture of the chromatin in regulating AID activity leading to robust class switch recombination and somatic hypermutation at the immunoglobulin loci genes.

PI_NAMEs: BASU, UTTIYA  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: 3-Dimensional;activation-induced cytidine deaminase;Address;Affinity;Alleles;Antibodies;Antibody Affinity;Antigens;Architecture;B-Lymphocytes;Binding;Biochemical;Biological Assay;Catalysis;Cell Line;Cell Separation;Chromatin;chromatin remodeling;Chromosomal translocation;cofactor;cohesin;Complex;Cytidine;Data;Deamination;Development;Disease;DNA;DNA Polymerase II;DNA Sequence;DNA Structure;Double-Stranded RNA;Elements;Enhancers;Etiology;Exons;Exonuclease;exosome;Family;Generations;Genes;Genetic;Genetic Transcription;Genome;genome editing;Genomic Instability;genomic locus;Genomics;Germ Lines;Grant;Heavy-Chain Immunoglobulins;humoral immunity deficiency;Hybrids;Hyper IgM syndrome type 2;IGH@ gene cluster;Immunity;Immunoglobulin Class Switching;Immunoglobulin Genes;Immunoglobulin Somatic Hypermutation;immunoglobulin structure;Immunoglobulin Switch Recombination;Immunoglobulins;Immunologic Deficiency Syndromes;interest;Kinetics;Laboratories;large cell Diffuse non-Hodgkin's lymphoma;Life;Light-Chain Immunoglobulins;Lymphomagenesis;Macromolecular Complexes;Maintenance;Mediating;Molecular;mouse model;Multiple Myeloma;Mus;Mutagenesis;Mutate;Mutation;Neurodegenerative Disorders;novel;Oncogenic;Outcome;Play;prevent;Prevention;Process;promoter;Property;protein activation;Proteins;recruit;Regulation;Research Design;RNA;RNA Binding;RNA Degradation;RNA Helicase;RNA Polymerase II;RNA Processing;Role;Single-Stranded DNA;Site;Structure of germinal center of lymph node;Technology;therapy development;Transcript;transcription termination;Transcriptional Regulation;transcriptome;transcriptomics;tumorigenesis;Untranslated RNA;V(D)J Recombination;variable region gene;Work

PROJECT_TITLE: Role of ncRNA Surveillance Complex "RNA Exosome" in Class Switch Recombination and Somatic Hypermutation


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Immunization;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases;Transplantation;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Narrative Cancer immunotherapy has been demonstrated to provide remarkable clinical benefit, and a contributor to this benefit is thought to be the high number of cancer mutations, present in some cancers, which can produce surface molecules called mutated peptides that can stimulate tumor-specific immune responses. However, for many cancers like chronic lymphocytic leukemia (CLL), the number of cancer mutations that are detected through standard methods is low, but a growing body of evidence suggest that these types of blood cancers have many alternative types of molecular changes that can still generate targets recognizable by the immune system. We propose to build an integrated program using innovative genomic technologies and mass spectrometry to better detect these new classes of patient-specific mutated peptides, to develop predictive tools for their identification, and then to apply these new tools to better understand how immune responses to these mutated peptides shape the clinical history of CLL and its response to immunotherapy exposure.

PI_NAMEs: WU, CATHERINE JU-YING (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Allogenic;analysis pipeline;Antigen Targeting;antigen-specific T cells;Antigens;Autologous;Binding;Biological Assay;Biotechnology;Blood;Cancer Burden;cancer genome;cancer immunotherapy;candidate validation;chimeric antigen receptor T cells;Chronic Lymphocytic Leukemia;chronic lymphocytic leukemia cell;Clinical;cohort;computer infrastructure;Data;Data Set;Detection;Disease;Elements;Epitopes;Evaluation;Event;experience;Feedback;Generations;Genomics;Glioblastoma;graft vs leukemia effect;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Human;immune checkpoint blockade;Immune response;Immune system;Immunity;immunogenic;immunogenicity;Immunotherapy;improved;inhibitor;innovation;leukemia;Ligands;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Melanoma;Memory;Methods;methylome;MHC Interaction;Molecular;Mutate;Mutation;Mutation Detection;Myeloid Cells;Natural History;neoantigen vaccination;neoantigens;neoplastic cell;next generation sequencing;nonsynonymous mutation;novel;novel sequencing technology;novel therapeutics;Output;Patients;Peptide Library;Peptide/MHC Complex;Peptides;predictive modeling;predictive tools;Principal Investigator;programs;Progress Reports;prospective;Protein Isoforms;Recording of previous events;Reporting;response;Ribosomes;RNA Splicing;Role;Sampling;Shapes;Single Nucleotide Polymorphism;Site;Source;Surface;T cell response;Technology;The Cancer Genome Atlas;Time;tool;Training;Transcript;transcriptome;transcriptome sequencing;Translating;treatment response;tumor;Tumor Antigens;Vaccination;Vaccinee;Vaccines;Validation;Variant;Viral Antigens;Writing

PROJECT_TITLE: Personal tumor neoantigens for immunity against chronic lymphocytic leukemia

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The neurotransmitter dopamine critically controls physiological functions such as movement, learning, cognition and reward by activating receptors expressed on downstream neurons. Dopamine receptors are found along the cell surface and also within the primary cilium, a specialized cellular compartment whose influence on neuronal function is not well-understood. The current proposal will (a) investigate how dopamine receptors are translocated to primary cilia in cell models, (b) test whether these mechanisms are conserved in neurons, and (c) examine the impact of dopamine receptor signaling from primary cilia on neuronal activity.

PI_NAMEs: FAGAN, RITA REALE (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Address;Binding;Binding Proteins;Biochemical;Biological Assay;Biosensor;Brain;career;Cell Culture Techniques;Cell Line;Cell membrane;Cell model;Cell surface;Cells;Cilia;ciliopathy;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;Cognition;Complex;Corpus striatum structure;CRISPR/Cas technology;Cultured Cells;Cyclic AMP;Defect;Development;Dopamine;Dopamine Receptor;Exclusion;experimental study;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gene-editing approach;Genetic Diseases;Goals;Institution;Learning;Mediating;Mediator;Modeling;Molecular;monoamine;Morphology;Movement;Mus;Neurologic Symptoms;Neuromodulator;Neurons;neuroregulation;Neurotransmitters;novel;Pathway interactions;Physiological;Population;protein transport;Proteins;Proteomics;prototype;Publishing;Rattus;receptor;Receptor Activation;Receptor Signaling;Regulation;Reporting;Rewards;Scientist;Sensory;Signal Pathway;Signal Transduction;Slice;structural determinants;Structural Protein;Surface;Techniques;Testing;Time;tool;trafficking;Training;Transfection;Validation;Work

PROJECT_TITLE: Investigating the trafficking mechanisms and signaling consequences of dopamine receptor primary cilia localization


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Project Narrative We have developed inhibitors of a cancer-promoting protein called spliced X box-binding protein-1 (XBP-1s) and shown that these inhibitors are effective in killing chronic lymphocytic leukemia (CLL). In addition, we have shown that activation of a protein called the stimulator of interferon genes (STING) can also cause CLL cell death. Because both inhibition of XBP-1s and activation of STING can suppress a critical survival mechanism called B cell receptor signaling, we propose to treat CLL through a combination of these approaches and believe that results emanating from this study will inform new treatment strategies to combat CLL.

PI_NAMEs: DEL VALLE, JUAN R;HU, CHIH-CHI ANDREW (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Adult;Age;Agonist;anti-tumor immune response;Antibodies;Apoptosis;B-Cell Antigen Receptor;B-Cell Lymphomas;B-Lymphocytes;Binding Proteins;biological adaptation to stress;Biology;cancer cell;cancer therapy;cancer type;Cell Death;Cell surface;Cell Survival;cell type;Cells;Chronic;Chronic Lymphocytic Leukemia;chronic lymphocytic leukemia cell;Clinic;Clinical Trials;combat;combinatorial;Cytoplasm;Data;Deceleration;Development;Diagnosis;Disease;DNA;drug resistance development;Drug Targeting;endoplasmic reticulum stress;Engineering;Exhibits;FDA approved;Foundations;Gene Activation;Genes;Growth;Head and Neck Neoplasms;Hematopoietic Neoplasms;Human;Human body;humoral immunity deficiency;Immune system;Immunity;Immunologic Stimulation;In Vitro;in vivo;indexing;Indolent;Induction of Apoptosis;Infection;inhibitor;Integral Membrane Protein;Interferon Type I;kinase inhibitor;large cell Diffuse non-Hodgkin's lymphoma;leukemia;Ligation;Link;Lymphoma;Malignant Neoplasms;Mediating;Methods;Modeling;Monitor;mouse model;MS4A1 gene;Multiple Myeloma;Mus;Mutate;Names;nanobodies;novel;novel therapeutic intervention;older adult;Pathway interactions;Patients;PD-1 blockade;pembrolizumab;Pharmaceutical Preparations;Phase I Clinical Trials;Production;Proteins;Receptor Signaling;Research;Research Project Grants;Research Project Summaries;Resistance;RNA Splicing;Solid Neoplasm;sortase;Stimulator of Interferon Genes;Stimulus;synergism;Testing;Therapeutic;Toxic effect;Tumor Burden

PROJECT_TITLE: XBP1 Inhibition and STING activation for the treatment of cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-L(02)M]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative: Development of effective vaccines is the time-tested approach for controlling infectious diseases in humans and animals. The proposed work has the potential to discover adjuvants that stimulate potent immunity to influenza virus and fungal vaccines. The findings from the proposed work are expected to have broad implications in the development of vaccines against diverse microbial pathogens of humans.

PI_NAMEs: KLEIN, BRUCE STEVEN;SURESH, MARULASIDDAPPA  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Adjuvant;Agonist;Agreement;Animals;anti-fungal agents;Antigens;Binding;Blastomyces;C Type Lectin Receptors;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;Collaborations;Combined Vaccines;Communicable Diseases;Cytoprotection;dectin 1;design;Development;Dinucleoside Phosphates;factor C;Fostering;functional plasticity;fungal pneumonia;Fungal Vaccines;fungus;Genetic Transcription;Glucans;Goals;Human;human pathogen;Immunity;Immunization;Immunologic Receptors;Immunologist;Infection;Influenza A virus;influenza A virus nucleoprotein;influenzavirus;Inhalation;innovation;insight;Interleukin-2;Licensing;Ligands;Lipid A;Lung;Maintenance;Memory;memory CD4 T lymphocyte;mouse dectin-2;Mucous Membrane;Mycoses;nanoemulsion;parenteral administration;particle;pathogen;pathogenic fungus;pathogenic microbe;pathogenic virus;Pathway interactions;Periodicity;Polysaccharides;PPBP gene;Primary Infection;Productivity;programs;Public Health;Reporting;Residencies;respiratory;Respiratory System;Respiratory Tract Infections;single-cell RNA sequencing;sound;stem cells;stemness;Structure of parenchyma of lung;System;T cell response;T memory cell;T-Lymphocyte;Testing;Th1 Cells;Time;Tissues;TLR4 gene;tool;transcription factor;transcriptome;Vaccine Adjuvant;vaccine development;vaccine formulation;Vaccines;Viral;Viral Respiratory Tract Infection;Virus;Work

PROJECT_TITLE: Combination Adjuvants to Program Durable Immunity to Respiratory Viral and Fungal Pathogens


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Acute Kidney Injury (AKI) is common in hospitalized patients and dramatically increases morbidity and mortality, however, it is frequently overlooked and untreated. Because of the heterogenous nature of AKI, personalized recommendations tailored to individual patients and delivered directly to the patient care team may improve AKI outcomes. This proposal aims to 1) determine whether a rapid response style Kidney Action Team can improve clinical outcomes of patients with AKI, 2) which patients and providers benefit from this intervention and 3) whether an automated system can accurately mimic the recommendations made by human Kidney Action Teams.

PI_NAMEs: WILSON, FRANCIS PERRY (contact)

PROGRAM_OFFICER_NAME: JALAL, HAMID

PROJECT_TITLE: Personalized Recommendations for Acute Kidney Injury (AKI) Care Using a Kidney Action Team: A Randomized Trial

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Health Services;Hematology;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Patient Safety;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Anemia, defined by low hemoglobin content in the blood, is common in pregnancy, impairing the health of the mother as well as babies. Although the condition can easily be treated with currently available supplements or infusions, anemia is detected too late or not at all. This research focuses on developing a mobile health technology to simply measure blood hemoglobin levels using digital photos of the eyelid, maximizing the currently available resources for anemia diagnosis and management during pregnancy, in particular in the developing world and resource-limited (or at-home) settings.

PI_NAMEs: KIM, YOUNG L (contact);WERE, MARTIN CHIENG

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Affect;African;Algorithms;Anemia;automated algorithm;Biological;biomedical informatics;Blood;Cellular Phone;Clinical;Clinical Data;clinical practice;Color;Complex;Computational algorithm;cost;Data;data acquisition;deep learning;design;Devices;Diagnosis;Diagnostic;digital;digital health;Disease;Electronic Health Record;electronic health record system;Environment;Equipment;Eyelid structure;Fetal health;Foundations;Goals;health of the mother;Health Services Accessibility;Health Technology;Hemoglobin;Hemoglobin concentration result;Home;Hyperbilirubinemia;Iatrogenesis;Image;Impaired health;implementation science;improved;Infusion procedures;innovation;Kenya;Laboratories;Learning;learning algorithm;Light;low and middle-income countries;Machine Learning;machine vision;Malaria;Manuals;Maternal Health;Measures;Methodology;Methods;mHealth;mobile application;Mobile Health Application;Modeling;Morbidity - disease rate;mortality;next generation;Optics;Outcome;Oxygen;Pain;Patient Care;patient screening;Performance;Perfusion;Peripheral;Persons;point of care;Population;Pregnancy;Pregnant Women;Process;Public Health;Pulse Oximetry;reconstruction;Recovery;remote patient monitoring;Research;Resource-limited setting;Resources;Rural;sensor;Sickle Cell Anemia;signal processing;Site;Spectrum Analysis;Structure of palpebral conjunctiva;Technology;Telemedicine;Testing;Tissues;Translational Research;Work

PROJECT_TITLE: Maternal mHealth blood hemoglobin analysis with informed deep learning

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: ATLANTA

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Spatial neglect is a common symptom after stroke and negatively impacts the ability to achieve independent functional mobility post stroke. This NRSA F31 proposal aims to explore and generate new information regarding the combination of novel motor and spatial training approaches (prism adaptation therapy + electrical stimulation and prism adaptation therapy + gait training) to enhance the rehabilitation of spatial neglect and walking function in individuals post-stroke. This work will generate novel information that will inform future design of new and targeted treatment protocols for evidence-based rehabilitation of spatial neglect and gait dysfunctions post- stroke, to improve gait function and quality of life in stroke survivors.

PI_NAMEs: ALOBA, OLUFISAYO O (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Affect;Attention;Attentional deficit;Behavior;behavior measurement;Biomechanics;clinical training;cognitive function;combinatorial;Combined Modality Therapy;common symptom;Data;design;Detection;Diagnosis;disability;effective therapy;Electric Stimulation;Electric Stimulation Therapy;Electrodes;evidence base;Evidence based treatment;Failure;fall risk;Functional disorder;Future;Gait;Gait abnormality;gait rehabilitation;Goals;Hypokinesia;improved;inattention;Individual;Knowledge;Left;Length of Stay;Long term disability;Lower Extremity;Measures;Mentors;Motor;Motor disability;motor learning;Movement;National Research Service Awards;neglect;neuroimaging marker;Neurologist;neuromuscular stimulation;novel;Output;Paresis;Pathologic;Performance;Persons;Physical Rehabilitation;physical therapist;post stroke;Production;Protocols documentation;Quality of life;Recovery;Rehabilitation Outcome;rehabilitation paradigm;Rehabilitation therapy;Research Personnel;Research Proposals;Sampling;Scientist;Side;simulation;Spatial Behavior;spatial neglect;Stimulus;Stroke;stroke rehabilitation;stroke survivor;Surface;System;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Training;Treatment Protocols;treatment response;Upper Extremity;Walking;Weight-Bearing state;Work

PROJECT_TITLE: Novel spatial-motor approaches targeting post-stroke spatial neglect and gait deficits


ORG_NAME: NEW YORK GENOME CENTER

PHR: Project Narrative Understanding how the molecular components, inherited lineage, and spatial milieu of single cells dictate function in health and disease remains a key outstanding challenge in genomics. The overarching goal of our Center for Integrated Cellular Analysis is to develop methods to simultaneously assess these multimodal cellular properties, develop tools to harmonize them to allow inferential assessment of cell identity based on partial phenotyping, and share these developments with the broad scientific community while encouraging community engagement through education and outreach. Success in our strategy will facilitate deep, multi-omic phenotyping of single cells for basic research and clinical applications.

PI_NAMEs: LANDAU, DAN ;SATIJA, RAHUL  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Academic Training;Address;analytical method;Anatomy;Atlases;Awareness;Basic Science;Biological;Biological Assay;biological systems;cell behavior;Cell Communication;Cell Lineage;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromatin;clinical application;combinatorial;Communities;community engagement;Complex;Computer software;Computing Methodologies;Copy Number Polymorphism;cost;Data;data integration;Data Set;deep learning;Development;Disease;DNA Methylation;Education;Education and Outreach;Environmental Risk Factor;epigenome;Epitopes;experimental study;extracellular;Genes;Genetic Polymorphism;Genome;Genomics;Goals;Health;Heritability;Human body;Immunofluorescence Immunologic;In Situ;indexing;Individual;Inherited;innovation;insight;Joints;Learning;Measurement;Measures;Membrane Proteins;Messenger RNA;Methods;Mission;Modality;Molecular;multimodality;multiple omics;New York City;novel strategies;Output;outreach;Phenotype;Play;Population;Positioning Attribute;Process;Property;Proteins;Proteome;Protocols documentation;reconstruction;Recording of previous events;Resolution;Resource Sharing;Role;Series;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Source;success;Systems Biology;Taxonomy;Technology;Time;tool;transcriptome;transcriptome sequencing;transcriptomics;Underrepresented Students;Variant;whole genome

PROJECT_TITLE: Center for Integrated Cellular Analysis


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Tendons can withstand large forces due to a highly aligned, dense collagen matrix. Though a minor component of tendon, type III collagen contributes to properties of the extracellular matrix and cellular activity. This study will define the contribution of type III collagen to neonatal tendon development and the enhanced healing capacity of the neonatal tendon, revealing potential targets for improving mature tendon healing and informing clinical approaches to conditions with reduced type III collagen including vascular Ehlers Danlos Syndrome, aging, menopause, and smoking.

PI_NAMEs: TAMBURRO, MARGARET KATHRYN (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Acceleration;Adult;Aging;Biology;Blood Vessels;Cells;Cellular Infiltration;Cellularity;Characteristics;Cicatrix;Clinical;clinically relevant;Collagen;Collagen Fiber;Collagen Fibril;Collagen Type I;Collagen Type III;comparative;crosslink;defined contribution;density;Deposition;Development;Developmental Process;Diameter;Dryness;Economic Burden;Ehlers-Danlos Syndrome;Environment;Extracellular Matrix;fetal;fibrillogenesis;Fibroblasts;Foundations;Gene Expression;Glean;Growth;healing;Immunohistochemistry;improved;Incidence;Infiltration;inflammatory milieu;injured;Injury;innovation;insight;Integrins;Investigation;joint mobilization;knock-down;Knock-out;Laboratory Research;Measures;mechanical properties;Mechanics;Menopause;migration;Minor;Modeling;mouse model;multidisciplinary;Mus;Natural regeneration;Neonatal;neonatal mice;neonate;novel;Orthopedics;Pennsylvania;Perinatal;Phase;Play;postnatal;postnatal development;Predisposition;prenatal;Process;progenitor;Property;Proteomics;recruit;regenerative;regenerative approach;Regulation;Reproducibility;Research Personnel;Resistance;response;response to injury;Role;Scientific Inquiry;Smoking;stem cell differentiation;stem cell migration;stem cells;Stress;tendon development;Tendon Injuries;Tendon structure;Testing;therapeutic target;Time;Tissue Engineering;Tissues;Training;Transmission Electron Microscopy;Universities;viscoelasticity;Weight;Work;wound healing

PROJECT_TITLE: Defining the Role of Type III Collagen in Neonatal Tendon Development and Healing


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Sleep Research

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE)    Sleep disturbances  predict  increased  risk  of  Alzheimer’s  disease  (AD).  Deficits  in  sleep  impair  memory  consolidation  and  contribute  to  the  accumulation  of  Aβ,  the  neurotoxic  peptide  that  builds  up  in  the  brains of AD  patients, thereby  affecting daily  function and  critically  contributing  to  disease  progression.  Our goal is to determine whether restoring activity in the thalamic reticular nucleus can normalize sleep,  reduce Aβ accumulation, and improve memory.

PI_NAMEs: BEIERLEIN, MICHAEL ;CHIN, JEANNIE  (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: abeta accumulation;Abeta clearance;abeta deposition;Abeta synthesis;Acute;Address;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Animal Model;Attention;Behavior;Brain;Brain region;Cell Nucleus;Cells;Chronic;Cognition;Cognitive;Cognitive deficits;Complex;daily functioning;Deposition;design;designer receptors exclusively activated by designer drugs;Disease;Disease Progression;Disinhibition;Electrophysiology (science);Exhibits;Functional disorder;Goals;Hippocampus;Human Amyloid Precursor Protein;Impairment;improved;improvement on sleep;in vivo;insight;Intercellular Fluid;interstitial;Lead;Maintenance;Mediating;Memory;memory consolidation;Memory impairment;Microdialysis;mouse model;Mus;mutant;neuron loss;Neurons;neurotoxic;novel;novel therapeutic intervention;Pathology;Peptides;Pharmacology;Phase;poor sleep;Property;Proteins;public health relevance;restoration;risk prediction;Seizures;Sleep;Sleep Architecture;Sleep Deprivation;Sleep disturbances;Sleep Fragmentations;Sleep Wake Cycle;Slice;Slow-Wave Sleep;Synapses;targeted treatment;tau Proteins;Testing;Thalamic structure;Therapeutic;Transgenic Mice;Viral;Wakefulness

PROJECT_TITLE: Thalamic Reticular Nucleus Dysfunction in Alzheimer's Disease


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Rare Diseases

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: In addition to the increasingly well understood repertoire of mutations in coding sequences of oncogenes and tumor suppressor genes, genome-wide sequencing of human cancers has revealed abundant mutations in non-coding sequences. Most of these mutations are expected to be neutral, i.e., passengers, with only a small percentage having a functional impact, so identifying bona fide oncogenic mutations within this large background of neutral ones is an important challenge. In this project we seek to address this challenge in a common and difficult to treat human cancer, multiple myeloma, using a mechanism-based genetic-epigenetic mapping strategy, followed by functional assays on the resulting candidate oncogenic non-coding mutations.

PI_NAMEs: TYCKO, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: 3-Dimensional;Address;Alleles;Apoptosis;Area;B-Lymphocytes;Binding Sites;Bioinformatics;bioinformatics pipeline;Biological;Biological Assay;bisulfite sequencing;Bone Marrow;cancer subtypes;candidate identification;Cell Line;Cell Proliferation;Cells;Chromatin;Chromatin Structure;Chromosome Mapping;Clinical;clinically relevant;Code;CRISPR/Cas technology;Data;Disease Progression;DNA Methylation;DNA methylation profiling;Elements;Enhancers;Epigenetic Process;Gene Expression;Genes;Genetic;Genetic Enhancer Element;genome sequencing;genome-wide;Goals;Hematologic Neoplasms;Human;in vivo;Insulator Elements;lymphoblastoid cell line;Malignant Neoplasms;Maps;Methods;Methylation;methylation pattern;mimetics;molecular subtypes;mRNA Expression;Multiple Myeloma;Mutagenesis;mutant;Mutation;neoplastic cell;Oncogenes;Oncogenic;Pathway interactions;Patients;peripheral blood;Pharmaceutical Preparations;Point Mutation;Procedures;Prognosis;promoter;Recurrence;Regulatory Element;Research;Resistance;Sampling;Series;Signal Transduction;Site;Somatic Mutation;System;targeted sequencing;Testing;three dimensional cell culture;transcription factor;treatment response;Triage;Tumor Bank;Tumor Suppressor Genes;Untranslated RNA;whole genome;Xenograft procedure

PROJECT_TITLE: Identifying and characterizing functional noncoding mutations in multiple myeloma

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ORG_CITY: CHICAGO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Asthma and allergic diseases are among the most common chronic diseases in children and adults, yet therapeutic advances have been incremental. We propose here a highly integrated program to discover and define functions for causal variants and causal genes associated with asthma and allergic diseases, with a focus on variants and genes that impart risk through their effects on lung-resident cells and are promising therapeutic targets.

PI_NAMEs: NOBREGA, MARCELO A.;OBER, CAROLE  (contact);SPERLING, ANNE I.

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Address;Adult;Affect;Allergic Disease;Allergic rhinitis;Asthma;Bacterial Artificial Chromosomes;biobank;Biological;Biology;Birth;bronchial epithelium;candidate identification;Categories;causal variant;Cell Physiology;cell type;Cells;Child;Chronic Disease;Clinical;clinical heterogeneity;clinical phenotype;cohort;cost;Data;data management;Development;Diagnosis;Disease;disease heterogeneity;disorder risk;disorder subtype;Engineering;Enhancers;Environment;Environmental Exposure;Epithelial Cells;Epithelium;ethnic diversity;Ethnic Population;Food Hypersensitivity;gene discovery;gene function;Genes;Genetic;Genetic Risk;genome wide association study;genome-wide;Genomics;Goals;Health Care Costs;Healthcare Systems;Heritability;Human;Hypersensitivity;Immune;Immunologics;Immunology;Individual;Infrastructure;Knowledge;Link;Lung;Lymphocyte;Maps;Molecular;mouse model;multi-ethnic;Myeloid Cells;new therapeutic target;novel;Outcome;Pathogenesis;Peripheral;personalized medicine;Phenotype;precision medicine;Process;programs;Quantitative Trait Loci;Reporting;Research Personnel;Resources;respiratory smooth muscle;Rest;Risk;risk variant;Role;Services;skin hypersensitivity;Smooth Muscle;Specificity;Technology;Testing;Therapeutic;therapeutic target;Tissues;tool;trait;transcriptome sequencing;Translations;Variant;Work

PROJECT_TITLE: Integrated genetic, omic, and immunologic studies to identify endotypes and novel drug targets for asthma and allergic diseases


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Asthma;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention

ORG_CITY: BERKELEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Asthma is the most common chronic illness of childhood, and low lung function in childhood is associated with worse lung health throughout adult life. This project will identify the harmful and protective effects of early pregnancy and early childhood exposure to a mixture of metals on children’s sensitivity to allergens, risk of asthma, and lung function. The results from this research will advance our understanding of the role of early life metal exposure in shaping children’s respiratory health through effects on immune function, informing future public health actions to improve respiratory health.

PI_NAMEs: THILAKARATNE, RUWAN  (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Address;Adult;Affect;Air;airborne allergen;Allergens;Allergic;American;Animals;Area;Asthma;Biological Markers;Birth;Blood;California;career development;Child;Child Health;Childhood;Childhood Asthma;Chronic Disease;Chronic Obstructive Pulmonary Disease;cohort;Collaborations;Competence;Complement;cost;Data;Development;Developmental Process;Diagnosis;Diet;dietary;early childhood;early life exposure;early pregnancy;Educational workshop;Ensure;Environment;Environmental Epidemiology;Environmental Health;epidemiology study;epigenome;Erythrocytes;Evaluation;exposed human population;Exposure to;Extrinsic asthma;Faculty;Fellowship;First Pregnancy Trimester;Forced expiratory volume function;Future;Growth;Health;Health Expenditures;Housing;Hypersensitivity;IgE;Immediate hypersensitivity;Immune;immune function;Immune system;improved;in utero;Individual;innovation;insight;Intervention;Investments;Joints;Knowledge;Lead;Life;Life Cycle Stages;Link;Lung;lung development;lung health;Massachusetts;Measures;Mediating;Mediation;meetings;Mentors;Metal exposure;Metals;Methods;Morbidity - disease rate;Mothers;neurodevelopment;novel;Outcome;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;Perinatal Epidemiology;Perinatal Exposure;postnatal;prenatal;prenatal exposure;Prevention strategy;Productivity;protective effect;Public Health;public health priorities;pulmonary function;Pulmonary Pathology;Recommendation;recruit;Research;Research Personnel;Resources;respiratory health;respiratory morbidity;Risk;Role;Scientist;Serum;Shapes;Source;Spirometry;Statistical Computing;symposium;Systems Development;Time;Toxicology;Training;Universities;Water;Work;Writing;Zinc

PROJECT_TITLE: Early life exposure to metal mixtures: impacts on asthma and lungdevelopment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Neurosciences;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Stroke;Traumatic Head and Spine Injury

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE After common neurological injuries like stroke, spinal cord injury, and traumatic brain injury, restoring walking ability and functional independence are some of the most important and challenging goals of physical rehabilitation. A drawback of many gait retraining approaches is that patients can quickly accommodate to physical assistance, causing them to lose sensorimotor engagement, which in turn impedes neuroplasticity and progress towards functional goals. The proposed work aims to enhance engagement and motor learning during gait retraining by harnessing positive social pressures; this will make physically assisted rehabilitation more effective, and in the long term, improve quality of life after neurological injury by stabilizing fall risks and reducing comorbid conditions and medical costs.

PI_NAMEs: MANCZUROWSKY, JULIA ROSE (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: acute stroke;Address;Affect;Architecture;barrier to testing;Biological Models;Caregivers;Caring;Cognitive;cognitive neuroscience;cognitive task;comorbidity;comparison control;Economic Burden;Effectiveness;Engineering;environmental enrichment for laboratory animals;Equilibrium;Exercise;fall risk;Feedback;Fellowship;functional independence;functional restoration;Gait;Gait abnormality;gait rehabilitation;Goals;habituation;hamstring;Impaired cognition;Impairment;improved;Individual;innovation;Interdisciplinary Study;Intervention;kinematics;Learning;learning outcome;Leg;Length;Locomotion;Mechanics;Mediating;Medical Care Costs;member;Mentorship;Motivation;Motor;motor learning;motor recovery;Movement;Nervous System Trauma;Neurologic;neuromuscular;Neuronal Plasticity;Neurosciences;Outcome;Participant;Patients;Perception;Performance;Physical Rehabilitation;physical therapist;Population;post stroke;pressure;Process;programs;Psychological reinforcement;Quality of life;rate of change;Rehabilitation Outcome;Rehabilitation therapy;rehabilitative care;Rewards;robotic system;Role;Savings;Science;Scientist;Sensory;social;Social Psychology;socioeconomics;Spinal cord injury;Standardization;stroke-like episode;success;System;Telerobotics;theories;Time;Training;Translating;Traumatic Brain Injury;treadmill;Walking;Work

PROJECT_TITLE: Harnessing the Kohler Effect to Promote Motor Learning During Physically Assisted Rehabilitation


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases;Sexually Transmitted Infections;Wound Healing and Care

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative HSV-1 causes eye disease and can lead to blindness. Our data indicate that HSV-1 glycoprotein K (gK) binds to signal peptide peptidase (SPP) and UL20, while UL20 binds to Golgi-specific DHHC zinc finger protein (GODZ). The absence of SPP or GODZ affect HSV-1 infectivity in vitro and in vivo. We will use several approaches to determine if blocking these interactions reduces virus replication in the eye as well as latency- reactivation hence, the occurrence of reactivation and eye disease. Our studies are expected to provide a novel therapeutic strategy to control vision loss from HSV-1 infection.

PI_NAMEs: GHIASI, HOMAYON  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Affect;Amino Acids;Antigen Receptors;Area;Attenuated;Binding;Binding Proteins;Binding Sites;Blindness;Cell surface;Cells;Clinical;clinically significant;conditional knockout;Cornea;Corneal Diseases;corneal scar;Cytoplasm;Data;Dermatitis;Developed Countries;Development;Disease;Dominant-Negative Mutation;effector T cell;Embryo;Endoplasmic Reticulum;Eye;Eye diseases;Eye Infections;Face;FDA approved;Funding;Genes;Glycoproteins;Goals;Golgi Apparatus;Herpes stromal keratitis;Herpesvirus 1;Immune response;Immunize;immunoregulation;In Vitro;in vivo;Infection;innovation;insight;Knock-out;Knockout Mice;latent infection;Maps;Mediating;Modeling;Mouse Strains;Mus;mutant;Neurons;novel;novel strategies;novel therapeutic intervention;palmitoylation;Pathogenicity;Peptides;Peripheral Nerves;Persons;Pharmaceutical Preparations;Play;prevent;Prevention strategy;Primary Infection;Proteins;Publishing;reactivation from latency;recombinant virus;Recombinants;Recurrence;response;Role;signal peptide peptidase;Simplexvirus;small hairpin RNA;Specificity;Structure of trigeminal ganglion;Tamoxifen;targeted treatment;Testing;therapeutic target;therapeutically effective;trafficking;Virus;Virus Replication;Zinc Fingers

PROJECT_TITLE: The Role of gK in HSV-1 Induced Corneal Scarring


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PHR: Project Narrative The gastrointestinal side effects of chemotherapy are estimated to affect as high as 70% of patients receiving treatment. There are currently no available therapies to prevent these debilitating gastrointestinal side effects. The main goal of these studies is to employ translationally relevant mouse models to better understand the pathways that drive intestinal plasticity and healing to resist chemotherapy-related intestinal injury.

PI_NAMEs: DEANS-FIELDER, KALI KRISTINNA (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Affect;Attenuated;Autophagocytosis;Cancer Model;Cancer Patient;Celiac Disease;Cell Differentiation process;cell injury;Cell Proliferation;cell type;chemoradiation;chemotherapy;college;Communication;Complex;Core Facility;Critical Thinking;Crohn's disease;Data;Diarrhea;Disseminated Malignant Neoplasm;DNA Damage;Dose;Doxorubicin;effective therapy;enteric infection;epithelial injury;Epithelium;Equipment;experience;experimental study;Fasting;FDA approved;Fibroblasts;Fostering;gastrointestinal;Gene Modified;Goals;healing;Hour;In Vitro;Inflammation;Injury;injury prevention;injury recovery;insight;intestinal epithelium;intestinal injury;Intestinal Mucosa;Intestinal Neoplasms;Intestines;Measures;Mediating;Medical;Medicine;Membrane;Mentorship;Modeling;Morbidity - disease rate;mouse model;Mucositis;Mucous body substance;Mucous Membrane;Mus;Natural regeneration;novel;Pain;Paneth Cells;Pathway interactions;Patient Compliance;Patients;Pharmaceutical Preparations;Physicians;Play;Pluripotent Stem Cells;postmitotic;prevent;Prevention;Preventive therapy;Process;Prognosis;protective effect;Proteins;Publishing;reconstitution;reduce symptoms;regeneration following injury;regenerative;Research;Resistance;response;Role;Scientist;side effect;Sirolimus;stem cells;stemness;Techniques;Technology;Testing;Therapeutic;Time;Tissues;Training;treatment group;Vomiting;Work

PROJECT_TITLE: The Role of Autophagy in Intestinal Regeneration


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Maternal Health;Nutrition;Obesity;Pediatric;Physical Activity;Pregnancy;Prevention;Women's Health Research

ORG_CITY: GREENVILLE

ORG_NAME: EAST CAROLINA UNIVERSITY

PHR: Project Narrative Factors like maternal obesity and exercise during pregnancy can impact the health of offspring at birth and later in life; little is known about which types of maternal exercise is most beneficial to mother and child, when attempting to break the intergenerational cycle of obesity and metabolic disorders. This study will assess outcomes, for mothers and infants, of three different types of exercise interventions (aerobic, resistance, and combined), comparing expectant mothers with overweight/obesity to a control group. By taking key measurements throughout pregnancy and up to 12 months after delivery, this study will provide insight into the most beneficial mode of maternal exercise for the target population.

PI_NAMEs: MAY, LINDA E (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Abdomen;Adult;Aerobic;Aerobic Exercise;Age;Age Months;American College of Obstetricians and Gynecologists;antenatal;Attenuated;Biological Markers;Birth;Birth Weight;Blood Pressure;Body fat;Body mass index;C-reactive protein;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Child;Child Health;Childhood;Cholesterol;clinical practice;Conceptions;Control Groups;Data;design;Disease;effective intervention;efficacious intervention;Enrollment;Environment;Exercise;exercise intervention;exercise training;Exhibits;fetal;Gestational Diabetes;glucose metabolism;Goals;Growth;Guidelines;Habits;Health;heart function;Heart Rate;Hyperglycemia;Hyperinsulinism;Hyperlipidemia;Hypertension;improved;improved outcome;in utero;Incidence;Infant;Infant Health;infant outcome;Inflammatory;innovation;insight;insulin sensitivity;intergenerational;Life;Lipids;Longitudinal Studies;longitudinal, prospective study;Low-Density Lipoproteins;Maternal Health;maternal obesity;maternal weight;Measurement;Measures;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic syndrome;metabolomics;Methods;mode of exercise;Morbidity - disease rate;mortality;Mothers;Motor;next generation;obese mothers;Obesity;obesity in children;obesity prevention;obesity risk;offspring;Outcome;Outcome Assessment;Overweight;overweight child;Pathway interactions;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Outcome;Pregnant Women;prenatal;programs;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Research;Resistance;resistance exercise;Risk;Risk Marker;skills;Target Populations;Testing;Time;treatment as usual;United States;Weight;Weight Gain;Woman;Work

PROJECT_TITLE: Effect of exercise modality during pregnancy on childhood obesity risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-C(90)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Microneedles facilitate drug delivery by forming micropores in the skin. Variability in micropore closure times in diverse skin types may reduce efficacy of this drug delivery approach. In this project we will 1) determine the impact of micropore closure times on delivery of a model drug through the skin, and 2) explore the role of dopamine signaling in microwound closure timeframes in diverse skin types. The overall goal is to identify a possible pharmaceutical target for delaying micropore closure and improving microneedle assisted transdermal drug delivery.

PI_NAMEs: COTA, VALERIA  (contact)

PROJECT_TERMS: absorption;Acceleration;Affect;Agonist;antagonist;Area;Biochemical;Biological Assay;Bypass;Catecholamines;Cells;Clinical;clinical practice;CREB1 gene;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Development;Diffusion;Dopamine;Dopamine Agonists;Dopamine Antagonists;Dopamine D2 Receptor;Dopamine Receptor;Drug Delivery Systems;drug efficacy;Drug Kinetics;Drug Modelings;electric impedance;Epidermis;Frequencies;G-Protein-Coupled Receptors;Gel;Genetic;Goals;healing;Hepatic;Human;hydrophilicity;Impaired healing;improved;In Vitro;in vivo;Individual;insight;interest;keratinocyte;knock-down;Length;Lipids;Measurement;Measures;Mediating;Melanins;Metabolism;Methods;Metronidazole;micropore;Needles;Neurotransmitters;Optical Coherence Tomography;Painless;Pathway interactions;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phosphorylation;Physiological Processes;Plasma;Population Heterogeneity;prevent;Process;Production;Proliferating;Property;receptor binding;Receptor Signaling;Recovery;Research;Role;Signal Transduction;Skin;skin color;Skin Physiology;Skin wound healing;small hairpin RNA;Solid;Spectrum Analysis;Stimulus;Stratum corneum;Testing;Therapeutic;therapy outcome;Thick;Time;Topical application;Transdermal substance administration;translational approach;Tyrosine;Variant;Visualization;Water;Western Blotting;wound;wound healing

PROJECT_TITLE: Mechanisms of micropore closure after microneedle application in diverse skin types


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

ORG_CITY: EAST LANSING

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Narrative Lung cancer is the deadliest malignancy worldwide, and recent patient data confirm the importance of the Nrf2 pathway in this disease, as up to 30% of human lung adenocarcinomas have a mutation that activates this pathway. While Nrf2 activation in tumor cells can promote tumor cell survival, preclinical studies show anti-tumor effects with drugs that activate Nrf2. These studies will identify the immunomodulatory effects of Nrf2 activation in the microenvironment of the lung and help determine whether pharmacological Nrf2 activation could be beneficial for the treatment of lung cancer.

PI_NAMEs: MOERLAND, JESSICA ANN (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Affect;Angiogenic Factor;anti-cancer;anti-cancer research;Anti-Inflammatory Agents;anti-tumor immune response;antitumor effect;Biological Models;Bone Marrow;Cancer Biology;cancer cell;Cancer Etiology;Cancer Patient;cancer prevention;cancer therapy;career;Cell Survival;cell type;Cells;Cessation of life;Chemoresistance;Chemotactic Factors;Clinical;Clinical Trials;CRISPR/Cas technology;Cysteine;Cytoprotection;Data;Defense Mechanisms;Development;Disease;Educational process of instructing;Environment;Esters;experimental study;Flow Cytometry;Genes;genome editing;Human;Imaging Techniques;Immune;immune cell infiltrate;immunoregulation;In Vitro;in vivo;in vivo imaging;in vivo Model;ineffective therapies;Infiltration;Inflammatory;inflammatory marker;inflammatory milieu;Injections;Knock-out;knockout gene;Knockout Mice;Learning;Lung;Lung Adenocarcinoma;lung carcinogenesis;Lung Neoplasms;Macrophage;Macrophage Activation;Malignant neoplasm of lung;Malignant Neoplasms;Modeling;mouse model;Mus;Mutate;Mutation;neoplastic cell;Non-Small-Cell Lung Carcinoma;Normal Cell;novel;novel therapeutics;oleanane;Oxidative Stress;Pathway interactions;patient biomarkers;patient prognosis;patient response;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;polarized cell;Population;pre-clinical;preclinical study;protective pathway;recruit;Reporting;Research Personnel;Role;Signal Pathway;skills;success;Survival Rate;Techniques;Terpenes;Testing;therapeutic target;Training;transcriptomics;tumor;Tumor Burden;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;tumorigenic;ultrasound;United States;Wild Type Mouse

PROJECT_TITLE: The Immunomodulatory Effects of Nrf2 Activation on Macrophages in the Lung Tumor Microenvironment


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Brain Disorders;Dementia;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: The proposed research is relevant to public health because understanding the role of endolysosomal pathways in the formation of neurotoxic axonal misfolded prion protein aggregates is expected to provide a framework on which to develop novel pharmacological strategies for the treatment of prionopathies. Thus, elucidation of the composition, ultrastructure, and mechanism of formation of axonal prion protein aggregates is relevant to the part of NIH’s mission that promotes the understanding of basic cell biological principles as a basis for protecting human health.

PI_NAMEs: ENCALADA, SANDRA E (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: aggregation pathway;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;Architecture;Automobile Driving;Autopsy;Axon;Binding;Biological;Brain;Brain Pathology;Brain region;Cells;Characteristics;cofactor;Complex;Cytoskeleton;Deacetylation;Deposition;design;Development;Diagnosis;Down-Regulation;Electron Microscopy;Electrons;Elements;Endocytic Vesicle;Endosomes;Excision;Functional disorder;Generations;Genetic;Goals;Golgi Apparatus;Health;Human;Impaired Cytoskeletal Integrity;Impairment;in vivo;innovation;insight;Investigation;light microscopy;Mediating;Membrane;Microtubules;Mission;Mitochondria;Modeling;Molecular;Molecular Conformation;mouse model;Multivesicular Body;Mus;mutant;Mutation;Nerve Degeneration;Neurites;Neurodegenerative Disorders;neurofilament;Neurologic;Neurons;neurotoxic;novel;Organelles;Pathogenesis;Pathology;Pathway interactions;Patients;pharmacologic;Pharmacological Treatment;Poison;Prion Diseases;Prions;protein aggregation;Proteins;Proteomics;PrP;Public Health;Research;Rodent;Role;Route;Site;Sorting;Structure;targeted treatment;tau Proteins;Testing;therapy development;trafficking;treatment strategy;United States National Institutes of Health;Vacuole;Vesicle

PROJECT_TITLE: Mechanisms of Mutant Prion Protein Aggregation Within Endolysosomal Pathways

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: Belo Horizonte

ORG_COUNTRY: BRAZIL

ORG_FIPS: BR

ORG_NAME: FOUNDATION FOR RESEARCH DEVELOPMENT

PHR: Project Narrative Brucellosis is one of the world’s most frequent zoonotic diseases with over 500,000 new human infections every year. This proposal defines the pathways of innate immune activation or inhibition by Brucella abortus strain 19 vaccine. Identifying the mechanisms of activation or inhibition of innate immune responses used by strain 19 will determine the issues with the current vaccine and suggest changes to enhance its efficacy and disease control.

PI_NAMEs: BARBER, GLEN N.;OLIVEIRA, SERGIO C (contact);SMITH, JUDITH ANNE;SPLITTER, GARY A

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Acids;Adjuvant;Affect;Animals;Anti-Bacterial Agents;ATF6 gene;Bacterial DNA;Binding Proteins;Biological Response Modifiers;Black Box;Brazil;Brucella;Brucella abortus;Brucella abortus infection;Brucellosis;CASP1 gene;Caspase;Cattle;Cell Line;Cells;Cellular biology;Cessation of life;Chromosome 3;chronic infection;conditional knockout;Cytoplasm;Cytosol;Data;Disease;disorder control;DNA;Economic Burden;experimental study;Flow Cytometry;GBP1 gene;Genetically Engineered Mouse;glucose uptake;Goals;guanylate;Health Care Costs;Host resistance;Human;Immune;immune activation;Immune response;Immunity;in vivo;Infection;Infection Control;Inflammasome;Inflammation;inhibitor;innate immune pathways;Innate Immune Response;Interferons;Interleukin-1 beta;Interleukin-4;ITGAX gene;Knockout Mice;Ligands;Macrophage;Measures;Mediating;Metabolic;Microbiology;Mitochondria;Mus;Natural Immunity;pathogen;Pathogenesis;Pathway interactions;Phenotype;prevent;Production;Productivity;Proliferating;Property;protein expression;Proteins;Quality of life;receptor;Research;Research Personnel;Resistance;Resistance to infection;Respiration;response;Role;Secure;sensor;Small Interfering RNA;Social Impacts;Succinates;tauroursodeoxycholic acid;Testing;transcription factor;Transfection;transmission process;vaccine efficacy;vaccine-induced immunity;Vaccines;Vacuole;Zoonoses

PROJECT_TITLE: Brucella induces STING-mediated Guanylate-Binding Protein expression and Unfolded Protein Response: Balancing Bacterial Elimination, Inflammation and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: This proposed research is relevant to the mission of the NIH because uncovering the underlying mechanisms linking energy/nutritional intake and AD pathology will provide novel therapeutics to both prevent and cure neurodegenerative age-onset diseases, which represent ever growing burdens to public health.

PI_NAMEs: MAIR, WILLIAM B (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acute;Age;age effect;Age of Onset;age related changes;aged;Aging;aging process;Agonist;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapeutic;AMP-activated protein kinase kinase;Amyloid beta-Protein;Animals;Back;Biochemical Pathway;Biological;Caenorhabditis elegans;Calcium;Cell Physiology;cell type;Cells;Cellular biology;Clinical Trials Design;Communication;cytotoxic;Data;Defect;dietary restriction;Disease susceptibility;disorder risk;Environment;extend lifespan;Feedback;Functional disorder;Genetic;Genetic Transcription;Goals;hallmarks of aging;Homeostasis;in vivo;Intake;Learning;Link;Longevity;Mediating;Memory;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;metabolomics;Mission;Mitochondria;mitochondrial metabolism;Nerve Degeneration;Neurons;neuroprotection;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Nutritional;obese patients;Onset of illness;Organelles;Pathogenicity;Peptides;Peripheral;Phenformin;prevent;Process;proteostasis;Public Health;rate of aging;Regulation;Reporter;Reporting;Research;Reverse engineering;RNA;RNA Splicing;Role;Signal Transduction;Site;System;targeted treatment;Tissues;United States National Institutes of Health

PROJECT_TITLE: Reversing Loss of Metabolic Homeostasis to Ameliorate Alzheimer's Disease Pathogenicity


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because timely, effective care for respiratory failure saves lives. Hispanic patients are twice as likely as other patients to die from respiratory failure, yet the existing literature does not identify how to address this critical problem. This proposal meets an urgent need to detect, understand, and eliminate modifiable contributors to inequities in respiratory failure by ethnicity through rigorous patient and clinician cohort research and development of stakeholder-centered interventions.

PI_NAMEs: ARMSTRONG-HOUGH, MARI  (contact);VALLEY, THOMAS SEBASTIAN

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Activities of Daily Living;Address;Age;American;arm;Behavior;behavior change;Belief;bilingualism;care delivery;Caring;Cessation of life;Characteristics;Clinical;Clinical Data;clinical practice;Cognitive;cohort;Cohort Studies;Communication;Communication Barriers;Community Hospitals;comorbidity;COVID-19;Critical Care;Critical Illness;Data;Death Rate;design;Disabling;Disparity;disparity elimination;disparity reduction;Equity;Ethnic Origin;EuroQOL;experience;Family;Financial Hardship;functional outcomes;Funding;health disparity;health equity;Health Services Research;Hispanic;Hispanic Populations;Hospitalization;Hospitals;Household;improved outcome;Inequity;innovation;Intensive Care Units;Intervention;intervention refinement;Interview;Knowledge;Literature;Measures;Methods;Modeling;mortality;Motivation;Multicenter Trials;multidisciplinary;National Heart, Lung, and Blood Institute;Not Hispanic or Latino;Nurses;Observational Study;Organization administrative structures;Outcome;outcome disparities;Outcome Study;patient registry;Patients;Physical Function;Physical therapy;Physicians;Positioning Attribute;Process;prototype;Public Health;Quality of life;remediation;Reporting;Research;research and development;Research Design;Research Personnel;Resources;Respiratory Failure;respiratory health;Risk;Risk Adjustment;secondary analysis;Sedation procedure;Severity of illness;sex;Site Visit;social determinants;sociologist;Specific qualifier value;standard of care;Structure;success;Surveys;Survivors;Testing;therapy design;Work

PROJECT_TITLE: Promoting Equity via Change in Practice for Respiratory Failure (PRECIPICE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-N(02)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Sleep is a conserved and essential behavior, whose function remains unclear. Disorders of sleep are common and important causes of human morbidity. This proposal seeks to gain a deeper understanding of the regulation and function of sleep, in order to improve the treatment of dysregulated sleep and address a scientific question of paramount importance.

PI_NAMEs: WU, MARK N (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Address;Animals;Arousal;Astrocytes;Behavior;Behavioral;Cells;circadian;circadian pacemaker;circadian regulation;Code;Dedications;Disease;Drosophila genus;Electrophysiology (science);Future;Genetic study;Goals;Homeostasis;Human;human morbidity;imaging modality;improved;insight;Investigation;Mediating;Methods;Molecular;Molecular Analysis;multidisciplinary;Multimodal Imaging;Mus;Nature;neural;neural circuit;Neurobiology;Neuronal Plasticity;Neurons;neurophysiology;Neurosciences Research;novel strategies;Pathway interactions;Physiology;Process;Program Research Project Grants;Regulation;Research;Role;Sleep;sleep behavior;Sleep Disorders;Sleep disturbances;sleep regulation;Somnambulism;Study models;suprachiasmatic nucleus;Time;Work

PROJECT_TITLE: Cross-Species Analyses of the Molecular and Circuit Basis ofSleep


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Human Genome;Precision Medicine

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE Advances in genomics have exposed our inability to functionally characterize genetic variants that associate with sudden cardiac death risk, leaving excessive variants of unknown significance (VUS). We will use Deep Mutational Scanning as a mechanism to uncover all functional genetic variants in a potassium channel and link this data with TOPMed and UK BioBank databases. This is an innovative proactive, data-driven approach, that will establish actionable data usable by clinicians and research teams alike.

PI_NAMEs: ECKHARDT, LEE LOCHBAUM (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Address;Arrhythmia;biobank;bioinformatics tool;Biological Assay;Candidate Disease Gene;Cardiac Myocytes;cascade genetic testing;Catalogs;Cessation of life;Classification;Classification Scheme;Clinical;clinical care;Clinical Data;clinical phenotype;Code;commercialization;Computer Analysis;Computer Models;Correlative Study;cost;Coupled;Data;Data Set;Databases;Decision Making;Disease;exome;fitness;Frequencies;functional genomics;Genes;Genetic;genetic testing;genetic variant;genome wide association study;genomic data;Genomics;Genotype;Heart;Heart Abnormalities;Individual;induced pluripotent stem cell;innovation;insight;interdisciplinary approach;Ion Channel;Knowledge;Link;Long QT Syndrome;loss of function;Membrane Potentials;Methodology;Methods;Modeling;Molecular Computations;molecular dynamics;molecular modeling;mortality risk;multiplex assay;mutation screening;novel;Nucleic Acid Regulatory Sequences;Other Genetics;Outcome Study;Pathogenicity;phenomics;Phenotype;Physiological;Play;Potassium Channel;predictive modeling;Proteins;Reporting;Reproducibility;Research;Resources;Rest;Risk;Role;Running;sex;Speed;Structure;sudden cardiac death;Sudden Death;Syndrome;Techniques;Technology;Time;Trans-Omics for Precision Medicine;usability;Variant;variant of unknown significance;Work

PROJECT_TITLE: Deep Mutational Scanning and Functional Analysis of Repolarization Determinants

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: LM

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Overall Core Project Narrative As the Region 1 RML for the 2021-2026 Cooperative Agreement, the University of Maryland, Baltimore (UMB) proposes an ambitious program that includes social justice, health and digital equity, environmental health, and cultural humility topics in all training, funding and engagement opportunities for NNLM members. Done in tandem with responsive health, data, and digital literacy programming, the reach and impact of the National Library of Medicine (NLM) expands for all populations and audiences and advances the mission of the Network of the National Library of Medicine (NNLM). Thinking nationally and acting regionally, the RML Team integrates the latest evidence-based research and replicable community-driven health outreach programs to improve health and digital equity, integrating principles of Diversity, Equity and Inclusion (DEI) in all activities.

PI_NAMEs: HURST, EMILY  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Awareness;Baltimore;Communities;cultural health;Data;Data Set;Development;digital;Diverse Workforce;Effectiveness;effectiveness measure;Environmental Health;Equity;equity, diversity, and inclusion;evidence base;Funding;Funding Opportunities;Health;health equity;health literacy;Health Personnel;Health Professional;Health Sciences;Human;improved;Information Resources;innovation;Intervention;Library Services;literacy;Maryland;Medical Libraries;Medicine;member;Mission;outreach;outreach program;outreach services;Population;programs;Public Health;Research;Research Personnel;Resources;Social Justice;Structure;success;Thinking;Training;training opportunity;Trust;U-Series Cooperative Agreements;Underrepresented Populations;United States National Library of Medicine;Universities;Vision;Work

PROJECT_TITLE: Network of the National Library of Medicine Region 1


PI_NAMEs: NGUYEN, TONY T. (contact)

PROJECT_TERMS: Address;Baltimore;Collaborations;Communication;Communities;Data;Disasters;Emergency response;Emergency Situation;Ensure;Equity;equity, diversity, and inclusion;Evaluation;experience;Goals;Guidelines;Health;health equity;improved;interest;Intervention;Leadership;Libraries;Maryland;Measures;member;Mission;Monitor;operation;organizational structure;outreach;outreach program;Performance;Program Evaluation;programs;Readiness;recruit;resilience;Resources;satisfaction;Seasons;Services;Shapes;skills;Social Justice;Social Work;Structure;success;tool;Trust;Underrepresented Populations;United States National Library of Medicine;Universities

PROJECT_TITLE: Network of the National Library of Medicine Region 1 Administrative Core


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Advocate;career;career preparation;certificate program;Collaborations;Communication;Communities;community organizations;Creativeness;cultural health;Data;data literacy;Dedications;Development;digital;Diverse Workforce;Education;Educational Curriculum;end of life care;Ensure;Environmental Health;Equity;Fostering;Funding;Goals;Health;health equity;Health Personnel;Health Professional;Hospitals;improved;Information Resources;innovation;Intervention;Libraries;member;Modeling;Monitor;outreach;programs;Public Health;Research;Research Personnel;Resources;Social Justice;student participation;success;symposium;Technology;Training;Training Programs;Underrepresented Populations;United States National Library of Medicine;virtual;Work

PROJECT_TITLE: RML Core


NIH_SPENDING_CATS: Aging;Clinical Research;Kidney Disease

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Kidney function is typically estimated using serum creatinine, although this may be less reliable at the extremes of muscle mass; Dr. Potok’s preliminary work demonstrated that the difference in estimated glomerular filtration rate by cystatin C (eGFRCys) vs. creatinine (eGFRCr) holds information on functional status, frailty, and risk of death in older adults. The objective of this proposal is to determine the clinical applications of this difference (eGFRDiff = eGFRCys – eGFRCr), in terms of both prognosis and treatment. Results from this study will provide arguments to change nephrologists’ behavior regarding referral for dialysis preparation, and to change which marker between serum creatinine and cystatin C should be trusted to estimate kidney function when dosing medications.

PI_NAMEs: POTOK, OLIVIA ALISON (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Address;aged;Aging;American;authority;Behavior;Biometry;biracial;California;Cardiovascular Diseases;career;Cessation of life;Chronic Kidney Failure;Clinic;Clinical;clinical application;Clinical Research;Clinical Trials;clinically relevant;cohort;Creatinine;Data;design;Dialysis patients;Dialysis procedure;disorder risk;Dose;Elderly;End stage renal failure;Epidemiology;Equation;Ethnic Population;European;Event;experience;Fistula;frailty;functional status;Geriatrics;Glomerular Filtration Rate;Goals;Grant;Health;Heterogeneity;high risk;Hospitalization;Hospitals;human old age (65+);Implant;improved;Individual;individual patient;insight;Kidney Diseases;Kidney Failure;Learning;Manuscripts;Measures;Medicine;Mentors;Mentorship;Methods;Monitor;mortality;mortality risk;multi-ethnic;multidisciplinary;muscle form;Nephrology;older adult;older patient;Outcome;Participant;Patients;Persons;Pharmaceutical Preparations;Pharmacology;Population;post gamma-globulins;Preparation;professor;Prognosis;prognostication;prototype;Reasons for Geographic And Racial Differences in Stroke;reduced muscle mass;Renal function;Renal Replacement Therapy;Research;Research Personnel;Risk;Sample Size;Serum;skills;Spinal cord injury;Statistical Methods;surgical risk;Testing;tool;Training;Trust;Universities;Vancomycin;Washington;Work;Writing

PROJECT_TITLE: The Clinical Applications of the Difference in Estimated Glomerular Filtration Rate by Cystatin C vs. Creatinine (eGFRDiff)

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Heart Disease;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE Clinical trials are a critical step in translating discoveries into better treatments for people burdened by cardiac disorders. Such trials typically require cooperation and coordination among a broad range of investigators, patients, government agencies, and industry partners. The objective of the Cardiothoracic Surgical Trials Network (CTSN) is to increase the effectiveness and efficiency of clinical research through shared infrastructure for important trials that will advance therapy for patients suffering from cardiac disease.

PI_NAMEs: GELIJNS, ANNE CHRISTINE (contact);MOSKOWITZ, ALAN J

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Address;adjudication;Administrative Coordination;Adoption;Agreement;Ancillary Study;Atrial Fibrillation;biobank;Canada;Cardiac Surgery procedures;Cardiovascular system;Clinical;clinical center;clinical infrastructure;Clinical Investigator;clinical practice;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Collaborations;Collection;Communication;Data;Data Analytics;Data Collection;Data Coordinating Center;data integration;data integrity;data management;Data Management Resources;data quality;data sharing;design;Disease;Effectiveness;electronic data;electronic data capture system;Electronic Health Record;Eligibility Determination;Enrollment;Ensure;Event;evidence base;experience;Fostering;Funding;Goals;Government Agencies;Guidelines;Health;Health Insurance Portability and Accountability Act;Heart Diseases;Heart failure;implementation research;implementation science;improved;Industry;industry partner;Information Technology;Infrastructure;innovation;Institutional Review Boards;interest;International;international center;Investigation;Journals;large datasets;Leadership;Link;Longterm Follow-up;Manuscripts;Mediation;Medicine;meetings;mobile application;Monitor;Multicenter Studies;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;Natural Language Processing;Neuroprotective Agents;new technology;novel;novel therapeutics;Online Systems;Operative Surgical Procedures;Outcome;Pathway Analysis;patient oriented;Patient Recruitments;Patients;performance site;Persons;Play;Positioning Attribute;Practice Guidelines;Preparation;Process;Productivity;prospective;Protocols documentation;Publications;Publishing;quality assurance;Quality of life;recruit;Regenerative Medicine;Registries;Reporting;Research;research clinical testing;Research Personnel;Resources;Review Committee;Role;Safety;Sample Size;screening;Secure;Serious Adverse Event;Site;Source;Statistical Data Interpretation;thrombotic;tool;Training;Translating;trial design;United States National Institutes of Health;Visit;wearable sensor technology;Work

PROJECT_TITLE: Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Accountability;Address;Architecture;Baltimore;Collaborations;data sharing;Diverse Workforce;Education;Ensure;equity, diversity, and inclusion;Feedback;Funding;Goals;Health;Human;improved;Information Resources;Information Services;Information Technology;innovation;interest;Internet;Leadership;Life Cycle Stages;Maryland;Measurable;Medical Libraries;member;Mission;Policies;programs;Resource Sharing;Security;Structure;support network;System;tool;United States Dept. of Health and Human Services;United States National Library of Medicine;Universities;Vision;web services

PROJECT_TITLE: NNLM Web Services Office (NWSO)


NIH_SPENDING_CATS: Clinical Research;Food Allergies;Lung

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative/Biomedical Relevance Food allergies are a risk factor for asthma, and the natural history of allergic diseases suggests immunological crosstalk between mucosal organs contributes to the co-occurrences of allergic diseases within the same individual, although the cellular and molecular mechanisms that underly this process have not been defined. Building on our novel data demonstrating that dysregulation of lung tissue eosinophils is associated with allergic priming of the airways following allergen ingestion, this proposal will flesh out the mechanisms of the gut-lung crosstalk that dysregulates lung eosinophils and exacerbate allergic susceptibility of remote airways. Completion of this proposal may offer important insights into the mechanisms that drive mucosal organ crosstalk and as such is highly relevant to the development of better diagnostic and therapeutic approaches for patients with allergic diseases.

PI_NAMEs: SPENCER, LISA ANN (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Adaptor Signaling Protein;Adhesives;Adoptive Transfer;Affect;Allergens;Allergic;Allergic Disease;Allergic inflammation;Anatomy;Antigens;Asthma;Biological Assay;Biological Markers;Blood Vessels;CCL11 gene;Cells;Centers for Disease Control and Prevention (U.S.);Clinical;Coculture Techniques;cytokine;Data;Deposition;Detection;Development;Diagnostic;Distant;Dose;Economic Burden;Environment;eosinophil;eosinophilic inflammation;extracellular vesicles;Extrinsic asthma;Food Hypersensitivity;Frequencies;gene induction;Gene Modified;Generations;Genes;genetic signature;gut-lung axis;Health;Homeostasis;Homing;Hour;Human;IL5RA gene;Immune;Immune response;Immunity;Immunologics;In Vitro;in vivo;Individual;Inflammatory;Inflammatory Response;Ingestion;Inhalation;innovation;insight;Integrins;Interleukin-13;Interleukin-5;Intervention;Intestines;Intrinsic factor;ITGAM gene;Knowledge;Lung;Lymphoid Cell;Mediating;Mediator;Metaplasia;migration;Molecular;mouse model;Mouse Strains;Mucous body substance;Mucous Membrane;Mus;nanoflow cytometry;nanoparticle;Natural History;neutralizing antibody;novel;Oral;Organ;Ovalbumin;Patients;Persons;Phenotype;Predisposition;Prevalence;Process;Pyroglyphidae;receptor;recruit;Reporter;response;Risk Factors;Role;Serum;Serum Proteins;Signal Transduction;Site;Skin;Standard Model;Stomach;Structure of parenchyma of lung;Surface;T-Lymphocyte;Testing;Therapeutic;Tissues;transcriptome;translational approach;TSLP gene;Up-Regulation;Wild Type Mouse

PROJECT_TITLE: Cellular and molecular mechanisms of mucosal organ crosstalk in allergic diseases

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Substance Misuse

PHR: The NA-ACCORD is the most wide-ranging and in-depth collaboration of HIV cohorts that exists within North America. Its large sample size, the comprehensiveness and quality of its data, combined with the expert use of state-of-the-art statistical methods will allow us to provide answers to the most pressing questions of contemporary importance for the care and outcomes of people with HIV in the US and Canada. The questions will inform the End the HIV Epidemic initiative and provide important information on the long-term course of HIV disease.

PI_NAMEs: ALTHOFF, KERI NICOLE (contact);MOORE, RICHARD DOUGLAS

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adult;AIDS prevention;American;Basic Science;Benchmarking;Biometry;Canada;cancer therapy;Cardiovascular Diseases;care delivery;Caring;Clinical;clinical care;Clinical Data;clinical investigation;Clinical Research;clinical research site;co-infection;cohort;Collaborations;Communities;comorbidity;Continuity of Patient Care;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Science;data visualization;demographic disparity;design;Development;Diagnosis;Disease;Electronic Health Record;Epidemic;Epidemiology;follow-up;Funding;Future;geographic disparity;Geography;Goals;Guidelines;Heterogeneity;HIV;HIV Infections;HIV/AIDS;Impaired cognition;implementation science;Income;Individual;Inequality;Informatics;Infrastructure;International;Intervention;Kidney Diseases;Life Expectancy;Liver diseases;longitudinal course;machine learning algorithm;Mental Health;Metabolic Diseases;Methodology;Methods;Monitor;multidisciplinary;multiple chronic conditions;Neighborhoods;North America;Outcome;Patient Care;Persons;Policies;Policy Maker;Polypharmacy;Positioning Attribute;Productivity;prognostic;Prognostic Factor;programs;Public Health;Research;Research Personnel;response;Risk Factors;RNA;Sample Size;Scientific Advances and Accomplishments;Secondary Prevention;Sensitivity and Specificity;Site;social health determinants;Statistical Methods;substance use;Talents;Testing;Time;Toxic effect;transmission process;trend;United States Dept. of Health and Human Services;Viral

PROJECT_TITLE: North American AIDS Cohorts on Collaboration and Design (NAACCORD)


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Health Services;Rare Diseases

ORG_DEPT: SURGERY

PHR: Project Narrative (Public Health Relevance) Overdiagnosis of thyroid cancer is a significant problem that compromises patients’ quality of life, leading to overtreatment, exposure to unnecessary risk, and high medical costs. The objective of this research is to identify factors that predispose people to being diagnosed with thyroid cancer that would never cause symptoms or death if undetected, so the healthcare system can instead focus resources on thyroid cancers that would result in morbidity if untreated. Results of the model will help to inform clinical practice guidelines and referral practice recommendations to improve the quality of health care while reducing inappropriate testing, to minimize overdiagnosis and overtreatment.

PI_NAMEs: ALAGOZ, OGUZHAN ;FRANCIS, DAVID O. (contact)

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: Accounting;Address;Age;Anxiety;Biological;Biopsy;Breast;Calibration;cancer diagnosis;cancer epidemiology;Cancer Model;cancer site;Categories;Cessation of life;Classification;Clinical;Clinical Practice Guideline;Clinical Trials;clinically relevant;Colorectal;Communication;Conceptions;Data;Death Rate;Development;Diagnosis;Diameter;Disease;dissemination strategy;Engineering;Ensure;Exposure to;Face;follow-up;Goals;Growth;Guidelines;Health Care Costs;health care quality;health care service utilization;Health Policy;Health Services Research;Healthcare Systems;high risk;Histologic;Image;improved;Incidence;Industrialization;innovation;Intervention;Knowledge;Lesion;Lung;Machine Learning;Malignant neoplasm of thyroid;Malignant Neoplasms;mathematical model;Medical Care Costs;Methods;Mission;model development;Modeling;models and simulation;Morbidity - disease rate;mortality;multidisciplinary;National Cancer Institute;Natural History;Nodule;Non-Malignant;novel;Outcome;Output;overtreatment;Papillary thyroid carcinoma;Patient imaging;patient population;patient subsets;Patients;Pattern;Persons;Policy Maker;Predisposing Factor;Procedures;Prostate;Provider;public health relevance;Qualifying;Quality of life;Quality-Adjusted Life Years;Recommendation;Research;Resources;Risk;sex;side effect;Symptoms;System;Testing;Thyroid Gland;thyroid neoplasm;Time;tumor growth;ultrasound;unethical;United States;Validation;virtual;virtual laboratory;Withholding Treatment

PROJECT_TITLE: Estimating and Mitigating Thyroid Cancer Overdiagnosis: A Mathematical Modeling Approach

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Trauma continues to be a leading cause of death and disability in the USA. The Program aims to train surgical residents or recently graduated PhDs as the next generation of Trauma Scientists, capable of bringing advances in the understanding of the underlying mechanisms of “trauma disease” and inflammation to the bedside and improve the outcome of trauma victims.

PI_NAMEs: AYALA, ALFRED  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: Inflammation;Research Training;Trauma

PROJECT_TITLE: Trauma and Inflammation Research Training


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Electrical signaling in myelinated axons requires ion channel clustering at axon initial segments (AIS) and nodes of Ranvier, and a robust axonal cytoskeleton. However, the molecular mechanisms regulating the functional organization of axons remain poorly understood. Here, we will use discovery proteomics and rigorous analysis of strategically designed genetic mouse models to discover these mechanisms.

PI_NAMEs: RASBAND, MATTHEW N (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Action Potentials;Ankyrins;Architecture;Axon;conditional knockout;Cytoskeletal Proteins;Cytoskeleton;design;Disease;Dissection;Electrophysiology (science);experimental study;gain of function;Genetic;Health;Image;Impairment;Injury;Ion Channel;Knockout Mice;loss of function;Maintenance;Methods;Modernization;Molecular;mouse model;Natural regeneration;Nervous System;Nervous System Physiology;Neurons;preservation;Proteins;Proteomics;Ranvier's Nodes;repaired;Research;Signal Transduction;Spectrin;Structure;Therapeutic

PROJECT_TITLE: The Molecular Architecture of Axons in Health and Disease