NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences

PI_NAMEs: BRUCHAS, MICHAEL R. (contact)

PROJECT_TERMS: Acute;acute stress;Affective;Anatomy;Anhedonia;Animals;antagonist;Anterior;Anxiety;Anxiety Disorders;anxious behavior;approach/avoidance behavior;Autopsy;Aversive Stimulus;avoidance behavior;Behavior;Behavioral;behavioral response;Biological;Biological Assay;Biological Process;Brain region;Calcium;Cell Communication;Cell Nucleus;cell type;Cells;Characteristics;Chronic stress;cingulate cortex;Collaborations;Complex;Computer Models;Corpus striatum structure;Cre driver;Cues;Data;Decision Making;Depressive disorder;depressive symptoms;Disease;Dopamine;dopamine system;dopaminergic neuron;Dorsal;efficacious treatment;Excision;experimental study;Exposure to;Fiber;Functional disorder;G Protein-Coupled Receptor Signaling;Genetic;Goals;Habenula;Heterogeneity;Human;Image;improved;in vivo;Individual;insight;Internal Ribosome Entry Site;interpeduncular nucleus;Investigation;Link;Major Depressive Disorder;Medial;Mediating;Mental Depression;mesolimbic system;Midbrain structure;Modeling;Mood Disorders;motivated behavior;Motivation;mouse model;Mus;negative affect;Negative Valence;neural;neural circuit;neurobiological mechanism;Neurons;Neuropeptides;nociceptin;Nociception;nonhuman primate;novel;Opioid;optogenetics;Organism;ORL1 receptor;Pathway interactions;pharmacologic;Photometry;Play;Population;preference;prepronociceptin;Process;Psychopathology;receptor;Regulation;Research;response;Rewards;Role;Specificity;Stimulus;Stress;stressor;Sucrose;Suicide;synergism;System;Tail Suspension;Techniques;Testing;Ventral Tegmental Area;Viral

PROJECT_TITLE: Project 4_Bruchas : Circuit-level Approaches for Dissecting Approach/Avoidance Behaviors Mediated by Nociceptin Systems in Mice


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PI_NAMEs: SKAAR, ERIC P (contact)

PROJECT_TERMS: adaptive immune response;Address;Adherence;Adult;Anaerobic Bacteria;Animals;anti-toxin;Antibiotic Resistance;Antibiotics;Antibodies;antigen binding;Antigen Targeting;Antigens;Attenuated;B-Lymphocytes;Bacteria;Bacterial Vaccines;bactericide;Binding;Biochemical;Biotin;Biotinylation;candidate identification;Clinical;Clostridioides difficile vaccine;Clostridium difficile;Collaborations;Colon;Communities;cost;Diarrhea;Disease;efficacy testing;Elderly;enteric infection;Enzyme-Linked Immunosorbent Assay;Epitopes;Evaluation;experimental study;fitness test;gene product;Genetic;genetic approach;genetic selection;Goals;gut colonization;health care settings;Hospitals;Human;Immune response;Immune system;Immunization;Immunocompromised Host;immunogenicity;Immunoglobulin A;Immunoglobulin G;in vivo;Incidence;Individual;Infection;innovation;Label;Lead;Libraries;Ligase;Link;Location;Mass Spectrum Analysis;Mediating;Membrane Proteins;Memory B-Lymphocyte;Methods;Modeling;mouse model;Mus;mutant;novel;Organism;Output;pathogen;Patients;Peripheral Blood Mononuclear Cell;Population;pre-clinical;preclinical trial;prevent;Process;programs;Proteins;Pseudomembranous Colitis;Public Health;Recurrence;Recurrent disease;Reproduction spores;resistant strain;response;Role;safety testing;saliva sample;Sampling;Serum;Severities;Signal Transduction;Sorting;stem;success;Surface;Symptoms;Testing;Toxin;Toxoids;transposon sequencing;United States;unvaccinated;Vaccinated;Vaccination;Vaccine Antigen;vaccine candidate;vaccine discovery;vaccine safety;vaccine trial;Vaccines;Validation;Virulent;Zoonoses

PROJECT_TITLE: Project 2: Discovery of novel C. difficile antigens using genetic and biochemical approaches


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Alliance Statistics and Data Management Center PROJECT NARRATIVE The Alliance Statistics and Data Management Center is responsible for the statistical, data management, and information technology activities that support the scientific agenda of the Alliance for Clinical Trials in Oncology, a national cancer research organization. Successful execution of these activities had led to and will continue to lead to the translation of basic and clinical research into trials of new therapies that have the potential to change clinical practice, resulting in improved outcomes for cancer patients world-wide.

PI_NAMEs: MANDREKAR, SUMITHRA JAY (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Academic Medical Centers;Ally;American College of Surgeons Oncology Group;anti-cancer research;Basic Science;Bioinformatics;Biological Markers;Cancer and Leukemia Group B;cancer clinical trial;Cancer Patient;Cancer Therapy Evaluation Program;Cessation of life;Clinic;Clinical;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Community Practice;Computer software;Conduct Clinical Trials;Correlative Study;Data;data centers;Data Collection;Data Coordinating Center;data management;data quality;data sharing;design;Development;Discipline;editorial;electronic data;Ensure;Evaluation;Faculty;flexibility;follow-up;genomic biomarker;genomic predictors;Goals;improved outcome;individual patient;Information Systems;Information Technology;Infrastructure;innovation;instrument;International;Leadership;Location;Manuscripts;Medical;Medidata;member;Meta-Analysis;Methodology;Methods;Mission;Monitor;North Central Cancer Treatment Group;novel;novel therapeutics;Oncologist;Oncology;Oncology Group;operation;Operative Surgical Procedures;Paper;Pathologist;Patients;Phase I Clinical Trials;Policies;Positioning Attribute;Precision Medicine Initiative;Preparation;Procedures;Process;programs;prospective;Publications;Publishing;quality assurance;Radiation;radiologist;Randomized;Regulation;Reporting;Research;Research Personnel;Resource Allocation;Retrospective Studies;Sample Size;Scheme;Science;Scientist;Secure;Source;statistical center;Statistical Methods;statistics;Structure;Support System;Surrogate Endpoint;System;Technology;Time;timeline;tool;Training Programs;Translational Research;Translations;treatment trial;United States


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Elucidating the molecular mechanisms of alveolar formation is key to understanding the pathogenesis of lung diseases caused by immaturity or loss of alveoli. Such endeavors will also provide potential new therapies by stimulating alveolar formation.

PI_NAMEs: CHUANG, PAO-TIEN  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Ablation;Actomyosin;Adult;Alveolar;Alveolus;Antibodies;Area;autonomic nerve;Autonomic nervous system;Behavior;calcium indicator;Cell Communication;Cell Line;Cells;Coculture Techniques;Cytoskeleton;Defect;density;Development;Distal;Enzymes;Excision;fetal;Fiber;Human;Immunofluorescence Immunologic;inducible Cre;Investigation;Knowledge;Label;Ligands;Lung;lung development;Lung Diseases;Mediating;Methodology;migration;Modeling;Molecular;Monitor;Mus;Myofibroblast;Natural regeneration;Neonatal;Nerve;Nerve Block;Nerve Fibers;Nerve Growth Factor Receptors;nerve supply;Neural Crest;Neural Crest Cell;Neuromuscular Junction;Neurons;Neurotransmitter Receptor;neurotransmitter release;neurotransmitter transport;Neurotransmitters;neurotrophic factor;novel;novel therapeutics;Output;Pathogenesis;PC12 Cells;planar cell polarity;Play;Process;progenitor;Proliferating;receptor;reinnervation;Role;Saccule structure;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Tamoxifen;Testing;Tetanus Toxin;Time;trafficking;transcriptome sequencing;Work

PROJECT_TITLE: Autonomic innervation regulates alveolar formation in development

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Suicide

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

ORG_STATE: MA

PI_NAMEs: FRANK, MICHAEL J. (contact)

PROJECT_TERMS: Acute;Affect;Anhedonia;Animal Experiments;antagonist;Anxiety;Anxiety Disorders;approach/avoidance behavior;Basal Ganglia;Behavior;Behavioral;Benchmarking;Biological Markers;Brain;Chronic stress;Classification;Clinical;clinical predictors;cognitive neuroscience;Complement;computer framework;Computer Models;Conflict (Psychology);Corpus striatum structure;Data;Decision Making;Deep Brain Stimulation;depressive symptoms;Diagnosis;Diffusion;Dimensions;Disease;Electrocorticogram;Epilepsy;experience;frontal lobe;functional magnetic resonance imaging/electroencephalography;Goals;Graph;Human;improved;Incentives;Individual;Investigation;Learning;Link;Machine Learning;machine learning classification;machine learning method;Maps;Measures;Mental Depression;Methods;microstimulation;Modeling;Mood Disorders;Motivation;neural;neural correlate;neural network;neuromechanism;neurotransmission;nociceptin;nonhuman primate;novel;Parameter Estimation;Patients;Pharmaceutical Preparations;Phenotype;Physiological;Population;Process;Psychiatry;psychologic;Reaction Time;response;Rewards;Rodent;Rodent Model;Sampling;Sensitivity and Specificity;Severities;Shapes;Signal Transduction;Site;statistics;Stress;stressor;Study models;suicidal;Symptoms;System;Task Performances;Testing;Therapeutic;Translations;Universities;Validation;Variant

PROJECT_TITLE: Computational Modeling Core_Frank


NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases;Liver Disease;Vector-Borne Diseases

ORG_CITY: MILWAUKEE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Schistosomiasis is an infectious parasitic disease afflicting ~200 million people worldwide. Current therapy depends on a single drug (praziquantel) with an unknown mechanism of action despite 40 years of clinical use. Our laboratory recently identified targets for praziquantel action that will allow praziquantel binding sites to be defined and pharmacologically exploited in both the parasite and infected human host to treat this disease.

PI_NAMEs: MARCHANT, JONATHAN S (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acute;Adult;Agonist;Anemia;Anthelmintics;Antiparasitic Agents;Architecture;Beds;Binding;Binding Sites;Biology;Bladder;Blood Vessels;burden of illness;Chronic;Clinical;clinical efficacy;clinically significant;comorbidity;Coupled;Data;Deposition;design;Development;disability-adjusted life years;Disease;drug action;drug development;Drug Interactions;egg;enantiomer;Exhibits;Fibrosis;Formulation;G-Protein-Coupled Receptors;gastrointestinal;Granuloma;Growth;Helminths;Hepatic;Hepatic Stellate Cell;HIV Infections;Human;Hypertension;Immune response;improved;In Vitro;in vivo;Infection;Inflammatory;insight;Intestines;Ion Channel;Knowledge;Laboratories;Left;Length;Life Cycle Stages;Ligands;Liver;Liver diseases;Malnutrition;Maps;Mesentery;Molecular;neglected tropical diseases;next generation;novel;Outcome;Parasites;Parasitic Diseases;Parasitic infection;Pathology;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Physiology;Platyhelminths;Population;Praziquantel;Praziquantel resistance;prevent;Property;Publishing;rational design;Reaction;receptor;Refractory;Resolution;Risk;Route;Schistosoma;Schistosomatidae;Schistosomiasis;screening;Serotonin;Serotonin Receptor 5-HT2B;Signal Pathway;Signal Transduction;spastic paralysis;Structure;Tetrahydroisoquinolines;Therapeutic;Tissues;TRP channel;Urogenital Diseases;Variant;Work

PROJECT_TITLE: Identification of targets of the antiparasitic drug praziquantel

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Microbiome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PI_NAMEs: FRANKLIN, CRAIG L (contact)

PROJECT_TERMS: Antigens;assay development;Biocompatible Materials;Biomedical Research;Collection;Communicable Diseases;Communities;Complex;congenic;Cryopreservation;Derivation procedure;Development;Developmental Biology;developmental disease;Economics;Embryo;embryonic stem cell;Ensure;Equipment and supply inventories;experience;functional improvement;Genes;genetic analysis;Genetic Diseases;Genetically Engineered Mouse;Genotype;Germ;Germ Cells;Goals;gut microbiota;improved;Income;Karyotype determination procedure;Kinetics;Knock-out;Medicine;microbiome;microbiota;Missouri;Modeling;Monitor;mouse model;Mus;Mutant Strains Mice;pathogen;Pharmaceutical Preparations;Phenotype;programs;Reagent;repository;Reproducibility;Research;Research Personnel;Resources;Role;Sampling;Services;Speed;sperm cell;Standardization;Testing;Therapeutic;tissue stem cells;Tissues;tool;Universities

PROJECT_TITLE: The Mutant Mouse Resource and Research Center at the University of Missouri - Resource

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

PHR: The Alliance Statistics and Data Management Center is responsible for the statistical, data management, and information technology activities that support the scientific agenda of the Alliance for Clinical Trials in Oncology, a national cancer research organization. Successful execution of these activities had led to and will continue to lead to the translation of basic and clinical research into trials of new therapies that have the potential to change clinical practice, resulting in improved outcomes for cancer patients world-wide.

PROJECT_TERMS: American College of Surgeons Oncology Group;anti-cancer research;Basic Science;Bioinformatics;Biological Markers;Cancer and Leukemia Group B;cancer clinical trial;Cancer Patient;Cessation of life;Clinic;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Computer software;Correlative Study;Data;Data Coordinating Center;data management;data quality;Development;editorial;Evaluation;Faculty;follow-up;genomic biomarker;genomic predictors;improved outcome;individual patient;Information Systems;Information Technology;Infrastructure;innovation;International;Leadership;Location;Manuscripts;Medidata;member;Methodology;Methods;Mission;Monitor;North Central Cancer Treatment Group;novel;novel therapeutics;Oncology;Oncology Group;operation;Paper;Patients;Phase I Clinical Trials;Positioning Attribute;Precision Medicine Initiative;Preparation;Procedures;programs;prospective;Publications;Publishing;Reporting;Retrospective Studies;Source;statistics;Surrogate Endpoint;System;Technology;timeline;tool;Translations;treatment trial

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Regenerative Medicine;Wound Healing and Care

ORG_CITY: Los Angeles

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative: We seek to learn how to harness the ability of ion channels and electric fields in tissue development and regeneration. To this end, we will explore the role of ion channels and bioelectric fields in guiding tissue development using two avian skin morphogenesis models: 1) the orientation of feather bud elongation along the anterior – posterior axis, 2) the patterning of alternating yellow and black longitudinal pigment stripes in Japanese quail.

PI_NAMEs: CHOW, ROBERT HSIU-PING;CHUONG, CHENG-MING ;WIDELITZ, RANDALL BRUCE (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Affect;Anterior;appendage;Architecture;Back;Biochemical;bioelectricity;Biophysics;Birds;Calcium Channel;Calcium Oscillations;cell behavior;cell motility;Cells;Complex;Coturnix japonica;Coupled;Dermal;Development;Diffusion;electric field;electropotential;Embryo;Evaluation;Feathers;Feedback;Fibroblast Growth Factor;Future;Gap Junctions;Gene Activation;Genetic Transcription;Giant Cells;Hair;inhibitor;insight;Ion Channel;Learning;Mammals;Maps;melanocyte;meter;millimeter;millisecond;Modeling;Morphogenesis;morphogens;mouse model;multidisciplinary;Natural regeneration;novel;optogenetics;Organ;Paper;Pattern;Pattern Formation;Periodicals;Phenotype;Pigmentation physiologic function;Pigments;Play;Process;progenitor;programmed cell death protein 1;Quail;Reaction;Readability;recruit;Regenerative wound healing;Research;Role;Signal Transduction;Skin;skin morphogenesis;skin organogenesis;skin regeneration;stem cell population;Structure;Study models;success;Time;Tissues;Translating;transmission process;vector;Visualization;Work;wound;wound healing

PROJECT_TITLE: Channel activity during skin morphogenesis


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Infant Mortality;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: The worldwide mortality from perinatal hypoxic–ischemic (HI) injury reached 1.15 million in 2010. Perinatal HI brain injury also causes long-term neurological disability and morbidity in infants. Our project is focused on the novel, unexplored cause and mechanism of tissue damage in the brain after oxygen deprivation and proposed studies will unravel potential pharmacological targets for improving the outcome of ischemia/reperfusion and our results also help to establish a mechanistic basis of hypothermic neuroprotection in HI-reperfusion.

PI_NAMEs: GALKIN, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acute;Adult;Affect;Astrocytes;Attenuated;attenuation;Automobile Driving;Binding;Bioenergetics;Blood;Brain;Brain Hypoxia-Ischemia;Brain Injuries;Brain Ischemia;brain tissue;Cell Culture Techniques;cell type;Cells;Cerebral Palsy;Cessation of life;Citric Acid Cycle;Clinical Research;cofactor;cold temperature;Complex;Consumption;Data;deprivation;Development;Dissociation;Drops;Electron Transport;Energy Metabolism;enzyme activity;Enzymes;Event;Exhibits;experimental study;Failure;Flavin Mononucleotide;Flavins;Functional disorder;Generations;Glucose;Glycolysis;Health;Hour;Human;hypoxic ischemic injury;Hypoxic-Ischemic Brain Injury;Impairment;improved outcome;In Vitro;in vivo;Infant;Ischemia;Kinetics;life time cost;Measures;Membrane;Membrane Potentials;Metabolic;Metabolic Pathway;Methods;Mitochondria;Modeling;Molecular;Morbidity - disease rate;Mus;natural hypothermia;Necrosis;Neonatal;neonatal brain;neonatal hypoxic-ischemic brain injury;neonatal mice;Neurological disability;Neurons;neuroprotection;novel;oxidation;Oxidative Stress;Oxygen;Pathway interactions;Patients;Perinatal anoxic ischemic brain injury;Perinatal Hypoxia;Perinatal mortality demographics;Permeability;pharmacologic;Phosphocreatine;pre-clinical;preservation;prevent;Process;Production;Reactive Oxygen Species;Recovery;Reperfusion Injury;Reperfusion Therapy;Respiration;response;Riboflavin;Role;Secondary to;Severities;Specificity;Stroke;stroke model;Succinates;System;Temperature;Testing;Therapeutic;Time;Tissues;Work

PROJECT_TITLE: The Role of FMN Loss by Mitochondrial Complex I in Neonatal Hypoxic-Ischemic Brain Injury


PI_NAMEs: ERICSSON, AARON  (contact)

PROJECT_TERMS: Antibody Formation;Antigens;Appearance;Applied Research;Archives;Bacteria;base;Biological Models;biological systems;Biomedical Research;biosecurity;Caring;Collaborations;Communicable Diseases;Communities;Data;Development;dextran sulfate sodium induced colitis;Disease;disease model;Disease susceptibility;experience;experimental group;Exposure to;Generations;Genetic;Genotype;gut inflammation;gut microbiota;Helicobacter hepaticus;Human;human disease;human model;Immune response;Immunoglobulins;Immunophenotyping;Inbred NOD Mice;Income;Individual;infectious disease model;innovation;Institution;Insulin-Dependent Diabetes Mellitus;interest;Laboratory mice;Memory;Methods;Microbe;microbial;microbial community;microbiota;Missouri;model organism;Modeling;mouse model;Murine hepatitis virus;Mus;Mutant Strains Mice;novel;Outcome;pathobiont;pathogen;pathogenic fungus;Pathogenicity;Peripheral;Phenotype;Physiological;Predisposition;Process;Production;programs;protective effect;Protozoa;Publishing;Recording of previous events;Reproducibility;Research;Research Personnel;Resources;Services;Severities;Surveys;T memory cell;Testing;The Jackson Laboratory;therapeutic development;Time;Toxic effect;translational model;tumorigenesis;Universities;Viral;wasting;worker safety

PROJECT_TITLE: The Mutant Mouse Resource and Research Center at the University of Missouri - Applied Research Section 1


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: American College of Surgeons Oncology Group;anti-cancer research;Basic Science;Bioinformatics;Biological Markers;Cancer and Leukemia Group B;cancer clinical trial;Cancer Patient;Cessation of life;Clinic;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Computer software;Correlative Study;Data;Data Collection;Data Coordinating Center;data management;data quality;design;Development;editorial;Evaluation;Experimental Designs;Faculty;follow-up;genomic biomarker;genomic predictors;improved outcome;individual patient;Information Systems;Information Technology;Infrastructure;innovation;International;Leadership;Location;Manuscripts;Medidata;member;Methodology;Methods;Mission;Monitor;multidimensional data;North Central Cancer Treatment Group;novel;novel therapeutics;Oncology;Oncology Group;Paper;Patients;Phase I Clinical Trials;Positioning Attribute;Precision Medicine Initiative;Preparation;Process;prospective;Publications;Publishing;Randomized;Reporting;Research;Retrospective Studies;Sample Size;Scheme;Source;statistics;Surrogate Endpoint;System;Technology;timeline;tool;Translations;treatment trial;Validation

PROJECT_TITLE: Statistics Core


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: The major goal of the University of Iowa Virology Predoctoral Training Program is to produce outstanding independent virologists who will pursue careers in academic or other virology- related careers. Students in the program will spend 90% of their pursuing virology research under the supervision of a funded participating faculty member. Laboratory work will be supplemented by opportunities to hone their skills in data presentation and teaching.

PI_NAMEs: PERLMAN, STANLEY  (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Molecular Virology;Training;Viral Pathogenesis;Viral Vector

PROJECT_TITLE: Training in Molecular Virology, Viral Pathogenesis and Viral Vectors

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: NARRATIVE The work proposed in this grant will advance our understanding of the effects of an FDA approved drug, rapamycin, which has significant benefit in preventing or reversing age-related dysfunction. The results are critical to the safe use of this drug to prevent multiple diseases such as Alzheimer's disease, cardiac failure, and loss of immune function in the elderly.

PI_NAMEs: SELL, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: adult stem cell;age related;age-related disease;Aging;Alzheimer's Disease;Breeding;CCCTC-binding factor;CDKN2A gene;Cell Aging;Cell Compartmentation;cell type;Cells;chromatin modification;Clinical;clinical development;Complex;Cytoplasm;Data;Development;Disease;Drug usage;Elderly;extend lifespan;EZH2 gene;Family;FDA approved;FRAP1 gene;Functional disorder;gene repression;Genetic Transcription;Goals;Grant;H19 gene;healthy aging;Heart failure;Human;immune function;improved;in vivo;individual response;Inflammation;inhibitor;Intervention;Laboratories;late life;Longevity;Maintenance;Mediating;Mediator;member;Metabolic;MicroRNAs;Modeling;Monitor;mTOR inhibition;mTOR Inhibitor;Mus;novel;novel marker;Pathway interactions;Pharmaceutical Preparations;Phosphotransferases;Play;pluripotency;prevent;programs;promoter;Promoter Regions;Regulation;Reporter;Research;response;RNA;Role;senescence;senescent cell;side effect;Signal Transduction;Sirolimus;Somatic Cell;stem cell function;stem cell population;Testing;tissue stem cells;Tissues;TP53 gene;Untranslated RNA;Work;Zinc Fingers

PROJECT_TITLE: Novel longevity enhancing pathways regulated by mTOR

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Microbiome

PROJECT_TERMS: Animals;Antibiotics;Applied Research;Area;Award;Biocompatible Materials;Biomedical Research;Cells;Characteristics;cohort;Collaborations;Collection;colonization resistance;Communities;comparative;Complex;Data;Development;Discipline of Nursing;Disease;Embryo Transfer;Engineering;Ensure;Enterohepatic Circulation;Etiology;Experimental Designs;fecal microbiota;Feces;Filament;Fostering;Funding;Gastrointestinal Contents;Gastrointestinal tract structure;Germ-Free;gut microbiota;high reward;high risk;Human;Individual;innovation;Laboratory mice;Large Intestine;longitudinal animal study;Longitudinal Studies;Lower Gastrointestinal Tract;Medicine;member;metallicity;Methods;microbial;microbiota;microbiota profiles;Missouri;Molecular;Molecular Analysis;mouse model;Mus;Mutant Strains Mice;Neonatal;non-invasive system;nutrition;Oral;particle;Pathway interactions;Phenotype;Physiological Processes;Physiology;Polymers;Predisposition;Productivity;Prospective Studies;prospective test;R24;Reporting;Reproducibility;Research;Research Personnel;Resistance;Resources;Role;Sampling;Severity of illness;Small Business Innovation Research Grant;Small Intestines;Stomach;success;Surveys;System;Testing;Therapeutic;Time;tool;Translations;Universities;Upper digestive tract structure;virtual;Xenobiotics

PROJECT_TITLE: The Mutant Mouse Resource and Research Center at the University of Missouri - Applied Research Section 2


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Wound Healing and Care

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative We have discovered that the immune privilege status of the avascular tissues in the anterior segment has led to a unique response to eye trauma, injury and pathogenesis that involves the activation and recruitment of immune cells to the lens for the purpose of preserving/restoring homeostasis. With lineage tracing studies we will identify the ontogeny of lens tissue resident immune cells and of the immune cells recruited to the lens in response corneal wounding, and determine their immunomodulatory functions in maintaining anterior segment homeostasis following corneal wounding as well as in the inflammatory disease uveitis. We also will examine the potential harmful outcomes of the persistence of these lens associated immune cells in the development of eye pathologies including cataract and glaucoma.

PI_NAMEs: MENKO, A. SUE (contact);STEPP, MARY ANN

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TITLE: Paradigms of maintaining anterior segment homeostasis


PROJECT_TERMS: American College of Surgeons Oncology Group;anti-cancer research;Basic Science;Bioinformatics;Biological Markers;Cancer and Leukemia Group B;cancer clinical trial;Cancer Patient;Cessation of life;Clinic;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Computer software;Correlative Study;Data;Data Collection;Data Coordinating Center;data management;data quality;design;Development;editorial;electronic data;Ensure;Evaluation;Faculty;follow-up;genomic biomarker;genomic predictors;improved outcome;individual patient;Information Systems;Information Technology;Infrastructure;innovation;instrument;International;Leadership;Location;Manuscripts;Medidata;member;Methodology;Methods;Mission;Monitor;North Central Cancer Treatment Group;novel;novel therapeutics;Oncology;Oncology Group;Paper;Patients;Phase I Clinical Trials;Policies;Positioning Attribute;Precision Medicine Initiative;Preparation;Procedures;Process;prospective;Publications;Publishing;quality assurance;Regulation;Reporting;Retrospective Studies;Secure;Source;statistics;Support System;Surrogate Endpoint;System;Technology;timeline;tool;Training Programs;Translational Research;Translations;treatment trial

PROJECT_TITLE: Data Management Core


ORG_CITY: NEW ORLEANS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Studies are warranted to elucidate the genetic and biochemical underpinnings of lung squamous cell carcinoma (LUSC), the second most common lung cancer type. Based on the preliminary results presented here, we postulate that chromosome 3q amplification reshapes the Golgi secretory pathway and creates a therapeutic vulnerability of LUSC. Our findings could have broad relevance given that chromosome 3q is frequently amplified in multiple cancer types.

PI_NAMEs: TAN, XIAOCHAO  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: 3q26;Address;antitumor effect;ATP phosphohydrolase;Binding;Biochemical;Biogenesis;cancer cell;Cancer Etiology;cancer type;Cell Line;Cell membrane;Cell Survival;Cells;Cessation of life;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Conditioned Culture Media;Diploidy;driver mutation;Endosomes;gene-editing approach;Genes;Genetic;Golgi Apparatus;Growth;In Vitro;in vivo;Induction of Apoptosis;insight;Integral Membrane Protein;Knock-out;Label;liquid chromatography mass spectrometry;Lysosomes;Malignant Epithelial Cell;Malignant neoplasm of lung;Mediating;Mediator;Membrane;metastatic process;Molecular;Mus;Neoplasm Metastasis;novel therapeutics;Oncogenic;Pathway interactions;patient derived xenograft model;Phenocopy;Play;Process;programs;Protein Secretion;Protein Sortings;Proteins;Pump;reconstitution;repository;Role;Sampling;Secretory Vesicles;sensor;Shapes;small hairpin RNA;Small Interfering RNA;Somatic Mutation;Squamous Cell Lung Carcinoma;targeted treatment;Testing;Therapeutic;trafficking;tumor;tumor microenvironment;tumor progression;tumorigenic;Ubiquitin;Work

PROJECT_TITLE: An actionable secretory program that drives tumor progression in a genetically defined subset of lung squamous carcinoma


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Cystic Fibrosis;Genetics;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: This proposal is relevant to public health because it will reveal and characterize how important bacterial pathogens resist antibiotic treatment. We know that bacterial pathogens can form slow-growing, multicellular communities called biofilms that dramatically influence their susceptibility to clinically relevant antibiotics, but we know very little about whether and to what degree bacterial pathogens employ biofilms during infection. We expect the results of these experiments to yield short-term benefits in terms of treatment decisions for patients and long-term benefits in terms of providing the groundwork for novel therapeutic development.

PI_NAMEs: DEPAS, WILLIAM H. (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Affect;Agar;Air;Anoxia;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Automobile Driving;Bacteria;Biological Assay;Biological Models;Bioreactors;Carbon;CCRL2 gene;cell community;Cell Physiology;Cells;Chemicals;chronic infection;Clinical;clinically relevant;combat;Communities;Cystic Fibrosis;cystic fibrosis infection;cystic fibrosis patients;Cystic Fibrosis sputum;Dangerousness;Data;Development;Disease Progression;dosage;emerging pathogen;Environment;Experimental Designs;experimental study;fighting;Gene Expression;Gene Proteins;Genes;Genetic;genetic regulatory protein;Genetic Transcription;Genus Mycobacterium;Glutamine;Goals;Growth;Hibernation;Human;Immune response;In Situ;In Vitro;in vitro Assay;in vivo;Infection;innovation;insight;Libraries;Link;lung pathogen;Mediating;Metabolic;Metabolic Pathway;metabolomics;Microbial Biofilms;millimeter;Modeling;Molecular;Molecular Target;molecular targeted therapies;Mutagenesis;mutant;Mycobacterium abscessus;Mycobacterium Infections;Mycobacterium smegmatis;Nitrogen;non-tuberculosis mycobacteria;novel;novel therapeutic intervention;novel therapeutics;Outcome;Oxygen;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phenotype;Physicians;Physiologic tolerance;Physiological;Predisposition;Prevalence;prevent;Process;protein function;Public Health;Regimen;Regulation;Research;Resistance;Ribosomes;Role;sensor;Shapes;Signal Transduction;Sputum;Structure;System;Techniques;Testing;therapeutic development;three-dimensional modeling;Tissues;trait;Translations;treatment choice;Variant;Visualization;Work

PROJECT_TITLE: The Impact of the Cystic Fibrosis infection environment on biofilm development of nontuberculous mycobacteria


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Aging;Arthritis;Back Pain;Brain Disorders;Chronic Pain;Clinical Research;Neurodegenerative;Neurosciences;Osteoarthritis;Pain Research;Peripheral Neuropathy

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Chronic pain is still a clinical diagnosis because no mechanistic quantitative, objective, and reliable measures exist to assist in diagnosis and classification of this condition. Such measures will further our understanding of the pathophysiology of different chronic pain syndromes, help clinicians make informed decisions and improve clinical care, and provide highly needed quantitative measures to be used in clinical trials of novel analgesics. In this proposal, we test whether the brain signature of chronic low-back pain is specific to low-back pain or generalizable to other chronic musculoskeletal conditions like knee arthritis pain or neuropathic chronic pain, or other chronic negative affective conditions like major depressive disorder, and whether this neural signature is modulated by patients’ age or sex.

PI_NAMEs: GEHA, PAUL  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Address;Affect;Affective;Age;age effect;age group;aged;Aging;Agreement;Analgesics;arthritic pain;Arthritis;Back Pain;Biological Markers;Brain;Brain imaging;Brain Pathology;Caring;Chronic;Chronic low back pain;chronic musculoskeletal pain;chronic neuropathic pain;chronic pain;chronic pain patient;Chronic pain syndrome;chronic painful condition;Classification;Clinical;clinical care;clinical diagnosis;Clinical Trials;Corpus striatum structure;cost;Data;Decision Making;design;Diagnosis;Diagnostic;disability;Emotional;executive function;Exhibits;experience;Expert Opinion;Female;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Grouping;improved;inter-individual variation;Knee;Knee Osteoarthritis;knee pain;Laboratories;Learning;Limbic System;Literature;Low Back Pain;Machine Learning;Major Depressive Disorder;male;Measurement;Measures;Medial;Mediating;Medical;Memory;Modeling;Moods;Musculoskeletal;Musculoskeletal Pain;Nature;negative affect;neural;neuroimaging;novel;Nucleus Accumbens;older patient;osteoarthritis pain;Pain;Pain intensity;pain patient;Pain Research;painful neuropathy;Pathology;Patients;Population;pre-clinical;predictive modeling;Prefrontal Cortex;Prognosis;Reporting;Reproducibility;Reproducibility of Results;Sampling;Sensitivity and Specificity;sex;Societies;Specificity;Structure;Substance Use Disorder;Syndrome;Techniques;Testing;Thick;tool;Training;Trigeminal Neuralgia;Work

PROJECT_TITLE: Brain Mechanisms of Chronic Low-Back Pain: Specificity and Effects of Aging and Sex

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Mental Health;Neurosciences;Pain Research

ORG_CITY: BALTIMORE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative Chronic stress is comorbid with a wide spectrum of conditions, such as anxiety, depression, and pain. The mechanisms by which stress exacerbate pain are poorly understood. Here, we study how chronic stress and somatic pain interact within the lateral parabrachial nucleus to augment behavioral responses to pain.

PI_NAMEs: CRAMER, NATHAN P;MASRI, RADI  (contact)

PROJECT_TERMS: Affect;Affective;Amygdaloid structure;Anatomy;Animal Model;Animals;Anxiety;Attenuated;Behavior;behavioral response;Cell Nucleus;Chronic;Chronic stress;Cognitive;comorbidity;dorsal horn;Electrophysiology (science);Emotional;emotional stimulus;Fiber;Fright;Goals;Homeostasis;Hypothalamic structure;In Vitro;in vivo;Interoception;Intervention;Lateral;Learning;Mental Depression;multimodality;Nervous System;Neurons;Nociception;noradrenergic;novel;Nucleus solitarius;optogenetics;Output;Pain;pain signal;parabrachial nucleus;Pathology;Pathway interactions;Pharmacogenetics;Photometry;Play;Positioning Attribute;Presynaptic Terminals;Prosencephalon;Quality of life;respiratory;response;restraint stress;Role;Route;sensor;Sensory;sensory input;Signal Transduction;Sleep disturbances;Spinal;Stimulus;Stress;Structure;Synapses;Testing;Time;transmission process;Trigeminal System;Visceral;Visceral Afferents

PROJECT_TITLE: Interoception and Pain: Noradrenergic Modulation of Nociceptive Transmission in the Parabrachial Nucleus


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Pediatric

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Fear generalization is defined as the overgeneralization of fear from a conditioned, fear-inducing stimulus to novel, neutral stimuli. Fear generalization is a core symptom often observed in anxiety disorders and post- traumatic stress disorder (PTSD). Here, we will first identify the neural ensembles mediating fear generalization in adolescent and adult mice of both sexes and then pharmacologically manipulate these neural ensembles with (R,S)-ketamine as a therapeutic for ameliorating generalized fear behavior.

PI_NAMEs: DENNY, CHRISTINE ANN (contact);MASTRODONATO, ALESSIA

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: 4-Hydroxy-Tamoxifen;Adolescence;Adolescent;Adult;Adult women;Age;age effect;age related changes;Anatomy;Anesthetics;anti-depressive agents;Anxiety Disorders;Applications Grants;Behavior;Behavioral;Behavioral Assay;Biological Assay;Brain;Brain imaging;Brain region;brain tissue;Cells;Childhood;conditioned fear;Cytoskeletal Proteins;Data;dentate gyrus;design;Discrimination;Discrimination Learning;Dose;Environment;Euthanasia;experimental study;Exposure to;Female;Female Adolescents;Freezing;Fright;Genetic;Goals;Hippocampus;Hour;Image;Immediate-Early Genes;Impairment;improved;Individual;Ketamine;Label;Laboratories;life span;Location;male;Male Adolescents;Measures;Mediating;Memory;memory encoding;Mental disorders;Mouse Protein;Mus;National Institute of Mental Health;neural;neural circuit;neural correlate;neural network;Neurons;NMDA receptor antagonist;novel;old mice;Outcome Study;Pattern;pharmacologic;Phenotype;Population;Post-Traumatic Stress Disorders;Prefrontal Cortex;Process;Proteins;Protocols documentation;Publications;Publishing;Reporting;Research Domain Criteria;response;Rest;Retrieval;Saline;sex;Shock;Stimulus;Strategic Planning;Symptoms;System;Testing;Therapeutic;Time;Transgenic Mice

PROJECT_TITLE: Identifying the neural ensembles mediating fear generalization during adolescence

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Vaccine Related

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

PHR: Our goal is to develop therapeutic HIV vaccines to reduce the HIV reservoirs in children and youth with HIV. The knowledge will contribute to the optimization of this strategy and exert sustained influence on HIV cure research for children.

PI_NAMEs: PALMA, PAOLO ;ROBB, MERLIN L (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: adaptive immune response;Adherence;Adjuvant;Adult;Age Months;Agonist;Antibodies;antibody-dependent cell cytotoxicity;Antigens;antiretroviral therapy;Binding;Biological Assay;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cervarix;Child;Childhood;Clinical Trials;cohort;Collaborations;Data;Dendritic Cells;DNA;Enrollment;Failure;Frequencies;Funding;Generations;Goals;Grant;HIV;HIV vaccine;Human Papillomavirus;Immune;Immune response;Immunity;immunogenicity;Immunologic Surveillance;Infant;Intervention;Knowledge;Licensing;Measures;Military Personnel;Mississippi;Modality;neutralizing antibody;novel strategies;open label;Oral;Participant;perinatal HIV;Pharmaceutical Preparations;Phase;Plasma;Population;post intervention;programs;Randomized;randomized, clinical trials;Recommendation;Regimen;Research;RNA;RNA Splicing;Safety;Sampling;sharing platform;South Africa;T cell response;Therapeutic;therapeutic development;therapeutic vaccine;TLR4 gene;Vaccination;vaccine immunogenicity;vaccine strategy;Vaccines;Viral;Viremia;Virus;Youth

PROJECT_TITLE: Targeting HIV reservoirs in children with HIVIS DNA and MVA-CMDR vaccines

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative Mapping polyclonal humoral immune responses to evaluate on and off target antibody responses is a critical component of rational, structure-based vaccine design. To this end we recently developed a methodology to directly image polyclonal immune responses using electron microscopy to map epitopes on immunogens and viral glycoproteins such as HIV. We now plan to increase throughput, improve resolution, and apply to non-IgG immunoglobulins such as IgA.

PI_NAMEs: HANGARTNER, LARS OLIVER;WARD, ANDREW BARRETT (contact)

PROGRAM_OFFICER_NAME: MALASPINA, ANGELA

PROJECT_TERMS: Amino Acids;Antibodies;Antibody Binding Sites;Antibody Response;Antigens;B cell repertoire;B-cell receptor repertoire sequencing;B-Lymphocytes;Bar Codes;Blood Circulation;Cells;Clinical;Clinical Research;Complementarity Determining Regions;Cryoelectron Microscopy;Data;data format;data repository;database query;design;Electron Microscopy;Engineering;Epitope Mapping;Epitopes;Evaluation;Funding;Future;Genes;Germ Lines;Glycoproteins;HIV;HIV vaccine;Human;Image;Immune response;Immunogenetics;Immunoglobulin A;Immunoglobulin Somatic Hypermutation;Immunoglobulins;improved;Knock-in Mouse;Maps;Methodology;Methods;Miniaturization;miniaturize;Molecular;Monoclonal Antibodies;mouse model;Mucous Membrane;Negative Staining;neutralizing antibody;nonhuman primate;pathogen;phase I trial;Polishes;polyclonal antibody;Polysaccharides;pre-clinical;Preparation;Production;Productivity;Property;Publications;Resolution;Sampling;single-cell RNA sequencing;Site;Specificity;Structure;Surface;Technology;Testing;vaccination strategy;Vaccine Design;vaccine development;Vaccines;Viral

PROJECT_TITLE: Dissecting Polyclonal Sera to Reveal Correlates of Productive Immune Responses to HIV


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Understanding human body plan development will shine light on the etiology of congenital diseases and contribute to regenerative medicine. I have established in vitro models of human somite formation using pluripotent stem cells and will construct novel models recapitulating human limb development. Building on my finding that cell sorting underlies somite anteroposterior patterning, I will continue using these models to illuminate mechanisms of pattern formation along the body axis and appendages.

PI_NAMEs: MIAO, YUCHUAN  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: 3-Dimensional;Adopted;Animal Model;Anterior;appendage;Biological;Capsicum;career;Cell Differentiation process;Cell Maturation;Cell Separation;Cells;Complex;Data;Development;Development Plans;Developmental Process;differentiation protocol;Digit structure;Disease;Distal;Embryo;embryo cell;Engineering;Ensure;Epithelium;Ethics;Etiology;experimental study;Foundations;Future;Genes;Genetic;Goals;Human;Human body;Human Development;human model;human pluripotent stem cell;In Vitro;in vitro Model;in vivo;Individual;induced pluripotent stem cell;insight;Investigation;Knowledge;Length;Light;Limb Bud;Limb Development;Limb structure;Link;Literature;Mediating;medical specialties;Mentors;Mesenchymal;Mesoderm Cell;Modeling;Molecular;Morphogenesis;Musculoskeletal Diseases;novel;Organ;Organoids;Paraxial Mesoderm;Pattern;Pattern Formation;Periodicals;Peripheral Nervous System;Phase;Pluripotent Stem Cells;Postdoctoral Fellow;progenitor;Proxy;Regenerative Medicine;Research;Resolution;Role;Segmentation Clock Pathway;self organization;Sodium Chloride;Somites;somitogenesis;spatiotemporal;Specific qualifier value;spine bone structure;stem cells;Structure;Testing;three dimensional cell culture;three-dimensional modeling;Tissues;Training;Work

PROJECT_TITLE: Deconstructing human body plan development with stem cells

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE  One crucial goal of Down syndrome (DS) research is to understand the transition from normal developmental progression to the onset of aging-related cognitive decline, including determining when early indicators of decline emerge. Although language is a critical area of focus in DS, there are no data in DS on the development of many of the spoken language metrics implicated to decline with the progression of Alzheimer’s Disease in the general population. In this project, we propose to extend existing Expressive Language Sampling procedures, which are recommended for investigations of language development in DS, into a much-needed toolbox of psychometrically sound metrics that can be used to elucidate language development across the lifespan, bridging the conceptual gap between assessing development and age-related declines in DS.

PI_NAMEs: THURMAN, ANGELA JOHN (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: 16 year old;20 year old;Address;Adolescent and Young Adult;Adult;Age;age related;age related decline;Age Years;Aging;aging related;Alzheimer's Disease;Alzheimer's disease diagnosis;Amyloid beta-Protein Precursor;Area;autism spectrum disorder;Characteristics;Child;Childhood;Chromosome 21;Chronology;Code;Cognition;Cognitive;cognitive function;cognitive skill;cohort;Communication;Data;Data Set;density;Development;Diffuse;Disease Progression;Down's Syndrome;early onset;efficacy evaluation;emerging adult;follow-up;Fostering;Funding;General Population;Genes;Genetic;Genetic Transcription;Goals;Growth;Head;Heterogeneity;Impaired cognition;improved;Incidence;indexing;Individual;Intellectual functioning disability;Intervention;Investigation;Language;Language Development;lexical;life span;Measurement;Measures;mild cognitive impairment;National Institute of Child Health and Human Development;neuropathology;non-verbal;novel therapeutic intervention;Outcome;Outcome Measure;Participant;Pattern;Performance;Phase;Phenotype;pre-clinical;Prevention strategy;Procedures;promote resilience;Property;Psychometrics;Recommendation;Research;Research Personnel;resilience;Risk;Sampling;secondary analysis;Semantics;Senile Plaques;Severities;sex;Short-Term Memory;skills;sound;standardize measure;symptomatology;Symptoms;syntax;Testing;Time;tool;Transcript;Treatment outcome;Variant;verbal;Youth

PROJECT_TITLE: Development of aging-sensitive spoken language measures in children, adolescents, and young adults with Down Syndrome

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE  Childhood undernutrition is a pervasive, pressing global health challenge whose associated morbidities (immune and metabolic dysfunction, stunting, neurodevelopmental abnormalities) are inadequately treated with current interventions. The contribution of the gut microbiota to pathogenesis is underexplored. This project seeks to understand (i) mechanisms by which a promising microbiota- directed complementary food (MDCF-2) is able to significantly improve the weight gain in children with moderate acute malnutrition, (ii) how biotransformation of its component glycans influences postnatal microbiota and host development and (iii) how to design next-generation MDCFs.

PI_NAMEs: ZHOU, CYRUS  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Acute;Affect;Animals;bacterial community;bacterial fitness;Bangladeshi;Body Composition;Body Weight Changes;bone;Carbohydrates;Child;Childhood;Collection;community transmission;comorbidity;Consumption;conventional therapy;Data;Data Set;density;design;Development;Diagnostic;Diet;Dietary Polysaccharide;DNA;Enzymes;Fatty acid glycerol esters;fecal microbiome;feeding;fitness;Food;Formulation;Genes;Genome;Genomics;Germ-Free;global health;Gnotobiotic;Goals;Growth;gut microbiome;gut microbiota;Health;Height;Human Genome;human study;Immune;Immune System Diseases;Immunologics;Impairment;improved;in silico;In Vitro;in vivo;in vivo evaluation;Infant;Intervention;lean body mass;Length;Life;Linear Models;Link;long-term sequelae;Magnetic Resonance;Malnutrition;Maps;Mass Spectrum Analysis;Measures;Mediator;member;Metabolic;Metabolic Biotransformation;Metabolic dysfunction;Metabolic Pathway;metagenome;metatranscriptome;Microbe;microbial;microbial community;microbiome;microbiota;microbiota transplantation;Monitor;Morbidity - disease rate;Morphology;mortality;Motivation;Mus;Neurologic Deficit;next generation;novel therapeutic intervention;novel therapeutics;Participant;Pathogenesis;Pectins;Phenotype;Plasma Proteins;Play;Polysaccharides;Population;postnatal;postnatal development;preclinical study;predictive modeling;Program Development;Randomized;rate of change;Refractory;repaired;Research;response;Series;Shotgun Sequencing;stool sample;Testing;Therapeutic;therapeutically effective;Transcript;Transplantation;wasting;Weight;Weight Gain;Xylans

PROJECT_TITLE: Mechanism of action of a microbiota-directed complementary food that promotes ponderal growth in Bangladeshi children with moderate acute malnutrition


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Microbiome;Prevention

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative The National Institutes of Health, the World Health Organization and the Center for Disease Control are concerned that the development of antibiotics is lagging behind the rise of drug resistance and the evolution of bacterial pathogens. Knowledge of enzymatic transition states has evolved as an efficient method of drug design. This proposal applies transition state technology to the problem of antibiotic resistance and disruption of the gut microbiome in the potentially lethal colitis caused by Clostridioides difficile. The use of novel transition state analogs against the major toxins from C. difficile will protect the gut, preserve the gut microbiome and avoid the use of antibiotics that cause the development of antibiotic resistance.

PI_NAMEs: SCHRAMM, VERN L. (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Affect;Affinity;analog;Animal Experiments;anti-toxin;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Apoptosis;Bacterial Toxins;Binding;Biological Assay;Catalytic Domain;cdc42 GTP-Binding Protein;Ceftriaxone;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chemicals;Clinical;Clinical Trials;Clostridioides difficile vaccine;Clostridium;Clostridium difficile;Colitis;Complex;computational chemistry;Crystallography;Cytoskeleton;cytotoxicity;design;Development;Disease;Drug Design;Drug resistance;Electrostatics;Environment;Epithelial Cells;Equilibrium;Evolution;Excretory function;Fatal Outcome;FDA approved;fecal transplantation;gastrointestinal epithelium;Glucose;Glucosyltransferase;Glucosyltransferases;glycosylation;glycosyltransferase;GTP-Binding Proteins;Guidelines;gut microbiome;gut microbiota;Health Care Costs;healthcare-associated infections;holotoxins;Hospitals;Human;Hydrolysis;Hypotension;Ileus;Immunity;Infection;Infection prevention;inhibitor;innovation;insight;Isotopes;Kinetics;Knowledge;Lactamase;Lead;Life;Maps;Medical;Megacolon;Methods;microbial;microbiome;Microfilaments;Modeling;Molecular;Monoclonal Antibody Therapy;Morbidity - disease rate;mortality;mouse model;neutralizing antibody;North America;novel;Oral;oral infection;Organism;pathogen;pathogenic bacteria;Pathology;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;phase II trial;Population;preservation;pressure;prevent;Process;Production;programs;Proliferating;Proteins;Pseudomembranous Colitis;quantum chemistry;Reaction;Recommendation;Recovery;recurrent infection;Reporting;Reproduction spores;Resistance;rho;Roentgen Rays;screening;Shock;small molecule;Structure;symptom treatment;Technology;Testing;Thermodynamics;Threonine;Tissues;Toxic effect;Toxin;Transferase;United States National Institutes of Health;Uridine Diphosphate Sugars;Vaccines;Vancomycin;Virulence Factors;World Health Organization

PROJECT_TITLE: Targeting Clostridioides difficile with microbiome-sparing, resistant-proof anti-toxins

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: There is a critical unmet need for imaging tools that accurately risk stratify atherosclerotic patients based on their inflammatory phenotype and identify those where a given therapy is indicated and then monitor its effect. The monocyte chemoattractant protein-1 / C-C chemokine receptor type 2 (MCP-1/CCR2) axis is of particular interest because of its role in atherosclerotic lesion formation and its progression. In this proposal we will perform the initial evaluation of the imaging performance of a PET radiotracer [64Cu]DOTA-ECL1i in humans with peripheral carotid and femoral arterial atherosclerosis and obtain key biological information that is foundational for the design of future studies to assess its capability for diagnosis, prognosis assignment and evaluation of new therapies.

PI_NAMEs: GROPLER, ROBERT J. (contact);WOODARD, PAMELA K;ZAYED, MOHAMED A.

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: American;Anti-Inflammatory Agents;Area;Arterial Fatty Streak;Atherosclerosis;Autoradiography;Binding;Biological;Biological Assay;Bone Marrow;calcification;Cardiovascular Diseases;cardiovascular disorder risk;Carotid Arteries;CCL2 gene;CCR1 gene;Cell Line;Cells;Characteristics;chemokine;chemokine receptor;comorbidity;Copper;cytokine;Data;design;Detection;Diabetes Mellitus;Diagnosis;Disease Management;Disease Progression;Endarterectomy;Evaluation;extracellular;femoral artery;Femur;Fluorescence-Activated Cell Sorting;Foundations;Future;Gene Expression;Hematopoiesis;Hemorrhage;high risk population;Host Defense;Human;human subject;Image;Image Analysis;imaging approach;Imaging Device;imaging study;Immune;Immunohistochemistry;in vivo imaging;Inflammation;Inflammatory;interest;Lesion;Macrophage;Measurement;Mediating;Modeling;Modernization;Molecular;Molecular Profiling;Monitor;monocyte;monocyte chemoattractant protein 1 receptor;mortality;Multicenter Studies;Non-Invasive Detection;novel therapeutics;optimal treatments;Outcome Study;Pathway interactions;patient population;Patients;Peptides;Performance;Peripheral;Peripheral arterial disease;Phenotype;Play;Populations at Risk;Positron-Emission Tomography;pre-clinical;Process;Prognosis;Radiolabeled;radiotracer;receptor;receptor expression;recruit;Reproducibility;Research;Reverse Transcriptase Polymerase Chain Reaction;Risk Factors;risk stratification;Role;Sampling;Seminal;Signal Transduction;Site;Smoking;Spleen;systemic inflammatory response;targeted imaging;Thrombosis;Tissues;trafficking;transcriptomics;treatment response;volunteer

PROJECT_TITLE: PET Detection of CCR2 in Human Atherosclerosis

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: RENO

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: PROJECT NARRATIVE The overarching objective is to elucidate the specificity and mechanism of breast tumor suppression in response to signaling from the CD36+ fibroblasts (FBs). We address a gap that is mostly unexplored by taking advantage of the FBs component of the stroma. This initiative will be supported by rigorous quantitative assays and novel computational methods to assess the response of the tumor microenvironment to secreted factors by CD36+ FBs. The proposed project is relevant to public health because it will justify the use of secreted factors as therapy or preventative agent in breast cancer.

PI_NAMEs: PARVIN, BAHRAM A. (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;3D Print;activin A;Address;Agonist;Animals;Apoptotic;Biochemical;Biochemical Markers;Bioinformatics;Biological Assay;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer therapy;cancer cell;cancer subtypes;cancer therapy;CD36 gene;Cell Death;Cell Line;Cell secretion;Cell Surface Receptors;ChIP-seq;Clinical;Computing Methodologies;Coupling;Data;deep learning;Development;established cell line;Fatty acid glycerol esters;Fibroblasts;genetic signature;genomic signature;Goals;Growth;Heterogeneity;humanized mouse;Image;Immunocompetent;Immunocompromised Host;in vivo Model;Incubated;Induction of Apoptosis;innovation;insight;Ligands;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary gland;Mammary Neoplasms;Microscopy;mitochondrial dysfunction;Modeling;Molecular;Morphology;mouse model;Multi-Drug Resistance;Mus;neoplastic cell;new technology;next generation;novel;novel therapeutics;Organoids;overexpression;Pathway interactions;patient derived xenograft model;Patients;physical property;Pilot Projects;Pre-Clinical Model;Printing;Property;Protein Secretion;Proteins;Proteomics;Public Health;Recombinant Proteins;recruit;Regulatory Element;Resected;response;screening;side effect;Signal Pathway;Signal Transduction;Specificity;System;systemic toxicity;Targeted Research;targeted treatment;Techniques;Technology;technology platform;Testing;Therapeutic;three dimensional cell culture;Time;Toxic effect;transcription factor;transcriptomics;translational impact;Transplantation;treatment response;tumor;tumor growth;tumor microenvironment;Tumor Pathology;Tumor Subtype;Tumor Suppression;Tumor Tissue

PROJECT_TITLE: A novel breast cancer therapy based on secreted protein ligands from CD36+ fibroblasts

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH American Indians/Alaska Natives (AI/AN) have a high prevalence of commercial cigarette smoking and a low rate of cessation. This may be attributed to the rate of nicotine metabolism, which is predominately determined by genetic variation and has informed the type of pharmacological treatment associated with enhanced smoking cessation. This project will set the stage for personalized cessation treatment interventions in AI/AN by examining the rate of nicotine metabolism among AI/AN smokers and perceptions of and barriers to using genetically-informed data to inform cessation treatment among AI/AN smokers and their healthcare providers.

PI_NAMEs: CARROLL, DANA MOWLS (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: African ancestry;Alaska Native;Alaska Native population;Alleles;American Indian Population;American Indians;Appointment;Area;Award;Behavior;Biological Markers;Cancer Center;career development;Chippewa;cigarette smoke;cigarette smoking;Clinical Trials;Collaborations;Communities;Data;Development;Development Plans;Disparity;Dose;Epidemiology;European ancestry;experience;Exposure to;Fellowship;Focus Groups;Foundations;Funding;Genes;Genetic;genetic analysis;genetic approach;Genetic Predisposition to Disease;Genetic Research;Genetic study;Genetic Variation;Genotype;Goals;Grant;Health Personnel;High Prevalence;implementation barriers;improved;Infrastructure;Intervention;Investments;K-Series Research Career Programs;loss of function;Mentorship;Metabolism;Methods;Mille Lacs Band;Minnesota;Molecular Genetics;National Institute of Drug Abuse;Nicotine;Nicotine Dependence;nicotine patch;Perception;personalized approach;personalized medicine;Pharmacological Treatment;Phenotype;phenotypic biomarker;phenotypic data;Population;Postdoctoral Fellow;professor;programs;Provider;Public Health;Public Health Schools;Qualitative Research;Race;racial minority;Recommendation;Recording of previous events;Research;Research Methodology;Research Personnel;Research Proposals;Residual state;Resources;response;rural area;Scientist;side effect;skills;Smoke;Smoker;Smoking;Smoking Behavior;smoking cessation;Smoking Cessation Intervention;smoking prevalence;social;social culture;sociocultural determinant;Statistical Data Interpretation;success;System;Tobacco;Tobacco Dependence;tobacco exposure;Tobacco use;Training;Treatment Efficacy;treatment research;tribal community;Tribes;Trust;undergraduate student;United States National Institutes of Health;Universities;varenicline;Withholding Treatment

PROJECT_TITLE: Laying the Foundation for Personalized Smoking Cessation Treatment in the American Indian Population


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Infertility;Maternal Health;Pediatric;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Relevance to Public Health: Defect in trophoblast lineage development results in early pregnancy loss or leads to pregnancies that are associated with intrauterine growth restriction or preeclampsia, which are leading causes of maternal death and premature birth. These are major public health concerns. Therefore, a better understanding of trophoblast cell lineage development and function is critical to gain insights into important features of pregnancy loss and pregnancy associated disorders.

PI_NAMEs: PAUL, SOUMEN  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Affect;blastocyst;Blood Vessels;Cell Lineage;Cells;Chorion;Conceptus;conditional knockout;Cone;cytotrophoblast;Defect;Development;Disease;early pregnancy loss;Ectoderm;Embryo;Ensure;Fetal Growth Retardation;First Pregnancy Trimester;Gases;gene conservation;Gene Expression;Gene Expression Regulation;Genetic Transcription;Goals;Hormone secretion;Human;Impairment;implantation;insight;Knockout Mice;Laboratories;Maintenance;Maternal Mortality;Maternal-Fetal Exchange;Mediating;Molecular;Mothers;mouse model;Mus;mutant mouse model;natural Blastocyst Implantation;Nutrient;Patient Recruitments;Patients;Placenta;Placentation;Population;Pre-Eclampsia;Pregnancy;pregnancy failure;Pregnancy loss;Premature Birth;Primordium;Process;progenitor;programs;Public Health;Publishing;Recording of previous events;Recurrence;Reproduction;Research;self-renewal;Signal Transduction;Specific qualifier value;stem;stem cell self renewal;stem cells;Testing;transcription factor;trophoblast;trophoblast stem cell

PROJECT_TITLE: Hippo Signaling Effector and Placentation


ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The goal of this project is to investigate if the early stage osteoarthritis (OA) affects the mechanical properties of knee joint tissues in an MRI detectable manner prior to morphological alterations. We will perform knee joint evaluation under mechanical loading that mimics our standing position, using novel quantitative MRI techniques that are insensitive to tissue orientation in the MRI scanner. After accelerating our techniques (UTE-MRI), we will determine if the variation pattern of UTE-MRI under loading is distinct for early stage OA patients, and if bone structure for early stage and mild OA knees improves to support the defected knee regions in a detectable manner by MRI and CT.

PI_NAMEs: JERBAN, SAEED  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Age;Anatomy;Body mass index;Body Weight;bone;Bone structure;Cadaver;career development;Cartilage;Chemicals;Clinical;clinical imaging;Cone;Defect;Degenerative polyarthritis;design;Development Plans;Devices;Diagnosis;Early Diagnosis;Evaluation;experience;Fiber;Gender;Goals;hamstring;Human;Image;Imaging Techniques;improved;in vivo;Joints;Knee;Knee joint;Knee Osteoarthritis;Magic;Magnetic Resonance Imaging;Manuals;Measurement;Measures;mechanical load;mechanical properties;Mechanical Stress;Mechanics;Meniscus structure of joint;Mentored Research Scientist Development Award;Mentors;Mentorship;Modeling;Morphology;multidisciplinary;novel;Pain;Patients;Pattern;Phase;Physiological;Positioning Attribute;Postdoctoral Fellow;Preparation;Process;Property;quadriceps muscle;Radiology Specialty;reconstruction;Research;Research Personnel;research study;Rest;Scanning;Signal Transduction;Specimen;Stretching;Structure;substantia spongiosa;Supine Position;Techniques;Time;Tissues;Training;United States National Institutes of Health;Variant;ward

PROJECT_TITLE: Knee evaluation under mechanical loading by cones ultrashort echo time MR imaging

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Cancer cells are protected by surrounding fibrotic stromal barrier supporting the cancer growth, suppressing the immune response, and preventing the delivery of therapeutic molecules. Our team has identified first-in-class orally bioavailable small molecule activators of relaxin receptor which demonstrate anti-fibrotic and anti- inflammatory effects. We plan to demonstrate that our lead compound may improve the therapeutic efficacy of known anticancer drugs in several preclinical mouse models of breast cancer.

PI_NAMEs: AGOULNIK, ALEXANDER I;AGOULNIK, IRINA  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: 4T1;Affect;Agonist;Allografting;American;Animal Model;Animals;anti-cancer;anti-cancer treatment;anti-PD-L1;Antibodies;Antibody Therapy;anticancer activity;Antiinflammatory Effect;Antineoplastic Agents;Biological Availability;Breast Cancer Model;Breast Cancer therapy;Breast Cancer Treatment;cancer cell;Cancer Cell Growth;cancer invasiveness;Cancer Model;Cancer Patient;cancer subtypes;cell killing;Cell Proliferation;Cell Survival;Cells;Characteristics;Chronic;Collagen;Combined Modality Therapy;Continuous Infusion;Cytoprotection;Cytotoxic T-Lymphocytes;Data;Development;Diagnosis;disease model;Dose;Drug Kinetics;Drug resistance;Drug Targeting;Drug usage;Elastin;Environment;ERBB2 gene;Excision;experimental study;Extracellular Matrix;Fibroblasts;Fibronectins;Fibrosis;G-Protein-Coupled Receptors;Genomics;Goals;Growth;Half-Life;Hormones;Immune;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune response;Immunocompetent;immunogenic;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Inbred BALB C Mice;Inflammatory;Laboratories;Laboratory Research;Lead;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Metastatic breast cancer;Modification;molecular subtypes;Monoclonal Antibodies;mouse model;Mus;Neoplasm Metastasis;novel therapeutic intervention;novel therapeutics;Oral;Pathway interactions;Patients;Penetration;peptide hormone;Peptides;Phagocytosis;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacotherapy;Population;pre-clinical;Pre-Clinical Model;prevent;Primary Neoplasm;programmed cell death ligand 1;Property;Proteomics;Recombinants;recruit;Relaxin;relaxin receptor;Reporting;Resolution;response;Route;side effect;Signal Transduction;small molecule;Solid;Stimulus;Stromal Cells;Stromal Neoplasm;T cell infiltration;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Tissues;Toxic effect;Transgenic Mice;Transgenic Model;Translating;Treatment Efficacy;tumor;tumor growth;tumor microenvironment;tumor-immune system interactions;Woman

PROJECT_TITLE: Targeting breast cancer microenvironment with small molecule agonist of relaxin receptor


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Juvenile hormone plays a critical role in mosquito egg maturation; its synthetic mimics have shown promise to effectively sterilize adult female mosquitoes. The goal of this project is to elucidate the molecular actions of juvenile hormone and its mimics in mosquitoes and to identify new potential target sites in the juvenile hormone signaling pathway for pesticide development.

PI_NAMEs: ZHU, JINSONG  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Adult;Adult women;Aedes;Affinity;Alternative Splicing;Binding;Biological Assay;Biology;Blood;Calcium;Cell membrane;Cell Nucleus;Cells;Chemicals;Chromatin;Communicable Diseases;Complex;Culicidae;Cultured Cells;Dengue Fever;Development;Dimensions;dimer;disease transmission;DNA Binding;ecdysteroid receptor;Ecdysterone;Effectiveness;egg;Endocrine;Epidermal Growth Factor Receptor;ERG gene;Evolution;Exhibits;Fat Body;Female;Fertility;Funding;Gene Expression;Genes;Genetic Transcription;Genomics;Global Change;Goals;Homologous Gene;hormonal signals;Hormone Receptor;improved;Insecticide Resistance;Insecticides;Juvenile Hormones;knock-down;Knock-out;Knowledge;Light;Malaria;Measures;Mediating;Membrane;Methoprene;Molecular;Mosquito Control;mosquito reproduction;Mosquito-borne infectious disease;non-genomic;Nuclear;Pathway interactions;Pattern;Pesticides;Play;Population;prevent;promoter;protein aminoacid sequence;Proteins;pyrethroid;receptor;Receptor Protein-Tyrosine Kinases;Regulation;Reporting;Repression;Reproduction;Resistance;response;RNA Interference;Role;screening;Signal Pathway;Site;Specificity;structural determinants;Testing;Time;Tissues;tool;Toxic effect;transcription factor;transcriptome sequencing;transcriptomics;transmission process;vector control;vector mosquito;Zika Virus

PROJECT_TITLE: Molecular mechanism of juvenile hormone action in mosquito reproduction

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Estrogen;Genetics;Immunotherapy;Inflammatory Bowel Disease

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Steroid sex hormones such as 17β-estradiol (estrogen) are important regulators of immune responses. Although estrogen is generally immunoprotective, our data show that it contributes to the pathogenesis of chronic inflammatory diseases such as IBD by impairing the differentiation and function of regulatory T cells (Tregs). This project seeks to identify the mechanism(s) by which altered estrogen signaling impairs Treg- mediated immunosuppression in the chronically inflamed intestine, with the ultimate goal of developing novel approaches for the treatment of IBD.

PI_NAMEs: GOODMAN, WENDY ANN (contact)

PROGRAM_OFFICER_NAME: PERRIN, PETER J

PROJECT_TERMS: Address;Adoptive Transfer;Antigens;Area;Backcrossings;Biological Assay;Biological Response Modifiers;Biopsy;Candidate Disease Gene;CD4 Positive T Lymphocytes;Cell Physiology;Cell Separation;Cells;chromatin immunoprecipitation;Chronic;chronic inflammatory disease;Co-Immunoprecipitations;Colitis;Complex;Crohn's disease;Data;Defect;Disease;Environment;Environmental Risk Factor;Equilibrium;ESR1 gene;Estradiol;Estrogen Receptor 2;Estrogens;Event;Exhibits;experimental study;Female;FOXP3 gene;Frequencies;Gene Expression Regulation;Genetic;Genetic Transcription;Goals;Gonadal Steroid Hormones;gut inflammation;Homeostasis;Human;Ileitis;Immune;Immune response;Immune Tolerance;immunoregulation;Immunosuppression;Impairment;improved;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Intestinal Mucosa;Intestines;Knockout Mice;Knowledge;loss of function;Mediating;Membrane;microbial;Modeling;Molecular;murine colitis;Mus;novel;novel strategies;Nuclear Receptors;Pathogenesis;Pathway interactions;Patients;Peripheral;Phenotype;Predisposition;prevent;Publishing;receptor;Regulatory T-Lymphocyte;Resistance;response;Role;SAMP mouse;Sampling;Sequence Homology;sex;Signal Transduction;T cell differentiation;T cell response;T-Lymphocyte;Technology;Testing;Tissues;transcriptional reprogramming;transcriptome sequencing;Transfection;Transforming Growth Factor beta;Ulcerative Colitis;Western Blotting;Work

PROJECT_TITLE: Estrogen-mediated immune regulation in human and experimental inflammatory bowel disease

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


NIH_SPENDING_CATS: Digestive Diseases;Pediatric

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Massachusetts General Hospital for Children (MGHfC) Digestive Disease Summer Research Program is an NIH-NIDDK-funded educational program that was established in 2015 to engage early-career students in projects that explore various aspects of digestive disease and encourage these students to consider a career in the biomedical sciences. Undergraduate and medical students participate in a 10-week didactic program each summer that includes mentored supervision of independent research, faculty lectures, peer-to-peer scientific presentation / discussion, and career development activities. Providing an independent mentor- supervised research experience for students at an early stage is known to be effective at fostering a strong interest and appreciation for biomedical research and significantly increases the likelihood that a student will pursue future research opportunities and eventually enter the biomedical research workforce.

PI_NAMEs: HURLEY, BRYAN P (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Active Learning;Allergens;Awareness;Biology;Biomedical Computing;Biomedical Engineering;Biomedical Research;career;Career Choice;career development;cohort;Collaborations;Communities;Community Hospitals;Computational Science;design;Development;Digestive System Disorders;Disease;Education;Engineering;Environment;experience;Faculty;Fostering;Funding;Future;gastrointestinal;gastrointestinal system;Gastrointestinal tract structure;General Hospitals;Goals;Health;Hospitals;Immune response;Immunity;Immunology;Individual;Inflammatory Response;interest;Laboratories;Laboratory Research;lectures;Massachusetts;Medical Students;Medicine;member;Mentors;Mentorship;Microbe;microbiome;Mind;Mission;model organism;Mucous Membrane;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Participant;pathogen;Pathology;Patients;Pediatric Hospitals;peer;Persons;Principal Investigator;programs;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Research Training;Rewards;Role;Science;Scientist;skills;Structure;student participation;student training;Students;success;summer program;summer research;Supervision;Surface;symposium;Talents;Teaching Hospitals;Techniques;Time;Training;training opportunity;Training Programs;trend;undergraduate student;Underrepresented Students;United States;United States National Institutes of Health

PROJECT_TITLE: MGHfC Digestive Disease Summer Research Program

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Newark

ORG_DEPT: BIOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Mitochondria are dynamic organelles that actively change their shape to accommodate cellular requirements. Cancer cells can exploit this adaptation to support their energy demands or resist to drug-induced cell death. This proposal aims to 1) determine the precise molecular mechanisms cancer cells alter their mitochondrial morphology during acquisition of drug-resistance and 2) evaluate the therapeutic potential of combining small molecules targeting mitochondrial structure with cell death-inducing agents in acute myeloid leukemia.

PI_NAMEs: GLYTSOU, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Ablation;acquired drug resistance;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Apoptosis;Apoptotic;Architecture;BCL1 Oncogene;Biochemical;Bioinformatics;Blood;cancer cell;career development;Caspase;Cell Death Induction;Cell Line;Cells;chaperonin;Clinical;Collaborations;Combined Modality Therapy;Complex Analysis;course development;CRISPR interference;CRISPR screen;CRISPR/Cas technology;Crista ampullaris;cytochrome c;Data;Development Plans;Drug resistance;drug resistance development;efficacy evaluation;Electron Microscopy;electron tomography;Ensure;Equipment;Event;experimental study;Genes;Genetic;genome-wide;Goals;Growth;Hematopoietic Neoplasms;Hematopoietic stem cells;Homeostasis;Human;In Vitro;in vivo;Induction of Apoptosis;inhibitor;innovation;Laboratories;Lead;leukemia;Malignant Neoplasms;Mediating;Mentors;Microscopy;mimetics;Mitochondria;mitochondrial dysfunction;Molecular;Morphology;mortality;mouse model;novel;OPA1 gene;Organelles;Pathogenesis;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Pharmaceutical Preparations;pharmacologic;Phase;Physiological;post-doctoral training;pre-clinical;prevent;Process;Prognosis;programs;protein complex;Proteins;Proteolysis;Proteolytic Processing;Regulation;Research;research and development;Research Personnel;Resistance;Resistance development;Resources;response;Role;Sampling;Scientist;Shapes;skills;small molecule;spatiotemporal;Stress;Structure;success;superresolution imaging;superresolution microscopy;Survival Rate;System;targeted treatment;Techniques;Testing;Therapeutic;Training;treatment strategy;tumor;United States Food and Drug Administration;Xenograft procedure

PROJECT_TITLE: Targeting mitochondrial dynamics in drug-resistant acute myeloid leukemia

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Hearing Loss;Neurodegenerative;Neurosciences;Rehabilitation

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Age-related hearing loss impacts a large share of the population and can have debilitating consequences with respect to productivity, social isolation, and mental health. A chief complaint of older listeners is poor speech understanding in noise, and the goal of this research is to use sophisticated behavioral and electrophysiological methods to discover the relationships between spatial hearing deficits, auditory streaming, individual variability, and hearing aid directional processing that can lead to enhanced and more precise treatment options.

PI_NAMEs: OZMERAL, EROL JAMES (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Address;Affect;Age;age effect;age related;age related decline;Aging;aging population;Algorithms;Area;Auditory;Auditory system;Behavioral;Bilateral;Binaural;Brain;Communication;Communication difficulty;Complex;cost;Cost Analysis;Costs and Benefits;Cues;Devices;Ear;Electrophysiology (science);Environment;experimental study;Face;Goals;Healthcare;Hearing;Hearing Aids;hearing impairment;Impaired cognition;improved;Individual;Individual Differences;individual variation;innovation;instrument;Intervention;Measures;Mental Health;Methods;microphone;Modeling;Nature;neural;neural circuit;neural patterning;neuromechanism;Noise;normal hearing;novel;novel strategies;Outcome;Pain;Perception;Performance;Play;Population;Positioning Attribute;Presbycusis;Probability;Process;Productivity;Psychophysics;Research;Resolution;response;Role;segregation;Series;Social isolation;sound;Source;Speech;speech in noise;Stimulus;Stream;Technology;Testing;tool;Translating

PROJECT_TITLE: Functional spatial segregation in auditory scene analysis

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


PHR: Project Narrative The proposed research is relevant to public health because it will characterize a novel form of proteostasis. By describing how the response to intracellular pathogens improves tolerance of heat shock, we may find new ways to manage and treat aging-related diseases associated with disruptions in proteostasis. Thus, the proposed research is relevant to the NIH's mission to seek fundamental knowledge about living systems in order to reduce the burden of disease.

PI_NAMEs: TROEMEL, EMILY R (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Affect;aging related;aging related disease;Autophagocytosis;Binding Proteins;Biochemical;biological adaptation to stress;burden of illness;Caenorhabditis elegans;candidate identification;Chronic;Co-Immunoprecipitations;Complex;Cullin Proteins;Cysteine;Data;dimer;Dimerization;Disease;disulfide bond;Disulfides;Enzymes;F-Box Proteins;Genes;Genetic;genetic analysis;Goals;Grant;Health;Heat Stress;Heat-Shock Response;Heterodimerization;Homo;improved;In Vitro;in vivo;Infection;innovation;Intestines;Knowledge;life span;Ligase;Lysosomes;Mass Spectrum Analysis;Mediating;Microsporidia;Mission;mRNA Expression;multicatalytic endopeptidase complex;Multienzyme Complexes;mutant;Names;Nematoda;novel;novel strategies;Organism;Outcome;Oxidation-Reduction;pathogen;Pathway interactions;pharmacologic;polyglutamine;protein aggregation;protein protein interaction;Proteins;Proteomics;proteostasis;proteotoxicity;Public Health;Publishing;Recombinant Proteins;Reporting;Research;response;RNA Viruses;Role;screening;Stress;stressor;Structure;Tertiary Protein Structure;Testing;Tissues;transcriptomics;Ubiquitin;Ubiquitin C;ubiquitin ligase;ubiquitin-protein ligase;United States National Institutes of Health;Up-Regulation;Western Blotting;Work;yeast two hybrid system;Yeasts

PROJECT_TITLE: Probing organismal proteostasis through the response to intracellular infection


ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative Despite the rapid adoption of electronic cigarettes (e-cigs), particularly among the youth, the short- and long- term health effects remain unknown due, in part, to a lack of an e-cig specific biomarker of exposure. The proposed study will utilize the unique structures of the free radicals generated in e-cig aerosols by common e- liquid solvents, propylene glycol and glycerin, to develop a universal, e-cig specific, biomarker of exposure. The results of this study will provide a valuable tool for researchers and regulators in evaluating e-cig exposure and the short- and long-term effects associated with their use.

PI_NAMEs: BITZER, ZACHARY T (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Address;adduct;Adoption;Aerosols;Animals;Antibodies;Area;assault;Award;Biological;Biological Markers;biomarker development;C57BL/6 Mouse;Characteristics;Chemicals;Chronic Obstructive Pulmonary Disease;Data;Detection;Development;Disease;DNA Adducts;e-cigarette aerosols;Electron Spin Resonance Spectroscopy;Electronic cigarette;electronic cigarette use;electronic liquid;Ensure;environmental tobacco smoke exposure;experience;Exposure to;Free Radicals;Freezing;Glycerol;Harm Reduction;Health;in vivo;Inflammation;insight;Long-Term Effects;Lung;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mentorship;metabolomics;Modeling;Mus;Nose;novel;Oxidants;oxidative damage;Oxides;Pathway interactions;Phase;Physiologic pulse;Proliferating;Propylene Glycols;Proteins;pyrroline;Reaction;Research;Research Personnel;Rodent;Rodent Model;Safety;Science;Series;Serum;Solvents;specific biomarkers;Spin Trapping;Structure;symposium;Techniques;Time;Tissues;Tobacco;tobacco regulatory science;Tobacco smoke;tool;toxicant;Training;Translational Research;tumor progression;vaping;Work;Youth

PROJECT_TITLE: Identification of Free Radical Induced Biomarkers of Exposure to Electronic Cigarette Aerosol


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Telehealth

ORG_CITY: AKRON

ORG_NAME: IRX REMINDER, LLC

PHR: A key study reported that TDD rates among newly treated elderly ranged from 7.2% for those taking Risperidone to 11.1% for those taking olanzapine after 2 years of treatment. Earlier meta-analyses estimate TDD frequency in women to be 26.6% and in men 21.6%. Ethnically Chinese and Malaysian mental health patients were studied in Singapore and patients taking anti-psychotic medications were found to have TDD in 40% and 29% of cases respectively. Regardless of prevalence, TDD is a threat to patient adherence and quality of life. TDD only remits in a minority of cases and can be permanent. With 50 million prescriptions for anti-psychotics written annually, more than 44 million persons living with a chronic mental illness are at risk of developing TDD. There are likely over 1.65 million patients living with TDD and the number of patients with TDD is expected to grow with the aging population and increasing off-label use of antipsychotics. This trend is likely accelerated with the increased isolation of existing patients and the increased need for psychiatric treatment due to the pandemic.

PI_NAMEs: STERNS, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Acceleration;Acute;Adherence;Affect;aging population;Algorithms;Anti-emetics;Antipsychotic Agents;Awareness;Behavioral Sciences;Blinking;Brain;Caring;Cellular Phone;Certification;Characteristics;Chinese;Chronic;chronic care model;Clinical;clinical trial participant;Cognitive Science;collaborative care;Collection;commercialization;Computer software;cost;Creativeness;Data;Data Analyses;Data Collection;Detection;detection platform;Development;Diagnosis;Diagnostic;Disabilities experience;Discrimination;Disease remission;Distress;Dopamine Receptor;Early Diagnosis;Elderly;Electronics;Elements;Ensure;Ethnic Origin;experience;Exposure to;Eye;Face;Family;FDA approved;feasibility testing;Female;field study;Frequencies;Funding;Generations;Goals;Health;Health Insurance Portability and Accountability Act;Health Personnel;Health Professional;Human;Human Resources;Impaired cognition;Impairment;improved;Incidence;Individual;Industry;Instruction;interest;Intervention;Interview;Involuntary Movements;Laboratories;Lifelong disability;Limb structure;Link;Lip structure;Machine Learning;Malaysian;male;Marketing;Masks;Medical Care Team;medication compliance;men;Mental Health;Meta-Analysis;Methods;Metoclopramide;mHealth;Minority;Monitor;monitoring device;Movement;Mydriasis;Neurologic;new technology;off-label use;olanzapine;Oral cavity;pandemic disease;Participant;Patient Care;Patient Compliance;Patient Monitoring;Patient observation;patient population;Patient Self-Report;Patient-Focused Outcomes;Patients;Pattern;Persons;Pharmaceutical Preparations;Phase;power analysis;Prevalence;Prevention;Process;Psychiatric therapeutic procedure;Psychiatrist;Qualifying;Quality of life;Race;Records;recruit;remote monitoring;Reporting;Research;Research Personnel;Risk;Risperidone;Sampling;Secure;Self Administration;Self Management;severe mental illness;side effect;Singapore;smartphone application;social stigma;software development;Software Tools;Source;Speech;success;supervised learning;Symptoms;Syndrome;System;Systems Analysis;Tablets;Tardive Dyskinesia;Technology;Technology Assessment;Telemedicine;telepsychiatry;Testing;Time;Tongue;tool;Training;treatment response;Tremor;trend;United States National Institutes of Health;Video Recording;Visit;Voice;Woman;Work;Writing

PROJECT_TITLE: Remote Monitoring and Detecting of Tardive Dyskinesia for Improving Patient Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-SCIL-D(16)]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Human Genome;Lupus;Prevention

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: NARRATIVE In this application, we propose to perform comprehensive functional assessment of an intergenic risk locus for systemic lupus erythematosus on chromosome 12q12. We hypothesize that this locus modulates neighboring long non-coding RNAs and protein-coding genes, resulting with alterations in multiple biological pathways relevant to lupus. This locus presents an ideal model to study how intergenic risk variants contribute to autoimmune disease pathogenesis.

PI_NAMEs: DEMIRCI, F. YESIM ;NIEWOLD, TIMOTHY B (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Alleles;ATAC-seq;Autoimmune Diseases;B-Lymphocytes;Binding;Binding Proteins;Biological;Biological Assay;candidate identification;Cell Line;Cell surface;cell type;Cells;Chromatin;Chromosomes;Code;Complex;Computing Methodologies;CRISPR/Cas technology;cytokine;Data;Data Set;Disease;disorder risk;Electrophoretic Mobility Shift Assay;Elements;Enhancers;Experimental Designs;experimental study;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;genetic variant;Genome;genome editing;genome wide association study;Heritability;Human;Human Cell Line;Immune;Immune system;immunopathology;in silico;Individual;ineffective therapies;Interferon alpha;Interferon Type I;knock-down;Knock-out;Knowledge;Lead;Lupus;Macrophage;Measures;Mediating;Memory B-Lymphocyte;Messenger RNA;Methods;Modeling;monocyte;Morbidity - disease rate;mortality;mRNA Expression;new therapeutic target;novel;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pattern;Phenotype;Plasmids;Production;Proteins;Regulatory Element;Reporter;Reporting;Risk;risk variant;RNA analysis;Role;Site;Small Interfering RNA;System;Systemic Lupus Erythematosus;Testing;TLR7 gene;transcription factor;transcriptome sequencing;Transfection;Untranslated RNA;Variant;Viral Genes

PROJECT_TITLE: Functional consequences of intergenic autoimmune disease risk variants

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Telehealth;Violence Research;Youth Violence

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE This project will develop and evaluate an app-based digital mental health intervention (DMHI) for young adults with repeated NSSI, who are not currently engaged in traditional psychological treatment. We will employ user- centered design methods to understand young adults’ specific needs and preferences, which will then guide the development of a scalable, low-intensity DMHI for this population. Our aim is to develop an app that can provide resources (e.g., psychoeducation and skills) to a large numbers of young people with NSSI who are currently unable or uninterested in accessing traditional psychological treatments.

PI_NAMEs: KRUZAN, KAYLEE PAYNE (contact);MOHR, DAVID CURTIS

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: Address;Adherence;Adolescent;Affect;Age;age group;Anxiety;arm;Attitude;Behavior;behavior change;Behavioral;Borderline Personality Disorder;chatbot;Cicatrix;Cognitive;Collaborations;Collection;Coping Skills;cost;cost effective;Data;demographics;design;Development;digital mental health;Disclosure;Distress;Ecological momentary assessment;Education;Effectiveness;Effectiveness of Interventions;effectiveness validation;emotion regulation;Emotional;Ethnic Origin;evidence base;feasibility trial;Feeling suicidal;follow-up;Frequencies;Fright;Future;Gender;Goals;high risk;Hospitalization;Human;Impairment;improved;Individual;interest;Intervention;Investigational Therapies;Life;lifetime risk;Lived experience;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methods;Motivation;non-suicidal self injury;older adult;Outcome;Outcome Assessment;Participant;patient engagement;Performance;Persons;Population;Population Intervention;preference;Prevalence;primary outcome;Procedures;programs;psychiatric comorbidity;psychoeducation;psychologic;Race;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Regulation;Reporting;Research;Resources;Risk;Role;secondary outcome;Self Efficacy;Self-Injurious Behavior;Services;Severities;skills;skills training;Social isolation;social stigma;suicidal;suicidal risk;Suicide;Suicide prevention;Symptoms;therapy design;Time;Tissues;Trauma;usability;user centered design;Waiting Lists;Work;Workplace;young adult

PROJECT_TITLE: Digital Mental Health Intervention for Nonsuicidal Self-Injury in Young Adults


NIH_SPENDING_CATS: Aging

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PI_NAMEs: KIRKLAND, JAMES L. (contact)

PROJECT_TERMS: adipocyte differentiation;age effect;base;Cells;chemokine;cytokine;Disease;Methods;MicroRNAs;Signal Transduction;Untranslated RNA

PROJECT_TITLE: Effect of Aging on Preadipocyte Differentiation