NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Dementia;Nanotechnology;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE  Perioperative neurocognitive disorders (PND) – including postoperative delirium, delayed neurocognitive recovery, and postoperative neurocognitive disorders – are associated with increased morbidity and mortality, high costs of medical care, and Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD). However, blood biomarkers and pathogenesis of PND remain largely to be determined. The proposed research will use a newly developed and innovative nanoneedle technology to establish a system which could identify blood phosphorylated tau (e.g., Tau-PT217 and Tau-PT181) as biomarkers and pathogenesis of PND, consistent with the mission of NIH/NIA to prevent AD/ADRD by delaying the onset and slowing the progression of AD/ADRD.

PI_NAMEs: ZHANG, YIYING  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: 3-Dimensional;Address;Alzheimer's Disease;Alzheimer's disease related dementia;Anesthesia procedures;Biological Markers;Blood;Blood specimen;C-reactive protein;care costs;Clinical Research;confusion assessment method;cost;Data;Detection;Development;Diagnosis;early detection biomarkers;Eligibility Determination;Enhancers;Enzyme-Linked Immunosorbent Assay;Future;General Anesthesia;high risk;Incidence;Inflammation;innovation;Interleukin-6;Intervention;intervention effect;Knowledge;Measures;Medical Care Costs;Methods;Mission;Modeling;Morbidity - disease rate;mortality;nanoneedle;Neurocognitive;neurocognitive disorder;Neuropsychological Tests;novel;older adult;older patient;Operative Surgical Procedures;Outcome;Participant;Pathogenesis;Patient Recruitments;Patients;Perioperative;Plasma;postoperative delirium;Postoperative Period;prevent;primary outcome;Prospective, cohort study;Proteins;Protocols documentation;Recovery;recruit;Research;retention rate;Risk;Safety;Sampling;Severities;specific biomarkers;System;tau-1;Technology;Testing;Threonine;Time;United States National Institutes of Health

PROJECT_TITLE: Phosphorylated Tau as Biomarkers of Perioperative Neurocognitive Disorder in Older Adults

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_STATE: MA

PHR: Cancer stem cells drive continued tumor growth and are likely less responsive to therapy, retained in tumors to cause relapse, and may be responsible for metastatic spread in a subset of cancers. Here, we will identify heterogeneous cell populations that drive these processes in fusion-negative pediatric rhabdomyosarcoma muscle cancer. Our work will also uncover new mechanisms and therapeutic targets that govern rhabdomyosarcoma cancer stem cell self-renewal, cell state changes, and metastasis.

PI_NAMEs: LANGENAU, DAVID MICHAEL (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Adult;Antibodies;Applications Grants;Automobile Driving;Bar Codes;Biological;cancer stem cell;CD44 gene;Cell Differentiation process;Cell division;cell killing;Cell Line;Cell Lineage;cell type;Cells;cellular imaging;Cessation of life;chemotherapy;Childhood Rhabdomyosarcoma;Childhood Soft Tissue Sarcoma;Classification;Combined Modality Therapy;design;Development;Diagnosis;Differentiation Therapy;Disease;DNA-Binding Proteins;effective therapy;Engraftment;epithelial to mesenchymal transition;experimental study;forkhead protein;FOXO1A gene;Gene Fusion;gene network;Genes;Goals;Growth;Heterogeneity;Human;Human Development;Image;immunodeficiency;in vivo;Longitudinal Studies;malignant muscle neoplasm;Malignant Neoplasms;Mesenchymal;Mesenchyme;Molecular;multiple omics;Mus;Muscle;Muscle Cells;Mutation;myocyte-specific enhancer-binding-factor 2C;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Nonmetastatic;NOTCH3 gene;novel;Oncogenic;Operative Surgical Procedures;Optics;osteogenic;Outcome;Pathway interactions;patient derived xenograft model;Patients;PAX3 gene;PAX7 gene;Pharmacotherapy;Population;potential biomarker;Process;progenitor;programs;Radiation;Radiation therapy;Recording of previous events;Refractory;Regimen;Relapse;Reporter;Reporting;Resistance;Resolution;Rhabdomyosarcoma;Role;self-renewal;single cell sequencing;single-cell RNA sequencing;Skeletal Muscle;stem cell fate;stem cell model;stem cell self renewal;stem cells;Survival Rate;Testing;therapeutic target;Time;time use;tool;transcription factor;translational impact;tumor;tumor growth;tumor heterogeneity;United States;Work;Xenograft procedure;Zebrafish

PROJECT_TITLE: Oncogenic Drivers of Rhabdomyosarcoma Cell State, Cancer Stem Cells and Metastasis

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

ORG_STATE: NY

PHR: PROJECT NARRATIVE Cellular sphingolipid metabolism and their metabolic enzymes are significantly altered in metastatic diseases. The sphingolipid enzyme ceramide kinase (CERK) is prominently associated with cancer. The proposed study will test the hypothesis that nuclear bioactive lipid ceramide-1-phosphate (C1P) and synthesizing enzyme CERK play a critical role in aggressive breast cancers. The knowledge gain ed from this study will be critical for the development of new therapeutics against metastatic diseases.

PI_NAMEs: HAIT, NITAI  (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: 3-Dimensional;aggressive breast cancer;Applications Grants;Attention;Biological Markers;bone;Brain;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;breast cancer progression;Breast Epithelial Cells;cancer cell;Cell Nucleus;Cell surface;Cell Survival;ceramide 1-phosphate;ceramide kinase;Cessation of life;chemotherapy;Clinical;clinically significant;cohort;CRISPR/Cas technology;Data;Development;Disease;Disease Progression;Distant Metastasis;DNA Sequence Alteration;Environmental Risk Factor;Enzymes;Epidermal Growth Factor Receptor;ERBB2 gene;extracellular;FRAP1 gene;Freezing;Funding Mechanisms;Future;G-Protein-Coupled Receptors;genetic approach;Genetic Transcription;Goals;Golgi Apparatus;Growth;Inflammation;Inflammation Mediators;kinase inhibitor;Knowledge;Link;lipid metabolism;Lipids;Liver;Lung;Lung Adenocarcinoma;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammary Neoplasms;Mediating;Messenger RNA;Metabolic;Metabolism;Metastatic Neoplasm to the Bone;migration;Modeling;mouse model;Neoplasm Metastasis;novel;novel therapeutics;Nuclear;Organoids;Outcome;overexpression;Patients;pharmacologic;PI3K/AKT;Play;power analysis;predictive marker;Primary Neoplasm;progression marker;protein expression;Recording of previous events;Relapse;Research Project Grants;Resistance;response;Role;Signal Transduction;Specimen;Sphingolipids;sphingosine 1-phosphate;Surface;targeted treatment;Testing;transcriptome sequencing;triple-negative invasive breast carcinoma;tumor;tumor progression;Tumor Tissue;Work;wound healing

PROJECT_TITLE: The role of ceramide kinase in metastasis growth from aggressive breast cancer


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Neurosciences;Prevention

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: Early diagnosis of diabetic eye disease is an important public health initiative as it is the leading cause of preventable vision loss in working aged Americans. It is known that color vision is altered in diabetes, but it is not known if color differences vary across the eye, change with retinopathy development, are correlated with other early diabetes tests, or even exactly which color channels and cells are definitively involved. The study will further develop a novel technique to evaluate color changes at different locations within the eye and will use this technique in patients with and without diabetes and prediabetes to learn more about ocular changes in this disease process.

PI_NAMEs: COATES, DANIEL ROBERT (contact);HARRISON, WENDY W

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Adult;Affect;Aftercare;Age;aged;American;Anatomy;Area;Awareness;Biological Markers;Blindness;Blood Glucose;Blood Pressure;Blood Vessels;Body fat;Body Size;Calibration;Cells;central visual field;Cholesterol;Clinical;cohort;Color;color category;Color Perception;color processing;Color Visions;Cone;Custom;Data;Development;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Diagnosis;Discrimination;Disease;Disease Management;Disease Progression;Early Diagnosis;Edema;Electroretinography;Epidemic;Evaluation;Eye;Eye diseases;falls;Foundations;fovea centralis;fundus imaging;Fundus photography;Future;Glaucoma;glycemic control;Glycosylated hemoglobin A;Goals;Health;illness length;Impairment;improved;Knowledge;koniocellular;Learning;Location;Longitudinal Studies;macular edema;Measures;Methods;Nature;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;outcome prediction;parvocellular;Pathology;Pathway interactions;Patients;Perimetry;Prediabetes syndrome;Process;Public Health;Radial;Recovery;Research;Retina;Retinal Diseases;Spatial Distribution;Spottings;System;Techniques;Testing;Thinness;Time;tomography;Treatment outcome;Variant;Vision;Vision Tests;Visual Fields;Visual Pathways;Work

PROJECT_TITLE: Characterizing the spatial distribution of color vision deficiencies in diabetes and prediabetes

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Arrhythmogenic cardiomyopathy (ACM) is a disease characterized by progressive fibrofatty replacement of the myocardium, arrhythmias, and sudden death. The mechanisms associated to fibrofatty myocardial infiltration need to be investigated to uncover therapeutic targets to improve ACM clinical management. Here we propose to develop a fibrofatty 3D model engineered cardiac tissue (EngCT), which will provide a system to study the pathogenesis of cardiac fibrofatty infiltration.

PI_NAMEs: CAL Y MAYOR-TURNBULL, IRENE  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adipocytes;Architecture;Arrhythmia;arrhythmogenic cardiomyopathy;Atrial Natriuretic Factor;Bioinformatics;Biomedical Engineering;Biomedical Technology;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cell Differentiation process;cell type;Cells;cellular targeting;Clinical Management;coronary fibrosis;Coupling;Cues;Defect;Deposition;Desmosomes;Development;Disease;disease model;Electrophysiology (science);Engineering;Environment;Epicardium;Epithelium;Evaluation;Fatty acid glycerol esters;FGF2 gene;Fibroblasts;Fibrosis;Gene Mutation;Genes;Genetic;Goals;Health;Heart;Heart Diseases;Heart failure;heart function;Human;human induced pluripotent stem cells;human model;Impairment;improved;In Vitro;Infiltration;lipid biosynthesis;Mesenchymal;Modeling;Molecular;Molecular Profiling;Mutation;Myocardial;Myocardial dysfunction;Myocardium;new therapeutic target;novel;novel strategies;Pathogenesis;Pathologic;patient derived induced pluripotent stem cells;Patients;Phenotype;Physiological;Physiology;Property;Relaxation;Reporting;Role;Science;Source;stem cell technology;Sudden Death;System;Techniques;Therapeutic;therapeutic target;three-dimensional modeling;Tissue Engineering;Tissue Model;transcriptomics;Ventricular Dysfunction

PROJECT_TITLE: Novel bioengineering models to dissect cardiac cell-cell defects in arrhythmogenic cardiomyopathy

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Mitochondrial dysfunction associates with the majority of age-dependent pathologies, including Alzheimer’s disease, cardiovascular disease, diabetes and cancer. This proposal aims to identify new strategies in bolstering mitochondrial function later into life, thus promoting public health by targeting a common, underlying cause of diverse forms of age-onset disease.

PI_NAMEs: BURKEWITZ, KRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Age of Onset;age related;age-related disease;Aging;aging mechanism;aging related;Alzheimer's Disease;Anatomy;animal old age;Animals;Behavior;Bioenergetics;Biological;Caenorhabditis elegans;Calcium;Calcium Signaling;Cardiovascular Diseases;cell type;Cells;Communication;Complex;Coupled;Data;Defect;Diabetes Mellitus;Disease;Electron Transport;Endoplasmic Reticulum;Engineering;experimental study;extend lifespan;Foundations;Functional disorder;Gene Expression;Genetic;genetic analysis;genetic manipulation;Goals;hallmarks of aging;Health;healthspan;Homeostasis;Impairment;Inositol;Intervention;Lead;Life;life span;Link;Longevity;Longevity Pathway;Maintenance;Malignant Neoplasms;Mammals;Mediating;Mediator;Membrane;Metabolism;Microscopy;Mitochondria;mitochondrial dysfunction;mitochondrial fitness;mitochondrial therapeutics;Modeling;Molecular;Morphology;mutant;Neurons;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Onset of illness;Organelles;Pathology;Pathway interactions;Physiological;Porifera;Process;Proteomics;Public Health;receptor;receptor function;Regulation;release of sequestered calcium ion into cytoplasm;Role;Rough endoplasmic reticulum;Shapes;Signal Transduction;Site;spatiotemporal;Structure;Study models;Testing;Tissues;tripolyphosphate;Work

PROJECT_TITLE: Targeting ER-mitochondrial calcium signaling to promote healthier aging

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Digestive Diseases;Nutrition

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Approximately 1 in 10 Americans has type 2 diabetes, with its prevalence alarmingly increasing in younger adults. This study will identify the mechanism by which the transcription factor hypoxia inducible factor-2a promotes GLP1 secretion and metabolic homeostasis. Given the profound glucoregulatory effect of GLP1, the outcomes of our project may help us identify novel targets to treat diabetes by stimulating endogenous GLP1.

PI_NAMEs: RAMAKRISHNAN, SADEESH KUMAR  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Acute;alpha ketoglutarate;American;Attenuated;B-Lymphocytes;bariatric surgery;bHLH-PAS factor HLF;blood glucose regulation;Cell Physiology;Cells;Cues;Data;detection of nutrient;Diabetes Mellitus;diabetic patient;Diarrhea;Diet;dietary;Dietary Supplementation;Dose;Dose Limiting;Enzymes;Epithelial Cells;Epithelium;Event;Fasting;Fatty Acids;Fatty Liver;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;GCG gene;Genes;glucagon-like peptide 1;Glucose Intolerance;glucose tolerance;glycemic control;Goals;Homeostasis;Human;Hyperglycemia;Hypoglycemia;Hypoxia Inducible Factor;Immune;improved;inhibitor;insight;intestinal epithelium;intestinal hypoxia;Intestines;L Cell (Intestine);L Cells;Link;Lipids;loss of function;Metabolic;Metabolic Diseases;metabolomics;Molecular;Mus;Nausea;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Nutrient;Nutritional;Organoids;Outcome;Oxygen;Patient Compliance;Patients;Prevalence;promoter;response;Risk;Role;sensor;Signal Pathway;Signal Transduction;Small Intestines;System;Testing;Tracer;transcription factor;Type 2 diabetic;Work;young adult

PROJECT_TITLE: Role of Hypoxia-inducible factor-2a in L-cell nutrient sensing and metabolic homeostasis

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Human genomes harbor significant variation within and between individual tissues, referred to as somatic mosaicism. Investigations into this phenomenon have been mostly limited to higher frequency mosaicism and certain variant types (SNVs, large deletions) due to technical limitations in both molecular assays and computational methodology. This proposal seeks to overcome these limitations by developing and deploying innovative sequencing technologies and computational approaches to identify somatic variation across the frequency spectrum for multiple variant types.

PI_NAMEs: BOYLE, ALAN P;MILLS, RYAN E (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;analysis pipeline;Bar Codes;Benchmarking;Biological Assay;Brain;Cataloging;Cell Fraction;Cell Nucleus;Cells;Centrifugation;Cloud Computing;Complement;Computer software;computerized tools;Computing Methodologies;Copy Number Polymorphism;Data;density;Development;disease phenotype;Disease susceptibility;DNA Insertion Elements;Event;Exhibits;exome sequencing;experience;Frequencies;Gastric Glands;Gene Frequency;Genetic Polymorphism;genetic variant;Genome;genome sequencing;Genomics;Germ Lines;Goals;high throughput screening;Human;Human Genome;human tissue;improved;Individual;Inherited;innovation;Investigation;iodixanol;Large Intestine;Link;Malignant Neoplasms;Molecular;mosaic;Mosaicism;Mutation Detection;nanopore;open source;Output;Percoll;personalized approach;Phase;Phenotype;Population;Preparation;Prevalence;Prostate;Reporting;Resolution;Retrotransposon;Running;Short Tandem Repeat;single cell sequencing;Single Nucleotide Polymorphism;Small Intestines;software repository;Somatic Mutation;Standardization;Structure;Surveys;targeted sequencing;Technology;Testing;Time;Tissues;tool;trait;Variant;whole genome;Work;zygote

PROJECT_TITLE: Molecular and Computational Tools for Identifying Somatic Mosaicism in Human Tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-K(70)R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The proposed research is relevant to public health. Our study focuses on understanding the mechanisms driving the racial disparities in patients with multiple myeloma. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to developing fundamental knowledge that will help to reduce the burdens of human disability.

PI_NAMEs: KANG, YUBIN  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Affect;African American;African American population;Age;Antibodies;Archives;Automobile Driving;B lymphocyte-induced maturation protein 1;Binding;Biological Assay;Biological Markers;Biopsy Specimen;Blood;Bone marrow biopsy;Bone Marrow Transplantation;Caring;cell growth;Cells;Characteristics;chromatin immunoprecipitation;Chromosomal translocation;Chromosome abnormality;Clinical;comorbidity;crosslink;Cytogenetics;Data Mart;disability;Disease;Disparity;economic determinant;effective therapy;Effectiveness;Exhibits;experience;Family member;FDA approved;Genetic Transcription;Genotype;Goals;Hematologic Neoplasms;high risk;Human;improved;Incidence;Inferior;innovation;Knowledge;Length;Luciferases;Malignant Neoplasms;Mediating;Medical Records;Messenger RNA;Mission;Molecular Abnormality;Monoclonal Antibodies;Multiple Myeloma;Mutation;new technology;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Persons;Plasma Cells;Play;Population;promoter;protein expression;Public Health;Race;racial disparity;Refractory;Regimen;Reporter;Research;response;Retrospective cohort study;Role;Secondary to;Single Nucleotide Polymorphism;Site-Directed Mutagenesis;SLAM protein;social;Stem cell transplant;System;Testing;therapeutic target;translational impact;Treatment Protocols;tumorigenesis;United States;United States National Institutes of Health;Up-Regulation;Work

PROJECT_TITLE: Role of SLAMF7 in Racial Disparities in Myeloma

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Nanotechnology;Regenerative Medicine;Transplantation

ORG_CITY: LOS ANGELES

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Relevance to Public Health The proposed research provides a new strategy to improve clinical efficacy of current bone graft therapeutics for accelerated bone repair. Results from these studies will improve health for millions of people with skeletal defects.

PI_NAMEs: LEE, MIN  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Acceleration;Adverse effects;antagonist;Autologous;Autologous Transplantation;biomechanical test;Blood;BMP2 gene;bone;bone healing;Bone Matrix;Bone Morphogenetic Proteins;Bone Regeneration;bone repair;Bone Transplantation;Calvaria;Catechols;Cells;Characteristics;Chemistry;Chitosan;clay;clinical application;clinical efficacy;Containment;cortical bone;Craniofacial Abnormalities;crosslink;Crosslinker;Defect;delivery vehicle;demineralization;design;Dose;Engineering;Environment;Excipients;exosome;extracellular vesicles;Feedback;Goals;Harvest;healing;Health;Histologic;Hydrogels;Implant;implantation;improved;In Situ;In Vitro;Injectable;intercellular communication;intermolecular interaction;Irrigation;Kinetics;Mandible;media use;Mediating;Mesenchymal Stem Cells;microCT;mimetics;Minerals;Modeling;Morbidity - disease rate;nano;nanocarrier;nanocomposite;nanosheet;Nature;Operative Surgical Procedures;Orthopedics;Osteogenesis;osteogenic;osteoinductive factor;particle;Particulate;Persons;Physiological;Phytochemical;Polymers;Process;Property;Public Health;Rattus;Reaction;Recombinants;reconstruction;Regenerative capacity;Repair Material;repaired;Research;RNA Interference;Safety;self assembly;Signaling Protein;Silicon Dioxide;Site;skeletal;Small Interfering RNA;Small RNA;Suspensions;System;Therapeutic;Transfection;treatment site;vector;Viscosity;Work

PROJECT_TITLE: Hydrogel delivery of DBM and exosome mimetics for bone repair

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Chronic wasting disease (CWD) is a highly contagious disease of elk and deer with considerable zoonotic potential. It is caused by prions, unusual pathogens comprised of misfolded, aggregated proteins. Elucidating the structure of these pathogens in different phenotypes (strains) of CWD is of major importance for understanding the pathogenic process and future development of therapeutic approaches.

PI_NAMEs: SUREWICZ, WITOLD K (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Address;American;Amides;Animals;Asian;Biochemical;Biological Assay;Biological Models;Biology;Brain;Brain Diseases;Cell Culture Techniques;cervid;Characteristics;Chronic Wasting Disease;Complex;conformational conversion;Country;cross-species transmission;Cryoelectron Microscopy;Deer;Deuterium;Disease;Epidemic;European;Family;foot;Foundations;Future;Gene Targeting;Glutamates;Glutamine;Goals;Heritability;Heterozygote;Histidine;Human;Hydrogen;Hydroxyl Radical;In Vitro;in vivo;Infectious Agent;insight;Knowledge;Laboratories;Lead;Maintenance;Mass Spectrum Analysis;member;Methods;Molecular;Molecular Conformation;mouse model;Mus;Neurodegenerative Disorders;novel;Nucleic Acids;pathogen;Pathogenicity;Peripheral;pharmacologic;Phenotype;Physiological;Printing;Prion Diseases;Prions;Process;Property;protein aggregation;Proteins;PrP;PrPSc Proteins;Public Health;Reindeer;Research;Resolution;Resources;Risk;Rodent;Route;Scandinavian;structural biology;Structure;Study models;Susceptibility Gene;Testing;therapeutic development;tool;transmission process;Variant;Vertebral column;Zoonoses

PROJECT_TITLE: Structural diversity of cervid prions and phenotypic variation of chronic wasting disease

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: AURORA

ORG_NAME: NEUREXIS THERAPEUTICS, INC.

ORG_STATE: CO

PHR: Project Narrative Stroke afflicts nearly 800,000 Americans each year and often results in permanent cognitive impairment or death, leading to over $35 billion in annual healthcare costs in the US. This project will evaluate our lead cerebroprotective compound, tatCN19o, as an ischemic stroke therapy through comparative testing within the NINDS Stroke Preclinical Assessment Network (SPAN).

PI_NAMEs: ASFAHA, OLIVIA RUTH;GOFORTH, ROBYN L (contact)

PROGRAM_OFFICER_NAME: JANIS, SCOTT

PROJECT_TERMS: Activase;Acute;Adult;aged;Alteplase;American;Amino Acids;animal old age;Animals;aortic arch;Blood coagulation;calmodulin-dependent protein kinase II;Cell Death;Cerebral Ischemia;cerebroprotection;Cessation of life;Chemistry;Clinical;clinical risk;Clinical Trials;Coagulation Process;Collaborations;comparative;Consensus;Development;Dose;efficacy evaluation;Excision;excitotoxicity;Family suidae;FDA approved;Filament;follow-up;Funding;Future;Germ Cells;Health Care Costs;Human;hypertensive;Impaired cognition;improved;in vivo;in vivo Model;inhibitor;Intervention;Ischemia;Ischemic Stroke;Lead;Magnetic Resonance Imaging;manufacture;Marketing;mature animal;Mechanics;Middle Cerebral Artery Occlusion;model development;Modeling;mouse model;Mus;National Institute of Neurological Disorders and Stroke;Neurons;neuroprotection;Operative Surgical Procedures;Parents;participant enrollment;Patients;peptide drug;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;pharmacologic;Phase;Phase III Clinical Trials;phase III trial;Plasmin;Population;post stroke;pre-clinical assessment;Property;Rattus;Reperfusion Injury;Reporting;Risk;Rodent;safety study;severe injury;sex;Site;Small Business Innovation Research Grant;standard of care;Standardization;Stimulus;Stroke;stroke model;stroke risk;stroke therapy;Symptoms;Tenecteplase;Testing;Therapeutic;Time;Toxicology;Variant;Water

PROJECT_TITLE: Comparative testing of tatCN19o for neuroprotection in rodent tMCAo


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Disability Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Patient Safety;Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Deprescribing (i.e., discontinuing or de-intensifying) medications with reduced benefits and increased harms is a priority for older adults (OAs) with Alzheimer’s Disease and Related Dementias (ADRD), who face a high medication burden and increased vulnerability to adverse drug reactions. Aspirin for primary or secondary cardiovascular prevention has been proposed as a possible target medication that may be safely discontinued, but there is little evidence about the impact of discontinuing aspirin on health outcomes in OAs with ADRD to support deprescribing decisions. This study will use real-world healthcare data to examine patterns, benefits, and harms of discontinuing aspirin in older nursing home residents with ADRD.

PI_NAMEs: THORPE, CAROLYN TIMBERLAKE (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Accident and Emergency department;Address;Admission activity;Adult;adverse drug reaction;Age;Alzheimer's disease related dementia;Anti-Inflammatory Agents;Aspirin;Atherosclerosis;atherosclerosis risk;Attention;Bar Codes;Behavioral;Benefits and Risks;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Caregivers;Clinical;Cognition;cognitive function;cohort;Data;Data Set;Decision Making;Dementia;Demographic Factors;design;disability;discontinuation trial;Dose;Drug Interactions;Elderly;Electronic Health Record;Emergency department visit;empowerment;Epidemiologic Methods;Event;Exclusion;experience;Family;frailty;functional decline;Functional dependence;Future;Goals;Guidelines;Health;health assessment;Health Status;Health system;Healthcare;Hemorrhage;Hospitalization;human old age (65+);Impaired cognition;improved;Life Expectancy;Link;Medicare;medication administration;Methods;Modeling;mortality;National Institute on Aging;Non-Prescription Drugs;Nursing Homes;Observational Study;older adult;Outcome;Palliative Care;patient oriented;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Pharmacoepidemiology;Policies;Polypharmacy;Population;Positioning Attribute;Practice Guidelines;Predictive Factor;prevent;Prevention;Prevention trial;Preventive;Primary Prevention;Probability;Prognosis;Provider;psychological symptom;Quality of Care;Randomized;randomized trial;Recommendation;Records;Regimen;Research;Research Priority;Retrospective cohort study;Risk;Secondary Prevention;Selection Bias;Signal Transduction;socioenvironmental factor;Structural Models;thrombotic;Time;Translating;treatment duration;treatment guidelines;Uncertainty;United States Department of Veterans Affairs;Variant;World Health

PROJECT_TITLE: Health Outcomes of Discontinuing Aspirin in Older Adults with Alzheimer's Disease and Related Dementias

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SAINT LOUIS

ORG_DEPT: GENETICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  The WashU Somatic Mosaicism across Human Tissues Program Organizational Center (SMaHT-OC) will serve as the nucleus for facilitating all activities of the SMaHT Network. We will define rules and mechanisms of communication, will empower researchers to engage with multimodal "big bio-data", and will provide administrative and budget support for developing and managing engagement and training. Through innovative methodology, we will establish a research environment that promotes collaboration, coordination, and communication among SMaHT Network participants and the scientific community. .

PI_NAMEs: FULTON, LUCINDA ;LAWSON, HEATHER A.;WANG, TING  (contact)

PROJECT_TERMS: Adoption;Affect;Autopsy;Bioinformatics;Biological;Biological Process;Budgets;Cancer Etiology;Cataloging;Cell Nucleus;Collaborations;Communication;Communication Tools;Communications Media;Communities;Complex;Consensus;Data;data format;data management;data portal;data sharing;data visualization;design;Development;Disease;Documentation;Educational workshop;Elements;empowerment;Environment;epigenome;experience;feasibility testing;Funding;Genome;genome resource;genomic variation;Genomics;Goals;Health;Human;human pangenome;human tissue;implementation strategy;Individual;Infrastructure;innovation;Lead;life span;Manuals;Mediating;meetings;Methodology;Methods;Mosaicism;multimodality;National Human Genome Research Institute;Network-based;Newsletter;novel;operation;Outcome;outreach;Participant;Pilot Projects;Policies;Press Releases;programs;Protocols documentation;Publications;Reporting;Research;Research Personnel;Research Support;Resources;Retrieval;Sampling;social media;Somatic Mutation;Techniques;Time;Tissues;Training;Transfer Agreement;United States National Institutes of Health;user-friendly;Variant;Visit;Visualization;web site;webinar;working group;Writing

PROJECT_TITLE: WashU Somatic Mosaicism across Human Tissues (SMaHT) Program Organizational Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-D(70)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Disability Research;Genetics;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: TUCSON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative: The brain damage is far too common in the preterm neonates. The proposed research will identify the mechanism to prevent brain damage in the preterm neonates. The research will be conducted in vivo in the preterm fetus to identify therapeutically relevant targets to control blood flow to the brain.

PI_NAMEs: GOYAL, RAVI  (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Adrenergic Agents;Adrenergic Receptor;Affect;alpha-1 adrenergic receptors;Animals;Basic Science;Biological Assay;Birth;Blood flow;Brain;Brain Injuries;Caring;Carotid Arteries;Catheterization;cerebral autoregulation;cerebral capillary;Cerebrovascular Circulation;Cerebrum;Child;Chronic;Circulation;cognitive disability;constriction;Data;demethylation;Development;differential expression;disability;Disabled Persons;DNA Methylation;Epigenetic Process;Epinephrine;Excision;Expenditure;experimental study;Face;Family;fetal;Fetal Sheep;Fetus;gene network;Gestational Age;Healthcare;Homeostasis;Hormones;Hour;Human;Impairment;in utero;in vivo;Incidence;Infant;insight;Laser-Doppler Flowmetry;Learning Disabilities;Life;life-long learning;mature animal;Measurement;Measures;Mediating;Methylation;mRNA Expression;neonate;Neurologic;Norepinephrine;Outcome;Pathology;Pathway interactions;Perinatal subependymal hemorrhage;Periventricular Leukomalacia;Play;Premature Infant;pressure;preterm newborn;prevent;promoter;receptor;Regulation;Research;Resources;response;Role;Rupture;Series;sex;Sheep;Side;Stress;Structure of superior cervical ganglion;Sympathetic Nervous System;System;Systemic blood pressure;Term Birth;Testing;Therapeutic;Time;transcription factor

PROJECT_TITLE: Alpha Adrenergic Methylation and Developmental Maturation of Cerebral Autoregulation in Ovine Preterm Fetus

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Lung;Pulmonary Hypertension

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE This project will evaluate whether advanced analysis of the pulmonary blood vessels on chest imaging can identify individuals who are at risk for complications related to interstitial lung disease. These results may help physicians recognize which patients with interstitial lung disease would benefit from earlier treatment and may prevent certain severe complications from developing – an important step to improving the long-term health of people living with this chronic lung disease.

PI_NAMEs: SYNN, ANDREW  (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Activities of Daily Living;Address;antifibrotic treatment;Award;Blood Vessels;Cardiac Catheterization Procedures;career development;catalyst;Cessation of life;Chest imaging;Chronic lung disease;Clinic;Clinical;clinical biomarkers;clinical care;clinically actionable;cohort;Data;design;Development;Diagnosis;Disease Outcome;Disease Progression;Early treatment;Echocardiography;effective therapy;Environment;Epidemiologic Methods;Evaluation;Event;exercise capacity;Exercise Test;experience;Fibrosis;follow-up;Future;Goals;Grant;Guidelines;Health;hemodynamics;high risk;Histologic;Hospitalization;Hospitals;Image;Image Analysis;Imaging Device;improved;improved outcome;Individual;Inhalation;innovation;Institution;interstitial;Interstitial Lung Diseases;Israel;Laboratories;Learning;Link;longitudinal analysis;Lung;Lung Diseases;Lung Transplantation;Measures;Medical center;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Methods;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;National Heart, Lung, and Blood Institute;Outcome;Outcome Measure;Participant;Pathogenesis;Patient Care;Patients;Persons;Pharmacotherapy;Phenotype;Physicians;Positioning Attribute;prevent;Progression-Free Survivals;prospective;Prospective cohort;Prospective Studies;Public Health Schools;Pulmonary Fibrosis;pulmonary function;Pulmonary function tests;Pulmonary Hypertension;pulmonary vascular disorder;Pulmonary vessels;quantitative imaging;recruit;Research Personnel;Resources;respiratory morbidity;Right Ventricular Function;Risk;risk stratification;Scanning;screening;skill acquisition;skills;Source;Specialist;Statistical Methods;Surveys;Survival Analysis;Symptoms;Techniques;Testing;Time;tool;Training;treatment strategy;Treprostinil;vascular abnormality;Vasodilator Agents;virtual;Vital capacity;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Pulmonary Vascular Pruning on Computed Tomography and Interstitial Lung Disease Outcomes


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE The proposed studies will investigate the association of chronic periodontitis with the hallmark pathologic features of Alzheimer’s Disease. More specifically, we will address the role of a new class of dihydroceramide lipids, named phosphoglycerol dihydroceramide (PGDHC), produced by the key periodontal pathogen Porphyromonas gignivalis in phosphorilation of tau and amyloid pathology using mouse models of periodontatititis and Alzheimer’s disease.

PI_NAMEs: MOVILA, ALEXANDRU  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Address;age related;age related neurodegeneration;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid pathology;amyloid precursor protein processing;amyloidogenesis;Apoptosis;Appointment;Award;Bacteria;Basic Science;Blood - brain barrier anatomy;Brain;C-terminal;career;career development;Cells;Ceramides;Clinical;Clinical Trials;Collaborations;Credentialing;cytokine;Dental Students;dihydroceramide;Doctor of Philosophy;Educational process of instructing;experience;Experimental Models;Faculty;Florida;Foundations;frontal lobe;Functional disorder;Future;gingipain;Gingiva;Goals;Grant;Hippocampus;Human;human tissue;hyperphosphorylated tau;improved;In Vitro;in vivo;Independent Scientist Award;Inflammation;Inflammatory;Injections;Innate Immune Response;interest;Knowledge;Learning;Lesion;Lipids;Lipopolysaccharides;Mediating;Mentors;mid-career faculty;Modeling;Molecular;Molecular Weight;mouse model;Mus;Names;National Institute of Dental and Craniofacial Research;National Institute on Aging;Neurofibrillary Tangles;neuroimmunology;neuropathology;novel;novel therapeutic intervention;Oral;oral bacteria;oral biology;oral immunology;oral pathogen;Pathogenesis;Pathogenicity;Pathologic;Patients;Peptide Hydrolases;Periodontal Diseases;Periodontitis;periodontopathogen;Permeability;Porphyromonas;Porphyromonas gingivalis;pre-clinical;Production;professor;Publications;Publishing;Reporting;Research;Research Personnel;research study;Risk Factors;Role;Scientist;Signal Transduction;skills;tau Proteins;tau-1;Testing;Time;Tissues;Training;undergraduate student;Universities;Virulence Factors;Virulent;Wild Type Mouse;Workload

PROJECT_TITLE: Roles of Periodontal Bacteria-Derived Dihydroceramides in Alzheimer's Disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Biological Aging Study Section[NIA-B]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative: Bronchopulmonary dysplasia (BPD) is a common lung disease in premature babies. We discovered that increases in the microRNA let-7b-5p as early as birth strongly predict which infants will later develop BPD. In this project, we will find out if increases in this microRNA in human preterm infants at later time points is also predictive, and we will use mouse models and cell cultures to see if this microRNA is increased by oxygen exposure and causes BPD by decreasing blood vessels in the lung.

PI_NAMEs: AMBALAVANAN, NAMASIVAYAM  (contact)

PROGRAM_OFFICER_NAME: NATARAJAN, ARUNA R

PROJECT_TERMS: Adult;Age;airway epithelium;Alveolar;angiogenesis;Angiogenesis Inhibition;aspirate;Attenuated;Basic Science;Biological Markers;biomarker identification;Birth;Blood;Blood Vessels;Bronchopulmonary Dysplasia;Cell Culture System;Cell Culture Techniques;Cessation of life;Clinical;cohort;cytokine;Development;Disease Progression;Early identification;Epithelial Cells;exome sequencing;extreme prematurity;Extremely Low Birth Weight Infant;Fetal Lung;Functional disorder;genome wide association study;Genomics;Human;Hyperoxia;Impairment;improved;Incidence;Infant;inhibitor;Lung;lung development;Lung Diseases;Measures;Mechanics;Mediator;Messenger RNA;metabolomics;Metagenomics;microbial;microbiome;microbiome research;MicroRNAs;Mitochondria;Modeling;Monitor;Morbidity - disease rate;mouse model;Mus;neonatal airway;Newborn Infant;NF-kappa B;normoxia;novel;novel therapeutic intervention;overexpression;Oxidative Stress;Oxygen;Phenotype;Plasma;postnatal;Premature Infant;premature lungs;prospective;Prospective cohort;Proteomics;Pulmonary Fibrosis;pulmonary function;Pulmonary Hypertension;Research;respiratory;Risk;Role;Sampling;Severity of illness;Signal Transduction;Small RNA;Source;Staging;Structure of parenchyma of lung;Testing;Time;Trachea;transcriptome sequencing;transcriptomics;Transgenic Mice;treatment response;Urine;Vascular remodeling

PROJECT_TITLE: Let-7b in BPD

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Heart Disease

ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Implantable vascular devices such as stents help to save the lives of millions of people with vascular disease every year. These vascular devices often fail over time and the daily medications which are required to prevent blood from clotting, negatively impact patients. This project will develop alloys of biodegradable metals which meet the mechanical and biological requirements of vascular stents to prevent device failure and improve patient lives.

PI_NAMEs: GOLDMAN, JEREMY ;HINDS, MONICA T (contact)

PROJECT_TERMS: Alloys;Anticoagulants;Arteries;Biocompatible Materials;biodegradable polymer;Biodegradation;Biological;biomaterial compatibility;bioresorption;Blood Cells;Blood coagulation;Blood Platelets;Blood Vessels;Cardiac;Cardiovascular Diseases;Cell Physiology;Chromium;Clinical;Cobalt;Copper;Corrosion;Data;design;Devices;Dimensions;Elements;Environment;Enzyme Precursors;Equipment Malfunction;Exhibits;Failure;Goals;Grain;Heart Diseases;hemocompatibility;Hydroxides;Implant;improved;In Vitro;in vivo;Inflammatory Response;interest;Ions;Iron;Legal patent;Life;Magnesium;manufacture;mechanical properties;Mechanics;metallicity;Metals;Modeling;Modification;monocyte;Morbidity - disease rate;mortality;nanosized;neutrophil;nitinol;nonhuman primate;Oxides;Patients;Performance;Peripheral;Persons;Pharmaceutical Preparations;Polymers;preclinical study;Preclinical Testing;prevent;Process;Property;response;restenosis;scaffold;Stainless Steel;Stents;Structure;Sulfides;Surface;Surface Properties;Techniques;Technology;Testing;thrombogenesis;thromboinflammation;Thrombosis;Time;Translations;Vascular Diseases;Vascular System;Work;Zinc

PROJECT_TITLE: Biodegradable Metal Stent Alloys for Vascular Applications

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;HIV/AIDS;Hypertension;Infectious Diseases;Kidney Disease;Pediatric

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE These studies will elucidate new mechanisms whereby the HIV-cytokine milieu interacts with the renin angiotensin system (RAS) to modulate the outcome of childhood HIV-renal diseases. In addition, they will generate new information and biomarkers to monitor the outcome of children and adolescents living with HIV and treated long-term with RAS inhibitors to prevent the development of hypotension and silent renal ischemia.

PI_NAMEs: RAY, PATRICIO E. (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Adult;Affect;African ancestry;AIDS-Associated Nephropathy;Angiotensin-Converting Enzyme Inhibitors;Annexins;antiretroviral therapy;arteriole;Biological Markers;Black race;Blood Pressure;blood pressure reduction;Cardiovascular system;CD4 Positive T Lymphocytes;Cells;Child;Childhood;Chronic;Chronic Kidney Failure;cytokine;Data;Development;dietary;Electrolyte Balance;Electrolytes;Enalapril;Epithelial Cells;Equilibrium;Event;FGF2 gene;Fibroblast Growth Factor;Fluid Balance;FRS2 gene;HIV;HIV-infected adolescents;Homeostasis;Hypertension;hypertensive;Hypotension;Hypotensives;Impairment;infancy;Infection;Inflammatory;inhibitor;Injury to Kidney;Kidney;Kidney Diseases;kidney vascular structure;Knockout Mice;Knowledge;Lesion;Life;Macrophage;Mediating;Membrane;Modeling;Monitor;Mononuclear;Mus;Outcome;particle;Pathogenesis;Pathway interactions;Perfusion;Persons;Physiological;Play;podocyte;Prevalence;prevent;Process;programs;Protein Secretion;Proteins;Proteinuria;receptor;renal epithelium;Renal Hypertension;renal ischemia;Renin;Renin-Angiotensin System;response;Risk Factors;Role;Signal Transduction;Sodium Chloride;Structure;Tamoxifen;Testing;time use;TNF gene;transcriptome;transcriptomics;Tubular formation;Viral;Wasting Syndrome;Water

PROJECT_TITLE: Pathogenesis of renal injury and hypertension in HIV+ children

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MERCED

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, MERCED

PHR: PROJECT NARRATIVE: Hedgehog signaling is widely implicated in development and disease, and its signaling transduction relies in dynamic protein trafficking in and out of the primary cilium, a special cell surface organelle. Many questions remain open regarding the protein transport and signaling relay mechanisms within the cilium. We propose to shed light on these standing questions with a functional proteomic study to discover new signaling transducers during the time course of hedgehog signal activation, and to determine the molecular mechanisms of Hedgehog pathway regulation by these new signaling components in vitro and in vivo.

PI_NAMEs: GE, XUECAI  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Adaptor Signaling Protein;base;Biotinylation;Brain;Cell division;Cell Line;Cell Physiology;Cell surface;Cells;Cilia;Congenital Abnormality;Cultured Cells;Data;Defect;Development;developmental disease;Disease;Drosophila genus;effective therapy;Embryo;Endocytosis;Erinaceidae;Future;G-Protein-Coupled Receptors;Goals;hedgehog signal transduction;In Vitro;in vivo;innovation;insight;Intervention;Knockout Mice;Label;Ligands;Malignant Neoplasms;Mediating;Methods;Molecular;mouse model;nerve stem cell;neurodevelopment;neurogenesis;neuroregulation;novel;Numbness;Organelles;Pathway interactions;Phase;Phenocopy;premature;Process;progenitor;Proliferating;Protein Dynamics;protein transport;Proteins;Proteomics;receptor;receptor internalization;Regulation;Research;Rest;Role;Signal Transduction;Signaling Protein;smoothened signaling pathway;stable cell line;stem cell proliferation;success;Testing;therapeutic development;Time;tool;trafficking;Transducers;Transportation;Work

PROJECT_TITLE: Regulation of the Hedgehog Pathway by new cilium proteins in Development and Disease

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Arthritis;Behavioral and Social Science;Brain Disorders;Caregiving Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Dissemination and Implementation Research;Neurodegenerative;Neurosciences;Osteoarthritis;Pain Research;Palliative Care;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative Chronic musculoskeletal pain, specifically osteoarthritis (OA) of the knee, is common among community-dwelling people living with dementia and associated with cascading negative consequences on physical function limitations, quality of life decline, and caregiver burden; however, few beneficial and appropriate treatment options exist. This study seeks to use evidence, theory, and stakeholder input to design an exercise-based intervention for knee OA pain management that is tailored to the interests, preserved abilities, and biopsychosocial-environmental needs of community-dwelling older adults with mild to moderate dementia. Findings from K23 research will yield a nonpharmacological intervention prototype and delivery parameters that will inform a future efficacy study and have a strong potential for preserving or improving the quality of life of community-dwelling older adults with dementia and OA.

PI_NAMEs: NA, ANNALISA  (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Acceleration;acceptability and feasibility;Adult;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Analgesics;Arts;Behavior;Behavior Therapy;Biological;biopsychosocial;Boxing;career;career development;Caregiver Burden;Caregivers;Characteristics;Chronic;chronic musculoskeletal pain;chronic pain;chronic pain management;Clinical;Clinical Management;Clinical Trials;Cognitive;college;Communities;community intervention;comorbidity;Complex;Creativeness;Dancing;Data;Degenerative polyarthritis;Dementia;dementia care;Department chair;design;Development;Discipline of Nursing;distinguished professor;Doctor of Philosophy;Dose;efficacy study;efficacy testing;Environment;Environmental Risk Factor;evidence base;Exclusion;Exercise;exercise program;experience;falls;Focus Groups;Funding;Future;Goals;Health care facility;Health Occupations;Health Services Accessibility;Home;Hybrids;implementation science;improved;Individual;innovation;interest;Intervention;intervention program;Interview;Joints;Knee;Knee Osteoarthritis;knee pain;Knowledge;Leadership;Learning;lens;Long-Term Care;Maps;Massage;Measures;Medical;Medicine;Mentors;Methodology;mid-career faculty;Mobility decline;Modeling;Muscle;Music;Neurologist;Neurology;Neurosciences;non-drug;Nonpharmacologic Therapy;novel;Numeric Rating Scale;Nurses;older adult;osteoarthritis pain;Outcome;Pain;Pain management;Participant;Patients;Perception;personalized approach;Persons;Physical Function;Physical Rehabilitation;physical therapist;Physical therapy;Premature Mortality;preservation;Primary Care Physician;professor;programs;prototype;Psychosocial Factor;Quality of life;rehabilitation science;Reporting;Research;Research Assistant;Research Methodology;Research Personnel;Scientist;skills;standard care;statistics;Structure;Testing;theories;Therapeutic;therapy development;Training;Training Activity;Translations;Treatment Efficacy;trial design;Universities;Utah;Weight-Bearing state

PROJECT_TITLE: Developing a nonpharmacological pain intervention for community dwelling older adults with dementia

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative  This training grant will help to educate graduate and postdoctoral trainees in biomedical entrepreneurship to allow them to take research discoveries from the lab and move them into the commercial space to create innovative diagnostic and therapeutic interventions to assist patients with Alzheimer's Disease and AD-Related Disorders (ADRD). It indudes coursework, experiential learning opportunities, and will help trainees prepare a pitch deck and subsequently, an NIH small-business grant in order to fund the next step of their product development pathway.

PI_NAMEs: GOONERATNE, NALAKA S (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Active Learning;Address;Alzheimer's Disease;Alzheimer's disease related dementia;American;Applications Grants;Area;Award;Biological Products;Businesses;Caregivers;Caring;Case Based Learning;Clinical;Clinical and Translational Science Awards;Clinical Research;commercialization;Communities;Complement;Country;curriculum development;Dedications;Development;Development Plans;Diagnostic;didactic education;digital health;Disease;diversity and inclusion;Ecosystem;Education;Education Projects;Educational Curriculum;Educational process of instructing;Educational workshop;electronic book;Elements;Engineering;Enrollment;Ensure;Entrepreneurship;experience;externship;Faculty;Family;Fund Raising;Funding;Future;Goals;Grant;Health;Healthcare;Healthcare Market;improved;Individual;innovation;Intellectual Property;interest;Investments;Knowledge;knowledge base;Lead;Learning;Learning Skill;Life;loved ones;Medical;Melatonin;Mentors;Mentorship;Mission;Modeling;Modification;Nature;older adult;Pathway interactions;Patients;Pennsylvania;Persons;Pharmacotherapy;Pilot Projects;Postdoctoral Fellow;Process;product development;programs;Provider;Public Health;Research;Research Personnel;Research Project Grants;Research Technics;Resources;Science;Scientist;skill acquisition;skills;Small Business Innovation Research Grant;Small Business Technology Transfer Research;small molecule;Structure;support network;Technology;Textbooks;Therapeutic;Therapeutic Intervention;Time;Training;Training Programs;Translational Research;Underrepresented Minority;United States;United States National Institutes of Health;Universities;Work;Workforce Development;Writing

PROJECT_TITLE: An Immersive, Interdisciplinary Training Program for Workforce Development and Sustained Engagement in Entrepreneurship and Translational Research for Alzheimer's Disease and Related Disorders


NIH_SPENDING_CATS: Neurosciences;Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE  Cells release chemical signals in a process known as exocytosis, whereby small packages of signaling molecules within cells are expelled into the surrounding fluid where they can act on other cells. Exocytosis has essential roles in virtually all forms of neuronal and endocrine signaling. A deeper understanding of the mechanisms of exocytosis will enable us to learn how the endocrine system orchestrates complex physiological changes in the body, and how the nervous system encodes sensory inputs and processes information. These insights will help us understand how to treat medical conditions involving aberrant hormone release in endocrine disorders, and impaired neuronal communication in mental illness, learning disorders, epilepsy, and other neurological diseases. Studies of exocytosis in human neurons will evaluate synaptic release in Down syndrome, fragile X mental retardation, Parkinson's disease, and tuberous sclerosis complex.

PI_NAMEs: JACKSON, MEYER B. (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Address;Aging;aqueous;Binding;Biological;biophysical techniques;Catecholamines;Cell membrane;Cells;chemical release;Coculture Techniques;Communication;Complex;Contracts;Data;Disease;DLG4 gene;Down's Syndrome;Dynamin;Elasticity;Endocrine;Endocrine system;Endocrine System Diseases;Epilepsy;Evolution;Exocytosis;Fragile X Syndrome;Hormones;Human;human stem cells;Impairment;innovation;insight;Integral Membrane Protein;Laboratories;Learning;Learning Disorders;Lipid Bilayers;Liquid substance;Measurement;Medical;Mental disorders;Methods;Molecular;Monitor;Nerve;Nervous System;Nervous System Disorder;neuroligin 1;Neurons;Neurotransmitters;novel;Parkinson Disease;Permeability;Physiological;postsynaptic;presynaptic;Process;Proteins;recruit;Research;response;Role;Running;sensor;sensory input;Sensory Process;Signal Transduction;Signaling Molecule;SNAP receptor;stargazin;Synapses;Synaptic plasticity;Synaptic Transmission;Synaptophysin;synaptotagmin;System;Transmembrane Domain;Tuberous Sclerosis;Vesicle;virtual;Work

PROJECT_TITLE: Fusion pores in endocrine and synaptic exocytosis


ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Narrative Plasminogen activation, MMPs, and extracellular proteolysis are rapidly advancing research areas as they intersect with basic science and clinical research. Critical roles for extracellular proteases are identified in many disorders related to cardiovascular disease, stroke and neurological disorders, aging, cancer, musculoskeletal and metabolic diseases, as well as infectious diseases. It is increasingly evident that research in this area is critical for the development of novel strategies and agents to treat these diseases.

PI_NAMEs: ZHANG, LI  (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Achievement;Aging;Alteplase;Area;Basic Science;Biology;Blood Vessels;Cardiovascular Diseases;Cardiovascular Physiology;career;Central Nervous System;cerebrovascular;Cerebrovascular Disorders;Circulation;Clinical;Clinical Research;clinically relevant;Coagulation Process;Collaborations;Communicable Diseases;Communities;Cryoelectron Microscopy;Data;Development;Diagnosis;Disabled Persons;Disease;Educational process of instructing;Ensure;Environment;Equity;equity, diversity, and inclusion;expectation;experience;extracellular;Fostering;frontier;Functional disorder;Funding;Genomics;Goals;graduate student;Growth;Homeostasis;human disease;Image;Immunity;improved;Individual;Infection;International;Investigation;Ischemic Stroke;Knowledge;Location;Malignant Neoplasms;Matrix Metalloproteinases;meetings;Metabolic Diseases;Metabolism;Metalloproteases;metaproteomics;mid-career faculty;Musculoskeletal Diseases;Musculoskeletal System;Natural regeneration;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;new technology;novel strategies;Obesity;Organ;Outcome;Participant;Pathologic;Pathologic Processes;Pathway interactions;peer;peer networks;Peptide Hydrolases;Persons;Physicians;Physiological Processes;Plasmin;Plasminogen;Plasminogen Activator;Play;Postdoctoral Fellow;pre-doctoral;Prevention;Process;Productivity;Proteins;Proteolysis;Recombinants;Research;Research Personnel;Role;Scientist;stem cell biology;Stroke;symposium;System;Technology;Therapeutic;therapeutic target;Thrombosis;Tissues;Translating;Trauma;Tumor Biology;Underrepresented Minority;Underrepresented Populations;Woman;Women's Group;Work

PROJECT_TITLE: 2024 Plasminogen Activation and Extracellular Proteolysis Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-G (O3)]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Prevention

ORG_CITY: SILVERTHORNE

ORG_NAME: KEYSTONE SYMPOSIA

PHR: PROJECT NARRATIVE Cardiometabolic diseases, such as cardiovascular disease, diabetes, obesity, and fatty liver disease, are considered the leading preventable causes of death in most geographies around the world. However, the origin, clinical presentation, and pathogenesis of these cardiometabolic diseases greatly varies worldwide, as do the resources and strategies needed to prevent and treat them. This Keystone Symposia conference will bring together scientists from all over the globe to discuss the latest in precision medicine, develop new scientific collaborations and discuss ways to implement precision medicine approaches to better understand and treat cardiometabolic disease.

PI_NAMEs: SHEPPARD, TERRY L. (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Address;Affect;Algorithms;Area;British Columbia;Canada;Cardiometabolic Disease;Cardiovascular Diseases;Cardiovascular system;career development;Cause of Death;Clinical;clinical practice;Collaborations;Communities;Data;Development;Diabetes Mellitus;Diagnostic;Disease;Disease Progression;disorder prevention;Ecosystem;Educational workshop;Environment;ethnic diversity;Ethnic Population;European ancestry;Evolution;Failure;fatty liver disease;Genetic Variation;Geography;global health;health inequalities;improved;Income;Infrastructure;insight;International;Joints;Knowledge;Learning;Link;Medicine;meetings;member;Metabolism;Methodology;Monitor;multidimensional data;multidisciplinary;Obesity;Outcome;Participant;Pathogenesis;Persons;Population;Population Research;posters;precision medicine;Predisposition;prevent;Primary Prevention;Prognosis;programs;Research;research and development;Research Personnel;Resources;Risk;Role;Scientist;Societies;stem;symposium;treatment response;Western World;Work

PROJECT_TITLE: Cardiometabolic Diseases: The Role of Ethnic Diversity in Precision Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (O3)]


NIH_SPENDING_CATS: Aging

ORG_CITY: Grandville

ORG_NAME: AMERICAN AGING ASSOCIATION, INC.

PHR: Project narrative The annual meeting of the American Aging Association (AGE) is one of the leading annual conferences in aging research in the US, and advances AGE’s mission of promoting biomedical research towards increasing the functional life span of humans, increasing knowledge of biogerontology among the public and among health professionals, and fostering the career development of trainees and scientific members. The goal of the annual AGE meeting is to convene senior and junior scientists to discuss the latest discoveries in aging research, highlight new directions in the field, and promote the emergence of new ideas and collaborative activities among participants. We seek funding for the 52nd annual AGE meeting, where approximately 63% of all invited session speakers will be early career investigators or trainees, more than half will be women, and we will highlight participation from underrepresented minority groups.

PI_NAMEs: LAMMING, DUDLEY WILLIAM (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Aging;aging mechanism;aging process;aging related;American;Awareness;Basic Science;biogerontology;Biology of Aging;Biomedical Research;career;Career Choice;career development;Career Mobility;Clinical Research;Collaborations;Communication;Communities;Data;Day Care;Dedications;Discipline;Ensure;experience;Face;Female;Fostering;Funding;Gender;General Population;Geroscience;Goals;Guidelines;Health Professional;Human;Hybrids;innovation;Knowledge;Leadership;lectures;Life;life span;live stream;Medical;meetings;member;Minority Groups;Mission;National Institute on Aging;next generation;novel strategies;Oral;outreach;parity;Participant;Persons;Postdoctoral Fellow;posters;Program Development;programs;Research;Research Personnel;Science;Scientific Societies;Scientist;Shock;Social Network;Societies;Stream;Students;symposium;Therapeutic Intervention;Translating;Underrepresented Minority;Underrepresented Populations;United States;United States National Institutes of Health;virtual;Wisconsin;Woman

PROJECT_TITLE: 52nd Annual Meeting of the American Aging Association: Integrative Approaches to Geroscience

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Research to understand and prevent cognitive decline in older populations has major public health significance. This conference will promote the use of advanced psychometric and statistical methods, and will train new and experienced researchers in the application of these methods to understanding cognitive aging.

PI_NAMEs: GROSS, ALDEN L. (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;aging related disease;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;analytical method;Applications Grants;Area;Biological Markers;career;Characteristics;Clinical;clinical practice;Clinical Research;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive testing;Collaborations;Data;Data Analyses;Data Set;Dementia;design;Diagnosis;Discipline;Disease;disease diagnosis;Education;educational atmosphere;Educational Status;Educational workshop;Elderly;ethnic disparity;Ethnic Origin;experience;Exposure to;Faculty;Funding;Gender;Goals;graduate student;Grant;Health;Image;Impaired cognition;improved;informant;innovation;interest;Journals;Manuscripts;Measurement;Measures;meetings;Mentors;Methodology;Methods;Modeling;Modernization;Monitor;next generation;older adult;Older Population;Outcome;pandemic disease;Participant;Pathologic;Peer Review;Personal Satisfaction;Play;Population;Postdoctoral Fellow;Prevalence;prevent;Productivity;programs;Psychometrics;Public Health;Publications;Race;racial disparity;Reporting;Research;Research Methodology;Research Personnel;response;Risk;Role;Science;Scientific Advances and Accomplishments;Scientist;Seasons;Series;Shapes;Statistical Methods;Statistical Models;statistics;symposium;synthetic data;Techniques;Testing;theories;Training;treatment response

PROJECT_TITLE: Conference on Advanced Psychometric Methods in Cognitive Aging Research


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE Histiocytic disorders, or histiocytoses, are a group of rare hematologic neoplasms and inflammatory disorders affecting both adults and children, characterized by accumulation of macrophage, dendritic cell, or monocyte- derived cells in affected tissues. Despite important advances in the understanding and therapy of these disorders, there are critical knowledge gaps about the natural history of the histiocytoses and their optimal treatment, in part owing to a lack of harmonized investigation across the diseases. This proposed collaborative workshop represents an unprecedented gathering of diverse senior and junior scientists, across the spectrum of histiocytic disorders, to align priorities and approaches to rigorous patient-centered research in these diseases.

PI_NAMEs: ALLEN, CARL E;DIAMOND, ELI LOUS;RODRIGUEZ-GALINDO, CARLOS  (contact)

PROGRAM_OFFICER_NAME: SID, ERIC WK

PROJECT_TERMS: Address;Adolescent;Adult;Adult Xanthogranuloma;Advocate;Affect;American;Award;Biological Markers;biomedical referral center;BRAF gene;career development;Caring;Cells;Child;Childhood;Clinical;Clinical Research;Clinical Trials;Collaborations;Communities;community engagement;CSF1R gene;Data Element;Defect;Dendritic Cells;design;Disease;disease natural history;disorder subtype;diversity and inclusion;Educational workshop;Electronic Mail;Ensure;Eosinophilic Granuloma;Erdheim-Chester Disease;Event;Family;Funding;Future;Goals;Granulomatous disease;health disparity;Hematologic Neoplasms;Hematological Disease;Hemophagocytic Lymphohistiocytoses;histiocyte;Histiocytosis;Immune;immune activation;immune function;improved;Infection;Inflammation;Inflammatory;Infrastructure;Inherited;inhibitor;inhibitor therapy;International;Investigation;kinase inhibitor;Knowledge;lectures;Lesion;Macrophage;Macrophage activation syndrome;Malignant Neoplasms;MAP2K1 gene;Mediating;meetings;Mitogen-Activated Protein Kinases;Modality;monocyte;Mutation;Natural History;Neoplasms;Observational Study;optimal treatments;Oral;Pathway interactions;patient engagement;patient oriented;Patient Outcomes Assessments;Patients;Persons;Phosphotransferases;Prevalence;Protein Isoforms;Rare Diseases;Recurrence;Research;Research Personnel;Research Priority;response;Saint Jude Children's Research Hospital;Science;Scientific Societies;Scientist;Signal Pathway;Sinus histiocytosis;social media;Somatic Mutation;Syndrome;systemic inflammatory response;Teacher Professional Development;Therapeutic;Therapeutic Studies;Therapeutic Trials;Tissues;United States;United States National Institutes of Health;Vision

PROJECT_TITLE: Defining Clinical Research Priorities and Strengthening Diversity and Patient-Stakeholder Engagement in Histiocytic Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CG-4 (02)]


NIH_SPENDING_CATS: Aging;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Lung;Lymphatic Research;Lymphedema;Neurosciences

PHR: PROJECT NARRATIVE Lymphatic vessels are important for the normal function of every organ system and for many physiological processes. This conference will present novel insights into the role of lymphatics in diseases of different organ systems including heart disease, plaque deposition in the arteries, lung inflammation, autoimmune diseases, Crohn’s disease, Alzheimer disease and cancer. Progress in understanding and treatment of lymphatic malformations and lymphedema will also be discussed.

PI_NAMEs: CHEN, HONG  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Alzheimer's Disease;Area;Arterial Fatty Streak;Arteries;Atherosclerosis;Autoimmune Diseases;Basic Science;Biological Process;Biology;Biomechanics;Blood;Blood Vessels;Body System;Bone Development;Brain;Cardiovascular Diseases;Cardiovascular system;career;career development;Cells;Clinical;clinical application;Collaborations;Communities;Congestive Heart Failure;Creativeness;Crohn's disease;Data;Dedications;Deposition;design;Development;Diagnosis;disabled;Discipline;Disease;Ensure;Equity;equity, diversity, and inclusion;Evolution;experience;Eye;Fertilization;Fostering;frontier;Functional disorder;Future;gastrointestinal system;Genetic;Goals;Growth;Growth Factor;Heart;Heart Diseases;Heterogeneity;Historically Black Colleges and Universities;Homeostasis;Hour;Hypertension;Image;Immune response;Immune system;Immunology;improved;Inflammation;insight;Interdisciplinary Study;Intestines;Kidney;Knowledge;knowledge integration;lacteal;Learning;lipid metabolism;Liquid substance;Low income;Lung;Lung Diseases;Lymphangiogenesis;Lymphatic;Lymphatic Diseases;Lymphatic Endothelium;lymphatic malformations;Lymphatic Research;Lymphatic System;lymphatic vasculature;lymphatic vessel;Lymphedema;Malignant Neoplasms;meetings;Metabolic;Metabolism;minority scientist;Mission;Molecular;Molecular Target;Myocardial Infarction;Myocardial Ischemia;National Heart, Lung, and Blood Institute;Natural regeneration;Nervous System;Neurobiology;Neurodegenerative Disorders;novel;Oral;Organ Specificity;Pathology;Patients;Physiological Processes;posters;postnatal;Prevention;primary lymphedema;Puerto Rico;Pulmonary Inflammation;Race;racial bias;Regulation;Research;Research Personnel;Role;Science;Scientist;secondary lymphedema;Sex Bias;shift work;Structure;Structure of sinus venosus of sclera;symposium;System;Thinking;Tissues;Travel;Underrepresented Minority;United States National Institutes of Health;Universities;Vascular Diseases;Vascular System;Woman;Work

PROJECT_TITLE: 2024 Lymphatics Gordon Research Conference and Seminar


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: PROJECT NARRATIVE Advances in our understanding of stem cell biology, combined with techniques for engineering diverse cell types with useful and controllable properties, are central to the field of regenerative medicine. This Keystone Symposia conference brings together an interdisciplinary group of researchers from academia and industry to advance the frontiers of research on rejuvenation of tissues and organ systems, with an emphasis on cellular engineering approaches and applications in gene therapy.

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Academia;Acceleration;Basic Science;biological systems;Biology;Body System;career development;Cell Therapy;cell type;Cells;cellular engineering;clinical implementation;clinical translation;Collaborations;Community Networks;COVID-19 pandemic;Deterioration;Educational workshop;Emerging Technologies;endogenous stem cells;engineered stem cells;Engineering;Environment;Fostering;frontier;gene therapy;Government;Hematopoietic stem cells;human disease;in vivo;Industry;industry partner;innovation;insight;interest;Joints;Knowledge;Learning;Maintenance;meetings;Mentorship;Molecular;multidisciplinary;Natural regeneration;New Mexico;Organ;Outcome;Persons;Physiological;Postdoctoral Fellow;posters;Process;programs;Property;Recurrence;regenerative approach;Regenerative Medicine;Regenerative pathway;Rejuvenation;repaired;Research;Research Personnel;Retina;Role;Running;Scientist;stem cell biology;stem cell population;Stem Cell Research;stem cell self renewal;stem cells;Students;supportive environment;symposium;Techniques;Therapeutic;Tissue Engineering;tissue regeneration;tissue stem cells;Tissues;Vascular System

PROJECT_TITLE: Stem Cells and Regeneration


ORG_CITY: GERMANTOWN

ORG_NAME: NORTH AMERICAN VASCULAR BIOLOGY ORG

PHR: Vascular Biology 2024 Annual Meeting of the North American Vascular Biology Organization  with guest society: Microcirculatory Society  October 20-2419, 2024  Asilomar Conference Grounds, Pacific Grove, California  Principal Investigator: Ying Zheng Project Narrative: At this vascular biology meeting, scientists will present new discoveries in developmental vascular biology, microcirculation, matrix biology, bioengineering, vascular genetics, vascular signaling, and inflammation and will openly discuss the impact of their findings on development, health, and disease. The integrated topics and participation by the Microcirculatory Society will facilitate interactions between established researchers and trainees with overarching common interests, who might otherwise not have opportunities for direct interaction and scientific exchange. Moreover, the conference will provide a forum for dialogue between basic and clinical/translational researchers, thereby stimulating discussions and innovations about how to optimize therapeutic approaches for the treatment of vascular pathologies.

PI_NAMEs: ZHENG, YING  (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Academia;Address;Amber;American;Aneurysm;Area;Atherosclerosis;Award;Basic Science;Biology;Biomedical Engineering;Blood flow;Blood Vessels;California;career;Cerebrum;Circulation;Clinical;Collaborations;Collection;COVID-19;design;Development;Developmental Biology;Developmental Process;Diabetes Mellitus;Disease;disease model;Disease Progression;Ensure;Environment;Ethnic Origin;experience;Face;Faculty;Female;Fertilization;field study;Fostering;Genetic;Government;graduate student;Health;Heart failure;Human;human disease;Hypertension;Individual;Industry;Inflammation;Inflammatory;innovation;interest;International;Investigation;Knowledge;lectures;malformation;Malignant Neoplasms;mechanotransduction;Medical center;medical schools;meetings;Metabolism;Microcirculation;Mission;Molecular;Morphology;nano;National Heart, Lung, and Blood Institute;Nervous System Disorder;new technology;next generation;novel therapeutics;Organ;Participant;Pathologic;Pathology;Pattern;Pennsylvania;Physiological;Physiology;Postdoctoral Fellow;posters;Pregnancy;Prevention strategy;Principal Investigator;Process;programs;Race;regeneration function;Regenerative Medicine;Regulation;Research;Research Personnel;Scientist;sex;Signal Transduction;Societies;Stroke;Structure;success;symposium;technology development;Texas;Therapeutic;therapeutically effective;tissue regeneration;Translational Research;translational scientist;Translations;Underrepresented Populations;Universities;unpublished works;Variant;Vascular Diseases;Virus Diseases;Voice;voice recognition;Washington;Woman

PROJECT_TITLE: Vascular Biology 2024 - Annual Meeting of the North American Vascular Biology Organization


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: KINGSVILLE

ORG_NAME: TEXAS A&M UNIVERSITY-KINGSVILLE

ORG_STATE: TX

PHR: Project Narrative The National Institutes of Health (NIH) Office of Research Infrastructure (ORIP) supports novel research that improves and protects human health by awarding grants to support research resources, such as animal models for human disease and state-of-the-art biomedical instrumentation. This grant will fund three conferences over five years to bring together the Directors of Resource Centers supported by NIH/ORIP, Division of Program Coordination, Planning, and Strategic Initiatives. The conferences’ objectives are to provide a setting for Directors to discuss common issues and problems pertinent to accomplishing the mission of ORIP, obtain feedback and advice from NIH staff and scientists, and share ideas for common solutions.

PI_NAMEs: SANCHEZ, ELDA E. (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Address;Animal Model;Animals;Area;Award;Biocompatible Materials;Bioinformatics;Biomedical Research;biomedical resource;Cells;Collaborations;Communities;comparative;Dedications;Discipline;Disease;District of Columbia;drug development;drug discovery;Evolution;Face;Feedback;Fostering;Funding;Future;Genetic;Goals;Grant;Health;Human;human disease;improved;Infrastructure;innovation;instrumentation;interdisciplinary approach;International;Medical;Medical Research;Medicine;meetings;Mission;Modeling;Molecular Probes;novel;Organ;Outcome;Participant;Persons;Play;posters;programs;Research;research and development;Research Infrastructure;Research Institute;Research Personnel;Research Support;Resources;Role;Science;Scientist;Site;symposium;Therapeutic;Tissues;tool;Training;United States National Institutes of Health

PROJECT_TITLE: NIH Comparative Medicine Resource Director's Meetings

STUDY_SECTION_NAME: Special Emphasis Panel[ZOD1 IMST-R (90)]


NIH_SPENDING_CATS: Cancer;Genetics;Women's Health Research

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: The PARP Family and ADP-ribosylation Project Narrative ADP-ribosylation is unique among post-translational modifications because it contains both nucleic acid and sugar features. ADP-ribosylation is catalyzed by a family of enzymes (17 in humans) known as PARPs. PARP- mediated ADP-ribosylation has widespread roles in fundamental cellular processes: from DNA repair and transcriptional regulation to the regulation of protein stability and mRNA translational regulation. PARPs are clinically relevant, and small molecule inhibitors are sought-after drug targets. Currently, there are several FDA-approved inhibitors of the founding member PARP1, which have demonstrated tremendous clinical success in the treatment of certain forms of ovarian and breast cancer. In recent years other, lesser-studied PARP family members (e.g. PARP7 and PARP14) as well as enzymes that recognize and reverse ADP- ribosylation, have emerged as exciting new therapeutic targets for cancer and inflammatory diseases. Transformative new tools developed in the last couple of years have revealed new functions for PARPs and ADP-ribosylation, and have expanded the field in exciting new directions.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Academia;Address;Adenosine Diphosphate Ribose;ADP ribosylation;Aging;Area;Basic Science;Biochemistry;biological adaptation to stress;biological systems;Biology;cancer therapy;career;career development;cell growth regulation;Cell Nucleus;Cell Physiology;Cellular biology;Chemicals;Chemistry;Circadian Rhythms;Clinical;clinical development;Clinical Research;clinically relevant;Collaborations;Communicable Diseases;Curiosities;Discipline;Disease;Disease-Free Survival;Distant;DNA;DNA Damage;DNA Repair;Drug Targeting;Educational workshop;Ensure;Environment;Enzymes;Equilibrium;equity, diversity, and inclusion;Exclusion;Faculty;Family;Family member;FDA approved;Fees;Fostering;Functional disorder;fundamental research;Funding;Future;genome integrity;Goals;graduate student;Grant;Health;hormonal signals;Human;Immune signaling;improved;Industry;Inflammation;Inflammatory;inhibitor;Knowledge;Laboratories;laboratory facility;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;meetings;member;Metabolic Diseases;Metabolism;Methodology;Minority;Molecular;Molecular Biology;Mono(ADP-Ribose) Transferases;mRNA Translation;new technology;new therapeutic target;Nicotinamide adenine dinucleotide;novel therapeutics;Nuclear Protein;Nucleic Acids;Oral;Persons;Physiology;Play;Poly(ADP-ribose) Polymerase Inhibitor;Post-Translational Protein Processing;Post-Translational Regulation;Postdoctoral Fellow;posters;posttranscriptional;programs;protein degradation;Proteins;Regulation;Research;Research Personnel;response;RNA;Role;Science;Scientist;Series;Signal Transduction;small molecule inhibitor;structural biology;Students;success;sugar;symposium;technology development;Therapeutic;therapeutic development;therapeutic target;tool;Transcriptional Regulation;Translating;Translational Regulation;Translational Research;Validation;Vision;Woman;Work

PROJECT_TITLE: CSHL 2024 Conference on the PARP Family & ADP-Ribosylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (O1)]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Genomic and phenotypic data from our closest human relatives, Neanderthals and Denisovans (archaic humans), is becoming ever more accessible due to technological advancements, but the relationship of specific genetic changes between human lineages and their downstream phenotypic effects is still unmapped. I propose to use modern, high-throughput functional genomics techniques to dissect how lineage-specific variants in cis-regulatory regions led to the emergence of unique phenotypes in both archaic and modern humans. The proposed study will be the most thorough investigation to-date of how lineage-specific derived variants have played a role in the evolution of recent human groups.

PI_NAMEs: EASTERLIN, RYDER  (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Adipocytes;Affect;Alleles;Amino Acid Substitution;Anatomy;Automobile Driving;Biological Assay;Body System;Brain;Catalogs;cell motility;cell type;Cells;Chromatin;Computer Analysis;CRISPR/Cas technology;Data;Development;differential expression;Enhancers;Environment;Event;Evolution;experimental study;Fibroblasts;functional genomics;Future;Gene Expression;Genes;Genetic;Genetic Variation;Genome;genomic data;high throughput screening;Hominidae;Human;Human Genetics;Human Genome;human induced pluripotent stem cells;induced pluripotent stem cell;Investigation;Knowledge;Libraries;Link;Measures;Modeling;Modernization;Molecular;Molecular Conformation;Morphology;Motility;Mutation;nerve stem cell;neurodevelopment;Neurons;novel;Nucleic Acid Regulatory Sequences;Nucleotides;Organoids;Osteoblasts;Pathway interactions;Phenotype;phenotypic data;Physiological Adaptation;Play;Population;pressure;prime editing;promoter;Regulation;Regulatory Element;Reporter;Role;sample fixation;Shapes;Single Nucleotide Polymorphism;single-cell RNA sequencing;Skin;Structure;Techniques;Technology;Testing;Time;trait;Transcription Initiation Site;Untranslated RNA;Variant;Work

PROJECT_TITLE: The cis-regulatory basis of lineage-specific phenotypes among human groups

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Disability Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  The Association for Research in Otolaryngology (ARO) is requesting continued support from of an NIDCD Conference Grant for its annual Midwinter Research Meeting (MWM). Support will go to funding travel for invited non-member speakers and Travel Awards for pre- and post-doctoral minority scientists, residents and medical students, and graduate students and postdoctoral fellows. In addition, the NIDCD Conference Grant would continue to enhance accessibility of the MWM for individuals with disabilities, particularly those with hearing impairments.

PI_NAMEs: LYSAKOWSKI, ANNA  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Address;Area;Award;Basic Science;Clinical Research;cost;Disabled Persons;Education;Educational workshop;Funding;graduate student;Grant;Growth;Growth and Development function;hearing impairment;Individual;interest;Medical Students;meetings;member;Minority;minority scientist;National Institute on Deafness and Other Communication Disorders;novel;Otolaryngology;Participant;Postdoctoral Fellow;posters;pre-doctoral;prospective;Research;Research Personnel;Science;Scientist;success;symposium;Travel;Work

PROJECT_TITLE: Symposia for Association for Research in Otolaryngology

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (31)]


NIH_SPENDING_CATS: Cardiovascular;Hematology

ORG_CITY: CHAPEL HILL

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Narrative Basic science and clinical research into blood coagulation proteins and platelets is critical as bleeding and thrombotic disease remain the leading causes of death worldwide. Moreover, recent advances have identified important roles for clotting proteins and platelets in many pathological processes beyond bleeding and cardiovascular disorders, including cancer, aging, and infectious diseases. The 11th Symposium on Hemostasis provides an ideal setting and opportunity for scientists and clinicians to share their latest advances, as well as to welcome trainees into this exciting field of study.

PI_NAMEs: FLICK, MATTHEW J. (contact)

PROJECT_TERMS: Aging;Anticoagulants;Antiplatelet Drugs;Area;Basic Science;Biology;Blood coagulation;Blood Coagulation Disorders;Blood Platelets;Cardiovascular Diseases;career;Cause of Death;Cells;Clinical;Clinical Management;clinical practice;Clinical Research;clinically relevant;Coagulation Process;Collaborations;Communicable Diseases;Communities;cost;Data;Dedications;design;Development;Diagnosis;Disease;Ensure;Environment;Equity;expectation;Fees;Fibrinogen;field study;frontier;Funding;gene therapy;Goals;graduate student;Growth;Health;Hematology;Hemophilia A;Hemorrhage;Hemostatic Agents;Hemostatic function;Human;Immunity;Individual;Infection;innovation;International;Ischemic Stroke;Knowledge;Malignant Neoplasms;Medical Students;meetings;Natural regeneration;new technology;North Carolina;novel;Oral;Participant;Pathogenesis;Pathologic;Pathologic Processes;peer networks;Peptide Hydrolases;Persons;Physiological;Physiological Processes;platelet function;Play;Postdoctoral Fellow;posters;pre-doctoral;Process;programs;protein function;Proteins;recruit;Research;Research Personnel;Role;Scientist;Sickle Cell Anemia;Stroke;Structure;symposium;Technology;Therapeutic;Thrombosis;Tissues;Translations;Travel;Underrepresented Minority;Underrepresented Populations;Universities;Woman;Women's Group;Work;Xenograft procedure

PROJECT_TITLE: 11th Symposium on Hemostasis at University of North Carolina at Chapel Hill


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: PROJECT NARRATIVE Environmental injustice contributes to disparities in health status across populations of differing ethnicity, race, and socioeconomic status. Infants and children, because of their unique biological vulnerabilities and age‐related patterns of exposure, are especially vulnerable to the health impacts of environmental injustice. This initial conference of a five year series will bring together child exposomics researchers with students and early stage investigators from historically black colleges and universities with community and child health advocates to assess the state of the science and create an environmental justice agenda for children.

PI_NAMEs: JUAREZ, PAUL D (contact);WRIGHT, ROBERT O

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Adolescence;Adult;Advocate;Age;age related;Applications Grants;Artificial Intelligence;Asthma;Behavior;Biological;Biology;Brain;built environment;career;Characteristics;Child;Child Development;Child Health;Childhood;Communities;Community Health;community partners;Development;Diabetes Mellitus;Differentiation and Growth;Disease Outcome;disenfranchised population;Disparity;disparity reduction;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Environmental Health;Environmental Impact;environmental justice;Ethnic Origin;experience;Fostering;Genes;Goals;Government;Growth;Hand;Health;health disparity;health equity;health inequalities;Health Status;Historically Black Colleges and Universities;improved;Incidence;Individual;Inequity;Infant;Intervention;Lead;Lead Poisoning;lens;Life;Life Cycle Stages;Machine Learning;Malignant neoplasm of lung;Measures;medical schools;Mental Health;Mentorship;middle age;Minority Groups;Minority-Serving Institution;multidimensional data;neurobehavior;Neurocognition;Neurons;Obesity;older adult;Oral cavity;Outcome;Pathway interactions;Pattern;Persons;Poison;Policies;Population;population health;Predisposition;Pregnancy;Prevalence;Prevention;Process;prospective;Race;rapid growth;recruit;Research;Research Personnel;Science;Scientist;Series;Shapes;Social Environment;social health determinants;Socioeconomic Status;stressor;Students;symposium;Synapses;synaptic pruning;Time;Toxicant exposure;Training;Underrepresented Minority;young adult

PROJECT_TITLE: Exposome and Health Equity Conference Series across the Life Course

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 ARL-W (13)]


ORG_CITY: CARLSBAD

ORG_NAME: ACTIVE MOTIF, INC.

PHR: We propose a robust, scalable, and cost-effective assay to quantitate epigenetic changes following partial reprogramming - microscopic imaging of Epigenetic Age (miEpiAge).

PI_NAMEs: EGAN, BRIAN STANLEY;JELINEK, MARY ANNE (contact);TERSKIKH, ALEXEY V

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: Abbreviations;Academia;Acetylation;Age;age acceleration;age related changes;Aging;Animals;ATAC-seq;biological age;Biological Assay;Biological Clocks;Blood;c-myc Genes;Calibration;Caloric Restriction;CD3 Antigens;cell type;Cells;chemotherapy;Chromatin;Chronology;commercialization;cost;cost effective;Custom;data integration;Data Set;Dependence;Detection;dietary restriction;DNA Methylation;Doxorubicin;Epigenetic age;epigenetic clock;Epigenetic Process;epigenome;experimental study;genome analysis;genome sequencing;genome-wide;Hepatocyte;Heterogeneity;histone methylation;Human;Image;in vivo;inducible gene expression;Industry;interest;Intervention;Laboratories;Linear Regressions;Liver;Machine Learning;Maps;Marketing;Methods;Methylation;microscopic imaging;Microscopy;Monitor;Mus;novel;Nuclear;old mice;Organ;Pattern;Peripheral Blood Mononuclear Cell;Phase;Rejuvenation;Reporting;Sampling;Services;single cell analysis;Site;Spleen;Stains;Techniques;Teratoma;Therapeutic;Time;Tissues;tool;Training;Transgenic Mice;Uncertainty;Validation;whole genome

PROJECT_TITLE: Novel Integrated Platform to Quantitate Rejuvenation in vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (15)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PHR: Project Narrative Immunoengineering is a young and vibrant field that seeks to improve human health via cutting-edge analysis, manipulation, and engineering of the immune system, yielding, for example, the cancer immunotherapies that were named the 2013 Breakthrough of the Year by Science Magazine. Following on the tremendous success of the inaugural meeting in 2022, this 2024 Immunoengineering GRC and GRS for will bring together basic scientists, engineers, and translational experts to brainstorm new ideas across disparate fields catalyze new approaches to improve human health that can be realized in the clinic. The meeting will also advance the future of the field by supporting the careers of trainees and young investigators in Immunoengineering, and by actively promoting diversity and inclusion in the program and attendances.

PI_NAMEs: THOMAS, SUSAN NAPIER (contact)

PROGRAM_OFFICER_NAME: BARTELS, ADELINA EWURA-ABENA

PROJECT_TERMS: 2019-nCoV;Academia;Acceleration;Address;Advertising;Aging;Autoimmunity;base;Biocompatible Materials;Bispecific Antibodies;cancer immunotherapy;cancer therapy;career;Career Mobility;Cell Physiology;Cells;Cellular immunotherapy;chimeric antigen receptor T cells;Clinic;Clinical;clinical care;Collaborations;Communities;design;Discipline;Disease Progression;Disparate;diversity and inclusion;Ebola;Educational workshop;Engineering;Ensure;Equity;equity, diversity, and inclusion;Event;fighting;Fostering;Foundations;Funding;Future;Generations;global health;Health;Heart Diseases;Human;Hypersensitivity;Immune;Immune response;Immunity;immunoengineering;Immunologics;Immunologist;Immunology;immunoregulation;Immunotherapy;improved;in vitro Model;Individual;Industry;Infection;innovation;interdisciplinary approach;interdisciplinary collaboration;International;Italy;Journals;Knowledge;Leadership;Malignant Neoplasms;meetings;Mentors;Molecular;Names;Nature;Nerve Degeneration;neuroimmunology;neuroinflammation;novel strategies;novel vaccines;Nucleic Acids;pathogen;peer;peer coaching;physical science;Positioning Attribute;posters;prevent;professor;programs;Regenerative Medicine;Request for Proposals;Research;Research Personnel;RNA vaccine;Science;Scientist;Series;success;Suggestion;support network;symposium;System;Technology;Testing;Therapeutic;Time;translational impact;Translations;Underrepresented Minority;Universities;Vaccines;Vocational Guidance;Woman;Work

PROJECT_TITLE: 2024 Immunoengineering Gordon Research Conference & Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 BJM-D (S2)]