NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: KIPPS, THOMAS J (contact)

PROJECT_TERMS: Animal Experiments;anti-cancer research;Apoptosis;Bar Codes;Biological Assay;Biomedical Research;Cancer Center;Cancer Center Support Grant;Capital;cell analyzer;Cell Culture Techniques;Cell Cycle;Cell Proliferation;Cell Separation;Cells;Clinical;Clone Cells;Color;Communities;Compensation;Consult;Consultations;Core Facility;cost;cost efficient;cytokine;Cytometry;Data;data acquisition;Data Analyses;Dedications;Deposition;Detection;Development;Dissociation;Education;Electronic Mail;Ensure;Experimental Designs;Flow Cytometry;Flow Cytometry Shared Resource;Fluorescence;Funding;Growth Factor;Hour;Human Resources;Immunophenotyping;Individual;Institution;instrument;instrumentation;Lasers;Link;Measures;Mediation;Medical;Mission;Monitor;NCI Center for Cancer Research;new technology;Online Systems;operation;Peer Review;Population;Productivity;programs;protein expression;Protocols documentation;Publications;Research;Research Personnel;Reservations;Resource Sharing;Resources;Sampling;Schedule;Services;Signal Transduction;single cell analysis;Sorting;Speed;Stains;System;Technical Expertise;Time;tool;Training;Training and Education;transcription factor;Tube;Universities;Validation;web page;web site;Work

PROJECT_TITLE: Flow Cytometry Shared Resource


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PI_NAMEs: HALL, DAVID J (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: 3-Dimensional;Animals;anti-cancer research;Behavior;California;cancer cell;Cancer Center;Cancer Center Support Grant;cancer therapy;Cells;Collaborations;Complex;Conceptions;Consultations;Core Facility;Data Analyses;Dedications;Disease Progression;Drug Delivery Systems;Electron Microscope;Equipment;Fluorescence;Fluorescence Resonance Energy Transfer;Fluorescent Probes;Fostering;Gene Expression Profile;Goals;Hour;Image;image processing;imaging approach;imaging system;Imaging technology;improved;in vivo imaging;Individual;instrument;instrumentation;interest;Investigation;Leadership;Malignant Neoplasms;member;Methods;Microscopy;Molecular;Neurosciences;non-invasive monitor;optical imaging;Organism;particle;Pharmacotherapy;Phase-Contrast Microscopy;photoactivation;Photobleaching;Proteins;Qualifying;Reagent;Recovery;Research;Research Personnel;Resolution;Resource Sharing;Sampling;Services;System;Techniques;tool;trafficking;Training;tumor progression;ultra high resolution;Universities

PROJECT_TITLE: Microscopy Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: MELLON, PAMELA L (contact)

PROJECT_TERMS: Acceleration;Animals;anti-cancer research;Applications Grants;Bacterial Artificial Chromosomes;Biological Models;blastocyst;Breeding;California;Cancer Center;Cancer Center Support Grant;Cancer Etiology;cancer imaging;Cancer Model;Cell Cycle Regulation;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Consult;cost effective;Cre-LoxP;Creativeness;CRISPR/Cas technology;Dedications;design;Development;Disease;DNA;drug testing;Embryo;Embryology;embryonic stem cell;Equipment;Etiology;FLP recombinase;Frequencies;Future;Genes;Genetic;genetic approach;genetic manipulation;Genetic Services;Genetic Techniques;genetic technology;Genetically Engineered Mouse;Genome;Harvest;homologous recombination;Human;human model;Human Resources;in vivo;Individual;Injections;innovation;interest;Investigation;Knock-out;Knockout Mice;Knowledge;Letters;Malignant Neoplasms;Medical;meetings;member;Methods;Microinjections;Microtus;Mission;Modification;Molecular Genetics;Mouse Embryonic Stem Cells;mouse genetics;mouse genome;mouse model;Mus;Mutagenesis;Mutation;Neoplasm Metastasis;new technology;novel;novel strategies;Oncogenes;Pathogenesis;prevent;Process;Proteins;Protocols documentation;Quality Control;recombinase-mediated cassette exchange;Research;Research Personnel;Research Project Grants;Resource Sharing;reverse genetics;RiboTag;RNA;Scheme;Services;Study models;Tamoxifen;Techniques;Technology;Testing;Tetanus Helper Peptide;Tissues;Training;Transgenes;Transgenic Mice;Transgenic Organisms;Treatment Protocols;tumor;Tumor Suppressor Genes;Universities;web site;zygote

PROJECT_TITLE: Transgenic Mouse Shared Resource


PI_NAMEs: MESSER, KAREN  (contact)

PROJECT_TERMS: Accounting;Animals;anti-cancer research;Applications Grants;Area;Basic Science;Bioinformatics;Biological Markers;Biometry;Biostatistics Core;Biostatistics Shared Resource;Blood;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Research Project;Cells;Charge;Clinical Data;Clinical Sciences;Clinical Trials;Clinical Trials Design;Collaborations;Computer software;Consult;Data;Data Analyses;data management;design;Development;Doctor of Philosophy;doctoral student;Education;Education and Outreach;Electronic Mail;Faculty;Floor;Formulation;Fostering;Funding;Future;Goals;Grant;Human;Human Resources;human subject;Image Analysis;improved;innovation;Internet;Intervention;investigator-initiated trial;Laboratories;Leadership;Longitudinal cohort;Malignant Neoplasms;Manuscripts;Medicine;member;Methodology;Mission;Monitor;Natural Language Processing;Nature;novel therapeutics;outreach;Paper;Pediatrics;Peer Review;Persons;Pilot Projects;Population Sciences;Population Study;Preparation;Productivity;programs;protocol development;Protocols documentation;Publications;Quality Control;Records;recruit;Registries;Reporting;Reproducibility;Research;Research Design;Research Personnel;Resource Sharing;Resources;Safety;Sampling;Science;Services;sound;Statistical Data Interpretation;statistics;Talents;Telephone;Therapeutic;Therapeutic Studies;Therapeutic Trials;Training;translational pipeline;Translational Research;web platform

PROJECT_TITLE: Biostatistics Shared Resource


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: FRAZER, KELLY A (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Area;Bioinformatics;Biological Markers;biomarker discovery;Cancer Center;Cancer Center Support Grant;cancer genomics;cancer initiation;ChIP-seq;Computational Biology;Computational Technique;Computer Analysis;Consultations;Core Facility;cost;cost effective;Data;data acquisition;Data Analyses;Data Set;Development;differential expression;DNA;DNA Methylation;Engineering;Environment;epigenomics;Equipment;experience;experimental analysis;Experimental Designs;Funding;Gene set enrichment analysis;Generations;Genes;Genetic Fingerprintings;genomic data;Genomic medicine;genomic profiling;Genomics;Goals;High-Throughput Nucleotide Sequencing;Immunotherapy;improved;Individual;innovation;instrumentation;Invaded;Laboratories;Libraries;member;Messenger RNA;Metagenomics;Methods;microbiome analysis;MicroRNAs;Molecular;neoantigens;Nomograms;novel strategies;Pathway Analysis;Price;Productivity;programs;Protein Isoforms;Qualifying;Research;Research Design;Research Personnel;Resource Sharing;Resources;Scientist;Services;single-cell RNA sequencing;skills;Somatic Mutation;Strategic Planning;Systems Analysis;Systems Biology;Technology;tool;Training and Education;transcriptomics;translational cancer research;translational medicine;tumor;tumor microenvironment;Variant

PROJECT_TITLE: Genomics and Computational Biology Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: MOLINOLO, ALFREDO ALBERTO (contact)

PROJECT_TERMS: Academic Training;Accreditation;AGTR2 gene;American;Animal Experiments;anti-cancer research;Antibodies;biobank;Bioinformatics;Biological;Biological Assay;Biomedical Research;Biopsy;Blood;Cancer Center;Cancer Center Support Grant;Cell Survival;Cellularity;Clinical;Clinical Research;Clinical Trials;Collaborations;Collection;college;Consent;Consultations;Core Biopsy;cost effective;Cytology;Data;Dedications;design;Development;Diagnosis;digital;digital imaging;Disease;Drug or chemical Tissue Distribution;Employment;Enrollment;Epidemiology;Equipment;Equipment and supply inventories;Excision;experience;Experimental Designs;Experimental Pathology;Formalin;Freezing;Guidelines;Health system;Histologic;Histology;Histopathology;Hour;Human;Human Pathology;human tissue;Immunofluorescence Immunologic;Immunohistochemistry;Immunophenotyping;Informed Consent;Infrastructure;Institution;Institutional Review Boards;Interview;Ischemia;Knowledge;Link;Liquid substance;Medical;member;Mission;Modeling;Molecular;multimodality;Mus;NCI-Designated Cancer Center;Necrosis;Needles;neoplastic cell;novel;Operative Surgical Procedures;Outcome;Paraffin;Pathologist;Pathology;Patient Admission;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Physicians;Plasma;Policies;Preparation;Price;Procedures;prospective;Protocols documentation;Provider;quality assurance;Reaction Time;Recording of previous events;Research Personnel;Resource Sharing;Resources;Sampling;Scanning;Serum;Services;Slide;Solid;Solid Neoplasm;Specimen;Stains;Surgeon;System;Techniques;Technology;Tissue Banks;Tissue Fixation;tissue fixing;Tissue Microarray;Tissue Preservation;tissue processing;Tissue Procurements;Tissue Sample;Tissues;Training;translational study;tumor;Tumor Bank;Validation;Whole Blood

PROJECT_TITLE: Biorepository and Tissue Technology Shared Resource


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Nutrition;Obesity;Physical Activity;Prevention

PI_NAMEs: RANA, BRINDA K (contact)

PROJECT_TERMS: Affect;anti-cancer research;Area;Behavior;Behavior assessment;Behavior Therapy;Behavioral;behavioral outcome;Behavioral Research;Behavioral Sciences;behavioral study;biobehavior;Biological;Biological Factors;Body Composition;Body Weight decreased;Cancer Center;Cancer Center Support Grant;cancer diagnosis;Cancer Prognosis;cancer risk;Categories;Clinical;Clinical Medicine;Collection;Communication;computerized data processing;Data Collection;Development;Devices;Diet;dietary;Dietary History;Discipline;DNA;enhancing factor;Ensure;Epidemiology;evidence base;exercise intervention;Faculty;Funding;Genetic;Goals;Grant;Heritability;Hour;improved;intervention effect;Intervention Studies;Investments;Journals;laboratory facility;Leadership;Life Style;Link;Malignant Neoplasms;Measurement;Measures;member;Methodology;Methods;Modality;Molecular;Monitor;new technology;Obesity;Online Systems;operation;Outcome;Overweight;Peer Review;Physical activity;Population Sciences;Preparation;Procedures;Productivity;Prognosis;programs;protocol development;Publications;Qualifying;Quality Control;Questionnaires;Research;Research Personnel;Resource Sharing;Resources;Sampling;Science;sedentary lifestyle;service intervention;Services;Shipping;Solid;study population;success;Supervision;Techniques;Technology;telephone based;therapy design;therapy development;Training;tumor progression;Venous blood sampling

PROJECT_TITLE: Biobehavioral Shared Resource


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: YANG, JING  (contact)

PROJECT_TERMS: Abnormal Cell;Affect;Animal Model;anti-cancer research;Attention;Biochemical;Biochemistry;Bioinformatics;Biological;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Detection;cancer immunotherapy;cancer initiation;Cancer Patient;cancer prevention;cancer therapy;Catchment Area;cell growth;cell growth regulation;Cell model;Cell Physiology;Cell Survival;Cells;Cellular biology;collaborative environment;Communication;Cues;Detection;Development;Diagnosis;Direct Costs;DNA sequencing;Drug Targeting;Enzymes;Funding;Future;Genes;Genetic;genetic regulatory protein;genomic data;Genomics;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;Human;Immune system;Immunity;improved;Knowledge;Liquid substance;Malignant Neoplasms;member;Metabolic;Molecular;Molecular Biology;Molecular Target;Mutation;NCI-Designated Cancer Center;Neoplasm Metastasis;Normal Cell;novel;Oncogene Activation;Oncogenes;Oncogenic;Pathway interactions;Peer Review;Phosphotransferases;Production;programs;Proliferating;Publications;Quality of life;Regulation;Reporting;Research;Research Personnel;response;Schools;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Solid;Source;structural biology;success;Technology;Therapeutic;tool;Transcription Alteration;transcription factor;treatment effect;tumor;Tumor Immunity;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;United States National Institutes of Health;Vision

PROJECT_TITLE: Cancer Biology and Signaling


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: VARNER, JUDITH A (contact)

PROJECT_TERMS: Area;Biological Markers;Brain Neoplasms;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Patient;cancer stem cell;career;Catchment Area;Clinic;Clinical;clinical application;Clinical Research;Collaborations;cytotoxic;Defect;design;Development;Diagnostic;Direct Costs;Discipline;Drug Design;drug efficacy;Emerging Technologies;Faculty;Fostering;Funding;Genome;Genomics;Geography;Goals;Head and Neck Cancer;Image;Imaging Device;Immune;Immunodiagnostics;Immunooncology;Immunotherapy;improved;Interdisciplinary Study;interest;Investigational Therapies;investigator-initiated trial;Malignant Neoplasms;member;Metabolic;metabolomics;Mission;Molecular;NCI-Designated Cancer Center;neoplastic;neoplastic cell;new technology;Non-Hematologic Malignancy;novel;novel strategies;novel therapeutics;Patients;Peer Review;Phase;Precision therapeutics;preclinical study;Process;Productivity;programs;Proteomics;Publications;Records;Research;Research Personnel;Resistance;Resource Sharing;Role;Safety;Schools;Science;Signal Transduction;Solid Neoplasm;Source;stem cells;Strategic Planning;success;System;Technology;Therapeutic;therapeutically effective;therapy development;tool;transcriptomics;Translating;Translations;treatment strategy;tumor;Tumor Biology;tumorigenesis;United States National Institutes of Health;Vision

PROJECT_TITLE: Solid Tumor Therapeutics


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PROJECT_TERMS: Acceleration;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;adaptive immune response;ADAR1;Address;Area;biobank;Biological Assay;Biological Response Modifier Therapy;Biology;Blood;California;Cancer Center;Cancer Center Support Grant;Cancer Relapse;cancer stem cell;carcinogenesis;Catchment Area;Cell Culture Techniques;Cell Therapy;Cells;Clinic;Clinical;clinical development;Clinical Research;clinical translation;Clinical Trials;Clonal Evolution;Code;Cryopreservation;Development;diagnostic assay;Disease;Dissection;DNA;DNA Sequence Alteration;Dysmyelopoietic Syndromes;Epigenetic Process;epigenome;Erinaceidae;functional genomics;Funding;Genes;Genetic;Goals;Hematologic Neoplasms;Hematopoiesis;hip replacement arthroplasty;Hispanic Populations;Human;humanized mouse;Impairment;improved;improved outcome;inhibitor;Innate Immune Response;insight;JAK2 gene;leukemia;leukemia/lymphoma;lymphoid neoplasm;Lymphoma;Malignant lymphoid neoplasm;Malignant Neoplasms;Marrow;Medicine;member;Mission;Modeling;Molecular Target;Monoclonal Antibodies;mouse model;Multiple Myeloma;mutant;Myeloproliferative disease;nanoproteomic;neoantigens;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Peer Review;pharmacokinetics and pharmacodynamics;Phase;Phase I Clinical Trials;phase I trial;Phase II Clinical Trials;Phenotype;pre-clinical;precision medicine;Preleukemia;premalignant;prevent;professor;programs;Property;Proteomics;Publications;Regenerative Medicine;Regulation;Relapse;relapse risk;Research;Research Institute;Research Personnel;Resistance;Resource Sharing;Ribosomes;risk mitigation;RNA Editing;RNA Processing;RNA Splicing;ROR1 gene;Sampling;Schools;Scientist;self-renewal;Signal Pathway;Signal Transduction;small molecule;Somatic Mutation;Source;Spliceosomes;stem cell biology;Stem Cell Research;stem cells;Strategic Planning;Surrogate Endpoint;T cell therapy;Technology;Testing;Therapeutic Index;therapeutic target;therapy resistant;transcriptome;transcriptomics;Transgenic Organisms;Translating;Translational Research;Transplantation;Treatment Side Effects;tumor progression;United States National Institutes of Health;Untranslated RNA;whole genome

PROJECT_TITLE: Hematologic Malignancies


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Nutrition;Obesity;Physical Activity;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Women's Health Research

PI_NAMEs: GUPTA, SAMIR  (contact)

PROJECT_TERMS: Address;Adopted;Affect;Area;Asian Pacific Islander;Behavior;behavior change;Behavioral;Body Weight decreased;Breast Cancer survivor;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Control Research Program;Cancer Detection;Cancer Etiology;cancer health disparity;cancer prevention;cancer risk;Cancer Survivorship;career;Catchment Area;Clinical;Collaborations;Colorectal Cancer;community intervention;Complex;Development;Diagnosis;Diet;Dietary Intervention;Direct Costs;Disparity;dissemination science;Early Diagnosis;Elderly;Electronic cigarette;Epidemiologist;epidemiology study;Faculty;Fasting;Fostering;Funding;Future;handheld mobile device;Hispanic Populations;implementation science;improved;Incidence;innovation;innovative technologies;interest;International;Interruption;Intervention;intervention program;Intervention Studies;Joints;Leadership;Length;Life Style;lifestyle intervention;Low Income Population;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;member;Mentors;Mission;mortality;NCI-Designated Cancer Center;Neoplasms;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel strategies;Obesity associated cancer;obesity prevention;older adult;Peer Review;Peer Review Grants;Persons;Physical activity;Play;Policies;Population;premalignant;Prevalence;prevent;Prevention;Primary Prevention;programs;Publications;recruit;Recurrence;Research;Research Personnel;Resources;Risk Assessment;Risk Factors;Scientific Advances and Accomplishments;Scientist;screening;Screening for cancer;sedentary lifestyle;Source;Strategic Planning;survivorship;Technology;Testing;Tobacco use;Tobacco-Related Carcinoma;Training Activity;Training and Education;Translating;Translational Research;treatment program;Underserved Population;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Cancer Control Program


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Digestive Diseases;Genetics;Human Genome;Liver Cancer;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: MESIROV, JILL P. (contact)

PROJECT_TERMS: anti-cancer research;Area;Biological;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Etiology;cancer genetics;Cancer Model;cancer therapy;cancer type;candidate identification;Carcinogens;Catchment Area;Categories;Cell Physiology;Clinical;clinical candidate;Clinical Data;clinical decision-making;clinical phenotype;clinical translation;Collaborations;Combined Modality Therapy;Communities;Complex;Computational algorithm;Computational Biology;Computer Models;computerized tools;Computing Methodologies;Copy Number Polymorphism;Data;Data Science;Data Set;Development;Diagnosis;Direct Costs;Dissemination and Implementation;DNA;Eligibility Determination;empowerment;Environment;Epigenetic Process;extrachromosomal DNA;Fostering;functional genomics;Funding;Gene Expression;Gene Proteins;Genes;Genetic;genome-wide;genomic data;Genomics;Goals;Head and Neck Surgeon;Human;Immunologics;innovation;interest;International;Intervention;Knowledge;large scale data;Leadership;Lesion;Machine Learning;Malignant Neoplasms;medical schools;member;Metabolic;metabolomics;Methods;microbiome;Modeling;Molecular;Molecular Profiling;Multiomic Data;multiple omics;Mutation;Nature;NCI Center for Cancer Research;neoplastic cell;network models;new therapeutic target;novel;novel diagnostics;novel strategies;outcome prediction;Pathway interactions;patient stratification;Patient-Focused Outcomes;Patients;Phenotype;Positioning Attribute;Precision therapeutics;Primary carcinoma of the liver cells;Productivity;prognostic;prognostic indicator;programs;protein expression;Proteins;Proteomics;Publishing;Records;Research Peer Review;Research Personnel;Research Project Grants;Resistance;response;Role;Science;Scientist;Signal Pathway;structural genomics;targeted treatment;Therapeutic;Therapeutic Intervention;therapeutic target;tool;transcriptomics;Translating;translational cancer research;translational scientist;Translations;tumor;tumor progression;Validation;Variant;Vision

PROJECT_TITLE: Structural and Functional Genomics


NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: MARTINEZ, MARIA ELENA (contact)

PROJECT_TERMS: Address;Affect;Alaska Native;American Indians;Area;Asian Pacific Islander;Black Populations;California;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer health disparity;cancer prevention;Caring;Catchment Area;Clinical Trials;Communities;community academic partnership;community advisory board;community engagement;Community Healthcare;Community Outreach;Comprehensive Cancer Center;County;Education and Outreach;Ensure;Ethnic Population;evidence based guidelines;Evidence based practice;Federally Qualified Health Center;Funding;Future;Goals;Health Personnel;Hispanic Populations;HPV vaccine acceptance;implementation facilitation;Individual;Joints;Knowledge;Leadership;Limited English Proficiency;Location;Malignant Neoplasms;medically underserved;Mexico;Minority;Minority Groups;Neighborhood Health Center;neoplasm resource;Not Hispanic or Latino;outreach;outreach program;Policies;Population;primary care provider;Primary Prevention;Provider;racial minority;Research;Research Project Grants;screening;Shapes;Structure;survivorship;Therapeutic Trials;treatment and outcome;Underinsured;underserved community;Underserved Population;Uninsured;Universities

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention

PI_NAMEs: SIMEONE, DIANE M (contact)

PROJECT_TERMS: Area;Award;Caliber;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Patient;cancer stem cell;cancer therapy;Capital;Catchment Area;Cell Therapy;Cervical;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Colorectal;Complement;Dedications;Development;effective intervention;Faculty;Family;first-in-human;Fostering;Funding;Genomic medicine;Goals;Growth;Hematology;Hepatic;High-Risk Cancer;Immunooncology;Individual;innovation;Institution;Investments;Laboratories;Lead;Malignant Neoplasms;member;Mentors;Mission;Molecular Target;multidisciplinary;neuro-oncology;novel;novel therapeutics;Nursing Faculty;Outpatients;Peer Review;Peer Review Grants;peer support;Phase;Physicians;Pilot Projects;Population Sciences;Prevention strategy;Probability;Productivity;programs;Recommendation;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Resource Sharing;Resources;Scientist;Secure;Selection Criteria;skills;Skin;stem cell therapy;Strategic Planning;Training;Translating;Translational Research;Translations;United States National Institutes of Health;Vision

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Cancer;Prevention

PROJECT_TERMS: Advisory Committees;anti-cancer research;Area;Basic Science;Cancer Center;Cancer Center Support Grant;Cancer Patient;cancer prevention;cancer risk;cancer therapy;career;Catchment Area;Clinical;clinical care;Clinical Investigator;Clinical Research;Clinical Sciences;Collaborations;Communities;community engagement;cost effective;Decision Making;Development;Disparity;Education;education research;Environment;Evaluation;experience;Faculty;Faculty Recruitment;Fostering;Funding;Goals;Grant Review;Growth;Growth and Development function;improved;Individual;innovation;Laboratories;Leadership;Malignant Neoplasms;Medicine;meetings;Monitor;multidisciplinary;NCI Center for Cancer Research;novel;operation;Operative Surgical Procedures;organizational structure;Outcome;Pathology;Patient-Centered Care;Patient-Focused Outcomes;Play;Population Research;Population Sciences;Procedures;Process;programs;Radiation Oncology;recruit;Research;Research Infrastructure;Research Personnel;Resource Allocation;Resource Sharing;Resources;response;Review Committee;Risk;Risk Behaviors;Role;Science;Scientist;Strategic Planning;Structure;Students;success;survivorship;Toxic effect;Training Activity;Training and Education;Translating;Translational Research;Translations;treatment optimization;Vision

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety

PI_NAMEs: GOLD, KATHRYN ANN (contact)

PROJECT_TERMS: California;Cancer Center;Cancer Center Support Grant;Catchment Area;Clinical;Clinical Cancer Center;Clinical Data;Clinical Protocols;Clinical Research;Clinical Trials;Communication;data management;Education;Ensure;Ethics;Infrastructure;Malignant Neoplasms;Medical;Monitor;operation;outreach;participant enrollment;Patients;Pediatric Hospitals;Physicians;Preparation;programs;Publications;quality assurance;Records;Reporting;repository;Research;Research Personnel;research study;Resources;screening;Services;Training and Education;Universities

PROJECT_TITLE: Clinical Protocol and Data Management


PI_NAMEs: BAZHENOVA, LYUDMILA  (contact)

PROJECT_TERMS: anti-cancer research;Appointment;authority;Biometry;California;Cancer Center;Cancer Center Support Grant;cancer research center director;Clinical Cancer Center;Clinical Research;Data;Dedications;design;Diagnosis;Disease;Ensure;expedited review;Faculty;Goals;human subject;improved;Industry;Institution;Institutional Review Boards;Malignant Neoplasms;Medicine;meetings;member;Modification;Monitor;multidisciplinary;Outcome;Pediatric Hospitals;Peer Review;Population Sciences;Prevention;Procedures;Process;process improvement;professor;Protocols documentation;Regimen;Research;Research Personnel;research study;Review Committee;Risk;Safety;Screening procedure;sound;Staging;System;Universities;Work

PROJECT_TITLE: Protocol Review and Monitoring Committee


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE Although parent-involved interventions for adolescent alcohol use disorder and co-occurring disorders results in the best outcomes, our understanding of the parenting behaviors during treatment that improve outcomes remains at a nascent stage. The goal of this K99/R00 is to examine parenting practices (parental communication, general parenting practices, and alcohol-specific parenting practices), in real time in daily life, and their associations with adolescent core treatment targets (e.g., treatment motivation, alcohol craving and use) throughout evidence-based parent-involved treatment for co-occurring disorders. By identifying the parenting behaviors that most strongly relate to core treatment targets during treatment, results from this project will provide critical information to facilitate the development of brief, scalable, parent-involved interventions.

PI_NAMEs: MEISEL, SAMUEL NOAH (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: acceptability and feasibility;Address;Admission activity;Adolescent;adolescent alcohol treatment;Adolescent Behavior;adolescent substance use;adolescents with alcohol use disorders;Affect;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol craving;alcohol use disorder;Alcohols;associated symptom;behavior change;Behavioral Mechanisms;Child Rearing;Communication;Data;design;Development;Diagnosis;dual diagnosis;Ecological momentary assessment;Enrollment;evidence base;Exhibits;Faculty;Feedback;Future;Goals;Grant;improved;improved outcome;Intervention;Length;Life;marijuana use;Measures;Medicine;Mental Health;Methods;Monitor;Motivation;National Institute on Alcohol Abuse and Alcoholism;Nature;Outcome;outcome prediction;outpatient programs;Outpatients;parenting intervention;Parents;Phase;Pilot Projects;pilot test;Prediction of Response to Therapy;protocol development;Protocols documentation;Psychiatric Diagnosis;recruit;Reporting;Research;Research Personnel;research study;Risk;Sampling;Site;skills;Strategic Planning;substance use treatment;Symptoms;teenage parents;Testing;Time;Training;Treatment outcome;treatment program;treatment research;underage drinking;virtual;Youth

PROJECT_TITLE: Assessing Parenting at the Momentary Level to Understand Parenting Behaviors that Contribute to Improved Treatment Outcomes for Youth with Co-Occurring Disorders

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences;Pediatric;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Deficits in skilled reading ability contribute substantially to poor functional outcome in schizophrenia. The present study investigates both consequences and causes of impaired reading ability in schizophrenia.

PI_NAMEs: JAVITT, DANIEL C. (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Acceleration;Alcohol consumption;Assessment tool;Auditory;auditory processing;Auditory system;Behavioral;Biological Markers;Clinical;Clinical Management;Cognition;Computer Models;Contrast Sensitivity;Data;Development;Disease;Early Diagnosis;Education;eighth grade;eleventh grade;Employment;Evaluation;Event-Related Potentials;Eye Movements;Family;first episode schizophrenia;follow-up;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;functional outcomes;Future;gaze;Generations;high risk;high risk population;high school;Human Resources;imaging approach;Impaired cognition;Impairment;improved;indexing;Individual;information processing;Intervention;Intervention Studies;Investigation;Language;lexical;literacy;Literacy Programs;Measures;Mediating;Mediation;Mental Health;method development;Methods;Modeling;motion sensitivity;Multimodal Imaging;multimodal neuroimaging;multimodality;Nerve Degeneration;neurodegenerative phenotype;neuromechanism;New York;Occupational;oculomotor;Onset of illness;Outcome;Outcome Study;Patient Recruitments;Patients;Pattern;Pharmaceutical Preparations;phonology;Population;Population Control;Prevalence;Process;programs;prospective;Quality of life;Reader;Reading;reading ability;reading difficulties;recruit;remediation;Role;Saccades;sample fixation;Schizophrenia;School-Age Population;Schools;screening program;Sensory;sensory integration;service utilization;Services;side effect;skills;social;social cognition;social determinants;Societies;Stimulus;success;Symptoms;Testing;Text;Training Programs;Visual;visual information;visual tracking;Work

PROJECT_TITLE: Neural Mechanisms of Reading Dysfunction in Schizophrenia


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The majority of individuals with opioid use disorder (OUD) smoke cigarettes, and they have less success quitting smoking and higher rates of tobacco-related mortality compared to the general smoking population. Novel cigarette reduction approaches, such as substitution of electronic cigarettes (e-cigarettes) for combusted cigarettes, are urgently needed in this population. This proposal will employ a randomized waitlist-controlled trial with a mixed-methods sequential explanatory design to investigate the feasibility, acceptability, and preliminary effects of substituting e-cigarettes for cigarettes on tobacco use and exposure (e.g., cigarettes smoked per day, biomarkers, cigarette dependence) in individuals who smoke (not ready to quit smoking) receiving OUD treatment, to help inform tobacco control policy and clinical practice.

PI_NAMEs: STRECK, JOANNA  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Acceleration;Address;Adult;Adverse effects;Aerosols;Anabasine;Applications Grants;Area;Behavior;behavior change;Biological Markers;Buprenorphine;buprenorphine treatment;Carbon Monoxide;career;Categories;Cigarette;cigarette smoke;cigarette smoking;clinical practice;Clinical Trials;combustible cigarette;comorbidity;Competence;Conduct Clinical Trials;Cotinine;Cross-Sectional Studies;Data;Data Analyses;Death Rate;Decision Making;Dependence;design;Development;Devices;e-cigarette cessation;Educational process of instructing;Electronic cigarette;electronic cigarette use;Enrollment;Environmental Risk Factor;Epidemic;Evaluation;experience;Exposure to;Faculty;FDA approved;Foundations;Future;General Hospitals;General Population;Goals;Harm Reduction;Health;High Prevalence;Individual;interest;International;Intervention;Interview;K-Series Research Career Programs;Knowledge;Marketing;Massachusetts;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;mortality;Motivation;National Institute of Drug Abuse;Nicotine;non-smoker;novel;novel strategies;opioid use disorder;Outcome;Outcome Measure;Participant;patient oriented;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;pod mods;Policy Making;polysubstance use;Population;Prevalence;preventable death;primary care practice;primary outcome;prospective;psychiatric symptom;public policy on tobacco;Randomized;Randomized, Controlled Trials;recruit;reduce tobacco use;reduced substance use;Reporting;Research;Research Design;Research Methodology;Research Personnel;Respiratory Signs and Symptoms;retention rate;skills;Smoke;Smoker;Smoking;smoking cessation;smoking intervention;social;Standardization;Stimulus;substance use;success;Testing;therapy development;Tobacco;tobacco exposure;Tobacco smoke;Tobacco smoking behavior;Tobacco use;tool;Toxin;Training;Vulnerable Populations;Waiting Lists;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE This is a request to support the inaugural Nerve SPACE (Setting Priorities to Advance Clinical and Research Efforts in Nerve Injury) Conference, which will bring together nerve surgeons, researchers, and stakeholders who are mutually dedicated to improving upper and lower extremity function and quality of life after nerve injury. The Nerve SPACE conference will allow both established experts and emerging researchers the opportunity to exchange ideas and foster collaboration in an intimate and collegial setting. The overarching goals of the Nerve SPACE conference will be to build consensus on knowledge gaps to and to identify areas for short-term and long-term focus for clinical and research efforts and resources.

PI_NAMEs: DY, CHRISTOPHER JOHN (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Academic Medical Centers;Achievement;Address;Advocate;Area;Atmosphere;Caring;Clinical;clinical care;Clinical Research;Collaborations;Communication;Consensus;Dedications;Development;Diagnosis;Discipline;Environment;Esthesia;Fostering;functional restoration;Future;Goals;Hand;Imaging technology;improved;Industry;innovation;insight;International;Investigation;Knowledge;Limb structure;Lower Extremity;meetings;Microsurgery;Musculoskeletal System;Nerve;nerve injury;nerve repair;Neurologist;Neurosurgeon;neurosurgery;Operative Surgical Procedures;Orthopedic Surgery;Orthopedics;Outcome;Pain;Participant;Patients;Peripheral nerve injury;Peripheral Nerves;Philosophy;Plastic Surgeon;Plastic Surgical Procedures;Positioning Attribute;Postoperative Pain;Productivity;Prognosis;programs;Quality of life;Reconstructive Surgical Procedures;Recording of previous events;Research;Research Personnel;Research Priority;Resources;Specialist;Surgeon;symposium;Techniques;Thinking;Translational Research;treatment strategy;Universities;Upper Extremity;Washington

PROJECT_TITLE: Setting Priorities to Advance Clinical and Research Efforts in Nerve Injury - Nerve SPACE

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Antimicrobial resistance (AMR) is a significant global health concern with implications for both human and animal health, with worldwide deaths due to AMR predicted to rise to 10 million people annually by 2050. The actions and policies taken to combat the emergence of AMR and prevent the inappropriate use of antimicrobial drugs are collectively known as antimicrobial stewardship (AMS); antifungal use and resistance likely play a role in veterinary AMS but there is a paucity of information despite the increase of resistant fungi as a public health threat. This proposed project will collect data regarding current antifungal use and resistance in companion animals as well as inform on clinical outcomes of companion animals prescribed antifungal drugs.

PI_NAMEs: COLE, STEPHEN DOUGLAS (contact);HSIEH, EMMELYN

PROGRAM_OFFICER_NAME: MILLER, MEGAN

PROJECT_TITLE: A Pilot Study of Veterinary Antifungal Use and Resistance in Support of Vet-LIRN's Antimicrobial Stewardship Efforts

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CVM-T (01)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative HIV co-infection accelerates liver cirrhosis and liver cancer in chronic hepatitis B virus (HBV) carriers. Our proposed work will establish robust and physiologically relevant primary cell culture systems to study HIV/HBV co-infections. These systems will provide a platform to develop novel antiviral strategies that may lead to a functional HBV cure.

PI_NAMEs: MICHAILIDIS, ELEFTHERIOS  (contact)

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Antigens;antiretroviral therapy;Area;biomarker identification;CD4 Positive T Lymphocytes;Cell Culture System;Cell Line;Cell Separation;Cells;Chronic;Chronic Hepatitis B;chronic infection;Circular DNA;co-infection;Coculture Techniques;curative treatments;Detection;drug development;drug resistance development;e Antigens;Exhibits;Genetic Transcription;Goals;Health;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Vaccines;Hepatitis B Virus;Hepatocyte;hepatoma cell;high risk;HIV;HIV Infections;Human;humanized mouse;Immune response;In Vitro;Individual;Infection;innovation;insight;Interferon alpha;Investigation;Knowledge;Life;Life Cycle Stages;Link;Liver;Liver Cirrhosis;Liver diseases;Maintenance;Malignant neoplasm of liver;Measurement;Messenger RNA;Modeling;Mus;Nature;novel;Nuclear;nucleoside analog;overexpression;Patients;Persons;Physiological;predictive marker;Primary carcinoma of the liver cells;Primary Cell Cultures;prophylactic;Research;response;Risk;RNA;RNA-Directed DNA Polymerase;spheroids;System;Time;transcriptome;transcriptome sequencing;transcriptomics;Viral;Viral Genome;viral rebound;Virus;virus core;Virus Diseases;Virus Receptors;Virus Replication;Withholding Treatment;Work

PROJECT_TITLE: Primary cell culture models of HIV/HBV co-infection

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE To understand the molecular and cellular mechanisms how protective immune responses are elicited by invading pathogens or vaccines would be useful for the design of vaccines. This project aims to study mechanisms of B cell responses to particulate antigens, or mock viral particles, at molecular and cellular level. The successful completion of this project will fill in a gap in our knowledge regarding how B cells may be activated by viral pathogens.

PI_NAMEs: CHENG, WEI  (contact);ZIKHERMAN, JULIE

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Address;Affinity;Animals;Antibodies;Antibody Response;Antibody titer measurement;Antigens;Autoantigens;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Biophysics;Cell Communication;Cells;Chemicals;Dedications;density;Dissection;DNA;Encapsulated;Ensure;Epitopes;Event;expectation;Exposure to;functional outcomes;Generations;Genetic;Genetic Materials;Germ Lines;Goals;Human;Immune response;Immunity;Immunoglobulin Class Switching;Immunoglobulin G;In Vitro;in vivo;Individual;Infection;innovation;Invaded;Investigation;Knowledge;Liposomes;live cell imaging;Mediating;Membrane Proteins;Memory B-Lymphocyte;MHC Class II Genes;Modeling;Molecular;Mus;novel;novel vaccines;Nucleic Acids;particle;Particle Size;Particulate;pathogen;pathogenic virus;Plasma Cells;programs;Proliferating;Proteins;rational design;Receptor Signaling;Recovery;Reporter;response;RNA;Shapes;Signal Pathway;Signal Transduction;single molecule;success;Surface;Surface Antigens;synergism;System;T-Lymphocyte;Techniques;Testing;Time;Titrations;Toll-like receptors;Transgenic Model;Vaccine Design;Vaccines;Viral;Viral Antigens;Viral Genome;viral pandemic;Viral Vaccines;Virion;Virus;Virus Diseases

PROJECT_TITLE: Mechanisms of B cell responses to particulate antigens

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Eczema / Atopic Dermatitis;Food Allergies;Microbiome;Nutrition;Pediatric;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative for the SEAL (Stopping Eczema and ALlergy) Study Food allergy (FA) is an epidemic among children in the U.S., U.K., and other countries. By reducing dry skin, the duration and severity of eczema and preventing eczema exacerbations with skin barrier protection and anti-inflammatory creams, we aim to significantly reduce the incidence of food allergy.

PI_NAMEs: LACK, GIDEON ;LEUNG, DONALD YM;NADEAU, KARI C. (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: 1 year old;3 year old;Allergens;Allergic inflammation;allergic response;Allergy to peanuts;Anti-Inflammatory Agents;arm;Atopic Dermatitis;atopy;B-Lymphocytes;Basophils;Biological Markers;Blood;Caring;CD8B1 gene;Cells;Child;Clinical;Clinical Research;cohort;commensal bacteria;comparison control;Complex;Country;Cream;Cytometry;Development;Disease;Dryness;dysbiosis;Eczema;Emollients;Epidemic;Epithelium;filaggrin;food allergen;food challenge;food consumption;Food Hypersensitivity;Functional disorder;Genes;genetic testing;high risk infant;Hypersensitivity;IgE;immune function;Immune response;Immunoglobulin Class Switching;improved;Incidence;infancy;Infant;Inflammation;Inhalant dose form;Interleukin-10;Interleukin-13;Intervention;Intervention Trial;Learning;Life;Lipids;Lymphoid Cell;mast cell;Mediating;Metagenomics;microbial;Monitor;monocyte;novel;Oatmeal Powder;Oral;oral tolerance;Participant;patient retention;Prevalence;prevent;Prevention;primary endpoint;prospective;Proteins;Proteomics;Randomized;Recommendation;recruit;Regulatory T-Lymphocyte;repaired;Research;respiratory;Risk;Role;secondary outcome;Secondary Prevention;Severities;Skin;skin barrier;Skin Care;skin microbiota;Somatic Mutation;standard of care;Staphylococcus aureus;Steroids;Stratum corneum;T cell receptor repertoire sequencing;Techniques;Testing;Th2 Cells;Time;Topical application;transcriptomics;treatment arm;treatment group;trial design;TSLP gene;Variant;γδ T cells

PROJECT_TITLE: SEAL (Stopping Atopic dermatitis and ALlergy) Study: Prevent allergy by enhancing the skin barrier


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Epidemiologic research into the exposome, or sum of human environmental exposures across the lifecourse, will benefit from coordinated efforts and resources that leverage disparate data sets to create a whole that is greater than its parts. The HHEAR Data Center will provide critical resources, expertise, and infrastructure enabling investigators to pool multiple datasets; access, analyze, and interpret these data; and to address hypotheses that go beyond their original funded aims. By achieving this mission, the HHEAR Data Center will accelerate the pace of environmental health research throughout the community to examine the environment on an exposome scale.

PI_NAMEs: TEITELBAUM, SUSAN L (contact)

PROGRAM_OFFICER_NAME: DUNCAN, CHRISTOPHER GENTRY

PROJECT_TERMS: Acceleration;Address;analytical method;Area;Big Data;Bioinformatics;Biological Markers;Biometry;Catalogs;Child;Child Health;Collaborations;Collection;Communities;computer science;Computing Methodologies;Consultations;cost;Data;Data Analyses;data centers;data integration;data management;Data Management Resources;data repository;data resource;data reuse;Data Science Core;data science resource;Data Scientist;Data Set;data sharing;data standards;design;Development;Dimensions;Disparate;Ensure;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Health;Environmental Impact;Epidemiology;epidemiology study;epigenomics;experience;Extramural Activities;Faculty;Foundations;Funding;Goals;Health;health data;health goals;Health Services;Human;Individual;Infrastructure;innovation;Institution;interoperability;Laboratories;Lead;Leadership;Life Cycle Stages;life span;Maintenance;Measurement;medical schools;metabolomics;metadata standards;Methodology;Mission;multidimensional data;multiple datasets;National Institute of Environmental Health Sciences;novel;Ontology;Outcome;Positioning Attribute;Process;repository;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Retrieval;Science;Scientific Advances and Accomplishments;Services;skills;Statistical Data Interpretation;Statistical Methods;statistical service;study population;Sum;support network;tool;usability;Vocabulary;Work

PROJECT_TITLE: Human Health Exposure Analysis Resource (HHEAR) Data Center


NIH_SPENDING_CATS: Data Science

PROJECT_TERMS: Adoption;Advisory Committees;Agreement;Benchmarking;Biological;Client;Collaborations;Communities;Consultations;Data;data access;Data Analyses;data centers;Data Coordinating Center;data management;data repository;data resource;data reuse;Data Science Core;data science resource;data sharing;data standards;Deposition;design;Development;Documentation;Effectiveness;Ensure;Environment;Environmental Exposure;Environmental Health;epidemiologic data;FAIR principles;flexibility;Goals;Health;Health Resources;Human;implementation process;Infrastructure;Institutional Review Boards;Laboratories;Leadership;Life Cycle Stages;Maintenance;Maps;meetings;member;Metadata;Methodology;Mission;National Institute of Environmental Health Sciences;new technology;Ontology;Production;Productivity;programs;Progress Reports;quality assurance;Recommendation;Research;Resource Informatics;Resources;Retrieval;Sampling;Services;Statistical Data Interpretation;Statistical Methods;statistical service;Structure;Testing;Training;Translations;United States National Institutes of Health;user-friendly;Visit;Vocabulary;web site

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: KOVATCH, PATRICIA  (contact)

PROJECT_TERMS: Acceleration;Address;analytical method;analytical tool;Big Data;Child Health;Collaborations;Collection;Communities;Computer software;Data;data access;Data Aggregation;Data Analyses;Data Analytics;data centers;data harmonization;data integrity;data management;data portal;data repository;data resource;data reuse;Data Science;Data Set;data sharing;data standards;data submission;data visualization;Deposition;Descriptor;design;Documentation;Economic Models;Eligibility Determination;Ensure;Environmental Exposure;Environmental Health;experience;FAIR principles;federated data;flexibility;Future;General Population;Generations;genome wide association study;Guidelines;Health;Health Insurance Portability and Accountability Act;health management;Human;implementation process;Individual;Infrastructure;Ingestion;interoperability;Intuition;Laboratories;large datasets;Life;Life Cycle Stages;Maps;metabolomics;Metadata;Modernization;multimodal data;Policies;Procedures;Process;Productivity;programs;quality assurance;query tools;Reporting;Reproducibility;Research;Research Personnel;Resources;Retrieval;Role;Sample Size;Scientific Advances and Accomplishments;Secure;Security;Self Direction;Semantics;Services;social media;study population;tool;Training;United States National Institutes of Health;usability;user-friendly;Visualization software;Vocabulary;webinar;Work

PROJECT_TITLE: Data Repository and Management Core


NIH_SPENDING_CATS: Clinical Research;Data Science;Pediatric;Prevention;Social Determinants of Health

PI_NAMEs: GENNINGS, CHRIS  (contact)

PROJECT_TERMS: Achievement;Adolescence;Affect;Air Pollution;Area;Bioinformatics;Biological Markers;Biometry;Body System;Categories;Chemicals;Child;Childhood;Collaborations;Communities;Complex;Computer software;Conceptions;Consultations;consumer product;critical period;Data;data centers;data resource;Data Set;Development;Dimensions;Disease;early life exposure;Environment;Environmental Exposure;Environmental Health;Environmental Impact;Environmental Pollutants;Environmental Risk Factor;Epidemiology;experience;exposed human population;Exposure to;Faculty;falls;Functional disorder;Health;health data;health goals;Human;innovation;Knowledge;Laboratories;Learning;Life;Life course epidemiology;Life Cycle Stages;life span;lifestyle factors;Measures;Mediating;Mediation;Meta-Analysis;method development;Methodology;Methods;Mission;multidimensional data;multidisciplinary;National Institute of Environmental Health Sciences;novel;nutrition;Outcome;Oxidative Stress;Pathway Analysis;Pattern;Physiology;programs;protocol development;Quality Control;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Resources;response;Risk;Risk Factors;Sample Size;simulation;spatiotemporal;Statistical Data Interpretation;Statistical Methods;statistical service;Statistical Study;statistics;Stress;Techniques;Training;webinar;Writing

PROJECT_TITLE: Statistical Services and Analysis Resource


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Neuromonitoring tools capable of reporting detailed brain signaling information stand to deepen our understanding of neural phenomena, informing improved diagnoses and treatments for neurological disorders and diseases. Although deep brain circuits are known to critically regulate key behaviors, including stress response, motivation, and social interaction, access to these regions by tools capable of large and specific cell population interrogation, such as optical imaging probes, is limited without incurring inflammatory disruption to the tissue environment and restricting animal behavior. This F32 proposal will develop thin, flexible imaging probes augmented by electrical stimulation and recording capabilities, as well as wireless back-end electronics, and deploy these tools to study circuit-level underpinnings of social behaviors in rodents, demonstrating their value to the neuroscience community as powerful and minimally perturbative recording platforms.

PI_NAMEs: CANNON, TAYLOR MARIE (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: 3-Dimensional;Acute;Animal Behavior;Animals;Behavior;Behavioral Assay;biological adaptation to stress;Biological Assay;Brain;Brain region;brain tissue;Calcium;career development;Cells;Chemical Stimulation;Chemicals;Chronic;Clinical;Cognitive Science;Color;Communication;Communities;Complex;Coupling;Custom;Data;data streams;design;Devices;Diagnosis;Diameter;Dopamine;Electric Stimulation;Electrical Engineering;Electronics;Electrophysiology (science);Elements;Environment;Exhibits;experimental study;fabrication;Fiber;flexibility;Foreign Bodies;Foundations;Functional Imaging;Future;Head;head mounted display;Image;imaging capabilities;Imaging Device;imaging probe;Imaging Techniques;Immune response;Implant;implantable device;improved;in vivo;in vivo imaging;Individual;Inflammatory;Inflammatory Response;insight;interest;Investigation;lens;Light;light weight;Longevity;Massachusetts;materials science;Mediating;Mentors;Methods;Microelectrodes;Microfluidics;Microscope;millisecond;Monitor;Motivation;multidisciplinary;multimodality;Nature;Nervous System Disorder;neural;Neurons;Neurosciences;neurotransmission;neurotransmitter release;Neurotransmitters;Nucleus Accumbens;optical imaging;Optics;Pathway interactions;Performance;Physiology;Polymers;Population;Preparation;preservation;reconstruction;Refractive Indices;Reporting;Resolution;Resource Development;Resources;response;Rewards;Rodent;sensor;Signal Pathway;signal processing;Signal Transduction;Site;Social Behavior;social deficits;Social Interaction;Social isolation;spatiotemporal;Stimulus;Stress;Technology;Thinness;Three-Dimensional Imaging;Time;Tissues;tool;Training;Training Programs;transmission process;Visualization;waveguide;wearable device;wireless;wireless data transmission;wireless electronic;wireless sensor;Work

PROJECT_TITLE: A multifunctional fiber platform for wireless, volumetric imaging and modulation of neural activity in vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (06)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Genetics;Human Genome;Lung;Microbiome;Nutrition;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Thirty-three percent of children admitted to the intensive care unit with pediatric acute respiratory distress syndrome (PARDS) die prior to hospital discharge. Emerging data suggests that gut microbes living within us may influence PARDS progression or severity, and other organ dysfunction. Our research program will study how feeding strategies during PARDS, may improve the type of microbes in our gut, and may be a new approach to improve lung inflammation and injury, organ dysfunction, and survival in these children.

PI_NAMEs: TYPPO, KATRI VANAMO (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acetates;Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Admission activity;Ancillary Study;Animal Model;Anti-Inflammatory Agents;Antiinflammatory Effect;Architecture;aspirate;Bacteria;beta diversity;biobank;Biological Markers;Butyrates;Cell Nucleus;Cells;Child;Childhood;Clinical;Clinical Trials;commensal bacteria;Communities;Critical Illness;cytokine;Data;Diagnostic;Diet;Disease;Dryness;endotracheal;Enteral Nutrition;feeding;Functional disorder;Funding;Gene Expression Profile;gut bacteria;gut dysbiosis;gut microbes;gut microbiome;gut microbiota;Hospitals;Immune;improved;improved outcome;Infrastructure;innovation;Intensive Care Units;Knowledge;Life;Lower Respiratory Tract Inflammation;Lung;lung injury;lung microbiome;Measures;Mechanical ventilation;Mediator;metagenomic sequencing;Metalloproteases;Microbe;microbial;microbial based therapy;microbiome;microbiome signature;mortality;mortality risk;novel;novel strategies;novel therapeutics;nutrition;Nutrition Therapy;Oral;Organ;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Pediatric Acute Respiratory Distress Syndrome;Population;Positioning Attribute;prebiotics;preservation;Process;Production;programs;Pulmonary Inflammation;Pulmonary Surfactant-Associated Protein A;Randomized;Randomized, Controlled Trials;receptor for advanced glycation endproducts;Research;Retrospective Studies;Risk Assessment;Secretory Cell;secretory protein;Severities;Shotguns;Signal Transduction;single nucleus RNA-sequencing;Specimen;stool sample;Structure;targeted treatment;Testing;Trachea;transcriptome sequencing;treatment as usual;United States National Institutes of Health;ventilation;Volatile Fatty Acids;whole genome

PROJECT_TITLE: Microbiome and Nutrition in Severe PARDS

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Lung;Patient Safety;Precision Medicine;Sarcoidosis

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Pulmonary sarcoidosis is a condition that ranges in severity from mild and self-limiting--meaning it goes away without chronic therapy--to life-threatening with end-stage irreversible organ damage. There are no reliable “tools” available to the clinician that provide useful information about a patient’s future risk of having progressive lung disease and without these tools, clinicians cannot make the best care decisions for their patients. This study was designed to address these unmet clinical needs by creating and testing these “tools” using blood test results and clinical information from several groups of people across the United State who have sarcoidosis.

PI_NAMEs: KOTH, LAURA L (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;African American;Age;Area Under Curve;Blood;Blood Proteins;Blood Tests;blood-based biomarker;Caring;chemokine;Chronic;Chronic Disease;Clinic;Clinical;Clinical Data;clinical development;Clinical Management;clinical practice;Clinical Practice Guideline;clinical predictive model;clinical predictors;Clinical Research;clinically relevant;cohort;Collaborations;Collection;Conceptions;Costs and Benefits;Cox Proportional Hazards Models;current pandemic;CXCL10 gene;CXCL11 gene;CXCL9 gene;Data;Data Analyses;Data Set;design;disease natural history;Disease Progression;Drops;Drug toxicity;Enrollment;Evaluation;Event;follow-up;Frequencies;Future;Goals;hazard;high risk;Immunosuppression;improved;Individual;Inflammation;Interferons;Intervention;Investigation;Laboratories;Life;longitudinal care;Longitudinal cohort;Lung;Lung Diseases;Measures;Medical;Messenger RNA;Modeling;Monitor;Motivation;novel;novel marker;Organ;Outcome;patient stratification;Patients;Performance;Persons;Physicians;Policies;predictive tools;Probability;prognostic;prognostic indicator;prognostic model;prognostic tool;prognostic value;prognostication;Provider;Publishing;pulmonary function;pulmonary function decline;Pulmonary Sarcoidosis;Qualifying;Race;Research;Research Design;Research Personnel;Resources;Risk;risk stratification;RNA;Sample Size;Sarcoidosis;Schedule;Serum;Serum Proteins;Severities;sex;success;systematic review;Test Result;Testing;Thoracic Radiography;Time;Tobacco;tool;Toxic effect;Training;training data;Transcript;Translating;Translations;United States;United States National Institutes of Health;Validation;Visit;Whole Blood;Work

PROJECT_TITLE: Development of Clinical Prediction Models for Pulmonary Outcomes in Sarcoidosis

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cancer;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Aging is a complex process that drives increased cancer risk in tissues throughout the body, including the blood system. To understand why aged individuals have higher risk of developing blood cancers, there is a vital need to understand the mechanisms by which aging contributes to clonal expansion and transformation. This research is relevant to public health because it will provide mechanistic insights into effective therapeutic strategies to target clonal evolution, attenuate pathophysiology promoted by clonal expansion, and intercept malignant transformation.

PI_NAMEs: LEVINE, ROSS L;TROWBRIDGE, JENNIFER JEAN (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Age;age related;aged;Aging;aging population;aging related;Attenuated;biobank;Bioinformatics;Blood;Bone Marrow;cancer risk;Clonal Evolution;Clonal Expansion;cohort;Collaborations;Complex;DNMT3a;DNMT3a mutation;Epigenetic Process;fitness;Functional disorder;Genetic;Goals;Health;healthy aging;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;Hematopoietic Neoplasms;hematopoietic stem cell expansion;Hematopoietic Stem Cell heterogeneity;Hematopoietic Stem Cell subsets;Hematopoietic stem cells;Heterogeneity;high risk;Human;human data;improved;Inflammation;Inflammatory;innovation;insight;Intercept;interdisciplinary approach;interest;Intervention;Link;Malignant - descriptor;middle age;Molecular;Molecular Biology;Mus;Mutate;new therapeutic target;novel;Outcome;pressure;Process;Property;Public Health;Quality of life;Research;response;Risk;risk mitigation;Role;Sampling;Signal Transduction;single cell technology;Somatic Mutation;stem cell biology;stem cell population;stem cells;System;Testing;therapeutically effective;Tissues;Work

PROJECT_TITLE: Inflammatory Signaling in DNMT3A-Mutated Human Hematopoietic Stem Cells


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: TUCSON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative: Various physiological and psychological variables influence our decision making, but little is known about how the brain represents factors like heart rate or emotional state, or the neural mechanisms by which these factors bias the decision-making process. Here I propose to evaluate these mechanisms by recording from the non- human primate prefrontal cortex while they perform social and non-social decision-making tasks and either visceral or brain physiology is manipulated. The research described herein will provide a strong backbone upon which I will receive training in experimental and computational neurophysiology, as well as in the use of causal genetic manipulations in non-human primates.

PI_NAMEs: CARDENAS, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Affect;Animals;Anterior;anti social;approach/avoidance behavior;Area;Arousal;Automobile Driving;avoidance behavior;Behavior;Behavioral;Brain;Callithrix;career;cingulate cortex;Cognitive;Communication;Complex;Data;Data Analyses;Decision Making;Emotional;Equilibrium;experimental study;Forearm;genetic manipulation;Glycopyrrolate;Goals;Heart Rate;Human;indexing;Infusion procedures;insight;interest;Interoception;Juice;Learning;Life;Macaca mulatta;Modeling;Modernization;Monkeys;Motivation;Muscarinic Acetylcholine Receptor;neural;neural circuit;neural correlate;neurogenetics;neuromechanism;Neurons;neurophysiology;nonhuman primate;Nutrient;optogenetics;Peripheral;Pharmaceutical Preparations;pharmacologic;Phase;Physiological;Physiology;post-doctoral training;Postdoctoral Fellow;Prefrontal Cortex;Primates;Process;psychologic;Psychological Factors;Research;Research Personnel;response;Rewards;Role;Shapes;Signal Transduction;skills;social;social structure;Spinal Cord;Stimulus;Tachycardia;Techniques;Training;Trust;Universities;Vagus nerve structure;Value Orientations;Vertebral column;Viscera;Visceral

PROJECT_TITLE: Effects of Internal State on Social and Non-Social Decision Making in the Non-Human Primate Prefrontal Cortex

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_DEPT: BIOCHEMISTRY

PHR: NARRATIVE  Cancer immunotherapies have achieved impressive clinical outcomes in a small subset of cancer patients. We will develop a novel therapeutic agent that can boost cancer immunotherapies. We expect that successful completion of this project will make a significant impact on cancer treatments.

PI_NAMEs: WANG, JIN  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Accounting;Advanced Malignant Neoplasm;anti-PD-1;Antigens;Biological Assay;Biology;biomarker identification;cancer cell;Cancer cell line;cancer immunotherapy;Cancer Patient;cancer therapy;Canis familiaris;Cell Survival;Cells;Chemicals;Clinical;clinical translation;Complex;congenital immunodeficiency;Development;Dose;Drug Exposure;efficacy evaluation;Future;Genetic study;gut inflammation;Half-Life;Human;humanized mouse;Immune;immune checkpoint blockade;Immune system;Immunocompetent;Immunophenotyping;Immunotherapy;improved;in vivo;Individual;Induction of Apoptosis;Inflammatory;inhibitor;innate immune pathways;innovation;Interferons;Intervention;Investigation;Knock-out;Ligands;loss of function;Melanoma;meter;Modeling;Monkeys;Monoclonal Antibodies;mouse model;multiple omics;Mus;Mutation;novel therapeutics;Oral;Outcome;Pathway interactions;patient response;patient stratification;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology and Toxicology;Phenocopy;Phenotype;Phosphotransferases;Plasma;potential biomarker;Pre-Clinical Model;Property;Protac;Protein Kinase Interaction;Proteins;Proteome;Proteomics;Rattus;Receptor-Interacting Protein;recruit;Research;response;Scaffolding Protein;Signal Transduction;species difference;Specificity;success;Symptoms;synergism;T-Cell Activation;Technology;Testing;Therapeutic;Therapeutic Agents;TNF gene;Toll-like receptors;transcriptome;Transgenic Mice;Transgenic Organisms;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Immunity;tumor initiation;tumor microenvironment;Variant;Work

PROJECT_TITLE: Development of First-in-Class RIPK1 Degraders to Improve Cancer Immunotherapies

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: Project Narrative Acute myeloid leukemia (AML) is the most lethal hematological malignancy, and alternatives to chemotherapy such as differentiation therapy are greatly needed. We recently found that the H3K9 histone acetyltransferase KAT6A cooperates with the H3K9ac reader protein ENL to promote stemness and proliferation in AML. Here, we aim to determine the molecular mechanisms by which KAT6A and ENL cooperate to drive leukemogenic gene expression programs, and to identify the genetic subtypes of AML that are most sensitive to KAT6A inhibition.

PI_NAMEs: BLANCO, MARIO ANDRES (contact)

PROGRAM_OFFICER_NAME: SAYYED, ZULEKHA I

PROJECT_TERMS: Ablation;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Binding;Biochemical;Biological Assay;burden of illness;Cell Cycle;Cell Differentiation process;Cell Proliferation;Cell Survival;Cells;chemotherapy;Chimeric Proteins;ChIP-seq;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complex;CRISPR screen;Data;design;Differentiation Therapy;Disease;Disease Progression;Disease remission;DNMT3a;ENL Protein;Epigenetic Process;epigenome;epigenomics;FLT3 gene;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Hematologic Neoplasms;Hematopoiesis;histone acetyltransferase;histone-binding proteins;Human;Impairment;In Vitro;in vivo;Individual;inhibitor;KDM1A gene;Knock-out;Mass Spectrum Analysis;Methodology;Methods;Methylcellulose;MLL-AF9;MLL-rearranged leukemia;Modeling;Molecular;mouse model;Mus;mutant;Myelogenous;novel;Oncogenes;Patients;Pharmaceutical Preparations;Play;programs;Progranulocytes;Proliferating;promoter;protein complex;Reader;recruit;response;Role;Sampling;Scheme;self-renewal;small molecule;stemness;success;synergism;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Toxic effect;transcription factor;transcriptome;transcriptome sequencing;transplant model;treatment effect;Work;Xenograft Model

PROJECT_TITLE: Investigating the role of KAT6A in MLL-rearranged acute myeloid leukemia

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The goal of this proposal is to improve the guideline-concordant breast cancer (BC) screening among Latinas living in Chicago, by testing a new empowerment (empower) approach - wherein non-adherent Latinas are empowered to become informal breast health leaders in their community and are navigated to affordable, accessible care. We will examine if, relative to traditional approaches, the empower approach leads to greater BC screening among non-adherent Latinas and women in their social networks. We will also explore and identify the “active ingredients” that lead to greater BC screening in the empower approach - including greater knowledge, motivation to be a healthy role model, volunteerism in community BC initiatives, potential to “bridge” network members with formal change agents (e.g., community health workers, navigators), acceptability to promote BC, feasibility to promote BC, and BC promotion to network members.

PI_NAMEs: MOLINA, YAMILE  (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: acceptability and feasibility;Address;arm;Breast;Breast Cancer Detection;breast cancer diagnosis;cancer care;Caring;Chicago;Clinical;Collaborations;Communication;Communities;community engagement;Community Health Aides;Community Health Education;community intervention;community organizations;community research;comparison intervention;cost;Data;design;diagnosis quality;Education;Educational process of instructing;empowerment;Enrollment;Equation;experience;Family;Federally Qualified Health Center;Friends;Fright;Future;Goals;Guidelines;Health;Healthcare;implementation science;improved;Individual;innovation;Intervention;intervention effect;intervention participants;Knowledge;Latina;Latina Population;Latino;leadership development;Learning;Long-Term Effects;Malignant Breast Neoplasm;Mammography;Measures;Mediating;Mediation;member;Modeling;models and simulation;Motivation;novel;Pathway Analysis;peer;Pilot Projects;Population;Process;prospective;psychosocial;Quality of life;randomized, clinical trials;Randomized, Controlled Trials;recruit;Reporting;Role;role model;screening;screening guidelines;Services;skills;skills training;Social Network;social observations;Solid;Testing;Translations;United States Preventative Services Task Force;volunteer;Woman

PROJECT_TITLE: Empowering Latinas to Obtain Guideline-Concordant Breast Cancer Screenings

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE, Overall The ultimate goal of the Colorado (CO) Head and Neck Cancer (HNC) SPORE is to advance translational research to improve survival and quality of life for HNC patients. The strategies to accomplish this goal will take advantage of our expertise in basic and clinical sciences and unique model systems to identify novel molecular and cellular mechanisms of HNC pathogenesis that may be targeted for therapeutic interventions.

PI_NAMEs: JIMENO, ANTONIO  (contact);WANG, XIAO-JING

PROGRAM_OFFICER_NAME: HUBBARD, LEAH

PROJECT_TERMS: Address;Anatomy;anti-cancer research;base;Basic Science;Biological Models;Biopsy;Breathing;cancer cell;Cancer Model;cancer survival;cancer therapy;cancer type;career;Caring;Cell Physiology;Cell Survival;Cells;chemoradiation;Clinic;clinical application;Clinical Sciences;Clinical Trials;Colorado;Combination immunotherapy;Communication;Cyclin D1;Data;Data Science;Dedications;design;Development;Disabled Persons;Discipline;Endothelium;Epithelial-Stromal Communication;Eragrostis;Faculty;Fostering;Genetically Engineered Mouse;Goals;Grant;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Human;Human Papillomavirus;humanized mouse;Immune;Immune Evasion;Immunocompetent;Immunosuppression;Immunotherapy;improved;improved outcome;in situ vaccination;in vitro Model;in vivo;Infiltration;inhibitor;innovation;Investigational Therapies;Lead;Malignant neoplasm of salivary gland;Malignant neoplasm of thyroid;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;Mus;novel;novel therapeutic intervention;Oncogenic;optimal treatments;Organ;palliation;participant enrollment;Pathogenesis;Pathology;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Phase;phase I trial;Postdoctoral Fellow;pre-clinical;predictive marker;prognostic;Prognostic Marker;prognostic significance;programmed cell death ligand 1;programs;Proteins;Quality of life;Radiation therapy;recruit;Recurrence;Regimen;Regulatory T-Lymphocyte;Reproduction spores;Research;research and development;research clinical testing;Research Personnel;Research Project Grants;Resistance;Sampling;Signal Transduction;synergism;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Therapeutically Targetable;therapy development;Tissues;Tobacco;Transforming Growth Factor beta;Translating;translational cancer research;Translational Research;Translations;Treatment Efficacy;tumor;tumor microenvironment;Tumor-associated macrophages;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Vascular Endothelial Cell

PROJECT_TITLE: Colorado Head and Neck Cancer SPORE


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Infectious Diseases;Orphan Drug;Radiation Oncology;Rare Diseases

PHR: NARRATIVE, Project 2 This project aims to bring therapeutic intervention to patients with locally recurrent head and neck cancer. We will employ locally advanced mouse models and patient-derived xenografts for experimental therapeutics in immune competent and compromised conditions, perform mechanistic analyses, and initiate a Phase Ib clinical trial. We aim to bring a therapeutic intervention to simultaneously enhance immunotherapy and reduce RT resistance in head and neck cancer patients.

PI_NAMEs: WANG, XIAO-JING  (contact)

PROJECT_TERMS: Affect;Aftercare;Antibodies;antitumor effect;Attenuated;biomarker driven;Biopsy;Blood Cells;Cancer Biology;candidate validation;Catchment Area;CD8B1 gene;Cell Death;Cell Death Induction;cell killing;Cells;Cessation of life;Clinical;Colorado;DNA;DNA Damage;DNA Repair;Epithelial Cells;Epithelium;FDA approved;Fibrosis;Future;Genes;Growth;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;HPV positive;Human;Human Papillomavirus;Immune;immune activation;immune cell infiltrate;Immunocompetent;Immunosuppression;Immunosuppressive Agents;Immunotherapy;in situ cancer vaccine;in situ vaccination;Individual;Infiltration;inhibitor;Interferons;Investigational Therapies;ITGAM gene;Mediating;Medical Oncology;Metastatic Neoplasm to the Lung;Modeling;Molecular;molecular marker;mouse model;Mus;Mutant Strains Mice;Myeloid Cells;neoantigens;Neoplasm Metastasis;neoplastic cell;Nitroquinolines;novel;Nude Mice;Oral;oral HPV-positive head and neck cancers;oral mucositis;Oral mucous membrane structure;Outcome;Oxides;Pathway interactions;patient derived xenograft model;Patient Selection;Patients;Phase Ib Clinical Trial;Phase Ib Trial;phase II trial;Prediction of Response to Therapy;predictive marker;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;Radiation;radiation effect;Radiation Oncology;radiation response;Radiation therapy;recruit;Recurrence;Regimen;Relapse;Reporting;Resistance;response;Safety;Sampling;Science;Serum;Signal Transduction;small molecule;Specimen;Systemic Therapy;T cell receptor repertoire sequencing;T-Cell Receptor;T-Lymphocyte;targeted agent;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy outcome;Time;Tobacco;Toxic effect;Transforming Growth Factor beta;Transforming Growth Factors;Transplantation;treatment response;tumor;Tumor Antigens;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor Promotion;Tumor-Infiltrating Lymphocytes;vaccine response

PROJECT_TITLE: Treating recurrent HNSCC with radiation and dual TGF-Beta/PD-L1.


NIH_SPENDING_CATS: Prevention

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

ORG_STATE: MD

PHR: PROJECT NARRATIVE This project will coordinate the activities of several institutions that will provide sophisticated laboratory and data analysis capabilities that will work together to advance our understanding of the effect of environmental exposures on health across the human life course.

PI_NAMEs: MERRILL, LORI  (contact)

PROGRAM_OFFICER_NAME: COLLINS, JENNIFER B

PROJECT_TERMS: Access to Information;Address;Adherence;Adult;Biological;Books;Chemicals;Child;Child Health;Collaborations;Communication;Communities;Complex;Data;Data Analyses;data repository;data resource;Development;Electronic Mail;Eligibility Determination;Ensure;Environmental Exposure;Epidemiologist;Evaluation;experience;Exposure to;Extramural Activities;Genetic Predisposition to Disease;Goals;Health;health administration;Health Planning;Health Promotion;Human;indexing;Infrastructure;insight;Institution;interest;Laboratories;Leadership;Life Cycle Stages;life span;Link;Literature;Measures;Medical Research;method development;Methodology;Methods;Monitor;National Institute of Environmental Health Sciences;operation;Outcome;Performance;Positioning Attribute;Predisposition;prevent;Procedures;Process;programs;psychologic;quality assurance;Quality Control;Reporting;Research;Research Personnel;Research Priority;Resources;Risk Assessment;Sampling;Science;Services;social;social media;Specimen;Standardization;Statistical Data Interpretation;Statistical Methods;System;Toxicology;Training Activity;Update;web portal;web site;Work;working group

PROJECT_TITLE: Human Health Exposure Analysis Resource (HHEAR): Coordinating Center


ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Developmental critical periods are brief windows in development when animal experience drives activity- dependent remodeling, or plasticity, within brain circuits. Critical period plasticity is terminated by the association of neurons and a specialized glial population called astrocytes, and changes in astrocyte-neuron signaling can extend or contract neural plasticity. However, the consequences of altered critical period timing are still poorly defined. The proposed project will identify the long-term consequences of extending or precociously closing a critical period of motor circuit plasticity, which will provide valuable insight into how circuit structure and dynamics are linked to motor behavior.

PI_NAMEs: POSTOLACHE, MAGGIE  (contact)

PROJECT_TERMS: Ablation;Affect;Animal Behavior;Animal Model;Animals;Area;Astrocytes;autism onset;autism spectrum disorder;Axon;Behavior;Behavior assessment;Behavioral;Biological Assay;Biological Models;Brain;BRAIN initiative;Cell surface;Cell Surface Proteins;cell type;Cells;Chemicals;Communication;Contracts;critical developmental period;critical period;Data;Dendrites;Development;developmental plasticity;Disease;Drosophila genus;Embryo;Ensure;Equilibrium;Etiology;Excision;Excitatory Postsynaptic Potentials;Exhibits;experience;experimental study;fly;Frequencies;Genes;genetic manipulation;Genetic Models;Genetic Screening;Goals;hatching;Hour;Human;Impairment;in vivo;Individual;innovation;insight;Intervention;knock-down;Link;Locomotion;Long-Term Effects;Maintenance;model organism;Modeling;Motion;Motor;motor behavior;motor impairment;Motor Neurons;Motor output;Mus;Muscle;Muscle Cells;neural;neural circuit;neurodevelopment;Neuroglia;neuroligin 2;Neurologic Dysfunctions;Neuronal Plasticity;Neurons;neurotransmission;novel;optogenetics;Output;overexpression;Phenotype;Physiological;Physiology;Population;Publishing;RNA Interference;Role;Schizophrenia;Signal Transduction;Signaling Molecule;Speed;Structure;Synapses;synaptic function;System;Temperature;Testing;Time;tool;Work

PROJECT_TITLE: Long-term neural consequences of altered critical period timing.


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PI_NAMEs: BERTRAM, MICHAEL JAMES (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Abbreviations;Academic Medical Centers;Administrative Supplement;Alabama;anti-cancer research;Area;Automobile Driving;Back;Cancer Center;Cancer Center Support Grant;cancer prevention;Cancer Survivorship;Catchment Area;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Consultations;Data;Decision Making;Dedications;Development;Direct Costs;Education and Outreach;Ensure;Environment;Evaluation;evidence base;experience;Family;federal policy;functional group;Fund Raising;Funding;Gifts;Goals;Guideline Adherence;Guidelines;Industry;infrastructure development;Institution;Interdisciplinary Study;Intervention;Investments;Knowledge;Leadership;Life;Malignant Neoplasms;medical schools;member;Mission;Modeling;Monitor;Names;NCI-Designated Cancer Center;next generation;novel;operation;Operations Research;Patients;Philanthropic Fund;Policies;Process;programs;Protocols documentation;Qualifying;Recording of previous events;recruit;Reporting;Research;Research Support;Resource Allocation;Resource Sharing;Resources;Review Committee;Role;Services;software systems;Specialist;Strategic Planning;success;System;Training;Training and Education;tumor;Universities;Vision

PROJECT_TITLE: Cancer Center Administration

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Opioids;Pain Research;Patient Safety;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative One of the most challenging sequelae for patients undergoing spine surgery is chronic post-surgical pain (CPSP) which is associated with poor physical function and long-term opioid use. There is a significant need for effective nonpharmacologic interventions, such as Acceptance and Commitment Therapy, to prevent CPSP and long-term opioid use. Moreover, identifying psychosocial and psychophysical phenotypes associated with treatment efficacy will allow for a cost-effective, precision medicine approach.

PI_NAMEs: MEINTS, SAMANTHA M (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: acceptability and feasibility;Acute;Adherence;care seeking;Cessation of life;Chronic;chronic pain management;chronic pain patient;Clinical Trials;cost;cost effective;Development;Goals;improved;Intervention;Nonpharmacologic Therapy;Operative Surgical Procedures;opioid use;opioid use disorder;overdose risk;Patients;Phenotype;Physical Function;Population;Postoperative Pain;precision medicine;prescription opioid;prevent;Prevention;Prevention therapy;Psychophysics;psychosocial;Quality of life;response;Risk Reduction;Spine pain;Spine surgery;Therapeutic Intervention;therapy development;tool;Training;Treatment Efficacy

PROJECT_TITLE: PREventing Pain after Surgery: A feasibility and acceptability study of Acceptance and Commitment Therapy for the prevention of chronic post surgical pain (PREPS)


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: NEUROLOGY

PHR: Training Program in Neuroengineering and Medicine Disorders of the nervous system represent one of the largest, fastest growing areas of medical need in the United States and the most promising therapies for these disorders are new technologies to image, analyze, and modulate activity in neural circuits. There is a great need for engineers educated in clinical neuroscience and physicians with technical backgrounds to train and work together, to effectively bring these critical technologies to patient care. The goal of this multidisciplinary program is to train pre-doctoral engineering students, and post-doctoral MD and MD-PhD fellows together in Neuroengineering research, to translate their work to clinical care, and ultimately improve the lives of individuals with brain and nervous system disorders.

PI_NAMEs: LITT, BRIAN  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Medicine;Training Programs


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Diabetes;Emerging Infectious Diseases;Health Services;Infectious Diseases;Nutrition;Patient Safety;Pediatric;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Recent studies have found that infection with SARS-CoV-2 and COVID-19 diagnosis are associated with the development and progression of both Type 1 (T1D) and Type 2 Diabetes (T2D). The proposed study will engage 15 sites from the National Patient-Centered Clinical Research Network (PCORnet) and the T1D Exchange to recruit 1600 English- and Spanish-speaking pediatric and adult patients with recently diagnosed T1D or T2D who have had a known COVID-19 infection in the past 90 days or no recent diagnosis of COVID- 19 infection in the past year. The study will follow this population for 2 years and will utilize linked electronic health data from PCORnet sites to understand the impact of COVID-19 on diabetes.

PI_NAMEs: BLOCK, JASON PERRY;POWERS, ALVIN C;ROTHMAN, RUSSELL L. (contact);SCHILDCROUT, JONATHAN SCOTT

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: 2019-nCoV;Adult;American;Antibodies;Area;Beta Cell;Biological Markers;Biological Process;Blood Vessels;CDC42 gene;Cell Physiology;Cessation of life;Child;Childhood;Childhood diabetes;Clinical;Clinical Research;cohort;community engagement;Consent;COVID-19;COVID-19 diagnosis;COVID-19 impact;COVID-19 pandemic;COVID-19 patient;COVID-19 sequelae;COVID-19 surveillance;COVID-19 test;COVID-19 treatment;Data;data hub;Deterioration;Development;Diabetes Mellitus;Diagnosis;drug repurposing;electronic health data;Electronic Health Record;Environmental Risk Factor;Epidemiology;epidemiology study;experience;Family;Fibrosis;Funding;Future;Genomics;Glucose tolerance test;glycemic control;Health;Health Services Research;Health system;improved;Individual;Infection;Inflammation;Informatics;Infrastructure;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;Internet;Intervention;Intervention Studies;Link;Long COVID;member;Metabolic;metabolomics;Multicenter Trials;Non-Insulin-Dependent Diabetes Mellitus;Nucleocapsid;Obesity;Observational Study;Outcome;Outpatients;pandemic disease;Participant;patient oriented;patient portal;patient registry;patient subsets;Patients;Physiological;Physiology;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;Process;Public Health;Records;recruit;Registries;Research;Resources;Risk;Role;SARS-CoV-2 exposure;SARS-CoV-2 infection;SARS-CoV-2 negative;Serology test;Site;social;Spanish/English;Standardization;Structure;Study Subject;Surveys;Telephone;Testing;Thrombophilia;Time;type 2 diabetes in children;type I and type II diabetes;United States National Institutes of Health;Work

PROJECT_TITLE: CODA: COvid and Diabetes Assessment


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Narrative  Neisseria gonorrhoeae is the primary causative agent of the sexually transmitted infection, gonorrhea. We have found that N. gonorrhoeae can produce bacterial viruses (bacteriophage) and are investigating the mechanisms that allow phage to produce and infect other bacterial cells.

PI_NAMEs: SEIFERT, HANK S. (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Area;Bacteriophages;Biochemical;Biological Assay;Cells;Conserved Sequence;CRISPR interference;DNA analysis;DNA Damage;DNA Polymerase III;Down-Regulation;Essential Genes;Family;fitness;Genes;genetic approach;Genome;Genomic Islands;Genomics;Gonorrhea;Human;Hydrogen Peroxide;Infection;Island;Isopropyl Thiogalactoside;knock-down;Literature;Manuscripts;Morphology;Mutagenesis;Mutate;Mutation;Neisseria;Neisseria gonorrhoeae;Open Reading Frames;Orthologous Gene;oxidation;oxidative damage;paralogous gene;particle;Pathogenicity;Phenotype;Pilum;Production;Proteins;Publishing;receptor;Reporting;Repression;Sexually Transmitted Agents;Sexually Transmitted Diseases;Siphoviridae;Structural Genes;System;Testing;Transmission Electron Microscopy

PROJECT_TITLE: Investigating Neisseria gonorrhoeae double-stranded bacteriophage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-V (02)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The affirmative action restrictions issued by the Supreme Court on June 29, 2023, pose an existential threat to the ethnoracial diversity of the healthcare workforce. This study aims to investigate the impact of this court ruling on the compositional diversity and climate of equity and inclusion within MD and MD-PhD programs. The findings will inform crucial medical education policy decisions.

PI_NAMEs: BOATRIGHT, DOWIN  (contact);CHAUDHRY, SARWAT I;FANCHER, TONYA L.

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Academy;Accreditation;Address;Admission activity;Adopted;adverse outcome;Advocacy;Alaska Native;American Indians;American Medical Association;Association of American Medical Colleges;Black race;Caring;Characteristics;Climate;Congresses;Conscious;court;Disadvantaged minority;Doctor of Philosophy;doctoral student;Education;Equity;ethnic diversity;ethnic minority;Ethnic Origin;ethnoracial;experience;Funding;health care availability;health care disparity;health care quality;Health Policy;Health Services Accessibility;Healthcare;higher education;Improve Access;improved;Individual;innovation;Intervention;Interview;Knowledge;Latinx;matriculation;Medical;Medical Education;medical schools;Medical Students;Medicine;Minority;minority student;Mission;National Institute on Minority Health and Health Disparities;Native Americans;Native Hawaiian or Other Pacific Islander;Patients;Peer Review;Physicians;Play;podcast;Policies;Program Description;programs;Publications;Quality of Care;Race;racial diversity;racial minority;Recommendation;recruit;Reporting;Research;Role;Sampling;Science;Scientist;Selection Criteria;student retention;Student Selections;Students;symposium;Treatment outcome;undergraduate education;Underrepresented Students;United States Dept. of Health and Human Services;United States National Institutes of Health;United States Supreme Court;Variant;Vision Disparity

PROJECT_TITLE: Assessing Medical Student Applicants and Matriculants and Medical School Selection Criteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-C (02)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Substance Misuse

ORG_CITY: San Diego

ORG_NAME: VIVREON BIOSCIENCES, LLC

PHR: Vivreon Biosciences, LLC 4940 Carroll Canyon Rd., Ste. 110  San Diego, CA 92121 milton@vivreonbiosciences.com NIDA RFA-DA-23-021 Project Narrative Opioid use disorder (OUD) is the chronic use of opioid medications that causes clinically significant distress or impairment. Opioid dependence and OUD can develop upon accepted opioid therapy administered while in the ICU and other hospital care settings where pain treatment and sedation are needed. No pharmaceutical exists to prevent development of opioid dependence. With support from this grant project, Vivreon Biosciences seeks to further validate and advance a promising small molecule drug candidate to bring the first drug to market that can prevent development of opioid dependence.

PI_NAMEs: GREENBERG, MILTON L (contact)

PROGRAM_OFFICER_NAME: SABIRZHANOV, BORIS YEVGENYEVICH

PROJECT_TERMS: Absence of pain sensation;Address;Affect;Affective;Attenuated;Behavior;Behavioral;behavioral sensitization;Biological Availability;Biological Sciences;Brain;Calcium Channel;care costs;Cell membrane;Central Nervous System;Chronic;Clinical;clinically significant;combat;commercialization;cytokine;Data;Development;Diagnostic;Dimensions;Disease;disease model;Distress;dosage;Dose;drug candidate;drug craving;Financial Support;Funding;Gliosis;good laboratory practice;Grant;hospital care;Hospitalization;Hyperalgesia;Immunomodulators;Impairment;improved;indexing;Inflammatory;innovation;Inpatients;Intensive Care Units;Investigational Drugs;Lead;Length of Stay;manufacture;Marketing;Medical;Microglia;Mission;Modeling;Molecular;Morphine;mouse model;Mus;National Institute of Drug Abuse;neuroinflammation;Neurons;neuroprotection;neurotoxic;new chemical entity;new therapeutic target;non-opioid analgesic;novel;Opiate Addiction;Opioid;opioid exposure;Opioid Receptor;opioid tapering;opioid therapy;opioid use;opioid use disorder;Oral;pain behavior;Pain management;pandemic disease;Patient Admission;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phase;pre-clinical;preclinical development;prescription opioid;prevent;Prevention;Program Development;Reactive Oxygen Species;Receptor Activation;Regimen;response;Risk;Risk Reduction;Sedation procedure;Signal Transduction;Small Business Innovation Research Grant;small molecule;small molecule therapeutics;stimulant use disorder;Synapses;targeted treatment;Therapeutic;therapeutic candidate;therapeutic opioid;Tissues;Toxicology;trauma units;trend;Validation;Weaning;Withdrawal;Withdrawal Symptom;withdrawal-induced anxiety

PROJECT_TITLE: Development of a Novel Calcium Channel Therapeutic for Opioid Use Disorder