NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Persistent pain and hyperalgesia arising from tissue/nerve injury reflect an enhanced signaling mediated by DRG nociceptive neurons, macrophages, and spinal microglia. We now recognize that a common thread linking the enhanced responsivity associated with these three neuraxial components are cholesterol-rich lipid rafts that also express Toll-like receptor 4 (TLR4-rafts). The present studies will define the principles of TLR4raft organization in DRG neurons and macrophages, the plasticity in this organization with nerve injury and tissue inflammation; and the impact of disrupting TLR4-rafts in alleviating neuropathic and inflammatory pain.

PI_NAMEs: DOUGHERTY, PATRICK M;MILLER, YURY ;YAKSH, TONY L. (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Action Potentials;Acute;Address;Affect;Anatomy;Animals;Architecture;ATP binding cassette transporter 1;behavior test;behavioral phenotyping;Calcium;Cell membrane;Cells;Cellular Membrane;Cholesterol;chronic constriction injury;Clinical;Clinical Trials;Complex;conditioned place preference;constriction;dermatome;Diffuse;dimer;Dissociation;Dyes;Electrophysiology (science);Elements;Enzymes;Female;Fluorescence Resonance Energy Transfer;gabapentin;gain of function;Heterogeneity;Homo;Hour;Human;Hyperalgesia;in vivo;Inflammation;Inflammatory;inflammatory pain;Injury;insight;Ion Channel;Knowledge;Ligation;Link;live cell imaging;loss of function;Macrophage;male;Measures;Mechanics;Mechanoreceptors;Mediating;Membrane;Membrane Lipids;Membrane Microdomains;Methods;Microglia;Modeling;Molecular;molecular phenotype;Multicenter Studies;Mus;mutant;Nerve compression syndrome;nerve injury;Nerve Tissue;Neurobiology;neuronal excitability;Neurons;Neuropathy;Nociception;Nociceptors;Output;Paclitaxel;Pain;pain behavior;pain model;pain processing;painful neuropathy;patch clamp;Persistent pain;Phenotype;Physiological;Prevalence;Process;Property;Rattus;receptor;Resolution;Rodent;Role;Secondary to;Signal Transduction;small molecule inhibitor;Specificity;Spinal;spontaneous pain;Stimulus;Surgical incisions;System;targeted treatment;Testing;Therapeutic;Time;tissue injury;tissue trauma;Tissues;TLR4 gene;tool;Trauma;TRPV1 gene;Withdrawal;Work

PROJECT_TITLE: Role of TLR4-lipid rafts in nociception

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Social Determinants of Health;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: LOVELACE BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: NM

PHR: Project Narrative Research has shown that dysfunctional cognitive-emotion interactions undermine self-regulation in subtypes of high-risk individuals which contribute to risk for relapse to substance use and antisocial activity. Here we implement a randomized clinical trial of two cognitive remediation training programs to address these deficits and track real-world behavioral and neural change associated with these interventions.

PI_NAMEs: BASKIN-SOMMERS, ARIELLE RYAN;KIEHL, KENT A (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Accounting;Address;adjudication;Administrative Supplement;Affective;anti social;antisocial behavior;Attention;Award;Behavior;behavior change;Behavioral;behavioral outcome;Brain;callous unemotional trait;Characteristics;Clinical;Cognitive;cognitive control;Cognitive deficits;Cognitive remediation;cognitive skill;Communities;cost;Cues;Development;Disinhibition;Emotional;Emotions;executive function;Foundations;Functional disorder;functional MRI scan;high risk population;Impairment;improved;improved outcome;Individual;Informal Social Control;information processing;Institution;Intervention;Laboratories;Measures;neural;neural circuit;neuroimaging;offender;Outcome;Outcome Measure;outcome prediction;Pattern;Performance;Pharmaceutical Preparations;Pilot Projects;Prisons;Protocols documentation;Psychopath;psychopathic personality;Psychopathology;randomized, clinical trials;Reaction;recidivism;relapse risk;Research;Research Support;response;Rewards;Risk;skills;skills training;Societies;Specific qualifier value;Structure;substance misuse;substance use;Substance Use Disorder;Substance-Related Disorders;success;Symptoms;Testing;Training;Training Programs;trait;Translating;treatment effect;treatment strategy;Work

PROJECT_TITLE: Matching Treatments to Cognitive Deficits in  Offenders with Substance Use Disorders

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Pediatric;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: PARTNERSHIP TO END ADDICTION

ORG_STATE: NY

PHR: Project Narrative Internalizing disorders, primarily anxiety and depression, are highly prevalent among adolescents receiving community-based treatment for SUD; moreover, unresolved internalizing issues significantly interfere with adolescent SUD treatment and recovery. Yet, routine services for youth SUD do not systematically target internalizing disorders. The proposed study will address this quality gap by developing a modular, family-based protocol to augment routine youth SUD care by directly targeting co-occurring internalizing problems as a primary treatment goal: Family Support Protocol for Adolescent Internalizing Disorders (Fam-AID).

PI_NAMEs: HOGUE, AARON  (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Address;Adolescent;adolescent substance use;Age;Anxiety;base;Behavior;Behavioral;Behavioral Model;Benchmarking;Caregivers;Caring;Client;Clinic;Clinical;cognitive interview;Cognitive Therapy;Collaborations;community based treatment;comorbidity;Consultations;Data;design;Development;Diagnostic;Disease;Dose;Education;Elements;emotion dysregulation;emotion regulation;Emotional;Emotions;Enrollment;evidence base;Evidence based practice;Exercise;Family;Family member;family support;feasibility testing;follow-up;Fostering;Foundations;Goals;Guidelines;individualized medicine;innovation;Interruption;Intervention;Interview;Literature;Manuals;Mental Depression;Methods;Modeling;National Institute of Drug Abuse;negative affect;Outcome;Pathway interactions;Phase;prevent;Prevention;Procedures;Process;Protocols documentation;prototype;Provider;psychoeducation;Recovery;Reporting;Research;resilience;Resources;routine care;Safety;safety net;Self-Injurious Behavior;Series;Services;Site;social capital;substance use;Substance Use Disorder;Symptoms;Techniques;Teenagers;Testing;Time;Training;treatment as usual;Treatment Effectiveness;treatment planning;Treatment Protocols;treatment services;uptake;Vulnerable Populations;Youth

PROJECT_TITLE: Testing the Feasibility of a Family-based Adjunctive Treatment Protocol for Targeting Co-Occurring Internalizing Disorders among Adolescents with SUD

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Diabetes;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: AUGUSTA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Diabetic retinal microangiopathy is a key pathogenic event for the development and progression of diabetic retinopathy (DR), the leading cause of blindness in adults. We have designed studies to investigate the molecular mechanism(s) of diabetes-induced retinal endothelial cells stress-induced premature senescence (SISP) as this process, also known as inflammaging, is central to the development of the vascular pathology associated with the development of (DR). In particular, we will study the molecular and functional events associated with dysfunction of the HDAC6-SIRT-1 axis.

PI_NAMEs: BARTOLI, MANUELA  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Adult;antagonist;autocrine;Blindness;Blood Vessels;Cell Aging;Cell Physiology;Cells;Cellular Stress;Chronic;combat;Complications of Diabetes Mellitus;Data;Development;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;diabetic rat;Diabetic Retinopathy;diagnostic tool;Down-Regulation;Endothelial Cells;Endothelium;Epigenetic Process;Equilibrium;Event;exosome;extracellular vesicles;Feedback;Functional disorder;Gene Expression Regulation;Glucose;Goals;HDAC1 gene;HDAC6 gene;Heat-Shock Proteins 90;Histone Deacetylase;Homeostasis;Hyperglycemia;In Vitro;in vivo;Inflammaging;Inflammation;Inflammatory;innovation;insight;Knowledge;Link;Literature;Mediating;MicroRNAs;Microvascular Dysfunction;mitochondrial dysfunction;Molecular;Molecular Analysis;Mus;Nerve Degeneration;neurovascular;Neutrophil Infiltration;Niacinamide;non-diabetic;novel;novel diagnostics;novel therapeutics;Nucleotides;Online Systems;Outcome;overexpression;paracrine;Pathogenesis;Pathogenicity;Pathologic;Pathology;Physiological;premature;preservation;prevent;Prevention;Process;Property;Regulation;Reporting;Research Design;response;Retina;Role;senescence;senescence associated secretory phenotype;senomorphic;Signal Transduction;Signaling Molecule;SIRT1 gene;Sterility;Stimulus;Streptozocin;Stress;Supplementation;System;Testing;Therapeutic;tool;vascular stress;Vision

PROJECT_TITLE: Inflammaging and Diabetic Retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Those at-risk for bipolar disorder and those diagnosed with the disorder demonstrate significant positive emotion dysregulation (PED), and PED is related to the severity of illness, functional outcomes, and comorbid conditions. This project will use multi-method experimental behavioral and neuroimaging paradigms to examine PED among three emerging adult groups: (1) early-onset bipolar disorder diagnosis, (2) at high-risk for bipolar disorder but not yet diagnosed, and (3) at low-risk for bipolar disorder. Of import, we will conduct novel work to examine how PED can prospectively predict the onset and progression of bipolar mood symptoms across a two-year longitudinal follow-up within the early-onset and high-risk groups to predict the early onset and progression of symptoms, so as to foster development of future interventions.

PI_NAMEs: GRUBER, JUNE L (contact);JOHNSON, SHERI L

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Address;Affective;age group;Basic Science;Behavior;behavior measurement;Behavioral;Behavioral Mechanisms;Bipolar Disorder;clinical diagnosis;clinical predictors;Clinical Sciences;cognitive control;Communities;comorbidity;depressive symptoms;Development;Diagnosis;Diagnostic;Disease;disorder risk;early onset;early onset disorder;emerging adult;emerging adulthood;emotion dysregulation;emotion regulation;Emotions;follow-up;Fostering;Foundations;Functional Magnetic Resonance Imaging;functional outcomes;Future;Goals;high risk;high risk population;hypomania;indexing;Intervention;Interview;Laboratories;Laboratory Study;longitudinal design;Manic;Mental disorders;Methods;Modality;Modeling;Monitor;mood symptom;Moods;multimodality;National Institute of Mental Health;neural;neural circuit;neuroimaging;neuromechanism;novel;Onset of illness;Outcome;Parietal;Participant;Phase;Population;positive emotional state;Predictive Value;Predictive Value of Tests;Process;progression risk;prospective;recruit;Regulation;response;Rewards;Risk;Risk Factors;Risk Taking;Role;Sampling;Severities;Severity of illness;Stimulus;Symptoms;Testing;therapy development;Time;Work

PROJECT_TITLE: Positive Emotion in Bipolar Disorder Onset and Illness Course in Emerging Adults


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Hepatitis;Hepatitis - B;Immunotherapy;Infectious Diseases;Liver Disease

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: NARRATIVE  This project addresses a key translational gap in the treatment of chronic viral infections, which pose a major public health challenge with over 350 million individuals world-wide infected with human immunodeficiency virus (HIV), and hepatitis B and C viruses (HBV and HCV). By providing a more complete understanding of how the self-renewing quiescent, yet functionally poised multipotent population of TCF-1Hi stem-like CD8 T cells develop in chronic viral infections, this project will unravel novel druggable targets and immunotherapy strategies for enhancing control of chronic viral infections.

PI_NAMEs: SARKAR, SUROJIT  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Ablation;Acute;acute infection;Address;Adoptive Cell Transfers;Affinity;Agonist;anti-PD1 therapy;Anti-viral Response;Antibodies;Antigens;Bypass;Cause of Death;CD8-Positive T-Lymphocytes;cell type;Cells;Chronic;chronic infection;Clinical;clinical development;Coronavirus;COVID-19 pandemic;CRISPR/Cas technology;cytokine;Cytotoxic T-Lymphocytes;Dengue;design;Development;Engineering;Event;exhaust;exhaustion;Generations;Genes;Goals;Growth;Hepatitis B Infection;Hepatitis B Virus;Hepatitis C virus;high dimensionality;HIV;HIV Infections;Human;immune checkpoint blockade;Immune response;Immunity;immunogenic;immunopathology;Immunotherapy;Impairment;improved;in vivo;Individual;Infection;Influenza;insight;Interleukin-2;Knowledge;Lower Respiratory Tract Infection;Lymphocytic choriomeningitis virus;Maintenance;Malignant Neoplasms;Mediating;Memory;Merkel cell carcinoma;Metabolic;metabolomics;mimetics;Modeling;Molecular;new therapeutic target;novel;novel therapeutic intervention;Outcome;Pathogenesis;pathogenic virus;Pathology;Patients;Pharmacotherapy;Phenotype;Polyomavirus;Population;preconditioning;predictive marker;Production;programmed cell death protein 1;Property;Proteomics;Public Health;Publishing;recruit;Regimen;Regulation;Rejuvenation;response;Role;Sampling;self-renewal;side effect;Signal Transduction;Source;statistics;stem;stem-like cell;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;tool;transcriptomics;treatment response;treatment strategy;tumor;Viral;Virus;Virus Diseases;World Health Organization;Yellow Fever

PROJECT_TITLE: Mechanisms of T Cell Quiescence and Exhaustion

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: SAN ANTONIO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: Project Narrative This project utilizes biochemical and computational methods to study the catalytic machinery of the bifunctional enzyme KatG in Mycobacterium tuberculosis, the causative agent for tuberculosis (TB) in humans. The proposed study is beneficial to human health for two reasons. This study will help 1) fight TB by disrupting the self-defense mechanism of KatG against an increased level of hydrogen peroxide in the infected host cell and 2) boost isoniazid activation in those specific isoniazid-resistance strains due to KatG mutations by enhancing their catalytic activity towards prodrug activation instead of other functions.

PI_NAMEs: LIU, AIMIN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: 5-hydroxy-tryptophan;Active Sites;adduct;Affect;Amino Acids;Anabolism;Antitubercular Agents;assault;Binding;Biochemical;Biogenesis;biological systems;Biophysics;Body Temperature;catalase;Catalysis;Cells;Charge;chemical property;Chemicals;Chemistry;cofactor;computer studies;Computing Methodologies;Consumption;covalent bond;crosslink;Crystallography;Dedications;Defense Mechanisms;Distal;Drug Metabolic Detoxication;Drug resistance;Drug Targeting;Electronics;Electrons;Environment;Enzymes;Face;fighting;Foundations;Future;Genetic;Growth;Health;Heme;heme a;Histidine;Host Defense;Human;Hydrogen;Hydrogen Bonding;Hydrogen Peroxide;hydroxyl group;Indoles;interdisciplinary approach;Invaded;Investments;isoniazid;Isoniazid resistance;Knowledge;Learning;Ligand Binding;Macrophage;Medicine;Methionine;methyl group;Modification;Molecular;Motivation;Mutation;Mycobacterium tuberculosis;Nature;neutrophil;Nitrogen;novel;Oxidants;Oxidases;oxidative damage;Oxidative Stress;pathogen;Pathway interactions;Peroxidases;Peroxides;Pharmaceutical Preparations;Phase;Post-Translational Protein Processing;Process;Prodrugs;Proteins;protonation;resistant strain;Role;Side;Site;Site-Directed Mutagenesis;small molecule;Spectrum Analysis;Structure;Temperature;Tryptophan;Tuberculosis;tuberculosis treatment;Tyrosine;Variant;Virulence

PROJECT_TITLE: Protein-Derived Cofactor in Bifunctional Enzyme KatG from Mycobacterium tuberculosis

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: PROJECT NARRATIVE: Recent clinical trials have added radiation therapy to immune checkpoint inhibitors based on the dogma that radiation releases antigens that’s activates dendritic cells and primes CD8+ T cell responses to result in an abscopal response. However, these abscopal responses are rarely seen, perhaps due to radiation-dependent lymphocyte apoptosis. The critical knowledge gap is how different forms of radiation-induced cell death induce both anti-tumor immunity and side effects from radiation; the proposed work will inform future development of immunotherapies and radiation therapy synergy.

PI_NAMEs: MCGEE, HEATHER MICHELLE (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Abscopal effect;Address;Adoptive Transfer;Affect;Albumins;anti-tumor immune response;Antigen-Presenting Cells;Antigens;Apoptosis;apoptosis in lymphocytes;Biological Assay;Cancer Patient;career development;CD8-Positive T-Lymphocytes;Cell Death;Cell Death Induction;cell type;Cells;Clinical;Clinical Trials;Clinical Trials Design;conditional knockout;cytokine;Cytokine Receptors;Data;Dendritic Cells;Development;Distant;DNA Damage;DNA Repair;draining lymph node;ds-DNA;Equilibrium;experience;experimental study;Family;Family member;Fibrosis;Foundations;fractionated radiation;Future;Generations;Genotoxic Stress;Homeostasis;IL18 gene;Immune;immune activation;Immune checkpoint inhibitor;Immune response;Immunity;Immunooncology;Immunotherapy;improved;in situ vaccine;Inflammatory;inflammatory milieu;insight;Interleukin-1;interleukin-22;Internal Ribosome Entry Site;Investigation;Ionizing radiation;Kinetics;Knock-in;Knockout Mice;Knowledge;Lead;Liver;Liver neoplasms;lung injury;Lymphoid Cell;Lymphopenia;Measures;Mediating;member;Mentors;Modeling;Molecular;Mus;Necrosis;neoantigens;Normal tissue morphology;novel;Oncology;Organism;Organoids;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Phase;Physicians;pneumonitis and fibrosis;Positioning Attribute;programs;Pulmonary Fibrosis;Radiation;radiation effect;Radiation Fibrosis;Radiation Ionizing Radiotherapy;Radiation Oncology;Radiation Pneumonitis;radiation response;Radiation therapy;radioresistant;Regimen;Regulatory T-Lymphocyte;Reporter;Reporting;Research;Role;Scientist;side effect;skills;Stimulus;synergism;T cell response;T-Lymphocyte;Technical Expertise;Testing;Therapeutic Uses;Tissues;Training;translational study;Travel;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Tissue;Work

PROJECT_TITLE: Investigating the Role of Radiation-induced Cell Death in Innate Lymphoid Cell Activation within Unique Tumor Microenvironments


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death. Recently, checkpoint blockade has demonstrated impressive results in resectable NSCLC, however the immunogenomic determinants of response or resistance in this setting remain largely unknown. In the present study, we will leverage biospecimens obtained from an existing clinical trial of neoadjuvant PD-1 blockade in resectable lung cancer to determine the functional impact of checkpoint blockade on T cell programs and to identify molecules/pathways that could guide development of future therapies.

PI_NAMEs: SMITH, KELLIE NICOLE (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Adjuvant Chemotherapy;anti-PD-1;antigen-specific T cells;Antigens;Bar Codes;Bioinformatics;Biological Assay;Biological Markers;Biology;cancer diagnosis;Cancer Etiology;Cancer Patient;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Cessation of life;Characteristics;Clinical;Clinical Trials;Colon Carcinoma;combinatorial;Curative Surgery;cytotoxic;Data;Development;Diagnosis;differential expression;Disease;Epitopes;Excision;Future;Gene Expression;Gene Expression Profile;Genetic;Genetic Transcription;Goals;Helper-Inducer T-Lymphocyte;Human;Immune;immune checkpoint blockade;immune resistance;Immune response;Immunogenomics;improved;In Situ Hybridization;Infiltration;innovation;Intrinsic factor;Knowledge;LRRC32 gene;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Molecular;Neoadjuvant Therapy;neoantigens;Non-Small-Cell Lung Carcinoma;novel;novel strategies;Operative Surgical Procedures;Outcome;Outcome Study;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;PD-1 blockade;Persons;Phase II Clinical Trials;Population;programmed cell death protein 1;programs;Recurrence;Regulatory T-Lymphocyte;relapse prevention;Resectable;Residual state;Resistance;response;response biomarker;Role;single cell sequencing;Somatic Mutation;spatial relationship;Specificity;spectrograph;standard care;success;T cell receptor repertoire sequencing;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Time;Tissues;transcriptome sequencing;treatment response;tumor;Tumor Burden;Tumor Immunity;tumor specificity

PROJECT_TITLE: Immunogenomic determinants of response and resistance to neoadjuvant anti-PD-1 in resectable NSCLC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: LUBBOCK

ORG_NAME: TEXAS TECH UNIVERSITY

PHR: The main aim of the proposed research is to develop novel methods to improve glycopeptide enrichment, isomeric separation, identification, and quantification. This will be achieved by (1) the development of a novel mesoporous graphitized carbon liquid chromatography tandem mass spectrometry (MGC-LC-MS/MS) platform in combination with a hydrophobicity index of peptides (HIP) for better separation and identification of glycopeptide isomers; (2) the development of a 15N metabolic labeling + 18-plex tandem mass tag (TMT) method to achieve a 36-plex multiplexing and a PRM isomeric glycopeptide approach for better quantitation of glycopeptide isomers; (3) the development of novel glycopeptide derivatization methods to enhance the isomeric glycopeptides characterization and enrichment; and (4) the development of improved software and algorithms to improve automated characterization of glycopeptide isomers. Together, these proposed works will improve glycopeptide isomeric characterization. The outcomes of this proposal will provide reliable and efficient glycoproteomic platforms and algorithms for a better isomeric characterization of glycopeptides which can be employed to address biomedical issue, thus contributing to the glycoscience community.

PI_NAMEs: MECHREF, YEHIA  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: 2019-nCoV;Address;Adhesions;Aldehydes;Algorithms;Alzheimer's Disease;Amides;Amination;Amino Acids;Ammonium;analytical method;analytical tool;Area;Bacterial Adhesins;Biological;Biological Process;biological systems;Blood capillaries;Calibration;Carbon;Cations;Cell Communication;Cell Culture Techniques;Cell Differentiation process;Cell Line;Cells;Charge;Chromatography;Communities;Computer software;computerized data processing;Computing Methodologies;COVID-19;Cystic Fibrosis;Data;Degenerative polyarthritis;Dementia;Derivation procedure;Development;Diabetes Mellitus;Diagnostic;Digestion;Disease;Disease Progression;drug development;Drug Targeting;Glucose;Glutamine;Glycopeptides;Glycoproteins;glycoproteomics;glycosylation;Goals;Hydrophobicity;Immune response;improved;In Vitro;indexing;Individual;innovation;instrument;interest;Investigation;ionization;Isomerism;Label;Laboratories;Link;Liquid Chromatography;Malignant Neoplasms;Mammalian Cell;Mediating;Metabolic;metaperiodate;Methods;Monitor;novel;open source;Outcome;oxidation;pathogen;Peptides;Polysaccharides;Post-Translational Protein Processing;Process;Protein Glycosylation;Proteins;Reaction;Reagent;Reporting;Reproducibility;Research;Resolution;Sampling;Sialic Acids;Sialoglycopeptides;sialylation;Side;Sodium;Software Tools;Stable Isotope Labeling;Structure;tandem mass spectrometry;Technology;Time;Vertebral column;Virus Diseases;Work

PROJECT_TITLE: Quantitative Characterization of Glycopeptide Isomers


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE: Poor person-centered maternal care (PCMC) contributes to high maternal mortality and morbidity, directly and indirectly, through lack of, delayed, inadequate, unnecessary, or harmful care. The proposed R01 will test the effectiveness of an intervention that targets provider stress and bias to improve PCMC. The results will advance the evidence base for interventions to improve PCMC and contribute to equity in maternal and neonatal health.

PI_NAMEs: AFULANI, PATIENCE A (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: Address;Africa South of the Sahara;Automobile Driving;Behavior;behavior change;Birth;burnout;care providers;care seeking;Caring;Cessation of life;Childbirth;cost;Cost Analysis;cost effectiveness;Cost Effectiveness Analysis;Country;Cross-Sectional Studies;Data;design;Disparity;Distal;Educational Curriculum;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;Emergency Situation;Environment;Equity;Evidence based intervention;experience;Facility Controls;Feedback;Future;Ghana;Grant;Health behavior and outcomes;Health care facility;health seeking behavior;improved;Inequity;innovation;Intervention;intervention effect;Interview;Kenya;Knowledge;Leadership;low and middle-income countries;low socioeconomic status;Maternal Health;maternal morbidity;Maternal Mortality;maternal outcome;Measures;Mediation;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;Mothers;neonatal care;neonatal health;neonatal outcome;obstetric care;Outcome;Patients;peer support;person centered;Persons;Pilot Projects;preference;pregnancy related death;Prevalence;primary outcome;Process;Provider;Randomized, Controlled Trials;Research;Self Efficacy;simulation;skills;social cognitive theory;Socioeconomic Status;Stress;Surveys;System;theories;Time;Training;Trauma;Woman;Women Status;women's treatment

PROJECT_TITLE: Caring for Providers to Improve Patient Experience (CPIPE) Study

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: WASHINGTON

ORG_NAME: HOMESRENEWED VENTURES LLC

ORG_STATE: DC

PHR: PROJECT NARRATIVE There is a critical need for reproducible technology solutions for efficient, cost-effective, and quality home modifications (HM) that support older adults to live independently and safely in their homes longer (Aging in Place) irrespective of their disease and/or disability status. HomesRenewed Ventures is developing an advanced interactive mobile application that will assist contractors and handy workers in completing HM tasks by generating site-specific design specifications, installation instructions, and documentation for quality assurance. Our long-term goal is to help Americans age in their home safely and healthfully, thereby reducing health care spending and supporting independence and quality of life.

PI_NAMEs: TENENBAUM, LOUIS  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Adverse event;Age;Aging;aging in place;American;assessment application;Bathing;Client;commercialization readiness;Computer software;Construction Materials;Contractor;cost;cost effective;Data;Databases;Decision Making;design;Development;Disability status;Disease;Documentation;Effectiveness;Engineering;Ensure;environmental intervention;Evaluation;experience;Fall prevention;Feedback;Focus Groups;follow-up;Future;Goals;hazard;health management;Healthcare;Home;Home Ranges;human old age (65+);Hygiene;improved;innovation;Instruction;Intake;Intuition;Libraries;Licensing;Life;meetings;member;mobile application;Modification;novel;older adult;Outcome;Participant;Performance;Phase;Positioning Attribute;practical application;Preventive;Process;Productivity;prototype;quality assurance;Quality of life;Ramp;recruit;Reproducibility;Research;research and development;Risk Assessment;Safety;Site;Small Business Innovation Research Grant;Source;Specific qualifier value;Standardization;System;Techniques;Technology;Testing;Thermometers;Time;tool;Training;Update;usability;Validation;validation studies;Variant;Washington;Well in self;Work;Workplace

PROJECT_TITLE: Expansion and validation of novel mobile app for guiding home modifications for aging in place


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Services;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This study will utilize large and diverse registry-based samples of patients with early-onset colorectal cancer to estimate the risk of recurrence associated with clinical and sociodemographic data and characterize surveillance intensity and survivorship care needs across multiple domains using patient surveys. Using these population-based estimates of recurrence risk and patient care needs, we will then engage with clinician, patient, and caregiver stakeholders to develop and evaluate a stratified survivorship care framework and care pathways to improve care for this understudied and growing population of patients.

PI_NAMEs: SUWANABOL, PASITHORN ;WALLNER, LAUREN P (contact)

PROGRAM_OFFICER_NAME: MOLLICA, MICHELLE A

PROJECT_TERMS: Address;Adult;Affect;Age;Age Years;Cancer Survivor;cancer survivorship care;care burden;care delivery;care systems;Caregivers;Caring;Characteristics;Clinical;cohort;Colorectal Cancer;Complex;Consensus;County;Data;Data Reporting;design;Diagnosis;Disease;early onset;early onset colorectal cancer;Electronics;Endoscopy;ethnic minority;evidence based guidelines;experience;Face;Family;Family Planning;follow-up;Goals;Guidelines;Image;improved;Incidence;Individual;innovation;Kentucky;Knowledge;Life;Long-Term Effects;Los Angeles;low socioeconomic status;Malignant Neoplasms;Medically Underinsured;Medically Uninsured;Methodology;Methods;Modeling;mortality;multidisciplinary;novel;older patient;Pathology Report;Pathway interactions;Patient Care;patient engagement;patient oriented;patient population;Patient Self-Report;Patients;Pattern;personalized approach;physical symptom;Population;population based;Preventive care;Process;prognostic;Provider;psychosocial;Psychosocial Assessment and Care;Quality of Care;racial minority;Recurrence;Registries;Reporting;reproductive;response;Risk;Risk Estimate;risk stratification;Sampling;Science;service delivery;Site;sociodemographic factors;sociodemographics;stakeholder perspectives;Structure;Surveys;Survivors;survivorship;Symptom Burden;Symptoms;Testing;tumor;Veterans Health Administration;Work;young adult

PROJECT_TITLE: Risk stratified survivorship care pathways for early-onset colorectal cancer

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Precision Medicine;Prevention;Rare Diseases;Skin Cancer

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative: Cutaneous T-cell lymphomas are incurable forms of skin cancer with highly variable clinical behavior without robust genomic tests that can be used for early diagnosis or predict who will have aggressive disease. Our laboratory recently identified genetic alterations in CTCL that will offer us with a strategy for developing better diagnostic and prognostic tools. The studies in this proposal will lead to development of simple blood-based genetic assays that will improve early detection and predict their clinical behavior.

PI_NAMEs: LIM, MEGAN S. (contact)

PROGRAM_OFFICER_NAME: THURIN, MAGDALENA

PROJECT_TERMS: accurate diagnosis;Aggressive Clinical Course;Behavior;Bioinformatics;Biological Assay;Biological Markers;Biometry;Blood;chromatin remodeling;Classification;Clinical;cohort;comparative;comparative genomic hybridization;Cutaneous T-cell lymphoma;Detection;Development;Diagnosis;Diagnostic;diagnostic biomarker;diagnostic criteria;diagnostic panel;diagnostic tool;Disease;disorder risk;DNA Sequence Alteration;Early Diagnosis;Environment;Epigenetic Process;Exhibits;exome sequencing;Gene Mutation;Genetic;genome sequencing;genomic biomarker;Genomics;Goals;High-Throughput Nucleotide Sequencing;improved;indexing;Indolent;Laboratories;Learning;leukemia;Life Expectancy;Lymphoma;Measures;Methods;Modeling;mortality;Mutation;Mycosis Fungoides;Nature;Neoplasm Circulating Cells;neoplastic cell;next generation sequencing;novel;Oncogenic;Outcome;Pathogenesis;Pathway interactions;patient subsets;Patients;Pennsylvania;Performance;Peripheral;Population;Prognosis;prognostic;Prognostic Marker;prognostic significance;prognostic tool;prognostication;Prospective cohort;Recurrence;Research;Research Personnel;Retrospective cohort;risk stratification;Sampling;Sezary Syndrome;Skin;Skin Cancer;skin lesion;specific biomarkers;Staging;Subcategory;Subgroup;T-Cell Lymphoma;T-Cell Receptor;T-Cell Receptor Genes;T-Lymphocyte;targeted treatment;Testing;Time;tumor;Tumor Burden;Universities;Variant;whole genome

PROJECT_TITLE: Genomic biomarkers for cutaneous T-cell Lymphoma

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Palliative Care;Schizophrenia;Serious Mental Illness

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE/RELEVANCE Delivery of high-quality care for the 5.8 million individuals living with Alzheimer’s disease and related dementias (ADRD) is a national priority that is hindered by our lack of understanding of the ways in which comorbidities such as serious mental illness (SMI) contribute to unique care needs, symptoms, and disease burden. The proposed project will use both national data and formal caregiver perspectives to characterize the impact of having both SMI and ADRD on symptoms, disease burden, and care. The findings will be used to identify possible targets for future development and testing of person-centered interventions that address these unique needs and improve outcomes for persons with ADRD.

PI_NAMEs: BLOCK, LAURA MARIE (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Accounting;Address;Admission activity;Adult;adverse outcome;Age;Aging;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;anti-depressive agents;Antipsychotic Agents;Assessment tool;Behavior;behavioral impairment;Behavioral Symptoms;Bipolar Disorder;burden of illness;career;Caring;Characteristics;Clinical;Cognitive;comorbidity;Complex;Data;Data Set;Dementia;dementia care;design;Development;Diagnosis;Discipline of Nursing;Disease;Disease Progression;disorder risk;Distal;Educational Status;Effectiveness;Ethnic Origin;Exhibits;experience;falls;Formal caregiver;functional decline;Functional impairment;functional status;Future;Goals;Home Nursing Care;Impaired cognition;improved;improved outcome;Individual;Intervention;Interview;Knowledge;Link;Long-Term Care;Major Depressive Disorder;Managed Care;Methods;Modeling;National Institute on Aging;Nurses;Nursing Homes;older adult;Outcome;Pain;Pain management;Pattern;Perception;person centered;Persons;Pharmaceutical Preparations;Play;Prevalence;programs;Provider;Psychiatric therapeutic procedure;psychologic;psychosocial;Public Health;Quality of Care;Quality of life;Race;Research;Research Design;Research Priority;Resources;restraint;Risk;Role;Safety;Schizophrenia;Scientist;severe mental illness;sex;Shapes;skills;Social Workers;Symptom Burden;symptom management;symptomatology;Symptoms;Techniques;Testing;Training;Variant;Vulnerable Populations

PROJECT_TITLE: Characterizing Alzheimers Disease and Serious Mental Illness Co-Occurrence Among Nursing Home Residents and Relationship to Symptomatology and Care Practices

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: ATLANTA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Disease caused by viruses such as dengue, chikungunya, and dengue, which are transmitted by the Aedes aegypti mosquito, affect millions of people living in and traveling to the tropics; however, traditional approaches to mosquito control have not proven effective. We will conduct a randomized clinical trial in Merida, Mexico, to test whether application of insecticides with months of residual activity to specific mosquito resting sites in homes (targeted indoor residual spraying) reduces laboratory-confirmed cases of mosquito-borne virus infection. This work will have broad implications for how health programs around the world combat mosquito-borne viruses and set a precedent for the study and implementation of novel mosquito control interventions.

PI_NAMEs: VAZQUEZ PROKOPEC, GONZALO MARTIN (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Acute;Address;Adult;Aedes;Affect;aged;analytical tool;arm;Behavior;Censuses;chikungunya;Child;Cities;Clinical;Clinics and Hospitals;Cluster randomized trial;Collection;combat;Cox Proportional Hazards Models;Credentialing;Culicidae;Darkness;Data;Dengue;Dengue Virus;design;Discipline of Nursing;Disease;Effectiveness;egg;Endemic Diseases;Enrollment;Enzyme-Linked Immunosorbent Assay;Epidemic;Epidemiology;Evaluation;evidence base;Evidence based intervention;experience;Exposure to;Fogs;Formulation;Furniture;Health;Home;Household;Human;Human Resources;Immunoglobulin G;Immunoglobulin M;Incidence;indexing;Individual;Infection;infection rate;Insecticides;Interruption;Intervention;intervention delivery;Laboratories;Logistic Regressions;mathematical model;Measures;Methods;Mexico;Modeling;Monitor;Mosquito Control;mosquito-borne;multidisciplinary;Neutralization Tests;novel;Pediatric cohort;Persons;Pesticides;policy recommendation;Population;Predisposition;prevent;Prevention;primary endpoint;Procedures;programs;prospective;Public Health;Publishing;Random Allocation;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Residual state;response;Rest;Reverse Transcriptase Polymerase Chain Reaction;Running;Sampling;Seasons;secondary endpoint;seroconversion;Serology;serosurvey;Site;standardize measure;stem;Surface;System;systematic review;Telephone;Testing;Therapeutic;Time;Training;transmission process;Travel;trial design;Vaccines;vector control;vector mosquito;viral transmission;Virus;Virus Diseases;Visit;Work;ZIKA;Zika Virus

PROJECT_TITLE: Quanitifying the Epidemiological Impact of Targeted Indoor Residual Spraying on Aedes-borne Diseases


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Dental, Oral, and Craniofacial Disease;Microbiome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The more than 700 microbial species identified as resident in the human oral cavity live in highly organized structures, and the relationships among the species determine the community's net functions and effects on the host. These biofilms can be visualized using new imaging techniques, but statistical methods to analyze the structures and relationships are lacking. We propose to create and share such tools, which will be used to extract information that will improve disease control and prevention.

PI_NAMEs: LEE, KYU HA ;STARR, JACQUELINE R (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: 3-Dimensional;Address;Affect;Analysis of Variance;Architecture;Area;Astronomy;Bacteria;Biological;biomedical imaging;Calibration;cell type;Cells;Characteristics;Clinical;Communities;community organizations;Complex;Computer software;computerized tools;Confocal Microscopy;Data;data integration;Data Set;Dependence;Development;Dimensions;Disease;disorder control;disorder prevention;Ecology;Environment;Epithelium;Evaluation;Exhibits;experience;flexibility;Fluorescent in Situ Hybridization;Forestry;Free Will;Goals;Health;high dimensionality;Hour;Human;Image;Image Analysis;Imaging Techniques;improved;innovation;insight;Joints;Knowledge;Label;Location;Maps;Mathematics;Measures;Medical Imaging;Methods;Microbe;microbial;Microbial Biofilms;microbial community;Microbiology;microbiome;microbiome research;microorganism interaction;Modeling;Multivariate Analysis;novel;Nutrient;Oral;oral biofilm;Oral cavity;Organelles;organizational structure;Pathogenicity;Pattern;Performance;Physiology;Play;polymicrobial biofilm;Process;Radial;Recording of previous events;Role;Running;Salivary;Sampling;scale up;Site;skills;Slice;software development;Spatial Distribution;spectrograph;Statistical Methods;statistics;Structure;Surface;System;Taxon;Taxonomy;Techniques;Technology;Testing;Three-Dimensional Image;three-dimensional modeling;Tongue;tool;two-dimensional;user-friendly;virtual;Visualization;Work

PROJECT_TITLE: Bayesian multivariate 3D spatial modeling for microbiome image analysis

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE Despite advances in breast cancer prevention and therapies, Black women exhibit increasing incidence and continue to have the highest breast cancer mortality rate compared to any other racial population. Mammographic density is one of the strongest breast cancer risk factors, yet, while Black women are more likely to exhibit higher mammographic density, unique predictors of mammographic density are severely understudied in this vulnerable population. Using the Black Women’s Health Study, the largest cohort of Black women in the United States, the overall goal of this proposal is to identify life course developmental and maturation risk factors for increased mammographic density.

PI_NAMEs: BIGHAM, ZAHNA  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Address;Adult;Age;Age at Menarche;analytical tool;Asian Women;biobehavior;Biological;Biology;Biometry;Birth;black women;Body mass index;Breast;Breast Cancer Prevention;Breast Cancer Risk Factor;Breast Cancer Treatment;breast density;Breast Feeding;cancer health disparity;cancer risk;cancer therapy;career;Characteristics;Childhood;clinical training;cohort;Coupling;Data;Death Rate;density;Development;Developmental Course;Diagnosis;digital;Discrimination;Disparity;Doctor of Philosophy;emerging adult;Environment;Environmental Exposure;Epidemiologic Methods;Epidemiology;Etiology;European ancestry;Exhibits;experience;Exposure to;First Births;Funding;Future;General Population;Goals;Growth and Development function;Health Disparities Research;Healthcare Systems;Height;High birth weight infant;human old age (65+);improved;Incidence;insight;Integration Host Factors;Intervention;Investigation;Lead;Learning;Life Cycle Stages;Literature;Lived experience;Malignant Breast Neoplasm;Mammographic Density;Mammography;Mediator;Menarche;novel;obesity in children;Parents;parity;Participant;Pattern;Physicians;Population;Predisposition;Pregnancy;Prevention;Preventive healthcare;Puberty;public health intervention;Race;racial population;Recording of previous events;repository;reproductive;Reproductive History;reproductive outcome;Research;Research Personnel;Risk Factors;Risk Reduction;Sample Size;Scientist;Sexual Development;Sexual Maturation;skills;social;Social Behavior;social disparities;social health determinants;Somatotype;Structural Racism;Surrogate Endpoint;survival disparity;Techniques;Testing;Time;Training;United States;Vulnerable Populations;Waist-Hip Ratio;Weight;White Women;Woman;Women's Health;Work

PROJECT_TITLE: Life Course Developmental and Reproductive Predictors of Increased Mammographic Breast Density in Black Women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-D(20)L]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE By 2060, the burden of Alzheimer’s disease and related dementias in the U.S. is expected to double with women being overrepresented among cases, but many powerful and highly prevalent aspects of women’s lives–including exposure to gender-based violence–have received almost no attention in ADRD research. Thus, we propose to investigate the relationship between experiences of intimate partner violence and cognitive decline among cis-gender women. This work may suggest new strategies for ADRD prevention, reveal how lifecourse social experiences of women influence ADRD risk, and elucidate potential mechanisms of ADRD development.

PI_NAMEs: MURCHLAND, AUDREY ROSE (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Acceleration;Address;Adult;Age;age acceleration;Aging;aging related;Alzheimer's disease related dementia;Anxiety;Attention;Birth;Cardiovascular Diseases;career;Characteristics;childhood adversity;chronic pain;cis-female;cisgender;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive testing;cohort;Data;Data Sources;dementia risk;Development;ethnic identity;Ethnic Origin;experience;Exposure to;Fellowship;Gender;gender-based violence;Goals;Health;Health and Retirement Study;health inequalities;Impaired cognition;improved;intimate partner violence;late life;Life;Life course epidemiology;Life Cycle Stages;Literature;Measurement;Measures;Mental Depression;Mentorship;Methodology;Methods;middle age;Modeling;Modernization;Nature;Neurobiology;Neurologic;novel;Nurses' Health Study;older women;Outcome;Participant;pediatric trauma;Population;Prevention;Public Health;Race;Reporting;Research;Research Personnel;Risk;Sample Size;Sampling;Sexually Transmitted Diseases;social;Social Network;social relationships;sociodemographics;socioeconomic diversity;Socioeconomic Status;socioeconomics;Stress;Stress Tests;Subgroup;Training;Trauma;traumatic stress;violence victimization;Woman;Women's Health;Work

PROJECT_TITLE: Intimate Partner Violence and Dementia Risk: Applying Lifecourse and Gender Analysis


NIH_SPENDING_CATS: Cancer;Clinical Research;Eye Disease and Disorders of Vision;Precision Medicine;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative There is an urgent need to develop novel therapeutic options for uveal melanoma, the most common primary cancer of the eye in adults that affects more than 2,500 patients each year in the US alone, nearly 50% of which will die from metastatic disease. The recent discovery of the GNAQ uveal melanoma oncogene, which encodes GTPase deficient and constitutively active Gαq proteins has provided an opportunity to investigate its cancer promoting mechanisms. Ultimately, our planned team efforts aimed at elucidating the GNAQ-oncogenic signaling circuitry will reveal novel targeted (precision) therapies for advanced UM and metastatic UM patients and many other human diseases involving aberrant GNAQ expression and function.

PI_NAMEs: APLIN, ANDREW ERIC;GUTKIND, JORGE SILVIO  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Adult;Affect;cancer genome;cancer type;Cell Death;cell growth;Cell Line;Cell Surface Proteins;Cell Survival;Cells;Cessation of life;chemotherapy;Clinical;clinical predictors;Clinical Trials;clinically relevant;Combined Modality Therapy;computational pipelines;CRISPR screen;Cutaneous Melanoma;Cytostatics;Development;Diagnosis;Disease;Disease remission;Drug Combinations;Drug resistance;effective therapy;Event;Exposure to;Family;Foundations;Frequencies;Functional disorder;Future;G alpha q Protein;G-Protein-Coupled Receptors;gene interaction;genetic analysis;Genomics;GNAQ gene;Growth;GTP-Binding Proteins;Guanosine Triphosphate Phosphohydrolases;Human;human disease;immune checkpoint blockers;in vivo;inhibitor;Investigation;Link;Liver;malignant neoplasm of eye;Malignant Neoplasms;Melanoma;Melanoma Cell;Melanoma patient;Metastatic Melanoma;Metastatic Neoplasm to the Liver;Modeling;Molecular;molecular phenotype;Molecular Target;multidisciplinary;multimodality;Mus;mutant;Mutation;Nature;Neoplasm Metastasis;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncogenic;Pathway interactions;Patients;Pharmaceutical Preparations;Physiological;Play;Population;Positioning Attribute;Precision therapeutics;predictive marker;prevent;Primary Lesion;PTK2 gene;Refractory;Relapse;Resistance;Risk;Role;Sampling;side effect;Signal Transduction;Skin;Specificity;synergism;System;Therapeutic;therapeutically effective;Toxic effect;transmission process;treatment response;tumor;tumorigenic;Tyrosine Phosphorylation;United States;Unresectable;Uveal Melanoma;Xenograft Model

PROJECT_TITLE: Targeting Systems Vulnerabilities in the Gαq/GNAQ Oncogenic Signaling Circuitry: New Precision Therapies for Uveal Melanoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_DEPT: PATHOLOGY

PHR: Narrative The myofibroblast is a differentiated mesenchymal cell with recognized important roles in organ development, cancer and tissue repair/remodeling. By focusing on the molecular processes underlying the genesis of the myofibroblast this project will further understanding of these areas of both biological (e.g. developmental biology) and disease (e.g. cancer and abnormal healing) relevance.

PI_NAMEs: LIU, TIANJU  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Achievement;Actins;Address;Alveolar;angiogenesis;Appearance;Area;Base Excision Repairs;Binding;Binding Proteins;Biological;carcinogenesis;Cell Differentiation process;Cell division;cell type;Cells;Complex;CpG Islands;cytokine;Data;demethylation;Derivation procedure;Development;Developmental Biology;Differentiation Antigens;Dioxygenases;Disease;DNA;DNA Methylation;DNA Modification Methylases;DNA Sequence;Elements;Epigenetic Process;epigenetic regulation;epigenomics;Epithelial Cells;Extracellular Matrix;Fibroblasts;Gene Expression;Genes;Genetic Transcription;Goals;healing;Hour;Impaired healing;Impairment;In Vitro;in vivo;Lung;Malignant Neoplasms;Mediating;Mesenchymal Differentiation;Methylation;Molecular;Myofibroblast;Neoplasm Metastasis;organ growth;overexpression;oxidation;Process;programs;promoter;Protein Isoforms;Proteins;Proteomics;recruit;Regulation;repaired;response;Role;Signal Pathway;Smooth Muscle;Specificity;stem cells;Stimulus;Testing;Thymine DNA Glycosylase;Time;tissue injury;tissue repair;Tissues;transcription factor;Transgenic Mice;tumor growth;wound

PROJECT_TITLE: The role of Tet1 in myofibroblast differentiation

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Cancer research in Zambia, particularly population-based research, is limited, primarily due to a lack of well- trained investigators, supportive research infrastructure, and adequate funding. Vanderbilt University Medical Center (VUMC) and the University of Zambia (UNZA) are expanding their longstanding research training partnership to establish a new training program, the Vanderbilt-Zambia Cancer Research Training Program (VZCARE). The goal of VZCARE is to develop a cadre of researchers and educators equipped with modern knowledge and expertise to lead cancer epidemiology research and training in Zambia, to encourage US- based researchers to engage in cancer research in low- and middle-income countries, and to ensure long-term program impacts and sustainability.

PI_NAMEs: HEIMBURGER, DOUGLAS CORBETT;MUTALE, WILBROAD ;SHU, XIAO-OU  (contact)

PROGRAM_OFFICER_NAME: SIVARAM, SUDHA

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Advanced Malignant Neoplasm;anti-cancer research;Cancer Burden;cancer epidemiology;career development;Cessation of life;Collaborations;disability;Disease;Doctor of Philosophy;doctoral student;Education;Educational Curriculum;Educational workshop;Ensure;Epidemiology;epidemiology study;experience;Faculty;Fostering;Funding;Future;Goals;Health;HIV;Hospitals;investigator training;Knowledge;Lead;low and middle-income countries;Malignant Neoplasms;member;Mentors;Modernization;multidisciplinary;Population Research;Positioning Attribute;Postdoctoral Fellow;premature;programs;Research;research and development;Research Infrastructure;Research Personnel;Research Training;Scholars Program;Scientist;Teaching Hospitals;Training;Training Programs;Training Support;trend;Universities;Visit;Zambia


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The strong link between the heart and the nervous system is critical for daily living, but becomes abnormal during chronic heart disease, and is associated with risk of death. In this proposal, we will investigate whether Satellite Glial Cells, an often ignored cell type within the nervous system, plays an important role in the process by which the links between the heart and nervous system become abnormal. If involved, our study's findings will lay the groundwork for future studies that guide therapies targeting satellite glial cells.

PI_NAMEs: AJIJOLA, OLUJIMI A (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Ablation;Animals;Arrhythmia;Attenuated;beta-adrenergic receptor;Calcium Signaling;Cardiac;Cardiomyopathies;Catecholamines;Cause of Death;cell type;Chronic;Chronic Disease;chronic pain;Communication;Connexin 43;cytokine;Data;Development;Dilated Cardiomyopathy;Disease;Electrophysiology (science);Fibrosis;Functional disorder;Future;G-Protein-Coupled Receptors;Gap Junctions;Genetic;glial activation;Glial Fibrillary Acidic Protein;Goals;Health;Heart;Heart Diseases;Heart failure;Heart Injuries;Human;human data;human model;Hyperactivity;Inflammatory;Inflammatory Bowel Diseases;inhibitor;Injury;Ischemia;Left Ventricular Dysfunction;Left Ventricular Remodeling;Link;Mediating;Medical;Modeling;Morphology;mortality;mortality risk;mouse model;multidisciplinary;Mus;Myocardial Infarction;Myocardium;Nervous System;neural;neurochemistry;Neuroglia;Neuronal Dysfunction;neuronal excitability;Neurons;neuroregulation;neurotransmission;Norepinephrine;novel;organ injury;Patients;Pharmaceutical Preparations;Play;porcine model;prevent;Prevention;Process;Purines;release factor;Reperfusion Therapy;Research Personnel;Role;side effect;Signal Transduction;Signaling Molecule;Structure of stellate ganglion;Supporting Cell;Sympathetic Ganglia;Synapses;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;tool;Transgenic Mice;Up-Regulation;Ventricular Arrhythmia;Ventricular Tachycardia;Viral

PROJECT_TITLE: Satellite Glial Cell Activation and Sympathetic Imbalance in Cardiomyopathy and Arrhythmias

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE/RELEVANCE Deregulation of cullin–RING ubiquitin ligase (CRL) complexes contributes broadly to human disease, including cancer, infectious diseases, sleep disorders, metabolic diseases, degenerative neurologic disorders, etc. Notably, thalidomide and other imids, which repurpose specific cellular CRL complexes to degrade neo-substrates, have shown clinical success. The major goal of our research is to determine how CRL complexes control essential biological processes at the cellular and organismal levels, revealing yet unknown mechanisms and new therapeutic strategies for a wide range of human diseases.

PI_NAMEs: PAGANO, MICHELE  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Area;Autophagocytosis;Biochemical;Biological;Biological Process;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Physiology;Cell Proliferation Regulation;Cells;circadian pacemaker;Clinical;Communicable Diseases;Complex;Cullin Proteins;Dimensions;DNA Damage;DNA Repair;Enzymes;Etiology;field study;Genetic;Goals;human disease;immune modulating agents;in vivo evaluation;insight;interdisciplinary approach;interest;Laboratories;Life;Light;Malignant Neoplasms;Mammalian Cell;Mammals;Mediating;Metabolic Diseases;Molecular;multicatalytic endopeptidase complex;Neurodegenerative Disorders;New Territories;novel therapeutic intervention;Oncology;Play;Process;Proliferating;Proteomics;Regulation;Research;response;Role;Signal Transduction;Signal Transduction Pathway;Sleep Disorders;success;System;Thalidomide;Ubiquitin;ubiquitin ligase

PROJECT_TITLE: Regulation of the cell proliferation by CRL ubiquitin ligases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Dengue is the most significant mosquito-transmitted virus that infects humans. In clinical trials, a leading live attenuated dengue virus vaccine was observed to be poorly efficacious and unsafe in some children. We propose to use computational tools to design dengue envelope protein subunit vaccines and evaluate their safety and efficacy in mouse models of vaccination.

PI_NAMEs: DESILVA, ARAVINDA M. (contact);KUHLMAN, BRIAN A

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Antibodies;Antibody Response;Attenuated;B-Lymphocytes;Binding;biophysical properties;Cell secretion;Child;Clinical Trials;computerized tools;Computing Methodologies;cross reactivity;Culicidae;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Dengvaxia;design;dimer;Disease;e Antigens;E protein;env Gene Products;Epitopes;Exposure to;Flavivirus;Goals;Human;Immune response;Immunity;Immunize;immunogenicity;immunological status;Infection;Length;Mammalian Cell;Membrane;Membrane Proteins;molecular modeling;monomer;mouse model;Mus;Mutate;neutralizing antibody;novel;particle;Persons;Physiological;Placebos;preservation;Process;Production;protein folding;Protein Secretion;Proteins;public trust;Recombinant Proteins;recombinant virus;Recombinants;Research;response;Rest;Risk;Safety;Serotyping;severe dengue;Severity of illness;Specificity;stability testing;Structure;Subunit Vaccines;success;Surface;Techniques;Testing;Vaccination;vaccination strategy;Vaccine Antigen;vaccine candidate;Vaccine Design;vaccine development;Vaccines;Variant;viral transmission;Virion;Virus;Virus Diseases;virus envelope;Virus Replication;Virus-like particle

PROJECT_TITLE: Structure based design of dengue subunit vaccines for inducing protective but not disease enhancing antibodies

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common monogenic kidney disease and the fourth cause of renal failure among adults, with close to $3.5 billion spent annually on the treatment of patients in the US alone. Yet there remain tremendous challenges in several facets of the disease, including the need for additional therapies to delay disease progression and identification of early disease specific biomarkers to assess disease severity, monitor disease progression and a treatment effect, from early stages of the disease. The findings resulting from this study will: 1) advance the understanding in the pathophysiology of ADPKD, 2) may identify novel biomarkers, and 3) point out additional mechanisms that could be target for therapeutic intervention.

PI_NAMEs: IRAZABAL, MARIA V (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Address;Adult;Amino Acids;Animal Model;Animals;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;arterial tonometry;Autosomal Dominant Polycystic Kidney;Basic Science;Betaine;Bilateral;Biological;Biological Markers;Blood capillaries;Blood Pressure;blood pressure elevation;Blood Vessels;Clinical Trials;cost;Cyst;Cystic kidney;Data;Development;Disease;Disease Progression;Down-Regulation;Early identification;Early treatment;Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;Epithelial Cells;Evaluation;Functional disorder;Healthcare Systems;Histological Techniques;Homocysteine;Hypertension;Imaging Techniques;In Vitro;in vivo;indexing;Injury;Intervention;Kidney;Kidney Diseases;Kidney Failure;kidney preservation;Longitudinal Studies;Metabolism;Modeling;Modification;Monitor;Mus;NADPH Oxidase;new therapeutic target;Nitric Oxide;Nitric Oxide Synthase;normotensive;novel marker;Outcome;Oxidation-Reduction;Pathology;Patients;Peripheral;pharmacologic;Phenotype;PKD2 gene;Plasma;Play;pre-clinical;preservation;prognostic value;Rattus;Regulation;renal epithelium;Renal function;Reporting;Role;Severities;Severity of illness;specific biomarkers;Sulfhydryl Compounds;targeted biomarker;targeted treatment;Techniques;Testing;Therapeutic Intervention;treatment effect;treatment response;Tubular formation;Up-Regulation;Urine;vascular abnormality;Vascular remodeling;vasoconstriction;Vasodilation

PROJECT_TITLE: Role of homocysteine metabolism, endothelial function and microvascular rarefaction on renal disease severity and progression in ADPKD

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive and fatal disease that affects ~180,000 Americans. To date there are very limited treatment options for IPF with many patients requiring lung transplantation as the last resort. Our lab has identified a activation of Sineoculis homeobox homolog 1 (SIX1) and its co-factor eyes absent homolog (EYA) in IPF; however how the SIX1/EYA1 axis modulates lung fibrosis is not known and will be studied in this proposal.

PI_NAMEs: KARMOUTY-QUINTANA, HARRY  (contact)

PROJECT_TERMS: Adult;Affect;age related;alveolar epithelium;alveolar type II cell;American;Attenuated;autocrine;Biological Assay;Bleomycin;Cell Aging;Cell Proliferation;Cell Separation;Cells;Chronic;Cilia;Clinical;cofactor;Complex;Cre lox recombination system;Data;Defect;Deposition;Development;Disease;Disease Progression;DNA Damage;Drug Approval;Embryo;Epithelial Cells;epithelial injury;Epithelium;Etiology;Experimental Models;Extracellular Matrix;Eye;Family;Fibroblasts;Fibrosis;Functional disorder;gain of function;Genes;Genetic Transcription;Homeobox;Homologous Gene;Human;Hyperplasia;idiopathic pulmonary fibrosis;Immunohistochemistry;improved;In Vitro;in vivo;Inflammatory;Injury;Interstitial Lung Diseases;Link;loss of function;Lung;lung development;lung injury;Lung Transplantation;Malignant Neoplasms;Mediating;Mediator;member;Mesenchymal;Messenger RNA;Modeling;Mus;Mutation;nintedanib;novel;novel therapeutics;Organogenesis;overexpression;paracrine;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Pirfenidone;Prevalence;prevent;Process;Production;Prognosis;Proliferating;Protein Isoforms;Proteins;Pulmonary Fibrosis;pulmonary function;Pulmonary Surfactant-Associated Protein C;Role;senescence;senescence associated secretory phenotype;Signal Transduction;Structure of thyroid parafollicular cell;Techniques;Telomere Length Maintenance;TERF1 gene;Testing;transcription factor;Type II Epithelial Receptor Cell;Up-Regulation

PROJECT_TITLE: Sineoculis Homeobox Homolog 1 (Six1) in Pulmonary Fibrosis


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Our study focuses on improving measurement as well as prevention of complications that patients experience related to routinely placed tubes called urinary catheters to empty the bladder during and after surgery; urinary catheters are among the most commonly used medical devices in the world with an estimated 100 million indwelling catheters sold annually worldwide and one-quarter million sold in the United States, but urinary catheters’ risks have not been well studied. Although infections related to urinary catheters are getting more attention recently due to Medicare-required public reporting and hospital penalties, there is less recognition that non- infectious complications related to the trauma of catheter placement and removal are as common as urinary tract infections – and often have long-lasting consequences for patients with abnormal bladder emptying and discomfort. This study is being performed to develop better tools to measure and reduce perioperative urinary catheter use, as well as related post- operative urinary retention and urinary catheter complications.

PI_NAMEs: MEDDINGS, JENNIFER ANN (contact)

PROGRAM_OFFICER_NAME: MILLER, MELISSA

PROJECT_TITLE: Improving the Safety of Surgical Patients by Addressing Urinary Catheter Use, Urinary Retention, and Catheter Injury

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Bioengineering;Biotechnology;Genetics;Osteoarthritis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: VAIL

ORG_NAME: STEADMAN PHILIPPON RESEARCH INSTITUTE

PHR: L. PROJECT NARRATIVE We have established chemically defined culture methods for deriving embryonic joint progenitor-like cells that preferentially form cartilage, showing signs of permanent, articular-like cartilage, from human pluripotent stem cells. The proposed study will elucidate the underlying mechanisms of this process, by defining genes essential for the genesis of joint progenitors and progression from them to articular cartilage, using cellular molecular genetics, genomics, tissue engineering, and transplantation technologies, and then the generated information will be applied to studies of clinically relevant human adult stem cells, in order to verify that we are also able to regenerate articular cartilage efficiently from adult cells. The proposed research will thus provide the foundation for basic research towards understanding the mechanisms of articular cartilage formation, leading to a novel therapeutic method for joint cartilage repair.

PI_NAMEs: NAKAYAMA, NAOKI  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Adult;adult stem cell;Aging;Antibodies;articular cartilage;Basic Science;Bioinformatics;Biological Assay;Candidate Disease Gene;candidate validation;Cartilage;cartilage development;cartilage regeneration;cartilage repair;cartilage transplantation;cartilaginous;cell type;Cells;Characteristics;Chemicals;Chondrocytes;Chondrogenesis;clinically relevant;comparative;CRISPR/Cas technology;Cyclic AMP;Degenerative polyarthritis;Disease;Dose;Embryo;Embryonic Development;Epiphysial cartilage;Exhibits;Forskolin;Foundations;functional restoration;GDF5 gene;Gene Modified;Genes;genome-wide;Genomics;Health;human adult stem cell;human pluripotent stem cell;Hypertrophy;Immunocompromised Host;Impairment;Implant;In Vitro;in vivo;inhibitor;injured;Injury;insight;joint injury;Joints;Knee;knockout gene;Mesenchymal;mesenchymal stromal cell;Methods;mineralization;Molecular;Molecular Genetics;Molecular Target;Mus;Natural regeneration;novel;novel therapeutic intervention;novel therapeutics;overexpression;paracrine;Paracrine Communication;parathyroid hormone-related protein;Patients;physical property;Physiologic Ossification;Process;Production;progenitor;Property;Proteins;Receptor Gene;regenerative therapy;Regulation;Regulator Genes;repaired;Research;Rodent Model;Signal Pathway;Signal Transduction;Site;small molecule inhibitor;stem cells;stem-like cell;success;Techniques;Technology;Testing;Therapeutic;therapeutically effective;Tissue Engineering;tissue repair;Tissues;transcription factor;transcriptome sequencing;transcriptomics;Transplantation;Validation;Vision

PROJECT_TITLE: Articular Cartilage Tissue Engineering with Human Pluripotent Stem Cells

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Hepatic stellate cells are the main fibrogenic cell types of the liver, promoting the deposition of extracellular matrix and the progression to fibrosis and cirrhosis in many different types of liver disease. Our proposal will investigate protective and fibrosis-independent functions of hepatic stellate cells, focusing on their role in the regulation of liver injury and regeneration. For this we will combine mice with selective depletion or knockout of hepatic stellate cells in conjunction with in vitro models and novel single cell-sequencing based bioinformatic approaches.

PI_NAMEs: SCHWABE, ROBERT F. (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acute;acute liver disease;Affect;Anatomy;Bioinformatics;candidate identification;Cell Communication;Cell Death;Cell Physiology;Cell secretion;cell type;Cells;Cessation of life;chronic liver disease;Cirrhosis;Clinical Trials;Coculture Techniques;Collagen;Complex;cost;Data;Deposition;Development;Disease;Disease Progression;Endothelial Cells;Esters;Extracellular Matrix;Fibrosis;Functional disorder;functional restoration;Gene Deletion;Genetic;Hepatic;Hepatic Stellate Cell;Hepatocyte;hepatocyte injury;Homeostasis;in vitro Model;in vivo;injured;Injury;insight;Knock-out;Kupffer Cells;Ligands;Link;Liver;liver cell proliferation;liver development;Liver diseases;Liver Fibrosis;liver injury;Liver Regeneration;Long-Term Effects;Macrophage;Mechanics;Mediator;Metabolism;Mus;Myofibroblast;Natural regeneration;nonalcoholic steatohepatitis;novel;novel therapeutics;Outcome;Partial Hepatectomy;Pathogenicity;Pathologic;Pathway interactions;Patients;Perisinusoidal Space;Physiological;Positioning Attribute;Proliferating;receptor;Regulation;response to injury;Role;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Testing;Therapeutically Targetable;Tissues;tool

PROJECT_TITLE: Protective and fibrosis-independent functions of hepatic stellate cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-J(04)]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Brown adipose tissue (BAT) is an essential regulator of energy balance and glucose homeostasis. Human genetic variants in ankyrin-B, a scaffolding protein expressed in several metabolic tissues, including brown adipose tissue, lead to increased risk of metabolic diseases such as obesity and type 2 diabetes (T2D). This project will investigate the role of ankyrin-B in glucose uptake and fatty acid synthesis in BAT, as a likely mechanism underlying dysregulation of lipid metabolism, energy balance, and systemic metabolic homeostasis caused by ankyrin-B deficiency in BAT and will further our knowledge of BAT physiology and the contribution of deficits in BAT function to the development of obesity and T2D.

PI_NAMEs: AGUILLARD, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Adipocytes;Adipose tissue;Adrenergic Agents;Age;Aging;ANK2 gene;Biochemical;Bioenergetics;Biological Assay;blood glucose regulation;Body Composition;Brown Fat;Carbon;career;cell type;Cells;Clathrin;Complex;Consumption;Coupling;Cytoskeleton;Diet;energy balance;Energy Metabolism;Exhibits;fatty acid-binding proteins;Fatty Acids;Fatty-acid synthase;Fractionation;Gases;genetic variant;Glucose;glucose metabolism;Glucose Transporter;glucose uptake;Goals;Health;High Fat Diet;Homeostasis;Human;Human Genetics;Image Analysis;Impairment;in vivo;Indirect Calorimetry;insight;Insulin;Insulin Resistance;Isotopes;Knock-in Mouse;Knockout Mice;Knowledge;Lead;Light;Link;lipid biosynthesis;lipid metabolism;lipidomics;Lipids;live cell imaging;Magnetic Resonance Imaging;Membrane Proteins;Metabolic;Metabolic Diseases;Metabolic dysfunction;Microscopy;Molecular;Mus;Neonatal;Non obese;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity development;Oxygen Consumption;Peripheral;Physiology;Play;Predisposition;Proteins;Regulation;Reporting;Research Personnel;response;Risk;Risk Factors;Rodent;Role;Scaffolding Protein;skills;stressor;Surface;Testing;Thermogenesis;Tissues;Training;Up-Regulation;Variant;western diet;Work

PROJECT_TITLE: A mechanism of lipid accumulation in brown adipose tissue


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Primary Health Care;Substance Misuse

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Despite clear evidence of the benefit of integrated care for HIV and opioid use disorder on both HIV and opioid use disorder related outcomes, there is a gap between the evidence and “real- world” practices. The objectives of this proposal are to understand the barriers to integrated care from the patient, provider, clinic, and governmental level in New Jersey and to evaluate the effectiveness of an implementation strategy, that uses coaching and a collaborative learning environment, to help clinics adopt an integrated care model for HIV and opioid use disorder treatment. It is expected that the findings from this project will contribute valuable information about the impact and mechanisms by which implementation science strategies improve the quality of health care delivery to people with HIV and opioid use disorder.

PI_NAMEs: NYAKU, AMESIKA  (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Action Research;addiction;Address;Administrator;Adopted;Adoption;Aftercare;AIDS prevention;antiretroviral therapy;Area;Biometry;care systems;Caring;Clinic;cluster randomized design;Cluster randomized trial;Communicable Diseases;Communities;contextual factors;County;design;educational atmosphere;effectiveness evaluation;Elements;Epidemic;epidemic preparedness;Evaluation;evidence base;Evidence based practice;experience;Funding;Goals;Government;Health;health care delivery;health care quality;Health Services;Health Services Accessibility;Health Services Research;Hepatitis C Transmission;Hepatitis C virus;HIV;HIV/HCV;implementation framework;implementation outcomes;implementation science;implementation strategy;improved;improved outcome;Infection;Injections;integrated care;interest;International;Knowledge;Learning;Measurable;medication for opioid use disorder;Medicine;Mentors;Mentorship;Meta-Analysis;Methadone;Methods;Modeling;mortality;National Institute of Drug Abuse;new epidemic;New Jersey;Opioid;opioid epidemic;opioid treatment program;opioid use disorder;Outcome;Patients;Persons;Physicians;Positioning Attribute;Prevention;primary health service;process improvement;programs;Provider;Recommendation;Reporting;Research;research and development;Research Personnel;Research Project Grants;scale up;Scientist;service providers;Services;Site;skills;Source;substance use;Substance Use Disorder;syndemic;systematic review;Training;Training Programs;Translating;transmission process;treatment services;trial design;Use Effectiveness;Work

PROJECT_TITLE: Implementing Integrated Services for People With HIV and Opioid Use Disorder

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Chronic Pain;Genetics;Mental Health;Neurosciences;Pain Research

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Ion channels are the targets of drugs used to treat pain, epilepsy, mood disorders, hypertension, and arrhythmia. Our work aims to understand the fundamental mechanisms that control the function of a family of ion channels, known as K2Ps, that are involved in thermal, mechanical, and chemical sensing and to develop and understand the mechanisms of action of novel reagents that affect channel function. Such knowledge and reagents have direct relevance for development of more efficacious treatments of nervous system and cardiovascular disorders.

PI_NAMEs: MINOR, DANIEL L (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Address;Affect;Amines;Anesthetics;Arrhythmia;Behavior;Binding;Binding Sites;Biochemical;Biological;Biology;Biophysics;Brain;Cardiovascular Diseases;Cardiovascular system;Cells;Chemicals;chronic pain management;Complex;computer studies;Cryoelectron Microscopy;design;Development;dimer;Disulfides;Drug Targeting;Drug usage;efficacious treatment;Electrophysiology (science);Elements;empowerment;Engineering;Environment;Epilepsy;extracellular;Family;Family member;Foundations;Genes;Genetic;genetic approach;Goals;Heart;Human;human disease;Hypertension;in vivo;insight;interdisciplinary approach;invention;Investigation;Ion Channel;Ions;Knowledge;Lipid Binding;Lipids;Maps;Mass Spectrum Analysis;Measurement;mechanical force;Mechanics;member;Membrane;Membrane Proteins;Mental Depression;Modality;Modeling;Molecular;Molecular Conformation;molecular dynamics;Mood Disorders;Moods;Mutagenesis;mutant;nanodisk;nanomolar;Nature;Nervous System;neuronal excitability;novel;novel therapeutics;Pain;particle;Pharmacology;Physiology;Play;Potassium;Potassium Channel;potassium ion;preference;pressure;Process;Property;Protein Engineering;Reagent;response;Role;Ruthenium;sensory system;SF1;Signal Transduction;simulation;Site;small molecule;Stimulus;Stroke;Structure;targeted treatment;Temperature;Testing;Therapeutic Agents;tool;Work;X-Ray Crystallography

PROJECT_TITLE: Genetic and chemical biological studies of K2P structure, function, andmodulation

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PI_NAMEs: PICCIRILLO, JAY F. (contact)

PROGRAM_OFFICER_NAME: GANNOT, GALLYA

PROJECT_TERMS: Acceleration;Address;Ally;Area;Assessment tool;Award;Bibliography;biomedical informatics;brass;career development;Clinical;Clinical Research;Clinical Sciences;clinical training;clinical translation;Colorado;Comb animal structure;Communities;community engagement;Competence;Computer software;Data;Development;Dissemination and Implementation;dissemination science;diversity and inclusion;Doctor of Philosophy;doctoral student;Educational Curriculum;Educational process of instructing;Entrepreneurship;Environment;Evaluation;experience;Faculty;faculty mentor;fighting;Funding;Future;Goals;Health;health assessment;health equity;Health Sciences;Home;implementation science;improved;informatics training;Infrastructure;innovation;insight;Institution;Intellectual Property;interest;International;Internet;Investments;life span;medical schools;Medical Students;Mentors;Mentorship;Methods;Modeling;multidisciplinary;National Research Service Awards;news;open source;Pathway interactions;personalized learning;Physicians;Population;Postdoctoral Fellow;Poverty;pre-doctoral;Program Development;programs;Recommendation;recruit;Report (document);Reporting;Research;Research Infrastructure;Research Personnel;Research Support;Research Training;Review Literature;Science;Scientist;Self Assessment;social media;Stream;Structural Racism;success;symposium;Technology Transfer;Time;tool;Training;training opportunity;Training Programs;translational impact;Translational Research;translational scientist;Universities;ward;Washington;Work

PROJECT_TITLE: Washington University Institute of Clinical and Translational Sciences (TL1)


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Development of the proposed statistical method will advance scientific understanding of the associations between highly variable temporal changes in psychological states and allow for assessment of the impact of a given intervention on vulnerability to smoking lapses. By increasing understanding of the factors that trigger smoking lapses, knowledge generated by this method will also enhance development of effective interventions. This novel methodology can be used to analyze data generated from mobile health studies in a variety of different settings beyond smoking cessation, and thus has the potential to contribute to fundamental understanding of dynamic risk factors relating to drug use and other chronic disorders.

PI_NAMEs: ABBOTT, MADELINE  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: adaptive intervention;Algorithms;analytical method;analytical tool;Behavioral;Biometry;brief intervention;career;Characteristics;Chronic Disease;Clinical Trials;Collection;Complex;Computer Models;Data;Data Analyses;Data Analytics;design;Development;Dimensions;Drug usage;Ecological momentary assessment;Educational workshop;effective intervention;Emotions;Ensure;Event;evidence base;experience;flexibility;Funding;Future;Gender;Goals;Health;Health Technology;improved;Income;Individual;insight;interest;Intervention;Joints;Knowledge;Link;Measures;Mentorship;Methodology;Methods;mHealth;Michigan;Modeling;Motivation;National Institute of Drug Abuse;negative affect;novel;oral communication;Outcome;Pattern;Persons;Process;psychologic;Randomized;randomized trial;Recurrence;Research;Research Personnel;Risk;Risk Factors;Science;Scientific Advances and Accomplishments;skills;Smoker;Smoking;smoking cessation;social;Source;Statistical Methods;Statistical Models;Stochastic Processes;Substance Use Disorder;sustained recovery;symposium;theories;Time;time use;tool;Training;treatment effect;Universities;user-friendly;Variant;Work;Writing

PROJECT_TITLE: Joint longitudinal and survival models for intensive longitudinal data from mobile health studies of smoking cessation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Hippocampal dysfunctions, which arise in the course of aging, mental illnesses (major depression, schizophrenia), neurological disorders (epilepsy) or neurodegenerative diseases (Alzheimer’s and Parkinson’s), can lead to impairment of navigation and spatial attention. Little is known about the link between spatial attention and hippocampal spatial codes, primarily because it is difficult to track moment-to-moment changes in attention in traditional research animals. The proposed experiments will bridge this gap by using novel technologies and new experimental paradigms in echolocating bats, which enable measurement of attentional shifts on a rapid timescale, to elucidate how spatial attention modulates hippocampal spatial codes—a key open question in the neurobiology of navigation.

PI_NAMEs: MOSS, CYNTHIA F (contact);ULANOVSKY, NACHUM

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: 3-Dimensional;Acoustics;active control;Aging;Alzheimer's Disease;Animal Experimentation;Animal Model;Animals;Attention;attentional modulation;Auditory;Behavior;Birds;blind;Brain;Brain region;Callithrix;Canes;Cells;Chiroptera;Clinical;Code;Cognitive;Complex;design;directed attention;Echolocation;Environment;Epilepsy;Exhibits;experimental study;fly;Flying body movement;Food;Foundations;Functional disorder;Future;gaze;Health;Hippocampus;Home;Human;Impairment;innovation;insight;Knowledge;light weight;Link;Location;Major Depressive Disorder;Mammals;Maps;Measurement;Measures;Medical;Medical Device;Memory;Mental disorders;meter;millisecond;miniaturize;miniaturized device;Monitor;Multimedia;Nervous System Disorder;neural;Neurobiology;Neurodegenerative Disorders;Neurologic Deficit;Neurons;Neurosciences;new technology;novel;Parkinson Disease;Patient Monitoring;place fields;Positioning Attribute;Research;Rewards;Rodent;Schizophrenia;Signal Transduction;social;sonar;sound;spatial memory;Speed;Structure;Symptoms;System;Technology;Testing;Tongue;Training Programs;Travel;way finding;wireless;wireless electronic;Work

PROJECT_TITLE: Auditory-based navigation: attentional shifts rapidly modulate hippocampal codes

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Networking and Information Technology R&D (NITRD)

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Narrative Our research focuses on molecular interactions, and we develop methods for protein-protein docking and the characterization of ligand binding properties of proteins. Predictive tools for these applications will be substantially improved by integrating classical biophysical approaches with sequence, structure, and interaction information on biological macromolecules, and by utilizing the unprecedented availability of computer power. The methods will be implemented as web-based servers for use by the biomedical research community.

PI_NAMEs: VAJDA, SANDOR  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Antibodies;Area;Binding;Binding Proteins;Binding Sites;Biological;Biomedical Research;biophysical techniques;Cells;Communication;Communities;Computer software;Computers;Data;design;Docking;Elements;Epitopes;Escherichia coli;experimental study;flexibility;Free Energy;functional group;Goals;Hot Spot;Human;improved;interest;Ligand Binding;Ligands;Machine Learning;macromolecule;Mass Spectrum Analysis;Methods;Modeling;Molecular Probes;molecular recognition;molecular size;Multiprotein Complexes;neural;novel;Online Systems;pharmacophore;predictive tools;preference;Property;Protac;Protein Analysis;protein degradation;protein metabolite;protein protein interaction;Protein Region;Proteins;Research;Sampling;simulation;Site;small molecule;Structure;Surface;Testing;tool

PROJECT_TITLE: Analysis and Prediction of Molecular Interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

PHR: PRPOJECT NARRATIVE The NRAS gene is frequently mutated in leukemia and other human cancers. These mutations lead to the production of over-active N-Ras proteins that are very difficult targets for drug development. The overall goal of this project is to test a novel strategy for inhibiting the mutant N-Ras proteins found in cancer cells by blocking enzymes that regulate where N-Ras is located in cells and its biochemical output.

PI_NAMEs: SHANNON, KEVIN M. (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Adult;Alleles;Antineoplastic Agents;Biochemical;Biochemistry;Biological Availability;Biological Models;Biology;cancer cell;Cancer Cell Growth;candidate validation;Cell Line;Cell membrane;Cells;Chemical Actions;Chemicals;Co-Immunoprecipitations;Collaborations;Complex;conditional mutant;CRISPR interference;Cysteine;Data;Development;drug development;drug discovery;Drug Targeting;Enzymes;Exhibits;experimental study;Family;Funding;Genotype;Goals;GOLGA7 gene;Growth;Hematologic Neoplasms;Human;in vivo;Individual;inhibitor;innovation;Knock-in Mouse;Knowledge;Lead;leukemia;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Modeling;Molecular;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Myelogenous;Normal tissue morphology;novel;novel strategies;novel therapeutic intervention;NRAS gene;Oncogenic;Output;palmitoylation;Pathway interactions;pre-clinical;Pre-Clinical Model;Production;Property;Protein Isoforms;Proteins;RAS driven cancer;RAS genes;ras GTPase-Activating Proteins;RAS inhibition;Ras Inhibitor;ras Proteins;Reaction;Research Personnel;Role;Serine Hydrolase;Signal Transduction;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic target;trafficking;transcriptome;Transferase;Xenograft procedure

PROJECT_TITLE: Selectively Targeting Oncogenic NRAS in Cancer


NIH_SPENDING_CATS: Cooley's Anemia;Genetics;Hematology;Orphan Drug;Rare Diseases;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CLEVELAND STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Sickle cell anemia and β-thalassemia are among the most common inherited disorders, whose clinical symptoms can be ameliorated by increasing the levels of fetal hemoglobin (HbF). We have identified Pumilo-1 (PUM1), an RNA binding protein with no previously reported functions in erythropoiesis, as a post-transcriptional regulator of hemoglobin switching. The proposed studies will determine if modulating PUM1 can be employed as a potential therapeutic strategy for fetal hemoglobin induction.

PI_NAMEs: GNANAPRAGASAM, MERLIN NITHYA (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: 3' Untranslated Regions;Adult;Affect;alpha Globin;Anemia;Area;beta Globin;beta Thalassemia;Binding;Binding Sites;Birth;Cell Cycle;Cells;Chromatin;Clinical;clinically relevant;Collaborations;CRISPR/Cas technology;Cytoplasm;Data;disease phenotype;effective therapy;epigenetic regulation;Erythrocytes;Erythroid;Erythroid Cells;erythroid differentiation;erythroid Kruppel-like factor;Erythropoiesis;fetal;Fetal Hemoglobin;Flow Cytometry;gamma Globin;Gene Silencing;Genes;Genome;genome editing;genome-wide analysis;Globin;Hemoglobin;Hemoglobin concentration result;Hereditary Disease;Heterozygote;Human;Impairment;Individual;knock-down;lentivirally transduced;Mediating;Messenger RNA;Molecular;mRNA Stability;mRNA Translation;Mutation;New York;novel;Nuclear;Oxygen;Patients;Physiological;Post-Transcriptional Regulation;posttranscriptional;Process;progenitor;programs;Proliferating;promoter;Proteins;Protocols documentation;Regulatory Element;Reporting;Research;RNA;RNA Binding;RNA Recognition Motif;RNA-Binding Proteins;Role;Sickle Cell Anemia;Sickle Cell Trait;sickling;Site;Symptoms;Testing;Therapeutic;therapeutic target;Time;transcription factor;Transcriptional Regulation;transcriptome sequencing;treatment strategy

PROJECT_TITLE: Investigating PUM1 mediated post-transcriptional regulation of human hemoglobin switching and erythropoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The striatum is a brain structure that plays an essential role in action control, reward and decision making, and its dysfunction is associated with neuropsychiatric disorders. We aim to employ modern optical measurement technologies to visualize and investigate the precise neuromodulator releases and subcellular signaling events involved in locomotion in behaving mice. We expect that our study will lead to a deeper understanding of neuromodulatory mechanisms underlying striatal function and locomotion control, which will in turn lead to an increased understanding of neuropsychiatric diseases associated with striatal dysfunction.

PI_NAMEs: ZHONG, HAINING  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Acute;Adenosine;ADORA2A gene;Affect;Animal Behavior;Animals;antagonist;Astrocytes;Basal Ganglia;Behavior;Behavioral;Brain;Calcium;Cell Nucleus;cell type;Cells;Concentration Camps;Corpus striatum structure;Coupled;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Decision Making;Dimensions;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;Electrophysiology (science);Equilibrium;Event;Exhibits;extracellular;Fiber;Functional disorder;Ganglia;Genetic;genetic approach;Huntington Disease;Image;imaging capabilities;in vivo;indexing;Intention;Kinetics;Knock-out;Knowledge;Learning;lens;Locomotion;Measurement;Mediating;Modality;Modernization;Monitor;Motor;motor control;motor learning;mouse genetics;Movement;Mus;Needles;Nervous System Disorder;Neuroglia;Neuromodulator;neuronal excitability;Neuronal Plasticity;Neurons;neuropsychiatric disorder;neuroregulation;Optics;optogenetics;Output;Parkinson Disease;Pathway interactions;pharmacologic;Phosphotransferases;Photometry;PKA inhibitor;Play;Property;Proteins;Purinergic P1 Receptors;Resolution;response;Rewards;Role;Running;selective expression;sensor;Signal Transduction;Source;Specificity;Structure;System;Technology;Testing;tool;Translating;treadmill;Visualization

PROJECT_TITLE: Neuromodulation in the striatum

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]