ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Depression;Mental Health;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: WACO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BAYLOR UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Alzheimer’s Disease and Related Dementia (ADRD) spousal caregivers often endure a period of “living bereavement” before the death of their partner, putting them at risk for morbidity and mortality. Thus, the development of evidence-based interventions for ADRD spousal caregivers aimed at mitigating the negative health consequences associated with grief is a critical public health concern. The proposed project will (1) identify opportunities for targeted treatment and potential barriers to a tailored intervention, and (2) develop an internet-based cognitive-behavioral writing intervention for ADRD Spousal Caregivers.

PI_NAMEs: LEROY, ANGIE S (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Behavior;Behavioral;Behavioral Model;Bereavement;biobehavior;Biological Markers;Biological Sciences;burden of illness;career;caregiver depression;Caregivers;caregiving;Caring;Cessation of life;Clinical;Cognitive;Cognitive Therapy;Collaborations;cost;cytokine;Data;dementia caregiving;Depressed mood;design;Development;Diagnosis;Disease Progression;Dissemination and Implementation;Educational workshop;efficacy testing;Emotional;Enrollment;Equipment and supply inventories;Evidence based intervention;experience;expressive writing;Fatigue;Feedback;Five-Year Plans;Focus Groups;Funding;Future;Grant;Grief reaction;healing;Health;Health Benefit;heart rate variability;Human;improved;Inflammation;Inflammatory;innovation;Internet;Intervention;K-Series Research Career Programs;Literature;loved ones;Mediating;Medical center;Mental Health;Mentors;Mentorship;Morbidity - disease rate;mortality;Observational Study;Participant;physical conditioning;Physiological;primary outcome;Production;programs;Public Health;Publishing;Quality of life;Randomized, Controlled Trials;recruit;reduce symptoms;Research;Research Activity;response;Rice;Risk;Science;Scientist;secondary outcome;Self Care;Self Efficacy;Social Environment;Spouse Caregiver;Spouses;Stress;stress reduction;Symptoms;targeted treatment;Testing;Texas;Therapeutic Intervention;therapy development;Time;Training;Training Activity;Translating;United States National Institutes of Health;Universities;Widow;Widowhood;Writing

PROJECT_TITLE: Writing to Heal: Developing an Internet-Based Cognitive-Behavioral Writing Intervention for Alzheimer’s Disease Spousal Caregivers

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Centrosomes play a crucial role in the successful segregation of chromosomes during spermatogenesis. Mis- regulation of centrosome processes can lead to sperm aneuploidy and infertility. Using mouse mutant model systems, we aim to assess the process of centriole and centrosome biogenesis in order to better understand their roles in the context of spermatogenesis.

PI_NAMEs: SKINNER, MARNIE  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Affect;Age;Aneuploidy;Biogenesis;Biological Models;Cell Cycle;Cell division;Cell Physiology;Cells;Centrioles;Centrosome;chromosome missegregation;Chromosome Segregation;Chromosomes;conditional knockout;Coupled;Couples;Cytoplasmic Organelle;Data;Defect;Diploid Cells;DNA biosynthesis;Ensure;Event;experimental study;Failure;Flagella;follow-up;Gametogenesis;gamma Tubulin;Genetic Materials;Germ Cells;Goals;Haploidy;Immunofluorescence Microscopy;Immunohistochemistry;Immunoprecipitation;in silico;Infertility;Investigation;Knockout Mice;Lead;Link;Literature;Mass Spectrum Analysis;Meiosis;Meiotic Prophase I;Microtubule Polymerization;Microtubule-Organizing Center;Microtubules;Mitosis;Mitotic;Modeling;mouse model;mutant mouse model;novel;Organelles;overexpression;Pathway interactions;Phase Transition;Phosphorylation;Play;PLK1 gene;Process;Process Assessment;Prophase;protein degradation;Protein Dynamics;Proteins;Regulation;Reporting;reproductive;Role;S phase;Sister Chromatid;Site;sperm cell;Spermatocytes;Spermatogenesis;Techniques;Testing;trafficking;Up-Regulation;Western Blotting

PROJECT_TITLE: Regulation of Centrosome Biogenesis During Mammalian Spermatogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-L(20)L]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The RISE national patient registry has broken new ground in connecting rheumatology practices around the country in a large data network, measuring quality, and providing continuous feedback on clinical performance. The proposed study will generate scientific evidence to establish the impact of RISE on clinical outcomes, while at the same time helping us understand the mechanisms of its impact through the in-depth study of registry dashboard use patterns and qualitative studies with stakeholders. Data generated through this research will inform improvements to RISE that maximize its impact on health outcomes for people with rheumatic diseases.

PI_NAMEs: SCHMAJUK, GABRIELA  (contact);YAZDANY, JINOOS

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Address;Affect;American;Area;Back;care delivery;Clinical;clinical care;Clinical Data;clinical practice;Collaborations;college;Country;dashboard;Data;data dashboard;data registry;data warehouse;design;Development;Effectiveness;Eligibility Determination;evidence base;Feedback;Feeds;field study;Foundations;Generations;Goals;Health;health care quality;health disparity;health record;Health Services Research;Health system;human centered design;improved;Incentives;Inflammatory Arthritis;information organization;Infrastructure;innovation;Intervention;Interview;Knowledge;Learning;Link;Measurement;Measures;Medicare;Medicare claim;Methods;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;Online Systems;Outcome;patient registry;patient safety;Patients;Pattern;payment;Performance;Persons;Physicians;practice setting;programs;Provider;Public Health;public health priorities;Qualifying;Qualitative Research;Quality of Care;Registries;Reporting;Research;Resources;Rheumatism;Rheumatoid Arthritis;rheumatologist;Rheumatology;Selection Bias;Series;Structure;study characteristics;System;Techniques;Time;tool;United States;United States Centers for Medicare and Medicaid Services;Update;usability;Variant;Work

PROJECT_TITLE: Impact of Registry Use on Quality and Outcomes in Rheumatology (QORA)

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE (OVERALL) The Center for Molecular Studies in Digestive and Liver Diseases (CMSDLD) supports a diverse community of basic, translational, and human subject researchers focused on digestive and liver disease at the University of Pennsylvania Perelman School of Medicine, the Children’s Hospital of Philadelphia and the Corporal Michael J. Crescenz VA Medical Center. Through its four biomedical research core facilities overseen by an administrative core, CMSDLD fosters multidisciplinary collaborative research amongst the Center’s membership focused on the prevention and treatment of disease. Promotion of advances in research knowledge is enabled by a robust enrichment series with financial support for the development of junior investigators made possible through a Pilot and Feasibility grant program.

PI_NAMEs: WU, GARY D. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Abbreviations;Address;Applications Grants;Area;Award;Back;base;bench to bedside;Big Data Methods;Biology;biomedical data science;Biomedical Research;career;Clinical;cohesion;Collaborations;Communities;Core Facility;Creativeness;Data Science Core;Development;Diet;Digestive System Disorders;Disease;Education;Environment;Environmental Impact;Environmental Risk Factor;Evolution;Faculty;Financial Support;Fostering;Funding;Future;Gastrointestinal tract structure;Gene Modified;Grant;Growth;gut microbiota;Health;Human;human subject;Human Subject Research;innovation;Institution;Intestines;Investigation;Knowledge;Leadership;Left;Liver;Liver diseases;Malignant Neoplasms;Medical center;medical schools;Medicine;member;microbial host;microbiome;Mission;Molecular;molecular imaging;molecular pathology;multidisciplinary;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nutritional Science;Pediatric Hospitals;Pennsylvania;Philadelphia;Play;Positioning Attribute;Prevention;programs;repository;Research;Research Personnel;Research Support;Resources;Schools;Scientist;Series;Services;success;symposium;Technology;United States National Institutes of Health;Universities


PROJECT_TERMS: Administrator;Applied Research;Appointment;Area;Award;base;bench to bedside;Biology;Biomedical Research;career;Charge;Chicago;Collaborations;Communities;Core Facility;Creativeness;Department chair;design;Development;Diet;Digestive System Disorders;Doctor of Philosophy;Engineering;epithelial stem cell;experience;Feedback;Fostering;Gastroenterology;genome sciences;Grant;Hepatology;high dimensionality;Human Subject Research;innovation;Institution;Interdisciplinary Study;interest;Laboratories;Lead;Leadership;Liver;Liver diseases;Medical center;medical schools;Medicine;meetings;member;microbiome;Mission;Molecular;Molecular Biology;Names;National Institute of Diabetes and Digestive and Kidney Diseases;Nutritional;Nutritional Science;Pediatric Hospitals;Pennsylvania;Philadelphia;Positioning Attribute;programs;Regenerative Medicine;Research;Research Personnel;Research Support;Schedule;Schools;senior faculty;Sister;stem cell biology;success;translational genetics;Translational Research;Universities

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Natural Products

ORG_CITY: Columbus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The spread of antimicrobial resistance is global threat to human health that necessitates the urgent development of new antibiotics. In this we utilize genomics accelerate the discovery and characterization of phosphonic acids natural products, compounds with significant potential as future antibiotics. Our research will provide important answers to questions on how Nature makes these compounds and deliver a steady stream of new molecules with properties useful to antibiotic drug development.

PI_NAMEs: JU, KOU-SAN  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Genomics-Accelerated Discovery and Biosynthesis of Phosphonic Acid Natural Products

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Data Science;Digestive Diseases;Genetics;Human Genome;Liver Disease;Microbiome;Precision Medicine

PROJECT_TERMS: Address;Animal Model;base;bench to bedside;Big Data;Big Data Methods;biobank;Bioinformatics;Biological Models;Biological Specimen Banks;biomarker identification;biomedical data science;Biometry;Clinical;Clinical Data;Clinical Research;Collection;Computer Analysis;Core Facility;Data;Data Analyses;Data Science Core;Data Set;Databases;design;Development;Digestive System Disorders;Disease;DNA Sequencing Facility;Electronics;Environmental Risk Factor;Evolution;experimental study;Gene Expression;Generations;Genes;Genomics;Growth;gut microbiome;gut microbiota;host-microbe interactions;Human;Human Biology;Human Microbiome;human subject;Human Subject Research;In Vitro;instrument;interest;Intervention;Leadership;Liver diseases;Mammalian Cell;member;Messenger RNA;metabolome;metabolomics;Microbe;microbial;microbial host;Microbial Taxonomy;microbiome;microbiome research;microbiota;Modality;Modification;Molecular;Monitor;mouse model;Mucosal Immunity;multidimensional data;next generation sequencing;novel marker;Pancreatic Diseases;Pathogenesis;Pennsylvania;Phenotype;Physiology;Play;Population;pre-clinical;precision medicine;prevent;Production;Property;Proteins;repository;Research;Research Project Grants;Research Support;Role;Services;System;Technology;Therapeutic;transcriptomics;Translating;Translational Research;Universities

PROJECT_TITLE: Host-Microbial Analytic and Repository Core (H-MARC)


NIH_SPENDING_CATS: Cancer;Regenerative Medicine;Skin Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Narrative Most melanocytic diseases arise in the skin epidermis (e.g. vitiligo and melanoma), but epidermal melanocytes remain drastically under examined because of the paucity of appropriate tools which specifically target these cells in preclinical mouse models. We have created a novel mouse model termed OCA2-creERT to solely target epidermal MC populations to reveal OCA2+ epidermal melanocytes are long-lived, capable of both self-renewal and differentiation and bear tumor-initiating potential, signifying that they are stem/precursor cells. The goal of this grant is to completely characterize the stemness of OCA2+epidermal melanocytes and begin to understand their molecular regulation with the ultimate goal of establishing new strategies to target epidermal melanocytes to prevent and treat pigmentation disorders including melanoma.

PI_NAMEs: ITO, MAYUMI  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Address;Affect;Behavior;Belief;beta catenin;BRAF gene;Cell Proliferation;Cells;Clinical Research;Collaborations;Data;Disease;Epidermis;Event;Exhibits;Funding;gain of function;Gene Expression;Goals;Grant;Hair;Hair follicle structure;Homeostasis;Human;Hyperpigmentation;In Vitro;in vivo;Inflammatory;irradiation;Ligands;Location;loss of function;Malignant Neoplasms;melanocyte;Melanocytic nevus;Melanoma;melanomagenesis;Modeling;Molecular;mouse model;mutant;Mutation;Natural regeneration;Nevus;novel;Nuclear;Oncogenic;overexpression;Pathway interactions;Phenotype;Physiological;Pigmentation Disorders;Pigmentation physiologic function;Play;Population;pre-clinical;precursor cell;prevent;Process;Proliferating;receptor;regeneration function;regenerative;Regenerative capacity;Regulation;Reporting;response;Role;self-renewal;Signal Pathway;Signal Transduction;Skin;Skin Cancer;Skin Pigmentation;skin wound;Source;stem;stem cell biology;stem cells;stemness;Stimulus;Testing;Tissues;tool;tumor initiation;Ultraviolet B Radiation;Vitiligo;WNT Signaling Pathway;wound

PROJECT_TITLE: The regulation of melanocyte stem cells by Wnt signaling

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

PI_NAMEs: KATZ, JONATHAN P (contact)

PROJECT_TERMS: Biomedical Research;Cells;Charge;Collaborations;Comparative Pathology;Consultations;Core Facility;cost;cost effective;Country;COVID-19 pandemic;Digestive System Disorders;DNA Sequencing Facility;Equipment;experience;Floor;Fluorescence;Fostering;Funding;gastrointestinal;Gastrointestinal tract structure;histological image;Histology;Human Resources;Image;Image Analysis;Immunofluorescence Immunologic;Immunohistochemistry;In Situ Hybridization;Individual;Institution;Laboratories;Leadership;Liver;Liver diseases;Manuals;medical schools;member;Microscope;Microscopy;Modeling;Molecular;molecular imaging;molecular pathology;Needs Assessment;new technology;next generation sequencing;Organ;Organoids;Pancreas;Pancreatic Diseases;Pathologist;pathology imaging;Pennsylvania;Positioning Attribute;Process;Productivity;Program Research Project Grants;programs;Quality Control;Reagent;Reproducibility;Research;Research Personnel;Research Training;Resources;Services;skills;Slide;Specialist;Specimen;square foot;Stains;Surveys;synergism;System;Techniques;Technology;Tissues;Training;transcriptomics;U-Series Cooperative Agreements;Universities;Veterinary Medicine;Veterinary Schools

PROJECT_TITLE: Molecular Pathology and Imaging Core (MPIC)


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research

ORG_CITY: EAST LANSING

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative This project seeks to overcome a widely recognized but also widely ignored challenge that has long plagued the study stuttering: the fact that stuttering behaviors vary greatly from task-to-task, from situation-to-situation, and from time-to-time. We will collect and analyze the largest-ever samples of stuttered speech in real-world situations, so that we can develop more accurate measures of stuttering behavior that can be used in clinical and research settings. Our improved understanding of why stuttering varies and how this variability affects people who stutter will directly support improvements in the assessment and treatment of the disorder and ultimately help to reduce the adverse impact of stuttering for the roughly three million individuals in the United States who live with stuttering.

PI_NAMEs: YARUSS, J. SCOTT  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TITLE: Stuttering in the real world: Quantifying variability to improve measurement reliability and validity

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


PI_NAMEs: EPSTEIN, DOUGLAS J (contact)

PROJECT_TERMS: Applications Grants;blastocyst;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complement;computerized;conditioning;Consultations;cost;cost effective;CRISPR/Cas technology;Cryopreservation;Derivation procedure;design;Development;developmental genetics;Digestive System Disorders;disease model;DNA;Doctor of Philosophy;Electroporation;Embryo;embryo cryopreservation;embryonic stem cell;Ensure;Equipment;Equipment and supply inventories;Etiology;experience;Experimental Models;Fertility;Fertilization in Vitro;Funding;gene function;Gene Modified;Generations;Genes;Genetic;Genome;genome editing;Goals;Grant;Harvest;Herpes zoster disease;Hormonal;improved;Infrastructure;Injections;Institution;Intracytoplasmic Sperm Injections;Joints;Knock-in Mouse;Knock-out;Laboratories;Laboratory Research;Lasers;Liver diseases;Maintenance;male fertility;medical schools;member;Microinjections;Microsurgery;Modeling;Modification;Molecular;mouse genome;mouse model;Mus;novel therapeutic intervention;Oocytes;Pennsylvania;preservation;Procedures;professor;Publications;Reagent;Research;Research Personnel;Resources;RNA;Role;Sampling;Services;Speed;sperm cryopreservation;Technology;Time;Training;Transgenic Mice;Transgenic Organisms;Universities;Wait Time

PROJECT_TITLE: Genetically Modified Mouse Core (GMMC)


NIH_SPENDING_CATS: Clinical Research;Data Science;Digestive Diseases;Liver Disease;Microbiome

PI_NAMEs: LEE, HONGZHE  (contact)

PROJECT_TERMS: Animal Model;Area;bench to bedside;Bioinformatics;Biology;biomedical data science;Biometry;Clinical;Clinical Research;Collaborations;Collection;Complex;Computational Biology;Consultations;Data;Data Collection;data registry;Data Science Core;Databases;design;Development;Digestive System Disorders;Disease;disease natural history;disorder risk;Doctor of Philosophy;Documentation;Education;Electronic Health Record;Environment;Epidemiology;Evolution;experience;Gastrointestinal Diseases;Goals;Government;Health;Health Insurance;Human;human subject;Human Subject Research;improved;insurance claims;Intestines;Link;Liver;Liver diseases;Medicine;member;Metadata;Methods;microbial host;microbiome;microbiome analysis;Molecular;multidimensional data;multiple omics;Onset of illness;Patient Care;patient registry;Pennsylvania;Procedures;professor;Protocols documentation;repository;Research;Research Design;Research Personnel;Research Support;Resources;response;Running;Science;Services;Standardization;Statistical Methods;therapeutic target;Time;tool;Translational Research;Universities;Work

PROJECT_TITLE: Biomedical Data Science Core (BDSC)


ADMINISTERING_IC: HG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: SANTA CRUZ

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative Dockstore aims to become the scientific communities’ publishing platform for computational analyses, enabling their creation, sharing and usage according to FAIR principles. This proposal will extend Dockstore to make it more robust and dependable, to allow it to store new content types, such as programming notebooks, and to build chains of trust between tool creators and users. The proposal also advances training, outreach and partner programs to educate a new generation of users in making and using computational tools for biomedicine.

PI_NAMEs: LORETH, CHRISTINE ;PATEN, BENEDICT  (contact);STEIN, LINCOLN D.

PROGRAM_OFFICER_NAME: WELLINGTON, CHRISTOPHER

PROJECT_TERMS: Address;Adopted;Agreement;Atlases;Authorization documentation;base;Biological;Cells;chain of trust;Cloud Computing;cloud platform;Code;Collaborations;Communities;Complex;computational platform;Computational Science;Computer Analysis;computerized tools;Computing Methodologies;Consensus;data access;Data Set;Development;digital object identifier;Ecosystem;Education and Outreach;Educational workshop;Ensure;Environment;FAIR principles;Feedback;Funding;Generations;Genomics;Goals;Grant;Growth and Development function;Health;Human;improved;Infrastructure;infrastructure development;Institution;Language;laptop;Learning;Life Cycle Stages;Link;Metadata;Methods;Morphologic artifacts;National Human Genome Research Institute;Nature;open source;Operating System;outreach;peer;Peer Review;Persons;Printing;programs;Publications;Publishing;Publishing Peer Reviews;rapid growth;repository;Reproducibility;Reproduction;Resources;Running;Science;Secure;Series;Services;social;software development;Systems Integration;Testing;tool;Training;Trust;U-Series Cooperative Agreements;web app;webinar;Work

PROJECT_TITLE: Dockstore: The Community Platform for Reproducible Biomedical Workflows and Applications

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative  While nearly 40 million women in the United States undergo mammography screening each year, 1 in 8 breast cancers are still missed due to the limitations of human radiologist interpretation even with the use of newer tests like 3D mammography. Recently, multiple promising artificial intelligence technologies for automated mammography interpretation have become commercially available but are unlikely to be widely adopted in clinical practice until they are shown to improve screening outcomes over radiologist interpretation alone. We will evaluate the performance of four leading artificial intelligence technologies for automated 3D mammography interpretation on a diverse national screening cohort and then leverage an established breast cancer simulation model to estimate the long-term benefits, harms, and costs associated with adopting AI tools for 3D mammography interpretation for the U.S. screening population to inform key stakeholders prior to their widespread clinical translation.

PI_NAMEs: LEE, CHRISTOPH I (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: 3-Dimensional;Academy;Address;Adopted;algorithm training;Algorithms;Artificial Intelligence;artificial intelligence algorithm;Biometry;Breast Cancer Detection;Breast Cancer Epidemiology;Breast Cancer Surveillance Consortium;breast imaging;Cancer Detection;cancer diagnosis;Cancer Intervention and Surveillance Modeling Network;Characteristics;Clinical;Clinical effectiveness;clinical practice;clinical translation;Clinical/Radiologic;cohort;comparative;computer aided detection;cost;cost effectiveness;Data;Data Set;deep learning algorithm;deep neural network;Detection;detection platform;Digital Breast Tomosynthesis;Digital Mammography;digital technology;Effectiveness;Ensure;Evaluation;Feedback;follow-up;Funding;Future;Geography;Health Benefit;Health Services Research;Healthcare;Human;Image;improved;improved outcome;Industry;industry partner;Informatics;Infrastructure;Institution;Internal Medicine;International;Knowledge;Label;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Medicine;Modeling;models and simulation;mortality;multilevel analysis;neoplasm registry;novel;Outcome;Patient-Focused Outcomes;Performance;Physicians;Policy Maker;Population;population based;Privatization;prospective;Prospective Studies;radiologist;Reader;Registries;screening;Screening procedure;Target Populations;Technology;Technology Assessment;Testing;Time;tool;Translations;Triage;tumor;United States;United States Food and Drug Administration;Update;Validation;Visual Perception;Woman;Women's Group

PROJECT_TITLE: Population-Based Evaluation of Artificial Intelligence for Mammography Prior to Widespread Clinical Translation


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Liver Disease;Microbiome

PI_NAMEs: WELLS, REBECCA G (contact)

PROJECT_TERMS: Achievement;Applied Research;Award;base;Basic Science;Biometry;Clinical Sciences;Communities;Core Facility;Data;Development;Digestive System Disorders;Engineering;experience;Faculty;Fostering;Funding;Funding Agency;Goals;Grant;Growth;innovation;Investments;Liver diseases;medical schools;Medicine;member;Mentorship;microbiome;microbiome research;Molecular;multidisciplinary;Pediatric Hospitals;Pennsylvania;Philadelphia;preference;programs;Recording of previous events;Regenerative Medicine;Research;Research Personnel;Schools;Scientist;Techniques;Testing;translational medicine;translational therapeutics;United States National Institutes of Health;Universities;Veterinary Medicine;Veterinary Schools

PROJECT_TITLE: Pilot and Feasibility Grant Program


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Although groundbreaking advances have enhanced the effectiveness of cancer treatment, many large epithelial tumors remain uncontrolled at the primary site and/or develop distant disease, which is almost always fatal. Our research could lead to the dramatic improvements required for the treatment of both local and systemic disease and in the overall cures of locally advanced and metastatic cancers. We speculate that activating cytotoxic CD8+ T cells and alleviating host immunosuppression are key to unleashing the full anti-tumor potential of both radiotherapy and radioimmunotherapy.

PI_NAMEs: WEICHSELBAUM, RALPH R (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: adaptive immunity;Address;anti-PD-L1;anti-PD-L1 antibodies;Antigen Presentation;antigen processing;Antigens;antitumor effect;Binding;Binding Proteins;Binding Sites;Bioinformatics;Biology;cancer care;cancer therapy;Cathepsins;Cause of Death;Cell Culture Techniques;Cell Differentiation process;Cell Physiology;Cells;Cellular Immunity;checkpoint inhibition;Clinical;Clinical Trials;Collaborations;Combined Modality Therapy;Complex;cytotoxic CD8 T cells;Data;Dendritic cell activation;Dendritic Cells;Development;Disease;Disseminated Malignant Neoplasm;Distant;Effectiveness;Epithelium;experimental study;Future;Gene Expression;Gene Expression Regulation;Genes;Goals;Immune;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunologics;immunoregulation;Immunosuppression;Immunotherapy;improved;Infiltration;inhibitor;innovation;Irradiated tumor;Knowledge;Localized Disease;Locally Advanced Malignant Neoplasm;loss of function;Malignant Neoplasms;Mediating;Mediation;Messenger RNA;Methods;Methylation;migration;Modification;Molecular;monocyte;Myelogenous;Myeloid Cells;Natural Immunity;Neoplasm Metastasis;novel;novel strategies;Oncology;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;PD-1/PD-L1;Play;Positioning Attribute;posttranscriptional;pre-clinical;Property;prototype;Radiation;Radiation therapy;Radioimmunotherapy;Reader;Regulation;Rejuvenation;Reporting;Research;Research Personnel;response;RNA;RNA methylation;Role;screening;Site;small molecule;Solid Neoplasm;Specificity;Systemic disease;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;Targeted Radiotherapy;Techniques;Testing;Therapeutic;Therapeutic Effect;therapy resistant;Time;transcriptome sequencing;Translations;treatment strategy;tumor;Tumor Immunity;tumor microenvironment

PROJECT_TITLE: Elucidating the Roles of RNA m6A readers Y1 and Y2 in radiation-induced immunity and immunotherapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


PROJECT_TERMS: Achievement;Area;base;Basic Science;Biology;career;career development;Categories;Clinical Sciences;cohesion;Collaborations;Communication;Communities;design;Development;Digestive System Disorders;Disease;Education;Equity;equity, diversity, and inclusion;experience;Faculty;falls;Fostering;Goals;graduate student;Grant;hands on research;innovation;interest;International;Knowledge;Learning;Liver;Liver diseases;Medical Students;member;Mentors;Mentorship;Modeling;Molecular;new technology;Oral;oral communication;Participant;Physiology;Postdoctoral Fellow;posters;professor;Program Development;programs;Research;research and development;Research Personnel;Research Support;role model;Scientific Advances and Accomplishments;Scientist;Series;skill acquisition;skills;symposium;Technology;technology/technique;Training;Training Programs;Training Support;undergraduate student;United States National Institutes of Health;Update;Vocational Education;Writing

PROJECT_TITLE: Enrichment Program


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE This project will use a mixed-methods approach to examine health care providers' responses to the State of Minnesota's novel health insurance design: tiered cost-sharing for primary care “gatekeeper” clinics that are responsible for the patient's total cost of care. Tiered cost-sharing provides consumers with the information and incentives they need to choose efficient health care providers, and rewards efficient providers with greater patient volume.

PI_NAMEs: DOWD, BRYAN EDWIN (contact)

PROGRAM_OFFICER_NAME: KARACA, ZEYNAL

PROJECT_TITLE: Analysis of a Tiered Clinic Cost-sharing Health Insurance Benefit Design

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Cystic Fibrosis;Diabetes;Digestive Diseases;Lung;Nutrition;Pediatric;Prevention;Rare Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: NARRATIVE Diabetes is a major co-morbidity in pancreatic insufficient cystic fibrosis and associated with worse outcomes. While reduced β-cell mass contributes to the insulin deficiency that characterizes cystic fibrosis-related diabetes (CFRD), other modifiable determinants appear operative in the emergence and progression of abnormal glucose tolerance towards diabetes. Identifying 1) the contribution of insulin secretory defects and related modifiable and non-modifiable factors to the emergence and progression of abnormal glucose tolerance and 2) interventions to preserve β-cell function are crucial for delaying and potentially altogether preventing CFRD development.

PI_NAMEs: KELLY, ANDREA BRIDGET (contact);RICKELS, MICHAEL R

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Acute;Adolescence;Adult;Affect;Age;aged;Agonist;Alpha Cell;Arginine;Attention;Beta Cell;Body Composition;Cell Physiology;Childhood;Chronic;Clinical;clinical phenotype;cohort;comorbidity;Cross-Over Studies;Cross-Sectional Studies;Cystic Fibrosis;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Defect;Development;Diabetes Mellitus;diabetes risk;Diet;dietary;Disease;Double-Blind Method;early childhood;Early Diagnosis;Early Intervention;efficacy testing;Evaluation;Exhibits;Exocrine pancreas;Exocrine pancreatic insufficiency;Exposure to;Foundations;Functional disorder;gastric inhibitory polypeptide receptor;Genetic;Genetic Risk;genetic variant;Genotype;glucagon-like peptide 1;Glucose;Glucose Intolerance;glucose tolerance;Glucose tolerance test;Goals;Grant;Guidelines;hazard;high risk;Hormones;Hour;hyperglucagonemia;impaired glucose tolerance;Impairment;improved;incretin hormone;Individual;Inflammation;Infusion procedures;Insulin;Insulin deficiency;Insulin Resistance;insulin secretagogues;insulin secretion;Interruption;Intervention;Intestines;islet;Longitudinal Studies;Lung;Lung Transplantation;mortality;Multicenter Studies;multidisciplinary;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional;Nutritional status;OGTT;Outcome;Participant;Pathogenesis;Patients;Persons;Phase;Placebo Control;Placebos;preservation;Prevalence;prevent;primary outcome;progression risk;pulmonary function;Randomized;recruit;Resistance;Role;screening;Secretory Cell;Testing;Tissues;Translating;Translations;Variant;VX-770;Work;young adult;Youth

PROJECT_TITLE: Evaluation of the entero-insular (incretin) axis in cystic fibrosis-competitive renewal.

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Pediatric

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Eating behavior dimensions, including Food Approach, Food Avoidance, Food-Associated Self-regulation, Food-Associated Affect, and Liking for Sweet, are associated with dietary quality and growth in children and are therefore important to public health. The proposed study has the potential for high impact by establishing the predictive value of infant eating behavior traits and their moderation by maternal feeding practices for future health outcomes. The findings have a high likelihood of providing new intervention targets.

PI_NAMEs: LUMENG, JULIE C (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 5 year old;6 year old;Address;Adult;Affect;Age;Area;Attention;Behavior;behavior measurement;Behavioral;behavioral phenotyping;Body mass index;Characteristics;Child;Child Development;Childhood;cohort;Data Collection;Desire for food;Development;Diet;dietary;Dimensions;early childhood;Eating Behavior;Exposure to;feeding;follow-up;Food;food avoidance;Funding;Future;Growth;Health;high body mass index;Individual;infancy;Infant;infant temperament;Informal Social Control;Intervention;intervention effect;Literature;Measures;Modeling;Nature;novel;obesity risk;observational cohort study;Outcome;Parents;Phenotype;Predictive Value;Predisposition;prospective;Prospective Studies;Protocols documentation;Public Health;Publishing;Reporting;Resources;response;Stimulus;Structure;sucking;Temperament;Testing;therapy development;Time;trait;United Kingdom;Weight Gain;Work

PROJECT_TITLE: The Development of Eating Behavior in Infancy: Associations with Behavior, Diet, and Growth to Age 6 years


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Gastroparesis is a chronic gastrointestinal motility disorder with no cure, which causes significant burden to patients and the healthcare system. The proposed research aims to identify the cellular mechanisms underlying this disease, by focusing our analysis on immune cells residing in the human stomach. Knowledge from this research is likely to result in the identification of novel cellular pathways that can be targeted therapeutically to treat, reduce symptoms, and cure gastroparesis.

PI_NAMEs: IDOYAGA, JULIANA  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Affect;Biological Assay;Calcitonin Gene-Related Peptide;Cells;Chronic;chronic abdominal pain;Clinical Research;cytokine;Cytometry;Data;Dendritic Cells;Diabetic mouse;dimensional analysis;Dimensions;Disease;Enteric Nervous System;Environment;Functional disorder;Gastric Emptying;Gastrointestinal Motility;Gastroparesis;Goals;Health Care Costs;Healthcare Systems;high dimensionality;Human;Immune;immune function;Immune response;immunoregulation;Incidence;Infiltration;Inflammatory;Interstitial Cell of Cajal;Intestines;Knowledge;Macrophage;Microscopy;Modeling;monocyte;Mononuclear;Motility;motility disorder;mouse model;Mucous Membrane;Mus;Muscle;National Institute of Diabetes and Digestive and Kidney Diseases;Nausea and Vomiting;Neurons;Neuropeptides;novel;novel therapeutic intervention;Organ;Pathway interactions;Patients;Peptide Signal Sequences;Peptides;Phagocytes;Phenotype;Population;Production;Proxy;rational design;reduce symptoms;Research;Resolution;Role;Sampling;Stomach;stomach motility;targeted treatment;Testing;Therapeutic;Thick;Time;Tissues

PROJECT_TITLE: From stomach tissue to cellular mechanisms: unraveling the role of mononuclear phagocytes in the pathophysiology of gastroparesis


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Pediatric;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: MONTREAL

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: MCGILL UNIVERSITY

ORG_STATE: QC

ORG_ZIPCODE: H3A 0G4

PHR: My research concerns the question of why drug use in adolescence is a strong predictor of lifetime abuse. To answer this, I study the effects of stimulant drugs on the molecular and structural changes that are ongoing in the brain during adolescence. This work is carried out in both males and females investigating the effects of therapeutic-like doses and excessive drug exposure.

PI_NAMEs: FLORES, CECILIA  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Age;Amphetamine Sulfate;Amphetamines;Anatomy;Axon;axon growth;behavior test;Behavioral;Behavioral inhibition;Brain;Brain region;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;Cognitive;cognitive control;Cre lox recombination system;CRISPR-mediated transcriptional activation;Cues;Data;design;Development;Dextroamphetamine;diagnostic value;dimorphism;Dopamine;dopaminergic neuron;Dose;Down-Regulation;Drug abuse;Drug Exposure;drug of abuse;Drug usage;Drug user;early adolescence;Event;experimental study;Exposure to;Female;frontal lobe;gain of function;Genes;Goals;Growth;Impaired cognition;Impairment;in vivo;Lead;Learning;Life;loss of function;male;Male Adolescents;Measurement;Measures;Medial;Mediating;Methods;MicroRNAs;Modification;Molecular;Morphology;Motivation;Mus;nerve supply;Neuroanatomy;neurochemistry;Neurons;neurotransmission;novel;NTN1 gene;Nucleus Accumbens;overexpression;Pharmaceutical Preparations;Plasma;Play;postnatal;postsynaptic;Predisposition;Prefrontal Cortex;Process;Psychopathology;Publishing;receptor;receptor expression;Recreation;Recreational Drugs;Research;resilience;Rewards;Risk;Role;Route;sex;Sex Bias;Sex Differences;Signal Transduction;Source;Stimulant;Structure;Synapses;Testing;Therapeutic;Therapeutic Effect;Time;Translating;Vertebral column;Viral;vulnerable adolescent;Work

PROJECT_TITLE: Amphetamine in adolescence disrupts frontal cortex development

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE This proposal is of great public health and clinical importance because understanding the role of aging in cancer risk and outcomes in cancer survivors may inform on novel strategies for risk-stratified cancer screening and surveillance. An accurate blood-based measurement of biological aging in cancer will provide a tool that will help facilitate the development of anti-aging therapies before and after cancer diagnosis.p 1

PI_NAMEs: PRIZMENT, ANNA  (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Acceleration;Adult;Age;age acceleration;age-related disease;Aging;aging clocks;Agreement;anti aging;anti aging drug;Area;Atherosclerosis Risk in Communities;biological age;Biological Aging;Biological Assay;Biological Markers;biomarker identification;Black race;Blood;Body mass index;Cancer Detection;cancer diagnosis;Cancer Etiology;cancer risk;cancer site;cancer survival;Cancer Survivor;cancer therapy;cancer type;Cause of Death;Cessation of life;Characteristics;Chronic;Chronology;Clinical;clinically significant;Cognitive;cohort;Consensus;cost efficient;Data;Deceleration;Development;Diagnosis;Education;epigenetic aging;epigenetic clock;Epigenetic Process;Exclusion;experience;frailty;Future;Immune response;improved;indexing;Individual;Inflammation;Intervention;Knowledge;Life Style;Malignant Neoplasms;Measurement;Measures;men;Metformin;Morbidity - disease rate;mortality;Multi-Ethnic Study of Atherosclerosis;novel;novel strategies;Obesity associated cancer;Outcome;Participant;Performance;Persons;Pharmaceutical Preparations;Physiological;Plasma Proteins;population based;Premature Mortality;prospective;Proteins;Proteomics;Public Health;Publishing;Race;Recording of previous events;Research;Research Personnel;Residual Cancers;Residual state;Risk;Risk Factors;risk stratification;Role;Screening for cancer;senolytics;sex;sex risk;Site;Smoking;Supervision;Survival Rate;Survivors;Testing;Time;tool;Training;transcriptomics;Validation;Visit;Woman;Work

PROJECT_TITLE: Proteomic aging in adults before and after cancer diagnosis

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE The goal of this project is to establish routinely successful prolonged normothermic ex vivo heart perfusion (NEVHP) leading to organ banks. We have demonstrated routinely successful perfusion of hearts for 24-72 hours using plasma exchange with a paracorporeal animal, then fresh plasma alone, then continuous hemofiltration in ovine and porcine models. With this proposal, we expect to determine the factors responsible for prolonged NEVHP, demonstrate routine 3-day perfusion. In addition, the NEVHP protocols and systems will be tested to resuscitate hearts after prolonged periods of cold ischemia and hearts from DCD.This is a critical step to translate the animal models into clinical practice.

PI_NAMEs: ROJAS-PENA, ALVARO  (contact)

PROGRAM_OFFICER_NAME: FENTON, KATHLEEN NELLE

PROJECT_TERMS: Animal Model;Animals;Blood;Cessation of life;clinical practice;Cross Circulation;Cryopreservation;Development;Devices;Disease;Distant;Dose;Evaluation;ex vivo perfusion;experimental study;Family suidae;Filtration;gene therapy;Goals;Heart;Heart failure;heart function;Heart Transplantation;Hemofiltration;Hour;Human;Ice;immunoregulation;implantation;Infusion procedures;injury recovery;insight;Ischemia;Liver;Lung;Organ;Organ Preservation;Organ Transplantation;Perfusion;Pharmacology;Physiology;Plasma;Plasma Exchange;porcine model;prevent;Procedures;Process;Proteomics;Protocols documentation;Reperfusion Injury;Research;Resuscitation;Role;Sheep;sheep model;Site;System;Testing;Time;Translating;Transplantation;Transportation;Warm Ischemia;Weight

PROJECT_TITLE: Prolonged Normothermic Ex vivo Heart Perfusion (NEVHP)

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

PHR: PROJECT NARRATIVE Heart and vascular disease is a leading cause of disability and death in the United States. The Johns Hopkins Cardiology Post-doctoral Training Program, now in its 44th consecutive year, provides broad multi-disciplinary training spanning from basic science up through to population/outcomes research. Our goal is to train the next generation of academic cardiovascular research leaders to continue the work of tackling these important and common diseases.

PI_NAMEs: KASS, DAVID ALAN;POST, WENDY S (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Cardiomyopathies;Functional disorder

PROJECT_TITLE: Pathophysiology of Myocardial Disease

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ORG_CITY: CLEVELAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE The CWRU Short-Term Heart Lung and Blood Research Opportunities program will provide key support for underrepresented minority and disadvantaged undergraduate and medical students in research education in order to expose students to biomedical challenges in cardiovascular, pulmonary, hematologic and sleep research. This experience, coupled with additional activities will strengthen their confidence as researchers, bolster their competiveness for subsequent graduate and medical programs, and encourage students to continue academic research.

PI_NAMEs: MONTANO, MONICA  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Achievement;angiogenesis;Area;Arrhythmia;Asthma;Atherosclerosis;Awareness;Bacterial Pneumonia;Basic Science;Biology;Biomedical Research;Blood;Blood Vessels;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;career;career development;Cell surface;Cellular biology;Childhood;Clinical;Clinical Research;Communities;Coupled;Cystic Fibrosis;Databases;Dedications;Disadvantaged;Education;education research;Endothelial Cells;Environment;epidemiology study;Evaluation;experience;Exposure to;Faculty;falls;follow-up;Foundations;Funding;Goals;graduate student;Health Disparities Research;health disparity;Health Professional;Heart;Heart failure;Hematological Disease;Hematology;Host Defense;Hypoxia;Immunology;improved;Institution;instrument;interest;Laboratories;Laboratory Research;Lead;lectures;Leukocytes;Lung;Lung Diseases;matriculation;Measures;Medical;medical schools;Medical Students;Medicine;meetings;Mentors;Mesenchymal Stem Cells;National Heart, Lung, and Blood Institute;Natural Immunity;Outcome;Outcome Measure;peer;Population;Population Research;posters;Preparation;Process;programs;Publications;Records;Recruitment Activity;Request for Proposals;Research;Research Activity;Research Design;Research Personnel;Research Proposals;Research Training;Residencies;Respiration Disorders;respiratory;Respiratory Muscles;Rewards;role model;Science;skills;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Social Interaction;stem cell biology;Structure;Students;summer research;symposium;System;Technical Expertise;Training;Training Programs;Translational Research;Transplantation;Tuberculosis;undergraduate student;Underrepresented Minority;Underrepresented Students;Universities;Work

PROJECT_TITLE: Short term heart, lung, blood research opportunities


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Cancer;Neurosciences;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Chemotherapy-induced cognitive impairment (CICI) is a major, severe long-lasting neurotoxic side effect of widely used chemotherapeutics that significantly impacts the quality of life of cancer survivors. The mechanisms are largely unknown and there are no FDA approved medicines. We present the first evidence that activation of the sphingosine 1-phosphate receptor subtype 1 (S1PR1) is germane to CICI and identify a novel therapeutic approach with S1PR1 antagonists already approved for other indications (fingolimod, ozanimod).

PI_NAMEs: FARR, SUSAN A;SALVEMINI, DANIELA  (contact)

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: Address;Affect;antagonist;antitumor effect;Anxiety;Attention;Attenuated;Biological Availability;Brain;cancer therapy;cell growth;Central Nervous System;chemobrain;chemotherapy;Cisplatin;Clinical Research;Cognition;cognitive function;cognitive testing;cytokine;Data;Development;Disease;Dose;drug repurposing;edg-1 Protein;Enzymes;FDA approved;Female;G-Protein-Coupled Receptors;genetic approach;Hippocampus;IL18 gene;Impaired cognition;Inflammasome;Inflammation;Inflammatory;insight;interdisciplinary approach;Interleukin-1 beta;Intervention;Learning;Letters;Ligands;Link;long-term sequelae;male;marenostrin;Measurement;Measures;Mediating;Medical;Medicine;Memory;Mental Depression;Metabolism;mitochondrial dysfunction;Molecular;molecular targeted therapies;Motor Activity;Multiple Sclerosis;Mus;Neoplasm Metastasis;neoplastic cell;Neuroglia;neuroinflammation;neurotoxic;neurotoxicity;new therapeutic target;nitration;Nitrogen;novel;novel therapeutic intervention;Oral Administration;Paclitaxel;Patients;Peroxonitrite;Pharmaceutical Preparations;pharmacologic;Pharmacology;Platinum;Prefrontal Cortex;prevent;Prevention;Preventive;Process;Production;Proteins;Quality of life;quality of life for cancer survivors;Reactive Oxygen Species;receptor;Reporting;response;Role;Safety;side effect;Signal Transduction;SOD2 gene;Sphingolipids;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Stress;Superoxides;Synapses;targeted treatment;taxane;Testing;Therapeutic;Therapeutic Intervention;Time;time use;TLR4 gene;Translational Research;Treatment Efficacy;tumor

PROJECT_TITLE: Fingolimod and Ozanimod for the treatment and prevention of chemobrain


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Rare Diseases;Women's Health Research

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Triple Negative Breast Cancer (TNBC) is an aggressive metastatic breast cancer subtype with limited targeted therapies and poor prognosis. The molecular underpinnings promoting metastasis continue to be elucidated and include phenotypic and metabolic changes that support changing demands during the metastatic cascade. I aim to evaluate how the epithelial-to-mesenchymal transition of tumor cells creates metabolic vulnerabilities that can be targeted therapeutically, with a focus on cholesterol uptake mechanisms.

PI_NAMEs: O'NEILL, KATHLEEN  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 3-Dimensional;Automobile Driving;Autophagocytosis;Basement membrane;Breast Cancer Cell;breast cancer diagnosis;breast cancer progression;Breast Epithelial Cells;cancer cell;Cancer Prognosis;cancer subtypes;Cell Death;cell growth;Cell Line;cell motility;Cell Survival;Cells;Chemoresistance;Cholesterol;Cholesterol Homeostasis;Clinical;Data;Dependence;Diffuse;Disseminated Malignant Neoplasm;Distant;Endocytic Vesicle;epithelial to mesenchymal transition;Epithelium;Estrogen receptor positive;Evaluation;experience;experimental study;extracellular;Extracellular Matrix;Extracellular Matrix Degradation;FRAP1 gene;Gene Expression;Genes;Grant;In Vitro;in vivo Model;Indolent;insight;interest;Invaded;knock-down;Laboratories;LDL Cholesterol Lipoproteins;Lead;Literature;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Lysosomes;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuscripts;mechanical signal;Mechanics;mechanotransduction;Mediating;Mentors;Mesenchymal;Metabolic;Metabolism;metabolomics;Metastatic breast cancer;MicroRNAs;migration;Molecular;Molecular Target;Motility;Neimann-Pick's Disease Type C;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Newly Diagnosed;novel;particle;Pathway Analysis;Patients;Phase;Phenotype;Physiology;Postdoctoral Fellow;Preparation;Process;Prognosis;protein metabolism;Regulation;Research;Research Project Grants;Resistance;Resources;response;restoration;Role;Sampling;Site;Small Interfering RNA;small molecule inhibitor;Source;standard care;Stromal Cells;Supporting Cell;targeted treatment;Technical Expertise;Technology;Testing;Therapeutic;therapeutic development;therapeutic target;Tissues;tool;Training;triple-negative invasive breast carcinoma;tumor;tumor metabolism;tumor microenvironment;tumor progression;uptake;Very low density lipoprotein;VLDL receptor;Work

PROJECT_TITLE: Lysosomal metabolism as a targetable driver of pancreatic cancer


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: KANSAS CITY

ORG_NAME: KANSAS CITY UNIVERSITY

PHR: Project Narrative Quick detection of emotion has been widely studied with adults but little is known about how this perceptual ability develops. The proposed study will document the development of emotion detection; specifically, the time course of emotion detection, potential preferential processing of threat-related emotions, how low-level visual features influence detection, how autonomic nervous system activity is differentially modulated by emotional content, and whether speed of processing on emotion detection tasks influences later social development. This research has implications for typically and atypically developing populations, in that emotion detection is severely impaired in individuals with autism spectrum disorder and has cascading effects, such as deficits in online perception of fluctuating emotional states, perceiving social cues, efficient mimicry of emotional expressions, and basic empathy processes.

PI_NAMEs: ZIEBER, NICOLE  (contact)

PROJECT_TERMS: Address;Adult;Age;Age Months;Anger;Area;Arousal;Attention;autism spectrum disorder;Autonomic nervous system;Award;Awareness;Behavioral;behavioral response;Categories;collaborative environment;Cross-Sectional Studies;Cues;Data;Detection;Development;Diameter;Discrimination;Doctor of Philosophy;Emotional;emotional stimulus;Emotions;Empathy;experience;Experimental Psychology;experimental study;Eye;Face;Face Processing;Facial Expression;follow up assessment;Fright;Goals;Happiness;Health;Impairment;indexing;Individual Differences;individuals with autism spectrum disorder;infancy;Infant;Infant Development;information processing;Interdisciplinary Study;interest;Knowledge;life span;Literature;Longitudinal Studies;Masks;Measures;Mediating;Methods;mimicry;Modeling;Negative Valence;Nervous System Physiology;Outcome;Pattern;Perception;Phase;Population;Positioning Attribute;Positive Valence;Postdoctoral Fellow;preference;Process;processing speed;Property;Protocols documentation;Psychometrics;Publications;Pupil;rapid detection;Research;Research Personnel;response;Saccades;Sampling;showing emotion;Side;skills;Smiling;social;Social Development;Social Functioning;Speed;Statistical Methods;Stimulus;tenure track;Testing;Time;Tonic Pupil;Training;Universities;virtual;Visit;Visual;visual tracking

PROJECT_TITLE: Young Infants' Detection of Emotion


NIH_SPENDING_CATS: Genetics;Muscular Dystrophy;Orphan Drug;Rare Diseases

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Mutations in protein chaperones are associated with degenerative diseases including muscular dystrophy. Consistent with this, mutations in DNAJB6 cause Limb Girdle Muscular Dystrophy 1D. This proposal will explore DNAJB6 dysfunction using yeast, in vitro, and animal models. These studies will define the molecular pathogenesis and identify novel therapeutic interventions.

PI_NAMEs: TRUE-KROB, HEATHER L (contact);WEIHL, CONRAD C

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Affect;Amyloid;Animal Model;autosome;Biological Models;Cell model;Cells;Client;conformer;Data;Defect;Degenerative Disorder;Desmin;Development;Disease;disease phenotype;Functional disorder;gene correction;Gene Modified;Goals;Grant;Guanine Nucleotide Exchange Factors;Heat shock proteins;heat-shock proteins 40;Heat-Shock Proteins 70;Human;human induced pluripotent stem cells;In Vitro;in vivo;Inherited;inhibitor;Intermediate Filaments;Knock-in Mouse;Limb-Girdle Muscular Dystrophies;Mammalian Cell;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;mouse model;Mus;Muscle;Muscle Cells;Muscle Fibers;Muscular Dystrophies;mutant;Mutation;Myofibrils;Myopathy;novel therapeutic intervention;novel therapeutics;Nucleotides;Pathogenesis;Pathogenicity;Pathology;Patients;Phenotype;prion-like;Prions;Process;protein aggregation;protein TDP-43;Proteins;proteostasis;Regional Disease;Reporting;RNA-Binding Proteins;Role;Site;Skeletal Muscle;small molecule;success;sup35;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;tool;Toxic effect;Transgenic Mice;Work;yeast genetics;Yeasts

PROJECT_TITLE: Chaperone Dysfunction in Myopathy: Connecting Yeast Genetics with Mouse Models

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Mycobacterium avium is an environmental bacterium that is capable of infecting humans and causing serious disease, requiring months to years of antibiotic treatment to cure. This proposal aims to use novel genetic tools to identify the bacterial genes that allow some strains of M. avium to establish chronic infection, and the pathways that allow M. avium to tolerate prolonged antibiotic exposure once infection is established. In doing so, this work will provide fundamental insights into how environmental bacteria evolve into pathogens, and lay a foundation for the development of improved therapies for this and other chronic bacterial infections.

PI_NAMEs: CAREY, ALLISON  (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Acute;Address;Antibiotic Therapy;antibiotic tolerance;Antibiotics;antimicrobial;Bacteria;bacterial fitness;Bacterial Genes;Bacterial Genome;Bacterial Infections;Bar Codes;Biodiversity;Bioinformatics;Biological;Catalogs;Characteristics;Chronic;chronic infection;Clinical;clinically relevant;Communicable Diseases;comparative genomics;Creativeness;Data;design;Development;Diagnostic;Disease;disease phenotype;drug efficacy;Drug Exposure;emerging antimicrobial resistance;emerging pathogen;Environment;Experimental Genetics;experimental study;fitness;Foundations;Genes;Genetic;Genetic Determinism;Genetic Variation;genome wide association study;Genomic approach;Genomics;Genotype;Heterogeneity;Human;Impairment;improved;In Vitro;in vivo;Incidence;Infection;insight;interest;Link;Maps;Measurement;Methods;Microbe;microbial;Molecular;Morbidity - disease rate;mouse model;Mus;Mutation;mycobacterial;Mycobacterium avium;Mycobacterium tuberculosis;novel;novel strategies;Opportunistic Infections;Organism;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;phenotypic data;Postdoctoral Fellow;Predisposition;programs;public health intervention;Research;response;skills;Techniques;Technology;Testing;Therapeutic;therapeutically effective;tool;trait;Treatment outcome;treatment response;Vaccination;vaccine efficacy;Vaccines;Virulence;Work

PROJECT_TITLE: Parallel phenotyping to dissect genetic determinants of bacterial strain diversity


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Pediatric;Rare Diseases;Tuberculosis

PHR: Project Narrative While >90% of the ~10 million TB cases that occur annually are curable, treatment is dependent on inadequate diagnostics that are currently based exclusively on detection of Mycobacterium tuberculosis (Mtb) in patient sputum, despite the limitations of sputum as a diagnostic sample, as it is almost impossible to obtain from patients with paucibacillary TB, such as people living with HIV and children, and is not diagnostic for patients with extrapulmonary TB. Our long-term goal is to transform TB diagnosis with a blood test that accurately distinguishes patients with TB disease from latent TB infection and other pulmonary disorders regardless of co- infection with HIV. The objective of this study is to demonstrate the analytical and clinical performance of a novel assay for rapid diagnosis and treatment monitoring of TB that exploits the precise molecular affinity of CRISPR and promiscuous nuclease activity of Cas12a to detect ultra-low concentrations of Mtb cell free DNA (cfDNA) circulating in peripheral blood of patients with TB disease.

PI_NAMEs: GARFEIN, RICHARD S;RODWELL, TIMOTHY CHARLES (contact)

PROGRAM_OFFICER_NAME: JONES, FATIMA D

PROJECT_TERMS: accurate diagnosis;Address;Adult;Affinity;Aftercare;Arkansas;Binding;biobank;Biological Assay;Biological Markers;Blood;Blood specimen;Blood Tests;California;cell free DNA;Cessation of life;Child;Childhood;Clinical;Clinical Research;Clinical Sensitivity;Clustered Regularly Interspaced Short Palindromic Repeats;co-infection;cohort;Collaborations;Communicable Diseases;cost;COVID-19;cross reactivity;Cryopreservation;Detection;detection assay;detection limit;Diagnosis;Diagnostic;diagnostic criteria;Diagnostic Sensitivity;Diagnostic Specificity;Disease;DNA;DNA Binding;Drug resistance in tuberculosis;Extinction;Fluorescence;Goals;Growth;HIV;Immunocompromised Host;innovation;isothermal amplification;Laboratories;Lateral;lateral flow assay;Lung Diseases;Mexico;Microscopy;Molecular;molecular diagnostics;Monitor;mortality;Mycobacterium tuberculosis;non-tuberculosis mycobacteria;Nonlinear Dynamics;novel;nuclease;Pakistan;Paper;Patient-Focused Outcomes;Patients;Pediatrics;Performance;peripheral blood;Persons;Pharmaceutical Preparations;Pilot Projects;point-of-care diagnostics;Predisposition;Process;prospective;Proteins;rapid detection;rapid diagnosis;rapid test;Reader;Reference Standards;Reporter;Reporting;Research;Resource-limited setting;Risk;Sampling;Sensitivity and Specificity;Signal Transduction;South Africa;Specificity;Sputum;technology platform;Testing;transmission process;Triage;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;tuberculosis treatment;United States National Institutes of Health;Universities

PROJECT_TITLE: Rapid Detection of TB from Blood using Cell-Free DNA and CRISPR

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Irregular sleep schedules represent a common source of chronic sleep and circadian disruption in the contemporary world, but its impact on cardiometabolic disease remains poorly understood. This application combines traditional epidemiology with omics techniques and digital phenotyping to characterize the relationships between irregular sleep schedules and cardiometabolic disease risk. This research will advance our understanding of the mechanisms linking irregular sleep to cardiometabolic disease, and has potential to lead to new strategies for targeted prevention of cardiometabolic disease and reduce health disparities.

PI_NAMEs: REDLINE, SUSAN S. (contact)

PROGRAM_OFFICER_NAME: KUNZ, JOHN FREDERIC

PROJECT_TERMS: Accelerometer;Accounting;actigraphy;Age;Arginine;Attenuated;Awareness;biobank;Biological;Biological Process;Blood;Blood Pressure;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cardiovascular Physiology;child bearing;Chronic;circadian;Circadian Dysregulation;Circadian Rhythms;cohort;Collection;Data;Data Collection;Development;Diabetes Mellitus;digital phenotyping;disorder prevention;disorder risk;Disparity;Dose;Eating;Epidemiology;epidemiology study;ethnic minority;Ethnic Origin;Ethnic Population;European;Exhibits;experience;Exposure to;fitbit;Fostering;Genes;Genetic;Genetic Predisposition to Disease;Genetic Risk;Genomics;handheld mobile device;Health;Health Promotion;heart rate variability;Human;Hypertension;improved;Incidence;Individual;innovation;Intervention;Link;linoleates;low socioeconomic status;Measures;Mediating;Metabolic;metabolic profile;Metabolic syndrome;metabolomics;modifiable risk;Multi-Ethnic Study of Atherosclerosis;Nobel Prize;novel;Nurses;Nurses' Health Study;Obesity;obesity risk;Occupational;Omega-3 Fatty Acids;Outcome;Ownership;Participant;Pathogenicity;Pathway interactions;Pattern;Plasma;Population;population based;Prevalence;Prevention;prospective;Public Health;Race;racial minority;racial population;Recommendation;Reduce health disparities;Reproducibility;Research;Research Design;response;Risk;Risk Factors;Role;Rotation;Sample Size;Sampling;Schedule;sex;shift work;Sleep;Sleep Disorders;Sleep disturbances;Sleeplessness;sociodemographic factors;sociodemographics;Source;Subgroup;Symptoms;Techniques;trait;Translating;translational progress;Tyrosine;Variant;Woman;Work

PROJECT_TITLE: The role of irregular sleep schedules as a ubiquitous marker of chronic circadian disruption in cardiometabolic disease development

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Learning about how cells work and what happens when they don’t work properly teaches us how to keep us healthy and fight diseases. This project will develop new technologies to enhance our ability to study individual cells and their collective working. Therefore, this contributes to fundamental understanding and their applications to improved diagnosis and treatment.

PI_NAMEs: YUN, SEOK-HYUN ANDY (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Antibodies;Area;Award;Bar Codes;Behavior;Biological Sciences;biological systems;biomaterial compatibility;cell behavior;Cell Physiology;Cells;Cellular Phone;Color;Communication;Data;Data Set;Development;Devices;Diagnosis;Diagnostic;dimensional analysis;Dimensions;Disease;DNA;Educational process of instructing;Environment;experimental study;fighting;fluorophore;Frequencies;Goals;Healthcare;Image;improved;In Situ;in vivo;in vivo imaging;Individual;innovation;insight;instrument;Isotopes;large scale data;Lasers;Learning;Life;Light;Location;meter;Methodology;Molecular;Movement;nanoparticle;new technology;next generation;novel;nucleobase;Oligonucleotides;Optics;particle;Persons;Physiology;Reader;Research;Series;Signal Transduction;single cell analysis;single cell sequencing;success;System;Techniques;Technology;Telephone;Therapeutic;Time;Tissues;tool;United States National Institutes of Health;Validation;validation studies;wireless;Work

PROJECT_TITLE: Laser particles for multi-dimensional single-cell analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Real-time spectroscopic photoacoustic/ultrasound (PAUS) scanner with simultaneous fluence and motion compensation to guide and validate interventions: system development and preclinical testing Narrative Real-time ultrasound (US) is commonly used to guide interventional procedures, but for injections of therapeutic agents such as ethanol, the drug itself cannot be directly visualized. Photoacoustics (PA), combining pulsed light delivery to the body with US detection of light absorbing structures within the body, has been proposed to bring a molecular dimension to US to help view molecular substances such as drugs, but its clinical translation has been greatly limited by both fundamental issues related to tissue motion and wavelength-dependent light intensity variations within the body and practical issues related to the size, speed, and expense of the laser systems typically used for imaging. Here we present a completely new approach integrating PA and US (PAUS) imaging to directly address both fundamental and practical issues limiting clinical translation, and will test it by developing and evaluating a clinical real-time PAUS system as a robust molecular guidance tool for interventional procedures.

PI_NAMEs: O'DONNELL, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Ablation;absorption;Address;Algorithms;Anatomy;Animal Model;Animals;Area;Blood;Blood capillaries;Blood Vessels;cancer recurrence;Canis familiaris;Characteristics;Clinical;clinical application;clinical translation;Clinical Trials;Coagulative necrosis;Color;Compensation;Contrast Media;Coupling;Detection;Devices;Dimensions;drug distribution;efficacy validation;Ethanol;experimental study;External Beam Radiation Therapy;Fiber;Fiber Optics;flexibility;Goals;high risk;histological studies;Human;human subject;Image;Image Enhancement;image guided;imaging capabilities;imaging probe;improved;in vivo Model;industry partner;Injection of therapeutic agent;Injections;Intervention;Lasers;Light;light intensity;Machine Learning;Malignant neoplasm of thyroid;Malignant Neoplasms;Measurement;Methods;Microbubbles;Modality;Modeling;Molecular;molecular decomposition;Motion;Mus;Needles;Neoplasm Metastasis;Nodule;novel strategies;Operative Surgical Procedures;Optics;Papillary thyroid carcinoma;Patients;Performance;Persons;Pharmaceutical Preparations;photoacoustic imaging;Physiologic pulse;Pilot Projects;Positioning Attribute;Preclinical Testing;Procedures;Prognosis;Protocols documentation;Pump;Radiofrequency Interstitial Ablation;reconstruction;Recurrence;Reporting;Research;Scanning;signal processing;skills;soft tissue;spectroscopic imaging;Spectrum Analysis;Speed;Structure;surgical risk;System;Systems Development;Testing;Thyroid Gland;thyroid neoplasm;Time;Tissues;tool;tumor;Ultrasonography;ultrasound;Universities;Variant;Visualization;Washington;Work

PROJECT_TITLE: Real-time spectroscopic photoacoustic/ultrasound (PAUS) scanner withsimultaneous fluence and motion compensation to guide and validateinterventions: system development and preclinical testing.


NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Hearing loss is largely irreversible because in most cases it involves the loss of cochlear hair cells, which in mammals are for the most part not generated past embryogenesis. As OHCs are much more vulnerable than IHCs, their loss due to age, noise or ototoxic drugs is the main cause of hearing loss, and hence the regeneration of OHCs will be most often needed to restore hearing. Our discovery of the central roles played by transcription factors INSM1, BCL11b and BCL11a in OHC development provides unique and novel means for elucidating how OHCs are generated and aligned, a knowledge that will guide and assist future therapeutic attempts via regeneration.

PI_NAMEs: GARCIA-ANOVEROS, JAIME  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: adeno-associated viral vector;Age;age related;Agonist;Amplifiers;Anatomy;antagonist;ATAC-seq;Binding Sites;Brain;Candidate Disease Gene;Cell Differentiation process;Cessation of life;Chromatin;chromatin modification;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;Cochlea;critical period;deafness;Defect;Development;differential expression;Embryo;Embryonic Development;Endowment;Enhancers;Ensure;epigenome;epigenomics;Funding;Future;Gene Expression;Gene Modified;Genes;Genetic;Genetic Transcription;Genomics;Grant;Hair Cells;Hearing;hearing impairment;hearing restoration;Inner Hair Cells;insulinoma associated 1;Knowledge;Lateral;Ligands;Mammals;Medial;Molecular;Morphogenesis;morphogens;Mus;mutant;Natural regeneration;neural;Neurons;Noise;novel;Organ of Corti;ototoxicity;Outer Hair Cells;paralogous gene;Pattern;Pharmaceutical Preparations;Phenotype;Physiological;Play;Positioning Attribute;Predisposition;presynaptic;prevent;promoter;Property;Proteins;receptor;Regulatory Element;Research;Role;Signal Pathway;Signal Transduction;sound;sound frequency discrimination;Specific qualifier value;Techniques;Testing;Therapeutic;transcription factor;transcriptome sequencing;transcriptomics;transdifferentiation;transmission process;Zinc Fingers

PROJECT_TITLE: Outer and Inner Hair Cell Development


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Drug Abuse (NIDA only);Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Recovery Support Services;Substance Misuse;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_DEPT: FAMILY MEDICINE

PHR: Project Narrative – Bupropion for the Prevention of Postpartum Smoking Relapse Postpartum smoking relapse affects the health of mothers and their children. Previous work suggests that bupropion may help prevent postpartum smoking relapse by targeting several relapse related risk factors prevalent in women during the postpartum period (e.g., smoking related symptomatology, weight gain, depressive symptoms). If our hypotheses are confirmed, the results from this work may be disseminated into clinical practice and will significantly impact the rate of postpartum smoking relapse, a major public health concern.

PI_NAMEs: ALLEN, SHARON S (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Abstinence;Address;Adherence;Affect;Age;arm;associated symptom;behavior influence;Behavior Therapy;Behavioral;Biological;Bupropion;Child;Childbirth;cigarette craving;cigarette smoke;cigarette smoking;clinical application;clinical practice;Cotinine;Counseling;Data Collection;depressive symptoms;Double-Blind Method;Dysthymic Disorder;Enrollment;environmental tobacco smoke exposure;Expectancy;experience;Fatigue;General Population;Gonadal Steroid Hormones;Gravidity;Health;Health behavior;health of the mother;High Pressure Liquid Chromatography;Hormones;Infant;Intervention;Learning;Literature;Major Depressive Disorder;maternal cigarette smoking;Mediator;medication compliance;Mental Depression;Methods;modifiable risk;Mothers;novel;Outcome;Outcome Measure;Participant;Pharmacotherapy;Placebos;Population;population health;Postpartum Period;Postpartum Women;Predictive Factor;Pregnancy;pregnant;Pregnant Women;Prevalence;prevent;Prevention;Prevention strategy;primary outcome;Procedures;Productivity;prolonged abstinence;Psychosocial Factor;Public Health;Questionnaires;Race;Randomized;randomized placebo-controlled clinical trial;Recording of previous events;Relapse;relapse prevention;relapse risk;Reporting;Reproducibility;Research Personnel;Risk;Risk Factors;Risk Reduction;Role;sample collection;Sampling;Science;secondary outcome;skills;Smoke;Smoking;smoking abstinence;Smoking Behavior;smoking cessation;smoking during pregnancy;smoking relapse;smoking relapse prevention;Smoking treatment;Stress;symptomatology;Time;Tobacco;tobacco exposure;Urine;Vulnerable Populations;Weight;Weight Gain;Woman;Women's prevalence;Women's study;Work

PROJECT_TITLE: Bupropion for the prevention of postpartum smoking relapse

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: Watertown

ORG_NAME: ALDATU BIOSCIENCES, INC.

PHR: HIV drug resistance (HIVDR) genotyping to determine the cause of antiretroviral therapy failure has long been established to improves patient outcomes and reduce HIV transmission, yet the persistent urgent and unmet need for resistance genotyping in low- and middle-income countries has not been met, thus prohibiting the appropriate allocation of subsequent HIV treatment options. This Commercialization Readiness Pilot (CRP) program submission will commercialize the results of our Phase II SBIR where we leveraged the unique capabilities of PANDAA, our qPCR-enabling technology, to successfully develop the first diagnostic for simultaneous focused HIVDR genotyping of six resistance-conferring positions in the protease gene in addition to the K65R and M184VI DRMs. We will establish the regulatory and quality frameworks necessary to manufacture the associated product, a validated HIVDR that significantly reduces test complexity, time burden and costs without sacrificing accuracy, which can radically improve clinical decision-making in low- and middle-income countries.

PI_NAMEs: MACLEOD, IAIN JAMES (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: Acceleration;Adherence;Adoption;Adult;Affect;African;antiretroviral therapy;Award;Binding Sites;Biological Assay;Botswana;Certification;Childhood;Clinical;clinical decision-making;Clinical Research;commercialization;commercialization readiness;Computer software;Contracts;cost;Country;COVID-19 diagnostic;COVID-19 test;COVID-19 testing;Data Analyses;data management;data quality;Dedications;design;Development;Diagnostic;Diagnostic tests;Dideoxy Chain Termination DNA Sequencing;Disease Progression;Documentation;Drug resistance;Early identification;Ensure;Evaluation;experience;Failure;Feedback;Funding;Future;genetic variant;genomic variation;Genomics;Genotype;Health;Healthcare Systems;HIV;HIV drug resistance;Hospitals;implementation study;Improve Access;improved;in-vitro diagnostics;innovation;Institution;International;Ivory Coast;Logistics;low and middle-income countries;Management Information Systems;manufacture;manufacturing process;Marketing;Mediating;Mediation;Medical Device;meetings;New England;Nigeria;Notification;Outcome;pathogen;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Phase;platform-independent;Positioning Attribute;premature;Preparation;prevent;Process;Production;programs;prospective;Protease Inhibitor;Qualifying;Quality Control;Regimen;Reporting;Reproducibility;Research;Resistance;resistance mutation;Resource-limited setting;Resources;Sales;Sampling;Senegal;Side;Site;Small Business Innovation Research Grant;software development;South Africa;System;Technology;Testing;Time;Training;Translating;transmission process;Treatment Failure;Uganda;Validation;Work

PROJECT_TITLE: Commercialization of PANDAA qDx for rapid drug resistance genotyping of protease inhibitor ART failures in resource-limited settings.


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Depression;Genetics;Human Genome;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: NARRATIVE We propose to investigate biological mechanisms behind the association between exposure to maternal psychological stress during the prenatal period and having increased risk for negative psychological outcomes in young children. Our long-term goals are to advance knowledge pertaining to early detection and prevention of these negative effects in young children. Through this proposal, we also aim to build research capacity and collaboration between South Africa and the U.S. to foster scientific discovery.

PI_NAMEs: KLENGEL, TORSTEN ;KOEN , NASTASSJA   ;RESSLER, KERRY J. (contact);STEIN, DAN JOSEPH

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Adult;Affect;Age;Amygdaloid structure;Animal Model;Anxiety;Area;Autopsy;behavior prediction;Behavioral;Biological;Biological Process;Birth;Blood;Brain;Cells;Child;Child Development;Code;cohort;Cohort Studies;Collaborations;Collection;Communities;comorbidity;Country;Data;Data Analyses;Data Collection;Depressed mood;Development;DICER1 gene;differential expression;Early Diagnosis;Emotional;Environment;Environmental Exposure;Epigenetic Process;epigenetic regulation;Exposure to;Fostering;Foundations;Future;Gene Expression Regulation;Generations;Genes;Genetic Transcription;Germ Lines;Glucocorticoid Receptor;Goals;Grant;growth arrest specific transcript 5;Heritability;high risk;Hospitals;Human;in utero;Income;Infant;Infant Development;infant outcome;Infrastructure;Inherited;Institution;interest;Knowledge;late life;Life;low and middle-income countries;maternal stress;Measures;Mediating;Mediator;medical schools;Mental Depression;Messenger RNA;Modeling;Molecular;Mothers;mRNA Expression;Mus;Newborn Infant;novel;Nucleus Accumbens;obstetric outcomes;offspring;Outcome;Parents;Pathway interactions;Pharmaceutical Preparations;Phenotype;Play;Post-Traumatic Stress Disorders;postnatal;posttranscriptional;Pregnancy Outcome;prenatal;prenatal exposure;prenatal stress;prevent;Prevention;Process;prospective;Proteins;psychological outcomes;Psychological Stress;psychosocial;Publications;receptor sensitivity;Regulation;Regulatory Pathway;Research;Resources;Risk;Risk Factors;RNA;Role;Site Visit;South Africa;Stress;stress related disorder;stressor;Suicide;Time;Tissue-Specific Gene Expression;Training;transcriptome sequencing;transgenerational epigenetic inheritance;transmission process;Trauma;trauma exposure;Universities;Untranslated RNA;Work

PROJECT_TITLE: Understanding the transgenerational epigenetic effect of maternal psychosocial trauma exposure on infants via lncRNA-sequencing


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Obesity;Prevention;Uterine Cancer;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Prevention of endometrial cancer in obese women is the ultimate goal of this proposal and this is only achievable if we understand the mechanisms associated with obesity driven endometrial cancer. We will investigate how fat cells influence the epigenome of the endometrial epithelial cells that alter the protective mechanisms of progesterone receptor, thereby increase the risk of developing endometrial cancer.

PI_NAMEs: KIM, JI-YONG JULIE (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: 3-Dimensional;Adipocytes;Adipose tissue;Affect;Benign;Biological Models;bisulfite sequencing;carcinogenesis;Cell Count;Cells;ChIP-seq;Coculture Techniques;deep sequencing;Development;Diagnosis;Disease;DNA Methylation;Endometrial;Endometrial adenocarcinoma;endometrial cancer prevention;Endometrial Carcinoma;Endometrial Neoplasms;endometrial organoid;Endometrium;Environment;Epigenetic Process;epigenome;Epithelial Cells;Estrogens;Fostering;FOXO1A gene;Gene Expression;Genes;genome-wide analysis;Genomics;Goals;Growth;high risk;high risk population;Histones;Hormones;Human;In Vitro;in vitro Model;Incidence;inhibitor;innovative technologies;insight;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Menstrual cycle;Metformin;microfluidic technology;Microfluidics;Modernization;Molecular;obese person;Obesity;Organ;Organoids;Pathway interactions;Patients;permissiveness;Phenotype;Premenopause;prevent;Process;Progesterone;Progesterone Receptors;protective effect;Proto-Oncogene Proteins c-akt;Public Health;receptor;release factor;Research;Resistance;response;Risk;Risk Factors;Role;Sample Size;Signal Transduction;single-cell RNA sequencing;spheroids;Stromal Cells;System;Technology;Testing;theories;Time;Tissues;transcriptome;tumor;tumorigenesis;tumorigenic;whole genome;Woman;Work

PROJECT_TITLE: Understanding Progesterone Receptor action in Obesity for Endometrial Cancer Prevention


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Pulmonary Hypertension

ORG_CITY: PHILADELPHIA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Right ventricular failure (RVF) is a strong predictor of death for which there are no proven therapies and limited prior work investigating molecular mechanisms of RVF. This career development proposal will allow the candidate, a physician-scientist with a career objective to transition to an independent investigator of RVF biology, to examine a novel RVF-specific target that he identified by characterizing the human RVF gene expression signature. In this proposal, he will use complementary in vitro cardiomyocyte and in vivo RV gain and loss of function models to determine the mechanistic role of ROR2 in RVF pathogenesis, which could provide insight for novel RVF therapeutic targets.

PI_NAMEs: EDWARDS, JONATHAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Actins;Acute;adeno-associated virus 9 delivery;Advisory Committees;alpha Actinin;American;animal model development;Animals;Apoptosis;Biology;Calpain;cancer cell;Cardiac Myocytes;Cardiovascular system;career;career development;Cell Surface Receptors;Cellular biology;Cessation of life;Clinical;Clinical Management;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;Complementary DNA;Complex;Critical Thinking;Cytoskeletal Proteins;Cytoskeleton;Data;Development;Development Plans;differential expression;Doctor of Philosophy;Echocardiography;Educational workshop;Eligibility Determination;Environment;Epidemiology;extracellular;F-Actin;Faculty;Failure;fetal;FLNA gene;Flow Cytometry;Fostering;Foundations;Funding;gain of function;Gene Expression Profile;Genes;Goals;Guide RNA;Health;Heart;Heart failure;Heart Transplantation;hemodynamics;Histology;Hospitals;Human;Human Rights;In Vitro;in vivo;in vivo Model;insight;Institution;knock-down;Knowledge;Laboratories;Leadership;Left;Ligands;loss of function;LoxP-flanked allele;Mediating;member;Mentors;Mentorship;Metabolism;model development;Modeling;Molecular;Molecular Biology;mortality;mortality risk;mouse model;Mus;Muscle;Muscle Cells;Myocardial;Neonatal;Neurons;novel;Oryctolagus cuniculus;overexpression;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;pediatric cardiologist;Pediatric Cardiomyopathy;pediatric patients;Pediatric Research;Pennsylvania;Peptide Hydrolases;Phenotype;Physicians;Physiology;Postdoctoral Fellow;pressure;Proteolysis;public health relevance;Pulmonary artery structure;Rattus;receptor;Recombinants;Regulation;Research;research and development;Research Personnel;Research Training;right ventricular failure;Role;Sampling;Scientist;skills;small hairpin RNA;Structure;Technical Expertise;Testing;therapeutic target;Training;Training Programs;Transgenic Animals;Transgenic Organisms;Translational Research;Treatment Failure;treatment response;Universities;Up-Regulation;Ventricular;Western Blotting;WNT Signaling Pathway;WNT5A gene;Work

PROJECT_TITLE: Defining the Role of ROR2 in Right Ventricular Failure Pathogenesis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ORG_CITY: DURHAM

ORG_NAME: AFFINERGY, LLC

ORG_STATE: NC

PHR: PROJECT NARRATIVE Hepcidin is the peptide hormone responsible for regulating circulating iron concentrations, making it clear target for diagnosis and monitoring of multiple hematological conditions. Next generation therapeutics capable of modulating serum hepcidin levels are under advanced clinical evaluation, and will likely require companion diagnostics to assess patient responsiveness and personalize dose ranges. Unfortunately, hepcidin has very low immunogenicity, making it extremely challenging to develop antibodies or immunoassays against the hormone. Using phage display biopanning and a proprietary sandwich assay format, Affinergy has developed a novel hepcidin-25 serological assay which will meet this urgently unmet need, impacting patients with a range of conditions including hereditary hemochromatosis and -thalassemia.

PI_NAMEs: DARBY, MARTYN  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Acute;Amino Acids;Anemia;Anemia due to Chronic Disorder;Antibodies;Antisense Oligonucleotides;Bacteriophages;beta-Galactosidase;Binding;Biological Assay;Blood;Calibration;Carrier Proteins;Cations;Chromatography;Chronic Kidney Failure;Clinical;Clinical Trials;commercialization;companion diagnostics;Competence;Complex;cross reactivity;Data;Detection;detection limit;detection method;Development;Diagnosis;Diagnostic tests;Dietary Iron;digital;Disease;Dose;drug development;Equilibrium;Equus caballus;FDA approved;Funding;Goals;Guidelines;Hematology;Hematopoietic;Hemochromatosis;hepcidin;Hereditary hemochromatosis;Hormones;Immunoassay;immunogenicity;improved;Individual;Inherited;innovative technologies;instrument;instrumentation;Iron;iron absorption;iron deficiency;Iron deficiency anemia;iron metabolism;Iron Metabolism Disorders;Iron Overload;Isotopes;Label;Laboratories;Lead;Libraries;Life;Link;manufacture;manufacturing scale-up;Marketing;Mass Spectrum Analysis;Measures;metal transporting protein 1;Methods;Monitor;nanomolar;new therapeutic target;novel;novel diagnostics;novel therapeutics;overexpression;patient response;Patients;peptide hormone;Peptides;Performance;Peroxidases;personalized care;Phage Display;Pharmaceutical Preparations;Phase;Plasma;Preparation;prevent;Production;programs;protein aminoacid sequence;Protein Isoforms;Radish;Reagent;Renal Carcinoma;Reporting;Reproducibility;research clinical testing;response;Sampling;Serodiagnoses;Serology test;Serum;Small Business Innovation Research Grant;Small Interfering RNA;small molecule;Specificity;stability testing;Streptavidin;Structure;success;Testing;Thalassemia;Therapeutic;time of flight mass spectrometry;tool;toxicant;uptake;Validation;Viola

PROJECT_TITLE: A novel peptide assay for hepcidin clinical monitoring


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Multiple Sclerosis;Neurodegenerative;Neurosciences;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_CITY: MILWAUKEE

ORG_NAME: MARQUETTE UNIVERSITY

ORG_STATE: WI

PHR: Project Narrative The proposed research will evaluate the individual and combined effects of high-intensity exercise and postural perturbations during treadmill training in people with multiple sclerosis. The effects of high-intensity treadmill training with postural perturbations on clinical and laboratory-based locomotor and balance outcomes, as well as changes in community mobility and participation will be demonstrated. This project meets a significant unmet need in the development of rehabilitation approaches in people with MS and has the potential for substantial public health impact.

PI_NAMEs: HORNBY, THOMAS GEORGE;SCHMIT, BRIAN D (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Balance training;Cardiopulmonary;Clinic;Clinical;Clinical Trials;clinically significant;Communities;community setting;design;Development;early phase clinical trial;Elements;Environment;Equilibrium;Exercise;exercise intensity;exercise training;experience;Exposure to;falls;Gait;gait rehabilitation;Gait speed;Goals;Impairment;improved;improved mobility;Incidence;Individual;Intervention;kinematics;Laboratories;locomotor control;Locomotor training;Measures;Mobility decline;Multi-Institutional Clinical Trial;Multiple Sclerosis;multiple sclerosis patient;Musculoskeletal Equilibrium;Nervous System Disorder;neuromuscular;novel;Outcome;Outcome Measure;Participant;Patients;Perception;Persons;Phase;Physical activity;Physiological;Pilot Projects;Posture;primary outcome;Public Health;Quality of life;Rehabilitation therapy;Research;Research Personnel;response;Secondary to;Techniques;Testing;Training;Translating;treadmill;treadmill training;Walking

PROJECT_TITLE: High-Intensity, dynamic-stability gait training in people with multiple sclerosis

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention

ORG_CITY: LAS CRUCES

ORG_DEPT: BIOLOGY

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: The proposed project is relevant to public health because understanding the threats that global climate change poses on the pathogenicity of soil fungi will allow us to better plan for potential outbreaks of fungal infectious diseases, develop contingency plans, and potential treatments. Therefore, this proposal is relevant to NIH’s mission of seeking fundamental knowledge of living systems with the ultimate goal of protecting health and reducing illness.

PI_NAMEs: ROMERO OLIVARES, ADRIANA  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Address;Agglutinins;bioinformatics tool;Blastomycosis;Body Temperature;Candidiasis;Chronic;climate change;Communicable Diseases;Communities;comparison control;copper oxidase;Coupled;desert fever;Disease;Disease Outbreaks;Droughts;Ecosystem;emerging pathogen;Ensure;environmental change;Environmental Impact;environmental stressor;experimental study;Exposure to;functional group;fungus;Future;Gene Expression Profile;Generations;Genes;Genetic;Genetic Transcription;glucan synthase;Goals;Health;Health protection;Heat shock proteins;High-Throughput Nucleotide Sequencing;Individual;innovation;insight;Investments;Knowledge;Life Cycle Stages;Measures;Metalloproteins;Methods;Microbiological Techniques;Microbiology;Mission;Mitotic;Modeling;Mucormycosis;Organism;outbreak concern;outbreak prediction;Outcome;pathogen;pathogenic fungus;Pathogenicity;Pattern;Phenotype;Physiological;Policy Maker;Process;programs;Proliferating;Public Health;Race;Research;Resources;response;Risk;RNA Helicase;Societies;Soil;Stress;stress tolerance;Temperature;Testing;Trehalose;Tube;United States National Institutes of Health;Up-Regulation;virulence gene;vulnerable community;Work

PROJECT_TITLE: Assessing the relationship between fungal pathogenicity and climate change and the risk of emergent pathogens in a changing climate