ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Disability Research;Social Determinants of Health

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE MSTEM scientists are not representative of race, ethnicity, gender, disability or socioeconomic status demographics in the general population. In order to increase underrepresented and disadvantaged researchers in aging and to fully understand the complexities of aging among the growing minority population in the US, the proposed program, Investigators from Novices, a Transdisciplinary Research Education Program to Increase Diversity (INTREPID) in aging research, will provide MSTEM-students an environment that promotes student affinity toward older adults, opportunities for research experiences, and support for successful undergraduate completion, and pursuit of a graduate research degree. Having underrepresented and disadvantaged researchers in aging will have the potential to increase understanding of the relationship between health disparities and aging, and the development of interventions to improve the health of all older adults.

PI_NAMEs: CONNER, NORMA  (contact);HUANG, HELEN J

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Active Learning;Address;Admission activity;Adult;Affective;Affinity;African American;Aging;aging and technology;Asian;Attitude;Biological Sciences;Black race;career;Cognitive;cohort;college;Communities;computer science;culturally appropriate intervention;Data;demographics;Development;disability;Disabled Persons;Disadvantaged;disadvantaged background;disadvantaged student;Discipline;Discipline of Nursing;Disease;Disparity;Disparity population;Education;education research;Educational Curriculum;Educational workshop;Elderly;Engineering;Ensure;Environment;ethnic disparity;Ethnic Origin;Ethnic Population;Event;experience;Faculty;faculty mentor;Florida;Foundations;Funding;Gender;General Population;Goals;Graduate Education;Grant;hands on research;Health;Health Disparities Research;health disparity;higher education;Hispanic;Hispanic-serving Institution;Hospitals;Hour;human old age (65+);improved;Individual;insight;Institution;Intervention;Knowledge;Learning;Life Cycle Stages;life span;mathematical sciences;Measures;Medicine;member;Mentors;Minority Groups;minority investigator;Modeling;Morbidity - disease rate;mortality;Narrative Medicine;Not Hispanic or Latino;older adult;Outcome Measure;Participant;patient engagement;Persons;Physical therapy;Population;Process;programs;Psychology;Publications;Race;racial disparity;racial population;recruit;rehabilitation science;Research;Research Personnel;research study;Research Training;scaffold;Scholars Program;Science;science, technology, engineering, mathematics, and medicine;Scientist;Shapes;skills;social integration;Social Work;Socialization;Socioeconomic Status;Speed;STEM field;STEM program;STEM student;Student Persistence;Students;success;summer institute;supportive environment;Testing;theories;therapy development;Time;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Woman

PROJECT_TITLE: Investigators from Novices, a Transdisciplinary Research Education Program to Increase Diversity (INTREPID) in Aging Research


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: BERKELEY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative: Here, we seek to test a core mechanistic hypothesis: The impact of beta-amyloid (Aβ) burden on anxiety is orchestrated through Aβ-related impairment of NREM slow-wave sleep, which in turn, amplifies next-day anxiety through impaired mPFC-amygdala emotional brain regulation. If supportive, these studies would (i) advance our basic understanding of how Alzheimer’s disease-related pathology mechanistically impacts the core neuropsychiatric symptom of anxiety through impairment of NREM sleep, and (ii) establish sleep improvement as a novel modifiable therapeutic intervention target that may de- escalate anxiety linked with the Alzheimer’s disease state, and potentially the rate of longitudinal disease/cognitive decline.

PI_NAMEs: WALKER, MATTHEW P (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: abeta accumulation;Address;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Amygdaloid structure;Amyloid;Amyloid beta-Protein;Anti-Anxiety Agents;Anxiety;anxiety symptoms;Behavior;Behavioral;beta amyloid pathology;Brain;brain dysfunction;Clinical;Cognition;Cognitive;cohort;Data;depressive symptoms;Detection;Development;Disease;Electroencephalography;Elements;emotion regulation;Emotional;follow-up;Functional Magnetic Resonance Imaging;functional MRI scan;Generations;Impaired cognition;Impairment;improvement on sleep;Individual;Life;Link;longitudinal design;Measures;Mediation;Mental Depression;Methods;Modality;Modeling;Moods;National Institute of Mental Health;Negative Valence;neural;neuromechanism;neuropathology;neuropsychiatric symptom;non rapid eye movement;novel;older adult;Participant;Pathology;Positron-Emission Tomography;Preparation;prevent;prospective;Publishing;Regulation;Research Domain Criteria;Severities;Sleep;Sleep Deprivation;Sleep disturbances;Slow-Wave Sleep;Speed;Testing;Therapeutic Intervention;young adult;β-amyloid burden

PROJECT_TITLE: Sleep Impairment: A Mechanism Explaining Neuropsychiatric Symptoms in Alzheimer's

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Spontaneous network activity in embryonic neural circuits is maintained through changes in homeostatic plasticity mechanisms. We are studying these mechanisms as they drive changes that will define the maturation of network excitability and will help us understand the hyperexcitability that is associated with several neurodevelopmental disorders.

PI_NAMEs: WENNER, PETER A (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TITLE: The role of intrinsic cellular excitability in homeostatic plasticity of developing circuits

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The peptide neurotensin is known to play a critical role in modulating the activity of dopamine neurons in the brain, affecting reward-related behaviors and the response to drugs of abuse. However, much remains unknown regarding the specific circuits that release neurotensin and the interaction between neurotensin and other co-released neurotransmitters. This proposal utilizes advanced genetic and imaging techniques to address these questions, aiming to further our understanding of how neurotensin circuits govern motivated behavior.

PI_NAMEs: SODEN, MARTA E (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Accounting;Action Potentials;addiction;Address;Adult;Affect;Anatomy;Behavior;Behavioral;behavioral response;behavioral sensitization;Binding;Biological Models;Brain;Brain region;calcium indicator;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;CRISPR/Cas technology;Cues;Dependence;Dissection;Dopamine;dopamine system;dopaminergic neuron;drug of abuse;Electrophysiology (science);experimental study;feeding;Fiber;Fluorescence;Fluorescent in Situ Hybridization;Food;gamma-Aminobutyric Acid;Genes;genetic manipulation;Genetic Techniques;Glutamates;Hypothalamic structure;Imaging Techniques;In Situ Hybridization;in vivo;in vivo imaging;Individual;Label;Lateral;Learning;Link;Location;Locomotion;Maps;Measures;Medial;Methods;Modality;Monitor;motivated behavior;Motivation;Mus;Mutagenesis;nerve supply;Neurons;Neuropeptides;Neurotensin;Neurotensin Receptors;neurotransmitter release;Neurotransmitters;Nucleus Accumbens;optogenetics;Peptides;Performance;Pharmaceutical Preparations;Pharmacology Study;Photometry;Physiological;Play;Preoptic Areas;Property;Psychological reinforcement;receptor;Reporting;response;retrograde transport;reward processing;Rewards;Role;Second Messenger Systems;Signal Transduction;Slice;Source;Stimulus;Study models;Synapses;System;Techniques;tool;Tracer;Ventral Tegmental Area;vesicular GABA transporter;vesicular glutamate transporter 2;Viral;Virus

PROJECT_TITLE: Differential modulation of dopamine neurons by distinct neurotensin inputs

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Retinitis pigmentosa is an inherited blinding condition that affects an estimated 1 out of 3,500 Americans and currently does not have any curative treatments. The proposed project aims to investigate the mechanisms causing deterioration of the retina (the light-sensitive part of the eye) in patients afflicted by retinitis pigmentosa. The project will also use mice with retinitis pigmentosa to evaluate new strategies for treating this condition.

PI_NAMEs: ALEKSEEV, OLEG  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Affect;American;Assessment tool;Binding;Binding Sites;Blindness;Catalytic Domain;cellular pathology;Cellular Stress;cellular targeting;ciliopathy;Clinical Trials;curative treatments;Data;Deterioration;Development;disease-causing mutation;dosage;Drug Evaluation;Drug Kinetics;Drug Targeting;Electroretinography;Enhancers;Equilibrium;Etiology;Exhibits;experimental study;Eye;Frequencies;gene therapy;Genes;genetic approach;genetic manipulation;Goals;Histologic;Histology;Human;Impairment;Inherited;Intervention;Investigation;Knock-out;Knockout Mice;Light;Modeling;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Mutation;Neurodegenerative Disorders;overexpression;Pathogenesis;Pathology;Patients;Persons;Pharmacodynamics;pharmacologic;photoreceptor degeneration;Process;Productivity;Protein Biosynthesis;protein degradation;Proteins;proteostasis;response;restoration;Retina;Retinal Degeneration;Retinal Diseases;retinal toxicity;Retinitis Pigmentosa;Rhodopsin;Role;Route;Site;small molecule;Stress;stress reduction;System;Therapeutic;Therapeutic Effect;Therapeutic Intervention;tool;Ubiquitin

PROJECT_TITLE: Role of Proteasome Overload in Pathogenesis of Retinitis Pigmentosa


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: NARRATIVE This project aims to address the major problem of biologics delivery for cancer treatment and management by developing a new class of biomimetic nanocarrier, RNP. Compared to prior arts, this delivery technology avoids the cationic charges yet still achieving all the desired functionalities for combinatorial siRNA therapy.

PI_NAMEs: GAO, XIAOHU  (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: A/J Mouse;Address;Antisense Oligonucleotide Therapy;attenuation;base;Binding;biodegradable polymer;Biological Products;Biology;biomaterial compatibility;Biomimetics;cancer therapy;Cell Line;cell type;Cells;Charge;Chemicals;Chimera organism;Chronic;Clinical;clinical translation;Clinical Trials;combinatorial;Complex;Conflict (Psychology);cytotoxicity;delivery vehicle;design;Development;Double-Stranded RNA Binding Domain;efficacy evaluation;Elements;Endosomes;Engineering;Ensure;Epitopes;Evaluation;Evolution;FDA approved;flexibility;Genetic;Goals;Grant;Human;Immobilization;Immune system;immunogenicity;improved;In Vitro;in vivo;Inflammation;Inflammatory;innovation;interest;knock-down;Ligands;Link;Lipids;Liposomes;Liver;Mediating;Medicine;Messenger RNA;Methods;Modification;Molecular;monomer;Mus;nanocarrier;nanoparticle;Nanotechnology;Nature;Organoids;Pathologic;Patients;Peptides;Performance;Pharmaceutical Preparations;Phase;phase III trial;Physical condensation;Polymers;Production;Property;Proteins;Ribonucleoproteins;RNA;RNA delivery;RNA Interference;RNA-Binding Proteins;Safety;self assembly;Serology;Shapes;Site;Small Interfering RNA;small molecule;sortase;Surface;targeted delivery;Technology;technology platform;Therapeutic Agents;therapeutic RNA;tool;Toxic effect;translational potential;Treatment Efficacy;tumor eradication;tumor progression;virtual

PROJECT_TITLE: Targeted RNA delivery using ribonucleoprotein


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Hepatitis;Liver Disease;Microbiome;Nutrition;Prevention;Substance Misuse

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PI_NAMEs: BARVE, SHIRISH S (contact)

PROJECT_TERMS: Address;Alcohol consumption;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Animal Model;Bacteria;Biological Markers;Butyrates;Clinical;Clinical Data;Clinical Research;cohort;Collection;Data;Development;dietary;Dietary Intervention;Dietary Supplementation;Disease Marker;dysbiosis;efficacy evaluation;efficacy testing;Enteral;evidence base;Exhibits;Fatty Liver;fecal transplantation;Funding;gut bacteria;gut dysbiosis;gut-liver axis;Hepatic;Histone Deacetylase Inhibitor;Human;human model;human study;IL17 gene;Immune;immune activation;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;Injury;innovation;insight;Intervention;Knowledge;Liver;liver development;Liver diseases;liver inflammation;liver injury;Mediating;microbial;microbial community;mouse model;Mus;Neutrophil Infiltration;nutrition;Nutritional;organ injury;Pathogenesis;Pathogenicity;Patient Recruitments;Patients;Play;preclinical study;prevent;Preventive;Probiotics;problem drinker;Prodrugs;Production;programs;Resources;Role;Severity of illness;systemic inflammatory response;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Transplantation;treatment strategy;tributyrin;United States National Institutes of Health

PROJECT_TITLE: Pathogenic Role of Loss of Butyrate Producing Bacteria in Immune Dysregulation and Development of Alcoholic Liver Disease (ALD)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: 8. PROJECT NARRATIVE Interactions between proteins and nucleic acids give rise to self-assembly and phase separation that directly impact gene regulation, cell-cell signaling, and amyloid aggregation. This research will develop new technologies to visualize the motions, organization, and interactions of these biomolecules at the molecular level. These technologies will be an invaluable tool in the study of the mechanisms of Alzheimer’s disease and amyotrophic lateral sclerosis (ALS).

PI_NAMEs: LEW, MATTHEW D (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Algorithm Design;Alzheimer's Disease;Amyloid;Amyloidosis;Amyotrophic Lateral Sclerosis;Architecture;Binding;Biocompatible Materials;Biophysical Process;Cells;Complex;cytotoxicity;Data;deep learning;Development;Diagnostic;Dimensions;driving force;Evolution;Fluorescence;fluorophore;Funding;Gene Expression Regulation;Goals;Heterogeneity;Image;imaging capabilities;imaging system;In Vitro;Individual;insight;intercellular communication;Lighting;Maps;Measurement;Measures;Methods;Microscope;Modeling;Molecular;molecular dynamics;molecular imaging;Motion;nanoscale;Nanoscopy;network architecture;new technology;novel;Nucleic Acids;Peptides;Phase;Photons;Physical condensation;Positioning Attribute;Process;programs;protein aminoacid sequence;Proteins;Pupil;quantum;recruit;Research;Resolution;Scientist;self assembly;single molecule;spatiotemporal;Speed;Structure;Techniques;Technology;Therapeutic;Time;tool;Visualization

PROJECT_TITLE: Six-Dimensional Single-Molecule Nanoscopy for Elucidating the Dynamic Organization of Biomolecules


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: Project Narrative  Telomeres are ends of linear chromosomes and essential for long-term cell proliferation and survival. Telomerase, the enzyme that elongates telomeres, plays an important role in cancers and aging-related diseases. This grant application is proposed to determine the mechanisms of telomerase regulation during development and in somatic cells.

PI_NAMEs: ZHU, JIYUE  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: age related;Aging;aging related disease;Alleles;Applications Grants;Bacterial Artificial Chromosomes;cancer cell;Cell Differentiation process;Cell Proliferation;Cell Survival;Chromatin;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Compensation;Degenerative Disorder;Development;Distal;DNA;Elements;Elongation by Telomerase;Engineering;Enhancers;Enzymes;Funding;Gene Activation;Genes;Genetic Transcription;Genomics;Goals;HDAC4 gene;Homeostasis;Human;human disease;improved;in vivo;innovation;Introns;Laboratories;Malignant Neoplasms;Mediating;Methods;Molecular;mouse model;Mus;Play;Pluripotent Stem Cells;Predisposition;recombinase;Regulation;Regulatory Element;Reporter;Reporting;Repression;RNA-Directed DNA Polymerase;Role;Site;Somatic Cell;Specific qualifier value;Techniques;Telomerase;telomere;TERT gene;tool;transcription factor;Transcriptional Regulation

PROJECT_TITLE: Regulation of human telomerase

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Complementary and Integrative Health;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Intellectual and Developmental Disabilities (IDD);Natural Products;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Substance Misuse

PI_NAMEs: CHEN, SHAO-YU  (contact)

PROJECT_TERMS: Address;Alcohol abuse;alcohol consumption during pregnancy;alcohol exposure;Alcohols;Behavioral;Binding;Broccoli - dietary;Cell Physiology;cell type;Congenital Abnormality;craniofacial development;Defect;Development;Disease;DNA;Edible Plants;Elements;Embryo;embryonic alcohol exposure;Embryonic Development;Enhancers;Epigenetic Process;Ethanol;Event;exosome;Fetal Alcohol Spectrum Disorder;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Human;Impairment;innovation;insight;Learning Disabilities;maternal alcohol use;Mediating;migration;nanoparticle;Neural Crest Cell;Neuronal Dysfunction;novel therapeutic intervention;nutrition;organ injury;Pathogenesis;Prevalence;prevent;Prevention;Prevention approach;Prevention strategy;programs;Psyche structure;Regulation;Role;Site;Sulforaphane;teratogenesis;Testing;Therapeutic;transcription factor;Variant;Work;Zebrafish

PROJECT_TITLE: Enhancer-mediated transcriptional dysregulation in neural crest cells and ethanol-induced teratogenesis


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: MADISON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative A defining requirement for life is the efficient and accurate copying of the cellular genome, and perturbations in single steps of this complex, multi-step process can destabilize a cell's genome and contribute to developmental disorders, stem-cell aging, or cancer. Genome duplication relies on specific proteins working precisely with each other and with the genome itself. The goal of this proposal is to understand how the conserved proteins that control the first step of genome duplication in eukaryotic cells are regulated in cells and interact with the genome to promote and maintain cell health and identity.

PI_NAMEs: FOX, CATHERINE A (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Base Pairing;Binding Proteins;Biochemical;Cell Cycle;Cell division;Cell Proliferation;Cells;Chromatin;Chromatin Structure;chromosomal location;Chromosome Structures;Chromosomes;Collaborations;Complex;Defect;Development;developmental disease;DNA;DNA biosynthesis;Environment;Eukaryotic Cell;G1 Phase;Genetic;Genome;Genome Stability;Genomics;Goals;Health;Heterogeneity;in vivo;Laboratories;Licensing;Life;Malignant Neoplasms;Mediating;Molecular;Organism;Process;Proteins;Reaction;Regulation;Replication Initiation;S phase;Saccharomyces cerevisiae;stem cell aging;Structure;Supporting Cell;Work;Yeasts

PROJECT_TITLE: Chromosome structure, duplication and stability in yeast

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: HD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: EAST LANSING

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Research into both animal and human reproductive biology has widespread implications for human health. The Reproductive and Developmental Sciences Training Program (RDSTP) at Michigan State University seeks to continue training young scientists to have the ability to succeed and establish careers critical to research priorities established for the reproductive sciences as well as alternate careers that will enhance the field.

PI_NAMEs: FAZLEABAS, ASGERALLY T.;LATHAM, KEITH E (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TITLE: Reproductive and Developmental Sciences Training Program - T32


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The research proposal focuses on modeling a subset of human liver cancers for better understanding and therapeutics. This proposal will assess the relevance of combinations of various oncogenes that are found in patients by generating relevant models and testing innovative therapies which will form the basis for precision medicine in this tumor type.

PI_NAMEs: LUJAMBIO, AMAIA ;MONGA, SATDARSHAN SINGH (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: anti-PD-1;anti-PD1 therapy;Antigens;BAY 54-9085;beta catenin;Biological Markers;Biology;Cancer Model;Cancer Patient;Cellular Metabolic Process;Characteristics;chronic liver disease;Cirrhosis;Clinic;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Combination immunotherapy;combinatorial;Combined Modality Therapy;comparative efficacy;CTNNB1 gene;Data;Databases;Death Rate;Dependence;design;Development;effective therapy;Enterobacteria phage P1 Cre recombinase;Environment;Excision;FDA approved;FRAP1 gene;gain of function mutation;Gene Expression;Gene Expression Profiling;Genes;Genetic;genome wide association study;Glutamate-Ammonia Ligase;Glutamates;Glutaminase;Glutamine;Hepatocyte;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;immunogenic;Incidence;inducible Cre;inhibitor;Injections;Innovative Therapy;Knockout Mice;lipid nanoparticle;liver transplantation;loss of function mutation;Malignant neoplasm of liver;Malignant Neoplasms;Medical;men;Methionine Sulfoximine;MLL2 gene;Modeling;Molecular;mortality;mouse model;mTOR inhibition;mTOR Inhibitor;Mus;mutant;Mutate;Mutation;Neoadjuvant Therapy;neoplastic cell;Nivolumab;novel;Oncogenes;Oncogenic;Other Genetics;overexpression;palliation;Pathway interactions;patient subsets;Patients;PD-1 inhibitors;personalized medicine;Phenotype;Pre-Clinical Model;precision medicine;Precision therapeutics;predicting response;Predisposition;Primary carcinoma of the liver cells;Production;programmed cell death protein 1;promoter;Public Health;Publications;Publishing;Regulation;Reporting;Research Proposals;Resistance;response;response biomarker;Risk Factors;Role;Sampling;SDZ RAD;SEER Program;Sirolimus;Sleeping Beauty;Small Interfering RNA;Tail;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;TP53 gene;Transposase;tumor;Tumor Immunity;tumor initiation;tumor metabolism;tumor-immune system interactions;tumorigenesis;Unresectable;Veins;Woman

PROJECT_TITLE: Targeting tumor metabolism and immune environment via beta-catenin: Towards precision medicine in HCC

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Liver Disease;Microbiome;Nutrition;Prevention;Substance Misuse

PI_NAMEs: FENG, WENKE  (contact)

PROJECT_TERMS: Acute;Agonist;alcohol abuse therapy;alcohol exposure;Alcohol-Induced Disorders;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Bacteria;Bacterial Translocation;Bilophila wadsworthia;Biological Markers;Cells;Chronic;Clinical;clinical application;Development;Digestive System Disorders;Disease;disorder prevention;dysbiosis;Endocytosis;Environment;Epithelial Cells;Epithelium;Evaluation;exosome;Experimental Models;Functional disorder;Future;Ginger;Growth;gut colonization;gut inflammation;gut microbes;gut microbiota;Homeostasis;improved;interleukin-22;intestinal barrier;intestinal epithelium;Intestines;islet;Mediating;metabolomics;microbial;mouse model;Mus;nanoparticle;National Institute on Alcohol Abuse and Alcoholism;Natural regeneration;nutrition;organ injury;Outcome;Oxidative Stress Induction;pathogenic bacteria;Pathogenicity;Pathway interactions;Patients;Play;prebiotics;prevent;Prevention;probiotic therapy;Probiotics;Production;programs;protective effect;Receptor Signaling;Regenerating islet derived protein 3-Gamma;Role;Signal Transduction;stool sample;Testing;Therapeutic Effect;Tight Junctions;transcytosis;Tryptophan;Up-Regulation

PROJECT_TITLE: Probiotic-derived nano-particles in alcoholic liver disease


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Selfish meiotic drive loci are poorly-understood genetic elements with non- intuitive activities, and can gain unfair transmission into the next generation even though their activities can be deleterious. We discovered that quickly-evolving small interfering RNA loci defend against de novo meiotic drive loci in testis. Our proposed studies of these intragenomic battles, using invertebrate and vertebrate systems, will elucidate new concepts in the fields of small RNA biology, spermatogenesis, reproductive isolation and evolution.

PI_NAMEs: LAI, ERIC C (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Antidotes;Arthropods;ATAC-seq;Binding;Biochemical;Biological;Biology;Breeding;Catalysis;causal variant;Cellular Assay;Chromatin;Chromosomes;Cleavage Under Targets and Release Using Nuclease;comparative genomics;Conflict (Psychology);Data;Defect;Dependence;Drosophila genus;Elements;Equilibrium;Evolution;Exhibits;Family;Fertility;fitness;Foundations;Gene Amplification;Gene Family;gene product;Genes;Genetic;genetic element;Genome;Genomics;Germ Lines;Hand;Histones;Impairment;in vivo;Individual;innovation;Insecta;insight;Invertebrates;Investigation;Knock-out;Laws;Left;Legal patent;Life;Link;Logic;Maintenance;male;Male Sterility;Mammals;Maps;Meiosis;Modeling;Molecular;mouse model;multidisciplinary;Mus;mutant;next generation;novel;Nuclear Family;pandemic disease;Paper;Pathway interactions;Phenotype;Play;Population;posttranscriptional;preservation;pressure;Protamines;Proteins;Proteome;Proteomics;Recurrence;Repression;reproductive;RNA;RNA Interference;Role;Selfish Genes;sex;Sex Bias;Sex Chromosomes;Sex Ratio;Small Interfering RNA;Small RNA;Son;Source;sperm cell;Spermatogenesis;Spermiogenesis;Sterility;System;Taxonomy;Testing;Testis;Tissues;tool;transcriptome;transcriptome sequencing;transmission process;Work

PROJECT_TITLE: Essential roles for RNAi/hpRNAs to resolve intragenomic conflicts in the male germline

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-P(02)M]


ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PI_NAMEs: KENNEDY, MARY B;SEJNOWSKI, TERRENCE J (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Affinity;AMPA Receptors;autism spectrum disorder;Binding;Binding Proteins;Biochemical;Brain;calmodulin-dependent protein kinase II;Child;cognitive disability;Complex;computational neuroscience;Computer Models;Core Protein;Cytosol;Dendrites;Dendritic Spines;density;Diffuse;Diffusion;DLG4 gene;Electrophysiology (science);Elements;Engineering;Enzymes;Epilepsy;Equilibrium;Excision;experimental study;Fluorescence Microscopy;Genetic;Glutamate Receptor;Glutamates;Goals;Guanosine Triphosphate Phosphohydrolases;improved;In Vitro;Instruction;Intellectual functioning disability;International;Intervention;Joints;Laboratories;Learning;Ligand Binding Domain;Ligands;Liquid substance;Measurement;Measures;Medical;Membrane;Memory;Mental disorders;Mental Health;Methods;Mission;Modeling;Molecular;Mutate;Mutation;N-Methylaspartate;nano;nanoscale;National Institute of Mental Health;Neurons;Patients;Phase;Phosphorylation;Physical condensation;Play;postsynaptic;presynaptic;programs;Property;Protein Binding Domain;protein complex;Proteins;receptor;receptor binding;Recording of previous events;Regulation;Research;response;Role;scaffold;Scaffolding Protein;Signal Transduction;Site;superresolution microscopy;Surface;Synapses;Synaptic Membranes;Synaptic plasticity;Synaptic Transmission;synergism;Therapeutic;trafficking;two-dimensional;ultra high resolution;United States National Institutes of Health;Universities;Vertebral column;Vision;Work

PROJECT_TITLE: CRCNS: Regulation of assembly and disassembly of the postsynaptic density during synaptic plasticity and its effect on AMPAR trapping


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: NARRATIVE This proposal focuses on the development of chemical tools to study protein citrullination which is aberrantly increased in autoimmunity and cancer. These tools will be used to identify citrullinated proteins and understand how citrullination contributes to human biology and disease.

PI_NAMEs: THOMPSON, PAUL R (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Address;Affect;Animal Model;Autoimmunity;Biology;Chemicals;chemoproteomics;citrullinated protein;Communities;Development;Disease;Event;Genetic Code;Goals;Human;Human Biology;human disease;Individual;Inflammatory;inhibitor;insight;Isoenzymes;Leadership;Malignant Neoplasms;nerve damage;new therapeutic target;Outcome;Pathogenesis;Positioning Attribute;Post-Translational Protein Processing;Protein Inhibition;Protein-arginine deiminase;Proteins;Research;Rheumatoid Arthritis;Severity of illness;Signal Transduction;tool;translational impact;Ulcerative Colitis

PROJECT_TITLE: Chemical probes to decipher PAD biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(07)R]


NIH_SPENDING_CATS: Genetics

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Defects in cellular polarity are associated with numerous neurological disorders, kidney diseases, and cancer. In many cell types, polarity is established by the motor-driven localization of RNAs, proteins and vesicles to distinct regions within the cell. This proposal seeks to understand the molecular mechanism by which cell polarity is established and the role of motor proteins in this process.

PI_NAMEs: GONSALVEZ, GRAYDON  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Binding Proteins;Biochemical;Biotin;Cell Polarity;cell type;Cells;Complex;Coupled;Defect;developmental disease;Drosophila melanogaster;egg;Embryo;Epithelium;falls;fly;Human;Kidney Diseases;Knowledge;Life;Ligation;Link;Maintenance;Malignant Neoplasms;Mammals;messenger ribonucleoprotein;Messenger RNA;Modeling;Molecular;Molecular Motors;Motor;Nature;Nervous System Disorder;Neurons;novel strategies;Organelles;Organism;particle;Prevalence;Process;protein complex;Protein Sortings;Proteins;RNA;RNA-Protein Interaction;Role;Site;Structure;Testing;Translational Regulation;Translations;Vesicle;Yeasts

PROJECT_TITLE: Molecular mechanisms underlying the establishment of cell polarity.

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Liver Disease;Microbiome;Nutrition;Substance Misuse

PI_NAMEs: ZHANG, XIANG  (contact)

PROJECT_TERMS: Acetylation;Affinity;alcohol research;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Analytical Chemistry;Bacteria;Bilophila wadsworthia;Bioinformatics;Biological;Biometry;Broccoli - dietary;Butyrates;Cecum;Chromatography;Complex Mixtures;Consumption;Data Collection;Data Reporting;data sharing;design;Development;efficacy evaluation;Enhancers;Ensure;Epigenetic Process;Ethanol;exosome;Family;Feces;follow-up;FOXP3 gene;Functional disorder;Ginger;Glutathione;Goals;gut dysbiosis;gut microbiota;Heavy Drinking;Human;Human Resources;IL17 gene;Immunoglobulin Class Switching;Individual;Inflammatory;inflammatory milieu;Infrastructure;Institution;instrument;interleukin-22;Intestines;Lactobacillus casei rhamnosus;lipid mediator;lipidomics;Lipids;Liver;Liver Dysfunction;liver injury;Mass Spectrum Analysis;Measures;Mediating;Mediator;member;metabolomics;method development;Methods;microbial;Molecular Evolution;Monitor;multidisciplinary;Mus;nanoparticle;novel;novel therapeutic intervention;nutrition;organ injury;pathogenic bacteria;Pathogenicity;Pathway interactions;Patients;Peptides;Performance;Phosphorylation;Plasma;Play;Post-Translational Protein Processing;Preparation;prevent;Probiotics;Production;protective effect;Protein Analysis;Protein Fragment;Proteins;Proteomics;Protocols documentation;Reaction;Research;Research Personnel;Resolution;Resources;Role;sample collection;Sampling;Science;sex;Stable Isotope Labeling;Standardization;STAT3 gene;stool sample;success;T-Lymphocyte;Techniques;Technology;teratogenesis;Testing;Therapeutic Intervention;Time;Tissue Sample;Training and Education;transcription factor;Translational Research;treatment group;Tryptophan;Universities;Variant;Volatile Fatty Acids

PROJECT_TITLE: Omics Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Aging is associated with deficits in trust-related decision making, contributing to the growing public health problem of elder fraud. This project will (i) characterize basic neurocognitive processes in learning to trust in aging; and (ii) determine if trust-related decision making can be optimized via neurofeedback training.

PI_NAMEs: EBNER, NATALIE C (contact);LIGHTHALL, NICHOLE ;WILSON, ROBERT C

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Address;Adult;Affective;Age;age related;age related neurodegeneration;Aging;aging related;Alzheimer's Disease;Amygdaloid structure;Anterior;Arizona;Basic Science;brain behavior;cingulate cortex;Clinical;Cognition Disorders;Cognitive;cognitive function;cognitive process;computational neuroscience;Computer Models;Control Groups;COVID-19 pandemic;Cues;Data;Decision Making;distrust;Elderly;Emotional;experience;experimental study;Family history of;Financial Hardship;Florida;Foundations;Fraud;Functional Magnetic Resonance Imaging;Future;Gambling;Geriatric Assessment;Goals;Health;healthy aging;Human;human old age (65+);Impaired cognition;Impairment;improved;Individual;innovation;Insula of Reil;interdisciplinary approach;Intervention;Investigation;Iowa;Learning;Life;life span;Link;Measures;Mediating;Memory;Methodology;middle age;neural;neural circuit;neural correlate;Neurocognitive;neuroeconomics;neurofeedback;neuroimaging;neuromechanism;Neuropsychology;neurotransmission;novel;older adult;Older Population;Outcome;Pathology;Pathway interactions;phishing;Play;pre-clinical;Predisposition;Process;Public Health;Research;Research Project Grants;response;Risk;Role;Sampling;Signal Transduction;social;Social Interaction;Social Sciences;Societies;System;Techniques;Testing;theories;theory of mind;Time;Training;translational potential;Trust;trustworthiness;Up-Regulation;Update;Work;young adult

PROJECT_TITLE: Characterizing and modulating neurocognitive processes of learning to trust and distrust in aging

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Kidney Disease;Nutrition

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative/Public Health Relevance Statement High salt consumption in the Western diet leads to inflammation and cardiovascular disease but the mechanisms are not known. A major problem with excess dietary intake is salt sensitivity of blood pressure, which is an increase or decrease in blood pressure when salt intake increases or decreases respectively, and is an independent predictor of death due to cardiovascular disease. Our proposed studies to determine the interplay between immune cell activation and tissue sodium accumulation in contributing to salt sensitivity of blood pressure may lead to better diagnosis and treatment of this important risk factor.

PI_NAMEs: KIRABO, ANNET  (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: absorption;Acute;adduct;Adoptive Transfer;Adult;Amiloride;Antigen Presentation;Antigen-Presenting Cells;Autologous;bench to bedside;Binding;Blood Glucose;Blood Plasma Volume;Blood Pressure;blood pressure elevation;Calcium;Cardiovascular Diseases;cardiovascular risk factor;Cell Physiology;Cells;Cessation of life;Cholesterol;Classification;Clinic;Consumption;cost effective;cytokine;Data;Dendritic Cells;Diagnosis;Diagnostic;Diagnostic tests;diagnostic tool;dietary;dietary excess;Dietary intake;Disease;Electrostatics;endothelial dysfunction;epithelial Na+ channel;Essential Hypertension;Excretory function;experimental study;Exposure to;Extracellular Fluid;Future;Glycosaminoglycans;Goals;graft vs host disease;high body mass index;Human;humanized mouse;hypertensive;Immune;immune activation;immunodeficiency;Immunodeficient Mouse;Immunology;In Vitro;in vivo;Individual;Infiltration;Inflammation;Inpatients;insight;interstitial;Investigation;Kidney;kidney dysfunction;Knockout Mice;Lipids;Magnetic Resonance Imaging;Measures;Mediating;metabolomics;migration;monocyte;mortality;Mus;Muscle;NADPH Oxidase;neoantigens;normotensive;Organ;oxidation;Participant;Pathogenesis;Patients;personalized diagnostics;personalized therapeutic;Persons;Phenotype;Play;Proliferating;Proteins;Proteomics;Protocols documentation;public health relevance;Pulse Pressure;Regulation;renal damage;Research;Resistance;response;Risk Factors;Role;salt intake;salt sensitive;salt sensitive hypertension;Sampling;Scientist;Sgk protein;Skin;Sodium;Sodium Chloride;success;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapy development;Tissues;trait;transcriptomics;translational study;Vascular Diseases;Water;western diet

PROJECT_TITLE: Immune Mechanisms of Salt-Sensitive hypertension

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


NIH_SPENDING_CATS: Aging;Back Pain;Chronic Pain;Clinical Research;Genetics;Neurosciences;Pain Research

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: PROJECT NARRATIVE Aging is a major risk factor for spinal disc degeneration and associated chronic back pain, a significant disease burden but with no effective treatments. Understanding the molecular and cellular basis of disc development and age-associated changes will help develop therapeutics for disc pathologies. The proposed study aims to understand the role of crucial developmental signaling pathways in postnatal disc growth and maintenance and test its beneficial potential in preventing and reversing age-associated degenerative changes in the disc.

PI_NAMEs: DAHIA, CHITRA L (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Ablation;Acceleration;Adult;Adverse effects;Affect;Age;age related;age related changes;age related decline;Aging;aging population;aging process;Area;Birth;Blood;burden of illness;cartilaginous;Cell Physiology;Cell Proliferation;Cells;chronic back pain;Chronic Disease;Clinical;cohort;Data;Data Set;Degenerative Disorder;Development;Developmental Process;Down-Regulation;effective therapy;Elderly;Embryo;Embryonic Development;Erinaceidae;Event;Extracellular Matrix;Extracellular Matrix Proteins;Financial Hardship;Foundations;Genetic;Genetic Transcription;Giant Cells;Goals;Growth;Health;Heterogeneity;Human;improved;In Vitro;in vivo;Individual;infancy;insight;Intervertebral disc structure;intervertebral disk degeneration;Joints;juvenile animal;knock-down;Knowledge;Lateral;Lead;Learning;Ligands;Longevity;Maintenance;Maps;Modeling;Molecular;Molecular Profiling;mouse model;Mus;Nervous System Disorder;notochord;novel;nucleus pulposus;old mice;Organ Culture Techniques;organ growth;overexpression;pathological aging;Pathology;Pathway interactions;Pattern;Phenotype;Physiological;Play;Population;postnatal;prevent;Production;Publishing;Quality of life;Regulation;Research;Resolution;Risk Factors;Role;Sampling;Serum;SHH gene;Signal Pathway;Signal Transduction;skeletal;small molecule;smoothened signaling pathway;spatiotemporal;Spinal;stem cells;Testing;Therapeutic;Time;Tissues;transcriptome;transcriptome sequencing;transcriptomics;vertebra body

PROJECT_TITLE: Role of Developmental Signaling Pathways in Maintenance of Spinal Discs

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Clinical Research;Health Services;Infant Mortality;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: HANOVER

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE The health of newborns and infants is fundamental to health across the lifespan. This study of all newborns in a large, diverse birth cohort will advance our fundamental understanding of perinatal health care disparities during the first year of life, both for very preterm births and infants at lower risk. The knowledge gained will support development of new clinical improvement initiatives and perinatal care policies.

PI_NAMEs: GOODMAN, DAVID C. (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Admission activity;Adult;Age;Area;Beds;beneficiary;Birth;Birth Weight;California;care delivery;care systems;Caring;Characteristics;Child;Childhood;Chronic lung disease;Clinical;clinical care;cohort;Complex;Country;Data Set;design;Development;Diagnosis;Enrollment;Environment;Ethnic Origin;extreme prematurity;Family;Florida;Gestational Age;Goals;Growth;Health;health care delivery;health care disparity;health empowerment;Health Policy;Health Services;Health system;Healthcare;high risk;hospital care;hospital readmission;Hospitals;Image;improved;improved outcome;Income;Infant;Infant Care;Infant Health;inpatient service;Inpatients;Intervention;Knowledge;Length of Stay;Life;Life Cycle Stages;life span;Link;Measurement;Measures;Medicaid;Medical;Medicare;member;Monitor;Morbidity - disease rate;mortality;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;Nature;Neonatal;neonatal care;neonatal health;Neonatal Intensive Care Units;neonatal outcome;neonatal services;Newborn Infant;Nutritional;Outcome;outcome prediction;Patterns of Care;Perinatal;Perinatal Care;perinatal health;perinatal outcomes;Policies;Policy Developments;Population;population based;Population Heterogeneity;Pregnancy;premature;Premature Birth;programs;Provider;Quality of Care;Race;Records;Research;Resources;Retinopathy of Prematurity;Risk;Risk Adjustment;Services;Testing;Texas;United States;Variant;Vermont;Very Low Birth Weight Infant;Weight;Woman;Work

PROJECT_TITLE: Determinants of Newborn Health and Health Care Trajectories in the First Year of Life

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Posttraumatic stress disorder (PTSD) is a debilitating condition characterized by altered neural circuitry and it is twice as common among women compared to men. The current study will use high-density EEG to probe resting state and event-related neurophysiological deficits in PTSD, as well as estradiol and progesterone assays to determine the moderating effect of menstrual cycle phase on these phenomena. By leveraging advanced EEG techniques and hormone assay, this study will ultimately contribute to the personalization of PTSD treatments for women.

PI_NAMEs: SELIGOWSKI, ANTONIA  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Anterior;Aversive Stimulus;Behavior;Biological Assay;Blood specimen;Brain;brain circuitry;cingulate cortex;comparison control;Complex;conditioned fear;conditioning;Data;density;Dorsal;Electrodes;Electroencephalography;Electromagnetics;emotion regulation;Emotional;Emotions;Estradiol;Event;Exhibits;experience;Frequencies;Fright;Goals;Hormones;improved;Individual;individualized medicine;Investigation;Learning;Luteal Phase;Measures;men;Menstrual cycle;Mentorship;Methods;Modeling;multimodality;National Institute of Mental Health;neural;neural circuit;neurophysiology;paired stimuli;Participant;personalized approach;Phase;Physiological;Population;Post-Traumatic Stress Disorders;Prefrontal Cortex;Progesterone;proliferative phase Menstrual cycle;Research;Resolution;response;Rest;Risk;Role;Sampling;Scalp structure;Serum;Sex Differences;Signal Transduction;Source;source localization;Standardization;Stimulus;Strategic Planning;System;Techniques;temporal measurement;Testing;tomography;Training;translational research program;trauma exposure;Woman;women versus men;Women's prevalence;women's treatment

PROJECT_TITLE: A Multi-Modal Investigation of Neurophysiological Deficits in PTSD

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Genetics;Human Genome;Osteoarthritis;Precision Medicine;Rheumatoid Arthritis

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative Rheumatoid arthritis (RA) is an immune-mediated disease affecting diarthrodial joints that remains an unmet medical need despite improved therapy. We will generate omics data and perform integrative analysis to provide molecular characterization of RA and individual patients, which will pave the way towards developing precise and personalized therapy.

PI_NAMEs: FIRESTEIN, GARY S;WANG, WEI  (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Affect;Aggressive behavior;ATAC-seq;Binding;Biological;Biological Assay;Biological Process;Biological Products;Biopsy;Cartilage;Cell Lineage;Chromatin;computational pipelines;cost;Critical Pathways;Data;data integration;Data Set;Degenerative polyarthritis;Development;differential expression;Diffuse;Disease;DNA;DNA Methylation;effective therapy;Effector Cell;Enhancers;Environmental Risk Factor;Enzymes;Epigenetic Process;epigenomics;experimental study;Fibroblasts;Genes;Genetic;genetic variant;Genetic Variation;genome sequencing;genome-wide;Hand;Hip Joint;histone modification;Human Genome;Immune;improved;Individual;individual patient;insight;Interleukin-6;joint injury;Joints;Knee;Knee joint;Maps;Measurement;Measures;Mediating;Mediator;Medical;Methods;Methylation;methylome;Modification;Molecular;Names;Natural Immunity;Pathogenesis;Pathogenicity;Pathway interactions;Patients;personalized medicine;Play;Production;promoter;Regulation;Replacement Arthroplasty;response;restraint;Rheumatoid Arthritis;Role;Sampling;Signal Pathway;Surveys;Synovial Membrane;Synovitis;Tai Ji;targeted treatment;Text;Therapeutic Agents;transcription factor;transcriptome;transcriptome sequencing;treatment response;Variant;whole genome;Work;Wrist

PROJECT_TITLE: Identification of key regulators in rheumatoid arthritis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Antibiotic resistant bacteria are a growing global threat to human health and wellbeing. I propose to investigate how the spatiotemporal organization and physiology of gut bacteria could be targeted to stop the emergence and spread of antibiotic resistance. This work will inform the design of new strategies for combating antibiotic resistance through the therapeutic manipulation of the intestinal microbiome’s physical architecture.

PI_NAMEs: WILES, TRAVIS J (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Affect;Agriculture;Animals;Antibiotic Resistance;Antibiotics;Architecture;Attention;Bacteria;Bacterial Antibiotic Resistance;bacterial community;bacterial resistance;Bacteriophages;Behavior;Biological Models;Cell Physiology;Cells;Ciprofloxacin;Collection;Combating Antibiotic Resistant Bacteria;Complex;de novo mutation;design;Disease;Dissociation;DNA Damage;Dose;drug development;Ecology;Ecosystem;Elements;Environment;Environmental Risk Factor;Evolution;experimental study;fighting;Food Supply;Future;Genetic;Genetic Engineering;genetic manipulation;gut bacteria;gut microbiome;Health;Horizontal Gene Transfer;Human;Image;In Situ;In Vitro;Individual;Infection;innovation;Intestines;Livestock;Memory;Methods;Microbe;microbial;microbiota;Mobile Genetic Elements;Modeling;Molecular;molecular scale;Motility;Motivation;Movement;Mus;Mutation;Nature;novel;Optics;pathogen;Pathway interactions;Personal Satisfaction;Pharmaceutical Preparations;Physical shape;Physiological;Physiology;Plasmids;preservation;prevent;Production;public health intervention;Reporter;Research;Resistance;resistance gene;Resolution;response;side effect;Signal Pathway;SOS Response;spatiotemporal;Structure;Swimming;synthetic biology;System;Testing;Therapeutic;Time;Tissues;tool;trait;transmission process;Work;Zebrafish

PROJECT_TITLE: Connecting the Spatiotemporal Organization of Gut Bacterial Communities to the Emergence and Spread of Antibiotic Resistance


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: CHICAGO

ORG_NAME: CHICAGO BIOSOLUTIONS, INC.

ORG_STATE: IL

PHR: Project Narrative This project is to discover and develop small molecule entry inhibitors for influenza viral infection. The proposed research will help to develop potential antiviral therapeutics.

PI_NAMEs: RONG, LIJUN  (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: Acute;Address;Affinity;Amantadine;analog;Animal Model;anti-influenza;Anti-viral Agents;Antidotes;Binding;Biochemical;Biological;Biological Assay;Canis familiaris;Characteristics;Chemicals;Clinical Research;Code;Communicable Diseases;Crystallization;design;Development;Dose;Drug Design;drug development;Drug Kinetics;effective therapy;Effectiveness;efficacy evaluation;endonuclease;Epidemic;Evaluation;Exhibits;experimental study;Family;Future;Genome;genotoxicity;Goals;Hemagglutinin;Immunocompromised Host;improved;In Vitro;in vivo;in vivo evaluation;Infection;Influenza;Influenza A virus;Influenza A Virus, H5N1 Subtype;influenza infection;influenza M2;Influenza Therapeutic;influenza virus strain;inhibitor;Integration Host Factors;ion channel blocker;Lead;lead optimization;Libraries;Life Cycle Stages;Maximum Tolerated Dose;Mediating;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutation;nanomolar;Neuraminidase inhibitor;neutralizing antibody;novel therapeutics;Oral;Orthomyxoviridae;Oseltamivir;pandemic disease;pandemic influenza;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Pharmacology and Toxicology;Phase;piperidine;Plasma;Polymerase;pre-clinical;preclinical development;Property;prophylactic;Proteins;Rattus;Recommendation;Research;Resistance;resistant strain;Resolution;Rimantadine;RNA;Rodent;Route;Safety;safety study;safety testing;scaffold;seasonal influenza;Series;Small Business Technology Transfer Research;small molecule;small molecule inhibitor;Specificity;Structure;Structure-Activity Relationship;Surface;synergism;targeted treatment;Testing;Therapeutic;Therapeutic Uses;Time;Toxic effect;Toxicokinetics;Toxicology;Treatment Efficacy;Vaccination;Vaccines;Viral;Virulent;Virus;Virus Diseases;Virus Replication;X-Ray Crystallography;zanamivir

PROJECT_TITLE: Development of 4-(aroylamino)piperidine-based entry inhibitors as anti-influenza therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-A(10)B]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Digestive Diseases;Mental Health;Microbiome;Pain Research;Prevention

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: PROJECT NARRATIVE There has been significant recent public and research interest in Mindfulness-Based Interventions (MBIs). But little is known about what active components of MBIs might be linked with stress reduction and health outcomes in at risk patient populations. The broad objective of this project is to test a new mechanistic account of the active components of MBIs in Irritable Bowel Syndrome patients.

PI_NAMEs: CRESWELL, JOHN DAVID (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Abdominal Pain;active method;Adopted;Adult;Affect;Aftercare;arm;Attention;Attitude;Automobile Driving;Behavior Therapy;Brain;Cellular Phone;Communities;Control Groups;coping;Data;Disease;Disease Outcome;Distress;Ecological momentary assessment;Educational Intervention;Elements;Emergency Situation;Enrollment;Evaluation;Event;Evidence based intervention;Evidence based treatment;Expectancy;experience;follow-up;Fostering;Functional disorder;Functional Gastrointestinal Disorders;gut microbiome;gut microbiota;Habits;Health;Health Benefit;improved;instructor;interest;intervention delivery;intervention program;Intervention Trial;Intestines;Irritable Bowel Syndrome;Learning;Life;Life Stress;Link;Measures;Mediating;metabolomics;mindfulness;mindfulness intervention;mindfulness meditation;Mindfulness Training;mindfulness-based stress reduction;Modeling;Monitor;North America;Outcome;Participant;Pathway interactions;patient population;Patient Self-Report;Patients;Persons;Physicians;Play;post intervention;programs;Publishing;Randomized;Randomized, Controlled Trials;reduce symptoms;Reporting;Research;response;Risk;Role;Sample Size;Sampling;skills;skills training;stool sample;Stress;stress management;stress reduction;stress resilience;stress symptom;symptomatic improvement;Symptoms;Testing;theories;Time;Training;Training Programs;Translational trial;volunteer

PROJECT_TITLE: Mindfulness meditation training for Irritable Bowel Syndrome

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Peripheral Neuropathy;Rare Diseases

ORG_CITY: STURGIS

ORG_NAME: MAGGIE'S PEARL, LLC

PHR: NARRATIVE Congenital Disorders of Glycosylation (CDG) affects several thousand patients worldwide. Maggie’s Pearl has discovered several compounds, including the known drug Epalrestat, that appear to relieve the cause of the disease. The proposed SBIR study will fund a 30-patient, double blind, single-crossover trial to confirm the safety and efficacy of Epalrestat in one form of CDG.

PI_NAMEs: PERLSTEIN, ETHAN  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: 7 year old;Acetazolamide;Address;Adult;Adverse effects;Adverse event;Affect;Age;Alanine Transaminase;Aldehyde Reductase;Animal Model;Antithrombin III;Aspartate Transaminase;Ataxia;Biological Assay;care providers;Caring;Charcot-Marie-Tooth Disease;Chemistry;Child;Childhood;Climacteric;Clinic;Clinical;Clinical Research;Clinical Trials;commercialization;Complete Blood Count;Congenital disorders of glycosylation;Cross-Over Trials;Data;Defect;Development;Diabetic Neuropathies;dietary supplements;Disease;Disease Progression;Documentation;Double-Blind Method;drug candidate;Drug Kinetics;Economics;effective therapy;Elasticity;enzyme activity;Enzymes;Failure to Thrive;FDA approved;Fibroblasts;Fucose;Funding;Future;Galactose;Genotype;Growth;Hematology;Hepatic;hereditary neuropathy;Human;improved;improved outcome;In Vitro;infancy;inhibitor;International;International Normalized Ratio;Japan;kidney dysfunction;L-Iditol 2-Dehydrogenase;Language Delays;Libraries;Life;link protein;Lipids;Liver;mannose 1-phosphate;mannose 6 phosphate;manufacture;Measurement;Measures;Mental disability;Metabolic;Metabolic syndrome;model organism;Modeling;Molecular Chaperones;Monosaccharides;Motor;Muscle hypotonia;mutant;Mutation;Myocardial dysfunction;Neurologic;Neuropathy;novel;Oral;Oral Administration;Orphan Drugs;Palliative Care;Pathogenicity;Pathology;patient population;Patient-Focused Outcomes;Patients;pediatric patients;Peripheral Nervous System Diseases;Pharmaceutical Preparations;Phase;Phosphomannomutase;physically handicapped;polyol;Polysaccharides;prevent;prospective;Protein Glycosylation;Proteins;Prothrombin time assay;Psyche structure;Rare Diseases;Replacement Therapy;Safety;Serum;Severities;Severity of illness;Small Business Innovation Research Grant;stem;success;Symptoms;Testing;Therapeutic;total measurement Bilirubin;Transferrin;Urine;Walking

PROJECT_TITLE: Targeting aldose reductase: A Phase IIb/III trial for the novel use of Epalrestat to treat Congenital Disorders of Glycosylation (PMM2-CDG)


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Psychosis;Racial and Ethnic Minority Health Research;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: PULLMAN

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: PROJECT NARRATIVE  The proposed study is highly relevant to public health because of its focus on reducing inequities in mental health service utilization among Black individuals and their families. This proposed study will develop a culturally informed Family Peer Navigator model for Black/African American youth and their families, and evaluate its acceptability, feasibility, and appropriateness in coordinated specialty care programs. With the goal of providing services early in the pathway to care for psychosis to increase access and initial engagement in coordinated specialty care programs.

PI_NAMEs: OLUWOYE, OLADUNNI  (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: 20 year old;active control;Address;Administrator;African American;African American population;Area;Black Populations;Black race;care coordination;care providers;Caring;Clinical;Communities;community advisory board;Coordinated Specialty Care;Data;design;Development;Diagnosis;Discrimination;disparity reduction;duration of untreated psychosis;early psychosis;Effectiveness;effectiveness/implementation hybrid;Enrollment;Equity;ethnic disparity;ethnic minority;Ethnic Origin;evidence base;Evidence based treatment;experience;Family;Family member;Feedback;first episode psychosis;Formulation;functional outcomes;Goals;Health;Health Personnel;health service use;Health Services Research;implementation outcomes;implementation process;implementation strategy;Improve Access;improved;Individual;Inequity;informant;innovation;Intake;Intensive Care;Intervention;Intervention Studies;Interview;Knowledge;loved ones;Mental Health;Mental Health Services;Methods;model design;Modeling;National Institute of Mental Health;Outcome;Pathway interactions;peer;Persons;Phase;pilot test;pilot trial;Play;Population Heterogeneity;Process;programs;Provider;psychiatric symptom;psychoeducation;Psychoses;psychosis risk;Public Health;Quality of life;Race;racial disparity;racial minority;Randomized;randomized trial;recruit;Reporting;Research;Research Support;Role;Sampling;Schizophrenia;Self Efficacy;Services;social;Telephone;telephone based;theories;Time;Training;treatment comparison;Washington;Youth

PROJECT_TITLE: A Family Peer Navigator Model to Increase Access and Initial Engagement in Coordinated Specialty Care Programs Among Black Families

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Overall: Project Narrative We propose to combine gene engineering of both arms of the adaptive immune response to provide long lasting and broad anti-HIV-1 responses that are capable of suppressing/eliminating HIV-1 replication, thereby leading to an HIV cure.

PI_NAMEs: CHEN, IRVIN S.Y.;KITCHEN, SCOTT G (contact)

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Ablation;adaptive immune response;Address;Adverse effects;Animal Model;Antibody Formation;arm;Autologous;B-Lymphocytes;Berlin;Binding;Biodistribution;Biology;Blood;CCR5 gene;cell behavior;Cell Transplantation;Cells;cellular engineering;Cellular Immunity;Central Nervous System;chimeric antigen receptor;chimeric antigen receptor T cells;chronic infection;Clinical Research;clinical trial implementation;combination gene therapy;Complement;Development;Differentiated Gene;Disease;Drug or chemical Tissue Distribution;Elements;Engineered Gene;engineered T cells;Engineering;Engraftment;experience;Fred Hutchinson Cancer Research Center;Gene Combinations;Gene Delivery;Gene Modified;gene therapy;gene transplantation for gene therapy;Genetic;Genetic Engineering;Grant;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Highly Active Antiretroviral Therapy;HIV;HIV-1;Homologous Transplantation;Human;humanized mouse;Humoral Immunities;Immune;immune function;Immunity;Immunology;Immunotherapeutic agent;Immunotherapy;in vivo;Infant;Infection;inhibitor;Injections;knock-down;latent HIV reservoir;Lentivirus Vector;London;Macaca mulatta;Malignant Neoplasms;Mediating;Membrane Fusion;Modeling;neutralizing antibody;nonhuman primate;novel;Patients;Phase I/II Clinical Trial;Phase I/II Trial;Plasma;Population;preclinical development;programs;Publishing;Reagent;response;Safety;simian human immunodeficiency virus;Site;small hairpin RNA;stem cell biology;success;T cell therapy;T-Lymphocyte;targeted delivery;Technology;Testing;Therapeutic;therapeutic gene;Therapeutic Studies;Tissues;Transgenes;Transplantation;Treatment Efficacy;tumor;Universities;Variant;vector;Viral;Viremia;Virus;Washington;Work

PROJECT_TITLE: (Attack)2: Genetic engineering of cellular and humoral immunity to cure HIV


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Infertility;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE DNA methylation regulates pluripotency, differentiation and tissue-specific gene expression thus playing a key role in normal development. Dnmt3b is a critical DNA methyltransferase involved in epigenome remodeling soon after conception. Understanding molecular mechanisms utilizing various Dnmt3b activities in embryogenesis, postnatal development and in assisted reproductive technologies will provide fundamental knowledge about processes governing mammalian development and may lead to new therapeutic strategies in the future.

PI_NAMEs: OPAVSKY, RENE  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Affect;Assisted Reproductive Technology;Birth;Cells;Centromere;Clinical;Complex;Conceptions;Data;Defect;demethylation;Development;Disease;DNA;DNA Methylation;DNA Modification Methylases;DNA Transposable Elements;DNMT3a;DNMT3B gene;Down-Regulation;Embryo;Embryonic Development;Enhancers;Enzymes;Epiblast;Epigenetic Process;epigenome;Ethics;Family;Fertilization in Vitro;Future;Gene Expression;Gene Expression Regulation;Genes;genetic approach;Genetic Transcription;Genome;genome wide methylation;genome-wide;Genomic Imprinting;genomic locus;Genomic Segment;Genomics;Germ Lines;Health;histone modification;Human;Human Cell Line;Immunoprecipitation;implantation;imprint;In Vitro;in vivo;Individual;Knock-out;Knockout Mice;Knowledge;Large Intestine Carcinoma;Longitudinal Studies;Malignant Epithelial Cell;Measures;Mediating;Medicine;Methylation;methylation pattern;Methyltransferase;Modeling;Modification;Molecular;Molecular Analysis;mouse development;Mouse Embryonic Stem Cells;Mus;novel therapeutic intervention;Pathogenesis;Phenotype;Physiological;Physiological Processes;Play;pluripotency;postnatal development;Pre-implantation Embryo Development;prenatal;prevent;Preventive care;Procedures;Process;promoter;Proteins;recruit;Reporting;Role;Techniques;Testing;Time;Tissue-Specific Gene Expression;Tissues;Totipotency;Transcriptional Regulation;transcriptome sequencing;Western Blotting;X Inactivation

PROJECT_TITLE: Dnmt3b activities in mouse development

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_DEPT: GENETICS

PHR: PUBLIC NARRATIVE Ribosomes are large cellular complexes that synthesize proteins. In addition, ribosomes regulate bacterial stress responses, and human neurodevelopment and synaptic plasticity. Dysregulation of these processes leads to disease. Understanding how ribosomes control gene expression requires high-resolution characterization of ribosome movements and interactions. We will use biochemical and cryo-EM methods to address the mechanisms of translation regulation, which may pave the way to development of therapeutics against bacterial and genetic diseases.

PI_NAMEs: KOROSTELEV, ANDREI  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Amyotrophic Lateral Sclerosis;Antibiotics;Bacteria;Bacterial Infections;Biochemical;biological adaptation to stress;Brain;Cell Nucleus;Cellular Stress;Complex;Cryoelectron Microscopy;Disease;Environment;Eukaryota;Gene Expression;Genetic;Genetic Diseases;Genetic Transcription;Human;In Vitro;Learning;memory consolidation;Messenger RNA;Methods;Molecular;Movement;Nervous System Disorder;neurodevelopment;Neuronal Plasticity;Neurons;Nonsense Codon;novel;Pathway interactions;Positioning Attribute;premature;Process;Protein Biosynthesis;Proteins;Proteome;Resolution;Ribosomal Interaction;Ribosomes;Stress;Synapses;Synaptic plasticity;therapeutic development;Time;Transcriptional Regulation;translation factor;Translational Regulation;Translations;Visualization

PROJECT_TITLE: Translational Control: Discovery and Mechanisms

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Autophagy is a conserved process of cellular recycling that degrades surplus or damaged molecules and organelles, with profound impacts on several areas of human health, from tumorigenesis and cancer cell survival to neurodegeneration, inflammation and aging. Potential therapeutic approaches that involve inhibiting or potentiating autophagy require a greater understanding of the mechanisms by which this process is regulated. Studies outlined in this proposal use a Drosophila model system to identify these key control points, focusing on how the Target of Rapamycin (TOR) pathway is controlled by upstream and feedback signals, and how it controls the trafficking and degradation of autophagic cargo.

PI_NAMEs: NEUFELD, THOMAS P. (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;aged;Aging;Animals;Apoptosis;Area;Autophagocytosis;Autophagosome;Biochemical;Biological Models;Body System;cancer cell;Cell Culture Techniques;Cell Death;Cell Physiology;Cell Survival;Cells;Clone Cells;Complement;Complex;Cues;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cytoplasm;Defect;Development;Disease;Drops;Drosophila genus;Equilibrium;Eukaryotic Cell;Event;experimental study;extracellular;Fat Body;Feedback;fly;G-Protein-Coupled Receptors;Gene Family;Genes;Genetic;genetic manipulation;Genetic Screening;Goals;Health;Human;imaging approach;in vivo;Inflammation;inhibition of autophagy;Insulin Receptor;Knock-out;Link;Lysosomes;Malignant Neoplasms;Mammalian Cell;Measurement;Mediating;Mediator;Membrane;Methods;Nerve Degeneration;novel;Nutrient;nutrition;Organ Culture Techniques;Organelles;Organism;Pathway interactions;Pattern;Phosphorylation;Physiological;Physiological Processes;Play;Process;protein kinase A kinase;Proteins;Proton Pump;Reagent;Recycling;Regulation;response;restoration;restraint;Role;Signal Transduction;Signaling Molecule;Sirolimus;Source;Starvation;Stress;System;Testing;Therapeutic;Tissues;tool;trafficking;tumorigenesis;ubiquitin-protein ligase;vacuolar H+-ATPase;Vesicle;Work;Yeasts

PROJECT_TITLE: Mechanisms of TOR-dependent control of autophagy in Drosophila

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Nutrition;Obesity

PHR: PROJECT NARRATIVE Metabolic problems like obesity, high cholesterol and fatty liver impact an astonishing 100 million adults in the US and are major contributors to morbidity and mortality. We found that chemical modifications of RNA are essential for optimal regulation of lipid metabolism and cellular response to dietary stress. The overarching goal of this proposal is to better understand the function and mechanisms of specific RNA modifications in liver metabolism.

PI_NAMEs: SALLAM, TAMER  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Adult;Affect;Animals;Architecture;Binding;Biological;Biological Assay;Biological Process;Biology;Cardiometabolic Disease;Cardiovascular Diseases;Cells;Chemicals;Cholesterol;Chromatin;Chronic;Data;Diet;dietary;Disease;DNA-Binding Proteins;Enzymes;Epigenetic Process;Exons;experimental study;Fasting;Fatty Liver;fatty liver disease;gain of function;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genomic DNA;genomic locus;Goals;Health;Hepatic;Histones;Homeostasis;in vivo;insight;Knock-out;lipid biosynthesis;lipid metabolism;Lipids;Liver;liver metabolism;Maintenance;Mammalian Cell;Maps;Messenger RNA;Metabolic;Metabolic Control;Metabolic Diseases;Metabolic Pathway;Metabolism;Methylation;methylome;Methyltransferase;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;mRNA Stability;Mus;nonalcoholic steatohepatitis;novel;Obesity;Pathway interactions;Pattern;Physiological;Play;posttranscriptional;promoter;Protein Family;Proteins;Reader;Regulation;Reporting;Resolution;response;ribosome profiling;RNA;RNA metabolism;Role;Series;Site;stem cell division;Stress;Testing;Therapeutic;Tissues;Transcript;Translations;Triglycerides;Untranslated Regions;Viral Vector

PROJECT_TITLE: RNA modification in cardiometabolic disease

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Human Genome;Primary Immunodeficiencies;Rare Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: This study focuses on the mechanisms of action of Aire, the protein encoded by the gene mutated in individuals with APECED (or APS-1), a primary immunodeficiency disease characterized by multi-organ autoimmunity. While APECED patients are rather rare, the Aire pathway – via polymorphisms in either Aire target-loci or in the gene encoding Aire itself – has been implicated in several of the more common autoimmune disorders, including type-1 diabetes, myasthenia gravis, vitiligo and pernicious anemia. Targeting of new cellular and molecular interactions and pathways highlighted in this study may have therapeutic potential; in addition, we should learn about the optimum points for intervening in autoimmune disease course.

PI_NAMEs: MATHIS, DIANE J (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Adult;Age;Antigens;ATAC-seq;Autoimmune Diseases;Autoimmunity;Back;Binding;Biological;CD4 Positive T Lymphocytes;Cell Compartmentation;Cell Lineage;cell type;Cells;Characteristics;Chromatin;Chromatin Structure;Code;conditional knockout;congenital immunodeficiency;Data;Dependence;derepression;Disease;Ectopic Expression;effector T cell;Enhancers;Epithelium;Experimental Designs;Genes;Genetic Polymorphism;Genetic Transcription;Genome;Goals;Histologic;HNF4A gene;Human;Immune Tolerance;Immunization;Individual;Inflammatory;Insulin-Dependent Diabetes Mellitus;interest;Learning;Logic;M cell;Maintenance;Messenger RNA;Modeling;Molecular;mosaic;mouse development;Mus;Mutate;Mutation;Myasthenia Gravis;Organ;Pathway interactions;Patients;Peptides;Perinatal;perinatal period;Peripheral;Pernicious Anemia;Play;Polyglandular Autoimmune Syndrome Type I;Population;prevent;Process;programs;Proteins;Regulatory T-Lymphocyte;Role;Signal Transduction;Signaling Molecule;single cell ATAC-seq;single-cell RNA sequencing;Specific qualifier value;T cell response;T-Lymphocyte;Testing;Therapeutic;Thymic epithelial cell;Thymus Gland;Tissues;Transcript;transcription factor;Transcriptional Activation;Vitiligo;Zinc Fingers

PROJECT_TITLE: Aire, a zinc-finger protein that controls autoimmunity

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Nutrition;Obesity

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative Mitochondria continually generate two types of energy, ATP (the chemical energy of the cell) and heat (called mitochondrial thermogenesis), and a fine balance of energy distribution between these two forms of energy defines metabolic cell homeostasis. Using the novel mitochondrial patch-clamp technique combined with modern cellular and molecular techniques, this project will provide new insights into the mechanisms that control mitochondrial thermogenesis to readjust cell metabolism for therapeutic purposes.

PI_NAMEs: BERTHOLET, AMBRE MARGUERITE SOLANGE (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: 2,4-Dinitrophenol;Acute;age-related disease;Anti-Obesity Agents;Biological Assay;biophysical properties;Body Temperature;Brown Fat;Burn injury;Calories;Cells;Cellular Metabolic Process;Chemical Actions;Chemicals;combat;Cytoprotection;Development;diet-induced obesity;Dinitrophenols;energy balance;Equilibrium;Fatty acid glycerol esters;Homeostasis;Inner mitochondrial membrane;insight;Ion Channel;Measurement;Mediator;Metabolic;Metabolic syndrome;Metabolism;Methodology;Methods;Mitochondria;mitochondrial dysfunction;Modernization;Molecular;novel;Nutrient;oxidative damage;patch clamp;Patch-Clamp Techniques;Pathology;Physiology;prevent;Process;Production;Proteins;Protons;Reactive Oxygen Species;Regulation;Research Project Grants;Resolution;targeted treatment;Techniques;Therapeutic;therapeutic development;Thermogenesis;Time;Tissues;uncoupling protein 1

PROJECT_TITLE: Mechanisms of regulation of mitochondrial H+ leak and thermogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

PHR: PROJECT NARRATIVE Despite extensive advancements in the field of clinical and translational research, numerous roadblocks continue to stand in the way of delivering clinical interventions more efficiently, effectively, and equitably. In this application, Harvard Catalyst is proposed as a clinical and translational science laboratory that will work to develop, demonstrate, and disseminate innovations capable of overcoming these roadblocks and, ultimately, improving human health. Harvard Catalyst will leverage the unique expertise of 17 affiliated, but independent, institutions across the Boston biomedical ecosystem to address these challenges, placing particular emphasis on supporting early stage and underrepresented in medicine investigators and their teams.

PI_NAMEs: NADLER, LEE MARSHALL (contact)

PROGRAM_OFFICER_NAME: HARTSHORN, CHRISTOPHER

PROJECT_TERMS: Acceleration;Address;Adopted;Boston;catalyst;Center for Translational Science Activities;Clinical;Clinical Data;Clinical effectiveness;clinical implementation;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials Network;cohort;Collaborations;Communities;community engagement;Community Health;community partners;Competence;COVID-19 pandemic;Democracy;digital;Ecosystem;education research;education resources;Effectiveness;EHR research;Electronic Health Record;Elements;Equity;equity, diversity, and inclusion;Evaluation;experience;Faculty;first-in-human;Geography;Goals;Health;health inequalities;Health Sciences;Healthcare;Human;improved;Informatics;Infrastructure;innovation;insight;Institution;Institutional Review Boards;interoperability;Intervention;Laboratories;Leadership;Learning;Logic;Measures;Medical;medical schools;Medicine;meetings;Mentors;Methodology;Methods;Modeling;Multi-Institutional Clinical Trial;Ohio;open data;open source;Oregon;Output;patient population;Population Heterogeneity;pre-clinical;Process Assessment;prototype;Public Health Informatics;Public Health Schools;Research;research and development;Research Design;Research Personnel;Resources;Safety;Science;Secure;sharing platform;Special Population;success;tool;Training;translational barrier;Translational Research;Vision;Work

PROJECT_TITLE: Harvard Clinical and Translational Science Center


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health, by identifying gene regulatory mechanisms underlying coronary artery disease and related vascular disease risk. These findings are expected to enhance our understanding of the primary causes of vascular diseases in human populations and ultimately lead to better prediction and therapeutic strategies. Thus, the proposed work is relevant to the part of NIH's mission that pertains to developing fundamental knowledge to reduce the burdens of complex human disease.

PI_NAMEs: MILLER, CLINT L (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Actins;Adopted;advanced disease;Affect;Architecture;arterial remodeling;arterial stiffness;Arteries;Atherosclerosis;Binding;Binding Sites;Biological Markers;Blood Pressure;Blood Vessels;calcification;Candidate Disease Gene;candidate identification;causal variant;Cell Physiology;Cells;Cerebrovascular Circulation;Cervical;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;clinically relevant;cofactor;Complex;Coronary;Coronary Arteriosclerosis;Coronary artery;coronary artery calcification;coronary lesion;Cytoskeleton;Data;Data Set;Deposition;Development;Disease;Disease Outcome;disease phenotype;disorder risk;Dissection;Early treatment;Endothelial Cells;Environmental Risk Factor;epigenomic profiling;Event;Extracellular Matrix;Fibroblasts;Functional disorder;functional genomics;Gap Junctions;gene regulatory network;Gene Structure;Genes;Genetic;genetic association;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genetic Transcription;Genome Mappings;genome wide association study;genome-wide;genomic locus;Genomics;Heterogeneity;Human;human disease;Image;Immune;improved;In Situ;Injury;insight;Intervention Studies;Investigation;knock-down;Knowledge;Label;Lesion;LIM Domain;LIM Domain Protein;Lipids;Maps;Measures;Mediating;Meta-Analysis;Migraine;Mission;Multiomic Data;multiple omics;Mus;Muscle;Myocardial Infarction;novel;Osteoblasts;overexpression;Pathologic;Pathway interactions;patient stratification;Pericytes;Phenotype;Physiological;Play;Population;Prevalence;Prevention strategy;Preventive measure;Process;programs;Proliferating;Protein Family;Proteins;Proteomics;Public Health;Quantitative Trait Loci;Regulation;Regulatory Pathway;Research;response;Risk;Risk Factors;risk variant;RNA;Role;single cell analysis;single cell sequencing;Smooth Muscle Myocytes;Stroke;Supporting Cell;System;Testing;Therapeutic;three dimensional cell culture;Tissues;trait;transcription factor;transcriptome;transcriptome sequencing;transcriptomic profiling;Translating;treatment strategy;United States National Institutes of Health;Validation;Variant;Vascular Diseases;Work

PROJECT_TITLE: Functional genomics investigation of pleiotropic vascular disease loci

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE The most common route of toxicologic exposures is via inhalation yet training in this discipline is lacking nation-wide and is absent in this Appalachian region where significant health disparities and systemic toxicities are rampant due to a plethora of environmental risks and socioeconomic disadvantages. The Center for Inhalation Toxicology and major inhalation exposure research infrastructure anchors and augments the impact of the unique triangulation of the West Virginia University Health Sciences Center, School of Engineering, Hospital, and the National Institute for Occupational Safety and Health. The Predoctoral Training in Systems Toxicology Program will formalize and standardize our already strong training programs in the biomedical sciences and focus on inhalation toxicology research by creating a new generation of young scholars who can address the demand for innovative toxicology research for the greater health benefits of the citizens of West Virginia, Appalachia, and the nation.

PI_NAMEs: NURKIEWICZ, TIMOTHY R (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: pre-doctoral;System;Toxicology;Training

PROJECT_TITLE: Pre-doctoral Training in Systems Toxicology

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Diabetes;Kidney Disease;Neurosciences;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE Chronic kidney disease, affecting one in seven adults, is a major risk factor for adverse health outcomes. Measures of kidney function are currently limited in that they do not accurately represent kidney health or do not detect disease until irreversible damage has occurred. The proposed research introduces an MRI-based method for quantifying renal metabolic rate of oxygen, which is elevated during early diabetic kidney disease and a key cause of kidney hypoxia.

PI_NAMEs: WEHRLI, FELIX W (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Abdomen;Address;Adult;Affect;Albumins;Albuminuria;Animal Model;Attenuated;Benchmarking;Biological Markers;Blood;Blood flow;blood flow measurement;Blood Flow Velocity;Brain;Calibration;Cardiovascular Diseases;cardiovascular risk factor;Cerebrovascular Circulation;Cerebrum;Chronic Kidney Failure;Clinical;Clinical Markers;Creatinine;Data;demographics;deoxyhemoglobin;design;Development;Diabetes Mellitus;diabetic;Diabetic Nephropathy;diabetic patient;Dialysis procedure;Disease;Disease Progression;Early Diagnosis;Early Intervention;Evaluation;Fick method;Filtration;Functional disorder;Future;Glomerular Filtration Rate;Health;Histology;Hour;Human;human subject;Hypoxia;imaging modality;insight;Ionizing radiation;Kidney;Kidney Diseases;kidney dysfunction;kidney imaging;Magnetic Resonance Imaging;Measurement;Measures;metabolic rate;Metabolism;Methods;Microalbuminuria;Monitor;Motion;Non-Insulin-Dependent Diabetes Mellitus;novel;Organ;Outcome;Oxygen;Oxygen saturation measurement;Pathologic;Pathway interactions;Patient Monitoring;Patients;Performance;Phase;Physiologic pulse;Physiological;Pilot Projects;Play;Positron-Emission Tomography;Prediabetes syndrome;Prevalence;Public Health;Pulse Oximetry;radiotracer;Relaxation;renal damage;Renal function;renal hypoxia;Renal Tissue;Reporting;Reproducibility;Research;Risk Factors;Role;Sampling;Scanning;Serum;Signal Transduction;Site;Subtraction Technique;Superior sagittal sinus;Techniques;Technology;Testing;Time;tissue oxygenation;Tissues;Transplantation Surgery;Type 2 diabetic;Urine;Veins;Venous;Water;Work

PROJECT_TITLE: MRI-Based Renal Oximetry in Early Diabetic Kidney Disease

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Racial inequities in health are well-known. While their underlying causes are poorly understood, evidence indicates that our neighborhoods play an important role. We examine the ways in which historical and contemporary features of the neighborhood might change certain molecules related to our genes. It may be that these "epigenomic" changes are the mechanism that link racially unequal neighborhoods to health inequities.

PI_NAMEs: HICKEN, MARGARET TAKAKO (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Address;Adult;Age;age acceleration;aging related;Air Pollution;Area;Biological;Black race;Blood;Cardiovascular Diseases;Chemicals;Chronic;Chronic Disease;Complex;Crows;Data;Data Set;Diabetes Mellitus;Disease;DNA Methylation;early onset;effective intervention;Environmental Epidemiology;Environmental Exposure;Environmental Science;Epigenetic Process;epigenomics;Etiology;experience;Exposure to;Genes;Health;Health and Retirement Study;health inequalities;healthy aging;Hypertension;Immune system;Impaired cognition;Imprisonment;Industrialization;Inequity;innovation;Intervention;Knowledge;Laws;Link;Literature;Measures;member;methylation pattern;Modeling;multi-ethnic;Neighborhoods;older adult;Outcome;Pathway interactions;Pattern;Play;Policies;Pollution;Population;Poverty;Prevalence;Race;racial determinant;racial disparity;Racial Segregation;Research;Resources;Risk;Role;segregation;Site;social;social adversity;Social Environment;social epidemiology;Social Sciences;social stressor;social vulnerability;Source;Stress;stressor;Time;Work

PROJECT_TITLE: DNA methylation in context: Racial inequities in social adversity and vulnerability to the health impact of air pollution


ORG_CITY: TEMPE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative The TRPV1 ion channel protein is important in human physiology and has emerged as a promising drug target for diverse diseases, including many types of pain. This proposed research sets out to better understand the reasons that past TRPV1 drug discovery efforts have been generally unsuccessful and develop tools that will help guide future drug discovery efforts.

PI_NAMEs: VAN HORN, WADE D. (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Adverse event;Agonist;Analgesics;antagonist;aspirate;Binding;Binding Sites;Biometry;biophysical analysis;Biophysics;Body Temperature;cancer type;Capsaicin;Cells;Chemicals;Chili Pepper;Clinical Trials;combat;Computer Analysis;Computer Models;Coupled;Coupling;Data;Dependence;Development;Disease;drug discovery;Drug Targeting;Electrophysiology (science);experimental study;Future;Generations;Goals;Health;Human;human data;human model;Hyperthermia;Individual;interest;Ion Channel;Ion Channel Protein;Length;Ligand Binding;Ligands;mathematical model;Measurement;Membrane;Membrane Proteins;Meta-Analysis;Methodology;Methods;Modeling;Molecular;Molecular Probes;Monitor;Mutagenesis;Nature;new technology;next generation;NMR Spectroscopy;Obesity;Orthologous Gene;Outcome;Pain;pain sensation;patch clamp;pharmacologic;Physiological;Physiology;pre-clinical;Process;Protein Isoforms;Protons;Regulation;Research;Rodent;Role;screening;sensor;Series;single molecule;Spectrum Analysis;Statistical Data Interpretation;statistical learning;Stimulus;Structural Models;Structure;Study models;success;targeted treatment;Techniques;Technology;Temperature;Testing;Therapeutic;Therapeutic Intervention;Thermogenesis;Time;tool;Transmembrane Domain;TRPV1 gene;tumor progression;Vanilloid;voltage

PROJECT_TITLE: Understanding human TRPV1 polymodal activation

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

ORG_STATE: CA

PHR: Project Narrative The goal of this project is to develop an understanding of the detailed mechanisms by which clock proteins from diverse species generate circadian rhythms, used to align physiology and behavior with the day/night cycle for adaptive benefit. Bringing fundamental, molecular insight to the clock will facilitate the development of therapeutics that enhance the systemic synchronization of physiology and behavior to improve human health.

PI_NAMEs: PARTCH, CARRIE L (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Architecture;Behavior;Binding Sites;Biochemical;Biochemistry;Biological;Biological Clocks;biophysical techniques;Cellular biology;circadian;Circadian Rhythms;Clock protein;comparative;Complex;Cues;Cyanobacterium;enzyme activity;flexibility;Funding;Genetic;Goals;Health;Hour;Human;improved;insight;Intervention;Light;Link;Mammals;Molecular;National Institute of General Medical Sciences;pharmacologic;Physiology;Post-Translational Protein Processing;programs;Protein Dynamics;protein function;Proteins;Resources;Signal Transduction;structural biology;Structure;System;therapeutic development;Time

PROJECT_TITLE: Structures and mechanisms of circadian rhythms from cyanobacteria to humans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: Frankfort

ORG_NAME: CONFERENCE OF RADIATION CONTROL PROG DIR

PHR: Project Narrative The objective of this cooperative agreement is to coordinate Federal, State, and Tribal activities to achieve effective solutions to both current and future radiation control challenges. The efforts of volunteers across the nation plus the adoption and implementation of the guidance, recommendations, and procedures provided under this project will provide for improved quality in radiation protection programs throughout the United States. The overall impact of these cooperative efforts will ultimately reduce the risk of illness and deaths associated with unnecessary radiation exposure from all sources and improve the quality of medical radiation imaging and therapy.

PI_NAMEs: MCBURNEY, RUTH EVELYN (contact)

PROGRAM_OFFICER_NAME: MILLER, DONALD

PROJECT_TITLE: Assuring Radiation Protection


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Prevention;Social Determinants of Health;Substance Misuse

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Social inequity has profound influences on the brain and substance use trajectories and vulnerabilities. The pre-clinical studies in this proposal combine models of early life scarcity with paradigms of substance abuse to better understand the cell-type specific changes in the brain that influence vulnerability and resilience to substance use disorders.

PI_NAMEs: BANGASSER, DEBRA A;WIMMER, MATHIEU  (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Accounting;Adult;Adult women;Affect;Affinity Chromatography;Anhedonia;Animal Model;Animals;Beds;Behavior;Behavioral;Behavioral Paradigm;Biological Assay;Brain;Brain region;Cell Nucleus;cell type;Cells;Child;chromatin remodeling;Cleavage Under Targets and Release Using Nuclease;Data;Development;disorder risk;Dissociation;Dose;drug reward;early life adversity;Electrophysiology (science);Environment;Epigenetic Process;epigenetic regulation;Equation;experience;experimental study;Exposure to;Female;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic Transcription;Glutamates;Health;hedonic;Histones;Household;Housing;Human;improved;Individual;Inequity;Intervention;Label;Life;Life Experience;Link;low socioeconomic status;Major Depressive Disorder;male;Measures;Mediating;Mental disorders;Mental Health;Modeling;Molecular;Molecular Profiling;Morphine;motivated behavior;Motivation;N-Methylaspartate;neural;neurochemistry;Neuroglia;neuromechanism;Neurons;novel;Nucleus Accumbens;Opioid;Outcome;outcome disparities;patch clamp;Pathway interactions;Pharmaceutical Preparations;Phenotype;Physiological;Population;postnatal;preclinical study;Prevention;Property;pup;Rat Transgene;Rattus;reinforcer;Reproductive Behavior;resilience;Resource-limited setting;Resources;response;reward processing;Rewards;RNA;Saline;Self Administration;sex;social;social engagement;socioeconomic disparity;Substance abuse problem;substance use;Substance Use Disorder;substance use prevention;substance use treatment;Sucrose;Testing;Therapeutic;Tissues;Training;transcriptome;Translating;Viral;Work

PROJECT_TITLE: Delineating the epigenetic and neural mechanisms by which early life scarcity alters motivated behavior


NIH_SPENDING_CATS: Genetics

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative The mitotic spindle mediates the faithful segregation of DNA to daughter cells. Defects in this process can lead to birth effects and are implicated in cancer. Proposed studies aim to establish how the dynamic properties of the mitotic spindle are controlled and who chromosomes interact with the spindle to insure their faithful inheritance.

PI_NAMEs: BARNES, GEORJANA  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Anaphase;Behavior;Binding;Biochemical;Biological Assay;Birth;cancer prevention;Cell Cycle;Cell Cycle Stage;Cell Nucleus;Cells;chromosome replication;Chromosomes;Complex;Congenital Abnormality;Coupling;Cytoplasm;Cytoskeleton;daughter cell;Defect;Devices;DNA;Fluorescence Microscopy;Genetic;genome integrity;Kinesin;Kinetochores;Laboratories;Lateral;Malignant Neoplasms;Mediating;Microtubules;Mitosis;Mitotic;Mitotic spindle;Molecular Machines;Morphologic artifacts;mutant;Plus End of the Microtubule;preservation;Process;Property;protein complex;Protein Dynamics;Protein Kinase;Proteins;Regulation;Saccharomyces cerevisiae;Saccharomycetales;segregation;Source;Structure;System;Time;Tubulin

PROJECT_TITLE: Saccharomyces cerevisiae microtubule and kinetochore dynamics

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]