PHR: Project Narrative Dissemination and implementation (D&I) science is the study of how to effectively and efficiently spread evidence-based practices and interventions to the people who can benefit from them. It is important to integrate this type of science into the clinical and translational science spectrum because it helps ensure that new treatments and therapies are not just developed, but also effectively implemented and used in real-world settings. This can ultimately lead to improved health outcomes for individuals and communities. This postdoctoral training program will train new scientists in D&I science so we can take better care of people and improve inequities in health and health outcomes.

PI_NAMEs: HIDALGO, BERTHA  (contact)

PROJECT_TITLE: CTSA Postdoctoral T32 at the University of Alabama at Birmingham


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE This research will provide spatial and temporal knowledge on how phosphorylation regulates the function and organization of proteins in the cell, which will allow devising approaches to control cellular functions and phenotypes. This research will also provide mechanistic insight on deleterious protein variants. Collectively, this research will be relevant in combating genetic diseases and diseases where signaling malfunctions, including cancer, metabolic, neurological and infectious diseases.

PI_NAMEs: VILLEN, JUDIT  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Architecture;Biochemistry;Biology;Cell Physiology;Cell Separation;cell type;Cells;Communicable Diseases;Computing Methodologies;design;Disease;frontier;Genetic Diseases;Goals;Histidine;insight;Knowledge;Knowledge acquisition;Malignant Neoplasms;Mass Spectrum Analysis;Metabolic Diseases;Methods;Microscopy;Molecular Biology;Morphology;Mutation;Nervous System Disorder;Organelles;Phenotype;phosphoproteomics;Phosphorylation;protein function;Proteins;Proteome;Proteomics;Regulation;Reproducibility;Research;Role;Signal Transduction;Statistical Methods;Stimulus;translational impact;Tyrosine Phosphorylation;Variant

PROJECT_TITLE: The role of phosphorylation in the cellular organization of the proteome

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: Boston

ORG_DEPT: BIOLOGY

ORG_NAME: TUFTS UNIVERSITY MEDFORD

ORG_STATE: MA

PHR: Project Narrative More than fifty hereditary human diseases are caused by the expansions of simple DNA repeats within individual genes, including such debilitating neurological and neurodegenerative disorders as fragile X syndrome, Huntington’s disease, Friedreich’s ataxia and others. Recently, long-read sequencing revealed massive expansions of simple DNA repeats genome-wide in human cancers. Thus, understanding the unprecedented mechanism responsible for large-scale repeat expansions has broad biomedical implications.

PI_NAMEs: MIRKIN, SERGEI  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Bacteria;Candidate Disease Gene;Cells;Cerebellar Ataxia;Data;DNA;DNA biosynthesis;DNA replication fork;DNA Structure;Endonuclease I;Fragile X Syndrome;Friedreich Ataxia;Genes;Genetic;genome-wide;Genomic Instability;Hereditary Disease;Human;human disease;Huntington Disease;Individual;Inherited;interest;Malignant Neoplasms;Mediating;Methods;Nervous System Disorder;Neurodegenerative Disorders;Neuropathy;nuclease;Okazaki fragments;Plasmids;Recurrence;repaired;Research;Role;Simian virus 40;Somatic Cell;Structure;Syndrome;System;triplex DNA;vestibular system;X-linked dystonia parkinsonism;Yeasts

PROJECT_TITLE: Mechanisms of Genome Instability Mediated by Simple DNA Repeats

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MRAF-C (01)]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE There is an urgent need to improve health care delivery and reduce health care disparities in our geographic region. The Deep South Translational Research Mentored Career Development Program (K12) is a regional partnership of 9 institutions of higher learning (4 academic medical centers), and 2 not-for-profit research organizations. We will train and mentor the next generation of translational researchers and scientists with a primary focus on health outcomes and disparities among diseases disproportionately represented within an area of the southeastern US known as the “Deep South”.

PI_NAMEs: HEFFRON, RENEE A.;MIELE, LUCIO ;SAAG, KENNETH G (contact)

PROGRAM_OFFICER_NAME: ATIENZA, AUDIE A

PROJECT_TERMS: Acceleration;Address;Alabama;Area;base;burden of chronic illness;career;career development;Career Mobility;Clinical;clinical center;Clinical Informatics;clinical practice;Clinical Sciences;clinical translation;cohort;Communities;community engagement;Competence;Deep South;Development;Discipline;disease disparity;dissemination science;drug discovery;Educational Curriculum;Ethnic Origin;experience;Extramural Activities;Fostering;Funding;Future;Gender;Goals;Grant;Growth;Health;health disparity;health equity;implementation science;improved;Individual;Inequity;Infrastructure;innovation;Institution;Knowledge acquisition;matriculation;Mentored Clinical Scientist Development Program;Mentors;Methodology;multidisciplinary;Outcome;peer;poor health outcome;Population;Prevention;Program Development;racial diversity;recruit;Research;Research Personnel;Science;social;Thinking;Training;Training and Infrastructure;training opportunity;Training Programs;Training Support;translational pipeline;Translational Research;translational scientist;Translations;Universities;Update

PROJECT_TITLE: CTSA K12 Program at the University of Alabama at Birmingham

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-6 (01)]


NIH_SPENDING_CATS: Aging;Genetics;Human Genome;Social Determinants of Health

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Adversity experienced during childhood is associated with an increased risk of developing many of the most common diseases of aging in adulthood, such as obesity, cognitive impairment, and cardiovascular disease. This project will address how DNA methylation contributes to the observed relationship between adverse childhood experiences and adult-onset diseases that involve diverse organ systems, by identifying DNA methylation variation associated with early life adversity in a multi-tissue dataset and determining its functional importance through associations with gene regulation. This project will provide insight into how social determinants of health “get under the skin” to contribute to disparities in age-related disease, with the potential to contribute to the future design of intervention strategies.

PI_NAMEs: NORDMAN, JARED  (contact)

PROJECT_TERMS: Adult;adverse childhood events;Affect;Age disparity;age-related disease;aging related disease;Body System;cancer cell;Cardiovascular Diseases;Cell Cycle;Cell division;Cells;Childhood;Data Set;daughter cell;Defect;Development;DNA biosynthesis;DNA Methylation;Drosophila genus;early life adversity;Ensure;experience;flexibility;Future;Gene Expression Regulation;Genetic Materials;Genome;Genome Stability;Genomic Instability;Goals;Impaired cognition;insight;Intervention;Molecular;Mothers;Nuclear Pore;Obesity;Onset of illness;Organism;origin recognition complex;Pore Proteins;Positioning Attribute;Post-Translational Protein Processing;programs;Regulation;Replication Initiation;Risk;S phase;Skin;social health determinants;System;therapy design;Tissues;Variant

PROJECT_TITLE: Developmental control of replication initiation and genome stability

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Aging;Nutrition

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: Project Narrative Ferroptosis is a form of cell death driven by iron-dependent lipid peroxidation. This type of cell death occurs in various human diseases such as neurodegeneration, lung, and kidney disease. Identifying the ways that cells die during ferroptosis will potentially lead to better treatments of these diseases as well as new ways to combat cancer.

PI_NAMEs: WATTS, JENNIFER L (contact)

PROJECT_TERMS: Affect;Aging;Animals;Antioxidants;Biochemical;Caenorhabditis elegans;Cancer cell line;cancer therapy;Cancerous;Cell Death;Cell Death Induction;cell type;Cells;combat;Complex;Development;Diet;dietary;Dietary Component;Disease;experience;flexibility;Genetic;Germ Cells;Germ Lines;human disease;insight;Iron;Kidney Diseases;Linolenic Acids;lipid mediator;lipid metabolism;Lipid Peroxidation;Lung Diseases;Malignant Neoplasms;Metabolism;Mitochondria;Modeling;Molecular;Nature;Nematoda;Nerve Degeneration;novel;Organelles;Pathway interactions;Polyunsaturated Fatty Acids;Regulation;Reproduction;reproductive senescence;Research;Role;Therapeutic;therapeutic target;tool;tumor;Vesicle

PROJECT_TITLE: Molecular mechanisms of ferroptosis induction throughout germline development and aging

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROGRAM NARRATIVE  Building upon our successes over the past four years under U19 AG060917 and its ADRD supplement, we have established a highly collaborative research program based on the benefits of team science that transcends across multiple disciplines, including aging, bone biology, metabolism and neuroscience. The fundamental premise is to determine whether the pituitary hormones FSH and LH, which have been solely linked to fertility, can be targeted to treat three diseases of public health magnitude—osteoporosis, obesity and Alzheimer’s disease—that affect millions of aging women and men worldwide. Towards this, we will use our lead therapeutic antibody, MS-Hu6, genetically–engineered mouse models, and a compendium of cutting– edge technologies to understand the underlying biology of pituitary hormone action on bone, body fat and brain and to advance new therapeutics.

PI_NAMEs: ROSEN, CLIFFORD JAMES;ZAIDI, MONE  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Ablation;Adipocytes;Affect;Aging;aging population;aging related disease;Agonist;Alzheimer's Disease;Alzheimer's disease related dementia;Antibodies;Antibody Formation;Antibody-mediated protection;arm;Biodistribution;Bioinformatics;Biology;Biology of Aging;Biometry;Blocking Antibodies;Body fat;bone;bone cell;Bone Density;bone health;bone loss;Bone remodeling;Brain;brain health;Cells;Chemicals;Clinic;Code;cohort;Collaborations;Data;Data Set;Dementia;design;Deterioration;Diabetes Mellitus;Discipline;Disease;Drug Kinetics;efficacy evaluation;efficacy testing;Elderly woman;Ensure;Epidemiology;Equipment;Estrogens;Evaluation;Evolution;Fatty acid glycerol esters;female fertility;Fertility;Foundations;fracture risk;Genetic;Genetic Epistasis;Genetically Engineered Mouse;Goals;Gonadotropins;good laboratory practice;Health Hazards;Hippocampus;Hormones;Human;human disease;human model;Hypothalamic structure;Impaired cognition;In Vitro;in vivo;Infertility;inhibitor;Investigational New Drug Application;Joints;knock-down;Lead;Leadership;LH Receptors;life span;Link;Magnetic Resonance Imaging;Malignant Neoplasms;Mediating;men;Metabolic;Metabolism;mild cognitive impairment;Modeling;Monkeys;mouse model;Mus;Nature;Nerve Degeneration;neurobehavioral;Neurons;Neurosciences;novel;novel therapeutics;Obesity;old mice;older adult;Osteoblasts;Osteoclasts;Osteocytes;Osteoporosis;Osteoporosis prevention;Ovariectomy;Pathogenesis;Pathway interactions;Perimenopause;Phenotype;Physiology;Pituitary Gonadotropins;Pituitary Hormones;Practice Management;prevent;Productivity;programs;Public Health;Reagent;Regulation;Research;Role;safety study;Sampling;Science;Seminal;Serum;Signal Pathway;Signal Transduction;skeletal;Small Interfering RNA;small molecule;success;synergism;System;Technology;Testing;Therapeutic;Therapeutic antibodies;Thermogenesis;Thinness;Time;Transcend;translational research program;translational study;Translations;Woman

PROJECT_TITLE: FSH - an Aging Hormone?

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (O2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

PI_NAMEs: ZAIDI, MONE  (contact)

PROJECT_TERMS: Adipose tissue;Aging;Agriculture;Area;arm;Biochemistry;Bioinformatics;Biology;Biometry;Blocking Antibodies;Body Composition;bone;Budgets;California;Clinic;Code;Cohort Studies;Collaborations;Collection;Communication;Complex;Data;Data Analyses;Data Set;Dedications;Deposition;Discipline;Doctor of Philosophy;empowerment;Ensure;Epidemiology;epidemiology study;experience;experimental study;Funding;Future;good laboratory practice;Heart;Hormones;Human;Institution;Investigational New Drug Application;Joints;Laboratories;lead candidate;Leadership;Link;Maine;Maintenance;Medical center;medical schools;Metabolism;Methodology;Methods;mouse genetics;Movement;multidisciplinary;Mus;National Institute on Aging;Neurosciences;New York;novel;Personnel Management;Persons;Pharmacology;Physical Chemistry;Practice Management;Principal Investigator;Procedures;programs;Protocols documentation;Publications;quality assurance;Recombinant Follicle Stimulating Hormone;recruit;Regulation;Reproducibility;Research;Research Institute;Resources;Rest;RNA analysis;Running;San Francisco;Schedule;Science;Scientific Advances and Accomplishments;Scientist;Site;Strategic Planning;Structure;Sum;symposium;synergism;System;Technology;Time;transcriptome sequencing;translational medicine;Trust;United States Food and Drug Administration;Universities;Validation;validation studies;virtual;Work

PROJECT_TITLE: Administrative, Biostatistics and GLP Management Core (ABGMC)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition;Obesity;Osteoporosis

PI_NAMEs: LIU, PENG  (contact)

PROJECT_TERMS: Adipose tissue;Aging;Agriculture;Appointment;Atlases;Authorship;Basic Science;Biological Assay;Biomedical Engineering;Blocking Antibodies;Blood specimen;Body Composition;Body fat;bone;Bone Density;Bone Marrow;bone strength;Bone structure;Brain;Brain region;Cell Nucleus;Code;Collaborations;Complement;Connecticut;Data;Data Files;data repository;Data Set;Deposition;Diabetes Mellitus;Doctor of Philosophy;Dual-Energy X-Ray Absorptiometry;Energy Metabolism;Ensure;Enzyme-Linked Immunosorbent Assay;Equipment;Estrogens;experience;Fatty acid glycerol esters;Funding;Genetically Engineered Mouse;Glycoproteins;good laboratory practice;Grant;Histology;Hormone Receptor;Hormones;Immunohistochemistry;Indirect Calorimetry;Injections;Institution;Israel;Laboratories;Lead;Maine;Measurement;Measures;Mechanics;Medical center;medical schools;Metabolic;metabolic phenotype;Metabolism;microCT;mid-career faculty;Mus;Nature;neural tract;neurobehavior;neurobehavioral;neurobehavioral test;Neurohormones;Neurosciences;North Dakota;Nuclear Magnetic Resonance;Obesity;Osmium;Osteoporosis;Paper;Pharmacology;Phenotype;phenotypic data;Physiology;Process;professor;programs;quality assurance;Reagent;receptor expression;Regulation;repository;Reproducibility;Research Institute;Research Personnel;Resources;Rodent;Roentgen Rays;Sampling;Secure;Senior Scientist;Serum;Site;skeletal;Structure;System;Testing;Testosterone;Tissue Sample;Tissues;translational medicine;United States Department of Agriculture;United States National Institutes of Health;Universities;Validation

PROJECT_TITLE: Skeletal, Metabolic and Neurobehavioral Core (SMNC)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Prevention

PI_NAMEs: KIM, SE-MIN  (contact)

PROJECT_TERMS: Acceleration;Adipocytes;Affinity;Aging;Amino Acids;Antibodies;Antibody Formation;Antigens;Binding;Biological Assay;Body fat;bone;bone loss;Bone Marrow;Brain;cell bank;Cell Therapy;Cells;Chromatography;Circular Dichroism;Circular Dichroism Spectroscopy;Clinic;Clinical;Cross Reactions;Differential Scanning Calorimetry;Electrostatics;Endocrinology;Enzyme-Linked Immunosorbent Assay;Epitopes;fast protein liquid chromatography;Fatty acid glycerol esters;Fellowship;first-in-human;flasks;Follicle Stimulating Hormone Receptor;Formulation;Freezing;Funding;Future;G-substrate;Generations;Goals;good laboratory practice;Good Manufacturing Process;Harvest;Hormones;Hour;Human;Human Follicle Stimulating Hormone;Hybridomas;Hydrophobic Interactions;Hydrophobicity;in silico;In Vitro;in vitro Assay;in vivo;in vivo imaging system;Industry Standard;infrared spectroscopy;Korea;Label;Laboratories;Lead;light scattering;manufacture;manufacturing scale-up;Maps;Measures;Medical;Medical center;Medicine;Molecular;Molecular Sieve Chromatography;Monkeys;Mus;Nature;osteoclastogenesis;Osteoclasts;overexpression;Parents;Pharmacology;Phase;polyclonal antibody;Preclinical Testing;prevent;Procedures;professor;Property;protein purification;Proteins;Quality Control;receptor binding;Recombinants;Research;Role;Safety;scale up;Specificity;Spectroscopy, Fourier Transform Infrared;stability testing;Stress;Surface Plasmon Resonance;Temperature;Testing;therapeutic candidate;Training;Transfection;translational medicine;Translational Research;Trastuzumab;Universities;Vaccine Therapy;Validation;Viscosity

PROJECT_TITLE: Antibody Production and Testing Core (APTC)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Estrogen;Genetics;Neurodegenerative;Neurosciences;Nutrition;Obesity;Osteoporosis;Prevention;Women's Health Research

PROJECT_TERMS: 3xTg-AD mouse;Adipose tissue;Admission activity;Affinity;Age;aged;Aging;aging related disease;Alzheimer's Disease;Amino Acids;Amyloid beta-Protein;Antibodies;APP-PS1;Binding;Biochemical;Blocking Antibodies;Body Composition;Body fat;Body Weight;bone;bone cell;bone loss;Bone Marrow;bone mass;Bone remodeling;bone strength;Brain;C57BL/6 Mouse;Cells;Clinical Research;Code;Cognition;cohort;conditioned fear;Cues;Data;Data Set;Diabetes Mellitus;diet-induced obesity;Disease;Doctor of Philosophy;Dual-Energy X-Ray Absorptiometry;Eating;Educational process of instructing;Elderly woman;Epitopes;Estrogens;Evaluation;expectation;experimental study;Fatty acid glycerol esters;Female;Follicle Stimulating Hormone Receptor;Future;Genetic;good laboratory practice;High Fat Diet;Hippocampus;Hormones;Hour;Human;Hypertension;Impaired cognition;Indirect Calorimetry;Injections;Intercept;Investigational New Drug Application;Knock-in;Knock-in Mouse;male;Malignant Neoplasms;Measurement;Measures;memory recognition;Metabolic;metabolic abnormality assessment;Modeling;Monkeys;Monoclonal Antibodies;morris water maze;Mus;mutant;Nature;Nerve Degeneration;Neurons;neuropathology;novel;Obesity;object recognition;old mice;Orchiectomy;Osmium;Osteogenesis;Osteoporosis;Osteoporosis prevention;Ovariectomy;Perimenopause;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;polyclonal antibody;Positioning Attribute;Postmenopause;prevent;Process;Public Health;receptor;Recombinant Follicle Stimulating Hormone;Regulation;Reporting;response;RNA purification;Serum;Signal Transduction;Skeleton;spatial memory;Structure;Symptom Burden;Tamoxifen;Testing;thermostability;Thinness;Tissues;transcriptome sequencing;transcriptomics;Visceral;Wild Type Mouse;Woman

PROJECT_TITLE: Targeting FSH for the Therapy of Osteoporosis, Obesity and Neurodegeneration


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Estrogen;Genetics;Neurodegenerative;Neurosciences;Nutrition;Obesity;Osteoporosis;Women's Health Research

PI_NAMEs: YUEN, TONY  (contact)

PROJECT_TERMS: Ablation;Adipocytes;Adipose tissue;Adrenergic Receptor;Affect;Age;Aging;Alzheimer's Disease;Biological Assay;Blocking Antibodies;Body Composition;Body fat;Body Weight;bone;bone cell;Bone Density;bone loss;bone mass;Bone remodeling;Bone Resorption;bone strength;Brain;Cell Nucleus;Cell Physiology;cell type;Cells;clinical investigation;Clinical Research;Data;dentin matrix protein 1;Diet;Disease;Doctor of Philosophy;Doxycycline;Dual-Energy X-Ray Absorptiometry;efficacy testing;Enterobacteria phage P1 Cre recombinase;Estrogens;experience;experimental study;Fatty acid glycerol esters;Follicle Stimulating Hormone Receptor;Foundations;fracture risk;Funding;Future;Genetic;Goals;High Fat Diet;hindbrain;Hippocampus;Homeostasis;Hormones;Human;Hypothalamic structure;Immunohistochemistry;Impaired cognition;Impairment;in vivo imaging system;Indirect Calorimetry;inducible Cre;Lead;life span;long bone;Malignant neoplasm of prostate;Marrow;Measurement;Mediating;men;Metabolic;metabolic phenotype;Modeling;mouse model;Mus;mutant;Mutant Strains Mice;Nature;neural;Neurocognitive;Neurons;Obesity;older women;Onset of illness;Osmium;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;Osteoporosis;Ovariectomy;Patients;Perimenopause;Peripheral;pharmacologic;Phenotype;Physiological;pre-clinical;preclinical evaluation;prevent;Process;Public Health;raphe nucleus magnus;receptor;receptor expression;Regulation;Reporter;Reporting;Role;Serum;Signal Transduction;Skeleton;Structure;Study of Women's Health Across the Nation;Tamoxifen;Therapeutic;Thinness;Time;transcriptome sequencing;transcriptomics;Transgenic Mice;transmission process;Wild Type Mouse;Woman

PROJECT_TITLE: Deconvoluting the Mechanism of FSH Action on Bone and Body Fat With Aging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Contraception/Reproduction;Dementia;Genetics;Neurodegenerative;Neurosciences;Nutrition;Obesity;Women's Health Research

PI_NAMEs: LIZNEVA, DARIA  (contact)

PROJECT_TERMS: adipocyte differentiation;Adipocytes;Adipose tissue;Adult;Affect;Aging;Agonist;Androgen Receptor;Area;Blocking Antibodies;Body Composition;Body fat;Body Weight;bone;bone loss;Brain;Cell Differentiation process;Cell Nucleus;Cells;Chemicals;Clinical;combinatorial;CREB1 gene;Data;Data Set;Dideoxy Chain Termination DNA Sequencing;Diet;Disease;Doctor of Philosophy;Dose;Doxycycline;Energy Metabolism;Event;Fatty acid glycerol esters;Female;Flutamide;Genes;Genetic Epistasis;Genetic study;Genus Hippocampus;Glycoproteins;Goals;Gonadal Steroid Hormones;Gonadotropins;Heterozygote;High Fat Diet;Homeostasis;hormone receptor-positive;Hormones;Human Chorionic Gonadotropin;Hypothalamic structure;Immunohistochemistry;In Vitro;in vivo;Indirect Calorimetry;Infertility;inhibitor;Investigational New Drug Application;LH Receptors;Ligand Binding;Luteinizing Hormone;Maximum Tolerated Dose;Measurement;Mediating;men;Metabolic;metabolic abnormality assessment;metabolic phenotype;Mitogen-Activated Protein Kinases;Molecular;Mus;mutant;Mutant Strains Mice;Nature;Nerve Degeneration;Neurons;novel;Obesity;older adult;Organoids;Osmium;Ovary;Ovulation;p38 Mitogen Activated Protein Kinase;Pathway interactions;Phenotype;phosphoproteomics;Phosphorylation;Pituitary Gland;Pituitary Hormones;Polycystic Ovary Syndrome;Postmenopause;Prevalence;prevent;Process;Production;Proteins;receptor;Receptor Activation;receptor expression;Recombinant Follicle Stimulating Hormone;Regulation;Reporter;research clinical testing;response;Role;Signal Pathway;Signal Transduction;Small Interfering RNA;small molecule;subcutaneous;synergism;Testosterone;Therapeutic;Thermogenesis;Thinness;Tissues;Transcript;transcriptome sequencing;Treatment Efficacy;Visceral;Weight Gain;Woman;Work

PROJECT_TITLE: Regulation of Body Composition and Energy Metabolism by LH With Aging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Estrogen;Neurodegenerative;Neurosciences;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

PI_NAMEs: SCHAFER, ANNE LOUISE (contact)

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Blocking Antibodies;bone;Bone Density;bone health;bone loss;bone mass;Brain;brain health;Brain Infarction;brain magnetic resonance imaging;brain volume;cerebral atrophy;Clinical;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive testing;cohort;Consensus;Coupling;Data;Dementia;design;Deterioration;Diagnosis;Disease;Estradiol;Estrogen decline;Estrogen Replacement Therapy;Estrogens;evidence based guidelines;executive function;falls;Female;Foundations;Fracture;fracture risk;Funding;Gonadal Steroid Hormones;Health;healthy aging;Hip Fractures;Hip region structure;Hormones;Hospital Records;Human;Impaired cognition;improved;Infarction;information processing;Lead;Life Style;Link;Longitudinal Studies;Magnetic Resonance Imaging;male;Measurement;Measures;Medical;Memory;men;mild cognitive impairment;Monoclonal Antibodies;mortality;Mus;Nature;Neurocognition;neurocognitive test;neuropathology;Obesity;older adult;older men;Older Population;older women;Osteoporosis;Participant;Perimenopause;Persons;Pharmaceutical Preparations;Phenotype;Physical Function;physical impairment;Postmenopause;preclinical study;prevent;Prevention;processing speed;Public Health;research clinical testing;Rodent;Role;sample archive;Sampling;screening;Serum;Sex Hormone-Binding Globulin;Shapes;Skeleton;Testing;Testosterone;Therapeutic;Vertebral column;Vital Statistics;Woman;Women's study

PROJECT_TITLE: Role of FSH in Coupling Dementia and Fracture in the AGES-Reykjavik Cohort of Older Adults


ORG_CITY: RICHMOND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE The sphingolipid metabolites, sphingosine-1-phosphate (S1P) and its precursors sphingosine and ceramides, have emerged as pleiotropic signaling molecules that regulate diverse cellular responses. This proposal on the elucidation of novel roles of sphingolipid metabolites in regulation of membrane contact sites, the areas where membranes from two organelles are found in close apposition, will lead to better understanding of how cellular organelles communicate and integrate their activities.

PI_NAMEs: SPIEGEL, SARAH  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Address;Area;Auditory;Bioenergetics;Biological Process;blood glucose regulation;Cell membrane;Cells;Ceramides;Cholesterol;Cholesterol Homeostasis;Coin;Communication;Enzymes;Family;Goals;Homologous Gene;human disease;Immune System Diseases;infancy;Inflammatory;Link;Location;Lower Organism;Lysosomes;Membrane;Metabolic;Metabolism;Mitochondria;mitochondrial membrane;Movement;Names;Neoplasm Metastasis;novel;Organelles;Organism;Process;Proteins;receptor;Regulation;Research;response;Role;sensor;Signal Transduction;Signaling Molecule;Site;Sphingolipids;Sphingosine;sphingosine 1-phosphate;sphingosine kinase;Stimulus

PROJECT_TITLE: Ins and outs of the bioactive sphingolipid metabolite sphingosine-1-phosphate


ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Narrative Cilia are narrow microtubule-based cell protrusions, which contribute to human health as they possess critical roles in cellular motility and signaling. The assembly of cilia depends on the intraflagellar transport (IFT) motility pathway, which shuttles many ciliary building blocks from the cell body into cilia. This study will investigate how IFT binds to its cargoes and how the transport frequency is regulated; we will also explore alternative, non-IFT routes of protein entry into cilia.

PI_NAMEs: LECHTRECK, KARL  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Adaptor Signaling Protein;Binding;Blindness;Carrier Proteins;cell motility;Cells;Cellular biology;Chlamydomonas;Chlamydomonas reinhardtii;Cilia;Complex;Cytoskeleton;Disease;Ensure;Epilepsy;Epithelium;fluid flow;Frequencies;Functional disorder;Goals;Health;Hormones;Human;Impairment;in vivo imaging;insight;Integral Membrane Protein;interest;Length;Light;Link;Male Infertility;mechanical signal;Mediating;Membrane;Microtubules;Modeling;Molecular Motors;Motility;Motor;Mutate;Mutation;neurodevelopment;novel;Organelles;Orthologous Gene;Pathogenicity;Pathway interactions;Phosphotransferases;Polymers;Process;Protein Biosynthesis;protein transport;Proteins;pulmonary function;Radial;Regulation;restraint;Role;Route;Signal Transduction;Signaling Protein;single molecule;sperm cell;Thinness;Training

PROJECT_TITLE: Regulation of protein transport in cilia


ORG_CITY: Aurora

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Mitochondrial calcium transport proteins regulate important physiological functions, including cell bioenergetics, cytoplasmic calcium signaling, and the initiation of cell death. This project will determine their molecular mechanisms and the mechanisms by which small-molecule compounds modulate their activities. The results will advance our molecular understanding of the physiologically crucial mitochondrial calcium transport process, and can provide key information to facilitate the development of new medicines to treat diseases related to abnormal mitochondrial calcium homeostasis.

PI_NAMEs: TSAI, MING-FENG  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: antiport;Back;Biochemical;Bioenergetics;Biophysics;Calcium;Calcium Signaling;calcium uniporter;Carrier Proteins;Cell Death;Cells;CLC Gene;Complex;Cysteine;Cytoplasm;design;Development;Disease;Electrophysiology (science);Future;Goals;Heart failure;Homeostasis;improved;Inner mitochondrial membrane;innovation;Ion Transport;Kinetics;Knowledge;Liposomes;Mediating;Medicine;member;Methods;Mitochondria;Mitochondrial Matrix;Molecular;Neoplasm Metastasis;Neurodegenerative Disorders;Neurons;novel;novel therapeutic intervention;oxidation;Oxidative Phosphorylation;Pathologic;Pathway interactions;pharmacologic;Physiological;Property;Proteins;reconstitution;Regulation;Reperfusion Injury;Research;Role;Side;Signal Transduction;small molecule;structural biology;System;Testing;tool;Transport Process;Work

PROJECT_TITLE: Molecular mechanisms of the mitochondrial calcium transport system


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Narrative The CTSA Postdoctoral T32 at Indiana University will create and retain a diverse trainee workforce in translational research through training in the science of translation. Through this training our trainees will be able to implement principles of team research and process innovation as key elements in their research program. By utilizing the broad scope of programs available at Indiana University, Purdue University, and the University of Notre Dame we will leverage the trainees' existing skills to further their ability to cross system boundaries through team-based research, as well as provide a thorough exploration of career opportunities available to them in translational research.

PI_NAMEs: HURLEY, THOMAS D. (contact);MCDOWELL, MARY A

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN


NIH_SPENDING_CATS: Cardiovascular;Clinical Research

ORG_CITY: TAMPA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative Severe hypotension and refractory shock are of major importance in critically ill trauma and sepsis patients, but the mechanisms leading to impaired vascular function and vasopressor refractoriness are poorly understood. In this project, we will investigate novel mechanisms by which the functions of key vasopressor receptors are regulated during the cardiovascular stress or “fight-and-flight response”.

PI_NAMEs: MAJETSCHAK, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;Adrenergic Receptor;Angiotensin II Receptor;Animal Model;Animals;Argipressin;Arteries;AVPR1A gene;biological adaptation to stress;blood pressure regulation;Blood Vessels;burden of illness;Cardiovascular system;Catecholamines;chemokine;chemokine receptor;Complex;Critical Illness;Development;Disease;fighting;Functional disorder;G-Protein-Coupled Receptors;Goals;Health;Hemorrhagic Shock;Hormones;Hypertension;Hypotension;Impairment;improved;in vivo;Inflammation;Knowledge;Laboratories;Mediating;Molecular;Molecular Biology Techniques;Molecular Target;Morbidity - disease rate;mortality;Muscle function;novel;novel therapeutic intervention;Patients;Prevalence;Process;programs;Property;receptor;receptor function;Refractory;Regulation;Research;Resistance;response;Risk Factors;Role;septic patients;Shock;Signal Transduction;Smooth Muscle Myocytes;Stress;Trauma patient;Traumatic Hemorrhage;treatment strategy;V1a vasopressin receptor;Vascular Diseases;Vascular Smooth Muscle;Vasoconstrictor Agents

PROJECT_TITLE: Regulation of vascular function after traumatic-hemorrhagic shock and during inflammation

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Project Narrative The goal of this proposal is to elucidate the mechanism of host CD4+ T cell responses, induced by tumor-specific Tc9 cells, in suppressing the growth of relapsed tumors. We will determine 1) the role and importance of Tc9 cell-induced host CD4+ T cell responses in recognizing and eliminating relapsed tumor cells, and 2) the role and mechanism of IL-24-DC circuit in tumors and tumor draining lymph nodes in eliciting tumor-specific CD4+ T cell responses and preventing the recurrence of tumors.

PI_NAMEs: YI, QING  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Transfer;Antigens;antitumor effect;Antitumor Response;cancer immunotherapy;cancer therapy;CD19 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell motility;Cell secretion;Cells;chimeric antigen receptor T cells;Clinical;clinical application;Colon Carcinoma;Contralateral;Cytotoxic T-Lymphocytes;Dendritic Cells;Development;draining lymph node;effector T cell;Future;Gene Family;Goals;GPC3 gene;Granzyme;Growth;Hematologic Neoplasms;Human;IL10 gene;Immune;Immune response;Immunity;Immunologics;Implant;improved;In complete remission;In Vitro;in vivo;Interferon Type II;Interleukin-2;Interleukin-24;Interleukin-9;Knock-out;life span;Malignant Neoplasms;MC38;Mediating;Melanoma;Melanoma patient;member;Mus;neoantigens;neoplastic cell;novel;Ovum;patient prognosis;Patients;Play;polarized cell;prevent;Primary Neoplasm;Recurrence;Recurrent tumor;Relapse;Reporting;response;Role;SILV gene;Solid Neoplasm;success;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Treatment Efficacy;tumor;Tumor Antigens;tumor growth;tumor microenvironment;Tumor stage

PROJECT_TITLE: Tumor-specific CD8+ Tc9 cells activate host CD4+ T cells to control antigen-lost tumors

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Obesity is paradoxically associated with improved survival during sepsis; however, the mechanistic basis for this protection is not understood. This project will investigate alterations in immune cell phenotype, function, and metabolism during sepsis in patients and rodents with underlying obesity.

PI_NAMEs: STARR, MARLENE ELENA (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Admission activity;Cell Physiology;Cells;Cellular Metabolic Process;Clinical Research;Complex;Development;Functional disorder;Goals;Healthcare Systems;Hospitals;Immune;improved;Intensive Care Units;Measures;Mediating;Metabolism;Morbidity - disease rate;mortality;mouse model;novel therapeutics;Obesity;patient population;patient stratification;Patients;Phenotype;Physiological;prevent;programs;Research;Resistance;Rodent;Role;Sampling;Sepsis

PROJECT_TITLE: Obesity-mediated protection in sepsis


PHR: The CTSA Predoctoral T32 at the University of Alabama at Birmingham will support the training and advancement of predoctoral PhD and/or MD students in clinical and translational science and communication across the translational spectrum from basic scientists to clinical scientists to population scientists from 11 institutions across Alabama, Louisiana, and Mississippi. The mission of the Deep South Predoc T32 program is to inspire and develop future clinical and translational scientists by immersing trainees of diverse racial, ethnic, gender, disciplinary, and institutional backgrounds in a novel scheme of team science training and peer mentoring to build communication and leadership skills across the translational spectrum. Our long-term aim is to generate well-equipped clinical and translational scientists who continue to work in diverse teams focused on innovative and creative research in the Deep South, a region that is disproportionately affected by health disparities and inequities.

PI_NAMEs: POLLOCK, JENNIFER S (contact)

PROGRAM_OFFICER_NAME: DIBELLO, ANTHONY THOMAS

PROJECT_TERMS: Alabama;pre-doctoral;Universities


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Protein biosynthesis, also known as translation, is a complex multi-step process essential to every cell and is catalyzed by the ribosome. Building on our solid expertise and previous experience in studying the structure and functions of the bacterial ribosome, the modes of action of ribosome-targeting antibiotics, and mechanisms of drug resistance, our future research will proceed in three main directions: (i) elucidating mechanisms of ribosome stalling; (ii) uncovering molecular mechanisms of context-specific action of ribosomal antibiotics; (iii) providing structural bases of antibiotic resistance. The newly gained knowledge will expand our understanding of fundamental aspects of protein synthesis and uncover the molecular mechanism of action of the most basic as well as the newest antibiotics that, in turn, will aid the future development of antibiotics that inhibit growth and possibly kill pathogenic bacteria more potently than the currently available drugs.

PI_NAMEs: POLIKANOV, YURY  (contact)

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotics;Bacteria;base;Biochemical;Catalytic Domain;Cells;Chemicals;Complex;Cryoelectron Microscopy;Development;Drug resistance;experience;Future;Gene Expression Regulation;Growth;In Vitro;Individual;insight;Knowledge;Ligands;Ligation;Macromolecular Complexes;Mediating;Metabolism;Methods;Microbiological Techniques;Modeling;Molecular;Molecular Mechanisms of Action;Nature;Organism;pathogenic bacteria;Peptides;peptidyl-tRNA;Pharmaceutical Preparations;Play;polypeptide;Preparation;Process;protein aminoacid sequence;Protein Biosynthesis;protein folding;Proteins;Reaction;Resolution;Ribosomes;Role;sensor;small molecule;Solid;Structure;Translations

PROJECT_TITLE: Structural basis for ribosome function and inhibition in bacteria.

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


NIH_SPENDING_CATS: Digestive Diseases

PHR: Project Narrative Cells elicit numerous behaviors to maintain the structure and function of tissues during both normal homeostasis and stress. The proposed study leverages the robustness of the Drosophila intestinal epithelium to investigate the principles underlying complex cell behaviors, which contribute to the maintenance of epithelial structure and function. Thus, the proposed study will promote our knowledge of how to keep epithelia healthy and prevent diseases associated with abnormalities in epithelial homeostasis.

PI_NAMEs: KWON, YOUNG  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TITLE: Complex Cell Behaviors During Epithelial Homeostasis and Stress


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Transmembrane receptors are the major mediators of signaling for cells to communicate with the environment, playing essential roles in many cellular processes. Malfunction of these receptors can cause diseases such as cancer and neurological disorders. The goal of this research program is to understand the structures and mechanisms of these receptors, paving the way for developing targeted therapies for diseases associated with these receptors.

PI_NAMEs: ZHANG, XUEWU  (contact)

PROJECT_TERMS: angiogenesis;Binding;Biochemical;Biological Assay;Biophysics;Blood Platelets;Cardiovascular system;Cell membrane;Cell Physiology;Cells;Characteristics;Communication;Cryoelectron Microscopy;Development;dimer;Disease;Endowment;Environment;Erythrocytes;extracellular;Family;Foundations;Goals;Growth Cones;Hemostatic function;Immune system;Immunity;In Vitro;Individual;KDR gene;Ligand Binding;Ligands;Malignant Neoplasms;Mediator;Membrane;migration;Myocardial Reperfusion Injury;nervous system development;Nervous System Disorder;Neurons;Neuropilins;novel;Platelet Activation;Play;plexin;programs;Proliferating;Property;protein complex;receptor;Receptor Protein-Tyrosine Kinases;Research;response;Role;Semaphorins;Side;Signal Transduction;stoichiometry;Structure;targeted treatment;thromboinflammation;Transmembrane Domain;Vascular Endothelial Growth Factors;vasculogenesis;von Willebrand Factor;Work;wound healing;X-Ray Crystallography

PROJECT_TITLE: Structures and mechanisms of transmembrane receptors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-R (55)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Recently recognized, long-lived, “memory like” natural killer (NK) cells (lymphocytes of the innate immune system which lyse antibody coated virally infected target cells) generate a more vigorous antibody-dependent cell mediated cytotoxicity (ADCC) response compared to their naïve counterparts. The proposed study will lead to development of novel mouse models of ADCC that reflect the situation in humans more accurately. These mouse models can be used for pre-clinical development of monoclonal antibody therapeutics in the public health’s interest for treating cancer and infectious disease.

PI_NAMEs: DAS, JAYAJIT  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Activated Natural Killer Cell;Adaptive Immune System;adaptive immunity;Address;Antibodies;Antibody Response;antibody-dependent cell cytotoxicity;Cancer Patient;cancer therapy;CD32 Antigens;Cells;Chemical Engineering;Communicable Diseases;Communities;Computer Models;CRISPR/Cas technology;Cytomegalovirus;Cytometry;Data;Development;Dimensions;experimental study;FCGR2B gene;FCGR3B gene;gain of function;Gene Modified;Generations;Genes;Genetically Engineered Mouse;Goals;Human;Human Engineering;human subject;Immune response;Immunooncology;Immunotherapy;improved;in silico;Information Theory;Innate Immune System;innovation;interest;Kinetics;laboratory experiment;Lymphocyte;Malignant Neoplasms;Measurement;Mediating;Memory;Modeling;Molecular;Monoclonal Antibodies;mouse model;Murid herpesvirus 1;Mus;Natural Killer Cells;Nonlinear Dynamics;novel;Outcome;phase I trial;Physics;preclinical development;Proteins;Public Health;receptor;reconstruction;response;rituximab;Scheme;Signal Pathway;Signal Transduction;statistics;synergism;T memory cell;Techniques;Therapeutic;Therapeutic Monoclonal Antibodies;Time;time interval;tumor;Viral;Virus Diseases

PROJECT_TITLE: Modeling Antibody-induced Immune Responses by NK cells in Mice and Humans (Resubmission 1)

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Diabetes;Mental Health;Nutrition;Obesity;Prevention

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE This research will compare the effectiveness of a 6-month Mindfulness-based stress reduction (MBSR) intervention compared to health education in improving blood sugar control in patients with uncontrolled type 2 diabetes. If the proposed study finds that MBSR has a beneficial effect on glucose control, it would support the integration of MBSR as an adjunct intervention for improving blood sugar control in type 2 diabetes. Additionally, MBSR could be adapted for other chronic diseases that have also been linked with increased stress and adverse health outcomes.

PI_NAMEs: RAJA-KHAN, NAZIA T. (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Accelerometer;active control group;Address;Adult;Adverse effects;adverse outcome;Affect;alpha-amylase;Amputation;Anxiety Disorders;anxiety symptoms;Behavior;Behavioral;Behavioral Sciences;Biometry;Blindness;Blood Glucose;blood glucose regulation;Caring;Cause of Death;Chronic;Chronic Disease;Clinical;Clinical Psychology;Clinical Trials;clinically significant;compare effectiveness;comparison intervention;Complications of Diabetes Mellitus;Control Groups;coping;Development;diabetes management;Diabetes Mellitus;diabetes risk;diabetes self-management;Diet;Dietary intake;Direct Costs;Distress;Educational Psychology;empowerment;Endocrinology;Exposure to;Facilities and Administrative Costs;fasting glucose;Glucose;Glycosylated hemoglobin A;Guidelines;Health;Health education;High Prevalence;Hour;Hydrocortisone;hypothalamic-pituitary-adrenal axis;improved;Inflammation;Informal Social Control;innovation;International;Intervention;Kidney Failure;Link;Longterm Follow-up;Massachusetts;Measures;Mediating;medication compliance;Mental Depression;Meta-Analysis;mindfulness;mindfulness intervention;mindfulness-based stress reduction;Mission;Myocardial Infarction;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Obesity;Outcome;Overweight;patient population;Patients;perceived stress;Persons;Physical activity;Physiological;Pilot Projects;Prediabetes syndrome;Prevalence;primary outcome;Procedures;programs;Protocols documentation;psychologic;psychosocial;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Reporting;Reproducibility;Research;Research Personnel;Resources;Risk;Risk Reduction;Salivary;Sample Size;secondary outcome;Serum;skills;Stress;stress reactivity;stress reduction;Stroke;Sympathetic Nervous System;systematic review;Telephone;Time;TNF gene;United States;Universities;Video Recording;Woman

PROJECT_TITLE: Randomized Controlled Trial of a Six-Month Mindfulness-Based Intervention for Type 2 Diabetes

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: SUMMARY: This project will define the complete A2A G-protein activation profile at single pathway resolution, investigate A2A signaling in melanoma, and determine if A2A is altered by caffeine. Additionally, it will delineate the anti-melanoma effects of caffeine, providing mechanistic and biomolecular insight to the many epidemiological observations, potentially leading to new therapeutics. This deep mechanistic understanding of A2A signaling in melanoma will also help inform interpretation of ongoing clinical trials with A2A antagonists, and help guide future studies with other GPCRs expressed in melanoma.

PI_NAMEs: BRATHWAITE, RODERICK DION (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Adenosine Triphosphate;Adenylate Cyclase;Affect;Animals;antagonist;anti-PD-1;Apoptosis;Binding Proteins;Bioluminescence;Caffeine;Calcium;Cell Cycle;Cells;Cessation of life;Clinical Trials;Coffee;Consumption;Coupled;CRISPR/Cas technology;Cutaneous Melanoma;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cytoplasm;Data;Differentiated Gene;Disease;Dose;druggable target;Energy Transfer;Engineering;Environmental Exposure;Enzyme-Linked Immunosorbent Assay;epidemiology study;experimental study;Exposure to;Family;Flow Cytometry;Fluorescent Probes;Future;G-Protein Signaling Pathway;G-Protein-Coupled Receptors;G13 Protein;Genetic Transcription;Geography;GTP-Binding Proteins;Human;Immune;Immune response;Immunocompetent;Immunotherapeutic agent;Immunotherapy;improved;In complete remission;In Vitro;in vivo;Incidence;insight;knock-down;Knock-out;Ligands;Mediating;melanocyte;Melanoma;Melanoma Cell;microphthalmia-associated transcription factor;Minority;Modeling;Modernization;mouse model;Mus;novel;novel therapeutic intervention;novel therapeutics;Observational epidemiology;Outcome;overexpression;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phosphorylation;pre-clinical;Predisposition;Proliferating;protein activation;Protein Family;Proteins;Purinergic P1 Receptors;receptor;Receptor Inhibition;Receptor Signaling;Reporter;Resistance;Resolution;response;Response Elements;Risk;Risk Reduction;sex;Signal Pathway;Signal Transduction;Skin;Skin Cancer;Small Interfering RNA;standard of care;System;targeted treatment;Testing;theories;Therapeutic;Tissues;Transgenes;tumor;tumor growth;Ultraviolet Rays;Water;Western Blotting

PROJECT_TITLE: Influence of Caffeine on Melanoma


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Precision Medicine;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This work aims to help improve health outcomes for adults with poorly controlled type 2 diabetes by testing a potentially effective breakfast-focused self-management intervention. We hypothesize that this will be a feasible and effective option.

PI_NAMEs: SASLOW, LAURA  (contact)

PROJECT_TERMS: acceptability and feasibility;Adherence;Adult;adult obesity;American;Amputation;Blood Glucose;Blood Pressure;Body Weight;Calories;Carbohydrates;Cardiovascular Diseases;Clinical Trials;Complex;Consumption;Data;diabetes education;Diabetes Mellitus;Diet;dietary;dietary adherence;Dietary Factors;Dietary Practices;digital;digital health;Disease;Eating;Educational process of instructing;effective intervention;effectiveness trial;efficacy outcomes;emotional eating;feeding;follow-up;glycemic control;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Health;health assessment;health literacy;health related quality of life;Hunger;Hyperglycemia;Hypoglycemic Agents;improved;Individual;Instruction;Insulin;Insulin Resistance;Intake;Intervention;Lipids;literacy;low health literacy;Measures;Mission;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional Study;Outcome;Overweight;Participant;Perception;personalized approach;personalized intervention;personalized nutrition;Pharmaceutical Preparations;Population;Prevalence;programs;Proteins;psychological outcomes;randomized trial;Recommendation;Research;response;Risk;Satiation;satisfaction;Self Efficacy;Self Management;sex;standard of care;Strategic Planning;Testing;treatment strategy;United States National Institutes of Health;Veterans;Work

PROJECT_TITLE: A small steps, low-literacy, breakfast-focused dietary self-management intervention for adults with poorly controlled type 2 diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-C(90)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Aggression is a prevalent social behavior across vertebrate species, yet, it is a costly behavior with potentially deadly consequence and thus needs to be carefully and properly directed. Patients with certain psychiatric illness are at an increased risk of expressing poorly directed and exaggerated aggression and our difficulty in treating these pathological conditions stems from our ignorance of the neural mechanisms that support properly directed aggression under normal conditions. The proposed project is aimed at elucidating the molecular and circuit mechanisms that support directional aggression through fighting-outcome-based social learning.

PI_NAMEs: LIN, DAYU  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Address;Aggressive behavior;Amygdaloid structure;Animals;Behavior;Behavioral;Bipolar Disorder;Brain;Caregivers;Cell Nucleus;Cells;Child;Chronic;Complex;cost;Cues;Data;Development;Dopamine;Dopaminergic Cell;ESR1 gene;experience;experimental study;fighting;Goals;Health;Human;Hypothalamic structure;Image;Individual;insight;Investigation;Learning;Life;Maintenance;male;Maps;Medial;medial preoptic nucleus;member;Mental disorders;Metabolic;Midbrain structure;Middle Hypothalamus;Molecular;Motor;Mus;neural;neural circuit;neuromechanism;Neurons;neuroregulation;new therapeutic target;novel therapeutics;optogenetics;Outcome;Pathologic;Pathway interactions;Patients;Persons;Phase;Play;Post-Traumatic Stress Disorders;Prefrontal Cortex;Preoptic Areas;Process;Psyche structure;Psychological reinforcement;Research;Resources;response;Risk;risk minimization;Robotics;Rodent;Role;Signal Transduction;Site;social;Social Behavior;Social Dominance;social group;Social Hierarchy;social learning;Social status;Spouses;stem;Stress;Synapses;Testing;two-photon;Update;Ventral Tegmental Area;Work

PROJECT_TITLE: Deconstruction of a Neural Circuit for Aggression

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Osteoporosis;Prevention;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Osteoporosis is a disease of aging that leads to ~2 million fractures and ~$17 billion in healthcare costs annually. Based on key preliminary findings, our proposal aims to translate evidence from rodent studies showing that the sympathetic nervous system is an important regulator of bone metabolism to a simple, cost- effective, and safe approach for osteoporosis prevention. Specifically, we will test whether a commonly used cardiovascular drug, atenolol, can prevent bone loss over 2 years in postmenopausal women.

PI_NAMEs: BLACK, DENNIS M;KHOSLA, SUNDEEP  (contact);ROSEN, CLIFFORD JAMES;SHANE, ELIZABETH J

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: Address;Affect;aging related disease;American;antagonist;Atenolol;beta-2 Adrenergic Receptors;Biopsy;bone;Bone Density;bone loss;bone metabolism;Bone necrosis;Bone Resorption;bone turnover;Cardiovascular Agents;Catecholamines;Clinical;Clinical Trials;clinically significant;cortical bone;cost;cost effective;Data;Development;Distal;Dose;Double-Blind Method;Drug usage;Dual-Energy X-Ray Absorptiometry;FDA approved;Femoral Fractures;Femur;Fracture;fracture risk;Health Care Costs;Heart Rate;high risk;Human;human old age (65+);Individual;Intervention;Intervention Studies;Jaw;Knock-out;Label;Left;Measures;Messenger RNA;Metoprolol;Molecular;Mus;Neck;novel;novel strategies;Osteoblasts;Osteogenesis;Osteopenia;Osteoporosis;Osteoporosis prevention;osteoporosis with pathological fracture;patient subsets;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Physicians;Placebo Control;Placebos;Plasma;Play;Population;Population Study;Postmenopausal Osteoporosis;Postmenopause;Premenopause;prevent;Prevention;Propranolol;Radial;radius bone structure;Randomized;Randomized, Controlled Trials;receptor;Resolution;response;Rest;Risk;Rodent;Rodent Model;Role;Safety;Serum;side effect;skeletal;substantia spongiosa;Sympathetic Nervous System;Syndrome;Testing;tibia;Tissues;transcriptome sequencing;Translating;treatment group;trend;Vertebral column;virtual;Woman;X-Ray Computed Tomography

PROJECT_TITLE: Beta1-selective blockade for prevention of postmenopausal bone loss: A randomized controlled trial

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Orthopoxviruses;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: SAN ANTONIO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE As one of the most successful medical interventions in human history, vaccines elicit antibodies to afford immune protection that has eradicated small pox and all but eradicated polio, diphtheria, tetanus, mumps, and measles from the developed world, transforming public health practices in the process. To explore mechanisms underlying anti-viral antibody responses towards development of sophisticated vaccine strategies to deal with recalcitrant infectious agents, here we will analyze the induction of a highly specialized subset of B lymphocytes, i.e., those producing cytokine IL-27 with pleiotropic functions, by vaccinia virus, which was the small pox vaccine and is currently used as vectors of several vaccines (including the HIV vaccine in clinical trial and a recent SARS-CoV-2 vaccine). We will also address the role of IL-27-producing B cells in optimizing protective anti-viral antibody response and underlying mechanisms, including how such B cells to promote the growth and differentiation of antibody-producing B cells, thereby opening a new avenue of research in the vaccine development.

PI_NAMEs: XU, ZHENMING  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;acute infection;Address;Affinity;aluminum sulfate;Antibodies;Antibody Response;Antigens;B cell differentiation;B Cell Proliferation;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Bacterial Infections;Binding;Biological;Cell Differentiation process;cell growth;Cell Shape;Cells;chronic infection;Clinical Trials;COVID-19;COVID-19 vaccine;cytokine;Data;Development;Differentiation and Growth;differentiation in vitro;Diphtheria;Disease;Effector Cell;Elements;Gene Expression;Generations;Genetic Recombination;Genetic Transcription;Haptens;Helper-Inducer T-Lymphocyte;HIV;HIV vaccine;Human;IgG1;IgG3;IL6ST gene;Immune;Immunization;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;Immunologic Receptors;Impairment;In Vitro;in vivo;Infection;Infectious Agent;interleukin-21;Intervention;Knowledge;Ligands;Malaria;Measles;Mediating;Medical;Memory B-Lymphocyte;Modeling;Molecular;Mumps;Mus;Nature;neutralizing antibody;novel;Output;plasma cell differentiation;Plasma Cells;Poliomyelitis;Positioning Attribute;Process;Production;Proliferating;Public Health Practice;receptor;Receptor Signaling;Recording of previous events;Regulation;Reporter;Research;response;Role;Signal Transduction;smallpox eradication;Smallpox Vaccine;Source;Stimulus;Structure of germinal center of lymph node;success;synergism;Testing;Tetanus;TNFSF5 gene;tool;transcription factor;vaccine development;vaccine efficacy;vaccine strategy;Vaccines;Vaccinia virus;vector;Viral;Viral Antibodies;Viral Vaccines;virtual;Virus;Virus Diseases

PROJECT_TITLE: IL-27-producing B cells in the antibody response

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE (Include Public Health Relevance) (Three sentences) Public Health Relevance: Research often leads to ideas that can be translated to new devices, interventions and programs, particularly in aging. Understanding and implementing fundamental human factors principles and practice are critical to effective and successful translation. The Human Factors of Aging Program is designed to meet this need for researchers, clinicians and students who wish to have a positive impact on the lives of older adults through innovation and translation.

PI_NAMEs: REDFERN, MARK S (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Address;Adult;Age;age related;Aging;aging related;Alzheimer's Disease;Anthropometry;Appointment;Articular Range of Motion;Attention;Biomechanics;Biomedical Engineering;Biomedical Research;Capsicum;Cognitive;Collaborations;Communities;Consultations;design;Development;Device Designs;Device or Instrument Development;Devices;dexterity;direct application;Doctor of Philosophy;Education;Educational Curriculum;Educational process of instructing;effective intervention;Engineering;Equilibrium;ergonomics;Evaluation;executive function;experience;Funding;Goals;graduate student;Health Sciences;Hearing;Human;Impaired cognition;improved;Infrastructure;innovation;Interdisciplinary Study;interest;Intervention;Knowledge;Laboratories;laboratory development;Leadership;Medical Device;Medical Device Designs;medical schools;Memory;Movement;multidisciplinary;novel;older adult;Older Population;Otolaryngology;Persons;Physical therapy;Positioning Attribute;Postdoctoral Fellow;Process;professor;programs;Proprioception;prototype;public health relevance;Radiologic Health;rehabilitation science;Research;Research Personnel;sabbatical;Schools;Sensory;Silver;Speed;Students;Time;Translating;Translations;United States National Institutes of Health;Universities;vestibular system;Vision;Work

PROJECT_TITLE: Human Factors of Aging Program

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project narrative: This project will study organizational principles of brain pathways with a combination of chemical tracing and diffusion MRI. The ultimate goal is to assess and improve the accuracy of diffusion MRI, which is currently the only technique for imaging these pathways non-invasively and studying their role in the healthy and diseased brain in vivo. The unique dataset collected by this project will provide a testbed that can aid the neuroimaging research community in identifying shortcomings of current diffusion MRI analysis techniques and provide guidance towards seeking alternative approaches that overcome these shortcomings.

PI_NAMEs: YENDIKI, ANASTASIA  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Acceleration;Address;Algorithmic Analysis;Algorithms;anatomical tracer;Anatomy;Animals;Architecture;Area;automated algorithm;Axon;Brain;Brain Diseases;Brain imaging;brain pathway;Brain region;Brain scan;Chemicals;cingulate cortex;Collaborations;Communities;convolutional neural network;Data;data acquisition;Data Analyses;Data Set;Databases;deep learning;design;Development;Diameter;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Engineering;Error Sources;Exhibits;Fiber;Goals;Histologic;histological stains;Histology;Human;Imaging Techniques;improved;in vivo;Injections;insight;Knowledge;Label;Link;Macaca;Magnetic Resonance Imaging;Maps;Methodology;Methods;Modeling;Monkeys;MRI Scans;multimodality;Myelin;neuroimaging;next generation;nonhuman primate;novel;novel strategies;Outcome;Pathway interactions;Pattern;Performance;Prefrontal Cortex;Process;Property;Protocols documentation;reconstruction;Research;Research Personnel;Resolution;Resources;Role;sample fixation;Sampling;Signal Transduction;Site;Source;Structural Models;Structure;synergism;targeted treatment;Techniques;Therapeutic Intervention;tool;Tracer;tractography;Training;Universities;Validation;Visualization;Work

PROJECT_TITLE: Bridging Diffusion MRI and Chemical Tracing for Validation and Inference of Fiber Architectures

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Osteoporosis

ORG_DEPT: DENTISTRY

PHR: Project Narrative Public Health Relevance: Osteoporosis and low bone mass (osteopenia) are estimated to affect 55 percent of the American population over the age of 50, with nitrogen-containing bisphosphonates (NBPs) among the most accessible and least expensive treatments. Given the “crisis in osteoporosis treatment” and the fear of adverse side effects from treatment with NBPs, including atypical femoral fractures (AFFs) and osteonecrosis of the jaw (ONJ), there is an increasing interest in the identification of molecular factors that may mediate the effects of these drugs. This proposal therefore aims to identify and investigate factors that play a role in these drugs' mechanism of action.

PI_NAMEs: SURFACE, LAUREN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Advisory Committees;Affect;Age;American;Award;Binding;Biological Assay;Biology;bisphosphonate;bone;bone cell;Bone Density;Bone Diseases;bone loss;bone mass;Bone necrosis;career;Cells;Cellular Assay;Charge;CRISPR interference;Cytosol;dosage;drug mechanism;Drug Prescriptions;Endocrine;Endocrinology;Epigenetic Process;Faculty;Femoral Fractures;Fright;Future;Genes;Genetic Screening;Genetic study;Genetic Transcription;genome wide association study;genome wide screen;Goals;Grant;Hospitals;Immersion;Impairment;In Vitro;interest;Investigation;Jaw;Kidney;Knock-out;Knockout Mice;Leadership;Manuscripts;Mediating;member;Mentors;Mentorship;Modeling;Molecular;Molecular Target;mouse model;Mus;NFIC gene;Nitrogen;Osteoclasts;Osteopenia;Osteoporosis;Ovariectomy;Pathway interactions;patient population;patient response;Patients;Persons;Pharmaceutical Preparations;Phase;Physiologic calcification;Physiological;Population;prevent;programs;Protein Biochemistry;Proteins;public health relevance;Publishing;Quality of life;Research;Research Institute;Research Personnel;Resistance;response;Risk;Role;side effect;Skeletal system;skills;standard care;Technical Expertise;tenure track;therapy development;Time;Toxic effect;trafficking;Training;transcription factor;Treatment Efficacy;Treatment Side Effects;treatment strategy;Wild Type Mouse;Work;Writing

PROJECT_TITLE: Deciphering Mechanisms of Nitrogen-Containing Bisphosphonates

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Public Health Relevance Statement Kirrel3 is necessary to form specific types of neural connections called synapses and genetic changes in Kirrel3 are emerging as a risk factor for autism, intellectual disability and, other mental illnesses. Therefore, our research to determine precisely how Kirrel3 regulates synapse form and function is expected to contribute to understanding the fundamental cellular defects underlying brain diseases and, possibly, new ways to treat them.

PI_NAMEs: WILLIAMS, MEGAN ELISE (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Adult;Alternative Splicing;Amino Acids;autism spectrum disorder;Axon;Binding;Biological Assay;Brain;Brain Diseases;Cell Adhesion Molecules;cell type;Cognitive;Complex;conditional knockout;Data;Defect;Dendrites;density;dentate gyrus;Development;Disease;dosage;Electrophysiology (science);Etiology;Exons;experimental study;Filopodia;gamma-Aminobutyric Acid;Genes;Glutamates;Goals;Heterozygote;Hippocampus;Human;Impairment;in vitro Assay;in vivo;insight;Intellectual functioning disability;Knockout Mice;Knowledge;Learning;light microscopy;Location;Mediating;memory process;Mental disorders;Molecular;mossy fiber;Mus;Mutation;neural;Neuroglia;Neurons;novel strategies;Output;Patients;Play;preservation;Process;Property;protein complex;Protein Isoforms;Proteins;Proteomics;public health relevance;recruit;Research;Risk Factors;risk variant;Role;Series;Signal Transduction;Specificity;Structure;Surface;Synapses;synaptic function;synaptic inhibition;synaptogenesis;Tertiary Protein Structure;Testing;trafficking;Variant

PROJECT_TITLE: Molecular mechanisms of target-specific synapse formation

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Antimicrobial Resistance;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: NEW YORK

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Chronic carriers of hepatitis B virus (HBV) are at high risk of developing liver cirrhosis and hepatocellular carcinoma. Our proposed work will explore fundamental aspects of HBV protein translation and genome replication, discover host factors that promote or inhibit HBV infection, and establish a cell culture-based system to inform the development of next-generation HBV antivirals. These efforts will contribute to the ongoing effort to develop new and improved anti-HBV therapies.

PI_NAMEs: RICE, CHARLES M (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Address;Advocate;Affect;anti-hepatitis B;Anti-viral Agents;Anti-viral resistance;antiviral drug development;Attitude;Bacteriophages;Belief;Biological Assay;Biology;Cell Culture System;Cell Culture Techniques;Cessation of life;Chromosomes;Chronic;Chronic Hepatitis B;Chronic Hepatitis C;Circular DNA;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Core Protein;Coupled;Data;Dedications;deep sequencing;detection assay;Development;DNA;DNA Integration;DNA Viruses;drug development;Drug resistance;drug resistance development;drug resistant virus;Exhibits;Fostering;Foundations;Funding;Genetic Transcription;Genome;genome-wide;Genotype;HBV Genotype;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Virus;high risk;Human;improved;In Vitro;in vivo;Individual;Infection;inhibitor;innovation;insight;Integration Host Factors;Knock-out;Knowledge;Life Cycle Stages;Liver;Liver Cirrhosis;Liver Failure;Malignant Neoplasms;Measures;Medical;Methods;Mus;Mutation;new therapeutic target;next generation;novel strategies;nucleoside analog;Nucleotides;Open Reading Frames;optimism;Patients;Persons;Pharmaceutical Preparations;plasmid DNA;Polymerase;Population Heterogeneity;preference;prevent;Primary carcinoma of the liver cells;Proteins;Protocols documentation;Reaction;Replication Initiation;Request for Applications;Research;Research Personnel;Resistance;resistance mutation;Reverse Transcriptase Inhibitors;Reverse Transcription;Risk;RNA;Sampling;Signal Transduction;Strategic Planning;Structure;success;Surface Antigens;System;Technology;Testing;Therapeutic;Therapeutic Intervention;tool;Transcriptional Regulation;Translating;Translational Regulation;Translations;United States National Institutes of Health;vaccine access;Vaccines;Variant;Viral;viral DNA;Viral Drug Resistance;viral fitness;Viral Genome;Viral Proteins;Viral reservoir;Viral Reverse Transcription;viral RNA;Virus;virus core;Virus Diseases;virus host interaction;Virus Inhibitors;Virus Replication;virus testing;Work

PROJECT_TITLE: Launching HBV with RNA to assess antiviral resistance and explore fundamental aspects of virus-host biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-W(02)M]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: NARRATIVE We will combine proteomic, global genomic, molecular, and informatic approaches to provide broad insights into the molecular mechanisms by which liganded nuclear receptors and signals activate enhancers that can constitute a functional connectome. We will elucidate the roles of previously unsuspected enhancer and promoter complexes that participate in the formation of RNP condensates critical for acute enhancer activation network. Finally, we will harness real time imaging of enhancer activation and interactions with subnuclear architectural structures, combined with single molecule imaging to complement our proteomic and genomic approaches to forge new models of acute and chronic enhancer activation strategies.

PI_NAMEs: ROSENFELD, MICHAEL G (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Acute;Address;Amino Acids;Anti-sense RNA;Architecture;Binding;C-terminal;cell type;Cells;Chromosomes;Chronic;Color;combinatorial;Complement;Complex;connectome;Disease;DNA;Enhancers;epigenomics;ESR1 gene;Estradiol;Estrogen Receptors;Estrogens;Event;Exhibits;forging;G22P1 gene;Gene Activation;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genomic approach;Genomics;Goals;Grant;Heterochromatin;Image;imaging approach;Informatics;insight;Investigation;Knowledge;Licensing;Ligand Binding Domain;Ligands;Link;Logic;Mammalian Cell;Mediating;Methods;Modeling;Molecular;molecular imaging;N-terminal;novel;Nuclear Receptors;Outcome;Pattern;Physical condensation;Physiological;Play;Positioning Attribute;programs;promoter;Property;protein complex;Proteins;Proteomics;Reading;real-time images;recruit;Regulation;response;RNA;Role;Series;Shapes;Signal Pathway;Signal Transduction;single molecule;Structure;Time;Topoisomerase;Transcript;transcription factor;Transcriptional Activation;Transcriptional Regulation

PROJECT_TITLE: Enhancer Connectomes in Regulation of Gene Expression

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Genetics;Human Genome;Lung;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Chronic obstructive pulmonary disease (COPD) is a major public health problem that is strongly influenced by cigarette smoking and genetic predisposition. Although previous studies have identified genomic regions associated with COPD, the networks of interacting genes and proteins that influence COPD have not been identified. We will use protein-protein interaction data to build biological networks related to COPD susceptibility, which will provide new insights into the biological mechanisms causing COPD and suggest new pathways for treatment.

PI_NAMEs: SILVERMAN, EDWIN K (contact);WEI, WENYI

PROGRAM_OFFICER_NAME: GAN, WEINIU

PROJECT_TERMS: Address;Affinity Chromatography;Alveolar Macrophages;Biological;Biological Assay;Biological Process;bronchial epithelium;Bronchoscopy;Cell Aging;Cell Death;Cell Death Process;Cell Line;cell type;Cells;Chronic Obstructive Pulmonary Disease;cigarette smoking;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;Complex;CRISPR/Cas technology;Data;Databases;Disease;Disease susceptibility;disorder risk;effective therapy;Epithelial Cells;Excision;experimental study;exposure to cigarette smoke;extracellular;Future;gene interaction;gene network;gene product;Gene Silencing;Genes;Genetic Determinism;Genetic Diseases;Genetic Predisposition to Disease;genome wide association study;genomic locus;Genomic Segment;Human;Inflammation;innovation;insight;interest;Laboratories;Link;Lung;Mass Spectrum Analysis;Methods;Microfibrils;Minority;Modeling;Molecular;Mus;Mutation;Network-based;novel;Pathogenesis;Pathway interactions;Phenotype;protein protein interaction;Proteins;Public Health;Pulmonary Emphysema;Research;Sampling;Structure of parenchyma of lung;Susceptibility Gene;TGFB2 gene;Tissue-Specific Gene Expression;Trans-Omics for Precision Medicine;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;Transforming Growth Factor Beta 2

PROJECT_TITLE: Identifying Protein-Protein Network Interactions between COPD Susceptibility Genes

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative The proposed research is highly relevant to public health in its ability to determine the role of motherhood biographies as a key mechanism in explaining health disparities among midlife women, an understudied population. This proposed research will identify the most health-disadvantaged subpopulations of midlife mothers and nonmothers with attention to differences by 1) motherhood characteristics, 2) educational attainment, 3) race-ethnicity and 4) potential mechanisms (e.g., mother-child relationship). In doing so, this proposal will lead to new evidence-based interventions and public policies designed to improve women's health and reduce health disparities in midlife and beyond, a key goal of NIA. 1

PI_NAMEs: RECZEK, RIN ;THOMEER MCBRIDE, MIEKE BETH (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Address;Adolescence;Adult Children;Age;Aging;Attention;Biography;Birth;Black race;Categories;Characteristics;Child;Cognitive;cohort;Collection;Data;design;Dimensions;Disadvantaged;Education;Ethnic Origin;Evidence based intervention;experience;Family;Fertility expectation;First Births;Generations;Goals;Health;Health behavior;health disparities in women;health disparity;Hispanic;Home;improved;Individual;innovation;insight;late life;Life Cycle Stages;Literature;longitudinal dataset;Longitudinal Studies;Maps;Marital Status;Maternal Health;Mediating;Mediation;Methods;middle age;Midlife women;Minor;Mother-Child Relations;motherhood;Mothers;nonmarital childbearing;Not Hispanic or Latino;Outcome;parity;Pathway interactions;physical conditioning;Population;Pregnancy loss;prospective;Psyche structure;Public Health;Public Policy;Qualifying;Race;Reduce health disparities;Research;Risk Factors;Role;Science;Sequence Analysis;Shapes;social;Techniques;Testing;Variant;Woman;Women's Health;Youth

PROJECT_TITLE: Motherhood Biographies and Midlife Women's Health

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Lung

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Climate change is one of the most important global problems of our time. The consequences for human health are already being felt, and pulmonary morbidity and mortality are increasingly impacted by wildfires, urban and rural air pollution, altered aero-allergen exposures, the repercussions of severe storms and flooding, the changing patterns and severity of pulmonary infections, and other factors. Our goal is to train students and postdoctoral fellows for cutting edge research in the pulmonary impact of climate change and strategies to mitigate the effects.

PI_NAMEs: STOLTZ, DAVID A (contact);THORNE, PETER S

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: climate change;lung health;Training Programs

PROJECT_TITLE: Climate Change and Lung Health Training Program

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE The laboratory mouse remains the most powerful model organism for biomedical research due to its shared mammalian physiology and its well-characterized and accessible genome. Advances in DNA sequencing technologies and tools for genetic engineering mean that the laboratory mouse can now be engineered with unprecedented speed and sophistication; such that now, more than ever, scientists are relying on laboratory mice not only for basic research on disease mechanism but also for direct modeling of human genetic mutations in the context of complex mammalian physiology, gene-by-genome interactions and pre-clinical drug testing. The Mutant Mouse Resource and Research Center at The Jackson Laboratory provides a biorepository for these valuable mouse models for the research community and leadership for best practices in mouse genetics, model development, and research reproducibility.

PI_NAMEs: LUTZ, CATHLEEN M (contact);REINHOLDT, LAURA G

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Acceleration;Agreement;Archives;Basic Science;biobank;Biocompatible Materials;Biomedical Research;California;Caring;Cell Separation;Cloning;Collaborations;Communities;Complex;Cryopreservation;Data;Deposition;Derivation procedure;Development;Disease;disease model;DNA Sequence Alteration;DNA sequencing;drug testing;Embryo;embryo cryopreservation;embryonic stem cell;Engineering;Ensure;Equity;experience;Fee-for-Service Plans;Funding;Gene Targeting;Genes;Genetic;Genetic Engineering;Genetically Engineered Mouse;Genome;Genome engineering;Genotype;Germ;Germ Cells;Goals;gut microbiome;Health;high risk;human model;improved;Informatics;Knock-out;Laboratory mice;Leadership;Maintenance;Marketing;meetings;member;Methods;Missouri;model development;model organism;Modeling;Mouse Embryonic Stem Cells;mouse genetics;mouse model;Mouse Strains;Mus;Mutagenesis;Mutant Strains Mice;Names;new technology;North Carolina;pathogen;Phenotype;Physiology;Policies;pre-clinical;preservation;Procedures;Process;Protocols documentation;Qualifying;Quality Control;Recovery;repository;Reproducibility;Request for Proposals;Research;research and development;Research Personnel;Resources;Scientist;Services;Speed;sperm cell;sperm cryopreservation;System;Technology;Testing;The Jackson Laboratory;tool;Transgenic Organisms;United States;United States National Institutes of Health;Universities;Vision;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C(50)]


NIH_SPENDING_CATS: Genetics

PI_NAMEs: LUTZ, CATHLEEN M (contact)

PROJECT_TERMS: Address;Adoption;Aging;aging population;Agreement;Animals;Archives;Asia;Awareness;Biology;Biomedical Research;Communities;Cryopreservation;Data Analytics;Derivation procedure;design;Development;Disease;disease model;Embryo;Ensure;Environment;ES Cell Line;Europe;experience;Fee-for-Service Plans;Feedback;Foundations;Generations;Genetic;Genetic Engineering;Genetically Engineered Mouse;Genome;genome editing;Genome engineering;Genomics;Genotype;Germ;Goals;Health;Health Status;high risk;human disease;improved;Informatics;interest;International;Laboratories;Laboratory mice;Lead;Mammalian Genetics;Marketing;meetings;member;Methods;Mission;Modeling;Monitor;mouse genetics;Mouse Strains;Mus;mutant;Mutant Strains Mice;pathogen;Patients;Performance;Phenotype;Physiology;Positioning Attribute;Procedures;Process;Production;programs;pup;Qualifying;Quality Control;repository;Reproducibility;Request for Proposals;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Sales;Secure;Selection Criteria;Services;sperm cell;sperm cryopreservation;Standardization;System;Techniques;Technology;Testing;The Jackson Laboratory;Therapeutic;United States National Institutes of Health;web page;web site;Writing

PROJECT_TITLE: Resource Section

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C]


NIH_SPENDING_CATS: Data Science;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: REINHOLDT, LAURA G (contact)

PROJECT_TERMS: Address;Adverse event;adverse outcome;Animal Model;Animal Welfare;Apical;Applied Research;Area;Big Data Methods;biological systems;Cardiac Myocytes;Cell Line;cell type;Chemical Exposure;chemical safety;Communities;Computing Methodologies;Data;Data Analyses;Development;Diet;differentiation in vitro;differentiation protocol;Disease;Distal;Economics;embryonic stem cell;Environment;Evaluation;Event;Evolution;experimental study;Explosion;Funding;gene environment interaction;Genes;Genetic;genetic approach;genetic information;genetic resource;Genetic Services;Germ Lines;Goals;Growth;Health;Heritability;high throughput screening;Housing;Human;In Vitro;in vivo;Inbred Mouse;Inbred Strain;Inbred Strains Mice;Inbreeding;Infection;Infrastructure;interest;Investigation;Laboratories;Laboratory mice;Measurement;Methodology;model organism;Molecular;molecular scale;Mutant Strains Mice;Normal Cell;novel strategies;Pathway interactions;Phenotype;Physiological;Physiology;Pilot Projects;Pluripotent Stem Cells;Population;Property;Protocols documentation;Recombinants;Research;Resources;response;Services;Source;stem cell biology;System;Technology;Testing;The Jackson Laboratory;Toxic effect;Toxicity Tests;Toxicology;Validation;Work

PROJECT_TITLE: Applied Research Section


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: PROJECT NARRATIVE STATEMENT The premise of our proposed study is that adipose tissue T cell miRs play a crucial role in diet-induced obesity by regulating crosstalk between adipocytes, T cells and macrophages. We will test an overall hypothesis that T cell miRs-10a, -125b and -1247 are essential for this regulation. These studies are highly innovative in that they are expected to establish how high fat diet (HFD) regulates miRs, obesity-induced chronic inflammation, T cell homeostatic expansion and macrophage function, which together contribute to many pathophysiological consequences of obesity and may constitute a promising therapeutic strategy for obesity and related metabolic diseases.

PI_NAMEs: SINGH, UDAI P. (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Acceleration;adipocyte differentiation;Adipocytes;adiponectin;Adipose tissue;Affect;American;antagonist;Anti-Inflammatory Agents;Behavioral;Blood Glucose;Body Composition;Body fat;Body Weight;CCL2 gene;Cell Separation;Chronic;Coculture Techniques;Consumption;cytokine;Data;Development;Diet;diet-induced obesity;differential expression;Disproportionately impacts women;Down-Regulation;effector T cell;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;Epidemic;Fasting;Fatty acid glycerol esters;feeding;Flow Cytometry;Genetic;health determinants;High Fat Diet;Human;Immune;Immune response;improved;in vitro testing;in vivo;Inflammation;Inflammatory;inhibitor;innovation;Insulin Resistance;Interleukin-6;Learning;Leptin;Macrophage;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Marker;MicroRNAs;Modeling;mouse model;Mus;Obesity;obesity development;Oligonucleotides;Overweight;Pathogenesis;Pathway interactions;Phenotype;Plasminogen;Play;Population;Prevalence;prevent;Prevention;Production;recruit;Regulation;Regulatory T-Lymphocyte;Reverse Transcriptase Polymerase Chain Reaction;Role;Signal Transduction;Sorting;T cell infiltration;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Time;TNF gene;Transfection;United States;Weaning

PROJECT_TITLE: Adipose T cell microRNAs (miRs) regulate macrophage function during obesity

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Biotechnology;Cachexia;Cardiovascular;Clinical Research;Genetics;Heart Disease;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Cachexia is a syndrome of muscle and fat wasting that causes reduced quality of life, increased caregiver burden and premature death in patients with many chronic conditions, including congestive heart failure. There are over 6 million people in the United States with heart failure and as many as 1 million of these individuals have cachexia, yet the biologic reasons for this horrific complication are completely unknown. The research proposed in this application aims to narrow this knowledge gap by studying the molecular mechanisms of cardiac cachexia in heart failure with the long-term goal of developing new diagnostic and therapeutic strategies for this common and deadly disease complication.

PI_NAMEs: BURKE, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Ablation;Activities of Daily Living;Address;Affect;American;Animal Model;Anorexia;anorexic;Automobile Driving;Biological;Biological Models;Biological Process;Body Composition;Brain;Brain Stem;Cachexia;Calcium;Cancer Cachexia;Cardiac;cardiac cachexia;Cardiac Myocytes;Cardiology;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;Caregiver Burden;Caring;Cell Compartmentation;Cell Cycle;Cell Nucleus;Cessation of life;chemotherapy;Chronic;Chronic Disease;Clinical;Clinical Research;clinically actionable;Complication;Congestive Heart Failure;coronary fibrosis;Coupled;cytokine;Data;Data Set;Development;Dilated Cardiomyopathy;Disease;disease model;Eating;Echocardiography;Event;experimental study;fat wasting;Fatty acid glycerol esters;Fibroblasts;Fibrosis;Foundations;Future;GDF15 gene;Gene Expression;Genes;Genetic;Genetic Models;Goals;Heart;Heart failure;heart function;Heart Transplantation;Histocytochemistry;Hormones;Human;immunoregulation;Individual;Ingestion;innovation;insight;interstitial;Investigation;Knock-out;Knockout Mice;Knowledge;Left;left ventricular assist device;Link;Literature;Macrophage;Malignant Neoplasms;Medical;metabolic phenotype;Metabolism;Methods;Modeling;Molecular;mortality;mortality risk;mouse model;Mus;Muscle;Muscle Cells;Muscular Atrophy;Mutation;Myocardial;Myocardial dysfunction;National Heart, Lung, and Blood Institute;Nerve Growth Factor Receptors;Neuroglia;next generation sequencing;novel;novel diagnostics;novel therapeutic intervention;Organ;overexpression;paracrine;Pathway interactions;Patients;Persons;Phenotype;phospholamban;Pilot Projects;predictive marker;premature;Prevalence;prevent;prognostic;Prognostic Marker;Prospective Studies;Quality of life;receptor;Recombinants;reduced food intake;repository;Research;response;Role;Sampling;Secondary to;Serum;Severity of illness;Signal Pathway;Stress;stressor;Structure;Structure of area postrema;Syndrome;System;Testing;therapeutic target;Tissues;Toxin;transcriptome sequencing;transcriptomics;Transgenic Mice;Transplantation Surgery;Tumor-Derived;United States;Weight;Wild Type Mouse;Work

PROJECT_TITLE: Growth differentiation factor-15 (GDF15) as a novel myocardial hormone in heart failure

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

PHR: PROJECT NARRATIVE According to the NIAAA, in the United States roughly 6% of adults have alcohol use disorder and almost 27% of adults have engaged in binge-drinking in the last month suggesting there is a serious demand for therapies to prevent excessive alcohol consumption. Fibroblast growth factor 21 (FGF21) is a secreted endocrine factor that signals to the brain to decrease alcohol consumption and genetic variation around the loci encoding FGF21 and its receptor, β-klotho, are associated with increased alcohol consumption in humans. Thus, by investigating the mechanism by which FGF21 inhibits alcohol consumption, we aim to discover potential mechanisms driving pathological alcohol consumption while also highlighting potential therapeutic targets.

PI_NAMEs: POTTHOFF, MATTHEW JOSEPH (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acute;Address;Adolescent and Young Adult;Adult;Affect;alcohol abuse therapy;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcoholic Intoxication;Alcohols;Amygdaloid structure;Animal Model;Automobile Driving;Behavior;Behavioral;binge drinking;Biological Assay;Brain;cancer risk;Cardiovascular Diseases;Cells;Central Nervous System;Chronic;Consummatory Behavior;Consumption;Data;designer receptors exclusively activated by designer drugs;Diagnosis;Dissection;Dopamine;Drug usage;Economic Burden;Endocrine;Enterobacteria phage P1 Cre recombinase;Ethanol;Etiology;Feedback;fibroblast growth factor 21;Genes;Genetic Polymorphism;Genetic Variation;genomic locus;Glutamates;Goals;Grant;Health Care Costs;Healthcare;Heavy Drinking;Hormonal;Hormones;Human;improved;in vivo;Individual;innovation;insight;Knock-out;Knockout Mice;Liver;Malignant Neoplasms;Measures;Mediating;mesolimbic system;Metabolic;Metabolic syndrome;Metabolism;Modeling;mouse model;Mus;National Institute on Alcohol Abuse and Alcoholism;neural circuit;Neurons;new therapeutic target;novel;Nucleus Accumbens;Pathologic;Pathway interactions;Peripheral;pharmacologic;Pharmacologic Substance;Physiological;Physiology;Population;preference;Prevalence;prevent;Production;productivity loss;promoter;receptor;Regulation;Rewards;Role;Series;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;Synaptic Transmission;System;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;Time;Tissues;tool;United States;Ventral Tegmental Area;Work

PROJECT_TITLE: Endocrine Regulation of Alcohol Intake

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Pseudouridine is a pre-mRNA modification installed co-transcriptionally by pseudouridine synthases (PUS), which influence splicing regulation. Alternative splicing is important during normal liver function and is rewired in hepatocellular carcinoma (HCC) and expression of multiple disease linked PUSs correlates with poor HCC prognosis. This proposal seeks to elucidate mechanisms of splicing regulation imparted by pseudouridine in HCC cells, which is important for understanding basic cancer biology that could result in new diagnostics, prognostics, and/or therapeutic targets.

PI_NAMEs: MARTINEZ, NICOLE  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 3' Splice Site;Affect;Alternative Splicing;Area;Award;Binding;Binding Sites;Biochemical;Biological Assay;Cancer Biology;cell type;Cells;Cellular Stress;Chromatin;Co-Immunoprecipitations;Coupling;Deposition;Detection;Development;Disease;DNA Polymerase II;Enhancers;Enzymes;epitranscriptome;Event;experimental study;Gene Expression;Gene Expression Regulation;Genes;genetic manipulation;Genetic Transcription;Goals;hepatocellular carcinoma cell line;Hepatocyte;HepG2;Human;human disease;human tissue;In Vitro;in vivo;Individual;Introns;Learning;Link;liver function;Location;Malignant Epithelial Cell;Malignant Neoplasms;Measures;Mediating;Mentors;Messenger RNA;Methods;Modification;Molecular;mRNA Precursor;Normal Cell;novel;novel diagnostics;Nuclear;Nucleic Acid Regulatory Sequences;Nucleotides;Pathogenesis;Pathology;Pathway interactions;Phase;Play;Positioning Attribute;Postdoctoral Fellow;Primary carcinoma of the liver cells;Prognosis;prognostic;Proliferating;promoter;Protein Splicing;Proteins;Pseudouridine;recruit;Regulation;Research;response;RNA;RNA Splicing;RNA-Protein Interaction;Role;Site;skills;spatiotemporal;Techniques;technology development;therapeutic target;Training;transcriptome;Translations;tumor growth;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Role of pseudouridines in pre-mRNA processing