NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Social Determinants of Health;Telehealth;Urologic Diseases;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Dr. Markland is a midcareer physician scientist in the field of geriatrics who has established a federally funded lower urinary tract symptoms/incontinence research program and a record of accomplishment for mentoring early-stage clinical investigators. This midcareer mentoring award will enable Dr. Markland to develop and refine her mentoring skills, continue providing patient-oriented research mentoring to early-stage trainees, and expand her research program in new directions by supporting new patient-oriented research. The proposed projects will build upon an existing mobile health technology platform designed to deliver behaviorally based treatments for lower urinary tract symptoms/incontinence and improve our understanding of factors that impact response to treatments. Mentoring provided should advance the research careers of many early-stage investigators while also improving response to treatments.

PI_NAMEs: MARKLAND, ALAYNE DENISE (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Address;Adherence;Affect;Age;Aging;aging related;Alabama;Anatomy;Award;Behavior;behavior change;Behavior Therapy;Behavioral;Bladder;care providers;care seeking;career;career development;Caring;Cellular Phone;Chronic;clinical care;Clinical Investigator;Clinical Practice Guideline;Clinical Research;Clinical Trials;Collaborations;comorbidity;Data;Dedications;design;Diabetes Mellitus;Diagnosis;Digestive System Disorders;digital health;Education;eHealth;Evaluation;evidence base;Exercise;experience;family support;Female;Friends;Functional disorder;functional status;Funding;Future;Genitourinary system;Geriatrics;Goals;Guidelines;Health;Health behavior;health care settings;Health Services Accessibility;Health Technology;High Prevalence;Hospitals;Hypertension;Improve Access;improved;Incontinence;Increased frequency of micturition;Intake;interest;International;Intervention;intervention effect;Interview;Intestines;intrinsic motivation;Kidney Diseases;Knowledge;Level of Evidence;Liquid substance;lower urinary tract symptoms;Mediating;Mediator;Medical;men;Mental Depression;Mentors;Methodology;mHealth;mhealth interventions;Minority;Modeling;National Institute on Aging;Nocturia;novel;older adult;older men;older women;Outcome Measure;patient expectation;patient oriented research;Patient Outcomes Assessments;Patients;Pelvic Floor Muscle;Pelvic floor structure;Physicians;Postmenopause;Precipitating Factors;Predisposing Factor;Prevention;primary care setting;programs;Psychosocial Factor;psychosocial stressors;Publications;Publishing;Quality of life;Randomized;randomized trial;recruit;remote delivery;Reporting;Research;Research Personnel;research study;response;Risk;Risk Factors;risk sharing;Scientist;Self Efficacy;Severities;Site;skills;Social support;Structure;success;Surveys;symptomatic improvement;Symptoms;Syndrome;systematic review;Technology;technology platform;Testing;Training;treatment arm;treatment response;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Urinary Incontinence;Veterans;video visit;Woman;women's treatment;Work

PROJECT_TITLE: Research and Mentoring Program in Improving Access to Incontinence Care for Older Adults

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Osteoporosis;Prevention

ORG_CITY: SANTA CRUZ

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research will apply a novel dual-layer x-ray detector for calcium scoring to enable early detection and intervention of cardiovascular disease, especially when patients are asymptomatic. Our technology, which innovatively combines material engineering to tune electro-optical properties of chalcogenide alloys, detector structure design, and artificial intelligence-guided image processing, brings much-needed quantitative capabilities to x-ray imaging. This approach will allow accurate quantification of coronary artery calcium from chest x-rays and will have immense impact on proactive healthcare, improving the clinical outcomes of patients, and reducing the number of deaths associated with cardiovascular disease.

PI_NAMEs: ABBASZADEH, SHIVA  (contact);WANG, ADAM S

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Alloys;Arterial Fatty Streak;Arteries;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;automated algorithm;Bone Density;calcification;Calcium;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cessation of life;Charge;Clinical;commercialization;Convection;Coronary Arteriosclerosis;coronary artery calcification;coronary artery calcium;cost;Coupled;Data;Decision Making;density;Descriptor;design;Detection;detection sensitivity;detector;Development;digital;Disease;early detection biomarkers;Early Diagnosis;Early Intervention;electric field;Engineering;Event;experience;Future;Healthcare;Heart;Heart Diseases;heart imaging;heart motion;Image;image guided;image processing;imager;Imaging Techniques;Imaging technology;improved;innovation;Location;Low Dose Radiation;lung cancer screening;machine learning algorithm;Manufacturer;Medical Imaging;Morbidity - disease rate;Morphologic artifacts;mortality;Motion;Motivation;novel;operation;Optics;Osteoporosis;Patient-Focused Outcomes;Patients;Performance;Physics;Population;population based;Predictive Factor;Preventive healthcare;Probability;Property;quantum;Radiation;radiological imaging;Research;Research Personnel;Resolution;Resource-limited setting;respiratory;Roentgen Rays;screening;segmentation algorithm;Selenium;soft tissue;standard of care;Structure;success;System;Technology;Testing;Thermal Conductivity;Thoracic Radiography;Time;Training;Tuberculosis;Vascular blood supply;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: A dual-layer flat panel x-ray detector based on an engineered amorphous chalcogenide alloy for quantifying coronary artery calcium

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative The proposed study is highly relevant to public health because early detection has great potential to reduce cancer burden. Rigorous evaluation of biomarker tests for their clinical utility is imperative for public health.

PI_NAMEs: ETZIONI, RUTH D;FENG, ZIDING ;ZHENG, YINGYE  (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Adherence;anti-cancer research;Biological Markers;biomarker evaluation;biomedical informatics;Biometry;cancer biomarkers;Cancer Burden;Clinical;Collaborations;Collection;Communication;Communities;Community Outreach;Computer Analysis;Computer software;Data;Data Analyses;Data Collection;Data Coordinating Center;data management;Data Management Resources;data quality;Data Science;Data Security;data sharing;data submission;data warehouse;Development;Discipline;Early Detection Research Network;Early Diagnosis;Educational workshop;Ensure;Evaluation;Evaluation Studies;experience;Fred Hutchinson Cancer Research Center;Funding;Image;Informatics;Information Networks;Information Technology;Infrastructure;innovation;Lead;Leadership;Manuals;Manuscripts;meetings;Methodology;Mission;Modeling;Monitor;Multi-Institutional Clinical Trial;Multicenter Studies;network informatics;NIH Grants and Contracts;Observational Study;operation;outreach;Preparation;Procedures;protocol development;Protocols documentation;Public Health;Publishing;quality assurance;Quality Control;Reporting;Research;Research Design;Research Personnel;Resource Informatics;response;sample collection;Scientific Advances and Accomplishments;Scientist;Secure;Services;Software Design;software development;Specific qualifier value;Specimen;statistical service;success;symposium;System;Telephone;Testing;Time;tool;Universities;validation studies;Washington;web site;Women's Health;Work

PROJECT_TITLE: The Early Detection Research Network: Data Management and Coordinating Center


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Infectious Diseases;Malaria;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Rare Diseases;Vector-Borne Diseases;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Although it is clear that placental damage and dysfunction underlie poor birth outcomes associated with maternal malaria infection, the cellular and molecular mechanisms that underlie this damage remain very poorly understood. Exploration of these mechanisms, in particular the role of innate immune cell-driven oxidative stress in mediating placental cell stress and death in malaria, could contribute to the development of improved interventions that would reduce poor birth outcomes in malaria and other pregnancy complications that share these pathogenic features.

PI_NAMEs: MOORE, JULIE M (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Ablation;abortion;Address;Affect;Anti-phospholipid Syndrome;Antioxidants;Automobile Driving;biological adaptation to stress;Biology;Birth;Birth Weight;Blood;Cell Death;cell injury;cell type;Cells;Cellular Stress;Cessation of life;Chemicals;Child;Chronic;Coculture Techniques;Data;Development;Disease;Ensure;Erythrocytes;Etiology;experience;experimental study;Exposure to;fetal;Fetal Growth Retardation;Fetal health;Fetus;Foundations;Functional disorder;Future;hemozoin;High Risk Woman;Histologic;Human;Immune;improved;In Vitro;in vivo;in vivo Model;Infant;Infant Mortality;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Response;inhibitor;International;Intervention;Invaded;Knowledge;Link;Lipid Peroxidation;Malaria;malaria infection;Mediating;Mediator;Modeling;Molecular;Monitor;monocyte;mouse model;Mus;Necrosis;neutrophil;new therapeutic target;Outcome;oxidative damage;Oxidative Stress;Oxygen;Parasites;pathogen;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Peroxidases;Placenta;placental malaria;Plasmodium falciparum;Play;Population;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy disorder;Pregnancy Outcome;Pregnant Women;Premature Birth;preservation;Prevention;Production;Public Health;Reactive Oxygen Species;reproductive;Research;Respiratory Burst;response;Role;Sampling;simulation;Source;stillbirth;Stress;Syncytiotrophoblast;Testing;Tissues;transcriptomics;trophoblast;Villous;Woman;Work

PROJECT_TITLE: Exploring the etiology of oxidative damage and cell death in placental malaria

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: It is proposed to analyze the autoimmune consequences of the bacterial digestion of dietary gluten for development of type 1 diabetes in preclinical models in order to develop new strategies for disease prevention or treatment in at-risk humans.

PI_NAMEs: CHERVONSKY, ALEXANDER V (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: adaptive immune response;Address;Affect;Agonist;Animal Feed;Animal Model;Animals;Antigen Presentation;antigen test;Attention;Autoimmune;Autoimmune Process;Autoimmunity;Beginning of Life;Beta Cell;Caseins;cell type;Cells;Cellular Stress;Cohort Studies;commensal microbes;Communities;cross reactivity;Development;Diet;dietary;Dietary Intervention;dietary manipulation;Digestion;Disease Progression;disorder prevention;Environment;Environmental Risk Factor;Enzymes;experimental study;Flow Cytometry;Food;Generations;genetic manipulation;Genetic Markers;Genetic Predisposition to Disease;Gluten;Gnotobiotic;Goals;gut microbes;host-microbe interactions;Human;human disease;Immune;Immune system;Immune System Diseases;Immunity;In Vitro;in vivo;Ingestion;innate immune mechanisms;Innate Immune Response;Innate Immune System;Insulin;Insulin-Dependent Diabetes Mellitus;interest;Intervention;islet;Knowledge;Laboratories;lymph nodes;Mediating;Microbe;microbial;microbial composition;microbiome;microbiota;microbiota composition;Mus;Nature;Pancreas;Patients;Peptides;Persons;Play;Pre-Clinical Model;Probability;Property;protein biomarkers;Proteolysis;Reducing diet;Regulatory T-Lymphocyte;Research;response;Risk;Role;single cell sequencing;Supplementation;T-Lymphocyte;Technology;Testing;Translating;Uncertainty;Work

PROJECT_TITLE: Enhancement of autoimmunity in type 1 diabetes by gluten

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(02)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARATIVE The main goal of this project is to determine the contribution of human microglia in the establishment of early neural networks during development in healthy and autistic conditions. We will use a human experimental brain organoid model to determine the impact of microglia carrying ASD-related mutations and exposed to environmental risk factors in gene expression, cell populations and network formation.

PI_NAMEs: MUOTRI, ALYSSON R. (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Affect;Appearance;ASD patient;autism spectrum disorder;autistic;Biological Models;Brain;brain cell;cell type;Cells;Central Nervous System;Coculture Techniques;Complex;Data;Development;Disease;Environmental Impact;Environmental Risk Factor;Epigenetic Process;Experimental Models;experimental study;Exposure to;fetal;first responder;Gene Expression;Genes;Genetic;Genetic Predisposition to Disease;Genetic Transcription;genetic variant;Goals;Health;high risk;Human;human induced pluripotent stem cells;Impairment;induced pluripotent stem cell;Invaded;Measures;Methyl-CpG-Binding Protein 2;Microglia;Modeling;Modification;Molecular;mutant;Mutation;Nerve Degeneration;Nervous System Disorder;neural network;neurodevelopment;Neurodevelopmental Disorder;neuron development;Neurons;new therapeutic target;Organoids;Patients;Phagocytosis;Phenotype;Physiological;Physiology;Play;Population;Process;Risk Factors;risk variant;Role;Shapes;single cell ATAC-seq;single-cell RNA sequencing;Synapses;synaptic pruning;synaptogenesis;Testing;Time

PROJECT_TITLE: The Impact of hiPSC-Derived Microglia in Human Brain Development in Health and Disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative The results of this study will provide new mechanistic insights into how bacterial virulence factors inhibit protective immune responses during infection. Completion of the aims will fill important knowledge gaps and inform new therapeutic strategies aimed at augmenting protective immune responses to bacterial pathogens.

PI_NAMEs: BLISKA, JAMES B (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Acetyltransferase;adaptive immunity;Address;Affinity Chromatography;Amino Acids;Binding;Bioinformatics;Biological Assay;CASP1 gene;Cells;combat;cytokine;Data;Defect;Enterobacteria phage P1 Cre recombinase;Evolution;experimental study;extracellular;Family;foot;Genes;Growth;Guanosine Triphosphate Phosphohydrolases;Hepatitis D;Human;IL1B gene;Immune;Immune response;in vivo;Infection;Inflammasome;Innate Immune Response;innovation;insight;Knowledge;Leucine-Rich Repeat;LoxP-flanked allele;Lymphoid Tissue;Macrophage;marenostrin;member;Molecular;monocyte;Mus;Mutagenesis;mutant;Natural Immunity;neutrophil;novel;novel therapeutic intervention;Pasteurella pseudotuberculosis;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Phagocytes;Phosphorylation;Phosphotransferases;prevent;Protein Dephosphorylation;Publishing;Regulation;Research;response;Role;sensor;Serine;Soldier;Spleen;structural biology;Structure;Testing;Two-Hybrid System Techniques;Type III Secretion System Pathway;Variant;Virulence;Virulence Factors;Virulent;Yersinia;Yersinia infections

PROJECT_TITLE: Regulation of host innate and adaptive immunity by bacterial type III effectors

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative This is a renewal application for the T32, Pathophysiology of Human Blood Cells. Now in its 37th year of funding, the training program has continued to grow in the past cycle. The training faculty have outstanding credentials and are highly invested in this program, which has been recognized for its noteworthy achievements in training physician-scientists who have gone on to independent and successful faculty appointments, many in leadership positions.

PI_NAMEs: WILLIAMS, DAVID A (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Blood Cells;Functional disorder;Human

PROJECT_TITLE: Pathophysiology of Human Blood Cells

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Data Science;Depression;Genetics;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Precision Medicine;Prevention;Serious Mental Illness;Social Determinants of Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Leveraging large-scale, readily available electronic health records data from existing routine workflows represents a powerful, untapped opportunity to enhance prevention through the systematic identification of young people at elevated risk of depression. Even a modest improvement in our ability to prospectively stratify risk of adolescent depression at a health systems level could be useful given its prevalence, the current lack of prospective tools that can be implemented at scale, and low burden of potential preventive strategies.

PI_NAMEs: CHOI, KARMEL  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;Algorithms;Area;Award;behavioral health;Big Data;biobank;biomedical informatics;Bipolar Disorder;Body mass index;bridge program;brief prevention intervention;Calibration;career;Caring;Censuses;child depression;Clinical;Clinical Data;Code;Cognitive;cohort;Data;Data Science;Data Set;depression prevention;depressive symptoms;deprivation;design;Detection;Development;Diagnostic;disability;Early Intervention;Electronic Health Record;electronic health record system;Environment;Epidemiology;epidemiology study;Etiology;Event;experience;Foundations;Genetic;genetic epidemiology;Genetic Predisposition to Disease;Genome;genomic data;Genomics;Genotype;Goals;Grant;Guide prevention;health care service utilization;health record;Health system;Healthcare Systems;high dimensionality;high risk;Impairment;improved;Individual;Intervention;K-Series Research Career Programs;Knowledge;Label;Learning;Life;Link;Logistic Regressions;machine learning method;Maps;Measures;Mental Depression;Mental disorders;Mental Health;Mentors;Methods;model building;Modeling;Modernization;Morbidity - disease rate;multidisciplinary;National Institute of Mental Health;Neurotic Disorders;non-genomic;novel;Outcome;Patients;Performance;Persons;Pharmaceutical Preparations;Phenotype;phenotyping algorithm;Population;Positioning Attribute;Predictive Analytics;predictive modeling;Predictive Value;Prevalence;prevent;Prevention;Prevention strategy;Procedures;promote resilience;prospective;Provider;Psychiatric epidemiology;Psychiatric therapeutic procedure;random forest;recurrent depression;Research;Research Personnel;research study;resilience;Resources;Risk;Risk Factors;risk stratification;Sampling;Schizophrenia;Science;Screening procedure;Site;social;social determinants;social genomics;Solid;statistical and machine learning;Stratification;stress related disorder;Structure;substance use;suicidal behavior;support vector machine;Symptoms;Testing;tool;Training;translational research program;United States;unsupervised learning;Validation;Work;World Health

PROJECT_TITLE: Integrating Health Records, Genomic, and Social Data to Stratify Adolescent Depression Risk

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Immersed in the two worlds of clinical practice and research, physician-scientists trained in the fields of health policy, economics and social and behavioral sciences have unique perspectives that are key to effectively addressing the healthcare demands of America’s aging population. Harvard University, home to a long established, nationally recognized MD-PhD program as well as world-renowned graduate programs in Health Policy, Economics, and Social and Behavioral Sciences, is exceptionally well poised to train physician-scientists in these areas. With an existing track record of distinguished alumni and a growing cohort of current trainees, made possible by this NIA institutional training grant, we re-submit this competing renewal so that we may continue to build on these accomplishments.

PI_NAMEs: MCWILLIAMS, JOHN MICHAEL (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Aging;behavioral and social science;Doctor of Philosophy;Training Programs

PROJECT_TITLE: MD-PhD Training Program in Aging and the Social/Behavioral Sciences


NIH_SPENDING_CATS: Biotechnology;Cancer;Obesity;Uterine Cancer;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative: Endometrial cancer (EC) is the sixth leading cause of cancer death among women in the USA and EC is estimated to increase by 1–2% yearly. The obesity epidemic is implicated in the increase of EC cases in the USA. Advanced-stage EC have limited treatment options with poor prognosis and a clear need exists for the identification of actionable drivers as new targets for treating EC. This proposal is clinically significant, as it will establish the significance of LIF/LIFR signaling in EC progression and test the utility of LIFR inhibitor EC359 as a monotherapy or as a combination therapy for treating EC.

PI_NAMEs: VADLAMUDI, RATNA K;VISWANADHAPALLI, SURYAVATHI  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Affinity;Age Years;Anabolism;Apoptosis;Autocrine Communication;bevacizumab;cancer cell;Cancer Etiology;Cancer Patient;cancer recurrence;cancer stem cell;cancer survival;cancer therapy;Cell model;Cessation of life;Chemicals;Chemoresistance;chemotherapy;Chemotherapy and/or radiation;Clear Cell;clinically actionable;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Complement;Complex;CRISPR/Cas technology;cytokine;Data Set;Databases;Death Rate;design;Development;efficacy testing;Endometrial Carcinoma;Estrogens;experience;Family;Fertility;FRAP1 gene;Gene Expression Profiling;Genomic approach;glycoprotein 130;Growth;Gynecologic;high risk;hormone therapy;In Vitro;Incidence;inhibitor;Interleukin-6;Leptin;leukemia inhibitory factor receptor;LIF gene;Malignant Neoplasms;MAP Kinase Gene;member;Metastatic Neoplasm to Lymph Nodes;new therapeutic target;novel therapeutic intervention;Obesity;Obesity Epidemic;older women;Operative Surgical Procedures;Organoids;Pathogenesis;patient derived xenograft model;Patients;Pelvic lymph node group;Postoperative Period;pre-clinical;Production;Prognosis;Progression-Free Survivals;Proto-Oncogene Proteins c-akt;Radiation therapy;rational design;receptor expression;Receptor Signaling;Recurrence;Recurrent disease;response;Risk Factors;Role;SDZ RAD;Serous;Signal Pathway;Signal Transduction;small molecule inhibitor;standard of care;STAT3 gene;stemness;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;therapy resistant;transcriptome;tumor;tumor growth;tumor progression;tumor xenograft;Uterine Corpus Carcinosarcoma;Woman;Women's mortality;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Development  of new therapeutic approaches for endometrial cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Narrative The Gulf South M/U Clinical Trials network brings together the strengths of the two NCORPs of Louisiana. This will double the number of sites offering clinical trials in the Gulf South. We will explore new approaches to increase the participation of minority-underserved patients and community physicians in cancer clinical trials.

PI_NAMEs: OCHOA, AUGUSTO C. (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Address;Agreement;Birds;Bone Marrow Transplantation;Breast;cancer care;Cancer Center;cancer clinical trial;Cancer Control;cancer health disparity;Cancer Patient;Caring;Cervical;clinical center;Clinical Trials;Clinical Trials Network;Communities;Community Health;community organizations;Community Participation;Community Physician;Dedications;Development;Disease;Disparity;experience;Federally Qualified Health Center;Funding;Goals;Health;Health care facility;Health Disparities Research;health disparity;Health Personnel;HIV/AIDS;Hospital Administration;Hospitals;improved;Inequity;Institution;Leadership;Louisiana;Malignant Neoplasms;Minority;Minority Participation;minority patient;multidisciplinary;new technology;novel;novel strategies;oncology program;Outcome;Patient Participation;Patients;Pediatric Oncology;Pilot Projects;Prevention;programs;Provider;referral services;Registries;Research;Research Personnel;Resources;rural area;Rural Community;Screening for cancer;screening program;Site;Testing;treatment disparity;treatment trial;tumor;underserved minority;United States Department of Veterans Affairs;Woman;Women's Health

PROJECT_TITLE: Gulf South Minority/Underserved Clinical Trials Network (Gulf South M/U CTN)


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE Care transitions are a vulnerable period for patients, leading to post-discharge adverse events, falls, medication errors, and readmissions. Specific challenges such as poor communication among inpatient providers, patients, and the primary care team, poor quality and timeliness of discharge documentation, and suboptimal patient understanding of care plans can be improved with our proposed Care Transitions App. In a cluster randomized control trial, we will evaluate the App’s efficacy in engagement of patients and families in their health care and the App’s role in the reduction in adverse events post-discharge.

PI_NAMEs: DYKES, PATRICIA C;SAMAL, LIPIKA  (contact)

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: Care Transitions App for Patients with Multiple Chronic Conditions

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Prostate Cancer;Urologic Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative To date, most genetic risk factors for complex traits are located outside of known genes. This proposal focuses on developing rigorous strategies for identifying the actual causal variants underlying complex traits using novel and powerful methods. Employing these strategies will lead to a more profound understanding of the genetic mechanisms that drive disease risk.

PI_NAMEs: FREEDMAN, MATTHEW L (contact);GIMELBRANT, ALEXANDER ;GUSEV, ALEXANDER

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Acetylation;Affect;Algorithms;Alleles;Allelic Imbalance;ATAC-seq;Automobile Driving;Benign;Binding Sites;Biological Assay;Biology;cancer risk;candidate identification;candidate validation;causal variant;Cell Line;ChIP-seq;Chromatin;chromatin immunoprecipitation;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Communities;Complex;CRISPR/Cas technology;Data;Data Set;Disease;disorder risk;Elements;Enhancers;Epigenetic Process;epigenome;epigenome editing;epigenomics;Evaluation;Gene Expression;Gene Expression Profiling;Generations;Genes;Genetic;Genetic Code;genetic risk factor;Genetic Transcription;genetic variant;Genome;genome editing;genome wide association study;genome-wide;genome-wide analysis;Genotype;Germ Lines;Goals;Heritability;Heterozygote;High-Throughput Nucleotide Sequencing;histone modification;Human;Human Genetics;Hybrids;in vivo;Individual;innovation;large scale data;Libraries;Link;Location;Malignant neoplasm of prostate;Maps;Measurement;Measures;Mediating;Mendelian disorder;Mendelian randomization;Methods;Modeling;Molecular;novel;Open Reading Frames;Pathogenesis;Pathogenicity;Population;Prevention;Prostate;prostate cancer risk;Proteins;Quantitative Trait Loci;Regulatory Element;Risk;risk variant;RNA;Sampling;scale up;Signal Transduction;Site;Specimen;Structure;Susceptibility Gene;Testing;tool;trait;Transcript;transcription factor;transcriptome sequencing;transcriptomics;Transposase;tumor;Untranslated RNA;Validation;Variant

PROJECT_TITLE: Elucidating prostate cancer risk mechanisms through large-scale cistrome wide association studies

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Infectious Diseases;Rare Diseases

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE Staphylococcus aureus is a formidable bacterial pathogen capable of causing a diverse array on infections. One of the most devastating of these is osteomyelitis. The ability of S. aureus to cause these infections is dependent on having its virulence factors available in the right amount at the right time. Regulatory control at the level of the production of these virulence factors is important, but it is not the whole story. The hypothesis behind this application is that an equally important part of this story is the ability of control the production of specific extracellular proteases that modulate the turnover and accumulation of S. aureus virulence factors, and that the staphylococcal accessory regulator (sarA) plays the defining role in this regard. Identifying the most relevant proteases, and defining the manner by which they impact the S. aureus virulence factor repertoire to impact virulence and the host response in bone infection are the overall goals of this application.

PI_NAMEs: SMELTZER, MARK S (contact);TACKETT, ALAN

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Amputation;Animal Model;Antibiotic Therapy;Belief;bone;Bone remodeling;Bone Remodelling Pathway;Clinical;clinically relevant;cytotoxicity;Debridement;Exhibits;experimental study;extracellular;Foundations;Genes;Genus staphylococcus;Goals;Host Defense;Human;Immune response;In Vitro;in vivo;Individual;Infection;Inflammatory Response;Invaded;Laboratories;Mammalian Cell;Mediating;Methicillin;Methicillin Resistance;Microbial Biofilms;Modeling;mutant;Mutation;novel;novel therapeutic intervention;Nutrient;Operative Surgical Procedures;Osteoblasts;Osteoclasts;Osteomyelitis;Pathogenesis;pathogenic bacteria;Peptide Hydrolases;Phenotype;Play;Post-Translational Regulation;Production;prophylactic;Proteins;Proteome;Proteomics;Reporting;Resistance;Role;Sepsis;Staphylococcus aureus;Staphylococcus aureus infection;Surface;Therapeutic;Time;Tissues;Virulence;Virulence Factors

PROJECT_TITLE: Defining the role of post-translational regulation by extracellular proteases in the pathogenesis of Staphylococcus aureus osteomyelitis


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetic Testing;Genetics;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: NARRATIVE The proposed research will provide important insights into the genetic and social/environmental factors that produce optimal brain health by considering the fundamental role that state-level educational contexts play in genetic susceptibility to cognitive impairment and dementia. The proposed research is relevant to several NIA priorities in the area of Alzheimer’s Disease and related dementias (ADRD), including the intersection of genetics and the environment for ADRD risk and identifying early life risk and protective factors for ADRD.

PI_NAMEs: WALSEMANN, KATRINA  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Acceleration;Adolescence;Adult;advanced analytics;African ancestry;Age;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;ancestry analysis;Area;Award;Biological;Black race;brain health;career;Cognition;Cognitive;cognitive function;cohort;Collaborations;college;Data;demented;Dementia;dementia risk;Development;Diagnosis;District of Columbia;Early identification;Education;Educational Status;Environment;Environmental Risk Factor;Episodic memory;Ethnic Origin;European ancestry;experience;Foundations;Funding;Future;Genes;Genetic;Genetic Markers;Genetic Predisposition to Disease;Genetic Risk;Goals;Growth;Health;Health and Retirement Study;Impaired cognition;Impairment;Independent Scientist Award;Individual;innovation;insight;Institution;institutional capacity;International;Knowledge;Length;Life;Life Cycle Stages;Link;Local Government;Maryland;Measurement;Measures;Medicare claim;Memory;Mentors;Methods;model building;Modeling;older adult;Play;Policies;polygenic risk score;Population Study;predictive modeling;Prevalence;programs;prospective;protective factors;Pupil;Race;Research;Research Personnel;Research Priority;Risk;Risk Factors;Role;Sampling;Schools;Scientific Advances and Accomplishments;Scientist;Secure;segregation;Shapes;Short-Term Memory;skills;social;Specific qualifier value;State Government;Subgroup;success;System;teacher;Time;Training;Translating;United States;Universities;Variant;Work

PROJECT_TITLE: The role of early educational contexts in differential genetic susceptibility to cognitive impairment and dementia

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Over half of today’s children are projected to have obesity as adults, putting them at risk of an array of chronic diseases including type 2 diabetes and suggesting the critical need to intervene to prevent obesity and improve nutrition early in childhood. While the Child and Adult Care Food Program is a federal policy mechanism that influences the meals served to millions of young children in the U.S. through child care settings, problems with implementation are weakening the program’s potential to have a substantial impact on child health. The proposed study will use implementation science and economic methodologies to explore determinants of successful CACFP adoption in child care settings and develop an implementation intervention strategy to support child care providers in adopting CACFP so that this federal program can improve young children’s diet quality and reduce food insecurity, thus putting children on a healthier developmental trajectory.

PI_NAMEs: KENNEY, ERICA LAUREN (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: 5 year old;Academy;Address;Adopted;adopted child;Adoption;Adult;Area;Behavior;Carbohydrates;care providers;career;Caring;Child;Child Care;Child Health;Child Nutrition;Child Support;Childhood;Chronic Disease;Communities;community research;Compensation;Consolidated Framework for Implementation Research;cost;Cost Analysis;Data;data integration;Development;Diet;Diet Habits;dietary;Dietary intake;disease disparity;dissemination science;early childhood;economic cost;Economics;Educational workshop;Ensure;Environment;Evaluation;excessive weight gain;Expenditure;Face;Failure;Family;federal policy;feeding;Food;Food Assistance Programs;food environment;food insecurity;food security;Funding;Goals;health disparity;Healthy Eating;healthy weight;Home;implementation barriers;implementation cost;implementation intervention;implementation science;implementation strategy;improved;Institution;Intervention;Interview;Low income;Measures;Medicine;meetings;Mentored Research Scientist Development Award;Mentors;Methodology;Methods;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Nutrition Policy;Obesity;obesity in children;obesity prevention;obesity risk;Parents;Pattern;Physical activity;Policies;Policy Analysis;Policy Developments;Population;population health;prevent;Process;programs;Protocols documentation;Public Health;Public Health Schools;Recommendation;Research;Research Methodology;Research Personnel;Risk;Risk Reduction;Sampling;Science;skills;social epidemiology;societal costs;Structure;success;sugar;Surveys;Time;Training;Translating;United States Department of Agriculture;Update;Vegetables

PROJECT_TITLE: Identifying an implementation strategy to maximize the public health nutrition impact of the Child and Adult Care Food Program

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Conditions Affecting the Embryonic and Fetal Periods;Dietary Supplements;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE We have completed several studies of choline supplementation in children with neurodevelopmental abnormalities resulting from prenatal alcohol exposure (PAE): a feasibility study, a pilot efficacy study, and a long-term follow-up study. The proposed study will continue that work, helping to determine whether choline supplementation during a specific developmental window when the child’s brain remains plastic is able to attenuate the deficits in thinking, memory, processing speed, and behavior that are common in children with PAE and whether these changes are long-lasting. We will also use MRI to measure changes in the trajectory of structures known to be involved in these cognitive functions as well as to examine the development of connectivity in response to choline or placebo.

PI_NAMEs: GEORGIEFF, MICHAEL K.;WOZNIAK, JEFFREY ROBERT (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: 10 year old;5 year old;Acetylcholine;Affect;Age;arm;Attention;Attention deficit hyperactivity disorder;Attenuated;Behavior;Behavior Therapy;behavioral impairment;Brain;Brain imaging;Brain Injuries;catalyst;Cells;Child;Child Behavior;Childhood;Choline;choline supplementation;cholinergic;Clinical;clinical decision-making;clinical implementation;Clinical Trials;Cognition;Cognitive;cognitive benefits;Cognitive deficits;cognitive function;Cognitive Therapy;cohort;Craniofacial Abnormalities;Custom;Data;Delayed Memory;Development;Developmental Delay Disorders;Diagnostic;Dietary Intervention;Diffusion Magnetic Resonance Imaging;Double-Blind Method;Early treatment;efficacy study;Elements;Epigenetic Process;Episodic memory;executive function;Feasibility Studies;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;first-in-human;Follow-Up Studies;Future;Gene Expression;Growth;Hippocampus;Human;Impaired cognition;improved;Individual;Intelligence;Intervention;Interview;Left;long term memory;Long-Term Potentiation;Longitudinal Studies;Longterm Follow-up;Magnetic Resonance Imaging;Maps;Measurable;Measures;Memory;Methods;Methylation;Minnesota;morphometry;Myelin;neurochemistry;Neurocognition;neurodevelopment;neurodevelopmental effect;Neurologic;neuron component;Neurons;Neurotransmitters;non-verbal;novel;Nutrient;Outcome;Parents;Participant;Phase;placebo controlled trial;Placebos;post intervention;postnatal;pre-clinical;Prefrontal Cortex;processing speed;programs;Protocols documentation;Public Health;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Reporting;Research;response;Role;Safety;Series;Short-Term Memory;Structure;Supplementation;Symptoms;System;Testing;Thinking;Time;Translating;treatment duration;treatment effect;United States National Institutes of Health;verbal;Visuospatial;white matter;Work

PROJECT_TITLE: Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Heart Disease;Networking and Information Technology R&D (NITRD);Patient Safety;Primary Health Care

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Heart failure is a common, costly, and morbid condition affecting over 6 million US adults. A number of medications help improve quality of life and lifespan for these patients; yet, only a small percentage of patients are taking these medications at the correct doses. This project will benefit the public health by describing the reasons why patients do not receive these medications and testing a computer-based intervention to help clinicians prescribe these medications to their patients in a pilot study.

PI_NAMEs: AHMAD, FARAZ SHAFIQUE (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Accounting;Active Learning;Adherence;Adoption;Adult;Affect;Area;Award;behavior change;Behavioral;behavioral economics;biomedical informatics;Biometry;Blood Pressure;Cardiology;cardiovascular disorder epidemiology;career;Caring;Characteristics;Clinic;Clinical;clinical decision support;Complex;Computers;cost;Data Analytics;data warehouse;Death Rate;Dedications;design;Development;digital intervention;dissemination science;Dose;Drug Prescriptions;Educational workshop;electronic data;electronic health data;Electronic Health Record;Electronics;Environment;evidence base;evidence based guidelines;Fatigue;feasibility testing;feasibility trial;follow-up;future implementation;Goals;Guidelines;Health;health information technology;Health system;Heart failure;heart failure with reduced ejection fraction;Heart Rate;high risk;Hospitalization;implementation science;improved;improved outcome;individual patient;innovation;insight;Intervention;K-Series Research Career Programs;Knowledge;Lead;life span;Longevity;Measures;Medical;Medicine;Mentors;Mentorship;Methodology;Methods;next generation;older patient;Outcome;Patient Care;Patient Education;patient population;Patient Preferences;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacists;Physicians;Pilot Projects;pilot test;Pragmatic clinical trial;pragmatic trial;Primary Care;primary care clinic;primary care clinician;Process;Productivity;provider behavior;provider factors;Public Health;Quality of Care;Quality of life;Randomized, Controlled Trials;Renal function;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;routine care;Scientist;Site;skills;Social Psychology;success;support tools;symposium;Symptoms;Technology;technology intervention;Testing;Time;Titrations;tool;Training;Training Programs;training project;Treatment Failure;Universities;uptake;usability;Work

PROJECT_TITLE: Electronic Health Record Nudges to Improve Quality of Care in Heart Failure

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

PHR: Project Narrative Hox genes are important regulators of axial patterning and disruption of their function or regulation in mammals can result in transformations of vertebral identity, as well as limb and genital malformations. Our proposed studies utilize exciting new insights into Hox genes in cephalopods to elucidate the basic rules governing the regulation and function of this developmental gene family. Through its focus on a critical transcription factor family regulating axial identity, our project will contribute to our fundamental knowledge of how embryonic patterning is established and will provide insight into the biology of this transcription factor family that plays key roles in human development and disease.

PI_NAMEs: ALBERTIN, CAROLINE B (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Address;Animal Model;Animals;Biological Models;Biology;Body Regions;Cephalopoda;Characteristics;Chromosomes;Complement;Data;Defect;Developmental Gene;Developmental Process;Ear;Elements;Embryo;Embryonic Development;Exhibits;Face;Family;fly;Gene Expression Regulation;Gene Family;genetic manipulation;Genitalia;Genome;genome-wide;Homeobox Genes;Human;Human Development;human disease;insight;Instruction;Invertebrates;Knock-out;Knowledge;Limb structure;malformation;Malignant Neoplasms;Mammals;Nematoda;neural;Octopus;Pattern;Phenotype;Play;programs;Regulation;Resources;spine bone structure;Squid;Structure;tool;transcription factor;transcriptomics;Vertebrates;whole genome;Work

PROJECT_TITLE: A new animal model to elucidate mechanisms of gene regulation and embryonic patterning

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Eye Disease and Disorders of Vision;Physical Injury - Accidents and Adverse Effects

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Sulfur mustard (SM), a vesicant and warfare agent, was recently used by terrorists in Syria. No specific therapy for SM-induced ocular toxicity exists currently. Recently, we developed a novel multimodal non-steroidal topical ophthalmic solution, Turbo Eye Drop (TED), and found it highly potent in counteracting SM-induced blindness and ocular damage in rabbits in vivo. This project establishes the most effective treatment regimen, safety, and mode of action of TED, and leads bench-to-bedside translational development of first potent and safe antidote against SM-induced blindness and ocular injury in vivo.

PI_NAMEs: MOHAN, RAJIV RAVINDRA (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Accidents;Acute;Adverse effects;Affect;Alkylating Agents;Anatomy;Angiogenic Factor;Antidotes;Basement membrane;bench-to-bedside translation;Biological Assay;Blindness;Bulla;Cities;Clinical;Clinical Pathology;Collagen Fibril;Cornea;corneal epithelium;Corneal Injury;Corneal Ulcer;Data;Development;Diagnostic Imaging;diagnostic tool;Dose;Drops;drug development;effective therapy;efficacious treatment;Electron Microscopy;Enzyme-Linked Immunosorbent Assay;Epithelium;Euthanasia;Extracellular Matrix Degradation;Eye;Eye Injuries;Eyedrops;FDA approved;Fibrosis;Fluorescein;Formulation;Frequencies;Functional disorder;Funding;Gases;Generic Drugs;Goals;Grant;Health;high risk;Histologic;Human;Immunofluorescence Immunologic;In Vitro;in vivo;in vivo evaluation;Inflammation;Inflammatory;Inflammatory Response;Intellectual Property;Iran;Iraq;Joints;Kansas;Keratopathy;Lead;Letters;limbal;Literature;Magnetic Resonance Imaging;Measures;Mediating;medical countermeasure;Methods;Microscope;Modeling;Molecular;Monitor;multimodality;Mustard Gas;neovascularization;novel;Ocular Pathology;ophthalmic examination;Ophthalmic Solutions;Ophthalmologist;Organ Culture Techniques;Oryctolagus cuniculus;Pain;Pathology;Pathway interactions;Patients;Penetration;Persons;Pharmaceutical Preparations;Phase;Pilot Projects;pre-Investigational New Drug meeting;Process;Production;Property Rights;Publications;Publishing;Recurrence;Regimen;Research;retinal toxicity;Safety;Schedule;Scientist;Secure;side effect;stem cells;Syria;Techniques;Technology;Temperature;Terrorism;Testing;Therapeutic Effect;therapeutically effective;Time;Tissues;tomography;tonometry;Toxic effect;Transmission Electron Microscopy;Treatment Protocols;vapor;Vesicants;Veterinarians;Vision;War;Western Blotting;World War I

PROJECT_TITLE: Turbo Eye Drops to Treat Ocular Toxicity and Blindness from Sulfur Mustard


NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: This predoctoral training program seeks to prepare the next generation of biomedical researchers with the knowledge, methodologic, analytic and leadership skills to become successful future HIV research investigators. To do this, the program proposes to undertake a two-year program of research training that includes a dual mentored research project, education in specific skillsets, research career development and exposure to the needs of communities at risk so that graduates are prepared to lead future independent HIV/AIDS research programs.

PI_NAMEs: BOSQUE, ALBERTO ;MAGGIRWAR, SANJAY B. (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: comorbidity;HIV;Therapeutic;Training

PROJECT_TITLE: Training in HIV Persistence, Co-morbidities and Therapeutics

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative The need for cardiovascular disease training programs focused on clinical and population research is more compelling than ever. This training program, now in its 14th year, is specifically designed for clinical investigators seeking to apply state-of-the-art clinical and population research methods to important cardiovascular research questions. Such clinical investigators are urgently needed to address important aspects of our nation’s cardiovascular research agenda.

PI_NAMEs: HERRINGTON, DAVID MCLEOD (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: Epidemiology;Training Programs

PROJECT_TITLE: CVD Epidemiology Training Program

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Nutrition;Women's Health Research

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Across cultures, protein-rich foods are widely considered beneficial to postpartum mothers by supplying energy and cellular building materials; however, it remains unknown whether and how dietary amino acids can directly trigger neuromodulatory signaling to facilitate the restorative effects of protein-rich diets. Using Drosophila as a model, this project identifies a neuromodulatory mechanism by which ingested amino acids stimulate the release of a gut-derived peptide hormone to heighten sensitivity to external social cues and restore critical innate behavior. The mechanistic insights expected from this research will shed light on how macronutrients impinge on particular internal physiological states to influence neuronal function and behavior.

PI_NAMEs: SU, CHIH-YING  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TITLE: Genetic analysis of state-dependent chemosensory processing


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Prevention;Substance Misuse

ORG_CITY: Auburn

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

PHR: Project Narrative. This project is relevant to public health because it represents a novel, targeted harm reduction approach to the treatment of Cannabis Use Disorder, a major public health concern in the era of increasing cannabis legalization. This study aims to evaluate the effect of a one-session computerized distress tolerance intervention with just-in-time text message support on distress tolerance, stress-related cannabis use motivation, disordered cannabis use, and psychosocial functioning, representing a highly portable, low-cost solution to the problem of Cannabis Use Disorder.

PI_NAMEs: MACATEE, RICHARD  (contact)

PROGRAM_OFFICER_NAME: SEYMOUR, KAREN ELIZABETH

PROJECT_TERMS: Anxiety;Behavior;Cannabis;cannabis cue;Chronic;Classification;comparative efficacy;computerized;Control Groups;cost;craving;cue reactivity;Cues;Data;depressive symptoms;Devices;disability;Distal;Distress;distress tolerance;Ecological momentary assessment;efficacy evaluation;efficacy testing;emotion regulation;Emotional;emotional distress;Feedback;follow-up;Frequencies;group intervention;habituation;Harm Reduction;Health education;Heterogeneity;high risk;Imagery;improved;Individual;Intervention;intervention cost;intervention effect;intervention refinement;Interviewer;Learning;Link;long term abstinence;Machine Learning;marijuana legalization;marijuana use;marijuana use disorder;marijuana user;Measurement;Measures;Methods;Modification;Motivation;negative affect;neurophysiology;novel;Outcome;Participant;Patient Self-Report;personalized intervention;Pharmaceutical Preparations;Physiological;Physiology;pilot test;Population;portability;Prevalence;psychoeducation;psychosocial;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Reporting;response;Risk Factors;Sampling;secondary outcome;Severities;Shapes;Signal Transduction;Stress;Testing;Text Messaging;texting support;Time;Training;Treatment Efficacy;United States;urinary;Visual;wearable device;Work

PROJECT_TITLE: Refinement and Pilot Testing of a Computerized Distress Tolerance Intervention with Just-In-Time Text Message Reminders for Cannabis Use Disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ED_INST_TYPE: SCHOOLS OF NUTRITION

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Primary Health Care;Social Determinants of Health

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Impact of Medically Tailored Meals on Obesity, Other Health Outcomes, and Healthcare Utilization under Medicaid Flexible Services Project Narrative  This collaboration will evaluate, in the largest study of its kind to date, the impact of medically tailored meals (MTMs) on (a) obesity, diabetes control, and blood pressure, (b) healthcare utilization and healthcare costs, and (c) food security and nutrition security. This research will develop important, timely, high-impact evidence on the potential effectiveness of this innovative intervention to improve health outcomes and reduce utilization in Medicaid patients with medical and social challenges. The results will help scientists, healthcare systems, payers, and policy makers understand the impact of MTMs on obesity, diabetes, and other clinically and policy-relevant outcomes in low-income Americans; compile evidence on the largest MTM intervention in the US to inform future healthcare delivery; and highlight innovations to improve nutrition security and reduce health disparities.

PI_NAMEs: MOZAFFARIAN, DARIUSH  (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: accountable care organization;Admission activity;American;blood glucose regulation;Blood Pressure;Body mass index;Clinic;Clinical;Collaborations;Collection;Communities;Community Healthcare;community organizations;Control Groups;cost;Data;Data Collection;design;diabetes control;Diabetes Mellitus;Diagnosis;Diet;Dietitian;Effectiveness;Emergency department visit;End stage renal failure;Enrollment;Evaluation;flexibility;follow-up;food security;Future;glycemic control;Glycosylated hemoglobin A;Grouping;Health;Health Alliance;Health Care Costs;health care delivery;health care service utilization;Healthcare Systems;Heart failure;high risk;HIV;Home;Hospitals;Household;Housing;improved;Individual;innovation;Inpatients;interest;Intervention;Interview;Kidney Diseases;Low income;Malignant Neoplasms;Massachusetts;Medicaid;Medical;medical schools;member;novel;nutrition;Nutrition Assessment;Nutrition Policy;Nutritional;Nutritional Science;Nutritionist;Obesity;Outcome;Participant;Patient Participation;Patients;Perception;Policies;Policy Maker;programs;Quasi-experiment;Reduce health disparities;Research;Research Personnel;Role;Schools;Scientist;Security;Services;social;State Government;Surveys;Time;Work


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections

PHR: Head and neck squamous cell carcinoma (HNSCC), driven by tobacco and alcohol use as well as HPV infection, is the sixth most common cancer worldwide. This debilitating disease presents a significant health care challenge as cases are rapidly rising in the United States and around the world. The proposed studies will decipher the mechanisms driving immune suppression in HNSCC and will develop new therapeutic approaches that can offer new promise for the successful treatment of this deadly disease.

PI_NAMEs: VARNER, JUDITH A (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Alcohol consumption;antagonist;anti-PD-1;anti-tumor immune response;arginase;Automobile Driving;B-Lymphocytes;Biological Markers;Bone Marrow;Cancer Etiology;CD8-Positive T-Lymphocytes;Cessation of life;Chemotherapy and/or radiation;Circulation;Clinical Trials;Country;cytotoxic;cytotoxic CD8 T cells;Developing Countries;Disease;Disease Outcome;Elements;Funding;Genetic Transcription;Head and Neck Cancer;Head and Neck Neoplasms;Head and Neck Squamous Cell Carcinoma;Healthcare;HPV oropharyngeal cancer;HPV positive;HPV-negative head and neck cancer;Human papilloma virus infection;Immune;Immune checkpoint inhibitor;Immunologic Markers;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;Incidence;Inflammatory;inhibitor therapy;Innate Immune Response;Interleukin-10;Interleukin-12;Macrophage;Malignant Neoplasms;Mediating;men;Molecular;Morbidity - disease rate;mortality;Mus;Myeloid Cells;Natural Killer Cells;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;oral HPV-positive head and neck cancers;Pathway interactions;patient biomarkers;Patient Monitoring;Patient Selection;Patient-Focused Outcomes;Patients;PD-1 inhibitors;Phase;Phase II Clinical Trials;Phenotype;Phosphatidylinositol 4,5-Diphosphate;Phosphotransferases;Play;Proliferating;Protein Isoforms;Proto-Oncogene Protein c-kit;Quality of life;Radiation therapy;recruit;Regimen;Resistance;response biomarker;Role;secondary lymphoid organ;Signal Transduction;Survival Rate;synergism;T cell response;T memory cell;T-Lymphocyte;targeted agent;Testing;Therapeutic;Therapeutic Agents;therapy outcome;Tissues;Tobacco use;tool;trafficking;tumor;tumor eradication;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;United States;Woman

PROJECT_TITLE: Targeting the innate immune response in HNSCC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-S(09)F]


NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative: Failure to resolve inflammatory processes elicits chronic inflammation and disease, which in turn leads to impaired barrier immunity and protection against infections. Bystander activated T cells contribute to pathogen clearance, but have also been identified as critical contributors to perpetuating tissue damage in inflamed tissues. The overall goal of this proposal is to elucidate the mechanisms that negatively regulate bystander activation to determine how tissue homeostasis and barrier immunity can be restored.

PI_NAMEs: PRLIC, MARTIN  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: acute infection;Affect;Agonist;Antigens;Autoimmunity;Biological Models;Blood;CD8-Positive T-Lymphocytes;Cell Separation;Chronic;chronic infection;cytokine;Data;Disease;Dose;effector T cell;Ensure;Equilibrium;Exertion;experimental study;Exposure to;Failure;Goals;Granzyme;Homeostasis;Human;Human Herpesvirus 2;IL18 gene;Immune response;Immunity;Impairment;Infection;Inflammation;Inflammatory;insight;Interferon Type II;Interleukin-12;Interleukin-15;Listeria monocytogenes;LoxP-flanked allele;Malignant Neoplasms;Mediating;Memory;Modeling;mouse model;Mucositis;Mucous Membrane;Nature;novel;pathogen;Pathology;Predisposition;prevent;Process;Property;receptor;Receptor Signaling;receptor-mediated signaling;Resolution;Signal Induction;Signal Transduction;Stimulus;System;T cell response;T cell therapy;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Tamoxifen;Testing;Therapeutic;Time;Tissues;Transforming Growth Factor beta;Viral;virtual;Work

PROJECT_TITLE: Inflammation-driven T Cell Responses and their Dichotomous Effect on Host Immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-E(02)]


NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Deciphering the effect of mutations on the function of normal cellular enzymes is imperative for a better understanding of how cancer and other diseases occur. KRAS, a small enzyme that breaks down the nucleotide guanosine-5'-triphosphatate to guanosine diphosphate, is altered in nearly a third of patients with cancer. The proposed work will identify proteins that physiologically inactivate mutant KRAS and provide fundamental new insight for cancer biology and therapy.

PI_NAMEs: LITO, PIRO  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Alleles;antitumor effect;Applications Grants;Arginine;Binding;Biochemical;Biological Assay;Cancer Biology;cancer cell;Cancer Etiology;cancer therapy;Cell Physiology;Charge;Chromatography;Color;Complex;Cryoelectron Microscopy;Data;Disease;Drug Design;Enhancers;Enzymes;Evaluation;experimental study;Feasibility Studies;Fingers;gain of function;GTP Binding;GTPase-Activating Proteins;Guanosine;Guanosine Diphosphate;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Hydrolysis;inhibitor;innovation;inorganic phosphate;insight;KRAS oncogenesis;KRAS2 gene;Lead;Lung;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Modeling;Molecular Conformation;Monomeric GTP-Binding Proteins;mutant;Mutate;Mutation;Nature;NF1 gene;novel;novel therapeutic intervention;Nucleotides;Oncogenic;Oncoproteins;Outcome;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Physiological;Play;Positioning Attribute;Predisposition;prevent;Property;Proteins;Publishing;Reaction;Reporting;Research;Science;Signal Transduction;small molecule inhibitor;Structure;success;Therapeutic;Therapeutic Effect;Therapeutic Intervention;translational impact;tumor growth;Work;X-Ray Crystallography

PROJECT_TITLE: Dissecting KRAS oncoprotein signaling with small molecule inhibitors

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: The impacts of unmet social needs, such as homelessness, inconsistent access to food, and exposure to violence on health are well-established, especially for cardiovascular disease. A limited but growing body of evidence suggests that screening for and addressing these needs – also referred as social determinants of health -- in clinic settings helps to connect patients to resources to address unmet needs and has the potential to improve health outcomes. Veterans carry a high burden of unmet needs. At present, VA systematically screens for only two unmet needs; homelessness and food insecurity. We propose to assess the efficacy of systematically screening Veterans for eight unmet needs (i.e., housing, food insecurity, utility insecurity, transportation, legal problems, employment, safety, and social isolation), and compare the effect of referral mechanisms of varying intensity on Veterans’ connection to resources, reduction of unmet needs, treatment adherence, reduced preventable hospitalizations, and clinical outcomes.

PI_NAMEs: GUREWICH, DEBORAH  (contact)

PROJECT_TERMS: Address;Adherence;Affect;Ambulatory Care;American Heart Association;Appointment;arm;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;care coordination;Caring;Cessation of life;Characteristics;Clinic;Clinical;Communities;compare effectiveness;Comprehensive Health Care;Data;disability;Disease Outcome;disparity reduction;Distal;efficacy evaluation;Emotional;Employment;Ensure;evidence base;follow-up;Food;food insecurity;Funding;Future;glycemic control;Goals;Health;Health behavior;health care service utilization;health equity;Health Policy;Health Priorities;Health Resources;High Prevalence;Homelessness;Hospitalization;Housing;Human Resources;improved;improved outcome;Individual;innovation;Inpatients;Intervention;Intervention Studies;Interview;Investments;Legal;Link;Medical;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;Outcome;Patient-Centered Care;Patients;personalized care;Persons;Pharmaceutical Preparations;Phase;Policy Maker;population health;post intervention;Prevalence;Primary Care;primary outcome;Process;programs;Randomized;Randomized, Controlled Trials;Recommendation;Research;Resources;response;Rest;Risk Factors;Safety;screening;screening guidelines;secondary outcome;Services;Shapes;Site;social;social determinants;social health determinants;Social isolation;Social Well-Being;Social Work;Social Workers;sociodemographics;stakeholder perspectives;success;System;Testing;tool;Transportation;treatment adherence;urgent care;Veterans;violence exposure;Work

PROJECT_TITLE: The Effect of Screening and Referral for Social Determinants of Health on Veterans'  Outcomes

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Pre-exposure prophylaxis (PrEP) is a medication that can greatly reduce the risk of acquiring HIV infection; however, PrEP’s effectiveness is reduced by poor adherence. We developed a mobile game that improved adherence to PrEP. In this proposed project, we will further test the game with a larger number of people, and the individual, organizational and structural factors associated with the implementation of the gaming app will be collected through in-depth interviews with patients, staff, and clinic administrators.

PI_NAMEs: BROCK, JAMES BENJAMIN;WHITELEY, LAURA B (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: absorption;Adherence;Administrator;African American;Age;Age Years;AIDS prevention;Anti-Retroviral Agents;behavior measurement;Behavioral;Biological;Black race;Blood;Boston;Caring;Clinic;Clinical;clinical research site;combat;community advisory board;comparative efficacy;comparison control;Control Groups;Data;Development;Diphosphates;Dissemination and Implementation;Dose;Dryness;Effectiveness;effectiveness-implementation RCT;efficacy testing;Evaluation;experience;Face;follow-up;formative assessment;Future;future implementation;Geography;group intervention;Hair;Health Benefit;Health Personnel;Health Promotion;Health Services;Hispanic;HIV Infections;HIV risk;Hybrids;implementation context;implementation intervention;improved;Individual;innovation;Intervention;intervention delivery;Interview;Knowledge;Latinx;Measures;Mediator;member;men who have sex with men;Mississippi;Modeling;Motivation;New England;Participant;patient population;Patient Self-Report;Patients;Perception;Persons;Pharmaceutical Preparations;Phase;Population;Population Heterogeneity;pre-exposure prophylaxis;Prevention strategy;Promoting Action on Research Implementation in Health Services framework;randomized trial;Randomized, Controlled Trials;Records;Research;Risk;Risk Reduction;Self Efficacy;Site;skills;social stigma;Spottings;structural determinants;success;Tenofovir;Testing;Treatment Efficacy;Viral;virus testing

PROJECT_TITLE: A Multisite Randomized Trial of Viral Combat:  A Mobile Gaming App to Improve Adherence to PrEP

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Narrative The pipeline of new antimalarial drugs is promising but the specter of drug resistance is always looming. Hence, we are proposing to develop novel chemotypes against PfATP4 a proven drug target. In this study, we will carry out lead optimization studies for two series of molecules developed in our laboratory and test them in an in vivo model of P. falciparum infection and assess resistance development.

PI_NAMEs: KORTAGERE, SANDHYA ;VAIDYA, AKHIL B (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Advocate;Ally;Anti-malarials;Artemisinins;ATP phosphohydrolase;benzimidazole;Biology;chemical synthesis;Chemicals;clinical investigation;Clinical Trials;Collaborations;Data;Development;Dose;drug development;Drug Kinetics;Drug resistance;Drug Targeting;Ensure;Failure;first-in-human;Future;Genetic;genotoxicity;Goals;Half-Life;Homeostasis;Human;humanized mouse;improved;in vivo;in vivo Model;India;Infection;inhibitor;Injectable;International;Laboratories;Lead;lead optimization;Malaria;Medicine;Metabolic;meter;mouse model;Na(+)-K(+)-Exchanging ATPase;Names;novel;Parasite resistance;Parasites;pathogen;Patient Compliance;Pharmaceutical Chemistry;pharmacokinetics and pharmacodynamics;Pharmacology;Phase II Clinical Trials;Plasmodium falciparum;Plasmodium vivax;Population;pre-clinical;Property;Pyrazoles;Recording of previous events;Research Personnel;Resistance;Resistance development;Safety;safety study;scaffold;Series;Services;simulation;small molecule;Solubility;Testing;Treatment Failure;Work

PROJECT_TITLE: Advancing Fast-acting Antimalarials that Disrupt Na+ Homeostasis in Parasites

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE The endogenous APOBEC3 enzymes are proposed to cause a large number of mutations found in many different cancer types. Using newly discovered human cancer cell line models, we will determine the causes and consequences of APOBEC3 mutagenesis in cancer with the goals of determining if APOBEC3- mutagenesis represents a disease modifying process that can be therapeutically exploited at different stages of cancer evolution and identifying specific enzymes as putative targets for therapeutic pursuit.

PI_NAMEs: MACIEJOWSKI, JOHN  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Address;B-Cell Lymphomas;Bioinformatics;Biological Assay;Biological Markers;Biological Models;biomarker validation;Breast Cancer cell line;cancer cell;Cancer cell line;Cancer Etiology;cancer genome;Cancer Model;cancer prevention;cancer therapy;cancer type;carcinogenesis;Cell Line;Cell model;Cells;Characteristics;Clinical;Cytidine;Cytosine deaminase;Data;Deaminase;Detection;Dimensions;Disease;Engineering;Enzymes;Etiology;Evolution;experimental study;Exposure to;Family;Gene Mutation;Genome;genome sequencing;Goals;High Prevalence;Human;human disease;Immune;imprint;Individual;insight;Knock-out;Link;Lung Adenocarcinoma;lung cancer cell;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;member;Metastatic Carcinoma;Modeling;Molecular;Monitor;Mus;Mutagenesis;mutant;Mutation;Mutation Analysis;Neoplasm Metastasis;novel strategies;Outcome;overexpression;paralogous gene;Patient Selection;Pattern;Physiological;Play;Polymerase;preference;Process;prognostic;Reagent;reconstitution;recruit;Regulation;Resistance;Retroelements;RNA Viruses;Rodent;Role;scaffold;Sensitivity and Specificity;Single base substitution;Single-Stranded DNA;Site;Source;Surrogate Markers;System;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;Transgenes;Treatment Efficacy;tumorigenesis;Tyrosine Kinase Inhibitor;whole genome;Xenograft procedure

PROJECT_TITLE: Molecular origins and impact of APOBEC3 mutagenesis in cancer

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative - Overall The overall goal of the Skin Biology Resource-Based Center (SBDRC) at Mount Sinai is to accelerate research in skin biology and diseases and promote its translation to benefit human health. To achieve this, we will harness the technical innovations, high-end infrastructure and computing power available at Mount Sinai to specifically advance and innovate skin research by lowering cost barriers for skin researchers to access advanced technologies; embedding gene editing, genomics and bioinformatics experts in skin research labs to break down interdisciplinary communication barriers; and providing in person and virtual venues to facilitate collaboration and exchange of ideas. In parallel we will ensure a vibrant future for skin biology and diseases research by aiding entry of outside investigators through training and financial support; promoting development of junior investigators and physician-scientists; and enhancing the diversity of our research community through targeted recruitment and mentoring of minority scientists and by growing the pipeline of young minority students entering the field.

PI_NAMEs: EZHKOVA, ELENA  (contact)

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: Acceleration;Adoption;Advertising;analysis pipeline;Archives;Area;ATAC-seq;Award;Bioinformatics;Biology;Biometry;Candidate Disease Gene;Cells;ChIP-seq;Cleavage Under Targets and Release Using Nuclease;Clinical;Collaborations;combat;Communication;Communication Barriers;Communities;Complement;Consult;Consultations;cost;CRISPR/Cas technology;Data;Data Analyses;data integration;data visualization;Dermatology;design;Development;Disease;disease model;Educational process of instructing;Electronic Mail;Ensure;Environment;Epigenetic Process;Evaluation;exome sequencing;Faculty;Faculty Recruitment;Financial Support;Fostering;Funding;Future;gene editing technology;Gene Expression;Generations;Genes;genetic analysis;genome sequencing;Genomics;Geography;Goals;Grant;Health;Hi-C;High School Student;Hospitals;Human;human disease;human induced pluripotent stem cells;improved;Individual;Infrastructure;innovation;innovative technologies;Institution;Interdisciplinary Communication;Internships;Laboratories;laboratory experience;Leadership;member;Mentors;Minority;minority children;minority scientist;minority student;Modeling;Molecular;mouse model;Mus;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;New York;novel;outreach;Patients;Persons;Physicians;Population Heterogeneity;Positioning Attribute;Productivity;programs;racial disparity;recruit;Reporting;Research;Research Personnel;Resources;Sampling;Scholars Program;Scholarship;Scientist;screening;Services;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Skin;skin barrier;skin disorder;skin organogenesis;Small RNA;social media;Standardization;Structure;Study models;success;synergism;Technology;technology development;Testing;Therapeutic;Training;Training Support;transcriptome sequencing;transcriptomics;Translations;underserved minority;Universities;user-friendly;virtual;web site;whole genome

PROJECT_TITLE: Skin Biology and Diseases Resource-based Center at Mount Sinai


PROJECT_TITLE: CORE A: ADMINISTRATION


ORG_STATE: CA

PHR: PROJECT NARRATIVE HIV and other viral pandemics, including COVID-19, present substantial challenges to public health. The field needs new, talented investigators who can bring innovative solutions to address these continuing crises, a need that will be directly addressed by renewal of our highly successful, postdoctoral training program. The program now incorporates SARS-CoV-2 research, improves trainee productivity, and enhances recruitment of women and underrepresented minorities, with the objective of advancing early-stage investigators to independence so that they can address the continuing challenges of the HIV and other pandemics.

PI_NAMEs: GIANELLA WEIBEL, SARA ;LETENDRE, SCOTT L (contact)

PROJECT_TERMS: Grant;Training

PROJECT_TITLE: HOPE Training Grant


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Disability Research;Genetics;Muscular Dystrophy;Myotonic Dystrophy;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: NEUROLOGY

PHR: Project Narrative This is a comprehensive, prospective, cross-sectional study of brain structure and function in Myotonic Dystrophy type 2 (DM2). MRI measures of white matter integrity are expected to be identified as disease- specific and clinically relevant to clinical (cognitive and motor) endpoints and biofluid markers of brain pathology. This work is critical to inform the development of rigorous central nervous system (CNS) trial designs and plan for a longitudinal study to evaluate MRI measures of white matter integrity as imaging biomarkers for CNS disease progression and therapeutic response in DM2.

PI_NAMEs: PUWANANT, ARAYA  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Anisotropy;Antisense Oligonucleotides;Area;Attention;Biological Markers;Brain;Brain imaging;Brain Pathology;career;Central Nervous System;Central Nervous System Diseases;Cerebrospinal Fluid;Cerebrum;Clinical;Clinical Trials;clinically relevant;Cognition;Cognitive;Cognitive deficits;comparison control;Cross-Sectional Studies;Data;Deposition;Development;Diffusion Magnetic Resonance Imaging;disabling symptom;Disease;Disease Progression;drug development;Environment;executive function;Fostering;Foundations;Functional disorder;gain of function;Gait speed;Gene Proteins;Genetic;Genetic Diseases;Goals;gray matter;Hand Strength;Health Sciences;imaging biomarker;imaging study;Impaired cognition;improved outcome;interest;Knowledge;Lead;Liquid substance;Literature;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Memory;Mentors;Mentorship;Methods;morphometry;Motor;motor disorder;Muscle;Muscle Weakness;Myotonic dystrophy type 1;Myotonic dystrophy type 2;Neurobehavioral Manifestations;Neurobiology;Neurofibrillary Tangles;new therapeutic target;normal aging;nucleic acid binding protein;Pathology;Patients;Performance;Plasma;Preparation;processing speed;prospective;Protein Isoforms;Proxy;Quality of life;Radial;Reporting;Research;Research Personnel;RNA;RNA Splicing;Role;Sample Size;sex;skills;Structure;success;Symptoms;tau Proteins;tau-1;Testing;Training;treatment response;trial design;trial planning;Universities;verbal;white matter;Work

PROJECT_TITLE: Brain Structure and Clinical Endpoints in Myotonic Dystrophy Type 2

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Biotechnology;Genetics;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: RENDL, MICHAEL  (contact)

PROJECT_TERMS: Archives;Biological Process;Biology;Candidate Disease Gene;cell behavior;Cell model;Cell Physiology;Cell Separation;Cells;cellular imaging;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;comparative;Consult;Consultations;cost;CRISPR interference;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Derivation procedure;Dermal;Dermatopathology;Disease;disease model;Environment;epidermal stem cell;ex vivo imaging;Fibroblasts;fluorescence imaging;Fluorescence-Activated Cell Sorting;Functional disorder;gene correction;Gene Expression;Generations;Genes;Genetic;genetic analysis;Genetic Markers;Genetic Skin Diseases;Genetic study;Genetic Transcription;genome editing;Genomics;Goals;Grant;Habitats;Hair follicle structure;Histopathology;Homeostasis;Human;human disease;Human Genetics;human imaging;human induced pluripotent stem cells;human model;Image;imaging biomarker;Imaging technology;Immune;Improve Access;In Vitro;in vivo;induced pluripotent stem cell;induced pluripotent stem cell technology;Institution;interest;keratinocyte;Leadership;melanocyte;Merkel Cells;Modeling;Molecular Analysis;mouse genetics;mouse model;multiplexed imaging;Multiplexed Ion Beam Imaging;Mus;mutant;operation;overexpression;patient derived induced pluripotent stem cells;Patients;Physiological;Population;Production;protein biomarkers;Proteins;Protocols documentation;Research;Research Infrastructure;Research Personnel;Resources;Retrieval;sample archive;Sampling;Scholarship;Services;Skin;skin barrier;skin disorder;skin organogenesis;Skin Physiology;Skin Tissue;Slide;Stains;Surgeon;Technical Expertise;Technology;Therapeutic;therapeutic evaluation;therapeutic target;tongue papilla;Training;virtual

PROJECT_TITLE: Resource Core B - Modeling of skin disease for mechanistic analysis and therapeutic discovery


PI_NAMEs: BOWCOCK, ANNE MARY (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;Alternative Splicing;Anatomy;Animal Model;Area;ATAC-seq;Base Sequence;Binding Sites;Biological;biological systems;Biology;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Center Core Grants;ChIP-seq;Chromatin;Chromosomes;Cleavage Under Targets and Release Using Nuclease;Collaborations;Communities;Consultations;cost;Coupled;dashboard;Data;Data Analyses;data management;design;Development;Disease;disease classification;Disparate;Distant;DNA;DNA Sequence;DNA sequencing;Elements;Enhancers;Ensure;Epigenetic Process;epigenome;epigenomics;Epitopes;exome;exome sequencing;Experimental Designs;Faculty;Follow-Up Studies;Fostering;Funding;Gene Expression;Gene Expression Profiling;gene network;Genes;genetic analysis;Genetic Transcription;Genome;genome sequencing;genome wide association study;genome-wide;Genomics;Goals;Heterogeneity;Hi-C;histone modification;Histones;Homeostasis;Human Resources;improved;Individual;insight;Institution;instrumentation;Intake;Link;Location;Measurement;Medicine;member;Messenger RNA;Methods;Molecular Profiling;multiple omics;novel;Nucleic Acid Regulatory Sequences;Pathogenesis;Poly(A)+ RNA;Process;promoter;Protein Isoforms;Reagent;Regulatory Element;Research;Research Personnel;Research Project Grants;Resolution;Resources;risk variant;RNA;RNA Splicing;Scholarship;Service provision;Services;single cell analysis;single cell ATAC-seq;single cell sequencing;single cell technology;single molecule;single-cell RNA sequencing;Skin;skin disorder;skin organogenesis;Small RNA;Specimen;Standardization;Structure;Surveys;targeted sequencing;Technology;Therapeutic Intervention;Tissues;tool;Training;Transcript;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Validation;Variant;Visualization;whole genome

PROJECT_TITLE: Resource Core C - Skin Genomics, Transcriptomics, and Epigenetics Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE Prevention of Crimean Congo Hemorrhagic Fever remains a challenge because of a lack of human vaccines and any treatment options. This project will develop next-generation rhabdovirus-based vaccine platform to protect humans from infection.

PI_NAMEs: BENTE, DENNIS A;SCHNELL, MATTHIAS JOHANNES (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Adoptive Transfer;Africa;Animal Model;Animals;Antibodies;Antibody-mediated protection;Asia;Biological Assay;biosafety level 4 facility;Biotinylation;Bulgaria;Bunyavirales;Categories;CD8-Positive T-Lymphocytes;Cellular Assay;Classification;Clinical;Complement Activation;COVID-19 outbreak;Crimean Hemorrhagic Fever;Crimean-Congo Hemorrhagic Fever Virus;Disease;Disease Outbreaks;Dose;efficacy evaluation;efficacy study;Emerging Communicable Diseases;Enzyme-Linked Immunosorbent Assay;Europe;Evaluation;experimental study;Fatality rate;Flow Cytometry;Genes;Glycoproteins;Goals;Growth;Hand;hemorrhagic fever virus;high risk;Human;IFNAR1 gene;Immune response;Immunity;Immunize;immunogenicity;Inactivated Vaccines;Infection;Interferon alpha;Knock-out;Membrane;Middle East;Modeling;Monoclonal Antibodies;Mus;National Institute of Allergy and Infectious Disease;National Security;Needles;next generation;novel;pathogen;Patients;Predisposition;Prevention;priority pathogen;Production;protective efficacy;Public Health;Rabies virus;rabies virus glycoprotein G;receptor;Recombinants;research and development;Rhabdoviridae;Risk;RNA vaccine;RNA Viruses;Rodent Model;Route;Severity of illness;System;T-Lymphocyte;Testing;tick bite;Ticks;tool;transmission process;United States National Institutes of Health;Vaccinated;vaccine candidate;vaccine development;vaccine efficacy;vaccine platform;Vaccines;vector;vector tick;Vesicular stomatitis Indiana virus;Viral Genome;Viral Hemorrhagic Fevers;Viral Vector;Virion;Virus;Virus Diseases;Wild Type Mouse

PROJECT_TITLE: Analysis of a novel Crimean-Congo hemorrhagic fever vaccine and its mechanism of protection in rodent models

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Radiation Oncology;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative Radiation therapy to the brain is a mainstay of current treatment paradigms. Improved outcomes however have revealed latent cognitive toxicities that occur with high frequencies for as yet incompletely defined mechanisms. In the current application we examine a novel signaling pathway as a mediator of both cognitive damage and tumor radioresistance.

PI_NAMEs: WELFORD, SCOTT MICHAEL (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Acetylation;Adopted;adverse outcome;Apoptosis;Architecture;autocrine;Birth;Blood;Brain;Brain Glioblastoma;Brain Injuries;Brain Neoplasms;Cell Death;cell type;Cells;Central Nervous System;Cessation of life;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Cognition;Cognitive;Cognitive deficits;Conformal Radiotherapy;Cranial Irradiation;CRISPR/Cas technology;Dendrites;Disease;DNA Repair Gene;Dose Limiting;Effectiveness;Electrophysiology (science);Electroporation;Embryo;Enzymes;Event;Excitatory Amino Acid Antagonists;excitotoxicity;Exposure to;extracellular;Flow Cytometry;Frequencies;Gene Expression;gene therapy;Genetic Models;genome editing;glial activation;Glioblastoma;Glioma;Glutamate Metabolism Pathway;Glutamate Receptor;glutamatergic signaling;Glutamates;Glutamine;Hippocampus;Hour;ifenprodil;Immunocompetent;Immunotherapy;Impaired cognition;improved;improved outcome;in utero;inhibitor;innovation;insight;Invaded;Ionizing radiation;irradiation;Lesion;Link;Mediating;Mediator;Modality;Modeling;Morbidity - disease rate;Mus;N-Methyl-D-Aspartate Receptors;Nature;neoplastic cell;Nervous System Trauma;neuroinflammation;neuron loss;Neurons;neurotoxicity;Neurotransmitters;neutralizing monoclonal antibodies;Normal tissue morphology;novel;Organ;particle therapy;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Phosphorylation;Play;Polyamines;preclinical study;protective effect;Protons;Radiation;Radiation induced damage;Radiation Interaction;radiation resistance;Radiation therapy;Radiation Tolerance;radioresistant;Radiosensitization;Receptor Signaling;Resistance;Roentgen Rays;Role;Signal Induction;Signal Pathway;Signal Transduction;Slice;Specificity;standard of care;Structure;Synapses;System;Therapeutic;therapy resistant;Toxic effect;tumor;tumor growth;Tumor Promotion;Tumor Suppressor Genes

PROJECT_TITLE: Polyamine and Glutamate Driven Interactions in the Glioblastoma-Brain Microenvironment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-L(02)M]


PI_NAMEs: GUCCIONE, ERNESTO  (contact)

PROJECT_TERMS: Acceleration;Address;Antisense Oligonucleotides;ATAC-seq;Bioinformatics;bioinformatics tool;Biological;biological systems;Biology;Biometry;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;Collaborations;Communication;Communities;complex data;computerized tools;computing resources;Consultations;cost;Data;Data Analyses;data integration;data management;Data Reporting;Data Set;data sharing;data tools;data visualization;Databases;design;Development;Disease;diverse data;Education;Educational workshop;Ensure;Evolution;exome sequencing;experience;Experimental Designs;experimental study;Fees;Funding;Future;Genes;Genomics;Goals;Hi-C;Homeostasis;Human Resources;Image;improved;Individual;innovation;large datasets;Leadership;meetings;Methodology;Multiomic Data;Multiplexed Ion Beam Imaging;novel;Output;prevent;process repeatability;Proteomics;Randomized;Reporting;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;RNA Splicing;Sample Size;Scholarship;Services;single cell ATAC-seq;single-cell RNA sequencing;Skin;skin organogenesis;Slide;Stains;Standardization;Statistical Data Interpretation;Statistical Models;statistics;synergism;Technology;tool;Training;Training and Education;transcriptomics;Visualization;web-based tool;whole genome;Work

PROJECT_TITLE: Resource Core D - Bioinformatics and Statistical Analysis Core


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Machine Learning and Artificial Intelligence;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Image-guided minimally invasive interventions, including targeted biopsy and focal ablation, promise to be safe and effective strategies for the diagnosis and treatment of abdominal cancers, but currently face critical limitations due to inadequate image guidance and procedural accuracy provided by existing technologies. This work will overcome these challenges by creating a new real-time magnetic resonance imaging (MRI) guided robotic system based on synergistic innovations in real-time MRI and computer-aided guidance methods, MRI-compatible robotics, feedback control methods, and interactive user interfaces. The new system will be evaluated in programmable dynamic tissue phantoms and in vivo pig liver models to demonstrate its safety, accuracy, and efficiency for needle placement in moving targets, which will establish the foundation for a new generation of minimally invasive interventions to improve the management of abdominal cancers.

PI_NAMEs: LU, DAVID S.K.;TSAO, TSU-CHIN TC;WU, HOLDEN H (contact)

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: 3-Dimensional;Abdomen;Ablation;accurate diagnosis;Biopsy;Breathing;bulk motion;Cancer Etiology;Cancerous;Cessation of life;clinically relevant;Computer Assisted;Computer software;curative treatments;Data;deep learning;Devices;Diagnosis;Diameter;Early Diagnosis;Effectiveness;Engineering;Excision;experimental study;Face;Family suidae;Feedback;fly;Foundations;Freedom;Frequencies;Generations;Human;human subject;Image;image guided;improved;in vivo;innovation;innovative technologies;Interdisciplinary Study;Intervention;Ionizing radiation;Length of Stay;Lesion;Liver;Liver neoplasms;Magnetic Resonance Imaging;Malignant neoplasm of abdomen;Malignant Neoplasms;Mechanics;Methods;minimally invasive;Modeling;Morbidity - disease rate;Morphologic artifacts;mortality;Motion;Needles;new technology;next generation;Normal tissue morphology;Operative Surgical Procedures;Organ;Patients;Penetration;Physicians;Physiological;porcine model;Pre-Clinical Model;predictive modeling;preservation;Primary carcinoma of the liver cells;Procedures;Radial;radiologist;real-time images;Robot;robotic system;Robotics;Safety;Scanning;Scientist;simulation;Slave;Slice;soft tissue;Structure;success;Survival Rate;System;Techniques;Technology;Testing;Time;tissue phantom;Tissues;transmission process;tumor;ultrasound;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: New Technologies for Real-Time MRI-Guided Robotic-Assisted Abdominal Interventions

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]