PHR: Project Narrative Food allergy affects 8% of the US population and is a significant economic and quality of life burden; food allergy also disproportionately affects Black and Hispanic populations. To develop new prevention and treatment approaches, diverse groups of scientists with interest and innovate research in and around food allergy topics need to be gathered to spark collaboration and novel research ideas. This is the objective of the 2024 joint Food Allergy Gordon Research Conference and Gordon Research Seminar.

PI_NAMEs: EISENBARTH, STEPHANIE CAROLINE (contact)

PROJECT_TERMS: Acceleration;Accidents;Affect;Allergen Immunotherapy;Allergic;allergic response;Allergy to peanuts;Area;Basic Science;Behavior;Black Populations;career;Clinical;clinical care;Clinical Investigator;Clinical Trials;Code;Collaborations;Communities;Consensus;Creativeness;Diet;dietary;Discipline;Disease;diversity and inclusion;Economics;Event;experience;FDA approved;Food;food allergen;Food Hypersensitivity;Fright;Functional disorder;Gender Identity;Genetic;Geographic Locations;Goals;Growth;Guidelines;Hispanic Populations;Hour;Human;Hypersensitivity;Immune;Immune Tolerance;Immunity;Immunology;improved;Infant;innovation;insight;Institution;Interdisciplinary Study;interest;Investments;Joints;Knowledge;Language;Life;meetings;Mentors;microbiome;Modification;Molecular;mouse model;Nervous System;neuroimmunology;new therapeutic target;next generation;novel;novel therapeutics;oral immunotherapy;outreach;Participant;Pharmaceutical Preparations;Physicians;Policies;Population;Population Genetics;prevent;Prevention;Process;programs;Quality of life;Race;racial disparity;racial diversity;Reaction;Recommendation;recruit;Research;Research Personnel;Risk;Science;Scientist;Sexual Harassment;Shapes;Skin;symposium;System;Time;translational scientist;Underrepresented Populations;verbal

PROJECT_TITLE: 2024 Food Allergy Gordon Research Conference & Gordon Research Seminar


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: East Greenwich

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative The 2024 Gordon Research Conference on the Neurobiology of Cognition, the seventh meeting on this theme, will bring together leading experts and trainees for a weeklong meeting designed to foster growth and collaboration in this exciting field. The conference will be preceded by the Gordon Research Seminar on this topic, geared toward graduate student and postdoc attendees. Topics to be discussed at these events include key aspects of cognition such as attention, memory, perception, action, and new this year, affect and communication.

PI_NAMEs: BATISTA, AARON PAUL (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Acceleration;Affect;Area;Attention;Behavior;Behavioral;career;case-by-case basis;Cognition;Cognition Disorders;Cognitive;cognitive neuroscience;Collaborations;Communication;Computer Models;Decision Making;design;Development;Discipline;early-career faculty;educational atmosphere;Emotions;Ensure;Event;experience;Female;Fostering;Functional Imaging;Funding;Goals;graduate student;Growth;Growth and Development function;Health;Human;improved;Individual;insight;Investigation;Knowledge;Laboratories;Life;Link;meetings;member;Memory;Molecular;neural circuit;Neurobiology;neurophysiology;Neurosciences;Neurosciences Research;nonhuman primate;novel;Parents;Perception;Personal Satisfaction;Postdoctoral Fellow;Primates;Process;programs;Psyche structure;Recording of previous events;Recreation;Relaxation;remote location;Request for Proposals;Research;Research Personnel;Rodent;Scientist;Series;social communication;Specific qualifier value;Structure;symposium;System;Techniques;Time;Underrepresented Populations;Woman

PROJECT_TITLE: 2023 Neurobiology of Cognition Gordon Research Conference & Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-P (11)]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: CLEVELAND

ORG_DEPT: SURGERY

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Orthopaedic clinician scholars generate significant contributions to the field of orthopaedics. Unfortunately, due to a variety of factors in the healthcare environment, the number of surgeon- scientists has been on the decline in recent years. The Clinician Scholar Career Development Program offers the orthopaedic profession a new source of clinician scientists engaged in research that advances orthopaedic surgery and musculoskeletal medicine.

PI_NAMEs: SPINDLER, KURT PAUL (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Academy;Address;American;Arthritis;Awareness;Back Pain;Basic Science;Bone Morphogenetic Proteins;career;career development;career life balance;career networking;Clinic;Clinical;Clinical Research;clinically relevant;Collaborations;Communication;Competence;Department chair;Education;Educational workshop;Environment;experience;Exposure to;Faculty;faculty mentor;Fellowship;Fostering;Foundations;Fracture;Funding;Funding Mechanisms;Funding Opportunities;Goals;Grant;Grant Review;Growth;Health Care Reform;Healthcare;Individual;innovation;insight;interest;invention;Knowledge;Leadership;Learning;lectures;Medicine;meetings;member;Musculoskeletal;Operating Rooms;Orthopedic Surgery;Orthopedics;Participant;Pathway interactions;Patient Care;Patients;Peer Review;Positioning Attribute;Principal Investigator;Procedures;Process;Program Development;programs;Publishing;recruit;Replacement Arthroplasty;Research;Research Personnel;Residencies;Resources;responsible research conduct;Scientist;skill acquisition;skills;Societies;Soft Tissue Injuries;Source;Spinal Fusion;success;Surgeon;Surveys;Time;timeline;Training;Translational Research;United States National Institutes of Health

PROJECT_TITLE: Clinical Scholars Career Development Program (CSCDP)

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: AG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: FAIRBANKS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ALASKA FAIRBANKS

ORG_STATE: AK

PHR: The major goal of this conference is to serve as a driving force for cutting-edge discussions and formulation of experiments and collaborations that open new areas of exploration of energy metabolism underlying cognition, energy homeostasis and alterations in aging, Alzheimer’s disease, and Alzheimer’s disease related dementias. This small, focused conference centers on brain energy metabolism and brings together the world's experts, with strong emphasis on participation by women, young investigators, students, and postdoctoral fellows in formal presentations and informal discussions which are a highlight of the meeting. This unique, `investigator initiated' conference series has a long history with strong conceptual, experimental, and collaborative contributions to address controversial areas in the field, and to address development of new approaches to address difficult issues that underlie Alzheimer’s disease, Alzheimer’s disease related dementias and cognitive decline.

PI_NAMEs: DREW, KELLY L (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Achievement;Address;age-related disease;Aging;aging brain;aging related disease;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Animal Model;Area;Astrocytes;Ataxia;Award;Bioenergetics;biomarker identification;Brain;brain metabolism;career;Clinical;clinically relevant;Cognition;Collaborations;Communities;community engagement;Coupling;Development;Disease;driving force;Energy Metabolism;Environment;Evaluation;Event;experimental study;Formulation;Fostering;Future;Generations;Goals;healthy aging;Homeostasis;Hybrids;Image;imaging modality;imaging scientist;Impaired cognition;Impairment;injured;International;Internet;Leadership;Lipids;Location;meetings;member;Metabolic;Metabolism;Mitochondria;Modality;Monitor;Nerve Degeneration;neurochemistry;Neurodegenerative Disorders;neuroimaging;neuronal metabolism;Neurons;neurophysiology;Neurosciences;neurovascular;neurovascular coupling;novel;novel strategies;Participant;permissiveness;Persons;Postdoctoral Fellow;programs;Radiology Specialty;Recording of previous events;Regulation;Research;Research Personnel;resilience;Role;Scientist;Series;Slovenia;Structure;Students;symposium;Techniques;Time;trafficking;Travel;Woman;Work

PROJECT_TITLE: 15th International Conference on Brain Energy Metabolism: Brain Bioenergetics in Aging - Neurovascular and Neurometabolic Coupling and Fuels

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Narrative This proposal evaluates the importance of alveolar macrophage EphA2 β-glucan receptor signaling in host responses to Pneumocystis. Furthermore, we will determine the importance of EphA2 activity in vivo during Pneumocystis pneumonia (PCP) in the CD4 depleted mouse model through analysis of lung inflammation, organism killing, and eventual outcome. Observations from these studies will aid in understanding PCP, and guide development of novel therapeutic approaches targeting this pathway for PCP, for patients who are refractory or fail standard antibiotic therapy.

PI_NAMEs: LIMPER, ANDREW H (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Alveolar Macrophages;Antibiotic Therapy;Antibiotics;Atherosclerosis;beta-glucan receptor;beta-Glucans;Binding;Carbohydrates;CD4 Positive T Lymphocytes;Cell Wall;Cells;cytokine;Data;data modeling;Development;Endothelial Cells;EphA2 Receptor;Ephrins;Epithelial Cells;Epithelium;Exhibits;extracellular;Family;Flow Cytometry;fungus;Future;Goals;Host Defense;Immune;immune function;Immune response;Immunity;Immunocompetent;Immunocompromised Host;immunosuppressed;In Vitro;in vivo;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Inflammatory Response Pathway;inhibitor;insight;interstitial;Kinetics;Knockout Mice;Ligands;Light;Link;Lung;Lung infections;lung injury;Macrophage;Malignant Neoplasms;MAPK3 gene;Mediating;member;Membrane;Modeling;monocyte;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;Mycoses;Myeloid Cells;Natural Immunity;novel;novel strategies;novel therapeutic intervention;Observational Study;oral cavity epithelium;Organism;oropharyngeal thrush;Outcome;Pathogenesis;pathogenic bacteria;pathogenic fungus;pathogenic microbe;pathogenic virus;Pathologic Neovascularization;Pathway interactions;Patients;Phosphotransferases;Pneumocystis;Pneumocystis carinii Pneumonia;pneumonia model;Population;Publishing;Pulmonary Inflammation;receptor;Receptor Protein-Tyrosine Kinases;Receptor Signaling;recruit;Refractory;Regulatory Pathway;response;Role;Signal Pathway;Signal Transduction;Source;Stat3 protein;Surface;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Time;Tissues;Tyrosine Kinase Domain;uptake;Wild Type Mouse

PROJECT_TITLE: The Role of the EphA2 Receptor Kinase Pathway in Pneumocystis Pneumonia (PCP)

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: RESTON

ORG_NAME: SOCIETY OF TOXICOLOGY

ORG_STATE: VA

PHR: Project Narrative Toxicology is a discipline and profession that is dedicated to identifying the adverse effects of chemical, physical, and biological agents on living organisms and the ecosystem and to preventing and ameliorating such adverse effects. As a mini conference embedded in the Society of Toxicology (SOT) Annual Meeting, the SOT Undergraduate Diversity Program supports a critical need during the undergraduate years: by immersing students from groups underrepresented in the sciences in a disciplinary science meeting, we encourage them to prepare for and apply to graduate school in the biomedical sciences, thus strengthening the pipeline of future toxicologists. Apart from further developing the talent pool, the SOT meeting and this program benefit public and environmental health by advancing research to protect society and the environment from adverse health risks resulting from exposures to hazardous agents.

PI_NAMEs: MANAUTOU, JOSE E (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Academia;academic program;Access to Information;Adverse effects;Awareness;Biological Products;career;career awareness;Career Choice;Case Study;Chemicals;Communication;Communities;Dedications;Discipline;diversity and inclusion;Doctor of Philosophy;Ecosystem;Education;Employment;Environment;Environmental Health;Evaluation;experience;Exposure to;Faculty;follow-up;Funding;Future;Generations;Government;Graduate Education;graduate school;graduate student;Health;Health protection;Hearing;Industry;Institution;interest;Internships;Laboratory Research;Learning;meetings;Mentors;Methods;next generation;Organism;parity;Participant;peer coaching;Population;posters;prevent;programs;Public Health;Qualifying;Recording of previous events;Research;Resources;Risk;Science;Scientist;Societies;Students;summer internship;summer research;symposium;Talents;Toxicology;Training;Travel;undergraduate student;Underrepresented Populations;Visit;web site;Work

PROJECT_TITLE: Society of Toxicology Undergraduate Diversity Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 ARL-W (13)]


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: MORGANTOWN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative Practice-based research networks (PBRN) a critical element to conduct clinical studies that impact health outcomes in real-world conditions and now a required element of the the National Institute of General Medical Sciences Clinical and Translational Research IDeA (CTR) program. The goal of a planned in-person summit will be to establish relationships, create a strategic plan for the national group to facilitate research collaborative, and to share our discussions and findings during the summit through a manuscript.

PI_NAMEs: HODDER, SALLY LYNN (contact)

PROGRAM_OFFICER_NAME: BISSONETTE, GREG

PROJECT_TERMS: Achievement;Address;Automobile Driving;Award;care outcomes;Clinic;Clinical;Clinical Medicine;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;Community Health;community setting;Conduct Clinical Trials;design;Development;Elements;experience;Face;Foundations;Future;Goals;Health;health disparity;health inequalities;Health Professional;Healthcare;improved;insight;Institution;Manuscripts;meetings;member;Minority Groups;Minority Recruitment;Mission;National Institute of General Medical Sciences;Network Infrastructure;novel strategies;Outcome;Output;Parents;Patients;Persons;Population;practice-based research network;Primary Care;primary care patient;primary care practice;programs;recruit;Research;research in practice;Research Infrastructure;Research Support;Resources;Rural;Rural Community;Rural Population;Site;Spanish/English;special interest group;Strategic Planning;success;support network;symposium;Translational Research;translational research program;Underrepresented Minority;Underrepresented Populations;underserved community;Underserved Population;United States;West Virginia

PROJECT_TITLE: Institutional Development Award in Clinical and Translational Research (IDeA-CTR) Practice-Based Research Network Summit

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TRN-7 (CF)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN ANTONIO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative Latinos represent the largest racial/ethnic minority group in the United States and experience profound cancer-related health disparities. The biennial ASCL conference (2018, 2020, 2022) has met a tremendous need for researchers interested in identifying equitable solutions to address Latino health disparities through multidisciplinary collaborations. The 2024 ASCL conference will do the same with a special focus on exploring the intersection of health equity, biology, and cultural paradigms on cancer control, prevention, and treatment.

PI_NAMEs: RAMIREZ, AMELIE G (contact)

PROGRAM_OFFICER_NAME: MOMIN, BEHNOOSH RAMJI

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Advocate;Biology;Cancer Center;Cancer Control;cancer diagnosis;cancer health disparity;cancer prevention;Cancer Science;Chronic Disease;Clinical;Collaborations;Communities;community intervention;Death Rate;Diagnosis;differences in access;Disparity;Equity;ethnic minority population;experience;Feedback;Goals;Health;health disparity;health equity;Health Professional;Health Promotion;Health Services Accessibility;improved;Interdisciplinary Study;interest;Latino;Latino Population;Malignant Neoplasms;member;NCI-Designated Cancer Center;Outcome;outcome disparities;Patients;Physicians;Population;Prevention;racial minority population;Research;Research Personnel;response;screening;South Texas;Students;symposium;Testing;Texas;Training Programs;Translating;United States

PROJECT_TITLE: Advancing the Science of Cancer in Latinos 2024

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (O1)]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative The proposal aims to partially support the premier conference on the topic of biointerface science. This area is fundamental to accelerating the development of biosensors, tissue engineering, immunotherapy, and also in understanding design principles in cell biology and biomedical engineering. The meeting will also enhance the diversity of the biomedical workforce by encouraging participation for individuals from underrepresented groups.

PI_NAMEs: SALAITA, KHALID S. (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Acceleration;Address;Area;Behavior;Biological;biological systems;Biology;biomaterial compatibility;Biomedical Engineering;Biosensing Techniques;Biosensor;Biotechnology;career;Cell surface;Cellular biology;Chemicals;Chemistry;citizen science;Collaborations;Communities;Complement;design;Development;Diagnosis;Diagnostic;Discipline;DNA;Engineering;experience;Faculty;Fertilization;frontier;fundamental research;Goals;Hour;human disease;Immunologic Receptors;Immunotherapy;Implant;Individual;International;Investigation;Italy;Macromolecular Complexes;Measurement;mechanical signal;Medical;Medicine;meetings;minority scientist;Mission;Molecular;nanoscale;Nanostructures;National Institute of Allergy and Infectious Disease;National Institute of Biomedical Imaging and Bioengineering;Oral;Organism;Participant;physical science;Physics;Play;Postdoctoral Fellow;posters;Productivity;programs;real world application;Receptor Signaling;Regenerative Medicine;Research;Research Personnel;Robotics;Role;Science;Scientist;social;Students;Surface;symposium;synthetic biology;System;Technology;technology development;Tissue Engineering;tool;Translations;Underrepresented Minority;Underrepresented Populations;Woman;Work

PROJECT_TITLE: R13 for Gordon Research Conference on Biointerface Science: Molecular Engineering, Measurement and Manipulation at the Boundary between Living Systems and Synthetic Materials

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (O1)]


NIH_SPENDING_CATS: Aging;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE There is a need for a racially diverse workforce of gerontologists. HBCUs are well integrated in the discipline, but with limited resources. This conference series will provide professional development and networking opportunities for HBCU emerging scientists, while ensuring that aging communities have access to culturally competent and equitable care.

PI_NAMEs: BAKER, TAMARA A (contact);ESIAKA, DARLINGTINA ;NWAKASI, CANDIDUS

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Advocacy;Advocate;African American student;Aging;aging population;aluminum sulfate;Award;Bachelor's Degree;Biomedical Research;Black race;career;Caring;Collaborations;Communities;Competence;cultural competence;cultural equity;Development;Discipline;Diverse Workforce;Education;Educational workshop;Elderly;Engineering;Enrollment;Ensure;Faculty;Fellowship;Fostering;Future;Geriatrics;Gerontology;Goals;graduate student;Health Personnel;Historically Black Colleges and Universities;improved;Individual;Influentials;Institution;Instruction;Interest Group;International;Knowledge;knowledge hub;Lawyers;Leadership;Learning;meetings;member;Mentors;Minority;minority engagement;Minority-Serving Institution;Mission;multidisciplinary;Outcome;Positioning Attribute;Postdoctoral Fellow;Preparation;Privatization;programs;Publishing;racial disparity;racial diversity;recruit;Relationship-Building;Research;Research Personnel;Resource Sharing;Resources;Role;Scholarship;Science;Scientist;Series;skills;Societies;Structure;support network;symposium;Training;Training Support;undergraduate student;United States National Institutes of Health;university student

PROJECT_TITLE: Elevating efforts to recruit and retain HBCU scholars in the field of aging


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Neurosciences

ORG_CITY: SILVERTHORNE

ORG_NAME: KEYSTONE SYMPOSIA

ORG_STATE: CO

PHR: PROJECT NARRATIVE The barrier surfaces of multicellular organisms include tissues that are often exposed to infectious agents and factors that contribute to chronic inflammatory diseases such as asthma, allergy, inflammatory bowel diseases and cancer. Yet, there is still much to learn about the complex interplay between these tissue barrier sites, microbial factors, and inflammatory mediators. This conference was designed to bring together experts in innate and adaptive immunity, host-microbiota interactions and neuroscience to foster collaborations between scientists, engage young investigators in the field, and to accelerate research progress in barrier immunity that will lead to the development of new treatments for complex immune disorders and cancer.

PI_NAMEs: SHEPPARD, TERRY L. (contact)

PROGRAM_OFFICER_NAME: BARTELS, ADELINA EWURA-ABENA

PROJECT_TERMS: Acceleration;adaptive immunity;Address;Afferent Neurons;Alberta province;Antigen-Antibody Complex;Area;Asthma;Atopic Dermatitis;Canada;career development;Cells;chronic inflammatory disease;Clinical;clinical practice;Collaborations;Communicable Diseases;Communities;Complex;design;Development;Discipline;Disease;Educational workshop;Electronic Medical Records and Genomics Network;Environment;Environmental Risk Factor;Epithelium;Exposure to;Fostering;frontier;Genetic;Goals;Health;Hematopoietic;host microbiota;host-microbe interactions;Hypersensitivity;Immune system;Immune System Diseases;Immunity;Immunologics;Immunologist;Immunology;improved;Industrialization;Infection;Infectious Agent;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Bowel Diseases;interest;International;Kenya;Knowledge;Learning;Malignant Neoplasms;member;Methodology;microbial;microbiota;multidisciplinary;Natural Immunity;Nervous System;Neurons;Neurosciences;new therapeutic target;novel therapeutic intervention;Organism;Outcome;Pathway interactions;Physiology;posters;Regulation;Research;Research Personnel;Role;Scientist;Sensory;Signal Transduction;Site;sound;Stromal Cells;Surface;symposium;System;tissue repair;Tissues;treatment strategy;Work

PROJECT_TITLE: Regulation of Barrier Immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 BJM-D (S2)]


NIH_SPENDING_CATS: Bioengineering;Cancer

ORG_CITY: ARLINGTON

ORG_NAME: BIOMEDICAL ENGINEERING SOCIETY

PHR: Project Narrative The goal of this application is to support travel awards for students, post-doctoral fellows, and early-stage investigators (Rising Stars), with aim to enhance participation by groups underrepresented at the 2024-26 BMES Cellular and Molecular Bioengineering (CMBE) Conferences. The theme of the 2024 BMES CMBE Conference is “Systems Bioengineering: From Molecules to Cells to Tissues” which present an integrated viewpoint of complex biological systems with focus on the immune system.

PI_NAMEs: COSGROVE, BENJAMIN DAVID (contact)

PROJECT_TERMS: 3-Dimensional;Adoption;Area;Atlases;Award;Basic Science;bioimaging;Biological Models;Biological Process;biological systems;Biology;Biomedical Engineering;Biosensor;career;Cells;Chemistry;clinical translation;Communities;Complex;complex biological systems;Cues;Data Science;Development;Diagnostic;Discipline;Disease;Disparate;Drug Screening;Education and Outreach;Engineering;Environment;Epigenetic Process;Event;Exposure to;extracellular;Faculty;Fostering;Funding;Genomics;Goals;graduate student;Guidelines;Human body;human disease;Humanities;Immune system;Industry;interdisciplinary collaboration;Journals;Letters;Location;meetings;member;Mentors;Methods;Modeling;Molecular;new technology;Outcome;Paper;Pathway interactions;Postdoctoral Fellow;posters;programs;Published Comment;Publishing;Puerto Rico;recruit;Recruitment Activity;Research;Research Personnel;single cell technology;Societies;Strategic Planning;Structure;Students;symposium;synthetic biology;System;Techniques;Technology;Time;Tissues;tool;Translating;Translational Research;Translations;Travel;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;university student;Vision;Woman

PROJECT_TITLE: 2024-2026 Biomedical Engineering Society (BMES) Cellular and Molecular Bioengineering (CMBE) Conference


NIH_SPENDING_CATS: Biotechnology;Cancer;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: IMAT R61 Narrative A major challenge in cancer is how to combat treatment resistant properties of cancer stem cells (CSCs) which drive tumor recurrence and progression. Here we develop a novel high-throughput screening platform that reports changes in CSC electrical properties and cell proliferation in response to ion channel drugs. The changes in electrical properties and proliferation are expected to identify drugs that “reprogram” CSCs to more treatment responsive states which can be used in combination with current or future therapies to improve treatment responses and outcomes for cancer patients.

PI_NAMEs: ROSTOMILY, ROBERT C (contact);ST-PIERRE, FRANCOIS

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Address;Basic Science;Biological Assay;Biology;cancer cell;Cancer Patient;cancer stem cell;cancer therapy;Cardiac;Cardiovascular Diseases;Cell Culture Techniques;Cell Cycle;Cell Differentiation process;Cell Line;Cell membrane;Cell Proliferation;Cell Therapy;Cells;cellular engineering;clinical translation;clinically relevant;cohort;combat;Development;Disease;drug candidate;Drug Evaluation;Drug Modulation;Drug Targeting;electrical property;Electrodes;Electrophysiology (science);Ensure;Exhibits;experimental study;FDA approved;Frequencies;Funding Mechanisms;Future;Genetic Engineering;genotoxicity;Glioblastoma;high reward;high risk;high throughput analysis;high throughput screening;high throughput technology;Human;Image;improved;In Vitro;in vivo;induced pluripotent stem cell;innovation;Intervention;Ion Channel;Libraries;Malignant - descriptor;Malignant Neoplasms;Measurement;Measures;Membrane;Membrane Potentials;molecular subtypes;Monitor;Morphogenesis;multidisciplinary;Neoplasm Metastasis;nerve stem cell;Neurons;Neurosciences;new technology;Normal tissue morphology;novel;novel strategies;Oranges;patch clamp;Performance;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Physiological;Physiology;Population;prevent;primary endpoint;programs;Proliferating;Property;Proteins;Recurrent tumor;Regulation;Reporter;Reporting;Reproducibility;Research;Resistance;response;Role;Sampling;secondary endpoint;self-renewal;sensor;serial imaging;Side;side effect;stable cell line;Stem Cell Assay;stem cell therapy;stem cells;stem-like cell;success;Techniques;Technology;technology development;technology platform;Testing;Therapeutic;therapy resistant;Time;tool;Toxic effect;translational applications;Treatment outcome;treatment response;tumor growth;tumor progression;Undifferentiated;voltage;voltage sensitive dye

PROJECT_TITLE: A multiplexed high-throughput platform to report pharmacologic alteration of cancer stem cell membrane potential and cell cycle state

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-D (O1)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The Cell and Molecular Pharmacology Training Program seeks to provide students with interdisciplinary training and state-of-the-art education in pharmacological sciences. Didactic and experiential efforts combine to deliver professional and soft skills that prepare graduates for careers in academia, industry, public policy and science education, where understanding drug action and knowledge of biomedical sciences are needed.

PI_NAMEs: BROWN, JOAN HELLER (contact);HANDEL, TRACY M

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TITLE: Cellular and Molecular Pharmacology Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: Los Angeles

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Many novel cancer therapies have been developed to target genomic instability, which is a hallmark and a driving force of cancer. These new therapies are currently moving from the lab to the clinic, and we are poised for a rapid expansion of new DNA repair pathway-targeting drugs that will be used to eliminate different types of cancer. The 2023 SoCal Genome Stability Symposium will focus on research related to genomic instability and its implications in cancers and therapies.

PI_NAMEs: CHIOLO, IRENE E (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Address;Area;Atmosphere;Awareness;California;cancer recurrence;cancer therapy;cancer type;career;career development;Cells;Chemicals;Clinic;Collaborations;Communities;Disabled Persons;disadvantaged background;DNA;DNA Damage;DNA Repair;DNA Repair Pathway;driving force;Drug Targeting;environmental mutagens;Ethnic Population;experience;Exposure to;Faculty;Feedback;Fostering;frontier;Future;Gender;Genome Stability;Genomic Instability;Goals;graduate student;improved;Individual;Institution;Laboratories;Los Angeles;Malignant Neoplasms;marginalized population;meetings;member;Mentors;Mutagenesis;novel;novel therapeutics;Oral;peer;Positioning Attribute;Postdoctoral Fellow;posters;Principal Investigator;racial population;Research;response;Science;Science, Technology, Engineering and Mathematics;Scientist;Senior Scientist;Sex Orientation;Signal Transduction;socioeconomic disadvantage;Students;symposium;Time;Underrepresented Populations;Universities;Woman

PROJECT_TITLE: 2023 SoCal Genome Stability Symposium


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: Type 2 diabetes (T2D) affects over 20% of all veterans, putting them at risk for serious complications, including vision loss, renal failure, heart attacks, and amputations. T2D is caused by diminished insulin secretion from insulin-producing pancreatic islets and reduced response to insulin. Insoluble protein aggregates, called amyloid, within and around T2D islets may contribute to islet dysfunction. To help identify new approaches to prevent and treat T2D, we are investigating how islet amyloid affects function and health of the various cell types within the human pancreatic islet. We will leverage innovative approaches including genetic manipulation of human islet cells, intra-vital imaging of transplanted human islets, and single nuclear transcriptomic profiling, to study how interactions between the receptor for advanced glycation endproducts (RAGE) and islet amyloid influences islet health in the in vivo context.

PI_NAMEs: WRIGHT, JORDAN JAMES (contact)

PROJECT_TERMS: Affect;Alpha Cell;Alzheimer's Disease;Amputation;amylin receptor;Amyloid;amyloid formation;anterior chamber;Apoptosis;Area;Behavior;Beta Cell;Binding;Bioinformatics;Biology;Blindness;Blood Vessels;career development;Cell Death;Cell Membrane Permeability;Cell Survival;cell type;Cells;Cellular biology;collaborative environment;Communication;cost;Data Science;Deposition;Development;Development Plans;Developmental Biology;Diabetes Mellitus;diabetes pathogenesis;Disease;Education;endoplasmic reticulum stress;Etiology;experimental study;extracellular;eye chamber;Foundations;Functional disorder;Gene Expression;Gene Expression Profile;genetic manipulation;Genetic Transcription;Glucagon;Health;Human;human tissue;Hyperglycemia;Imaging Techniques;Immunoglobulins;Immunology;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory;innovation;Insulin;Insulin Resistance;insulin secretion;International;intravital imaging;islet;islet amyloid polypeptide;Islet Cell;Islets of Langerhans;Kidney Failure;knock-down;Knockout Mice;Knowledge;Laboratories;Ligands;longitudinal analysis;Measurement;Measures;Mediating;member;Mentors;Mentorship;Methodology;Methods;Modeling;Molecular;Monitor;mouse model;multidisciplinary;Mus;Myocardial Infarction;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Nuclear;Nuclear RNA;Oxidative Stress;Pathogenesis;Pattern recognition receptor;Physiology;prevent;Process;programs;protein aggregation;Reagent;receptor;Receptor Activation;receptor binding;receptor for advanced glycation endproducts;receptor-mediated signaling;Reporting;Research;Research Design;response;Risk;Rodent;Rodent Model;Role;Signal Pathway;Signal Transduction;skills;small hairpin RNA;Structure;Structure of alpha Cell of islet;Techniques;Technology;Testing;Time;Toxic effect;Training;transcriptome sequencing;transcriptomic profiling;Transgenic Mice;Transplantation;Veterans;Viral;Visualization;Work

PROJECT_TITLE: In vivo mechanisms of amyloid-induced pancreatic islet dysfunction in type 2 diabetes


ORG_CITY: Decatur

PHR: Limb salvage is a major health issue for Veterans with diabetes and peripheral arterial disease. The increasing incidence of diabetes and peripheral arterial disease and the clinical plateau of therapeutic options make this a critical and national issue. This proposal seeks to overcome current barriers and develop a translational platform for regenerative medicine in our Veteran population.

PI_NAMEs: BREWSTER, LUKE PACKARD (contact)

PROJECT_TERMS: Acute;Affect;Amputation;Arteries;Biology;Blood Platelets;Blood Vessels;CCL2 gene;Cell secretion;Cell Therapy;Cell Transplantation;Cells;Clinical;comparison control;Data;Defect;delivery vehicle;Diabetes Mellitus;diabetic;diabetic patient;diabetic ulcer;effectiveness testing;Endothelial Cells;experience;fetal bovine serum;Fibrin;Gel;Glucose;Goals;Health;Hindlimb;Human;Hydrogels;immunoregulation;Impairment;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;in vivo regeneration;Incidence;Inflammation;Interdisciplinary Study;Ischemia;Leg;Limb Salvage;Macrophage;Mesenchymal Stem Cells;Methods;military veteran;Molecular;mouse model;Natural regeneration;Nude Mice;optimism;paracrine;Pathway interactions;Patient Recruitments;patient retention;Patients;Perfusion;Peripheral arterial disease;Peripheral Blood Stem Cell;Phenotype;PIK3CG gene;premature;prevent;recruit;regeneration function;regenerative;regenerative approach;Regenerative capacity;regenerative cell;Regenerative Medicine;repaired;Research;revascularization surgery;Risk;senescence;Signal Transduction;stem cell therapy;Testing;Therapeutic;Therapy trial;Tissue Transplantation;Tissues;Translating;Vascular blood supply;Vascular regeneration;Veterans;Work

PROJECT_TITLE: Molecular Repair of Diabetic Mesenchymal Stem Cells (dMSC) for Peripheral Arterial Disease


ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

PHR: Project Narrative We will impact Veteran’s healthcare by improving on-going access to VA multidisciplinary care services to Veterans with HIV by facilitating the implementation of VA Video Connect (VVC). VVC is a VA-supported mobile health video technology that allows Veterans and providers to complete clinical visits from any remote location including the home. We will test whether we can increase Veterans use of VVC in the HIV clinic in the Houston VA, identify the impact of VVC on the Veterans health, and then conduct work to facilitate implementation in HIV clinics in 6 other VA centers throughout the US. VVC is a disruptive technology that can change the way vulnerable Veterans receive primary care, specialty care, social services, and mental health. This project will provide the evidence needed to expand VVC use and the services using VVC, and will provide critical data on how best to do so. It directly addresses priorities to modernize VA.

PI_NAMEs: LINDSAY, JAN ALEXANDRA (contact)

PROJECT_TERMS: Acceleration;Address;Adherence;Adoption;Affect;Ambulatory Care Facilities;Annual Reports;antiretroviral therapy;Appointment;Area;behavioral health;Biometry;Blood Pressure;care systems;Caring;Chronic;Chronic Disease;Clinic;Clinic Visits;Clinical;Clinical effectiveness;Communicable Diseases;Communities;Complex;Computer software;Computers;Data;Development;Devices;Diagnosis;Effectiveness;effectiveness evaluation;effectiveness trial;effectiveness/implementation study;encryption;Enrollment;Equitable healthcare;Evaluation;evidence base;experience;falls;formative assessment;Fostering;Funding;glucose monitor;handheld mobile device;Health;health care delivery;health disparity;Health Services Accessibility;Healthcare;heart rate monitor;Hepatitis;high risk;HIV;HIV diagnosis;HIV Infections;Home;Hospitals;Hybrids;implementation efforts;implementation evaluation;implementation facilitation;implementation strategy;Improve Access;improved;innovation;Intervention;Interview;Knowledge;Leadership;Location;Logistics;Measures;Medical;Medical center;medical specialties;Medicine;Mental Health;Mental Health Services;Methodology;Methods;mHealth;Modeling;Modernization;Monitor;multidisciplinary;organizational readiness;Outcome;Participant;Patients;Peripheral;Persons;Phase;Physiologic pulse;Primary Care;primary outcome;Privatization;Process;programs;Provider;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;remote location;Research;routine care;Rural;Rural Health;Safety;secondary outcome;Secure;Services;social stigma;Social Work;Stethoscopes;Technology;telehealth;telehealthcare;Telemedicine;Testing;Time;Training;transmission process;Travel;United States;uptake;Veterans;Videoconferencing;Viral;Virus Diseases;Visit;Weight;wireless fidelity;Work

PROJECT_TITLE: VA Video Connect to Improve Access to Multi-disciplinary Specialty Care

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Largely due to intersecting forms of stigma and unmet needs for gender affirmation, transgender and nonbinary people have significantly worse mental health outcomes, compared to the general population. Peers have been identified as a critical aspect of gender affirmation, with peer-delivered interventions offering a promising scalable mechanism for addressing mental health disparities. This proposal aims to leverage a community-engaged approach to identify desired elements of peer support interventions, and to develop and test an intervention to improve mental health outcomes among transgender and nonbinary people.

PI_NAMEs: STROUMSA, DAPHNA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Affect;AIDS prevention;Anxiety;Award;Behavior Therapy;behavioral clinical trial;burden of illness;career;career development;Caring;Chronic;Clinic;Clinical;Clinical Trials;Collaborations;Communities;community based participatory research;community collaboration;community engaged approach;community engaged research;Conduct Clinical Trials;Data;design;Development;Development Plans;disparity reduction;Educational workshop;effective intervention;Elements;Emotional;Evaluation;experience;feasibility testing;Feedback;Funding;Gender;gender affirmation;gender affirming care;gender affirming hormones;Gender Identity;gender minority;General Population;Goals;Gynecologist;Health;health care availability;health disparity;health equity;Health Services;Healthcare;Healthcare Systems;improved;Individual;Intervention;intervention refinement;Interview;Knowledge;Lived experience;marginalized population;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentors;Methods;Michigan;minority stress;nonbinary;Outcome;Pathway interactions;patient oriented;Patients;peer;peer support;Personal Satisfaction;Persons;Phase;Physicians;pilot test;Population;preventive intervention;Process;Production;programs;Property;Provider;racial identity;recruit;Reduce health disparities;Research;Research Personnel;Research Training;Respondent;Risk Reduction;Role;Safety;service programs;Sexual and Gender Minorities;Site;skills;social stigma;social stress;Specialist;Stress;stressor;Structure;suicidal;suicidal risk;Suicide attempt;Target Populations;Testing;therapy design;Training;transgender;United States;United States National Institutes of Health;Universities;Validation;Work

PROJECT_TITLE: Peer specialist intervention to reduce disparities in the mental health of  transgender and nonbinary individuals


ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: NARRATIVE STATEMENT These studies are relevant to public health because despite considerable progress in our understanding of prostate cancer biology, prostate cancer remains a significant cause of suffering and the second leading cause of cancer death among men and there is a pressing need for new and better approaches to treatment. The remarkably adaptive nature and complexity of prostate cancer progression and the uniform development of resistance underscores the importance of developing a broader range of therapeutic agents and approaches that would increase chances of overcoming the resistance to current therapies. This proposal focuses on elucidating how a novel small molecule therapeutic agent may be used to treat prostate cancer by regulating a novel target and an under-exploited cellular process in cancer cells.

PI_NAMEs: KIM, FELIX JINHYUN (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: abiraterone;Address;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;antitumor effect;Automobile Driving;Autophagocytosis;Bioenergetics;Biological Availability;Cancer Biology;cancer cell;Cancer Cell Growth;Cancer Etiology;Catabolism;cell growth regulation;Cell Line;Cell Physiology;Cessation of life;Cholesterol;Clinical;cohort;Combined Modality Therapy;deprivation;design;Disease;enzalutamide;fatty acid oxidation;Fatty Acids;Feedback;FRAP1 gene;Genotype;Growth;Heterogeneity;Homeostasis;improved;In Vitro;in vitro Model;in vivo;inhibitor;lipid biosynthesis;lipid metabolism;lipidomics;Lipids;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Mediator;men;Metabolic;Metabolism;Metastatic Prostate Cancer;Mitochondria;Modeling;Nature;Normal Cell;novel;novel strategies;novel therapeutic intervention;Oncogenic;Oral;Organoids;Pathway interactions;patient derived xenograft model;Phase;Phenotype;PI3K/AKT;PIK3CG gene;Play;Proliferating;prostate cancer cell;prostate cancer model;prostate cancer progression;Prostate Cancer therapy;Protein Biosynthesis;protein metabolism;Proteins;proteostasis;Public Health;receptor;Receptor Cross-Talk;Receptor Signaling;Refractory;Regulation;Resistance;Resistance development;resistance mechanism;Role;Scaffolding Protein;Series;Signal Pathway;Signal Transduction;small molecule inhibitor;small molecule therapeutics;standard of care;targeted agent;targeted treatment;Technology;Therapeutic Agents;Toxic effect;treatment strategy;tumor;tumor growth;tumor metabolism;Up-Regulation;uptake

PROJECT_TITLE: Multifunctional Regulation of Prostate Cancer Metabolism by Sigma1 Modulators

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Social Determinants of Health;Violence Research

PHR: PROJECT NARRATIVE The utilization trends of mental health services among transgender (TG) people are poorly understood due to the limited sample sizes, yet there are increased efforts to identify TG people within large electronic health care data using computational phenotypes (CPs). Through this proposed research and training plan, the applicant will investigate the performance of existing CPs to assess the health care utilization trends of TG patients with depressive disorders (DD), anxiety, and attention deficit disorders (ADD) and their risk of self-harm. Ultimately, the results of this work can inform future mental health care policy and public health officials to inform interventions and improve mental health equity among this understudied population.

PI_NAMEs: BELTRAN, THEO  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Address;Adherence;Adopted;Algorithms;American;antiretroviral therapy;Anxiety;Attention Deficit Disorder;billing data;Birth;career;Caring;Chronic Disease;cisgender;clinical epidemiology;clinically actionable;Code;Communication;Computerized Medical Record;Data;Data Sources;Databases;Decision Making;Depressive disorder;Diagnosis;Diagnostic;Discrimination;Disease;Disparity population;Drug Prescriptions;Effectiveness;eHealth;electronic medical record system;Epidemiology;epidemiology study;Evaluation;experience;Faculty;Future;gender affirming care;Gender Identity;General Population;Goals;Guidelines;health assessment;health care service utilization;health disparity;health equity;Health equity research;health inequalities;Health Policy;Health trends;Healthcare;High Prevalence;high risk;HIV;improved;Individual;Inpatients;insurance claims;Intervention;Knowledge;large datasets;longitudinal analysis;Managed Care;Measures;Medical;medication compliance;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methods;Modeling;Monitor;Outcome;Outpatients;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacologic Substance;Phase;Phenotype;phenotyping algorithm;Policies;Population;Prevalence;Privatization;Probability;Procedures;Psychiatric Diagnosis;Psychiatric therapeutic procedure;Psychologist;Psychotherapy;Public Health;Recommendation;Records;Reporting;Research;Research Personnel;Risk;Role;Sample Size;Self-Injurious Behavior;Services;sex assigned;skills;social;social group;study population;Suicide attempt;Time;Time trend;Training;transgender;transgender women;Translating;treatment duration;trend;United States;Victimization;Violence;Visit;Vulnerable Populations;Weight;Work

PROJECT_TITLE: Applying Computational Phenotypes To Assess Mental Health Disorders Among Transgender Patients in the United States

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-D(20)L]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Lung;Orphan Drug;Patient Safety;Precision Medicine;Pulmonary Fibrosis;Rare Diseases

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative We will perform a genotype-driven trial assessing the efficacy of NAC in patients with TOLLIP rs3750920 T/T genotype. We will also molecularly endophenotype all patients with IPF and ILD in the PFF biospecimen repository using whole genome sequencing, RNA sequencing and proteomics.

PI_NAMEs: FLAHERTY, KEVIN R;SPINO, CATHERINE A (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acetylcysteine;Achievement;Adherence;Adverse event;antifibrotic treatment;archived data;biobank;Biological;Biological Specimen Banks;Biomedical Research;Biometry;Budgets;Case Report Form;Characteristics;Clinical;clinical care;Clinical Data;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Collection;Communication;Consent;Custom;Data;Data Collection;Data Coordinating Center;data management;Data Set;database design;Databases;design;Diagnosis;Diagnostic;disease heterogeneity;Documentation;education research;efficacy evaluation;endophenotype;Ensure;Esapent;experience;Faculty;fibrotic interstitial lung disease;Fostering;Foundations;Genetic;genetic variant;genome sequencing;Genotype;Goals;idiopathic pulmonary fibrosis;Information Dissemination;Infrastructure;Interstitial Lung Diseases;Leadership;Lung;meetings;Methodology;Michigan;Molecular;Molecular Analysis;Monitor;multimodal data;National Heart, Lung, and Blood Institute;novel;Online Systems;operation;Outcome;Pathogenesis;patient registry;Patients;personalized approach;Pharmacogenomics;Phenotype;Play;precision medicine;Procedures;Process;Productivity;Prognosis;programs;prospective;Proteomics;Protocols documentation;Provider;Pulmonary Fibrosis;Qualifying;Recontacts;Recording of previous events;recruit;Registries;Reporting;Reproducibility;Reproducibility of Results;Research;Research Design;Research Personnel;Risk;Role;Safety;Sample Size;Sampling;Science;Secure;Services;Site;Slide;Statistical Data Interpretation;Statistical Methods;success;System;Teleconferences;Telephone Interviews;Testing;Time;timeline;TOLLIP gene;tool;Training;transcriptome sequencing;Treatment Efficacy;United States National Institutes of Health;Universities;Visit;web site;webinar;whole genome

PROJECT_TITLE: Prospective tReatment EffiCacy in IPF uSlng genOtype for Nac Selection (PRECISIONS) trial and Molecular Endophenotyping in Idiopathic Pulmonary Fibrosis and Interstitial Lung Diseases study

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The proposed project will investigate at a very detailed level the origin of interictal spikes, one of the key electrical outputs of an epileptic brain. We have developed a system for recording and manipulating activity in individual neurons spanning an entire epileptic brain slice. This system will be used to identify the cell types involved in generating interictal spikes and the mechanisms by which they synchronize, both of which will directly inform development of novel antiepileptic therapies.

PI_NAMEs: LILLIS, KYLE PATRICK (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TITLE: Mechanisms of Interictal Spike Generation

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Clonal mosaicism in the blood has not been comprehensively investigated in African American and Latino populations. We will assess this biomarker of cancer risk in these populations through the development of novel methodology that will enhance integrative analysis of mosaic mutations, germline variation, and ancestry. A better understanding of mosaicism in these under-studied populations will allow for more targeted cancer risk assessment and early detection.

PI_NAMEs: JAKUBEK SWARTZLANDER, YASMINKA ALEKSANDRA (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Address;Admixture;admixture mapping;African;African American;African American population;African ancestry;American;ancestry analysis;Blood;cancer biomarkers;cancer genomics;cancer prevention;cancer risk;cancer seeding;career;Cell Fraction;Cells;Cessation of life;Clonal Expansion;Complement;Computing Methodologies;Data;Data Set;detection method;Development;Disease;DNA Sequence Alteration;Early Diagnosis;Ensure;European;European ancestry;follow-up;Frequencies;Funding;Genes;Genetic;Genetic Population Study;Genetic study;genetic variant;Genetic Variation;genome sequencing;genome wide association study;Genomic Segment;genomic variation;Genomics;Germ Lines;Goals;Grant;Haplotypes;Hematologic Neoplasms;Hematology;high risk;Human;improved;Incidence;Individual;Inherited;innovation;insight;Japanese;Japanese Population;Joints;K22 Award;Latino;Latino Population;leukemia;Link;Loss of Heterozygosity;Malignant Neoplasms;Maps;Mentors;method development;Methodology;Methods;Minority Groups;Modeling;Molecular;Molecular Profiling;mosaic;mosaic analysis;mosaic variant;Mosaicism;multi-ethnic;Mutation;Non-Malignant;Normal tissue morphology;novel;Organism;Paint;Pathologic;Pattern;Persons;Point Mutation;Population;Population Genetics;premalignant;Prevention;Prevention strategy;Prognosis;programs;Proliferating;Publications;Recurrence;Reporting;Research;Research Personnel;Risk Assessment;Sampling;Screening for cancer;Single Nucleotide Polymorphism;skills;Statistical Methods;Testing;Tissues;Training;translational applications;translational potential;Translations;Underrepresented Populations;Variant;variant detection;whole genome;Work;Writing;zygote

PROJECT_TITLE: Admixture mapping of mosaic copy number alterations for identification of cancer drivers


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Machine Learning and Artificial Intelligence

ORG_DEPT: PHYSICS

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative In spite of the dramatic increase in our understanding of the structure and properties of hepatitis B virus (HBV), this pathogen remains a major threat to human health. That knowledge also makes HBV an important test case for new antiviral strategies. This project aims to limit the impact of HBV by using computer simulations and synthetic chemistry to develop an improved understanding of the assembly process of HBV as well as new drugs that can eliminate HBV infection in ways that may be generalized to other pathogenic viruses.

PI_NAMEs: GUMBART, JAMES C. (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Address;Affect;Anti-viral Agents;Binding;Biological Assay;Capsid;Capsid Proteins;Cells;Cessation of life;Chronic Hepatitis B;Cirrhosis;Classification Scheme;clinically relevant;Complex;Computer Simulation;Coupled;Cryoelectron Microscopy;Development;dimer;DNA biosynthesis;Docking;drug development;Encapsulated;Equilibrium;experimental study;Failure;Free Energy;Goals;Health;Hepatitis B Virus;HIV-1;Human;Image;improved;In Vitro;Infection;intermolecular interaction;Intervention;Knowledge;Laboratories;Lead;lead optimization;Liver;machine learning classification;Malignant Neoplasms;Methods;Modification;Molecular Conformation;molecular dynamics;Morbidity - disease rate;mortality;novel;novel therapeutics;Outcome;pathogen;pathogenic virus;Pathway interactions;Persons;pharmacologic;Procedures;Process;programs;Property;Protein Conformation;Protein Dynamics;Protein Inhibition;protein oligomer;protein protein interaction;protein structure;Proteins;rational design;Rationalization;Resistance;Reverse Transcription;Sampling;simulation;small molecule;Structure;success;Synthesis Chemistry;Testing;Toxic effect;United States;Viral;Viral Genome;viral genomics;Viral Physiology;Virus;Virus Assembly;Virus Diseases

PROJECT_TITLE: Altering Hepatitis B Virus assembly through pharmacological intervention

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The goal of this MIRA research proposal is to re-innovate recombinant microRNA technology and utilize novel tools to dissect posttranscriptional regulation mechanisms in cellular xenobiotic metabolism and disposition, and establish the impact on pharmacokinetics and pharmacodynamics. These studies will answer key questions related to the robustness and utilities of novel recombinant RNA molecules in deciphering new miRNA regulatory mechanisms and improving therapeutic outcomes.

PI_NAMEs: YU, AIMING  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Animal Model;Area;Biomedical Engineering;Body System;Cells;Chemicals;cost effective;drug development;drug disposition;drug metabolism;Drug Modulation;Engineering;Enzymes;Fermentation;Gene Expression;Goals;Hepatocyte;Human;Hybrids;improved;In Vitro;in vivo Model;innovation;Laboratories;large scale production;Medical;MicroRNAs;milligram;Modification;Molecular;novel;pharmacokinetics and pharmacodynamics;Pharmacotherapy;polypeptide;Post-Transcriptional Regulation;posttranscriptional;Process;Prodrugs;Production;Proteins;recombinant RNA;Recombinants;Research;research and development;Research Proposals;RNA;Science;Small Interfering RNA;success;Technology;therapy outcome;tool;Transfer RNA;Untranslated RNA;Xenobiotic Metabolism

PROJECT_TITLE: Recombinant microRNAs in xenobiotic metabolism and disposition

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

PHR: Shigella species are the causative agents of bacillary dysentery, a severe form of diarrhea that infects millions of people each year and causes hundreds of thousands of deaths. This bacterium invades and grows within intestinal epithelial cells by disarming the host’s innate immune responses. Here, by investigating how the bacteria evade host responses, we will gain critical knowledge regarding new potential ways to interrupt the infection process.

PI_NAMEs: LESSER, CAMMIE  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Actins;Acute;Antibiotic Resistance;Bacteria;Binding;Binding Proteins;CASP1 gene;CASP4 gene;CASP5 gene;Caspase;Cell Death;Cell membrane;Cell Physiology;Cells;Cessation of life;Collaborations;Colon;Complex;cytokine;Cytolysis;Cytosol;Data;design;Development;Diarrhea;enteric infection;enteric pathogen;Environment;Epithelial Cells;Epithelium;Face;Future;gain of function;Gastrointestinal tract structure;GBP1 gene;Goals;Growth;guanylate;gut inflammation;Host Defense;Human;human pathogen;IL18 gene;Immune response;improved;Infection;Infection prevention;Inflammasome;Inflammation;Inflammatory;Innate Immune Response;innovation;interest;Interferons;Interleukin-1 beta;Interruption;Intervention;intestinal epithelium;Invaded;Ions;Knowledge;Learning;Lipid A;Lipopolysaccharides;Mediating;Modeling;Modification;Motility;Mus;N-terminal;neutrophil;Neutrophil Infiltration;novel;Oral;Orthologous Gene;OspC protein;pathogen;Pathogenesis;pathogenic bacteria;Peptide Hydrolases;Persons;Prevention;Process;Proteins;recruit;Regulation;Research;Role;sensor;Shigella;Shigella Infections;Specificity;Swelling;Testing;Tissues;Type III Secretion System Pathway;Ubiquitin;Variant;Work

PROJECT_TITLE: Shigella mediated regulation of epithelial cell inflammasomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-J(90)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Histoplasma capsulatum is a primary pathogen that infects approximately 500,000 individuals per year in the U.S., and is a significant source of morbidity and mortality. The identification and characterization of regulatory pathways that influence cell shape and pathogenesis will significantly advance our understanding of how this organism responds to host signals such as tempererature to cause disease.

PI_NAMEs: SIL, ANITA  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Affect;Body Temperature;Cell Shape;Cell surface;cell type;Cells;cold temperature;Coupled;CRISPR/Cas technology;Cystine;Data;Data Set;differential expression;Disease;Elements;Environment;experimental study;Funding;fungus;gene discovery;Gene Expression;Gene Expression Profiling;Genes;genetic approach;Genetic Transcription;Goals;Growth;High temperature of physical object;Histoplasma;Histoplasma capsulatum;Human;human pathogen;Hyphae;Individual;Infection;Inhalation;Laboratories;Link;Macrophage;Mammals;member;Membrane;Modeling;Molds;Molecular;Molecular Genetics;Morbidity - disease rate;Morphology;mortality;Mucins;Mus;mutant;Mutation;novel;Organism;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Phase;Post-Transcriptional Regulation;posttranscriptional;programs;Protein Family;Proteins;Publishing;Regulation;Regulation of Cell Shape;Regulatory Pathway;Regulon;Repression;Research;Respiratory Tract Infections;response;Ribosomal RNA;ribosome profiling;Role;Signal Transduction;Soil;Source;Temperature;Temperature Sense;trait;Transcript;transcription factor;transcriptome sequencing;Translations;Virulence;Virulence Factors;virulence gene;Work;Yeasts

PROJECT_TITLE: Gene circuits that control morphology in Histoplasma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Urologic Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: The most common cause of multi-drug resistant urinary tract infections (UTIs) are two Escherichia coli strains, that at the same time appears to be able persisting for a long time in the gut and bladder of healthy women, without symptoms of UTI or taking antibiotics. The objective of the proposed work is to investigate in detail the frequency of gut and bladder carriage by these two strains, identify possible means of the carriers de-colonization and compare on a genome-wide scale the E. coli strains from women without and with UTI.

PI_NAMEs: SOKURENKO, EVGENI VENIAMINOVIC (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: antagonist;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Area;Bacteremia;Bacterial Infections;bacterial resistance;Bacteriophages;Bacteriuria;Bladder;Clinical;clinical risk;Clonality;cohort;Collection;Communities;Data;Data Analyses;Ecology;enteric infection;Epidemiology;Escherichia coli;Escherichia coli drug resistance;expectation;Family;fluoroquinolone resistance;Fluoroquinolones;Frequencies;Funding;Gene Transfer;General Population;Genetic Transcription;Genetic Variation;genome-wide;Genomics;Goals;Health Personnel;Horizontal Gene Transfer;Human;human pathogen;Infection;insertion/deletion mutation;Integration Host Factors;Medicine;member;Molecular;Multi-Drug Resistance;Mutation;new pandemic;nosocomial UTI;novel;pandemic disease;Pathogenicity;Patients;Pattern;Population;Productivity;Prophylactic treatment;Public Health;Publishing;Recommendation;Research;resistant strain;Risk;Risk Reduction;Sampling;Single Nucleotide Polymorphism;sound;stool sample;Symptoms;Testing;Therapeutic;Time;Urinary tract;Urinary tract infection;Urine;Uropathogenic E. coli;urovirulent isolates;Vaccines;Virulence;Washington;Woman;Work

PROJECT_TITLE: Molecular Clonality of Uropathogenic E. Coli

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-U(02)M]


ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Identifying cellular reservoirs contributing to HIV-1 persistence is essential for development of curative strategies for HIV-1. This application is based on the central hypothesis that brain pericytes are a key, albeit previously unrecognized, cell type for the formation of HIV-1 reservoirs in the CNS. The proposed experiment will define whether brain pericytes harbor latent HIV-1 infections in HIV-suppressed patients (Aim 1), evaluate transcriptional signatures of latently HIV-1-infected human brain pericytes (Aim 2), and determine functional outcomes associated with HIV-1 infection of brain pericytes (Aim 3). Overall, the obtained results will help us to better characterize the pericyte reservoirs in the CNS in order to design future therapies for reservoir clearance and HIV-1 cure.

PI_NAMEs: TOBOREK, MICHAL  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Acute;Address;Astrocytes;Attention;Biology;Blood - brain barrier anatomy;Brain;brain pericytes;cell type;Cells;cerebrovascular;Cerebrovascular Disorders;Chronic;cohort;comorbidity;Coupling;Data;Dendritic Cells;design;Development;DNA;Endothelial Cells;experimental study;Functional disorder;functional outcomes;Future;Gap Junctions;Gene Expression Profile;Goals;Growth;high risk;HIV;HIV encephalitis;HIV Infections;HIV-1;HIV/AIDS;Homeostasis;Human;immune activation;Immune system;Immunohistochemistry;Impairment;In Situ Hybridization;in situ imaging;In Vitro;in vivo;Individual;Infection;Inflammation;innovation;Knowledge;latent infection;Latent virus infection phase;Life Cycle Stages;Macrophage;Metabolic;Methods;Microglia;monocyte;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;Names;National NeuroAids Tissue Consortium;Nervous System Disorder;neuroAIDS;Neurocognitive;Neurologic;neuropathology;neurovascular;neurovascular unit;novel;Pathogenesis;Pathology;Patients;Pericytes;pharmacologic;Population;Predisposition;Productivity;Proviruses;Publishing;receptor;Recording of previous events;Reporter;Research;RNA;Role;Sampling;sensor;Signal Transduction;Sorting;transcriptome;transmission process;Viral;Viral reservoir;Virus;Virus Replication;Work

PROJECT_TITLE: Defining brain pericytes as a novel and myeloid-derived HIV reservoir


PHR: Narrative The Rieske non-heme iron oxygenases are broadly represented in Nature and showcase reactivity that is essential for degrading environmental pollutants and building medically relevant and commercially valuable natural products. Despite the wealth of annotated Rieske oxygenases, there is a critical lack of information about how these enzymes employ a common set of metallocenters to catalyze a diverse set of site-specific oxygenation reactions. It is therefore critical to obtain information about the structure–function relationships in this class of enzymes to facilitate efforts aimed at repurposing and redesigning Rieske oxygenases for industrial use.

PI_NAMEs: BRIDWELL-RABB, JENNIFER D (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: One, Two, and Three Rieske Routes for Catalyzing Site-Specific Oxygenations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

PHR: Narrative. Uterine fibroids (UF) are a highly common and costly gynecologic condition that disproportionately affect Black women with regard to incidence, severity, treatment, and outcomes. Recent data suggest that substantial Black/White disparities in UF exist within VA. As one-third of women Veterans using VA health care are Black and this proportion is increasing, understanding the drivers of these disparities within VA is of critical importance. This study will use mixed methods to investigate mechanisms underlying Black/White disparities in UF-related outcomes in VA, including modifiable differences by race in pathways to treatment and interactions with the healthcare system. This work addresses multiple HSR&D priority areas including women’s health, health equity, and healthcare access and will make a substantial impact by informing development of patient-centered interventions to eliminate disparities. Next steps will include partnering with VA women’s health and health equity leaders to design programs and policies that can accelerate progress towards quality and equity in gynecology care in VA.

PI_NAMEs: CALLEGARI, LISA SUSANNE;KATON, JODIE  (contact)

PROJECT_TERMS: Abdomen;Acceleration;Accounting;Address;Affect;Age;Anemia;Area;Behavior;black patient;Black Populations;Black race;black women;black/white disparity;Blood Transfusion;care seeking;Caring;Clinical;clinical care;clinical decision-making;cohort;Cohort Analysis;common treatment;Complex;cost;Data;data warehouse;debilitating symptom;Decision Making;design;Development;Diagnosis;Disparity;disparity elimination;disparity reduction;Disproportionately impacts women;Emergency department visit;Ensure;Equity;ethnic disparity;experience;fertility preservation;Fibroid Tumor;Future;Gender;Goals;Gynecologic;Gynecology;health care availability;health care model;Health Care Research;health equity;Healthcare;Healthcare Systems;Hemorrhage;hospital readmission;Hospitalization;Hysterectomy;Incidence;innovation;Intervention;Medical;Medical Records;Methods;minimally invasive;Newly Diagnosed;Non-Malignant;Operative Surgical Procedures;Outcome;Pain;Pathway interactions;patient oriented;Patient Preferences;Pattern;Pelvis;Policies;policy recommendation;preference;pressure;Procedures;Process;programs;Provider;Public Health;Race;racial difference;racial disparity;racial health disparity;racism;Recovery;Reproduction;Reproductive Health;Research;Research Personnel;Research Priority;Retrospective cohort;Role;Sampling;Severities;Shapes;social;Social Environment;Structure;surgery outcome;Surgical complication;surgical risk;Symptoms;therapy development;Time;Translating;treatment and outcome;treatment disparity;treatment pattern;Uterine Fibroids;Uterine Neoplasms;Veterans;White Women;Woman;women's diagnosis;Women's Health;Women's Health Services;women's outcomes;Work

PROJECT_TITLE: Understanding Racial/Ethnic Disparities in Uterine Fibroid Outcomes among Women Veterans: A mixed-methods study

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Public Health Relevance Statement: It is critical to understand normal activity of stem cells in order to understand how mis-regulation of their normal function leads to various human diseases and how to apply them in regenerative medicine. Our research will address the epigenetic regulation of stem cell maintenance, proliferation and differentiation using the Drosophila male germline stem cell lineage as a model system.

PI_NAMEs: CHEN, XIN  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: adult stem cell;Area;Biochemical;Biological;Biological Models;Biology;Biophysics;Cancer Biology;Cell Culture System;Cell Cycle Progression;Cell Differentiation process;Cell Lineage;Cell Maintenance;Cells;Cellular biology;ChIP-seq;Chromatin;Chromatin Fiber;Complex;Data;Diabetes Mellitus;dimer;Disease;DNA;DNA biosynthesis;DNA fiber assay;DNA replication fork;DNA Sequence;Drosophila genus;Epigenetic Process;epigenetic regulation;Event;experimental study;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Transcription;Genomic DNA;genomic locus;Genomic Segment;Genomics;Germ Cells;Germ Lines;germline stem cells;histone modification;Histones;human disease;In Vitro;in vivo;Infertility;Label;male;Malignant Neoplasms;Mammals;Maps;Methods;Molecular;Molecular Biology;Molecular Genetics;Movement;Muscular Dystrophies;Nerve Degeneration;novel;Okazaki fragments;origin recognition complex;Phase;Play;Polycomb;programs;Proliferating;Proliferating Cell Nuclear Antigen;Proteins;public health relevance;Regenerative Medicine;Replication Initiation;Replication Origin;Reproductive Biology;Research;Research Personnel;RNA;Role;S phase;self-renewal;Series;Somatic Cell;Spermatocytes;stem cell biology;stem cell function;stem cell population;stem cell proliferation;stem cells;stemness;Structure;System;Testing;Therapeutic;tissue degeneration;transcriptome;transcriptome sequencing;Work

PROJECT_TITLE: Epigenetic Regulation of Germ Cell Differentiation from a Stem Cell Lineage

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MADISON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project narrative Amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease is characterized by the specific death of the nerve cells that control muscle movement, leading to paralysis and eventual death. ALS is linked to inflammation and defects in energy metabolism. This proposal will investigate if altered expression of a protein that binds fatty acids and regulates inflammation and metabolism plays a role in the progression of the disease in ALS-models.

PI_NAMEs: VARGAS, MARCELO R (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Adult;Affect;Affinity;ALS pathology;ALS patients;Amyotrophic Lateral Sclerosis;Astrocytes;Autopsy;Binding;Binding Proteins;Biology;Brain;Brain Stem;Cause of Death;Cell Culture Techniques;Cell Physiology;Cells;Cellular Metabolic Process;Central Nervous System;Cessation of life;Coculture Techniques;Cytoplasmic Granules;Data;Defect;Development;Disease;Disease Progression;DNA Sequence Alteration;dominant genetic mutation;Down-Regulation;effective therapy;Energy Metabolism;Energy-Generating Resources;Environmental Exposure;Exhibits;experimental study;familial amyotrophic lateral sclerosis;Family;fatty acid metabolism;fatty acid-binding proteins;Fatty Acids;Functional disorder;Gene Expression;Genetic Transcription;Goals;Growth;Health;Homeostasis;In Vitro;in vivo;in vivo Model;Individual;Induced Neurons;induced pluripotent stem cell;Inflammation;Inflammatory;Inflammatory Response;insight;Knock-out;Ligand Binding;Ligands;Link;Lipid Binding;lipid metabolism;Lipid Peroxidation;Lipids;long chain fatty acid;Mediating;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Molecular Chaperones;Motor Cortex;motor neuron degeneration;Motor Neurons;mouse model;Movement;Mus;Muscle;Muscle Weakness;Nerve Degeneration;nerve stem cell;Neuroglia;neuroinflammation;neuron loss;neurotoxic;NF-kappa B;novel therapeutic intervention;Nuclear Receptors;Oxidative Stress;Paralysed;Pathogenicity;Pathologic;Pathway interactions;Patients;Peroxisome Proliferator-Activated Receptors;Pharmaceutical Preparations;Phenotype;phenylmethylpyrazolone;prevent;Process;Proteins;Publishing;Radial;Receptor Activation;Recording of previous events;response;Rest;Riluzole;Role;Shapes;Signal Transduction;Signaling Molecule;Spinal Cord;sporadic amyotrophic lateral sclerosis;Symptoms;Therapeutic;therapeutic target;Time;transcription factor;United States;Up-Regulation;uptake

PROJECT_TITLE: Role of FABP7 in ALS models

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative This proposal is for a mentored K08 award for a physician who treats patients with post-surgical lymphedema and is training to become an independent researcher. This proposal aims to study the spontaneous physiological resolution of lymphedema via lymphovenous shunts and lymphangiogenesis. Tissue nanotransfection technology is used as innovative approach for focal gene delivery topically directly to the lymphedema site.

PI_NAMEs: HASSANEIN, ALADDIN HASAN (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Adipose tissue;Adopted;Affect;American;Animal Model;Area;arm;Award;Axilla;Breast Cancer Patient;Breast Melanoma;Bypass;C-Type Lectins;Cancer Survivor;career development;Chronic;Circulation;Clinical;clinical application;Clinical Research;Consumption;Dedications;Deformity;Deposition;Development;Disease;Down-Regulation;electric field;Equipment;Excision;Exhibits;experience;experimental study;Fibrosis;Foundations;Funding;Gene Delivery;Gene Transfer;Genes;Genetic;Goals;Grant;Human;Iatrogenesis;iatrogenic injury;improved;in vivo;Indiana;Infection;injured;Injury;innovation;insight;Institution;Intercellular Fluid;Junior Physician;Laboratories;Lead;Limb structure;Liquid substance;Lymph;Lymph Node Dissections;lymph nodes;Lymphangiogenesis;Lymphatic;lymphatic dysfunction;Lymphatic function;Lymphatic System;lymphatic vessel;Lymphedema;Malignant Breast Neoplasm;Malignant Neoplasms;Master of Science;medical schools;Mentors;Mentorship;Microsurgery;Modeling;Morbidity - disease rate;mouse model;Mus;nanochannel;Nanotechnology;nanotransfection;novel;novel strategies;Oncology;operation;Operative Surgical Procedures;Pain;Pathway interactions;Patients;Persons;physical therapist;Physical therapy;Physicians;Physiological;Plasmids;PLCG2 gene;Postoperative Period;Procedures;Process;professor;programs;receptor;recurrent infection;Research;Research Personnel;Resolution;Scientist;Secondary to;Shunt Device;Signaling Molecule;Site;Surgical Management;Swelling;Tail;Technology;Testing;Time;Tissues;Topical application;Training;Translational Research;Universities;Vascularization;vector;Veins;Venous;Venous system;Viral Vector;Virus;Work

PROJECT_TITLE: Novel Mechanisms in the Resolution of Post-Surgical Lymphedema

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE The 9-1-1 complexes are an essential component of the DNA damage response pathway by acting as a sensor of damaged sites to promote the direct recruitment of DNA repair proteins and activate ATR signaling. Despite the advancement in understanding the ATR signaling network during meiosis, it remains unclear the role of the 9-1-1 complexes in ATR signaling regulation. Understanding the 9-1-1 mediated ATR signaling will improve our knowledge of the molecular mechanisms regulated by ATR that allow high-fidelity gamete production.

PI_NAMEs: ARROYO MARTINEZ, GERARDO ANTONIO (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Alanine;Biological Process;C-terminal;Cell Cycle Regulation;Cell Physiology;Chromosome Pairing;Chromosome Structures;Chromosomes;Closure by clamp;Complex;conditional knockout;CSPG6 gene;Data;Defect;disability;disabled;DNA Damage;DNA Repair;DNA Repair Gene;Double Strand Break Repair;Embryo;Evaluation;Event;experimental study;Fertility;Fostering;Gametogenesis;Genetic Crossing Over;Genome;Genome Stability;Genomic Instability;Germ Cells;Haploidy;Histologic;Homologous Gene;homologous recombination;Human;Impairment;improved;Infertility;inhibitor;Knockout Mice;Knowledge;Maintenance;Mediating;Meiosis;Meiotic Prophase I;Modeling;Molecular;Mus;mutant;Mutant Strains Mice;Mutation;novel;null mutation;paralogous gene;Pathway interactions;Phenotype;phosphoproteomics;Phosphorylation;Phosphotransferases;prevent;Process;Production;RAD9A gene;recruit;Regulation;repaired;Reporting;Reproductive Health;response;Role;segregation;sensor;Serine;SETX gene;Sex Chromosomes;Signal Transduction;Site;Somatic Cell;Spermatocytes;Synapses;Synaptonemal Complex;Tail;Testing;Testis;TOPBP1 Gene

PROJECT_TITLE: ATR signaling activation by the 9-1-1 complexes during mammalian meiosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-L(20)L]


ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative The ability to selectively functionalize C–H bonds enables synthetic access to a wide range of valuable chemical feedstocks for the production of pharmaceuticals, natural products, polymers, and commodity chemicals. A promising strategy to carry out selective hydrocarbon functionalization is to design modular catalysts in which the steric and electronic constraints of the active site impart catalyst-encoded selectivity towards a targeted C– H bond. This work aims to harness the oxidative power of electro- and photochemically generated nitrogen- centered radicals catalysts for selective C–H bond functionalization.

PI_NAMEs: GORDON, JESSE  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TITLE: Catalytically Generated Amidyl Radicals for Site-Selective Intermolecular C-H Functionalization


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The goal of the proposed research is to understand fundamental principles in microbial physiology, focusing on homeostatic control of gene expression and protein content relevant for growth and the cell cycle. Understanding physiological homeostasis is central to growth regulation, and what makes the disease state diﬀerent from normal cells.

PI_NAMEs: JUN, SUCKJOON  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Amino Acids;Bacillus subtilis;Bacteria;Biological;Birth;Cell Aging;Cell Cycle;Cell Size;Cells;Cellular biology;Communities;Democracy;Development;Disease;Ensure;Equilibrium;Escherichia coli;Feedback;Gene Expression;Gene Proteins;Goals;Growth;Homeostasis;interdisciplinary approach;Knowledge;Malignant Neoplasms;Microbial Physiology;microorganism;Modeling;Nature;new technology;Normal Cell;Organelles;Physiological;Physiological Processes;Physiology;Production;programs;Proteins;Regulation;Replication Initiation;Research;Resource Allocation;Resources;success;Technology;Work

PROJECT_TITLE: Control of cellular resource allocation across biological scales in microorganisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ORG_CITY: Nashville

ORG_DEPT: NEUROSCIENCES

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Type IV P-type ATPases (P4-ATPases) are lipid regulators known for their ability to influence membrane composition and vesicular transport within the cell and when its function is disrupted, leads to various neurological diseases. This project will be using Saccharomyces cerevisiae to investigate the role of the flippase activity on the formation of retromer-mediated transport vesicles and their ability to recycling known retromer cargo. The results from this project will elucidate a new form of regulation in intracellular trafficking pathways and allow for an understanding of how absence of P4-ATPases may lead to disease including Alzheimer's and Parkinson's disease.

PI_NAMEs: JIMENEZ, MARIANA DE JESUS (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Alleles;Alzheimer's Disease;Amino Acid Motifs;Apoptosis;ATP Hydrolysis;ATP phosphohydrolase;Back;Binding Sites;Biological;C-terminal;Capsid Proteins;Carrier Proteins;Cell membrane;Cell Physiology;Cells;Charge;Chimeric Proteins;Clathrin;Clathrin-Coated Vesicles;Coat Protein Complex I;Collection;Complex;Cytoplasm;Cytoplasmic Tail;Data;Disease;endosome membrane;Endosomes;Excision;extracellular;Family;Functional disorder;Glucosylceramides;Goals;Golgi Apparatus;Health;Human;Knock-out;late endosome;Lecithin;Length;Life;Link;lipid transport;Lipids;Lysosomes;Mediating;Membrane;Metabolic;Minor;Modeling;Monitor;Morphology;Multivesicular Body;Mutation;N-terminal;Nervous System Disorder;Neurologic;novel;Organelles;Orthologous Gene;Parkinson Disease;Pathway interactions;Pattern;Phosphatidylethanolamine;Phosphatidylserines;Phospholipids;Play;Point Mutation;Process;Property;protein transport;Proteins;Recycling;Regulation;Role;Route;Saccharomyces cerevisiae;Signal Transduction;Sorting;sorting nexins;Sphingolipids;Structure;System;Tail;Temperature;Testing;trafficking;trans-Golgi Network;Transcription Factor AP-1;Travel;Vacuole;Vesicle;vesicle transport;Yeasts

PROJECT_TITLE: Determining the role of retromer and P4-ATPase interactions in cellular functions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT TITLE Subcortical targets involved in the action of psilocybin in learned and innate escape behaviors Project Narrative  Psilocybin represents a potentially revolutionary treatment for depression, a leading cause of disability. However, while preliminary clinical trials are encouraging, knowledge of the mechanisms underlying this effect are less understood and focus predominately on the cortex and hippocampus. This proposal will examine the roles of subcortical brain regions in the action of psilocybin during learned and innate escape behaviors, broadening the approach and understanding for the treatment of depression.

PI_NAMEs: DAVOUDIAN, PASHA A (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Acute;Address;antidepressant effect;Attention;Behavior;Behavioral;Behavioral Paradigm;Biological Assay;Brain;brain control;Brain region;Clinical;clinical effect;Clinical Treatment;Clinical Trials;Data;density;designer receptors exclusively activated by designer drugs;disability;Disease;Dorsal;Dose;early phase clinical trial;Exhibits;experience;experimental study;Genetic;Hallucinogens;Hippocampus;Immediate-Early Genes;in vivo;Innovative Therapy;interest;Knowledge;Learned Helplessness;Learning;Major Depressive Disorder;Maps;Measures;Mediating;Mental Depression;Mood Disorders;Mus;Neocortex;neural;neural circuit;Neurobiology;novel;Patients;Pattern;Physicians;Property;Psilocybin;Psychiatry;Research;Role;Saline;Scientist;Silicon;skills;Stimulus;Structure;Testing;Thalamic structure;Time;tool;Training;Viral;Work


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE microRNA-181b is highly expressed in the vasculature, and has overall, been shown to be beneficial in terms of vascular health. Studies examining the role of microRNA-181b in the vasculature has shown that microRNA- 181b decreases with age with a concurrent rise in vascular stiffness and that induced vascular stiffening has been prevented by increasing levels of microRNA-181b. The purpose of this proposal is to determine the exact mechanism(s) of the age-associated decline in microRNA-181b, discover the unknown downstream targets of microRNA-181b, and measure the effect of microRNA-181b overexpression on vascular health with aging.

PI_NAMEs: TUDAY, ERIC  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Acceleration;Address;Age;age related;age related decline;Aging;aging process;Animal Experimentation;Animal Genetics;Aorta;Appointment;Area;arterial stiffness;Arteries;Atomic Force Microscopy;Award;Biological Assay;Biology of Aging;Biometry;Blood Vessels;Body System;Cardiology;cardiovascular health;Cardiovascular Physiology;Cardiovascular system;career development;Chronic;Chronic Kidney Failure;Cities;cohort;Data;Degradation Pathway;Dementia;design;Development;Development Plans;Dicer Pathway;Doctor of Philosophy;Down-Regulation;Educational process of instructing;EFRAC;Endoribonucleases;Environment;Evaluation;Exposure to;Extramural Activities;Funding;Genetic;Genetic Models;Genetic Transcription;Goals;Health;Heart failure;Homeostasis;in vivo;in vivo Model;Individual;inducible Cre;Inflammatory;Junk DNA;Knock-in;Knock-in Mouse;Laboratories;Measures;member;Methods;MicroRNAs;middle age;Molecular;Molecular Biology;Monocyte Chemoattractant Proteins;Morbidity - disease rate;mortality;mouse model;Mus;NF-kappa B;overexpression;Pathogenesis;Pathologic;Pathologic Processes;Pathway interactions;Physiologic pulse;Physiological;Physiology;Play;Polymerase;premature;preservation;prevent;product development;professor;protein expression;Proteins;Research;Research Project Grants;Resources;RNA Polymerase II;Rodent;Role;screening;Signal Pathway;Smooth Muscle;Smooth Muscle Myocytes;Sodium Chloride;Source;symposium;systolic hypertension;Targeted Research;Therapeutic;Therapeutic Intervention;therapeutically effective;Tissues;TNF gene;Training;Transforming Growth Factor beta;Tumor Necrosis Factor-Beta;Universities;Utah;Vascular Diseases;Vascular Smooth Muscle;Wild Type Mouse;Work

PROJECT_TITLE: The Role of MicroRNA 181b in the Development of Vascular Stiffness with Age

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Biological Aging Study Section[NIA-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: NARRATIVE This project will optimize and automate the Brain Health Registry platform to support online recruitment, screening, assessment, and longitudinal monitoring of older adults. The software will be made available to many outside investigators for use in their own studies. Therefore, the innovative, highly-scalable platform that we will develop will facilitate and accelerate interdisciplinary clinical aging research by many clinicians studying cognitive aging and other neuroscience questions.

PI_NAMEs: NOSHENY, RACHEL LAUREN (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Acceleration;Aging;Alzheimer disease screening;Alzheimer's Disease;Alzheimer’s disease biomarker;Biological Markers;Brain Health Registry;Clinic;Clinical;clinical diagnosis;Clinical Research;Clinical Trials;Cognitive;Cognitive aging;cognitive testing;cohort;Collaborations;Collection;Communication;Communities;Computer software;cost effective;Data;data access;data de-identification;Data Linkages;data registry;Data Set;data sharing;database query;Databases;DNA;Elderly;eligible participant;Enrollment;feasibility testing;Feedback;flexibility;follow-up;Genetic;genetic testing;Goals;Health;health data;Impaired cognition;improved;Information Technology;Infrastructure;innovation;Institutional Review Boards;Internet;Licensing;Life Style;lifestyle data;Link;Manuals;Methods;Modeling;Monitor;Neuropsychological Tests;Neurosciences;novel;Observational Study;older adult;online registry;Participant;participant enrollment;participant retention;patient engagement;Plasma;Process;programs;Questionnaires;recruit;Registries;Reporting;Research;Research Personnel;Resource Sharing;Saliva;Science;screening;Services;Site;software as a service;Surveys;System;technology platform;Testing;therapy development;Time;tool;user-friendly;Validation;validation studies;web site;Work

PROJECT_TITLE: The Brain Health Registry for facilitating interdisciplinary aging research


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Engaging adolescents living with HIV in HIV care is essential for improving HIV outcomes, and depression has been identified as a significant barrier to initiating and remaining in HIV care for this population. The proposed project adapts and enhances an evidence-based mental health intervention protocol and evaluates its role in improving depression and engagement in HIV care in an individual randomized 3-arm pilot among adolescents living with HIV in Malawi. This proposal will generate critical evidence for designing a fully powered clinical trial to test our adapted and enhanced intervention protocols.

PI_NAMEs: BHUSHAN, NIVEDITA L;GAYNES, BRADLEY N (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Address;Adherence;Adolescent;Adolescent Development;adolescent health;adolescent mental health;Adult;Affect;Africa South of the Sahara;Age;antiretroviral therapy;arm;Botswana;care outcomes;Caregivers;Caring;Child;child depression;Chronic Disease;Clinic;Clinical Trials;Counseling;Country;Data;Demographic Factors;Depression screen;depressive symptoms;design;Development;Diagnosis;Effectiveness;evidence base;experience;Focus Groups;follow-up;Friends;Friendships;General Population;Goals;Health;HIV;HIV-infected adolescents;Home;improved;Individual;Infrastructure;innovation;Intervention;Interview;Literature;Malawi;Maps;Measures;Mental Depression;Mental Health;Methods;Modeling;National Institute of Mental Health;Outcome;Participant;peer support;Persons;Pilot Projects;Population;preference;problem solving therapy;Protocols documentation;Provider;Psychosocial Factor;Qualifying;Randomized;Randomized, Controlled Trials;Research;Research Priority;Resource-limited setting;Resources;Role;scale up;skills;Source;standard care;Stigmatization;structural determinants;Testing;Text Messaging;theories;Training;Viral;Work;young adult;Youth;Zimbabwe

PROJECT_TITLE: HIV Engagement and Adolescent Depression Support (HEADS-UP)

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative/Relevance Center for genome imaging (CGI)  A full understanding of the genome will require the highest resolution knowledge of how genes and chromosomes are organized in 3D space in both healthy and diseased cells. Without such knowledge, efforts to advance disease diagnosis and medical intervention will be compromised. As such, the overarching goal of the proposed studies is to develop and implement imaging and analysis strategies that can encompass entire genomes, including the distinction of homologs and the identification of highly repetitive sequences, and, thus, comprehensively elucidate how spatial organiza- tion influences genome function, stability, and inheritance.

PI_NAMEs: WU, CHAO-TING  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;Address;advanced disease;Aneuploidy;Biological;Biological Process;Cells;Chromosome Structures;Chromosomes;Collaborations;Complement;computational pipelines;convolutional neural network;cost;Cues;Data;Data Storage and Retrieval;design;Development;Diagnostic;Diploid Cells;Disease;disease diagnosis;Ensure;Epigenetic Process;epigenome;Etiology;Event;falls;Generations;Genes;Genetic;Genome;genome-wide;Genomic Segment;Genomics;Goals;grasp;Health;Hi-C;Homologous Gene;Human;Human Development;Human Genome;human imaging;Image;Image Analysis;image processing;Imaging Device;imaging study;Individual;Infection;innovation;Intervention;Knowledge;Laboratories;light microscopy;live cell imaging;Malignant Neoplasms;Medical;Methods;Modeling;Molecular Genetics;novel therapeutics;Oligonucleotides;Onset of illness;Physics;Polymers;Predisposition;Repetitive Sequence;Research Personnel;Research Project Grants;Resolution;Resource Sharing;Resources;restraint;senescence;Solid;Sports;Structure;superresolution microscopy;Technology;tool;Training;transcriptome;ultra high resolution;Visualization;whole genome;Work

PROJECT_TITLE: Center for Genome Imaging

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]