NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Children who belong to racial, ethnic, and language minority groups are more likely to die of emergency conditions and, during emergency department visits, are less likely to receive interventions such as antibiotics and pain medication. Such differences in care and outcomes are due, at least in part, to implicit racial bias, yet educational interventions that increase physician awareness of implicit bias are not sufficient to reduce disparities in patient-centered outcomes. This proposal aims to define how implicit bias affects physician behavior in the pediatric emergency department and create a critical foundation for prioritizing behavior change in future bias-reduction intervention research.

PI_NAMEs: GUTMAN, COLLEEN KAYS (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Accident and Emergency department;Address;Affect;Analgesics;Antibiotics;Area;Asthma;Attitude;Award;Awareness;Behavior;behavior change;career development;Caring;Characteristics;Child;Child Care;Child Health;Child Rearing;Code;cognitive load;Communication;communication behavior;Complex;Consensus;Craniocerebral Trauma;Data;Decision Making;Delphi Technique;design;Development;Development Plans;disorder control;disparity reduction;Educational Intervention;effective intervention;Elements;Emergency Care;Emergency Department Physician;Emergency department visit;Emergency Medicine;Emergency Situation;Environment;Equity;Ethnic Origin;experience;Family;Florida;Foundations;Funding;Future;Goals;Head;health communication;Health Disparities Research;health disparity;health literacy;Heart Arrest;high risk;Image;implicit bias;Individual;Inequity;Intervention;Intervention Studies;Interview;Investigation;Judgment;Knowledge;Language;Leadership;Linear Models;marginalization;Measurement;Mediating;Mediation;Mediator;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Minority;minority children;Minority Groups;multidisciplinary;National Center for Advancing Translational Sciences;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;Outcome;outcome disparities;Parents;patient oriented;Patient-Focused Outcomes;Patients;pediatric emergency;Perception;Physicians;Prejudice;professor;prospective;provider behavior;Questionnaires;Race;racial bias;racism;Research;Resources;response;Risk;Science;Scientist;self-reported anxiety;Sepsis;Severity of illness;shared decision making;skills;social factors;Stereotyping;Stress;Uncertainty;unconscious bias;Unconscious State;United States;Universities;Video Recording;Writing

PROJECT_TITLE: Implicit racial bias in pediatric emergency medicine: A foundational investigation of physician behaviors


ADMINISTERING_IC: MD

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PI_NAMEs: WIELAND, MARK L. (contact)

PROJECT_TERMS: Address;Adoption;Adult;adult obesity;American Heart Association;Behavior;behavior influence;bilingualism;Blood Glucose;Blood Pressure;Body mass index;Body Weight decreased;Calories;cardiovascular risk factor;Cholesterol;Chronic Disease;Clinical;cluster randomized design;Communities;community based participatory research;community partnership;Complex;Consumption;COVID-19;design;Development;dietary;Education;efficacy evaluation;efficacy testing;Equity;evidence base;experience;Fasting;Food;Fostering;General Population;Goals;Health;Health behavior change;Health Promotion;health related quality of life;Healthcare Systems;healthy weight;Hispanic;Immigrant;Immigrant community;Immigrant family;Immigration;improved;Infrastructure;innovation;Intervention;Life;Limited English Proficiency;Maintenance;Measures;Mediating;Mediator;member;Mentors;Minnesota;Modeling;Obesity;obesity risk;Outcome;Outcome Measure;Overweight;Participant;Pathway Analysis;Patients;peer;Persons;Physical activity;pilot test;Population;primary outcome;programs;psychosocial outcome;Public Health;Randomized;remote group;Resources;retention rate;sedentary lifestyle;social cohesion;social culture;Social Network;social network intervention;social norm;Social support;sociocultural determinant;Subgroup;success;Surveys;Testing;Time;Training;treatment effect;uptake;virtual;waist circumference;Weight;Work

PROJECT_TITLE: Healthy Immigrant Community: Mobilizing the Power of Social Networks


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Genetic Testing;Genetics;Human Genome;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative Although genetic disorders and birth defects (which may also be genetic) are the leading cause of infant mortality in the United States, many infants die without a confirmed genetic diagnosis, and this limits our ability to fully understand the genomic landscape of infant mortality in order to provide optimal care and to develop approaches to prevent these deaths. This project presents a plan to identify genetic disorders in infants who die to learn more about which genetic conditions are responsible for infant mortality and to evaluate the importance of this information for the infant's family. What we learn from this research will inform the clinical evaluation and management of these tragic losses and will suggest strategies for their prevention.

PI_NAMEs: WOJCIK, MONICA HSIUNG (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: 1 year old;Address;Autopsy;Biometry;Blood specimen;career;Caring;carrier testing;Cause of Death;Cessation of life;Classification;Clinical Management;Clinical Research;Code;cohort;Collaborations;Conceptions;Congenital Abnormality;Data;Death Rate;Development;Diagnosis;Diagnostic;Disease;DNA;Doctor of Philosophy;early childhood;Enrollment;Epidemiology;ethical, legal, and social implication;Evaluation;exome;exome sequencing;experience;Family;Fibroblasts;Follow-Up Studies;gene discovery;Genetic;Genetic Diseases;genetic disorder diagnosis;Genetic Services;genetic testing;genome sequencing;genomic data;Genomic medicine;genomic variation;Genomics;Goals;Grief reaction;Human;human disease;human genomics;improved;infancy;Infant;Infant Mortality;Institution;Insurance;International;Intervention;Knowledge;Laboratories;Learning;Medical Genetics;Mendelian disorder;Mentors;Mentorship;Minority;mortality;mortality statistics;multidisciplinary;neglect;Neonatal;Neonatal Intensive Care Units;neonatal period;Neonatology;novel;Parents;perinatal medicine;Perinatal mortality demographics;Phenotype;Population;population based;postnatal period;prenatal;Prevalence;prevent;Prevention;Process;psychosocial;Public Health;Publishing;Rare Diseases;reproductive;Research;research clinical testing;Research Design;Research Personnel;Research Proposals;skills;Surveys;Test Result;Tissue Sample;Training;transcriptome sequencing;United States;United States National Center for Health Statistics;United States National Institutes of Health;Validation;Variant;Work

PROJECT_TITLE: The Burden of Genetic Disorders in Infant Mortality

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: MH

ED_INST_TYPE: PRIMATE CENTERS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biomedical Imaging;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences

ORG_CITY: LAFAYETTE

ORG_NAME: UNIVERSITY OF LOUISIANA AT LAFAYETTE

ORG_STATE: LA

PHR: Narrative The central nervous system is readily infected by HIV upon systemic infection but represents a separate compartment which only select antiretroviral drugs penetrate, and in which virus evolves independently from the remainder of the body. It also appears that infected cells in the brain contribute to the durable viral reservoir under antiretroviral therapy yet investigating viral dynamics in the brain is almost impossible. Using a macaque model of simian immunodeficiency virus (SIV) that leads to neurological symptoms, we propose to develop new strategies to image SIV in the brain, in real-time, to monitor viral reservoir seeding, persistence and reactivation upon antiretroviral therapy interruption, paving the way for new interventions to minimize neurological damage due to HIV.

PI_NAMEs: SANTANGELO, PHILIP J;VILLINGER, FRANCOIS J (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Acute;acute infection;Address;Anatomy;Anti-Retroviral Agents;antiretroviral therapy;Area;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Cell Lineage;Cell Physiology;Cell Separation;cell type;Cells;Central Nervous System;chronic infection;Chronic Phase;Clinic;Collection;confocal imaging;Data;Data Analyses;Detection;Development;Dose;Environment;Evaluation;Flow Cytometry;Future;Goals;Gut Mucosa;HIV;HIV Infections;Image;imaging system;Imaging Techniques;Imaging technology;ImmunoPET;in vivo;Infection;Interruption;Intervention;Ionomycin;Kinetics;Label;Laboratories;Light;Link;Location;lymph nodes;Lymphoid;Macaca;Macaca nemestrina;Mannitol;Maps;Microscopic;Microscopy;Modeling;Molecular;Monitor;Monkeys;Monoclonal Antibodies;monocyte;Nature;Nervous System Trauma;neuroAIDS;Neurologic Symptoms;nonhuman primate;Organ;Penetration;Peptides;Pharmaceutical Preparations;Plasma;Positron-Emission Tomography;Primates;Process;Production;Proteins;Protocols documentation;Radioisotopes;reproductive tract;Research;Residual state;response;Secondary to;Signal Transduction;Site;SIV;Sorting;Source;Stains;Supporting Cell;Systemic infection;Techniques;Technology;Testing;Time;Tissues;tool;transcriptome sequencing;Transferrin;translation to humans;Viral;viral rebound;Viral reservoir;Virus;Virus Diseases;Virus Latency;Virus Replication;X-Ray Computed Tomography

PROJECT_TITLE: Identification of SIV replication and reservoirs in the CNS


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Rare Diseases

ORG_CITY: ROYAL OAK

ORG_NAME: WILLIAM BEAUMONT HOSPITAL RESEARCH INST

ORG_STATE: MI

PHR: Project Narrative Glioblastoma continues to be a uniformly fatal malignancy despite aggressive therapy. The proposed studies are designed to understand how changes in tumor metabolism can lead to an immune suppression in an effort to identify novel treatment regimens for this aggressive form of cancer.

PI_NAMEs: CHINNAIYAN, PRAKASH  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: aggressive therapy;Alzheimer's Disease;Biological;Brain;cancer therapy;Cells;Clinical;combinatorial;Complex;Coupling;Data;design;FOXO1A gene;Genetically Engineered Mouse;Genomics;Glioblastoma;Glioma;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune Tolerance;Immunologics;Immunosuppression;in vivo;inhibitor;interest;Investigation;Laboratory Study;Macrophage;Malignant Neoplasms;Mediating;Memantine;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Microglia;model design;Modeling;molecular phenotype;monocyte;Mus;neoplastic cell;Neurodegenerative Disorders;Neurosciences Research;next generation;novel;novel strategies;novel therapeutic intervention;Outcome;Parkinson Disease;Pathway interactions;Patients;Peripheral;Phenotype;Play;Pre-Clinical Model;Production;Property;quinolinate;Radiation;radiation response;receptor;Research Design;response;Role;Sampling;Series;Signal Transduction;success;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;Thinking;Treatment Protocols;Tryptophan Metabolism Pathway;tumor;Tumor Immunity;tumor metabolism;Tumor-associated macrophages;Work

PROJECT_TITLE: Quinolinate-induced immune suppression in glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

PI_NAMEs: FU, STEVEN  (contact)

PROJECT_TERMS: Address;Adopted;adult of color;arm;Behavior Control;Behavioral;Biochemical;Black American;Black, Indigenous, People of Color;Cardiovascular Diseases;cardiovascular disorder risk;care fragmentation;Caring;Cessation of life;Chronic;Chronic Disease;Cigarette;cigarette smoking;Clinic;clinical care;Collaborations;Combination Drug Therapy;Combination Medication;Communities;Complex;Counseling;Data;Discrimination;Disparity;Effectiveness;Effectiveness of Interventions;effectiveness-implementation RCT;effectiveness/implementation trial;Electronic Health Record;Electronics;Enrollment;Ensure;Equity;Evaluation;evidence base;experience;Failure;follow-up;future implementation;Goals;Guidelines;Health;health disparity;health equity;health equity promotion;Health Personnel;Health Services Accessibility;Health system;Healthcare Systems;High Prevalence;Hybrids;Hypertension;implementation evaluation;implementation intervention;implementation outcomes;improved;Individual;Intention;Intervention;intervention effect;Mediation;Methods;Minnesota;Morbidity - disease rate;mortality;Motivation;motivational enhancement therapy;Outcome Assessment;outreach;Participant;patient engagement;Patients;Persons;Pharmaceutical Preparations;Physicians;Population;pragmatic trial;Preventive care;Primary Care;primary care patient;primary care provider;primary outcome;Professional counselor;programs;Provider;Public Health;quitline;racism;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;rural area;Rural Health;rural healthcare;Smoke;Smoker;Smoking;smoking abstinence;Smoking and Health Research;smoking cessation;Smoking Cessation Intervention;smoking prevalence;standard of care;Structural Racism;Surgeon;Surveys;System;Target Populations;Telephone;Testing;Tobacco;tobacco abstinence;tobacco cessation intervention;tobacco exposure;Tobacco use;Tobacco Use Cessation;Training;treatment as usual;treatment program;United States Public Health Service;uptake;urban area;Urban Health

PROJECT_TITLE: A Pragmatic Trial of Chronic Disease Approaches To Ameliorate Tobacco Related Cardiovascular Disease Health Disparities


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Networking and Information Technology R&D (NITRD);Prevention;Rehabilitation;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The unprecedented global pandemic has highlighted the digital divide and limited access to alcohol-related treatments among marginalized communities, specifically individuals with lived experience of homelessness. In line with the NIAAA health initiative seeking to integrate technology-based interventions among vulnerable populations, this study directly addresses this mission by proposing innovative methods (i.e., user-centered design + a community based participatory research framework) to adapt an in-person harm reduction for alcohol (HaRT-A) intervention into a telehealth platform (eHaRT-A) that can then be tested and successfully implemented into low-barrier Housing First settings. As healthcare continues to move more services online, it is essential to understand ways to successfully adapt and implement rigorously tested telehealth treatment services for marginalized communities to ameliorate alcohol-related harms.

PI_NAMEs: FROHE, TESSA MARIE (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: 2 arm randomized control trial;Abstinence;acceptability and feasibility;Address;Advocacy;Affect;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol intervention;alcohol research;alcohol use disorder;Alcohols;Award;career;Case Management;Client;Clinical;clinically relevant;Collaborations;Communities;community advisory board;community based participatory research;community engaged intervention;community setting;comparative efficacy;Complement;Consensus;COVID-19;design;Development;digital divide;Discipline of Nursing;drinking;efficacy testing;Enhancement Technology;evidence base;experience;feasibility testing;Feedback;Focus Groups;Foundations;Funding;General Population;global health;Glucuronides;Goals;Grant;Harm Reduction;Health;health related quality of life;Healthcare;High Prevalence;Homelessness;Housing;implementation intervention;improved;Individual;innovation;Intervention;intervention delivery;Lived experience;marginalized community;Measurement;Mentored Research Scientist Development Award;Mentors;Methods;Mission;Morbidity - disease rate;mortality;National Institute on Alcohol Abuse and Alcoholism;online intervention;Outcome;Pain;pandemic disease;Participant;Patient Self-Report;Patients;Persons;Phase;Population;Positioning Attribute;post-doctoral training;prototype;Qualitative Methods;Quality of life;Randomized, Controlled Trials;recruit;reduced alcohol use;reduced substance use;Research;research data dissemination;Research Personnel;Research Priority;Research Project Grants;Risk Factors;Scientist;Series;service gap;Service provision;Services;services as usual;Site;skills;standard of care;statistics;substance use;substance use treatment;supported housing;Symptoms;Technology;technology intervention;telehealth;Testing;therapy development;Time;Training;treatment research;treatment services;United States;Universities;urinary;usability;user centered design;Videoconferencing;virtual healthcare;vulnerable community;Vulnerable Populations;Walking;Washington;web platform;Writing

PROJECT_TITLE: eHaRT-A: Adapting an evidence-based, in-person harm reduction treatment into a virtual care telehealth intervention for people with lived experience of homelessness and alcohol use disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Orphan Drug;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE Impaired relaxation of the heart, termed diastolic dysfunction, is a severe condition leading to significant morbidity and mortality with limited options for treatment. Restrictive Cardiomyopathy is a cardiac disease with particularly severe diastolic dysfunction and poor outcomes, for which there are no specific treatments because the underlying mechanisms are poorly understood. In this proposal, I use novel stem-cell models of Restrictive Cardiomyopathy and large-scale functional genomics analyses to define pathogenic mechanisms that will inform the design of therapeutics for this deadly disease.

PI_NAMEs: STAUDT, DAVID WELLS (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Age Months;Award;Biochemical;Biology;biophysical analysis;Biophysics;Calcium;Cardiac Myocytes;Cardiac Myosins;Cardiomyopathies;Cardiovascular system;career;Cell Line;Cell model;Cells;Childhood;Clinical;Collaborations;Complex;CRISPR interference;CRISPR/Cas technology;Data;Data Set;de novo mutation;Defect;design;Diagnosis;Disease;disease model;DNA Sequence Alteration;experience;Functional disorder;functional genomics;Funding;Genetic;Genetic Diseases;Genomic approach;Goals;Grant;Heart;Heart Diseases;Heart failure;Heart Transplantation;high throughput analysis;high throughput screening;human induced pluripotent stem cells;Hyperactivity;Hypertrophic Cardiomyopathy;Impairment;improved;in vitro Model;Individual;individualized medicine;induced pluripotent stem cell derived cardiomyocytes;insight;knock-down;Laboratories;Leadership;Link;Measurement;Measures;Mediating;Medical;member;Mentors;Mentorship;MicroRNAs;Molecular;Molecular Probes;Morbidity - disease rate;mortality;Motor;Muscle;mutant;Mutation;Myocardium;Myosin ATPase;novel;novel therapeutics;Outcome;Pathogenicity;Pathway interactions;Patients;pediatric patients;Pharmaceutical Preparations;Phenotype;Physicians;Physiological;Physiology;Productivity;Program Description;Proteins;Rare Diseases;Relaxation;Research Personnel;Resources;Rest;Restrictive Cardiomyopathy;Scientist;skills;stem;stem cell model;stem cells;Symptoms;Testing;Therapeutic;therapeutic target;therapy development;Thick;Training;Training Programs;Translating;treatment strategy;Troponin;Troponin T;Ventricular;ventricular hypertrophy;Work;Writing

PROJECT_TITLE: Probing the Molecular Mechanisms of Diastolic Dysfunction Using Patient-Specific Stem Cells

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: FRENCH, SIMONE A. (contact)

PROJECT_TERMS: Address;Adoption;after-school program;American Indians;Behavior;Behavioral;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;care systems;Chronic Disease;Communities;community based participatory research;community burden;community clinic;Conscious;Consensus;Diabetes Mellitus;Diet;Disparity;Dose;Education;Educational Curriculum;Effectiveness;effectiveness evaluation;Environment;Equity;ethnic minority;Evaluation;evidence base;Evidence based intervention;Evidence based program;experience;Family;Food;Future;Goals;Health Personnel;Health Priorities;Healthy Eating;Home visitation;Hypertension;implementation fidelity;implementation intervention;implementation outcomes;implementation process;implementation science;implementation strategy;implementation trial;Individual;innovation;Intervention;Leadership;Low income;Maintenance;marginalization;Measurement;Mentors;Minnesota;minority children;Modeling;Native American community;Native Americans;Obesity;Outcome;personalized approach;Physical activity;prevent;Primary Care;Process;process evaluation;Program Sustainability;programs;Public Health;Race;racial minority;racism;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Design;Research Personnel;Resource-limited setting;Resources;Risk Factors;school district;Schools;Scientist;Self Determination;Site;social;social health determinants;social service provider;socioeconomics;Structural Racism;Structure;System;tool;Training;Twin Cities;Universities;uptake;urban Native American;Work;Youth;youth sports

PROJECT_TITLE: Native American Youth Cardiovascular Disease Prevention: Implementation of Culturally-Tailored Evidence-Based After School and Home Visitation Programs for Healthy Eating and Physical Activity


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Hematology;Microbiome;Neurosciences;Pain Research;Rare Diseases;Sickle Cell Disease

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE: Sickle cell disease is associated with inflammation that promotes vaso-occlusive episodes and eventually organ damage. Our recent studies have revealed important functions of the microbiota and sensory nerves in regulating these manifestations. This proposal will shed light on the mechanistic contributions of aged neutrophils, the specific bacterial strains that protect or promote the disease, and their interplay with nerve-derived signals.

PI_NAMEs: KELLY, LIBUSHA  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Acute;Adhesions;afferent nerve;aged;Aging;Antibiotics;Applications Grants;Automobile Driving;Bacteria;Bacteroides thetaiotaomicron;Binding;Blood flow;Calcitonin Gene-Related Peptide;Calcitonin-Gene Related Peptide Receptor;candidate identification;Capsaicin;Cell Communication;Chronic;Circulation;Clinical;Clinical Trials;Collaborations;Complement;CSF3 gene;cytokine;Data;Deposition;Disease;Dose;Endothelium;Enterococcus gallinarum;Erythrocytes;extracellular;Flow Cytometry;Fluorescence;Funding;Generations;Glucocorticoids;gut microbiota;HDAC4 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;humanized mouse;hydroxyurea;IL17 gene;improved;in vivo;Inflammation;Integrins;Intestinal permeability;intravital microscopy;Iron;Leukocytes;Light;liver injury;Macrophage-1 Antigen;Mass Spectrum Analysis;Mediating;microbial;microbiome alteration;microbiome analysis;microbiota;microscopic imaging;Molecular;mouse model;Mus;Nerve;neuroimmunology;Neurons;Neurotransmitters;neutrophil;Nociceptors;novel;novel marker;Organ;P-Selectin;Pain;Pathogenesis;Pathway interactions;Patients;Penicillins;Phenotype;Play;prevent;probiotic therapy;programs;Proteome;Proteomics;Psychological Stress;RAMP1;receptor;renal damage;Reporting;response;Role;Sampling;Selectins;Severities;Sickle Cell;Sickle Cell Anemia;Signal Transduction;somatosensory;System;Time;TRPV1 gene;Video Microscopy

PROJECT_TITLE: In vivo mechanisms mediating sickle cell vaso-occlusion and organ damage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(02)M]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: PROVIDENCE

ORG_DEPT: PHYSICS

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative The project will develop an innovative magnetic imaging modality for brain magnetoencephalography (MEG) based on the quantum mechanical tunneling of spin-polarized electrons in a magnetic tunneling junction (MTJ). MTJ sensors are the most sensitive room-temperature solid-state magnetic sensors with a large magnetic field dynamic range. Our MTJ-MEG system can become deployed for real-world applications without a magnetically shielded room and specialized nulling coils.

PI_NAMEs: SANES, JEROME N;XIAO, GANG  (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Address;Artificial Intelligence;biophysical model;Brain;brain electrical activity;brain health;Brain imaging;BRAIN initiative;Cells;Clinical;Cognition;Cognitive;Consumption;Coupled;cryogenics;Data;density;design;Development;Devices;Electrons;Engineering;Environment;experience;fabrication;Geometry;Goals;Head;Heating;Helmet;Human;Human Volunteers;imaging modality;Immune;improved;Infrastructure;innovation;interdisciplinary collaboration;life span;light weight;magnetic field;Magnetism;Magnetoencephalography;Measures;Memory;Mental Health;microelectronics;miniaturize;Modeling;Monitor;Motion;Motor;Movement;nanoscale;Neurosciences;Noise;Non-Invasive Detection;non-invasive imaging;Optics;Performance;Phase;Physics;Planet Earth;portability;portable monitoring;prototype;Publishing;Pump;quantum;Quantum Mechanics;Radial;real world application;Records;Resolution;response;Scalp structure;sensor;Sensory;Series;Signal Transduction;solid state;Source;spatiotemporal;Speed;Structure;superconducting quantum interference device;System;system architecture;Technology;technology development;Temperature;temporal measurement;Thick;Touch sensation;United States National Institutes of Health;vapor;Vision;wearable device

PROJECT_TITLE: Development of Quantum Magnetic Tunneling Junction Sensor Arrays for Brain Magnetoencephalography (MEG) under Natural Settings


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative  Neurons in the brain wire together to form circuits that perform the computations necessary for learning, cognition, and behavior. But the brain is composed of thousands of unique cell types that differ in the sets of genes that they each express. We propose to develop a more efficient method to study how these unique cell types connect into neural circuits by employing state-of-the-art tools for visualizing both neuronal activity and genetic identity.

PI_NAMEs: MOYA, MARIA VICTORIA (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Adopted;anatomical tracing;Anatomy;Architecture;Area;Axon;Basal Ganglia;Behavior;Biological Assay;Brain;brain cell;Brain region;career;Catalogs;Cell Differentiation process;cell type;Cells;Cellular Structures;Cerebellum;Classification;Cognition;Complex;computational pipelines;Coupled;Data;Development;Distant;experience;experimental study;Fellowship;Fluorescent in Situ Hybridization;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Identity;Image;image registration;In Situ;In Situ Hybridization;In Vitro;Learning;Light;Link;Maps;Measures;Methodology;Methods;Molecular;Motor;motor behavior;Motor Cortex;Movement;neural;neural circuit;Neurons;neurophysiology;Neurosciences;neurotransmission;next generation sequencing;Optical Methods;Optics;optogenetics;Output;Pathway interactions;Pattern;Perception;Physiology;Population;presynaptic;prototype;Reporting;Role;single cell sequencing;skills;Specificity;Structure;Synapses;Synaptic Potentials;System;Techniques;Technology;Testing;Thalamic structure;Theoretical model;tool;transcriptomics;Visualization;Visualization software;voltage;Work

PROJECT_TITLE: A Scalable Method for Mapping Microconnectivity in Transcriptomically Distinct Neuron Types


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Naphthalenones are bicyclic scaffolds found in many natural and synthetic compounds which display a diverse range of biological activities including anti-viral, anti-bacterial, and anti-fungal properties. Through protein engi- neering and directed evolution, I propose to generate enzymes capable of catalyzing dearomatization of planar naphthols into three-dimensional naphthalenone scaffolds via nitrene or carbene insertions. This work will open new avenues of enzyme catalyzed nitrene or carbene chemistries, as well as provide a facile and sustainable method for transforming readily available aromatic feedstocks into intricate pharmacophores.

PI_NAMEs: SICINSKI, KATHLEEN M (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TITLE: Dearomatization of Planar Aromatic Cores into Three-Dimensional Scaffolds with Defined Stereochemistry


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cardiovascular;Heart Disease;Immunotherapy;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Trametinib is a targeted cancer therapy that prolongs life in patients with melanoma and is being actively studied in clinical trials for numerous other common malignancies. Trametinib is associated with potentially severe heart injury and heart failure, though the mechanism of that cardiotoxicity is presently unknown. In this proposal we seek to expand upon our recent novel findings that trametinib compromises the ability of heart muscle cells to generate energy and leads to inflammation, potentially important reactions in both the heart and cancer.

PI_NAMEs: JENSEN, BRIAN C (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Adverse effects;Allosteric Regulation;anti-cancer;Bioenergetics;Biology;BRAF gene;Breast Cancer Cell;cancer cell;cancer therapy;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiotoxicity;cardiovascular effects;Cessation of life;Clinical Trials;clinically relevant;combination cancer therapy;Combined Modality Therapy;Common Neoplasm;Complex;complex IV;Coupled;cytokine;Data;diagnostic platform;Electron Transport;Etiology;experimental study;Extracellular Signal Regulated Kinases;FDA approved;Functional disorder;Future;Genetic;genetic manipulation;Heart;Heart failure;Heart Injuries;Heart Mitochondria;Human;Immune;immune activation;Immune checkpoint inhibitor;Immune response;Impairment;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;injured;Injury;innate immune pathways;Innate Immune Response;Life;Malignant Neoplasms;MAP2K1 gene;MAPK3 gene;Mediating;MEK inhibition;MEKs;Melanoma;Melanoma patient;Mitochondria;Molecular;mouse model;Mus;Muscle Fibers;Myocardial;novel;Oxidative Phosphorylation;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Patients;Pattern;Pattern recognition receptor;Permeability;pharmacologic;Phase;Phenotype;Phosphorylation;Physiology;pre-clinical;Process;programmed cell death ligand 1;Publishing;Ras/Raf;Reaction;Regulation;Research Personnel;respiratory;Risk;Role;STAT3 gene;targeted cancer therapy;targeted treatment;Testing;Therapeutic;Toxic effect;Transcript;transcriptome sequencing;transcriptomics;triple-negative invasive breast carcinoma;tumor;tumorigenesis;Work

PROJECT_TITLE: Defining the role of mitochondrial injury in MEK inhibitor cardiotoxicity

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Mental Health;Obesity;Prevention;Social Determinants of Health;Urologic Diseases

ORG_DEPT: FAMILY MEDICINE

PHR: Narrative The proposed etiologic research utilizes data collected from a longitudinal cohort of U.S. women and men across the past 30 years, as well as newly collected data. This research examines four interrelated pathways by which psychosocial and socioeconomic stressors may lead to poorer bladder health (lower urinary tract symptoms [LUTS] and impact of symptoms): affective, cognitive, behavioral, and physiological pathways. With the ability to analyze stressors across the life course, this novel research has the potential to inform “upstream” approaches to prevent LUTS and promote bladder health (e.g., amelioration of specific stressors shown to serve as risk factors, enhancement of social support and ties shown to serve as a protective factors), as well as “downstream” prevention and treatment approaches (e.g., treatment of depressive symptoms; cognitive training exercises; weight loss; behavior modification, including pelvic floor exercises).

PI_NAMEs: BRADY, SONYA S (contact);MARKLAND, ALAYNE DENISE

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Adult;Adult women;Affect;Affective;Age;aged;Ancillary Study;Behavior Therapy;Behavioral;Biological Markers;biopsychosocial;black women;Bladder;Blood flow;Blood Vessels;Body Weight decreased;cardiovascular risk factor;care giving burden;Childhood;Chronic;Cities;clinical examination;Cognitive;cognitive function;cognitive training;Cohort Studies;Coronary artery;Data;Data Collection;depressive symptoms;Development;Discrimination;Early treatment;Economic Burden;Environment;environmental stressor;epidemiology study;Etiology;Europe;evidence base;Exercise;Family;Financial Hardship;Funding;Future;Health;Hyperglycemia;Hypertension;Impaired cognition;improved;Individual;Inflammatory;Interview;Investigation;Life Cycle Stages;Link;Longitudinal cohort;Longitudinal cohort study;lower urinary tract symptoms;Measures;Mediating;Mediation;men;micturition urgency;Modification;Muscle function;Muscle Weakness;Nocturia;novel;novel strategies;Obesity;Occupational;Occupations;Overactive Bladder;Pain;Pathway interactions;Patient Recruitments;Pelvic Floor Muscle;Pelvic floor structure;Peripheral;Personal Satisfaction;physical inactivity;Physiological;Population;Prevalence;prevent;Prevention;Prevention Research;Productivity;protective factors;Psyche structure;psychosocial;recruit;Research;resilience;Resources;Risk;Risk Factors;Role;Smoking;social;Social Network;Social status;Social support;Social Well-Being;socioeconomics;stress management;Stress Urinary Incontinence;Stressful Event;stressor;Symptoms;Travel;Unhealthy Diet;United States;United States National Institutes of Health;Urethra;Urinary Incontinence;Weight Gain;White Women;Woman;Work

PROJECT_TITLE: CARDIA-PLUS: A Life Course Investigation of Biopsychosocial Pathways to Bladder Health and Lower Urinary Tract Symptoms

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Dissemination and Implementation Research;Hematology;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE: Recent studies show that if preventative dose anticoagulation is provided to outpatients with cancer at high risk for clotting, it reduces the risk of cancer associated thrombosis, which is the leading non-cancer cause of death among this population. While guidelines suggest offering this potentially lifesaving therapy to high-risk patients with an acceptable bleeding risk, it is not routinely done. This study will identify strategies to improve the appropriate use of preventative anticoagulation for patients with cancer in diverse settings and pilot test an intervention to improve the quality of care patients with cancer receive.

PI_NAMEs: SCHAEFER, JORDAN  (contact)

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TERMS: Academic Medical Centers;Active Learning;Address;Agreement;American Society of Clinical Oncology;American Society of Hematology;Anticoagulants;Anticoagulation;Assessment tool;Award;Awareness;cancer risk;cancer therapy;Caring;Cause of Death;Cessation of life;chemotherapy;Clinic;clinical efficacy;Clinical Investigator;clinical practice;Clinical Trials;Coagulation Process;Collaborations;Communities;Community Practice;community setting;Complex;cost;Data;Data Analyses;Dedications;Dose;Educational workshop;efficacy evaluation;Eligibility Determination;Environment;evidence base;experience;Foundations;Goals;Guidelines;Health Policy;Hematologist;Hemorrhage;Hemostatic function;high risk;implementation evaluation;implementation intervention;implementation outcomes;implementation process;implementation science;implementation strategy;improved;Incidence;innovation;Institution;interest;International;Intervention;Interview;Jordan;K-Series Research Career Programs;Life;Malignant Neoplasms;Maps;meetings;member;Mentors;Mentorship;Michigan;multi-component intervention;Multicenter Studies;multidisciplinary;National Comprehensive Cancer Network;novel;Oncologist;Oncology;Oral;Outcome;Outpatients;Participant;patient population;Patients;Patterns of Care;Pharmacists;pharmacologic;Physicians;pilot test;Population;preventive intervention;Prophylactic treatment;Qualitative Methods;Qualitative Research;Quality of Care;Recommendation;Research;Research Methodology;Research Personnel;Research Project Grants;Resource-limited setting;Resources;Risk;Risk Assessment;Risk Reduction;Sampling;Self Efficacy;Site;skill acquisition;skills;Societies;Structure;success;Testing;Theoretical Domains framework;Thrombosis;thrombotic;Time;Training;Training Activity;Universities;uptake;venous thromboembolism

PROJECT_TITLE: An Intervention to Reduce Cancer Associated Thrombosis Through Improved Prophylaxis


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_DEPT: GENETICS

PHR: Project Narrative Virus-induced diseases represent a significant ongoing threat to human health, and the fight against these viruses requires a well-trained virology workforce. To meet this need, we are proposing the renewal of the UNC-Chapel Hill Virology T32 Program, which provides our pre-doctoral trainees with outstanding training in fundamental virology, while providing them with world-class research training focused on a diverse set of RNA viruses, DNA viruses, or retroviruses.

PI_NAMEs: HEISE, MARK T (contact);MOODY, CARY A

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Molecular Biology of Viral Diseases Predoctoral Training Grant

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Rare Diseases;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The T32 Urologic Oncology Research Training Program at Memorial Sloan Kettering Cancer Center (MSK) trains qualified urologists for academic careers as clinician-scientists focused on eliminating suffering and death from genitourinary cancers, which comprise 21% of all non-skin cancers and cause 10% of all cancer deaths in the United States.

PI_NAMEs: CARVER, BRETT STEWART (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Research Training;Training Programs;Urologic Oncology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE The goal of this R33 renewal grant application entitled “Geriatric Oncology Research Infrastructure to Improve Clinical Care” is to further expand the Cancer and Aging Research Group’s (CARG) national research infrastructure to support innovative investigators, leaders, and projects to answer significant interdisciplinary research questions at the aging and cancer interface. Ultimately, the proposed activities will substantially expand CARG’s infrastructure to advance high-impact, equitable research aimed at improving the care of older adults with cancer globally.

PI_NAMEs: DALE, WILLIAM  (contact);KLEPIN, HEIDI DIANA;MOHILE, SUPRIYA G.

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acceleration;Achievement;Address;Advocacy;Advocate;Age;Aging;American Society of Clinical Oncology;anti-cancer research;Applications Grants;Area;Award;Cancer Research Infrastructure;career development;Caregivers;Caring;clinical care;clinical practice;Collaborations;Communication;Country;Data;Dedications;design;Development;Elderly;Equity;equity, diversity, and inclusion;Fostering;Foundations;Geriatric Assessment;Goals;Grant;Guidelines;improved;Infrastructure;infrastructure development;innovation;Interdisciplinary Study;International;Intervention;Leadership;leadership development;Malignant Neoplasms;member;Mentors;Mentorship;Methodology;next generation;novel;older adult;older patient;Oncology;patient advocacy group;patient oriented;Population;Principal Investigator;Productivity;Publishing;Randomized, Controlled Trials;Research;Research Infrastructure;Research Personnel;Resources;response;Scholarship;Science;Site;Toxicity due to chemotherapy;video chat;Vision;web site


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative Whether attending to the road while driving or trying to find your keys on a cluttered desk, our ability to select relevant information and ignore irrelevant and distracting information is critical for survival. This proposal aims to identify what attentional processes best support the effective ignoring of distractors by comparing experience- based attentional suppression to volitional suppression of irrelevant and distracting information. The results of this proposal will help uncover how variations in the ability to ignore distractions give rise to common cognitive disorders.

PI_NAMEs: STOERMER, VIOLA S. (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Address;Appearance;Attention;Attention deficit hyperactivity disorder;attentional control;Automobile Driving;Behavior;Behavioral;brain electrical activity;Bypass;Clinical;Clutterings;Cognition;Cognition Disorders;cognitive control;Computer Models;Cues;Diagnosis;diagnostic development;diagnostic tool;Dissociation;distraction;Electrophysiology (science);Environment;Event-Related Potentials;experience;experimental study;Goals;Grant;Human;Impairment;Individual;information processing;insight;Intervention;Knowledge;Learning;Link;Measures;Mental Depression;Mental disorders;Methods;Modeling;neural;neuromechanism;novel;Outcome;Participant;Perception;Perceptual Disorders;Performance;Persons;Population;Predictive Factor;Process;Psychophysics;Research;Resource Allocation;Resources;response;Schizophrenia;selective attention;Sensory;sensory input;sensory system;Series;Shapes;Speed;Structure;System;Testing;theories;Time;Translating;Variant;Visual evoked cortical potential;visual search;Work;Workplace

PROJECT_TITLE: Experience-based and intentional suppression of distracting information

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Neurodegenerative

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Mitochondria provide cells with crucial metabolites, and they are hubs in signaling networks that control cell survival or the response to viral attack. To prevent mitochondrial decline and associated diseases, such as cancer or neurodegeneration, cells possess conserved stress responses that detect and either repair or degrade defective mitochondria. This proposal will dissect the function and regulation of the conserved reductive stress response, which senses a deleterious depletion of beneficial reactive oxygen species and in turn activates the electron transport chain. Our work will reveal principles of mitochondrial signaling and lay the foundation for innovative treatments that use mitochondrial activation to combat neurodegenerative diseases.

PI_NAMEs: RAPE, MICHAEL P (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: 26S proteasome;Address;Affect;Aging;Biochemical;biological adaptation to stress;Cardiomyopathies;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Death;Cell division;Cell Survival;Cells;cellular targeting;Collaborations;combat;Complement;Cyclin D1;Cytoplasm;Data;Development;Developmental Delay Disorders;Diabetes Mellitus;Disease;Drops;Electron Transport;Ensure;Environment;Enzymes;Excision;Foundations;gain of function mutation;Gatekeeping;Genetic;genetic analysis;Goals;Growth Factor;hallmarks of aging;Heart;Homeostasis;human disease;Immune response;Immune signaling;Inflammatory;inhibitor;innovation;Ion Channel;Malignant Neoplasms;Mediating;Metabolic;Metabolic Control;Metabolic Diseases;Metabolism;Methods;Mitochondria;Mitochondrial Proteins;Modality;Modeling;Modification;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuron development;novel;novel therapeutics;Organelles;Outer Mitochondrial Membrane;Output;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Physiological;Play;Population;preservation;prevent;Production;programs;Proliferating;Protac;protein degradation;protein misfolding;Proteins;Reaction;Reactive Oxygen Species;recruit;Regulation;repaired;Replication Initiation;response;Role;Running;sensor;Sensory;Signal Pathway;Signal Transduction;Source;Stress;Surface;Testing;Therapeutic;Tissues;TOM translocase;transmission process;tumorigenesis;ubiquitin-protein ligase;Viral;Work

PROJECT_TITLE: Function and regulation of the reductive stress response

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Child Abuse and Neglect Research;Childhood Injury;Epilepsy;Neurodegenerative;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Stroke;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Violence Research;Youth Violence

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE  It is estimated that the majority of severe head injuries in children under age 2 are due to abuse. Hemispheric hypodensity is a striking pattern of brain damage often resulting from inflicted trauma where tissue damage evolves over hours or days and for which there is no treatment. Understanding the pathophysiology of this severe injury will identify potential therapeutic targets that may result in therapies that reduce the burden of disability and mortality for victims of abusive head trauma.

PI_NAMEs: COSTINE-BARTELL, BETH A (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Accident and Emergency department;Accidents;Acute;Admission activity;Age;age related;Anesthesia procedures;anti-epileptic agents;Apnea;Area;Biological Markers;Blood Vessels;Brain Hypoxia-Ischemia;Brain Injuries;brain morphology;Brain region;cerebral atrophy;Characteristics;Child;Childhood;Childhood Injury;Clinical;Clinical Management;clinically relevant;Contralateral;Craniocerebral Trauma;Critical Care;Death Rate;Depressed mood;Development;disability burden;disabled;Elements;Event;Evolution;Focal Seizure;Functional disorder;Future;Goals;Guidelines;hemisphere damage;Hemorrhage;Hospitalization;Hospitals;Hour;Human;Hypoventilation;Image;Impairment;Infant;Injury;innovation;Intensive Care;Kainic Acid;Location;Matrix Metalloproteinases;Mechanics;Metabolic acidosis;Modeling;mortality;Multiple Trauma;neural;Neurologic;Neurological status;Outcome;Pattern;Pediatric Intensive Care Units;permissiveness;prevent;Protocols documentation;Radiology Specialty;Seizures;severe injury;Severities;Shaken baby syndrome;Subarachnoid Hemorrhage;Subdural Hematoma;Testing;Therapeutic;therapeutic target;therapy development;Time;time interval;tissue trauma;Tissues;Toddler;Trauma;Traumatic Brain Injury;Up-Regulation;vasogenic edema;X-Ray Computed Tomography

PROJECT_TITLE: Identifying Potential Therapeutic Targets for Abusive Head Trauma

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative.………………………………………………………………………………………………. Metastasis remains to be the leading cause of cancer death worldwide including metastatic prostate cancer, which poses poor prognosis for patients diagnosed with it. Understanding how cancer intrinsic signaling, metastatic tissue biological players, and aging contribute to dormancy and reawakening is paramount to improving treatment strategies to control metastasis and extend patients overall survival rates. This research proposal will identify intrinsic and extrinsic regulators of skeletal prostate cancer dormancy in the context of aging to provide a better understanding of skeletal metastasis initiation.

PI_NAMEs: NASR, MOSTAFA M. (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Ablation;ACVR1 gene;Address;Aging;aging related;Agreement;American;Androgens;antagonist;Apoptosis;Apoptotic;Arteries;BCL-2 Protein;BCL1 Oncogene;BCL2L11 gene;Benign;Bioinformatics;Biological;Bioluminescence;BMP7 gene;bone;cancer cell;Cancer Etiology;Cancer Patient;CASP3 gene;Castration;CDK4 gene;Cell Communication;Cell Cycle Progression;Cell Cycle Regulation;Cell Line;Cells;Cessation of life;ChIP-seq;Coculture Techniques;Cytometry;Data;Diagnosis;disease model;DNA Binding;Ectopic Expression;experimental study;Fluorescence-Activated Cell Sorting;Gene Expression Profiling;Genes;Genetic;genetic approach;Growth;Hemostatic Agents;high dimensionality;Histologic;Homeostasis;Human;human old age (65+);Immunocompetent;Impairment;improved;In Vitro;in vitro Model;in vivo;in vivo evaluation;inhibitor;insight;knock-down;Knowledge;LAPC4;Lesion;Limb structure;Literature;Malignant neoplasm of prostate;Malignant Neoplasms;MAP Kinase Gene;men;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Methods;Modeling;Molecular;Molecular Target;mortality;Mus;mutant;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Operative Surgical Procedures;p38 Mitogen Activated Protein Kinase;Parents;Pathway Analysis;Pathway interactions;patient prognosis;Patients;pharmacologic;Phase;Phosphorylation;Pre-Clinical Model;prevent;Primary Neoplasm;pro-apoptotic protein;programs;prostate cancer cell;prostate cancer cell line;prostate cancer model;Protein Region;Proteins;Publishing;receptor;receptor expression;Recurrent disease;Relapse;Research;Research Proposals;Resistance;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Site;skeletal;Skeleton;Small Interfering RNA;stem cells;Stromal Cells;Survival Rate;Techniques;Technology;Testing;Tissues;transcription factor;transcriptome;transcriptome sequencing;treatment strategy;tumor;Up-Regulation;Validation;Work;Xenograft Model;Zinc Fingers

PROJECT_TITLE: Dissecting the intrinsic and extrinsic regulators of prostate cancer dormancy in the bonemicroenvironment.


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Sleep Research

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Sleep selectively prioritizes information that is emotional, rewarded, and important for future use. Disruption of this prioritization process may underlie psychological disorders such as depression, anxiety, and post- traumatic stress disorder, and may be especially exacerbated by sleep disruption. The proposed research will further our understanding of how sleep selectively prioritizes important information, examining its neural mechanisms and generalization across the cognitive domains of emotional memory and problem solving.

PI_NAMEs: SANDERS, KRISTIN  (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Address;Adult;Affect;Age;Anxiety;Applications Grants;Area;awake;Brain;career;clinical diagnosis;Cognition;Cognitive;Cognitive deficits;cognitive neuroscience;Communication;Complex;Coupling;Cues;Detection;Development;Educational workshop;Electroencephalography;Emotional;experience;experimental study;Fellowship;Foundations;Future;Hour;Impairment;Knowledge;Laboratories;Learning;Link;Medical;meetings;Memory;memory consolidation;memory process;Mental Depression;Mental disorders;Mentorship;neural;neural correlate;neuromechanism;Neurosciences;non rapid eye movement;novel;Participant;Personal Satisfaction;Persons;Polysomnography;Post-Traumatic Stress Disorders;power analysis;Problem Solving;Process;Publications;REM Sleep;Research;Research Ethics;Research Personnel;Research Proposals;Rewards;Role;skills;Sleep;Sleep Disorders;Sleep disturbances;sleep spindle;Sleep Stages;Solid;sound;Specificity;Stress;Techniques;Testing;Time;Training;young adult

PROJECT_TITLE: The impact of sleep on memory selectivity and problem solving: Common and distinct neural mechanisms


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Pediatric;Prevention

PHR: NARRATIVE Emerging evidence suggests that infants with greater appetitive drive may benefit from different feeding approaches for the prevention of obesity and chronic disease, including slowing the rate of milk intake and improving satiation signaling. The proposed project will, through a mentored training phase, examine infant and mother behavior, as well as their dyadic interaction during feedings with slower milk delivery, compared with faster milk delivery. This will be followed by an independent study to examine how these behaviors develop across multiple feedings.

PI_NAMEs: CRANDALL, AMANDA K (contact)

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: Address;Age;aged;Award;Behavior;behavior change;Behavioral;Behavioral Mechanisms;Child;Chronic Disease;Code;cohort;comparative;Consumption;Cues;Desire for food;Development;Distress;dyadic interaction;Eating;Eating Behavior;Effectiveness;Energy Intake;Environment;Equation;Equity;excessive weight gain;experience;experimental study;feeding;Feeding behaviors;Feeling;Food;Frequencies;Growth;Health;hedonic;Hour;Hunger;improved;infancy;Infant;Intake;Intervention;Investigation;Knowledge;life span;Longitudinal cohort study;Measures;Mentors;Milk;milk intake;Modeling;Mothers;multidisciplinary;Nature;nutrition;obesity in children;obesity prevention;Parents;Pathway interactions;Pattern;Personal Satisfaction;Phase;Physiological;Physiology;pleasure;pressure;prevent;Prevention;Prevention approach;programs;Psychology;Public Health;Reporting;Research;response;Risk;Sampling;Satiation;Scientist;Signal Transduction;sucking;Sucking Behavior;Techniques;Testing;therapy design;Training;United States;Video Recording;Weight Gain

PROJECT_TITLE: Managing Excess Infant Energy Intake by Increasing Satiation Responsiveness in Dyadic Feeding Interactions

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Telehealth

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The opioid crisis has exponentially harmed Black Americans in the United States in recent years and this population continues to face significant barriers in access to appropriate treatment for opioid use disorder (OUD) and commonly occurring mental disorders (COMD). Recently the US Department of Health and Human Services’ Overdose Prevention Strategy acknowledged the importance of addressing the opioid overdose crisis through evidence-based treatment and recovery support - two essential elements of this proposal. This study aims to adapt and test the preliminary efficacy of a mobile Health intervention specifically tailored for Black Americans with OUD plus COMD.

PI_NAMEs: SZLYK, HANNAH  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Achievement;acronyms;addiction;Address;Adherence;Anxiety;Applied Skills;Area;Attitude;Award;barrier to care;Black American;Black Populations;Black race;career;career development;Caring;Cessation of life;Cities;Client;Clinical;clinical care;Clinical Trials;community based care;Control Groups;cost effective intervention;Data;depressive symptoms;design;Development;digital;digital treatment;Discrimination;Economics;Elements;Environment;Evidence based treatment;experience;Exposure to;Face;Feedback;Focus Groups;Fostering;Foundations;Future;Goals;health care availability;Health education;health equity;health equity promotion;Healthcare;high risk;implementation facilitators;implementation science;implementation strategy;improved;Inequity;innovation;Intervention;Interview;Life;Location;medical schools;medication for opioid use disorder;meetings;Mental Depression;Mental disorders;Mental Health;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;metropolitan;mHealth;mhealth interventions;Minority Groups;Missouri;mortality;motivational enhancement therapy;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid policy;opioid use disorder;Outcome;Overdose;overdose prevention;overdose risk;Participant;peer;peer support;Persons;Pharmaceutical Preparations;Population;prevent;Prevention strategy;primary outcome;Provider;psychoeducation;Public Health;Race;Randomized;Randomized, Controlled Trials;Recovery;Recovery Support;Reporting;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Resources;response;Risk Factors;Scientist;secondary outcome;skill acquisition;skills;sobriety;social factors;social stigma;structural determinants;Structural Racism;Structure;substance use;substance use treatment;success;symposium;Telephone;Testing;Text Messaging;Therapeutic Intervention;tool;Training;Training Activity;treatment adherence;United States;United States Dept. of Health and Human Services;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;Universities;uptake;usability;user centered design;Washington

PROJECT_TITLE: Leveraging mHealth to Increase Health Equity among Black Individuals with Opioid Use Disorder and Commonly Occurring Mental Health Disorders

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Prevention;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE To reduce disparities in breast cancer survival, there is an urgent need to develop optimal screening strategies for the early detection of aggressive, young onset breast cancers among women at high risk for breast cancer based on inherited risk factors and genetic ancestry. Within the Chicago Alternative Prevention Study for BReast CAncer in Diverse Populations of High-Risk Women (CAPSBRACA), we will refine and expand on our biannual MRI protocol such that it is efficient, feasible and sustainable even in under resourced communities. Through a pragmatic study design, we will improve long-term adherence to screening in young women and establish a longitudinal cohort of high risk women undergoing intensive surveillance for future cancer interception clinical trials.

PI_NAMEs: ABE, HIROYUKI ;KARCZMAR, GREGORY S.;OLOPADE, OLUFUNMILAYO F. (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Abbreviations;Address;Adherence;Affect;African ancestry;Age;Age Years;American College of Radiology;Benign;Biological Markers;Black race;BRCA1 gene;BRCA1 Mutation;BRCA2 gene;BRCA2 Mutation;Breast;Breast Cancer Detection;Breast Cancer Risk Factor;breast cancer survival;California;Cancer Detection;cancer health disparity;cancer invasiveness;cancer risk;Chicago;Clinic;Clinical;Clinical effectiveness;Clinical Trials;Collaborations;Color;Communities;Contralateral;COVID-19 pandemic;Data;deep learning;deep learning model;Detection;Diagnosis;Diagnostic;Diffusion;Diffusion Magnetic Resonance Imaging;disparity reduction;Drug Kinetics;Early Diagnosis;efficacy evaluation;Enrollment;Evaluation;experience;Family history of;Funding;Future;Genetic;Genetic Risk;genetic testing;genetic variant;Genomics;Germ-Line Mutation;high risk;high risk population;High Risk Woman;Hispanic;Hospitals;Image;imaging facilities;imaging modality;improved;Individual;Influentials;Inherited;innovation;Institution;Intervention;Ipsilateral;Kinetics;Label;Laboratory Research;Lesion;Location;Longitudinal cohort;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammographic screening;Measurement;Measures;Methods;model building;Modeling;mutation carrier;novel;Outcome;Output;PALB2 gene;Participant;Performance;personalized approach;Population;Population Heterogeneity;Population Sciences;pragmatic study;Predisposition;premature;Prevention;primary care setting;Protocols documentation;quality assurance;radiologist;Recommendation;recruit;Research Design;Resources;Risk;Risk Factors;Risk Management;risk prediction model;risk stratification;Science;screening;self supervised learning;Side;Site;standard of care;Standardization;Surveillance Program;Techniques;Testing;Tissues;Training;Translating;United States Preventative Services Task Force;Validation;Vascular blood supply;Woman;Work;young woman

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Neurosciences;Orphan Drug;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stomach Cancer

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Timothy C. Wang, NCI R35 This project seeks to investigate the role of nerves and myeloid cells in the development and progression of digestive cancers, including gastroesophageal, colon and pancreatic cancers. The project builds upon previous work suggesting that these elements can modulate stem cells and cancer; and that targeting them may make it possible to prevent or treat tumors.

PI_NAMEs: WANG, TIMOTHY CRAGIN (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: 3-Dimensional;afferent nerve;Area;Bioinformatics;cancer cell;carcinogenesis;CD8-Positive T-Lymphocytes;cell type;Chronic;Clinical Trials;Colitis;Collaborations;Colon Carcinoma;Data;Development;effective therapy;Elements;Epigenetic Process;epithelial stem cell;Epithelium;Esophageal Adenocarcinoma;Esophagitis;Evolution;Gastritis;gastroesophageal cancer;Genetic;Goals;Inflammation;Inflammatory;Laboratories;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;Modeling;Myeloid Cells;neoplastic cell;Nerve;Neurons;neurotransmission;Organoids;Pancreatitis;Peripheral Nervous System;Preneoplastic Conditions;prevent;Reflex action;Regenerative response;release of sequestered calcium ion into cytoplasm;Role;single-cell RNA sequencing;stem;stem cell division;stem cells;Stromal Cells;Stromal Change;targeted treatment;trefoil factor;tumor;Tumor Immunity;Work

PROJECT_TITLE: The role of stem cells and the microenvironment in gastrointestinal cancers


ORG_CITY: BOSTON

PHR: Project Narrative Portable, low-field MRI has the exciting potential to dramatically increase the accessibility of MRI for bed-side imaging and use in low-resource settings. However, the most significant limitation of these low-field scanners is the inferior image quality that arises from the lower MR signal amplitude. Our aim is to offset this limitation with novel, stretchable receiver coils that will adapt to the subject to maximize the receiver sensitivity, with the ultimate goal of improving portable MRI image quality and clinical utility.

PI_NAMEs: COOLEY, CLARISSA ZIMMERMAN (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Adoption;Adult;Algorithms;Brain;Brain imaging;Clinical;clinical care;Contrast Media;cost;Critical Care;design;design and construction;Development;Diameter;Disadvantaged;flexibility;Frequencies;Goals;high risk;Image;improved;Individual;Inferior;Infrastructure;interest;magnetic field;Magnetic Resonance Imaging;Measurement;Methods;Minor;Monitor;Neonatal;neonate;Noise;novel;operation;Output;Pathology;patient population;Patients;Planet Earth;point of care;Point-of-Care Systems;portability;programs;Resolution;Resource-limited setting;RF coil;Risk Reduction;Role;Safety;Sampling;scale up;Scanning;Shapes;Signal Transduction;Stretching;System;Technology;Temperature;Time;transmission process;trend;Validation;vector;voltage;volunteer

PROJECT_TITLE: Stretchable Coils for Low-Field, Portable MRI

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: In this application, we propose to use synthetic biology approaches to engineer self- replicating RNAs as powerful anti-cancer therapeutics. Our RNA-based synthetic gene circuits will provide a new paradigm for cancer immunotherapy of diverse cancers.

PI_NAMEs: DONG, YIZHOU ;IRVINE, DARRELL J;WEISS, RON  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: anti-cancer therapeutic;anti-tumor immune response;Beds;cancer cell;Cancer Etiology;cancer immunotherapy;Cancer Model;CAR T cell therapy;Cell Death;cell type;Cells;Cessation of life;Combined Modality Therapy;constitutive expression;Cues;Data;design;Disseminated Malignant Neoplasm;Distal;Engineering;Event;Evolution;FDA approved;Formulation;Gene Expression;Genes;Human;Immune;immune checkpoint blockade;Immune signaling;Immune system;immunogenic;Immunotherapy;In Vitro;in vivo;Injections;interest;KRASG12D;Link;lipid nanoparticle;Lung;Lung Adenocarcinoma;lung cancer cell;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Minority;Modeling;mouse model;neoplastic cell;next generation;nucleic acid delivery;Oral;Patients;Pharmaceutical Preparations;programs;promoter;Publishing;recruit;Replicon;response;RNA;RNA replication;Safety;Series;Signal Pathway;small molecule;Solid Neoplasm;synthetic biology;Synthetic Genes;T-Lymphocyte;Technology;technology platform;Testing;Therapeutic;therapeutic evaluation;TP53 gene;Transfection;Treatment Efficacy;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;ultrasound

PROJECT_TITLE: Immunotherapy via engineered therapeutic programs in tumors using RNA


NIH_SPENDING_CATS: Urologic Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Benign prostatic hyperplasia (BPH) can induce bladder outlet obstruction (BOO) with associated lower urinary tract symptoms that can interfere with the quality of life and are often difficult to treat. This R01 research will include in vivo and in vitro studies of BOO in a rat model that will provide scientific insights into BOO while also driving the development of a digital twin of the rat bladder that will be used to design and evaluate combined surgical/pharmacological treatments. The successful completion of this work will also provide a translational foundation for developing digital twins for BOO patients that ultimately will enable more effective and patient tailored treatments to avoid the debilitating side effects of BOO.

PI_NAMEs: ROBERTSON, ANNE MARIE (contact);WATTON, PAUL ;YOSHIMURA, NAOKI

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;Aging;Anatomic Models;animal data;Animals;associated symptom;Attention;Automobile Driving;Benign Prostatic Hypertrophy;bioimaging;Biology;biomechanical model;Biomechanics;Bladder;Bladder Calculi;Bladder Dysfunction;Bladder neck obstruction;Clinic;Clinical;Compensation;computer framework;constriction;Coupled;Coupling;Data;design;Development;digital twin;Economic Burden;effective therapy;Elements;Excision;fibrosing agent;Fibrosis;Foundations;Frequencies;Functional disorder;Future;Goals;Growth Factor;Heart;Heart Diseases;Heterogeneity;human data;Hypertrophy;Immunohistochemistry;improved;in silico;In Vitro;in vivo;individualized medicine;inhibitor;insight;Interdisciplinary Study;Intervention;Ischemia;Kidney Failure;Knowledge;lower urinary tract symptoms;male;Mechanics;Medical;Medical Research;men;microCT;Modeling;multimodal data;muscle degeneration;muscle form;Neurons;nintedanib;novel;novel therapeutic intervention;Obstruction;Operative Surgical Procedures;Organ;Outcome;Pathway interactions;patient response;Patients;Periodicity;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Physics;predicting response;pressure;Prior Therapy;Process;prostate enlargement;prostate surgery;prostration;psychologic;Pulmonary Fibrosis;Quality of life;Rattus;Recovery;Recovery of Function;Reperfusion Injury;Research;Resistance;response;Rodent Model;Role;role model;side effect;simulation;Smooth Muscle;Smooth Muscle Myocytes;sound;Structure;surgery outcome;tadalafil;Testing;Therapeutic;Time;tool;Translating;treatment effect;treatment response;treatment strategy;Urethra;Urinary tract infection;Urodynamics;Work

PROJECT_TITLE: A Digital Twin for Designing Bladder Treatment informed by Bladder Outlet Obstruction Mechanobiology (BOOM)


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Kidney Disease;Microbiome

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: PROJECT NARRATIVE Constipation is one of the most prevalent gastrointestinal disorders in patients with chronic kidney disease (CKD) and has been associated with their adverse kidney and cardiovascular outcomes; however, little is known about the effects of constipation treatment on clinical outcomes nor on outcome-related biochemical and microbiological parameters in patients with CKD. We aim to test the feasibility of delivering an intervention with constipation treatment and determine its effects on changes in clinical, biochemical, and microbiological parameters in patients with CKD and constipation. The findings of our proposed study will be an important step toward a larger clinical trial to verify the effectiveness of constipation treatment as a novel gut-targeted strategy in the management of CKD, potentially contributing to better clinical outcomes in patients with CKD.

PI_NAMEs: DATTA, SUSMITA ;KOVESDY, CSABA PAL;SUMIDA, KEIICHI  (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acceleration;Albumins;Animals;Benign;Biochemical;Biological;Cardiovascular system;Chronic Kidney Failure;Clinical;Clinical Trials;comorbidity;Constipation;Data;Defecation;Development;Disease Progression;Economic Burden;Effectiveness;effectiveness testing;Electrolyte Balance;Electrolytes;Equilibrium;experimental study;feasibility testing;feasibility trial;Fiber;Fluid Balance;Foundations;gastrointestinal;Gastrointestinal Diseases;Goals;gut microbiota;Homeostasis;Human;improved;Inflammatory;Inflammatory Response;Intake;Intervention;Intestinal Motility;Kidney;Lactulose;laxative;Liquid substance;Mediating;Microbe;microbial;microbiota;Modification;novel;open label;Outcome;Patients;Perception;Pharmaceutical Preparations;Phenotype;Phosphorus;Play;Population;Potassium;Production;prognostic;Quality of life;Randomized;randomized trial;recruit;Research Design;Research Project Grants;Role;Serum;social;Suggestion;Symptoms;targeted treatment;Testing;Therapeutic;Toxin;Uremia;Urine

PROJECT_TITLE: Clinical, Biochemical, and Microbiological Effects of Constipation Treatment in Patients with Chronic Kidney Disease: A Pilot Feasibility Trial

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurosciences;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE Mosquitoes spread pathogens to humans through their behavior of blood feeding and identifying and understanding the neurons that control this behavior would enable new strategies to prevent it. Here, I describe an approach using genomics, transgenic mosquitoes, and behavior studies to identify the neurons that are required for mosquitoes to seek out and bite humans. The identification and genetic targeting of these neurons will create a way to understand what causes the attraction of mosquitoes and open new avenues for its prevention.

PI_NAMEs: SORRELLS, TREVOR  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Area;ATAC-seq;Atlases;Automobile Driving;Behavior;Behavior Control;behavioral study;Biological Assay;Bite;Blood;Brain;Carbon Dioxide;cell type;Cells;Cessation of life;Communicable Diseases;Creativeness;Cues;Culicidae;Data;Data Set;Dengue;design;Disease;Enhancers;Face;feeding;Feeding behaviors;Foundations;Gene Expression;Genetic;genetic effector;Genetic Enhancer Element;genetic manipulation;Genomics;Goals;Hand;Human;Human Bites;improved;Individual;innovation;insight;interest;Intervention;Knowledge;Malaria;Maps;Methods;mosquito-borne;Mosquito-borne infectious disease;multiple omics;neural;neural circuit;Neurobiology;neurogenetics;neuronal circuitry;Neurons;Neurosciences;novel strategies;optogenetics;Parasites;pathogen;Peripheral;Postdoctoral Fellow;prevent;Prevention;response;Role;Sensory;sensory integration;sensory stimulus;sensory system;Signal Transduction;single-cell RNA sequencing;Stimulus;success;Techniques;Testing;Time;tool;transcriptome;Transgenic Organisms;transmission process;vector control;Vertebrates;Virus;Work;Yellow Fever;Zika Virus

PROJECT_TITLE: Identification of mosquito brain neurons that drive blood-feeding behavior


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

ORG_CITY: PORTLAND

ORG_DEPT: BIOLOGY

ORG_NAME: PORTLAND STATE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative:  The mechanism by which DNA replication completes is essential to genome stability, and is a driver of metastasis when mutated in cancers. We have identified genes that are synthetic lethal for bacteria mutated in completing replication. Therefore, extending these results to characterize the mechanism by which DNA replication completes in eukaryotes will likely to identify novel genes that can be targeted for cancer therapeutics.

PI_NAMEs: COURCELLE, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Bacteria;Bacterial Genome;Bacterial Proteins;Biological Assay;BRCA2 gene;cancer therapy;Cell division;Cell Physiology;Cell Separation;Cell Survival;cell type;Cells;Chromosomal Instability;chromosome replication;Chromosomes;Clinical;Complex;Data;Detection;Development;DNA;DNA biosynthesis;DNA replication fork;Double Strand Break Repair;Enzymes;Escherichia coli;Eukaryota;Eukaryotic Cell;Event;Gel;gene product;Genes;Genetic Recombination;Genome;genome integrity;Genome Stability;Genomic Instability;Growth;High-Throughput Nucleotide Sequencing;Homologous Gene;homologous recombination;Human;Human Chromosomes;Human Genome;Impairment;In Vitro;inhibitor;Lethal Genes;Malignant Neoplasms;Mammals;Maps;Microsatellite Instability;Modeling;mutant;Mutate;Mutation;Neoplasm Metastasis;novel;novel strategies;nuclease;Pathway interactions;Phenotype;Plasmids;Play;Poly(ADP-ribose) Polymerase Inhibitor;prevent;Process;Proteins;Reaction;Resected;Role;S phase;Saccharomyces cerevisiae;Sepharose;Site;Structure;Synthetic Genes;System;Techniques;Therapeutic;Yeasts

PROJECT_TITLE: Eukaryotic Completion of DNA Replication


NIH_SPENDING_CATS: Neurosciences;Nutrition

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: This proposal, centered on AgRP hunger neurons, investigates circadian control of AgRP neurons and hunger (Aim 1), reciprocal interactions between AgRP neurons and the hypothalamic-pituitary-adrenal glucocorticoid (HPA) axis (Aim 2), and finally regulatory links between circadian control of AgRP neurons and the HPA axis. These studies will determine the mechanism by which eating is prompted to occur at the optimal time of day, how the stress hormone, corticosterone, activates AgRP neurons and if this is responsible for metabolic disease associated with Cushing’s syndrome and chronic stress, and finally how fasting causes adaptive activation of the HPA axis.

PI_NAMEs: LOWELL, BRADFORD B (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Address;Adrenal Glands;Automobile Driving;Blood;Body Temperature;Brain;brain based;Chickens;Chronic stress;circadian;circadian regulation;Circadian Rhythms;Corticosterone;Corticotropin;Cues;Cushing Syndrome;Darkness;Disease;Disinhibition;Eating;egg;Electrophysiology (science);energy balance;Energy Metabolism;Enteral Feeding;epigenomics;falls;Fasting;Feedback;feeding;Feeding behaviors;follow-up;Food;Future;Genetic Transcription;Glucocorticoids;Grant;Hormones;Hunger;Hypothalamic structure;in vivo;increased appetite;inhibitory neuron;insight;Jet Lag Syndrome;Light;Link;mental state;Metabolic;Metabolic Diseases;Monitor;Motivation;Motor Activity;Mus;neural;neural circuit;Neurons;optogenetics;Outcome;Phase;Physiological;Pituitary Gland;Play;prevent;Process;Regulation;Reporting;response;restoration;Role;Schedule;Sensory;Signal Transduction;Stress;System;Time;Work

PROJECT_TITLE: AgRP neurons: circadian control and interactions with the HPA axis

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because our ability to diagnose and treat neurodegenerative disorders is critically dependent on fundamental understanding of cellular and molecular mechanisms of neurodegeneration in vivo. In an intact brain, neurodegeneration likely involves both intrinsic and extrinsic mechanisms. Research described in this proposal will uncover new and potentially evolutionarily conserved mechanisms governing these processes. If successful, it will have a positive impact on informing the understanding and treatment of neurodegenerative disorders.

PI_NAMEs: GUO, SU  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Address;Age;Aging;Angiotensin II;Angiotensins;Animals;Antibodies;Apoptosis;Basic Science;blood pressure regulation;Blood Vessels;Brain;Brain Diseases;candidate identification;cell type;Cells;chemical genetics;Chemicals;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Development;Diagnosis;Disease;disease model;Dopamine;dopaminergic neuron;Drug usage;Etiology;Fishes;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gaucher Disease;Genes;Genetic;glucosylceramidase;Goals;Health;high throughput screening;Human;Hypertension;Image;imaging modality;Immune;Impairment;In Situ;in vivo;Induced Neurons;inhibitor;Injury;insight;interest;Invertebrates;Knock-out;Knowledge;Ligands;men;Metronidazole;Microglia;microscopic imaging;model organism;Modeling;Molecular;Molecular Genetics;Nerve Degeneration;Nervous System;Nervous System Physiology;neural;Neurodegenerative Disorders;Neuroglia;neuron loss;Neurons;neuropathology;neuroprotection;Neurosciences;Nitroreductases;Outcome;Parkinson Disease;Pathway interactions;Pattern;Peptidyl-Dipeptidase A;Process;Public Health;Reaction;receptor;Renin;Renin-Angiotensin System;Reporter Genes;Research;Resolution;Rodent;Role;Signal Pathway;Signal Transduction;small molecule;Sodium Chloride;spatiotemporal;Stains;Strategic Planning;superresolution microscopy;System;Testing;transcriptome sequencing;Transgenic Organisms;United States National Institutes of Health;Vascular System;Vertebrates;Whole Organism;Zebrafish

PROJECT_TITLE: Mechanisms of renin-angiotensin signaling in programmed and insult-induced neuronal death

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative The focus of this R35 renewal application is the continuation of our dedicated research on the role of the mutations of chromatin and chromatin’s modifying machineries in human malignancies, specifically COMPASS and BAP1. These epigenetic factors have been categorically demonstrated to be involved in different forms of cancer, and therefore, the study of their molecular function is critical to the development of targeted therapeutics of these cancers. The funding from this R35 will secure the translational path bringing the treatments under study to the clinic which will have a direct and positive outcome on improving the patients’ prognoses and outcomes.

PI_NAMEs: SHILATIFARD, ALI  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: base;Biochemical;Biological Models;Cancer Etiology;cancer therapy;Cataloging;Cells;Chicago;Chromatin;Chromatin Remodeling Factor;Clinic;Clinical;Clinical Trials;Collaborations;Complex;Dedications;Deubiquitinating Enzyme;Development;Developmental Gene Expression Regulation;Diffuse intrinsic pontine glioma;Endogenous Factors;Enhancers;Epigenetic Process;Equilibrium;Family;Funding;Gene Expression Profile;Gene Expression Regulation;Goals;Grant;H3 K27M mutation;Histones;Human;improved;inhibitor;Laboratories;Malignant Neoplasms;Medicine;MLL gene;Molecular;Mutation;normal aging;Outcome;Pathogenesis;Pathway interactions;patient prognosis;Pediatric Hospitals;Positioning Attribute;Property;Proteins;Reagent;Regulation;Research;Role;Secure;Somatic Mutation;Structure;targeted treatment;Testing;tool;ubiquitin isopeptidase

PROJECT_TITLE: Mutations of Chromatin and its Modifying Machineries in Malignancies


PHR: The goal of the HIV and Alcohol Research center focused on Polypharmacy (HARP) is to design and implement effective personalized treatments for people aging with HIV who are harmed by unhealthy alcohol use and polypharmacy. We will: 1) develop summary estimates of personal health risk based on alcohol and medication exposures and on genetics; 2) pilot risk messages as part of a larger behavioral intervention; 3)use “big data” approaches to identify medications in the context of polypharmacy that might be repurposed to treat alcohol use disorder or prevent alcohol associated liver disease; and 4) pilot the use of these medications in people aging with HIV with Alcohol Use Disorder.

PI_NAMEs: JUSTICE, AMY CAROLINE (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Aging;alcohol abuse therapy;Alcohol consumption;alcohol measurement;alcohol misuse;alcohol prevention;alcohol research;alcohol response;alcohol risk;alcohol use disorder;Alcoholic Liver Diseases;Alcohols;Anti-Retroviral Agents;behavior change;Behavior Therapy;Behavioral;Big Data;Biological Markers;candidate identification;cohort;Collaborations;Communication;Complex;Consumption;Data;Data Analytics;Department of Energy;design;Dose;drinking;drug repurposing;Effectiveness;Electronic Health Record;Elements;experience;Family;frailty;Funding;Genetic;Goals;Health;Health behavior change;Healthcare;High Performance Computing;HIV;Individual;Intervention;Intervention Studies;Laboratories;Link;Literature;Liver Cirrhosis;Liver diseases;Measures;Medical;Metformin;Modeling;Motivation;motivational enhancement therapy;National Institute on Alcohol Abuse and Alcoholism;Outcome;patient response;Patient Self-Report;Patients;personalized intervention;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacists;phosphatidylethanol;Physiological;Pioglitazone;Polypharmacy;Prazosin;Predisposition;Provider;response;Risk;Risk Assessment;Risk Factors;Safety;Selection for Treatments;Series;skills;substance use;Systems Biology;theories;Toxic effect;treatment response;United States Food and Drug Administration;Variant;Verapamil;Veterans

PROJECT_TITLE: The HIV and Alcohol Research center focused on Polypharmacy (HARP)


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Data Science;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Substance Misuse

PROJECT_TERMS: Address;Aging;Alcohol consumption;alcohol research;Alcohols;analytical method;Artificial Intelligence;Authorship;Behavioral;Biological Markers;Biometry;career development;Caring;Clinical;cohort;Cohort Studies;Collaborations;Common Data Element;Communication;Data;data access;Data Analytics;data cleaning;data management;data sharing;Data Sources;data standards;Development Plans;diverse data;Drug Prescriptions;Education;Electronic Health Record;Ensure;experience;Extended Family;Family;Funding;Genetic;Goals;Health;Healthcare;Healthcare Systems;High Performance Computing;HIV;HIV Infections;indexing;Individual;Infrastructure;International;Intervention Studies;Leadership;Libraries;Machine Learning;Medical;Methodology;Methods;Mission;Monitor;motivational enhancement therapy;National Institute on Alcohol Abuse and Alcoholism;Observational Study;Outcome;Peer Review;Persons;Pharmaceutical Preparations;Phenotype;Polypharmacy;Positioning Attribute;Procedures;Productivity;programs;Protocols documentation;Publications;Research Design;Research Personnel;Research Project Grants;Resources;Risk;Role;Seasons;Services;Statistical Methods;substance use;Surveys;Training;translational study;United States National Institutes of Health;Validation;Veterans;Veterans Health Administration

PROJECT_TITLE: Administration and Data Analytic Core


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: NARRATIVE Human B cells actively recombine and mutate their DNA in a controlled fashion to generate a diverse pool of antibodies to defend our bodies from the numerous harmful pathogens we encounter, while the same mutation mechanism can cause lymphoma cancer when it goes awry. Previous evidence suggests that DNA folding and nuclear organization may regulate the mutation mechanism, but how the DNA organization varies between different B cell states in human tissue and between normal and cancer cells are largely unknown. Here we use our new imaging technology to address these important questions of B cell development and lymphoma.

PI_NAMEs: SCHATZ, DAVID G. (contact);WANG, SIYUAN

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: 3-Dimensional;Address;Affect;Antibodies;Antibody Affinity;Antibody-mediated protection;Architecture;B-Cell Development;B-Cell Lymphomas;B-Lymphocyte Subsets;B-Lymphocytes;Biology;cancer cell;Cell Line;Cell Lineage;cell type;Cells;Chromatin;Chromatin Loop;Chromosomal translocation;Chromosomes;cohesion;Complex;Development;DNA;DNA Folding;Elements;Enhancers;Environment;Exhibits;Future;Gene Expression;Generations;Genetic Transcription;Genome;Genomic Instability;Genomic Segment;Genomics;Human;human tissue;Image;Imaging technology;Immune response;Immunobiology;Immunoglobulin Gene Rearrangement;Immunoglobulin Somatic Hypermutation;Immunoglobulins;Immunology;In Situ;Individual;insight;Investigation;Length;Link;Lymphoma;Lymphoma cell;Malignant - descriptor;Malignant Neoplasms;Mammalian Cell;Methods;multiplexed imaging;Mutate;Mutation;Normal Cell;novel imaging technology;novel strategies;Nuclear;Nuclear Lamina;Nuclear Pore;Nuclear Pore Complex;Oncogenic;Oncology;Organelles;pathogen;permissiveness;Phase;Point Mutation;Positioning Attribute;Predisposition;Process;programs;Property;Research;Resistance;Resolution;RNA;Role;Sampling;single molecule;Site;Structure;Structure of germinal center of lymph node;Techniques;Technology;Testing;Three-dimensional analysis;Tissue Sample;Tissues;Tonsil;tumorigenesis;Vaccines;Work

PROJECT_TITLE: Genome Architecture in Human Germinal Center B Cell Development, Malignancy, and Somatic Hypermutation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(70)R]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Activity;Prevention

ORG_CITY: CLIFTON PARK

ORG_NAME: IPACES, LLC

PHR: PROJECT NARRATIVE The iPACES is an interactive Physical and Cognitive Exercise System, innovated to make engaging and effective exercise, affordable and portable for in-home use by patients with neurological conditions at risk for cognitive challenges, in this case tailored for those with Parkinson’s Disease, many of whom are motivated to be proactive in preserving brain health in the fight against cognitive decline toward dementia. Pilot studies of iPACES found significant benefits after just three months of in-home pedaling with an under-desk pedaler that controlled progress down a virtual bike path in a tablet-based videogame that challenges memory for tagging neighborhood errands or tourist destinations. If prior promising findings of cognitive benefit are confirmed in the proposed multi-site clinical trial with Parkinson’s, then we would aim to make this novel neuro-exergame, more widely available to patients, families and health care providers, to add one more tool to curb cognitive decline, preserve brain health and deter dementia.

PI_NAMEs: ANDERSON-HANLEY, CAY ;ARCIERO, JOHN P.;ARCIERO, PAUL J;CLARK, SEAN ;GILLEN, ROBERT WILLSON (contact);MERRILL, DAVID ARTHUR;MOLHO, ERIC STEVEN;PANOS, STELLA E;PETROSSIAN, MELITA ;SAULNIER, EMILIE

PROGRAM_OFFICER_NAME: FORBES, JESSICA CARLENE

PROJECT_TERMS: Adherence;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;archive data;Attention;Behavioral;brain health;Caregivers;Clinical Trials;Cognitive;cognitive benefits;Cognitive remediation;commercialization;comparative efficacy;Computer software;coral;Data;data archive;data integration;Databases;Decision Making;Dementia;Destinations;Development;Diagnosis;digital;digital treatment;Disease;effective intervention;efficacy evaluation;Electronics;Enrollment;executive function;Exercise;exergame;experience;Family;Feedback;fighting;follow-up;foot;Funding;General Population;Goals;Health Insurance Portability and Accountability Act;Health Personnel;Home;Image;Impaired cognition;improved;Individual;innovation;input device;Intervention;Interview;Legal patent;lifestyle intervention;Maintenance;Marketing;Memory;Methodology;Mexico;mild cognitive impairment;Monitor;Motivation;Motor;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Multi-Institutional Clinical Trial;Neighborhoods;Neurodegenerative Disorders;Neurologic;neuropathology;Neuropsychology;Nonpharmacologic Therapy;Notification;novel;older adult;Operative Surgical Procedures;Parkinson Disease;Pathway interactions;Patients;Performance;Periodicals;Pharmaceutical Preparations;Phase;phase 2 study;Physical activity;Physical Exercise;Pilot Projects;pilot test;pilot trial;Placebos;Play;Population;portability;Postdoctoral Fellow;Preparation;preservation;Prevalence;prevent;Prevention;prototype;provider networks;Psyche structure;Publishing;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;remediation;remote assessment;Research;Risk;Short-Term Memory;Site;skills;smart watch;software systems;Symptoms;System;Tablets;tool;Training;Update;usability;Video Games;virtual;virtual coach;virtual reality;Visuospatial;Work

PROJECT_TITLE: Neuro-exergaming for the Prevention and Remediation of Decline due to Parkinson's Disease: Clinical Trial of the Interactive Physical and Cognitive Exercise System (iPACES v3)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-C(10)B]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Dissemination and Implementation Research;HIV/AIDS;Patient Safety;Prevention;Substance Misuse

PI_NAMEs: HSIEH, EVELYN  (contact)

PROJECT_TERMS: Address;Adherence;Aging;Alcohol consumption;alcohol misuse;alcohol research;Alcohols;Area;Assessment tool;Behavior;behavior change;Behavioral;behavioral health;Clinical Pharmacists;Communication;Communities;Counseling;Data;Data Analyses;Data Analytics;data management;design;Development;dissemination science;diversity and equity;Educational Materials;Elements;Ensure;Ethical Issues;Ethnic Origin;experience;Exposure to;Faculty;Feedback;Foundations;Genetic Risk;Goals;Health;Health behavior;Health behavior change;Health Personnel;HIV;implementation science;improved;Individual;instrument;International;Intervention;Intervention Studies;Interview;literacy;Manuscripts;mathematical ability;Medical;member;Methodology;Methods;Modeling;motivated behavior;Motivation;motivational enhancement therapy;multidisciplinary;Outcome;Participant;Patient Education;patient oriented;Patient Selection;Patients;Performance;personalized intervention;Persons;Pharmacogenomics;Pilot Projects;Polypharmacy;Postdoctoral Fellow;posters;Productivity;programs;Provider;Race;Readability;remediation;Research;Research Design;Resources;Review Literature;Risk;Risk Estimate;Science;Series;shared decision making;skills;Structure;Subgroup;Suggestion;Techniques;Terminology;tool development;Training;Translating;Work

PROJECT_TITLE: Risk Communication Core