ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Our preliminary data suggest that a small family of druggable molecules (Nr4a1-3) can regulate both inappropriate B cell responses to “self” and appropriate antibody responses to vaccines. In this proposal, we aim to define the significance and mechanisms of these effects. This will pave the way for developing new therapeutics to target the Nr4a family in order to suppress inappropriate autoimmune B cell responses (in diseases such as lupus and multiple sclerosis) and to optimize protective antibody responses to vaccination.

PI_NAMEs: ZIKHERMAN, JULIE  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Acute;Address;Affinity;Agonist;Alleles;antagonist;Antibody Response;Antigens;Architecture;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactive B cell;B cell differentiation;B cell repertoire;B-Cell Activation;B-Lymphocytes;Bacterial Artificial Chromosomes;Base Sequence;Binding;Biology;c-myc Genes;Chronic;Clone Cells;Coupled;Data;Defect;Development;Disease;DNA Binding Domain;Enzyme-Linked Immunosorbent Assay;Exhibits;expectation;Family;Family member;Feedback;Gene Expression;gene repression;Genes;genetic approach;Genetic Transcription;genome-wide;Goals;Grant;humoral immunity deficiency;Immune;Immune response;Immunity;Knowledge;Ligands;Lupus;Lymphocyte;Masks;Mediating;member;Modeling;Molecular;Multiple Sclerosis;Mus;novel;novel therapeutics;NR4A2 gene;Nuclear Hormone Receptors;Nuclear Receptors;Orphan;Peripheral;Play;preservation;Process;programs;Radiation Chimera;recruit;Reporter;Reporting;Repression;response;restraint;Role;Signal Transduction;single-cell RNA sequencing;small molecule;Stains;Structure of germinal center of lymph node;T-Lymphocyte;Testing;Therapeutic;transcription factor;unpublished works;Vaccination;Vaccines

PROJECT_TITLE: Nuclear Receptors in B Cell Tolerance and Humoral Immune Responses

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Heat is a potent environmental and physiological influence on human health: whether in the form of heat illness and exhaustion, or in the form of fevers which we frequently experience in infection. With changing climates and global dissemination of disease, it is ever more critical to understand how heat regulates human biology at the cellular and subcellular level. This proposal investigates how biomolecular condensates and heat shock proteins—two classes of molecular entities that help cells adapt to heat—may enable key human cell types, including immune cells, to sense and respond to heat shock and fever.

PI_NAMEs: LIN, KYLE MATTHEW (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Affect;Affinity;Animals;Area;Behavior;Binding;Biochemical;Biological Models;Biology;Cell Line;cell type;Cells;Cellular biology;Cessation of life;Circadian Rhythms;climate change;Collaborations;Complement;Cyanobacterium;Disease;Environment;Eukaryota;Event;exhaustion;experience;extreme heat;feeding;Fever;Generations;Genetic Transcription;Growth;Health;Heat shock proteins;Heat Stroke;Heat-Shock Response;Homeostasis;Human;Human Biology;Human Cell Line;Hyperthermia;Immune;Immune system;Infection;Inflammatory Response;Investigation;Ion Channel;Knowledge;Life;Mammalian Cell;Mass Spectrum Analysis;Methods;Microscopic;Microscopy;migration;misfolded protein;Molecular;Molecular Chaperones;molecular scale;mortality;Physical condensation;Physiological;Physiology;Positioning Attribute;protein aggregation;protein expression;protein folding;Proteins;Repression;response;RNA;Sedimentation process;sensor;sex determination;single molecule;stem;Stimulus;Stress;Temperature;Testing;Tissues;Titrations;trafficking;transcription factor;transcriptome sequencing;Translating;warm temperature;Work;Yeasts

PROJECT_TITLE: Investigating Biomolecular Condensates and Heat Shock Proteins in Cellular Responses to Sublethal Heat Shock and Fever

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PI_NAMEs: ABBRUZZESE, JAMES L. (contact)

PROJECT_TERMS: Address;Adult;Affect;Age;anti-cancer research;Cancer Center Support Grant;Cancer Patient;Child;Childhood;Clinical Data;clinical development;Clinical Investigator;Clinical Protocols;Clinical Research;Clinical Research Protocols;Clinical Trials;Clinical Trials Database;Communities;Data;Data Collection;data integrity;data management;Data Reporting;design;Development;Disease;Early Therapeutic-Clinical Trials Network;electronic data;Electronics;Enrollment;Ensure;Ethnic Origin;Female;Gender;Goals;Grant;improved;Infrastructure;Innovative Therapy;Institution;Intervention Trial;Iris;Leadership;Malignant Neoplasms;medical schools;member;Minority;Mission;Monitor;multidisciplinary;National Clinical Trials Network;novel therapeutics;operation;Patient Monitoring;Patient Recruitments;patient screening;Patients;Performance;Process;programs;Protocols documentation;Publications;quality assurance;Race;Reporting;Research;research in practice;Research Personnel;research study;Research Training;Resource Sharing;Safety;Services;sex;Socioeconomic Status;System;Technology;tool

PROJECT_TITLE: Clinical Protocol and Data Management

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the discovery of evolutionarily conserved elements of how humoral immune responses are initiated and regulated by antigen dose and dendritic cell subsets is ultimately expected to revolutionize vaccine design as well as treatment of different allergic, infectious and autoimmune diseases. Thus, this proposal is relevant to the part of NIH's mission that pertains to developing fundamental knowledge that will help to reduce the burdens of human diseases.

PI_NAMEs: IGYARTO, BOTOND Z (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adaptive immune response;Adoptive Cell Transfers;Adoptive Transfer;Allergic Disease;Anti-viral Response;Antibodies;Antibody Affinity;Antibody Response;Antigen Presentation;Antigen Targeting;Antigen-Presenting Cells;Antigens;Autoimmune Diseases;B-Lymphocytes;BLR1 gene;Bone Marrow;Breeding;Cell Culture Techniques;Cells;Chimera organism;Coculture Techniques;Communicable Diseases;Data;Dendritic Cells;Dependence;design;Development;Disease;Dose;Elements;Experimental Models;experimental study;feasibility testing;Flow Cytometry;Generations;Goals;Helper-Inducer T-Lymphocyte;HIV;human disease;Humoral Immunities;Image;Immune response;Immunize;imprint;In Vitro;in vivo;Influenza;Influenza Hemagglutinin;influenza virus vaccine;innovation;Interleukin-6;Knock-out;Knowledge;Langerhans cell;langerin;LoxP-flanked allele;Mission;Molecular;mouse model;Mus;novel;Outcome;Peptide/MHC Complex;Phenotype;Physiologic pulse;Play;Population;prevent;Prevention;Prevention approach;Process;Public Health;rational design;receptor;Regulation;Research;response;Role;Site;Skin;Structure of germinal center of lymph node;System;Testing;Transgenic Mice;United States National Institutes of Health;universal influenza vaccine;universal vaccine;Vaccination;Vaccine Design;Vaccines;Work

PROJECT_TITLE: DC-subset-tailored vaccines


NIH_SPENDING_CATS: Cancer;Neurosciences;Primary Health Care;Rare Diseases

PI_NAMEs: KASTAN, MICHAEL B (contact)

PROJECT_TERMS: Accountability;advanced disease;Advisory Committees;Area;authority;Basic Science;Big Data;Brain Neoplasms;Breast Cancer therapy;Cancer Center Support Grant;Canis familiaris;career;Cell Therapy;Clinical;Clinical Sciences;Collaborations;Communities;community involvement;comparative;Decision Making;design;Development;Disease;Duke Comprehensive Cancer Center;Educational Curriculum;Ensure;Evaluation;Faculty;Faculty Recruitment;Feedback;Fostering;Funding;Future;Goals;health equity;Health system;high risk;improved;Informatics;innovation;Institution;Investments;Leadership;Malignant Neoplasms;Measures;medical schools;Medicine;member;Mentors;Metastatic malignant neoplasm to brain;Oncology;Outcome;outreach;Patient Outcomes Assessments;Performance;Physicians;Population Sciences;Postdoctoral Fellow;pre-doctoral;Primary Care;Primary Care Physician;Process;Productivity;Professional counselor;programs;Recommendation;recruit;Research;Resource Sharing;Risk;Sarcoma;Scientist;senior faculty;Specialist;Strategic Planning;Structure;survivorship;System;Teacher Professional Development;Technology;Training;translational potential;Translational Research;tumor immunology;tumor metabolism;Universities;Urologic Cancer;Vision;Workforce Development

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Infectious Diseases;Inflammatory Bowel Disease

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Narrative The innate immune system is equipped with mechanisms such as Toll-like receptor signaling, nod-like receptor signaling, PYHIN family signaling, RIG-I-like receptor signaling and STING signaling, mediates host defense against infections. However, uncontrolled response and excessive production of cytokines are linked to tissue inflammation and autoimmunity and such as inflammatory disease, colitis and lupus. The proposed project addresses the molecular mechanisms of E3 ligase TRIM29 controlling this response, and will lead to high-impact findings with therapeutic implications.

PI_NAMEs: ZHANG, ZHIQIANG  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;anti-fungal agents;Autoimmunity;Biological Assay;Biological Response Modifiers;Candida albicans;Caspase;Cell Physiology;cell type;Cells;chromatin modification;Chronic;Colitis;Colonic inflammation;cytokine;Dendritic Cells;Disease;DNA mapping;DNA Methylation;Environment;Epigenetic Process;Epithelial Cells;Epithelium;Family;Family member;fungus;gain of function;gastrointestinal;Gastrointestinal tract structure;Gene Expression;Genes;gut inflammation;histone modification;Homeostasis;Host Defense;Human;Hyperactivity;IL18 gene;Immune;immune activation;Immune response;Immune System Diseases;Immunity;in vivo;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;innate immune function;innate immune mechanisms;Innate Immune Response;Innate Immune System;insight;Interleukin-1;Interleukin-1 beta;intestinal epithelium;Intestines;Invaded;Investigation;Knockout Mice;Lead;Link;loss of function;Lupus;Macrophage;Mediating;microorganism;Modeling;Modification;Molecular;mouse model;Mucosal Immune System;multicatalytic endopeptidase complex;Mus;Mycoses;Natural Immunity;novel;novel strategies;pathogen;Pathogenicity;Pathway interactions;Physiological;Play;Positioning Attribute;Production;protein degradation;Proteins;Receptor Signaling;Respiratory System;response;RNA Virus Infections;Role;scaffold;Scaffolding Protein;screening;Signal Transduction;Site;Stimulus;Susceptibility Gene;System;T-Lymphocyte;Testing;Therapeutic;Tissues;Toll-like receptors;tool;treatment strategy;TRIM Family;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Studies of a new checkpoint regulator in the control of intestinal inflammation

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Applications Grants;Appointment;Area;Cancer Center Support Grant;Cancer Control;Categories;Charge;clinical application;Collaborations;college;comparative;Data;Development;Diagnostic;Eligibility Determination;Emerging Technologies;Engineering;Ensure;Environment;Faculty;Faculty Recruitment;flexibility;Funding;Grant;innovation;Institution;Investigation;Investments;Laboratories;Malignant Neoplasms;member;Metastatic malignant neoplasm to brain;Mission;new technology;novel;Oncology;Philanthropic Fund;Pilot Projects;Population Sciences;prognostic;programs;recruit;Request for Applications;Research;Research Personnel;Research Priority;Research Project Grants;Resource Sharing;Resources;Review Committee;Science;Services;Solid Neoplasm;Source;Strategic Planning;Supportive care;survivorship;Techniques;Technology;Therapeutic;Time;tool;Universities;Veterinary Medicine;Vision;working group

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention

PI_NAMEs: PATIERNO, STEVEN R (contact)

PROJECT_TERMS: Address;Advisory Committees;Advocacy;Affect;anti-cancer research;Automobile Driving;base;Biological;Breast Cancer Risk Factor;Cancer Burden;cancer care;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer health disparity;cancer prevention;cancer risk;care systems;Catchment Area;Clinical;clinical practice;Colorectal;Communities;community advisory board;community engagement;community intervention;Community Outreach;community partnership;County;Data Analytics;Death Rate;demographics;Development;Disparity;Dissemination and Implementation;Duke Comprehensive Cancer Center;evidence base;Evidence based intervention;Exhibits;Funding;Grant;Health Disparities Research;health equity;Health Information National Trends Survey;Health Policy;Health system;high risk;Incidence;Infectious Agent;Inflammatory;Intervention;Joints;Knowledge;Lung;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Measures;Medical center;member;Minority Groups;Monitor;Morbidity - disease rate;mortality;NCI Center for Cancer Research;Needs Assessment;neoplasm registry;North Carolina;Obesity;organizational structure;Outcomes Research;Patients;Policies;Population;Population Research;Positioning Attribute;Prostate;Research;Risk Factors;Rural Population;screening;social;Stomach;surveillance data;Surveys;Tobacco;treatment and outcome;Underserved Population;Universities;Work

PROJECT_TITLE: Community Outreach and Engagement


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: TUCSON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE There continues to be a need to improve the quality and quantity of cancer prevention and control research focused on cancer health disparities, as well as to increase the number of scientists from these underrepresented groups. The overall goal of this T32 Cancer Prevention and Control Training Program Addressing Health Disparities is to facilitate the training of a diverse workforce of cancer prevention and control scientists working in underserved populations to reduce cancer health disparities. This multi-faceted, postdoctoral training experience includes the conduct of a specialized research project, didactic instruction, team science experiences, and individual multidisciplinary mentoring teams of highly experienced and peer reviewed research funded faculty investigators, all to assure the development of quality cancer health disparities researchers.

PI_NAMEs: BADGER, TERRY A (contact);CORONADO, GLORIA D;HARRIS, ROBIN B

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Cancer Control;cancer prevention;health disparity;Training Programs

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Women's Health Research

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  Fragility fractures are common injuries that have direct implications on patient function and mortality. This proposal uses bioresorbable implants to investigate the effects of gradual introduction of micromotion within the fracture callus in the presence of healthy and compromised bone. These findings will provide new insights into the role of mechanotransduction and clinical standards of care, while establishing a research framework for developing and optimizing implant designs that will improve patient outcomes.

PI_NAMEs: HAST, MICHAEL WILLIAM (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: 3D Print;Acceleration;Acute;Advisory Committees;American;Animal Model;Animals;Apoptosis;Bachelor's Degree;Biocompatible Materials;Biological;Biological Assay;Biological Process;Biology;Biomechanics;Biomedical Engineering;bone;Bone callus;Bone Diseases;bone fracture repair;bone healing;bone quality;Bone remodeling;career;career development;Caring;Cells;Cellular Assay;Cellular biology;Clinical;Complex;Custom;Data;design;Development;Devices;Disease;Doctor of Philosophy;Educational workshop;efficacy testing;Engineering;Environment;Faculty;Failure;Femur;follow-up;Fracture;fragility fracture;Funding;Future;Gene Expression;Glycolates;Goals;Grant;healing;Healthcare;Histology;Home;Hybrids;Image;Immunohistochemistry;Implant;implant design;improved;Injury;insight;Institution;Interdisciplinary Study;Internal Fixators;Intervention;Journals;Knowledge;Laboratories;Laboratory Research;Learning;life span;mechanical properties;Mechanics;mechanotransduction;Medical Imaging;meetings;Mentors;metallicity;Metals;microCT;Mind;Mission;Modeling;Molecular;Molecular Biology;Molecular Profiling;mortality;Motion;Musculoskeletal;Musculoskeletal Diseases;novel;Operative Surgical Procedures;Orthopedics;osteoblast proliferation;Osteoclasts;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;osteoporotic bone;Osteotomy;Ovariectomy;Patient-Focused Outcomes;Patients;Peer Review;Pennsylvania;pharmacologic;Positioning Attribute;prevent;Process;professor;Radiation;Radiation induced damage;Rattus;repaired;Research;Research Assistant;Research Personnel;Role;sample fixation;Services;Site;skills;Structure;symposium;Techniques;Testing;Thermodynamics;Time;timeline;Tissue Engineering;tool;Training;Trauma;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Modifying fragility fracture healing using a gradient-based mechanotransduction fixation approach

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Biotechnology;Digestive Diseases;Immunization;Immunotherapy;Inflammatory Bowel Disease;Nanotechnology;Rheumatoid Arthritis

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Current treatments for chronic inflammatory conditions such as rheumatoid arthritis and inflammatory bowel disease utilize manufactured antibodies to neutralize key inflammatory cytokines, but they possess limitations arising from the need for repeated injections, including sensitization to the biologic drug. In this project, we propose to develop active immunotherapies targeting terminal products of the complement system, which induce a patient to produce their own therapeutic immune responses, potentially solving this issue. This is achieved using innovative supramolecular assemblies of peptides and proteins, which are built in a modular fashion and facilitate the optimization of the strength and quality of the therapeutic antibody response.

PI_NAMEs: COLLIER, JOEL H (contact)

PROJECT_TERMS: Active Immunotherapy;Acute;Anti-Inflammatory Agents;Antibodies;Antibody Response;Arthritis;Autoimmune Diseases;B-Lymphocyte Epitopes;B-Lymphocytes;Biocompatible Materials;Biological;Biological Assay;Biological Products;CD4 Positive T Lymphocytes;Chronic;chronic inflammatory disease;Collaborations;collagen antibody induced arthritis;Complement;Complement 5a;Complement Activation;complement C3d,g;Complement Inactivators;complement system;cytokine;Degenerative Disorder;design;Development;Dimensions;Disease;Dose;experimental study;Flow Cytometry;Functional disorder;Future;Immune response;Immunotherapeutic agent;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Infusion procedures;inhibitor;Injections;innovation;interest;Ischemia;Listeria monocytogenes;Malignant Neoplasms;manufacture;Measures;Mediating;Modeling;Monoclonal Antibodies;mouse model;Mus;nanofiber;nanomaterials;Natural Immunity;Non-Steroidal Anti-Inflammatory Agents;Outcome;Passive Immunization;Passive Transfer of Immunity;Pathogenesis;Patient Compliance;patient population;Patients;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;Pre-Clinical Model;preservation;Property;protein complex;Proteins;receptor;Renal glomerular disease;Reperfusion Therapy;Research;Resistance to infection;response;Rheumatoid Arthritis;Role;Route;Safety;self assembly;Sodium Dextran Sulfate;Structure;T cell response;T-Cell Depletion;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic antibodies;Therapeutic Monoclonal Antibodies;Tissues;tool;Transgenic Mice;Treatment Efficacy;Vertebral column;Work

PROJECT_TITLE: Supramolecular biomaterials for tuning the inflammatory properties of the complement system

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE SUMMARY We propose the continuation of our pre-doctoral and post-doctoral training program on research in Microbiology and Infectious Diseases. The program, which is entitled “Microbes in Health and Disease”, focuses on training basic and clinical scientists in understanding the beneficial and harmful roles of microbes related to human health. The program will have its intellectual and physical hub in an extraordinary new building devoted to microbial sciences that is located in the heart of the University of Wisconsin-Madison campus, where Microbiology training programs have been ranked the best nationally in 2108.

PI_NAMEs: KLEIN, BRUCE STEVEN (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Disease;Health;Microbe

PROJECT_TITLE: Microbes in Health and Disease

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Aberrant high levels and activity of the c-Myc protein play a key role in cancer formation and progression. This study is to elucidate the molecular and cellular mechanisms underlying the regulation of c-Myc protein levels and activity by the deSUMOylating enzyme SENP1, which could yield important insight into how to target the small ubiquitin-like modifier (SUMO) pathway for cancer therapy.

PI_NAMEs: DAI, MU-SHUI ;SEARS, ROSALIE C (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: 3-Dimensional;Affect;Binding;Biochemical;Biology;Breast;Breast Cancer Model;c-myc Genes;Cancer Biology;Cancer cell line;cancer therapy;Cell Cycle Progression;cell growth;Cell Nucleus;Cell Proliferation;Cells;Complex;Consensus;Deubiquitinating Enzyme;Deubiquitination;enzyme activity;Enzymes;Family member;Gene Expression Regulation;Genes;Goals;Growth;Hand;Homeostasis;Human;In Vitro;in vivo;inhibitor;insight;knock-down;Libraries;Life Cycle Stages;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Tumorigenesis;Mediating;Modification;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Normal Cell;novel;novel therapeutics;Nuclear Pore;Oncogenic;Oncoproteins;overexpression;Pathway interactions;Patients;Peptide Hydrolases;Persons;Phosphorylation;Play;Post-Translational Protein Processing;Process;programs;promoter;Proteins;Proteolysis;Proto-Oncogene Proteins c-myc;Regulation;response;Role;screening;Signal Transduction;Site;small molecule;Sumoylation Pathway;System;Testing;Therapeutic;therapeutic target;therapy resistant;Threonine;Tissues;Transactivation;Transcriptional Regulation;tumorigenesis;Ubiquitin;ubiquitin isopeptidase;ubiquitin ligase;ubiquitin-specific protease;Ubiquitination;virtual

PROJECT_TITLE: DeSUMOylation regulation of c-Myc

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: PHOENIX

ORG_NAME: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER

PHR: Project Narrative This program renewal will provide a greater understanding of the pathogenesis of a critical brain network that modulates cognitive function by identifying connectome deficits during preclinical Alzheimer’s disease (AD) so early treatment strategies can be implemented. Proposed studies are relevant to the NIA mission supporting research to define the cellular and molecular biology of dementia at the earliest stage of onset, which provide targets for transcriptionally aided drug discovery at a time when no treatments exist for AD.

PI_NAMEs: MUFSON, ELLIOTT JAY (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Acetylcholine;Affect;age related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease therapy;Amyloid;Amyloid beta-Protein;Animal Model;Anterior;Atrophic;Automobile Driving;basal forebrain;basal forebrain cholinergic neurons;Biological;Brain;Brain Diseases;brain tissue;Case Study;Cell model;Cellular biology;cholinergic;Clinical;Cognitive;cognitive function;Cohort Studies;Complex;connectome;data management;Defect;Dementia;Disease;drug discovery;Drug or chemical Tissue Distribution;Early treatment;Elderly;Event;executive function;FDA approved;Functional disorder;Genetic;Genetic Transcription;Goals;Human;human tissue;Impaired cognition;Impairment;in vivo;Individual;interest;Intervention;Measures;Memory;Michigan;MicroRNAs;mild cognitive impairment;Mission;Molecular;Molecular Biology;multidisciplinary;Nerve Degeneration;Neuroanatomy;Neurobiology;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;neuroinflammation;Neurologic;neuron loss;neuronal circuitry;Neuronal Dysfunction;Neuronal Plasticity;Neurons;neuropathology;Neurotransmitters;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Older Population;Onset of illness;Participant;Pathogenesis;Pathologic;Pathology;Pharmaceutical Preparations;Phase;Play;pre-clinical;Pre-Clinical Model;preservation;prevent;Process;prodromal Alzheimer's disease;Productivity;Program Research Project Grants;programs;Protein Splicing;public health priorities;religious order study;Research;Research Design;Research Project Grants;Research Support;resilience;Role;Route;Scientist;Series;statistics;Stress;Synapses;Syndrome;System;Systems Biology;tau aggregation;tau mutation;tau Proteins;Testing;Therapeutic;Time;Tissues;treatment strategy;Universities;Vulnerable Populations

PROJECT_TITLE: Neurobiology of Mild Cognitive Impairment in the Elderly


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Advisory Committees;Agreement;Alzheimer's Disease;Alzheimer's Disease Core Center;Biocompatible Materials;Blinded;brain tissue;Budgets;Clinical;Communication;Consensus;Data;data exchange;data management;Dementia;Discipline;Doctor of Philosophy;Drug or chemical Tissue Distribution;Elderly;Ensure;Exercise;Freezing;Funding;Funding Agency;Future;Goals;Harvest;Individual;Institution;Laboratory Research;Leadership;Medical center;meetings;member;Michigan;mid-career faculty;mild cognitive impairment;Molecular;Neurobiology;Neurologic;neuropathology;New York;Persons;Positioning Attribute;Program Research Project Grants;programs;Progress Reports;Protocols documentation;Research;Research Personnel;Research Project Grants;Research Support;Resources;Review Committee;Sampling;Scientist;Site;Specimen;statistics;Structure;Universities;Update;Videoconferencing;web page;web site;Work

PROJECT_TITLE: Core A-Administrative and Tissue Distribution


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Nashville

ORG_DEPT: CHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE The trainees participating in the CBI training program are engaged in a number of NIH-supported projects that employ techniques, understanding and tools of chemistry to study a variety of biomedical problems with relevance to the study of human biology, health and therapeutic agent development.

PI_NAMEs: BACHMANN, BRIAN O (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Biology;Chemicals;Training Programs

PROJECT_TITLE: Vanderbilt Chemical Biology Interface Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: MALEK-AHMADI, MICHAEL  (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's Disease Core Center;basal forebrain;Bioinformatics;case-based;Cellular Neurobiology;Chicago;cholinergic;Clinical;Cognitive;Data;Data Analyses;data integration;data library;data management;Data Set;Databases;Diagnosis;Disease Progression;Elderly;Eligibility Determination;Ensure;Exclusion Criteria;experience;Goals;human tissue;Laboratories;Libraries;Link;mild cognitive impairment;Mission;Molecular;Molecular Neurobiology;Network-based;Neurobiology;neuropathology;Pathologic;pre-clinical;Program Research Project Grants;religious order study;Research;Research Design;Research Personnel;Research Project Grants;Resources;Specific qualifier value;Statistical Data Interpretation;statistics;success;Tissue Sample;Tissues

PROJECT_TITLE: Core B - Statistical and Data Management


NIH_SPENDING_CATS: Genetics

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE STATEMENT The long term goal of this project is to gain a detailed molecular understanding of nonsense-mediated mRNA decay (NMD) - a cellular quality control process that monitors mRNA integrity and rapidly clears transcripts harboring a nonsense mutation within their protein-coding region. It is estimated that nonsense mutations represent the underlying cause of ~30% of human genetic diseases, but that nonsense-containing mRNA could, in many cases, produce sufficient amounts of functional protein if either the decay of the transcript by NMD and/or extent of premature translation termination was attenuated. Modulation of NMD therefore presents a formative strategy to expand therapeutic options for individuals with inherited genetic disorders due to nonsense mutations, and efforts to develop such therapies would benefit profoundly from a comprehensive understanding of the molecular mechanisms underlying NMD.

PI_NAMEs: BAKER, KRISTIAN EILEEN (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;ATP Hydrolysis;ATP phosphohydrolase;Attenuated;Binding;Binding Sites;Biochemical;Biological;Biological Process;Biotin;cell type;Cells;Classification;cofactor;Complement;Complex;Coupled;crosslink;Cytoprotection;Data;Data Set;decay acceleration;Defect;Engineering;Ensure;Enzymes;Eukaryotic Cell;Event;Excision;Exclusion;experimental study;Gene Expression;genetic approach;Genetic Diseases;genetic information;Genomic approach;Goals;Hereditary Disease;Human Genetics;Immunoprecipitation;in vivo;in vivo monitoring;Individual;innovation;insight;Label;Left;Length;Link;Mediating;messenger ribonucleoprotein;Messenger RNA;Modeling;Molecular;Monitor;mRNA Decay;mRNA Transcript Degradation;mRNA Translation;mutant;Nature;Nonsense Codon;Nonsense Mutation;Nonsense-Mediated Decay;novel;Open Reading Frames;Pathway interactions;Poly(A)+ RNA;polypeptide;premature;prevent;Process;Production;protein complex;Proteins;Protocols documentation;public health relevance;Quality Control;Rationalization;Reagent;Recycling;Regulator Genes;Research;Ribosomes;RNA;RNA Binding;RNA Decay;RNA-Binding Proteins;Role;Saccharomycetales;Seminal;Sequence Analysis;Signal Transduction;Testing;Therapeutic;Time;tool;Transcript;transcriptome;Translating;Translations;Yeast Model System;Yeasts

PROJECT_TITLE: Recognition and degradation of mRNA by nonsense-mediated decay.

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: COUNTS, SCOTT E (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease therapeutic;Amyloid;Antibodies;Automobile Driving;Basal Nucleus of Meynert;Binding;Binding Sites;Biochemical;Bioinformatics;Biological Assay;Brain;candidate identification;Categories;Cell Nucleus;cholinergic;cingulate cortex;Cognitive;Collaborations;connectome;Data;Deacetylase;Dementia;density;Disease;Disease Progression;Elderly;Epitopes;Evolution;frontal lobe;Functional disorder;Gene Expression Profiling;Glutamates;Goals;Human;Impaired cognition;Inflammation;Inflammatory;insight;laser capture microdissection;Mediating;Messenger RNA;Metabolic;Metabolic Pathway;Metabolism;Methods;MicroRNAs;mild cognitive impairment;miRNA expression profiling;Molecular;Molecular Weight;monomer;mRNA Stability;Nerve Degeneration;nerve supply;Neurobiology;Neurofibrillary Tangles;neuron loss;Neurons;neuropathology;neurotoxicity;novel;Optics;overexpression;Pathologic;Pathology;Pathway interactions;Pattern;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;pre-clinical;Principal Investigator;programs;protein expression;Protein Isoforms;Protein phosphatase;Regulatory Pathway;Reporter;Research;Respiration;RNA Splicing;Sampling;SIRT1 gene;Site;Site-Directed Mutagenesis;spatiotemporal;Spliceosomes;Synapses;Synaptic plasticity;Synaptic Transmission;targeted treatment;tau aggregation;tau expression;tau Proteins;tau-1;tau-protein kinase;Testing;Therapeutic Intervention;Tissues;Transcript;Untranslated Regions;Untranslated RNA;validation studies

PROJECT_TITLE: Project 1 (MSU)-Neurofibrillary tangle evolution in mild cognitive impairment


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

PROJECT_TERMS: Affect;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Amyloid;Animals;Anterior;Anterolateral;Antibodies;Apolipoprotein E;Autopsy;basal forebrain;basal forebrain cholinergic neurons;Basal Nucleus of Meynert;Basic Science;Cells;cholinergic;Cholinesterase Inhibitors;cingulate cortex;Clinical;Cognition;Cognitive;Cohort Studies;Complex;connectome;Data;Defect;Dementia;density;Development;Disease;Disease Progression;Dorsal;Drug Design;Drug Targeting;early detection biomarkers;Elderly;Episodic memory;Event;Evolution;Executive Dysfunction;executive function;Exons;familial Alzheimer disease;frontal lobe;Functional disorder;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Heterogeneous-Nuclear Ribonucleoproteins;Hippocampus;Human;immunocytochemistry;Impaired cognition;Impairment;improved;In Vitro;in vivo;Individual;innovation;Intervention;Laboratories;Libraries;Link;Medial;medial temporal lobe;Memory;Messenger RNA;Metabolic;mild cognitive impairment;Molecular;morphometry;Neocortex;Nerve Degeneration;Nervous System Disorder;Neurobiology;neurofibrillary tangle formation;Neurofibrillary Tangles;neuroimaging;Neurons;neuropathology;neurotransmission;novel;novel marker;Nuclear;Older Population;Onset of illness;Optics;Participant;Pathogenicity;Pathology;Pattern;Pharmaceutical Preparations;Phosphotransferases;Play;Population;Populations at Risk;Post-Translational Protein Processing;pre-clinical;prodromal Alzheimer's disease;Protein Isoforms;Protein Splicing;Proteins;religious order study;Reporting;Ribosomal RNA;RNA metabolism;RNA Splicing;RNA Stability;Role;Series;Sirtuins;Site;spatiotemporal;Spliceosomes;SRSF2 gene;Study Subject;Subgroup;Symptoms;System;tau aggregation;tau expression;tau Proteins;tau-1;Technology;Temporal Lobe;Testing;Tissue Sample;Tissues;transcriptome sequencing;Translating;U1 Small Nuclear Ribonucleoprotein;Untranslated RNA

PROJECT_TITLE: Project 3 (BNI)-Cholinergic alteration in mild cognitive impairment


NIH_SPENDING_CATS: Aging

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative High quality training in public health and aging will prepare trainees to pursue productive careers in research and policy at the intersection of public health, social sciences, and other health sciences. The program is designed to help trainees develop new content and methods that will inform preventive, clinical and policy strategies aimed at improving the health and quality of life of future generations of older adults.

PI_NAMEs: KOBAYASHI, LINDSAY C (contact);MEZUK, BRIANA

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TITLE: Interdisciplinary Research Training on Health and Aging


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This project seeks to identify earlier, and more precisely, which children will develop motor problems later in life in hopes that we can use that information to develop more targeted treatments and create better outcomes for those children. Each year in the United States, 500,000 infants are born preterm (<37 weeks' gestation), putting them at high risk for lifelong neurodevelopmental impairments, including motor disabilities such as cerebral palsy, but we do not yet have a way to predict their individual outcomes and target therapies. This study proposes to investigate a unique, highly valuable cohort of children born very preterm (<30 weeks' gestation) to use data from newborn brain MRI scans and standardized assessments of motor outcomes performed across childhood to build statistical models which accurately predict motor outcomes at the individual level.

PI_NAMEs: CYR, PEPPAR ELIZABETH PEI-PEI (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: 10 year old;37 weeks gestation;Accounting;Advocacy;Age;Anatomy;Anisotropy;Area;Award;Basal Ganglia;Brain;brain magnetic resonance imaging;Brain region;career;Cerebellum;Cerebral Palsy;Child;Childhood;Clinical;clinical risk;cohort;Communication;Corpus Callosum;Corticospinal Tracts;Data;Data Analyses;Dedications;design;Development;Diffusion;Diffusion Magnetic Resonance Imaging;disability;early childhood;Early identification;Environment;experience;extreme prematurity;Face;Functional Magnetic Resonance Imaging;Growth;high risk;high risk population;imaging modality;improved;improved outcome;Individual;individual patient;Infant;Infant Development;Intervention;Investigation;Life;Link;Literature;Long-Term Effects;Longitudinal cohort;Magnetic Resonance Imaging;Measures;Medical;Methodology;Methods;middle childhood;Modality;Modeling;Modification;Motor;Motor Cortex;motor deficit;Motor disability;motor impairment;Movement;MRI Scans;Neonatal;neonatal brain;Neurodevelopmental Disability;Neurodevelopmental Impairment;neuroimaging;Neurologist;Newborn Infant;Outcome;outcome prediction;Patient Care;Performance;personalized predictions;Phenotype;Physicians;Population;predictive modeling;Pregnancy;Premature Birth;Process;prospective;Research;Resolution;Rest;retention rate;Risk;Risk Factors;Scientist;skills;social;Standardization;standardize measure;Statistical Models;Structure;success;System;targeted treatment;Testing;Thalamic structure;Training;United States;white matter;white matter injury;Work

PROJECT_TITLE: Individual Motor Outcome Prediction in Preterm Children Using Neonatal Neuroimaging


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE Sleep is a key process in the maintenance of health; suboptimal sleep contributes to health burden through increased risk for a range of mental health, metabolic, and chronic health outcomes. Environmental exposures, such as air pollution, greenness, and light-at-night, are linked to sleep; due to their ubiquity, modifiable environmental exposures that affect sleep are integral to the promotion of sleep health on a population level. This research aims to address gaps in various aspects of environmental health research on sleep by validating extant mobile health measurement tools for sleep, assessing a possible mediating pathway between an environmental exposure and sleep, and investigating the relationships between multiple environmental exposures and sleep independently and in an exposomic framework.

PI_NAMEs: HU, CINDY ROBIN (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: 18 year old;Accelerometer;actigraphy;Address;Adult;Affect;Agreement;Air Pollution;Anxiety;Arts;Behavior;built environment;Cardiovascular Diseases;Centers for Disease Control and Prevention (U.S.);Chronic;Cognition;cohort;Complex;Development;Diabetes Mellitus;doctoral student;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Health;epidemiology study;experience;Exposure to;Fellowship;Female;fitbit;Future;Geographic Distribution;Geography;Goals;Gold Alloys;graduate school;Green space;Health;Health behavior;health data;health determinants;Health Status;Health Technology;Hour;Human;Humidity;Individual;insight;interest;Investigation;Joints;Light;Link;Location;Longitudinal cohort;Maintenance;male;Measurement;Measures;Mediating;Mediation;men;Mental Depression;Mental Health;Mentorship;Metabolic;mHealth;Neighborhoods;Nurses;Nurses' Health Study;Nursing Students;Obesity;Outcome;Pathway interactions;Patient Self-Report;Performance;Physical activity;physical conditioning;Physiological;Polysomnography;Population;population health;Positioning Attribute;pre-doctoral;Process;Prospective cohort;public health intervention;Public Health Schools;Recommendation;Recording of previous events;Recovery;repaired;Reporting;Research;Resources;Risk;Risk Factors;Role;Science;Seasons;Shapes;Sleep;Sleep Deprivation;sleep health;smartphone application;social;Socioeconomic Status;Source;Temperature;Time;tool;Training;United States;Universities;Validation;walkability;wearable device;Woman;Wrist

PROJECT_TITLE: Environmental Exposures & Sleep in the Nurses' Health Study 3

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: IKONOMOVIC, MILOS D (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;amyloid pathology;Anterior;Attenuated;Autopsy;Basal Nucleus of Meynert;Binding;Biochemistry;Biological Assay;Brain;Brain region;Case Study;cholinergic;cingulate cortex;Clinical;Cognition;Cognitive;cognitive testing;Collaborations;connectome;cytokine;Data;Dementia;Denervation;Disease;Disease Progression;Down-Regulation;Drug Targeting;Elderly;enzyme activity;Enzyme-Linked Immunosorbent Assay;Evaluation;Exhibits;frontal lobe;Functional Magnetic Resonance Imaging;Glutamates;Goals;Image;imaging study;Immunofluorescence Microscopy;Immunohistochemistry;Impaired cognition;In Vitro;Inflammatory;insight;Ligands;Liquid Chromatography;Measures;Messenger RNA;mild cognitive impairment;Molecular Conformation;Morphology;nerve supply;neural circuit;Neurobiology;neurochemistry;neuroinflammation;Neuronal Plasticity;neuropathology;Neuropsychology;neurotransmitter release;Neurotransmitters;new therapeutic target;novel;novel therapeutics;Onset of illness;Pathology;Pharmacotherapy;Positron-Emission Tomography;pre-clinical;preservation;Presynaptic Terminals;prevent;prodromal Alzheimer's disease;Proteins;Proteomics;religious order study;resilience;Resistance;response;Study Subject;Synapses;Synaptosomes;System;tandem mass spectrometry;tau aggregation;tau Proteins;Testing;Tissues;Tracer;Translational Regulation;Universities;Up-Regulation

PROJECT_TITLE: Project 4 (Pitts)-Cholinergic and amyloid alteration in mild cognitive impairment


ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Research proposed here builds on a new way by which the amount of HIV-1 produced by infected cells is controlled by certain proteins called chemokines released by human immune cells. Interestingly, the genes for this chemokine (CCL2) and its receptor (CCR2) have been previously shown to influence HIV-1 disease – but it was not known why. This application proposes to understand precisely how such chemokines influence HIV disease and develops a foundation for new drugs that can block HIV by targeting the chemokine.

PI_NAMEs: PRASAD, VINAYAKA R. (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Actins;Adaptor Signaling Protein;Affect;antagonist;Binding;CCL2 gene;CD4 Positive T Lymphocytes;Cells;chemokine;Cohort Studies;Cytoskeleton;Cytosol;Data;Defect;Disease;Disease Progression;drug candidate;drug development;Drug Targeting;Electron Transport Complex III;Enhancers;Event;experimental study;extracellular;F-Actin;fitness;Foundations;gag Gene Products;Genes;Genetic Polymorphism;Genotype;Goals;Hela Cells;HIV;HIV Infections;HIV Seronegativity;HIV-1;Human;Human Volunteers;Immune;in vitro testing;in vivo;Individual;Investigation;Knock-out;Lead;Macrophage;Mediating;Mediator;Membrane;Molecular Conformation;mutant;Mutation;Neck;new therapeutic target;novel;novel therapeutics;Participant;Peripheral Blood Mononuclear Cell;Phosphorylation;Phosphorylation Site;Plasma;Post-Translational Protein Processing;Predisposition;Production;Proteins;Publishing;receptor;recruit;Regulation;Reporting;Research;Risk;Role;Serine;Signal Pathway;Signal Transduction;Surface;Testing;Tyrosine;Tyrosine Phosphorylation;Virion;Virus;Work

PROJECT_TITLE: CCL2-CCR2b signaling in HIV-1 fitness and disease; Role of host genetic polymorphisms

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project narrative. Infectious diseases and sepsis still remain a major threat to human life. Inflammasome sensing of PAMPs and DAMPs has tremendous implications for human infectious diseases and inflammatory diseases such as sepsis. By uncovering new mechanisms involved in the regulation of inflammasome sensing of PAMPs, the findings from this study could offer new immunomodulatory targets to boost antimicrobial responses and mitigate detrimental inflammatory responses during sepsis.

PI_NAMEs: RATHINAM, VIJAY  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Address;Anti-Bacterial Agents;antimicrobial;Autoimmunity;Bacteria;Bacterial Infections;beta-galactoside;Binding;Binding Proteins;Biological Assay;Burkholderia;carbohydrate binding protein;carbohydrate receptor;Carbohydrates;CASP1 gene;Caspase;Cell Death;cell type;Cells;Co-Immunoprecipitations;Communicable Diseases;Confocal Microscopy;Coupled;Cytosol;Disease;DNA;endosome membrane;Endosomes;Event;Excision;Family;Francisella;Galactose Binding Lectin;Galectin 3;Glycoproteins;Gram-Negative Bacteria;guanylate;Homeostasis;Host Defense;Human;IL18 gene;Image;Immune;Immunologic Surveillance;immunoregulation;Impairment;In Vitro;in vivo;Infection;Inflammasome;Inflammatory;Inflammatory Response;insight;Interleukin-1 beta;Knockout Mice;Knowledge;Label;Licensing;Life;Link;Lipopolysaccharides;Lytic;Macromolecular Complexes;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane;microbial;Modeling;Molecular;Monitor;Mus;mutant;pathogen;pathogenic Escherichia coli;Pathologic Processes;Pathway interactions;Pattern;Peptide Hydrolases;Physiological Processes;Play;Polysaccharides;Process;Proteins;Regulation;repaired;response;Role;Salmonella;sensor;Sepsis;Series;Shapes;Side;Signal Transduction;Specificity;Translational Activation;Trauma;ultra high resolution;Vacuole;VDAC1 gene;Vesicle;Virus Diseases

PROJECT_TITLE: Cytosolic Immune Surveillance During Bacterial Infections


NIH_SPENDING_CATS: Cardiovascular;Neurosciences

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative: The importance of mechanosensitive channels to human health is underscored by the association of many disease states with compromised mechanosensation, including atrial fibrillation, muscular degeneration, arrhythmias, polycystic kidney disease, and numerous neural diseases. Therefore, it is the goal of this work is to understand both generalizable and cell type specific roles of mechanosensation in regulating gene expression, cellular motility, and cell-to-cell communication.

PI_NAMEs: STRATMAN, AMBER NICOLE (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: 3-Dimensional;Affect;Arrhythmia;Astrocytes;Atrial Fibrillation;Biological;Biological Assay;blood pressure regulation;Cell Communication;cell motility;cell type;Cells;Communication;Communities;Complex;Data;Disease;Endothelial Cells;Environment;Equilibrium;Gene Expression;Goals;Health;Human;In Vitro;Individual;intercellular communication;interest;Ions;Knowledge;Morphogenesis;Movement;Muscle;neural;Normal tissue morphology;Osmosis;Pattern;Play;Polycystic Kidney Diseases;programs;Proteins;Regulation;Research;Role;Second Messenger Systems;Signal Transduction;Smooth Muscle Myocytes;Stretching;Tissue Model;Tissues;Touch sensation;Transcriptional Activation;Work;zebrafish development

PROJECT_TITLE: Mechanosensitive mechanisms regulating cellular coordination during tissue morphogenesis and patterning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ORG_CITY: ALBANY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: PROJECT NARRATIVE  MARC at UAlbany seeks to advance the mission of the NIH and the MARC program to increase the diversity of the pool of biomedical researchers working to address today’s most pressing public health concerns. MARC at UAlbany builds on the incredible diversity of the University at Albany undergraduate student body, track record of excellence in health-related biomedical research, and demonstrated institutional commitment to diversity, equity, and inclusion. A structured program of training activities coalesces and augments existing initiatives to offer students traditionally underrepresented in biomedical research careers the individualized team mentorship, academic enhancement, high-impact research experiences, professional skills development, and supportive community necessary for their successful transition into research-focused graduate (Ph.D. and M.D./Ph.D.) training programs.

PI_NAMEs: ALTARRIBA, JEANETTE ;HORMES, JULIA M (contact);WAGNER, CHRISTINE K

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Advisory Committees;Bachelor's Degree;Biomedical Research;Capital;career;CCL7 gene;cultural competence;Degree Completion;Degree program;design;Development Plans;Enrollment;equity, diversity, and inclusion;evidence base;experience;Faculty;Fostering;Funding;Graduate Degree;Individual;information gathering;Interview;Manuscripts;Measurable;Mentors;Mission;Monitor;Outcome;Performance;Process;programs;Qualifying;Readiness;Records;recruit;Research;Research Project Grants;Research Training;Resources;Science;Scientist;Self Efficacy;skills;skills training;social;social capital;Structure;Students;success;symposium;synergism;Training;Training Activity;Training Programs;undergraduate student;Underrepresented Students;Universities

PROJECT_TITLE: MARC at UAlbany

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

PHR: NARRATIVE The University of Oregon Genetics Training Program will train a cohort of PhD students in foundational genetic concepts and quantitative analytical approaches, provide them with skills to pursue fulfilling careers in biomedicine, and prepare them to be conscientious scientific leaders. This program will advance new knowledge in genetics, contribute to a diverse and productive research workforce, and promote a culture of ethical, responsible, and trustworthy science.

PI_NAMEs: GUILLEMIN, KAREN J (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Genetic;Grant;Training

PROJECT_TITLE: Graduate Training Grant in Genetics

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative A complex range of psychosocial (i.e., substance use, depression, and stigma) and structural factors (incarceration, poverty) can contribute to racial disparities in HIV diagnoses, prevalence and outcomes (i.e., viral suppression) among Black men who have sex with men (MSM) living with HIV in the Florida, a population that is hard to recruit into biobehavioral HIV research. The proposed K01 application will support an African-American new and early stage investigator to become an independent health disparities researcher and a leader in interdisciplinary research on examining the intersectionality of public health, substance use and HIV, and syndemic research. Specifically, the outlined project will contribute to the identification of subgroups of Black MSM living with HIV in Florida who could benefit from a shared biobehavioral intervention to improve social support and viral suppression based on their shared characteristics.

PI_NAMEs: CANIDATE, SHANTREL S (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: African American;AIDS prevention;Area;biobehavior;black men who have sex with men;black subgroup;career;Caring;Characteristics;Clinical;Cohort Studies;Collaborations;Complex;cooking;Data;demographics;design;Development;Emotional;Epidemic;experience;Florida;follow-up;Funding;Future;Goals;Health;health care availability;health disparity;HIV;HIV diagnosis;Imprisonment;improved;Interdisciplinary Study;intersectionality;Intervention;Intervention Studies;Interview;Knowledge;Literature;Longitudinal Studies;Longitudinal, observational study;Measures;men who have sex with men;Mental Depression;Mentored Research Scientist Development Award;Mentors;Methods;Modeling;National Institute on Alcohol Abuse and Alcoholism;Outcome;outreach;Participant;Population;Poverty;Prevalence;programs;psychosocial;Psychosocial Factor;Public Health;Qualitative Methods;Qualitative Research;Race;racial disparity;recruit;Reduce health disparities;Registries;Reporting;Research;Research Personnel;Resources;responsible research conduct;Sampling;Scientist;social media;social stigma;Social support;structural determinants;Structure;Subgroup;substance use;syndemic;Testing;theories;Time;Training;Validation;Viral

PROJECT_TITLE: A mixed methods study of syndemic factors associated with social support and viral suppression among Black men who have sex with men (MSM) in Florida".

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: LITTLE ROCK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative High expression of NEK2 mediates myeloma cell survival, drug resistance, and bone destruction and is associated with poor patient outcome. We propose to explore how NEK2 promotes myeloma disease progression. We will also investigate the use of combinational immune therapy to prevent myeloma progression and relapse using primary myeloma samples and in vivo mouse models.

PI_NAMEs: ZHAN, FENGHUANG  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Ablation;anti-PD-1/PD-L1;anti-PD-L1 therapy;Apoptosis;Autologous Stem Cell Transplantation;Behavior;Biochemical;Biological Assay;Biology;bone;cell growth;Cell Survival;Cells;chemotherapy;Chromosomal Instability;Clinical;Complex;cytotoxicity;Data;Deubiquitination;Development;Disease;Disease Progression;Disease remission;Drug resistance;Epigenetic Process;EZH2 gene;FDA approved;Gene Expression Profile;Genes;Genetic;Goals;Hematologic Neoplasms;heparanase;HIF1A gene;high risk;histone methyltransferase;Human;immune checkpoint blockade;immune modulating agents;Immunocompetent;Immunotherapy;improved;In complete remission;In Vitro;in vivo;inhibitor;innovation;insight;Knockout Mice;Link;Malignant Neoplasms;Mediating;Methylation;Modification;mouse model;Multiple Myeloma;Mus;neoplastic cell;Network-based;Newly Diagnosed;NFKB Signaling Pathway;novel;novel therapeutic intervention;novel therapeutics;Numerical Chromosomal Abnormality;Oncoproteins;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;PD-1/PD-L1;PDL1 inhibitors;Pharmaceutical Preparations;pharmacologic;Plasma Cells;prevent;Prevention approach;Probability;Prognosis;programmed cell death ligand 1;Proteasome Inhibitor;Protein-Serine-Threonine Kinases;Proteins;PTEN gene;Relapse;Reporting;Research;Residual Neoplasm;Resistance;response;Role;Sampling;Signal Pathway;Signal Transduction;Solid Neoplasm;Structural Chromosomal Abnormality;Testing;TP53 gene;TRAF6 gene;Transgenic Mice;Transplantation;tumor growth;Tumor Suppressor Proteins;ubiquitin isopeptidase;Ubiquitination

PROJECT_TITLE: Novel NEK2 signaling pathways in myeloma progression

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: At this time of unprecedented growth in scientific discovery and challenges to health, we plan to generate physician scientist leaders to meet the nation’s needs through a training program leading to dual MD and PhD degrees. The program draws on best practices in education and in launching and sustaining careers leading to major research advances and the translation of those discoveries to advance health and combat disease. We seek to train and equip academia, industry and other domains with a superlative and diverse cadre of MD- PhD graduates who will accelerate biomedical progress at the interface of research and clinical medicine.

PI_NAMEs: SCHWARTZ, RUSSELL S;STEINMAN, RICHARD A (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program


NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Anopheles mosquitoes serve as vectors for the parasite causing malaria worldwide. This disease causes one of the most significant health problems worldwide, sickening 228 million people and killing over 405,000 in 2018, 2/3 of which are young children — the most vulnerable demographic. This project seeks to develop genetic technologies that would allow to genetically engineer the mosquito population, with the ultimate goal of reducing disease burden.

PI_NAMEs: BIER, ETHAN  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Affect;Alleles;Animals;Anopheles Genus;Anti-malarials;Biology;burden of illness;Bypass;Child;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Culicidae;Deposition;design;Development;Disease;Disease Outbreaks;disease transmission;DNA cassette;DNA Double Strand Break;Drosophila genus;Drosophila melanogaster;Effectiveness;egg;Embryo;Embryonic Development;Endonuclease I;Endowment;Engineering;Failure;Female;fighting;fitness;Future;Gene Conversion;gene drive system;Generations;Genes;Genetic Engineering;genetic technology;Genome;Germ Lines;Goals;Guide RNA;Health;human pathogen;Immune;Impairment;improved;Inherited;Insect Vectors;Insecta;insertion/deletion mutation;Laboratories;Location;Malaria;Methods;Modification;Morbidity - disease rate;Mosquito-borne infectious disease;Mutation;novel;offspring;Parasites;pathogen;Pathway interactions;Persons;Pesticides;Population;prevent;Process;Production;Property;Public Health;Recycling;repaired;Research;Resistance;resistance allele;response;Technology;Testing;tool;trait;Translations;transmission process;vector;vector mosquito;Work

PROJECT_TITLE: Development of next-generation gene drive technologies for Anopheles population engineering

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Osteoarthritis;Pain Research

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Project Narrative The proposed research is relevant to public health because a better understanding of blood epigenetic patterns in osteoarthritis (OA) is likely not only to give insights into the causes of OA, but also to give rise to new biomarkers to assist physicians and researchers diagnose OA patients and predict how rapidly they will worsen over time. Thus, this proposal is relevant to the part of the NIH's mission that pertains to fostering fundamental creative discoveries, innovative research strategies, and their applications as a basis for ultimately improving health.

PI_NAMEs: JEFFRIES, MATLOCK  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Affect;Age Years;algorithm development;Algorithms;Big Data;biobank;Biological Markers;biomarker development;bisulfite;bisulfite sequencing;Blood;Blood Cells;Blood specimen;Cartilage;Chronic;Chronic disability;Classification;Clinical;clinical application;Clinical Data;clinically relevant;cohort;Creativeness;Data;deep sequencing;Degenerative polyarthritis;Development;Diagnosis;Disease;DNA;DNA Methylation;DNA methylation profiling;Early Diagnosis;economic impact;Environment;epigenetic marker;Epigenetic Process;epigenome;FDA approved;Fostering;Foundations;Future;Genes;Genetic Transcription;genome-wide;genomic locus;Genomic Segment;Health;High-Throughput Nucleotide Sequencing;Hip Osteoarthritis;human old age (65+);Immunologics;improved;Individual;Inflammation Mediators;Inflammatory;innovation;insight;joint function;Joints;Knee Osteoarthritis;Libraries;Location;Machine Learning;machine learning model;Methods;Methylation;methylation pattern;Mission;model development;Modeling;Modification;Morbidity - disease rate;mortality;Musculoskeletal Diseases;next generation;next generation sequencing;novel;Pain;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pattern;Performance;peripheral blood;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;Physicians;Pilot Projects;Prognosis;protein biomarkers;Public Health;radiological imaging;Research;Research Personnel;Sampling;Serum;sodium bisulfite;subchondral bone;success;System;systemic inflammatory response;targeted sequencing;Techniques;Testing;Time;timeline;Tissues;Translating;Translations;United States National Institutes of Health;Urine;Validation;Work

PROJECT_TITLE: Peripheral blood mononuclear cell epigenetic associations in and biomarkers for knee osteoarthritis development and progression

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: DAVIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative This project provides a new theory that supports a novel mechanistic role for the low abundance membrane localized phospholipid PI(4,5)P2 as a stabilizer of cardiac Cav1.2 channel expression on the sarcolemma. The potent vasopressor Angiotensin II (AngII) is released acutely in the course of normal BP control, and chronically during heart failure as a physiological strategy to increase cardiac output. We propose a mechanism, whereby Gαq-coupled receptor mediated PI(4,5)P2 hydrolysis during this physiological signaling pathway, triggers cardiac CaV1.2 channel internalization, providing a means to acutely tune cellular excitability and modulate EC-coupling in health, but triggering loss of couplons, pathological cardiac remodeling and hypertrophy during chronic stimulation.

PI_NAMEs: DIXON, ROSE ELLEN (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: actin capping protein;Actins;Acute;Address;Adult;Angiotensin II;Arachidonic Acids;Architecture;Area;Biochemistry;Biological Assay;Biomechanics;Biotinylation;blood pressure control;blood pressure regulation;Bypass;Calcium;calmodulin-dependent protein kinase II;Cardiac;Cardiac Myocytes;Cardiac Output;cardioprotection;Cell Death;Cell membrane;Cell surface;Cells;Chronic;Consensus;Coupled;Coupling;Cyclic AMP-Dependent Protein Kinases;Cytoskeleton;Data;Dimerization;Electrophysiology (science);Electrostatics;Endocytosis;Equilibrium;Excision;experimental study;F-Actin;Functional disorder;Gene Expression;Goals;Health;Heart failure;heart function;Hydrolysis;Hypertension;Hypertrophy;Image;imaging approach;improved;in silico;Infusion procedures;innovation;Ion Channel;Knowledge;latrunculin A;Ligation;Link;Lipids;Mass Spectrum Analysis;Mediating;Membrane;Microtubules;Modeling;Mus;Muscle Cells;Myocardial;nano;Nocodazole;novel;nuclear factors of activated T-cells;Optics;Output;patch clamp;Pathologic;Perfusion;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phospholipase C;Phospholipids;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;Play;prevent;Production;Protein Dephosphorylation;Proteins;PTEN gene;receptor;recruit;Regulation;response;Role;RyR2;Sarcolemma;Signal Pathway;Signal Transduction;Sirolimus;Stress;Structure;superresolution imaging;Surface;System;Techniques;Testing;theories;tool;trafficking;Vasoconstrictor Agents;Ventricular;Visualization

PROJECT_TITLE: Lipid regulation of Cardiac Excitation-Contraction coupling

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Narrative Overall The City of Hope Comprehensive Cancer Center leverages the scientific expertise of 175 cancer-focused investigators who form five productive Research Programs spanning basic, translational, clinical, and population- based research that are supported by unique institutional resources and a robust cancer-focused research funding base. An active clinical trials portfolio builds on institutional research discoveries to facilitate advances across the translational research continuum that benefit the population of a diverse Catchment Area and the larger community of people at risk for or affected by cancer.

PI_NAMEs: CARPTEN, JOHN D. (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Acceleration;Achievement;Address;Affect;Aging;anti-cancer research;B lymphoid malignancy;base;Basic Science;Biological;California;Cancer Burden;Cancer Center Support Grant;Cancer Patient;cancer prevention;Caring;Catchment Area;cell growth;Cell Therapy;chimeric antibody;City of Hope Comprehensive Cancer Center;Clinical;clinical practice;Clinical Research;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Conduct Clinical Trials;County;Development;Diagnosis;Early Diagnosis;Education;Enrollment;equity, diversity, and inclusion;experience;first-in-human;Fostering;frontier;Funding;gene function;Grant;Growth;health equity promotion;improved;Individual;Informatics;Infrastructure;Institution;Intervention;Intervention Trial;Investigation;Leadership;Licensing;life span;Los Angeles;Malignant Neoplasms;manufacturing facility;member;Mission;next generation;novel;novel therapeutic intervention;Oranges;outreach;participant enrollment;Pathway interactions;Patient Care;Patients;Peer Review;Persons;Policies;Population;population based;Population Heterogeneity;Population Research;Population Study;Populations at Risk;precision medicine;Prevention;Prevention approach;Productivity;programs;Publications;Publishing;Research;research clinical testing;Research Personnel;Research Support;Resolution;Resource Sharing;Resources;Risk;Rural;Science;Scientist;skills;Speed;Strategic Planning;success;survivorship;Teacher Professional Development;Training;Training and Education;Translational Research;Translations;treatment trial;Urban Population;Vision

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: BAKER-LEE, ASHLEY ELIZABETH (contact)

PROJECT_TERMS: Address;Adherence;Administrative Efficiency;Businesses;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Patient;career;Caring;Catchment Area;City of Hope Comprehensive Cancer Center;Clinical;Clinical Research;Communication;Communities;Comprehensive Cancer Center;Critiques;Development;Education;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;expectation;experience;Faculty Recruitment;Fostering;Funding;Guidelines;Information Systems;Information Technology;Infrastructure;innovation;Laboratory Research;Leadership;meetings;member;Mission;multidisciplinary;NCI Center for Cancer Research;Occupational activity of managing finances;Outcome;Pilot Projects;Play;population based;Population Research;Process;programs;recruit;Reporting;Research;Research Activity;Research Infrastructure;Research Personnel;Research Support;Resource Sharing;Resources;Role;Science;Services;skills;square foot;Strategic Planning;Training Activity;Training and Education;Translational Research

PROJECT_TITLE: Cancer Center Administration


PI_NAMEs: MORTIMER, JOANNE E. (contact)

PROJECT_TERMS: Academy;Acceleration;Aging;anti-cancer research;Award;Cancer Center Support Grant;cancer education;Cancer Education Grant Program;cancer therapy;career;career development;Child;Cities;City of Hope Comprehensive Cancer Center;Climate;Clinical;Clinical Investigator;Clinical Oncology;Clinical Research;Clinical Trials;Communities;Competence;Comprehensive Cancer Center;Dedications;Diverse Workforce;DNA Damage;Doctor of Philosophy;Education;education resources;Educational Curriculum;Educational workshop;efficacy evaluation;elementary school;Ensure;Environment;Evaluation;experience;Experimental Designs;Face;Faculty;Fostering;Funding;Future;Goals;Health;high school;Individual;Informatics;Infrastructure;Institution;International;Investments;K-Series Research Career Programs;Leadership;Malignant Neoplasms;Medical;meetings;member;Mentorship;Mission;Modern Medicine;multidisciplinary;next generation;Oncogenic;Outcome Assessment;Peer Review;Persons;Physicians;Population Heterogeneity;post-doctoral training;Postdoctoral Fellow;Prevention;profession allied to medicine;Program Evaluation;programs;Recording of previous events;recruit;Reporting;Research;research and development;Research Personnel;Resources;response;responsible research conduct;Scholars Program;Science;Signal Transduction;skills;statistics;stem cell biology;student training;Students;success;Training;Training and Education;training opportunity;Training Programs;Training Support;Translational Research;translational scientist;Travel;tumor metabolism;undergraduate student;Underrepresented Populations;Underserved Population;Woman;Workforce Development

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: GALVESTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE Cocaine use disorder (CUD) is a public health emergency with no FDA-approved medication and damage inflicted well beyond the affected individual to the families, communities, and society. This project employs a multidisciplinary approach to discover novel small molecules with unique modes of enhancing serotonergic function to support extended recovery from CUD.

PI_NAMEs: CUNNINGHAM, KATHRYN A.;ZHOU, JIA  (contact)

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: Address;Affect;Agonist;Allosteric Site;antagonist;Behavioral;Behavioral Model;behavioral phenotyping;Binding;Biological Assay;Brain Diseases;Categories;Cellular Assay;Chemicals;clinical diagnosis;Cocaine;cocaine exposure;cocaine seeking;Cocaine use disorder;Cognitive;Communities;craving;Cues;Development;Dimensions;Docking;drug discovery;Drug Kinetics;drug metabolism;Drug Targeting;Drug usage;efficacy evaluation;Elements;Family;FDA approved;Funding;Generations;Goals;improved;in silico;In Vitro;in vivo;in vivo evaluation;Individual;innovation;interdisciplinary approach;Knowledge;Lifestyle-related condition;Ligands;Lighting;Link;male;Medical;member;Modeling;molecular modeling;negative affect;neuropsychiatric disorder;next generation;novel;novel therapeutic intervention;Outcome;Patients;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology;positive allosteric modulator;Pre-Clinical Model;programs;Property;psychologic;Public Health;public health emergency;rational design;Rattus;receptor;receptor function;Recovery;Relapse;Risk;Rodent;Science;Serotonin;Serotonin Receptor 5-HT2C;Signal Transduction;Site;small molecule;social;Societies;Specificity;Stress;System;Therapeutic;Treatment Efficacy;Withdrawal

PROJECT_TITLE: 5-HT2 Receptor Allosterism in Cocaine Use Disorder

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS-R]


PI_NAMEs: KITTLES, RICK A. (contact)

PROJECT_TERMS: Accountability;Adoption;African American;Area;Awareness;Basic Science;Behavior;Cancer Center Support Grant;Catchment Area;Cities;City of Hope Comprehensive Cancer Center;Climate;Clinical;Clinical Sciences;Collaborations;Communication;Communities;community engagement;Community Outreach;Compensation;Comprehensive Cancer Center;Creativeness;Data;design;Development;diversity and inclusion;DNA;Doctor of Philosophy;E-learning;economic disparity;Educational Grants;Educational process of instructing;Employee;empowerment;Ensure;Environment;Equity;equity, diversity, and inclusion;Event;experience;Eye;Faculty;falls;Fellowship;Fostering;functional group;Funding;Future;graduate school;graduate student;Health;Health Disparities Research;health equity;Historically Black Colleges and Universities;Holidays;holistic approach;improved;Incidence;Individual;Infrastructure;innovation;insight;Institution;instructor;Internships;Laboratories;Latino;Lead;Leadership;leadership development;Learning;lens;Malignant neoplasm of prostate;Malignant Neoplasms;Measurable;Measures;Minority;Minority-Serving Institution;Mission;Nurses;operation;Outcome;Participant;Pathway interactions;Patient Care;Patients;Performance;Population;Population Sciences;Postdoctoral Fellow;precision medicine;Process;Program Development;Program Sustainability;programs;recruit;Research;research faculty;Role;Scholarship;Services;social disparities;Strategic Planning;Stretching;Students;Suggestion;Surgeon;Surveys;Training;Translational Research;trend;unconscious bias;Underrepresented Populations;Universities;Update;Vision;Woman;Work

PROJECT_TITLE: Plan to Enhance Diversity


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PHR: PROJECT NARRATIVE Current therapies for mitochondrial long-chain fatty acid oxidation disorders (LC-FAODs) are only partially effective in heart and not effective in muscle. The proposed research seeks to leverage a new mechanism to boost the function of peroxisomes, which can also break down fatty acids, to treat LC-FAOD symptoms in liver, heart, and muscle.

PI_NAMEs: GOETZMAN, ERIC S (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Ablation;Acetates;Acetylation;acyl-CoA oxidase;Acylation;Affect;Aging;Automobile Driving;Carbon;Catabolism;Citric Acid Cycle;Coenzyme A;Cultured Cells;Data;Diabetes Mellitus;Dicarboxylic Acids;Disease;Energy-Generating Resources;Enoyl-CoA Hydratase;Enzyme Stability;Enzymes;Exposure to;Fasting;fatty acid oxidation;Fatty Acids;feeding;Functional disorder;functional improvement;gain of function;Grant;Hand Strength;Heart;heart function;Human;Impairment;improved;Individual;Injury to Kidney;Knowledge;lipid metabolism;Lipids;Literature;Liver;liver function;long chain fatty acid;Lysine;Malignant Neoplasms;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;mouse model;Mus;Muscle;Muscle function;Nature;Organ;Organism;Oxidative Stress;Oxidoreductase;Pathology;Pathway interactions;Patients;Peripheral;peroxisome;pharmacologic;Post-Translational Protein Processing;Production;Proteins;Recombinant Proteins;Regulation;Research;response;Sirtuins;Site;Stress;Structure;Succinates;succinyl-coenzyme A;Symptoms;Testing;Therapeutic;Therapeutic Effect;Tissues

PROJECT_TITLE: Regulation of Peroxisomal Metabolism by Lysine Acylation

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: ASHING, KIMLIN TAM (contact)

PROJECT_TERMS: Address;Advocate;Aging;anti-cancer research;Area;Award;Awareness;Back;Black Populations;Black race;Breast;California;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer Patient;cancer prevention;Caring;Catchment Area;Cervical;Clinical;Clinical Research;Clinical Trials;colon cancer screening;Colon Carcinoma;Colorectal;Communication;Communities;community advisory board;community center;community clinic;community collaboration;community engagement;Community Health;community organizations;Community Outreach;community partners;community partnership;community research;County;Data;data sharing;Diagnosis;digital technology;Disparity;Education;Educational workshop;Elderly;Environment;Equity;ethnic diversity;Faculty;falls;Fostering;Foundations;Funding;Gender Identity;Genomics;Goals;Grant;health determinants;health disparity;health equity;Health Services Accessibility;Immigrant;improved;Institution;International;Intervention;Investments;Lead;life span;Liver;Los Angeles;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;member;Minority;Mission;multi-ethnic;Multiple Myeloma;Needs Assessment;neoplasm registry;Oncology;Oranges;outreach;Pathway interactions;patient response;Policies;Population;Population Heterogeneity;Prevention;programs;Prostate;Reporting;Research;Research Personnel;Resources;response;Rights;Risk;Risk Factors;Science;Scientist;screening;Screening for cancer;Services;sexual identity;smoking cessation;Statutes and Laws;Strategic Planning;Testing;Tobacco;tobacco control;Trainers Training;Training;Training and Education;Training Programs;Work

PROJECT_TITLE: Community Outreach and Engagement


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Pediatric;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Cryptosporidium is one of the most important causes of diarrheal disease in the U.S. and around the world. This project will unravel the mechanisms of parasite lifecycle progression and sexual replication.

PI_NAMEs: STRIEPEN, BORIS  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Ablation;Acquired Immunodeficiency Syndrome;Apical;asexual;Atlases;Biological Assay;Cell Cycle Regulation;Cells;Child;Child Health;Childhood;chlorination;Chromosome Mapping;Cryo-electron tomography;Cryptosporidiosis;Cryptosporidium;Cytoskeleton;Dedications;Development;Diarrhea;diarrheal disease;Disease;Disease Outbreaks;Docking;effective therapy;electron tomography;Elements;Epigenetic Process;Event;Female;Fertilization;Flagella;Future;gain of function;Gametogenesis;Gene Expression;Genes;Genetic;Genetic study;Genetic Transcription;Genome;Germ Cells;histone modification;HIV/AIDS;Immunocompetent;Immunosuppression;imprint;Individual;Infant Mortality;Infection;insight;interest;intestinal epithelium;Intestines;Life Cycle Stages;Link;live cell imaging;loss of function;male;Malignant Neoplasms;Malnutrition;Maps;Measures;Methods;Modeling;Molecular;mortality;mutant;next generation;Nutritional status;Opportunistic Infections;Organ Transplantation;overexpression;Parasites;pathogen;Patients;Pharmaceutical Preparations;Phase;Predisposition;Prevention;Process;Program Development;programs;Prophylactic treatment;Proteins;Public Health;Reproduction spores;Resistance;Resolution;Risk Factors;Role;Rotavirus;sex;Sexual Development;single cell sequencing;Specificity;Sporozoites;Structure;Subcellular structure;System;Technology;Testing;transcription factor;transmission process;Vaccines;Water;waterborne illness

PROJECT_TITLE: Sexual Development of Cryptosporidium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-L(02)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: ITHACA

ORG_DEPT: ADMINISTRATION

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE The Comparative Medicine Program at Cornell University is preparing accomplished and highly motivated veterinarians for discovery-based and public health careers in basic and translational science. By virtue of their broad knowledge of comparative disease and strong intellectual and lateral thinking abilities, veterinarians with advanced scientific training are expected to play an essential role in biomedical science and public health and to promote the NIH goal of developing, maintaining, and renewing scientific human resources that will ensure the Nation's capability to prevent disease.

PI_NAMEs: PARKER, JOHN S (contact);WEISS, ROBERT S

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: comparative;Medicine;Training Programs

PROJECT_TITLE: Graduate Training Program in Comparative Medicine


NIH_SPENDING_CATS: Rehabilitation

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative This grant supports training of exceptional rehabilitation scientists through a highly integrated, interdisciplinary Movement Science PhD and postdoctoral training program. Our graduates are experts in the study of movement, with work spanning from the basic science level through to clinical application. Individuals trained in the Movement Science Program go on to hold research positions, in academia or industry, and contribute to the science of rehabilitation, its translation to clinical practice and the training of future leaders in the field.

PI_NAMEs: LANG, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Kinesiology;Training Programs

PROJECT_TITLE: Doctoral Training Program in Movement Science


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: KWAK, LARRY W (contact)

PROJECT_TERMS: Address;anti-cancer research;Applications Grants;Area;Award;Basic Science;Biomedical Research;Budgets;Cancer Center;Cancer Center Support Grant;cancer prevention;career;career development;Categories;cell growth;Cell Therapy;Cities;City of Hope Comprehensive Cancer Center;Clinical;Clinical Investigator Award;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;community engagement;Community Outreach;Comprehensive Cancer Center;Data;Data Collection;design;Development;Disabled Persons;disadvantaged background;Disparity in diagnosis;Eligibility Determination;Ensure;ethnic minority;experimental study;Faculty;flexibility;Fostering;Funding;Goals;Grant;Guidelines;health disparity;health equity promotion;high reward;high risk;improved;Individual;innovation;Institution;Interdisciplinary Study;Investments;Leadership;Lesbian Gay Bisexual Transgender Queer;meetings;member;Mentors;Mission;Monitor;multidisciplinary;participant enrollment;Patients;Peer Review;Physicians;Pilot Projects;Population;Population Sciences;Precision Medicine Initiative;Production;professor;Program Research Project Grants;programs;Publications;Qualifying;racial minority;Research;Research Activity;Research Personnel;Research Project Grants;Research Proposals;Resource Sharing;Review Committee;Running;Science;Scientist;Services;Site;socioeconomic disadvantage;Testing;Time;Training and Education;Translational Research;Travel;treatment disparity;Underrepresented Populations;United States National Institutes of Health;Veterans;Voting;Wages;Woman;Writing

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Lung;Nutrition;Obesity

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Narrative More than 40% of adults with asthma are obese which leads to increased asthma severity, symptom burden, healthcare utilization and reduced effectiveness of available therapies. This proposal builds on a preclinical and clinical program that indicates glucagon-like peptide-1 receptor agonists (GLP-1RA), FDA approved for the treatment of type II diabetes and obesity, will be efficacious in treating asthma. To validate the therapeutic potential of GLP-1RA in obese and non-obese asthmatics and to address the multimorbidity and polypharmacy plaguing the adult asthma population, we propose to conduct a randomized controlled clinical trial to test the hypothesis that GLP-1RA treatment improves asthma control and reduce airway inflammation.

PI_NAMEs: BERNARD, GORDON RAPHAEL;CAHILL, KATHERINE N (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Abdomen;Address;Adipose tissue;Adolescent;Adult;Adult asthma;adult obesity;Adverse event;Agonist;airway epithelium;airway inflammation;airway remodeling;Allergens;Anti-Inflammatory Agents;Asthma;asthma exacerbation;asthmatic;asthmatic patient;bariatric surgery;Biological Markers;biomarker performance;Biopsy;Body mass index;Body System;Body Weight decreased;Clinical;Clinical Data;cohort;Collection;comorbidity;conventional therapy;Data;design;Development;differential expression;Disease;Double-Blind Method;Effectiveness;efficacy evaluation;eosinophil;Exhalation;FDA approved;Formulation;GLP-I receptor;glucagon-like peptide 1;Glucocorticoids;Goals;granulocyte;health care service utilization;heart function;Homeostasis;Hormones;improved;Inflammasome;Inflammation;Inhalation;insight;Insulin Resistance;insulin sensitivity;Interleukin-13;Interleukin-5;Interleukins;Link;Lung;Lymphoid Cell;Measures;Mediating;Mediator;Metabolic Pathway;methacholine;Modeling;Mucous body substance;multiple chronic conditions;Mus;Nasal Epithelium;neuroprotection;neutrophil;Nitric Oxide;Non obese;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obese Mice;obese person;Obesity;obesity-associated asthma;Oral;Outcome;Pathway Analysis;Pathway interactions;Peptides;periostin;Phase III Clinical Trials;Phenotype;Polypharmacy;Population;pre-clinical;Prediabetes syndrome;predicting response;primary outcome;programs;pulmonary function;Quality of life;Questionnaires;Randomized Controlled Clinical Trials;randomized placebo controlled trial;Respiratory System;Role;Safety;Sampling;secondary outcome;Serum;Severities;small molecule;Specific qualifier value;Sputum;subcutaneous;Subgroup;Symptom Burden;Symptoms;System;Testing;Therapeutic;Therapeutic Intervention;Thinness;Tissues;tool;transcriptome sequencing;Translating;TSLP gene;Viral

PROJECT_TITLE: Glucagon-Like Peptide-1 Receptor Agonist Treatment in Adult, Obesity-Related, Symptomatic Asthma


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative Thyroid cancer patients who are refractory to radioactive iodine treatment have the poorest survival outcomes amongst all thyroid cancer patients. In this context, drug treatments that restore or enhance iodine uptake could significantly improve the treatment of these tumors. This project will develop an assay to study how targeted drugs enhance the ability of tumor cells to concentrate radioactive iodine, which could eventually be translated toward individualizing treatment according to specific patient characteristics.

PI_NAMEs: PRATX, GUILLEM  (contact)

PROGRAM_OFFICER_NAME: SORG, BRIAN S

PROJECT_TERMS: Aftercare;Automation;Biological Assay;Biological Markers;Biopsy;cancer cell;Cancer cell line;Cancer Patient;Characteristics;Clinical;Clinical Management;Clinical Research;detection limit;Development;Differentiation Inducer;Differentiation Therapy;Disease;disease heterogeneity;Distant Metastasis;Dose;Drug Targeting;effective therapy;Effectiveness;Eligibility Determination;Enrollment;Future;Genetic;Goals;Growth;high throughput screening;Image;Imaging Techniques;improved;In Vitro;in vivo;individualized medicine;Iodine;kinase inhibitor;Libraries;Malignant - descriptor;Malignant neoplasm of prostate;Malignant neoplasm of thyroid;Malignant Neoplasms;Measures;Metastatic Prostate Cancer;Modeling;Molecular;Molecular Analysis;Mutation;Neoplasm Metastasis;neoplastic cell;neuroendocrine cancer;Neuroendocrine Tumors;novel;nuclear imaging;Operative Surgical Procedures;Organoids;Outcome;Papillary thyroid carcinoma;patient screening;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Phosphotransferases;Pilot Projects;predictive marker;Primary Neoplasm;Process;Prognosis;Radiation;Radioactive Iodine;radioiodine therapy;Radioisotopes;Radionuclide Imaging;Radiopharmaceuticals;Rapid screening;Recommendation;Refractory;refractory cancer;Refractory Disease;Reproducibility;Resected;Resolution;Sampling;Scanning;Schedule;screening;side effect;Specimen;standard of care;survival outcome;Technology;Testing;Therapeutic;Therapeutic Agents;three dimensional cell culture;thyroid neoplasm;Toxic effect;Translating;Treatment Protocols;tumor;Tumor Tissue;Unresectable;uptake

PROJECT_TITLE: A Novel Assay to Individualize Resensitization of Iodine-Refractory Thyroid Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: TERMINI, JOHN S (contact)

PROJECT_TERMS: Admixture;Advisory Committees;assay development;Biological Products;Biometry;Breast;Cancer Center;Cancer Center Support Grant;cancer initiation;cancer research center director;Cells;City of Hope Comprehensive Cancer Center;Clinical;Clinical Treatment;Collaborations;Complement;Comprehensive Cancer Center;Core Facility;Data;data management;digital imaging;DNA sequencing;Doctor of Philosophy;drug discovery;Ecosystem;Equipment;equipment acquisition;Evaluation;experience;Faculty;Feedback;Future;Genetic;Genomics;Goals;Grant;Health Disparities Research;high throughput screening;humanized mouse;Image;Image Cytometry;imaging facilities;imaging platform;improved;Infrastructure;insight;instrument;interdisciplinary collaboration;Leadership;light microscopy;Maintenance;Malignant Neoplasms;manufacture;Maps;mass spectrometry shared resource;Mass Spectrum Analysis;Mathematics;member;microbiome;microscopic imaging;Mission;Modeling;Monitor;mouse model;nano-string;NCI Center for Cancer Research;novel;Oncology;operation;Pathology;Pathway interactions;Phase;phase 1 study;Play;Policies;Population;pre-clinical;Precision Medicine Initiative;Production;programs;Publications;recruit;Research;Research Activity;Resource Sharing;Resources;Review Committee;Robotics;Role;screening;Services;small molecule;small molecule libraries;Standardization;structural biology;Structure;Surveys;Technology;The Jackson Laboratory;Therapeutic;Tissue imaging;translational pipeline;United States National Institutes of Health;vector

PROJECT_TITLE: Shared Resource Management


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative: This proposal aims to develop the classic Cope rearrangement into a versatile reaction for preparing complex, bioactive molecules of interest to drug discovery. As described herein, our current and future directions will involve continuing to improve our understanding of this transformation, develop unique, complexity-generating transformations and/or sequences where this Cope rearrangement plays a key role, introduce a variety of catalytic-asymmetric methods for accessing enantioenriched building blocks, and prepare molecules of modern interest to drug discovery; a well-rounded and diverse research program focusing both on fundamental and applied chemical discoveries. ! 1!

PI_NAMEs: GRENNING, ALEXANDER JAMES (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: New opportunities for the Cope rearrangement: methods, modular synthesis, and applications in drug discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Mental Health;Mental Illness;Pediatric;Prevention

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE This project will extend existing and develop new models that use whole-genome data measured in parents and offspring to help disentangle the genetic and environmental causes of parent-offspring similarity on traits. We will deploy these new and existing models on three large, publicly available datasets to (a) elucidate which parental traits influence anxiety, depressive, and attentional symptoms in offspring; and (b) better understand how parental psychiatric illness influences their offspring’s social, physical, and mental well-being.

PI_NAMEs: KELLER, MATTHEW CHARLES (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Accounting;Adoption;Age;Alcohol consumption;Anxiety;Attention;Attentional deficit;Behavior;biobank;Child;Cognition;cohort;Complex;Data;Data Set;Data Sources;depressive symptoms;design;Development;Environment;Equation;ethnic diversity;Explosion;Family;Fertilization;Functional disorder;Genes;Genetic;Health;Human Resources;improved;insight;large datasets;Literature;Measures;Mediation;Mental Depression;Mental disorders;Mental Health;Modeling;Nature;novel;offspring;parental influence;parental role;Parents;Partner in relationship;Personal Satisfaction;Phenotype;Play;pleiotropism;Psychopathology;Reproducibility;Research Personnel;Rest;Risk;Role;Sampling;sex;Shapes;Siblings;Smoking;social;Spouses;Symptoms;Techniques;Testing;Time;tool;trait;Twin Multiple Birth;Underrepresented Populations;Variant;Vertical Transmission;Well in self;whole genome

PROJECT_TITLE: Causes and consequences of mental disorders: The environmental and genetic influences of parents on offspring.

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]