ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: NARRATIVE While AIDS-associated cancers are a major cause of death around the globe, those in low- and middle-income countries (LMICs), particularly in sub-Saharan Africa, are much more likely to die from cancer due to shortages of trained cancer researchers, oncologists, and support staff and a lack of healthcare infrastructure and expertise for diagnosing and treating cancers. The AIDS Malignancies Training and Research International Program (AMTRIP) seeks to address these challenges by training a cadre of Zambian basic biomedical researchers and practitioners from the Cancer Diseases Hospital (the main LMIC institution) and partnering organizations in the skills necessary to further the country's research agenda in cancer biology and genomics, which will translate to better clinical care for cancer patients. Upon completion of master's and doctoral training, program fellows will be provided employment in Zambian medical institutions in order to begin addressing these challenges in-country.

PI_NAMEs: KANKASA, CHIPEPO ;WOOD, CHARLES  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adult;AIDS related cancer;anti-cancer research;antiretroviral therapy;Behavioral;Bioinformatics;Cancer Biology;Cancer Research Infrastructure;Chronic;Clinical;Collaborations;Country;design;Diagnosis;Disease;Doctor of Philosophy;doctoral student;Educational workshop;Epidemic;experience;extend lifespan;Future;Genomics;Graduate Degree;Health Personnel;Health Professional;HIV-1;HIV/AIDS;hospital laboratories;Hospitals;Human Resources;Immunosuppression;Individual;Infrastructure;Institution;Instruction;International;Laboratories;laboratory facility;Lead;Leadership;Malignant Neoplasms;medical schools;Mentorship;Molecular;molecular pathology;Nebraska;next generation;Outcome;Persons;Population;prevent;programs;recruit;Research;Research Methodology;Research Personnel;Role;success;Teaching Hospitals;Techniques;Training;Universities;Zambia


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ALBUQUERQUE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PI_NAMEs: LOKER, ERIC SAMUEL (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Affect;Africa;Africa South of the Sahara;African;Alleles;Area;Asexual Reproduction;Biomphalaria;Castration;Cattle;Characteristics;chemotherapy;Climate;climate change;Collaborations;Coupled;CRISPR/Cas technology;Development;experimental study;Exposure to;Fibrinogen;field study;Fresh Water;Funding;General Practitioners;Genes;Goals;Histologic;Human;Immune;immune resistance;Immune response;In Vitro;in vivo;Individual;Infection;infection rate;innovation;Instruction;Interruption;Intestines;Kenya;Larva;Learning;Life Cycle Stages;Mediating;Medical;Medical Research;metabolomics;Methods;mindfulness;Modeling;Monitor;neglected tropical diseases;novel;Outcome;Parasites;performance site;Persons;Phenotype;Play;Population;Predisposition;prevent;Production;Progress Reports;Proteins;Proteomics;Reproduction;Research Institute;resilience;Resistance;resistance mechanism;response;RNA Interference;Role;Schistosoma;Schistosoma mansoni;Schistosome Parasite;Schistosomiasis;Scientist;Snails;Sporocysts;Stream;success;Techniques;Temperature;Testing;Training;transcriptome sequencing;transcriptomics;transmission process;vector;vector competence;Water;Work

PROJECT_TITLE: Snail-Related Studies of Transmission & Control of Schistosomiasis in Kenya

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: SHARMA, ASHISH ARUNKUMAR (contact)

PROJECT_TERMS: Address;Adolescence;Adult;age group;age related changes;Anti-Inflammatory Agents;antiretroviral therapy;Bile Acids;Binding;biobank;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Maintenance;Cell Physiology;Cells;Child;Childhood;clinical trial protocol;cohort;Complex;cytokine;Data;DNA;early childhood;effector T cell;efficacy evaluation;Emigrant;Environment;Epigenetic Process;epigenetic profiling;exhaustion;Flow Cytometry;Frequencies;Genes;Genetic Transcription;high dimensionality;HIV;HIV Infections;Homeostasis;Immune;immune function;Immune response;Immune system;Immune System Diseases;Immunity;Immunologics;Immunology;immunoregulation;Impairment;integration site;interdisciplinary approach;interest;Interleukin-10;International Maternal Pediatric Adolescent AIDS Clinical Trials;Interruption;Knowledge;Life;Longitudinal cohort;machine learning algorithm;Maintenance;Memory;Metabolic;metabolomics;microbial;Mission;Modeling;Molecular;Monitor;Nature;Neonatal;novel;Output;pathogen;Pathway interactions;pediatric human immunodeficiency virus;perinatal HIV;perinatal period;pressure;Production;programs;Proviruses;Regulatory T-Lymphocyte;Research;Research Personnel;Sampling;SIV;stemness;synergism;System;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Thymus Gland;Transforming Growth Factor beta;Translations;Viremia;Volatile Fatty Acids


ADMINISTERING_IC: CK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Our proposed research addresses problems of high importance to public health. Healthcare-associated infection, antibiotic resistance, and emerging pathogens have profound impacts on morbidity and mortality. The research proposed here will lead to better ways to control and respond to these threats to human health.

PI_NAMEs: RUBIN, MICHAEL A.;SAMORE, MATTHEW H (contact)

PROJECT_TITLE: Intermountain Program on Antibiotic Resistance and microbial Threats (IMPART)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Patient Safety

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Not applicable

PI_NAMEs: FURQAN, MUHAMMAD  (contact)

PROJECT_TERMS: Adherence;adverse event monitoring;anti-cancer research;Biometry;Cancer Center Support Grant;career;Clinical;Clinical Cancer Center;Clinical Data;Clinical Investigator;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Communication;Comprehensive Cancer Center;Consent;Data;Data Collection;data management;Dedications;Development;Disease;Education;Eligibility Determination;Ensure;Evaluation;Feedback;Funding;improved;Industry;Informed Consent;Infrastructure;innovation;Institution;Institutional Review Boards;Intervention;investigator-initiated trial;Medical;Mentorship;Mission;Modification;Molecular Epidemiology;Monitor;Monitoring Clinical Trials;multidisciplinary;National Clinical Trials Network;Oncology Group;Participant;participant enrollment;participant safety;Phase;protocol development;Protocols documentation;quality assurance;quantitative imaging;Radiology Specialty;Reporting;Research Personnel;Resources;response;Review Committee;Route;Safety;safety study;Schedule;screening;Services;System;Toxic effect;translational cancer research;Work

PROJECT_TITLE: Clinical Protocol and Data Management

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: NS

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Microbiome;Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Glioblastoma (GBM) is the most common and deadly malignant brain tumor in adults and thus far has been resistant to immunotherapeutic strategies due to its immunosuppressive tumor microenvironment. The gut and tumor microbiome are known immune modulators and gut microbial composition as been demonstrated to significantly impact patient responses to immunotherapy in multiple solid malignances. This project will examine the impact of the microbiome (gut and tumor) on the immune composition of the GBM microenvironment and patient outcome.

PI_NAMEs: FERGUSON, SHERISE DESIREE (contact);WARGO, JENNIFER A.

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Adult;anti-tumor immune response;Architecture;bioinformatics pipeline;Blood;Brain Neoplasms;cancer care;Cancer Center;cancer type;candidate identification;Cells;Central Nervous System;Chemotherapy and/or radiation;Clinical;clinical outcome measures;Data;Data Set;Dedications;Development;Disease;Evaluation;Excision;fecal transplantation;Feces;genome sequencing;Glioblastoma;Glioma;Goals;gut microbes;gut microbiome;gut microbiota;gut-brain axis;Immune;immune checkpoint blockade;Immune Evasion;Immune response;Immunocompetent;Immunomodulators;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;insight;Intervention;Knowledge;Long-Term Survivors;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;microbial;microbial composition;microbial signature;microbiome;microbiome signature;microbiota;Microglia;Modeling;mouse model;Mus;neuroinflammation;Neurologic;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Outcome Measure;Pathogenesis;Pathway interactions;patient response;Patient-Focused Outcomes;Patients;pre-clinical;Property;prospective;Recurrent tumor;Reporting;Resistance;response;Role;sample collection;Sampling;Signal Transduction;Solid;success;Survivors;The Cancer Genome Atlas;therapy resistant;transcriptome sequencing;transplant model;Treatment outcome;treatment response;tumor;tumor growth;tumor microbiome;tumor microenvironment;tumor-immune system interactions;Viral;virome;whole genome;Work

PROJECT_TITLE: Elucidating the Role of the Gut and Tumor Microbiome in Malignant Glioma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: GOODHEART, MICHAEL J (contact)

PROJECT_TERMS: Address;anti-cancer research;Cancer Center Support Grant;cancer clinical trial;Cancer Intervention;Clinical Cancer Center;Clinical Oncology;Clinical Trials;Comprehensive Cancer Center;Development;Disease;Ensure;Evaluation;Goals;Holden Comprehensive Cancer Center at the University of Iowa;improved;Institution;Institutional Review Boards;Monitor;multidisciplinary;NCI-Designated Cancer Center;Oncology Group;patient population;Peer Review;Process;Protocols documentation;Research;Resources;Review Committee;Science;System

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: ANN ARBOR

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project narrative Transcription is dysregulated in every human disease as either a cause or an effect and as such represents a potentially powerful intervention point for therapeutics; a significant impediment to progress are the many questions regarding the complex network of protein-protein interactions that regulates this process. In this research plan we implement a combination of chemical biology tools and approaches to define key binding interactions and conformational changes that produce function in vitro and in cells. In doing so, we will discover new opportunities for drug discovery, with a particular focus on transcriptional pathways integral to metabolic disease and cancer.

PI_NAMEs: MAPP, ANNA K. (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Address;Binding;Biology;Cells;Chemicals;Complex;drug discovery;Epigenetic Process;Funding;Genetic Transcription;human disease;In Vitro;Intervention;Label;Malignant Neoplasms;Metabolic Diseases;Modeling;Molecular;Molecular Conformation;molecular modeling;molecular recognition;Pathway interactions;Polymerase;Process;Protein Dynamics;protein protein interaction;Research;Role;Therapeutic;tool;Transcription Coactivator;Transcription Process;Transcriptional Activation

PROJECT_TITLE: Probing transcriptional activation at the molecular level

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE More than 40% of children under 5 years in low- and middle-income countries are at risk of not reaching their developmental potential. An important strategy is to promote the capabilities of caregivers and communities to provide nurturing, supportive care to children at risk. In this study, we will evaluate the use of an individualized intervention to caregivers by community health workers—the international Guide for Monitoring Child Development— to promote developmental outcomes. We will also evaluate the barriers, facilitators, and cost-effectiveness of the intervention.

PI_NAMEs: ROHLOFF, PETER  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: 2 year old;Address;Adoption;Affect;Age;aged;arm;Caregiver support;Caregivers;Caring;Characteristics;Child;Child Development;Cluster randomized trial;Collaborations;Communication;Communities;Community Health Aides;community intervention;community led intervention;Consolidated Framework for Implementation Research;contextual factors;cost;Cost Analysis;cost effective intervention;cost effectiveness;Cost Effectiveness Analysis;Data;Development;Dropout;Early identification;economic evaluation;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;effectiveness/implementation hybrid;effectiveness/implementation trial;empowerment;Environment;Evaluation;Family;Focus Groups;Funding;Goals;Guatemala;Health;Home;Hour;human capital;impaired brain development;implementation barriers;implementation evaluation;implementation facilitators;implementation framework;implementation intervention;implementation process;implementation science;improved;improved outcome;India;Individual;Infant Development;Institution;instrument;International;Intervention;intervention cost;Interview;Learning;low and middle-income countries;Maintenance;Malnutrition;Measurement;Monitor;Outcome;Participant;patient home care;Patient-Focused Outcomes;personalized approach;Phase;Policy Maker;Population;Poverty;Preventive healthcare;programs;Protocols documentation;Provider;Qualitative Evaluations;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Training;Resource Allocation;resource guides;Risk;Risk Factors;Rural;Rural Community;Sensitivity and Specificity;social;success;Supportive care;System;Testing;therapy development;treatment as usual;UNICEF;United States National Institutes of Health;Visit;Work;World Health Organization

PROJECT_TITLE: An Individualized Approach to Promote Nurturing Care in Low and Middle Income Countries: A Hybrid Effectiveness/Implementation Trial of the International Guide for Monitoring Child Development


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Prevention

ORG_CITY: MADISON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: This study examines how environmentally sensitive mechanisms regulate orofacial development and contribute to orofacial clefts of the lip and palate. The results are expected to substantially advance the long- term goal of developing strategies to prevent orofacial clefts.

PI_NAMEs: LIPINSKI, ROBERT  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Address;Advanced Development;Affect;antagonist;Attenuated;Biological;Biological Models;Biology;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cells;Cephalic;Chemicals;Choline;cleft lip and palate;comparison control;Complex;Conceptions;Congenital Abnormality;Connective Tissue;craniofacial;Data;Development;dietary;Dietary intake;DNA Methylation;DNA Methylation Inhibition;Embryo;Environment;Epidemiology;Epigenetic Process;epigenome editing;Etiology;Face;Folic Acid;Foundations;Gene Expression;Genetic;Genetic Models;Genetic study;Genetic Transcription;Genome;genome wide methylation;Goals;Head;Human;in vitro Model;in vivo;Individual;insight;Intervention;Investigation;Knowledge;Link;Lip structure;malformation;Mediating;Mediator;Medical;Methylation;methylome;Modeling;Molecular;Morbidity - disease rate;Morphogenesis;mouse model;Multipotent Stem Cells;Neural Crest;Neural Crest Cell;Newborn Infant;novel;orofacial;orofacial cleft;orofacial development;Outcome;Palate;Pathogenesis;Penetrance;Play;Population;Predisposition;prevent;Prevention;Prevention strategy;Proliferating;Reporting;Research;response;Risk;Risk Reduction;Role;stem cell population;Structural Congenital Anomalies;Structural defect;Testing;Therapeutic;Tissues;trait;transcriptome;transcriptome sequencing;transcriptomics;whole genome

PROJECT_TITLE: DNA methylation in orofacial clefting

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: PROJECT NARRATIVE Conventional fluorescence imaging strategies lack the multiplexing capabilities and spatiotemporal resolution required to visualize and track distinct intracellular components simultaneously at the single-molecule level in live cells. This proposal is aimed at overcoming these stringent limitations with the development of synthetic photoactivatable fluorophores specifically designed to allow the parallel monitoring of multiple targets in the interior of live cells with statistical confidence, spatial resolution at the nanometer level and temporal response in the millisecond domain. The resulting unprecedented imaging schemes can contribute to the elucidation of the fundamental factors governing cellular processes at the molecular level and, hence, can have transformative implications in biomedical research.

PI_NAMEs: RAYMO, FRANCISCO M (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;aqueous;Binding;Biological;Biomedical Research;Calibration;cell injury;Cell membrane;Cell Physiology;Cell Survival;Cells;Cellular Structures;Characteristics;chromophore;Color;Complex;design;Development;Discrimination;Dyes;Dynein ATPase;Electromagnetics;embryonic stem cell;Engineering;Ensure;Environment;Enzymes;Family;Fluorescence;fluorescence imaging;Fluorescent Probes;fluorophore;Glass;Goals;Histone H2B;Homeostasis;Image;Individual;innovation;Investigation;irradiation;Kinesin;Label;Ligands;Lighting;live cell imaging;MAP4;Measurement;Microscopy;millisecond;Modeling;Molecular;molecular dynamics;Molecular Motors;Monitor;Motion;nanoGold;nanometer;optical spectra;Optics;Outcome;particle;Performance;photoactivation;Photobleaching;physical separation;Plasmids;Positioning Attribute;Property;Proteins;Protocols documentation;Research;Resistance;Resolution;response;Scheme;single molecule;Solubility;spatiotemporal;Structure;superresolution imaging;synthetic construct;System;Technology;technology research and development;temporal measurement;Time;tool;Transfection;Tubulin;ultra high resolution;Visible Radiation;Visualization

PROJECT_TITLE: Photoactivatable Fluorophores for High-Throughput Multiplexed Tracking of Single-Molecules in Live Cells

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: PROJECT NARRATIVE Vaccine Hesitancy is complex, influenced by factors at the individual, community, provider, health care system, and societal levels. Despite being a key “super-spreader” population transmitting SARS-Co-V2, the causative agent of COVID-19 (COVID), acceptance of COVID vaccination is lowest among African American and young adult populations. A digital health intervention has the potential to increase the reach and uptake of COVID vaccination among African American young adults which is central to ending the pandemic.

PI_NAMEs: BUDHWANI, HENNA ;HIGHTOW-WEIDMAN, LISA B (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: acceptability and feasibility;Address;African American;Age;American;arm;Attention;Attitude;Behavior;Behavioral;Belief;Charge;Clinical Research;Cognitive;Collaborations;Communication;Communities;community based participatory research;community collaboration;community partners;community partnership;Complex;COVID-19;COVID-19 intervention;COVID-19 morbidity;COVID-19 vaccination;COVID-19 vaccine;Data Collection;Decision Making;design;digital;digital health;Dimensions;Disclosure;Discrimination;distrust;effectiveness outcome;Emotional;empowerment;Ensure;Epidemic;Equity;Ethics;experience;Face;family influence;Focus Groups;Geographic Locations;Health;health care availability;health disparity;Health Insurance;Healthcare Systems;HIV;Hybrids;implementation barriers;implementation evaluation;implementation facilitators;implementation science;implementation/effectiveness;Individual;Inequity;Infection;Infrastructure;Institution;Intervention;Interview;Knowledge;Life;Measures;Medical;Medicine;Methods;Misinformation;Modality;mortality;multidisciplinary;National Institute on Minority Health and Health Disparities;novel;Outcome;pandemic disease;Participant;peer influence;Persons;Phase;Population;prototype;Provider;provider communication;Randomized;Randomized, Controlled Trials;Recording of previous events;Regulation;remote delivery;Research;Research Methodology;resilience;response;Running;Safety;SARS-CoV-2 transmission;Series;Site;social;Social Distance;social stigma;standard of care;Stigmatization;Surveys;tailored messaging;Testing;theories;transmission process;treatment arm;Trust;uptake;Vaccination;vaccine acceptance;vaccine hesitancy;vaccine refusal;Vaccines;young adult

PROJECT_TITLE: A multidimensional Digital Approach to Address Vaccine Hesitancy and Increase COVID-19 Vaccine Uptake among African American Young Adults in the South

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-G(90)S]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Genetics;Human Genome;Liver Disease;Nutrition;Obesity

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative The incidence of obesity and type 2 diabetes continues to rise in the United States. Non-alcoholic fatty liver disease is a significant co-morbidity in the pathogenesis of type 2 diabetes. We believe that methylglyoxal restores metabolic and transcriptional homeostasis in the pathogenesis of these disease states and this project is designed to test this hypothesis.

PI_NAMEs: GALLIGAN, JAMES J (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acetyl-CoA Carboxylase;Address;adenylate kinase;Adipose tissue;Adult;American;Architecture;Area;ATAC-seq;Binding;Biochemistry;Blood;Bypass;carbohydrate metabolism;Catabolism;Chromatin;Circulation;Classification;Clinical;cohort;comorbidity;Consumption;CRISPR/Cas technology;Data;design;Diabetes Mellitus;Diet;dietary;Dietary Sugars;Disease;Disease Progression;Drug Metabolic Detoxication;Energy Metabolism;Enzymes;epidemiology study;epigenomics;Equilibrium;Exhibits;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Fatty Liver;feeding;Fructose;fructose-1-phosphate;Genes;Genetic Transcription;Glucose;glucose tolerance;Glucose-6-Phosphate;Glycolysis;Goals;Health;Hepatic;Hepatocyte;High Fat Diet;Histone H1;histone modification;Histones;Homeostasis;Hyperglycemia;in vivo;Incidence;insulin sensitivity;interdisciplinary approach;Intestines;Ketones;Knockout Mice;Label;Lactoylglutathione Lyase;Leaky Gut;Link;lipid biosynthesis;lipid metabolism;Lipids;Liver;liver injury;Measures;Mediating;Metabolic;Metabolic syndrome;Metabolism;Mission;Mitochondria;Modeling;Modification;multiple omics;Mus;Muscle;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;Obesity;obesogenic;Oral;Output;Overweight;oxidation;Pancreas;Pathogenesis;Patients;pharmacologic;Phosphorylation;Physiological;Post-Translational Protein Processing;Prediabetes syndrome;Prevalence;Process;Proxy;Pyruvaldehyde;Reader;recruit;Research;Respiration;response;Role;sensor;Signal Transduction;Site;Stable Isotope Labeling;Sucrose;sugar;systemic inflammatory response;Testing;Thinness;Tissues;transcriptome sequencing;Triglycerides;United States;uptake;Weight Gain;Wild Type Mouse

PROJECT_TITLE: Glyoxalase 1 and its Role in Metabolic Syndrome

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Immunotherapy;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: COLLEGE STATION

ORG_NAME: ASTERO ERADO INC

PHR: PROJECT NARRATIVE Treatments that are currently available for antibody-mediated autoimmune diseases such as membranous nephropathy are generally immunosuppressive, are associated with adverse events and/or have limited efficacy. To address this issue, in this application we propose to develop a novel treatment that selectively removes the autoreactive antibodies which are involved in the disease process, without affecting the levels of other antibodies that are important for protection against infectious agents such as bacteria and viruses. This approach has the potential to be a game-changer for the clinical management of membranous nephropathy.

PI_NAMEs: KANNANGANAT SIDHARTHAN, SUNIL  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Address;Adult;Adverse event;Affect;Aftercare;Alkylating Agents;allergic response;Allografting;Alternative Therapies;Animal Model;Antibodies;Antibody Therapy;Antigens;Autoantibodies;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Bacteria;Behavior;Binding;Biological Markers;Calcineurin inhibitor;Cell Surface Receptors;Cessation of life;Chimeric Proteins;Chlorambucil;Clinical;clinical development;Clinical Management;Clinical Trials;commercialization;Cyclophosphamide;design;Development;Diabetes Mellitus;Diagnosis;diagnostic biomarker;Disadvantaged;Disease;Disease remission;DNA;Dose;drug development;Drug Kinetics;drug testing;End stage renal failure;Endothelial Cells;Engineering;Excision;Failure;first-in-human;Foundations;Funding;Generations;Goals;Human;Immune Tolerance;Immunoglobulin G;Immunosuppression;Immunosuppressive Agents;improved;improved outcome;In Vitro;in vitro Assay;in vivo;Infection;infection risk;Infectious Agent;Kidney;Kupffer Cells;Laboratories;Lead;Liver;Lymphoid Tissue;Lysosomes;Malignant Neoplasms;Mediating;Membranous Glomerulonephritis;MS4A1 gene;mycophenolate mofetil;Names;neonatal Fc receptor;Nephrotic Syndrome;new technology;nonhuman primate;novel;novel strategies;novel therapeutics;Osteoporosis;Pathogenicity;Patients;Phase;Phospholipase A2;Plasmablast;podocyte;Preparation;Procedures;Process;Production;Prognosis;prognostic;Property;Proteinuria;Reagent;receptor;Regimen;Relapse;relapse prevention;Research;Resistance;rituximab;Role;side effect;Spontaneous Remission;Steroids;Tacrolimus;targeted delivery;Technology;Texas;Therapeutic;Thrombocytopenia;Transgenic Mice;Universities;Virus;ward;Work

PROJECT_TITLE: Depleting autoantibodies for the treatment of autoimmunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-U(10)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Palliative Care;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The homeless population is aging, with an increasing proportion of individuals over age 50 who experience accelerated aging, high rates of mortality, and a high risk of not having their wishes honored at the end of life. The goal of this proposal is to test the effectiveness of adapted evidence-based advance care planning (ACP) interventions (i.e., an easy-to-read advance directive, an ACP group visit guide, and an ACP one-on-one facilitation guide) for formerly chronically homeless older adults living in Permanent Supportive Housing. The proposed project will compare the effectiveness of facilitated group versus one-on-one ACP visits in a Hybrid (NIH Stage III efficacy/effectiveness), Type 1, two-arm, cluster randomized trial with the goal of reducing health disparities in ACP among formerly chronically homeless older adults.

PI_NAMEs: KUSHEL, MARGOT B (contact);SUDORE, REBECCA L

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Address;Adoption;Adult;Advance Care Planning;advanced directive;Age;age acceleration;Age Years;Aging;Anxiety;arm;Attention;behavior change;behavior change wheel;Caring;Chronic;Chronic Disease;Cluster randomized trial;community advisory board;compare effectiveness;Consolidated Framework for Implementation Research;contextual factors;Death Rate;Decision Making;design;digital;Disabling condition;Disparity;Effectiveness;Effectiveness of Interventions;effectiveness testing;empowerment;end of life;evidence base;Evidence based program;experience;Face;Family;Feedback;fifth grade;Focus Groups;follow-up;Funding;Goals;health literacy;Healthcare;High Prevalence;high risk;high risk population;Homeless persons;Homelessness;Housing;Hybrids;implementation evaluation;implementation science;improved;Individual;Intervention;Intervention Trial;Interview;Left;marginalized population;Measures;Medical;member;Methods;Modeling;mortality;mortality risk;movie;novel;older adult;Participant;Patients;Persons;pet animal;Policies;Population;preference;Premature Mortality;Preparation;primary outcome;Process;programs;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Reading;Reduce health disparities;Reporting;Research;Resources;Sampling;secondary outcome;Services;Site;Social isolation;supported housing;Surveys;Testing;theories;Time;tool;trial comparing;United States National Institutes of Health;uptake;Visit;Work;Writing

PROJECT_TITLE: Empowering Formerly Homeless Older Adults to Engage in Advance Care Planning in Permanent Supportive Housing (ACP-PSH): An RCT

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: JACKSONVILLE

ORG_NAME: UNIVERSITY OF NORTH FLORIDA

PHR: Project Narrative A diverse cross-disciplinary workforce highly trained in biomedical sciences is critical for addressing global health concerns. Training of students from underrepresented (UR) ethnic/racial minority and economically disadvantaged groups that matriculate into PhD or MD/PhD programs will help create a diverse biomedical sciences workforce for the Nation. This proposal aims to meet the unmet needs of diversity of the next generation of research scientists by enabling U-RISE trainees to achieve their potential.

PI_NAMEs: ELLIS, TERRI NOELLE (contact);MALCOLM, HANNAH R

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Academic Medical Centers;Academic support;Bachelor's Degree;Biology;bridge program;Chemistry;Clinic;cohort;Collaborations;Communication;Development;Doctor of Philosophy;Early identification;economic disparity;Economically Deprived Population;Environment;Ethnic Origin;Evidence based intervention;experience;Financial Support;Florida;Fostering;Foundations;Graduation Rates;Immersion;Institution;inter-institutional;matriculation;Mentors;Minority;Mission;Outcome;outreach;peer coaching;Physics;programs;racial minority;Readiness;Research;Research Training;responsible research conduct;Science;skills;Student Persistence;Student recruitment;student retention;Students;summer internship;summer research;Support System;Training;undergraduate research;Underrepresented Populations;Underrepresented Students;Universities

PROJECT_TITLE: U-RISE at University of North Florida

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Identifying early markers of mild cognitive impairment (MCI) and Alzheimer’s disease and related dementias (ADRD) is a national priority. This study aims to develop sensitive, practical, and ecologically acceptable life- space mobility digital indicators that could be used as clinically relevant markers of subsequent cognitive decline among community-dwelling older adults and to examine the influence of social health in the relationship between life-space mobility and cognitive function. The findings from this study will help us design community-based programs to support early detection of cognitive decline and provide highly effective interventions to modify the trajectory of cognitive decline as early as possible.

PI_NAMEs: CHUNG, JANE ;SARGENT, LANA  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: actigraphy;Affect;aging population;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Area;Attitude;Behavioral;Biological Markers;biomarker identification;burden of chronic illness;Case/Control Studies;Characteristics;Classification;Clinical;clinically relevant;Cognitive;cognitive change;cognitive function;Communities;community based research;Complex;Computers;Consumption;Data;data visualization;Dementia;dementia burden;dementia risk;Detection;Deterioration;Diagnosis;digital;Digital biomarker;digital health;digital measure;digital technology;digital tool;early detection biomarkers;Early Diagnosis;Early identification;Early treatment;effective intervention;ethnic minority;ethnic minority population;Evaluation;Exhibits;follow-up;Frequencies;functional decline;functional status;Global Positioning System;Goals;Health;health care availability;health disparity;Health Status;Health Technology;human old age (65+);Impaired cognition;implementation barriers;improved;Individual;insight;Intention;interest;Interview;Life;Loneliness;Longitudinal Studies;Low income;low socioeconomic status;Measurement;Measures;medically underserved;Medicare claim;Methods;mild cognitive impairment;modifiable risk;Monitor;Movement;neuroimaging marker;Neuropsychology;older adult;Participant;Performance;Physical activity;Population;portability;preference;prevent;Prevention;Privacy;programs;prospective;Public Health;Race;racial minority;racial minority population;real time monitoring;recruit;Resources;Risk;Risk Factors;Role;sedentary;sensor;social;social influence;Social isolation;socioeconomics;Specific qualifier value;Speed;Surveys;Symptoms;Technology;Time;tool;Translations;Travel;trend;Visit;wearable device;willingness;Work;Wrist

PROJECT_TITLE: Life-Space and Activity Digital Markers for Detection of Cognitive Decline in Community-Dwelling Older Adults: The RAMS Study

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The study will fill a scientific gap in understanding of non-Hispanic Blacks demand for and access to innovations in AD/ADRD therapeutics and subsequent health and economic outcomes by (1) applying innovative mixed methods in data collection and analysis of demand; (2) utilizing dynamic microsimulation to quantify the health, quality-of-life and economic impacts. The study will change how we prepare for a future with novel and repurposed dementia therapeutics that supports equitable access for improved long-term health and economic outcomes.

PI_NAMEs: BENNETT, DAVID ALAN;ZISSIMOPOULOS, JULIE M (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Acceleration;access restrictions;Acute;Adherence;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer's disease therapeutic;American;barrier to care;black men;Black Populations;Black race;black women;burden of illness;California;Caring;caucasian American;Chronic;Cognitive;cohort;Communities;community engaged research;community engagement;Community Outreach;Complex;cost;Data;Data Analyses;Data Collection;Data Sources;Dementia;dementia burden;dementia risk;design;Development;Diagnosis;disorder risk;Disparity;distrust;Drug Prescriptions;drug repurposing;economic impact;economic outcome;Economics;Ensure;Environmental Risk Factor;Equity;ethnic minority;evidence base;experience;Face;Focus Groups;follow-up;Future;Goals;Health;Health Care Costs;health disparity;health equity;Healthcare Systems;high risk;Hispanic Populations;Improve Access;improved;innovation;Intervention;Measurement;Measures;Medical;Medicare claim;member;Methods;minority communities;Modeling;models and simulation;multidisciplinary;Not Hispanic or Latino;novel;novel therapeutics;older adult;Online Systems;Outcome;Participant;Patient Recruitments;Persons;Pharmaceutical Preparations;physical conditioning;Population;Population Heterogeneity;preference;prevent;programs;Public Health;Publications;Quality of life;racial minority;recruit;Research;Resource Sharing;Risk Reduction;Safety;Sampling;side effect;simulation;social culture;Specialist;stakeholder perspectives;Structural Racism;Surveys;System;Therapeutic;tool;Uncertainty;United States;Universities;uptake;user-friendly

PROJECT_TITLE: Use and Impact of Novel and Repurposed Therapeutics for Alzheimer's Disease and Related Dementia in Diverse Populations


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: NEWARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NEW JERSEY INSTITUTE OF TECHNOLOGY

ORG_STATE: NJ

PHR: Project Narrative The New Jersey Institute of Technology (NJIT) is an R1 research-active public university with an educational mission of providing students with research training and mentorship to produce the future generation of scientists and engineers. The goal of this training proposal is to develop a 3 year biomedical research immersion program, focusing on engaging students from all racial and ethnic backgrounds, national origins, gender preferences and abilities. The intended outcomes are to establish a didactic multidisciplinary research training program integrated with academics, enhance the diversity of participation in research, increase competitiveness of trainees, and through successful mentorship, encourage students to consider an academic or professional degree in the biomedical field (i.e. PhD, MD/PhD).

PI_NAMEs: BORGAONKAR, ASHISH D;PFISTER, BRYAN J. (contact);SADIK, OMOWUNMI A;SHEKHAR, PRATEEK ;SOARES, DAPHNE

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Biochemistry;Biological Sciences;Biomedical Engineering;Biomedical Research;Biomedical Technology;career development;cohort;Country;Degree program;Economics;Engineering;Environmental Science;ethnic diversity;experience;Fellowship;Fostering;Future;Future Generations;gender preference;Goals;Immersion;Mentorship;Mission;Modeling;National origin;New Jersey;outreach;Population Heterogeneity;programs;Race;Research;research based learning;Research Training;Science;Science, Technology, Engineering and Mathematics Education;Scientist;Self Direction;self-directed learning;skills;STEM field;Structure;student participation;Students;success;Technology;Time;Training;Training Programs;undergraduate student;Underrepresented Populations;Universities;Vision;Woman

PROJECT_TITLE: U-RISE at the New Jersey Institute of Technology

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Sarcoidosis;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Sarcoidosis is a multisystem inflammatory disease that is known to cause disproportionate morbidity to Black patients, and no interventions have been developed or tested to address this known disparity. We will utilize validated patient reported outcome measures to characterize the prevalence of patient reported barriers to care, their association with outcomes, and the impact of race on these associations. We will use community- based research to develop and pilot an intervention to address the most prevalent and harmful barriers to care in Black sarcoidosis patients, in keeping with the NIMHD's research interests of epidemiological research on population intersectionality and community-based intervention adaptation research.

PI_NAMEs: HARPER, LOGAN  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Acceleration;Activities of Daily Living;Adaptation research;Address;Affect;Anxiety;authority;Award;barrier to care;black men;black patient;Black race;black women;career;Career Choice;Caring;Child Care;Cluster randomized trial;Collaborations;Communication;Communities;community advisory board;community based participatory research;community based research;community collaboration;community intervention;cost;Data;design;Development;Diagnosis;Disease;Disease Outcome;disorder control;Disparity;epidemiology study;experience;Fatigue;Focus Groups;Foundations;Funding;Future;Goals;Health;health care disparity;Health Disparities Research;health disparity;Hospitals;improved;improved outcome;Income;Inflammatory;interest;intersectionality;Intervention;Interview;K-Series Research Career Programs;Knowledge;Low income;Measures;Mediator;Medical;Medical Care Team;medication compliance;medication nonadherence;Mental Depression;Mentors;Morbidity - disease rate;multidisciplinary;National Institute on Minority Health and Health Disparities;novel;Ohio;Outcome;Outcome Measure;Patient Care;patient oriented;Patient Outcomes Assessments;patient registry;Patients;peer;perceived discrimination;Pharmaceutical Preparations;Physicians;pilot test;Policy Maker;Population;Preparation;Prevalence;programs;prospective;Provider;public health insurance;Qualitative Methods;Quality of Care;Quality of life;Questionnaires;Race;Randomized, Controlled Trials;Reduce health disparities;Regimen;Registries;Reporting;Research;Research Design;Research Personnel;Research Proposals;Research Technics;Sample Size;Sarcoidosis;satisfaction;Scientist;Self Efficacy;side effect;Site;skills;social factors;Social support;Stress;Structure;Supervision;Surveys;System;Testing;therapy design;therapy development;Training;Transportation;trial design;uptake;Work

PROJECT_TITLE: Improving Black sarcoidosis patients’ care with a collaboratively developed, patient centered program


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Invasive fungal infections are some of the most dreaded infections for immunocompromised patients. This application seeks to understand how type I interferons, important molecules in the innate immune system, control the outcome of fungal infections.

PI_NAMEs: VYAS, JATIN M (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Affect;Anti-fungal Antibiotics;Applications Grants;Candida;Candida albicans;candidemia;Candidiasis;CD86 gene;cell type;Cells;chemokine;CISH gene;Clinical;Complex;cost;cytokine;Data;Death Rate;dectin 1;Dendritic Cells;Endosomes;Exposure to;Feedback;functional genomics;Gene Family;Genes;Glucans;Goals;Hospitalization;Hospitals;Host Defense;Human;Immune;Immune response;Immune system;Immunocompromised Host;immunopathology;immunoregulation;improved;in vivo Model;Infection;Inflammation;Innate Immune System;Interferon Activation;Interferon alpha;Interferon Receptor;Interferon Type I;Interferons;Intravenous;IRF3 gene;Knock-out;Knowledge;Licensing;Ligation;Macrophage;Macrophage-1 Antigen;Mediating;Microarray Analysis;Modeling;monocyte;mortality;Mus;Mutant Strains Mice;Mycoses;neutrophil;new therapeutic target;Outcome;particle;pathogen;Pathogenesis;pathogenic bacteria;pathogenic virus;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Phagocytes;Phagosomes;Phosphorylation;Play;Polystyrenes;Predisposition;Production;Proteome;receptor;recruit;Regulation;Resistance;response;Role;Sepsis;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Stimulator of Interferon Genes;TBK1 gene;Tissues;TLR7 gene;TNFRSF5 gene;trafficking;Ubiquitination;Up-Regulation;viral DNA;Work

PROJECT_TITLE: Control of Type I Interferon Production in Response to Candida albicans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)M]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Data Science;Digestive Diseases;Genetics;Human Genome;Microbiome;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: NARRATIVE It has been increasingly recognized that the gut microbiome is associated with colorectal neoplasia; however, the carcinogenesis mechanisms are not clear. This is the first large population-based study that utilizes a multi- omics approach to investigate microbiome-host interplays in the etiology of colorectal neoplasia. The findings will improve our understanding of how microbiome-host interactions impact the development of colorectal neoplasia and have translational potential to develop new tools for CRC prevention.

PI_NAMEs: YANG, YAOHUA  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Aberrant DNA Methylation;adenoma;Affect;Bacteroides fragilis;Bioinformatics;Biometry;Cancer Biology;Cancer Etiology;Carcinogenesis Mechanism;Cell Line;Cessation of life;cohort;Cohort Studies;Colon;colon carcinogenesis;Colorectal;Colorectal Adenoma;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;Colorectal Neoplasms;Colorectal Polyp;Communities;Data;design;Development;Diagnosis;Diagnostic;Dietary Practices;DNA;DNA Methylation;dysbiosis;Epidemiology;epidemiology study;Etiology;fecal microbiome;Fusobacterium nucleatum;Gene Expression;Gene Expression Profile;gut microbes;gut microbiome;gut microbiota;host microbiome;Human;improved;K-Series Research Career Programs;Knowledge;Link;Malignant Neoplasms;Mediation;Mentors;methylome;Microbiology;microbiome;mouse model;Multiomic Data;multiple omics;novel;Obesity;Parents;Participant;Pathway interactions;Patients;Phase;Play;Population Study;Preparation;prospective;Prospective, cohort study;Research Personnel;Resources;Risk;Risk Factors;Role;skills;stool sample;Students;Tennessee;Tissue Sample;Tissues;tool;Training;transcriptome;translational potential;tumor growth;Tumor Tissue;United States

PROJECT_TITLE: Dissecting roles of microbiome-host interactions in colorectal neoplasia etiology using multi-omics data

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: MH

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Genetics;Mental Health;Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Astrocytes are a glial subtype that associate intimately with neural circuits and are essential for brain function, but we know very little about how they grow, form contacts with neurons, and regulate dynamic changes in morphology. A deep understanding of how astrocytes regulate their elaborate morphologies and associate with neurons will be essential to study their basic functions, and how dysregulated growth can occur in human disease. This proposal will use Drosophila to characterize the fine details of astrocyte subcellular architecture, and identify and characterize novel conserved signaling pathways regulating astrocyte growth, maintenance and function.

PI_NAMEs: FREEMAN, MARC R (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adult;Affect;Animal Behavior;Animals;Architecture;Astrocytes;Behavior;Biology;biomarker validation;Brain;Brain Diseases;brain health;Brain Neoplasms;cell growth;cell type;Cells;Cellular Morphology;Cellular Structures;Childhood;Collection;Communication;Complex;Development;Disease;Drosophila genus;Educational process of instructing;Equilibrium;Exhibits;fly;forward genetics;Foundations;Genes;Genetic;genetic analysis;genetic approach;Genetic Screening;Genetic study;Glioblastoma;Goals;Growth;Human;human disease;imaging modality;in vivo;Individual;Infiltration;insight;Ions;Label;Light;Maintenance;Malignant Neoplasms;Mammals;Metabolic;model organism;Modeling;Molecular;Molecular Genetics;Morphogenesis;Morphology;Mus;Mutagenesis;mutant;Nature;Nervous System;neural circuit;Neuroglia;Neurons;Neuropil;neurotransmitter reuptake;Neurotransmitters;novel;Organelles;Organism;Pathway interactions;Phenotype;Play;Positioning Attribute;Process;programs;Proliferating;Property;Rapid screening;Research;Resolution;Role;screening;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;single cell analysis;Structure;Synapses;synaptogenesis;System;Technology;tool;Work

PROJECT_TITLE: How do you build an astrocyte?

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Human Genome;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE Genetic mutations in the tumor suppressor BRCA2 engender defects in DNA repair to ultimately cause cancer, and many of these variants still harbor unknown effects on BRCA2 function. Understanding how the DNA-binding domains in BRCA2 contribute to DNA repair would advance our knowledge of how mutations in these domains compromise genomic stability and lead to cancer development. These studies will lay the foundation for future endeavors to devise efficacious cancer treatment regimens.

PI_NAMEs: NEAL, FRANCISCO  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Affect;Affinity;Attenuated;Binding;Biochemical;Biological;Biological Process;biophysical analysis;Biophysics;Breast;C-terminal;Cancer Biology;Cancer Etiology;cancer therapy;cancer type;Cause of Death;Cells;Chromatids;clinically relevant;Complex;crosslink;Data;Defect;defined contribution;design;Development;DNA;DNA Binding;DNA Binding Domain;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Disorder;DNA replication fork;DNA Sequence Alteration;DNA Structure;DNA-Binding Proteins;Double Strand Break Repair;ds-DNA;Exhibits;experimental study;Fanconi's Anemia;Fellowship;Filament;Fostering;Foundations;Future;Gene Mutation;Genetic;Genetic Recombination;Genetic study;Genome;genome integrity;Genome Stability;Genomic Instability;Germ-Line Mutation;homologous recombination;Impairment;Inherited;Invaded;Knowledge;Lead;Left;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediator;Methods;Mutation;neoplastic cell;Neoplastic Cell Transformation;novel;Nucleoproteins;Ovarian;Pancreas;Pathway interactions;Physicians;Play;Predisposition;preservation;Process;Rad51 recombinase;recombinational repair;replication stress;Research;Research Personnel;Role;Scientist;Single-Stranded DNA;Specificity;stem;Structure;success;Syndrome;synergism;Testing;Therapeutic;tool;Training;Treatment Protocols;Tumor Suppressor Proteins;tumorigenesis;United States;Variant;Work

PROJECT_TITLE: Investigating contributions of BRCA2 DNA-binding domains toward maintaining genome integrity


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Deterioration of speech and language abilities is the main manifestation of primary progressive aphasia (PPA) and a frequent symptom in related neurodegenerative disorders, such as frontotemporal and Alzheimer's dementias. This proposal will use neuroimaging analyses and multilingual cognitive assessments to detect and diagnose speech and language impairment in diverse patient populations. These methods will provide new knowledge regarding the neural basis of speech and language and result in better detection, refined diagnosis and improved treatments for individuals with speech and language symptoms due to PPA and related neurodegenerative disorders.

PI_NAMEs: DELEON, JESSICA ANNE (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: accurate diagnosis;Address;Age;Age of Onset;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;American;Amyloid;Aphasia;apolipoprotein E-4;Atrophic;Autopsy;autosome;Behavioral;bilingualism;Biometry;California;career;carrier status;Classification;Clinical;clinical phenotype;Clinical Trials;Cognitive;cognitive reserve;cognitive testing;cohort;Data;Deposition;Detection;Deterioration;Diagnosis;Diagnostic;diagnostic criteria;Diffusion Magnetic Resonance Imaging;Disease Progression;dominant genetic mutation;Environment;Evaluation;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Genes;Genetic;genetic risk factor;Goals;gray matter;Heterogeneity;Imaging Techniques;improved;in vivo;Individual;K-Series Research Career Programs;Knowledge;Language;Language Disorders;language impairment;Life;Linguistics;Longitudinal Studies;Measures;Memory;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Molecular;molecular pathology;morphometry;multidisciplinary;Multilingualism;Multimodal Imaging;multimodal neuroimaging;Mutation;neural;neural network;Neuroanatomy;Neurobehavioral Manifestations;Neurodegenerative Disorders;neurogenetics;neuroimaging;Neurologist;neuropathology;novel;Onset of illness;Pathologic;Pathology;patient population;Patients;Pattern;Phenotype;Population;Population Heterogeneity;Positioning Attribute;Positron-Emission Tomography;predictive signature;Primary Progressive Aphasia;Production;Progressive Aphasias;Psychologist;Publishing;recruit;Research;Research Design;Research Personnel;Resources;risk variant;Role;San Francisco;Scientist;Severity of illness;skills;Spanish;Speech;Statistical Data Interpretation;success;Symptoms;Syndrome;syntax;Techniques;theories;Therapeutic;Time;Training;treatment trial;Typology;Universities;Variant;white matter

PROJECT_TITLE: Primary Progressive Aphasia: Beyond the Clinical Variants

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Coronaviruses;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases

ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE This project concerns the development and application of multiscale simulation methods to study viral replication in collaboration with experimental structural biologists and biochemists. The specific systems to be studied are implicated in the innate immune response, viral capsid properties, infection of HIV, and SARS- CoV-2 transmission. The findings from this work will advance fundamental knowledge in molecular simulation, virology and biophysics and have the potential to aid in the development of new antiviral strategies.

PI_NAMEs: YU, ALVIN  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: 2019-nCoV;ACE2;Adopted;Arginine;Award;Behavior;Binding;Biological Process;Biophysical Process;Biophysics;Capsid;career;Cells;Cellular biology;Charge;Chemicals;Collaborations;combat;Complex;Computer Simulation;COVID-19;Cryo-electron tomography;Data;Development;dimer;Disease;Elements;Event;Extracellular Space;Fullerenes;gag Gene Products;Genetic Materials;Goals;Grain;Heterogeneity;HIV;HIV Infections;Hybrids;Image;Immune;Infectious Agent;inhibitor therapy;Innate Immune Response;insight;Kinetics;Knowledge;Length;Letters;Life Cycle Stages;Link;Macaca mulatta;Mechanical Stress;Methodology;Methods;Modeling;models and simulation;Molecular;Molecular Conformation;molecular dynamics;molecular mechanics;molecular modeling;molecular scale;Morphology;novel therapeutic intervention;Nucleotides;Organism;pandemic disease;particle;Pattern;Peptide Hydrolases;Peptides;Phase;physical property;Physics;Phytic Acid;Play;Polyproteins;Process;Property;Protein Conformation;Proteins;quantum;quantum chemistry;Quantum Mechanics;receptor;receptor binding;Research;Reverse Transcription;Reverse Transcription Induction;Roentgen Rays;Role;Rupture;Sampling;SARS-CoV-2 spike protein;SARS-CoV-2 transmission;self assembly;sensor;Series;Signal Transduction;simulation;small molecule;Statistical Data Interpretation;Structural Biologist;structural biology;Structure;Surface;System;Tertiary Protein Structure;Testing;theories;Time;trafficking;Transcription Process;TRIM Motif;United States National Institutes of Health;Viral;Viral Genome;Virion;virology;Virus;Virus Diseases;virus genetics;Virus Replication;Work

PROJECT_TITLE: Theory and SImulation of Viral Replication

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Precision Medicine;Prevention

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Narrative  Efforts to improve oncology therapeutic outcomes will be greatly aided by the integration of early detection  and  new  precision  therapies,  reflected  by  the  significantly  improved  survival  rate  of  patients  with  metastatic  colorectal cancer (CRC) that is detected at an early stage when resection is especially effective. In light of the  lack  of  a  generalizable  approach  accessing  specific  diagnostic  biomarkers,  this  proposed  study  seeks  to  leverage  the  molecular  signatures  in  the  tumor  microenvironment  to  develop  multiplexed  in  vivo  sensors  for  precision diagnosis of cancer metastasis.  Successful completion of the proposed research program will exhibit  a preclinical framework of disease detection, stratifying and monitoring and will provide rationale for extending  this modular platform to the general context of cancer through tailored targets specificities.

PI_NAMEs: HAO, LIANGLIANG  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Address;Analytical Chemistry;Anatomy;Architecture;Area;Bar Codes;Benchmarking;Biological;Biological Assay;Biological Markers;Biology;Biosensor;Blood;cancer cell;cancer diagnosis;Cancer Etiology;Cancer Model;cancer type;Career Mobility;Cause of Death;cell motility;Characteristics;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Colorectal Cancer;colorectal cancer metastasis;colorectal cancer screening;Complement;Complex;CRISPR/Cas technology;delivery vehicle;Dependence;design;Detection;detection sensitivity;Development;Diagnosis;Diagnostic;diagnostic biomarker;diagnostic platform;Diagnostic Sensitivity;Diagnostic Specificity;Diffuse;Disease;disease classification;Disease stratification;DNA;Early Diagnosis;efficacy validation;empowerment;Engineering;Enzymes;Evaluation;Excision;Exhibits;experience;Extracellular Matrix;Fostering;Future;Generations;Genetic;Goals;Homing;Human;Image;Imaging Device;Imaging Techniques;Immune;Immunoglobulin Fragments;Implant;improved;In Vitro;in vivo;Injectable;innovation;interdisciplinary approach;Intervention;Invaded;Investigation;Lesion;Libraries;Light;Malignant Neoplasms;Medical;Medical Imaging;Mentors;metastatic colorectal;Modality;Molecular;molecular imaging;Molecular Profiling;Monitor;mortality;Mutation;nanobodies;nanosensors;Neoplasm Metastasis;Non-Invasive Detection;novel;novel strategies;novel therapeutics;Nucleic Acids;Oligonucleotides;Oncology;Operative Surgical Procedures;organoid transplantation;Paper;Patients;Peptide Hydrolases;Peptides;personalized approach;personalized diagnostics;point-of-care diagnostics;portability;Positron-Emission Tomography;pre-clinical;precision medicine;Precision therapeutics;Primary Neoplasm;programs;Property;Proteomics;Radiation;rational design;Recombinants;Reporter;Reporting;Research;Resource-limited setting;response;Sampling;scaffold;sensor;Signal Transduction;Site;Specificity;Survival Rate;technology development;Testing;theranostics;Therapeutic;therapy outcome;Time;tool;trafficking;Training;transcriptomics;translational potential;transplant model;treatment response;treatment strategy;tumor;tumor heterogeneity;tumor microenvironment;United States National Institutes of Health;urinary;Urine;Validation;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: Developing multiplexed microenvironmental sensors for precision diagnostics of cancer metastasis


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Contraception/Reproduction;Endometriosis;Neurosciences;Pain Research;Prevention;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Endometriosis-associated pelvic pain (EAPP), which often originates during adolescence, evolves into chronic pelvic pain in some women, leading to decreased quality of life and altered life trajectory impacting well into adulthood. The proposed research will leverage unique data from two longitudinal cohorts to identify proteins and pathways that confer increased risk of persistent pain in patients with endometriosis despite receiving current standard treatments. Results from this study will advance our understanding of the underlying mechanisms that contribute to pain and inform strategic selection of treatments and interventions in vulnerable patients before pain becomes entrenched.

PI_NAMEs: AS-SANIE, SAWSAN  (contact);TERRY, KATHRYN L.

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: Acute;Adolescence;Adolescent;adolescent woman;Adult;Adult women;Affect;Age;aged;associated symptom;Back;Basic Science;Biological;Biological Markers;Biological Specimen Banks;biomarker identification;Bladder;Blood;Blood specimen;Central Nervous System;Chronic;chronic pelvic pain;Clinical;clinical practice;cohort;common treatment;Complex;cost;Data;Development;Disease;Economics;Endometrial;endometriosis;Excision;experience;Fatigue;Female;Functional Magnetic Resonance Imaging;High Risk Woman;hormone therapy;Infertility;Inflammatory;inflammatory marker;innovation;Intervention;Intestines;Intractable Pain;Lesion;Life;Life Cycle Stages;Link;link protein;Longitudinal cohort;Magnetic Resonance Imaging;Measures;Michigan;Neurobiology;neuroimaging;Neuroimmune;novel marker;Operative Surgical Procedures;Pain;Pain Measurement;Participant;Pathway interactions;Patient Self-Report;Patients;Pelvic Pain;Peritoneal Fluid;Persistent pain;Phenotype;Plasma;Plasma Proteins;Prognostic Marker;Proteins;Proteomics;Protocols documentation;Quality of life;Questionnaires;Refractory;Reproducibility;reproductive;Reproductive Health;Research;Resistance;Risk;Sampling;Selection for Treatments;standard care;Symptoms;Testing;Time;Tissues;Treatment outcome;Universities;Uterus;Woman;Women's Health;young woman

PROJECT_TITLE: Novel biomarkers and pathways of persistent endometriosis-associated pain across the life course


NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative Although the FDA-approved BRAF and MEK inhibitors have reduced metastatic melanomas in some patients, these imprecisely targeted small molecule therapeutics have a low therapeutic index since they also alter normal cells, causing undesirable, even fatal, side effects. To address this serious drawback, we will develop a potent, tumor-selective MEK inactivator by engineering an anthrax toxin-based protein delivery system. We will employ a unique set of tumor stromal cell-type-specific anthrax toxin receptor-expressing mice and toxin targeting to unambiguously determine the role of MEK-ERK signaling in both the tumor and the stroma, thereby validating and identifying specific tumor stromal cell types as targets for future therapeutics development.

PI_NAMEs: LIU, SHIHUI  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Address;anthrax lethal factor;anthrax toxin;anthrax toxin receptors;Antigens;Antitumor Response;B-Lymphocytes;Binding;Biodistribution;Blood capillaries;BRAF gene;Brain;cancer cell;carcinogenicity;Cell Proliferation;Cell Survival;cell type;Cells;clinical development;clinical efficacy;Cytosol;Data;Development;Developmental Therapeutics Program;driver mutation;Endothelial Cells;Engineering;Ensure;FDA approved;Fibroblasts;Future;gain of function;Genetic;genetic manipulation;Goals;Human;in vivo;inhibitor;insight;KRAS2 gene;lethal factor;Link;loss of function;Malignant Neoplasms;MAP Kinase Gene;MAP2K1 gene;MAPK8 gene;Matrix Metalloproteinases;MEK inhibition;MEKs;Metastatic Melanoma;microbial;Modeling;Molecular;Morphogenesis;Mus;Mutation;Names;neoplastic cell;Normal Cell;novel;Oncogenic;p38 Mitogen Activated Protein Kinase;Pathogenesis;pathogenic bacteria;Pathway interactions;Patients;Peptide Hydrolases;Physiological;pre-clinical;Proteins;Ras/Raf;receptor;Regulatory T-Lymphocyte;Role;side effect;Signal Transduction;small molecule;small molecule inhibitor;small molecule therapeutics;Solid Neoplasm;Specificity;Stromal Cells;Stromal Neoplasm;System;Targeted Toxins;targeted treatment;Therapeutic;therapeutic development;Therapeutic Index;Tissues;Toxic effect;Toxin;tumor;tumor microenvironment;tumor specificity;Tumor-associated macrophages;tumorigenesis;Urokinase;Variant

PROJECT_TITLE: Developmental therapy for selectively targeting MEK-ERK pathway in cancer cells and tumor stromal compartment

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Lung;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: Project Narrative As preterm infant survival continues to improve, uncertainty regarding the best treatment for hemodynamically significant patent ductus arteriosus (HSPDA) can have serious public health implications for this vulnerable population. A novel, US Food and Drug Administration approved duct occluder (ADO-II AS) now offers clinicians a minimally invasive option for closing HSPDA, but its effectiveness in improving important patient outcomes, relative to supportive, non-interventional HSPDA management, is unknown. This project is relevant to NIH’s mission to understand the processes of human growth and development by determining via a multicenter randomized trial, whether percutaneous HSPDA closure using ADO-II AS improves cardiopulmonary and neurodevelopmental outcomes as compared to supportive, non-invasive therapy.

PI_NAMEs: BACKES, CARL  (contact);SLAUGHTER, JONATHAN LEE

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Adoption;Age;Arteries;artery occlusion;Belief;Birth;Brain;Brain Injuries;Cardiopulmonary;Cardiovascular system;Caregivers;Caring;Catheters;Cessation of life;Chronic lung disease;Circulation;Clinical;Complex;Consensus;Consent;Devices;Diameter;Duct (organ) structure;Effectiveness;efficacy study;Equipoise;Ethnic Origin;experience;Exposure to;extreme prematurity;Feasibility Studies;fetal;Gestational Age;Goals;Growth and Development function;Health Personnel;Heart;hemodynamics;Human;improved;in utero;Infant;Infant Health;Intensive Care;International;Intervention;Left;Legal patent;Link;Lung;Measures;Mechanical ventilation;Mediating;Medical;Medication Management;minimally invasive;Mission;Morbidity - disease rate;mortality;Neonatal;Neonatal Intensive Care Units;neonatal outcome;neurodevelopment;novel;Operative Surgical Procedures;Outcome;Output;Patent Ductus Arteriosus;Patient observation;Patient-Focused Outcomes;Patients;Peripheral;Pharmaceutical Preparations;postnatal;Pregnancy;Premature Infant;prevent;Procedures;Process;Public Health;Pulmonary artery structure;Pulmonary Hypertension;Race;Randomized;randomized trial;Randomized, Controlled Trials;recruit;respiratory;Respiratory Disease;Risk;Safety;secondary outcome;Severity of illness;sex;Site;specific biomarkers;Techniques;Testing;Thoracic cavity structure;trial comparing;Uncertainty;United States Food and Drug Administration;United States National Institutes of Health;Veins;Ventilator;Ventricular;Vulnerable Populations

PROJECT_TITLE: 1/2 percutaneous intervention versus observational trial of arterial ductus in lower gestational age infants (PIVOTAL)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cardiovascular;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Heart Disease;Immunotherapy;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CHARLESTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative Cytokine Storm is a complication from COVID-19 infection and is thought to induce acute cardiac injuries resulting in arrythmias, reduced ejection fraction, acute heart failure, and even death. While the prevalence has increased from the rising number of COVID19 cases worldwide, it is remains largely unknown how cytokine storm induces adverse cardiac events, and what long term effects this extreme inflammatory response has on the human myocardium. The goal of this study is to use 3D human cardiac organoids to model both the acute and long-term effects of COVID-19 induced inflammation on the heart.

PI_NAMEs: ARHONTOULIS, DIMITRIOS CHRISOVALANTOU (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: 3-Dimensional;Actinin;Acute;Address;adipose derived stem cell;Adrenergic Agents;Animals;Autopsy;Biological Models;Blood Vessels;Calcium Signaling;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cell Communication;Cells;Cessation of life;Chronic;Circulation;Clinical;Clinical Data;combat;Complication;Coronavirus;COVID-19;COVID-19 complications;COVID-19 cytokine storm;COVID-19 impact;COVID-19 mortality;COVID-19 patient;COVID-19 survivors;CSF3 gene;cytokine;cytokine release syndrome;Data;Death Rate;Dexamethasone;Diffusion;disease model;Dose;drug development;drug testing;EFRAC;Endothelial Cells;Event;experience;Fibroblasts;Genetic Transcription;Goals;Heart;Heart Abnormalities;Heart failure;heart function;Heart Injuries;Human;human induced pluripotent stem cells;Hypoxia;immune activation;immune modulating agents;Immune system;Impairment;In Situ Nick-End Labeling;in vitro Model;in vivo;induced pluripotent stem cell derived cardiomyocytes;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;insight;Interleukin-10;Interleukin-2;Interleukin-6;long term consequences of COVID-19;Long-Term Effects;Modeling;Monitor;monocyte;Myocardial Infarction;Myocardium;Norepinephrine;Organ;Organoids;Outcome;Outcome Study;Oxygen;PECAM1 gene;Persons;Pharmacotherapy;Phase;Prevalence;Production;Prognosis;Property;Recovery;Research;response;Role;Sampling;SARS-CoV-2 infection;Stimulus;Stromal Cells;Structure;Supporting Cell;System;Testing;Therapeutic Intervention;Toxic effect;transcriptome;transcriptome sequencing;Umbilical vein;Vimentin;Virus Diseases;VWF gene

PROJECT_TITLE: The Use of Human Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardiac Injury


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project narrative Three-dimensional human central nervous system tissues (e.g. organoids) derived from induced pluripotent stem cells are a powerful resource for understanding neurological/neurodegenerative diseases and the efficacy of prospective therapeutics. However, current brain organoid platforms do not have properly organized cells and lack vasculature, which limits their representativeness as a model system. This proposal will utilize engineering principles, including biomaterials synthesis and microfabrication techniques, to develop a brain organoid with organized cortical layers interspersed with capillary-sized blood vessels. This ‘neurovascular organoid’ is expected to be a significant improvement over existing organoid models.

PI_NAMEs: LIPPMANN, ETHAN  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: 3-Dimensional;Academic Medical Centers;Acute;Alzheimer's Disease;Alzheimer's disease risk;angiogenesis;Animal Model;Animals;Architecture;Biocompatible Materials;Biological Assay;Biological Models;Biomimetics;Blood - brain barrier anatomy;Blood capillaries;blood damage;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Brain;brain endothelial cell;Brain region;Cell Culture Techniques;Cell Line;Cells;Central Nervous System;Central Nervous System Diseases;Cerebral small vessel disease;cerebral vascularization;Chronic;Complement;Coupled;Cues;Data;density;Development;Disease;disease mechanisms study;disease model;disease phenotype;drug discovery;drug efficacy;Drug Evaluation;Drug toxicity;Drug usage;Electrophysiology (science);Endothelial Cells;Engineering;Epitopes;Exhibits;Functional disorder;functional outcomes;Gelatin;genetic risk factor;Genetic Variation;Genotype;Growth;Health;Human;Human Biology;human disease;human induced pluripotent stem cells;hydrogel scaffold;Hydrogels;Image;improved;In Vitro;in vitro Model;in vivo;in vivo Model;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;induced pluripotent stem cell technology;Injury;Investigation;Methacrylates;Microfabrication;Microvascular Dysfunction;mimetics;Modeling;Molecular;mouse model;N-Cadherin;Nerve Degeneration;neural;neural circuit;neural patterning;Neurodegenerative Disorders;Neuroglia;Neurologic;Neurons;neurovascular;neurovascular injury;novel;Organoids;Outcome Measure;Pattern;Peptides;Pericytes;Physiological;pluripotent stem cell differentiation;Polymers;prevent;Prosencephalon;prospective;Radial;Reperfusion Injury;Resources;response;Signal Transduction;Slice;Structure;Synapses;System;Techniques;Technology;Therapeutic;Time;Tissue constructs;Tissues;Toxicology;two-dimensional;Universities;Variant;vascular cognitive impairment and dementia;vascular contributions;Vascularization;Work

PROJECT_TITLE: iPSC-derived Neurovascular Organoids

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

PHR: Project Narrative The proposed research substantially advances our understanding of brain circuits that mediate cocaine relapse by exploring the role of newly characterized cell types. By applying innovative genetic and imaging technologies we will improve understanding of cocaine-induced neuropathology in the cell specific subcircuits regulating relapse and provide new drugable targets to inhibit relapse vulnerability.

PI_NAMEs: KALIVAS, PETER W (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Axon;Behavior;Brain;Brain region;cell type;Cells;Cocaine;cocaine craving;cocaine cue;cocaine relapse;cocaine seeking;cocaine self-administration;Code;Corpus striatum structure;Cues;Designer Drugs;Dopamine D1 Receptor;Dopamine D2 Receptor;Drug Addiction;Drug usage;Electrophysiology (science);Enkephalins;Enterobacteria phage P1 Cre recombinase;Excitatory Synapse;Extinction;FLP recombinase;gamma-Aminobutyric Acid;Genetic;genetic technology;Globus Pallidus;Glutamates;Grant;Imaging technology;improved;In Situ;in vivo;in vivo calcium imaging;Inhibitory Synapse;innovation;Knowledge;Label;lens;Measures;Mediating;Midbrain structure;Modeling;Motivation;Mus;Neurons;neuropathology;new therapeutic target;Nucleus Accumbens;Pathologic;postsynaptic;Presynaptic Terminals;receptor;Relapse;Reporter;Reporter Genes;Research;Rodent;Role;selective expression;Slice;Synaptic plasticity;Testing;Training;Transgenic Mice;Transgenic Organisms;Viral;Virus;Withdrawal;Work

PROJECT_TITLE: Glutamate and Craving for Cocaine

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Tuberculosis (TB) causes the largest number of deaths worldwide due to any single agent infectious disease. We propose a study that could help to diminish TB transmission in the region, identify new biomarkers of extent of disease, uncover new sites of TB transmission, and identify the bacterial genes associated with drug resistance.

PI_NAMEs: GILMAN, ROBERT H (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: acquired drug resistance;Age;Americas;Bacteria;Bacterial Genes;bacterial genetics;Biological Assay;biomarker identification;Cessation of life;Chest;Clinical;Collection;Communicable Diseases;Communities;community transmission;Confounding Factors (Epidemiology);Contact Tracing;Data;Data Set;Diagnosis;Disease;Disputes;Drug resistance;drug resistance development;Drug resistance in tuberculosis;Ecology;Event;Genetic;genetic association;Genetic Polymorphism;Genome;genome sequencing;genome wide association study;genomic biomarker;Genotype;Home;In Vitro;Incidence;Infectious Agent;Laboratories;Link;M. tuberculosis genome;Maps;Metadata;Monitor;novel;pathogen genome;Pathology;Patients;personalized medicine;Peru;Pharmaceutical Preparations;Phylogenetic Analysis;Phylogeny;Population;Population Heterogeneity;Predisposition;prevent;Questionnaires;Radiology Specialty;Sampling;sex;Site;socioeconomics;suburb;Techniques;Thoracic Radiography;Time;transmission process;Treatment Protocols;Tuberculosis;Variant;whole genome

PROJECT_TITLE: Using the Mycobacterium tuberculosis Genome to Predict Tuberculosis Pathology, Drug Resistance Acquisition and Identify Community Transmission Sites

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Glioblastoma (GBM) is incurable cancer with a dismal survival rate. Immunotherapy with genetically engineered antibodies such as bi-specific T cell engagers (BiTEs) has the potential to improve patient survival. This study will focus on understanding factors that influence BiTE efficacy, including tumor uptake, pharmacokinetics, and mechanism of action, and preclinically test and characterize a lead BiTE candidate for its use in treating GBM patients.

PI_NAMEs: BALYASNIKOVA, IRINA V (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Adult;Affect;Affinity;Animal Model;Animals;Antibodies;antibody engineering;Behavior;bi-specific T cell engager;Binding;Biodistribution;blood-brain tumor barrier;Brain;brain cell;cancer cell;Cancer Patient;CD3 Antigens;Cell Surface Receptors;Cells;chemotherapy;chimeric antigen receptor T cells;clinical application;Clinical Research;Clinical Trials;Combined Modality Therapy;cytotoxicity;Data;Dependence;Development;Drug Kinetics;Effectiveness;Engineering;Epidermal Growth Factor Receptor;epidermal growth factor receptor VIII;Failure;Flow Cytometry;Foundations;Future;Genetic;Genetic Engineering;Glioblastoma;Glioma;Granzyme;Human;human model;IL13Ralpha2;IL2 gene;Image;Immune;immune function;Immune response;Immune system;Immunocompetent;immunocytochemistry;Immunotherapy;improved;improved outcome;in vivo;Infiltration;Investigation;Knowledge;Knowledge acquisition;Lead;longitudinal positron emission tomography;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Microscopy;Modeling;Modification;mouse model;Mus;neoplastic cell;new therapeutic target;Newly Diagnosed;novel;Operative Surgical Procedures;Organ;Patients;Penetration;perforin;phase 1 study;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;Preclinical Testing;Process;Proteins;Protocols documentation;Radiation;rational design;Reagent;Recurrence;Research;Solid Neoplasm;Specificity;Survival Rate;T-Cell Activation;T-Lymphocyte;Testing;Testis;Tissues;TNF gene;Translating;Treatment Protocols;treatment response;tumor;Tumor Antibodies;Tumor Immunity;tumor microenvironment;uptake

PROJECT_TITLE: Understanding the Behavior of Novel IL13Ralpha2-directed T cell Engager for GBM

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Although standing balance control is typically an automatic, involuntary motor function, increasing attention to balance is common in many older adults and is an important fall risk factor. A major clinical barrier is that this engagement of brain activity in gait and balance is inferred through indirect behavioral methods, limiting early detection and targeted intervention approaches. Our proposal provides a novel scientific framework for directly measuring brain activity during balance tasks to enable mechanistic, personalized, approaches to maintain and improve balance health in aging as well as the many neurological and musculoskeletal diseases affecting balance health.

PI_NAMEs: BORICH, MICHAEL ROBERT;TING, LENA H (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Affect;Age;Aging;Anatomy;Attention;balance recovery;Behavior;Behavioral;Biological Markers;Biomechanics;Biometry;Brain;Brain imaging;Clinical;Clinical assessments;Cognitive;cognitive task;Compensation;Data;density;Disease;Dissociation;Early Diagnosis;Electrodes;Electroencephalography;Electromyography;Electrophysiology (science);equilibration disorder;Equilibrium;Fall prevention;fall risk;functional MRI scan;Gait;Gait abnormality;Goals;Health;Human;Impairment;improved;Individual;individual variation;innovation;Intervention;Kinetics;Lateral;Leg;leg paresis;Lesion;life span;Link;Measures;Mediating;Methods;Motor;Muscle;Musculoskeletal Diseases;Nervous System Disorder;Neurologic;Neuromechanics;neuromechanism;neuropathology;neurophysiology;novel;older adult;Orthopedics;Paresis;Performance;personalized intervention;personalized strategies;Phase;post stroke;precision medicine;Prevention strategy;prognostic tool;prospective;Publishing;Quality of life;Reaction;Resources;response;Risk Factors;Scientific Advances and Accomplishments;Sensory;Signal Transduction;Stroke;stroke rehabilitation;stroke survivor;Surface;Testing;Translations;Walking;young adult

PROJECT_TITLE: Individual-specific engagement of cortical resources for standing balance control in aging and post stroke


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Pediatric

ORG_CITY: ROCHESTER

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Severe Early Childhood Caries (S-ECC) is an infectious disease that continues to be a significant global public health problem among young, preschool children. The clinical, social and public health impact of S-ECC is underscored by its association with increased risk of new cavities in the primary dentition, a higher risk of cavities in the permanent dentition, hospitalizations and emergency room visits, high treatment costs, lost school days, diminished ability to learn and a profound impact on a child’s quality of life. Results of treatment of S-ECC are poor; approximately 40% of children treated for S-ECC will develop new cavities within 12 months after dental surgery. This proposal will assess the efficacy of topical antibacterial therapy in improving clinical outcomes for S-ECC.

PI_NAMEs: KOPYCKA-KEDZIERAWSKI, DOROTA T. (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: Acute;Address;anti-microbial drug;antimicrobial;Candida;Caregivers;Case Report Form;Case Study;Child;Clinical;Clinical Research;Code;Communicable Diseases;Counseling;Data;data management;Data Management Resources;Dental caries;Dental Enamel;Dental Hygiene;dental surgery;Detection;Disease;Distress;Double-Blind Method;early childhood;early onset;efficacy evaluation;efficacy study;Emergency department visit;Family;FDA approved;Feeding behaviors;Fluoride Varnishes;General Anesthesia;Health;Heterogeneity;high risk;Hospitalization;improved;Incidence;Instruction;International;Intervention;Lactobacillus;Learning;Lesion;lower income families;Manuals;Measures;Meta-Analysis;microbial;Mouth Diseases;National Health and Nutrition Examination Survey;novel;Nutritional;Operative Surgical Procedures;Oral;oral microbial community;oral microbiome;Outcome;permanent tooth;phase II trial;Placebo Control;Placebos;Povidone-Iodine;Preschool Child;Prevalence;prevent;Prevention;Preventive;Primary Dentition;primary outcome;Procedures;Protocols documentation;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Recurrence;Recurrent disease;Rehabilitation therapy;Reporting;Risk;Schools;Severities;social;standard of care;Streptococcus mutans;success;Surveys;System;Time;Tooth structure;topical anti-microbial;topical antibacterial;Topical Fluorides;Treatment Cost

PROJECT_TITLE: Povidone Iodine Efficacy Study (PIES)


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE In this proposal we will characterize the local and systemic anticancer immune activating properties of collagen- retained interleukins -2 and -12, in combination with radiotherapy by leveraging the inclusion of pet dogs with naturally-occurring cancers. With this information, we will develop rationally-designed and optimally scheduled combinatorial strategies that exert potent anticancer effects both locally and distantly (abscopal effect) for combating cancer progression. We will assess the safety, pharmacodynamic, immunobiologic activities, and anticancer effects of these immune-based strategies in relevant mouse models and pet dogs with solid tumors and oral melanoma to guide future translation studies in human patients diagnosed with advanced stage melanoma.

PI_NAMEs: FAN, TIMOTHY M;WITTRUP, KARL DANE (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Abscopal effect;Address;Agonist;Anatomy;Animal Hospitals;Animals;anti-cancer;Antigens;Area;Binding;Biological Assay;Biological Markers;Buffers;cancer immunotherapy;Cancer Model;cancer therapy;Canis familiaris;Cell Death;Cells;Chimeric Proteins;Clinical;clinical translation;Clinical Trials;Collaborations;Collagen;combinatorial;companion animal;Companions;comparative;cytokine;cytokine therapy;Cytology;Data;design;design,build,test;Diagnosis;Distant;DNA Damage;Dose;draining lymph node;drug distribution;Dyes;efficacy evaluation;Enzymes;Epigenetic Process;Evaluation;Event;Exclusion;Exhibits;experimental study;Extravasation;Fine needle aspiration biopsy;Flow Cytometry;Functional disorder;Future;Gene Expression;Generations;Genetic;Genetic Engineering;Guidelines;Heterogeneity;Human;Image;Immune;immune cell infiltrate;Immune system;immune-related adverse events;Immunophenotyping;Immunotherapeutic agent;Immunotherapy;improved;In Situ;Infiltration;Inflammatory;Injectable;Injections;Intention;Interferon Type II;Interleukin-1;Interleukin-12;Interleukin-2;Interleukin-6;irradiation;Learning;lipophilicity;Liquid substance;Malignant Neoplasms;Mechanics;Mediating;Melanoma;Metastatic Neoplasm to the Lung;Modeling;Monitor;mouse model;Mus;Myeloid-derived suppressor cells;nano-string;Needles;Neoplasm Transplantation;neoplastic cell;novel;Oncology;Oral Melanoma;Outcome;Patients;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Placebos;Plasma;Population;Pre-Clinical Model;preclinical evaluation;primary endpoint;Probability;Process;programs;Progression-Free Survivals;Property;Protein Engineering;Protocols documentation;Radiation;Radiation therapy;rational design;recruit;Regulatory T-Lymphocyte;Reporter;Research Personnel;Resected;retention rate;Safety;safety assessment;Sampling;Schedule;secondary endpoint;Site;Solid Neoplasm;sound;standard of care;systemic toxicity;T-Lymphocyte;Techniques;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Therapeutic Index;Time;TNF gene;translation to humans;translational study;Transplantation;Treatment Protocols;tumor;Tumor Leakage;tumor progression;Tumor Volume;Tumor-infiltrating immune cells;vaccine response;Veterinary Medicine

PROJECT_TITLE: Intratumoral Cytokine Immunotherapy Studies in Companion Canine Cancer Models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Alzheimer’s disease (AD), a devastating neurodegenerative disease, is estimated that 13.8 million Americans and 90 million people worldwide will be affected by 2050, without disease-modifying treatments. This project will develop capable and intelligent computer-based network medicine, electronic health record (EHRs), and multimodal single-nucleus genomic analytic tools along with functional validation using AD patient-induced pluripotent stem cells (iPSC) and iPSC-derived cerebral organoid and TREM2R47H knock-in mouse models for identifying TREM2 genotype-informed microglia-targeted therapeutics for AD. The successful completion of this project will identify novel aspects of the underlying immune mechanisms in TREM2R47H mutant AD human brains, leading to potential repurposable drugs and combination therapies to be tested in AD clinical trials directly. 1

PI_NAMEs: CHENG, FEIXIONG  (contact);GAN, LI ;WANG, FEI

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: 3-Dimensional;Affect;African American;Age;AKT inhibition;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapeutic;Alzheimer's disease therapy;American;Amyloid;Amyloid beta-Protein;analytical tool;Anti-Inflammatory Agents;Area;Asthma;Attention;bench to bedside;Biology;Brain;brain based;brain endothelial cell;candidate identification;Cell Line;Cell Nucleus;cell type;Cells;Cerebrum;Clinic;Clinical;clinical efficacy;Clinical Trials;cohort;Combination Drug Therapy;Combined Modality Therapy;Communication;Computers;Data;Databases;deep learning;Development;Disease;Disease associated microglia;Disease Outcome;Disease Progression;Dose;drug candidate;Drug Combinations;drug discovery;drug repurposing;Drug Screening;Drug Targeting;drug testing;Drug usage;Electronic Health Record;experimental study;fluticasone;Gene Targeting;Generations;Genes;Genetic;Genetic Transcription;Genome;genome-wide;genomic data;Genomics;Genotype;Health system;Human;human disease;Human Genetics;Immune;in vitro Assay;Incidence;induced pluripotent stem cell;Inflammation;Inflammatory;Intervention;Investigation;Knock-in Mouse;knowledge graph;Knowledge Portal;Late Onset Alzheimer Disease;Link;Machine Learning;Medicine;Methodology;Methods;metropolitan;Microglia;Molecular;Molecular Target;molecular targeted therapies;mouse model;multimodality;multiple omics;Mus;mutant;Mutation;Nature;Nerve Degeneration;Network-based;Neurodegenerative Disorders;Neuroglia;neuroinflammation;New York City;novel;Observational Study;Organoids;Pathogenesis;patient derived induced pluripotent stem cells;Patients;Penetration;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacologic;Pharmacotherapy;Play;Population;population based;preclinical efficacy;prevent;Process;Property;Research;Risk;risk variant;Role;side effect;Signal Transduction;single nucleus RNA-sequencing;Source;success;System;Systems Biology;targeted treatment;tau Proteins;Tauopathies;Testing;therapy design;Toxic effect;treatment effect;TREM2 gene;trial design;United States;Validation;Variant

PROJECT_TITLE: TREM2 Genotype-Informed Drug Repurposing and Combination Therapy Design for Alzheimers Disease