ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE This is a request for a new R25 award to support summer experiences at the Medical College of Wisconsin (MCW) in Milwaukee for undergraduate students from underrepresented groups (URGs) in science and medicine to receive hands-on cardiovascular research experiences, training in science-related skills, education about careers available in science, technology, engineering, and mathematics (STEM), and learn tools for breaking down barriers, thriving, and resilience that are tailored to the trainee’s intended career path of becoming a physician, a scientist, or working in another STEM-related career. MCW receives 200 to 300 more applications each spring semester from undergraduates from URGs than available summer positions so there is great need at MCW for federal support of this R25, and the MCW Cardiovascular Center has 36 well-trained, well-funded faculty mentors available within its four areas of research expertise in which to provide this training: 1) atherosclerosis, thrombosis, and vascular biology (plaque, blood clots, and blood vessel health), 2) cardiac biology and heart failure (heart structure and function), 3) cardio-oncology (cancer’s effects on heart and blood vessel health), and 4) hypertension (high blood pressure). At a time when the burden of cardiovascular disease continues to rise and the diversification of the biomedical workforce is greatly needed, our training program is designed to inspire and fully-equip our undergraduate trainees from URGs for future careers within STEM, especially in areas related to cardiovascular research, thereby enhancing the diversity of the future biomedical workforce.

PI_NAMEs: BENJAMIN, IVOR JAMES (contact);LINCOLN, JOY ;SIKER, MALIKA L

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Address;Advisory Committees;apprenticeship;Area;Atherosclerosis;Attitude;Award;Awareness;Bachelor's Degree;Behavior;Benchmarking;Biology;Blood coagulation;Blood Vessels;Cardiac;Cardiovascular Diseases;Cardiovascular system;career;Career Choice;Career Mobility;Cause of Death;clinical care;college;Competence;Degree Completion;Degree program;design;Detection;Disease;Doctor of Philosophy;Drops;Education;Education Projects;Educational process of instructing;Enrollment;Environment;experience;faculty mentor;Fellowship;Funding;Future;Goals;graduate school;Health;health equity promotion;Health Personnel;Heart;Heart failure;Hypertension;improved;innovation;Institution;Internet;Knowledge;Lead;Leadership;Learning;Malignant Neoplasms;Measures;medical schools;Medicine;Mentors;multidisciplinary;National Heart, Lung, and Blood Institute;next generation;Occupations;Oncology;Pathway interactions;Patient Self-Report;peer;personalized learning;Physicians;Population Scientist Supplement (R25);Positioning Attribute;Prevention;Professional Competence;programs;recruit;Reduce health disparities;Research;Research Personnel;resilience;Resources;Schools;Science;Science, Technology, Engineering and Mathematics;Scientist;Self Assessment;skills;STEM career;STEM field;STEM student;Structure;Student Persistence;Students;success;summer program;summer research;Surveys;symposium;Telephone;Thinking;Thrombosis;Time;tool;Training;Training Programs;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Waiting Lists;Wisconsin

PROJECT_TITLE: Advancing Student Potential for Inclusion with Research Experiences (ASPIRE)


ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Data Science;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: CINCINNATI

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative The NHLBI’s Bench to Bassinet Program (B2B) was launched to accelerate pediatric cardiovascular translational research from discovery to early translational testing to clinical testing. The B2B is comprised of the Pediatric Cardiac Genomics Consortium (PCGC), the Cardiovascular Developmental Biology Data Resource Center (CDDRC), and the Pediatric Heart Network (PHN). Objectives of the PCGC are to identify genetic causes of human congenital heart disease and to relate genetic variants present in the congenital heart disease patient population to clinical outcomes. The CDDRC will expand the use of data previously generated by the B2B Cardiovascular Development Consortium (CvDC) to a broader number of data scientists by assembling the data into a queryable data repository complete with computational tools. The Administrative Coordinating Center (ACC) provides the infrastructure to enhance collaborations among the PCGC, CDDRC, and the PHN to identify and facilitate the translational research process for the most important pediatric cardiovascular clinical care problems. Our proposed ACC to support the PCGC and CDDRC is a unique, integrated combination of world-leading pediatric cardiovascular clinical/translational research expertise, advanced infrastructure, outstanding institutional support, and state-of-the-art technology. We believe these strengths to be critical for an ACC to successfully partner with the B2B program and NHLBI in leading the coordination of knowledge and data for this important pediatric cardiovascular research effort.

PI_NAMEs: CNOTA, JAMES ;OLLBERDING, NICHOLAS J (contact);WAGNER, MICHAEL

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Acceleration;Adult;Basic Science;Bioinformatics;Candidate Disease Gene;Cardiovascular Diseases;Cardiovascular system;Child;Childhood;Clinic;Clinical;clinical application;clinical care;Clinical Data;Clinical Management;Clinical Research;Collaborations;Communities;computerized tools;congenital heart abnormality;Congenital Heart Defects;Data;Data Coordinating Center;data management;data repository;data resource;Data Science;Data Scientist;Data Set;data sharing;Development;Developmental Biology;Diagnosis;Epidemiology;Epigenetic Process;experience;FAIR principles;Funding;Genetic;genetic variant;genomic data;Goals;Heart;Human;improved;improved outcome;Individual;Infant;Infant Mortality;Informatics;Infrastructure;Institution;interoperability;Knowledge;Lesion;Medical;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;operation;Outcome;Output;patient population;Patient-Focused Outcomes;Patients;Pediatric Cardiac Genomics Consortium;Process;programs;Reproducibility of Results;Research;research clinical testing;Research Personnel;statistics;Structure;Surgical Management;Technology;Testing;Therapeutic;Translating;Translational Research;Variant;Work

PROJECT_TITLE: Administrative Coordinating Center:  Bench to Bassinet Program


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Microglia cells are the innate component of the brain’s immune system and have an important role in maintaining homeostasis of neuronal function under physiological condition and mediating an inflammatory response after neuronal injury. Ischemic stroke elicits a strong neuroinflammatory response characterized by massive microglia activation. The data gained in this research proposal will have important implications for developing novel therapeutic interventions to mitigate cerebral ischemia by targeting the modulation of the neuroinflammatory response following stroke via TGF-β signaling modulation.

PI_NAMEs: LUO, YU  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Ablation;Acute;Adult;Affect;Animal Behavior;Animal Model;Astrocytes;Autocrine Communication;Behavioral;Brain;brain tissue;Cause of Death;cell type;Cells;Central Nervous System Diseases;central nervous system injury;Cerebral Ischemia;Cessation of life;Chronic;chronic neurologic disease;Computing Methodologies;cytokine;Data;Development;disability;dosage;Evaluation;functional improvement;functional outcomes;Goals;Histologic;Homeostasis;Immune system;Impairment;in vivo;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;Innate Immune System;insight;interest;ischemic injury;Ischemic Stroke;Knock-out;Knockout Mice;Knowledge;Ligands;Maintenance;Mediating;Microglia;Neuroglia;neuroinflammation;Neuronal Injury;neuronal metabolism;neuronal survival;Neurons;novel;novel therapeutic intervention;Paracrine Communication;Pathologic;Pathology;Pathway interactions;pharmacologic;Phenotype;Physiological;Pilot Projects;Play;postnatal;Production;Proliferating;receptor;Recovery;Regulation;Research;Research Proposals;response;Rest;Role;Signal Transduction;small molecule;Societies;Source;Spatial Distribution;Stroke;stroke outcome;Synaptic plasticity;Testing;TGF Beta Signaling Pathway;TGF-beta type I receptor;TGFBR2 gene;Time;Tissues;transcriptomic profiling;transcriptomics;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors

PROJECT_TITLE: The role TGF-beta Signaling pathway in microglia and astrocytes homeostasis and cellular interactions

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Patient Safety;Pediatric;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Despite the known dangers of air pollution to children with asthma, physicians have few tools to identify and integrate information on a patient’s environmental and social stressors into clinical medicine. The goals of this research project are to understand the relationship between the following: 1) environmental estimates of air pollution and urinary air pollutant biomarkers, and 2) the role of biological and geospatial air pollutant markers, stress on asthma morbidity. Successful completion of this project will produce an Asthma Integrated Risk (AIR) Clinical Prediction model that incorporates these data sources in order to provide clinicians an effective tool to assess a patient’s integrated host, social and environmental risk for asthma morbidity and improve the health of inner city children with asthma.

PI_NAMEs: HAUPTMAN, MARISSA  (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Active Learning;Address;Adverse effects;Air Pollutants;Air Pollution;Area;Aromatic Polycyclic Hydrocarbons;Asthma;asthma exacerbation;asthma model;asthmatic patient;Bioinformatics;Biological;Biological Markers;biomedical informatics;Biometry;Boston;career;career development;Caring;catalyst;Characteristics;Child;Childhood;Childhood Asthma;Chronic;Chronic Disease;Clinical;clinical care;clinical center;clinical decision support;clinical decision-making;clinical implementation;Clinical Medicine;clinical predictive model;clinical predictors;Clinical Research;clinical risk;cohort;community-level factor;Computerized Medical Record;Dangerousness;Data;data repository;Data Sources;Development Plans;Disease;Electronic Health Record;electronic medical record system;Environment;Environmental Air Pollutants;Environmental Epidemiology;Environmental Exposure;Environmental Health;environmental intervention;Environmental Medicine;Environmental Pollutants;Environmental Risk Factor;environmental stressor;Epidemiology;experience;Exposure to;Family;Fellowship;Foundations;Funding;Future;Goals;Guidelines;Health;health disparity;Health Personnel;Health Professional;Health Services Research;high risk;Housing;Immunologics;improved;Individual;inner city;innovation;Institution;Institutional Review Boards;instructor;International;Intervention;Joints;Knowledge;knowledge integration;Measures;Medical;medical schools;meetings;Mentors;Mentorship;Methodology;Morbidity - disease rate;National Institute of Environmental Health Sciences;novel;novel therapeutics;Outcomes Research;patient population;Patients;Pediatric Hospitals;pediatric patients;pediatrician;Pediatrics;Physicians;Play;pollutant;Pollution;Population;Positioning Attribute;predictive tools;Predisposition;preventive intervention;programs;Public Health Schools;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Residencies;Resources;Risk;Risk Factors;Role;Schools;Science;Scientist;skills;social;social determinants;social stressor;Stress;Subgroup;Testing;Therapeutic;Therapeutic Intervention;Time;tool;traffic-related air pollution;Training;Translational Research;United States National Institutes of Health;urinary;Work

PROJECT_TITLE: Air Pollution, Stress and Asthma Morbidity Risk: Role of Biological and Geospatial Markers


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative: Tanzania faces an unfinished HIV testing, treatment, and viral suppression agenda because of implementation gaps, particularly in children, adolescents, and young adults and is also in the early stages in determining how to best integrate prevention, screening, and care for non-communicable diseases into HIV programs. The long-term success of HIV care and treatment programs and achievement of the HIV targets in Tanzania can be ensured and improved through the HIV Implementation Science training program – a joint initiative by the Harvard T.H. Chan School of Public Health in Boston and Muhimbili University of Health and Allied Sciences (MUHAS) in Dar es Salaam that will build research capacity on rigorous Implementation Science, Impact Evaluation, and Health Systems Research methods to test the performance of approaches, structures, and programs in the delivery of HIV interventions.

PI_NAMEs: FAWZI, WAFAIE W;KAMBI, MUHAMMAD BAKARI;MUGUSI, FERDINAND MUKAMA;SUDFELD, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Achievement;Adolescent and Young Adult;Affect;Africa South of the Sahara;Ally;Area;Boston;care systems;Caring;Child;Collaborations;Country;design;Disease;Doctor of Philosophy;Education;Educational process of instructing;Ensure;Epidemic;Face;Faculty;Government;Health;Health system;Heart;HIV;HIV-infected adolescents;HIV/AIDS;Human immunodeficiency virus test;Impact evaluation;implementation research;implementation science;improved;Joints;Master of Public Health;Medical;nutrition;Persons;Policy Maker;Postdoctoral Fellow;Prevention;Principal Investigator;programs;Public Health;public health intervention;Public Health Schools;Research;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Research Training;Resources;Science;screening;success;symposium;systems research;Tanzania;tool;Training;Training Programs;treatment program;treatment services;Universities;Viral;Work

PROJECT_TITLE: HIS : Training Tanzanian Researchers for HIV/AIDS Implementation Science (Renewal)


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Dementia;Neurodegenerative;Palliative Care

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: K07 Project Narrative With the number of U.S. family caregivers shrinking and the demands on their health and wellbeing increasing, we are facing a family caregiver public health crisis. By connecting new and established interdisciplinary researchers, we can spark new and innovative solutions for the benefit of family caregivers and their care recipients. This K07 Academic Leadership Career Award proposes to formalize connections and promote collaborations across disciplines and academic entities at the University of Utah and Utah Health Sciences to provide the necessary infrastructure, mentoring, content and methodologic expertise to improve the support of family caregivers of older adults.

PI_NAMEs: ELLINGTON, LEE A (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Affect;Aging;aging population;Alzheimer's disease care;Attention;Award;care recipients;career;Caregiver research;Caregiver well-being;Caregivers;caregiving;caregiving research;Caring;clinical center;Clinical Investigator;Clinical Sciences;Collaborations;collaborative environment;college;Consultations;curriculum development;Dementia;design;Development;disability;Discipline;Discipline of Nursing;Disease;Education;Educational Curriculum;Educational process of instructing;Emotional;Equity;Evaluation;experience;Face;Faculty;Family;Family Caregiver;family caregiving;Family Characteristics;Family Process;Family Research;family support;Fertilization;Fostering;Future;Goals;Health;Health Personnel;Health Professional;Health Sciences;improved;Infrastructure;innovation;Interdisciplinary Study;Investments;Knowledge;Leadership;Learning;Life;Malignant Neoplasms;Master of Science;Mental Health;Mentors;Mentorship;Methodology;multiple chronic conditions;next generation;novel;older adult;Outcome;Personal Satisfaction;physical conditioning;Population;programs;Public Health;Research;Research Activity;Research Personnel;Research Proposals;Resources;Scholarship;Science;Scientist;skills;social;Stream;synergism;Time;Training;Transcend;Translational Research;Universities;Utah;visiting scholar

PROJECT_TITLE: Research Collaborative for Family Caregivers of Older Adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Nanotechnology;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative: This application will develop a new combination therapy for the treatment of metastatic breast cancer through nanoparticles-mediated codelivery of iRhom1 siRNA and DOX-SAHA, a prodrug conjugate of doxorubicin (DOX) and SAHA.

PI_NAMEs: LI, SONG  (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Anthracycline;Antigen Presentation;Antineoplastic Agents;Apoptosis;Autophagocytosis;Biodistribution;Biomedical Engineering;BRCA mutations;Breast Cancer Model;Breast Cancer Patient;Breast Cancer therapy;cancer cell;Cancer Etiology;Cancer Patient;cancer type;Carcinoma;Cessation of life;Chemoresistance;chemotherapeutic agent;chemotherapy;Clinic;Combined Modality Therapy;cytokine;Data;Development;Doxorubicin;Drug resistance;Endoplasmic Reticulum;Endothelium;Enzymes;Epidermal Growth Factor Receptor;HIF1A gene;Homeostasis;Human;Hydrophobicity;Immune response;Immunotherapy;immunotherapy trials;improved;in vivo;Inflammatory;knock-down;Knock-out;Ligands;lipophilicity;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Membrane;Membrane Proteins;Metabolic Biotransformation;Metalloproteases;Metastatic breast cancer;Metastatic Neoplasm to the Lung;Modeling;molecular subtypes;Mus;nanocarrier;nanoparticle;Neoplasm Metastasis;neoplastic cell;new combination therapies;novel;novel strategies;Nucleic Acids;overexpression;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Play;Prodrugs;Prognosis;Proteins;Reporting;response;rhomboid;Role;Safety;Small Interfering RNA;small molecule;small molecule inhibitor;targeted delivery;targeted treatment;taxane;Therapeutic;therapeutic target;Tissues;TNF gene;Toxic effect;trafficking;transcytosis;translational therapeutics;Transmembrane Domain;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor xenograft;tumor-immune system interactions;United States;Vorinostat;Woman

PROJECT_TITLE: Nanoparticles-mediated combination therapy for breast cancer


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The active movement of proteins, vesicles, and organelles along the extended axons of neurons is called axonal transport, and is essential to maintain healthy motor and sensory neurons, which have axons that can extend up to a meter in humans. Defects in axonal transport cause neurodegeneration, and occur in diseases such as Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease) or Charcot-Marie-Tooth Disease. We are investigating the molecular mechanisms regulating axonal transport and organelle dynamics in neurons, and hope that our progress will provide new insights into the development of targeted therapeutic approaches in future.

PI_NAMEs: HOLZBAUR, ERIKA L (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Active Biological Transport;Affect;Afferent Neurons;Aging;Amyotrophic Lateral Sclerosis;Anabolism;Autophagosome;Axon;Axonal Transport;Cells;Charcot-Marie-Tooth Disease;Complement;Cytoplasm;Cytoskeletal Filaments;Cytoskeletal Modeling;Cytoskeleton;Defect;Development;Disease;Dynein ATPase;Exhibits;Future;genetic regulatory protein;Goals;Human;In Vitro;insight;interest;Kinesin;Lead;Length;live cell imaging;Membrane;meter;Mitochondria;Modeling;Molecular;Molecular Motors;Morphology;Motility;Motor;Motor Neurons;Movement;Nerve Degeneration;Neurons;Organelles;Pattern;presynaptic;Protein Biosynthesis;Proteins;reconstitution;Regulation;Resolution;Scaffolding Protein;single molecule;Site;Synapses;Synaptic Vesicles;targeted treatment;Testing;therapeutically effective;Time;Vesicle

PROJECT_TITLE: Molecular Mechanisms of Axonal Transport and Organelle Dynamics


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE Current imaging technologies are limited in their number of “channels” that can be used to observe cancers in detail. If one were able to image beyond the few limited number of channels in vivo, one could use imaging in completely new ways, analogous to the transformation that multiplexed flow cytometry has undergone over the last decade. This in turn would allow deciphering effects of drug action, resistance mechanism, immune cell responses and basic cancer biology in intact microenvironments. The goal of this proposal is to further develop a new bioorthogonal technology (SAFE-IVM) to enable ~30 channel in vivo imaging. The new method will allow us to perform in depth studies and will likely lead to new insight and experimental therapies in cancer.

PI_NAMEs: WEISSLEDER, MD, PHD, RALPH  (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: 3-Dimensional;Affect;Affinity;Antibodies;Benchmarking;Biological;Biology;Biomedical Research;Biotechnology;Cancer Biology;cancer therapy;cell behavior;Cell Mobility;Cells;cellular targeting;Chemistry;Color;Complex;Data;Development;drug action;Drug Delivery Systems;Dyes;Environment;experimental study;Feasibility Studies;Fingerprint;Flow Cytometry;Fluorochrome;Future;Goals;Gold;Image;imaging agent;imaging capabilities;Imaging technology;Immune;improved;In Vitro;in vivo;in vivo evaluation;in vivo imaging;insight;intravital imaging;intravital microscopy;Investigational Therapies;Kinetics;Label;Ligands;Magnetic Resonance Imaging;Malignant Neoplasms;Methods;microscopic imaging;Modernization;Molecular Profiling;Molecular Target;Motility;mouse model;multiplexed imaging;new technology;Noise;novel;Optics;Polymers;Positron-Emission Tomography;Proteins;Reaction;real-time images;Reporter;Residual state;resistance mechanism;Resolution;response;Science;Signal Transduction;single-cell RNA sequencing;small molecule;Stains;Stromal Cells;success;Techniques;Technology;technology validation;Testing;Time;Tissues;transcriptomics;tumor;tumor heterogeneity;tumor microenvironment;two-dimensional;validation studies;Viola;Visualization

PROJECT_TITLE: Bioorthogonal probe development for highly parallel in vivo imaging


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Periodontitis is the most common cause of tooth loss worldwide and a risk factor for atherosclerosis, rheumatoid arthritis, diabetes mellitus, and other diseases. Here we functionally characterize newly discovered gingival solitary chemosensory cells, showing how they detect oral bacteria and act as immune sentinels to protect against periodontitis. Our work provides a promising new approach to treating and preventing periodontitis.

PI_NAMEs: TIZZANO, MARCO  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Adult;Affect;Age;Air;alveolar bone;Alveolar Bone Loss;alveolar destruction;Anti-Bacterial Agents;anti-microbial peptide;Atherosclerosis;Bacteria;Bacterial Infections;bone;bone loss;Cells;chemokine;Cycloheximide;cytokine;Cytoprotection;Dendritic Cells;Diabetes Mellitus;disability;Disease;dysbiosis;Elderly;Elements;Epithelial Attachment;Epithelium;experimental study;Gene Expression;Gingiva;Goals;Grant;Growth;Health;Heterogeneity;Homeostasis;homoserine lactone;Immune;Immunity;Immunohistochemistry;Impairment;In Situ Hybridization;In Vitro;Inflammation;Inflammatory;Innate Immune Response;Knock-out;knockout gene;Knockout Mice;Lactones;Ligands;Liquid substance;Lymphoid Cell;Macrophage;Mediator;Microbe;microbial;microbiome composition;mouse model;Mucous Membrane;Mus;Natural Immunity;novel strategies;Oral;oral bacteria;Oral health;oral microbial community;oral microbiome;pathogen;Pathway interactions;Periodontal Diseases;Periodontitis;Population;prevent;protective effect;quorum sensing;receptor;Receptor Cell;Research;response;Rheumatoid Arthritis;Risk;Risk Factors;Role;Science;selective expression;Sensory;Sentinel;Signal Pathway;Signal Transduction;Signaling Molecule;Systemic disease;Taste Buds;Taste Perception;taste transduction;Testing;Tissues;Tooth Loss;Tooth structure;Topical application;transcriptomics;Wild Type Mouse;Work

PROJECT_TITLE: The role of solitary chemosensory cells in periodontal homeostasis


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: Newark

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Public Health Relevance: Cataract surgery has greatly decreased the burden of blindness worldwide, however, current surgical methods are unable to remove all lens cells, and these undergo a wound healing response post surgery, leading to the formation of scar tissue within the eye, compromising vision. This work will provide fundamental insights into the mechanisms that lead to the inappropriate maintenance of the myofibroblasts that produce scar tissue after cataract surgery. This information will inform the design of strategies to prevent fibrotic posterior capsular opacification, yielding improved visual outcomes for cataract patients.

PI_NAMEs: DUNCAN, MELINDA K (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Anterior;Architecture;Basement membrane;Biology;Blindness;capsule;Cataract;Cataract Extraction;cell behavior;Cell Proliferation;Cell Survival;Cells;Cessation of life;Characteristics;Cicatrix;Communities;Data;Data Set;Deposition;design;Epithelial Cells;Event;Excision;Exposure to;Extracapsular;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Eye;fiber cell;Fibronectins;Fibrosis;Fostering;gene discovery;Gene Expression Profiling;Genetic;Goals;Grant;Growth Factor;Implant;implantation;improved;in vivo;inhibitor;Injury;insight;Integrin alpha5beta1;Integrins;Intraocular lens implant device;lens;lens capsule;Lens Diseases;Lens Fiber;Ligands;Link;Maintenance;Mediating;Mediator;Methods;migration;Modeling;Modern Medicine;Modernization;Molecular;Myofibroblast;Online Systems;Operative Surgical Procedures;Outcome;Pathogenesis;Pathway interactions;Patients;Phenotype;preservation;prevent;Prevention;Process;Production;Proliferating;Protease Inhibitor;protein expression;Proteins;public health relevance;query tools;receptor;Regulation;Reporting;response;response to injury;Role;Signal Transduction;System;Testing;Tissues;tool;transcriptome sequencing;transcriptomics;transdifferentiation;Transforming Growth Factor beta;Up-Regulation;Vision;Visual;Work;wound healing

PROJECT_TITLE: The Influence of Capsule Composition on Lens Biology

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Cortical diseases, including schizophrenia, epilepsy, and stroke, exert a tragic cost on millions of Americans and have a large impact on public health. This project aims to expand our understanding of the physiological underpinnings of cortical receptive fields and their behavioral role by examining the circuit mechanisms that give rise to them. Through cellular-resolution lesions combined with large-scale activity recording via two- photon calcium imaging, this project asks how interactions between groups of similarly and distinctly tuned sensory neurons shape receptive fields and contribute to perception. !

PI_NAMEs: PERON, SIMON  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TITLE: The Role of Local Microcircuits in Shaping Sensory Cortical Activity and Perception

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Clinical Research;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: Project Narrative Parkinson’s disease (PD) often results in widespread motor dysfunction. PD is a progressive and degenerative condition, and thus frequent and granular assessment of motor function is critical to effective management of motor symptoms. In this proposal, we will use an innovative pose estimation approach to enable objective quantification of many motor features of PD using only simple digital videos that can be recorded from common household devices (e.g., smartphones, tablets, laptop computers).

PI_NAMEs: ROEMMICH, RYAN THOMAS (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: 3-Dimensional;Acceleration;Agreement;Algorithms;Artificial Intelligence;Body part;Cellular Phone;Clinic;Clinical;clinical care;clinical decision-making;clinical implementation;clinical movement analysis;Communities;Computer Vision Systems;Computers;cost;Data;Degenerative Disorder;Development;Devices;digital;digital video recording;Dyskinetic syndrome;Emerging Technologies;Equipment;Fingers;Frequencies;Gait;Gait abnormality;Goals;Healthcare;high reward;Home;Household;Human;Impairment;improved;Individual;innovation;instrument;Investments;Joints;kinematics;laptop;Leg;Length;Limb structure;Lower Extremity;Measurement;Measures;Methods;mHealth;mobile application;Motion;Motor;motor control;motor deficit;motor disorder;motor symptom;Movement;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Movement Disorders;Nature;Nerve Degeneration;Neurologist;novel strategies;open source;Parkinson Disease;Pattern;Performance;Persons;Population;Process;Research;Series;Severities;spatiotemporal;Specialist;Speed;System;Tablets;Technology;technology validation;Testing;Time;Toes;tool;Tremor;Underserved Population;Upper Extremity;Video Recording;virtual;Visual;Walking;walking speed;wearable device;Work

PROJECT_TITLE: An automated approach for video-based motor assessment in Parkinson's disease

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Infectious Diseases;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Cryptococcal antigen (CrAg) screening in the blood and preemptive treatment for those who are CrAg positive, prevents the development of cryptococcal meningitis and death; however, 30% of CrAg+ persons die, even with the current standard of care. We propose a phase III randomized trial to evaluate a more potent antifungal, AmBisome, in conjunction with standard fluconazole, to prevent neurologic infection. The findings from this study will impact international HIV treatment guidelines on the optimal management of CrAg+ persons, in order to reduce neurologic disability and mortality in people living with HIV.

PI_NAMEs: RAJASINGHAM, RADHA  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adult;Africa;Africa South of the Sahara;Amphotericin;Amphotericin B;anti-fungal agents;Antifungal Therapy;Antigens;antiretroviral therapy;Blood;brain parenchyma;Cause of Death;CD4 Lymphocyte Count;Cells;Central Nervous System Infections;Cessation of life;Clinical Trials;comparative effectiveness trial;cost;Cost Analysis;cost effective;cost effective intervention;cost-effectiveness evaluation;Country;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;Data;Data Reporting;Development;Disease;Dose;effective therapy;efficacy evaluation;efficacy testing;Enrollment;Excess Mortality;Fluconazole;Flucytosine;Guidelines;high risk;HIV;HIV therapy;Hospital Costs;improved;Incidence;Income;Infection;International;Liposomes;Meningitis;mortality;Neurocognitive;Neurologic;Neurological disability;Neurological outcome;Outcome;Participant;Performance;Persons;Phase;phase III trial;Plasma;prevent;Prevention;Prospective, cohort study;Public Health;Randomized;randomized trial;randomized, clinical trials;Recommendation;recruit;Regimen;safety and feasibility;screening;standard of care;survival outcome;Testing;treatment guidelines;Uganda;Work;World Health Organization

PROJECT_TITLE: Enhanced Antifungal Therapy to Improve Survival in Early Disseminated Cryptococcal Infection


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Home- and community-based services (HCBS) allow older adults, and particularly those with dementia, to remain living at home by supporting health as well as custodial and social needs. Despite widespread use of these services, little is known about the organizations delivering them or how well they are coordinated. Our project will identify and characterize the HCBS organizations that serve those with dementia, and then generate evidence on how well they support coordinated care in order to guide ongoing policy and practice-based efforts to help clinical and social service providers better serve a highly-vulnerable population.

PI_NAMEs: ADLER-MILSTEIN, JULIA ROSE (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Activities of Daily Living;Address;Admission activity;Adult;Aging;Algorithms;Alzheimer's disease related dementia;Area;beneficiary;care coordination;Caregiver Burden;Caring;Characteristics;Client;Clinical;Clinical Services;community based service;Complex;Data;Data Set;Day Care;Dementia;dementia care;density;Diffuse;Dimensions;dual eligible;Emergency department visit;Geography;Health;health care delivery;Health Services;Health system;Healthcare Market;Home;Home Health Aides;hospital readmission;Hospital Referrals;Hospitals;improved;Individual;innovation;Institution;Investigation;Link;Long-Term Care;Measures;Medicaid;Medicaid services;Medical;Medicare claim;Methods;novel;older adult;Outcome;Palliative Care;Patients;Performance;Policies;Population;Provider;Recommendation;Research;Research Personnel;response;Risk;service organization;Services;Skilled Nursing Facilities;skills;social;social service provider;Social Work;Surveys;System;Translating;Vulnerable Populations;Work

PROJECT_TITLE: Advancing Coordination of Home and Community based Services for the ADRD Population

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Neurosciences;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE What are the neural and molecular mechanisms through which psychological stress leads to an inflammatory response, thus increasing risk for cardiovascular disease? The present project will use neuroimaging and pharmacological tools to answer this question, exploring the neural activity patterns and brain network configuration in response to stress that is associated with increases in inflammation, as well as how experimentally blocking one important stress signaling pathway (i.e., beta-adrenergic signaling) shapes neural and inflammatory responses to stress. Ultimately, these studies will fill critical gaps in our knowledge regarding the mechanisms through which stress may lead to cardiovascular disease risk, and help to identify novel targets for future interventions.

PI_NAMEs: MUSCATELL, KEELY ANN (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Acute;Adrenergic Agents;Adrenergic beta-Antagonists;Affective;American;Amygdaloid structure;analytical tool;Anterior;Atherosclerosis;beta-adrenergic receptor;Biological;Biological Assay;Blood specimen;Brain;Brain region;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;Cessation of life;Clinical Trials;computational neuroscience;Computing Methodologies;cytokine;Data;Development;Disease;Dose;Double-Blind Method;double-blind placebo controlled trial;Drug usage;Economic Burden;economic cost;economic impact;Etiology;Event;Functional Magnetic Resonance Imaging;Future;Gene Expression;Goals;Graph;Health;Human;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;innovation;Insula of Reil;Interleukin-6;Intervention;Knowledge;Link;Machine Learning;Maps;Mathematics;Measures;Medial;Mediating;Mediator;Molecular;Network-based;neural;neural circuit;neural patterning;neuroimaging;neuromechanism;novel;Outcome;Pathology;Pathway Analysis;Pathway interactions;Pattern;Pattern Recognition;pharmacologic;Placebo Control;Placebos;Play;preclinical study;prevent;Procedures;Propranolol;Proteins;Psychological Stress;Psychoneuroimmunology;Randomized;Research;response;Risk;Risk Factors;Role;Scanning;Shapes;Signal Pathway;Signal Transduction;social;social genomics;Stress;stress reactivity;stressor;Techniques;Testing;tool;Work

PROJECT_TITLE: Neural and Molecular Mechanisms Underlying Stress-Induced Inflammatory Responses

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Skeletal growth is achieved as growth plate chondrocytes follow a tightly controlled multi-step differentiation process. This project will test the hypothesis that the transcription factors SOX5/6, SOX9 and RUNX2/3 fulfill many of their key functions in these cells in a highly cooperative manner. Verification of this paradigm-shifting hypothesis should deepen understanding of the genetic mechanisms driving skeletogenesis, help uncover the molecular basis of various types of skeletal dysplasias, cartilage tumors and joint degeneration diseases, and illuminate new strategies to prevent and treat these diseases.

PI_NAMEs: LEFEBVRE, VERONIQUE M (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 3-Dimensional;Adolescent;Affect;Automobile Driving;Binding;Biological Assay;Cartilage;Cells;Chondrocytes;chondrodysplasia;Chondrogenic Neoplasm;Chromatin;cofactor;Complex;Data;Degenerative polyarthritis;Disease;DNA Binding;Enhancers;Ensure;Epiphysial cartilage;fetal;Fetus;FGFR3 gene;Genes;Genetic;Genetic Recombination;Genome;genomic profiling;Growth;Heterozygote;human disease;in vivo;Individual;innovation;insight;joint destruction;Knockout Mice;Limb Bud;Maintenance;malformation;Molecular;Mus;mutant;Newborn Infant;novel;Osteoblasts;Pathology;Physiologic Ossification;postnatal development;premature;prevent;Process;programs;promoter;Proteins;psychosocial;recruit;Role;runx proteins;RUNX3 gene;skeletal;skeletal dysplasia;skeletogenesis;Solid;SOX5 gene;SOX6 gene;Structure;synergism;Tertiary Protein Structure;Testing;Tissues;transcription factor;Transcriptional Regulation;transcriptome;tumor;whole genome

PROJECT_TITLE: Transcriptional control of growth plate chondrocytes

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: PROJECT NARRATIVE LMIC: South Africa Institution: Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town Scientific Area: Biostatistics for HIV/AIDS and TB research design and methodology Public Health Relevance: Africa Center for Biostatistical Excellence: Expanding biostatistical leadership for HIV/AIDS and TB research The novel coronavirus disease (COVID-19) poses a growing threat to the progress made towards reducing new HIV infections and care of HIV and Tuberculosis infected people in Sub Saharan Africa. Generation of innovative evidence-informed interventions to address these health problems require well trained methodologists. Leaders in biostatistics provide essential skills in study design, data collection, data analysis and data interpretation, however there is a dearth in biostatistics leadership which need to be addressed.

PI_NAMEs: MACHEKANO, RHODERICK ;YOUNG, TARYN NATALIE (contact)

PROJECT_TERMS: 2019-nCoV;academic program;Address;Africa;Africa South of the Sahara;Area;Biometry;burden of illness;care delivery;Caring;COVID-19;COVID-19 impact;Data;data management;Development;Disease;E-learning;Educational process of instructing;Educational Status;Evaluation;Faculty;Future;Grant;Health;Health Sciences;Healthcare Systems;HIV;HIV/AIDS;Infection;Infrastructure;Institution;International;Lead;Leadership;low and middle-income countries;Medicine;novel;Persons;programs;Research;Research Activity;Research Design;Research Methodology;Research Project Grants;Research Training;response;South Africa;Students;Supervision;Targeted Research;Training;Training Programs;treatment program;Universities;Virus

PROJECT_TITLE: Africa Center for Biostatistical Excellence: Expanding biostatistical leadership for HIV/AIDS and TB Research


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Diabetes;Digestive Diseases;Kidney Disease;Nutrition

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: The STEP-UP program will result in greater participation by under-represented minorities in biomedical research. This participation will benefit society as a whole by bringing unique perspectives to the study of human disease, which often disproportionately affects minorities.

PI_NAMEs: MATTERS, GAIL L.;REEVES, WILLIAM BRIAN (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Address;Affect;African American;Area;Attitude;Award;base;Basic Science;Behavioral;Biomedical Research;career;career development;Cities;Clinical;Clinical Research;Collaborations;college;Communication;Communities;community based research;Competence;Country;data management;design;Diabetes Mellitus;Digestive System Disorders;disabled students;Disadvantaged;disadvantaged background;disadvantaged student;Disease;Disparity population;disparity reduction;Doctor of Philosophy;Educational Curriculum;Endocrinology;Ethnic Origin;experience;Family;Friends;Funding;Future;Goals;hands on research;Health;health care delivery;health care disparity;Health Sciences;Health system;Hematological Disease;higher education;Hispanic Americans;human disease;Infrastructure;inquiry-based learning;interest;Kidney Diseases;Knowledge;Laboratories;Learning;lectures;Life Style;Liver diseases;matriculation;medical schools;Medicine;member;Mentors;Metabolism;mid-career faculty;Minority;Minority Groups;minority student;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Native Americans;nutrition;Obesity;operation;Outcome;Pacific Islander;peer;peer support;Perception;Positioning Attribute;Privacy;programs;Qualifying;Race;recruit;Research;Role;role model;Safety;Science;science teacher;Scientist;Self Efficacy;skills;Societies;student mentoring;student retention;Students;success;symposium;Technical Expertise;Texas;Training;Translational Research;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;Universities;Urologic Diseases;Vocational Guidance

PROJECT_TITLE: Promoting diversity in research careers in diabetes, digestive and kidney diseases


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bipolar Disorder;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Schizophrenia;Serious Mental Illness

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: The single-base-pair resolution maps of DNA (hydroxy)methylation will be generated in sorted inhibitory and excitatory neurons at key time points of postnatal brain development and adulthood, as well as in the brains of psychiatrically normal individuals and patients with schizophrenia and bipolar disorder. The data will be integrated with genetic findings for these disorders as well as with other omics data that have been generated by the PsychEncode Consortium. We anticipate that this work will reveal the molecular and cellular mechanisms and causal relationships of genetic associations, and will suggest specific subtypes of neurons that contribute to disease risk.

PI_NAMEs: MUKAMEL, ERAN A (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Aberrant DNA Methylation;Adolescence;Adult;Affect;Alleles;Attention;Autopsy;base;Base Pairing;Binding Sites;Bipolar Disorder;bisulfite sequencing;Brain;brain cell;Brain region;case control;Cell Nucleus;cell type;Cells;Childhood;Chromosome Mapping;Data;Data Set;demethylation;Development;Disease;disorder risk;DNA;DNA mapping;DNA Methylation;Enhancers;Epigenetic Process;epigenome;epigenomics;Etiology;excitatory neuron;Fluorescence;Functional disorder;gamma-Aminobutyric Acid;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;genetic association;Genetic Risk;Genetic Transcription;genetic variant;Genome;genome wide association study;Glutamates;histone modification;Human;Individual;inhibitory neuron;insertion/deletion mutation;Interneurons;Link;Maps;Measures;Mediating;Mental disorders;Methods;Methylation;methylome;Minor Lymphocyte Stimulatory Loci;Modification;Molecular;neural;Neuroglia;Neurons;neuropsychiatric disorder;Nuclear;Nucleic Acid Regulatory Sequences;Nucleotides;Patients;Population;postmitotic;postnatal;postnatal development;Prefrontal Cortex;Process;progenitor;promoter;Quantitative Trait Loci;recruit;Regulatory Element;Reporting;Resolution;risk variant;Role;Sampling;Schizophrenia;sex;Sex Bias;Site;Sorting;spatiotemporal;Specimen;Techniques;Testing;Time;Tissue Differentiation;Tissues;transcription factor;transcriptome;transcriptome sequencing;Untranslated RNA;Variant;Work

PROJECT_TITLE: 3/3 High-resolution mapping of cell type-specific DNA (hydroxy)methylation in the human brain during postnatal development and in psychiatric disease


ADMINISTERING_IC: EB

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Stanford’s Translational Biomedical Imaging Instrumentation (TBI2) training program is a multidisciplinary predoctoral training program that will train the next generation of researchers and inventors of biomedical imaging technology. Trainees will gain expertise in multiple medical imaging modalities, rigorous and reproducible experimental design, and translational applications. Trainees that complete our training program will have a unique skill set that fullfills a distinct national need for researchers and leaders with expertise in advanced biomedical imaging instrumentation.

PI_NAMEs: BUTTS-PAULY, KIM  (contact);ENNIS, DANIEL B

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TITLE: Stanford's Translational Biomedical Imaging Instrumentation (TBI2) Training Program


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: The proposed research is relevant to public health because it focuses on developing an ultra-long-acting injectable platform for the medication assisted treatment of substance abuse disorder (SUD). Once this platform is developed, there is the promise that a paradigm shifting impact will have been made for patients with SUD, for which current long-acting therapy options are sub-optimal. Thus, the proposed research is relevant to the NIH’s mission and CEBRA that aim to foster highly innovative, high-risk and high impact, and conceptually creative research related to the treatment of SUD.

PI_NAMEs: JOSHI, NITIN  (contact);KARP, JEFFREY MICHAEL

PROGRAM_OFFICER_NAME: LI, FENG

PROJECT_TERMS: acamprosate;biomaterial compatibility;Buprenorphine;Chemicals;clinically relevant;Creativeness;crosslink;Data;density;Development;Diffusion;Disease;Drug Delivery Systems;Drug Exposure;Drug Kinetics;Engineering;evidence base;Excision;Exhibits;FDA approved;Focal Infection;Formulation;Fostering;Goals;high risk;Histologic;Human;hydrophilicity;Hydrophobicity;Image;Implant;improved;In Situ;In Vitro;in vivo;Inflammation;Injectable;innovation;Kinetics;Lamivudine;Liquid substance;Magnetic Resonance Imaging;medication-assisted treatment;Mission;Modeling;Molecular Weight;nalmefene;Naltrexone;Nature;Operative Surgical Procedures;Outcome;particle;Patient Compliance;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;Plasma;polycaprolactone;Polymers;prevent;Process;Public Health;Rattus;Relapse;Research;Risk;Scanning Electron Microscopy;side effect;Solid;Solvents;Structure-Activity Relationship;subcutaneous;Subcutaneous Injections;substance abuse treatment;substance use;Substance Use Disorder;substance use treatment;Tenofovir;Therapeutic;Therapeutic Agents;Time;United States National Institutes of Health;Water

PROJECT_TITLE: Surmounting substance use disorder using an ultra-long acting injectable platform.


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: HEALTH RELEVANCE: Results from the proposed study are expected to provide fundamental knowledge on the role of sensory experience-mediated changes in chromatin and gene expression in flexible behavior. The proposed experiments will identify basic epigenetic, molecular, and circuit principles by which the environment induces changes in gene expression to alter function of individual or ensemble of neurons within a circuit and ultimately modify organismal behaviors. Thus, our findings may lead to novel and cheaper sensory experience-based therapeutic strategies that harness similar types of plasticity against psychiatric disorders, such as autism spectrum disorders, depressive and anxiety disorders, where misprocessing of sensory information accentuates anxiety and social behaviors.

PI_NAMEs: JONES, CORBIN D;VOLKAN, PELIN C (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Affect;Alternative Splicing;Animals;Anxiety;Anxiety Disorders;autism spectrum disorder;Automobile Driving;Behavior;behavior change;Behavior Therapy;Behavioral;Binding;Biological Models;Brain;Calcium;Chromatin;chromatin modification;Chromatin Remodeling Factor;court;Courtship;Cues;Data;Decision Making;Defect;Depressive disorder;Detection;Drosophila melanogaster;Environment;Epigenetic Process;experience;experimental study;Female;fitness;flexibility;fly;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Modified;Genes;Genetic Transcription;Health;Housing;Image;Individual;Insecta;Knowledge;Learning;Link;male;Mammals;Maps;Mediating;men's group;Mental disorders;Modeling;Modification;Molecular;mutant;neural circuit;neuron development;Neurons;neurophysiology;neuropsychiatric disorder;neuroregulation;novel;Organ;Output;Pattern;Peripheral;Pheromone;Pheromone Receptors;programs;promoter;Publishing;Regulation;Regulator Genes;Reporting;response;RNA Splicing;Role;Sensory;sex;Signal Induction;Signal Transduction;Site-Directed Mutagenesis;Smell Perception;social;Social Behavior;Social Environment;Social isolation;Stereotyped Behavior;Stereotyping;Switch Genes;Testing;Therapeutic;Transcript;transcription factor

PROJECT_TITLE: Social experience dependent modification of gene regulation and circuit function

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: PRETORIA

ORG_NAME: SEFAKO MAKGATHO HEALTH SCIENCES UNIVERSITY

PHR: In 2015, the South African National Tuberculosis Programme introduced Bedaquiline (BDQ) to strengthen existing regimens for the therapy of rifampicin-resistant TB. Of great concern, mutations associated with BDQ resistance (rv0678 and atpE) have been identified in Mtb isolated from patients who have never received BDQ or clofazimine (CFZ). In this proposal, we will test our overall hypothesis that mutations in rv0678, atpE and elsewhere in the Mtb genome dysregulate central metabolism which contributes to BDQ and CFZ resistance.

PI_NAMEs: MAKHADO, NDIVHU  (contact);STEYN, ADRIE JC

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Alabama;Bacillus;Bioenergetics;Biological Assay;Carbon;Cause of Death;Clinical;Clinical Investigator;cohort;Collaborations;Country;Data;Drug Efflux;drug metabolism;Drug resistance;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;Drug Targeting;Drug Tolerance;Electron Transport;Energy Metabolism;Excretory function;Exhibits;experimental study;extracellular;Extreme drug resistant tuberculosis;fitness;flexibility;Frequencies;Genes;genome sequencing;Glucose;glyoxylate;Goals;Health;Health Sciences;Healthcare;Homeostasis;improved;Incidence;Infectious Agent;innovation;Intervention;Knowledge;Link;liquid chromatography mass spectrometry;M. tuberculosis genome;Metabolic;Metabolic stress;Metabolism;metabolomics;mortality risk;Multidrug-Resistant Tuberculosis;Mutation;Mycobacterium tuberculosis;new technology;novel;Outcome;Oxygen Consumption;pathogenic microbe;Patients;Persons;Pharmaceutical Preparations;Poison;Predisposition;Prevalence;preventive intervention;Primary Infection;Process;prognostic;programs;prophylactic;Regimen;Regulation;Research;Resistance;Respiration;Rifampicin resistance;Role;Series;Shunt Device;South Africa;South African;stable isotope;Succinates;Technology;Testing;Therapeutic;Therapeutic Intervention;Time;transport inhibitor;Treatment outcome;Tuberculosis;Universities;Variant;Verapamil;whole genome

PROJECT_TITLE: Target and Non-target Based Resistance to Bedaquiline in South Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-W(50)R]


NIH_SPENDING_CATS: Bioengineering;Diabetes;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE. The proposed research seeks to advance and deploy molecular simulation methods that can contribute to the NIH's mission to seek fundamental knowledge to enhance health, lengthen life, and reduce illness and disability. Atomic-resolution simulations will be used to understand the mechanism by which insulin binds to its receptor and itself to enable design of improved insulin therapies for treating diabetes melli- tus. Coarse-grained simulations of cytoskeletal networks will be used to parse the contributions of participating molecular processes to tissue patterning during development, with implications for understanding developmental defects and, more broadly, neuronal synapse formation, wound healing, and tumor growth.

PI_NAMEs: DINNER, AARON  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Actins;Alzheimer's Disease;Amyloid Fibrils;amyloid formation;analog;Anterior;Binding;Biological;Biological Process;Cell Shape;Complement;Computing Methodologies;cost;Coupled;Cytoskeletal Modeling;Cytoskeleton;Defect;design;Development;Developmental Process;Diabetes Mellitus;disability;Disease;Drug Kinetics;Engineering;Equilibrium;Event;experimental study;Feedback;Grain;Health;Immunologics;improved;In Vitro;in vivo;insight;Insulin;Insulin Receptor;Knowledge;Length;Life;mechanical force;Methods;Microscopic;Mission;Modeling;Modification;Molecular;Monomeric GTP-Binding Proteins;Neurodegenerative Disorders;Neurons;pandemic disease;Parkinson Disease;Pattern;Play;Process;Property;Reaction;receptor;receptor binding;Refrigeration;Research;Resolution;RNA-Binding Proteins;Role;self assembly;Signal Transduction;Signaling Molecule;simulation;Specific qualifier value;statistics;Structure;synaptogenesis;Testing;Therapeutic;Therapeutic Index;Time;Tissues;tumor growth;United States National Institutes of Health;wound healing

PROJECT_TITLE: Rare-event simulation and analysis for elucidating mechanisms of development and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative:  In the United States alone, about one million people have Parkinson’s disease and 50-60,000 new cases of PD are diagnosed each year. The causes of PD in most of these cases remain unknown; however, environmental factors have been implicated. The focus of this grant is of two folds: first, to elucidate the mechanisms by which manganese induces neurotoxicity through impaired autophagy and second, to identify potential novel therapeutic targets for PD.

PI_NAMEs: TIEU, KIM  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Address;alpha synuclein;Animals;Autophagocytosis;Bacteria;Brain Diseases;Chemicals;Disease;disease diagnosis;DNA Sequence Alteration;dopaminergic neuron;Dynamin;Environmental Risk Factor;Experimental Models;flexibility;Funding;gene environment interaction;Genetic;Goals;Grant;high standard;Impairment;innovation;Laboratories;Link;Manganese;Mediating;Mitochondria;Modeling;Molecular Target;Mutation;National Institute of Environmental Health Sciences;Neuroglia;Neurons;neurotoxicity;Neurotoxins;new therapeutic target;Paraquat;Parkinson Disease;Pathogenicity;Persons;Play;Predisposition;Proteins;Records;Research Personnel;Research Project Grants;Resources;Role;Stomach;Techniques;Therapeutic;tool;Toxic Environmental Substances;toxicant;United States;Vision;Work

PROJECT_TITLE: Toxicant-induced neurotoxicity mediated by glia-neuron and gene-environment interactions in Parkinson's disease


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Arthritis;Bioengineering;Biotechnology;Osteoarthritis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Boulder

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Treating defects in cartilage and osteochondral tissue remains a formidable clinical problem that eventually leads to osteoarthritis, a debilitating disease. To address this challenge, this project will develop a tissue engineering solution that utilizes bioinspired 3D printing and biomimetic hydrogels to guide stem cell differentiation, promote tissue regeneration and support integrative repair, while protecting the surrounding tissue from further degeneration.

PI_NAMEs: BRYANT, STEPHANIE J (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: 3D Print;Address;analog;Animal Model;Animals;articular cartilage;Biochemical;Biomimetics;Bioreactors;bone;Bone Tissue;Cartilage;cell motility;Cell Separation;Cells;Cementation;Chondrocytes;Clinical;clinical translation;Computer Models;Cues;Defect;Degenerative polyarthritis;design;Development;Disease;DsRed;effectiveness evaluation;Engineering;Environment;Extracellular Matrix;Family suidae;Finite Element Analysis;Funding;Goals;Growth Factor;healing;Health;Human;Hydrogels;implantation;In Situ;In Vitro;in vivo;in vivo Model;in vivo monitoring;in vivo regeneration;Inferior;Joints;Label;Lesion;Link;Longitudinal Studies;MAPK3 gene;MAPK8 gene;Measurement;mechanical properties;Mechanics;mechanotransduction;Mesenchymal Stem Cells;mimetics;Mitogen-Activated Protein Kinases;Modeling;Monitor;Multiscale Mechanics;Natural regeneration;Nutrient;Osteoblasts;osteochondral tissue;p38 Mitogen Activated Protein Kinase;Pathway interactions;Phenotype;Physiological;pre-clinical;Property;Rattus;regenerative;regenerative approach;regenerative therapy;regenerative tissue;repaired;Signal Pathway;Signal Transduction;stem cell differentiation;stem cell fate;stem cells;Structure;subchondral bone;Surface;Techniques;Testing;time use;Tissue Engineering;tissue regeneration;tissue repair;Tissues;transcriptome sequencing;Translating;Translational Research;Translations;Weight-Bearing state

PROJECT_TITLE: Bioinspired Mechanically Stiff Hydrogels for Osteochondral Tissue Regeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: CORAL GABLES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative Patients with end-stage renal disease require the creation of a vascular access to secure hemodialysis and save their life. This study aims at identifying pathogenic molecules responsible for the failure of the most common vascular access, the arteriovenous fistula. Outcomes from these studies may represent a breakthrough that will provide new therapeutic targets and strategies to improve vascular access dysfunction, reduce medical complications and ultimately, prolong these patient's lives.

PI_NAMEs: VAZQUEZ PADRON, ROBERTO IRENARDO (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Age;American;Arteriovenous fistula;Automobile Driving;Basic Science;biobank;Biology;Blood flow;Blood Vessels;Catheters;cell type;Chronic Kidney Failure;Clinical;cohort;cost comparison;Data;design;Development;Dialysis patients;Dialysis procedure;Ectopic Expression;End stage renal failure;experience;Experimental Animal Model;Failure;Fibrosis;Fistula;Functional disorder;Gene Expression;Genetic;Genetic Transcription;Goals;Hemodialysis;Human;Hyperplasia;improved;Inflammation;Inflammatory;inhibitor;Injections;Intervention;Kidney Diseases;Knockout Mice;Lead;Legal patent;Leukocyte L1 Antigen Complex;Life;Mediating;Medical Care Costs;medical complication;Microsurgery;Molecular;Morbidity - disease rate;mortality;Mus;Nephrectomy;new therapeutic target;novel therapeutics;Outcome;Outcome Study;Pathogenicity;Pathologic;Patient Selection;Patients;Phenotype;Postoperative Period;prevent;proto-oncogene protein Spi-1;Publishing;Quality of life;Random Allocation;Research;response;Retrospective cohort;Risk;Role;Sampling;Secure;sex;Signal Transduction;Smooth Muscle Myocytes;SPI1 gene;Stenosis;Stromal Cell-Derived Factor 1;Study models;systemic inflammatory response;Tamoxifen;targeted treatment;Techniques;Testing;Translational Research;Up-Regulation;Validation;Venous

PROJECT_TITLE: The Role of Vascular Calprotectin in Arteriovenous Fistula Maturation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-W(05)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Headaches;Migraine;Neurosciences;Pain Research;Pediatric;Telehealth

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Narrative The purpose of this study is to test the efficacy of the “Migraine Manager” portal recently developed to promote better self-management in adolescent patients with migraine and their families using evidence-based assessment and intervention. We will evaluate the effect of Migraine Manager on headache frequency, health- related quality of life, and migraine-related disability compared to an attention control group in a single site randomized controlled trial. Positive results of this trial will have a significant impact on the migraine population by providing an efficacious clinical tool that can be disseminated and implemented broadly to underserved adolescents with migraine, who would not otherwise receive evidence-based self-management support.

PI_NAMEs: HOMMEL, KEVIN  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Address;Adherence;Adolescent;adolescent patient;Adult;Advanced Practice Nurse;Affect;Aftercare;Age Years;Algorithms;arm;attentional control;Behavior;behavior change;Behavior Therapy;Behavioral;Belief;biobehavior;Biometry;Caregivers;Caring;Child;Childhood;Chronic;Clinic;Clinic Visits;Clinical;clinical effect;Clinical Trials;Cognitive Therapy;Collaborations;Computers;Control Groups;cost;Data;Development;digital treatment;disability;Disease;Eating;economic impact;Education;Effectiveness;efficacy evaluation;efficacy testing;Ensure;evidence base;Exercise;experience;Family;feasibility trial;follow up assessment;follow-up;forgetting;Frequencies;Funding;good diet;Habits;handheld mobile device;Headache;Health;Health Care Costs;health care disparity;health related quality of life;Health Services Accessibility;Healthcare;Home;Hydration status;improved;Internet;Intervention;Intervention Studies;Life Style;Life Style Modification;medication nonadherence;Migraine;Migraine disability;migraine treatment;Modeling;Monitor;Morbidity - disease rate;neglect;Nurses;Opioid;Outcome;Pain management;Parents;Participant;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Physical Function;pilot test;pilot trial;poor health outcome;Population;primary endpoint;Public Health;Qualifying;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;Recommendation;recruit;relapse risk;Reporting;Research;Resources;Self Management;Site;skills;Sleep;Social Functioning;symptom management;Symptoms;Testing;Time;tool;Training;treatment effect;Treatment Efficacy;treatment planning;Visit

PROJECT_TITLE: Randomized Controlled Trial of Migraine Manager: A Digital Therapeutic Self-Management Tool for Adolescents with Migraine

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Four highly homologous genes of the SLO family encode potassium channel pore-forming subunits that are broadly expressed among tissues, share the feature that they are regulated by dynamic changes in specific cytosolic ion concentrations, and broadly influence function and electrical excitability in cells in which they are found. Rich diversity in function of such channels arises from tissue-specific expression of two families of auxiliary subunits ( and ), which in some cases have been implicated in various pathologies linked to specific SLO family channels, such as hypertension and epilepsy. Using methods of electrophysiology coupled with genetic manipulations that delete specific subunits from mice, this project is a long-term effort to define the functional properties conferred on SLO family channels by their auxiliary subunits, how channels of a specific subunit composition impact on cellular physiology, and whether such channels may underlie any pathological changes in cell physiology.

PI_NAMEs: LINGLE, CHRISTOPHER J (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Action Potentials;Address;Animal Model;animal model development;Behavior;Binding Sites;biophysical analysis;Biophysics;Calcium;Cell Physiology;Cells;Colon;Coupled;Electrophysiology (science);Epilepsy;Epithelial Cells;Epithelium;Evaluation;Family;Family member;fascinate;Feedback;Future;Genes;Genetic;genetic manipulation;Homologous Gene;Hypertension;Inner Hair Cells;insight;Ion Channel;Ions;Knock-out;Laboratories;large-conductance calcium-activated potassium channels;Link;Methods;Modeling;Mus;Pathologic;Pathology;Physiological;Physiology;Play;Potassium Channel;Property;Regulation;Role;stoichiometry;Stroke;therapeutic target;Tissues;tumor growth;voltage;Work

PROJECT_TITLE: SLO family potassium channels: function and physiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PI_NAMEs: DRACHEVA, STELLA  (contact)

PROJECT_TITLE: 2/3 High-resolution mapping of cell type-specific DNA (hydroxy)methylation in the human brain during postnatal development and in psychiatric disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Depression;Lewy Body Dementia;Mental Health;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE There is little guidance to help people with dementia with Lewy bodies (DLB) and their caregivers know when the person with DLB is approaching the end of life. This study will identify factors that predict the end of life in DLB and factors that affect quality end of life care. The information gained by this study will (1) help physicians, people with DLB, and caregivers better plan for the future by knowing what to expect and (2) identify areas where care can be changed to improve end of life experiences.

PI_NAMEs: ARMSTRONG, MELISSA JO (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Area;aspirate;Behavioral;Behavioral Symptoms;Bereavement;Caregiver Burden;caregiver quality of life;Caregiver well-being;Caregivers;Caring;Centers of Research Excellence;Cessation of life;Characteristics;Child;Clinical;Cognitive;cohort;Cohort Studies;Collaborations;comorbidity;coping;Counseling;Data;Data Set;Databases;decubitus ulcer;Dementia;Dementia with Lewy Bodies;Demographic Impact;demographics;end of life;end of life care;Enrollment;evidence base;experience;Face;Failure to Thrive;Family;Future;Grief reaction;Guidelines;Hallucinations;Health Personnel;Healthcare;Home;hospice environment;improved;Individual;informal caregiver;Intervention;Knowledge;Lewy Body Dementia;Life;Life Experience;Location;Longitudinal cohort study;Measures;Medical;medical specialties;Medicare;Mental Depression;Modeling;Motor;Movement Disorder Society Unified Parkinson's Disease Rating Scale;National Institute on Aging;neurodegenerative dementia;novel;nursing skill;Outcome;Patients;Persons;Physicians;Pneumonia;Population;Predictive Factor;predictive tools;Provider;Publishing;Quality of Care;Quality of life;Recovery;recruit;Reporting;residence;resilience;Rural;satisfaction;Self Efficacy;Series;Severities;Signal Transduction;Sleep;Social support;Specialist;Spouses;suburb;Symptoms;Telephone;tool;United States;virtual;virtual group;Visit

PROJECT_TITLE: Identifying Factors Predicting ACcurately End-of-Life in Dementia with Lewy Bodies and Promoting Quality End-of-Life Experiences: the PACE-DLB Study

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: CITY OF INDUSTRY

ORG_NAME: PUBLIC HEALTH FOUNDATION ENTERPRISES

PHR: PROJECT NARRATIVE SHARP (Summer HIV/AIDS Research Program) is an innovative and highly-applied HIV and substance use summer research experience for undergraduates who are underrepresented in science and medicine. SHARP scholars engage in research under the mentorship of leading HIV investigators, engage in peer-to-peer support, didactics, workshops and lectures, and have opportunities to shadow and participate in community events and other learning experiences designed to inspire them to pursue further studies and careers in public health-oriented clinical, socio-behavioral, and community-focused research. SHARP is a pathway program that aims to train the next generation of scientists.

PI_NAMEs: FUCHS, JONATHAN D. (contact);SAUCEDA, JOHN ANDREW

PROGRAM_OFFICER_NAME: FRIEND, LINDSEY NICOLE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;antiretroviral therapy;Applied Research;Area;Award;Behavior Therapy;Behavioral;burden of illness;California;career;career networking;Caring;catalyst;Cessation of life;Cities;Clinical;Clinical Research;Cognitive;cohort;college;Color;Communities;community college;Country;Curiosities;Dedications;design;digital;Disease Progression;Disparity;E-learning;Educational workshop;Enrollment;Environment;Epidemic;Epidemiology;Equilibrium;Equity;Ethnic Origin;Event;experience;Extramural Activities;Faculty;Fortune;Fostering;Funding;Future;graduate school;Health;Historically Black Colleges and Universities;HIV;HIV disparities;HIV Infections;HIV/AIDS;Incidence;Infection;Infrastructure;innovation;insight;Institution;interest;Intervention;Investments;Learning;lectures;Link;Manuscripts;medical schools;Medicine;men of color;men who have sex with men;Mentors;Mentorship;Methods;microbicide;Minority Health Research;minority investigator;minority trainee;Minority-Serving Institution;Modeling;Morbidity - disease rate;mortality;Municipalities;National Institute of Drug Abuse;next generation;novel;Online Systems;Outcome;outreach;Pathway interactions;peer;peer coaching;peer networks;Peer Review;peer support;Pharmacologic Substance;Politics;poor health outcome;pre-exposure prophylaxis;Preventive vaccine;programs;Public Health;public health research;Public Speaking;Race;Recommendation;recruit;Reproducibility;Research;Research Design;research faculty;Research Methodology;Research Personnel;Research Project Grants;responsible research conduct;Risk;Risk Factors;role model;San Francisco;Scholars Program;Science;Scientist;Secure;self-directed learning;skills;social;Social Behavior;social health determinants;Social Network;STEM field;Structure;substance use;success;summer internship;summer program;summer research;Supervision;symposium;System;Talents;Testing;theories;Time;Training;Training Programs;transgender women;Translational Research;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;university student;Vision;Vulnerable Populations;webinar;Work;Writing

PROJECT_TITLE: The Summer HIV/AIDS Research Program (SHARP)


NIH_SPENDING_CATS: Genetics

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE Our work will facilitate identification of appropriate biomarkers for determining risk of developing cancer through environmental exposures, advance the design of more effective chemotherapeutic drugs that are less susceptible to loss of efficacy due to repair, and yield a predictive tool to identify mutational hotspot sequences induced by different environmental lesions in human tumors.

PI_NAMEs: BROYDE, SUSE  (contact)

PROGRAM_OFFICER_NAME: HEACOCK, MICHELLE

PROJECT_TERMS: Acetylation;Address;adduct;Affect;Air;Airborne Particulate Matter;Antineoplastic Agents;Aromatic Compounds;Aromatic Polycyclic Hydrocarbons;base;Base Sequence;Binding;Biological Markers;Bypass;carcinogenicity;Characteristics;Chemical Structure;Chemicals;chemotherapy;Complement;crosslink;Cryoelectron Microscopy;Cytosine;design;Disease;DNA;DNA Damage;DNA lesion;DNA Sequence;DNA-Directed DNA Polymerase;DNA-protein crosslink;Environmental Exposure;Environmental Pollutants;Excision;exhaust;experimental study;Failure;Food;Fossil Fuels;Free Energy;frontier;gene repair;Genomics;genotoxicity;Guanine;helicase;Histone Acetylation;Homologous Gene;Human;human disease;Human Genome;Impairment;Induced Mutation;insight;interest;Lesion;Malignant Neoplasms;Methods;Modeling;Modification;Molecular;Molecular Conformation;molecular dynamics;Mutagenesis;mutant;Mutation;Nature;Nucleosomes;Nucleotide Excision Repair;Orthologous Gene;Outcome;Pathologic Mutagenesis;Peptides;Pharmaceutical Preparations;Pharmacotherapy;Play;Polymerase;Positioning Attribute;predictive tools;Predisposition;Process;Productivity;Property;Proteins;Reactive Oxygen Species;repaired;Resistance;Ribonucleotides;Risk;Shapes;Site;sound;Source;stereochemistry;Structure;superfund site;Testing;Therapeutic;Thermodynamics;Tobacco smoke;transcription factor TFIIH;tumor;Ultraviolet Rays;wasting;Water;Work;Xeroderma Pigmentosum;Yeasts

PROJECT_TITLE: Environmental DNA Lesions and Mutagenesis: Molecular Mechanisms of Lesion Recognition for Repair and Polymerase Bypass

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: A new medical imaging camera that provides superior performance than existing cameras will be developed and evaluated in this project. The camera will be made available to the cancer research community and will accelerate development, growth and clinical translation of new promising emerging cancer therapy methods. It will also lead to technology advancement that will enable research community and industry in developing next generation clinical imaging instrumentations.

PI_NAMEs: DU, YONG  (contact);GHALY, MICHAEL ;MENG, LING-JIAN

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: 3-Dimensional;Academia;Acceleration;Actinium;Alpha Particles;animal imaging;Animals;anti-cancer research;Area;Behavior;Biological Response Modifier Therapy;Canada;cancer cell;cancer therapy;Canis familiaris;Characteristics;Clinical;clinical imaging;Clinical Research;clinical translation;Clinical Trials;Collaborations;Communities;Complex;compound eye;Custom;Data;Daughter;DCNU;design;Detection;detection platform;detector;Development;Diagnostic;Discipline of Nuclear Medicine;Distributional Activity;Dose;dosimetry;Engineering;Ensure;experience;External Beam Radiation Therapy;Family suidae;flexibility;Gamma Cameras;Gamma Rays;Generations;Goals;Growth;Image;image reconstruction;imaging capabilities;imaging detector;imaging study;imaging system;improved;in vivo;Industry;Industry Collaboration;instrumentation;Interdisciplinary Study;Isotopes;Knowledge;Letters;Linear Energy Transfer;manufacture;Manufacturer;Marketing;Measures;Medical Imaging;Memorial Sloan-Kettering Cancer Center;Methods;Modality;Monkeys;Neoplasm Metastasis;next generation;novel;Online Systems;Organ;Oryctolagus cuniculus;Parents;Pathway interactions;Patient Selection;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Photons;Physics;Polishes;pre-clinical;Predisposition;Radioisotopes;Radionuclide Imaging;Radionuclide therapy;Radiopharmaceuticals;reconstruction;Research;Research Personnel;Resistance development;Resolution;response;Roentgen Rays;Services;single photon emission computed tomography;success;System;Systemic disease;targeted imaging;Techniques;Technology;technology development;Therapeutic;Tissue imaging;Toxic effect;tumor;Universities;web based interface;Work

PROJECT_TITLE: Hyperspectral Single Photon Imaging of Targeted Alpha-Emitters


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Childhood Leukemia;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Neurosciences;Patient Safety;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The proposed research leverages the REDIAL Consortium infrastructure to better understand the drivers of disparities in a debilitating side effect of methotrexate chemotherapy. Specifically, this study will integrate patient- reported outcome, metabolomic, genomic, and advanced neuroimaging data to identify novel biomarkers of clinical methotrexate neurotoxicity in pediatric ALL patients. This research has significant translational potential and may inform the delivery of targeted interventions to high-risk patients, with the goal of reducing unnecessary morbidity and improving outcomes.

PI_NAMEs: BROWN, AUSTIN L (contact);MEODED, AVNER

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: Acute;Acute leukemia;Acute Lymphocytic Leukemia;Address;Adolescent;Affect;Antimetabolites;Aphasia;Biological;Biological Markers;biomarker identification;cancer diagnosis;Central Nervous System;Cerebrospinal Fluid;Characteristics;chemotherapy;Child;Childhood;Childhood Acute Lymphocytic Leukemia;Clinical;Clinical Data;clinical development;Clinical Management;clinical risk;cohort;comparative;Complex;curative treatments;Data;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;Disparity;disparity reduction;Distress;Dose;Dose Limiting;Encephalopathies;Epidemiology;ethnic disparity;ethnic diversity;Ethnic Origin;Ethnic Population;Etiology;evidence base;experience;Fatigue;Functional disorder;Future;genetic variant;Genetic Variation;Genomics;Genotype;Goals;Headache;high risk;improved;improved outcome;Incidence;Inferior;Infrastructure;Inherited;innovation;insight;Institution;Integration Host Factors;Intervention;Investigation;Latino;Latino Population;Leukemia Acute Lymphoblastic Chemotherapy;leukemia relapse;leukemia treatment;Magnetic Resonance Imaging;metabolomics;Methotrexate;Molecular;Morbidity - disease rate;multi-ethnic;multiple omics;Nervous System Trauma;neural network;Neuroanatomy;neuroimaging;neuroimaging marker;Neurologic Symptoms;neurotoxicity;Newly Diagnosed;novel;novel marker;Outcome;Pain;painful neuropathy;Participant;Pathway interactions;Patient Outcomes Assessments;patient stratification;Patients;pediatric acute leukemia;Pediatric cohort;pediatric patients;Pharmacogenomics;Pharmacometabolomics;Phenotype;preclinical toxicity;Predictive Factor;prevent;Prevention strategy;Process;prospective;Prospective cohort;Quality of life;Quantitative Trait Loci;Relapse;relapse risk;remediation;Reporting;Research;Resources;response;Risk;risk stratification;Sampling;Schedule;screening;Seizures;side effect;Survival Rate;Symptoms;System;targeted delivery;Techniques;therapeutic target;Toxic effect;tractography;translational potential;treatment disparity;Treatment Efficacy;Treatment-related toxicity;white matter

PROJECT_TITLE: A Systems Epidemiology Approach for Predicting Methotrexate Neurotoxicity in Pediatric Acute Leukemia

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Kidney Disease

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Immune checkpoint inhibitors (ICIs) are immunotherapies increasingly used in patients with wide varieties of cancers; however, they can also cause autoimmune toxicities affecting multiple organ systems, including the kidney. Currently, the pathogenesis of ICI-induced kidney injury is not well-understood, and epidemiologic studies suggest a high fraction of ICI-treated patients develop clinically-significant decline in kidney function over time. Using single-cell genomics and longitudinal biomarker studies, this proposal seeks to identify pathways that can help understand how acute and chronic kidney disease develops after ICIs to ultimately lead to novel diagnostic and therapeutic strategies to prevent kidney disease.

PI_NAMEs: SISE, MEGHAN E. (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute;Adaptive Immune System;Address;adjudication;Affect;Albuminuria;Antitumor Response;autoimmune toxicity;Automobile Driving;Benchmarking;biobank;Biological;Biological Markers;biomarker identification;Biopsy;Blood;Body System;cancer care;cancer cell;Cancer Center;Cancer Patient;cancer therapy;cancer type;Caring;Cell Physiology;cell type;Cells;checkpoint therapy;Chronic;Chronic Kidney Failure;Clinical;clinically significant;cohort;comparison control;cytokine;Cytotoxic T-Lymphocytes;Development;Diagnosis;Disinhibition;Eligibility Determination;Enrollment;epidemiology study;Excision;Exhibits;experience;Future;Gene Expression Profiling;General Hospitals;Genetic Transcription;Glomerular Filtration Rate;Goals;Healthcare Systems;hemodynamics;high risk population;Immune;Immune checkpoint inhibitor;immune-related adverse events;Immunotherapy;Inflammatory;Infrastructure;inhibiting antibody;Injury;Injury to Kidney;innovation;insight;Interleukin-6;Interstitial Nephritis;Intervention Studies;Kidney;kidney biopsy;Kidney Diseases;Lymphocytic Infiltrate;Malignant Neoplasms;Massachusetts;Measures;Mediating;Melanoma;member;Molecular;Monoclonal Antibodies;multidisciplinary;noninvasive diagnosis;novel diagnostics;novel therapeutic intervention;Oncologist;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Population;Positioning Attribute;prevent;Principal Investigator;programs;prospective;protein biomarkers;Publishing;recruit;Renal function;Research Design;Research Personnel;Research Project Grants;Role;Services;side effect;single cell genomics;single-cell RNA sequencing;Specimen;Survivors;T cell receptor repertoire sequencing;T cell response;T-Cell Receptor;T-Lymphocyte;Technology;therapy design;Time;Tissues;TNF gene;Toxic effect;translational research program;Urine;Work

PROJECT_TITLE: Mechanisms driving acute and chronic kidney function decline after immune checkpoint inhibitor therapy for cancer

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Brain Disorders;Genetic Testing;Genetics;Infant Mortality;Mucopolysaccharidoses (MPS);Neurodegenerative;Orphan Drug;Pediatric;Prevention;Rare Diseases

ORG_CITY: AMHERST

ORG_DEPT: NEUROLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE Newborn screening has immense benefits for babies with genetic diseases; however, some newborn screening tests have inherent inaccuracies that can cause delays in treatment or can subject some babies to unnecessary therapies. Improving diagnostic tools for the three genetic disorders targeted by this grant (Krabbe Disease, Pompe Disease and Mucopolysaccharidosis type I) will ensure that newborn babies who will benefit from treatment for these disorders will receive it promptly, and that the health of infants who do not require intervention will not be jeopardized by potentially dangerous treatments.

PI_NAMEs: LANGAN, THOMAS J (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: acronyms;Address;Alpha-glucosidase;Anxiety;Area;Assessment tool;Biological Markers;Blood;Blood Screening;Chicago;Childhood;Clinical;Collaborations;Collection;Creatine;Dangerousness;Data;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic screening;diagnostic tool;Disease;Dryness;Early treatment;Eligibility Determination;Enrollment;Ensure;Enzymes;experimental study;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;follow-up;galactosylceramidase;Genetic;Genetic Diseases;Genotype;Globoid cell leukodystrophy;Glycogen storage disease type II;Glycosaminoglycans;Goals;Grant;Guidelines;high risk;Illinois;improved;Infant;Infant Health;infant monitoring;Intervention;Japan;L-Iduronidase;Life;Measures;metropolitan;Missouri;Morbidity - disease rate;mortality;Mucopolysaccharidoses;Mucopolysaccharidosis I;Neonatal Screening;New York;Newborn Infant;novel;novel diagnostics;Ohio;Parents;Pilot Projects;predictive tools;Predictive Value;prevent;programs;prospective;prospective test;Psychosine;Reporting;Retrospective Studies;Risk;screening;Screening procedure;screening program;Screening Result;Site;Source;Spottings;Stress;Symptoms;Testing;Time;tool;Translational Research;Treatment Efficacy;Treatment outcome;Uncertainty;United States;unnecessary treatment;virtual;virtual repository;Work

PROJECT_TITLE: Enhancement of Newborn Screening Diagnostic Paradigms to Improve the Efficacy of Treatment for Krabbe Disease, Pompe Disease, and Mucopolysaccharidosis Type 1

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: Los Angeles

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: The only known cure of an HIV-infected individual was the result of an allogeneic stem cell transplantation, for leukemia, using cells from a donor carrying the CCR5∆32 mutation. To translate this to a treatment appropriate for patients without cancer we are combining advances in stem cell engineering with novel approaches to transplantation. Our goal is to recapitulate the elements of this cure without the unacceptable side-effects of the cancer treatment.

PI_NAMEs: CANNON, PAULA M (contact);KIEM, HANS-PETER

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Allogenic;Animal Model;Antibody-drug conjugates;antiretroviral therapy;arm;Autologous;Behavior Therapy;Berlin;Biomimetics;Biotechnology;Bone Marrow;cancer therapy;CCR5 gene;Cell Compartmentation;cell regeneration;Cell Transplantation;Cells;chimeric antigen receptor T cells;Clinical;combinatorial;Combined Modality Therapy;Communicable Diseases;comparative efficacy;conditioning;cryogel;Data;Defect;Defense Mechanisms;DNA;DNA Repair;Dose;Educational process of instructing;Elements;Engineered Gene;engineered stem cells;engineered T cells;Engineering;Engraftment;Environment;Frequencies;gain of function mutation;Gene Combinations;gene therapy;gene-editing approach;Genes;Genetic Engineering;genome editing;Goals;graft vs host disease;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;HIV;HIV Infections;HIV resistance;HIV Seropositivity;HIV/AIDS;Human;humanized mouse;Immune;immune reconstitution;Immune response;Immunity;Immunoglobulin G;immunoreaction;Immunotherapy;improved;Individual;Infection;inhibitor;leukemia;Lymphoma;Macaca;Malignant Neoplasms;Mediating;Methods;Modeling;mouse model;Mutation;nanobodies;neutralizing antibody;Nonhomologous DNA End Joining;nonhuman primate;novel;novel strategies;Outcome;Pathway interactions;Patients;Population;post-transplant;preservation;Production;programs;Property;Protocols documentation;Regimen;repaired;Research Personnel;Resistance;Rosaniline Dyes;Safety;Series;side effect;simian human immunodeficiency virus;Site;Stem cell transplant;T cell reconstitution;T cell response;T-Cell Development;T-Lymphocyte;targeted nucleases;Technology;Testing;Therapeutic;Therapeutic immunosuppression;Toxic effect;Translating;Transplantation;Viral;Work

PROJECT_TITLE: Novel hematopoietic stem cell engineering and transplantation approaches for HIV cure


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: The Administrative Core will coordinate the administrative, fiscal, and organizational aspects of this U19 program. As a complex and highly interactive program involving different institutions, the Core will be an essential component of the U19 Program.

PI_NAMEs: CANNON, PAULA M (contact)

PROJECT_TERMS: Cell Transplantation;Collaborations;Communication;Complex;Data;data dissemination;engineered stem cells;Ensure;Goals;Hematopoietic stem cells;HIV;humanized mouse;Institution;Investigation;Joints;Leadership;Modeling;nonhuman primate;novel;Principal Investigator;Procedures;programs;Research Personnel;success;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: NARRATIVE  The goal of this predoctoral training program is to train the next generation of researchers in microbiology and pathogenesis to prepare them with the skills necessary to address the nation’s critical needs in the battle against infectious disease. To do so, this program takes a student-centric, autonomy-supportive approach with the goal of training self-motivated, independent research scientists, who are well prepared for diverse research career paths.

PI_NAMEs: DUNMAN, PAUL M. (contact);WARD, BRIAN M

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Infection and Immunity: The Pathogenesis of Host-Microbe Interactions

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: PROJECT NARRATIVE Despite the success of combination antiretroviral therapy (ART), HIV-1 remains a substantial public health burden. Our consortium will optimize targeted methods to modify and enhance HIV-specific immunity, and implement these approaches in a manner that can be safely and feasibly applied for all persons living with HIV. The role of the NHP core is to support preclinical modeling studies associated with each project in our consortium, and to direct our findings towards future studies in ART-suppressed HIV+ patients.

PI_NAMEs: KIEM, HANS-PETER  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Alleles;Animals;antiretroviral therapy;Autologous;Bar Codes;Berlin;Biological Assay;Bone Marrow;California;Caring;Case Study;CCR5 gene;Cell Transplantation;Cells;Clinical Research;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Communicable Diseases;conditioning;Control Animal;cryogel;Data;Dedications;design;Development;Disease remission;Dose;efficacy evaluation;emtricitabine;engineered stem cells;Engraftment;experience;Experimental Designs;Fumarates;Future;gene function;Gene Modified;gene therapy;gene-editing approach;Genes;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;HIV;HIV Infections;HIV-1;Immunity;improved;in vivo;in vivo engraftment;Individual;Infection;Kinetics;latent infection;Letters;London;Louisiana;Macaca mulatta;Malignant Neoplasms;manufacture;Measures;Methods;model development;Modeling;Modification;nonhuman primate;novel;novel strategies;Oregon;Patients;peripheral blood;Persons;Phase;pinacolyl methylphosphonic acid;Plasma;Play;Population;Positioning Attribute;post-transplant;Pre-Clinical Model;Primates;Prior Therapy;Prodrugs;Protocols documentation;Public Health;Publishing;Recovery;Rectum;Regimen;repaired;Research;Research Design;Research Personnel;Role;Rosaniline Dyes;Safety;Sampling;simian human immunodeficiency virus;Source;stem cell genes;Stem cell transplant;Study models;success;Supportive care;synergism;Tenofovir;Therapeutic;Tissues;translational medicine;Transplantation;Vaccine Therapy;Viral Load result;viral rebound;Viral reservoir;Virus;Virus Replication;Washington;Work

PROJECT_TITLE: Primate Core