ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Cerebrovascular;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Obesity;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE The proposed research continues the successful stroke surveillance over 7 decades of follow up in the Framingham Heart Study (FHS) cohorts and expands the research program to study post-stroke vascular cognitive impairment and dementia (PS-VCID), a critical public health challenge that contributes to nearly one third of Alzheimer’s disease and related dementias. The investigators seek to leverage FHS resources towards a better understanding of PS-VCID trends and determinants, to study the causal relations of obesity and dyslipidemia with PS-VCID, to explore repurposing of available drug treatments. We will collaborate with the REGARDS and ARIC studies for development and validation of novel PS-VCID risk prediction tools, incorporating genetic, imaging, social and clinical data, for application in clinical practice and research.

PI_NAMEs: APARICIO, HUGO JAVIER;ROMERO, JOSE RAFAEL (contact);SESHADRI, SUDHA

PROGRAM_OFFICER_NAME: HOMMER, REBECCA EVE

PROJECT_TERMS: Acute;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Atherosclerosis Risk in Communities;Atrial Fibrillation;biracial;Black Populations;Black race;Blood Vessels;Body mass index;brain health;Brain imaging;burden of illness;cardiovascular risk factor;Cardiovascular system;Categories;Central obesity;Cerebral small vessel disease;cerebrovascular;Characteristics;Clinical;Clinical Data;clinical practice;Clinical Research;clinical risk;Cognitive deficits;cognitive performance;cohort;Cohort Studies;Collaborations;Communities;comorbidity;Complex;Data;Dementia;dementia risk;deprivation;Development;Diabetes Mellitus;disability;Disease;drug repurposing;Drug Targeting;Dyslipidemias;Education;Educational Status;Epidemic;Epidemiology;Exposure to;follow-up;Framingham Heart Study;Gene Expression;Gene Proteins;Genes;Genetic;Genetic Determinism;Genetic Risk;Genomics;Goals;gray matter;high dimensionality;Hypertension;Image;Impaired cognition;improved;Incidence;indexing;Individual;Injury;Knowledge;Lesion;Life;Life Cycle Stages;life span;Life Style;lifetime risk;Link;Lipids;Location;Machine Learning;machine learning method;Measures;Mendelian randomization;method development;Methods;Modeling;multimodal data;Multiomic Data;National Institute of Neurological Disorders and Stroke;neighborhood disadvantage;neuroimaging;Neuropsychological Tests;novel;Obesity;Organ;Participant;Pathway interactions;Pattern;personalized intervention;Pharmaceutical Preparations;Pharmacotherapy;polygenic risk score;Population;post stroke;post stroke cognitive impairment;Predictive Factor;predictive modeling;predictive tools;Prevalence;prevent;Prevention;Prevention strategy;Prevention trial;primary outcome;Prognosis;programs;prospective;Proteomics;Public Health;public health intervention;racial population;Reasons for Geographic And Racial Differences in Stroke;Recurrence;Research;Research Personnel;Research Priority;resilience;Resources;Risk;Risk Assessment;Risk Factors;Risk Marker;risk prediction;risk prediction model;Role;Sampling;Secondary to;Severities;sex;social;social determinants;social factors;social health determinants;Stroke;stroke cognitive outcome;stroke incidence;stroke risk;stroke survivor;Surveillance Program;Survivors;Thick;Time;tool;transcriptomics;Treatment Factor;trend;Validation;vascular cognitive impairment and dementia;vascular risk factor;Work

PROJECT_TITLE: Precursors of Stroke Incidence and Prognosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-G(02)M]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PI_NAMEs: RIVERS, BRIAN M. (contact)

PROJECT_TERMS: Administrative Efficiency;Advisory Committees;Alabama;Applications Grants;Area;Bioethics;Bioinformatics;Biometry;Budgets;cancer health disparity;Collaborations;Communication;Comprehensive Cancer Center;Data;data management;data sharing;Disparity population;education research;Ensure;Evaluation;experience;Funding;Goals;Human Resources;Infrastructure;Institution;Joints;Leadership;Lilium;Logistics;meetings;member;Minority Groups;Monitor;Morehouse School of Medicine;Office of Administrative Management;outreach;Pilot Projects;Policies;Preparation;Principal Investigator;Process;Productivity;Program Evaluation;programs;Progress Reports;Regulation;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Review Committee;Rice;Rivers;Science;Services;Supervision;symposium;Teleconferences;United States National Institutes of Health;Universities

PROJECT_TITLE: Admin Core


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Rare Diseases;Women's Health Research

ORG_CITY: STONY BROOK

ORG_DEPT: PATHOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Narrative This proposal tries to answer a major question in carcinogenesis: “How do harsh microenvironments select for hardwired metabolic phenotypes, such as Warburg Effect, leading to carcinogenesis”? Combining three high technology approaches of cancer evolutionary biology, mathematical modeling, and system biology, we propose to decipher the relationship between microenvironmental stress-induced genome evolution that results in hardwired phenotypic adaptation represented by a WE as an initiator of cancer. Solving this problem will have significance as it is a long-standing problem in cancer biology.

PI_NAMEs: DAMAGHI, MEHDI  (contact);SIQUEIRA SILVA, ARIOSTO S

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Acidosis;Acute;Address;aerobic glycolysis;Affect;Aneuploidy;Bar Codes;Benign;Biological Models;Biology;Breast Cancer Cell;Breast Carcinogenesis;Breast Epithelial Cells;Cancer Biology;carcinogenesis;Cell Survival;Cells;Chromatin;Clone Cells;Comedo;Computer Analysis;Data;Databases;Disease;Disseminated Malignant Neoplasm;Duct (organ) structure;Ecology;Environment;Epigenetic Process;epigenome;epigenomics;Epithelial Cells;Evolution;Exhibits;exome sequencing;Expression Profiling;Fermentation;fitness;Gene Silencing;Genes;Genetic;Genets;Genome;Genomics;Glucose;Heritability;HK2 gene;Human;Hypoxia;Immunohistochemistry;In Situ Lesion;Investigation;Lasers;Machine Learning;machine learning algorithm;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;mathematical model;MCF10A cells;Metabolic;metabolic phenotype;Modification;Molecular;Monitor;Multiple Myeloma;Mutation;Nature;neoplastic cell;Noninfiltrating Intraductal Carcinoma;Normal Cell;novel;nutrient deprivation;Outcome;overexpression;Oxygen;Pathway interactions;Patients;Pattern;Periodicity;Phenotype;Point Mutation;premalignant;Process;Proteins;Quantitative Reverse Transcriptase PCR;Sampling;single cell ATAC-seq;single-cell RNA sequencing;SLC2A1 gene;Starvation;stem;Stress;stressor;System;Systems Biology;Techniques;Technology;Testing;The Cancer Genome Atlas;Tissue Microarray;transcriptome;transcriptomics;tumorigenic;Warburg Effect;Work

PROJECT_TITLE: Ecology and Evolution of Breast Carcinogenesis


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE – PROJECT 3 We will perform a Ph1b/II clinical trial to evaluate the ability of hedgehog inhibitors to increase immune checkpoint inhibitor response in patients with ovarian cancer. We will determine if changes in blood chemokine levels and immune cell localization predicts response. Finally, we will assess the role of BIGH3 (TGF-β1induced protein) as a regulator of tumor immune cell infiltration and as a therapeutic target.

PI_NAMEs: BUCKANOVICH, RONALD J (contact)

PROJECT_TERMS: anti-PD-L1;arm;Binding;Biological Response Modifiers;Biopsy;Blood;cancer cell;Cancer Patient;Carcinoma;CD8-Positive T-Lymphocytes;cell motility;Cells;checkpoint therapy;chemokine;Clinical Trials;Correlative Study;CXCL9 gene;cytokine;Data;design;Dose;Effector Cell;Erinaceidae;Event;Exclusion;Fibroblasts;Fostering;genetic approach;Human;humanized mouse;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunosuppression;Immunotherapeutic agent;improved outcome;In Vitro;in vivo;Infiltration;inhibitor;inhibitor therapy;islet;Lead;Link;Macrophage;Malignant neoplasm of ovary;Measures;Mediating;Mediator;Mesenchymal Stem Cells;migration;Modeling;monocyte;mouse model;Mus;Myeloid Cells;nano-string;Natural Killer Cells;neutralizing antibody;new therapeutic target;Ovarian Carcinoma;patient prognosis;patient response;Patient-Focused Outcomes;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Phase;Phase II Clinical Trials;Phenotype;Physiologic pulse;Plasma;Platinum;preclinical study;predicting response;Prediction of Response to Therapy;predictive marker;primary endpoint;Progression-Free Survivals;Proteins;recruit;Recurrence;Reporting;Resistance;response;restoration;Role;Safety;secondary endpoint;single-cell RNA sequencing;smoothened signaling pathway;T cell receptor repertoire sequencing;T cell regulation;T-Cell Activation;T-Lymphocyte;Testing;TGFBI gene;therapeutic target;therapy outcome;Tissues;Transforming Growth Factor beta;translational study;treatment response;tumor;Tumor Immunity;tumor microenvironment;Tumor Tissue;Tumor-associated macrophages;tumor-immune system interactions;Tumor-infiltrating immune cells

PROJECT_TITLE: Project 3: Hedgehog Inhibition to Enhance Response to ICI Therapy


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ROCHESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Public Health Relevance. Riboswitches are metabolite-sensing elements found in the messenger RNAs of many bacterial pathogens. We discovered a very small riboswitch that senses preQ1 using ‘cooperativity’, whereby two identical metabolites are held in close proximity to improve each other’s affinity, which extends the riboswitch’s preQ1-sensing range in cells. This proposal will determine crystal structures of this novel preQ1 riboswitch, develop tools to quantify its cooperative sensing, and probe its function and conformation in live bacteria, thereby elucidating a new gene-regulatory pathway that is relevant to antibacterial discovery.

PI_NAMEs: WEDEKIND, JOSEPH E (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acylation;Address;Affinity;Agar;Anti-Bacterial Agents;antimicrobial;aptamer;Architecture;Attributes of Chemicals;Bacteria;Bacterial Genes;Binding;Biochemical;Biological Assay;Biological Models;Biological Process;biophysical techniques;Calorimetry;Cell Physiology;Cells;Chemicals;Computer software;Consensus;Consensus Sequence;Coupled;Crystallography;Data;Drug Targeting;Elements;Exhibits;experimental study;falls;Family member;flexibility;Fluorescence;forging;Foundations;Gene Expression Regulation;gene repression;Genes;Goals;Hand;human pathogen;Hydroxyl Radical;improved;In Vitro;innovation;insight;Ligand Binding;Ligands;Link;Liquid substance;Mediating;Messenger RNA;Microscopic;Modeling;Modification;Molecular;Molecular Conformation;molecular dynamics;mutant;Neisseria gonorrhoeae;next generation sequencing;novel;nucleobase;Outcome;pathogen;pathogenic bacteria;Pathway interactions;Play;Positioning Attribute;Primer Extension;Process;Proteins;public health relevance;Qualifying;Records;Regulatory Pathway;Reporter;Repression;Resolution;response;restraint;RNA;RNA Conformation;Role;sensor;Site;Site-Directed Mutagenesis;small molecule;Small RNA;software development;Structure;synergism;targeted treatment;Testing;therapeutic development;Titrations;tool;trait;Untranslated RNA;Work;Writing

PROJECT_TITLE: Mechanisms of Action On Non-Coding RNA Molecules


NIH_SPENDING_CATS: Cancer;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: RIVERS, DESIREE AVIA (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Advisory Committees;Alabama;anti-cancer research;Behavioral;Bioethics;Bioinformatics Shared Resource;Biometry;cancer education;cancer genomics;cancer health disparity;clinical trial enrollment;Clinical Trials;Communities;Community Healthcare;Community Outreach;Complex;Comprehensive Cancer Center;Data Collection;Development;Education;education research;ethnic minority;Evaluation;Event;evidence base;Evidence based program;experience;Feedback;Funding;Future;Goals;health care settings;high school;Impact evaluation;innovation;Institution;Joints;Leadership;Link;Logic;Malignant Neoplasms;Medical Students;meetings;Methods;Modeling;Molecular;Morehouse School of Medicine;Nature;Organizational Change;Outcome;Output;outreach program;Pilot Projects;Postdoctoral Fellow;Principal Investigator;Process;process evaluation;programs;racial minority;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Responsible Person;Rivers;Rural Community;Scientist;sound;synergism;theories;timeline;tool;Translating;Translational Research;undergraduate student;Universities;Urban Community;Work;Writing

PROJECT_TITLE: Planning and Evaluation Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Data Science;Digestive Diseases;Esophageal Cancer;Rare Diseases;Stomach Cancer

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: The overarching mission of the NCI’s Program on the Origins of Gastroesophageal Cancers and the six transdisciplinary R01 projects is to extend recent findings regarding molecular classifications and genomics of gastroesophageal cancers and examine and define how these cancers initially evolve at the cellular level. The Columbia Coordinating Center (CCC) will provide the necessary leadership, infrastructure, and oversight to support this consortium and optimize programmatic productivity. Training and mentorship of junior investigators, building collaborations and networks, and FAIR data sharing will be an emphasis.

PI_NAMEs: GENKINGER, JEANINE M.;HU, JIANHUA ;HUR, CHIN  (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Area;Award;Bioinformatics;Biometry;Cancer Research Network;Cells;Classification;Clinical;cloud based;Collaborations;collaborative approach;Communication;Data;Data Commons;Data Element;data harmonization;data portal;data sharing;Databases;Development;Ensure;Equity;Evaluation;experience;FAIR principles;Feedback;Future;gastroesophageal cancer;Genome;Genomics;Goals;in vitro Model;in vivo;Infrastructure;Institution;Knowledge;Leadership;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Medical center;meetings;Mentorship;Metadata;Methodology;Mission;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;multidisciplinary;New York;next generation;organizational structure;Pathology;prevent;Productivity;programs;Reproducibility;Research;Research Personnel;Research Project Grants;Resolution;Resource Sharing;Resources;Risk;Scientist;Secure;Standardization;Structure;success;symposium;synergism;Technology;Time;Training;Training Programs;Training Support;tumor initiation;Universities;Vision;web-accessible;Work;working group

PROJECT_TITLE: Coordinating Center for the Program on the Origins of Gastroesophageal Cancers


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE – TRANSLATIONAL PATHOLOGY CORE The Translational Pathology Core (TPC) is critical for achieving the goals of the Hillman Cancer Center (HCC) Ovarian Cancer SPORE. To support SPORE investigators and the ovarian cancer research community, the TPC will (I) acquire, process, store and/or disperse biospecimens as needed, (ii) provide pathology and clinical annotations and (iii) create patient-derived tumor models for preclinical studies. All work will be done in a regulated and standardized environment to maximize what is learned from each patient’s samples.

PI_NAMEs: MODUGNO, FRANCESMARY  (contact)

PROJECT_TERMS: Adipocytes;anti-cancer research;Area;Ascites;Award;Basic Science;biobank;Bioinformatics;Biological Specimen Banks;Biometry;Blood specimen;Bone Marrow;Cancer Center;Cancer Center Support Grant;Cancer Model;Cancer Patient;career;Cells;Clinic;Clinical;clinical care;Clinical Data;Collaborations;Communities;Consent;Core Grant;Cryopreservation;Cultured Tumor Cells;Data;data de-identification;data sharing;Databases;Development;Disease;Endothelial Cells;Ensure;Environment;Fibroblasts;Foundations;Freezing;Funding;Future;Genotype;Goals;Gynecologic;Gynecologic Oncologist;Gynecologic Oncology;Health Insurance Portability and Accountability Act;Human;Immune system;Immunocompromised Host;improved;improved outcome;Individual;individual patient;innovation;Laboratories;Leadership;Learning;Link;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;member;Mesenchymal Stem Cells;Metadata;mixed cell culture;Modeling;Mus;Myofibroblast;neoplastic cell;novel;Organoids;Outcome;Paraffin Embedding;Pathologic;Pathologist;Pathology;Patients;Pelvis;Peripheral Blood Mononuclear Cell;Persons;Pre-Clinical Model;preclinical study;preservation;Primary Neoplasm;Process;programs;Protocols documentation;repository;Research;Research Institute;Research Personnel;Research Project Grants;research study;Resources;Sampling;Secure;Services;Specimen;Standardization;stool sample;Suspensions;Testing;Therapeutic;Tissue Sample;Tissues;Training;Translational Research;translational study;Treatment outcome;tumor;tumor xenograft;Tumor-Derived;Update;Woman;Work;Xenograft Model

PROJECT_TITLE: Core B: TCP: Translational Pathology Core


ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative This is a partnership between Hampton University (HU) and the Tisch Cancer Institute (TCI) at Icahn School of Medicine at Mount Sinai that seeks to establish robust collaborations through on-site and online training and education to increase HU research capacity in the area of genetics and genomics and health disparities, using the examples of prostate and breast cancer. The final goal is to create a competitive and sustainable joint Center for Genetics and Genomics Cancer Research, encompassing the genetics and genomics aspects of health disparities to explain population differences in breast and prostate cancer occurrence and outcome.

PI_NAMEs: TAIOLI, EMANUELA  (contact)

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: Address;African American population;anti-cancer research;Area;Behavioral;Biological;Biometry;cancer epidemiology;cancer genetics;cancer genomics;cancer health disparity;cancer type;Clinical Investigator;Collaborations;Consultations;Coupled;Data;Data Collection;Detection;didactic education;Disparity;education research;Educational Activities;Educational Materials;Educational process of instructing;Ensure;Environment;Environmental Risk Factor;Epidemiology;epidemiology study;Etiology;experience;Exposure to;Extramural Activities;Faculty;faculty research;Feasibility Studies;Funding;Genetic;genetic epidemiology;Genetic Variation;genomic epidemiology;Genomics;Goals;hands on research;Health;Health Disparities Research;health disparity;improved;innovation;Institution;Interdisciplinary Study;Joints;Lead;Learning;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;Mentors;Methodology;Methods;Minority;model building;novel;Outcome;Pilot Projects;Population;Productivity;programs;proton therapy;Records;Registries;Research;Research Institute;Research Personnel;Research Project Grants;Resources;Scientist;Series;Site;social factors;statistics;Students;success;survivorship;Time;Training;Training Activity;Training and Education;Translational Research;Travel;treatment and outcome;treatment response;undergraduate education;Universities;Vulnerable Populations

PROJECT_TITLE: 1/2- Feasibility study to build a collaboration in genetics and genomic cancer research


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Prostate Cancer;Rare Diseases;Urologic Diseases

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative The Rapid Autopsy Program (RAP) biorepository for Pancreas and Prostate Cancer serves as a unique and highly utilized core associated with several NCI funded programs of research in pancreatic and prostate cancer at UNMC and outside institutions. As Director of the program, Dr. Grandgenett plays a major role in expanding the collection, and in the annotation and distribution of these biospecimens. The Director's contribution is essential to the continued success of the program and those dependent on it.

PI_NAMEs: GRANDGENETT, PAUL M (contact)

PROGRAM_OFFICER_NAME: NOTHWEHR, STEVEN F

PROJECT_TERMS: Address;anti-cancer research;Archives;Ascites;Autopsy;Award;biobank;Blood;blood-based biomarker;Cancer Center;Cancer Patient;Cancer Research Project;Cessation of life;Collaborations;Collection;design;Disease;Distant Metastasis;DNA;Drug or chemical Tissue Distribution;experience;Focus Groups;Freezing;Funding;Grant;Hour;Human;Individual;innovation;Institution;International;Knowledge;Laboratories;Leadership;Liquid substance;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Medical center;mid-career faculty;Modeling;Molecular;Nebraska;Neoplasm Circulating Cells;Normal tissue morphology;Oncology;Organ;Organoids;Patients;Play;Postdoctoral Fellow;Primary Neoplasm;Process;programs;Prostate;Proteins;Research;Research Personnel;Research Project Grants;Research Training;Residual state;Resources;RNA;Role;Sampling;Specialist;Specimen;success;Tissues;TNFRSF5 gene;Training;Universities;volunteer;Work;Xenograft procedure

PROJECT_TITLE: Critical Resources Provided by UNMC RAP Biorepository Stimulate Cancer Research


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative  Glaucoma is the leading cause of irreversible blindness throughout the world, and there are currently no options for restoration of vision in persons with blindness caused by this disease. Here we propose a series of novel strategies to advance the audacious goal of replacing retinal ganglion cells (RGCs), the output nerve cells of the eye, which form the optic nerve and are damaged in glaucoma. We will systematically test a series of manipulations to enhance the survival and integration of human induced pluripotent stem cell-derived RGCs in the glaucomatous retina.

PI_NAMEs: FORTUNE, BRAD ;MEYER, JASON STEPHEN (contact);OU, YVONNE ;SIVYER, BENJAMIN M

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Address;Anatomy;Astrocytes;Axon;Biology;Blindness;Brain;cell age;Cell Differentiation process;cell injury;Cell Line;Cell Survival;Cells;cellular development;Characteristics;clinically relevant;Communities;Complex;Data Set;designer receptors exclusively activated by designer drugs;Development;Disease;Donor person;Electrophysiology (science);Engraftment;Environment;Experimental Models;experimental study;Eye;FRAP1 gene;Future;ganglion cell;Gene Expression Profile;Genetic;Glaucoma;glial activation;Goals;Human;human induced pluripotent stem cells;Immunosuppressive Agents;improved;induced pluripotent stem cell;innovation;Knowledge;Modeling;Molecular;Nerve Regeneration;Neuroglia;neuroinflammation;neuronal replacement;Neurons;neurotoxic;novel;novel strategies;Optic Nerve;optic nerve disorder;Output;overexpression;Persons;Process;receptor;Rejuvenation;repaired;Research;Research Personnel;Resources;Retina;retina transplantation;Retinal Degeneration;retinal ganglion cell degeneration;Retinal Ganglion Cells;retinal neuron;Series;sight restoration;Signal Transduction;Site-Directed Mutagenesis;sound;synaptogenesis;Testing;Therapeutic;Thrombospondins;tool;translational approach;Translations;transmission process;Transplantation;Viral Vector;Vision Disorders;Visual;Visual impairment;Visual System;Visually Impaired Persons;Work

PROJECT_TITLE: Overcoming Barriers to retinal ganglion cell replacement in experimental glaucoma


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Urologic Diseases

PI_NAMEs: SINGH, SHAILESH  (contact)

PROJECT_TERMS: African American;African American population;Age;Alabama;anti-cancer research;Aptitude;Biomedical Research;cancer education;cancer health disparity;Cancer Research Project;cancer therapy;cancer type;career;career development;Career Mobility;Caring;Clinical Research;college;Colorectal Cancer;Communication;Communities;Comprehensive Cancer Center;Death Rate;Diagnosis;Diverse Workforce;Education;education research;Educational Activities;Educational Curriculum;ethnic disparity;ethnic diversity;ethnic minority;Evaluation;experience;Exposure to;Faculty;Feedback;Fellowship;Funding;Future;Goals;graduate school;graduate student;Grant;hands on research;Health;Health Disparities Research;Healthcare;high school;High School Student;Immersion;improved;Incidence;Informatics;Infrastructure;Institution;interest;Interview;Joints;Laboratories;Latinx;Learning;Link;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;medical schools;Medical Students;member;men;Mentors;Methods;Minority Groups;Morehouse School of Medicine;mortality;Movement;Outcome;outreach;Patients;Policies;Postdoctoral Fellow;Productivity;programs;Publications;racial disparity;racial diversity;racial minority;recruit;Research;Research Personnel;Research Project Grants;response;rural area;rural setting;Science;Scientist;skills;social media;statistics;Structure;Students;summer program;Training;undergraduate student;Underrepresented Minority;underserved minority;United States National Institutes of Health;Universities;urban area;urban setting

PROJECT_TITLE: Research Education Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: OXFORD

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF OXFORD

ORG_ZIPCODE: OX1 2JD

PHR: PROJECT NARRATIVE Frequent relapse is the major cause of morbidity in Plasmodium vivax malaria, causing anaemia, developmental delay, and intrauterine growth restriction with consequent neonatal death. Tafenoquine is a major advance as it provides single dose relapse prevention (radical cure) but, at the currently recommended dose, its efficacy in the Asia-Pacific regions (where Plasmodium vivax is the predominant cause of human malaria) is low. This study will assess a tafenoquine dose 50% higher than currently recommended, predicted to reduce treatment failure by more than half, and which will thereby provide the effective radical cure necessary to reduce morbidity and accelerate Plasmodium vivax malaria elimination.

PI_NAMEs: CHU, CINDY S (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Acceleration;Acute;Adult;Aftercare;Aminoquinolines;Anemia;Anti-malarials;artemether;Asia;benflumetol;Bibliography;Blood;Child;Chloroquine;Clinical Trials;Country;CYP2D6 gene;Data;density;design;detection method;Developmental Delay Disorders;Dose;Double-Blind Method;Drug Interactions;Enrollment;Erythrocytes;Event;Falciparum Malaria;Far East;Fetal Growth Retardation;gastrointestinal symptom;genome sequencing;Genotype;Glucosephosphate Dehydrogenase;Goals;Guidelines;Hematocrit procedure;Hemoglobin;Human;improved;Incidence;Individual;individual patient;Infection;Liver;Malaria;Measurement;Measures;Meta-Analysis;Methemoglobin;Methemoglobinemia;Monitor;Morbidity - disease rate;Mutation;Neonatal Mortality;Oceania;Odds Ratio;Parasitemia;Parasites;Participant;Patients;Persons;Pharmaceutical Preparations;pharmacometrics;Phase;Plasma;Plasmodium vivax;policy recommendation;Polymerase Chain Reaction;Pregnant Women;Primaquine;Primary Infection;Production;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Recurrence;Relapse;relapse prevention;Research;response;Safety;safety assessment;Schedule;Southeastern Asia;Statistical Models;Testing;Therapeutic;Time;transmission process;Treatment Failure;Urine;Visit;Vivax Malaria;Whole Blood

PROJECT_TITLE: Optimizing the dose of tafenoquine for the radical cure of Plasmodium vivax malaria in Southeast Asia


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE – BIOSTATISTICS/BIOINFORMATICS CORE The Biostatistics/Bioinformatics Core provides specialized analysis services to the clinical, laboratory, translational and “-omics” research projects of the Hillman Cancer Center Ovarian Cancer SPORE to ensure that experiments are efficiently designed and data are analyzed in a rigorous and reproducible fashion by analysts familiar with cancer in general and ovarian cancer in particular.

PI_NAMEs: TATSUOKA, CURTIS M. (contact)

PROJECT_TERMS: Aftercare;Animals;anti-cancer research;Applications Grants;Bayesian learning;Bioinformatics;Biological;Biometry;Biostatistics Core;Cancer Center;career development;Clinic;Clinical;Clinical Cancer Center;Clinical Data;Clinical Protocols;Clinical Research;compare effectiveness;Computer Analysis;Data;Data Analyses;data management;data quality;data quality/integrity;data sharing;design;Development;experience;Experimental Designs;experimental study;Genomics;Goals;Immunohistochemistry;Immunologics;In Vitro;in vivo;Individual;innovation;Laboratories;Machine Learning;Malignant neoplasm of ovary;Malignant Neoplasms;Manuscripts;member;Methods;multidimensional data;Nature;Pathology;Patients;Preparation;Program Development;Protocols documentation;Quality Control;Reporting;Reproducibility;Reproduction spores;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Services;Specimen;stem;Techniques;Translational Research;translational study;Visualization;Work;Writing

PROJECT_TITLE: Core C: BBC: Biostats and Bioinformatics Core


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: FARMINGTON

ORG_NAME: POTENTIOMETRIC PROBES, LLC

ORG_STATE: CT

PHR: Project Narrative Potentiometric Probes Potentiometric Probes is developing fluorescent dyes that convert electrical signals of heart cells and tissue into optical signals that can be recorded with cameras. These probes allow researchers to screen drugs rapidly for cardiotoxicity, as well as to study how electrical signals are generated and propagate in the heart, providing insights into mechanisms of genetic diseases and links to cardiac arrhythmias and failure.

PI_NAMEs: ACKER, COREY  (contact)

PROGRAM_OFFICER_NAME: BILLINGSLEA, EDDIE

PROJECT_TERMS: Action Potentials;Arrhythmia;Basic Science;Biological Assay;Businesses;calcium indicator;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;Cardiotoxicity;Catalogs;Cell Line;Cell membrane;Cells;Chemicals;chromophore;Clinical;clinical imaging;commercialization;Communities;Connecticut;design;Development;drug action;drug discovery;Drug Screening;Drug toxicity;Dyes;Electrodes;Electrophysiology (science);experimental study;Fluorescence;Fluorescent Dyes;Future;Generations;Genetic Predisposition to Disease;Goals;Growth;Heart;heart cell;Heart failure;Heart Research;high resolution imaging;high throughput screening;human induced pluripotent stem cells;human stem cell-derived;Image;improved;in vivo;Individual;induced pluripotent stem cell derived cardiomyocytes;insight;invention;Legal patent;Licensing;Light;light intensity;Link;Maps;Marketing;Measures;Methods;Morphologic artifacts;Motion;Neurosciences;Noise;novel;novel therapeutics;Optics;optogenetics;Organ;Patients;Penetration;Performance;personalized diagnostics;personalized medicine;Pharmaceutical Preparations;Pharmacology;Phase;Physiology;Preparation;Property;Proteins;ratiometric;rational design;Reagent;Records;Research;research and development;Research Personnel;Resolution;Safety;Scientist;screening;Signal Transduction;Small Business Innovation Research Grant;Source;spatiotemporal;Speed;Stains;Technology;Testing;Thick;Time;tissue/cell culture;Tissues;tool;Toxic effect;Toxicology;Universities;voltage;voltage sensitive dye;water solubility;Work

PROJECT_TITLE: Optimized Ratiometric Voltage-Sensitive Dyes for Cardiac Research, Safety Pharmacology


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;African American;African American population;Alabama;anti-cancer research;Attitude;Awareness;Behavior;Belief;Biomedical Research;cancer clinical trial;cancer genomics;cancer health disparity;Cancer health equity;Cancer Patient;cancer prevention;cancer risk;cancer therapy;Catchment Area;Clinical;Clinical Research;clinical trial enrollment;Clinical Trials;Communities;Community Health;Comprehensive Cancer Center;design;Disease;Early Diagnosis;Education;education resources;Environment;Equity;Evaluation;evidence base;Genetic;Genomics;Goals;health disparity populations;Institution;interest;Joints;Knowledge;Latinx;Latinx population;Logic;Malignant Neoplasms;Medicine;Minority Participation;Modeling;Morehouse School of Medicine;National Cancer Institute;Outcome;Outcome Measure;outreach;Participant;patient navigation;Population;Population Heterogeneity;precision oncology;preference;Prevention;Privacy;programs;recruit;Research;Research Project Grants;research study;Resources;Rural Community;Safety;Scientific Advances and Accomplishments;Services;Standardization;Surveys;Tablets;Technology;theories;Therapeutic Clinical Trial;Training;Trust;Underserved Population;United States National Institutes of Health;Universities;Urban Community

PROJECT_TITLE: Outreach Core


ORG_CITY: TUSCALOOSA

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PHR: Project Narrative This project establishes the rules for integrated design of a platform technology for oral delivery of pharmaceutical drugs with diverse physicochemical attributes. In doing so we will develop a mathematical model that can significantly advance the discovery, development, and preclinical-to-clinical translation of drug- laden polymer nanoparticles designed for oral administration.

PI_NAMEs: MAJETI, RAVIKUMAR N (contact);SHAH, DHAVAL K

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: ABCB1 gene;absorption;Affinity;amphiphilicity;Behavior;Binding Sites;Biological Availability;Blood;Blood - brain barrier anatomy;Blood-Retinal Barrier;Canis familiaris;Cannulations;Cells;Characteristics;Chemistry;clinical practice;clinical predictors;clinical translation;Cyclosporine;Data;data modeling;density;design;Designer Drugs;Development;Dose;Drug Carriers;Drug Delivery Systems;drug repurposing;Drug Transport;drug-like compound;Encapsulated;Engineering;Excipients;Exhibits;extracellular;Family suidae;flexibility;functional group;gambogic acid;Goals;Growth;Health Technology;Human;hydrophilicity;improved;in silico;In Vitro;in vivo;insight;Intestines;Investigation;Knockout Mice;Knowledge;Lead;Length;Ligand Binding;Ligands;lymphatic duct;mathematical model;Mathematics;Mechanics;Mediating;Metabolism;Modeling;Modification;mouse model;Mus;nanocarrier;nanomedicine;nanoparticle;nanopolymer;Nanostructures;nanosystems;new chemical entity;next generation;novel;novel strategies;Oral;Oral Administration;Peptide Hydrolases;Performance;Periodicals;Pharmaceutical Preparations;pharmacokinetic model;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;physiologically based pharmacokinetics;Physiology;Polyesters;Polymers;Portal vein structure;pre-clinical;Process;Property;Race;rational design;Rattus;receptor;Receptor Cell;receptor mediated endocytosis;Regimen;Research;Research Personnel;Rodent;Role;Route;Scheme;Series;small molecule;stoichiometry;Structure;Structure-Activity Relationship;Surface;System;Tea;technology platform;TFRC gene;Toluene;tool;trafficking;transcytosis;Transferrin;Translations;uptake;Vertebral column;Work

PROJECT_TITLE: Polyesters with controlled topologies for probing transcytosis at the gut-blood barrier

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE – DEVELOPMENTAL RESEARCH PROGRAM (DRP) The Developmental Research Program (DRP) of the UPMC Hillman Cancer Center (HCC) Ovarian Cancer SPORE seeks to identify, fund and facilitate translationally-driven, innovative pilot projects in cancer through broad solicitation of proposals, vigorous peer-review, and assessment of pilot progress with intent to develop mature projects worthy of extramural support (including SPORE rebid efforts). Submissions from individuals underrepresented in the biomedical sciences, investigators new to this field, and high-risk, high-gain proposals will be strongly encouraged and all awardees will have the full support of SPORE and HCC resources to increase likelihood for success.

PI_NAMEs: OLAWAIYE, ALEXANDER  (contact)

PROJECT_TERMS: Advocate;Annual Reports;anti-cancer research;Application procedure;Area;Award;Bioinformatics;Biometry;Cancer Center;Cancer Research Project;Cessation of life;Clinical;Clinical Trials;cohort;Collaborations;Communities;Core Facility;Data;Development;disability;Disease;Doctor of Philosophy;Early Diagnosis;Electronic Mail;Eligibility Determination;Ensure;equity, diversity, and inclusion;experience;Extramural Activities;Feedback;Financial Support;flexibility;Fostering;Funding;Goals;high reward;high risk;Hospitals;Incubators;Individual;Infrastructure;innovation;Institution;inter-institutional;Investments;Joints;Laboratories;Lead;Malignant neoplasm of ovary;Malignant Neoplasms;meetings;member;Mentors;Minority;minority investigator;Minority-Serving Institution;Monitor;Morbidity - disease rate;mortality;mouse model;next generation;novel;Outcome;outreach;Patients;peer;Peer Review;Pilot Projects;Population;Population Sciences;predictive marker;Prevention;Process;Prognostic Marker;Program Research Project Grants;programs;Progress Reports;recruit;repository;Research;Research Personnel;Research Project Grants;Resources;Science;Scientist;Sister;Specimen;standard of care;success;Testing;therapy resistant;Tissues;translational impact;tumorigenesis;Underrepresented Minority;United States National Institutes of Health;Universities;Vertebral column;web site;Woman;Work

PROJECT_TITLE: DRP: Developmental Research Program


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Cancer;Clinical Research;Emerging Infectious Diseases;Gene Therapy;Genetics;Hematology;Immunization;Immunotherapy;Infectious Diseases;Influenza;Nanotechnology;Pneumonia and Influenza;Vaccine Related

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Broad patient access to the engineered T cell therapies is currently limited by the expensive and complicated ex vivo manufacturing process. This proposal aims to develop a new approach to reprogram circulating influenza virus-specific T cells in the body against cancer. This approach would lessen the manufacturing hurdle and allow for the use of influenza vaccination to boost the anti-cancer efficacy of engineered T cells, thereby paving the way for the improved patient access and treatment outcome of engineered T cell therapy for cancer patients.

PI_NAMEs: SU, FANG-YI  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Adoptive Transfer;Advisory Committees;anti-cancer;Antibodies;anticancer activity;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;antiviral immunity;Autoimmune;B-Lymphocytes;Benchmarking;Biodistribution;Biological Assay;bioluminescence imaging;Biotinylation;Blood;Bypass;cancer cell;Cancer Model;Cancer Patient;cancer therapy;CAR T cell therapy;career;CD19 gene;cell killing;Cell Line;Cell Maturation;cell type;Cells;Cellular biology;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Coculture Techniques;cohort;cost;cost efficient;CRISPR therapeutics;CRISPR/Cas technology;cytokine;cytotoxicity;Democracy;Development;Disease;DNA;Doctor of Medicine;Doctor of Philosophy;Dose;Effectiveness;Encapsulated;engineered T cells;Environment;Epitopes;exhaustion;experimental study;Face;Flow Cytometry;Frequencies;Future;Genes;Genome;Genome engineering;Goals;Hematologic Neoplasms;Hematology;Histocompatibility Antigens Class I;HLA-A gene;HLA-A2.1;Human;Immunity;Immunotherapy;improved;In Situ;in vivo;Influenza;Influenza A virus;influenza infection;Influenza vaccination;influenzavirus;Kinetics;Knowledge;Lead;Lentivirus;lipid nanoparticle;Liver;Major Histocompatibility Complex;Malignant Neoplasms;manufacture;manufacturing process;Memory;Mentors;Mentorship;Messenger RNA;mouse model;mRNA delivery;Multiple Myeloma;Mus;nanoparticle;new technology;novel strategies;Oncology;Patients;peptide I;Peptides;Peripheral Blood Mononuclear Cell;Phase;Phenotype;Polymers;Population;Production;programs;proliferation potential;receptor;receptor expression;recombinant virus;Recombinants;Regulatory T-Lymphocyte;Research;Resources;Safety;seasonal influenza;Self Tolerance;Specificity;Spleen;Stains;success;System;T cell differentiation;T cell therapy;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic Studies;Time;Toxic effect;Transfection;Transgenes;Translations;Treatment Efficacy;Treatment outcome;Universities;unvaccinated;Vaccinated;Vaccination;vaccination strategy;Viral;Virion;Virus;Virus Diseases;Work

PROJECT_TITLE: Democratizing CAR T cell therapy by in situ programming of virus-specific T cells

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: PENTZ, REBECCA D (contact)

PROJECT_TERMS: Address;Advocate;Alabama;anti-cancer research;Behavioral;Behavioral Research;Bioethical Issues;Bioethics;Bioethics Consultants;Biological Sciences;Biomedical Research;cancer clinical trial;cancer genomics;cancer health disparity;Clinical;Clinical Research;Clinical Trials;Collaborations;Communities;Community Health;Competence;Comprehensive Cancer Center;Consultations;design;Education;Education and Outreach;education research;Educational process of instructing;Endowment;Enrollment;Ensure;Ethical Issues;Ethics;ethnic minority;Evaluation;Faculty;Genomics;Good Clinical Practice;Guidelines;health disparity;Health Policy;Human Resources;Informed Consent;Institution;Laws;Logic;Malignant Neoplasms;medically underserved;Methods;minority communities;Modeling;Morehouse School of Medicine;new technology;online course;Outcome;outreach;Participant;patient navigator;Patients;Policies;Process;programs;racial minority;Recommendation;Research;Research Ethics;Research Personnel;Research Project Grants;Resource Sharing;rural area;social;Students;symposium;Thinking;tool;Training;Trust;undergraduate student;underserved community;underserved urban area;Universities

PROJECT_TITLE: Core 1: Bioethics Shared Resource


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE – CAREER ENHANCEMENT PROGRAM (CEP) The Hillman Cancer Center Ovarian SPORE Career Enhancement Program (CEP) is designed to foster the growth of a new generation of diverse scientists dedicated to ovarian cancer research leading to improvements in the prevention, detection, and therapy of this deadly disease. To accomplish this, we have established numerous collaborations to identify the best applicants and increase the number of underrepresented minorities in the Ovarian Cancer SPORE, to benefit both this SPORE and the entire ovarian cancer research community.

PROJECT_TERMS: Advocate;anti-cancer research;Applications Grants;Award;Basic Science;Bioinformatics;Biological Models;Biometry;cancer care;Cancer Center;Cancer Research Project;career;career development;Career Mobility;Clinic;Clinical;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;Dedications;Department chair;design;Detection;Development;Disabled Persons;Discipline of obstetrics;Disease;Ensure;Environment;Epidemiology;Equilibrium;Ethnic Population;experience;Extramural Activities;Faculty;Feedback;Fostering;Funding;Future;Generations;Goals;Group Meetings;Growth;Gynecology;Hematology;Home;Human;improved;Individual;insight;Institution;Investments;Joints;Leadership;Malignant neoplasm of ovary;Malignant Neoplasms;Medicine;meetings;member;Mentors;mid-career faculty;Minority-Serving Institution;Mission;Morehouse School of Medicine;next generation;Nursing Faculty;Oncology;outreach;Ovarian;Patients;Peer Review;Performance;Population Sciences;Positioning Attribute;Postdoctoral Fellow;Preparation;Prevention;Procedures;Process;professor;Program Development;programs;Puerto Rico;racial population;recruit;Reproductive Sciences;Research;Research Institute;Research Personnel;Research Project Grants;Research Training;Resources;Science;Scientist;Series;Services;Specimen;Structure;success;System;Target Populations;Tissues;Training;translational cancer research;translational impact;Translational Research;translational scientist;Translations;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Woman;working group

PROJECT_TITLE: CEP: Career Enhancement Program


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The decline in sex hormones (estrogen and testosterone) with aging can increase risk for certain diseases; osteoporosis is a well-known example. This is particularly important for women’s health because the loss of estrogen occurs during mid-life, whereas the loss of testosterone in men occurs much later in life. The Colorado Specialized Center of Research Excellence on Sex Differences (SCORE) will advance novel ideas for how the loss of estrogen increases fat gain in the abdominal region, which increases risk for heart disease and diabetes, and strategies that may be effective in preventing this.

PI_NAMEs: KOHRT, WENDY M (contact)

PROGRAM_OFFICER_NAME: HE, CHUNYAN

PROJECT_TERMS: Abdomen;abdominal fat;Acceleration;Address;Advisory Committees;Aging;aging process;Area;Award;Benchmarking;Bioenergetics;Biological;Biometry;cardiometabolism;career;career development;Career Mobility;Centers of Research Excellence;Chronic Disease;Clinical;Clinical Sciences;clinical translation;Colorado;Communities;data management;Diabetes Mellitus;Disease;Education;Educational Activities;Educational Curriculum;Elderly;Estradiol;Estrogens;Evaluation Research;Exercise;expectation;experience;Faculty;Failure;Family;Fatty acid glycerol esters;Female;Functional disorder;Goals;gonad function;Gonadal Steroid Hormones;Grant;Health;heart disease risk;Homeostasis;improved;innovation;Institution;Interdisciplinary Study;interest;investigator training;Knowledge;Kynurenine;Leadership;Life;male;Mediating;Medical;meetings;men;Menopause;Mentors;Metabolic;Metabolism;middle age;Midlife women;Modeling;multidisciplinary;next generation;novel;nutrition;Obesity;Osteoporosis;Ovarian;Pathway interactions;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;pre-clinical;prevent;Process;Productivity;Program Development;programs;Recording of previous events;Regulation;Research;Research Personnel;Research Project Grants;Resources;Risk;Scientist;sex as a biological variable;Sex Differences;Specialized Center;symposium;synergism;Testosterone;Time;Training;Training Activity;Training Programs;translational pipeline;Translational Research;Tryptophan;Universities;Visit;Wages;Withdrawal;Woman;Women's Health;women's reproductive health

PROJECT_TITLE: Bioenergetic and Cardiometabolic Consequences of the Loss of Gonadal Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-A(70)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

PI_NAMEs: MUBASHER, MOHAMED E. (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Alabama;anti-cancer research;Applications Grants;Basic Science;Behavioral Sciences;Bioethics;Bioinformatics;bioinformatics resource;Bioinformatics Shared Resource;biomedical informatics;Biometry;cancer education;cancer health disparity;Cancer Research Project;career;career development;ChIP-seq;Clinical Research;Collaborations;Comprehensive Cancer Center;computer science;Consultations;Data;Data Analyses;data management;data mining;Data Science;Dedications;Development;DNA sequencing;Education;education research;Ensure;Epidemiology;Epigenetic Process;Evaluation;exome sequencing;Faculty;Funding;Grant;Incidence;Informatics;Institution;Manuscripts;Medical;Medicine;member;Mentorship;metabolomics;Methodology;Methods;Methylation;microbiome research;Minority-Serving Institution;miRNA expression profiling;Morehouse School of Medicine;mortality;multiple omics;next generation sequencing;outreach;Pathology;Pilot Projects;population based;Preparation;Productivity;professor;programs;racial disparity;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Risk;single cell analysis;single cell genomics;skills;sound;statistics;success;Technical Expertise;Training;transcriptome sequencing;Translational Research;Ubiquitination;Universities;Work

PROJECT_TITLE: Core 2: Biostatistics/Bioinformatics Shared Resource


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome;Prevention;Rare Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative Kaposi’s sarcoma-associated herpesvirus (KSHV) causes several human cancers including Kaposi’s sarcoma, the most common cancer in AIDS patients. KSHV infection and Kaposi’s sarcoma inflict morbidity and mortality to the society in US and worldwide, which particularly affect underrepresented people living with HIV (PLWH) and cancer. This project will identify the factors that contribute to the development and therapeutic outcome of Kaposi’s sarcoma, thus providing the scientific basis for developing novel prevention and treatment approaches to benefit the patients.

PI_NAMEs: GAO, SHOU-JIANG  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Africa;African;Animal Model;Antibodies;antiretroviral therapy;Bacteria;Biology;Blood;cancer specimen resource;case control;CD14 gene;Cell Communication;Cell Proliferation;Cells;Clinical;Clinical Research;Clinical Sciences;co-infection;cohort;comorbidity;complement pathway;Complex;Computational Biology;cytokine;Data;Development;Disease Outcome;dysbiosis;Epidemiology;Flagellin;Gene Expression Profile;Genes;Goals;health disparity;Herpesviridae Infections;HIV;HIV Infections;Human;Human Herpesvirus 8;Immune;Immune response;Immunocompromised Host;Immunologics;In Situ;Infection;Inflammation;Inflammatory;Innate Immune Response;innovation;insight;Kaposi Sarcoma;Laboratories;lipopolysaccharide-binding protein;Lipopolysaccharides;longitudinal analysis;Longitudinal cohort;Machine Learning;machine learning algorithm;Malignant Neoplasms;metaplastic cell transformation;Methods;microbial;microbiome;microbiota;Modeling;Molecular;Morbidity - disease rate;mortality;novel;Oral;Outcome;Palate Kaposi's Sarcoma;Pathogenesis;Patients;Population;Poverty;pre-clinical;Predictive Factor;predictive marker;Prevention;Preventive;prognostic;Prognostic Marker;prognostic value;Research Personnel;response;Role;single cell sequencing;skin organogenesis;Societies;Specimen;statistics;Technology;Therapeutic;Therapeutic Agents;therapeutic target;therapeutically effective;therapy outcome;Time;TLR4 gene;Tobacco use;Translational Research;tumor;tumorigenesis;Underrepresented Populations;Validation;Visceral;Work

PROJECT_TITLE: Impact of microbiota on AIDS-Kaposi’s sarcoma development and therapy


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Health Relevance Statement The goal of this research is to develop new statistical methods to study the mechanism of disease causing genetic variants by gene regulatory networks. Many diseases are caused by and/or associated with altered gene regulation. Results from this research will enable a more effective analysis of the gene regulatory mechanisms relevant to disease.

PI_NAMEs: DUREN, ZHANA  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Affect;Alleles;causal variant;Cells;Comprehension;Computational Biology;Data;Data Set;Disease;disease mechanisms study;Elements;epigenome;epigenomics;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;genetic variant;Genome;Genotype;Genotype-Tissue Expression Project;Goals;Health;Human;human reference genome;Individual;Joints;Linkage Disequilibrium;Maps;Methods;Modeling;Network-based;Persons;Phenotype;population based;precision drugs;precision medicine;Quantitative Trait Loci;Regulatory Element;Research;response;Sampling;Source;Statistical Methods;transcription factor;Untranslated RNA;Variant

PROJECT_TITLE: Statistical methods for interpretation of genetic variants by gene regulatory networks

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Antibodies are assembled from gene segments via a process termed VDJ recombination that requires DNA rearrangement. We propose to examine the chromosomal architecture that spatially organizes V gene segments and makes them available for use during VDJ recombination. Our studies address questions of how antibody genes are chosen for recombination in the preselected repertoire and will help us understand how to refine vaccine development to provide the efficient immune responses.

PI_NAMEs: KENTER, AMY L (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: 3-Dimensional;Address;Antibodies;Antibody Repertoire;Antigen Receptors;Architecture;B-Cell Development;B-Lymphocytes;Binding;Bone Marrow;Breeding;Cell Line;Cell Nucleus;Cell Physiology;Cells;Chromatin;Chromatin Loop;Chromatin Structure;chromosome conformation capture;Chromosome Territory;Confocal Microscopy;Dependence;Development;Distal;DNA;Elements;Enhancers;Environment;Exons;Foundations;Frequencies;Gene Rearrangement;Genes;Genetic;Genetic Recombination;Genetic Transcription;Genome;Genomics;Histones;IGH@ gene cluster;Immune response;Immunoglobulins;Individual;Ions;Knockout Mice;Link;Lymphoid Cell;Maps;Mediating;Methodology;Methods;Molecular;Molecular Conformation;Mus;novel;Nuclear;Nucleic Acid Regulatory Sequences;Physical condensation;Process;promoter;Property;Proteins;Receptor Gene;recombinase;Regulatory Element;response;Series;Site;spatial relationship;Stimulus;Structure;superresolution microscopy;timeline;V(D)J Recombination;vaccine development

PROJECT_TITLE: Impact of novel enhancers on Igh repertoire diversity

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


PROJECT_TERMS: Acceleration;Advisory Committees;anti-cancer research;Applications Grants;base;cancer education;cancer genetics;cancer genomics;Collaborations;Communication;Development;Distance Learning;Education;Electronic Mail;Faculty;Feasibility Studies;Fostering;Funding;Genetic;Genomics;Goals;Grant;Human Resources;Institution;Leadership;medical schools;meetings;member;Monitor;Online Systems;Persons;programs;Progress Reports;Publications;Research;Research Personnel;Research Project Grants;Schedule;Site;symposium;System;Teacher Professional Development;Training;Training and Education;Training Programs;translational cancer research;translational genomics;United States National Institutes of Health;Universities;Update;Videoconferencing;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Contraception/Reproduction;Estrogen;Heart Disease;Menopause;Nutrition;Obesity;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Menopause increases cardiovascular disease risk due to changes in the hormone environment and adverse changes in cardiometabolic function. The research findings should provide new information on the impact of increased abdominal adiposity on vascular function with estrogen deficiency. These findings may lead to the development of novel therapeutic targets to prevent menopause-related cardiometabolic dysfunction and reduce the risk for cardiovascular disease.

PI_NAMEs: MOREAU, KERRIE  (contact)

PROJECT_TERMS: Abdomen;abdominal fat;Acceleration;Acute;Adipocytes;adipokines;Adipose tissue;age effect;age related;Aging;aging process;Agonist;Animals;Anti-Inflammatory Agents;Antioxidants;Area;Arteries;Attenuated;Back;Bioenergetics;Blood;Blood Vessels;Body fat;Body mass index;brachial artery;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Cell Culture Techniques;Chronic;Collaborations;Colorado;cytokine;Data;Development;Endocrine Glands;Endothelial Cells;endothelial dysfunction;Endothelium;Energy-Generating Resources;Environment;Enzymes;ESR1 gene;Essential Amino Acids;Estradiol;Estradiol Antagonists;Estrogen deficiency;Fatty acid glycerol esters;Functional disorder;Generations;GNRH1 gene;gonad function;Gonadal Hormones;Gonadal Steroid Hormones;Gonadotropin Hormone Releasing Hormone;Health;Hormone Antagonists;Hormones;Human;Impairment;improved;Inflammatory;insight;Intervention;Knock-out;Knowledge;Kynurenic Acid;Kynurenine;Link;Measures;Mediating;Mediator;men;Menopause;Metabolic dysfunction;Metabolism;Modeling;new therapeutic target;Nicotinamide adenine dinucleotide;Nitric Oxide;Obesity;obesogenic;older men;Ovarian;Ovarian Ablation;Ovarian hormone;Ovariectomy;Oxidative Stress;Participant;Pathway interactions;Perimenopause;Peripheral;Placebos;Plasma;Postmenopause;preclinical study;Premenopause;prevent;Process;Production;Property;Quinolinic Acid;Randomized;Regulation;Research;response;Risk Factors;Risk Reduction;Role;Scientific Advances and Accomplishments;Serotonin;Serum;Signal Pathway;subcutaneous;Testosterone;Tissues;Tryptophan;Vascular Diseases;Vascular Endothelial Cell;vascular endothelial dysfunction;Vasodilation;Visceral;Visceral fat;Withdrawal;Woman

PROJECT_TITLE: Cardiometabolic Consequences of the Loss of Ovarian Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-A]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Autoimmune Disease

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE A major function of the immune system is to discriminate between self and non-self, but occasionally immune cells mistake self-molecules for non-self and attack the body’s own healthy cells, triggering auto-immune diseases. In most cases, the identity of the self-molecules that trigger auto-immunity is unknown. This project will explore the auto-immune potential of an entirely uncharted pool of self-molecules, called ‘microproteins’, with the long-term goals to unlock novel therapeutic strategies for autoimmune diseases and understand the forces that govern microprotein biology.

PI_NAMEs: CARVUNIS, ANNE-RUXANDRA  (contact);JOGLEKAR, ALOK ;SUBRAMANIAM, ARVIND RASI

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Adaptive Immune System;Amino Acid Sequence;Amino Acids;Animal Model;Anti-Bacterial Agents;Antigens;antimicrobial;Atlases;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;Automobile Driving;Biological;Biological Models;Biology;cell growth;Cell model;Cell surface;Cells;Code;dark matter;Data;Data Analyses;Data Set;Development;Disabling;Discrimination;Education;Epitopes;Evolution;Exhibits;experimental study;gain of function;Gatekeeping;Genetic;Genetic Screening;Genome;genome annotation;genome-wide;Genomics;Goals;Immune;immune health;Immune system;Immune System Diseases;immune system function;Immune Tolerance;Immunity;immunogenic;Immunologic Surveillance;Immunologics;Individual;innate immune function;Innate Immune Response;Innate Immune System;innovation;insight;Insulin-Dependent Diabetes Mellitus;Knock-out;Knowledge;Literature;loss of function;Mammals;Mediating;Modeling;Modernization;Molecular;mouse model;Mus;Mutation;Natural Immunity;novel;novel therapeutic intervention;Open Reading Frames;Organism;pathogen;Pattern;Peptides;Physiological;Physiology;pressure;Process;protein expression;protein function;Proteins;proteogenomics;Proteome;Publishing;Recording of previous events;Research;ribosome profiling;Role;Shapes;Structure;T-Lymphocyte;T-Lymphocyte Epitopes;Technology;Testing;Thymus Gland;Time;Tissues;Transcript;transcriptome;translatome;Viral;Work

PROJECT_TITLE: Unraveling microprotein biology with an evolutionary-immunological framework


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Social Determinants of Health

PHR: Project Narrative: TRAINING AND EDUCATION PROGRAM Diverse investigators play an integral role in identifying novel research questions, perspectives, and solutions to complex biomedical challenges. Yet, diversifying the biomedical research workforce remains a major challenge in the US, despite the fact that underrepresented minorities make up the most rapidly growing segment of the US population. Thus, in a unique partnership between the Icahn School of Medicine at Mount Sinai and Hampton University, we propose to provide hybrid training and education to increase the research capacity, engagement, and success of the HU scientific workforce, with particular emphasis on genetics and genomics and cancer disparities research.

PI_NAMEs: BENN, EMMA KATHERINE TARA (contact)

PROJECT_TERMS: anti-cancer research;Appointment;Area;biological systems;Biomedical Research;Biometry;cancer genomics;cancer health disparity;Clinical;Clinical Research;Collaborations;community engaged research;Complex;Coupled;Data Science;design;Development;Discipline;doctoral student;early-career faculty;education research;Educational Curriculum;Educational process of instructing;Educational workshop;Epidemiology;equity, diversity, and inclusion;Faculty;faculty community;Feasibility Studies;Fostering;Foundations;Funding;Genetic;genome sciences;Genomics;Goals;Grant;Health Disparities Research;health disparity;Hybrids;Impact evaluation;innovation;insight;Intervention;Learning;lectures;Malignant Neoplasms;medical schools;member;Mentors;Mentorship;Minority;Minority Groups;minority investigator;National Human Genome Research Institute;National Institute of General Medical Sciences;novel;people of color;Persons;Play;Population;Positioning Attribute;Postdoctoral Fellow;Productivity;programs;Race;Research;Research Methodology;Research Personnel;Research Project Grants;Research Support;Research Training;response;Role;Science;Series;Services;Site;skills;statistics;Stream;Students;success;Training;Training and Education;undergraduate student;Underrepresented Minority;Universities;university student;virtual

PROJECT_TITLE: Cancer research education program (C-REP)


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunotherapy;Nanotechnology;Natural Products;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The goal of this proposal is to obtain pre-clinical data to enable the translation of a novel nanotechnology-based immunotherapeutic drug to treat triple negative breast cancer that is currently associated with poor prognosis. We use nanotechnology for combination therapy with two drugs in the same nanoparticle allowing drugs to attack cancer cells in a collaborative fashion and produce greater antitumor effect. We will develop validated procedures for manufacturing and analysis of the combination therapeutic and assess its safety, delivery to tumors and efficacy in comparison with the standard therapeutics in animal models that recapitulate human disease.

PI_NAMEs: KABANOV, ALEXANDER V (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Address;Advanced Development;Animal Model;Animals;Anthracycline;Antigens;antitumor effect;Biodistribution;Biological Assay;Breast Cancer Patient;cancer cell;cancer subtypes;Carboplatin;CD2 gene;chemotherapy;Cisplatin;Clinic;Clinical;Clinical Oncology;Combined Modality Therapy;copolymer;Crossover Design;Data;Development;Disease;Dose;Drug Combinations;Drug Delivery Systems;drug development;Drug Kinetics;Excipients;Genetically Engineered Mouse;Goals;good laboratory practice;Good Manufacturing Process;Human;human disease;Hydrophobicity;Immune;Immune checkpoint inhibitor;Immunotherapeutic agent;Immunotherapy;improved;In complete remission;Investigational Therapies;Isogenic transplantation;Lead;Macaca mulatta;Malignant Breast Neoplasm;Malignant Neoplasms;manufacture;Medical;Micelles;Modeling;mouse model;Mus;nanoformulation;nanoparticle;Nanotechnology;nanotherapeutic;Neoadjuvant Therapy;Neoplasm Metastasis;nonhuman primate;novel;novel strategies;Paclitaxel;Pathologic;Patient-Focused Outcomes;Patients;PET/CT scan;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacology;Phase;Phase I/II Trial;Plasma;Platinum;Polymers;Postoperative Period;pre-clinical;Pre-Clinical Model;Procedures;Prodrugs;Prognosis;programs;Rattus;Recurrent disease;Reproducibility;Resources;response;Rodent;Safety;safety assessment;Sampling;small molecule;Solubility;standard of care;Study models;success;synergism;taxane;Taxes;Technology;Testing;Therapeutic;TP53 gene;Translations;Treatment outcome;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;Vertebral column;Visceral metastasis;Work

PROJECT_TITLE: TOWARD TRANSLATION OF NANFORMULATED PACLITAXEL-PLATINUM COMBINATION


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Multiple myeloma (MM) is the most common hematological cancer in African Americans, who experience incidence rates 2-3 times higher than whites for reasons that remain unclear. The goal of this project is to investigate the role of inherited genetic variation involved in regulating gene expression and variation of white blood cell traits in modulating susceptibility to MM in African Americans. Leveraging integrative and innovative methods for incorporating gene expression, genetic ancestry, and somatic tumor features will provide insight into the biology of MM and its racial/ethnic disparity, which may inform new avenues for risk-stratification.

PI_NAMEs: KACHURI, MIRLINDA  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Accounting;Affect;African;African American;African American population;African ancestry;Alternative Splicing;American;anti-cancer research;Awareness;biobank;Biological;Biology;Blood Cells;Bone Marrow;Cancer Control;cancer epidemiology;cancer health disparity;Cancer Research Project;career;causal variant;Cessation of life;Clinical;Clonal Expansion;comparative;Creativeness;Data;design;Development;Diagnosis;Disparity;Environmental Exposure;Epidemiology;ethnic disparity;Ethnic Origin;Etiology;European;European ancestry;Event;experience;Frequencies;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic architecture;Genetic Determinism;genetic epidemiology;genetic predictors;Genetic Predisposition to Disease;Genetic Research;Genetic study;genetic variant;Genetic Variation;genome wide association study;genome-wide;Genomics;Germ Lines;Goals;Health;health equity;Hematologic Neoplasms;Hematology;high risk;Immune;improved;Incidence;Individual;Inherited;innovation;insight;Investigation;Leukocytes;Malignant Neoplasms;Maps;Mendelian randomization;Methods;Multiomic Data;Multiple Myeloma;Mutation;novel;Outcome;Participant;Pathway interactions;Patients;Phenotype;Plasma Cells;Play;polygenic risk score;Population;Positioning Attribute;Precision Health;predictive modeling;Predisposition;Process;programs;Quantitative Trait Loci;Race;racial disparity;Research;Risk;risk stratification;risk variant;Role;skills;Spliced Genes;Survival Rate;Testing;Training;trait;transcriptome;transcriptomics;tumor;tumor heterogeneity;Underrepresented Populations;United States;Variant;White Blood Cell Count procedure;Work

PROJECT_TITLE: Comprehensive Investigation of Multiple Myeloma Genetic Susceptibility in African Americans


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HOUSTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Platinum Talen has the potential to fulfil the unmet need of cell replacement therapy by generating novel genetic models of photoreceptor degeneration that closely resemble human conditions. This application will provide fundamental information on the integration and functional restoration of graft photoreceptors in novel genetic models versus laser-induced models. Importantly, this project has the potential to establish a new platform for testing various cell replacement therapy, which will be invaluable for the ultimate goal of moving the cell replacement therapy into the clinic.

PI_NAMEs: FU, YINGBIN  (contact);IWATA, TAKESHI ;MANDAI, MICHIKO ;SAKUMA, TETSUSHI

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Ablation;Acute;Address;Alleles;autosome;Biological Models;causal variant;cell preparation;cell replacement therapy;Cell Therapy;Clinic;Disease;Disease Progression;early onset;Electroretinography;Evaluation;Eye;functional restoration;fundus imaging;Gene Modified;Generations;Genes;Genetic Models;genome editing;Goals;Histologic;Homologous Gene;Human;human embryonic stem cell;human induced pluripotent stem cells;in vivo imaging;Inherited;Laser injury;Lasers;Leber's amaurosis;Modeling;Monitor;mutant;Natural regeneration;Nature;novel;Optics;Organism;Pathologic;Patients;Phenotype;photoreceptor degeneration;Photoreceptors;Platinum;regenerative cell;Reporting;Retina;Retinal Degeneration;Retinal Diseases;retinal progenitor cell;Retinitis Pigmentosa;Rod;Specificity;Technology;Testing;Therapeutic;Time;tomography;transcription activator-like effector nucleases;Translations;Transplantation;Vertebrate Photoreceptors;Visual impairment;Visual System

PROJECT_TITLE: A two-pronged approach to generating novel models of photoreceptor degeneration for regenerative cell therapy


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Estrogen;Nutrition;Obesity;Physical Activity;Prevention;Women's Health Research

PHR: Project 2 - Project Narrative Weight regain after weight loss remains a major obstacle in the treatment of obesity, although exercise has been shown to help males regain less weight compared to females during relapse. The studies in this proposal will elucidate the biological mechanisms by which exercise exerts beneficial effects during weight relapse and help us understand why men and women respond differently to this treatment. Our observations will identify novel mechanisms and therapeutic strategies to more successfully treat this disorder.

PI_NAMEs: MACLEAN, PAUL S. (contact)

PROJECT_TERMS: Acylation;Adipose tissue;Appetite Regulation;Attenuated;Back;Bioenergetics;Biological;Body Weight;Body Weight Changes;Body Weight decreased;cardiometabolism;Collaborations;cost;cytokine;Darkness;Deposition;Desire for food;Diet;Dietary Fats;Disease;Eating;Eating Behavior;energy balance;Energy Intake;Energy Metabolism;Estradiol;Estrogens;Exercise;exercise training;Exhibits;experience;Fatty acid glycerol esters;feeding;Female;Foundations;ghrelin;glucagon-like peptide 1;gonad function;Hormones;Injections;insight;Intake;Kynurenine;life span;Light;Link;lipid biosynthesis;Lipids;Liver;Maintenance;male;Mediating;men;Menopause;Metabolism;Molecular Profiling;Muscle;neural;novel;Obesity;obesity treatment;Observational Study;Ovarian;Ovariectomy;overweight adults;oxidation;Pancreas;Pathway interactions;peptide hormone;Peptide YY;Physiological;pre-clinical;Pre-Clinical Model;prevent;Punch Biopsy;Rattus;Regulation;Relapse;response;Role;sedentary;sex;Sex Differences;sexual dimorphism;Testing;Therapeutic;Tissues;Tracer;transcriptome sequencing;Tryptophan;Weight;Weight Gain;Weight maintenance regimen;Woman;Women's Health

PROJECT_TITLE: Intersection of Exercise and Estrogen in Weight Regain After Weight Loss


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative  Drosophila, with its genetic amenability and small brain size, yet sophisticated behavior, is a powerful model system to study how photoreceptor neurons that are stochastically specified communicate their decision to their downstream targets to propagate their specific sensory information. Activity-dependent neural patterning is another powerful mean to coordinate patterning of different brain regions and we will study how waves of activity that we observe at a very specific time point during retinal development are generated and what role they play. The principles deduced from this project will be applicable to other neural systems in more complex organisms.

PI_NAMEs: DESPLAN, CLAUDE  (contact)

PROJECT_TERMS: Address;Antigen-Presenting Cells;Apoptotic;Axon;Behavior;Biological Models;Brain;Brain region;brain size;Calcium;Calcium Oscillations;Cell Adhesion;Cell Adhesion Molecules;cell type;Cells;Cessation of life;Color;Color Visions;Communication;Complex;connectome;Connexins;Data;Development;Drosophila genus;Embryo;Event;Evolution;experience;Family;fly;Gap Junctions;Genetic;Human;Knowledge;Mediating;Molecular;Molecular Genetics;mRNA sequencing;neural;neural patterning;Neurons;Optic Lobe;Organism;Pathway interactions;Pattern;Photoreceptors;Play;Postdoctoral Fellow;Process;programs;Proteins;Retina;Retinal Cone;Role;Sensory;sensory input;Sensory Process;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;Specificity;Synapses;synaptogenesis;System;Testing;Time;tool;transcriptome;transmission process;Visual Pathways;Visual System

PROJECT_TITLE: Coordinated patterning of brain regions

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Genetics

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative tRNAs are small noncoding conserved RNAs that are essential for decoding the genome and regulating the proteome in response to nutrient availability and stress. Thus, mutations of genes involved in tRNA biology cause human disorders ranging from metabolic diseases, to neuromuscular diseases, and to cancer. We employ the powerful budding yeast model system and genetics, genomics, microscopy, molecular, and biochemical in vivo technologies to resolve key unknowns regarding tRNA biology including nuclear/cytoplasmic bidirectional trafficking, quality control, RNA processing, and intron turnover/function.

PI_NAMEs: HOPPER, ANITA K (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Adaptor Signaling Protein;Address;Affect;Amino Acids;Aniline;Apoptosis Regulation Gene;Archaea;Back;base;Biochemical;Biological;Biological Assay;Biological Process;Biology;Cell Nucleus;cell preparation;Cells;Code;Codon Nucleotides;Complex;crosslink;Cytoplasm;Data;Dedications;Defect;Disease;Equilibrium;Eukaryotic Cell;Excision;Explosion;Exportins;Family;Formaldehyde;gene conservation;Gene Expression;Gene Mutation;gene product;Genes;Genetic;Genetic study;Genetic Transcription;Genome;genome wide screen;Genomics;Growth;Health;Human;human disease;Importins;in vivo;Individual;Introns;Knowledge;Learning;Licensing;Malignant Neoplasms;Messenger RNA;Metabolic Diseases;Methodology;Microscopy;Modification;Molecular;Movement;mRNA Stability;mutant;Neuromuscular Diseases;novel;Nuclear;Nuclear Export;Nuclear Import;Nuclear Protein;nuclease;Nutrient availability;Organism;overexpression;Pathway interactions;Phenylalanine-Specific tRNA;Play;posttranscriptional;preference;Procedures;Process;programs;Proteins;Proteome;Quality Control;Regulation;Regulator Genes;Reporting;Research;Research Project Summaries;response;Ribosomes;RNA;RNA Processing;RNA Splicing;Role;Saccharomycetales;Signal Transduction;Specific qualifier value;Specificity;Stress;Stretching;Technology;Testing;Time;trafficking;Transfer RNA;Translating;translational engagement;Translational Regulation;Translations;Travel;tRNA Precursor;Untranslated RNA;Vertebrates;Yeast Model System;Yeasts

PROJECT_TITLE: tRNA processing and nuclear-cytoplasmic dynamics

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: PROJECT NARRATIVE The research outlined in this proposal will determine the molecular factors shaping intrinsically photosensitive retinal ganglion cell (ipRGC) subtype identity. ipRGC subtypes differ in their morphological, physiological, and molecular properties, and many of these defining features correlate with expression levels of the transcription factor Brn3b. Therefore, this study will determine how the patterning of Brn3b shapes ipRGC subtype identity. Our findings will provide a blueprint for understanding how transcription factors involved in early specification are repurposed to drive the development of multiple features of cellular structure and function.

PI_NAMEs: SCHMIDT, TIFFANY M. (contact);YANG, YUE

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Adult;Behavior;Brain;Cell Physiology;cell type;Cells;Cellular Morphology;Cellular Structures;Characteristics;Complement;Data;Development;Embryonic Development;experimental study;Eye;ganglion cell;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;genetic approach;Genetic Models;Genetic Transcription;Genomics;Goals;Individual;insight;Label;Light;Location;Measurement;melanopsin;Methods;Molecular;Morphology;Mus;Nervous System;Neurons;novel;Organism;overexpression;patch clamp;Pattern;Photoreceptors;Physiological;Physiology;Population;postmitotic;programs;Property;Research;Resolution;Retina;Retinal Ganglion Cells;Role;Shapes;single nucleus RNA-sequencing;single-cell RNA sequencing;Specific qualifier value;Structure;System;Testing;tool;transcription factor;Transcription Factor Brn-3B;Transcriptional Regulation;transcriptome;transcriptomics

PROJECT_TITLE: Genetic Underpinnings of ipRGC Diversity

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Aging;Estrogen;Menopause;Nutrition;Obesity;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

PHR: Menopause is an unavoidable aging-related event in women that is accompanied by increased belly fat and fat-related disease, but the causes remain uncertain. This project will investigate how a rare type of fat cell produced from blood stem cells contributes to increases in body weight. Successful completion of these studies will identify new ways to modify the production of these cells as potential treatments for menopausal metabolic disorders.

PI_NAMEs: KLEMM, DWIGHT J (contact)

PROJECT_TERMS: abdominal fat;Ablation;Adipocytes;Adipose tissue;Adoptive Transfer;Aging;aging related;Amino Acids;Aryl Hydrocarbon Receptor;Bioenergetics;Blood Vessels;Body fat;Body Weight;Bone Marrow;Brain;cardiometabolism;Cells;Cellularity;Centers of Research Excellence;Collaborations;Colorado;comorbidity;Data;diet-induced obesity;Dioxygenases;Disease;Electrons;Energy Metabolism;Enzymes;ESR1 gene;Estrogen Replacements;Estrogens;Event;Fatty acid glycerol esters;Female;Funding;Genetic;gonad function;Gonadal Steroid Hormones;Health;Hematopoietic;Hematopoietic Cell Production;Hematopoietic stem cells;High Fat Diet;HIV;Human;immunoregulation;Incidence;indoleamine;Inflammation;Insulin Resistance;knock-down;Knockout Mice;Kynurenic Acid;Kynurenine;Laboratories;Leptin;Liver;lymphocyte proliferation;male;Menopause;Mesenchymal;Mesenchymal Stem Cells;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Metabolism;Mus;Myelogenous;Names;Nicotinamide adenine dinucleotide;novel;Obesity;Ovariectomy;Pathway interactions;Patients;Perimenopause;Phenotype;Physical activity;Physiological;Play;Population;Postmenopause;Premenopause;prevent;Production;Regulation;Relaxation;response;Rheumatism;Role;Sex Differences;Signal Transduction;Skeletal Muscle;Specialized Center;subcutaneous;System;systemic inflammatory response;T-Lymphocyte;Testing;Tryptophan;Tryptophan 2,3 Dioxygenase;Universities;Visceral;Weight Gain;western diet;Woman

PROJECT_TITLE: Suppression of ERalpha in Hematopoietic Stem Cell-Derived Adipocytes Increases Adiposity via Kynurenine and the Aryl Hydrocarbon Receptor


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Digestive Diseases;Gene Therapy;Genetics;Liver Disease;Nanotechnology;Women's Health Research

ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative RNAi molecules can be designed against conventionally-undruggable, tumor-driving genes, but siRNA use in clinical oncology faces delivery barriers such as nuclease degradation, rapid renal clearance, poor distribution into tumor tissues, and poor cell membrane penetration. The overarching goal of this project is to develop siRNA chemical modifications that provide potent, safe, tumor-penetrating, and molecularly-targeted nano- therapeutics against currently undruggable tumor drivers. This approach will specifically yield siRNAs that form nano-complexes with albumin in situ following intravenous injection and will be developed to target the anti- apoptotic tumor driver Mcl-1 to treat triple negative breast cancer.

PI_NAMEs: COOK, REBECCA SARA;DUVALL, CRAIG LEWIS (contact);UDDIN, MD JASHIM;VICKERS, KASEY C

PROJECT_TERMS: Abraxane;Address;Albumins;Allografting;Apoptosis;Apoptotic;Automobile Driving;Basic Science;Benchmarking;Binding;Biodistribution;Biological;Biomedical Engineering;BRCA1 gene;Breast Cancer Model;Breast Cancer Patient;Breast Cancer therapy;c-myc Genes;cancer clinical trial;cancer subtypes;Cell membrane;Cells;chemical synthesis;Chemicals;Chemistry;chemotherapy;Cholesterol;Clinical;Clinical Oncology;clinical translation;Consultations;cooking;design;Development;Dose;Doxorubicin Hydrochloride Liposome;Drug Delivery Systems;Drug Formulations;Drug Kinetics;endosome membrane;Endosomes;ethylene glycol;Extrahepatic;Face;FDA approved;Formulation;Gene Silencing;Genes;Genome;Goals;Hepatic;Hepatocyte;Human;Immunocompetent;improved;In Situ;In Vitro;in vitro activity;in vivo;inhibitor;Injections;interest;intravenous injection;Investigation;Investigational Therapies;knock-down;lead candidate;Lipid Binding;lipid nanoparticle;Lipids;Liver;Liver neoplasms;Luciferases;Malignant Breast Neoplasm;Malignant Neoplasms;MCL1 gene;Measures;Medical Oncologist;Modeling;Modification;Molecular Target;molecular targeted therapies;Mus;mutant;nano;nanocomplexes;nanoformulation;nanomedicine;nanopolymer;Nanotechnology;nanotherapeutic;nuclease;Oligonucleotides;Oncogenes;Organ;orthotopic breast cancer;Pathway interactions;patient derived xenograft model;Penetrance;Penetration;Permeability;Pharmaceutical Preparations;Pharmacologic Substance;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;pre-clinical;Pre-Clinical Model;Property;Publishing;Renal clearance function;response;RNA Interference;RNA Interference Therapy;RNA Transport;Safety;screening;Serum;Serum Albumin;Serum Proteins;siRNA delivery;Site;Small Interfering RNA;small molecule;small molecule inhibitor;spheroids;success;taxane;Technology;Testing;theories;Therapeutic;therapeutic siRNA;Toxic effect;Toxicology;Transgenic Organisms;Treatment Efficacy;triple-negative invasive breast carcinoma;Tropism;tumor;Tumor Tissue;tumor xenograft;Untranslated RNA;Work;Xenograft procedure

PROJECT_TITLE: In Situ Albumin Binding siRNAs for Triple Negative Breast Cancer Tumor Penetration and Molecularly Targeted Therapy

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emergency Care;Heart Disease

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative The Hospital Airway Resuscitation Trial (HART) is a Phase II/III, cluster-randomized with crossover pragmatic trial comparing advanced airway management with a strategy of endotracheal intubation or supraglottic airway during cardiopulmonary resuscitation of in-hospital cardiac arrest victims. Patients who suffer a cardiac arrest in the hospital will be included, and we will compare the number of alive-and-ventilator free days between groups in addition to a number of other secondary and mechanistic outcomes. We hypothesize that a strategy of first-choice supraglottic airway will result in more alive-and-ventilator-free days than a strategy of endotracheal intubation in a cohort of patients suffering in-hospital cardiac arrest.

PI_NAMEs: MOSKOWITZ, ARI  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Acute;Address;Adult;American Heart Association;Cardiac;Cardiopulmonary Resuscitation;cardiovascular emergency;Caring;Chest;Circulation;Clinical;clinical infrastructure;Cluster randomized trial;cohort;Community Hospitals;comorbidity;Complex;Critical Care;Critical Illness;Cross-Over Studies;Cross-Over Trials;Data;Defibrillators;Devices;Effectiveness;Electric Countershock;Electronic Health Record;electronic structure;Elements;endotracheal;Enrollment;Epinephrine;Esophageal injury;Event;evidence base;first responder;functional outcomes;functional status;Guidelines;Health system;Heart Arrest;Hospitalization;Hospitals;Hour;improved;Infrastructure;innovation;Inpatients;Interruption;Intervention;Intratracheal Intubation;Intubation;Knowledge;Laryngoscopy;Life;Measures;Medical;Modality;Monitor;Morbidity - disease rate;mortality;Neurological outcome;New York City;Observational Study;out-of-hospital cardiac arrest;Outcome;patient population;Patient-Focused Outcomes;Patients;Pharyngeal structure;Phase;Pneumothorax;Population;pragmatic randomized trial;pragmatic trial;primary outcome;Procedures;Pulmonary aspiration of gastric contents;Randomized;randomized trial;Recommendation;Research Infrastructure;response;Resuscitation;secondary outcome;Site;Societies;success;System;Time;trial comparing;Tube;United States;Ventilator;vocal cord

PROJECT_TITLE: Hospital  Airway Resuscitation Trial

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE: OVERALL The well-established Meharry Medical College/Vanderbilt-Ingram Cancer Center/Tennessee State University Cancer Partnership (MVTCP) triad provides an exceptional environment to identify and address health care inequities in cancer seen in underrepresented minorities. The proposed research projects, cores, and shared resource cores will grow research and propose evidence-based solutions address to these inequities. Further, the development of expanded research infrastructure at MMC and TSU, enhancement of minority education programs, and improvement to the effectiveness of cancer-related activities will address health care disparities in the greater Nashville geographical region, with the ultimate goal of contributing to reducing health disparities among cancer patients in minority and underserved communities.

PI_NAMEs: PAL, TUYA  (contact);WINKFIELD, KAREN MARIE

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Address;anti-cancer research;Area;Award;Awareness;Basic Science;Behavioral;Big Data;Bioinformatics;Bioinformatics Shared Resource;Biological Factors;Biometry;Cancer Center;cancer clinical trial;cancer health disparity;cancer initiation;Cancer Patient;Cancer Research Project;career;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;collaborative approach;Colorectal Cancer;Communities;Community Health;community organizations;community research;Comprehensive Cancer Center;Death Rate;Development;Discipline;Disparity;Education;education research;Effectiveness;Environment;Equity;Ethnic Origin;Evaluation;evidence base;Extramural Activities;Faculty;Financial Hardship;Fostering;Geographic Locations;Geography;Goals;graduate student;Growth;health care disparity;Health Educators;high school;Immunooncology;improved;Incidence;Inequity;Infrastructure;Institution;Intervention Trial;Lead;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;Medical Students;Minority;minority communities;Minority-Serving Institution;Mission;mortality;multidisciplinary;Oncology;Outcome;outcome disparities;outreach;outreach program;Pathology;Pathway interactions;Patient Participation;Peer Review;Population Research;Population Sciences;Prevalence;programs;Publications;Race;recruit;Reduce health disparities;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resource Sharing;screening;Series;socioeconomics;survivorship;Tennessee;Training;Translational Research;treatment trial;undergraduate student;Underrepresented Minority;underserved community;United States;Universities

PROJECT_TITLE: (2/3) MMC, VICC, and TSU: Partners in Eliminating Cancer Disparities


NIH_SPENDING_CATS: Aging;Women's Health Research

PHR: The decline in sex hormones (estrogen and testosterone) with aging can increase risk for certain diseases; osteoporosis is a well-known example. This is particularly important for women’s health because the loss of estrogen occurs during mid-life, whereas the loss of testosterone in men occurs much later in life. The Colorado Specialized Center of Research Excellence on Sex Differences (SCORE) will advance novel ideas for how the loss of estrogen increases fat gain in the abdominal region, which increases risk for heart disease and diabetes, and strategies that may be effective in preventing this.

PI_NAMEs: KOHRT, WENDY M (contact)

PROJECT_TERMS: 3-Dimensional;Abdomen;abdominal fat;Address;Administrator;age-related disease;Aging;Area;Attention;Award;Bioenergetics;cardiometabolism;career;career development;Centers of Research Excellence;Clinical Sciences;clinical translation;Collaborations;Colorado;data management;Decision Making;Diabetes Mellitus;Disease;distinguished professor;Doctor of Philosophy;Education;Endocrinology;Ensure;Estrogens;Evaluation;experience;Faculty;Family;Fatty acid glycerol esters;Financial Support;Fostering;Functional disorder;Generations;Geriatrics;Goals;gonad function;Gonadal Steroid Hormones;Grant;heart disease risk;Homeostasis;Institution;Interdisciplinary Study;Knowledge;Leadership;Life;Medical;Medicine;member;men;Mentored Clinical Scientist Development Program;Mentors;Metabolism;middle age;multidisciplinary;Names;novel;nutrition;Obesity;organizational structure;Osteoporosis;Ovarian;Pilot Projects;Positioning Attribute;prevent;Productivity;professor;programs;Regulation;Research;Research Personnel;Research Project Grants;Resource Allocation;Risk;Role;Schedule;Scientist;Sex Differences;Specialized Center;Testosterone;TNFSF15 gene;Training;Training Activity;translational pipeline;Translational Research;Universities;Wit;Women's Health

PROJECT_TITLE: Leadership & Administration Core


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: PAL, TUYA  (contact)

PROJECT_TERMS: Advisory Committees;Annual Reports;anti-cancer research;Basic Science;Belief;Cancer Center;cancer health disparity;career development;Clinical;Clinical Sciences;Collaborations;Communication;Community Outreach;Data;Disparity;Doctor of Philosophy;Educational workshop;Ensure;Ethnic Origin;Evaluation;Expenditure;experience;Faculty;faculty mentor;Faculty Recruitment;Fostering;Funding;Funding Agency;Funding Opportunities;Geography;Goals;Growth and Development function;Guidelines;Human Resources;implementation strategy;Infrastructure;innovation;Institution;Leadership;Malignant Neoplasms;medical schools;Mentorship;Mission;Monitor;National Cancer Institute;Occupational activity of managing finances;Office of Administrative Management;Phase;Population Sciences;Preparation;Principal Investigator;Process;Productivity;programs;Progress Reports;Race;recruit;Regulation;Reporting;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Resource Sharing;Resources;responsible research conduct;Services;Socioeconomic Status;Strategic vision;symposium;synergism;Tennessee;Training and Education;United States National Institutes of Health;Universities;Vision;Work


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Persons on maintenance hemodialysis are at high-risk of hospital-acquired infections, yet there is a tremendous paucity of data pertaining to the epidemiology of hospital-acquired infections in this patient population. In this proposal, we will use the United States Renal Data System database in addition to active surveillance methodology to fully characterize the epidemiology of hospital-acquired infections, including prevalence, risk factors, outcomes and causative pathogens and their antimicrobial resistance profiles, among persons on maintenance hemodialysis. An increased understanding of hospital-acquired infection epidemiology among this high-risk group will provide important information to guide current and future prevention strategies aimed at reducing hospital-acquired infections and improving patient outcomes.

PI_NAMEs: D'AGATA, ERIKA M (contact)

PROGRAM_OFFICER_NAME: HENDERSON, SUSAN

PROJECT_TITLE: The INFECTADO study: INFECTions Acquired by persons on maintenance hemoDialysis during hOspitalizations

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]