ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Narrative: Epilepsy is characterized by recurrent seizures and is frequently resistant to antiepileptic drugs. This new proposal focusses on the design of a novel neurotechnology to control seizures based on the new finding that the neuro electric field plays a crucial role in the generation propagation of seizures electric field coupling.

PI_NAMEs: DURAND, DOMINIQUE M (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acute;alternative treatment;anti-epileptic agents;Brain;Characteristics;Chronic;Closure by clamp;Communication;Computer Models;Computer Simulation;Coupling;Data;design;efficacy testing;electric field;Electrodes;Electrophysiology (science);Epilepsy;experimental study;extracellular;Extracellular Space;Focal Seizure;Furosemide;Generations;Goals;Hippocampus;Human;Image;In Vitro;in vivo;Iron;Kainic Acid;Laboratories;Mediating;Membrane;Methodology;Methods;Modeling;Nerve Block;neural;neuroimaging;Neurons;neurotechnology;new technology;novel;novel strategies;novel therapeutics;optogenetics;Osmolar Concentration;Partial Epilepsies;Patients;Pharmaceutical Preparations;Play;Preparation;prevent;recruit;Recurrence;Research;Resistance;Rodent;Role;Seizures;System;Techniques;Technology;Temporal Lobe Epilepsy;Testing;Tissues;Travel;Treatment Efficacy;voltage;voltage clamp

PROJECT_TITLE: Seizure control by electric field control


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Complementary and Integrative Health;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Neurosciences;Substance Misuse

ORG_CITY: CAMBRIDGE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: The research plan we propose aims at a comprehensive multi-level understanding of how the brain and the body interact to respond adaptively to a potentially harsh and unforgiving environment. Among the many internal factors that are under constant homeostatic regulation, we focus on the bi-directional dialogue between the brain and the heart, since the cardiovascular system and its role in regulating oxygen delivery is one of the most critical and universal control systems within the animal kingdom. A central aspect of our approach is the generation of a complete brain and body connectome of the larval zebrafish, a map which will be the first ever generated in a vertebrate, and which will be critical in both testing the validity of many extant models, and perhaps discovering new pathways within the interconnected neural circuits that serve the changing needs of the body during behavior.

PI_NAMEs: LICHTMAN, JEFF W (contact)

PROJECT_TERMS: analytical tool;Animals;automated segmentation;Axon;Behavior;Behavioral;Biological Models;Brain;Cardiovascular system;Cells;Characteristics;Code;Collaborations;connectome;Consumption;Coupled;Data;Data Set;Dimensions;Education and Outreach;Electron Microscopy;Environment;excitatory neuron;experience;Extracellular Space;Fishes;Fluorescence Microscopy;Generations;Goals;Grant;Heart;Human;Illusions;Image;image processing;improved;Infrastructure;interest;Label;Learning;light microscopy;Machine Learning;Manuals;Maps;Methods;microscopic imaging;millimeter;Mind;mind body interaction;Mission;Modeling;Modernization;Modification;Molecular;Morphologic artifacts;Motor;Motor output;nanoscale;natural language;Nervous System;neural;neural circuit;Neural Interconnection;neuronal patterning;Neurons;Organ;Output;Oxygen;Pathway interactions;Phase;Physics;postsynaptic;presynaptic;Process;psychobiology;query tools;Regulation;Research;Research Personnel;Resolution;Role;sample fixation;Scanning Electron Microscopy;Sensory;sensory input;Series;Signal Transduction;Speed;Stains;Structure;Synapses;System;Techniques;Technology;Testing;Time;Tissues;tool;two photon microscopy;Vertebrates;Zebrafish

PROJECT_TITLE: EM CORE


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PITTSBURGH

ORG_DEPT: CHEMISTRY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative Halide-containing nucleosides and nucleotides represent an important family of synthetic drugs for anticancer and antiviral treatments, thus it is essential to develop novel and effective synthetic strategies to expand halogenated nucleoside/nucleotide compound library for drug discovery. Radical halogenation via carbon- hydrogen bond activation catalyzed by iron and 2-oxoglutarate (Fe/2OG) dependent enzymes represents an attractive strategy to install carbon-halide bonds in a regio- and stereo-specific fashion. In this projects, two newly discovered Fe/2OG enzymes that catalyze radical halogenation to generate halide-containing nucleotide natural products and amino acids will be mechanistically investigated, the obtained mechanistic insights will be further deployed to develop these enzymes into biosynthetic platform to access new halide-containing nucleotide/nucelosides.

PI_NAMEs: GUO, YISONG  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Dissect Mechanism of Iron(II)/2-Oxoglutarate Dependent Enzymes Catalyzed Halogenation in Nucleotide Biosynthesis

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Complementary and Integrative Health;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PROJECT_TERMS: Animals;Behavior;Behavioral;Brain;Calcium;Cardiovascular system;Computer software;connectome;cost effective;cost effectiveness;Custom;data acquisition;Data Analyses;Dedications;design;design and construction;Devices;Electron Microscopy;Electrophysiology (science);Engineering;Environment;Equipment;experimental study;Generations;Goals;Heart;Image;instrumentation;Laboratories;machine vision;Maps;meetings;member;Microscope;microscopic imaging;millimeter;Mind;mind body interaction;Modeling;Movement;neural;neural circuit;Neural Interconnection;Neurosciences;Neurosciences Research;novel;Optics;Oxygen;Pathway interactions;Postdoctoral Fellow;prototype;Regulation;Reproducibility;Research;Role;Savings;Science;Scientist;Stretching;student training;Students;Swimming;System;Technology;Testing;Training;Training and Education;two-photon;United States National Institutes of Health;Zebrafish

PROJECT_TITLE: Engineering Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Complementary and Integrative Health;Drug Abuse (NIDA only);Neurosciences;Pediatric;Substance Misuse

PI_NAMEs: PETKOVA, MARIELA DIMITROVA (contact)

PROJECT_TERMS: Active Learning;Animals;Behavior;Biological Sciences;Brain;Cardiovascular system;career;career development;citizen science;Communication;Communities;connectome;Dedications;design;Education;Education and Outreach;Educational process of instructing;Educational workshop;Environment;Event;experience;Face;Fellowship;Fellowship Program;Fire - disasters;Future;Future Generations;General Population;Generations;graduate student;Heart;high school;High School Student;Historically Black Colleges and Universities;Hour;Individual;Internships;Knowledge;Laboratories;laboratory experience;Maps;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Middle School Student;Mind;mind body interaction;Mission;model organism;Modeling;Nervous System;neural circuit;Neural Interconnection;Neurosciences;Neurosciences Research;outreach;outreach program;Oxygen;Pathway interactions;pedagogy;Postbaccalaureate;Postdoctoral Fellow;programs;Property;Public Speaking;Publications;recruit;Regulation;Research;Research Project Grants;Role;Schools;Science;Science, Technology, Engineering and Mathematics Education;Scientist;Shapes;skills;Structure;student participation;Students;summer program;System;teacher;Technical Expertise;Technology;Testing;Training;Training and Education;Training Programs;undergraduate student;Underrepresented Students;university student;Work;Zebrafish

PROJECT_TITLE: The Training and Outreach Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Cardiovascular;Complementary and Integrative Health;Drug Abuse (NIDA only);Heart Disease;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

PI_NAMEs: FISHMAN, MARK C (contact)

PROJECT_TERMS: Adult;Affect;Algorithms;Animal Behavior;Animal Model;Animals;Behavior;Behavioral;Behavioral Assay;Behavioral Model;Behavioral Paradigm;Biological Assay;Brain;Cardiac;Cardiovascular system;Complex;Computational algorithm;connectome;Crowding;Decision Making;Desiccation;design;Environment;environmental change;experimental study;Exposure to;Face;Fishes;fitness;Frequencies;Frustration;Generations;Goals;Hair Cells;Hand;Heart;Heart Rate;Home;Homeostasis;Hypoxia;Laboratories;Larva;lateral line;Life;Light;Maps;Measurement;Mind;mind body interaction;Modality;Modeling;Monitor;Motion;Motor;motor behavior;Motor output;Movement;multimodality;multisensory;Nature;neural;neural circuit;Neural Interconnection;Neurons;Oral cavity;Output;Oxygen;Pathway interactions;Pattern;Pectoral;Performance;Phase;Physiological;Play;Preparation;prevent;Proxy;Reflex action;Regulation;Research;Resolution;respiratory;response;Role;sensorimotor system;Sensory;sensory input;sensory integration;Series;Signal Transduction;Sodium Chloride;somatosensory;Statistical Models;Stimulus;Swimming;System;Testing;Time;Update;Variant;Vertebrates;virtual reality;virtual reality environment;Water;Zebrafish

PROJECT_TITLE: A day in the life of a larval zebrafish. Characterization and Modeling of Behavioral Dynamics and Interoceptive Homeostasis


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Genetics

ORG_CITY: Los Angeles

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative  Gene clusters are widespread in genomes but mechanistic understanding of their within-cluster chromatin looping and among-cluster crosstalk is unclear. This study aims to illustrate a stepwise chromatin-protein cas- cade that spatially organizes complex gene clusters from a two-dimensional DNA sequence to a three-dimen- sional subnuclear structure.

PI_NAMEs: LIANG, YA-CHEN  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 3-Dimensional;Biological;Birds;Cell Nucleus;Chromatin Loop;chromatin protein;Chromosome Mapping;Chromosomes;Complex;Development;Disease;DNA Sequence;Epigenetic Process;Gene Cluster;Gene Expression Regulation;Gene Family;Gene Order;Gene Structure;Genes;Genetic Transcription;Genome;Genomics;Globin;Heterogeneity;Homeostasis;Homologous Gene;Human;insight;Keratin;Knowledge;Molecular;Molecular Conformation;Morphogenesis;Mus;Mutation;novel;olfactory receptor;Organ;Outcome;Pattern;Proteins;Regulation;Research;skin organogenesis;Structure;Tissues;Transcriptional Regulation;two-dimensional

PROJECT_TITLE: Intra- and inter-cluster regulations of multiplex gene clusters

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Cardiovascular;Complementary and Integrative Health;Drug Abuse (NIDA only);Heart Disease;Neurosciences;Substance Misuse

PI_NAMEs: ENGERT, FLORIAN  (contact)

PROJECT_TERMS: Affect;Algorithms;Anatomy;Animals;Area;Autonomic ganglion;Autonomic nervous system;Behavior;Behavioral;Behavioral Assay;Behavioral Model;Biological Assay;Brain;Calcium;Cardiac;Cardiovascular system;Competence;Computational algorithm;connectome;Data;data modeling;Data Set;design;Electrophysiology (science);Environment;experimental study;Family;Fishes;Generations;Gills;Goals;Grant;Heart;Hypothalamic structure;Image;Imaging technology;in vivo;Individual;Knowledge;Laboratories;Maps;Measurement;Measures;member;Membrane;Mind;mind body interaction;Modeling;Motor;Motor output;Nature;Nervous System;neural;neural circuit;Neural Interconnection;neural model;Neurons;neuroregulation;novel;optogenetics;Output;Oxygen;patch clamp;Pathway interactions;Pattern;Performance;Physiological;Play;Population;Preparation;Process;Quality Control;reconstruction;Regulation;Research;respiratory;response;Role;Sensorimotor functions;sensory input;sensory stimulus;simulation environment;statistics;Synapses;System;Technology;Testing;Transgenic Organisms;Validation;virtual;Visualization;Weight;Zebrafish

PROJECT_TITLE: What is going on in the fish's brain?   Characterization and Modeling of Neural Dynamics  (CNS and ANS and ICNS)


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: The goal of the Cleveland Open Source Modular Implant Innovators Community (COSMIIC) is to establish an implanted electrical stimulation system that can be used for treatment of diseases, particularly in the peripheral nerves. All of the plans and instructions necessary to create this implanted system will be made available freely to the research community so that everyone can benefit. We hope that this will quickly advance the treatment of many diseases.

PI_NAMEs: CHESTEK, CYNTHIA ANNE;KILGORE, KEVIN L. (contact);SMITH, BRIAN

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-M(50)R]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

PI_NAMEs: KILGORE, KEVIN L. (contact)

PROJECT_TERMS: Adoption;Agreement;Apidae;Applications Grants;Area;Arrhythmia;Autonomic nervous system;bioelectricity;bioelectronics;Bladder;Blood Vessels;Body System;Brain;Budgets;California;CBL gene;Cerebral Palsy;Charge;Clinic;clinical application;Clinical Trials;Communication;Communities;Congestive Heart Failure;Data;design;Devices;Diabetes Mellitus;disability;Disease;Documentation;Education;Electrodes;Electronics;Endocrine;Engineering;Ensure;Ethics;Family;Feedback;first-in-human;Foundations;Funding;Goals;Grant;Healthcare Systems;Heart;Heart Atrium;Human;Hypertension;Implant;implant design;implantable device;Incontinence;innovation;Institution;interest;Intestines;Label;Los Angeles;Macular degeneration;manufacture;Marketing;Medical;meetings;Menopause;Michigan;Monitor;Motor;Myocardial Infarction;Names;Nerve Pain;neural;neuroregulation;novel;Obesity;Ohio;online community;open source;operation;Pain;patient population;pelvic organ prolapse;Peripheral Nerves;Persons;Process;Property;recruit;Research;Resources;Retina;Retinitis Pigmentosa;Running;Schedule;Scientist;Sex Functioning;Skeletal Muscle;spasticity;Specific qualifier value;Spinal Cord;spinal cord and brain injury;Spinal cord injury;Spinal Ganglia;Stomach;Stroke;Synapses;System;Technology;Testing;Universities;web site

PROJECT_TITLE: Beekeeper Administrative Core for COSMIIC HORNET

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-M]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Complementary and Integrative Health;Drug Abuse (NIDA only);Heart Disease;Machine Learning and Artificial Intelligence;Neurosciences;Substance Misuse

PROJECT_TERMS: Animals;Atlases;automated segmentation;Autonomic nervous system;Autonomic Pathways;Behavior;Behavior Therapy;Behavioral;Blood Vessels;Brain;Cardiac;Cardiovascular system;cell type;Cells;Central Nervous System;Computer Assisted;computer science;connectome;connectome data;Data;Desire for food;Electron Microscopy;Environment;Event;experimental study;Fishes;Futility;Generations;Gills;Goals;Hand;Heart;high resolution imaging;Image;Infrastructure;interest;light microscopy;Limb structure;Link;Location;Machine Learning;Manuals;Maps;Methods;Mind;mind body interaction;Modeling;Motor;Motor Pathways;Muscle;Nervous System;neural;neural circuit;Neural Interconnection;Neural Pathways;Neurons;Organ;Output;Oxygen;Pathway interactions;Peripheral;Peripheral Nervous System;Publishing;reconstruction;Reflex action;Regulation;Research;Research Personnel;Resolution;Role;Sensory;skeletal;skills;Synapses;System;Testing;Time;tool;usability;Validation;Vascular blood supply;Vertebrates;Zebrafish

PROJECT_TITLE: Zooming into the fish's brain-What is really going on!  Connectomics analysis of larval zebrafish.


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Precision Medicine;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: DAVIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Child psychotic-like experiences (PLEs) are common disturbances of perception and ideation that occur in childhood and that (if they become persistent) may be risk factors for poor mental health in adolescence and beyond. As risk factors that predict persistent PLEs have not been reliably identified, the goal of this study is to use deep learning combined with explainable artificial intelligence to identify features from multimodal data in the Adolescent Brain and Cognitive Development Study dataset that predict future levels of PLE distress, and then use these features to model PLE trajectories using structured equation modeling. The results of this study will help develop novel, personalized ways to prevent persistent PLEs from developing and ultimately improve mental health.

PI_NAMEs: SMUCNY, JASON  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adolescence;Adolescent;adverse outcome;Affect;Age;Algorithms;Behavior;Black Box;Brain;California;career;career development;Child;Childhood;Classification;Clinical;clinical predictors;Cognition;cognitive development;cohort;Computing Methodologies;Data;Data Set;Decision Making;deep learning;deep learning algorithm;demographics;Development;Device or Instrument Development;Diagnostic;diagnostic tool;Diffusion Magnetic Resonance Imaging;Disease remission;Distress;DSM-III;Early Intervention;Education;Educational workshop;Environment;environmental stressor;Equation;Event;experience;explainable artificial intelligence;Exposure to;Faculty;Family;Family history of;follow-up;Functional Magnetic Resonance Imaging;Future;Goals;Grant;gray matter;ideation;improved;individualized medicine;individualized prevention;Influentials;innovation;insight;Interview;Laboratories;Learning;Machine Learning;Manic;Measurement;Measures;meetings;Mental disorders;Mental Health;Mentors;Methods;Modeling;multimodal data;multimodality;National Institute of Mental Health;Neurocognitive;neurocognitive test;neuroimaging;novel;novel diagnostics;Nutritional;Output;Patient Self-Report;Perceptual disturbance;personalized intervention;personalized medicine;Phenotype;Positioning Attribute;Postdoctoral Fellow;Predictive Factor;predictive marker;prevent;Prevention strategy;programs;Psychiatrist;Psychiatry;Psychopathology;Psychoses;psychotic-like experiences;Questionnaires;Recommendation;Recording of previous events;Research;Research Assistant;Research Personnel;Research Project Grants;Rest;Risk;Risk Factors;Risk Reduction;Schedule;Secure;Severities;skills;Societies;socioeconomics;statistics;Structure;Substance abuse problem;Suicide attempt;Sum;Testing;Time;tool;Training;trustworthiness;tv watching;United States National Institutes of Health;Universities;Vocational Guidance;white matter

PROJECT_TITLE: Predictive Markers and Mechanisms of Persistent Psychotic-like Experiences in Children: An Adolescent Brain and Cognitive Development Study Analysis

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

PI_NAMEs: CHESTEK, CYNTHIA ANNE (contact)

PROJECT_TERMS: 3D Print;Academia;Adopted;Aerosols;biomarker identification;Brain;Cardiac;Catalogs;Clinical;Communication;Communities;Data;density;design;Devices;Electrodes;Electronics;Ensure;experimental study;Failure;Feedback;first-in-human;FPS-FES Oncogene;Funding;Goals;Human;Implant;implantable device;Industry;Investments;Lasers;Lead;Libraries;Location;Mechanics;Medical;Medical Device;microchip;Modification;Monkeys;nano;Nerve;neural prosthesis;novel;Ocular Prosthesis;open source;operation;Operative Surgical Procedures;Persons;Pilot Projects;power consumption;powered prosthesis;prevent;prosthetic hand;prototype;Publishing;Research;Research Personnel;Safety;safety testing;Sampling;seal;Specific qualifier value;Spinal;Spinal cord injury;supply chain;System;Technology;Test Result;Testing;Time;Titanium;usability;Utah;Validation;Vendor;verification and validation;Vision;Welding;wireless communication;Work

PROJECT_TITLE: Nest#1-High density Interconnect with Variable Electronics (HIVE)


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE  In this project, we will create a reference atlas containing microstructure growth curves of different brain regions across the lifespan, which enables us to assess neurobiological variability at the individual level. This will create an opportunity to advance clinical translation, where individual neurobiological signatures can be used to predict clinical outcomes. We will showcase the value of this approach by showing the clinical relevance of microstructure variations in early psychosis patients.

PI_NAMEs: KRAGULJAC, NINA VANESSA (contact);MARQUAND, ANDRE F.;ZHANG, HUI

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Age;Anatomy;Anisotropy;Antipsychotic Agents;Archives;Atlases;Autopsy;biological systems;Brain;Brain region;Calibration;Characteristics;Chronic;Clinical;clinical predictors;clinical subtypes;clinical translation;clinically relevant;Code;cohort;connectome data;Data;Data Pooling;data quality;Data Set;Decision Making;deep learning;deficit syndrome;density;design;Diffusion Magnetic Resonance Imaging;Disease;duration of untreated psychosis;early psychosis;Ecosystem;experience;Genetic;Goals;graphical user interface;gray matter;Growth;Heterogeneity;Human;Image;indexing;Individual;individual patient;individual variation;insight;interest;life span;Maps;Measures;Medical;Mental disorders;Modeling;Neurites;Neurobiology;neuroimaging;Noise;Normal Range;Online Systems;Onset of illness;Outcome;Output;Participant;patient population;Patients;Performance;Pharmaceutical Preparations;Phenotype;Physiological;Play;Population;precision medicine;predict clinical outcome;Prediction of Response to Therapy;Probability;Psychiatry;Publishing;Quality Control;Reference Values;Research Domain Criteria;response;Role;Sampling;Schizophrenia;secondary analysis;Severities;sex;Structural defect;Structure;Symptoms;Techniques;Testing;treatment response;Validation;Variant;virtual;Visualization;white matter;Work

PROJECT_TITLE: Mapping heterogeneity of brain microstructural abnormalities in psychiatric disorders with normative modelling


ADMINISTERING_IC: EB

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE An interdisciplinary approach is required to better prepare future clinician scientists for the challenges and opportunities of imaging research in Precision Medicine. The TOP-TIER T32 program trains post-doctoral clinician scientists in the performance of translational imaging research, providing them with the skill set to transition to independent investigators capable of taking imaging research from bench-to-bedside and imaging innovation into tomorrow’s healthcare.

PI_NAMEs: AN, HONGYU ;WAHL, RICHARD LEO;WOODARD, PAMELA K (contact)

PROGRAM_OFFICER_NAME: ERIM, ZEYNEP

PROJECT_TITLE: Training OPportunites in Translational Imaging Education and Research (TOP-TIER)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

PI_NAMEs: MAKOWSKI, NATHANIEL STEVEN (contact)

PROJECT_TERMS: analog;Ankle;Cerebral Palsy;Clinical;Communication;Communities;Computer software;Data;design;detection method;Development;digital;Distal;Documentation;Ecosystem;Electromagnetics;electronic sensor;Electronics;Equilibrium;Extravasation;Failure;Feasibility Studies;Feedback;foot;Future;Gait;Goals;Hand;Health;Heart;Heel;Human;human subject;Implant;implanted sensor;improved;improved mobility;interoperability;Limb structure;Location;Lung;Measurement;Measures;Monitor;Movement;open source;Organ;Output;Paralysed;Pathway interactions;Persons;Positioning Attribute;Process;Protocols documentation;Quality of life;Research;Research Support;sensor;Signal Transduction;Spinal cord injury;Stomach;Stroke;System;Testing;translation to humans;Walking

PROJECT_TITLE: Nest#2-Sensor Withdrawn from A Remote Module (SWARM)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The UAB Gregory Fleming James Cystic Fibrosis Research Center (CF Center), supported by the NIH P30, is dedicated to advancing high-impact, multidisciplinary research that heightens the field’s understanding of CF disease mechanisms and accelerates the development of treatments for availability to CF patients. Success toward this goal is made possible by the Center’s well-funded Research Base, robust and cutting-edge Biomedical Research Core resources and services, effective Administrative Core offerings, and successful Pilot & Feasibility and Enrichment Programs, in addition its strong commitment from the University and its role as a valuable local, national, and international clinical hub. Progress is measured by the output of innovative contributions, scientific discovery, and clinical translation designed to improve the lives of patients with the disease.

PI_NAMEs: DAVIS, BRIAN R. (contact)

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Acceleration;Achievement;Address;age related;Animal Model;Animals;Area;Bacterial Infections;base;Basic Science;Biological Assay;Biological Models;Biomedical Research;career development;Cell Line;Cell model;Cells;Cellular Assay;Chronic;Clinical;clinical center;Clinical Sciences;clinical translation;Clinical Trials;Collaborations;collaborative environment;Collection;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Dedications;design;Disease;drug discovery;Drug Industry;Education;Educational workshop;effectiveness research;Elements;Environment;Erythrocytes;Evaluation;Exhibits;experience;Faculty;Feasibility Studies;Ferrets;Fostering;Foundations;Functional disorder;Funding;Future;gene therapy;Generations;Genetic;Goals;Growth;Hemolysis;Human;Image;improved;in vivo;Infection;Inflammation;innovation;Institution;Interdisciplinary Communication;Interdisciplinary Study;International;invention;Investigation;Investigational Therapies;Ketones;Knowledge;Laboratories;Leadership;Lung;Lung Diseases;Measures;member;Mentorship;model development;multidisciplinary;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Nonsense Mutation;novel;novel therapeutics;Organoids;Outcome Measure;Output;Pathogenesis;Patients;Physiological;Pilot Projects;Population;Positioning Attribute;Pre-Clinical Model;Predisposition;prevent;programs;Rattus;Reagent;repository;Research;Research Personnel;Research Priority;Research Support;Resources;respiratory;response;Role;Sampling;Science;Scientific Advances and Accomplishments;Senior Scientist;Series;Services;Site;Structure;success;Supplementation;synergism;System;Techniques;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapy development;tool;tool development;Training;training opportunity;Translating;Translational Research;translational scientist;translational therapeutics;Translations;Treatment Protocols;United States;United States National Institutes of Health;Universities;VX-770;Work;working group

PROJECT_TITLE: UAB CF Research and Translation Core Center


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Disability Research;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation

PI_NAMEs: FU, MICHAEL JOHN (contact)

PROJECT_TITLE: Nest#3-Wearable Interoperable Neuroprosthesis Gear (WING)


PI_NAMEs: BEDWELL, DAVID M. (contact)

PROJECT_TERMS: Acceleration;Advisory Committees;Area;base;Biochemistry;Biomedical Research;Breast Fibrocystic Disease;Businesses;career development;Career Mobility;Cells;clinical center;Clinical Sciences;Collaborations;Communication;Communities;Core Facility;COVID-19;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Development;Diabetes Mellitus;Disease;drug development;Ensure;Environment;Equipment;equipment acquisition;Evaluation;Evolution;experience;Faculty;Fostering;Foundations;Funding;gene therapy;genetic technology;Goals;Grant;Growth;Human Resources;innovation;innovative technologies;Institution;Interdisciplinary Study;invention;Investments;Leadership;Medicine;meetings;member;Molecular Genetics;Monitor;mucus clearance;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Newsletter;next generation;novel;nutrition;Obesity;operation;pandemic disease;Participant;Pediatrics;Positioning Attribute;Procedures;Productivity;Program Development;programs;Rattus;Recommendation;Research;research and development;Research Personnel;Resources;Science;Scientist;Site;Site Visit;skills;success;symposium;synergism;System;Technology;Training;Translational Research;Translations;United States National Institutes of Health;Utilization Review;web site;Writing

PROJECT_TITLE: UAB CFRC Administrative Core


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: BERKELEY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Our understanding of primate evolution was transformed by the sequencing and assembly of the human  reference genome which identified the content and context of genes shared amongst the many different taxa in  the primate lineage. Here we propose to construct complete reference genomes from 50 diverse primate species  spanning 75 million years of evolution. This resource will greatly enhance the potential for research that will  advance our understanding of primate evolutionary history, population genomics, infectious disease, human  origins, and primate biodiversity and conservation.

PI_NAMEs: GARRISON, ERIK ;MITCHELL, MATTHEW WILLIAM;SUDMANT, PETER HESHEDAHL (contact)

PROGRAM_OFFICER_NAME: WETTERSTRAND, KRIS A

PROJECT_TERMS: Acceleration;base;Biocompatible Materials;Biodiversity;Biology;Cell Line;Collection;Communicable Diseases;Communities;Cytogenetics;Data;Deposition;DNA;Ecology;Ensure;Evolution;Generations;Genes;Genome;genome annotation;genome browser;genome resource;Genomics;Graph;Haplotypes;Human;Human Genome;human pangenome;human reference genome;improved;Information Resources;insight;Macaca;Medical Research;Methods;Monkeys;nanopore;nonhuman primate;open data;Pan Genus;pan-genome;Pongidae;Population;Primates;Recording of previous events;reference genome;Research;Research Personnel;Resources;scaffold;Sequence Alignment;Source;Technology;Validation;Variant;vertebrate genome;Work

PROJECT_TITLE: A compendium of complete primate reference genomes to facilitate conservation, genomics, and ecology


PI_NAMEs: VRABEC, TINA LOUISE (contact)

PROJECT_TERMS: Action Potentials;Area;Arrhythmia;Autonomic nervous system;bioelectronics;Bronchial Spasm;Charge;Chronic;chronic neuropathic pain;Chronic Obstructive Pulmonary Disease;clinical application;Communication;Communities;Complex;Data;Devices;Disease;Down-Regulation;Electric Stimulation;Electrodes;Ensure;Failure;Fiber;Frequencies;Future;Goals;Heart;Histologic;Implant;in vivo;Injections;Knowledge;Licensing;Maps;Measurement;Measures;Medical;multimodality;Muscle;Nerve;Nerve Block;Nervous System;Nervous System control;neural;Neural Conduction;neuroregulation;Nociception;open source;Output;Physiologic pulse;Physiological;prevent;Procedures;Protocols documentation;Publishing;Ramp;Regulation;Reproducibility;Research;Research Personnel;research study;Safety;spasticity;Speed;Sphincter;System;Techniques;Testing;Therapeutic;Therapeutic Effect;Time;tool;Translations;urinary;voltage;web site;Width;Work

PROJECT_TITLE: Nest#4-Nerve Excitation Control Through AC Regulation (NECTAR)


PI_NAMEs: SMITH, BRIAN  (contact)

PROJECT_TITLE: CORE: Technical Integration (STINGER) and Dissemination (Buzz) Core for COSMIIC HORNET


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Neurosciences;Rehabilitation

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Our movements are shaped by sensory information, and though much progress has been made in understanding how proprioceptors (muscle sensory neurons) shape motor function, much less is known about how touch receptors (skin sensory neurons) influence motor pathways. To generate a complete picture of how sensory information affects motor actions, this project incorporates a multidisciplinary approach to provide a functional roadmap of how skin touch receptors interact with spinal cord motor centers to shape movement. By understanding the final path for movement organization (i.e., the spinal cord) our research lays the critical foundation for novel ways to modulate spinal circuits for improving motor function affected by disease or injury.

PI_NAMEs: ABRAIRA, VICTORIA EUGENIA GUADALUPE (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Address;Affect;Afferent Neurons;Anatomy;Behavior;Behavioral Assay;behavioral study;Biological Assay;Biomedical Research;Complex;Computer Vision Systems;Coupled;Cutaneous;cutaneous sensory neurons;Data;Disease;electrical property;Electrophysiology (science);Environment;Extensor;Flexor;Foundations;Genetic;genetic approach;Hindlimb;improved;in vivo;Individual;Injury;insight;interdisciplinary approach;Interneurons;Investigation;Joints;Lateral;Length;Limb structure;Link;Locomotion;Machine Learning;Maps;Mechanics;Modality;Motor;Motor Activity;motor behavior;motor function improvement;Motor Neurons;Motor output;Motor Pathways;mouse genetics;Movement;multimodality;Muscle;Muscle Contraction;Nervous System Disorder;neural circuit;Neurons;Neurosciences;novel;novel strategies;novel therapeutics;Organ;Output;Parvalbumins;Pathway interactions;Pattern;Persons;Positioning Attribute;programs;Property;Proprioception;Proprioceptor;Quality of life;receptor;Reflex action;Research;Resolution;response;Sensorimotor functions;Sensory;sensory input;sensory stimulus;Shapes;Skin;Slice;somatosensory;Speed;Spinal;Spinal Cord;Spinal cord posterior horn;Structure;Synapses;Technology;Testing;tool;Touch sensation;vibration;Visualization;Walking;Work

PROJECT_TITLE: Touching on locomotion: an anatomical and functional analysis of spinal cord circuits that shape the way we move

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_NAME: BROAD INSTITUTE, INC.

PHR: NARRATIVE The overall goal of this project is to generate high quality sequence data to help build a data resource for the pediatric research community. This resource will help researchers understand the underlying mechanisms of disease, leading to more refined diagnostic capabilities and ultimately more targeted therapies or interventions.

PI_NAMEs: GABRIEL, STACEY  (contact)

PROGRAM_OFFICER_NAME: FOURNIER, MARCIA VASCONCELLOS

PROJECT_TERMS: Acceleration;aggregation database;All of Us Research Program;Back;Catalogs;causal variant;Child;Childhood;Clinical;cohort;Collaborations;Collection;Communication;Communities;computerized data processing;cost;Data;data analysis pipeline;data exploration;data harmonization;data integration;data management;data resource;data sharing;data standards;Defect;Detection;Diagnostic;diagnostic value;Disease;Elements;empowerment;Ensure;Evaluation;exome;Family;flexibility;gene discovery;Gene Frequency;Generations;Genes;Genetic;Genome;genome analysis;genome resource;genome sequencing;genomic data;Genomics;Goals;Human Genome;Intake;interest;Intervention;Intuition;large datasets;Large-Scale Sequencing;Libraries;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical Genetics;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;Output;Pathogenicity;Patients;Pediatric Research;Phase;Phenotype;Population Genetics;Preparation;Process;programs;Research;Research Personnel;Resources;RNA Splicing;Role;Sampling;Structural Congenital Anomalies;success;targeted treatment;The Cancer Genome Atlas;Therapeutic;Tissues;tool;Trans-Omics for Precision Medicine;transcriptome sequencing;United States National Institutes of Health;Variant;whole genome;Work

PROJECT_TITLE: GMKF competing renewal


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Clinical Research;Cystic Fibrosis;Lung;Rare Diseases

PI_NAMEs: SOLOMON, GEORGE MARTIN (contact)

PROJECT_TERMS: Adopted;airway epithelium;airway inflammation;airway surface liquid;anatomic imaging;Animal Model;Animals;Area;Award;Biological Assay;Biological Models;Biology;Biopsy;Body System;Bronchi;Cell Culture System;Cell Culture Techniques;Cell model;Cells;Clinical;Clinical Trials;Collaborations;Complex;Cost Savings;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Development;digital;drug discovery;Dyes;Epithelial Cells;Epithelium;Equipment;Evaluation;Excision;Fostering;Frequencies;Functional disorder;Functional Imaging;Funding;Gastrointestinal tract structure;gene therapy;Genetic;Health Insurance Portability and Accountability Act;Heterozygote;Human;Human Resources;human subject;human tissue;Hydration status;Image;improved;In Situ;In Vitro;in vivo;in vivo evaluation;Individual;innovation;insight;Institutional Review Boards;Investigation;Ion Transport;Ions;Laboratories;Laboratory Research;Lung;Lung Transplantation;material transfer agreement;Measurement;Measures;Messenger RNA;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;Mucociliary Clearance;Mucous body substance;Nose;novel;novel therapeutics;Operative Surgical Procedures;Optical Coherence Tomography;Organ;Organoids;Pathogenesis;Pathway interactions;Permeability;Phenotype;Procedures;Process;Productivity;Property;protein expression;Proteins;Publications;Pulmonary Cystic Fibrosis;quality assurance;Reagent;real-time images;Rectum;repair strategy;repaired;repository;Reproducibility;Research;Research Design;Research Personnel;Research Support;Resolution;Resources;response;Rights;Safety;sample fixation;Sampling;Science;Scientist;Sinus;Source;standard measure;Standardization;Surface;Swelling;System;Techniques;Technology;Testing;Thick;Tissues;Trachea;Training;Translating;Translations;United States National Institutes of Health;Validation;Viscosity;Western Blotting;Work

PROJECT_TITLE: UAB CFRC Core A: Cell Model and Evaluation Core


ADMINISTERING_IC: AR

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Injury - Accidents and Adverse Effects

ORG_CITY: Charlottesville

ORG_NAME: SPRINGBOK, INC.

ORG_STATE: VA

PHR: PROJECT NARRATIVE Rotator cuff tears are highly problematic for large patient populations such that clinicians need innovative tools to better determine who could benefit from surgical repair. This project will result in revolutionary technology capable of fast, precise measures of muscle atrophy and fat infiltration for accurate pre-intervention evaluation.

PI_NAMEs: BLEMKER, SILVIA SALINAS;RIEM, LARA ISABELLA (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: 3-Dimensional;Adipose tissue;Algorithms;artificial intelligence algorithm;Artificial Intelligence platform;Atrophic;automated algorithm;automated segmentation;Clinical;clinical practice;Clinical Research;Clinical Treatment;cloud based;convolutional neural network;cost;cost outcomes;Data;Data Display;Databases;Decision Making;deep learning;demographics;Development;Diagnosis;digital;Digital Imaging and Communications in Medicine;Evaluation;experience;Fatty acid glycerol esters;functional restoration;Goals;healing;health assessment;Healthcare;Human;Image;improved;improved outcome;Infiltration;innovation;Institution;Intervention;Lead;Legal patent;machine learning algorithm;Magnetic Resonance Imaging;Manuals;Manuscripts;Marketing;Measurement;Measures;Methods;MRI Scans;Muscle;Muscular Atrophy;Natural regeneration;novel;novel strategies;Operative Surgical Procedures;Orthopedic Procedures;Orthopedic Surgery;Orthopedics;Outcome;outcome prediction;Pathologic;Pathology;Patient Care;patient population;Patients;Phase;Postoperative Period;postoperative recovery;procedure cost;Process;prospective;prototype;quality assurance;reconstruction;Reconstructive Surgical Procedures;recruit;repaired;research clinical testing;Rotator Cuff;rotator cuff tear;Scanning;Secure;Shoulder;Slice;success;supraspinatus muscle;Surgeon;surgery outcome;System;Technology;Tendon structure;Testing;tool;Training;Universities;Unnecessary Procedures;Unnecessary Surgery;Virginia;Visual;web site;Wisconsin;Work

PROJECT_TITLE: Clinical evaluation of a commercially viable machine learning algorithm to automatically detect shoulder muscle pathology


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cystic Fibrosis;Genetics;Lung;Rare Diseases

PI_NAMEs: BIRKET, SUSAN ELIZABETH (contact)

PROJECT_TERMS: Acceleration;Animal Model;Animals;Area;Biological Assay;Biomedical Research;Breeding;Bronchoscopy;Cellular biology;Characteristics;Chronic;Cilia;clinical predictors;clinical translation;clinically relevant;Collaborations;Communities;Complement;Cost Savings;Coughing;CRISPR/Cas technology;Crossbreeding;Cystic Fibrosis;cystic fibrosis mouse;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Defect;Disease;Drug Delivery Systems;Drug Monitoring;effectiveness evaluation;Electrophysiology (science);End Point Assay;Endocrine system;epithelial Na+ channel;Epithelial Physiology;Epithelium;Equipment;Family suidae;Ferrets;Fostering;Functional disorder;Gastrointestinal tract structure;Gene Targeting;gene-editing approach;Generations;Genes;Genetic;Genetic Heterogeneity;genetic manipulation;Genome;Genotype;Glucose Intolerance;Goals;human disease;Image;imaging modality;in vivo;innovation;interest;International;Knock-out;Laboratories;Lung;Measurement;Measures;Mediating;microCT;Modeling;Monitor;mouse model;Mouse Strains;mRNA Decay;Mucociliary Clearance;mucus clearance;Mus;Mutation;Nose;novel;novel therapeutics;Obstruction;Optical Coherence Tomography;Outcome Measure;Pancreas;Pathogenesis;Pathway interactions;Pharmacologic Substance;Phenotype;Physiological;Play;Plethysmography;porcine model;pre-clinical;Pre-Clinical Model;Predisposition;promoter;Property;Pseudomonas aeruginosa infection;Publications;pulmonary function;Rattus;Recombinants;reproductive tract;Research;Research Personnel;Research Priority;Research Support;Resource Sharing;Resources;Respiratory System;Role;Sample Size;Specimen Handling;Statistical Data Interpretation;Technical Expertise;Techniques;Technology;Tissue Sample;Tissues;tool;transcription activator-like effector nucleases;Transgenic Organisms;Translations;treatment response;ultra high resolution;ultrasound;X-Ray Computed Tomography

PROJECT_TITLE: UAB CFRC Core B: Animal and Preclinical Models Core


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Gene Therapy;Genetics;Human Genome;Immunotherapy;Precision Medicine;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative For the significant fraction of metastatic breast cancer patients that are yet unable to realize the unparalleled benefits of cancer immunotherapy, focused ultrasound (FUS) is poised to play a transformative role - owing to its diverse capacity for destroying solid tumor tissue, enhancing drug delivery and promoting anti-tumor immune response. The goal of this proposal is to design and deploy rational combinations of FUS and immunotherapy in primary and disseminated breast cancers (with special emphasis on CAR T cell therapy), as well as to develop non-invasive tools for monitoring and individualizing these combinations through the use of innovative approaches in molecular imaging, liquid biopsy and radiogenomics. The highly translational structure of this proposal offers the potential for quantum improvements in metastatic breast cancer prognosis and therapy and meanwhile ushers FUS into the burgeoning era of precision immuno-oncology.

PI_NAMEs: SHEYBANI, NATASHA DIBA (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Abbreviations;Acceleration;Acoustics;adaptive immune response;adaptive immunity;Adjuvant;Administrator;advanced breast cancer;Ally;anti-PD-1;anti-tumor immune response;Appointment;Authorship;biomarker discovery;Biomedical Engineering;biomedical imaging;Biopsy Specimen;Blood Screening;breast cancer metastasis;Breast Cancer Patient;Breast Cancer therapy;cancer biomarkers;Cancer Etiology;cancer genomics;cancer immunotherapy;Cancer Prognosis;cancer therapy;cancer type;CAR T cell therapy;career;CD8-Positive T-Lymphocytes;Cessation of life;chemotherapy;chimeric antigen receptor T cells;circulating biomarkers;Clinical;Clinical Protocols;Clinical Trials;Collaborations;Combination immunotherapy;combinatorial;Companions;Data;Deposition;design;Disease;Drug Delivery Systems;Engineering;exosome;Extramural Activities;Fellowship;first-in-human;Focused Ultrasound;forging;Fortification;Foundations;Funding;gemcitabine;genomic data;genomic signature;Genomics;Goals;graduate student;Home;HRK gene;Human Resources;Image;imaging informatics;Imaging Techniques;Immune;immunoengineering;immunogenicity;Immunologics;Immunology;Immunooncology;ImmunoPET;Immunotherapy;improved;Infrastructure;innovation;Institution;Institutional Review Boards;International;Intervention;Knowledge;Lesion;liquid biopsy;machine learning framework;Malignant Breast Neoplasm;Maps;Mechanics;Mediating;member;Mentors;Mentorship;Metastatic breast cancer;Metastatic malignant neoplasm to brain;Molecular;molecular imaging;Monitor;Multimodal Imaging;Mus;Myelogenous;next generation;novel;novel marker;Outcome;Patients;PD-1 blockade;Peer Review;Peripheral;personalized immunotherapy;personalized medicine;PET/CT scan;Play;Positioning Attribute;Postdoctoral Fellow;pre-clinical;Precision cancer therapy;precision oncology;preclinical study;predict clinical outcome;predicting response;prognostic;programs;Publications;quantum;Radiogenomics;radiological imaging;Radiology Specialty;radiomics;Recurrence;Regimen;Research;research faculty;Research Training;Resources;response;response biomarker;risk stratification;Role;senior faculty;skills;Solid Neoplasm;Structure;synergism;T cell infiltration;T-Lymphocyte;targeted treatment;Techniques;Technology;tenure track;Testing;theranostics;Therapeutic;Time;tool;Training;Translating;translational pipeline;Translational Research;Treatment Efficacy;trial design;tumor;tumor DNA;Tumor Immunity;Tumor Markers;Tumor Tissue;ultrasound;United States;United States National Institutes of Health;Universities;University of Virginia Cancer Center;Virginia;Women's mortality

PROJECT_TITLE: Immunoengineering Next-Generation Cancer Therapies with Focused Ultrasound

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: Cholesterol crystals (CC), which are formed by increased lipid levels, cause tissue damage and are recognized by the immune system as foreign bodies because of their shape, firmness and inability to be dissolved. In this study, we will test whether retinal CC can cause retina damage leading to the development of diabetic retinopathy.

PI_NAMEs: BUSIK, JULIA V;GRANT, MARIA BARTOLOMEO (contact);PIKULEVA, IRINA A

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Affect;Arterial Fatty Streak;Blood;Blood Vessels;Blood-Retinal Barrier;Bone Marrow;CCL2 gene;cell injury;Cells;cellular development;Cholesterol;Cholesterol Homeostasis;Choroid;Chronic;Circulation;Complement;Complement Activation;complement pathway;Coupled;Crystal Formation;Cyclodextrins;Cytochrome P450;cytokine;Dehydration;Development;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Disease;Dyslipidemias;Endothelium;Ethanol;Excision;extracellular;Extracellular Space;Foreign Bodies;Funding;Genes;human subject;Immune system;Immunohistochemistry;in vivo;Infiltration;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Innate Immune System;Intercellular adhesion molecule 1;Interleukin-1 beta;Lectin;lipid metabolism;Lipids;Location;Macrophage;Masks;Mediating;Microglia;monocyte;Mus;Neural Retina;novel;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;pharmacologic;Photoreceptors;Physiological;prevent;Production;Prognostic Marker;Publishing;repaired;Repression;Retina;retinal damage;Scanning Electron Microscopy;Shapes;SIRT1 gene;Source;Structure;Structure of retinal pigment epithelium;Testing;tissue preparation;tissue processing;Tissues;X ray spectroscopy

PROJECT_TITLE: Cholesterol homeostasis in pathogenesis of DR


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHICAGO

ORG_DEPT: MISCELLANEOUS

ORG_NAME: NORTHEASTERN ILLINOIS UNIVERSITY

ORG_STATE: IL

PHR: OVERALL – PROJECT NARRATIVE The presence of major cancer health inequities in Chicago is well-documented. The Chicago Cancer Health Equity Collaborative (ChicagoCHEC), a comprehensive cancer research partnership between the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, the University of Illinois at Chicago, and Northeastern Illinois University, builds upon its productive first U54 award to continue strengthening collaborative infrastructure and implementing innovative cancer research, education, and outreach programs aimed at eliminating Chicago’s deeply-engrained cancer disparities.

PI_NAMEs: CIECIERSKI, CHRISTINA  (contact);FEINGLASS, JOSEPH M;FILUS, LIDIA ;FITZGIBBON, MARIAN L.;JIMBO, MASAHITO ;SIMON, MELISSA A.

PROGRAM_OFFICER_NAME: SAN MIGUEL-MAJORS, SANDRA L

PROJECT_TERMS: Acceleration;Advanced Malignant Neoplasm;African American;anti-cancer research;Applications Grants;Award;cancer health disparity;Cancer health equity;Cancer Research Infrastructure;Cancer Research Project;career;Chicago;Circadian Rhythms;Cities;Clinical;Collaborations;Communities;community engagement;Community Outreach;community partners;Comprehensive Cancer Center;Decision Making;Dedications;disability;DNA Double Strand Break;Double Strand Break Repair;early-career faculty;Education;Education and Outreach;education research;empowerment;Evaluation;experience;Extramural Activities;Faculty;forging;Fortification;Funding;Funding Mechanisms;Generations;Goals;Grant;gut microbiome;Health Disparities Research;health disparity populations;health inequalities;Hematopoietic Stem Cell Transplantation;high risk;Hispanic-serving Institution;Illinois;improved;Infrastructure;innovation;Institution;Lead;Leadership;Long-Term Effects;lung cancer screening;Malignant Neoplasms;men;Mentors;mHealth self-management;Midwestern United States;Minority;minority student;Mission;next generation;oral microbiome;outreach;outreach program;Peer Review;Pilot Projects;Positioning Attribute;Prevention;Productivity;programs;Publications;rapid growth;Records;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Science;Scientist;social;Students;Survivors;survivorship;tool;Training;Translational Research;Transplant Recipients;Underrepresented Populations;Underrepresented Students;underserved community;Underserved Population;Universities;Variant

PROJECT_TITLE: 2/3: The Chicago Cancer Health Equity Collaborative (ChicagoCHEC)


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Cystic Fibrosis;Lung;Orphan Drug;Rare Diseases

PI_NAMEs: ROWE, STEVEN MARK (contact)

PROJECT_TERMS: Acceleration;Address;Adult;airway epithelium;airway surface liquid;Alleles;Animal Model;Animals;base;Basic Science;biobank;Biological Assay;Biomedical Research;Calorimetry;Cell model;Cell Physiology;Cellular Assay;Child;Chlorides;Clinical;clinical center;clinical outcome measures;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials;Collaborations;collaborative environment;Continuous Glucose Monitor;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;data management;Defect;Delta F508 mutation;design;Development;Diagnostic;Disease;Dual-Energy X-Ray Absorptiometry;Endocrine;Endocrine system;Endocrinology;Environment;Epithelial Cells;Epithelium;Erythrocytes;Evaluation;experience;Faculty;Feasibility Studies;Fostering;Frequencies;Functional disorder;Functional Imaging;Funding;Future;gastrointestinal system;Gastrointestinal tract structure;gene therapy;Genetic;Goals;Hemolysis;Host Defense;Human;human subject;human tissue;Image;improved;In Vitro;in vivo;Individual;Infection;Inflammation;innovation;insight;Institution;International;Intestines;Investigational Therapies;Ion Transport;Ketones;Laboratories;Link;Lung;Lung Diseases;Measurement;Measures;Metabolism;Methods;Monitor;Mucociliary Clearance;Mucous body substance;Mucous Membrane;Mutation;new therapeutic target;next generation;Nose;novel;novel therapeutic intervention;novel therapeutics;nutrition;Nutritional;Nutritional Study;Observational Study;Optical Coherence Tomography;Organoids;Outcome;Outcome Measure;Pathogenesis;Pathway interactions;Performance;physical property;Pilot Projects;Positioning Attribute;Process;programs;Pulmonary Cystic Fibrosis;quality assurance;Reagent;real-time images;Rectum;Research;Research Personnel;Research Project Grants;Resolution;Resources;response;Role;sample collection;Science;Scientific Advances and Accomplishments;Scientist;Secure;Senior Scientist;Sinus;Site;Specimen;Standardization;Structure;Supplementation;Surface;System;Techniques;Testing;Tissues;tool;Training;Translating;Translational Research;translational therapeutics;Translations;trial design;United States National Institutes of Health;Viscosity

PROJECT_TITLE: UAB CFRC Core C: Clinical and Translational Core


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: DE KALB

ORG_NAME: NORTHERN ILLINOIS UNIVERSITY

PHR: Project Narrative This project examines how school-age blind children acquire word meanings, and whether the trajectory of vocabulary development in blind children is altered or delayed relative to that in typically sighted children. Findings from this research have the potential to improve instructional approaches and language and literacy interventions for blind children.

PI_NAMEs: HARRIS, LINDSAY NICOLE (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Adult;Affect;Age;American;Area;blind;Blindness;Characteristics;Child;Child Language;Coenzyme A;cognitive development;Data Collection;Data Set;design;Developed Countries;Development;Developmental Disabilities;early childhood;Education;Environment;experience;Future;Gender;Goals;Illinois;improved;Incidence;Individual;innovation;Instruction;Intervention;Knowledge;Language;language comprehension;Language Development;language processing;Learning;Learning Disabilities;Linguistics;literacy;middle childhood;Minor;open data;Outcome;Participant;Patient Recruitments;Patient Self-Report;Pattern;Persons;Phase;Population;Positioning Attribute;Psycholinguistics;Publishing;Reading;reading ability;Reading Disabilities;recruit;Research;Research Personnel;Retinopathy of Prematurity;School-Age Population;sensory input;seventh grade;social inclusion;Socioeconomic Status;Speech;Surveys;symposium;Testing;timeline;tool;Underserved Population;Unemployment;university student;verbal;Very Low Birth Weight Infant;virtual;Vision;Visual;Visual impairment;Visually Impaired Persons;Visually Impaired Students;Vocabulary;word learning;Writing

PROJECT_TITLE: Word Learning and Vocabulary Development in Blind Children


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: CIECIERSKI, CHRISTINA  (contact)

PROJECT_TITLE: Administrative Core


PI_NAMEs: HIBDON, JOSEPH EDWARD (contact)

PROJECT_TERMS: Achievement;Advisory Committees;analytical tool;anti-cancer research;Award;Benchmarking;cancer health disparity;Cancer health equity;Cancer Research Project;career;career development;catalyst;Chicago;Clinical Sciences;Communication;community engaged approach;Consultations;Counseling;Data;Data Analyses;data tools;Decision Making;Development;early-career faculty;Educational workshop;Ensure;Evaluation;experience;Faculty;faculty mentor;Foundations;Funding;Funding Mechanisms;Goals;Grant;Health;health disparity;improved;Incubators;Infrastructure;innovation;Institution;Intervention Studies;Knowledge;Leadership;Logic;mathematical model;member;Mentors;Mentorship;Mission;Modeling;Monitor;novel;Outcome;Performance;Pilot Projects;Process;process improvement;Program Development;programs;Progress Reports;Quasi-experiment;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Resources;Running;skills;Statistical Data Interpretation;Structure;Surveys;Time;Translational Research;Universities;Work

PROJECT_TITLE: Planning and Evaluation Core


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Healthcare organizations can improve patient safety by using their electronic health record data to identify what systems and process changes can prevent harm to patients. We will implement methods to help organizations electronically identify patients who may have experienced errors and delays in diagnosis and understand why they occurred. Our center will create new knowledge, tools, and strategies that health care organizations can use for learning how to prevent and reduce harm from diagnostic error.

PI_NAMEs: SINGH, HARDEEP  (contact)

PROGRAM_OFFICER_NAME: HAUGSTETTER, MONIKA

PROJECT_TITLE: Diagnostic Safety Center for Advancing E-triggers and Rapid Feedback Implementation (DISCOVERI)


NIH_SPENDING_CATS: Cancer;Pediatric;Social Determinants of Health

PI_NAMEs: KAHOUADJI, NABIL  (contact)

PROJECT_TERMS: Address;African American;anti-cancer research;Area;Attention;cancer health disparity;Cancer health equity;Cancer Science;career;career development;career preparation;Chicago;Cities;college;Communities;community college;community engagement;community partners;Comprehensive Cancer Center;curriculum development;design;Development;disability;Disparity;Diverse Workforce;diversity and equity;Dryness;Education;education research;Educational Activities;Educational Curriculum;Educational Status;Ensure;Ethnic Origin;Evaluation;experience;Faculty;Fortification;Fostering;Foundations;Funding;Gender;Goals;Grant;Health Disparities Research;health disparity;Healthcare;high school;Hispanic;Illinois;Immersion;improved;Influentials;Institution;interest;Internships;laboratory experience;Laboratory Research;life-long learning;Link;lower income families;Malignant Neoplasms;Medical Students;Medicine;member;Mentors;Minority;minority student;Not Hispanic or Latino;peer;Postdoctoral Fellow;Program Evaluation;programs;Race;Readiness;Recording of previous events;Research;research faculty;Research Personnel;Research Project Grants;Science;science education;Science, Technology, Engineering and Mathematics Education;skills;social culture;Social Network;Structure;Student recruitment;Students;success;summer program;summer research;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;university student;Work

PROJECT_TITLE: Research Education Core


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Cancer

ORG_DEPT: VETERINARY SCIENCES

PHR: Project Narrative The UC Davis Comparative Oncology T32 program will provide an outstanding environment for biomedical research training. The goal is to train 1) veterinarian- and physician-scientists and 2) graduate students pursuing dual DVM-PhD degrees to integrate the study of companion animals, which have naturally occurring cancers, with human cancer biology and therapy (comparative oncology). This will create a new generation of scientists engaged in basic and translational cancer research that advances the health of people and animals.

PI_NAMEs: CANTER, ROBERT J.;CHEN, XINBIN  (contact);KENT, MICHAEL SEAN

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: comparative;Oncology;Training Programs

PROJECT_TITLE: UC Davis Comparative Oncology Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: LUEDKE, TRACY J (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;Advanced Malignant Neoplasm;anti-cancer research;Area;Award;Awareness;cancer care;cancer education;cancer health disparity;Cancer health equity;cancer prevention;Cancer Survivor;Cancer Survivorship;cancer therapy;Chicago;Cities;citizen science;Clinical;Clinical Trials;Collaborations;Communities;community engaged approach;community engagement;Community Health;Community Networks;community organizations;Community Outreach;community partners;community partnership;community-centered;Comprehensive Cancer Center;Continuity of Patient Care;Death Rate;Development;disability;Disabled Persons;Disparity;Dissemination and Implementation;Early Diagnosis;Education;Education and Outreach;education research;Educational Activities;ethnic minority;Evaluation;Event;evidence base;Evidence based practice;experience;Faculty;forging;Fostering;Funding;gender minority community;Geographic Locations;Grant;Health;health disparity populations;Health Educators;health equity;Health equity research;Health Fairs;Human;Illinois;Immersion;improved;Incidence;Individual;Inequity;innovation;Institution;Interview;Lead;Leadership;Linguistics;literacy;Localized Malignant Neoplasm;Low income;Malignant Neoplasms;Maps;member;men of color;minority communities;mortality;Needs Assessment;Neighborhoods;neoplasm registry;outreach;Outreach Research;peer;peer coaching;Penetrance;Persons;Phase;Population;Positioning Attribute;Prevention;process evaluation;Productivity;programs;racial minority;Recommendation;Research;Research Personnel;Research Project Grants;Resources;response;screening;Secure;Services;Sexual and Gender Minorities;Students;Surveys;survivorship;symposium;tool;underserved community;Underserved Population;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Cystic Fibrosis;Lung;Rare Diseases

PI_NAMEs: GAGGAR, AMIT  (contact)

PROJECT_TERMS: Address;Advisory Committees;Area;Award;base;Basic Science;career;career development;Career Mobility;Cells;Center Core Grants;clinical center;Clinical Sciences;Collaborations;Cystic Fibrosis;early-career faculty;Extramural Activities;Faculty;Feasibility Studies;Foundations;Funding;Funding Agency;Future;Goals;Grant;innovation;Institution;Interdisciplinary Study;Investments;Manuscripts;member;Mentors;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Outcome;Paper;Peer Review;Pilot Projects;process improvement;programs;Publications;Recommendation;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;Running;Surveys;Teacher Professional Development;Testing;Training;translational medicine;Translational Research;Translations;United States National Institutes of Health;Work

PROJECT_TITLE: UAB CFRC Pilot and Feasibility Program


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Mental Illness;Neurosciences;Psychosis;Serious Mental Illness

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative Experiencing, producing, and performing music can help the symptoms of psychotic illness but we do not know why. The predictive processing framework for brain and mind function and dysfunction helps us understand why people with psychosis perceive and believe unusual things about themselves, other people, and the world. Using tasks devised through the framework and a group musical intervention we aim to learn how and for whom music might be helpful so that, in future, we can deliver music more effectively to the people who will benefit.

PI_NAMEs: CORLETT, PHILIP  (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Analysis of Variance;Auditory Hallucination;Behavior;Behavioral;Belief;Biological Assay;Brain;Cells;Chemosensitization;Clinical Trials;Code;Complex;Computational Linguistics;Computer Models;Cues;design;Distress;Event;Expectancy;expectation;experience;Family member;follow-up;Friends;Functional disorder;Future;Hallucinations;Hearing;Impairment;improved;Individual;Intervention;Interview;Laboratories;Language;Learning;lexical;Light;Linguistics;Measures;Meta-Analysis;Mind;Modeling;Music;Music Therapy;musician;Neurons;Ownership;Participant;peer;Perception;Performance;Periodicity;Personal Satisfaction;Persons;Pharmacotherapy;Phase;power analysis;Procedures;Property;Psychiatrist;Psychiatry;Psychoses;Psychotherapy;Psychotic Disorders;psychotic symptoms;Publishing;Qualitative Research;Quality of life;Recording of previous events;Recovery;Research;Research Personnel;Rewards;Scheme;Self Concept;Series;severe mental illness;social;social engagement;social learning;Stimulus;Symptoms;Synaptic plasticity;Task Performances;Testing;theories;Toes;Uncertainty;Update;Voice;Work

PROJECT_TITLE: Songmaking in a Group (SING): Music, Hallucinations & Predictive Coding


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Clinical Research;Data Science;Dissemination and Implementation Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Primary Health Care;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE Pediatric asthma is a heterogeneous disease, with different etiologies, triggers, clinical manifestations, severities, and treatment responses. Identifying groups of children with asthma by those specific characteristics (i.e., asthma subtypes) can improve asthma management, including primary care and emergency treatment. This project applies novel privacy-preserving machine learning tools to a large (~ 20 million patients) real-world data source to identify pediatric asthma subtypes and their progression over time (i.e., progression subtypes), with the goal of improving care and outcomes for the millions of children with asthma in the United States.

PI_NAMEs: FISHE, JENNIFER NOEL (contact);XU, JIE

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Acute;Address;Adopted;Advisory Committees;Affect;Algorithms;Allergic;Asthma;asthma exacerbation;asthmatic patient;Caregivers;Caring;Cessation of life;Characteristics;Child;Childhood Asthma;Chronic Disease;Classification;Clinical;Clinical Data;clinical implementation;clinical practice;Clinical Research;Code;comorbidity;computable phenotypes;Data;Data Analyses;Data Analytics;Data Sources;deep learning;Digital biomarker;Direct Costs;Disease;Disease Progression;Dissemination and Implementation;diverse data;electronic health data;Electronic Health Record;electronic structure;Emergency Care;Emergency department visit;Emergency treatment;epidemiology study;Ethnic Origin;Etiology;Evolution;experience;Facilities and Administrative Costs;federated learning;Focus Groups;Goals;Health Care Costs;Healthcare Systems;Heterogeneity;Hospitalization;implementation efforts;improved;improved outcome;Individual;Information Technology;Institution;interest;Intubation;Investigation;Link;Machine Learning;machine learning framework;machine learning method;Methods;minority children;Modeling;multidimensional data;National Heart, Lung, and Blood Institute;Natural Language Processing;novel;Outcome;Outcomes Research;Outpatients;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Performance;pharmacologic;Phenotype;Population;Population Heterogeneity;Primary Care;privacy preservation;Proliferating;prototype;Public Health;public health relevance;Qualitative Research;Race;repository;Research;Risk;Sample Size;Schools;Severities;Site;social health determinants;socioeconomics;spatiotemporal;Specialist;Structure;structured data;Symptoms;Techniques;Testing;Time;tool;Translating;treatment response;United States;user centered design;Work

PROJECT_TITLE: Identifying pediatric asthma subtypes using novel privacy-preserving federated machine learning methods

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(02)M]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: The proposed research is relevant to public health because unmet social needs negatively influence health, increase utilization, perpetuate disparities, and increase health care costs. The proposed research is relevant to AHRQ's mission to safer, higher quality, and more affordable care by supporting efficient and effective delivery of services.

PI_NAMEs: VEST, JOSHUA RYAN (contact)

PROGRAM_OFFICER_NAME: SWIGER, JAMES

PROJECT_TITLE: Computable social factor phenotyping using EHR and HIE data

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative The complexity and breadth of its host-cell remodeling machinery make the malaria-causing parasite P. falciparum a rich and exciting system for the study of host-pathogen interactions. However, many of the molecular mechanisms underlying this parasite's ability to hijack human red blood cells remain enigmatic, as much of the P. falciparum proteome has proven recalcitrant to structural and biochemical characterization using traditional recombinant approaches. The proposed research will build upon our previous studies in structural microbiology of the malaria parasite and leverage recent advances in cryoelectron microscopy to directly visualize how protein complexes mediate host-pathogen interactions in malaria parasite-infected red blood cells, providing insight into malaria pathogenesis and informing structure-guided design of novel anti-malarial therapeutics.

PI_NAMEs: HO, CHI-MIN  (contact)

PROJECT_TERMS: Academia;Affect;Anti-malarials;Award;Biochemical;Biochemistry;Biological Assay;biological systems;Biophysics;Blood;Bypass;Cell membrane;Cells;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;collaborative environment;Communities;Contracts;Cryo-electron tomography;Cryoelectron Microscopy;Cytosol;Dedications;design;Development;Disease;Doctor of Philosophy;Drug Design;drug discovery;Drug resistance;Drug Targeting;Electron Microscopy Facility;empowerment;Epitopes;Equipment;Erythrocytes;experience;Faculty;Fostering;Funding;Future;Gatekeeping;Goals;Host Defense;Human;Immune system;Immunology;In Situ;In Vitro;Industry;Infrastructure;inhibitor;insight;Institution;Interdisciplinary Study;Invaded;Ions;Life Cycle Stages;Malaria;Mediating;Medicine;member;Membrane;Membrane Proteins;Mentors;Metabolic;Methods;Microbiology;Modification;Molecular;multidisciplinary;new therapeutic target;novel;novel therapeutics;Nutrient;Parasite resistance;Parasites;Parasitic Diseases;particle;pathogen;Pathogenesis;Pathway interactions;Persons;Plasma Cells;Plasmodium;Plasmodium falciparum;Population;Positioning Attribute;Postdoctoral Fellow;Process;professor;programs;Protein Biochemistry;protein complex;Protein Engineering;Protein Export Pathway;Protein Subunits;Protein translocation;Proteins;Proteome;Qualifying;Recombinants;Regulation;Research;Resolution;Risk;Role;Scientist;screening;Source;square foot;Structure;System;Techniques;tenure track;Therapeutic;Training;Universities;Vacuole;Vision;Visualization;wasting;Work;World Health Organization

PROJECT_TITLE: Molecular basis of effector protein export in the malaria parasite Plasmodium falciparum


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

PHR: Project Narrative:  PRSS1 mutations cause human hereditary pancreatitis with high risk of developing to pancreatic cancer. We developed a novel mouse model by expressing a mutant human PRSS1 to study the mechanisms of pancreatic cancer tumorigenesis. We expect these studies will significantly improve our understanding of this disease and provide new insights on interventions.

PI_NAMEs: JI, BAOAN  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Acinar Cell;acute pancreatitis;Age;Animal Model;autosome;Biochemical;Biological;Cancer Etiology;Cellular Stress;Cessation of life;Chronic;chronic pancreatitis;chymotrypsin C;cigarette smoking;Development;Disease;EIF-2alpha;endoplasmic reticulum stress;Environmental Risk Factor;Etiology;Event;extracellular;Functional disorder;Gene Mutation;Genes;genetic approach;Goals;hereditary pancreatitis;High Fat Diet;high risk;Human;human disease;human tissue;improved;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory milieu;insight;Intervention;Investments;Lesion;Life;Link;Malignant neoplasm of pancreas;Mediating;Modeling;mouse model;Mus;mutant;Mutation;Nature;novel;Obesity;Oncogenic;Pancreas;pancreas development;Pancreatic Adenocarcinoma;Pancreatic Ductal Adenocarcinoma;Pancreatic Intraepithelial Neoplasia;pancreatic tumorigenesis;Pancreatitis;PAR-2 Receptor;Pathogenesis;Pathway interactions;Patients;Penetrance;pharmacologic;Phenotype;Play;premalignant;prevent;Preventive;preventive intervention;Property;protein expression;Proteinase-Activated Receptors;Recurrence;Regulation;Risk;Risk Factors;Role;Signal Pathway;Signal Transduction;Smoking;SRC gene;Testing;Therapeutic Intervention;tool;TP53 gene;transcription factor;transcription factor CHOP;transgene expression;Trypsin;Trypsinogen;tumorigenesis

PROJECT_TITLE: PRSS1 Mutation and Pancreatic Cancer Tumorigenesis

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: LUBBOCK

ORG_NAME: TEXAS TECH UNIVERSITY

PHR: The proposed research will use molecular simulations to reveal new rational design principles of light-regulated drugs with minimized side effects in chemotherapy. Also, it will elucidate the electron transfer mechanism in proteins associated with circadian rhythm, magnet field sensing, and energy metabolism. The microscopic understanding of these biochemical reactions from a quantum perspective will be foundational for biomedical research in the future.

PI_NAMEs: LIANG, RUIBIN  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Biochemical Reaction;Biology;Biomedical Research;chemical kinetics;chemical reaction;Chemicals;chemotherapy;circadian pacemaker;Circadian Rhythms;Complex;computerized tools;Computing Methodologies;cost;cryptochrome;design;Electron Transport;Electronics;Electrons;Energy Metabolism;Environment;Enzymes;Event;Future;human subject;insight;interest;Laboratories;Light;magnetic field;Metabotropic Glutamate Receptors;Methodology;Methods;Microscopic;Molecular;molecular mechanics;Motion;Nature;next generation;Nuclear;optogenetics;Organism;Pathway interactions;Pharmaceutical Preparations;Process;programs;Protein Conformation;protein structure;Proteins;PUVA Photochemotherapy;quantum;Quantum Mechanics;rational design;Reaction;Research;response;Risk;Role;Sampling;Science;side effect;Signal Transduction;simulation;System;Techniques;TRP channel

PROJECT_TITLE: Understanding electronically non-adiabatic reactions in biomolecules with multiscale simulations


NIH_SPENDING_CATS: Atherosclerosis;Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Inflammatory Bowel Disease;Machine Learning and Artificial Intelligence;Patient Safety;Pediatric;Precision Medicine;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Polygenic risk scores (PRS) use genetic data to predict the likelihood or (risk score) that a person will develop a specific disease/trait. We will to recruit 2,500 patient from across the CHOP network, about 75% of whom will be of African ancestry, and calculate and return PRSs for 20 diseases/traits to all. Target diseases include asthma, autoimmune disease, inflammatory bowel disease, lipid levels, and diabetes, and we will provide patients and provide with extensive education and clinical supports.

PI_NAMEs: HAKONARSON, HAKON  (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Address;Adult;African American population;African ancestry;Age of Onset;Area;Asthma;Autoimmune Diseases;biobank;Boston;cardiovascular disorder risk;care outcomes;Caring;chatbot;Child;Childhood;Clinical;clinical decision support;clinical efficacy;clinical implementation;cluster randomized design;Collaborations;collaborative approach;Communication;Communities;Coronary Arteriosclerosis;Crohn's disease;Data;Data Set;Development;Diabetes Mellitus;Disease;disparity reduction;Education;Educational Materials;Electronic Health Record;Electronic Medical Records and Genomics Network;ethical, legal, and social implication;ethnic minority;experience;Focus Groups;Genetic;Genetic Risk;genome-wide;Genomics;Genotype;Goals;Health;health assessment;health care delivery;health disparity;health disparity populations;Health Personnel;Health Professional;Healthcare;Hyperlipidemia;improved;improved outcome;Inequity;Inflammatory Bowel Diseases;Infrastructure;innovation;Institutional Review Boards;Insulin-Dependent Diabetes Mellitus;Link;Lipids;Measures;Methodology;Minority;Minority Groups;Minority Recruitment;Modeling;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Outcome Assessment;Outcome Measure;Output;Parents;Participant;Pathway interactions;patient engagement;patient portal;Patient Recruitments;Patient Self-Report;Patients;Pediatric Hospitals;Peer Review;Pennsylvania;Perception;Persons;Phenotype;Philadelphia;polygenic risk score;Precision therapeutics;Primary Care;programs;prospective;Protocols documentation;Provider;Publications;Qualifying;Questionnaires;racial minority;Recommendation;Recording of previous events;recruit;repository;Research;Rest;Risk;Risk Assessment;Risk Estimate;Risk Factors;Risk Management;risk perception;Risk Reduction;risk variant;Sampling;Secure;Severities;Severity of illness;Site;Specificity;success;Testing;trait;Underserved Population;United States;Universities;uptake;Validation;whole genome;willingness;Work

PROJECT_TITLE: Utilizing Polygenic Risk to Understand and Improve Outcomes: A Model For Overturning Health Disparities Through Minority-Enriched Genomics Healthcare


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Organ Transplantation;Pediatric;Transplantation

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative: This proposal seeks to create magnetic resonance imaging (MRI)-visible devices for minimally invasive interventional procedures that will help diagnose diseases in the heart wall called cardiomyopathies and treat heart disease to decrease the likelihood of developing heart failure. Extensive testing of an MRI-compatible endomyocardial biopsy device, an MRI-compatible injection catheter, and MRI-compatible pigtail catheter will be performed on the benchtop and in dogs as a model for both pediatric and adult patients. In addition, we will test these devices using a new paradigm for device development in cardiovascular disease by studying spontaneously occurring non-ischemic cardiomyopathies in client-owned dogs, such as Irish Wolfhounds, to provide a more realistic model for translation to human clinical trials using the same whole body MRIs that are also used for patient studies.

PI_NAMEs: KRAITCHMAN, DARA L (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: 3-Dimensional;7 year old;accurate diagnosis;Adult;Adverse event;Affect;Age;American;Angiography;Animal Model;Animals;Biopsy;Blood;Breeding;canine model;Canis familiaris;Cardiac;Cardiac Catheterization Procedures;cardiac device;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;Catheterization;Catheters;Cessation of life;chemotherapy;Child;Childhood;Client;Clinical;Clinical Trials;clinically relevant;Complication;congenital heart abnormality;Consensus;Data;detection method;Development;Device or Instrument Development;Devices;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Imaging;Diagnostic Procedure;Dilated Cardiomyopathy;Disease;disease diagnosis;Echocardiography;Electrocardiogram;Ensure;Epicardium;Etiology;Exposure to;Fluoroscopy;Genetic;Global Change;Goals;Health Care Costs;Heart;Heart Diseases;Heart failure;Heart Transplantation;Heating;hemodynamics;Histopathology;Human;image guided;imaging facilities;Imaging Techniques;Immunologics;improved;in vitro testing;in vivo;Incidence;individual patient;Infection;Inflammation;Injections;Injury;Intervention;Ionizing radiation;Jaw;Left;Left ventricular structure;Life;life span;Magnetic Resonance;Magnetic Resonance Imaging;Measures;Medical;minimally invasive;Modeling;Monitor;mortality;Myocardial;Myocardial Infarction;myocardial injury;Myocarditis;Myocardium;non-invasive imaging;Organ;Patients;Pediatric Cardiomyopathy;pediatric patients;Pericardial body location;pre-clinical;Prevalence;prevent;Primary idiopathic dilated cardiomyopathy;Procedures;Prognosis;Puncture procedure;Radiation;Recommendation;Research Proposals;risk/benefit ratio;Roentgen Rays;Route;Safety;Sampling;Screening procedure;Secondary to;Serious Adverse Event;Side;soft tissue;Solid;Specimen;Stroke;Structure;Techniques;Testing;Therapeutic;Tissues;translation to humans;translational model;Translations;Transplant Recipients;Venous;Ventricular;Ventricular Arrhythmia;Ventricular Dysfunction;Ventricular septum;Visualization;Vulnerable Populations;Waiting Lists;Work

PROJECT_TITLE: MR-compatible Devices for the Diagnosis and Treatment of Cardiomyopathies

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric;Sleep Research

ORG_DEPT: PEDIATRICS

PHR: Project Narrative The current study will systematically disentangle the impact of light exposure from screens from the impact of arousing media content on children’s sleep regulation as well as next-day emotion regulation and executive functioning. Using innovations in the objective assessment of tablet use, we will control for differences in children’s objectively assessed tablet use history. Our findings will have implications that will inform screen media use guidelines for school-age children.

PI_NAMEs: ALFANO, CANDICE A;MORENO, JENNETTE P (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Academy;actigraphy;Address;Adolescence;Adult;adverse outcome;American;Arousal;Beds;Behavior;Child;Childhood;circadian;Cognitive;Cross-Sectional Studies;design;Development;Drowsiness;Electronics;emotion dysregulation;emotion regulation;Emotions;evidence base;Executive Dysfunction;executive function;experimental group;experimental study;Exposure to;falls;Foundations;Goals;Growth;Guidelines;Health;health organization;Heart Rate;heart rate variability;Home;Home environment;Hour;Informal Social Control;innovation;Intuition;Knowledge;Laboratories;Learning;Life;Light;light effects;light emission;Measures;media use;Mediating;Melatonin;Mental disorders;neurocognitive test;novel;Obesity;Parents;pediatrician;Pediatrics;Performance;Phase;Physiological;Physiology;Policies;poor sleep;prepuberty;Protocols documentation;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;Reporting;Research;Research Methodology;Risk Taking;Role;saliva sample;School-Age Population;screening guidelines;secondary outcome;Sleep;Sleep disturbances;sleep health;sleep onset;sleep pattern;sleep quality;sleep regulation;suicidal;Tablets;Testing;Time;Translating;virtual

PROJECT_TITLE: Experimental effects of light and content from evening screen media use on children's sleep, executive functioning, and emotion regulation

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Narrative The purpose of this renewal application is to continue and refocus the work of the Health Delivery Systems Center for Diabetes Translational Research (HDS-CDTR) (P30 DK092924), renamed the Diabetes Research for Equity through Advanced Multilevel Science Center for Diabetes Translational Research (DREAMS- CDTR), on reducing diabetes related health disparities and improving health equity. Refocused on northern California and its Central Valley, the DREAMS-CDTR is a collaborative partnership between the Kaiser Permanente Northern California’s Division of Research and the University of California at San Francisco, Merced and Davis. This Center leverages expertise in two Core Translational Research areas of health equity and methods and data integration and from a national diabetes policy resources core to accelerate the translation of diabetes research into changes in healthcare delivery, public health practice, and policy.

PI_NAMEs: ADAMS, ALYCE SOPHIA;SCHMITTDIEL, JULIE A (contact);SELIGMAN, HILARY KESSLER

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: Acceleration;Area;Attention;base;California;care delivery;career;career development;Caring;Clinical;Clinical Research;Communication;Communities;community partners;community setting;comparative effectiveness;Complex;Complications of Diabetes Mellitus;cost;Cost Effectiveness Analysis;COVID-19 pandemic effects;Data;data integration;design;Development;diabetes control;Diabetes Mellitus;diabetes risk;Disparity;Dreams;Epidemic;Equity;ethnic minority;ethnic minority population;evidence base;experimental study;Faculty;Family;food insecurity;Fostering;Foundations;Funding;Future;Grant;Health;health care delivery;health communication;health disparity;health economics;health equity;health equity promotion;Health equity research;health inequalities;Health Policy;Health Services Accessibility;Health system;Healthcare Systems;high risk;Improve Access;improved;Individual;Inequity;innovation;Institution;Intervention;Intervention Studies;Low income;low socioeconomic status;Machine Learning;medication compliance;member;Methods;Minority Groups;models and simulation;multidisciplinary;Names;National Institute of Diabetes and Digestive and Kidney Diseases;Natural experiment;Non-Insulin-Dependent Diabetes Mellitus;novel;Observational Study;older adult;Outcome;Paper;Pattern;Persons;Policies;Policy Making;Policy Research;Population Heterogeneity;Prevalence;programs;Public Health;Public Health Practice;Publishing;racial minority;Recording of previous events;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;Rural;Rural Population;San Francisco;scaffold;Science;Scientist;service organization;Site;Social Environment;Social Policies;support network;System;systems research;Target Populations;telehealth;therapy design;Translating;translational health science;Translational Research;Translations;United States Dept. of Health and Human Services;Universities;Vulnerable Populations;Work

PROJECT_TITLE: the Diabetes Research for Equity through Advanced Multilevel Science Center for Diabetes Translational Research (DREAMS-CDTR)


NIH_SPENDING_CATS: Diabetes

PI_NAMEs: ADAMS, ALYCE SOPHIA (contact)

PROJECT_TERMS: Advisory Committees;Collaborations;Consultations;Diabetes Mellitus;Dreams;Ensure;Equity;Faculty;Maintenance;member;National Institute of Diabetes and Digestive and Kidney Diseases;Productivity;programs;recruit;Research;Resources;Role;Science;Scientist;Translational Research;Update;web site

PROJECT_TITLE: DREAMS - Admin Core


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Health Services;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Early treatment of autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) can improve long-term outcomes, but only when at-risk children are identified promptly and accurately. Early risk factors common to both conditions (e.g. premature birth, perinatal complications) are collected during routine care and are accessible in the electronic health record (EHR), but have not been used at scale to stratify risk or improve early screening. The proposed study will develop improved methods and machine learning models for predicting ASD and ADHD based on EHR data available early in child development, then take critical steps toward clinical use by prospectively evaluating these models, deploying them in the Duke University Health System EHR, and working with providers to develop and evaluate a comprehensive ASD and ADHD risk prediction dashboard to inform clinical decision-making.

PI_NAMEs: ENGELHARD, MATTHEW MORROW (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Academic skills;Address;Affect;Age;Area;Attention deficit hyperactivity disorder;autism spectrum disorder;career;career development;Child;Child Development;Childhood;Clinical;clinical decision-making;clinically actionable;Code;Communication;Costs and Benefits;dashboard;Data;Data Element;data pipeline;Data Science;Databases;design;Development;Development Plans;Diagnosis;diagnosis design;disorder risk;Disparity population;Early identification;Early Intervention;early screening;Early treatment;Electronic Health Record;Equity;Evaluation;Event;Focus Groups;follow-up;Friends;Goals;Health;health data;Health system;improved;innovation;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Intervention;Length;Low Prevalence;Machine Learning;machine learning method;machine learning prediction;Measures;Mental Health;Mentored Research Scientist Development Award;Mentors;method development;Methods;model development;model of autism spectrum disorder;Modeling;National Institute of Mental Health;novel;Outcome;Patients;Pattern;Performance;perinatal complications;predictive modeling;Premature Birth;Primary Care;Probability;Procedures;programs;prospective;prototype;Provider;Research;Research Support;Risk;Risk Factors;risk prediction;risk prediction model;risk stratification;ROC Curve;routine care;screening;Secure;Services;Source;System;Time;Training;Translating;Universities;Update;usability;Work

PROJECT_TITLE: Machine Learning Methods to Develop and Deploy Real-Time Risk Surveillance for Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder from the Electronic Health Record

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

PROJECT_TERMS: Address;Affect;Area;California;care delivery;Caring;Clinical;Communities;community organizations;Consultations;coronavirus pandemic;design;Diabetes Mellitus;Discrimination;Disparity;Dreams;economic implication;Environment;Equity;ethnic diversity;Exhibits;Foundations;Funding;Generations;Goals;Health;health care delivery;health care disparity;health disparity;health economics;health equity;health equity promotion;Health equity research;health inequalities;health literacy;Health Policy;Health Promotion;Health system;Healthcare;Healthcare Systems;Income;Inequality;Inequity;innovation;Institutional Policy;Institutional Practice;interest;Intervention;Intervention Studies;Knowledge;Medical;medication compliance;member;Methods;Mission;Monitor;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Observational Study;operation;Policies;Population Heterogeneity;programs;Public Health;Public Policy;Publications;Publishing;Race;Research;Research Personnel;Research Project Grants;Role;Rural;San Francisco;Science;Self Management;Site;social;social health determinants;social media;Social Policies;Social Work;Societies;structural health determinants;Structural Racism;System;translational health science;Translational Research;translational scientist;Translations;Vulnerable Populations

PROJECT_TITLE: DREAMS - Translational Research Core - Health Equity & Action Translational (HEAT)


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

PI_NAMEs: KARTER, ANDREW JOHN (contact)

PROJECT_TERMS: Acceleration;analytical method;Area;Artificial Intelligence;bench to bedside;Biological Markers;care delivery;care systems;Caring;causal model;Clinical;Clinical Services;Community Health;community intervention;community partners;comparative effectiveness;comparative effectiveness analysis;Cost Effectiveness Analysis;Data;Data Collection;data integration;data resource;Data Sources;deprivation;design;Development;Diabetes Mellitus;Diabetes prevention;diabetes risk;Diffusion;Disparity;Dreams;Engineering;English Language;Ensure;Environment;Equity;Ethnic Origin;Evaluation;evidence base;experimental study;Faculty;Funding;Generations;Goals;Health;health data;health disparity;health economics;health equity;health equity promotion;health inequalities;health literacy;Health Policy;Health Services Research;Health system;Healthcare Systems;implementation science;improved;Individual;Inequality;innovation;Intervention;Intervention Studies;Knowledge;life span;Machine Learning;Mentors;Methodology;Methods;Mission;Modeling;models and simulation;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Natural experiment;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;novel;Patients;Policies;Policy Research;Population;population health;Prevention;Public Health;Public Policy;Race;Research;Research Methodology;Research Personnel;Research Project Grants;Risk;risk stratification;Running;Rural;Science;Site;social;Social Policies;Socioeconomic Status;Source;Statistical Methods;System;Techniques;Technology;Testing;translational potential;Translational Research;translational scientist;Translations;uptake;Vulnerable Populations

PROJECT_TITLE: DREAMS Translational Core - Methods and Data Integration (MDI)