NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Radiation Oncology

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Washington University Paul Calabresi K12 Career Development Award for Clinical Oncology Project Narrative: Washington University Paul Calabresi Oncology K12 Program aims to train a new generation of clinicians in genetics/genomics, translational medicine, patient centered outcomes research, and cancer immunology and cellular therapy in order to improve the outcomes for cancer patients.

PI_NAMEs: DIPERSIO, JOHN F.;GOVINDAN, RAMASWAMY  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: anti-cancer research;Appointment;cancer clinical trial;cancer genomics;career development;Cell Therapy;Clinical Oncology;Clinical Research;Clinical Trials;design;Discipline;Doctor of Pharmacy;Doctor of Philosophy;Educational Curriculum;Eligibility Determination;Evaluation;experience;Faculty;Funding;Goals;Gynecologic Oncology;hands on research;Health;Healthcare;Human;improved;investigator training;K-Series Research Career Programs;Lead;Malignant Neoplasms;Medical Oncology;Mentored Clinical Scientist Development Program;Mentors;Monitor;Nurses;Outcome;Outcomes Research;patient oriented;patient oriented research;Patient-Focused Outcomes;Pediatric Oncology;Phase;Positioning Attribute;Program Development;Radiation Oncology;Research;Research Personnel;Research Training;Scientist;Surgical Oncology;Therapeutic Clinical Trial;Training;training opportunity;translational medicine;tumor immunology;Universities;Washington

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: Nashville

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Most cancer patients do not respond to currently approved immune checkpoint inhibitors, motivating a need for new approaches to stimulate robust and durable immune responses against tumors. This proposal aims to develop and optimize a new class of immunotherapeutic nanotechnology that jump starts natural mechanisms of antitumor immunity. If successful, this approach has potential to increase the number of patients that benefit from cancer immunotherapy.

PI_NAMEs: WILSON, JOHN TANNER (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Address;Affinity;Agonist;Antibodies;Behavior;Biodistribution;Biological;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;cancer therapy;cancer type;CD276 gene;cellular targeting;Circulation;Clinical;clinical translation;Clinical Treatment;clinically relevant;Combination immunotherapy;Cross-Priming;Cytosol;design;Development;Dinucleoside Phosphates;Disease;Drug Delivery Systems;Drug Kinetics;Endosomes;Engineering;Gene Activation;Generations;Goals;Half-Life;Immune;immune activation;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;immune resistance;Immune response;immunoengineering;immunogenicity;Immunologic Memory;Immunooncology;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;Infiltration;innovation;insight;Intravenous;intravenous administration;Investigation;Ligands;Lipids;Melanoma;Minority;Modeling;Molecular;multidisciplinary;Mus;Myeloid-derived suppressor cells;nanocarrier;nanoparticle;Nanotechnology;Natural Immunity;Nature;new combination therapies;novel;novel strategies;Pathway interactions;Patients;Periodicity;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;phosphoric diester hydrolase;Polymers;Population;Positioning Attribute;preclinical development;Prodrugs;Property;Publishing;rational design;recruit;Recurrent disease;Regimen;Research;research clinical testing;Resistance;resistance mechanism;response;restraint;Route;Science;Sentinel Lymph Node;small molecule inhibitor;Stimulator of Interferon Genes;Structure;Structure-Activity Relationship;success;T-cell inflamed;T-Lymphocyte;targeted treatment;Therapeutic;therapeutic target;Therapeutic Uses;Toxic effect;Treatment Efficacy;treatment response;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor-infiltrating immune cells;Up-Regulation;uptake;Vesicle

PROJECT_TITLE: Expanding the Therapeutic Window of Nanoparticle STING Agonists for Cancer Immunotherapy

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PI_NAMEs: TRAYNOR, JOHN R. (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Absence of pain sensation;Acute Pain;addiction;addiction liability;Affinity;Agonist;Allosteric Site;Amino Acids;Analgesics;antagonist;antinociception;Arrestins;Behavior;Behavioral;Binding;Binding Sites;Characteristics;Chemicals;Chemistry;Chronic;chronic pain;Clinical;Collaborations;Computing Methodologies;Constipation;Coupled;Coupling;Cryoelectron Microscopy;Cyclic AMP-Dependent Protein Kinases;Data;density;Development;diverse data;drug action;Drug Design;drug development;Effectiveness;endogenous opioids;Enkephalins;Epidemic;experimental study;Exposure to;extracellular;Funding;Future;G protein coupled receptor kinase;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;improved;In Vitro;in vivo;Instruction;Knowledge;Ligands;Methionine Enkephalin;Modeling;models and simulation;Molecular;Morphine;mu opioid receptors;Mus;Mutate;Nausea and Vomiting;neurotransmission;novel;Opioid;Opioid agonist;Opioid Analgesics;Opioid Antagonist;opioid epidemic;Opioid Peptide;Opioid Receptor Binding;Opioid Rotation;Oxycodone;Pain Clinics;pain relief;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphotransferases;positive allosteric modulator;preservation;Property;receptor;Receptor Activation;receptor function;recruit;Regulation;relapse prevention;respiratory;response;Role;Side;side effect;Signal Transduction;Site;small molecule;structural biology;Structure;System;Testing;Translating;translational potential;Transmembrane Domain;Ventilatory Depression;Work

PROJECT_TITLE: Allosteric Modulation of the Mu-Opioid Receptor

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: NARRATIVE This project develops computer programs that can predict how different potential therapies change the way that a patient's heart will grow and adapt. The long-term goal is to create software that cardiologists can use to optimize therapies for patients who have heart failure.

PI_NAMEs: CAMPBELL, KENNETH S (contact);LEE, LIK CHUAN ;WENK, JONATHAN F

PROGRAM_OFFICER_NAME: SHANBHAG, SUJATA MADHUKAR

PROJECT_TERMS: Algorithm Design;algorithm development;algorithm training;Algorithms;Area;Artificial Intelligence;Atrial Fibrillation;Baroreflex;Biophysics;blood pressure control;blood pump;Cardiac;Cardiology;Cardiovascular system;Caring;Circulation;Clinical;clinical care;Clinical Data;Computer Models;computer program;Computer software;constriction;Data;Development;Devices;Dimensions;Doctor of Philosophy;Echocardiography;EFRAC;Elements;Engineering;Enrollment;Foundations;Future;Geometry;Goals;gradient boosting;Growth;Heart;Heart failure;improved;innovation;Interdisciplinary Study;Intervention;Kentucky;laptop;Left ventricular structure;Machine Learning;Magnetic Resonance Imaging;Manuscripts;Microfilaments;Modeling;Molecular;Myocardial;Myosin ATPase;novel therapeutic intervention;optimal treatments;outcome prediction;Paper;Patient-Focused Outcomes;Patients;Physiological;Physiology;Positioning Attribute;pressure;Pulmonary artery structure;random forest;randomized, clinical trials;Recommendation;Reflex action;Registries;Research;Research Personnel;research vision;response;Rewards;Running;Science;Scientist;Signal Transduction;simulation;skills;standard care;Stress;Structure;success;Swarm intelligence;System;Techniques;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;Thick;Time;treatment optimization;Universities;Ventricular;ventricular assist device;wireless transmission

PROJECT_TITLE: Data-driven optimization of therapy for heart failure

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed study aims to uncover the plasticity of postmitotic cells in mammalian retina. We will focus on understanding how zinc finger transcription factor Myt1 promotes neuronal fates in newly born postmitotic cells during development and determining whether Myt1 can enhance neuronal reprogramming in mature retina. This work will improve our understanding of the retina and provide new candidate genes and possibilities for the regeneration of retinal neurons.

PI_NAMEs: WANG, SUI  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Adult;Binding;Biology;Candidate Disease Gene;cell fate specification;Cell Reprogramming;cell type;Cells;Data;Defect;Development;developmental disease;Disease;Down-Regulation;Ectopic Expression;Electroporation;Embryo;Ensure;Family;Functional disorder;gain of function;Genes;genetic approach;Gliosis;Human;improved;in vivo;Interneurons;Light;loss of function;member;Methods;Microphthalmos;Microscopy;Mitotic;Muller's cell;Mus;Mutation;Myelin;Neonatal;neurogenesis;Neuroglia;Neurons;Notch Signaling Pathway;novel;Pathway interactions;plasmid DNA;Play;postmitotic;postnatal;Production;programs;Promoter Regions;Proteins;Publishing;regenerative therapy;Repression;Retina;Retinal Diseases;retinal neuron;retinal progenitor cell;retinal regeneration;Role;single-cell RNA sequencing;spine bone structure;Stereotyping;Testing;Therapeutic;Titrations;tool;transcription factor;Work;Zinc Fingers

PROJECT_TITLE: Mechanisms regulating the plasticity of postmitotic cells in mammalian retina

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative Blockade of CD154 is a highly effective method of inducing transplantation tolerance (a state in which transplant recipients would no longer require toxic immunosuppression), however clinical translation of CD154 blockers has met with many challenges, and as an alternative reagents that block CD40 (the receptor for CD154) were tested in recent clinical trials. However, CD40 blockers have proved to be not as effective as CD154 blockers, and here we have identified a novel molecular interaction that explains this discrepancy. Here, we will test innovative strategies to block these residual interactions and thus optimize the use of CD40 blockers to promote transplant tolerance in the clinic.

PI_NAMEs: FORD, MANDY L (contact)

PROJECT_TERMS: Acceleration;Allogenic;allograft rejection;Allografting;Alternative Therapies;American;antagonist;Anti-CD40;Architecture;Attenuated;Binding;Biological;Biomedical Engineering;Cancer Center;CD8-Positive T-Lymphocytes;Cells;Clinic;clinical development;Clinical Research;clinical translation;Clinical Trials;Communication;cytokine;Data;early phase clinical trial;Event;experimental study;FOXP3 gene;Frequencies;Generations;Immune;immune cell infiltrate;immunoregulation;Immunosuppression;in vivo;Inferior;Infiltration;inhibitor;innovation;Integrins;isoimmunity;ITGAM gene;ITGB2 gene;Journals;Kidney Transplantation;Ligands;Lilium;Macrophage;Macrophage-1 Antigen;Methods;Modeling;Monoclonal Antibodies;monocyte;mouse model;Mus;Myelogenous;nanoparticle;Nanotechnology;nanotherapeutic;Nature;nonhuman primate;novel;Outcome;Paper;Pathway interactions;Peptides;peptidomimetics;preclinical study;prevent;Production;Publishing;Reagent;receptor;Regulatory T-Lymphocyte;Reporting;Residual state;Role;Signal Transduction;Specificity;synergism;T cell infiltration;T cell response;T-Lymphocyte;Techniques;Testing;Therapeutic;therapeutic nanoparticles;therapeutic target;Thrombophilia;TNFRSF5 gene;TNFSF5 gene;transcriptome;transcriptomics;Transfusion;Translating;transplant model;Transplant Recipients;Transplantation;Transplantation Tolerance

PROJECT_TITLE: Nanotechnology Targeting Novel CD154:CD11b Interactions for Transplant Tolerance


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative Substance use disorders (SUD) are heritable and facilitated by a host of brain-based mechanisms. These mechanisms, their neural correlates and genetic underpinnings, are increasingly being investigated in the context of large consortium efforts using novel technologies including genomics and neuroimaging. Leveraging such data at scale to address questions in addiction science is a challenge that this mixed predoctoral/postdoctoral training program will rise to meet through a central focus on neurobehavioral measures, genetically informative designs, and cutting edge quantitative methods to uncover and characterize neurobehavioral mechanisms in the development of addiction.

PI_NAMEs: LUCIANA, MONICA  (contact);VRIEZE, SCOTT IAN

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TITLE: Training in genetic and neurobehavioral mechanisms of addiction


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative: The proposed research is relevant to public health because a detailed understanding of the role of autophagy in esophageal epithelial renewal and basal cell homeostasis will fundamentally advance the fields of epithelial biology and mucosal defense. These findings will provide a platform for new avenues of translational applications for therapy in eosinophilic esophagitis. Thus, the proposed research is relevant to the NIH's mission that pertains to developing fundamental knowledge that will help to reduce the burden of human diseases.

PI_NAMEs: NAKAGAWA, HIROSHI  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: 3-Dimensional;Affect;Antioxidants;Autophagocytosis;Basal Cell;Basal Cell Hyperplasia;Biology;Biopsy;Cell Fate Control;Cell Lineage;Cells;Cellular biology;Cellular Stress;Chronic;Clinical;Clonal Expansion;Coupled;CRISPR/Cas technology;cytokine;Data;Defect;Defense Mechanisms;Desmosomes;Development;Disease;Dose;Down-Regulation;Drug Targeting;drug testing;Eosinophilic Esophagitis;Eosinophilic Infiltrate;Epithelium;Esophageal Diseases;Esophageal Stenosis;Esophageal Tissue;Esophagitis;Esophagus;Event;experimental study;Fibrosis;Flow Cytometry;food allergen;Gastroesophageal reflux disease;Genetic;Genetically Engineered Mouse;Growth;Homeostasis;Human;human disease;Immune;Impairment;Inflammation;Inflammatory;inflammatory milieu;innovation;insight;Interleukin-13;keratinocyte;Knowledge;Label;Laboratories;Lamina Propria;Link;Mediating;Mediator;Microscopy;Mission;Mitochondria;Mitochondrial DNA;Modeling;mouse model;Mucous Membrane;Mus;Nature;notch protein;novel;Organoids;Oxidative Stress;Pathogenesis;Patients;Peptic Esophagitis;pharmacologic;postmitotic;Proliferating;Proteins;Public Health;Publications;Quality of life;Radiation;Reactive Oxygen Species;Research;Role;self-renewal;Signal Transduction;Squamous Epithelium;Stratified Squamous Epithelium;Stress;Tamoxifen;Testing;Tight Junctions;Tissues;translational applications;United States National Institutes of Health;Validation

PROJECT_TITLE: Autophagy and esophageal tissue remodeling in EoE

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_CITY: TUCSON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: African Americans have a higher incidence rate of colorectal cancer and colorectal cancer diagnosed before age 50 constitutes over 15% of all colorectal cancers diagnoses—a major cancer health disparity. We have discovered a subtype of colorectal cancers that lack mutation in the APC gene that is associated with earlier ages of diagnosis and a novel epigenetic signature that impacts cancer stem cell maintenance. We will characterize the DNA methylation and transcriptomic signatures and interrogate with genetic and chemical perturbations the pathway-specific vulnerabilities of this subtype, leading to the identification of gene targets and enabling development of precision-medicine approaches to earlier age of onset colorectal cancers in African Americans.

PI_NAMEs: ELLIS, NATHAN A. (contact);LLOR, XAVIER

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: African American;African American population;Age;Age of Onset;Algorithms;APC gene;APC mutation;Automobile Driving;cancer cell;cancer diagnosis;cancer health disparity;Cancer Model;cancer stem cell;cancer subtypes;carcinogenesis;Cell Maintenance;Cells;Chemicals;Chicago;Chromosomal Stability;chromosome mutation;Clinical;Colorectal Cancer;Data;Dependence;Development;Diagnosis;diagnostic biomarker;differential expression;Disparity;DNA Methylation;drug sensitivity;early onset colorectal cancer;Epidemiology;Epigenetic Process;Epithelium;Exhibits;Gene Deletion;Gene Expression;gene regulatory network;Gene Targeting;Genes;Genetic;genomic profiling;Genomics;Goals;high dimensionality;Image;Incidence;innovation;Knowledge;Latino Population;Malignant Neoplasms;Methylation;Microsatellite Repeats;Modeling;Molecular;molecular subtypes;mortality;Mutation;mutational status;Not Hispanic or Latino;novel;Organoids;Outcome;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Population;precision medicine;predictive marker;prevent;Public Health;Race;response;Series;small molecule libraries;Somatic Mutation;stem;stem cells;Subgroup;System;Testing;transcriptomics;tumor;Tumor Suppressor Genes;WNT Signaling Pathway

PROJECT_TITLE: Epigenetic dysregulation in APC-negative colorectal cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Z(55)R]


ADMINISTERING_IC: AG

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Alzheimer's disease (AD) and related dementias (ADRD), for which no effective therapy exists, affect millions of people in the US, cost hundreds of billions of dollars in caregiving expenses, and are a source of important racial and ethnic disparities. Education and lifestyle contribute to these disparities, and this project will clarify how genetic factors may also be involved through the application of three novel tools to study mitochondrial genetic variation: 1) mitochondrial genome-wide association studies (MiWAS), 2) mitochondria-wide gene and environment (GxE) interaction scans (MiWIS), and 3) mito-transcriptomics. The proposed analyses will help explain ethnic differences in AD risk and guide immediate diagnostic insights, targeted lifestyle interventions, and novel therapeutic target identification.

PI_NAMEs: COHEN, PINCHAS  (contact);CRIMMINS, EILEEN M

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: Affect;African American population;Age Years;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer's disease therapeutic;Amino Acid Sequence;Amyloid beta-Protein;Animal Experiments;Attenuated;Bioinformatics;Blood Glucose;Body mass index;Brain;caregiving;Clinical;clinical diagnosis;clinical predictors;Cognition;cognitive function;cohort;cost;Data;Dementia;design;Diabetes Mellitus;Diagnostic;differential expression;disease phenotype;Disparity;DNA;Education;effective therapy;Encephalitis;Environment;Environmental Risk Factor;ethnic difference;ethnic disparity;ethnic diversity;Ethnic Origin;Ethnic Population;Exhibits;gene environment interaction;Gene Expression;gene interaction;Genes;Genetic;genetic analysis;genetic association;Genetic Variation;genome wide association study;genome-wide;genomic tools;Health and Retirement Study;High Fat Diet;Hispanic Populations;Human;humanin;Impaired cognition;improved;Individual;Initiator Codon;insight;Leukocytes;Life Style;lifestyle factors;lifestyle intervention;Measures;Meta-Analysis;Metabolic;Metabolic Diseases;Mitochondria;Mitochondrial DNA;mitochondrial genome;multi-ethnic;Mus;Nature;Neurodegenerative Disorders;neuroprotection;new therapeutic target;Not Hispanic or Latino;novel;Nuclear;Obesity;Participant;Peptides;Persons;Physical activity;Population;Prefrontal Cortex;Prevalence;Process;Publishing;racial disparity;racial population;Reasons for Geographic And Racial Differences in Stroke;Reporting;Running;Scanning;Single Nucleotide Polymorphism;Source;Testing;therapeutic target;Tissues;tool;transcriptome sequencing;transcriptomics;Translating;United States;Variant;Weight Gain

PROJECT_TITLE: Ethnic-specific Effects of Mitochondrial DNA Variants and Environmental Factors on Cognitive Functioning and Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(56)R]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The advancement of biomedical research critically relies on training the next generation of scientists. The goal of the Northwestern University Postbaccalaureate Research Education Program is to recruit trainees from diverse, underrepresented groups and prepare them for a successful transition into graduate school in the biomedical sciences and to help guarantee their success in obtaining the PhD degree. The program features core research, communication skills instruction, and coursework, in addition to a broad range of opportunities within the life sciences PhD and affiliated institutional training (T32) programs, allowing for individualized experiences that will foster personal, scientific and professional growth.

PI_NAMEs: ACOSTA, ANA MARIA  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Acclimatization;Admission activity;Advisory Committees;Area;Behavioral;Biochemistry;Biological Sciences;Biomedical Computing;Biomedical Engineering;Biomedical Research;biomedical scientist;Biomedical Technology;Biophysics;Cell Physiology;Cellular biology;Chicago;Clinic;cohort;Collaborations;Communication;Communities;community building;Complement;Country;Critical Thinking;Data Analyses;design;Development;Development Plans;Developmental Biology;Doctor of Philosophy;Education;education research;Educational process of instructing;Educational workshop;Environment;Event;experience;Faculty;faculty mentor;Fostering;Funding;Generations;Genetic;Goals;graduate school;graduate school preparation;graduate student;Growth;Hispanic Americans;Illinois;Individual;Infrastructure;Institution;Instruction;Intellectual Interest;interest;Interview;Joints;Laboratory Research;Leadership;Learning;matriculation;Mentors;Mexican Americans;Michigan;Mind;minority student;Molecular;Molecular Biology;Molecular Genetics;National Institute of General Medical Sciences;Native Americans;Neurosciences;next generation;Pharmacology;Physiology;Postbaccalaureate;Postdoctoral Fellow;Preparation;Process;Program Evaluation;programs;recruit;Research;Research Personnel;Research Technics;Research Training;Scholars Program;Schools;Science;Scientist;Services;skills;social;Societies;Structure;student mentoring;Students;success;supportive environment;symposium;System;Training;Training and Education;training opportunity;Training Programs;undergraduate student;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Work;Writing

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Natural killer cells (also known as NK cells) are a type of white blood cell that can target and kill cancer cells and virally infected cells; however, their functions are dysregulated during HIV infection allowing HIV-infected cells to evade their surveillance. The functions of these NK cells are hindered when a carbohydrate-binding protein called Siglec-9, expressed on their surface, binds to specific carbohydrates expressed on the surface of their target (HIV-infected) cells. We developed a novel approach to prevent this binding and thereby enhance the NK cells' ability to target and kill HIV-infected cells; this approach can be used in conjugation with other approaches to cure HIV infection.

PI_NAMEs: ABDEL MOHSEN, MOHAMED  (contact);XIAO, HAN

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Antibodies;antiretroviral therapy;Autologous;Binding;Binding Proteins;Blocking Antibodies;Blood;Breast Cancer Cell;Breast Cancer Model;cancer cell;carbohydrate binding protein;carbohydrate receptor;Carbohydrates;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell model;Cell surface;Cells;Chromium;cytotoxic;cytotoxicity;Data;DNA;Enzymes;Exhibits;FCGR3B gene;glycosylation;Goals;Hand;HIV;HIV Infections;Human;humanized mouse;Immune;immune checkpoint;Immune Evasion;Immunologic Surveillance;Immunology;In Vitro;in vivo;Individual;interdisciplinary approach;Interleukin-15;Leukocytes;Ligands;Longevity;Malignant Neoplasms;Mediating;mouse model;Mutate;Natural Killer Cells;Nature;Neuraminidase;neutralizing antibody;novel;novel strategies;perforin;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;pilot test;Polysaccharides;Population;prevent;Productivity;programmed cell death protein 1;receptor;restraint;RNA;Role;sialic acid binding Ig-like lectin;Sialic Acids;Sorting;Spleen;Surface;T-Lymphocyte;Testing;Time;Trastuzumab;tumor;Viral;Viral Physiology;viral rebound

PROJECT_TITLE: Targeting Siglec-9/Sialoglycan Interactions to Enhance NK Functions During HIV Infection

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative/Relevance Hypertension is a growing epidemic condition that afflicts a third of the US population. We have identified the E3 ubiquitin ligase adaptor FBXL13 that interacts with the Na/K/2Cl co-transporter (NKCC2) which is associated to hypertension, but the function of this E3-ubiquitin ligase remains unclear. This proposal will elucidate the effect of high salt diet on the mechanism by which the E3 ubiquitin ligase adaptor FBXL13 regulates NKCC2- dependent NaCl reabsorption which, may lead to new strategies for the treatment of hypertension and promote the development of specific loop diuretics.

PI_NAMEs: ARES-SARMIENTO, GUSTAVO R (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: absorption;Animal Model;Apical;Atrial Natriuretic Factor;Biochemistry;Blood Pressure;blood pressure elevation;Blood Pressure Monitors;blood pressure regulation;Cardiovascular Physiology;career development;Collaborations;Complex;Consumption;CUL1 gene;Cullin Proteins;Cyclic GMP;Data;Development;Development Plans;Diuretics;Doctor of Philosophy;Environment;Epidemic;Excess Dietary Salt;Excretory function;experience;Extramural Activities;F Box Domain;Family;Functional disorder;Funding;Genomics;Goals;Grant;Health system;high salt diet;Human;Hypertension;hypertension treatment;Immunoprecipitation;Impairment;improved;inhibitor;insight;interest;Intervention;Journals;Kidney;Knockout Mice;Knowledge;Leucine-Rich Repeat;Limb structure;liquid chromatography mass spectrometry;Manuscripts;Mediating;meetings;member;Mentors;multicatalytic endopeptidase complex;Mus;Nephrons;Nitric Oxide;novel;novel therapeutic intervention;Patients;pharmacologic;Physiology;Play;Population;prevent;professor;programs;Proteins;Proteomics;Records;Regulation;Research;Research Personnel;Research Project Grants;Research Training;Role;salt sensitive hypertension;saluretic;Scientist;Second Messenger Systems;side effect;skills;Sodium Chloride;Structure of ascending limb of Henle's loop;Surface;symporter;System;Teacher Professional Development;Testing;Thick;Time;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;United States National Institutes of Health;Water;Writing

PROJECT_TITLE: Role of the ubiquitin Ligase adaptor FBXL13 on Salt-sensitive hypertension

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Biomedical Imaging;Lung;Precision Medicine;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Acute lung injury (ALI), known clinically as acute respiratory distress syndrome (ARDS), is a severe and potentially fatal condition with distinct sub-phenotypes associated with different clinical outcomes. Molecular imaging of the recently discovered chemokine receptor/chemokine ChemR23/chemerin axis is a promising approach to non-invasively determine and characterize ALI endotypes. This proposal will focus on the development ChemR23/chemerin targeting positron emission tomography tracers and validation of their potential to non-invasively track the ongoing lung inflammation in a mouse model of ALI.

PI_NAMEs: MANNES, PHILIP ZACHARY (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Affinity;Agonist;Alveolar;antagonist;Asthma;Automobile Driving;Binding;Biochemical;Biological;Biological Markers;Biopsy;Bronchoalveolar Lavage;C-terminal;cell motility;Cells;chemokine;chemokine receptor;Chemotactic Factors;Chronic Obstructive Pulmonary Disease;Clinical;clinical practice;clinical prognostic;CMKLR1 gene;Complex;Critical Illness;Dendritic Cells;design;Detection;Development;Disease;Epithelial Cells;Exhibits;extracellular;fluorodeoxyglucose;Fright;Functional disorder;G-Protein-Coupled Receptors;Gases;Goals;Histologic;Image;imaging biomarker;imaging probe;Immune;immune activation;immunomodulatory therapies;Impairment;improved;in vivo imaging;indexing;Individual;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;Inflammatory Response;Injury;Kinetics;Life;Lipopolysaccharides;Lung;Lung Diseases;lung injury;Macrophage;Measures;Mediating;Methods;migration;Modification;molecular imaging;Monitor;mouse model;Natural Killer Cells;neutrophil;Neutrophil Infiltration;Non-Invasive Detection;non-invasive imaging;novel;Outcome;Pathogenicity;Patients;Peptide Hydrolases;Peptides;peptidomimetics;personalized medicine;Phase;Phenotype;Plasma;Play;Population;Positron-Emission Tomography;precision medicine;Preparation;Process;prognostic;prognostic tool;Property;Proteolytic Processing;prototype;Pulmonary Inflammation;Quality of life;Radiolabeled;radiotracer;receptor;Research;Resolution;Risk;Serine Protease;Serum;Site;smoke inhalation;Specificity;Tail;Tissues;Tracer;uptake;Validation;Visualization

PROJECT_TITLE: Molecular Imaging of the ChemR23-Chemerin Axis in Acute Lung Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-P(20)L]


NIH_SPENDING_CATS: Genetics

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative We will assess the role of protein synthesis in tissue resident macrophages and its impact on macrophage function. Our findings not only have direct impacts on mRNA translation field, but also may provide a framework to study translational control in tissue specific functions of macrophages in other context such as cancer.

PI_NAMEs: TAHMASEBI, SOROUSH  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: activating transcription factor 4;Address;Adhesives;Adopted;Affect;Amino Acids;Animal Model;Apoptosis;Binding Proteins;Biochemical;biological adaptation to stress;Biomedical Engineering;Bone Marrow;Candidate Disease Gene;Cardiac;Cell Physiology;cell type;Cells;Chicago;ChIP-seq;Collaborations;Consultations;Data;Defect;Development;Disease;EIF-2alpha;Erythroblasts;Erythrocytes;Erythroid;Erythrophagocytosis;Erythropoiesis;Eukaryotic Initiation Factors;experience;experimental study;Fetal Liver;Gene Expression;gene network;Genes;Genetic Transcription;genome-wide;Goals;Heme;High Fat Diet;Homeostasis;human disease;In Vitro;in vivo;Inflammatory;inhibitor;innovation;invention;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Letters;Life Cycle Stages;Link;Macrophage;Malignant Neoplasms;Mammalian Cell;mechanical force;Mechanical Stress;Mediating;Memory;Messenger RNA;Modeling;Molecular;mouse model;mRNA Translation;Mus;novel;Nutrient;pathogen;Pathologic;Pathway interactions;Phagocytes;Phagocytosis;Phosphorylation;Phosphotransferases;Physiological;Piezo 1 ion channel;Play;Population Heterogeneity;predictive modeling;Process;Production;programs;Prokaryotic Initiation Factor-2;Protein Biosynthesis;Protein-Serine-Threonine Kinases;Regulation;Resistance;Resolution;response;Ribosomes;Role;Scientist;Seminal;Signal Pathway;Signal Transduction;Stress;Techniques;Technology;Testing;Time;Tissue Engineering;tissue repair;Tissues;transcription factor;Transgenic Mice;Translation Initiation;Translational Regulation;Translations;translatome;Universities;Up-Regulation

PROJECT_TITLE: Translational regulation of tissue resident macrophages by GCN2

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Rehabilitation;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The long-term goal of this project is to test a virtual reality experience designed to reduce drug use and increase abstinence, and increase identification with the future self, future time perspective, and delayed reward choice in persons recovering from stimulant use disorder. Through increasing future orientation and delay-of-reward behavior with a precision medicine personalized experience, the intervention is designed to increase beneficial decision-making and positive future outcomes. The results of this study will provide vital information on the effectiveness and behavioral mechanisms of this adjunctive intervention intended to facilitate recovery outcomes.

PI_NAMEs: OBERLIN, BRANDON  (contact)

PROGRAM_OFFICER_NAME: REICHEL, CARMELA MARIE

PROJECT_TERMS: Abstinence;Address;Aftercare;Age;Attention;Behavior;behavior change;behavior test;Behavior Therapy;Behavioral;behavioral economics;Behavioral Mechanisms;Biometry;Brain;Clinical Psychology;Clinical Trials;community partners;comparison control;craving;Data;Decision Making;design;Development;digital;discounting;drug abstinence;drug efficacy;drug testing;Drug usage;Effectiveness;efficacy evaluation;efficacy testing;efficacy trial;Emotional;endophenotype;Event;Evidence based intervention;Exhibits;experience;feasibility testing;follow-up;Frequencies;Future;Goals;hedonic;Impairment;improved;Individual;Intervention;Interview;Intoxication;Investments;Laboratories;long term recovery;male;medication-assisted treatment;Methods;Motivation;multidisciplinary;neglect;Neuropsychological Tests;non-drug;novel;open label;optimism;Outcome;Participant;Patient Self-Report;Patients;personalized medicine;Persons;Pharmacotherapy;precision medicine;preference;Preparation;randomized, clinical trials;Randomized, Controlled Trials;Recovery;recruit;Relapse;relapse prevention;relapse risk;Resistance;response;Rewards;safety and feasibility;Sampling;Sensory;Signal Transduction;Stimulant;stimulant abuse;stimulant use;stimulant use disorder;Substance abuse problem;Substance Use Disorder;success;successful intervention;sustained recovery;Testing;theories;Thinking;Time;Travel;treatment as usual;Treatment outcome;Validation;virtual;Virtual and Augmented reality;virtual reality;virtual reality environment;virtual reality intervention;virtual world;Visualization;Work

PROJECT_TITLE: Virtual Reality-Augmented Future Orientation in Stimulant Use Disorder Recovery

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE (RELEVANCE) Disruption of circadian rhythms is common in modern life and has been causatively associated with most major human diseases including coronary artery disease, diabetes, obesity, aging, and neuropsychiatric disorders. We propose to investigate the underlying biochemical and cell biological mechanisms by which the circadian timekeeping system adapts to stress to promote cellular resilience. Unveiling the links between the circadian system and cellular stress pathways will define crucial regulatory steps that might herald the identification of novel disease pathways and how the circadian clock modulates vulnerability to them.

PI_NAMEs: LIPTON, JONATHAN OREN (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Affect;Aging;Amino Acids;Animals;ARNTL gene;Articulation;assay development;Behavioral;Behavioral Model;Biochemical;Biochemistry;Biological;biological adaptation to stress;Biology;biophysical properties;Blood specimen;Brain;Cardiovascular Diseases;Cardiovascular system;Cell Line;Cell Physiology;Cells;Cellular biology;cellular resilience;Cellular Stress;Childhood;Chronobiology;circadian;circadian biology;Circadian desynchrony;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical;Clinical Medicine;Clock protein;Collaborations;Compensation;Coronary Arteriosclerosis;Darkness;Data;Data Set;Diabetes Mellitus;Disease;Disease Pathway;Disease susceptibility;Elements;Engineering;Environment;experience;experimental study;Failure;Feedback;Gene Expression;Genes;Genetic Models;Genetic Transcription;Genomics;Goals;Heat-Shock Response;Homeostasis;Human;human disease;Image;individual variation;inhibitor;interdisciplinary approach;interest;knock-down;Knowledge;Laboratories;Life;Light;Link;Liver;Lung Diseases;Maintenance;Maps;Measures;Mediating;Medicine;Metabolic;Modeling;Modernization;Molecular;Molecular Chaperones;molecular clock;Movement;multicatalytic endopeptidase complex;multidisciplinary;Mus;Nervous System Disorder;Neurologist;neuropsychiatric disorder;neuropsychiatry;novel;Obesity;Output;Pathway interactions;Patients;Periodicity;peripheral blood;pharmacologic;Phase;phosphoproteomics;Physical condensation;Physicians;Physiology;Planet Earth;Post-Translational Protein Processing;Predisposition;programs;promote resilience;Protein Biosynthesis;Proteins;Proteome;Proteomics;Reporter;Research;resilience;response;RNA;Role;Secondary to;sensor;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Solubility;Starvation;Stimulus;Stress;stressor;structural determinants;superresolution imaging;System;Temperature;Testing;Therapeutic;Time;Training;transcription factor;Translating;Translations;transmission process

PROJECT_TITLE: Investigating Circadian Mechanisms of Cellular Resilience: Rhythmic Condensates, Disorder, and Stress


NIH_SPENDING_CATS: Biotechnology;Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Genetics;Human Genome;Lung;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE There are significant sex differences in COPD epidemiology and clinical manifestations, however sex-based analyses of genomic data have been limited, neglecting an essential biological variable for advancing precision medicine for lung diseases. We propose integrating X chromosome multi-omic data, X chromosome inactivation patterns, and network analysis to better understand sex-biased regulation of X chromosome genes in COPD susceptibility and heterogeneity. Understanding the X chromosome genetic, epigenetic, and regulatory network features associated with COPD will provide insights into the molecular mechanisms underlying sex differences in COPD susceptibility, emphysema, and lung function, and facilitate future development of sex-aware diagnostics and therapeutics.

PI_NAMEs: LOPES-RAMOS, CAMILA  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Accounting;advanced system;Affect;affection;Age;Alleles;Apoptosis;Award;Awareness;Biological;Biological Process;biological sex;Blood specimen;Childhood Asthma;Chronic Obstructive Pulmonary Disease;Cilia;Clinical;clinical practice;cohort;Communities;comorbidity;Data;Data Analyses;detection method;Development;Diagnosis;Diagnostic;diagnostic development;differential expression;Disease;disease heterogeneity;Disease susceptibility;disorder risk;Epidemiology;Epigenetic Process;epigenetic regulation;Extracellular Matrix;Female;Funding;Future;Gene Dosage;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene regulatory network;Genes;Genetic;Genetic Transcription;genetic variant;Genetic Variation;genome sequencing;genomic data;Genotype;Genotype-Tissue Expression Project;Goals;Health;Heterogeneity;Incidence;Individual;Inflammation;insight;Investigation;K-Series Research Career Programs;Knowledge;Learning;Leukocytes;Link;Lung;Lung Diseases;male;Medicine;Mentored Research Scientist Development Award;Mentors;Methodology;Methods;Methylation;Modeling;Molecular;Molecular Biology;Morphogenesis;Multiomic Data;neglect;Onset of illness;Outcome;Oxidative Stress;Pathogenesis;Pathway Analysis;Pathway interactions;Pattern;Phenotype;precision medicine;Preventive;Process;programs;Pulmonary Emphysema;Pulmonary Fibrosis;pulmonary function;Pulmonology;Quantitative Trait Loci;Regulation;Research;Research Personnel;Resources;respiratory;Sampling;Severities;Severity of illness;sex;sex as a biological variable;Sex Bias;Sex Chromosomes;sex development disorder;Sex Differences;Site;skills;smoking exposure;Structure of parenchyma of lung;study population;Systems Biology;Testing;Therapeutic;Tissues;tool;Training;transcription factor;transcriptomics;treatment response;Validation;Variant;Whole Blood;whole genome;Work;X Chromosome;X Inactivation

PROJECT_TITLE: Sex chromosome gene regulatory networks and COPD


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposal will enhance and disseminate a multi-factorial decision support framework, developed to prioritize genes and variants in cancer. The framework is open source and will be capable of handling large volumes of data. It will simplify and enhance the way that users apply computation to identifying variants whose aberrant function contributes to tumorigenesis, prognosis and therapy selection.

PI_NAMEs: KARCHIN, RACHEL  (contact)

PROJECT_TERMS: Address;Adopted;Adoption;anti-cancer research;Architecture;base;Bioinformatics;cancer genomics;Cancer Patient;cancer subtypes;Characteristics;Clinical;Cloud Computing;cloud platform;Cloud Service;cohort;Collaborations;Collection;Communities;Complex;Computer Analysis;Computer software;computerized tools;Custom;Data;Data Commons;data privacy;Data Set;Databases;design;Disease;DNA Sequence;DNA Sequence Alteration;DNA sequencing;driver mutation;Educational workshop;Ensure;Environment;Epitopes;Evaluation;Feedback;flexibility;Frequencies;Friends;Gene Frequency;Genes;genetic variant;Genomics;genomics cloud;Germ-Line Mutation;graphical user interface;Growth;hackathon;Haplotypes;high throughput analysis;Human;improved;in silico;Individual;informatics tool;interoperability;Investments;Language;Literature;Malignant Neoplasms;Measures;meetings;Molecular;Mutation;Occupations;Online Systems;open source;outreach;parallel processing;Pathogenicity;patient subsets;Population;Prognosis;Property;protein structure;recruit;Recurrence;Research Personnel;Resources;Running;Sampling;Selection for Treatments;Services;Side;skills;social media;Software Tools;Somatic Mutation;Source;Source Code;Subgroup;success;symposium;System;task analysis;Techniques;Time;tool;Training;tumor;Tumor Tissue;tumorigenesis;Untranslated RNA;Update;usability;Variant;Visualization;Visualization software;web server;web-based tool;Work

PROJECT_TITLE: OpenCRAVAT: Informatics Tools for High-Throughput Analysis of Cancer Mutations


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Precision Medicine;Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: The Boston Lung Cancer Survival cohort contains an extensive amount of valuable questionnaire and biologic data that can be leveraged to extend our understanding of the natural history of lung cancer. The combination of biomarkers, tumor molecular characterization, radiomic features, and traditional epidemiologic risk factors in this rich resource enables powerful translational research and provides unique opportunities to explore novel predictors of overall survival and treatment outcomes. With continued support, the Boston Lung Cancer Survival cohort can continue to advance our understanding of the molecular heterogeneity of lung cancer, enabling effective diagnostic and therapeutic strategies that improve the health of individuals diagnosed with lung cancer.

PI_NAMEs: CHRISTIANI, DAVID C (contact)

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TERMS: Address;Adult;Air Pollution;Alternative Therapies;anti-cancer research;Archives;automated image analysis;Award;biobank;bioinformatics infrastructure;Biological;Biological Markers;Boston;built environment;Cancer Center;cancer diagnosis;cancer epidemiology;cancer heterogeneity;Cancer Patient;cancer survival;Cancer Survivor;Cancer Survivorship;cancer therapy;Cessation of life;Chest imaging;Clinical;clinical investigation;cohort;Collaborations;Collection;comorbidity;Creativeness;Dana-Farber Cancer Institute;Data;data management;Data Management Resources;data repository;Databases;Diagnosis;Diagnostic;dietary;Dimensions;Disease Progression;DNA;driver mutation;economic determinant;Education;effective therapy;Electronic Health Record;empowerment;Enrollment;Environment;Environmental Exposure;epidemiologic discoveries;Epidemiologic Methods;Epidemiology;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Epigenetic Process;Erlotinib;Evaluation;follow-up;Funding;Gefitinib;General Hospitals;Genetic;genetic epidemiology;Genomics;genotyped patients;Grant;Health;Health Insurance;Heterogeneity;High Resolution Computed Tomography;Image;Immune checkpoint inhibitor;Immunotherapy;improved;Income;income insurance;indexing;Individual;Infrastructure;innovation;Interdisciplinary Study;International;Investigation;Laboratories;Leukocytes;Libraries;Longterm Follow-up;Lung;Lung Adenocarcinoma;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Massachusetts;Measures;Medical Informatics;Meteorology;method development;Methodology;minority patient;Modeling;Molecular;Monitor;mortality;multidisciplinary;Mutation;mutational status;Natural History;Neighborhoods;new technology;Newly Diagnosed;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;novel therapeutics;Nucleic Acids;Occupational;Oncogenic;Output;Paper;Participant;Pathology;Patients;Peripheral;phenome;phenomics;Phenotype;Plasma;Positron-Emission Tomography;predictive marker;Productivity;prognostic;Prognostic Marker;programs;Publishing;pulmonary function;Pulmonary function tests;Quality of life;Questionnaires;Race;racial disparity;radiomics;Recording of previous events;recruit;repository;Research;Research Personnel;Resource Sharing;Resources;response;Risk Factors;RNA;ROS1 gene;Sampling;segregation;Serum;Smoking;social determinants;Socioeconomic Status;socioeconomics;Source;Specimen;survival outcome;Survivors;targeted treatment;Therapeutic;Tissue Banks;Tissue Microarray;Tissue Survival;Tissues;traditional therapy;translational medicine;Translational Research;treatment disparity;Treatment outcome;treatment response;treatment strategy;Treatment-related toxicity;tumor;Tumor Tissue;U-Series Cooperative Agreements;Update;Urine;vaping;Work;X-Ray Computed Tomography

PROJECT_TITLE: The Boston Lung Cancer Survival Cohort


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lung Cancer

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Collective invasion is a major mode of metastasis observed in patients across most solid tumor types. We developed a new imaging-based technique to obtain molecular and epigenetic data of specialized cell types within the lung cancer collective invasion pack. We will use this information to probe the mechanistic underpinnings of Myo10 function within the collective pack.

PI_NAMEs: MARCUS, ADAM I. (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Address;angiogenesis;Automobile Driving;Back;cancer cell;Cancer Etiology;Cancer Patient;Cell Count;Cell Line;cell population study;cell type;Cells;Cellular biology;Cessation of life;Communication;Data;Disease;Disseminated Malignant Neoplasm;Epigenetic Process;epigenomics;ex vivo imaging;Extracellular Matrix;fibrillogenesis;Fibronectins;Filopodia;Genes;Genetic Transcription;genome-wide;genomic platform;genomic profiles;Genomics;Heterogeneity;Histologic;Image;image guided;in vivo;Individual;insight;Invaded;Lung;lung cancer cell;lung tumorigenesis;Malignant neoplasm of lung;Mechanics;Mediating;Methylation;mimicry;Modeling;Molecular;Molecular Analysis;mouse model;Movement;Neoplasm Metastasis;notch protein;overexpression;Pathway interactions;Patients;Pattern;Phenotype;Population;Prevalence;programs;promoter;Publishing;Research;Resolution;Resources;Shapes;Signal Transduction;Slice;Solid Neoplasm;spatiotemporal;Stream;Structure of parenchyma of lung;Supporting Cell;Techniques;Testing;therapeutic target;three dimensional cell culture;tool;Transcriptional Activation;transcriptome;tumor;tumor progression;Western Blotting;Width;Xenograft Model

PROJECT_TITLE: Deconstructing the collective invasion pack to define Myo10 function

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric;Prevention

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The proposed project is relevant to public health because early identification of behavioral and academic deficits for school readiness is crucial for timely intervention and prevention of more severe outcomes, such as conduct problems, problems with peer interactions, and school dropout. The expected results will have identified neural processes and cognitive control processes that explain how parenting practices influence children's school readiness. Thus, the proposed research is relevant to the part of the NICHD mission that all children have the chance to achieve their full potential for healthy and productive lives.

PI_NAMEs: PETERSEN, ISAAC T (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Academic skills;Acceleration;Adult;Age;Age Years;Aggressive behavior;Attentional deficit;Behavior;Behavior Therapy;Behavioral;Brain;Child;Child Rearing;Cognition;cognitive control;cognitive process;Competence;conduct problem;Data;design;Detection;Development;Disease;early childhood;Early Diagnosis;Early identification;Early Intervention;Electroencephalography;Environment;Event-Related Potentials;externalizing behavior;frontal lobe;Goals;innovation;Intervention;kindergarten;Laboratories;Lead;longitudinal analysis;mathematical difficulties;Mathematics;Measures;Mediating;Methods;Mission;National Institute of Child Health and Human Development;neural;neurodevelopment;neuroregulation;novel strategies;Nursery Schools;Outcome;parental influence;Parents;Pathway interactions;peer;performance based measurement;Prefrontal Cortex;prevent;Prevention;Prevention strategy;Problem behavior;Process;Productivity;psychologic;psychosocial;Public Health;Readiness;Reading;reading difficulties;Reporting;Research;response;Risk;scaffold;School Drop-Outs;Schools;Science;skills;Structure;Student Dropouts;success;sustained attention;System;teacher;Testing;Time;Translating

PROJECT_TITLE: Cognitive Control in the Development of School Readiness in Early Childhood

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Tuberculosis is a major global health burden, killing more than 1.5 million people every year, despite the availability of therapy. A central clinical and microbiologic feature of the disease is the ability of Mycobacterium tuberculosis (Mtb) to resist complete elimination, both by the host immune system and by chemotherapeutic agents. This project will investigate the host and bacterial determinants that mediate persistence of Mtb within its human host.

PI_NAMEs: EHRT, SABINE  (contact);GLICKMAN, MICHAEL S

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Aftercare;Antibiotic Therapy;Antibiotics;Antimycobacterial Agents;Antitubercular Antibiotics;Bacillus;Bacteria;Biological;Biological Markers;Blood specimen;Body Fluids;Cells;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;chronic infection;Clinical;Clinical Data;clinical research site;cohort;Country;data management;design;Disease;Drug Kinetics;empowerment;Enrollment;experience;Failure;Family;Genes;Genetic;genetic variant;global health;Goals;Growth;gut microbiome;Haiti;high dimensionality;high risk;Human;Human Genetics;Immune;Immune system;Immunologics;immunopathology;Immunophenotyping;Individual Differences;Infection;Infection Control;insight;Integration Host Factors;Knowledge;Length;Machine Learning;Maintenance;Measures;Mediating;microbiome;microbiome composition;microbiome research;Modeling;mouse model;Mouse Strains;Mus;Mycobacterium tuberculosis;next generation sequencing;Organ;pathogen;Patients;Persons;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Plasma;Population;Predisposition;pressure;Process;recruit;Recurrence;Relapse;relapse prevention;relapse risk;Research Personnel;Resolution;Resources;response;Role;Sampling;Sampling Studies;Siblings;Sterilization;success;synergism;Testing;Tissues;transcriptomics;Treatment outcome;treatment response;Tuberculosis;tuberculosis chemotherapy;tuberculosis drugs;tuberculosis treatment;TYK2;Work

PROJECT_TITLE: Determinants of TB control, relapse and reinfection


PI_NAMEs: EHRT, SABINE  (contact)

PROJECT_TERMS: Agreement;analytical tool;bean;Clinical Data;Clinical Management;Collaborations;Collection;Communication;Computational Biology;Data;Data Analyses;Data Coordinating Center;data exchange;data management;data sharing;Data Storage and Retrieval;Databases;Funding;Goals;Infection;Infrastructure;Institution;meetings;member;Monitor;Names;National Institute of Allergy and Infectious Disease;Office of Administrative Management;Policies;Procedures;programs;Progress Reports;Recording of previous events;Relapse;Reporting;Research;Resolution;Resources;sample collection;Sampling;Scientist;Shipping;success;synergism;Technology;Testing;Time;United States National Institutes of Health;Work

PROJECT_TITLE: Admin Core


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: Pneumonia has long been the leading cause of death from infection in the United States, but the evidence underlying standard clinical care remains relatively sparse. The COVID-19 pandemic resulted in practice changes that challenged existing standards. This project will examine changes in antibiotic and steroid use for pneumonia that emerge from the pandemic, and explore more tailored approaches that better match treatment to the complexity of individual patients. Our research team studied VA provider decision-making for pneumonia prior to the pandemic and compared the effectiveness of various treatments. This previous work allows us to examine changes in beliefs and approaches. Our proposed study will use rigorous re- search methods that combine interviews with healthcare data to examine how treatment for Veterans with pneumonia is evolving, and inform how it should evolve and be implemented. Our research will inform new treatment standards for patients with pneumonia that take into account individual patient differences.

PI_NAMEs: JONES, BARBARA ELLEN (contact)

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Adopted;Adoption;Algorithms;Antibiotics;behavior change;Belief;Caring;causal model;Cause of Death;Cessation of life;Clinical;Clinical assessments;clinical care;Clinical Practice Guideline;cognitive process;Communicable Diseases;community acquired pneumonia;compare effectiveness;Complex;Coupled;COVID-19;COVID-19 pandemic;Data;Data Analyses;Decision Making;Decision Trees;design;Diagnosis;Diagnostics Research;disease model;Etiology;evidence base;experience;Face;Failure;Future;future pandemic;Healthcare;Heterogeneity;Hospitalization;Immune response;implementation efforts;implementation strategy;individual patient;Infection;Informatics;innovation;Intervention;Interview;Knowledge;Left;Machine Learning;Medical;Methodology;Methods;Modeling;mortality;Natural experiment;Natural Language Processing;novel strategies;novel therapeutic intervention;Observational Study;pandemic disease;pathogen;pathogenic virus;Patient-Focused Outcomes;Patients;personalized approach;Pneumonia;Pragmatic clinical trial;pre-pandemic;programs;Provider;provider adoption;randomized trial;Recommendation;Research;Research Methodology;Research Personnel;Resistance;Respiratory Tract Infections;response;secondary infection;Sepsis;Site;standard care;Steroids;Stream;Supportive care;Surveys;System;Testing;Therapeutic Research;treatment and outcome;treatment optimization;United States;Variant;Veterans;Viral;viral pandemic;Work

PROJECT_TITLE: Leveraging pandemic practice changes to optimize evidence-based pneumonia care

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

PI_NAMEs: FITZGERALD, DANIEL W (contact)

PROJECT_TERMS: Aftercare;Age;Ambulatory Care Facilities;Antitubercular Agents;Back;Biological Assay;Blood;Caribbean region;Case Report Form;Center for Translational Science Activities;Chemistry;Chest;chronic infection;Clinical;Clinical Data;Clinical Research;Clinical Sciences;cohort;Collaborations;Collection;Communities;Computer software;Country;Cross-Sectional Studies;Data;Data Coordinating Center;Data Set;Dedications;Development;Diagnosis;Disease;DNA;Drug Kinetics;drug sensitivity;Drug toxicity;drug-sensitive;Enrollment;Equipment;experience;Family;Feces;follow-up;Genetic;Genotype;Genus Mycobacterium;Goals;Government;Haiti;Haitian;Hematology;high risk;HIV Seronegativity;HIV/TB;Immunologics;Immunophenotyping;Incidence;Individual;Infection;Institution;Institutional Review Boards;Internet;Laboratories;Laboratory Research;Liquid substance;Longitudinal cohort study;Lung;medical schools;Microbiology;microbiome analysis;microbiome therapeutics;Molecular;monocyte;mortality;Multi-Drug Resistance;mycobacterial;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;New York;Nongovernmental Organizations;Nonprofit Organizations;Participant;patient population;Patients;peripheral blood;Persons;Plasma;Procedures;programs;Quality Control;recruit;Recurrence;Regimen;Regulation;Relapse;Research;Research Personnel;Research Support;retention rate;Retreatment;Retrieval;Risk;RNA;Sampling;Sampling Studies;screening program;Serology;Serum;Services;sex;Shipping;Siblings;Solid;Sputum;System;Testing;Time;Training;treatment center;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;United States National Institutes of Health;Urine;Visit;volunteer;welfare;Whole Blood

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences;Sleep Research

ORG_CITY: WALTHAM

ORG_DEPT: BIOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative Amblyopia, or reduced vision due to the effects of early abnormal visual experience, affects approximately 3% of the human population. Designing effective treatments requires an understanding of the plasticity mechanisms that underlie this process, and how they are gated by behavioral states such as sleeping and waking. This proposal will test an influential theory about how sleep regulates experience-dependent plasticity, and will illuminate the processes that allow visual function to remain stable or improve in the face of sensory and learning-induced perturbations.

PI_NAMEs: TURRIGIANO, GINA G (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Affect;Amblyopia;Animals;area striata;Arousal;basal forebrain;Behavior;Behavioral;Binding;Brain;cholinergic;design;effective therapy;Excitatory Synapse;experience;experimental study;Eye;Funding;Gryllidae;hippocampal pyramidal neuron;Homeostasis;Human;Image;improved;in vivo;Influentials;insight;learned behavior;Learning;Long-Evans Rats;monocular;Neocortex;neocortical;neuroregulation;non rapid eye movement;optogenetics;Pattern;permissiveness;Physiology;Population;Process;Resolution;response;restoration;Rodent;Role;scale up;segregation;Sensory;Sleep;Source;Synapses;Synaptic plasticity;Testing;theories;V1 neuron;Vision;Visual;Visual Cortex;visual deprivation;Visual impairment;Work

PROJECT_TITLE: Gating of Firing Rate Homeostasis by Sleep and Wake States During Experience-Dependent Plasticity

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Fetal Alcohol Spectrum Disorders (FASD);Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Alcohol-exposed pregnancy (AEP) can cause lifetime intellectual and physical disabilities, including Fetal Alcohol Spectrum Disorders, but AEP can be prevented with behavioral interventions. This project will be the first to systematically optimize a previously tested digital behavioral intervention, CARRII, for Native women at risk for AEP. The project will generate a new digital AEP intervention for Native women that could sustainably reduce AEPs in this high-risk subpopulation at acceptable costs.

PI_NAMEs: HANSON, JESSICA D;INGERSOLL, KAREN S (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Advertising;Alcohol consumption;alcohol risk;Alcohols;automated text message;Automation;Back;Behavior Therapy;binge drinking;birth control;Brain;Child;Code;Communities;Contraceptive methods;cost;Counseling;Data;design;Devices;digital;digital intervention;disability;drinking;Dropout;Education;Equilibrium;evidence base;experimental study;Feasibility Studies;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Focus Groups;follow-up;Frequencies;General Population;Goals;Great Plains;health literacy;Heavy Drinking;high risk;high risk drinking;High Risk Woman;Human;Inequity;Intellectual functioning disability;interest;Intervention;Interview;life time cost;Measures;Mediation;Methods;motivational enhancement therapy;multiphase optimization strategy;Native Americans;Navajo;Nervous System Trauma;novel;Organ;outreach;Participant;Phase;physically handicapped;pilot test;pilot trial;Pregnancy;Pregnancy Tests;pregnant;Pregnant Women;prevent;prototype;Randomized;recruit;Risk;Risk Behaviors;Risk Reduction;Safe Sex;Sampling;Seminal;sexually active;skills;Subgroup;Surveys;Testing;Text Messaging;theories;Time;timeline;Tissues;Training;Treatment Efficacy;tribal community;Tribes;unintended pregnancy;Woman;Work;working group

PROJECT_TITLE: Optimizing a Digital AEP Risk Intervention with Native Women and Communities

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Eczema / Atopic Dermatitis;Genetics;Infectious Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Individuals suffering from atopic dermatitis are at increased risk of developing severe infections, but the reason(s) are not well understood. Our goal is to determine whether the local tissue environment impairs the persistence or function of immune cells within the skin of patients with allergic diseases. Based on these studies, novel therapies may be developed to improve protection from infection in these patients.

PI_NAMEs: BROMLEY, SHANNON K (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Adult;Allergic Disease;Anti-Bacterial Agents;antigen challenge;ATAC-seq;Atopic Dermatitis;Bacterial Genes;Biological Markers;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Chromatin;Cutaneous;cytokine;cytotoxic;Data;Disease;Eczema;Eczema Herpeticum;Eczema Vaccinatum;effector T cell;Environment;Exposure to;Extrinsic asthma;Focal Infection;Gene Expression;Genes;Goals;Herpes Simplex Infections;Human;immune function;Immune response;Impairment;improved;in vivo;Individual;Infection;Infectious Skin Diseases;Inflammation;Inflammatory;inhibitor;Integrins;Interleukin-13;Interleukin-4;Intestines;Invaded;Leukocytes;Lung;Maintenance;Malignant Neoplasms;Measures;Mediating;Memory;Morbidity - disease rate;mortality;mouse model;Mus;neutralizing antibody;novel therapeutics;Nuclear Translocation;pathogen;Patients;Peripheral;Phenotype;Phosphorylation;Predisposition;prevent;Proliferating;protein expression;Psoriasis;receptor;recruit;Recurrence;response;Risk;Role;Sampling;Signal Transduction;Simplexvirus;Skin;Testing;Tissues;transcription factor;Transforming Growth Factor beta;treatment effect;tumor;Vaccinia virus;Viral;Virus Diseases;Virus Replication;Wild Type Mouse

PROJECT_TITLE: Effect of Th2-type microenvironment on CD8 TRM-mediated protection from infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-B(57)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Microbiome;Orphan Drug;Precision Medicine;Rare Diseases;Tuberculosis

PI_NAMEs: DARTOIS, VERONIQUE  (contact)

PROJECT_TERMS: adaptive immunity;Aftercare;Algorithms;Analytical Chemistry;Animals;Bacteria;Binding Proteins;Biological;biosafety level 3 facility;Blood;Bronchoalveolar Lavage;Cell Physiology;Cells;chemotherapy;chronic infection;Clinical;clinical practice;Code;cohort;complex data;congenital immunodeficiency;cytokine;Data;Data Analyses;Data Set;data visualization;Detection;dimension reduction;dimensional analysis;Dimensions;Disease;Disease Outcome;Disease Progression;Dose;Doxycycline;Drug Exposure;Drug Kinetics;Drug Monitoring;dysbiosis;Ethambutol;Exhibits;Flow Cytometry;Genetic;Genetic study;Genotype;Grant;Haitian;Health;high dimensionality;high risk;Human;Immune;Immune response;immunodeficiency;Immunologic Markers;Immunologics;immunopathology;Immunophenotyping;Individual;infected vector rodent;Infection;Inflammatory;inter-individual variation;isoniazid;Laboratory mice;Lesion;liquid chromatography mass spectrometry;Liquid substance;Lung;Lymphocyte Immunophenotypings;Lymphocyte Subset;mathematical algorithm;Measures;Memory;Meridians;Messenger RNA;Metabolism;microbiome;microbiome research;Modeling;Monitor;mouse model;Mouse Strains;Mus;mutant;Mutation;Mycobacterium tuberculosis;Myeloid Cells;Natural Immunity;novel;Outcome;patient population;Patients;Pattern;PET/CT scan;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;Pharmacogenetics;Pharmacogenomics;pharmacologic;Pharmacology;Phase;Phenotype;Plasma;Plasma Proteins;Play;Population;Predisposition;preservation;Procedures;programs;Pyrazinamide;recruit;Recurrence;Relapse;relapse risk;Resource Sharing;response;Rifampin;RNA;Role;Saliva;Sampling;Site;Sputum;Stains;Standardization;Suspensions;Testing;Therapeutic;Time;Tissues;trait;transcriptomics;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Urine;Variant;X-Ray Computed Tomography

PROJECT_TITLE: Pharmacology & ImmunoPathology (PIP) Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Regenerative Medicine

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Narrative Articular cartilage enables efficient and pain-free transfer of load across joints with the activities of daily living, but is often compromised by traumatic injury and disease, and has a poor endogenous healing capacity. To address this, we develop a novel therapeutic approach that leverages the interaction between regenerative bone marrow derived mesenchymal stromal cells and a small number of chondrocytes delivered using customized micro-scale hydrogels. We further develop a clinically relevant delivery system and evaluate the potential of this new therapy to foster the formation of functional tissue in a pre-clinical large animal model of cartilage repair.

PI_NAMEs: BURDICK, JASON A;MAUCK, ROBERT L (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Acute;Address;Adhesions;Animal Model;Animals;articular cartilage;Autologous;Biochemical;Biomedical Engineering;Biophysics;Bone Marrow;Cartilage;cartilage development;Cartilage injury;Cartilage Matrix;cartilage regeneration;cartilage repair;Cell Communication;Cell Density;Cell Differentiation process;Cells;Chondrocytes;Chondrogenesis;Chronic;Clinical;clinical translation;clinically relevant;Coculture Techniques;Collaborations;combinatorial;Communication;crosslink;Cues;Custom;Defect;design;Development;Disease;Dose;efficacy evaluation;Encapsulated;Engineering;Environment;Extracellular Matrix;extracellular vesicles;Family suidae;Formulation;Fostering;Funding;Goals;Growth Factor;Harvest;healing;Histology;Hyaluronic Acid;Hydrogels;Hypertrophy;Image;imaging biomarker;Imaging Techniques;improved;In Vitro;in vivo;Inflammation Mediators;Injectable;Injections;innovation;intercellular communication;interdisciplinary approach;Joints;Ligands;Manuscripts;mechanical load;Mechanics;Mediating;Mentors;Mesenchymal Differentiation;mesenchymal stromal cell;minimally invasive;Modeling;Molecular;Monitor;N-Cadherin;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Orthopedic Surgery;Osteogenesis;Outcome;Pain Free;paracrine;Paracrine Communication;Patients;Peptides;Phenotype;pre-clinical;Production;Progress Reports;Property;Proteomics;regenerative;repaired;Research;Resources;scale up;screening;Signal Transduction;Sports Medicine;Surface;Surgeon;System;Techniques;Time;tissue regeneration;Tissues;trafficking;transmission process;Traumatic injury;Vesicle;Visualization;Weight-Bearing state;Work

PROJECT_TITLE: Engineered Developmental Microenvironments: Cartilage Formation and Maturation

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_DEPT: PHYSICS

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE Microscopic tumor deposits missed by surgery cannot be resolved using current clinical imaging technologies and often harbor cell populations resistant to chemotherapy, representing a prominent source of cancer recurrence and mortality. The goal of this proposal is to develop a new paradigm for cancer therapy using multiplexed molecular imaging to detect residual cancer cells and to guide personalized photomedicine for targeting heterogeneous and chemoresistant micrometastases.

PI_NAMEs: SPRING, BRYAN QUILTY (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Acute;Address;antagonist;Antibodies;arm;Binding;bioimaging;Biological Markers;Biological Models;Calibration;cancer cell;Cancer cell line;Cancer Patient;cancer recurrence;cancer stem cell;cancer therapy;Carcinomatosis;Cell Death Induction;Cell membrane;Cell surface;Cell Survival;Cells;Chemoresistance;Chemosensitization;chemotherapy;Clinical;clinical imaging;Complement;Complex;Culture Techniques;Deposition;Development;Disease;Disease Resistance;Drug Kinetics;Drug resistance;Epidermal Growth Factor Receptor;Epithelial ovarian cancer;Evolution;Feedback;Fluorescence;Genetically Engineered Mouse;Genotype;Goals;Greater sac of peritoneum;Heterogeneity;Human;Image;Image Enhancement;image guided;image guided therapy;imaging agent;imaging biomarker;imaging informatics;imaging modality;imaging platform;Imaging technology;Immunocompetent;Immunoconjugates;improved;In Vitro;in vivo;in vivo imaging;in vivo Model;in vivo optical imaging;Intestines;Lead;Left;Malignant Neoplasms;Measures;Membrane;Methods;microendoscope;microendoscopy;Micrometastasis;Microscope;Microscopic;microscopic imaging;miniaturize;minimally invasive;Modality;Modeling;molecular dynamics;molecular imaging;Molecular Target;Monitor;mortality;mouse model;Mus;neoplastic cell;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;Optical Biopsy;optical imaging;Organ;Ovarian;overexpression;patient derived xenograft model;Patients;Pelvic cavity structure;Peritoneal;personalized cancer therapy;personalized medicine;Pharmaceutical Preparations;Phenotype;photoimmunotherapy;Phototoxicity;Polymerase Chain Reaction;Population;Preservation Technique;Proteolysis;Protocols documentation;receptor;Receptor Protein-Tyrosine Kinases;Recurrence;Recurrent disease;Regimen;Residual Cancers;Residual Neoplasm;Residual state;Resistance;Resistance development;Resolution;response;Reverse Transcription;Salvage Therapy;Series;Site;Source;Specificity;standard care;targeted treatment;Testing;Therapeutic Agents;Therapeutic Index;therapy resistant;three dimensional cell culture;three-dimensional modeling;Time;tomography;Translating;treatment optimization;treatment response;tumor;Tumor Burden;tumor heterogeneity;uptake;Visualization;Work;Xenograft procedure

PROJECT_TITLE: Multiplexed and dynamically targeted photoimmunotherapy of heterogeneous, chemoresistant micrometastases guided by online in vivo optical imaging of cell-surface biomarkers

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Lung;Microbiome;Orphan Drug;Precision Medicine;Rare Diseases;Tuberculosis

PROJECT_TERMS: Aftercare;Antibiotics;antimicrobial;Antimycobacterial Agents;Award;Biological;Biological Markers;candidate identification;Chemicals;Clinical;Clinical Trials;cofactor;cohort;Collaborations;Combination Drug Therapy;Computer Models;Coupled;Cross-Sectional Studies;Data;Disease;Disease Outcome;Drug resistance;drug-sensitive;Evolution;fecal microbiome;Feces;First Independent Research Support and Transition Awards;gut microbiome;high risk;Human;human subject;Immune;Immune system;immunoregulation;Individual Differences;Infection;inflammatory marker;insight;Laboratories;Logic;longitudinal human study;machine learning model;Mediator;Metagenomics;microbiome;microbiome alteration;microbiome composition;microbiome research;microbiota;Modeling;mouse model;mycobacterial;Mycobacterium tuberculosis;neural;novel;pathogen;Patients;peripheral blood;Persons;Population;Prediction of Response to Therapy;Predisposition;preservation;Probability;Production;Recurrence;Relapse;relapse risk;Resolution;Risk;Risk Factors;Sampling;Series;Sputum;Statistical Models;Sterilization;Structure;success;Taxon;Taxonomy;Techniques;therapy duration;transcriptomics;treatment duration;treatment response;Tuberculosis;tuberculosis treatment;Volatile Fatty Acids

PROJECT_TITLE: Microbiome in TB treatment response and disease resolution


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Machine Learning and Artificial Intelligence;Palliative Care;Patient Safety;Precision Medicine;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: AMHERST

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Patients with chronic obstructive pulmonary disease who are discharged from the hospital have high rates of early readmission; these readmissions are a significant burden to the health care system. The proposed research will combine social information with rich clinical data to develop a real-time readmission risk prediction algorithm that will be integrated into a patient-centric intervention and tested in real-world clinical practice settings. The information learned from this project will assist in providing individualized treatment at the transition from hospital to home and focused on reducing healthcare utilization and ultimately improving quality of care.

PI_NAMEs: JACOBS, DAVID  (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Active Learning;Address;administrative database;Admission activity;Affect;Automobile Driving;Award;biomedical informatics;care coordination;career development;Caregivers;Caring;Chronic Obstructive Pulmonary Disease;Clinical;clinical care;Clinical Data;Clinical Pharmacists;clinical practice;clinical predictive model;Clinical Research;Clinical Trials Design;Complex;cost;cost effectiveness;Data;Development;Development Plans;Diagnosis;Discipline of Nursing;Education;Electronic Health Record;Epidemiology;Event;experience;Face;feasibility testing;health care service utilization;Health Expenditures;Health Services;Health Services Research;Healthcare Systems;high dimensionality;high risk;Home;hospital readmission;Hospitalization;Hospitals;implementation science;improved;improved outcome;Individual;individualized medicine;Informatics;informatics tool;innovation;Intervention;Interview;K-Series Research Career Programs;Knowledge;Learning;Length of Stay;Link;Machine Learning;Managed Care;Mentors;Mentorship;Methodology;Modeling;Monitor;multidisciplinary;Natural Language Processing;Nature;Outcome;Patient Care;Patient Discharge;Patient Readmission;patient safety;Patients;Performance;personalized care;personalized medicine;Pharmaceutical Preparations;Pharmacy facility;Population;Positioning Attribute;practice setting;Pragmatic clinical trial;prediction algorithm;predictive modeling;predictive tools;Primary Care;Program Sustainability;Provider;Public Health;Quality of Care;readmission rates;readmission risk;Recovery;Research;Research Personnel;Resources;Risk;Risk Factors;risk prediction;risk prediction model;risk stratification;Sampling;skills;social;Social Characteristics;social disparities;social factors;Social support;Structure;success;Techniques;Testing;therapy design;Time;tool;Training;United States;Universities;Work

PROJECT_TITLE: Integrative Informatics Approach to Predict Readmissions and Improve Outcomes in COPD

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The major unmet need for colorectal cancer (CRC) patients is low efficacy and safety of the current clinically used drug therapies. We have identified oncogenic CHD1L, a relatively new molecular target that drives CRC tumor malignancy and poor prognosis for CRC patients. This project will validate the first-in-class inhibitors of CHD1L and evaluate them for therapeutic potential using biochemical, cell based, and in vivo models CRC.

PI_NAMEs: LABARBERA, DANIEL V. (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: 3-Dimensional;analog;anti-tumor agent;ATP phosphohydrolase;Biochemical;Biological Assay;Breast;cancer diagnosis;Cancer Model;cancer type;Cell model;Cells;cellular transduction;CHD1 gene;Chemicals;Clinical;clinical practice;cohort;colon cancer patients;Colorectal Cancer;colorectal cancer treatment;Complex;Coupled;cytotoxicity;Data;Death Rate;design;Development;Diversity Library;DNA Binding;Dose;driving force;Drug Design;drug discovery;Drug Kinetics;Drug resistance;Drug Targeting;Drug usage;effective therapy;efficacy evaluation;Epithelium;gastrointestinal;Gene Expression;Genes;Glioma;Goals;HCT116 Cells;Hepatocyte;high throughput screening;high-throughput drug screening;Human;In Vitro;in vivo;in vivo imaging system;in vivo Model;inhibitor;Invaded;knock-down;Knowledge;Lead;Ligands;Link;lipophilicity;Literature;Malignant - descriptor;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant Neoplasms;Maximum Tolerated Dose;Measures;Mesenchymal;metastatic colorectal;meter;Methodology;Microsomes;Modeling;Molecular Probes;Molecular Target;neoplastic cell;novel;novel therapeutics;Nude Mice;Oncogenes;Oncogenic;Organoids;Outcome;overexpression;Pathology;patient derived xenograft model;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology;Pharmacology Study;pharmacophore;Pharmacotherapy;Phase;Plasma;Prognosis;Property;Recombinants;recruit;Reporter;Reporting;Research;response;Role;Safety;Sampling;small molecule;small molecule inhibitor;Solid;Solid Neoplasm;Solubility;standard of care;stemness;Survival Rate;SW620;targeted treatment;TCF Transcription Factor;Testing;Therapeutic;therapeutic development;therapeutically effective;Tissue Banks;tool;Toxic effect;transcription factor;Transfection;tumor;tumor growth;tumor progression;Validation;virtual;Work;Xenograft procedure

PROJECT_TITLE: The Development of First-in-Class Inhibitors of Oncogenic CHD1L for the Treatment of Colorectal Cancer.

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE Erectile dysfunction (ED) imposes profoundly negative impacts on well-being of the affected males, particularly those with neurovascular defects (e.g., diabetes, hypertension, prostate cancer, etc.), but currently available treatments moderately manage the symptom at best. Encouragingly, we have discovered that a naturally- occurring biological agent, specifically stromal cell-derived factor-1 (SDF-1), possesses unique ability to potentially reverse the underlying cause of the disease. We thus propose here to develop novel SDF-1-based mRNA therapy for safe, sustainable and unprecedentedly curative treatment of ED.

PI_NAMEs: HANNAN, JOHANNA LUCY;SUK, JUNG SOO  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Affect;Age;Architecture;Biological Products;Cell Nucleus;Cells;Characteristics;Chemicals;Chronic;Cialis;Clinical;clinical development;Clinical Research;clinically relevant;curative treatments;Custom;Data;Defect;delivery vehicle;design;Diabetes Mellitus;Disease;Dose;Drug Interactions;Economics;Endocrine system;Engineering;Environment;Erectile dysfunction;Excision;Exhibits;Fibrosis;Formulation;Frequencies;Functional disorder;Ganglia;Genes;Goals;Growth Factor;Half-Life;Health;Histology;Human;Hypertension;improved;In Vitro;in vivo;Individual;inhibitor;Injections;injured;Injury;Insertional Mutagenesis;interest;Kinetics;Lead;lead candidate;male;Malignant neoplasm of prostate;Measures;men;Messenger RNA;Modality;Modeling;mRNA delivery;mRNA Expression;multidisciplinary;Muscle;nanoparticle;nanoparticle delivery;nanopolymer;Natural regeneration;Nerve;Nervous System;Neurons;neurovascular;neurovascular injury;novel;nucleic acid delivery;Oral;Pathology;Pathway interactions;Patients;Pelvis;penis;Personal Satisfaction;Pharmaceutical Preparations;phosphoric diester hydrolase;Physiological;plasmid DNA;Polymers;Population;pre-clinical;preclinical study;prevent;prostate cancer model;Prostate Cancer therapy;Prostatectomy;Proteins;Quality of life;Radical Prostatectomy;Rattus;Recombinants;Regimen;repaired;Reporter;response;Risk;Rodent;Safety;safety study;side effect;Smooth Muscle;standard of care;stem cells;Stromal Cell-Derived Factor 1;Study models;symptom management;symptomatic improvement;System;Therapeutic;Time;Tissues;Transfection;Treatment Efficacy;Up-Regulation;Urology;Variant;Vascular System;Viagra

PROJECT_TITLE: Localized SDF-1 mRNA nanoparticle delivery for treating erectile dysfunction.

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ORG_CITY: MILWAUKEE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Autoimmune diabetes is characterized by an inflammatory reaction in and around pancreatic islets, followed by selective destruction of insulin producing b-cells. In this proposal, we explore the role of virus infection as an initiation event leading to the destruction of b-cells during the development of this disease. The focus of the current application is to identify pathways used by b-cells to defend themselves against damage associated with virus infection, and we hope that information gained in these studies will lead to a better understanding of disease pathogenesis and identify novel targets for the design of therapeutic strategies to prevent or delay disease onset.

PI_NAMEs: CORBETT, JOHN A (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Autoimmune Diabetes;Autoimmune Diseases;autoimmune pathogenesis;B-Cell Activation;B-Lymphocytes;Beta Cell;Biochemical;cell injury;Cell Physiology;Cell Respiration;Cell Survival;cytokine;defense response;design;Development;Diabetes Mellitus;Disease;Double-Stranded RNA;Encephalomyocarditis virus;Enterovirus;Environmental Risk Factor;Event;extracellular;fitness;Free Radicals;Genetic Predisposition to Disease;Goals;Immunologics;Infection;Inflammatory;Inflammatory Response;Inositol Metabolism Pathway;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;Interferons;Islets of Langerhans;Location;Macrophage;Macrophage Activation;Mediating;Mediator;Mitochondria;Molecular;Monozygotic twins;Mouse Strains;Mus;Nitric Oxide;NOS2A gene;novel;novel therapeutic intervention;Onset of illness;pathogen;Pathogenesis;Pathway interactions;Predisposition;prevent;Production;programs;protective pathway;Reaction;Research;response;Role;sensor;Structure of beta Cell of islet;T-Lymphocyte;Techniques;Testing;Therapeutic;Transgenic Organisms;Viral;Virus Diseases;Virus Replication

PROJECT_TITLE: Mechanisms of Viral-Induced Beta Cell Damage

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Primary Immunodeficiencies;Rare Diseases;Tuberculosis

ORG_CITY: NEW YORK

PI_NAMEs: CASANOVA, JEAN-LAURENT  (contact)

PROJECT_TERMS: Accounting;Affect;African;Alleles;Alveolar Macrophages;autosome;Biochemical;Candidate Disease Gene;candidate identification;causal variant;Cell Line;cell type;Cells;Clinical;Code;Collaborations;Collection;Complementary DNA;Computer Analysis;Computing Methodologies;congenital immunodeficiency;Cytometry;Data;Databases;Development;Disease;Dryness;East Asian;Epidemiology;Ethnic Origin;Etiology;European;exome sequencing;experimental study;Exposure to;Family;Fibroblasts;Genes;Genetic;genetic epidemiology;Genetic Heterogeneity;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic study;genetic variant;genome sequencing;genome wide association study;genome-wide;Genotype;Haiti;Haitian;Health;high dimensionality;HLA-DRB1;Human;Human Genetics;Immune response;Immunity;immunodeficiency;Immunologics;immunopathology;Immunophenotyping;Impairment;In Vitro;Individual;induced pluripotent stem cell;Infection;Interferon Type II;Interleukin-12;interleukin-23;Investigation;kindred;Knowledge;Leukocytes;loss of function;Loss of Heterozygosity;Macrophage;Minority;Minority Groups;Modeling;Molecular;mouse model;Mycobacterium tuberculosis;next generation sequencing;novel;pathogen;Pathogenesis;Pathway interactions;Patient Recruitments;Patients;Penetrance;Pharmacology;Population;Population Heterogeneity;Predisposition;Preventive;Primary Infection;Probability;Production;Proteins;Proxy;reactivation from latency;recruit;Recurrence;Relapse;Reporting;response;Risk;Role;Sampling;secondary infection;Siblings;software development;stem;Techniques;Technology;Testing;Therapeutic;TNF gene;transcriptome sequencing;Tuberculosis;TYK2;Variant;whole genome

PROJECT_TITLE: Human Genetics of Tuberculosis


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Understanding determinants and consequences of the latent HIV reservoir are important for development of HIV cure approaches and optimizing long-term outcomes for children with HIV infection (CHIV). The proposed study will examine HIV reservoir clonal dynamics in early- and late-treated CHIV, specifically evaluating the role of CMV infection, and will evaluate how the reservoir contributes to long-term neurocognitive outcomes.

PI_NAMEs: JOHN-STEWART, GRACE C. (contact);WAMALWA, DALTON CHEKOKO

PROGRAM_OFFICER_NAME: LEE, SONIA S

PROJECT_TERMS: 8 year old;Acceleration;Acute;Address;Adherence;Adolescence;Adult;adverse outcome;Africa South of the Sahara;Age;antigen-specific T cells;Antigens;antiretroviral therapy;Biological Assay;CD4 Positive T Lymphocytes;Cells;Child;Child Health;Childhood;Chronic;Clonality;cohort;cost;Cytomegalovirus;Cytomegalovirus Infections;Data;Defective Viruses;design;Development;DNA;Drug resistance;epidemiology study;Epstein-Barr Virus Infections;Evaluation;executive function;follow-up;Freedom;Frequencies;HIV;HIV Infections;Human Herpesvirus 4;Immune;Immune response;improved;improved outcome;Income;infancy;Infant;Infection;Influenza;integration site;latent HIV reservoir;Life;Molecular Epidemiology;monocyte;Mothers;National Institute of Child Health and Human Development;Neurocognition;Neurocognitive;novel;Outcome;Pediatric cohort;pediatric human immunodeficiency virus;pediatric human immunodeficiency virus infection;Phenotype;Population;Productivity;Proliferating;Proviruses;Recurrence;Resistance;response;Role;Sampling;side effect;social stigma;T memory cell;T-Lymphocyte;Tetanus;Time;trafficking;United States National Institutes of Health;Viral;Viremia;Virus;Virus Activation;Work

PROJECT_TITLE: Pediatric HIV reservoir determinants and consequences

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Prevention;Social Determinants of Health;Substance Misuse

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Despite the great toll substance abuse takes on society, the pace of discovery of new and effective prevention and treatment strategies is only modest, and major delays exist in translating such knowledge into improved health of patients and populations. There is an urgent need to increase the number of health care professionals conducting clinically applicable research in the prevention and treatment of substance use disorders. The goal of this grant is to expand, and deepen the health equity focus and national impact of, a substance use disorder research training program targeting students in the fields of medicine, nursing, dentistry, social work and public health.

PI_NAMEs: GOUREVITCH, MARC N (contact)

PROGRAM_OFFICER_NAME: REICHEL, CARMELA MARIE

PROJECT_TERMS: addiction;Address;Attitude;career;Career Choice;Clinical;clinical application;Clinical Research;Collaborations;college;Country;Data;Dental;Dentistry;Dentists;design;Development;digital;Discipline;Discipline of Nursing;E-learning;editorial;Education;education research;Educational Curriculum;Educational Intervention;Educational Technology;Ensure;Evaluation;experience;faculty mentor;fascinate;Feedback;flexibility;follow-up;Fostering;Future;Goals;Grant;Growth Factor;Health;health equity;Health Professional;Home;Hospitals;improved;Individual;innovation;Institution;interest;International;Justice;Knowledge;Learning Module;Link;Medical;Medical Education;medical schools;Medicine;Mentors;National Institute of Drug Abuse;New York;Nurses;Online Systems;Outcome;Participant;Patients;Phase;Physicians;Population;population health;Prevention;Prevention strategy;primary outcome;Productivity;Professional Education;professional students;Program Development;programs;Psychiatry;Public Health;Public Health Students;Race;Ramp;recruit;Research;Research Personnel;Research Support;Research Training;Schools;Seasons;Silver;Social Work;Social Workers;Societies;Students;Substance abuse problem;substance use;Substance Use Disorder;substance use treatment;summer research;Teacher Professional Development;therapy design;Training;Training and Education;Training Programs;Translating;treatment strategy;Universities;Update;Visit;Work

PROJECT_TITLE: Substance Abuse Research Education and Training (SARET)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Clinical Research;Disability Research;Genetics;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Hereditary spastic paraplegia (HSP) is the most common cause of inherited spasticity and associated disability worldwide. Loss-of-function variants in the genes encoding the adaptor protein complex 4 (AP-4) lead to a prototypical form of HSP in children and can serve as a genetic model to understand the contributions of defective protein trafficking and autophagy to neurodegeneration. This project will develop a cross- organismal screening platform to identify and characterize novel modulators of protein trafficking for the treatment of HSP.

PI_NAMEs: EBRAHIMI-FAKHARI, DARIUS  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: 10 year old;Adaptor Protein Complex Subunits;Adaptor Signaling Protein;Address;Adult;Advisory Committees;Affect;age related;Autophagocytosis;Autophagosome;Axon;axonal degeneration;Behavior assessment;behavior test;Biological Assay;Biology;Boston;Brain;career;career development;Cells;Cellular biology;Child;Childhood;Complex;Corticospinal Tracts;CRISPR/Cas technology;Development;disability;Disease;disease model;Disease Progression;experimental study;Fibroblasts;Fluorescence;Foundations;Future;Genes;Genetic Engineering;Genetic Models;Goals;Hereditary Spastic Paraplegia;Human;human disease;human model;Image;Immunohistochemistry;Impairment;In Vitro;in vivo;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inherited;Integral Membrane Protein;knock-down;Label;Larva;Lead;loss of function;Loss of Heterozygosity;Lysosomes;LysoTracker;Measures;Mediating;medical schools;Mentors;Microscopy;Modeling;molecular phenotype;Morphology;Motor;motor deficit;Motor Neurons;Nerve Degeneration;Nervous System Disorder;Neurites;Neurodegenerative Disorders;neurodevelopment;Neurology;neuronal cell body;Neurons;novel;Pathway interactions;Patients;Pediatric Hospitals;Pediatric Neurology;Phenotype;Physicians;Positioning Attribute;Program Development;protein complex;protein phosphatase inhibitor-2;protein transport;Proteins;Research;restoration;Role;Scientist;screening;Simvastatin;skills;small molecule;spasticity;Spinal;Stains;Starvation;Survival Analysis;Testing;TFAP2A gene;trafficking;Training;trans-Golgi Network;Transcription Factor AP-1;translational neuroscience;translational pipeline;Translational Research;Variant;Vesicle;Western Blotting;Wheelchairs;Work;Zebrafish

PROJECT_TITLE: Development of a Translational Research Platform to Understand and treat Defective Protein Trafficking in Childhood-Onset Hereditary Spastic Paraplegia

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]