ORG_CITY: Durham

ORG_NAME: RHO FEDERAL SYSTEMS DIVISION, INC.

ORG_STATE: NC

PHR: PROJECT NARRATIVE This cooperative agreement funds a coordinating center that provides investigators across the United States with the tools, expertise, and support to conduct effective clinical research studies in allergic diseases and asthma. By ensuring consistency and quality of asthma and allergy research across multiple research sites, we can help provide new insights into management of these conditions and into biologic mechanisms of allergic disease development. These insights can lead to new treatment or prevention strategies that will improve the lives of people living with these conditions.

PI_NAMEs: DAVID, GLORIA ;VISNESS, CYNTHIA M (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Adverse event;Allergic Disease;Archives;Asthma;biobank;Biological;Biological Specimen Banks;Clinical;Clinical Data;Clinical Investigator;Clinical Protocols;Clinical Research;clinical research site;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Collaborations;Communication;Contractor;cost;Credentialing;dashboard;Data;data management;data sharing;Databases;Dedications;design;Development;Ensure;Equipment and supply inventories;Ethics;experience;Extrinsic asthma;flexibility;Funding;Funding Opportunities;Health Service Area;Human Resources;Hypersensitivity;improved;Infrastructure;innovation;insight;Internet;Leadership;Manuscripts;Methodology;Mission;Modernization;Monitor;National Institute of Allergy and Infectious Disease;novel therapeutic intervention;Observational Study;Participant;patient safety;Performance;Persons;pharmacovigilance;Preparation;prevent;Prevention strategy;Process;programs;protocol development;Protocols documentation;quality assurance;Quality Control;Reporting;repository;Research;Research Design;Research Personnel;research study;Research Support;Resource Sharing;Resources;rho;Safety;Safety Management;Sampling;Scientific Evaluation;Scientist;Secure;Services;Site;skills;Specimen;Standardization;Statistical Data Interpretation;Structure;System;Techniques;Technology;tool;Training;U-Series Cooperative Agreements;United States;web page;web portal;Work;Writing

PROJECT_TITLE: RhoFED AA-SCCC


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ORLANDO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: Project Narrative We propose constructing a two-organ microphysiological system composed of human cells for both sensory and motor segments of the reflex arc to study the effects of Alzheimer’s disease on the peripheral nervous system. We will establish clinically relevent functional models for AD by treating healthy systems with Aβ42 and tau oligomers in addition to motor and sensory systems composed of AD mutant iPSC MN-based NMJ systems to better understand the effects beyond the well studied systems in the brain.

PI_NAMEs: GUO, XIUFANG  (contact);MORGAN, DAVID

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: abeta oligomer;Afferent Neurons;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-42;Amyloid beta-Protein;animal data;Animal Model;Animals;Axon;Biological Aging;Biological Assay;Biological Markers;Biological Products;biological systems;biomarker discovery;biomarker identification;Blood Tests;Brain;Cells;Central Nervous System;Characteristics;Clinic;Clinical;clinical biomarkers;Clinical Markers;clinical predictors;Clinical Trials;clinically relevant;Cohort Studies;Collaborations;Companions;Complement;Data;Decision Making;Dementia;Deterioration;Development;Diagnostic;diagnostic criteria;Disease;Dose;Drug Screening;Evaluation;Exhibits;experience;experimental study;familial Alzheimer disease;Fiber;functional decline;Gait abnormality;Generations;Grant;high risk;Human;human induced pluripotent stem cells;human model;Impaired cognition;improved;in vitro Model;individualized medicine;induced pluripotent stem cell;Institutionalization;Investigation;Link;Longitudinal Studies;Measurement;microphysiology system;mild cognitive impairment;Modeling;Monitor;mortality;Motor;motor disorder;motor impairment;Motor Neurons;Muscle;Muscle Contraction;Muscle Fibers;mutant;Mutation;Nervous System Physiology;neuromuscular;Neuromuscular Junction;neuron component;neuronal cell body;novel;Organ;Outcome;Pathology;Patients;Peripheral Nervous System;Peripheral Nervous System Diseases;Pharmaceutical Preparations;Phenotype;Physiology;pre-clinical;Preclinical Testing;Publishing;Reflex action;response;Risk;Role;screening;Screening procedure;sensor;Sensory;sensory system;Serum;Skeletal Muscle;small molecule;Spinal;Stretching;success;System;Task Performances;tau aggregation;tau Proteins;Tauopathies;Testing;Therapeutic;tool;Toxic effect

PROJECT_TITLE: Investigating the role of Alzheimer's disease familial mutations in neuromuscular physiology

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Heart Disease;Muscular Dystrophy;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE This work involves a collaboration between the Chamberlain/Hauschka labs at the University of Washington and the Spencer/Kramerova labs at UCLA to develop a gene therapy for the disease limb girdle muscular dystrophy type 2A (LGMD2A). The disease involves progressively increasing muscle weakness, due to mutations in a gene that codes for calpain 3. This therapy will use a viral vector to deliver the gene throughout the body to all affected muscles.

PI_NAMEs: CHAMBERLAIN, JEFFREY S;SPENCER, MELISSA JAN (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: adeno-associated viral vector;Affect;Animal Model;Antibodies;Area;autosome;Binding Sites;Calpain;Cardiac;Cardiotoxicity;Clinical Trials;Code;Codon Nucleotides;Collaborations;Complementary DNA;design;Development;Diagnosis;differential expression;Disease;Dose;Duchenne muscular dystrophy;Dystrophin;Exercise Tolerance;experience;Fiber;Gene Delivery;Gene Expression;gene therapy;gene therapy clinical trial;Gene therapy trial;Gene Transduction Agent;Genes;Goals;Heart;Heart Block;Human;improved;in vitro testing;in vivo;International;Knockout Mice;Knowledge;laser capture microdissection;Limb structure;Limb-Girdle Muscular Dystrophies;Longitudinal Studies;member;micro-dystrophin;MicroRNAs;mini-dystrophin;mitochondrial dysfunction;Modification;mouse model;Mus;Muscle;Muscle Weakness;Muscular Atrophy;Muscular Dystrophies;Mutation;Myocardium;Neuromuscular Diseases;novel;Outcome;Outcome Measure;overexpression;Pathogenesis;Patients;Peptide Hydrolases;Phenotype;Physiological;pre-clinical;Property;Proteins;safety testing;Series;Skeletal Muscle;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Therapeutic Intervention;Time;Toxic effect;Transgenes;Treatment Efficacy;Universities;Untranslated Regions;Validation;Variant;vector;Viral Vector;Washington;Wasting Syndrome;Western Blotting;Wheelchairs;Work

PROJECT_TITLE: Optimizing and validation of gene therapy vectors to treat limb girdle muscular dystophy

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: TUCSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative This is a collaborative proposal to understand the molecular and cellular bases of memory changes in the context of aging and Alzheimer's disease. We have demonstrated that NPTX2, a marker of the information storage process, correlates with cognitive performance in humans during normative aging and in the context of Alzheimer's disease. Studies will examine the impact of NPTX2 reduction in human brain specimens and in neuronal circuits modeled in vitro using RNA and protein profiling, and the functional consequence of NPTX2 reduction on cognitive and behavior-linked circuit function using innovative rat models, and will provide fundamental new insights into memory, cognitive resilience, aging, and Alzheimer's disease.

PI_NAMEs: BARNES, CAROL A. (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Acceleration;Adult;Age;age effect;age related;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease related dementia;Amyloid;amyloid pathology;amyloid precursor protein processing;Animals;APP-PS1;asymptomatic Alzheimer's disease;Axon;base;Behavior;Behavior monitoring;behavior test;Biochemical;Biological Assay;Biology of Aging;Brain;candidate identification;Cell Nucleus;cell type;Cells;Chronology;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;Cognitive;cognitive change;cognitive performance;cognitive testing;cohort;Control Groups;Data;density;Deterioration;Disease;Disease Marker;Disease Pathway;Down-Regulation;Early Onset Alzheimer Disease;Electrophysiology (science);excitatory neuron;Excitatory Synapse;Exhibits;experimental study;Failure;familial Alzheimer disease;Female;Functional disorder;Genes;genetic manipulation;Genetic Models;Genetic Transcription;Goals;Health;healthspan;hippocampal pyramidal neuron;hippocampal subregions;Hippocampus;Human;human induced pluripotent stem cells;Impaired cognition;in vitro Model;Individual;individual variation;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Information Storage;inhibitory neuron;innovation;insight;Interneuron function;Interneurons;Interruption;Link;Longevity;loss of function;Maintenance;male;Mass Spectrum Analysis;Measures;Mediating;Memory;memory consolidation;Messenger RNA;MicroRNAs;Modeling;Molecular;Monitor;mRNA Expression;mutant;Mutation;Neurodegenerative Disorders;neuronal circuitry;neuronal excitability;neuronal pentraxin;Neurons;normal aging;Older Population;Outcome;outcome disparities;Parvalbumins;Pathogenesis;Pathologic;Pathology;Pathway Analysis;Pathway interactions;pharmacologic;Play;Positioning Attribute;Predisposition;preservation;Process;Property;protein profiling;Proteins;Proteomics;Rattus;Regulatory Pathway;resilience;response;Risk;Risk Factors;RNA;Rodent;Role;Sampling;Signal Pathway;single nucleus RNA-sequencing;Specimen;Structure of middle temporal gyrus;Synapses;tau mutation;tau Proteins;Testing;therapeutic target;tissue archive;Tissues;transcriptome sequencing;Transgenic Organisms;Virus;young adult

PROJECT_TITLE: NPTX2:  Preserving memory circuits in normative aging and Alzheimer's Disease


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: STANFORD

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Addressing unmet clinical needs will require Ph.D.-trained scientists who understand the molecular basis of human health and disease, the mechanisms of drug action, and the drug discovery process. To achieve this goal, the Stanford Molecular Pharmacology Training Program (MPTP) integrates rigorous basic science research with specialized coursework and hands-on experiences related to therapeutic development. Through its innovative curriculum, the MPTP will empower its graduates to translate fundamental discoveries into clinical advances.

PI_NAMEs: BOGYO, MATTHEW ;CHEN, JAMES K (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TITLE: Molecular Pharmacology Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Natural Products;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Emerging evidence suggests that co-use of marijuana and tobacco have greater deleterious effects on health than use of marijuana by itself. The proposed project will build on the limited research done in humans that examined the pharmacological interaction between marijuana and tobacco by manipulating both THC and nicotine dose administered to participants and characterizing THC and nicotine exposure and effects. The expected findings will help us understand the risk of co-use of marijuana and tobacco, a pattern of substance use done by a large majority of marijuana users.

PI_NAMEs: ST.HELEN, GIDEON  (contact)

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: Acute;Affect;age group;aged;Benefits and Risks;Blood flow;Carbon Monoxide;Cardiovascular system;Catecholamines;Cessation of life;Chemicals;Cigarette;cigarette smoking;Clinical Pharmacology;craving;Data;Disease;Dopamine;Dose;Drug Kinetics;experience;experimental study;Exposure to;Future;Health;Heart Rate;High Prevalence;Human;Illicit Drugs;Individual;Inhalation;Intake;Joints;Legal;male;Marijuana;marijuana use;marijuana use disorder;marijuana user;Mission;Modality;motor control;National Institute of Drug Abuse;Nicotine;nicotine exposure;Norepinephrine;Oral;Outcome;Paper;Participant;Pattern;Persons;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Physiological;Pilot Projects;Placebos;Plant Leaves;Plants;Plasma;Platelet aggregation;preservation;programs;psychologic;Public Health;Race;rate of change;Reaction Time;Recreation;Regulation;Reporting;Research;response;Rewards;Risk;Self Administration;Sensory;sex;Skin;Smoke;Smoking;Standardization;Study Subject;substance use;Testing;Tetrahydrocannabinol;THC exposure;Tobacco;Tobacco Dependence;Tobacco smoke;tobacco smokers;Tobacco use;tobacco user;vaping;Vaporizer;Visit;Weight

PROJECT_TITLE: Understanding the clinical pharmacology of marijuana-tobacco co-administration

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Latinos have the highest risk of acute lymphoblastic leukemia (ALL) in the United States, and inferior outcomes compared with non-Latino whites. In this study, we will leverage the unique evolutionary history of Native Americans to carry out a comprehensive study of the role of germline genetic variation in the increased risk of childhood ALL in Latinos. Our results will help to elucidate the causes of this significant ethnic disparity and to identify children most at risk of developing ALL.

PI_NAMEs: DE SMITH, ADAM  (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: Accounting;Acute Lymphocytic Leukemia;Admixture;admixture mapping;Americas;Awareness;California;case control;causal variant;Cesarean section;Cessation of life;Child;Childhood;Childhood Acute Lymphocytic Leukemia;Childhood Leukemia;Cytomegalovirus Infections;Data;disorder prevention;Environmental Exposure;Environmental Risk Factor;Epidemiology;epidemiology study;ethnic disparity;Ethnic Origin;Etiology;European;Exhibits;Face;Future;GATA3 gene;Gene Expression Profile;Gene Frequency;General Population;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic risk assessment;genetic risk factor;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;Genomic Segment;Germ Lines;Goals;Guatemala;Heritability;high risk;Human;Immune;Immune response;Immunological Models;improved;in utero;Incidence;Infection;Inferior;insight;Knowledge;Latino;Latino Population;Linkage Disequilibrium;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Meta-Analysis;Modeling;modifiable risk;Morbidity - disease rate;Native American Ancestry;Native Americans;Natural Selections;Nature;novel;Outcome;Pediatric Oncology Group;Play;polygenic risk score;Population;Prevention;Quantitative Trait Loci;Recording of previous events;Reporting;Risk;Risk Assessment;Risk Factors;risk mitigation;risk prediction;risk stratification;risk variant;Role;Saint Jude Children's Research Hospital;Sample Size;Survivors;Susceptibility Gene;Testing;Texas;transcriptome;transcriptomics;Trees;United States;Variant;Vulnerable Populations;Weight

PROJECT_TITLE: Understanding the Increased Risk of Childhood Acute Lymphoblastic Leukemia in Latinos

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: We have an on-going clinical trial, which is based on our research, evaluating the two pediatric doses of the anti- HIV drug efavirenz in patients with Alzheimer’s disease. Yet, we need to have a better understanding of how efavirenz acts in the brain when used at smaller doses and whether this drug could be further improved as a potential anti-Alzheimer’s disease medication. These gaps in our knowledge will be filled by the proposed research, which may ultimately lead to a new, disease-modifying treatment for Alzheimer’s disease.

PI_NAMEs: PIKULEVA, IRINA A (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: abeta deposition;Active Sites;Affect;Age;Age Months;Allosteric Site;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Anabolism;analog;Animals;Anti-HIV Agents;Astrocytes;behavior test;Binding;Biological;blood-brain barrier crossing;Body Weight;Brain;Central Nervous System;Childhood;Cholesterol;cholesterol biosynthesis;Cholesterol Homeostasis;Clinical Trials;comparative;Complex;Cytochrome P450;Data;Deposition;Development;Disease;Dose;drinking water;drug clearance;drug repurposing;efavirenz;Enzyme Activation;Enzyme Inhibition;Enzymes;Event;FDA approved;Genes;Genetic;Grant;Hepatic;HIV Seropositivity;Huntington Disease;Hydroxycholesterols;Hydroxylation;improved;In Situ;In Vitro;in vivo;Individual;insight;Investigation;Knowledge;Laboratories;Learning;Link;Maps;Marketing;Medical;Membrane;Memory;Microglia;Modeling;Mus;Neurons;next generation;Pathway interactions;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phosphoproteins;phosphoproteomics;Physiological;Probability;Process;Property;Proteins;Proteome;Research;Resolution;Roentgen Rays;Role;screening;Seizures;Signal Pathway;Sterols;Structure;Structure-Activity Relationship;Surface;Synapses;Synaptosomes;Testing;Therapeutic;therapeutic target;transcriptome sequencing;Up-Regulation;Western Blotting

PROJECT_TITLE: Cholesterol Metabolizing P450s: Structure and Function

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: PITTSBURGH

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE This research will test several novel hypotheses regarding the mechanisms of auditory cortex plasticity after cochlear damage and peripheral hearing loss. Because these mechanisms are involved in many disorders associated with sensory deficits, such as hearing loss, schizophrenia, tinnitus, hyperacusis, and neuropathic pain, this research is relevant to those aspects of the NIH mission aimed at improving health through understanding pathophysiological mechanisms in disorders causing disability.

PI_NAMEs: TZOUNOPOULOS, THANOS  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustic Nerve;Area;Auditory;Auditory area;Auditory Perception;Auditory system;auditory thalamus;awake;Biophysics;Brain;Brain Stem;cell type;Cells;Cochlea;Communication;Complex;Conscious;Detection;Development;disability;Discrimination;Disease;Electrophysiology (science);Esthesia;Exhibits;Health;hearing impairment;Hyperacusis;imaging study;improved;In Vitro;in vivo;in vivo two-photon imaging;Interneurons;Ion Channel;Knowledge;Mediating;Mission;Mus;neuronal circuitry;Neurons;Noise-Induced Hearing Loss;novel;Organ;painful neuropathy;Parvalbumins;Pathway interactions;Perception;Peripheral;pharmacologic;Pharmacotherapy;programs;Property;Pyramidal Tracts;Recovery;rehabilitation paradigm;Research;Role;Schizophrenia;Sensory;sensory cortex;sensory system;Somatostatin;sound;Synapses;System;Testing;Thalamic structure;Time;Tinnitus;two photon microscopy;United States National Institutes of Health;Vasoactive Intestinal Peptide

PROJECT_TITLE: Synaptic, Cellular and Circuit Mechanisms of Cortical Plasticity after Cochlear Damage

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE: PUBLIC HEALTH RELEVANCE STATEMENT Sexual minority youth of color are at increased risk for alcohol and other substance use and misuse than their same-race heterosexual peers. These health disparities are a major public health concern, especially among adolescents, given the economic, societal, mortality, and morbidity burdens. The project will test the effects of sexual minority adolescents of color's long-term and daily experiences with stigma-related stressors related to their minority and stigmatized identities and structural oppression of states they reside on their alcohol and other substance use in their natural environment and over 2.5 years of adolescence, in order to inform and develop interventions and improve the well-being of sexual minority adolescents of color.

PI_NAMEs: MEREISH, ETHAN H. (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;Age;alcohol and other drug;Alcohol consumption;alcohol misuse;alcohol related consequences;alcohol related problem;alcohol risk;alcohol use disorder;alcohol use initiation;Alcohols;Attenuated;children of color;Chronic;Clinical;Clinical assessments;Color;craving;design;Development;diaries;Discrimination;Disparity;Drug usage;Economics;Environment;ethnic minority;ethnic minority population;Ethnic Origin;Etiology;experience;Gays;hazardous drinking;Health;health disparity;Health Priorities;Heterosexuals;improved;innovation;Institutional Policy;Intervention;Knowledge;Laws;lens;Life;marginalization;Measurement;Methodology;Methods;Minority;minority children;minority stress;minority stressor;Modeling;Morbidity - disease rate;mortality;Outcome;peer;Personal Satisfaction;Persons;Play;Population;Prevention;Process;prospective;prospective test;protective factors;Public Health;public health priorities;public health relevance;Race;racial health disparity;racial minority;racial minority population;racism;Research;Research Personnel;Risk Factors;Role;Sampling;Sex Orientation;sexual identity;sexual minority;sexual minority group;sexual minority youth;social stigma;Stigmatization;Stress;stressor;substance misuse;substance use;Testing;theories;Time;Work;Youth

PROJECT_TITLE: Long-term and Daily Associations among Intersectional Minority Stress, Structural Oppression, and Alcohol Use and Misuse among Sexual Minority Adolescents of Color

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurosciences

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: NARRATIVE Dysphagia, or difficulty swallowing, is a common symptom of many neurological diseases but remains poorly understood. In this project, we optimize a multimodal imaging tool using magnetic resonance imaging to provide the unprecedented measurement of both the dynamic motions associated with swallowing, along with the associated neural activity to enhance understanding of swallowing control. This tool will be validated in healthy adults and a sample of patients with neurogenic dysphagia in an effort to improve neurogenic dysphagia characterization and help improve diagnosis and management of this debilitating health condition in the future.

PI_NAMEs: MALANDRAKI, GEORGIA ;SUTTON, BRADLEY P (contact)

PROJECT_TERMS: Adult;Affect;Age;age group;age related;aged;Agreement;Anatomy;Biomechanics;Brain;Brain imaging;Brain Mapping;Clinical;Clinical Management;common symptom;Coupled;Data;Deglutition;Deglutition Disorders;Dehydration;Development;Diagnosis;Diagnostic;diagnostic accuracy;Disease;Endoscopy;Etiology;Event;Foundations;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Future;Goals;Health;Hospitalization;human very old age (85+);Image;imaging approach;Imaging Device;imaging modality;Imaging Techniques;improved;improved outcome;individual patient;insight;Least-Squares Analysis;Life;Link;Magnetic Resonance Imaging;Malnutrition;Maps;Measurement;Measures;Mental Depression;Methods;Modality;mortality;Motion;Multimodal Imaging;multimodality;Nature;Nervous System Disorder;neural;Neurologic;neuromechanism;neurophysiology;neurotransmission;novel;novel strategies;older adult;Oropharyngeal;Outcome;Parkinson Disease;Pathway interactions;Patients;Peripheral;personalized therapeutic;Phenotype;Physiological;Physiology;Population;profiles in patients;Prognosis;Protocols documentation;Quality of life;Rehabilitation therapy;Research;research and development;respiratory;Respiratory Tract Infections;Roentgen Rays;Sampling;Severities;Signal Transduction;Stroke;targeted treatment;Task Performances;Techniques;Technology;technology development;temporal measurement;Therapeutic Intervention;Three-Dimensional Imaging;three-dimensional visualization;Time;tool;Treatment outcome;Visualization;young adult

PROJECT_TITLE: SimulScan: Simultaneous functional and dynamic MRI for evaluating swallowing across age and in neurogenic dysphagia

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF EDUCATION

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Depression is among the most prevalent and impairing forms of psychopathology, with incidence rates sharply increasing in adolescence and earlier age of onset predicting a more debilitating course of depression across the life span. The proposed innovative study examines the neurophysiological markers associated with alterations in emotion regulation that optimize the accurate and generalizable prediction of adolescents’ concurrent depression diagnosis and longitudinal prognosis. The rigorous approach to systematically disentangling neurophysiological markers relevant to emotion regulation and the classification of adolescent depression will further translational clinical research, enhance replicability, and identify novel targets for early intervention and prevention.

PI_NAMEs: DICKEY, LINDSAY  (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Adolescence;Adolescent;Age;Age of Onset;aged;Award;career;child depression;Classification;classification algorithm;Clinical;clinical diagnostics;Clinical Research;clinical translation;clinically relevant;cognitive reappraisal;Complex;Data;Depressed mood;Depressive disorder;depressive symptoms;Development;Diagnosis;Diagnostic;dimension reduction;Disease;Early Intervention;early onset;Electrodes;Electroencephalography;emotion regulation;Emotions;epidemiology study;Event-Related Potentials;experience;Frequencies;Future;Goals;high risk;Image;Impairment;Incidence;indexing;Individual;Individual Differences;individualized prevention;innovation;insight;Intervention;Interview;life span;Literature;Maintenance;Measures;Mental Depression;Methodology;Methods;Modeling;Motivation;multidimensional data;neurophysiology;Neurosciences;Neurosciences Research;novel;Parents;Participant;Patient Self-Report;Performance;personalized intervention;pre-doctoral;Prevention;Principal Component Analysis;Process;Prognosis;prognostic;prospective;Psychopathology;recruit;Recurrence;Refractory;Regulation;Research;Research Personnel;response;Risk;Role;Sampling;Scientist;Sex Differences;statistical learning;Stimulus;Structure;Techniques;Time;Training;Translational Research

PROJECT_TITLE: Identifying Neurophysiological Markers of Emotion Regulation Relevant to Adolescent Depression Diagnosis and Prognosis: A Comparison of Classification Models


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: Project Narrative Our preliminary studies show that proinsulin misfolding occurs during progression to Type 2 diabetes in both humans and mouse. Here we will study human pancreatic islets, as well as genetic models, to undertake biochemical, and pharmacological approaches to understand and promote proinsulin folding as a strategy to ameliorate/prevent Type 2 diabetes.

PI_NAMEs: ARVAN, PETER ;ITKIN-ANSARI, PAMELA ROSE;KAUFMAN, RANDAL J. (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Affect;Animal Model;anterograde transport;Attenuated;Beta Cell;Binding;Biochemical;Biogenesis;Biological Assay;Cell Line;Cell Physiology;Cells;Cessation of life;cofactor;Complex;Confocal Microscopy;crosslink;Data;Development;Diabetes Mellitus;Disease;disulfide bond;Disulfides;Endoplasmic Reticulum;Environment;Epitopes;Failure;Functional disorder;functional loss;gain of function;Genetic;Genetic Models;genome wide association study;Grant;Health;Health Expenditures;Heat-Shock Proteins 70;Homeostasis;Hormones;Human;improved;Individual;Insulin;Insulin Resistance;Intervention;islet;Islets of Langerhans;Link;loss of function;Maintenance;Maps;Measures;Mission;Modeling;Molecular;Molecular Chaperones;Molecular Weight;monomer;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;Oxidoreductase;Pathogenesis;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Physiological;Prediabetes syndrome;Predisposition;prevent;Production;Productivity;Proinsulin;Proteins;Reporter;Reporting;response;Series;Severities;Structure of beta Cell of islet;superresolution microscopy;Time;tool;trafficking;Variant

PROJECT_TITLE: Improving Proinsulin Folding to Ameliorate Type II Diabetes

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ORG_CITY: DETROIT

ORG_DEPT: CHEMISTRY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE With growing concerns regarding the environment and sustainability in the pharmaceutical industry, synthesis of drugs using electricity is emerging as a green and advantageous alternative to traditional synthetic methods because it can cut down on the usage of chemicals, reduce waste, and offer improvements in cost, safety, and sustainability in pharmaceutical production. The first step towards the long-term vision of electrically-driven green synthesis of drugs is to build up an electrosynthetic reaction library. The goal of this proposal is to establish alternating current electrolysis, which uses alternating current to drive chemical reactions, for new reactivities in organic synthesis.

PI_NAMEs: LUO, LONG  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Alternating Current Electrolysis for Organic Synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Continued development of safe and effective novel antidepressants relies on understanding how these drugs modify brain activity. I propose a multi-level approach to investigate actions of a rapid-acting neurosteroid antidepressant at levels ranging from single neurons to brain network activity. These efforts will advance our understanding of how novel antidepressant agents shape complex neurophysiology, and help inform future efforts to produce safe, effective, rapid-acting antidepressants.

PI_NAMEs: LAMBERT, PETER MICHAEL (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Acute;Affect;Allopregnanolone;Anesthetics;anti-depressive agents;antidepressant effect;Brain;career;cell type;Cells;Characteristics;clinical training;clinically relevant;Complex;conditional knockout;Coupled;depressive symptoms;Development;Differentiation Antigens;disability;Disinhibition;Dose;Electroencephalography;Electrophysiology (science);enantiomer;FDA approved;Formulation;Future;genetic manipulation;Goals;hippocampal pyramidal neuron;Hippocampus;improved;In Vitro;in vitro activity;in vivo;inhibitor;Interneurons;Ketamine;Major Depressive Disorder;Measures;Mediating;medical schools;Mental Depression;Mental disorders;Mentorship;Monitor;monoamine;Mus;neural;neural circuit;Neurobehavioral Manifestations;Neurons;neurophysiology;neuropsychiatry;Neurosciences;neurosteroids;new technology;novel;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacology;Pharmacotherapy;Phase;Physicians;Physiological;Population;positive allosteric modulator;Postpartum Depression;Psychotropic Drugs;Pyramidal Cells;receptor;Refractory;reuptake;Role;Scientist;sedative;Series;Shapes;side effect;Slice;Synapses;Techniques;Testing;Training;treatment-resistant depression;United States;Universities;Washington;Whole-Cell Recordings

PROJECT_TITLE: Hippocampal circuit mechanisms of neurosteroids


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Telehealth

PHR: PROJECT NARRATIVE The prevalence of hypertension and cardiovascular related consequences remain high in African Americans (AA), despite treatment advances and evidence-based practice guidelines that have shown positive results in blood pressure control. Mobile Health (mHealth) technologies are promising tools to facilitate behavioral change and sustain self-managing chronic diseases; however, there is a lack of evidence of mHealth long-term impact on clinically relevant health outcomes and data specific to AA older adults. The proposed project will test a technology-based intervention approach, OPtimizing Technology to Improve Medication Adherence and BP Control (OPTIMA-BP), focused specifically on AA older adults with hypertension to improve hypertension self- management, medication adherence, and blood pressure control.

PI_NAMEs: STILL, CAROLYN HARMON (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Adherence;Adult;African American;African American population;Age;American;Anti-Hypertensive Agents;Attitude;Behavior;Behavior Therapy;Behavioral;Blood Pressure;blood pressure control;blood pressure reduction;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cellular Phone;Cessation of life;Chronic;Chronic Disease;Chronic Kidney Failure;Clinical;clinical investigation;clinically relevant;community setting;comparison intervention;Counseling;Data;Diastolic blood pressure;Diet;Disparity;Education;effective therapy;epidemiology study;evidence base;evidence based guidelines;Evidence based practice;Exercise;experience;follow-up;Future;Gender;Goals;Guidelines;Health;health related quality of life;Health Technology;Heart failure;High Density Lipoprotein Cholesterol;Hypertension;hypertension control;hypertension treatment;hypertensive;improved;Individual;innovation;Intervention;Knowledge;Life;Lipids;Literature;Long-Term Effects;Mediating;medication compliance;Medication Management;mHealth;Morbidity - disease rate;mortality;Myocardial Infarction;Nurses;older adult;Online Systems;Outcome;patient oriented;patient-clinician communication;Patients;Pharmaceutical Preparations;Prevalence;Primary Care;primary outcome;prospective;Public Health;Qualitative Evaluations;Quality of life;racial disparity;Randomized, Controlled Trials;Recommendation;Reporting;Research;response;Sampling;Science;secondary outcome;Self Efficacy;Self Management;Serum;skills training;smartphone application;Social support;Stroke;Technology;technology intervention;Testing;Text;Time;tool;Treatment Protocols;trial design;Waiting Lists

PROJECT_TITLE: OPtimizing Technology to Improve Medication Adherence and BP Control (OPTIMA-BP).

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Pediatric;Prevention;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative Degenerative valve diseases are very common and often lead to death. However, we do not understand the mechanisms that underlie the progression of valve diseases. The information generated from this project will provide a better understanding of valve diseases, which may allow for the creation of novel non-invasive therapies able to prevent and heal degenerating valves in children and adults.

PI_NAMEs: WAXMAN, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Ablation;Adult;Affect;Alleles;apoAI regulatory protein-1;Cardiac Surgery procedures;cardiogenesis;Cause of Death;cell type;Cells;Cessation of life;Child;Cilia;Collagen Fiber;Congenital Heart Defects;Coupled;Data;Deposition;Development;Disease;early onset;effective therapy;Elderly;Embryo;Endothelial Cells;Environment;Exhibits;extracellular;Extracellular Matrix;FBN1;Foundations;Frequencies;General Population;Generations;Genes;Genetic;Genetic Epistasis;Genetic Predisposition to Disease;Glycosaminoglycans;healing;Heart;heart defect;Homeostasis;Human;Immune;immune cell infiltrate;improved;Infiltration;Knock-out;Knockout Mice;loss of function;Macrophage;Maintenance;Mammals;mechanotransduction;Methods;Mitral Valve;Mitral Valve Prolapse;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutation;Myocardial dysfunction;Nature;Neonatal;neutrophil;novel;older patient;Operative Surgical Procedures;Orthologous Gene;pharmacologic;Population;postnatal;prevent;Proteins;reconstruction;Regulation;Role;Side;Signal Transduction;single-cell RNA sequencing;T-Lymphocyte;Testing;Therapeutic;Tissues;transcription factor;transcriptome sequencing;transcriptomics;Transgenic Organisms;Tretinoin;valve replacement;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Mechanisms underlying myxomatous valve disease

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Pediatric

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Development of type 2 diabetes (T2D) prior to the age of 20 years has been associated with more aggressive disease progression and earlier dependence on insulin therapy than in adults with T2D. Current recommended first-line treatment for T2D in adolescents (metformin and insulin) does not slow disease progression or effectively reduce elevated body mass index (BMI), one of the primary risk factors for the development and perpetuation of T2D. By studying the effects of an anti-obesity medication (liraglutide 3.0 mg/day) on BMI, insulin sensitivity and beta cell function, this project will contribute the understanding of treatment of T2D in adolescents using a novel BMI-centric approach and weight loss medications.

PI_NAMEs: BENSIGNOR , MEGAN O (contact)

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: 20 year old;Adolescent;Adolescent obesity;Adult;adult obesity;Age;aged;Agonist;Atherosclerosis;Beta Cell;Body fat;Body mass index;Body Weight decreased;career;Cell Physiology;Cells;Childhood;Clinical;Clinical Practice Guideline;Clinical Trials;Clinical Trials Design;comorbidity;comparison control;Data;Dependence;design;Desire for food;Deterioration;Development;Diabetes Mellitus;Disease;Disease Progression;Dose;Endocrinology;Enrollment;Evaluation;FDA approved;Foundations;Functional disorder;Future;GLP-I receptor;Glucagon;glucagon-like peptide 1;Glycosylated hemoglobin A;Goals;Health system;Hypertension;improved;Incentives;Infrastructure;Injectable;insight;Instruction;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;Kidney Diseases;Life Style;liraglutide;Measures;Medicine;Mentors;Metabolic;Metformin;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity in children;obesity treatment;OGTT;open label;Outcome;Participant;patient population;Patients;Pharmaceutical Preparations;Pharmacotherapy;pilot trial;Placebo Control;Placebos;Population;Production;randomized placebo controlled trial;Recommendation;recruit;Refractory Disease;Research;Resources;Risk Factors;Safety;Satiation;sex;skills;slow potential;standard care;standard of care;Training;treatment guidelines;Visceral;Viscosity;Weight Gain

PROJECT_TITLE: Anti-obesity pharmacotherapy to decrease BMI and improve insulin sensitivity in adolescents with obesity and type 2 diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative Although there are many theories, the cause of late onset Alzheimer's disease (LOAD) remains unknown. However, one of the earliest reported perturbations of normal brain function in the pathogenesis of LOAD is disruption of the endosomal-lysosomal network. The goal of this proposal is to quantitate differences induced by LOAD pathogenesis on protein-protein interactions and protein structure within the endosomal-lysosomal network.

PI_NAMEs: YATES III, JOHN R (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta accumulation;Affect;Age;age related;aging population;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease risk;Alzheimer's disease therapy;Amino Acids;amyloid precursor protein processing;analog;Animal Disease Models;Animal Model;Antibodies;Autophagocytosis;baby boomer;Biochemical;Biological;Brain;Brain Diseases;brain tissue;Characteristics;Clinical;cohort;combat;Complex;Dementia;Diagnosis;Disease;Disease Progression;drug candidate;drug development;Drug Targeting;Endosomes;Event;experimental study;extracellular;Foundations;Goals;Healthcare Systems;Hippocampus;Hour;Human;human disease;hyperphosphorylated tau;Immunoprecipitation;in vivo;Individual;Induced pluripotent stem cell derived neurons;Label;Late Onset Alzheimer Disease;Mass Spectrum Analysis;Measurement;Measures;Membrane Proteins;Methionine;Methods;Molecular;Molecular Conformation;Morphology;network dysfunction;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;new therapeutic target;novel;older adult;Older Population;Organoids;Paint;Pathogenesis;Pathologic;Patients;Peptides;Persons;Pharmaceutical Preparations;Phosphorylation;Physiologic pulse;Play;prevent;Protein Analysis;Protein Biosynthesis;protein complex;protein expression;protein folding;protein protein interaction;protein structure;Protein Subunits;Proteins;Quality of life;Reaction;reduce symptoms;Reporting;Research;Resolution;Risk Factors;Role;Sampling;Senile Plaques;small molecule;Solvents;Structure;tau aggregation;tau Proteins;Techniques;Technology;Testing;theories;trafficking

PROJECT_TITLE: Analysis of protein interactions in neurodegenerative disease

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

PHR: We propose to achieve highly comprehensive characterization of the protein composition of extracellular vesicles in human brain tissues, and determine their emerging roles on enhancing neuronal uptake of vesicle associated tau and spread of tau pathology in human induced pluripotent stem cell-derived neurons. The candidate molecules will be specifically targeted by specific antagonistic reagents for their therapeutic potential for halting tau propagation in vivo. These studies will lead to a better understanding of vesicle-mediated disease spread mechanism in Alzheimer's disease and related tauopathy.

PI_NAMEs: IKEZU, TSUNEYA  (contact)

PROJECT_TERMS: Acceleration;Age;aged;Alzheimer's Disease;Alzheimer's disease brain;antagonist;Atomic Force Microscopy;Binding;Biochemical;Bioinformatics;Biological;Biological Assay;Biomedical Engineering;Biosensor;Brain;brain control;brain tissue;C57BL/6 Mouse;candidate identification;case control;Cells;chronic traumatic encephalopathy;Clinical Pathology;comparison control;corticobasal degeneration;Data;Data Set;Databases;differential expression;Disease;Disease Progression;Endocytosis;Energy Transfer;Enzyme-Linked Immunosorbent Assay;Evaluation;exosome;extracellular vesicles;Fortification;Foundations;Gene Silencing;Genes;Goals;gray matter;Hippocampus;Human;human induced pluripotent stem cells;In Vitro;in vitro activity;in vitro Assay;in vivo;Induced pluripotent stem cell derived human neuron;Inflammation;Injections;Lewy Body Dementia;Machine Learning;Mass Spectrum Analysis;Mediating;Methods;Microscopy;Microtubule-Associated Proteins;microvesicles;Molecular;Molecular Conformation;Molecular Target;mouse model;multi-electrode arrays;multidisciplinary;Mus;Neurofibrillary Tangles;Neurons;non-demented;Pathogenicity;Pathologic;Pathology;Phosphorylation;Post-Translational Protein Processing;Progressive Supranuclear Palsy;Property;protein protein interaction;Proteins;Proteome;Proteomics;Reagent;recruit;Research Personnel;Role;Sampling;sensor;sex;Small Interfering RNA;Specimen;Symptoms;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;Transfection;transmission process;Treatment Efficacy;uptake;Vesicle

PROJECT_TITLE: Molecular characterization of extracellular vesicles for the spread of misfolded tau protein

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND-M]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

PHR: PROJECT NARRATIVE The ability of lymphocytes (white blood cells) to provide local immunity, but also their pathogenic role in diseases from atherosclerosis to cancer and autoimmune disorders, requires their migration from the blood into target tissues through specialized blood vessels, exemplified by the high endothelial venules (HEV). HEV are induced in immunized lymphoid tissues and in tumors and sites of chronic tissue inflammation, but what controls their generation and their role in disease has been unclear. Our studies will define mechanisms that control HEV generation and specialization, and may lead to new ways to enhance vaccine and tumor responses and control inflammatory diseases through therapeutic manipulation of these vascular entry sites for lymphocyte recruitment.

PI_NAMEs: BUTCHER, EUGENE C (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;angiogenesis;Apoptosis;Atherosclerosis;Atlases;Autoimmune Diseases;autoimmune inflammation;Biological Assay;Blood;Blood capillaries;Blood Vessels;candidate identification;Capillary Endothelial Cell;Cell Fate Control;Cell Physiology;Cells;Chronic;Complement;Cytometry;Development;Disease;Down-Regulation;draining lymph node;endonuclease;Endoplasmic Reticulum;endoplasmic reticulum stress;Endothelial Cells;Endothelium;Fluorescence;Gene Expression;Gene Expression Profiling;gene function;Gene Mutation;Gene Targeting;Generations;Genes;Genetic Transcription;Goals;Golgi Apparatus;Grant;Gut associated lymphoid tissue;high dimensionality;High Endothelial Venule;Homeostasis;Homing;Human;Image;Immune;Immune response;Immunity;Immunization;Immunize;immunoregulation;In Situ;Inflammation;Inflammatory;Informatics;innovation;insight;Knowledge;Leukocytes;lymph nodes;Lymphocyte;Lymphoid Tissue;Malignant Neoplasms;Metabolism;Methods;migration;Molecular;molecular phenotype;Morphology;mouse model;Mus;Myelogenous;Myeloid Cells;nanoparticle;notch protein;notch-2 protein;novel;novel therapeutic intervention;Pathogenicity;Pathologic;Pathology;Pathway interactions;Phenotype;Physiological;postcapillary venule;progenitor;programs;Proliferating;Proteins;Proteomics;RANK protein;recruit;Regulation;response;Role;role model;Secretory Cell;segregation;Signal Transduction;single-cell RNA sequencing;Site;stem cell homeostasis;stem cells;Testing;Therapeutic;Tissues;trafficking;Transcriptional Regulation;tumor;Tumor Immunity;Up-Regulation;Vaccination;Vaccines;Venous;XBP1 gene

PROJECT_TITLE: Progenitor Cells for High Endothelium in the Immune Response


NIH_SPENDING_CATS: Aging;Clinical Research;Diabetes;Genetics;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Diabetes is a leading risk factor for the global burden of disease, and there is an urgent need to better understand this collection of diseases. This proposal aims to define the molecular profile of a subset of diabetes resulting from a human pathogenic variant of MAFA, a fundamental pancreatic islet-enriched transcription factor differentially expressed in mice and humans. These studies will identify β-cell signatures with special emphasis on sex-dependent differences, such as male cellular senescence, in hopes of identifying new therapeutic strategies and targets.

PI_NAMEs: CHA, JEEYEON  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: 10 year old;Acute;Adult;age related;aged;Aging;American;Apoptosis;Automobile Driving;B-Lymphocytes;Beta Cell;Birth;Blood Glucose;blood glucose regulation;Bromodomains and extra-terminal domain inhibitor;burden of illness;Cell Aging;Cell Cycle Regulation;Cell Physiology;Cells;Characteristics;Chronic;Chronic Disease;Classification;Collection;Curiosities;Data Set;Development;Diabetes Mellitus;Diagnosis;differential expression;Disease;disease-causing mutation;DNA Sequence Alteration;Exhibits;Family;Female;Functional disorder;Gene Expression;Gene Modified;Glucose;Glucose Intolerance;Health;healthy aging;Heterogeneity;Hormones;Human;human disease;human female;Hyperglycemia;Hypoglycemia;Immunocompromised Host;Impairment;improved;in vivo;Individual;individualized medicine;insight;Insulin;insulin secretion;insulinoma;Investigation;islet;Islet Cell;Islets of Langerhans;Life;Link;male;Malignant Neoplasms;Mature B-Lymphocyte;Mediating;men;Metabolism;Minor;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutation;Myocardial Infarction;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Pancreas;Pathogenicity;pathological aging;Patients;Phenotype;Phenylalanine;Physiological;Point Mutation;Population;Positioning Attribute;postnatal;premature;Premature aging syndrome;preservation;Production;Property;Proteins;Publishing;Resistance;response;Risk Factors;Rodent Model;senescence;senescence associated secretory phenotype;Serine;sex;Sex Bias;Sex Differences;sexual dimorphism;Signal Transduction;single-cell RNA sequencing;Stroke;Structure of beta Cell of islet;Technology;Testing;therapy development;Transcription Coactivator;transcription factor;transcriptomics;Transplantation;Treatment Failure;Variant;Woman;Work

PROJECT_TITLE: Examining how the novel S64F MAFA variant produces glucose intolerance or hypoglycemia in a sex-dependent manner


ADMINISTERING_IC: HG

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative: In order to understand complex biological and disease processes a number of highly valuable rat models have been developed. These models take advantage of natural genetic variation to provide a platform to study these processes. Since this genetic variation is embodied within the genomes of these rat models, a full understanding of the link between genetics and biology of disease cannot be reached without full knowledge of the genomes of animals providing these models. We will use new genome sequencing, assembly and scaffolding methods and we will provide annotated genome assemblies for 9 important rat strains that contribute to numerous genetic models of disease.

PI_NAMEs: DORIS, PETER A (contact);KALBFLEISCH, THEODORE ;SMITH, MELISSA LAIRD

PROGRAM_OFFICER_NAME: WETTERSTRAND, KRIS A

PROJECT_TERMS: Addictive Behavior;Affect;Agriculture;Alternative Splicing;Amylases;Animal Model;Animals;Automated Annotation;base;Behavior;Behavioral;Behavioral Research;Biodiversity;Biological;Biological Process;Biology;Biomedical Research;Brain;Brain Diseases;Carbohydrates;Cardiovascular Physiology;Characteristics;Chromosomes;Communities;comparative;Complex;cost;Data;Deposition;Development;Diet;Digestion;Disease;disease model;Disease susceptibility;disorder risk;Distant;Drug Addiction;Elements;Ensure;Event;Evolution;Experimental Models;Funding;Gene Duplication;Gene Expression;Genes;Genetic;Genetic Diseases;Genetic Models;Genetic Variation;Genome;genome annotation;genome resource;genome sequencing;Genomic DNA;genomic tools;genomic variation;Genomics;Grain;Hi-C;Human;hypertensive;IGH@ gene cluster;Inbred BN Rats;Inbred Strains Rats;Inbreeding;Investigation;Knowledge;Laboratories;Libraries;Ligation;Link;Liquid substance;Long-Evans Rats;mammalian genome;Manuals;Maps;Medical;Methods;Modeling;Molecular Conformation;mRNA sequencing;Mus;Nature;Neurosciences;normotensive;Norway;Optics;Organism;Pathogenesis;Phenotype;Physiology;Polishes;Process;Proteins;rat genome;Rat Genome Database;Rat Strains;Rattus;Rattus norvegicus;reference genome;Renal function;Research;Research Personnel;Resources;Rodent;Sampling;scaffold;single molecule;Single Nucleotide Polymorphism;Socialization;Starch;Structure;System;Tissues;trait;Transcript;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Variant;whole genome;Work;X Inactivation

PROJECT_TITLE: Long-read assembly and annotation of rat genomes that are important models of complex genetic disease

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Nanotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Traumatic Brain Injury (TBI) is a major global and domestic health issue. We have found that Immune-modifying nanoParticles (IMP) are a strong candidate for a clinically translatable acute pharmacologic intervention for TBI. The proposed studies will help to understand the mechanisms underlying the protective effects of IMP and help to develop a potentially effective practical therapy for human TBI.

PI_NAMEs: KESSLER, JOHN A (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acceleration;Accident and Emergency department;Acids;Acute;Address;Affect;American;Anatomy;Attenuated;Behavior;behavior influence;Binding;Biopolymers;Bone Marrow;Brain;Brain Injuries;brain tissue;carboxylate;Cell Lineage;cell type;Cells;Charge;chemokine;clinical translation;Clinical Trials Design;Cognitive;Complement;Complex;cytokine;designer receptors exclusively activated by designer drugs;Diameter;Edema;excitotoxicity;Experimental Models;experimental study;FDA approved;Gene Expression;Gliosis;Health;Hematogenous;Hippocampus;Hour;Human;Immune;immune cell infiltrate;improved outcome;Infiltration;Inflammation;Inflammatory;Injury;Intervention;Intravenous;intravenous administration;Label;Lead;Macrophage;Mediating;Microglia;Modeling;Molecular;monocyte;Motor;Mus;nanoparticle;neurogenesis;Neuroglia;neuronal survival;Neurons;particle;Persons;pharmacologic;Physiological;Population;preclinical trial;preservation;prevent;Process;protective effect;Reactive Oxygen Species;receptor;Recovery;Role;Seizures;single-cell RNA sequencing;Site;Spleen;stem cell proliferation;stem cells;Structure;Synapses;TBI treatment;Temperature;therapeutic development;therapeutically effective;Time;tool;Translations;Traumatic Brain Injury;Travel;Vascular Endothelial Cell;Visual

PROJECT_TITLE: Immune-modifying nanoparticles for the treatment of traumatic brain injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE Slowing the ultimate clinical expression of Alzheimer disease (AD) will likely require understanding and treating the factors that influence early brain pathology, before the illness progresses to dementia, such as in amnestic mild cognitive impairment (aMCI). This project aims to test the efficacy and safety of transcranial photobiomodulation (t-PBM) over 8 weeks compared to sham in improving clinical symptoms of aMCI. By evaluating the efficacy of t-PBM, an innovative, non-invasive technology with a well-established safety profile, and by exploring the association of t-PBM treatment effects with important biomarkers relevant for AD illness progression, this study will be a key first step in developing a novel, easy to administer neuromodulation treatment for aMCI and for AD.

PI_NAMEs: CASSANO, PAOLO ;IOSIFESCU, DAN VLAD (contact);OSORIO, RICARDO S

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: absorption;Acute;acute stroke;Adenosine Triphosphate;Adverse event;Age;Alzheimer disease prevention;Alzheimer's Disease;amnestic mild cognitive impairment;Animal Model;antidepressant effect;Antioxidants;Bilateral;Bioenergetics;Biological Markers;biomarker development;biomarker validation;Blood flow;blood oxygen level dependent;Brain;Brain Pathology;Case Series;Cephalic;Cerebral cortex;Cerebrovascular Circulation;Clinical;clinical development;Cognition;Cognitive deficits;cognitive function;cost;cytochrome c oxidase;Data;Dementia;Devices;dietary supplements;Disease;dosage;Dose;Double-Blind Method;Early Intervention;efficacy evaluation;efficacy outcomes;efficacy testing;Electrodes;Electroencephalography;Feeling suicidal;Forehead;Functional Magnetic Resonance Imaging;Future;General Hospitals;glucose metabolism;Goals;Human;improved;Individual;innovation;Intervention;Lasers;Light;Literature;magnetic resonance spectroscopic imaging;Major Depressive Disorder;Massachusetts;Measures;Mediator;Memory;Metabolic Pathway;Mitochondria;Monitor;neuroimaging;Neuropsychological Tests;Neuropsychology;neuroregulation;New York;novel;Oxidative Phosphorylation;Parkinson Disease;Participant;Patients;Penetration;Phase;photobiomodulation;Physiologic pulse;Population;Positioning Attribute;Positron-Emission Tomography;pre-clinical;Prefrontal Cortex;Prevalence;primary outcome;prodromal Alzheimer's disease;Production;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Reactive Oxygen Species;Reporting;Respiratory Chain;Safety;secondary outcome;Signal Transduction;Site;sleep quality;stroke patient;Symptoms;tau Proteins;Technology;Testing;therapeutic target;treatment effect;treatment response;Universities;user-friendly;Vitamins

PROJECT_TITLE: Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD)


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE  Pathological anxiety, which remains one of the most common forms of mental illness, tends to emerge during early adolescence and does so to a greater degree in girls than boys. The object of this proposal is to identify the adolescent- and sex-specific biological mechanisms that increase risk for anxiety during adolescence, with a focus on testosterone and myelination of prefrontal-subcortical circuits. This research has the potential to significantly impact public health by identifying developmental pathways that increase risk for anxiety, which will enhance the identification and treatment of at-risk kids before trajectories crystalize.

PI_NAMEs: SPIELBERG, JEFFREY MARTIN (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Development;Affect;Affective;Amygdaloid structure;Anxiety;Anxiety Disorders;Area;Axon;Biological;Biological Assay;biomarker identification;boys;Brain;Child;Coupling;Data;Development;Developmental Course;Diffusion;disability;early adolescence;Effectiveness;emotion dysregulation;emotion regulation;endophenotype;Evaluation;Exposure to;Family history of;Female;follow-up;Functional Magnetic Resonance Imaging;Future;girls;Heritability;high risk;Home environment;Hormonal;Hormones;Individual;Intervention;Link;Literature;Longitudinal Studies;male;Measures;Mediating;Mental disorders;Methods;Modeling;multimodality;Myelin;myelination;neural;neural circuit;neurobiological mechanism;neuroimaging;novel;Parents;Pathological anxiety;Pathology;Pathway interactions;Phenotype;predictive marker;Predisposing Factor;Process;Puberty;Public Health;recruit;Regulation;Research;Risk;Risk Factors;Role;Sampling;sex;Sex Differences;Siblings;Stimulus;Structure;support network;symptomatology;Testing;Testosterone;Time;white matter;Work

PROJECT_TITLE: Testing a Dual Mechanism Model of Adolescent Anxiety Development & Related Sex Differences

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Neurosciences;Prostate Cancer;Urologic Diseases

ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Nerve-sparing radical prostatectomy is the primary treatment option for prostate cancer, however delineation between tumor and nerve tissue in the operating room continues to challenge even experienced surgeons. This difficulty leaves patients with tumor positive margins and nerve damage resulting in mortality and morbidity, respectively. Herein, we will develop a two-color fluorescence guided surgery solution that will enable ready differentiation between tumor and nerve tissue in the operating room for future clinical translation to improve surgical outcomes.

PI_NAMEs: GIBBS, SUMMER LYNNE (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Adverse effects;Affect;Affinity;Antigen Targeting;Biodistribution;Cancer Control;Cancer Etiology;cancer imaging;Cancer Patient;Cessation of life;chromophore;Clinical;Clinical Medicine;clinical translation;clinically relevant;Collaborations;Color;comorbidity;contrast imaging;Contrast Media;Development;Dose;Dose Limiting;Drug Kinetics;experience;Face;falls;FDA approved;Fluorescence;fluorescence imaging;fluorescence-guided surgery;fluorophore;FOLH1 gene;Future;Goals;Image;Impotence;improved;Incontinence;Intuition;Label;Lead;Light;Malignant neoplasm of prostate;Malignant Neoplasms;men;Methods;Morbidity - disease rate;mortality;Nerve;nerve damage;Nerve Plexus;Nerve Tissue;Nerve-Sparing Prostatectomy;novel;Nude Rats;Operating Rooms;Operative Surgical Procedures;Outcome;overexpression;Patient-Focused Outcomes;Patients;Pharmacodynamics;Pharmacology and Toxicology;Phase I Clinical Trials;Postoperative Period;pre-clinical;preclinical safety;preservation;Prostate;Prostate Cancer therapy;Prostatectomy;Prostatic;prototype;Quality of life;Robot;robot assistance;Rodent;Safety;small molecule;spared nerve;Specificity;Surgeon;surgery outcome;Surgical margins;System;Technology;Time;Tissues;tool;Toxic effect;Toxicology;Translations;tumor;Tumor Tissue;Visual Acuity;Visualization;Water;Work;Xenograft procedure

PROJECT_TITLE: Multichannel Fluorescence Guided Surgery Tools Enabling Simultaneous Cancer Margin and Nerve Visualization in Prostatectomy

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: ––– PROJECT NARRATIVE ––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––– Alcohol abuse disorders are a chronic human condition where initial consumption leads to long lasting behavioral changes, including tolerance to repeat exposure. The results of the proposed studies will provide valuable mechanistic insight into the initial levels of response to alcohol and into the development of tolerance. This will highlight novel targets for therapeutic intervention with alcohol addiction, which are largely lacking.

PI_NAMEs: ROTHENFLUH, ADRIAN  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Alcohol abuse;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol response;alcohol sensitivity;alcohol use disorder;Alcohols;Amygdaloid structure;Anatomy;ATAC-seq;Behavioral;Binding;Binding Sites;Biological Assay;Biological Process;Brain;Chromatin;chromatin modification;Chronic;Cleavage Under Targets and Release Using Nuclease;combinatorial;comparison control;Complex;Consumption;Data;demethylation;Dependence;Development;Disease;DNA;Drosophila genus;Enhancers;Enzymes;Epigenetic Process;Ethanol;Ethanol dependence;experimental study;Face;fly;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic approach;genetic manipulation;Genetic Transcription;Genetic Variation;Genome engineering;Genomics;Goals;histone demethylase;histone methylation;histone modification;Histones;Human;improved;Individual;individual variation;insight;interest;Intoxication;Knock-out;Lysine;Mammals;marijuana use;Mediating;Methylation;Molecular;mutant;N-terminal;National Institute on Alcohol Abuse and Alcoholism;neural;neural circuit;Neurons;neuroregulation;Neurotransmitters;new therapeutic target;Orthologous Gene;Outcomes Research;problem drinker;promoter;Publishing;Regulation;Resistance;response;Risk Factors;Role;Sedation procedure;sedative;Surveys;System;Testing;Therapeutic Intervention;Tissues;transcription factor;Transcription Process;Transcriptional Regulation;translation to humans;vinegar fly;Vulnerable Populations

PROJECT_TITLE: Transcriptional Regulation of Alcohol Sensitivity and Tolerance

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Methamphetamine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative HIV infection and methamphetamine abuse remain substantial public health concerns and despite the availability of antiretrovirals (ARVs) and combined ARV therapy (cART). While cART has shifted the overall picture of HIV-1 disease by providing significant benefits the virus cannot be eliminated and persists. Methamphetamine abuse is known to increase the risk of contracting HIV-1 and the psychostimulant seems to directly affect viral load. The purpose of the proposed research is to better understand the cellular and molecular mechanism underlying the compromising effect of the psychostimulant on cART-dependent optimal viral suppression in order to better counter viral persistence and recrudescence.

PI_NAMEs: KAUL, MARCUS  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Age;Anti-Retroviral Agents;antigen processing;antiretroviral therapy;Blood;Blood Cells;CD34 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Line;Cell Physiology;Cells;cellular targeting;Collaborations;Contracts;Data;Dendritic Cells;Development;Disease;DNA;drug of abuse;Engraftment;epigenetic regulation;exhaustion;experimental study;Gene Expression;Gene Expression Regulation;genetic regulatory protein;Glycoproteins;Hematopoietic stem cells;Hematopoietic System;HIV;HIV Envelope Protein gp120;HIV Infections;HIV-1;Human;humanized mouse;Immune;improved;In Vitro;in vivo;in vivo Model;Individual;Infection;infection risk;Interruption;IRF1 gene;knock-down;Lead;Link;link protein;Macrophage;Methamphetamine;methamphetamine abuse;methamphetamine effect;methamphetamine exposure;methamphetamine use;Microglia;Mitogen-Activated Protein Kinases;Molecular;Monitor;monocyte;mouse model;Nucleotides;p38 Mitogen Activated Protein Kinase;Pathologic;Patients;Peripheral;Peripheral Blood Lymphocyte;permissiveness;Phagocytosis Inhibition;Pharmaceutical Preparations;Physiological;prevent;Proliferating;promoter;protein expression;Protein Kinase;psychostimulant;Public Health;RANTES;receptor;Recrudescences;Recurrence;Regulator Genes;Reporting;Research;Risk;Risk Behaviors;RNA;Role;Signal Transduction;stem cell engraftment;stimulant abuse;Stress;T-Cell Activation;T-Lymphocyte;Testing;Trans-Activators;Transcription Coactivator;transcriptome sequencing;Untranslated RNA;Up-Regulation;Viral;Viral Load result;Viral reservoir;Virus;Virus Replication;Withholding Treatment

PROJECT_TITLE: Methamphetamine Effect on HIV Persistence

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Asthma;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Lung

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative We hypothesize that airway mucus plugs are an under-appreciated cause of airflow obstruction in severe forms of asthma and that muco-active treatment in mucus plug-high asthma will improve airflow in these patients. We further hypothesize that intelectin has a pivotal role in mediating airway mucus plug formation in asthma.

PI_NAMEs: FAHY, JOHN V (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Acetylcysteine;Adrenal Cortex Hormones;Air Movements;airway epithelium;airway inflammation;airway obstruction;Amino Acids;Applications Grants;Asthma;asthmatic patient;Binding;biobank;Biological;Biological Assay;Biological Markers;Biology;biophysical properties;Biophysics;Bronchoscopy;C-terminal;Cells;Charge;Clinical Trials;cohort;Collaborations;Computer Vision Systems;convolutional neural network;CRISPR/Cas technology;Cross-Over Trials;crosslink;Cysteine;cytokine;Cytolysis;Data;design;Diameter;Disease;Disulfides;Doctor of Philosophy;Dose;drug development;druggable target;Elasticity;Electrostatics;eosinophil;Epithelial Cells;experimental study;Formulation;Functional disorder;Gel;Genes;Genetic Polymorphism;Heparin;Human;Image;image processing;improved;In Vitro;Inflammation;Inhalation;Interleukin-13;knock-down;Knowledge;Length;Location;Low Dose Radiation;lung imaging;Maps;Measures;Mediating;Medical;Methodology;Molecular;Monitor;MUC5AC gene;Mucins;Mucolytics;Mucous body substance;neural network architecture;novel;novel strategies;novel therapeutics;Oral;Participant;Pathology;Pathway interactions;Patient imaging;Patients;Pharmaceutical Preparations;Phenotype;phenotypic biomarker;Placebo Control;Polymers;predictive marker;Predisposition;programs;Protein Secretion;Proteins;Protocols documentation;Publishing;pulmonary function;radiologist;Randomized;Research;Research Personnel;Resources;response;response biomarker;Rheology;Risk;Role;Route;segmentation algorithm;Severities;Shapes;Sodium Chloride;Sputum;System;Tail;Techniques;Technology;Testing;Therapeutic;therapeutic protein;Time;Training;Trees;Variant;X-Ray Computed Tomography

PROJECT_TITLE: Phenotypic and biological features of mucus plugs in asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related

ORG_CITY: EAST LANSING

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project Narrative The project concerns the development of genomics, artificial intelligence, biophysics, mathematics, and experiment-based platform for the prediction of vaccine-escape mutations and design of mutation-proof antibodies. This development is of life-saving importance.

PI_NAMEs: WEI, GUOWEI  (contact);ZHENG, YONG-HUI

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;ACE2;Affinity;algebraic topology;Antibodies;antibody libraries;Antibody Therapy;Antigens;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Artificial Intelligence platform;base;Binding;Biophysical Process;Biophysics;Categories;Cells;Cessation of life;Clinical Trials;Computer Assisted;Country;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 vaccination;Data;Databases;Deposition;design;Development;differential geometry;drug discovery;early phase clinical trial;efficacy validation;Elements;Emergency Situation;Evolution;experimental study;flu;Future;future pandemic;Generations;Genes;Genome;Genomics;Genotype;Goals;Graph;improved;Induced Mutation;Infection;influenza virus vaccine;innovation;Libraries;Life;Literature;mathematical algorithm;Mathematics;Methodology;Methods;Modeling;Molecular;Mutagenesis;Mutate;Mutation;Natural Selections;next generation;novel vaccines;pandemic disease;Patients;Pattern;Pharmaceutical Preparations;Phase;Play;Population;predictive modeling;Prevention Measures;Probability;programs;Property;Proteins;Race;receptor;receptor binding;Research Personnel;SARS-CoV-2 antibody;SARS-CoV-2 genome;SARS-CoV-2 spike protein;SARS-CoV-2 variant;seasonal influenza;Series;software development;Structure;success;Testing;theories;Therapeutic antibodies;tool;Training;user friendly software;user-friendly;Vaccine Therapy;Vaccines;Validation;Variant;Viral;Viral Vaccines;Virus;Work

PROJECT_TITLE: AI-based platform for predicting emerging vaccine-escape variants and designing mutation-proof antibodies

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Precision Medicine;Prevention;Rare Diseases;Scleroderma

ORG_CITY: BALTIMORE

ORG_DEPT: DERMATOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research will establish a comprehensive, prospective myopathy cohort in systemic sclerosis (SSc or scleroderma) to ultimately devise a novel classification schema for SSc-associated myopathy that is predictive of outcomes such as treatment response, disability, cardiopulmonary disease trajectory, and death. Advanced muscle MRI techniques include diffusion weighted imaging, diffusion tensor imaging, and T2 mapping will also be used to detect and quantify early muscle disease related changes in SSc associated myopathy. The knowledge gained from this study will lay the foundation for discovering predictive biomarkers of disease course and to allow future studies of the specific biological process involved in each phenotype.

PI_NAMEs: PAIK, JULIE JISUN (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Address;Advisory Committees;Age;Algorithms;Biological;Biological Process;Biopsy;Cardiac Death;career;Cessation of life;Chronic;Classification;Clinical;clinical development;clinical epidemiology;Clinical Investigator;Clinical Trials;clinically significant;cohort;Consensus;Creatine Kinase;Data;Development;Diffusion Magnetic Resonance Imaging;diffusion weighted;disability;Disease;disorder control;Early Diagnosis;Early identification;Edema;Electromyography;Enrollment;epidemiology study;Fatty acid glycerol esters;Fibrosis;Foundations;Future;Gender;Goals;Heterogeneity;high risk;Histologic;Histopathology;illness length;Image;imaging biomarker;Imaging Techniques;Incidence;Inclusion Body Myositis;Individual;Inflammation;Inflammatory;Infrastructure;interest;International;Intramuscular;Knowledge;Laboratories;Logistic Regressions;Magnetic Resonance Imaging;Manuals;Maps;Measures;Medicine;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Metabolic;Methodology;Methods;Modeling;mortality;Muscle;muscle form;muscle strength;Muscle Weakness;Musculoskeletal;Myopathy;Myositis;Necrosis;novel;observational cohort study;Outcome;Outcome Measure;outcome prediction;Pathogenesis;Pathologic;Patients;Pattern;Phenotype;Prediction of Response to Therapy;predictive marker;Process;professor;prospective;Prospective cohort;Protocols documentation;Pulmonary Heart Disease;quantitative imaging;radiological imaging;Radiology Specialty;random forest;recruit;Research;Resources;Retrospective Studies;Rheumatology;Sampling Biases;Scleroderma;Serology;Signal Transduction;skeletal;Skeletal Muscle;skills;Systemic Scleroderma;Techniques;Testing;Therapeutic;Therapeutic Trials;Translational Research;Treatment outcome;treatment response;Universities;uptake;Validation

PROJECT_TITLE: Skeletal Myopathy in Systemic Sclerosis: Devising a Classification Schema Predictive of Outcomes

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative The Ocular Hypertension Treatment Study is the only US study with 20-years of clinical and vision- related quality of life outcomes in a cohort of 1,636 participants. The 20 year follow-up is meaningful because it approaches the life expectation of participants whose age was 55 at baseline. We will analyze the long-term effect of treatment, clinical and demographic factors on vision-related quality of life. Results from this study will provide a unique opportunity to understand the long-term patient burden of ocular hypertension and glaucoma.

PI_NAMEs: GAO, FENG ;GORDON, MAE O (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Affect;Age;age effect;Automobile Driving;Benefits and Risks;Cessation of life;Clinical;cohort;Cohort Studies;Contrast Sensitivity;Control Groups;Cross-Sectional Studies;Data;Demographic Factors;Diagnosis;expectation;Eye;follow-up;Glaucoma;Health;hypertension treatment;improved;indexing;Individual Adjustment;Individual Differences;Life;Life Expectancy;Long-Term Effects;longitudinal analysis;Longitudinal cohort;Measures;National Eye Institute;Ocular Hypertension;Ophthalmology;Outcome;Participant;Patients;Primary Open Angle Glaucoma;Protocols documentation;Quality of life;Questionnaires;rate of change;Reading;Reporting;Sampling;secondary analysis;Surveys;Testing;treatment effect;United States Preventative Services Task Force;Vision;Visit;Visual Acuity;Visual Fields;Visual impairment;Walking

PROJECT_TITLE: Long-Term Quality of Life in the Ocular Hypertension Treatment Study Cohort


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE The proposed study aims to prove that it is possible to measure change in brain structures in people with Alzheimer’s disease or Frontotemporal Lobar Degeneration over intervals much shorter than typical in the field (as short as 3 months). Capitalizing on recent advances in fast brain scanning methods, we have collected pilot data in a few patients showing that we can precisely measure change in each individual within 3-month intervals. If we show that this can be done in a larger group of patients with a diverse array of dementias, this will pave the way for these methods to be used in large natural history studies or clinical therapeutic trials.

PI_NAMEs: DICKERSON, BRADFORD C (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Acceleration;Alzheimer's Disease;Amyloid;Anatomy;Atrophic;behavioral variant frontotemporal dementia;Biological;Biological Markers;Brain;brain cell;brain magnetic resonance imaging;Brain region;Brain scan;brain size;brain volume;cerebral atrophy;Cessation of life;Clinical;Clinical Trials;Clinical Trials Design;Cross-Over Trials;Data;Dementia;Detection;Diagnosis;Disease;early onset;Early Onset Alzheimer Disease;Family;fluorodeoxyglucose positron emission tomography;Foundations;Frontotemporal Lobar Degenerations;Goals;imaging facilities;improved;in vivo;Individual;interest;Investigation;Knowledge;Lobar;Location;Magnetic Resonance Imaging;Maps;Measurable;Measurement;Measures;Methodology;Methods;Monitor;MRI Scans;Multicenter Studies;Natural History;Nerve Degeneration;neurodegenerative dementia;Neurodegenerative Disorders;novel;novel strategies;Outcome;Participant;Patients;Persons;phase III trial;Positron-Emission Tomography;Public Health;regional atrophy;Research;Running;Sample Size;Sampling;scale up;Scanning;Site;standard measure;Structure;Syndrome;tau Proteins;Techniques;Technology;Therapeutic Trials;Thick;Time;time interval;trial design;Validity and Reliability;Work

PROJECT_TITLE: Robust detection of atrophy over short intervals in AD and FTLD

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Data Science;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Pancreatic Cancer;Prostate Cancer;Radiation Oncology;Rare Diseases;Urologic Diseases

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Leveraging deep learning for markerless motion management in radiation therapy Project Narrative This project is aimed at establishing a deep learning-based image guidance strategy for motion management in prostate and pancreas radiation therapy. Successful completion of this investigation will significantly advance the current beam targeting technique and provide radiation oncology discipline a powerful way to safely and reliably escalate the radiation dose for precision radiation therapy. The research should thus lead to a widespread impact on the management of various neoplasmic diseases affected by organ motion.

PI_NAMEs: XING, LEI  (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: 3-Dimensional;Affect;Brain;cancer type;Clinical;Complication;cone-beam computed tomography;conventional therapy;convolutional neural network;cost;Data;Data Set;deep learning;deep learning algorithm;deep learning model;Detection;Development;Discipline;Disease;Dose;Duodenum;experimental study;Head and neck structure;Hemorrhage;Image;image guided;image guided intervention;image guided radiation therapy;Implant;improved;indexing;Infection;Intensity-Modulated Radiotherapy;Investigation;Lead;Learning;Liver;Location;Lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Methods;Modeling;Modernization;Modification;Monitor;Motion;Nature;Neoplasms;Normal tissue morphology;novel;Organ;Pancreas;pancreas imaging;pancreas radiation therapy;Patient Care;Patients;Performance;Positioning Attribute;predictive modeling;Probability;Procedures;Process;Prostate;Prostate Cancer therapy;Radiation Dose Unit;Radiation Oncology;Radiation therapy;Radiosurgery;real time model;Research;respiratory;Retrospective Studies;Roentgen Rays;Site;System;Techniques;Time;Training;training data;treatment planning;tumor;Uncertainty;Vertebral column;Visualization;X-Ray Computed Tomography;X-Ray Medical Imaging


NIH_SPENDING_CATS: Genetics

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative These studies will lead to a better understanding of gene regulation, and will therefore provide new insights into the molecular basis and potential treatment of human diseases, such as many forms of cancer, that involve defects in the proper control of gene expression.

PI_NAMEs: KADONAGA, JAMES T. (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Affect;Animals;Area;Binding;Biological Phenomena;Biological Sciences;cancer prevention;Cell Nucleus;Cell Physiology;Chromatin;Chromatin Structure;Complex;Defect;DNA;DNA Damage;DNA Sequence;DNA Structure;Elements;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Materials;Genetic Transcription;Goals;Human;human disease;insight;interest;Knowledge;Malignant Neoplasms;Mediating;Molecular;Nucleosomes;Organism;Positioning Attribute;Process;programs;promoter;Reactive Oxygen Species;Regulation;Research;RNA Polymerase II;Signal Transduction;Site;Stretching;System;transcription factor;Transcription Initiation;Transcription Process;Transcriptional Regulation;Work

PROJECT_TITLE: Mechanisms of Eukaryotic Gene Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Genetics;Nutrition;Precision Medicine;Prevention

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Type 2 diabetes (T2D) can be successfully prevented or delayed in high-risk individuals with behavioral or pharmacologic intervention, however, there is a significant amount of inter-individual differences in the effect of these treatments. The goal of this proposal is to identify new molecular pathways involved in the development of diabetes—some of which could modulate the effect of preventive interventions—through integrating genetics, metabolomics, and clinical phenotypes and endpoints from a completed randomized control trial of diabetes prevention treatments. In parallel with these aims, a pilot prospective cohort study is proposed to externally validate these metabolites as biomarkers for incident T2D and glycemic traits in a real-world population of individuals with prediabetes that will provide a framework for a future clinical biomarker trial.

PI_NAMEs: CHEN, ZSU-ZSU  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Adult;Advisory Committees;Aromatic Amino Acids;Behavior Therapy;Behavioral;Biological Markers;biomarker discovery;blood glucose regulation;burden of illness;Cardiometabolic Disease;career development;Cholesterol Esters;Clinical;clinical biomarkers;clinical decision-making;clinical phenotype;clinical predictive model;Clinical Research;clinical risk;Clinical Trials;cohort;Data;Development;Diabetes Mellitus;diabetes mellitus genetics;Diabetes prevention;diabetes prevention program;diabetes risk;Disease;Disease Progression;effective therapy;Endocrinology;experience;Faculty;fasting glucose;fasting plasma glucose;follow-up;Foundations;functional genomics;Future;Genetic;Genetic Determinism;Genetic study;genomic locus;Glycosylated hemoglobin A;Goals;Heterogeneity;high risk;high risk population;Hospitals;Human;impaired glucose tolerance;Impairment;Incidence;Individual;Individual Differences;insight;Insulin Resistance;interest;Intervention;Israel;laboratory experience;Lecithin;Life Style;Lipids;Mass Spectrum Analysis;Master of Public Health;Measurement;Measures;Medical center;member;Mendelian randomization;Mentors;Metabolic Pathway;metabolomics;Metformin;Modeling;Molecular;Molecular Profiling;multiple omics;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;novel strategies;Participant;Pathway interactions;Patients;pharmacologic;Pharmacotherapy;Phenotype;Phospholipids;Physicians;Pilot Projects;Plasma;Population;population based;Prediabetes syndrome;Prediction of Response to Therapy;predictive marker;predictive modeling;Prevalence;prevent;Prevention;preventive intervention;Preventive treatment;prospective;Prospective, cohort study;Randomized;randomized, controlled study;Randomized, Controlled Trials;recruit;Research;Research Design;response;Risk;Risk Factors;Sampling;Scientist;skills;small molecule;Statistical Models;Subgroup;symposium;Testing;Training;Training Programs;trait;Translational Research;treatment choice;treatment effect;treatment strategy;trial comparing;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Phosphatidylcholine and cholesterol ester biomarkers of type 2 diabetes and preventive treatment effects


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Neurodegenerative;Substance Misuse

PHR: PROJECT NARRATIVE Substance abuse and HIV infection are highly prevalent, commonly co-occur, and have adverse effects on brain structure and function, but too few scientists are properly trained to study these important areas. The “Training on Addictions in Interdisciplinary NeuroAIDS (TRAIN)” program has been highly successful in its first two cycles in recruiting and preparing remarkably productive and culturally diverse pre- and post-doctoral scholars to conduct cutting edge research in this field. In seeking a second renewal of TRAIN we propose building on this success in preparing future leaders, with enhanced emphases on the biologic mechanisms by which HIV and substance use affect the CNS, as well as other factors that may improve or worsen these problems.

PI_NAMEs: IUDICELLO, JENNIFER E;MOORE, DAVID J (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;neuroAIDS;Research;Training

PROJECT_TITLE: Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Child Abuse and Neglect Research;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative In this proposal we build on a unique randomized controlled trial of foster care as an alternative for institutional care based in Bucharest, Romania. This valuable sample of children will be studied when participants are 22 years of age when we will examine the long-term consequences of early psychosocial deprivation and early intervention on cardiometabolic risk factors and health behaviors at the start of adulthood. This project will contribute significantly to our understanding of ways in which children exposed to early psychosocial deprivation are affected by their experiences and will directly inform policies and clinical practices.

PI_NAMEs: SLOPEN, NATALIE  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Acceleration;Address;Adolescence;Adult;adverse childhood events;Affect;Age;Age Years;Alcohol consumption;American Heart Association;Attention;Attenuated;Biological;Biological Factors;Biological Markers;Blood Pressure;Body Size;Brain;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cardiovascular risk factor;caregiving;Caring;Cell Aging;Child;Child Abuse and Neglect;Child Rearing;Childhood;clinical examination;clinical practice;Data;deprivation;design;Diastolic blood pressure;Diet;Disease Outcome;Early Intervention;emerging adult;experience;Exposure to;Fatty acid glycerol esters;follow-up;foster care;Foundations;Glucose;Health;health assessment;Health behavior;Human;Human Development;hypothalamic-pituitary-adrenal axis;Individual;Individual Differences;Infant;Inflammatory;innovation;Institution;Institutionalization;Intervention;Laboratories;Length;Life;Life Cycle Stages;Lipids;Long-Term Effects;Measurement;Metabolic;Methods;National Heart, Lung, and Blood Institute;neglect;Outcome;Participant;Patient Self-Report;Personal Satisfaction;Physical activity;physical conditioning;Physiological;Policies;prospective;Psychopathology;Psychosocial Deprivation;Randomized;Randomized, Controlled Trials;Recording of previous events;Research;response;Risk;Risk Behaviors;Risk Factors;Risk Marker;Role;Romania;Sampling;Serum;Shapes;Sleep;social;social factors;Stress;stress reactivity;Stressful Event;Structure;Sympathetic Nervous System;telomere;telomere loss;Telomere Shortening;Testing;Time;Tobacco use;Toddler;treatment as usual;trial comparing;trial design;Work;young adult

PROJECT_TITLE: The Effects of Early Psychosocial Deprivation on Cardiometabolic Risk in Early Adulthood

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: This research is relevant to public health because language processing skills are essential to successful functioning in everyday life, and the domain of language undergoes significant change during childhood and adolescence. Atypical language production is a symptom of developmental disorders such as stuttering, cluttering, and speech delay, and thus understanding the unfolding of language production skills is important for understanding these points of vulnerability in the language system as well as for identifying and intervening with these disorders. The project is relevant to the mission of advancing our knowledge of how two core cognitive systems, language and vision, function, interact, and emerge over the course of human development.

PI_NAMEs: FERREIRA, FERNANDA  (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Address;Adolescence;Adult;animation;Articulation;Attention;attentional control;Benchmarking;Canis familiaris;Characteristics;Child;Childhood;Clutterings;Cognitive;cognitive system;Complex;computerized tools;Critical Thinking;Cues;design;Development;developmental disease;Disease;Environment;Event;extrastriate visual cortex;Eye;Eye Movements;Face;Felis catus;Head Start Program;Human Development;Image;innovation;Knowledge;Language;language processing;Lead;Left;Life;Linguistics;Link;Location;Measures;Methods;Mission;Process;Production;Property;Psycholinguistics;Public Health;Research;Research Personnel;sample fixation;Semantics;skills;Speech;Speech Delay;Stuttering;Symptoms;System;Techniques;Testing;theories;tool;Vision;Visual;visual cognition;Visual Fields;Visual System

PROJECT_TITLE: Multi-Utterance Language Production