NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Distinguishing recurrent tumor from treatment effect following therapy remains a major clinical challenge in neuro-oncology. We will assess the potential of quantitative CEST imaging methodologies and develop an automated, deep-learning framework for post-treatment surveillance and biopsy guidance. If successful, the implications for the clinical management of patients with brain tumors and for the robust evaluation of the efficacy of experimental therapeutics are enormous.

PI_NAMEs: JIANG, SHANSHAN  (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: Adult;Aftercare;Amides;Angiogenesis Inhibitors;bevacizumab;Biopsy;Biopsy Specimen;Brain Neoplasms;Caring;Chemicals;chemotherapy;Clinical;Clinical Management;Clinical Pathways;clinical practice;Clinical Trials;Data;deep learning;deep learning algorithm;diagnosis standard;Diagnostic;Disease Progression;Early identification;efficacy evaluation;Excision;FDA approved;Glioblastoma;Goals;Guidelines;Human;Image;Imaging Device;imaging modality;improved;in vivo;Investigational Therapies;Local Therapy;Localized Malignant Neoplasm;Magnetic Resonance Imaging;Malignant Glioma;Malignant Neoplasms;Maps;Methodology;Methods;Molecular;neuro-oncology;neuroimaging;novel diagnostics;novel therapeutics;Operative Surgical Procedures;Output;Pathologic;Pathology;Patients;Positioning Attribute;predicting response;Primary Brain Neoplasms;Proteins;Protocols documentation;Protons;Quality of life;Radiation therapy;radiomics;recruit;Recurrence;Recurrent tumor;Repeat Surgery;response;Signal Transduction;Surrogate Markers;Techniques;temozolomide;Testing;Tissue Sample;treatment effect;treatment planning;Treatment Protocols;treatment response;tumor;tumor diagnosis;tumor heterogeneity

PROJECT_TITLE: Quantitative CEST MRI for GBM Early Response Prediction and Biopsy Guidance

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative We propose to determine the role of sensory-evoked activity in immature adult-born olfactory sensory neurons in their survival and integration in both the healthy and the regenerating adult olfactory system. This will advance our fundamental understanding of the contribution of newborn neurons to olfactory processing and regeneration. Furthermore, our findings may suggest strategies to promote the survival and integration of transplanted stem cell-derived neurons to repair damaged brain areas.

PI_NAMEs: CHEETHAM, CLAIRE ELIZABETH JANE (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Ablation;Adult;Affect;Area;Axon;Behavior;Biological Assay;Brain;Brain Injuries;Calcium;Chemicals;Data;Detection;Development;Effectiveness;Electron Microscopy;epithelial stem cell;Exhibits;Functional Imaging;Functional Regeneration;Genetic;Goals;Image;Immunohistochemistry;in vivo;innovation;insight;Life;Location;Mammals;Maps;Mediating;Modeling;Mus;Natural regeneration;Nervous System Disorder;neural circuit;Neurodegenerative Disorders;neurogenesis;neuron development;neuronal survival;Neurons;Newborn Infant;newborn neuron;Odorant Receptors;Odors;olfactory bulb;Olfactory Epithelium;olfactory marker protein;Olfactory Pathways;olfactory sensory neurons;optogenetics;Phase;Play;Population;Presynaptic Terminals;protein expression;Publishing;receptor expression;repaired;Research;Role;Sensory;sensory input;Signal Transduction;Stem Cell Development;stem cell population;stem cell therapy;Stem cell transplant;stem cells;structural imaging;Synapses;synaptogenesis;Testing;Time;Transcript;two-photon;Work

PROJECT_TITLE: Functional integration of newborn olfactory sensory neurons in the healthy and regenerating olfactory system

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research

ORG_CITY: ANN ARBOR

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE This proposed research will examine how major life transitions contribute to suicide risk over the life span. It will use two ongoing, longitudinal studies (the Americans Changing Lives and the Health and Retirement Study cohorts) and a comprehensive registry of suicide deaths (the National Violent Death Reporting System) to examine individual and contextual moderators of suicide risk over the life span.

PI_NAMEs: MEZUK, BRIANA  (contact);ZIVIN, KARA

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: access restrictions;Adult;Age;Aging;American;Area;Bereavement;Cause of Death;Cessation of life;Characteristics;cohort;Cohort Studies;Community Surveys;comorbidity;Complex;contextual factors;Data;data access;Data Science;Data Set;depressive symptoms;Diagnosis;Distal;Empirical Research;Ethnic Origin;Event;Feeling hopeless;Feeling suicidal;Foreclosure;Frequencies;Functional impairment;Gender;Geography;Goals;Health;Health and Retirement Study;health care availability;Housing;indexing;Individual;innovation;Intervention;Job loss;Life;Life Cycle Stages;life span;Link;Longitudinal cohort;Longitudinal Studies;Marriage;Measures;Medical;Mental Health;Modeling;modifiable risk;Neighborhoods;novel;Occupations;Pathway interactions;Pregnancy;Prevention;Prevention strategy;preventive intervention;protective factors;Public Health;Race;Recording of previous events;Registries;Reporting;Research;residence;residential segregation;Retirement;Risk Behaviors;Risk Factors;Schools;secondary analysis;Severities;sex;Shapes;Shock;social;social capital;social relationships;Socioeconomic Status;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;suicide mortality;Suicide prevention;Surveys;System;Techniques;Text;theories;Time;Violence;Work

PROJECT_TITLE: Aging, Major Life Transitions, and Suicide Risk

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: BIOCHEMISTRY

PHR: PUBLIC HEALTH RELEVANCE: The cells used for reproduction (germ cells) have the unusual property of being able to recreate an entire organism at fertilization. How this potential is creatd and preserved is not known. Our proposal investigates this question in the round worm C. elegans where it is possible to obtain large quantities of germ cells and where we have developed tools to edit the genome.

PI_NAMEs: SEYDOUX, GERALDINE CATHERINE JOELLE (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Affect;Animals;arm;base;Binding Proteins;Biochemical;Caenorhabditis elegans;Cell Differentiation process;Cell Proliferation;Cell Survival;Cells;Characteristics;Chromatin;chromatin modification;Complex;CRISPR/Cas technology;Cytoplasmic Granules;Development;Developmental Biology;Disease;Embryonic Development;Family;Fertilization;Funding;Gene Deletion;Gene Expression;Gene Expression Profile;gene network;Gene Silencing;Genes;Genetic;genetic analysis;Genetic Transcription;Genome;genome editing;genome-wide;Germ;Germ Cells;Germ Lines;Goals;Homologous Gene;innovation;interest;Lobular Neoplasia;Location;member;Methods;Molecular;mutant;Mutate;nano;next generation;Oocytes;Open Reading Frames;Organelles;Organism;Pattern;Phenotype;Play;Polycomb;posttranscriptional;premature;preservation;prevent;Process;programs;Property;protein expression;protein function;Proteins;public health relevance;rapid technique;Regulation;repaired;Reproduction;RNA;RNA-Binding Proteins;Role;scaffold;Scaffolding Protein;Shapes;Somatic Cell;Specific qualifier value;Structure of primordial sex cell;Surface;Time;tool;transcription factor;transcriptome;transcriptome sequencing;transmission process;whole genome;Work

PROJECT_TITLE: Regulation of Germ Cell Fate During Embryogenesis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: PATHOLOGY

PHR: We are proposing to develop small molecules that would block activity of the ASH1L histone methyltransferase in acute leukemias with high HOX expression. Ultimately, such compounds could be used as highly specific drugs for treatment of patients with aggressive forms of leukemia, which poorly respond to current therapies.

PI_NAMEs: GREMBECKA, JOLANTA  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Acute leukemia;acute leukemia cell;Acute Myelocytic Leukemia;Acute T Cell Leukemia;Affinity;antileukemic agent;ASH1L gene;Binding;Cells;Cessation of life;Characteristics;Chemicals;chemotherapy;Clinical Trials;cofactor;Complex;Data;Defect;design;Development;Diagnosis;Disease;Down-Regulation;Drug Kinetics;effectiveness evaluation;efficacy study;Exhibits;Failure;Gene Expression;Genes;Goals;Growth;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;hematopoietic stem cell differentiation;Hematopoietic stem cells;histone methyltransferase;Histones;Homeobox Genes;HOXA9 gene;improved;In Vitro;in vitro activity;in vivo;inhibitor;innovation;knock-down;Lead;lead candidate;leukemia;Leukemic Cell;leukemogenesis;loss of function mutation;Lysine;Malignant Neoplasms;MEIS1 gene;Metabolic;Methylation;MicroRNAs;Mixed-Lineage Leukemia;MLL gene;Modeling;mouse model;Mus;Mutation;nanomolar;novel;novel therapeutic intervention;novel therapeutics;Outcome;Outcome Study;overexpression;patient derived xenograft model;Patients;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacotherapy;Play;pre-clinical;Prognosis;Proliferating;Property;Proteins;Refractory Disease;Regulation;Reporting;Research;Role;Sampling;screening;SET Domain;small molecule;small molecule inhibitor;Solubility;Specificity;Structure;Survival Rate;T-Cell Development;targeted agent;Therapeutic;Therapeutic Agents;tool;Toxic effect;treatment strategy;United States;Up-Regulation;Work

PROJECT_TITLE: Development of ASH1L inhibitors for acute leukemia

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: MADISON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Our knowledge of heart regeneration is increasing, yet our understanding of which genes are key drivers and how regeneration signals control these genes are incompletely defined. We propose to characterize how cardiac injury induces the expression of paracrine factors that facilitate heart regeneration. Our results will have profound implications for understanding the heart regenerative process and developing innovative strategies to promote heart regeneration in mammals.

PI_NAMEs: KANG, JUNSU  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Adult;Automobile Driving;Bar Codes;Biological Assay;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;Cells;Computer Analysis;Cues;cytokine;Data;Development;Elements;Endocardium;Enhancers;Epicardium;epigenomics;eye regeneration;Fishes;gain of function;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;genetic approach;Genetic Transcription;Genome;Goals;Heart;heart damage;Heart failure;Heart Injuries;in vivo;injured;Injury;innovation;insight;Interleukins;Knock-in;Knowledge;Leptin;Link;loss of function;Mammals;MAP2K1 gene;Mediating;Modeling;Morbidity - disease rate;mortality;Mus;mutant;Natural regeneration;overexpression;paracrine;Pathway interactions;pharmacologic;Process;programs;Proliferating;Reactive Oxygen Species;regenerative;Regenerative capacity;Regenerative research;Regenerative response;Regulatory Element;Reporter;Reporter Genes;Reporting;Repression;response to injury;Role;Signal Transduction;spatiotemporal;System;Testing;Therapeutic;tool;transcriptome;Transgenic Organisms;Zebrafish

PROJECT_TITLE: Dissecting injury-responsive gene expression during zebrafish heart regeneration

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Exploratory animal research in stroke therapy development has not been predictive of clinical success. There are concerns over the design and conduct of pre-clinical studies, their reproducibility and generalizability. This proposal aims to help establish and contribute to a preclinical trial platform in acute ischemic stroke to overcome the translational roadblock.

PI_NAMEs: AYATA, CENK  (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Acute;acute stroke;Advocate;analysis pipeline;animal data;Animal Experimentation;Animal Model;Animals;automated analysis;Blinded;blood-brain barrier disruption;central database;Cerebral Ischemia;cerebroprotection;Charge;Chronic;Clinical;clinical candidate;clinical predictors;Clinical Trials;clinically relevant;Common Data Element;Complement;Data;design;diet-induced obesity;Edema;Ensure;Event;experience;Filament;follow-up;functional outcomes;Hemorrhage;high standard;Histologic;Human Resources;Hyperglycemic Mice;Image;Imaging Device;Inbred SHR Rats;indexing;innovation;Intervention;Ischemic Stroke;Laboratories;Lead;Magnetic Resonance Imaging;Manuscripts;Middle Cerebral Artery Occlusion;Modeling;molecular marker;mortality;Mus;National Institute of Neurological Disorders and Stroke;Neurocognitive;Neurologic;Neurological outcome;Obese Mice;optical imaging;Outcome Assessment;pandemic disease;Peer Review;Physiological;pre-clinical;pre-clinical assessment;preclinical study;Preclinical Testing;preclinical trial;prospective;Protocols documentation;Publishing;Randomized;Rattus;recruit;Reperfusion Therapy;Reproducibility;Research;resilience;Resources;response;Rest;Rodent;Safety;Scientist;Stroke;stroke intervention;stroke therapy;Structure;success;Testing;Therapeutic;therapy development;Tissues;tool;tractography;treatment effect;vasogenic edema;Video Recording;Weather;Wild Type Mouse;Work

PROJECT_TITLE: Stroke Preclicinal Assessment Network


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Mitochondria are important in providing energy for the contracting myocyte, but dysfunctional mitochondria can be harmful to the cell. This project will provide important new insights into the mechanisms of mitochondrial clearance in the myocardium and how defects in this process contribute to cardiovascular disease.

PI_NAMEs: GUSTAFSSON, ASA B. (contact)

PROJECT_TERMS: angiogenesis;Autophagocytosis;Autophagosome;Cardiac;Cardiovascular Diseases;Cardiovascular system;Cell membrane;Cell secretion;Cells;Cessation of life;Compensation;Complex;Contracts;Data;Defect;Defense Mechanisms;Degradation Pathway;Development;diagnostic biomarker;Disease;Docking;Early Endosome;Endosomes;Endothelial Cells;Ensure;exosome;extracellular vesicles;Fibroblasts;Functional disorder;Goals;Heart;Homeostasis;Impairment;In Vitro;in vivo;Inflammation;insight;knock-down;Label;late endosome;Lysosomes;Macrophage;Mediating;Mitochondria;Molecular;Mus;Muscle Cells;Myocardial Infarction;Myocardium;Myofibroblast;new therapeutic target;novel;Organelles;Oxidative Phosphorylation;Parkin;Pathway interactions;Plasma;Play;postmitotic;prevent;Process;programs;Proteomics;Quality Control;rab GTP-Binding Proteins;Research;Role;Route;Stress;System;Testing;trafficking;ubiquitin-protein ligase;Ubiquitination;uptake;Vesicle;Western Blotting

PROJECT_TITLE: Secretion of mitochondria as a cellular quality control mechanism

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE New evidence indicates that nuclear pore complexes, the channels that connect the nucleus and the cytoplasm, are important regulators of immune cell function. We recently discovered that the nucleoporin Nup210 regulates T cell survival and activation by modulating TCR-mediated gene expression. The goal of this research project is to decipher how Nup210 regulates gene expression and the transmission of T cell receptor signals.

PI_NAMEs: DANGELO, MAXIMILIANO A (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Activated Lymphocyte;Active Sites;adaptive immune response;Adaptive Immune System;Adaptor Signaling Protein;Amino Acids;Antibody Formation;Autoimmune Diseases;B-Lymphocytes;Biological Response Modifiers;C-terminal;caveolin-2;Caveolins;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell membrane;Cell Nucleus;Cell Physiology;Cell Survival;Cells;chronic infection;Communication;Cytoplasm;Data;Development;Dimerization;Ensure;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Immune;Immune response;Immune system;Immunity;Immunotherapy;Infection;Inflammation;insight;Insulin;Integral Membrane Protein;LCP2 gene;Ligation;Macrophage;Malignant Neoplasms;Mammalian Cell;Mediating;Molecular;novel;Nuclear;Nuclear Envelope;nuclear factors of activated T-cells;Nuclear Pore;Nuclear Pore Complex;Nuclear Pore Complex Proteins;nucleocytoplasmic transport;pathogen;Pathology;Pathway interactions;Phosphorylation;Play;Process;Proliferating;Proteins;RAN GTPase Activating Protein 1;Receptor Activation;Receptor Signaling;recruit;Regulation;Research Project Grants;response;Role;scaffold;Signal Transduction;STAT3 gene;Surface;T cell regulation;T cell therapy;T-Cell Activation;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Transactivation;transcription factor;Transcriptional Activation;transgene expression;transmission process;tumor growth;Work

PROJECT_TITLE: Characterizing the nuclear pore complex-T cell receptor connection

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Liver Disease;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Metastatic disease remains the primary cause of morbidity and mortality in cancer with little improvement in outcomes seen over the past decade. In this proposal, we investigate (i) mechanisms regulating the formation, (ii) the reversibility, and (iii) therapeutic implications of a niche environment in the liver that is supportive of cancer metastasis and growth. The proposed studies will incorporate clinically-relevant mouse models of cancer to inform development of novel strategies to prevent and treat cancer metastasis.

PI_NAMEs: BEATTY, GREGORY L (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Acute-Phase Proteins;Address;Agonist;Amyloid Proteins;Biology;cancer cell;Cancer Cell Growth;Cancer Model;cancer site;carcinogenesis;CD47 gene;Cell Proliferation;Cells;chemotherapy;Clinical;clinically relevant;Cytotoxic Chemotherapy;Deposition;design;Development;Disease;Elements;Environment;Equilibrium;Extracellular Matrix;Extracellular Matrix Proteins;Genetic;Goals;Growth;Hepatic Stellate Cell;Hepatocyte;human disease;Immunologics;improved;Interleukin-6;KPC model;KRASG12D;Kupffer Cells;Liver;Macrophage;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mechanics;Metabolic;Metastatic Neoplasm to the Liver;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myelogenous;Myeloid Cells;Nature;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Neutrophil Infiltration;Non-Malignant;novel;novel strategies;novel therapeutics;Outcome;Pancreas;pancreatic ductal adenocarcinoma model;Pliability;prevent;Primary Neoplasm;Process;Property;Risk Reduction;Role;Serum;Shapes;Signal Pathway;Signal Transduction;Soil;standard of care;STAT3 gene;Stromal Cells;Testing;Therapeutic;therapeutic target;therapy design/development;TNFRSF5 gene;tool;Treatment Efficacy;Tropism;tumor;Variant;Work

PROJECT_TITLE: Mechanisms and therapeutic targets of cancer metastasis

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Climate-Related Exposures and Conditions;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project narrative  Low-cost air-pollution networks, while becoming increasingly prevalent to ﬁll the knowledge-gaps left by sparse regulatory monitoring, introduce a series of novel features like need for co-location calibration to elim- inate noise, spatio-temporally correlated massive datasets, and repeated measures on exposures. Statistical methodology for more traditional air-pollution data collection schemes are not optimized to properly exploit the noisy, high-throughput, and spatio-temporally dependent low-cost data in scientiﬁc studies. We propose new statistical methods that will allow use of the low-cost data to answer new and interesting scientiﬁc questions like studying intra-urban variation in exposure using more detailed maps, improving personal exposure assessment, and using distributions (repeated measures) of exposures in health association studies.

PI_NAMEs: DATTA, ABHIRUP  (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Accounting;Address;Adopted;Affect;Air;Air Pollution;Atmosphere;Baltimore;Calibration;Categories;Computer software;cooking;cost;cost effective;Data;Data Collection;data reduction;Data Set;density;Dependence;Frequencies;Geography;Goals;Health;improved;indexing;Individual;innovation;insight;instrument;Knowledge;Least-Squares Analysis;Left;Linear Models;machine learning method;Maps;Measures;method development;Methodology;Methods;Modeling;Monitor;Noise;novel;open source;Outcome;pollutant;predictive modeling;random forest;Research;Resolution;Risk;Role;Sampling;Scheme;Scientist;sensor;Series;Site;Smoking;spatiotemporal;Statistical Methods;Techniques;Technology;Time;time use;training data;Update;uptake;user friendly software;Variant;wearable device;Work

PROJECT_TITLE: Statistical methods for air-pollution studies using low-cost monitors

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: Defects in mechanosensation lead to a variety of neurological diseases such as hearing loss and neuropathic pain that affect over a billion people worldwide. The proposed work will facilitate our understanding of mechanosensory transduction in humans and how its defects lead to diseases.

PI_NAMEs: XU, SHAWN  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Affect;Animal Behavior;Behavior;Behavioral;behavioral response;Biological Models;Biology;blood pressure control;blood pressure regulation;bone;Caenorhabditis elegans;Calcium;candidate identification;cell type;Cells;Data;Defect;Development;Disease;Drosophila acetylcholine receptor alpha-subunit;Electrophysiology (science);Environment;epithelial Na+ channel;Esthesia;Eye;Family;Force of Gravity;Frequencies;Functional Imaging;Generations;Genes;Genetic;Genetic Models;Genetic Screening;Goals;Head;Hearing;hearing impairment;Human;insight;interdisciplinary approach;Kidney;Lead;Light;Mammals;mechanical force;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Modality;Modeling;Molecular;Molecular Genetics;Muscle;mutant;Mutate;Mutation;Nervous System Disorder;neural;neuromechanism;Neurons;novel;Odors;Organ;Organism;Output;painful neuropathy;Persons;Piezo ion channels;Play;Prevalence;Proprioception;Reaction;Research;response;Role;Sensory;Sensory Receptors;sensory system;sound;Stretching;Study models;System;Testing;Time;tool;Touch sensation;Work

PROJECT_TITLE: Neural and genetic mechanisms underlying mechanosensation in C. elegans

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project narrative Injection is an increasingly common route of administration for opioids and other drugs in the U.S. and increases risk for infectious diseases such as HIV and hepatitis C virus. However, there are no state-level estimates of how many people inject drugs or their characteristics, making infectious disease prevention programs difficult to plan, implement, and monitor. In this project, we will use big data to create estimates of the size of the population injecting drugs in New York, and these estimates will serve as a model for other states aiming to address the infectious disease consequences of the opioid crisis.

PI_NAMEs: BRADLEY, HEATHER  (contact);ROSENBERG, ELI SAMUEL

PROGRAM_OFFICER_NAME: DEPADILLA, LARA MIREILLE

PROJECT_TERMS: Accident and Emergency department;Accounting;Achievement;Acquired Immunodeficiency Syndrome;Acute Hepatitis C;Address;Admission activity;Age;Bayesian Modeling;Behavior;Big Data;Big Data to Knowledge;Blood;burden of illness;Canada;Characteristics;Collaborations;Communicable Diseases;County;Data;Data Set;data visualization;Dependence;Development;Diagnosis;Disease;disorder risk;drug use behavior;Electronics;Epidemic;Epidemiologist;Epidemiology;Estonia;experience;Goals;Health;Health Services;Health Services Accessibility;Hepatitis C;Hepatitis C virus;Heterogeneity;high risk;HIV Infections;HIV/HCV;Hospital Records;Household;housing instability;Imprisonment;improved;Individual;Infection;infection burden;Infective endocarditis;Injecting drug user;injection drug use;Injections;innovation;Inpatients;Intervention;Joints;Leadership;Link;male;Measures;Methodology;Methods;Modeling;Monitor;Needle-Exchange Programs;New York;Opioid;opioid epidemic;opioid use disorder;Persons;Pharmaceutical Preparations;Pharmacotherapy;Politics;Population;Population Sizes;Prevention program;prevention service;preventive intervention;Probability;Process;Public Health;remediation;Reporting;research study;Resources;response;Risk;Route;Services;sex;Standardization;Stigmatization;surveillance data;Surveys;System;treatment program;United States National Institutes of Health;Work

PROJECT_TITLE: Estimating the population size of persons who inject drugs in New York

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(55)]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Infectious Diseases;Malaria;Neurosciences;Pediatric;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PUBLIC HEALTH RELEVANCE Identification of the key central nervous system and systemic factors that together contribute to neurodevelopmental impairment in cerebral malaria or severe malarial anemia could lead to interventions that prevent or decrease brain injury and the loss of developmental potential in hundreds of thousands of children in malaria endemic areas of Africa.

PI_NAMEs: JOHN, CHANDY C. (contact);OPOKA, ROBERT

PROGRAM_OFFICER_NAME: HARDY, KRISTINA KOREN

PROJECT_TERMS: 4 year old;Acute Renal Failure with Renal Papillary Necrosis;Affect;Africa;Age;Area;Atrophic;Behavior;Biology;Blood flow;Blood Vessels;Brain;Brain Injuries;brain magnetic resonance imaging;Central Nervous System;Central Nervous System Diseases;Cephalic;cerebral atrophy;Cerebral Malaria;Cerebrovascular Circulation;Child;Childhood;Clinical;Cognition;cohort;Communities;Control Groups;cytokine;Data;design;Development;Disease;Electroencephalography;Electrophysiology (science);Endothelium;Enrollment;Evaluation;Event-Related Potentials;follow-up;Functional disorder;global health;Goals;Immune response;Impairment;Indiana;Inflammatory;inflammatory marker;Intervention;Investments;Kenya;machine learning model;Magnetic Resonance Imaging;Malaria;malarial anemia;Malawi;Mediating;Mediation;Multifocal Lesion;neurodevelopment;Neurodevelopmental Impairment;Neurological observations;neuroregulation;neurotransmission;novel;Obstruction;Pathway interactions;Pattern;Plasma;point of care;point of care testing;prevent;Process;public health relevance;Qualifying;Recovery;Reproducibility;Research;response;Risk;Risk Factors;Statistical Models;System;Testing;Training;Transcranial Doppler Ultrasonography;Traumatic Brain Injury;UCHL1 gene;Uganda;Universities;X-Ray Computed Tomography

PROJECT_TITLE: Severe Malaria And Risk to The Brain (SMART Brain)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-T (55)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Lymphatic Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE/RELEVANCE Aging-induced changes in the structure and function of lymph nodes result in lymph node atrophy, which is important because lymph nodes play a key role in orchestrating immune responses. The molecular mechanisms driving these changes in aging lymph nodes are poorly understood, but reduced activation of NFκB signaling in lymph node lymphatic endothelial cells may provide a rationale. Therefore, the information gained from the proposed study may help uncover therapeutic strategies that may improve immune function in the elderly and reduce their risk for autoimmune disorders, life-threatening infections, and impaired response to vaccines and tumors.

PI_NAMEs: KATARU, RAGHU PRASAD (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: adaptive immune response;Adult;Affect;age effect;aged;Aging;aging related;aging reversal;Animals;Antigen Presentation;Antigen-Presenting Cells;Antigens;Atrophic;Autoantigens;Autoimmune Diseases;Automobile Driving;B-Cell Activation;B-Lymphocytes;Bacterial Antigens;Bacterial Infections;Biological Models;Body System;Bone Marrow;cell motility;Cellularity;chemokine;conditional knockout;cytokine;Development;draining lymph node;Elderly;Elderly man;Elderly woman;Embryo;Embryonic Development;Enhancers;experimental study;Family;Fibrosis;fluid flow;Future;Gene Expression;Goals;Harvest;Helper-Inducer T-Lymphocyte;Hematopoietic;Heterogeneity;Histologic;Homeostasis;Hypertrophy;IL7 gene;Immune;immune function;Immune response;immunosenescence;Impairment;improved;In Vitro;Individual;Infection;Inflammation;Inflammatory;Innate Immune Response;innovation;Intercellular Fluid;interstitial;Intestines;Knowledge;Life;Light;Lipomatosis;lymph flow;lymph nodes;Lymphatic;lymphatic circulation;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic function;Lymphatic System;lymphatic vessel;Lymphocyte;Lymphoid Tissue;Macrophage;Maintenance;mature animal;member;Meninges;Mesentery;middle age;Molecular;Morphology;Mus;NF-kappa B;Nuclear;Nuclear Translocation;old mice;older adult;Organogenesis;p65;Pathway interactions;Peripheral;Phenocopy;Phenotype;Play;Population;prevent;Production;recruit;Regulatory Pathway;Research Design;response;Risk;Risk Factors;Role;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Sinus;Skin;Structure;T-Lymphocyte;Testing;Therapeutic;three dimensional cell culture;three-dimensional modeling;Thymus Gland;Tissues;transcription factor;transcriptome;Transgenic Mice;Transgenic Organisms;Transplantation;tumor;Vaccines;Virus Diseases;young adult

PROJECT_TITLE: Role of lymphatic endothelial cell NFkB signaling in adult lymph node homeostasis

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Behavioral and Social Science;Genetics;Human Genome;Mental Health;Prevention;Suicide;Suicide Prevention;Violence Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Suicide results in >800,000 world deaths annually, and suicide rates in India, rising over the past five decades, now reflect the highest rates in the world. This proposal describes a cost-effective, large-scale collection of blood, brain, phenotypic, and psychological autopsy data in India from postmortem suicide cases and controls to increase the generalizability and impact of global genetic and epidemiological studies of suicide death. This unique data resource will stem from a close collaboration between academic suicide research laboratories in the United States and Delhi, India.

PI_NAMEs: BEHERA, CHITTARANJAN ;DOCHERTY, ANNA R. (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Admixture;Age;ancestry analysis;Area;Attention deficit hyperactivity disorder;Autopsy;Biological;biological research;Blood;Blood Banks;Blood specimen;Brain;brain tissue;case control;Cause of Death;Cessation of life;Clinical;clinical risk;cohort;Collaborations;Collection;Communities;Complex;cost effective;Country;Data;data resource;Databases;design;DNA;Ensure;Environmental Risk Factor;epidemiology study;Equity;Etiology;Funding;Future;Genes;Genetic;genetic analysis;genetic profiling;Genetic Research;Genetic Risk;genetic risk factor;Genetic study;genome wide association study;Genotype;girls;Healthcare Systems;Impulsivity;Income;India;Individual;Infrastructure;International;Laboratory Research;Libraries;Medical;Medical Records;men;Mental Health;Meta-Analysis;Methylation;Modeling;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;polygenic risk score;Population;population based;Population Study;preservation;Prevention;Program Sustainability;psychiatric genomics;psychogenetics;psychologic;Public Health;Publishing;Quality Control;Reporting;Research;Resources;Risk;Risk Factors;Role;Sampling;Science;selective prevention;sex;Smoking;social stigma;Societies;stem;suicidal;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide mortality;Suicide prevention;suicide rate;Time;Tissue Banks;Tissue Sample;Toxicology;Training;Translational Research;Underrepresented Populations;United States;Utah;Validation;Woman;working group

PROJECT_TITLE: Building Resources for the Diversification of Genetic Data on Suicide Death


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_DEPT: SURGERY

PHR: Project Narrative Severe alcoholic hepatitis (SAH), an acute presentation of alcoholic liver disease (ALD), carries an extremely high mortality rate and early liver transplantation (ELT) is the only life-saving option available for patients who are refractory to medical management. We have established the largest cohort of ELT recipients in the world and preliminary investigations have shown promising short-term outcomes for individuals who undergo ELT and given us considerable insight into the pathophysiology of ALD. The insight provided by the studies described in the projects that comprise our ALD research initiative will be integral for guiding the expansion of ELT and the ethical framework developed will help influence the creation of a national policy governing the practice.

PI_NAMEs: CAMERON, ANDREW M. (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Accounting;Acute;Adoption;Affect;Alcohol consumption;alcohol exposure;alcohol research;Alcoholic Hepatitis;Alcoholic Liver Diseases;Animal Model;Animals;Area;Autoantibodies;Behavioral;Biological;Biology;candidate selection;Caring;Clinical;cohort;collaborative approach;Communities;Complex;COVID-19 pandemic;Critical Illness;Death Rate;Development;Disadvantaged;Disease;Ensure;Equity;Ethical Analysis;Ethical Issues;Ethics;evidence base;experience;follow-up;Functional disorder;Goals;Guidelines;Heavy Drinking;Human;human disease;Immune system;Immunologics;improved;In Vitro;Individual;insight;interdisciplinary approach;Intervention;Investigation;Life;Liver;Liver Regeneration;liver transplantation;Medical;Mental disorders;Molecular;mortality;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;novel;organ allocation;Outcome;Pathology;Patient Selection;patient subsets;Patients;Pattern;Perception;pharmacologic;Phenotype;Policies;policy implication;post-transplant;prevent;preventable death;Prevention program;Process;Prognosis;programs;Proteomics;Public Opinion;recidivism;Refractory;Relapse;relapse prevention;Research;Resources;risk minimization;Role;Selection Criteria;service delivery;Severity of illness;sobriety;social health determinants;sound;stakeholder perspectives;Standardization;substance abuse treatment;success;Suspensions;Syndrome;Therapeutic;Time;Tissues;transplant centers;transplant model;Transplant Recipients;Transplantation;United States;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: Multidisciplinary approach to study of patients with Severe Alcoholic Hepatitis Undergoing Liver Transplantation

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 DD (60)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Organ Transplantation;Substance Misuse;Transplantation

PI_NAMEs: WARREN, DANIEL S (contact)

PROJECT_TERMS: Acute;alcohol effect;alcohol research;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Animals;Autoantigens;Behavior Therapy;Biological Markers;Budgets;Caring;Central Nervous System;Clinical;cohort;Collaborations;Communication;Communities;Death Rate;Disease;Ethics;expectation;experience;Functional disorder;Funding;Future;Goals;Grant;Immune;Individual;innovation;insight;Institutional Review Boards;interdisciplinary approach;Investigation;Leadership;Life;Liver;liver transplantation;Logistics;Manuscripts;Medical;Medicine;meetings;member;Mentors;mortality;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;next generation;novel;Operative Surgical Procedures;Outcome;outreach;Pathogenesis;Pathogenicity;Pathology;Patient Care;patient population;Patient Selection;Patients;Pharmacology;Policies;Positioning Attribute;post-transplant;Preparation;programs;Proteomics;Recovery;Refractory;regenerative;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Structure;symposium;Tissues;Training;Training Support;transplant model;Transplant Recipients;Universities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease;Organ Transplantation;Substance Misuse;Transplantation

PHR: In the United States, alcoholic liver disease is the second most common indication for liver transplant. This core resource will thus support the projects of this application related to the diagnosis and treatment of liver disease with high quality evaluation and collection of tissues.

PI_NAMEs: ANDERS, ROBERT A. (contact)

PROJECT_TERMS: Address;Alcohol abuse;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;animal tissue;Basic Science;biobank;Biological;Chicago;Chronic;Cities;Clinic;Clinical;Clinical Data;Collaborations;Collection;Colorado;Data;Databases;Diagnosis;Disease;Evaluation;Formalin;Fostering;Freezing;Funding;Graft Rejection;Harvest;Histologic;Human;human tissue;Illinois;Indiana;Institutional Review Boards;interdisciplinary approach;Kansas;Life;Link;Liquid substance;Liver;Liver diseases;liver transplantation;Medical;member;Minnesota;mortality;National Cancer Institute;National Institute on Alcohol Abuse and Alcoholism;Paraffin Embedding;Pathologic;Pathologist;Pathology;Patient Care;Patients;Practice Guidelines;programs;Recording of previous events;Research;Research Personnel;Resource Sharing;Resources;Rodent;Sampling;Services;Specimen;Supervision;Surgeon;System;Texas;Tissue Banks;Tissue Sample;Tissues;translational impact;Transplant Recipients;Transplantation;United States;Universities;Veronica;Work

PROJECT_TITLE: Pathology Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Disease;Organ Transplantation;Social Determinants of Health;Substance Misuse;Transplantation

PHR: Severe alcoholic hepatitis (SAH), an acute type of alcoholic liver disease, carries an extremely high mortality rate and early liver transplantation (ELT) is the only life-saving option available for patients who are refractory to medical management. Despite an increase in the number of centers performing ELT, access to this resource remains limited due to inhibitory social determinants of health (SDoH) that affect how patients progress through the referral, evaluation and transplant process. Understanding how (SDoH) affect ELT access and outcomes as well as assessment of public perception about ELT for SAH is vital for support and future treatment of these patients; therefore, the goals of this study are to establish how social determinants of health impact ELT as well as the continued development of an evidence-based ethical framework regarding ELT for SAH.

PROJECT_TERMS: access disparities;Accounting;Acute;Address;Admission activity;Affect;Alcohol consumption;Alcohol dependence;alcohol research;Alcoholic Hepatitis;Alcoholic Liver Diseases;Area;Bioethics;candidate selection;care outcomes;Caring;Cessation of life;Clinical;cohort;Communities;Consensus;Data;Death Rate;deprivation;Development;Diagnosis;disparity reduction;drinking;Ensure;Equity;Ethics;Evaluation;evidence base;experience;follow-up;Future;gaps in access;General Population;Geographic Locations;Geography;Goals;Grant;Health Professional;Health Service Area;hospital services;improved;Income;indexing;Individual;Inferior;Informed Consent;Infrastructure;Insurance;interdisciplinary approach;Intervention;Life;Literature;liver transplantation;Measures;Medical;mortality;multilevel analysis;National Institute on Alcohol Abuse and Alcoholism;Neighborhoods;news;Not Hispanic or Latino;novel;Outcome;Outcome Assessment;participant enrollment;Patient advocacy;Patient Care;patient population;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Perception;Phase;PhenX Toolkit;Pilot Projects;Policies;Population;Populations at Risk;post-transplant;Privatization;Process;Prospective cohort;Prospective, cohort study;Provider;Quality of Care;Reaction;Recommendation;Refractory;Relapse;Research;Resolution;Resources;response;Selection Criteria;sobriety;social health determinants;social media;sociodemographic factors;socioeconomic disadvantage;socioeconomics;Specialist;Substance Use Disorder;success;transplant centers;Transplant Recipients;Transplantation;United States;United States National Institutes of Health;Universities;Vulnerable Populations;Waiting Lists;Work

PROJECT_TITLE: Project 1-Cohort/Ethics Study of Patients with Severe Alcoholic Hepatitis undergoing Early Liver Transplantation


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease;Organ Transplantation;Prevention;Substance Misuse;Transplantation

PHR: PROJECT NARRATIVE Post-transplant addiction care for liver recipients who had severe alcohol-associated liver disease is necessary to prevent harmful returns to alcohol use. However, effective, easy-to-implement, and sustainable intervention strategies remain a critical knowledge gap. The proposed project—combining observational studies and an intervention trial—will systematically investigate early and long-term approaches to enhance liver transplant recipients’ engagement in alcohol treatment services and improve post-transplant outcomes.

PI_NAMEs: CHEN, PO-HUNG (VICTOR)  (contact)

PROJECT_TERMS: Abstinence;acamprosate;addiction;Adjuvant;Advocate;Affect;Age;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol intervention;alcohol relapse;alcohol research;alcohol risk;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Attention;Behavior Therapy;Biological Markers;brief intervention;Caring;Chronic;Clinic;Clinical;clinical care;Clinical Protocols;cohort;Cohort Studies;Combination Drug Therapy;Communication;Costs and Benefits;COVID-19 pandemic;Data;Diagnosis;Dissemination and Implementation;Early treatment;Enrollment;Equilibrium;Equity;evidence base;experience;Face;Fatigue;Funding;Goals;Graft Rejection;Harm Reduction;Hepatology;Home;hospital readmission;Hospitalization;Hospitals;improved;indexing;Individual;Institution;interdisciplinary approach;interest;Intervention;Intervention Trial;Interview;Knowledge;Liver;Liver diseases;liver transplantation;Medical;Methods;Modeling;mortality;motivational enhancement therapy;Naltrexone;Observational Study;Operative Surgical Procedures;Organ;Outcome;pandemic disease;Participant;Patient Participation;Patients;peer support;Pharmacotherapy;Phase;post-transplant;practice setting;prevent;programs;Provider;Psychiatrist;psychosocial;Randomized, Controlled Trials;Recommendation;Relapse;relapse risk;Reporting;Research;residence;Resources;Risk Factors;safety outcomes;Schedule;Shapes;Societies;Specialist;Surgical complication;survival outcome;System;Techniques;Technology Assessment;Time;Training;Transplant Recipients;Transplantation;treatment services;United States;Work

PROJECT_TITLE: Project 2-Optimization of Post-Transplant care via Biomarkers and Behavioral Interventions


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Autoimmune Disease;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Infectious Diseases;Liver Disease;Microbiome;Organ Transplantation;Substance Misuse;Transplantation

PI_NAMEs: ZHU, HENG  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;Acute;Adrenal Cortex Hormones;Alcohol abuse;Alcoholic Hepatitis;Alcoholic Liver Diseases;Animal Model;anti-microbial peptide;Antibodies;Antibody Formation;antibody-dependent cell cytotoxicity;Antigens;Autoantibodies;Autoantigens;Autoimmune;Bacteria;bacterial lysate;Bacteroidetes;Biological Assay;Cell Nucleus;Chronic;chronic alcohol ingestion;cohort;Complement;Complement 3d;complement C4d;Cross Reactions;cross reactivity;Cytoplasm;Cytosol;cytotoxicity;Death Rate;Deposition;Development;Disease;DNA;dysbiosis;Escherichia coli;Escherichia coli K12;Escherichia coli Proteins;Ethics;Etiology;Exhibits;fabrication;Focal Adhesions;Functional disorder;Funding;Fusobacteria;Goals;gut bacteria;gut microbiome;gut-liver axis;Hepatitis B Virus;Hepatitis C virus;Hepatocyte;HIV/HCV;Human;human model;Immune response;Immunoglobulin A;Immunoglobulin G;Immunoglobulins;Individual;Infection;Infiltration;Inflammation;insight;interdisciplinary approach;Intestinal permeability;Investigation;Leaky Gut;Life;Link;Literature;Liver;liver injury;liver transplantation;Medical;Molecular;mortality;Mucous body substance;Mycobacterium tuberculosis;new therapeutic target;nonalcoholic steatohepatitis;novel therapeutics;Outcome;pathogenic bacteria;Pathogenicity;Patients;Plasma Cells;Pneumonia;Policies;Predisposition;Prevention;problem drinker;Process;Production;Proteins;Proteobacteria;Proteome;pyrosequencing;Refractory;Research;Rest;Ribosomal RNA;Role;Serum;Stains;stool sample;success;Testing;Therapeutic Intervention;Tight Junctions;Tissues;Transplant Recipients;Virus Diseases

PROJECT_TITLE: Project 3-Characterizing the contribution of autoantibodies to liver damage in alcoholic hepatitis


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Organ Transplantation;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse;Transplantation

PI_NAMEs: SUN, ZHAOLI  (contact)

PROJECT_TERMS: Abstinence;Acute;alcohol abstinence;Alcohol abuse;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol relapse;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Allogenic;allograft rejection;Allograft Tolerance;Allografting;Animal Model;Animals;Behavior;Biological;Bone Marrow Stem Cell;Cells;Chronic;Clinical;Clinical Data;cohort;Complex;Death Rate;dietary control;drinking;Ethics;Functional disorder;Funding;Genes;Heritability;immunoregulation;Immunosuppression;improved;Individual;Infiltration;Injury;insight;interdisciplinary approach;Investigation;Knowledge;Leukocytes;Life;Liver;liver allograft;Liver diseases;Liver Regeneration;liver transplantation;Living Donors;Medical;Modeling;Natural Immunity;Natural regeneration;neutrophil;Neutrophil Infiltration;novel;Outcome;oxidative damage;Patients;peripheral blood;Phenotype;Play;Policies;prevent;Rattus;Refractory;Research;Respiratory Burst;Role;stem cells;symposium;Tacrolimus;Testing;Therapeutic immunosuppression;Time;transplant model;Transplant Recipients;Transplantation

PROJECT_TITLE: Project 4-Early Liver Transplantation for Severe Alcoholic Hepatitis: Animal Studies


ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE - OVERALL Alcohol consumption during pregnancy increases the risk of causing functional brain damage in the fetus that can lead to life-long adverse neurobehavioral consequences. Except in more severe cases, many children affected by prenatal alcohol exposure are difficult to identify, particularly early in life when interventional approaches may have the greatest positive impact. The New Mexico Alcohol Research Center’s objectives are to advance our understanding of how prenatal alcohol exposure causes functional brain damage and use this information to develop better procedures for the diagnosis and treatment of prenatal alcohol effects earlier in life.

PI_NAMEs: VALENZUELA, CARLOS FERNANDO (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Acceleration;Achievement;Address;Advisory Committees;Affect;alcohol behavior;alcohol consumption during pregnancy;alcohol research;Alcohols;Area;ARHGEF5 gene;Award;Behavioral;biobehavior;Biochemical;Biological Markers;Brain Injuries;Child;Cities;Clinical;clinical investigation;Clinical Investigator;Clinical Research;Collaborations;Communication;Community Outreach;data management;Development;Diagnosis;diagnostic biomarker;Education;effective intervention;efficacy evaluation;Ensure;Environment;Faculty;faculty mentor;fetal;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetus;Foundations;Goals;graduate student;Grant;Health Sciences;human subject;Individual;International;Intervention;Investigation;Knowledge;laboratory experience;Leadership;Life;meetings;Mentors;Methods;National Institute on Alcohol Abuse and Alcoholism;neurobehavioral;neurobiological mechanism;New Mexico;novel;offspring;Patients;Phase;Philosophy;Physiological;Pilot Projects;pre-clinical;pre-doctoral;prenatal;prenatal intervention;Procedures;Production;prognostic;programs;Recording of previous events;recruit;Research;Research Activity;Research Personnel;Research Support;Resources;Risk;Scientist;Series;symposium;synergism;tool;Training;Training Programs;translational scientist;undergraduate student;Universities;web page;Work

PROJECT_TITLE: C0-Overall:  Fetal Ethanol-induced behavior deficits: Mechanisms, diagnosis and Intervention


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

PROJECT_TERMS: Achievement;Administrative Coordination;Advisory Committees;alcohol behavior;alcohol research;Alcoholism;Applications Grants;Behavioral;Brain;Budgets;Center for Translational Science Activities;Clinical;Clinical Investigator;Clinical Research;Collaborations;college;Communication;Communities;Community Outreach;Development;Diagnosis;disability;effective intervention;Environment;Faculty;faculty mentor;fetal;Fetal Alcohol Spectrum Disorder;Future;Goals;Grant;Group Meetings;Health Sciences;Human Resources;Individual;Institution;Intervention;Knowledge;laboratory experience;Leadership;meetings;Methods;National Institute on Alcohol Abuse and Alcoholism;neurobiological mechanism;Neurosciences;operation;pediatric department;Pharmacy facility;Pilot Projects;pre-clinical;pre-clinical research;Preparation;Process;programs;Progress Reports;Psychology;Recording of previous events;Recovery;recruit;repaired;Research;Research Personnel;Research Project Grants;Research Training;Resource Allocation;Resources;Series;Societies;Substance abuse problem;Substance Addiction;symposium;synergism;System;Training;undergraduate student;Universities;web page;Work

PROJECT_TITLE: C1-Administrative Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse

PHR: Narrative The Scientific Core will facilitate the goals of the New Mexico Alcohol Research Center by supporting access to human subjects, consolidating and standardizing mouse prenatal and postnatal alcohol exposure procedures and colony management, and providing statistical support for all components of the center. Use of the Scientific Core will significantly decrease costs, prevent duplication of resources, and facilitate integration of results obtained across the center research components

PI_NAMEs: BRIGMAN, JONATHAN L (contact)

PROJECT_TERMS: alcohol behavior;Alcohol consumption;alcohol exposure;alcohol research;Animals;behavior test;Behavioral;Biometry;Blood alcohol level measurement;Brain;Characteristics;Child;Clinic;Clinical;Clinical Research;Communication;Communities;Computer software;Consultations;Consumption;cost;Data;Data Analyses;Development;Developmental Disabilities;Diagnosis;Diagnostic;drinking;Early Intervention;Ensure;Evaluation;Fees;fetal;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Future;Goals;Growth;Histologic;Human;human subject;Human Subject Research;Image Analysis;Institution;Intervention;intervention program;Liquid substance;Mescalero;Monitor;mouse model;Mus;Neonatal;New Mexico;novel;novel diagnostics;novel therapeutic intervention;offspring;outreach clinics;Participant;Patient Recruitments;Pattern;pediatric department;Phase;Pilot Projects;Play;Population;Population Heterogeneity;postnatal;pre-clinical;Pre-Clinical Model;prenatal;Preparation;prevent;Procedures;Production;pup;Recovery;recruit;repaired;Reproducibility of Results;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Role;Sampling Studies;Schools;Second Pregnancy Trimester;Services;Sex Distribution;Site;Slide;Source;Standardization;Study models;synergism;System;Third Pregnancy Trimester;Training;vapor;Zuni

PROJECT_TITLE: C2-Scientific Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

PHR: Narrative This project will use state-of-the-art neuroimaging tools combined with a computational model to examine the underlying mechanisms associated with cognitive and behavioral effects of prenatal alcohol exposure gaining insight from the other center projects. The long-term goal is to understand the neurophysiological underpinnings of cognitive deficits to guide treatment development for individuals affected by prenatal alcohol exposure. This study addresses the needs of individuals with fetal alcohol spectrum disorder and their families and advances the NIAAA Strategic Plan focused on understanding the underlying mechanisms associated with deficits from prenatal alcohol exposure.

PI_NAMEs: STEPHEN, JULIA MARIE (contact)

PROJECT_TERMS: 16 year old;Address;Adolescence;Adolescent;Adult;Affect;Age;alcohol behavior;Animal Model;Animals;Attention;Behavior;Behavioral;Binding;Biophysics;Brain;burden of illness;Chronic stress;Clinical;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive performance;cognitive task;Computer Models;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Distal;Environment;Equilibrium;experience;Exposure to;Family;fetal;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;flexibility;Goals;Grant;Human;human model;Impaired cognition;Impairment;improved;Individual;information processing;innovation;insight;Interneurons;Intervention;Knowledge;Link;Magnetic Resonance Imaging;Magnetoencephalography;Mammals;Measurable;Measures;model design;Modeling;multisensory;National Institute on Alcohol Abuse and Alcoholism;neocortical;neural;neuroimaging;neurophysiology;Outcome;Performance;Pharmacologic Substance;Population;pre-clinical;preclinical study;Prevalence;response;Rest;Rodent Model;Role;Sensory;sex;Short-Term Memory;societal costs;Strategic Planning;Stress;Stressful Event;Structure;Testing;therapy development;tool;Translations;United States;Visual;Visuospatial;Work

PROJECT_TITLE: C3-Neural oscillations in visual cognitive deficits


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

PHR: Project Narrative The proposed studies will contribute to public health by identifying functional, structural, and molecular targets for treating cognitive deficits associated with fetal alcohol spectrum disorders; the most common neurodevelopmental disease in the United States. These studies will determine the consequences of alcohol exposure during the rodent equivalent of human neonatal development on a key brain circuit that regulates working memory and decision making, and will provide new avenues for treating individuals with fetal alcohol spectrum disorder.

PI_NAMEs: LINSENBARDT, DAVID NATHANIEL (contact)

PROJECT_TERMS: Affect;alcohol behavior;alcohol consequences;alcohol effect;alcohol exposure;alcohol research;alcohol use disorder;Alcohols;Area;Behavior;Behavioral;Biochemical;Biological;Biological Assay;Biological Markers;Blood;Brain;Cognitive;cognitive ability;cognitive control;Cognitive deficits;cognitive function;Coupling;Cues;Decision Making;density;Development;Diagnosis;Disease;effective therapy;Electrodes;Electrophysiology (science);Executive Dysfunction;executive function;fetal;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;flexibility;Functional impairment;Genetic Transcription;Goals;Health;Histologic;Home;Human;Impairment;improved;in vivo;Individual;innovation;insight;Intervention;Lead;Learning;life span;Location;Measures;Medial;Medial Dorsal Nucleus;Mediating;Molecular Target;mouse model;Mus;myelination;National Institute on Alcohol Abuse and Alcoholism;neonatal human;neural;neurobiological mechanism;Neurocognitive Deficit;Neurodevelopmental Disorder;Neuroimmune;neuromechanism;Neurons;New Mexico;Noise;novel;Pathology;Performance;Phase;Pre-Clinical Model;Prefrontal Cortex;Pregnancy;prospective memory;Public Health;Reporting;Research;Rest;Rodent;Role;Sensory;Short-Term Memory;Signal Transduction;Silicon;Site;Strategic Planning;Structure;synergism;Testing;Thalamic structure;Time;touchscreen;transmission process;United States;Visuospatial;Wakefulness;white matter;Work

PROJECT_TITLE: C4-Effects on Corticothalamic function


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Immunization;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse;Vaccine Related

PHR: Project Narrative Emerging evidence from both preclinical and clinical studies support that the biological vulnerability to chronic central nervous system (CNS) dysfunction in FASD populations is driven by aberrant CNS-immune interactions rendering them particularly susceptible to developing cognitive disabilities during the period of adolescence, often manifesting after secondary challenges such as stress or immune challenges. While the underlying mechanism of adolescent cognitive deficits from prenatal alcohol exposure (PAE) is unknown, the proposed research will identify whether non-coding circular RNAs underlie sensitized CNS-inflammatory immune signaling pathways, potentially inclusive of TLR4-associated factors, from PAE that leads to cognitive deficits. Exploring these novel molecular targets in preclinical models along with leveraging clinical data from adolescent children with FASD, will provide a foundation to develop future therapeutic targets to treat adolescent cognitive deficits as well as identify biomarkers of adolescent cognitive dysfunction for early intervention to mitigate the impact PAE exerts on cognitive function.

PI_NAMEs: MILLIGAN, ERIN DAMITA (contact)

PROJECT_TERMS: Acute;Adolescence;Adolescent;Adult;Age;alcohol behavior;alcohol exposure;alcohol research;Amygdaloid structure;Anatomy;Animal Model;Animals;Anterior;Attention;Automobile Driving;Behavioral;Biological;biological adaptation to stress;Biological Markers;biomarker identification;Blood;Brain;Brain region;Central Nervous System;Central Nervous System Diseases;central sensitization;Child;Chronic;cingulate cortex;circular RNA;Clinical Data;Clinical Research;Cognitive;Cognitive deficits;cognitive disability;cognitive function;cognitive reappraisal;cognitive task;cognitive testing;Complement;Data;Development;Diagnosis;disability;Early Intervention;emerging adult;Evaluation;Exposure to;Female;fetal;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Foundations;Functional disorder;Future;Gene Expression;Genetic Transcription;Goals;Hippocampus;Human;human subject;Hypothalamic structure;Immune;immune activator;immune function;Immune signaling;Immune system;Immune System Diseases;Immunologic Factors;Immunologic Markers;Immunologic Receptors;Immunologic Sensitization;Impaired cognition;Individual;Inflammatory;Intervention;knock-down;late life;Learning;Magnetic Resonance Imaging;Measures;Memory;Memory impairment;Messenger RNA;Minor;Modeling;Molecular Target;Moods;Mus;neural;Neuroglia;Neuroimmune;New Mexico;new therapeutic target;novel;offspring;Outcome;overexpression;Pathway interactions;perceived stress;Peripheral Nerves;Phase;Population;posttranscriptional;Pre-Clinical Model;preclinical study;Predisposition;Prefrontal Cortex;Pregnancy;prenatal;Prevalence;Production;Protein Analysis;Proteins;Protocols documentation;Publishing;Receptor Activation;Regulation;Regulator Genes;Research;risk mitigation;Rodent;Saliva;Sex Differences;Short-Term Memory;Signal Pathway;Signal Transduction;spatial memory;Spinal;Spinal Cord;Stress;stressor;Testing;Thalamic structure;therapeutic target;Untranslated RNA;Visuospatial;young adult

PROJECT_TITLE: C5-Circular RNA's and immune sensitization


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Substance Misuse

PHR: PROJECT NARRATIVE Prenatal alcohol exposure (PAE) is the most common environmental cause of neurodevelopmental brain injury resulting in the development of fetal alcohol spectrum disorders (FASDs). Children with FASD exhibit persistent learning and behavioral disabilities, which may be due to white matter injury in the brain. The goal of our study is to investigate how alcohol impacts the gene expression and function of oligodendrocytes, the major glial cell type that is responsible for myelinating white matter tracts in a mouse model of FASD.

PI_NAMEs: VUE, TOU YIA  (contact)

PROJECT_TERMS: Adolescent;Adult;Affect;Age Months;alcohol behavior;alcohol exposure;Alcohols;Animal Model;Area;awake;Axon;Behavioral;Binding;Brain;Brain Injuries;Brain region;Cell Differentiation process;Cell Proliferation;cell type;Cells;Central Nervous System;Child;Clinical;Cognitive deficits;cognitive function;Complex;Corpus Callosum;Development;Diagnosis;disability;Electron Microscopy;emerging adult;Exhibits;experience;fetal;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Development;Fiber;Fluorescence-Activated Cell Sorting;Gene Expression;Gene Expression Profile;gene function;Genes;Genetic Transcription;Goals;gray matter;Heterogeneity;Human;human model;Immunoprecipitation;Impairment;Individual;Intervention;Knowledge;Label;Learning;Life;Location;Magnetic Resonance Imaging;Medial;Mediating;Membrane;Memory;Molecular;Motor Cortex;Motor Neurons;mouse model;mRNA sequencing;Mus;Myelin;Myelin Sheath;myelination;Neonatal;neonatal brain;neural;neurobehavioral;Neuroglia;neuronal cell body;Neurons;oligodendrocyte progenitor;Oligodendroglia;optogenetics;pharmacologic;Platelet-Derived Growth Factor;Play;Population;postnatal;precursor cell;Prefrontal Cortex;Process;Production;programs;Proliferating;Property;Reporter;Reporting;response;RiboTag;Role;Second Pregnancy Trimester;single cell genomics;single-cell RNA sequencing;Testing;Thalamic structure;Thick;Third Pregnancy Trimester;transcriptomics;Transgenic Mice;Undifferentiated;Visuospatial;white matter;white matter injury;Work

PROJECT_TITLE: C6-Development and adaptive myelination


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

PHR: Narrative The overall goal of the Pilot Project Core is to provide a critical opportunity to develop new basic, translational and clinical fetal alcohol research projects. Projects included in this application will 1) assess prenatal alcohol exposure-related changes in basic brain reward system function that may underlie both increased risk of alcohol use disorders and increased depression-like behavior; and 2) identify how prenatal alcohol exposure can make individuals more sensitive to repeated concussion-like injuries later in life.

PROJECT_TERMS: Adolescent;Advisory Committees;alcohol behavior;alcohol research;alcohol risk;alcohol use disorder;Alcohols;angiogenesis;Applications Grants;applied behavior analysis;Area;Award;Behavior;Brain;Brain Concussion;Cell Physiology;Cells;cerebrovascular;Cerebrovascular system;circular RNA;Clinical;Communities;Complement;Data;Decision Making;Development;Diagnosis;Disease Management;Doctor of Philosophy;Extramural Activities;Faculty;fetal;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Financial Support;forging;Fostering;Foundations;Functional disorder;Funding;Gene Expression Profile;gliogenesis;Goals;Grant;Growth;Head;Individual;Injury;Institution;Intervention;Life;Manuscripts;member;Mental Depression;Mentors;MicroRNAs;mild traumatic brain injury;Mind;Monitor;Mus;Neurosciences;New Mexico;novel strategies;pain processing;Pathology;Pharmacologic Substance;Phase;Pilot Projects;Placenta;Play;Positioning Attribute;prenatal;Preparation;professor;programs;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Resources;Rewards;Role;Science;Self Stimulation;single-cell RNA sequencing;success;System;Universities

PROJECT_TITLE: C7-Pilot Project core


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Armed combat predisposes to burn injury that can cause disfiguring scars and contractures in our Nation’s Veterans. We developed an immune-modulating biomaterial scaffold that allows mouse skin wounds to heal by regenerating new hair follicles and other skin structures. Here, we propose a series of experiments to test the hypothesis that immune-modulating biomaterials can regenerate tissue following burn injury, wounds that heal by scarring, tilting the balance toward a desirable regenerative response. These studies may unravel a new paradigm in burn wound management: providing a biomaterial scaffold to stimulate regenerative immune responses for optimal burn wound healing and skin regeneration.

PI_NAMEs: SCUMPIA, PHILIP  (contact)

PROJECT_TERMS: Ablation;Acceleration;acute wound;adaptive immune response;Adipose tissue;Adult;beta catenin;Biocompatible Materials;Bioinformatics;Biology;Biomedical Engineering;bioscaffold;Burn injury;burn therapy;burn wound;Cell Communication;Cells;Characteristics;Cicatrix;Clinical;combat;Communication;Contracture;Cosmetics;Data;Data Set;Deposition;Dermis;Development;Engineering;Equilibrium;Excision;experimental study;Extracellular Matrix;fetal;Fibroblasts;Fibrosis;Formulation;Functional disorder;Future;Genetic;Grant;Hair;Hair follicle structure;hair regeneration;healing;Histology;Human;Hydrogels;Immune;Immune response;Immune signaling;Immunology;immunoregulation;Impairment;improved;Inflammation;Inflammatory;innovation;Knowledge;Ligands;loss of function;Macrophage;Mammals;Methodology;microbiome;Microscopy;Military Personnel;Modality;Modeling;Molecular;Molecular Profiling;mouse model;Mus;mutant;Natural regeneration;Neomycin resistance gene;next generation;novel;novel therapeutics;overexpression;Pain;particle;Pathway interactions;Patients;Pattern recognition receptor;Phenotype;Population;Porosity;Postoperative Period;prevent;programs;receptor;Receptor Activation;Receptor Signaling;regeneration function;regenerative;Regenerative capacity;regenerative healing;Regenerative response;Regenerative wound healing;Resolution;Role;Science;Sebaceous Glands;Series;SHH gene;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;skin barrier;skin regeneration;skin wound;Speed;Structure;Sweat Glands;T-Lymphocyte;targeted treatment;Techniques;Temperature;Testing;therapy outcome;tissue regeneration;Tissues;transcriptomics;Transgenic Organisms;Translating;translational model;Veterans;Work;wound;wound care;wound closure;wound healing;Wound models;wound treatment

PROJECT_TITLE: Immunomodulatory biomaterials for regenerative healing of burn wounds


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

PHR: PROJECT NARRATIVE  Magnetic resonance spectroscopy (MRS) can measure the concentration of naturally occurring chemicals within the brain, often applying ‘edited’ methods which focus on one particular chemical and location. This project will develop new experimental methods that allow the simultaneous measurement of several chemicals simultaneously in multiple regions of the brain. The methods developed in this study will be disseminated to the neuroimaging community, and are expected to have a wide range of clinical and neuroscience applications.

PI_NAMEs: BARKER, PETER B (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: Aminobutyric Acids;arm;ascorbate;Aspartate;base editing;Brain;Brain region;Chemicals;Clinical;clinical application;Communities;computerized data processing;Consumption;data acquisition;Data Analyses;Data Collection;Data Set;Detection;Disease;experimental study;Glutamates;Glutathione;Goals;Head;Human;imaging approach;Imaging Techniques;improved;in vivo;Individual;Location;Magnetic Resonance Spectroscopy;Maps;Measurement;Measures;Methodology;Methods;model development;Morphologic artifacts;Motion;N-acetylaspartate;neuroimaging;Neurosciences;Noise;Non-Invasive Detection;Physiologic pulse;Process;prospective;Quality Control;reconstruction;Reproducibility;Scanning;Scheme;Signal Transduction;software development;Spatial Distribution;spectroscopic imaging;System;Techniques;Technology;Time;tool;Visualization

PROJECT_TITLE: Multi-voxel spectral editing at 3T

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Services;Mental Health;Mental Illness;Social Determinants of Health

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative In response to large numbers of senior center clients who suffer untreated depression and the dearth of geriatric mental health providers, we have simplified Behavioral Activation to be delivered by lay volunteers (“Do More, Feel Better”; DMFB). The focus of Behavioral Activation is to guide clients to reengage in daily pleasant and rewarding activities, and reduce depressive symptoms. If we can show that the lay delivery model has positive impact in comparison to MSW-delivered Behavioral Activation, we will have identified an effective intervention that can be used by a large untapped workforce of older adult volunteers across the nation.

PI_NAMEs: SIREY, JO ANNE  (contact)

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: Address;Aging;Area;Behavioral;Characteristics;Client;Clinical;Clinical Trials;clinically significant;Communities;community setting;cost;Dementia;Depressed mood;Depression screen;depressive symptoms;Diagnostic;disability;effective intervention;Effectiveness;effectiveness testing;effectiveness trial;Eligibility Determination;ethnic diversity;experience;Funding;Geography;geriatric mental health;Health;Health Personnel;improved;Individual;Infrastructure;Intervention;Label;Light;Mental Depression;Mental disorders;Mental Health;Modeling;National Institute of Mental Health;New York City;non-demented;Nutritional;older adult;Older Population;Outcome;Participant;Population;practice setting;Provider;Psychoses;psychosocial;Randomized;randomized effectiveness trial;Recreation;recruit;Reporting;Resources;response;Rewards;Safety;Sample Size;satisfaction;Service setting;Services;Severities;Site;skills;social;sociodemographic factors;sociodemographics;Supervision;Testing;Time;volunteer;Vulnerable Populations;Work;World Health Organization Disability Assessment Schedule

PROJECT_TITLE: 2/3 Lay-delivered Behavioral Activation in Senior Centers


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE / RELVANCE TO PUBLIC HEALTH After a heart attack, dead heart muscle is replaced by scar tissue. Scar tissue induces cardiac remodeling that leads to dilatation of heart chambers and development of heart failure. In this application, we identify and target a novel gene GPNMB for attenuating cardiac remodeling.

PI_NAMEs: DEB, ARJUN  (contact)

PROJECT_TERMS: Acute myocardial infarction;Adopted;Affect;Antisense Oligonucleotides;Attenuated;attenuation;Binding;Biological;Biological Markers;Biological Models;Biology;Bone Marrow Transplantation;Cardiac;Cardiac Myocytes;Cardiovascular Agents;Cells;Cicatrix;Circulation;Collaborations;Data;Dependovirus;Development;Diagnosis;Dilatation - action;Event;experimental study;Extracellular Domain;Extracellular Matrix;Fibroblasts;Fibrosis;gain of function;Genes;Genetic;genetic approach;Glycoproteins;GPR39 gene;healing;Heart;Heart failure;heart function;Heart Hypertrophy;Heart Injuries;heart preservation;hemodynamics;Heparitin Sulfate;Human;Human Genetics;Hypertrophy;in vivo;Inbred Strains Mice;Infarction;Injury;insight;Integral Membrane Protein;Isoproterenol;Ligand Binding;loss of function;Macrophage;Maps;Mediating;Melanoma;Mitochondria;mouse genetics;mouse model;multidisciplinary;Mus;Muscle Cells;Myocardial Infarction;Myocardium;Natural regeneration;Nonmetastatic;novel;Orphan;Pathway interactions;Peptide Hydrolases;pharmacologic;Pharmacologic Substance;Physiological;Physiology;Plasma;pressure;protein B;Proteins;Proteomics;Public Health;receptor;recruit;repaired;response;Role;Signal Pathway;Site-Directed Mutagenesis;Source;System;Therapeutic;Time;Tissues;trait;Wild Type Mouse;wound healing

PROJECT_TITLE: Role of GPNMB in cardiac remodeling


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Microbiome;Nutrition;Precision Medicine;Prevention

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Limiting blood sugar peaks following meals is an important treatment goal in the management of type 2 diabetes, but evidence is mixed regarding the best dietary approach to achieve this goal. One-size-fits-all dietary recommendations may fail to limit blood sugar peaks because individuals differ greatly in their blood sugar responses to the very same foods. In this study we will compare two Mediterranean-type diabetic diets, one that has been standardized and one that has been personalized using a gut microbiome-based algorithm to limit blood sugar peaks following meals.

PI_NAMEs: SEGAL, ERAN ;SEVICK, MARY A (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Address;adverse outcome;Affect;Algorithms;Amputation;Area;Area Under Curve;Behavioral;Behavioral Sciences;Beta Cell;Blood capillaries;Blood Glucose;Blood Vessels;Cardiovascular system;Cell Physiology;Clinical Trials;Computational Biology;Counseling;Dementia;design;Deterioration;Development;Diabetic Diet;Diet;dietary;dietary approach;Dietary intake;Dietary Intervention;Discipline of Nursing;Disease;Disease Progression;disorder risk;Education;Educational Materials;efficacy evaluation;Endocrinology;Epidemic;experience;Failure;Food;Frequencies;Frustration;genetic testing;Glucose;glucose monitor;glycemic control;Glycosylated hemoglobin A;Goals;gut microbiome;Health Technology;Heart Diseases;Hyperglycemia;Hypoglycemia;Individual;Intervention;Intervention Studies;Investigation;Kidney Diseases;lifestyle intervention;machine learning algorithm;Malignant Neoplasms;Measurement;Measures;Mediating;medication compliance;Mediterranean Diet;Metabolic;mHealth;microbiome;Modeling;Molecular Profiling;Nature;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional;Nutritional Study;Participant;Patients;Performance;personalized intervention;personalized medicine;personalized nutrition;Persons;Pharmaceutical Preparations;Polypharmacy;preservation;Randomized;randomized trial;Recommendation;Regimen;Research;Research Priority;response;Retinal Diseases;Risk;Schedule;Self Efficacy;Self Management;social cognitive theory;Standardization;Strategic Planning;Stroke;success;Technology;Time;treatment as usual;United States;United States National Institutes of Health;Variant

PROJECT_TITLE: Personalized Dietary Management in Type 2 Diabetes

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Immunization;Infectious Diseases;Liver Disease;Pediatric;Prevention;Vaccine Related;Women's Health Research

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Narrative This application of the Johns Hopkins Uganda Clinical Trials Unit (CTU) aims to include five clinical research sites in the Kampala and Rakai Districts of Uganda to conduct NIH HIV prevention and HIV therapeutic trials; each of these CRSs have unique and diverse populations to participate in HIV and related co infection trials. Some of these unique groups, including recently infected adults, long term surviving HIV Infected adults, adults co infected with HBV or TB, perinatally infected adolescents and young adults, HIV Infected mothers and HIV infected children, as well as high risk HIV negative adult and adolescents. The JHU-Uganda CTU and its CRSs propose to participate in The HIV Prevention, The HIV Vaccine, The Maternal, Adolescent, Pediatric Therapeutics, and the Adult Therapeutics Clinical Trials Networks supported by National Institutes of Health.

PI_NAMEs: FOWLER, MARY GLENN (contact);MUSOKE, PHILIPPA ;TOBIAN, AARON A

PROGRAM_OFFICER_NAME: TUCKER, JENESE

PROJECT_TERMS: Address;Adherence;Adolescent;Adolescent and Young Adult;Adult;AIDS prevention;Anti-Retroviral Agents;antiretroviral therapy;Area;Behavioral;Breast Feeding;Child;Childhood;Clinical Research;clinical research site;Clinical Treatment;Clinical Trials;Clinical Trials Network;Clinical Trials Support Unit;Clinical Trials Unit;co-infection;cohort;Conduct Clinical Trials;Country;Couples;Disease;Drug Delivery Systems;Drug Kinetics;Ebola;Emerging infection;Enrollment;Epidemic;Exposure to;Fishes;Funding;global health;Goals;Grant;Hepatitis B Infection;Hepatitis B Therapy;Hepatitis B Vaccines;Hepatitis B Virus;high risk;high risk population;High Risk Woman;HIV;HIV diagnosis;HIV Infections;HIV prevention trial;HIV Seronegativity;HIV vaccine;HIV Vaccine Trials Network;HIV-infected adolescents;HIV/AIDS;Immune;immunogenicity;immunological intervention;Immunotherapy;implementation science;improved;Infant;innovation;International;Intervention;Knowledge;Lactation;Lead;Leadership;Link;Long-Term Survivors;Manuscripts;men who have sex with men;Mentors;Metabolic;Modeling;Mother-to-child HIV transmission;Mothers;New Agents;Newly Diagnosed;next generation;novel;novel strategies;novel therapeutics;pandemic disease;pediatric human immunodeficiency virus;peri-urban;Perinatal;perinatal HIV;Pharmaceutical Preparations;Phase;Population;Population Heterogeneity;Populations at Risk;Postpartum Period;pre-exposure prophylaxis;pregnant;pregnant teen;Prevalence;Prevention;prevention clinical trial;Prevention trial;Prophylactic treatment;Protocols documentation;Records;recruit;Regimen;Research;Research Personnel;retention rate;Risk;Risk Reduction;Rural;rural setting;Safety;safety assessment;sex;Site;support network;System;Therapeutic;Therapeutic Agents;Therapeutic Clinical Trial;Therapeutic Trials;Training;Training Support;transmission process;treatment trial;tuberculosis treatment;Tuberculosis Vaccines;Uganda;United States National Institutes of Health;Universities;urban setting;vaccine immunogenicity;Vaccines;Vertical Disease Transmission;Woman;Writing;Youth

PROJECT_TITLE: The Johns Hopkins University - Uganda Clinical Trials Unit


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative The overarching goal of the following proposal is to evaluate the underlying mechanisms of heart failure in HIV through a combination of in vivo and in vitro studies that will use novel cardiac tissues, human pluripotent stem cell cardiac disease models and state-of-the art molecular approaches to probe the impact of HIV, immune activation and antiretroviral therapies, on the broad range of cell types comprising the human heart.

PI_NAMEs: CHI, NEIL C (contact);HSUE, PRISCILLA Y.

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Acute myocardial infarction;Address;Affect;Age Years;antiretroviral therapy;Arrhythmia;Autopsy;Behavior;Biology;Blood;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;cell behavior;Cell Communication;Cell Nucleus;cell type;Cells;Cessation of life;Chronic;Clinical;cohort;Collaborations;comorbidity;coronary fibrosis;Data;Diagnostic;Disease;disease model;Evaluation;Expression Profiling;Fibroblasts;gene regulatory network;General Population;Genetic Transcription;Genomic approach;Gifts;Goals;Heart;Heart Diseases;Heart failure;heart failure with reduced ejection fraction;heart function;high risk;HIV;HIV Infections;HIV therapy;HIV/AIDS;Homeostasis;Human;human pluripotent stem cell;Immune;immune activation;Immune system;In Vitro;in vivo;Incidence;individualized medicine;Inflammation;innovation;insight;Interdisciplinary Study;interest;interstitial;Lead;Lung;Methods;Modeling;Molecular;Myocardial Infarction;novel;Outcome;Pathogenesis;Pathologic;Pathologic Processes;Patients;Persons;Pilot Projects;Population;Process;programs;Research;Research Personnel;response;Risk;Risk Factors;Role;San Francisco;Science;Sleep;Stress;sudden cardiac death;Tissue Sample;Tissues;transcriptome sequencing;Translating

PROJECT_TITLE: Cell-Type Specific Mechanisms of HIV Cardiomyopathy

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: RELEVANCE (See instructions): We study how proteins and membranes are transported in the cell , a process known as intracellular transport. We have been focusing on the initial step of this process that involves the generation of transport carriers. As intracellular transport is a fundamental process that is required for proper cellular function, we anticipate that the results of our proposed studies will contribute to a better understanding of disease mechanisms.

PI_NAMEs: HSU, VICTOR W (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Accounting;Achievement;Affect;Articulation;Award;B-Lymphocytes;Binding;Biological Assay;cancer invasiveness;Capsid Proteins;Cell Physiology;Cell surface;Cells;Cilia;Clathrin;Coat Protein Complex I;Collaborations;Complex;Cues;Defect;Disease;Disparity;Electron Microscopy;Endoplasmic Reticulum;endoplasmic reticulum stress;Event;Family;Family member;follow-up;Funding;Future;Generations;Geometry;Goals;Golgi Apparatus;Growth Factor;Homeostasis;immunodeficiency;Impairment;in vivo;Individual;Induced Mutation;insight;Instruction;Intracellular Transport;Investigation;KDEL receptor;Link;Liposomes;Mediating;member;Membrane;Molecular;Monomeric GTP-Binding Proteins;Mutation;novel;Organelles;Physiological;Physiology;Point Mutation;Process;Protein Family;Proteins;receptor;reconstitution;reconstruction;Resolution;response;Retrieval;rho;Role;Sensory;Signal Induction;Signal Transduction;Sorting;Stress;T-Lymphocyte;Time;Transmembrane Transport;Tubular formation;tumor;Validation;Vesicle

PROJECT_TITLE: Mechanisms and Physiology of COPI Transport


NIH_SPENDING_CATS: Neurosciences

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Project Narrative. Neuronal circuits in the auditory cortex have the remarkable capacity to adjust to changes in the surrounding environment. This proposal will characterize a microcircuit that facilitates this plasticity in the adult auditory cortex. We envision that the results of this research will lead to new therapeutic strategies to treat hearing and communication disorders that tap into specific synaptic and cellular mechanisms to promote adult auditory plasticity and learning.

PI_NAMEs: TAKESIAN, ANNE E (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Acute;Address;Adult;Anatomy;Auditory;Auditory area;auditory thalamus;Axon;Behavior;Behavioral;Brain;brain cell;Brain region;Calcium;cell type;Cells;cholinergic;Communication impairment;Complex;Data;Development;Electrophysiology (science);Environment;experience;experimental study;Genetic Transcription;hearing impairment;Hearing problem;Image;In Vitro;in vivo;Interneurons;Laboratories;Learning;Life;Locomotion;Maps;Measures;Medial geniculate body;Mediating;Modality;Monitor;Mus;Neuromodulator;neuronal circuitry;Neuronal Plasticity;Neurons;neuroregulation;neurotrophic factor;novel therapeutic intervention;optogenetics;Outcome;Output;Pathway interactions;Pattern;Perceptual learning;Peripheral;Population;postsynaptic;presynaptic;Property;Rabies;receptor;Recovery;recruit;reinforcer;Research;response;Rewards;Sensory;sensory cortex;sensory input;Signal Transduction;Site;Slice;sound;Stimulus;Synapses;System;Techniques;Technology;Thalamic structure;two-photon;Vasoactive Intestinal Peptide;vigilance;Viral;Work

PROJECT_TITLE: Differential Control of Auditory Cortex by Two Populations of Layer 1 Interneurons

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE: Heparin induced thrombocytopenia (HIT) is an allergic reaction to a commonly used blood thinner (heparin) that causes life-threatening clots. It is becoming increasingly clear that the standard approach of using alternative blood thinners for HIT treatment does not prevent many complications. In this proposal, we are examining other approaches to dampen the allergic response by blocking inflammation.

PI_NAMEs: AREPALLY, GOWTHAMI M (contact);CINES, DOUGLAS BROCK;RAUOVA, LUBICA

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: activation product;Affect;Allergic Reaction;allergic response;Amputation;Antibodies;Anticoagulants;Anticoagulation;Antigen-Antibody Complex;Antigens;Binding;Biological Assay;Blood Platelets;cell injury;Cell surface;Cells;Cessation of life;Charge;Classical Complement Pathway;Clinical;Clinical Research;clinically relevant;Coagulation Process;Complement;Complement 1q;complement 1q receptor;Complement 3a;Complement 5a;Complement Activation;complement C3 precursor;Complement Inactivators;Complement Membrane Attack Complex;complement pathway;Complement Receptor;Data;Deposition;design;Disease;Effectiveness;efficacy evaluation;endothelial cell procoagulant activity;Endothelial Cells;Endothelium;Factor Xa;Future;Hemorrhage;Heparin;Heparin Binding;heparin-induced thrombocytopenia;high risk;Immunoglobulin G;Impairment;in vivo;Inflammation;Inflammatory;inhibitor;insight;Intervention;Investigation;Knowledge;Laboratory Study;Life;light scattering;Lytic;Maximum Tolerated Dose;Mediating;Microfluidics;Modeling;monocyte;Morbidity - disease rate;mortality risk;mouse model;Mus;neutrophil;Nonlytic;novel;Outcome;Pathogenesis;Pathway interactions;Patients;PF4 Gene;Plasma;potential biomarker;pre-clinical;Predisposition;prevent;Procedures;public health relevance;Publishing;Recurrence;Regulation;response;Risk;Role;Safety;seropositive;Signal Transduction;Surface;Testing;Therapeutic;Thrombin;Thromboembolism;Thromboplastin;Thrombosis;thrombotic;thrombotic complications;Thrombus;Time;treatment strategy;von Willebrand Factor;Whole Blood

PROJECT_TITLE: Complement and Thrombosis in HIT

STUDY_SECTION: HT

STUDY_SECTION_NAME: Hemostasis and Thrombosis Study Section.  Committee was terminated on 11/30/2020. [HT]


NIH_SPENDING_CATS: Aging;Cardiovascular;Contraception/Reproduction;Estrogen;Heart Disease;Women's Health Research

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Pre-menopausal women display a significantly lower incidence of cardiovascular disease than age-matched men, however this relative protection is lost after menopause. While reduced estrogen levels in post- menopausal women have been linked to this loss of protection, the biological mechanism is not fully understood. In this proposal, we seek to understand whether changes in cardiac metabolism, caused by reduced estrogen levels, make the hearts of post-menopausal women more susceptible to injury and disease.

PI_NAMEs: SCOTT, IAIN  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Acetylation;Acetyltransferase;Address;Adult women;Age;Attenuated;Biochemical;Biological;Cardiac;Cardiac health;cardioprotection;Cardiovascular Diseases;Cell Line;Cells;Data;Development;Disease;Energy Metabolism;enzyme activity;Enzymes;Estrogen decline;Estrogen Therapy;Estrogens;Exhibits;fatty acid oxidation;Female;functional decline;Future;Goals;Heart;Heart Diseases;Heart failure;heart metabolism;Human;improved;In Vitro;in vivo;Incidence;Injury;Knock-out;Knockout Mice;Laboratories;Link;Lysine;male;Measures;Mediating;men;Menopause;Metabolic Pathway;Metabolism;Mission;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;Molecular Target;mouse model;Mus;Myocardial dysfunction;Myocardium;National Heart, Lung, and Blood Institute;novel;Output;Ovarian Ablation;Ovarian Follicle;overexpression;Pathologic;Pathway interactions;Postmenopause;Predisposition;Premenopause;pressure;Production;Protein Acetylation;Proteins;Regulation;Regulator Genes;response;Role;Series;Signal Transduction;Stimulus;Stress;Testing;Therapeutic Intervention;tool;Transgenic Mice;Wild Type Mouse;Woman;young adult

PROJECT_TITLE: Fatty acid oxidation in female cardioprotection

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The protective activity of the pro-inflammatory cytokine interleukin-6 (IL-6) is regulated by its circulating soluble receptor (sIL6R) that captures IL-6 from solution to coordinate immune signaling following infection or tissue damage. We find that within mice, sIL6R is almost exclusively generated by a single immune cell lineage, conventional dendritic cells (cDC). In this proposal, we will define how sILR6 biogenesis occurs within the cDC, and how then this cDC-regulated immune defense activity can be manipulated to both enhance vaccine responsiveness and reverse genetic inflammatory diseases that arise due to sIL6R insufficiency.

PI_NAMEs: LINGWOOD, DANIEL  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: adaptive immunity;Adjuvant;Animals;Antibodies;Antibody Response;Antigens;B cell differentiation;B-Lymphocytes;Biogenesis;Biology;Buffers;Cell Line;Cell Lineage;Cell membrane;Cell surface;Cells;chronic inflammatory disease;Circulation;combinatorial;Complex;conditional knockout;cytokine;Data;defined contribution;Dendritic Cells;Disease;druggable target;Embryo;Engineering;Evaluation;Failure;functional restoration;Gene Delivery;Genetic;Genetic Polymorphism;Goals;Half-Life;Homeostasis;Human;human disease;Humoral Immunities;IL6R gene;Immune;Immune response;Immune signaling;Immunity;Immunization;immunodeficiency;Immunoglobulins;Immunologic Receptors;Immunology;immunoreaction;immunosuppressed;improved;in vivo;Infection;Infiltration;Inflammatory;influenza virus vaccine;Innate Immune Response;Interleukin 6 Receptor;Interleukin-6;Knock-out;Knockout Mice;Laboratories;Link;Lymphoid;Lymphoid Cell;Mediating;Medical Faculty;medical schools;member;Metalloproteases;Mission;Modality;mouse model;Mus;Natural Immunity;novel;Output;Pathway interactions;Peptide Hydrolases;Phase I Clinical Trials;Plasma Cells;prevent;professor;Property;Proteins;receptor;receptor expression;reverse genetics;Serum;Signal Transduction;Site;Source;Surface;System;T-Lymphocyte;targeted treatment;Testing;Therapeutic;tissue injury;tissue/cell culture;Tissues;transcription factor;Transgenic Animals;United States National Institutes of Health;universal influenza vaccine;Vaccination;Vaccine Adjuvant;Vaccine Antigen;vaccine response;Vaccines

PROJECT_TITLE: Systemic coordination of pro-inflammatory immune reactions through dendritic cell-restricted sIL6R biogenesis

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]