ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Clinical Research;Regenerative Medicine

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Three-dimensional (3D) bioprinting technologies have been accelerating at a rapid pace and could be revolutionary for precision medicine, enabling the precise manufacturing of cells, tissues, and organs for both clinical care and biomedical research. In order for these 3D bioprinting technologies to be ethically and equitably designed, developed, and used, researchers must hone their skills to address not only the scientific challenges (such as vascularization challenges that impede biofabrication of complex structures) but also the ethical, legal, and social issues (ELSI) arising with them. This project will boost bioethics and bioprinting research capacity with high quality educational opportunities and resources.

PI_NAMEs: OZBOLAT, IBRAHIM  (contact)

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Animal Model;Area;Awareness;Bioethics;biofabrication;Biological Sciences;biological systems;Biomedical Engineering;biomedical imaging;Biomedical Research;bioprinting;bone;Bone Tissue;career;Case Study;Cells;clinical care;clinical translation;Communities;Competence;Complex;Craniofacial Abnormalities;craniofacial repair;Data Science;design;Development;Discipline;disease model;Drug Screening;Education;education resources;effectiveness testing;Emerging Technologies;Engineering;Enrollment;Equity;ethical, legal, and social implication;Ethics;experience;fabrication;Faculty;functional restoration;Future;Hour;improved;In Vitro;innovation;insight;Instruction;instructor;Intellectual Interest;Intention;interdisciplinary collaboration;interest;Lasers;Laws;Lawyers;Learning;Learning Module;Legal;manufacture;multidisciplinary;National Institute of Biomedical Imaging and Bioengineering;new technology;novel;Operative Surgical Procedures;Organ;Organ Transplantation;Parents;Phase;Policies;Policy Maker;precision medicine;Process;programs;Public Health Informatics;Rattus;recruit;Regenerative Medicine;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Respiratory System;response;Role;Safety;Science Policy;Science, Technology, Engineering and Mathematics;Scientist;self-directed learning;Series;Shapes;skills;Societies;spheroids;Structure;Students;support tools;Techniques;Technology;technology development;Testing;Tissue Model;Tissues;Trachea;Training;Transcend;United States National Institutes of Health;Universities;Vascularization;video module;webinar;Work;Writing

PROJECT_TITLE: Boosting Bioethics & Bioprinting

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Orphan Drug;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: EAST LANSING

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: We discovered that mutations in a centrosome protein rotatin (RTTN) cause infantile heart failure by disrupting the heart maturation program that normally occurs after birth. In this study, we will examine how RTTN regulates this process through a structure called the perinuclear microtubule organizing center (pnMTOC) and how this gene and others in the complex disrupt the sarcomere (the contractile unit) in cardiomyocytes. Our study will reveal how defects in certain centrosome proteins cause infantile heart failure and help develop new therapies for this devastating childhood illness.

PI_NAMEs: HONG, CHARLES C (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: 1 year old;Adult;AKAP9 gene;Architecture;Birth;Cardiac;Cardiac Myocytes;causal variant;Cell Cycle;Cell Physiology;cell type;Cellular Structures;Centrioles;Centrosome;chemical genetics;Childhood;Complex;Cytoskeleton;Defect;Dependence;Dilated Cardiomyopathy;Disease;Dissection;Drosophila genus;drug development;Exhibits;experimental study;Failure;familial dilated cardiomyopathy;Functional disorder;Future;Genes;Genetic;Genetic Predisposition to Disease;Heart;Heart Diseases;Heart failure;heart function;Human;Impairment;improved;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;infancy;Infant;innovation;insight;knock-down;Knowledge;Label;Light;Medical;Microcephaly;Microtubule-Organizing Center;Microtubules;Mitochondria;Modeling;Molecular;molecular dynamics;Molecular Structure;mutant;Mutation;National Heart, Lung, and Blood Institute;ninein;novel therapeutic intervention;novel therapeutics;Nuclear;Nuclear Envelope;Pathogenesis;Pathway interactions;Patients;Pediatric Cardiomyopathy;pediatric heart failure;Play;postnatal;precision medicine;prevent;Process;Prognosis;programs;Proteins;Research;Role;Sarcomeres;Skeletal Muscle;small molecule;Structure;Zebrafish

PROJECT_TITLE: Mechanistic Insights into The Role of Microtubule Organizing Centers on Cardiomyocyte Structure and Function

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Hematology;Infectious Diseases;Inflammatory Bowel Disease;Microbiome;Sepsis

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: NARRATIVE The Gram-negative bacterial pathogens Escherichia coli and Salmonella infect the gastrointestinal tract and are leading causes of morbidity in diverse patient populations. Infections caused by these pathogens pose a significant and urgent threat to public health and developing new antimicrobial strategies that target these organisms with minimal impact on the gut microbiome are needed. The transition metal iron (Fe) is an essential nutrient for E. coli and Salmonella, and the Fe-acquisition systems these pathogens use to obtain Fe from the host may provide new non-traditional antibacterial approaches that target these pathogens.

PI_NAMEs: NOLAN, ELIZABETH M;RAFFATELLU, MANUELA  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Adherent Invasive Escherichia coli;Affect;Anaerobic Bacteria;Anti-Bacterial Agents;Antibiotics;Antibodies;antimicrobial;Applications Grants;Bacteremia;Binding;Colitis;Crohn's disease;design;Development;Diarrhea;enteric pathogen;Enterobactin;Environment;Escherichia coli;Future;Gastrointestinal tract structure;Genes;Growth;gut inflammation;gut microbiome;Gut Mucosa;Immunization;In Vitro;in vivo;Infection;Inflammatory;Inflammatory Bowel Diseases;Iron;Laboratories;Mediating;Meningitis;microbiome composition;microbiota;Morbidity - disease rate;Mucous Membrane;Mus;mutant;non-typhoidal Salmonella;Nutrient;Organism;pathobiont;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;patient population;Patients;Public Health;Research;Salmonella;Salmonella typhimurium;scaffold;Sepsis;Siderophores;Site;System;Testing;Therapeutic;Transition Elements;uptake;Urinary tract infection;Work

PROJECT_TITLE: Harnessing iron acquisition to hinder enterobacterial pathogenesis


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative This diversity supplemental fund application is closely relevant to the ongoing research proposed in the parent R01 grant and significantly extends the scope of the main project, which will further investigate roles of a key histone modifier LSD1 in breast tumorigenesis and tumor microenvironment. The results from the proposed studies are expected to provide key preclinical data, novel mechanistic insight, and rationales to address their mechanistic and clinical associations between epigenetic defects and TNBC tumor microenvironment. In the long run, these studies may lead to new and improved therapies for patients with relapsed and refractory TNBC.

PI_NAMEs: HUANG, YI  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Ablation;Address;Age Months;anti-PD-1;BRCA1 gene;Breast Cancer Cell;breast cancer progression;Breast Cancer Risk Factor;breast tumorigenesis;cancer initiation;Career Mobility;CD8-Positive T-Lymphocytes;chemokine;chemotherapy;Clinical;clinically relevant;conditional knockout;CXCL10 gene;CXCL9 gene;Cytotoxic T-Lymphocytes;Data;Defect;demethylation;Development;effector T cell;Environment;Epigenetic Process;epigenetic silencing;Functional disorder;Funding;Genes;Genetically Engineered Mouse;Genome Stability;Goals;Grant;high risk;Histones;Immune;immune checkpoint blockade;immunogenic;improved;in vivo;Incidence;inducible Cre;insight;KDM1A gene;Knockout Mice;Lactation;Link;Lymphocyte;Lysine;Malignant Breast Neoplasm;Mammary gland;Mammary Neoplasms;Matrix Metalloproteinases;Mediating;Molecular;mortality;mouse model;Mus;Mutate;Mutation;Neoplasm Metastasis;novel;Outcome;overexpression;parent grant;Parents;Pathogenesis;Patients;Play;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Pregnancy;Prognosis;programs;Promoter Regions;RANTES;Refractory;Relapse;Repression;Research;Research Project Grants;Resistance;Role;Shapes;T cell infiltration;targeted treatment;therapy resistant;tissue-factor-pathway inhibitor 2;trafficking;treatment response;triple-negative invasive breast carcinoma;tumor;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Suppressor Genes;Xenograft procedure

PROJECT_TITLE: Role of LSD1 in Triple Negative Breast Cancer Development and Therapeutic Response

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PI_NAMEs: LIN, YI  (contact)

PROGRAM_OFFICER_NAME: UJHAZY, PETER

PROJECT_TERMS: Ablation;Adopted;Aftercare;Apoptosis;Bispecific Antibodies;bone cell;Bone Marrow;CARTPT gene;cell killing;Cell Line;Cell Physiology;Cell Therapy;Cells;Cessation of life;chemotherapy;Chemotherapy and/or radiation;Clinic;Clinical;Clinical Trials;Complex;cytokine;Data;Disease remission;Exhibits;Exposure to;Fc domain;FDA approved;Fibroblasts;Flow Cytometry;Functional disorder;Gene Expression Profile;Growth;Immunophenotyping;improved;In Vitro;Infusion procedures;Innate Immune Response;Ligands;Link;Mediating;Multiple Myeloma;Myelogenous;nanobodies;neoplastic cell;novel;novel strategies;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Pre-Clinical Model;Proliferating;Proteins;Publishing;receptor;Recurrent disease;Refractory;Relapse;relapse patients;Resistance;resistance mechanism;response;senescence;Signal Transduction;standard of care;Stem cell transplant;T cell therapy;T-Lymphocyte;Testing;therapeutic development;therapy resistant;trafficking;transcriptome sequencing;transplantation therapy

PROJECT_TITLE: Project 4: Targeting Resistance to T-Cell Directed Therapy in Multiple Myeloma


ED_INST_TYPE: COMPUTER CENTER

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Activity;Prevention;Sleep Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: IRVINE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: The proposed project will have potentially profound impacts on applying mobile health and artificial intelligence to address health disparities in the U.S. By harnessing deep learning capabilities for extracting predictive features and integrating prior domain knowledge to define human-interpretable states, our proposed research will create a new framework for analyzing individual health data and understanding how reducing individuals’ stress, increasing physical activities, maintaining healthy glucose levels, and improving sleep patterns could effectively reduce cancer-related risk factors. The project will also provide fundamental and rigorous solutions for handling common challenges in mobile health data analysis, addressing issues such as irregular data collection, multi-resolution data features, and subject heterogeneity.

PI_NAMEs: GUO, YUQING ;QU, ANNIE  (contact);SHAHBABA, BABAK ;SMYTH, PADHRAIC

PROGRAM_OFFICER_NAME: WOLFF-HUGHES, DANA L

PROJECT_TERMS: Address;Adoption;Affect;Artificial Intelligence;Behavior;biopsychosocial;biopsychosocial factor;Blood Pressure;Chronic;Clinical;Community Health Aides;Complex;Computational Science;critical period;Data;Data Analyses;Data Collection;data integration;Data Set;Data Sources;deep learning;Development;Diabetes Mellitus;digital health;Disease;empowerment;ethnic diversity;flexibility;Foundations;Frequencies;General Population;Glucose;Growth;Health;health application;health care settings;health data;health disparities in women;health disparity;Health Personnel;Health Status;Healthcare Systems;Heart Rate;heart rate variability;Heterogeneity;heterogenous data;high dimensionality;Home;Human;Hypertension;improved;improvement on sleep;Individual;individual variation;individualized prevention;Inflammation;Information Sciences;innovation;insight;Intervention;Knowledge;Learning;Life;life span;Machine Learning;machine learning method;machine learning prediction;Malignant Neoplasms;Maps;marginalization;Measurement;Methodology;Methods;mHealth;Minority Groups;Modeling;Monitor;multidimensional data;multimodal data;neglect;neural model;novel;Outcome;Pattern;Personal Satisfaction;personalized intervention;Physical activity;Policies;Population Heterogeneity;Pregnancy;Prevention strategy;Psychological reinforcement;rapid growth;Recommendation;Reduce health disparities;Research;Resolution;response;Rewards;Risk Factors;Sampling;Series;Signal Transduction;Sleep;sleep pattern;smartphone based device;social health determinants;Source;Statistical Models;Stress;Techniques;Technology;Time;time interval;Translations;Variant;wearable data;wearable device;Woman;Women's Health;Work;World Health

PROJECT_TITLE: SCH: Individualized learning and prediction for heterogeneous multimodal data from wearable devices

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-N (50)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Immunization;Immunotherapy;Rare Diseases;Vaccine Related

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Not Requested

PI_NAMEs: SELVARAJ, PERIASAMY ;SHIN, DONG M (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: anti-PD1 antibodies;Head and Neck Squamous Cell Carcinoma;Metastatic Squamous Cell Carcinoma;Recurrence;vaccine immunotherapy

PROJECT_TITLE: Personalized vaccine immunotherapy in combination with anti-PD 1 antibody for recurrent or metastatic squamous cell carcinoma of the head and neck


ORG_CITY: RICHMOND

ORG_DEPT: SURGERY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Narrative The United for Health Equity-Living PDX Program (U4HELPP) seeks to develop, characterize and test >500 new patient-derived xenograft (PDX) models from underrepresented patient populations such that our research studies can more adequately represent the diverse patient population that our cancer center serves.

PI_NAMEs: HARRELL, JOSHUA (CHUCK) ;TREVINO, JOSE G. (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Award;Bioinformatics;Black race;Breast;Cancer Center;cancer health disparity;Cancer Model;cancer type;Clinical;Clinical Trials;Colon;Cryopreservation;Data;disorder subtype;Genetic;Genomics;Goals;Grant;Growth;health equity;insight;Institution;Investigational Drugs;Liver;Lung;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Mediating;Neoplasm Metastasis;novel drug combination;Pancreas;Pathway interactions;patient derived xenograft model;patient population;Patients;peritoneal cancer;Pilot Projects;programs;proteogenomics;Proteomics;Research Personnel;Research Project Grants;research study;Resources;response;safety net;Surgeon;System;targeted treatment;Testing;therapeutically effective;tumor;Underrepresented Populations

PROJECT_TITLE: United for Health Equity - Living PDX Program (U4HELPP)


ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Lung cancer is the leading cause of cancer mortality in the United States. Targeted therapies, such as growth factor receptor (EGFR) inhibitors, and immunotherapy have improved survival outcomes, but require genetic testing as a basis for treatment, which may not be performed equally across patients. We propose to study disparities in access to genetic testing as one of the ways to explain existing gaps in non-small cell lung cancer (NSCLC) prognosis between Black and White patients, as well as rural and urban patients.

PI_NAMEs: TAIOLI, EMANUELA  (contact)

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: access disparities;Address;Adjuvant;anaplastic lymphoma kinase;anti-cancer research;Black race;BRAF gene;Cancer Etiology;cancer genomics;Cancer Patient;Cancer Prognosis;chemotherapy;clinical practice;Complement;Data;Data Set;Disparity;druggable target;Eligibility Determination;Epidermal Growth Factor Receptor;Ethnic Origin;Genetic;genetic testing;Growth Factor Receptors;Health Disparities Research;Histology;Immunotherapy;improved;inhibitor;KRAS2 gene;large datasets;Malignant neoplasm of lung;Malignant Neoplasms;Medicare;Medicare claim;Minority;Mission;Molecular;mortality;Mutation;Neoplasm Metastasis;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Oncogenic;Operative Surgical Procedures;Outcome;parent grant;Pathway interactions;Patients;Pharmaceutical Preparations;population based;Prevalence;programmed cell death ligand 1;programmed cell death protein 1;Proteins;Quality of Care;Race;Receptor Protein-Tyrosine Kinases;Research;Rural;Socioeconomic Status;Statistical Data Interpretation;survival disparity;survival outcome;Survival Rate;Systemic Therapy;targeted treatment;Testing;training opportunity;tumor;United States;Work

PROJECT_TITLE: Disparities in molecular testing among non-small cell lung cancer patients


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BOZEMAN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: Project Narrative This supplement to the Montana IDeA Network of Biomedical Research Excellence grant will support the development of data science educational and computer resources for students and researchers across the state. The proposed work will also use collaborative team-teaching efforts and workshops to foster connections between research-intensive universities, Tribal colleges, and other institutions that support undergraduate education in Montana. These efforts will strengthen the capacity for data-driven biomedical research and student training across tribal and rural communities of Montana.

PI_NAMEs: BOTHNER, BRIAN P (contact)

PROGRAM_OFFICER_NAME: NANDA, JAGPREET SINGH

PROJECT_TERMS: Bioinformatics;Biomedical Research;Collaborations;Communities;computer infrastructure;Computers;computing resources;cyber infrastructure;Data;data integration;Data Science;data science education;Development;Educational workshop;Ethics;Five-Year Plans;Fostering;Foundational Skills;generative artificial intelligence;genome sciences;Genomics;Grant;Health Sciences;High Performance Computing;improved;Informatics;Institution;Instruction;Interdisciplinary Study;interest;Intuition;Learning;Montana;programs;Research;research and development;Research Personnel;Research Training;Resources;Rural Community;Rural Health;Salish Kootenai College;Series;Site;Site Visit;student training;Students;symposium;teacher;teacher community;Training;tribal college;tribal community;undergraduate education;undergraduate student;Universities;web based interface;Work

PROJECT_TITLE: MT INBRE: A Multidisciplinary Research Network


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Neurosciences;Pediatric;Substance Misuse

PHR: PROJECT NARRATIVE This proposal is designed to enhance the infusion of diversity, equity, and inclusion (DEI) principles throughout the HEALthy Brain and Child Development (HBCD) Study through leadership expansion, DEI training, education, and evaluation of best practices. This proposal is also designed to ensure that recruitment and retention of the appropriately representative and diverse study sample is achieved and maintained through leadership expansion and establishment of a metrics committee. The HBCD Consortium Administrative Core will appoint Associate Directors of DEI and Recruitment and Retention with appropriate experience who will each lead and expand on the coordinated efforts already underway within HBCD.

PI_NAMEs: CHAMBERS, CHRISTINA  (contact);NELSON, CHARLES ALEXANDER

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Address;Brain;Child Development;Dedications;design;Education;Ensure;equity, diversity, and inclusion;Evaluation;experience;Family;Infusion procedures;Intervention;Lead;Leadership;Monitor;recruit;Sampling;Sampling Studies;Strategic Planning;Structure;success;Training;working group

PROJECT_TITLE: The Healthy Brain and Child Development National Consortium Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(51)-R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Aberrant Protein Kinase A (PKA) signaling drives the growth and progression of a subset of lung, ovarian, liver, adrenal and gastrointestinal tumors. Pharmacologically targeting these aggressive cancers is challenging as directly inhibiting PKA has dire consequences such as heart failure, kidney dysfunction and diabetes. This multi- investigator project tests if PKAc-driven cancers can be treated by targeting its downstream effects on mRNA translation by inhibiting the helicase eIF4A rather than globally blocking the activity of the kinase.

PI_NAMEs: GORDAN, JOHN D (contact);SCOTT, JOHN D

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: A kinase anchoring protein;adenoma;Adrenal Gland Neoplasms;Apoptosis;Applications Grants;Atrial myxoma with lentigines;BAG2 gene;Binding;Biochemical;Biogenesis;Biology;c-myc Genes;c-myc Proto-Oncogenes;Caring;Catalytic Domain;CCL4 gene;Cell Line;Cells;chaperonin;Chemicals;Clinical;Clinical Research;clinically relevant;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Dependence;derepression;Development;Diabetes Mellitus;Disease Progression;Drug Targeting;effective therapy;Elements;Endocrine Gland Neoplasms;Fibrolamellar Hepatocellular Carcinoma;forging;Foundations;Gastrointestinal Neoplasms;Gene Targeting;Generations;Genetic;Genetic Transcription;Growth;Heart failure;heat-shock proteins 40;Heat-Shock Proteins 70;helicase;Holoenzymes;in vivo;Incidence;Induction of Apoptosis;inhibitor;Island;kidney dysfunction;Lesion;Link;live cell imaging;Liver neoplasms;Lung;Lung Neoplasms;Malignant Neoplasms;Modeling;Molecular;mRNA Translation;mutant;Mutation;nano;nanoscale;novel;Oncogenic;Oncology;Outcome;Output;ovarian neoplasm;parent grant;Pathway interactions;Patient Care;patient derived xenograft model;Patients;Peptide Initiation Factors;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;Physiological;Physiological Processes;Production;Proliferating;Property;Protein Inhibition;Protein Kinase;Protein-Serine-Threonine Kinases;Proteins;Proteomics;Radial;rare cancer;Rare Diseases;recruit;Regimen;Regulation;Research;Research Personnel;Resistance;response;Ribosomes;RNA Helicase;Role;Second Messenger Systems;Serine;Signal Transduction;Solid;Specificity;targeted treatment;Testing;Therapeutic;Therapeutic Index;therapeutic target;Tissue Sample;tool;Toxic effect;transcriptomic profiling;translational impact;Translational Repression;Translations;tumor;tumor growth;United States Food and Drug Administration;United States National Institutes of Health;Variant

PROJECT_TITLE: Characterizing the biochemical mechanisms of oncogenic signaling by mutant Protein Kinase A


ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative. The integration of electronic health records (EHR) and analysis of real-world data (RWD) have revolutionized clinical and translational research (CTR), with significant implications for public health. However, gaps in data granularity and expertise have hindered scientific breakthroughs, delaying progress. The University of Oklahoma Health Sciences Center proposes to expand data science infrastructure and foster cross-disciplinary partnerships to address these challenges, aiming to accelerate research efforts and position Oklahoma as a leader in health data innovation.

PI_NAMEs: JAMES, JUDITH A (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Acceleration;Address;Administrative Supplement;Award;Clinical;Clinical Research;Clinical Sciences;Collaborations;Data;data resource;Data Science;data science infrastructure;Diabetes Mellitus;Electronic Health Record;Ensure;Fostering;Health;health data;health disparity;Health Sciences;Healthcare;Information Retrieval;innovation;Malignant Neoplasms;Oklahoma;Positioning Attribute;Public Health;Research;Resources;Substance abuse problem;Text;Translational Research;Universities

PROJECT_TITLE: Oklahoma Shared Clinical and Translational Resources


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Patient engagement in research and clinical practice holds promise for closing gaps across the substance use disorder (SUD) use and treatment cascade. Despite increasing recognition of the importance of engaging patients in SUD research and clinical practice, as well as NIDA’s commitment to patient engagement, we have limited understanding of best practices for patient engagement in the SUD field. Patient engagement frameworks are tools that help stakeholders support, evaluate, improve, and report on patient involvement in research and clinical practice. Yet, patient engagement frameworks that are tailored to the unique needs of patients and communities impacted by SUD are nascent. Therefore, our short-term goal for this project is to tailor a patient engagement framework for SUD research and clinical practice in partnership with the Addiction Policy Forum (APF), a nationwide organization dedicated to eliminating addiction. In Aim 1, we will engage in bioethics research to identify key elements of SUD patient engaged research and clinical practice via concept mapping. Concept mapping is a community-based participatory, mixed-methods approach that has been used in past work both to develop community engagement frameworks and with populations affected by SUD. We will follow recommended steps for using concept mapping in community-based participatory research, including: patient preparation, patient brainstorming, patient sorting and rating, multivariate statistical analysis, and patient interpretation. Participants will include individuals recruited from APF’s patient panels focused on individuals with active use (n=25) and in treatment and recovery (n=25). In Aim 2, we will tailor a patient engagement framework for SUD research and clinical practice. We will choose a patient engagement framework for tailoring by comparing results from Aim 1 to existing, well-established patient engagement frameworks. We will then tailor the framework by integrating results from Aim 1, and iteratively revise it with patients and experts in SUD research and clinical practice. This project will be conducted alongside our ongoing randomized controlled trial of a disclosure intervention for people in recovery from opioid use disorder (R01DA059557). We will therefore immediately apply the framework to our ongoing trial. Additionally, our long-term goals are to disseminate and evaluate the resulting SUD patient engagement framework. We will disseminate the framework via peer- reviewed publications and tailored, translated products for patients and other key stakeholders so that it can be applied to SUD research and clinical practice. We also plan to evaluate and, if needed, refine the framework in the context of future studies (e.g., with R21 or R01 funding). Our ultimate goal is to produce a SUD patient engagement framework that is flexible (so that it can be used with patients impacted by a variety of SUDs, who are engaged in active use and in treatment/recovery, as well as in both research studies and clinical practice) and adaptable (because the SUD epidemic is dynamic and often rapidly evolving).

PI_NAMEs: EARNSHAW, VALERIE ANN (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Academy;addiction;Address;Adult;Affect;barrier to care;Benchmarking;Bioethics;clinical practice;Communities;community based participatory research;community engagement;concept mapping;Consult;Dedications;design;Development;Disclosure;Elements;Ensure;Epidemic;experience;flexibility;Fright;Funding;Future;Goals;improved;Individual;Intervention;Literature;Maps;Medicine;Methods;Modeling;National Institute of Drug Abuse;Nonprofit Organizations;opioid use disorder;Outcome;overdose death;Participant;patient engagement;patient oriented;Patient Recruitments;Patients;Peer Review;Persons;Policies;Population;Preparation;Protocols documentation;Public Health;Publications;Publishing;Randomized, Controlled Trials;Recommendation;Recovery;recruit;Reporting;Research;research study;social stigma;Sorting;Statistical Data Interpretation;Substance Use Disorder;systematic review;tool;Translating;United States;Work

PROJECT_TITLE: Tailoring a patient engagement framework for substance use disorder research

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Breast cancer brain metastasis (BCBM) is associated with deadly outcomes due to limited therapeutic options and poor response, urgently calling for the development of novel therapeutic intervention strategies. We have found that oncolytic herpes simplex virus-1 (oHSV) therapy induces neutrophil infiltration and neutrophil extracellular trap (NET) formation through induction of Insulin-like growth factor-2 (IGF2) expression and secretion into tumor microenvironment (TME), hampering therapeutic efficacy of oHSV. In this proposed research, we will uncover the mechanistic relationship between oHSV-induced IGF2 and oHSV-triggered neutrophil infiltration and NET in BCBM, and characterize the preclinical therapeutic impact of novel IGF2- scavenging oHSV in combination with radiation therapy as well as NET-mitigating oHSV for significant advance of BCBM treatment in the future clinical application.

PI_NAMEs: YOO, JI YOUNG  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Acceleration;Actins;Acyclovir;Address;advanced breast cancer;anti-tumor immune response;Anti-viral resistance;Breast Cancer Patient;cancer cell;Cancer Patient;cancer type;Clinical;clinical application;Clinical Data;Complex;cytotoxic;Development;Diagnostic Imaging;extracellular;FDA approved;Future;Generations;Glioblastoma;Goals;Hyperactivity;Immune Evasion;Immunity;immunotherapeutic virotherapy;Immunotherapy;improved;In Vitro;in vivo;Incidence;Infiltration;Inflammatory;inhibitor;Injectable;Insulin-Like Growth Factor II;Intervention;Japan;Lymphocyte;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Melanoma;Metastatic malignant neoplasm to brain;Microglia;Modality;Modeling;Mus;neoplastic cell;neutrophil;Neutrophil Infiltration;novel;novel therapeutic intervention;oncolytic herpes simplex virus;Outcome;Patients;pre-clinical;pre-clinical assessment;preclinical efficacy;prevent;Quality of life;Radiation therapy;Research;Resistance;resistance mechanism;response;Role;Safety;Signal Pathway;Survival Rate;synergism;Systemic Therapy;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Time;Translations;Treatment Efficacy;tumor;tumor heterogeneity;Tumor Immunity;tumor microenvironment;tumor progression;tumor-immune system interactions;Viral;Virotherapy;Virus;Virus Replication

PROJECT_TITLE: Enhanced Viro-Immunotherapy for Breast Cancer Brain Metastasis


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Narrative In this proposal, we will characterize the trajectories of outcome in early course psychotic disorders treated in coordinated specialty care programs. We will also identify clinical and biological features, and biological subtypes of psychotic disorders that may help predict outcome.

PI_NAMEs: KEEDY, SARAH K;KEEDY, SARAH K (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Accounting;Age Years;Biological;Biological Markers;biomarker development;biomarker identification;biotypes;Bipolar Disorder;Boston;care outcomes;care systems;Categories;Chronic;Clinic;Clinical;clinical practice;clinical predictors;Cognition;Cognitive;cognitive function;Communities;community setting;Coordinated Specialty Care;cost;Data;Data Collection;design;Diagnosis;Diagnostic;Dimensions;Disease remission;early detection biomarkers;Early Intervention;early psychosis;early satiety;Electroencephalography;Enrollment;Eye Movements;follow-up;functional decline;functional outcomes;Funding;Goals;Grant;Heterogeneity;Image;imaging biomarker;Impaired cognition;Impairment;improved;improved outcome;Individual;individual variation;Intervention;Measures;medical specialties;meetings;Modeling;Multivariate Analysis;Neurobiology;Neurocognition;Neurocognitive;neuroimaging;Neurosciences Research;Onset of illness;Outcome;outcome prediction;Participant;Patients;pharmacologic;Phenotype;phenotypic biomarker;Population;Population Characteristics;prediction algorithm;Predictive Value;Procedures;prognostic value;programs;Psychoses;psychosocial;psychotic;Psychotic Disorders;Recovery;recruit;Resources;response;Sampling;Schizoaffective Disorders;Schizophrenia;Schizophreniform Disorder;Services;Site;Stimulus;Structure;Subgroup;Substance abuse problem;success;Testing;Therapeutic Intervention;therapy resistant;Time;treatment adherence;treatment planning;treatment program;Variant

PROJECT_TITLE: 2/5 Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(60)-C]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: STILLWATER

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

PHR: PROJECT NARRATIVE  The proposed fast-tracking ML-CFD-DEM based reduced order model (ROM) will surpass existing CFD-based in silico tool by enabling the predictions of (1) the influence of disease-specific airway deformation kinematics on the transport and deposition of inhaled dry powder particles in the whole lung, (2) the particle-particle and particle-wall interactions along with the emitted APSDs from dry powder inhalers. With the abovementioned advantages, the proposed ROM is relevant to GDUFA III initiatives, to (1) significantly enhance the computational efficiency of in silico approach for BE evaluation between generic and reference listed complex drug-device combination products with uncertainty quantification, and (2) explore the capability of AI/ML tools to facilitate regulatory assessments with the statistical robustness of the OIDP performance. Accordingly, the proposed synergistic research is relevant to public health since it will speed up the delivery of safe and effective generic OIDPs to the public by enhancing the understanding of how disease-specific lung features, DPI design, drug formulation, and patient-device coordination can influence the drug delivery efficacy to peripheral lung to treat COPD.

PI_NAMEs: CAI, CHANGJIE ;FENG, YU  (contact);LIU, CHENANG ;WU, HUIMIN

PROGRAM_OFFICER_NAME: WALENGA, ROSS

PROJECT_TITLE: ML-CFD-DEM Based Reduced Order Models (ROM) to Quantify Variability in Inhalers, Drugs, and Users for Evaluating Comparability of Generic OIDP Complex Products

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDER-T (02)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: MADISON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative This bioethics supplement proposes to conduct a normative and empiric evaluation of health equity and justice as it relates to somatic cell gene editing for inherited retinal disorders (IRDs). The proposal outcomes will increase bioethics capacity in the Somatic Cell Gene Editing consortium by producing a normative review of health equity issues in gene editing and synthesizing the grant experience in a ‘Meet the experts’ presentation. The proposal will also gather data from up to 30 individuals with lived experience of IRD on relevant issues towards research ethics and health equity for somatic cell gene editing.

PI_NAMEs: SAHA, KRISHANU  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Address;Area;Attention;Attitude;Basic Science;Benefits and Risks;Bioethics;Books;Clinic;Clinical;clinical application;clinical practice;clinical translation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Code;community engagement;Data;Data Collection;Development;Disease;Eligibility Determination;Epidemiology;Equity;Ethical Issues;Ethics;Evaluation;experience;Eye;Family;Family member;Foundations;Frequencies;Funding;Future;gene-editing approach;Genes;genetic testing;Genetic Transcription;genome editing;genome editor;Germ Lines;Goals;Grant;health disparity;health equity;Individual;Informed Consent;Inherited;Interview;Justice;Lived experience;Medical;Medical Technology;Mutation;Nature;Outcome;Outcome Measure;parent grant;Parents;Participant;Pathway interactions;patient engagement;Patients;Persons;Phase;Positioning Attribute;Process;programs;Quality of life;Research;Research Ethics;Research Personnel;Retina;Retinal Diseases;Review Literature;Shapes;social;Somatic Cell;somatic cell gene editing;Spanish;Spanish/English;Technology;Testing;therapeutic genome editing;Translating;Translations;United States National Institutes of Health;Universities;uptake;Vision;Visual impairment;Wisconsin;Work

PROJECT_TITLE: Health equity in the development of somatic cell genome editors for retinal disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative:  Axons connect neurons to their targets and enable information transfer. In many neurodegenerative diseases, axon loss is an early event contributing to dysfunction of the nervous system. We recently identified STMN2 as an important protein for the maintenance of axons. Since loss of STMN2 occurs in Alzheimer's Disease and ALS, it is important to understand how STMN2 contributes to the survival of axons. Here we will define the role of STMN2 for axon maintenance in both the healthy and diseased nervous system. These new insights could lead to methods to maintain axons and treat neurodegenerative diseases.

PI_NAMEs: DIANTONIO, AARON  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: ALS pathology;ALS patients;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Animal Model;Apoptotic;Axon;axon injury;axon regeneration;axonal degeneration;Axonal Transport;Axotomy;Binding;Biochemical;Biological Markers;Biological Models;cell type;Cells;Collaborations;conditional knockout;Data;Degenerative Disorder;Dementia;dimer;Disease;Dissection;Down-Regulation;Drops;Event;experimental study;Family member;fast axonal transport;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Funding;gain of function;Genes;Health;Human;human induced pluripotent stem cells;In Vitro;in vivo;in vivo evaluation;in vivo Model;Injury;insight;Knockout Mice;Knowledge;loss of function;Maintenance;Messenger RNA;Methods;Microtubules;mitochondrial dysfunction;Modeling;Molecular;Motor Neuron Disease;mouse model;Nerve Degeneration;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;neuron loss;Neuronal Dysfunction;Neurons;Orthologous Gene;Paper;Pathologic;Pathology;Pathway interactions;Patients;Phosphotransferases;Productivity;protein degradation;protein TDP-43;Proteins;Regulation;response to injury;RNA Splicing;Role;Signal Transduction;Spinal Cord;stathmin;stress kinase;Testing;therapeutic candidate;therapeutic target;Transcript;Tubulin;vesicle transport;Work

PROJECT_TITLE: Regulation of axonal degeneration by the DLK kinase


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: NARRATIVE The Rhode Island Child Health Study (RICHS) cohort provides a unique and innovative birth cohort resource focused on the fundamental role of the placenta in the programming of children’s health and disease risk by the prenatal environment. During the prior funding period, cohort resources and investigators have made semi- nal contributions to children’s environmental health and to training the next generation of environmental health scholars. Infrastructure support for sustaining the cohort will support new longitudinal assessments within this extensively characterized resource, enrichment of data management and sharing activities, and new efforts to diversify the participants, measures, and workforce for the cohort—all serving the ultimate goal of catalyzing transformative environmental health research by strengthening and diversifying the scientific workforce.

PI_NAMEs: MARSIT, CARMEN JOSEPH (contact);STROUD, LAURA R

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Acceleration;Age;Ancillary Study;Attention;Behavioral;biobank;Birth;career;Chemicals;Child;Child Health;cohort;Cohort Studies;Collaborations;Collection;Communities;critical period;Data;data management;data sharing;deprivation;Development;Disease;Disease Outcome;disorder risk;Diverse Workforce;early childhood;Enrollment;Environment;Environmental Exposure;Environmental Health;Environmental Impact;Epidemiology;Epigenetic Process;Exposure to;Fellowship;follow-up;Funding;Future;Genomics;Goals;Grant;Growth;Health;Infant;Infrastructure;innovation;Investments;K-Series Research Career Programs;Link;Massachusetts;Measures;Mediating;method development;Molecular;Molecular Biology;Mothers;National Institute of Environmental Health Sciences;Neighborhoods;neurobehavioral;Newborn Infant;next generation;novel;offspring;Outcome;parent grant;Participant;Placenta;Placental Biology;population based;postnatal;Pregnancy;prenatal;prenatal exposure;Problem behavior;Productivity;prospective;Psychopathology;Publications;R24;recruit;Regulation;Research;Research Personnel;Resources;Rhode Island;Role;Sampling;Scientist;Seminal;social;social determinants;social health determinants;social structure;Stimulus;structural determinants;Structural Racism;Symptoms;System;Training;Underrepresented Populations;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Enriching the Rhode Island Child Health Study


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Rehabilitation

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: There is an urgent need to develop interventions that will delay functional disability and improve the quality of life of our growing aging population. This work is expected to lead to a scalable compensation and lifestyle intervention to improve well-being and delay disability in individuals at risk for Alzheimer’s disease and other disorders. This research is relevant to public health and NIH’s mission as the results are expected to have an important positive impact on caregiver burden, health care costs and the functional independence of our aging population.

PI_NAMEs: SCHMITTER-EDGECOMBE, MAUREEN ;TOMASZEWSKI-FARIAS, SARAH E (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: Activities of Daily Living;Adherence;Adoption;aging population;Alzheimer's Disease;Alzheimer's disease risk;Behavior monitoring;Behavior Therapy;Behavioral;brain health;Calendar;Caregiver Burden;Characteristics;Cognition;Cognitive;Collection;Compensation;Control Groups;Data;dementia risk;design;digital;digital applications;digital tool;disability;Disease;Education;Educational Materials;Encapsulated;ethnoracial;executive function;Exercise;Feedback;Friends;functional disability;functional improvement;functional independence;Goals;Health behavior;Health Care Costs;Health Status;healthy aging;improved;Individual;innovation;instrumental activity of daily living;Intervention;Life Style;Life Style Modification;lifestyle intervention;machine learning algorithm;Medical;Memory;Methods;mild cognitive impairment;Mission;modifiable risk;Monitor;Motivation;novel;older adult;Outcome;Participant;Pattern;Personal Satisfaction;Physical Function;Population Heterogeneity;Populations at Risk;Prevalence;prevent;preventive intervention;primary outcome;promote resilience;Public Health;Quality of life;Randomized, Controlled Trials;Research;secondary outcome;stress management;Symptoms;System;Testing;Time;tool;Training;treatment adherence;Treatment Efficacy;treatment responders;United States National Institutes of Health;Work

PROJECT_TITLE: Compensation Training and Lifestyle Modifications to promote healthy aging in persons at risk for Alzheimer's disease: a digital application supported intervention


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Stomach Cancer

ORG_DEPT: BIOCHEMISTRY

PHR: OVERALL NARRATIVE The University of California and University of Texas Southwestern Diversity Patient-Derived Xenograft Development and Trial Center takes advantage of the collective strengths of six NCI-Comprehensive Cancer Centers to create minority patient cancer models and characterize targeted treatment responses to stomach and lung tumors. The impact of this collaborative is to understand the biological processes involved in cancer health disparities and to develop new effective treatments in patient-derived models to translate into clinical trials.

PI_NAMEs: CARVAJAL CARMONA, LUIS GUILLERMO (contact);RIESS, JONATHAN W

PROJECT_TERMS: Advanced Malignant Neoplasm;Affect;ARID1A gene;Asian ancestry;Asian population;Asian Women;Bioinformatics;Biological;Biological Process;California;Cancer Biology;Cancer Center;cancer health disparity;Cancer Model;cancer subtypes;Cancer Therapy Evaluation Program;Catchment Area;Cause of Death;Cell Cycle;Cells;Clinical;Clinical Trials;Collection;Combination Drug Therapy;Combined Modality Therapy;comparative;Complex;Comprehensive Cancer Center;Data;Decision Making;Development;Digit structure;Disease;Disparity;Drug Combinations;effective therapy;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;ethnic diversity;ethnic minority;expectation;Family;FDA approved;FRAP1 gene;Frequencies;Genetic;Genome;Genomics;Goals;Grant;Health Disparities Research;health equity;Implant;Indigenous American;Infrastructure;Latina Population;Latino;Latino Population;Light;Los Angeles;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;malignant stomach neoplasm;member;Minority;Minority Groups;minority patient;Modeling;Molecular;Molecular Abnormality;molecular subtypes;mortality;mortality disparity;multidisciplinary;mutant;Mutate;Mutation;never smoker;new therapeutic target;novel;Oncogenes;Pathway interactions;patient derived xenograft model;Patient Isolation;Patients;people of color;Pharmaceutical Preparations;Phosphotransferases;PI3K/AKT;Pilot Projects;Population;Population Heterogeneity;Pre-Clinical Model;Precision Health;precision oncology;Precision therapeutics;Preclinical Drug Development;Preclinical Testing;Process;Productivity;Publishing;racial diversity;racial minority;Regimen;Research;Research Personnel;Research Project Grants;Resistance;resistance mechanism;Resources;response;response biomarker;Risk Factors;Role;San Francisco;Signal Transduction;Site;Smoking;Smoking History;Solid;Stomach;Stomach Neoplasms;targeted cancer therapy;targeted treatment;Testing;Texas;therapeutically effective;Time;Translating;treatment response;tumor;tumor diagnosis;tumorigenesis;Underrepresented Minority;Universities;women patients;women's diagnosis;Work

PROJECT_TITLE: The role of ARID1A mutations in Latino gastric cancer biology and disparities


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Evidence on best treatment and prevention options for pregnant people is essential for global guidelines and clinical practice, but pregnant people are generally excluded from research. This proposal aims is to support formative research on barriers to the inclusion of pregnant people in tuberculosis clinical trials with the aim of improving research equity.

PI_NAMEs: CHAISSON, RICHARD E.;KARAKOUSIS, PETROS C (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Address;Advisory Committees;Advocacy;Affect;Age;Attitude;Bioethics;child bearing;Clinical;clinical practice;Clinical Trials;Collaborations;Communicable Diseases;Communities;community engagement;Consensus;Country;Data;design;Development;efficacy evaluation;Equity;Ethicists;Ethics;Exclusion;experience;falls;Fostering;Funding;Future;Goals;Guidelines;HIV;improved;Individual;Industry;informant;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;Interview;Lactation;meeting reports;meetings;member;Methods;Mission;National Institute of Allergy and Infectious Disease;novel therapeutics;novel vaccines;outreach;Participant;Perception;Persons;Phase;Policies;Policy Maker;pregnant;Pregnant Women;Prevention;Prevention strategy;preventive intervention;Preventive therapy;Preventive vaccine;Principal Investigator;Productivity;Protocols documentation;Publishing;Questionnaires;Recommendation;Research;Research Design;Research Personnel;response;Safety;Structure;support network;Surveys;Technology;Therapeutic;therapeutic vaccine;Training;Tuberculosis;United States National Institutes of Health;uptake;USAID;Vaccines;Woman;Work;World Health Organization

PROJECT_TITLE: Ethics of Including Pregnant People in Clinical Trials


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Pediatric

PHR: Project Narrative Developmental Language Disorder affects approximately seven percent of the population and is characterized by grammatical deficits that cascade into lifelong academic challenges and under-employment. Current treatments for DLD produce good outcomes under ideal, high intensity conditions or when parents have been trained to deliver therapy using intense coaching methods; however, current publicly funded service delivery systems and private-pay reimbursement models do not support treatment being delivered in this ideal fashion for children older than three. This project will examine alternative methods of delivering treatment that may be more feasible under typical conditions and will identify implementation barriers, with the goal of improving long- term outcomes for children with DLD.

PI_NAMEs: VAN HORNE, AMANDA JEAN OWEN (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Adherence;Adopted;Adoption;Adult;Advocate;Affect;Age;alternative treatment;Behavior;Books;caregiver education;Caregivers;Characteristics;Child;Childhood;comparative efficacy;Complex;Comprehension;comprehension deficit;cost;Data;design;Development;Disease;Dose;Educational Curriculum;Effectiveness;Enrollment;Equation;Exposure to;Feedback;Funding;Future;Goals;Home;implementation barriers;improved;Individual;interactive feedback;Intervention;Knowledge;Laboratories;Language Development;Language Development Disorders;Laws;Learning;Learning Difficulty;literacy;Methods;Modeling;Nature;Outcome;parenting intervention;Parents;Pattern;Population;Privatization;Production;Provider;Quality of life;Randomized, Controlled Trials;Reader;Reading;Recommendation;remediation;Reporting;Risk;Role;scale up;School-Age Population;service delivery;Service delivery model;Service provision;skills;Speech;Speech Pathologist;standard of care;Structure;success;syntax;System;Techniques;Theoretical Domains framework;Training;Underemployment;visual tracking;Width;Work

PROJECT_TITLE: Recasting and book reading under ideal (dose-controlled) and typical (dose-variable) conditions: The role of fidelity and adherence in production and comprehension outcomes for children with DLD

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_DEPT: PHARMACOLOGY

ORG_NAME: TEXAS SOUTHERN UNIVERSITY

PHR: RCMI - DATABIOM: RCMI Data Analytics and Training for Bioinformatics, Machine Learning in Health Research Public Health Relevance Statement This project aims to bolster the institutional data science capacity at TSU and foster close collaboration between researchers from TSU and our partner institution in data science field. Additionally, it seeks to increase the involvement and representation of underserved and minority populations in biomedical computing and information disciplines. As a part of the TMC institution, the project will leverage data science education, training, and partnerships to empower TSU to make substantial contributions towards understanding health disparities, enhancing health outcomes, and significantly improving the representation of underrepresented populations in computing degrees. The integration of data analytics, bioinformatics, and machine learning is crucial for revolutionizing global public health through advancements in precision medicine and the optimization of interventions for diverse populations.

PI_NAMEs: LIANG, DONG ;OLALEYE, OMONIKE ARIKE (contact);XIE, HUAN

PROGRAM_OFFICER_NAME: GARRIDO, CARLOS OSWALDO

PROJECT_TERMS: Address;Admission activity;advanced analytics;Advocate;African American population;Algorithms;Artificial Intelligence;Bioinformatics;Biomedical Computing;biomedical informatics;Cities;Clinical;Collaborations;Communities;Competence;cost effective;Data;Data Analyses;Data Analytics;data infrastructure;data integration;data management;data modeling;Data Science;data science education;Data Set;data visualization;Discipline;disease diagnosis;diverse data;drug development;drug discovery;Educational Curriculum;Employment;empowerment;Environment;Equity;Faculty;FAIR principles;forging;Fostering;Genomics;Goals;Growth;Health;Health Care Research;health disparity;Healthcare;Historically Black Colleges and Universities;human capital;improved;Industry;innovation;Institution;Intervention;Machine Learning;medically underserved;Minority Groups;Minority-Serving Institution;Monitor;Outcome;Patient-Focused Outcomes;pharmacologic;Population;Population Heterogeneity;Postdoctoral Fellow;precision medicine;Preventive;programs;Public Health;Public Health Informatics;public health relevance;public health research;rapid growth;Research;Research Personnel;skills;Students;Techniques;Texas;tool;Training;Training and Education;Training Programs;Translating;undergraduate student;Underrepresented Populations;Underrepresented Students;underserved community;Underserved Population;United States;Universities

PROJECT_TITLE: RCMI - DATABIO: RCMI Data Analytics and Training for Bioinformatics, Machine Learning, and Health Disparity in Texas Southern University


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Infectious Diseases

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE  Streptococcus gallolyticus subsp. gallolyticus (Sgg) is an opportunistic human pathogen that is implicated in life-threatening diseases including bacteremia, infective endocarditis, and colorectal cancer. This proposal aims to investigate a novel and critical virulence mechanism to gain a better understanding of how Sgg causes diseases.

PI_NAMEs: XU, YI  (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Animal Model;Antibodies;Area;Bacteremia;Biological;Cancerous;career development;cell behavior;Cell Culture Techniques;Cell model;Cell surface;Cell Surface Receptors;cell type;Cells;Clinical;Colon;Colonic Neoplasms;Colorectal Cancer;cytokine;Disease;Endothelial Cells;Ensure;Epidermal Growth Factor Receptor;Epithelial Cells;Epithelium;Exposure to;Future;genome analysis;Genotype;Goals;Graduate Education;graduate student;Growth Factor Receptors;Homeostasis;human pathogen;Immune response;immunoreaction;immunoregulation;In Vitro;Infective endocarditis;Investigation;Knowledge;Life;Ligands;Macrophage;Mediating;Mentors;Mentorship;microbial;Molecular;Mus;mutant;Nitric Oxide;novel;Outcome;parent grant;Parents;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Phagocytosis;Phenotype;Play;Production;Proteins;Reactive Oxygen Species;Recombinants;Regulation;Research;Research Personnel;Role;Signal Transduction;skills;Stimulation of Cell Proliferation;Streptococcus;Students;System;Training;trait;tumor growth;Underrepresented Populations;Underrepresented Students;Virulence

PROJECT_TITLE: Diversity Supplement:  Type VII secretion in Streptococcus gallolyticus pathogenesis


NIH_SPENDING_CATS: Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Narrative (Parent Grant: 1R01AI174181) Many skin diseases such as inflammatory diseases are due to the dysregulated immune homeostasis in the skin. Understanding how the immune system in the skin is regulated is fundamental to understand the basis of immune homeostasis and inflammation in the skin, the largest barrier tissue of a body under frequent assaults of various environmental factors. Findings from our proposed study on regulation of skin-specific migration and localization of various innate-like T lymphocytes will aid our understanding of molecular mechanisms regulating the skin immune response and development of therapeutic targets in treatment of the skin inflammation diseases.

PI_NAMEs: XIONG, NA  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Address;Adult;Age;Applications Grants;assault;B-Lymphocytes;Birth;Cells;design;Development;Developmental Process;Disease;Environment;environmental agent;Environmental Risk Factor;Epithelium;Equilibrium;Exposure to;fetal;Fetal Liver;Generations;Goals;Health;Hematopoietic stem cells;Homeostasis;Homing;Immune;immune function;Immune response;Immune system;In Transferrin;Individual;Infant;Inflammation;Inflammatory;Iron;iron metabolism;Maintenance;migration;Molecular;Morphogenesis;Mucous Membrane;Nutrient;parent grant;Play;postnatal;Property;Publishing;Regulation;Role;Skin;skin disorder;Skin Tissue;Source;stem cells;T-Cell Development;T-Lymphocyte;Testing;Therapeutic;therapeutic development;therapeutic target;Thymus Gland;Time;Tissues;Transferrin;γδ T cells

PROJECT_TITLE: Development and function of skin-resident innate-like T cells at early postnatal stages


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Lung;Lung Cancer

PHR: Parent Award - PROJECT NARRATIVE Although early stage colorectal cancer (CRC) is curable (with surgery and adjuvant therapy) metastatic colon cancer is usually lethal. Therefore, our proposal focuses on understanding the regulatory mechanism of a lncRNA our lab discovered to promote oncogenic phenotypes and treatment resistance through its interactions with protein-coding genes. Further, we will address the current lack of reliable biomarkers to assess clinical outcome by investigating whether this lncRNA can be used to determine which localized CRC tumors are likely to progress and metastasize.

PI_NAMEs: FIELDS, RYAN C;MAHER, CHRISTOPHER A (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Address;Adjuvant Therapy;Biological Markers;Cancer Patient;cancer therapy;Chemoresistance;Clinical;clinical outcome assessment;Code;cohort;colon cancer patients;Colon Carcinoma;Colorectal Cancer;colorectal cancer progression;Data;differential expression;Disease;Disease-Free Survival;Distant;DNA topoisomerase II alpha;Epigenetic Process;epigenetic regulation;Epithelial Cells;experimental study;GCLC gene;GCLM gene;Gene Expression Regulation;Genes;Genetic Transcription;Goals;high risk;Human Resources;In Vitro;in vivo;insight;Large-Scale Sequencing;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Meta-Analysis;metastatic colorectal;Metastatic/Recurrent;Methods;Modality;Molecular;molecular phenotype;mutant;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;NOTCH3 gene;novel;NQO1 gene;Nuclear;Oncogenic;Operative Surgical Procedures;parent project;Parents;Patients;Phenotype;Primary Neoplasm;programs;Proteins;recruit;Regulation;Research;Research Project Grants;Research Support;RNA;Role;Sampling;therapy resistant;Tissues;Transcriptional Regulation;transcriptome sequencing;translational impact;tumor;Tumor Biology

PROJECT_TITLE: The role of RAMS11 in colorectal cancer progression and treatment resistance

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The proposed mechanistic trial will utilize mindfulness training to permit examination of questions about the causal role of emotion regulation strategies linked to the striving persistent behavioral style in driving mental health and health morbidities among BIPOC78. The proposed Project STRIVE (STudents RIsing aboVE) will identify BIPOC students who are academically resilient in the face of disadvantage and will offer a tailored mindfulness intervention targeting self-regulation processes as a putative mechanism to interrupt the links between the striving persistent behavioral style and negative health outcomes. We propose a multisite randomized trial to the effects of the STRIVE intervention on putative self-regulation mechanisms, health and mental health outcomes, and to examine the mechanistic model linking striving persistent behavioral style to health and mental health morbidities.

PI_NAMEs: LAU, ANNA SHAN-LAI (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Academic achievement;Aftercare;allostatic load;anxiety symptoms;Asian Americans;attentional control;Automobile Driving;Behavioral;Biological Markers;Black race;Black, Indigenous, People of Color;Blood Pressure;Body mass index;children of color;Chronic stress;cost;depressive symptoms;Disadvantaged;emotion regulation;Emotions;examination questions;Exhibits;Health;Health Care Costs;health disparity;Hip region structure;Hydrocortisone;Informal Social Control;Interruption;Intervention;Latinx;Link;marginalized community;Mental Health;mindfulness intervention;Mindfulness Training;Modeling;Morbidity - disease rate;Neck;Outcome;physical conditioning;Physiological;Population;prevent;preventive intervention;Process;Randomized;randomized trial;Research;resilience;Role;Schools;Site;skills;socioeconomic disadvantage;Students;Study Skills;success;Symptoms;Testing;Youth

PROJECT_TITLE: Project STRIVE (STudents RIsing above) - Offsetting the health and mental health costs of resilience

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: BIOLOGY

PHR: Project Narrative A project narrative is not required for this Diversity Supplement.

PI_NAMEs: HORNBERGER, TROY A (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Instruction;mechanical drive;Research;skeletal muscle growth

PROJECT_TITLE: Identifying the Structural Adaptations that Drive the Mechanically Induced Growth of Skeletal Muscle

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Prostate Cancer;Urologic Diseases

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: NARRATIVE Men with metastatic castration sensitive prostate cancer (mCSPC) are at high risk of disease progression and while the treatments used can delay progression, they can increase the risk of metabolic side effects (diabetes and heart disease), therefore, data from our team has shown that intermittent fasting using a fasting mimicking diet (FMD) can improve metabolic health in people and delay cancer progression in mice, including in prostate cancer models. Our parent R01 proposes a phase 2 multisite randomized trial of intermittent fasting with a FMD versus standard of care in men with mCSPC designed to improve cancer control and reduce risk of diabetes, while gaining insight into how insulin and IGF1 signaling are associated with the benefit of FMD in delaying prostate cancer progression. Our proposed supplement seeks to conduct observational studies to explore the link between differential dietary patterns and PCa risk in multiethnic cohorts.

PI_NAMEs: DORFF, TANYA ;FREEDLAND, STEPHEN JAY (contact);LIN, PAO-HWA

PROGRAM_OFFICER_NAME: KIM, YOUNG S

PROJECT_TERMS: Adherence;Affect;androgen deprivation therapy;Androgen Receptor;anti-cancer research;Biological;Biological Markers;black patient;blood pressure regulation;Calories;Cancer Control;cancer diagnosis;Cancer Patient;cancer risk;Cancer Survivor;Carbohydrates;carcinogenesis;cardiovascular risk factor;Castrate sensitive prostate cancer;Castration;Cell Proliferation;Cessation of life;chemotherapy;Clinical;Clinical Nutrition;Clinical Research;Code;cohort;Communities;comorbidity;Comparative Study;Consumption;Data;design;Development;Diabetes Mellitus;diabetes risk;Diet;dietary approach;Dietary Practices;Disease Progression;Eating;Edible Plants;Environmental Risk Factor;Enzymes;European;experience;Fasting;Food;food consumption;Fruit;Genes;Genetic;Glucose;Guidelines;Health;Heart Diseases;high risk;high risk men;Hormonal;Human;Hyperglycemia;IGF1 gene;improved;Income;Inflammation;insight;Insulin;Insulin Resistance;insulin sensitivity;Insulin-Like Growth-Factor-Binding Proteins;interest;Intermittent fasting;Intervention;Leptin;Link;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medical center;Mediterranean Diet;men;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolic syndrome;Metabolism;metabolome;metabolomics;Metastatic Prostate Cancer;Molecular;molecular subtypes;Morbidity - disease rate;mortality;mouse model;multi-ethnic;Mus;Neoplasm Metastasis;next generation;Nuts;Obesity;Observational Study;Outcome;Parents;Pathway interactions;Patients;Persons;Phase;Plants;Play;Population;prevent;Process;prostate cancer model;prostate cancer progression;prostate cancer risk;Proteins;randomized trial;Randomized, Controlled Trials;Research;research study;Resistance;Risk;Risk Factors;Risk Reduction;Role;Sampling;saturated fat;side effect;Signal Transduction;Site;skeletal;Societies;standard of care;sugar;Survivors;targeted agent;Testing;Time;Toxic effect;Treatment-related toxicity;tumor;tumor progression;Variant;Vegetables;Veterans;western diet

PROJECT_TITLE: A Comparative Study of Risk Factors for Men with and without Prostate Cancer at the VA Medical Center in Durham

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Pediatric;Prevention;Psychosis;Rehabilitation;Schizophrenia;Serious Mental Illness

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative  The proposed study is designed to target processing speed, a cognitive domain related directly to social functioning, which in turn, represents a vulnerability factor for psychosis. We have developed a new remotely-delivered intervention combining targeted cognitive training exercises and group support to directly impact processing speed, and at the same time, boost motivation and engagement in adolescents at risk for schizophrenia and other psychotic disorders.

PI_NAMEs: CARRION, RICARDO ;CORNBLATT, BARBARA A. (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: 20 year old;Adolescent;Adolescent and Young Adult;Age;Antipsychotic Agents;arm;Attenuated;Behavior;Child;Clinical;clinical heterogeneity;clinical high risk for psychosis;Cognitive;Cognitive deficits;Cognitive remediation;cognitive training;Consensus;design;Dose;Early Intervention;Exercise;Future;high risk;high risk population;high-risk adolescents;Hour;improved;improved outcome;Individual;innovation;Internet;Intervention;MATRICS Consensus Cognitive Battery;Measures;Motivation;National Institute of Mental Health;Neuropsychology;novel;Outcome;Patients;Phase;Pilot Projects;Prevention;Preventive;processing speed;Psychoses;psychosis risk;Psychotic Disorders;Randomized;remote delivery;Sampling;Schizophrenia;schizophrenia risk;Social Functioning;study population;Support Groups;Symptoms;Teenagers;Testing;Time;Training;Youth

PROJECT_TITLE: 04S1: Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk in Adolescents at Clinical High Risk for Psychosis


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative N/A

PI_NAMEs: MOFFITT, ANDREA  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TITLE: Measuring treatment response and residual disease in leukemia with personalized, sensitive, and quantitative genomic methods

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Cancer;Liver Disease;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: In the United States, HCC is one of the fastest growing causes of cancer related death with a 5- year survival of less than 12%. Notably, this disease burden is disproportionately expressed among different demographic ethnic groups as the incidence and mortality rates in the US are about three times as high in Hispanics as in non-Hispanic whites in both genders. Our research is expected to generate a mechanistic linkage among the mitochondrial genotype, HCV infection, mitochondrial function and tumorigenesis in HCC, a disease that is over-represented in the Hispanic population.

PI_NAMEs: BAI, YIDONG  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Alcohol consumption;Big Data;biobank;Bioinformatics;Biological Models;burden of illness;Cancer Etiology;cancer type;Cell model;Cells;Cessation of life;Cirrhosis;Complement;Complex;Data;Databases;Death Rate;Development;Disease;dosage;epidemiology study;Ethnic Origin;Ethnic Population;Exhibits;Functional disorder;Gender;Gene Expression;Generations;Genetic;Genetic Polymorphism;genetic risk factor;Genotype;Haplogroup;health disparity;Hepatitis B Virus;Hepatitis C;Hepatitis C virus;hepatocellular carcinoma cell line;High Prevalence;high risk;Hispanic;Hispanic Populations;Human;Incidence;inducible gene expression;Inpatients;Investigation;Liver;Mediating;Metabolic Diseases;Metabolic syndrome;Mitochondria;Mitochondrial DNA;mitochondrial DNA alteration;mitochondrial dysfunction;Molecular;mortality;Mutation;NADH dehydrogenase (ubiquinone);Neoplasm Metastasis;non-alcoholic fatty liver disease;Not Hispanic or Latino;novel;Nuclear;Obesity;Oxidative Stress;Pathologic;Pathway interactions;Patients;Physiological;Play;Population;Positioning Attribute;Prevention;Primary carcinoma of the liver cells;Procedures;protein expression;Proteins;public database;Regulation;Reporting;Research;Rest;Risk Factors;Role;Sampling;South Texas;success;System;Technology;Testing;Time;Tissue Sample;Tissues;transplant centers;tumorigenesis;United States;Viral Proteins;Virus Diseases

PROJECT_TITLE: The mitochondrial aspects of health disparity of hepatocellular carcinoma in Hispanic population

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: EB

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: PROJECT NARRATIVE This research will explore the ethical concerns arising from using black-box AI models for stratifying newly diagnosed breast cancer patients for genetic mutation and communicating test results. We will investigate how generating the explainability of AI models and managing bias could mitigate these challenges. Subsequently, we will analyze different methods for generating explanations that are favorable to medical practitioners in effectively communicating AI-based decisions to patients.

PI_NAMEs: IQUEBAL, ASHIF  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: accurate diagnosis;Adjuvant Therapy;Administrative Supplement;artificial intelligence method;artificial intelligence model;Bioethics;Black Box;BRCA mutations;Breast Cancer Detection;Breast Cancer Patient;Clinical Decision Support Systems;clinical decision-making;Communication;Data;Decision Making;Disparity;DNA Sequence Alteration;Early Diagnosis;Effectiveness;Eligibility Determination;Ethics;Ethnic Population;explainable artificial intelligence;Family;follow-up;frontier;Future;Genetic Screening;genetic testing;Germ Lines;Goals;Guidelines;health care disparity;Health Technology;Healthcare Systems;Image;improved;Intervention;Low Income Population;Malignant Breast Neoplasm;Medical;Medical Imaging;Methods;Modeling;National Comprehensive Cancer Network;Newly Diagnosed;Operative Surgical Procedures;parent project;Pathogenicity;Patient Care;patient screening;Patient-Focused Outcomes;Patients;Phenotype;Policies;Populations at Risk;Predictive Value;racial population;Recommendation;Recording of previous events;Research;Review Literature;Risk Factors;Test Result;Testing;treatment strategy;Trust;Woman

PROJECT_TITLE: Navigating Ethical Frontiers of AI-Driven Clinical Decision Support Systems: Exploring Explainability and Bias


ORG_DEPT: MISCELLANEOUS

ORG_NAME: NORTHEASTERN ILLINOIS UNIVERSITY

PHR: The relevance of the proposed data science supplement to public health is within the scope of the parent U54 ChicagoCHEC partnership. Specifically, this research will contribute to fundamental knowledge involving data science and cancer health-disparities to further enhance health, lengthen life, and reduce illness and disability of cancer patients in Chicago-land area and beyond.

PI_NAMEs: CIECIERSKI, CHRISTINA  (contact);FEINGLASS, JOSEPH M;FILUS, LIDIA ;FITZGIBBON, MARIAN L.;JIMBO, MASAHITO ;SIMON, MELISSA A.

PROGRAM_OFFICER_NAME: SAN MIGUEL-MAJORS, SANDRA L

PROJECT_TERMS: Adopted;Advanced Malignant Neoplasm;anti-cancer research;Area;cancer health disparity;Cancer health equity;Cancer Patient;Chicago;Community Outreach;Complement;Comprehensive Cancer Center;Data Science;data science resource;Dedications;Development;disability;Education;Education and Outreach;education research;Educational Activities;Educational Curriculum;Educational workshop;Evaluation;Faculty;forging;Funding;Goals;graduate student;Health;Hispanic-serving Institution;Illinois;innovation;Institution;Knowledge;Learning;Life;Malignant Neoplasms;metropolitan;Minority-Serving Institution;Multicultural Education;outreach;Parents;programs;Public Health;Research;Research Activity;Research Project Grants;Schools;Science;tool;Training;undergraduate student;underserved community;Universities

PROJECT_TITLE: The Chicago Cancer Health Equity Collaborative (ChicagoCHEC)


NIH_SPENDING_CATS: Cancer;Radiation Oncology

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

PHR: Project Narrative This diversity supplement to 5 R01 CA266879-02 will provide funding for UI post-baccalaureate student Daniel Robles to conduct research as part of the parent grant, pursuing a goal of being admitted to medical school, becoming an independent physician scientist in radiation oncology and entering the cancer workforce.

PI_NAMEs: HOLMES, JAMES H (contact);WELLS, SHANE A;YEO, DESMOND TECK BENG

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Admission activity;Funding;Goals;Malignant Neoplasms;medical schools;parent grant;Parents;Physicians;Postbaccalaureate;Radiation Oncology;Research;Scientist;Students

PROJECT_TITLE: Diversity Supplement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(57)-R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Stomach Cancer

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Advanced Malignant Neoplasm;Affect;Asian ancestry;Asian population;Asian Women;Bioinformatics;Biological;Biological Process;California;Cancer Biology;Cancer Center;cancer health disparity;Cancer Model;cancer subtypes;Cancer Therapy Evaluation Program;Catchment Area;Cause of Death;Cell Cycle;Cells;Clinical;Clinical Trials;Collection;Combination Drug Therapy;Combined Modality Therapy;comparative;Complex;Comprehensive Cancer Center;Data;Decision Making;Development;Digit structure;Disease;Disparity;Drug Combinations;effective therapy;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;ethnic diversity;ethnic minority;expectation;Family;FDA approved;FRAP1 gene;Frequencies;Genetic;Genome;Genomics;Goals;Grant;Health Disparities Research;health equity;Implant;Indigenous American;Infrastructure;Latina Population;Latino;Latino Population;Light;Los Angeles;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;malignant stomach neoplasm;member;Minority;Minority Groups;minority patient;Modeling;Molecular;Molecular Abnormality;molecular subtypes;mortality;mortality disparity;multidisciplinary;mutant;Mutate;Mutation;never smoker;new therapeutic target;novel;Oncogenes;Pathway interactions;patient derived xenograft model;Patient Isolation;Patients;people of color;Pharmaceutical Preparations;Phosphotransferases;PI3K/AKT;Pilot Projects;Population;Population Heterogeneity;Pre-Clinical Model;Precision Health;precision oncology;Precision therapeutics;Preclinical Drug Development;preclinical study;Preclinical Testing;Process;Productivity;Publishing;racial diversity;racial minority;Regimen;Research;Research Personnel;Research Project Grants;Resistance;resistance mechanism;Resources;response;response biomarker;Risk Factors;Role;San Francisco;Signal Transduction;Site;Smoking;Smoking History;Solid;Stomach;Stomach Neoplasms;targeted cancer therapy;targeted treatment;Testing;Texas;therapeutically effective;Time;Translating;treatment response;tumor;tumor diagnosis;tumorigenesis;Underrepresented Minority;Universities;women patients;women's diagnosis;Work

PROJECT_TITLE: Cancer biology and pre-clinical studies of BRCAness in Latino gastric tumors


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Lung

ORG_CITY: TYLER

ORG_NAME: UNIVERSITY OF TEXAS HLTH CTR AT TYLER

PHR: Pleural fibrosis is thickening/stiffening of the pleura resulting from pleural infection, asbestos-related pleural disease, and treatments, etc., which leads to severe restrictive lung disease and clinically significant dyspnea associated with fibrothorax. We have identified a gene called Dedicator of Cytokinesis 2 (DOCK2) that plays a key role in mesothelial to mesenchymal transition and pleural fibrosis. The proposed studies will shed new lights on the pathogenesis of pleural fibrosis and may ultimately lead to the identification of novel targets for therapeutic intervention of this detrimental disease.

PI_NAMEs: QIAN, GUOQING  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Actins;Asbestos;Bleomycin;Blood Coagulation Factor;Carbon Black;cell motility;cell type;Cells;Cicatrix;Clinical;clinically significant;Collagen;Cytokinesis;Cytoskeletal Modeling;Data;Development;Disease;Dyspnea;epithelial to mesenchymal transition;Fibronectins;Fibrosis;Genes;Goals;Human;Impairment;in vivo;Infection;Inflammatory;Invaded;knock-down;Knock-out;Knockout Mice;Knowledge;Lung Diseases;Mediating;Mediator;Mesenchymal;Mesothelial Cell;Mesothelium;migration;Modeling;new therapeutic target;novel;Pathogenesis;Pathway interactions;Patients;Pharmacological Treatment;Play;Pleura;Pleural;Pleural Diseases;Pleural Mesothelial Cell;Pleurisy;Process;Public Health;pulmonary function;Refractory;Role;Signal Transduction;Smooth Muscle;Snails;Streptococcus pneumoniae;Testing;Therapeutic;Therapeutic Intervention;transcription factor;Transforming Growth Factor beta;Up-Regulation

PROJECT_TITLE: D0CK2 in pleural fibrosis-Diversity Supplement


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Narrative Leukemia stem cells are responsible for poor clinical outcomes in patients with acute myeloid leukemia, and the proposed research addresses a need to better understand the mechanisms that underlie their function. We recently discovered that the cell surface marker CD99 promotes leukemia stem cell self-renewal by constraining protein synthesis, establishing a new link between regulated protein synthesis and leukemia stem cell function. By elucidating the mechanisms underlying why leukemia stem cells depend on regulation of protein synthesis across different subtypes of acute myeloid leukemia, this project has the potential to establish a new paradigm for how cancer stem cells sustain themselves, as well as to guide the design of more effective therapies targeting leukemia stem cells to improve clinical outcomes for patients with acute myeloid leukemia.

PI_NAMEs: CHUNG, STEPHEN SHIU-WAH (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Adopted;BCL2 gene;Biogenesis;biological adaptation to stress;cancer stem cell;Cell surface;Cells;Clinical;Dependence;design;Development;effective therapy;Evaluation;Exhibits;Genetic;Genetically Engineered Mouse;Goals;graduate student;Grant;Hematopoietic stem cells;high risk;Human;Impairment;improved;inhibitor;innovation;insight;Knowledge;leukemic stem cell;Link;Maintenance;Malignant Neoplasms;Modeling;mouse model;novel;novel therapeutic intervention;novel therapeutics;Outcome;overexpression;parent project;Patient-Focused Outcomes;Patients;prevent;Protein Biosynthesis;Protein Synthesis Inhibition;Proteins;Regulation;Research;response;ribosome profiling;Ribosomes;Role;self-renewal;stem cell function;stem cell model;stem cell self renewal;stemness;targeted treatment;Testing;therapy development;therapy resistant;Translating;Tumor Suppressor Proteins

PROJECT_TITLE: Diversity Supplement for R37 Grant

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Efforts towards understanding how SARS-CoV-2 causes lung disease have been hampered by a lack of studies in novel circulating variants and a lack of relevant human lung models. The proposed studies will use a panel of primary viral variants and advanced single-cell analyses to study the early interferon response in novel lung organoid and slice cultures. Successful completion of this project will reveal mechanisms of SARS-CoV-2 pathogenesis and launch my career in the study of the host response to acute respiratory infections.

PI_NAMEs: RUSTAGI, ARJUN  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Acute;acute infection;Acute respiratory infection;Advisory Committees;Air;Alveolar Cell;Alveolar Macrophages;Animals;Autoantibodies;Automobile Driving;Basal Cell;Biology;career;career development;Cell Communication;Cell Line;cell type;Cells;Cessation of life;combat;Communicable Diseases;COVID-19;COVID-19 pandemic;COVID-19 pathogenesis;COVID-19 patient;cytokine;Data;Dependence;design;Development;Development Plans;Disease;Emerging infection;Environment;Epithelial Cells;Epithelium;Event;Flow Cytometry;Funding;Gene Expression;Genes;global health;Goals;high risk;Human;IL18 gene;Immune;immune activation;immune cell infiltrate;Immune response;Immunity;Immunology;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;innate immune pathways;Innate Immune Response;insight;instructor;Interferon Type I;Interferons;Interleukin-6;Knowledge;Liquid substance;Lung;Lung Diseases;Macrophage;Macrophage Activation;Manuscripts;Maps;Mentors;Microscopy;Modeling;Mucous Membrane;Mutation;nasopharyngeal swab;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;Organoids;pandemic disease;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Physicians;Play;Positioning Attribute;Process;Productivity;programs;Protein Analysis;protein expression;Quantitative Reverse Transcriptase PCR;remdesivir;Research;Resources;respiratory;respiratory pathogen;respiratory virus;response;Rest;RNA amplification;Role;Sampling;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;SARS-CoV-2 variant;Scientist;severe COVID-19;Signal Transduction;single cell analysis;single-cell RNA sequencing;Slice;statistics;stem cells;Stimulus;Structure of parenchyma of lung;success;Supporting Cell;System;targeted treatment;Techniques;Testing;Therapeutic Intervention;TNF gene;tool;Training;Transcript;Tropism;Universities;vaccine delivery;vaccine hesitancy;Variant;variant of interest;variants of concern;Viral;Viral Pathogenesis;Viral Proteins;Virus;Virus Replication;Work

PROJECT_TITLE: Modeling early SARS-CoV-2 pathogenesis in human lung organoids and slice cultures

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Cancer;Skin Cancer

ORG_CITY: Auburn

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: Despite advances in treating many cancers, metastatic skin cutaneous melanomas that harbor a wild-type BRAF gene (“wild-type BRAF melanomas) remain very difficult to treat. Here we test the hypothesis that ERBB4 gain-of-function mutant proteins interact with the EGF receptor or HER2/Neu receptor to stimulate the PI3K pathway, which cooperates with the mutations in the RAS or NF1 genes to drive the proliferation of wild-type BRAF melanomas. Thus, we predict that the successful completion of the proposed research will lead to sorely needed improvements in treating a very aggressive cancer.

PI_NAMEs: RIESE, DAVID J. (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Address;BRAF gene;Cell Line;Cutaneous Melanoma;Data;Development;Epidermal Growth Factor Receptor;erbB-2 Receptor;ERBB2 gene;ErbB4 gene;gain of function;Gene Mutation;Genetic Transcription;Immune checkpoint inhibitor;improved;inhibitor;Knowledge;Malignant Neoplasms;MEKs;Melanoma;Melanoma Cell;mutant;Mutation;NF1 gene;outcome prediction;Outcome Study;Pathway interactions;Patient Care;PIK3CG gene;Proliferating;Proteins;Publishing;RAS genes;Research;Signal Transduction;Skin;Skin Cancer;Testing;Therapeutic Intervention;tumor

PROJECT_TITLE: Is ERBB4 a Driver of BRAF WT Melanomas?


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Tobacco;Tobacco Smoke and Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Black/African American men have the highest rate of lung cancer morbidity and mortality among all groups, with a 12% higher lung cancer incidence rate and a 15% higher lung cancer death rate than White/European men. We have identified a small genetic difference (called a single nucleotide polymorphism or “SNP”), that is rare in White/European individuals but is present in one third of Black/African American individuals. The SNP might affect the function of a protein involved in detoxification responses to tobacco smoke, and may thereby affect the lung cancer risk of smokers carrying this SNP. If true, this will be important information supporting lung cancer screening and tobacco cessation efforts in the Black/African American community.

PI_NAMEs: OFFRINGA, ITE A (contact)

PROJECT_TERMS: Affect;African American;African American population;Alleles;alveolar epithelium;Amino Acids;ARNT gene;Aromatic Polycyclic Hydrocarbons;Aryl Hydrocarbon Receptor;ATAC-seq;Binding;Biochemical;Biosensor;Black American;Black race;Cancer Death Rates;cancer health disparity;cancer risk;Carcinogens;Cell Line;Cells;Cessation of life;chromatin immunoprecipitation;cigarette smoke;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Communities;Complex;Data;dimer;Dimerization;Dissociation;Drug Metabolic Detoxication;Engineering;European;European ancestry;Exons;Gene Frequency;Genes;Genetic;genetic association;Genetic Risk;Genetic Variation;Genome;genome editing;genome wide association study;Genotype;Health Disparities Research;Heterodimerization;Human;improved;In Vitro;Incidence;Individual;insight;instrument;Kinetics;Leucine;lung cancer screening;male;Malignant neoplasm of lung;Measures;men;Metabolism;Minor;Modeling;Molecular Conformation;Morbidity - disease rate;mortality;Outcome;parent grant;Pilot Projects;Population;Positioning Attribute;Production;Proline;Protein Analysis;Protein Dynamics;protein function;Proteins;receptor binding;Recombinant Proteins;Research;response;Response Elements;Role;Single Nucleotide Polymorphism;Site;Smoker;Smoking;smoking-related cancer;Structure;Techniques;Testing;Tobacco smoke;tobacco smoke exposure;Tobacco Use Cessation;Training;transcriptome sequencing;transcriptomics;Variant;Xenobiotics

PROJECT_TITLE: Analysis of a missense SNP in the aryl hydrocarbon receptor repressor gene that may disproportionately increase lung cancer risk in Black Americans


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

PHR: Project Narrative We will gain new, indept insights into TNBC’s dependence on dysregulated G6PD, TrxR1 NADPH, GSH and STAT3 functions and the preferential effects of inhibitors. X-ray crystallographic studies will give atomic level details into the direct interactions. The successful development of R001, R002 or H182, H333 and their combination therapy with ICI will provide a novel effective treatment for TNBC.

PI_NAMEs: TURKSON, JAMES K (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: 4T1;Antitumor Response;azetidine;biological adaptation to stress;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Treatment;cancer survival;Cell Cycle;Cell Cycle Arrest;Cell Death;Cells;chemotherapy;Combined Modality Therapy;Dependence;Development;DNA Damage;effective therapy;endoplasmic reticulum stress;Event;Gene Expression;Gene Expression Regulation;Genes;Glucosephosphate Dehydrogenase;Glycolysis;Growth;In Vitro;in vivo;Inbred BALB C Mice;inhibitor;insight;knock-down;Metabolic;Modeling;Molecular;NADP;Natural Products;Normal Cell;novel;Outcome;Oxidation-Reduction;Oxidoreductase;Pathway interactions;Pentosephosphate Pathway;Reactive Oxygen Species;Recurrent disease;response;senescence;small molecule inhibitor;STAT protein;STAT3 gene;Therapeutic;thioredoxin reductase 1;transcriptome sequencing;triple-negative invasive breast carcinoma;tumor growth;Tumor Tissue;X-Ray Crystallography

PROJECT_TITLE: Mechanistic studies of hirsutinolides and azetidine based small molecule inhibitors of STAT3


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: About 1 in 10 people aged 60 and over experience depression, which puts them at higher risk for other health problems such as diabetes and stroke. There is no single brain region that explains LLD; instead, LLD is associated with a complex pattern of many neural changes which can be challenging to interpret. This project will characterize the complex spatial distribution of LLD neural correlates across the brain into an interpretable low-dimensional framework.

PI_NAMEs: BIJSTERBOSCH, JANINE DIANE (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Address;Adopted;Age;aged;Anhedonia;association cortex;biobank;Biological Markers;Brain;Brain region;career;Career Choice;career development;cohort;Complement;Complex;Confounding Factors (Epidemiology);connectome;Data;Dementia;depressive symptoms;Development;Diabetes Mellitus;Dimensions;Doctor of Philosophy;executive function;experience;experimental study;extrastriate visual cortex;Foundations;Funding;geriatric depression;Geriatric Psychiatry;graduate school;Head;Health;Heterogeneity;high risk;Human;Image;Individual;insight;Investigation;Knowledge;Link;Literature;Maps;Measures;Mediating;Mental Depression;Mentors;Motion;mouse model;multimodality;neural;neural correlate;neural patterning;Neurobehavioral Manifestations;neuroimaging;Outcome;Parents;Pathway interactions;Pattern;Persons;Phenotype;Population;programs;Public Health;Reaction Time;Readiness;Reproducibility;Research;Research Support;response;Rest;Role;rumination;Scanning;Scientist;Severities;sex;Sleep disturbances;somatosensory;Somatosensory Cortex;Spatial Distribution;Specificity;Stroke;Symptoms;Thick;Training;United States National Institutes of Health;Variant;Visual;Visual Cortex;Work

PROJECT_TITLE: Comparing sensorimotor and association cortex contributions in late life depression

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]