NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Genetics;Heart Disease;Hematology;Infectious Diseases;Rare Diseases;Stroke;Vector-Borne Diseases

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: Project Narrative This project will investigate the molecular mechanisms by which assembly of HNF4-nucleoproteins complex and epigenome signature is disturbed to increase in coagulation factors’ gene expression and coagulopathy in Chagas disease. Our studies may lead to novel therapeutic strategies to control Chagas and other cardiac and cerebrovascular disorders in which coagulopathy is a key contributing factor.

PI_NAMEs: GARG, NISHA JAIN (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: 5' Untranslated Regions;Abbreviations;Acetylation;Acute;adaptive immunity;Address;Adult;Affect;Affinity;Androstanes;Antibodies;Anticoagulants;Antigen-Presenting Cells;Antisense Oligonucleotides;Attention;Benznidazole;Binding;Blood coagulation;Blood Coagulation Disorders;Blood Coagulation Factor;Blood flow;Blood Platelets;Blood Vessels;Brain;burden of illness;Cardiomyopathies;Cerebrovascular Disorders;Cessation of life;Chagas Disease;ChIP-seq;chromatin immunoprecipitation;Chronic;Chronic Phase;Clinical;Coagulation Factor Gene;Coagulation Process;Communicable Diseases;Complex;Conditioned Culture Media;Cyclic GMP;Data;Data Set;Defect;Development;Disease;DNA;DNA Packaging;Economic Burden;Endothelial Cells;Epigenetic Process;epigenome;Etiology;Event;Exons;experience;Experimental Models;Exposure to;extracellular vesicles;fetal;Fibrin;Fibrinogen;Frequencies;Gene Activation;Gene Expression;Genes;Genetic Transcription;Globin;Goals;Health;Health Care Costs;Heart;Heart Diseases;Hemophilia A;Hemostatic Agents;Hemostatic function;Hepatic;Hepatocyte;hepatocyte nuclear factor;Heterodimerization;Histones;HNF4A gene;Homo;Human;In Vitro;in vivo Model;Incidence;Infection;Inflammatory;insight;Investments;Ischemic Stroke;Left ventricular structure;Literature;Liver;Lysine;Macrophage;Mammals;Methylation;Molecular;mortality risk;mouse model;Mus;Myocardial Ischemia;Nervous System Disorder;Neuraminidase;novel;novel therapeutic intervention;novel therapeutics;Nucleoproteins;Outcome;Parasites;Parasitic Diseases;Pathogenesis;Pathogenicity;Patients;Pattern;Peroxisome Proliferator-Activated Receptors;PF4 Gene;Pharmaceutical Preparations;Phase;Plasma;plasma protein Z;Platelet Activation;pregnane X receptor;premature;prevent;Process;Productivity;promoter;Promoter Regions;Protein C;Protein Isoforms;Protein S;Proteins;Prothrombin;Reactive Oxygen Species;recruit;Recurrence;Regulation;Research Personnel;RNA Splicing;Role;Signal Transduction;Site;Stress;Stroke;stroke incidence;Testing;Thromboembolism;thrombogenesis;thromboinflammation;Thrombophilia;Thromboplastin;Thromboxanes;Thrombus;Tissues;tool;transcription factor;Transcriptional Activation;Transcriptional Regulation;Trypanosoma cruzi;Untranslated Regions;Variant;vascular injury;Western Blotting

PROJECT_TITLE: Targeting HNF4-induced thrombo-inflammation in Chagas disease


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: WASHINGTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE The proposed T32 program for Clinical Research Training for the Fetal-Neonatal Brain will train the next generation of clinician-scientists in the research methodologies required to advance understanding of the developing human brain in vivo. The 2-3 year multidisciplinary research training program will focus on rigorous research methodology, advanced multimodal neurodiagnostic techniques for the fetus and newborn, and post- acquisition data processing, interpretation and analysis. The expertise developed will be critical for the formulation of future preventive neuroprotection strategies for the fetus and newborn.

PI_NAMEs: DU PLESSIS, ADRE JACQUES;LIMPEROPOULOS, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Clinical;fetal;neonatal brain;Pediatric Research;Research Training

PROJECT_TITLE: Clinical Pediatric Research Training for the Fetal-Neonatal Brain


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: PORTLAND

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE During S phase, essential nuclear processes such as DNA replication, transcription, and chromatin re- establishment must be coordinated to ensure genetic and epigenetic stability are maintained. These processes operate within the confines of spatially-distinct condensates and nuclear bodies, yet the mechanisms that regulate their spatial dynamics remain unknown. The goals of our research are to elucidate the mechanisms that regulate transcription condensate dynamics during DNA replication, to discover the pathways that balance histone biosynthesis to ensure epigenetic stability, and to understand how cells re-establish 3-dimensional chromatin structure following DNA replication.

PI_NAMEs: SALDIVAR, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: 3-Dimensional;Acute;Anabolism;Appearance;ATR gene;biological adaptation to stress;Cell division;Cells;Chromatin;Chromatin Structure;Coupling;DNA biosynthesis;DNA damage checkpoint;Enhancers;Ensure;Epigenetic Process;Equilibrium;Exhibits;Genes;Genetic;Genetic Enhancer Element;Genetic Transcription;Genome;Goals;Histones;Human Genome;Molecular Conformation;mRNA Precursor;novel;Nuclear;Pathway interactions;Phosphotransferases;Physical condensation;Positioning Attribute;prevent;Process;Production;programs;promoter;replication stress;Research;RNA Polymerase II;S phase;Signal Transduction;Technology;transmission process

PROJECT_TITLE: Nuclear dynamics maintaining chromatin integrity during DNA replication

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Many neurological disorders, including Parkinson's and Alzheimer’s Diseases impair attention, working memory and other foundational cognitive functions, which are thought to depend upon the interactions between different thalamic nuclei and cortical regions. This study will clarify the interactions among the many distinct cortical and thalamic sub-regions during normal cognitive function, and when some regions are impaired, yielding insights into the brain processes underlying symptoms of many patients.

PI_NAMEs: REIMERS, MARK ALLAN (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Affect;Affective;Alzheimer's Disease;Anatomy;Animal Experiments;Animal Model;Animals;Area;Attention;Auditory;Auditory system;barrel cortex;Behavior;Behavioral;Brain;Brain region;Cell Nucleus;Cells;Cognitive;cognitive function;cognitive process;cognitive task;Compensation;Complex;Computer Analysis;computerized tools;Cues;design;Discrimination;discrimination task;Disease;Dorsal;Face;Feedback;Fiber;Health;Image;Impairment;insight;interest;Knock-out;Learning;lens;Link;Measures;Medial;Mediating;Mental disorders;Microscope;Modality;Monitor;Morphology;Motion;Motivation;Motor;mouse model;Movement;Mus;Nervous System Disorder;network dysfunction;neural;Neurons;optogenetics;Paper;Parkinson Disease;Pathway Analysis;Patients;Pattern;Perception;Performance;Photometry;Positioning Attribute;Process;Recurrence;Role;Sensory;sensory discrimination;sensory integration;Short-Term Memory;skill acquisition;skills;somatosensory;Speed;Symptoms;System;Tactile;Techniques;Thalamic Nuclei;Thalamic structure;tool;Touch sensation;Training;two-photon;Vibrissae;Visual;Visual System;Work

PROJECT_TITLE: CRCNS: Dynamics of thalamocortical networks during sensory discrimination


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Tobacco;Tobacco Smoke and Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed study will generate population-based data on the effectiveness of lung cancer screening with low dose computed tomography. These results have the potential to inform patient and clinician shared decision- making conversations and future US Preventive Services Task Force evidence reviews. As the number of patients screened for lung cancer increases due to expanded eligibility criteria, this research is timely and responsive to the National Cancer Institute’s goal to support research in cancer control that will help inform guideline development and policy decisions.

PI_NAMEs: HENDERSON, LOUISE  (contact)

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: Academy;Adherence;Adult;Affect;Age;aged;American College of Radiology;Attitude;Behavior;black men;black patient;Black Populations;Black race;black women;Cancer Control;Cancer Detection;Cancer Etiology;cancer risk;Caring;Cessation of life;Characteristics;Cigarette;clinically significant;Communities;Continuity of Patient Care;Data;Development;Disparity;Effectiveness;Eligibility Determination;Ethnic Origin;evidence base;experience;follow-up;Funding;Future;Goals;Guidelines;Heterogeneity;high risk population;imaging facilities;improved;Individual;innovation;Knowledge;Life;low dose computed tomography;Lung;lung cancer screening;Lung nodule;Malignant neoplasm of lung;Medicine;men;Methods;Modeling;mortality;National Cancer Institute;North Carolina;Not Hispanic or Latino;Outcome;Participant;patient screening;Patients;Pattern;Patterns of Care;Performance;pilot test;Policies;Population;population based;Population Heterogeneity;practice setting;Predictive Value;primary care provider;Procedures;Race;radiologist;randomized trial;Randomized, Controlled Trials;Recommendation;Recording of previous events;Registries;Research;Research Priority;Research Support;Risk;screening;screening guidelines;Screening Result;sex;Sex Differences;shared decision making;Smoke;Smoking;smoking exposure;Smoking History;Specificity;Surveys;Testing;Training;United States;United States National Institutes of Health;United States Preventative Services Task Force;Update;Vulnerable Populations;Woman;women patients;women versus men

PROJECT_TITLE: Evaluating Lung Cancer Screening Patterns and Outcomes in Diverse Populations and Settings

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Pediatric;Prevention;Substance Misuse

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Problematic cannabis use is common and leads to enormous personal and societal burden; thus, there is an urgent need to understand who is vulnerable, and why, in order to facilitate prevention and treatment. The current study will combine neural and behavioral measures with acute drug administration to better understand the neural mechanisms underlying the rewarding, reinforcing properties of cannabis. This work will ultimately contribute to a deeper understanding of brain and behavioral risk factors underlying problematic cannabis use and promote the development of targeted, prevention and intervention efforts for this population.

PI_NAMEs: CRANE, NATANIA A (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: abuse liability;Acute;addiction;Affective;affective neuroscience;aged;Area;behavior measurement;Behavioral;Biometry;Brain;brain behavior;Cannabis;Cannabis Abuse;career;Classification;Clinical;Cohort Studies;Coupled;design;Development;Double-Blind Method;Drug abuse;drug reward;Drug usage;Electroencephalography;Equipment and supply inventories;Euphoria;Event-Related Potentials;Exhibits;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Future;Goals;Human;Hyperactivity;indexing;Individual;Individual Differences;Intervention;Knowledge;Life;Link;marijuana use;marijuana use disorder;Measures;Medial;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Methods;multimodality;neural;neuromechanism;novel;Outcome;Participant;Patient Self-Report;Pharmaceutical Preparations;Phase;Phenotype;Placebos;Population;Prefrontal Cortex;Prevention;Property;Reporting;Research;Resolution;response;reward circuitry;reward processing;Rewards;Risk;Risk Factors;Scientist;skills;Substance Use Disorder;substance use treatment;temporal measurement;Tetrahydrocannabinol;Time;Training;Ventral Striatum;Visit;Work;young adult

PROJECT_TITLE: Brain-Behavior Markers of Reward and Cannabis Abuse Risk in Young Adults

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Tuberous Sclerosis

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: This project will use measurements of altered mTOR signaling pathways in neural cell types of the human brain and address how these abnormalities impact various developmental stages, spanning early neural progenitor cells to neurons and glia found in the postnatal brain, using patient-derived cells and models.

PI_NAMEs: ESS, KEVIN C;IHRIE, REBECCA A (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Acute;Address;Affect;Aftercare;Age;analysis pipeline;Archives;autism spectrum disorder;Behavioral;Benign;biobank;Biological Models;Body System;Brain;Brain Neoplasms;Cardiac;Cell Cycle;cell growth;Cell Line;Cell Lineage;Cell Physiology;Cell Survival;cell type;Cells;cellular imaging;Cerebrum;Clinical;cohort;Complex;computational pipelines;Cortical Malformation;Coupled;Cryopreservation;Custom;Cytometry;Data;Data Set;design;Development;Disease;Disease Progression;Dissociation;Drug Exposure;Electrophysiology (science);Embryonic Development;Engineering;Epilepsy;excitatory neuron;Flow Cytometry;FRAP1 gene;Future;Genes;Germ Lines;Hamartoma;Heterozygote;Human;human induced pluripotent stem cells;Image;In Vitro;Individual;induced pluripotent stem cell;inhibitory neuron;Institution;Intellectual functioning disability;Kidney;Kinetics;Lesion;Life;Lung;Mammals;Measurement;Measures;Mediating;Mental disorders;Modeling;mTOR Signaling Pathway;mTORopathies;multiplexed imaging;mutant;Mutation;mutational status;nerve stem cell;neural;neurodevelopment;Neuroglia;Neurologic Symptoms;Neuronal Differentiation;Neurons;Organ;Organoids;Outcome;Partial Epilepsies;Pathogenesis;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphoproteins;Phosphotransferases;postnatal;Process;progenitor;Protein-Serine-Threonine Kinases;Proteins;Protocols documentation;Publishing;Regulation;Resected;response;RNA;Series;Serine;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem cells;Symptoms;Systems Biology;Testing;Therapeutic Intervention;Time;tissue fixing;Tissues;TSC1 gene;TSC1/2 gene;TSC2 gene;Tuberous Sclerosis;tumor

PROJECT_TITLE: Identifying mTOR Dependent Periods During Brain Development

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF-R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE: Amnestic mild cognitive impairment (aMCI) is an early stage in the Alzheimer’s clinical syndrome, and it will be important to determine whether biological processes in aMCI might differ due to a remote history of mild traumatic brain injury (mTBI). To this end, the proposed study will combine state-of-the-art high definition transcranial direct current stimulation and blood-derived biomarker tools with comprehensive clinical and cognitive information to inform whether the biological changes in aMCI relate to a history of mTBI. This new information will provide the necessary groundwork to begin identifying the biological processes for how ACS is related to TBI, which could eventually lead to the development of new interventions to mitigate risk for ACS in older adults with a TBI history.

PI_NAMEs: LOBUE, CHRISTIAN BARRETT (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Acute;Adult;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;amnestic mild cognitive impairment;Biological;Biological Factors;Biological Markers;Biological Process;Blinded;Blood;blood-brain barrier crossing;career;career development;Cells;Clinical;Cognitive;Crossover Design;Data;Dementia;design;Development;Early Onset Alzheimer Disease;Enrollment;Episodic memory;experience;extracellular vesicles;Goals;Growth;Individual;Inflammation;Injury;insight;Interleukin-6;Intervention;Knowledge;Leadership;Left;Light;Link;Liquid substance;Measures;Memory;Memory impairment;Mentors;Mentorship;Methods;mild cognitive impairment;mild traumatic brain injury;Modeling;neural circuit;neurobehavioral;neurofilament;neuron loss;Neuronal Injury;Neurons;noninvasive brain stimulation;older adult;Pathologic;Pathway interactions;Positioning Attribute;Protein Isoforms;public health relevance;Publications;Publishing;Recording of previous events;Research;research and development;Research Design;response;Risk;Risk Factors;risk mitigation;skills;Syndrome;tau-1;Testing;Theoretical model;Therapeutic Intervention;therapy development;tool;Training;transcranial direct current stimulation;Translational Research;Traumatic Brain Injury;Traumatic brain injury related dementia;verbal

PROJECT_TITLE: Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History (PATH)

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE The emergence of antibiotic resistant bacteria poses an immense threat to public health, but we know little about the mechanisms that explain why some strains, out of the huge diversity of a bacterial species, are more likely to become and stay resistant. The project in this proposal aims to address this gap in knowledge, focusing on the common pathogen Neisseria gonorrhoeae, the cause of the sexually transmitted disease gonorrhea. We expect this project will facilitate novel strategies to prevent, control, and treat antibiotic resistance.

PI_NAMEs: GRAD, YONATAN H (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Acceleration;acquired drug resistance;Address;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;antimicrobial;Antimicrobial Resistance;Australia;Bacteria;Bacterial Antibiotic Resistance;Bacterial Physiology;Bar Codes;Biology;burden of illness;Candidate Disease Gene;candidate identification;candidate validation;Case Study;Ceftriaxone;Ciprofloxacin;Clinical;Clinical Management;clinically relevant;Complex;cost;Data;Data Set;Development;Drug Binding Site;Drug Exposure;Drug resistance;Drug Targeting;Epidemiologic Monitoring;Europe;Evolution;fitness;Genes;Genetic;Genetic Determinism;genetic resistance;Genome;Genomic approach;genomic locus;genomic tools;Genotype;Goals;Gonorrhea;high risk;improved;In Vitro;Infection;innovation;Knowledge;large datasets;Libraries;Link;Literature;Maintenance;Metabolic;Methods;Molecular;Multi-Drug Resistance;Mutagenesis;Mutation;Nature;Neisseria gonorrhoeae;novel;novel strategies;pathogen;pathogenic bacteria;Pathway interactions;Pharmaceutical Preparations;phase III trial;Phenotype;Phylogenetic Analysis;Phylogeny;Population;Population Genetics;Population Surveillance;Predisposition;Prevalence;prevent;Public Health;Publishing;Rapid diagnostics;Recommendation;Reporting;Resistance;Resistance development;resistance mechanism;resistant strain;Risk;Sampling;Sexually Transmitted Diseases;Specificity;Support Groups;support network;System;Testing;Therapeutic;tool;United States;Variant;Work

PROJECT_TITLE: Genomics approaches to elucidating pathways to antibiotic resistance in Neisseria gonorrhoeae

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIRT-J(01)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative. The National Cancer Institute estimates that in 2018, approximately 1.7 million people will be diagnosed with cancer in the United States alone, and of those, approximately 600,000 will succumb to their disease. One of the key drivers of cancer is the aberrant expression of cancer-causing proteins. This program will develop a platform to evaluate the efficacy of heterobifunctional small molecules for targeted degradation of currently “undruggable” metalloproteins activated during tumorigenesis or tumor progression.

PI_NAMEs: BURKART, MICHAEL D. (contact);COHEN, SETH M

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Acids;Active Sites;Apoptosis;Area;Binding;Biological Assay;Cancer Biology;cancer type;Catalytic Domain;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cell Reprogramming;Cell Survival;Chimera organism;Chromatin;Clinical;cofactor;Complex;Coupled;Cues;Cytosine;design;Development;Diagnosis;Disease;drug discovery;efficacy evaluation;Epigenetic Process;epigenetic regulation;Evaluation;Family;Foundations;Future;Gene Expression Regulation;Genes;Genetic Transcription;Goals;High Prevalence;high reward;high risk;histone methylation;histone modification;Histones;inhibitor;innovation;interest;Intervention;Ions;Iron;Left;Length;lens;Libraries;Ligand Binding;Ligands;Lysine;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;metalloenzyme;Metalloproteins;Metals;Methodology;Methylation;Modality;Modification;Molecular Target;National Cancer Institute;neoplastic cell;Normal Cell;novel;novel anticancer drug;Oncogenic;Oncoproteins;Oxygenases;Peripheral;Persons;pharmacophore;Phosphorylation;Post-Translational Protein Processing;preclinical development;Process;programs;Protac;protein degradation;Protein Isoforms;protein protein interaction;Proteins;Proteome;rapid technique;recruit;Regulation;Reporting;response;Role;Sequence Homology;Signal Pathway;small molecule;success;Surface;targeted agent;Technology;therapeutic development;Therapeutic Intervention;therapeutic protein;therapeutic target;tumor;tumor progression;tumorigenesis;ubiquitin-protein ligase;Ubiquitination;United States;Water

PROJECT_TITLE: Targeting Metal-Dependent Epigenetic Modulators via MetalloPROTACs


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Liver Disease;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Nearly half of patients with pancreatic neuroendocrine tumors (PanNET) present with liver metastases at diagnosis, which correlates with poor prognosis, and the immunosuppressive microenvironment of PanNET limits the efficacy of immune checkpoint inhibitors (ICI) for metastatic PanNET patients, with a less than 10% objective response rate. Emerging evidence suggests that increased vascular leakage and poor vascular perfusion resulting from vascular destabilization impair immune cell infiltration into tumors, thus facilitating tumor immune evasion and consequent tumor progression. In this work, we propose to study role of angiopoietin-2/Tie2 signaling, which regulates vascular destabilization and dysfunction, in liver metastatic progression and in ICI therapy resistance of metastatic PanNET as well as the potential of Tie signaling molecules as sensitive cancer biomarkers for PanNET patients.

PI_NAMEs: KIM, MINAH  (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Agonist;Angiopoietin-2;ANGPT2 gene;antagonist;anti-PD1 therapy;Binding;Biological Markers;Blocking Antibodies;Blood Vessels;cancer biomarkers;CD8-Positive T-Lymphocytes;Cell Physiology;checkpoint therapy;Clinical Management;Data;Development;Diagnosis;Disease;Endothelium;Excision;Extravasation;follow-up;Functional disorder;Genetic;Growth;high risk;Human;immune cell infiltrate;Immune checkpoint inhibitor;Immune Evasion;Immunodeficient Mouse;immunoregulation;Immunosuppression;Immunotherapy;Impairment;improved;Incidence;Inflammatory;insight;Islet Cell Tumor;Liver;liver function;Mediating;Metastatic Neoplasm to the Liver;mouse model;Mus;Neoplasm Metastasis;objective response rate;Operative Surgical Procedures;Patients;Perfusion;Plasma;potential biomarker;Primary Neoplasm;Prognosis;prognostic;Prognostic Marker;receptor;Receptor Protein-Tyrosine Kinases;Regulation;Resistance;response;Role;Sampling;Signal Transduction;Signaling Molecule;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;therapeutic target;TIE-2 Receptor;Time;transcriptome sequencing;tumor;tumor diagnosis;Tumor Escape;tumor growth;Tumor Markers;tumor progression;tumor-immune system interactions;Up-Regulation;Vascular remodeling;Work

PROJECT_TITLE: Angiopoietin-2/Tie2 signaling regulation of liver metastasis in pancreatic neuroendocrine tumors

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Mental Health;Neurosciences;Nutrition;Obesity;Pediatric;Precision Medicine;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Public Health Relevance The proposed research is relevant to public health because understanding predictors of initial treatment response and weight loss maintenance for adolescents with obesity will lead to an ability to match adolescents to personally effective treatment. Precision medicine approaches directed toward initial treatment response and weight loss maintenance will have the long-term impact of reducing the health burden of obesity, a chronic and impairing disease, as well as enhancing overall health and longevity. The current project directly responds to gaps identified by a recent NIH workshop on precision medicine in the context of adolescent obesity and addresses an NIDDK priority area of weight loss maintenance.

PI_NAMEs: GROSS, AMY C. (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent obesity;Adult;adult obesity;Affect;Agonist;Area;Behavior;Body mass index;Body Weight decreased;Brain;Brain region;Characteristics;Childhood;Chronic;Chronic Disease;Clinical;clinical application;clinical care;clinically relevant;Cognitive;comorbidity;comparative effectiveness trial;COVID-19 pandemic;critical developmental period;Cross-Sectional Studies;Cues;Data;Desire for food;Development;Disease;Educational workshop;effective intervention;effective therapy;executive function;experience;Exposure to;Factor Analysis;flexibility;Food;Foundations;Funding;GLP-I receptor;Goals;Health;Heterogeneity;high reward;Hyperphagia;Immersion;Impairment;improved;Individual;Informal Social Control;Inpatients;Intervention;Life Expectancy;Life Style Modification;Longevity;Maintenance;Medical;National Institute of Diabetes and Digestive and Kidney Diseases;neurobehavioral;neurodevelopment;novel strategies;Obesity;obesity treatment;Observational Study;Outcome;Parents;Participant;Pharmaceutical Preparations;Pharmacotherapy;Population;precision medicine;predicting response;Prediction of Response to Therapy;Predictive Factor;preference;Process;prospective;Public Health;public health relevance;Randomized;Research;Resistance;response;Rewards;Risk;Short-Term Memory;standard measure;Statistical Models;success;Time;treatment response;treatment strategy;United States National Institutes of Health;virtual;Weight Gain;Weight maintenance regimen;Youth

PROJECT_TITLE: Predictors of Weight Loss and Weight Loss Maintenance to Lifestyle Modification Therapy and Pharmacotherapy for Adolescents with Obesity

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PUBLIC HEALTH RELEVANCE Effective prevention, treatment, and recovery services for substance use disorders (SUD) and HIV and their effective implementation in real-world service settings can be achieved via adaptive interventions; these interventions explicitly guide the modification of the type/intensity of services (or implementation supports) based on the context and changing needs of individuals with or at risk for SUD/HIV and the settings where they receive care. However, (i) existing adaptive intervention approaches have been unable to harness the unprecedented opportunities offered by advances in digital technologies, such as electronic health records (EHRs) and mobile devices; and (ii) existing experimental designs and data analytics have not kept up with the critical questions investigators must address to optimize the adaptation of SUD/HIV services across different levels, modalities, and timescales. The focus of the Methodologies for Adapting and Personalizing Prevention, Treatment, and Recovery Services for SUD and HIV (MAPS Center) is the development, evaluation, and dissemination of novel data collection and data analysis methodologies that are essential to optimize adaptive interventions to combat SUD/HIV.

PI_NAMEs: ALMIRALL, DANIEL ;COLLINS, LINDA M;MURPHY, SUSAN A;NAHUM-SHANI, INBAL BILLIE (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: adaptive intervention;addiction;Address;Adoption;analytical method;Behavior;career;Caring;Clinic;Cocaine;combat;Complex;computer science;Data;Data Analyses;Data Analytics;Data Collection;design;Development;digital;digital data;digital technology;effective intervention;Effectiveness;Electronic Health Record;Engineering;Ensure;Evaluation;Evidence based intervention;experience;Experimental Designs;Generations;Grant;Guidelines;Hand;handheld mobile device;Health system;HIV;HIV Infections;Human;improved;Incidence;Individual;individualized prevention;innovation;interest;International;Intervention;Mentors;Methodology;Methods;Modality;Modification;Motivation;novel;Opioid;Outcome;outreach;Persons;Population;Positioning Attribute;prescription opioid;Prevalence;prevention service;Productivity;programs;public health relevance;recovery services;Recovery Support;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Risk;Science;Scientist;Service setting;Services;Substance Use Disorder;support tools;synergism;Testing;theories;Theory of Change;Time;Tobacco;Training;Translations;treatment services;Work

PROJECT_TITLE: Center for Methodologies for Adapting and Personalizing Prevention, Treatment and Recovery Services for SUD and HIV (MAPS Center)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Project Narrative Genetic alterations in human cancer have been systematically studied over the past decade, but the impact of a majority of these changes on the proteome – the functional end of the genome – are poorly understood. In this project we will use a state-of-the-art, unbiased analysis method, mass spectrometry-based proteomics, to define the protein content and identify key posttranslational modifications of the proteins that are involved in cell signaling. By integrating the proteomics data with the genomics and metabolomics data for the same samples/tumors we will shed new light on the biology of cancer and, importantly, we will help to identify new targets for therapeutic intervention.

PI_NAMEs: CARR, STEVEN A (contact);GILLETTE, MICHAEL A;SATPATHY, SHANKHA

PROGRAM_OFFICER_NAME: HILTKE, TARA

PROJECT_TERMS: Acceleration;Adoption;Affect;Algorithms;anti-cancer research;Antigen Presentation;antigen processing;Antigens;arm;Binding;Biocompatible Materials;bioinformatics tool;Biological;Biological Assay;Biology;Cancer Biology;cancer cell;Cancer Model;cancer therapy;cancer type;Cell Communication;Cell Separation;Cells;Clinical;Clinical Treatment;Collaborations;Communities;Complex;Core Biopsy;Data;data acquisition;Data Analyses;data integration;Data Set;Development;Devices;DNA;DNA copy number;drug development;Drug Targeting;epigenomics;Functional disorder;Genome;genomic data;Genomics;Goals;Guidelines;Histocompatibility Antigens Class I;HLA Antigens;Human;immunogenicity;Immunology;improved;innovation;insight;instrument;International;Investigation;Label;Libraries;Link;Literature;Location;Machine Learning;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;metabolomics;Methods;MHC binding peptide;Molecular;multidisciplinary;multiplex assay;Mutation;neoantigens;neoplastic cell;new technology;new therapeutic target;novel;Oncogenic;Organoids;Pathway interactions;patient derived xenograft model;Patients;Peptides;personalized cancer vaccines;personalized genomics;Pharmacotherapy;photonics;Population;Post Translational Modification Analysis;Post-Translational Protein Processing;pre-clinical;prediction algorithm;programs;Proteins;proteogenomics;Proteome;Proteomics;Publishing;Quantitative Evaluations;rare cancer;Reagent;Research;Sampling;Signal Transduction;Site;Specificity;Stable Isotope Labeling;Standardization;Technology;Therapeutic Intervention;Time;Tissues;transcriptomics;translational impact;Translations;tumor;Tumor Antigens;Tumor Escape;tumor heterogeneity;Tumor-infiltrating immune cells;Variant

PROJECT_TITLE: Center of Excellence for High Throughput Proteogenomic Characterization


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Infectious Diseases;Precision Medicine;Prevention;Recovery Support Services;Substance Misuse

PI_NAMEs: NAHUM-SHANI, INBAL BILLIE (contact)

PROJECT_TERMS: adaptive intervention;Address;Advisory Committees;Agreement;AIDS prevention;analytical method;Behavioral;Collaborations;Communication;Computer software;Creativeness;Data;Data Analyses;Data Analytics;data curation;data exchange;data management;data sharing;Data Storage and Retrieval;dissemination strategy;Educational workshop;Ensure;equity, diversity, and inclusion;experimental analysis;Feedback;flexibility;Fostering;Foundations;Funding;HIV;improved;individualized prevention;Infrastructure;innovation;Institutional Review Boards;Intervention;Lifting;meetings;method development;Methodology;Methods;Mission;Monitor;next generation;novel;Positioning Attribute;prevention service;Procedures;Productivity;Progress Reports;PubMed;Qualifying;Records;recovery services;Regulation;Reporting;Research;Research Personnel;Resources;Running;Science;Scientist;Services;Site;Substance Use Disorder;synergism;Technology;therapy development;Time;tool;Training;Training Activity;Translating;treatment services;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Admin-Core


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: NEW ORLEANS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative - Overall Tulane National Primate Research Center (TNPRC) has one of the largest specific pathogen free (SPF) rhesus monkey breeding colonies in the US, a resource that has provided animals for NIH funded research projects for several decades. Over half of all research projects at TNPRC are initiated by outside investigators, making this resource essential to the success of many NIH-funded researchers across the country. Experienced leadership and significant infrastructure investment, combined with proven techniques in breeding colony management, ensure continued responsible stewardship of this nationally recognized resource.

PI_NAMEs: RUSSELL-LODRIGUE, KASI E (contact)

PROGRAM_OFFICER_NAME: SUI, YONGJUN

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Address;Animals;Award;base;Behavioral;Breeding;Caring;Clinical;Communities;congenital infection;Cost Savings;Country;data management;Databases;demographics;Disease;Emerging Communicable Diseases;Ensure;Equilibrium;Exclusion;experience;Funding;Funding Agency;Funding Opportunities;Genetic;genetic analysis;genetic testing;Genetic Variation;germ free condition;Goals;Grant;HIV/AIDS;Human Resources;immunosuppressed;improved;Income;Individual;Infectious Agent;Infrastructure;Investigation;Investments;Leadership;Link;Macaca mulatta;Maintenance;Measles virus;Medical;Monitor;nonhuman primate;offspring;Opportunistic Infections;Pathology;Population;Population Genetics;Population Sizes;Primates;Procedures;Process;Production;Program Description;programs;Records;repaired;Research;Research Personnel;Research Project Grants;Resources;Sales;Source;Specific qualifier value;success;Techniques;Testing;Time;Trypanosoma cruzi;United States;United States National Institutes of Health;vaccine development;Viral;Virus;virus testing;Wages;Writing

PROJECT_TITLE: Tulane National Primate Research Center AIDS SPF Breeding Colony Maintenance


ADMINISTERING_IC: MH

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_NAME: LIFECANVAS TECHNOLOGIES, INC.

PHR: The ability to efficiently generate comprehensive datasets from large mammalian brains would enable researchers to investigate these complex structures more efficiently and systematically. Towards this goal, LifeCanvas Technologies will develop new tissue processing and imaging instruments for high-throughput, high-resolution, automated volumetric imaging of various large-scale mammalian brains. Together with LifeCanvas’ state-of-the-art tissue clearing, labeling and analysis pipeline, the new developments will provide the neuroscience research community with powerful tools to generate unprecedented, comprehensive datasets for a large variety of mammalian samples, including rodent, non-human primate and human brains.

PI_NAMEs: EVANS, NICHOLAS BRUCE;LEE, HSUAN ;STIRMAN, JEFFREY ;WANG, JI  (contact)

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TERMS: 3-Dimensional;analysis pipeline;Animal Organ;Autopsy;Axon;Brain;Brain Mapping;brain size;brain tissue;brain volume;cell type;Cerebral hemisphere;Chemicals;commercialization;Communities;Complex;Consumption;Custom;Data Set;design;Development;Disease;Face;Frequencies;Gel;Gelatin;Goals;Height;Human;Image;Imaging Device;imaging system;Individual;instrument;instrumentation;Label;large datasets;Length;Light;Maps;Mechanics;Methods;Microscope;Microscopic;microscopic imaging;Microtome - medical device;Molecular;Morphology;Movement;Mus;Neurons;Neurosciences;Neurosciences Research;new technology;nonhuman primate;optical imaging;Optics;Organ;Outcome;Permeability;Phase;Positioning Attribute;preservation;Process;Protocols documentation;prototype;Research Personnel;Resolution;Rodent;Sample Size;Sampling;Secure;Sepharose;Slice;soft tissue;Speed;Structure;Surface;System;Systems Integration;Techniques;Technology;technology development;Testing;Thick;Three-Dimensional Imaging;Time;Tissue imaging;tissue processing;Tissues;tomography;tool;Translating;user-friendly;vibration;Width

PROJECT_TITLE: High-throughput 3D mapping of large mammalian brains via integration of precision tissue sectioning and light sheet imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PI_NAMEs: BOHM, RUDOLF PAUL (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;animal care;Animals;Area;Award;base;Behavioral;Breeding;Caring;Clinical;clinical care;Cost Savings;data management;Databases;Decision Making;demographics;Diagnostic Services;Ensure;Equilibrium;experience;Fostering;Funding;Funding Agency;Genetic;germ free condition;Goals;Grant;HIV/AIDS;Housing;improved;Income;Individual;Infectious Agent;Laboratories;Link;Literature;Macaca;Macaca mulatta;Maintenance;Managed Care;Medical;Monitor;operation;Pathology;Philosophy;Population;Preventive Medicine;Primates;Procedures;Process;Production;programs;Recording of previous events;Records;Research;Research Personnel;Research Project Grants;Resources;Sales;Services;Source;success;Time;United States;United States National Institutes of Health;virus testing

PROJECT_TITLE: Husbandry and Management Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AARR-J]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Recovery Support Services;Substance Misuse

PI_NAMEs: BRAY, BETHANY C. (contact)

PROJECT_TERMS: adaptive intervention;Address;Adopted;Adoption;analytical method;analytical tool;Area;Award;career;Clinic;Code;Collaborations;combat;Communities;Computer software;Data;Data Analyses;Data Analytics;Development;Documentation;Electronics;empowerment;Ethics;Experimental Designs;Fostering;Goals;graduate student;Grant;HIV;individualized prevention;innovation;interest;Intervention;Learning;meetings;Mentors;Mentorship;method development;Methodology;Methods;Nature;Newsletter;next generation;novel;online course;online repository;online resource;Pilot Projects;pilot test;Postdoctoral Fellow;prevention service;programs;recovery services;repository;Research;Research Personnel;Research Project Grants;Resources;responsible research conduct;Sampling;Science;Scientist;Services;software development;software repository;Substance Use Disorder;success;tool;Training;Translation Process;treatment services;trial design;United States National Institutes of Health;Vacuum;web site;webinar;Work

PROJECT_TITLE: Dissemination and Training Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE Single amino acid variants in TREM2 have been identified by genome-wide association studies to be one of the strongest genetic risk factors for late-onset Alzheimer's disease (AD) and AD-associated variants in TREM2 impair TREM2's ability to bind and signal in response to ligands in the body, further affecting TREM2- mediated immune activation in AD. The central hypothesis of the proposed study is that the available drugs, including FDA-approved drugs, could bind TREM2 at either basic and/or hydrophobic binding site, allosteric effect of drugs at TREM2 either or two binding sites could regulate ligand binding at both sites to modulate TREM2-mediated immune activation in AD, and compensate for the loss of TREM2-mediated immune activities by AD-associated TREM2 variants. New knowledge gained from this study could have high impact for AD research and treatment by repositioning the available drugs to target TREM2 and further the insight into available drugs modulating TREM2-mediated immune activation, offering a molecular basis for strategy development of using available drugs including drug combinations to target TREM2 for AD treatment.

PI_NAMEs: SONG, YUHUA  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Affect;Allosteric Site;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease therapy;Amino Acids;Apolipoprotein E;apolipoprotein E-2;Binding;Binding Sites;Biological;Biophysics;Brain;CCL4 gene;Cell Lineage;Cell Physiology;Cells;Clinical Trials;Combination Drug Therapy;Compensation;Complementarity Determining Regions;Development;Docking;drug classification;Drug Combinations;Drug Modulation;drug repurposing;Drug usage;experimental study;extracellular;FDA approved;Free Energy;genetic risk factor;genome wide association study;genome-wide analysis;Hydrophobicity;Immune;immune activation;Immune response;Immune signaling;immunoregulation;Impairment;inflammatory modulation;Inflammatory Response;Innate Immune Response;innovation;insight;Interferometry;Knowledge;Late Onset Alzheimer Disease;Ligand Binding;Ligands;Mediating;Membrane;Methods;Microglia;Molecular;Molecular Conformation;Motion;Myelogenous;novel;Outcomes Research;Pharmaceutical Preparations;Phase;Phenotype;Positioning Attribute;pre-clinical;programs;receptor;Regulation;Research;response;Roentgen Rays;Role;Signal Transduction;simulation;Site;Structure;Testing;TREM2 gene;Validation;Variant;virtual screening

PROJECT_TITLE: Drugs repositioning to target TREM2 in Alzheimer disease


PI_NAMEs: ALLERS, CAROLINA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Animals;Antigens;Biological Assay;Breeding;Chickenpox;cost;Cytomegalovirus;Data;Detection;Development;diagnostic assay;Diagnostic Services;Frequencies;Funding;Future;Grant;Infant;interest;Laboratories;Lymphocryptovirus;Maintenance;Microbiology;Mission;nonhuman primate;offspring;Parents;pathogen;Pathogen detection;Performance;performance tests;Primates;programs;quality assurance;Research;Research Personnel;Research Support;Rhadinovirus;Rhesus;Sampling;screening;Shipping;Simian Foamy Virus;Simian Retroviruses;Simian virus 40;Site;SIV;Source;Subgroup;success;Surveillance Program;targeted agent;Techniques;Testing;Time;United States National Institutes of Health;Validation;Validity of Results;Veterinary Medicine;Viral Physiology;Virus;virus testing;working group

PROJECT_TITLE: Viral Testing Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Pulmonary Fibrosis

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Respiratory viral infections such as influenza and COVID-19 are frequent causes of acute respiratory distress syndrome (ARDS), which is often followed by a devastating long term morbid complication, post-viral pulmonary fibrosis. Despite the pulmonary endothelium playing an important role in the development of ARDS, the therapeutic potential of modulating EC dysfunction to prevent deleterious long-term consequences has not been well-explored. Reversing endothelial dysfunction and restoring pulmonary vascular integrity through augmentation of an endothelial receptor, S1PR1, could provide a novel strategy to promote lung repair and prevent viral-injury induced lung fibrosis.

PI_NAMEs: KNIPE, RACHEL S (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;Affect;Alveolar;Architecture;Attenuated;Automobile Driving;Back;Bleomycin;Blood Vessels;Bronchoalveolar Lavage Fluid;Cell Communication;Cell surface;Cells;Chronic;Chronic disability;Clinical Trials;clinically relevant;Coculture Techniques;Collagen;Complication;Contracts;Coronavirus;Coughing;Coupled;COVID-19;COVID-19 pandemic;Deposition;Development;Disabling condition;disabling symptom;Down-Regulation;Effector Cell;efficacy validation;Endothelial Cells;endothelial dysfunction;Endothelium;epidemic virus;exercise intolerance;Extracellular Matrix;Fibroblasts;Fibrosis;Functional disorder;gain of function;Gene Expression Profile;Genetic;Genetic Transcription;Human;in vivo;Influenza;Influenza A virus;influenzavirus;Injury;Interleukin-1 alpha;Interruption;Intervention;Lead;loss of function;Lung;lung injury;lung repair;Mechanical ventilation;Mediating;Mediator;Messenger RNA;Modeling;Molecular;mortality;mouse model;Mus;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;overexpression;Pathologic;pharmacologic;Phase;Phosphorylation;Physiological;Play;prevent;Process;Production;protein expression;Pulmonary Fibrosis;receptor;Recombinants;Recycling;repaired;Respiration Disorders;Respiratory Failure;response;Role;Severities;Shortness of Breath;Signal Induction;Signal Transduction;single-cell RNA sequencing;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Sterility;Surface;Survivors;System;Testing;Therapeutic;tissue repair;Tissues;transcriptomics;Transgenic Mice;Vascular Permeabilities;Viral;Viral Respiratory Tract Infection;Virus Diseases

PROJECT_TITLE: Loss of Endothelial S1PR1 Drives Post-Influenza Pulmonary Fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Maternal Health;Neurosciences;Pediatric;Pregnancy;Rare Diseases;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Project Narrative As survival becomes a standard expectation for infants with congenital heart disease (CHD), the focus of the clinical community is now shifting to understanding and improving long-term neurodevelopmental outcomes in these high-risk children. This study aims to understand the influence of impaired placenta and other maternal- fetal risk factors on fetal and postnatal brain development among CHD survivors. Findings from this study will lay the foundation for developing early, neuroprotective and/or neurorehabilitative interventions aimed at mitigating neurodevelopmental delay and improving quality of life in this population.

PI_NAMEs: RAJAGOPALAN, VIDYA  (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: Accounting;Adult;Affect;Age Months;Animal Model;Aorta;Automobile Driving;Biological Markers;Birth;Blood;blood oxygen level dependent;Blood Vessels;Brain;brain tissue;Cardiac;Cardiac Surgery procedures;Cardiovascular system;career;career development;Child;Clinical;clinically relevant;Communities;comparison control;Complex;Computational Technique;Computer Models;Congenital Abnormality;congenital heart abnormality;design;Development;Developmental Biology;Diabetes Mellitus;Diagnosis;Diagnostic;Doctor of Medicine;Endocrine;Environment;epidemiology study;Exhibits;expectation;fetal;Fetal Development;Fetal Reduction;Fetus;Foundations;Functional disorder;Gases;Goals;Grant;Health;Heart;Heart Abnormalities;hemodynamics;Heterogeneity;high risk;Hospital Costs;Human;Hypertension;imaging biomarker;Immunologics;Impairment;improved;in utero;in vivo;Incidence;Infant;Intervention;Lesion;life span;Link;Longitudinal Studies;Magnetic Resonance Imaging;maternal risk;Measures;Mentors;Metabolic;Metabolism;Methods;Modality;Modeling;Motion;Neurocognitive;neurodevelopment;Neurodevelopmental Impairment;neuroimaging;neurological rehabilitation;neuroprotection;novel;nutrition;Obesity;Operative Surgical Procedures;Organ;Organogenesis;Outcome;Oxygen;Patients;Pediatric cardiology;Perfusion;Physiology;Placenta;Placenta Diseases;Placentation;Population;postnatal;Pre-Eclampsia;Pregnancy;Pregnancy Complications;prenatal;Prenatal Diagnosis;prenatal disorder;prenatal therapy;Quality of life;Rehabilitation therapy;Research;Research Design;Research Proposals;Risk;Risk Factors;Role;Scientist;Site;skills;spatiotemporal;Structure;surgery outcome;Survivors;Techniques;Testing;Thrombosis;Time;Training;Variant;vascular abnormality;Vascularization;Villus;Wood material;Work

PROJECT_TITLE: Influence of placental impairments and maternal-fetal environment on neurodevelopmental outcomes in Congenital Heart Disease

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Precision Medicine;Prevention;Primary Health Care;Recovery Support Services;Substance Misuse

PI_NAMEs: ALMIRALL, DANIEL  (contact)

PROJECT_TERMS: Address;Adoption;Applet;Behavioral;Clinic;Code;Collaborations;Computer software;Data;Data Analyses;Death Rate;design;Development;Dose;drug testing;Educational workshop;Electronic Health Record;Ensure;evidence base;Evidence based practice;Experimental Designs;Feedback;Generations;Goals;Guidelines;Heterogeneity;HIV;implementation strategy;improved outcome;Individual;individualized prevention;Intervention;Methodology;Methods;Motivation;non-cancer chronic pain;Opioid;Patients;peer coaching;Policies;prescription opioid;prevention service;Primary Care;primary care patient;Process;Publishing;Randomized;recovery services;Risk;Sample Size;Scientist;Sequential Multiple Assignment Randomized Trial;service uptake;Services;skills;Speed;substance use;Substance Use Disorder;System;Techniques;Technology;theories;Time;tool;Training;treatment services;trial design;Update;Urine;user friendly software;user-friendly;webinar;Work;Writing

PROJECT_TITLE: MI-SMART: Methods for Optimizing Multilevel Adaptive Implementation Strategies to Promote the Adoption of Effective SUD and HIV Services


PI_NAMEs: VALLENDER, ERIC J. (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Alleles;animal data;Animal Husbandry;Animals;Behavioral;Breeding;Budgets;Collaborations;Communication Tools;Communities;Data;data sharing;Databases;Decision Making;deep sequencing;design;Development;Disease Progression;DNA Library;Ensure;evidence base;exome sequencing;experience;Funding;Future;Genetic;genetic information;genetic pedigree;genetic resource;Genetic Services;genetic testing;Genetic Variation;Genome;genome sequencing;genomic data;genomic variation;Genomics;Genotype;Geographic Locations;Geography;Goals;Grant;Haplotypes;Health;HIV/AIDS;Immune response;improved;Inbreeding;Infection;Informatics;Institution;Macaca mulatta;Maintenance;male;MHC Class I Genes;Mind;Monitor;nonhuman primate;Other Genetics;Output;Population;Predisposition;Preventive Medicine;Primates;Process;programs;Protocols documentation;reproductive;Research;Research Activity;Research Personnel;research study;Role;Scientist;Services;simian human immunodeficiency virus;SIV;Source;Structure;System;Targeted Research;Testing;testing services;Time;Translational Research;Visit;whole genome;Wisconsin;working group

PROJECT_TITLE: MHC Genetic Typing Core


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Cannabinoid Research;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative 5-10% of auditory nerve fibers in the inner ear (type II fibers) are thought to be involved in detecting loud sounds, and to possibly contribute to pathologies like noxacusis that can accompany hearing loss. Such deficits can substantially affect the ability to lead our everyday lives. This proposal seeks to identify and investigate multiple cellular pathways that may contribute to type II fiber activity and its changes after noise exposure, to provide a basis for preventing or curing inner ear pathologies related to type II fiber activity.

PI_NAMEs: GLOWATZKI, ELISABETH  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acoustic Nerve;Action Potentials;Acute;Adult;Affect;Apical;auditory stimulus;base;Brain Stem;Cannabinoids;Cochlea;Data;Endocannabinoids;Epithelial Cells;Exhibits;experimental study;Fiber;fiber cell;Frequencies;gain of function;Glutamate Receptor;Glutamates;Goals;Hearing;hearing impairment;Hyperacusis;Imaging Techniques;Inflammation Mediators;Inflammatory;Labyrinth;Lead;Loudness;Mediating;Monitor;Mus;Nature;Nerve Fibers;neuroregulation;noise exposure;Noise-Induced Hearing Loss;noxacusis;optogenetics;Outer Hair Cells;Pain;Pathology;Pathway interactions;prevent;Property;Rattus;Receptor Gene;Recording of previous events;response;Role;Signal Pathway;Signal Transduction;sound;Synapses;Synaptic Transmission;Tissues;Travel;Type II Hair Cell

PROJECT_TITLE: Type II Afferents and Cochlear Damage

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research;Rehabilitation;Stroke

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE A lack of basic knowledge about bilingual language organization prevents the adequate treatment of bilingual individuals after brain damage, leading to recovery rates that are well below those of their monolingual counterparts. The current project addresses this gap in our knowledge by testing healthy and aphasic bilingual individuals in behavioral and fMRI paradigms to identify the degree to which the cognitive and neural mechanisms that support bilingual language use are shared or distinct across languages and levels of linguistic representation. Obtaining this information constitutes a critical first step to potentially develop targeted intervention approaches that will maximize language recovery in post-stroke aphasia in a demographic group that will be the majority of the US population by 2040.

PI_NAMEs: BLANCO-ELORRIETA, ESTI  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TITLE: Language-specific and language-general mechanisms in bilingual aphasic individuals

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Recovery Support Services;Substance Misuse;Telehealth

PROJECT_TERMS: Acceleration;adaptive intervention;Address;AIDS prevention;analytical method;Area;Behavioral;Clinical;Collaborations;Computer software;Data;Data Analytics;design;Development;digital;digital delivery;digital intervention;digital technology;Drug usage;Educational workshop;Effectiveness;Electronic Health Record;Experimental Designs;experimental study;flexibility;Generations;Goals;Hand;Health Technology;HIV;Human;Hybrids;Individual;individualized prevention;innovation;Intervention;intervention program;Joints;Journals;Methodology;Methods;mHealth;Modality;Monitor;Motivation;multimodality;National Institute of Drug Abuse;novel;Patients;Peer Review;Persons;prevention service;Publishing;Randomized;randomized trial;recovery services;Risk;Sample Size;scaffold;Scientist;Sequential Multiple Assignment Randomized Trial;service delivery;Services;Software Tools;Specialist;Statistical Methods;substance use;Substance Use Disorder;synergism;telehealth;Therapeutic;Time;tool;Training;treatment services;trial design;user friendly software;user-friendly;Work

PROJECT_TITLE: Methods for Optimizing the Integration of Adaptive Human-Delivered and Digital SUD/HIV Services


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: NARRATIVE Rural populations in the U.S. are disproportionately burdened by cardiovascular disease and type 2 diabetes. Lifestyle modification interventions are needed that support long-term engagement in risk-reducing health behaviors. Our proposal will study the effects of a family focused, lifestyle intervention that is culturally tailored for use with rural Hispanic and non-Hispanic adults and will have significant potential for broad dissemination to reduce T2D and CVD health disparities in rural U.S. communities.

PI_NAMEs: MUDD, GIA  (contact)

PROGRAM_OFFICER_NAME: AKUBU-ODERO, MAUREEN KALAMBU

PROJECT_TERMS: active control;Address;Adult;Affect;Age;Behavior;behavior change;Behavioral;behavioral outcome;Biological;Blood Pressure;Body mass index;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;Cause of Death;Collaborations;Communities;community based participatory research;community intervention;community partners;comorbidity;comparison control;comparison intervention;Controlled Study;culturally appropriate intervention;Data;Death Rate;Diabetes Mellitus;diabetes risk;Disease;Disparity;Economic Conditions;Education;efficacy testing;ethnic disparity;Ethnic Origin;Ethnic Population;experience;Face;Family;Family member;family support;Feedback;Geography;Glycosylated hemoglobin A;good diet;group intervention;Health;Health behavior;health disparity;health inequalities;Health Resources;healthy lifestyle;Heart;Heart Diseases;High Prevalence;high risk;Hispanic;hispanic community;Hispanic Populations;hypercholesterolemia;Hyperglycemia;Hypertension;improved;indexing;Individual;Intervention;intervention effect;Kentucky;Life Style Modification;lifestyle intervention;lifetime risk;Lipids;Mediating;member;Modeling;Modification;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Nutritional;Obesity;Outcome;Participant;Pattern;Physical activity;physical inactivity;poor health outcome;Population;post intervention;Poverty;Prediabetes syndrome;Prevalence;Public Health;racial disparity;racial population;Randomized;Randomized, Controlled Trials;Research;Research Design;Resources;Risk;Risk Factors;Risk Management;Risk Reduction;Rural;Rural Community;rural dwellers;rural families;rural Hispanic;Rural Population;rural residence;Self Care;smoking prevalence;social;Social support;socioeconomics;Testing;Tobacco use;Unhealthy Diet;Urban Community;Urban Population;Weight maintenance regimen

PROJECT_TITLE: Heart of the Family: A Cardiovascular Disease and Type 2 Diabetes Risk Reduction Intervention in High-Risk Rural Families


NIH_SPENDING_CATS: Bioengineering;Cancer

ORG_CITY: SEATTLE

ORG_NAME: SAGE BIONETWORKS

ORG_STATE: WA

PHR: Narrative The DREAM Challenges is an organization supporting collaborative competitions, a crowd-sourced initiative to accelerate innovation and insight in the biomedical sciences. DREAM has hosted Challenges in oncology to facilitate the development, evaluation, and comparison of algorithms that are critical to this field, such as models for patient prognosis and diagnosis, and prediction of therapeutic response. The DREAM Challenges has established itself as an important resource for the cancer research community and will continue to innovate and expand into critical areas in cancer.

PI_NAMEs: BOUTROS, PAUL CHRISTOPHER;VARMA, SUSHEEL  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Acceleration;Address;Adoption;algorithm development;Algorithms;anti-cancer research;Architecture;Area;Assessment tool;Benchmarking;Biological;Biological Markers;Biological Models;Biology;Biomedical Research;Clinical;Clinical Trials;Collaborations;Communities;community building;Community Developments;community engagement;Complex;Computer software;Crowding;crowdsourcing;Data;data ecosystem;Data Protection;data reuse;Data Set;data sharing;design;Development;Diagnosis;Diagnostic;Disease;drug response prediction;Education;Educational workshop;empowerment;Ensure;Environment;Evaluation;Face;Fostering;Funding;genomic tools;Genomics;hackathon;Human;Image;Improve Access;improved;Incentives;Individual;Infrastructure;innovation;insight;Instruction;Libraries;life span;Malignant Neoplasms;Medicine;Methods;Modeling;Modernization;neoplasm resource;next generation;Oncology;open data;Output;outreach;Participant;Patient Care;patient prognosis;Performance;Plug-in;portability;Practice Guidelines;Prediction of Response to Therapy;Privatization;Process;prognostic;programs;Registries;Reproducibility;Research;Research Personnel;Reverse engineering;Running;Science;Services;Structure;symposium;Text;tool;tool development;virtual technology;Vision;Work

PROJECT_TITLE: Advancing method benchmarking and data sharing through crowd-sourced competitions in cancer research


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Clinical Research;Comparative Effectiveness Research;Health Services

PHR: PROJECT NARRATIVE Gout is the most prevalent inflammatory arthritis with a worsening global disease burden and a substantial and rising prevalence of cardiometabolic comorbidities, which in turn contribute to premature mortality. These trends highlight the shortcomings of our current approach to gout care and call for personalized comorbidity- integrated models of gout care with the potential to synergistically address gout and its comorbidities. This Career Development Award proposes to leverage real-world and patient-derived data to conduct rigorous comparative effectiveness studies to examine the gout benefits of pleiotropic cardiometabolic medications and identify comorbidity phenotype clusters of incident gout and their associated outcomes to inform personalized comorbidity-integrated gout care and help improve both gout morbidities and comorbidities.

PI_NAMEs: YOKOSE, CHIO  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: active comparator;Address;Adherence;Affect;Agonist;Angiotensin-Converting Enzyme Inhibitors;Area;Biological Markers;Biology;burden of illness;Calcium Channel Blockers;cardiometabolic risk;cardiometabolism;Caring;Chronic Kidney Failure;Clinic;Clinical;Clinical effectiveness;cohort;comorbidity;comparative effectiveness;Comparative Effectiveness Research;comparative effectiveness study;Data;data centers;data registry;Development;Diabetes Mellitus;Diagnosis;Doctor of Philosophy;East Asian;effectiveness research;Electronic Health Record;Emergency department visit;Enrollment;Environment;Epidemiology;evidence base;Evolution;Exhibits;experience;Faculty;Fellowship;Flare;Funding;General Hospitals;GLP-I receptor;Glucose;Goals;Gout;Guidelines;Heart Diseases;Hospitalization;Hypersensitivity;hypertension treatment;illness perceptions;Immunology;improved;improved outcome;Inflammatory Arthritis;inhibitor;instructor;Internal Medicine;K-Series Research Career Programs;Losartan;Manuscripts;Massachusetts;Medical Informatics;medical schools;Medicine;Mendelian randomization;Mentors;Mentorship;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;New York;Outcome;Outcome Measure;Outcomes Research;patient oriented;Patient Outcomes Assessments;patient safety;Patient-Focused Outcomes;Patients;Pattern;Peer Review;personalized care;Pharmaceutical Preparations;Pharmacoepidemiology;Phenotype;Physicians;Premature Mortality;Prevalence;prevent;Probability;prospective;Public Health Schools;Randomized, Controlled Trials;Recommendation;Registries;Research;Research Personnel;Residencies;response;Rheumatology;Risk;Risk Factors;Serum;skill acquisition;Sodium;symporter;Time;Training;Training Activity;treatment guidelines;trend;United States National Institutes of Health;Universities;Urate

PROJECT_TITLE: Personalized Comorbidity-Integrated Gout Care

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Electronic Nicotine Delivery Systems;Prevention;Tobacco

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE Although electronic nicotine delivery systems (ENDS), particularly e-cigarettes, are of substantial public health importance, our ability to accurately characterize and non-obtrusively track ENDS puff behavior is quite limited. To overcome this barrier, the proposed research will use a novel Flexible Robust Instrumentation of ENDS (FRIENDS) monitor to assess puff behavior in the lab and the natural environment among participants representing a wide range of ENDS devices and users. This work will markedly advance our understanding of ENDS use behavior, make available to the field a validated, inexpensive, flexible, and accurate method (the FRIENDS monitor) for use in future studies, and guide the development of improved self-report assessments.

PI_NAMEs: HAWK, LARRY W (contact);SAZONOV, EDWARD S

PROGRAM_OFFICER_NAME: LAND, STEPHANIE R

PROJECT_TITLE: Automatic detection of vaping rate and patterning in the lab and the natural environment using Flexible, Robust Instrumentation of Electronic Nicotine Delivery Systems (FRIENDS)

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Recovery Support Services;Rehabilitation;Substance Misuse

PI_NAMEs: MURPHY, SUSAN A (contact)

PROJECT_TERMS: adaptive intervention;Adult;Affect;AIDS prevention;Algorithms;Artificial Intelligence;Bayesian Method;Behavioral Medicine;Behavioral Sciences;Cellular Phone;Collaborations;Computer software;COVID-19;craving;Data;delivery vehicle;design;digital;digital delivery;digital health;digital intervention;digital technology;disorder prevention;Drug usage;Educational workshop;effective intervention;Effectiveness;Effectiveness of Interventions;Explosion;Generations;Goals;Health Technology;HIV;Individual;individualized prevention;Intervention;intervention cost;intervention delivery;Journals;Learning;Location;Methodology;mhealth interventions;Modernization;Motivation;opioid epidemic;overpopulation;Participant;Peer Review;person centered;Persons;Play;Population;population based;post-pandemic;prevention service;Prevention strategy;preventive intervention;Psychological reinforcement;Publishing;Recovery;recovery services;Research;response;Role;Scientist;service intervention;Services;simulation;smart device;smart watch;Societies;Stress;substance use;Substance Use Disorder;Testing;therapy design;Time;Training;treatment response;treatment services;trend;unnecessary treatment;user friendly software;user-friendly;Variant;wearable device;Work;Writing;young adult;Youth

PROJECT_TITLE: Continual Optimization and Personalization of Just-in-Time Adaptive Interventions for SUD  Prevention, Treatment, and Recovery


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

ORG_CITY: SYRACUSE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: SYRACUSE UNIVERSITY

PHR: PROJECT NARRATIVE The overarching goal of the Center for Aging and Policy Studies (CAPS) is to improve the health, well-being, and independence of middle-age and older adults by directly addressing some of today’s most pressing issues facing those adults and the families that care for them. Critical issues are the growing disparities in middle-age and older adult health across geographic areas and population subgroups, and the changing needs of the older adult population in terms of familial support and caregiving. CAPS will achieve its important goal by conducting innovative and rigorous research, providing state-of-the-art training to scientists conducting that research, and widely disseminating their research findings to other scientists, decision makers, and the public.

PI_NAMEs: MONTEZ, JENNIFER KARAS (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Address;Adult;Aging;Alzheimer's Disease;Area;Attention deficit hyperactivity disorder;caregiving;Caring;Collaborations;Communication;cost effective;Country;Data;Data Collection;data harmonization;data resource;Data Science;Data Set;Demography;Development;Dimensions;Disparity;Economic Conditions;Economics;Educational workshop;Ensure;experience;Family;Fostering;Foundations;Funding;Geographic Locations;geographic population;Goals;Grant;Health;human capital;Immigration;improved;Incubators;innovation;Institution;Instruction;Interdisciplinary Study;intergenerational;Leadership;Link;low socioeconomic status;Mentors;Methodological Studies;Methods;middle age;military veteran;Modeling;multidisciplinary;New York;older adult;organizational structure;Outcome;Personal Satisfaction;Persons;Pilot Projects;Policies;Population;population based;programs;prospective;Recording of previous events;Research;Resources;Role;rural area;rural-urban migration;Scholars Program;Scientist;Series;Shapes;Site;social media;Socioeconomic Status;Subgroup;Surveys;symposium;Training;trend;United States National Institutes of Health;Universities;virtual;visiting scholar;Work;Writing

PROJECT_TITLE: Center for Aging and Policy Studies


NIH_SPENDING_CATS: Aging

PROJECT_TERMS: Acceleration;Advisory Committees;Aging;Area;career;Child Care;Collaborations;Communication;cost effective;Demography;Development;disability;Discipline;Disparity;Economics;Educational workshop;Elements;Ensure;experience;Family;Fostering;Funding;Grant;Health;Home;human capital;Hybrids;innovation;Institution;Institutional Review Boards;interdisciplinary collaboration;Interdisciplinary Study;intergenerational;International;Leadership;Life Cycle Stages;Mentors;Methods;Modeling;Monitor;New York;operation;Outcome;Parents;Performance;person centered;Personal Satisfaction;Persons;Pilot Projects;Policies;Population;population based;Positioning Attribute;Private Sector;programs;prospective;recruit;Reporting;Research;Research Methodology;Research Proposals;Research Support;Role;Scholars Program;Scientist;Series;Site;skills;Structure;symposium;Testing;Training;Travel;United States National Institutes of Health;Universities;virtual;visiting scholar;Work

PROJECT_TITLE: Center for Aging and Policy Studies (CAPS) Core A: Administrative and Research Support Core


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Genetics;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative: The overarching goal of this study is to identify effective metabolic based diagnostic and therapeutic strategies to improve the overall survival of patients with Non-small cell lung cancer (NSCLC). We propose to investigate the positron emission tomography (PET) tracer, 18F-BnTP as a novel metabolic diagnostic and to develop metabolic based therapeutic strategies targeting oxidative mitochondrial metabolism in therapy resistant KRAS/LKB1 and EGFR mutant lung tumors. This work represents a new approach to overcoming therapy resistance in KRAS/LKB1 and EGFR mutant lung tumors – one in which the tumor’s metabolic and bioenergetic dependencies are profiled and then selectively targeted.

PI_NAMEs: SHACKELFORD, DAVID B (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: 3-Dimensional;Address;advanced disease;American;Area;Biguanides;Bioenergetics;Biological Markers;Biopsy;Cancer Patient;cancer therapy;Cell Line;Cell Respiration;checkpoint therapy;Classification;Clinical;Complex;Data;Dependence;Diagnosis;Diagnostic;diagnostic strategy;Disease;Disease Resistance;Dissection;driver mutation;Electron Transport;Epidermal Growth Factor Receptor;Exhibits;fluorodeoxyglucose;Functional Imaging;Gene Expression Profiling;Genetically Engineered Mouse;Goals;Health;Human;image guided;imaging probe;Immuno-Chemotherapy;Immunotherapy;improved;in vivo;in vivo evaluation;in vivo imaging;inhibitor;Knowledge;KRAS2 gene;Lung Adenocarcinoma;Lung Neoplasms;Maintenance;Malignant neoplasm of lung;Measures;Membrane Potentials;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;Mitochondria;mitochondrial membrane;mitochondrial metabolism;mutant;Mutation;nano-string;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel diagnostics;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenic;Oxidative Phosphorylation;patient derived xenograft model;Patients;Phenotype;Phosphorylation Inhibition;Physiological;Positron-Emission Tomography;Rationalization;Research;Resistance;Resistance development;Site;Spirometry;stem;STK11 gene;Structure;superresolution microscopy;Survival Rate;targeted treatment;Testing;Therapeutic;therapy development;therapy resistant;Time;Tracer;treatment response;tumor;tumor initiation;tumor metabolism;Tyrosine Kinase Inhibitor;uptake;Work

PROJECT_TITLE: In vivo imaging of mitochondria structure and function in therapy resistant lung tumors

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: WOLF, DOUGLAS A (contact)

PROJECT_TERMS: Acceleration;Advertising;Aging;Alzheimer's Disease;Applications Grants;Area;Awareness;Biological Markers;career;Cessation of life;Child;Collaborations;Consult;Consumption;Demographer;Demography;design;disability;Discipline;Drug Prescriptions;Drug usage;Economics;Educational workshop;Ensure;Evaluation;experience;Family;Food;Fostering;Funding;Funding Opportunities;Geographic Locations;Grant;Growth;Health;Housing;human capital;Income;innovation;Institution;intergenerational;Lead;Leadership;Life Cycle Stages;low socioeconomic status;Measures;Medicare;Mentors;Mentorship;Methodology;middle age;New York;Outcome;Parents;Personal Satisfaction;Pilot Projects;Policies;Population;population based;Population Research;Program Development;programs;prospective;Records;Research;Research Personnel;resilience;Role;rural area;Science;Scientist;Shapes;Shock;Site;social disparities;Substance Use Disorder;success;symposium;Translating;Uninsured Medical Expense;Universities;Veterans

PROJECT_TITLE: Center for Aging and Policy Studies (CAPS) Core B: Program Development (Pilot) Core


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project is a collaboration between three academic institutions and Aethlon Medical, Inc. The overarching objective is to improve response to immunotherapy by removing immunosuppressive exosomes from the circulation of patients with head and neck squamous cell cancer (HNSCC). Aethlon Medical, Inc. has developed a GMP-compatible device to remove circulating exosomes, the Hemopurifier. We will use the Hemopurifier to show that removal of exosomes from HNSCC patients’ blood prior to immunotherapy will promote immune cell recovery and significantly increase the response rate.

PI_NAMEs: WHITESIDE, THERESA L. (contact)

PROGRAM_OFFICER_NAME: MELILLO, AMANDA A

PROJECT_TERMS: Antibodies;Antitumor Response;arm;Blood;Cancer Patient;carcinogenesis;Cell Therapy;Cells;Characteristics;chemoradiation;Circulation;Clinical;Clinical Data;Collaborations;Combined Modality Therapy;Data;design;Development;Device Removal;Devices;Dialysis procedure;Disease;Disease Progression;Effector Cell;Excision;exosome;follow-up;Goals;Good Manufacturing Process;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;HPV positive;Immune;Immune checkpoint inhibitor;immune function;Immune Tolerance;Immunocompetence;Immunocompetent;Immunologic Markers;immunosuppressed;Immunosuppression;Immunotherapy;Impairment;improved;improved outcome;Institution;Ligands;Malignant Neoplasms;Medical;Metastatic/Recurrent;MicroRNAs;Minority;Molecular Profiling;Monitor;Monoclonal Antibodies;mouse model;novel therapeutics;Oncogenes;Operative Surgical Procedures;Patients;pembrolizumab;Phase;Phase II Clinical Trials;Plasma;Play;preclinical study;predictive tools;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;programs;Proteins;Recovery;Recurrence;Recurrent disease;Rejuvenation;relapse prediction;Reporting;Research;response;restoration;Role;Safety;Sampling;Site;Survival Rate;Testing;Therapeutic;Therapy trial;tumor;tumor ablation;tumor growth;Tumor Immunity;Tumor Promotion;Tumor-Derived;United States Food and Drug Administration;Unresectable;Virus

PROJECT_TITLE: Depleting exosomes to improve responses to immune therapy in HNSCC


PI_NAMEs: WILMOTH, JANET M (contact)

PROJECT_TERMS: Aging;aging related;Applications Grants;Area;Behavioral;Catalogs;Collaborations;Communication;community building;Data;data resource;Demography;design;Development;Economics;editorial;Educational workshop;Family;Funding;Generations;Grant;Health;Infrastructure;innovation;Instruction;intergenerational;Longitudinal Studies;Mentors;Modeling;next generation;older adult;Participant;Personal Satisfaction;Pilot Projects;Policies;Population;population based;Population Database;Population Process;Production;programs;Publishing;recruit;repository;Research;research data dissemination;Research Personnel;Resources;Role;Scholars Program;Scholarship;Science;Scientist;Series;Shapes;Site;social;social media;Social Processes;Study Section;symposium;Training;Translating;Translations;Universities;web site;Writing

PROJECT_TITLE: Center for Aging and Policy Studies (CAPS) Core D: External Research Resources Support and Dissemination Core


NIH_SPENDING_CATS: Cancer

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: Project Narrative Signal transduction is the process by which cells respond to environmental cues - networks of protein-protein interactions are coordinated by the reversible addition and removal of phosphate in response to the signal. Disruption of the normal patterns of phosphorylation has been implicated in the etiology of a variety of major human diseases, including cancer. The ability to modulate signaling pathways selectively holds enormous therapeutic potential. The first drugs directed against protein tyrosine kinases (PTKs) have now entered the market and represent breakthroughs in the treatment of cancer; however, challenges remain, including the fact that patients develop resistance to such drugs. Therefore, despite the obvious potential of PTK inhibitors as drug candidates, alternative approaches, to target simultaneously different signaling enzymes and events, are expected be more effective than focusing on PTKs alone. But what are those alternative approaches? The focus on PTKs for drug development ignores the other major component of phosphorylation-dependent regulation of signaling. Protein phosphorylation is a reversible process, in which the coordinated and competing activities of kinases and phosphatases are important for determining signaling outcome. The protein tyrosine phosphatases (PTPs), which work in combination with the PTKs, have been garnering attention as potential therapeutic targets, but remain a largely untapped resource for drug development. This proposal focuses on a functional analysis of specific PTPs in models of cancer. The hypothesis to be tested is that PTPs function as specific regulators of tyrosine phosphorylation-dependent signaling pathways and thus manipulation of PTP function in cell and animal models will reveal new insights into the critical signaling events that underlie the disease. The overall goal is to define functional links between particular PTPs and specific signaling pathways in cancer, with a view to establishing how disruption of such functions affects the etiology of the disease and to reveal novel therapeutic targets from among the PTPs themselves or from the signaling pathways they regulate. Furthermore, we have now developed new approaches to “drugging” the PTPs themselves, producing drug-like molecules that are opening up new opportunities for cancer therapy.

PI_NAMEs: TONKS, NICHOLAS K (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: acquired drug resistance;Active Sites;Acute Respiratory Distress Syndrome;Address;Affect;Animal Model;Architecture;Attention;Biological;C-terminal;Cancer Model;cancer therapy;Catalysis;Cell model;Cells;Charge;chemical property;Copper;Copper Chelation;COVID-19;Cues;cytotoxic;Data;Development;Disease;drug candidate;drug development;Drug resistance;drug resource;drug-like compound;Enzymes;Etiology;Event;Excision;extracellular;Family;Frustration;Funding;Generations;Goals;Grant;Growth;human disease;improved;Industry;inhibitor;innovation;inorganic phosphate;insight;interest;Link;Malignant Neoplasms;Marketing;Mass Spectrum Analysis;Mediating;member;Metabolism;Modeling;Movement;mutant;neutrophil;Neutrophil Activation;new therapeutic target;novel;novel strategies;Oncogenic;Outcome;Pathologic;Patients;Pattern;Pharmaceutical Preparations;phosphatase inhibitor;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Play;prevent;Process;programs;Proliferating;Protein Dephosphorylation;Protein Family;Protein Inhibition;protein protein interaction;Protein Tyrosine Kinase;Protein Tyrosine Phosphatase;Proteins;PTPN1 gene;Regulation;Resistance;Resistance development;response;Signal Pathway;Signal Transduction;Signal Transduction Pathway;small molecule;small molecule inhibitor;Stimulus;Structure;success;targeted treatment;Technology;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;transfusion related acute lung injury;Trastuzumab;Tumor Suppressor Proteins;Tyrosine;Tyrosine Kinase Inhibitor;Tyrosine Phosphorylation;Validation;Work

PROJECT_TITLE: Protein Tyrosine Dephosphorylation & Signal Transduction

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Diabetes;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Nutrition;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative South Asians are a rapidly increasing minority population in the U.S., Canada, and the U.K. This group has marked increase in premature heart disease and diabetes that is not fully explained by diet and lifestyle or traditional lipids. By understanding what might explain the increased heart and diabetes risk, we may better treat and prevent these conditions in South Asians.

PI_NAMEs: ROHATGI, ANAND KUMAR (contact)

PROGRAM_OFFICER_NAME: YAN, YE

PROJECT_TERMS: adiponectin;Adipose tissue;African ancestry;Anti-Inflammatory Agents;Antiatherogenic;Asian population;Atherosclerosis;atherosclerosis risk;Bangladesh;biobank;Black race;Blood Vessels;Body mass index;Calcium;Canada;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cardiovascular disorder risk;Cardiovascular system;Carotid Artery Plaques;Chinese;clinical biomarkers;cohort;Communities;coronary artery calcium;Diabetes Mellitus;diabetes risk;Diet;Diffuse;enhancing factor;Ethnic Population;European;Fatty acid glycerol esters;Functional disorder;Glucose Intolerance;Goals;Health Benefit;Heart;Heart Diseases;Hepatic;High Density Lipoproteins;high risk;Hispanic;Impairment;improved;India;Individual;insight;Insulin Resistance;insulin sensitivity;Intervention;Leptin;Life Style;Link;lipid metabolism;Lipids;Lipoproteins;Longitudinal cohort;Measures;Mediator;Metabolic;metabolic phenotype;Metabolism;metabolome;metabolomics;Minority Groups;Molecular Profiling;mortality;Multi-Ethnic Study of Atherosclerosis;National Heart, Lung, and Blood Institute;Nepal;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Observational Study;Outcome;Pakistan;Participant;Pathway Analysis;Pathway interactions;Pattern;Pericardial body location;Phenotype;Predisposition;premature;Prevalence;prevent;Prevention Guidelines;Proteomics;Public Health;recruit;resistin;reverse cholesterol transport;Risk;Risk Factors;Role;South Asian;specific biomarkers;Sri Lanka;subcutaneous;System;trait;Triglycerides;Validation;Very low density lipoprotein;Visceral;waist circumference

PROJECT_TITLE: Lipoprotein Metabolism and Excess Cardiometabolic Risk in South Asians

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ORG_CITY: MORGANTOWN

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative West Virginia (WV) ranks among the worst states in most indicators of health outcome, including stroke prevalence and its co-morbid conditions. To address these issues, the WVU Stroke CoBRE will continue to conduct basic and translational research to decrease morbidity and mortality related to stroke through improved understanding of pathophysiological mechanism(s) of stroke. This will be achieved through the development of stroke researchers at WVU by mentored research training and the expansion of cutting-edge research core facilities.

PI_NAMEs: DEVRIES, ANNE COURTNEY (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Acute;Address;aging population;American;Appalachian Region;Applications Grants;base;Basic Science;Behavior;behavior test;Biological Markers;Brain;Cardiovascular Diseases;Centers of Research Excellence;Chronic;Cognitive deficits;comorbidity;Core Facility;Data;design;Development;Diabetes Mellitus;disability;Disabling;Educational workshop;Extramural Activities;faculty mentor;Fees;Fostering;Functional disorder;Funding;global health;Goals;Grant;Health;health care availability;High Prevalence;high risk;Hypertension;improved;Individual;infection risk;innovation;Institution;Life Style;low socioeconomic status;Mental Depression;Mentors;Metabolic syndrome;Mitochondria;modifiable risk;Morbidity - disease rate;mortality;Motor;multidisciplinary;novel;Obesity;Outcome;Patient-Focused Outcomes;Patients;Phase;poor health outcome;Positioning Attribute;Prevalence;Prevention strategy;programs;Research;Research Personnel;Research Project Grants;Research Training;Resources;Risk Factors;Rodent;Rural Community;Sedation procedure;Sensory;Service delivery model;Services;Smoking;Social isolation;Stroke;stroke model;stroke recovery;stroke rehabilitation;stroke therapy;success;Tissue Banks;Training;Translational Research;Universities;West Virginia;Writing

PROJECT_TITLE: West Virginia University Stroke COBRE


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Stroke

PI_NAMEs: SIMPKINS, JAMES W. (contact)

PROJECT_TERMS: Achievement;Acute;Address;Advisory Committees;Agreement;Applications Grants;Appointment;Area;Award;Awareness;Cardiovascular system;career;career development;Centers of Research Excellence;Committee Members;Communities;comorbidity;Development;Disease;Educational workshop;Evaluation;expectation;Faculty;faculty mentor;Feedback;formative assessment;Fostering;Foundations;Free Will;Funding;Goals;Graduate Education;Grant;Health Sciences;Healthcare;innovation;Leadership;Link;meetings;Mentors;mid-career faculty;Monitor;Needs Assessment;Neurosciences;Paper;peer;Persons;Phase;Positioning Attribute;Preparation;programs;Publications;recruit;Recruitment Activity;Research;Research Activity;research and development;Research Personnel;Research Project Grants;Research Training;Resources;satisfaction;Schedule;Scientist;Series;sound;Stroke;stroke rehabilitation;success;synergism;tenure track;Universities;West Virginia;Writing


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Neurosciences;Stroke

PI_NAMEs: REN, XUEFANG SOPHIE  (contact)

PROJECT_TERMS: American;Animal Model;Applications Grants;Automobile Driving;Biomedical Research;Blood;Blood flow;Brain Injuries;Businesses;Cardiovascular system;Cause of Death;Centers of Research Excellence;Cerebrovascular Circulation;Communities;Consultations;Core Facility;cost;Data;design;Development;disability;effective therapy;Effectiveness;Equipment;Experimental Models;Fees;Funding;Gases;Goals;Health Sciences;Human Resources;Individual;Infarction;Institution;instrumentation;Ions;Measures;Mentors;Methods;migration;Modernization;Mus;Neurologic;Neurological outcome;Neurosciences;novel;Online Systems;Operative Surgical Procedures;Outcome;Performance;Phase;Philosophy;Positioning Attribute;post stroke;Procedures;Process;Production;Program Research Project Grants;programs;Protocols documentation;Rattus;Research;Research Personnel;Resources;Rodent;Rodent Model;Schedule;Secure;Services;Stroke;stroke model;stroke outcome;stroke therapy;success;Techniques;theories;tool;Training;Universities;West Virginia


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_DEPT: GENETICS

PHR: In this project we will focus on poorly studied noncanonical short RNAs, tRFs, that are generated by mechanisms very different from microRNAs and yet several of them are now known to enter into microRNA mediated gene regulatory machinery (RISC). This project will identify specific surveillance mechanisms that keep many tRFs out of RISC, mechanisms that can be altered in pathological conditions and for therapeutic purpose. In parallel, the project will study those tRFs that elude the surveillance mechanisms and enter RISC, to determine their effects on gene regulation, cellular phenotypes and microRNA mediated gene expression, thus significantly expanding our understanding of RNA mediated post-transcriptional gene regulation.

PI_NAMEs: DUTTA, ANINDYA  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Affect;Area;Attention;attenuation;Back;base;Biogenesis;Biological;Biological Markers;Cancer cell line;Cell Line;Cell Physiology;Cells;Complex;Disease;Enzymes;Family member;Gatekeeping;Gene Expression;Gene Expression Regulation;gene repression;Gene Silencing;Gene Silencing Pathway;Genes;Glioma;glioma cell line;Human;improved;Individual;Isocitrate Dehydrogenase;Link;Malignant Neoplasms;Mediating;member;Messenger RNA;Methyltransferase;MicroRNAs;Modeling;Modification;Mutation;Oncogenic;Organism;Pathogenicity;Pathologic;Pathway interactions;Phenotype;piRNA;Porifera;Post-Transcriptional Regulation;prevent;Process;Proliferating;Regulation;Repression;Ribonucleases;Ribosomal RNA;RNA;RNA Interference Therapy;RNA-Induced Silencing Complex;Role;Small Interfering RNA;Testing;Therapeutic;Transfer RNA;tumorigenesis;Work

PROJECT_TITLE: Involvement of Noncanonical Short RNAs in gene repression through the RNA-induced-silencing complex

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PUBLIC HEALTH RELEVANCE The generation of mental imagery is believed to be critical for cognition and mental health. This proposal will investigate the brain systems responsible for generating mental images and the role that mental images play in performing essential cognitive tasks.

PI_NAMEs: HERMES, DORA ;NASELARIS, THOMAS P (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Artificial Intelligence;Attention;Behavior;Brain;Cognition;cognitive function;cognitive task;comparative;Data;Disputes;distraction;Dorsal;expectation;experience;extrastriate visual cortex;Foundations;Frequencies;frontal eye fields;Functional Magnetic Resonance Imaging;Generations;Goals;Human;human subject;Image;image guided;Imagery;imaging detection;improved;Individual;innovation;Lateral;Link;Measures;member;memory recognition;mental function;Mental Health;mental imagery;Methods;Mind;Modeling;Nature;network models;Noise;novel;operation;Parietal;Pattern;Performance;Persons;Play;Psyche structure;public health relevance;Regulation;Reporting;Research;Retina;retinotopic;Role;Stimulus;System;targeted imaging;Task Performances;Techniques;Temporal Lobe;Testing;tool;Variant;Vision;Visual;Visual Cortex;Visual System;Work

PROJECT_TITLE: Seen and mental images in visual cortex


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Neurosciences;Stroke

PI_NAMEs: ENGLER-CHIURAZZI, ELIZABETH  (contact)

PROJECT_TERMS: Advisory Committees;Amendment;Applications Grants;Area;Articulation;Automation;Award;Behavior;Behavior assessment;behavior test;Behavioral;Behavioral Assay;Biomedical Research;Brain;Brain Diseases;Centers of Research Excellence;Charge;Communities;comorbidity;Computer software;Consultations;Core Facility;cost;Data;Data Collection;Dedications;design;Educational workshop;Equipment;Evaluation;Experimental Designs;Faculty;faculty support;Fees;functional outcomes;Funding;Growth;Human;improved;Institution;Instruction;instrumentation;Investments;journal article;Measures;Medical;Methods;Mission;Nervous System Disorder;novel therapeutic intervention;operation;Persons;Phase;post stroke;pre-clinical assessment;Pre-Clinical Model;Procedures;Productivity;programs;Publications;Publishing;Quality Control;Quality of life;Recommendation;recruit;Reproducibility;Research;Research Infrastructure;Research Personnel;Resources;Rodent;Role;Schedule;Services;Shoulder;Statistical Data Interpretation;Stroke;stroke therapy;Testing;testing services;Therapeutic Intervention;tool;Training;Universities;university student;Wages;West Virginia;Work;Writing