NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cerebrovascular;Neurosciences;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: The proposed research is relevant to public health because the development of novel imaging tools and models that reveal how cancer cells hijack (i.e. co-opt) pre-existing blood vessels in the brain will yield invaluable insight into brain cancer progression, tumor spread, and development of drug resistance. The proposed research is relevant to the NIH’s mission because the mechanism of vascular co-option in brain cancer remains poorly understood, and studying it in clinically relevant brain tumor models would help us understand how resistance to antiangiogenic therapies develops, and enable the identification of new biomarkers and treatment strategies for patients with brain cancer.

PI_NAMEs: PATHAK, ARVIND P (contact)

PROGRAM_OFFICER_NAME: GRODZINSKI, PIOTR

PROJECT_TERMS: 3-Dimensional;Angiogenesis Inhibitors;Animals;Astrocytes;Attenuated;awake;Biological Markers;biomarker identification;Blood Vessels;Brain;Brain Neoplasms;brain tissue;cancer cell;cellular engineering;Central Nervous System Diseases;cerebral blood volume;cerebral hemodynamics;Cerebrovascular system;Clinical;clinically relevant;Complement;connectome;contrast enhanced;Core-Binding Factor;Data;Data Set;Development;drug resistance development;Evolution;Exhibits;Fluorescence;Frequencies;Functional Magnetic Resonance Imaging;gene therapy;Glioblastoma;Glioma;gliovascular;Goals;Growth;hemodynamics;Histologic;Histology;Image;imaging approach;Imaging Device;in vivo;in vivo imaging;innovation;insight;Invaded;Lasers;Life Cycle Stages;Light;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Measurement;Metastatic malignant neoplasm to brain;meter;Methods;Microscopy;migration;miniaturize;Mission;Modeling;Morphology;Motivation;Multimodal Imaging;multimodality;multiscale data;Mus;neoplastic cell;Neurons;novel;novel marker;Optics;Patients;pre-clinical;predictive modeling;Public Health;Radiology Specialty;Recurrence;Research;Research Personnel;Resistance;Resolution;Rest;Signal Transduction;soft tissue;Specificity;Systems Biology;therapy development;treatment strategy;tumor;tumor progression;Tumor Volume;United States National Institutes of Health;Xenograft procedure

PROJECT_TITLE: Image-based Systems Biology of Vascular Co-option in Brain Tumors


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Fatigue Syndrome (ME/CFS);Chronic Pain;Mental Health;Neurosciences;Pain Research;Physical Activity

ORG_CITY: INCLINE VILLAGE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SIMMARON RESEARCH INC

ORG_STATE: NV

PHR: Project Narrative: Our current proposal identifies a novel molecular mechanism of atg13 deficiency in the pathogenesis of ME/CFS. Our study explores if tissue-specific knock-down of atg13 generates post-exertional malaise (PEM) pathology in mice.

PI_NAMEs: ROY, AVIK  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Ablation;Acute;Adopted;Afferent Neurons;Age;Agonist;anaerobic glycolysis;Anxiety;Apoptosis;Attention;Attentional deficit;Autonomic Dysfunction;Autophagocytosis;Blood Pressure;Brain;brain cell;Brain Stem;Calcium;Cardiopulmonary;Cells;Chronic;Chronic Disease;Chronic Fatigue Syndrome;chronic inflammatory disease;Clinical;Cognitive deficits;Computer software;Data;Demyelinations;Development;Disease;disease model;Dizziness;Drops;Energy Metabolism;Exercise;Exercise Test;Exertion;Exhibits;Fatigue;Female;FRAP1 gene;Genes;Growth;Hand Strength;Heart Rate;Homeostasis;Impaired cognition;Impairment;Inflammation;Inflammatory;Investigation;knock-down;Knock-out;Knockout Mice;lymph nodes;Malaise;Measurement;Measures;Mental Depression;Metabolic;Mitochondria;Mobility decline;Molecular;Molecular Analysis;Monitor;Mononuclear;motor impairment;mouse model;Mouse Strains;Mus;Muscle;Muscle Fatigue;Muscle Weakness;Mutation;Myalgia;neural;Neurocognitive Deficit;novel;orthostatic intolerance;Pain;Pathogenesis;Pathology;Pathway interactions;Patients;Peripheral;Peripheral Nervous System;Pharmaceutical Preparations;Play;Production;Proteins;Protocols documentation;RANTES;Regimen;Role;Running;Spinal Cord;Spinal Ganglia;Spleen;Stress;Symptoms;System;Tamoxifen;Testing;Th1 Cells;Tissues;treadmill

PROJECT_TITLE: ATG13: A new player in ME/CFS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CFS-N(80)S]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: PHYSICS

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE The successful moment-to-moment control of movement is contingent upon the function of complex neural microcircuits that reside outside the brain; understanding how these circuits function is critical to being able to treat age-related and developmental diseases in which these circuits are impaired. This proposal will leverage advantages of a highly tractable model system—the fruit fly—to determine how reflex circuits outside the brain enable successful movement and balance. Ultimately, elucidating the computational principles underlying these circuits will help inform our understanding of human circuits that must perform similar functions.

PI_NAMEs: COHEN, ITAI  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Acute;Age;age-related disease;Anatomy;Animals;Architecture;automated image analysis;base;Behavioral;Biological Models;Brain;Cells;Cephalic;Chronic;Complex;Congenital Disorders;design;developmental disease;Disease;Drosophila genus;Drosophila melanogaster;Equilibrium;experimental study;Feedback;fly;Flying body movement;Freedom;Functional Imaging;Grouping;Human;Impairment;Individual;innovation;Insecta;insight;Interneurons;kinematics;Knowledge;Link;Locomotion;Maps;Measurement;Mechanics;Modeling;Motor;motor behavior;motor control;Motor Neurons;Motor output;Movement;Muscle;Musculoskeletal Equilibrium;National Institute of Neurological Disorders and Stroke;Nature;Nerve;Nervous System;neural;neural circuit;Neurons;neuroregulation;novel;optogenetics;Output;Performance;Phase;Population;Reflex action;Reflex control;response;Role;Rotation;sensor;Sensory;sensory input;Spinal Cord;Stroke;Structure;Synapses;System;Techniques;Testing;Transgenic Organisms;transmission process;Trauma;Wing

PROJECT_TITLE: Determining Computational Principles Governing Neural Circuits Responsible for Feedback and Movement Control of D. Melanogaster Flight


ADMINISTERING_IC: AI

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: HOUGHTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MICHIGAN TECHNOLOGICAL UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative AAV therapy has shown tremendous success as a DNA delivery vector to treat and potentially cure many serious single gene disorders. To reduce the cost and increase the efficiency of manufacturing AAV vectors, we need to better understand the differences between viral capsids with and without genomes. This project will determine the structural changes in AAV capsids with and without genomes that could lead to improved production, quality control and safety of AAV therapy and help bring more lifesaving AAV therapies to market.

PI_NAMEs: HELDT, CARYN  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Address;adeno-associated viral vector;Affect;Amides;Amino Acids;Atomic Force Microscopy;Binding;Biological Models;Capsid;Capsid Proteins;Cells;Charge;Chemicals;Chemistry;cost;Data;delivery vehicle;Deuterium;DNA;DNA delivery;DNA Packaging;Dose;Drug Delivery Systems;Encapsulated;Future;Gene Transduction Agent;Genes;Genome;Genomic DNA;Hydrogen;Hydrophobic Surfaces;Hydrophobicity;immunogenicity;improved;innovation;insight;interest;large scale production;Life;Life Cycle Stages;Liver Dysfunction;Maintenance;manufacture;Maps;Marketing;Mass Spectrum Analysis;Measurement;Measures;Mechanics;Mendelian disorder;Methods;Minor;Molecular;Molecular Conformation;nanoindentation;novel;Nucleic Acids;particle;Patients;pressure;Process;Production;Property;protein protein interaction;Proteins;Quality Control;Reaction;Recombinant adeno-associated virus (rAAV);Research;Safety;scale up;side effect;Steroids;structural biology;Structure;success;Surface;Techniques;tissue tropism;Toxic effect;trafficking;Viral;Viral Packaging;Virus;Work

PROJECT_TITLE: Structural and chemical changes between empty and full AAV capsids

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Infertility;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE DNA methylation is known to change with age, and may be associated with declining ovarian reserve and oocyte function that occurs as women approach menopause. A better understanding of the genes and processes involved in reproductive aging would provide insight into the underlying etiology of reproductive aging and may allow for the development of treatments to slow or reverse aging. This project will provide focused training opportunities including in aging biology and mechanisms, reproductive aging, aging epigenetics, clinical and translational research, and career development that will help me achieve my goal of becoming an independent, NIH-funded investigator.

PI_NAMEs: KNIGHT, ANNA KAITLYN (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: accelerated epigenetic aging;Age;age acceleration;age related;age related changes;age related decline;age-related disease;Aging;aging reversal;Apoptosis;biobank;Biological;Biological Aging;Biological Process;Biology of Aging;Body System;career development;Cell Aging;cell type;Chronic Disease;Clinical Research;Data;design;Development;DNA Methylation;DNA Repair;Elderly;Embryo;Epigenetic age;epigenetic aging;epigenetic clock;Epigenetic Process;epigenome;epigenome-wide association studies;Etiology;experience;falls;Female;fertility preservation;Fertilization in Vitro;Foundations;Funding;Future;Genes;Genome;Goals;Gonadal Steroid Hormones;Grant;granulosa cell;hallmarks of aging;Health;Implant;Individual;innovation;insight;Life;Longevity;Maintenance;Manuscripts;Measures;Menopause;Metabolism;Methylation;methylation pattern;mullerian-inhibiting hormone;Mutation;oocyte quality;Oocytes;ovarian reserve;Ovarian Stimulations;Ovary;Participant;Pathway interactions;Pattern;Persons;Positioning Attribute;preservation;Process;Reporting;reproductive;reproductive senescence;Reproductive system;research and development;Research Personnel;Risk;Sampling;Site;success;Telomere Shortening;Testing;therapy development;Tissues;Training;training opportunity;Translational Research;United States National Institutes of Health;Woman;Work;Writing

PROJECT_TITLE: DNA methylation differences underlying female reproductive aging

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biotechnology;Genetics;Human Genome;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Heavy drinking and alcohol use disorder (AUD) are common, serious public health problems, both of which have a large genetic component. This project will integrate data from multiple genome-wide association studies of alcohol consumption and AUD with novel laboratory-based 3D Genomics-based methods to implicate effector genes contributing to these alcohol-related traits, and then validate them using a Drosophila model system and electronic health record data from existing biobanks. Using these innovative methods, the project will increase our understanding of the molecular genetics of alcohol-related traits and further prevention, diagnostic, and therapeutic efforts.

PI_NAMEs: GRANT, STRUAN F A;KAYSER, MATTHEW S;KRANZLER, HENRY RICHARD (contact)

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;African ancestry;Alcohol abuse;alcohol behavior;Alcohol consumption;alcohol effect;alcohol related gene;alcohol use disorder;Alcohols;ATAC-seq;Behavioral;binge drinking;biobank;Biological;Biological Models;Biological Process;Candidate Disease Gene;candidate identification;causal variant;Cells;Cessation of life;Chromatin;Chromosome Mapping;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;comorbidity;CRISPR/Cas technology;Data;data integration;Data Set;Development;Diagnosis;Diagnostic;dopaminergic neuron;Drosophila genus;Drosophila melanogaster;Electronic Health Record;Elements;Enhancers;Epigenetic Process;European ancestry;exome;fly;Gene Expression;Genes;Genetic;genetic architecture;genetic manipulation;genetic variant;genome wide association study;genome-wide;Genomics;Heavy Drinking;Heritability;Hi-C;human induced pluripotent stem cells;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;innovation;knock-down;Laboratories;Latino;Light;Link;Maps;Measures;Medical;Meta-Analysis;Methods;Modeling;Molecular Genetics;Neighborhoods;Neurons;Neurotransmitters;novel;novel strategies;Orthologous Gene;overexpression;Pathway Analysis;Pathway interactions;phenome;Phenotype;pleiotropism;Population;preference;Prevention;programs;promoter;psychosocial;Public Health;rare variant;Regulatory Element;Reporting;Resolution;Resources;risk variant;Sampling;Sequence Deletion;Single Nucleotide Polymorphism;System;Testing;Therapeutic;Time;trait;transcriptome sequencing;Twin Multiple Birth;Untranslated RNA;Variant;Veterans

PROJECT_TITLE: Leveraging GWAS Findings to Map Variants and Identify Novel Effector Genes for Alcohol-Related Traits

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Chronic Pain;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Intervertebral disc degeneration is strongly associated with low back pain, but the role of the intervertebral disc as the pain generator is not clear. We aim to investigate the role of vascular endothelial growth factor A in regulating the pathological in-growth of blood vessels and nerves in intervertebral discs during low back pain, and the molecular factors that govern the pathoanatomy. The improved understanding of these molecular events will help to develop therapies for treating low back pain.

PI_NAMEs: GUPTA, MUNISH ;TANG, SIMON YUE-CHEONG (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Abate;Ablation;Adult;afferent nerve;Afferent Neurons;Alleles;American;Analgesics;Anatomy;angiogenesis;Animals;Attenuated;behavior test;Behavioral Symptoms;bevacizumab;Blood Vessels;Cells;Chronic;Chronic low back pain;Clinical;Connective Tissue;contrast enhanced;cost;Data;Development;Disease;Embryo;Endothelial Cells;Enterobacteria phage P1 Cre recombinase;Etiology;Event;Excision;Experimental Designs;Exposure to;Foundations;Future;Goals;Growth;Healthcare;Human;Immunofluorescence Immunologic;improved;in vivo;inducible Cre;Infiltration;Inflammatory;Inflammatory Response;Injury;innovation;insight;Intervention;Intervertebral disc structure;intervertebral disk degeneration;Laboratories;Locomotion;Low Back Pain;Macular degeneration;Malignant Neoplasms;microCT;Molecular;Monitor;mouse model;Mus;neovascularization;Nerve;Nerve Growth Factors;nerve supply;neurite growth;Neurites;Neurons;Operative Surgical Procedures;Pain;pain behavior;pain symptom;Pathologic;Performance;persistent symptom;Play;postnatal;prevent;Prevention;Proliferating;Retroperitoneal Space;Rodent;Rodent Model;Role;social;Source;spinal disk injury;Spinal Ganglia;Structure;Symptoms;Tamoxifen;Therapeutic;therapy development;Tissues;Ubiquitin;Vascular Endothelial Growth Factors;Vascularization;Vegf inhibition;VEGFA gene;Work

PROJECT_TITLE: The Role of VEGF in the Development of Low Back Pain Following IVD Injury

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Health Services;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: BARRON ASSOCIATES, INC.

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed EMPATHIE system is an innovative educational game environment that leads students through lesson modules to introduce science concepts using an immersive and engaging platform. The EMPATHIE system will enhance STEM education by: (1) providing novel and exciting STEM content through science lessons and a unique electromyography game interface; (2) ensuring lessons are engaging and relevant to students from under-represented groups by including them in game development through a participatory design process; and (3) incorporating design thinking concepts with a focus on developing empathy by placing students in the role of a patient dealing with daily challenges.

PI_NAMEs: KREPKOVICH, EILEEN T. (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Architecture;Award;Awareness;Biological Sciences;career;computer science;Computer software;design;Development;digital media;disorder control;Education;Electromyography;Empathy;engineering design;Ensure;ethnic minority;Evaluation;evidence base;experience;feasibility testing;Feedback;Fostering;game development;gaming environment;girls;Goals;Health Personnel;Health Sciences;Healthcare;Healthcare promotion;improved;innovation;inquiry-based learning;Instruction;interest;junior high school;K-12 student;Learning;Learning Module;mathematical learning;mathematics content;Medical;Middle School Student;minority student;Modeling;Modernization;Motion;motor control;Motor disability;Muscle;new technology;novel;Patients;Performance;personalized learning;Phase;Physical Education;physical science;Play;Population;Problem Solving;Process;programs;prototype;Public Health;racial minority;Research;Role;Science;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;sensor;Small Business Innovation Research Grant;Societies;socioeconomics;Software Design;STEM field;student participation;Students;System;teacher;Teacher Professional Development;Technology;Testing;theories;Thinking;tool;Underrepresented Populations;Underrepresented Students;Update;usability;user centered design;Video Games;wireless;Work;Workplace

PROJECT_TITLE: Educational Media to Promote healthcare Awareness through an Immersive Experience (EMPATHIE)


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BOSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Innate defense responses to pathogens must be tightly regulated to avoid the tissue damage caused by their overactivation. In this study, we will investigate the role of proteolytic processing in innate defense regulation. Consistent with the NIH mission, this research will 1) generate new insights into the regulation of defense mechanisms and 2) reveal proteases that could serve as both potential biomarkers and therapeutic targets for diseases involving dysregulated innate defense responses.

PI_NAMEs: SAEED, MOHSAN  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acetylation;Award;cell growth regulation;Cells;Defense Mechanisms;defense response;design;Development;Disease;Environment;experience;Functional disorder;Goals;Human;improved;Innate Immune Response;insight;Invaded;Investigation;Knowledge;Label;microbial;microbial disease;Mission;Molecular Biology;N-terminal;Organ;pathogen;Pathway interactions;Peptide Hydrolases;Performance;Phosphorylation;Post-Translational Modification Site;Post-Translational Protein Processing;potential biomarker;Process;Proteins;Proteolysis;Proteolytic Processing;Regulation;Research;Resolution;Role;Signal Transduction;Site;Systems Biology;therapeutic target;Tissues;Toxin;Ubiquitination;United States National Institutes of Health;Viral

PROJECT_TITLE: Defining the role of site-specific proteolysis in innate defense signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Hearing Loss;Neurosciences;Rare Diseases;Usher Syndrome

ORG_CITY: OMAHA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: PROJECT NARRATIVE The perception of our surrounding environment depends on proper sensory organ function. Mutations in Pcdh15 affect the function of hair cells and photoreceptors resulting in deafness and progressive retinitis pigmentosa. The involvement of an integrin in the formation of a functional complex with Pcdh15 in hair cells has never been described. This proposal tests the hypothesis of a key role for Pcdh15-Itga8 complex in inner ear development and function, through Yap/ERM proteins activation and cytoskeletal dynamics. This work will define a common mechanism for Pcdh15-Itga8 complex in ear with the corresponding implications for Usher syndrome pathology.

PI_NAMEs: ZALLOCCHI, MARISA L. (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Address;Adult;Affect;American;Animals;Apical;Architecture;base;Biological Process;Biomechanics;Cell Maturation;Cell Physiology;cell type;Cells;Cochlea;Communities;Complex;conditional knockout;COVID-19 pandemic;Cues;Cytoskeleton;Data;Deafblind;deafness;Defect;defined contribution;Deposition;Development;Disease;Disease Progression;Ear;Elements;Environment;Equilibrium;Extracellular Matrix;ezrin;Fishes;Genetic;Genetic Diseases;Hair Cells;Hearing;hearing impairment;High-Frequency Hearing Loss;Human Genetics;inner ear development;Integrin alpha Chains;Integrins;Ion Channel;Kinocilium;Knockout Mice;Laboratories;Labyrinth;Link;mature animal;Membrane;moesin;Molecular;Molecular Target;Morphology;Mus;mutant;Mutation;Neurons;neurosensory;Noise;noise exposure;novel;Organ;Organ of Corti;Organism;Outer Hair Cells;Pathology;Pathway interactions;PCDH15 gene;Perception;Phenotype;Photoreceptors;Positioning Attribute;progressive hearing loss;protein activation;Proteins;Publishing;radixin protein;receptor;Retina;Retinitis Pigmentosa;ribbon synapse;Role;sensor;Sensory;Signal Pathway;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;small molecule;Social Distance;spiral ganglion;Structure;Supporting Cell;temporal measurement;Testing;Time;Tissues;Touch sensation;transcriptome sequencing;Usher Proteins;Usher Syndrome;Work;Zebrafish

PROJECT_TITLE: Identification and characterization of novel functions for the Usher proteins in the inner ear


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The resistance to current AR targeted therapies is one of the biggest challenges when treating advanced prostate cancer and largely hinders the clinical outcome of patients with this deadly disease. This study aims to determine the molecular role of a new potential tumor suppressor in prostate cancer, SYNCRIP, in suppressing APOBEC- mediating mutagenesis and resistance to AR targeted therapies. Elucidating the role of this protein and the molecular mechanism of the resistance may identify new actionable targets and establish a pathway for the development of therapeutic approaches to overcome the resistance and ultimately benefit patients.

PI_NAMEs: MU, PING  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: advanced prostate cancer;Affect;American;androgen independent prostate cancer;apoB mRNA editing catalytic subunit;Apoptosis;Automobile Driving;Binding;cancer diagnosis;cancer initiation;Cancer Patient;Castration;Cell Proliferation;Cells;Clinical;Cytoplasm;Data;Deaminase;Dependence;Disease;DNA;DNA Sequence Alteration;enzalutamide;Genes;genetic testing;Genetically Engineered Mouse;Genomics;Human;Impairment;improved;In Vitro;in vitro Model;in vivo;insight;knock-down;Knock-out;Libraries;Malignant neoplasm of prostate;Mediating;men;Messenger RNA;Molecular;mouse model;Mus;Mutagenesis;Mutate;neoplastic cell;novel;Oncogenes;Oncogenic;Organoids;Outcome;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;prostate cancer cell;prostate cancer cell line;prostate cancer model;Proteins;Reporting;Resistance;resistance mechanism;Resolution;response;RNA-Protein Interaction;Role;screening;senescence;Signal Pathway;synaptotagmin;targeted treatment;therapeutic development;therapeutic target;therapy resistant;treatment response;tumor;tumor growth;tumor heterogeneity;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;Work;Xenograft Model

PROJECT_TITLE: Elucidating the Molecular Role of SYNCRIP in Prostate Cancer and AR Targeted Therapy Resistance

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative This training program comes from MIT researchers working at the interface of science and engineering. Using and developing state-of-the-art technology, the trainees address cutting edge problems in environmental health. Our approaches involve measurement of risk, mining of complex biological data, modeling of systems exposed to environmental agents, and manipulation of systems to modulate risk.

PI_NAMEs: ESSIGMANN, JOHN M (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: environmental toxicology;Grant;Training

PROJECT_TITLE: Training Grant in Environmental Toxicology

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


NIH_SPENDING_CATS: Aging;Clinical Research;Health Services

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The objective of the Yale Training Program in Geriatric Clinical Epidemiology and Aging-Related Research is to develop a cadre of physician scientists and PhD investigators (clinicians and nonclinicians) with expertise in geriatric clinical epidemiology and/or translational aging research who will be equipped to address the myriad of unanswered questions concerning the diagnosis, etiology, treatment, prevention, and prognosis of the health problems experienced by the ever-increasing number of older persons.

PI_NAMEs: GILL, THOMAS MICHAEL (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: aging related;clinical epidemiology;Elderly;Research;Training Programs


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases;Neurosciences;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Project Narrative Ocular HSV-1 infection results in establishment of latent HSV infection and subsequent reactivation. Because recurrent virus reactivation remains a significant health concern, control of reactivation is an important goal in reducing HSV-associated eye disease. We will (i) test a highly innovative model based on our identification of two novel regions that upregulate HSV HVEM receptor and promote reactivation; and (ii) test strategies to block these interactions and reduce eye disease.

PI_NAMEs: GHIASI, HOMAYON  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Affect;Afferent Neurons;Apoptosis;Binding;Blindness;Cell surface;Cells;Clinical;clinically relevant;clinically significant;Data;Developed Countries;Development;exhaustion;Eye diseases;Eye Infections;Funding;Genes;Glycoproteins;Goals;Health;Herpesvirus 1;herpesvirus entry mediator;Herpetic Keratitis;Human;Immune Evasion;in vivo;Infection;innovation;insight;latency associated transcript;Link;Maps;Mediating;Mediator;member;Modality;Modeling;Molecular Target;mouse model;Mus;Neurons;new therapeutic target;novel;Oryctolagus cuniculus;Pathway interactions;Persons;Play;prevent;Primary Infection;Productivity;promoter;Proteins;Publishing;reactivation from latency;receptor;recombinant virus;Recombinants;Recurrence;Recurrent disease;Regulation;response;RNA;Role;simplexvirus receptor;Structure of trigeminal ganglion;Testing;TNF gene;Transcript;Untranslated RNA;Up-Regulation;Validation;Viral;Viral Genome;Virus

PROJECT_TITLE: Ocular HSV: Mechanism of virus reactivation

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative The objective of the proposed project is to enable new research into human neuromotor control, adaptation, and learning by providing an accessible, effective vehicle for the study and rehabilitation of balance and gait through the development of portable robotic footwear, which can modify foot-ground stiffness during locomotion. This research is critically relevant to public health because it is expected to yield new technology and evidence-based research to improve the diagnosis, assistance, and retraining of gait and balance impairments in real-world contexts, addressing persistent shortcomings in current methodologies. As such, this research is relevant to the National Institutes of Health and National Institute of Biomedical Imaging and Bioengineering mission of accelerating development of new biomedical technologies to advance basic research and medical care.

PI_NAMEs: HOOGKAMER, WOUTER ;HUBER, MEGHAN E (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Acceleration;Address;Age;age related;Area;Award;Basic Science;Behavior;behavior change;Behavioral;Biomechanics;Biomedical Technology;Caring;Clinical;clinical practice;Clinical Research;Data;design;Development;Devices;Diagnosis;Diagnostic;dynamic system;Early Diagnosis;equilibration disorder;Equilibrium;evidence base;experimental analysis;falls;Feedback;foot;Functional disorder;Gait;Gait abnormality;gait rehabilitation;Goals;Human;improved;Individual;innovation;insight;invention;kinematics;Knowledge;Laboratories;Lead;Learning;light weight;Locomotion;Long term disability;Measurement;Measures;Mechanics;Medical;Methodology;Methods;Mission;Modeling;Motion;Motor;motor behavior;motor learning;Multiple Sclerosis;Muscle;Musculoskeletal Diseases;National Institute of Biomedical Imaging and Bioengineering;neural;neuroadaptation;Neurodegenerative Disorders;Neurologic;Neuromechanics;neuroregulation;new technology;normal aging;novel;Parkinson Disease;Participant;Pathology;Performance;Peripheral;Pilot Projects;portability;preventive intervention;Public Health;Quality of life;Reaction;recruit;Rehabilitation device;rehabilitation paradigm;Rehabilitation therapy;Reporting;Research;Research Personnel;Resistance;response;robotic device;Robotics;Safety;Scientific Advances and Accomplishments;sensor;Series;Shoes;Signal Transduction;Specific qualifier value;Stroke;Surveys;System;Testing;Time;tool;Training;transmission process;treadmill;United States National Institutes of Health;usability;Validity and Reliability;Walking;wearable device;Weight-Bearing state;Work

PROJECT_TITLE: Portable, robotic footwear for real-time control of foot-ground stiffness

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Chronic myelomonocytic leukemia (CMML) is an aggressive blood cancer with limited treatment options. This project focuses on “proliferative” CMML variants, an aggressive CMML subtype, testing the safety and efficacy of Onvansertib, a novel and oral PLK1 inhibitor in relapsed refractory patients. The Phase 1 clinical trial Is accompanied with detailed laboratory work identifying predictors of response and resistance.

PI_NAMEs: PATNAIK, MRINAL SHIV (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Acute Myelocytic Leukemia;Apoptosis;biobank;Biological Assay;Biology;biomarker driven;Body Weight Changes;Bone Marrow;CBL gene;Cell Death;Cell Proliferation;Cells;Chronic Myelomonocytic Leukemia;Classification;Clinical;clinical efficacy;Clinical Trials;Code;cohort;combinatorial;Combined Modality Therapy;Data;design;Development;Disease;Dose;Down-Regulation;Drug Kinetics;effective therapy;Epigenetic Process;Event;Foundations;Frequencies;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic variant;genome-wide;Genotype;Hematologic Neoplasms;Hematopoietic Neoplasms;Histologic;Hour;Hypersensitivity;In Vitro;in vivo;in vivo Model;Individual;inhibitor;innovation;Knockout Mice;KRAS2 gene;Laboratories;leukemic transformation;Maximum Tolerated Dose;MEKs;Mitosis;Mitotic Checkpoint;Mitotic spindle;MLL gene;Mononuclear;mutant;Mutation;Myeloproliferative disease;NF1 gene;novel;novel therapeutic intervention;Oncogenic;Oral;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;Peripheral Blood Mononuclear Cell;personalized therapeutic;pharmacologic;Phase I Clinical Trials;phase I trial;phase II trial;Phosphorylation;Phosphotransferases;PLK1 gene;predicting response;progenitor;Proteins;PTPN11 gene;RAF1 gene;Recommendation;Refractory;Regulation;Relapse;Research;Resistance;response;Risk;RNA Interference;RNA interference screen;Role;Safety;safety testing;Sampling;Seminal;Signal Transduction;Spleen;survival outcome;synergism;targeted treatment;therapeutic target;Time;Toxic effect;TPT1 gene;transcriptome sequencing;transcriptomics;treatment strategy;tumor growth;Variant;White Blood Cell Count procedure;Work;Xenograft procedure

PROJECT_TITLE: Targeting PLK1 in RAS mutant chronic myelomonocytic leukemia

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Hematology;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative Red blood cells, the most numerous cell in the body, need to be replenished throughout life. We recently discovered that the hormone erythropoietin, which is essential for the process of red blood cell formation, induces extremely fast rates of protein synthesis during a specific stage of red blood cell formation. This proposal investigates the fundamental pathways that allow erythropoietin signaling to induce such a fast rate in protein synthesis, and may have implications for our understanding of cancer and for diseases with ribosomal protein mutations (ribosomopathies).

PI_NAMEs: SOCOLOVSKY, MERAV  (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Address;attenuation;Back;Biogenesis;Biomass;Bone Marrow;Cell Cycle;Cell division;Cell Enlargement;Cell Lineage;Cell Size;Cells;CFU-E;Compensation;Complex;Cues;Cytokine Receptors;Data;Development;Diamond-Blackfan anemia;Disease;Embryo;Erythroblasts;Erythrocytes;Erythroid;erythroid differentiation;Erythropoiesis;Erythropoietin;Fetal Liver;FRAP1 gene;Genes;Genetic;Genetic Transcription;Growth;Growth Factor;Hematopoiesis;Hemoglobin;Hormones;Housekeeping;Human;Insulin Receptor;interest;Knowledge;Life;Link;Malignant Neoplasms;Mammalian Cell;Measures;Mediating;Mediator;member;Modeling;Mus;Mutation;novel;Nutritional;overexpression;Pathway interactions;pharmacologic;Phosphotransferases;PIK3CG gene;pressure;Process;progenitor;Protein Biosynthesis;Protein Synthesis Induction;Proteins;Proteome;Proto-Oncogene Proteins c-myc;Publishing;Receptor Protein-Tyrosine Kinases;Regulation;Ribosomal Proteins;Ribosomal RNA;Ribosomes;ribosomopathy;S phase;self-renewal;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Speed;Testing;Time;Transcript;transcriptomics;Translating;Translations;Work

PROJECT_TITLE: EpoR & Stat5 regulation of ribosome biogenesis and protein synthesis in erythropoiesis


NIH_SPENDING_CATS: Lung;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_DEPT: NEUROSCIENCES

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative / Relevance A majority of human spinal cord injury (SCI) cases occur in the cervical region, resulting in persistent respiratory dysfunction that is associated with mortality, morbidities such as respiratory infections, and greatly reduced quality of life. Cervical SCI disrupts the neural circuitry that controls the diaphragm (the major muscle of inspiratory breathing); however, axon regeneration and consequent restoration of this critical circuitry do not occur following SCI, resulting in persistent respiratory compromise. In animal models of cervical SCI, we will evaluate strategies aimed at promoting reconnection of this highly-important neural circuitry for restoring diaphragmatic respiratory function.

PI_NAMEs: LEPORE, ANGELO C (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Address;Animal Model;antagonist;Automobile Driving;Axon;axon growth;axon regeneration;Axotomy;Behavior;Biological Assay;blood-brain barrier permeabilization;Brain Stem;Breathing;Cells;Cervical;Cervical spinal cord injury;Cervical spinal cord structure;Clinical;Contusions;Coughing;Coupled;Data;Denervation;Dependence;Distal;Dorsal;Fiber;functional improvement;functional restoration;Genetic;genetic approach;Goals;gray matter;Human;in vivo;Individual;Injections;injury and repair;innovation;Interneurons;Lesion;Location;Mechanical ventilation;Medial;Mediating;Modeling;Morbidity - disease rate;mortality;Motor;Motor Neurons;Muscle;Natural regeneration;nerve supply;neural circuit;Neuroanatomy;neuronal circuitry;Neurons;novel;Output;Pathway interactions;Peptides;Play;Population;PTEN gene;Quality of life;Recovery;Recovery of Function;recruit;regenerative approach;reinnervation;Respiration Disorders;respiratory;Respiratory Diaphragm;Respiratory Paralysis;Respiratory physiology;Respiratory Tract Infections;response;restoration;Role;Signal Transduction;Spinal;Spinal Cord;Spinal Cord Contusions;Spinal cord injury;Therapeutic;Therapeutic Intervention;translational potential;vector;ventilation;Viral;Viral Vector;Work

PROJECT_TITLE: Respiratory interneuron circuit plasticity: promoting recovery of diaphragm function after spinal cord injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Psychosis;Rehabilitation;Schizophrenia;Serious Mental Illness

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Approximately 25 to 50% of persons with schizophrenia are “treatment-resistant” failing treatment with adequate trials of 2+ antipsychotics plus clozapine and have persistent hallucinations that have been related to suicide, aggressive behaviors and poor functioning. The proposal seeks to use deep brain stimulation or DBS to treat hallucinations in schizophrenia.

PI_NAMEs: CASCELLA, NICOLA G (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Acute;Aggressive behavior;Antipsychotic Agents;Auditory;Auditory Hallucination;Basal Ganglia;Behavioral;Bilateral;Brain;Brief Psychiatric Rating Scale;Chronic;Clinic;Clinical;Clinical Research;Clozapine;Cognitive;cohort;connectome;conventional therapy;Data;Deep Brain Stimulation;design;Development;Diffusion Magnetic Resonance Imaging;Disease;Disease remission;Distress;Double-Blind Method;Ecological momentary assessment;effective therapy;Electroencephalography;Enrollment;follow-up;Hallucinations;Home;Image;Impairment;implantation;improved;inhibitory neuron;Ketamine;Lead;Left;Lesion;Link;Measurement;Measures;Medial Dorsal Nucleus;Mediating;Methods;Microelectrodes;Modeling;motor impairment;neuroimaging;neuromechanism;neurophysiology;neuropsychiatric disorder;Obsessive-Compulsive Disorder;Operative Surgical Procedures;Parkinson Disease;Pathologic;Patients;Persons;Phase;Phase I Clinical Trials;Public Health;Quality of life;Rattus;Refractory;Resistance;Saccades;safety study;Sample Size;Schizophrenia;Sensory;Serious Adverse Event;Speech;Substantia nigra structure;suicidal behavior;suicidal risk;Suicide;Superior temporal gyrus;Symptoms;System;Techniques;Thalamic structure;Tissues;tractography;Verbal Auditory Hallucinations;Work

PROJECT_TITLE: Deep Brain Stimulation for Chronic Auditory Hallucinations in Treatment-Resistant Schizophrenia: an early-stage clinical trial


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Pancreatic cancer is a deadly malignancy, with poor prognosis for patients at all stages of diagnosis. In this proposal, we will investigate novel roles for GLI transcription factors, the effectors of the Hedgehog signaling pathway, as key regulators of the pancreatic cancer microenvironment. Specifically, we will: 1) employ novel genetic approaches to assess the contribution of GLI transcription factors to pancreatic cancer progression, 2) elucidate GLI-dependent fibroblast-immune crosstalk and 3) define GLI transcriptional targets in pancreatic fibroblasts to positively impact the treatment of pancreatic cancer.

PI_NAMEs: ALLEN, BENJAMIN  (contact);PASCA DI MAGLIANO, MARINA

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Advanced Development;Alleles;Biological Assay;Cancer Etiology;cancer therapy;Cell Line;cell motility;Cells;Cessation of life;Chromatin;Clinical Trials;Cre driver;Data;Diagnosis;Disease;Disease Progression;effective therapy;Epitopes;Erinaceidae;Family;Fibroblasts;Genetic;genetic approach;Genetic Models;Genetic Transcription;GLI gene;Glioma;Growth;Health;Human;Immune;improved;In Vitro;in vivo;Incidence;Individual;inhibitor;Knock-in;Laboratories;Ligands;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Migration Assay;mouse model;Mus;Neoplasm Metastasis;novel;Organoids;Pancreas;pancreatic cancer model;pancreatic neoplasm;paracrine;Pathway interactions;patient prognosis;pharmacologic;Primary Neoplasm;Proteins;Regulation;RNA;Role;Signal Transduction;Signaling Protein;smoothened signaling pathway;Speed;Survival Rate;T cell infiltration;T-Lymphocyte;Testing;transcription factor;Transcriptional Regulation;transplant model;Transplantation;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor-Derived;United States;Work

PROJECT_TITLE: Investigating GLI transcription factors as regulators of the pancreatic cancer microenvironment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-W(80)S]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Rural Health;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE Low health literacy patients are a vulnerable population at high-risk for surgical disparities including longer hospital stays, more complications, and more readmissions. This study will adapt enhanced recovery programs (ERPs) to low health literacy patients with a multilevel, health literacy-based implementation strategy (VISACT) to improve ERP fidelity and thereby outcomes. Findings from this study will lay the foundation for a multi- institutional stepped-wedge trial and establish key principles for adapting interventions to eliminate disparities.

PI_NAMEs: CHU, DANIEL I (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;Adult;Affect;Alabama;Area;Attitude;black patient;Colorectal Surgery;Communication;Data;Databases;Deep South;design;Disparity;disparity elimination;disparity reduction;experience;Foundations;Goals;Health;health assessment;Health Care Costs;health communication;health literacy;high risk;hospital readmission;implementation fidelity;implementation framework;implementation science;implementation strategy;improved;improved outcome;in vivo;innovation;Institution;Intervention;Interview;Knowledge;Length of Stay;literacy;literate;low health literacy;Machine Learning;Maintenance;Measures;medical specialties;Methods;Mission;Modeling;National Institute on Minority Health and Health Disparities;Needs Assessment;novel;Nurses;older patient;Operative Surgical Procedures;Organization administrative structures;Outcome;Pathway interactions;patient engagement;Patient-Focused Outcomes;Patients;Perioperative Care;Pilot Projects;pilot test;poor health outcome;Population;Process;programs;Provider;provider communication;racial disparity;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;readmission risk;Recovery;recruit;Registries;Research;response;Rural;rural patients;Science;Site;Standardization;Structure;surgery outcome;surgical disparities;Surveys;Techniques;Testing;theories;Training;United States;United States National Institutes of Health;vision science;Visual Aid;Vulnerable Populations;Work

PROJECT_TITLE: Adapting Enhanced Recovery Programs (ERPs) through Health Literacy to Eliminate Surgical Disparities

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases;Regenerative Medicine

PHR: Wnts are a large family of signaling molecules with potent and widespread biological effects in the skeleton as well as development in general, stem cell maintenance, tissue homeostasis and cancer. This project will not only unravel how the structure of Wnt5a protein impacts signaling at the molecular and genetic levels, it will also shed light on the actions of other Wnt family members in diverse biological and disease processes. The fundamental knowledge gained from this project will help to elucidate pathogenic mechanisms in ADRS and provide crucial insight into the design of therapeutic interventions to treat skeletal disorders related to perturbation of Wnt/PCP signaling and be used to harness the power of Wnts for regenerative medicine.

PI_NAMEs: SERRA, ROSA A.;WANG, JIANBO  (contact)

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Amino Acids;autosome;Binding;Biochemical;Biochemistry;Biological;Biological Assay;Biophysics;Cell Maintenance;Complex;congenital skeletal disorder;convergent extension;Cysteine;Cysteine-Rich Domain;Data;Defect;design;Development;Digit structure;Dimerization;Disease;Distal;disulfide bond;Dose;Dwarfism;Engineering;Etiology;Family;Family member;Foundations;Frizzled Domain;Future;gain of function;Genetic;Genetic study;Homeostasis;Human;insight;Knowledge;Ligand Binding;Ligands;Limb Bud;Limb Development;Limb structure;long bone;Malignant Neoplasms;Mammals;Measures;Mediating;Modeling;Molecular;Morphogenesis;morphogens;mouse genetics;Mus;mutant;Mutation;N-terminal;Natural regeneration;Nature;Osteogenesis;Output;Pathogenesis;Pathogenicity;Pathway interactions;Pattern;planar cell polarity;predictive modeling;Process;Property;Protein Isoforms;Proteins;receptor;Regenerative Medicine;Robinow syndrome;Role;Series;Signal Transduction;Signaling Molecule;skeletal;Skeletal Development;skeletal disorder;skeletal dysplasia;skeletal regeneration;Skeletal system;Skeleton;stem cells;structural biology;Structure;Syndrome;Testing;Therapeutic Intervention;Thumb structure;Tissues;Transgenes;Transgenic Mice;Variant;WNT5A gene;WNT5A protein;Xenopus

PROJECT_TITLE: Mechanism of Wnt5a signaling in skeletal development and diseases

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Hematology;Orphan Drug;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The goal of this study is to inform the understanding of how therapy related myeloid neoplasia (TMN) develops in women with ovarian cancer in order to develop strategies to monitor and prevent this deadly secondary malignancy. We will enroll and serially follow ovarian cancer survivors with and without clonal hematopoiesis to define risk factors, kinetics, and genetic determinants of progression to TMN.

PI_NAMEs: SWISHER, ELIZABETH MARY (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Age;age related;Alleles;Biology;Blood;Blood Cells;Blood specimen;BRCA1 gene;BRCA2 gene;cancer genetics;Cancer Patient;Cancer Survivor;cancer therapy;cancer type;Cells;chemotherapy;Chromosome abnormality;Clinical;clinical diagnosis;Clonal Evolution;Clonal Expansion;Collection;Complex;cost;Country;cytotoxic;Cytotoxic Chemotherapy;Data;Development;Diagnosis;Disease;Dose;driver mutation;drug maintenance;Dysmyelopoietic Syndromes;Early Diagnosis;Early Intervention;Enrollment;Exposure to;Gene Frequency;Genes;Genetic;Genetic Determinism;genetic variant;genome integrity;Germ Lines;Germ-Line Mutation;Goals;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;Hematopoietic Neoplasms;improved;improved outcome;Incidence;Individual;induced pluripotent stem cell;inhibitor therapy;insight;Intervention;Karyotype;Kinetics;Learning;leukemia;Leukocytes;Life;Maintenance;Maintenance Therapy;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Marrow;Measures;Modeling;Molecular Abnormality;Monitor;Mutate;Mutation;Mutation Analysis;Myelogenous;Myeloid Cells;Myeloproliferative disease;Neoplasms;neoplastic;Non-Malignant;normal aging;novel;Oncogenic;Oral;Pathogenicity;patient subsets;Patient-Focused Outcomes;Patients;Persons;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Precancerous Conditions;Predisposition;Prevalence;prevent;Prevention;primary outcome;Prognosis;prospective;Prospective Studies;Radiation therapy;Recording of previous events;Reporting;response;Risk;Risk Factors;risk minimization;risk mitigation;Second Primary Cancers;Secondary Prevention;Selection for Treatments;Signal Transduction;Solid Neoplasm;stem cell model;surveillance strategy;Survivors;Susceptibility Gene;therapy development;therapy outcome;Time;Tobacco use;Toxic effect;TP53 gene;transcriptome;treatment optimization;Treatment-related toxicity;Woman;women's diagnosis

PROJECT_TITLE: Clonal hematopoiesis and therapy-emergent myeloid neoplasms in patients with ovarian cancer


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences;Pediatric;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Deficits in skilled reading ability contribute substantially to poor functional outcome in schizophrenia. The present study investigates both consequences and causes of impaired reading ability in schizophrenia.

PI_NAMEs: JAVITT, DANIEL C. (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Acceleration;Alcohol consumption;Assessment tool;Auditory;auditory processing;Auditory system;Behavioral;Biological Markers;Clinical;Clinical Management;Cognition;Computer Models;Contrast Sensitivity;Data;Development;Disease;Early Diagnosis;Education;eighth grade;eleventh grade;Employment;Evaluation;Event-Related Potentials;Eye Movements;Family;first episode schizophrenia;follow-up;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;functional outcomes;Future;gaze;Generations;high risk;high risk population;high school;Human Resources;imaging approach;Impaired cognition;Impairment;improved;indexing;Individual;information processing;Intervention;Intervention Studies;Investigation;Language;lexical;literacy;Literacy Programs;Measures;Mediating;Mediation;Mental Health;method development;Methods;Modeling;motion sensitivity;Multimodal Imaging;multimodal neuroimaging;multimodality;Nerve Degeneration;neurodegenerative phenotype;neuromechanism;New York;Occupational;oculomotor;Onset of illness;Outcome;Outcome Study;Patient Recruitments;Patients;Pattern;Pharmaceutical Preparations;phonology;Population;Population Control;Prevalence;Process;programs;prospective;Quality of life;Reader;Reading;reading ability;reading difficulties;recruit;remediation;Role;Saccades;sample fixation;Schizophrenia;School-Age Population;Schools;screening program;Sensory;sensory integration;service utilization;Services;side effect;skills;social;social cognition;social determinants;Societies;Stimulus;success;Symptoms;Testing;Text;Training Programs;Visual;visual information;visual tracking;Work

PROJECT_TITLE: Neural Mechanisms of Reading Dysfunction in Schizophrenia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: KANSAS CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative  Mitochondrial dysfunction and failure of mitochondrial degradation pathways (mitophagy) are observed in Alzheimer’s diseases (AD) and likely contribute to pathogenesis. Amyloid precursor protein (APP) localizes to mitochondria and affects mitochondrial and mitophagy function. We will directly test the relationship between APP, mitophagy, and mitochondrial function.

PI_NAMEs: WILKINS, HEATHER M. (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Abeta synthesis;Affect;Alzheimer's Disease;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid precursor protein processing;Animal Model;Astrocytes;Autophagosome;Bioenergetics;cell type;Cells;Clinical Trials;Data;Degradation Pathway;DNA copy number;Drug Design;drug discovery;Electron Microscopy;Electron Transport;Engineering;experimental study;Failure;fatty acid oxidation;Genes;Goals;Impairment;in vitro Model;in vivo;in vivo Model;induced pluripotent stem cell;knock-down;Knock-out;Knockout Mice;Knowledge;Label;Length;Literature;Measures;Membrane Potentials;Metabolic;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial membrane;Mitochondrial Proteins;Modeling;Mouse Protein;Mus;Neurons;new therapeutic target;Nuclear;overexpression;Oxygen Consumption;Pathogenesis;Pathway interactions;Pattern;PINK1 gene;protein expression;Proteomics;Reactive Oxygen Species;Role;sex;Sex Differences;Swelling;Testing;therapeutic target;Transgenic Organisms

PROJECT_TITLE: Relationships between APP and Mitochondria

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Schizophrenia involves dysconnection of separate brain areas, manifest in poor information transfer between cortical areas involved in complex processing of sensory information and construction of representations of the environment, important for successfully navigating the real world. Detection of novel sounds in the environment is critical for orienting and alerting, and is severely impaired in schizophrenia, but less so at disease onset. Examination of the distributed frontal lobe executive and temporal lobe auditory cortices and the interactions between bottom-up and top-down cortical processes shows great promise for understanding the basic molecular mechanisms of predictive coding, learning, memory, attention, and other key brain functions that are compromised by schizophrenia.

PI_NAMEs: COFFMAN, BRIAN A (contact)

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: Accounting;Area;Attention;Auditory;Auditory area;Automobile Driving;Biological Models;biological systems;Brain;brain abnormalities;causal model;Clinical;Code;Communication;Complex;Computer Models;Data;Detection;detection platform;deviant;Disease;Distributed Systems;Ear;Electroencephalography;Entropy;Environment;Etiology;Event;Failure;first episode psychosis;first episode schizophrenia;Frequencies;frontal lobe;Functional disorder;gamma-Aminobutyric Acid;Generations;Glutamates;gray matter;Head;healthcare burden;Healthcare Systems;Hearing Tests;Impairment;indexing;Individual;Inferior frontal gyrus;Learning;Left;Lesion;Lifelong disability;Location;Loudness;Magnetic Resonance Imaging;Major Mental Illness;Measures;Mediating;Memory;Modeling;Molecular;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;neural;neural circuit;neurophysiology;novel;Onset of illness;Participant;Pathology;Pattern;Phase;Play;Prefrontal Cortex;Process;Psychoses;Pyramidal Cells;Research;Resolution;Role;Scanning;Schizophrenia;sensor;Sensory;Social Functioning;Societies;sound;Source;Structure;Synapses;System;Taxes;Temporal Lobe;temporal measurement;Testing;Time;tool;Translating

PROJECT_TITLE: Systems-Level Dysconnectivity in First Episode Psychosis

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Services;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BAMAKO

ORG_COUNTRY: MALI

ORG_FIPS: ML

ORG_NAME: UNIV OF SCIENCES, TECH & TECH OF BAMAKO

PHR: Malaria and neglected tropical diseases (NTDs) remain significant causes of morbidity and mortality throughout Guinea and Mali, despite substantial progress achieved through implementation at large scale of prevention and control interventions. Improved in-country expertise in implementation research is critical to address major challenges that limit the translation of high-quality evidence into effective health programs. This Mali-Guinea research training program will strengthen the capacity of doctoral-level public health training programs and professional development to train the next generation of leadership in implementation research to ensure sustained, high performance of the local health systems, surveillance, monitoring and evaluation and timely scale up efforts of malaria and NTD control interventions.

PI_NAMEs: DELAMOU, ALEXANDRE ;DOUMBIA, SEYDOU  (contact);KAYENTAO, KASSOUM ;WINCH, PETER J

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: cohort;Collaborations;curriculum development;Development;Disease Outbreaks;disorder control;Doctor of Philosophy;doctoral student;drug resistance development;Educational Curriculum;Educational workshop;Ensure;Epidemiology;Evaluation;Evidence based intervention;Face;Faculty;Goals;graduate student;Grant;Guinea;Health Professional;Health Services Research;Health system;implementation research;Insecticide Resistance;Intervention;Leadership;Malaria;Mali;Mentorship;Monitor;Morbidity - disease rate;mortality;neglected tropical diseases;next generation;Pattern;Performance;Play;Prevention;Productivity;Program Sustainability;programs;Public Health;Public Health Education;public health research;Research;Research Personnel;Research Training;response;Role;scale up;Students;Teacher Professional Development;Training;Training Programs;Travel;World Health Organization

PROJECT_TITLE: Mali-Guinea Research Leadership Training Program for Sustainable control and elimination of Malaria and Neglected tropical diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(55)]


NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Obesity is a major risk factor for a number of chronic diseases, including type 2 diabetes, cardiovascular diseases, and cancer, yet the cause of this is not fully understood. Our preliminary data indicate that the inhibition of hypothalamic Rho-kinase expression leads to a significant increase in appetite, causing obesity. The goal of the study is to understand the new function of Rho-kinase in energy metabolism in the context of obesity, and the proposed experiments could lead to the identification of a potential target for new obesity-associated metabolic diseases.

PI_NAMEs: KIM, YOUNG-BUM  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Affect;Amygdaloid structure;Anorexia;Biochemical;Body Weight;Cardiovascular Diseases;Chronic Disease;Data;designer receptors exclusively activated by designer drugs;Desire for food;Eating;energy balance;Energy Metabolism;experimental study;Fatty acid glycerol esters;Fatty Liver;feeding;Genetic Engineering;Goals;GTP-Binding Proteins;Guanosine Triphosphate Phosphohydrolases;Homeostasis;Human;Hyperphagia;Hypothalamic structure;Impairment;inducible Cre;insight;insulin sensitivity;Knowledge;Link;Malignant Neoplasms;Mediating;Mediator;Melanocortin 4 Receptor;Metabolic;Metabolic Diseases;metabolic phenotype;Molecular;Morbid Obesity;mouse model;MSH receptor;Mus;Mutant Strains Mice;Mutation;neuron development;Neurons;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity development;obesity treatment;overexpression;Pakistan;Pathogenesis;Phosphotransferases;Physiological;Population;Recombinant adeno-associated virus (rAAV);Regulation;response;rho;Rho-associated kinase;Risk Factors;Signal Pathway;Signal Transduction;System;Techniques;Tissue Engineering;Transgenic Mice;Ubiquitin-Conjugating Enzymes;Ubiquitination;Variant;Weight Gain;α-Melanocyte stimulating hormone

PROJECT_TITLE: Rho-kinase signaling in energy balance

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Serious Mental Illness

ORG_CITY: BETHLEHEM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: LEHIGH UNIVERSITY

PHR: Project Narrative This proposal aims at developing treatment-predictive brain biomarkers jointly from fMRI and EEG for treatment selection in major depression. We will develop data-driven analytics to identify moderators and brain signatures predictive for antidepressant treatment response. The successful outcome of this project will promote the development of multimodal brain biomarkers that have been missed by existing approaches, leading to more effective interventions in depression, and laying the groundwork for a significant translational impact.

PI_NAMEs: ZHANG, YU  (contact)

PROJECT_TERMS: Adopted;analytical tool;anti-depressive agents;Attention;Biological Markers;biomarker identification;biomarker validation;biosignature;Brain;Brain region;Caring;Clinic;clinical care;clinical diagnosis;clinical effect;clinical heterogeneity;clinical outcome assessment;clinical practice;clinical predictors;Clinical Trials;clinically relevant;cohort;Communities;Conflict (Psychology);Coupled;Data;data archive;Data Set;data-driven model;depressed patient;Derivation procedure;design;Development;disability;Disease;Disease remission;effective intervention;Electroencephalography;Emotional;Exhibits;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Health;Heterogeneity;Individual;individual response;Machine Learning;machine learning model;Major Depressive Disorder;Medicine;Mental Depression;Mental disorders;Methods;Modality;Modeling;multimodal data;multimodal neuroimaging;multimodality;National Institute of Mental Health;neural circuit;neurobiological mechanism;Neurobiology;neuroimaging;novel;Outcome;outcome prediction;Patients;personalized medicine;Pharmaceutical Preparations;Phenotype;Placebo Effect;Placebos;Prediction of Response to Therapy;predictive marker;predictive modeling;predictive signature;Prevalence;Procedures;Protocols documentation;Psychiatry;Publishing;randomized placebo-controlled clinical trial;randomized, clinical trials;recruit;Regulation;Reproducibility;Research;Research Personnel;response;Rest;Sampling;Selection for Treatments;Selective Serotonin Reuptake Inhibitor;Sertraline;software development;Software Tools;Space Models;Symptoms;Techniques;Testing;tool;translational impact;treatment effect;Treatment outcome;treatment response;Validation;World Health Organization

PROJECT_TITLE: Establishing Multimodal Brain Biomarkers Using Data-driven Analyticsfor Treatment Selection in Depression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(91)S]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Although menthol cigarette smoking has been suggested to contribute to the disproportionate burden of lung cancer among African Americans, epidemiological evidence on this issue remains scarce, especially for its biological mechanism underlying lung carcinogenesis. The overarching goal of this proposed study is to identify menthol cigarette smoking-related blood metabolites and evaluate their associations with lung cancer risk by leveraging pre-diagnostic blood samples, rich epidemiologic data, and recently generated metabolomics data in a prospective cohort of primarily low-income African Americans. Findings from this proposed study will enhance our understanding of the biological role/harms of menthol cigarette smoking in lung cancer etiology, especially among African American men who suffer the highest burden of lung cancer.

PI_NAMEs: CAI, QIUYIN ;YOON, HYUNG-SUK  (contact)

PROGRAM_OFFICER_NAME: DELLAVALLE, CURT TAVIS

PROJECT_TERMS: Address;Adenocarcinoma;Affect;African American;African American population;Age;American;Biological;Biological Assay;Blood;Blood specimen;Cancer Etiology;cancer health disparity;cancer risk;Carcinogens;Cessation of life;Characteristics;Cigarette;cigarette smoking;Cohort Studies;Communities;cost efficient;Cotinine;Data;Diagnosis;Diagnostic;Disparity;Disparity population;Drug Metabolic Detoxication;Elasticity;epidemiologic data;Epidemiology;epidemiology study;ethnic disparity;Ethnic Origin;Ethnic Population;Etiology;European;Funding;Future;Goals;hazard;innovation;insight;Interdisciplinary Study;Investigation;Knowledge;Linear Models;Link;Liver Microsomes;Logistic Regressions;Low income;lung cancer prevention;lung carcinogenesis;male;Malignant neoplasm of lung;Malignant Neoplasms;men;Menthol;Metabolic;metabolic profile;Metabolism;metabolomics;Modification;Molecular;Movement;Nested Case-Control Study;Nicotine;nicotine exposure;novel;Pathogenicity;Pathway Analysis;Pathway interactions;Plasma;population based;Population Study;preventable death;Prospective cohort;Prospective Studies;Public Health;Questionnaires;Race;racial disparity;racial population;Random Allocation;Reporting;Research;Risk;Risk Factors;Role;sex;Smoker;Smoking;smoking-related disease;Socioeconomic Status;Standardization;Statistical Models;Tobacco;Validation;Variant;Woman

PROJECT_TITLE: Menthol cigarette smoking-related blood metabolites and lung cancer risk


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Problems in scientific practice have generated widespread concern about the reliability of findings in behavioral and social science research, including work related to aging, presenting risks to the effectiveness of policy and practice, as well as public trust in science. Led by the Berkeley Initiative for Transparency in the Social Sciences (BITSS), five annual Research Transparency and Reproducibility Training (RT2) short courses will provide critical training to equip behavioral and social scientists to conduct credible research, and strengthen a growing community of researchers committed to changing norms in their own networks. Access to these short courses and the open science community will empower early career researchers to conduct credible research on aging, extend their teaching to others, and help level the playing field in terms of who participates in ongoing transformations in the scientific ecosystem.

PI_NAMEs: MIGUEL, EDWARD ANDREW (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Academia;Adopted;Adoption;Aging;Awareness;Behavior;Behavioral;behavioral and social science;career;catalyst;Code;Collaborations;Communication;Communities;curriculum enhancement;Data;design;Ecosystem;Educational Curriculum;Educational process of instructing;Educational workshop;Effectiveness;effectiveness evaluation;empowerment;Equity;Event;experimental study;Exposure to;Feedback;Funding;graduate student;improved;Incentives;interest;Interview;Investments;Lead;Learning;learning materials;member;Methodology;open data;Participant;Patient Self-Report;pedagogical content;peer;Play;Policies;Policy Maker;Postdoctoral Fellow;Process;public trust;Publishing;Qualitative Methods;Random Allocation;Reporting;Reproducibility;Research;Research Methodology;Research Personnel;Resource Sharing;Risk;Science;Scientist;social;social science research;Social Sciences;success;Surveys;Technical Expertise;tool;Training;Transferable Skills;Work


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Depression;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative/Public Health Relevance:  Early life stress (ELS) is a significant risk factor for the development of psychopathology from childhood to  young adulthood; in this project we will augment our existing rich longitudinal dataset by conducting an  additional assessment of our participants at age 20 to examine the effects of ELS on trajectories of  neurodevelopment and clinical outcomes from childhood to young adulthood, as well as the persistence of  COVID-19 pandemic-related difficulties in mental health, stress, and brain metrics. We will also extend and  replicate our findings in a larger, younger, non-Western sample of youth, in whom we will also examine the  effects of the COVID-19 pandemic on young people’s health. Findings from this project will inform efforts to  generate personalized targets in order to tailor prevention and treatment programs for adolescents who are at  high risk for the onset of depression, for other forms of psychopathology, and for engaging in suicidal  behaviors.

PI_NAMEs: GOTLIB, IAN H (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: 13 year old;9 year old;Address;Adolescence;Adolescent;Adult;Adverse effects;Affect;Age;Air Pollutants;Award;Behavior assessment;Behavioral;Biological;Biological Aging;Blood;boys;Brain;Cause of Death;Child;Childhood;Clinical;Cognitive;cohort;Cohort Studies;Collaborations;Complement;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Analytics;Data Set;deprivation;Development;Diagnosis;Dimensions;Disease;early life adversity;early life stress;economic disparity;Endocrine;Environmental Exposure;Environmental Pollutants;Equation;experience;Exposure to;Family;girls;Grant;Health;health disparity populations;high risk;Immunologics;Interview;large datasets;Life;Life Cycle Stages;longitudinal dataset;Machine Learning;Measurement;Measures;Mental Depression;Mental Health;Modeling;neural;neurodevelopment;neuroimaging;Not Hispanic or Latino;Outcome;pandemic disease;Paper;Parents;Participant;Persons;Physiology;Predictive Factor;prenatal;Prevention;Prevention program;promote resilience;Prospective Studies;psychobiologic;Psychopathology;psychosocial;public health relevance;Publishing;Quarantine;racial population;recruit;resilience;resilience factor;Rewards;Risk;Risk Factors;risk prediction;Saliva;Sampling;Series;Severities;Singapore;southeast Asian;Specimen;Stress;stress reactivity;Stressful Event;suicidal behavior;Suicide attempt;Symptoms;Techniques;Testing;treatment program;United States National Institutes of Health;Work;young adult;Youth

PROJECT_TITLE: Psychobiological Mechanisms Underlying the Association Between Early Life Stress and Depression Across Adolescence

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hematology;Lung;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Sleep Research;Social Determinants of Health

ORG_CITY: SAN ANTONIO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Narrative Although a large proportion of individuals living in rural Appalachia and the Mississippi Delta (AMD) experience strikingly high rates of heart and lung disease (hot spots), some other communities in the same region seem to be relatively spared (cold spots). To study this regional variation in disease risk and the potential basis of resilience of `cold spots', we will recruit and study 4000 young-to-middle aged men and women from different race/ethnicity groups living in six high risk and four lower risk poor rural counties in four Southern states. We will reach these communities using a mobile van, and measure levels of both protective and harmful influences in the people and their neighborhoods, hoping to understand what causes the high burden of heart and lung disease in these rural Southern regions and how to improve and prevent it.

PI_NAMEs: JUDD, SUZANNE E;RAMACHANDRAN, VASAN S (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Acceleration;adjudication;Affect;Age;Alabama;allostatic load;Ankle;Appalachian Region;Behavioral;biobank;Biological Assay;Biological Process;Black Populations;Blood;Buffers;burden of illness;Cellular Phone;Clinic;Clinical;cohort;Cohort Studies;Communities;Community Health;Complex;coronary artery calcium;County;Data;data harmonization;data repository;Death Rate;Development;Diabetes Mellitus;digital technology;Disease;disorder risk;Disparity population;early onset;Economic Factors;Economics;Environment;Environmental Risk Factor;Epidemic;Ethnic Origin;Ethnic Population;Etiology;Event;experience;Frequencies;Future;Generations;Genetic Predisposition to Disease;Genetic Risk;Glucose;Health;health disparity populations;Health education;Health Personnel;Health Technology;Heart;Heart Diseases;Heart Rate;Hematological Disease;high risk;Hispanic;Home;Hot Spot;Hour;Hypertension;Imaging technology;implementation science;improved;Incidence;indexing;Individual;Individual Differences;innovation;Kentucky;Kidney Diseases;Knowledge;Learning;Life Cycle Stages;Life Style;lifestyle factors;Longitudinal cohort study;Longitudinal Studies;Louisiana;Lung;Lung Diseases;male;Malignant Neoplasms;Measures;Mediation;Medical History;Medical Records;men;mHealth;middle age;Minority Status;Mississippi;mobile computing;Modernization;Modification;Monitor;Morbidity - disease rate;mortality;multi-ethnic;Neighborhoods;novel;Obesity;Oral;Participant;Patient Recruitments;Patient Self-Report;Pattern;Persons;Physiologic pulse;Physiological;polygenic risk score;Population Sizes;Postural adjustments;Poverty;premature;Prevalence;prevent;Prognosis;progression risk;prospective;Psychosocial Factor;psychosocial wellbeing;Public Health;Publishing;pulmonary function;Race;racial population;recruit;residence;resilience;resilience factor;response;Risk;Risk Factors;Rural;Rural Appalachia;rural area;Rural Community;rural counties;Rural Health;rural setting;rurality;Sampling;Scientist;sex;Sleep;Sleep Disorders;social;social factors;Spirometry;Spottings;syndemic;Testing;Time;tool;trait;Translating;United States;urban area;Variant;Walking;wearable device;Woman;X-Ray Computed Tomography

PROJECT_TITLE: RURAL: Risk Underlying Rural Areas Longitudinal Cohort Study


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE TBI is associated with significant morbidity, including cognitive impairment and dementia, but the mechanisms linking TBI to dementia remain poorly understood. The central hypothesis of this proposal is that TBI is associated with cognitive decline and dementia risk in part via vascular pathways which accelerate neurodegeneration for years post-TBI. The overall scientific objective of this proposal is to use blood-based and neuroimaging biomarkers of vascular injury and dysfunction to investigate mechanisms linking TBI and neurocognitive outcomes and to identify time-periods during which future interventions may be effective at preventing TBI-related dementia.

PI_NAMEs: SCHNEIDER, ANDREA LAUREN CHRISTMAN (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acceleration;Acute;acute care;Address;Alzheimer's disease related dementia;Atherosclerosis Risk in Communities;Biological Assay;Biological Markers;Blood;Blood brain barrier dysfunction;Blood Vessels;blood-based biomarker;blood-brain barrier function;career;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Trauma;Chronic;Clinical;clinical center;clinical epidemiology;clinical implementation;Clinical Research;Cognitive;cohort;Cohort Studies;Collaborations;Communities;Data;Data Collection;Dementia;dementia risk;design;Disease;effective therapy;Endothelium;Environment;Epidemiology;epidemiology study;follow-up;Freezing;Functional disorder;Funding;Future;Goals;Health;high risk;Impaired cognition;improved;Individual;Injury;Institution;Intervention;Knowledge;Link;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Methods;modifiable risk;Morbidity - disease rate;mortality;Multicenter Studies;multimodality;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Neurocognitive;neuroimaging marker;neuroinflammation;novel;Outcome;Pathway interactions;Patient Recruitments;Pennsylvania;Persons;Population Scientist Supplement (R25);prevent;Prevention;Process;programs;prospective;Prospective, cohort study;protein aggregation;Recommendation;recruit;Reporting;Research;Role;Sampling;skills;Source;Specimen;symposium;TBI Patients;TBI treatment;therapeutic target;Time;Training;trauma centers;Traumatic Brain Injury;Traumatic brain injury related dementia;United States;Universities;validation studies;Vascular Diseases;vascular injury;Work

PROJECT_TITLE: Establishing Mechanisms Between Traumatic Brain Injury and Dementia Using Epidemiology, Clinical Studies, Blood-Based Biomarkers, and Neuroimaging Biomarkers


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Program Director/Principal Investigator: Peterson, Craig, Lewis NARRATIVE STATEMENT Chromosome structure plays a central role in regulating the the expression of genes, the repair of DNA, and the faithful copying of DNA during cell division. The studies described here will investigate the role of key enzymes that remodel chromosome structure and regulate these events. In mammals, these factors are essential for development and stem cell identity, and their inactivation can lead to tumorogenesis and other diseases. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: PETERSON, CRAIG L (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Aneuploidy;Area;Biological Assay;Buffers;Cell division;Centromere;Chromatin;chromatin remodeling;Chromosome Structures;Chromosomes;Code;Collaborations;Complex;Cryoelectron Microscopy;Deposition;Development;dimer;Disease;DNA;DNA biosynthesis;DNA Repair;DNA replication fork;Enzymes;Equilibrium;Event;Experimental Genetics;Fluorescence;forkhead protein;G2 Phase;Gene Expression;Genes;genetic approach;Genetic Transcription;Genome Stability;Genomics;Histones;Homologous Gene;in vivo;Link;Maintenance;Malignant Neoplasms;Mammalian Cell;Mammals;Mass Spectrum Analysis;Methods;Molecular Genetics;novel;Nuclear;Nucleosomes;Play;prevent;Principal Investigator;Process;programs;promoter;Reaction;Regulation;Replication Origin;Repression;Research;RNA Polymerase II;Role;S phase;single molecule;stem cell function;stem cells;Structure;Transcript;Transcriptional Regulation;Untranslated RNA;Variant;virtual;Work;Yeasts

PROJECT_TITLE: Regulation of chromatin dynamics

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cervical Cancer;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_NAME: KOVINA THERAPEUTICS INC.

ORG_STATE: IN

PHR: Human papillomaviruses (HPV) encode proteins that can cause abnormal growth of infected cells. Kovina  Therapeutics has licensed and is further developing drug-like compounds that block the function of a specific  viral protein and inhibit growth of HPV cancer cells. Using sophisticated and powerful multidisciplinary  approaches, our team will characterize these inhibitors in order to begin human clinical trials.

PI_NAMEs: RIETZ, ANNE  (contact)

PROGRAM_OFFICER_NAME: POND, MONIQUE ADRIANNE

PROJECT_TERMS: Academia;adduct;Affinity;Algorithms;Anti-viral Agents;Binding;Biochemical;Biological Assay;Biotechnology;Businesses;cancer cell;Cancer cell line;Canis familiaris;career;Cell Culture Techniques;cell growth;Cell Proliferation;Cell Survival;Cells;cellular targeting;Cervical;Chemistry;chronic infection;Clinical;Clinical Trials;Complex;Coupled;covalent bond;Cysteine;Cytochrome P450;Data;design;Development;dosage;Dose;drug candidate;Drug Design;drug development;Drug Industry;Drug Kinetics;drug-like compound;Epithelium;Evaluation;Exhibits;experience;experimental study;Fluorescence Polarization;Funding;Good Manufacturing Process;Growth;high risk;HPV positive;HPV-High Risk;Human;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immunocompromised Host;Immunodeficient Mouse;in silico;In Vitro;in vitro activity;in vivo;Infection;inhibitor;interdisciplinary approach;Interferometry;intravenous administration;Investigation;iterative design;Lead;lead candidate;lead optimization;Licensing;Liver Microsomes;Malignant - descriptor;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant neoplasm of penis;Malignant neoplasm of vulva;Malignant Neoplasms;malignant oropharynx neoplasm;Malignant Vaginal Neoplasm;manufacture;Mass Spectrum Analysis;Maximum Tolerated Dose;Mediating;Medical;Mentors;Metabolism;meter;Microsomes;Molecular;multicatalytic endopeptidase complex;Mus;Neoplastic Cell Transformation;novel therapeutics;Oral;Oropharyngeal;Outcome;Pathology;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetic model;pharmacologic;Pharmacotherapy;Phase;phase 1 study;Plasma;Positioning Attribute;premalignant;prevent;Prevention;Property;Proteins;Rattus;Roentgen Rays;Route;Safety;scaffold;Schools;screening;Series;Small Business Innovation Research Grant;Small Business Technology Transfer Research;small molecule;small molecule libraries;Structure;subcutaneous;Surface;Testing;Therapeutic;time use;Toxic effect;Toxicology;TP53 gene;tumor;Tumor Cell Line;tumor growth;Tumor Suppressor Proteins;tumor xenograft;UBE3A gene;ubiquitin ligase;Ubiquitination;Validation;Viral Genome;Viral Proteins;Virus Diseases;Virus Replication;Woman;Xenograft Model

PROJECT_TITLE: From Academia to Business: Development of Novel Therapeutics Against HPV-Associated Cancer


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE: Interrogating the cholinergic basis of opioid use disorder Here, we propose to develop, characterize, and deploy a comprehensive toolset focused on opioid neuropharmacology. We will test the hypothesis that μORs on cholinergic interneurons mediate harmful effects of opioids, independent of therapeutic analgesic effects. The proposed technologies will offer the unprecedented opportunity to establish causal behavioral roles of opioid neuropharmaceuticals mediated by defined cell types.

PI_NAMEs: TADROSS, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Absence of pain sensation;Acute;Address;Adjuvant Therapy;Adoption;Affect;Analgesics;Animals;anxiety treatment;Axon;Behavior;Behavioral;brain volume;Buprenorphine;Catalogs;cell type;Cells;Chemicals;cholinergic;Cholinergic Agents;Clinical;clinical efficacy;Clinical Trials;clinically relevant;cognitive enhancement;Communities;design;Development;Dissociation;Dopamine;Dose;double-blind placebo controlled trial;drug action;Experimental Designs;experimental study;Foundations;Galantamine;Genetic;In Vitro;in vivo;Incidence;Infusion procedures;insight;Interneurons;Knowledge;Ligands;Literature;Locales;Maps;Mediating;Mental Depression;Methadone;Methods;Modeling;mu opioid receptors;Mutation;Naloxone;Neuropharmacology;Neurosciences;novel;Nucleus Accumbens;Opiate Addiction;Opioid;Opioid agonist;Opioid Antagonist;Opioid Receptor;opioid use;opioid use disorder;overexpression;Oxymorphone;Pain management;Pharmaceutical Preparations;Pharmacology;Psychoses;Publishing;Reagent;receptor;Relapse;Risk;risk minimization;Rodent Model;Role;Science;side effect;Signal Transduction;Specificity;Substance Use Disorder;System;Technology;Testing;theories;Therapeutic;Time;tool;Validation;Work


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE The use of electronic nicotine delivery systems (ENDS or e-cigarettes) has reached epidemic levels among young people in the US. ENDS use among young people is driven in part by misperceptions of their safety. Health communication of ENDS-related risks is a priority, and this proposal focuses on developing and testing health warnings for young ENDS users.

PI_NAMEs: ASFAR, TAGHRID ;MAZIAK, WASIM  (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: 21 year old;addiction;Affect;Attention;Behavior;behavior influence;Brain;Chemicals;Cigarette;cigarette smoking;Clinical;Communication;comparison control;Consensus;Coupled;Cross-Over Studies;Delphi Study;Dependence;design;Development;Devices;Electronic cigarette;Electronic Nicotine Delivery Systems;Emerging Tobacco Products;Epidemic;Event;evidence base;experience;experimental study;Exposure to;Feedback;Focus Groups;follow-up;Health;health application;health communication;health warning;High School Student;Industry;Intention;Knowledge;laboratory experiment;Long-Term Effects;Marketing;Methods;Modality;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Nicotine;Nicotine Dependence;nicotine exposure;Outcome;Participant;Perception;Performance;Persons;pilot test;Plasma;Poison;Policy Maker;psychologic;public health relevance;Randomized;Reaction;recruit;Regulation;Reporting;Review Literature;Risk;Safety;satisfaction;sex;Smoker;smoking initiation;Surveys;Target Populations;Testing;Text;Time;Tobacco;tobacco control;Tobacco use;toxicant;United States;uptake;warning label;Work;young adult;Youth

PROJECT_TITLE: Developing and testing health warning labels on the ENDS device


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: GLEN ALLEN

ORG_NAME: ARCHE VR LLC

PHR: Project Narrative Conduct disorder (CD) is one of the most prevalent and impairing psychiatric disorders among youth, yet, treatment options are limited and those treatments that do exist largely focus on behavior management rather than targeting the mechanisms that contribute to the development and stability of CD. This project aims to evaluate a new and innovative treatment for CD, called Impact VR, a Virtual Reality emotion recognition and regulation training program, specifically designed to target the developmental mechanisms of CD. Our goal is to assess its acceptability among youth with CD, and its feasibility for deployment across settings (e.g., schools, hospitals), as well as conduct a randomized control trial to assess its preliminary effectiveness for reducing CD and callous-unemotional traits.

PI_NAMEs: THOMSON, NICHOLAS DAVID;VRANA, SCOTT R. (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Address;Adolescence;Adult;Affect;Aggressive behavior;antisocial behavior;Behavior;Behavioral;Businesses;callous unemotional trait;Childhood;Chronic;Clinic;Cognitive;Conduct Disorder;conduct problem;cost;criminal behavior;design;Development;Diagnosis;Diagnostic;Disease;Educational process of instructing;Effectiveness;emotion regulation;Emotions;Empathy;Ensure;evidence base;Evidence based treatment;Face;Floor;follow-up;Goals;Guilt;Health;Home;Hospitals;Impairment;Improve Access;improved;individualized medicine;innovation;Instruction;Intervention;Legal;Link;Marketing;Mediator;Mental disorders;Mental Health;Modification;Motivation;National Institute of Mental Health;Occupational Health;Outcome;Outcome Study;Parents;Performance;Phase;phase 1 study;physical conditioning;Play;Prevention strategy;Process;Provider;psychoeducation;psychoeducational intervention;Psychopathology;psychosocial;Randomized, Controlled Trials;Regulation;Reporting;Research Domain Criteria;Resistance;Resources;Rights;Risk;Role;rural area;school health;Schools;showing emotion;Small Business Technology Transfer Research;social;Standardization;Symptoms;System;Technology;Testing;Time;Training;Training Programs;treatment strategy;urban area;usability;Virginia;virtual reality;virtual reality game;virtual reality intervention;visual tracking;Youth

PROJECT_TITLE: Impact VR: An Emotion Recognition and Regulation Training Program for Youth with Conduct Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-C(10)B]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Mental Health;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Public Health Relevance Alcohol use and sexual assault are significant, co-occurring problems on college campuses. Women with a history of sexual victimization are at increased risk for revictimization when they drink to cope with sex-related distress; a common aftereffect of trauma. This treatment development study will develop and pilot an integrated intervention that targets alcohol use, sex-related distress, and sexual revictimization among college women with a history of severe sexual victimization who report past month heavy drinking, sexual activity, and sexual distress; a particularly high-risk group.

PI_NAMEs: ORCHOWSKI, LINDSAY MARIE (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Alcohol consumption;alcohol expectancy;alcohol intervention;alcohol misuse;alcohol misuse prevention;alcohol related consequences;alcohol use disorder;Arousal;assault;Attention;Classification;Clinical;Clinical Trials;Cognitive Therapy;college;Competence;Control Groups;coping;Data;Development;Disease;Distress;Dose;drinking;Education;Empirical Research;empowerment;Event;evidence base;experience;Feedback;Female;Focus Groups;follow-up;Forcible intercourse;Foundations;Frequencies;Functional disorder;Genitalia;Goals;Health;Health Promotion;Heavy Drinking;high risk population;improved;inclusion criteria;informant;information gathering;innovation;Intervention;intervention delivery;Interview;Manuals;Mediator;Methods;Mindfulness Training;model development;Modeling;Modification;motivational enhancement therapy;National Institute on Alcohol Abuse and Alcoholism;Outcome;Pain;Participant;Patient Self-Report;perpetrators;Pharmaceutical Preparations;Phase;Pilot Projects;pilot trial;Population;prevent;Prevention approach;Prevention strategy;Procedures;programs;Protocols documentation;Public Health;public health relevance;Randomized;Readiness;Recording of previous events;recruit;reduced alcohol use;Reporting;Research;Research Design;Research Infrastructure;Resistance;retention rate;revictimization;Risk;Risk Factors;Risk Reduction;Role;Sampling;Seasons;Severities;sex;Sex Behavior;sexual assault;Sexual Dysfunction;Sexual Health;sexual risk reduction;sexual trauma;sexual victimization;sexually active;sound;Strategic Planning;Structure;Substance Addiction;Survivors;Techniques;Testing;theories;therapy development;Training;Trauma;trauma symptom;university student;Victimization;Woman;Women's Group;Women's Health

PROJECT_TITLE: Reducing Alcohol Use and Sexual Dysfunction in Survivors of Sexual Trauma

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Endocrine Disruptors;Estrogen;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Elucidating how genetic and environmental factors interact has potential to improve our currently limited understanding of the etiology, phenotypic heterogeneity, and rising prevalence of Autism Spectrum Disorder. The proposed research applies novel analytic methodologies to understand the interrelationships between endocrine-disrupting chemicals, genetics, and immune dysregulation, and their role in ASD development. This knowledge will ultimately lead to better identification of high-risk mothers and children and guide development of strategies to protect vulnerable subgroups.

PI_NAMEs: AMES, JENNIFER LISA (contact)

PROGRAM_OFFICER_NAME: LAWLER, CINDY P

PROJECT_TERMS: Address;Affect;American;autism biomarker;autism spectrum disorder;autistic children;Award;Behavioral;Biological;Biological Markers;Candidate Disease Gene;career;Case/Control Studies;chemical association;Child;Chronic;cohort;Cohort Studies;Collaborations;Complex;Complex Mixtures;Data;Development;developmental disease;Dioxins;Endocrine;Endocrine Disruptors;Environment;environmental chemical;Environmental Risk Factor;Epidemiology;epidemiology study;Etiology;Exposure to;fetal;Financial cost;gene environment interaction;Genes;Genetic;genetic risk factor;genetic variant;Genetic Variation;genome wide association study;genome-wide;genome-wide analysis;Genomics;Genotype;Goals;Heterogeneity;high risk;Immune;immune function;Immune system;Immune Targeting;Immunologic Markers;Immunologics;Immunology;improved;Individual;Infant;Inflammation;inflammatory marker;insight;Intervention;Investigation;Joints;Knowledge;Life;Link;Mediating;Mediation;Medical;Mentors;Mentorship;Metabolic;Methodology;Methods;Modeling;modifiable risk;Mothers;multidisciplinary;Neonatal;neurotoxic;neurotoxicity;novel;Pathway interactions;Perinatal;pharmacologic;Phase;Phenotype;Physiological;Physiology;Placenta;placental transfer;pollutant;polygenic risk score;population based;Positioning Attribute;Pregnancy;pregnancy circulation;Pregnant Women;prenatal;prenatal exposure;Prevalence;programs;Public Health;public health relevance;Recording of previous events;Research;Research Activity;Risk;Risk Factors;Role;screening;Sensory;skills;social;Subgroup;targeted treatment;Testing;therapeutic target;tool;Training;Training Activity;United States National Institutes of Health;Variant;Work;Xenobiotic Metabolism

PROJECT_TITLE: Interactions of Environmental Chemical Mixtures, Genetics, and Immune Pathways in Autism Spectrum Disorder