NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Dengue virus has a profound impact on human health with 390 million infections and 25,000 deaths annually worldwide. In this study, we will develop and characterize a vaccine against dengue virus utilizing the mRNA platform. With this approach, mRNA encoding for viral proteins is encapsidated in a lipid nanoparticle which will allow us to rapidly generate and screen for vaccines which are efficacious and safe that will be further evaluated as candidate human vaccines.

PI_NAMEs: RICHNER, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Adoptive Transfer;Animal Model;Animals;Antibodies;Antibody Repertoire;Antibody-Dependent Enhancement;Antigens;B-Lymphocytes;Bite;Blood Pressure;cell mediated immune response;Cells;Cessation of life;Clinical;Clinical Trials;combat;Contracts;cross reactivity;Culicidae;Data;Dengue;Dengue Vaccine;Dengue Virus;Dengvaxia;design;Disease;Engineering;env Gene Products;Epitopes;Evaluation;experimental study;Extravasation;Fever;Flavivirus;Future;Glycoproteins;Health;Hemorrhage;hospitalization rates;Human;Immune;Immune response;Immunity;Immunocompetent;immunogenicity;immunosuppressed;in vivo;Individual;Infection;Lead;Licensing;lipid nanoparticle;Maps;Measures;Membrane;Membrane Proteins;Messenger RNA;Modeling;Monitor;mouse model;mRNA delivery;mRNA lipid nano particle vaccine;Mus;Mutate;nonhuman primate;novel;novel vaccines;Nucleosides;Organ failure;particle;pathogen;Persons;Plasma;polyclonal antibody;Population;pre-clinical;Predisposition;Pregnant Women;Primary Infection;Probability;protective efficacy;Protein Biosynthesis;Refractory;response;Risk;RNA vaccine;secondary infection;Serotyping;Serum;severe dengue;Severity of illness;Shock;Structure;Surface;Symptoms;T-Lymphocyte;T-Lymphocyte Epitopes;Techniques;Technology;Therapeutic;transmission process;Vaccinated;Vaccination;vaccine candidate;vaccine efficacy;vaccine evaluation;vaccine formulation;vaccine immunogenicity;vaccine safety;Vaccinee;Vaccines;Viral;Viral Proteins;Virion;Virus Diseases;Zika Virus

PROJECT_TITLE: Dengue virus mRNA lipid nanoparticle vaccine

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Household air pollution resulting from cooking with solid fuels (wood, charcoal, animal dung, coal), the primary household energy source for nearly 3 billion people, is responsible for an estimated 2.3 million premature deaths and additional morbidity burden each year, primarily in low- and middle income countries, and are also major sources of climate warming gases. The proposed work will leverage the ongoing Household Air Pollution Intervention Network (HAPIN) trial by evaluating whether a liquefied petroleum gas (LPG) stove and fuel intervention during the first 500 days of life (pregnancy and early childhood) and the substantial differences in personal exposure (fine particulate matter and black carbon) and preliminary indications of improvements in health outcomes, impact child development beyond the child’s first year of life. The proposed work will impact health, environmental, climate and energy policies by providing rigorous and widely generalizable insight to questions regarding the impact of this intervention and a range of exposure levels on child neurologic and physical development through the age of 5, indicators of longer-term educational achievement, economic productivity and health.

PI_NAMEs: CLASEN, THOMAS F (contact);PEEL, JENNIFER L

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Address;Adherence;Adopted;Adult;Age;Age Months;Air Pollution;Animals;arm;Assessment tool;Behavior;Biomass;biomass fuel;Birth;Carbon;Carbon Black;Carbon Dioxide;Cessation of life;Charcoal;Child;Child Development;Child Health;Climate;climate change;Coal;cohort;Control Groups;cooking;Cooking Practices;Country;critical developmental period;critical period;Data;Data Collection;Data Set;design;Development;disorder risk;early childhood;early life exposure;Economics;Educational Status;Energy-Generating Resources;Enrollment;Environmental Exposure;Evaluation;experience;Exposure to;fine particles;follow-up;Gases;Generations;Growth;Growth and Development function;Guatemala;Health;Health Benefit;Heterogeneity;Hour;Household;Household Air Pollution;improved;India;Infrastructure;insight;Intention;Intervention;intervention effect;Investments;Length;Life;Link;Literature;low and middle-income countries;Malawi;Measurement;Measures;Monitor;Morbidity - disease rate;Mothers;Neurologic;Outcome;Participant;Persons;Peru;Petroleum;Policies;policy implication;Policy Maker;Positioning Attribute;post intervention;Pregnancy;Pregnant Women;premature;Productivity;Randomized;Research;Resource-limited setting;response;Rwanda;Science;Site;solid fuel;Source;success;successful intervention;treatment arm;United States National Institutes of Health;Weight;Wood material;Work

PROJECT_TITLE: Assessing the 5-Year Effects of a 500-day Liquefied Petroleum Gas Cooking Intervention:  Continued Follow up of Participants from the Household Air Pollution Intervention Network (HAPIN) trial

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Neurodegenerative

ORG_DEPT: GENETICS

PHR: Project Narrative This proposal will develop novel Bayesian statistical tools for integrating multi-omics (i.e., epigenetic, transcriptomic, proteomic, and metabolomic) data with GWAS data to elucidate the genomic etiology of complex phenotypes. We will validate our methods by applying them to unique multi-omics and GWAS data profiled from older adults with well-characterized phenotypic data, along with relevant public summary-level data, for studying Alzheimer's disease dementia. These novel methods have the potential to increase the information obtained from integrative multi-omics studies to improve our understanding about the genomic etiology of complex phenotypes, thus providing novel gene targets for further drug discovery and improve identification of at-risk individuals.

PI_NAMEs: YANG, JINGJING  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Aging;Algorithms;Alzheimer's Disease;Bayesian Analysis;Bayesian Method;Biological;Complex;Computer software;Data;Dementia;drug discovery;Enhancers;Epigenetic Process;Etiology;flexibility;Gene Targeting;genetic architecture;Genetic Transcription;genome wide association study;genome-wide;Genomics;improved;Individual;interest;Knowledge;Linkage Disequilibrium;Maps;Memory;metabolomics;Methods;Modeling;Molecular;Multiomic Data;multiple omics;novel;older adult;Phenotype;phenotypic data;Proteomics;Quantitative Trait Loci;religious order study;Risk;risk variant;Sample Size;tool;transcriptomics;Uncertainty;Validation;Variant;Work

PROJECT_TITLE: Novel Bayesian statistical tools for integrating multi-omics data to help elucidate the genomic etiology of complex phenotypes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cardiovascular;Clinical Research;Physical Activity;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE  Long term endurance athletes are commonly found to have enlargement of the aorta, the largest artery in the body, potentially a highly dangerous condition, leading to speculation that years of exercise training may be a driver of this arterial enlargement. We plan to study whether exercise training may contribute to aortic enlargement through evaluation of a large group of endurance athletes whom we initially enrolled 5 years ago, and our study will include an assessment for interval aortic growth along with a detailed physiologic survey and analysis of potential molecular mechanisms that may contribute to this condition. In doing so, we aim to understand how and why this condition develops, what risks it may confer, and what lessons it may offer for the role of exercise in the treatment of all patients with aortic disease.

PI_NAMEs: CHURCHILL, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acute;Age;aging population;anatomic imaging;Aorta;Aortic Diseases;Area;Arteries;ascending aorta;Biochemical;Biological Markers;Biology;Blood flow;Blood Pressure;Blood Vessels;Body Size;Caliber;Cardiac;Cardiopulmonary;Cardiovascular system;career;career development;Chronic;circulating microRNA;Clinical Investigator;clinical outcome assessment;clinical practice;cohort;comparative;comparison group;Dangerousness;Data;Development Plans;Dilatation - action;Dose;Echocardiography;endurance exercise;Enrollment;Environment;Equilibrium;Evaluation;Exercise;Exercise Physiology;Exercise Test;exercise training;Exertion;experience;follow-up;Functional disorder;Future;General Hospitals;General Population;Genetic;Goals;Grant;Growth;Health;heart imaging;high risk population;Human;Hypertension;Image;indexing;Individual;insight;Isometric Exercise;Isotonic Exercise;male;Maps;Massachusetts;Mediator;Mentored Patient-Oriented Research Career Development Award;Mentorship;MicroRNAs;Mission;Modeling;Molecular;multidisciplinary;Myocardial;Natural History;next generation sequencing;novel;Organ;Pathologic;Pathology;Patients;Pattern;Performance;Phenotype;Physical activity;Physiological;Physiology;Plasma;Play;Population;Positioning Attribute;Prevalence;primary outcome;Process;programs;prospective;Publications;Regulation;Research;Research Methodology;Research Proposals;response;Rest;Risk;Risk Factors;Role;Sampling;Science;Scientist;sedentary;sex;Sports;Strenuous Exercise;Structure;Surveys;Syndrome;Techniques;Testing;Time;Tissues;Training;transcriptome sequencing;Translating;Translational Research;translational scientist;translational study;Uncertainty;Validation;Veterans;Work;X-Ray Computed Tomography

PROJECT_TITLE: Aortic Dilatation in Endurance Athletes: A Physiologic and Mechanistic Study

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Childhood Obesity;Clinical Research;Neurosciences;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Individuals with obesity versus without obesity show evidence of weaker satiation signaling, however, research has yet to determine the direction of influence between obesity and weaker satiation signaling. The proposed study will test whether healthy weight youth at high-risk for obesity show weaker neural satiation signaling than low-risk youth (Aim 1), test whether youth who show weaker neural satiation signaling will show elevated future weight gain (Aim 2), and the impact of percent body fat gain at 3-year follow-up on the possible reduction in satiation signaling (Aim 3). This study can determine whether weaker satiation signaling is an initial vulnerability factor for weight gain, is the result of habitual overeating, or is dynamically related in a feed- forward fashion; an improved understanding of risk processes for obesity should guild the design of more effective prevention programs and treatments.

PI_NAMEs: BURGER, KYLE S. (contact);STICE, ERIC M

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Adipose tissue;Adolescence;Adolescent;adult obesity;Affect;aged;Appetite Depressants;Attenuated;Behavioral;Body Composition;Body fat;Body measure procedure;Body Weight decreased;Brain;Brain region;Calories;Cerebrovascular Disorders;Cognitive;connectome;Consumption;Corpus striatum structure;Cues;Data;Dementia;design;Disease;Eating;Energy Intake;excessive weight gain;Fasting;Fingerprint;follow-up;Food;Functional Magnetic Resonance Imaging;Future;glucagon-like peptide 1;Habits;healthy weight;high risk;Hormones;Hyperphagia;Impaired cognition;improved;indexing;Individual;Individual Differences;Knowledge;Malignant Neoplasms;maternal obesity;Measures;Metabolic Diseases;Modeling;multimodality;Myocardial Infarction;neural;neurobehavioral;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity risk;obesity treatment;Participant;Pattern;Peptides;Perception;Persons;Premature Mortality;Prevention program;Process;Prospective Studies;recruit;Regulation;Reporting;Research;Research Design;response;Rewards;Risk;Satiation;Scanning;Signal Transduction;Structure;Structure of postcentral gyrus;Taste Perception;Testing;Thinness;Visceral fat;Weight Gain;weight loss program;Youth

PROJECT_TITLE: Relation of individual differences in fMRI-Assessed Satiation Signaling to Obesity Risk and Future Weight Gain

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: MILWAUKEE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Targeting pancreatic β cell autophagy can potentially restore insulin secretion and reverse diabetes, but we know little how autophagy operates in β cells. Our preliminary data suggest that a subfamily of large-GTPase dynamins (dynamin-2 and dynamin-3) regulate β cell autophagy, a process known to protect β cells against metabolic stress. We will investigate the underlying molecular mechanisms using advanced imaging techniques, biochemistry assays, and unique genetic models to understand dynamin-regulated β cell autophagy in healthy conditions and under diabetic stress.

PI_NAMEs: LOU, XUELIN  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Acetylation;Affect;American;Animals;Autophagocytosis;Beta Cell;Binding;Biochemical;Biochemistry;Biological Assay;blood glucose regulation;Cell Line;Cell Physiology;Cellular biology;Chronic;Cytoprotection;Data;Defect;design;Development;Diabetes Mellitus;diabetes pathogenesis;diabetic;Diet;Dynamin;Dynamin 2;Dynamin III;Eating;Endocytosis;Epidemic;Failure;Fasting;feeding;Genes;Genetic;genetic approach;Genetic Models;Guanosine Triphosphate Phosphohydrolases;Image;Imaging Techniques;Impairment;In Vitro;in vivo;innovation;insight;Insulin;insulin secretion;interdisciplinary approach;interest;Investments;islet;Knowledge;Lead;live cell imaging;Lysosomes;Mediating;Membrane;Metabolic stress;Methodology;Methods;Microtubules;Modification;Molecular;mouse model;Mus;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Organ;pathogen;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Physiological;Play;preservation;prevent;Process;Protein Isoforms;Recurrent disease;Regulation;response;Role;Signal Transduction;Source;Stress;Structure of beta Cell of islet;superresolution imaging;superresolution microscopy;Testing;Therapeutic;therapeutic target;Time;Tissues;tool;trafficking;Transplantation;Transportation;type I and type II diabetes;Vacuole;Work

PROJECT_TITLE: Dynamin function in pancreatic beta-cell autophagy

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: LINCOLN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE Fe-S proteins play a central role in redox control and stress response, which is crucial for human health and the survival of bacterial pathogens during infection. Our structural and mechanistic investigations of Fe-S proteins involved in redox sensing and regulation will be instrumental in the understanding of disease progression and the design of new therapeutic strategies against diverse pathogens.

PI_NAMEs: ZHANG, LIMEI  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Address;Anabolism;Bacterial Infections;Binding;Binding Proteins;Biochemical;biological adaptation to stress;Biological Process;Cell Physiology;Cell Survival;cofactor;Communicable Diseases;design;Diabetes Mellitus;Disease;Disease Progression;DNA Repair;experience;Family;Genetic Transcription;Genus Mycobacterium;Goals;Health;Hemostatic function;Homeostasis;Human;improved;In Vitro;in vivo;Infection;Investigation;Iron;Iron-Sulfur Proteins;Life;Ligands;Link;Maintenance;Malignant Neoplasms;Mediating;Metals;Molecular;Molecular Biology;Molecular Weight;monomer;Mycobacterium tuberculosis;novel;novel therapeutic intervention;Oxidation-Reduction;Oxidative Stress;Oxygen;pathogen;pathogenic bacteria;Physiological;Play;programs;Proteins;Regulation;repaired;Research;response;RNA metabolism;Role;skills;Stress;Structural Biochemistry;Structure;Sulfhydryl Compounds;Sulfur;System;transcription factor;Transcriptional Regulation

PROJECT_TITLE: Structures and Mechanisms of Iron-Sulfur Proteins in Redox Control and Stress Response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: CA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE. In this proposal we will determine 1) how hypoxia primes DCCs for dormancy, 2) how NG2+/Nestin+ MSCs orchestrate dormancy niches and how aging affects these mechanisms and 3) how tissue resident lung alveolar macrophages (AMs) dictate DCC fate and how aging impacts the function of these niches.

PI_NAMEs: AGUIRRE-GHISO, JULIO A. (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Adopted;Affect;Aftercare;age effect;Aging;Alveolar Macrophages;Automobile Driving;BMP7 gene;Bone Marrow;Breast;cancer cell;Cancer Model;Cancer Patient;cancer therapy;Carcinoma;Cell Survival;Clinical Trials;CSPG4 gene;Cues;Data;Epigenetic Process;Evolution;Genes;Genetic Transcription;Goals;Hematopoietic stem cells;Homeostasis;Hypoxia;imprint;Inflammatory;Link;Lung;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Mesenchymal;Mesenchymal Stem Cells;Metastatic Neoplasm to the Bone;Metastatic Neoplasm to the Lung;Methods;Monitor;Neoplasm Metastasis;nestin protein;novel;old mice;Organ;pathological aging;pluripotency;Primary Lesion;Primary Neoplasm;programs;Proteins;Publishing;rational design;relapse prevention;Residual Cancers;response;Signal Induction;Signal Transduction;Site;stem cell function;stem cell niche;Systemic disease;Testing;TGFB2 gene;Therapeutic;therapy development;Tissues;Transforming Growth Factor Beta 2;Tretinoin;tumor hypoxia;Up-Regulation;WNT5A gene;Work

PROJECT_TITLE: Functional Determinants of Metastatic Dormancy

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention;Sexually Transmitted Infections

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Sporadic Alzheimer’s disease (AD) has a massive global burden and likely multiple etiologies, which may include the involvement of infectious microbes, an association that has garnered renewed attention amidst the ongoing SARS-CoV-2 pandemic, given the neurological and neurocognitive features of COVID-19. Here, we propose to leverage single-nucleus sequencing technologies to investigate the cell type-specific effects of viral gene products, including HSV1 latency-associated transcripts (LATs) and the SARS-CoV-2 Spike protein, in AD model systems, exploring the hypothesis that they can modulate transcriptional events in the host associated with sporadic AD. Further, we will characterize the distinct genomic and non-genomic actions of the HSV1 LATs that may reveal new opportunities for therapeutic intervention or exploitation.

PI_NAMEs: ROSENFELD, MICHAEL G (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: 2019-nCoV;Address;Affect;aged;Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Anti-Inflammatory Agents;Appearance;Astrocytes;Attention;Binding;Biological Models;biological specimen archives;Brain;Cell Death;Cell Nucleus;cell type;Cells;Characteristics;Collaborations;COVID-19;COVID-19 neurocognitive sequelae;COVID-19 pandemic;Data;Dementia;Deposition;Disease Progression;Disease susceptibility;DNA;Double-Stranded RNA;Down-Regulation;Ectopic Expression;Endogenous Retroviruses;Enhancers;Etiology;Event;extracellular;Female;Future;Gene Cluster;Gene Expression;Gene Expression Profile;Gene Proteins;gene repression;Genes;Genetic;Genetic Risk;Genetic Transcription;Genetic Variation;Genome;genome wide association study;genome-wide analysis;Genomics;Glean;glial activation;Herpes Simplex Infections;Herpesvirus 1;Human;human induced pluripotent stem cells;Immune;Impaired cognition;Incidence;Individual;Inflammatory;Innate Immune Response;insight;Intervention;Investigation;latency associated transcript;latent infection;Link;male;Microbe;Microglia;Molecular;Mus;Neurocognitive;Neurofibrillary Tangles;Neuroglia;neuroinflammation;Neurologic;neuron loss;Neuronal Dysfunction;Neurons;neuropathology;neurotoxic;non-genomic;novel;novel strategies;Nucleic Acid Regulatory Sequences;outcome prediction;Pathologic;Pathway interactions;Phosphotransferases;Predisposition;Process;programs;promoter;Proteins;Public Health;reactivation from latency;recruit;Regulation;Regulatory Element;Reporting;Repression;Research;Retrotransposon;risk variant;Role;Sampling;SARS-CoV-2 spike protein;Sentinel;single nucleus RNA-sequencing;Susceptibility Gene;Technology;Testing;Therapeutic;Therapeutic Intervention;Transcript;Transcription Alteration;transcription factor;Trees;United States;Untranslated RNA;Up-Regulation;Viral;Viral Genome;Viral Proteins;Virus;Virus Diseases;Zinc Fingers

PROJECT_TITLE: Viral IncRNAs Regulate Host Genomic Transcriptional Programs Associated with Sporadic Alzheimer's Disease


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: CHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative  Synthetic methods that rapidly generate complex organic molecules are critical for the development of selective biological probes and therapeutics. The overarching goal of this project is to explore transition metal redox catalysts for the reductive generation of carbene equivalents from readily available gem-dihalo starting materials. Using this approach, we will develop cycloaddition reactions that form odd-membered rings and vinylidene carbon–carbon coupling reactions that form chiral building blocks.

PI_NAMEs: UYEDA, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Transition Metal Catalyzed Reductive Carbene Transfer Reactions


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Epilepsy;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Precision Medicine

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE The overall goal of this program is to use genetically engineered mice to advance the understanding of Developmental and Epileptic Encephalopathies, a series of individually rare but collectively substantial and debilitating neurological disorders of childhood, and further to develop the application of gene therapies as interventions. Success in this program has the potential to directly influence more effective treatment in the clinical setting.

PI_NAMEs: SANDS, TRISTAN T (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acceleration;Address;Adult;Age;Attention;Behavior;Brain;Brain Diseases;cell type;Childhood;Childhood Neurological Disorder;Clinic;Clinical;clinical application;Collaborations;collaborative approach;comorbidity;Complex;Dedications;design;Development;developmental genetics;Disease;effective therapy;Engineering;Enterobacteria phage P1 Cre recombinase;Epilepsy;epileptic encephalopathies;epileptiform;Etiology;exome sequencing;expectation;Family;gene discovery;Gene Expression;gene therapy;Genes;Genetic;Genetic Determinism;genetic disorder diagnosis;Genetic Heterogeneity;Genetic Models;Genetic Transcription;Genetically Engineered Mouse;Goals;Human;In Situ;in vivo;Individual;insight;Intervention;Laboratories;Methods;Modeling;Molecular;Monitor;mouse genetics;mouse model;Mus;Mutation;Nature;Nervous System Disorder;Neurodevelopmental Disorder;Neurologic;Neurons;novel therapeutic intervention;novel therapeutics;Paper;Pathogenicity;Pediatric Hospitals;personalized approach;personalized medicine;Pharmacology;Pharmacotherapy;Phenotype;precision medicine;Precision therapeutics;programs;Publishing;pup;RNA;Role;Seizures;Series;side effect;success;Symptoms;System;Testing;Time;tool;transcriptome;transcriptome sequencing;Variant;Vermont;Work

PROJECT_TITLE: Genetic Determinants of Epilepsy in Murine Systems

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Genetics;Mental Health;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: The COVID-19 pandemic is an unwanted natural experiment in the deleterious effects of stress and social isolation on older Americans’ cognitive and emotional health and risk for Alzheimer’s Disease (AD). This project will advance our knowledge of the impact of social isolation and loneliness on older adults, including mechanisms by which these stressors produce negative cognitive, emotional, and brain health changes and how we can prevent those negative effects.

PI_NAMEs: DINIZ, BRENO SATLER;LENZE, ERIC J (contact);WETHERELL, JULIE L

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Adult;age effect;Age-associated memory impairment;aged;Aging;Alzheimer's Disease;Alzheimer's disease risk;American;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Anxiety;Atrophic;Behavioral;Biological;Biological Aging;Biological Markers;Brain;brain health;Buffers;Clinical;Clinical Trials;Cognition;Cognitive;cognitive control;cognitive function;cognitive performance;coping;COVID-19 pandemic;DNA Methylation;Ecological momentary assessment;Emotional;Enrollment;Episodic memory;executive function;Exercise;Exercise Test;follow-up;Functional Magnetic Resonance Imaging;Funding;Genotype;Goals;Health;Health education;high risk;Hippocampus;Hydrocortisone;Individual;innovation;Intervention;intervention effect;Knowledge;late life;Life Style;lifestyle intervention;Loneliness;Magnetic Resonance Imaging;Measures;Medical;Memory;Mental Depression;Methods;mindfulness;mindfulness-based stress reduction;Modeling;Molecular;Morbidity - disease rate;Natural experiment;negative affect;Neurobiology;neuroimaging;Neuropsychology;novel;older adult;Outcome;pandemic disease;pandemic impact;pandemic stress;Participant;Peripheral;Personal Satisfaction;Phase;Physiological;Plasma;post-pandemic;prevent;protective effect;psychologic;Public Health;Randomized;Research;resilience;Resources;Rest;risk variant;Salivary;SARS-CoV-2 exposure;satisfaction;senescence associated secretory phenotype;sleep quality;smartphone based assessment;social;social contact;social engagement;Social isolation;Stress;stress reduction;stressor;Structure;Testing;Time;United States National Institutes of Health;virtual;Well in self

PROJECT_TITLE: Resilience and brain health of older adults during the COVID-19 pandemic


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Reproducing human early development in vitro allows the precise dissection of normal and pathological processes. Here we use a synthetic approach to study human neurulation, the process by which the central nervous system and other ectodermal derivatives are positioned. This will unveil the basic biology of cell fate specification in models of early human embryos, and thus highlight key steps that are likely to be dysfunctional in disease states.

PI_NAMEs: BRIVANLOU, ALI H (contact);SIGGIA, ERIC D.

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Adhesives;Automobile Driving;Basic Science;Biological Assay;Callithrix;cell assembly;cell fate specification;cell type;Cells;Cellular biology;Central Nervous System;Cerebrum;Chick Embryo;Clinic;clinical application;Coin;combinatorial;CRISPR/Cas technology;data integration;Development;Developmental Biology;direct application;Disease;Dissection;Ectoderm;Ectoderm Cell;Embryo;Environment;Epidermis;Event;experimental study;fetal;Fibroblast Growth Factor;Generations;Genes;Germ Layers;Heterogeneity;Human;human embryonic development;human embryonic stem cell;human fetus tissue;human model;Image;In Vitro;in vivo;intercellular communication;Knowledge;Link;mathematical model;Mediating;Modeling;Molecular;Molecular Profiling;Morphogenesis;neural;Neural Crest;Neurula;new technology;Organoids;Pathologic Processes;Pattern;Phase;Population;Positioning Attribute;primate development;Process;progenitor;Protocols documentation;Reporter;Reproducibility;Resolution;Sampling;self organization;Side;Signal Transduction;single-cell RNA sequencing;spatiotemporal;Specific qualifier value;Specificity;Stains;Standardization;Structure;Time;Tissues;Validation

PROJECT_TITLE: Micropattern differentiation and morphogenesis of the human ectoderm

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: MADISON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE Collective cell migration is essential in multiple processes in human health, such as wound healing, cancer invasion, and tissue development. The proposed research will advance experimental methods for measuring cell forces and apply them in both in vitro and in vivo cell collectives. The results will form the basis for frameworks from which to organize understanding and to formulate modeling methods to predict how biochemical interventions affect the motion, which would enable numerous advances, such as new methods to accelerate wound healing, slow down cancer cell invasion, and control the size and shape of engineered tissues.

PI_NAMEs: NOTBOHM, JACOB K (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Acceleration;Affect;Area;Award;Biochemical;Biological;Biology;biophysical techniques;cancer cell;Cell Culture System;cell motility;Cells;cellular imaging;chronic wound;Computer Models;Data Science;design;Development;Disease Progression;driving force;experimental study;Generations;Goals;healing;Health;Human;improved;In Vitro;in vivo;Intervention;Invaded;Malignant Neoplasms;Mathematics;Measures;Methodology;Methods;migration;Modeling;Motion;Physics;Process;programs;Research;response;Shapes;Signal Transduction;System;Time;Tissue Engineering;Tissues;transmission process;Variant;wound healing

PROJECT_TITLE: Revealing forces driving collective cell migration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-L(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative The endogenous circadian system plays an important role in regulating glucose tolerance, beta- cell function, diet-induced thermogenesis, and potentially fat tolerance. Levering this insight, we have developed a novel and translational approach that combines the concepts of the importance of WHAT we eat with the importance of WHEN we eat. This research will determine whether shifting high-carb intake to the biological morning and high-fat intake to the biological evening – without disrupting sleep, extending fasting duration, or changing 24-h caloric or macronutrient intake – can increase glucose tolerance, diet-induced thermogenesis, and fat tolerance, both under circadian aligned and misaligned conditions, with great translational promise for shift workers and the general population.

PI_NAMEs: SCHEER, FRANK A (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Address;Area Under Curve;balance testing;Behavioral;Beta Cell;Biological;Caloric Restriction;Carbohydrates;Cell Physiology;Chronic;circadian;Circadian desynchrony;circadian pacemaker;Data;design;diabetes risk;Diet;Eating;Evidence based intervention;experimental study;Fasting;Fatty acid glycerol esters;General Population;Glucose;glucose tolerance;Goals;Health;impaired glucose tolerance;Indirect Calorimetry;insight;insulin sensitivity;Intake;Intervention;Knowledge;Life Style;Lipids;Macronutrients Nutrition;Measures;Metabolic;Metabolic Marker;Metabolism;Modeling;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;novel strategies;Oral;oxidation;Phase;Play;Prevalence;Protocols documentation;Randomized;Randomized, Controlled Trials;Research;Research Design;Risk;Risk Factors;Role;Schedule;shift work;Sleep disturbances;Socioeconomic Status;Stress;System;Testing;Thermogenesis;Time;translational approach;Triglycerides;Vulnerable Populations;Wakefulness;Work

PROJECT_TITLE: Effect of temporal distribution of macronutrient intake on metabolism


ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE The overall goal of this project is to determine what role estrogen receptor α plays in determining lifespan, healthspan, disease burden, and responsiveness to 17α-estradiol, a lifespan-extending compound, in both male and female mice. We will study the effects of whole body and hypothalamic-specific ablation of estrogen receptor α, the stimulation of estrogen receptor α containing cells in the hypothalamus, and the ablation of endogenous estrogen production. This project will provide significant insight into sexually divergent mechanisms of aging, which is currently a critical barrier to developing sex-specific novel treatments aimed at combating aging and chronic diseases in humans.

PI_NAMEs: STOUT, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: 4-vinylcyclohexene diepoxide;Ablation;Acute;adenovirus mediated delivery;Affinity;Age Months;aged;Aging;aging mechanism;Binding;blood glucose regulation;Brain;burden of illness;Caloric Restriction;Cells;Chronic;Chronic Disease;Coupled;Dependovirus;designer receptors exclusively activated by designer drugs;Disease;Dose;druggable target;Eating;ESR1 gene;Estradiol;Estrogen Receptor 2;Estrogen Receptors;Estrogens;extend lifespan;Fatty Liver;Female;frailty;Genetic;genetic approach;Geropathology;glucose tolerance;Goals;Health;Health Benefit;healthspan;Homeostasis;Human;Hypothalamic structure;improved;in vivo evaluation;Incidence;indexing;inflammatory marker;Infusion procedures;insight;insulin sensitivity;Intervention;Knock-out;Knockout Mice;Knowledge;Laboratories;life span;Link;Liver;Longevity;LoxP-flanked allele;male;Mediating;Metabolic;Metabolism;middle age;Molecular Target;Mus;Neurons;novel;Obesity;Outcome;Ovarian;Ovariectomy;Pathology;Pathway interactions;pharmacologic;Play;Production;programs;Rattus;receptor;Reporting;Research;response;Role;sex;Sex Differences;sexual dimorphism;Signal Transduction;Sirolimus;Site;Testing

PROJECT_TITLE: Role of estrogen receptor-a in aging and sex-specific responses to 17a-estradiol

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative Population-based evidence on the cardiovascular (CV) effects of e-cigarette use is sparse. The proposed research will use high-quality population data with state-of-the-art causal inference methods to assess the effects of e-cigarette use on incident CV events, examine urinary exposure biomarkers to identify specific components of e-cigarette aerosols that mediate CV harm, and stratify adult CV risk according to biomarker signatures and their association with e-cigarette use behaviors and product characteristics. The study will generate critically needed evidence on the CV health risks of e-cigarette use, which may inform new regulatory standards for product safety and guide primary and secondary public health interventions that aim to reduce tobacco-related CV harm.

PI_NAMEs: STOKES, ANDREW  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Abstinence;Acute;Adult;Aerosols;Applications Grants;Aromatic Polycyclic Hydrocarbons;Behavior;Biological Markers;biomarker signature;Biometry;Blood Pressure;cardiovascular disorder epidemiology;cardiovascular effects;cardiovascular health;cardiovascular injury;cardiovascular risk factor;Cardiovascular system;career;Characteristics;Cholesterol;Cigar;Cigarette;cigarette smoking;cigarillos;Clinical;Clinical Sciences;Coronary heart disease;Data;Data Science;Data Set;design;Development;Diagnosis;e-cigarette aerosols;early-career faculty;Electronic cigarette;electronic cigarette use;Etiology;Event;evidence base;Family;Frequencies;Funding;Future;Goals;Health;Health Professional;Heart failure;high risk population;In Vitro;in vivo;Inflammation;innovation;Intervention;Knowledge;Label;Link;Long-Term Effects;Marketing;Measures;Mediating;Mediation;Mediator;Mentored Research Scientist Development Award;Mentors;Mentorship;Metals;Methods;Modeling;multidisciplinary;Myocardial Infarction;National Health and Nutrition Examination Survey;Nicotine;Nitrosamines;non-cigarette tobacco product;novel;Outcome;Oxidative Stress;Patient Self-Report;Pattern;Policies;Population;Population Assessment of Tobacco and Health;population based;population health;Population Research;pre-clinical;Probability;Program Development;programs;Prospective, cohort study;public health intervention;Randomized, Controlled Trials;Research;Research Personnel;Residual state;Risk;Risk Factors;Role;Safety;Sample Size;Scientist;Secure;Series;skills;Smokeless Tobacco;Statistical Methods;Stroke;Structural Models;Testing;Thrombosis;Time;Tobacco;tobacco products;tobacco regulatory science;Tobacco use;Training;Training Activity;Translational Research;Triglycerides;United States Food and Drug Administration;United States National Institutes of Health;urinary;volatile organic compound;Work

PROJECT_TITLE: Novel Methods for Evaluating the Association of Electronic Cigarette Use with Cardiovascular Health


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The primary cilium is an antenna-like cellular protrusion that allows cells to respond to external signals that instruct cell growth, differentiation, and proliferation. Aberrant ciliary signaling causes pediatric syndromes and can promote cancer development, while imbalances in cilium assembly versus disassembly are commonly observed in tumors and may contribute to uncontrolled cell growth. This proposal aims to improve our understanding of the roles of primary cilia in health and disease by elucidating the molecular pathways that underlie cilium formation, function, and disassembly.

PI_NAMEs: BRESLOW, DAVID KING (contact)

PROJECT_TERMS: Biochemical;Biogenesis;Biological Assay;Cell Cycle;Cell Cycle Progression;cell growth;Cells;Childhood;Cilia;ciliopathy;cilium biogenesis;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;Defect;Development;Disease;Embryonic Development;Erinaceidae;experimental study;gene product;Genes;Genetic Screening;genome wide screen;Health;Homeostasis;Human body;Image;improved;In Vitro;insight;Knowledge;Link;Malignant Neoplasms;Mediator;Molecular;Monitor;novel strategies;Organelles;Pathway interactions;Perception;Permeability;Physiological;Proliferating;protein transport;Proteins;rab GTP-Binding Proteins;reconstitution;Role;screening;Screening procedure;Sensory;Signal Pathway;Signal Transduction;Structure;Structure of ciliary processes;Surface;Syndrome;System;Tissues;tumor;tumorigenesis;uncontrolled cell growth;Work

PROJECT_TITLE: Mechanisms of Primary Cilium Assembly and Disassembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Women's Health Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: NARRATIVE Cancer therapies frequently fail because the patients’ tumors adapt to treatment and become both therapy- resistant and more aggressive. Preventing this process could have a transformative impact on cancer treatment outcome. Here we propose to investigate whether inhibition of Mediator kinase proteins, which are involved in changing cellular gene expression, would prevent the development of therapy resistance and more aggressive properties in a major type of breast cancers.

PI_NAMEs: BROUDE, EUGENIA V;CHEN, HEXIN ;RONINSON, IGOR B (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: acquired drug resistance;Affect;Antineoplastic Agents;Breast Cancer cell line;Breast Carcinoma;cancer drug resistance;cancer stem cell;cancer therapy;Cell Line;Cells;clinical development;clinically relevant;Derivation procedure;Development;Drug resistance;Drug Targeting;Epithelium;ERBB2 gene;exome sequencing;Exposure to;Gene Expression;gene induction;Genetic Transcription;genetically modified cells;Genomics;Growth;Heterogeneity;Human;Human Cell Line;Immune;Immune system;Immunocompetent;immunodeficiency;Immunodeficient Mouse;In Vitro;in vivo;inhibitor;inhibitor therapy;kinase inhibitor;lapatinib;Malignant Breast Neoplasm;Malignant Epithelial Cell;Mediator;Mesenchymal;MicroRNAs;miRNA expression profiling;Mouse Mammary Tumor Virus;mouse model;Mus;Mutagenesis;mutant;Neoplasm Metastasis;neoplastic cell;non-genetic;novel;novel drug class;novel therapeutics;Paclitaxel;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Phosphorylation;Phosphotransferases;Population;pre-clinical;prevent;Prevention;Process;programs;Property;Protein Isoforms;Protein Kinase;prototype;Remission Induction;Resistance;Resistance development;Role;Signal Transduction;Signal Transduction Pathway;single-cell RNA sequencing;Stromal Cells;Testing;therapy development;therapy resistant;transcription factor;transcriptional reprogramming;transcriptome sequencing;transcriptomics;Treatment outcome;tumor;tumor growth;tumor initiation;tumor progression;Tumor Promotion;tumor xenograft;Xenograft procedure

PROJECT_TITLE: Preventing adaptive drug resistance through Mediator kinase inhibition


NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Genetics;Infectious Diseases;Natural Products

ORG_DEPT: ZOOLOGY

PHR: Public Health Relevance Statement Nature continues to drive the design of new drug leads through the inherent capacity of naturally produced chemicals to treat human disease. New tools in genomics and synthetic biology now allow for the accelerated discovery and engineering of novel natural product compounds from microbes and their DNA. We propose to combine poorly studied biological resources, such as deep-sea marine microbes, with modern genome mining strategies to increase the prospects for the discovery of new drug leads.

PI_NAMEs: JENSEN, PAUL R;MOORE, BRADLEY S (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acceleration;Actinobacteria class;Address;Anabolism;Antibiotics;antimicrobial;Aquaculture;Bacteria;Bacterial natural products;Bioinformatics;Biological;chemical group;Chemicals;Chemistry;Clinical;Cloning;Collaborations;Collection;Communicable Diseases;comparative genomics;Crude Extracts;deep ocean;design;design,build,test;Development;DNA;drug discovery;emerging antibiotic resistance;Engineering;Environment;Enzymes;Evolution;Expeditions;experimental study;Fractionation;Future;Gene Cluster;gene synthesis;Genes;Genetic;Genetic Transcription;Genome;Genomics;Gifts;Goals;halogenation;Human;human disease;Hybrids;innovation;insight;isoprenoid;Knowledge;Laboratories;Lactones;Lead;Learning;Link;Malignant neoplasm of brain;marine;Marine Sediment;Medicine;metagenome;Metagenomics;meter;Methods;Microbe;microbial;microbial genome;Microbiology;Mining;Modeling;Modernization;Natural product discovery;Natural Products;Natural Products Chemistry;Nature;novel;novel therapeutics;Oceanography;Oceans;Orphan;Peptide Hydrolases;Pharmaceutical Preparations;phase III trial;Productivity;programs;Proteasome Inhibitor;public health relevance;Research;resistance gene;Resources;salinosporamide A;Sampling;Science;screening program;Signaling Molecule;small molecule;synthetic biology;Synthetic Genes;Taxon;Techniques;Testing;Time;tool;Vanadium;Virulence;Virulence Factors

PROJECT_TITLE: Natural Product Genome Mining

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Mental Health;Neurosciences;Pediatric

ORG_CITY: RENO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Program Director/Principal Investigator (Last, First, Middle): HOY, JENNIFER, LYN PROJECT NARRATIVE This work will identify neural circuit mechanisms underlying the development of visual stimulus detection and pursuit behavior. Appropriately orienting towards salient stimuli and filtering out distraction is required for healthy visual cognition and attention in adults and is sensitive to developmental experience. Autism, schizophrenia, ADHD and generalized anxiety are disorders rooted in perturbed development and are associated with deficits in the ability to properly modulate visuospatial orienting behavior.

PI_NAMEs: HOY, JENNIFER LYN (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Adolescent;Adult;Age;age related;age related changes;Animals;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;behavior change;Behavioral Assay;Biological Assay;Calcium;Cell Physiology;cell type;Cells;Complex;Data;density;Detection;Development;developmental disease;Disease;distraction;early experience;Electrophysiology (science);Environment;experience;extracellular;Freezing;Frequencies;Generalized Anxiety Disorder;Genes;Genetic;Goals;Image;in vivo;Individual;Insecta;interest;Knowledge;Learning;Life;Link;Location;LYN gene;Mammals;Measures;Mediating;Modification;mouse model;Mus;Nervous System Disorder;neural;neural circuit;neural patterning;Neurodevelopmental Disorder;Neurons;novel;optogenetics;Output;Pathway interactions;Pilot Projects;Play;Population;Post-Traumatic Stress Disorders;postnatal;Primates;Principal Investigator;Process;programs;response;Retina;Role;Schizophrenia;Sensory;Site;Space Perception;Speed;Stimulus;Structure;superior colliculus Corpora quadrigemina;Synapses;targeted treatment;Time;tool;Ultrasonography;ultrasound;virtual reality environment;Virus;vision development;Visual;Visual attention;visual cognition;visual information;Visual Perception;visual plasticity;visual processing;visual stimulus;Visual System;Visuospatial;Work

PROJECT_TITLE: Experience-Dependent Plasticity in Superior Colliculus and Natural Visual Behavior

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Pain Research;Patient Safety;Pediatric;Prevention;Screening and Brief Intervention for Substance Misuse;Substance Misuse;Substance Misuse Prevention

ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Substance use among adolescents (ADOL) is prevalent, yet grossly undertreated. Wisdom tooth extraction is a common, acutely painful procedure for ADOL that represents an opportune time to identify ADOL substance use and engage ADOL in brief intervention due to shared risk factors between SU and pain, the potential for exposure to prescription opioids for pain management, and because substance use is associated with increased risk for post-operative complications. This study aims to adapt and evaluate a novel, scalable pre- surgical brief intervention for ADOL with substance use undergoing oral surgery (i.e. wisdom tooth extraction) that dually targets substance use and pain coping.

PI_NAMEs: PIELECH, MELISSA  (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: 15 year old;Academy;acceptability and feasibility;Accident and Emergency department;Acute;Acute Pain;addiction;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Age;Age of Onset;Alcohols;American;Attenuated;Behavior;Behavior Therapy;brief intervention;Child Psychology;Childhood;clinical encounter;Clinical Trials;comparison control;coping;craving;Data Analyses;Dental;Dental Care;Dental Clinics;Dentists;design;Development;Ecological momentary assessment;Education;Enrollment;Ensure;Environment;Evaluation;Event;evidence base;Evidence based intervention;experience;Exposure to;Feedback;Focus Groups;follow up assessment;Frequencies;Future;Health;high risk;Impairment;implementation context;improved;improved outcome;Influentials;informant;innovation;integrated care;interdisciplinary collaboration;Intervention;intervention refinement;Interview;Knowledge;Leadership;Life;marijuana use;Measures;Medical;Mentors;Mentorship;Methods;non-opioid analgesic;novel;Operative Surgical Procedures;Opioid;opioid misuse;opioid use;Oral Surgeon;Oral Surgical Procedures;Outcome;Pain;Pain intensity;Pain management;Parents;Patient Self-Report;Patients;Pediatrics;Perioperative;Persons;Phase;Postoperative Complications;Postoperative Pain;Postoperative Period;Practice Management;prescription opioid;primary care setting;Procedures;Provider;psychosocial;Public Health;Randomized, Controlled Trials;Recommendation;Records;reduced substance use;Research;Rhode Island;Risk;Risk Factors;risk minimization;risk mitigation;risk sharing;satisfaction;screening;screening and brief intervention;Screening procedure;screening, brief intervention, referral, and treatment;skills;Structure;Substance Addiction;substance use;Substance Use Disorder;substance use treatment;substance user;Testing;therapy development;Time;Tooth Extraction;Training;Universities;wisdom tooth;Work;young adult;Youth

PROJECT_TITLE: Adapting and evaluating an integrated intervention for adolescent substance use and pain during oral surgery

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: TUCSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Noise trauma can lead to tinnitus and auditory processing disorders. PV neuron loss is implicated in those auditory pathologies. We propose to systematically characterize noise-induced PV neuron dysfunction and examine the roles of TNFR1 and TNFR2 in PV neuron dysfunction as potential treatment targets.

PI_NAMEs: BAO, SHAOWEN  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acute;Antibodies;Apoptosis;Auditory;Auditory area;Auditory Perceptual Disorders;auditory processing;Behavioral;Brain Diseases;Cell Death;Cell Death Process;Cell Differentiation process;Cell model;Cell Survival;Cells;Custom;cytokine;Cytoprotection;design;Disease;experimental study;Fluorescence;Frequencies;Functional disorder;Functional impairment;Gene Expression;hippocampal pyramidal neuron;Impairment;In Situ Nick-End Labeling;Inflammatory;Interneurons;knock-down;Link;Measures;Mediating;Membrane;Methods;Mus;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neuronal Dysfunction;Neurons;Noise;noise exposure;noise trauma;optogenetics;Output;Parvalbumins;patch clamp;Pathology;Phenotype;Phosphorylation;prevent;Procedures;promoter;Receptors, Tumor Necrosis Factor, Type II;Recovery;Research;Resources;RIPK3 gene;Rodent Model;Role;Slice;small hairpin RNA;Stains;Synapses;Testing;Time;Tinnitus;Tissues;TNF gene;TNFRSF1A gene;TNFRSF1B gene;Transfection;Trauma;Traumatic Brain Injury;Viral Vector

PROJECT_TITLE: Noise  Trauma-Induced Cortical PV Neuron Dysfunction

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Prevention

PHR: Project Narrative Environmental exposures play a leading role in the development of disease. We propose to build a metabolomics platform that will greatly enhance our ability to measure environmental exposures in humans and assess their biological consequences in zebrafish. Our platform will provide insight into how chemicals in the environment lead to adverse health effects.

PI_NAMEs: PATTI, GARY J (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Address;Adverse effects;Biochemical;Biochemical Pathway;Biological;Blood;Chemical Exposure;Chemicals;Development;Disease;Embryo;Environment;Environmental Exposure;Environmental Health;Goals;Health;Human;human disease;human subject;insight;interest;Laboratories;Lead;liquid chromatography mass spectrometry;Measures;Metabolism;metabolome;metabolomics;metabolomics resource;Mission;Molecular;Names;new technology;novel;Organ;Pathway interactions;Phenotype;Play;prevent;programs;Research;Resources;response;Role;Signal Transduction;small molecule;Technology;Testing;toxicant;Zebrafish

PROJECT_TITLE: Developing Metabolomic Technologies to Advance Environmental Exposure Analysis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Narrative Visual processing in the cortex is “split” between right vs left visual hemifields yet visual cognition seems seamless, not split down the middle. Our project uses bilateral multiple-electrode recordings to test hypotheses about how the cerebral hemispheres function together and “heal” this split. Our results will give insights into the neural basis of visual cognition and into disorders of interhemispheric interaction, such as dyslexia and hemispatial neglect.

PI_NAMEs: MILLER, EARL K (contact)

PROJECT_TERMS: Air;Attention;Attention deficit hyperactivity disorder;Back;Behavioral;Bilateral;Binding;Cerebral hemisphere;Cognition;Communication;Conscious;Contracts;Contralateral;cost;Delayed Memory;Disease;Dyslexia;Electrodes;experimental study;Eye Movements;Feeds;gaze;healing;Hemispatial Neglect;Human;Infrastructure;insight;interhemispheric transfer;Left;Maintenance;Monkeys;Nature;neural;neurophysiology;neurotransmission;object motion;Parietal;Parietal Lobe;Prefrontal Cortex;Role;Saccades;Schizophrenia;Sensory;Short-Term Memory;Speed;Sports;Stimulus;Stretching;System;Task Performances;Testing;Time;Visual;visual cognition;Visual Cortex;visual information;visual processing;Work

PROJECT_TITLE: Interhemispheric coordination and transfer of visual information


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Dissemination and Implementation Research;Mental Health;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE This K23 proposal will enhance the implementability and establish the feasibility, acceptability, and credibility of a mindfulness-based lifestyle program, My Healthy Brain (MHB), to modify multiple risk factors for Alzheimer’s Disease and Related Dementias (ADRD) in older adults with subjective cognitive decline (SCD) and difficulties with health behavior adherence. Interventions tailored for SCD represent a critical window of opportunity for ADRD prevention, while cognitive symptoms are at the earliest stage, yet prior trials targeting multiple lifestyle factors had limited adherence, are time-intensive, and failed to modify behaviors. A brief mindfulness-based lifestyle program, delivered via live video and mobile health technology, is a scalable approach to engage millions of at-risk older adults with SCD (endorsed by half of individuals age 65 or above) in sustained lifestyles to prevent ADRD and optimize healthy aging.

PI_NAMEs: MACE, RYAN ANDREW (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: acceptability and feasibility;actigraphy;Address;Adherence;Age;Aging;Alcohols;Alzheimer disease prevention;Alzheimer's disease related dementia;Alzheimer's disease risk;Attention;Award;Awareness;Behavior;behavior change;Behavior Therapy;Benchmarking;biological adaptation to stress;Brain;Cardiovascular Diseases;cardiovascular risk factor;Caring;Cellular Phone;Chronic stress;Clinic;Clinical;Clinical Trials;Cognition;Cognitive;cognitive control;cognitive function;cognitive interview;Complement;compliance behavior;Dementia;dementia risk;Detection;Education;Educational process of instructing;efficacy testing;efficacy trial;Elderly;Elements;Enhancement Technology;Environment;Exercise;experience;Feedback;Focus Groups;Funding;General Hospitals;global health;Goals;Grant;Habits;Health;Health behavior;health data;Health Technology;healthy aging;healthy lifestyle;human old age (65+);Hyperphagia;Impaired cognition;implementation barriers;implementation framework;implementation science;improved;Incidence;Individual;interest;International;Intervention;Interview;Life Expectancy;Life Style;lifestyle factors;lifestyle intervention;Link;Massachusetts;Medical;medical schools;Medical Staff;Mental Health;Mentors;Mentorship;Methodological Studies;Methodology;mHealth;Mind-Body Intervention;mindfulness;mindfulness intervention;Modeling;modifiable lifestyle factors;Monitor;multidisciplinary;Myristica fragrans;Neurobehavioral Manifestations;new technology;novel;older adult;Outcome;Palliative Care;patient engagement;Patient Self-Report;Patients;Peer Review;Peripheral;personalized strategies;Persons;Physicians;pilot test;Population;Population Intervention;Prevalence;prevent;Prevention;primary outcome;Procedures;Proctor framework;programs;Provider;Psyche structure;Psychiatrist;Psychologist;Publications;Publishing;Qualitative Methods;recruit;reinforced behavior;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;Scientist;Services;skills;Sleep Deprivation;smartphone application;Smoking;social;statistics;Structure;Telephone Interviews;Testing;therapy development;Time;Training;Unhealthy Diet;virtual;Work

PROJECT_TITLE: My Healthy Brain: a mindfulness-based lifestyle intervention to modify early risk of dementia in older adults

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE This project aims to develop teaching tools to enhance research rigor in the basic neurosciences. These materials will be used to improve the design and analysis of research projects carried out by undergraduates, graduate students, postdoctoral fellows and faculty. Thus, while they will have no direct impact on human health, they are a critical component for addressing the reproducibility crisis in the basic sciences and thereby improving the quality of the discoveries that feed the pipeline for translational and clinical therapies.

PI_NAMEs: BORN, RICHARD T (contact);TAN, TARALYN MARIE

PROGRAM_OFFICER_NAME: CRAWFORD, DEVON CHRISTINE

PROJECT_TERMS: Active Learning;Address;analysis pipeline;animation;Area;Awareness;Basic Science;Biological;Clinical;Code;Cognitive;combat;Communities;Comprehension;computational neuroscience;computerized data processing;Data;Data Analyses;design;Development;Doctor of Philosophy;Documentation;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Elements;Ensure;Exercise;experimental analysis;Experimental Designs;experimental study;Faculty;Failure;Fostering;Glossary;graduate student;Health;Human;improved;innovation;Instruction;instructor;interactive visualization;Interview;Knowledge;Learning;Mathematics;Methods;Mind;Morphologic artifacts;Names;Neurosciences;Neurosciences Research;Outcome;Output;pedagogical content;Postdoctoral Fellow;programs;Readability;Reading;Recording of previous events;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Sampling;Scientist;sound;Source;student participation;Students;System;Teaching Materials;Testing;Thinking;Time;tool;Training;Training Programs;translational pipeline;undergraduate student;Universities;Visualization;Writing

PROJECT_TITLE: Mind the Gap: Addressing "Missing Pieces" in Neuroscience Curricula to Reinforce Research Rigor


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative We will use advanced statistical methods to quantify the evidence of associations between ambient air pollution and AD/ADRD to better frame environmental policy. Leveraging national datasets capturing over 100 million Medicare beneficiaries, we will assess multiple types of air pollutants, including criteria air pollutants (PM2.5, NO2, and ozone) and various PM2.5 chemical components. This work will fill major gaps in the epidemiology of environmental exposures and AD/ADRD morbidity, which can inform policy for targeted source-specific regulations with the greatest health protection that can potentially mitigate the AD/ADRD health burden due to air pollution.

PI_NAMEs: STEENLAND, NELSON K (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Acceleration;Acidity;Address;Aerosols;Affect;Air Pollutants;Air Pollution;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease related dementia;ambient air pollution;Ammonia;Bayesian Method;beneficiary;Biological;Biological Availability;Caring;Cause of Death;Chemicals;Chronic;cognitive function;cohort;Coupled;criteria air pollutant;Data;Data Set;data warehouse;Databases;Dementia;dementia risk;Diagnosis;Disease;Economics;Elderly;Environmental Epidemiology;Environmental Exposure;Environmental Policy;Epidemiology;Event;Exposure to;fine particles;flexibility;Gases;Goals;Health;Health protection;high risk;Home Care Services;Hospitalization;human old age (65+);Impaired cognition;Incidence;Individual;Inpatients;Knowledge;Learning;Link;Liquid substance;Long-Term Effects;Longitudinal cohort;machine learning method;Measurement;Measures;Medicare;Medicare claim;Metals;Modeling;modifiable risk;Modification;Morbidity - disease rate;neuroinflammation;Nitrogen Dioxide;Noise;novel;Outcome;Outpatients;Oxidative Stress;Ozone;Pathogenesis;Pathway interactions;Patients;Persons;Phase;Play;Policies;Pollution;Positioning Attribute;prevent;Public Health;Publishing;Race;Records;Regulation;Reporting;Research;Resolution;response;Risk Factors;Role;Sensitivity and Specificity;sex;Skilled Nursing Facilities;social;Source;Statistical Methods;Survival Analysis;systemic inflammatory response;Thermodynamics;Time;Toxic effect;Toxicology;Trace metal;Uncertainty;United States;United States National Academy of Sciences;Update;Visit;Water;Work;World Health Organization

PROJECT_TITLE: Air Pollution and Alzheimer's Disease and Related Dementias: A National Study

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Aging;Cardiovascular;Estrogen;Genetics;Heart Disease;Human Genome;Women's Health Research

ORG_CITY: AUGUSTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Project Narrative  The proposed research is highly relevant to public health because sex hormones in women decline with aging while sex chromosomes alterations are unknown. Therefore, understanding how decline in estrogen impacts sex chromosomes in women is an important step towards improving health outcomes in menopausal women. Upon conclusion of this project, we will understand the interplay of sex hormones and chromosomes impact in vascular function which will identify novel targets for hormone therapy on the cardiovascular system.

PI_NAMEs: OGOLA, BENARD OJWANG (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Aging;Antioxidants;Aorta;arterial stiffness;Award;Bioinformatics;Biomechanics;Blood Pressure;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Physiology;Cardiovascular system;career development;cell type;Cells;Chromosome abnormality;Complement;Data;Development;Disease;Electron Spin Resonance Spectroscopy;Electrons;Ensure;Epigenetic Process;Equipment;Estrogen decline;Estrogens;Fellowship;Female;Flow Cytometry;Fluorescent in Situ Hybridization;Four Core Genotypes;Future;Gene Expression;Genes;Genetic;Genotype;Goals;Gonadal Hormones;Gonadal Steroid Hormones;Health;Hormonal;hormone therapy;Hormones;Hypertension;improved;in vivo;independency;Inflammation;Inherited;innovation;Knowledge;Length;Link;Maintenance;male;Maps;Mediating;Mediator;men;Menopause;Mentors;minority scientist;Mitochondria;Molecular;mouse model;Mus;Myography;novel;Outcome;Ovary;Oxidative Stress;Pathway interactions;Phase;Physiologic pulse;Ploidies;Postmenopause;Premenopause;preservation;pressure;prevent;programs;protective effect;Public Health;Publishing;Pulmonary Hypertension;Reactive Oxygen Species;Research;Resolution;RNA;Role;Science;sex;Sex Chromosomes;Sex Differences;sexual dimorphism;skills;Smooth Muscle Myocytes;Spectrum Analysis;Stroke;Structure;T-Lymphocyte;Techniques;Telemetry;Telomerase;telomere;Telomere Shortening;Testing;Testis;Tissues;Training;Transcript;transcriptome sequencing;ultrasound;Underrepresented Minority;Untranslated RNA;Woman;women versus men;X Chromosome;X Inactivation;XX male;Y Chromosome

PROJECT_TITLE: Interplay of Sex Hormones and Chromosomes in Vascular Oxidative Stress and Arterial Stiffening

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Women's Health Research

PHR: PROJECT NARRATIVE Sex and gender influences are an understudied feature of human health and disease. The genomic correlates of sex and gender and the connections of these genes in biological networks, may provide insights into pathways that influence progressive structural and functional changes across human systems; tools to perform this research have lagged. Investigating networks of sex differences in normal tissues, complex disease and cancers, and mining pathways for potential therapeutic interventions, may inform new diagnostics and strategies for sex and gender informed Precision Medicine.

PI_NAMEs: DEMEO, DAWN L (contact);QUACKENBUSH, JOHN

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Awareness;Biological;Brain;Chronic Obstructive Pulmonary Disease;Clinical;Colon;Complex;Computer software;Data;Development;Disease;disease model;Disease Progression;disorder risk;DNA Methylation;DNA Methylation Regulation;Dose;Ensure;Epigenetic Process;epigenetic regulation;Exhibits;Female;Future;Gender;gender difference;Gene Expression;Gene Expression Regulation;gene regulatory network;Generations;Genes;Genetic;genetic association;Genomics;Goals;Growth;Health;health difference;Heart;hormone regulation;Human;human disease;in silico;Individual;innovation;insight;life span;male;Malignant neoplasm of lung;Malignant Neoplasms;Maps;men;Methods;Methylation;Mining;Modeling;multiple data types;multiple omics;Nature;network models;Network-based;Noise;Normal tissue morphology;novel diagnostics;open data;Pathway interactions;Pattern;personalized therapeutic;precision medicine;Process;Relative Risks;Research;response;Risk;Scanning;screening;sex;Sex Chromosomes;Sex Differences;Signal Transduction;Smoking Behavior;Source Code;Structure;Structure of parenchyma of lung;System;Therapeutic;Therapeutic Intervention;therapeutic target;Time;Tissue Sample;Tissues;tool;treatment response;Variant;Woman;Women's Health;Work;X Chromosome;X Inactivation;Y Chromosome

PROJECT_TITLE: Networks Tools to Understand Sex- and Gender-Specific Drivers of Disease


ADMINISTERING_IC: MH

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Rehabilitation

ORG_CITY: SEATTLE

ORG_NAME: LYSSN.IO, INC.

ORG_STATE: WA

PHR: PROJECT NARRATIVE Evidence-based psychotherapies such as cognitive-behavioral therapy (CBT) are increasingly emphasized in professional practice guidelines, taught in training programs, sought out by consumers, and valued by payers. Yet, at present, there is no scalable method for evaluating CBT fidelity to support training, supervision, and quality assurance in community practice settings. The current study will develop and evaluate a clinical support software tool (LyssnCBT) that uses speech signal processing and machine learning to automate CBT fidelity and support high-quality CBT supervision and service delivery in community settings.

PI_NAMEs: ATKINS, DAVID CHARLES (contact);CREED, TORREY A.

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: addiction;Administrator;Adult;American;artificial intelligence algorithm;Behavioral;behavioral health;Client;Clinic;Clinical;Clinical Research;cloud based;cloud platform;Code;cognitive enhancement;Cognitive Therapy;Collaborations;commercialization;Communities;Community Practice;community setting;Complex;Computer software;Consumption;cost;cost efficient;Counseling;dashboard;Data;design;Development;digital tool;disability;Dropout;Educational process of instructing;Effectiveness;effectiveness evaluation;effectiveness-implementation randomized trial;effectiveness/implementation hybrid;Engineering;Evaluation;evidence base;Feedback;Focus Groups;Foundations;Future;Goals;Health Insurance Portability and Accountability Act;Health Technology;Healthcare Systems;Human;Implementation readiness;implementation science;improved;innovation;Institution;Interview;Investments;Machine Learning;Major Depressive Disorder;Mental disorders;Mental Health;Mental Health Services;Methodology;Methods;Monitor;motivational enhancement therapy;National Institute of Mental Health;Outcome;Patients;Performance;Persons;Phase;phase II trial;Pilot Projects;Policies;Practice Guidelines;practice setting;Professional Practice;Protocols documentation;prototype;Provider;Psychotherapy;Qualifying;quality assurance;Randomized;Readiness;Reporting;Research;Resources;scale up;Science;Secure;service delivery;Services;services as usual;signal processing;skills;Small Business Technology Transfer Research;software as a service;software development;software systems;Software Tools;Speech;speech processing;Standardization;Strategic Planning;Supervision;symptomatic improvement;System;Technology;technology development;telehealth;Testing;therapeutic development;Time;tool;Training;Training Programs;Training Support;Treatment outcome;Universities;usability;user centered design;Vision;web platform;Work

PROJECT_TITLE: Enhancing the quality of CBT in community mental health through AI-generated fidelity feedback


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Women's Health Research

ORG_CITY: SYRACUSE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE Dengue viruses (DENV) are the most significant arboviral cause of human death and disease, but vaccine development is challenged by our incomplete understanding of how lasting immunity to multiple DENV serotypes may be generated and how it may be identified in immunological assays. This study will leverage an established and uniquely long-term family cohort study for DENV in Thailand to define how the early immune environment to DENV, as shaped by maternally-transferred DENV antibodies and the timing and features of early DENV and non-DENV flavivirus exposures, shapes an individual’s future antibody-mediated immune profiles to DENV and subsequent risks of dengue illness. This proposed research is relevant for human health because it will identify features of exposure histories and pre-infection immunity associated with protection from dengue illness, ultimately supporting the identification of correlates of protection, which are critically needed for public health surveillance and countermeasure development.

PI_NAMEs: ANDERSON, KATHRYN B (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute;Address;Antibodies;Antibody titer measurement;Antigens;Arboviruses;Area;Benchmarking;Breast Feeding;Cessation of life;Child;Clinical;cohort;Cohort Studies;Communicable Diseases;cross reactivity;Custom;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Development;Diagnostic;Disease;efficacy trial;Enrollment;Environment;expectation;Exposure to;Family;Flavivirus;Funding;Future;Generations;Goals;Health;Household;Human;Humoral Immunities;Immune;Immunity;immunogenicity;Immunoglobulin G;Immunologics;Immunology procedure;Immunotherapy;Incidence;Individual;Infant;Infection;innovation;Japanese encephalitis virus;Kinetics;Knowledge;Locales;Longitudinal cohort study;Longterm Follow-up;Malaria;Maps;Maternally-Acquired Immunity;mathematical model;Mediating;Mission;Modeling;Mothers;National Institute of Allergy and Infectious Disease;Outcome;Pathogenesis;Phenotype;placental transfer;Population Surveillance;Pregnant Women;prenatal;prevent;primary outcome;protective effect;Recording of previous events;Research;Risk;Safety;Saliva;Sampling;secondary infection;seroconversion;Serotyping;severe dengue;Shapes;Specimen;Techniques;Testing;Thailand;Time;tool;Triage;United States National Institutes of Health;Vaccinated;Vaccination;vaccine development;Vaccine Therapy;Vaccines;viral transmission;Virus Diseases;ward;Zika Virus;ZIKV infection

PROJECT_TITLE: Defining correlates of protection from dengue illness in a long-term cohort study of multigenerational house-holds in Thailand

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-G(02)M]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Digestive Diseases - (Gallbladder);Health Services;Patient Safety;Prevention

ORG_CITY: Newark

ORG_DEPT: SURGERY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Despite Symptomatic Gallstone Disease being the most common digestive disorder requiring surgery in the US and evidence of perhaps 5 to 10x higher mortality for the population undergoing the emergency type of surgery treatment, we know very little about risk factors we could feasibly intervene on to ensure this prevalent US disease is addressed as much as possible without surgery or as a non-emergency procedure. We will use a policy intervention as a natural experiment to advance understanding of the natural history of gallstone disease mortality, including the frequency of, and mortality after, emergency versus non-emergency cholecystectomy. Ultimately, the goal of this line of research will be to decrease mortality from emergency surgery, either by reducing unnecessary cholecystectomy, or making sure necessary cholecystectomy is most commonly elective.

PI_NAMEs: PECK, GREGORY LANCE (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Abdomen;Address;Behavioral;Biological;Biometry;career;career development;Caring;Case Fatality Rates;Cessation of life;Cholecystectomy;Cholelithiasis;Clinical;clinical epidemiology;Clinical Investigator;Cognitive;Collaborations;cost;Data;Data Set;Data Sources;Death Rate;Decision Making;design;Development Plans;Diagnosis;Digestive System Disorders;disadvantaged background;Disease;Drainage procedure;Emergency Situation;Ensure;Environment;Epidemiologic Methods;Epidemiologist;Epidemiology;epidemiology study;Etiology;Excision;experience;Fostering;Foundations;Frequencies;Funding;Future;Gallbladder;gallstone disease;Goals;health care delivery;Health Insurance;Healthcare;high risk;Hospitalization;Hospitals;human old age (65+);Inpatients;insight;Insurance;Intervention;Intestines;Investigation;Liver;Medicaid;Medical;Mentors;Mentorship;Methods;Mission;mortality;mortality risk;National Institute of Diabetes and Digestive and Kidney Diseases;Natural experiment;Natural History;novel;operation;Operative Surgical Procedures;Outpatients;Pancreas;patient oriented research;Patients;Persons;Policies;Population;population based;Population Research;Population Study;Postoperative Complications;Prevalence;prevent;Prevention;Primary Prevention;Procedures;Process;programs;Public Health;Publishing;Qualitative Methods;Research;Research Personnel;Research Support;response;Risk;Risk Factors;Secondary Prevention;Selection Bias;Series;skills;social;Suggestion;Symptoms;Techniques;tertiary prevention;Testing;Training;trend;United States;Unnecessary Surgery

PROJECT_TITLE: The Natural History of Overall Mortality with Diagnosed Symptomatic Gallstone Disease in the United States: A Sequential Mixed-methods Study Evaluating Emergency, Non-emergency, and No Cholecystectomy

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Cancer patient navigation (PN) is an effective strategy for resolving patient barriers to care and improving completion and consistency of cancer screening, follow-up of abnormal findings, and treatment initiation. However, as the current standard one-on-one PN model is challenging to scale across cancers and economically difficult to sustain, we propose to convert one-on-one PN into a learning health system “PN 2.0 Checklist” that will help coordinate navigation workflow and integrate clinical team members with community/local resources. We will conduct a pragmatic, randomized trial to test whether this checklist strategy is as effective as one-on- one PN in addressing patients’ social determinants of health and recommended cancer-related screenings, behavioral counseling, and immunizations.

PI_NAMEs: SIMON, MELISSA A. (contact)

PROGRAM_OFFICER_NAME: BRICK, RACHELLE SOPHIA

PROJECT_TERMS: Accountability;Address;Adult;Advisory Committees;Area;barrier to care;Behavioral;cancer care;Cancer Patient;care delivery;Caring;Chicago;Chinese;Chinese American;Climate;Clinical;Collaborations;Communities;Community Clinical Oncology Program;Community Health;Community Participation;compare effectiveness;Consolidated Framework for Implementation Research;Cost Analysis;Counseling;design;Diagnostic;effectiveness/implementation trial;evidence base;follow-up;Funding;Health;Health system;Healthcare Systems;Hospitals;Human Papillomavirus;Hybrids;Immigrant;Immigrant community;Immunization;implementation evaluation;implementation strategy;implementation/effectiveness;improved;Institution;Intervention;Interview;Learning;Linguistics;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mammographic screening;Medical center;medically underserved;medically underserved population;member;Methods;Midwestern United States;Modeling;Organizational Change;Organizational Culture;organizational readiness;Participant;participant enrollment;patient navigation;patient-level barriers;Patients;payment;Population;post intervention;pragmatic trial;Preventive service;primary outcome;process evaluation;programs;prototype;Randomized;randomized trial;Recommendation;recruit;Research;Research Personnel;Resolution;Resources;safety net;screening;Screening for cancer;Screening procedure;secondary outcome;Service setting;Services;social;social health determinants;social service provider;Social Work;Surveys;System;Testing;Thinking;Time;Underserved Population;United States Preventative Services Task Force;Universities;Work

PROJECT_TITLE: Patient Navigation 2.0: Addressing the Challenge of Scaling Navigation through Checklist-based Implementation

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed research will address the biology of neural circuit formation in the retina and is relevant to public health for understanding both the biology of vision and the basic processes through which the nervous system organizes itself during development. Further, it will identify functional mechanisms for a family of molecules that are essential for normal neural development and that are mutated or dysregulated in disorders from dyslexia to schizophrenia. Identifying these mechanisms is a crucial step towards understanding these disorders and developing therapeutic strategies to treat them.

PI_NAMEs: GARRETT, ANDREW  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: adeno-associated viral vector;Alleles;Animal Testing;Bar Codes;Biology;Biotinylation;Cell Adhesion Molecules;Cell Death;Cell Survival;cell type;Cells;Central Nervous System;Complex;CRISPR/Cas technology;Dedications;Dendrites;Detection;Development;Discrimination;Disease;Dyslexia;Electrophysiology (science);Electroporation;Event;Exhibits;Failure;Family;Gene Cluster;Gene Delivery;Goals;in vivo;insight;interest;Learning;Maps;Mass Spectrum Analysis;Measurement;Mediating;Modeling;Molecular;Morphology;Motion;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Nervous System;neural circuit;Neurites;neurodevelopment;Neurodevelopmental Disorder;neuronal survival;Neurons;overexpression;patch clamp;Pathway interactions;Process;Protein Isoforms;Proteins;Proteomics;PTK2 gene;Public Health;Regulation;Research;Retina;Retinal Ganglion Cells;Role;Schizophrenia;Series;small hairpin RNA;Specificity;starburst amacrine cell;Synapses;Tertiary Protein Structure;Testing;Therapeutic;Vision;Visual;visual information

PROJECT_TITLE: Mechanisms of Cell Adhesion Molecule Function in Retinal Development

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE The proposed studies aim to understand how tissue resident macrophages maintain mammary gland tissue homeostasis during critical windows of development. Understanding these mechanisms will provide insight of how disrupted tissue homeostasis leads to disease, such as tumorigenesis.

PI_NAMEs: MACHADO, HEATHER L (contact);SCHWERTFEGER, KATHRYN L

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: Ablation;Adult;Alveolar;Anti-Inflammatory Agents;Automobile Driving;Bioinformatics;Breast Cancer Risk Factor;Cell Differentiation process;Collagen;conditional knockout;CSF1R gene;cytokine;Data;Deposition;Development;Diestrus;Disease;Duct (organ) structure;Ductal Epithelium;Epithelium;Equilibrium;Estrous Cycle;Event;Extracellular Matrix;Follow-Up Studies;Gene Expression Profile;Genetic;genetic approach;Genomic approach;Germ Lines;Goals;Health;Heterogeneity;Homeostasis;Hot Spot;Impairment;insight;Laboratories;Lactation;Macrophage;mammary;Mammary gland;mammary gland development;Mammary Gland Parenchyma;Mediating;Mus;Myeloid Cells;Neoplasm Metastasis;Nulliparity;Organ;Phenotype;Population;Population Analysis;postnatal development;Predisposition;Pregnancy;Publishing;Regulation;response;Role;single cell genomics;stem cell expansion;Structure;tissue repair;Tissues;transcription factor;Transplantation;tumor progression;tumorigenesis;uptake

PROJECT_TITLE: Functions of ductal- and stromal-associated macrophages in the mammary gland

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Familial hypertrophic cardiomyopathy (HCM) is a common genetic cardiomyopathy that leads to heart failure, but no specific disease-modifying therapy exists, even in cases with confirmed pathogenic variants. Breakthroughs in understanding of underlying mechanism are necessary to develop new therapies for treating HCM and new diagnostic tools to predict HCM risk and severity. In this proposal, I will use patient-derived induced pluripotent stem cells to interrogate mechanisms through which pathogenic myosin heavy chain-7 variants induce contractile dysfunction to increase our understanding of HCM’s pathogenesis and enable novel therapeutic and diagnostic approaches.

PI_NAMEs: LOIBEN, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Address;Adult;Affect;Alleles;Amino Acids;Benign;Biopsy;Blood;Cardiac;Cardiac Myocytes;Cardiac Myosins;cardiac tissue engineering;Cellular biology;Classification;Clinical;clinical application;ClinVar;collaborative environment;CRISPR/Cas technology;Data;Diagnosis;Diagnostic;diagnostic strategy;diagnostic tool;Disease;disease-causing mutation;economic impact;experimental study;Familial Hypertrophic Cardiomyopathy;Functional disorder;Genes;Genetic;Genetic Transcription;Goals;Heart;Heart failure;human induced pluripotent stem cells;Hypertrophic Cardiomyopathy;improved;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;inherited cardiomyopathy;Intervention;Laboratory Research;Lead;Left Ventricular Hypertrophy;Medicine;Mentorship;Methods;middle age;Modeling;mutant;Mutation;Myosin ATPase;Myosin Heavy Chains;myosin-binding protein C;novel;novel diagnostics;novel therapeutics;Outcome;overexpression;Pathogenesis;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Phenotype;Photobleaching;predictive tools;Protein Deficiency;Protein Isoforms;Proteins;Pump;rapid technique;Recovery;Reporting;restoration;Risk;Rodent Model;Role;Sarcomeres;Severities;Site;supportive environment;Testing;Therapeutic;Thick Filament;Tissue Engineering;Training;Universities;Variant;variant of unknown significance;Washington;Work;yeast two hybrid system

PROJECT_TITLE: Dissecting the mechanisms of how MYH7 S2 mutations lead to genetic hypertrophic cardiomyopathy


NIH_SPENDING_CATS: Bioengineering;Genetics;Health Effects of Indoor Air Pollution;Human Genome

ORG_CITY: PHILADELPHIA

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Allergic disease is very common and carries substantial public-health burdens. Genome-wide association studies estimate the heritability of allergy is high, suggesting that understanding the genetic liability underlying these conditions is key to understanding their etiology. Our overall objective is to determine the molecular processes through which genome topology contributes to allergic diseases.

PI_NAMEs: HENAO-MEJIA, JORGE ;VAHEDI, GOLNAZ  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;Allergens;Allergic;Allergic Disease;allergic response;Architecture;Asthma;Atopic Dermatitis;Bacteria;CD4 Positive T Lymphocytes;Cell Physiology;cell type;Cells;Chromatin;Competence;Complex;Control Locus;Data;Defect;Disease;Elements;Endowment;Engineering;eosinophil;Etiology;ETS1 gene;experimental study;FLI1 gene;Flow Cytometry;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Enhancer Element;Genetic Polymorphism;Genome;genome wide association study;Genomic Segment;Genomics;Goals;Heritability;Human;Human Genome;Hypersensitivity;Immune;Immune response;Immune System Diseases;in vivo;Investigation;Left;Link;Lung;Mediating;Modeling;Modification;Molecular;Mouse Strains;multiple omics;Mus;novel;Nuclear;Nucleotides;pathogen;Pathogenicity;Phenotype;Play;Population;Process;promoter;Public Health;Pyroglyphidae;Regulatory Element;response;risk variant;Role;Sequence Homologs;Single Nucleotide Polymorphism;Structure;Structure of parenchyma of lung;superresolution microscopy;T cell differentiation;T-Cell Development;T-Lymphocyte;Testing;Th2 Cells;Untranslated RNA;Variant;Work

PROJECT_TITLE: 3D genome organization of the Ets1-Fli1 locus controls allergic responses

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The Healthy Brain and Child Development National Consortium study (HBCD) will follow 7,500 mothers and their children from locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation. The proposed HBCD National Consortium Administrative Core (HCAC) will provide the leadership and overall management of the consortium to ensure the project’s success.

PI_NAMEs: CHAMBERS, CHRISTINA  (contact);NELSON, CHARLES ALEXANDER

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Accountability;Address;Adult women;Affect;Alcohols;Behavioral;Bioinformatics;Biological;Biological Factors;Birth;Brain;brain health;Child;Child Development;Childhood;cohort;Cohort Studies;Collaborations;Collection;Communication;Communities;Complex;Consultations;critical period;Data;Data Collection;Data Coordinating Center;data harmonization;Data Set;Decision Making;design;Development;DNA;early experience;Electroencephalography;Electronic Health Record;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Hazards;Environmental Risk Factor;Epidemiology;equity, diversity, and inclusion;Ethics;Ethnic Origin;experience;Exposure to;fetal substance exposure;Genes;Goals;hazard;Health;health disparity;Helping to End Addiction Long-term;high risk;improved;infancy;Infant;innovation;Intervention;Leadership;Legal;Life;Link;Location;longitudinal dataset;Magnetic Resonance Imaging;maltreatment;Maps;Marijuana;Maternal Health;Measures;meetings;Modality;Modification;Monitor;Mothers;multidimensional data;neurobehavioral;neurodevelopment;neuroimaging;neurophysiology;Opiate Addiction;Opioid;opioid misuse;Participant;Performance;performance site;Personal Satisfaction;Persons;physical conditioning;Physiological;Policies;Population;postnatal;Pregnancy;Pregnant Women;prenatal;prenatal exposure;Process;prospective;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Publications;Questionnaires;Race;recruit;Reproducibility;Research;Research Design;Research Personnel;resilience;Resource Sharing;Sampling;Shapes;Site;socioeconomics;Speed;Standardization;stem;Stress;Structural Racism;substance use;success;Technology;Tobacco;tool;Toxicant exposure;Training;training opportunity;United States National Institutes of Health;Vulnerable Populations;wearable sensor technology;web site;Woman;Work

PROJECT_TITLE: The Healthy Brain and Child Development National Consortium Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-Z(51)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: NARRATIVE Screening for lung cancer has the potential for a profound public health benefit. Repeat annual screening is necessary for early detection of lung cancer. We will test two interventions which include patient education and reminders to improve adherence to lung cancer screening.

PI_NAMEs: WERNLI, KAREN J (contact)

PROGRAM_OFFICER_NAME: SARMA, ELIZABETH ANNE

PROJECT_TERMS: Address;Adherence;adherence rate;Adult;American;arm;Caring;Cessation of life;Clinic;Clinical;Clinical Trials;Cluster randomized trial;Colorectal Cancer;compare effectiveness;design;Education;Educational workshop;Electronic Health Record;Eligibility Determination;Ensure;evidence base;experience;follow-up;four-arm study;Fright;Goals;Guidelines;Health;Health Benefit;health care settings;health management;Health system;Healthcare Systems;high risk;human centered design;implementation barriers;implementation facilitators;implementation intervention;improved;International;Intervention;Knowledge;loved ones;low dose computed tomography;Lung;lung cancer screening;Lung nodule;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;member;men;Methods;Modification;Monitor;Morbidity - disease rate;mortality;Nodule;novel;Outcome;Participant;Patient Education;patient oriented;patient population;patient portal;Patient-Focused Outcomes;Patients;Perception;Pilot Projects;Population;population based;population health;primary care clinic;Public Health;Quality of Care;Randomized;randomized, clinical trials;Recommendation;Reporting;Research Design;Role;routine screening;Scanning;Schedule;screening;Screening for cancer;screening guidelines;screening program;shared decision making;Smoking;social stigma;System;Testing;Time;treatment as usual;trial enrollment;tv watching;United States Preventative Services Task Force;virtual healthcare;Voice;Washington;Woman

PROJECT_TITLE: Multilevel Interventions to Increase Adherence to Lung Cancer Screening

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]