NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Contraception/Reproduction;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Infertility;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE African-American women have strikingly high rates of cardiovascular disease (CVD) morbidity and mortality, and this is especially true at midlife. Theoretical and non-human primate models suggest that social stressors and ovarian aging may play a role, and the science proposed in this application is designed to examine these associations in a cohort of African-American women. The mentoring and training proposed in this application is designed to foster a supportive environment for the careers of junior patient-oriented researchers interested in social exposures and CVD risk in vulnerable groups of women.

PI_NAMEs: LEWIS, TENÉ T (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Acceleration;African American;African American Women;Age;aged;Aging;Animal Model;Antral;Automobile Driving;Award;Biological Assay;Biological Markers;black/white disparity;Blood specimen;Body mass index;Cardiology;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;career;Chronology;cohort;Collaborations;Consultations;Data;design;Development;diminished ovarian reserve;Discipline;Discrimination;Disease;Doctor of Philosophy;Education;Educational workshop;Emotional;Epidemiology;Estrogens;ethnic minority;Exposure to;Family;Fellowship Program;Female;Financial Hardship;Follicle Stimulating Hormone;Fostering;Friends;Funding;Future;Genetic;Goals;Grant;Health;health inequalities;Health Services Accessibility;Hormones;interest;intima media;Knowledge;Link;Master of Public Health;Measures;medical schools;men;Menopause;Menstrual cycle;Mentors;Meta-Analysis;Midcareer Investigator Award in Patient-Oriented Research;middle age;Midlife women;minority scientist;Modeling;Morbidity - disease rate;mortality;mullerian-inhibiting hormone;multidisciplinary;multimodality;National Heart, Lung, and Blood Institute;nonhuman primate;Outcome;Ovarian;Ovarian aging;ovarian reserve;Parents;patient oriented;patient oriented research;Physiologic pulse;Physiological;Pilot Projects;Populations at Risk;Premature Menopause;Premenopause;Process;programs;prospective;Public Health Schools;racial minority;Records;Reporting;reproductive;Research;Research Personnel;Risk Factors;Science;skills;Smoking;social;social stress;social stressor;sociodemographics;Socioeconomic Status;stress management;Study of Women's Health Across the Nation;Subgroup;supportive environment;System;therapy design;Time;Training;Training Programs;ultrasound;Underrepresented Populations;Universities;Vulnerable Populations;White Women;Woman;Women's Group;Women's Health

PROJECT_TITLE: Mentoring and Patient-Oriented Research on Social Exposures and CVD Risk in Underrepresented Women

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The human brain undergoes rapid changes in early childhood development. This project will develop new experimental and data processing tools to track brain chemistry during this important period, using an MRI scanner.

PI_NAMEs: EDDEN, RICHARD ANTHONY EDWARD (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TITLE: Edited Magnetic Resonance Spectroscopy of the Pediatric Brain

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Human Genome;Precision Medicine;Prevention

ORG_CITY: PORTLAND

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Despite advances in screening, colorectal cancer remains a leading cause of cancer-related death due to a high recurrence rate after initial treatment and a dismal 14.3% survival rate of patients with recurrent disease. Improving survival from colorectal cancer requires the ability to develop effective biomarkers for early detection of recurrent/pre-metastatic disease. We leverage computational approaches to integrate imaging and –omics analyses to establish and validate a non-invasive biomarker for risk of metastases.

PI_NAMEs: CHANG, YOUNG HWAN ;WONG, MELISSA H. (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Advanced Development;Age;American Cancer Society;Biological;Biological Markers;Biological Process;biomarker development;biomarker panel;biomarker validation;cancer cell;Cancer Etiology;cancer imaging;Cell fusion;Cell Physiology;Cells;cellular imaging;Cessation of life;Characteristics;Chemotaxis;cohort;colon cancer patients;Colorectal Cancer;Computational Biology;Data;deep learning;Detection;detection assay;Development;Diagnosis;Disease;early detection biomarkers;Early Diagnosis;experience;Foundations;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;genomic signature;Genomics;Genotype;Goals;Heterogeneity;high dimensionality;Hybrid Cells;Hybrids;Image;Image Enhancement;imaging approach;imaging biomarker;imaging modality;improved;Individual;Inflammation;insight;lifetime risk;Ligands;liquid biopsy;Macrophage;macrophage product;Measures;metastatic colorectal;migration;Modality;Molecular;multidisciplinary;multimodality;multiplexed imaging;Names;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Newly Diagnosed;novel;Operative Surgical Procedures;Pathway interactions;Patient risk;Patients;peripheral blood;Phenotype;Population;predictive modeling;Primary Neoplasm;Prognosis;prognostic;Proliferating;Property;protein expression;receptor;Recurrence;Recurrent disease;response;Risk;Sample Size;Sampling;screening;screening guidelines;Sensitivity and Specificity;sensor;Side;single cell analysis;single-cell RNA sequencing;Site;Specificity;Specimen;Survival Rate;System;Technology;Testing;Time;treatment response;tumor;tumor growth;tumor initiation;Tumor Markers;Validation

PROJECT_TITLE: Integrative single cell analyses of inflammation-derived circulating hybrid cells to identify aggressive disease


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Lymphatic Research;Patient Safety;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  Subjective clinical assessments of patient risk in HPV-associated oropharyngeal squamous cell carcinoma (OPC) could be improved with our novel objective liquid biopsy assay of the inflammatory fluid that collects in Jackson Pratt surgical drains. We believe we can use this proximal liquid analyte to sensitively detect tumor-shed cell-free HPV (cf-HPV) and comprehensively characterize tumor homing effector immune cells. We predict the integration of surgical drain fluid cf-HPV analysis with leukocyte immunophenotyping will predict patient pathological risk and patterns of recurrence, and could eventually be used to prospectively select candidates for treatment de-intensification clinical trials.

PI_NAMEs: EARLAND, NOAH JACKSON (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Adjuvant;Adjuvant Therapy;Aftercare;Alcohols;anti-tumor immune response;Benchmarking;Biological Assay;Biological Markers;Biopsy;cancer cell;cancer surgery;candidate selection;CD8-Positive T-Lymphocytes;cell free DNA;Cells;Cervical;chemoradiation;Cisplatin;Clinical;Clinical assessments;clinical diagnostics;Clinical Trials;Code;comorbidity;Cytometry;Data;Decision Making;Detection;digital;Disease;DNA;DNA analysis;Dose;Effector Cell;Ensure;Environment;Equation;Excision;exome sequencing;Extranodal;Future;Gene Expression;Gene Frequency;genetic variant;Goals;high risk;Homing;Hour;HPV negative;HPV positive;HPV-High Risk;HPV-negative head and neck cancer;human papilloma virus oropharyngeal squamous cell carcinoma;Human Papillomavirus;Image;Immune;Immune Response Genes;Immunophenotyping;improved;Incidence;Individual;Infiltration;Inflammatory;Kinetics;Laceration;Length;leukocyte activation;Leukocytes;liquid biopsy;Liquid substance;Lymph;lymph nodes;Lymphatic System;Malignant Neoplasms;malignant oropharynx neoplasm;Measures;Metastatic Neoplasm to Lymph Nodes;Micrometastasis;minimally invasive;Molecular;Morbidity - disease rate;mutant;Mutation;Neck Dissection;neoplastic cell;next generation sequencing;Nodal;novel;Operative Surgical Procedures;Oropharyngeal Squamous Cell Carcinoma;Pathologic;Pathology;Patient risk;patient stratification;Patient-Focused Outcomes;Patients;Pattern;Plasma;Population;Postoperative Period;Primary Neoplasm;prognostic;prospective;Proxy;Quality of life;Radiation Dose Unit;Recurrence;Recurrent disease;Regimen;relapse prediction;Residual Neoplasm;Risk;Risk Assessment;Risk Marker;risk stratification;Saliva;salivary assay;Sampling;side effect;Signal Transduction;Site;success;Surgical Pathology;Survival Rate;Tobacco;tool;trafficking;Treatment outcome;treatment response;Treatment-related toxicity;tumor;tumor DNA;tumor microenvironment;Tumor stage;tumor-immune system interactions;Urine;Variant;wound bed

PROJECT_TITLE: A Novel Postoperative Prognostic Liquid Biopsy: Tumor-Associated cfDNA and Leukocyte Analysis in Oropharyngeal Cancer Surgical Drain Fluid


ADMINISTERING_IC: AI

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Alphavirus infection causes a robust innate immune response in host cells, including global protein translation shutoff, to reduce viral replication and prevent spread. However, alphaviruses have evolved unclear mechanisms to continue effective viral protein synthesis under conditions of translation shutoff. This proposal seeks to identify the mechanism by which alphaviruses initiate translation and modulate the host translational shutoff response with the goal of identifying novel targets for antivirals.

PI_NAMEs: DINNON, KENNETH HAROLD (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: 2019-nCoV;Ablation;Acute;Alpha Virus;Alphavirus Infections;Amino Acid Substitution;Amino Acids;Anti-viral Agents;Arsenites;arthropod-borne;Attenuated;Binding;Binding Proteins;biological adaptation to stress;Biological Models;Biology;Cells;chikungunya;Chimeric Proteins;Code;Complex;COVID-19 pandemic;Defect;density;Development;Disease Outbreaks;DNA-Directed RNA Polymerase;Double-Stranded RNA;Drug Targeting;Drug usage;druggable target;Eastern Equine Encephalitis Virus;Excision;FDA approved;Fever;forest;G3BP1 gene;gene therapy;Genetic Transcription;Goals;Homeostasis;Human;In Vitro;Infection;Innate Immune Response;insight;interest;Internal Ribosome Entry Site;Knowledge;Learning;Mass Spectrum Analysis;Measures;Mediating;medical countermeasure;Messenger RNA;Methods;mutant;Mutation;mutation screening;Neurologic;next generation;Nonstructural Protein;novel;novel therapeutic intervention;Organelles;pandemic pathogen;pathogen;pathogens of pandemic potential;Peptide Initiation Factors;Phosphorylation;Poly A;Poly(A)-Binding Proteins;pre-pandemic;prevent;Prokaryotic Initiation Factor-2;Protease Inhibitor;Protein Biosynthesis;protein kinase R;Proteins;reconstitution;recruit;Replication-Associated Process;Replicon;Repression;Research;Resistance;response;Reticulocytes;Reverse engineering;Ribosomes;RNA;Role;scaffold;Semliki forest virus;side effect;Sindbis Virus;Stress;stress granule;stress reduction;stressor;Structural Protein;Sucrose;System;targeted treatment;Testing;Therapeutic;Transfection;Translating;Translation Initiation;Translations;Vaccines;vector;vector vaccine;Viral;Viral Nonstructural Proteins;Viral Proteins;Viral Structural Proteins;viral transmission;Virus;Virus Replication;Work

PROJECT_TITLE: Elucidating the mechanisms of alphavirus subgenomic RNA translation


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Studies of fundamental cell death mechanisms provide unique opportunities for molecularly designed cancer therapeutics. The BCL-2 family proteins are central regulators of cell death and validated anti-cancer targets. We propose to investigate the molecular mechanisms by which BCL-2 family proteins regulate cell death with the hope that our study will enable novel targeted therapeutic strategies that specifically trigger cell death in cancer cells.

PI_NAMEs: CHENG, EMILY H (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: adaptive immunity;Affect;Affinity Chromatography;anti-cancer;Antineoplastic Agents;APAF1 gene;Apoptosis;Apoptotic;Applications Grants;BAX gene;BCL1 Oncogene;BCL2L1 gene;Biochemical;Bypass;calreticulin;cancer cell;cancer immunotherapy;cancer therapy;cancer type;Caspase;Caspase Inhibitor;Cell Death;Cell Membrane Permeability;Cells;Cessation of life;Clinic;Combined Modality Therapy;completed suicide;Complex;Cross-Priming;Cues;cytochrome c;Cytosol;Data;Defect;Dendritic cell activation;Dendritic Cells;design;Development;Disease;Doxorubicin;Drug Targeting;Engineering;Family;FDA approved;Foundations;Gel Chromatography;HMGB1 gene;Human;Immune;immune checkpoint blockade;Immune response;immunogenic cell death;Immunologic Memory;Immunologics;Immunotherapy;improved;In Vitro;in vivo;Inflammation Mediators;Inflammatory;Inflammatory Response;Injections;Inner mitochondrial membrane;innovation;insight;Interferon Type I;Malignant Neoplasms;Mass Spectrum Analysis;MCL1 gene;Mediating;Melanoma;Melanoma Cell;member;Mitochondria;Mitochondrial DNA;Molecular;Mus;mutant;Mutate;new therapeutic target;novel;Outer Mitochondrial Membrane;Pathway interactions;Permeability;Physiological;Play;preservation;prevent;Probability;Process;programs;prohibitin;Protein Family;protein protein interaction;Proteins;Proteomics;recruit;Reporting;Research;response;Role;Sentinel;Signal Transduction;Site;SLC25A4 gene;Stimulator of Interferon Genes;System;Testing;Therapeutic;Translating;tumor;Tumor Immunity;VDAC1 gene;VDAC2 gene

PROJECT_TITLE: Characterizing and Targeting BAX- and BAK-Dependent Cell Death in Cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Microbiome;Nutrition

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative: The human gut microbiome plays an important role in human health by producing drug-like small molecules. Despite the importance of microbial metabolism to human health and disease, little is known about the metabolic strategies that underlie production of drug-like small molecules by the gut microbiota. This project will define the pathways microbes in the gut use to make these molecules and develop new tools to study the metabolism of genetically intractable gut bacteria.

PI_NAMEs: DODD, DYLAN  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Acids;Amines;Bacteria;bacterial genetics;bacterial metabolism;Bacterial Physiology;Butyrates;Chromosome Mapping;commensal bacteria;dietary;Disease;drug production;Future;Genetic;Genetic Determinism;genome-wide;Growth;gut bacteria;gut microbiome;gut microbiota;Health;Human;Indoles;insight;Knowledge;Light;Link;Metabolic;metabolic abnormality assessment;Metabolic Control;Metabolic Pathway;Metabolism;metabolomics;Microbe;microbial;microbiome;Nature;Nutrient;Nutritional Requirements;Output;Pathway interactions;Pharmaceutical Preparations;Physiology;Play;Process;Role;Secure;small molecule;Techniques;tool;Volatile Fatty Acids

PROJECT_TITLE: Physiology of bacterial metabolism in the human gut microbiome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Infectious Diseases;Liver Disease;Pediatric;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ENTEBBE

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: UGANDA VIRUS RESEARCH INSTITUTE

ORG_ZIPCODE: EBB

PHR: NARRATIVE Intestinal schistosomiasis is a disease caused predominantly by Schistosoma mansoni and capable of causing notable sequelae including severe liver fibrosis, portal hypertension and often-fatal oesophageal bleeding. Its impact is most severe in poor, often hard-to-reach, communities in sub-Saharan Africa. The Uganda Schistosomiasis Multidisciplinary Research Center brings together international partners to build expertise and understanding of the underlying determinants of severe schistosomal morbidity, addressing each stage of the parasite’s life cycle; and to develop an integrated model for identifying appropriate interventions for prevention and management of this important disease.

PI_NAMEs: ELLIOTT, ALISON  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Address;Adult;Affect;Aflatoxins;Africa;Africa South of the Sahara;African;Antigens;Biological;biological specimen archives;Biomphalaria;career;case finding;Case/Control Studies;Child;Chronic;Clinical;co-infection;cohort;Collection;Communities;community empowerment;Complement;Data;Detection;Development;differential expression;disability-adjusted life years;Disease;DNA;doctoral student;Ecosystem;Educational workshop;Enrollment;Environment;Epidemiology;Esophagus;Evolution;exposed human population;Fostering;Foundations;Frequencies;Fresh Water;Future;Genetic;genetic variant;geographic difference;Goals;Health;Helminths;Hemorrhage;Hepatitis B;High Prevalence;Human;Human Activities;Immune response;immunogenic;immunoregulation;Infection;infection rate;infection risk;Interdisciplinary Study;International;Intervention;Intestines;Investigation;Investments;Joints;Leadership;Life;Life Cycle Stages;Life Style;Liver Fibrosis;Location;Malaria;Mentors;microbiome;Modeling;Morbidity - disease rate;mortality;neglected tropical diseases;next generation;Nursery Schools;nutrition;Nutritional;Outcome;Parasites;Pathogenesis;Persons;Pharmaceutical Preparations;Policies;Population;Population Genetics;Portal Hypertension;Praziquantel;Predisposition;Prevalence;Prevention;Prevention strategy;preventive intervention;programs;Research;Research Design;Research Personnel;Residual state;response;Risk;Risk Factors;Sampling;Schistosoma;Schistosoma mansoni;Schistosoma mansonii infection;Schistosome Parasite;Schistosomiasis;School-Age Population;Scientist;Seminal;Severity of illness;Site;Snails;Solid;stool sample;Surveys;Translations;transmission process;Tropical Medicine;Uganda;Variant;vector control

PROJECT_TITLE: Uganda Schistosomiasis Multidisciplinary Research Centre (U-SMRC)


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Contraception/Reproduction;Genetics;Infertility;Pediatric;Women's Health Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative  In species with distinct sexes, gonad development is informed by the activity of autosomal, and in some cases sex chromosome-associated, gene products. Even in organisms in which sex is determined by inheritance of sex chromosomes, disruptions of autosomal-regulated mechanisms and environmental influences can be detrimental to sexual development and negatively impact reproductive health. Thus, understanding the pathways regulating sexual development has important implications for reproductive development, health, and fertility.

PI_NAMEs: WILSON, MIRANDA  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Adult;Affect;Affinity Chromatography;autosome;Binding Sites;Biological Assay;Characteristics;Chromosome 4;Chromosomes;Cloning;Complex;Cytosine;Data;Dedications;detection of nutrient;Development;Developmental Biology;Disproportionately impacts women;DNA;DNA Methylation;Drosophila genus;Embryonic Development;Environmental Risk Factor;Etiology;Event;Failure;Female;Fertility;Fertility Disorders;Fostering;FRAP1 gene;gender dysphoria;gene conservation;Gene Expression;gene product;Generations;Genes;Genetic;genetic approach;Genomics;Germ cell tumor;gonad development;Gonadal Dysgenesis;Gonadal structure;Health;Hormonal;hormonal signals;Human;Impairment;Individual;Infertility;insight;Laboratories;Life;Link;Maintenance;male;Malignant Neoplasms;Mammals;Messenger RNA;Methylation;methylation pattern;Methyltransferase;Microscopy;Modeling;Molecular;mutant;Mutation;Nutrient availability;nutrition;Oocytes;Oogenesis;Organism;ovarian failure;Ovary;Pathway interactions;Phenotype;Polycystic Ovary Syndrome;posttranscriptional;Premature Ovarian Failure;preservation;programs;Proteins;Puberty;Regulation;Reiterated Genes;Reporter;Repression;Reproductive Biology;reproductive development;reproductive fitness;Reproductive Health;Research Personnel;Ribosomal DNA;Ribosomes;RNA;RNA Binding;RNA Splicing;RNA-Binding Proteins;Role;sex;Sex Chromosomes;sex determination;sex development disorder;Sex Differentiation;Sexual Development;Signal Transduction;Spermatogenesis;System;Testing;Testis;Training;Transcript;Transgenic Organisms;translation factor;Translations;Validation;Vertebrates;Virilism;Y Chromosome;Zebrafish

PROJECT_TITLE: Molecular mechanisms of sex-specific differentiation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-L(20)L]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Despite the clinical success of PD-1 blockade in treating multiple cancer types by alleviating suppression of anti- tumor T cell responses, the majority of cancer patients do not achieve durable remission. The proposed research will investigate metabolic pathways involved in the regulation of anti-tumor T cell function and responsiveness to PD-1 blockade. The goals of our studies are to identify the metabolic requirements of effective anti-tumor immunity and to define novel metabolic intervention strategies that may synergize with PD-1 blockade.

PI_NAMEs: GEORGIEV, PETER  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Acceleration;Adoptive Transfer;anti-PD-1;anti-PD1 therapy;asparaginase;Asparagine;Aspartate;Aspartate-Ammonia Ligase;Biological Response Modifiers;Blocking Antibodies;cancer clinical trial;Cancer Patient;cancer type;Carbon;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Cellular Immunology;Chronic;Clinical;Coculture Techniques;combinatorial;Combined Modality Therapy;CRISPR screen;CRISPR/Cas technology;cytotoxic;Cytotoxic T-Lymphocytes;Development;Disease remission;Dissociation;Enzymes;exhaust;exhaustion;experimental study;extracellular;functional genomics;Genes;Glutamine;Goals;immune activation;immune checkpoint;immune checkpoint blockade;Immune Evasion;Immune system;Immune Tolerance;Immunity;Immunologic Receptors;Immunologics;immunopathology;Impairment;improved;In Vitro;in vivo;Infusion procedures;Intervention;Isotope Labeling;Knowledge;Label;Ligands;Link;loss of function;Lymphocyte;Maintenance;Mediating;Metabolic;Metabolic Pathway;Metabolism;Monoclonal Antibodies;Mus;neoplastic cell;Nitrogen;novel;novel strategies;Nutrient;pathogen;Pathway interactions;patient subsets;Patients;Peripheral;pharmacologic;Play;progenitor;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;Property;Protein Biosynthesis;Proteins;Regulation;Research;Resistance;Resistance development;response;Role;stem;success;Supplementation;synergism;System;T cell response;T-Cell Activation;T-Lymphocyte;Techniques;Testing;Therapeutic;Translating;tumor;tumor growth;Tumor Immunity;tumor microenvironment;uptake;Validation

PROJECT_TITLE: Metabolic regulation of the anti-tumor CD8+ T cell response to PD-1 by asparagine


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Palliative Care;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: HOSPITAL FOR SICK CHLDRN (TORONTO)

ORG_STATE: ON

ORG_ZIPCODE: M5G 1X8

PHR: PROJECT NARRATIVE  Most children with cancer survive because they are given intensive treatments, but unfortunately, these treatments are associated with distressing symptoms. To address this problem, we developed the Symptom Screening in Pediatrics Tool (SSPedi) so that children receiving cancer treatments can communicate their bothersome symptoms, and Supportive care Prioritization, Assessment and Recommendations for Kids (SPARK), a web-based application that links identified symptoms to supportive care guidelines for symptom management. To establish that these tools improve the lives of children newly diagnosed with cancer, we will conduct a trial that randomizes 20 pediatric cancer institutions and measures the impact of three times weekly symptom screening, symptom feedback to healthcare providers and the development of care pathways for symptom management to improve total symptom burden, fatigue and quality of life.

PI_NAMEs: DUPUIS, LAURA LEE;GRIMES, ALLISON ;SUNG, LILLIAN  (contact)

PROGRAM_OFFICER_NAME: SMITH, ASHLEY

PROJECT_TERMS: 18 year old;Acute;Address;Adherence;Adolescent;Adoption;Adult;Area;cancer diagnosis;Cancer Patient;cancer survival;cancer therapy;care delivery;Caring;Characteristics;Child;Child health care;Clinic Visits;Clinical;clinical care;Clinical Practice Guideline;Cluster randomized trial;Collection;Communication;Control Groups;Cross-Sectional Studies;Development;Distress;Documentation;Effectiveness of Interventions;Elements;Emergency department visit;Enrollment;experience;Fatigue;Feedback;Future;group intervention;Guidelines;health care service utilization;Health Personnel;health record;Hospitalization;implementation process;improved;improved outcome;Inpatients;Institution;Intervention;intervention effect;Linear Regressions;Link;Malignant Childhood Neoplasm;Malignant Neoplasms;Managed Care;Measures;Medical Care Team;Modeling;Newly Diagnosed;Nurses;Outcome;Pain;participant enrollment;Pathway interactions;Patient Outcomes Assessments;Patient Representative;Patient Self-Report;Patients;Pediatrics;Physicians;Pilot Projects;Primary Health Care;primary outcome;provider adherence;Quality of Care;Quality of life;Questionnaires;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;reduce symptoms;Reporting;screening;Screening procedure;Site;Spanish;Supportive care;Symptom Burden;symptom management;symptomatic improvement;Symptoms;tool;treatment as usual;treatment duration;virtual;Visit;web app

PROJECT_TITLE: Symptom Screening Linked to Care Pathways for Children with Cancer: a Cluster Randomized Trial

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative CRISPR-Cas9 systems are frequently found in pathogenic bacteria, where they defend against phages but also prevent the horizontal transfer of antibiotic resistance genes and toxins. Here, we explore novel functions of Cas9 as a non-canonical transcriptional regulator, which could contribute to bacterial pathophysiology and inform new generations of regulatable Cas9 tools for the treatment of genetic diseases. We also study the heterogeneity of CRISPR-Cas immunity in single cells, which will have implications for the survival of human pathogens under stress and their treatment with phage therapies.

PI_NAMEs: MODELL, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: adaptive immunity;Antibiotic Resistance;Autoimmunity;Bacteria;Bacterial Chromosomes;Bacterial Genes;Bacteriophages;Biology;Cells;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;commensal bacteria;CRISPR/Cas technology;Development;drug resistant pathogen;Environment;Equilibrium;Event;Foundations;Functional disorder;gene editing technology;Generations;Genetic;Genetic Diseases;genetic element;Genetic Transcription;Guide RNA;Heterogeneity;Horizontal Gene Transfer;human pathogen;imaging platform;Immunity;Immunization;Infection;innovation;insight;Laboratory Study;Memory;novel;nuclease;pathogenic bacteria;Physiology;Plasmids;Population;prevent;promoter;Regulation;Repression;Research Design;resistance gene;Role;Route;spatiotemporal;Streptococcus pyogenes;Stress;System;Technology;Time;tool;Toxin;Transcription Repressor

PROJECT_TITLE: Non-canonical functions of Cas9 andthe cell biology of CRISPR-Cas immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Estrogen;Hearing Loss;Neurosciences;Regenerative Medicine;Women's Health Research

ORG_CITY: IOWA CITY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Moderate noise that does not necessarily affect audiometric thresholds can nevertheless cause significant hearing impairments by damaging cochlear synapses. We have found that female mice are overall less susceptible to such damage but female susceptibility varies through the estrous cycle with lowest susceptibility when progesterone levels are highest. In addition to progesterone, we have identified other treatments that promote regeneration of the synapses after noise exposure in mice that are potential therapeutic targets for this type of hearing impairment in humans.

PI_NAMEs: GREEN, STEVEN H (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Affect;Apical;Auditory;Auditory Brainstem Responses;Auditory Threshold;Brain;Cell membrane;Cell Nucleus;Cells;Ciliary Neurotrophic Factor;Cochlea;cochlear synaptopathy;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cytoplasm;Data;Enzyme Inhibition;Estrogens;Estrous Cycle;Estrus;excitotoxicity;experimental study;Exposure to;Female;follow-up;Future;Gene Expression;Genetic Transcription;Genomics;Glutamate Receptor;Gonadal Steroid Hormones;Hair Cells;hearing impairment;Histologic;Hormones;Human;In Vitro;in vitro Model;in vitro regeneration;in vivo;Inner Hair Cells;Longitudinal Studies;male;Mediating;Membrane;Mifepristone;Molecular;Mus;Natural regeneration;neuronal survival;Neurons;neurotrophic factor;Noise;noise exposure;non-genomic;novel therapeutic intervention;Nuclear;Nuclear Receptors;Ovariectomy;Peptides;Performance;Permeability;Phase;Phenotype;phosphodiesterase IV;Predisposition;prevent;Progesterone;Progesterone Receptors;protein function;Protein Inhibition;Protein Kinase;Reagent;receptor;Regenerative capacity;regenerative therapy;restoration;Role;Rolipram;Sensory;Sex Differences;Signal Pathway;Signal Transduction;small molecule therapeutics;sound;speech in noise;spiral ganglion;Synapses;Testing;therapeutic candidate;therapeutic target;Time;Tinnitus;tool;Transcript;transcriptome;Trauma

PROJECT_TITLE: Protection and restoration of cochlear synapses from noise-induced synaptopathy in male and female mice

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse;Women's Health Research

ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative Frequent binge alcohol drinking is a significant risk factor for developing an alcohol use disorder (AUD). Understanding how excessive alcohol use engages the brain is critical for discovering potential treatments, however, it is not known how alcohol differentially impacts the brains of males and females. This project uses a mouse model to investigate how the nucleus accumbens core impacts ethanol reward and binge-like drinking in both males and females.

PI_NAMEs: CHAN, AMY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Abstinence;Address;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol effect;alcohol response;alcohol reward;alcohol use disorder;Alcoholic Intoxication;Alcohols;Amygdaloid structure;Anatomy;Anesthesia procedures;Behavior;Bilateral;Biological Assay;Biological Markers;Blood;Blood specimen;Brain;Brain imaging;Brain region;Clozapine;conditioned place preference;conditioning;Cues;Darkness;Deep Brain Stimulation;Dendritic Spines;density;designer receptors exclusively activated by designer drugs;Diagnosis;Dose;drinking;drug of abuse;Ethanol;experimental group;Female;FOS gene;Genetic;genetic manipulation;Genetic Transcription;Globus Pallidus;Hippocampus;Human;human model;Hypothalamic structure;Image;improved;Injections;Insula of Reil;Intake;Intervention;Intoxication;Label;Lesion;Life;Light;Liquid substance;male;Measures;men;microscopic imaging;Molecular;mouse model;Mus;neural circuit;neural network;Neurons;Nucleus Accumbens;Oxides;Patients;Perfusion;prevent;promoter;Research;Resistance;response;Rewards;Risk Factors;Rodent;Rodent Model;Role;Saline;sex;sex as a biological variable;Sex Differences;Synapsins;Tactile;Technology;Testing;therapeutic candidate;Time;Tracer;Ventral Striatum;Vertebral column;Viral;Virus;Visual;Water;Woman;Work

PROJECT_TITLE: Role of nucleus accumbens core in ethanol reward and binge-like drinking: Focus on sex as a biological variable


ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: Project Narrative: Our team in South Africa has successfully performed 51 HIV+ to HIV+ kidney transplants. This proposal will build on these positive findings, and utilize this unique population to explore HIV latency, examine causes of organ rejection, and expand access to these life-saving transplants by implementing novel eMedicine programs to strengthen clinical management and support in underserved areas of South Africa.

PI_NAMEs: MULLER, ELMI  (contact)

PROGRAM_OFFICER_NAME: JANCI, ELIZABETH WONDERLICH

PROJECT_TERMS: Affect;Africa;Antithymoglobulin;Area;Biological;Caring;Cells;Cellular Infiltration;Clinical;clinical decision-making;Clinical Management;clinical practice;cohort;Cohort Studies;Communicable Diseases;comorbidity;cytokine;Data;Disease;DNA;Eligibility Determination;End stage renal failure;Environment;experience;Face;follow-up;Functional disorder;graft function;Graft Survival;HIV;HIV Seronegativity;immune activation;Immune response;Immunologics;Immunomodulators;Immunosuppressive Agents;improved;innovation;International;Kidney;Kidney Failure;Kidney Transplantation;Laboratories;Lead;Life;Liver diseases;member;mTOR Inhibitor;novel;Operative Surgical Procedures;Organ;organ transplant recipient;organ transplant rejection;Organ Transplantation;Pathology;Patients;Phase;Population;post-transplant;potential biomarker;prevent;Procedures;programs;Proviruses;Public Health;Research;Risk;Role;Services;South Africa;Spain;success;superinfection;Survival Rate;Tissues;Transplant Recipients;Transplantation;underserved area;uptake;Viral;Viral reservoir;Virus Latency;Work

PROJECT_TITLE: Maximizing the success of HIV+ to HIV+ kidney transplantation in South Africa


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Fibromyalgia;Neurosciences;Pain Research;Prevention

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: This project proposes to understand the sources of pain variability, and demonstrate that pain variability represents fluctuation in natural pain management. The project further proposes to train people to maximize their body’s ability to manage pain, much as increasing athletic performance can be trained.

PI_NAMEs: BISHOP, MARK D. (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Absence of pain sensation;Affect;alternative treatment;American;Area;Athletic;Behavioral;Brain;chronic pain;chronic pain management;clinically relevant;cost;cost estimate;Development;Distal;expectation;experience;Failure;Fibromyalgia;fibromyalgia patients;Impairment;Individual;innovation;Maintenance;Measures;Modeling;Modification;Muscle;Myalgia;negative mood;neural;opioid epidemic;Pain;Pain management;Pain Measurement;pain processing;pain reduction;Performance;Persons;Physiological;prescription opioid;Prevention;Prevention strategy;Preventive treatment;Process;psychologic;Psychological Factors;Public Health;Recovery;Research;resilience;resilience factor;Resolution;response;Site;Source;Stimulus;Structure;System;Testing;Time;Training;Translations

PROJECT_TITLE: Mechanisms and Modification of Pain Modulatory Capacity

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research

PHR: Project Narrative Gene rearrangements involving receptor tyrosine kinases (RTKs) represent a frequent and diverse set of oncogenic driver alterations across human cancer, and resistance to tyrosine kinase inhibitor (TKI) therapies are inevitable for most patients with advanced cancers and the major cause of mortality. We recently discovered that notable RTK fusion oncoproteins form their own pathogenic subcellular compartment, membraneless cytoplasmic RTK protein granules, to coordinate oncogenic RTK and RAS signaling. This proposal will test therapeutic approaches that exploit the unique signaling properties of this cancer-specific biomolecular condensate.

PI_NAMEs: TULPULE, ASMIN  (contact)

PROJECT_TERMS: Address;Adult;Advanced Malignant Neoplasm;Advisory Committees;anaplastic lymphoma kinase;Authorship;Binding;Biology;Biomedical Research;Blood;California;cancer cell;Cancer cell line;Cancer Center;Cancer Etiology;career development;CCDC6 gene;Cell Line;Cell Nucleus;Cell Survival;Cells;Chest;Clinical;Complex;Cytoplasmic Granules;Cytoplasmic Protein;Cytoplasmic Receptors;Data;Dimerization;Disease Progression;disorder control;Doctor of Philosophy;drug development;drug testing;Environment;Extracellular Domain;Funding;Fusion Oncogene Proteins;Gene Rearrangement;Genetic;Goals;growth factor receptor-bound protein 2;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;high resolution imaging;Homodimerization;Human;human cancer mouse model;Imaging Techniques;Individual;inhibitor;inhibitor therapy;Institution;Laboratories;Lead;Lung;Malignant Childhood Neoplasm;Malignant Neoplasms;Mammalian Cell;Mediating;Medicine;meetings;MEKs;Membrane;Membrane Lipids;membrane model;Mentors;Mentorship;Microscopy;Mitogens;Modeling;Molecular;molecular targeted therapies;mortality;mouse model;mutant;Nature;Nucleotides;Oncogenes;Oncogenic;Oncologist;Oncoproteins;Output;Paper;Pathogenicity;patient derived xenograft model;Patients;Pediatric Oncologist;Pediatric Oncology;Phosphorylation;Phosphotransferases;Physical condensation;Physicians;Postdoctoral Fellow;pre-clinical;programs;Proliferating;Property;Protein Isoforms;Protein Kinase;Proteins;PTPN11 gene;Publications;raf Kinases;Ras/Raf;Receptor Protein-Tyrosine Kinases;recruit;Reporting;Research;Research Personnel;Research Support;Resistance;Role;San Francisco;Scientist;self assembly;Signal Transduction;Specificity;standard of care;stem cells;Structure;Subcellular structure;symposium;targeted treatment;teaching laboratory;Techniques;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Training;Transfection;Transmembrane Domain;tumor;tumor xenograft;tumorigenesis;Tyrosine Kinase Inhibitor;United States National Institutes of Health;Universities;Work;Xenograft Model

PROJECT_TITLE: Therapeutic targeting of RTK protein granules in cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Infectious Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE The alarming antibiotic resistance of current pathogens and the emergence of new disease agents have made clear the necessity of increased fundamental scientific investigation into all aspects of infectious diseases. The purpose of the Washington University Training Program in Infectious Diseases/Basic Microbial Pathogenesis is to help fulfill this need by recruiting promising young investigators to this field and training them in outstanding research programs with preeminent investigators who collaborate across multiple disciplines to perform infectious disease research.

PI_NAMEs: GOLDBERG, DANIEL E. (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Infectious Disease/Basic Microbial Pathogenic Mechanisms

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WARWICK

ORG_NAME: KENT COUNTY MEMORIAL HOSPITAL

ORG_STATE: RI

PHR: NARRATIVE This Racial/Ethnic Disparities in Heart Failure: A Cross-Cohort Collaboration study will evaluate the magnitude and potential causes of racial/ethnic and sex disparities in incident heart failure and its subtypes and their prognosis in over 130,000 men and women from 10 pooled cohorts. We will evaluate the impact of hypothetical lifestyle and clinical risk factors interventions on reducing the racial/ethnic disparities in developing HF. In addition using unsupervised machine learning phenomapping techniques, we will evaluate subtypes of HF and their prognosis, including models stratified by race/ethnicity.

PI_NAMEs: ALLEN, NORRINA BAI;EATON, CHARLES B (contact);HOWE, CHANELLE JE'NET

PROGRAM_OFFICER_NAME: KUNZ, JOHN FREDERIC

PROJECT_TERMS: Accounting;adjudication;Affect;African American population;Age;age effect;American;Biological Markers;Cardiac Output;Caucasians;Classification;Clinical;clinical risk;clinically relevant;cohort;Collaborations;comorbidity;Complex;cost;Data;Data Collection;data harmonization;Data Pooling;Death Rate;Diagnosis;Disparity;disparity reduction;Disproportionately impacts women;EFRAC;Epidemiology;epidemiology study;ethnic disparity;ethnic health disparity;Ethnic Origin;Evaluation;Future;Geographic Locations;Goals;health disparity;Heart failure;heart failure with reduced ejection fraction;Heterogeneity;Hospitalization;Incidence;innovation;insight;Intervention;large scale data;learning network;Life Style;lifestyle factors;Longitudinal cohort study;Machine Learning;Measures;Mediation;Medical Records;men;Metabolic;Modeling;mortality;multi-racial;National Heart, Lung, and Blood Institute;neural network;older adult;Outcome;personalized approach;Persons;Phenotype;Physiological;precision medicine;preservation;Prevention strategy;Prevention trial;Preventive measure;Prognosis;prospective;Prospective, cohort study;Public Health;Quality of life;Race;racial disparity;racial health disparity;Reduce health disparities;response;Risk Factors;sex;sex disparity;Symptoms;Syndrome;System;Techniques;Treatment Failure;treatment trial;United States;unsupervised learning;Woman

PROJECT_TITLE: Racial/Ethnic Disparities in Heart Failure: A Cross Cohort Collaboration

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Genetics

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Pre-mRNA splicing is essential for gene expression in all eukaryotes and errors in splicing cause genetic disorders and many other diseases. Understanding the molecular mechanism of splicing has the potential to provide useful approaches for human disease therapy.

PI_NAMEs: ZHAO, RUI  (contact)

PROJECT_TERMS: Biochemical;Complex;Coupling;Disease;Essential Genes;Esterification;Eukaryota;Exons;Gene Expression;Genetic;Genetic Diseases;Genetic Transcription;Genomic approach;Goals;human disease;Introns;Knowledge;Molecular;mRNA Precursor;protein complex;Proteins;Reaction;RNA;RNA Splicing;Small Nuclear Ribonucleoproteins;Spliceosomes

PROJECT_TITLE: The molecular mechanism of pre-mRNA splicing

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Lupus;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Public Health Relevance Infection with enteric pathogens such as Salmonella, Campylobacter, Shigella, or Yersinia are leading causes of morbidity and mortality worldwide. Although in most individuals the infection resolves, approximately 5% of patients develop a painful form of inflammatory arthritis known as reactive arthritis (ReA). In this application, using Salmonella as a model, we will elucidate the mechanisms by which enteric pathogens trigger autoimmunity and ReA.

PI_NAMEs: TUKEL, CAGLA  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Acceleration;Alleles;Amyloid;Ankylosing spondylitis;Antibiotic Therapy;Arthritis;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;Bacteria;Bacterial Infections;Campylobacter;chronic autoimmune disease;chronic infection;Collagen Arthritis;Complex;cytokine;Data;Development;Disease;DNA;DNA receptor;Dose;ds-DNA;Endosomes;enteric infection;enteric pathogen;Enterobacteriaceae;Epithelium;Escherichia coli;Etiology;Exposure to;gastrointestinal infection;Generations;Genetic Predisposition to Disease;Goals;Histocompatibility;HLA Antigens;Human;IL17 gene;Immune;immune activation;Immune system;Immunity;Individual;Infection;Inflammation;Inflammatory Arthritis;Interferon Type I;Intestines;joint inflammation;Leaky Gut;Link;Lupus;Measures;Mediating;Microbial Biofilms;model organism;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;mutant;Oral;Organ;Pain;Pathogenesis;Pathway interactions;Patients;Predisposition;prevent;Preventive;Process;Production;public health relevance;Reiter Disease;Research;response;Role;Salmonella;Salmonella typhimurium;Shigella;Sodium Dextran Sulfate;Structure;Surface;Testing;Therapeutic;Tissues;TLR2 gene;TLR9 gene;Transgenic Mice;Up-Regulation;Wild Type Mouse;Yersinia

PROJECT_TITLE: Molecular mechanisms of Salmonella mediated autoimmunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Precision Medicine

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: U01 Project Narrative Despite extensive research into and highly promising outcomes from cancer immunotherapy, immune-related adverse events remain unpredictable, potentially severe, possibly permanent, and—particularly with combination immunotherapy regimen—relatively common. Our proposed research will capitalize on our team’s years of experience in the genetic and molecular characterization of autoimmune diseases, as well as a previously assembled cohort of hundreds of patients treated with immune checkpoint inhibitor therapy for cancer, to perform, analyze, integrate, and validate biomarkers for the prediction of immune checkpoint inhibitor efficacy and toxicity. These findings may ultimately be used to guide patient selection, treatment, and monitoring, thereby impacting public health at a high level in both the near- and long-term.

PI_NAMEs: GERBER, DAVID ERIC (contact);WAKELAND, EDWARD K.;XIE, YANG

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Address;adjudication;assay development;Autoantibodies;Autoimmune Diseases;Autoimmunity;Bioinformatics;Biological Assay;Biological Markers;Biology;biomarker panel;biomarker validation;Blood specimen;cancer immunotherapy;Cancer Patient;cancer therapy;Cellular Immunity;checkpoint therapy;chemokine;chemotherapy;Classification;Clinical;clinical application;Clinical Data;clinical efficacy;Clinical Trials;clinically significant;cohort;Collaborations;Combination immunotherapy;Complex;Correlative Study;cytokine;Cytometry;Cytotoxic T-Lymphocytes;Data;Data Analyses;data integration;Data Set;Databases;Development;Disease;DNA Resequencing;Equilibrium;Event;Exclusion;experience;Funding Mechanisms;Future;Genetic;Goals;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immune Tolerance;immune-related adverse events;immunological diversity;Immunology;immunoregulation;Immunotherapy;Incidence;Inflammatory;insight;Institute of Medicine (U.S.);Interdisciplinary Study;Laboratories;Molecular;molecular targeted therapies;Monitor;multidisciplinary;Musculoskeletal;Organ;Outcome;Pathway interactions;Patient Selection;Patients;Pattern;Peripheral Blood Mononuclear Cell;Phenotype;Population;predictive marker;Protocols documentation;Public Health;Publishing;Recommendation;Recording of previous events;Regimen;Research;Research Personnel;Resources;Sampling;Severities;single-cell RNA sequencing;SNP array;T cell receptor repertoire sequencing;T-Lymphocyte Subsets;Testing;Time;Toxic effect;tumor;Tumor Biology;tumor immunology;Validation;Variant

PROJECT_TITLE: Finding the optimal balance of immunotherapy efficacy and toxicity.


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Orphan Drug;Pediatric;Precision Medicine;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Bronchiolitis obliterans syndrome (BOS) is an irreversible obstructive lung disease and a significant cause of morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients. HSCT patients are often referred for pulmonary evaluation only after significant respiratory decline due to the relative insensitivity of spirometry, especially in young children, and as a result, BOS is often undiagnosed until the disease has progressed beyond the point where therapy will significantly improve the disease course and outcome. The proposed research will identify novel biomarkers for early diagnosis of BOS post HSCT and establish a dynamic prediction model for BOS to provide a platform for testing future preventive and therapeutic interventions.

PI_NAMEs: MYERS, KASIANI  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: active method;Address;Adult;airway obstruction;Algorithms;Behavior;Biological Markers;biomarker validation;Black Box;Blinded;Blood;Bronchiolitis Obliterans;candidate marker;candidate validation;Caring;Child;Childhood;Climacteric;Clinic;Clinical;Clinical Data;clinical diagnosis;Clinical Trials;cohort;cost;Cystic Fibrosis;Data;Data Analyses;Death Rate;Detection;Development;Diagnosis;Diagnostic;Disease;Early Diagnosis;Early Intervention;Enzyme-Linked Immunosorbent Assay;Evaluation;Evolution;Fibrosis;Future;Generations;Goals;graft vs host disease;Health Care Costs;Hematopoietic Stem Cell Transplantation;high risk;high risk population;Hospitalization;Immune;Immune response;improved;Incidence;Individual;individual patient;Inflammation;Inflammatory;innovation;Intervention;Knowledge;longitudinal analysis;Lung;Lung Diseases;Mass Spectrum Analysis;Medical;Monitor;Morbidity - disease rate;mortality;new therapeutic target;novel;novel marker;Obstructive Lung Diseases;optimal treatments;Outcome;Pathway interactions;patient population;Patients;Penetration;Performance;Plasma;Plasma Proteins;point of care;Population;post-transplant;prediction algorithm;predictive marker;predictive modeling;predictive tools;Prevention;Prevention trial;preventive intervention;Probability;Procedures;prophylactic;prospective;Prospective Studies;protein biomarkers;Protein Isoforms;Proteomics;pulmonary function;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;repository;Research;respiratory;Risk;risk stratification;Sampling;screening;Severity of illness;Specificity;Spirometry;Statistical Data Interpretation;Stratification;Supportive care;Syndrome;tandem mass spectrometry;Techniques;Testing;Therapeutic Intervention;Time;timeline;tool;Transplant Recipients;Transplantation;treatment trial;Validation;Work;young adult

PROJECT_TITLE: Penetrating the “Black box”:  Prediction of early Bronchiolitis obliterans in Pediatric Hematopoietic Stem Cell Transplant Recipients

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The pacemaker cells that reside within the cardiac inflow tract are essential for setting the rhythm of the heartbeat. Despite their importance, the mechanisms responsible for establishing an appropriate number of specialized pacemaker cells at the inflow tract are not yet understood. Identification of the genetic pathways that regulate inflow tract formation has the potential to improve our comprehension of the causes of congenital heart disease and may inspire new strategies for regenerative medicine.

PI_NAMEs: CHI, NEIL C;YELON, DEBORAH  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: antagonist;Anterior;Arrhythmia;Cardiac;Cardiac Myocytes;Characteristics;Comprehension;congenital heart abnormality;Data;Development;Dimensions;Disease;Embryo;Embryonic Heart;Erinaceidae;Evaluation;Future;gain of function;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Epistasis;Heart;Heart Atrium;improved;innovation;insight;Lateral;Ligands;loss of function;Maps;Mesoderm;Modeling;Molecular;molecular modeling;Molecular Profiling;mosaic analysis;mutant;Myocardium;network models;nodal myocyte;novel;Organ;Organism;Organogenesis;Pacemakers;Pathway interactions;Pattern;pharmacologic;Phase;Play;predictive modeling;Process;progenitor;Property;regenerative approach;Regenerative Medicine;Regulation;Resolution;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;smoothened signaling pathway;spatial integration;Specific qualifier value;Specificity;stem cells;Testing;Tissues;transcriptomics;WNT Signaling Pathway;Work;Zebrafish

PROJECT_TITLE: Genetic regulation of cardiac inflow tract formation in zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C(02)]


NIH_SPENDING_CATS: Cardiovascular;Digestive Diseases;Genetics;Heart Disease;Human Genome;Microbiome;Nutrition;Organ Transplantation;Transplantation

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE The long-term survival rate in cardiac transplantation is poor, and immune-mediated damage remains as the primary cause of chronic graft failure. This study addresses major knowledge gaps in the mechanisms by which the gut microbiome induces immune modulation that could prolong immunologic quiescence to improve graft survival. This is a fundamental step towards novel advances in diagnosis and preventive therapeutics against graft rejection to improve health and quality of life, all of which are within the mission of NIAID.

PI_NAMEs: BROMBERG, JONATHAN S;MA, BING  (contact);MAS, VALERIA RAQUEL

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: acylcarnitine;Address;Alloantigen;Allografting;Amines;Anaerobic Bacteria;Anti-Inflammatory Agents;Antibiotics;Atherosclerosis;Automobile Driving;B-Lymphocytes;Bacteria;Bacteroides;Bifidobacterium;Bile Acids;Blood;Cardiac;cell motility;cell type;Cells;Characteristics;Chronic;clinically relevant;Communities;Complex;Congestive Heart Failure;cytokine;Data;Death Rate;Dendritic Cells;Desulfovibrio;Diagnosis;Diagnostic;Drug Exposure;dysbiosis;Endothelial Cells;Endotoxins;Epithelium;Equilibrium;fatty acid metabolism;fecal microbiota;Fiber;Fibrosis;Functional disorder;Goals;graft failure;Graft Rejection;Graft Survival;gut microbiome;Health;heart allograft;Heart Transplantation;Immune;Immune response;Immunity;Immunologics;immunoregulation;Immunosuppression;Immunosuppressive Agents;improved;Inflammation;Inflammatory;Inflammatory Response;Injury;interstitial;Intervention;intestinal barrier;intestinal epithelium;intestinal injury;Intestines;isoimmunity;Knowledge;Lactobacillus;Laminin;Lead;Ligands;liver injury;lymph nodes;Lymphatic;Macrophage;Mediating;Mesentery;Metabolic;Metagenomics;microbial;microbial community;microbiome;Mission;Molecular;mouse model;Mucous Membrane;Mus;Myeloid Cells;National Institute of Allergy and Infectious Disease;novel;Outcome;Oxides;Pathologic;Permeability;permissiveness;Pharmaceutical Preparations;Play;post-transplant;pregnant;Preventive;Quality of life;Regulatory T-Lymphocyte;response;Reticular Cell;Role;Serum;single nucleus RNA-sequencing;Structure;Survival Rate;systemic inflammatory response;T-Lymphocyte;Therapeutic;Therapeutic Intervention;tool;transcriptomic profiling;transplant model;Transplantation;Vascular Diseases;Volatile Fatty Acids;Work

PROJECT_TITLE: Mechanisms of microbiome-driven cardiac allograft outcomes


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Infectious Diseases;Inflammatory Bowel Disease;Microbiome

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative Intestinal fungi are an important component of the microbiota, and recent studies have unveiled their potential in modulating inflammatory disease. Nonetheless, the mechanisms governing immunity to gut fungi (gut mycobiota) remain unknown. In this proposal, we will study a network of immune cells in the gut, called phagocytes, with superior capability to sense, interact (phagocyte) and respond to fungi during health and during intestinal disease.

PI_NAMEs: ILIEV, ILIYAN DIMITROV (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: adaptive immune response;adaptive immunity;Affect;Aggravated Colitis;anti-fungal agents;Antibody Formation;Antigens;Bacteria;bacterial community;Bacterial Infections;C Type Lectin Receptors;Candida;Candida albicans;Cells;Characteristics;chemokine;Chronic;Colitis;Collection;commensal bacteria;Communities;computational pipelines;computational platform;conditional knockout;Coupled;CX3CR1 gene;cytokine;Data;dectin 1;Defect;defined contribution;Dendritic Cells;Development;dextran sulfate sodium induced colitis;Disease;Disease Outcome;DNA Sequence Alteration;dysbiosis;Engineering;Evolution;experimental study;fractalkine receptor;Functional impairment;Fungal Antigens;fungal microbiota;fungus;Gastrointestinal tract structure;Genes;Genetic;Genetic Polymorphism;genome sequencing;Germ-Free;Growth;gut bacteria;gut inflammation;Health;Homeostasis;Human;Hypersensitivity;Immune;Immunity;In Vitro;in vivo;in vivo Model;Individual;Infectious Skin Diseases;Infiltration;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory milieu;inflammatory modulation;Inflammatory Response;Innate Immune Response;insight;Integrins;Interleukin-10;Intestinal Diseases;Intestines;Intrinsic factor;ITGAM gene;Knock-out;Knockout Mice;Knowledge;Lead;Lung;Lung infections;Macrophage;Mediating;microbiota;Modeling;monocyte;Mononuclear;mouse model;Mucosal Immunity;murine colitis;Mus;mycobiome;Natural Immunity;oral infection;pathogenic bacteria;pathogenic fungus;Pathology;Patients;Phagocytes;Pharmaceutical Preparations;Phenotype;Play;Population;Pulmonary Inflammation;Rag1 Mouse;receptor;Receptor Signaling;receptor-mediated signaling;Regulation;Regulatory T-Lymphocyte;Resolution;response;Role;Severities;Shapes;Side;Site;T-Lymphocyte;targeted treatment;Testing;Transgenic Organisms;Ulcerative Colitis;vaginal infection;Virus;whole genome;Work

PROJECT_TITLE: Mononuclear phagocyte networks in mycobiota regulation and antifungal immunity.

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Rare Diseases;Tuberculosis

PI_NAMEs: S�RAPHIN, MARIE NANCY (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Accounting;Address;Age;Archives;base;Clinical;Cluster Analysis;Communities;Contact Tracing;Data;Decontamination;deep sequencing;Detection;Disease Outbreaks;Ebola;effective therapy;Epidemiology;epidemiology study;Fostering;Genetic;Genetic Variation;Genome;genome sequencing;Genomics;Genotype;Ghana;Goals;guanidinium;high risk;Household;immunological status;Incidence;Influenza A virus;Intervention;Investigation;Laboratories;Lead;Link;Measurement;Measures;Methods;Morbidity - disease rate;mortality;multidisciplinary;Mycobacterium tuberculosis;Newly Diagnosed;novel strategies;outbreak control;Participant;Patient Recruitments;Persons;Pilot Projects;prevent;Probability;Prophylactic treatment;prospective;Protocols documentation;Proxy;Public Health;rapid detection;rapid diagnosis;Research;Resolution;Sampling;Single Nucleotide Polymorphism;Sodium Hydroxide;spatiotemporal;Specimen Handling;Sputum;Structure;Testing;transmission process;Tuberculosis;Tuberculosis diagnosis;Variant;Virulence;whole genome

PROJECT_TITLE: Linking within- and between-host dynamics in tracking recent Mycobacterium tuberculosis transmission


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: Kidney cancer is among the most common malignancies in both men and women. It is highly prevalent in the Veteran population as analysis of VA Central Cancer Registry Data indicates that cancer of the kidney is among the most common tumor types. Kidney tumors undergo extensive changes in their metabolism as compared with the normal kidney. These includes alterations in the metabolism of amino acids, the basic building blocks of protein. Notably, these changes are found in other tumor types that commonly impact Veterans. The goal of this proposal will be to determine how these changes occur in kidney tumors and their biologic significance. Specifically, we will determine how these changes accelerate tumor growth. We will also determine how these changes contribute to metastasis, an event that portends a poor prognosis for patients. The overarching goal will be to identify novel strategies that can be translated into the clinic to improve the outcomes of Veterans with kidney cancer.

PI_NAMEs: SUDARSHAN, SUNIL  (contact)

PROJECT_TERMS: Acceleration;Address;Aggressive behavior;amino acid metabolism;Amino Acids;Behavior;Biological;Branched-Chain Amino Acids;cancer cell;carcinogenesis;Catabolism;Cessation of life;chromatin remodeling;Clear cell renal cell carcinoma;Clinic;Common Neoplasm;Complex;Data;data registry;Diet;dietary;Disease;Enzymes;Epigenetic Process;epigenome;Essential Amino Acids;Event;Gene Expression;Genes;genome-wide;Glycolysis;Goals;Growth;Histology;Histone Deacetylase;Histone Deacetylase Inhibitor;Human body;Hypoxia Inducible Factor;improved;improved outcome;in vivo;innovation;insight;Intervention;Invaded;Isoleucine;Kidney;Kidney Neoplasms;Leucine;Link;Malignant Neoplasms;Mediating;men;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolism;metabolomics;migration;military veteran;Mitochondria;Modeling;Molecular;Neoplasm Metastasis;neoplasm registry;neoplastic cell;novel;novel strategies;Organ;Pathway interactions;patient derived xenograft model;patient prognosis;Patient-Focused Outcomes;Patients;pharmacologic;Phenotype;Population;programs;Proliferating;promoter;Proteins;rapid growth;Reaction;Renal Carcinoma;Renal Cell Carcinoma;Role;Route;Sampling;Series;Signal Transduction;Stable Isotope Labeling;Testing;Therapeutic;Translating;tumor;tumor behavior;Tumor Biology;tumor growth;tumor metabolism;tumor progression;Valine;Veterans;Woman;Work;Xenograft Model

PROJECT_TITLE: HDAC7-driven metabolic remodeling in renal tumor progression


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Health Services;Immunization;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Project Narrative This study aims to assess the implementation and preliminary effectiveness of a gender-transformative family planning program linked with infant vaccination services to improve postpartum contraceptive access and use. This intervention is relevant to public health because it has the potential to reduce unintended pregnancy and short inter-pregnancy intervals, thereby decreasing maternal and infant morbidity and mortality.

PI_NAMEs: AVERBACH, SARAH  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: acceptability and feasibility;Address;Agreement;arm;Behavior;behavior influence;Belief;Birth;Caring;Child;Childhood;Clinic;Communities;community center;Contraceptive Agents;contraceptive effectiveness;Contraceptive methods;Contraceptive Usage;Counseling;Country;Couples;Data;Decision Making;design;Development;Dose;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;Eligibility Determination;Evidence based intervention;expectation;Family;Family Planning;Family Planning Center;Family Planning Programs;follow-up;Frequencies;Gender;gender equity;Gender Role;Grant;Health;Husband;Hybrids;Immunization Programs;implementation evaluation;implementation outcomes;Improve Access;improved;India;Individual;Inequality;Inequity;Infant;infant morbidity/mortality;innovation;Intervention;Interview;Intrauterine Devices;Link;male;maternal morbidity;maternal risk;Measures;Methods;Modeling;Nurses;nutrition;outreach;Participant;Patient Self-Report;Perception;Persons;pilot test;pilot trial;postpartum contraception;Postpartum Period;Postpartum Women;Pregnancy;prevent;Proctor framework;programs;Provider;Public Health;Qualitative Research;Quality of Care;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;reproductive;Resources;Rural;rural setting;Schedule;Services;social expectations;standard of care;Structure;Surveys;Target Populations;unintended pregnancy;uptake;Vaccination;Vaccines;Visit;Woman;Work;young woman

PROJECT_TITLE: Increasing access to postpartum contraception by linking family planning and infant vaccination services

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: Public Health Relevance Statement Reducing suicides and premature mortality among youth with depression has been identified as a national priority and an important goal for health systems, yet no studies have examined the impact of pediatric depression care meeting quality standards on important patient outcomes such as depression recurrence, self- harm, suicide, and overall mortality. In response to FOA PAR 17-264, the proposed research uses national Medicaid data linked with mortality data for youth aged 10 to 17 with a new episode of Major Depression to examine determinants and consequences of guideline concordant depression care. Evidence from this study will inform and guide more effective clinical practices and policies for the care of children and adolescents with major depressive disorder.

PI_NAMEs: FONTANELLA, CYNTHIA ANN (contact)

PROGRAM_OFFICER_NAME: KARACA, ZEYNAL

PROJECT_TITLE: Improving Quality and Outcomes for Low Income Children with Depression in the US

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Control of immune defenses in the intestine is critically important for human health. This project will characterize new mechanisms of immune activation and regulation in the cells that line the intestine. We anticipate that this work will offer fundamental insights into pathogen sensing and immune control of importance to all metazoan hosts, including humans.

PI_NAMEs: PUKKILA-WORLEY, READ  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Amino Acids;Bacteria;bacterial metabolism;Binding;Biological Response Modifiers;Caenorhabditis elegans;Cell Line;Cell Physiology;Chemicals;Cytoprotection;Dangerousness;Data;density;Disease;Environment;Epithelial Cells;Family;Funding;Genes;Genetic;Genetic Transcription;Goals;gut inflammation;Habitats;Health;HNF4A gene;Homologous Gene;Human;Immune;immune activation;Immune signaling;Immunity;Immunologic Surveillance;immunoregulation;Infection;Inflammatory Response;Injury;innovation;insight;intestinal epithelium;Intestines;Ligand Binding;Ligand Binding Domain;Ligands;member;Metabolism;Microbial Biofilms;Molecular Structure;Natural Immunity;Nematoda;Nuclear Family;Nuclear Hormone Receptors;Nuclear Receptors;Organism;Orphan;pathogen;Pathogen detection;pathogenic bacteria;Pattern Recognition;Pattern recognition receptor;Phenazines;Physiological Processes;Physiology;prevent;promoter;Protein Family;Proteins;Pseudomonas aeruginosa;receptor function;Resistance;Role;sensor;Signal Pathway;surveillance network;Surveys;Testing;therapeutic target;Tissues;Toll-like receptors;transcription factor;treatment response;Work;X-Ray Crystallography

PROJECT_TITLE: An Immune Surveillance Network in C. elegans

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Lupus;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Twenty-five percent of individuals in the U.S. have a chronic rheumatic condition including arthritis and many have increased risk of severe COVID-19 from these conditions, related comorbidities or immunosuppressive medications. COVID-19 vaccination hesitancy persists in this population, particularly among Black individuals who suffer disproportionately from serious infections and poorer outcomes compared to White individuals. Our community-academic partnership will design, implement and evaluate an intervention that trains community leaders with rheumatic conditions to disseminate vaccine-related information through their social networks in Black communities to promote racial justice in vaccine uptake.

PI_NAMEs: FELDMAN, CANDACE HILLARY;RAMSEY-GOLDMAN, ROSALIND  (contact)

PROJECT_TERMS: acute care;Address;adverse outcome;Advocacy;Area;arm;Arthritis;Assessment tool;black patient;Black Populations;Black race;Boston;Caring;Characteristics;Chicago;Chronic;Cities;Clinical Trials;Communicable Diseases;Communities;community academic partnership;community intervention;comorbidity;COVID-19 burden;COVID-19 pandemic;COVID-19 stress;COVID-19 vaccination;COVID-19 vaccine;Critical Race Theory;density;design;Disease Outcome;Disease susceptibility;Disparity;Education;Educational Curriculum;Educational Intervention;empowerment;ethnic disparity;Evaluation;evidence base;Exhibits;experience;forging;Fright;General Population;Goals;Health;health care availability;health care disparity;high risk;high risk population;Immunocompromised Host;immunosuppressed;improved;Individual;Infection;Information Dissemination;Intervention;Interview;Justice;Knowledge;lens;long-standing disparities;low socioeconomic status;Lupus;Maps;member;Methods;Modeling;mortality;Outcome;outreach;Patients;people of color;Persons;Pharmaceutical Preparations;physically handicapped;Physicians;Play;Population;Positioning Attribute;Process;Public Health;Race;racial disparity;racism;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Regimen;Research;response;Rheumatism;Rheumatoid Arthritis;Rheumatology;Risk;Role;Safety;SARS-CoV-2 infection;severe COVID-19;social health determinants;Social Network;social network intervention;Societies;socioeconomic disparity;standard of care;Structural Racism;Structure;Systemic Lupus Erythematosus;Testing;Training;Training Activity;transmission process;treatment arm;trial enrollment;Trust;Underrepresented Minority;uptake;Vaccinated;Vaccination;vaccine acceptance;vaccine efficacy;vaccine hesitancy;vaccine response;vaccine safety;Vaccines;virtual;Work

PROJECT_TITLE: Leveraging Community-Academic Partnerships and Social Networks to Disseminate Vaccine-Related Information and Increase Vaccine Uptake Among Black Individuals with Rheumatic Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-V(90)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative  The paradigm-shifting discoveries in RNA modiﬁcations have added RNA to the picture of dynamic regulation of gene expression through reversible chemical modiﬁcations. Successful transcriptome- wide proﬁling of RNA modiﬁcations can signiﬁcantly advance the frontier of epitranscriptomics research and associate epitranscriptomic variations with human health and diseases. The aim of this proposal is to develop bioinformatics infrastructures and computational tools for epitranscriptomics studies.

PI_NAMEs: CHEN, MENGJIE  (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Achievement;Address;Affect;Affinity;Alleles;base;Base Pairing;bioinformatics infrastructure;Biological Assay;Biological Process;Biology;Biotechnology;Catalogs;cell type;Chemicals;Communities;Complex;computerized tools;Computing Methodologies;Data;Data Set;Databases;Detection;Development;Dimensions;Disease;DNA;epitranscriptome;epitranscriptomics;Foundations;frontier;Gene Expression Regulation;Genes;genetic information;Genetic Transcription;genomic data;Genomics;Goals;Health;Human;human disease;Induced Mutation;Innate Immune Response;interest;Measures;Messenger RNA;Metabolism;Methods;Methylation;Modification;Molecular;Mutation;Nature;novel;novel strategies;Nucleotides;Organism;Pathway interactions;Phase;Phenotype;Post-Transcriptional Regulation;protein function;Proteins;Protocols documentation;Publishing;rapid growth;Regulation;Research;Research Personnel;Resolution;Resources;RNA;RNA methylation;RNA-Binding Proteins;Role;Single Nucleotide Polymorphism;Specificity;Standardization;Statistical Methods;Statistical Models;Structure;success;Technology;Tissues;transcriptome;transcriptomic profiling;Translations;user friendly software;Variant;web portal;web server

PROJECT_TITLE: Develop new bioinformatics infrastructures and computational tools for epitranscriptomics data

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The novel coronavirus 2019 (COVID) pandemic is the most significant Public Health crisis of the past century, and African-Americans are disproportionately impacted-- with rates of COVID-19 infection and mortality that are 2 to 4 times higher than those in Whites. Because most research on COVID-19 has focused on the physiological consequences of the disease, we know almost nothing about the psychosocial impact of COVID- 19, particularly in the most vulnerable groups. The goal of the proposed project is to examine the impact of COVID-related psychosocial stressors on vascular aging in a cohort of African-American women.

PI_NAMEs: LEWIS, TENÉ T (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: 2019-nCoV;Affect;African American;African American population;African American Women;Aging;arterial stiffness;attributable mortality;Blood Pressure;Blood Vessels;Businesses;Child;Child Rearing;cohort;Coronavirus;Country;COVID-19;COVID-19 disparity;COVID-19 impact;COVID-19 mortality;COVID-19 pandemic;COVID-19 stress;Dangerousness;Death Rate;Discipline of Nursing;Disease;Employment;experience;Exposure to;fast food;Financial Hardship;Funding;Gender;Goals;Health;Heterogeneity;Home;Individual;Inequality;infection rate;Inflammation;innovation;Life;Light;Loneliness;low socioeconomic status;maltreatment;Marital Status;Marriage;men;middle age;mortality;novel coronavirus;Occupations;optimism;pandemic disease;pandemic stress;Personal Satisfaction;Physiological;Populations at Risk;Positioning Attribute;post-COVID-19;post-pandemic;Prevention;prospective;psychosocial;Psychosocial Assessment and Care;Psychosocial Stress;psychosocial stressors;Public Health;Race;racial difference;racial disparity;Reporting;Research;resilience;resilience factor;Resources;SARS-CoV-2 infection;Schools;self-compassion;Single Parent;social stressor;Social support;sociodemographic factors;Socioeconomic Status;Stress;stressor;Time;Underemployment;Unemployment;United States;Vascular Diseases;Virus;Vulnerable Populations;Wages;White Women;Woman;Work;Workplace

PROJECT_TITLE: Psychosocial Stress due to COVID-19 and Vascular Aging in African-American Women


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: The goal of this basic research proposal is to characterize a novel enzymatic activity whose loss we find to be associated with neurodegeneration in mice and humans, and to determine to what extent this activity plays a protective role against cytotoxicity. By elucidating molecular mechanisms underlying neurodegenerative disorders, the proposed work is expected to open the way to the development of new therapeutic rationale and approaches.

PI_NAMEs: BURGESS, ROBERT W. (contact);COX, GREGORY A.;JOAZEIRO, CLAUDIO A.P.

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Address;aging population;Alanine;Amyotrophic Lateral Sclerosis;Bacteria;base;Basic Science;Behavioral;Binding;Biochemical;Biological Assay;Biology;C-terminal;causal variant;Cell model;Cells;cofactor;Complex;cytotoxicity;Data;Defect;design;Development;Disease;early onset;Ethylnitrosourea;Etiology;Exhibits;fitness;Functional disorder;Funding;Genes;Goals;Histopathology;Human;human disease;Induced Mutation;Inherited;insight;Intervention;Investigation;Knowledge;Lead;Light;loss of function;Mammalian Cell;Mediating;Modeling;Modification;Molecular;Motor;Motor Neuron Disease;Motor Neurons;mouse model;Mouse Strains;Mus;mutant;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neurodegenerative phenotype;Neuromuscular conditions;Neuromuscular Diseases;Neurons;neuroprotection;Nitrosourea Compounds;novel;novel therapeutics;Nuclear Export;Orthologous Gene;Paralysed;Patients;Phenocopy;Phenotype;Play;polyalanine;polypeptide;Post-Translational Protein Processing;Prevalence;protein aggregation;Proteins;Proteolysis;Public Health;Quality Control;Reporting;Research;Research Proposals;Ribosomes;Role;Societies;Spinal Cord;sporadic amyotrophic lateral sclerosis;System;Tail;Testing;therapeutically effective;Tissues;Toxic effect;Translations;ubiquitin-protein ligase;Variant;Work;Yeasts

PROJECT_TITLE: Polyalanine Tails: A Novel Type of Protein Modification Implicated in  Neurodegeneration

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE If humans lose their reproductive cells (i.e. eggs and sperm) they become infertile, in contrast, some animals regenerate their reproductive cells and reproductive organs. This project’s goal is to uncover the mechanisms of reproductive cell and tissue regeneration by identifying the cell types and genes involved in this process. Through its focus on reproductive cell regeneration, stem cell activity, and cell reprogramming, our project will contribute to our fundamental knowledge of reproductive and stem cell biology and will inform regenerative medicine approaches.

PI_NAMEs: OZPOLAT, BUSRA DUYGU  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Address;Adolescent;Adult;Anatomy;Animals;Annelida;Cell Lineage;Cell model;cell regeneration;Cell Reprogramming;cell type;Cells;Cellular biology;Databases;Dedications;Development;Drosophila genus;egg;Future;Genes;Genetic;Genome;Germ Cells;Germ Lines;Goals;Human;Image;Infertility;Knowledge;Laboratories;Life;Modernization;Molecular;Multipotent Stem Cells;Mus;Natural regeneration;Nematoda;neuronal cell body;Organism;Platyhelminths;Population;Postembryonic;prevent;Process;Regenerative Medicine;reproductive organ;Research;single-cell RNA sequencing;Somatic Cell;Source;sperm cell;Starfish;stem cell biology;stem cell self renewal;stem cells;Techniques;Testing;tissue regeneration;tool;transcriptome;transcriptomics;transdifferentiation;Transgenic Organisms

PROJECT_TITLE: Cellular and Molecular Mechanisms of Germline Regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE  Three specific aims are proposed in this R01 application to investigate the important but long-standing question regarding how stromal androgen signaling controls prostatic epithelial cell differentiation, growth, and regeneration. Data generated from this study will greatly enhance our current knowledge in the fields of androgen signaling, stem cell niches, and prostate development.

PI_NAMEs: SUN, ZIJIE  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Address;Adult;Affect;aging population;Androgen Receptor;Androgens;AR gene;base;Benign Prostatic Hypertrophy;Biological;Biological Assay;Bladder;Castration;Cell Differentiation process;cell growth;Cells;Complete Androgen-Insensitivity Syndrome;Complex;Data;Development;Disease;effective therapy;Embryo;Embryonic Development;Endocrine Glands;Epithelium;experimental study;Future;Growth;Growth Factor;Healthcare Systems;Homeostasis;Human;insight;Knowledge;male;Malignant Neoplasms;Mediating;Mesenchymal;Mesenchyme;Morbidity - disease rate;Morphogenesis;mouse genetics;mouse model;Mus;Mutation;Natural regeneration;Neck;paracrine;Pathogenesis;Play;pluripotency;postnatal;prepuberty;Proliferating;Property;Prostate;Prostatic;Prostatic Epithelium;prostatitis;Puberty;Receptor Activation;Receptor Signaling;reproductive;Research;Resistance;Role;Series;SHH gene;Signal Pathway;Signal Transduction;smoothened signaling pathway;stem cell function;stem cell niche;stem cells;Stromal Cells;Testing;Time;Tissue Recombination;tool;Urethra;Urogenital Sinus;Withdrawal

PROJECT_TITLE: Androgen Signaling in Prostatic Sonic Hedgehog Responsive Cells

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative As tragically evidenced by COVID-19, epidemics can surge dramatically, change continually, and significantly strain health systems, for example with the SARS-CoV-2 virus (to-date) infecting over 250 million worldwide, killing over 5 million, and impacting safe equitable care, including makeshift rooming, equipment and staff shortages, rationed care, and other crisis management. As in past epidemics, affected regions and states were unprepared to handle unpredictable and significantly differing local surges in timing, severity, duration, and re- currence, with broad agreement of the need to be better prepared for future epidemics, including how best to leverage facility-level operational models to safely manage care capacity surges. This project thus will refine, evaluate, and study the use, accuracy, and impact on patient, staff, and system safety of novel facility-specific 30-day ahead rolling bed, equipment, and staff surge capacity models, evaluating performance under a wide range of past and future scenarios via both retrospective COVID-19 data from varied health partners and pro- spective computer simulation of future epidemics.

PI_NAMEs: BENNEYAN, JAMES C (contact)

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Epidemic Surge Model Use to Improve Patient, Staff, and System Safety and Resiliency

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Rare Diseases

PHR: Project Narrative Innate immune signal transduction pathways are major targets of bacterial toxins and effector proteins. This proposal examines the ability of a family of bacterial type III effector proteins to hijack human signaling enzymes. Gaining a deeper understanding of how these bacterial effectors hijack components of the host inflammasome using biochemistry, X-ray crystallography, and in vivo models will lead to a more complete knowledge of numerous pathogenic mechanisms and may reveal new aspects of signal transduction in the human host cell.

PI_NAMEs: ALTO, NEAL MATHEW (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: 17q12;26S proteasome;Asthma;Bacteria;bacterial genetics;Bacterial Toxins;Biochemical;Biochemistry;Biological Assay;Cell Death;Cell Death Induction;Cells;Cessation of life;Chronic Disease;Colon;combat;Communicable Diseases;Communication;Crohn's disease;Cytolysins;Cytolysis;Defense Mechanisms;design;Development;Disease;Disease Progression;Drug Targeting;Emerging Communicable Diseases;Enteral;enteric pathogen;Enzymes;Epithelial Cells;Escherichia coli;Escherichia coli EHEC;Escherichia coli O157:H7;Eukaryotic Cell;Event;Evolution;Exhibits;Family;Family member;Genes;Genetic Polymorphism;Genetic study;genome wide association study;Glean;Goals;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;high risk;Host Defense Mechanism;Human;human pathogen;humanized mouse;Immune;Immune signaling;Immune system;Immunologics;In Vitro;in vivo;in vivo Model;Infectious Diseases Research;Inflammasome;Inflammatory;Innate Immune Response;Innate Immune System;innovation;Insulin-Dependent Diabetes Mellitus;Invaded;Knowledge;Link;Lipids;Lung;Lytic;Mammalian Cell;Mediating;member;Membrane;Modeling;Molecular;Molecular Evolution;mouse model;Mucous Membrane;Multienzyme Complexes;mutant;new therapeutic target;novel;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Persons;Physiological;Play;Population;Primary biliary cirrhosis;Primates;Prokaryotic Cells;Proteins;reconstitution;Regulation;Research;Resolution;Role;Rupture;Shigella;Shigella flexneri;Shigella Infections;Signal Transduction;Signal Transduction Pathway;Structure;Structure of parenchyma of lung;System;Testing;theories;Tissues;Transgenic Mice;Type III Secretion System Pathway;ubiquitin-protein ligase;Ubiquitination;Virulence;Virulence Factors;Work;X-Ray Crystallography

PROJECT_TITLE: Type III effector regulation of host signal transduction systems

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

PHR: The goal of this project is to support research programs dedicated to understanding the role of epitranscriptomic regulation of mRNA expression in the brain, the role of RNA-directed epigenetic silencing in fragile X syndrome, and to develop new technologies to image and manipulate synaptic mRNA.

PI_NAMEs: JAFFREY, SAMIE R (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Animals;aptamer;Area;Biology;Brain;CGG repeat;Complementary DNA;Dedications;Disease;Engineering;Epigenetic Process;epigenetic silencing;epitranscriptomics;Fragile X Syndrome;Goals;Hybrids;Image;imaging approach;insight;Knowledge;Laboratories;Light;Messenger RNA;Modification;mRNA Expression;mRNA Translation;neural circuit;Neurologic;Neurons;new technology;novel;novel strategies;Nucleotides;Pathway interactions;Pattern;Post-Transcriptional Regulation;programs;Protein Biosynthesis;Regulation;Research;Research Support;RNA;Role;Spinach - dietary;Synapses;synaptic function;Synaptic plasticity;Technology;transcriptome

PROJECT_TITLE: New mechanisms and technologies for understanding post-transcriptional gene regulation in neurons


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is a devastating, fatal illness that will affect more than 10 million Americans by mid-century. The ε4 allele of the Apolipoprotein E gene (APOE4) is a common, potent risk factor for AD, found in more than half of patients. The current study will aim to understand how local genetic variants near APOE4 (and other AD-relevant genes) alter the structure and amount of the gene’s protein and how that impacts AD risk.

PI_NAMEs: GREICIUS, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Affect;African American;African American population;African ancestry;Alleles;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;American;Apolipoprotein E;Brain Diseases;brain tissue;Disease;DNA;DNA Sequence Alteration;drug development;European;European ancestry;Fibroblasts;Gene Proteins;Genes;Genetic Diseases;genetic risk factor;genetic variant;genome sequencing;Genomics;Individual;Leukocytes;Literature;new therapeutic target;patient subsets;Patients;Persons;Proteins;RNA;Structure;Technology;Variant;whole genome

PROJECT_TITLE: Illuminating the APOE Locus with Long-Read Sequencing and Targeted Genomics


NIH_SPENDING_CATS: Bioengineering;Immunization;Infectious Diseases;Lyme Disease;Nanotechnology;Prevention;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE  Acquired resistance to ticks is commonly known as “tick resistance”. This proposal seeks to elucidate the antigens in Ixodes scapularis saliva that contribute to the development of tick resistance and characterize the host response to these antigens. This will lead to important new information that can be used to develop a novel vaccine to prevent Lyme disease and, potentially other tick-borne infections.

PI_NAMEs: CRAFT, JOSEPH EDGAR;FIKRIG, EROL  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Animal Model;Animals;Antibody Response;Antigens;Black-legged Tick;Borrelia burgdorferi;Cavia;CD4 Positive T Lymphocytes;Complement;Data;Dermal;Development;experimental study;Exposure to;Fertility;Goals;Immune response;Immunization;Immunize;Immunologics;in vivo;Infection;Infection prevention;Integration Host Factors;Kinetics;Knowledge;Lead;lipid nanoparticle;Lyme Disease;Lyme Disease Vaccines;Lymphocyte Activation;lymphocyte proliferation;Messenger RNA;Modeling;Molting;nanoparticle;novel;novel vaccines;Oryctolagus cuniculus;pathogen;Pathway interactions;prevent;Prevention;Process;Proteins;Publishing;Reagent;Redness;Resistance;response;RNA Interference;RNA vaccination;Role;Saliva;saliva mediated;Salivary Proteins;Skin;Systemic infection;tick bite;tick saliva;tick transmission;Tick-Borne Infections;Ticks;transcriptome;transcriptomics;transmission process;Vaccination;vaccination strategy

PROJECT_TITLE: A novel Lyme disease vaccine

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Genetics

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE We will use random germline mutagenesis and a panel of 38 FACS and immunization screens to discover genes necessary for immune cell development and function. An advancement from the previous R01, this renewal application incorporates new computational tools that will improve our ability to identify causative mutations and to discover functional links between proteins, thereby delineating molecular pathways. We will also focus on understanding the mechanisms of several mutated genes linked to mRNA and tRNA regulation, vesicle trafficking and release, and transcription, which were previously unknown to function in immunity.

PI_NAMEs: BEUTLER, BRUCE A (contact)

PROJECT_TERMS: adaptive immune response;adaptive immunity;Affect;Alleles;Amino Acids;Antibody Response;B-Lymphocytes;Binding;Biological Assay;Candidate Disease Gene;Categories;causal variant;Cell Physiology;Cells;Code;Computer software;computerized tools;CRISPR/Cas technology;cytokine;Data;Databases;Defect;Development;Elements;Ethylnitrosourea;Etiology;Fingerprint;Flow Cytometry;Funding;gene discovery;gene product;Genes;genetic analysis;genetic pedigree;Genetic Screening;Genetic study;Genetic Transcription;Genome;Germ Lines;Germ-Line Mutation;Immune;immune function;Immune system;Immune System Diseases;Immunity;Immunization;immunodeficiency;Immunoglobulin M;Immunologics;Immunology;improved;Individual;Induced Mutation;insight;interest;Knock-out;Knowledge;Laboratories;Link;loss of function mutation;Lymphocyte;Lymphoid;Maps;Measurement;Measures;Meiosis;Messenger RNA;Metabolism;Molecular;Mus;Mutagenesis;Mutant Strains Mice;Mutate;Mutation;mutation screening;Names;Nonsense-Mediated Decay;novel;Paper;Pathway interactions;Patients;Phenotype;phenotypic data;Probability;Productivity;protein complex;protein folding;Proteins;Publications;Publishing;receptor;Recurrence;Regulation;Research Personnel;response;RNA Processing;RNA Splicing;Role;screening;Signal Transduction;Signaling Protein;Source;Supporting Cell;Surveys;Testing;Time;tool;trafficking;Transducers;Transfer RNA;Translations;Update;Validation;Vesicle;vesicle transport;Work;Writing

PROJECT_TITLE: Automated Forward Genetic Analysis of Adaptive Immunity

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]