NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health;Substance Misuse

PHR: Project Narrative Children and youth with perinatal exposure to HIV and antiretroviral medications (ARV) are at increased risk for cognitive, mental health and behavioral challenges, yet the underlying mechanisms of such risks are not well understood. The proposed research will leverage the Pediatric HIV/AIDS Cohort Study and large NIH-supported studies of normative development to identify the effects of perinatal HIV and ARV exposure on brain networks involved in cognitive and behavioral outcomes, such as emotional regulation and risk behaviors, using longitudinal structural and functioning neuroimaging along with cognitive and mental health measures. In light of the significant public health implications of the effects of HIV/ARV exposures throughout adolescence and young adulthood, this project will identify mechanisms driving cognitive, mental health and behavioral outcomes and will inform prevention and intervention strategies to support young people affected globally.

PI_NAMEs: WANG, LEI  (contact)

PROJECT_TERMS: Accounting;Address;Adolescence;Adolescent;adolescent substance use;Adult;Affect;Affective;Age;Anti-Retroviral Agents;antiretroviral therapy;Attenuated;attenuation;Automobile Driving;Behavior;Behavior assessment;Behavioral;behavioral outcome;Brain;brain abnormalities;Brain region;Breast Feeding;Cessation of life;Child;Childhood;Clinical;Cognition;Cognitive;cognitive function;cohort;Collaborations;Computers;congenital anomaly;connectome;Data;Development;Discrimination;Disease;early childhood;Education;efavirenz;emotion regulation;Emotional;emotional behavior;Emotions;Enrollment;Exhibits;experience;Exposure to;Family;Funding;Gender;General Population;Growth;HIV;HIV Infections;HIV/STD;Homelessness;Human;Impaired cognition;Impairment;Imprisonment;improved;in utero;Infection;Informal Social Control;Intervention;Investigation;Language;large scale data;Life;Light;Link;Measures;Mediating;Mediation;Mental disorders;Mental Health;Modeling;Monitor;Multicenter Studies;network dysfunction;Neurocognitive;neurodevelopment;neuroimaging;neuromechanism;neurotoxic;Outcome;Participant;Pediatric HIV/AIDS Cohort Study;pediatric human immunodeficiency virus infection;Perinatal;Perinatal Exposure;perinatal HIV;Personal Satisfaction;Persons;Pharmaceutical Preparations;poor communities;poor health outcome;Population;pregnant;prenatal;prenatal exposure;Prevention;Prevention strategy;protective factors;Protocols documentation;Psychopathology;Public Health;recruit;Regulation;Research;Rewards;Risk;Risk Behaviors;Risk Taking;Safety;Sampling;skill acquisition;skills;social;social factors;structural determinants;substance use;success;support network;surveillance study;Time;Toxic effect;United States National Institutes of Health;Unsafe Sex;Violence;Vocation;Woman;young adult;Youth

PROJECT_TITLE: TERBO BRAIN Study: Trajectories of Emotional Regulation and Behavior Outcomes and related Brain Regions And Intrinsic Networks


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PI_NAMEs: BERMAN, CLAIRE AMANDA (contact)

PROJECT_TERMS: Address;Adopted;Advocacy;Affect;Award;Awareness;Books;clinical research site;Collaborations;Communication;Communities;community advisory board;community engaged research;community engagement;Community Health Education;community involvement;Complex;contextual factors;Data;Data Analyses;Data Collection;Decision Making;design;Disclosure;Disease remission;Education;Education Projects;education resources;Effectiveness;Ensure;Equity;Ethics;Family;Feedback;Foundations;Funding;General Population;Goals;Health;health communication;Health education;Health Educators;HIV;HIV/AIDS;human subject protection;improved;Incubators;Individual;Informed Consent;Infrastructure;innovation;insight;interest;International;Joints;Knowledge;Leadership;Legitimacy;Lived experience;Longitudinal Studies;marginalization;marginalized community;marginalized population;Medical;member;Mentorship;Methodology;Modeling;multidisciplinary;novel;Participant;Pediatric HIV/AIDS Cohort Study;perinatal HIV;Persons;Phase;Politics;Population Intervention;pragmatic study;prevent;Procedures;Process;Program Research Project Grants;programs;Publishing;Quality of life;Recommendation;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;Research Proposals;Research Support;Resolution;Resources;Rights;Safety;Series;Services;social;Social Problems;social stigma;Structure;symposium;Translating;transmission process;United Nations;Validation;Voice;web portal;Woman;Work;Writing;young adult

PROJECT_TITLE: Health Education and Community Core (HECC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AARR-J]


ADMINISTERING_IC: CA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Radiation Oncology;Rare Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative: Current approaches to guiding percutaneous liver ablation have significant limitations yielding poor tumor control rates. This multi-disciplinary, multi-institutional Academic Industrial Partnership will develop and validate a simultaneous US and MR solution in combination with advanced MR methods for real-time guidance, treatment monitoring and margin assessment during liver ablations with the ultimate goal of improving patient outcomes.

PI_NAMEs: HOLMES, JAMES H (contact);WELLS, SHANE A;YEO, DESMOND TECK BENG

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: 3-Dimensional;3D ultrasound;Ablation;Acoustics;Adoption;Advanced Development;Algorithms;Anatomy;Animal Model;Animals;Breathing;Cattle;Cirrhosis;Clinical;clinical practice;Collaborations;comparative;Compensation;contrast enhanced;curative treatments;deep learning;Diffusion;Diffusion Magnetic Resonance Imaging;Elements;Equipment;Etiology;experimental study;Family suidae;Feedback;flexibility;Fluoroscopy;Freedom;Goals;Hand;Human;Image;image guided;image guided intervention;image guided radiation therapy;image registration;improved;in vivo imaging system;industry partner;innovation;Institution;Intervention;Interventional Ultrasonography;Intestines;Iowa;Lesion;Liver;liver ablation;liver tumor ablation;Location;Lung;Magnetic Resonance Imaging;Methods;microwave ablation;microwave electromagnetic radiation;minimally invasive;Modality;Modeling;Monitor;Motion;multidisciplinary;Navigation System;Needles;novel;operation;Operative Surgical Procedures;Organ;Pathology;Patient-Focused Outcomes;Patients;Performance;Perfusion;Positioning Attribute;pre-clinical;Procedures;real-time images;Recurrence;Research;respiratory;Roentgen Rays;Safety;Scientist;Site;skills;soft tissue;success;Sum;System;Techniques;Technology;technology validation;Temperature;temporal measurement;Thermometry;Time;Tissue Model;Tissues;Translating;treatment response;tumor;Ultrasonography;ultrasound;United States National Institutes of Health;Universities;user-friendly;Validation;virtual;Wisconsin;Work;X-Ray Computed Tomography

PROJECT_TITLE: Simultaneous MRI/US for real-time liver ablation guidance and confirmation


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

PI_NAMEs: PATEL, KUNJAL  (contact)

PROJECT_TERMS: Acceleration;Address;Adolescent;Adult;Advanced Development;analytical method;analytical tool;behavioral outcome;Bioinformatics;Birth;Brain region;career;case control;Child;Childhood;Clinic;Clinical;Cognitive;cohort;Collaborations;Complex;Conceptions;Continuing Education;Correlation Studies;Data;Data Analyses;data resource;Databases;deep learning algorithm;design;Development;Disease remission;E-learning;Education;Effectiveness;emotion regulation;emotional behavior;Environment;Epidemiologic Methods;Epidemiologist;Epidemiology;Epigenetic Process;Evaluation;Evaluation Studies;Faculty;Formulation;Fostering;Genes;Genetic;Genomics;Goals;Graph;Gynecologist;Health;health determinants;Hearing;high dimensionality;HIV;Image;Immunologist;in utero;Individual;Informatics;informatics tool;innovation;interest;Language;life span;longitudinal design;Measurement;Mediation;Mediator;Mental Health;Mentorship;Methodology;Methods;microbiome;Modification;Monitor;Mothers;multidisciplinary;multilevel analysis;Nature;neuroimaging;Neurologist;novel;Observational Study;Oral health;Outcome;Outcome Study;Parameter Estimation;Pediatric epidemiology;Pediatric HIV/AIDS Cohort Study;pediatric human immunodeficiency virus;pediatrician;Perinatal;Perinatal Epidemiology;perinatal HIV;Persons;Population Intervention;Population Study;Pregnancy;prevent;Probability;Program Research Project Grants;programs;prospective;Protocols documentation;Research;Research Design;Research Personnel;Research Project Grants;Resources;Risk;Safety;Sampling;Scheme;Series;Site;social;Social outcome;Source;Specialist;Specific qualifier value;Statistical Methods;statistical service;Time;tool;Toxic effect;Training;transmission process;Weight;young adult;Youth

PROJECT_TITLE: Epidemiological and Statistical Methods Core (ESC)


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Dietary Supplements;Genetics;Microbiome;Neurosciences;Nutrition;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Traumatic brain injury afflicts approximately three million Americans every year with a high rate of long-term cognitive and psychiatric morbidity. Chronic neuroinflammation resulting from the constitutive activation of microglia is complicit in this process and represents a complex interplay between the injured brain, microglia, and the gut microbiome via the gut-brain axis. However, the mechanism(s) underlying gut microbiota-microglia interaction have yet to be elucidated.

PI_NAMEs: SCHWULST, STEVEN J (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acetates;Alleles;Alzheimer's Disease;American;Anaerobic Bacteria;Anatomy;apolipoprotein E-4;Attenuated;Bacteria;behavioral phenotyping;biomarker development;Biota;Brain;brain cell;Brain Injuries;Butyrates;C57BL/6 Mouse;Candidate Disease Gene;Cause of Death;Cell Separation;Cessation of life;Chronic;Clinical Trials;Clostridium;Cognitive;cohort;Communities;Complex;Data;Death Rate;Development;Dietary Fatty Acid;Dietary Fiber;Dietary Intervention;Dietary Supplementation;disability;Disease;drinking water;experimental study;fecal transplantation;Feces;Fermentation;Fluorine;Gene Expression Profile;Generations;Genetic;genetic risk factor;genetic variant;Genotype;Germ-Free;glial activation;gut microbiome;gut microbiota;gut-brain axis;Health Expenditures;Histopathology;Immune;improved;Injury;Intervention;Laboratories;Lesion;Link;Magnetic Resonance Imaging;Measures;Metabolic;metabolomics;microbial;microbiome composition;microbiota;Microglia;Molecular Profiling;Morbidity - disease rate;mouse model;Mus;Nervous System Disorder;Nervous System Trauma;Neurocognitive;Neurocognitive Deficit;Neurodegenerative Disorders;neuroinflammation;novel;novel therapeutics;Outcome;Outcome Measure;Parkinson Disease;Pathologic;PET/CT scan;Population;post stroke;Process;Propionates;Proteins;Publishing;radiotracer;reconstitution;response;RNA, Ribosomal, 16S;rRNA Genes;Shapes;single-cell RNA sequencing;Structure;Survivors;Symptoms;TBI Patients;Testing;therapeutic development;transcriptomics;Translating;translational potential;Trauma;Traumatic Brain Injury;United States;Variant;Veins;Volatile Fatty Acids;X-Ray Computed Tomography;young adult

PROJECT_TITLE: Trauma, the gut, and the brain: the gut microbiota-microglia axis in traumatic brain injury

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAN JUAN

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PUERTO RICO RIO PIEDRAS

ORG_STATE: PR

PHR: Narrative The NeuroGRAD program will be the first Neuroscience graduate training program of its kind at the University of Puerto Rico, a premier research-intensive Hispanic Serving Institution in the USA. The main goal of NeuroGRAD program is to successfully impact, educate, train, and develop the new generation of promising underrepresented minority (URM) neuroscience graduate students using evidence-based successful strategies founded on three key strands: (1) the development of impactful neuroscience training blueprint based on cutting- edge and hands-on research experiences (2) the establishment of an effective multilayered mentoring network through strong partnerships with top-notch neuroscience researchers in Research 1(R1) institutions in the mainland and (3) the design of a series of transformative skill set activities that will yield a new cohort of URM neuroscientists role models and leaders in the 21st Century Neuroscience workforce.

PI_NAMEs: MALDONADO-VLAAR, CARMEN SARA (contact)

PROGRAM_OFFICER_NAME: JONES, MICHELLE

PROJECT_TERMS: Area;aspirate;Awareness;Capital;career;Career Choice;Central Nervous System;cohort;Collaborations;Communication;community building;Competence;Custom;design;Development;Development Plans;diversity and inclusion;Doctor of Philosophy;Educational workshop;Eligibility Determination;Ensure;Environment;Equipment;evidence base;experience;Exposure to;Face;Fostering;Future;Generations;Goals;Graduate Degree;graduate student;Growth;hands on research;Hispanic-serving Institution;Home;improved;Influentials;innovation;Institution;inter-institutional;interest;Internships;Laboratories;Lead;Leadership;Learning;Link;medical schools;meetings;member;Mentors;minority communities;Mission;Monitor;Neurosciences;Neurosciences Research;notch protein;novel;Participant;Positioning Attribute;Postdoctoral Fellow;programs;Public Speaking;Puerto Rico;Research;Research Activity;Research Personnel;Research Project Grants;research to practice;Research Training;resilience;Resources;role model;Science;Scientist;Self Efficacy;Series;skill acquisition;skills;Solid;student training;Students;Supervision;symposium;Techniques;tool;Training;Training Activity;Training Programs;Travel;Underrepresented Minority;underrepresented minority student;Universities;virtual platform;Visit;Work

PROJECT_TITLE: NeuroGRAD@UPR- Neuroscience Graduate, Resilience, Affirmation and Diversity Program at the University of Puerto Rico


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Machine Learning and Artificial Intelligence;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE: CAR based immunotherapies are now credentialed as potent tools against hematologic malignancies and early signals suggest that these therapeutics may prove beneficial against brain tumors. Building upon impressive results in preclinical models, this project will undertake a Phase I trial of GD2-CAR T cells in H3K27M diffuse midline gliomas, universally lethal tumors of childhood and young adults. The project seeks to ensure the safety of this therapy for patients with brainstem gliomas where the risk of toxicity due to tumor edema is high, will use novel approaches to measure clinical efficacy and seek to define biomarkers or response, and will undertake studies focused on interrogating the biology of myeloid cell activation following CNS directed CAR T cell therapies that has been observed both in preclinical and clinical studies.

PI_NAMEs: MACKALL, CRYSTAL  (contact);MONJE-DEISSEROTH, MICHELLE

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Adverse event;aged;Algorithms;Animal Testing;Animals;Antigens;antitumor effect;Antitumor Response;B lymphoid malignancy;bench to bedside;bench-to-bedside translation;Biological Markers;Biology;biomarker identification;Biometry;Brain Neoplasms;Brain Stem Glioma;Brain Stem Neoplasms;Cancer Etiology;cancer immunotherapy;CAR T cell therapy;CD47 gene;cell free DNA;Cells;Cessation of life;Characteristics;Child;Childhood;Childhood Brain Neoplasm;childhood cancer mortality;Childhood Malignant Brain Tumor;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical efficacy;Clinical Management;Clinical Research;cohort;Coin;Collaborations;Credentialing;cytokine;Data;design;Diffuse intrinsic pontine glioma;diffuse midline glioma;Disease;Dose;Dose Limiting;Edema;Eligibility Determination;Engineering;Enrollment;Ensure;Event;Exhibits;experience;Ganglioside GD2;Glean;Hematologic Neoplasms;Histones;Human;Hydrocephalus;Image;Immunotherapy;improved;improved outcome;Inflammation;insight;Institution;Intracranial Hypertension;Intracranial Pressure;intravenous administration;Machine Learning;machine learning algorithm;Macrophage;Magnetic Resonance Imaging;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mediating;Monitor;mouse model;Mus;mutant;Mutate;Myelogenous;Myeloid Cell Activation;Myeloid Cells;neuro-oncology;Neuroblastoma;neurosurgery;neurotoxicity;novel;novel strategies;Outcome;overexpression;participant enrollment;participant safety;Patient-Focused Outcomes;Patients;Pediatric Neoplasm;Phase;Phase I Clinical Trials;phase I trial;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Progression-Free Survivals;Radiation therapy;radiological imaging;radiomics;Recommendation;Regimen;Reporting;Research Personnel;resistance mechanism;response;Risk;Safety;safety assessment;Signal Transduction;single cell analysis;Solid Neoplasm;Spinal;Spinal Cord;Standardization;Supportive care;Survival Rate;Swelling;T-Lymphocyte;Testing;Texture;Therapeutic;tool;Toxic effect;Translating;Translations;Treatment Efficacy;trial design;tumor;tumor DNA;tumor immunology;Xenograft Model;young adult

PROJECT_TITLE: Developing Safe and Effective GD2-CAR T Cell Therapy for Diffuse Midline Gliomas

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Narrative The proposed research is a systems biology approach to characterize the genetic and regulatory underpinnings of antibiotic persistence in the bacterium E. coli. The proposed studies will provide critical insights into how small sub-population of bacteria become tolerant to otherwise lethal levels of antibiotics. This phenomenon is highly relevant to emerging health crisis of antibiotic tolerance.

PI_NAMEs: TAVAZOIE, SAEED F (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Address;Affect;anti-toxin;antibiotic tolerance;Antibiotics;Atlases;Bacteria;Bacterial Genes;Bacterial Infections;biological systems;Cells;Chemicals;Chromosome Mapping;Chronic;Clinical;clinically significant;Complex;CRISPR interference;density;Development;DNA;efficacy validation;Escherichia coli;Event;Evolution;Foundations;Frequencies;Funding;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;Growth;Health;Heterogeneity;high throughput technology;in vivo;Infection;insight;knock-down;Maps;Microbial Biofilms;Modeling;Molecular;Monitor;Morphologic artifacts;Pathway interactions;Phase;Phase Transition;phenomenological models;Phenotype;Physiological;Physiology;Population;Process;Protein Analysis;Proteins;Research;Research Personnel;Resolution;RNA;Role;Sampling;single-cell RNA sequencing;System;Systems Biology;Technology;temporal measurement;therapeutic development;Time;Toxin;transcriptome;Transfer RNA;Work

PROJECT_TITLE: Systems biological interrogation of bacterial persistence

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: Columbus

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Reduced B55 α expression frequently occur in ovarian cancers. The goal of this application is to explore new approaches to treat B55 α-defective ovarian cancers by studying a new synthetic lethal interaction between B55 α deficiency and cell cycle checkpoint kinases inhibition. If successful, our study will have a significant impact on improving the survival of ovarian cancer patients by identifying new approaches for treating B55 α defective ovarian cancer and by providing a new stratification biomarker for identifying ATR/CHK1 inhibitor sensitive populations.

PI_NAMEs: ZHANG, JUNRAN  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: ataxia telangiectasia mutated protein;Binding;biological adaptation to stress;Biological Assay;Biological Markers;biomarker identification;c-myc Genes;cancer cell;Cancer Etiology;Cancer Patient;Cell Line;Cell Physiology;Cell Survival;Cells;CHEK1 gene;Chromosome Fragile Sites;Clinic;Clinical Trials;Data;Dependence;Development;Disease;DNA biosynthesis;DNA Damage;Epithelial ovarian cancer;Event;Exhibits;genome-wide;Goals;Immune checkpoint inhibitor;improved;inhibitor;loss of function;Loss of Heterozygosity;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Molecular;mutant;Mutate;Mutation;Normal Cell;Normal tissue morphology;novel;novel marker;novel strategies;novel therapeutic intervention;Oncogene Activation;Oncogenes;Oncogenic;Pathway interactions;patient derived xenograft model;patient population;patient stratification;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Population;predicting response;Production;Protein phosphatase;Reactive Oxygen Species;Regulation;Replication Initiation;replication stress;Reporting;response;Role;scaffold;Serine;Serous;Signal Transduction;Source;Stratification;Stress;Survival Rate;synthetic lethal interaction;targeted treatment;Testing;therapeutic target;therapy resistant;Threonine;Toxic effect;treatment strategy;tumor;tumor growth;whole genome;Woman;Women's mortality;Xenograft procedure

PROJECT_TITLE: B55 alpha deficiency as a therapeutic target in cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Aging;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: COLLEGE STATION

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: Project Narrative Our long-term goal is to identify strategies that can acutely enhance the astrocytic scar, thereby reducing cell death and inflammation at the injury site, and promoting functional recovery in the newly spinally-injured aging population. The overall objective of this project is to demonstrate that enhancing mitochondrial functions in astrocytes early after SCI will enhance astroglial scar formation, and functional recovery after SCI in aged animals. Our central hypothesis is that the age-dependent decline in astrocytic mitochondrial functions impairs astroglial scar formation and reduces functional recovery after SCI with age.

PI_NAMEs: GEOFFROY, CEDRIC G (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;Age;age related;age related changes;age related decline;aged;Aging;aging population;animal old age;Astrocytes;astrogliosis;Biological;Biological Assay;Biology;Biology of Aging;Cell Death;cell type;Cells;Chronic;Cicatrix;Data;FDA approved;Fractionation;functional decline;gain of function;Genetic;Genetic Transcription;Goals;Histocytochemistry;Impairment;improved;In Vitro;in vivo;Inflammation;inflammatory marker;Injections;Injury;Lesion;loss of function;Measures;Mediating;Mediator;Membrane Potentials;middle age;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Molecular;Molecular Biology;mRNA delivery;mRNA Expression;Mus;neural;Neurons;neuroprotection;normal aging;Nuclear;old mice;overexpression;Oxidative Phosphorylation;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Phosphorylation;PIAS3 Gene;Play;Population;pre-clinical therapy;Recovery;Recovery of Function;Reporting;response to injury;Role;Signal Transduction;Site;Sorting;Spinal;Spinal cord injury;Spinal Injections;Spinal Injuries;STAT protein;STAT3 gene;System;Testing;Tissues;Transgenic Mice;Translating;United States;Western Blotting;Work

PROJECT_TITLE: Understanding the age-dependent mitochondrial function in astrocytes after spinal cord injury via bi-directional manipulation of activity

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Cancer

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE The growing quest to understand the dynamics of intracellular and inter-cellular metabolism in the tumor microenvironment demands improved and expanded analytical techniques from specialized cores. I propose to build on the unique suite of services I have developed as Director of the Cancer Metabolism Core in the Cancer Center at Sanford Burnham Prebys Medical Discovery Institute (SBP). Funding from an R50 award will support my goal to build a comprehensive, state-of-the-art, innovative and collaborative Cancer Metabolism Core at SBP.

PI_NAMEs: SCOTT, DAVID ANDERSON (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: anti-cancer research;Award;Bile Acids;Biological Assay;cancer cell;Cancer Center;cancer research center director;Cell Separation;Chemicals;Cholesterol;Derivation procedure;detection sensitivity;Development;Fatty Acids;Funding;Goals;Grant;Hexosamines;improved;innovation;Interdisciplinary Study;ionization;Mass Fragmentography;Measures;Medical;Metabolic;Metabolism;metabolomics;Methods;NCI-Designated Cancer Center;Organelles;Paper;Pathway interactions;Population;Positioning Attribute;Protocols documentation;Quality Control;Request for Proposals;Research;Services;stable isotope;sugar;Sugar Phosphates;Techniques;Technology;Tracer;tumor;tumor metabolism;tumor microenvironment;Work

PROJECT_TITLE: Development and Implementation of Advanced Technologies for Cancer Metabolism Research


NIH_SPENDING_CATS: Breast Cancer;Cancer;Nutrition;Women's Health Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE This proposal investigates the contribution of the essential nutrient, copper, to the growth and spread of cancer cells by testing novel compounds that interfere with the delivery and use of copper by cancer cells.

PI_NAMEs: PETRIS, MICHAEL J. (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: 4T1;absorption;Address;Affinity;analog;Animal Model;anti-cancer;Artificial Membranes;Binding;Binding Sites;Biological;Biological Assay;Biological Availability;Biological Markers;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Caco-2 Cells;cancer cell;Cancer cell line;Cancer Model;Cancer Patient;cancer therapy;Cell Membrane Permeability;cell motility;Ceruloplasmin;Chelating Agents;chelation;Clinical;Clinical Research;Clinical Trials;Computer Assisted;Copper;design;Detection;Development;Diet;Disease Progression;Dose;Drug Design;Drug Kinetics;Enzymes;ERBB2 gene;Evaluation;experimental study;Family;functional group;Goals;Growth;high risk population;Hot Spot;human model;improved;In Vitro;inhibitor;innovation;Intestines;Lead;lead optimization;Liver Microsomes;lung cancer cell;Malignant Breast Neoplasm;Malignant Neoplasms;MAP2K1 gene;Maximum Tolerated Dose;Mesothelioma;Metabolic;Metabolism;Metastatic breast cancer;Micronutrients;Modeling;Molecular Conformation;Monitor;Mouse Mammary Tumor Virus;mouse model;Mus;nanomolar;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel;novel therapeutic intervention;Nutrient;Oncogenic;Oral;oxidation;Pathway interactions;Patients;Performance;Permeability;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phosphotransferases;Pre-Clinical Model;preclinical development;Predisposition;Primary Neoplasm;Process;Property;Protein-Lysine 6-Oxidase;Proteins;Publishing;Role;screening;Serum;small molecule;small molecule inhibitor;Structure;Structure-Activity Relationship;Testing;Therapeutic;therapeutic target;therapy development;Time;Tissues;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;tumor growth;validation studies

PROJECT_TITLE: Targeting vulnerabilities in copper metabolism in the development of cancer therapies

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Arthritis;Hematology;Pediatric

ORG_CITY: SEATTLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Macrophage activation syndrome (MAS) is a serious and potentially fatal complication of rheumatic disease or viral infection. MAS is characterized by the development of cytopenias and the accumulation of hemophagocytes— activated macrophages that phagocytose red blood cells. The goal of this project is to define the mechanisms that drive the development of hemophagocytes and disease in MAS.

PI_NAMEs: THULIN, NATALIE K (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Ablation;Acute;Address;Agonist;Anemia;ATAC-seq;Automobile Driving;Cessation of life;Characteristics;Chronic;Complication;cytokine;cytokine release syndrome;cytopenia;Data;Development;differentiation in vitro;Disease;Dose;Education;effective therapy;Emergency Situation;Endosomes;Erythrocytes;experimental study;Faculty;Family;Genes;Genetic Predisposition to Disease;Goals;Heme;Hemophagocytic Lymphohistiocytoses;Human;human disease;Immunosuppression;In Vitro;in vitro Assay;in vivo;inducible gene expression;Infection;Inflammation;Inflammatory;Innate Immune Response;insight;Institution;Interferon Type I;Interferons;Intermittent Pyrexia;Macrophage;Macrophage activation syndrome;Mediating;member;Modeling;monocyte;mouse model;Multiple Organ Failure;Mus;Myelopoiesis;Natural Immunity;novel;overexpression;Patients;Phagocytes;Phagocytosis;Phenotype;Population;Production;receptor;Red Blood Cell Count;Research;Research Personnel;Rheumatism;RNA;Role;sensor;Signal Transduction;Symptoms;synergism;systemic juvenile idiopathic arthritis;Systemic Lupus Erythematosus;Thrombocytopenia;TLR7 gene;Training;transcription factor;transcriptome sequencing;Virus Diseases;Work

PROJECT_TITLE: Defining signals contributing to inflammatory hemophagocyte differentiation in TLR7 mediated Macrophage Activation Syndrome


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: JACKSON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Alcohol’s ability to enhance the activity of -aminobutyric acid (GABA) at GABAA receptors has been implicated as a key mechanism underlying the abuse-related effects of alcohol in humans, making this system an attractive candidate for the development of therapeutics. The complex molecular biology of GABAA receptors raises the possibility that subtype-selective drugs can be developed with therapeutic specificity against alcohol use disorders. Our studies will yield needed information about neuropharmacological mechanisms underlying the addictive effects of alcohol and begin to identify clinical scenarios in which specific pharmacological approaches might be expected to produce improved patient outcomes.

PI_NAMEs: PLATT, DONNA M (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Agonist;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol relapse;alcohol seeking behavior;alcohol use disorder;Alcohols;Aminobutyric Acids;Attenuated;Behavior;Behavior Therapy;Behavioral;Benzodiazepines;Clinic;Clinical;Combined Modality Therapy;Complex;contingency management;craving;Cues;Data;deprivation;Development;Diazepam;Dose;drinking;Exhibits;FDA approved;GABA-A Receptor;gamma-Aminobutyric Acid;Goals;Human;human subject;improved;Laboratories;Laboratory Animals;Learning;Ligands;Literature;Mediating;Mediator;medication-assisted treatment;Methods;Modeling;Molecular Biology;Monkeys;motor behavior;Naltrexone;Neurobiology;Neurons;non-drug;nonhuman primate;novel;Observational Study;Oral;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;Play;Population;pre-clinical;Primates;Procedures;Rattus;receptor;reinforcer;Relapse;Research;Research Personnel;Rodent;Rodent Model;Role;Self Administration;side effect;Specificity;Stimulus;Sucrose;System;Therapeutic;therapeutic development;Training;treatment strategy

PROJECT_TITLE: GABA-A receptor subtype mechanisms and the abuse-related effects of alcohol

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Diabetes;Immunotherapy;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Cell replacement therapy is a potential cure for T1D but must overcome major challenges of islet supply and immune protection. We developed a novel technology to direct cultured human stomach progenitors derived from biopsies to generate abundant insulin-secreting Beta-like cells capable of long-term glycemic control. We propose to significantly improve the progenitor lines and derivation protocol to enable consistent production of functional and immune-evasive autologous grafts for a cell replacement approach without immune suppression or encapsulation.

PI_NAMEs: RAFII, SHAHIN  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Adoption;age group;Anterior;Antigens;Attenuated;Autoantigens;Autoimmune;Autoimmune Responses;Autologous;Autologous Transplantation;Beta Cell;Biological Assay;Biological Response Modifiers;Biopsy;Biopsy Specimen;CD47 gene;CD8-Positive T-Lymphocytes;Cell Communication;Cell Line;cell replacement therapy;Cell Therapy;cell type;Cells;Cellular Assay;clinical translation;Clone Cells;constitutive expression;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Derivation procedure;Diabetes Mellitus;diabetic;Doxycycline;Encapsulated;Engineering;eye chamber;Future;G6PC2 gene;gastric organoids;gastrointestinal;Generations;Genetic;Glucose;glucose monitor;Glucose tolerance test;glycemic control;Human;Immune;Immune Evasion;immunogenic;Immunosuppression;improved;In Vitro;in vivo;in vivo imaging;Innate Immune Response;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;insulitis;islet;Islets of Langerhans Transplantation;Knock-in;Laboratories;Methods;Molecular;Mus;Names;new technology;NPM1 gene;Organoids;Persons;Physiologic pulse;preproinsulin;Production;progenitor;programmed cell death ligand 1;Proliferating;Protocols documentation;single-cell RNA sequencing;Stains;Standardization;stem cells;Stomach;Structure of beta Cell of islet;T-Lymphocyte;Technology;Tissue Donors;Tissue Grafts;Tissues;translational potential;Transplantation;tumor;Variant

PROJECT_TITLE: Engineering islet-like organoids from gastric stem cells for T1D cell replacement therapy


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: Narrative Glioblastomas are the most common malignant primary brain tumor, afflicting approximately 13,000 adults in the United States every year. The most effective treatments are radiation and a chemotherapy called temozolomide or lomustine but quickly become resistant and are fatal as a result. This proposal aims to determine how glioblastomas become resistant to radiation and temozolomide by determining the genetic changes they undergo during treatment, thereby enabling us to devise more effective treatment strategies.

PI_NAMEs: BEROUKHIM, RAMEEN  (contact);CHAKRAVARTI, ARNAB ;LIGON, KEITH LLOYD

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Ablation;Address;Adult;Alkylating Agents;Alkylation;Amino Acids;biobank;Biological Assay;Biological Markers;biomarker driven;cancer survival;Carmustine;cell free DNA;Characteristics;checkpoint inhibition;checkpoint therapy;CHEK1 gene;chemotherapy;clinical biomarkers;clinical implementation;clinical practice;Clinical Trials;Clonality;Collection;Combined Modality Therapy;crosslink;Data;Defect;Development;DNA Damage;DNA Interstrand Crosslinking;DNA Repair;effective therapy;Effectiveness;Evaluation;Evolution;experimental study;functional genomics;Generations;Genes;Genome;genome integrity;Genomics;Glioblastoma;Glioma;Grant;Guanine;Human;Immune response;Immunotherapy;improved;improved outcome;in vitro Model;in vivo;Induced Mutation;inhibitor;innovation;interest;Knowledge;Lesion;Light;Lomustine;Malignant - descriptor;Malignant Glioma;Malignant Neoplasms;Mediating;Methylation;MGMT gene;Mismatch Repair;Mismatch Repair Deficiency;Modeling;Modernization;Molecular;mouse model;mutant;Mutation;neoantigens;New Agents;Nitrosourea Compounds;novel;novel therapeutic intervention;Pathway interactions;Patient Monitoring;Patients;PD-1/PD-L1;PDL1 inhibitors;phase III trial;Plasma Cells;predicting response;prevent;Primary Brain Neoplasms;Proliferating;promoter;Proteins;Radiation;Radiation induced damage;Radiation Tolerance;radioresistant;repaired;Research;Resistance;resistance mechanism;response;Role;Shapes;Source;targeted agent;targeted treatment;Technology;temozolomide;Testing;Therapeutic;therapeutic target;Tissues;Toxic effect;treatment strategy;tumor;United States;Work

PROJECT_TITLE: Evolution of gliomas during treatment and resistance

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Bioengineering;Brain Disorders;Nanotechnology;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE / RELEVANCE The proposed research seeks to identify environmental risk factors for amyotrophic lateral sclerosis (ALS) using the ALS population in Massachusetts, the only state in the United States with a reportable ALS registry. Our hypothesis is that the presence, concentration, combination and/or spatial distribution of persistent and toxic elements (e.g. trace elements and nanoparticles) is associated with ALS risk.

PI_NAMEs: STOMMEL, ELIJAH W (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Age;ALS patients;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Autopsy;brain tissue;case control;Case/Control Studies;cell type;Central Nervous System;Cessation of life;Characteristics;Chemicals;Clinical;Clinical Research;comparison control;Country;Data;Databases;Development;Diagnosis;Disease;disorder risk;drinking water;Early Diagnosis;Elements;Environmental Exposure;Environmental Pollutants;Environmental Risk Factor;epidemiology study;Etiology;Evaluation;Exhibits;experience;Exposure to;frontal lobe;Frontotemporal Dementia;Future;Genetic Predisposition to Disease;Geographic Information Systems;Human;Inductively Coupled Plasma Mass Spectrometry;insight;Investigation;Lead;Light;Link;Location;Manganese;Maps;Massachusetts;Measurement;Measures;Mercury;Methodology;Methods;Monozygotic twins;Motor Neuron Disease;Motor Neurons;nanoparticle;Nerve Degeneration;Neurodegenerative Disorders;neurotoxicity;Neurotoxins;novel;Occupations;Parkinson Disease;Participant;Pathogenicity;Pathologic;patient registry;Patients;Peripheral;Physiological;Population;prevent;Prevention;Recording of previous events;Registries;Reporting;Research;residence;Risk;Risk Factors;Sampling;sex;Shapes;Spatial Distribution;spatiotemporal;Symptoms;targeted treatment;Techniques;Testing;Therapeutic;time interval;Tissues;Toxic effect;Toxicant exposure;Toxicology;Trace Elements;Transmission Electron Microscopy;United States;Work;X ray spectroscopy

PROJECT_TITLE: Investigating Toxic Elements and Nanoparticles in ALS Etiology: A Geospatial and Toxicological Evaluation of Massachusetts ALS Registry Patients


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: PASADENA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: NARRATIVE To study biological systems in their critical in vivo context and develop effective cell-based therapies, we need new methods to manipulate the function of cells deep inside living animals. In this project we will develop a technology that enables cellular remote control with ultrasound – a form of energy that can be targeted non- invasively to deep tissues with sub-millimeter spatial precision. This technology will use genetically encoded “acoustic antennae” to convert ultrasound into local mechanical force and apply it to engineered mechanosensitive receptors, triggering desired cellular pathways for remote-control of neural activity and immunotherapy.

PI_NAMEs: SHAPIRO, MIKHAIL  (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Acoustics;Anatomy;Animals;Biological;Biological Phenomena;biological systems;Biology;Biosensor;Brain region;Cell Physiology;Cell Therapy;Cells;cellular imaging;Communication;Deposition;Development;Engineering;Fluorescence Microscopy;Focused Ultrasound;Gastrointestinal tract structure;Gene Expression;Goals;Human body;Image;Immune;immune cell infiltrate;Immunotherapy;in vivo;Investigation;Light;Location;mechanical force;Mechanics;Medical Imaging;Medical Technology;meter;Methods;microbial colonization;millimeter;Modality;molecular imaging;Neurons;neuroregulation;Neurosciences;neurotransmission;Operative Surgical Procedures;Optics;optogenetics;Pathway interactions;Penetration;Physics;Process;Property;Proteins;receptor;remote control;Reporter Genes;Research;Research Personnel;Signal Transduction;sound;Structure;Techniques;Technology;Tissues;tool;Travel;tumor;ultrasound;Visible Radiation;Visualization;Work

PROJECT_TITLE: Sonogenetic Remote Control of Cellular Function


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative—Health Relevance This project will identify pharmacological interventions that improve the length of life and/or the quality of aging in a simple animal model that shares many hallmark features of aging in humans. Data obtained at three assay sites by rigorously testing a genetically diverse test set is anticipated to identify chemical treatments with high potential to be efficacious in a diverse human population. Our study may lead to treatments that protect against physical deterioration, cognitive decline, and disease susceptibility in the elderly human population.

PI_NAMEs: PHILLIPS, PATRICK C. (contact)

PROGRAM_OFFICER_NAME: FOX, JENNIFER THERESA

PROJECT_TERMS: Acceleration;Age;age-related disease;Aging;aging process;American;Animal Model;Biological Assay;Biological Models;Biology of Aging;Caenorhabditis;Caenorhabditis elegans;Caregivers;Chemicals;Chronic Disease;Chronology;Clinical Research;Clinical Sciences;Collection;Communities;community setting;Data;Data Set;Databases;Death Rate;Dementia;design;Deterioration;Diabetes Mellitus;Disease;Disease susceptibility;Economics;efficacy testing;Elderly;extend lifespan;Gene Expression Regulation;Genes;Genetic;Genetic Drift;Genetic Heterogeneity;genome editing;Goals;Health;Healthcare Systems;healthspan;healthy aging;Heart;Heterogeneity;Human;human old age (65+);Impaired cognition;improved;Individual;innovation;Intervention;Laboratories;late life;Life;life span;Link;Longevity;Malignant Neoplasms;Mammalian Genetics;Maps;Medical Research;Molecular;mortality;mouse model;Mus;Nematoda;Neurodegenerative Disorders;novel;Oregon;Outcome;Pathway interactions;Pattern;pharmacologic;Population;Population Heterogeneity;pre-clinical;pre-clinical research;Privatization;Process;programs;Quality of life;rate of aging;Recommendation;Reporting;Reproducibility;Research;Resistance;Resolution;Risk Factors;Science;screening;Site;Societies;Statistical Models;Stress;success;System;Systems Analysis;temporal measurement;Testing;therapy development;transcriptome sequencing;Translating;Translations;Validation;Variant;Virus Diseases;whole genome;Work

PROJECT_TITLE: Caenorhabditis Intervention Testing Program at Oregon


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE  Deaths of older adults with Alzheimer's disease and Alzheimer's Disease-related dementias (AD/ADRD) are common and fast growing, while end-of-life care for AD/ADRD patients is often overly aggressive and costly. Advance care planning (ACP), the discussion of patient preferences and goals of care in the event of patient losing decision-making capacity, holds promise in curbing overly aggressive EOL care for AD/ADRD patients. This project aims to evaluate the effect of two recent Medicare reimbursement policy changes that promote ACP practice, providing rigorous and critical evidence for improving EOL care among AD/ADRD patients.

PI_NAMEs: LI, JING  (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Admission activity;Advance Care Planning;aggressive therapy;aging population;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Atlases;care providers;career;Caring;Cause of Death;Cessation of life;Characteristics;Code;cognitive testing;Communication;Community Surveys;comorbidity;Comprehensive Health Care;cost;Data;Data Sources;decision-making capacity;dementia care;demographics;design;Development;end of life;end of life care;Enteral Feeding;Event;experience;Funding;Geriatrics;Goals;Health;Health Personnel;Health Policy;Healthcare;Hospice Care;hospice utilization;Hospitalization;Hospitals;Impaired cognition;improved;Individual;innovation;instrument;Intensive Care Units;Life;Logistic Regressions;Measures;medical specialties;Medicare;Medicare claim;Neighborhoods;Nursing Homes;older adult;Older Population;Palliative Care;Patient Preferences;Patients;Physicians;Policies;Policy Analysis;Probability;Procedures;Process;Provider;Quality Indicator;Quality of Care;Quality of life;Quasi-experiment;Research;Research Design;Research Methodology;Research Personnel;Residencies;Services;socioeconomics;statistical learning;Techniques;Training;Writing

PROJECT_TITLE: Effect of Medicare Reimbursement for Care Planning on End of Life Care among Patients with Alzheimer's Disease and Related Dementias: A Quasi-Experimental Study

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Liver Disease;Sarcopenia;Substance Misuse

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Despite the high clinical significance of alcoholic hepatitis (AH), targeting hepatic injury alone has been of limited therapeutic benefit. Loss of muscle mass or sarcopenia is frequent and adversely affects clinical outcomes in AH. We propose to use a specific molecular weight hyaluronan, HA35, to restore skeletal muscle protein homeostasis and improve outcomes in AH. We will ascertain whether HA35 protects against ethanol-induced tissue injury in healthy subjects and patients with moderate AH.

PI_NAMEs: DASARATHY, SRINIVASAN  (contact);NAGY, LAURA E.

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Acute;Affect;alcohol effect;alcohol exposure;alcohol response;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Ammonia;Autophagocytosis;Binding;CD14 Antigen;CD44 Antigens;CD44 gene;Cell Culture Techniques;Chronic;circulating biomarkers;Clinical;clinical application;Clinical Trials;clinically significant;Data;Data Coordinating Center;Development;Diameter;Endotoxemia;Ethanol;Ethanol Metabolism;Food Supplements;Funding;gain of function;gastrointestinal epithelium;GDF8 gene;Genetic Transcription;Goals;Hepatic;hepatic ureagenesis;Hepatocyte;hepatocyte injury;Hepatotoxicity;Human;human subject;Hyaluronan;Hyaluronic Acid;Hyperammonemia;Impairment;improved;improved outcome;In Vitro;in vivo;Inflammation;Inflammatory Response;Injury;innovation;intestinal epithelium;Knowledge;Kupffer Cells;Life;Lipopolysaccharides;Liver;Liver diseases;liver injury;loss of function;Malnutrition;Mediating;Mediator;member;Metabolic;Modeling;Molecular;Molecular Weight;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Muscle Fibers;muscle form;muscle hypertrophy;Muscle satellite cell;Muscular Atrophy;National Institute on Alcohol Abuse and Alcoholism;novel;nutritional supplementation;Oral;Organ;Outcome;Pathway interactions;patient population;Patients;Pharmacotherapy;Physiological;Play;Polymers;Polysaccharides;pre-clinical;preclinical study;Preparation;prevent;Prevention;problem drinker;Protein Biosynthesis;proteostasis;proteostasis loss;Publishing;receptor;Receptor Signaling;Reporting;response;Role;sarcopenia;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle metabolism;skeletal muscle wasting;targeted treatment;Testing;Therapeutic;therapeutic target;tissue injury;Tissues;TLR4 gene;Toll-like receptors;Transforming Growth Factor beta;Translating;translational therapeutics;treatment response;treatment trial

PROJECT_TITLE: Novel mechanism based treatment to improve tissue injury in alcoholic hepatitis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Dementia;Emerging Infectious Diseases;Gene Therapy;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Prion disease is a fatal and untreatable neurodegenerative disease caused by misfolding of a single protein in the brain — prion protein or PrP. Here we apply divalent short interfering RNA (di-siRNA) technology to lower the amount of PrP in the brain, with the goal of advancing a safe and effective therapy for prion disease.

PI_NAMEs: MINIKEL, ERIC VALLABH (contact)

PROGRAM_OFFICER_NAME: BOSHOFF, CHRIS

PROJECT_TERMS: Animal Model;Animals;Antisense Oligonucleotides;Awareness;Biodistribution;Biological Assay;Biological Markers;Brain;Brain Diseases;Brain region;Central Nervous System;Cerebral hemisphere;Cerebrospinal Fluid;Cessation of life;Chemicals;Chronic;Clinical;clinical development;Clinical Research;conditioning;Creutzfeldt-Jakob Syndrome;Data;Dementia;Development;Disease;Dose;Dose Limiting;drug candidate;Drug Kinetics;drug production;effective therapy;Enzyme-Linked Immunosorbent Assay;Event;Fatal Familial Insomnia;first-in-human;Funding;Future;Genes;Genetic;genetic predictors;genetic testing;Gerstmann-Straussler-Scheinker Disease;Goals;Grant;Human;Human Cell Line;human study;humanized mouse;Investigational Drugs;Investigational New Drug Application;knock-down;Laboratories;Lead;Life;Macaca fascicularis;Mammals;Manufacturer;manufacturing process;medical schools;meetings;Modality;Molecular;Molecular Conformation;Mus;National Institute of Neurological Disorders and Stroke;Neurodegenerative Disorders;Neurons;novel;oligonucleotide therapeutics;Onset of illness;Patients;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology and Toxicology;Pilot Projects;pre-clinical;prevent;Preventive measure;Prion Diseases;Prions;Process;Production;protein expression;protein misfolding;Proteins;PrP;PrP gene;Qualifying;Rattus;Reporting;Research Personnel;Research Support;Residual state;response;Risk;RNA;Small Interfering RNA;standard of care;success;Symptoms;Technology;Testing;Therapeutic;therapeutic siRNA;Time;Toxic effect;transcriptome sequencing;United States Food and Drug Administration;Validation;Work

PROJECT_TITLE: Advancement of Prion Protein-Lowering Divalent siRNA Therapy for Prion Disease


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Interleukin-38 is a small protein made by the body in response to inflammation or an infection. Interleukin-38 reduces inflammation. The project will produce Interleukin-38 a therapeutic to treat various inflammatory diseases in humans.

PI_NAMEs: DINARELLO, CHARLES ANTHONY (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;Affect;Age;Aging;Agonist;Alanine;antagonist;Anti-Inflammatory Agents;Antibodies;Aorta;aortic valve;aortic valve disorder;Autoimmune Diseases;B-Lymphocytes;Binding;Biological;Biology;calcification;Calpain;Cardiovascular system;Cells;Chimeric Proteins;clinically significant;Consensus Sequence;CRISPR/Cas technology;cytokine;Data;Development;dextran sulfate sodium induced colitis;Disease;disease model;disorder risk;Dose;Event;Exhibits;experimental study;Family;Fc domain;Fc Immunoglobulins;Female;Fever;Genetic Polymorphism;Goals;Grant;High Fat Diet;Homeostasis;Human;human data;human disease;human male;human model;IgG1;IL17 gene;IL18 gene;Immunoglobulin G;In Vitro;in vivo;Incidence;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Interleukin Receptor;Interleukin-1;Interleukin-1 Receptors;interleukin-22;Interleukins;Lesion;Leucine;Ligands;Link;Location;Macrophage;male;man;Medical;member;Modeling;monocyte;monomer;mouse model;Mouse Protein;Mouse Strains;Mus;Myeloid Cells;Natural Immunity;neglect;Obesity;Oral;Orphan;Pathogenesis;Pathway interactions;Patients;Peptide Signal Sequences;pre-clinical;prevent;Production;Property;Proteins;receptor;Recombinant Interleukins;Recombinants;Reporting;Research;Research Design;response;Risk;Role;Schedule;Severity of illness;Signal Transduction;Site;Testing;Therapeutic;Therapeutic Uses;trinitrobenzene sulfonic acid induced colitis;Wild Type Mouse;Woman;women versus men;X Chromosome

PROJECT_TITLE: Pathogenesis of Fever in Man

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Lymphatic Research;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative Despite advances in operative technology, intraoperative methods have not improved cancer detection during surgery in the past 30 years. In response to the recent Moonshot Initiative PAR-20-250 that solicits “concepts that propose a path to clinical validation … for probes with previously demonstrated capabilities for the detection of small tumors”, we propose to test the combination of high- resolution/depth-limited imaging properties of optical imaging agents with the low-resolution/tissue penetrating properties of nuclear agents for detection of primary tumors and regional lymph nodes. We propose that combined optical and nuclear imaging can detect tumor fragments less than 1 mm3 in vivo during removal of head and neck cancers.

PI_NAMEs: ROSENTHAL, EBEN L. (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Antibodies;Cancer Detection;Cell Aggregation;Cervical lymph node group;Clinical;clinical application;Clinical Data;clinically significant;Decision Making;Deposition;design;Detection;draining lymph node;Eligibility Determination;Epidermal Growth Factor Receptor;Event;Excision;Failure;Fc Receptor;fluorescence imaging;Guidelines;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Image;Image-Guided Surgery;imaging agent;imaging detection;imaging modality;imaging properties;improved;in vivo;innovation;Label;Lesion;Location;lymph nodes;Lymphatic;Measures;Methods;Molecular;molecular imaging;Molecular Target;Neck;Neck Dissection;neoplastic cell;novel;Nuclear;nuclear imaging;operation;Operative Surgical Procedures;optical imaging;Optics;Outcome;panitumumab;Patient Schedules;Patients;Penetration;Pilot Projects;Positive Lymph Node;Primary Neoplasm;Procedures;Property;Request for Applications;Residual Neoplasm;Resolution;response;Signal Transduction;single photon emission computed tomography;Site;Specificity;Specimen;standard of care;Technology;Testing;Tissues;tumor;Validation;wound bed;X-Ray Computed Tomography

PROJECT_TITLE: Targeted Dual Modality Imaging for Detection and Removal of Head and Neck Cancer

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ALBUQUERQUE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: PROJECT NARRATIVE This study tests the effectiveness of a community-based peer advocacy, mutual learning, and social support intervention (Refugee and Immigrant Well-being Project) to reduce several negative consequences of the COVID-19 pandemic that are disproportionately impacting Latinx and Black populations: psychological distress, financial problems, and daily stressors. In partnership with five community-based organizations that focus on mental health, legal, education, and youth issues with Latinx immigrants and African refugees, we will also be able to examine the effects of people’s involvement with community-based organizations and local and state policy changes on their mental health, economic stability, stressors, and social support. This is important not only for Latinx and Black populations and the large number of immigrants and refugees in the United States and worldwide, but also because the intervention model and what we learn from this study have the potential to alleviate mental health disparities experienced by other marginalized populations who face unequal access to social and material resources, disproportionate exposure to trauma and stress, and worse consequences of the COVID-19 pandemic.

PI_NAMEs: GOODKIND, JESSICA R (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Address;adverse outcome;Advocacy;Affect;African;Awareness;barrier to care;behavioral economics;Black Populations;Black race;Collaborations;Communities;community based participatory research;community engagement;community organizations;comparison group;comparison intervention;Complex;Control Groups;COVID-19;COVID-19 incidence;COVID-19 pandemic effects;COVID-19 prognosis;cultural health;Data;design;Disasters;Discrimination;Disparate;Disparity;disparity reduction;economic impact;Economics;Education;Effectiveness of Interventions;effectiveness testing;Enrollment;Essential worker;experience;Exposure to;Family;Financial Hardship;food insecurity;Goals;Grief reaction;Health;health care availability;health disparity;health economics;Health Insurance;health service use;Housing;Immigrant;Immigration;improved;Individual;Inequity;innovation;Insurance Coverage;Intervention;intervention effect;Interview;Language;Latinx;Latinx population;Learning;Legal;Low income;marginalized population;Mediating;Mental Health;Mental Health Services;Methods;Modeling;mutual learning;Occupations;outcome disparities;pandemic disease;pandemic impact;Participant;Pathway interactions;peer;Personal Satisfaction;Persons;physical conditioning;Policies;primary outcome;Probability Samples;protective factors;psychological distress;Randomized;recruit;Refugees;Research;Research Design;research study;Resources;response;Sampling;Science;secondary outcome;Site;social;Social Change;social determinants;Social support;socioeconomics;Stress;stressor;System;Testing;Time;trauma exposure;treatment as usual;United States;university student;Waiting Lists;Work;Youth

PROJECT_TITLE: Multilevel Community-Based Mental Health Intervention to Address Structural Inequities and Adverse Disparate Consequences of COVID-19 Pandemic on Latinx Immigrants and African Refugees

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(58)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Heart Disease;Patient Safety;Physical Activity

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE The overarching goal of this study is to test whether a promising new therapy, inorganic nitrate, can improve exercise capacity — both muscle power and aerobic performance — in patients debilitated by heart failure. We will develop all the infrastructure necessary for a randomized clinical trial (RCT) of inorganic nitrate, including the necessary drug testing and human studies protections, and then we will perform a RCT of inorganic nitrate’s effects on exercise capacity. If inorganic nitrate is found safe and effective for improving aerobic exercise capacity, muscle power, and speed of muscle contraction, it could offer a new therapy for millions of people suffering from heart failure.

PI_NAMEs: COGGAN, ANDREW R;PETERSON, LINDA RUTH (contact);SCHECHTMAN, KENNETH B.

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Activities of Daily Living;Acute;Aerobic;Aerobic Exercise;Affect;arm;Biological Availability;Breath Tests;Cachexia;capsule;Cardiac;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;Case Report Form;Chronic;Chronic disability;Cities;Clinical;clinical care;clinical center;clinical translation;Clinical Trials;Clinical Trials Data Monitoring Committees;Consent Forms;Data;Databases;Development;dietary;disability;Disease;Disease Outcome;Dose;Double-Blind Method;drug testing;effective therapy;Effectiveness;effectiveness evaluation;effectiveness testing;Enrollment;Event;Exercise;exercise capacity;Exercise Test;Exercise Tolerance;FDA approved;Functional disorder;Future;Goals;Grant;Half-Life;Heart;Heart failure;heart failure with reduced ejection fraction;hemodynamics;Hospitalization;Hour;Human;Impairment;improved;Infrastructure;Ingestion;Institutional Review Boards;Iowa;Isotonic Exercise;Kansas;Left Ventricular Ejection Fraction;Manuals;Measurement;Measures;Minnesota;Monitor;mortality;Muscle;Muscle Contraction;Muscle function;Myocardial dysfunction;New York;Nitrates;Nitric Oxide;Nitrites;Nitrogen Dioxide;novel;novel therapeutics;Nursing Protocols;operation;Oral;Oxygen Consumption;Participant;participant enrollment;Pathway interactions;Patients;Performance;Persons;Pharmacodynamics;pharmacologic;Pharmacologic Substance;Phase;phase 2 study;phase 3 study;Phase II Clinical Trials;Phenotype;physically handicapped;Physicians;Placebo Control;Placebos;Plasma;primary endpoint;Procedures;Production;Prognosis;Protocols documentation;Pump;quadriceps muscle;Questionnaires;Randomized;randomized, clinical trials;recruit;reduce symptoms;remediation;Research;Research Design;respiratory gas;Rest;Safety;safety testing;screening;secondary endpoint;side effect;skeletal abnormality;Skeletal Muscle;Speed;Surveys;Symptoms;targeted agent;Testing;Time;Translational Research;treadmill;trial design;Universities;Update;Vasodilation;Visit

PROJECT_TITLE: The Inorganic Nitrate and eXercise performance in Heart Failure (iNIX-HF): - a phase II clinical trial

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Precision Medicine;Radiation Oncology;Women's Health Research

PHR: PROJECT NARRATIVE This project tests whether inhibition of metabolism of the amino acid glutamine will improve the response of cervical cancer to radiation therapy. State of the art cell culture systems, mouse tumor models and a new clinical trial for patients with cervical cancer will be used to evaluate this new treatment approach.

PI_NAMEs: SCHWARZ, JULIE KRISTINA (contact)

PROJECT_TERMS: 18F-Glutamine;3-Dimensional;amino acid metabolism;Animals;anti-tumor immune response;Biological Availability;Biological Markers;Biopsy;Blood;Brachytherapy;Cancer Therapy Evaluation Program;Carbon;Cell Culture System;cell growth;Cells;Cervix Neoplasms;chemoradiation;Cisplatin;clinical translation;Clinical Trials;clinically relevant;Coculture Techniques;cytotoxic;Data;design;Diagnosis;Disease;Dose;Dose Rate;Equilibrium;experimental study;External Beam Radiation Therapy;first-in-human;Flow Cytometry;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Fractionation;Future;Genetically Engineered Mouse;glucose metabolism;Glutaminase;Glutamine;Glutathione Metabolism Pathway;Human;Human Papillomavirus;Hypoxia;image guided;Immune;Immunocompetent;improved;In Vitro;in vivo;Inflammatory;inhibitor;Investigational Drugs;Label;Lead;Libraries;Macrophage;Malignant neoplasm of cervix uteri;Mass Spectrum Analysis;Mediating;Metabolic;metabolic imaging;Metabolism;metabolomics;Modeling;Monitor;Mus;mutant;Mutation;neoplastic cell;new combination therapies;novel;novel therapeutic intervention;Nucleotides;Nutrient;Oral;Output;Oxidation-Reduction;Oxidative Stress;Pathway interactions;patient derived xenograft model;Patients;Phase I/II Clinical Trial;Phenotype;Physiological;PIK3CA gene;PIK3CG gene;Positron-Emission Tomography;pre-clinical;preclinical study;predicting response;predictive marker;Property;Publishing;Pyruvate;Radiation;radiation effect;radiation resistance;Radiation therapy;Radiation Tolerance;radioresistant;Radiosensitization;Recurrence;Research;Research Personnel;Resistance;response;Safety;Source;Specimen;standard of care;Stimulus;Sulfhydryl Compounds;synergism;System;targeted exome sequencing;Testing;three dimensional cell culture;Time;transcriptome sequencing;Treatment Efficacy;treatment response;treatment strategy;tumor;Tumor Immunity;tumor metabolism;tumor microenvironment;two-dimensional;uptake;Work;Xenograft Model

PROJECT_TITLE: Optimizing radiation therapy through the manipulation of glutamine metabolism

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NORTHRIDGE

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

PHR: Narrative: The Bridges to the Doctorate Training Program is structured to provide opportunities to the participants that will engage them in research and didactic courses that will increase their knowledge in their chosen field of research, promote their self-efficacy as scientists. It will enhance and establish connections between CSUN and Ph.D. granting institutions. Ultimately, these partnerships will help to address the need for a well- trained diverse basic biomedical workforce.

PI_NAMEs: HARADA, JOHN J;HOGUE, CHERYL ;HONG, RAY L;MADURO, MORRIS F;OLZMANN, JAMES A;ROTHMAN, JOEL H.;STEELE, LATISHYA J;ZAVALA, MARIAELENA B (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: bridge to the doctorate;Research Training;Training Programs

PROJECT_TITLE: Bridges to the Doctorate Research Training Program at CSUN

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Lung adenocarcinoma (LUAD) is the most common cause of cancer mortality worldwide and is difficult to target therapeutically due to substantial heterogeneity and lineage plasticity that arises during progression and therapeutic response. However, the mechanisms controlling differentiation state and plasticity in LUAD are not well understood, and there is an urgent unmet need to identity drivers of LUAD plasticity both during progression and therapeutic response. This proposal will investigate the mechanisms by which key lineage specifying transcription factors and oncogenic signaling pathways concomitantly influence LUAD growth and differentiation state, and the results that derive from this study may help to inform development of lineage-targeted therapies for LUAD.

PI_NAMEs: FORT, GABRIELA M (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Adopted;Affect;Alveolar;Binding;Biological Assay;Cancer Etiology;Cell Differentiation process;Cell Line;Cells;Cessation of life;ChIP-seq;Chromatin;Data;Development;Differentiation and Growth;Disease;Disparate;Epigenetic Process;Evolution;experimental study;gastrointestinal;Gastrointestinal tract structure;Genes;Genetic;genetic approach;Genetic Transcription;Growth;Heterogeneity;HNF4A gene;Human;innovation;insight;interest;K-ras mouse model;knock-down;Knowledge;KRAS2 gene;Ligation;liver development;Lung;Lung Adenocarcinoma;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;MAP Kinase Gene;Measures;Mediating;MEKs;Modeling;Molecular;mortality;mouse model;Mus;mutant;Mutation;neoplastic cell;Nuclear Receptors;Oncogenic;Organoids;Pathway interactions;pharmacologic;Phosphorylation;programs;Proliferating;protein complex;Research;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;Stomach;subcutaneous;targeted treatment;Testing;Therapeutic;transcription factor;transcriptome sequencing;treatment response;tumor;tumor growth;tumor progression;tumorigenesis;Visualization;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Investigating molecular regulators of a mixed-lineage state in lung adenocarcinoma


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Complementary and Integrative Health;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome;Nutrition

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE Non-typhoidal Salmonella infects the gastrointestinal tract and is a leading cause of morbidity and mortality worldwide. We aim to understand how Salmonella thrives in the inflamed gut, and how beneficial microbes can outcompete Salmonella in this hostile environment. Our long-term goal is to develop new strategies to limit Salmonella infection.

PI_NAMEs: RAFFATELLU, MANUELA  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: acquired immunity;Affinity;anti-microbial peptide;antimicrobial;Bacteria;beneficial microorganism;Bile Acids;Colitis;Complex;cytokine;Enabling Factors;Enterobacteriaceae;Environment;Epithelial Cells;Escherichia coli;Ferrichrome;Fluorescent in Situ Hybridization;Gastrointestinal tract structure;Goals;gut inflammation;gut microbiome;gut microbiota;Homeostasis;Immune response;Immunity;In Vitro;in vivo;Infection;Inflammation;Inflammatory Response;Integration Host Factors;interleukin-22;Iron;Laboratories;LCN2 gene;Leukocyte L1 Antigen Complex;Manganese;MccJ25;Metabolic;Metagenomics;Metals;metatranscriptomics;Microbe;microbial;microbiota;microcin;Modeling;Morbidity - disease rate;mortality;Mucous Membrane;Neutrophil Infiltration;non-typhoidal Salmonella;novel strategies;Nutrient;Nutritional;Nutritional Immunity;pathogen;Pathogenesis;Periodicity;Probiotics;Process;Production;Proteins;receptor;Research;response;Role;Salmonella;Salmonella infections;Salmonella typhimurium;Side;System;T-Lymphocyte;Testing;Virulence Factors;Work;yersiniabactin;Zinc

PROJECT_TITLE: Nutritional immunity during Salmonella infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-K(90)]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: The Center Core Grant for Vision Research at the University of Houston increases knowledge about the structure and function of the visual system, and improves visual health by supporting investigators in individual labs, and in collaborations across labs and disciplines, in innovative research on vision and vision disorders.

PI_NAMEs: FRISHMAN, LAURA J. (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Area;Biological;Biomedical Engineering;Biometry;Center Core Grants;Clinical;Clinical Sciences;Collaborations;college;computer program;Core Grant;design;Discipline;Disease;Environment;Equipment;Equity;experience;Faculty;forging;Funding;Future;Grant;Health;Image;improved;Individual;innovation;Institution;instrument;instrumentation;interest;Knowledge;Optometry;Paper;Positioning Attribute;prevent;Productivity;Publishing;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resources;Running;Scientist;Services;Structure;Talents;Training;United States National Institutes of Health;Universities;Vision;Vision Disorders;Vision research;vision science;Visual;Visual impairment;Visual System

PROJECT_TITLE: Center Core Grant for Vision Research


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision

PROJECT_TITLE: Administrative Core


PI_NAMEs: YOON, GEUNYOUNG  (contact)

PROJECT_TITLE: Instrument Design Module


NIH_SPENDING_CATS: Bioengineering;Data Science;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: DAS, VALLABH E (contact)

PROJECT_TERMS: Algorithms;Appointment;Biomedical Engineering;Center Core Grants;Code;Collaborations;Communication;computer program;Computer software;Consultations;Custom;data acquisition;data management;Doctor of Philosophy;Documentation;Equity;experience;Funding;graduate student;Individual;innovation;instrumentation;Investigation;Joints;neurophysiology;oculomotor;Optometry;professor;recruit;repository;Research;Research Personnel;Resources;Rotation;Services;Software Design;software development;Source Code;Supervision;System;Universities;Vendor;Vision research;vision science

PROJECT_TITLE: Research Computer Programming Module


NIH_SPENDING_CATS: Infectious Diseases;Obesity

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE- Acetyl CoA Carboxylase in the Metabolic Control of Inflammation Metabolic dysregulation in immune cells results in either compromised or overshooting innate immune responses, resulting in devastating outcomes in resolution of infections. Acetyl CoA Carboxylase (ACC) is a key enzyme directly regulating de novo lipogenesis as well as indirectly affecting transcriptional capacity by regulating acetyl-CoA levels and histone acetylation. Here, we test the overall hypothesis that ACC activity is essential for the immune cell-intrinsic metabolic and transcriptional adaptations required for the induction and resolution of the acute inflammatory response.

PI_NAMEs: LEITINGER, NORBERT  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Acetyl Coenzyme A;Acetyl-CoA Carboxylase;Acute;aerobic glycolysis;Affect;ATAC-seq;Bacterial Infections;Bioenergetics;Cells;Chromatin;chromatin immunoprecipitation;Clinical Trials;Diabetes Mellitus;Down-Regulation;Endotoxemia;Enzymes;Escherichia coli;Etiology;Failure;Gene Expression Profiling;Genetic;Genetic Transcription;Glucose;Histone Acetylation;Homeostasis;Host Defense;Ice;Immune;Immune response;Immune system;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;Innate Immune Response;Interferon Receptor;Link;lipid biosynthesis;lipid mediator;lipid metabolism;lipidomics;Lipids;Macrophage;Malignant Neoplasms;Mass Spectrum Analysis;membrane synthesis;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;mouse model;Mus;Myelogenous;nonalcoholic steatohepatitis;novel;Obesity;Outcome;oxidation;Oxidative Phosphorylation;pathogen;Pathway interactions;Patients;Pattern recognition receptor;pharmacologic;Phospholipids;Production;Protein Acetylation;Protein Isoforms;Proteomics;Reaction;Recovery;recruit;Reporting;Research;Resolution;response;Risk;Role;Salmonella;Signal Transduction;Signaling Molecule;Site;Testing;Toll-like receptors;Virus Diseases


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

PI_NAMEs: MANNY, RUTH E (contact)

PROJECT_TERMS: Applications Grants;Appointment;Basic Science;Biometry;Biostatistics Core;career;Center Core Grants;Clinical;Clinical Research;Collaborations;Computer software;Consult;Data;data acquisition;data management;Doctor of Philosophy;Equity;Evaluation;experience;Faculty;Funding;Instruction;Joints;Measurement;mid-career faculty;Preparation;professor;Reporting;Research;Research Design;research faculty;Research Personnel;Resources;Sample Size;Seasons;Services;Statistical Data Interpretation;statistical service/center;statistics;Students;Supervision;Texas;Training;Translational Research;Universities;Vision research;Writing

PROJECT_TITLE: Biostatistical Support Module


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision

PI_NAMEs: PATEL, NIMESH BHIKHU (contact)

PROJECT_TERMS: 3-Dimensional;Animals;Biological;Biophysics;Center Core Grants;Computer Assisted;Computer-Assisted Image Analysis;Confocal Microscopy;Cornea;Doctor of Philosophy;Electron Microscopy;Equipment;Equity;Face;Fluorescence Microscopy;Funding;Grant;Histology;Human Resources;Image;Image Analysis;imaging facilities;imaging Segmentation;in vivo;in vivo imaging;Individual;innovation;interest;Light;light microscopy;live cell imaging;Microscopy;Molecular;Optical Coherence Tomography;reconstruction;Research;Research Personnel;Resolution;Resources;Retina;Scanning Electron Microscopy;Services;skills;Techniques;tissue preparation;tomography;Training;Transmission Electron Microscopy;two photon microscopy;Universities;Vision research

PROJECT_TITLE: Biological Imaging Module


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Biomolecular condensates play important roles in the organization and function of human cells, and are defective in diseases including neurodegeneration (amyotrophic lateral sclerosis, frontotemporal dementia), many cancers (e.g. Ewing sarcoma) and several skin barrier diseases. This proposal will address key problems in the field whose solutions could lead to new therapeutic approaches based on targeting biomolecular condensates. These include the sequence determinants of phase separation of intrinsically disordered proteins, the compositional and functional complexity of native condensates, and the contribution of phase separation to organization and functions of chromatin.

PI_NAMEs: ROSEN, MICHAEL K (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;amyloid formation;Amyotrophic Lateral Sclerosis;Base Composition;Biochemical;Biological;Biological Process;Biophysics;Cells;Chromatin;Client;Disease;Drug Design;Encapsulated;Eukaryotic Cell;Ewings sarcoma;experimental study;Filament;Frontotemporal Dementia;Gene Expression;Genetic Transcription;Genome;Genomic Segment;Histones;Human;Individual;insight;Lead;Learning;Liquid substance;macromolecule;Malignant Neoplasms;Membrane;Microfluidics;Modeling;Modification;Mutation;Nerve Degeneration;novel strategies;novel therapeutic intervention;Nucleosomes;Nut carcinoma;Pattern;Phase;Physical condensation;Play;Post-Translational Protein Processing;predictive modeling;Process;programs;Protein Region;Proteins;Regulation;RNA;RNA Helicase;RNA metabolism;Role;scaffold;self assembly;Signal Transduction;Signaling Molecule;skin barrier;skin disorder;small molecule;Solid;Time;Work;Yeasts

PROJECT_TITLE: Cell Organization Through Phase Separation:  Mechanisms, Functions and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: In this proposal we will develop and optimize a targeted mass spec-based assay for glycopeptide markers discovered in our previous work for the early detection of hepatocellular carcinoma (HCC). These glycopeptide markers are orthogonal to ELISA based AFP detection so that they will contribute to an overall increase in the AUC and sensitivity for detection of early HCC. We will perform an analysis of a large confirmation set to determine the optimal combination of glycopeptide markers and then a phase II blinded validation of these markers for early stage HCC detection.

PI_NAMEs: LUBMAN, DAVID M. (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Abdomen;Address;Archives;bioinformatics tool;Biological Assay;Biological Markers;biomarker performance;biomarker validation;Blinded;Cancer Etiology;carbohydrate structure;Cessation of life;Characteristics;Cirrhosis;Clinical;Clinical Data;Clinical Treatment;Complex;Computer software;Coupled;curative treatments;Data;Databases;Detection;detection sensitivity;Disease;early detection biomarkers;Early Detection Research Network;Early Diagnosis;Enzyme-Linked Immunosorbent Assay;Ethnic Origin;Etiology;Glycopeptides;Glycoproteins;glycoproteomics;glycosylation;Goals;Guidelines;Haptoglobins;high risk;improved;Incidence;innovation;Isomerism;Laboratories;Lectin;Liver diseases;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Methods;Minor;Monitor;multiplex assay;novel;Patients;Peptides;Performance;Phase;Polysaccharides;Primary carcinoma of the liver cells;Professional Organizations;Proteins;Publishing;Race;Reaction;Recommendation;Sampling;screening;Screening for cancer;Serum;sex;sialylation;Site;Specificity;Structure;success;surveillance strategy;Survival Rate;tandem mass spectrometry;Techniques;Testing;ultrasound;Validation;Work;α-Fetoproteins

PROJECT_TITLE: Serum Glyco-Markers of Early Hepatocellular Carcinoma Using a Mass Spec Approach

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Biotechnology;Neurosciences

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Healthy brain activity depends on intercellular signaling between neuronal synapses and extracellular proteins produced from astrocytes. We aim to understand the specific mechanisms underlying this astrocyte-neuron relationship in human cells using bioengineered neural organoids as an experimental testing platform. The results from this study are expected to elucidate the influence of astrocyte-neuron interactions, to deliver validated innovations that will improve organoid-based technologies, and to identify proteins with high potential as therapeutic targets during states of dysregulated brain activity.

PI_NAMEs: KRENCIK, ROBERT CONRAD (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Acceleration;Adherent Culture;Alginates;Astrocytes;Back;Biological Assay;Biological Models;Biomedical Engineering;Brain;Brain Diseases;Calcium;capsule;Cell Line;Cell Lineage;cell type;Cells;Chondroitin Sulfate Proteoglycan;Clinical;Coculture Techniques;Communities;Comprehension;Data;density;Disease;Encapsulated;Environment;excitatory neuron;Excitatory Synapse;extracellular;Extracellular Protein;Feedback;Genetic Engineering;glutamatergic signaling;Health;high throughput screening;Human;Human Characteristics;human pluripotent stem cell;Hydrogels;Image;improved;in vivo;Induced Neurons;innovation;Intervention;Knowledge;Lead;Ligands;Modeling;multi-electrode arrays;Nervous System;neural;neural network;Neurobiology;Neurons;Neurosciences Research;novel;novel strategies;optogenetics;Organoids;Pharmacological Treatment;Pharmacotherapy;physical separation;Play;postmitotic;pre-clinical;Proteins;Protocols documentation;receptor;Role;Signal Transduction;Synapses;synaptic function;synaptogenesis;Technology;Testing;therapeutic target;Thrombospondin 1;tool

PROJECT_TITLE: Relationship of the Human Astrocyte Matrisome with Synaptic Networks

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Diabetes;Genetics;Nanotechnology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Islet transplantation is a promising therapy to achieve stable blood glucose control for T1D patients. To overcome the shortage of islet supply, we developed a novel technology to direct cultured human stomach stem cells to generate insulin-secreting β-like cells capable of reversing diabetes. We propose to significantly improve this technology by constructing unique cell lines and new tools to produce islet-like organoids with improved functionality and streamlined production suitable for clinical translation.

PI_NAMEs: RAFII, SHAHIN  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Adoption;Adult;Alpha Cell;Autopsy;Beta Cell;Binding;Biopsy;Blood Glucose;blood glucose regulation;Cell Line;cell type;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;clinical translation;Clone Cells;D Cells;Data;Derivation procedure;Diabetes Mellitus;diabetic;Diabetic mouse;Enhancers;Frequencies;Functional disorder;gastrointestinal;GCG gene;Genes;Genetic Transcription;Genomics;Glucagon;Glucose;glucose monitor;Glucose tolerance test;Goals;Human;Immune;improved;In Vitro;in vivo;insight;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans;Islets of Langerhans Transplantation;Knock-out;Laboratories;large scale production;Maps;Measures;Messenger RNA;Methods;Mus;Names;nanoparticle;new technology;novel;NPM1 gene;Organoids;paracrine;Patients;Production;Proliferating;reconstitution;response;Sampling;single-cell RNA sequencing;Stains;stem cells;Stomach;Structure of beta Cell of islet;Technology;Tissue Grafts;Tissues;tool;Transcriptional Activation;translational potential;Transplantation;tumor

PROJECT_TITLE: Derivation of pancreatic islet-like organoids from human gastric stem cells


NIH_SPENDING_CATS: Aging;Genetics;Infectious Diseases

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Mitochondria are the hub of multiple cellular processes including metabolism and immune responses, and are intimately associated with organismal aging. The extracellular matrix is a dynamic organelle that mediates communication between cells and regulate fundamental cellular behaviors. The extracellular matrix also undergoes profound remodeling during aging. We aim to understand how mitochondrial homeostasis is regulated by changes of the extracellular matrix and its impact on aging.

PI_NAMEs: DILLIN, ANDREW G (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Address;age related;age related changes;Aging;aging process;Binding;biological adaptation to stress;Caenorhabditis elegans;Candidate Disease Gene;cell behavior;Cell membrane;Cell Physiology;Cells;Cellular Stress;Collagen;Communication;Data;Disease;Endoplasmic Reticulum;endoplasmic reticulum stress;Exhibits;Extracellular Matrix;Extracellular Matrix Degradation;Fibroblasts;follow-up;functional decline;functional genomics;gene function;Genes;Genetic;Genetic Models;Genomic approach;Global Change;Glycoproteins;Glycosaminoglycans;Health;Homeostasis;Homologous Gene;host microbiome;Human;Hyaluronan;Hyaluronic Acid;Hyaluronidase;Immune response;Immunity;improved;in vivo;Infection;Inflammation;Innate Immune Response;intercellular communication;life span;Link;Longevity;Lysosomes;Maintenance;Malignant Neoplasms;Mammals;Mass Spectrum Analysis;Mediating;Metabolism;Mitochondria;mitochondrial DNA mutation;mitochondrial dysfunction;Mitochondrial Matrix;Modeling;Molecular;Mus;Mutagenesis;Natural Immunity;Nematoda;Nerve Degeneration;novel;Organelles;Organism;overexpression;Oxidative Stress;Paraquat;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;physical property;Physiological;Play;protein folding;Proteins;proteostasis;Quality Control;Resistance;Respiration;response;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Stress;Testing;tissue stress;Tissues;Transforming Growth Factor beta;Validation;Vertebrates;Virulence Factors;wound healing

PROJECT_TITLE: Extracellular Matrix Control of Mitochondrial Homeostasis and Longevity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-Z(52)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Prevention;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: HADLEY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Heavy alcohol use remains a serious problem among college students. Brief motivational interventions reduce college students' alcohol use but effects are not sustained. This research seeks to identify the psychosocial factors that affect college students' maintenance of intervention gains over time and to conduct the formative research needed to develop a maintenance-enhancement alcohol intervention for college students.

PI_NAMEs: REID, ALLECIA E. (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Adolescent and Young Adult;Affect;alcohol consequences;Alcohol consumption;alcohol intervention;alcohol related consequences;Applications Grants;Behavior;behavior change;Body Weight decreased;brief alcohol intervention;brief intervention;brief motivational intervention;Categories;Cessation of life;Communication;coping;cost;Data;drinking;efficacious intervention;efficacy evaluation;Empirical Research;Engineering;Enrollment;Evaluation;experience;Experimental Designs;Goals;Grant;handbook;Health;Health behavior change;Heavy Drinking;improved;Individual;Injury;innovation;Intervention;Investments;Knowledge;Learning;Literature;longitudinal analysis;Longitudinal Studies;Maintenance;Massachusetts;Measures;Mental Health;Mentors;Mentorship;Methods;Modeling;multiphase optimization strategy;Outcome;Parents;Participant;Performance;Phase;physical conditioning;pilot test;post intervention;Preparation;Process;psychosocial;Psychosocial Factor;Public Health;public policy on alcohol;Randomized;Recommendation;Recovery;reduced alcohol use;relapse prevention;Research;Research Activity;Research Personnel;Risk;Science;Scientist;Self Efficacy;Services;sexual assault;skills;smoking cessation;Social support;Specific qualifier value;Students;systematic review;theories;Theory of Change;therapy development;Time;Training;Training Activity;underage drinking;United States National Institutes of Health;Universities;university student;Work;Writing;young adult

PROJECT_TITLE: Promoting Maintenance of Behavior Change Following Brief Alcohol Intervention

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: The traditional paradigm of how neurons work assumes that dendrites receive excitatory and inhibitory synaptic inputs that are integrated in the soma, but dendrites are active nonlinear structures that could mediate, and control, which of the many thousands of inputs are integrated and which are not. We will assemble an interdisciplinary consortium of laboratories and use state-of-the-art experimental and computational methods to examine with unprecedented detail the structure, in vivo function and computational roles of dendrites of a mouse pyramidal neuron subtype in visual cortex. This work will elucidate the principles underlying the function of dendrites in pyramidal neurons and generate a series of complete morphological, connectivity, functional and computational datasets that could be used as “Rosetta Stones” by the field for futures studies of neurons in both normal and pathological states.

PI_NAMEs: BASU, JAYEETA ;SEGEV, IDAN ;YUSTE, RAFAEL  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: 3-Dimensional;Action Potentials;Affect;analog;Anatomy;area striata;Axon;biophysical analysis;Biophysical Process;Brain;Calibration;cell type;Cells;Communities;Computer Models;Computing Methodologies;Data;Data Set;Dendrites;Dendritic Spines;design;Development;Dimensions;Disease;Elements;Engineering;Excitatory Postsynaptic Potentials;experimental study;Future;Generations;Goals;hippocampal pyramidal neuron;Holography;Image;improved;In Vitro;in vivo;Inhibitory Synapse;knowledge graph;Laboratories;Logic;Maps;Measurement;Measures;Mediating;Mental disorders;Methods;Microscopy;Modeling;Molecular;Morphology;Mus;Nervous System Disorder;network models;neuronal cell body;Neurons;Neurosciences;novel;optogenetics;Outcome;Output;patch clamp;Pathologic;phenomenological models;Play;public database;Pyramidal Cells;reconstruction;Research;Research Personnel;Resolution;response;Role;screening;Sensory;Series;Site;Structure;Synapses;Synaptic Potentials;synergism;Testing;Textbooks;Tissues;Trees;two-photon;ultra high resolution;Visual Cortex;voltage;WFS1 gene;Work

PROJECT_TITLE: Reexamining the Role of Dendrites in Neuronal Function


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE The Boston University and Lata Medical Research Foundation with the academic consortium of the Indira Gandhi Government Medical College and the Datta Meghe Institute of Medical Sciences in Nagpur, Central India focuses on improving the health of pregnant women, their newborns, and children up to 3 years of age. We are committed to the Global Network's objective to conduct high impact, clinical trials and observational studies of sustainable, cost-effective health interventions and their implementation in women and children in low and middle income countries. Continued participation in the Global Network will also enable us to continue building sustainable research capacity and infrastructure in obstetric, neonatal, and pediatric research in Nagpur, India.

PI_NAMEs: HIBBERD, PATRICIA L (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: 3 year old;Address;adolescent health;adverse outcome;Age;Agreement;Arabs;Area;Azithromycin;azithromycin resistance;Boston;Caring;Cesarean section;Cessation of life;Child;Child Health;Childhood;Clinical;clinical research site;Clinical Trials;Collaborations;Communicable Diseases;cost effective;Country;data access;data sharing;Death Rate;design;Devices;Disabled Persons;Discipline of obstetrics;Disparity;early childhood;Environmental Exposure;Exposure to;Faculty;fetal;Foundations;genome sequencing;global health;Goals;Government;Growth and Development function;Haplotypes;Health;Household Air Pollution;improved;indexing;India;Infant Malnutrition;Infant Mortality;Infrastructure;Institution;Intervention;Lactation;Lead;Leadership;Live Birth;low and middle-income countries;maternal depression;maternal risk;Medical;Medical Research;medical schools;Mentors;Metagenomics;microbiome;Mobile Health Application;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;National Institute of Child Health and Human Development;Neonatal;Neonatal Mortality;Neonatology;Newborn Infant;novel;Observational Study;patient engagement;Patients;Pediatric Research;Pediatrics;point-of-care diagnostics;Population;Population Heterogeneity;Populations at Risk;Pregnancy;pregnant;Pregnant Women;prepregnancy;Productivity;Protocols documentation;public health intervention;public health research;Publications;Rationalization;recruit;Reproducibility;reproductive;Research;Research Design;Research Infrastructure;Research Personnel;Resource-limited setting;retention rate;Risk;Role;Schools;Science;Sickle Cell Anemia;Site;Slum;Socioeconomic Status;Strategic Planning;Students;Sustainable Development;Testing;therapeutically effective;Time;Tribal group;Underserved Population;United Nations;Universities;Variant;whole genome;Woman;women's morbidity;Women's mortality;women's outcomes

PROJECT_TITLE: Boston University/Lata Medical Research Foundation Global Network for Women's Children's Health Research Unit