NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Immunotherapy

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Narrative: Development of heart failure after a heart attack is the most common reason for hospital admission. Understanding the temporal changes in the genetic and physiological profile of CD8+ T-cells will provide critical information regarding their role in wound healing after a heart attack and thus facilitating with the mission of the healthcare system.

PI_NAMEs: DELEON-PENNELL, KRISTINE Y (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Acute;adaptive immune response;Adverse effects;Anterior Descending Coronary Artery;Antigen Presentation;Antigen-Presenting Cells;Antigens;arm;Automobile Driving;Biological Assay;Biomechanics;Cardiac;CD8-Positive T-Lymphocytes;Cell Communication;Cell Separation;Cells;Cicatrix;clinical practice;cytotoxicity;Data;Development;differential expression;diphtheria toxin receptor;Echocardiography;Event;Extracellular Matrix;Fibrosis;Flow Cytometry;Functional disorder;Genetic;Genetic Transcription;genomic data;Genomics;Goals;healing;Health;Healthcare;Healthcare Systems;Heart failure;Heterogeneity;Hospitalization;Hypertrophy;Image;Immune;Immune system;immunoregulation;Impaired wound healing;Impairment;improved;improved outcome;Infarction;Infiltration;Inflammation;Injury;interdisciplinary approach;Intervention;Ischemia;Knowledge;Left;Left ventricular structure;Ligation;Macrophage;Macrophage Activation;Major Histocompatibility Complex;Maps;mass spectrometric imaging;Measures;Mediating;Mission;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Cells;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;Necrosis;Outcome Study;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Perfusion;Personal Satisfaction;Phase;Phenotype;physical property;Physiological;Population;prevent;Process;Property;Proteomics;recruit;Regulation;response;Role;Signal Transduction;Signaling Molecule;single cell sequencing;Stress;Stroke Volume;synergism;T cell clonality;T-Cell Activation;T-Cell Depletion;T-Cell Receptor;Testing;Time;Tissue imaging;Tissues;two-dimensional;Ventricular;Ventricular Dysfunction;Ventricular Remodeling;Visualization;wound healing

PROJECT_TITLE: Temporal effects of CD8 T-cells post-MI

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Nanotechnology;Rare Diseases;Tuberculosis

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative: There is a critical unmet need for a globally scalable, biomarker-based diagnostic for Tuberculosis (TB) from non-sputum-based samples. Here we will first develop a multiplexed microfluidic antibody profiling chip and use it, coupled with machine-learning approaches, to define an antibody Fe signature-based TB biomarker. Further, we will develop an inexpensive yet accurate nanoscale approach for detection of this biomarker from a single drop of blood at the point-of-care (POC).

PI_NAMEs: SARKAR, ANIRUDDH  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;analytical method;Antibodies;antibody detection;Antibody titer measurement;Antigen Targeting;Antigens;Area;Binding;Biological Assay;Biological Markers;biomarker discovery;Biophysics;Blood;cancer immunotherapy;Cause of Death;Cessation of life;Child;Classification;Clinical;clinical care;Clinical Management;cohort;Communicable Diseases;Complex;cost;Coupled;Data;Data Set;Detection;detection method;detection platform;Development;Diagnosis;diagnostic signature;diagnostic strategy;Disease;Drops;effective therapy;Electronics;flexibility;Geography;Glycoengineering;glycosylation;Goals;Graft Rejection;HIV;HIV/TB;Human;Immune;Immunologic Monitoring;improved;In Vitro;Infection;Inflammatory;Lectin;low and middle-income countries;Machine Learning;machine learning method;Mass Spectrum Analysis;Measurement;Measures;Methods;microchip;Microelectrodes;Microfluidics;Microscopy;Monitor;Monoclonal Antibodies;multidimensional data;multiplex assay;Mycobacterium tuberculosis;nanomaterials;nanoscale;Nanostructures;novel;novel marker;Optics;Outcome;pathogen;Pathogen detection;Pathology;Patients;Persons;point of care;point-of-care detection;point-of-care diagnosis;point-of-care diagnostics;Polymers;Population Heterogeneity;Preparation;prevent;Property;rapid detection;receptor binding;Resource-limited setting;Resources;response;Sampling;Scheme;Schistosomiasis;Sensitivity and Specificity;Sepsis;Serology test;Seroprevalences;Serum;specific biomarkers;Specificity;Sputum;Surface;Techniques;technology development;Testing;Thoracic Radiography;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;vaccine response;Validation;Vision;Work

PROJECT_TITLE: Microscale Multiplexed Antibody Fc Profiling and Nanoscale Electronic Detection for Rapid and Scalable Point-of-Care Diagnosis of Tuberculosis

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Clinical Research;HIV/AIDS

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative N/A

PI_NAMEs: OKAFOR, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Child Care

PROJECT_TITLE: Childcare Supplement to F31


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative With public health experts warning us of the increasing prevalence of adolescent mental health problems, it is of critical importance to understand the effects of social supports on mitigating the effects of trauma, particularly for minoritized youth, whose experiences are less understood. By following the same cohort of socio- demographically diverse adolescents in the longitudinal Adolescent Brain Cognitive Development study, we will identify the critical junctures by which trauma and social support impact behavioral functioning. Findings will lend guidance on how to make accessible the specific types of culturally relevant social supports that minimize symptoms of externalizing and internalizing behaviors due to adverse childhood experiences.

PI_NAMEs: GARCIA, ANTONIO RAYMOND (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 10 year old;Adolescence;Adolescent;adolescent mental health;Adult;adverse childhood events;Affect;Age;Attention;Behavior;Behavioral;behavioral outcome;Black race;Brain;Buffers;Caregivers;Child;Childhood;children of color;cognitive development;cohort;Communities;Data;Data Collection;Development;Dose;Emotional;Environmental Risk Factor;experience;Exposure to;externalizing behavior;Friends;Health;Indigenous;innovation;Long-Term Effects;longitudinal analysis;Measures;Mental Health;minority children;Modeling;Neighborhoods;Outcome;participant enrollment;peer;Population;Population Heterogeneity;Poverty;Prevalence;promote resilience;Protocols documentation;Psychopathology;Public Health;racial disparity;racial diversity;Recommendation;Reporting;Research;resilience;response;Risk;Role;Sampling;Service provision;Site;social;Social Network;Social support;sociodemographics;Surveys;Symptoms;Testing;Trauma;Trust;United States;young adult;Youth

PROJECT_TITLE: The Role of Social Supports in Mitigating the Effects of Adverse Childhood Experiences on Adolescent Psychopathology

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetic Testing;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Summary This project will develop a new way to easily test for the many genetic mutations responsible for resistance to key new drugs to treat tuberculosis in a single test using a simple device that could be used at the point of care. Important types of drug resistance will be easily and rapidly diagnosed. This innovative diagnostic could vastly simplify treatment decisions and potentially save hundreds of thousands of lives.

PI_NAMEs: ALLAND, DAVID  (contact)

PROJECT_TERMS: Address;aspirate;assay development;base;Biological Assay;causal variant;Cerebrospinal Fluid;Clinical;Collaborations;Companions;design;Detection;detection limit;Devices;Diagnostic;diagnostic development;diagnostic platform;Diagnostic tests;Disease;DNA Sequence Alteration;Drug resistance;Drug resistant Mycobacteria Tuberculosis;Feces;Fluoroquinolones;Foundations;Funding;Future;Genes;Grant;high risk;innovation;instrument;internal control;isoniazid;Laboratories;Length;Linezolid;low and middle-income countries;manufacture;Molecular;mutant;Mutation;Mutation Detection;Mycobacterium tuberculosis;novel diagnostics;novel therapeutics;Nucleic Acid Amplification Techniques;Pathway interactions;Patients;Performance;Pharmaceutical Preparations;Phase;point of care;point of care testing;point-of-care detection;point-of-care diagnostics;Predisposition;programs;rapid diagnosis;Reaction;Reagent;Research;Resistance;Resources;Rifampin;Risk;Sampling;Scientist;Sensitivity and Specificity;Specificity;Specimen;Sputum;Stomach;Swab;System;Temperature;Testing;Tube;Tuberculosis;tuberculosis diagnostics;tuberculosis drugs;tuberculosis treatment;United States National Institutes of Health;Urine;validation studies;Vertebral column

PROJECT_TITLE: Point of care detection of fluroquinolone, bedaquiline and linezolid resistant Mycobacterium tuberculosis for rapid treatment decisions.

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Approximately 200,000 new cases of ovarian cancer occur per year worldwide, but the overall survival of ovarian cancer has not significantly changed for decades. Nearly 20% of our genome is composed of LINE-1 transposable elements that are tightly silenced in normal tissues but gain expression in cancers, especially ovarian cancer. This project will determine how LINE-1 contributes to ovarian cancer immune evasion, potentially identifying vulnerabilities to novel therapies.

PI_NAMEs: BURNS, KATHLEEN H;CHIAPPINELLI, KATHERINE B (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Acute;Address;Affect;Antitumor Response;Automobile Driving;Binding;Biological;Burn injury;c-myc Genes;cancer cell;Cancer cell line;Cell Differentiation process;cell immortalization;Cell Line;Cells;Chronic;Code;Complementary DNA;Cytoplasm;Development;Diagnostic;DNA;DNA biosynthesis;DNA Damage;DNA Methylation;DNA Transposable Elements;Elements;embryonic stem cell;Epigenetic Process;epigenetic regulation;epigenetic silencing;Epithelium;Exhibits;experimental study;Genetic Transcription;Genome;genome-wide;genomic locus;Goals;histone modification;Human;Hybrids;Immune;immune checkpoint blockade;Immune Evasion;Immune signaling;immunogenicity;Immunologics;immunosuppressive macrophages;Immunotherapy;Infiltration;Inflammation;innovation;Interferon Type I;Interferons;L1 Elements;Lesion;Life Cycle Stages;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Measures;metaplastic cell transformation;Methylation;Modeling;mouse model;multiplexed imaging;Mus;mutant;Mutate;Mutation;MYC gene;Myeloid-derived suppressor cells;Normal tissue morphology;novel;novel therapeutics;Nucleic Acids;overexpression;Paste substance;Pathology;Prognosis;Proteins;Qualifying;Regulation;Regulatory T-Lymphocyte;Repression;response;Retrotransposition;Reverse Transcriptase Inhibitors;Reverse Transcription;RNA;Sampling;sensor;Serous;Signal Transduction;Stimulator of Interferon Genes;success;T-Lymphocyte;Technology;Testing;Therapeutic;TP53 gene;Transcriptional Regulation;Transcriptional Silencer Elements;tumor;Tumor Burden;Tumor Escape;tumor immunology;tumor microenvironment;tumor progression;Tumor Suppressor Genes;tumor-immune system interactions;women's diagnosis;Work

PROJECT_TITLE: Immunological consequences of LINE-1 expression in cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Q (80)]


NIH_SPENDING_CATS: Lung

ORG_CITY: Chicago

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE  Neutrophils are white blood cells that kill pathogens in infected tissues. I believe that these cells achieve their rapid host defense function by releasing their nuclei to facilitate cell deformation when working in the spatially restricted lung. This research will elucidate the mechanism of lung micro-environment specific neutrophil regulation and lead to more ideal therapies for patients with pulmonary infections and acute lung injury.

PI_NAMEs: TSUKASAKI, YOSHIKAZU  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Air;Algorithms;Alveolus;Area;Bacteria;bactericide;Blood;Blood capillaries;Calcium;Calcium Channel;Calcium Signaling;Calibration;Carbon Dioxide;cell killing;Cell Nucleus;Cell Shape;Cell Volumes;Cells;Characteristics;Complex;Computer Vision Systems;Data;design;Diameter;Disease Progression;Distal;Drug Modulation;Endothelium;Environment;Environmental Irritants;Enzymes;Exposure to;extracellular;Functional disorder;fungus;Gases;Genetic Transcription;Genetically Engineered Mouse;Genomic DNA;HIF1A gene;Histones;Homeostasis;Host Defense;Hypoxia Inducible Factor;imaging approach;imaging study;imaging system;Impairment;improved;Inflammation;Inflammation Process;Inflammatory;Injury;Intervention;intravital imaging;Leukocytes;Lung;lung imaging;Lung infections;lung injury;Mediating;Mediation;Methods;migration;Mitochondria;mitochondrial dysfunction;Molecular;Morphologic artifacts;Motility;Motion;Mus;Myeloid Cells;neutrophil;Neutrophil Infiltration;novel;Nuclear;Nutrient;Organ;Oxygen;Paralysed;pathogen;Pathway interactions;Patients;Piezo 1 ion channel;Play;Population;Probability;Process;Production;programs;Protein-arginine deiminase;Pulmonary Inflammation;Regulation;Research;residence;respiratory;response;Role;Secondary to;sensor;Signal Transduction;spatiotemporal;Stretching;Structure;System;Thinness;Time;Tissues;trafficking;Transplantation;Visualization

PROJECT_TITLE: Spatio-temporal regulation of pulmonary neutrophil plasticity

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Natural Products

ORG_CITY: ROCHESTER

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: The study of bioactive small molecules with complex structures can lead to discovery of new therapeutic agents for the treatment of disease. However, many of these molecules are still difficult to prepare with high efficiency and selectivity. Successful execution of the aims of this research program should deliver novel molecules with unusual structures and promising biological profiles and the discovery of new methods useful for preparing compounds with pharmaceutical potential.

PI_NAMEs: FRONTIER, ALISON J (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Iterative Cyclization Strategies for Complex Molecule Synthesis

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: NARRATIVE The recent pandemic has revealed the critical need for cost-effective and sensitive point-of-need testing for infectious diseases. Our objective is to develop an adaptable and deployable sensing platform for multiplexed genetic biomarker detection in liquid biopsies. Our approach is to use machine learning for adaptable sensor design combined with the lyophilization and tableting or reagentless sensors for improved applicability.

PI_NAMEs: STROBBIA, PIETRO  (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: 2019-nCoV;Address;Algorithm Design;Algorithms;Biological Assay;Biological Markers;Biosensor;Catalysis;clinical practice;clinically relevant;communicable disease diagnosis;Communicable Diseases;Computer Models;Containment;cost effective;cost effectiveness;COVID-19 detection;COVID-19 pandemic;current pandemic;Data Set;Decentralization;design;Detection;detection limit;Development;Devices;Diagnostic;diagnostic accuracy;Diagnostic Procedure;Diagnostic tests;Disease;Disease Surveillance;DNA;DNA Sequence;Ensure;Exhibits;Freeze Drying;Genetic Code;Genetic Markers;Goals;improved;Infection;insight;Knowledge;lateral flow assay;liquid biopsy;Machine Learning;Methods;Molecular;Molecular Diagnostic Testing;multiplex assay;Multivariate Analysis;novel;open source;Outcome;pandemic disease;pathogen;Performance;plasmonics;Polymerase Chain Reaction;portability;Procedures;Process;prognostic;Readiness;response;Saliva;saliva sample;Sampling;SARS-CoV-2 variant;Sensitivity and Specificity;sensor;standard care;Surface;System;Tablets;Techniques;Testing;Thermodynamics;Variant;Viral;Viral Load result;Virus

PROJECT_TITLE: Designing a deployable and adaptable plasmonic sensing platform for infectious disease surveillance

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Services;Prevention;Primary Health Care

ORG_CITY: KANSAS CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative While effective colorectal cancer (CRC) screening interventions have been tested that use state-of-the art technology and behavior change theory, their implementation into routine primary care settings, and how this works best in different contexts, remains to be tested. This parallel cluster randomized study will test at scale an intervention we have piloted successfully: NPT-PLA, an intervention uses an implementation science framework (normalization process theory -NPT) to inform a participatory health research approach: Participatory Learning in Action (PLA) (10 clinics) vs `usual quality improvement (control) (10 clinics). The goal will be to learn which approach works best to integrate into routine primary care delivery a proven decision- making tool (“I2”) that helps patients choose “how” and “when” to screen; and to translate this into CRC screening completion — providing vital information regarding the effectiveness and utility of NPT-PLA in the context of cancer screening.

PI_NAMEs: GREINER, K ALLEN;HESTER, CHRISTINA MARIE;LEMASTER, JOSEPH W (contact)

PROGRAM_OFFICER_NAME: KOBRIN, SARAH

PROJECT_TERMS: Academy;Address;American;arm;behavior change;Cancer Etiology;care delivery;Caring;Cessation of life;Clinic;Clinical;clinical care;clinical practice;Cluster randomized trial;Collaborations;Colonoscopy;Colorectal Cancer;colorectal cancer screening;Communities;comparative;Complex;Comprehension;Creativeness;Decision Making;Effectiveness;effectiveness testing;Elements;Eligibility Determination;Enrollment;experience;Exposure to;Face;Family Physicians;Focus Groups;follow-up;Funding;Future;Goals;Health;health care service organization;health care settings;Human Resources;implementation barriers;implementation evaluation;implementation framework;implementation intervention;implementation process;implementation science;improved;Intention;International;Intervention;Language;Learning;Limited English Proficiency;Maintenance;member;Methodology;Methods;multidisciplinary;novel;Outcome;Paper;Pathway interactions;patient engagement;patient population;Patients;Persons;Population;practice setting;Primary Care;primary care clinic;primary care clinician;primary care practice;primary care setting;Problem Solving;Process;process improvement;Randomized;Research;resilience;Role;screening;Screening for cancer;Screening procedure;Shapes;shared decision making;Site;social culture;Sociology;Spanish;Spanish/English;stool sample;Surveys;Technology;Testing;theories;Theory of Change;tool;Translating;treatment arm;treatment as usual;trial design;Trust;uptake;Voice;Work

PROJECT_TITLE: PB-iCRC: Multi-site Practice-Based Implementation of a ColoRectal Cancer screening intervention

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project narrative Measles remains one of the 10 most important causes of infectious disease death due to inadequate population coverage with the live attenuated virus vaccine. The vaccine is safe, effective, and is being modified to produce new vaccines and cancer treatments, but the molecular bases of vaccine attenuation and the biological differences between vaccine and virulent wild type strains of measles virus have never been defined. This project will identify how the attenuated virus differs from wild type measles virus with respect to infection of immune cells, infection of non-human primates, long term effects on the immune system and stimulation of a protective immune response.

PI_NAMEs: GRIFFIN, DIANE E (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acceleration;Acute;adaptive immune response;Affect;Agonist;Anti-viral Therapy;Antibodies;Antibody Diversity;Antibody Formation;Antibody titer measurement;Attenuated;Attenuated Live Virus Vaccine;Attenuated Vaccines;attenuation;Autopsy;Avidity;base;Biological;Biology;Blood;Bone Marrow;Bone Marrow Cells;cancer therapy;Cell Survival;cell type;Cells;Cessation of life;Chicken Cells;Child;Child Mortality;Communicable Diseases;COVID-19 pandemic;cytokine;Development;Epithelial Cells;Exanthema;Experimental Autoimmune Encephalomyelitis;Flow Cytometry;Genetic Polymorphism;Hemagglutinin;Immune;immune activation;Immune response;Immune system;Immunity;Immunization;Immunoglobulin-Secreting Cells;Immunohistochemistry;Immunologic Stimulation;Immunologics;Immunosuppression;Impairment;In Situ Hybridization;in vivo;Infection;Knowledge;Licensing;Long-Term Effects;Longitudinal Studies;Lymphocyte;Lymphoid Tissue;Macaca;Macaca mulatta;Maps;Measles;Measles Vaccine;Measles virus;Modeling;Molecular;monocyte;Myeloid Cells;nonhuman primate;novel vaccines;Oncolytic;pathogen;Peptides;Peripheral Blood Mononuclear Cell;Physiological;Plasma;Polymerase;Population;Post-Translational Protein Processing;Predisposition;Production;Protein Biosynthesis;Proteins;Recombinants;remdesivir;Respiratory System;response;reverse genetics;RNA;RNA chemical synthesis;RNA Polymerase Inhibitor;RNA Viruses;Safety;single-cell RNA sequencing;Site;Specificity;Structure of germinal center of lymph node;T-Lymphocyte;Time;Tissues;TLR2 gene;Urine;Vaccines;vector vaccine;Viral;viral RNA;Virulent;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Immunological and Physiological Responses to Measles Vaccine

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Narrative Dinuclear monooxygenases play essential roles in microbial metabolism and bioactive natural product formation. While many of these enzymes are thought to utilize di-iron cofactors to activate the strong carbon-hydrogen bonds of the cognate substrate, our group has recently characterized an enzyme that strictly requires formation of a mixed manganese/iron cofactor. To expand the context of this discovery and broadly understand uncharacterized monooxygenases present throughout biology, our investigation seeks to discover, characterize and understand an emergent family of manganese-dependent monooxygenases.

PI_NAMEs: RITTLE, JONATHAN D (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Active Sites;Address;Aerobic;Amidohydrolases;Amino Acid Motifs;Aminoisobutyric Acids;Anabolism;Automobile Driving;Binding Sites;bioactive natural products;Biochemical Process;Biochemistry;Bioinformatics;Bioinorganic Chemistry;Biological;Biology;Carbon;Catabolic Process;Catalysis;Cells;Chemicals;cofactor;Comparative Study;Competence;Consensus Sequence;Copper;Dedications;Diterpenes;Electron Spin Resonance Spectroscopy;Electron Transport;electronic structure;Electrons;Endowment;Enzymatic Biochemistry;enzyme model;Enzymes;Evaluation;Family;fascinate;Genomics;geometric structure;Heme;Hydrogen Bonding;Hydroxylation;in silico;in vivo;interest;Investigation;Ions;Iron;Kinetics;Manganese;Mediating;member;Metabolism;metallicity;Metals;Methods;microbial;Mixed Function Oxygenases;Molecular;Natural Products;Organism;oxidation;Oxidation-Reduction;Oxidoreductase;Oxygenases;pathogen;photosystem II;Play;preference;Process;Property;Protein Family;protein folding;Proteins;Raman Spectrum Analysis;Reaction;Research;Research Personnel;Rhodococcus;Role;spectroscopic survey;structural biology;Structure;System;Thermodynamics;Triose-Phosphate Isomerase;Water;X ray diffraction analysis

PROJECT_TITLE: Discovery and Characterization of Manganese-dependent Monooxygenases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-H (02)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Genetics;Heart Disease;Human Genome;Pediatric;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Myxomatous mitral valve prolapse, a potentially life-threatening heart valve condition, specifically affects the valve located between the left atrium and ventricle. Despite some reports on the intricate cellular environments involved, there is a notable scarcity of detailed high-resolution omics data. The objective of this project is to bridge this knowledge gap by utilizing state-of-the-art single-cell and spatial techniques to construct a comprehensive molecular atlas of the tissue affected by mitral valve prolapse.

PI_NAMEs: LIU, YANG  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Address;Affect;Antibodies;ATAC-seq;Atlases;Biological Process;Cell Communication;Cell Nucleus;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Chromatin;comparative;Comprehension;Data;Data Analyses;Databases;Disease;Disease Progression;DNA Sequence Alteration;Endothelial Cells;Environment;Epigenetic Process;epigenomics;Extracellular Matrix;Extracellular Matrix Proteins;FBN1;Gene Expression;Genes;Genetic Markers;Goals;grasp;Heart failure;Heart Valves;Heterogeneity;Immunohistochemistry;In Situ;Individual;Induced Mutation;insight;interstitial cell;Knowledge;Left atrial structure;Left Ventricular Function;Left ventricular structure;Life;Ligands;Location;Macrophage;Maps;Marfan Syndrome;Measures;Membrane Proteins;metaplastic cell transformation;Methodology;Methods;Mitral Valve;Mitral Valve Insufficiency;Mitral Valve Prolapse;Modification;Molecular;Molecular Structure;multiple omics;Onset of illness;Pathogenesis;Pathway interactions;Patients;Phosphoproteins;Play;Population;protein expression;Proteomics;Protocols documentation;receptor;Regulation;Reporting;Research;Resolution;Reverse Transcriptase Polymerase Chain Reaction;RNA;Role;Sampling;single cell sequencing;single nucleus RNA-sequencing;Subgroup;Techniques;Technology;Tissue atlas;Tissue Donors;Tissues;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta

PROJECT_TITLE: Unraveling molecular Complexity of Mitral Valve Disease using single cell and Spatial Multi-Omics analysis"

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Clinical Research;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative Babies who are born extremely prematurely suffer from bronchopulmonary dysplasia (BPD), a disease that is characterized by respiratory difficulties due to underdeveloped lungs and airways, and is responsible for $13 billion per year in healthcare costs. BPD has several different characteristics (overly dense lungs, overinflated lungs, collapse in various parts of the airway, etc.), and each characteristic may require different treatment, but understanding which characteristics are causing the respiratory difficulties in a specific patient is challenging. This study will calculate the effort that patients with BPD use to breathe (known as the work of breathing) and will determine the contribution of each characteristic of BPD to the work of breathing, revealing which character- istic(s) are the most beneficial to treat in each individual infant with BPD.

PI_NAMEs: BATES, ALISTER  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Address;Admission activity;Adrenal Cortex Hormones;Adult;Age;Air;airway obstruction;Airway Resistance;Albuterol;Alveolar;Breathing;Bronchi;Bronchodilator Agents;Bronchopulmonary Dysplasia;Caring;Characteristics;Chest wall structure;Childhood;Cicatrix;Clinical;Clinical Treatment;common treatment;Disease;disease phenotype;Distal;Dose;Drug usage;Elasticity;evidence base;extreme prematurity;Fibrosis;Future;Goals;Health;Health Care Costs;improved outcome;Individual;individualized medicine;Infant;Inflammation;innovation;Intervention;laryngomalacia;Liquid substance;Location;Lung;Lung Compliance;Lung Diseases;lung imaging;lung pressure;Lung Volume Measurements;Magnetic Resonance Imaging;Measures;Medical center;Medicine;Membrane;Methods;Modeling;Neonatal;Neonatal Intensive Care Units;neonate;novel;Obstruction;Pathology;patient response;Patients;Pediatric Hospitals;personalized care;personalized diagnostics;Phenotype;Population;precision medicine;Pregnancy;Premature Birth;Premature Infant;preterm newborn;Reader;reconstruction;Relaxation;Research;Resistance;Respiration;respiratory;Respiratory Airflow;Respiratory Disease;Respiratory distress;response;Risk;Severity of illness;simulation;Site;Smooth Muscle;Specific qualifier value;Steroids;Structure of parenchyma of lung;Symptoms;Techniques;Tissues;Titrations;tool;Trachea;Tracheobronchomalacia;tracheomalacia;Translating;Trees;United States;Work;Work of Breathing

PROJECT_TITLE: Calculating the Components of Work of Breathing in Neonates with Bronchopulmonary Dysplasia


ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: Project Narrative The proposed research is of high relevance to Public Health because it aims to understand and control melanoma progression and therapy resistance, and to discover potential new targets to guide the personalized treatment of a disease of unmet need. The successful completion of the proposed project will elucidate new mechanisms underpinning melanoma-associated phenotypic switch, providing the molecular basis for targeting tumor plasticity to increase the efficacy of current melanoma therapies.

PI_NAMEs: LIANG, CHENGYU  (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Address;Behavior;Biological Assay;BRAF gene;Cell Differentiation process;Cell Line;Cells;Cellular Stress;Clinical;Complex;Data;Dependence;Development;dimensional analysis;Disabling;Disease;Disease Outcome;Disease remission;driver mutation;Drug resistance;Family;gain of function;Genes;Genetic;Genetic Determinism;Genetic Transcription;Genetically Engineered Mouse;Genomic approach;Genomics;Heterogeneity;high dimensionality;Human;Immune;Immune Evasion;Immunologist;Immunotherapeutic agent;Immunotherapy;improved;in vivo;insight;Investigation;Lesion;loss of function;Malignant Neoplasms;Mediating;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;member;Metastatic Melanoma;Modeling;Molecular;molecular targeted therapies;mouse model;multidisciplinary;Mutation;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Oncogenes;Oncogenic;Pathogenesis;Pathologist;Pathway interactions;patient derived xenograft model;Patients;Pattern;personalized medicine;Phenotype;Phosphorylation;Pigments;Play;Prevention;Primary Neoplasm;Process;programs;Public Health;Recurrence;Relapse;Repression;Research;Resistance;Resistance development;response;restoration;Role;Sampling;Shapes;Signal Transduction;single molecule;Skin Cancer;Structure;Survival Rate;Testing;Therapeutic;transcription factor;Transcriptional Regulation;transcriptional reprogramming;transcriptomics;Transforming Growth Factor beta;Translating;tumor;tumor heterogeneity;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Suppression;tumor-immune system interactions;Tumor-infiltrating immune cells;Up-Regulation;Work

PROJECT_TITLE: Transcriptional Reprogramming in Melanoma Plasticity

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Lung;Organ Transplantation;Prevention;Transplantation

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE The proposed project aims to provide new insights and early detection tools into Acute Cellular Rejection (ACR), a major risk factor for developing chronic allograft failure after lung transplantation. We propose to deploy new imaging approaches to diagnose ACR early so that it can be managed more effectively for better outcomes.

PI_NAMEs: MATA, JAIME  (contact);SHIM, YUN MICHAEL

PROGRAM_OFFICER_NAME: CHARYA, ANANTH VELUGALETI

PROJECT_TERMS: Acute;Address;Aftercare;Agreement;Air Movements;Algorithms;allograft rejection;Allografting;Anatomy;Area;Biopsy;Bronchoalveolar Lavage Fluid;Bronchoscopy;Categories;Cells;Cessation of life;Chest;Chronic;Clinical;clinical diagnosis;clinical diagnostics;Clinical Management;Clinical Pathology;Data;Detection;Diagnosis;diagnostic accuracy;Diagnostic Procedure;Early Diagnosis;Evaluation;Evolution;experience;Failure;follow-up;Functional disorder;Gases;graft failure;imaging approach;Immune response;Immunologics;immunopathology;insight;Left;Lobe;Lung;lung allograft;Lung Diseases;Lung Transplantation;Magnetic Resonance Imaging;Maps;Methods;Molecular;molecular phenotype;Morbidity - disease rate;mortality;novel diagnostics;Outcome;Pathologic;Pathology;patient population;Patients;Performance;performance tests;Physiological;Physiology;prevent;Prognosis;Pulmonary function tests;Reporting;Resolution;response;Risk Factors;RNA Sequences;Sampling;single-cell RNA sequencing;Testing;Tissues;tool;transcriptome;transcriptomics;Transplant Recipients;Transplantation;transplantation medicine;treatment optimization;Visit;X-Ray Computed Tomography;Xenon

PROJECT_TITLE: Developing Hyperpolarized Gas MRI signatures to detect and manage acute cellular rejection

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: LM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: HAYS

ORG_NAME: FORT HAYS STATE UNIVERSITY

PHR: Project Narrative The project aims to develop novel software tools for the quality assessment of the tens of thousands of organelle genomes archived on the nucleotide sequence database GenBank. The tools will enable scientists from various areas of biomedical research to make informed, evidence-based decisions on the reuse of complete organelle genomes and to compile only secure, curated genome sets. The project advances the goal of making high-quality genomic data assets identifiable to the biomedical research community.

PI_NAMEs: GRUENSTAEUDL, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: analysis pipeline;annotation  system;Archives;Area;automated analysis;Base Sequence;bioinformatics tool;Biomedical Research;Communities;Computer software;Computer Systems;computerized tools;Computing Methodologies;Data;data mining;data quality;Data Set;Databases;Development;Discipline;Environmental Health;evidence base;Exhibits;flexibility;Forensic Medicine;Genbank;Genes;Genome;genomic data;Genomics;Goals;Housekeeping Gene;Human;Human Genetics;improved;Individual;Information Retrieval;Institution;Investigation;Language;Link;Literature;Measures;Metadata;Methods;Microbiology;Mitochondria;mitochondrial genome;Modernization;Modification;molecular sequence database;novel;open source;Organelles;Plastids;PubMed;Records;reference genome;Research;Research Personnel;Science;Scientist;Secure;software development;Software Tools;Standardization;Students;Testing;Text;tool;tool development;Toxicology;Training;undergraduate student;user-friendly;virtual;Visualization;Writing

PROJECT_TITLE: Enabling data quality assessment of organelle genomes archived on GenBank through novel open-source software tools

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 AS-C (01)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Acute pancreatitis is a prevalent gastrointestinal disorder that imposes a substantial burden on healthcare systems due to its high hospitalization rates and associated costs, with limited effective therapies currently available, there is an urgent need for research aimed at developing successful treatments. This research proposal aims to dissect the roles of trypsin and coagulation in acute pancreatitis and test the hypothesis that thrombin plays a crucial role in the development of the disease, particularly by influencing the microenvironment through its PAR receptors. By utilizing various models, inhibitors, and imaging technology, this project aims to advance our understanding of the pathophysiology of acute pancreatitis and contribute to the development of targeted therapies.

PI_NAMEs: BI, YAN  (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: acute pancreatitis;Address;Affect;Animal Model;Animals;Anticoagulation;Blood flow;cell injury;Cells;Clinical Trials;Coagulation Process;combat;cost;Death Rate;design;Development;Disease;Drug Delivery Systems;Drug Modelings;effective therapy;Endothelial Cells;Engineering;Exhibits;Exposure to;F2R gene;Failure;Formulation;Foundations;Functional disorder;Future;gastrointestinal;Gastrointestinal Diseases;Genes;Genetic;genetic approach;Genetic Models;Health Care Costs;Healthcare Systems;Hospitalization;hospitalization rates;Human;imaging system;Imaging technology;improved;In Vitro;Inflammatory;inhibitor;Inpatients;Intravenous;intravital imaging;Knockout Mice;Knowledge;Lead;local drug delivery;Location;Microcirculation;Modeling;Monitor;mouse model;multi-photon;Mus;novel;Outcome;Pancreas;Pancreatic enzyme;Pancreatitis;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Play;Pre-Clinical Model;prevent;Prevention;Prodrugs;protein expression;Protein Isoforms;receptor;recruit;Research;Research Proposals;Role;Safety;Severities;Site;Solid;targeted treatment;Testing;therapeutic evaluation;Thrombin;Time;Tissues;Transgenic Mice;Treatment Efficacy;Trypsin;Trypsin Inhibitors;Work

PROJECT_TITLE: Deciphering Pancreatitis Microenvironment through Intravital Imaging

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Chronic infections and cancer result in dysfunction of immune cells, termed “exhaustion”. With this proposal, we will investigate the cellular and molecular mechanisms that cause exhaustion and the use of a small non-coding RNA (microRNA-29a; miR-29a) to overcome exhaustion. We will explore the potential of delivering miR-29a to T cells as a novel strategy to improve responses to immunotherapy.

PI_NAMEs: STELEKATI, ERIETTA  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: anti-PD-L1;anti-PD-L1 therapy;Antigens;Attenuated;Cancer Etiology;CD8-Positive T-Lymphocytes;Cells;Cellular biology;Characteristics;checkpoint therapy;Chronic;chronic infection;Data;demethylation;DNA;DNA Methylation;Ectopic Expression;Enzymes;Epigenetic Process;epigenetic regulation;epigenome;exhaust;exhaustion;experience;functional improvement;Gene Modified;Generations;Genetic Transcription;Goals;Immune checkpoint inhibitor;Immune response;Immune System Diseases;Immunologics;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;Infection;innovation;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Melanoma;Memory;MicroRNAs;Modeling;Molecular;mouse model;novel;novel strategies;overexpression;Pathway interactions;Patients;progenitor;Reporting;Repression;Resistance;response;Role;stem;stem cell differentiation;success;synergism;System;T cell differentiation;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Testing;tumor;Untranslated RNA;Viral;Virus Diseases

PROJECT_TITLE: Epigenetic regulation of exhausted CD8 T cells via the miR-29a-TET2 axis

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  Among patients with hematologic malignancy, reported beta-lactam (BL) allergy is associated with excessive antibiotic use and negative clinical outcomes, likely because patients with a BL allergy label more often receive antibiotic therapy that is less effective, overly broad, and/or more toxic. For the great majority of people, reported BL allergies are mischaracterized or have been outgrown. This study will test a novel intervention to assess and, if appropriate, delabel BL allergy in patients hospitalized with hematologic malignancy and determine the effect of this intervention on subsequent antibiotic use and clinical outcomes.

PI_NAMEs: LAUTENBACH, EBBING  (contact);SZYMCZAK, JULIA E.

PROGRAM_OFFICER_NAME: HENDERSON, SUSAN

PROJECT_TITLE: Optimizing antibiotic selection in hematologic malignancy patients with reported beta-lactam allergy

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Gene Therapy;Genetics;Orphan Drug;Pediatric;Rare Diseases;Regenerative Medicine

ORG_CITY: DAVIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: The overarching goal of these studies is to develop and implement tools and technologies to ensure rigor and reproducibility of translational nonhuman primate models for precision genetic and regenerative medicine therapeutics. These studies incorporate highly sensitive in vivo imaging technologies with correlative methods focused on the immune system to ensure preclinical studies are predictable and provide essential information for human translation across age groups.

PI_NAMEs: HARTIGAN-O'CONNOR, DENNIS J.;TARANTAL, ALICE F (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Adolescent;Adverse event;Age;age group;Anatomy;Animal Experimentation;Animals;Biodistribution;Biological Models;Blood;Brain;Cells;Clinic;clinical translation;Dependovirus;Detection;Disease;draining lymph node;Engineering;Ensure;fetal;Flow Cytometry;Future;Gene Expression;gene therapy;Gene Transfer;Genetic;Genetic Medicine;Genetic Models;Goals;Health;Human;Image;Imaging Techniques;Imaging technology;Immune response;Immune system;Immunity;Immunologics;Immunology;Immunophenotyping;improved;in utero;in vivo;in vivo imaging;Inflammation;innovation;Innovative Therapy;insight;intrahepatic;Intraventricular;Investigation;Kidney;life span;Liver;Macaca mulatta;Measures;Methods;minimally invasive;Modeling;Monitor;nonhuman primate;novel therapeutics;Organ;Outcome;Positron-Emission Tomography;postnatal;pre-clinical;precision genetics;preclinical study;Pregnancy;prenatal;Primates;Proteins;protocol development;Protocols documentation;Rare Diseases;Regenerative Medicine;regenerative therapy;Reproducibility;Resources;response;Safety;Sampling;Site;somatic cell gene editing;Specificity;T cell infiltration;T-Cell Activation;T-Lymphocyte;targeted delivery;Technology;Therapeutic;therapeutic gene;Tissues;tool;transgene expression;Translational Research;translational study;Translations;ultrasound;vector;Viral Vector

PROJECT_TITLE: Enhancing Rigor and Reproducibility of Translational Nonhuman Primate Models for Genetic and Regenerative Therapies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-J (55)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: Older Veterans with serious mental illness (SMI; schizophrenia-spectrum and bipolar disorders) have reduced physical function (i.e., strength, mobility, endurance) that leads to more falls, hospitalizations, and nursing home admissions. Exercise improves physical function in older Veterans; however, environmental difficulties (e.g., lack of transportation), low motivation from mental health symptoms, and comorbid medical issues make participation in facility-based exercise programs challenging for older Veterans with SMI. This CDA-2 will develop, refine, and feasibility test a home-based exercise program for older Veterans with SMI that targets the established barriers impacting exercise engagement in this population. This study will result in the first exercise program designed specifically to improve strength, mobility, and endurance in older Veterans with SMI. This work has the potential to improve the physical and mental health, quality of life, and independence of a population at tremendous risk for functional decline.

PI_NAMEs: BROWNE, JULIA  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Admission activity;Adult;Affect;Age;Area;Award;base;Behavior Therapy;Bipolar Disorder;Body Weight decreased;burden of illness;Cardiac;Cardiac rehabilitation;career;career development;Career Mobility;Cladribine;Clinical;Clinical Research;Clinical Trials Design;cohort;comorbidity;design;Dropout;Enrollment;Evaluation;Exclusion;Exercise;exercise adherence;exercise intervention;exercise prescription;exercise program;experience;falls;Feasibility Studies;feasibility testing;Feedback;follow-up;Foundations;functional decline;functional improvement;functional independence;Goals;Health;Health education;Health Promotion;Home;Hospitalization;improved;Individual;Intervention;K-Series Research Career Programs;Leadership;Life Expectancy;life span;Manuals;Medical;Mental Depression;Mental Health;Mentorship;Methods;Modality;Modeling;Monitor;mortality;Motivation;neglect;Nursing Homes;Occupational;older adult;Older Population;Personal Satisfaction;Phase;physical conditioning;Physical Exercise;Physical Function;Population;population based;Predisposition;primary outcome;Problem Solving;Procedures;Program Acceptability;programs;psychologic;psychosocial;Qualitative Methods;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Research;Research Personnel;Risk;Schizophrenia;secondary outcome;severe mental illness;sex;social;stem;Symptoms;Telephone;telephone coaching;Testing;therapy development;Training;Transition Career Development Award (K22);Transportation;transportation access;Veterans;walking intervention;Work

PROJECT_TITLE: A Feasibility Study of Home-based Exercise for Older Veterans with Serious Mental Illness

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Food Allergies;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The IgE antibody provides the antigen specificity for the type 2 immune effector cells it arms, mast cells, basophils, and eosinophils, plays a causal role in allergy, and remains understudied for its fundamental function in defending us against parasites. It has recently been determined that type 2 immunity plays a critical role in an immune phenomenon known as acquired tick resistance, where tick feeding is disrupted by the host immune response, reducing transmission of tick- borne pathogens. Studying tick specific IgE monoclonal antibodies, derived from people who have repeated tick bites and/or alpha-gal syndrome, will allow for the most basic and critical immunologic interactions to be assessed between the human IgE antibody response and tick antigens and will provide new insights into the often pathological but potentially protective aspect of the human adaptive immune system.

PI_NAMEs: SMITH, SCOTT ALAN (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Adaptive Immune System;Allergic;Allergic Disease;Allergic Reaction;alpha-gal syndrome;Ambylomma americanum;Amines;Anaphylaxis;Animal Experiments;Antibodies;Antibody Response;Antigen Presentation;Antigen Targeting;Antigens;arm;B-Lymphocytes;Basophils;Binding;Biological Markers;Bite;Black-legged Tick;Cells;Clone Cells;cohort;Control Animal;Coupling;crosslink;Data;Development;Diagnostic;Disease;Effector Cell;Enzyme-Linked Immunosorbent Assay;eosinophil;Epitopes;Escherichia coli;Evaluation;experimental study;exposed human population;Exposure to;feeding;Foundations;Generations;Glycoproteins;Helminths;Histologic;Human;human disease;human monoclonal antibodies;human subject;Hybridomas;Hypersensitivity;IgE;Immobilization;Immune;Immune response;Immune Targeting;Immunity;Immunologics;Immunoprecipitation;in vivo;Individual;Infection;Infiltration;insight;Institutional Review Boards;Interruption;Livestock;Mass Spectrum Analysis;mast cell;Measurement;Measures;Mediating;Mediator;Memory B-Lymphocyte;memory encoding;Methods;Modeling;Monoclonal Antibodies;mouse model;Mus;Natural Immunity;novel;Outcome;Parasites;pathogen;Pathogenesis;Pathologic;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Play;Polysaccharides;Proteins;Proteomics;Reaction;receptor;Recombinants;Recording of previous events;recruit;Recurrence;Research Subjects;Resistance;Role;Salivary;Salivary Proteins;Serum;Site;Specificity;success;superparamagnetism;Techniques;Technology;Testing;Therapeutic Uses;tick bite;tick feeding;tick saliva;tick transmission;Tick-Borne Diseases;tick-borne pathogen;Ticks;Time;Tissues;tool;transmission process;Vaccination;Western Blotting;Work;wound

PROJECT_TITLE: Role of IgE in human disease and immunity to ticks

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Neuroblastoma;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative. The MYC family of transcription factors (TF) are notorious drivers of many cancers but have been resistant to traditional drug discovery strategies. To address this challenge, we have developed a new type of molecule, synthetic transcriptional repressors (STRs)m that specifically bind to the same DNA sequences as MYC proteins, thereby inhibiting MYC function in cancer cells. Here, we will develop next-generation STRs with improved biochemical and pharmacological properties and test their ability to block MYC-dependent gene expression and cell growth in cellular and animal models of cancer.

PI_NAMEs: MOELLERING, RAYMOND E (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Address;Affinity;analog;Animal Cancer Model;Animal Model;Animals;antagonist;Architecture;base;BHLH Protein;Binding;Binding Proteins;Biochemical;Biological Assay;c-myc Genes;cancer cell;Cancer cell line;Cell Cycle Progression;cell growth;Cell model;Cells;Chemicals;ChIP-seq;Clinical;Collaborations;Coupled;Data;design;Development;dimer;Disease;DNA Binding;DNA Binding Domain;DNA Sequence;DNA-Protein Interaction;drug development;drug discovery;Drug Targeting;E-Box Elements;efficacy study;efficacy testing;Enhancers;Epigenetic Process;epigenetic profiling;Evaluation;Exhibits;Family;Family member;flexibility;Future;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Generations;Genes;Genetic Transcription;Genome;Goals;Helix-Turn-Helix Motifs;Human;Immune Evasion;Immunotherapy;improved;in vivo;in vivo imaging;in vivo Model;inhibitor;insight;Invaded;Laboratories;Lead;Liquid substance;Literature;Lymphoma;Malignant Neoplasms;Maps;MAX gene;Mediating;Metabolism;meter;mimetics;mimicry;Modification;monomer;mouse model;Mutate;MYC Family Protein;Nature;Neoplasm Metastasis;neoplastic cell;Neuroblastoma;next generation;novel;Oncogenic;Penetration;Peptides;pharmacologic;Pharmacology;Phenotype;Primary Neoplasm;Process;programs;promoter;Property;Protein Biosynthesis;Proteins;Proto-Oncogene Proteins c-myc;quantitative imaging;rational design;recruit;Regulator Genes;Reporting;residence;Resistance;Route;scaffold;self assembly;Services;Signal Transduction;Site;small molecule inhibitor;Solid Neoplasm;Specificity;Structure;Synthesis Chemistry;targeted treatment;Testing;Therapeutic;therapeutic target;three dimensional structure;Time;trafficking;transcription factor;Transcription Repressor;Transcriptional Regulation;transcriptional reprogramming;transcriptomic profiling;transcriptomics;Translations;tumor;tumor growth;Up-Regulation;uptake;Work

PROJECT_TITLE: Direct Targeting of MYC in Cancer with Hyperstable Synthetic Transcriptional Repressors

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: BROWN UNIVERSITY

PHR: Project Narrative Innate recognition and control of enteric viral infection in the intestinal epithelium is understudied. This proposal seeks to determine how viral infection is sensed by cellular innate sensing pathway and how virus counteracts to the immunity using a murine norovirus model.

PI_NAMEs: LEE, SANGHYUN  (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Binding;Cell Line;Cell surface;Cell Surface Proteins;Cells;CRISPR-mediated transcriptional activation;enteric virus infection;Enterocytes;Epithelial Cells;Heparitin Sulfate;Immune Evasion;Immunity;improved;Infection;insight;Interferon Receptor;Interferons;intestinal epithelium;Intestines;Mediating;Membrane Proteins;Microbe;Modeling;Molecular;Molecular Target;mouse model;Mus;Norovirus;novel;pathogen;Pathogenicity;Pathway interactions;Pattern;Physiological;Play;Production;receptor;Recombinants;Regulation;Research;Research Proposals;response;RNA Virus Infections;Role;Science;screening;sensor;Signal Transduction;Signaling Molecule;Specificity;syndecan-4;Techniques;Therapeutic;therapeutic development;Tissues;Viral;Viral Proteins;viral RNA;Virus;Virus Diseases;virus host interaction

PROJECT_TITLE: Viral immune evasion during intestinal norovirus infection

STUDY_SECTION: VDT

STUDY_SECTION_NAME: Viral Dynamics and Transmission Study Section [VDT]


NIH_SPENDING_CATS: Diabetes

ORG_DEPT: SURGERY

PHR: We have identified the signaling protein, 14-3-3ζ, as a novel regulator of β-cell function and crosstalk between α-cells and β-cells. The goal of this proposal is to determine how α-cells contribute to β-cell 14-3-3ζ regulation of GSIS and how β-cell 14-3-3ζ regulates α-cell endocrine profile.

PI_NAMEs: CUMMINGS, BETHANY PAIGE (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Ablation;Alpha Cell;Beta Cell;blood glucose regulation;Cell Physiology;Chemosensitization;Complex;Data;Disinhibition;Down-Regulation;Endocrine;Functional disorder;Genetic Transcription;GLP-I receptor;Glucagon;Glucagon Receptor;glucagon-like peptide 1;Glucose;glucose production;Goals;Health;Hepatic;Heterogeneity;Hormones;Human;improved;inhibitor;insight;insulin secretion;islet;Islet Cell;Islets of Langerhans;Knockout Mice;Mediating;Metabolic stress;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Output;paracrine;Pathogenesis;Pathway interactions;Play;Prevention;Production;proglucagon;receptor;Receptor Signaling;Recommendation;Regulation;response;Role;Signaling Protein;Stimulus;Testing;Text;Wild Type Mouse;Work

PROJECT_TITLE: 14-3-3-zeta regulation of islet health

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke;Telehealth

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Dysphagia, or difficulty swallowing, is a common symptom of many neurological diseases but its treatment is not well established or easily accessible. We will systematically examine the comparative efficacy of using a new portable electromyography biofeedback device we have developed as adjunct to a standardized swallow therapy protocol – delivered in-person and via telehealth – in improving health outcomes in patients with stroke or Parkinson’s disease, and determine what patient factors may influence response to treatment; thus, the proposed research is relevant to public health and in line with NIH’s mission to improve the evidence base and accessibility of efficacious rehabilitation strategies for this debilitating health condition.

PI_NAMEs: MALANDRAKI, GEORGIA  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Adherence;Adult;Affect;Age;Behavior Therapy;Behavioral;Biofeedback;Cause of Death;chronic stroke;Clinic;Clinical;clinical center;Clinical Data;Clinical Research;common symptom;comparative efficacy;comparative safety;cost effective;Dangerousness;Data;Deglutition;Deglutition Disorders;design;Development;Devices;Diagnosis;Disease;Disease Management;Disparity;effectiveness trial;efficacy evaluation;electromyographic biofeedback;Electromyography;Endoscopy;evidence base;Examinations and Diagnoses;Exercise;Funding;Future;Goals;Head and Neck Muscle;Head and neck structure;Health;health care delivery;health disparity;Home;improved;indexing;Intervention;Life;Lung infections;Malnutrition;Manometry;Mission;mortality;Muscle;National Institute of Biomedical Imaging and Bioengineering;Nervous System Disorder;Neurologic;neuromuscular activity;neurophysiology;novel;Oropharyngeal;Outcome;Parkinson Disease;Patient-Focused Outcomes;Patients;Personal Satisfaction;Persons;Physiological;Physiology;Population;portability;predicting response;Protocols documentation;Public Health;Quality of life;Randomized;randomized, clinical trials;rehabilitation service;rehabilitation strategy;Rehabilitation therapy;Research;Respiratory Tract Infections;Role;rural area;Safety;satisfaction;sensor technology;Severity of illness;standard of care;Standardization;Stroke;Surface;telehealth;telehealth systems;telerehabilitation;Translating;treatment group;treatment response;United States National Institutes of Health;wearable device;Work

PROJECT_TITLE: Impact of wearable biofeedback for the rehabilitation and tele-rehabilitation of neurogenic dysphagia

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Normothermic Regional Perfusion (NRP) is a novel organ preservation method with the potential to vastly increase the number of high quality hearts and other organs available for over 100,000 people with end-stage organ failure in the United States waitlisted for transplant. But NRP is the subject of great ethical controversy because it requires restarting circulation inside the donor’s body, which might challenge the determination of the donor’s death. This project aims to assess the potential impact of NRP on public trust in the U.S. organ transplantation system to inform how organ procurement organizations talk to families about NRP, and inform whether transplant programs participate in NRP.

PI_NAMEs: PARENT, BRENDAN  (contact)

PROGRAM_OFFICER_NAME: FENTON, KATHLEEN NELLE

PROJECT_TERMS: Adopted;Affect;Age;Attention;Attitude;Authorization documentation;Belief;Blood;Blood Circulation;Cessation of life;Circulation;Collaborations;Consensus;Data;Determination of Death;Eligibility Determination;end-stage organ failure;Engineering;Ensure;Ethicists;Ethics;Extracorporeal Membrane Oxygenation;Family;Family member;Focus Groups;Gender;Guidelines;Heart;Heart failure;heart function;Heart Transplantation;In Situ;Individual;Injury;innovation;Interview;Ischemia;ischemic injury;Lawyers;Life;Longevity;loved ones;Medicine;Methods;Modeling;Neurologic;novel;Operative Surgical Procedures;Organ;Organ Donations;Organ Donor;organ injury;Organ Preservation;Organ Procurements;Organ Transplantation;Outcome;Participant;Patients;Perception;Perfusion;Persons;Physician Executives;Process;programs;Protocols documentation;Public Opinion;public trust;Race;Regional Perfusion;Religion;Research;Resources;Respiratory physiology;Risk;Scanning;Social Workers;sound;Standardization;Surveys;System;Techniques;Technology;Time;Training;Transplantation;Trust;United States;United States National Academy of Sciences;Waiting Lists

PROJECT_TITLE: Investigating Donor Authorization and Public Perceptions of Normothermic Regional Perfusion to Inform Ethical Organ Donation Practices

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Immunotherapy;Pediatric;Prevention

PHR: PROJECT NARRATIVE This research aims to enhance our understanding of the metabolic benefits of glucagon-like peptide-1 receptor agonists (GLP-1Ra) in stage 2 type 1 diabetes patients treated with teplizumab. By investigating the insulinotropic and glucagonostatic effects of GLP-1Ra, the study seeks to improve treatment outcomes, slow disease progression, and enhance the quality of life for individuals with type 1 diabetes. The insights gained will have broad implications for the management of diabetes, a major public health concern, contributing to strategies that can extend healthy life and reduce illness.

PI_NAMEs: GREGORY, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Address;Affect;Agonist;Beta Cell;Biological Assay;C-Peptide;cardiometabolism;Cell Physiology;Clinic;Clinical;clinical practice;Clinical Trials;Combined Modality Therapy;Compensation;Cross-Over Studies;Crossover Design;Data;Data Analyses;design;Development;diabetes management;Disease;Disease Progression;Double-Blind Method;Early treatment;effective therapy;Elements;Endoplasmic Reticulum;Endothelial Cells;Endothelium;exenatide;experience;Feasibility Studies;feasibility trial;Functional disorder;Funding;Future;GLP-I receptor;Glucagon;Glucose;Goals;Haplotypes;hyperglucagonemia;Hyperglycemia;immunomodulatory therapies;immunoregulation;Immunotherapy;improved;indexing;Individual;innovation;insight;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;interest;Intervention;Islet Cell;Knowledge;Life;Linear Regressions;Measures;Mediating;Metabolic;Metabolism;Mission;Modeling;Monoclonal Antibodies;National Institute of Diabetes and Digestive and Kidney Diseases;Nitric Oxide;Non-Insulin-Dependent Diabetes Mellitus;novel;Oral;Outcome;Patient-Focused Outcomes;Patients;personalized medicine;Pilot Projects;pilot trial;Placebo Control;Placebo Effect;Population;primary outcome;Process;Proinsulin;Property;Public Health;Quality of life;Randomized;recruit;Regression Analysis;Research;Research Design;response;Role;slow potential;stem;Structure;Testing;Therapeutic;Treatment outcome;treatment strategy;ultrasound;Vascular Diseases;Vasodilation;volunteer

PROJECT_TITLE: Optimizing Stage 2 T1DM Management: Assessing the Impact of GLP-1Ra on Metabolic Outcomes in Patients Receiving Teplizumab

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Primary Health Care;Rare Diseases;Tuberculosis

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Development of non-sputum, biomarker-based tests to diagnose tuberculosis (TB) disease, assess disease severity, and monitor responses to treatment would allow clinicians in low-resource, primary care settings to more easily detect TB cases and employ a precision medicine approach to TB treatment. Key knowledge gaps standing in the way of developing rapid, point-of-care tests for TB disease diagnosis and management include a lack of blood-based biomarkers of TB disease and treatment response. This research project will discover immunometabolic plasma biomarker signatures able to identify TB disease and predict TB clearance with potential for translation to point-of-care tests to improve TB diagnosis and treatment outcomes.

PI_NAMEs: COLLINS, JEFFREY M (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: 12-HETE;Address;Adult;Bioinformatics;Biological Assay;Biological Markers;biological specimen archives;Biological Testing;biomarker development;biomarker identification;biomarker signature;Blood;Blood specimen;blood-based biomarker;care seeking;Catabolism;chest computed tomography;Chest imaging;Classification;Clinical;Clinical Data;clinical predictors;cohort;Collaborations;Communities;Control Groups;cost;Country;cytokine;Data;design;Detection;Development;Diagnosis;Diagnostic;Disease;disease diagnosis;Disease Management;Enrollment;Evaluation;Exclusion;follow-up;Funding;Generations;Geographic Locations;Geography;Goals;Human;IL8 gene;improved;individualized medicine;Inflammatory;Knowledge;Kynurenine;Laboratories;lateral flow assay;lipidomics;low and middle-income countries;Lung;Lung Diseases;Measurement;Measures;metabolomics;Modeling;molecular marker;Molecular Profiling;Monitor;mortality;multiple omics;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;Notification;Outcome;Patients;peripheral blood;Persons;Pilot Projects;Plasma;point of care;point of care testing;Population;practice setting;precision medicine;Prediction of Response to Therapy;predictive signature;primary care clinic;primary care setting;programs;prospective;Prospective cohort;Public Health;Pulmonary Tuberculosis;Relapse;relapse risk;Reporting;repository;Research;Research Project Grants;Research Support;Resolution;Resource-limited setting;Resources;Sampling;Severity of illness;small molecule;Specimen;Sputum;Succinates;Symptoms;Systems Biology;Testing;Time;transcriptomics;Translating;translational potential;transmission process;treatment duration;Treatment Failure;Treatment outcome;Treatment Protocols;treatment response;treatment risk;Triage;Tryptophan;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;tuberculosis treatment;United States National Institutes of Health;Universities;Urine;Validation;Work;X-Ray Computed Tomography

PROJECT_TITLE: Immunometabolic Biomarkers to Advance TB Diagnosis and Treatment Monitoring

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-F (02)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: Columbus

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative By kindergarten entry, children from low-socioeconomic status (SES) backgrounds lag behind their peers from higher SES homes in early literacy and other school readiness skills and these gaps persist through high school. The goal of this study is to determine whether an intervention to support caregivers in engaging with their children while co-using educational media can improve children's early literacy skills, compared to an aligned shared book reading intervention and to no intervention. Given that early literacy skills predict children's later academic learning, this home intervention, which aims to shape the communication patterns surrounding a common, family-friendly activity, has the potential to positively influence the trajectory of low- income children's academic success.

PI_NAMEs: DORE, REBECCA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 4 year old;Address;Adherence;Adopted;Adult;Adult Children;Area;Belief;Books;boys;Businesses;Caregiver support;Caregivers;Child;Child Development;Child Support;Communication;design;Development;Dose;Education;Educational process of instructing;Evidence based practice;experience;Exposure to;Face;Family;follow-up;Friends;Goals;Growth;high school;Home;Household;implementation fidelity;implementation framework;implementation science;improved;improved outcome;innovation;interest;Intervention;intervention effect;Joints;Justice;kindergarten;Learning;literacy;Long-Term Effects;Low income;low socioeconomic status;Maintenance;marginalization;Measures;Media Intervention;media use;Mediating;Methods;Modeling;National Institute of Child Health and Human Development;Outcome;Participant;Pattern;peer;Population;Poverty;pressure;Printing;Randomized, Controlled Trials;Readiness;Reading;reading difficulties;Research;Schools;Self Efficacy;sex;Shapes;skills;social;Socioeconomic Status;success;Technology;Testing;Theoretical Domains framework;Time;Visit;Work

PROJECT_TITLE: Efficacy and Mechanisms of Media and Storybook Interventions to Promote Children’s Early Literacy Skills via Caregiver Engagement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-H (02)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative Midbrain dopamine neurons densely innervate the striatum, and this projection is thought to be critical for reinforcement learning as well as motor control. This proposal will combine behavioral, computational, circuit perturbation techniques and optical neuromodulatory sensors to test the novel hypothesis that the neuromodulator acetylcholine dynamically gates whether dopamine drives learning or moving. All neuropsychiatric disorders, including schizophrenia and bipolar disorder are thought to reflect dysfunction of the dopamine system, and are characterized by aberrant reward processing and disordered decision-making.

PI_NAMEs: CONSTANTINOPLE, CHRISTINE M (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Acceleration;Acetylcholine;Affect;Amygdaloid structure;Animals;Area;Basal Ganglia;Behavior;Behavioral;Behavioral Model;Behavioral Paradigm;Bipolar Disorder;Brain;Cells;cholinergic;Corpus striatum structure;Data;Decision Making;Disease;Dissociation;Dopamine;Dopamine Receptor;dopamine system;dopaminergic neuron;Dorsal;Electrophysiology (science);Elements;Environment;Event;experimental study;Fiber;Functional disorder;Goals;Interneurons;kinematics;Learning;Lesion;Measures;Mental Depression;Midbrain structure;Motor;motor control;Movement;Movement Disorders;neural;neural correlate;Neuromodulator;Neuronal Plasticity;Neurons;neuropsychiatric disorder;neuroregulation;new therapeutic target;novel;Optical Methods;Optics;optogenetics;Outcome;Parkinson Disease;permissiveness;Photometry;Policies;postsynaptic;Prefrontal Cortex;presynaptic;Presynaptic Terminals;Probability;Psychological reinforcement;Rattus;Receptor Activation;Research;response;reward processing;Rewards;Role;Schizophrenia;sensor;Signal Transduction;Specific qualifier value;Structure;Synapses;System;Techniques;Testing;Thalamic structure;Training;Update;Work

PROJECT_TITLE: Acetylcholine determines dopamine's role in learning versus moving

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Light acts through the retina to regulate the circadian clock. Circadian dysregulation is implicated in cancer, cardiovascular disease, metabolic disorder, and mental illness. We propose to define the normal function of retinal neurons and their signaling to the principal circadian clock, which is located in the brain, to gain insight into the basis of circadian regulation and dysregulation.

PI_NAMEs: DO, MICHAEL TRI HOANG (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Acute;Address;Adopted;Animals;Behavior;Behavioral;Biological;Bioluminescence;biophysical techniques;Brain;Brain region;Cardiovascular Diseases;cell type;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Complex;Cues;Electrophysiology (science);Environment;experimental study;Eye;Fluorescence;Frequencies;Gene Expression;Generations;Genetic;Health;Hypothalamic structure;Image;in vivo;insight;Investigation;Knowledge;Light;light intensity;Lighting;Lightning;Link;Malignant Neoplasms;Mammals;melanopsin;Mental disorders;Metabolic Diseases;Methods;millisecond;nerve supply;neural;Neurons;neurotransmission;novel;Optic Nerve;Output;patch clamp;Pathway interactions;Pattern;pharmacologic;Pharmacology;Phase;Photons;Photosensitivity;Physiological;Physiology;Population;Positioning Attribute;Preparation;preservation;Presynaptic Terminals;Process;Property;Proxy;Regulation;Resolution;response;Retina;Retinal Ganglion Cells;retinal neuron;Signal Transduction;Slice;spatiotemporal;Stimulus;suprachiasmatic nucleus;Synapses;System;Tectum Mesencephali;Testing;the sun;Time;Variant;Vision;Visual Pathways;Visual System;Work

PROJECT_TITLE: Signal Generation and Processing in the Retinohypothalamic Pathway

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Genetics;Human Genome;Lung;Pulmonary Fibrosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE  Pulmonary fibrosis is linked to a failure of regeneration that involves epithelial-fibroblast interactions. This project will study the role of a metabolic enzyme, nicotinamide N-methyltransferase (NNMT), that reprograms cellular function and behavior of fibroblasts from a pro-regenerative to a pro-fibrotic phenotype.

PI_NAMEs: THANNICKAL, VICTOR J. (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: 3-Dimensional;Acceleration;Acetyl Coenzyme A;Acetylation;Address;Adenine;Adult;Alveolar;Animal Model;Apoptosis;Applications Grants;ATAC-seq;Bioenergetics;cell behavior;Cell Physiology;Cells;Cellular Metabolic Process;Chromatin;cofactor;Data;Development;Enzymes;Epigenetic Process;epigenetic profiling;Epithelium;epithelium regeneration;Failure;Fibroblasts;Fibrosis;histone methylation;histone modification;Human;idiopathic pulmonary fibrosis;Impairment;in vivo;injury and repair;Link;Lung;lung injury;Maintenance;Mammals;Mesenchymal;Mesenchyme;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methylation;Modeling;Molecular Conformation;Myofibroblast;Natural regeneration;Niacinamide;Nicotinamide adenine dinucleotide;Nicotinamide N-Methyltransferase;Organ;Organogenesis;Organoids;Pathologic;Pattern;pharmacologic;Phenotype;Phosphorylation;Physiological;profibrotic cytokine;programs;Protein Methylation;Pulmonary Fibrosis;pyridine;Reaction;regeneration potential;regenerative;Regenerative capacity;Regenerative response;Regulation;Rejuvenation;Resistance;Resolution;Respiratory System;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;single-cell RNA sequencing;Slice;stem cell niche;stem cell population;stem cells;Stromal Cells;Testing;Therapeutic;tissue injury;tissue regeneration;Tissues;Transforming Growth Factors;tripolyphosphate

PROJECT_TITLE: Metabolic Reprogramming of the Alveolar Stem Cell Niche in Pulmonary Fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Contraception/Reproduction;Digestive Diseases;Hepatitis;Liver Disease;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Pregnancy;Prevention;Women's Health Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Nonalcoholic fatty liver disease (NAFLD) is a leading cause for cirrhosis and liver transplantation in women, and there is an urgent need to identify nonalcoholic steatohepatitis (NASH), its progressive form, before complications have developed. Pregnancyis an opportunity to diagnose,risk-stratify, and intervene before disease progression.This project will prospectively evaluate the association of NAFLD diagnosed in pregnancy with adverse pregnancy outcomes, identify individuals with “at-risk” NASH in the post-pregnancy period, and investigate the NAFLD associated lipid-mediated mechanisms that predict these outcomes.

PI_NAMEs: KUSHNER, TATYANA  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Address;adverse pregnancy outcome;Affect;Age;aged;antenatal;attenuation;Biological;Body mass index;Breast Feeding;Cirrhosis;Clinical;Clinical Data;Counseling;Data;Development;Diagnosis;Diet;dietary;Discipline of obstetrics;disease diagnosis;Disease Progression;early pregnancy;elastography;Enrollment;Ethnic Origin;Event;Evolution;fatty acid oxidation;Fatty Acids;Fatty Liver;follow-up;Future;Gestational Diabetes;gestational weight gain;health care availability;Healthcare Systems;Hepatic;High Prevalence;high risk;High Risk Woman;Hispanic;Hispanic Populations;improved;Incidence;Individual;insight;Intervention;Knowledge;lipid metabolism;lipidomics;Lipids;Liver;Liver diseases;liver transplantation;Longitudinal Studies;maternal morbidity;Maternal Mortality;Mediating;Metabolic;Methods;mortality;multidisciplinary;Natural History;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Outcome;outcome prediction;Participant;Pathogenesis;Pathway interactions;patient population;Pilot Projects;Play;Polyunsaturated Fatty Acids;Population;post pregnancy;Postpartum Period;Pre-Eclampsia;Predisposing Factor;Pregnancy;pregnancy hypertension;Pregnancy Outcome;pregnant;Pregnant Women;Prenatal care;prepregnancy;Prevalence;prevent;prospective;Prospective Studies;Protocols documentation;Questionnaires;Radiology Specialty;Recommendation;Reporting;reproductive;Reproductive Periods;Research;Risk;Risk Factors;risk stratification;Role;routine screening;Sample Size;Serum;sociodemographics;Specimen;Staging;Subgroup;Supplementation;Testing;Therapeutic;Time;tool;ultrasound;Weight;Woman;Women's Health

PROJECT_TITLE: Targeting Nonalcoholic Fatty Liver Disease during the reproductive period to improve women's health outcomes


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Clinical Research;Neurosciences

ORG_CITY: HARRISONBURG

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: JAMES MADISON UNIVERSITY

PHR: Narrative Older adults have poorer vestibular, or balance, function and the reasons for this are not well understood. This research will examine the natural disease state of age-related changes in the human vestibular system, with an emphases on a novel, sustained stimulation approach to study nonlinear aspects of vestibular reflexes. Information learned from this research will help to better understand basic aspects of human vestibular function as well as underlying causes of balance difficulties in older adults and may help to develop new clinical tools for the diagnosis and monitoring of vestibular disease.

PI_NAMEs: PIKER, ERIN G (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acceleration;Accidents;Action Potentials;Address;Adult;Affect;age effect;age related;age related changes;age related decline;aged;Aging;aging process;Animal Model;Basic Science;Biological Process;Cervical;Cessation of life;Classification;Clinical;clinical diagnosis;clinical phenotype;Data;Development;Diagnosis;Diagnostic;Discontinuous Capillary;Disease;Dizziness;Early Diagnosis;Electrophysiology (science);equilibration disorder;Equilibrium;experimental study;fall risk;falls;Frequencies;Goals;harmonic distortion;Head Movements;Heterogeneity;Human;human model;improved;individualized medicine;Intervention;Knowledge;Learning;life span;Link;Measurement;Measures;Methods;middle age;Modeling;Monitor;Motor;Muscle;Muscle function;Muscular Atrophy;Noise;novel;older adult;Organ;otoconia;Pathway interactions;Patients;Performance;Peripheral;Phenotype;Physiological;Physiology;Population;predictive modeling;programs;Property;Reflex action;Rehabilitation therapy;Research;response;Risk Factors;Saccule and Utricle;Saccule structure;Sensory;Signal Transduction;skeletal;Stimulus;Structure;System;Testing;Time;tool;Treatment Efficacy;Utricle structure;Vertigo;Vestibular Diseases;Vestibular dysfunction;Vestibular function;Vestibular loss;vestibular reflex;vestibular system;Work;young adult

PROJECT_TITLE: Nonlinearities in Human Vestibular Reflexes


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: NARRATIVE This project is interested in developing automatic question answering (QA) data and methods for improving the usability of electronic health record (EHR) systems. Specifically we focus on trying to balance the trustworthiness of our existing EHR QA system with the high-performance of state- of-the-art QA based on large language models (LLMs).

PI_NAMEs: ROBERTS, KIRK EDWARD (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Classification;Clinical;clinical practice;Data;design;Diagnosis;Electronic Health Record;electronic health record system;Environment;Equilibrium;evidence base;Hallucinations;Hybrids;Improve Access;improved;interest;Interview;Intuition;Language;large language model;Learning;Medical;Methods;Modeling;natural language;Natural Language Processing;novel strategies;Patients;Performance;Psychological reinforcement;satisfaction;Structure;structured data;System;Text;Training;trustworthiness;unstructured data;uptake;usability;Work;yeast two hybrid system

PROJECT_TITLE: Trustworthy and High-Performance Question Answering for Electronic Health Records

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative Children who grow up in low-income homes are at higher risk for poor health and early mortality for their entire lives. It is difficult to study the effects of childhood social conditions on adult health, however, because sometimes these negative impacts are not evident for years or even decades. In this project, we test whether DNA-methylation (a type of epigenetic modification of the human genome) can help researchers see how children’s health is being negatively affected by adverse social conditions, using a unique research design that analyzes epigenetic data previously collected from four cohorts that span early childhood to older adulthood.

PI_NAMEs: HARDEN, KATHRYN PAIGE (contact);RAFFINGTON, LAUREL

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Adolescence;Adult;Affect;Age;aging related disease;Alzheimer's Disease;arm;Biological;Biological Aging;Biological Markers;biomarker identification;candidate identification;Child;Child Development;Child Health;Child Welfare;Childhood;Cognitive;cognitive function;cohort;Communities;Computer software;Data;Data Set;Development;Disease;DNA Methylation;early childhood;Economic Conditions;Environment;Epigenetic Process;Experimental Designs;Family;Funding;Future;genomic biomarker;Genomics;Gifts;Health;Health and Retirement Study;high risk;Home;Human Genome;human old age (65+);indexing;Informatics;insight;Intervention;Knowledge;late life;Life;Life Cycle Stages;life span;Link;longitudinal design;Low income;Measures;Methylation;methylation testing;methylome;Modification;Molecular;Morbidity - disease rate;mortality;Mothers;novel;older adult;Pathway interactions;Patient Recruitments;Personal Satisfaction;physical conditioning;Poverty;Preventive;Process;Proxy;Publishing;randomized trial;Randomized, Controlled Trials;Reporting;Research;Research Design;Research Personnel;Research Support;Risk;saliva sample;Sampling;Social Conditions;Social Environment;Social stratification;socioeconomic disparity;Socioeconomic Status;socioeconomics;Specimen;success;Testing;Texas;Time;tool;Travel;Twin Multiple Birth;Yawning

PROJECT_TITLE: Epigenetic Pathways of Socioeconomic Disparities in Physical and Cognitive Health Across the Lifespan

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Immunotherapy

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: In this application we propose to define how a molecular motif, responsible for B cell activation, possesses an intrinsic regulatory function that can prevent or modulate B cell activation. The overarching goal of these studies is to better understand how the earliest events in lymphocyte activation impact the balance of activating and inhibitory signaling, which shape B cell responses and immune tolerance. Gained knowledge has direct translational implications for the design of chimeric antigen receptor for immunotherapies that exploit this molecular motif.

PI_NAMEs: GETAHUN, ANDREW  (contact)

PROGRAM_OFFICER_NAME: BREEN, JOSEPH J

PROJECT_TERMS: Antibody Response;Antigen Receptors;Autoimmunity;autoreactive B cell;B lymphoid malignancy;B-Cell Activation;B-Cell Development;B-Lymphocytes;Binding;Biochemical;Biological;Biological Process;Biology;Cell Line;chimeric antigen receptor;crosslink;Data;design;Development;Distal;Docking;Equilibrium;Event;genetic regulatory protein;Goals;Immune Tolerance;Immunity;Immunotherapy;improved;Individual;inorganic phosphate;Inositol;insight;ITAM;ITIM;Knowledge;Lymphocyte Activation;Maintenance;Mediating;Membrane;Modeling;Molecular;mouse model;novel;Pathologic;Phenotype;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Phosphorylation;PIK3CG gene;Play;prevent;Protein Tyrosine Phosphatase;PTPN6 gene;receptor;receptor binding;recruit;Regulation;response;Role;Shapes;Signal Transduction;Site;src-Family Kinases;synthetic biology;Testing;Tyrosine;Tyrosine Phosphorylation

PROJECT_TITLE: CD79A as a molecular switch regulating B cell activation

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Dissemination and Implementation Research;Prevention;Women's Health Research

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Supporting deimplementation of low-value, preference-sensitive breast cancer surgical care is a public health priority because these operations have limited clinical benefit while having a substantial negative impact on psychosocial, physical and financial outcomes. A critical gap towards supporting deimplementation of low-value preference-sensitive care is our understanding of what happens within patient-surgeon interactions. This project aims to address this gap by analyzing existing audio-recorded breast cancer surgical consultations to understand the relationship between what surgeons and patients say during the consult, and how decisions are made for two low-value, preference-sensitive operations (sentinel lymph node biopsy for women ≥70 years of age and contralateral prophylactic mastectomy).

PI_NAMEs: NEUMAN, HEATHER B (contact)

PROGRAM_OFFICER_NAME: SARMA, ELIZABETH ANNE

PROJECT_TERMS: Address;Age Years;Attitude;Automobile Driving;Axillary Lymph Node Dissection;Belief;Breast;Breast Cancer Patient;breast surgery;cancer care;cancer risk;cancer surgery;care delivery;Caring;Categories;Clinical;Clinical Trials;Code;community center;Community Clinical Oncology Program;Consult;Consultations;Contralateral;Data Set;Decision Making;decision-making capacity;Deimplementation;design;Development;Dimensions;Emotions;Excision;Funding;Future;Genetic Transcription;Goals;Grant;improved;insight;Intervention;Interview;Knowledge;Lead;Literature;Malignant Breast Neoplasm;Measures;Modeling;novel;Oncology;operation;Operative Surgical Procedures;Outcome;Patient Care;patient oriented;Patient Preferences;Patients;Pattern;Performance;preference;Procedures;Process;Productivity;prognostic value;programs;prophylactic mastectomy;psychosocial;public health priorities;Race;Recommendation;Research;Risk;Sampling;Sentinel Lymph Node Biopsy;shared decision making;Societies;socioeconomics;statistics;Surgeon;Taxonomy;Testing;Time;tool;treatment planning;United States;United States Agency for Healthcare Research and Quality;Unnecessary Procedures;Woman

PROJECT_TITLE: Understanding patient-surgeon interactions to support deimplementation of preference-sensitive low value care

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: NARRATIVE Glioblastoma (GBM) is a deadly and incurable brain tumor, characterized by high inter-patient heterogeneity and intra-tumoral plasticity, which pose significant challenges in developing effective therapies. Here, we aim to uncover and target central regulatory nodes that govern the GBM programs by focusing on essential non-coding DNA elements, known as enhancers. By building networks of enhancer-gene communication in the context of three-dimesional nucleus, we aim to (i) identify common central nodes across patients and cellular states, (ii) dissect their significance in GBM programs and tumorigenic properties and (iii) expose unique vulnerabilities for future targeted therapies.

PI_NAMEs: APOSTOLOU, EFFIE  (contact);FINE, HOWARD A.;KHURANA, EKTA

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: 3-Dimensional;Address;Adult;Architecture;Behavior;Binding;Biological Assay;Biology;Brain Neoplasms;cancer genomics;Cell Nucleus;cell type;Cells;Chromatin;Clinical;cofactor;Coin;Communication;Complex;Computational Biology;Computer Analysis;Computer Models;Data;Data Set;DNA;Drug resistance;effective therapy;Elements;Endowment;Engineering;Enhancers;Epigenetic Process;epigenetic silencing;Exhibits;experimental study;fitness;Future;Gene Expression;gene network;Genes;Genetic;Genetic Transcription;genetic variant;Genetic Variation;Genome;Genomics;Glioblastoma;Glioma;Heterogeneity;in vivo;insight;Knowledge;Link;Logic;Malignant Neoplasms;Molecular;molecular subtypes;Multiomic Data;Mutation;Neighborhoods;nerve stem cell;Network-based;novel therapeutic intervention;Nuclear;Oncogenic;Outcome;Pathway Analysis;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Primary Brain Neoplasms;Process;programs;Proliferating;promoter;Property;Proteins;Proteomics;Recurrence;Regulation;Resistance;Resolution;Sampling;single-cell RNA sequencing;Specificity;stem cells;stem-like cell;Stress;Structure;targeted treatment;Technology;Therapeutic;therapeutic target;therapy resistant;tool;transcription factor;transcriptomics;tumor;tumor heterogeneity;tumorigenic;Untranslated RNA;Variant;Work

PROJECT_TITLE: Identifying and Targeting 3D Regulatory Nodes that Maintain Glioblastoma Programs.

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Lupus;Prevention;Scleroderma;Vaccine Related

ORG_CITY: STANFORD

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The proposed study will elucidate COVID-19 vaccine responses in patients with systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). Our highly multidisciplinary team will use state-of-the-art technologies and systems biology to analyze longitudinally-collected samples from patients in Stanford’s lupus and scleroderma clinics. Our work could lead to better understanding of vaccine efficacy and vaccine adverse events, and to elucidating molecular underpinnings of autoimmune diseases (AID) more broadly.

PI_NAMEs: UTZ, PAUL JOSEPH (contact);ZABA, LISA

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: adaptive immune response;Address;adverse event risk;Antibodies;Antibody Repertoire;Antigens;Autoantibodies;Autoimmune Diseases;autoreactive B cell;autoreactivity;B cell repertoire;B-Cell Antigen Receptor;B-Lymphocytes;Biological Assay;Blood;booster vaccine;CD8B1 gene;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinic;clinically actionable;cohort;Connective Tissue Diseases;COVID-19;COVID-19 prevention;COVID-19 vaccination;COVID-19 vaccine;Custom;CXC chemokine I-TAC;CXCL10 gene;CXCL9 gene;cytokine;Data;Data Set;Development;Disease;DNA Vaccines;Effectiveness;Enrollment;Ensure;epigenetic profiling;evidence base;Flare;Frequencies;Future;future pandemic;Genetic Transcription;Goals;high risk;HIV;IgG autoantibodies;Immune;Immune response;Immunity;Immunocompromised Host;immunogenicity;Immunoglobulin G;improved;In Vitro;Individual;influenza virus vaccine;Informatics;Innate Immune System;insight;Interferon Type II;Interferons;Knowledge;longitudinal analysis;Lung;Lupus;Measurement;Measures;Mediating;Memory;Messenger RNA;Methods;MHC Class I Genes;Minor;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Musculoskeletal Diseases;Natural Immunity;next generation;pandemic preparedness;Participant;Pathology;patient subsets;Patients;Persons;Pfizer-BioNTech COVID-19 vaccine;Pharmaceutical Preparations;Phenotype;Plasma;Population;Prevention;Productivity;Proteins;Publishing;Recombinants;Regimen;Research;responders and non-responders;response;RNA vaccine;Role;Sampling;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Scleroderma;Series;Skin;skin disorder;System;Systemic Lupus Erythematosus;Systemic Scleroderma;Systems Biology;T-Cell Receptor;T-Lymphocyte;Technology;Testing;Time;Transcript;transcriptome sequencing;Translating;Vaccination;vaccine adverse event;vaccine efficacy;vaccine hesitancy;vaccine immunogenicity;vaccine platform;vaccine response;vaccine safety;vaccine trial;Vaccines;vaccinology;variants of concern;Viral;Viral Antibodies;Virus;Work

PROJECT_TITLE: Mechanisms of BNT162b2 Vaccine Immunogenicity in Systemic Lupus Erythematosus or Scleroderma

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]