NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Cervical Cancer;Clinical Research;HIV/AIDS;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: Project Narrative: In a collaboration between the University of Cape Town and Columbia University, we will investigate the clinical utility of an automated visual method of assessing the cervix for the purposes of screening for cervical cancer in HIV-positive women in South Africa. We will investigate whether this method can discriminate between true cervical precancerous lesions in need of treatment from those that do not require treatment among women who are positive for human papilloma virus (HPV) DNA and who have undergone treatment as part of prior rounds of screening.

PI_NAMEs: KUHN, LOUISE ;MBATANI, NOMONDE HAZEL;SAIDU, RAKIYA SAIDU (contact)

PROGRAM_OFFICER_NAME: DOMINGUEZ, GERALDINA

PROJECT_TERMS: ablative procedure;Address;antiretroviral therapy;automated visual evaluation;Biological Assay;Biopsy;cancer therapy;Cellular Phone;Cervical;Cervical Cancer Screening;Cervical Intraepithelial Neoplasia;Cervix Uteri;Characteristics;Clinical;Clinical Research;Collaborations;Colposcopy;Country;Cytology;Decision Making;Development;Diagnosis;Diagnostic;digital;digital imaging;Disadvantaged;Discipline of obstetrics;DNA;Electrocoagulation;Generations;Guidelines;Gynecology;Health Services;high risk population;High Risk Woman;Histologic;histological specimens;HIV;HIV Seronegativity;HIV Seropositivity;HPV positive;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papillomavirus;Income;Infrastructure;Institution;Lead;Lesion;Licensing;Malignant neoplasm of cervix uteri;Methods;Minor;Modeling;Modification;Morbidity - disease rate;mortality;new technology;overtreatment;Pap smear;Performance;point of care;premalignant;Primary Prevention;Procedures;Province;Recommendation;recruit;Recurrence;Resource-limited setting;Resources;Sampling;screening;screening guidelines;screening program;screening services;Secondary Prevention;Services;South Africa;success;System;Technology;Testing;Training;Treatment Failure;Triage;Universities;Vagina;Viral Load result;Visual;Woman;Women's Group;women's treatment;Work;World Health Organization

PROJECT_TITLE: Automated Visual Evaluation for Cervical Cancer Screening in HIV-positive Women


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Lung

ORG_CITY: Newark

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Summary  This project aims at understanding the function and regulation of mucosal associated invariant T cells in allergic airway inflammation. Our work will provide novel insights into the biology of innate-like T cells, and may also inform strategies to combat asthma.

PI_NAMEs: YANG, QI  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: 1 year old;7 year old;Adoptive Transfer;Adult;airway hyperresponsiveness;airway immune response;airway inflammation;Allergens;allergic airway inflammation;Alternaria;Anabolism;Anti-Inflammatory Agents;Asthma;asthmatic patient;Biology;Biopsy;Biopsy Specimen;Brain Death;Bronchi;CD4 Positive T Lymphocytes;Cell Count;Cells;cellular engineering;Child;combat;Data;Development;Engineered Probiotics;Escherichia coli;Exhibits;Frequencies;Genes;House Dust Mite Allergens;Human;Immune;Impairment;Individual;Inflammatory;Inflammatory Response;insight;Lung;Lung Diseases;Lymphoid Cell;Mediating;Metabolic;microbial;Molecular;mouse model;Mucous Membrane;Mus;novel;novel strategies;Organ Donor;Pathogenicity;Pathway interactions;peripheral blood;Probiotics;Production;Proliferating;Property;Public Health;Publishing;Regulation;Repression;respiratory examination;response;Riboflavin;Risk;Role;Sampling;single-cell RNA sequencing;Sputum;Structure of parenchyma of lung;T-Lymphocyte;Testing;Therapeutic;Work

PROJECT_TITLE: Function and regulation of mucosal associated invariant T cells in the lung

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Genetics;Infectious Diseases;Microbiome;Nutrition;Precision Medicine

ORG_CITY: STANFORD

ORG_DEPT: PHYSICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: The human gut is home to a diverse microbial community that plays a critical role in maintaining our health and reducing susceptibility to disease. This project aims to quantify the ongoing evolutionary processes that shape the genetic composition of this community within the lifetime of a single host. A quantitative understanding of this process will help us predict how gut microbiota will respond and recover from perturbations such as drugs or diet, and will be crucial for the development of personalized microbiome-based therapies.

PI_NAMEs: GOOD, BENJAMIN H (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Address;Antibiotic Resistance;Automobile Driving;Biophysics;Cells;Communities;Complex;computerized tools;Data;Development;Diet;Disease;Ecosystem;Evolution;fecal transplantation;fitness;Future;Genetic;Genetic Models;genetic variant;Germ-Free;Goals;gut bacteria;gut metagenome;gut microbiota;Health;Home;Human;In Situ;in vivo;insight;Libraries;Link;Maps;Measures;Methods;microbial community;microbiome therapeutics;microbiota;Modeling;Mus;Mutation;Natural Selections;Oceans;personalized medicine;Pharmaceutical Preparations;Play;Population;Population Genetics;predictive modeling;Predisposition;Process;resistance mutation;response;Role;Sampling;Series;Shapes;Soil;success;Taxonomy;Therapeutic;Time;Work

PROJECT_TITLE: Quantitative approaches for mapping the real-time evolution of the gut microbiota

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Lupus;Networking and Information Technology R&D (NITRD)

ORG_CITY: ANN ARBOR

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE The Immunogenomics and Systems Biology Core (ISBC) at University of Michigan will provide the technical and analytic support for the entire AMP AIM network. The ISBC will expand cutting-edge analytical technologies, that we have developed, to conduct systems-level analyzes of the broad range of multi-omics data generated in the AMP AIM, and link with genetic information, to facilitate identification of molecular disease determinants at the cellular level, determine their roles in shaping inflammatory signaling, disease heterogeneity, and treatment response.

PI_NAMEs: GUDJONSSON, JOHANN ELI (contact);TSOI, LAM CHEUNG;WELCH, JOSHUA ;ZHOU, XIANG

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Acceleration;Address;advanced analytics;Antigen-Antibody Complex;ATAC-seq;Atopic Dermatitis;Autoimmune Diseases;Autoimmune Process;Basic Science;Binding;Biological Assay;Biological Markers;Biological Process;Biology;biomarker identification;CD8B1 gene;cell type;Cells;Chromosome Mapping;Clinical Data;Clinical Investigator;Computer Models;Computer software;computerized data processing;Computing Methodologies;Consultations;cytokine;Data;Data Analyses;data analysis pipeline;Data Analytics;data curation;data integration;data management;data modalities;Data Set;data standards;Development;Disease;disease heterogeneity;E-learning;Epigenetic Process;epigenomics;experience;Fibroblasts;flexibility;Functional disorder;Funding;Generations;Genetic;genetic approach;genetic information;Genetic Variation;Genomic approach;genomic data;Genomics;Goals;Heterogeneity;high throughput screening;Immune;Immune System Diseases;Immunogenomics;Inflammatory;innovation;insight;Intervention;keratinocyte;Link;Lupus;Maps;Mediating;Michigan;Modality;Modeling;Molecular;Molecular Disease;Molecular Profiling;Multiomic Data;multiple data types;multiple omics;novel;open source tool;Pathogenesis;Pathogenicity;Performance;Population;Process;programs;Psoriasis;Psoriatic Arthritis;Research;Research Personnel;Resources;response;Role;sample collection;Scleroderma;Shapes;Signal Transduction;single cell genomics;Skin;Standardization;Statistical Models;structured data;System;Systemic Lupus Erythematosus;Systems Biology;Technology;Therapeutic Intervention;Training;transcription factor;transcriptome sequencing;transcriptomics;translational scientist;Translations;treatment response;Universities

PROJECT_TITLE: Immunogenomics and Systems Biology Core


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Lung;Neurodegenerative;Pulmonary Hypertension;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative In this proposal, we aim to establish the role of a specific protein called frataxin that we believe promotes the development of a deadly yet mysterious disease of the blood vessels in the lung, pulmonary hypertension (PH). Interestingly, naturally occurring mutations in frataxin cause a syndrome called Friedreich’s ataxia, where associated heart disease is linked with PH; thus, we plan to determine how those mutations directly promote lung blood vessel dysfunction in these patients. If successful, our work could shape genetic and molecular principles of how multiple types of PH develop and drive development of new medications for PH controlling frataxin activity.

PI_NAMEs: CHAN, STEPHEN Y (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: adenovirus mediated delivery;analog;Ataxia;Automobile Driving;Binding;Biogenesis;Blood Vessels;Cardiomyopathies;Cell Aging;Cell Cycle Arrest;Cell Line;Cell Proliferation;cell type;Cells;Cellular biology;Classification;cohort;Confusion;cytokine;Data;Dependovirus;Development;Disease;DNA Damage;Dose;Drug Controls;drug efficacy;Endothelial Cells;endothelial stem cell;Endothelium;Evolution;frataxin;Friedreich Ataxia;Functional disorder;Funding;Genetic;Genetically Engineered Mouse;genome editing;Genomics;Genotoxic Stress;GSTP1 gene;Heart Atrium;Heart Diseases;Hematological Disease;Heterogeneity;Histology;Human;hypertension control;Hypertrophic Cardiomyopathy;Hypoxia;improved;in vivo;induced pluripotent stem cell;Inflammation;Inflammatory;inhibitor;Interleukin-6;iron deficiency;Knock-out;Knockout Mice;Left;Link;Lung;Metabolic dysfunction;Mitochondria;mitochondrial metabolism;Modeling;Molecular;mouse model;Mutation;Myelogenous;Myeloid Cells;novel;novel therapeutics;Nuclear;Patients;Pharmaceutical Preparations;Phenotype;Plasma;prevent;Proteins;pulmonary arterial pressure;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular disorder;pulmonary vascular remodeling;Regulation;replication stress;Reporting;Repression;Rodent;Role;senescence;senescence associated secretory phenotype;senolytics;Shapes;Shunt Device;Signal Transduction;single-cell RNA sequencing;Specimen;Stress;Sulfur;Sulofenur;Syndrome;Technology;Telephone;therapeutic development;Transgenic Organisms;Vascular Endothelial Cell;Work

PROJECT_TITLE: Frataxin deficiency as a cause of endothelial senescence in multiple subtypes of pulmonary hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-G(03)]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: We propose to upgrade our 11.7T MRI scanner to state-of-the-art hardware and software that will benefit a large group of researchers at Johns Hopkins University School of Medicine and Kennedy Krieger Institute. The scanner provides a core magnetic resonance facility within an interdisciplinary environment for the investigation of disease models, either their mechanisms, possible treatments, or the development of methods to diagnose them. These include conditions such as cancer, Alzheimer’s Disease, Huntington’s Disease, Parkinson’s Disease, glycogen storage disease, hypoxic ischemic injury, peripheral artery disease, kidney disease, traumatic brain injury, hydrocephalus, and others.

PI_NAMEs: VAN ZIJL, PETER CM (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: 14 year old;Acceleration;Animal Model;Animals;Chemicals;Compensation;Computer software;computerized data processing;Computers;data acquisition;Diffusion;disability;Disease;Equipment;experimental study;Frequencies;Functional Magnetic Resonance Imaging;Funding;Generations;Grant;Image;imaging approach;improved;magnetic field;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Monitor;Motion;Performance;Physiologic pulse;Physiological;Research;Research Institute;Research Personnel;Scanning;Signal Transduction;Slice;spectroscopic imaging;Speed;System;Time;United States National Institutes of Health;Universities;Update

PROJECT_TITLE: Upgrade of the 11.7T Research Scanner at the F.M. Kirby Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (31)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: BRONX

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative  African American men have an increased risk for both prostate cancer incidence and mortality. Although socio-economic status and other environmental and cultural factors likely contribute to this racial disparity, emerging evidence has shown an important role of genetic and epigenetic factors in the pathogenesis of African American prostate cancer. In this study, we propose a series of experiments to directly test our central hypothesis that aberrant androgen signaling activation in both prostatic epithelia and stroma promotes prostate cancer initiation, progression, and hormone refractoriness in African American patients through dysregulation of insulin-like growth factor-1 and Wnt signaling pathways, which should directly impact the current paradigms and lead to the development of new therapeutic strategies to improve clinical outcomes for African American prostate cancer patients.

PI_NAMEs: SUN, ZIJIE  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Address;Adenine;advanced disease;advanced prostate cancer;African American;Age;Age of Onset;Androgen Receptor;Androgens;Animal Model;AR gene;beta catenin;C-terminal;cancer initiation;cancer invasiveness;Cancer Patient;caucasian American;Cells;Cessation of life;Characteristics;Clinical;Code;Cytosine;Data;design;Development;Diagnosis;DNA Binding Domain;early onset;Epigenetic Process;Epithelial Cells;Exons;experimental study;Generations;Genetic;Genetically Engineered Mouse;Growth;Guanine;Hormones;Human;Hyperplasia;IGF1 gene;improved;Incidence;insight;Insulin-Like Growth Factor I;Length;Ligand Binding Domain;Ligands;Link;Literature;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;men;Molecular;mortality;Mus;N-terminal;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Oncogenic;Onset of illness;Outcome;Pathogenesis;Pathway interactions;Patients;Phenotype;Play;polyglutamine;Preventive;Property;Prostate;prostate cancer cell;prostate carcinogenesis;Prostatic;Prostatic Epithelium;Prostatic Stroma;Proteins;racial disparity;Receptor Activation;receptor expression;Receptor Signaling;receptor-mediated signaling;Refractory;Risk;Role;Sampling;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Socioeconomic Status;Stanolone;Stromal Cells;Testing;Testosterone;Therapeutic;Transactivation;transcription factor;Transgenic Mice;Trinucleotide Repeats;tumor;tumor progression;tumorigenesis;United States;WNT Signaling Pathway

PROJECT_TITLE: Aberrant Activation of Androgen Signaling Pathways in African American Prostate Cancer

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE This project will develop a bench-to-industry-to-bedside pipeline for training biomedical engineering students to bridge the gap between biotechnology research and clinical settings. By incorporating team-based learning experiences and addressing workforce skill gaps, this project aims to enhance biotechnology design education and meet the increasing demand for molecular and cellular therapies. Our vision cultivates essential bioengineering skills and prepare students for a future in molecular and cellular medicine combined with ethical frameworks in design that address equitable access to these emergent biotechnologies.

PI_NAMEs: KIM, CAMERON MICHAEL (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Address;biological systems;Biomanufacturing;biomaterial compatibility;Biomedical Engineering;Biomedical Research;Biotechnology;CAR T cell therapy;career;Cell Therapy;Cells;cellular engineering;chimeric antigen receptor T cells;Clinical;clinical application;Clinical Investigator;Collaborations;Communication;Communities;cost;design;Development;DNA;Education;Educational Curriculum;Educational process of instructing;Elements;Emerging Technologies;engineering design;Ensure;enzyme replacement therapy;Equitable healthcare;Equity;Escherichia coli;Ethics;experience;Feedback;Fostering;Funding;Future;gene therapy;Genes;Genetic Engineering;graduate student;health care availability;Healthcare;Human;human capital;human centered design;improved;Industry;Infrastructure;innovation;innovative technologies;Knowledge;laboratory experiment;Learning;Mammalian Cell;manufacture;Measures;Medical;Medicine;Mentorship;Molecular;Needs Assessment;novel;Outcome;Output;Physicians;Play;Population Heterogeneity;Post-Translational Protein Processing;Process;product development;Production;programs;protein expression;Proteome;Recombinant adeno-associated virus (rAAV);Recombinant Proteins;Research;research and development;Role;Scientist;Shapes;Side;skill acquisition;skills;Societies;student participation;student training;Students;success;synthetic biology;Therapeutic;therapeutic development;Thinking;Training;Translating;translational medicine;Translations;undergraduate student;United States;Vision;Work;Workforce Development

PROJECT_TITLE: From Biotech to Benchside: Team-Based Undergraduate Experiences in Design Thinking and Learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-G (J1)]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative More than 20,000 people in the United States are diagnosed with myeloproliferative neoplasms every year. Currently, we lack the tools to identify which patients will progress to acute leukemias and the only existing cure is allogeneic bone marrow transplant, a risky procedure that is feasible in only a small subset of the patients. Here, we propose a comprehensive research program to characterize individual cancer cells and reconstruct the history of disease progression in each patient, ultimately, identifying patient-specific targeted therapies that eradicate the cancer cells or hinder their growth.

PI_NAMEs: HORMOZ, SAHAND  (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Acute leukemia;Allogeneic Bone Marrow Transplantation;Animal Model;Atlases;Blood;Blood Cells;Bone Marrow;Bone marrow biopsy;cancer cell;cancer stem cell;Cell Communication;Cell Death;Cell division;Cells;Cessation of life;Cicatrix;CRISPR/Cas technology;Data;Development;Diagnosis;Disease;Disease Outcome;disease phenotype;Disease Progression;Dissociation;DNA;Engineering;Erythrocytes;Event;Gene Expression Profile;Genealogy;Genetic Transcription;Genome;genome sequencing;Genotype;Growth;Hematologic Neoplasms;Hematopoietic;Hematopoietic Neoplasms;hematopoietic stem cell expansion;Hematopoietic stem cells;Heritability;Heterogeneity;Human;In Situ;In Vitro;Individual;individual patient;JAK2 gene;Malignant Neoplasms;Measurement;Measures;Microscopy;Molecular;Mothers;mouse model;Mus;Mutate;Mutation;Myeloproliferative disease;Nature;Nucleotides;overpopulation;patient subsets;Patients;Pattern;Persons;Phenotype;Platelet Count measurement;Point Mutation;Population;Procedures;Process;programs;Proliferating;Recording of previous events;Research;Resolution;Role;Series;Somatic Mutation;stem cells;Symptoms;targeted treatment;technology platform;Testing;therapeutic evaluation;Therapeutic Studies;Time;Tissues;tool;transcriptome;transcriptomics;treatment strategy;Trees;tumor progression;United States;whole genome

PROJECT_TITLE: Tracing the lineage histories and differentiation trajectories of individual cancer cells in myeloproliferative neoplasms

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Cystic Fibrosis;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: The importance of a mechanistic understanding of the underlying complex interactions of microbes, mucins, metabolites, and transport phenomena cannot be overstated; infections of human mucosal layers are a critical global health problem with a greater burden of disease than cancer, heart disease, malaria, and HIV [7]. Our team of experts in computational modeling, microbial physiology, and mucus biology is well poised to tackle this complex problem. We will establish a framework for computational modeling of metabolism and transport in mucosal environments, resulting in the potential for more effective antibiotic targeting and ultimately strategies to treat diseases in which a disrupted mucosal interface is an important factor.

PI_NAMEs: FORD, ROSEANNE ;PAPIN, JASON  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acute;Algorithm Design;Antibiotics;Bacteria;Biochemical Pathway;Biology;burden of illness;Cataloging;clinically relevant;Complex;computer framework;Computer Models;Cystic Fibrosis;data integration;Disease;Environment;Etiology;Experimental Designs;Gene Expression Regulation;global health;Glycoproteins;Heart Diseases;HIV;Human;Infection;Infectious Agent;Lower Respiratory Tract Infection;Lung;Malaria;Malignant Neoplasms;Metabolic;metabolic phenotype;metabolic profile;Metabolism;Microbe;microbial;Microbial Biofilms;Microbial Physiology;microorganism;Modeling;Mucins;Mucous body substance;Mucous Membrane;mucus clearance;multi-scale modeling;network models;pathogen;Phenotype;Predictive Value;Property;Pseudomonas;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Role;small molecule;Work

PROJECT_TITLE: Multi-scale model of microbial phenotype modulation by mucins

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Lung

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Chronic Obstructive Pulmonary Disease (COPD) burdens over 16 million US adults and frequently results in recurrent emergency department visits and hospitalizations due to poor care transition support after initial COPD exacerbations. Our study will use innovative and rigorous implementation science methods to identify real-world solutions to decreasing COPD acute care revisits by concurrently studying care transition program intervention delivery methods (virtual versus in-person) and mentored implementation approaches (virtual or in-person). Lessons learned from this study could transform the way in which care is delivered to millions of COPD patients across the US and could even be applied widely to improve the effectiveness and sustainability of other multi-level, hospital-based programs.

PI_NAMEs: PRESS, VALERIE G (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Accident and Emergency department;acute care;Address;Adoption;Adult;Affect;American;burden of illness;Caring;Chest;Chicago;Chronic Obstructive Pulmonary Disease;Clinical;cohort;Cohort Studies;Collaborations;Communication;comparative effectiveness;compare effectiveness;Consolidated Framework for Implementation Research;Continuity of Patient Care;Data;Education;Educational workshop;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness/implementation design;effectiveness/implementation study;Emergency department visit;Engineering;Enrollment;Evaluation;evidence base;Evidence based intervention;Evidence based program;experience;Failure;Friends;Glean;Goals;Health system;Healthcare;hospital readmission;Hospital Societies;Hospitalization;Hospitals;Hybrids;implementation context;implementation outcomes;implementation questions;implementation science;implementation strategy;improved;Incentives;Individual;innovation;Intervention;intervention delivery;intervention program;Lead;Leadership;Long-Term Care;Mediator;Medicare;Medicine;Mentors;Methods;Modeling;mortality;National Heart, Lung, and Blood Institute;Outcome;Participant;Patient Care;Patients;Penetration;Persons;Pharmaceutical Preparations;Policies;post implementation;program costs;Program Effectiveness;Program Sustainability;programs;Public Health;Publishing;pulmonary function decline;Randomized;Recurrence;Reporting;Resources;respiratory;Savings;Self Management;self-management program;Site;Site Visit;Societies;Training;Universities;Variant;virtual;virtual intervention;virtual visit;Visit

PROJECT_TITLE: The Virtual Mentored Implementation to Reduce REVISITS (Reducing Respiratory Emergent Visits using Implementation Science Interventions Tailored to Setting) Study

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: ES

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Depression;Mental Health;Neurosciences;Nutrition;Pain Research;Prevention;Social Determinants of Health

ORG_CITY: DAVIS

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: We are investigating how universal regulatory mechanisms control response to environmental chemicals, nutrition and disease. Specifically, we will determine how metabolites of nutritional fatty acids can reduce sensitivity to environmental chemicals and disease. Our work emphasizes controlling chronic toxicities and disease such as pain, fibrosis, and Parkinson’s disease by modulating endoplasmic reticulum stress.

PI_NAMEs: HAMMOCK, BRUCE D (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Acids;analytical method;analytical tool;Antibodies;Biochemical;biochemical tools;Biological Assay;Biological Markers;Cells;Central Nervous System Diseases;Chemicals;Chemotherapy-Oncologic Procedure;Chronic;Chronic Disease;Collaborations;Communities;Coupled;depressive symptoms;Diabetes Mellitus;Diet;Dietary Intervention;Discipline;Disease;disease model;Education and Outreach;endoplasmic reticulum stress;Environment;environmental chemical;Environmental Exposure;Enzymes;Epoxide hydrolase;Epoxy Compounds;Excision;Fatty Acids;Fibrosis;flexibility;Health;Heart failure;Homeostasis;improved;inflammatory pain;inhibitor;Knowledge;Life Style;Lipids;Malignant Neoplasms;man;Mediator;Mental Depression;Mitochondria;Monitor;nanobodies;Neoplasm Metastasis;Non-Steroidal Anti-Inflammatory Agents;novel;nutrition;Nutritional;Omega-3 Fatty Acids;Omega-6 Fatty Acids;Organ;Outcome;Pain;painful neuropathy;Parkinson Disease;Pathologic;Pathway interactions;Pharmaceutical Preparations;pharmacologic;prevent;programs;Proteins;Reagent;Reporting;Research;response;Services;Stress;System;Testing;tool;Toxic effect;Toxin;Triclosan;tumor;Work

PROJECT_TITLE: Bioactive lipids as effectors and indicators of the deleterious effects of environmental exposure on chronic diseases


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SEATTLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The link between AD and age-related oral health problems is still poorly understood because changes in the cortical and biomechanical control of oromotor behavior in healthy aging and pathological aging have not been investigated. The proposed research is relevant to public health because disambiguating changes in the orofacial sensorimotor-cognitive neuronal network in healthy aging from pathological aging is expected to increase the understanding of potential contributing factors to the onset and progression of AD and the cortical areas that are vulnerable to AD. Thus, the proposed research is relevant to NIH’s mission of earlier identification of individuals who may be at risk for developing late-onset AD/ARD and to find potential avenues for the evaluation of pharmacological or cortical therapies for AD.

PI_NAMEs: ARCE-MCSHANE, FRITZIE ISIP (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: 3-Dimensional;Affect;afferent nerve;age related;age related changes;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease therapy;Anatomy;Animals;antagonist;Area;Ataxia;attenuation;Behavior;Biomechanics;Brain;Brain scan;Chronic;Cognitive;cognitive performance;Cranial Nerves;Deglutition;Deglutition Disorders;Dementia;density;Development;Early identification;effective intervention;Esthesia;Evaluation;Event;Exhibits;feeding;Feeding behaviors;Food;frontal lobe;Functional disorder;Goals;healthy aging;Impairment;Implant;Individual;innovation;Jaw;kinematics;Knowledge;Late Onset Alzheimer Disease;Learning;Link;Liquid substance;Macaca mulatta;Magnetic Resonance Imaging;Mastication;Measures;memory retrieval;Methods;Microelectrodes;Mission;Modeling;Morphology;Motor;Movement;Muscarinic Acetylcholine Receptor;Muscle;Nerve Block;nerve supply;neural;Neuromechanics;Neurons;nonhuman primate;normal aging;Oral;oral behavior;Oral health;orofacial;Outcome;Parietal Lobe;pathological aging;Pattern;Periodontal Diseases;Peripheral Nerves;Pharmaceutical Preparations;pharmacologic;Positioning Attribute;Prefrontal Cortex;prevent;Process;Property;Public Health;reconstruction;Research;response;Risk;Roentgen Rays;Scopolamine;Sensory;sensory input;sensory integration;Shapes;somatosensory;Structure;Surface;System;Tactile;Testing;Texture;Thinness;Tongue;Tooth Extraction;Tooth Loss;Tooth structure;Trigeminal nerve structure;United States National Institutes of Health

PROJECT_TITLE: Disambiguating natural aging from Alzheimer's disease through changes in oral neuromechanics

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;HIV/AIDS;Infectious Diseases;Pediatric;Prevention;Women's Health Research

ORG_CITY: MONROVIA

ORG_NAME: OAK CREST INSTITUTE OF SCIENCE

PHR: PROJECT NARRATIVE Current HIV prevention strategies that require daily oral dosing are burdensome to the user and, consequently, are often not followed. We will use state-of-the-art chemical synthesis, drug screening, biomedical device engineering, and pharmacology research to build on our previous successes in these areas and develop a long-acting, six-month implant system for sexual HIV prophylaxis. The proposed research is relevant to public health because it will lead to a rigorous selection of new, potent anti-HIV compounds that will be formulated for delivery from an implant system and tested in relevant animal models, with the potential to significantly improve clinical practice for HIV prevention and, possibly, treatment.

PI_NAMEs: BAUM, MARC MICHAEL (contact)

PROGRAM_OFFICER_NAME: PORTER, KRISTEN AMY

PROJECT_TERMS: Address;Adherence;Adverse reactions;Africa South of the Sahara;African;aged;AIDS prevention;Amino Acids;Animal Model;Anti-Retroviral Agents;Area;Award;Biological Assay;Biomedical Technology;chemical synthesis;clinical practice;Clinical Trials;Collaborations;Contracts;cytotoxicity;Decision Trees;design;Development;Devices;Dose;Drug Controls;Drug Delivery Systems;Drug Exposure;Drug Kinetics;drug release kinetics;Drug Screening;efficacy study;Engineering;Epidemic;experience;FDA approved;Female Adolescents;flexibility;Formulation;Frequencies;fundamental research;Future;Geometry;global health;Goals;Health Benefit;health organization;Health Personnel;HIV;HIV Infections;Human;humanized mouse;hydrophilicity;Hydrophobicity;Immune Targeting;Implant;implant design;improved;In Vitro;in vivo;in vivo evaluation;Individual;Infection;infection rate;inhibitor;Injectable;Injections;innovation;Integrase;Kinetics;Knowledge;Lamivudine;Lead;lead candidate;Libraries;Modality;Modeling;Mus;Names;nanoparticle;next generation;novel;Nucleosides;Oral;Parents;particle;Patients;Penetration;Peptides;Persons;Pharmaceutical Preparations;Pharmacology;Phase;Population Heterogeneity;pre-exposure prophylaxis;preclinical safety;Predisposition;preference;prevent;Prevention;Prevention strategy;Prodrugs;Property;prophylactic;Prophylactic treatment;prototype;Public Health;Receptor Cell;Recording of previous events;Rectum;Regimen;Research;Research Personnel;response;Reverse Transcriptase Inhibitors;Risk;Safety;safety study;scale up;Science;Sheep;simulation;South Africa;subcutaneous;success;System;Tail;Technology;technology platform;Testing;Therapeutic;Vagina;Viral;young woman

PROJECT_TITLE: Sustained Release of Potent Antiviral Prodrugs for HIV Prevention

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LONG BEACH

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA STATE UNIVERSITY LONG BEACH

PHR: Project Narrative There is a dire need in developing new molecular paradigms leading to drugs with increased selectivity, min- imizing undesired adverse effects, drug resistance, and environmental toxicity. Photopharmacology increases drug selectivity by using controlled light-activation of a drug at a given time and location in the body. We will use computational methods to study the membrane disruption mechanism of light-driven molecular nanomotors and optimize their molecular structure, leading to the next generation of nanomotors that can be used in pho- topharmacology for treatment of cancer, antibiotic resistant bacteria, and for controlled drug delivery through nanolipids.

PI_NAMEs: TAPAVICZA, ENRICO  (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: absorption;Address;Adverse effects;Affinity;Antibiotic Therapy;Bacterial Antibiotic Resistance;Binding;Biological;cancer cell;cancer therapy;Cell Death Induction;Cell membrane;Cells;chemotherapy;clinical application;Clinical Research;Collaborations;Communicable Diseases;Computer Models;Computer Simulation;Computer software;Computing Methodologies;design;Development;Drug Controls;Drug Delivery Systems;drug development;Drug resistance;Drug usage;Employment;experimental study;functional group;Gases;Generations;Goals;high throughput screening;improved;in silico;insight;irradiation;Isomerism;Light;light intensity;lipid nanoparticle;Location;Machine Learning;machine learning algorithm;Malignant neoplasm of prostate;Measures;mechanical properties;Mechanics;Mediating;Membrane;Membrane Lipids;Methods;Modality;Modernization;Modification;Molecular;molecular dynamics;molecular mechanics;Molecular Structure;Motor;nano;Nature;next generation;novel strategies;Nuclear;Operative Surgical Procedures;Patients;Penetration;Perforation;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phospholipids;Photons;Phototoxicity;pi bond;Process;Property;quantum;Quantum Mechanics;Radiation;Radiation induced damage;Rotation;side effect;simulation;Structure;System;Techniques;Technology;Testing;Therapeutic;Time;Tissues;Toxic effect;Training;two-photon;ultraviolet;Ultraviolet Rays;Work

PROJECT_TITLE: In Silico Study and Optimization of Molecular Nanomotors for Membrane Photopharmacology


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because medications are vital for long term management of human immunodeficiency virus (HIV) and medical and mental health conditions which are common in people with HIV. Prescription cap policies imposed on our most vulnerable populations, such as low income Medicaid beneficiaries, may force them to go without treatments or decide between which treatments to use. Ultimately, these decisions can have adverse effects on their health and the responsible allocation of public funds.

PI_NAMEs: GALARRAGA, OMAR ;SHIREMAN, THERESA I. (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Adoption;Adverse effects;adverse outcome;Affect;Aging;Angiotensins;antagonist;antiretroviral therapy;beneficiary;Budgets;Cardiovascular Diseases;Caring;CD4 Lymphocyte Count;Chronic;Chronic Disease;comorbidity;cost;Cost Control;cost outcomes;Country;Data;design;Diabetes Mellitus;Drug Costs;Drug Prescriptions;Economics;Enrollment;Ensure;Equilibrium;Evaluation;Expenditure;experience;Face;Funding;Goals;Grant;Health;health care service utilization;Health Services Accessibility;HIV;HIV Seronegativity;Hospitals;Hyperlipidemia;Hypertension;Indigent;Infection;Infrastructure;insight;Investments;Lead;Learning;Life;Life Expectancy;Literature;Low income;Medicaid;Medical;Medicare Part A;Medicare/Medicaid;medication compliance;Mental Health;Metformin;multiple chronic conditions;National Institute of Mental Health;Natural experiment;non-drug;Opportunistic Infections;Outcome;Patients;Persons;Pharmaceutical Preparations;Policies;Population;prescription drug costs;pressure;Prevalence;Price;programs;Public Assistance;Public Health;Publishing;rational design;Renin;Research;Risk;safety net;Savings;severe mental illness;Texas;therapy adherence;transmission process;Viral Load result;Vulnerable Populations;Work

PROJECT_TITLE: Impact of Prescription Caps on Health Outcomes in People Infected with HIV

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Bioengineering;Hematology

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: The Medical Physician Engineers, Scientists, and Clinicians Preparatory program [MPESC-Prep] (pronounced `em-pesk') will establish a multifaceted training program designed to ensure talented, diverse high school and college students are exposed to opportunities for professional development and mentorship during STEM training to pursue formal education and training in the prevention and treatment of cardiovascular, pulmonary, and hematologic conditions.

PI_NAMEs: CLAPP, DAVID W (contact);SORANNO, DANIELLE ELISE

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: African American;African American population;Awareness;Bioinformatics;Biology;Cardiovascular system;career;Charge;Clinical;college;Communities;design;Development;Discipline;Disease;Doctor of Medicine;Doctor of Philosophy;Educational Curriculum;Engineering;Enrollment;Ensure;Event;experience;Exposure to;Faculty;Fostering;Funding;Future Teacher;Goals;Growth;Health Policy;Heart Diseases;Hematological Disease;Hematology;high school;Hispanic;implementation evaluation;improved;Individual;innovation;insight;Institution;interest;Laboratories;Laboratory Research;Latinx;Leadership;Logic;Lung;Lung Diseases;Manuscripts;Measurable;Measures;Mediator;Medical;Medicine;meetings;member;Mentors;Mentorship;Methodology;Methods;Minority;minority student;Mission;Modeling;National Heart, Lung, and Blood Institute;next generation;Nursing Faculty;Outcome;Output;patient population;Patients;peer coaching;Peer Group;Physicians;Population;Postdoctoral Fellow;Prevention;Process;programs;Publications;racial diversity;recruit;Reproducibility;Research;Research Ethics;Science;Science, Technology, Engineering and Mathematics;Scientist;Self Efficacy;Series;STEM field;Students;success;summer internship;Talents;Training;Training and Education;Training Programs;translational impact;Trust;undergraduate education;undergraduate student;United States;United States National Institutes of Health;Universities;university student;Work

PROJECT_TITLE: The Medical Physician Engineers, Scientists, and Clinicians Preparatory Program [MPESC-Prep]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Vision impairment due to progressive loss of retinal ganglion cells and degeneration of optic nerve is among the most prevalent ocular diseases that affect world population. Our study aims at elucidating the DNA “blueprints” that are responsible for the activation of genes involved in retinal ganglion cell formation, which is critical for advancing cell-replacement strategies in affected patients.

PI_NAMEs: AL DIRI, ISSAM  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: 3-Dimensional;Affect;Architecture;ATOH7 gene;axon growth;Binding;Binding Sites;Biological Assay;Cell Differentiation process;cell replacement therapy;Cells;ChIP-seq;Chromatin;chromosome conformation capture;Cleavage Under Targets and Release Using Nuclease;Complex;CRISPR/Cas technology;Data;Degenerative Disorder;Development;Differentiation and Growth;Disease;DNA;Elements;Enhancers;Epigenetic Process;Essential Genes;experimental study;Expression Profiling;Eye diseases;Foundations;ganglion cell;Gene Activation;Gene Expression;gene regulatory network;Generations;Genes;Genetic;Genetic Enhancer Element;Genome;Genome Mappings;genome wide association study;Genomic DNA;Genomics;Glaucoma;Growth;Hi-C;Human;In Vitro;in vivo;Injury;innovation;insight;Knowledge;Link;Maintenance;Maps;Molecular;Mus;Neuropathy;next generation sequencing;Nuclear;Optic Nerve;Pathway interactions;Patients;Persons;Population;Proliferating;promoter;Regulation;Regulatory Element;Reporter Genes;Resolution;Retina;Retinal Degeneration;retinal ganglion cell degeneration;Retinal Ganglion Cells;retinogenesis;Role;SOX11 gene;SOX4 gene;Specific qualifier value;stem cell differentiation;stem cells;Techniques;Technology;Testing;Therapeutic;tool;transcription factor;Transcriptional Regulation;Transgenic Organisms;Transplantation;Untranslated RNA;Visual impairment;Work;YY1 Transcription Factor;Zebrafish

PROJECT_TITLE: Epigenetic basis of retinal cell fate determination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-F(02)M]


ADMINISTERING_IC: NS

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: EUGENE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project narrative This project investigates the local and large-scale neural circuit mechanisms that underlie the brain's ability to flexibly shift sensory processing depending on behavioral state and task demands. This flexibility is essential to normal cognitive function, and is disrupted in a range of psychiatric and neurological conditions.

PI_NAMEs: MCCORMICK, DAVID  (contact);NIELL, CRISTOPHER M

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TITLE: Brain States and Flexible Behavior


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: NARRATIVE As available genomic data continues to scale exponentially, speed and accuracy are crucial for computational pipelines that process large collections of eukaryotic and microbial genomic sequencing data. This project will develop the improved sequencing sketching algorithms that are necessary to enable the continued ability to gain biological and biomedical insights from this data in a practical and cost-effective way, with a particular focus on large-scale comparison of genomes in both the whole-genome and metagenomic settings. These new computational tools will enable understanding of the differences and evolution between human, model organisms, and other eukaryotes and improved analyses of metagenomic environments such as the human gut, which are necessary steps on the road to precision medicine.

PI_NAMEs: KINGSFORD, CARLETON LEE (contact);MARÇAIS, GUILLAUME

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TITLE: Improved genomic sketching for MUMmer and metagenomics

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: PSYCHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Selecting the most important information in a stimulus-rich world is a fundamental function that the brain must perform, and one that is essential to attention, decision-making, and perception. This proposal investigates the role of an evolutionarily conserved midbrain network in stimulus competition and spatial selection, with a focus on specialized cholinergic and inhibitory neurons within it. Results from this work will inform our understanding of how the brain processes complex sensory scenes and achieves stimulus selection, dysfunctions of which are associated with psychiatric disorders including ADHD, autism and schizophrenia.

PI_NAMEs: MYSORE, SHREESH P (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;analytical tool;anatomical tracing;Anatomy;Animals;Area;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;awake;Barn Owls;Behavior;Birds;Brain;Categories;Cell Nucleus;Cells;cholinergic;cholinergic neuron;cholinergic synapse;Code;Complex;Computer Models;Data;Decision Making;design;Distant;Electrophysiology (science);Environment;experimental study;extracellular;Feedback;Functional disorder;Glutamates;Head;Homologous Gene;in vivo;inhibitory neuron;Injections;insight;Iontophoresis;Logic;Mammals;Maps;Mental disorders;Methods;Midbrain structure;Monkeys;Muscarinics;neural;neural circuit;neuromechanism;Neurons;neuroregulation;neurotransmission;Neurotransmitters;Noise;novel;Pattern;Perception;predictive modeling;prevent;Process;Protocols documentation;receptive field;Regulation;Resistance;response;Role;Route;Runaway;Schizophrenia;Sensory;sensory stimulus;Signal Transduction;simulation;Site;Source;Stains;Stimulus;superior colliculus Corpora quadrigemina;Synapses;System;Tectum Mesencephali;Testing;Tracer;visual stimulus;Visuospatial;Work

PROJECT_TITLE: Stimulus competition and visuospatial selection: Neural circuit and computational mechanisms


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: NORTH CHICAGO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

PHR: Project Narrative This proposal is relevant to public health because there is a significant unmet need for new treatment approaches for anxiety disorders. The bed nucleus of the stria terminalis (BNST) has emerged as a key brain region translating prolonged exposure to uncertain threats into sustained fear; hence the factors that regulate the BNST activity have untapped potential as novel therapeutic targets. This proposal is relevant to NIMH mission because it explores the integrated role of vasopressin and oxytocin receptors in the BNST in fear processing and will contribute to better understanding of the neurobiology of anxiety disorders.

PI_NAMEs: DABROWSKA, JOANNA  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Affect;Amygdaloid structure;Anti-Anxiety Agents;Anxiety;Anxiety Disorders;anxious individuals;Automobile Driving;Behavior;Behavioral;behavioral response;Brain region;Cell Nucleus;conditioned fear;Corticotropin-Releasing Hormone;Cues;Data;design;Electrophysiology (science);experimental study;Exposure to;Female;foot;Fright;Funding;Genetic;Human;human imaging;Hyperactivity;imaging study;In Vitro;in vivo;innovation;Knowledge;Label;Laboratory Finding;male;Measures;Mediating;Mission;Modeling;National Institute of Mental Health;Neurobiology;Neurons;new therapeutic target;novel therapeutic intervention;optogenetics;Output;Oxytocin Receptor;patch clamp;Patients;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Play;Post-Traumatic Stress Disorders;postsynaptic;Process;Public Health;Rat Transgene;Rattus;receptor;Receptor Activation;response;Rodent;Role;Shock;Structure of terminal stria nuclei of preoptic region;Testing;Translating;transmission process;Vasopressin Receptor;Vasopressins

PROJECT_TITLE: The Integrated Role of Vasopressin and Oxytocin Receptors in the Modulation of BNST Activity and Fear Processing

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PHR: PROJECT NARRATIVE Our long-standing predoctoral Developmental Biology Training Program prepares creative and rigorous scientific leaders. Development biology research reveals mechanisms that go awry in congenital defects and adult diseases, including many cancers that arise from uncontrolled developmental programs. A detailed understanding of these diseases, and thus the rationale design of innovative diagnostics and therapeutics, depends on multifaceted training of the next generation of developmental biologists.

PI_NAMEs: DOE, CHRIS Q (contact);STANKUNAS, KRYN

PROGRAM_OFFICER_NAME: KOSTER, MARANKE IRENE

PROJECT_TERMS: Developmental Biology;Training Programs

PROJECT_TITLE: Developmental Biology Training Program


ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: NARRATIVE The Environmental Health Bioinformatics (EHB) T32 training program leverages the unique confluence of strengths in Data Science and Environmental Health Science at NC State to train scientists fluent in this critical interdisciplinary space. This data-intensive training program will produce scientists ready to meet the emerging challenges in environmental health research, including the ever-expanding exposome, understanding of variability between individuals, rational integration across massive data sets, and study designs that incorporate diverse community goals and needs.

PI_NAMEs: WRIGHT, FRED A. (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Bioinformatics;Training

PROJECT_TITLE: Graduate Training in Bioinformatics

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: 220.8 PROJECT NARRATIVE Latino men who have sex with men (MSM) have one of the steepest increases in new HIV diagnoses nationally, likely because intersectional stigma towards their ethnic, sexual, and gender identities (i.e. adherence to masculinity norms) uniquely amplify HIV risk in this population and impede uptake of effective HIV prevention strategies (i.e. routine HIV testing, PrEP use). Social network analysis is a highly innovative method for studying how intersectional stigma is experienced from members of Latino MSM’s social network and will be able to assess from whom and under what social contexts stigma reduction interventions can promote novel opportunities to improve HIV testing and PrEP use among Latino MSM to reduce HIV incidence in this group.

PI_NAMEs: SMITH, LARAMIE RAE (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Accounting;Acculturation;Adherence;Adult;Affect;Age;AIDS prevention;California;Characteristics;community engaged intervention;community organizations;County;Data;density;Environment;Epidemic;Equipment and supply inventories;ethnic identity;Ethnic Origin;experience;Exposure to;Family;Family member;Fostering;Friends;Fright;Future;Gender;Gender Identity;Health;health disparity;HIV;HIV diagnosis;HIV disparities;HIV Infections;HIV risk;HIV Seronegativity;Homophobia;Human immunodeficiency virus test;improved;Incidence;Individual;innovation;Intervention;Latino;Masculine;Measures;Mediating;Medical Records;member;men who have sex with men;Methods;Newly Diagnosed;novel;Outcome;Pathway Analysis;Persons;poor health outcome;Population;pre-exposure prophylaxis;prevent;Prevention;Prevention strategy;primary outcome;Process;prospective;Provider;Public Health;Puerto Rico;racism;recruit;Research;resilience;response;sexual identity;Sexual Partners;Sexuality;Site;social;Social Environment;Social Network;social relationships;social stigma;Social support;Source;Stigmatization;United States National Institutes of Health;uptake;US State;Work

PROJECT_TITLE: NEXUS: A novel social network approach to study the effects of intersectional stigma on HIV prevention among Latino MSM


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Pediatric

ORG_CITY: MADISON

ORG_NAME: GODX, INC.

ORG_STATE: WI

PHR: Project Narrative According to the World Health Organization, there are 1.7 billion cases of diarrheal diseases every year and approximately 1.5 million children’s deaths. The rapid identification of the pathogens that cause infectious diarrheal disease at the point-of-care (POC) may save lives and improve health outcomes by enabling prompt treatment with appropriate drugs. We propose the development of a low-cost, point-of-care stool sample preparation and DNA amplification and detection device to identify which pathogens are causing the infectious diarrhea so that patients can be treated at the clinician's office with the right drugs, right away even in resource-limited settings.

PI_NAMEs: KIM, CHANG HEE  (contact)

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: 5 year old;amplification detection;Bacteria;bile salts;Biological Assay;Campylobacter;Cause of Death;Cell Culture Techniques;Centrifugation;Cessation of life;Chemistry;Child;Clinical;Clinical Research;cognitive development;commercialization;Complex;Contractor;cost;design;Detection;detection assay;Development;Devices;Diagnostic;Diarrhea;diarrheal disease;DNA;DNA amplification;Docking;Dysentery;effective therapy;efficacy validation;Electronics;Elements;Engineering;Enteral;Environment;Exodeoxyribonuclease III;Feces;follow-up;Freeze Drying;Future;Gastroenteritis;gastrointestinal;Growth and Development function;Health;Heating;high risk;improved;Industry Standard;inhibitor;instrument;Intake;isothermal amplification;Laboratories;Lateral;lateral flow assay;Legal patent;Life;Manuals;manufacture;Mechanics;Methods;microdevice;mortality;Motor;nucleic acid detection;Nucleic Acids;Outcome;Output;Paper;Particulate;pathogen;Pathogen detection;pathogenic bacteria;Patients;Pharmaceutical Preparations;Phase;Plant Resins;point of care;point of care testing;Preparation;Price;Primary Care;Process;Pump;Resource-limited setting;Salmonella;Sampling;Sensitivity and Specificity;Shigella;Signal Transduction;Small Business Innovation Research Grant;Solid;stool sample;Swab;Technology;Temperature;Testing;Time;urgent care;Validation;Visual;World Health Organization

PROJECT_TITLE: Rapid, Handheld, Point-of-Care Stool Sample-prep Device for the Extraction and Detection of Nucleic Acid from Diarrheal Pathogens


NIH_SPENDING_CATS: Cancer;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

PHR: Project Narrative EBV-associated cancers represent an important unmet medical need. New therapeutic strategies are required to improve patient outcomes. We have developed small molecules inhibitors to EBNA1 to treat EBV latent infection driving EBV-associated cancers. We now propose to better understand how tumor cells respond to these inhibitors and enhance their efficacy by rational combinatorial therapies and structure-based chemical modifications.

PI_NAMEs: MESSICK, TROY E (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Animal Model;anticancer activity;Antineoplastic Agents;Apoptosis;Automobile Driving;Basic Science;Binding;cancer therapy;cancer type;carcinogenesis;cell growth;Cell model;Cell Proliferation;Cell Survival;cell type;Chemicals;chemotherapeutic agent;chemotherapy;Cisplatin;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Data;Development;Disease;DNA Binding;DNA Binding Domain;Drug Design;efficacy evaluation;Elements;endonuclease;Epstein-Barr Virus latency;Epstein-Barr Virus-Related Malignant Neoplasm;Fluorouracil;Foundations;Gene Expression;Generations;Genetic;Genome;Goals;Growth;Human;Human Herpesvirus 4;immune checkpoint;Immune checkpoint inhibitor;immune function;improved;in vivo evaluation;inhibitor;insight;Investigation;latent infection;Latent virus infection phase;Ligands;Malignant Neoplasms;Mediating;Medical;Medicine;Modeling;Modification;Molecular;multicatalytic endopeptidase complex;Mus;neoplastic cell;next generation;novel therapeutic intervention;novel therapeutics;Nuclear Antigens;Nuclear Protein;Oncogenic Viruses;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Pharmaceutical Preparations;Pharmacogenomics;programs;Property;Radiation;Recording of previous events;recruit;Reporting;Resolvase;response;Site;small hairpin RNA;small molecule;small molecule inhibitor;small molecule therapeutics;standard of care;Structure;synergism;targeted agent;Testing;Therapeutic;Therapeutic Agents;transcriptomics;Translational Research;Treatment Efficacy;tumor;tumor growth;tumorigenesis;Ubiquitin;ubiquitin-protein ligase;Viral;Viral Genes;Viral Genome;Viral Proteins;Virus;Work

PROJECT_TITLE: Drugging EBNA1 to Treat EBV-Associated Cancers

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHIATRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Women are at greater risk for developing cognitive impairment compared to men, implicating a role for estradiol. While studies indicate that psychosocial stress exposure, including social adversity, increases risk for deficits in executive function, the mechanisms underlying this risk remain unknown. The current study aims to address this gap in knowledge by characterizing the effects of social status on estradiol’s ability to modulate neuroinflammation and cognitive and memory function in females.

PI_NAMEs: ALVARADO, MARIA C;MICHOPOULOS, VASILIKI  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acetamides;Address;Adverse event;Aftercare;Age;Age-associated memory impairment;aged;Aging;aging related;Animal Model;Attenuated;Behavior;Behavioral;Behavioral inhibition;behavioral outcome;Brain;Brain region;C-reactive protein;Cerebrospinal Fluid;Chronic;Chronic stress;Clinical Data;Cognition;Cognitive;Cognitive aging;Cognitive deficits;Data;Estradiol;executive function;experimental group;Experimental Models;Exposure to;extend lifespan;falls;Female;flexibility;Fluorine;Future;Gene Expression Regulation;glial activation;health disparities in women;Hippocampus;Human;Immune;Impaired cognition;improved;Individual;Inflammation;Inflammatory;inflammatory marker;insight;Interleukin-6;Intervention;Knowledge;Label;life span;Macaca mulatta;Measures;Memory;men;Microglia;Modeling;Monkeys;neurobehavioral;Neurobiology;neuroimaging;neuroinflammation;neurotransmitter release;nonhuman primate;novel;Outcome;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Physiological;Positioning Attribute;Positron-Emission Tomography;pre-clinical;Prefrontal Cortex;Prevention;Process;Psychosocial Stress;reproductive;Risk;Role;Scanning;Signal Transduction;Site;social;social adversity;Social Environment;social group;Social status;spatial memory;Stress;stressor;Testing;tool;translational model;Treatment/Psychosocial Effects;Woman;Work

PROJECT_TITLE: The role of stress exposure on estradiol-induced changes in neuroinflammation and cognition

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Psilocybin is a serotonergic psychedelic that may have beneficial action for mental illnesses. In this project, we characterize how psilocybin influences the formation of dendritic spines and how the structural plasticity may depend on the expression on serotonin receptor subtypes and differ across cell types in the frontal cortex of mice. The results may provide clues into how psilocybin modifies brain function.

PI_NAMEs: KWAN, CHUN-HAY ALEX  (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: anti-depressive agents;antidepressant effect;Apical;Architecture;Attention;Behavior;Behavioral;Biological;Brain;cell type;Chronic stress;Cognition;conditional knockout;Conscious;Dendritic Spines;density;Dose;early phase clinical trial;experimental study;Exposure to;frontal lobe;Genetic;Goals;Half-Life;Hallucinogens;Head;hippocampal pyramidal neuron;HTR2A gene;Image;in vivo;insight;Ketamine;Knock-out;Major Depressive Disorder;Measures;Medial;Mediating;Mental disorders;Moods;Mus;Neocortex;neural;neurobiological mechanism;Neuronal Plasticity;Neurons;neuropsychiatric disorder;novel;optical imaging;Perception;Psilocybin;Pyramidal Tracts;receptor;Resolution;response;retrograde transport;Rodent;Series;serotonin receptor;Serotonin Receptor 5-HT2A;Serotonin Receptor 5-HT2C;Signal Transduction;Stress;Structure;Testing;Therapeutic;two photon microscopy;two-photon;Vertebral column;Virus;Visualization

PROJECT_TITLE: Cellular basis of psilocybin actions in frontal cortex

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: UTAH WRHR PROGRAM NARRATIVE: The Utah WRHR Program represents a convergence of experienced and successful faculty mentors with a substantial Scholar candidate pool of well-qualified junior clinician-scientists creating a highly-supportive career- development infrastructure. The Utah WRHR Program will continue to prepare clinical and translational research Scholars to lead research programs that will improve women's health across the life course.

PI_NAMEs: SILVER, ROBERT M. (contact)

PROGRAM_OFFICER_NAME: MAZLOOMDOOST, DONNA

PROJECT_TERMS: Address;Advisory Committees;Appointment;career;career development;Clinical;Clinical Sciences;clinical training;Communities;Development Plans;Dimensions;Discipline of obstetrics;Doctor of Philosophy;experience;Extramural Activities;Faculty;Fellowship;Funding;Future;Gynecologist;Gynecology;Health;Health Sciences;Institution;Medical Faculty;member;Mentors;Mentorship;Modeling;next generation;peer;Peer Review;peer support;Positioning Attribute;post-doctoral training;Principal Investigator;Program Development;programs;recruit;Research;Research Personnel;Resources;Scientist;senior faculty;Silver;success;Time;Training;Translational Research;United States National Institutes of Health;Universities;Utah;women's reproductive health

PROJECT_TITLE: Utah's Women's Reproductive Health Research Career Development Program


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Genetic epilepsy has a strong linkage to loss of function of GABAA receptors, the primary inhibitory ion channels in the central nervous system. Numerous clinical variants cause protein misfolding and reduced functional surface expression of GABAA receptors. Here, we propose to elucidate the molecular mechanism of GABAA receptor biogenesis and use the principles acquired to correct the function of pathogenic variants, representing a novel strategy to treat epilepsy.

PI_NAMEs: MU, TINGWEI  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Address;Anticonvulsants;ATF6 gene;Autophagocytosis;Binding;Biogenesis;Biological Assay;Calnexin;Cell membrane;Cellular Assay;Central Nervous System;Clinical;Complex;Data;Defect;Degradation Pathway;Development;disease model;Electrophysiology (science);Endoplasmic Reticulum;Epilepsy;Equilibrium;experimental study;Family member;Fluorescence;Funding;gamma-Aminobutyric Acid;Genetic;Heat-Shock Proteins 70;human induced pluripotent stem cells;Image;Induced pluripotent stem cell derived human neuron;Integral Membrane Protein;Ion Channel;loss of function;Lysosomes;Membrane;Molecular;Molecular Chaperones;multicatalytic endopeptidase complex;novel strategies;novel therapeutic intervention;patch clamp;Pathogenicity;Pathway interactions;Patients;pharmacologic;Pharmacotherapy;Polysaccharides;Productivity;protein degradation;protein folding;protein misfolding;Proteins;Proteomics;proteostasis;Publications;receptor;Receptor-Interacting Protein;Resistance;response;small molecule;Surface;trafficking;Ubiquitination;Variant;zinc-binding protein

PROJECT_TITLE: Understanding GABAA receptor protein folding and misfolding

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: WORCESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a global health threat. We will assess how lung metabolic stress and hypoxia lead to T cell dysfunction and impair immunity. Metabolic interventions that rescue T cell function will be tested as a therapeutic strategy.

PI_NAMEs: BEHAR, SAMUEL M (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Alcoholism;Animal Model;Antibodies;Bacillus;Bacteria;cancer therapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Cell surface;Cellular Immunity;Cellular Metabolic Process;Cessation of life;Chronic;Clinical;Containment;Coupled;Data;Development;Diabetes Mellitus;Disease;Equilibrium;exhaust;exhaustion;experimental study;Failure;Flow Cytometry;Functional disorder;global health;Goals;Granuloma;Growth;Homeostasis;Human;Hypoxia;Immune;Immunity;Immunooncology;Impairment;improved;In Vitro;in vivo;Infection;insight;Intervention;Knowledge;Lead;Lesion;Lung;Malignant Neoplasms;Malnutrition;Maps;Mediating;Metabolic;Metabolic stress;Metabolism;Mitochondria;Modeling;mouse model;Mouse Strains;Mus;Mycobacterium tuberculosis;neovascularization;Outcome;Pathogenesis;Patients;Persons;Pharmaceutical Preparations;Phenotype;Prediction of Response to Therapy;Predisposition;preservation;prevent;programmed cell death protein 1;Proliferating;prophylactic;Pulmonary Tuberculosis;receptor;Receptor Signaling;Recrudescences;Reporter;Resistance;Resolution;Risk;Risk Factors;Role;single-cell RNA sequencing;Smoking;stressor;T cell receptor repertoire sequencing;T cell response;T-Cell Activation;T-Cell Development;T-Lymphocyte;Testing;Therapeutic;Tuberculosis;tuberculosis immunity;tumor;Tumor Immunity;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Work

PROJECT_TITLE: Hypoxia,  tuberculosis, and T cell dysfunction

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Rare Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative:  Neurobrucellosis is the most morbid complication of Brucella infection in humans, but studies on neurobrucellosis are scarce due to the lack of relevant animal models. Here, we present the first murine models of neurobrucellosis in which Brucella is able to colonize the brain, induce inflammation, and impair neurologic function. In this proposal, we will investigate pathways involved in the pathogenesis of neurobrucellosis, and potentially identify targets for complementary therapeutics for neurobrucellosis.

PI_NAMEs: ATEYA, MOSTAFA F (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Adoptive Transfer;Animal Model;Animals;Anti-Bacterial Agents;antimicrobial;blood-brain barrier crossing;blood-brain barrier permeabilization;Brain;brain dysfunction;Brucella;Brucellosis;cell type;Cells;Central Nervous System;Central Nervous System Infections;Compensation;Complement;Complement Activation;complement pathway;Complication;Control Animal;Data;Defect;Development;Disease;Gene Expression Profile;Gene Expression Regulation;Goals;Human;IFNAR1 gene;IFNGR1 gene;Immune;Impairment;In Vitro;Infection;Infection Control;Inflammation;Inflammatory;Interferon Type I;Interferon Type II;Interferons;Lymphoid Cell;Macrophage;Mediating;Meningitis;Microglia;Modeling;mouse model;Mus;Myelogenous;neglect;Nervous System Physiology;Neurologic;Neurologic Dysfunctions;neuron apoptosis;Pathogenesis;pathogenic bacteria;Pathology;Pathway interactions;Polysaccharides;Predisposition;Production;protective effect;Resistance;response;Role;Signal Pathway;Signal Transduction;STAT1 gene;STAT2 gene;synaptic pruning;T-Lymphocyte;Testing;Therapeutic;transcription factor;transcriptome sequencing;type I interferon receptor;Up-Regulation;Zoonoses

PROJECT_TITLE: Interferons in Neurobrucellosis

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence;Patient Safety;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project narrative Whole genomic sequencing (WGS) surveillance has been shown to detect serious outbreaks that are otherwise unidentified by traditional infection prevention methods. Bacterial plasmids often contain multiple genes that encode for antimicrobial resistance and be readily transferred between bacterial species, which can then be transmitted between patients (transfer to transmission [T2T]), events that are not detected by traditional genomic epidemiologic methods. In this application, we propose to develop the methods for detecting T2T events and determine their utility as part of WGS surveillance in the hospital.

PI_NAMEs: HARRISON, LEE H (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: acute care;Algorithms;anti-microbial drug;Antimicrobial Resistance;Bacteria;bacterial genome sequencing;Bioinformatics;bioinformatics pipeline;Centers for Disease Control and Prevention (U.S.);cost effective;data mining;detection method;detection platform;Discipline of Nursing;Disease Outbreaks;Electronic Health Record;Endoscopes;Environment;Epidemiologic Methods;Event;experience;Genes;genomic epidemiology;Genomics;Goals;Healthcare Systems;healthcare-associated infections;hospital care;Hospitalization;Hospitals;Hybrids;improved;Incidence;Infection Control;Infection prevention;Infectious Disease Epidemiology;Infrastructure;innovation;Interruption;Intervention;Investigation;Laboratories;Machine Learning;machine learning algorithm;Medical Device;Methods;microbial genomics;Mining;Monitor;novel;pathogen;patient safety;Patient-Focused Outcomes;Patients;Plasmids;Prevalence;prevent;Procedures;real time monitoring;Reporting;Research;Route;Running;Sampling;sequencing platform;Services;Site;success;System;Time;tool;transmission process

PROJECT_TITLE: Tracking plasmid spread and transmission in the hospital: A novel tool for infection prevention and control

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Data Science;Dementia;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative We will expand a research infrastructure to support the integration of nursing care plan data to large complex datasets with patient and clinical level data. Through this expanded research infrastructure, we will be able to create predictive models with nursing, clinical, and environmental data for unplanned readmissions of older adults with Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias. We are confident that this study will be a model for the development of new research-data infrastructure and will allow us to learn the improvements nurses, physicians, and other providers can make to prevent readmissions.

PI_NAMEs: KEENAN, GAIL M;MACIEIRA, TAMARA G.R. (contact);YAO, YINGWEI

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: age group;aged;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;application programming interface;Care given by nurses;Caring;Clinical;Clinical Data;clinical development;Clinical Research;Code;Collaborations;complex data;cost;Data;Data Analytics;Data Element;data infrastructure;data integration;data pipeline;Data Set;data standards;Development;Discipline of Nursing;Disease;Electronic Health Record;Elements;Florida;follow-up;Goals;Health;Health system;Heart Diseases;hospital care;hospital readmission;Hospitalization;hospitalization rates;improved;Infrastructure;Intervention;large datasets;Learning;Link;machine learning model;Malignant Neoplasms;Maps;Medical Care Team;Methodology;model development;Modeling;multidisciplinary;Natural Language Processing;Nurses;Nursing Care Plans;nursing intervention;older adult;Outcome;Pain;Patient Readmission;Patient-Focused Outcomes;Patients;Persons;Phase;Physicians;Population;predictive modeling;prevent;primary care provider;programs;prototype;Provider;readmission rates;Registered nurse;Research;Research Infrastructure;Risk;Source;Standardization;statistics;Technology;Terminology;Testing;Time;Translating;Trust;Unified Medical Language System;United States;Universities;University resources;Vocabulary

PROJECT_TITLE: Harmonizing and Integrating Nursing Data into Multidisciplinary Datasets to Evaluate Hospital Care and Readmissions of Older Adults with Alzheimer's Disease-Related Dementias

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Multiple Sclerosis is the most common form of non-traumatic neurologic disability among young adults with a world-wide prevalence of ~2.5 million and requires an environmental trigger for disease to occur. We have identified a statistical association between epsilon toxin producing strains of Clostridium perfringens and Multiple Sclerosis. In this application we will determine the cellular/tissue targets of epsilon toxin, compare and contrast the clinical phenotype, immunopathology, and neuropathology of experimental autoimmune encephalomyelitis induced by epsilon toxin versus pertussis toxin, identify genes induced or suppressed by these toxins, and determine the function of these genes in overcoming CNS immune privilege using endothelial cell specific loss-of-function mutant mice.

PI_NAMEs: VARTANIAN, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Active Immunization;adaptive immune response;Animal Model;Autoimmunity;autoreactivity;Binding;Bioinformatics;Biological Assay;Blood;Blood - brain barrier anatomy;Blood Vessels;Brain;Brain Stem;Candidate Disease Gene;Catalogs;Cell Separation;Cell Surface Receptors;Cells;cellular targeting;Cerebellum;Clinical;clinical phenotype;clinically relevant;Clostridium perfringens;Clostridium perfringens epsilon toxin;CNS autoimmunity;Confocal Microscopy;Demyelinations;diagnostic tool;Disease;DNA Sequence Alteration;Endothelial Cells;Endothelium;Endotoxins;Environmental Risk Factor;Event;Experimental Autoimmune Encephalomyelitis;Experimental Models;Flow Cytometry;Frequencies;Functional disorder;gain of function;Gene Deletion;gene function;gene induction;Gene Transfer;Genes;Genetic Risk;Goals;gut microbiome;high dimensionality;Human;Immune;immune cell infiltrate;Immunohistochemistry;immunopathology;Individual;Inflammatory;innovation;Knockout Mice;Lesion;Leukocyte Trafficking;Leukocytes;Localized Lesion;Location;loss of function;loss of function mutation;Lymphocyte;Mediating;Meningeal;Messenger RNA;migration;Modeling;Molecular;Molecular Target;Multiple Sclerosis;multiple sclerosis patient;Mus;Mutant Strains Mice;Myelin;Neuroanatomy;Neurological disability;neuropathology;novel diagnostics;Pathogenicity;Pathology;Pathway interactions;Persons;Pertussis Toxin;Phenotype;postcapillary venule;Prevalence;Process;Prosencephalon;Proteins;receptor;RNA;Role;Sampling;single-cell RNA sequencing;Spinal Cord;T-Lymphocyte;Techniques;Testing;therapeutic evaluation;therapeutic target;Time;Tissues;Toxin;Transcriptional Regulation;transcriptome sequencing;Wild Type Mouse;Work;young adult

PROJECT_TITLE: Immune Privilege, CNS Autoimmunity, and Clostridium perfringens Epsilon Toxin

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative This project aims to investigate the contributions of c-di-GMP and its effector protein PlzA to gene regulation and motility of Borrelia burgdorferi at different moments of its enzootic cycle. Results from these studies will increase our understanding of how B. burgdorferi responds to vector and host signals to regulate expression of virulence genes. Our findings may lead to the development of novel strategies to curtail the spread of Lyme disease, alleviating the impact of this disease in humans.

PI_NAMEs: CAIMANO, MELISSA J (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Address;Adherence;Affect;Anabolism;Arbovirus Infections;Attenuated;Back;Bacteria;Bacteria sigma factor KatF protein;Basement membrane;beta barrel;Binding;Biological;Biosensor;Blood;Borrelia burgdorferi;Cell Physiology;Communicable Diseases;Complex;cytosolic receptor;design;Development;Diagnosis;diguanylate cyclase;dimer;Disease;Divorce;DNA Binding;DNA-Protein Interaction;EMSA;enzootic;Epithelium;experience;experimental study;feeding;Gelatin;Gene Expression;Gene Expression Regulation;Genetic Transcription;Guanosine Monophosphate;Human;In Vitro;Infection;insight;Ixodes;Larva;Lead;Ligands;Lyme Disease;Mammals;Mediating;Midgut;migration;Molecular Conformation;Monitor;Motility;Motor;Mus;mutant;Nature;novel;novel strategies;Nymph;Operon;Order Spirochaetales;Organism;pathogen;Pathway interactions;Periodicity;Phase;Phenocopy;Phenotype;pleiotropism;posttranscriptional;Process;Production;promoter;protein protein interaction;Proteins;Research Personnel;response;Rodent;Role;Rotation;Running;Salivary Glands;Second Messenger Systems;Sigma Factor;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;Speed;Structure;System;Tertiary Protein Structure;tick feeding;tick transmission;Ticks;Tissue-Specific Gene Expression;Transcription Coactivator;transmission process;United States;vector;virulence gene;Virulent

PROJECT_TITLE: Elucidating the contributions of c-di-GMP and PlzA to tick- and mammalian host-adaptation in Lyme disease spirochetes

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Individuals living with HIV continue to experience cognitive symptoms that impact daily function despite treatment with antiretroviral therapy and research thus far has heavily focused on cognitive impairment rather than earlier time points prior to the development of impairment. Additionally, our findings show that decreased myelin, a key component of white matter in brain, may be injured in individuals living with HIV at risk for developing cognitive impairment. We will focus on a unique cohort of young adults, ages 18 to 34 years, living with HIV and evaluate the pathology underlying brain injury in this cohort using a new imaging sequence that focuses on myelin content, blood markers of inflammation, and standardized cognitive assessments over time to better understand the cognitive trajectory and risk factors for suboptimal cognitive performance in young adults living with HIV.

PI_NAMEs: PATEL, PAYAL  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Accounting;Address;Adult;adverse childhood events;Affect;Age;age group;Age Years;Animals;antiretroviral therapy;Attenuated;axon injury;Biological Markers;biopsychosocial;biopsychosocial factor;Blood;Blood Vessels;Brain;Brain Injuries;Cerebrum;Clinical Trials;Cognition;Cognition Disorders;Cognitive;cognitive performance;cognitive testing;cohort;comorbidity;Cross-Sectional Studies;daily functioning;Data;Demyelinations;Development;Diffusion Magnetic Resonance Imaging;Early intervention trials;Educational Status;Etiology;Exclusion;Executive Dysfunction;executive function;experience;follow-up;Health;high risk;HIV;HIV Infections;HIV-associated neurocognitive disorder;Image;Imaging Techniques;immune activation;Impaired cognition;Impairment;improved;in vivo;Incidence;Individual;Infection;inflammatory marker;injured;Knowledge;Liquid substance;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Mental Health;Methodology;monocyte;Multiple Sclerosis;Myelin;Myelin Water Imaging;myelination;Nervous System Trauma;Neurobehavioral Manifestations;neuroimaging;Neurologic;novel;older adult;Opportunistic Infections;Outcome;Participant;Pathologic;Pathology;Perinatal;Persons;pharmacologic;Phenotype;Plasma;Population;pre-exposure prophylaxis;preservation;Prevalence;prospective;Publishing;Questionnaires;Recording of previous events;Recovery;remyelination;Research;Risk;Risk Assessment;Risk Factors;sex;social health determinants;social stigma;Socioeconomic Status;Standardization;standardize measure;Statistical Models;therapeutic target;Time;Trauma;Viral;white matter;white matter change;white matter injury;Work;young adult

PROJECT_TITLE: Myelin Content and Cognitive Trajectories in Young Adults Living with Virally Suppressed HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: ATHENS

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Project Narrative Approximately 6-8 million people are infected with Trypanosoma cruzi, the etiologic agent of Chagas disease. Cardiomyopathy is the most frequent clinical manifestation of Chagas disease and is characterized by the development of scar tissue (fibrosis). We will explore whether polyphosphate released from the infective stages of T. cruzi is involved in the generation of fibrosis impacting the pathogenicity of the parasite.

PI_NAMEs: DOCAMPO, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Actins;Acute Myocarditis;Address;Adhesives;Affect;Americas;Binding;Blood Platelets;cancer cell;Cardiac;Cardiomyopathies;Cell membrane;Cell surface;Cells;Cessation of life;Chagas Disease;Chemotaxis;Chronic;chronic myocarditis;Cicatrix;Clinical;Collagen;coronary fibrosis;Deposition;Development;Elastin;Etiology;experimental study;extracellular;Extracellular Matrix;extracellular vesicles;Failure;Fiber;Fibroblasts;Fibronectins;Fibrosis;flexibility;Functional disorder;Generations;Glycosome;Heart Diseases;Heart failure;Heart Hypertrophy;Infection;Inflammation;Inflammatory;interstitial;Laminin;Life Cycle Stages;mast cell;Membrane Proteins;Molecular;Myofibroblast;neutrophil;Organ;Orthophosphate;Parasites;Pathogenesis;Pathogenicity;Pathology;Persons;Pharmacotherapy;Polymers;Polyphosphates;Polyps;posaconazole;prevent;Production;Proteins;Proteoglycan;response to injury;Role;side effect;Signal Transduction;Signaling Molecule;Smooth Muscle;Stimulant;Stress Fibers;Structural Protein;Surface;Time;Tissues;Trypanocidal Agents;Trypanosoma cruzi;vaccine access;Vesicle;Work

PROJECT_TITLE: Polyphosphate and cardiac fibrosis by Trypanosoma cruzi

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioids;Substance Misuse

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE  Despite their prominent roles in the pathophysiology and treatment of pain, addiction and mood disorders, the mechanisms by which opioid receptors (ORs) control neural circuits and behavior remain poorly understood in large part due to limitations of classical pharmacological techniques which lack spatiotemporal control, subtype-specificity, pathway-specificity and targeting to genetically-defined cell types. In this proposal, we will develop a family of photopharmacological strategies for genetically-targeted optical control of native ORs to probe the cellular and circuit mechanisms of mu-OR-mediated anti-depressant treatment.

PI_NAMEs: LEVITZ, JOSHUA  (contact);TRAUNER, DIRK HARTWIG

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Acute;addiction;Agonist;Analgesics;antagonist;anti-depressive agents;Antibodies;antidepressant effect;azobenzene;Behavior;Behavioral;Behavioral Assay;beta-arrestin;Binding;Biology;Brain;brain cell;Brain region;Calcium;cell type;Cells;chemical synthesis;Chemicals;Chronic stress;Complex;conflict resolution;Coupling;Dangerousness;Darkness;Dependence;desensitization;design;Development;Disease;Disinhibition;Drug Addiction;Drug Targeting;Electrophysiology (science);Engineering;expectation;experimental study;Family;Fentanyl;Functional disorder;G-Protein-Coupled Receptors;Genes;GTP-Binding Proteins;Image;improved;In Vitro;in vivo;insight;interest;Interneurons;Label;Ligands;Light;Measures;Medial;Mediating;Mental Depression;Mental disorders;Methodology;Methods;Modification;Molecular;molecular dynamics;Molecular Probes;Mood Disorders;mood regulation;Moods;Morphine;mu opioid receptors;Mus;N-terminal;Naloxone;nanobodies;Nervous System;Nervous System Disorder;neural circuit;Neuromodulator;neuronal excitability;Neurons;neuroregulation;Opioid;Opioid agonist;Opioid Receptor;Optics;Pain management;pain sensation;Pathway interactions;Peptide Signal Sequences;Perception;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacology Study;Phase;photoactivation;Prefrontal Cortex;Process;rational design;receptor;Receptor Activation;receptor internalization;reward processing;Rewards;Role;Sampling;Sensory Process;side effect;Signal Transduction;Slice;small molecule;Somatostatin;spatiotemporal;Specificity;Structure;Synapses;System;targeted treatment;Techniques;temporal measurement;Testing;Therapeutic;Time;two-photon;Work

PROJECT_TITLE: Genetically-Targeted Photo-Pharmacology for Native Opioid Receptors


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative (relevance to public health) Myelin oligodendrocyte glycoprotein (MOG) antibody disease (MOGAD) is a newly identified syndrome that is characterized by circulating autoantibodies targeting MOG, yet the role of these autoantibodies in disease pathology is not understood. In order to effectively treat patients with MOGAD, we must understand the disease mechanisms, and importantly how they vary from patient to patient. Our investigation aims to define two major contributors to MOGAD pathology, both of which focus only on the specific cells and antibody molecules that make direct contributions to the disease; to that end, we propose to clone disease-causing autoantibodies and cells from patients and test them with a set of assays to define MOG autoantibody- mediated mechanisms, as means to ultimately predict treatment response, monitor disease progression, and enable personalized therapeutic decisions.

PI_NAMEs: O'CONNOR, KEVIN C (contact)

PROJECT_TERMS: Address;Adopted;Adult;Affect;Antibodies;antibody-dependent cell cytotoxicity;antigen binding;Antigens;aquaporin 4;Area;Astrocytes;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmune Process;Automobile Driving;autoreactive B cell;B cell repertoire;B cell therapy;B-Cell Antigen Receptor;B-Lymphocyte Subsets;B-Lymphocytes;Binding;biobank;Biological Assay;Bladder;care providers;CD19 gene;Cell-Mediated Cytolysis;Cells;Central Nervous System;central nervous system demyelinating disorder;Clinical;clinical phenotype;Clinical Trials;clinically relevant;Clonality;Cloning;Complement;Complement Activation;Complement Inactivators;Complement-Dependent Cytotoxicity;Complex Mixtures;Demyelinations;Detection;Diagnostic;Dimensions;Disease;disease model;Disease Progression;Elements;Epitope Mapping;experience;Experimental Designs;experimental study;Flow Cytometry;Frequencies;Gene Expression;glycosylation;Goals;high dimensionality;Human;human monoclonal antibodies;IgG autoantibodies;IgG1;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;immunopathology;Impaired cognition;In Vitro;Individual;Inflammatory;Infrastructure;Intestines;Investigation;Knowledge;Laboratories;Libraries;Measures;Mediating;Modeling;Molecular;Monitor;Monoclonal Antibodies;Motor;mouse model;MS4A1 gene;Multiple Sclerosis;Nature;Neuromyelitis Optica;novel;novel strategies;novel therapeutics;oligodendrocyte-myelin glycoprotein;pathogenic autoantibodies;Pathogenicity;Pathology;Patients;Peripheral Blood Mononuclear Cell;personalized therapeutic;Phenotype;Plasma Cells;Plasmablast;Prediction of Response to Therapy;Production;Property;Public Health;Qualifying;Recombinants;Relapse;rituximab;Role;Serum;single-cell RNA sequencing;Somatic Mutation;Specificity;Study of serum;Syndrome;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissue Stains;Tissues;tool;Visual;water channel;Work

PROJECT_TITLE: Defining the autoimmune mechanisms driving human MOG antibody disease pathology


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS

ORG_CITY: Los Alamos

ORG_NAME: TRIAD NATIONAL SECURITY, LLC

ORG_STATE: NM

PHR: Project Narrative This pilot study addresses HIV recombination, a critical problem in HIV epidemics and global disease surveillance. Through the development and validation of two new methods, we aim to address the limitations of the HIV recombination classification system and fulfill the knowledge and technology gaps needed for predicting virus recombination and emerging recombinant clusters to assist public health decision making.

PI_NAMEs: HUANG, HANWEN ;SONG, XIAO ;ZHANG, MING  (contact)

PROJECT_TERMS: Address;Anti-viral Agents;Classification;Data;data mining;Decision Making;Deposition;design;Detection;Development;Disease Progression;Disease Surveillance;Drug resistance;Epidemic;epidemiologic data;Epidemiology;Event;Evolution;experience;Family;Genbank;Genetic;Genetic Recombination;Genome;Geographic Locations;HIV;HIV Genome;HIV Infections;Human;Immune;improved;Individual;Investigation;Knowledge;Length;markov model;method development;Methods;Mutate;Mutation;novel strategies;Patients;Pilot Projects;Point Mutation;Population;Population Surveillance;Positioning Attribute;preference;Public Health;Publishing;Recombinants;Reporting;Research;Role;Sample Size;Sampling Biases;Shapes;Signal Transduction;statistical and machine learning;Statistical Methods;System;Technology;tool;Vaccines;Validation;Viral;Viral Genome;Virus

PROJECT_TITLE: A novel approach to pinpoint predisposed recombination regions in HIV for a global profile of HIV recombinants' occurrence and evolution

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Pediatric;Prevention;Rare Diseases;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Heart failure is the leading cause of death patients with congenital heart disease (CHD), and identification of those CHD survivors who are at-risk of heart failure is critical to improving morbidity and mortality. We will establish a community- based cohort of 600 CHD survivors, NC-DEFINE, to study the social and genetic determinants of heart failure. If successful, this study will aid in the identification of patients with CHD at-risk of HF so that interventions can be made.

PI_NAMEs: LANDSTROM, ANDREW P. (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Adult;Affect;Area;biobank;Black race;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular system;Cause of Death;Cells;Cessation of life;Clinical;Clinical Data;clinical encounter;clinical phenotype;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Communities;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;Counseling;Data;Databases;demographics;Development;Disparity;Early Diagnosis;Early Intervention;Engineering;Enrollment;Environmental Risk Factor;Ethnic Origin;exome sequencing;experience;Foundations;Frequencies;Future;Genes;Genetic;genetic analysis;Genetic Code;Genetic Determinism;Genetic Markers;Genetic Risk;genetic variant;Genomic DNA;Genomic medicine;Genomics;Geographic Information Systems;Goals;health care availability;health disparity;Health Services Accessibility;Heart;Heart failure;High Prevalence;high risk;improved;In Vitro;Individual;induced pluripotent stem cell;Intervention;Knowledge;life span;Link;Live Birth;low socioeconomic status;Maps;Measures;Medical;Metabolic;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Mutation;North Carolina;Operative Surgical Procedures;Outcome;Patients;Peripheral Blood Mononuclear Cell;Population;population based;Positioning Attribute;Prognosis;prospective;Race;rare variant;Records;repaired;Research;Risk;Risk Factors;Role;Sarcomeres;Sarcoplasm;Signal Transduction;Site;social;social determinants;social health determinants;socioeconomics;stem cell model;surveillance network;Survivors;Testing;Time;tool;United States;Universities;Variant;virtual model;Work

PROJECT_TITLE: Determining the genetic and social determinants of heart failure and mortality in patients with congenital heart disease

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]