ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Rural Health;Social Determinants of Health

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE This novel, timely, and theory-driven Food-Body-Mind intervention addresses the national emergency of mental health crises in early childhood. By targeting Head Start racially/ethnically diverse preschoolers from low-income backgrounds in both urban and rural areas, this intervention is expected to contribute toward reducing health disparities and promoting health equity, a major priority of the NIH and Healthy People 2030. If effective, it can be scalable to Head Start programs across urban and rural settings nationally with long-term sustainability benefits.

PI_NAMEs: LING, JIYING  (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: Address;Adolescence;Adult;Affect;aged;allostatic load;Anger;Antiinflammatory Effect;Anxiety;Behavior Disorders;Behavioral;behavioral health;Blood Pressure;Body fat;Body mass index;Brain;Caregivers;Child;Child Health;Child Rearing;Chronic stress;Cognition;community partners;comparison control;comparison intervention;Complementary Health;Conduct Disorder;Control Groups;coping;cost effective;COVID-19 pandemic;Data;Data Collection;Day Care;Day center care;deep breathing exercises;Depressed mood;Development;Diagnosis;disadvantaged background;Disease;early childhood;Eating;Eating Behavior;Eating Disorders;Educational Status;Emergency Situation;Emotional;Emotional disorder;emotional eating;Enrollment;ethnic diversity;Ethnic Origin;evidence base;experience;Family;follow-up;Food;Fostering;Fright;fruits and vegetables;Generations;Geography;Goals;Hair;Head Start Program;Health;health disparity;health equity promotion;Health Promotion;Healthy Eating;high risk;Home;Home environment;Hydrocortisone;improved;Income;innovation;Intake;Integrative Medicine;Intention;Intervention;intervention effect;Knowledge;Learning;Legal Guardians;Letters;Link;Literature;Longterm Follow-up;Low income;lower income families;marginalization;Measurement;Mediating;Mental Depression;Mental disorders;Mental Health;Michigan;Mind-Body Intervention;mindfulness;Modeling;Moods;Movement;neuroprotection;novel;Parents;peer;Persons;Phase;phase II trial;Physical activity;physical conditioning;Plants;population health;post intervention;primary outcome;Problem behavior;Procedures;Productivity;programs;Protocols documentation;Psyche structure;Race;racial diversity;Randomized;Randomized, Controlled Trials;Readiness;recruit;Reduce health disparities;Reporting;Research;Research Training;Residencies;Risk;Risk Reduction;Rural;rural area;rural setting;Schools;secondary outcome;Services;Site;skills;social skills;socioeconomic disparity;Socioeconomic Status;Stress;Stress and Coping;teacher;Testing;theories;Transact;United States National Institutes of Health;urban area;urban setting;usual care arm;Vulnerable Populations;Work;Yoga

PROJECT_TITLE: Food-Body-Mind Intervention: Promote whole child health

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Sleep Research

ORG_CITY: BLOOMINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Narrative The proper alignment of internal circadian clocks with the 24-hour rhythm of the environment is critical for human well-being. A central goal of chronobiology is to understand how the brain’s circadian clock center is organized and how it is modulated by environmental time-cues. Here we propose a continuation of a productive and impactful research program using Drosophila melanogaster to understand the mechanisms that circadian neural networks employ to create an endogenous sense of time and how these networks integrate environmental time-cues to ensure the proper coordination of the internal circadian system with external time.

PI_NAMEs: SHAFER, ORIE T (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TITLE: Network Properties of Circadian Clock Modulation and Entrainment

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE We have developed a non-infectious, self-replicative SARS-CoV-2 replicon system that is a safe and effective tool for antiviral screening and amenable to genetic engineering for studying drug resistance. We have identified a small molecule inhibitor of SARS-CoV-2 antiviral activity, and early medicinal chemistry efforts have optimized this lead. This project aims to further identify and characterize compounds toward the development of novel inhibitors against SARS-CoV-2 with potent, nanomolar antiviral activity.

PI_NAMEs: SARAFIANOS, STEFAN G (contact);WANG, ZHENGQIANG

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Active Sites;Address;Affect;Air;airway epithelium;analog;Anti-viral Agents;Binding;Biochemical;Biological Assay;Biophysics;Caco-2 Cells;Cell Line;cell preparation;Cells;Cessation of life;Collection;combat;Combined Modality Therapy;Coronavirus;COVID-19;COVID-19 mortality;cytotoxicity;Data;Development;Disclosure;Disease;Disease Outbreaks;drug candidate;drug discovery;Drug Kinetics;Drug resistance;Effectiveness;efficacy study;Enzyme Kinetics;experimental study;expression cloning;fitness;Fluorescence Microscopy;Generations;Genes;Genetic Engineering;Genomics;Grant;helicase;Hepatitis B Virus;Hepatitis C virus;high throughput screening;HIV-1;HIV-2;Human;improved;In Vitro;in vivo;Individual;Influenza;inhibitor;innovation;International;invention;Kinetics;Lead;lead optimization;Legal patent;Libraries;Liquid substance;Measurement;Measures;Metals;meter;miniaturize;Molecular;monolayer;mortality;mouse model;Mus;Mutation;nanomolar;Nonstructural Protein;novel;pandemic disease;Pharmaceutical Chemistry;Plasmids;Preparation;Proteins;Public Health;Published Comment;Publishing;remdesivir;Replicon;Reporting;Resistance;resistance mechanism;resistance mutation;RNA;SARS coronavirus;SARS-CoV-2 antiviral;SARS-CoV-2 B.1.1.7;SARS-CoV-2 B.1.351;SARS-CoV-2 CAL.20C;SARS-CoV-2 inhibitor;SARS-CoV-2 P.1;screening;Severe Acute Respiratory Syndrome;small molecule inhibitor;small molecule libraries;socioeconomics;stable cell line;success;synergism;System;Technology;Testing;Time;tool;Transfection;Untranslated Regions;Vaccines;Variant;Viral;viral entry inhibitor;Viral Physiology;Virus;Virus Diseases;Visualization;Washington;Work;ZIKA

PROJECT_TITLE: Discovery of SARS-CoV-2 antivirals using a replicon assay

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(02)]


ADMINISTERING_IC: MH

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE Therapeutic interventions, such as exposure therapy, reduce pathological fear in patients with anxiety disorders—but this fear reduction is often transient and vulnerable to relapse. The impermanence of extinction-based therapy is a major challenge to clinical interventions for a host of disorders, including anxiety and post-traumatic stress disorder. Therefore, the long-term goal of this project is to understand the neural substrates of extinction, particularly the specific brain circuits involved in the contextual retrieval of extinguished fear memories.

PI_NAMEs: MAREN, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Amygdaloid structure;anatomical tracing;Anxiety;Anxiety Disorders;Area;Binding;Brain;Clinic;Clinical;Communication;conditioned fear;Conditioned Stimulus;Coupling;Data;Dependence;Disease;emotion regulation;emotional behavior;Extinction;fear memory;Fostering;Freezing;Fright;Funding;Genetic;Goals;Hippocampus;Human;Impairment;Individual;innovation;Intervention;Label;Lead;Learning;learning extinction;Medial;Mediating;Memory;memory encoding;memory retrieval;Mental disorders;neural;neural circuit;Neurons;novel;optogenetics;Pathologic;Pathway interactions;Patients;pharmacologic;Phase;Post-Traumatic Stress Disorders;Prefrontal Cortex;prevent;Process;Rattus;Relapse;relapse prevention;Reporting;Retrieval;Reuniens Thalamic Nucleus;Role;Safety;System;Testing;Thalamic structure;Therapeutic Intervention;Trauma;Viral;Work

PROJECT_TITLE: Neural Substrates of Contextual Memory in Fear Extinction


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Data Science;Hematology;Infectious Diseases;Lung;Orphan Drug;Patient Safety;Pneumonia;Pneumonia and Influenza;Precision Medicine;Rare Diseases;Sepsis

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Supplement Proposal for the APS CCC  Project Narrative The APS Consortium seeks to understand the heterogeneity and underlying mechanisms of critical illness syndromes and recovery, in adults with ARDS, pneumonia, and/or sepsis, as well as the relationship and biological overlap among these syndromes, and this will be accomplished through a prospective, longitudinal observational study with common data and biospecimen collection of 4,000 hospitalized adults who have or are at risk of developing ARDS, pneumonia, and/or sepsis. Since inception, there has been an expansion from an intended 5 Clinical Centers comprised of ~18 total sites to 6 Clinical Centers comprised of 22 total sites, and a determination that the Consortium would support data capture, statistical plans, and analysis efforts for 7 individual scientific aims as well as other expansions which requires supplemental resources to facilitate rapid and broad sharing of data and biospecimens, a core function of the Consortium. The purpose of this administrative supplement is to enhance, expedite, and expand previously planned activities related to biospecimen and data sharing that are within the scope of the approved award but were unforeseen at the time of submission.

PI_NAMEs: BERNARD, GORDON RAPHAEL;LINDSELL, CHRISTOPHER J.;SELF, WESLEY H (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Adherence;Administrative Supplement;Adult;Attenuated;Award;Big Data;biobank;Biological;Biometry;career development;Caring;Classification;Clinical;clinical center;Clinical Research;Clinical Trials Data Monitoring Committees;Cognitive;cohort;Collection;Communication;Communities;community engagement;Compensation;Complex;Contracts;Critical Illness;Data;Data Collection;data infrastructure;data management;data quality;data sharing;Dedications;Development;efficacious treatment;electronic consent;Electronic Health Record;Ensure;experience;Failure;Foundations;Goals;Grouping;Heterogeneity;Hospitalization;Image;improved;Individual;individual patient;innovation;Investigation;Knowledge;knowledge base;Leadership;Longitudinal, observational study;Manuals;Measures;Monitor;Morbidity - disease rate;mortality;novel therapeutics;operation;Operations Research;Outcome;Participant;patient population;patient subsets;Patients;performance site;personalized management;Pharmacotherapy;Phenotype;phenotyping algorithm;Pneumonia;point of care;precision medicine;Precision therapeutics;Process;profiles in patients;prospective;protocol development;Protocols documentation;Recovery;recruit;Reporting;Reproducibility;Research;Research Design;Resources;Risk;Science;Security;Sepsis;Site;skill acquisition;Specimen;Statistical Data Interpretation;success;Syndrome;synergism;targeted treatment;Therapeutic;Time;Training;Training Support;Translating;treatment response;Trust;virtual

PROJECT_TITLE: Expediting the Sharing of APS Consortium Specimens and Data Amidst Expanded Operations


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE Plants express small RNAs that accumulate to high levels in reproductive organs harboring the male germline; these small RNAs show interesting parallels to the animal piRNAs, and perturbation of their biogenesis or activities causes sterility. Our proposed study aims to understand the localization, biogenesis, functions, and targets of a specialized class of the small RNAs (the 21-nt phased, small interfering RNAs) that are abundant prior to meiosis, using the maize as the model system. The research outcomes will provide mechanistic insights into the biogenesis and functions of these small RNAs, with the potential to illuminate why plants have evolved this unusual small RNA pathway enriched in or even specific to male reproduction.

PI_NAMEs: CZYMMEK, KIRK ;MEYERS, BLAKE C (contact);WALBOT, VIRGINIA E

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Angiosperms;Animals;Biochemical;Biogenesis;Biological Models;Biology;Cell Differentiation process;Cells;chromatin modification;Chromosomes;CRISPR/Cas technology;Data;Defect;Dependence;Development;Developmental Process;Distal;DNA Methylation;DNA Polymerase II;DNA Transposable Elements;Drosophila genus;Drug or chemical Tissue Distribution;Environment;Epidermis;Evolution;Exhibits;experimental study;Failure;Family;Fertility;Genetic;Genome;Genome Stability;genome-wide;Genomics;Germ Lines;Goals;gonad development;Grain;Image;Individual;insight;Maize;male;male fertility;Male Sterility;Mammals;Maps;Mediating;Meiosis;Messenger RNA;MicroRNAs;Minor;Modeling;Molecular;Movement;Mus;mutant;Mutation;Nature;Nematoda;novel;Organ;Oryza sativa;Outcomes Research;Paper;Pathway interactions;Phase;Phenotype;piRNA;Plant Model;Plants;pluripotency;Poaceae;Pollen;Production;Proteins;Reporting;Reproduction;reproductive;Reproductive Biology;reproductive development;reproductive organ;Research;Rice;RNA;RNA Precursors;Role;Signal Transduction;single-cell RNA sequencing;Small Interfering RNA;Small RNA;Somatic Cell;spatiotemporal;sperm cell;stem cells;Sterility;Techniques;Testis;Transcript;transcription factor;Untranslated RNA;Work;Zea mays

PROJECT_TITLE: The biogenesis and functions of pre-meiotic small RNAs in male reproductive development in maize

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cancer

ORG_CITY: FAYETTEVILLE

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: Tumor cells form various types of clusters along the metastatic cascade, including locally invaded tumor strands,  circulating tumor cell clusters, and micrometastases. Growing evidence suggests that tumor cell clusters exhibit  deleterious advantages over signal tumor cells in terms of invasion, survival, drug resistance, and colonization,  and may be the dominant form of tumor cells that leads to metastases. Hence, understanding how tumor cell  clustering gives rise to these collective advantages is of critical importance in countering cancer. Altered  metabolism is a hallmark of cancer and holds great potential as a therapeutic target. Recent reports suggest that  tumor clusters exhibit a distinct metabolic profile when compared to single tumor cells and that cell-cell binding  can alter cellular ATP production. Hence, we hypothesize that cell clustering may provide tumor clusters with  collective advantages by altering their bioenergetics. We will leverage our expertise in tissue and extracellularmatrix  engineering, metabolic imaging, and computational modeling to test this hypothesis. In Aim 1, we will  investigate how cell-cell interactions affect the bioenergetics of the tumor clusters. We will combine micropattern  and microfabrication to engineer tumor clusters of different sizes and shapes to precisely control the degree of  cell-cell adhesions and develop a physics model to combine the free energy of the cluster system with the active  cellular ATP energy. In Aim 2, we will investigate how cell-matrix interactions affect the bioenergetics of the  tumor cluster. We will engineer the mechanical properties, ligand types, ligand densities, and topography of the  matrix to study how these factors may affect the energy production of the cells in the cluster and the associated  metabolic signaling. In Aim 3, we will investigate how heterogeneous cell-cell interactions and metabolism affect  the bioenergetics and dynamics of the tumor clusters. We will leverage our expertise in sorting cells based on  metabolic or other phenotypes and control the degree of heterogeneous cell-cell interaction by controlling the  mixing ratio of the sorted cell subpopulations. We will further combine experiments and modeling to identify if  tumor clusters of a certain size, shape, and heterogeneity, and in a certain extracellular microenvironment will  become energetically unstable and thus more likely to invade or become less sensitive to perturbations thus  more likely to survive. Together, the proposed study will establish a systematic understanding of how different  aspects of cell clustering contribute to the bioenergetics of each cell in the cluster and the whole cluster, which  may then lead to their collective advantage. As therapeutics that are effective for single cells often fail for tumor  cell clusters, the successful completion of this project will lay the foundation for future studies that allow the  development of efficient cancer therapies to counter cancer as it relates to tumor cell clustering, micrometastases,  and metabolic adaptation.

PI_NAMEs: ZHANG, JIAN  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Affect;Arkansas;Binding;Bioenergetics;cancer therapy;Cell Communication;Cell Separation;Cell-Cell Adhesion;Cells;Cellular Metabolic Process;Computer Models;Development;Drug resistance;Engineering;Exhibits;experimental study;extracellular;Extracellular Matrix;Foundations;Free Energy;Future;Heterogeneity;Invaded;Ligands;Malignant Neoplasms;mechanical properties;Metabolic;metabolic imaging;metabolic profile;Metabolism;Microfabrication;Micrometastasis;Modeling;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Pattern;Phenotype;Physics;Production;Reporting;Research;Shapes;Signal Transduction;System;Testing;therapeutic target;therapeutically effective;Tissues;tumor

PROJECT_TITLE: Investigating the bioenergetics of tumor cell clustering and cell-cell interactions


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Pediatric;Prevention;Women's Health Research

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

ORG_STATE: MD

PI_NAMEs: DRIVER, BARBARA  (contact)

PROJECT_TERMS: Adolescent;adolescent woman;AIDS clinical trial group;AIDS prevention;Anti-Retroviral Agents;antiretroviral therapy;Area;Child;Childhood;clinical center;Clinical Protocols;Clinical Trials;Clinical Trials-Pediatric AIDS;co-infection;Collaborations;Communicable Diseases;Communities;comorbidity;Conduct Clinical Trials;Data;Data Analyses;data integration;Development;Diagnosis;Disease remission;Epidemic;Epidemiology;Formulation;Funding;Goals;Grant;HIV;HIV Infections;HIV therapy;HIV/AIDS;Individual;Infant;Infection;infection rate;Institution;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;Knowledge acquisition;Leadership;Light;Monitor;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;Nature;Opportunistic Infections;Passive Immunotherapy;patient population;perinatal HIV;Pharmaceutical Preparations;Population;Postpartum Women;Pregnant Women;prevent;Prevention;Prevention approach;Process;Protocols documentation;recruit;Reporting;Research;Research Personnel;Research Priority;Resources;Science;Site;Symptoms;synergism;targeted treatment;Testing;Therapeutic Agents;therapeutic vaccine;Time;transmission process;U-Series Cooperative Agreements;Vaccines;Vertical Disease Transmission;Work

PROJECT_TITLE: HIV AND OTHER IMPAACT RELATED INFECTIOUS DISEASE STUDIES


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Natural Products

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: PENDLETON, RICHARD  (contact)

PROJECT_TERMS: Area;Back;conditioning;Division of Cancer Treatment and Diagnosis;Mechanics;Molds;Natural Products;Phase;remediation;repository;System;Update;Walking

PROJECT_TITLE: FY232 FACILITIES TO G-B1073 MOLD REMEDIATION


ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project narrative The establishment of left-right (LR) asymmetry is a critical event required for the correct positioning of internal organs. Defects in human LR axis formation cause birth defects of the heart, vasculature, lungs, and intestinal tract. Our research aims to discover the central mechanism that links Hedgehog (Hh) signaling pathway and transforming growth factor-b (TGF-b) signaling pathway to the establishment of left-right asymmetry.

PI_NAMEs: ZHENG, XIAOYAN  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Affect;Biochemical;Cilia;Competence;Congenital Abnormality;Defect;Development;Developmental Biology;Diagnosis;disability;Drosophila genus;early embryonic stage;Embryo;Embryonic Development;Erinaceidae;Event;Extracellular Matrix Proteins;Fibronectins;fluid flow;Gene Expression;gene network;Generations;Genes;genetic approach;Growth;heart defect;homeodomain;Homologous Gene;Human;Intestines;Knowledge;Lateral;Left;Limb Bud;Link;Location;Lung;Mediating;Mesoderm;Molecular;Morphogenesis;Mus;Neural tube;neuron loss;Neurons;neurotrophic factor;Nodal;novel;Organ;Pathway interactions;Pattern;Play;Positioning Attribute;preventive intervention;Regulation;Research;response;Role;Rotation;secretory protein;Side;Signal Pathway;Signal Transduction;Site;smoothened signaling pathway;Source;Structure;Testing;TGF Beta Signaling Pathway;Therapeutic Intervention;tool;transcription factor;Transcriptional Regulation;Transforming Growth Factor beta;Transforming Growth Factors;Travel;vertebrate embryos;Vertebrates;Wing;Work

PROJECT_TITLE: Linking Hedgehog and Nodal/TGF-beta signaling in the establishment of left-right asymmetry

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Colorectal cancer (CRC) is the 3rd most common cancer and 2nd leading cause of death in men and women combined, and colitis-associated cancer (CAC) is a subset. Multiple studies have suggested a link between CRC and bacterial factors or inflammation, and the link between inflammatory bowel disease (IBD) and colonic pre-cancerous lesions and cancer itself is firmly established. The cumulative probability of developing cancer in ulcerative colitis depends greatly on disease duration, and is 2% by 10 years, 8% by 20 years, and 18% by 30 years. The prevalence of IBD is increasing among VA healthcare system users. Veterans with IBD develop CRC at a younger age and are more likely to develop right-sided colon cancer. CRC, including CAC, represents a significant health problem for our Veterans. Therefore, there is an ongoing need to discover new approaches for improving patient risk stratification and/or novel treatment strategies; we aim to establish CCL11 as an important target.

PI_NAMEs: COBURN, LORI A (contact)

PROJECT_TERMS: Acute;Adult;Affect;Age;American;Animals;Antibodies;APC gene;Apoptosis;Azoxymethane;Behavior;Cancer Model;carcinogenesis;carcinogenicity;Cause of Death;Cell Physiology;Cells;Chemotactic Factors;Clinical;cohort;Colitis;colitis associated cancer;Colitis associated colorectal cancer;Colon;colon cancer cell line;Colon Carcinoma;Colorectal Cancer;Crohn's disease;cytokine;Data;Development;dextran sulfate sodium induced colitis;disorder control;DNA Damage;DNA Sequence Alteration;eosinophil;Eotaxin;Epithelial Cells;epithelial wound;Epithelium;Exhibits;Exposure to;Functional disorder;Future;Gene Expression Profile;Genetic;HCT116 Cells;Health;Healthcare Systems;Histologic;Human;illness length;Immune response;improved;Infiltration;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;insight;knock-down;Lesion;Link;Malignant Neoplasms;MAP Kinase Gene;Mediating;men;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenic;Organoids;Patient risk;Patients;Phenotype;premalignant;Prevalence;Probability;prospective;receptor;Recombinants;Reporting;risk stratification;Role;Sampling;Serum;Severity of illness;Side;Signal Pathway;Signal Transduction;Sodium Dextran Sulfate;Somatic Mutation;Testing;Tissues;treatment strategy;tumor;Tumor Burden;Tumor Promotion;tumorigenesis;Ulcerative Colitis;Veterans;Woman

PROJECT_TITLE: The Role of CCL11 in Inflammatory and Sporadic Colorectal Cancer.


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: SEATTLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Stabilized HIV-1 envelope trimer vaccines such as BG505 SOSIP elicit strong neutralizing antibody responses that protect against the matched virus in nonhuman primates. Here, we will understand how these neutralizing antibodies are elicited and acquire breadth in some instances, and how this compares to humans immunized with same vaccine along with multiple adjuvants.

PI_NAMEs: DERDEYN, CYNTHIA ANN (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Address;Adjuvant;Alleles;Animals;Antibodies;Antibody Response;Antibody Specificity;Antibody titer measurement;antigen binding;Antigens;Attention;Autologous;B-Lymphocytes;Binding;Binding Sites;biophysical properties;Biophysics;CD4 Antigens;Characteristics;Clinical;clinically significant;Cryoelectron Microscopy;Cryopreservation;Cyclic GMP;Databases;Dependence;Development;Epitopes;Exhibits;Formulation;Germ Lines;glycosylation;HIV;HIV Envelope Protein gp120;HIV Vaccine Trials Network;HIV-1;Human;human subject;Human Volunteers;Immunization;Immunize;Immunoglobulin G;Immunoglobulins;improved;Individual;Macaca mulatta;Maps;Modeling;multidisciplinary;mutant;neutralizing antibody;neutralizing monoclonal antibodies;non-Native;nonhuman primate;novel;Participant;Pathway interactions;Phase I Clinical Trials;Plasma;Polysaccharides;pre-clinical;preclinical study;Production;Resources;Retrospective Studies;Sampling;Serum;simian human immunodeficiency virus;Site;Structure;Surface Plasmon Resonance;Testing;Vaccination;vaccination strategy;Vaccines;Variant;Viral;Virus;X-Ray Crystallography

PROJECT_TITLE: Tracking the evolutionary trajectory of neutralizing antibodies following BG505 SOSIP immunization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-T(90)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE We have demonstrated that the unfolded protein response (UPR) pathway in the mold pathogen Aspergillus fumigatus is essential for establishing infection in a mouse model of fungal keratitis. We will test the feasibility of targeting this pathway for treatment by (1) repressing the expression of UPR genes with an exogenous repressor (genetics) and, (2) employing existing pharmacological compounds that target a key UPR protein (drug repurposing). Will also identify downstream UPR targets that may also be important for virulence and, accordingly, represent targets for novel antifungal development.

PI_NAMEs: FULLER, KEVIN K. (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Animals;anti-fungal agents;Anti-Inflammatory Agents;Antigen Presentation;Aspergillus fumigatus;Attenuated;Automobile Driving;Biomass;Blindness;Catabolism;Cell Wall;Cell Wall Alteration;Cells;chromatin immunoprecipitation;Clinical;clinically relevant;Collagen;collagenase;Cornea;Corneal Diseases;Corneal Stroma;cytokine;Defect;Development;Disease;Disease Progression;DNA Microarray Chip;Doxycycline;drug repurposing;Drug Targeting;Endoplasmic Reticulum;Environment;Enzymes;Exhibits;feasibility testing;Flow Cytometry;follow-up;Fungal Antigens;Fungal Proteins;fungus;Future;Genes;Genetic;genome-wide;Glucose;Golgi Apparatus;Growth;Harvest;Histopathology;Hypersensitivity;Hyphae;improved;In Vitro;in vitro activity;in vivo;Incubated;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;insight;interest;Investigation;Keratitis;Keratoplasty;knock-down;Leucocytic infiltrate;Macrophage;melting;Membrane;microbial;misfolded protein;Modeling;Molds;Monitor;Morbidity - disease rate;mouse model;Mus;mutant;neutrophil;new therapeutic target;next generation sequencing;NF-kappa B;novel;Nutrient;Operative Surgical Procedures;Orthologous Gene;Outcome;pathogen;Pathway interactions;Peptide Hydrolases;Perforation;Persons;Pharmaceutical Preparations;pharmacologic;Physiological;Play;Proliferating;promoter;protein folding;Protein Secretion;Proteins;receptor;Repression;Research Priority;Resolution;response;RNA;Role;Sampling;Severity of illness;Signal Transduction;Site;Source;Strategic Planning;Stress;Structure;targeted treatment;Testing;Tetracyclines;therapeutic target;Topical application;transcription factor;transcriptome sequencing;uptake;Virulence;Virulence Factors;Visual;Work

PROJECT_TITLE: The unfolded protein response as a therapeutic target for fungal keratitis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Burden of Illness;Cardiovascular;Clinical Research;Contraception/Reproduction;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Hypertension;Infant Mortality;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CHARLESTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The global COVID-19 pandemic caused by SARS-CoV-2 has highlighted the extent to which social determinants and inequities impact healthcare received and health outcomes. This project will evaluate maternal and infant effects following the COVID-19 pandemic and SARS-CoV-2 infection during pregnancy including pregnancy complications, adverse birth outcomes, maternal and infant mortality, and maternal one-year post pregnancy cardiovascular and mortality outcomes with a focus on social determinants of health and racial/ethnic differences. Better understanding of the impact of the COVID-19 pandemic and SARS-CoV-2 infection during pregnancy on maternal and infant morbidity and mortality is needed to guide clinical practice and public health prevention efforts for at-risk populations.

PI_NAMEs: HUNT, KELLY J;MALEK, ANGELA M (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: 2019-nCoV;Admission activity;adverse birth outcomes;African American;Birth;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Caring;Censuses;Clinic;clinical care;clinical practice;comorbidity;Coronary heart disease;coronavirus pandemic;COVID-19;COVID-19 diagnosis;COVID-19 incidence;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 prevalence;COVID-19 test;Data;Data Set;Death Rate;Diabetes Mellitus;Disparity;Economics;Embolism;Emergency department visit;ethnic difference;ethnic disparity;Ethnic Origin;Event;Extracorporeal Membrane Oxygenation;follow-up;Functional disorder;Health;health care availability;health care service;health difference;health disparity;health inequalities;Health Policy;Healthcare;Hispanic;Hospitalization;human old age (65+);Hypertension;improved;indexing;Infant;infant morbidity;infant morbidity/mortality;Infant Mortality;infant outcome;Infection;Intensive Care Units;Interruption;Job loss;Left;Link;Live Birth;Longitudinal cohort;maternal diabetes;maternal morbidity;Maternal Mortality;maternal obesity;maternal outcome;maternal risk;Measures;Mechanical ventilation;Medicaid;Medical;Minority Groups;Morbidity - disease rate;mortality;Mothers;Myocardial Infarction;novel;Obesity;Outcome;outcome disparities;pandemic coronavirus;pandemic disease;Population;population based;Population Study;Populations at Risk;post pregnancy;Pre-Eclampsia;pre-pandemic;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;prepregnancy;prepregnancy obesity;Prevention;Public Health;Race;racial difference;racial disparity;Records;Reporting;Risk;Risk Factors;SARS-CoV-2 infection;SARS-CoV-2 positive;severe maternal morbidity;Small for Gestational Age Infant;social;social determinants;social disparities;Social Distance;social health determinants;social vulnerability;Social Work;South Carolina;Stroke;Testing;Time Series Analysis;Transportation;United States;Vascular Diseases;ventilation;Ventricular;Woman;Women's cohort;Women's Health

PROJECT_TITLE: Impact of the COVID-19 pandemic, SARS-CoV-2 infection and social determinants of health on pregnancy complications, birth outcomes and post-pregnancy maternal cardiovascular and mortality outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative: Type 2 diabetes is a costly disease that is more prevalent in Latino families. This study will test the effects of a diabetes prevention program for Latino families who are at risk for diabetes. We will also look for ways to expand diabetes prevention programs across multiple communities through partnerships.

PI_NAMEs: SHAIBI, GABRIEL QUANTUM (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: access disparities;Address;Adolescent;Adopted;Adult;Area;Arizona;Biological;Body Composition;Child;cohesion;Collaborations;Communities;community organizations;community partners;comparison control;Complex;cost;Cost of Illness;cultural values;Data;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;diabetes risk;Diffusion;Disease;Effectiveness;efficacy testing;empowerment;Evidence based intervention;experience;Exploration, Preparation, Implementation, and Sustainment;Family;Family health status;Family Process;family structure;Funding;glucose tolerance;Glycosylated hemoglobin A;Goals;Health;Health behavior;Health behavior and outcomes;health equity;Health Services Accessibility;high risk;hybrid type 1 design;improved;Individual;Intervention;Latino;Latino Population;learning community;life span;lifestyle intervention;lifetime risk;Link;low health literacy;Mediator;Methods;minority communities;Modeling;Morbidity - disease rate;National Institute of Diabetes and Digestive and Kidney Diseases;neighborhood disadvantage;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Obesity;Outcome;outcome disparities;Parents;peer;Population;Positioning Attribute;Prediabetes syndrome;Predisposition;Premature Mortality;Prevalence;prevent;Prevention;Prevention trial;preventive intervention;psychosocial;Quality of life;Readiness;Research Personnel;resilience;Risk Factors;Series;social;social determinants;System;Testing;Time;Translating;Underserved Population;United States National Institutes of Health;vulnerable community;Vulnerable Populations;Youth

PROJECT_TITLE: Preventing Diabetes in Latino Families

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: Project Narrative The proposed R01, Improving Medication Adherence with Pharmacist and Community Health Worker Team (IMPaCT) to Reduce Disparities in Hypertension, will test the effectiveness of an innovative, culturally-tailored, coordinated care intervention derived from previous research (RxHL Study, 1R01HL120907) and existing pilot medication therapy management program at the research site. Building on an ecosocial framework of chronic disease self-management, the IMPaCT intervention by pharmacist-community health worker team will identify and address individual, clinical, social-cultural and structural barriers to medication adherence among low- income minority patients with hypertension, polypharmacy use and nonadherence. To determine effectiveness, we will conduct a rigorous, intention-to-treat randomized controlled trial among African-American, Latino and Vietnamese patients at a community health center to create a practical solution to the adherence problem and provide a how-to framework for healthcare workforce to reduce health disparities in hypertension and prevent cardiovascular risks among the vulnerable population.

PI_NAMEs: LEE, JEANNIE KIM (contact);SHAW, SUSAN J

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: accountable care organization;Address;Adherence;adherence rate;adverse outcome;African American;Automobile Driving;Belief;Blood Pressure;blood pressure control;Body mass index;burden of chronic illness;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;care coordination;care providers;Caring;caucasian American;Cessation of life;Chronic Disease;Clinical;Clinical Pharmacists;clinical practice;Communities;Community Health Aides;comorbidity;cost;culturally appropriate intervention;Data Collection;Death Rate;design;Diagnosis;Disparity;disparity reduction;Distal;Dose;Education;Effectiveness;effectiveness evaluation;effectiveness testing;Electronic Health Record;ethnic disparity;ethnic minority;Ethnic Population;experience;Face;food insecurity;Fright;Glycosylated hemoglobin A;Health;Health behavior;Health Insurance;health literacy;Health Services Accessibility;Healthcare;Heart Diseases;high risk;high risk population;Hypertension;Immigrant;improved;Individual;innovation;Insurance Coverage;Intention;Intervention;Kidney Diseases;Latino;Linguistics;low health literacy;Low income;Low Income Population;Low-Density Lipoproteins;mathematical ability;Measures;medication compliance;Medication Management;Medicine;member;minority patient;Modeling;neglect;Neighborhood Health Center;Outcome;Participant;patient navigator;patient oriented;Patient Self-Report;Patients;Pharmaceutical Preparations;Pharmacists;pill;Play;Polypharmacy;Population Heterogeneity;post intervention;Poverty;premature;prevent;Primary Care;primary care provider;programs;Qualifying;racial disparity;racial minority;racial minority population;racial population;Randomized;Randomized, Controlled Trials;Reduce health disparities;Regimen;Reporting;Research;Research Personnel;Research Project Grants;Resources;response;Risk Factors;Role;Self Management;Services;Site;skills;social;social culture;Social Environment;Social support;Stroke;Surveys;theories;Transportation;Vietnamese;Vulnerable Populations;Waiting Lists;Work

PROJECT_TITLE: Pharmacist-CHW Team to Improve Medication Adherence and Reduce Hypertension Disparities

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: LAS VEGAS

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: Project Narrative All life forms require their genetic material to be organized and packaged into cells, but this genetic sequestration often silences gene expression. Here, the mechanism that relieves the silencing of virulence genes in the bacterial pathogen Shigella, will be studied by undergraduates and graduate students at the University of Nevada Las Vegas. The primary focus of these studies will be a newly identified ligand of the key anti-silencing protein, VirB.

PI_NAMEs: WING, HELEN J (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Alanine;Bacteria;Bacterial Physiology;Binding;Binding Proteins;Biochemical;Biological Assay;Body Temperature;Cells;Complex;Data;dimer;Distant;DNA;DNA Binding;DNA-Binding Proteins;Elements;Exhibits;experimental study;Gene Expression;Gene Silencing;Genes;Genetic;genetic approach;Genetic Materials;Genetic Screening;Genetic Transcription;Goals;graduate student;Histones;Human body;human disease;Hydrolysis;in vitro Assay;innovation;insight;Life;Ligands;Link;Literature;Measures;Mediating;member;Modeling;Molecular Conformation;mutant;Nevada;novel;nucleoside triphosphate;pathogenic bacteria;Phenotype;plasmid DNA;Plasmids;Play;Positioning Attribute;Process;promoter;Proteins;Publishing;Role;segregation;Shigella;Shigella flexneri;Site;Structure;Superhelical DNA;Temperature;Testing;Transcriptional Regulation;undergraduate student;United States National Institutes of Health;Universities;Virulence;virulence gene;Work

PROJECT_TITLE: Understanding transcriptional silencing & anti-silencing mechanisms in Shigella

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-L(80)A]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE This K08 career development award proposal describes the training and skills that the PI, Dr. Jennifer Leonard, will require over the next 4 years to become an independent physician-scientist. The goal of the research is to understand the role of the innate immune system in trauma induced acute lung injury and susceptibility to secondary infections. Collectively, the proposed experiments will provide key insights for a current gap in knowledge about the mechanism of lung injury after trauma and identify novel targets for treatment and prevention.

PI_NAMEs: LEONARD, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: Acute Lung Injury;Address;Adoptive Transfer;Anti-Infective Agents;Antibodies;antimicrobial;Bacteria;Bacterial Pneumonia;Biological;Biological Assay;Bronchoalveolar Lavage;CD28 gene;CD3 Antigens;Chemicals;clinical translation;Complication;CSF3 gene;cytokine;Cytoplasmic Granules;cytotoxic;Data;defined contribution;Development;DNA;Enzyme-Linked Immunosorbent Assay;Enzymes;experimental study;extracellular;FDA approved;Flow Cytometry;Generations;Genetic;Goals;Histone H3;Hospitalization;Host Defense;Immobilization;Immune response;Immune System Diseases;immunocytochemistry;Immunologics;Immunophenotyping;improved;improved outcome;Infection;Inflammation;Inflammatory Response;inhibitor;injured;Injury;Innate Immune System;Inpatients;insight;Interferon Type II;Internet;intravital microscopy;Invaded;K-Series Research Career Programs;Knowledge;Laboratories;leukocyte activation;Leukocytes;lung injury;Lymphocyte;Lymphocyte Function;Measures;Mediating;monocyte;mouse model;Multiple Trauma;Mus;neutrophil;Nosocomial pneumonia;novel;pathogen;Pathway interactions;Patient-Focused Outcomes;Patients;peripheral blood;pharmacologic;Physicians;Plasma;Pneumonia;post-trauma;Predisposition;prevent;Prevention;Production;Protocols documentation;Pseudomonas;Pseudomonas aeruginosa;Pseudomonas aeruginosa pneumonia;Research;Respiratory Tract Infections;response;Risk;Role;Scientist;secondary infection;Secondary to;Sepsis;Serum;severe injury;Signal Transduction;skills;Splenocyte;Stains;Sterility;systemic inflammatory response;Technology;Testing;Therapeutic;therapy development;time interval;tissue injury;Tissues;TNF gene;tool;Training;Translating;Trauma;Trauma patient;Traumatic injury;Up-Regulation;Visualization

PROJECT_TITLE: Netosis in Trauma Mediated Acute Lung Injury

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: Aurora

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative This application herein describes a new T32 Training Program at the University of Colorado entitled “Interdisciplinary Training in Musculoskeletal Research” requesting support for 4 predoctoral and 2 postdoctoral trainees. The overarching mission of the Program is to provide comprehensive interdisciplinary training in musculoskeletal science with the aim of developing the next generation of outstanding musculoskeletal investigators.

PI_NAMEs: PAYNE, KARIN A;ZUSCIK, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Musculoskeletal;Research;Training


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Data Science;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Machine Learning and Artificial Intelligence;Maternal Health;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Nutrition;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE This K99 Career Development Award seeks to provide the applicant training in prenatal psychosocial stress and iron assessment, advanced biostatistics focused on machine learning, placental mechanisms of fetal programming, and research with socioeconomically-, ethnically-, and racially minoritized pregnant populations to support the applicant’s transition to research independence. Through the training embedded in this award, the applicant will develop the skills and expertise necessary to build a translational research program within a Developmental Origins of Health and Disease (DOHaD) framework that will examine pathways by which early exposure to psychosocial stress becomes biologically embedded to affect mother and offspring’s mental and physical health. This approach will ultimately identify mechanisms, markers, and modifiable risk factors relevant to maternal health and child development outcomes.

PI_NAMEs: REID, BRIE M (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: absorption;adverse pregnancy outcome;Affect;Anemia;Animals;Award;Behavioral;Bioinformatics;Biological;biological adaptation to stress;Biometry;Birth;Blood specimen;Blood Volume;C-reactive protein;Child Development;Chronic;Chronic stress;cohort;cytokine;Data;Data Set;Decidua Basalis;Development;Diagnosis;Disease;DNA Methylation;early life stress;Endowment;ethnic minority;Ethnic Minority Women;experience;Exposure to;Ferritin;fetal;fetal programming;Funding;Generations;Goals;Health;Hematocrit procedure;Hemoglobin;hepcidin;high risk;Hydrocortisone;Hypothalamic structure;infancy;Infant;Infant Health;Inflammation;Inflammatory;inflammatory marker;insight;Intake;Interleukin-6;Intervention;Iron;iron absorption;Iron deficiency anemia;iron supplement;K-Series Research Career Programs;Life;Low income;Machine Learning;machine learning method;Maternal and Child Health;Maternal Health;maternal risk;maternal stress;mean corpuscular volume observed;Measures;Mediating;Medical Records;Mental Health;MicroRNAs;modifiable risk;Mothers;mRNA Expression;multidimensional data;Neonatal;neonate;neurodevelopment;Neurosecretory Systems;nutrient metabolism;offspring;Oral;Outcome;Pathway interactions;Patient Self-Report;Phase;Phenotype;physical conditioning;Pituitary Gland;Placenta;Play;Population;pre-clinical;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal stress;Process;prospective;Psychological Stress;Psychophysiology;Psychosocial Stress;Race;racial minority;racial minority women;recruit;Regulation;Research;Risk;Risk Assessment;Risk Factors;Role;Shapes;Signal Transduction;skills;socioeconomics;Statistical Methods;Stress;Stressful Event;supervised learning;Supplementation;systemic inflammatory response;Techniques;Testing;Third Pregnancy Trimester;Time;Training;translational research program;Umbilical Cord Blood;Vitamins;Woman;Work

PROJECT_TITLE: Machine learning methods to assess risk for prenatal and neonatal iron deficiency anemia from maternal stress exposure


ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Obesity and its associated metabolic disorders represent a major threat to the American health, as well as a substantial economic burden. Thermogenic fat is a specialized tissue whose role is to expend excess energy, and activating this tissue might ameliorate metabolic disease in humans. This proposal aims to understand how this cell type is naturally regulated in order to identify new ways to therapeutically activate it.

PI_NAMEs: DUMESIC, PHILLIP ANTHONY (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: 3' Untranslated Regions;adipocyte biology;adipocyte differentiation;Adipocytes;Adrenergic Agents;Affect;Affinity Chromatography;American;Area;Attention;Award;Basic Science;Biogenesis;Bioinformatics;Biotinylation;Case Study;Cell Respiration;cell type;Chemicals;cis acting element;Cytoplasm;Cytoplasmic Granules;Dana-Farber Cancer Institute;Data;Data Set;design;Diabetes Mellitus;Disease;Economic Burden;Elements;Energy Metabolism;Environment;experimental study;Fatty acid glycerol esters;Follow-Up Studies;Functional disorder;Gene Expression;genetic manipulation;Genetic Transcription;Goals;Health;helicase;Homeostasis;hormone regulation;Hormones;Human;In Vitro;in vivo;insight;Instruction;knock-down;Lead;Leadership;Mass Spectrum Analysis;medical schools;Mentors;Mentorship;Messenger RNA;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Methods;Mitochondria;Molecular;mouse model;mRNA Translation;Mus;Mutation;Norepinephrine;novel;Obesity;obesity treatment;Output;Oxidative Phosphorylation;Pathway interactions;pharmacologic;Phase;Phenotype;Physiological;Physiology;Play;Post-Transcriptional Regulation;posttranscriptional;preference;Prevalence;prevent;Process;programs;Property;protein purification;Proteomics;Regulation;Research;ribosome profiling;Ribosomes;RNA;RNA-Binding Proteins;Rodent Model;Role;Signal Transduction;skills;stem;stress granule;System;Technology;Testing;Therapeutic;Thermogenesis;Tissues;Training;transcriptomics;translation factor;translational impact;Translational Regulation;Translational Repression;Translations;uncoupling protein 1;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Translational regulation of PGC1alpha and oxidative metabolism


ORG_CITY: NEW YORK

ORG_NAME: YESHIVA UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative A clinical gap exists for patients with KRAS mutated CRC with fewer treatment options and lack of appropriate responsiveness to newly emerging immune therapy. We will explore the immune stimulation characteristics of reovirus and further follow the contribution of autophagic pathway in the process. Results will provide valuable insight that can be utilized to strategize an effective immune therapy for immune deserted KRAS mutated CRC patients.

PI_NAMEs: MAITRA, RADHASHREE  (contact)

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: Address;Administrative Supplement;Adopted;Autophagocytosis;Characteristics;Clinic;Clinical;colon cancer cell line;colon cancer patients;Colorectal Cancer;Colorectal Neoplasms;Development;Double-Stranded RNA;Environment;Event;Genome;Immune;Immunologic Stimulation;Immunotherapy;improved;insight;Knowledge;KRAS oncogenesis;KRAS2 gene;Malignant Neoplasms;Mediating;Molecular;mouse model;mutant;Mutate;neoplastic cell;Oncolytic;Pathway interactions;Patients;Pattern;Process;Property;Recommendation;Reovirus;Research;Research Support;Science;success;Tamoxifen;Therapeutic;Transgenic Organisms;Translating;Treatment Efficacy;tumor;tumor microenvironment;undergraduate student

PROJECT_TITLE: Administrative Supplement: Autophagy mediated immune stimulation by reovirus in KRAS mutated colorectal cancer


ADMINISTERING_IC: AT

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Innate immunity is encoded in germline, yet on population level it is sufficient to recognize any pathogen even in absence of adaptive immunity. Exactly how new recognition specificities arise in innate immune receptors remain unknown. This project will address this fundamental gap and develop experimental and computational approaches to understand the evolution of innate immunity.

PI_NAMEs: KRASILEVA, KSENIA V (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: adaptive immunity;Adopted;Binding;Biodiversity;Cells;comparative genomics;Data;Evolution;fungus;Generations;Genome;Genomics;Germ Lines;Health;Immune system;Immunity;Immunologic Receptors;Innate Immune System;Ligands;Modeling;Natural Immunity;Organism;pathogen;Pattern;Plant Model;Population;Protein Family;Recurrence;Source;Specificity;Tertiary Protein Structure;Testing

PROJECT_TITLE: Cross-kingdom health: evolution of innate immune receptors and their targets


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Virus-host interaction studies in the context of chronic hepatitis B virus (HBV) have the potential to reveal novel targets for curative strategies. This application will focus on the impact of HBV genotypes and pre-core mutants on chronic HBV infection, sensitivity to antivirals, and hepatocyte responses using physiologically-relevant in vitro and in vivo models, robust multi-omics methods, and innovative genetic tools. Further evaluation of host factors and cellular pathways may be exploited for developing novel antiviral strategies towards a functional HBV cure.

PI_NAMEs: MICHAILIDIS, ELEFTHERIOS  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Address;Affect;Aftercare;Animal Model;Anti-viral Agents;Anti-viral Response;Antisense Oligonucleotides;Biology;Capsid;Cell Culture System;Cell Culture Techniques;Cells;Cessation of life;Chronic;Chronic Hepatitis B;chronic infection;Circular DNA;Classification;Clinical;Clinical Data;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;CRISPR/Cas technology;curative treatments;cytokine;Dependence;Disease Progression;e Antigens;Evaluation;Future;gene editing technology;Genetic;Genetic Transcription;Genotype;global health;Goals;HBV Genotype;Health;Hepatitis B Infection;Hepatitis B Virus;Hepatocyte;high risk;Human;humanized mouse;immune activation;Immune response;Immune system;Immune Targeting;In Vitro;in vivo Model;Individual;innate immune pathways;innovation;insight;Integration Host Factors;Interferon alpha;Knowledge;Life;Link;Liver;Liver Cirrhosis;Maintenance;Messenger RNA;Methods;Modeling;Molecular;mouse model;multiple omics;Mus;mutant;Mutation;Natural Immunity;novel;novel strategies;Nuclear;Nucleic Acids;nucleoside analog;Outcome;Outcomes Research;Pathogenesis;Pathway interactions;Patients;Pattern recognition receptor;Persons;Physiological;prevent;Primary carcinoma of the liver cells;Primary Cell Cultures;prophylactic;Proteomics;Research;response;Risk;Role;Serology;Severities;single cell analysis;System;Systems Biology;Techniques;Therapeutic Intervention;tool;transcriptomics;treatment effect;Treatment outcome;treatment response;Vaccines;Validation;Variant;Viral;Viral Genome;Viral Pathogenesis;viral rebound;Virus;Virus Diseases;virus host interaction;Virus Replication;Withholding Treatment

PROJECT_TITLE: Virus-host interactions for a cure against HBV

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Immunization;Immunotherapy;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative Chronic infection by hepatitis B virus is a leading cause of liver cirrhosis and cancer. This study will study the HBV vaccine antigens to improve their ability to elicit potent antibody and T cell responses in vaccination and immunotherapy.

PI_NAMEs: LAW, MANSUN  (contact)

PROJECT_TERMS: Accounting;analog;Animals;Anti-viral Agents;Antibodies;Antibody Response;antigen processing;Antigens;antiviral immunity;biological adaptation to stress;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Nucleus;Cells;Cessation of life;Chronic Hepatitis B;chronic infection;Circulation;Cirrhosis;Clinical Data;Communicable Diseases;cost;Country;COVID-19;Development;DNA;Drug Combinations;Drug Targeting;ds-DNA;efficacy testing;endoplasmic reticulum stress;Engineering;fighting;Formulation;Generations;Genes;Genetic Transcription;Glass;Hepatitis B;Hepatitis B Therapy;Hepatitis B Vaccines;Hepatitis B Virus;Hepatocyte;human disease;human pathogen;Immune;Immune response;Immune Tolerance;Immunization;immunogenic;Immunotherapy;improved;Infection;Investigation;Licensing;Life Cycle Stages;Liver Cirrhosis;Liver diseases;Malignant neoplasm of liver;Mammalian Cell;manufacturing process;Membrane Proteins;Messenger RNA;Modeling;mouse model;mRNA immunotherapy;Mutation;neutralizing antibody;nonhuman primate;novel;Open Reading Frames;overexpression;Patients;Persons;Pharmacotherapy;Prevention;Primary carcinoma of the liver cells;Process;Production;Prophylactic treatment;Proteins;proteostasis;Public Health;Recombinants;Regimen;response;RNA vaccine;screening;Signal Transduction;success;Surface Antigens;System;T cell response;T-Lymphocyte;Technology;therapeutic vaccine;tool;Transfection;Vaccination;vaccination outcome;Vaccine Antigen;vaccine candidate;vaccine development;vaccine efficacy;Vaccines;Viral;Viral Antigens;viral DNA;Viral Genes;Viral Vaccines;Virus;Virus Diseases;Virus Replication;Yeasts

PROJECT_TITLE: Novel Hepatitis B Vaccine and Immunotherapy

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE This two-phase “health equity acceleration” U01 application is submitted to participate in the FDA OMHHE Health Equity Innovation Award for “Racial & Ethnic Minority Acceleration Consortium for Health Equity (REACH) (U01)” focused on advancing “minority health and health equity focused research, outreach, and communications as well as support training and mentoring of diverse HBCU advanced students, fellows, and researchers.” Two pilot projects/programs submitted in this application will be developed under Phase 1, and subsequently implemented under Phase 2: a) A Pilot curriculum on “Regulatory Issues and Health Equity” and potential FDA OMHHE rotations for advanced students and faculty in HBCUs in Pharmacy (XULA College of Pharmacy) and Nursing (Helene Fuld School of Nursing CSU); and b) A Pilot research project which will move the discussion beyond barrier identification to develop strategies to address barriers to clinical trial diversity, in order to increase trustworthiness, enhance transparency in sponsors and researchers, and bolster willingness to participate for African Americans, thereby strengthening equity in participation of underrepresented minority racial and ethnic groups in clinical trials.

PI_NAMEs: BAQUET, CLAUDIA R0SE (contact)

PROGRAM_OFFICER_NAME: LEE, CHRISTINE

PROJECT_TITLE: Racial and Ethnic Minority Acceleration for Health Equity Consortium U01


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Microbiome;Nutrition

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE The gases present in flatus are an untapped source for valuable information about gut microbial metabolism. Here, we propose to develop a Smart Underwear device to directly measure the malodorous signaling molecule hydrogen sulfide from human flatus. This research could enable rational modulation of gut microbial hydrogen sulfide production through precision nutrition strategies.

PI_NAMEs: GHODSSI, REZA ;HALL, ANDREW BRANTLEY (contact);MUELLER, NOEL T

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TITLE: Employing smart underwear to measure gut microbial hydrogen sulfide production


ORG_CITY: ALBUQUERQUE

ORG_NAME: AMERICANS FOR INDIAN OPPORTUNITY

ORG_STATE: NM

PHR: Project Narrative Three sentences   With a collaborative approach grounded in Indigenous core cultural values, the Indigenous Innovators Collaborative (IIC) team will engage in community-based participatory research study to address the FDA priorities as outlined in FDA OMHHE Health Equity Innovation Award: Racial and Ethnic Minority Acceleration Consortium for Health Equity (REACH) funding opportunity. The IIC seeks to engage American Indian and Alaska Native (AIAN) communities, stakeholders, researchers in an exploration of clinical trials and promote cultural knowledge in understanding clinical trials in Indian Country. One of the fundamental goals of this study is to aid in identifying perceptions of clinical trials and gene therapy within the Native American population.

PI_NAMEs: KIPP, BILLIE ;PARKER, MYRA ELIZABETH;POSTON, STEPHINE  (contact)

PROJECT_TITLE: Racial & Ethnic minority Acceleration Consortium for Health Equity (REACH) Response from Indigenous Innovators Collaborative


NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Infertility;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

PHR: PROJECT NARRATIVE Regulation of the ovarian reserve in mammals has been mostly focused on germ cell development; however, other ovarian elements, such as extracellular matrix, are poorly understood. Loss of homeostasis of the extracellular matrices during adulthood is associated with fibrosis, inflammation, and premature ovarian aging. This project has an overall goal of understanding the mechanisms by which the extracellular matrices regulate the establishment of the ovarian reserve during development and how their maintenance can protect the ovary from aging.

PI_NAMEs: BRIENO-ENRIQUEZ, MIGUEL ANGEL  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: 4-methylumbelliferone;Acids;Adhesions;Adult;advanced maternal age;Age;Anti-Inflammatory Agents;Architecture;Binding;cell motility;Cell Proliferation;cell type;Cells;Companions;Cytoplasmic Tail;Cytoprotection;Deterioration;Development;drug development;Elements;Embryonic Development;Engineering;Environment;evidence base;Exons;extracellular;Extracellular Matrix;Female;fetal;Fibrosis;Genes;Germ Cells;Glycosaminoglycans;Goals;granulosa cell;HAS2 gene;Heterocephalus;Homeostasis;Human;Hyaluronan;hyaluronan synthase 1;Hydration status;in utero;in vivo;Inflammation;Inflammatory;inhibitor;innovation;life span;Link;Longevity;Maintenance;Mammals;Modeling;Mole Rats;Molecular Weight;mouse model;Mouse Strains;Mus;novel therapeutics;Oocytes;Organ;Outcome;Ovarian;Ovarian aging;ovarian reserve;Ovary;Perinatal;Phenotype;Population;postnatal;postnatal development;premature;Premature Ovarian Failure;Production;Proliferating;promoter;Property;Proteins;Publications;Regulation;Rejuvenation;reproductive function;reproductive longevity;Reproductive Periods;reproductive senescence;Research;Resistance;Rodent;Role;self-renewal;Series;Serine;Site;Somatic Cell;stem cell proliferation;stem cell survival;stemness;Structure of primordial sex cell;Testing;Tissues;Undifferentiated;Water;Woman

PROJECT_TITLE: Elucidating the role of the hyaluronan matrices on the establishment of ovarian reserve and aging

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PHR: PROJECT NARRATIVE In the 21st century, the emergence of novel influenza viruses, the emergence and re-emergence of numerous arboviruses, and the devastating COVID-19 pandemic have illustrated the requirement for strategies that allow for the rapid screening and deployment of vaccines. We have developed a “designer nanoparticle” platform, or nanophages, that can be rapidly and rigorously modified to screen and evaluate potential vaccine candidates that simultaneously display multiple antigenic biomolecules. We propose to develop second generation tools and technologies for rapid screening and formulation of vaccine candidates, herein for current and emerging SARS coronaviruses, but that can be applied to virtually any pathogenic target.

PI_NAMEs: CATALANO, CARLOS ENRIQUE (contact);MORRISON, THOMAS E

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;Address;Antibodies;Antibody Response;Antigen Presentation;Antigens;Arboviruses;Area;atomic layer deposition;Avidity;B-Lymphocytes;Bacteriophages;Biological;Biological Products;Chikungunya virus;Chiroptera;Cold Chains;Coronavirus;coronavirus vaccine;COVID-19 pandemic;Data;design;Development;Disease;Dose;Ebola virus;emerging pathogen;Engineering;Formulation;Future;Generations;Goals;Health;Humanities;Immunize;immunogenicity;Immunologics;Infection;influenzavirus;Intramuscular;lambda-Like Phages;large scale production;Libraries;Ligands;macromolecule;Memory;Middle East Respiratory Syndrome Coronavirus;Molecular Conformation;Morbidity - disease rate;mortality;mosaic;Mus;nanoparticle;neutralizing antibody;novel;Outcome;pandemic coronavirus;Paramyxovirus;particle;pathogen;Pathogenicity;Pathologic;Pharmaceutical Preparations;Polymers;Polynucleotides;Preparation;Property;protective efficacy;Proteins;Public Health;Publishing;Rapid screening;receptor binding;response;RNA vaccine;SARS coronavirus;SARS-CoV-2 immunity;SARS-CoV-2 variant;screening;Severe Acute Respiratory Syndrome;stem;Surface;System;T cell response;Technology;Testing;thermostability;tool;vaccine candidate;vaccine development;vaccine distribution;vaccine evaluation;vaccine formulation;vaccine platform;Vaccines;Variant;Viral;virtual;Virus;weapons of mass destruction;Zika Virus

PROJECT_TITLE: A Tunable Nanophage Platform for Vaccine Development


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Chronic Pain;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pain Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: The University of Utah Program to Provide Pain Research Knowledge (UP3RK) mission is to impart the  science knowledge, skills, and core competencies needed by post-graduate, interdisciplinary Scholars  to address the nation’s scientific needs in clinical pain research. UP3RK trains Scholars through mentorship  and concentrated training in: 1) our four focus areas (nonpharmacological pain treatments; effective  interventions for pain and co-morbidities, particularly substance use disorders; implementation science;  research within vulnerable, diverse, and underserved populations), 2) career development and programmatic  skills, and 3) interdisciplinary research skills. We train Scholars through dedicated UP3RK Mentors within an  innovative, multi-level mentor model develop independent clinical pain investigators and successful academic  research careers.

PI_NAMEs: FRITZ, JULIE M (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Address;Area;Behavioral;career;Career Choice;career development;Characteristics;Charge;chronic pain;Clinical;clinical pain;Clinical Research;cohort;Communication;comorbidity;Competence;Dedications;Educational Curriculum;effective intervention;Ensure;Environment;Evaluation;Funding;Grant;Health;implementation science;improved;innovation;Institution;Interdisciplinary Study;Knowledge;Medicine;Mentors;Mission;Modeling;next generation;novel;Pain;Pain management;Pain Research;Persons;Population Heterogeneity;Process;programs;recruit;Research;Research Personnel;Research Support;Science;Scientist;skills;Substance Use Disorder;Training;Training Activity;training opportunity;Underserved Population;Universities;Utah;Vulnerable Populations;Writing


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE This administrative supplement will solve an urgent unmet need in highly-multiplexed spatial imaging, namely the lack of imaging calibration standards to allow batch correction and comparison of data across technologies. To realize this goal, we develop computational tools for analysis of spatial imaging data from “micro-capsules”, and we capture cell lysates within capsules to establish them as highly uniform calibration standards for multiplexed imaging.

PI_NAMEs: PFISTER, HANSPETER  (contact);SANTAGATA, SANDRO

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Acceleration;Acute;Administrative Supplement;Affinity;Algorithmic Software;Antibodies;Atlases;Benchmarking;Binding;Biological Assay;Calibration;capsule;Cell Separation;Cells;Clinical;Collaborations;Complex;complex data;computational suite;computerized tools;crosslink;Cytometry;Cytotoxic agent;Data;data quality;Data Set;data standards;Dedications;Development;digital;digital pathology;dimension reduction;Elements;Ensure;Evolution;experimental study;Genomics;Goals;Grant;high dimensionality;Human;Hydrogels;Image;Image Analysis;imaging modality;Immune;Immune checkpoint inhibitor;Individual;insight;Institution;Laboratories;Location;Maps;medical schools;Messenger RNA;Methods;Microcapsules drug delivery system;Microfluidics;Microspheres;Modality;Modification;Molecular;Morphology;multiple omics;multiplexed imaging;new technology;Noise;novel;Nucleic Acids;parent grant;particle;Permeability;Phenotype;Population Heterogeneity;Productivity;Prognosis;programs;Quality Control;Reagent;Reproducibility;Resources;Running;Sampling;Services;Signal Transduction;single-cell RNA sequencing;Slide;Software Engineering;Specimen;Stains;Standardization;Stromal Cells;Surveys;targeted treatment;Technology;Testing;Time;Tissue imaging;Tissue Microarray;Tissues;tool;transcriptomics;tumor;tumor microenvironment;Variant;Visual;Visualization;web platform;Work

PROJECT_TITLE: IMAT-ITCR Collaboration: Multiplexed Spatial Data calibration and analysis using micro-capsules


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Physical Activity;Prevention

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Contact PD/PI: Miller, Michael E Project Narrative While there are many important health benefits of physical activity, how exercise exerts its effects is not fully understood. A more comprehensive understanding of the molecular mechanisms underlying the responses to exercise would significantly impact public health. Continuation of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) will achieve its objective of generating a comprehensive map of the molecular responses to acute exercise and exercise training. with a long-range goal of elucidating the mechanisms by which exercise improves health.

PI_NAMEs: ESSER, KARYN A;MILLER, MICHAEL E. (contact);REJESKI, WALTER JOHN;TRACY, RUSSELL P

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: actigraphy;Acute;Algorithms;analytical method;Ancillary Study;Animals;Area;Bioinformatics;Biological;Biological Specimen Banks;Certification;Chemicals;Clinic;Clinical;Clinical Data;Clinical Management;clinical research site;Clinical Trials Data Monitoring Committees;Code;cohort;Communication;Data;data management;Data Set;design;Documentation;Dual-Energy X-Ray Absorptiometry;endurance exercise;Equation;Exercise;exercise intervention;exercise training;Florida;Future;Gait;Goals;Health;Health Benefit;Heart Rate;Human Resources;improved;Information Technology;innovation;Intervention;Investigation;Knowledge;Language;Lead;Manuals;Maps;Measures;medical schools;meetings;Meta-Analysis;Modeling;Molecular;Monitor;Multi-Institutional Clinical Trial;multidisciplinary;Online Systems;Phenotype;Physical activity;Posture;pre-clinical;Procedures;Process;Public Health;Publishing;Qualifying;Quality Control;Randomized;Recommendation;recruit;Reporting;Reproducibility;Research;Research Personnel;resistance exercise;Resource Sharing;response;Safety;Sampling;Science;Site;Site Visit;Source;Standardization;success;Suspensions;Time;tool;Training;Transducers;United States National Institutes of Health;Universities;Vermont;Work;working group;Writing

PROJECT_TITLE: MoTrPAC CCC Supplement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE This research training program addresses a critical need by preparing young physicians for visionary and committed research careers in basic, as well as translational and clinical sciences that improve digestive health, including health care delivery and equity. This program will provide rigorous and personalized training that enables emerging researchers to accelerate the translation of discoveries into new approaches to the diagnosis and management of gastrointestinal and hepatic diseases.

PI_NAMEs: COHEN, DAVID E. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Gastrointestinal Diseases;Liver diseases;Research Training

PROJECT_TITLE: Research Training in Gastrointestinal and Hepatic Diseases


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Immunotherapy;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Project Narrative The recurrent herpes simplex virus (HSV)-1 infection of the cornea causes a vision-impairing chronic inflammatory condition called herpetic stromal keratitis (HSK). This project aims to investigate the molecular mechanisms for HSV-1-mediated macrophage metabolic reprogramming and how immunoregulatory cytokine IL-27 promotes antiviral and anti-inflammatory responses during HSK pathogenesis. Since current HSK treatment approaches are partially effective and cause severe side effects, the information gained from these studies will identify novel targets for developing new therapies to treat recurrent HSK.

PI_NAMEs: SURYAWANSHI, AMOL  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Adrenal Cortex Hormones;Affect;Anti-Inflammatory Agents;Anti-viral Agents;Anti-viral Response;antiviral immunity;Attenuated;Blindness;Chronic;Citrates;Citric Acid Cycle;Clinical;Complement;Cornea;Cyclic GMP;cytokine;Data;Dendritic Cells;Down-Regulation;ds-DNA;Enzymes;Eye Infections;GATA1 gene;Genes;Glycolysis;Herpes stromal keratitis;Herpesvirus 1;Herpetic Keratitis;Immune;immune cell infiltrate;Immune Evasion;Immune response;Immunity;immunoregulation;Immunosuppression;Immunotherapy;Impairment;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;interest;Interferon alpha;Interferon Type I;Interferon-beta;Interferons;ISG15 gene;Keratitis;Knock-out;Knockout Mice;Knowledge;Macrophage;Mediating;Metabolic;metabolic phenotype;Metabolism;Mitochondria;Molecular;mouse model;Multi-Drug Resistance;Mus;novel;novel therapeutics;nuclear factor-erythroid 2;Outcome Study;Pain;pathogen;Pathogenesis;Pathway interactions;Patients;Phagolysosome;pharmacologic;Pilot Projects;Play;Predisposition;primary outcome;Production;programs;receptor;Recurrence;Regulation;Resistance;response;Risk;Role;Severities;side effect;Stimulator of Interferon Genes;Testing;Treatment Efficacy;Tricarboxylic Acids;United States;Viral;Virus;Virus Diseases;Virus Replication;Vision;Visual impairment

PROJECT_TITLE: Il-27-mediated immunoregulation in HSV-1 induced stromal keratitis


ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: The proposed research is relevant to public health because it focuses on optimizing outcomes for patients with severe aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). Results from this study have the potential to change antithrombotic therapy guidelines for patients with valvular heart disease. The proposed work is relevant to the NHLBI's strategic goals to not only more effectively treat aortic stenosis but also, by advancing understanding of the thromboinflammatory response, improve thromboembolic and bleeding outcomes.

PI_NAMEs: LYNCH, DONALD RAY (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Acute;adverse outcome;Affect;aortic valve;aortic valve replacement;Aortic Valve Stenosis;Blood flow;Blood Platelets;calcification;Characteristics;Clinical;Clinical Research;Coagulation Process;cost;Data;Development;efficacious treatment;Event;FDA approved;Foundations;Functional disorder;Generations;Goals;Guidelines;Healthcare Systems;Heart;Heart Valve Diseases;Heart Valves;Hemorrhage;Hemostatic Agents;Hospitalization;Hour;improved;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;innovation;insight;Knowledge;Mass Spectrum Analysis;Measures;Mediating;monocyte;mortality;National Heart, Lung, and Blood Institute;Observational Study;Operative Surgical Procedures;Outcome;Pathologic;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;Platelet aggregation;Procedures;prospective;Protein Disulfide Isomerase;Public Health;Research;response;Risk;Risk Factors;risk mitigation;Role;Sampling;secondary analysis;surgical risk;Surrogate Markers;System;Technology;Testing;Thrombin Receptor;Thrombocytopenia;thromboinflammation;Thromboplastin;thrombotic;Time;treatment choice;Work

PROJECT_TITLE: Platelets and Hemostatic Factors as Facilitators of the Inflammatory Response Following Transcatheter Aortic Valve Replacement

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Cardiovascular;Congenital Structural Anomalies;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: LEXINGTON

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Marfan syndrome is a genetic condition that causes thoracic aortic aneurysm, a life-threatening dilation of the largest blood vessel in the body. This research project will examine how statin medicines prevent thoracic aortic aneurysm growth and whether they add benefit to the medicines currently used to treat thoracic aortic aneurysm in Marfan syndrome.

PI_NAMEs: SHEPPARD, MARY BURCHETT (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Adrenergic Receptor;Aneurysm;Angiotensin Receptor;Animal Model;antagonist;Aorta;Aortic Aneurysm;Aortic Diseases;Aortic Rupture;Area;ascending aorta;Atenolol;Attenuated;Basic Science;Biological Assay;Blood Vessels;career;Cause of Death;Cell Fractionation;Cell membrane;Cellular Membrane;Cholesterol;Cholesterol Homeostasis;Clinic;Clinical Research;clinically relevant;college;Confocal Microscopy;Cultured Cells;Data;Diagnosis;Disease;Dissection;Elasticity;Elastin;Etiology;experimental study;Faculty;farnesyl pyrophosphate;Farnesyl Transferase Inhibitor;farnesylation;FBN1;Fluorescence-Activated Cell Sorting;Funding;Future;Gel;Gelatinase A;Genetic Diseases;Genetic Predisposition to Disease;Goals;Growth;Human;Hypertension;Immunohistochemistry;in vivo;Incubated;Infusion procedures;insight;interest;Kentucky;Laboratories;Laboratory Study;Lead;Learning;Leukocytes;Life;Losartan;Marfan Syndrome;Matrix Metalloproteinases;Measurement;Measures;Medical Genetics;Medicine;Mentors;Microscopy;mouse model;Mus;new therapeutic target;novel therapeutics;Operative Surgical Procedures;Oxidoreductase;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physicians;Plasma;Pravastatin;pre-clinical research;prevent;Production;professor;Proteins;Publications;RAS inhibition;Regimen;Renin-Angiotensin System;repaired;Research;Research Personnel;Research Project Grants;Retrospective Studies;Risk;Scientist;Senior Scientist;sexual dimorphism;Signal Transduction;Signaling Molecule;skills;Smooth Muscle Myocytes;standard of care;Techniques;Testing;Therapeutic Uses;Thoracic aorta;Thoracic Aortic Aneurysm;Tissues;Training;Transforming Growth Factor beta;translational study;ultra high resolution;ultrasound;United States National Institutes of Health;Universities;Vascular Diseases;Vascular Smooth Muscle;Work

PROJECT_TITLE: Pharmacological Mechanistic Insights into Thoracic Aortic Aneurysm


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Mental Health;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PI_NAMEs: KRACHT, CHELSEA L (contact);THYFAULT, JOHN P

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: adaptive intervention;Address;Affect;Behavior;behavior change;Behavioral;Body Weight decreased;Communities;coping;design;Development;Ecological momentary assessment;Health behavior;improved;Individual;Intervention;Kansas;lifestyle intervention;Measures;Mental Health;Metabolism;Methodology;Obesity;Participant;perceived stress;Persons;Physical activity;Play;Prevalence;programs;psychologic;Psychological Factors;Research;Sleep;Stress;Stress and Coping;success;Testing;Time;Weight;weight loss intervention;weight loss program;Weight maintenance regimen

PROJECT_TITLE: longitudinal assessment of stress and stress-related concepts across a behavioral weight loss intervention


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: The fellows and mentors trained by this program will contribute to short- and long-term improvements in global health. In collaboration with 21 low- and middle-income country institutions, fellows’ research will help develop clear and effective programs and policies to advance global public health, including care for HIV, other infectious diseases, noncommunicable diseases, global surgery, cancer, mental health and addiction, sexual and reproductive health, and planetary health.

PI_NAMEs: COHEN, CRAIG R (contact);LEE, SUNG-JAE ;MARTIN, NATASHA ;MARTÍNEZ-LÓPEZ, BEATRIZ

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TERMS: burden of illness;California;career;career development;Collaborations;Country;Dentistry;design;Discipline;Discipline of Nursing;Ensure;Environmental Science;Equity;Evaluation;experience;faculty mentor;Faculty Recruitment;Fellowship;Fostering;Funding;global health;Goals;hands on research;Health;improved;Income;innovation;Institution;Instruction;Interdisciplinary Education;Leadership;Los Angeles;Medicine;Mentors;Mentorship;Modeling;National Institute of Environmental Health Sciences;online course;Personal Satisfaction;Postdoctoral Fellow;pre-doctoral;programs;Public Health;Race;recruit;Research;Research Methodology;Resources;response;San Francisco;Site;Social Sciences;success;Training;Training and Education;Training Programs;Underrepresented Minority;Universities;veterinary science;Work

PROJECT_TITLE: GloCal - NIEHS - Zambrano-Romero


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

PHR: The VA is the largest single provider of HIV care in the US and Veterans with HIV use significantly more healthcare services and have a 1.5-2x higher risk of atherosclerotic cardiovascular disease (ASCVD) compared to uninfected Veterans. Our goal is to improve BP treatment for Veterans with HIV to reduce ASCVD risk. Within a RCT, we hypothesize that our VA adapted nurse-led intervention will result in a clinically significant 6mmHg reduction in SBP over 12 months compared to those receiving enhanced education only. The study is innovative because of the use of stakeholder-engaged design process, multi-component nurse-led intervention, and VA Video Connect (VVC) to monitor CVD risk factors. The project meets VA strategic priorities including: 1) greater choice for Veterans; 2) improve timeliness of services; 3) focus more resources more efficiently (strengthen foundational services in VA). If shown to be effective, this intervention will have substantial impact among high-risk Veterans, potentially reducing ASCVD events by more than a quarter.

PI_NAMEs: BOSWORTH, HAYDEN B (contact)

PROJECT_TERMS: Achievement;Address;Adherence;Aging;antiretroviral therapy;Atherosclerosis;atherosclerosis risk;Blood Pressure;blood treatment;budget impact;cardiovascular disorder prevention;cardiovascular disorder risk;care coordination;Caring;Chronic Disease;Clinic;Clinical;clinically significant;Complex;Computerized Medical Record;connected care;cost effectiveness;design;Diagnosis;Disease remission;Dose;Education;Educational Materials;Electronic Health Record;Ensure;Evaluation;Event;evidence base;Evidence based intervention;experience;formative assessment;Funding;Goals;Guidelines;Health;health care availability;health care service;health equity;Health Personnel;Health Promotion;Health Services Accessibility;Healthcare;high risk;HIV;HIV/AIDS;Home Blood Pressure Monitoring;Hyperlipidemia;hypertension control;implementation facilitation;improved;innovation;Intervention;intervention delivery;Interview;iterative design;Managed Care;medical specialties;Medication Management;member;Methodology;Methods;Modeling;Monitor;Nurses;nursing intervention;Pathway interactions;Patient-Centered Care;Patients;Perception;Persons;Population;prevent;prevention evaluation;Prevention therapy;primary care practice;primary outcome;Process;process evaluation;programs;Protocols documentation;Provider;Randomized;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;remote delivery;Research Design;Research Methodology;Research Priority;Resources;Risk;Risk Factors;Risk Reduction;screening;secondary outcome;Services;Site;support tools;telehealth;Testing;therapy design;tool;treatment arm;treatment as usual;United States;uptake;Veterans;Veterans Health Administration;Viral;virtual healthcare;Virus;Work

PROJECT_TITLE: A nurse-led intervention to extend the Veteran HIV treatment cascade for cardiovascular disease prevention (V-EXTRA-CVD)

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Infectious Diseases;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE Periodontitis is a chronic disease affecting millions of people globally and has complex underlying cellular and molecular drivers. Here, we aim to leverage a systems biology functional approach to dissect the cellular states driving periodontitis and the added burden of type 2 diabetes. We will characterize clinical samples by single- cell expression profiling, perform advanced computational analyses, and test regulators of cell state and signaling that may offer future novel therapeutic targets.

PI_NAMEs: MOMEN HERAVI, FATEMEH  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Affect;Anti-Inflammatory Agents;Apoptotic;Automobile Driving;Bioinformatics;Biological;Black Populations;Blood specimen;Cell Physiology;Cells;Chronic;Chronic Disease;Circulation;Clinical;college;Complex;Computer Analysis;Data Analyses;Dental;Disease;Disparity;Down-Regulation;Epigenetic Process;ethnic minority population;Ethnic Origin;Event;Funding;Future;gain of function;Gene Expression;Genetic Transcription;Gingiva;Goals;health disparity;Health Services Accessibility;Heterogeneity;Immune;immune checkpoint;Immune Tolerance;Individual;Inflammation;Inflammatory;innovation;Label;Link;loss of function;low socioeconomic status;Macrophage;Macrophage Activation;Medicine;Metabolic;Methodology;Methods;microbial;Minority;Minority Groups;Molecular;Molecular Target;monocyte;Myelogenous;Myeloid Cells;Natural Immunity;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Pathogenesis;Pathway interactions;Patients;PD-1 pathway;PD-1/PD-L1;Periodontitis;peripheral blood;Persons;Phenotype;Play;Population Heterogeneity;Positioning Attribute;Predisposition;Prevalence;programmed cell death ligand 1;Race;racial minority population;recruit;Reporting;Resolution;Risk;Risk Factors;Role;Sampling;Severities;Signal Transduction;single-cell RNA sequencing;systemic inflammatory response;Systems Biology;Techniques;Testing;Therapeutic;Thinking;Tissue Sample;Tissues;Tooth Loss;transcriptomics;Translational Research;Universities;Work

PROJECT_TITLE: Single-cell RNA-sequencing for functional analysis of monocytes and macrophages in periodontitis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases;Social Determinants of Health

ORG_CITY: Peachtree Corners

ORG_NAME: KASA BIO, L.L.C.

ORG_STATE: GA

PHR: Project Narrative Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL). There are two major biologically distinct molecular subtypes of DLBCL, germinal center B-cell (GCB) and activated B- cell (ABC). Differentiation of these subtypes is crucial for the right treatment. The goal of this SBIR phase I proposal is to develop a Zip-MeltTM DLBCL Classifier Assay to differentiate these subtypes using Zip-MeltTM Multiplex Probe Technology in a single qPCR reaction. This high multiplex assay will be quicker, simple to perform, cost-effective, and will address the molecular diagnostic need, especially, for resource limited setting and will be ecofriendly.

PI_NAMEs: MADANAHALLY DIVAKAR, KIRAN  (contact)

PROGRAM_OFFICER_NAME: BILLINGSLEA, EDDIE

PROJECT_TERMS: B-Cell Activation;B-Lymphocytes;Biological Assay;Chemicals;Chemistry;Clinical;clinical practice;clinically significant;cost;cost effective;Detection;detection platform;Development;Diagnosis;Gene Expression Profile;Gene Expression Profiling;Genes;genetic signature;Goals;Health Care Costs;large cell Diffuse non-Hodgkin's lymphoma;Lymphoma;Malignant Neoplasms;molecular diagnostics;molecular subtypes;Monitor;multiplex assay;Non-Hodgkin's Lymphoma;outreach;Performance;Phase;Plastics;Point-of-Care Systems;Reaction;Reagent;Recurrence;Resource-limited setting;Sampling;Small Business Innovation Research Grant;Structure of germinal center of lymph node;study characteristics;System;Technology;Time;wasting

PROJECT_TITLE: A multiplex platform for quantitative analysis of clinically important gene expression signatures


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Pulmonary Hypertension

ORG_CITY: IRVINE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: NARRATIVE Right ventricular failure (RVF) is a prevalent cause of cardiovascular collapse and a major public health problem. Unlike left ventricular failure, RVF is not frequently investigated, which has contributed to the lack of effective therapies for RVF. Here we propose to use computational model predictions, based on state-of-the-art, multi- scale, comprehensive experimental datasets, to improve our understanding of RVF.

PI_NAMEs: BAKER, ANTHONY J.;BEARD, DANIEL A;CHESLER, NAOMI C (contact);JANSSEN, PAULUS ML

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Adult;Affect;Apoptosis;Biological Assay;Blood capillaries;Cardiac;Cardiac Output;cardiovascular collapse;Cause of Death;Computer Models;constriction;coronary fibrosis;crosslink;Data;Data Set;Disease;effective therapy;exercise capacity;exercise intolerance;experience;experimental study;Exposure to;Failure;Fibrosis;Functional disorder;Generations;Goals;Hand;Heart;Human;human disease;Human Rights;Hypertrophy;Impairment;improved;in vivo;Individual;Kinetics;Left;Measurement;Measures;Mechanics;Microfilaments;Mitochondria;Modeling;Morbidity - disease rate;mortality;multi-scale modeling;Muscle Cells;Myocardial tissue;Myocardium;Nature;Necrosis;novel;Organ;Organelles;Organism;Oxidative Stress;Patients;Phenotype;predictive modeling;preservation;pressure;prevent;Protocols documentation;Public Health;pulmonary arterial hypertension;Pulmonary artery structure;pulmonary vascular remodeling;Rattus;Relaxation;Respiration;right ventricular failure;Right ventricular structure;Rodent;Rodent Model;Sampling;Severities;Techniques;Testing;Time;Tissues;Ventricular;Whole Organism;Work

PROJECT_TITLE: Multiscale mechanobiology of right ventricular failure

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ORG_CITY: WEST LAFAYETTE

ORG_DEPT: CHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative  Synthetic methods that rapidly generate complex organic molecules are critical for the development of selective biological probes and therapeutics. The overarching goal of this project is to explore transition metal redox catalysts for the reductive generation of carbene equivalents from readily available gem-dihalo starting materials. Using this approach, we will develop cycloaddition reactions that form odd-membered rings and vinylidene carbon–carbon coupling reactions that form chiral building blocks.

PI_NAMEs: UYEDA, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Transition Metal Catalyzed Reductive Carbene Transfer Reactions


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Natural Products;Neurosciences;Nutrition;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: OMAHA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project narrative Smith-Lemli-Optiz syndrome (SLOS) is a genetic, developmental disorder arising from impaired sterol biosynthesis. We will test three already approved medications that can potentially improve the disrupted sterol function, using a mouse model of SLOS. Furthermore, we will perform a high throughput screening to identify which of the >2,500 molecules in a library of natural compounds can be important complementary drug candidates for treatment of SLOS in patients with various underlying gene mutations and health conditions.

PI_NAMEs: KORADE, ZELJKA ;MIRNICS, KAROLY  (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: 7-dehydrocholesterol;Affect;Anabolism;Antioxidants;autism spectrum disorder;Award;behavioral phenotyping;Biochemical;Biological;Biology;Brain;career;Cells;Cerebellum;Cholesterol;cholesterol biosynthesis;Clinical;Clinical Trials;Collection;Combination Medication;Complex;Conceptions;Coupled;Data;Dermal;Desmosterol;Development;developmental disease;Diet;Disease;drug candidate;drug discovery;Drug Prescriptions;enzyme pathway;Enzymes;experimental study;Fibroblasts;follow-up;frontal lobe;Functional disorder;Gene Expression Profile;Gene Mutation;gene therapy;Genes;Genetic;Health;Heart;Hereditary Disease;Heterozygote;high throughput screening;high-throughput drug screening;Hippocampus;Human;Hydroxyzine;Impairment;improved;In Vitro;in vivo;Kidney;Knowledge;Lanosterol;Libraries;Lipids;Liver;Lung;Measurement;Measures;Mediating;Metabolism;Methods;Midbrain structure;mother nutrition;mouse model;Mus;Mutation;Natural Compound;Natural Products;neurochemistry;Neuroglia;Neurons;Nobel Prize;Oxidoreductase;Pathogenicity;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Physiological;postnatal;Process;Recording of previous events;Residual state;Role;Scientist;sex;Site;small molecule;Smith-Lemli-Opitz Syndrome;Sterol Biosynthesis Pathway;Sterols;Supplementation;symptomatic improvement;Symptoms;Syndrome;Testing;Therapeutic Uses;Toxic effect;Transgenic Mice;Transgenic Organisms;United States National Institutes of Health;Valproic Acid;Vitamin E;Wild Type Mouse;Work;ziprasidone

PROJECT_TITLE: Reversing disrupted developmental sterol biosynthesis by prescription medications