NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Gene Therapy;Genetic Testing;Genetics;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Project Narrative The proposed research is focused on efficiently identifying the genetic cause of inherited retinal degenerations (IRDs), an important cause of vision loss. By using cell-based assays to determine the functional significance of a large panel of DNA variants, the goal is to increase the throughput of diagnosing IRDs. The application of this knowledge could directly increase the number of inherited retinal disease patients eligible for gene-specific treatments such as gene augmentation therapy, reducing illness and disability from these blinding diseases.

PI_NAMEs: COMANDER, JASON  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Address;Amino Acids;Antisense Oligonucleotide Therapy;Benign;Biochemical;Biological Assay;Blindness;Calibration;Cells;Classification;Collection;Data;Data Analyses;Data Set;Deposition;Detection;Diagnosis;disability;Disease;disease-causing mutation;DNA;Dose;Eligibility Determination;Etiology;experience;experimental study;FDA approved;gene augmentation therapy;gene therapy;Genes;Genetic;genetic counselor;genetic disorder diagnosis;Genetic Polymorphism;genetic testing;Goals;Hereditary Disease;Human;improved;Inherited;inherited retinal degeneration;interest;Investigation;Knowledge;large datasets;Measures;Medical;Molecular Chaperones;Mutation;Outcome;Pathogenicity;Pathway interactions;Patients;Pharmacogenomics;pharmacologic;phenotypic data;preservation;prevent;proband;protein folding;prototype;public database;Recording of previous events;Research;Research Personnel;Resources;response;Retinal Degeneration;Retinal Diseases;Retinitis Pigmentosa;retinol isomerase;Rhodopsin;RPE65 protein;sight restoration;small molecule;Techniques;Testing;Time;Toxic effect;Translating;Validation;Variant;variant of unknown significance;Vision;Work

PROJECT_TITLE: Improving the throughput of diagnosis and treatment of inherited diseases of the retina

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Dietary Supplements;Mental Health;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PUBLIC HEALTH RELEVANCE Through analysis of tooth biomarkers, in utero neural development, psychosocial environment during early childhood, and multiple indicators of child neurobehavioral development, we will achieve better mechanistic understanding of neurodevelopmental sequelae associated with micronutrient and toxicant exposures during pregnancy. Further, by assessing potentially modifiable psychosocial environmental factors, this work has potential to inform development of novel prevention and intervention strategies.

PI_NAMEs: MARTINEZ, MAURO ;THOMASON, MORIAH E (contact);TRENTACOSTA, CHRISTOPHER J

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Address;Affect;Age;Area;Arsenic;Attention;Attention deficit hyperactivity disorder;Behavioral;Belief;Biological;Biological Assay;Biological Markers;Birth;Brain;Buffers;Cadmium;Chemicals;Child;Childhood;cognitive control;cohort;connectome;Copper;Data;Data Collection;deciduous tooth;Development;Dorsal;early childhood;Elements;Enrollment;Environment;Environmental Exposure;Environmental Risk Factor;Event;executive function;Exposure to;externalizing behavior;Family;fetal;Fetus;follow-up;Functional Magnetic Resonance Imaging;Health;High Prevalence;Human;human fetal brain;in utero;indexing;innovation;insight;interest;Intervention;Knowledge;Lead;Link;Lithium;Magnesium;Magnetic Resonance Imaging;Manganese;Measurement;Measures;Methodology;micronutrient deficiency;Micronutrients;Modeling;Mothers;neural;neural circuit;neural network;neurobehavioral;neurobehavioral disorder;neurodevelopment;neuroimaging;novel;Nutrient;Nutrient availability;Nutritional;Nutritional status;offspring;Outcome;Parent-Child Relations;Parents;Participant;Pathway interactions;Performance;Perinatal;Personal Satisfaction;postnatal;Pregnancy;prenatal;prenatal exposure;Prevention strategy;Problem behavior;promote resilience;Property;protective factors;psychologic;psychosocial;public health relevance;Readiness;Research;Rest;Risk;risk mitigation;Schools;Second Pregnancy Trimester;sex;Signal Transduction;Statistical Models;Sum;System;Techniques;Technology;Testing;Third Pregnancy Trimester;Time;Tin;Tooth structure;toxicant;Toxicant exposure;Uterus;Variant;Weight;Work;Zinc

PROJECT_TITLE: From the womb to the classroom: Linking perinatal micronutrients and toxicants to neural and behavioral development in utero and in childhood


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Hydrocephalus;Neurosciences;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Stroke

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSURGERY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Intraventricular hemorrhage in very preterm infants leads to posthemorrhagic hydrocephalus, which currently can only be treated with surgery. Most often these procedures entail placement of ventricular shunts that incur a lifelong burden of malfunction, infection, hospitalization, family disruption and societal costs. Here, we propose a dose-finding, Phase I, randomized, controlled, double-blind trial to evaluate the safety of re-purposed medications, melatonin and erythropoietin, in very preterm neonates with recent-onset severe intraventricular hemorrhage.

PI_NAMEs: ROBINSON, SHENANDOAH  (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: absorption;Affect;Age;Biological Markers;Brain;Brain Injuries;brain magnetic resonance imaging;brain repair;Calpain;Caring;Cell Physiology;Central Nervous System;Cerebral Palsy;Cerebrospinal Fluid;Cessation of life;Child;cilium motility;Clinical;clinical imaging;Clinical Trials;Clinical Trials Design;clinically relevant;combinatorial;Combined Modality Therapy;comorbidity;Complex;Data;design;Development;Diagnosis;Dose;Dose Limiting;Double-blind trial;drug repurposing;efficacy clinical trial;efficacy testing;endoplasm;Enrollment;Enzymes;Epilepsy;Erythropoietin;Event;extreme prematurity;Face;Family;fetal;Fluids and Secretions;follow-up;Future;glymphatic system;Head;Health Care Costs;Hemorrhage;high risk;Hospitalization;Hydrocephalus;Hypertension;Image;Impairment;Incidence;Individual;Indwelling Catheter;Infection;Inflammation;Informed Consent;Injury;insight;Institution;Institutional Review Boards;Intellectual functioning disability;Intervention;intraamniotic infection;intraventricular hemorrhage;iron supplementation;Life;life span;Liquid substance;Liver;liver function;Macrocephaly;Medical;medical complication;Melatonin;Metabolic;mitochondrial dysfunction;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;Natural History;Neonatal;Neonatal Intensive Care Units;neonatal sepsis;neonate;neuroimaging;neuroimaging marker;neuroinflammation;Neurons;neurorestoration;neurosensory;older patient;Operative Surgical Procedures;Outcome;Oxidative Stress;Pathogenesis;patient population;peer;Perinatal;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;phase II trial;Placebos;Polycythemia;Population;postnatal;pre-clinical;Premature Birth;Premature Infant;preterm newborn;prevent;primary endpoint;Problem behavior;Procedures;Process;Randomized;Rattus;recruit;Regimen;Regulation;Reporting;Research Design;research study;Risk;Role;Safety;screening;secondary outcome;Serious Adverse Event;Serum;Shunt Device;Signal Transduction;societal costs;Societies;standard of care;Stress;Structure of choroid plexus;systemic inflammatory response;Testing;Third Pregnancy Trimester;Thrombosis;Thrombus;Time;Toxic effect;trend;ultrasound;Urine;Ventricular

PROJECT_TITLE: Safety of Combinatorial Therapy with Erythropoietin and Melatonin for Preterm Infants with Intraventricular Hemorrhage


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Cachexia;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative  Cachexia is a major predictor of mortality that occurs with almost all chronic diseases. This project will identify the mechanism by which IL-1 promotes cachexia pathophysiology, fibrosis and lipid dysregulation. Effective tools to combat cachexia will impact a wide range of patients by: 1) increasing survival of physically taxing treatment; 2) increasing life span so that new therapies can be implemented 3) reduce debilitating pain and fatigue.

PI_NAMEs: EWALD, SARAH E. (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Animal Model;Animals;Automobile Driving;Cachexia;cell type;Chronic;Chronic Disease;chronic infection;Clinical Research;combat;Complex;cost;debilitating pain;Disease;efficacious intervention;Endothelial Cells;Etiology;extend lifespan;Fatigue;Fibroblasts;Fibrosis;Functional disorder;Human;IL1R1 gene;Immune signaling;improved;Infection;Inflammatory;Interleukin-1;lean body mass;life span;lipid metabolism;Lipids;Liver;Longevity;Modeling;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mus;novel;novel therapeutics;Pathology;Patients;Perivascular Fibrosis;protective pathway;Role;Signal Transduction;Symptoms;Taxes;therapeutic evaluation;Therapeutic Intervention;tool;Toxoplasma

PROJECT_TITLE: Innate Inflammatory Control of Cachexia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE/RELEVANCE Motility is essential for spirochetes to infect and disseminate in mammalian hosts, causing major diseases, such as syphilis, leptospirosis, and Lyme disease. The spirochetal motility is driven by periplasmic flagella, which are uniquely enclosed within bacterial outer membrane and are distinct from external flagella in the model systems Escherichia coli and Salmonella enterica. A better understanding of the unique periplasmic flagella as proposed in the application will potentially lead to the development of new antimicrobial strategies that specifically prohibit spirochetal motility and prevent major human diseases.

PI_NAMEs: LIU, JUN  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Address;antimicrobial;ATP Hydrolysis;ATP phosphohydrolase;Automobile Driving;Bacteria;Binding;Binding Sites;Biochemical;Biological Models;Borrelia burgdorferi;Cell membrane;Chemicals;Chemotaxis;Collaborations;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Development;Disease;Environment;Escherichia coli;experience;Flagella;Funding;Gastrointestinal tract structure;Genetic;Goals;Grant;Health;Human;human disease;In Situ;innovation;Insecta;Interdisciplinary Study;Leptospira interrogans;Leptospirosis;Libraries;Lyme Disease;Mammals;marine;Mastigophora;Mediating;Membrane;Molecular;Molecular Conformation;Morphology;Motility;Motor;mutant;nanometer resolution;Oral cavity;Order Spirochaetales;Organelles;Pathogenicity;Periodontitis;periplasm;Phenotype;Phosphorylation;Phylogenetic Analysis;Positioning Attribute;prevent;protein transport;Proteins;Proton-Motive Force;Protons;recruit;Resolution;Role;Rotation;Running;Salmonella enterica;Signal Transduction;Stimulus;Structure;Structure-Activity Relationship;Switching Complex;Syphilis;Tissues;Torque;Treponema;Treponema pallidum;Virulence;Viscosity;Work

PROJECT_TITLE: Structure-Function Relationships in the Spirochetal Flagellar Motor


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Changes in MicroRNA (miRNA) expression can have profound biological impacts, leading to a variety of human diseases. We propose to perform combined computational and experimental analyses to develop cutting-edge technologies for miRNA studies. Our work is expected to exert a significant impact in the miRNA field by providing valuable resources for functional miRNA analysis.

PI_NAMEs: WANG, XIAOWEI  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Adopted;bioinformatics resource;Biological;Biological Process;Biology;Code;Communities;Computer Analysis;computer studies;experimental analysis;experimental study;Family;Funding;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Grant;Human;human disease;innovation;Methods;MicroRNAs;National Institute of General Medical Sciences;predictive tools;Proteins;Publications;Publishing;Research;Resources;Role;Technology;Untranslated RNA;Work

PROJECT_TITLE: Combined Computational and Experimental Analyses of Gene Regulation by MicroRNAs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Networking and Information Technology R&D (NITRD)

ORG_CITY: FLUSHING

ORG_DEPT: CHEMISTRY

ORG_NAME: QUEENS COLLEGE

PHR: Project Narrative Off-target effects by therapeutic agents are mainly connected to the toxicity of current drug candidates in clinical studies, while achieving specific inhibition of the desired target of interest is a challenging task due to the high degree of similarity among enzymes inside cells. We propose a research plan that combines computational studies, multi-step synthesis, biochemical assay, and structural biology to systematically investigate a family of enzymes and to identify distinct structural features in enzymes of interest. This research will provide new insights into specific inhibition mechanisms for targets of interest, and it aims to produce highly specific chemical agents that may be further developed to new therapeutic candidates.

PI_NAMEs: CHOI, JUN-YONG  (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Amino Acids;Area;beta catenin;Binding;Binding Sites;Biochemical;Biological Assay;Biomedical Research;cancer cell;cancer therapy;casein kinase I;Cell Physiology;Cell Survival;Cells;cellular development;Chemical Agents;Clinical Research;comparative;Complex;Computational Technique;Computer Analysis;computer studies;Computer-Aided Design;Core Facility;design;Development;drug candidate;drug discovery;EIF4EBP1 gene;Electrostatics;Enzymes;Erinaceidae;experience;Family;Future;Goals;Human;human disease;Hydrogen Bonding;Hydrophobicity;Individual;inhibitor;insight;Interdisciplinary Study;interest;Investigation;kinase inhibitor;Knowledge;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;member;Methods;Modernization;Molecular;Molecular Conformation;molecular dynamics;molecular modeling;nanomolar;Neoplasm Metastasis;novel therapeutics;Oncogenes;Patients;Pharmaceutical Chemistry;pharmacologic;Phosphorylation;Phosphotransferases;Physiological;Play;Proliferating;prospective;Protein Isoforms;Protein Kinase;Rationalization;Regulation;Research;Research Project Grants;Resolution;Roentgen Rays;Role;Series;Signal Pathway;Signal Transduction;Signal Transduction Pathway;skills;small molecule;Sodium Chloride;Specificity;structural biology;Structure;Students;Synthesis Chemistry;Techniques;Therapeutic;Therapeutic Agents;therapeutic candidate;therapeutic development;Therapeutic Effect;Tissues;Toxic effect;Tumor Suppressor Proteins;tumorigenesis;Validation

PROJECT_TITLE: Computer-aided design and development of isoform selective inhibitors of Casein Kinase 1


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative Alzheimer's disease (AD) is greatly affected by aging and inflammation. We have discovered that an important antiviral immune response is turned on in AD at later stage when tau protein accumulates in neurons. Here, we will study in detail how such inflammation is triggered by genomic parasites during AD pathogenesis.

PI_NAMEs: CAO, WEI  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Achievement;Affect;aged;Aging;aging brain;aging process;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Anti-viral Response;Biogenesis;Brain;brain cell;Brain Mapping;Brain region;cell type;Cells;Central Nervous System;Chronic;Clinic;cohort;Coupled;cytokine;Defense Mechanisms;derepression;DNA Transposable Elements;Elements;Encephalitis;Epigenetic Process;epigenome;Event;Genetic Polymorphism;Genetic Transcription;Genome;Genomic Instability;Genomics;Gliosis;Goals;hallmarks of aging;Heterochromatin;Human;Immune;Immune response;Immune signaling;In Vitro;in vivo;in vivo Model;Inflammaging;Inflammation;innate immune pathways;Innate Immune Response;insight;Interferons;Invaded;Kinetics;Late Onset Alzheimer Disease;Mediating;Mediator;Methylation;Microglia;Modeling;Modification;Molecular;molecular targeted therapies;Mus;Natural Immunity;Nerve Degeneration;Neuroglia;neuroinflammation;Neurons;novel;Nucleic Acids;Outcome;overexpression;Parasites;Pathogenesis;Pathology;Pathway interactions;Phenotype;phenotypic biomarker;Play;Population;Process;Production;Reaction;Relaxation;Reporter;Reporting;response;Retroelements;Retrotransposition;Role;senescent cell;Senile Plaques;sensor;Signal Transduction;Staging;Synapses;tau Proteins;Tauopathies;Testing;Therapeutic Intervention;transgene expression;Viral;viral detection;Viral Genome;Virus

PROJECT_TITLE: Antiviral response coupled with transposon derepression in Alzheimer's disease and aging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative: This project sees to better understand how cognition, Alzheimer's Disease and other dementias, and cardiometabolic health are affected by and evolve after exposure to extreme stressors from a natural disaster. The project will analyze anthropometrics, blood-based biomarkers, and results of cognitive tests collected from a population differentially exposed to an extreme event. The project will provide critical information on the long-term implications of extreme events for health.

PI_NAMEs: FRANKENBERG, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: acetone hydrazone;Address;Affect;Age;Aging;aging related;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Model;Anthropometry;Area;Attention;Back;Biological;Blood Pressure;blood-based biomarker;cardiometabolic risk;cardiometabolism;Clinical;Cognition;Cognitive;Cognitive aging;cognitive performance;cognitive testing;Communities;Data;data resource;Dementia;Disasters;Disease;Earthquakes;Economics;Emotional;Event;executive function;experience;Exposure to;Family;follow-up;Friends;Health;Home;Household;Human;Impaired cognition;Indian Ocean;Individual;Indonesia;Inflammation;innovation;Knowledge;Light;Link;Literature;Long-Term Effects;Measurement;Measures;Mediating;Natural Disasters;Natural experiment;Nature;Neurosciences;Observational Study;older adult;Outcome;Pathway interactions;Personal Satisfaction;Persons;Physiological;Play;Population;Poverty;Premature Mortality;Prevalence;Process;psychosocial;Public Domains;Random Allocation;reconstruction;Recovery;Research;Research Design;resilience;Resource-limited setting;Resources;Respondent;response;Risk;Role;Science;Shock;Site;Source;Stress;stressor;Sumatra;Surveys;Survivors;Tablets;Time;Tsunami;Water

PROJECT_TITLE: Long-term Effects of a Natural Disaster on Cognitive Aging, Dementia, Health and Well-being of Older Adults

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: Aurora

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative  Craniofacial defects including cleft lip and palate are among the most prevalent birth defects in humans. Dysregulation of alternative RNA splicing has been implicated in a variety of congenital diseases, including human craniofacial defects, which have been shown to stem from misexpression of multiple RNA-binding proteins that regulate alternative splicing. By identifying the molecular mechanisms by which the activity of the the RNA-binding protein Srsf3 is regulated, as well as its alternative RNA splicing targets in facial mesenchyme cells, the research aims in this proposal will provide significant insight into the mechanisms underlying gene expression regulation during mammalian craniofacial development and potentially new therapeutic directions for the treatment of human orofacial clefting.

PI_NAMEs: FORMAN, THOMAS E (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Ablation;Affect;Alleles;Alternative Splicing;Apoptosis;Arginine;Biotinylation;Cell Lineage;Cell membrane;Cell Nucleus;Cells;Cephalic;cleft lip and palate;Cleft Palate;Complex;Congenital Abnormality;Consensus;Consensus Sequence;craniofacial;Craniofacial Abnormalities;craniofacial development;craniofacial structure;crosslink;Cytoplasm;Data;Defect;Disease;Dissociation;Ectoderm;Embryo;Event;experimental study;Face;Feedback;Gene Expression;Gene Expression Regulation;Genes;Goals;Head;Histologic;Human;Immunoprecipitation;In Vitro;in vivo;innovation;insight;interest;knock-down;Knock-in;Knock-in Mouse;Label;Lead;Ligands;Maps;Mass Spectrum Analysis;Mediating;Membrane;Mesenchyme;Molecular;Morphology;mouse model;Mus;mutant mouse model;Mutation;Neural Crest;Neural Crest Cell;novel;novel therapeutics;Nuclear Proteins;nucleocytoplasmic transport;Ontology;orofacial cleft;PDGFRA gene;Phenotype;Phosphopeptides;phosphoproteomics;Phosphorylation;Phosphotransferases;Physiological;PIK3CG gene;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor alpha Receptor;Play;Post-Translational Protein Processing;Pregnancy;Process;Proliferating;Protein-Serine-Threonine Kinases;Proteins;recruit;Research;response;RNA;RNA Binding;RNA Sequences;RNA Splicing;RNA-Binding Proteins;Role;Serine;Signal Transduction;Site;Skeletal Development;Small Interfering RNA;Specificity;stem;Stimulus;Structure;Techniques;Testing;Tissues;Transcript;transcriptome sequencing;Western Blotting

PROJECT_TITLE: Investigating Srsf3-mediated alternative RNA splicing in craniofacial development

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Health Services;Palliative Care;Patient Safety

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The National Academy of Medicine and the National Institutes of Health have called for urgent action to improve the care delivered to the nearly 1,000,000 older Americans who die in intensive care units (ICUs) annually, or survive with substantial impairments. These patients often die with distressing symptoms, receiving more invasive, life-prolonging treatment than they would choose for themselves; their family members, acting as surrogate decision makers, often experience lasting psychological distress from the ICU experience. We will conduct a randomized trial to determine whether early integration of specialty palliative care with standard critical care can improve outcomes for critically ill older patients and their family members.

PI_NAMEs: SCHENKER, YAEL ;WHITE, DOUGLAS B (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Academy;Address;Adopted;Advance Care Planning;advanced dementia;American;Anxiety;Caring;Cessation of life;Coma;Consensus;Consultations;contextual factors;Country;Critical Care;Critical Illness;Data;disability;Distress;Effectiveness;end of life;Ethnography;experience;Family;Family member;follow-up;Fostering;Guidelines;Health Care Costs;health care service utilization;Health system;Healthcare Systems;Heart Arrest;high risk;Hospitals;Impairment;improved;improved outcome;innovation;Intensive Care Units;Intervention;intervention effect;Interview;Length of Stay;Letters;Life;Malignant Neoplasms;Measures;medical information system;medical specialties;Medicine;meetings;Mental Depression;Methods;Monitor;mortality risk;Multicenter Trials;older adult;older patient;Outcome;Outcome Assessment;Palliative Care;Participant;patient oriented;Patient-Centered Care;Patient-Focused Outcomes;Patients;Policy Maker;post-traumatic stress;Prevalence;prevent;primary outcome;Prognosis;psychological distress;psychological symptom;Publishing;Qualitative Methods;quality of death;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Reproducibility;Research;Research Personnel;secondary outcome;Site;Specialist;success;surrogate decision maker;Symptom Burden;Symptoms;Testing;treatment as usual;Treatment Efficacy;United States National Institutes of Health;willingness;Work

PROJECT_TITLE: Randomized Trial of Specialty Palliative Care Integrated with Critical Care for Critically Ill Older Adults at High Risk of Death or Severe Disability

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Relevance GenePattern is a popular bioinformatics software ecosystem that puts sophisticated computational methods within the reach of all biomedical researchers to address a variety of problems at the forefront of cancer research, including patient diagnosis and prognosis, identification of new drug targets, and understanding disease mechanisms. We will continue to support and enhance the system by providing interoperable access to additional software tools and data resources from GenePattern Notebook, a beginning-to-end computational electronic lab notebook environment for combining analysis and text. Moreover, we will expand our collection of notebooks that provide cancer investigators with scientist-oriented cancer analysis scenarios and tasks for use in their own studies.

PI_NAMEs: MESIROV, JILL P. (contact);TAMAYO, PABLO

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;anti-cancer research;Architecture;ATAC-seq;base;Bioinformatics;candidate identification;Clinic;Code;Collection;Communities;Companions;Computational Biology;Computer software;computerized data processing;computerized tools;Computing Methodologies;Custom;Data;data access;Data Analyses;data repository;data resource;Data Set;Development;Diagnosis;Disease;Ecosystem;Educational workshop;Electronics;Ensure;Environment;Explosion;flexibility;Funding;Galaxy;genomic platform;Genomics;Goals;High Performance Computing;improved;Industry;Infrastructure;interoperability;Letters;machine learning method;Malignant Neoplasms;Methods;new therapeutic target;online resource;open source;outreach;Pathway Analysis;patient stratification;Patients;Persons;Physicians;Privatization;Prognosis;programs;Recording of previous events;Reproducibility;Research Personnel;Running;Sampling;Scientist;single-cell RNA sequencing;Site;skills;social media;Software Tools;Suggestion;symposium;System;Technology;technology platform;Text;tool;Training;Translating;Translations;Visualization;webinar;Work

PROJECT_TITLE: GenePattern and GenePattern Notebook: Integrative 'Omic Analysis for Cancer Research


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Dementia;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Patients with Alzheimer’s disease and related dementia (ADRD) are at higher risk of hospitalization and 30-day readmission (readmission) compared to other older adults. Readmission is expensive and increases the risk of institutionalization and premature death among ADRD patients. The main goal of this proposal is to use Michigan Medicine’s electronic health records to develop a tool to identify high-risk ADRD patients.

PI_NAMEs: MAHMOUDI, ELHAM  (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Adherence;Adult;Algorithms;Alzheimer's disease patient;Alzheimer's disease related dementia;American;analytical method;Appointment;Artificial Intelligence;Assessment tool;Award;career;Caregivers;Caring;Cessation of life;Clinical;Cognitive;Communities;comorbidity;cost;Data;Data Science;Diet;Discharge Plannings;Discrimination;Economics;Elderly;Electronic Health Record;electronic health record system;electronic structure;Emergency department visit;Ensure;Familiarity;follow-up;Foundations;frailty;General Population;Goals;Health;health data;Health Expenditures;Healthcare;high risk;hospital readmission;Hospitalization;Hospitals;Impaired cognition;improved;indexing;Influentials;innovation;Institutionalization;Intervention;K-Series Research Career Programs;Length of Stay;Link;Location;Logistics;Machine Learning;machine learning prediction;Measurable;Medical;Medical History;Medicine;Mentors;Mentorship;Methodology;Michigan;multidisciplinary;Natural Language Processing;Nurses;older adult;Outcome;Patient Care;Patient Discharge;patient population;Patients;Persons;Pharmaceutical Preparations;Physicians;Population;predictive tools;Predictive Value;premature;Process;readmission risk;Research;Research Personnel;Resource-limited setting;Risk;Risk Assessment;Risk Factors;Risk Reduction;Sensitivity and Specificity;Services;skills;social;Social Workers;sociodemographics;Socioeconomic Status;Source;statistics;Stress;tool;Training;Training and Education;United States Centers for Medicare and Medicaid Services;unstructured data;Validation

PROJECT_TITLE: Using Machine Learning to Improve Readmission Prediction in Alzheimer's Disease and Related Dementia

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: 8. Project Narrative / Relevance Dementia is a significant public health concern. The proposed studies aspire to develop and validate new strategies for identifying preclinical markers of cognitive decline and dementia based on the ways in which people complete questionnaires in population representative surveys. This research has the potential to enable early detection of dementia with tools that are cost-effective, unobtrusive, and scalable for use in large samples, allowing advanced study of the disease.

PI_NAMEs: SCHNEIDER, STEFAN  (contact)

PROJECT_TERMS: age related changes;Agreement;Behavior;behavioral response;Categories;Clinical;Cognitive;Cognitive deficits;cognitive testing;Complex;Computers;cost effective;Data;Data Aggregation;Data Analytics;Dementia;design;Detection;Development;Disease;Disease Progression;Early Diagnosis;Early Intervention;falls;frailty;functional decline;human old age (65+);Impaired cognition;indexing;Individual;individual response;instrumental activity of daily living;Internet;Measurement;Measures;Methods;mild cognitive impairment;Modeling;multiple datasets;Neurodegenerative Disorders;Neuropsychology;Onset of illness;Participant;Patient Self-Report;Pattern;Performance;Personal Satisfaction;Persons;Phase;Population;pre-clinical;Process;prognostic;Public Health;Questionnaires;Reaction Time;Reproducibility;Research;Respondent;response;Sampling;Series;Signal Transduction;Speed;Step Tests;Surveys;Taxes;Testing;therapy development;tool

PROJECT_TITLE: Testing early markers of cognitive decline and dementia derived from survey response behaviors


ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: NARRATIVE The Yale Women's Reproductive Health Research (WRHR) Career Development Center provides advanced training of obstetricians and gynecologists in basic, translational, and/or clinical science in order to produce the next generation of highly skilled physician-scientists and leaders to contribute to the improvement of women's reproductive health.

PI_NAMEs: TAYLOR, HUGH SMITH (contact)

PROGRAM_OFFICER_NAME: MAZLOOMDOOST, DONNA

PROJECT_TERMS: Advertisements;Advisory Committees;Applications Grants;Basic Science;career;career development;Clinical;Clinical Research;cost;Data;Development;Educational process of instructing;Evaluation;Exhibits;experience;Faculty;Fellowship;Fostering;Funding;Goals;Institution;Instruction;interest;Journals;laboratory experience;laboratory experiment;Letters;meetings;Mentors;Molecular and Cellular Biology;Monitor;next generation;Physicians;Positioning Attribute;Principal Investigator;professor;Program Effectiveness;programs;prospective;Research;Research Personnel;Research Support;Research Training;responsible research conduct;Scientist;skills;success;Time;Training;Training Programs;Translational Research;United States National Institutes of Health;women's reproductive health

PROJECT_TITLE: The Yale WRHR Career Development Center


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative Loss pf p53 function is a pivotal step in cancer etiology and oncogenessis. The recently identified RNA-binding protein, Tudor Domain-interacting Regulator of DNA Repair (TIRR) inhibits function in a multi-faceted manner (i) via regulation 53BP1/USP28/p53 complex and (ii) direct binding of transcripts from p53 target genes. Our proposal utilizes a combination of genomic, proteomic and genetic tools to understand how TIRR inhibits p53 to promote tumor development.

PI_NAMEs: CHOWDHURY, DIPANJAN  (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: 3' Untranslated Regions;access restrictions;Animals;Binding;biobank;Breast;C-terminal;Cancer Biology;Cancer Etiology;Carcinoma;Cell Cycle Arrest;ChIP-seq;Chromatin;clinically relevant;cofactor;Complex;Data;Development;DNA;DNA Binding;DNA Damage;DNA Double Strand Break;DNA Repair Inhibition;Double Strand Break Repair;Gene Expression;Genes;Genetic;Genetic Transcription;Genome Stability;genome-wide;genomic locus;Genomics;global run on sequencing;Heterozygote;Histone H4;Human;Impairment;Li-Fraumeni Syndrome;Literature;Lysine;Malignant Neoplasms;Maps;MDM2 gene;Mediating;Messenger RNA;Mitosis;Molecular;mouse model;mRNA Expression;mRNA Stability;Mus;Mutation;Nuclear;p53-binding protein 1;Pathway interactions;Patients;Pattern;Physiological;Post-Translational Protein Processing;prevent;Proteomics;radiation response;recruit;Regulation;repaired;Reporting;response;RNA Binding;RNA-Binding Proteins;Role;Run-On Assays;Sampling;Signal Transduction;Stress;Testing;tool;TP53 gene;Transactivation;Transcript;Transcription Elongation;transcription factor;Transcription Initiation Site;Transcriptional Activation;transcriptome sequencing;tumor;Tumor Promotion;tumorigenesis;Ubiquitination;Whole-Body Irradiation;Xenograft procedure

PROJECT_TITLE: Elucidating the molecular mechanism and physiological relevance of TIRR mediated inhibition of p53

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-M(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PHR: Project Narrative  Very early identification of Alzheimer’s disease (AD) cognitive vulnerability is difficult because the current gold-standard tests are 1) only sensitive to obvious, not subtle, cognitive impairment, and 2) measure peak performance at a single time point in a well-controlled environment that is detached from how a person functions in day-to-day life. Mobile health (mHealth) assessments that utilize common smartphone technology may help overcome these limitations by sampling cognitive functioning multiple times per day in ‘real-time’, characterizing not only the time-course of a person’s cognitive performance, but also the psychosocial context (e.g., interpersonal interactions, mood, loneliness) in which they are functioning. This study will establish mHealth tools to identify and measure risk and resiliency factors that influence AD symptom development, and ultimately, AD treatment.

PI_NAMEs: WEINSTEIN, ANDREA  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-Protein;Assessment tool;Behavior;Biological;Cellular Phone;Clinical;Cognition;Cognitive;cognitive capacity;cognitive change;cognitive function;cognitive performance;cognitive testing;Cohort Studies;contextual factors;Controlled Environment;cost effective;Data;Dementia;Deposition;Detection;Development;Disease;early detection biomarkers;Early Diagnosis;Early identification;Ecological momentary assessment;Feeling;Foundations;Goals;health assessment;Hippocampus;human old age (65+);Image;Impaired cognition;improved;Individual;individual variation;Interpersonal Relations;Intervention;Knowledge;Life;Loneliness;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mentored Patient-Oriented Research Career Development Award;mHealth;Moods;mortality;Nerve Degeneration;neuroimaging;neuropathology;Neuropsychological Tests;Neuropsychology;novel strategies;older adult;Oranges;Participant;Pattern;Performance;performance tests;Persons;physical state;Positron-Emission Tomography;pre-clinical;Prevention;programs;Protocols documentation;psychologic;psychosocial;Psychosocial Factor;recruit;Reporting;Research;Research Personnel;resilience;resilience factor;Resistance;Risk;Risk Factors;Sampling;Signal Transduction;skills;social engagement;Social Interaction;Social support;Stress;symptomatology;Symptoms;tau Proteins;Technology;Testing;Time;tool;Training

PROJECT_TITLE: Intraindividual Cognitive Variability as an Early Marker of Alzheimer's Disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: PROJECT NARRATIVE Molecular structures of proteins binding other biomolecules provide insight into biological, disease, and drug mechanisms. We will develop foundational tools to predict (1) the three-dimensional structures of protein complexes, including protein-protein interactions where conformational changes complicate predictions; (2) antibody-antigen interactions critical for immunology, diagnostics and therapies; and (3) interactions with glycans, critical modulators of protein function and molecular interactions. Additionally, we will create collaborative infrastructure for the Rosetta biomolecular structure prediction and design software including testing platforms, scripting and web interfaces, and training materials for new scientists.

PI_NAMEs: GRAY, JEFFREY J (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Antibodies;Antigens;Area;Binding;Binding Proteins;Biological;Biological Process;Biophysics;Carbohydrates;Collaborations;Communicable Diseases;Complex;Computer Models;Computer software;Computing Methodologies;design;Development;Diagnostic;Disease;Docking;drug mechanism;Engineering;Health;Human;Immunology;Individual;Industry;Infrastructure;innovation;insight;International;Intervention;Lead;Malignant Neoplasms;Methods;Modeling;Molecular;Molecular Conformation;Molecular Structure;National Institute of General Medical Sciences;operation;Pharmaceutical Preparations;polypeptide;Polysaccharides;Post-Translational Protein Processing;protein complex;Protein Conformation;Protein Engineering;protein function;protein phosphatase inhibitor-2;protein protein interaction;protein structure prediction;Proteins;Resolution;Route;Scheme;Scientist;scripting interface;Software Design;Structure;synergism;Teaching Materials;Testing;three dimensional structure;Tissue Engineering;tool;Training;web interface;web server;Work

PROJECT_TITLE: Prediction of the Structures of Protein Complexes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Sub-optimal transfer of clinical information during inter-hospital transfer (IHT, the transfer of patients between acute care hospitals) is common and can lead to patient harm. To address this problem, we will use key stakeholder input to refine and implement an interoperable health information exchange platform that integrates with the electronic health record and improves the reliability of and access to necessary clinical information in three use cases involving transfer of patients between sending and receiving hospitals with varying levels of affiliation and health record integration. We will assess the effect of this intervention on frequency of medical errors, evaluate the use and usability of this platform from the perspective of those that interact with it, and use these results to develop a dissemination plan to spread implementation and use of this platform across other similar institutions.

PI_NAMEs: MUELLER, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: CHANEY, KEVIN

PROJECT_TITLE: Advancing Health Information (HIE) During Inter-hospital Transfer (IHT) to Improve Patient Outcomes

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Maternal Health;Mental Health;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative Up to 20% of American couples experience infertility and miscarriage, and there are important racial and ethnic disparities in their rates, in access to fertility treatment, and in fertility treatment success. However, little is known about the influence of sleep and selected life stressors on infertility and miscarriage, nor the extent to which male exposures play a role. The proposed prospective study will identify understudied modifiable risk factors for infertility and miscarriage in couples, yielding important public health information about reproductive health.

PI_NAMEs: WISE, LAUREN A (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: 3-Dimensional;actigraphy;Acute;Adult;adverse childhood events;Affect;aged;alpha-amylase;American;Area;Assisted Reproductive Technology;Biological Markers;Black race;Buffers;Child;childhood adversity;Chronic;Cohort Studies;Collection;Conceptions;cost;cost efficient;Couples;COVID-19;Data;design;Discrimination;Emotional;Enrollment;Ensure;ethnic disparity;Ethnic Origin;Etiology;experience;Female;Financial Hardship;fitbit;follow-up;Geography;Hair;Health Care Costs;health goals;Health Services Accessibility;Heterogeneity;high risk;Hour;Hydrocortisone;Indigenous;Infertility;infertility treatment;Infrastructure;Internet;Intervention;Joints;Life;Life Cycle Stages;Low Income Population;male;Measures;Mediating;men;modifiable risk;National Institute of Child Health and Human Development;North America;novel;Occupational;occupational stressor;Occupations;Online Systems;Outcome;Participant;Patient Recruitments;Patient Self-Report;people of color;perceived stress;Perinatal;perinatal outcomes;Physiological;Pilot Projects;Pittsburgh Sleep Quality Index;poor sleep;Population;Pregnancy;Pregnancy loss;Prospective cohort;Prospective Studies;Prospective, cohort study;Public Health;public health intervention;Race;racial discrimination;racial disparity;racism;recruit;reproductive;Reproductive Health;reproductive outcome;Research;Risk;Risk Factors;Rotation;Salivary;Sampling;Selection Bias;shift work;Sleep;Sleep disturbances;Sleep Fragmentations;sleep health;sleep onset;sleep pattern;sleep quality;Social support;Spontaneous abortion;Stratification;Stress;stressor;subfertility;success;Teenagers;time-to-pregnancy;treatment disparity;Underrepresented Populations;United States;Woman;Work

PROJECT_TITLE: An internet-based preconception cohort study in North America

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(90)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cardiovascular;Congenital Structural Anomalies;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative  Large-scale studies have identified thousands of genetic variants linked to developmental defects, together with the regulatory elements harboring these variants and the cell types in which these variants likely function. Yet, the molecular, cellular, and functional phenotypes of each variant remain largely uncharacterized. We propose to establish a center that will systematically catalog molecular and cellular phenotypes for disease- associated enhancers in human development, focusing on elements genetically associated with congenital heart disease (cardiomyocytes), autism (neurons), and placental defects (trophoblasts). Together, our multifaceted and combinatorial approaches will open new horizons to understanding the impact of regulatory variants on developmental disease phenotypes.

PI_NAMEs: HON, GARY CHUNG (contact);KRAUS, WILLIAM LEE;MUNSHI, NIKHIL VILAS

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;Affect;Alleles;autism spectrum disorder;Binding Proteins;Cardiac;Cardiac Myocytes;cardiogenesis;Catalogs;Cell Line;cell type;Cells;Chromatin Loop;Collaborations;combinatorial;Communities;Complex;congenital heart abnormality;Coupling;Data;data interoperability;Data Set;Defect;Detection;Development;developmental disease;Disease;disease phenotype;Disease susceptibility;Elements;Enhancers;Evaluation;experimental study;Foundations;functional genomics;Future;Gene Expression;Gene Expression Regulation;gene network;Gene Targeting;Genetic Transcription;genetic variant;Genetic Variation;Genome;Genome engineering;genome wide association study;genomic variation;Goals;Heterozygote;high throughput analysis;Human;Human Development;human disease;human embryonic stem cell;Human Genetics;human model;Image;improved;insight;Knowledge;late life;Link;Mass Spectrum Analysis;Measures;Molecular;molecular phenotype;Morphology;mosaic;multimodality;neuron development;Neurons;novel;Outcome;Pathway interactions;Patients;Phenotype;Placenta;Placentation;pleiotropism;predictive modeling;Predisposition;recruit;Regulatory Element;Repression;Research Personnel;Resources;Risk;risk variant;RNA;screening;Series;single cell genomics;single cell technology;single-cell RNA sequencing;Techniques;technological innovation;Tissues;tool;trophoblast;Variant

PROJECT_TITLE: Multiscale functional characterization of genomic variation in human developmental disorders


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Primary Health Care

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Up to 80% of clinic visit information is forgotten immediately by patients, a significant impediment to self- management for older adults with multimorbidity, that leads to poor health outcomes. The proposed research will determine the impact of the emerging strategy of audio recording and sharing of clinic visits on the ability of older adult patients to manage their healthcare. It is expected that findings from this project will inform future policy related to the use of audio-recording as part of routine care and guide implementation strategies.

PI_NAMEs: BARR, PAUL JAMES (contact);CAVANAUGH, KERRI ;MASEL, MEREDITH C

PROJECT_TERMS: Address;Adherence;Adoption;Agreement;Award;Behavior;burden of illness;Caregiver support;Caregivers;Caring;Chronic;chronic care model;Chronic Disease;Clinic;Clinic Visits;Clinical;clinical practice;cognitive capacity;comorbidity;Complex;Confusion;Consolidated Framework for Implementation Research;COVID-19 pandemic;Data;Diabetes Mellitus;Diagnosis;efficacy trial;Emergency department visit;Exclusion;Expenditure;experience;forgetting;functional decline;functional status;Future;future implementation;Goals;Health;Health Care Quality Indicators;health care service utilization;Healthcare;high risk;Hospitalization;Hypersensitivity;implementation determinants;implementation facilitators;implementation strategy;improved;Individual;Infrastructure;innovation;Institution;interest;intervention delivery;Interview;Investments;Knowledge;low health literacy;Medical;medical specialties;Medicare;medication compliance;Mental Depression;Modeling;multi-site trial;multiple chronic conditions;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;older adult;older patient;Outcome;Patients;Pharmaceutical Preparations;Phenotype;Policies;poor health outcome;Primary Care;primary care practice;primary outcome;Public Health;Quality of Care;Quality of life;Randomized;Recommendation;recruit;Regimen;Reporting;Research;Resources;retention rate;routine care;Sampling;satisfaction;Schedule;secondary outcome;Self Management;Site;skills;Spanish/English;Structure;systematic review;Testing;Time;treatment as usual;treatment planning;United States National Institutes of Health;uptake;Visit;Work;Writing

PROJECT_TITLE: The effect of clinic visit audio recordings for self-management in older adults

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Stroke;Traumatic Head and Spine Injury

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Stroke is the leading cause of serious long-term disability in the U.S., but current physical rehabilitation strategies do not account for deficits related to cognitive aspects of movement and the hemisphere-specific nature of these movement deficits. The exploratory studies described in this proposal will use a novel paradigm to determine how deficits in cognition affect movement differently depending on side of brain damage and how these differences affect functional independence in chronic stroke survivors. Successful completion of this proposal will provide a strong foundation for developing personalized physical rehabilitation strategies focused on improving both motor and cognitive deficits.

PI_NAMEs: JAYASINGHE, SHANIE AMANDA LIYANAGAMAGE (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Activities of Daily Living;Address;Affect;arm;arm function;arm movement;arm paresis;Behavior;Brain Injuries;chronic stroke;Clinical assessments;clinically relevant;Cognition;Cognitive;Cognitive deficits;cognitive load;cognitive neuroscience;cognitive process;Data;Dependence;design;dexterity;Dissociation;Elbow;Electromyography;evidence base;experience;experimental study;Foundations;functional independence;functional outcomes;Goals;Hand functions;Handedness;hemiparesis;hemisphere damage;Impaired cognition;Impairment;improved;indexing;Individual;kinematics;Knowledge;Left;Literature;Long term disability;Measures;Methods;Motion;Motor;motor control;motor deficit;motor learning;Movement;Muscle;Nature;novel;Paresis;Performance;Physical Rehabilitation;Play;post stroke;Preparation;Process;Reaction Time;recruit;rehabilitation strategy;Rehabilitation therapy;remediation;Research;Role;Short-Term Memory;Shoulder;Side;Standardization;Stroke;stroke rehabilitation;stroke survivor;Surface;System;Testing;Training;Upper Extremity;virtual reality;Work

PROJECT_TITLE: The role of cognitive load on lateralized motor control processes

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

PHR: Project Narrative: Potentially pathogenic members of the intestinal bacteria, namely pathobionts, trigger inflammation in Crohn’s disease (CD). We have identified "IL-1b-inducing pathobionts", which selectively accumulated in patients with CD. Unraveling the mechanism by which IL-1b-inducing pathobionts promote disease will provide critical new insight into our current understanding of the pathogenesis of CD as well as aid the development of novel treatment options for CD.

PI_NAMEs: KAMADA, NOBUHIKO  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: adaptive immunity;Affect;B-Lymphocytes;Bacteria;Bone Marrow;Cells;Chronic;Colitis;Colon;Crohn's disease;cytokine;Development;dextran sulfate sodium induced colitis;Digestive System Disorders;Disease;Epigenetic Process;Epithelial Cells;epithelial injury;Epithelium;experimental study;Genetic Transcription;Goals;gut colonization;gut inflammation;gut microbiota;Immune;Immunity;imprint;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;innovation;insight;Intestines;Leaky Gut;Link;Macrophage;Mediating;member;Memory;Mononuclear;Mucous Membrane;Mus;Myeloid Cells;Myelopoiesis;Natural Immunity;neutrophil;novel;pathobiont;Pathogenesis;Pathogenicity;Patients;Persons;Phagocytes;Play;Population;Predisposition;Process;progenitor;Research;Role;Testing;Training;Ulcerative Colitis;United States

PROJECT_TITLE: The role of IL-1ß-inducing pathobionts in the pathogenesis of Crohn’s disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-Y(04)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

PHR: PROJECT NARRATIVE Juvenile justice-involved youth (JJIY) experience high rates of psychiatric disorders and trauma, yet low rates of mental health service receipt, all of which is associated with poor sleep. Though sleep promotion is associated with reduced psychopathology, there has not been a systematic study of the sleep of adolescents involved in the juvenile justice system, the correlates of sleep in this population, nor the options for implementing evidence- based sleep-focused treatments in various juvenile justice system settings. We propose a descriptive, mixed- methods study to 1) examine the nature and correlates of sleep among JJIY; 2) identify points of intervention in the juvenile justice system where sleep treatment can be delivered, personnel who can deliver it, and the resources needed to do so; and 3) identify strategies for effective translation and implementation of existing evidence-based sleep-focused interventions in system settings.

PI_NAMEs: LEVENSON, JESSICA C (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: actigraphy;Adolescence;Adolescent;Adult;adverse childhood events;adverse outcome;Age;Aggressive behavior;Behavior;Behavioral;Black race;Caregivers;Caring;Charge;Cognitive;Communities;Complex;Coupled;Cross-Sectional Studies;Data;data cleaning;Development;Diagnosis;diaries;Disease;Drops;emotion regulation;Emotional;Equity;Event;evidence base;experience;Family;Future;Health;Health Personnel;high risk;high school;Human Resources;implementation intervention;Imprisonment;Improve Access;improved;improvement on sleep;Impulsivity;inattention;Individual;Inequity;Intervention;Interview;Justice;juvenile justice system;Learning;Literature;low socioeconomic status;marginalization;marginalized population;member;Mental disorders;Mental Health;Mental Health Services;Methods;minority children;Moods;National Institute of Mental Health;Nature;novel;Outcome;Parents;Play;poor sleep;Population;probation;Professional counselor;programs;Protocols documentation;Provider;Psychopathology;Race;racial disparity;racial minority;racial minority population;racism;Regulation;Reporting;Research;Resources;Sampling;Services;skills;Sleep;Sleep Disorders;sleep pattern;sleep quality;sleep-focused interventions;Sleeplessness;social;Social Identification;Social Interaction;Strategic Planning;suicidal;Supervision;Surveys;System;Testing;Time;Training;Translating;Translations;Trauma;Underserved Population;United States;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Sleep among adolescents involved in the justice system

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The proposed study will examine midlife women's relationships and support exchanges with their late adolescent and adult children, as well as with other kin and non-kin, and the implications of these relationships and exchanges for women's psychosocial well-being. The experienced bi-national team will collect and analyze survey and in-depth interview data building upon an existing longitudinal panel of women in rural Mozambique, a setting that in many respects is typical of sub-Saharan Africa. The results of this study will fill important gaps in our understanding of intergenerational and community relationship dynamics and their consequences for women's welfare in rapidly changing resource-limited patriarchal contexts and will inform policies aimed at improving health and well-being of rural women and at optimizing health and social services for that vulnerable population segment.

PI_NAMEs: AGADJANIAN, VICTOR  (contact);HAYFORD, SARAH R

PROJECT_TERMS: Adolescent;Adult Children;Affect;Africa South of the Sahara;Aging;Anxiety;Characteristics;Child;child bearing;Child Rearing;Collaborations;Collection;Communities;Community Surveys;Coping Skills;Data;Data Collection;Databases;Decision Making;Economic Conditions;Economics;Education;Emotional;Employment;experience;Exposure to;Family;Gender;Generations;Happiness;Health;Health Services;Household;human old age (65+);Husband;improved;Income;interest;intergenerational;Interview;Investments;labor force participation;Labor Migrations;Laws;Life;Link;Low income;Marriage;Measures;member;men;Mental Depression;Mental Health;middle age;Midlife women;migration;Mozambique;multidisciplinary;Nutritional;Outcome;Parent-Child Relations;Parents;Participant;Pattern;Personal Satisfaction;physical conditioning;Physical shape;Policies;Process;Productivity;psychosocial outcome;psychosocial wellbeing;Recording of previous events;Reproduction;reproductive;Research;residence;Residential Mobility;Resources;Rural;Rural Community;rural families;rural setting;safety net;satisfaction;Scholarship;Security;Self Efficacy;Shapes;Site;skills;social;Social Change;Social Functioning;Social Interaction;social relationships;Social support;Social Work;socioeconomics;Standardization;stressor;Structure;Surveys;Time;transition to adulthood;Uncertainty;Variant;Vulnerable Populations;welfare;Woman;Women's Health

PROJECT_TITLE: Women’s Social Ties and Psychosocial Well-Being in a Resource-Limited Patriarchal Setting: A Longitudinal Perspective


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Services;Pain Research;Palliative Care;Patient Safety

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE The candidate’s long-term career objective is to make a sustained impact as a geriatric palliative care research leader by mentoring promising, multidisciplinary investigators in aging research. The candidate will accomplish this by: 1. expanding her current research program in a way that creates new and innovative opportunities for mentees to improve the care and quality of life of nursing home residents approaching the end of life, and 2. enhancing her skills and capacity to effectively mentor multidisciplinary mentees in patient-oriented research.

PI_NAMEs: TJIA, JENNIFER  (contact)

PROJECT_TERMS: Address;Admission activity;Adverse event;Affect;Aging;American;American Cancer Society;Analgesics;anti-depressive agents;Antibiotics;Anticoagulants;Anxiety;Area;Attention;Benefits and Risks;care delivery;career;career development;Caring;Certification;Cessation of life;Characteristics;Clinical;clinical candidate;clinical center;Clinical Research;Clinical Sciences;clinically relevant;cost;Data;Data Reporting;data resource;Data Set;Dedications;Dementia;design;Development;Discipline;Diuretics;Elderly;end of life;evidence base;experience;Explosion;Foundations;Frail Elderly;Fraud;Funding;Geography;Geriatrics;Goals;graduate school;Growth;Health system;Hospice Care;hospice environment;hospice utilization;hypnotic;improved;Individual;informant;innovation;Institute of Medicine (U.S.);Institutionalization;Interview;Length of Stay;Life;Life Expectancy;Link;Marketing;Massachusetts;Measures;medical schools;Medicare;meetings;Mentors;Mentorship;Methods;Modeling;multidisciplinary;Nursing Homes;Pain Measurement;palliative;Palliative Care;Palliative Medicine;patient oriented research;Patients;Pattern;payment;Performance;Pharmaceutical Preparations;Pharmacoepidemiology;Physician Executives;Play;Policies;Polypharmacy;Population;population based;population health;Prognosis;programs;Provider;Qualitative Methods;quality of death;Quality of life;Randomized, Controlled Trials;recruit;Reporting;Research;Research Activity;Research Personnel;Research Support;Resources;Risk;Role;Schools;Science;Services;Site;skills;Surveys;Symptom Burden;symptomatic improvement;Symptoms;therapy development;tool;Training;Training Support;Translational Research;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Longitudinal Patterns of Symptoms, Medication and Hospice Use in Nursing Home Residents Approaching End of Life

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Children with severe neurological impairment (SNI) make up 25% of intensive care (ICU) admissions and >50% of pediatric deaths in the ICU, translating to significant parental stress that is exacerbated by communication challenges during critical illness. This project will prospectively examine relationships between parent perceptions of health care communication and parent psychosocial outcomes during their child’s ICU admission, to then refine and pilot test a novel communication intervention to serve the unique needs of children with SNI and their families. Together, this project has the potential to improve parents’ ability to share their perspectives and needs regarding their child’s health and wellbeing during critical illness, in turn, improving parent and child outcomes.

PI_NAMEs: BOGETZ, JORI  (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: acceptability and feasibility;Admission activity;Adult;Advisory Committees;Area;arm;Behavior;career development;Caring;Cessation of life;Child;Child Advocacy;Child Care;Child Health;Childhood;Clinical;clinical care;Clinical Investigator;Clinical Trials;Clinical Trials Design;Communication;Communication difficulty;Critical Illness;Data;Decision Making;design;Empathy;Enrollment;Environment;experience;Family;Frequencies;Funding;Future;Goals;Grant;group intervention;Health;Healthcare;Hospitalization;Impairment;implementation intervention;improved;Intensive Care;Intensive Care Units;Intervention;intervention delivery;intervention refinement;Interview;K-Series Research Career Programs;Longitudinal cohort study;Measures;Mechanical ventilation;Medical;Mentors;Mentorship;Methods;multidisciplinary;Neurologic;novel;Outcome;Parents;Patients;Pediatric Intensive Care Units;Perception;Personal Satisfaction;perspective taking;pilot test;Population;post intervention;prospective;Prospective cohort;provider behavior;provider communication;psychosocial;psychosocial outcome;Publications;Qualitative Methods;Quality of life;Randomized;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;Recommendation;Reporting;Research;resilience;Rotation;skills;social stigma;stakeholder perspectives;Stress;Structure;success;Testing;Therapeutic;Therapeutic Intervention;therapy development;Time;Training;Translating;treatment as usual;United States National Institutes of Health;Well in self;Work

PROJECT_TITLE: A Novel Photo-Narrative Communication Intervention Among Parents of Children with Severe Neurological Impairment in the ICU

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE: Better understanding depression as a precursor to Alzheimer’s Disease (AD) is of significant public health impact. In this project we will integrate conceptual and technical innovations to measure tau, a key forms of AD pathology, in older adults with depression using both brain scans and blood tests, and determine how tau, depression, and memory and thinking function relate to each other over time to potentiate dementia risk. Findings from our study have the potential to make a near-term impact in clinical settings by changing the approaches we use to evaluate and manage depression in late life and prevent AD.

PI_NAMEs: GATCHEL, JENNIFER ROSE (contact)

PROJECT_TERMS: Address;Affective Symptoms;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Amyloid beta-42;behavioral and social science;Biological Markers;Blood Tests;Brain region;Brain scan;Clinical;clinical translation;Clinical Trials;clinically significant;Cognition;Cognitive;cohort;Data;dementia risk;depressive symptoms;design;Enrollment;Equation;Evaluation;Exclusion;follow-up;Funding;geriatric depression;Goals;Impaired cognition;innovation;Knowledge;late life;Major Depressive Disorder;Measurement;Measures;medial temporal lobe;Memory;Mental Depression;Modeling;N-terminal;neglect;Neurobehavioral Manifestations;neuropsychiatric symptom;novel;older adult;Participant;participant enrollment;Pathologic;Performance;PET positivity;Pittsburgh Compound-B;Plasma;Positioning Attribute;Positron-Emission Tomography;pre-clinical;prevent;Prevention;Public Health;Readiness;Research;Resolution;Risk;Severities;Site;social science research;spatiotemporal;tau Proteins;Temporal Lobe;Testing;therapy development;Thinking;Time

PROJECT_TITLE: Depression and Alzheimer's Disease:  CaTAUstrophy?

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Drug Abuse (NIDA only);Nutrition;Obesity;Prevention;Substance Misuse;Substance Misuse Prevention;Tobacco;Tobacco Smoke and Health

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Post-smoking cessation weight gain hinders quit attempts, precipitates relapse, and increases the risk of obesity and type 2 diabetes. This trial will examine a novel approach, a glucagon-like peptide-1 receptor agonist extended-release exenatide combined with nicotine patch, for facilitating smoking cessation and mitigating post-cessation weight gain. Availability of efficient gain mortality approaches to smoking cessation and post-cessation weight would encourage more smokers to quit and reduce the risk of relapse and premature morbidity and among those who quit.

PI_NAMEs: VERRICO, CHRISTOPHER D;YAMMINE, LUBA  (contact)

PROGRAM_OFFICER_NAME: HERRMANN, EVAN SULLIVAN

PROJECT_TERMS: Abstinence;Aftercare;Agonist;alcohol effect;American;Amphetamines;Attenuated;attenuation;Biochemical;Body Weight;Brain;Bupropion;Carbon Monoxide;Cause of Death;Cessation of life;Chronic Disease;Cigarette;cigarette smoke;cigarette smoking;Clinical;Cocaine;Combined Modality Therapy;Counseling;Cues;Data;Diabetes Mellitus;dietary;disability;Disease;Double-Blind Method;Double-blind trial;efficacy evaluation;emotional stimulus;Energy Intake;Enrollment;Ensure;Event;Event-Related Potentials;exenatide;exercise program;Food;Fright;GLP-I receptor;Goals;Health;Hyperglycemia;improved;Individual;innovation;Light;long term abstinence;Measures;Metabolic;Metabolic syndrome;Morbidity - disease rate;mortality;Nicotine;nicotine patch;nicotine replacement;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;obesity risk;Outcome Measure;Outcome Study;Overweight;Patient Self-Report;Persons;Pharmaceutical Preparations;Phase III Clinical Trials;Pilot Projects;placebo controlled study;Placebos;pre-clinical;preclinical study;Prediabetes syndrome;premature;Prevalence;primary outcome;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Relapse;relapse risk;Reporting;Research;Research Personnel;Resources;response;Rewards;Risk Factors;Risk Reduction;Sample Size;Scientist;Site;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;Smoking Prevention;Smoking treatment;Stimulus;Testing;Tobacco use;Tobacco Use Disorder;varenicline;Vulnerable Populations;Weight;Weight Gain;Woman;Work

PROJECT_TITLE: A Randomized Controlled Trial of Exenatide as an Adjunct to Nicotine Patch for Smoking Cessation and Prevention of Post-Cessation Weight Gain


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Quantitative assessment of progression through aging, based on reliable biomarkers, is critically important for both advancing the fundamental biology of aging and practical applications, such as testing interventions that extend lifespan. We propose to develop robust biomarkers of biological aging in mice and apply them to known and candidate longevity interventions. These biomarkers may be of wide use by the research community.

PI_NAMEs: GLADYSHEV, VADIM N.;HIGGINS-CHEN, ALBERT TZONGYANG (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Address;Age;age related;age related changes;Aging;aging biomarker;aging process;Animals;Basic Science;Behavior Therapy;Biological;biological age;Biological Aging;Biological Markers;Biology;Biology of Aging;Blood specimen;Caloric Restriction;Categories;Cell Aging;Cell Culture Techniques;Cells;Chronology;cohort;Communities;Consensus;Cultured Cells;Data;Development;dietary;dietary restriction;DNA Damage;DNA Methylation;epigenetic clock;Epigenetic Process;Exhibits;extend lifespan;Future;Gene Expression;Generations;Genetic;Geroscience;Goals;hallmarks of aging;Health;healthspan;Human;In Vitro;in vivo;Individual;Intervention;intervention effect;life span;Link;Longevity;Measures;Methylation;mimetics;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;molecular marker;Monitor;mortality;mouse model;Mus;novel;novel therapeutics;Organ;Organism;Outcome;pharmacologic;Phenotype;phenotypic data;Physiological;practical application;prognostic;quantification of aging;Reaction;Recommendation;Reporting;Research;Research Personnel;Resources;response;Sampling;screening;senescence;senescent cell;Series;Signal Transduction;System;Testing;Therapeutic;Time;Tissues;tool;Training;Validation

PROJECT_TITLE: QUANTITATIVE ASSESSMENT OF BIOLOGICAL AGE AND ITS APPLICATIONS

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE LatiNET will use a multilevel social network model to examine how SARS-CoV-2 misinformation and Conspiracy Theory (CT) messages are shared across five settings (friends, family, work, health service and influencers), impacting Latinx vaccine hesitancy. We will use Dr. Kanamori’s (PI) K99/R00 social network approaches and Drs. Uscinski’s and Stoler’s (Co-Is) misinformation and CT message framework to identify how network structures and dynamics introduce and spread SARS-CoV-2 misinformation and CT messages that could then influence Latinx vaccine hesitancy. We will also identify network structures and dynamics that promote discussion countering SARS-CoV-2 misinformation and CT messages.

PI_NAMEs: KANAMORI NISHIMURA, MARIANO JUAN (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: 2019-nCoV;Address;Adoption;Area;Behavior;Belief;Characteristics;cohesion;Communication;Communities;Contracts;County;COVID-19 misinformation;COVID-19 vaccine;cultural values;Decision Making;design;Discrimination;Disease;Dose;economic disparity;Economics;Emotional Bonds;experience;Family;Family member;Florida;Frequencies;Friends;Friendships;Fright;Future;Health;health disparity;health inequalities;Health Services;health services network;Hospitalization;Individual;Influentials;Intervention;intimate partner violence;Knowledge;Language;Latinx;Latinx population;Learning;Low income;Medical;member;Misinformation;National Institute on Minority Health and Health Disparities;network models;Network-based;pandemic disease;Participant;Pathway Analysis;Perception;Policies;Political Factor;Politics;poor communities;Population;Predisposition;pressure;psychologic;Psychological Factors;Public Health;recruit;SARS-CoV-2 negative;Science;self organization;service providers;Shapes;Site;social;social disparities;social factors;Social Network;social organization;social stigma;sociodemographics;Source;structural determinants;Structural Racism;Structure;Symptoms;System;Testing;theories;therapy design;Trust;unvaccinated;Vaccinated;Vaccination;vaccine hesitancy;Work

PROJECT_TITLE: LatiNET, a Multilevel Social Network Model to Examine and Address SARS-CoV-2 Misinformation in Low-Income Latinx Communities.


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Osteoporosis;Physical Injury - Accidents and Adverse Effects

ORG_CITY: Newton

ORG_NAME: BIOSENSICS, LLC

PHR: PROJECT NARRATIVE  Approximately 1 in 3 women and 1 in 5 men over the age of 50 will suffer from a fragility fracture in their remaining lifetime. Fragility hip fracture is one of the most serious and debilitating outcomes of osteoporosis with a 20–40% mortality rate during the first year after the fracture. Therefore, we propose to develop a cloud-based platform for automatic, opportunistic screening of X-ray image studies that will stand by in the central imaging data server of a hospital, investigate each non-investigated femur X-ray study, and flag the studies of patients that are detected to be at risk for a fragility fracture of the femur.

PI_NAMEs: NAZARIAN, ARA ;VAZIRI, ASHKAN  (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: Academic Medical Centers;Age;Alcohol consumption;Algorithms;American Medical Association;Architecture;Area;Artificial Intelligence;automated analysis;Biomechanics;Body mass index;bone;Bone Density;bone fragility;bone geometry;bone mass;Caring;Categories;Classification Scheme;Clinical;Clinics and Hospitals;cloud based;Cloud Service;Code;Collaborations;Computer software;cost;Country;Current Procedural Terminology;Current Procedural Terminology Codes;Data;Databases;Death Rate;density;design;Detection;Developed Countries;Development;Diagnostic;Disease;Dual-Energy X-Ray Absorptiometry;editorial;Endocrinology;Ethnic Origin;Evaluation;Face;Femoral Fractures;Femur;Fracture;fracture risk;fragility fracture;Geometry;Glucocorticoids;Health care facility;high risk;hip bone;Hip Fractures;Hip region structure;Hospitals;Image;image processing;Imaging Device;imaging study;Incidence;Income;indexing;Individual;insight;International;Intraobserver Variability;Ionizing radiation;Life Cycle Stages;Life Expectancy;Machine Learning;machine learning classification;Maintenance;Marketing;Measurement;Measures;Medical Device;Medical Imaging;medical schools;men;Metastatic Neoplasm to the Bone;Morocco;Orthopedics;Osteoporosis;Outcome;Parents;Patients;Persons;Phase;Pilot Projects;Preventive measure;Probability;Procedures;Process;Radiation;Radiation Dose Unit;radiological imaging;Radiology Specialty;Recording of previous events;Reporting;Research;Resolution;Rheumatoid Arthritis;Risk;Roentgen Rays;Rotation;screening;Secure;sex;Small Business Innovation Research Grant;Smoking;soft tissue;Specimen;Spinal Fractures;standard measure;Structure;System;Technology;Time;tool;Tube;tumor;Validation;Vertebral Bone;Visualization;voltage;Weight-Bearing state;Woman;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: Automatic, Opportunistic Surveillance of Hip Bone Fragility in X-ray Images


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE. Metabolic processes are involved directly or indirectly in essentially everything a cell does, there still remains much to learn regarding how proliferating cell metabolism is regulated. Pyruvate kinase M2 (PKM2) catalyzes the last step in glycolysis and determines whether cells can produce enough nucleotides to proliferate; its expression has been linked to a wide range of pathologies including cancer, heart failure, neuroinflammation, and neuropathic pain. This proposal will develop novel radiotracers targeting PKM2 that will enable an innovative method of imaging a hallmark of metabolism and has potential to improve our understanding of metabolic adaptations in multiple disease states.

PI_NAMEs: BEINAT, CORINNE  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: absorption;Adopted;Binding;Biodistribution;Biological Models;Blood - brain barrier anatomy;blood glucose regulation;Brain;Cardiovascular system;Cell Culture Techniques;Cell division;Cell Physiology;Cell Proliferation;Cells;Cellular Metabolic Process;clinical candidate;Clinical Research;clinical translation;clinically relevant;Data;Development;Disease;Dose;Enzymes;Evaluation;first-in-human;Fluorine;Formulation;Gallbladder;Generations;Glioblastoma;Glucose;glucose metabolism;glucose transport;Glycolysis;Goals;healthy volunteer;Heart failure;Human;human model;human study;human subject;Image;imaging modality;Impairment;improved;in vivo;innovation;intravenous administration;knock-down;Learning;Link;lipophilicity;Malignant Neoplasms;Mediating;Mediator;Metabolic;Metabolism;Modeling;molecular imaging;Mus;Myocardial dysfunction;Myocardium;neuroinflammation;Neurologic;non-invasive imaging;Normal tissue morphology;novel;Nucleotides;painful neuropathy;Pathologic;Pathology;patient population;Patients;Penetration;pharmacologic;Phosphorylation;Play;Positron-Emission Tomography;preclinical study;Primary Brain Neoplasms;Proliferating;Property;Protein Isoforms;Pyruvate Kinase;Quality Control;Radiation Dose Unit;Radiolabeled;Radiometry;Radiopharmaceuticals;radiotracer;Reporting;Research;response;Rodent;Role;Scanning;Signal Transduction;Site;Small Interfering RNA;small molecule;Solubility;Specificity;Structure;success;Technology;Testing;tissue regeneration;Translating;Translations;uptake;Visualization;white matter;Work

PROJECT_TITLE: Molecular Imaging of Pyruvate Kinase M2

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Learning and decision making are driven by expectations of future outcomes, yet how outcome prediction is generated by the brain to learn and inform behavior is poorly understood. We propose to investigate this issue by using a model system for the study of reinforcement-based learning—the visual corticostriatal circuit—which affords control over inputs predictive of future outcomes, as well as inputs conveying the occurrence, magnitude, and valence of outcomes themselves. The goals of the work are to: 1) characterize corticostriatal signaling of outcome prediction and the circuitry producing it, 2) measure cholinergic and dopaminergic signaling of rewards and punishments and establish how reinforcement signaling teaches corticostriatal circuitry to report outcome prediction, and 3) demonstrate that this outcome prediction signal causally informs decision making.

PI_NAMEs: SHULER, MARSHALL GILMER (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Address;Affect;Animals;area striata;basal forebrain;Behavior;Behavioral;Biological Models;Brain;Choice Behavior;cholinergic;Cholinergic Fibers;Cognition Disorders;Computer Models;conditioning;Corpus striatum structure;Cues;Data;Decision Making;Desire for food;Dimensions;Dopamine;Dorsal;Educational process of instructing;Electrophysiology (science);Elements;Event;expectation;experience;Fiber;Future;Goals;Human;Image;Impairment;Learning;learning outcome;Measures;member;Modeling;Motor;nerve supply;neural;neural circuit;Neuromodulator;Neurons;neuroregulation;Operant Conditioning;optical sensor;optogenetics;Outcome;outcome prediction;Production;Psychological reinforcement;Punishment;Reporting;Research;response;reward expectancy;Rewards;Role;Sensory;Signal Transduction;Site;Source;System;Testing;theories;Time;Visual;Visual Cortex;visual learning;visual stimulus;Water;Work

PROJECT_TITLE: The production, learning, and behavioral significance of outcome prediction signaling in the corticostriatal circuit

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences;Rare Diseases;Rehabilitation

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative Millions of Americans with speech disorders of various etiologies receive speech pathology services, but the efficacy of therapy is limited by an incomplete understanding of the brain mechanisms involved in speech sequence learning. Results from the proposed research will provide fundamental knowledge as to how speakers learn to produce new speech sequences that is ultimately necessary to provide more effective assessment and therapy for individuals with speech disorders.

PI_NAMEs: MILLER, HILARY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Accounting;Adverse event;American;Apraxia;Area;Articulation Disorders;Articulators;behavior prediction;Behavioral;Brain;Brain region;Buffers;career;Categories;Cell Nucleus;cerebral atrophy;Cerebral cortex;Clinical;clinical diagnosis;Clinical Treatment;Communication;Communication impairment;Digit structure;Disease;Dissociation;Economics;Etiology;Exhibits;Impairment;improved;Individual;inferior frontal sulcus;interest;Intervention;Knowledge;Language;language impairment;Learning;learning ability;Left;Length;Life;Location;Maps;Measures;Methods;Mission;Modeling;Motion;Motor;Motor Cortex;motor learning;Movement;MRI Scans;National Institute on Deafness and Other Communication Disorders;Nerve Degeneration;Nervous System Disorder;neural;neural correlate;Neurodegenerative Disorders;neuroimaging;non-Native;novel;Participant;Patients;Pattern;Performance;phonology;Population;preservation;Primary Progressive Aphasia;Process;Production;programs;Progressive Aphasias;psychosocial;rehabilitation service;Rehabilitation therapy;Research;Role;sequence learning;Services;Short-Term Memory;Site;sound;Specific qualifier value;Speech;speech accuracy;Speech Disorders;Speech Pathology;Speech Sound;Speech Therapy;Speed;Structure;System;Testing;Thick;Thinness;Training;Treatment Efficacy;Variant;Work

PROJECT_TITLE: Predictors of Speech Motor Sequence Learning in Neurological Disorders


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative In our everyday lives, we frequently encounter situations we have never previously faced and yet are required to make an appropriate response on the first try. This ability to rapidly and flexibly ‘self-program’ is one of the hallmark features of human intelligence. The proposed studies leverage exciting new developments in neuroscience, neurosurgery, engineering, and artificial intelligence to understand the neuronal circuitry underlying this amazing capacity.

PI_NAMEs: SHETH, SAMEER ANIL (contact)

PROGRAM_OFFICER_NAME: GEBREHIWET, HERMON RUSSOM

PROJECT_TERMS: Acute;Address;Algorithms;Amaze;Anterior;Artificial Intelligence;Behavior;Behavioral;Brain;cell cortex;Cells;Chronic;Cinnamon - dietary;Cognitive;cognitive neuroscience;cohort;Complex;computational basis;Computer Models;Data;design;Development;Devices;Elements;Engineering;entorhinal cortex;Environment;Epilepsy;Etiology;experience;flexibility;Frequencies;Functional Magnetic Resonance Imaging;Goals;Hippocampus;Human;Implant;Individual;innovation;Inpatients;Instruction;Intelligence;Link;Location;Maps;Medial;medial temporal lobe;mental representation;Modeling;Monitor;neural;neuronal circuitry;Neurons;neurophysiology;Neurosciences;Neurosciences Research;neurosurgery;novel;operation;Participant;Patients;Pattern;physical state;Population;predictive modeling;Prefrontal Cortex;programs;Property;Psyche structure;rehearsal;Reporting;Research;response;Rodent;Role;Series;Signal Transduction;Structure;Task Performances;Telemetry;Testing;Time;Variant;virtual reality;virtual reality environment;way finding;Work

PROJECT_TITLE: Mapping Algorithmic State Space in the Human Brain


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE Children who are HIV-exposed but uninfected in sub-Saharan Africa are an important, vulnerable population that survive the early years but often do not thrive. We will evaluate the impact of duration of HIV exposure in utero, immune status at birth and the psychosocial environment on neurocognitive development in children who are HIV-exposed but uninfected. This study will provide detailed evidence to identify the highest risk children within this group and to guide the future development of interventions to improve the well-being of children who are HIV-exposed in sub-Saharan Africa and throughout the world.

PI_NAMEs: GLADSTONE, MELISSA ;LAUFER, MIRIAM K. (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: 2 year old;5 year old;adaptive immunity;Address;Africa South of the Sahara;Age Months;antenatal;antiretroviral therapy;Biological Factors;Birth;Blood specimen;Caring;Categories;Cells;Child;Child Development;Child Health;Child Welfare;Childhood;Clinical Research;cohort;Communicable Diseases;Conceptions;Data;Development;Domestic Violence;effective intervention;Enrollment;Environment;Environmental Risk Factor;Evaluation;experience;experimental study;Exposure to;Family;Flow Cytometry;follow-up;Future;Goals;Health;high risk;HIV;HIV Antigens;HIV Infections;HIV-exposed uninfected infant;Home environment;immune activation;immunological status;Immunologics;Immunologist;Impairment;Improve Access;improved;in utero;Infant;Infection;Inflammation;Interdisciplinary Study;Intervention;Lead;Life;Link;Long-Term Effects;Malawi;maternal depression;maternal stress;Measures;Mental Depression;Mental Health;Methods;monocyte;Mononuclear;Mother-Child Relations;Mothers;Neonatal;Neurocognitive;Neurocognitive Deficit;Neurological outcome;Outcome Assessment;pediatrician;Personal Satisfaction;Population;postnatal;Pregnancy;Pregnant Women;prenatal exposure;Prior Therapy;psychosocial;Psychosocial Assessment and Care;Psychosocial Factor;psychosocial stressors;Resource-limited setting;Risk;Sample Size;Scientist;screening;social;social stigma;Social support;Socioeconomic Factors;Socioeconomic Status;Specialist;Standardization;T-Lymphocyte;therapy development;Treatment/Psychosocial Effects;Umbilical Cord Blood;Vertical Transmission;Viral Load result;Viremia;Visit;Vulnerable Populations;Woman;women's diagnosis

PROJECT_TITLE: Neurocognitive development of HIV-exposed and uninfected infants in Malawi

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Neurosciences;Opioids

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE The primary cause of death from an opioid overdose is respiratory depression. Opioid-induced sedation further impairs respiration through largely unexplored mechanisms. The outcomes of this project will provide fundamental insights into the neurobiological control of respiration, the influence of opioids, and will possibly identify new strategies to alleviate respiratory depression and stimulate breathing.

PI_NAMEs: VARGA, ADRIENN GABRIELLA (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Address;Animals;Arousal;awake;Award;Brain;brain control;Brain Stem;Breathing;career;Career Choice;career development;Cause of Death;Cell Nucleus;cell type;Cells;combat;Coupled;Data;Depressed mood;design;Development;Electrophysiology (science);experience;Fiber;Foundations;Frequencies;Glutamates;Goals;Image;Impairment;in vivo;Individual;insight;Knowledge;locus ceruleus structure;Mediator;Mentors;Mentorship;Methodology;Methods;Modeling;Monitor;Mus;Naloxone;neural;neural circuit;Neurobiology;neurochemistry;neuromechanism;Neurons;neurophysiology;Neurosciences;noradrenergic;Norepinephrine;novel;Opioid;Opioid Antagonist;opioid mortality;opioid overdose;Opsin;optogenetics;Outcome;Overdose;Pain;Pathway interactions;Pharmacology;Phase;Photometry;Play;Population;postsynaptic;presynaptic;professor;programs;Research;research and development;Research Personnel;Respiration;respiratory;Respiratory physiology;Role;Sedation procedure;sedative;Sensory;side effect;Slice;Solid;Source;Structure;Synapses;Technical Expertise;Techniques;Testing;therapeutic target;Training;Ventilatory Depression;virus genetics;voltage clamp;Wakefulness;Withdrawal

PROJECT_TITLE: Role of an arousal circuit in respiration and opioid-induced respiratory depression

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Simulation is a promising solution to improve the technical skills of obstetricians for managing postpartum hemorrhage (PPH), a rare but potentially life-threatening birth complication that disproportionately impacts underserved women in the U.S. We propose a staged, multicenter study to trial three innovations to overcome common obstacles to widespread implementation: a novel, affordable medium-fidelity simulator; remote synchronous mentoring; and asynchronous mentoring. If successful, results will inform best practices, advance education and training standards, and enable nationwide dissemination, including in low-resource settings. 1

PI_NAMEs: ADELMAN, JASON STUART (contact);GOFFMAN, DENA

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Academic Medical Centers;Address;Adoption;Area;care outcomes;care providers;Caring;Cesarean section;Clinical;clinical decision-making;Communication;Community Hospitals;Competence;cost;Country;Dedications;delivery complications;Discipline of obstetrics;Disparity;Effectiveness;effectiveness evaluation;Emergency Situation;ethnic minority population;Ethnic Origin;Exposure to;flexibility;Funding Opportunities;health disparity;Hemorrhage;Hospitals;Human Resources;implementation barriers;improved;improved outcome;Incidence;innovation;Intervention;Life;Location;Low income;maternal morbidity;Maternal Mortality;Measures;Medical;Medical Education;Mentors;Methods;Minority Groups;Morbidity - disease rate;mortality;Multicenter Studies;novel;obstetrical complication;Operative Surgical Procedures;Outcome Assessment;Participant;Patient Care;patient population;patient safety;Persons;Population;Postpartum Hemorrhage;preventable death;primary outcome;programs;Protocols documentation;Race;racial minority population;racial minority women;Readiness;Research;Residencies;Resource-limited setting;response;Risk;Risk Reduction;Rural Hospitals;Schedule;severe maternal morbidity;simulation;skill acquisition;skills;Socioeconomic Status;Standardization;Surgical Specialties;Surgical sutures;Teaching Method;Technical Expertise;Techniques;technology development;Time;Training;Training and Education;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Simulation for Attending Obstetricians to Improve Technical Skills for Managing Postpartum Hemorrhage

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]