NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Glioblastoma (GBM), the most common primary brain tumor in adults, is a highly invasive, neurologically destructive tumor with a survival range of 12-15 months despite maximum treatment efforts. A central issue contributing to treatment failure is the heterogeneous or varied cell type composition of these tumors. This proposal will identify mechanisms that promote a mesenchymal tumor state, synonymous with therapy resistance. We will pharmacologically target this state to improve therapeutic efficacy of known agents for patients with newly diagnosed and recurrent GBM.

PI_NAMEs: FURNARI, FRANK  (contact);MILLER, CHRISTOPHER RYAN

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Acetylation;Adult;Attention;Attenuated;Autoimmune Diseases;Automobile Driving;avatar models;Binding;Binding Proteins;BRD2 gene;Bromodomain;Bromodomains and extra-terminal domain inhibitor;Cancer Model;cell type;Cells;Client;clinically relevant;Combined Modality Therapy;Complement;Complex;constitutive active receptor;Data;Development;Disease;disease model;Drug Targeting;Epidermal Growth Factor Receptor;epidermal growth factor receptor VIII;epigenomics;Excision;Exhibits;Extracellular Domain;Family;Family member;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Glioblastoma;Glioma;Goals;Heterogeneity;Histones;Human;human induced pluripotent stem cells;Immune Evasion;improved;In Vitro;in vivo;Individual;Inflammatory;Inflammatory Response;inhibitor;interest;irradiation;Knock-in;knockout gene;Lysine;Macrophage;Malignant Neoplasms;Mediating;Mediator;member;Mesenchymal;Mesenchymal Cell Neoplasm;Methods;Microglia;Modeling;molecular subtypes;Mus;mutant;Mutation;Nature;neuro-oncology;Neurologic;Neurosphere;Newly Diagnosed;NF-kappa B;Nuclear;Operative Surgical Procedures;p65;Pathway interactions;Patient Agents;patient derived xenograft model;Patients;Phagocytes;Pharmaceutical Preparations;pharmacologic;Phenocopy;Phenotype;PIK3CG gene;Post-Translational Modification Site;Post-Translational Protein Processing;pre-clinical;Precision therapeutics;Primary Brain Neoplasms;Prognosis;programs;protein activation;protein complex;protein degradation;Proteins;PTEN gene;Radiation;Radiation therapy;Radiation-Sensitizing Agents;radioresistant;recruit;Recurrence;Regulation;Reporter;Resistance;Role;Signal Transduction;Site-Directed Mutagenesis;standard of care;temozolomide;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;therapy resistant;transcription factor;Transcriptional Activation;transcriptome;transcriptomics;Treatment Efficacy;Treatment Failure;tumor;tumor heterogeneity;tumor microenvironment;Work

PROJECT_TITLE: Therapeutic targeting mesenchymal transition in newly diagnosed and recurrent GBM


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative: Transesophageal echocardiography (TEE) is an essential diagnostic tool in the assessment of heart structure and function. TEE requires the use of sedation. Sedation requires specialized procedural space and skilled providers, which increases procedural cost, burdens the workflow, increases the risk to the patient, and overall limits the availability of TEE. Sedation accounts for the majority of the harm associated with TEE including cardiovascular (hypotension, arrythmia) and respiratory compromise. We are designing, building, and testing a novel trans-nasal TEE system that requires no anesthesia, which ultimately will improve safety, reduce cost, and will expand availability.

PI_NAMEs: TUMARKIN, ETHAN  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Acute;Adult;Aging;Anesthesia procedures;Anterior nares;auricular appendage;Blood Pressure;Blood Vessels;Burn injury;Cardiac;Cardiology;Cardiovascular Surgical Procedures;Cardiovascular system;Caring;Chest;Chest imaging;Childhood;Clinical;comorbidity;cost;Critical Illness;cryptogenic stroke;Dedications;design,build,test;Development;Devices;Diagnosis;Diagnostic Imaging;diagnostic tool;Diameter;Echocardiography;Endocarditis;Engineering;Esophagus;Event;Exercise;Goals;Heart;heart imaging;Heart Valves;Hemorrhage;High Prevalence;Hospitalization;Hypotension;Image;imaging modality;imaging platform;improved;Infection;Injury;innovation;Left;Lung;Methods;Mitral Valve;Mitral Valve Insufficiency;Morphologic artifacts;Nasal cavity;Nose;novel;Oral;Oropharyngeal;Patients;procedure cost;Procedures;programs;prototype;Provider;Reporting;Resolution;respiratory;Risk;Risk Reduction;Safety;Sedation procedure;Severities;skills;Structure;System;Technology;Thrombus;Time;tool;Transesophageal Echocardiography;Trauma patient;Tube;ultrasound;United States

PROJECT_TITLE: Trans Nasal Transesophageal Echocardiography

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M2)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PI_NAMEs: GALLI, STEPHEN JOSEPH (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: DETROIT

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Infectious endophthalmitis remains a frightening complication after eye surgeries, which often results in blindness, or in severe cases, enucleation of the eye. Unfortunately, few clinical tests can differentiate infectious endophthalmitis from non-infectious, making it challenging to identify patients which can delay proper treatment with the appropriate antimicrobial therapy to prevent vision loss. Here, we will integrate cutting-edge metabolomics technology and a machine-learning bioinformatic approach to identify vitreous metabolic signatures to aid in potential clinical diagnosis and study the pathobiology of ocular infections.

PI_NAMEs: KUMAR, ASHOK  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acceleration;Animal Model;Animals;Antibiotics;Antifungal Therapy;antimicrobial;Artificial Intelligence;artificial intelligence model;Asian Indian;bacterial endophthalmitis;bench to bedside;Bilateral;biobank;Biochemical;Biocompatible Materials;Bioinformatics;Biological;Biological Markers;Blindness;Cell Physiology;Cells;Citric Acid Cycle;Clinic;Clinical;clinical diagnosis;Clinical Research;cohort;Collaborations;Complement;Complication;Country;cytokine;Data;Diabetic Retinopathy;Diagnosis;Diagnostic;diagnostic strategy;Disease;Early Diagnosis;Endophthalmitis;Enzymes;Epiretinal Membrane;Etiology;Experimental Models;experimental study;Eye;Eye diseases;Eye Enucleation;Eye Infections;fungus;Future;Genes;Genus staphylococcus;Glaucoma;Global Change;Goals;Gram-Negative Bacteria;Gram-Positive Bacteria;high throughput technology;Human;human disease;human model;Incidence;India;Individual;Infection;Inflammation;Inflammatory;insight;Knowledge;Link;Liquid substance;Machine Learning;Macular Hole;Metabolic;metabolic abnormality assessment;metabolic profile;Metabolism;metabolomics;microbial;microorganism;Modeling;Molecular Weight;Mus;Natural Immunity;novel;Operative Surgical Procedures;Ophthalmologic Surgical Procedures;pathogen;Pathogenesis;Pathologic;Patients;Penetrating Eye Injuries;Phase;Phenotype;Physiological;Pilot Projects;Population;potential biomarker;precision medicine;predictive modeling;prevent;Prevention;profiles in patients;Protein Analysis;Publications;Publishing;Recurrence;Research;Retinal Diseases;Role;Sampling;Science;Sensitivity and Specificity;Signal Transduction;Site;small molecule;Technology;Testing;Therapeutic;therapeutic target;Tissues;transcriptomics;translation to humans;translational potential;Uveitis;Validation;Vision

PROJECT_TITLE: Vitreous metabolic perturbations during bacterial and fungal endophthalmitis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Services;Mental Health;Neurosciences;Opioids;Pain Research;Pediatric;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Pain is common in children presenting to the emergency department but is frequently undertreated, leading to both short- and long-term consequences. Morphine is the standard treatment for children with moderate to severe acute pain, but its use is associated with serious side effects and caregiver and clinician concerns related to opioid administration. Our research aims to demonstrate that sub-dissociative ketamine is as effective as morphine and a preferable alternative for treating acute pain in children because of its more favorable side effect profile and potential long-term benefits related to pain-related function, analgesic use/misuse, and mental and behavioral health outcomes.

PI_NAMEs: DRENDEL, AMY L;TSZE, DANIEL SING-KWONG (contact)

PROGRAM_OFFICER_NAME: TAYLOR-ZAPATA, PERDITA

PROJECT_TERMS: 17 year old;Abdominal Pain;Absence of pain sensation;Accident and Emergency department;Acute;Acute Abdomen;Acute Pain;Acute pain management;Adult;Adverse event;Analgesics;antagonist;Anxiety;Applied Research;behavioral health;behavioral outcome;Cardiopulmonary;Caregivers;central sensitization;Child;chronic pain;Dependence;Dose;efficacy evaluation;Emergency Care;Emergency department visit;endogenous cannabinoid system;Enrollment;Event;experience;Family;follow-up;Fracture;Fright;Goals;Guidelines;Health;Hour;Hyperalgesia;Hypotension;improved;indexing;Interruption;Intravenous;Ketamine;Knowledge;Limb structure;long-term sequelae;Medical;Mental Depression;Mental Health;Modality;Morphine;N-Methylaspartate;non-opioid analgesic;Opioid;opioid epidemic;opioid misuse;Outcome;Pain;Pain intensity;Pain management;Pain Measurement;pain reduction;parenteral administration;Pathway interactions;Patient-Focused Outcomes;pediatric emergency;Pharmaceutical Preparations;Phase;post-traumatic stress;Post-Traumatic Stress Disorders;Pre-hospital setting;Procedures;randomized, clinical trials;Research;Safety;sedative;side effect;Site;standard care;Symptoms;Trauma;Ventilatory Depression

PROJECT_TITLE: Efficacy of intravenous sub-dissociative ketamine versus intravenous morphine in children with acute pain.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-N (51)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: AMHERST

ORG_DEPT: DENTISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: NARRATIVE  During animal development, epithelial stem and progenitor cells of the salivary gland undergo a number of dynamic processes of maturation and differentiation, which require the coordinated action of cell-type specific transcription factors such as p63. We propose to use knockout mouse models and genomic tools to better elucidate the functional role of p63 and to identify crucial signaling pathways in salivary gland organogenesis and regeneration. Such studies will provide fundamental mechanistic insights into cellular processes of salivary gland during injury, repair and in diseased states.

PI_NAMEs: ROMANO, ROSE-ANNE  (contact);SINHA, SATRAJIT

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Activins;Address;Adult;Animals;Automobile Driving;Biological Models;Biology;Cell Differentiation process;Cell Fate Control;cell fate specification;Cell Lineage;Cell Physiology;cell type;Cells;Chromatin;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;cofactor;Development;Disease;Duct (organ) structure;Embryo;Embryonic Development;Environment;Enzymes;Epigenetic Process;epigenomic profiling;epigenomics;Epithelial Cells;epithelial stem cell;Epithelium;experimental study;Family;follow-up;Functional disorder;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;genetic approach;Genetic Transcription;Genomic approach;genomic data;genomic tools;Genomics;Gland;gland development;Goals;Growth Factor;Heparin Binding Growth Factor;Homeostasis;Human;in vivo;injured;Injury;innovation;insight;Knockout Mice;Knowledge;Ligation;Maintenance;member;midkine;Molecular;Morphogenesis;mouse model;Mus;Myoepithelial;Natural regeneration;novel;novel therapeutic intervention;Organogenesis;Outcome;Patients;Play;pleiotrophin;Population;precursor cell;Process;programs;Proliferating;Protein Isoforms;Proteins;Proteomics;Radiation Tolerance;radiation-induced injury;Recovery;Regulation;Regulatory Element;repaired;Resolution;response to injury;Role;Salivary;Salivary Gland Tissue;Salivary Glands;self-renewal;Shapes;Signal Pathway;Signal Transduction;Signaling Protein;single cell genomics;single-cell RNA sequencing;spatiotemporal;stem;stem cell differentiation;stem cell population;stem cells;stemness;Submandibular gland;Techniques;Technology;Testing;Therapeutic Intervention;tissue regeneration;tissue repair;Tissues;transcription factor;transcriptomics;Transforming Growth Factor beta;Work

PROJECT_TITLE: Regulatory mechanisms that dictate stem and differentiated cell populations of the salivary gland

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Genetics;Human Genome;Mental Health

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The project aims to develop methods and tools and conduct collaborative research for the integrative analysis of data generated by the Developmental Genotype-Tissue Expression (dGTEx) initiative, non-human primate (NHP) dGTEx project, existing GTEx project, and other studies. Aim 1 will develop integrative methods for mapping expression quantitative trait loci (eQTLs), utilizing multi-view learning techniques for detecting various types of QTLs; Aim 2 will develop a series of multi-age-group multi-tissue/cell Mendelian randomization methods to identify risk genes in a variety of applications; and Aim 3 will conduct collaborative dGTEx data analysis and develop software. We will leverage our expertise gained from the GTEx consortium, and will collaborate with the Steering Committee to ensure the timely dissemination of rigorous dGTEx results.

PI_NAMEs: CHEN, LIN  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Accounting;Adolescent;Adopted;Adult;Affect;Age;age group;Awareness;Catalogs;cell age;cell type;Cells;Child;Childhood;Collaborations;Communities;comparative;Complex;Computer software;Data;Data Analyses;Data Set;Data Sources;Detection;detection method;Development;Developmental Gene;Disease;disorder risk;DNA Methylation;Ensure;experience;flexibility;Foundations;frontier;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;genetic variant;Genetic Variation;genome wide association study;Genomics;Genotype;Genotype-Tissue Expression Project;Healthcare;Human;Human Development;human tissue;improved;insight;Learning;learning strategy;Link;Machine Learning;Maps;Medicine;Mendelian randomization;Methods;methylome;Modeling;Molecular;multiple omics;neonate;nonhuman primate;novel;Output;Pattern;Population;practical application;Probability;Quantitative Trait Loci;Regulation;Research;Research Project Grants;Risk Assessment;Risk Factors;risk variant;Series;Shapes;software development;statistics;Techniques;Tissue-Specific Gene Expression;Tissues;tool;trait;transcriptome;translational impact;translational potential;Work

PROJECT_TITLE: Integrative Analysis Methods for the dGTEx Initiative

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (M2)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: Chicago

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: The United States is an aging society where 1 in 3 healthy older adults experiences a fall every year, causing serious injuries and posing an enormous burden for the healthcare system; yet current fall prevention programs such as conventional balance training fail to reduce fall incidence, potentially due to their lack of task-specificity for acquiring fall resisting skills to recover from environmental falls. Over the past two decades, our work has established that repeated exposure to slip and trips in a safe environment can prevent falls up to 1 year after such training; however, such interventions are expensive, require complex technology, and are not readily scalable to clinics and community living facilities. In this study, we will provide cost-effective, safe and easy to translate task-specific balance exercises consisting of functional tasks and predictable perturbations targeted to reduce real-life falls.

PI_NAMEs: BHATT, TANVI  (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: acquired factor;Address;Adult;Adverse effects;Affect;Aging;Alzheimer's disease related dementia;Balance training;Cessation of life;Clinic;Clinical;clinical application;clinical translation;Communities;community living;community setting;comorbidity;Complex;cost;cost effective;Craniocerebral Trauma;design;Effectiveness;efficacy evaluation;Environment;Equilibrium;Equipment;Exercise;experience;Exposure to;Extensor;Fall prevention;fall risk;falls;Fright;Gait;healthcare burden;Healthcare Systems;high risk;Hip Fractures;Hospitalization;Impaired cognition;improved;Incidence;Injury;innovation;Intervention;Knowledge;Laboratories;Life;Limb structure;Long-Term Effects;Medical Care Costs;Methods;Muscle;Nature;neuromuscular;neuromuscular examination;novel;older adult;Persons;Physical Rehabilitation;Population;Prevention program;preventive intervention;Probability;programs;Progress Reports;Randomized;Recording of previous events;Risk;risk prediction model;simulation;skills;Societies;Specificity;Stroke;synergism;System;Techniques;Technology;Torque;Training;Training Programs;Translating;Translations;treadmill;United States;Walking;Work

PROJECT_TITLE: Aging and task-specific training to reduce falls

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: CA

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Immunotherapy;Microbiome;Networking and Information Technology R&D (NITRD);Prevention

ORG_NAME: GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY

PHR: Project Narrative The human microbiome is implicated in the development and response to treatment of some cancers, including infectious agents estimated to be responsible for ~20% of the global cancer burden. However, previously unrecognized bacterial and viral strains, as well as loss of normal structure and function of human-associated microbiomes, likely play additional roles in disease etiology and treatment. This project investigates the role of the human microbiome in cancer by applying novel and state-of-the-art methods to published metagenomic data, and provides enhanced, expanded, and more efficiently usable microbiome data resources back to the cancer research community for a broad range of investigations.

PI_NAMEs: WALDRON, LEVI  (contact)

PROGRAM_OFFICER_NAME: MAHABIR, SOMDAT

PROJECT_TERMS: Adopted;Adoption;anti-cancer research;Antibiotics;Architecture;automated analysis;Back;Bacterial Physiology;Cancer Burden;cancer risk;cancer therapy;cardiometabolism;cluster computing;Colorectal Cancer;Communities;comparative;Control Groups;cost effective;Data;data resource;Databases;Development;Diet;Disease;dysbiosis;Etiology;experience;FAIR principles;Funding;fungus;Genome;Head and Neck Cancer;Health;Heterogeneity;host microbiome;Human Microbiome;Immunology;Immunotherapy;improved;Individual;Infectious Agent;informatics infrastructure;Infrastructure;innovation;Internships;Intervention;Investigation;Knowledge;Knowledge Portal;knowledgebase;large-scale database;Link;Literature;Maintenance;Malignant Neoplasms;Manuals;Meta-Analysis;Metabolic;Metadata;Metagenomics;Methodology;Methods;Microbial Physiology;microbial signature;Microbiology;microbiome;microbiome research;microbiome signature;microbiota;microorganism;Modernization;Morphology;next generation;novel;Ontology;open data;open source;Oropharyngeal;Outcome;Output;Pharmaceutical Preparations;Physiology;Play;prevent;Process;programs;Proton Pump Inhibitors;public database;public health intervention;Publications;Publishing;Records;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resolution;Resources;response;Role;secondary analysis;Semantics;Sequence Read Archive;Shotgun Sequencing;Shotguns;Source;Standardization;Structure;summer research;System;Taxon;Taxonomy;tool;Training;treatment response;tumor progression;undergraduate research;undergraduate student;Underrepresented Populations;Update;usability;user-friendly;Viral;virome;web interface;web portal;wiki

PROJECT_TITLE: Exploiting Public Metagenomic Data to Uncover Cancer-Microbiome Relationships

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE Methods that allow scientists to engineer mammalian cells to execute desired cellular functions in response to defined biological and chemical signals offer tremendous potential for biomedical research and for creating next- generation cell-based biotechnologies and therapeutics. However, existing tools face significant limitations – for example, they do not offer clinically-suitable compositions, robust activity, and easy implementation across biomedically-relevant human cell types. To address these limitations, we propose to develop advanced synthetic biology tools to control gene regulation and cell function, and to apply these tools to engineer a variety of clinically-relevant human immune cell types, with broad applicability including potential therapeutic applications for cancer.

PI_NAMEs: KHALIL, AHMAD SAMIR (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Adaptive Immune System;Address;Adopted;Antigen Presentation;Behavior;Biological;Biology;Biomedical Research;Biotechnology;cancer cell;Cell Physiology;Cell Therapy;cell type;Cells;cellular engineering;Chemicals;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;clinically relevant;Communities;Complex;Custom;design;Development;Diagnostic;Digestion;engineered T cells;Engineering;Face;FDA approved;Fibrosis;first responder;frontier;Gene Expression Regulation;Genes;Genetic;Genetic Screening;Genetic Transcription;Goals;Human;Human Biology;Immune;immune activation;immune function;Immune response;immunoengineering;Immunosuppression;In Vitro;in vivo;Infiltration;Knowledge;Macrophage;Malignant Neoplasms;Mammalian Cell;Maps;Medicine;Metabolic Diseases;Methods;migration;monocyte;next generation;novel;Paracrine Communication;Phagocytes;Phagocytosis;Pharmaceutical Preparations;Play;Production;programs;Property;receptor;Reporter;Research Personnel;response;Role;Science;Scientist;signal processing;Signal Transduction;Solid Neoplasm;Standard Model;Structure;synthetic biology;Synthetic Genes;T-Lymphocyte;Technology;Therapeutic;Tissue Engineering;Tissues;tool;trafficking;transcription factor;tumor;tumor microenvironment;Work;wound healing

PROJECT_TITLE: Synthetic circuit technologies for precision control and signal processing in mammalian cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (80)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE We propose to develop chemically-modified, short interfering RNAs that accumulate in arthritic joints following systemic, carrier-free administration. The mechanism of action and therapeutic efficacy of this platform technology will be tested in models of osteoarthritis by applying it to silence genes that encode cartilage- degrading proteases and pro-inflammatory signaling pathways.

PI_NAMEs: DUVALL, CRAIG LEWIS (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Acceleration;Acetylgalactosamine;Address;Adrenal Cortex Hormones;Aging;Albumins;Amyloidosis;Animal Model;Anterior Cruciate Ligament;Architecture;Area;Arthralgia;Arthritis;bioinformatics pipeline;Biological Availability;Biology;Bone Spur;cadherin-11;Cartilage;Cavia;Cell membrane;cell type;Cells;Chemicals;Chemistry;Chondrocytes;Clinical;clinical care;clinically relevant;Collagen Type II;collagenase;collagenase 3;Complex;cytokine;Data;Degenerative Disorder;Degenerative polyarthritis;design;Deterioration;disability;Disease;Disease Progression;Docking;Drug Carriers;Drug Kinetics;efficacy testing;Extracellular Matrix;FDA approved;Financial Hardship;Formulation;Future;Gene Expression;Gene Silencing;Gene Targeting;Genes;Genetic;Genetic Medicine;Goals;guinea pig model;Healthcare Systems;Hepatocyte;Hyperplasia;Hypertrophy;improved;In Situ;In Vitro;Inflammation;Inflammatory;Injury;innovation;interest;International;Intra-Articular Injections;Intravenous;intravenous injection;joint injury;Joints;Knee;Lead;Length;Ligands;lipid nanoparticle;Lipids;Liver;Localized Disease;Longevity;longevity gene;manufacture;Matrix Metalloproteinases;Modeling;Modification;Molecular;mouse model;Mus;nanoparticle;Nature;new therapeutic target;Non-Steroidal Anti-Inflammatory Agents;normal aging;novel;nuclease;Pain;pain reduction;Pathogenesis;Penetration;Peptide Hydrolases;Pharmaceutical Preparations;Phenotype;Phylogenetic Analysis;physically handicapped;Polymers;Polyneuropathy;Probability;Process;receptor;Recommendation;Renal clearance function;Research;Resistance;Risk;RNA;RNA Interference;Scientist;Serum Albumin;side effect;Signal Pathway;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;Small Interfering RNA;small molecule;Societies;Steroids;Stomach;Structure;success;System;Technology;technology platform;Testing;Therapeutic;Therapeutic Effect;therapeutic gene;therapeutic RNA;therapeutic target;Thinness;Toxic effect;transcriptomics;Traumatic Arthropathy;Treatment Efficacy;United States;Work

PROJECT_TITLE: Carrier Free siRNA Conjugates as Disease Modifying Osteoarthritis Drugs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (81)]


NIH_SPENDING_CATS: Ataxia Telangiectasia;Cancer;Childhood Leukemia;Genetics;Hematology;Lymphatic Research;Lymphoma;Neurodegenerative;Pediatric;Pediatric Cancer;Primary Immunodeficiencies;Rare Diseases

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE  Our proposed study 1) how SLC7A11 deletion and ferroptosis prevent the transformation of Atm- deficient lymphocytes and other cancer cells; 2) how ATM promotes ferroptosis in T cells and in general; 3) whether T-ALLs and other ATM-deficient cancers are sensitive to ferroptosis inducers. The results will reveal the physiological functions of ATM in ROS responses and tumor suppression and identify new vulnerabilities of T-ALL and activating T cells with implications for cancer therapy and immuno-oncology application of ROS regulators.

PI_NAMEs: ZHA, SHAN  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acute T Cell Leukemia;Affect;Air;Alleles;Aneuploidy;antiporter;Ataxia Telangiectasia;ataxia telangiectasia mutated protein;Ataxia Telangiectasia Patients;ATM activation;ATM deficient;ATM function;ATM Gene Mutation;biological adaptation to stress;Blood;cancer cell;Cancer cell line;cancer therapy;Carcinoma;Catalysis;CD8B1 gene;Cell Death;Cells;Chromosomal translocation;Clinical Trials Design;cofactor;Complex;Coupled;Cysteine;Cystine;Data;Defect;Development;disulfide bond;DNA Damage;DNA Repair;Embryo;erastin;Frameshift Mutation;Funding;Genes;Genetic Transcription;Germ Lines;Glutamates;Glutathione;Human;Hydrogen Peroxide;Hypersensitivity;immunodeficiency;Immunooncology;In Vitro;in vivo;Inbreeding;inhibitor;Intake;Kinetics;lifetime risk;Link;Lipid Peroxidation;Loss of Heterozygosity;Lymphocyte;lymphoid organ;Lymphoma;Lymphoma cell;Lymphomagenesis;Malignant lymphoid neoplasm;Malignant Neoplasms;Membrane;Membrane Lipids;Missense Mutation;Modeling;mouse model;Mus;mutant;Mutate;Mutation;NBS1 gene;null mutation;Oxidative Stress;Oxygen;peroxidation;Phenotype;Phosphorylation;Phosphotransferases;Physiological;Polyunsaturated Fatty Acids;prevent;Reactive Oxygen Species;Reporting;response;Risk;Role;Rupture;selective expression;Site;Stress;System;T-Cell Activation;T-Cell Development;T-Cell Transformation;T-Lymphocyte;Testing;Thymic Lymphoma;tissue culture;TP53 gene;Tumor Expansion;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;Uterus

PROJECT_TITLE: The role of ATM in the suppression of lymphoid malignancy

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Recent studies have shown that mRNA can be dynamically regulated on specific adenosine residues to form N6-methyladenosine (m6A), an “epitranscriptomic” mark that occurs on a subset of mRNAs. m6A appears to be particularly important in cancer, where it controls diverse processes including cell fate and differentiation. With the development of novel inhibitors that target this pathway, we will uncover new dependencies to this program and characterize a new epitranscriptomic methylation mark on an adenosine residue in the mRNA encoding MYC, a key protein involved in cancer progression.

PI_NAMEs: JAFFREY, SAMIE R (contact);KHARAS, MICHAEL

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Ablation;Abnormal Cell;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adenosine;Adopted;Affect;Architecture;base editor;Biology;Blood;Cancer Biology;cancer cell;Cell Death Induction;Cell division;Cell Fate Control;Cells;Clinical Trials;Code;Complex;conditional knockout;Data;daughter cell;Defect;Dependence;Development;Enzymes;epitranscriptomics;Exhibits;Gene Expression;Gene Expression Regulation;Genetic Markers;genome-wide;Goals;Growth;Hematopoietic;hematopoietic differentiation;Hematopoietic stem cells;High Prevalence;inhibitor;innovation;Knock-out;Knockout Mice;Knowledge;Laboratories;leukemia;leukemogenesis;Link;Malignant Neoplasms;Maps;Mediating;Mediator;Messenger RNA;Metabolism;Methylation;Modification;Molecular;mouse model;mRNA Stability;Mutation;new technology;Normal Cell;novel;novel therapeutic intervention;Nuclear;Nuclear RNA;Nuclear Structure;Nucleotides;Oncogenes;Oncogenic;Pathway interactions;Patients;Pattern;Phenotype;Positioning Attribute;Post-Transcriptional Regulation;Prevalence;Process;programs;Proteins;Regulation;RNA;RNA methylation;Role;stem cell differentiation;stem cell division;stem cells;stoichiometry;Structure;technology development;Testing;Transcript;transcriptome;Translation Process;tumor progression;Undifferentiated;Work

PROJECT_TITLE: Mechanisms of epitranscriptomic regulation in cancer

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Residual cancer cells that survive therapy in early-stage breast cancer patients have the ability to survive in a dormant state following treatment and linger unrecognized for decades before resuming growth and re- emerging as lethal recurrent disease. Since recurrent breast cancers are typically incurable and arise from the reservoir of residual tumor cells that survive therapy, understanding the biology of minimal residual disease and elucidating the molecular pathways that contribute to tumor dormancy and recurrence is a critical priority in breast cancer research. This application is focused on that goal.

PI_NAMEs: CHODOSH, LEWIS A (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Acceleration;Address;Aftercare;anti-cancer research;Biological;Biology;Bone Marrow;Bone Marrow Aspiration;Breast Cancer Patient;breast cancer progression;Breast Cancer survivor;Breast Cancer Treatment;Cancer Etiology;Cancer Patient;cancer recurrence;cancer site;cancer subtypes;Cell Cycle;Cell Separation;Cell Survival;Cells;Cessation of life;chemotherapy;Clinical;clinical remission;clinically relevant;Companions;Development;Disabling;Disease;Distant;Down-Regulation;Event;Exhibits;fitness;Gene Expression;Gene Expression Profile;Genetically Engineered Mouse;Goals;Growth;Head and Neck Cancer;hormone therapy;Human;improved;in vivo;Lung;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mammary gland;Metastatic/Recurrent;Micrometastasis;Modeling;Molecular;mortality;Mus;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;novel;Oncogenes;Operative Surgical Procedures;Outcome;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;prevent;Primary Neoplasm;programs;Recurrence;recurrence prevention;Recurrent disease;Recurrent tumor;Refractory;Relapse;research clinical testing;Residual Cancers;Residual Neoplasm;Risk;Role;Sampling;SOX5 gene;Survival Rate;targeted treatment;therapeutic target;tumor;tumor progression;Tumor Promotion;tumorigenesis;Up-Regulation;Women's mortality;Xenograft Model

PROJECT_TITLE: In Vivo Oncogene-Induced Tumorigenesis and Escape

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: LA JOLLA

ORG_DEPT: MISCELLANEOUS

PHR: Project Narrative We propose an interdisciplinary research project to elucidate the mechanisms by which hemodynamic forces generated from blood flow causes endothelial RNA modifications to regulate blood vessel functions. The results generated from this study will provide novel information on vascular biology in health and disease (e.g. atherosclerosis). This study will also provide valuable knowledge for the improvement of treatment of cardiovascular diseases involving endothelial dysfunction.

PI_NAMEs: CHIEN, SHU ;SHYY, JOHN YJ (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: 6-Phosphofructo-2-kinase;Adhesions;Arterial Fatty Streak;atherogenesis;atheroprotective;Atherosclerosis;Base Sequence;Binding Proteins;Biology;Blood flow;Blood Vessels;Cardiovascular Diseases;Carotid Arteries;Cell Physiology;Coculture Techniques;crosslink;Data;Disease;DNA;Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;epitranscriptome;epitranscriptomics;Etiology;Eukaryota;Exhibits;Family;Fructose;Functional disorder;gain of function;Gene Expression;Genes;glucokinase regulatory protein;Glucose;glucose metabolism;Glycolysis;Glycolysis Inhibition;Health;hemodynamics;Human;Hypermethylation;Image;improved;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;insight;Interdisciplinary Study;knock-down;Knowledge;Label;Ligation;Link;Maps;marenostrin;Mediating;Messenger RNA;Metabolic;Methyltransferase;Microscopy;Modeling;Modification;monocyte;Mus;mutant;novel;overexpression;Pattern;Pentosephosphate Pathway;Phenotype;Proliferating;Reader;Regulation;Research;Research Project Grants;RNA;RNA Editing;Role;shear stress;Stenosis;System;Testing;Transaldolase;transcriptome;transcriptomics;translatome;Trees;Vascular Diseases;Visualization

PROJECT_TITLE: Shear stress Regulation of Endothelial Glycolysis via METTL3-mediated RNA m6A Modification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-N (90)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Narrative: Duchene muscular dystrophy is caused by mutations in the gene for dystrophin, which is highly expressed in muscle tissue, but also found at inhibitory synapses in the brain. The function of dystrophin in the brain is still unclear. This project will demonstrate that dystrophin, and the protein complex it belongs to, are necessary for maturation of inhibitory synapses. Understanding the function of dystrophin in synaptic function is critical to developing future therapies for cognitive deficits associated with muscular dystrophy and other neurodevelopmental disorders.

PI_NAMEs: PUGH, JASON RICHARD (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Acute;Adult;analytical tool;Anatomy;Attention deficit hyperactivity disorder;autism spectrum disorder;Binding;Brain;Brain region;Cell Adhesion Molecules;cell type;Cells;Central Nervous System;Cerebellum;Childhood;Cognitive deficits;Cognitive Therapy;comorbidity;Complex;critical developmental period;Critical Thinking;Data;design;Development;Developmental Delay Disorders;Disease;Duchenne muscular dystrophy;Dystrophin;Electron Microscopy;Electrophysiology (science);Etiology;experience;Functional disorder;Future;Genes;Genetic;Glycoproteins;Immunohistochemistry;Impairment;induced pluripotent stem cell;inducible Cre;Inhibitory Synapse;insight;Integral Membrane Protein;Knock-out;Knowledge;Maintenance;Measures;member;Morphology;Mus;Muscle;muscle degeneration;Muscular Atrophy;Muscular Dystrophies;Mutation;Myoepithelial cell;Neurodevelopmental Deficit;Neurodevelopmental Disorder;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phenotype;Play;Positioning Attribute;postsynaptic;presynaptic;prevent;Process;Property;protein complex;protein expression;Proteins;Purkinje Cells;Quantitative Reverse Transcriptase PCR;receptor;receptor function;Receptor Signaling;Regional Disease;Role;Signal Transduction;Symptoms;Synapses;synaptic function;synaptogenesis;System;Tamoxifen;Time;timeline;Vesicle;Wild Type Mouse;Work

PROJECT_TITLE: The Role of Dystrophin in Synapse Development

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: Project Narrative/Relevance Statement T cells are the cornerstone for immunotherapies for cancer and other diseases, but poor functional and proliferative capacity of cytotoxic T cells limit immunotherapeutic efficacy. We reveal transcriptional and metabolic pathways as novel regulators of T cell differentiation, heterogeneity and antitumor immunity, and a better understanding of these pathways using both candidate and screening approaches is essential for our efforts to develop next-generation immunotherapeutic strategies.

PI_NAMEs: CHI, HONGBO  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Adoptive Cell Transfers;Antigens;cancer immunotherapy;cancer therapy;causal variant;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cells;Cellular biology;Cellular Metabolic Process;chronic infection;Cleavage Under Targets and Release Using Nuclease;combinatorial;CRISPR screen;Cytokine Signaling;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Dependence;Disease;EGR2 gene;ETS1 gene;exhaust;Exhibits;experimental study;gain of function;Generations;Genes;Genetic;genetic manipulation;Genetic Transcription;Goals;Heterogeneity;Human;immune checkpoint blockade;Immunooncology;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Interleukin-10;Malignant Neoplasms;Mediating;Mediator;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Modality;Modeling;Molecular;Mus;next generation;novel;Pathway interactions;Patients;predictive modeling;Process;programs;response;Role;screening;Specificity;T cell differentiation;T-Lymphocyte;Testing;Therapeutic;transcription factor;Transcriptional Regulation;transcriptome;Treatment Efficacy;tumor;Tumor Immunity;tumor microenvironment;Validation

PROJECT_TITLE: Transcriptional and metabolic heterogeneity in T cell differentiation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Infectious Diseases;Lung

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

ORG_STATE: WA

PHR: Project Narrative The proposed research is relevant to the mission of the NIH because a better understanding of the mechanisms by which cells respond to damage and infection will contribute to treatment of inflammatory disorders and bacterial infections.

PI_NAMEs: LACY-HULBERT, ADAM  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Affect;airway epithelium;alpha Toxin;Applications Grants;Bacterial Infections;Biochemical;Cell Death;Cell Death Induction;cell injury;Cell membrane;Cell model;Cell Survival;Cells;Cellular biology;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;cytokine;Data;Defense Mechanisms;Disease;Endosomes;Epithelial Cells;Epithelium;Equilibrium;exosome;experimental study;Genes;Genetic Screening;Hemolysin;Homeostasis;Host Defense;human model;Immune;Immune signaling;Immunity;In Vitro;in vivo;in vivo Model;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Knockout Mice;Link;Lung;Lung infections;lung injury;Macrophage;MAP Kinase Gene;Mechanics;Mediating;Membrane;Membrane Proteins;Mission;Molecular;Molecular Biology;monocyte;mouse model;Mus;Mutagenesis;Mutation;Nutrient;pathogen;pathogenic bacteria;Pathologic;Pathology;Pathway interactions;Phagosomes;Play;prevent;Proteins;Publishing;Pulmonary Inflammation;Regulation;repaired;Research;Resistance;response;RNA Interference;Role;Signal Transduction;src-Family Kinases;Staphylococcus aureus;Staphylococcus aureus infection;Stress;System;Testing;Toxin;ubiquitin ligase;United States National Institutes of Health;VDAC1 gene;Vesicle

PROJECT_TITLE: LITAF regulation of membrane repair and inflammation

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

PHR: PROJECT NARRATIVE While the maintenance of cartilage health is critical for functional mobility, cartilage degradation, or osteoarthritis, is a common disease in older individuals. In this project, we will mechanistically interrogate the direct role of soluble and physical microenvironmental factors on the loss of cartilage integrity with aging and according to sex. We anticipate that the innovative research studies proposed will aid in the development of effective interventions that consider sex- and gender-specific variables for the treatment of osteoarthritis.

PI_NAMEs: AMBROSIO, FABRISIA  (contact);IIJIMA, HIROTAKA

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: 3-Dimensional;4-vinylcyclohexene diepoxide;Address;Age;age related;aged;Aging;aging population;Anatomy;Animals;Automobile Driving;Biological Models;Biomedical Engineering;biophysical properties;Blood;burden of illness;Cartilage;cartilage degradation;Cell Density;cell type;Cells;Chemicals;Chondrocytes;Clinical Data;Clinical Research;Collagen;Degenerative polyarthritis;Development;Dimensions;Disease;Disease Progression;effective intervention;Environmental Risk Factor;Estrogens;experience;Extracellular Matrix;Female;Fibrosis;Functional disorder;Gender;gender affirming hormone therapy;Genetic;Goals;Gonadal Steroid Hormones;Health;Hormonal;Hormones;Human;In Vitro;in vitro Model;in vivo;Incidence;Individual;innovation;insight;intercellular communication;Investigation;Joints;Knee Osteoarthritis;Learning;life span;machine learning algorithm;Maintenance;male;Mass Spectrum Analysis;Measures;Medicine;men;Menopause;middle age;Midlife women;Modeling;Morbidity - disease rate;Mus;Musculoskeletal;Nature;novel therapeutics;old mice;Older Population;Outcome;Pathogenesis;Pathogenicity;Pathology;Phenotype;Physiological;Physiology;Plasma;Postmenopause;prevent;Printing;Progesterone;Proteome;Proteomics;research study;response;Rodent;Role;Serum;sex;Sex Chromosomes;sexual dimorphism;Signal Transduction;stem cells;success;Supplementation;Synovial Fluid;System;systematic review;Testing;Time;Tissues;tool;transcriptomics;Transfusion;translational study;two-dimensional;Ultrafiltration;Woman;Work

PROJECT_TITLE: Gender and sex dimorphism in age-related knee osteoarthritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-F (50)]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Immunosuppressive mechanisms prevent immune cells and tissues from eliminating cancer cells. This proposal will examine how the A20 protein mediates these mechanisms, and how abrogating A20 functions can dramatically enhance antitumor immunity.

PI_NAMEs: MA, AVERIL I (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: A20 protein;Acute;Adoptive Transfer;Amino Acid Motifs;ATAC-seq;Binding;Biochemical;Biological Response Modifiers;cancer cell;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death Signaling Process;Cell Physiology;cell type;Cells;chimeric antigen receptor T cells;Clinic;combinatorial;CT26;cytokine;Cytometry;Data;Dissection;exhaust;exhaustion;Exhibits;Flow Cytometry;Genetic Epistasis;high dimensionality;Homeostasis;Human;Immune;Immune response;In Vitro;in vivo;Inflammatory;Knock-in Mouse;Ligase;Malignant Neoplasms;MC38;Mediating;Memory;Modeling;Molecular;mRNA Expression;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Myelogenous;novel;Pathway interactions;Phosphorylation;Polyubiquitin;Post-Translational Protein Processing;prevent;protein complex;Regulation;response;restraint;Role;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Solid Neoplasm;success;synergism;T cell differentiation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Tissues;tumor;Tumor Immunity;tumor microenvironment;Work

PROJECT_TITLE: A20 and Tumor Immune Responses


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autoimmune Disease;Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: SINAI HEALTH SYSTEM

ORG_STATE: ON

ORG_ZIPCODE: M5G 1X5

PHR: R21 Project Narrative Alzheimer Disease (AD) is a serious neurodegenerative disorder for which there are no known current therapies. In order to make strides in diagnosis and therapy of AD we need to identify biomarkers that discriminate between AD and other neurodegenerative disorders, assess the progression of the disease and design clinical trials for early prevention or therapy. Our project aims to identify biomarkers for differential diagnosis, assessment of progression and severity of AD.

PI_NAMEs: DIAMANDIS, ELEFTHERIOS P (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: accurate diagnosis;Affect;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapy;Alzheimer’s disease biomarker;Amyloid;Antibodies;Antigen-Antibody Complex;Antigens;Applications Grants;assay development;Autoantibodies;Autoantigens;Autoimmune;Autoimmune biomarker;Autoimmunity;biobank;Biological;Biological Assay;Biological Markers;biomarker identification;biomarker validation;Biostatistical Methods;Brain;candidate identification;Central Nervous System;Cerebrospinal Fluid;Clinical;Clinical Trials;Clinical Trials Design;Cognitive;Collaborations;Complex;COVID-19 assay;Dementia;design;Diagnosis;Diagnostic;diagnostic biomarker;diagnostic value;Differential Diagnosis;Disease;Disease Management;Disease Progression;early phase clinical trial;effective therapy;Enzyme-Linked Immunosorbent Assay;experimental study;falls;Future;G-substrate;Genetic;Goals;Hybrids;IgG autoantibodies;Immune;Individual;Industrialization;Inflammation;Investments;Liquid substance;magnetic beads;Mass Spectrum Analysis;Measurement;Methodology;Methods;mild cognitive impairment;Monitor;Neurodegenerative Disorders;neuroinflammation;neuron loss;neuropathology;New Agents;novel;novel therapeutics;Parkinson Disease;Pathogenesis;patient response;Patients;Persons;Phase;Prevention;Process;Prognostic Marker;prognostic value;Proteins;Proteome;Proteomics;Reaction;Recombinant Proteins;Role;Sampling;Serology test;Serum;Severities;Shotguns;Spain;Symptoms;Synapses;Technology;Testing;Therapeutic Agents;Time;vaccine trial;Validation;Variant

PROJECT_TITLE: Discovery and validation of biomarkers of autoimmunity in Alzheimer's Disease.


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Digestive Diseases;Mental Health;Microbiome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: WORCESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: NARRATIVE Alzheimer’s disease (AD) is a progressive neurodegenerative disease currently affecting 5.8 million Americans 65 or older and is associated with cognitive decline, neuroinflammation, and changes in the gut microbiome. To address the present limitations in our understanding of the factors contributing to AD, we aim to characterize the role of the commensal gut microbiome in both protecting individuals from AD and increasing disease risk by shaping the adaptive immune system. Our goal is that this work will both help to provide greater mechanistic understanding for the causes of AD and to identify key bacterial species which prevent the pathogenesis of AD to provide key targets for intervention and prevent or slow AD progression.

PI_NAMEs: LOEW, ETHAN BAILEY (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Address;Affect;Age;Alternative Therapies;Alzheimer's Disease;American;Anti-Inflammatory Agents;Antibiotics;Antigens;B-Lymphocytes;Bacteria;Behavioral;Biological Assay;Biological Response Modifiers;Blood;Blood - brain barrier anatomy;Blood specimen;Brain;C57BL/6 Mouse;Cell Line;Cells;Central Nervous System;Chemicals;Citrulline;Clinical;Coculture Techniques;cognitive testing;cohort;Colon;commensal bacteria;cytokine;Data;Deterioration;Development;Dextrans;Disease Progression;disorder risk;Elderly;Electrical Resistance;Engraftment;Epithelial Cells;Epithelium;equol;Extravasation;Feces;Functional disorder;gastrointestinal epithelium;genome sequencing;Germ-Free;Goals;gut bacteria;gut inflammation;gut microbiome;gut microbiota;Human;human old age (65+);Immune;Immune system;Immune Tolerance;Immunoglobulin Class Switching;Immunohistochemistry;immunosenescence;Impaired cognition;Individual;Infection;Inflammaging;Inflammation;Inflammation Mediators;Inflammatory;Intervention;intestinal barrier;intestinal epithelium;Intestinal permeability;Intestines;Investigation;Knowledge;Lamina Propria;Leukocyte L1 Antigen Complex;Link;lipopolysaccharide-binding protein;Lipopolysaccharides;Lymphatic;Maintenance;Measures;Mediator;Metabolic;microbial;microbial community;microbiome;microbiome analysis;microbiome composition;microbiota;microbiota-gut-brain axis;Modeling;Morphology;mouse model;Mucous Membrane;Mus;myelination;Nerve Degeneration;Neurocognitive Deficit;Neurodegenerative Disorders;Neurofibrillary Tangles;neurogenesis;neuroinflammation;novel;Outcome;Pathogenesis;Peripheral;peripheral blood;Peripheral Blood Lymphocyte;Permeability;Phytoestrogens;Plasma;Play;Population;prevent;Process;Property;Proteins;Publishing;random forest;Regulation;Research;Rest;Role;Sampling;Senile Plaques;Serum;Shapes;stool sample;System;systemic inflammatory response;Testing;theories;Time;Transgenes;whole genome;Work;zonulin

PROJECT_TITLE: Understanding the regulation of the intestinal epithelium in Alzheimer’s disease by commensal bacteria and the role it plays in preventing neurocognitive decline


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: ALBUQUERQUE

ORG_NAME: AMERICANS FOR INDIAN OPPORTUNITY

ORG_STATE: NM

PHR: Project Narrative Three sentences   With a collaborative approach grounded in Indigenous core cultural values, the Indigenous Innovators Collaborative (IIC) team will engage in community-based participatory research study to address the FDA priorities as outlined in FDA OMHHE Health Equity Innovation Award: Racial and Ethnic Minority Acceleration Consortium for Health Equity (REACH) funding opportunity. The IIC seeks to engage American Indian and Alaska Native (AIAN) communities, stakeholders, researchers in an exploration of clinical trials and promote cultural knowledge in understanding clinical trials in Indian Country. One of the fundamental goals of this study is to aid in identifying perceptions of clinical trials and gene therapy within the Native American population.

PI_NAMEs: KIPP, BILLIE ;PARKER, MYRA ELIZABETH;POSTON, STEPHINE  (contact)

PROGRAM_OFFICER_NAME: LEE, CHRISTINE

PROJECT_TITLE: Racial & Ethnic minority Acceleration Consortium for Health Equity (REACH) Response from Indigenous Innovators Collaborative


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Congenital Structural Anomalies;Genetics;Human Genome;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE The cerebellum is a critical structure for appropriate voluntary movements and is increasingly associated with element of higher cognitive function through connections with the frontal cortex. The proposed research will provide insight into the molecular regulation by which cerebellar granule cells—the most numerous neuron type in the brain—are generated. Elucidating the basic mechanisms that regulate the genesis of granule cells will provide critical insights into both developmental brain disorders and cancers arising from this lineage.

PI_NAMEs: BREUNIG, JOSHUA JOHN (contact);KAYE, JONATHAN G

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Ablation;ACTL6B gene;Acute;Anatomy;ATAC-seq;Ataxia;Attention deficit hyperactivity disorder;autism spectrum disorder;Biological Models;Brain;Brain Diseases;Brain region;Calcium Signaling;CD8-Positive T-Lymphocytes;Cell Fate Control;cell type;Cells;Cerebellar Ataxia;Cerebellar Diseases;Cerebellum;Childhood;chromatin remodeling;Chromium;chronic infection;Cleavage Under Targets and Release Using Nuclease;Cognition;Cognitive;cognitive function;comparison control;Complement;conditional knockout;Congenital cerebellar hypoplasia;Coupled;Data;Development;developmental disease;Disease;DNA Binding Domain;dopaminergic neuron;Dyslexia;Electroporation;Elements;Embryo;Emotions;Epigenetic Process;epigenetic regulation;Equilibrium;exhaustion;Family;Fourth ventricle structure;Fractionation;frontal lobe;Functional disorder;Gene Expression;gene network;Generations;Genes;Genetic;genome wide association study;Goals;granule cell;histogenesis;Histones;Human;human disease;Image;Immune system;In Vitro;in vivo;insight;Investigation;Knock-out;Knockout Mice;Label;Language;Light;Lip structure;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Mediating;member;Methods;Molecular;Motor;motor control;mouse model;Movement;multimodality;multiple omics;Mus;Mutagenesis;mutant;nerve stem cell;Nervous System;nestin protein;neural;Neuroanatomy;Neurons;notch protein;novel;Parkinson Disease;pars compacta;Pathologic;Pathology;Pattern;Phenotype;Population;precursor cell;Predisposition;Pregnancy;Primordium;Process;Prosencephalon;Protein Family;Proteins;Regulation;Repression;Research;Restless Legs Syndrome;Role;Satiation;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Site;spatial memory;spatiotemporal;Specific qualifier value;Structure;Substantia nigra structure;T-Lymphocyte;Tamoxifen;Time;Tissues;Titrations;transcription factor;transcriptomics;Ventricular;virtual;Work

PROJECT_TITLE: Defining the role of Tox3 in congenital cerebellar hypoplasia and ataxia

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: GABORONE

ORG_COUNTRY: BOTSWANA

ORG_FIPS: BC

ORG_NAME: BOTSWANA-HARVARD AIDS INSTITUTE

PHR: Pregnancy poses unique barriers to PrEP use, yet PrEP research among pregnant and postpartum women lags behind other populations. There is an urgent need for strategies with dual benefits for HIV and sexually transmitted infections (STIs) that enhance PrEP use in pregnancy and postpartum while scaling novel PrEP options. Our proposal is designed to fill knowledge gaps regarding co-delivery of STI testing and expanded PrEP options in antenatal care with the overall goal to improve PrEP use among pregnant and postpartum women in HIV priority settings.

PI_NAMEs: MORRONI, CHELSEA  (contact);PINTYE, JILLIAN

PROGRAM_OFFICER_NAME: LEE, SONIA S

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;African;antenatal;antenatal care;Antimicrobial Resistance;arm;Birth;Botswana;Breast Feeding;Caring;Client;Client satisfaction;Clinic;cofactor;Collaborations;Dapivirine;Data;design;Diagnostic tests;Enrollment;Epidemic;Evaluation;Goals;Hair;Health;Health Personnel;Health Priorities;HIV;HIV Infections;HIV risk;Human immunodeficiency virus test;implementation evaluation;implementation outcomes;improved;Incidence;Individual;Inequity;Infant;infection management;infection rate;Injectable;Intervention Studies;Interview;Knowledge;Lactation;Low Birth Weight Infant;Methods;Modeling;Mothers;Nausea;novel;Nurses;Oral;Outcome;perinatal outcomes;Persons;Pharmaceutical Preparations;Physicians;pill;Policies;Population;Positioning Attribute;Postpartum Period;Postpartum Women;pre-exposure prophylaxis;Pregnancy;Pregnancy loss;pregnant;Pregnant Women;Premature Birth;Prevalence;primary outcome;Proctor framework;programs;prospective;Provider;Qualitative Evaluations;Quality of Care;Randomized;randomized trial;Recommendation;Research;Research Infrastructure;Risk;risk perception;Safety;safety assessment;safety outcomes;Sampling;scale up;secondary outcome;Sexually Transmitted Diseases;side effect;Small for Gestational Age Infant;Southern Africa;standard of care;stillbirth;Symptoms;Testing;tool;Translations;trial comparing;uptake;Vaginal Ring;Woman;Women's trial;young woman

PROJECT_TITLE: Improving PrEP outcomes among pregnant women in Botswana with an integrated STI testing and PrEP delivery model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-H (50)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE The second messenger cyclic-di-AMP is essential for viability or virulence in most Gram-positive bacteria, including Staphylococcus aureus, Listeria monocytogenes, Mycobacterium tuberculosis, and Bacillus anthracis. This grant aims to elucidate the mechanisms by which bacteria sense external stimuli and modulate the pools of this cyclic nucleotide in response. My findings have the potential to inform the development of drugs that could alter cyclic-di-AMP levels and re-sensitize drug-resistant bacteria to frontline antibiotics.

PI_NAMEs: BROGAN, ANNA P (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Bacillus;Bacillus anthracis;Bacillus subtilis;Bacteria;bacterial resistance;beta-Lactams;Biogenesis;cell envelope;Cell Wall;Cells;clinically relevant;Clostridium difficile;Complex;Cyclic Nucleotides;Cyclization;Cytolysis;Cytoplasm;Cytoplasmic Tail;Defect;Dinucleoside Phosphates;Disease;drug development;Drug Sensitization;Drug Targeting;Enterococcus;Enterococcus faecalis;Enzymes;Esthesia;experience;extracellular;Genes;Gram-Positive Bacteria;Grant;Growth;Homeostasis;Impairment;Knowledge;Listeria monocytogenes;Membrane;Methicillin;methicillin resistant Staphylococcus aureus;Modeling;Molecular;Monitor;mutant;Mutation;Mycobacterium tuberculosis;Nucleotides;Organism;pathogen;Pathogenesis;Pathway interactions;Peptidoglycan;Periodicity;phosphoric diester hydrolase;Play;Potassium;Predisposition;pressure;Proteins;Publishing;Regulation;repaired;Research;Research Personnel;Resistance;response;Role;screening;Second Messenger Systems;sensor;Signal Transduction;skills;solute;Staphylococcus aureus;Stimulus;Testing;Therapeutic;Training;transposon sequencing;uptake;Vaccine Therapy;Virulence;Work

PROJECT_TITLE: Molecular basis of cyclic-di-AMP regulation in Gram-positive bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Immunotherapy;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Debilitating conditions such as Lewy body dementias (LBDs) belong to a spectrum of disorders that currently have no available disease modifying therapies. Recent studies point to the role of dysregulated lipid metabolism in LBDs, and developments in imaging mass methods enable the in situ analyses of lipid species in mouse brain tissue samples. The present study uses matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS), for direct anatomical analysis of lipid alterations as a function of time in brain sections from preclinical models of LBD, to determine lipid profiles from disease, non-disease controls, and animals treated with immunotherapy, which restores lipid homeostasis, to draw robust conclusions about lipid alterations in the course of LBD and after application of therapeutic intervention.

PI_NAMEs: PRENTICE, BOONE M.;VEDAM-MAI, VINATA  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Ablation;Affect;Aging;alpha synuclein;Anatomy;Animals;Architecture;Atlases;Attenuated;Automobile Driving;Basal Ganglia;Behavior;Behavior assessment;Behavioral;Biological Markers;Brain;Brain Diseases;Brain Mapping;Brain Stem;brain tissue;Breeding;cell type;Cellular immunotherapy;cofactor;Cognition;cognitive function;Data;Dementia with Lewy Bodies;design;Development;Diglycerides;discrete time;Disease;Disease Marker;Disease Progression;dopaminergic neuron;Environment;Enzymes;frontal lobe;Functional disorder;Future;Genes;Glycerolipid Metabolism Pathway;Goals;Hippocampus;Homeostasis;Image;immunoregulation;Immunotherapy;improved;In Situ;in vivo;Injections;Intramuscular;Knowledge;Label;Lewy Bodies;Lewy Body Dementia;Link;Lipid Binding;lipid metabolism;lipidome;lipidomics;Lipids;Literature;Lysophosphatidylcholines;Maps;mass spectrometric imaging;Measures;Messenger RNA;Metabolic;metabolic imaging;metabolome;Methods;Modeling;Monitor;Motor;mouse model;Mus;Mutate;NADP;Nerve Degeneration;Neuroglia;neuropathology;new technology;Nonesterified Fatty Acids;novel;novel therapeutic intervention;novel therapeutics;overexpression;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;Phosphatidic Acid;Play;Pre-Clinical Model;pre-formed fibril;Reporting;Resolution;restoration;Role;sex;Signal Pathway;small molecule;Spatial Distribution;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Systems Biology;T cell therapy;T-Lymphocyte;Technology;Testing;Thalamencephalon;Therapeutic Intervention;Time;Tissue Sample;Tissues;transcriptome sequencing;Triglycerides;uptake;Visualization;Work

PROJECT_TITLE: Mapping Brain Lipid Architecture in Aging, LBD and T Cell Therapy using novel Imaging Mass Spectrometry

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: PROJECT NARRATIVE In the cell, many different cargos must be transported with spatial and temporal precision, and defects in intracellular transport are prevalent in many neurological disorders. There is an incredible diversity of cellular transport behavior and modalities in nature—how do different cells transport cargo, and how do they adapt the transport machinery for their specific needs? This proposal will investigate the evolution of different modes of cargo transport.

PI_NAMEs: CHRISTENSEN, JENNA  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TITLE: Evolution of Cargo Transport

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dietary Supplements;Genetics;Human Genome;Microbiome;Nutrition

PI_NAMEs: TURNBAUGH, PETER JAMES (contact)

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: Antineoplastic Agents;Area;Bacterial Genes;bacterial metabolism;Biochemical;Cancerous;Cells;Chemotherapy-Oncologic Procedure;circadian;Circadian Rhythms;cohort;Compensation;Country;data integration;design;Diet;dietary;Dihydropyrimidine Dehydrogenase;Disease;Dissection;Dose;drug efficacy;drug metabolism;Drug toxicity;Drug usage;Enzymes;Escherichia coli;Fasting;feeding;fluoropyrimidine;Fluorouracil;Folic Acid;Food;Fortification;Gene Expression;Genes;Genetic Polymorphism;Gnotobiotic;Growth;gut bacteria;gut microbiome;gut microbiota;Hepatic;Human;Human Genome;Impairment;Intake;inter-individual variation;intervention effect;Intestines;Malignant Neoplasms;Metabolic Pathway;Metabolism;microbiome;Micronutrients;mouse model;Mus;Mutagenesis;Operon;Oral;parent project;Pathway interactions;Patients;Periodicity;Pharmaceutical Preparations;Physiological;Prevalence;pyrimidine metabolism;Research;response;Role;Shapes;side effect;Source;Testing;Therapeutic;Tissues;Toxic effect;treatment optimization;tumor metabolism;Xenograft Model

PROJECT_TITLE: Metabolism of cancer chemotherapeutics by the human gut microbiome

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Prevention

PHR: PROJECT NARRATIVE Mapping the structure and function of neural circuits is an important prerequisite to understand how groups of interconnected neurons produce perceptions and drive behavior. Here, we will use molecular design and in vivo work in Drosophila to develop and test a new method to re-engineer the connectivity of brain circuits, by preventing the formation of specific synapses between neurons. Our strategies are in principle applicable to any genetic system and will enable scientists to design new experiments and interventions not possible with existing techniques.

PI_NAMEs: GALLIO, MARCO  (contact);OZKAN, ENGIN

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Adoption;Adult;Animals;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Binding;Biochemistry;Biological;Biological Assay;Biological Models;Brain;Cell Aggregation;Cell Culture Techniques;Cell Surface Receptors;Communities;Complex;Cultured Cells;design;Development;Drosophila genus;Electrophysiology (science);Engineering;Epilepsy;expectation;experimental study;Feeling;flexibility;fly;Functional disorder;Future;Genetic;Genetic Complementation Test;Genetic Engineering;Genetic Models;Genetic study;Goals;Human;human disease;Human Genetics;In Vitro;in vitro Assay;in vivo;in vivo evaluation;Individual;insight;Intervention;Knowledge;Label;Lead;Ligands;Maps;Membrane;Methods;Microscopy;Modeling;Molecular;molecular modeling;Monitor;Mus;Mutation;neural;neural circuit;Neurobiology;Neurologic;Neurons;Neurophysiology - biologic function;novel;overexpression;patch clamp;Pathway interactions;Perception;postsynaptic;presynaptic;prevent;Prevention;Process;progenitor;Protein Engineering;Reagent;real world application;receptor;Receptor Gene;Residual state;Scientist;screening;Structure;Synapses;Synaptic Transmission;synaptogenesis;System;Techniques;Technology;Testing;Time;Transgenic Organisms;Translations;Variant;Viral;Work

PROJECT_TITLE: Molecular design for circuit engineering in the Drosophila brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (08)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Telehealth;Women's Health Research

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative As PrEP delivery methods change, decision making about how best to use PrEP and the pros and cons to each is important, especially for young trans women ages 15-24 who are less likely to use PrEP and have significant barriers to advocating for their wishes in a healthcare setting. Decision support tools designed to consider and address specific concerns and information gaps young trans women have related to PrEP and its delivery methods could support better informed decisions and empower them to try PrEP. We will develop and pilot test the web-based QUEEN-P decision support tool in young trans women to assess acceptability, feasibility and promise of efficacy in supporting informed decisions around PrEP and clarifying values in method delivery.

PI_NAMEs: BASS, SARAH B (contact);CASTILLO, MARNE

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: 3-Dimensional;acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adherence;Advocate;Age;age related;AIDS prevention;arm;Attitude;Awareness;Bass;Caring;Clinical;Communication;Communities;community partners;Conflict (Psychology);Counseling;cultural competence;cultural values;Data;Decision Making;design;Devices;Dimensions;Discrimination;eHealth;Electronics;empowerment;Event;experience;Family;Feedback;follow-up;Funding;Gender;Goals;Health;Health behavior change;health care settings;Health Personnel;Health Promotion;high risk;HIV;HIV disparities;HIV Infections;HIV risk;hormone therapy;improved;Individual;Injectable;innovation;insight;interest;Intervention;Interview;Knowledge;Location;Maps;Marketing;Medical;Mental Health;Methods;Modality;Modeling;National Institute of Mental Health;novel;Online Systems;Oral;outreach;Patient Self-Report;Perception;Persons;Philadelphia;pill;Pilot Projects;pilot test;Population;pre-exposure prophylaxis;preference;Preparation;primary outcome;prototype;Provider;Public Health;Randomized;Readiness;Research;Resources;secondary outcome;social;Social Network;social stigma;support tools;Surveys;Tablets;Techniques;Technology;Testing;theories;transgender women;Trust;United States;uptake;usability;vector;Voice;Work

PROJECT_TITLE: Developing and pilot testing an eHealth decision support tool for young trans women to improve informed decision 	making about PrEP


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Immunotherapy;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE The purpose of this proposal is to develop gene-edited (CD52-knockout) virus-specific T cells, and to determine the impact of gene editing on antiviral activity as well as off-target effects of CRISPR editing. Using a mouse model, we will test the efficacy and safety of CD52-KO virus-specific T cells. Completion of this study will develop a novel cellular therapy product that can be used in the presence of alemtuzumab, and additionally produce a pipeline for development of next-generation, gene-modified virus-specific T cells to more effectively treat immunocompromised patients who are at risk of severe viral infections.

PI_NAMEs: KELLER, MICHAEL DANIEL (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Adenoviruses;Adhesions;Adoptive Immunotherapy;Adult;Adverse event;alemtuzumab;Anti-viral Therapy;Antigens;B-Cell Leukemia;Biological;Biological Assay;Biological Products;CDW52 gene;Cell model;Cell Physiology;Cell Therapy;Cells;Childhood;chimeric antigen receptor T cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Color;CRISPR/Cas technology;cytokine;Cytomegalovirus;cytotoxicity;cytotoxicity test;Data;Development;efficacy testing;Evaluation;Flow Cytometry;Gene Expression Profile;Gene Modified;Generations;Genes;Genome-wide Unbiased Identification of DSBs Enabled by sequencing;Goals;graft vs host disease;Guide RNA;Hematopoietic Stem Cell Transplantation;high risk;Human;Human Herpesvirus 4;Immune;Immunity;Immunocompromised Host;Immunophenotyping;improved outcome;in silico;in vivo;Infusion procedures;Interferons;Knock-out;Lead;Leukocytes;Maintenance;Malignant - descriptor;Methods;Morbidity - disease rate;mortality;mouse model;Mus;next generation;Non-Malignant;novel;Oncology;Organ Transplantation;Patients;Peptides;Peripheral Blood Mononuclear Cell;Phase;Phenotype;Physiologic pulse;Plasma;Population;Prevention;Production;Proliferating;prophylactic;reconstitution;Refractory;Resolution;Risk;Safety;single-cell RNA sequencing;Solid;Sorting;Specificity;Spottings;Surface;System;T cell receptor repertoire sequencing;T cell therapy;T-Cell Depletion;T-Lymphocyte;Testing;Therapeutic immunosuppression;Toxic effect;transforming virus;Transplantation;Treatment Failure;tumor;Viral;Viral Antigens;Viral Physiology;Virus;Virus Diseases

PROJECT_TITLE: Enhancing efficacy of virus-specific T cell therapy following hematopoietic stem cell transplantation by CD52 knockout

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (M1)]


ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Tumor-Associated Macrophages (TAMs) constitute a metabolically and functionally heterogeneous cell population of the tumor microenvironment (TME) that play critical roles in tumor growth as well as in anti-tumor immune responses. Nearly 40 years ago, it was demonstrated that inhibition of the mitochondrial electron transport chain (ETC) is critical for the anti-tumor activity of macrophages; however, the mechanisms by which the activity of the ETC is controlled in TAMs and how this process determines the functions of these innate immune cells within the TME is largely unknown. Therefore, the overarching goal of this proposal is to mechanistically uncover how a small peptide and a microRNA encoded by a single transcript act as an evolutionarily conserved immune checkpoint that determines the functional differentiation of TAMs in response to specific signals within the TME through the regulation of Complex IV of the ETC.

PI_NAMEs: HENAO-MEJIA, JORGE  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Address;anti-tumor immune response;cancer clinical trial;cancer immunotherapy;CD8-Positive T-Lymphocytes;cell killing;Cells;Cellular Metabolic Process;chimeric antigen receptor;Complement;Complex;complex IV;conditional knockout;Consumption;Core Protein;cytochrome c;cytochrome c oxidase;Data;Development;Electron Transport;Engineering;Enzymes;exhaustion;Gene Expression;Genes;Genetic;genetic signature;Goals;Human;humanized mouse;Immune;immune checkpoint;immune checkpoint blockade;immune function;Immune response;Infiltration;Inflammatory;inhibitor;innate immune function;Interferon Type I;Interferon Type II;Interferons;Knockout Mice;Knowledge;loss of function mutation;Macrophage;Measures;Mediating;Melanoma Tumor;Metabolic;Metabolism;metabolomics;MicroRNAs;Mitochondria;molecular modeling;mouse model;Mouse Strains;Multiprotein Complexes;Mus;Myeloid Cells;Natural Killer Cells;Neoplasms;neoplastic cell;new technology;novel;novel therapeutic intervention;Oxygen;Patients;Peptides;Phenotype;Play;Population;Population Heterogeneity;Process;Prognostic Factor;programs;Protein Isoforms;Protein Subunits;Reactive Oxygen Species;Regulation;Reporter;Reporting;Resolution;response;Role;Signal Transduction;Testing;Time;Tissues;Transcript;transcriptomics;Transforming Growth Factors;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;Untranslated RNA;Up-Regulation;Work

PROJECT_TITLE: Non-coding RNA regulation of Myeloid Cells


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STRUCTURAL BIOLOGY CENTER

PHR: Project Narrative CryoET has unique capabilities for directly visualizing macromolecular associations and organization in native cells. NCITU will provide nationwide access to state-of-the-art equipment, technical support, cross-training, and methods development towards disseminating new services to enable and streamline specimen preparation for cryoET.

PI_NAMEs: DE MARCO, ALEX ;KIEFT, JEFFREY S (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Area;base;Biological;career;Cell Culture Techniques;Cells;Computers and Advanced Instrumentation;Cryoelectron Microscopy;Cryoultramicrotomy;Data Collection;Dedications;design;Development;Electron Microscopy;Ensure;Environment;Equipment;expectation;experience;Freezing;Goals;improved;In Situ;innovation;instrumentation;Intention;Ions;Laboratory Research;Lifting;light microscopy;method development;Methods;new technology;New York;novel;novel strategies;operation;Outcome;Preparation;pressure;Procedures;Protocols documentation;Qualifying;Research Personnel;Research Project Grants;Resolution;Running;Sampling;Science;screening;Services;skills;Specimen;structural biology;Supervision;Techniques;Technology;technology development;technology validation;Time;Tissues;tomography;Training;Training Programs;Visualization;Work

PROJECT_TITLE: The National Center for In-situ Tomographic Ultramicroscopy (NCITU)


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Narrative:  High-end electron microscopy and cryo-electron tomography are highly specialized and expensive technologies. To pool expertise and high-end equipment, the creation of hub-like service centers, open to the scientific community, has been propagated since several years. Here we propose to form a service unit that is integrated in a wider network, acting together for the benefit of the EM community in a similar fashion as synchrotrons are for X-ray protein crystallography projects.

PI_NAMEs: HOENGER, ANDREAS  (contact);LUGER, KAROLIN ;STOWELL, MICHAEL H. B.

PROJECT_TITLE: CU Boulder Center for Cryo-ET (CCET)


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Modified Public Health Relevance Section We propose to establish the Midwest Center for Cryo-Electron Tomography (MCCET) at the University of Wisconsin, Madison, a National Service Network Hub for Cryo-Electron Tomography. The MCCET will provide national and international access to state-of-the-art equipment and well-trained technical staff to support the growing need for cryo-ET of biomedically-relevant specimens from isolated macromolecules to tissue from organisms. The MCCET will enable researchers, inside and outside of the national network of service centers, to prepare specimens suitable for on-site cryo-ET data acquisition and data processing, and to train and cross-train in a broad-range of cryo-ET workflows.

PI_NAMEs: WRIGHT, ELIZABETH R (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Administrator;Biochemistry;Biological Sciences;Carbon;Cell Culture Techniques;Complex;computer scientist;computerized data processing;Computers;Cryo-electron tomography;Cryoelectron Microscopy;cryogenics;data acquisition;Data Collection;Database Management Systems;Development;Devices;Discipline;Electron Microscope;Electron Microscopy;Ensure;Equipment;evaporation;experience;Fluorescence;Grant;Human Resources;Image;Image Analysis;image processing;improved;Individual;innovation;Institution;instrumentation;International;Ions;Laboratory culture;Light Microscope;macromolecule;materials science;member;Methods;Midwestern United States;Molecular Biology;operation;Organelles;Organism;Pattern;Postdoctoral Fellow;Preparation;preservation;pressure;public health relevance;Recording of previous events;recruit;Research;Research Personnel;Resources;Robot;Role;Sampling;Scanning;Services;Site;skills;small molecule;Specimen;Standardization;System;Teacher Professional Development;Technology;technology development;Tissues;Training;Training Activity;United States National Institutes of Health;Universities;Validation;virtual;Wisconsin

PROJECT_TITLE: The Midwest Center for Cryo-Electron Tomography


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative Statement We propose to establish the Stanford-SLAC CryoET Specimen Preparation Service Center (SCSC) to meet the emerging national need for cryoET as a structural biology tool. The Center facility will enable external users to streamline the preparation of samples through providing access to, and support for, advanced cryo-specimen preparation techniques (cryoFLM, cryoFIB, and cryoEM/ET) for a wide range of samples with biomedical applications. The Center will offer a comprehensive program to train and cross-train scientists, regardless of their institutional affiliations, to become independent cryoET investigators.

PI_NAMEs: CHIU, WAH  (contact)

PROJECT_TERMS: Academia;Adopted;Advisory Committees;Area;Award;Biocompatible Materials;Biological;Biomedical Research;Cells;Cellular Structures;Collaborations;Communication;Communities;Complex;Cryo-electron tomography;Cryoelectron Microscopy;cryogenics;Data Collection;data management;Dedications;Educational Curriculum;Educational workshop;electron tomography;Equipment;Evaluation;experience;experimental study;Fluorescence Microscopy;Freezing;Funding;Goals;Grant;Hydration status;imaging modality;In Situ;Industry;Infrastructure;innovative technologies;Institution;instrument;instrumentation;interest;Investigation;Ions;Laboratories;Lifting;Macromolecular Complexes;member;Methods;Microscope;Molecular Structure;nanometer resolution;operation;Organelles;Preparation;Process;Productivity;Professional Organizations;programs;Protocols documentation;Recurrence;Request for Applications;Research;Research Personnel;Resource Allocation;Resources;response;Sampling;Scanning Electron Microscopy;Schedule;Scientist;Selection Criteria;Services;Specialized Center;Specimen;structural biology;Subcellular structure;symposium;Techniques;Technology;Tissue Sample;Tissues;Titan;tool;Training;Training Activity;United States National Institutes of Health;web portal;Work


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Pain Research;Prevention;Rare Diseases;Sickle Cell Disease;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  This study will elucidate sex- and gender-related mechanisms of the disparity in vaso-occlusive pain between females and males with sickle cell disease and test the clinical and biomarker effects of menstrual cycle suppression with depot medroxyprogesterone acetate, a hormonal contraceptive. Because sickle cell disease affects millions of people worldwide, and vaso-occlusive episodes present a public health burden in the United States and abroad, new strategies for pain prevention that emerge from this research will have a significant impact on patient morbidity and health care costs. We seek to fulfill NHLBI and NIH Women’s Health Research objectives to identify sex and gender influences in disease outcomes in order to better target interventions and ultimately close this important clinical gap in sickle cell disease.

PI_NAMEs: ROE, ANDREA  (contact)

PROJECT_TERMS: Acute;Affect;Biochemical;Biological;Biological Assay;Biological Markers;black women;Blood specimen;Blood Vessels;C-reactive protein;Cell Adhesion;Chronic;Chronic Disease;Clinical;clinical practice;cohort;Contraceptive Agents;Cross-Sectional Studies;Data;Death Rate;Depo Provera;Disease Outcome;Disparity;Endothelium;Enrollment;Exhibits;experience;Face;Female;female sex hormone;Feminine;Frequencies;Functional disorder;Gender;Gender Identity;General Population;Goals;Gonadal Steroid Hormones;Gonadotropins;Health;Health Care Costs;health disparity;Hemolysis;Hormonal;hormonal contraception;improved;Individual;Inflammation;Inflammatory;inflammatory marker;Intervention;Intervention Studies;Luteal Phase;male;Maternal Mortality;Measures;Mediating;Medroxyprogesterone;Medroxyprogesterone 17-Acetate;Menstrual cycle;Menstruation;Microfluidics;Morbidity - disease rate;National Heart, Lung, and Blood Institute;novel;Outcome;Pain;pain outcome;pain sensitivity;Pathway interactions;Patients;Pattern;Pennsylvania;perimenstrual;Periodicity;Persons;Phase;Physiology;Plasma;Play;post intervention;prevent;Prevention;Progestins;proliferative phase Menstrual cycle;prospective;Prospective Studies;Public Health;Race;recruit;Reporting;Research;Role;sample collection;Severities;sex;Sickle Cell Anemia;social culture;stem;Survival Rate;System;Testing;Therapeutic;therapeutic effectiveness;Thrombosis;Time;trend;United States;United States National Institutes of Health;Universities;vaso-occlusive pain;willingness;Women's Health;women's prevention

PROJECT_TITLE: Sex and gender influences on inflammation and pain in sickle cell disease


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Prevention

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

PHR: PROJECT NARRATIVE Genetic variation in the human population contributes to inflammatory bowel disease (IBD) risk, but the mechanisms that drive genetic risk are unknown. Here, we use cutting-edge high-throughput methods to pinpoint causal genetic variants associated with IBD and define the genes and pathways they impact. We will accomplish this in primary pathogenic Th17 cells, a key IBD-relevant cell type, to how risk variants affect their gene expression, migration, and function.

PI_NAMEs: HARRISON, OLIVER JAMES;RAY, JOHN PHILIP (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;Affect;Alleles;Autoimmune;Automobile Driving;B-Lymphocytes;Biological Assay;causal variant;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Line;cell motility;Cell Physiology;cell type;Cells;Chromatin;Collaborations;Colon;CRISPR interference;Diagnosis;Disease;disease model;Disease Pathway;disorder risk;East Asian;European;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Diseases;Genetic Predisposition to Disease;Genetic Risk;genetic variant;Genetic Variation;Genome;genome wide association study;Grant;Helicobacter hepaticus;Homeostasis;Human;Immune;In Vitro;in vivo;Individual;Inflammation;Inflammatory Bowel Diseases;insight;Knowledge;Lamina Propria;Link;Linkage Disequilibrium;Maps;Methods;migration;Monozygotic twins;mouse model;Nucleic Acid Regulatory Sequences;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Physiological;Population;Probability;Process;Regulatory Element;Reporter;Research;Risk;risk variant;screening;Susceptibility Gene;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Therapeutically Targetable;United States;Untranslated RNA;Variant;Work

PROJECT_TITLE: Genetic variants guiding pathogenicity of colitogenic T cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-C (M1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative  The study advances the priorities of the NIH-wide IMPROVE initiative, by building skills to address IPV as a preventable cause of maternal death and poor health before, during, and after delivery, and disparities therein (e.g. race/ethnicity, life course stages, and social standing). Results will accelerate the quality and impact of clinical and intervention-related IPV research for populations in greatest need, contributing to our national ability to ensure women’s health and safety and promote health equity.

PI_NAMEs: DECKER, MICHELE R. (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Applied Skills;Behavioral;career;career development;Cause of Death;Clinical;Clinical Research;Communities;Competence;Course Content;culturally appropriate intervention;Dedications;design;Development;Disparity;Educational Curriculum;Educational Status;effective intervention;Eligibility Determination;Ensure;Epidemiology;epidemiology study;Ethics;Ethnic Origin;Evaluation;evidence base;experience;Faculty;Female;Fostering;Goals;Hand;Health;health equity;health equity promotion;Home;Homicide;improved;Individual;innovation;Institution;Intervention;Intervention Studies;intimate partner violence;Knowledge;learning strategy;Life Cycle Stages;Maternal Health;maternal morbidity;Maternal Mortality;maternal safety;Measurement;Measures;Mental Health;Mentors;Modeling;Morbidity - disease rate;mortality;multidisciplinary;online course;Pathway interactions;perinatal period;Peripheral;policy recommendation;Population;Population Heterogeneity;post pregnancy;Pregnancy;Pregnancy Outcome;pregnancy related death;Prevalence;prevent;programs;Protocols documentation;Psychological Stress;Public Health;Race;Research;Research Personnel;Research Technics;Risk;Risk Factors;Safety;Scholarship;screening;Series;severe maternal morbidity;Severities;skills;Social status;Suicide;Training;training project;Translating;Translational Research;Trauma;United States National Institutes of Health;Universities;uptake;violence exposure;Woman;Women's Health

PROJECT_TITLE: Applied IPV Measurement (AIM) Shortcourse

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-H (53)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative There is high unmet need for PrEP among cis-gender women in the U.S. and, even where PrEP is available, it is often inaccessible to women because too few clinical settings provide it. We address this important adoption gap by integrating PrEP decision-making and delivery into contraceptive counseling in sexual and reproductive health clinic settings, which supports women’s choice. Guided by the Health Equity Implementation Framework and sustained input from a Community Advisory Board, we will randomize patients in these settings to receive an expanded PrEP decision aid vs. generic PrEP information, evaluating clinical and implementation outcomes important for understanding scalability and sustainability.

PI_NAMEs: MEYER, JAIMIE  (contact);SHETH, SANGINI S.

PROJECT_TERMS: Address;Adoption;Affect;AIDS prevention;American;Attitude;Awareness;Baltimore;black women;Caring;Centers for Disease Control and Prevention (U.S.);Cervical Cancer Screening;Characteristics;cis-female;Clinic;Clinical;clinical efficacy;clinical encounter;college;community advisory board;community setting;Connecticut;Contraceptive Agents;Contraceptive methods;cost;Counseling;Data;Decision Aid;Decision Making;Discipline of obstetrics;distrust;Domestic Violence;Educational Intervention;effectiveness/implementation study;Eligibility Determination;empowerment;Epidemiology;Equity;Ethnic Origin;experience;Family Planning;Federally Qualified Health Center;follow-up;Formulation;Future;Gender;Gynecology;health equity;Health Policy;HIV;Homelessness;Hybrids;implementation determinants;implementation framework;implementation outcomes;implementation science;Individual;infrastructure development;innovation;insight;interest;Intervention;Interview;Justice;Knowledge;Legal;Legal system;marginalization;Medical;Methods;Motivation;NIH Office of AIDS Research;patient engagement;patient oriented;patient population;Patients;Penetration;Persons;pilot trial;pre-exposure prophylaxis;pregnancy prevention;pregnant;prevent;Prevention;primary outcome;Provider;Public Health;Publishing;Race;racism;Randomized;Recommendation;reproductive;Reproductive Health Services;Research;Resources;Sales;scale up;Science;Service setting;Services;sexual and reproductive health;Sexually Transmitted Diseases;Side;Site;social stigma;socioeconomics;Structure;substance use;Substance Use Disorder;System;Technology;Testing;Training;Trauma;Trust;United States Preventative Services Task Force;Visit;Woman;Women's study;Work;World Health Organization

PROJECT_TITLE: Integrating PrEP Decision-Making into Contraceptive Counseling in Family Planning Clinics


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Because current care delivery strategies for HIV pre-exposure prophylaxis (PrEP) do not adequately address the unique needs and priorities of Black and Latinx sexual minority men (BLSMM), use remains low. In collaboration with a diverse group of stakeholders, we will use system dynamics group model building to identify and model strategies likely to address barriers to PrEP access and use, and then pilot test the most promising strategies. By enhancing PrEP uptake, this study has the potential to reduce HIV transmission and improve the health of BLSMM.

PI_NAMEs: LOUNSBURY, DAVID WILLIAM;ROSS, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Action Research;Address;Advisory Committees;Area;Automobile Driving;barrier to care;Black race;care delivery;Caring;Collaborations;Communities;community collaboration;community engaged approach;community engaged research;community organizations;Complex;Consensus;Consolidated Framework for Implementation Research;Creativeness;Data;Data Sources;design;Disadvantaged;disparity reduction;dynamic system;Effectiveness;Epidemic;experience;Face;Fright;Funding;Goals;Health;health care availability;health care delivery;health inequalities;Health Personnel;HIV;HIV diagnosis;HIV disparities;HIV Infections;HIV risk;HIV Seronegativity;Immigration;implementation framework;implementation outcomes;implementation science;implementation strategy;Improve Access;improved;Incidence;Intervention;Knowledge;Latinx;Lead;Maps;Measures;Medical;Medical center;men;model building;Modeling;Monitor;New York City;NIH Office of AIDS Research;novel;outcome disparities;Persons;Phase;pilot test;Population;Positioning Attribute;Poverty;pre-exposure prophylaxis;Process;Proctor framework;Research;Research Infrastructure;Research Methodology;Research Priority;response;Risk;sexual minority men;Sexually Transmitted Diseases;simulation;social stigma;Specific qualifier value;Structure;substance use;syndemic;System;Testing;theories;transmission process;Transportation;Trauma;United States Health Resources and Services Administration;uptake;Work

PROJECT_TITLE: Participatory System Dynamics to Enhance PrEP Access for Black and Latinx Sexual Minority Men in Bronx, NY

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (06)]