ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE This K01 proposal aims to design a new genetic engineering platform to program T cells to adopt and maintain desirable fates for tumor control via specific transcription factors. These enhanced T cells will not only infiltrate and kill cancer cells, but also retain the immunological memory leading to complete remission.

PI_NAMEs: CHUNG, HOKYUNG KAY (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Adopted;Adoptive Cell Transfers;Antigens;Antitumor Response;Atlases;Automobile Driving;Binding;Bioinformatics;cancer cell;cancer therapy;CD8-Positive T-Lymphocytes;Cell membrane;Cell Reprogramming;Cells;chimeric antigen receptor T cells;Clinical;clinically relevant;Code;combinatorial;Combinatorics;cytotoxic;design;Disease remission;Doctor of Philosophy;Effectiveness;effector T cell;engineered T cells;Engineering;Epigenetic Process;epigenomics;Eragrostis;Evaluation;exhaust;exhaustion;Fostering;Functional disorder;Genetic;Genetic Engineering;Genetic Transcription;genomic data;Goals;Human;immune checkpoint blockade;Immunity;Immunologic Memory;Immunology;Immunotherapy;improved;In Situ;in vivo;in vivo Model;Individual;Infiltration;innovation;Knowledge;Malignant Neoplasms;Memory;Methodology;Methods;Modification;next generation;novel;novel strategies;Pathway interactions;Pharmaceutical Preparations;prevent;Process;programmed cell death protein 1;programs;Proliferating;Protein Engineering;receptor;Receptor Signaling;Rejuvenation;Research;Resistance;Route;Signal Pathway;Signal Transduction;single cell sequencing;Site;small hairpin RNA;Soldier;Solid Neoplasm;Specificity;synthetic biology;T cell differentiation;T cell infiltration;T cell therapy;T memory cell;T-Cell Development;T-Cell Transformation;T-Lymphocyte;Testing;Therapeutic;tissue resident memory T cell;Tissues;trafficking;Training;transcription factor;Transcriptional Regulation;transcriptional reprogramming;translational applications;translational potential;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor-infiltrating immune cells

PROJECT_TITLE: Next-generation T cell therapy: SMARTER T cells for enhanced and durable anti-tumor immunity


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: NOTRE DAME

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative The metastasis of cancerous cells to distant and vital organs is responsible for approximately 90% of cancer mortalities, and it is clear that an important barrier to tumor progression and metastasis is the survival of cancer cells that are detached from the extracellular matrix (ECM). However, our understanding of the molecular mechanisms underlying the survival of ECM-detached cancer cells remains rudimentary. This proposal seeks to examine how a novel pathway involving RIPK1 and the degradation of mitochondria can restrict breast cancer progression.

PI_NAMEs: SCHAFER, ZACHARY T. (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: 3-Dimensional;Address;Anchorage-Independent Growth;Anoikis;Antioxidants;Applications Grants;Biological;Biological Assay;Breast Cancer Cell;Breast Cancer Patient;breast cancer progression;cancer cell;Cancer Patient;cancer survival;Cancerous;Caspase;Cell Culture Techniques;Cell Death;Cell Survival;Cells;Cessation of life;combat;Complex;Data;Death Rate;design;Development;Disease;Disseminated Malignant Neoplasm;Distant;Epithelial Cells;Exposure to;Extracellular Matrix;FDA approved;in vivo;insight;Integrins;intravenous injection;Investigation;Knowledge;Link;Malignant Neoplasms;Mammary Neoplasms;Mammary Tumorigenesis;Mediating;Mitochondria;Molecular;Molecular Analysis;mortality;Necrosis;Neoplasm Metastasis;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Nude Mice;Organ;Outcome;Pathway interactions;Patients;Phosphotransferases;Prognosis;programs;Protein Kinase Interaction;Proteins;Reactive Oxygen Species;Receptor Inhibition;Receptor Signaling;Receptor-Interacting Protein;Regulation;Role;Signal Transduction;Therapeutic;therapeutic development;Therapeutic Intervention;tumor;tumor progression;Tumor stage;tumorigenesis

PROJECT_TITLE: Mitophagy-Mediated Cell Death in Mammary Tumorigenesis


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE This proposal aims to enhance the Hmong ethnic minority involvement in cancer preventative screenings. It seeks to boost awareness and knowledge regarding cancer prevention among Hmong communities in California, particularly those facing persistent poverty, while encouraging their participation in early detection screenings and assessing income intervention such as the earned income tax credit. This proposal for Diversity Supplement will allow Ms. April Vang, under supervision and mentored by Dr. Carvajal-Carmona, to investigate the association between key social needs and colorectal cancer screenings in the California Hmong population.

PI_NAMEs: BONDY, MELISSA L.;CARVAJAL CARMONA, LUIS GUILLERMO;GRUSKY, DAVID B;HIATT, ROBERT A;REHKOPF, DAVID H (contact)

PROGRAM_OFFICER_NAME: HARDESTY, REBECCA ANNE

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Affect;Area;Awareness;Behavior;bilingualism;California;Cancer Burden;Cancer Control;Cancer Etiology;Cancer health equity;cancer prevention;Cancer Science;career;career development;Catchment Area;Cities;Collaborations;Colorectal Cancer;colorectal cancer prevention;colorectal cancer screening;Communities;Community Outreach;community partners;County;Data Scientist;deprivation;Development;Early Diagnosis;ethnic minority;Event;Face;Food;Grant;Health;Health Fairs;Healthcare Systems;Housing;improved;Incidence;Income;Income Tax;Individual;Inequity;innovation;Intervention;Knowledge;Malignant Neoplasms;mathematical model;Mediating;member;Mentors;Neighborhoods;neoplasm registry;Outcome;Parents;Pilot Projects;Policy Maker;Policy Making;Population;Poverty;Poverty Areas;prevent;Prevention;Prevention Measures;Preventive screening;programs;recruit;Research;Research Personnel;Research Project Grants;Resources;Sample Size;screening;social;social determinants;social health determinants;Social Sciences;Source;stem;structural determinants;Supervision;Training;Transportation

PROJECT_TITLE: The Upstream Center: Income Interventions to Address the Fundamental Causes of Cancer Inequities


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Nutrition;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Although pancreatic ductal adenocarcinoma (PDAC) can alter the mRNA translation efficiency (mTE) of codons in response to severe nutrient-depleted environments to selectively synthesize proteins required for adaptation and tumorigenesis, we still do not understand the pathways that regulate this process in human cancers. This proposal aims to decipher the signaling cascades and mechanisms that regulate the mRNA translation efficiencies of Ser codons upon Ser-starvation, and to target these pathways during PDAC tumorigenesis. The findings from this work will have a profound impact on our fundamental understanding of the pathways and mechanisms that regulate the mTE of Ser codons, identify a therapeutic vulnerability in the adaptation to Ser-starvation in PDAC, and can greatly shift our perception of the effects of codon regulatory pathways in human health and disease.

PI_NAMEs: BANH, ROBERT SINGHUNG (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Amino Acids;beta-2 Microglobulin;biochemical model;Biological Assay;Biological Models;Biology;Breast;Cancer Patient;Candidate Disease Gene;Cell Cycle;Cell Cycle Arrest;Cell surface;Cells;Charge;Codon Nucleotides;Complex;CRISPR screen;Cyclin-Dependent Kinases;deprivation;Diet;dietary;dietary restriction;Disease;Environment;Enzymes;Genes;Genetic Diseases;Genetic Transcription;Glycine;Growth;Health;Human;Human Genetics;Hypoxia;Immune;Immunocompetent;immunodeficiency;Immunofluorescence Immunologic;Impairment;improved outcome;Initiator Codon;insight;Intellectual functioning disability;Intervention;KPC model;Major Histocompatibility Complex;Major Histocompatibility Complex Gene;Malignant Neoplasms;Measures;Melanoma;molecular modeling;mouse model;mRNA Translation;Mus;mutant;Mutation;Nerve;Nerve Growth Factors;nerve supply;novel therapeutic intervention;novel therapeutics;Nuclear;Nutrient;Nutrient Depletion;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;pancreatic tumorigenesis;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Perception;Perfusion;Phosphorylation;preference;prevent;Process;Production;Prognosis;Protein Biosynthesis;Proteins;Proteome;Proteomics;Regulation;Regulatory Pathway;Reporter;Research;Resistance;response;ribosome profiling;Role;Serine;serine-tRNA;Signal Pathway;Signal Transduction;Spatial Distribution;Starvation;Therapeutic;Transfer RNA;Translation Initiation;tRNA Precursor;tumor;tumor ablation;Tumor Burden;tumorigenesis;Western Blotting;whole genome;Work

PROJECT_TITLE: Elucidating The Adaptive Role Of Serine Codons During Pancreatic Tumorigenesis - Diversity Supplement


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE Malignant phyllodes tumors are aggressive breast neoplasms, which have disproportionately high local recurrence and metastatic rates, and afflict very young women. With limited ability to predict outcomes and no known effective systemic therapy options, metastatic progression portends a truly dismal prognosis. This research will provide an improved ability to predict risk of recurrence and define clinically actionable opportunities for this rare, but frequently fatal, tumor.

PI_NAMEs: ROSENBERGER, LAURA HORST (contact)

PROGRAM_OFFICER_NAME: ZINN, REBEKAH

PROJECT_TITLE: Defining Actionable Opportunities in Malignant Phyllodes via Genomic Profiling

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CFSN-T (01)]


NIH_SPENDING_CATS: Bioengineering;Cancer;Immunotherapy

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: The project aims to understand how different types of immune cells transfer mitochondria to cancer cells through physical nanoscale tentacles called nanotubes, and whether blocking these tubes can improve cancer responses to immunotherapies. Here, I will develop 2D and 3D models to observe how these mitochondria transfers between cancer and immune cells alter cancer cell behaviors. The ultimate goal is to evaluate the efficacy and safety of the new drugs in the proposed bioengineered models, to make existing cancer immunotherapies more effective.

PI_NAMEs: SENGUPTA, SHILADITYA  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: 3-Dimensional;Address;Advanced Malignant Neoplasm;Affect;anti-cancer;Biomedical Engineering;cancer cell;cancer immunotherapy;cell behavior;Cell Communication;Cells;Characteristics;checkpoint therapy;Complex;Development;Effectiveness;effectiveness evaluation;efficacy evaluation;Environment;Extracellular Matrix;Goals;Immune;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immunotherapy;improved;inhibitor;insight;Knowledge;Macrophage;Malignant Neoplasms;Mediating;Mitochondria;Modeling;nanoscale;Nanotubes;novel;novel therapeutics;parent grant;Phenotype;Physiological;prevent;Process;Property;Research;Research Design;response;Role;Safety;Structure;Study models;targeted treatment;Testing;three-dimensional modeling;trafficking;Tube

PROJECT_TITLE: Investigating nanotube-mediated mitochondria transfer and inhibitor effects in cancer-immune cell interactions across 2D and 3D models

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Mental Health;Mental Illness;Patient Safety;Prevention;Serious Mental Illness;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: HADLEY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE  Suicide research has faltered in identifying short-term predictors of suicide risk and studies such as the parent study face unique challenges in the need to overrecruit from a population that faces unique adversities (e.g., suicidal crises, low resources, and housing instabilities). The proposed supplement seeks to leverage the research to identify suicide risk markers in this vulnerable population by (1) improving our power to detect effects, (2) improving suicide research by identifying how suicidologists can effectively manage risk, and (3) addressing early implementation considerations for how we can best provide suicide prevention and care to vulnerable populations. NIH’s mission will be served by the proposed supplement through improving the prediction of suicidal behaviors in high-risk populations, improving future suicide research, and informing prevention efforts, ultimately reducing suffering and mortality with substantial societal cost.

PI_NAMEs: DIXON-GORDON, KATHERINE LEE (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Accident and Emergency department;Accounting;Address;Caring;Cause of Death;Cessation of life;Clinical;Data;Decision Making;Distal;Ecological momentary assessment;Emergency Department patient;Emotional;Emotions;Enrollment;Evaluation;experience;Face;Feeling suicidal;financial incentive;Future;high risk population;housing instability;improved;Intervention;Interview;Learning;Low income;Methods;Minority;Mission;mortality;mortality risk;Parents;Participant;participant enrollment;Patients;Persons;Population;power analysis;Prevention;Protocols documentation;Psychiatric therapeutic procedure;Psychological reinforcement;Research;research study;Resources;response;Risk Assessment;Risk Factors;Risk Management;Risk Marker;Sample Size;societal costs;suicidal;suicidal act;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;Surveys;United States National Institutes of Health;Vulnerable Populations

PROJECT_TITLE: EMERGE: Ecological Momentary Evaluation of Responses to Gain/Loss and Emotions


PHR: Narrative This administrative supplement will allow Ms. Abigail Monroy Duenas to complete a Fast-track Master’s degree under the mentorship of Drs Lacreuse and Vazey. She will be trained to use immunohistochemistry in marmoset brain tissue to better understand how the aromatase inhibitor letrozole and the brain-selective estrogen DHED affect behavior in primates.

PI_NAMEs: LACREUSE, AGNES  (contact);MERCHENTHALER, ISTVAN JOZSEF;PROKAI, LASZLO

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Administrative Supplement;Affect;aging brain;Aromatase;Aromatase Inhibitors;Behavior;Brain;brain tissue;Callithrix;Cognition;Data;Electrophysiology (science);Estrogen Receptors;Estrogens;Female;Gene Expression;Goals;Hippocampus;Hypothalamic structure;Immunohistochemistry;Letrozole;male;Master of Science;Mentorship;Molecular;nonhuman primate;parent grant;Prefrontal Cortex;Primates;Prodrugs;Proteins;skills;Spatial Distribution;Training;women's treatment

PROJECT_TITLE: Impact of brain estrogens on cognition and brain aging in a non-human primate


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Lung;Lung Cancer;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Cancer therapies often fail because the target they inhibit is needed in normal cells. This problem manifests as toxicity in the clinic, and results in lowering the doses of the drug to levels that lose efficacy in the cancer. We have discovered a generalizable way to improve therapeutic index in cancer by taking advantage of dysregulated Iron (Fe2+) handling, a feature we find to be an early and prominent effect of RAS signaling in many malignancies.

PI_NAMEs: COLLISSON, ERIC  (contact);RENSLO, ADAM R

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Adult;Alkylating Agents;anti-cancer;anti-cancer therapeutic;Anti-malarials;Antineoplastic Agents;Area;Avidity;biomarker development;cancer cell;Cancer Patient;cancer therapy;cell transformation;Cells;Cessation of life;Chemistry;Clinic;Clinical;Colorectal Cancer;cost;Cytotoxic agent;Dangerousness;Development;DNA;Dose;Drug Delivery Systems;drug development;Drug resistance;Drug Tolerance;efficacy validation;Enzymes;Exposure to;FDA approved;flexibility;Foundations;Frustration;Genetically Engineered Mouse;Growth;Hepatotoxicity;Human;human subject;Immune checkpoint inhibitor;Immunocompetent;improved;in vivo;inhibitor;innovation;invention;Iron;kinase inhibitor;KRAS2 gene;KRASG12D;Left;Lung Adenocarcinoma;Malignant - descriptor;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant phenotype;MAP Kinase Gene;Maximum Tolerated Dose;Medical;Medical Oncologist;MEK inhibition;MEKs;Metabolic;Methods;Modality;Modeling;Molecular Target;mouse model;Mutation;neoplastic cell;Normal Cell;novel;novel strategies;novel therapeutics;Oncogenes;Oncogenic;Oncology;Oxidation-Reduction;Pancreatic Adenocarcinoma;Pancreatic Ductal Adenocarcinoma;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;pre-clinical;Pre-Clinical Model;precision oncology;Predisposition;preservation;pressure;Process;Prodrugs;Productivity;Proliferating;Property;screening;Selection for Treatments;Signal Transduction;small molecule;Solid Neoplasm;success;targeted agent;Technology;Therapeutic;Therapeutic Index;Tissues;Toxic effect;Treatment Efficacy;tumor;Work

PROJECT_TITLE: Understanding efficacy and FE(II)-Promoted Activation of 1,2,4-Trioxolanes in cancer

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: FLAGSTAFF

ORG_DEPT: MISCELLANEOUS

ORG_NAME: NORTHERN ARIZONA UNIVERSITY

ORG_STATE: AZ

PHR: PROJECT NARRATIVE This project will address two specific goals of the National Institutes of Health Data Science Strategic Plan, including the National Institute on Minority Health and Health Disparities initiatives regarding the use of the Science Collaborative for Health Disparities and Artificial Intelligence Bias Reduction data platform. We aim to 1) expand the institutional workforce by hiring a new data scientist and 2) broaden the utility of, access to, and sustainable structures to support specialized tools through the proposed Data Science Skills Workshop series, and by mentoring doctoral and undergraduate students in the All of Us dataset, ultimately increasing data science capacity at the University.

PI_NAMEs: BALDWIN, JULIE ANN (contact)

PROGRAM_OFFICER_NAME: JOSEPH, SUSAN KALAPURA

PROJECT_TERMS: Academy;Address;All of Us Research Program;analytical tool;Area;Arizona;Artificial Intelligence;Big Data;biomedical data science;Biometry;Clinical;Collaborations;college;Communities;community partners;complex data;Data;Data Analyses;Data Analytics;Data Collection;data platform;Data Reporting;Data Science;data science infrastructure;Data Scientist;Data Set;data standards;Development;digital;Doctor of Philosophy;doctoral student;Education;Educational Curriculum;Educational workshop;Exposure to;Faculty;faculty support;Fostering;Foundations;Funding;Geographic Information Systems;Goals;Grant;Health;Health Disparities Research;health disparity;health equity;Health equity research;health inequalities;Hispanic;improved;improved outcome;Indigenous;Infrastructure;Institution;Interdisciplinary Study;interest;Investigation;Knowledge;large datasets;Medicine;member;Mentors;Methodology;Methods;Minority Groups;minority health;Minority-Serving Institution;National Institute on Minority Health and Health Disparities;Outcome;Population Heterogeneity;programs;Pythons;rapid growth;Research;Research Design;Research Infrastructure;Research Personnel;Research Support;Science;Secure;Series;Services;skills;Strategic Planning;Structure;Techniques;Technology;tool;Training;undergraduate student;Underrepresented Students;Underserved Population;United States National Institutes of Health;United States National Library of Medicine;Universities;Work

PROJECT_TITLE: Southwest Health Equity Research Collaborative (SHERC)


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Telehealth

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE This study will evaluate the ability of a targeted eHealth parent-directed intervention to reduce the burden of cancer survivorship by improving psychosocial and behavioral outcomes in the underserved population of childhood leukemia and lymphoblastic lymphoma survivors. We anticipate that leveraging digital health solutions will produce an effective, scalable therapy that overcomes key barriers to follow-up care and is easily integrated into care delivery.

PI_NAMEs: PATEL, SUNITA K (contact)

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: Acute Lymphocytic Leukemia;Address;Adult;adverse outcome;Award;behavioral outcome;Brain;California;Cancer Burden;Cancer Center;Cancer Survivor;Cancer Survivorship;cancer therapy;care delivery;Caring;Central Nervous System;Child;Child Behavior;Childhood Brain Neoplasm;childhood cancer survivor;Childhood Leukemia;Cities;cognitive function;comparative efficacy;design;Development;Diagnosis;digital health;Disparity;E-learning;Education;educational atmosphere;Educational Intervention;Educational process of instructing;effective therapy;effectiveness evaluation;eHealth;Eligibility Determination;Enrollment;Environment;experience;Family;Feedback;follow-up;functional outcomes;Goals;Habits;Health;health care delivery;Health Disparities Research;health disparity;Health Insurance Portability and Accountability Act;health related quality of life;Health Technology;high risk;Impairment;improved;innovation;insight;Intervention;intervention program;Language;Late Effects;Latino;Learning;learning strategy;leukemia;leukemia/lymphoma;Link;Long-Term Care;Los Angeles;low socioeconomic status;Lymphoblastic Lymphoma;Malignant Childhood Neoplasm;Medical center;medically underserved population;meetings;Monitor;Multimedia;Neurocognition;Neurocognitive;Neuropsychological Tests;online resource;Online Systems;Outcome;outcome disparities;parental involvement;Parents;Patient Self-Report;Patients;Pediatric Hospitals;Pediatric Oncologist;Performance;Persons;Phase;pilot trial;Population;prevent;programs;psychosocial;psychosocial outcome;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Research;Risk;routine care;Schedule;Schools;Shapes;Site;skills;social;sociodemographic group;Socioeconomic Status;Spanish/English;Special Education;standard care;stress management;success;Survivors;Technology;telehealth;Test Result;Testing;Time;tool;Toxic effect;Training;Travel;treatment as usual;Treatment Side Effects;Underserved Population;Unemployment;uptake;Videoconferencing;web site

PROJECT_TITLE: Leveraging Digital Health Solutions to Reduce Learning and Functional Disparities in Children with Cancer - Diversity Supplement


NIH_SPENDING_CATS: Cachexia;Cancer;Clinical Research

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PI_NAMEs: INFANTE, RODNEY E (contact);IYENGAR, PUNEETH

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: Adipose tissue;Cancer Cachexia;cellular targeting;Molecular Target;wasting

PROJECT_TITLE: Identifying the Cellular and Molecular Targets of JAK/STAT-Driven Adipose Wasting to Reverse Cancer Cachexia

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_NAME: BLOODWORKS

PHR: Project Narrative: Chronic inflammatory conditions such as aging and Rheumatoid Arthritis are associated with a high risk for thrombotic events. We hypothesis that chronic inflammation promotes platelet hyperreactivity and thrombosis in these populations. Therefore, we propose to study the mechanisms that underlay inflammation-associated platelet hyperreactivity.

PI_NAMEs: DAVIZON-CASTILLO, PAVEL  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Adult;Advisory Committees;Aging;aging related disease;analytical method;Area;atherothrombosis;Autophagocytosis;Award;Big Data;Biochemical;Biology;Blood Platelets;Cardiovascular Diseases;career;career development;Career Transition Award;Caring;Child;Chronic;Chronic Childhood Arthritis;clinically relevant;Coagulation Process;Coronary Circulation;cost estimate;Data;Data Analyses;Dedications;Development;Development Plans;Disease;Doctor of Philosophy;Elements;Environment;Event;experience;Flow Cytometry;Foundations;Functional disorder;Funding;Future;Goals;high risk;Human;human old age (65+);Impairment;improved;Incidence;Individual;Inflammation;Inflammatory;inorganic phosphate;Investigation;Mediating;Megakaryocytes;Mentors;Mentorship;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Microscopy;Mitochondria;Molecular;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Mus;novel;novel therapeutic intervention;older adult;older patient;Older Population;Outcome;Pathway interactions;Patients;Pediatrics;Pentosephosphate Pathway;pharmacologic;Phase;Physicians;platelet function;Population;Populations at Risk;Productivity;professor;programs;Publishing;Records;recruit;Regulation;Research;Research Personnel;Rheumatoid Arthritis;Ribosomes;Role;Scientist;Sickle Cell Anemia;skills;skills training;Solid;stem;Stroke;Technical Expertise;Thrombosis;thrombotic;Thrombus;TNF gene;tool;Training;transcriptomics;Translational Research;Work

PROJECT_TITLE: Inflammation-mediated platelet hyperreactivity and thrombosis


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Infectious Diseases;Networking and Information Technology R&D (NITRD);Rare Diseases;Telehealth

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Trachoma is the leading infectious cause of blindness in the world. This project aims to develop a mobile software application to enhance trachoma monitoring activities by allowing eye photography and integration of visual acuity and refractive error assessment. The mobile application will be field-tested and validated in diverse settings in Peru to ensure broad generalizability.

PI_NAMEs: KEENAN, JEREMY DAVID (contact);LESCANO, ANDRES G

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3D Print;Address;Adopted;Affect;Anterior;Area;automated algorithm;Blindness;California;Cellular Phone;Certification;Child;Chlamydia trachomatis;Clinical;Collaborations;Communities;Computer software;Cornea;Data;Data Collection;data platform;Development;Diagnosis;Diagnostic tests;Ensure;experience;Eye;feasibility testing;field study;fighting;flexibility;Foundations;Goals;Health;Health Personnel;Health Resources;Health Surveys;Hospitals;Human;Human Resources;imaging Segmentation;Individual;Lighting;Location;mobile application;Modality;Modeling;Monitor;neglected tropical diseases;ophthalmic examination;Pan American Health Organization;Participant;Persons;Peru;Photography;population based;Printing;programs;Public Health;Questionnaires;Recommendation;Refractive Errors;remote communities;remote grading;Research;Research Personnel;Resource-limited setting;sample collection;Sampling;San Francisco;Sensitivity and Specificity;Structure;success;Surveys;System;Telemedicine;Testing;tool;Trachoma;Universities;Update;uptake;user-friendly;validation studies;Variant;Vision Screening;Visual Acuity;Work;World Health Organization

PROJECT_TITLE: Integrating smartphone photography for trachoma, smartphone visual acuity assessment, and mobile autorefraction to enhance community-based public health monitoring - Diversity Supplement


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Even though smoking in pregnancy harms the baby, pregnant women struggle to quit smoking. We are coupling a texting program that helps pregnant women quit with a program to teach obstetric clinicians how to counsel women to quit. We expect that women will be most likely to quit when they receive both the texting and are counseled by a clinician who has learned effective communication.

PI_NAMEs: CHANG, JUDY C;POLLAK, KATHRYN I (contact)

PROGRAM_OFFICER_NAME: LAND, STEPHANIE R

PROJECT_TERMS: Abstinence;Affect;arm;Biochemical;Birth;Clip;Communication;Communication Programs;comparison control;cost;Counseling;Coupling;design;Discipline of obstetrics;Double Effect;Educational process of instructing;Equation;Evidence based intervention;Exercise;expectation;Feedback;Guidelines;Health Care Costs;improved;Individual;individualized feedback;Infant Care;infant morbidity/mortality;Infant Mortality;Intervention;intervention effect;Learning;Light;Low Birth Weight Infant;maternal morbidity;Meta-Analysis;Modeling;Mothers;neonatal morbidity;Oncologist;Online Systems;Outcome;Outcome Assessment;Patients;pediatrician;Perception;Perinatal;Phase;pilot test;post intervention;Postpartum Abstinence;Postpartum Period;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;primary outcome;programs;Public Health;Randomized;Randomized, Controlled Trials;recruit;Reporting;secondary outcome;Self Efficacy;Site;skills;Smoke;Smoking;smoking abstinence;smoking cessation;smoking during pregnancy;Suggestion;Testing;Text;Text Messaging;text messaging intervention;theories;Touch sensation;Training;Training Programs;treatment arm;United States;web-based intervention;Woman;Work

PROJECT_TITLE: Relationship of bias and negative birth outcomes

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: PROJECT NARRATIVE OF PARENT GRANT This research focuses on acute myeloid leukemia (AML), which affects more than 10,000 Americans annually, the majority of who die of their disease within a short time. This research addresses the role of aberrant RAS signaling in relapsed/refractory AML and the efficacy of Mediator/RNA Pol II targeting as novel treatment strategy. The overall goal of this work is to establish new and effective strategies to treat relapsed/refractory AML.

PI_NAMEs: SMITH, CATHERINE CHOY (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Affect;American;BCL2 gene;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Combined Modality Therapy;Dependence;Disease;DNA Polymerase II;efficacy evaluation;FLT3 gene;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide;Goals;improved;In Vitro;in vivo;Induction of Apoptosis;inhibitor;inhibitor therapy;Isocitrate Dehydrogenase;Leukemic Cell;Link;Malignant Neoplasms;Mediating;Mediator;Methods;Mitogen-Activated Protein Kinases;mutant;Mutate;Mutation;new therapeutic target;Newly Diagnosed;non-genetic;novel;novel strategies;novel therapeutics;Oncogenic;parent grant;Pathway interactions;Patients;Pattern;Phosphorylation;Phosphotransferases;Pre-Clinical Model;programs;Recurrence;Refractory;Regulatory Element;Relapse;relapse patients;Research;Research Project Grants;Resistance;Resistance development;resistance mechanism;response;RNA;RNA Polymerase II;Role;Sampling;Signal Transduction;small molecule inhibitor;targeted treatment;Therapeutic;therapeutic target;therapeutically effective;therapy resistant;Time;Transcription Coactivator;Transcription Factor AP-1;Translating;treatment strategy;Tyrosine Kinase Inhibitor;Up-Regulation;Work

PROJECT_TITLE: RNA Polymerase II as a Therapeutic Target in Acute Myeloid Leukemia (AML) with RAS Signaling Activation

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: Project Narrative The proposed research seeks to test the hypothesis that increased interferon (IFN) signaling is a common phenomenon in non-transformed B cells from carriers of p53 hypomorphs, compared to WT p53 or benign variants. The proposed research seeks to determine the mechanism underlying increased IFN signaling, and test the hypothesis that increased IFN signaling is a biomarker for hypomorphic p53.

PI_NAMEs: MURPHY, MAUREEN E. (contact)

PROJECT_TERMS: Adopted;Affect;Alleles;Apoptosis;B lymphocyte immortalization;B-Lymphocytes;Benign;Biological Markers;cancer risk;Categories;Cell Cycle Arrest;Cell Line;Cells;chemotherapy;Classification;Clinical Trials Design;Data;Defect;Disease;Double-Stranded RNA;ds-DNA;Elements;Endogenous Retroviruses;Etiology;Family;gain of function;Gene Expression Profile;Genetic;Genetic Databases;genetic signature;Genetic Transcription;genetic variant;Germ Lines;Germ-Line Mutation;Goals;graduate student;Heterozygote;Human;Human Cell Line;immunogenic cell death;Impairment;improved;Individual;Inherited;Interferon Activation;Interferons;Laboratories;Li-Fraumeni Syndrome;Life;lymphoblast;Magnetic Resonance Imaging;Malignant Neoplasms;Medical Genetics;micronucleus;Mitochondria;Mitochondrial DNA;Molecular Conformation;mouse model;Mus;mutant;Mutation;NF-kappa B;Oncogenic;Outcome;Parents;Pathway interactions;Patients;Pennsylvania;Persons;Predisposition;Prognosis;Proliferating;protein expression;Proteomics;Publications;Repression;Research;screening;Screening for cancer;senescence;Siblings;Signal Pathway;Signal Transduction;Stimulator of Interferon Genes;Talents;Testing;The Wistar Institute;TLR3 gene;TP53 gene;Training;transcriptome sequencing;tumor;Tumor Suppression;United States;university student;Variant;variant of unknown significance

PROJECT_TITLE: The genetics of tumor suppression by p53 - Diversity Supplement


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE [parent project] State of the art methods for the early detection and monitoring of cancer are either invasive, time-consuming, expensive, or frequently inaccurate, which hinders the routine screening of at risk-patients to improve survival rates. Here, we propose a portable neural network enabled spectroscopy platform to diagnose cancer in patient biofluids (saliva, blood plasma, and sweat). The expected outcome is to deliver a novel point of care liquid biopsy platform to better classify, monitor, and improve diagnostic sensitivity of a broad range of diseases and conditions, with focus on early/late-stage head and neck cancer.

PI_NAMEs: CARNEY, RANDY ;GOMEZ DIAZ, JUAN SEBASTIAN  (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: absorption;accurate diagnostics;Address;Algorithms;Benign;Biological Markers;Biopsy;Biosensor;Blinded;Blood;Calibration;Cancer Control;Cancer Detection;cancer diagnosis;cancer type;circulating biomarkers;Classification;Clinical;clinical diagnosis;cohort;Complex;Computer software;Consumption;Data;data streams;deep neural network;design;Detection;detection limit;detector;Devices;Diabetes Mellitus;Diagnosis;Diagnostic;Diagnostic Sensitivity;Disease;Dryness;Early Diagnosis;Economics;effective therapy;Electromagnetics;Elements;Fingerprint;Foundations;Fourier Transform;Fourier transform infrared spectrometry;Future;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;Head and Neck Surgery;Health Status;Heart Diseases;Heterogeneity;high reward;high risk;Histopathology;Image;imaging modality;Immunohistochemistry;improved;improved outcome;Individual;infrared spectroscopy;innovation;interdisciplinary approach;Interferometry;Label;learning network;Libraries;Light;liquid biopsy;Liquid substance;Machine Learning;machine learning algorithm;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Metabolic;Metabolic Diseases;metabolomics;Methods;miniaturize;Modeling;Monitor;Monitoring for Recurrence;multidisciplinary;multiplex detection;nano;nanopattern;Neck Cancer;neural network;neural network architecture;Neural Network Simulation;novel;Otolaryngology;Outcome;Output;parent project;Pathology;patient stratification;Patients;Performance;Plasma;plasmonics;point of care;portability;Process;Raman Spectrum Analysis;Rapid diagnostics;rapid testing;Recurrence;Risk;routine screening;Saliva;Sampling;segregation;sensor;Signal Transduction;smartphone application;Solid;Specificity;Spectroscopy, Fourier Transform Infrared;Spectrum Analysis;Spottings;Staging;Statistical Data Interpretation;Survival Rate;System;Techniques;Technology;Testing;Time;tool;Translating;Update;voltage;wearable device;Width;Work

PROJECT_TITLE: Neural-network enabled nano-spectroscopy for label-free cancer detection in biofluids

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Human genetic variants impacting B cell function and the production of pathogenic antibodies against self (termed autoantibodies) contribute to the pathogenesis of systemic lupus erythematosus (SLE), a chronic, multi- system autoimmune disease. This Diversity Supplement will support the scientific training in B cell biology of a research scientist from a background underrepresented in medicine (URM). The long-term goal of these studies is to guide the development of new targeted therapies for the treatment of SLE.

PI_NAMEs: JACKSON, SHAUN WILLIAM (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Antibodies;Apoptotic;Autoantibodies;Autoimmune Diseases;Autoimmunity;Autophagocytosis;autoreactive B cell;B-Cell Activation;B-Lymphocytes;Biochemical;career;Cell Physiology;Cellular biology;cellular imaging;Chronic;clinically relevant;Complex;Data;Defect;Development;disorder risk;Endosomes;Generations;Genes;Genetic Models;genetic variant;genome wide association study;Goals;Human;Human Genetics;imaging approach;Immune;Immune Tolerance;In Vitro;in vivo;Individual;insight;Link;loss of function;loss of function mutation;Lupus;Medicine;Modeling;Mus;Myelogenous;NADPH Oxidase;new therapeutic target;Oxidases;Pathogenesis;pathogenic autoantibodies;Pathogenicity;Pathway interactions;Phagocytes;Production;Publishing;Research;Research Proposals;response;Risk;Scientist;Signal Transduction;Structure of germinal center of lymph node;System;Systemic Lupus Erythematosus;Testing;TLR7 gene;Toll-like receptors;trafficking;Training;Variant;Virus Diseases;Wiskott-Aldrich syndrome protein

PROJECT_TITLE: Impact of Loss-of-function NADPH Oxidase Variants on B-Cell Activation in SLE


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative The ubiquitin E3 ligase, UBR5 is one of the most commonly mutated genes (~18%) in mantle cell lymphoma (MCL) with the majority of mutations identified in UBR5 were frame shift mutations found within the HECT domain. Here we will study the molecular function of ubiquitin E3 ligase, UBR5 mutations in lymphomagensis. Deciphering the role of the UBR5 and pathways dysregulated by mutations in mantle cell lymphoma will provide clues to lymphoma transformation with the goal of identifying targets for future therapeutics.

PI_NAMEs: BUCKLEY, SHANNON  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: B-Lymphocyte Subsets;B-Lymphocytes;Bodily secretions;Cell Maturation;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Development;Disease Progression;Frameshift Mutation;Future;Genes;Goals;insight;lymph nodes;Lymphoid;Lymphoma;Lymphomagenesis;Mantle Cell Lymphoma;Mantle Zone;Messenger RNA;Molecular;multicatalytic endopeptidase complex;Mus;Mutate;Mutation;next generation sequencing;Non-Hodgkin's Lymphoma;novel;overexpression;Pathway interactions;Patients;Phenotype;Plasma Cells;Proliferating;protein degradation;Proteins;Proteomics;RNA Splicing;Role;Spleen;Spliceosomes;Structure of germinal center of lymph node;System;Technology;Therapeutic;therapeutic target;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Up-Regulation

PROJECT_TITLE: Role of ubiquitin ligases in mantle cell lymphoma

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Bioengineering;Biotechnology;Chronic Pain;Gene Therapy;Genetics;Immunotherapy;Pain Research;Regenerative Medicine;Rheumatoid Arthritis;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The goals of this project are to combine synthetic biology and tissue engineering to create therapeutic cells that can produce biologic drugs on demand. These cells will be implanted in vivo to determine their ability to treat rheumatoid arthritis by providing long-term, feedback control of different biologic drugs.

PI_NAMEs: GUILAK, FARSHID  (contact);PHAM, CHRISTINE T.

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Acute;Adult;Adverse effects;Adverse event;Amplifiers;anakinra;Anti-Cytokine Therapy;Anti-Inflammatory Agents;Arthritis;arthritis therapy;Autoimmune Diseases;behavior test;Biological;Biological Products;Biological Response Modifier Therapy;biomaterial compatibility;bone erosion;cancer type;Cell Physiology;Cell Therapy;Cells;Chemical Dynamics;Chronic;Chronic Disease;chronic inflammatory disease;Clinical;clinical translation;collagen antibody induced arthritis;Collagen Arthritis;Complex;CRISPR/Cas technology;Cues;Custom;cytokine;design;Development;disability;Disabling;Disease;Dose;Drug Delivery Systems;drug production;efficacy testing;Encapsulated;engineered stem cells;Engineering;Environment;Exhibits;Feedback;Genes;Genetic;Genetic Engineering;Genetic Transcription;Genome engineering;Goals;Histologic;IL6ST gene;Implant;implantation;In Vitro;in vivo;in vivo evaluation;Induction of Apoptosis;Infection;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;Injections;innovation;Interleukin-1;Interleukin-6;joint destruction;K/BxN model;Methods;Modeling;Molecular;mouse model;Mus;Musculoskeletal;next generation;Output;Pain;Pain Measurement;Patients;personalized medicine;Pharmaceutical Preparations;Predisposition;Prevalence;prevent;Process;Production;programs;receptor;Regenerative Medicine;response;Rheumatoid Arthritis;Risk;Safety;safety engineering;scaffold;Sensitivity and Specificity;Sepharose;Serum;Severities;stem cell based approach;stem cell biology;stem cells;subcutaneous;success;Suicide;Swelling;synthetic biology;Synthetic Genes;System;systemic inflammatory response;Testing;Therapeutic;Time;Tissue Engineering;Tissues;TNF gene;TNFRSF1A gene;Translations;Treatment Efficacy;Work

PROJECT_TITLE: Genetically-engineered stem cells for self-regulating arthritis therapy

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: SILVER SPRING

ORG_NAME: SOCIAL AND SCIENTIFIC SYSTEMS,  INC.

ORG_STATE: MD

PI_NAMEs: ABRAHAM, SAKHI  (contact)

PROJECT_TERMS: Air;Aliquot;Archives;Biological;Biological Assay;Blinded;Body Fluids;Cell Count;Cell Separation;Collection;Contractor;Contracts;cost;Cryopreservation;Data;Database Management Systems;Databases;Development;DNA;Dust;environmental transport;Epidemiology;Equipment;Equipment and supply inventories;field study;Guidelines;Inherited;Institution;Laboratories;Liquid substance;Maintenance;Maryland;meetings;Monitor;Movement;National Institute of Environmental Health Sciences;Nitrogen;operation;Phase;Preventive;Procedures;Process;Protocols documentation;quality assurance;Regulation;repaired;Reporting;Research;Research Personnel;Safety;sample collection;Sampling;Services;Silver;Soil;Specific qualifier value;Specimen;Testing;Tissues;Training;Urinalysis;vapor;Water;web portal

PROJECT_TITLE: TO3R: SPECIMENS


NIH_SPENDING_CATS: Burden of Illness;Cancer;Prevention;Social Determinants of Health

PI_NAMEs: SCHWARTZ, PHD, STEPHEN  (contact)

PROJECT_TERMS: Annual Reports;anti-cancer research;Cancer Control;Cancer Patient;cancer statistics;Data;Diagnosis;Disease;Geography;Incidence;Infrastructure;insight;Malignant Neoplasms;Monitor;National Cancer Institute;Patients;Population;Prevalence;SEER Program;Social Characteristics;Subgroup;Time;treatment pattern;trend

PROJECT_TITLE: SEER CORE INFRASTRUCTURE SUPPORT


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Many VA patients receive long-term opioid therapy (LTOT). LTOT may be harmful, and so physicians are supposed to frequently monitor LTOT patients. However, many LTOT patients are not frequently monitored, and many are having LTOT discontinued, even though discontinuation may also be harmful. Because of potential harms of LTOT, difficulties of frequent monitoring, and potential harms of having LTOT discontinued, physicians need practical tools and guidelines to improve care. This project will improve patient care by developing integrated screening tools to indicate if LTOT is harmful to continue (yes or no), and if tapering to discontinue opioids is harmful to initiate (yes or no). When the tool indicates “yes,” this will mean that physicians should start additional, more comprehensive monitoring and examination to determine the harms and benefits of continued LTOT or of tapering to discontinuation. This project will also identify preliminary treatment approaches for an at-risk subgroup of LTOT patients: those who screen “yes” on both tools.

PI_NAMEs: BRELAND, JESSICA YELENA (contact);HOGGATT, KATHERINE JOANN

PROJECT_TERMS: Activities of Daily Living;Acute;Address;Adherence;alternative treatment;Behavior;Caring;Clinic;Clinical;Clinical Practice Guideline;cognitive interview;comorbidity;coping;cost;Dangerousness;Data;data warehouse;Decision Making;Diagnosis;Doctor of Philosophy;Electronic Health Record;Emergency department visit;Feeling suicidal;field study;Focus Groups;follow-up;Goals;Guidelines;Harm Reduction;health care settings;Healthcare;Healthcare Systems;Heroin;Hospitalization;improved;innovation;instrument;integrated care;Link;Measures;medication-assisted treatment;Mental Health;Mental Health Services;Methods;Modeling;Monitor;non-opioid analgesic;operation;Opioid;opioid mortality;opioid tapering;opioid therapy;opioid use disorder;Overdose;overdose death;pain catastrophizing;Pain Clinics;Pain management;Patient Care;Patient Monitoring;patient oriented;patient subsets;Patient-Centered Care;Patient-Focused Outcomes;Patients;Physicians;Policies;Practice Guidelines;prescription opioid;Prevalence;Primary Care;Program Evaluation;programs;Provider;Recommendation;Research;Resources;response;Risk;Screening procedure;Self Direction;side effect;Site;Subgroup;substance use;Substance Use Disorder;suicidal;suicide rate;Surveys;systematic review;Telephone;Testing;text searching;therapy development;tool;Veterans;Veterans Health Administration;Violence;Withdrawal Symptom;Work

PROJECT_TITLE: Long-Term Opioid Therapy: Screen to Evaluate and Treat (Opioid-SET)

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ORG_CITY: CANANDAIGUA

ORG_NAME: VETERANS AFFAIRS, UNITED STATES DEPARTMENT OF

PHR: We will refine a cognitive-behavioral therapy for loneliness and substance use disorder (CBT-L/SUD) then assess its feasibility and acceptability first through a small single-arm trial, then a small randomized clinical trial. Data from these trials will provide data to inform treatment satisfaction, and feasibility of study procedures, outcome measurement, and treatment delivery. Findings will be used to inform a larger, fully-powered Merit Award application testing the effects of CBT-L/SUD.

PI_NAMEs: ASHRAFIOUN, LISHAM  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;AODR mortality;arm;Award;Behavior;Behavioral;Behavioral Model;behavioral response;Belief;Caring;Cessation of life;Chronic Disease;Clinical;Cognitive;cognitive testing;Cognitive Therapy;Coping Skills;COVID-19;craving;Data;design;Development;Diagnostic Factor;Dissemination and Implementation;effective intervention;Emotional;Evidence based intervention;Feasibility Studies;Feedback;Health Personnel;Health Services Accessibility;High Prevalence;high risk;Household;improved;Individual;innovation;Intervention;intervention delivery;Knowledge;Life Expectancy;Loneliness;Manuals;Marriage;Measurement;Measures;Mental Health;Mental Health Services;Meta-Analysis;Methodology;Morbidity - disease rate;mortality;neglect;new therapeutic target;Outcome;Outcome Assessment;Outcome Measure;Overdose;Pain;pain reduction;Participant;Persons;Pharmaceutical Preparations;physical conditioning;Pilot Projects;Population;Primary Care;Procedures;programs;provider factors;psychosocial;Psychosocial Factor;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recovery;recruit;reduced substance use;Rehabilitation therapy;Relapse;relapse risk;Reporting;Research;Research Support;Risk;Risk Factors;Risk Reduction;Rural;satisfaction;Sleep disturbances;Social Distance;social engagement;Social Functioning;Social Interaction;Social isolation;Social Network;Social Perception;social situation;social stigma;social stressor;Social support;substance use;Substance Use Disorder;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Technology;telehealth;Testing;Therapeutic Intervention;Translating;treatment program;trend;Veterans;Work

PROJECT_TITLE: Addressing loneliness and substance use with telehealth CBT

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Neurological injuries and diseases negatively affect quality of life for millions of people in the US, such as the various visual and oculomotor pathologies (e.g. optic ataxia and oculomotor apraxia) caused by damage to the posterior parietal cortex (PPC). Despite extensive research, much remains unknown about how PPC encodes motor decisions, in part due to technical limitations of existing neural recording technologies. This project aims to increases our understanding of the neuronal circuits involved in these visual-motor pathologies by using a novel neuroimaging technique (functional ultrasound neuroimaging) and conventional electrophysiology to investigate how and where motor and decision variables are represented from the single neuron level to detailed maps of neural populations across the entire PPC.

PI_NAMEs: GRIGGS, WHITNEY SCOTT (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Affect;Anatomy;Animals;Anterior;Apraxia;Area;Ataxia;Bilateral;Brain region;cerebral hemodynamics;clinical application;Complex;cortex mapping;Cues;Data;Doctor of Philosophy;Electrophysiology (science);environmental change;Exhibits;Eye;Fingers;Functional disorder;Functional Magnetic Resonance Imaging;Future;Hand;hemodynamics;Human;Image;in vivo;innovation;Knowledge;lateral intraparietal area;Lesion;Link;Liquid substance;Location;Macaca mulatta;Maps;Measures;Mentorship;meter;Methods;Motor;motor disorder;Movement;multisensory;Music;Nervous System Disorder;Nervous System Trauma;neural;neuroimaging;neuronal circuitry;Neurons;neurovascular coupling;nonhuman primate;novel;oculomotor;Optics;Parietal;Parietal Lobe;Pathology;Patients;Pattern;Persons;Physicians;Play;Population;Probability;Quality of life;Reporting;Research;Resolution;response;Rewards;Role;Saccades;Scientist;Signal Transduction;skills;spatiotemporal;Specific qualifier value;Techniques;Technology;temporal measurement;Testing;ultrasound;Validation;ventral intraparietal area;Visual;visual motor;Visual Motor Coordinations

PROJECT_TITLE: Uncovering the Internal Representation of Actions in Posterior Parietal Cortex


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Cancer;Cardiovascular;Heart Disease;Machine Learning and Artificial Intelligence;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN DIEGO

ORG_NAME: VALA SCIENCES, INC.

PHR: FDA guidelines stipulate that all new drugs be tested for dangerous side-effects on the heart as part of preclinical research; however, the current tests are poorly predictive of both dangerous and safe drugs leading to unwarranted attrition and dangerous drugs reaching clinic. Human cardiomyocytes derived from donor tissue (iPSC-derived cardiomyocytes) are widely considered to hold great promise for clinical trial in a dish studies of drug cardiotoxicity. This STTR proposal is to commercialize a high throughput platform to accurately identify drug candidates that have cardiac side effects, in particular adding the ability to detect the type of primary heart cell damage common with anti-cancer drugs in a fully automated (high throughput) robotic assay for the first time, to improve the efficiency of preclinical research and the safety of human clinical trials, which will also likely have the added benefit of reducing animal research.

PI_NAMEs: PRICE, JEFFREY H. (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Action Potentials;Address;Animal Experimentation;Animal Model;Animal Testing;Animals;Antineoplastic Agents;Arrhythmia;Artificial Intelligence;Biological Assay;Calcium;calcium indicator;cancer recurrence;cancer survival;Cancer Survivor;cancer therapy;cancer type;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiotoxicity;cell injury;Cells;cellular imaging;chemotherapy;Clinic;Clinical;clinical trial in a dish;Clinical Trials;commercialization;Complex;Contractile Proteins;cytotoxicity;Dangerousness;detection assay;dosage;Dose;drug candidate;drug discovery;Drug Industry;Guidelines;Heart;heart cell;Heart Diseases;Human;human induced pluripotent stem cells;Image Cytometry;Impairment;improved;In Vitro;induced pluripotent stem cell derived cardiomyocytes;Kinetics;Label;Malignant Neoplasms;Marketing;Measures;Methods;Microscopy;Mitochondria;Motion;novel therapeutics;Pathologic;Pharmaceutical Preparations;Phase;pre-clinical;Pre-Clinical Model;pre-clinical research;Protocols documentation;Research Contracts;response;Robotics;Safety;Sensitivity and Specificity;side effect;Small Business Technology Transfer Research;Speed;Testing;Therapeutic;therapeutic candidate;Time;Tissue Donors;Treatment Side Effects;validation studies;voltage

PROJECT_TITLE: Combined Cardiomyopathy, e.g., of Cancer Chemotherapeutics, and Proarrhythmia for Cardiotoxicity Clinical Trials-in-a-Dish (CTiD) with iPSC-Derived Cardiomyocytes


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Caregiving Research;Clinical Research;Disability Research;Networking and Information Technology R&D (NITRD);Prevention;Rehabilitation;Wound Healing and Care

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PI_NAMEs: POLLARD, NANCY S (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Algorithms;Area;Attention;Awareness;Bathing;Caregiver Burden;caregiver education;Caregivers;Cessation of life;Collection;Communities;Data Set;Databases;decubitus ulcer;Democracy;design;Development;disability;Disabled Persons;Education;empowerment;Engineering;Fostering;Geometry;Goals;Hand;haptics;Health;health care settings;Health Professional;Healthcare;Healthcare Systems;Home;Hospital Costs;Human;Human body;human-robot interaction;improved;Incidence;Individual;Injury;injury prevention;innovation;insight;Instruction;Maintenance;Measures;Methods;Modification;Motor;Movement;multimodality;novel;Occupational Therapy;open source;Outcome;Pain;pain reduction;Patient Care;patient privacy;Persons;physical impairment;practical application;preference;pressure;Prevalence;prevent;Privacy;Process;programs;Psychology;Quality of life;Research;Robot;robot rehabilitation;robotic system;Robotics;skills;Skin;Skin Care;Time;Touch sensation;Training;Translating;United States;Visualization;Work;Workload

PROJECT_TITLE: SCH: Human-Robot Contact for Bathing and Skin-Care Assistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-N (50)]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Disability Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PI_NAMEs: TIAN, YAPENG ;ZHAO, YUHANG  (contact)

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: Activities of Daily Living;Adopted;Adoption;Affect;Area;Artificial Intelligence enhanced;artificial intelligence model;Augmented Reality;Awareness;Benchmarking;Blindness;Complex;cooking;Crowding;data modeling;Data Set;design;Development;Dimensions;Ego;Elements;empowerment;Environment;Evaluation;Exposure to;Feedback;field study;Glass;Health;Human;image processing;improved;Instruction;interest;Interview;Ions;Mission;Modeling;Motion;multimodal data;novel;object perception;object recognition;Output;Participant;Persons;Preparation;Process;Public Health;Quality of life;Rehabilitation therapy;Research;Safety;Semantics;Side;Social Well-Being;System;Techniques;Technology;Time;Vision;vision aid;vision rehabilitation;Vision research;Visual;Visual Fields;Visual impairment;visual map;Visual Perception

PROJECT_TITLE: SCH: Scene-Aware AR Systems for Low Vision People in Activities of Daily Living


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative There is no treatment to correct the reduced brain blood flow observed in Alzheimer disease patients, although this reduction likely contributes to cognitive deficits and may accelerate disease progression. We recently found that blood flow in individual brain capillaries is stalled by arrested white blood cells in mouse models of Alzheimer’s disease, and we now propose to investigate the molecular and cellular mechanisms causing these capillary stalls and to determine the impact of increasing brain blood flow by interfering with capillary stalling on the progression of disease. These capillary stalls are a potential mechanism for the decreased blood flow in AD, and this work could lead to novel therapies that improve cognitive function and slow Alzheimer’s disease progression.

PI_NAMEs: NISHIMURA, NOZOMI ;SCHAFFER, CHRIS B (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: 15 year old;abeta accumulation;Acceleration;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Antibodies;Basement membrane;Binding;Blood capillaries;Blood Cells;Blood flow;Cell Adhesion Molecules;cerebral capillary;Cerebrovascular Circulation;Cognitive deficits;cognitive function;constriction;Disease Progression;Endothelial Cells;Endothelium;experimental study;Exposure to;Fluorescence Microscopy;Funding;Grant;Hippocampus;Hour;hypoperfusion;Image;improved;Incidence;Individual;Knock-in Mouse;Lasers;Leukocytes;Manuscripts;Membrane Proteins;Molecular;mouse model;Mus;neuropathology;neutrophil;novel;novel therapeutics;Oxidases;Peptide Initiation Factors;Performance;Pericytes;Photons;Publications;Reactive Oxygen Species;Role;Short-Term Memory;spatial memory;Surface;System;Testing;Time;two-photon;Work

PROJECT_TITLE: Stalled capillary flow: a novel mechanism for hypoperfusion in Alzheimer disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Impaired artery function is a major risk factor for cardiovascular diseases in men and women who have undergone cancer treatment with Doxorubicin chemotherapy. In the proposed project, I will investigate the role of cellular senescence in regulating arterial dysfunction with Doxorubicin in preclinical mouse models and in humans by conducting a trial in Doxorubicin-treated cancer patients. Overall, the findings of this project have the potential to identify cellular senescence as a new therapeutic target for preventing/treating impaired artery function with Doxorubicin and thereby reducing risk of cardiovascular diseases.

PI_NAMEs: CLAYTON, ZACHARY S. (contact)

PROJECT_TERMS: Acceleration;Address;Advanced Glycosylation End Products;Advisory Committees;Age;Antioxidants;Aorta;Arteries;Atherosclerosis;Atomic Force Microscopy;Award;Biological Availability;Blood Vessels;brachial artery;Cancer Patient;Cancer Survivor;cancer therapy;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Pathology;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;career development;Carotid Arteries;Cell Aging;Cell Culture Techniques;Cell Cycle Arrest;Cells;Cessation of life;chemotherapeutic agent;chemotherapy;Circulation;Clinical;Collagen;crosslink;Data;Deposition;Doxorubicin;Elasticity;Elastin;Endothelial Cells;Endothelium;Event;experimental study;Extramural Activities;Faculty;Female;Femur;follow-up;Functional disorder;Funding;Future;Genes;Genetic;heart function;Human;Impairment;improved;in vivo;Inflammation;Inflammatory;Infusion procedures;innovation;insight;Institution;International;Intervention;Laboratories;Learning;male;Measures;Mediating;member;men;Mentors;Mitochondria;Morbidity - disease rate;mortality;mouse model;Mus;National Heart, Lung, and Blood Institute;new therapeutic target;Nitric Oxide;Nitric Oxide Synthetase Inhibitor;novel;Oncology;Oxidative Stress;pharmacologic;Phenotype;Physiologic pulse;Plasma;Plasma Exchange;Positioning Attribute;Postdoctoral Fellow;pre-clinical;preservation;prevent;Process;Production;Reactive Oxygen Species;Recording of previous events;Research;Research Personnel;Research Priority;response;Risk Reduction;Role;Scientist;seal;senescence associated secretory phenotype;senescent cell;sex;skills;small hairpin RNA;Smooth Muscle Myocytes;Source;Structural Protein;Technical Expertise;tenure track;Training;Translating;translational study;United States National Institutes of Health;Vascular Endothelial Cell;Vascular Endothelium;Vascular Smooth Muscle;Woman;young adult

PROJECT_TITLE: Translational studies of cellular senescence as a regulator of doxorubicin-mediated arterial dysfunction

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Genetics;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The work conducted under this proposal will provide further insight into the regulative role of senescent cells within microenvironments in vivo. Leveraging the tools already developed and acquiring new state of the art techniques, we will identify the SASP factors of p16INK4a+ lung fibroblasts at homeostasis and during acute alveolar injury. The knowledge gained through this study will provide clarity on the role SASP from p16INK4a+ plays in regulating epithelial alveolar regeneration.

PI_NAMEs: REYES DE BARBOZA, NABORA SOLEDAD (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 3-Dimensional;Acute;Address;Adult;Age;Aging;airway epithelium;airway regeneration;Alleles;Alveolar;alveolar epithelium;Alveolus;Anatomy;Architecture;Basement membrane;Behavior;Bioinformatics;biological adaptation to stress;Biological Assay;Biology;Biotinylation;career development;CDKN2A gene;Cell Aging;Cell Cycle;cell growth;Cell Size;cell type;Cells;Characteristics;Coculture Techniques;Cyclin-Dependent Kinase Inhibitor 2A;Cyclins;cytokine;Dasatinib;Data;Dependence;Development;DNA Damage;environmental stressor;epithelial injury;epithelial stem cell;Epithelium;epithelium regeneration;Excision;experimental study;Fibroblasts;Foundations;Gases;Gene Expression Profile;Genetic;Genetic Transcription;Goals;Growth;Growth Factor;Homeostasis;IL6 gene;Immune;immune cell infiltrate;Immune system;in vivo;Inflammatory;inhibitor;injured airway;Injury;injury and repair;insight;knock-down;Knowledge;Lead;Ligands;Lung;lung regeneration;Matrix Metalloproteinases;Mediating;Metabolic;Modeling;Mus;Names;Natural regeneration;Nature;novel;Oncogenic;Organoids;Phase;Play;Polyploidy;Population;programs;Proliferating;Protein Secretion;Proteomics;Protocols documentation;Pulmonary alveolar structure;Quercetin;receptor;repaired;Reporter;Resistance;response;response to injury;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;single-cell RNA sequencing;skills;stem cell growth;stem cell proliferation;stem cells;Stimulus;Stress;stressor;Surface;Techniques;Testing;tissue repair;Tissues;tool;TP53 gene;Training;transcriptome;transcriptome sequencing;transcriptomics;Tumor Escape;Tumor Suppressor Proteins;tumorigenesis;Up-Regulation;Work;wound healing;young adult

PROJECT_TITLE: p16INK4a+ fibroblasts regulate epithelial regeneration after injury in lung alveoli through the SASP


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Prevention;Serious Mental Illness

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative Nearly half of patients do not recover following the first line of treatment for OCD, exposure and response prevention (ERP). This study proposes to test a novel method of augmenting ERP, a computerized, scalable intervention targeting interpretation bias, which is a critical mechanism underlying OCD. The overall goal is to contribute to the development of technology-driven augmentations to ERP to enhance response rates, which may generalize to treatment for other OC-related and anxiety disorders in the future.

PI_NAMEs: FALKENSTEIN, MARTHA J (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Adherence;analog;Anxiety Disorders;Area;Behavioral;career development;Characteristics;Clinical;Clinical Treatment;Cognitive;computerized;Development;Disease;Ecological momentary assessment;effectiveness trial;Exposure to;feasibility testing;Future;Goals;improved;Individual;innovation;Intervention;Investigational Therapies;Machine Learning;Maintenance;Maps;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Modeling;Modification;multimodality;novel;Obsessive-Compulsive Disorder;Outcome;patient oriented research;Patients;personalized predictions;Population;Prevention;Probability;programs;reduce symptoms;Refractory;Relapse;Research Personnel;response;Sampling;skills;Stimulus;Symptoms;Techniques;Technology;technology development;Testing;Training;treatment response

PROJECT_TITLE: Interpretation Bias as a Mechanism of Treatment Response in OCD


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine;Prevention

ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: RELEVANCE (See instructions):  The proposed project utilizes multiple data sources and collects different data modalities to develop  biomarkers and personal wearable sensors to monitor the treatment effectiveness and progression of  Parkinson's diseases, which directly align with the mission of NLM. The proposed computational methods  can be generally applied by biological researchers to study disease specific metabolisms and variations  and can be extended to study other species or biological systems. The proposed wearable sensor

PI_NAMEs: WU, WENZHUO ;ZAUBER, S ELIZABETH;ZHANG, CHI  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Anions;Biological;Biological Markers;biological systems;biomarker discovery;biomarker panel;biomarker selection;Body Fluids;Cells;Clinical;clinical application;Computer Models;Computing Methodologies;Data;data modalities;design;Detection;Diagnosis;Disease;Disease Management;Disease Progression;Early Diagnosis;empowerment;Goals;Infrastructure;innovation;Instruction;Ions;Knowledge;machine learning prediction;Measures;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Mission;Monitor;multimodality;Multiomic Data;multiple data sources;Nanotechnology;Neurodegenerative Disorders;non-invasive monitor;novel;Organ;Parkinson Disease;Patients;Peptides;Performance;performance tests;Pharmacotherapy;Phenotype;Physics;Preclinical Testing;predictive marker;Process;Property;Protocols documentation;Research;research clinical testing;Research Personnel;response;Sensitivity and Specificity;sensor;sensor technology;specific biomarkers;Specificity;Stimulus;Structure;System;treatment effect;Treatment Effectiveness;United States;United States National Library of Medicine;Variant;wearable device;wearable sensor technology

PROJECT_TITLE: SCH: AI-empowered wearable multimodal sensors (AI-MEDALLION) for noninvasive monitoring


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Amyloid-bodies and the Evolution of Malignancies Narrative Cancer cells encounter various adverse environmental conditions during tumorigenesis. Our group has recently discovered that cancer cells solidify their proteins to enter spore-like state, like how yeast undergo sporulation. By this process of protein solidification, cancer cells can resist the harsh conditions of the tumor microenvironment.

PI_NAMEs: LEE, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Amyloid;amyloid formation;amyloidogenesis;Animal Model;Balbiani Body;Biochemical;Biogenesis;Biological;Biological Assay;biophysical properties;cancer cell;Cell Cycle Regulation;Cells;Clinical;Dedications;Depressed mood;Detection;DNA biosynthesis;Elements;Evolution;fascinate;Germ Cells;Goals;granule cell;Growth;Human;Human Genome;Immobilization;in vivo;Junk DNA;Knowledge;Liquid substance;Malignant - descriptor;Malignant Neoplasms;Mediating;Metabolic;metabolic depression;Metabolism;Modeling;Nature;neoplastic cell;Normal tissue morphology;Nuclear Envelope;Nucleic Acids;nucleotidyltransferase;Oncogenic;Participant;Pathway interactions;Phase Transition;Phenotype;Physiological;Play;Process;programs;Proliferating;Proteins;Proteome;Proteomics;Publishing;recruit;Reporting;Reproduction spores;response;Ribosomes;RNA;Role;Sampling;Signal Transduction;Solid;solid state;Stimulus;Stress;stress granule;stressor;Tail;Testing;tumor;tumor microenvironment;tumorigenesis;tumorigenic;Untranslated RNA;Work;Xenopus;Yeasts

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Chronic Obstructive Pulmonary Disease;Clinical Research;Complementary and Integrative Health;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: RELEVANCE (See instructions):  For many chronic pathologies, it is difficult to determine if symptoms are the result of an acute bout of  disease worsening or `usual' variation in disease severity. This project will create and validate a passive  wearable electronic system and analytic approach that can provide diagnostic information regarding  whole person health. Providing timely and effective interventions will lead to increased quality of life as  well as lower healthcare costs.

PI_NAMEs: MARKVICKA, ERIC  (contact)

PROGRAM_OFFICER_NAME: HORGUSLUOGLU, EMRIN U

PROJECT_TERMS: Acute;Artificial Intelligence;Asthma;Biochemical;Biological Monitoring;Bioperiodicity;Blood;Cause of Death;Chemicals;Chronic;chronic inflammatory disease;Chronic Obstructive Pulmonary Disease;Clinical;clinical diagnostics;Clinical Research;Collection;Communication;Coupling;Data;Data Analytics;Data Collection;data streams;design;Detection;Devices;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Procedure;Diagnostic Specificity;digital;Disease;disease diagnosis;Drug Prescriptions;Early Diagnosis;effective intervention;electronic nose;Electronics;Engineering;Event;Excretory function;flexibility;Frequencies;Goals;Health;Health Care Costs;Health Status;Healthcare;Heart Diseases;Hour;Human;Human body;improved;Individual;Inflammatory;innovation;Instruction;Interdisciplinary Study;Intervention;intervention effect;Location;Machine Learning;manufacturing process;Mathematics;Measures;Medical;Modality;Modeling;Monitor;Morbidity - disease rate;mortality;Movement;multi-component intervention;multidimensional data;multidisciplinary;multimodality;non-invasive monitor;Nose;novel;Outcome;overtreatment;Pathology;Patient Outcomes Assessments;Patients;Persons;Pharmaceutical Preparations;Physicians;Physiological;Positioning Attribute;Process Measure;Property;Quality of life;Questionnaires;remote monitoring;Reporting;Reproducibility;Research;risk stratification;Scientist;sensor;Severity of illness;Shapes;signal processing;social;Standardization;Structure;success;Symptoms;System;Testing;Therapeutic Intervention;Time;tool;Urine;Validation;Variant;wearable device;wearable sensor technology;whole health

PROJECT_TITLE: SCH: A multimodal wearable device to measure physiologic coupling


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: CORIDEA, LLC

PHR: Public Health Relevance Obstructive hypertrophic cardiomyopathy is a common cardiac disorder that in some people can lead to substantial limitations in acts of daily living, poor prognosis, and mortality. Gold standard therapy for patients who do not respond to medical management are invasive septal reduction surgeries that have a high rate of serious side-effects and mortality. This proposal will validate a new minimally invasive method to precisely treat the source of the obstruction in a procedure that we believe will be safer and better suited for many patients than the currently available treatments.

PI_NAMEs: LEVIN, HOWARD  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Ablation;Acceleration;Acoustics;Acute;Adverse effects;Alcohols;Anatomy;animal data;Animal Model;Animals;atrioventricular node;behavior observation;Brain;Cardiac conduction system;Cardiac Electrophysiologic Techniques;cardiac magnetic resonance imaging;Catheters;Certification;Characteristics;Chest Pain;Chronic;Clinical;Clinical Pathology;Clinical Trials;commercialization;comorbidity;Coronary artery;Critical Illness;Dangerousness;Data;Defibrillators;design;design verification;Development;Devices;Disease;dosimetry;Dyspnea;Elements;Endothelium;Equilibrium;Equipment;Femur;Frequencies;Future;Gel;Geometry;Grant;healing;Health;Heart Block;Heart Diseases;heart rhythm;Histopathology;Human;Hypertrophic Cardiomyopathy;Hypertrophy;implantation;improved;Industry Standard;Inflammation;Inherited;Injury;International;Irrigation;Laboratories;Left;Lesion;Life;Lung;manufacturability;manufacture;Medical;meetings;Methods;minimally invasive;Modality;mortality;Nature;novel;Obstruction;Operative Surgical Procedures;Organ;Output;Pacemakers;Pathology;patient subsets;Patients;Performance;Persons;Phase;Physics;pre-clinical;Pre-Clinical Model;Preparation;preservation;Procedures;Process;Prognosis;prototype;public health relevance;Radiation;Refractory;Reporting;research clinical testing;Resistance;Resolution;response;Right ventricular structure;Risk;Risk Reduction;Safety;side effect;Small Business Innovation Research Grant;Source;Sterility;System;Techniques;Technology;Testing;Therapeutic;Thick;Thinness;Thrombus;Tissues;tool;Transducers;Ultrasonic Transducer;ultrasound;ultrasound ablation;Venous;Ventricular;Ventricular septum;verification and validation;Work

PROJECT_TITLE: Minimally Invasive High Intensity Therapeutic Ultrasound for the Treatment of Obstructive Hypertrophic Cardiomyopathy


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Rehabilitation;Stroke

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Aphasia (acquired language impairment) is one of the most common consequences of stroke and often leads to significant long-term disability. Audiovisual recordings of individuals with aphasia can provide rich information and are valuable for research and clinical education, yet the sharing of identifiable audiovisual data raises ethical concerns regarding privacy, confidentiality, and consent. This study will explore the attitudes of individuals with aphasia and their care partners towards sharing identifiable audiovisual data.

PI_NAMEs: DE RIESTHAL, MICHAEL R (contact);WILSON, STEPHEN M

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Acoustics;acute stroke;Address;Administrative Supplement;Aphasia;aphasia recovery;Assessment tool;Attitude;audiovisual speech;Bioethics;Brain Injuries;Caring;Clinical;clinical care;Comprehension;Consent;Consent Forms;Data;Data Analyses;Data Set;data sharing;Development;Diagnosis;Education;Elements;Ensure;Equilibrium;Ethics;Evaluation;evidence base;experience;Face;follow-up;Future;Goals;Health protection;Impairment;Individual;Informed Consent;insight;Interview;Knowledge;Language;Language Development;language impairment;language outcome;lexical retrieval;Life;Long term disability;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;multimodality;Natural Language Processing;Nature;neural correlate;neuroimaging;Neuronal Plasticity;novel;parent project;Participant;patient privacy;Patients;Pattern;Persons;phonology;Policies;Policy Maker;Population;post stroke;Privacy;Procedures;Process;Prognosis;Publishing;Recommendation;Recovery;recruit;Rehabilitation therapy;Research;Research Personnel;Sampling;Speech;stakeholder perspectives;Stroke;stroke patient;Structure;Students;Time;Voice;Vulnerable Populations

PROJECT_TITLE: Neural Correlates of Recovery from Aphasia After Stroke

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Women's Health Research

ORG_CITY: Boston

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: RELEVANCE (See instructions): The proposed project will develop and test an easy-to-use multi-modal monitoring system of sensors and data processing algorithms intended for use by older adults to reveal subtle changes in cognition and mobility, both early indicators of pending Alzheimer's disease and related dementia. This will provide important insight into an early window for interventions to delay or prevent the onset of these devastating health outcomes. The results of this project will thus support the National Institute on Aging's Strategic

PI_NAMEs: SONKUSALE, SAMEER R (contact)

PROGRAM_OFFICER_NAME: PLUDE, DANA JEFFREY

PROJECT_TERMS: Address;Age;age group;age related;aging population;Algorithms;Alzheimer's disease related dementia;Alzheimer's disease risk;analytical method;bioelectronics;Biophysics;Biosensing Techniques;Biosensor;Clinical;Cognition;Cognitive;cognitive function;cognitive performance;computerized data processing;cost effective;Coupled;Data;Data Analyses;Data Analytics;Data Correlations;data streams;Dementia;demographics;density;design;Deterioration;Development;Devices;Diet;direct application;Early Diagnosis;Electrodes;Electrolytes;Emerging Technologies;Engineering;Environment;Feasibility Studies;Fiber;flexibility;Formulation;Gait;Gel;Genetic;Head;Health;Health Care Costs;healthy aging;heart rate variability;human old age (65+);human study;Impaired cognition;Individual;innovation;insight;Instruction;Intervention;Ions;Laboratories;Learning;Life;Location;machine learning algorithm;machine learning model;materials science;Measurement;Measures;men;Methods;Modeling;Monitor;Motion;Motor;Movement;multimodal data;multimodality;National Institute on Aging;new technology;novel;nutrition;older adult;older men;older women;Outcome;Performance;Periodicals;Persons;Physical activity;Physical Function;Physical Performance;Population;Posture;Predictive Analytics;pressure sensor;prevent;Prevention;Process;Property;Public Health Informatics;real time monitoring;Research;Respiration;Risk;Role;sensor;Sensory Manifestations;Series;signal processing;smart watch;software systems;Solvents;statistical and machine learning;Statistical Models;Structure;System;Techniques;Testing;Time;Time Series Analysis;Traction;Validation;wearable device;wearable sensor technology;wireless data transmission;Woman;Work

PROJECT_TITLE: SCH: Multi-modal Biosensing and Predictive Analytics for Continuous Monitoring of Mobility and Cognition in an Aging Population


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Genetics;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE This supplemental proposal provides a timely response to an environmental accident and chemical exposure in East Palestine, Ohio by initiating community engagement participatory research, providing context with qualitative research approaches, and establishing a baseline biospecimen repository within the scope of the parent grant. Specifically, the supplement will add children to the registry of participants in the parent grant, collecting the same novel biomarkers and health information as the parent grant, including measures of behavioral functioning specific to children. The utility of novel biomarkers for chemical-wide exposures establishes a new paradigm for environmental exposure assessment and health changes. The community engagement establishes a cornerstone for continued and future research determining long-term health impacts, as well as establishing a two-way relationship between community members and health researchers.

PI_NAMEs: SCHUMACHER, FREDRICK RAY (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: absorption;Academy;Accidents;Acrolein;Acrylates;Acute;Address;Adult;Advocate;Age;Air;air sampling;Anxiety;Area;Atmosphere;Behavior assessment;behavior measurement;behavioral outcome;behavioral response;Benzene;Biological Markers;Biological Specimen Banks;Blood;Carcinogens;Categories;Cessation of life;Chemical Exposure;Chemicals;Child;Chronic;cohort;Communities;community advisory board;community engaged research;community engagement;Community Outreach;community research;Cross-Sectional Studies;Data;Development;Disasters;Disease Surveillance;disorder risk;DNA;Drug or chemical Tissue Distribution;Educational workshop;Emotional;emotional symptom;environmental chemical exposure;Environmental Exposure;Environmental Health;Environmental Impact;Environmental Pollution;Epidemiologist;Epigenetic Process;Event;Exanthema;experience;Explosion;Exposure to;Eye;Family;Family Study;Fishes;Foundations;Future;Gases;genomic biomarker;genotoxicity;Geography;hazard;Hazardous Chemicals;Health;Health Hazards;Healthcare;Heavy Industries;Hour;Human;Hydrogen Chloride;Immunologics;Individual;Infrastructure;innovation;Institution;Irritants;Link;Location;Longitudinal Studies;Measures;member;Mental Depression;Mental Health;Monitor;n-butoxyethanol;National Institute of Environmental Health Sciences;Nature;Neurologic;novel;novel marker;Ohio;parent grant;Parental Consent;Parents;Participant;Pathway interactions;Phosgene;physical conditioning;physical symptom;Poison;pollutant;prevent;Proxy;Public Health;Qualitative Research;Radial;Reaction Time;recruit;Registries;Reporting;reproductive;Research;Research Personnel;Research Proposals;research study;residence;respiratory;response;Risk;Running;sex;Site;skin irritation;Social Impacts;Somatic Mutation;Special needs plan;Stream;Surface;Surveys;Symptoms;teacher;Testing;Time;Toxicant exposure;Toxin;Training;transcriptomics;Urine;Variant;Vinyl Chloride;Voice;Vulnerable Populations;Water

PROJECT_TITLE: Supplement Admin - Healthy Futures Research Study: Linking Somatic Mutation Rate with Baseline Exposure in East Palestine


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Stroke

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PI_NAMEs: SU, HAO  (contact)

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TERMS: Address;Adoption;Anatomy;Aneurysm;Archives;Arteries;Awareness;Behavior;Blood coagulation;Blood flow;Blood Vessels;Brain;Brain hemorrhage;Capital;care outcomes;Catheters;Cerebrovascular Circulation;Chronic disability;Clinical;clinical practice;Coagulation Process;comparison intervention;Complex;computer science;Decision Making;design;differential geometry;Discipline;Doctor of Medicine;Effectiveness;effectiveness evaluation;Engineering;Equipment;experience;Freedom;Future;Goals;haptic feedback;haptics;Human;human-robot interaction;improved;Instruction;instrument;Intervention;Ischemic Stroke;Jaw;Learning;Machine Learning;Manuals;Mechanics;Medical;Medicine;meter;Methods;minimally invasive;Modeling;mortality;neurovascular;novel;operation;Operative Surgical Procedures;Outcome;Patients;Physics;Procedures;prototype;Radiation;Radiation exposure;Reaction Time;Risk;risk minimization;Robot;robot assistance;robotic system;Robotics;Rod;Roentgen Rays;Rupture;Ruptured Aneurysm;Safety;Science;Side;simulation;simulation environment;skills;Stroke;stroke therapy;Structure;Surgical Instruments;System;Tactile;teleoperation;Therapeutic Embolization;Thrombectomy;Time;tool;Training;usability;virtual;Work

PROJECT_TITLE: SCH: Versatile and Compact Telerobot with Haptic Feedback and Physics-Informed Simulation for Safety Enhanced Neurovascular Interventions


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE STATEMENT  Ascending thoracic aortic aneurysm (ATAA) is a major cardiovascular health problem characterized by a dilated aorta that may eventually dissect or rupture (fail). An accurate assessment of ATAA failure risk is a major clinical need. This project will use experimental biomechanics, computer modeling, and real and virtual patient imaging data to better assess ATAA failure risk.

PI_NAMEs: BAROCAS, VICTOR H;WAGENSEIL, JESSICA  (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Aneurysm;Animal Model;Aorta;biobank;Biological Markers;biomarker identification;Biomechanics;cardiovascular health;career development;Categories;Clinical;Computer Models;Computer Systems;Dangerousness;Data;Diameter;Dissection;Equilibrium;experience;Failure;falls;Funding;Generations;Genetic;Geometry;Growth;Guidelines;hemodynamics;Human;human data;Image;Literature;Machine Learning;Marfan Syndrome;mechanical properties;Modeling;mouse model;Mus;novel;Operative Surgical Procedures;Outcome;parent grant;Patient imaging;Patient-Focused Outcomes;Patients;Physics;public health relevance;Publishing;repaired;Research;Research Project Grants;Research Training;Risk;Rupture;Sampling;Scanning;Shapes;Speed;Structure;surgical risk;Testing;Thoracic Aortic Aneurysm;Time;Tissues;tool;Training;Translating;virtual human;virtual patient

PROJECT_TITLE: Complementary animal and computational models for biomarker identification in ascending thoracic aortic aneurysm

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: AMHERST

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative Membrane Associated RING CH (MARCH) family of proteins were recently found to restrict HIV-1 replication by blocking envelope incorporation in the budding virions in the producer cells. Nevertheless, many questions remain regarding the role of this family of proteins during HIV-1 infection. A better understanding of the antiretroviral mechanism of MARCH proteins and its effect on HIV-1 infection has the potential to be utilized for the development of new therapeutic strategies.

PI_NAMEs: STAVROU, SPYRIDON  (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Anti-Retroviral Agents;Antigen Presentation;Cell Surface Receptors;Cells;Cellular Membrane;Clinical;Development;Excision;Genome;Histocompatibility Antigens Class II;HIV;HIV-1;Homologous Gene;Human Herpesvirus 8;Immune response;Infection;Mediating;member;Membrane;novel therapeutic intervention;Predisposition;Protein Family;Proteins;receptor;Regulation;Reporting;Research;Resistance;Retroviridae;Role;Therapeutic;Time;Ubiquitin family;ubiquitin ligase;ubiquitin-protein ligase;Viral;Viral Proteins;Virion

PROJECT_TITLE: MARCH Proteins, Members of a Host Protein Family that Targets HIV


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

PHR: PROJECT NARRATIVE The ColoCare Study is a cohort of recently diagnosed patients with colorectal cancer (stage I-IV) that utilizes standardized protocols for longitudinally collecting participant questionnaires, biospecimens, medical record data, and clinical and patient-reported outcomes. Over 3,000 demographically and geographically diverse participants have been recruited (with a median follow-up time of 2.1 years, contributing >8,000 questionnaires and >17,000 biospecimens), and ColoCare data and/or biospecimens have supported 79 projects involving 72 external investigators (19 projects led by external investigators and 49 from early stage investigators and trainees). In this renewal, we will extend follow-up through 5 years post-diagnosis; prioritize recruitment of patients from underserved/understudied populations and with early-onset colorectal cancer; continue repeat ascertainment of self-reported data (including patient-reported outcomes) and blood samples; and enhance our centralized data repository and biobank to support data sharing and research that will improve colorectal cancer treatment, survivorship, and clinical outcomes. Project Narrative Page 9

PI_NAMEs: FIGUEIREDO, JANE C.;GIGIC, BILJANA ;SHIBATA, DAVID ;SIEGEL, ERIN ;TORIOLA, ADETUNJI T;ULRICH, CORNELIA M (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Address;Behavioral;biobank;Biological Markers;Blood;Blood specimen;cancer health disparity;Cancer Prognosis;Cancer Survivorship;Cessation of life;Clinical;Clinical Data;cohort;Collection;colon cancer patients;Colorectal Cancer;colorectal cancer treatment;community advisory board;Data;Data Reporting;data repository;data sharing;data warehouse;Decision Making;design;Development;Diagnosis;Disparity;early onset colorectal cancer;Enrollment;Epidemic;epidemiologic data;Ethnic Origin;experience;Feces;follow-up;Geography;improved;indexing;Infrastructure;innovation;Institution;Intervention;Knowledge;Life Style;Malignant Neoplasms;Medical Records;men;microbiome;Molecular;neoplasm registry;Newly Diagnosed;novel;novel marker;novel therapeutics;Outcome;Paper;Participant;Patient Outcomes Assessments;Patient Participation;Patient Recruitments;Patient Self-Report;Patients;Population;Population Heterogeneity;Prognosis;prospective;Protocols documentation;Publishing;Questionnaires;Race;racial diversity;recruit;Research;Research Personnel;Resources;Risk;Sampling;Science;Standardization;stool sample;survivorship;Time;Tissue Sample;translational study;Tumor Tissue;Underserved Population;Urine;Woman

PROJECT_TITLE: Transdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare Study


NIH_SPENDING_CATS: Aging;Bioengineering;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: This research will contribute to the development of a clinical decision support tool for glaucoma that enhances diagnostic accuracy and informs timely intervention. By integrating multiple sources of clinical data and validating the approach across real-world datasets, this project aims to support scalable and broadly applicable improvements in vision care, ultimately contributing to reduced rates of undiagnosed and undertreated glaucoma.

PI_NAMEs: AL-ASWAD, LAMA A;BASTANI, OSBERT ;LEE, INSUP  (contact);SOKOLSKY, OLEG

PROJECT_TERMS: accurate diagnosis;Address;Adoption;Artificial Intelligence;clinical decision support;Complex;Data;Detection;Development;Diagnosis;Disease;Early Diagnosis;effective therapy;Ensure;Equitable healthcare;Equity;Ethics;Expert Systems;Fostering;Glaucoma;health care availability;Healthcare;Human;improved;Infrastructure;innovation;Instruction;Measurement;Methods;Modality;Modeling;Morbidity - disease rate;multimodality;multiple data sources;Patients;Performance;predictive modeling;Provider;Public Health;Research;retinal imaging;Structure;support tools;Time;Treatment outcome;Trust;Uncertainty;Vision;Visit;Visual impairment;Work

PROJECT_TITLE: SCH: Robust and Equitable Clinical Decision Support in Glaucoma Detection and Progression Prediction