NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

PI_NAMEs: SCHOENBAUM, GEOFFREY  (contact)

PROJECT_TERMS: addiction;Address;Affect;Animal Model;antagonist;Area;Association Learning;Behavior;Behavioral;Brain;cocaine use;Collaborations;comorbidity;cue reactivity;Data;Decision Making;Dependence;Dopamine;dopamine system;dopaminergic neuron;drug of abuse;Educational process of instructing;expectation;Goals;graduate school;Human;insight;Intervention;Learning;Left;Link;Mediating;medical schools;meetings;Modeling;multithreading;neural;neural circuit;Neurons;neuropsychiatric disorder;Opiate Addiction;Paper;Pharmaceutical Preparations;Positioning Attribute;Postdoctoral Fellow;predictive modeling;Process;programs;Publishing;Rattus;Research;Rodent;Role;Sensory;Signal Transduction;Substance Use Disorder;System;tenure track;Work

PROJECT_TITLE: Associative learning, decision-making, and addiction


ACTIVITY: ZIA

ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Obesity;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

PI_NAMEs: APONTE, YEKA  (contact)

PROJECT_TERMS: Action Potentials;addiction;Affect;Anorexia;Anterior;Appetitive Behavior;Attention;Attenuated;awake;Behavior;Behavioral Assay;Behavioral Paradigm;Biological Models;Body Weight decreased;Bulimia;Calcium-Binding Proteins;Cell Physiology;cell type;Collection;Diabetes Mellitus;Disease;Drug abuse;drug of abuse;Eating;Eating Disorders;Electrophysiology (science);experimental study;feeding;Feeding behaviors;Feeling;Fluorescence;Food;Genetic;Glutamates;Hunger;Hyperphagia;Hypothalamic structure;Individual;interest;Laboratories;Lateral;Learning;leptin receptor;microendoscopy;Midbrain structure;Motivation;Mus;Nature;neuronal circuitry;Neurons;Nociception;Obesity;Opiate Addiction;Opioid;optogenetics;pain behavior;Parvalbumins;Pattern;Peptides;Population;Property;Regulation;Rewards;Satiation;Stimulus;Structure of nucleus infundibularis hypothalami;Synapses;therapeutic target;Weight Gain;Work

PROJECT_TITLE: Hypothalamic neuronal circuits controlling survival behaviors


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Chronic Pain;Cocaine;Depression;Genetics;Mental Health;Mental Illness;Neurosciences;Nutrition;Obesity;Opioid Misuse and Addiction;Opioids;Pain Research;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: KOOB, GEORGE  (contact)

PROJECT_TERMS: addiction;Adrenergic Agonists;Adrenergic Antagonists;Agonist;Amygdaloid structure;Analgesics;Animals;antagonist;Anti-Anxiety Agents;anti-depressive agents;anti-fungal agents;Anti-Inflammatory Agents;Antioxidants;Anxiety;Anxiety Disorders;anxiety-like behavior;Attenuated;basal forebrain;base;Behavior;beta-2 Adrenergic Receptors;Biological Assay;Brain;Brain Diseases;Brown Fat;Buprenorphine;burden of illness;Castor Oil;Cell Nucleus;Chlordiazepoxide;Chronic;Clinical;clinical development;Clinical Trials;Cocaine;cocaine exposure;cocaine self-administration;Cocaine use disorder;CRF receptor type 1;cysteinyltyrosine;Data;Diet;diet-induced obesity;disability;Dose;Drug Addiction;Drug Targeting;Drug usage;Eating;Elements;emotion regulation;Emotional;Emotions;endogenous opioids;Fatty acid glycerol esters;Feeding behaviors;Female;Gene Deletion;Gene Expression;ghrelin;ghrelin receptor;glucose metabolism;glucose uptake;Glutamates;Goals;heat stimulus;Heroin;Heroin Dependence;Hormones;Hour;Human;Hyperalgesia;Hypothalamic structure;intraperitoneal;Intravenous;kappa opioid receptors;Ketamine;Laboratories;Ligands;Locomotion;lofexidine;male;Measures;mechanical stimulus;Mechanics;Mental Depression;Mental disorders;Metabotropic Glutamate Receptors;Methadone;MK801;Molecular;Mood Disorders;Motivation;mu opioid receptors;Mus;N-Methyl-D-Aspartate Receptors;Naloxone;Naltrexone;negative emotional state;neural circuit;neuroadaptation;Neurobiology;neuron development;Neuropeptides;Neurotransmitters;new therapeutic target;Nociception;nociceptive response;non-opioid analgesic;norbinaltorphimine;novel;Nucleus Accumbens;Obesity;Ondansetron;Opioid;Opioid agonist;Opioid Antagonist;Opioid Peptide;Opioid Receptor;opioid use;opioid withdrawal;Oral;Output;oxidation;Oxytocin;Pain;Pain Measurement;pain relief;pain sensitivity;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Physiological;Play;Positron-Emission Tomography;Pre-Clinical Model;preclinical study;Process;Property;Protocols documentation;Rattus;receptor;Receptor Activation;Recording of previous events;Research;response;Ricinoleic Acids;Role;Saline;Serotonin Receptors 5-HT-3;sex;Stimulus;Stomach;Stress;Structure of terminal stria nuclei of preoptic region;Synaptic plasticity;System;Tail Suspension;Temperature;Testing;Therapeutic;Thermogenesis;Time;transcriptome sequencing;United States Food and Drug Administration;Withdrawal

PROJECT_TITLE: Neurobiology of Addiction


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Neurosciences;Substance Misuse

PI_NAMEs: LIN, DA-TING  (contact)

PROJECT_TERMS: Acute;addiction;Animal Behavior;Animal Model;Animals;Behavior;Behavioral;Brain;Brain region;Calcium;Cocaine;Code;Color;Complex;Computer Analysis;Corpus striatum structure;Custom;Data;design;Development;Dorsal;Drug Addiction;drug relapse;Drug usage;Engineering;Event;Exploratory Behavior;fluorescence microscope;Food;Functional disorder;Generations;Goals;Grain;Hallucinogens;hippocampal pyramidal neuron;Image;imaging system;Imaging Techniques;Imaging technology;Implant;in vivo;in vivo calcium imaging;in vivo imaging;indexing;Interneurons;learned behavior;learning strategy;lens;Liquid substance;Locomotion;machine learning algorithm;Maps;Medial;Methods;Microscope;microscopic imaging;Mission;Mus;National Institute of Drug Abuse;Nature;neural;neural circuit;Neuroglia;neuroimaging;neuronal circuitry;Neurons;Nucleus Accumbens;optical imaging;optogenetics;Pathway interactions;Phencyclidine;Population;Prefrontal Cortex;Rattus;Rewards;Rodent;Science;self supervised learning;social;Strategic Planning;System;Time;tool

PROJECT_TITLE: Illuminating neural coding mechanisms using in vivo calcium imaging in freely behaving rodents


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: SHI, LEI  (contact)

PROJECT_TERMS: addiction;Adenylate Cyclase;Adverse effects;Affinity;Agonist;Allosteric Site;Amphetamines;Analgesics;analog;anti-depressive agents;beta-arrestin;Binding;Binding Sites;Biological Assay;Brain;Characteristics;Chemicals;Cocaine;conformational conversion;Cyclic AMP;Data;design;Development;Dissociation;Dopamine Receptor;dopamine transporter;dosage;drug discovery;drug market;drug of abuse;Drug Targeting;Effectiveness;extracellular;Fentanyl;fentanyl analog;Free Energy;G-Protein-Coupled Receptors;Goals;GTP-Binding Proteins;Heroin;high risk;Homologous Gene;Human;Illicit Drugs;Imipramine;In Vitro;Indoles;Infiltration;inhibitor;insight;Intoxication;Lead;Ligand Binding;Ligands;Location;Modeling;Molecular Conformation;molecular dynamics;mu opioid receptors;Nervous System;Nervous System Disorder;Neurons;Neurotransmitters;novel;Opioid;Overdose;overdose death;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Play;Production;Property;Proteins;Public Health;receptor;recruit;Reporting;Research;Research Subjects;response;Role;scaffold;Series;Serotonin;serotonin transporter;side effect;sigma-1 receptor;Signal Transduction;Signaling Protein;Site;Site-Directed Mutagenesis;small molecule;Structure-Activity Relationship;Substance Use Disorder;Synapses;synergism;synthetic cannabinoid;synthetic opioid;Therapeutic;therapeutic development;therapy development;Toxic effect

PROJECT_TITLE: Structural basis for the functions of dopamine receptors, neurotransmitter transporters, and sigma 1 receptor


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Drug Abuse (NIDA only);Neurodegenerative;Neurosciences;Stimulant Use and Misuse;Stroke;Substance Misuse

PI_NAMEs: HARVEY, BRANDON  (contact)

PROJECT_TERMS: addiction;analog;Attenuated;Biological;Bromocriptine;Calcium;Cells;Cellular biology;Cocaine;Coin;Collaborations;Diabetes Mellitus;Dopamine D2 Receptor;ecstasy;Endoplasmic Reticulum;endoplasmic reticulum stress;Enterobacteria phage P1 Cre recombinase;excitotoxicity;FDA approved;Functional disorder;Genes;Glutamates;Goals;high-throughput drug screening;Homeostasis;improved outcome;Journals;KDEL receptor;Laboratories;Liver;Methamphetamine;Modeling;Monitor;mu opioid receptors;Mus;Muscle;National Institute of Drug Abuse;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;Neurosciences;novel;Pancreas;Paper;Parkinson Disease;Pharmaceutical Preparations;prevent;Production;Property;Proteins;Publishing;Rat Transgene;Rattus;receptor expression;Reporter;Reporting;Research;response;Role;Stroke;stroke model;Substance abuse problem;Substance of Abuse;Substance Use Disorder;System;Therapeutic;Tissues;tool;Transgenic Mice;Transgenic Organisms;Work

PROJECT_TITLE: Cellular mechanisms of neuronal dysfunction in addiction and neurodegeneration


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: BRADBERRY, CHARLES  (contact)

PROJECT_TITLE: Multimodal preclinical  imaging studies of decisional determinants of drug vs non-drug choice


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Patient Safety;Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: EPSTEIN, DAVID  (contact)

PROJECT_TERMS: abuse liability;adaptive intervention;addiction;Address;Agonist;alcohol cue;Annual Reports;antiretroviral therapy;Arousal;Attention;Behavior Control;Behavioral;behavioral and social science;Boredom;Bypass;chronic pain;Collaborations;Collection;comparative;Constipation;craving;Data;Dose;drinking;drug craving;Drug usage;Effectiveness;Environment;Exposure to;Feeling;Goals;HIV;HIV risk;Human;Iatrogenesis;Illicit Drugs;Intervention;Intervention Studies;Laboratories;Laboratory Study;Leadership;Leisures;Life;Link;Measures;medical schools;Memory;mental state;Methadone;Methodology;neighborhood safety;Neighborhoods;Neurobiology;Neurosciences;novel strategies;opioid abuse;Opioid replacement therapy;opioid withdrawal;Outcome;Outcome Assessment;Outcome Measure;Participant;Patients;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Physiological;Placebos;Predictive Analytics;Prevention;Probability;Procedures;Property;Protocols documentation;Psychiatry;psychologic;psychosocial;Psychosocial Stress;Publishing;Research;Research Design;Research Personnel;respiratory;response;Risk;Risk Behaviors;Risk Factors;Running;Safety;safety testing;Science;Sedation procedure;side effect;Site;Sleep disturbances;social;Social Sciences;Stress;Substance Use Disorder;substance use treatment;Technology;Testing;Therapeutic;therapy adherence;Time;translational study;treatment research;Universities;Vendor;Virginia;wearable device;Work

PROJECT_TITLE: New approaches to addiction treatment


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse

PI_NAMEs: CURTIS, BRENDA  (contact)

PROJECT_TERMS: addiction;Address;Anxiety;Area;automated intervention;Behavior;behavior observation;Behavioral;Cellular Phone;clinical practice;Clinical Research;Communications Media;Communities;County;Cues;Data;Data Analytics;Data Collection;Data Reporting;Development;Devices;digital;Digital biomarker;digital data;Dimensions;Dropout;drug craving;Epidemic;Event;Exhibits;Feedback;Foundations;Goals;Harvest;health care availability;Health Personnel;imprint;Individual;innovation;insight;Interview;Language;Life;Linguistics;Literature;long term recovery;Machine Learning;Measurement;Measures;Methodology;Methods;Modeling;Monitor;mortality;multimodal data;multimodality;natural language;Natural Language Processing;Nature;novel;opioid overdose;Output;Participant;Patient Self-Report;Patients;Pattern;Pharmaceutical Preparations;predictive modeling;Prevention strategy;prospective;psychologic;Psychometrics;Public Health;public health research;Publications;Recovery;Relapse;relapse prediction;relapse prevention;relapse risk;Reporting;Research;Risk;Role;Self Efficacy;sensor;social media;Social support;sociodemographics;Source;Stress;substance use treatment;Surveys;System;Techniques;Testing;theories;Time;tool;Treatment outcome;treatment program;Twitter;Variant;wearable device;Work

PROJECT_TITLE: Digital Markers in Relapse and Recovery


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Drug Abuse (NIDA only);Liver Disease;Mental Health;Microbiome;Neurosciences;Nutrition;Obesity;Substance Misuse

PI_NAMEs: LEGGIO, LORENZO  (contact)

PROJECT_TERMS: acamprosate;Acylation;Acyltransferase;addiction;Addictive Behavior;Address;Adverse event;Agonist;Alcohol consumption;alcohol craving;alcohol cue;Alcohol dependence;alcohol misuse;alcohol seeking behavior;alcohol use disorder;Alcoholic Liver Diseases;Alcohols;Aldosterone;Amino Acid Substitution;Amygdaloid structure;analog;Animal Model;antagonist;Ataxia;Attention;Autopsy;bariatric surgery;base;Behavioral;behavioral pharmacology;beta diversity;biobehavior;Biological;Biological Factors;Blood alcohol level measurement;Brain;brain based;Brain imaging;brain tissue;California;Calories;Case/Control Studies;Cells;Charge;Clinical;clinical practice;Clinical Trials;Cohort Studies;comparison control;Complex;Control Groups;cue reactivity;Cues;Data;Data Analyses;Dependence;Development;Dipeptidyl Peptidases;Disease;Disulfiram;Dopamine;Dose;Double-Blind Method;double-blind placebo controlled trial;drinking;drinking behavior;Drug Kinetics;drug seeking behavior;Eating;Electronic Health Record;Electrophysiology (science);Elements;Endorphins;Environmental Risk Factor;Enzymes;Etiology;experimental study;feeding;Feeling;Female;fibroblast growth factor 21;Frequencies;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Gene Expression;genetic variant;ghrelin;ghrelin receptor;GLP-I receptor;glucagon-like peptide 1;glucose metabolism;Glutamates;gut microbiome;gut microbiota;gut-brain axis;Health;Heart;Heavy Drinking;Heterogeneity;Hippocampus;Homeostasis;Human;improved;Individual;inhibitor;innovation;Inpatients;insight;Intake;interest;Intramuscular;Investigation;Laboratories;Laboratory Study;Link;Lipids;liraglutide;Liver;male;Measures;Medicine;metabolome;Methods;microbial;Mineralocorticoid Receptor;Modality;Motor;Mus;Naltrexone;Nature;Neurobiology;Neurons;neuropsychopharmacology;Neurosecretory Systems;Neurotransmitters;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nucleus Accumbens;Obesity;Oral;Outcome;Outpatients;Pathway interactions;patient oriented;patient response;Patients;peptide hormone;Peripheral;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Phase;Phase Ib Clinical Trial;Physiological;Placebo Control;Play;pleasure;Population Study;Pre-Clinical Model;preclinical study;preference;Prefrontal Cortex;Preparation;primary care setting;Procedures;prototype;Psychiatry;Psychoneuroendocrinology;psychosocial;Randomized;Rattus;Receptor Gene;Recording of previous events;recruit;Reducing Agents;Research;Rewards;Role;Route;Safety;safety testing;Self Administration;Serotonin;Serum;Severities;Side;Signal Transduction;Speed;Spironolactone;Subcutaneous Injections;substance use;Substance Use Disorder;Surveys;System;Techniques;Testing;transmission process;United States Department of Veterans Affairs;United States Food and Drug Administration;virtual;Water consumption;Wistar Rats;Work

PROJECT_TITLE: Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

PI_NAMEs: YANG, YIHONG  (contact)

PROJECT_TERMS: Abstinence;activity marker;adverse outcome;Agonist;antagonist;Area;Auditory;Automobile Driving;Autoradiography;awake;Axon;Baclofen;Biological Assay;Brain;Brain region;Cells;cerebral blood volume;Characteristics;Corpus striatum structure;craving;Data;Data Set;Decision Making;Dendrites;design;discounting;Disease;Distant;Dopamine;dopamine D3 receptor;Dorsal;Drug Addiction;drug craving;electric field;Elements;Exhibits;experimental study;Exposure to;Fluorescence-Activated Cell Sorting;Food;Frequencies;Functional Magnetic Resonance Imaging;Gene Expression;Human;imaging modality;Impulse Control Disorders;Impulsive Behavior;Impulsivity;In Situ Hybridization;Incubated;Intervention;Link;male;Medial;Membrane Potentials;Mental disorders;Modeling;Motor;Muscimol;Nervous System Disorder;neural;neuroimaging;neuromechanism;Neurons;Neuropharmacology;neuroregulation;next generation;Nucleus Accumbens;Opiate Addiction;Opioid;Output;Oxycodone;oxycodone seeking;oxycodone self-administration;Pharmaceutical Preparations;pharmacologic;Physiologic pulse;Polymerase Chain Reaction;Positron-Emission Tomography;Pre-Clinical Model;preference;Rattus;receptor;receptor expression;Receptor Gene;Relapse;repetitive transcranial magnetic stimulation;response;Rewards;Role;Science;Self Administration;Signal Transduction;Structure;Substance Use Disorder;System;Testing;Therapeutic;Time;Training;Transcranial magnetic stimulation;Width

PROJECT_TITLE: Neuroimaging and neuromodulation of preclinical models of substance use disorders


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Precision Medicine;Prevention;Serious Mental Illness;Substance Misuse;Tobacco;Tobacco Smoke and Health

PI_NAMEs: JANES, AMY  (contact)

PROJECT_TERMS: Acceleration;addiction;Adolescent;Adoption;Adult;Alexithymias;Arousal;Awareness;Behavior;Biological;Biological Markers;biomarker development;Blood flow;Brain;brain based;Brain region;Cerebrovascular Circulation;Child;Chronic;Cigarette;cigarette smoke;Clinical;clinical predictors;clinically relevant;Cognition;cognitive control;Collaborations;Communication;comorbidity;craving;cue reactivity;Cues;Data;Data Collection;denoising;depressive symptoms;design;Development;Diagnostic;Disease;Disease remission;Drug Addiction;Economics;Electronic cigarette;elementary school;Elements;Emerging Tobacco Products;emotion dysregulation;Emotional;Evaluation;experience;Frequencies;Functional Magnetic Resonance Imaging;functional MRI scan;Goals;Health;Heart Rate;Heterogeneity;Human;Human Characteristics;Impaired cognition;improved;Individual;innovation;insight;Investigation;Judgment;Link;Literature;Major Depressive Disorder;Maps;Measures;meetings;Mental disorders;Mental Health;Modeling;Morphologic artifacts;National Institute of Drug Abuse;neural correlate;neuroadaptation;Neurobiology;neuropsychopharmacology;Neurosciences;Nicotine;Nicotine Dependence;nicotine use;Nicotinic Agonists;Nicotinic Antagonists;non-smoker;novel;Outcome;Participant;Pathway interactions;Pattern;pediatric trauma;Persons;Pharmaceutical Preparations;Phase;Policies;Population;potential biomarker;preadolescence;preventable death;Preventive;Procedures;prognostic;Property;Protocols documentation;Psychiatry;Public Health;Publishing;Qualifying;Quam;rate of change;Recommendation;Recovery;recruit;relapse risk;Reporting;Respiration;Rest;reward anticipation;Rewards;Risk;Risk Factors;Role;Scanning;School-Age Population;sex;Signal Transduction;Smoke;Smoking;smoking cessation;Smoking Cessation Intervention;Subgroup;Substance of Abuse;substance use;Substance Use Disorder;suicidal behavior;Suicide attempt;systematic review;Testing;therapy development;Time;Tobacco smoking behavior;Tobacco use;tool;Trauma;Treatment outcome;Validation;vaping;Work

PROJECT_TITLE: Defining neurobiological links between substance use and mental illness


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Drug Abuse (NIDA only);Mental Health;Neurodegenerative;Neurosciences;Substance Misuse

PI_NAMEs: KAHNT, THORSTEN  (contact)

PROJECT_TERMS: Adaptive Behaviors;addiction;Alzheimer's Disease;amnestic mild cognitive impairment;Anatomy;Area;Behavior;Behavioral;Blood;Body mass index;Brain;Chemical Structure;Code;Cognition;cognitive function;Cues;Decision Making;Dementia;design;Desire for food;Event;Food Intake Regulation;Functional Magnetic Resonance Imaging;Goals;Hormones;Human;Hypothalamic structure;Lateral;learned behavior;Learning;Magnetic Resonance Imaging;Metabolic hormone;midbrain central gray substance;Midbrain structure;mild cognitive impairment;Modeling;motivated behavior;neural;neuropsychiatric disorder;neuropsychiatry;neuroregulation;novel;Odors;Olfactory tract;Olfactory tubercle;Outcome;Participant;patient population;Population;Process;Publishing;Research;Research Project Grants;Resolution;response;Rewards;Role;Smell Perception;Structure;Substance Use Disorder;Techniques;Testing;tractography;Training;Transcranial magnetic stimulation;United States National Institutes of Health

PROJECT_TITLE: Neurocomputational mechanisms of learning and decision-making and their disruption in addiction


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Cocaine;Complementary and Integrative Health;Depression;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

PI_NAMEs: VENDRUSCOLO, LEANDRO  (contact)

PROJECT_TERMS: Acids;Acute;addiction;Adrenergic Agonists;Adrenergic Antagonists;Agonist;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol effect;alcohol exposure;alcohol response;alcohol sensitivity;Alcohol withdrawal syndrome;Alcohols;Analgesics;antagonist;Anti-Anxiety Agents;anti-depressive agents;Anxiety;Anxiety Disorders;anxiety-like behavior;base;Behavior;beta-2 Adrenergic Receptors;Biological Assay;biological systems;Blood alcohol level measurement;Brain;Brain Diseases;breath alcohol measurement;Buprenorphine;burden of illness;Butylene Glycols;Chronic;Clinical;clinical development;Clinical Trials;Cocaine;cocaine exposure;cocaine self-administration;Cocaine use disorder;Communication;CRF receptor type 1;Cross-Over Studies;cysteinyltyrosine;Data;Development;Diagnosis;disability;Dose;Drug Targeting;Drug usage;emotion regulation;endogenous opioids;Fatty acid glycerol esters;Female;Glutamates;Goals;heat stimulus;Heroin;Heroin Dependence;Hour;Human;Hyperalgesia;Infusion procedures;Intake;interdisciplinary approach;Interoception;Intoxication;intraperitoneal;Intravenous;kappa opioid receptors;Ketamine;ketogenic diet;Ketones;Link;Locomotion;lofexidine;male;Measures;mechanical stimulus;Mechanics;men;Mental Depression;Mental disorders;Metabotropic Glutamate Receptors;Methadone;Mission;MK801;Molecular;Monitor;Mood Disorders;Motivation;mu opioid receptors;Mus;N-Methyl-D-Aspartate Receptors;Naloxone;Naltrexone;National Institute of Drug Abuse;neural circuit;neuroadaptation;Neurobiology;neuron development;Neurons;Neuropeptides;Neurosciences;Neurotransmitters;Nociception;nociceptive response;non-opioid analgesic;norbinaltorphimine;Ondansetron;Opioid;Opioid agonist;Opioid Antagonist;Opioid Peptide;Opioid Receptor;opioid use;opioid withdrawal;Oral;Oral Administration;Oxytocin;Pain;Pain Measurement;pain sensitivity;Participant;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Physiological;Placebos;Play;Pre-Clinical Model;preclinical study;Prevention strategy;Protocols documentation;Questionnaires;Ramp;Rattus;receptor;Receptor Activation;Recording of previous events;Research;response;Role;Self Administration;Serotonin Receptors 5-HT-3;sex;Single-Blind Study;Stimulus;Stress;Substance Use Disorder;Sweetening Agents;Synaptic plasticity;System;Tail Suspension;Temperature;Testing;Therapeutic;United States Food and Drug Administration;Water;Wistar Rats;Withdrawal;Woman

PROJECT_TITLE: Stress and Addiction Neuroscience Unit


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Substance Misuse

PROJECT_TERMS: Address;Affect;Animal Model;Autopsy;Behavior;behavior test;Behavioral;Brain;Cells;Cognitive;cognitive testing;Corpus striatum structure;Data;Dimensions;Equipment;experimental study;Funding;Future;Genes;Hand;Hippocampus;HIV;HIV-associated neurocognitive disorder;Human;Impaired cognition;Impairment;improved;indexing;Individual;Individual Differences;Infection;Learning;Manuscripts;Measures;Microglia;Midbrain structure;Modeling;Molecular;National Institute of Drug Abuse;neural circuit;neural information processing;neural patterning;neuroinflammation;neurotoxicity;novel;patient population;Performance;pharmacologic;Population;Positioning Attribute;preconditioning;promoter;Proviruses;Rattus;Rodent Model;Sensory;Structure;Testing;Update;Work

PROJECT_TITLE: CHARACTERIZATION OF COGNITIVE INFERENCE IN A RODENT MODEL OF HIV-ASSOCIATED NEUROCOGNITIVE DISORDER


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Cannabinoid Research;Data Science;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse

PROJECT_TERMS: Address;Adherence;Affect;algorithm training;Algorithms;Artificial Intelligence;Attitude;Awareness;Behavior;Behavior monitoring;Behavioral;Behavioral Paradigm;Big Data;binge drinking;Biological Markers;Black race;Cannabis;cannabis craving;Cellular Phone;Classification;Clinical;clinical practice;Communication;Communities;comparative;Complex;Computational algorithm;Consumption;Data;Data Collection;Data Set;dating behavior;deep learning;demographics;Devices;digital;digital phenotyping;Ecological momentary assessment;effective intervention;Epidemic;Event;Face;feature selection;Formulation;gender minority;Goals;Gravitation;Health;health record;high risk behavior;high risk sexual behavior;HIV;HIV risk;HIV Seropositivity;Incidence;Individual;innovation;insight;Intervention;Language;Legal;Location;machine learning algorithm;marijuana legalization;marijuana use;marijuana user;Measures;men;Methodology;Modernization;Monitor;Moods;Oral;Outcome;Participant;Pattern;phenotypic data;Policies;pre-exposure prophylaxis;Prevalence;Research;Risk;Risk Behaviors;sex;Sex Behavior;Sexual and Gender Minorities;sexual encounter;sexual minority men;Sexual Partners;social media;Social support;substance use;Surveys;tailored messaging;Techniques;Technology;Time;tool;transmission process;United States;Unsafe Sex

PROJECT_TITLE: Digital Phenotyping & Deep Learning: Substance Use Impact on PrEP Adherence among Black Sexual and Gender Minorities


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Liver Disease;Opioid Misuse and Addiction;Opioids;Substance Misuse

PROJECT_TERMS: addiction;Address;Aging;Agonist;Albumins;alcohol comorbidity;Alcohol consumption;alcohol craving;alcohol effect;alcohol seeking behavior;alcohol use disorder;Alcoholic Liver Diseases;Alcohols;Aldosterone;Alkaline Phosphatase;antagonist;antiretroviral therapy;Anxiety;Area;Baclofen;behavioral and social science;Bilirubin;Biological Markers;Biomedical Research;Blood;Cardiovascular system;CD4 Lymphocyte Count;Chronic Disease;Clinical;clinical practice;Clinical Research;clinically relevant;co-infection;Cohort Studies;comorbidity;Consensus;Consumption;cost;cost effective;Country;Data;Data Science;Decision Making;Diagnosis;Dose;Drug Prescriptions;Drug usage;Early identification;Edema;Electronic Health Record;Environmental Risk Factor;Essential Hypertension;experience;experimental study;FDA approved;Female;Fentanyl;frailty;France;GABA-B Receptor;Goals;Health Benefit;health disparity;Heart failure;Hepatitis C co-infection;Hepatology;Hepatotoxicity;high risk sexual behavior;HIV;Hospitalization;Human;Hypokalemia;Impairment;improved;indexing;Individual;Intake;interest;International;Investigation;Literature;Liver Cirrhosis;Liver diseases;liver function;liver injury;male;Measures;Medical;Mental disorders;Meta-Analysis;Methods;Mineralocorticoid Receptor;Morbidity - disease rate;mortality;Motivation;Mus;Neurologic;novel;off-label use;Opioid;opioid misuse;opioid use;opioid use disorder;opioid withdrawal;Outcome;Pain;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacotherapy;physical conditioning;Physiological;Polypharmacy;Population;preclinical study;Primary Hyperaldosteronism;prospective;Prothrombin time assay;Psychiatry;Psychological reinforcement;Public Health;Publishing;randomized, clinical trials;Randomized, Controlled Trials;Rattus;Regulation;Reinforcement Schedule;Research;Research Priority;Risk;Risk Factors;RNA;Role;Safety;Self Administration;Series;Severities;Signal Transduction;social factors;Spironolactone;substance use;Substance Use Disorder;Symptoms;Testing;therapy adherence;Traction;transmission process;United States National Institutes of Health;vapor;Work;Workload

PROJECT_TITLE: Investigating the effects of novel medications for alcohol and substance use disorders in improving HIV-related outcomes and providing health benefits in people living with HIV.


NIH_SPENDING_CATS: Drug Abuse (NIDA only);HIV/AIDS;Neurosciences;Substance Misuse

PI_NAMEs: MICHAELIDES, MICHAEL  (contact)

PROJECT_TERMS: Brain;Cocaine;comorbidity;Dopamine;Drug Exposure;drug of abuse;experimental study;Exposure to;Gene Expression;Generations;Goals;Heroin;HIV;Human;Knowledge;Mediating;Metabolic Marker;molecular imaging;Monitor;Neuroimmune;neuroinflammation;neurotransmission;novel;Positron-Emission Tomography;Proteins;radioligand;Rat Transgene;Rattus;Reporter;Research;response;Rodent;therapeutic development;Therapeutic Intervention

PROJECT_TITLE: Longitudinal and noninvasive characterization of brain function and HIV expression in a novel HIV transgenic rat


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PROJECT_TERMS: Acceleration;addiction;Age;age related;Aging;aging brain;Alcohols;antiretroviral therapy;Brain;cerebral atrophy;Chronic;Chronology;cocaine use;Cognition;Cognitive;cognitive performance;cohort;comorbidity;conditioning;connectome;Control Groups;Data;Drug usage;Education;executive function;frontal lobe;Functional Magnetic Resonance Imaging;gray matter;Habits;Head;High Prevalence;high school;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV-associated neurocognitive disorder;Human;Image;Impaired cognition;improved;Individual;Investigation;Left;Magnetic Resonance Imaging;Manuscripts;Maps;Masks;Medial;men;Metabolism;mild cognitive impairment;Modeling;Motion;Motivation;MRI Scans;Neurobiology;Neurocognitive Deficit;neuroimaging;Nodal;Participant;patient subsets;Patients;Pattern;Persons;Population;Pre-Clinical Model;predictive modeling;Predisposing Factor;Preparation;Process;Regression Analysis;Research Project Grants;Rest;Rewards;risk mitigation;sex;Standardization;Statistical Data Interpretation;Structure;Structure of superior frontal gyrus;substance use;Substance Use Disorder;Sum;Testing;United States National Institutes of Health;Variant;Women's prevalence

PROJECT_TITLE: Impact of comorbidity of HIV infection and substance use disorder on brain aging and cognitive impairment


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Infectious Diseases;Neurosciences;Prevention;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

PROJECT_TERMS: Amendment;Behavior;Behavioral;Brain;Brain region;Chicago;Cocaine;Cocaine use disorder;cohort;Collaborations;community organizations;contingency management;Data;Decision Making;Drug usage;Functional Magnetic Resonance Imaging;Gambling;HIV;HIV Infections;HIV risk;Illinois;Impairment;Individual;Intervention;Iowa;Left;Maryland;Needle-Exchange Programs;Neuropsychology;neuroregulation;outreach;Pattern;Phase;Population;Prefrontal Cortex;protocol development;Protocols documentation;Punishment;recruit;Research Project Grants;response;Rewards;Risk;Risk Assessment;Risk Behaviors;Risk Taking;Sex Behavior;Substance Use Disorder;Testing;Time;Transcranial magnetic stimulation;treatment center;Universities;Visit;Work

PROJECT_TITLE: Reduction of HIV risk behavior with transcranial magnetic stimulation


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PROJECT_TERMS: Affect;Animals;antiretroviral therapy;Behavior;Behavior assessment;Brain;Brain region;Cell Nucleus;cell type;Cells;Central Nervous System;Clinical Research;Cocaine;cognitive testing;Collaborations;comorbidity;constitutive expression;cytokine;Development;differential expression;Disease;drug of abuse;Effectiveness;Elements;Embryonic Development;Enterobacteria phage P1 Cre recombinase;Evolution;Exposure to;falls;Gene Expression;Gene Expression Profile;Genes;Genetic Recombination;Genetic Transcription;Genome;glial activation;Glutamates;Goals;HIV;HIV Genome;HIV therapy;HIV-1;HIV-associated neurocognitive disorder;Homeostasis;Human;improved;Inflammation;Inflammatory;Inherited;Learning;Ligands;Location;Mediating;Metabolic;Methamphetamine;Methods;Microglia;Midbrain structure;Modeling;Molecular;Molecular Profiling;Monitor;nanoparticle;National Institute of Drug Abuse;Neurocognitive Deficit;Neuroglia;neuroinflammation;Neurons;Neuropathogenesis;neurotoxicity;NF-kappa B;novel;novel therapeutic intervention;Pathogenesis;Pathology;Pathway interactions;Physiological;Population;Positioning Attribute;Positron-Emission Tomography;Post-Transcriptional RNA Processing;preclinical study;Prefrontal Cortex;Production;Productivity;promoter;Proviruses;psychostimulant;rat genome;Rat Transgene;Rattus;receptor;Reporter;Reporting;response;RNA;RNA Processing;RNA Splicing;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;Sorting;stimulant exposure;Stimulus;Study models;Substance of Abuse;T-Lymphocyte;Testing;Time;Tissues;transcription termination;transcriptome;Transgenes;Transgenic Organisms;Viral;Viral Proteins;Viral reservoir;Virus;Virus Replication;Work

PROJECT_TITLE: Developing rat models of HIV-associated neurotoxicity and neuroinflammation


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: JIN, ALBERT J (contact)

PROJECT_TERMS: anti-cancer;Antineoplastic Agents;Area;Atomic Force Microscopy;bioimaging;Biological;Biological Sciences;Biomedical Research;biophysical techniques;Biophysics;Brain;Cell Line;Cells;cellular imaging;circumsporozoite protein;Clathrin;Collaborations;Collagen;Communication;Complex;Cytoskeleton;Development;DNA;efficacy study;Extracellular Matrix;Extramural Activities;Fiber;gang;Gel;Generations;genetic variant;glycosylation;HepG2;Image;Immune response;Immunologics;Immunotherapy;improved;In Vitro;insight;instrumentation;Investigation;macromolecule;Malaria;Malaria Vaccines;Malignant Neoplasms;Manuscripts;Mass Spectrum Analysis;mathematical analysis;mathematical model;mechanical properties;Medical;Membrane;Methodology;Methods;microscopic imaging;Microscopy;Microtubules;Molecular Structure;Morphology;Motility;multidisciplinary;nano;nanomechanics;nanomedicine;nanoparticle;nanoscale;Nanostructures;Nanotechnology;National Institute of Allergy and Infectious Disease;National Institute of Biomedical Imaging and Bioengineering;National Institute of Child Health and Human Development;National Institute of Neurological Disorders and Stroke;Neurons;Nitric Oxide;novel;novel vaccines;Optics;Organ;Parasites;Pathogenesis;peer;Peer Review;Photosensitizing Agents;Physiological;Plasmodium falciparum;Plasmodium vivax;preclinical efficacy;Property;protein crosslink;Proteins;Public Health;Publications;Publishing;Raman Spectrum Analysis;Reactive Oxygen Species;receptor mediated endocytosis;Recombinants;Research;research study;Sampling;Scientist;single molecule;Spectrum Analysis;Sporozoites;Synaptic Transmission;System;theranostics;Therapeutic;Tissues;trafficking;transmission-blocking vaccine;United States National Institutes of Health;vaccine candidate;Vaccines

PROJECT_TITLE: Biomedical Studies and Cellular Imaging via Atomic Force Microscopy


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Genetics;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Microbiome;Neurosciences;Prevention;Rare Diseases;Vaccine Related

ORG_NAME: NATIONAL EYE INSTITUTE

PI_NAMEs: CASPI, RACHEL R. (contact)

PROJECT_TERMS: Actinobacteria class;Active Immunization;Adopted;Adoptive Transfer;Affect;Agonist;Animal Model;Anti-Inflammatory Agents;Antibiotic Therapy;Antibodies;Antibody-drug conjugates;Antigen Presentation;Antigens;Arrestins;Aryl Hydrocarbon Receptor;Autoimmune Responses;autoimmune uveitis;Autoimmunity;Automobile Driving;Bioinformatics;Biological Markers;birdshot chorioretinitis;Cataract;CD6 antigen;Cell Differentiation process;Cells;Characteristics;Clinic;Clinical;clinical material;Collaborations;commensal microbes;Corynebacterium;cytokine;cytotoxic;Data;Dendritic Cells;Development;Disease;Ebola;Ebola Hemorrhagic Fever;engineered T cells;Engineering;Equilibrium;experience;Experimental Models;Eye;Eye diseases;fatty acid oxidation;FCGR3B gene;Firmicutes;Flow Cytometry;FOXP3 gene;Fusobacteria;gain of function mutation;Genes;Genetic;Germ-Free;Glycoproteins;Goals;gut microbes;gut microbiome;gut microbiota;Haplotypes;high dimensionality;Homeostasis;Host Defense;Human;human microbiota;IL17 gene;Immune;Immune response;Immune Tolerance;Immunity;Immunization;Immunologics;Immunology;Immunotherapy;improved;In Situ;In Vitro;in vivo;Individual;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;insight;Interleukin-1;interstitial retinol-binding protein;Intervention;Intestines;intraepithelial;Knock-in Mouse;Laboratories;Legal patent;lens;lens capsule;Lymphocyte;Lymphocyte Depletion;Macrophage;Manuscripts;Measurable;Mediating;Metabolic;Microbe;microbial;microbiome;microbiota;Modeling;Molecular;Molecular Mimicry;Monoclonal Antibodies;mouse model;Mucosal Immune Responses;mucosal site;Mucous Membrane;multiple omics;Mus;Mutation;Myeloid Cells;Nasopharynx;National Institute of Allergy and Infectious Disease;ocular surface;Oral cavity;Organism;pathobiont;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peptides;Peripheral Blood Mononuclear Cell;Phenotype;Population;Preparation;preservation;Process;Production;protective effect;receptor;reconstitution;Recovery;recruit;Regulatory T-Lymphocyte;response;Retina;retinal damage;RNA;Role;sensor;Signal Transduction;single-cell RNA sequencing;success;Surface;Survivors;T cell response;T-Cell Receptor;T-Lymphocyte;Therapeutic;Tissues;TLR2 gene;transcription factor;transcriptome;transcriptomics;Transgenic Mice;Uveitis;Vagina;Viral Load result;Viremia;Vision;Volatile Fatty Acids;γδ T cells

PROJECT_TITLE: Genetic, Cellular and Molecular Mechanisms in Autoimmunity to Retina


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: WISTOW, GRAEME J (contact)

PROJECT_TERMS: age related;age-related disease;Aging;amyloid formation;Animal Model;Binding Proteins;biophysical properties;Blindness;Cataract;Cell Maturation;Collaborations;Cryoelectron Microscopy;Crystallins;Cytoskeleton;Defect;Degenerative Disorder;Deposition;Development;Enzymes;Eye;Failure;Family;gamma-Crystallins;Genes;Human;human model;Inflammatory Response;Intermediate Filaments;intermolecular interaction;lens;Lens Fiber;Molecular Structure;Mus;Mutate;Pathway interactions;Process;Processed Genes;Proteins;recruit;Refractive Indices;Retina;Role;Stress;Swelling;Tissues;Work

PROJECT_TITLE: Molecular Structure and Function of Crystallins


NIH_SPENDING_CATS: Biotechnology;Dietary Supplements;Eye Disease and Disorders of Vision;Genetics;Neurosciences

PI_NAMEs: REDMOND, T. MICHAEL  (contact)

PROJECT_TERMS: 3' Untranslated Regions;Affect;All-Trans-Retinol;Animal Model;Antioxidants;autosome;Belgium;Beta Carotene;Binding;Biochemical;biophysical analysis;Blindness;Carotenoids;Catalysis;Cell Culture System;Cell Culture Techniques;Cell Line;Cell model;Cell Nucleus;Cells;Chemistry;chromophore;Codon Nucleotides;Collaborations;Complement;Cultured Cells;Cysteine;Databases;Development;Dioxygenases;Disease;Dissection;Endoplasmic Reticulum;Enzymes;experimental study;FDA approved;Gene Modified;gene replacement therapy;Genes;Genetic;Genetic Transcription;Goals;Green Fluorescent Proteins;Health;Human;in vivo;induced pluripotent stem cell;Inherited;interest;Internal Ribosome Entry Site;Isomerase;Isomerism;Knock-in Mouse;Knock-out;Learning;Lutein;Mammals;man;Manuscripts;Mass Spectrum Analysis;Membrane;Messenger RNA;Metabolic;Metabolic Pathway;Metabolism;Methods;Modeling;Molecular;Molecular Biology;Molecular Genetics;mouse model;Mus;Mutate;Mutation;National Center for Advancing Translational Sciences;Niacinamide;North America;novel;Open Reading Frames;operation;Oxygenases;palmitoylation;Pathogenicity;Pathway interactions;patient derived induced pluripotent stem cells;Patients;pattern dystrophies;Peptides;Phenotype;photoprotection;Photoreceptors;Physiology;Play;Point Mutation;Process;promoter;Protein Biochemistry;protein expression;Proteins;Pyruvate;Regulation;Reporting;Research;response;Retina;Retinal Dystrophy;Retinal Pigments;Retinitis Pigmentosa;Retinoic Acid Receptor;Retinoids;retinol isomerase;RNA Splicing;Role;RPE65 protein;sensor;small molecule;small molecule inhibitor;structural biology;Structure;Structure of retinal pigment epithelium;Therapeutic;Transcriptional Regulation;Transfection;Translational Regulation;Translations;Variant;vector;Vision;visual cycle;Vitamin A;Work;Xanthophylls

PROJECT_TITLE: Molecular Biology Of Outer Retina-specific Proteins


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Eye Disease and Disorders of Vision;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences

PI_NAMEs: EGWUAGU, CHARLES E (contact)

PROJECT_TERMS: Adoptive Transfer;Adverse effects;Autoimmune Diseases;autoimmune uveitis;B-Lymphocytes;Binding;Blood-Retinal Barrier;Cell secretion;Cells;chronic inflammatory disease;CNS autoimmune disease;CTLA4 gene;cytokine;Dimerization;exhaustion;exosome;Family;Growth;Immune;Immunosuppression;in vivo;Inflammatory;Interleukin-10;Interleukin-12;interleukin-23;Lymphocyte Function;Mediating;member;Membrane;mouse model;Multiple Sclerosis;Mus;neuroinflammation;Pathogenesis;Physiological;Play;Population;programmed cell death protein 1;Protein Secretion;receptor;Regulatory T-Lymphocyte;Role;T-Lymphocyte;Therapeutic;Uveitis

PROJECT_TITLE: Role of IL-12 family cytokines in autoimmune Uveitis


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: HEJTMANCIK, JAMES F. (contact)

PROJECT_TERMS: Affect;Complex;Corneal dystrophy;Data Set;database of Genotypes and Phenotypes;Diabetic Retinopathy;Diagnosis;Disease;Eye diseases;Family;Functional disorder;gene product;Genes;Genetic;genetic linkage analysis;Glaucoma;Goals;Hereditary Disease;Human;human disease;improved;Inherited;insight;interest;Laboratories;Lead;Leber's amaurosis;Molecular;Mutation;Myopia;Patient Care;Physiology;positional cloning;Prevention;recruit;Retinal Dystrophy;Retinitis Pigmentosa;snowflake vitreoretinal degeneration;Structure-Activity Relationship;Visual;visual processing;Visual System

PROJECT_TITLE: Inherited Ocular Diseases


NIH_SPENDING_CATS: Autoimmune Disease;Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TERMS: Animal Model;Apoptosis;autoimmune uveitis;B-Lymphocyte Subsets;B-Lymphocytes;Cell Proliferation;Cells;Cellular Metabolic Process;Cessation of life;CISH gene;cytokine;Cytoplasm;Data;Disease;Embryonic Development;Eye;Genetic Transcription;human model;Immunity;Immunosuppression;Inflammation;Inflammatory;Inflammatory Response;Insecta;Interferons;Interleukin-10;IRF4 gene;Lymphocyte;Lymphoid;Lymphoid Cell;Lymphoid Tissue;Mammals;Mediating;Metabolic;Metabolism;Mus;neuroprotection;Pathogenicity;Pathologic;Pathway interactions;Patients;Physarum polycephalum;Physiological Processes;Proteins;PTPN6 gene;Rattus;Research;Resistance;response;Retina;Role;Scleritis;Signal Transduction;STAT3 gene;T-Lymphocyte;transcription factor;Transgenic Mice;Uveitis;Zinc Fingers

PROJECT_TITLE: Suppressors of Cytokine Signalling (SOCS) have Neuroprotective  Roles in Retina


NIH_SPENDING_CATS: Aging;Clinical Research;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Pediatric

PROJECT_TERMS: age related;Aging;Apoptosis;arm;Bacteria;Biological;Biological Models;C-Peptide;Candidate Disease Gene;Cataract;Characteristics;Clinical;Code;Complex;congenital cataract;Crystalline Lens;Crystallins;design;Development;Diagnosis;Disease;disease-causing mutation;eye formation;Family;Functional disorder;gamma-Crystallins;gene function;gene product;Gene Structure;Genes;Genetic;genetic linkage analysis;Goals;Greek;In Vitro;Inherited;insight;interest;Investigation;lens;Lens development;Lens Opacities;lens transparency;Lesion;Modification;Molecular;Molecular Biology;Molecular Genetics;mutant;Mutate;Mutation;mutation screening;Pathologic;Pathway interactions;physical mapping;Physiology;Prevention;protein function;protein structure;Proteins;RNA;Stress;Structure;System;Systems Development;Technology;Transgenic Mice;Vision;Work

PROJECT_TITLE: Clinical/molecular Studies In Families With Congenital Or Hereditary Cataracts


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: BECERRA, S. PATRICIA  (contact)

PROJECT_TERMS: Acetylation;Affinity;Affinity Chromatography;Age Months;Age related macular degeneration;Aging;Amino Acid Substitution;Amino Acids;Ammonium Sulfate;Angiogenesis Inhibitors;Angiography;Animal Model;Anions;arrestin3;BCL2 gene;Binding;Biochemical;Biochemistry;Biological Assay;BODIPY;Buffers;C-terminal;Cations;Cell Aging;Cell Death;Cell Line;Cell Survival;Cells;cellular transduction;Complementary DNA;complex R;Confocal Microscopy;Corneal Neovascularization;Crossbreeding;CRX protein;cytokine;Deposition;design;Detergents;Development;Electroretinography;Escherichia coli;Evaluation;Exclusion;Exhibits;expression vector;Eye;Eyedrops;Family;Freezing;Gel;Gene Expression;Genes;Genetic Engineering;Genetic Transcription;Genotype;Histology;Histones;Hour;Human;Hydrolysis;IL6 gene;Immunofluorescence Immunologic;Immunofluorescence Microscopy;In Situ Nick-End Labeling;in vitro Assay;in vivo;Inflammation;Inflammatory;Inherited;inhibitor;Interest Group;Interferon Type II;Interleukin-6;Knockout Mice;Lactones;life span;Light;Link;Lipase;lipid metabolism;Lipids;Magnesium Chloride;Maintenance;Mammals;Measures;Mediating;member;Membrane;milligram;Modification;Molecular;Molecular Sieve Chromatography;molecular size;Monitor;Morphology;mouse model;Mus;Mutagenesis;mutant;N-terminal;Neoplasm Metastasis;Neuronal Differentiation;neuronal survival;neuroprotection;Nuclear;Opsin;overexpression;Oxidative Stress;peptide chemical synthesis;Peptides;Phospholipase;Phospholipase A1;Phospholipase A2;Phospholipids;Photoreceptors;pigment epithelium-derived factor;pigment epithelium-derived factor receptor;Play;Polyacrylamide Gel Electrophoresis;postnatal;Precipitation;prevent;PRKCA gene;Process;Production;protective effect;protein purification;protein structure;Proteins;Quantitative Reverse Transcriptase PCR;Recombinants;Research;Retina;Retinal Cone;retinal damage;Retinal Degeneration;retinal ischemia;Retinal Photoreceptors;Reverse Transcriptase Polymerase Chain Reaction;rho;Rhodopsin;Role;Sampling;screening;Serpin Superfamily;sex;Shock;Signal Transduction;Solubility;Stains;Structure of retinal pigment epithelium;Synaptophysin;Testing;Thick;TNF gene;Transcript;transcription factor;Transmission Electron Microscopy;Triglycerides;tumorigenesis;Variant;Vision;Work;zaprinast

PROJECT_TITLE: Role of Protein Interactions in Retina Development and Function


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurosciences

PI_NAMEs: TOMAREV, STANISLAV I (contact)

PROJECT_TERMS: Adult;Affect;Alzheimer's Disease;Amacrine Cells;AMPA Receptors;Amyotrophic Lateral Sclerosis;Binding;Binding Proteins;Biological;Biological Assay;Brain;Cell Physiology;cell type;Cells;Chronic;Communication;comparative;Complex;Data;Defect;Dependovirus;Development;differential expression;Dimerization;Docking;Electroretinography;Epilepsy;Excision;extracellular;Extracellular Matrix;Extracellular Protein;Eye;Eye Development;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene set enrichment analysis;Genes;Genetic Transcription;Glaucoma;Glutamate Receptor;Glutamates;Glycoproteins;Goals;Huntington Disease;Immunoprecipitation;In Vitro;in vivo;Kinetics;Knock-out;Knockout Mice;Maps;Measures;Mediating;Modeling;Modification;Molecular;Molecular Genetics;Molecular Mechanisms of Action;monomer;Mus;Mutation;Nervous System Disorder;olfactomedin;overexpression;Parkinson Disease;Pathologic;Pathology;Pathway interactions;pathway tools;Pattern;Photoreceptors;Physiology;Play;Population;Process;protein folding;protein function;protein protein interaction;Proteins;Retina;Retinal Ganglion Cells;Role;Sampling;Synapses;Testing;Tissue-Specific Gene Expression;Tissues;Transcription Process;transcriptome sequencing;Transfection;Wild Type Mouse

PROJECT_TITLE: Molecular Genetics Of Early Eye Development


PROJECT_TERMS: Adoptive Transfer;Adverse effects;Autoimmunity;Brain;Cells;Cerebellar Ataxia;CNS autoimmune disease;cytokine;Development;Disease;Encephalomyelitis;Experimental Autoimmune Encephalomyelitis;experimental study;extracellular;Eye;Growth Factor;Homologous Gene;IL17 gene;Immune response;Immunosuppression;Immunotherapy;Inflammatory;Interferon Type II;Lymphocyte;Mediating;mouse model;Multiple Sclerosis;Mus;nanobodies;Paralysed;Pathogenicity;Pathway interactions;pharmacologic;recruit;Regulation;Signal Transduction;Spinal Cord;STAT protein;STAT1 gene;STAT3 gene;T-Lymphocyte;Th1 Cells;Therapeutic

PROJECT_TITLE: Regulation of JAK/STAT  pathways in the eye


NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PROJECT_TERMS: 3-Dimensional;Aftercare;Animal Model;Axon;Biological Process;Blindness;bone marrow mesenchymal stem cell;Cell Culture Techniques;Cell Death;Cell Line;Cell Proliferation;Cell Survival;cell type;Cells;Chromosome Mapping;Code;comparative;comparison control;Conditioned Culture Media;Cytoprotection;Data;Data Set;density;Dermal;differential expression;Engineering;exosome;extracellular vesicles;Fibroblasts;Fractionation;Gene set enrichment analysis;Glaucoma;Growth Factor;Hour;Human;human embryonic stem cell line;improved;In Vitro;in vivo;induced pluripotent stem cell;intravitreal injection;Investigation;Mammals;Messenger RNA;Methods;MicroRNAs;microvesicles;miRNA expression profiling;Molecular;morphometry;mouse model;Mus;Natural regeneration;Neurites;neuroprotection;Ontology;Pathway Analysis;Pathway interactions;Play;Population Heterogeneity;Property;Proteins;restoration;Retina;Retinal Ganglion Cells;RNA;Role;Sampling;Signal Transduction;Source;Stains;Testing;therapeutic candidate;therapeutic target;three dimensional cell culture;transcriptome sequencing;Trees;Tubulin;Ultracentrifugation;Undifferentiated

PROJECT_TITLE: Molecular Mechanisms Of Glaucoma


NIH_SPENDING_CATS: Autoimmune Disease;Eye Disease and Disorders of Vision;Immunotherapy;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PROJECT_TERMS: Adrenal Cortex Hormones;Adverse effects;Allogenic;B-Lymphocytes;Cells;chronic graft versus host disease;CNS autoimmune disease;cytokine;Development;Disease;Dose;effective therapy;Family;graft vs host disease;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Homologous Transplantation;Immune;Immunity;Immunotherapy;Inflammatory;Interleukin-10;Interleukin-12;Interleukins;member;mortality;Mus;Population;Regulatory T-Lymphocyte;Risk;Severities;standard of care;Steroids;T-Lymphocyte;Therapeutic;Uveitis

PROJECT_TITLE: Development of Immunologic therapies against uveitis


NIH_SPENDING_CATS: Autoimmune Disease;Eye Disease and Disorders of Vision;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PROJECT_TERMS: Adoptive Transfer;Allogenic;Autoimmune Diseases;B-Lymphocytes;Cells;Cellular immunotherapy;CNS autoimmune disease;cytokine;Development;Disease;exosome;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Homeostasis;Homologous Transplantation;Immune;Immunosuppression;Immunotherapy;Inflammation;Inflammatory;Interleukin-10;Lymphocyte;mortality;Mus;nanobodies;Patients;Regulation;Signal Pathway

PROJECT_TITLE: Mechanisms of immune homeostasis and regulation of intraocular inflammation


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Eye Disease and Disorders of Vision;Heart Disease;Heart Disease - Coronary Heart Disease;Hypertension;Neurosciences;Prevention

PI_NAMEs: CHEW, EMILY Y (contact)

PROJECT_TERMS: Blood Glucose;Blood Pressure;blood pressure control;British;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cataract Extraction;Cessation of life;clinical effect;Clinical Treatment;Confidence Intervals;Congestive Heart Failure;conventional therapy;Coronary Arteriosclerosis;Coronary heart disease;cytokine;Data;design;Diabetes Mellitus;Diabetic Retinopathy;Dietary intake;Dyslipidemias;Early treatment;Eye;Fenofibrate;follow-up;Fundus;Fundus photography;glycemic control;Glycosylated hemoglobin A;Goals;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Hospitalization;hypertension control;Journals;LDL Cholesterol Lipoproteins;Lipids;Low-Density Lipoproteins;Manuscripts;Masks;Measurement;Medical;Microvascular Dysfunction;mortality;Myocardial Infarction;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;Odds Ratio;ophthalmic examination;Ophthalmology;Outcome;Outcome Measure;Paper;Participant;participant enrollment;Patients;Persons;Phase;Placebos;posters;primary endpoint;primary outcome;progression risk;Protocols documentation;Publishing;Randomized;Randomized Controlled Clinical Trials;randomized, clinical trials;recruit;revascularization;Sample Size;Schedule;secondary analysis;secondary outcome;Serum;Severities;Simvastatin;stereoscopic;Stroke;Time Study;treatment arm;Triglycerides;Update;Visual Acuity;Writing

PROJECT_TITLE: ACCORD (Action to Control Cardiovascular Risk in Diabetes)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Parkinson's Disease

PI_NAMEs: HIKOSAKA, OKIHIDE  (contact)

PROJECT_TERMS: addiction;Anatomy;Animals;Anterior;Association Learning;Basal Ganglia;Basal Ganglia Diseases;Behavior;Behavior Control;Behavioral inhibition;Behavioral Mechanisms;Brain;Brain Diseases;Caring;Cerebral cortex;Cluster Analysis;cognitive control;Corpus striatum structure;Dedications;Dopamine;dopaminergic neuron;Eye Movements;Face;Familiarity;flexibility;Functional disorder;Goals;Habenula;Human;Image;Impairment;improved;information processing;Involuntary Movements;Lateral;Link;long term memory;Macaca;Medial;Mediating;Mental Depression;Methods;Monkeys;Motivation;motor control;Motor output;Motor Skills;Movement;neural;Neurons;nonhuman primate;Output;Parkinson Disease;pars compacta;Pathway interactions;Patients;Pattern;Persons;Play;Primates;Proactive Inhibition;Process;Reactive Inhibition;Recording of previous events;Research;reward processing;Rewards;Role;sample fixation;Sensory;Short-Term Memory;Signal Transduction;social;Social Behavior;Speed;Stimulus;Substantia nigra structure;Tail;Visual;visual stimulus;Work;Writing

PROJECT_TITLE: Neuronal networks for control of eye movement


NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences

PROJECT_TERMS: access restrictions;Age related macular degeneration;Aging;Animal Model;Antibodies;Bibliography;biological adaptation to stress;Blindness;Bruch's basal membrane structure;calcification;Calcium;capillary bed;Cell Culture System;Cell Culture Techniques;Cell model;Cells;Cholesterol;Collaborations;Deposition;deprivation;Development;Drusen;experimental study;Eye;Eye Development;FDA approved;functional genomics;Gene Expression Profiling;Genes;geographic atrophy;Health Personnel;Human;Hydroxyapatites;knock-down;Knockout Mice;Laser injury;Lesion;mineralization;Modeling;Morphology;mouse model;Mus;Nonexudative age-related macular degeneration;novel;Pathway interactions;patient population;Pharmaceutical Preparations;Printing;Process;Proteins;Publishing;release of sequestered calcium ion into cytoplasm;Retina;Role;RPE65 protein;Serum;Small Interfering RNA;Structure of retinal pigment epithelium;Techniques;Testing;therapeutic evaluation;Therapeutic Intervention;Time;transcriptome sequencing;Transgenes;Transgenic Mice;Up-Regulation;Validation;Vision;Work;wound;wound healing

PROJECT_TITLE: Functional Analysis of Novel Genes in Eye Development and Vision


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Prevention;Rare Diseases

PROJECT_TERMS: adenovirus mediated delivery;Affinity;Agarose Chromatography;Age;age group;Age Months;Aging;Albumins;Amino Acid Substitution;Amino Acids;Animal Model;beta-Galactosidase;Binding;Blood specimen;C-terminal;Cell Death;Cell Nucleus;Cessation of life;chemical synthesis;Choroid;Collaborations;Cornea;Cryoultramicrotomy;diagnostic assay;diagnostic tool;Disease;DNA Damage;Dose;Drusen;efficacy evaluation;Electroretinography;Engineering;Enzyme-Linked Immunosorbent Assay;Evaluation;Exhibits;extracellular;Eye;Eyedrops;Family suidae;Fundus photography;Genes;Goals;Heterozygote;Histologic;Histology;Human;Immunofluorescence Immunologic;improved;In Situ;in vivo;in vivo Model;in vivo monitoring;Internal Ribosome Entry Site;Knockout Mice;Lipids;Measures;Membrane;Modification;Monitor;Morphology;mouse model;Mus;Mutation;N-terminal;National Heart, Lung, and Blood Institute;novel therapeutics;Nuclear;Organoids;Oxidative Stress Induction;Pathway interactions;Patients;Penetration;Peptides;Phosphatidylserines;Phospholipase;Phospholipids;Phosphorylation;photoreceptor degeneration;Photoreceptors;pigment epithelium-derived factor;pigment epithelium-derived factor receptor;Plasma;prevent;receptor;Regulation;Retina;Retinal Diseases;Retinitis Pigmentosa;rho;Rhodopsin;RNA;Role;Safety;Sampling;senescence;Serpins;Stains;Structure of retinal pigment epithelium;Therapeutic;Thick;Tight Junctions;Time;Tissues;vector;Visual;Western Blotting;Wild Type Mouse;Zinc

PROJECT_TITLE: Therapeutics for the chorioretina


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences

PROJECT_TERMS: accurate diagnosis;Affect;Age related macular degeneration;amino acid metabolism;Area;Biochemistry;Biogenesis;Bioinformatics;Biological Assay;Biological Markers;Biology;biomarker identification;Blood Circulation;Catalogs;Cell Culture Techniques;Cell Line;Cell Physiology;Cell Therapy;Cells;Cellular biology;Characteristics;Citric Acid Cycle;cohort;Collaborations;Crista ampullaris;Cultured Cells;Darkness;Data;Diagnosis;differential expression;Differentiation Antigens;Disease;Early Diagnosis;Electron Transport;Enzyme-Linked Immunosorbent Assay;Etiology;experimental study;Extramural Activities;Eye;Functional disorder;functional genomics;Future;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Heterogeneous-Nuclear Ribonucleoprotein L;High Pressure Liquid Chromatography;Human;Immunoassay;Immunology;Immunoprecipitation;In Situ Hybridization;in vivo;Inflammation;Inflammatory;interest;Isomerism;knock-down;Laboratories;Lead;Lipids;Lysosomes;Mass Spectrum Analysis;Melanosomes;MERTK gene;Messenger RNA;Metabolic Pathway;Methods;MicroRNAs;Mitochondria;Modeling;Modernization;Molecular Biology;Molecular Structure;Monitor;Nerve Degeneration;Neurobiology;Niacinamide;Nucleic Acids;overexpression;Oxidative Phosphorylation;Pathologic;Pathology;Pathway interactions;Pattern;Peptides;Phenotype;Physiology;Pigmentation physiologic function;Plasma;Plasma Proteins;Play;Probability;Process;Proliferative Vitreoretinopathy;protein biomarkers;protein expression;Protein Secretion;Proteins;Proteome;Proteomics;Protocols documentation;Publications;Pyruvate;Pyruvate Metabolism Pathway;Reaction;Regulator Genes;repaired;Research;Research Personnel;Resolution;respiratory;response;Retina;Retinal Degeneration;Retinoids;Retinol Binding Proteins;Risk;RNA;Role;RPE65 protein;Sampling;Signal Pathway;Signal Transduction;Smooth Endoplasmic Reticulum;stoichiometry;Stress;Structure of retinal pigment epithelium;Supplementation;Testing;Transcript;transcriptome sequencing;TRPM1 gene;Untranslated RNA;Up-Regulation;Validation;visual cycle;Western Blotting;WNT Signaling Pathway;Writing

PROJECT_TITLE: Signaling in the retina and retinal pigment epithelium


NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Nutrition

PI_NAMEs: SWAROOP, ANAND  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Age;Age Months;age related changes;age related decline;Age related macular degeneration;Aging;aging related;Amino Acids;Animals;ATAC-seq;Autopsy;BACH1 gene;beta-Chemokines;Biology;Birds;Birth;Blindness;Brain;Cell Communication;cell type;Cells;Central Nervous System;Cessation of life;Chordata;Chromatin;Chromatin Loop;Co-Immunoprecipitations;Data;Data Set;Defect;design;Development;Diet;Dimerization;Disease;disorder of macula of retina;DNA;Elderly;Enhancers;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Evolution;Exhibits;experimental study;Eye;Fatty acid glycerol esters;Functional disorder;Gene Expression;Gene Expression Regulation;gene regulatory network;Gene Targeting;Genes;Genetic;genetic signature;Genetic Transcription;Genetic Variation;Genome;genome wide association study;Genomics;Genotype;Glaucoma;glucose metabolism;Glycemic Index;Glycolysis;Goals;Hi-C;Histones;Homeostasis;Homologous Gene;Human;Individual;induced pluripotent stem cell;Inherited;insight;Investigation;Knockout Mice;Life;Ligands;Lighting;Link;Lysine;Maintenance;Maps;Mediating;Mediterranean Diet;Metabolism;Methods;Molds;Molecular;mouse model;Mus;Natural regeneration;Neurons;novel;Nutritional;Organoids;Pathogenesis;Pathway interactions;Patients;Peripheral Nervous System;Phenotype;Photoreceptors;Physiological;Post-Translational Protein Processing;postmitotic;Predisposition;Primary Open Angle Glaucoma;Production;promoter;Promoter Regions;Protein Isoforms;Proteins;Regulation;Regulatory Element;Regulatory Pathway;Reporting;Resolution;response;Retina;Retinal Cone;Retinal Diseases;retinal neuron;Retinal Photoreceptors;retinal rods;RNA Splicing;RNA-Binding Proteins;Rod;Role;Sampling;sex;Signal Pathway;single-cell RNA sequencing;spatiotemporal;Specific qualifier value;stem cell organoids;subretinal injection;Synaptic Potentials;synaptogenesis;Testing;therapy design;Time;tool;Trabecular meshwork structure;Transcriptional Regulation;transcriptome;transcriptome sequencing;transmission process;Variant;Vision;Visual Acuity;visual information;Vitamin B Complex;yeast two hybrid system;Yeasts

PROJECT_TITLE: Genetic and epigenetic regulation of retinal development, aging and evolution


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Human Genome;Pediatric

PI_NAMEs: BROOKS, BRIAN  (contact)

PROJECT_TERMS: Affect;Alleles;Anophthalmos;Biological Assay;Blindness;Candidate Disease Gene;candidate identification;Cells;Child;Chromosome 13;Clinical;clinical care;Clinical Data;cohort;Coloboma;Congenital Abnormality;CRISPR screen;CRISPR/Cas technology;Data;Defect;Development;Developmental Gene;Developmental Process;DNA Sequence Rearrangement;dosage;Embryology;Enrollment;Exhibits;exome;experimental study;Eye;Eye Development;Failure;Family;Family history of;FAT gene;First Pregnancy Trimester;Funding;Gene Expression;Genes;Genetic;Genetic Counseling;genetic disorder diagnosis;genetic epidemiology;genetic testing;genome editing;genome sequencing;Genomics;Genotype;Goals;Habits;Health;Heterozygote;Human;human disease;In Vitro;in vivo;Individual;Inherited;inhibitor;Institutional Review Boards;integration site;Iris;Junk DNA;Knowledge;Laboratory Study;Life Style;malformation;Mediating;Methods;Microphthalmos;Molecular;Molecular Diagnostic Testing;Mothers;mouse model;Mus;mutant;Mutation;novel;Nuclear;ophthalmic examination;optic stalk;Optics;Parents;Participant;Pathway interactions;Patient Care;Patients;Phenotype;population based;Pregnancy;Prevention;Protocols documentation;Publishing;Questionnaires;recruit;Registries;Reporting;Repression;Research;Retina;Role;screening;Signal Pathway;Signal Transduction;Signaling Protein;Site;Surface;Syndrome;Telephone;Test Result;Texas;transcriptome sequencing;Transgenes;Transgenic Organisms;United States National Institutes of Health;Variant;Vascular Endothelial Growth Factors;whole genome;Work;Zebrafish

PROJECT_TITLE: The Genetics of Uveal Coloboma


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PROJECT_TERMS: adenovirus mediated delivery;Adult;Albinism;Amblyopia;Autophagocytosis;autosome;Axon;Biology;Blindness;Cells;Characteristics;Child;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Defect;Development;differentiation protocol;disease-in-a-dish;Dose;Early treatment;experience;Eye;FDA approved;Fibroblasts;ganglion cell;gene replacement;gene replacement therapy;gene therapy;Genes;Glare;Goals;Hair;High Pressure Liquid Chromatography;high-throughput drug screening;Human;Hypopigmentation;improved;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;induced pluripotent stem cell technology;inhibitor;Length;Libraries;macula;Measures;Mediating;Melanins;Melanosomes;Modeling;Monophenol Monooxygenase;Morphology;mouse model;Mus;National Center for Advancing Translational Sciences;Natural Products;Oculocutaneous Albinism;Oculocutaneous albinism type 1;Operative Surgical Procedures;Optic Chiasm;Oral;orbit muscle;Pathogenesis;Pathologic Nystagmus;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Phenotype;Photophobia;Physiology;Pigmentation physiologic function;Pilot Projects;postnatal;Proteins;Rattus;Refractive Errors;Research;response;Role;Skin;small molecule;Structure of retinal pigment epithelium;Testing;Tissues;Validation;Vision;vision aid;visual cycle;Visual impairment;Work;Zebrafish

PROJECT_TITLE: Understanding the pathogenesis of and identifying treatments for albinism


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Genetics

PI_NAMEs: SERGEEV, YURI  (contact)

PROJECT_TERMS: 3-Dimensional;Achievement;Active Sites;Affect;age-related disease;Aging;AKT2 gene;Alleles;Amino Acid Sequence;Amino Acids;Anabolism;Anterior;Behavior;Binding;Biochemical;Biochemical Reaction;Biochemistry;Biophysics;Carboxylic Acids;Cells;Clinical;Clinical Research;Co-Immunoprecipitations;Compensation;Complex;Computer Models;Computer Simulation;Cysteine;Cytosolic Phospholipase A2;Data;Databases;dimer;Disease;disease phenotype;DNA Sequence Alteration;Docking;dopaquinone;Elements;Engineering;enzyme activity;enzyme substrate;Enzymes;Exhibits;experimental study;Eye;Eye diseases;flexibility;Free Energy;Functional disorder;Gait abnormality;Genes;Genetic;Genetic Annotation;genetic variant;Genotype;genus Solanum;Goals;Hair;Hereditary Eye Diseases;high-throughput drug screening;Homology Modeling;Human;Hydrolase;Hydroxylation;Hypopituitarism;improved;in silico;In Vitro;in vitro activity;Indolequinones;Indoles;Inherited;insight;interest;Investigation;Knowledge;Ligand Binding;Ligands;Light;Link;Lipids;Melanins;Metabolic Pathway;Methods;Missense Mutation;Modeling;models and simulation;Molecular;Molecular Chaperones;Molecular Conformation;molecular dynamics;molecular modeling;Monophenol Monooxygenase;Mutagenesis;mutant;Mutation;neuropathy target esterase;next generation sequencing;overexpression;oxidation;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Play;preference;Preventive therapy;Process;Production;programs;protein expression;protein misfolding;protein protein interaction;protein structure;protein structure function;Proteins;Pseudomonas aeruginosa;Reaction;Recombinant Proteins;Recombinants;Research;Role;Sequence Homologs;Severities;Severity of illness;simulation;small molecule;Standardization;Structure;Substrate Interaction;Sum;Technology;theories;therapeutic target;Thermodynamics;Tissues;tool;Tyrosine;Variant;Visual impairment;Visual System;Water;web site;Work

PROJECT_TITLE: Proteins From Hereditary Eye Diseases: In silico and Experimental Studies


NIH_SPENDING_CATS: Biotechnology;Diabetes;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PI_NAMEs: LI, WEI  (contact)

PROJECT_TERMS: Animal Model;Animals;Carrier Proteins;Cells;Chromatin;coping;Cornea;experience;experimental study;exportin 1 protein;Genetic Transcription;Genomics;Health;Hibernation;Human;human stem cells;Impairment;Importins;improved;in vivo;induced pluripotent stem cell;insight;interest;Intervention;islet;Larva;Life;Metabolic;Metabolic stress;Metabolism;Modeling;Modification;Mus;natural hypothermia;novel strategies;Nuclear;Nuclear Pore Complex Proteins;Obese Mice;Organ Preservation;Outcome;Pancreas;Pathologic;Play;practical application;Prediabetes syndrome;preservation;Preservation Technique;Proteomics;Retina;Retinal Diseases;Role;severe injury;Spermophilus;stem cell model;Sumoylation Pathway;Surveys;System;Temperature;Temperature Sense;Therapeutic;therapeutic target;Tissues;transcription factor;transcriptome sequencing;Work;Zebrafish

PROJECT_TITLE: Adaptive changes of the ground squirrel retina during hibernation


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Macular Degeneration;Natural Products;Neurodegenerative;Neurosciences;Nutrition;Prevention

PROJECT_TERMS: Adverse effects;Age;age related;Age related macular degeneration;Antioxidants;Artificial Intelligence;Ascorbic Acid;Beta Carotene;Blindness;Blood specimen;Case Study;Cataract;Categories;Clinical;clinical center;Clinical Trials;cohort;Copper;Data;deep learning;design;Development;Disease;Disease Progression;Documentation;Dose;Elderly;Enrollment;Evaluation;Event;Eye diseases;follow-up;Follow-Up Studies;Formulation;Fundus;Fundus photography;Goals;Individual;Intake;lens;Literature;logarithm;Lutein;macula;Manuscripts;Multicenter Trials;Natural History;Nutritional;Omega-3 Fatty Acids;ophthalmic examination;oral supplementation;Participant;Peer Review;Persons;Phase;Photography;Polyunsaturated Fatty Acids;Population;population based;Prognosis;Protocols documentation;Publishing;randomized, clinical trials;Recommendation;Reporting;Risk;Risk Factors;Sampling;Telephone;Visit;Visual Acuity;Vitamins;Xanthophylls;zeaxanthin;Zinc

PROJECT_TITLE: Age-Related Eye Disease Follow-up Study (AREDS) Follow-up Study


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Usher Syndrome

PI_NAMEs: LI, TIANSEN  (contact)

PROJECT_TERMS: 3D Print;Address;Adopted;Affect;Age;Ally;Animal Model;Animal Welfare;Apical;Area;Atmosphere;Attention;Axon;axon regeneration;axonal pathfinding;Biocompatible Materials;Biological;Biological Models;Bioreactors;Blindness;Cell Communication;Cell Culture Techniques;Cell Death;Cell Line;Cell Polarity;Cells;Cellular biology;Childhood;Cilia;Clarin-1;Complex;cost;Culture Media;deafness;design;Development;Diffuse;Discipline;Disease;disease model;effective therapy;Electrophysiology (science);Embryoid bodies;Engineering;Environment;experience;Exposure to;gene function;gene therapy;Generations;Genes;genetic analysis;genome editing;Harvest;human disease;Hydrogels;Hypoxia;improved;Incubated;induced pluripotent stem cell;interest;Investigation;Knowledge;Learning;Link;Liquid substance;Magnetism;Manuscripts;Measurement;Methods;Modeling;Molecular;Morphogenesis;mouse model;Muller's cell;Mutation;Neck;neural;Neural Retina;neurotrophic factor;novel;Nutrient;Nutrient availability;Optic vesicle;optical sensor;Organoids;Outcome;Oxygen;Oxygen Consumption;Partial Pressure;Pathogenicity;Pathway interactions;Phase;Phenotype;Photoreceptors;Pigment Epithelium;Preparation;Process;Production;protein transport;Proteins;Protocols documentation;Reproducibility;Research;Resources;Retina;Retinal Degeneration;Rodent Model;Role;RPGR gene;Side;Signaling Molecule;small molecule;Spottings;Stains;Starvation;Stem cell transplant;stem cells;Structure;Survival Rate;Synapses;Syndrome;Therapeutic;Therapeutic Studies;three dimensional structure;Tissues;USH1C gene;Usher Syndrome;Usher Syndrome Type 1;Vision

PROJECT_TITLE: Disease mechanism and therapies for retinal degeneration


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Patient Safety;Precision Medicine

PI_NAMEs: CUKRAS, CATHERINE  (contact)

PROJECT_TERMS: Affect;Blood specimen;Caring;Chloroquine;Clinical;clinical center;Congresses;Data;Development;DNA Sequence Alteration;Family;field study;Fundus;Genes;Genetic;genetic analysis;Genetic Screening;Genotype;Hydroxychloroquine;Individual;Knowledge;Medical;Mutation;Observational Study;Operative Surgical Procedures;ophthalmic examination;Ophthalmologist;Other Genetics;Outpatients;Participant;participant enrollment;Patients;personalized medicine;Pharmaceutical Preparations;Phenotype;Physical Examination;Publishing;Recording of previous events;recruit;Retina;retinal toxicity;Testing;Time;Toxic effect;United States National Institutes of Health;Visit;Visual;Visual Fields

PROJECT_TITLE: Genotype - phenotype Study of Patients with Plaquenil-induced Retinal Toxicity,


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TITLE: Organization and development of the S-cone system


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

PROJECT_TERMS: Affect;Age related macular degeneration;Blindness;Categories;Clinical;Clinical assessments;Clinical Trials;Dark Adaptation;Darkness;Data;design;Detection;Disease;Disease Progression;Elderly;Eye;functional outcomes;Fundus photography;Impairment;Investigation;Late-Onset Disorder;Measures;Mediating;Monitor;Neurodegenerative Disorders;Nonexudative age-related macular degeneration;novel;novel therapeutics;Outcome Measure;Participant;participant enrollment;Pathology;Patient Self-Report;Patients;Persons;Protocols documentation;retinal rods;Rod;Schedule;Severities;Severity of illness;Time;Vision;Vision Screening;Visual;Visual Acuity;Visual impairment

PROJECT_TITLE: Longitudinal Investigation of Dark Adaptation in Participants with AMD


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: KRAUZLIS, RICHARD  (contact)

PROJECT_TERMS: Age;Anatomy;Animal Model;Animals;Area;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Axon;Basal Ganglia;Behavior;Brain;Brain region;Cells;Cerebral cortex;cholinergic;Complement;Complex;Computer Models;Contralateral;Corpus striatum structure;Detection;Disease;Dopamine;Dorsal;Event;expectation;Face;Face Processing;Fiber;fovea centralis;frontal lobe;Genetic;Goals;Human;Image;in vivo;Individual;interest;Interneurons;Lateral Geniculate Body;Learning;Macaca;Methods;Midbrain structure;Modeling;Molecular Target;Monkeys;Motor;motor control;Mus;neuronal circuitry;Neurons;neurophysiology;nonhuman primate;novel;object recognition;operation;optogenetics;Output;Pathway interactions;Perception;Performance;Peripheral;Photometry;Phylogenetic Analysis;Play;Population;preference;Primates;Probability;Process;Property;Publishing;rapid detection;Recovery;Recovery of Function;recruit;response;Retina;Rewards;Rodent;Role;Route;Scientist;segregation;selective attention;Sensory;sensory cortex;Sensory Disorders;Signal Transduction;skills;Slice;somatosensory;Stimulus;Structure;superior colliculus Corpora quadrigemina;Synapses;System;Techniques;Testing;Thalamic structure;Therapeutic Intervention;Time;transmission process;virtual;Vision;Visual;Visual attention;visual control;Visual Cortex;Visual Fields;visual learning;visual motor;visual object processing;Visual Pathways;visual processing;Visual System;Work

PROJECT_TITLE: Visual Circuits


PI_NAMEs: KEENAN, TIARNAN  (contact)

PROJECT_TERMS: Age related macular degeneration;biobank;Biological Markers;Biological Specimen Banks;biomarker identification;Clinical Data;clinical database;Collection;Data Collection;Data Set;design;Diabetic Retinopathy;Disease;Enrollment;Experimental Models;Eye;Genetic;genetic variant;Health;minimal risk;novel;ocular imaging;Outcome Measure;Participant;Pathogenesis;Phenotype;prospective;Protocols documentation;Reporting;Research;Retina;Retinal Diseases;Sampling;Schedule;Specific qualifier value;Standardization;study population;Testing;treatment response;Visual Acuity

PROJECT_TITLE: NEI Intramural Biorepository for Retinal Diseases (12-EI-0042)


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TERMS: Adverse event;Affect;Age Years;Anti-Inflammatory Agents;bevacizumab;Blindness;cellular targeting;central retinal vein occlusion;Chronic;Clinical Research;Data;design;Dose;Effectiveness;Eligibility Determination;Exhibits;Extravasation;Eye;Fluorescein Angiography;Generations;histological studies;Human;improved;Inflammation;Inflammatory;inhibitor;Injections;Injury;Length;Letters;Liquid substance;macula;macular edema;Masks;Measures;Mediation;Microglia;migration;Minocycline;Multicenter Studies;Natural History;Neurons;Oral;Participant;Perimetry;Persons;Pharmaceutical Preparations;placebo group;Placebos;primary outcome;Process;Property;Randomized;response;Retina;retinal toxicity;Retinal Vein Occlusion;Safety;safety outcomes;secondary outcome;Severities;Site;Source;Structure;systemic toxicity;Testing;Tetracyclines;Thick;Time;Treatment Factor;Vascular Endothelial Growth Factors;vein occlusion;Visit;Visual Acuity;Withdrawal

PROJECT_TITLE: Eval. of Minocycline as a Microglia Inhibitor in Tx of CRVO and BRVO


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Hearing Loss;Neurosciences;Rare Diseases;Usher Syndrome

PI_NAMEs: ZEIN, WADIH  (contact)

PROJECT_TERMS: 10q;11p;11q;17q;Affect;Air;Audiology;Auditory;autosome;Blood specimen;Bone Conduction;caloric stimulation;Categories;CDH23 gene;chromosome 5q loss;Chromosomes;Cities;Classification;Clinical;college;computerized;deaf;Disease;disease natural history;DNA;ear muscle;early childhood;Electroretinography;Enrollment;Equilibrium;Evaluation;Eye Movements;Fluorescein Angiography;Fundus photography;Genes;genetic deafness;Genetic study;genetic testing;Genotype;hearing impairment;Inherited;Knowledge;Lens Opacities;Life;Link;macula;macular edema;middle ear;Molecular;Molecular Genetics;Mutation;MYO7A gene;Natural History;Nature;New York;Night Blindness;Noise;oculomotor;Optic Nerve;otoacoustic emission;Participant;participant enrollment;Patients;PCDH15 gene;Phenotype;Phenylephrine;Photography;Positioning Attribute;Procedures;Protocols documentation;Reflex action;Rehabilitation therapy;Reporting;Retina;Retinitis Pigmentosa;Severities;Site;Speech Intelligibility;speech recognition;Syndrome;Testing;tomography;tool;Tropicamide;Tympanometry;United States National Institutes of Health;Universities;USH1C gene;USH2A gene;Usher Syndrome;Usher Syndrome Type 1;Usher Syndrome Type 2;Vestibular dysfunction;Vestibular function;Vestibular Function Tests;vestibular system;Vision;Visit;Visual Acuity;Visual Fields;VLGR1 gene;WHRN gene

PROJECT_TITLE: Natural History and Genetic Studies of Usher Syndrome


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: QIAN, HAOHUA  (contact)

PROJECT_TERMS: adeno-associated viral vector;Anatomy;Animal Model;Animals;behavior test;Code;Darkness;Databases;early detection biomarkers;effectiveness evaluation;Electrophysiology (science);Evaluation;Fundus;Gene Expression;gene replacement therapy;Genes;Goals;Health;Human;Image;in vivo;inherited retinal degeneration;interest;intravitreal injection;Manuals;Methods;mouse model;Mus;novel;Optical Coherence Tomography;Patients;Pattern;restoration;Retina;retinal imaging;Severities;Signal Pathway;Signal Transduction;Subgroup;Techniques;Testing;therapeutic gene;Time;tool;Transgenic Organisms;Vision;Visual;visual performance

PROJECT_TITLE: Evaluation of Visual Function in Animal Models


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Address;Age;Biological Assay;Blood specimen;Cell Differentiation Induction;Cells;Cellular biology;Child;Clinic;Clinical;clinical outcome measures;Clinical Trials;cohort;Consent;Darkness;Data;Data Analyses;deep learning;Diagnostic Imaging;Disease;disease model;Disease Progression;DNA;Dose;efficacy testing;Electrophysiology (science);Electroretinography;Eligibility Determination;Enrollment;Evaluation;Eye;Family;FDA approved;Fibroblasts;Five-Year Plans;Flecks;follow-up;Formulation;functional outcomes;Future;Generations;genetic testing;Genotype;Goals;high-throughput drug screening;Image;In Vitro;induced pluripotent stem cell;Institutional Review Boards;Investigation;Measures;Medical;Medical Genetics;Medical Records;membrane-associated placental tissue protein 1;Metformin;Molecular;Monitor;Natural History;Neural Retina;novel;Nuclear;open label;ophthalmic examination;Optical Coherence Tomography;Oral cavity;Outcome;Outcome Measure;Outcome Study;Participant;participant enrollment;Pathogenesis;Patients;Perimetry;Pharmaceutical Preparations;Phase II Clinical Trials;Phenotype;Plasma;Population Study;primary outcome;Protocols documentation;Psychophysiology;Questionnaires;Recording of previous events;recruit;repository;Research;Research Personnel;Retina;Retinal Diseases;Safety;Sampling;Scanning;secondary outcome;Serum;Skin;skin biopsy;Standardization;Structure of retinal pigment epithelium;Techniques;Therapeutic;Thinness;Time;time use;Titrations;treatment trial;United States National Institutes of Health;Vision;Vision Tests;Visit

PROJECT_TITLE: Natural History of ABCA4-Related Retinopathies


PROJECT_TERMS: Affect;Area;Blindness;Ciliary Neurotrophic Factor;Degenerative Disorder;Devices;Disease;Enrollment;Eye;follow-up;Goals;Implant;implantable device;implantation;macula;Manuscripts;Measures;Multicenter Studies;Nerve Degeneration;Participant;Phase;Phase II Clinical Trials;phase II trial;Phase III Clinical Trials;Photoreceptors;Placebos;primary endpoint;Protocols documentation;Publications;Reporting;Retina;Safety;sham surgery;Site;Telangiectasis;Testing;United States National Institutes of Health;Visit

PROJECT_TITLE: Phase 2 Clinical Trial of Ciliary Neurotrophic Factor (CNTF) for Macular Telangiectasia Type 2 (MacTel) (14-EI-0078, 17-EI-0136)


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

PROJECT_TERMS: Adverse event;Affect;Animal Model;Antibiotics;Bilateral;Blindness;Categories;Cell Death;Cells;clinical trial enrollment;constriction;Contralateral;Cystoid Macular Edema;Development;Disease;Etiology;Eye;FDA approved;Genetic Diseases;glial activation;Immune;Inflammatory;Intervention;Label;Letters;macula;macular edema;Measurement;Measures;Microglia;Minocycline;neuroinflammation;neuroprotection;open label;Optical Coherence Tomography;Oral;Oral Administration;Outcome;Participant;Patients;Perimetry;Peripheral;Pharmaceutical Preparations;Phase I/II Clinical Trial;Pilot Projects;Process;Production;prospective;response;Retina;Retinitis Pigmentosa;Safety;Thick;Time;Vision;Visual Acuity;Visual Fields

PROJECT_TITLE: Pilot Study to Evaluate Oral Minocycline in the Treatment of Cystoid Macular Edema Associated with Retinitis Pigmentosa


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: TAM, JOHNNY  (contact)

PROJECT_TERMS: adaptive optics;Aging;Area;Artificial Intelligence;Cells;cellular imaging;Cellular Structures;Clinic;clinical application;clinical center;clinical imaging;Cloud Computing;Collaborations;Custom;Data;Data Science;Data Set;design;Detection;Development;Diagnosis;Disease;Disease Progression;Extramural Activities;Eye;Eye diseases;Female;Functional disorder;generative artificial intelligence;Goals;healthy volunteer;Human;human imaging;Image;Image Enhancement;imaging approach;Imaging Device;imaging modality;imaging platform;imaging program;Imaging technology;improved;instrumentation;Light;live cell imaging;male;Measures;Microscopic;National Eye Institute;National Institute of Biomedical Imaging and Bioengineering;Nature;Neurodegenerative Disorders;next generation;Noise;Onset of illness;Ophthalmoscopes;Optical Coherence Tomography;optical imaging;Optical Instrument;Optical Methods;Optics;Patients;Pilot Projects;programs;Research;Resolution;Retina;Retinal Diseases;retinal imaging;Role;Scanning;sex;Signal Transduction;Speed;Stream;Structure;Structure of retinal pigment epithelium;Techniques;Technology;Time;United States National Institutes of Health;Universities;Visualization

PROJECT_TITLE: Adaptive Optics Retinal Imaging


NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Affect;age effect;Age related macular degeneration;Aging;Autopsy;autosome;base;Basic Science;case control;Cell Death;Cells;Clinical;cohort;Collaborations;Complement;complement pathway;Complex;CRISPR/Cas technology;Data;Defect;Development;Dexamethasone;Diet;Disease;disease phenotype;Disease Progression;disease-causing mutation;DNA Methylation;DNA methylation profiling;drug candidate;drug discovery;Effectiveness;Environment;Environmental Risk Factor;epigenetic regulation;epigenome;Exhibits;exome;Family;Fluorescence;Functional disorder;Gene Expression;gene regulatory network;Genes;genetic association;Genetic Counseling;Genetic Determinism;Genetic study;Genetic Variation;Genome;genome sequencing;genome wide association study;Genotype;Glaucoma;Goals;Human;Immune;Immune response;induced pluripotent stem cell;Inherited;insight;Intervention;Knockout Mice;lead candidate;Leber's amaurosis;Literature;macula;Macular degeneration;Manuscripts;Metabolic Pathway;Methods;Methylation;Modality;Modeling;Molecular;mouse model;Mus;Mutation;Nerve Degeneration;novel;novel therapeutics;Organoids;Pathogenesis;Pathology;Pathway interactions;Patients;Phenotype;Photoreceptors;Phototransduction;Preparation;Promoter Regions;protein expression;Publishing;Quantitative Trait Loci;rare variant;Rattus;Reporter Genes;Reporting;Research;Reserpine;Retina;Retinal Degeneration;Retinal Diseases;Retinitis Pigmentosa;Rhodopsin;RNA Editing;RNA Splicing;Rod;Role;segregation;Services;Signal Pathway;Site;small molecule;Testing;Therapeutic;therapeutic candidate;therapeutic development;Therapeutic Intervention;TIMP3 gene;Trabecular meshwork structure;trait;transcriptome;transcriptome sequencing;Untranslated RNA;Variant;Visual impairment;whole genome;Work

PROJECT_TITLE: Mechanisms, modeling and therapies of retinal and macular neurodegeneration


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

PI_NAMEs: JEFFREY, BRETT  (contact)

PROJECT_TERMS: Age related macular degeneration;Amendment;Area;Australia;Cessation of life;Cladribine;Clinical;Clinical Trials;Collaborations;Color;Cone;Custom;Dark Adaptation;Darkness;Discrimination;Disease;Early Diagnosis;Enrollment;Family;FDA approved;Functional disorder;Fundus;healthy volunteer;instrument;Kinetics;late-onset retinal degeneration;Light;macula;Measures;Mediating;member;Methods;Modification;Monitor;Normal Range;novel;Outcome Measure;Participant;Patients;Pattern;Perimetry;Process;Protocols documentation;Psychophysics;Publishing;recruit;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;Rod;Schedule;Shapes;Stimulus;systems research;Telangiectasis;Testing;Vertebrate Photoreceptors;Visual Fields

PROJECT_TITLE: Rod and Cone Mediated Function in Retinal Disease


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: HURYN, LARYSSA  (contact)

PROJECT_TERMS: Affect;Anatomy;Ataxia;Atrophic;autosome;Blindness;CAG repeat;Case Series;Case Study;Characteristics;Clinical;clinical outcome measures;Clinical Trials;Code;cohort;comorbidity;Data Analyses;DNA;Enrollment;Fibroblasts;Future;Genes;Genetic Anticipation;Individual;information gathering;Life Style Modification;Molecular;Natural History;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;Participant;Patients;Plasma;Population;prospective;Quality of life;Reporting;repository;Retina;Retinal Degeneration;Sampling;Skin;Spinocerebellar Ataxias;Time;Type 7 Spinocerebellar Ataxia

PROJECT_TITLE: Natural History of Spinocerebellar Ataxia Type 7 (SCA7)


PROJECT_TERMS: Adverse event;Affect;Age related macular degeneration;Aging;Area;arm;Atrophic;Blindness;Cells;Choroidal Neovascularization;Cicatrix;Clinical;Development;Dose;Dryness;Etiology;Evaluation;Eye;Fundus;Fundus photography;geographic atrophy;Geographic Locations;human old age (65+);Image;Immune;Impairment;Inflammation;Inflammatory;luminance;macula;Macular degeneration;Measures;Microglia;Minocycline;neovascular;ocular surface;Oral;Participant;Patient Recruitments;Patients;Perimetry;Persons;Phase;phase 2 study;Photoreceptors;prevent;primary outcome;Process;prospective;rate of change;Reading;recruit;Retina;Retinal Degeneration;Running;Safety;safety outcomes;secondary outcome;Severities;Structure of retinal pigment epithelium;Study Subject;United States;Visit;Visual Acuity

PROJECT_TITLE: Evaluation of Oral Minocycline in Treating Geographic Atrophy Associated with Age-Related Macular Degeneration


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

PROJECT_TERMS: Adrenal Glands;Adverse event;Affect;aggressive therapy;angiogenesis;antagonist;Appearance;autosome;Benign;Blindness;Brain;Broad Ligament;Cell Line;cell type;Cyst;design;Disease;Electronics;eligible participant;Epididymis;experience;Exudate;Eye;Fibrosis;Fluorescein Angiography;Fundus photography;Hereditary Disease;Histopathology;Individual;intravitreal injection;Investigational Therapies;Kidney;Labyrinth;Letters;Malignant Neoplasms;Manuscripts;Measures;Mediator;open label;Operative Surgical Procedures;Optical Coherence Tomography;Outcome Measure;Outcome Study;Pancreas;Paper;Participant;PDGFA gene;Phase;phase 1 study;Phase I/II Trial;Platelet-Derived Growth Factor;primary outcome;Proliferating;prospective;Publications;Publishing;ranibizumab;Reporting;Retina;Role;Safety;secondary outcome;Spider nevus;Spinal Cord;standard care;study population;Testing;Traction;tumor;United States;Vascular Endothelial Growth Factors;Vascular Permeabilities;VEGFA gene;VHL protein;Vision;Visual Acuity;Von Hippel-Lindau Syndrome

PROJECT_TITLE: A Phase I/II Trial for Intravitreous Treatment of Severe Ocular von Hippel-Lindau Disease Using a Combination of the PDGF Antagonist E10030 and the VEGF Antagonist Ranibizumab (16-EI-0159)


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Human Genome;Microbiome;Precision Medicine

PI_NAMEs: CASPI, RACHEL R. (contact)

PROJECT_TERMS: active method;Adrenal Cortex Hormones;Affect;age related;Anatomy;Animal Model;Anterior;arm;Basic Science;biobank;Biological;Biological Assay;Blindness;Categories;Cells;Clinical;Clinical Markers;Clinical Research;clinical subtypes;Clinical Trials;cohort;commensal microbes;design;Diagnostic;Disease;Disease remission;Enrollment;epigenomics;Failure;Flare;Flow Cytometry;Gene Expression Profiling;Goals;gut dysbiosis;gut microbiome;gut microbiota;healthy volunteer;high dimensionality;high risk;Human;human disease;Immune;immune function;immune modulating agents;Immune system;Immunologics;improved;Individual;Inflammation;Inflammatory;innovation;Intermediate Uveitis;Intervention;Laboratories;Location;Manuscripts;Mediating;microbial;microbiome;Molecular;Molecular Immunology;Molecular Profiling;Panuveitis;Participant;Pathogenesis;patient oriented;patient subsets;Patients;Peripheral Blood Mononuclear Cell;personalized medicine;Pharmaceutical Preparations;Phenotype;Pilot Projects;Posterior Uveitis;Prediction of Response to Therapy;Preparation;Prognosis;prognosis biomarker;programs;prospective;Proteomics;Role;Sampling;single cell sequencing;standard of care;stool sample;systemic autoimmune disease;Techniques;Therapeutic;Tissues;transcriptome sequencing;transcriptomics;translational approach;Translational Research;Treatment Protocols;treatment responders;treatment response;Undifferentiated;unnecessary treatment;Uveitis;Vision

PROJECT_TITLE: Studies of Ocular inflammation: Clinical & Translational Research