NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Age;behavioral health;Biological;Black race;Buffers;Caregiver well-being;Child;Child Abuse and Neglect;Child Development;child protective service;Child Rearing;Child Welfare;Childhood;Clinical;Cognitive Therapy;Communication;Communities;community based participatory research;community engagement;community partners;Competence;contextual factors;coping;Coping Skills;Development;Developmental Process;Discrimination;Distal;Educational Curriculum;Environment;Ethnic Origin;evidence base;Evidence based treatment;experience;Exposure to;Face;Family;family support;Focus Groups;Future;health disparity;implementation facilitators;implementation science;improved;innovation;Institutional Racism;Intervention;Knowledge;Life Cycle Stages;life span;maltreatment;marginalization;Mental Health;Mental Health Services;Methods;next generation;novel strategies;Nuclear Family;Outcome;Pathogenicity;Personal Satisfaction;physical conditioning;Pilot Projects;Population;Population Intervention;post-traumatic stress;post-traumatic symptoms;Practical Robust Implementation and Sustainability Model;Pregnancy;Prevention;Procedures;psychologic;Psychopathology;Public Health;public health relevance;Race;racial discrimination;racial identity;racism;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;reduce symptoms;Research;Research Design;research study;Risk;Science;self esteem;skills;social health determinants;Socialization;stakeholder perspectives;Stress;Symptoms;System;Testing;Transact;Translational Research;Trauma;Youth

PROJECT_TITLE: Pilot study of buffering racial stress and trauma for youth exposed to maltreatment


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Drug Abuse (NIDA only);Emerging Infectious Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Substance Misuse;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: PHOENIX

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: INTER TRIBAL COUNCIL OF ARIZONA, INC.

ORG_STATE: AZ

PHR: Project Narrative The project will work toward reducing health disparities related to tick and mosquito vectors. Tribal members will direct vector and vector-borne pathogen surveillance and data management. Native American students engaged in community-based participatory research will receive studentships, improving research capacities and reducing distrust of research by Native American communities.

PI_NAMEs: GOUGE, DAWN HEATHER (contact)

PROJECT_TERMS: acaricide;Adherence;Aedes;American Indian community;Area;Arizona;Arthropod Vectors;Awareness;Bacterial Infections;California;Canis familiaris;Case Fatality Rates;Cessation of life;Collaborations;Collection;Committee Members;Communicable Diseases;Communities;community based participatory research;community based research;community college;community engagement;Community Outreach;community partners;Culicidae;data management;Dengue Virus;Disease;Disease Surveillance;Disease Vectors;distrust;Education;Enrollment;Environmental Health;Environmental Protection;Epidemic;Equipment;Event;experience;Faculty;Financial Support;Funding;Future;Grant;Health Benefit;health disparity;Health Personnel;high risk;Home;human disease;improved;indexing;indigenous community;Infrastructure;Institution;intertribal;Investments;Knowledge;Laboratories;land use;learning outcome;Measurable;Measures;Medical;Medical Entomology;member;Mentors;Methods;Mexico;Modification;Monitor;Native American community;Native American population;Native American Research Center for Health;Native Americans;Native-Born;North America;outreach;pathogen;Persons;Pharmaceutical Preparations;Population;portability;preservation;Prevalence;Procedures;Process;Protocols documentation;Public Health;Readiness;Reduce health disparities;Research;Research Personnel;Research Project Grants;resilience;Rhipicephalus sanguineus;Rickettsia rickettsii;Risk;risk mitigation;risk perception;risk prediction;Risk Reduction;Rocky Mountain Spotted Fever;Safety;Sampling;Services;student participation;Students;Testing;Tick Control;Tick-Borne Diseases;Ticks;Time;Training;tribal community;Tribal Council;tribal health;tribal lands;tribal leader;tribal member;Tribes;Universities;vector;vector control;vector mosquito;vector-borne pathogen;Vector-transmitted infectious disease;West Nile viral infection;Work;Yellow Fever;Zika Virus;Zoonoses

PROJECT_TITLE: UA Project: Advancing Vector-borne Disease Surveillance in American Indian Communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-N]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Substance Misuse

PHR: NARCH XII Capacity Building Project: Building Our Tribes’ Capacity to Initiate Community-Based  Research   Project Narrative  Tribal research sovereignty will not be realized until Tribes are self-empowered to fully manage the research  process ranging from problem identification to implementation, analysis, and dissemination. Tribally-initiated  projects are more likely to address the structural causes of disparities and Tribal solutions are more likely to be  sustained within the community. The ITCA Capacity Building project aims to provide Tribe-specific and  culturally-relevant mentorship to support Tribal projects as they are conceived within the Tribal community  through mentorship and technical assistance of the American Indian Research Center for Health (AIRCH) and  collaborative partners with expertise in Tribal research.

PI_NAMEs: LANE, TRAVIS  (contact)

PROJECT_TERMS: Address;American Indians;Area;Arizona;authority;Award;Collaborations;Communities;community based participatory research;community based research;Competence;Decision Making;Disparity;empowerment;Exercise;experience;Feedback;Fostering;Funding;Funding Agency;Grant;Health;Infrastructure;innovation;intertribal;Mentors;Mentorship;Mission;National Institute of General Medical Sciences;Native American Research Center for Health;Process;Qualifying;Readiness;Recording of previous events;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Proposals;research study;Resources;Role;Training;tribal community;Tribal Council;tribal member;tribal Nation;Tribes;unethical;Universities;Writing

PROJECT_TITLE: ITCA NARCH 12 Capacity Building Core


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The goals of this R50 project are to support ongoing NCI-funded research projects to 1) to use immunogenomic analyses of spatially mapped brain tumor samples spanning maximal tumor volume to discover tumor-wide neoantigens that elicit immune responses, and which can be used to develop a platform for personalized immunotherapies for brain tumor patients; and 2) to understand the mechanism by which tumor cells with the TERT promoter mutation acquire the ability to proliferate indefinitely (cellular immortality) in order to develop targeted therapies for the large number of human tumors with this mutation.

PI_NAMEs: HONG, CHIBO  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: 3-Dimensional;Address;Adult;Antigen Presentation;Biotechnology;Brain Mapping;Brain Neoplasms;Cell division;Cells;chemotherapy;Clinical;Collaborations;Data;Ensure;epigenomics;Evolution;Failure;Funding;Genes;Genomics;Glioblastoma;Glioma;Goals;Growth;Human;Immune response;immunogenic;Immunogenomics;Immunosuppression;in vivo;Individual;Infrastructure;Laboratory Research;life span;Malignant - descriptor;Malignant Neoplasms;Maps;member;method development;mutant;Mutation;neoantigens;neoplastic cell;Neurosurgeon;new therapeutic target;novel therapeutics;Patients;personalized immunotherapy;Pharmaceutical Preparations;Play;Proliferating;promoter;Property;recruit;Regulation;Request for Applications;Research;Research Project Grants;RNA-Directed DNA Polymerase;Role;sample collection;Sampling;Scientific Advances and Accomplishments;small molecule;T cell receptor repertoire sequencing;T-Cell Receptor;targeted treatment;technology development;Telomerase;Telomere Shortening;Therapeutic;Training;transcription factor;transcriptomics;Translating;translational goal;tumor;tumor heterogeneity;Tumor Volume;Wages

PROJECT_TITLE: The Immortality and Evolution of Adult Brain Tumors


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

PI_NAMEs: SOLOMON, TESHIA G. ARAMBULA (contact)

PROJECT_TERMS: Alaska Native;Alaska Native population;American Indian community;American Indian Population;American Indians;Arizona;Asian population;Attention;Award;Black Populations;Cardiovascular Diseases;career;citizen science;Collaborations;college;Communities;Development;Diabetes Mellitus;disparities in morbidity;Drops;Education;Educational Curriculum;empowerment;Ethnic Origin;experience;Faculty;Family;Fright;Future;Grant;Health;health disparity;health equity;health organization;health science research;Health Sciences;Health Status;high school;High School Student;Hispanic Populations;improved;Income;Indigenous;Institute of Medicine (U.S.);interest;intertribal;Knowledge;Leadership;literacy;Malignant Neoplasms;matriculation;Mental Health;minority health professional;mortality;Native American Research Center for Health;Pascua Yaqui;Personal Satisfaction;physical conditioning;prevent;programs;Race;racial population;Recommendation;recruit;Reduce health disparities;Research;Research Personnel;Reservations;response;role model;Schools;Science;science education;STEM field;structural determinants;Structure;Students;success;Suicide;teacher;Testing;Training;tribal community;Tribal Council;tribal health;tribal leader;Tribes;United States National Institutes of Health;Universities;university student;Youth

PROJECT_TITLE: UA Student Dev: Rising Stars Program for AI/AN Students at UArizona


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Immunization;Immunotherapy;Nanotechnology;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse;Vaccine Related

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Vaccines are emerging as novel strategies for treating OUD and preventing fatal overdose. To accelerate the clinical utility of conjugate vaccines, we are developing next-generation anti-opioid vaccines using cutting-edge nanotechnology-based platforms. Exploiting the modular nature of nanoparticle platforms, this proposal focuses on characterizing the molecular and cellular mechanisms underlying vaccine efficacy to provide a blueprint for vaccine development and rational design of most effective formulation to a given antigen.

PI_NAMEs: HAMID, FATIMA ALAMIN AWAD ALKAREEM (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: abuse liability;Acceleration;Active Immunization;adaptive immune response;adaptive immunity;addiction;Address;Adjuvant;Affect;Affinity;Agonist;antagonist;Antibodies;Antibody Response;Antibody titer measurement;Antigen-Presenting Cells;Antigens;antinociception;B cell differentiation;B Cell Proliferation;B-Cell Activation;B-Lymphocytes;Biodistribution;Biological Availability;Bradycardia;Brain;career;CD4 Positive T Lymphocytes;Cell Cycle Kinetics;Cells;Clinical;Clinical Trials;Communication;Communities;Complex;Conjugate Vaccines;COVID-19 vaccine;Data;Dendritic Cells;design;Development;draining lymph node;Drug Targeting;Economic Burden;Ensure;Epidemic;FDA approved;Fellowship;Fentanyl;Flow Cytometry;fluorescence imaging;Formulation;Funding;Future;Glycolates;Haptens;Helper-Inducer T-Lymphocyte;Hybrids;immune activation;immunogenicity;Immunoglobulin G;Immunoglobulins;Immunohistochemistry;Immunology;Immunomodulators;improved;In Vitro;in vivo;in vivo evaluation;in vivo imaging;Individual;individual variation;Injections;Innate Immune Response;Kinetics;Lipid A;lipid nanoparticle;Lipids;Liposomes;lymph nodes;Macrophage;Measures;Memory;Memory B-Lymphocyte;Mentors;Mentorship;Methods;migration;Modeling;Molecular;Monitor;Motor Activity;multidisciplinary;Mus;nanocarrier;nanoformulation;nanoparticle;Nanotechnology;nanovaccine;National Institute of Drug Abuse;Natural Immunity;Nature;next generation;Nicotine;nicotine vaccine;novel;novel strategies;novel vaccines;Opioid;Opioid agonist;opioid use;opioid use disorder;Overdose;overdose death;Oxycodone;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Phase I Clinical Trials;Plasma;Plasma Cells;poly(lactic acid);polyclonal antibody;Polymers;Positioning Attribute;Pre-Clinical Model;Preclinical Testing;prevent;Process;prophylactic;Public Health;public health emergency;Quantitative Reverse Transcriptase PCR;rational design;recruit;Research;resiquimod;response;Rewards;Safety;Scientist;secondary lymphoid organ;Self Administration;Serum;side effect;Site;skills;Spleen;Structure of germinal center of lymph node;Substance abuse problem;Substance Use Disorder;success;targeted delivery;Testing;therapeutically effective;Time;time use;TLR4 gene;TLR7 gene;trafficking;Training;Translational Research;Translations;Vaccinated;Vaccination;vaccine candidate;vaccine delivery;Vaccine Design;vaccine development;vaccine efficacy;vaccine evaluation;vaccine formulation;vaccine platform;Vaccines;vaccinology;Ventilatory Depression

PROJECT_TITLE: Nanotechnology-based platform for the development of next-generation vaccines against opioid use disorder (OUD)


ADMINISTERING_IC: HD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Prevention

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PI_NAMEs: CERULLI, CATHERINE  (contact)

PROJECT_TITLE: Dissemination and Outreach Core


ADMINISTERING_IC: HG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The Stanford Genome Training Program trains PhD students and postdoctoral fellows to advance to productive technical and high-level leadership positions in the biomedical sciences, in academia and in the private sector. Specifically, we train the next generation of scientists in the field of genomics and related areas, which has become a centerpiece in understanding basic biology as well as disease diagnosis and prevention, due to tremendous technical advances and a confluence of computer science with biomedicine. Many of those advances were catalyzed and driven by our former trainees and those of similar institutions.

PI_NAMEs: SNYDER, MICHAEL P. (contact)

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TITLE: Institutional Training Grant in Genome Science


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_DEPT: NEUROLOGY

PHR: Project Narrative Diffuse midline glioma (DMG) and recurrent malignant brain tumors represent a high unmet need with essentially no long-term survivors. This project includes a phase 0/1 clinical trial assessing for the first time the mitochondrial targeting agent ONC206 in children with newly diagnosed and recurrent disease, alone and in combination with radiotherapy. For each trial participant we will collect tumor tissue, blood and CSF for pharmacokinetic, pharmacodynamic and genomic profiling with the hypothesis that ONC206 is safe, crosses the blood brain and blood tumor barrier, and targets mitochondrial ClpP protein.

PI_NAMEs: MUELLER, SABINE  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Adult;Apoptosis;arm;biological adaptation to stress;Biological Assay;Biological Markers;Biological Models;Biopsy;Blood;Blood - brain barrier anatomy;blood-brain barrier penetration;blood-brain tumor barrier;Brain;Brain Neoplasms;Cell Survival;Cells;Child;Childhood;Childhood Brain Neoplasm;circulating DNA;Clinical;Clinical Data;clinical efficacy;clinical predictors;cohort;Correlative Study;CRISPR/Cas technology;Data;design;Diagnosis;diffuse midline glioma;Disease Marker;Dopamine D2 Receptor;Dose;Drug Kinetics;Enrollment;Fees;first-in-human;Future;Genetic Transcription;genomic data;genomic profiling;H3 K27M mutation;health related quality of life;Human;In Vitro;in vivo;in vivo Model;irradiation;Knock-out;Lead;Location;Long-Term Survivors;Malignant neoplasm of brain;Medulloblastoma;metabolomics;misfolded protein;Mitochondria;Mitochondrial DNA;Mitochondrial Proteins;Modeling;Molecular;molecular subtypes;mouse model;neuro-oncology;Neuroanatomy;Newly Diagnosed;Newly Diagnosed Disease;novel;novel therapeutics;Operative Surgical Procedures;Oral;Outcome;Outcome Measure;Participant;Patient Outcomes Assessments;patient population;Patients;pediatric patients;Penetrance;Penetration;Peptide Hydrolases;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phase 0/1 Clinical Trial;Phase 0/1 Trial;phase 1 study;Phase I/II Clinical Trial;Play;Pontine structure;Population;potential biomarker;pre-clinical;predictive marker;Prognosis;protein expression;Proteins;Quality Control;Quality of Life Assessment;Radiation;radiation effect;Radiation therapy;radiological imaging;Recommendation;Recurrence;Recurrent disease;Regional Anatomy;Relapse;response;response biomarker;Role;Safety;safety assessment;safety testing;Sample Size;Serine Protease;Serum;standard of care;Survival Rate;synergism;targeted agent;Testing;Thalamic structure;Time;TNFRSF10B gene;TNFSF10 gene;Toxic effect;transcription factor CHOP;treatment response;tumor;tumor DNA;Tumor Tissue;Up-Regulation;Vertebral column;young adult

PROJECT_TITLE: Phase 0/1 trial of ONC206 - a novel imipridone for children with diffuse midline gliomas and recurrent malignant brain tumors

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Hematology;Infectious Diseases;Lung;Rare Diseases;Sepsis

ORG_CITY: Nashville

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Plasma cell-free hemoglobin (CFH) is increased in sepsis patients and damages the endothelial glycocalyx, a regulator of vascular permeability, but the mechanisms that underlie CFH-mediated glycocalyx injury remain unclear. This proposal will determine the molecular processes through which CFH promotes degradation of the endothelial glycocalyx. The insights gained will aid in the identification of specific targets to guide the development of improved treatments for patients with sepsis.

PI_NAMEs: BOGART, AVERY MAY (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Affect;Automobile Driving;Biological;Blood Vessels;career;Cause of Death;Cells;Cessation of life;Circulation;Clinical;Communication;Complex;cost;Critical Illness;Critical Thinking;Development;endothelial dysfunction;Endothelium;Enzymes;Erythrocytes;Experimental Designs;experimental study;extracellular;Functional disorder;Future;Genetic Transcription;Glycocalyx;Glycoproteins;Hemoglobin;heparanase;Human;Immune response;Impairment;improved;Infection;inflammatory milieu;Injury;insight;Investigation;knockout animal;Life;Link;Lung;lung injury;lung microvascular endothelial cells;Maintenance;Mediating;Mediator;Messenger RNA;Methods;Microvascular Permeability;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;mouse model;Mus;novel strategies;Organ;organ injury;Outcome;overexpression;Oxidants;oxidation;Oxidation-Reduction;Pathogenesis;Pathway interactions;Patients;Permeability;Persons;Physicians;Plasma Cells;polymicrobial sepsis;Problem Solving;Process;Production;Proteoglycan;Public Health;Reactive Oxygen Species;Research Personnel;Role;Scientist;Sepsis;septic;septic patients;Severities;skills;success;Superoxide Dismutase;Superoxides;syndecan;Testing;therapeutic development;Tissues;Training;transcription factor;Up-Regulation;Vascular Permeabilities

PROJECT_TITLE: Mechanisms of Cell-Free Hemoglobin-Mediated Injury to the Pulmonary Endothelial Glycocalyx in Sepsis


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: SWARTHMORE

ORG_DEPT: BIOLOGY

ORG_NAME: SWARTHMORE COLLEGE

ORG_STATE: PA

PHR: Project Narrative Neural signaling is a key regulator of cardiac proliferation, and disrupted neuron to heart signaling is implicated in cardiac disorders. I propose to illuminate the role of neural signaling during cardiac development by focusing on the role of a conserved neuropeptide known to be implicated in cardiac disease. This proposal will reveal fundamental mechanisms of heart development and result in a better understanding of cardiomyocyte proliferation and the functions of neuropeptides during development.

PI_NAMEs: GRUNER, HANNAH  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Adult;Affect;Anatomy;biomarker identification;Birth;Brain;Cardiac;Cardiac Myocytes;cardiogenesis;career;Catecholamines;Cause of Death;Cell Count;Cell Proliferation;cell type;Cells;Central Nervous System;Chordata;congenital heart abnormality;Data;Development;Embryo;Embryonic Development;Family;follow-up;Goals;Growth;Growth Factor;Heart;Heart Arrest;heart cell;Heart Diseases;heart innervation;Heart Rate;Human;Institution;Literature;mature animal;Mediating;Modeling;Morphology;Mus;Myocardial;Nerve;nerve supply;neural;neuromechanism;Neurons;Neuropeptides;Neurophysiology - biologic function;neurotransmission;Newborn Infant;novel;Outcome;Parasympathetic Nervous System;pericardial sac;postmitotic;postnatal;prevent;Process;Proliferating;Regulation;Reiterated Genes;release factor;Research;Role;Signal Transduction;single-cell RNA sequencing;Sister;Substance P;Sympathetic Nervous System;Tachykinin;Tachykinin Receptor;Testing;Time;Tube;undergraduate student;United States;Urochordata;Vertebrates

PROJECT_TITLE: Revealing the mechanisms of neural-mediated cardiac proliferation in Ciona robusta


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative We study the mTORC1 pathway, which is one of the most commonly dysregulated pathways in many cancers with low survival rates. Although inhibiting the key player mTORC1 has decreased tumor size in several models of cancer, our understanding of how different pools of mTORC1 contribute to cancer is limited. Our proposed study should lead to a better understanding of tumor growth and drug resistance in cancer.

PI_NAMEs: SAHAN, AYSE ZISAN (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: 3-Phosphoinositide Dependent Protein Kinase-1;Affect;Amino Acids;Apoptosis;Autophagocytosis;Biochemical;Biological Assay;Biosensor;Cancer Model;cell growth;Cell Line;Cell Nucleus;Cell Proliferation;Cell Survival;Cells;Cessation of life;Complex;cytokine;Cytosol;Data;differential expression;Disease;DNA Sequence Alteration;Drug resistance;drug sensitivity;Enzyme-Linked Immunosorbent Assay;Enzymes;Epidermal Growth Factor;experimental study;Fluorescence Resonance Energy Transfer;FRAP1 gene;Genes;Genetic Transcription;Growth;Growth Factor;Growth Inhibitors;In Vitro;in vivo;Inflammatory;inhibitor;Location;Lysosomes;Malignant Epithelial Cell;Malignant Neoplasms;Metabolism;Monitor;mouth squamous cell carcinoma;Mus;Nuclear;Nutrient;Pathway interactions;peroxisome;Phosphatidylinositols;phosphoproteomics;Phosphotransferases;Play;Proliferating;Proteins;Reactive Oxygen Species;Regulation;Reporter;Reporting;Research;Resistance;Role;Signal Pathway;Signal Transduction;Specificity;Survival Rate;Testing;tool;transcription factor;Transcriptional Regulation;transcriptome sequencing;Translations;tumor;tumor growth;tumor xenograft;Work;Xenograft Model

PROJECT_TITLE: Spatial regulation of mechanistic target of rapamycin complex 1 (mTORC1) and its role in oral squamous cell carcinoma

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_CITY: AUGUSTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: The limited fundamental understanding of cellular and molecular mechanisms underlying complex behaviors poses a major barrier for development of effective clinical applications to treat mental disorders. If successful, our research will significantly advance our fundamental understanding of epigenetic regulation of neuronal circuits controlling stress responses, and ultimately help pave the way for improving mental health in humans.

PI_NAMEs: JIAO, KAI ;POZZO-MILLER, LUCAS D;WANG, QIN  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Adult;Affect;Anterior;Anxiety;anxiety reduction;anxiety-related behavior;Axon;base;Behavior;Behavioral;behavioral response;Binding Sites;biological adaptation to stress;Brain;Cell Nucleus;CHD7 gene;ChIP-seq;Chromatin;Chromatin Remodeling Factor;cingulate cortex;clinical application;Complex;Data;Development;Embryo;emotional behavior;environmental stressor;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;excitatory neuron;Excitatory Synapse;experience;Exposure to;Female;Gene Expression;Gene Expression Regulation;gene network;Genetic Transcription;Goals;GTP-Binding Proteins;Human;improved;Individual;Knowledge;male;Maps;Medial;Mental disorders;Mental Health;Molecular;Molecular Profiling;Moods;multiple omics;Mus;neurodevelopment;neuronal circuitry;Neurons;neurophysiology;novel;Nuclear;Pathway interactions;Play;postmitotic;Prefrontal Cortex;Process;Property;Regulation;Research;response;Rodent;Role;Sampling;sexual dimorphism;Signal Transduction;Signaling Molecule;Signaling Protein;Stress;Structure of terminal stria nuclei of preoptic region;Synapses;Testing;transcriptome;Wild Type Mouse

PROJECT_TITLE: The Role of CHD7 in ACC neurons

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: OMAHA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE This project will investigate a novel mechanism of the YAP signaling activation facilitated by the PR55α-regulated PP2A and define the contribution of this cascade to pancreatic cancer (PC) development and progression driven by oncogenic Kras and loss of p53 tumor suppressor. The project will use a multidisciplinary approach, including in vitro cell-based models of PC progression, clinical specimens of primary/metastatic PC, and spontaneous mouse models of PC, to comprehensively delineate this novel PC-promoting mechanism based on the PR55α/YAP axis. Successful completion of the proposed project not only will improve our understanding of the role of PP2A in cancer but also will contribute to identifying novel therapeutic targets for improving the treatment of PC and possibly other Kras-driving malignancies.

PI_NAMEs: YAN, YING  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Anchorage-Independent Growth;Automobile Driving;Black race;Cancer Control;Cancer Etiology;cancer initiation;Catalytic Domain;Cells;Cessation of life;Clinical;Complex;conditional knockout;Critical Pathways;CUL1 gene;Cytoplasm;Data;defined contribution;Development;Disease;effective therapy;extend lifespan;F-Box Proteins;Family;Genes;Holoenzymes;Human;improved;In Vitro;innovation;interdisciplinary approach;knock-down;Knockout Mice;Knowledge acquisition;KPC model;KRAS oncogenesis;KRASG12D;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant phenotype;MAP Kinase Gene;Mediating;mouse model;Mutation;Neoplasm Metastasis;new therapeutic target;novel;Oncogenic;Pancreas;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;Pathogenesis;Pathway interactions;Patients;Pattern;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;PI3K/AKT;Play;Protein Kinase;Protein phosphatase;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;Regulation;Research;Retinal blind spot;Role;scaffold;Seminal;Signal Transduction;Source;Specimen;Substrate Specificity;support network;Survival Rate;targeted treatment;Testing;Tissues;TP53 gene;tumor progression;Tumor Suppression;tumorigenesis;Tumorigenicity;ubiquitin-protein ligase;Work

PROJECT_TITLE: PR55-alpha controlled PP2A in the regulation of the Hippo/YAP pathway

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Heart Disease;Hypertension;Infectious Diseases;Prevention

ORG_CITY: GABORONE

ORG_COUNTRY: BOTSWANA

ORG_FIPS: BC

ORG_NAME: UNIVERSITY OF BOTSWANA

PHR: Hypertension is one of the leading contributors of excess risk of heart attacks and strokes among the 36 million people living with HIV (PLWHIV) globally. The hypertension care cascade among PLWHIV has major deficits when compared to the HIV care cascade of 90:90:90. Our proposed study, to be conducted Botswana, will leverage a successful national ART program and infrastructure of a recently completed CDC/NIH funded HIV prevention trial to first develop an implementation strategy, and then use the new implementation strategy to conduct a type 2 hybrid multi-component cluster randomized trial to optimize evidence based implementation (EBI) uptake and improvement in the hypertension cascade among adults with dual diagnosis of HIV and Hypertension.

PI_NAMEs: GAOLATHE, TENDANI ;JAFFAR, SHABBAR  ;MOSEPELE, MOSEPELE  (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Address;Adoption;Adult;AIDS prevention;Anti-Hypertensive Agents;Attitude;Awareness;Blood Pressure;blood pressure control;Botswana;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Caring;Certification;Chronic Kidney Failure;Clinic;clinic ready;Cluster randomized trial;Communities;Consolidated Framework for Implementation Research;contextual factors;Continuity of Patient Care;Data;design;Development;Diabetes Mellitus;Diagnosis;Documentation;Drug Prescriptions;dual diagnosis;Effectiveness;effectiveness/implementation hybrid;Electronic Health Record;evidence base;Evidence based intervention;Funding;Funding Mechanisms;Guidelines;Health Personnel;Healthcare;HIV;HIV diagnosis;HIV prevention trial;hybrid type 2 design;Hybrids;Hypertension;hypertension control;hypertensive;implementation evaluation;implementation framework;implementation intervention;implementation measures;implementation outcomes;implementation research;implementation strategy;improved;Incidence;Infrastructure;Intervention;Interview;Knowledge;low and middle-income countries;Maintenance;Methods;multi-component intervention;Myocardial Infarction;operation;patient health information;Patients;Perception;peri-urban;Persons;Pharmaceutical Preparations;pilot test;Polypharmacy;Population;Prevention;Prevention Measures;programs;Provider;Quality of Care;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Design;Risk;Rural;Services;Site;social stigma;Stroke;success;Surveys;Testing;therapy design;Training;United States National Institutes of Health;uptake;Viral

PROJECT_TITLE: Integrating Hypertension and Cardiovascular Disease Care into Existing HIV Service Package in Botswana (InterCARE)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Heart Disease;Hypertension;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Hypertension remains a major public health issue in the United States and contributes to the development of cardiovascular diseases (CVD) and Alzheimer’s disease and related dementias (ADRD). Women older than 60 are at a particularly greater risk for the development of hypertension yet have a proportionally lower rate of blood pressure control, drastically increasing the likelihood for complications related to CVD and ADRD. Accordingly, the proposed work will investigate the impact of a home-based, lower leg heat therapy on blood pressure control in older, hypertensive women, while simultaneously assessing the autonomic cardiovascular mechanisms related to blood pressure regulation and their impact on cerebrovascular function and cognitive health.

PI_NAMEs: AKINS, JOHN DAVID (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Adherence;Alzheimer's disease related dementia;American Heart Association;awake;Bathing;bench to bedside;Biological Assay;Biological Markers;Blood;Blood flow;Blood Pressure;blood pressure control;blood pressure reduction;blood pressure regulation;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular Physiology;Cardiovascular system;Caring;cerebral autoregulation;cerebral hemodynamics;cerebrovascular;cerebrovascular health;Cerebrum;Chronic;Clinical;clinically relevant;Cognition;Cognitive;cognitive function;Combination Drug Therapy;Control Groups;Development;Disease Progression;Doctor of Philosophy;Echocardiography;Epidemiology;Episodic memory;executive function;Exhibits;experience;extracellular;Extramural Activities;Funding;Goals;group intervention;Guidelines;Health;Health Benefit;heart function;Heat shock proteins;Heating;Home;Homeostasis;Hour;Hypertension;hypertensive;Immersion;improved;indexing;Interdisciplinary Study;Intervention;Knee;Learning Skill;Leg;Life Style Modification;Measures;middle cerebral artery;Modeling;Morbidity - disease rate;mortality;Muscle;National Research Service Awards;Nerve;neural;neuroregulation;Nonpharmacologic Therapy;older women;Perfusion;Peripheral Resistance;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;physiologic stressor;Physiological;Physiological Adaptation;Population;Prevalence;primary outcome;processing speed;protein expression;Public Health;Qi;Recommendation;Regimen;Research;Research Personnel;response;Rest;Risk;Scientist;Short-Term Memory;Signal Transduction;standard care;success;Systemic blood pressure;Technical Expertise;Techniques;Therapeutic heat application;Therapeutic Intervention;tool;Training;Transcranial Doppler Ultrasonography;Translating;ultrasound;United States;United States National Institutes of Health;Update;Water;Woman;Work

PROJECT_TITLE: Lower Leg Heat Therapy in Older, Hypertensive Women to Improve Blood Pressure and Cognition


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The proposed project will investigate the role of contractile pericyte KATP hyperactivity in a well- established genetic mouse model of cerebral small vessel disease (SVD). The results from this project will provide mechanistic insights in the field involving pericyte participation during cerebral blood flow regulation. Furthermore, the proposed experiments will help to introduce new therapeutic targets focusing on early disease manifestations as SVDs currently have no cure and limited treatment options.

PI_NAMEs: JEFFREY, DANIELLE A (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 3-Dimensional;Acute;Agonist;antagonist;Arterial Disorder;Arteries;arteriole;autosome;Blood capillaries;Blood Vessels;Brain;brain pericytes;Capillary Endothelial Cell;cell type;Cells;Cephalic;Cerebral small vessel disease;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrum;Chronic;comparison control;Complex;Computer software;Data;Dementia;Deposition;Diameter;Disease;Distal;DTR gene;electrical property;Endothelial Cells;Epidermal Growth Factor Receptor;experimental study;Exposure to;extracellular;Extracellular Domain;Functional disorder;Genetic;genetic approach;Glyburide;Goals;Hour;Hyperactivity;Image;Immunohistochemistry;Impairment;in vivo;Induced Mutation;insight;Ischemic Stroke;Kinetics;knock-down;Ligands;Link;Literature;Location;Matrix Metalloproteinase Inhibitor;Measures;Membrane Potentials;Metabolic;Metabolic Diseases;Microcirculation;Microvascular Dysfunction;Modality;Modeling;Morphology;mouse model;Mus;mutant;Mutation;Nature;Neurons;neurovascular;neurovascular coupling;new therapeutic target;NOTCH3 gene;novel;Nutrient;Paper;parenchymal arterioles;patch clamp;Patients;Perfusion;Pericytes;Physiological;Pinacidil;Population;Potassium;Preparation;Production;Property;Proteins;Publishing;Reagent;receptor;Receptor Aggregation;Receptor Inhibition;Receptor Signaling;Regulation;Relaxation;Reporting;response;Role;Sentinel;Signal Transduction;Smooth Muscle Myocytes;Subcortical Infarctions;Subcortical Leukoencephalopathy;Syndrome;Techniques;Testing;Thinness;TIMP3 gene;Training;two-photon;uK-ATP-1 potassium channel;Vascular Dementia;Vascular Smooth Muscle;Vasodilation

PROJECT_TITLE: Pericyte KATP channel hyperactivity in cerebral small vessel disease


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE. This study challenges the current explanation for ERV-triggered sterility by exploring a previously uncharacterized mechanism centered on immune response activation. On a greater scale, these findings may provide insight into areas of human health where ERVs may be active, such as in instances of aging and cancer as well as at specific stages of development. Despite making up 8% of the human genome, much is still to be learned about how ERVs function and impact human health.

PI_NAMEs: STARK, KARA MICHELLE (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Affect;Aging;Apoptosis;Area;Autophagocytosis;Behavior;Binding;Biological Assay;Biological Metamorphosis;Cell Death;Cell Nucleus;Cell Survival;Cells;ChIP-seq;Couples;Cyst;Data;defense response;derepression;Development;DNA;DNA Damage;Drosophila genus;egg;Egg Preservation;Endogenous Retroviruses;Epigenetic Process;experimental study;feeding;Fertility;fly;Genes;genetic information;Genome;genomic locus;Genomics;Germ Cells;Germ Lines;Health;Human;Human Genome;Hyperactivity;Immune;immune activation;Immune response;Immune system;Immunosuppression;In Situ Nick-End Labeling;Infertility;insight;Invaded;Learning;LysoTracker;Malignant Neoplasms;Messenger RNA;migration;Modeling;Natural Immunity;novel;Nuclear;Nucleic Acids;offspring;Oocytes;Parents;Pathway interactions;Phenotype;piRNA;Play;Production;Proteins;Repression;Research;Retrotransposon;Reverse Transcription;RNA immunoprecipitation sequencing;Role;Severities;Signal Transduction;Signaling Molecule;Sterility;Structure;success;Testing;Tissues;transcription factor;transmission process;Travel;viral detection;Virus-like particle

PROJECT_TITLE: Examining the role of immune activation in transposon-triggered sterility.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-L(20)L]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Nutrition;Pediatric

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Narrative There is an urgent need to reduce the high prevalence and unequal distribution of weight-related problems, including obesity, poor dietary intake, inadequate physical activity, body dissatisfaction, and disordered eating behaviors. It is essential to train the next generation of scientists in how to conduct innovative and impactful research to ensure positive weight-related health among youth and families from diverse communities. There is a clear need for the proposed training program, which will utilize a health equity lens to address a broad spectrum of weight-related problems across critical periods of the life course and ensure that future scientists are trained in both observational and intervention research and in translating research into action.

PI_NAMEs: NEUMARK-SZTAINER, DIANNE R (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TITLE: Research on Eating and Activity for Community Health (REACH): An Applied Epidemiology Training Program to Improve Weight-Related Health in Youth and Families from Diverse Communities

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The retina is a highly organized tissue specialized for receiving and processing external stimuli from the visual scene. Efforts to treat retinopathy through regenerative procedures have been largely limited due to a lack of precise understanding about how retina formation is regulated during embryonic development. Here, I propose to combine novel experimental and computational approaches to comprehensively determine the cell fate decision programs that drive regular patterning during retina development.

PI_NAMEs: TRAN, MARTIN  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Adult;Bar Codes;Biological;Biology;Birth Order;Blindness;Brain;career;Cell Communication;Cell division;Cell Lineage;cell type;Cells;Collaborations;Core Facility;Data Analyses;Data Set;Development;Developmental Biology;Developmental Process;Disease;Disease Progression;Doctor of Philosophy;doctoral student;Educational process of instructing;Embryonic Development;Engineering;experimental study;Family;Fellowship;Frequencies;Funding;Gene Expression;Gene Expression Profile;Genetic Transcription;Genome;genome editing;Goals;Grant;Heritability;Heterogeneity;Image;image processing;In Situ;Individual;insight;Investigation;Knowledge;large scale data;Learning;Maps;Measurement;Methods;model organism;Modeling;Molecular;Mus;Mutation;Neurobiology;Neurons;novel;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Paper;Pattern;pharmacologic;Positioning Attribute;Procedures;Process;progenitor;programs;Publications;reconstruction;Recording of previous events;regenerative;Regenerative Medicine;Research;Research Personnel;Resolution;Rest;Retina;Retinal Diseases;retinal progenitor cell;Role;Sampling;Seminal;Series;Signal Transduction;single molecule;single-cell RNA sequencing;Spatial Distribution;Statistical Models;statistics;Stochastic Processes;Structure;student mentoring;symposium;System;Techniques;Technology;Time;Tissues;tool;Training Programs;transcriptomics;Trees;visual stimulus;Visualization;Work;Writing

PROJECT_TITLE: Determining the cell fate programs of mammalian retina development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-U(20)L]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Regenerative Medicine;Wound Healing and Care

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: || Project Narrative Lifesaving surgeries in blood vessels of the heart often fail due to poor or delayed healing of cells lining the blood vessel wall, putting patients at risk for stroke, heart attack, and death. My proposal aims to understand what controls the cells during healing and to identify ways to improve blood vessel repair. In the long term, my research aims to provide information that could be used to create therapies to reduce disease burden and increase patient survival.

PI_NAMEs: SEDOVY, MEGHAN W (contact)

PROJECT_TERMS: Alanine;animal facility;Antibodies;Aorta;Area;Arteries;Biological;Biology;Biomedical Research;Blood Vessels;burden of illness;C-terminal;Carotid Arteries;Cell Communication;Cell Culture Techniques;cell growth;cell injury;Cell Line;cell motility;Cell Proliferation;Cell Separation;Cells;Cessation of life;Communication;Confocal Microscopy;Connexin 43;Connexins;Coronary artery;Coronary Thrombosis;Data;Data Analyses;Defect;Deoxyuridine;design;Disease;Endothelial Cells;endothelial regeneration;endothelial repair;Endothelium;Ensure;Environment;Equipment;experience;experimental study;Failure;Fellowship;Female;Gap Junctions;Gene Modified;Genetic;Goals;healing;Health;Heart;Home;Hour;Human;Immunofluorescence Immunologic;Impaired healing;Impairment;improved;in vivo;in vivo Model;Injections;injured;Injury;Investigation;Knock-out;Knockout Mice;Legal patent;Life;Ligation;Link;male;Measures;Mediating;Mentorship;Microscope;migration;mimetics;Mission;Modeling;Modernization;Modification;Mus;Mutation;Myocardial Infarction;novel;Operative Surgical Procedures;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphorylation Inhibition;Phosphorylation Site;Phosphotransferases;Plasmids;Post-Translational Protein Processing;Preparation;Process;Proliferating;Proliferation Marker;protein expression;Proto-Oncogene Proteins c-akt;repaired;Research;Research Institute;Research Personnel;response;restenosis;Role;Saphenous Vein;Serine;sex;Signal Pathway;Signal Transduction;Site;Stents;stroke risk;Survival Rate;Technical Expertise;Techniques;Testing;Therapeutic;therapeutic target;Thrombus;Tissues;Training;transcriptome sequencing;Transfection;Travel;United States National Institutes of Health;Universities;Up-Regulation;Vascular Diseases;Vascular Endothelial Cell;Vascular Graft;vascular injury;Virginia;Western Blotting;Work;wound closure;wound healing

PROJECT_TITLE: The role of endothelial connexins in vascular wound repair


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Social interactions between individuals are the hallmark of human society, defined to be a dynamical process shaped by the neural and behavioral processes of all participating individuals — yet traditional approaches to investigate social behaviors mainly focus on the neural processes within a single individual. Through a multi- brain approach that integrates a novel machine-learning approach with state-of-the-art calcium imaging, this project aims to characterize inter-brain synchrony (inter-brain neural correlation) at higher dimensions, thus capturing the dynamical inter-animal properties during social interaction. Through the proposed approach, this research will uncover novel and impactful insights on how inter-brain synchrony emerges across genetically- defined neuronal subpopulations in the medial prefrontal cortex during social interaction, and how this property is altered in Autism Spectrum Disorder — a neurodevelopmental disorder strongly marked by impaired social interaction.

PI_NAMEs: PHI, NGUYEN THANH (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Address;Adopted;Animals;autism spectrum disorder;Behavior;Behavioral;Biological Markers;Brain;Calcium;cell type;Cells;Cognitive;cognitive process;Complex;Dedications;Development;Disease;dyadic interaction;Ethology;Exhibits;experimental study;Feedback;Future;Glutamates;Health;high dimensionality;hippocampal pyramidal neuron;Human;Image;Impairment;in vivo calcium imaging;Individual;insight;Interneurons;Investigation;Machine Learning;Medial;Mental disorders;Methods;model of autism spectrum disorder;mouse model;Mus;mutant;Mutant Strains Mice;Nature;Nervous System Disorder;neural;neural circuit;neural correlate;neural patterning;Neurodevelopmental Disorder;neuroimaging;Neurons;neuropsychiatric disorder;novel;novel strategies;Participant;Population;Prefrontal Cortex;Process;Property;Reaction;repetitive behavior;Research;response;Schizophrenia;sensory input;Shapes;social;Social Behavior;social deficits;Social Environment;Social Facilitation;social implication;Social Interaction;social neuroscience;Societies;Symptoms;Systems Integration;Techniques;Thalamencephalon;Work

PROJECT_TITLE: Neural Basis of Inter-brain Synchrony during Social Interaction in Health and Disease


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Recovery Support Services;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE This project is relevant to public health because it will determine the efficacy of an intervention providing HIV prevention alongside treatment for opioid use disorder. The availability of HIV self-testing and pre-exposure prophylaxis (PrEP) make it imperative to develop and implement interventions to increase their uptake.

PI_NAMEs: ASSOUMOU, SABRINA A (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Acceleration;acceptability and feasibility;addiction;Address;Adherence;Adopted;Adoption;Affect;AIDS prevention;arm;Automobile Driving;Behavior Therapy;Behavioral;Biometry;Blood;Boston;Buprenorphine;care fragmentation;Caring;Cellular Phone;Clinic;Clinical Laboratory Improvement Amendments;cocaine use;Communicable Diseases;Communities;contextual factors;Control Groups;County;Data;Diphosphates;Dose;Drug user;Dryness;Effectiveness;efficacy evaluation;Enrollment;Epidemic;Evaluation;evidence base;Evidence based intervention;experimental study;Foundations;Future;Goals;heroin use;HIV;HIV risk;Home;Human;Human immunodeficiency virus test;immunodeficiency;improved;improved outcome;Individual;Infection;informant;Injecting drug user;interest;Intervention;Laboratories;long term recovery;Measures;Medical;Medical center;medication for opioid use disorder;Methadone;Methods;Mission;Modeling;mortality;motivational enhancement therapy;motivational intervention;multidisciplinary;National Institute of Drug Abuse;novel;Opioid;opioid epidemic;opioid overdose;opioid use disorder;Outcome;outreach;Overdose;Participant;participant interview;Patients;peer;peer coaching;peer recovery;Persons;Pharmaceutical Preparations;Pharmacy facility;Phase;Pilot Projects;pilot test;point of care;Population;Populations at Risk;pre-exposure prophylaxis;prevent;Prevention strategy;primary outcome;Privacy;process evaluation;programs;Public Health;Qualitative Methods;Qualitative Research;Randomized;Randomized, Controlled Trials;rapid test;rapid testing;Recommendation;Records;Recovery;recruit;Research;Research Methodology;response;scale up;secondary outcome;Self Efficacy;Self Perception;self testing;Site;skills;Social Behavior;social stigma;Spottings;substance use;Substance Use Disorder;syndemic;Tenofovir;Testing;theories;therapy development;Training;treatment as usual;Treatment Efficacy;trial design;United States National Institutes of Health;uptake;Venous blood sampling;Walking

PROJECT_TITLE: PrEP and MOUD Rapid Access for Persons who Inject Drugs: the CHORUS+ Study


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases;Rehabilitation

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Many consider proton beam radiotherapy (PBRT) to be a promising treatment for children with brain tumors as it may preserve cognitive functioning without sacrificing disease control. This will be the first large-scale study to prospectively compare symptom burden, treatment toxicity, and neurocognitive change between patients treated with PBRT vs. conventional photon radiotherapy on comparable treatment protocols and to assess important measures of daily functioning that will quantify the clinical significance of any differences identified between groups in survivorship. Ultimately, this line of research is intended to: (1) help physicians and families better understand the relative effect of PBRT on symptoms and neurocognitive functioning to inform treatment decisions, and (2) provide functional outcome data to be used toward justifying or reconciling the high cost and access limitations currently associated with PBRT.

PI_NAMEs: HINDS, PAMELA S;KAHALLEY, LISA SCHUM (contact);MABBOTT, DONALD

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: Acceleration;Adverse effects;Affect;Aftercare;Attention;Australia;Awareness;Benefits and Risks;Brain;Brain Neoplasms;brain tissue;Canada;Cancer Center;Cancer Patient;Child;Childhood Brain Neoplasm;Childhood Injury;Clinical;clinically significant;Cognitive;cognitive function;cohort;contextual factors;cost;Costs and Benefits;Cranial Irradiation;daily functioning;Data;Decision Making;Deposition;design;Development;disability;Disease;disorder control;Dose;Education;Exhibits;experience;Face;Family;Fatigue;functional independence;functional outcomes;Goals;Hospitals;Impact evaluation;Impaired cognition;improved;Knowledge;Late Effects;Lead;Life;Longitudinal cohort;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mediating;Medical;member;Methodology;Modality;Modeling;multidisciplinary;Neurocognitive;Neurocognitive Deficit;neurodevelopment;neurotoxicity;Normal tissue morphology;North America;Occupational;Outcome;Patients;Pediatric Hospitals;Pediatric Oncology Group;Photons;Physicians;Population;Positioning Attribute;predictive modeling;preservation;Process;prospective;Protocols documentation;proton beam;Protons;Quality of life;Radiation;radiation delivery;Radiation therapy;Radiation Toxicity;recruit;reduce symptoms;Research;Research Infrastructure;Risk;Sampling;Short-Term Memory;Site;social;Social Problems;Socioeconomic Status;standard of care;Survivors;survivorship;Symptom Burden;symptom treatment;Symptoms;Texas;theories;Time;Tissues;Toxic effect;treatment group;Treatment Protocols;Treatment-related toxicity;tumor;Work;x-ray irradiation

PROJECT_TITLE: Comparison of Symptom Burden/Toxicity, Neurocognitive Change, and Functional Outcomes in Pediatric Brain Tumor Patients Treated with Proton vs. Photon Radiotherapy.

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation;Tourette Syndrome

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The proposed research is directly relevant to public health because it will increase our understanding of the physiological underpinnings of Tourette Syndrome, and it will inform approaches for deep brain stimulation of different brain targets to both monitor and to suppress tics. This research will contribute to the development of personalized therapies, such as closed-loop deep brain stimulation, and the research will have the impact of improving quality of life for patients suffering from this disorder.

PI_NAMEs: BUTSON, CHRISTOPHER R;GUNDUZ, AYSEGUL ;OKUN, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: ROBINSON SCHWARTZ, SARAH ELIZABETH

PROJECT_TERMS: Address;Adverse effects;Adverse event;Affect;Animal Model;Anterior;Basal Ganglia;battery life;Behavior Therapy;Behavioral tic;Bilateral;Brain;Centromedian Thalamic Nucleus;Characteristics;Chronic;Clinical;connectome;Country;Data;data repository;Databases;Deep Brain Stimulation;Detection;Development;Devices;Disabling;Disease;effective therapy;Electrophysiology (science);experience;FDA approved;feasibility testing;Follow-Up Studies;Foundations;Functional Imaging;Generations;Gilles de la Tourette syndrome;Globus Pallidus;Goals;Hour;Human;Image;Implant;improved;Informatics;International;Knowledge;Lead;Location;Longitudinal Studies;Maps;Medical;Methods;Monitor;Motor Tics;Movement;neural;neurophysiology;neuroregulation;next generation;novel;Operative Surgical Procedures;Outcome;Pathologic;Patients;personalized medicine;Pharmaceutical Preparations;Physiological;Physiology;Postoperative Period;primary outcome;prospective;Public Health;Publications;Quality of life;Registries;Research;Resistance;response;Safety;safety outcomes;safety testing;Self-Injurious Behavior;Severities;Signal Transduction;social;Stigmatization;structural imaging;Structure;Symptoms;Syndrome;System;Testing;Thalamic structure;tic suppression;Time;Vocal Tics

PROJECT_TITLE: Defining Targets for Tic Detection and Suppression in Tourette Syndrome Deep Brain Stimulation

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: This renewal application seeks support for the infrastructure maintenance of the Multiethnic Cohort (MEC) Study, established in 1993-1996, to continue a well-integrated program of research testing innovative hypotheses aimed at ensuring that racial/ethnic disparities are investigated and progress in disease prevention applies to major US racial/ethnic minorities. By including 215,251 men and women mostly of 5 racial/ethnic populations (African Americans, Japanese Americans, Latinos, Native Hawaiians and Whites), the MEC is the most racially and ethnically diverse cancer cohort, and its value for etiologic research on chronic diseases is widely recognized. Leadership of the MEC entails a highly interactive, team-science approach; investigators have amply demonstrated willingness to share data and samples.

PI_NAMEs: HAIMAN, CHRISTOPHER ALAN;LE MARCHAND, LOIC  (contact);WILKENS, LYNNE R

PROGRAM_OFFICER_NAME: MAHABIR, SOMDAT

PROJECT_TERMS: actigraphy;African American population;Aliquot;Anthropometry;Bayesian Modeling;biobank;Biological Markers;Blood;blood product;Blood specimen;Calibration;California;Cancer health equity;Cessation of life;Chemicals;Chronic Disease;climate change;Clinical;cohort;Cohort Studies;complex data;computerized;Computerized Medical Record;Consultations;Cost efficiency;Cryopreservation;Cultural Diversity;Data;Data Analyses;data harmonization;Data Management Resources;Data Security;Data Set;data sharing;database of Genotypes and Phenotypes;Databases;design;Diagnosis;Diagnostic;dietary;Dietary intake;digital repositories;Disease Outcome;disorder prevention;Energy Intake;Energy Metabolism;Ensure;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;epigenomics;ethnic difference;ethnic disparity;ethnic diversity;ethnic health disparity;ethnic minority;Ethnic Origin;Ethnic Population;Etiology;follow-up;Funding;Genetic;genetic risk factor;genome wide association study;Genomics;Genotype;Geographic Locations;Grant;Hawaii;Health;Health behavior;Health equity research;Hospitals;improved;Incidence;indexing;Indirect Calorimetry;Infrastructure;innovation;Intake;Japanese American;Latino Population;Leadership;Life Style;Lymphocyte;Maintenance;Malignant Neoplasms;Measurement;Measures;Medical;Medicare/Medicaid;member;men;metabolomics;Methodology;microbiome research;multi-ethnic;Native Hawaiian;Neighborhoods;neoplasm registry;Normal tissue morphology;novel strategies;nutrition;Oral;Outcome;Paper;Participant;Phenotype;Physical activity;Physiological;Pilot Projects;Planning Techniques;Postdoctoral Fellow;programs;prospective;Prospective, cohort study;Publishing;Questionnaires;Race;racial disparity;racial diversity;racial health disparity;racial minority;racial population;Registries;Research;Research Methodology;Research Personnel;Research Project Grants;Residual state;Resources;Rest;Risk Factors;Saliva;Sampling;Science;Slide;Social Environment;social health determinants;Specimen;stool sample;Structural Racism;Students;Testing;Tissue Banks;Tissue Sample;Training;tumor;tumor registry;Tumor Tissue;United States National Institutes of Health;Urine;Vertebral column;Vital Statistics;web platform;willingness;Woman

PROJECT_TITLE: Understanding Ethnic Differences in Cancer: The Multiethnic Cohort Study

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome

ORG_CITY: AMHERST

ORG_DEPT: MISCELLANEOUS

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: NARRATIVE We propose a 12-week Buffalo Research Innovation in Genomic and Healthcare Technology (BRIGHT) short-term training and education program at the University at Buffalo’s Jacobs School of Medicine and Biomedical Sciences in the Department of Biomedical Informatics. Every year this program will host 12 top undergraduate and master’s candidates for intensive training in Biomedical Informatics and Data Science involving didactics, hands-on research, and career development activities. Our overall objective is to recruit and train diverse undergraduate and masters’ students to prepare them for future careers in Biomedical Informatics and Data Science.

PI_NAMEs: ELKIN, PETER L. (contact);SAMUDRALA, RAM

PROJECT_TERMS: Biology;biomedical informatics;career;career development;college;Communication;Data Science;data science education;Discipline;Education;education research;Educational process of instructing;Employment;experience;Faculty;faculty mentor;field study;Fostering;Foundational Skills;Future;Genomics;Goals;Graduate Education;hands on research;Health;Health Technology;Healthcare;Human;improved;innovation;interest;International;Knowledge;knowledge base;Learning Module;lectures;medical schools;Medicine;multidisciplinary;Nature;next generation;novel;Ontology;outreach program;Population;programs;Public Health;recruit;Research;research and development;Research Personnel;Research Project Grants;Science;skill acquisition;skills;Students;symposium;Talents;Time;Training;Training and Education;undergraduate student;Underrepresented Students;Universities;Writing

PROJECT_TITLE: Buffalo Research Innovation in Genomic and Healthcare Technology (BRIGHT) Short-Term Training and Education


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Kidney Disease

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Project Narrative  Roughly one-third of the 500,000 patients who undergo cardiac surgery in the U.S. annually will develop postoperative delirium, and another 25% develop acute kidney injury. Each of these organ dysfunctions is associated with worse clinical outcomes. Impaired vascular reactivity may be an important underlying mechanism to the development of perioperative brain and kidney injury that is currently not routinely addressed in clinical care. This study will randomize cardiac surgery patients to a soluble guanylyl cyclase stimulator which may enhance vascular reactivity, and measure effects on vascular reactivity and cellular markers of neuronal and renal tubule injury.

PI_NAMEs: LOPEZ, MARCOS G (contact)

PROGRAM_OFFICER_NAME: FENTON, KATHLEEN NELLE

PROJECT_TERMS: Acetylcholine;Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Affect;Animal Model;arteriole;Binding;Biological Markers;Biology;Blood Vessels;brachial artery;Brain Injuries;Cardiac Surgery procedures;Cells;Chronic Kidney Failure;Clinical;clinical care;Coagulation Process;Collection;Conduct Clinical Trials;Congestive Heart Failure;Cyclic GMP;Cyclic GMP-Dependent Protein Kinases;Data;Delirium;Development;Diffusion;Disodium Salt Nitroprusside;endothelial dysfunction;Endothelium;Enzymes;experience;experimental study;Fatty acid glycerol esters;Free Radicals;Functional disorder;Future;glomerulosclerosis;Heart failure;Heme;Hemoglobin;Herpes zoster disease;Hospitalization;Human;immune activation;Impairment;improved;in vivo;Inflammation;Infrastructure;Injury;Injury to Kidney;insight;insulin-like growth factor binding protein-related protein 1;Intercellular adhesion molecule 1;iron oxidation;Kidney;LCN2 gene;Mammary Arteries;Measurement;Measures;Mechanical ventilation;Mediastinal;Mediating;Molecular Conformation;mortality;mortality risk;Muscle relaxation phase;Muscle Tonus;Neuronal Injury;Neurons;Nitric Oxide;Nitric Oxide Donors;NOS3 gene;Operative Surgical Procedures;Organ;organ injury;Outcome;Oxidants;oxidation;Oxidative Stress;Oxygen;Participant;Pathway interactions;Patients;Perfusion;Perioperative;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Placebos;Plasma;Plasminogen Activator Inhibitor 1;Population;Positioning Attribute;postoperative delirium;preclinical study;pulmonary arterial hypertension;Randomized;randomized, clinical trials;Recovery;recruit;Renal tubule structure;Research Design;response;Risk;Role;Sampling;Second Messenger Systems;Secondary to;Signal Transduction;Site;Smooth Muscle;Soluble Guanylate Cyclase;Techniques;Testing;TIMP2 gene;Tissue Inhibitor of Metalloproteinases;Tissues;treatment group;Tubular formation;ubiquitin C-terminal hydrolase;urinary;Urine;Vascular Diseases;Vascular Endothelium;vascular factor;Vascular Smooth Muscle;Vasodilator Agents;vasodilator-stimulated phosphoprotein

PROJECT_TITLE: The effects of soluble guanylyl cyclase stimulation on perioperative vascular reactivity and organ injury in cardiac surgery trial

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The project proposed here will investigate how Aa Cdt-mediated change in phosphoinositides disrupt macrophage function and lead Aa survival contributing to disruption of local host defense. By testing LGM2605, our studies may provide a novel therapeutic approach to decrease the inflammatory response to mitigate periodontitis.

PI_NAMEs: KIM, TAEWAN JOHN (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Actinobacillus actinomycetemcomitans;alveolar bone;Anti-Inflammatory Agents;Antiinflammatory Effect;Antioxidants;Apoptosis;Award;Bacteria;bone loss;Bone remodeling;career;career development;Cell Cycle Arrest;Cells;chronic inflammatory disease;Colony-forming units;Connective Tissue;cytokine;cytolethal distending toxin;Dental Schools;Dentistry;Diphosphates;Disease;disease model;dysbiosis;Education;Effectiveness;Endocytosis;Endosomes;Enrollment;Environment;Etiology;Event;Experimental Models;Free Radical Scavengers;Future;Gingiva;glycogen synthase kinase 3 beta;Goals;holotoxins;Host Defense;Human;Immune response;Immune system;Immunotoxins;In Vitro;in vivo;Incisor;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;innovation;Lead;Macrophage;Measures;Mediating;medical specialties;Medicine;Membrane;Mentorship;microbial;microbicide;microbiota;Modeling;monocyte;mouse model;mutant;novel;novel therapeutic intervention;Organism;osteoclastogenesis;Oxidative Stress;pathogen;Pathogenesis;Pathologic;Pattern;Pennsylvania;Periodontal Ligament;Periodontic specialty;Periodontitis;Periodontium;Phagocytes;Phagocytosis;Phagolysosome;Phagosomes;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Phosphotransferases;Play;Pre-Clinical Model;Process;Production;programs;Proteins;Reactive Oxygen Species;recruit;Research Personnel;response;Role;Science;secoisolariciresinol;Signal Transduction;small molecule therapeutics;spatiotemporal;Structure;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;Tooth Loss;Tooth structure;Toxin;trafficking;training opportunity;tripolyphosphate;Universities;Virulence Factors

PROJECT_TITLE: Cytolethal distending toxin mediated modulation of phagocytic function


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Substance Misuse

ORG_CITY: LUBBOCK

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

PHR: Public Health Relevance Statement (Project Narrative) Alcohol Use Disorder is a complex spectrum disorder that presents significant unmet clinical treatment challenges. Accumulating evidence indicates that the action of ethanol on the innate immune system leads to chronification of risky drinking, potential physical dependence, and often dangerous withdrawal symptoms. The proposed project is a collaboration with NIAAA’s Division of Medications Development and addresses creation of manufacturing standards for two lead compounds and IND enabling studies for FDA approval for a Phase I clinical trial.

PI_NAMEs: BERGESON, SUSAN E. (contact);SHEN, CHWAN-LI L

PROGRAM_OFFICER_NAME: SENEVIRATNE, CHAMINDI

PROJECT_TERMS: Acceleration;Acute;addiction liability;Address;Advisory Committees;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol seeking behavior;alcohol use disorder;analog;Animal Model;Animals;Antibiotic Resistance;Antibiotics;antimicrobial;Biological;Biotechnology;Chemicals;Clinical;clinical investigation;Clinical Research;Clinical Treatment;Collaborations;commercialization;comorbidity;Complex;Consultations;cost;Dangerousness;Data;Dependence;design;Development;Disease;Dose;drinking;DSM-V;Effectiveness;Ethanol;Excision;experience;FDA approved;Female;Future;gabapentin;Goals;Heavy Drinking;High Pressure Liquid Chromatography;high risk drinking;Human;Immune;improved;Innate Immune System;Investigational Drugs;Laboratories;Lead;Legal patent;Licensing;male;manufacture;Medical;Minocycline;Modeling;Modification;Morbidity - disease rate;National Institute on Alcohol Abuse and Alcoholism;Neuroimmune;neuroinflammation;novel;off-label use;Oral Administration;Ownership;Patients;Persons;Pharmaceutical Preparations;Pharmacology and Toxicology;Phase;Phase I Clinical Trials;Physical Dependence;Physiology;pre-clinical;Process;Property;public health relevance;Recording of previous events;Relapse;Research;Research Institute;Research Personnel;response;Rewards;Rights;Risk;side effect;stability testing;Structure;success;Symptoms;System;Testing;Tetracyclines;Texas;Therapeutic;therapy development;Toxicology;Universities;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Medication Development for the Treatment of Alcohol Use Disorder


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: SYRACUSE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SYRACUSE UNIVERSITY

PHR: Project Narrative Multiracial discrimination may be driving alcohol-related risks and disparities among Multiracial young adults; however, fragmented knowledge about Multiracial discrimination and measurement concerns disallows alcohol researchers to test the Multiracial discrimination-alcohol misuse pathway. Using a sequential mixed methods approach, the proposed project will develop and psychometrically validate a Multiracial Discrimination Scale as informed by Multiracial young adults’ experiences of Multiracial discrimination, and test concurrent associations of Multiracial discrimination with alcohol misuse. The findings of this project will provide a psychometrically sound scale for alcohol researchers to investigate Multiracial discrimination as a sociocultural determinant of alcohol misuse, which in turn may further inform culturally sensitive intervention research to reduce and prevent alcohol misuse among Multiracial young adults.

PI_NAMEs: DOBANI, FATIMA  (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Address;Age;aged;Alcohol consumption;alcohol misuse;alcohol misuse prevention;alcohol research;alcohol use disorder;Alcoholism;Alcohols;Automobile Driving;binge drinking;Biological;career;Characteristics;Data;design;Development;Dimensions;disadvantaged background;Discrimination;Disparity;drinking;Equation;Ethnic Origin;Ethnic Population;Evidence based intervention;experience;Factor Analysis;Family;Fellowship;First Generation College Students;Focus Groups;Frequencies;Funding;Geographic Locations;Health;Heterogeneity;high intensity drinking;High Prevalence;Individual;instrument;Intervention;Intervention Studies;Knowledge;Literature;Lived experience;Measurement;Mediation;member;Meta-Analysis;Methodology;Methods;minority stress;Modeling;multi-racial;National Institute on Alcohol Abuse and Alcoholism;National Research Service Awards;Outcome;Parents;Participant;Pathway interactions;Pattern;perpetrators;Persons;Population;pre-doctoral;preference;programs;Psychometrics;Race;racial discrimination;racial population;Reporting;Research;Research Personnel;Risk;Sampling;sex;Societies;sociocultural determinant;sociodemographics;sound;Source;Specificity;statistics;Strategic Planning;stressor;Structure;Techniques;Testing;theories;Training;training opportunity;United States;United States National Institutes of Health;university student;Validation;young adult

PROJECT_TITLE: Multiracial Discrimination Scale: Development and Psychometric Validation of its Associations with Alcohol Use and Misuse among Multiracial Young Adults


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Heart Disease;Hematology;Patient Safety;Rehabilitation;Stroke

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Atrial fibrillation is the most common heart rhythm disorder in older adults, and it substantially increases the risk of disabling strokes. Anticoagulant treatment reduces the risk of stroke but increases the likelihood of disabling bleeding events. We lack a way to individualize treatment decisions for older adults—this proposal will use multiple studies to better define the individual risk and benefits of anticoagulants in older adults with atrial fibrillation.

PI_NAMEs: SHAH, SACHIN J (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Activities of Daily Living;Address;Adverse event;Aging;Anticoagulant therapy;Anticoagulants;Atrial Fibrillation;Award;barrier to care;Benefits and Risks;California;Cardiovascular system;career development;Cephalic;Clinical;clinical epidemiology;clinical practice;Clinical Trials;cohort;Complement;Conflict (Psychology);Cryosurgery;Data;Data Collection;data resource;Decision Aid;Decision Making;Decision Modeling;Dependence;design;Development;Devices;Disability outcome;Disabling;Disease;Elderly;Enrollment;Epidemiologic Methods;Epidemiology;Event;experience;falls;follow-up;forest;Foundations;frailty;functional outcomes;functional status;Future;Goals;Grant;Guidelines;Health;Health and Retirement Study;Heart Atrium;heart rhythm;Hemorrhage;Heterogeneity;high risk;Hospitalization;Hospitals;human centered design;Impairment;improved;Individual;individualized medicine;Institution;Internal Medicine;Intervention;investigator training;Ischemic Stroke;K-Series Research Career Programs;Lead;leadership development;Left;Life Expectancy;machine learning method;machine learning model;Measures;Medicine;Mentors;Mentorship;Methods;Modeling;Modernization;multidisciplinary;novel;older adult;Outcome;Patients;Physicians;Placebo Control;Population;Procedures;professor;programs;Prospective cohort;Recommendation;Recovery of Function;Reporting;Research;Research Personnel;Risk;Risk Reduction;San Francisco;Series;side effect;Specific qualifier value;Stream;Stroke;Stroke prevention;stroke risk;Syndrome;Testing;Therapeutic;tool;Training;treatment effect;trend;Universities;Validation;Voice;Work

PROJECT_TITLE: Individualizing Anticoagulant use in Older Adults with Atrial Fibrillation


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hematology

ORG_CITY: SEATTLE

ORG_NAME: BLOODWORKS

ORG_STATE: WA

PHR: PROJECT NARRATIVE Platelet activation due to cold temperatures has important implications for public health. Platelets for transfusion are currently stored at room temperature, which maximizes circulation time, but reduces function, limits storage time, facilitates bacterial growth and thereby increases the risk for sepsis. By investigating the underlying mechanism for the response of platelets to cold temperatures and by examining the role of TRPM8 for platelet cold‐storage and platelet function after transfusion in humans we will open up avenues for increasing the availability, safety, and quality of platelet transfusions in patients.

PI_NAMEs: STOLLA, MORITZ  (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: Affect;afferent nerve;Agonist;Aspirin;Autologous;Biological Assay;Bleeding time procedure;Blood Cells;Blood Platelets;Body Temperature;Calcium Signaling;Cations;Circulation;Clinical;clopidogrel;cold temperature;Cryopreservation;Cytoskeleton;Data;Detection;Environment;Eucalyptol;Exclusion;Exposure to;Family;Generations;Genetic;Goals;Growth;Heart Arrest;Hemostatic function;Human;human subject;human tissue;icilin;improved;In Vitro;in vitro Assay;in vivo;Incubated;individual response;inhibitor;Integrins;Ion Channel;Life;Lipids;Mediating;Membrane;Menthol;Molecular;Morphology;mouse model;Mus;Myocardial Infarction;natural hypothermia;Nerve;Nervous System;novel strategies;Pathway interactions;Patients;pharmacologic;Phase I Clinical Trials;Platelet Activation;Platelet aggregation;platelet function;platelet phenotype;platelet storage;Platelet Transfusion;preservation;prevent;Prevention;Public Health;Radiolabeled;Reaction;Reagent;receptor;Receptor Activation;Recovery;response;Risk;Role;Safety;sensor;Sepsis;side effect;small molecule;Stimulus;Temperature;Therapeutic;Thrombelastography;Thrombin;Thrombosis;Time;Tissues;Transfusion;TRP channel

PROJECT_TITLE: Role of TRPM8 in Cold-stored Platelet Transfusions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-D(55)R]


ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative As the senior research scientist, I am leading the research in Dr. Binghui Shen’s NCI-sponsored research programs to define the function of structure-specific nucleases in maintaining genome integrity for cancer suppression. My research will define etiological mechanisms by which human mutations that cause functional deficiency of these nucleases promote cancer development. Such important new knowledge will inform future development of personalized chemoprevention or chemotherapy drugs.

PI_NAMEs: ZHENG, LI  (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Androgen Receptor;Award;Biochemical;Cells;Cellular Assay;Centromere;Chemoprevention;chemotherapy;Cities;Collaborations;Complex;Deposition;Development;DNA;DNA biosynthesis;DNA Ligation;DNA Repair;DNA Structure;Etiology;Event;Exonuclease;experience;Funding;Future;Gene Mutation;gene repair;Genes;genome integrity;Genome Stability;Genomic Instability;Goals;helicase;Histones;Human;Institution;Knockout Mice;Knowledge;Laboratories;Lead;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Metabolism;Molecular;mouse genetics;mutant mouse model;Mutation;next generation sequencing;nuclease;Okazaki fragments;Peer Review;Pharmaceutical Preparations;Play;Post-Translational Protein Processing;Prevention therapy;Process;programs;Prostate;Publications;Regulation;repaired;replication stress;Research;Research Institute;Resected;Resources;Role;RTH-1 Nuclease;Science;Scientist;Specialist;Structure;Technology;telomere

PROJECT_TITLE: Functional Analysis of Structure Specific Nucleases in Genome Stability and Cancers


ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE The androgen receptor is a type I nuclear hormone receptor and master transcription factor responsible for differentiation and development of the male phenotype. Its hyperactivation is associated with multiple diseases, including metastatic prostate cancer, androgenetic alopecia, androgen insensitivity syndrome, and Kennedy’s disease. This proposal seeks to understand the mechanism of androgen receptor regulation and determinants of its aberrant activity using biochemical, structural, and cellular methods, which can facilitate the development of novel androgen receptor inhibitors and lend mechanistic insight towards other related nuclear hormone receptors.

PI_NAMEs: WASMUTH, ELIZABETH VICTORINA (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acceleration;Affinity;Androgen Antagonists;androgen independent prostate cancer;Androgen Receptor;Androgen-Insensitivity Syndrome;Androgens;Architecture;Atomic Force Microscopy;Binding;Biochemical;Biological;Biological Assay;Biology;Cancer Biology;career;cell growth;Cell Line;Cells;Cellular Morphology;ChIP-seq;Chromatin;cofactor;Communication;Complex;computerized data processing;Consensus;Cryoelectron Microscopy;data acquisition;Dedications;design;Development;Dimerization;Disease;Dissection;DNA;DNA Binding;DNA Binding Domain;Drug Targeting;Electron Microscopy;Electrons;enzalutamide;Etiology;experience;flexibility;functional outcomes;Generations;genetic corepressor;Genetic Transcription;Global Change;Glucocorticoid Receptor;Goals;Growth;Health;human disease;improved;In Vitro;in vivo;inhibitor;innovation;insight;Joints;Kennedy Syndrome;Knowledge;Laboratories;Leadership;Lentivirus;Ligand Binding Domain;Maintenance;male;Male Pattern Baldness;Malignant neoplasm of prostate;Mediating;Memorial Sloan-Kettering Cancer Center;Metastatic Prostate Cancer;Methods;Mineralocorticoid Receptor;Modeling;Molecular;Molecular Conformation;mutant;Mutate;Mutation;N-terminal;National Institute of General Medical Sciences;Negative Staining;novel;Nuclear Hormone Receptors;Nucleoproteins;Output;particle;Phenotype;Phenotypic Sex;post-doctoral training;Process;Progesterone Receptors;Prostate;prostate cancer cell;protein protein interaction;protein purification;Proteins;Receptor Activation;receptor binding;Receptor Inhibition;Receptor Signaling;Recombinant Proteins;Recombinants;Regulation;Reporter;Reporting;Research;Research Personnel;Resolution;Running;Sex Differentiation;Sexual Development;Site;skills;Stanolone;structural biology;structural determinants;Structural Models;Structure;Surface;System;Technology;Testing;Testosterone;three-dimensional modeling;Training;Transactivation;Transcript;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;Universities;Validation;Variant;Work;X-Ray Crystallography

PROJECT_TITLE: Biochemical, structural and molecular dissection of androgen receptor transcriptional activity


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Prevention

ORG_CITY: STONY BROOK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative Over 20 million people suffer from bilateral cataracts in the U.S., which is projected to double by 2050 (NEI); age-related cataract represents 48%, while diabetes, smoking, alcohol consumption, etc., add to the risk and related healthcare costs. The studies outlined in this research proposal will provide novel insights into the molecular mechanisms by which lens membrane channels AQP0, AQP1 and AQP5, and cytosolic GPX1 enzyme protect the lens from oxidative damage to maintain lens transparency, refractive index gradient, microcirculation and homeostasis, and how aging causes abnormal optical aberrations and cataract. The molecular understanding envisaged and the data that will be collected will have the potential to aid in developing therapeutic strategies to delay, treat or prevent age-related cataracts to improve the quality of life for millions and reduce healthcare costs.

PI_NAMEs: VARADARAJ, KULANDAIAPPAN  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acceleration;Acidosis;Affect;Age;Age Months;Age of Onset;age related;age related changes;Aging;Alcohol consumption;Applications Grants;Bilateral;Calcium;Cardiovascular system;Cataract;Cell Adhesion;Cell Membrane Permeability;Cell Nucleus;Circulation;cofactor;Connexin 43;Connexins;Coupling;Crystallins;Cytoplasm;Data;Development;Diabetes Mellitus;Diet;Dose;Drops;Drug Metabolic Detoxication;ebselen;Enzymes;Epithelial Cells;Epithelium;Equilibrium;Exposure to;extracellular;Fiber;fiber cell;gap junction channel;Gap Junctions;Glutathione;Glutathione Disulfide;glutathione peroxidase;Goals;Health Care Costs;Homeostasis;Hydrogen Peroxide;Hydrostatic Pressure;Hydroxyl Radical;improved;insight;invention;Ion Channel;K ATPase;Knock-out;Knockout Mice;Knowledge;lens;lens gap junction;Lens Opacities;lens transparency;Ligase;loss of function;malformation;Membrane;Membrane Proteins;Metabolic;Metabolism;Microcirculation;MIP gene;Mitochondria;Modeling;Molecular;mouse model;Mus;Mutation;neurotensin mimic 1;novel;novel therapeutic intervention;Nutrient;Optics;Oxidants;Oxidation-Reduction;oxidative damage;Oxidative Regulation;Oxidative Stress;Oxidative Stress Induction;Oxidoreductase;Peripheral;Permeability;Persons;Play;prevent;Prevention;protein aggregation;Proteins;Quality of life;Refractive Indices;Research Proposals;Review Literature;Risk;Role;Selenium;Smoking;Surgical sutures;Testing;Therapeutic;therapeutically effective;Time;Transgenic Mice;Ultraviolet Rays;Up-Regulation;Visual impairment;wasting;water channel;Work;Zinc

PROJECT_TITLE: Roles of Lens Aquaporins and GPX1 in Hydrogen Peroxide Balance, Homeostasis, and Aging

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Atherosclerosis;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Palliative Care;Prevention

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Low statin adherence and early discontinuation is too common, and it results in substantially increase risks of experiencing atherosclerotic cardiovascular disease (ASCVD) events. Statin-associated muscle symptoms (SAMS), a spectrum of muscle symptoms the patient perceives as intolerable enough to impair daily activities and quality of life, is a major, yet manageable cause of low statin adherence and early discontinuation. We propose to evaluate a novel, multicomponent technology embedded within a team-based health service to empower patients with SAMS to self-manage their statin therapy to ultimately increase statin adherence and persistence and, thereby, ultimately reduce ASCVD risk among patients with SAMS.

PI_NAMEs: KING, JORDAN BRADLEY (contact)

PROGRAM_OFFICER_NAME: MASTERSON, MARY YAA SEDEGAH

PROJECT_TERMS: Address;Adherence;Adoption;Adult;Affect;Atherosclerosis;Behavior;Belief;Biological Markers;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Caring;Cessation of life;Cholesterol;Classification;Clinical;clinical practice;Clinical Psychology;Cognitive;Collection;compare effectiveness;Computer software;cost;Cross-Over Trials;Development;Diagnosis;Dose;effective intervention;Effectiveness;effectiveness-implementation randomized trial;effectiveness/implementation trial;empowerment;Event;evidence base;Evidence based practice;experience;follow-up;health information technology;Health Services;Healthcare;Human Resources;Hybrids;Impairment;implementation strategy;improved;indexing;innovation;insight;Interdisciplinary Study;Intervention;iterative design;Kidney;Literature;Liver;Modeling;Modification;mortality;Muscle;new technology;novel;Online Systems;Outcome;Partner in relationship;patient engagement;Patient Preferences;Patient Self-Report;patient-level barriers;Patients;Pharmaceutical Preparations;Pharmacists;Physicians;Placebo Effect;Placebos;premature;prevent;Protocols documentation;Provider;Psychology;Psychophysiologic Disorders;Public Health;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recurrence;Regimen;Research;Resistance;Resources;Risk;Risk Management;Safety;Self Management;Source;symptom management;symptom treatment;Symptoms;System;team-based care;Technology;Testing;theories;Time;treatment as usual;uptake;usability;virtual;web-based intervention;web-based tool;Work

PROJECT_TITLE: Development, testing, and implementation of virtual statin associated muscle symptom (SAMS) management

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Eating Disorders;Mental Health;Nutrition

PHR: PROJECT NARRATIVE Functional dyspepsia (FD) is a chronic gastrointestinal functional/motility disorder which frequently poses detrimental and problematic eating-related medical consequences (e.g., significant weight loss, malnutrition) with avoidant/restrictive food intake disorder (ARFID) present in up to 40% of adults with FD. While treatment options for FD are limited, presence of problematic avoidant/restrictive food intake has not yet been explored to inform treatment approaches and our team’s uncontrolled pilot data suggest that an exposure-based cognitive-behavioral treatment can improve FD outcomes. The proposed multi-disciplinary study aims to determine the role of problematic avoidant/restrictive food intake by (1) comparing gastric sensorimotor functions and satiety hormones among adults with FD and ARFID, FD without ARFID, and healthy controls, and (2) testing the proof-of-concept of an exposure-based cognitive-behavioral treatment in a pilot randomized controlled trial.

PI_NAMEs: BURTON MURRAY, HELEN  (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Adult;Advisory Committees;Affect;Aftercare;Appetite Regulation;Applications Grants;Area;avoidant restrictive food intake disorder;Behavior Therapy;Behavioral;behavioral clinical trial;behavioral study;biobehavior;Biological;Biological Markers;Biological Response Modifier Therapy;biopsychosocial;Body Image;Body Weight decreased;career development;Cholecystokinin;Chronic;Clinical;Clinical Investigator;Clinical Trials;Cognitive Therapy;cohort;Complement;Data;Development;Diet;dietary approach;Dyspepsia;early satiety;Eating;Eligibility Determination;Endocrine;Enrollment;Enteral Feeding;Epigastric;Evaluation;experience;Exposure to;Food;food avoidance;Future;Gastroenterology;gastrointestinal;Gastroparesis;Goals;Health Care Costs;Hormones;Impairment;improved;improved outcome;Individual;innovation;interdisciplinary approach;Intervention;K-Series Research Career Programs;Learning;Malnutrition;Medical;meetings;Mentors;Mentorship;Morbidity - disease rate;motility disorder;Motor;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nausea;Nutritional status;Outcome;Pain;patient oriented research;Patients;Peptide YY;Phase;pilot test;Preparation;programs;Protocols documentation;Psychologist;Psychology;Quality of life;Randomized;Randomized, Controlled Trials;Research;Research Personnel;Research Priority;restrictive eating;Role;Satiation;satisfaction;Scientist;Sensorimotor functions;Severities;skills;social;Stomach;symptom management;Symptoms;Testing;Training;translational scientist;treatment as usual;treatment research;United States National Institutes of Health

PROJECT_TITLE: A Biobehavioral Approach to Understand Problematic Avoidant/Restrictive Eating in Adults with Functional Dyspepsia

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Columbus

ORG_DEPT: PHYSICS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Regulation of gene expression and cell differentiation by pioneer transcription factors and epigenetic factors is a major focus in cancer epigenetics because of the master regulator function of pioneer factors and the reversible nature of epigenetic alterations. Recent advances in understanding epigenetic factors have led to the emergence of epigenetic therapy and the recent FDA approval of multiple epigenetic drugs. This proposal uses a combination of in vitro biochemical, biophysical and single molecule methods, combined with in vivo genetic and cell biology approaches to reveal the molecular mechanisms behind the function of pioneer factors and these chromatin epigenetic regulators. Our studies will provide molecular information for understanding drug resistance, tumorigenesis and will help designing new drugs and therapies.

PI_NAMEs: POIRIER, MICHAEL GUY (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Aging;Binding Proteins;Binding Sites;Biochemical;Biology;Biophysics;Cell Differentiation process;Cellular biology;Chemicals;Chromatin;Collaborations;Complex;design;Development;Disease;Drug resistance;embryonic stem cell;epigenetic drug;Epigenetic Process;epigenetic therapy;Fluorescence;Foundations;Functional disorder;Gene Expression Regulation;Genetic;Genetic Transcription;Genome;Histone H3;Histones;Human;In Vitro;in vivo;Individual;insight;Ligation;Malignant Neoplasms;Methods;Molecular;Nature;novel therapeutics;Nucleosomes;Post-Translational Protein Processing;programs;Reader;Research;SAGA;single molecule;Site;Spectrum Analysis;Testing;tool;transcription factor;Transcriptional Regulation;tumorigenesis;Work;XCL1 gene

PROJECT_TITLE: Mechanisms of chromatin regulation of transcription

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Cancer

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE The work in this proposal will characterize the novel signaling activity through Dock7 that maintains low, but sustained AKT activity that is essential for transformation and cell survival under stressful conditions. The mechanistic insights into the assembly, function, and location of the Dock7/AKT/mTOR signaling complex from this work will provide a better understanding of the signaling activity and metabolism of cancer cells that drive tumorigenesis. Characterization of this novel signaling activity will aid in the treatment and management of cancer by supporting the identification of new potential targets for therapeutic intervention.

PI_NAMEs: ZANOTELLI, MATTHEW R (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Aggressive behavior;Anchorage-Independent Growth;Anoikis;Binding;Biochemical;biological adaptation to stress;C2 Domain;cancer cell;Cancer cell line;cancer survival;cancer therapy;Cell Survival;cell transformation;Cells;Cellular Stress;Characteristics;Complex;Cytokinesis;Dimerization;Docking;Exhibits;Exposure to;Family member;FRAP1 gene;Genetic;Growth;Growth Factor;GTP Binding;Guanine Nucleotide Exchange Factors;Human;Individual;insight;Intervention;Laboratories;Lipid Binding;Location;Lysosomes;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;Membrane;Metabolism;new therapeutic target;novel;Nutrient;nutrient deprivation;Oncogenic;Outcome;Phenotype;Phospholipids;Phosphorylation;PIK3CG gene;Play;Proteins;Proto-Oncogene Proteins c-akt;Ribosomal Protein S6 Kinase;Role;scaffold;Serum;Signal Pathway;Signal Transduction;Site;Starvation;Stress;Surface;targeted treatment;Therapeutic Intervention;therapeutic target;tumor metabolism;tumor progression;tumorigenesis;Work

PROJECT_TITLE: Probing a novel signaling complex that sustains AKT activation to support stress survival in cancer