NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE While early word learning is a developmental achievement that builds on a foundation of early category learning, it is unclear how children learn the visual categories that words refer to. The proposed work aims to use modern deep neural networks to understand how children’s visual experiences interact with statistical learning mechanisms to yield the category representations that support early word learning. This work will elucidate the relevant visual inputs and mechanisms for category learning and have the potential to inform interventions for children who struggle with early category learning, including late talkers, children with ASD, and children recovering from blindness.

PI_NAMEs: LONG, BRIA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Achievement;Adult;Age;Apple;Architecture;autistic children;Award;Behavioral;Blindness;Canis familiaris;Cataract Extraction;Categories;Child;Cognitive;cognitive development;Computer Models;crowdsourcing;Data;Data Set;deep neural network;Development;Diet;Educational Materials;Educational workshop;effective intervention;Environment;Exclusion;Exhibits;experience;experimental study;Foundations;Goals;improved;Infant;insight;Intervention;Knowledge;Label;Labrador;Language Delays;Language Development;Learning;learning outcome;Life;longitudinal dataset;Machine Learning;Measures;Mentors;Modeling;models and simulation;Modernization;neural;Neural Network Simulation;novel;Output;Parents;peer;Phase;Pomegranate;predictive modeling;Reporting;Research;Research Personnel;Rest;Risk;social;statistical learning;statistics;Stream;Surveys;Testing;Time;Training;vision science;Visual;visual learning;wolves;word learning;Work

PROJECT_TITLE: Grounding models of category learning in the visual experiences of young children


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: MATHER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VA NORTHERN CALIFORNIA HEALTH CARE SYS

ORG_STATE: CA

PHR: The research program of Aliza Wingo, MD, MSc, addresses the VA priority research areas including PTSD, Alzheimer’s dementia, women veteran’s health, and genomic medicine. Particularly, Dr. Wingo studies the genetic and molecular mechanisms that underlie the conditions that disproportionally affect Veterans - PTSD, depression, Alzheimer’s dementia, and detrimental effects of maternal PTSD on offspring outcomes. Another important aspect of Dr. Wingo’s research effort is to elucidate the genetic and molecular basis of resilience, conceptualized as adaptive coping in the context of stress, adversity, or trauma. In this novel and cutting-edge CDTA application, Dr. Wingo proposes to identify proteins in the human brain that i) predispose one to PTSD or depression, and ii) contribute to resilience after adverse or traumatic life experiences. From these studies, Dr. Wingo hopes to contribute to a better understanding of the neurobiology of PTSD, depression, and Alzheimer’s dementia in order to find more effective interventions and enhance resilience among Veterans.

PI_NAMEs: WINGO, ALIZA PHAM (contact)

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Anxiety;Area;Autopsy;Award;Awareness;Behavioral;Biological Models;Biological Psychiatry;Blood;Board Certification;Brain;brain tissue;career;Caring;Chromosome 1;Cognitive;Communication;comorbid depression;Complex;coping;Data;Data Set;Dementia;dementia risk;Development;DICER1 gene;Doctor of Medicine;effective intervention;Elderly;epidemiology study;Etiology;Event;experience;Female;Formulation;Funding;Future;Genes;Genetic;Genetic study;genetic variant;genome wide association study;Genomic medicine;Genotype;geriatric depression;Goals;Health;Healthcare;high risk;Human;Impaired cognition;Individual;innovation;intergenerational;Intervention;Journals;K-Series Research Career Programs;Life;Life Experience;Mass Spectrum Analysis;Meaning and purpose;Medical center;Mental Depression;Messenger RNA;Meta-Analysis;MicroRNAs;Modeling;Molecular;mRNA Expression;Multiomic Data;multiple omics;National Institute of Mental Health;Nature;Neurobiology;novel;novel therapeutic intervention;novel therapeutics;offspring;Outcome;Paper;Participant;Pathway interactions;Patient Care;positive emotional state;Post-Traumatic Stress Disorders;Prefrontal Cortex;Pregnant Women;Principal Investigator;programs;promote resilience;protective effect;protein expression;Proteins;Proteome;Proteomics;Psyche structure;Psychiatrist;Psychiatry;psychologic;Publications;Publishing;Regulation;Research;Research Personnel;Research Priority;resilience;resilience biomarker;Role;Seminal;Shapes;statistics;Stress;Symptoms;Systems Biology;Techniques;transcriptome;transcriptomics;Transition Career Development Award (K22);Translating;Trauma;United States National Institutes of Health;Veterans;Weight;Woman;Work

PROJECT_TITLE: BLR&D Research Career Development Transition Award Application


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF CHIROPRACTIC

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pain Research

ORG_CITY: DAVENPORT

ORG_NAME: PALMER COLLEGE OF CHIROPRACTIC

ORG_STATE: IA

PHR: PROJECT NARRATIVE There is a pressing need to address the devastating impact of cLBP in Veteran populations. Prior research indicates that chiropractic care, increasingly integrated into the VHA system, may have a positive impact. However, chiropractic care has not been studied in the Veterans. In addition, considerable uncertainty exists regarding optimal patterns of chiropractic use. The short-term pain and functional outcomes associated with varying numbers of initial visits, and the long-term effectiveness of chiropractic care within the context of real- world delivery at VHAs, in terms of clinical impact is unknown. In addition, we know very little regarding outcomes resulting from the broader range of evidence-based chiropractic care strategies most commonly practiced in real world settings. Thus, the proposed demonstration project - an appropriately powered multisite RCT specifically designed to rigorously address both of these issues - is highly significant and has the potential to directly impact chiropractic utilization policy within the VHA and beyond, regardless of outcome.

PI_NAMEs: GOERTZ, CHRISTINE MARIE;LONG, CYNTHIA R (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: Address;Adult;Age;Ambulatory Care;American College of Physicians;Biological Models;Caring;Categories;chiropracty;Chronic;chronic pain management;Clinical;collaboratory;comparative effectiveness;cost effective;design;Diagnosis;disability;Doctor of Chiropractic;dosage;Dose;Drug Prescriptions;Effectiveness;effectiveness evaluation;effectiveness study;evidence base;Expenditure;functional outcomes;functional restoration;health service use;Health Services;Hospitalization;Injections;Intervention;Intervention Studies;Knowledge;Life;Long term disability;Low Back Pain;Low Prevalence;Measures;Medical center;Methods;military veteran;multimodality;Musculoskeletal Diseases;Nonpharmacologic Therapy;Operative Surgical Procedures;Opiate Addiction;Opioid;Outcome;Pain;Pain intensity;Pain interference;pain outcome;pain patient;pain relief;pain-related disability;Participant;Patients;Pattern;Perception;Persons;Pharmaceutical Preparations;Phase;Physical therapy;Policies;pragmatic randomized trial;primary endpoint;primary outcome;process evaluation;Productivity;productivity loss;Provider;Quality of life;Questionnaires;Random Allocation;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Infrastructure;Research Personnel;response;Risk;Schedule;secondary outcome;Services;Site;Societies;Spinal Manipulation;System;systematic review;Therapy trial;treatment arm;treatment as usual;treatment duration;Treatment Factor;treatment group;trial enrollment;Uncertainty;Uninsured Medical Expense;United States National Institutes of Health;Veterans;Veterans Health Administration;Visit;Work

PROJECT_TITLE: Chiropractic Care for Veterans: A Pragmatic Randomized Trial Addressing Dose Effects for cLBP


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Kidney Disease;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE This mul)-PI research proposal uses data sets from a mouse model of human glomerular disease that was successfully “treated”, to deﬁne podocyte injury mechanisms at an early stage when human )ssue for inves)ga)on is inaccessible. Bioinforma)c comparison of the mouse and human data sets will be performed to iden)fy early mechanisms in glomerular disease to design eﬀec)ve treatments that can start as early as possible to minimize long-term kidney damage.

PI_NAMEs: CHANG, AUDREY N;MILLER, RICHARD TYLER (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Acceleration;Actins;Actomyosin;Adhesions;Adult;Architecture;Area;Back;Basement membrane;Behavior;Biological Models;Biology;Biopsy;Blood capillaries;Cell Line;Cells;Cellular Structures;chemokine;Chronic Kidney Failure;Clinical;clinically relevant;cohort;Collagen;Collagen Type IV;Creatinine;Cultured Cells;cytokine;Cytoskeleton;Data;Data Set;Databases;design;Development;Diagnostic tests;differential expression;Differentiation Antigens;Disease;disease phenotype;Early Diagnosis;Elasticity;End stage renal failure;Etiology;Event;Failure;Focal and Segmental Glomerulosclerosis;Foot Process;Genes;genetic regulatory protein;Glomerular Capillary;Goals;hemodynamics;Hereditary nephritis;Heterozygote;Human;human data;human disease;human model;human tissue;Hypertrophy;IGA Glomerulonephritis;Image;Immunofluorescence Microscopy;improved;in vivo;in vivo evaluation;Injury;Injury to Kidney;insight;interest;Intervention;Kidney;kidney biopsy;Kidney Diseases;Kidney Failure;kidney fibrosis;Knock-out;Maintenance;Maps;Mediating;Methods;migration;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Myosin Type II;Nature;nephrin;non-muscle myosin;novel;Orthologous Gene;paralogous gene;Pathologic;Pathway interactions;Patients;Pattern;Phenotype;podocyte;polymerization;Polymers;potential biomarker;Predisposition;Process;programs;Property;Protein Inhibition;Protein Kinase;Proteins;Proteinuria;Proteomics;Publishing;Regulation;renal damage;Renal function;Renal glomerular disease;Reporting;Research;Research Proposals;response;response to injury;Role;Signal Transduction;Stains;Structure;synaptopodin;tauroursodeoxycholic acid;Testing;therapeutic target;Thinness;Time;Tissues;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Early podocyte injury in collagen IV nephropathy

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

ORG_STATE: MA

PHR: PROJECT NARRATIVE We invented a novel optical device which provides more than 45° of image shift to be used by patients with homonymous hemianopia or peripheral field loss as a visual aid for field expansion. In a multi-center clinical trial, we will measure collision detection performance with the proposed device, which we expect to provide greater independence and improve quality of life.

PI_NAMEs: PELI, ELI  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Area;Automobile Driving;blind;Brain Injuries;Choroideremia;Clinic;Color;Computers;cost effective;design;Detection;detection test;Devices;effectiveness testing;efficacy study;expectation;Eye;falls;feasibility testing;Glaucoma;hazard;Homonymous Hemianopia;Image;improved;Individual;innovation;invention;Island;Measures;Multi-Institutional Clinical Trial;novel;Optics;Patients;Pentas;Performance;Peripheral;Positioning Attribute;preference;prototype;Quality of life;Randomized;Reporting;Residual state;Retinal Diseases;Retinitis Pigmentosa;Risk;Scanning;Side;Stroke;success;System;Testing;Trauma;tumor;virtual reality;Visual;Visual Aid;Visual Fields;Walking

PROJECT_TITLE: Visual Field Expansion Through Innovative Multi-periscopic Prism Design (AD)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Colorectal Cancer;Digestive Diseases;Genetics;Hepatitis;Human Genome;Liver Cancer;Liver Disease;Microbiome;Nanotechnology;Nutrition;Obesity;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE  This project develops and characterizes a nanodrug that was designed and synthesized based on the compromised bacteria-regulated signaling found in human liver and colon cancers. Likely through the activation of liver and intestinal bile acid receptors, which is also reduced in human liver and colon cancers, this new drug treats Western diet-induced fatty liver, insulin resistance, and inflammation. Characterization of this first-in-class medication impacts the treatment and prevention of metabolic liver diseases, where currently no FDA-approved medications are available.

PI_NAMEs: WAN, YU-JUI YVONNE (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Acids;Affect;Age;Agonist;Alkylation;amphiphilicity;Animal Experiments;Animal Model;Animals;Bacteria;Bile Acids;Bioinformatics;Biological Assay;Biological Availability;cancer cell;cancer therapy;Cell model;Chemicals;Collagen;Colon;colon cancer patients;Colon Carcinoma;Colorectal Cancer;Compensation;Consumption;Data;Data Analyses;Deacetylase;design;Development;Diet;diet-induced obesity;Dimerization;disorder prevention;Distress;Drug Design;drug discovery;Drug Kinetics;drug synthesis;Drug Targeting;Enzymes;Epigenetic Process;Epithelial Cells;esterase;Esters;Fatty Liver;FDA approved;Gastrointestinal tract structure;Genes;Genetic Transcription;Goals;good diet;gut dysbiosis;gut-liver axis;Harvest;Health;Hepatic;Histology;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;hydrophilicity;improved;Inflammation;Insulin Resistance;insulin sensitivity;Intestinal Absorption;Intestines;Knockout Mice;Link;Lipids;Liver;liver cancer patient;liver cancer prevention;Liver diseases;liver function;liver metabolism;Malignant neoplasm of liver;Malignant Neoplasms;Melilotus;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolic dysfunction;microbial;mouse model;Mus;nano;nanodrug;nanoformulation;nanomicelles;nanoparticle;new chemical entity;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obese Mice;Oral;Oral Characters;Outcome;Particle Size;Pathway interactions;Pharmaceutical Preparations;Pilot Projects;Polymers;Polyvinyl Alcohol;PPAR alpha;prevent;Prevention;Preventive;Primary carcinoma of the liver cells;Property;Propionic Acids;Proteins;Quality Control;receptor;Risk;RNA;RXR;Serum;Signal Induction;Signal Transduction;Solubility;Specimen;Splenomegaly;Steatohepatitis;success;System;Testing;Toxic effect;Toxicology;transcriptome sequencing;transcriptomic profiling;Tretinoin;Update;Volatile Fatty Acids;western diet;Wild Type Mouse;Work

PROJECT_TITLE: A Novel Nanodrug for Metabolic Disease Treatment


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PROJECT_TITLE: NIH Tetramer Core Facility (Influenza)


PROJECT_TITLE: NIH Tetramer Core Facility for Immunologic and Infectious Disease


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Substance Misuse

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: This supplement to the ABCD-USA Consortium: Data Analysis and Informatics Resource Center (DAIRC) funds ongoing efforts to develop a new infrastructure for data releases for the Adolescent Brain Cognitive Development (ABCD) Study. The goal is to have the infrastructure set up in time for the 6.0 data release scheduled for Fall 2024 and to use this infrastructure for all data releases going forward.

PI_NAMEs: DALE, ANDERS M (contact)

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: Administrative Supplement;Adolescence;Adolescent;Adolescent Development;Brain;Child;cognitive development;Contractor;Data;Data Analyses;Data Analytics;data and analysis portal;data exploration;data infrastructure;data ingestion;data integration;data management;data sharing;Database Management Systems;Databases;Development;Emotional;experience;falls;Fentanyl;Funding;Future;Genomics;Goals;Grant;Growth;improved;Informatics;Infrastructure;large datasets;Metadata;migration;neuroimaging;Opioid;Positioning Attribute;Process;Resource Informatics;Resources;Schedule;Security;Security Measures;Shapes;social;Standardization;Statistical Data Interpretation;System;Time;United States National Institutes of Health;Visualization

PROJECT_TITLE: ABCD-USA Consortium: Data Analysis, Informatics and Resource Center


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: HANOVER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Defects in the mitotic entry control system can lead to genomic instability, a hallmark of cancer, and cell shape changes are associated with multiple stages of cancer progression including metastasis. We will use the model organism fission yeast to define of the upstream signals that govern mitotic entry and polarized growth in eukaryotes. These findings will be important to understand the cellular mechanisms that prevent untimely and inappropriate cell divisions, which contribute to human diseases such as cancer.

PI_NAMEs: MOSELEY, JAMES B (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Area;Biochemical;Biological Models;biological systems;CDC2 gene;Cell Cycle;Cell division;cell growth;Cell Nucleus;Cell Polarity;Cell Shape;Cell Size;Cells;Cyclin-Dependent Kinases;Cyclins;Cytoplasmic Granules;Defect;design;Eukaryota;Eukaryotic Cell;Fission Yeast;Fluorescence Microscopy;Funding;Future;Genetic;Genetic Screening;Genomic Instability;Goals;Growth;human disease;interdisciplinary approach;Knowledge;live cell microscopy;Malignant Neoplasms;Mammals;mathematical model;Mitosis;Mitotic;model organism;Molecular;Monitor;mutant;National Institute of General Medical Sciences;Neoplasm Metastasis;novel;Organism;particle;Pathway interactions;Pattern;phosphoproteomics;Positioning Attribute;prevent;Process;Protein Kinase;Proteins;reconstitution;Regulation of Cell Size;Reproducibility;Research;RNA;Rod;Role;Shapes;Signal Transduction;simulation;SNAP receptor;Surface;System;therapeutic target;tumor progression;Work;Yeasts

PROJECT_TITLE: Mechanisms controlling cell size and shape

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: ALBUQUERQUE

ORG_NAME: AMERICAN INDIAN SCIENCE/ENGNRNG SOCIETY

ORG_STATE: NM

PI_NAMEs: DEERINWATER, KATHY  (contact)

PROGRAM_OFFICER_NAME: CERRONE, CAROLINA AGUIAR

PROJECT_TERMS: Acceleration;Address;Ally;American Indians;Awareness;Belief;career;Case Study;cohort;Collaborations;Communication;Communities;curriculum development;Data Science;Databases;Development;Education and Outreach;Educational Curriculum;Educational process of instructing;Educational workshop;Elements;Engineering;Event;experience;Faculty;Feeds;field study;Funding;Future;Goals;Growth;Health;Health Promotion;Health Sciences;higher education;Indigenous;indigenous community;Individual;Institution;interest;Internet;Knowledge;Learning;learning network;lens;Link;Media Campaign;Medical;member;Movement;Multimedia;Music;Native Americans;Online Systems;outreach;Participant;Pathway interactions;patient engagement;Persons;phenomenological models;Population Heterogeneity;Positioning Attribute;Precision Health;precision medicine;Printing;recruit;Research;Research Personnel;Resources;Schools;Science;science education;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Scientist;Societies;Speed;STEM research;Strategic Planning;Students;success;symposium;System;teacher;teacher community;Technology;Thinking;tool;Transcend;tribal college;tribal organization;Tribes;Typology;university student;virtual;Water;webinar;Work;young adult;Youth

PROJECT_TITLE: We Are All Scientists - promotes precision medicine and health research in Indigenous communities through a large scale multimedia campaign and building of strategic partnerships with schools and TCUs


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Chronic kidney disease affects 37 million people in the U.S. and, due to limited treatment options, often progresses to kidney failure. This project aims to elucidate how disrupted iron metabolism in CKD patients impacts the key cells involved in disease progression: proximal tubular epithelial cells. The proposed studies will focus on the effects of iron on the injury and survival of these cells and will identify strategies to slow disease progression by targeting kidney iron metabolism.

PI_NAMEs: AKCHURIN, OLEH  (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Accounting;Address;Adenine;Affect;American;Anemia;Biological Markers;Cell Culture Techniques;Cell Death;Cell Separation;Cell Survival;Cells;Ceruloplasmin;Cessation of life;chelation;Chronic Kidney Failure;Coupled;Critical Pathways;Cytoprotection;Data;Development;Dialysis procedure;Disease Progression;Dissociation;effective therapy;Enzymes;Epithelial Cells;Excision;experimental study;Ferritin;Fibrosis;Flow Cytometry;Fluorescent Probes;Functional disorder;Goals;H ferritin;Hereditary nephritis;Homeostasis;improved;in vivo;Injury;insight;Iron;Iron Chelating Agents;Iron Chelation;iron metabolism;Iron Overload;iron supplementation;Iron-Dextran Complex;Kidney;kidney biopsy;Kidney Diseases;Kidney Failure;kidney fibrosis;Kidney Transplantation;Knock-out;Knockout Mice;Knowledge;Macrophage;metal transporting protein 1;Modeling;mouse model;Mus;Mutant Strains Mice;new therapeutic target;novel;novel therapeutic intervention;Oxidation-Reduction;Pathway interactions;Patients;Persons;Population;prevent;Proteins;Protocols documentation;Regulation;Renal tubule structure;response;Role;Techniques;Testing;Therapeutic;therapeutic target;Tissues;Toxic effect;Tubular formation;Ureteral obstruction;Work

PROJECT_TITLE: Mechanisms of intracellular iron dysregulation in kidney fibrosis and reno-protective strategies


FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Physical Injury - Accidents and Adverse Effects

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PROJECT_TERMS: Address;Agreement;Area;Binding;biodefense;Biological Models;Collaborations;Communicable Diseases;Diagnostic;Effectiveness;Elements;Health Hazards;Ingestion;Injury;interest;Intestines;Liquid substance;Metals;Military Personnel;National Institute of Allergy and Infectious Disease;Nuclear;nuclear countermeasure;programs;public health emergency;radiation countermeasure;Radiation exposure;Radiobiology;Radiology Specialty;Research;research and development;Rodent Model;United States National Institutes of Health;water solution

PROJECT_TITLE: Advancement of Cs-MIP as a promising decorporation agent


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

PHR: Project Narrative Regulatory T cells (Tregs) are one of the main immune components that control autoimmune disease and are selectively disrupted in the setting of Interleukin-2 (IL-2) signaling deficiencies. Numerous studies are examining the therapeutic potential of low-dose IL-2, but these evaluations would benefit by a more complete knowledge concerning the mechanisms by which IL-2 effects mature Tregs. This study will address fundamental questions surrounding the contribution of IL-2 receptor signaling for Treg survival, differentiation, and function to aid in the therapeutic application of this cytokine and to better define potential targets related to IL-2/IL-2 receptor genetic risk for autoimmunity.

PI_NAMEs: SHOUSE, ACACIA NICOLE (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Ablation;Acute;Adoptive Transfer;Adrenal Cortex Hormones;Affect;American;Animals;Apoptosis;ATAC-seq;Autoimmune Diseases;Autoimmunity;autoreactive T cell;Bioinformatics;Biological Assay;Biology;Bypass;Cause of Death;Cell Physiology;Cell Survival;Cellular biology;Complex;Complication;cytokine;Data;Defect;Development;Disease;Dose;Drops;Epigenetic Process;Evaluation;Exhibits;experience;Fellowship;Flow Cytometry;Gene Modified;Genetic Risk;Genetic Transcription;Heterogeneity;Homeostasis;Human;IL2RA gene;Immune;improved;in vitro Assay;in vivo;Incidence;Inflammatory;Insulin-Dependent Diabetes Mellitus;Interleukin 2 Receptor;Interleukin-2;Investigation;Knock-out;Knockout Mice;Knowledge;Lead;Lupus;Malignant Neoplasms;Manipulative Therapies;Measures;Mediating;Memory;Metabolism;Midlife women;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Pathway interactions;Peripheral;peripheral tolerance;Play;Population;Positioning Attribute;Predisposition;Prevention;Process;Proliferating;Receptor Signaling;Recombinant Interleukin-2;Regulatory T-Lymphocyte;Research;Role;Self Tolerance;side effect;Signal Transduction;single-cell RNA sequencing;Sorting;T cell differentiation;T-Lymphocyte Subsets;Techniques;Therapeutic;tool;Training;Transcription Process;transcriptome sequencing

PROJECT_TITLE: Mechanisms of regulatory T cell processes by IL-2" - TRANSFER to UNM


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PI_NAMEs: FERNANDEZ, MARIA EULALIA (contact)

PROGRAM_OFFICER_NAME: PARASCANDOLA, MARK

PROJECT_TERMS: Accountability;Address;Area;California;cancer care;Cancer Control;cohesion;Collaborations;Communication;community engagement;Community Health;Complex;Decision Making;Disparity;Ensure;Equity;experience;Goals;health organization;Health Sciences;Health system;HPV screening;implementation evaluation;implementation science;Infrastructure;insight;Institution;Intervention;Knowledge;Laboratories;Latin America;Latin American;Lead;Leadership;Learning;low and middle-income countries;Malignant Neoplasms;Mentorship;Mexican;Mexican Americans;Mexico;Mission;National Cancer Institute;operation;Pilot Projects;Policy Maker;Process;programs;Public Health;Readiness;Research;Research Activity;Research Project Grants;Research Support;Resources;Role;Sampling;San Francisco;Social Security;Strategic Planning;success;Texas;United States;Universities;Vertebral column;Work;Workplace

PROJECT_TITLE: Administrative and Engagement Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health

PI_NAMEs: DUNCAN, DOMINIQUE ;POURATIAN, NADER  (contact)

PROGRAM_OFFICER_NAME: ZHAN, MING


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Antibody-based therapeutics that target the HER2 oncoprotein, such as trastuzumab, have had a transformative  impact on the survival of patients with HER2-positive breast cancer. Nevertheless, many patients develop  resistance to this form of targeted therapy, in some cases through the upregulation of a truncated form of HER2  (termed p95HER2) that lacks the epitopes recognized by these therapeutic antibodies. This project will elucidate  the impact of p95HER2 on the tumor immune microenvironment and evaluate potential new strategies for  treating p95HER2-positive breast cancers.

PI_NAMEs: LUCAS, PETER C (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Affect;anti-cancer research;Antibody Therapy;Automobile Driving;Breast Cancer Cell;Cancer Etiology;cancer invasiveness;Clinic;Clinical;Combined Modality Therapy;design;Development;Diagnostic tests;Disease;Epitopes;ERBB2 gene;Extracellular Domain;Gene Amplification;Goals;Human;Immune response;Immunosuppression;improved;innovation;insight;Length;Malignant Breast Neoplasm;Malignant Neoplasms;Messenger RNA;Molecular;Mutation;neoplastic cell;novel strategies;Oncogenic;Oncoproteins;Patients;Pertuzumab;Production;prognostic assays;Property;Proteins;Recurrence;Refractory;refractory cancer;Research Project Grants;Resistance;Resistance development;Signal Pathway;Signal Transduction;Site;targeted treatment;Testing;Therapeutic;Therapeutic antibodies;Therapeutic Monoclonal Antibodies;therapeutic target;therapy development;therapy resistant;Time;Translation Initiation;Trastuzumab;treatment response;tumor;Tumor Immunity;Tumor Markers;tumor microenvironment;tumor-immune system interactions;Up-Regulation;Variant;Woman;Women's mortality;Work

PROJECT_TITLE: Project 4


FUNDING_MECHANISM: SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: COLLEGE STATION

ORG_NAME: LYNNTECH, INC.

PI_NAMEs: HARLOW, MARK LEE (contact)

PROJECT_TERMS: Algorithms;Antibodies;Bispecific Antibodies;Businesses;Complex;Contracts;Development;Device or Instrument Development;Devices;Drug Kinetics;Engineering;Formulation;Goals;Half-Life;HIV-1;Infection;Injections;manufacture;Mediating;Methods;National Institute of Allergy and Infectious Disease;neutralizing antibody;next generation;Prevention trial;programs;RNA;Sarna;Structure;success;Testing;Tissues

PROJECT_TITLE: coRNAucopia - A Method to Deliver Multiple bNAbs in the Same RNA


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: AMES

ORG_NAME: NEOVAXSYN, INC.

PI_NAMEs: RAYCHAUDHURI, SANTANU  (contact)

PROJECT_TERMS: Antibodies;Bispecific Antibodies;Businesses;Complex;Contracts;controlled release;Development;Device or Instrument Development;Devices;Drug Kinetics;Engineering;Environment;Female;Film;Formulation;Goals;Half-Life;HIV-1;Immunoprevention;Infection;Injections;Kinetics;manufacture;Mediating;National Institute of Allergy and Infectious Disease;neutralizing antibody;next generation;novel;Polymers;Prevention trial;programs;success;Tissues;Vagina

PROJECT_TITLE: Development of a Next-Generation Immunoprevention Platform Against HIV-1


ORG_CITY: CAMBRIDGE

ORG_NAME: ACOUSTICABIO, INC.

PI_NAMEs: FORESTI, DANIELE  (contact)

PROJECT_TERMS: Antibodies;Biological Availability;Bispecific Antibodies;Businesses;Complex;Contracts;Cyclodextrins;design;Development;Device or Instrument Development;Devices;Dose;Drug Kinetics;Engineering;Formulation;Goals;Half-Life;HIV-1;Hydrogels;in vivo;Infection;Injections;manufacture;Mediating;National Institute of Allergy and Infectious Disease;neutralizing antibody;next generation;particle;Prevention trial;Printing;programs;prototype;Subcutaneous Injections;success;System;Tissues

PROJECT_TITLE: High-Dose and Sustained Delivery of HIV-1 Broadly Neutralizing Antibodies via Subcutaneous Injection of Hydrogel-based Microparticle Formations


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NEWTON CENTER

ORG_NAME: CURE SYSTEMS LLC

PI_NAMEs: MILLER, JACQUELINE  (contact)

PROJECT_TERMS: Antibodies;Bispecific Antibodies;Businesses;Complex;Contracts;Development;Device or Instrument Development;Devices;Drug Kinetics;Engineering;Formulation;Goals;Half-Life;HIV;HIV-1;in vivo;Infection;Injections;manufacture;Mediating;National Institute of Allergy and Infectious Disease;neutralizing antibody;next generation;Prevention trial;programs;success;Tissues;vector

PROJECT_TITLE: Vector-Based Delivery of HIV Broadly Neutralizing Antibodies


NIH_SPENDING_CATS: HIV/AIDS

PROJECT_TITLE: Technical Support Services for Division of AIDS Learning Management System (LMS)


NIH_SPENDING_CATS: Cancer;Pediatric

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PI_NAMEs: CALIFANO, ANDREA  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Administrator;Advisory Committees;analytical tool;Award;Biomedical Research;Budgets;Calibration;Cancer Center;Cities;Collaborations;Collection;Committee Members;Communication;Communities;Complex;Computer software;Consultations;Data;data harmonization;Data Set;data sharing;data submission;Decision Making;diversity and inclusion;Education;Educational workshop;Elements;Ensure;Environment;Evaluation;Feedback;Fostering;Funding;Funding Opportunities;Future;Grant;Guidelines;High Performance Computing;high school;Human Resources;Individual;Knowledge;Leadership;Learning;Logistics;Maintenance;Malignant Neoplasms;meetings;member;Minority-Serving Institution;Monitor;New York City;operation;Organization administrative structures;outreach;Persons;Pilot Projects;Policies;Preparation;Procedures;Process;programs;Progress Reports;Qualifying;recruit;repository;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resource Sharing;Resources;Services;Shapes;Site Visit;Structure;success;synergism;System;Systems Biology;Technology;Teleconferences;Therapeutic;United States National Institutes of Health;university student;web site;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Cancer;Colorectal Cancer;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Rare Diseases

PI_NAMEs: HONIG, BARRY H (contact)

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;analytical tool;Automobile Driving;Behavior;Binding;Biological Assay;Biomedical Engineering;cancer cell;Cancer Center;Cell Line;Cells;clinically relevant;Colon Adenocarcinoma;Colonic Neoplasms;Communities;Complex;Coupled;Data;deep learning;deep learning algorithm;Dependence;Development;Dissection;Drug resistance;drug sensitivity;Environment;extracellular;Foundations;Funding;Gene Expression Profile;Generations;Genetic Transcription;Goals;Human;improved;in vivo;Individual;individual variation;innovation;intercellular communication;Investigation;Knowledge;Language;Ligands;Malignant - descriptor;Malignant Neoplasms;Maps;Mediating;Methodology;Modeling;Molecular;multiple omics;Natural Language Processing;Nature;neoplastic cell;network models;Network-based;Normal Cell;novel;Oncoproteins;Organ;organ on a chip;Pancreatic Ductal Adenocarcinoma;paracrine;Paracrine Communication;Peptides;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphoproteins;phosphoproteomics;Physiology;Printing;Process;protein protein interaction;protein structure;Proteins;Proteome;Publications;Reagent;receptor;recruit;Research;Research Personnel;response;Reverse engineering;Scientist;Signal Transduction;small molecule;small molecule inhibitor;Stromal Cells;Structure;System;Techniques;Technology;technology validation;Therapeutic;therapeutic target;three dimensional structure;Time;Tissues;tumor;tumor microenvironment;tumorigenic;Validation;Work

PROJECT_TITLE: Structure-informed dissection of cancer-specific intracellular and paracrine networks


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Precision Medicine

PI_NAMEs: IZAR, BENJAMIN  (contact)

PROJECT_TERMS: actionable mutation;Address;analytical tool;Behavior;Binding;Biological;Biology;Brain;Brain Neoplasms;cancer cell;Cancer Center;cancer heterogeneity;Cancer Patient;cell behavior;Cell Communication;Cells;Cephalic;checkpoint therapy;Chronology;Clinical;clinically relevant;Complex;computerized tools;Coupled;Cues;Cutaneous Melanoma;Data;Dedications;Dependence;design;Disease;Disease Progression;Dissection;Drug resistance;Drug Screening;Ecosystem;Event;Fostering;Future;Gene Expression Profiling;Genetic Transcription;Genome;genome editing;genome sequencing;Genomics;Goals;Heterogeneity;Human;human model;immune checkpoint blockade;Immune checkpoint inhibitor;Immunosuppression;Immunotherapy;improved;In Situ;in vivo;innovation;insight;Label;Ligands;Link;Logic;machine learning framework;Malignant - descriptor;Malignant Neoplasms;malignant state;Mediating;Metastatic malignant neoplasm to brain;Methods;Minority;Modeling;Molecular;multimodal modeling;multimodality;multiple omics;Neoplasm Metastasis;Network-based;Non-Small-Cell Lung Carcinoma;novel;paracrine;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Primary Neoplasm;Printing;Process;programs;Proteins;Publications;receptor;recruit;Research Personnel;Resistance;Resolution;response;Series;Signal Transduction;single cell genomics;Site;Slice;Somatic Mutation;spatiotemporal;Stratification;System;targeted treatment;Testing;Therapeutic;therapeutic development;Time;Tissues;tool;transcriptomics;treatment response;tumor;tumor microenvironment;tumor progression;tumor-immune system interactions;tumorigenic;Validation;whole genome

PROJECT_TITLE: Single-Cell, Spatial and Functional Dissection of Cancer Cell States, Co-Evolving Ecosystems, and Vulnerabilities During Tumor Progression and Metastasis


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Precision Medicine;Prostate Cancer;Rare Diseases;Urologic Diseases

PROJECT_TERMS: actionable mutation;Address;Algorithms;androgen independent prostate cancer;Behavior;cancer cell;Cancer Center;Cancer Patient;cell behavior;Cell Line;Cell model;Cells;Clinical;clinically relevant;Complement 1q;Complex;Data;Dependence;design;Disease-Free Survival;drug mechanism;Drug resistance;drug sensitivity;Drug Targeting;drug-sensitive;Duct (organ) structure;Excision;Fibroblasts;Fostering;Funding;Genetically Engineered Mouse;genome database;genome-wide;Goals;Health;Heterogeneity;Human;human model;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immunotherapy;improved;In Vitro;in vivo Model;Individual;Infiltration;Inter-tumoral heterogeneity;Intervention;Isogenic transplantation;KPC model;Logic;Macrophage;Malignant - descriptor;Malignant Neoplasms;MAP Kinase Gene;Mediating;Metaplasia;Methodology;Modeling;Molecular;neoplastic cell;Network-based;Neurosecretory Systems;novel;Organoids;Outcome;panacea;Pancreatic Ductal Adenocarcinoma;Paracrine Communication;Pathway interactions;patient derived xenograft model;patient responsibilities;Patients;Pharmaceutical Preparations;pharmacologic;Pre-Clinical Model;Prediction of Response to Therapy;Printing;programs;Proteins;Proteome;Publications;Reagent;recruit;Regulatory T-Lymphocyte;Relapse;relapse patients;response;Sampling;single cell analysis;small molecule inhibitor;System;targeted treatment;Therapeutic;TREM2 gene;tumor;tumor heterogeneity;tumor microenvironment;tumor-immune system interactions;Validation;virtual

PROJECT_TITLE: Drug Mechanism of Action-based targeting of tumor subpopulations


NIH_SPENDING_CATS: Cancer

PI_NAMEs: MURRAY, DIANA  (contact)

PROJECT_TERMS: Achievement;Adoption;anti-cancer research;artist;Belief;Cancer Center;cancer diagnosis;career;Case Study;Collaborations;college;Communities;community building;Community Outreach;computer infrastructure;Computer software;Creativeness;Data;design;Development;diversity and inclusion;Education;Education and Outreach;Educational workshop;Effectiveness;Ensure;Environment;Equity;equity, diversity, and inclusion;Ethnic Origin;Exclusion;experience;Faculty;forging;formative assessment;Fostering;Foundations;Future;Goals;Graduate Education;high school;High School Student;Institution;instructor;Language;Learning;Malignant Neoplasms;member;Mentors;Mission;Monitor;multidisciplinary;next generation;novel;Online Systems;outreach;Palpable;Participant;Persons;Postdoctoral Fellow;Productivity;programs;Publications;Race;Research;Research Personnel;residence;Residencies;Resource Sharing;Resources;Role;Scholars Program;Science;Scientist;skills;STEM field;Student recruitment;Students;success;Surveys;System;Systems Biology;Technology;Therapeutic;Therapeutic Research;tool;Training;Translating;Underrepresented Populations;Universities;Visual;Work;working group

PROJECT_TITLE: Outreach Core


PI_NAMEs: SIMS, PETER ALAN (contact)

PROJECT_TERMS: Address;analytical method;Apoptosis;ATAC-seq;Bar Codes;Cancer Center;Cell Communication;Cell Death;Cell model;Cell Survival;cell type;Cells;cellular imaging;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Computer Models;CRISPR interference;Cytometry;droplet sequencing;Epitopes;experimental analysis;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Pool;Genomic Library;Genomics;Goals;Guide RNA;Human;Image;Immunofluorescence Immunologic;In Situ;Individual;Joints;Libraries;Link;live cell imaging;Malignant Neoplasms;Messenger RNA;Methods;microfluidic technology;Microfluidics;Molecular;Molecular Analysis;Molecular Target;multiple omics;Mus;Periodicity;Pharmaceutical Preparations;posttranscriptional;Preparation;Proteins;Proteomics;Protocols documentation;Quality Control;Research Personnel;Resolution;response;RNA;Sampling;single cell analysis;single cell ATAC-seq;single cell genomics;single cell technology;single-cell RNA sequencing;Slice;Solid Neoplasm;System;technological innovation;Technology;Therapeutic;Tissues;tool;Transcript;transcriptome sequencing;tumor;tumor microenvironment;Validation

PROJECT_TITLE: Advanced Single Cell Technology Innovation Core


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative: The deregulation of autophagy and heightened inflammation has been implicated in dry age-related macular degeneration (AMD). This proposal will use a novel mouse model and human iPSC-derived RPE cells from controls and AMD risk allele containing donors to decipher a yet unknown role of the crosstalk between the autophagy and inflammatory processes in the pathogenesis of dry AMD. We envisage that the proposed studies will help to develop strategies, potentially leading to novel therapies for this disease, which has no treatment available at the moment.

PI_NAMEs: GHOSH, SAYAN  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Acetylcysteine;Address;Adhesions;Affect;Age related macular degeneration;aged;aging related disease;Animal Model;Antioxidants;Automobile Driving;Autophagocytosis;Biochemical;bioinformatics tool;Biological Assay;Blindness;Cell Communication;Cells;Cellular Assay;Choroid;Chronic;cytokine;Data;Deposition;Disease;Dryness;Elderly;Environmental Risk Factor;experimental study;Eye diseases;ezrin;Flow Cytometry;Functional disorder;Genetic;Health;Histology;Homeostasis;Homing;Human;human induced pluripotent stem cells;Hyperpigmentation;Immune;Immune system;immunological status;Immunophenotyping;Impairment;in vivo;Individual;induced pluripotent stem cell;Infiltration;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Intravenous;Knock-in;Knock-in Mouse;Laser Scanning Confocal Microscopy;Lead;macula;Mediating;Mentors;Messenger RNA;Microglia;Mitochondria;Modality;Molecular;monocyte;Morphology;mouse model;Mus;neutrophil;NOD/SCID mouse;Nonexudative age-related macular degeneration;novel;novel therapeutics;overexpression;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Pathway interactions;Patients;Phagocytosis;Phase;Phenotype;Play;Population;Process;Property;Regulation;Reporting;Research;Retina;Retinal Degeneration;risk variant;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Stimulator of Interferon Genes;Structure of retinal pigment epithelium;Testing;Tissues;tool;Training;Up-Regulation;Vision

PROJECT_TITLE: Deciphering the role of mitochondrial/autophagy dysfunction in regulating inflammatory processes during AMD pathogenesis


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Biomedical Imaging;Childhood Obesity;Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Obesity;Pediatric;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE Dysanapsis, the mismatch between airway tree and lung size, is a common structural variation in the lung that is a better predictor of chronic obstructive pulmonary disease than smoking and all previously described risk factors. In this R01 study, our objective is to examine the relationship between early-life exposures and both structural (lung MRI-assessed) and functional (spirometry-assessed) measures of dysanapsis throughout childhood and adolescence. We will leverage 8 longitudinal birth cohorts of diverse children to identify modifiable risk factors for dysanapsis and help reduce risk of COPD in future generations at risk.

PI_NAMEs: LOVINSKY-DESIR, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Accounting;Adolescence;Adolescent;Age;Air Pollution;ambient air pollution;Asthma;Biogenesis;Birth;Caliber;Cessation of life;Child;Childhood;Childhood Asthma;Chronic Obstructive Pulmonary Disease;cohort;Data;disorder risk;early childhood;early life exposure;Environment;Ethnic Origin;Exposure to;fine particles;Future;Future Generations;Genetic;Growth;health difference;high risk population;Image;Intervention;Life;Low income;Lung;lung volume;Magnetic Resonance Imaging;Measures;modifiable risk;Modification;National Heart, Lung, and Blood Institute;Neighborhoods;Nitrogen Dioxide;Obesity;obesity in children;older adult;Organism;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;Pollution;Population;Poverty;Prevention;prospective;pulmonary function;Race;radiological imaging;recruit;Research;respiratory;Respiratory Tract Infections;response;Risk;Risk Factors;Risk Reduction;Sampling;segregation;Smoking;social;Social Conditions;social factors;Spirometry;Tobacco smoke;treatment response;Trees;Urban Community;urban setting;Variant;Viral;Viral Respiratory Tract Infection;Virus Diseases;Work;X-Ray Computed Tomography;young adult

PROJECT_TITLE: Early Life Predictors of Airway to Lung Dysanapsis

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE An estimated 7 million stroke survivors are living in the United States. More than two-thirds of these have residual paralysis of the upper limb, and of them, ~37%-65% have moderate-to-severe paralysis. Few treatment options are appropriate or effective for these patients. Here, we will test whether combining a unique rehabilitation therapy of brain and nerve stimulation improves hand movement after moderate-to-severe stroke.

PI_NAMEs: SETHI, AMIT  (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TITLE: Strengthening task specific activation of paretic hand muscles after moderateto- severe chronic stroke

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Driving lymphoid potential in multipotent hematopoietic progenitors by linker histones Narrative This proposal aims to define a molecular pathway that regulates the lineage output of multipotent HSPCs by linker histones. The genomic targets of linker histones in HSPCs will be determined. We will also test whether protease inhibitors that can increase linker histone proteins can boost hematopoietic differentiation toward the lymphoid lineages.

PI_NAMEs: GUO, SHANGQIN  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Aspartic Endopeptidases;Automobile Driving;Binding;Biology;Cell Lineage;cell type;Cells;Chimeric Proteins;Chromatin;Chronic;Circulation;Collaborations;Common Lymphoid Progenitor;Data;Disease;DNA;Doxycycline;Drops;Fluorescence;Functional impairment;gain of function;Gene Expression;Genes;Genomics;Hematopoietic;hematopoietic differentiation;hematopoietic stem cell fate;Hematopoietic stem cells;Hepatic;Histones;HIV Protease Inhibitors;In Vitro;in vivo;Inflammation;Injury;insight;Interferons;Intervention;Knock-out;Knockout Mice;Letters;leukemia;loss of function;lymphocyte proliferation;Lymphoid;Lymphoid Cell;Lymphopoiesis;Malignant Neoplasms;Mature Lymphocyte;Mediating;Modeling;Molecular;mouse model;mRNA Expression;Multipotent Stem Cells;Mus;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;Myelopoiesis;Myeloproliferation;novel;Nucleosome Core Particle;Nucleosomes;Null Lymphocytes;Output;overexpression;Pathway interactions;Peptide Hydrolases;Phenotype;Physiological;posttranscriptional;preservation;prevent;Process;progenitor;Protease Inhibitor;protein degradation;Protein Isoforms;Proteins;Publishing;Research Personnel;response;Specific qualifier value;Specificity;Testing;Therapeutic;tool;transcription factor;transgene expression;Transgenes;Transgenic Mice

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Services;Mental Health;Mental Illness

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PI_NAMEs: CRASKE, MICHELLE G (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Administrator;Advocate;Anxiety;anxiety reduction;anxiety treatment;Award;California;care systems;career;Clinical;Clinical Research;Clinical Services;Collaborations;Communication;Communities;community college;Consult;Data;Decision Making;Effectiveness;Ensure;Environment;Ethics;ethnic diversity;Evaluation;experience;Faculty;Feedback;Funding;Future;Goals;Grant;Health Resources;healthcare community;Human Resources;human subject protection;Human Subject Research;implementation barriers;Improve Access;improved;Infrastructure;innovation;Intervention;Leadership;Life;Manuscripts;Marketing;meetings;Mental Depression;Mental Health;Mental Health Services;Mentors;Mentorship;Methods;Mission;multidisciplinary;next generation;operation;Pilot Projects;Preparation;programs;Provider;Publications;racial diversity;Research;research data dissemination;Research Ethics;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;Rice;Risk;Role;Scientist;screening;Self-Injurious Behavior;Services;social media;Solid;Structure;Students;Suicide;symposium;timeline;Training;university student;Vision;web platform;web site;Work

PROJECT_TITLE: Admin Core


ACTIVITY: ZIA

ADMINISTERING_IC: AR

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Human Genome;Wound Healing and Care

PI_NAMEs: MORASSO, MARIA  (contact)

PROJECT_TERMS: Animal Model;Architecture;ATAC-seq;Basal Cell;Basement membrane;Binding;Biopsy;Cell Cycle Progression;Cell Differentiation process;cell motility;Cell Physiology;Cells;Chromatin;chromatin immunoprecipitation;combinatorial;comparative;Complex;Cutaneous;Data Set;Development;Diabetic Foot Ulcer;differential expression;Elements;Epidermis;Epigenetic Process;epigenomics;Epithelial Cells;epithelial wound;Expression Profiling;FOXM1 gene;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;healing;Hi-C;histone modification;Homeobox;Human;Hyperglycemia;Hyperplasia;improved;in vivo;Inflammatory Response;keratinocyte;Modeling;Molecular;Molecular Profiling;Morphology;mouse model;Movement;Mus;neutrophil;Neutrophil Infiltration;Oral;Oral mucous membrane structure;Pathway interactions;Patients;Process;programs;Regulation;repaired;Research;Role;Signal Pathway;Signal Transduction;Site;Skin;skin barrier;Skin wound healing;Structure;Surface;therapeutic target;transcription factor;transcriptome sequencing;transcriptomics;Transgenic Mice;tumorigenesis;Up-Regulation;wound;wound healing

PROJECT_TITLE: Regulation Of Epidermal Differentiation


NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cardiovascular;Diabetes;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Relevance: Coronary microvascular dysfunction is associated with coronary artery diseases, diabetic cardiomyopathy, and HFpEF (heart failure with preserved ejection fraction). The current proposal is to study the underlying mechanism of a switch of mediator in endothelial-dependent vasodilation from NO to H2O2 in a pre-clinical diabetic model characterized by coronary microvascular dysfunction and how miR-21 regulates the switch and its consequence in myocardial blood flow in diabetic cardiomyopathy. We will establish novel therapeutic strategies to restore coronary microvascular function and stop the progress of diabetic cardiomyopathy.

PI_NAMEs: YIN, LIYA  (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: 3-Dimensional;Ablation;Acetylcholine;Adult;Anti-Inflammatory Agents;Antioxidants;arteriole;Biology;Blood flow;Blood Vessels;Bone Marrow Cells;Cardiac;Cardiovascular Pathology;Cardiovascular system;Cells;Clinical;Consensus;Contrast Echocardiography;Coronary;Coronary Arteriosclerosis;Coronary artery;Data;Development;Diabetes Mellitus;diabetic;diabetic cardiomyopathy;Diabetic mouse;diabetic patient;Diet;Discipline;Disease;Disease Progression;Echocardiography;EFRAC;endothelial dysfunction;endothelial stem cell;Endothelium;Endothelium-Dependent Relaxing Factors;Exhibits;Failure;fluorescence imaging;Functional disorder;Genetic;Heart failure;heart function;Hydrogen Peroxide;Hypertension;Impairment;improved;in vivo;Inflammatory;Injury;insight;interdisciplinary approach;Ischemia;Knock-out;Knockout Mice;Measurement;Mediating;Mediator;Methods;Microcirculation;MicroRNAs;Microvascular Dysfunction;Modeling;Molecular;mortality;Mus;Myocardial;Myocardial Ischemia;Myocardial perfusion;Myocardium;Nitric Oxide;novel;novel therapeutic intervention;Oxidative Stress;Pathogenicity;Pathology;Patients;Perfusion;Peroxisome Proliferator-Activated Receptors;pharmacologic;Physiologic pulse;Physiology;pre-clinical;preservation;prevent;Production;Prognosis;Reactive Oxygen Species;Relaxation;Reporting;restoration;Role;self-renewal;Stem cell transplant;Testing;Therapeutic;thrombotic;Tissues;transcriptome sequencing;Vasodilation;Vasodilator Agents

PROJECT_TITLE: Insights into Coronary Microvascular Dysfunction in Diabetic Cardiomyopathy

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PI_NAMEs: WU, XIAO-CHENG  (contact)

PROJECT_TITLE: SEER-LINKED VIRTUAL TISSUE REPOSITORY (VTR) PROGRAM


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PI_NAMEs: TUCKER, THOMAS  (contact)


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

PI_NAMEs: DUNN, MARSHA  (contact)

PROJECT_TERMS: annotation  system;Cancer Control;cancer statistics;Cancer Surveillance Research Program;case finding;Code;Contracts;Data;Data Collection;Data Linkages;data mining;data quality;Development;Division of Cancer Control and Population Sciences;Generations;Information Systems;Knowledge;Maintenance;Malignant Neoplasms;Methodology;Methods;novel;population based;Population Research;programs;Quality Control;Recommendation;Science;simulation;Statistical Models;statistics;Technology;Testing;tool;United States National Institutes of Health;usability;Visualization

PROJECT_TITLE: PROFESSIONAL SUPPORT FOR CANCER CONTROL AND POPULATION BASED RESEARCH NIH/NCI/DCCPS SURVEILLANCE RESEARCH PROGRAM


NIH_SPENDING_CATS: Neurosciences;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: BATTELLE CENTERS/PUB HLTH RES & EVALUATN

ORG_STATE: OH

PI_NAMEs: BURNAUGH, AMANDA  (contact)

PROJECT_TERMS: Appearance;Aspartylglucosaminuria;base;Biological Assay;Capsid;Dose;Endotoxins;Funding;Genetic;Genomics;Goals;manufacture;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;particle;Plasmids;Process;Qualifying;Sterility;Structure;Testing;Toxicology;U-Series Cooperative Agreements;vector;vector genome

PROJECT_TITLE: MANUFACTURING OF PLASMID AND VECTOR AND GLP DOSE-ESCALATION TOXICOLOGY STUDIES


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Prevention;Women's Health Research

ORG_CITY: SILVER SPRING

ORG_NAME: SOCIAL AND SCIENTIFIC SYSTEMS,  INC.

PI_NAMEs: SANDLER, DALE  (contact)

PROJECT_TERMS: abstracting;Address;Area;Biological;Breast Cancer Risk Factor;Cause of Death;Complement;Contractor;Data;Data Analyses;Data Security;Environmental Risk Factor;epidemiology study;follow-up;genetic risk factor;Geography;Health Status;Human;Information Systems;Medical Records;Pathologic;Physicians;Questionnaires;response;retention rate;Sampling;Sister;Statistical Data Interpretation;Update;Vital Status

PROJECT_TITLE: The Sister Study: Task Order 01 - Core Activities


NIH_SPENDING_CATS: Behavioral and Social Science;Contraception/Reproduction;HIV/AIDS;Obesity;Prevention;Women's Health Research

ORG_CITY: MORRISVILLE

ORG_NAME: HEALTH DECISIONS, INC.

ORG_STATE: NC

PI_NAMEs: ALLEN, ERIN  (contact)

PROJECT_TERMS: Age;Anti-HIV Agents;Clinical;Clinical Practice Guideline;Clinical Research;clinical research site;Clinical Trials;Companions;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Contractor;Contracts;Data;Desogestrel;Development;Devices;Drug Combinations;Drug Kinetics;Effectiveness;Enrollment;Equipment;Evaluation;follow-up;Formulation;Good Clinical Practice;Government;Government Agencies;Health Benefit;Hemorrhage;Human Resources;improved;Individual;Infection;International;Methods;Mission;Monitor;Multicenter Trials;National Institute of Child Health and Human Development;Nestorone;Non obese;Obesity;Pattern;Pharmaceutical Preparations;Population;Pregnancy;Prevention;Progestins;Protocols documentation;Public Health;Qualifying;Recording of previous events;Records;Regulation;Reporting;reproductive;Risk;Safety;Services;Site;symposium;Time;venous thromboembolism;Woman;Work

PROJECT_TITLE: CCTN - EVALUATION OF THE PHARMACOKINETIC PROFILE AND EFFECTS ON MECHANISMS OF CONTRACEPTION


NIH_SPENDING_CATS: Kidney Disease

ORG_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PROJECT_TERMS: Age;Agreement;Albumins;Albuminuria;Chemistry;Creatinine;Data Collection;Interview;Kidney;Kidney Diseases;National Health and Nutrition Examination Survey;Persons;Serum;Testing;Urine;urologic;Work

PROJECT_TITLE: National Health and Nutrition Examination Survey 2009-2010, Kidney component


NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: PENDLETON, RICHARD  (contact)

PROJECT_TITLE: FY23 TASK ORDER H - 126361 WEDGEWOOD SUITE M & N EXPANSION


NIH_SPENDING_CATS: Neurosciences

ORG_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PI_NAMEs: MCBAIN, CHRIS J. (contact)

PROJECT_TERMS: Action Potentials;Alzheimer's Disease;AMPA Receptors;Array tomography;autism spectrum disorder;Axon;Biochemical;Brain;Cell membrane;cell type;Cells;Cognition;cohort;Collaborations;comparative;Computer Models;Cyclic AMP;Cyclophosphamide;Data;Dendrites;dentate gyrus;Development;Disease;Drug abuse;Electron Microscopy;Electrophysiology (science);Elements;Ensure;Environment;Epilepsy;Exhibits;Experimental Animal Model;flexibility;Frequencies;Functional disorder;Generations;Genetic;Glutamates;granule cell;Hippocampus;Housing;Human;Image;innovation;interest;Interneuron function;Interneurons;Intramural Research Program;Ischemia;Kainic Acid Receptors;Location;Long-Term Potentiation;Medial;Memory;memory encoding;Mental Depression;Mind;Minority;model organism;Molecular;Moods;mossy fiber;Mothers;mu opioid receptors;Mus;N-Methyl-D-Aspartate Receptors;National Institute of Neurological Disorders and Stroke;Nature;neocortical;nerve supply;neural circuit;neuronal cell body;Neurons;Neurosurgeon;neurosurgery;nonhuman primate;offspring;Operative Surgical Procedures;opioid use;optogenetics;Output;Pain;Physiological;Physiology;Play;Population;Positioning Attribute;postsynaptic;presynaptic;Primates;Property;Provider;Proxy;Pyramidal Cells;Receptor Activation;receptor expression;receptor sensitivity;Regulation;Reporting;Research;Research Personnel;Resected;Rodent;Role;Schizophrenia;Shapes;Shunt Device;Site;Stroke;Structure;Synapses;Synaptic plasticity;Synaptic Transmission;Tissues;transcriptomics;Transgenic Animals;transmission process;United States National Institutes of Health;Universities;Viral;virtual;Work

PROJECT_TITLE: Cellular And Synaptic Physiology Of Hippocampal Interneurons


ORG_CITY: MILPITAS

ORG_NAME: GATE SCIENTIFIC, INC.

ORG_STATE: CA

PI_NAMEs: SCABOO, KRIS  (contact)

PROJECT_TERMS: Acute;Antibody Response;antiretroviral therapy;Binding;Biological Assay;Chronic;Contracts;cost;design;Development;diagnostic assay;Goals;HIV;HIV Infections;HIV-1;Home;Human;Human immunodeficiency virus test;Individual;Infection;Interruption;Laboratories;Location;Monitor;Nucleic Acid Amplification Tests;Persons;point of care;pre-exposure prophylaxis;programs;Rapid diagnostics;Risk;RNA-Directed DNA Polymerase;Sampling;self testing;Testing;Viral;viral detection;Viral Load result;Whole Blood

PROJECT_TITLE: Development of a Disposal Point-of-Care HIV Nucleic Acid Test


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: LUNA LABS USA, LLC

ORG_STATE: VA

PI_NAMEs: SENPAN, ANGANA  (contact)

PROJECT_TERMS: Acute;Antibody Response;antiretroviral therapy;Binding;Biological Assay;Chronic;Contracts;cost;design;Detection;diagnostic assay;Goals;HIV;HIV Infections;HIV-1;Home;Human immunodeficiency virus test;Individual;Infection;Interruption;isothermal amplification;Laboratories;Location;Microfluidics;Monitor;Nucleic Acid Amplification Tests;Persons;pre-exposure prophylaxis;programs;Rapid diagnostics;Risk;Sampling;self testing;Technology;Testing;Viral;viral detection;Viral Load result;Visual

PROJECT_TITLE: AmpFLI: Rapid Nucleic Acid Test for HIV-1


ORG_CITY: ELLICOTT CITY

ORG_NAME: VITRUVIAN BIO, LLC

PROJECT_TERMS: Acute;Antibody Response;antiretroviral therapy;Binding;Biological Assay;Biological Markers;Chronic;Contracts;cost;design;detection assay;diagnostic assay;Enterobacteria phage MS2;Goals;HIV;HIV Infections;HIV-1;Home;Human immunodeficiency virus test;Individual;Infection;Interruption;Laboratories;Location;Microfluidics;Monitor;monitoring device;Nucleic Acids;Persons;pre-exposure prophylaxis;programs;Rapid diagnostics;Risk;RNA;RNA Phages;Sampling;self testing;Testing;Viral;viral detection;Viral Load result

PROJECT_TITLE: An Electrochemical Self-Monitoring Device for Rapid Nucleic Acid Based Testing of HIV-1


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: RANCHO DOMINGUEZ

ORG_NAME: MOLECULAR EXPRESS, INC.

PI_NAMEs: HO, SAMON  (contact)

PROJECT_TERMS: Address;Adjuvant;Animals;Antibodies;Antibody Response;Antigens;Attention;Contracts;design;Development;Engineering;env Gene Products;Epitopes;Formulation;Goals;HIV;HIV vaccine;Immune response;immunogenic;improved;Lipids;Modality;nanoparticle;neutralizing antibody;next generation;novel;particle;Polymers;Vaccine Research

PROJECT_TITLE: Design and Engineering of VesiVax HIV Immunogen Formulations


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: AMES

ORG_NAME: NEOVAXSYN, INC.

ORG_STATE: IA

PI_NAMEs: RAYCHAUDHURI, SANTANU  (contact)

PROJECT_TERMS: Address;Adjuvant;Animals;Antibodies;Antibody Response;Antigens;Attention;Contracts;design;Development;env Gene Products;Formulation;Goals;HIV;HIV vaccine;HIV-1;Immune response;improved;Lipids;Modality;nanoGold;nanoparticle;nanovaccine;neutralizing antibody;next generation;particle;Peptides;Polymers;vaccine delivery;Vaccine Research

PROJECT_TITLE: Nanovaccine for Eliciting bnAbs Against HIV-1


ORG_CITY: BROOMFIELD

ORG_NAME: DARWIN BIOSCIENCES, INC.

ORG_STATE: CO

PI_NAMEs: MEYERSON, NICHOLAS RYAN (contact)

PROJECT_TERMS: Acute;Antibody Response;antiretroviral therapy;Binding;Biological Assay;Chronic;Contracts;cost;design;Detection;diagnostic assay;Early identification;Goals;HIV;HIV Infections;HIV-1;Home;Human immunodeficiency virus test;Individual;Infection;Interruption;Laboratories;Location;Molecular;Monitor;Nucleic Acid Amplification Tests;Persons;pre-exposure prophylaxis;programs;Rapid diagnostics;Risk;Sampling;Self Administration;self testing;Sensitivity and Specificity;Testing;Viral;viral detection;Viral Load result

PROJECT_TITLE: The HIV-Stick Assay: A Rapid, Molecular Detection Approach for Self-Monitoring HIV-1 Rebound Infection


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Agreement;Basic Science;cGMP production;Clinical;Clinical Research;clinical research site;cohort;Cohort Studies;Critical Pathways;Cyclic GMP;Data;design and construction;Developing Countries;Development;efficacy testing;Epidemic;epidemiology study;Evaluation;HIV;HIV vaccine;HIV/AIDS;Human;Immunization;immunogenicity;Incidence;International;manufacture;Medical Research;Military Personnel;National Institute of Allergy and Infectious Disease;operation;Phase;pilot lot production;pre-clinical research;preclinical development;programs;quality assurance;Regimen;repository;Research;research and development;Research Institute;research study;Safety;Sampling;Site;Specimen Handling;Thailand;vaccine candidate;vaccine development;Vaccine Research;Vaccines;Work

PROJECT_TITLE: HIV Vaccine Research and Development - NIAID DAIDS Vaccine Research Program


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;HIV/AIDS;Immunization;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Prevention;Vaccine Related

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Africa;Area;Basic Science;Central Nervous System;Clinical Research;cohort;Collaborations;Developing Countries;Epidemic;high risk;HIV;HIV Infections;HIV vaccine;HIV/AIDS;International;Medical Research;Military Personnel;National Institute of Allergy and Infectious Disease;National Institute of Mental Health;Nervous System;neuroAIDS;Neurologic;Oral;Outcome;Participant;Population;preclinical development;programs;Research;research and development;Research Institute;response;Safety;Thailand;vaccine development;Vaccine Research;Vaccines;Work;working group

PROJECT_TITLE: HIV Vaccine Research and Development – NIMH Division of AIDS Research


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Comparative Effectiveness Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Orphan Drug;Ovarian Cancer;Patient Safety;Precision Medicine;Racial and Ethnic Minority Health Research;Rare Diseases;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE Ovarian cancer is the deadliest gynecologic malignancy in the U.S. and innovative approaches for achieving optimal outcomes are desperately needed. We propose to establish a multi-institutional cohort of racially and ethnically diverse women with the most common and one of the deadliest histotypes of ovarian cancer, high- grade serous ovarian cancer (HGSOC), with standard of care (SOC) computed tomography (CT) images prior to treatment and well-annotated clinical and outcomes data to identify and validate image-based features predictive of survival. This work will provide readily calculable, non-invasive biomarkers from SOC CT images for clinically translational information to aid in patient stratification efforts that will ultimately improve outcomes among women with HGSOC.

PI_NAMEs: CANNIOTO, RIKKI ;PERES, LAUREN COLE (contact);SCHABATH, MATTHEW B.

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Adipose tissue;Adjuvant Chemotherapy;adverse outcome;Biological;Biological Markers;Biometry;Body Composition;Body measure procedure;cancer care;Cancer Center;Cancer Patient;cancer survival;chemotherapy;Clinical;clinical care;Clinical Data;clinical decision support;clinical translation;clinically relevant;cohort;Continuity of Patient Care;Data;Diagnosis;digital;Disease;Epithelial ovarian cancer;ethnic diversity;ethnic minority;Ethnic Population;experience;Explosion;Future;Genomics;Goals;Healthcare;Hematology;Image;imaging biomarker;imaging software;improved;improved outcome;innovation;Institution;interest;Machine Learning;machine learning method;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Measures;Medical Imaging;minority patient;Modeling;Monitor;Muscle;muscle form;Neoadjuvant Therapy;Oncology;Operative Surgical Procedures;Outcome;ovarian neoplasm;Ovarian Serous Adenocarcinoma;Pathology;Patient imaging;patient stratification;patient subsets;Patient-Focused Outcomes;Patients;Performance;personalized medicine;predictive modeling;Progression-Free Survivals;Proteomics;quantitative imaging;racial diversity;racial minority;racial population;radiomics;Recurrence;Reproducibility;Research;Resources;Risk;Scanning;Serous;Skeletal Muscle;Source;Stage at Diagnosis;standard care;standard of care;Standardization;Stratification;subcutaneous;Subgroup;survival prediction;Testing;Therapeutic;Third lumbar vertebra;Time;time use;Training;treatment response;Tumor Debulking;Validation;Visceral;Woman;women's diagnosis;women's outcomes;women's treatment;Work;X-Ray Computed Tomography

PROJECT_TITLE: Radiomic biomarkers for clinical decision support that predict patient outcomes in serous ovarian carcinoma

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Cancer;Liver Disease;Microbiome;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: DAVIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE There are increasing incidence and mortality rates for hepatocellular carcinoma (HCC) in the United States that are disproportionately impacting the Latinx population for poorly understood reasons. This study will recruit individuals with liver cirrhosis, precursor for liver cancer, to explore mechanisms of the gut-liver axis that contribute to HCC risk and will provide critical information for future HCC mitigation and prevention strategies.

PI_NAMEs: HUSSAIN, SHEHNAZ KHURSHEED (contact)

PROGRAM_OFFICER_NAME: SIMONDS, NAOKO ISHIBE

PROJECT_TERMS: Adult;Affect;Anatomy;Automobile Driving;Bacteria;Behavioral;Bile Acids;Biogenic Amines;Biological;Biological Factors;Biological Markers;biomarker discovery;Biopsy;Biopsy Specimen;Blood;Blood specimen;California;carcinogenicity;Circulation;Cirrhosis;Clinical;Clinical Data;Coffee;cohort;curative treatments;Data;data integration;Death Rate;Development;Diagnosis;Diet;Dietary Factors;Dinoprostone;Disparity;disparity reduction;Duodenum;Economics;Enrollment;Ensure;Environmental Risk Factor;epidemiologic data;Epidemiology;Ethnic Origin;Ethnic Population;Etiology;Experimental Designs;experimental study;Fiber;first-in-human;follow-up;Future;genotoxicity;Glycopeptides;Glycoproteins;glycosylation;Goals;gut microbiota;gut-liver axis;healing;health equity;Healthy Eating;Hepatocarcinogenesis;high risk;Human;immune activation;Immune Sera;Immunoglobulin A;Immunoglobulins;Immunologic Markers;immunoregulation;Incidence;indexing;Individual;Intervention;Knowledge;Latinx;Latinx population;Life Style;liquid chromatography mass spectrometry;Liver;Liver Cirrhosis;Liver diseases;Malignant neoplasm of liver;Mannose;Mass Spectrum Analysis;Medical Records;men;Metabolic dysfunction;metagenomic sequencing;Methionine;methionine sulfoxide;Mexican;Mexico;Microbe;microbial;microbiome;microbiome composition;microbiota;mortality;Mucins;mucosal microbiota;Mucous Membrane;multi-ethnic;Multiomic Data;multiple reaction monitoring;novel;novel marker;Organ;Participant;Pathway interactions;Patients;personalized strategies;Persons;Physiological;Polysaccharides;Population;predictive marker;Predisposition;Prevention;Prevention strategy;Primary carcinoma of the liver cells;prophylactic;prospective;Prospective cohort;Prospective Studies;Proteins;Publishing;racial population;Recording of previous events;recruit;Reporting;Research;Risk;Risk Assessment;Rodent;Role;Secondary to;Serum;sialylation;Site;social;social factors;social health determinants;Specimen;surveillance imaging;surveillance strategy;Taurocholic Acid;Translations;Triage;United States;Validation;Visit;Woman

PROJECT_TITLE: Epidemiology of the gut-liver axis and hepatocellular carcinoma risk in a multiethnic liver cirrhosis cohort: defining the role of bacteria, metabolites, and glycoproteins


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PI_NAMEs: BYNUM, JULIE PW (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;analytical tool;Area;Collaborations;Communication;Communities;Complex;Consult;cost;Data;design;Development;Discipline;Discipline of Nursing;dissemination strategy;Economics;Ensure;federal policy;Foundations;Funding;Goals;Government;Grant;Health;Health Care Research;Healthcare;Healthcare Systems;Infrastructure;Institution;International;Knowledge;Leadership;Measures;Medicine;Methods;Michigan;Monitor;novel;Observational Study;Persons;Pilot Projects;Policy Maker;Policy Making;Population;Population Research;Population Sciences;Process;Public Health Schools;Research;Research Design;Research Personnel;Research Support;Resources;Secondary to;social;Strategic vision;Structure;success;Technology;Time;tool;Training;Training Support;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: No Text

PI_NAMEs: SIEGE, BRUCE  (contact);THESSEN, ANNE E

PROGRAM_OFFICER_NAME: MILLER, CHRISTOPHER MANDEL

PROJECT_TERMS: catalyst;data management;programs;Text

PROJECT_TITLE: BioData Catalyst Data Management Core Program


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PI_NAMEs: SHAH, MAUNANK  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Accountability;Address;Adherence;AIDS clinical trial group;Award;Baltimore;Belief;Bioethics;Biological Specimen Banks;Brazil;career;Caring;case finding;Categories;Cities;Clinic;Clinical;clinical care;clinical implementation;Clinical Investigator;Clinical Research;clinical research site;Clinical Sciences;Clinical Services;Clinical Trials;co-infection;cohort;Collaborations;Communication;Communities;comorbidity;cost;Country;Coupled;data resource;Databases;Detection;Development;Diagnostic;Disease;Ensure;Environment;epidemiology study;Ethics;Faculty;FAIR principles;Feedback;Fostering;Foundations;Funding;Generations;global health;Goals;Grant;Health;HIV;Human Resources;Human Subject Research;implementation intervention;improved;Incidence;Incubated;India;Infection;Infrastructure;innovation;Institution;Institutional Review Boards;interdisciplinary collaboration;Interdisciplinary Study;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Investigation;K-Series Research Career Programs;Knowledge;Link;material transfer agreement;Measures;meetings;Mentors;Mentorship;Methodology;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Natural History;Newsletter;next generation;novel;Pathogenesis;patient population;Patients;Persons;Policies;Population;pregnant;Prevention;Preventive therapy;Process;Public Health;public health research;Recovery;Reporting;Research;Research Activity;Research Infrastructure;Research Methodology;Research Personnel;Research Priority;Research Support;Resources;searchable database;Series;skills;South Africa;Specimen;Stream;Structure;Sum;supportive environment;symposium;synergism;Talents;Therapeutic;Translating;Translational Research;transmission process;Tuberculosis;Uganda;United States National Institutes of Health;Universities;Update;web site;Work;Writing

PROJECT_TITLE: Clinical Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Recognizing that chronic diseases, including Alzheimer’s Disease (AD) and Related Dementia (AD/ADRD), do not exist solely as isolated entities, the use of large longitudinal datasets such as electronic health records (EHRs) becomes a key novel asset with potential to advance understanding and management of dynamic personalized risk in the layered complexity involving variations through risk factors, and concomitant diseases. Thus, we propose to federate a unique multiethnic 3-city EHR consortium in NY, Miami and Chicago, encompassing 9 million patients records (59,000 of them with AD/ADRD) embedded in census-track level social determinants of health, and to use machine learning and novel dynamic predictive and causal inference methods to identify accelerators or decelerators of AD/ADRD. This work will inform strategies to tailor risk prediction, inform complex clinical management and build a multiethnic harmonized dynamic platform ready for real-world evaluation of future treatments of AD/ADRD.

PI_NAMEs: DESVARIEUX, MOISE  (contact);HRIPCSAK, GEORGE M;MAYEUX, RICHARD P

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;apolipoprotein E-4;Big Data;Biological Markers;Birth Place;Black race;blood pressure control;Body System;cardiometabolism;Caring;Censuses;Chicago;Chronic;Chronic Disease;Cities;Clinical;clinical data warehouse;Clinical Management;Clinical Research;cohort;Complex;Data;Data Linkages;data warehouse;dementia risk;Diabetes Mellitus;Diagnosis;Disease;Disease Clusterings;Education;Electronic Health Record;Enrollment;Epidemiology;Ethnic Origin;Evaluation;Evolution;experience;Future;Gender;Genetic;genome wide association study;glycemic control;Goals;Health;health data;Health Personnel;Heterogeneity;Hispanic;Hospitals;Hypertension;Image;improved;Incidence;Income;Individual;individualized prevention;innovation;Insurance Coverage;Life;longitudinal dataset;Machine Learning;Magnetic Resonance Imaging;Managed Care;Medical Informatics;Medicine;Mental Health;Methods;mindfulness;Minority Groups;minority health;Modeling;Morbidity - disease rate;multi-ethnic;multiple chronic conditions;Natural History;Natural Language Processing;Neighborhoods;New York;novel;Outcome;Participant;Pathology;Patients;Pattern;Persons;Pharmaceutical Preparations;Polypharmacy;Presbyterian Church;Prevention;Preventive measure;Procedures;protective factors;Provider;Public Health;Qualifying;Race;Records;Research;Research Personnel;Resources;Risk;Risk Factors;risk prediction;Security;sex;Smoking;social;social determinants;social health determinants;Socioeconomic Factors;socioeconomics;Statistical Methods;System;Time;Universities;Variant;Vascular Diseases;Weight;Work

PROJECT_TITLE: Multi-morbidity 3-City Alzheimer's Disease EHR Study (M3AD Study)

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE β-cells adapt their insulin secretory response to compensate for increased insulin demand in obesity; however long-term overnutrition can also become maladaptive and lead to β-cell failure and diabetes. How β-cells read nutrient signals and translate these signals into adaptive and maladaptive responses is poorly understood. Here, we will determine how regulation of the β-cell epigenome by the nutrient-sensitive histone demethylase LSD1 mediates adaptive and maladaptive processes in β-cells.

PI_NAMEs: WORTHAM, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Acceleration;Acute;Affect;Beta Cell;Caloric Restriction;Cell Line;Cell Physiology;Cells;Chromatin;Chronic;cofactor;Collection;Compensation;Computer Analysis;Cues;detection of nutrient;Diabetes Mellitus;endocrine pancreas development;Environment;Epigenetic Process;epigenome;epigenomics;Exhibits;experimental study;Failure;feeding;functional adaptation;Functional disorder;Funding;Gene Expression;Genes;Genetic;Genetic Transcription;Glucose;glucose metabolism;Goals;Grant;Histone Acetylation;Histone Deacetylase;histone demethylase;histone methylation;Hormones;Human;improved;In Vitro;in vivo;insight;Insulin;insulin regulation;insulin secretion;islet;KDM1A gene;Link;Lipids;Maps;Measures;Mediating;Metabolic;Metabolic stress;Modeling;Modification;Molecular;mouse model;Mus;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Obesity;Output;Overnutrition;Pathway interactions;Phenotype;Physiological;Plasma;Prediabetes syndrome;prevent;Process;programs;Proliferating;recruit;Regulation;Regulatory Element;Resolution;response;Role;scaffold;Signal Transduction;Stimulus;Structure of beta Cell of islet;Testing;Therapeutic;Thinness;transcriptomics;Translating;Transplantation

PROJECT_TITLE: Epigenetic determinants of beta cell development and function


NIH_SPENDING_CATS: Data Science;Genetics;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The goal of this MIRA project is to develop data-driven and AI empowered systems biology approaches to accurate assess biological processes by using omics data, including a natural language processing-based model construction, a new AI framework to approximate systems biology models, and related computational principles. The proposed framework will systematically characterize the biological processes, such as metabolic and signaling pathways, as well as their heterogeneities and crosstalk in disease tissue microenvironment, and identify key influencing factors in complex disease by analyzing omics data. Given the pervasive role of metabolism and signaling pathways in essentially every aspect of the disease pathology, the proposed infrastructure with accurate characterization of functional variations could have far-reaching impact in our knowledge on the basis of disease biology, clinical early diagnosis and prevention, and disease management.

PI_NAMEs: ZHANG, CHI  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;advanced system;Biochemical;Biological;Biological Markers;Biological Process;Biology;Biomedical Research;Cell Physiology;Cells;Clinical;Communities;Complex;computational suite;computer framework;computerized tools;Computing Methodologies;Data;Data Analyses;Dependence;Development;Differential Equation;Disease;Disease Management;Disease Progression;drug repurposing;dynamic system;Early Diagnosis;empowerment;Endowment;epigenetic regulation;Foundations;Genetic Annotation;Genetic Variation;Goals;Heterogeneity;human disease;information organization;Infrastructure;Knowledge;Literature;Mathematics;Metabolic;Metabolic Pathway;Metabolism;Methodology;Methods;Modeling;Molecular;Multiomic Data;Natural Language Processing;new therapeutic target;novel;nutrition;Pathology;Phenotype;precision medicine;Prevention;Recommendation;Research;Role;Sampling;Signal Pathway;Structure;System;Systems Biology;theories;Tissues;Transcriptional Regulation;transcriptomics;Validation;Variant

PROJECT_TITLE: Development of data driven and AI empowered systems biology to study human diseases


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE This two-phase “health equity acceleration” U01 application is submitted to participate in the FDA OMHHE Health Equity Innovation Award for “Racial & Ethnic Minority Acceleration Consortium for Health Equity (REACH) (U01)” focused on advancing “minority health and health equity focused research, outreach, and communications as well as support training and mentoring of diverse HBCU advanced students, fellows, and researchers.” Two pilot projects/programs submitted in this application will be developed under Phase 1, and subsequently implemented under Phase 2: a) A Pilot curriculum on “Regulatory Issues and Health Equity” and potential FDA OMHHE rotations for advanced students and faculty in HBCUs in Pharmacy (XULA College of Pharmacy) and Nursing (Helene Fuld School of Nursing CSU); and b) A Pilot research project which will move the discussion beyond barrier identification to develop strategies to address barriers to clinical trial diversity, in order to increase trustworthiness, enhance transparency in sponsors and researchers, and bolster willingness to participate for African Americans, thereby strengthening equity in participation of underrepresented minority racial and ethnic groups in clinical trials.

PI_NAMEs: BAQUET, CLAUDIA R0SE (contact)

PROGRAM_OFFICER_NAME: LEE, CHRISTINE

PROJECT_TITLE: Racial and Ethnic Minority Acceleration for Health Equity Consortium U01


ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: PROJECT NARRATIVE This proposal seeks the establishment of the Puerto Rico Racial & Ethnic Minority Acceleration Consortium for Health Equity (PR-REACH) to support the advancement of Hispanic Puerto Ricans health equity, this is a first step in a research agenda to collaborate with the Food and Drug Administration (FDA) Office of Minority Health and Health Equity (OMHHE) across REACH research projects and activities by first building an administrative research and communication infrastructure; leadership team, three EQUITY research cores (Clinical Trials, Voices and Data), a training and mentoring core, and an advisory team. A pilot study under this consortium will be conducted to advance the understanding of substance use disorder patients’ journey as perspectives, preferences and unmet needs regarding substance use disorder (SUD) treatment with FDA approved medications in PR to be able to improve its outcomes and launch PR-REACH in PR. The PR-REACH will initiate with Hispanics living in Puerto Rico as a model than can inform and guide subsequent extrapolation to Hispanics in the US in collaboration with the FDA.

PI_NAMEs: MARTINEZ GONZALEZ, KAREN G.;SANTIAGO, DARLENE I (contact)


ORG_CITY: HONOLULU

ORG_NAME: QUEEN'S MEDICAL CENTER

ORG_STATE: HI

PHR: Project Narrative Our project will create a “Hawai‘i Health Equity Research and Outreach Network (HAWAI‘I HERON)” that will provide resources to support efforts to improve health equity for Asian American, Native Hawaiian and other Pacific Islander (AA-NHPI) populations. This work will be in collaboration with the Food and Drug Administration and other minority-serving institutions and will include a pilot study examining AA-NHPI patient preferences for diabetes medications. HAWAI‘I HERON has the potential to strengthen health equity focused research, outreach and communications, and training and mentoring of diverse students and junior researchers.

PI_NAMEs: SETO, TODD B (contact);TAIRA, DEBORAH ANN


ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA COMMUNITY HEALTH CTR/ASSN

PHR: NARRATIVE: Increasing the diversity of clinical trial participants is key to advancing health equity. This project aims to increase the recruitment of diverse participants in research through established provider and community health worker relationships in minority communities using new, interactive community driven curricula.

PI_NAMEs: HAYES, REBECCA  (contact)

PROJECT_TITLE: Improving Multicultural Engagement in Clinical Research through Partnership with Federally Qualified Health Centers and Community Health Worker Programs


ED_INST_TYPE: SCHOOLS OF NURSING

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: PROJECT NARRATIVE  The advent of remote technologies such as video conferencing and secure web-portals have revolutionized approaches to health data collection and access to healthcare, where these technologies can be deployed in fully remote and hybrid approaches for clinical trials which could help promoting more participation among under-represented groups as well as by bridging geographic distance and reducing participant burden (e.g., less travel time, more flexibility and confidentiality). However, these approaches have yet to be optimized for all possible beneficiaries of technological advances in clinical trials and healthcare, especially targeting under- represented populations that are disproportionately experiencing social and geographic isolation. To address these concerns, the current proposal seeks to leverage the team’s existing community connections in states across 4 different regions of the U.S. among the Asian American and Pacific Islander (including Native Hawaiian), American Indian, Hispanic/Latino, and sexual and gender minority populations to: (1) (a) co-create and maintain 4 virtual and hybrid advisory groups to address health issues and (b) develop materials for the conduct of remote advisory groups; (2) co-develop and administer a national needs assessment survey for the referenced 4 groups (N = 800) addressing the use of home self-testing technology (up to 3 types) and remote data collection for healthcare research and healthcare provision; and (3) pilot community driven approaches to introducing home self-testing technology and remote data collection to potential participants from these groups to assess feasibility and acceptability.

PI_NAMEs: FLORES MILLENDER, EUGENIA  (contact);WONG, FRANK Y.;XAVIER HALL, CASEY DANIEL

PROJECT_TITLE: Elevating Community Voices by Developing a User-centered Approach to Enable Self-testing and Remote Data Collection among Under-represented Populations (Project Elevate)


ORG_CITY: ALBUQUERQUE

ORG_NAME: AMERICANS FOR INDIAN OPPORTUNITY

ORG_STATE: NM

PHR: Project Narrative Three sentences   With a collaborative approach grounded in Indigenous core cultural values, the Indigenous Innovators Collaborative (IIC) team will engage in community-based participatory research study to address the FDA priorities as outlined in FDA OMHHE Health Equity Innovation Award: Racial and Ethnic Minority Acceleration Consortium for Health Equity (REACH) funding opportunity. The IIC seeks to engage American Indian and Alaska Native (AIAN) communities, stakeholders, researchers in an exploration of clinical trials and promote cultural knowledge in understanding clinical trials in Indian Country. One of the fundamental goals of this study is to aid in identifying perceptions of clinical trials and gene therapy within the Native American population.

PI_NAMEs: KIPP, BILLIE ;PARKER, MYRA ELIZABETH;POSTON, STEPHINE  (contact)

PROJECT_TITLE: Racial & Ethnic minority Acceleration Consortium for Health Equity (REACH) Response from Indigenous Innovators Collaborative


ORG_CITY: LOMA LINDA

ORG_NAME: VA LOMA LINDA HEALTHCARE SYSTEM

PHR: PROJECT NARRATIVE: Improving Restoration of Middle-Ear Function Following Blast-Related Injuries Because of the environments in which military personnel operate, they are significantly more likely to suffer service-related hearing losses. Restoration of hearing following conductive hearing loss due to excessive blast- related noises has had limited success, because the hearing field currently has only a rudimentary understanding of how the structures of the middle ear transmit sound under pathological conditions. The studies in the current proposal will significantly advance our knowledge of how middle-ear structures work to accurately transmit sound. By measuring sound-pressure levels and movements of middle-ear structures in normal and damaged ears, we can more precisely diagnose the specific causes of a blast-induced hearing loss, and design and implement more effective surgical methods and replacement prosthetics to optimally restore hearing. The knowledge gained from the proposed research will be of value not only in habilitating military personnel and Veterans, but also for other patients suffering from conductive hearing losses.

PI_NAMEs: DONG, WEI  (contact)

PROJECT_TERMS: 3-Dimensional;Acoustics;active duty;Anatomic Models;Animal Model;Auricular prosthesis;bone;Cadaver;Characteristics;Clinical;clinical diagnosis;Clinical Treatment;Cochlea;Complex;Conductive hearing loss;Congenital Abnormality;Data;design;Development;Devices;Diagnosis;Dislocations;Ear;Ear Injury;Ear ossicles;Environment;Evaluation;Excision;Exhibits;experience;Experimental Models;Failure;flexibility;Frequencies;Gerbils;Glues;Goals;healing;Hearing;hearing impairment;hearing restoration;Human;improved;Incus;Individual;Injury;Intraoperative Monitoring;Investigation;Knowledge;Labyrinth;Lasers;manubrium;Measurement;Measures;Methods;middle ear;Military Personnel;military veteran;Modeling;Monitor;Morphology;Motion;Movement;Noise;normal hearing;operation;Operative Surgical Procedures;otoacoustic emission;Outcome;Pathologic;Pathology;Patients;Pattern;Perforation;physical property;Preparation;pressure;pressure sensor;Procedures;Process;Production;Prosthesis;rational design;reconstruction;Reconstructive Surgical Procedures;repaired;Research;Residual state;restoration;Role;Rupture;sample fixation;Services;Soldier;sound;Stapes;Structure;success;Surgical Disarticulation;System;Temporal bone structure;Testing;Time;tool;transmission process;tumor;Tympanic membrane;Tympanic Membrane Perforation;Veterans;Work

PROJECT_TITLE: Improving Restoration of Middle-Ear Function Following Blast Related Injuries

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]