NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

PHR: We propose to develop, evaluate and disseminate a health information technology (IT)-enabled, multilevel, stepped care intervention grounded in primary care, PREDICT (Personalized Risk-based Follow-up of Cervical Cancer Screening in Practice), to improve timely and appropriate care for cervical cancer screening and management (CCSM). PREDICT components include: 1) system redesign to deliver CCSM recommendations at a population level, 2) support for individual patient and clinician engagement, and 3) enhanced team coordination through an efficient “stepped care” approach. The effectiveness and implementation of PREDICT will be evaluated (vs. standard care) by conducting a 3-arm cluster randomized controlled trial (RCT) of individuals in 4 primary care networks, coupled with a rigorous implementation evaluation, to achieve the sustainability and dissemination of this intervention.

PI_NAMEs: ATLAS, STEVEN J;HAAS, JENNIFER S (contact)

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: Address;Adoption;Age;Algorithms;American;arm;Biopsy;cancer prevention;cancer risk;care coordination;Caring;Cervical;Cervical Cancer Screening;Clinical;clinical decision support;clinical practice;Colposcopy;comorbidity;Complex;Coupled;Cytology;Data;data standards;design;Diagnosis;Diagnostic;Diagnostic Procedure;Early Diagnosis;effective therapy;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;Electronic Health Record;Eligibility Determination;Evaluation;evidence base;Excision;experience;Failure;follow-up;Future;Guidelines;Gynecology;Harm Reduction;health information technology;Health system;Healthcare Systems;high risk population;Histopathology;Human Papillomavirus;implementation evaluation;improved;Individual;individual patient;informatics infrastructure;Infrastructure;Intervention;Interview;Intraepithelial Neoplasia;Lesion;Maintenance;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Modality;Modeling;mortality;Natural Language Processing;Notification;open source;Outcome;outreach;overtreatment;Pap smear;participant enrollment;Pathology;Patient Care;Patients;personalized management;Population;population based;pragmatic trial;premalignant;Prevention;Preventive care;Primary Care;primary outcome;Process;Provider;Quality of Care;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reflex action;Research Design;response;Risk;Risk Estimate;screening;Screening for cancer;screening guidelines;Screening Result;Societies;Spanish/English;Specialist;standard care;Surveys;System;Test Result;Testing;tool;United States;United States Preventative Services Task Force;Visit;Work

PROJECT_TITLE: Personalized Risk-based Follow-up of Cervical Cancer Screening in Practice (PREDICT)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The mTOR pathway is a master regulator of nutrient metabolism and cell proliferation in response to environmental cues. Elucidating the mechanistic role of mTOR in regulating tumor cell dormancy and persistence is critical for clinical treatment of many human cancers.

PI_NAMEs: LI, YULIN  (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: Ablation;antiporter;Biogenesis;Breast Cancer Patient;cancer therapy;Cell Proliferation;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Chromosome Mapping;Clinical;Clinical Treatment;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;confocal imaging;CRISPR library;Cues;Development;Diapause;drug sensitivity;Drug Tolerance;Embryo;Embryonic Induction;Environment;environmental change;extracellular;FRAP1 gene;Future;Genetic;genome-wide;Goals;Human;Hypersensitivity;Iron;Lead;Lysosomes;Malignant Neoplasms;Mediating;microscopic imaging;mTOR inhibition;mTOR Inhibitor;MYC Family Protein;neoplastic cell;non-genetic;novel;novel strategies;novel therapeutic intervention;Nuclear;nutrient metabolism;Outcome;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Pilot Projects;Pre-Clinical Model;prevent;Primary Neoplasm;protein expression;Recurrent tumor;Regulation;Reporting;Residual Neoplasm;response;Role;screening;Signal Transduction;Small Molecule Chemical Library;Specimen;System;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Tissues;transcriptomics;Transmission Electron Microscopy;triple-negative invasive breast carcinoma;tumor;tumorigenesis

PROJECT_TITLE: Functional roles of mTOR in tumor persistence

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: AUGUSTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: This project will test the hypothesis that interorgan communication between the adrenal glands and skeleton via endogenous glucocorticoids is a key component of aging-related musculoskeletal dysfunction, and will test whether signaling downstream of endogenous glucocorticoids is mediated by the mineralocorticoid receptor or glucocorticoid receptor in aging bone.

PI_NAMEs: MCGEE-LAWRENCE, MEGHAN E. (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acceleration;Address;Adipose tissue;Adrenal Glands;Adult;Adverse effects;Affinity;Age;age related;Age related pathologies;aged;Aging;aging related;Animal Model;Binding;Biochemistry;Biology;blood pressure regulation;bone;bone aging;bone loss;Bone Marrow;bone mass;Bone Tissue;bone turnover;Cell Proliferation;Cells;ChIP-seq;circadian;Clinical;Communication;conditional knockout;Data;Development;Dose;drug repurposing;Endocrine;Enzymes;eplerenone;Equilibrium;Failure;Fatty acid glycerol esters;frailty;Functional disorder;Glucocorticoid Receptor;Glucocorticoids;Goals;Hormonal;Hormones;Human;improved;In Vitro;in vivo;inhibitor;Knockout Mice;Knowledge;Mediating;Mediator;Mesenchymal Stem Cells;Mineralocorticoid Receptor;Modeling;Molecular;mouse model;Mus;Muscle;Musculoskeletal;Musculoskeletal System;new therapeutic target;novel;old mice;Organ;Osteoblasts;overexpression;paracrine;Pathology;Pathway interactions;Peripheral;pharmacologic;Phenotype;Physical activity;Physiological;prevent;Production;Publications;Publishing;Receptor Activation;receptor expression;Receptor Inhibition;reduced muscle mass;Research;Role;Serum;Signal Transduction;skeletal;Skeletal Muscle;Skeleton;steroid hormone;System;Testing;Tissues;TNFSF11 gene;young adult

PROJECT_TITLE: Endogenous steroid hormones as mediators of interorgan communication with the musculoskeletal system

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-P (J2)]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

PHR: Narrative High resolution in vivo micro-computed tomography (microCT) has become a “gold standard” for imaging and analysis of bone and other tissues (fat, muscle, contrast-enhanced vasculature) in longitudinal studies, but our institution currently lacks such an instrument. Augusta University has many NIH-supported projects that would benefit from this high resolution tool, which would enhance the precision, rigor, and reproducibility of our investigators’ funded and preliminary studies. The Functional Outcomes Core at AU has extensive scientific, technical, and administrative experience with in vivo and ex vivo imaging technology, including microCT, and the institution is in full support of this application.

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: 3-Dimensional;Agreement;Award;Body Composition;bone;Bone Density;Collaborations;Computed Tomography Scanners;Contract Services;contrast enhanced;Dual-Energy X-Ray Absorptiometry;Ensure;ex vivo imaging;experience;experimental study;Faculty;Fatty acid glycerol esters;functional outcomes;Funding;Funding Mechanisms;Grant;Image;Imaging technology;in vivo;Institution;instrument;instrumentation;International;Investments;Journals;Longitudinal Studies;Manuscripts;microCT;mineralization;Mission;Muscle;novel;Program Research Project Grants;programs;Publishing;recruit;Reproducibility;Research;Research Personnel;Resolution;Resources;Running;Site;soft tissue;Structure;System;Techniques;Technology;Time;Tissue Sample;Tissues;tool;Tooth structure;United States National Institutes of Health;Universities;Vertebrates

PROJECT_TITLE: SKYSCAN 1276

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-M (30)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: HERSHEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Narrative Statement The vagus nerve, the main interoceptive connection between the brain and body, represents a novel target for treatment of alcohol use disorders (AUD), the third leading cause of preventable death in the U.S. This preclinical translational study will be the first of its kind to use a combination of behavioral, electrophysiological, molecular, histological and viral transgenic techniques to investigate the mechanisms by which vagus nerve disruptions, particularly loss of gastric vagal control over central hypothalamic signaling, promotes increased alcohol preference in rodent models. Findings from these studies will fill critical gaps in our current knowledge of vagally mediated alterations in alcohol-related behaviors that could be used to develop novel strategies for AUD treatments.

PI_NAMEs: HAJNAL, ANDRAS ;SILBERMAN, YUVAL  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Address;Adult;Affect;alcohol abuse therapy;alcohol behavior;Alcohol consumption;alcohol craving;alcohol exposure;alcohol relapse;alcohol reward;alcohol seeking behavior;alcohol use disorder;Alcohols;antagonist;Behavioral;Biological Markers;Brain;Brain Diseases;Central Nervous System;Chronic;chronic alcohol ingestion;Clinical;Clinical Data;conditioned place preference;Corticotropin-Releasing Hormone;craving;Data;Dependence;designer receptors exclusively activated by designer drugs;Development;Disease;Disinhibition;Down-Regulation;effective therapy;Effectiveness;Electrophysiology (science);Ethanol;Ethanol Metabolism;Etiology;experimental study;Female;Functional disorder;Gene Expression;gene network;Genetic;Goals;heuristics;Histologic;Histological Techniques;Hypothalamic structure;Immunohistochemistry;Injections;innovation;Intake;Intervention;Knowledge;male;Mediating;Metabolism;Methodology;Modeling;Molecular;Motivation;mRNA Expression;Nervous System Physiology;Neurons;Nonpharmacologic Therapy;novel;novel strategies;Operative Surgical Procedures;Oral;Oxytocin;paraventricular nucleus;Pathway interactions;Patients;Peripheral;Peripheral Nervous System;pharmacologic;Play;pre-clinical;preference;preventable death;Property;Rattus;Regulator Genes;Relapse;relapse risk;Research;restoration;Rewards;Risk;Rodent Model;Role;selective expression;Self Administration;Signal Transduction;Stomach;Stress;Surgical Models;System;Techniques;Testing;Tissues;Transgenic Organisms;translational study;treatment strategy;Vagotomy;Vagus nerve structure;Viral

PROJECT_TITLE: Vagal-hypothalamic modulation of alcohol intake

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ORG_CITY: CLEVELAND

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative We request funding to purchase a new nanoScan SPECT-CT scanner. This proposed micro-scanner will restore the preclinical SPECT-CT capability in the region since failure of our last system before the pandemic and will provide basic science SPECT-CT radionuclide imaging for 20 major users spanning a broad range research programs including: the development of novel theranostic agents aimed towards personalized medicine, exciting and highly impactful immunotherapy strategies, as well as novel research in cancer, cystic fibrosis, digestive diseases, inflammation and infection, and tissue repair and regenerative medicine.

PI_NAMEs: LEE, ZHENGHONG  (contact)

PROJECT_TERMS: Advisory Committees;Animal Disease Models;Animal Model;Animals;Anti-viral Therapy;Area;Basic Science;Callithrix;Clinical Sciences;Collimator;Communicable Diseases;Comprehensive Cancer Center;Computer software;cost;Cystic Fibrosis;detector;Development;Digestive System Disorders;experience;Faculty;Failure;Ferrets;Image;Image Analysis;image visualization;Immunotherapy;Institution;Licensing;manufacture;microSPECT;Monitor;National Center for Advancing Translational Sciences;National Institute of Diabetes and Digestive and Kidney Diseases;novel;novel therapeutic intervention;Ohio;Oryctolagus cuniculus;pandemic disease;Performance;policy recommendation;pre-clinical;programs;Radionuclide Imaging;Research;Research Personnel;respiratory;Rodent;Scanning;seal;single photon emission computed tomography;synergism;System;Temperature;theranostics;Time;Tissues;Translational Research;Universities;Woodchuck;X-Ray Computed Tomography

PROJECT_TITLE: MicroSPECT/CT to aid the development of theranostics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (31)]


ORG_CITY: MILWAUKEE

ORG_DEPT: BIOPHYSICS

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE A modern Bruker ELEXSYS-II E500 X-band CW (continuous wave) EPR (electron paramagnetic resonance) spectrometer system is requested to replace an outdated and frequently malfunctioning version in the National Biomedical EPR Center at MCW. The enhanced sensitivity and reliability of the new instrument will significantly improve our ability to study critical biological phenomena including protein structure and functional dynamics, mechanisms of novel redox and cancer therapeutic agents, and aid in the design of safer and more effective drugs against a broad spectrum of diseases. This state-of-the-art instrument will ensure the continued success of our NIH-funded research programs while also facilitating new scientific collaborations.

PI_NAMEs: KLUG, CANDICE S (contact)

PROJECT_TERMS: Biology;Communities;design;digital;Digital Signal Processing;drug discovery;Electron Spin Resonance Spectroscopy;Enzymes;Funding;Future;Grant;improved;instrument;Investigation;medical schools;Membrane;microwave electromagnetic radiation;Minor;Modernization;Noise;Oxidation-Reduction;Power Sources;programs;Reaction;Research;Running;Sampling;Scanning;solid state;Source;structural biology;success;System;Technology;technology development;Temperature;United States National Institutes of Health;Wisconsin

PROJECT_TITLE: Bruker ELEXSYS-II E500 X-band CW EPR spectrometer system

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-D (30)]


ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: The requested equipment will provide a much-improved means of creating thin sections from tissues containing bone, teeth and various biomaterials for examination in microscopes and other analytic instruments. Current methods for creating these sections have significant limitations, curbing scientific advances. Scientists using this equipment will develop improved understanding of diseases such as osteoporosis, osteoarthritis, rheumatoid arthritis, and osteodystrophy of chronic kidney disease. The equipment will also help to improve our understanding of biological processes underlying bone healing and tissue engineering. This knowledge will be important to improving public health.

PI_NAMEs: SUMNER, D RICK (contact)

PROJECT_TERMS: Academic Medical Centers;Advisory Committees;Biology;bone;Bone Diseases;Bone Growth;Bone Regeneration;Bone remodeling;Chicago;Decalcification;Degenerative polyarthritis;Dental;Effectiveness;Equipment;Extracellular Matrix;Fourier Transform;Funding;Goals;Grant;Health;Histologic;histological specimens;Histology;Home;Illinois;Image;Immunohistochemistry;Institution;instrument;Lasers;meter;Methods;microCT;Microtomy;mineralization;Minor;Morphologic artifacts;nanoindentation;North America;Plastic Embedding;Preparation;Process;Raman Spectrum Analysis;reconstruction;Research;Research Personnel;Sampling;Scanning Electron Microscopy;skeletal;Slide;System;Thinness;Tissue Engineering;Tissue Sample;Tissues;Tooth structure;Training;United States National Institutes of Health;Universities;Width;Work

PROJECT_TITLE: Acquisition of a laser microtomy system for hard tissue histology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (30)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Immunotherapy

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative MS4A family is poorly defined in the context of cancer immunity and immunotherapy. We will explore the expression, regulation, and role of MS4A family in the tumor microenvironment. The proposal will provide an opportunity to take our understanding of MS4A7 to a new level of mechanism and application.

PI_NAMEs: ZOU, WEIPING  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Affect;Animal Model;Antigen Presentation;Antigen-Presenting Cells;Bioinformatics;Biological;cancer immunotherapy;cancer type;CD86 gene;Characteristics;Classification;Clinical;colon cancer patients;Colorectal Cancer;Complex;Cues;Dendritic Cells;DNA Sequence Alteration;effector T cell;Elements;Endowment;Epigenetic Process;Family;Family member;Genes;Genetic;Genomics;Goals;Human;Immune;immune checkpoint blockade;Immune Evasion;immune resistance;Immunologic Sensitization;Immunologics;immunoregulation;Immunosuppression;Immunotherapy;Impairment;improved;insight;Integral Membrane Protein;Interferons;JAK1 gene;JAK2 gene;Lesion;Lung;Macrophage;Malignant Epithelial Cell;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mediating;Melanoma;member;Membrane;Membrane Proteins;Metabolic;MHC Class I Genes;Microsatellite Repeats;Molecular;Monoclonal Antibodies;Mus;Mutation;Myeloid Cells;neoplastic cell;neutralizing antibody;novel;Pathway interactions;Patients;PD-1 pathway;PD-1/PD-L1;Phagocytosis;Phenotype;Population;prevent;Primary carcinoma of the liver cells;programs;Proteins;Proteomics;Regulation;Resistance;resistance mechanism;response;Role;Shapes;Signal Pathway;Signal Transduction;Small Cell Carcinoma;Solid Neoplasm;success;System;T-Cell Activation;Testing;tool;trafficking;translational engagement;TREM2 gene;tumor;Tumor Escape;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages

PROJECT_TITLE: MS4A7 in tumor resistance to immunotherapy

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


PHR: Project Narrative As the third-largest private medical school in the nation, the Medical College of Wisconsin is committed to building a regional resource to support biomedical research in infectious diseases, cancer, diabetes, brain disorders, cardiovascular disease, and drug discovery. The Advanced Cell Imaging Core is a crucial part of this effort. Enhancing the access to the cutting-edge super-resolution imaging system requested in this application will contribute to the research programs funded by NIH and directly impact the missions of medical education and research in the College and its partner institutions in southeast Wisconsin.

PI_NAMEs: LOU, XUELIN  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Autophagocytosis;Cancer Biology;cell motility;Cells;Cellular biology;cellular imaging;Cellular Structures;Communities;Confocal Microscopy;Disease;Doctor of Philosophy;drug discovery;Endocrinology;experience;Funding;Grant;Health;Human;Image;imaging system;innovation;Institution;instrument;instrumentation;interest;Ion Channel;medical schools;Microbiology;Microscope;Microscopy;Mitochondria;Monitor;nanoscale;nanoscope;Nanostructures;Nerve Degeneration;Neurosciences;organ growth;programs;receptor function;Research;Research Personnel;Research Project Grants;Resolution;Signal Transduction;Structure;superresolution imaging;Synapses;System;Tissues;trafficking;ultra high resolution;United States National Institutes of Health;Universities;Wisconsin

PROJECT_TITLE: STED Super-resolution Imaging System


ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE  Intravital multiphoton microscopy has become a fundamental approach to investigate the single-cell interactions of the immune system in living tissues and living animals during steady-state conditions of normal health or during infection, transplantation, autoimmunity, cancer, and therapeutic approaches for these conditions. The requested multiphoton instrument will allow University of Minnesota Center for Immunology investigators to continue ongoing NIH-funded research unimpeded and allow them to significantly expand imaging-based research for the rational design of novel therapies in cancer, transplantation, autoimmunity, host/pathogen interactions, vaccines and infectious diseases.

PI_NAMEs: FIFE, BRIAN T (contact)

PROJECT_TERMS: 12 year old;Animals;Area;Autoimmunity;Biological;biomedical imaging;cell motility;cell type;Communicable Diseases;Data;data acquisition;Detection;Diagnosis;Discipline;Dyes;Ensure;Equipment;Faculty;Funding;Grant;Health;Human;human disease;Image;immune activation;Immunologist;Immunology;Individual;instrument;intravital imaging;intravital microscope;Knowledge;Malignant Neoplasms;Microscope;Minnesota;Minor;Molecular;Movement;multi-photon;multiphoton imaging;multiphoton microscopy;novel;Optics;pathogen;Penetration;prevent;Proteins;Public Health;repaired;Research;research faculty;Research Personnel;response;Signal Transduction;Specimen;System;Technology;Tissues;Transplantation;United States National Institutes of Health;Universities;Vaccine Design;Vendor

PROJECT_TITLE: Multiphoton microscope for intravital biomedical imaging.


ORG_CITY: PROVIDENCE

ORG_DEPT: BIOLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Signaling and coordination among organ systems provides functional balance in young, healthy adults. Such interorgan communication is disrupted in the process of aging and contributes to complex, multiorgan loss-of- function. This proposal studies how changes in the communication between the kidney, adrenal gland and heart contributes to age-associated renal and cardiac decline.

PI_NAMEs: GONG, RUJUN ;TATAR, MARC  (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Acceleration;Adrenal Glands;adrenal transplantation;Adult;Affect;Age;age related;Age related pathologies;aged;Aging;aging process;aging related;Aldosterone;Angiotensins;Body System;Cardiac;cardiac aging;Cardiac Myocytes;Cardiorenal syndrome;cofactor;Communication;comorbidity;Complex;coronary fibrosis;Data;Dehydration;design;disability;Drosophila genus;Ecdysone;Elements;Epidermal Growth Factor Receptor;Equilibrium;experience;Extracellular Matrix;Feedback;Fibroblasts;Fibrosis;Fostering;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gender difference;genetic manipulation;Heart;hemodynamics;Heterogeneity;Heterozygote;Histologic;Homeostasis;Hormonal;Hormones;Human;juvenile animal;Kidney;kidney dysfunction;Kidney Transplantation;loss of function;Mammalian Cell;Mammals;Measures;Mediating;Membrane;Mineralocorticoid Receptor;Modeling;Morbidity - disease rate;mortality;Mus;Myocardial dysfunction;Natriuretic Peptides;novel;Nuclear;old mice;Older Population;Organ;Phosphotransferases;Physiological;Physiological Processes;receptor;Receptor Signaling;Renin;response;Role;Sarcoma;Signal Transduction;Sodium Chloride;steroid hormone;Steroids;Stress;System;Testing;Tissues;Transactivation;Transplantation;Water

PROJECT_TITLE: Age remodels kidney-adrenal-heart interorgan communication


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Neurosciences;Sleep Research

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative The overall objective of the proposed research is to elucidate molecular mechanisms regulating the circadian expression of ion channel transcripts and proteins that impact arrhythmia susceptibility. To do this we will apply contemporary genomic, biochemical, and molecular tools to interrogate the circadian regulation of myocardial ion channel transcription and translation in cardiomyocytes. We will complement these studies by using electrophysiology approaches that allow us to determine whether feeding behavior can be manipulated as a chronotherapeutic strategy to ameliorate the risk for cardiac arrhythmias.

PI_NAMEs: DELISLE, BRIAN P (contact);SCHRODER STUMPF, ELIZABETH A

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Address;Adopted;Affect;ARNTL gene;Arrhythmia;Autonomic nervous system;Behavior;Behavioral;Biochemical;Biological Assay;Bioluminescence;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;Cardiovascular Diseases;chromatin immunoprecipitation;Chronobiology;circadian;circadian pacemaker;circadian regulation;Circadian Rhythms;Complement;Cues;Darkness;Data;Development;Electrophoretic Mobility Shift Assay;Electrophysiology (science);Environment;environmental change;Fasting;feeding;Feeding behaviors;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic Transcription;Genomics;Heart;Impairment;in vivo;Individual;insight;Ion Channel;Ion Channel Protein;Knock-out;Knockout Mice;Knowledge;Laboratories;Light;Mediating;Messenger RNA;Molecular;mouse model;mRNA sequencing;multiple datasets;Mus;Myocardial;novel;Periodicity;Persons;Pharmaceutical Preparations;Physiological;Physiology;Play;Predisposition;Process;promoter;Proteins;Refractory;Regulation;Regulator Genes;Regulatory Element;Research;Research Proposals;ribosome profiling;Risk;Role;Signal Transduction;sudden cardiac death;suprachiasmatic nucleus;Technology;Telemetry;Time;Time-restricted feeding;Tissues;tool;Transcript;transcription factor;Transcriptional Regulation;Translational Regulation;Translations;translatome;Ventricular;Vulnerable Populations

PROJECT_TITLE: Circadian Regulation of Cardiac Electrophysiology

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The proposed research is relevant to public health because autoimmune and inflammatory kidney diseases are a significant cause of morbidity and mortality in affected patients. Standard immunosuppressive drugs are not effective in many patients, and the drugs themselves are associated with significant side effects. The concepts tested in these experiments should offer an important new approach to treating these diseases.

PI_NAMEs: HOLERS, VERNON MICHAEL;THURMAN, JOSHUA M (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Address;Affect;Alternative Complement Pathway;Animal Model;Antibodies;Antigens;Area;Autoantibodies;Autoantigens;Autoimmune;Autoimmunity;Binding;Blood;Cell surface;Cells;Chromosome 1;Complement;Complement 3d Receptors;Complement Activation;Complement Factor H;Complement Inactivators;complement system;Complex;Development;Disease;experimental study;Family;Gene Proteins;Genes;genetic regulatory protein;genetic variant;Glomerulonephritis;Hemolytic-Uremic Syndrome;Heterozygote;Human;human disease;human model;imaging modality;Immune;Immune response;Immunosuppressive Agents;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Injury;Injury to Kidney;innovation;interstitial;Intervention;Kidney;Kidney Diseases;Knowledge;Laboratories;Link;Liquid substance;Location;Maps;Mediating;Mediator;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mus;Mutation;natural antibodies;novel;novel strategies;novel therapeutics;Pathogenicity;Pathway interactions;Patients;PF4 Gene;Pharmaceutical Preparations;Phase;Plasma Proteins;Play;Productivity;Prognosis;protein complex;Protein Deficiency;Protein Family;Protein Region;Proteins;Public Health;Reagent;Recombinants;Recording of previous events;Renal glomerular disease;Research;Research Design;Role;side effect;Site;Surface;Sushi Domain;targeted treatment;Testing;Therapeutic;Tissues;tool;Uncertainty;Variant

PROJECT_TITLE: Role of the Factor H Related Proteins in Kidney Disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dissemination and Implementation Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD)

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

PHR: Project Narrative This study will refine and test automated quality coding of exposure therapy, a highly effective treatment for anxiety across the lifespan, using data from 6 existing clinical trials for youth and adults, across both research and community settings. Specific aims are designed to validate automated coding with Natural Language Processing (NLP; a type of artificial intelligence) against human coders, test predictive utility, and incorporate stakeholder feedback to facilitate near-term usability of findings.

PI_NAMEs: BENITO, KRISTEN G (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Acceleration;Address;Adherence;Adult;Aftercare;Age;Agreement;Anxiety;anxiety treatment;Area;Artificial Intelligence;care outcomes;Classification;Clinical;clinical care;Clinical Trials;Code;Cognitive Therapy;Communities;community setting;cost;Data;Data Set;deep learning;design;Diagnosis;effective therapy;Empathy;Ethnic Origin;Evidence based intervention;Exposure to;Family;Feedback;Future;Gender;Goals;health care availability;Human;implementation efforts;implementation tool;improved;Incentives;innovation;International;Laboratories;life span;Manuals;Measurement;Measures;Mental Health Services;Methods;Mission;Modeling;Monitor;National Institute of Mental Health;Natural Language Processing;novel;Outcome;patient subsets;Patients;Policy Maker;practice setting;Predictive Value;Procedures;Process;prototype;Provider;Psychotherapy;Public Health;Race;Randomized;Randomized, Controlled Trials;Research;Research Personnel;research study;Sampling;Service setting;Severities;Small Business Innovation Research Grant;standard measure;Strategic Planning;Techniques;Technology;Testing;theories;tool;Training;Translations;usability;Validation;Work;Youth

PROJECT_TITLE: Automated Coding of Exposure Therapy Quality using Natural Language Processing

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Hematology

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE: This project will apply a novel in vivo gene editing approach to reveal key mechanistic drivers that perturb blood cell function with age and directly test the relevance of mutations that arise in cells of the blood system and can drive the expansion of individual blood cell clones to age-related dysfunctions in the cardiovascular, neurologic and skeletal muscle systems.

PI_NAMEs: WAGERS, AMY JO (contact)

PROJECT_TERMS: Affect;Age;age difference;age effect;Age of Onset;age related;age related changes;Age related pathologies;age-related disease;Aging;aging related;Animals;Biological Assay;biological sex;Blood;Blood Cells;Body System;Brain;Cardiac;Cardiovascular system;Cell Lineage;Cell Physiology;cell type;Cells;Clinical;Clonal Expansion;Clonality;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Cre lox recombination system;Data Set;Dependence;Development;Disease;Disease susceptibility;DNA Sequence Alteration;driver mutation;drivers of aging;Elderly;Event;Exhibits;experimental study;Functional disorder;gene editing technology;Gene Expression Profiling;Gene Targeting;gene-editing approach;Genes;Goals;Heart;Hematopoiesis;Hematopoietic;Hematopoietic System;Human;human data;human very old age (85+);Immune system;Immune System Diseases;Impaired cognition;In Situ;in vivo;Individual;insight;Link;Macrophage;Mediator;Molecular;Monitor;monocyte;Mus;Muscle;muscular system;Musculoskeletal;Mutagenesis;mutant;Mutate;Mutation;mutational status;Neurologic;novel;Organ;Outcome;Parabiosis;Pathologic;Pathology;Pathway interactions;Penetrance;Phenotype;premature;Prevalence;prevent;Production;Property;Proteome;Relative Risks;Risk;Role;Serum;Severities;Signal Transduction;single cell sequencing;Skeletal Muscle;Somatic Mutation;Specificity;System;T-Lymphocyte;Testing;therapeutic target;Time;Tissues;Transgenes;Virus;Work

PROJECT_TITLE: Disrupted Communication Between Blood Cells and Non-blood Organs as a Mediator of Aging Pathologies


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Human Cytomegalovirus (HCMV) is a major cause of permanent neuronal damage in thousands of infants in the United States every year and causes significant disease and death in individuals with weakened immune systems, including transplant recipients and some cancer patients. Cytokines are cellular signaling molecules that induce an anti-viral state to limit viral infection. Our proposal focuses on two opposing sides of the anti- viral state that could determine infectious outcomes: one, elucidating how cytokines reprogram metabolism to limit viral infection; and two, identifying the mechanisms through which the HCMV antagonizes anti-viral signaling.

PI_NAMEs: MUNGER, JOSHUA C (contact)

PROGRAM_OFFICER_NAME: PARK OCHSNER, SUSAN SOO

PROJECT_TERMS: Address;Affinity;antagonist;Anti-viral Response;Back;Binding;Biology;Cancer Patient;Carbon;cell type;Cells;Cellular Metabolic Process;Cessation of life;combat;Complex;Congenital Abnormality;cytokine;Cytokine Signaling;Cytomegalovirus;Cytomegalovirus Infections;Data;Disease;Dissection;experimental study;Failure;Gene Expression;Genes;Genetic;Glycolysis;Glycolysis Induction;Human;Immune;Immune signaling;Immune system;Immunity;Immunocompromised Host;Individual;Infant;Infection;Inflammatory;inhibitor;Interferon alpha;Interferon Type II;Interferons;Libraries;Life Cycle Stages;Mediating;Metabolic;Metabolic Activation;Metabolic Pathway;Metabolism;Modeling;Morbidity - disease rate;Neurons;NF-kappa B;novel;Nuclear;Outcome;Pathogenesis;Pathology;patient population;Phosphorylation;prevent;Production;programs;protein inhibitors of activated STAT;Proteins;Proteomics;Regulation;Research;Side;Signal Pathway;Signal Transduction;Signaling Molecule;STAT protein;success;Sumoylation Pathway;Testing;TNF gene;transcription factor;Transplant Recipients;ubiquitin-protein ligase;United States;Viral;Viral Genes;Viral Pathogenesis;Viral Physiology;Viral Proteins;Virion;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Metabolism and HCMV: determinants of the antiviral state

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Although mammalian species display significant variation in the rate of embryonic development, the mechanisms that define species-specific developmental rates remain unknown. The proposed research program will leverage in vitro models of mouse and human development to define the role of mitochondrial metabolism in regulating developmental speed. Elucidating the mechanisms that control developmental rate will enable its direct manipulation, making possible the acceleration of human induced pluripotent stem cell differentiation for disease modeling and cell-based therapies.

PI_NAMEs: DIAZ CUADROS, MARGARETE  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Acceleration;Address;Affinity;aging process;Asian Americans;Basal metabolic rate;Biogenesis;Biological Assay;Black race;cancer cell;career;career development;Cattle;Cell Therapy;cell type;Cells;cohort;Communities;Conserved Sequence;Creativeness;Data;Deceleration;Dedications;density;design;Development;Developmental Biology;disease model;diversity and inclusion;Educational workshop;Elephants;Embryo;embryo cell;Embryonic Development;Environment;Equity;Event;faculty mentor;FASTK Gene;Fostering;Gene Expression;General Hospitals;Generations;Genes;Goals;Growth;Human;Human Development;human induced pluripotent stem cells;human pluripotent stem cell;improved;In Vitro;in vitro Model;Institution;Institutional Racism;Knowledge;Latinx;Lesbian Gay Bisexual Transgender Queer;life span;Longevity;Low income;Macaca mulatta;Mammals;marginalization;Massachusetts;Measures;member;Mentorship;Mesoderm;Mesoderm Cell;Messenger RNA;metabolic rate;Metabolism;Minority;Mitochondria;mitochondrial metabolism;Modeling;Molecular;Molecular Biology;mouse development;Mus;Nuclear Export;Pacific Islander;Pathway interactions;Periodicity;Persons;placental mammal;pluripotent stem cell differentiation;post-doctoral training;Postbaccalaureate;Production;programs;Proliferating;Proteins;Proxy;Publishing;Rattus;recruit;Regulation;Research;Research Personnel;Resolution;Resources;Respiration;RNA Splicing;Role;Science;Segmentation Clock Pathway;Sexism;single-cell RNA sequencing;Somites;Speed;stem;summer research;System;Testing;Tissue-Specific Gene Expression;Training;transcriptome;tumor growth;Tupaiidae;Underrepresented Populations;Variant;Work

PROJECT_TITLE: Role of Mitochondrial Metabolism in Regulating Species-Specific Developmental Rates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-G (56)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Opioids;Rehabilitation;Substance Misuse

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative Alcohol consumption stimulates the release of endogenously-produced opioid peptides that influence the rewarding effects of this drug. With continued consumption and over time, the ability to stimulate the same level of response changes fundamentally, although it is not known if such changes include the production of novel peptides from the same family. Here we will apply the use of advanced analytical platforms and animal models of addiction towards the study of a novel peptide that we believe may be influencing cognitive impairments in individuals with Alcohol Use Disorder.

PI_NAMEs: NATIVIDAD, LUIS ALBERTO (contact)

PROJECT_TERMS: Abstinence;Acute;addiction;Address;Adherence;advanced analytics;Agonist;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol use disorder;Alcohols;Animal Model;antagonist;Area;Attenuated;Behavior;Behavioral;Binding;Brain;Chronic;Clinic;Clinical;clinical efficacy;Cognition;Cognitive;cognitive function;Cognitive Therapy;Complex;Consumption;Coupled;Data;Dependence;desensitization;Dialysis procedure;Drug Metabolic Detoxication;druggable target;endogenous opioids;Enkephalins;Environment;Exhibits;experience;Family;flexibility;frontal lobe;Functional disorder;gamma-Aminobutyric Acid;Glutamates;Goals;Impaired cognition;Impairment;improved;in vivo;Individual;Influentials;insight;Interneurons;Knowledge;Laboratories;learned behavior;Lesion;Ligands;long term abstinence;Mass Spectrum Analysis;Medial;Mediating;Methionine Enkephalin;Methods;Microdialysis;Modality;Modeling;Molecular;Monitor;Motivation;neuroadaptation;neurochemistry;Neurons;Neuropeptides;neurotransmission;novel;Opioid;Opioid Antagonist;Opioid Peptide;Opioid Receptor;Pathology;Patients;Pattern;peptide B;Peptides;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacy (field);Phenotype;Phosphorylated Peptide;Phosphorylation;Play;preclinical study;Prefrontal Cortex;preservation;Process;Production;proenkephalin;Property;Protein Precursors;Rattus;receptor;Receptor Activation;receptor binding;Receptor Signaling;Recovery;Regulation;response;Rewards;Role;Signal Transduction;success;Task Performances;Time;transmission process;treatment adherence;Withdrawal;Work

PROJECT_TITLE: Examining the role of novel proenkephalin peptides in influencing alcohol-induced cognitive dysfunction

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Two decades-old transmission electron microscopes at Vanderbilt University, that have been used extensively and essential to identifying optimal specimens for high-resolution structural determination by electron cryo-microscopy (cryo-EM), are no longer repairable. To replace these instruments with a modern technology, we propose to acquire the ThermoScientific Talos L120C at our cryo-EM facility. Structural determination of biological macromolecules and cellular ultrastructure at high-resolution by cryo-EM is central to elucidating the physiological and disease mechanisms at the molecular level, and thus acquisition of the proposed instrument is expected to support the continued progress and acceleration of NIH funded research projects of investigators at Vanderbilt University that are highly relevant to improving human health.

PI_NAMEs: NAKAGAWA, TERUNAGA  (contact)

PROJECT_TERMS: Address;Biological;biological systems;Biology;Biomimetics;Calcium Signaling;Cells;college;Complex;computerized data processing;Core Facility;cost;Costs and Benefits;Cryo-electron tomography;Cryoelectron Microscopy;cryogenics;detector;Development;DNA biosynthesis;Electron Microscope;Funding;G-Protein-Coupled Receptors;Health;Homeostasis;Hour;Human;Image;improved;in silico;In Situ;Investigation;Ion Channel;Ligands;Lipids;macromolecule;Measurement;Membrane;Membrane Proteins;Modernization;Molecular;Molecular Conformation;mRNA Export;Negative Staining;neurotransmission;novel;Nuclear Export;particle;pathogen;Pathologic;Physiological;Polymers;Process;Protein Subunits;Proteins;repaired;Research Personnel;Resolution;Sampling;Schools;screening;simulation software;Specimen;Synapses;Technology;Temperature;Therapeutic;Therapeutic antibodies;Titan;trafficking;transmission process;United States National Institutes of Health;Virus Assembly;Visualization

PROJECT_TITLE: TFS Talos-L120C, a 120kV transmission electron microscope for structural studies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-B (30)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research;Wound Healing and Care

ORG_CITY: WASHINGTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE Our prior studies demonstrated efficacy of adjunctive azithromycin to further reduce maternal infections by 50% and remarkable cost-savings in unscheduled cesareans (CDs), leading ACOG to recommend its routine use in unscheduled CDs. Given additional promising preliminary data, we propose a large randomized trial (N=8000) within the MFMU Network to evaluate the benefits of adjunctive azithromycin in scheduled/pre-labor CDs and further assess the safety of this innovative antibiotic prophylaxis strategy to reduce the incidence of infection, one of the top 3 causes of pregnancy-related death and illness in the US. The trial will likely lead to a rapid policy change to extend this promising intervention to scheduled CDs, with significant health and cost benefits.

PI_NAMEs: BOGGESS, KIM A;CLIFTON, REBECCA GERSNOVIEZ (contact);TITA, ALAN THEVENET N.

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Admission activity;Adverse event;Allergic;American College of Obstetricians and Gynecologists;Anaerobic Bacteria;Antibiotic Prophylaxis;Antibiotic Therapy;Antibiotics;Azithromycin;Biological;Biological Markers;Cardiopulmonary Resuscitation;Cefazolin;Centers for Disease Control and Prevention (U.S.);Cephalosporins;Cesarean section;Cessation of life;Clinic Visits;Closure by clamp;Concept Review;cost;Cost Analysis;cost effective;Cost Savings;Costs and Benefits;Data;design;Dose;Endometritis;Equipoise;Future;Guidelines;Health;Health Benefit;Health Care Visit;Healthcare;hospital readmission;Hour;Hypertrophic Pyloric Stenosis;Incidence;Infant;Infection;infection rate;infection risk;innovation;interest;Intervention;Intravenous;Knowledge;Length of Stay;Maternal Mortality;maternal safety;Maternal-Fetal Medicine Units Network;Mediating;Membrane;Microbe;microbiome;microbiome analysis;microbiome specimens;Nasopharynx;National Institute of Allergy and Infectious Disease;Necrotizing fasciitis;Neonatal;Neonatal Intensive Care Units;neonatal morbidity;Newborn Infant;Operative Surgical Procedures;Organism;Outcome;pathogen;Patients;Perinatal;Perinatal Exposure;perinatal outcomes;Placebos;Policies;postcesarean section;Postpartum Period;predictive marker;pregnancy related death;pregnant;prevent;Prophylactic treatment;Randomized;randomized trial;randomized, clinical trials;Recommendation;Rectum;Relative Risks;Resistance;Resources;Risk Reduction;Rupture;Safety;safety assessment;Schedule;Sepsis;Seroma;Site;Specimen;Surgical incisions;Surgical Wound Dehiscence;Surgical Wound Infection;Surveys;Testing;Umbilical Cord Blood;Umbilical cord structure;Uncertainty;Ureaplasma;Vaginal delivery procedure;Woman;wound;Wound Infection

PROJECT_TITLE: Adjunctive Azithromycin Prophylaxis for Scheduled/Prelabor Cesarean Delivery

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-C (55)]


ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE This application seeks funds for a state-of-the art, hybrid quadrupole-Orbitrap (IQ-X) high resolution mass spectrometer to be housed within an existing core facility at the University of South Florida (USF). The instrument will be dedicated to establishing a Nucleic Acid Adductomics capability as a campus-wide shared resource to support multiple NIH-funded projects across USF and Moffitt Comprehensive Cancer Center. This will provide a unique approach to characterizing the widest possible range of nucleic acid modifications, and hence advancing our knowledge of their role in health and disease.

PI_NAMEs: COOKE, MARCUS STANLEY (contact)

PROGRAM_OFFICER_NAME: CHEN, YONG

PROJECT_TERMS: Acceleration;adduct;Arts;Award;Biological;Biological Markers;carcinogenesis;Cardiovascular Diseases;Chemicals;college;Communicable Diseases;Complex;Comprehensive Cancer Center;Dedications;Disease;DNA;drug discovery;Extracellular Matrix;Florida;Funding;Genome;Genomic Instability;Health;improved;Individual;innovation;instrument;mass spectrometer;Measurement;Medicine;Mitochondria;Modification;Nervous System Disorder;Noise;Nuclear;Nucleic Acids;Pathogenesis;Performance;Principal Investigator;programs;protein crosslink;Proteins;Proteomics;Public Health;Research;Research Personnel;Resolution;Resource Sharing;Respiration Disorders;RNA;Role;Sampling;Scanning;Science;small molecule;Structure;System;Taiwan;Technology;Time;United States National Institutes of Health;Universities;Urine

PROJECT_TITLE: Aquisition of a Orbitrap IQ-X Mass Spectrometer System with Vanquish Flex UHPLC System for Nucleic Acid Adductomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-T (30)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Mental Health;Neurosciences;Stroke

PHR: PROJECT NARRATIVE/RELEVANCE Poor neurocognitive outcome in survivors of subarachnoid hemorrhage is an important problem affecting over 30,000 Americans each year. Dr. Chung's proposal has great potential to advance the understanding of poor neurocognitive outcome in this patient population through understanding how subarachnoid hemorrhage alters resting state functional brain connectivity. Furthermore, Dr. Chung seeks to develop a brain stimulation paradigm to restore cognitive function after brain injury.

PI_NAMEs: CHUNG, DAVID YOUNG (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: 3-Dimensional;Acute Brain Injuries;Affect;American;Aneurysmal Subarachnoid Hemorrhages;Behavior;Behavior assessment;Behavioral;Biological Markers;Blood Vessels;Brain;Brain Aneurysms;Brain Injuries;Calcium;Caring;cerebrovascular;Climacteric;Clinical Management;Cognition;Cognitive;Cognitive deficits;cognitive function;Corpus Callosum;cost;density;design;Diffusion Magnetic Resonance Imaging;Disease;disease model;Dorsal;effective therapy;executive function;Fluorescence;Functional disorder;Functional Magnetic Resonance Imaging;functional restoration;Genetic;Goals;hemodynamics;Human;Impairment;improved;in vivo;Inflammatory;Injury;insight;Learning;Magnetic Resonance Imaging;Magnetoencephalography;Maps;Measurement;Memory;Molecular;mouse model;multidisciplinary;Mus;network dysfunction;Neurocognitive;Neurocognitive Deficit;neuronal cell body;neuronal circuitry;Neurons;neurovascular coupling;novel therapeutics;optical imaging;Optical Methods;optogenetics;Outcome;patient population;Performance;Persons;pre-clinical;preservation;prevent;Publishing;Quality of life;reconstitution;Reporting;Resolution;Rest;Rodent;Role;Rupture;Ruptured Aneurysm;Signal Transduction;spatial memory;Stroke;Subarachnoid Hemorrhage;Surface;Survivors;System;Testing;therapeutic target;Time;way finding;white matter;Work

PROJECT_TITLE: Brain Stimulation to Improve Neurocognitive Deficits After Subarachnoid Hemorrhage

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: MADISON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative  Acquisition and installation of a Waters UPC2-MS instrument will enable scientists to characterize diverse new molecules derived from innovative synthetic methodology efforts at UW-Madison. The research targets medicinally relevant building blocks and complex molecules with increased structural diversity and stereochemical density. The requested instrument has state-of-the art resolving powers for chiral and achiral molecules, coupled to robust optical and mass detectors to support rapid assays needed to support high- throughput synthesis and screening. The research supported by this instrument will elucidate new ways to probe bacterial cell-cell signaling, discover novel disease therapies, and develop new catalytic methods for pharmaceutical synthesis.

PI_NAMEs: HEINS, SPENCER  (contact)

PROJECT_TITLE: Acquisition of a Supercritical Fluid Chromatography Mass Spectrometer System


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: RICHMOND

ORG_DEPT: PSYCHIATRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE  Through the creation of an interactive, dynamic, and evidence-based repository, the National Coordinating Center for Advancing Gender Inclusive Excellence (AGIE) at Virginia Commonwealth University (VCU) will dramatically improve access to resources, tools, technologies, expertise, and strategies that address challenges in overcoming systemic gender-based inequities impacting the biosciences academic and research workforce. Using a multi-pronged dissemination strategy along with a Pilot and Feasibility Program, the VCU AGIE will leverage the extensive network of the leadership team in collaboration with the National Institutes of Health (NIH) to promote and expand this repository across the national stage to have a broad impact on the success of gender equity programs in the science, technology, engineering, mathematics, and medicine (STEMM) academic and research workforce. In collaboration with the NIH, the VCU AGIE will operate as a centralized hub for optimizing the success of gender equity programs, setting a national standard of excellence for advancing diverse women faculty into leadership positions across the STEMM fields.

PI_NAMEs: BOYAN, BARBARA D.;KORNSTEIN, SUSAN G. (contact);SUBRAMANIAM, MANGALA

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Address;Assessment tool;Automobile Driving;Biological Sciences;Biomedical Research;Collaborations;college;Common Data Element;Communication;Complex;Consultations;Data Collection;data repository;design;Development;Discipline;dissemination strategy;Ensure;equity, diversity, and inclusion;evidence base;Faculty;Foundations;Gender;gender equity;Goals;higher education;Improve Access;Inequity;innovation;Institution;Intervention;Leadership;Marketing;Modeling;Outcome;outcome disparities;Positioning Attribute;primary outcome;Process;programs;Recommendation;recruit;repository;Research;Resource Sharing;Resources;Science;science, technology, engineering, mathematics, and medicine;Self Assessment;shared repository;success;sustainable resource;symposium;Techniques;Technology;tool;Training;United States National Institutes of Health;Universities;Validity and Reliability;Virginia;Woman;women faculty

PROJECT_TITLE: VCU National Coordinating Center for Advancing Gender Inclusive Excellence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-Z (50)]


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Neurosciences;Nutrition;Osteoporosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE – RELEVANCE TO PUBLIC HEALTH The individual and financial burden of bone loss and deterioration during normal or premature drug-induced aging is immense, especially for women. Our team is creating new ways to therapeutically target bone loss after discovering that the homoeostatic control center of the brain makes and secretes a circulatory anabolic factor in mice that preserves bone density and strength during aging.

PI_NAMEs: INGRAHAM, HOLLY A. (contact)

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: Acceleration;Adipocytes;age related decline;Age-Related Bone Loss;aged;Aging;Anatomy;Anterior Hypothalamus;Bar Codes;Biological Assay;Biological Models;Blood Vessels;bone;Bone Density;Bone Diseases;bone loss;bone mass;bone preservation;bone strength;Brain;Calcium;Cell Separation;Cells;Cellular Assay;clinical practice;Code;Communication;Complex;Consumption;CRISPR interference;Cues;Data;Deterioration;Diet;dietary;differentiation in vitro;Dose;Ectopic Expression;Estrogens;Exposure to;Fatty acid glycerol esters;Female;Fibrous capsule of kidney;Financial Hardship;gain of function;genetic approach;Genomic approach;Goals;Health;High Fat Diet;Homeostasis;Human;Hypothalamic structure;improved;In Vitro;in vivo;in vivo Model;Individual;insight;Insulin-Like Growth-Factor-Binding Proteins;knock-down;Lead;Ligands;Liver;loss of function;male;Maps;Mediating;Metabolic Diseases;Methods;Modeling;Molecular;Molecular Profiling;mouse model;Mus;mutant;mutant mouse model;Nature;Neuroendocrinology;Neurons;Neurosecretory Systems;novel;NPAS4 gene;old mice;Organ;osteochondral tissue;Osteogenesis;osteogenic;Output;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;pre-clinical;preclinical study;premature;programs;Property;Protein Engineering;protein purification;Protein Secretion;Public Health;Recombinants;Rejuvenation;Research;Resolution;response;Role;Signal Transduction;single-cell RNA sequencing;skeletal;skeletal disorder;skeletal stem cell;Small Interfering RNA;stem cell biology;stem cell derived tissues;stem cell differentiation;stem cell function;Structure;Structure of nucleus infundibularis hypothalami;substantia spongiosa;suprachiasmatic nucleus;Testing;therapeutic target;Time;Tissues;transcription factor;Translating;Transplantation;Variant;Viral;Viral Vector;Wild Type Mouse;Woman;Work

PROJECT_TITLE: Rejuvenating Skeletal Health Through A Novel Brain-Bone Axis

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-P (J2)]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative: We present an urgent request for funding to purchase a new EchoMRI to replace the existing outdated analyzer which is obsolete in both hardware and software and suffers from frequent and unpredictable malfunctions that cause frustrating disruptions, delays and data loss to OHSU investigators engaged in NIH-funded studies.The new device will solve the current study disruption/delay issues and provide a reliable source of important technical services to ensure smooth progress of NIH-funded studies at OHSU to which body composition data are of critical importance. With advanced technology, enhanced capabilities, and improved accuracy, the new analyzer will revolutionize our research capabilities by offering expanded measurement capabilities, broader test modalities, and increased accuracy. This significant upgrade will unlock new dimensions and research areas that were previously unattainable due to limitations imposed by the outdated analyzer, enabling us to explore new frontier s and make groundbreaking discoveries.

PI_NAMEs: NIE, ZHENYING  (contact)

PROJECT_TERMS: 16 year old;Address;Animals;Applications Grants;Biomedical Research;Body Composition;Chronic Disease;Computer software;cost;Data;Development;Disease;Disease Progression;empowerment;Endocrinology;Ensure;Funding;Generations;Health;improved;Institution;instrument;instrumentation;Investigation;Investments;juvenile animal;Manufacturer;Measurement;Metabolic;Metabolic Diseases;Modality;Monitor;operation;Outcomes Research;Pathogenesis;programs;Research;Research Personnel;Resource Sharing;Safety;Secure;Testing;Time;United States National Institutes of Health;Universities;Vendor

PROJECT_TITLE: Shared Instrumentation Grant application for EchoMRI whole body composition analyzer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-M (30)]


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative This proposal requests funding for the Nanoscribe Quantum X Shape 3D Microfabrication System to support NIH-funded projects and drive advancements in medical optics, microfluidics, life sciences, and related health fields. The acquisition of this state-of-the-art instrument will have a substantial impact on ongoing research, enabling investigators to expand their capabilities, foster innovative research in biomedical technologies, and accelerate the translation of biomedical discoveries into practical clinical applications.

PI_NAMEs: LIANG, RONGGUANG  (contact)

PROJECT_TERMS: 3-Dimensional;Area;Arizona;Biocompatible Materials;Biological Sciences;biomedical imaging;Biomedical Research;Clinical;college;Dedications;design;Devices;Drug Delivery Systems;Elements;empowerment;Engineering;Equipment;fabrication;Funding;Future;Glass;Goals;Mechanics;meter;Microfabrication;Microfluidic Microchips;Microfluidics;nano;novel;optical imaging;Optics;Printing;prototype;quantum;Research;Research Personnel;Science;Shapes;success;System;Testing;United States National Institutes of Health;Universities

PROJECT_TITLE: Ultrahigh precision 3D microfabrication system for biomedical optical imaging and microfluidic system


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: 8. Project Narrative The purpose of this High-End Instrumentation Grant Program (S10) Application is to request funds to purchase a Super Argus R6 small-animal PET (positron tomography tomography) and CT (transmission computed tomography) scanner for our Animal Imaging Core Facility. It will play a critical role in MSK’s pre- clinical/translational oncology research program. The long-term impact of such work is enormous - to cost- effectively accelerate anti-cancer drug discovery and thereby reduce the mortality, morbidity, and financial costs of cancer.

PI_NAMEs: ZANZONICO, PAT B (contact)

PROJECT_TERMS: Administrative Efficiency;Aging;animal imaging;Animals;Biodistribution;Biological Assay;cancer therapy;Computed Tomography Scanners;Computer software;Core Facility;detector;disabled;Disease;Funding;Genetic;imaging capabilities;Immune;Infrastructure;instrument;Intervention;Malignant Neoplasms;Manufacturer;Measures;Medical;Memorial Sloan-Kettering Cancer Center;meter;microCT;microPET;Mission;Modeling;Monitor;multimodality;Mus;Oncology;Pathway interactions;Performance;Positron-Emission Tomography;pre-clinical;pre-clinical research;Process;Productivity;programs;Radiation therapy;Rattus;repaired;Research;Resolution;Resources;response;Services;Solvents;stem cells;System;trafficking;translational oncology;Transmission Computed Tomography;tumor;Width;X-Ray Computed Tomography

PROJECT_TITLE: The Super Argus PET/CT 6R for Pre-clinical Oncology Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (31)]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Palliative Care

ORG_CITY: HOUSTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will develop and evaluate a novel, personalized therapeutic approach for the management of dyspnea, one of the most common and distressing symptoms in hospitalized patients with cancer. In this patient-centered clinical study, we will take advantage of the acute nature of dyspnea to conduct a series of time-limited trials that will determine the optimal dyspnea treatment modalities for each patient. This research program is relevant to the mission of the National Institutes of Health because effective management of dyspnea will ultimately help to improve quality of life for patients suffering from this devastating symptom.

PI_NAMEs: HUI, DAVID  (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Acute;acute symptom;Adherence;Adopted;Advanced Malignant Neoplasm;Adverse event;arm;associated symptom;Breathing;Cancer Patient;Cannulas;Characteristics;clinical practice;Clinical Research;Clinical Trials;comparative efficacy;Data;demographics;Devices;Distress;Dyspnea;Dyspnea Management;Eligibility Determination;evidence base;experience;expiration;Gases;Goals;health related quality of life;high risk;hospice environment;Hospitalization;Hospitals;Hour;Hypoxemia;Impairment;improved;individualized medicine;Informed Consent;innovation;insight;Institute of Medicine (U.S.);Intervention;Intervention Studies;Malignant Neoplasms;Methodology;Mission;Modality;Monitor;murine nodule inducing virus;Nature;Nose;novel;Numeric Rating Scale;Nurses;Oncology;Opioid;Outcome;Outcome Study;Outpatients;Oxygen;palliation;palliative;Participant;patient oriented;patient population;Patient Preferences;Patient-Focused Outcomes;Patients;Pattern;personalized strategies;personalized therapeutic;Physicians;preference;pressure;programs;Public Health;Quality of life;Randomized Controlled Clinical Trials;randomized trial;Reporting;Research;Research Design;Research Priority;respiratory;response;Series;standard of care;Structure;supplemental oxygen;Symptom Burden;Symptoms;Testing;Therapeutic;Therapeutic Effect;Therapeutic Trials;Time;treatment as usual;treatment response;trial design;United States Food and Drug Administration;United States National Institutes of Health;ventilation;Waiting Lists;Work of Breathing

PROJECT_TITLE: Strategies for Personalizing Oxygen and support Therapies for dyspnea in Oncology

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Aging;Biotechnology;Cardiovascular;Heart Disease;Infectious Diseases;Precision Medicine

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The addition of a SCIEX ZenoTOF 7600 microflow LC-MS system with tunable electron activation disassociation and much enhanced sensitivity will significantly enhance the funded research of 16 UAB investigators. Their research is being applied to many of the major health issues facing Americans – aging, Alzheimer disease, cancer prevention and therapy, cardiac and cardiovascular disease, cytomegaloviral infection and other infectious diseases, lung disease, precision medicine for childhood genetic disease, and psychostimulant abuse.

PI_NAMEs: BARNES, STEPHEN  (contact)

PROJECT_TERMS: 13 year old;Aging;Alabama;Alzheimer's Disease;American;Animal Model;Area;Businesses;cancer prevention;cancer therapy;Cardiovascular Diseases;Cells;Clinical;clinical center;Clinical Sciences;Communicable Diseases;Data;Department chair;design;Direct Costs;Dissociation;Drosophila genus;Educational workshop;Electrons;experience;Funding;Future;graduate student;Grant;Health;Heart Diseases;improved;Infection;Institute of Medicine (U.S.);instrument;instrumentation;Ions;lipidomics;Lipids;Lung Diseases;mass spectrometer;metabolome;metabolomics;Minor;Names;operation;Postdoctoral Fellow;precision medicine;Price;Recommendation;Research;Research Personnel;Research Support;Sampling;stimulant abuse;Structure;Students;System;Training;translational model;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Enhanced Metabolomics/Lipidomics with a SCIEX ZenoTOF 7600


ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Narrative The Translational Pathology Shared Resource (TPSR) Facility at the SKCC of TJU is one of the 8 NCI-supported Core Facilities dedicated to developing cutting edge research in histopathology technical support and service as well as molecular pathology and digital pathology services. The current autostainer is remarkably slow and lacks capabilities such as Multiplexed Immunohistochemistry/Immunofluorescence, In Situ Hybridization and TUNEL assays. We request fund to acquire a new DISCOVERY ULTRA automatic autostainer to overcome these limitations to help our NCI-funded Cancer Center to achieve its mission.

PI_NAMEs: YANG, HAIFENG  (contact)

PROJECT_TERMS: Accreditation;assay development;Back;Basic Science;biobank;Biological Assay;Biomedical Research;Cancer Center;Cancer Center Support Grant;Charge;Clinical Research;Clinical Trials;Compensation;Contract Services;Core Facility;cost;Dedications;Diagnostic;digital pathology;DNA;DNA Nucleotidylexotransferase;Elements;Faculty;flexibility;Funding;Grant;Heating;Histopathology;Hour;Human Resources;Immunofluorescence Immunologic;Immunohistochemistry;improved;In Situ Hybridization;Individual;instrument;Label;Laboratories;Manuals;manufacture;Medical;member;molecular pathology;National Cancer Institute;operation;Pathology;Patients;Preparation;Productivity;programs;Protocols documentation;rapid test;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;RNA;Sampling;Services;Slide;Stains;Testing;Transferase;Translational Research;United States National Institutes of Health

PROJECT_TITLE: A multiplex automatic autostainer at Jefferson

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-D (30)]


ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative: The requested instrument is a crucial tool needed by a large number of investigators in their research to understand and elucidate basic biological systems and ultimately, to create novel therapeutics against many diseases, including various types of cancers, brain injury, degenerative neurological disorder, immune system disorder, atherosclerosis, and liver disease.

PI_NAMEs: WANG, EXING  (contact)

PROJECT_TERMS: Accounting;Area;Atherosclerosis;Award;biological systems;Biomedical Research;Brain Injuries;Cancer Center;cancer type;cellular imaging;Confocal Microscopy;Core Facility;Discipline;Disease;Funding;Health;Immune System Diseases;innovation;Institution;instrument;instrumentation;Investigation;Lead;Life;Liver diseases;Microscope;Neurodegenerative Disorders;novel therapeutic intervention;Office Management;optical imaging;Research;Research Personnel;Research Project Grants;Services;Uncertainty;United States National Institutes of Health

PROJECT_TITLE: Zeiss LSM 980 confocal with Airyscan 2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (30)]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: ARLINGTON

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: Project Narrative Our studies of the elimination of morphologically complex cells will provide important fundamental insights on programmed cell death and clearance, which are essential facets of proper development and homeostasis. These studies are relevant to public health in several respects: our findings may help devise targeted therapies against both tumor formation and immune dysfunction as well as in understanding brain development, injury and disease.

PI_NAMEs: GHOSE, PIYA  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Animals;Apoptosis;Architecture;Autoimmune Diseases;Biological;Brain;Caenorhabditis elegans;cancer therapy;Cell Death;Cell Physiology;Cells;Cellular biology;Cessation of life;Complex;Defect;Development;developmental disease;Disease;Embryonic Development;Excision;experimental study;Genes;Genetic;genetic analysis;Genetic study;Health;Homeostasis;Immune System Diseases;in vivo;Inflammation;Injury;insight;Interphase Cell;Lead;Link;Malignant Neoplasms;Mitochondria;Modeling;Morphology;Mutation;Nerve Degeneration;Neurons;novel;programs;Public Health;Regulation;Regulator Genes;Resistance;Role;sex;targeted treatment;trafficking;tumor

PROJECT_TITLE: In Vivo Genetic Analysis of Compartmentalized Cell Elimination


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE Heterochronic or age disparate organ transplantation is a standard clinical practice with the potential of transferring rejuvenation (when transplanting young organs) or accelerated aging (when transplanting old organs), as well as with the potential for age reduction of donor organs in younger recipients. We have accumulated data on changes in biological age and compromised physical and cognitive capacities in experimental models supporting the concepts of organ rejuvenation and accelerated aging. A unique set of tools in transplantation models of translational relevance will delineate mechanisms of inter-organ communication.

PI_NAMEs: GLADYSHEV, VADIM N. (contact);TULLIUS, STEFAN GUNTHER

PROJECT_TERMS: Acceleration;Acute;Affect;Age;age acceleration;Age disparity;age effect;age group;age related;age related changes;Aging;aging biomarker;aging mechanism;Animals;Attention;biological age;Biological Aging;Biological Assay;Biological Markers;Biological Models;Biological Phenomena;Biology of Aging;Biopsy;Body System;Cell Aging;Cell Compartmentation;Cells;Chronology;Clinical;clinical database;clinical practice;Clinical Research;clinically relevant;cognitive capacity;cognitive function;Communication;Complex;Data;Databases;Disparate;Distal;Environment;Experimental Models;experimental study;follow-up;Generations;Heart;Heart Transplantation;Human;human old age (65+);Immune response;immunogenicity;immunosenescence;innovation;Institution;Life;life span;Mediating;Mitochondrial DNA;Modeling;mouse model;Mus;Nature;novel;older patient;Organ;Organ Donor;Organ Transplantation;Pathway interactions;Patients;Peripheral;Physical Capacity;Physical Function;Physiological;Positioning Attribute;preclinical study;Prevention;pro-aging;Procedures;Process;Protocols documentation;Publishing;Rejuvenation;Research;Research Personnel;response;Role;Sampling;Science;Scientist;senescent cell;T cell response;Testing;Time;Tissues;tool;transcriptomics;translational model;transplant model;Transplant Recipients;Transplantation;transplantation medicine;Work

PROJECT_TITLE: Understanding Interorgan Communication Through Heterochronic Organ Transplantation


ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative  One early marker for cardiovascular disease is the process called “arterial stiffness”. However, the mechanisms of Western diet (high in fat and refined carbohydrates) and activation of the renin angiotensin– aldosterone system on arterial stiffness are poorly understood. Understanding the biochemical pathways leading to arterial stiffness should lead to specific interventional strategies, including new drugs and dietary interventions to prevent cardiovascular events in obese individuals.

PI_NAMEs: HILL, MICHAEL A;JIA, GUANGHONG  (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: Address;Aldosterone;arterial stiffness;Binding;Biochemical Pathway;Blood Vessels;Carbohydrates;Cardiovascular Diseases;Cardiovascular system;Cell membrane;Cell Physiology;Cells;Clinical;clinical diagnosis;Data;Deubiquitinating Enzyme;Diet;diet-induced obesity;Dietary Intervention;Early Diagnosis;Endosomes;Endothelial Cells;Endothelium;epidemiologic data;Epithelial Cells;epithelial Na+ channel;Event;exosome;Fatty acid glycerol esters;feeding;Functional disorder;Genetic Transcription;Genomics;human study;Hypertension;hypertensive;In Vitro;in vivo;Incidence;Inflammation;innovation;Intervention;Ion Channel;Mediating;Membrane;Mineralocorticoid Receptor;Modeling;mouse model;new therapeutic target;novel marker;novel therapeutics;obese person;Obesity;obesity prevention;Oxidative Stress;Patients;Phenotype;Plasma;Play;prevent;Process;programs;Proteins;Public Health;Receptor Activation;Receptor Cell;renal epithelium;Renin-Angiotensin-Aldosterone System;Research;Role;Signal Induction;Signal Transduction;Smooth Muscle Myocytes;STAT1 gene;Sucrose;trafficking;Translations;ubiquitin isopeptidase;Ubiquitin Specific Protease 8;Ubiquitination;United States;Vascular Diseases;Vascular Smooth Muscle;western diet

PROJECT_TITLE: Epithelial sodium channels in endothelial cells and arterial stiffening

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Malaria;Pediatric;Primary Immunodeficiencies;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Malaria is a disease that affects millions of people. The only medicines that work to cure certain forms of malaria cannot be used in about 1 in every 20 people because the medicines will make the people too sick to take the medicine. This research project explores why people get sick in response to these medicines and seeks strategies to fix the problem

PI_NAMEs: ZIMRING, JAMES C. (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Address;Affect;Anemia;Animals;Antioxidants;Automobile Driving;Biochemical;Biology;cell injury;cofactor;Color;Communities;Complex;conditional knockout;Data;design;Diet;dihydronicotinamide;Disease;drug metabolism;electron donor;Electron Transport;Electrons;Enzymes;Erythrocytes;Erythroid;Exons;Experimental Designs;experimental study;G6PD gene;Generations;Geography;Glucose;Glucosephosphate Dehydrogenase Deficiency;Grant;Hemolysis;Hemolysis Induction;Hemolytic Anemia;Human;humanized mouse;Impairment;In Vitro;in vivo;Individual;Infection;inhibitor;Intervention;Joints;Knock-out;Life;Liver;liver metabolism;LoxP-flanked allele;Malaria;Medicine;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;NADH;NADP;Niacinamide;novel;NQO1 gene;NRH - quinone oxidoreductase2;Nutritional status;Organ;oxidation;Oxidation-Reduction;Oxidoreductase;Oxygen;Pathway interactions;Patients;Pentosephosphate Pathway;Persons;Phagocytosis;Pharmaceutical Preparations;Phase;Plasmodium vivax;Population;prevent;Primaquine;Quinones;Reaction;Reactive Oxygen Species;Research Project Grants;response;riboside;Role;Source;Spleen;Superoxides;System;Testing;tool;Toxic effect;Transgenic Mice;translational approach;Translations;Variant;Work

PROJECT_TITLE: Nqo2 in Primaquine-Induced Hemolysis of G6PD-deficient RBCs

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Nearly all patients with BRCA-mutated or Homologous Recombination Deficient ovarian cancer respond to frontline chemotherapy with PARP inhibitor maintenance; however, disease recurrence and therapy resistance almost inevitably develop. Targeting Wnt signaling and RNA splicing are therapeutic strategies that could overcome therapy resistance and provide further therapeutic options to advance the care options for our patients. The proposed clinical trial and basic science research will evaluate a novel combination strategy for platinum resistant ovarian cancer patients and elucidate the suspected mechanism(s) of action.

PI_NAMEs: CORR, BRADLEY  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Adjuvant;advanced disease;Aftercare;Alternative Splicing;antitumor effect;Apoptosis;Basic Science;bevacizumab;Biopsy;brca gene;BRCA mutations;cancer cell;Cancer cell line;Cancer Model;Cancer Patient;Caring;cell type;Cells;chemotherapy;Chromatin Loop;clinical efficacy;Clinical Trials;Combined Modality Therapy;Comet Assay;Data;design;Disease;DNA;DNA analysis;DNA Damage;DNA Polymerase II;DNA Repair;DNA Repair Disorder;DNA-Directed RNA Polymerase;Dose;Dot Immunoblotting;Drug Kinetics;Evaluation;Event;extracellular;Future;Genes;Genetic;Genetic Transcription;Germ Lines;Goals;Gynecologic;Hematologic Neoplasms;homologous recombination deficiency;Hybrids;Immunohistochemistry;improved;In Vitro;in vivo Model;inhibitor;inhibitor therapy;innovation;Maintenance;Maintenance Therapy;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of ovary;Mediating;Modeling;mutant;Mutate;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;objective response rate;Operative Surgical Procedures;Oral;PARP inhibition;Pathway interactions;patient population;Patient Selection;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Phase I Clinical Trials;Phosphotransferases;Physiological;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Predisposition;primary endpoint;Production;Prognosis;Progression-Free Survivals;Property;Protein Isoforms;Protein Tyrosine Kinase;Proteins;Recommendation;Recurrence;Recurrent disease;Research;Resistance;Resistance development;resistance mechanism;response;RNA;RNA Splicing;Safety;secondary endpoint;Serous;Somatic Mutation;Specificity;standard care;standard of care;Stimulus;synergism;targeted treatment;Therapeutic;Therapeutic Agents;therapy resistant;transcriptomics;treatment response;trial design;tumor;Tumor Debulking;tumorigenesis;Tyrosine Kinase Inhibitor;Vegf Inhibitor;WNT Signaling Pathway;Work

PROJECT_TITLE: Evaluation of combination CLK/DYRK (Cirtuvivint) inhibition with PARP inhibition (Olaparib) in BRCA/HRD platinum resistant ovarian cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE In some individuals, B cells produce autoantibodies and promote chronic autoimmune disorders with no cure. High affinity self-reactive B cells develop and stay in the bone marrow tissue, but can enter the circulation in autoimmune patients. Our studies aim to establish the role of a chemoattractant cell receptor and of cell adhesion receptors in the bone marrow retention and release of these self-reactive B cells.

PI_NAMEs: PELANDA, ROBERTA  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Acute;adhesion receptor;Affect;Affinity;antagonist;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;autoreactive B cell;autoreactivity;Avidity;B cell repertoire;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Biochemical Pathway;Blood;Blood Cells;Bone Marrow;Cell Adhesion;Cells;central tolerance;chemokine receptor;Chemotactic Factors;Chronic;Circulation;CXCR4 gene;CXCR4 Receptors;Data;Defect;defined contribution;Development;drug development;experimental study;Gatekeeping;Gene Expression Profile;Genetic;Goals;Grant;Human;Immune Tolerance;in vivo;Individual;Injections;Integrin alpha4beta1;Integrins;Investigation;Licensing;Life;Mediating;Molecular;Mus;Pathologic;Pathway interactions;Patient Recruitments;Patients;Peripheral;peripheral tolerance;Physiologic pulse;Physiological;PIK3CG gene;Play;Population;Process;receptor;Receptor Cell;Research;Risk;Role;Sampling;Shapes;Signal Transduction;Spleen;Stromal Cell-Derived Factor 1;Testing;therapy development;Tissues

PROJECT_TITLE: Contribution and interplay of CXCR4 and integrins in central B cell tolerance

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Cognitive dysfunction, psychiatric symptoms, functional impairment, and disability following COVID-19 negatively impact Veterans’ community functioning and quality of life, contribute to significant human suffering, and are costly to VHA. Rehabilitation is a critical priority for Veterans with long COVID. One promising treatment to improve functioning in Veterans with post-COVID-19 cognitive symptoms is Compensatory Cognitive Training (CCT). Previous studies have found that CCT is feasible, acceptable, and efficacious in Veteran populations with multiple sources of cognitive dysfunction. This randomized controlled trial aims to address important RR&D priorities by examining feasibility, acceptability, and preliminary efficacy of a COVID- 19-specific rehabilitation intervention, CCT for long COVID (CCT-C) compared to a robust control condition. The proposed study has the potential to improve cognitive function, functional independence, and quality of life for Veterans with late or delayed effects of secondary conditions related to COVID-19 infections.

PI_NAMEs: AUSTIN, TARA  (contact)

PROJECT_TERMS: Acceleration;active control;Activities of Daily Living;Acute;acute COVID-19;Address;Adverse effects;Age;Anxiety;Area;Attention;Biological Markers;blood-brain barrier crossing;Brain;brain fog;Cardiovascular system;career;cerebrovascular;Chemicals;Chronic Headaches;chronic pain;Chronic Phase;Classification;Clinical;Clinical Trials;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive performance;cognitive rehabilitation;cognitive training;Communicable Diseases;Communities;Community Integration;Contracts;cost;COVID-19;COVID-19 severity;design;Development;Diagnosis;Diagnostic;disability;Disability Evaluation;Disabling;Disease;Education;emotional functioning;Employment;executive function;experience;Exposure to;Fatigue;Feedback;Functional impairment;functional improvement;functional independence;functional outcomes;hazard;Health behavior;health care service utilization;Health Status;Healthcare Systems;Household;Human;Hypoxia;Immune response;Impaired cognition;Impairment;improved;Infection;Inflammatory;Injury;Intervention;Interview;K-Series Research Career Programs;Length;Long COVID;longitudinal analysis;Measures;Mediating;Memory;Mental Depression;Mentors;Mentorship;Methodology;mild traumatic brain injury;military veteran;Moods;Neurobehavioral Manifestations;neuroinflammation;Neurons;Neurophysiology - biologic function;neuropsychiatric symptom;Neuropsychology;novel;Outcome;pandemic disease;Participant;Patient Self-Report;performance based measurement;Persons;Population;post intervention;post SARS-CoV-2 infection;post-COVID-19;Post-Traumatic Stress Disorders;Postdoctoral Fellow;Protocols documentation;psychiatric symptom;psychological distress;Psychometrics;psychosocial stressors;Quality of life;Randomized, Controlled Trials;Recording of previous events;recruit;rehabilitation research;Rehabilitation therapy;remote administration;Reporting;Research;Respiratory Signs and Symptoms;Risk;Sampling;SARS-CoV-2 infection;SARS-CoV-2 negative;Schedule;Scientist;secondary outcome;Secondary to;Sleep disturbances;social;Social Functioning;Source;statistics;Structure;Symptoms;Techniques;telomere;theories;Thinking;Time;Training;Trauma;treatment response;Veterans;Viral;Work;World Health Organization;World Health Organization Disability Assessment Schedule

PROJECT_TITLE: Cognitive rehabilitation to improve functioning in Veterans following COVID-19

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Lisa Cameron Title: Leica Stellaris confocal for a campus-wide shared resource Project Narrative To understand the molecular basis of the structure and function of our cells and tissues and how that can go wrong with disease, we need to be able to study samples in three dimensions. The requested confocal microscope will allow Duke researchers look deep into tissues to shed light on normal and abnormal processes important to priorities of NIH research initiatives to improve clinical outcomes.

PI_NAMEs: CAMERON, LISA A. (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: 16 year old;Basic Science;Behavior;Biomedical Engineering;Biomedical Research;Cancer Biology;Cardiac Myocytes;Cellular biology;Charge;Communities;Contract Services;Core Facility;Detection;detector;Development;Endocytosis;Equipment;experience;Fluorescence;fluorophore;Grant;Health;Human;Immunology;implementation facilitation;improved;Infection;Infrastructure;instrumentation;Lasers;Light;light microscopy;Manufacturer;Marketing;Methods;Microbiology;Microscope;Modeling;Molecular Genetics;Neurobiology;new technology;operation;pathogen;Pharmacology;Recording of previous events;Research;Research Personnel;Research Project Grants;Resource Sharing;Scanning;System;tau Proteins;Technology;Training;Translational Research;Universities

PROJECT_TITLE: Leica Stellaris Confocal for a Campus-wide Shared Resource


ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE The Brown University Proteomics Core Facility aims to enhance its capabilities and improve research outcomes by acquiring state-of-the-art equipment, including an Eclipse Tribrid Mass spectrometer, Vanquish Neo UHPLC system, and FAIMS Pro Duo interface. This investment will allow researchers in Rhode Island to perform high- throughput proteomics experiments with increased sensitivity, specificity, and accuracy, which will ultimately facilitate discovery and innovation in a state designated by the NIH as an IDeA state identified as needing increased research infrastructure support.

PI_NAMEs: SALOMON, ARTHUR ROBERT (contact)

PROJECT_TERMS: Aging;Area;Biological Markers;Biology of Aging;Brain;Cancer Biology;Cancer Center;Communicable Diseases;Communities;Core Facility;Detection;Disease;equipment acquisition;experimental study;Grant;Health;High Pressure Liquid Chromatography;Human;Immune system;Immunology;improved;Institution;instrument;instrumentation;Ions;mass spectrometer;Mass Spectrum Analysis;Minor;Mission;Modification;nanolitre;Neurodegenerative Disorders;novel therapeutics;Parasites;pathogen;Peptides;Post-Translational Protein Processing;Preparation;Protein Analysis;protein protein interaction;Proteins;Proteomics;Research;Research Infrastructure;Research Support;Resolution;Rhode Island;Sampling;Science;Speed;System;undergraduate student;United States National Institutes of Health;Universities;vaccine development

PROJECT_TITLE: Acquisition of an Eclipse Tribrid Mass Spectometer System to Advance Proteomics Research in Rhode Island


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Center for Quantitative Biology: A focus on "omics", from organisms to single cells PROJECT NARRATIVE Phase 2 established a Center for Quantitative Biology (CQB) that nucleated and grew the fusion of wet-bench “- omics” research with bioinformatics at Dartmouth. The center nurtured and mentored new projects that sought to understand changes in cells and tissue biopsies, including the detail of single-cell dynamics, using high- throughput methods and integration of diverse ‘-omic’ data that are now being applied widely to multiple systems, diseases, cell types, and organisms to improve our understanding of healthy tissues and disease processes. Phase 2 will continue to build and grow the COBRE Center for Quantitative Biology that provides unique resources to investigators at Dartmouth and our IDeA partners, enhancing research productivity and funding competitiveness across the region.

PI_NAMEs: WHITFIELD, MICHAEL L (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Administrative Efficiency;Adoption;Advisory Committees;Area;Arts;Bioinformatics;Biological Process;biological research;Biological Sciences;Biology;biomedical data science;Biopsy;Cell Physiology;cell type;Cells;Centers of Research Excellence;Collaborations;Communities;computer science;Computing Methodologies;computing resources;Data;Data Analytics;data integration;Data Science;Data Science Core;Discipline;Disease;Dryness;Education;Engineering;Environment;Epidemiology;experience;experimental study;Extramural Activities;Faculty;Faculty Recruitment;faculty support;Fostering;frontier;Funding;Generations;genomic data;Genomics;Goals;Growth;Health;Home;human disease;Immune;Immunology;improved;Infrastructure;Institution;International;Investments;Leadership;Lung;Mathematics;medical schools;member;Mentors;Methods;Microbiology;Modeling;Molecular;Molecular Biology;Molecular Epidemiology;multidisciplinary;Names;new technology;next generation;Organism;Phase;Pilot Projects;Population;Positioning Attribute;Process;Productivity;programs;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Schools;Science;Scientific Inquiry;Scientist;senior faculty;Services;single cell genomics;Structure;success;synergism;System;Systems Biology;Talents;Technology;tenure track;Tissues;transcriptomics;Translating;Translational Research;United States National Institutes of Health;Vision;Whole Organism;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (C2)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science

PROJECT_TERMS: Address;Advisory Committees;Animals;Area;Arts;base;Bioinformatics;Biological Process;Biological Sciences;Biology;Biometry;Budgets;cell type;Cells;Centers of Research Excellence;college;Communication;Communication Tools;Communities;Complex;Consultations;Data;data exchange;data integration;data repository;Data Science;Data Science Core;design;Development;Disease;Engineering;Ensure;Evaluation;Faculty;Faculty Recruitment;Fostering;Funding;Funding Opportunities;Generations;genomic data;Genomics;Goals;Grant;Health;Home;human subject;Immune;innovation;insight;Internet;Leadership;medical schools;meetings;Mentors;Mentorship;metabolomics;Methods;Molecular;Occupational activity of managing finances;operation;Organism;Persons;Phase;Pilot Projects;Population;Preparation;programs;Proteomics;Protocols documentation;recruit;Regulation;Research;research and development;Research Personnel;Research Project Grants;Resources;Schedule;Schools;Science;Scientist;Secure;single cell genomics;social media;success;System;Technology;Training;transcriptomics;United States National Institutes of Health;Visit;Whole Organism;Work

PROJECT_TITLE: Center for Quantitative Biology Administrative Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PI_NAMEs: KOLLING IV, FRED W (contact)

PROJECT_TERMS: Applications Grants;Archives;Area;Autoimmune Diseases;Autoimmunity;Award;bacterial community;base;Biological;Biological Process;Biological Sciences;Biology;Cancer Biology;Cell Separation;Cells;Centers of Research Excellence;Clinical;Collaborations;Communities;complex biological systems;complex data;Consultations;Core Facility;Data;Data Science Core;Dedications;design;Development;digital;Discipline;Disease;Dissociation;Distant;DNA;DNA sequencing;endometriosis;Ensure;Event;Evolution;experience;Experimental Designs;experimental study;Faculty;Fees;Generations;genetic variant;genomic data;Genomics;Grant;Health;Heterogeneity;Histology;Hormones;Human;human data;Human Resources;Image;Immune;Immune response;Immune system;Immunofluorescence Immunologic;Immunologic Receptors;Immunology;Individual;Industry;Infection;Infrastructure;insight;Institution;instrumentation;Laboratories;Leadership;Learning;Libraries;Malignant Neoplasms;Management Information Systems;Manuscripts;Measurement;Measures;meetings;member;metabolomics;Metagenomics;method development;Methods;Mission;Modality;Molecular;monocyte;Multiomic Data;multiple omics;Nerve Degeneration;Organism;Organoids;Pathology;Patients;Phase;Phenotype;Population;Preparation;programs;Proteomics;protocol development;Protocols documentation;Publications;Publishing;Quality Control;Reagent;Research;Research Personnel;Resource Sharing;Resources;RNA;sample collection;Sampling;Science;Scientist;Secure;Services;single cell genomics;single cell technology;Site;Specimen;Standardization;System;Techniques;Technology;therapy resistant;Tissue imaging;tissue processing;Tissue Stains;Tissues;tool;transcriptomics;Translational Research;tumor progression;Update;Whole Organism;Work

PROJECT_TITLE: Single Cell Genomics Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Coronaviruses;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SOUCY, SHANNON  (contact)

PROJECT_TERMS: analysis pipeline;Area;base;Bioinformatics;Biological;Biological databases;Biological Process;Biology;Biomedical Research;Cells;Centers of Research Excellence;cluster computing;Collaborations;Communities;Complex;Computer Analysis;Computing Methodologies;computing resources;Core Facility;COVID-19 pandemic;Data;Data Analyses;data analysis pipeline;Data Analytics;Data Science;Data Science Core;Data Set;data standards;Development;education resources;Educational Materials;Educational workshop;experience;Experimental Designs;experimental study;Fees;forging;Future;Gene Expression;genome-wide analysis;genomic data;Genomics;Human Genome;Human Resources;implementation facilitation;Infrastructure;innovation;insight;instrumentation;Investments;Maintenance;Measures;Mentors;Methodology;Methods;Microscopic;Modality;multidimensional data;multidisciplinary;Names;new technology;next generation sequencing;novel;novel strategies;Organism;Participant;Phase;Play;Procedures;Research;Research Personnel;Research Project Grants;Resolution;Resources;Role;SARS-CoV-2 genome;Series;Services;single cell analysis;single cell genomics;Statistical Data Interpretation;statistics;Stream;Structure;Techniques;Technology;Training;transcriptomics

PROJECT_TITLE: Genomic Data Science Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Contraception/Reproduction;Genetics;Human Genome;Women's Health Research

PI_NAMEs: GOODS, BRITTANY ANNE (contact)

PROJECT_TERMS: Address;ATAC-seq;Behavior;Biology;career;cell behavior;Cell Physiology;cell type;Cells;Centers of Research Excellence;Complex;Coupled;Data;Data Science Core;Data Set;design;Disease;dosage;Endocrine system;Endometrial;endometriosis;Environment;Epithelial Cells;Epithelium;female reproductive tract;Fertilization;Generations;Genetic Transcription;genomic data;Goals;Gonadal Steroid Hormones;Health;Heterogeneity;Hormonal;Hormones;Immune;Immune system;Infection;Inflammatory;Inflammatory Response;Knowledge;Leadership;Ligands;Macrophage;Macrophage Activation;Maintenance;Maps;Menstrual cycle;Menstruation;Mentors;Methods;Molecular;multiple omics;Organism;Pain;pathogen;Pathology;Patients;Periodicity;Phenotype;Population;Pregnancy;programs;receptor;Regulatory Element;reproductive;Research;Research Project Grants;Resistance;response;Role;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Stimulus;Stromal Cells;success;System;Systems Biology;targeted treatment;Therapeutic;Time;Tissues;transcriptome;transcriptomics;Uterine Diseases;Uterus;Work

PROJECT_TITLE: Goods - Proj 1