ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE An evolutionary expansion of the cortex, in particular corticospinal neurons, has long been hypothesized to underlie the exceptional dexterity of primates, but it is unclear how this expansion affects neural circuits and whether there is a causal link between corticospinal neuron number and dexterous behavior. Deer mice (Peromyscus maniculatus) are a uniquely advantageous system in which to address this problem as an experimentally tractable system with innate natural variation in motor skill that correlates with variation in corticospinal neuron number. This proposal thus aims to use deer mice to test the hypothesis that the expansion of specific corticospinal neuron populations results in changes in neural activity and dexterous behavior, thus fulfilling the seventh goal of the BRAIN Initiative by integrating across levels of understanding to contextualize cell types in circuit function, and circuit function in behavioral output.

PI_NAMEs: TYSSOWSKI, KELSEY MARIE (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Address;Advisory Committees;Affect;Amyotrophic Lateral Sclerosis;Animals;Architecture;Area;autism spectrum disorder;Behavior;behavior prediction;Behavioral;Biological Models;Biology;BRAIN initiative;candidate identification;career;cell type;Cells;Cerebral cortex;Cervical spinal cord structure;Cognitive;cognitive capacity;cognitive enhancement;Communication;comparative;Computer Analysis;Corticospinal Tracts;Coupled;Data;Data Set;Deer Mouse;Development;dexterity;Disease;Distant;Evolution;experimental study;Forelimb;forest;Foundations;Genes;Genetic;genetic manipulation;Goals;Habitats;Hand;high dimensionality;Histology;Human;Impairment;improved;Individual;Lesion;Link;Measures;Mediating;Mentors;Mentorship;Modeling;Molecular;molecular marker;Motor;Motor Cortex;Motor Skills;Movement;Mus;Nervous System Disorder;neural;neural circuit;neural correlate;Neuroanatomy;neuron development;neuronal circuitry;Neurons;Neurosciences;North Carolina;Output;Pattern;Peromyscus;Phase;Physiological;Population;Population Sizes;Positioning Attribute;Primates;programs;Research;Rodent;Role;single cell sequencing;single nucleus RNA-sequencing;skills;Spinal Cord;Structure;System;Technology;Testing;Time;tool;Training;Universities;Variant;Viral;Work

PROJECT_TITLE: A comparative approach to uncovering the cellular and circuit basis of the role of the corticospinal tract in motor skill

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (02)]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Malaria parasites must cycle between their mosquito and mammalian hosts yet the role of parasite burden in the mosquito to ongoing transmission has not been investigated. We have recently found that highly infected mosquitoes are 7.5 times more likely to initiate malaria infection. The proposed study will investigate the mechanisms underlying the increased infectiousness of highly infected mosquitoes, the results of which will inform epidemiologic models and design of transmission-blocking strategies.

PI_NAMEs: SINNIS, PHOTINI  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Age;Anopheles Genus;Area;Belief;Biological;Biological Assay;Biology;Bite;Blood;Blood Vessels;Cessation of life;Clinical;Compensation;Complement;Complex;Culicidae;Data;Data Correlations;density;design;epidemiological model;Epidemiology;experimental study;Gene Expression Profile;Genome;Gland;Human;improved;in vivo;Infection;Intervention;intravital imaging;Investigation;Knowledge;Life Cycle Stages;Liver;liver infection;Malaria;malaria infection;Modeling;Morbidity - disease rate;mortality;Motility;Mus;Outcome;Parasites;Phenotype;Plasmodium;Plasmodium falciparum;Probability;Research Personnel;Rodent;Rodent Model;Role;Salivary Glands;secondary infection;single-cell RNA sequencing;Skin;Sporozoites;Testing;Time;transmission blocking;transmission process;Variant;vector

PROJECT_TITLE: Investigating the Mechanisms Underlying Mosquito Infectiousness in Malaria

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research

ORG_CITY: STONY BROOK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Project Narrative There is a higher incidence and mortality of colorectal cancer (CRC) in individuals self-identifying as Black race compared to all other races and ethnicities in the US. We propose to demonstrate the feasibility of conducting spatial profiling of self-identified Black vs. White CRC differentially expressed genes in self-identified Black vs. White CRC FFPE tissues archived at three major medical centers, by a multi-disciplinary research team with combined expertise in clinical gastroenterology and pathology, ISH/IHC, and bioinformatics.

PI_NAMEs: GUILLAUME, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Admixture;African ancestry;Age;Archives;Bioinformatics;Biological;Black race;Cancer Biology;Categories;Cd68;cell type;Cells;Clinical;clinical care;Collection;Colorectal Cancer;Complex;Computer software;Confounding Factors (Epidemiology);County Hospitals;CXCL10 gene;Data;data portal;Data Set;Diabetes Mellitus;differential expression;digital imaging;digital pathology;Ethnic Origin;European ancestry;Formalin;Freezing;Gastroenterology;Gene Expression;Gene Expression Profile;Genes;Genomics;Germ Lines;Goals;Health Insurance;Hospitals;Immunohistochemistry;Immunologics;In Situ Hybridization;Incidence;Individual;Infiltration;Insurance Coverage;Interdisciplinary Study;Interferon Type II;Link;Macrophage;Manufacturer;Measures;Medical center;Metadata;Mismatch Repair;mortality;Myelogenous;Myeloid Cells;Nucleic Acids;Obesity;open source;Outcome;Paraffin Embedding;Pathology;Postoperative Period;Prevalence;Process;Proteins;Protocols documentation;PTPRC gene;Race;racial difference;racial disparity;RNA Sequences;sample archive;sample fixation;Sample Size;Sampling;sex;Signal Transduction;Smoking;SNP array;Source;Stains;T cell infiltration;T-Lymphocyte;Testing;The Cancer Genome Atlas;tissue archive;Tissue Embedding;Tissue Sample;Tissues;Transcript;transcriptome sequencing;tumor;tumor-immune system interactions;University Hospitals

PROJECT_TITLE: Disentangling the effect of Black/African Ancestry from confounding variables on colorectal cancer biology

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: PROJECT NARRATIVE Fundamental advances in our understanding of the normal function of the human brain, and how this understanding can be used to combat brain disorders, will increasingly depend on researchers equipped with multidisciplinary technical expertise. This grant supports an advanced hands-on three-week summer course which provides a forum for in-depth evaluation of the emerging and converging research efforts linking ion channel biology, synaptic and circuit function to human brain physiology and disease. The course communicates fundamental concepts and cutting-edge experimental approaches to a select cadre of graduate and postgraduate trainees, who will immediately apply what they learn to their own areas of neurobiological research. This highly intensive course helps to embed the trainees in a motivated and collaborative network of like-minded scientists who are working to understand the fundamental operating principles of the central nervous system and the etiology of neurological disorders.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Action Potentials;Acute;Address;Area;Astrocytes;Attention;Biochemistry;Biology;Biophysics;Brain;Brain Diseases;Cell Communication;Cells;Central Nervous System;Closure by clamp;Collaborations;combat;Communication;Communities;Complex;Course Content;course introduction;Creativeness;Cultured Cells;data acquisition;Data Analyses;design;Disease;Dissection;Dissociation;Educational process of instructing;Electrophysiology (science);Enrollment;Ensure;Environment;Equilibrium;Etiology;Evaluation;Exercise;experience;experimental study;extracellular;Faculty;fascinate;forging;Fostering;Future;Gender;Goals;graduate student;Grant;Human;Image;In Vitro;in vivo;insight;instructor;interest;International;Ion Channel;Ion Channel Gating;Knowledge;Laboratories;laboratory manuals;Lead;Learning;lecturer;lectures;Ligands;Link;Mental Health;Methodology;Methods;Mind;Molecular Biology;multidisciplinary;Mus;Nervous System;Nervous System Disorder;neural;neural circuit;neural network;Neurobiology;Neuroglia;neuronal excitability;Neurons;Neurosciences Research;new technology;novel strategies;online resource;optogenetics;Participant;patch clamp;Pathology;Peripheral;Pharmacogenetics;pharmacologic;Pharmacology;Physiological;Physiology;Postdoctoral Fellow;Process;programs;Property;Publications;Reporting;Research;Research Personnel;Research Project Grants;Research Training;response;Role;Scientist;sensory stimulus;Slice;Students;Synapses;Synaptic Transmission;System;Technical Expertise;Techniques;Technology;Thinking;Time;tool;Training;Training Programs;Underrepresented Minority;Update;voltage;Work

PROJECT_TITLE: Ion Channels in Synaptic and Neural Circuit Physiology Course (2024-2028)

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-L (99)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: KNOXVILLE

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: Project Narrative Public Health Relevance Statement: The proposed research is relevant to public health because Planning Together intervention is an accessible contraceptive education program for economically marginalized families to improve consistent desired contraceptive use postpartum. Planning Together protocol targets multiple levels of factors impacting contraceptive use, including (a) reducing social barriers (i.e., harnessing existing social support by including the sexual partner and optimizing couple contraceptive communication using evidence- based techniques), (b) reducing structural barriers associated with structural drivers of health (SDOH) that can negatively impact consistent desired contraceptive use, via (c) providing a flexible delivery method (ie., synchronous and asynchronous components; online and in-person intervention access) to increase access and scalability. This innovative couple-based, multi-level intervention has the potential to redesign existing family planning education modes to improve consistently desired couple contraceptive usage, with the longer- term goal of reducing short interpregnancy intervals (SIIs).

PI_NAMEs: ROBERSON, PATRICIA N. E. (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Agreement;arm;Clinical Trials;Communication;Communities;community engaged research;Consultations;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Couples;Data;Decision Making;design;economic need;Education;Educational Intervention;Educational process of instructing;Effectiveness;evidence base;Face;Family;Family health status;Family Planning Education;flexibility;follow-up;Funding;Future;Goals;Health;health care availability;health economics;Health Personnel;Health Professional;high risk;improved;Individual;infant morbidity/mortality;Infant Mortality;innovation;Interactive Communication;Intervention;Interview;Joints;Knowledge;male;Manuals;marginalization;marginalized population;maternal morbidity;Mental Health;Methods;Nature;novel;Occupations;Oral;Outcome;Participant;patient oriented;Patients;Pattern;person centered;Persons;physical conditioning;pilot test;pilot trial;postnatal;Postpartum Depression;postpartum outcome;Postpartum Period;pregnant;Premature Birth;prenatal;Prenatal care;prevent;Problem Solving;Process;programs;Protocols documentation;psychological distress;Public Health;public health relevance;Reporting;Research;Resources;reversible contraceptive;Risk;satisfaction;Sexual Partners;skills;social;Social support;Structure;systemic barrier;Techniques;Testing;Time;Training;United States National Institutes of Health;uptake;Vocational Education

PROJECT_TITLE: Couple-based prenatal contraceptive education program for economically marginalized families

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Unintentional Childhood Injury

ORG_CITY: IOWA CITY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Drowning is a leading cause of unintentional death among 1-to-14 year olds in the U.S. and a source of permanent brain damage and other long-term impairments among individuals across all ages. Many drownings occur despite the presence of lifeguards, which rather than reflecting poor lifesaving skills or negligence is likely caused by fundamental limitations of human perception and attention. The goal of this project is to develop a set of tools through which the complex environment and task of lifeguard surveillance can be studied under controllable conditions in order to identify specific sources of surveillance failure which can then be used to guide the development of targeted training and operational procedures aimed at reducing the number of preventable drownings that occur each year.

PI_NAMEs: MOORE, CATHLEEN M (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: 14 year old;4 year old;Accidents;Address;Age;age group;animation;Attention;barrier to testing;Basic Science;Belief;Brain Injuries;Cessation of life;Child;Cognition;Color;Complex;Country;Detection;Development;Drowning;Educational process of instructing;Elements;Emergency Situation;Environment;Equilibrium;Ethics;Event;experimental study;Face;Failure;Feedback;Goals;Grant;Head Movements;High Prevalence;Human;Impairment;Individual;information processing;interest;Laboratories;Life;Link;Literature;Low Prevalence;Measures;Mental Fatigue;Modeling;Monitor;Movement;Negligence;Participant;Perception;Performance;Phase;Prevalence;Prevention;Procedures;Property;Publishing;Research;Research Proposals;Resources;response;Running;skills;Source;Structure;success;Swimming Pools;Testing;tool;Training;Trauma;United States National Institutes of Health;virtual reality;virtual reality environment;Visual attention;visual cognition;Visual Perception;visual search;Water;Work

PROJECT_TITLE: A virtual reality lifeguarding environment for research and training

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Nanotechnology;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Pancreatic cancer (PC) is one of the most lethal forms of cancer in the United States (5-year survival rate below 10%) and is often treated with adjuvant chemotherapeutics (e.g., gemcitabine, 5-FU and oxaliplatin) known for their high off-target delivery and systemic toxicity. There is an urgent need to develop new therapeutic strategies consisting of delivery vehicles able to actively target PC cells, limit chemotherapy off-target toxicity and improve the overall anticancer response. To address this unmet medical need, we will leverage our experience in cancer-specific antigen discovery and validation, bio-nanomaterial engineering, and exosome biology to test the novel hypothesis that EMs engineered with a nanobody against ICAM1, an overexpressed PC surface protein, and loaded with gemcitabine, 5-FU and oxaliplatin can be used as a novel biological nanomedicine for precision PC therapy.

PI_NAMEs: MOSES, MARSHA A (contact)

PROGRAM_OFFICER_NAME: SORG, BRIAN S

PROJECT_TERMS: Ablation;Address;Adjuvant;Adjuvant Chemotherapy;Adjuvant Therapy;Adverse effects;Algorithms;Animal Cancer Model;anti-cancer;Antigens;Antineoplastic Agents;aqueous;Area;Biodistribution;Biological;Biology;cancer diagnosis;Cancer Etiology;cancer therapy;cancer type;Cell Communication;Cell secretion;Cell surface;Cells;Cessation of life;chemotherapy;Clinical;clinical translation;delivery vehicle;density;Development;Diagnosis;Disease;Drug Delivery Systems;Drug Kinetics;effective therapy;efficacy evaluation;Electroporation;Endosomes;engineered exosomes;Engineering;Environment;Epidermal Growth Factor Receptor;Excision;Exhibits;exosome;experience;extracellular vesicles;Failure;Fluorouracil;gemcitabine;Goals;Growth;Heterogeneity;Human;Human Resources;Hypotension;immunogenicity;Immunoglobulins;Immunotherapy;improved;in vivo;in vivo Model;innovation;instrument;Intercellular adhesion molecule 1;intercellular cell adhesion molecule;Legal patent;Life;Lipid Bilayers;Liposomes;Magnetism;Malignant neoplasm of pancreas;Malignant Neoplasms;manufacture;Measures;Medical;Membrane;Membrane Glycoproteins;Membrane Proteins;Methods;mimetics;Morphology;multidisciplinary;Myelosuppression;nanobodies;nanomedicine;nanoparticle;nanopolymer;nanosized;nanovesicle;Neoadjuvant Therapy;neoplastic cell;Normal tissue morphology;novel;novel therapeutic intervention;nucleoside analog;Operative Surgical Procedures;Organ;overexpression;oxaliplatin;pancreas development;pancreatic cancer cells;pancreatic cancer patients;particle;patient prognosis;Patients;Pharmaceutical Preparations;Phenotype;Platinum;precision drugs;Preparation;Prognosis;Protocols documentation;Publishing;Reproducibility;response;Scientist;screening;Structure;success;Surface Antigens;Survival Rate;systemic toxicity;targeted delivery;targeted treatment;Techniques;Testing;Therapeutic;therapeutically effective;Time;tool;Toxic effect;Training;Tropism;tumor;tumor specificity;Ultracentrifugation;United States;Validation;Vesicle

PROJECT_TITLE: Engineered exosome mimetics as targeted biological nanomedicines for pancreatic cancer

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Psoriasis

ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PUBLIC HEALTH RELEVANCE Sensory neurons and immune cells play key roles in skin inflammation and disease. In this application, we seek to develop recombinant botulinum proteases that can penetrate into skin cells to inhibit the release of neuropeptides in neurons and cytokines in immune cells. When successful, these studies will identify topical therapeutic candidates that could be used to regulate inflammation for the treatment of a myriad of skin diseases.

PI_NAMEs: DAI, XING ;JIN, RONGSHENG  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Address;Affect;afferent nerve;Afferent Neurons;Antibodies;Anxiety;Atopic Dermatitis;Biochemical;Biological Products;Botox;botulinum;Botulinum Toxins;Calcitonin Gene-Related Peptide;Cells;Chimeric Proteins;chronic inflammatory skin;Clinic;Communication;Complement;Cosmetics;Cultured Cells;cytokine;Cytosol;cytotoxicity;design;Disease;Engineering;Escherichia coli;experimental study;Goals;IL17 gene;Immune;immune cell infiltrate;immune function;Immune Targeting;Immunofluorescence Immunologic;Immunologics;improved;in vivo;Inflammation;Inflammatory;Inflammatory Response;Injections;innovation;interleukin-23;intradermal injection;Intramuscular Injections;Light;mast cell;Mediating;Medicine;member;Modeling;Molecular Weight;Motor Neurons;mouse model;Mus;Muscle;neoantigens;Neuroimmune;Neurons;Neuropeptides;neurotransmitter release;Pain;Paralysed;Pathology;Patient-Focused Outcomes;Patients;Penetration;Peptide Hydrolases;Peptides;Play;preclinical study;prevent;Proliferating;Proteins;Pruritus;Psoriasis;public health relevance;receptor;Recombinant Fusion Proteins;Recombinants;Reporting;Research;Site;Skin;skin barrier;skin damage;skin disorder;Skin Tissue;SNAP receptor;SNAP23 gene;spasticity;Stress;Substance P;substance use;Surface;Synaptic Vesicles;targeted agent;Testing;Therapeutic;therapeutic candidate;therapeutic target;Topical application;Toxic effect;Toxin;Variant;Vascular Permeabilities;Vesicle;Work

PROJECT_TITLE: Cell-penetrating botulinum proteases as topical therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-H (02)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: SAN MARCOS

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA STATE UNIVERSITY SAN MARCOS

PHR: Project Narrative. The mission of this SEPA grant at California State University San Marcos (CSUSM) is to foster thoughtful American Indian scholars of science by engaging motivated American Indian youth and their families in a culturally validated, comprehensive and layered science education, mentoring, and research program that will build the skills and confidence necessary for students to matriculate into and succeed in the biomedical and behavioral sciences. Youth will be provided mentoring from both program faculty and from near-peer mentors, will engage in interactive science activities, and will have the opportunity to both shadow in research labs and develop their own research projects to address substance use and opioid overdose in their communities.

PI_NAMEs: ARMENTA, RICHARD FRANK (contact)

PROGRAM_OFFICER_NAME: HOLMES, ANGELA L

PROJECT_TERMS: addiction;Address;American Indian community;American Indian Population;American Indians;Area;Behavioral;Behavioral Research;Behavioral Sciences;Biomedical Research;California;career;Clinical Research;College Preparation;Communities;community college;community engagement;community partnership;Disparity;Education;Educational Activities;Educational Curriculum;Educational workshop;Enrollment;Epidemiology;Exclusion;experience;Faculty;Family;Fostering;Future;Goals;Graduation Rates;Grant;health disparity;high school;High School Student;higher education;Imagination;Indigenous;interest;junior high school;Knowledge;laboratory experience;Learning;life span;matriculation;Mentors;Mission;National Institute of Drug Abuse;National Institute of General Medical Sciences;non-Native;opioid overdose;Outcome Measure;overdose prevention;peer coaching;programs;Readiness;Recording of previous events;Reporting;Research;Research Activity;Research Project Grants;Running;satisfaction;Schools;Science;science education;Science, Technology, Engineering and Mathematics Education;Scientist;Self Efficacy;skills;social;STEM career;STEM curriculum;STEM field;STEM program;Students;Substance Addiction;substance use;substance use prevention;summer program;Training Programs;Training Support;tribal community;Trust;twelfth grade;United States National Institutes of Health;Universities;university student;Validation;Youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (55)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: EAST LANSING

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: This proposal examines the association between maternal lifetime exposure to structural racism, in the form of neighborhood disadvantage resulting from residential segregation, and the presence of inflammatory pathways in their infant’s neonatal dried blood spot collected at birth.

PI_NAMEs: JOSEPH, CHRISTINE LM (contact);WEGIENKA, GANESA REBECCA

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;Adult;Area;biological adaptation to stress;Biometry;Birth;Black Populations;Black race;Blood;cancer survival;Child;Chronic;Chronic Disease;cohort;Communities;cooking;County;Data;Data Collection;Development;Dimensions;Disadvantaged;Disease;Dryness;Economics;Education;Employment;Epidemiology;Exposure to;fetal programming;Fetus;food desert;Health;health care service organization;Health Disparities Research;health inequalities;Home;Housing;Illinois;Immune;Incidence;Inequity;Infant;Infant Mortality;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;intergenerational;Intervention Studies;Life;Life Cycle Stages;Life Expectancy;Link;Literature;Maternal Exposure;Measures;Mental Health;metabolomics;metropolitan;Michigan;Minority;minority communities;minority health;minority health disparity;Modeling;Mothers;neighborhood disadvantage;Neighborhoods;Neonatal;offspring;Outcome;Outcome Measure;Parents;Participant;Pathway interactions;patient population;Patient Self-Report;physical conditioning;physical separation;Police;Policies;Population Heterogeneity;Poverty;Process;Race;racial determinant;racial disparity;racial health disparity;Racial injustice;racism;Recording of previous events;recruit;Research Personnel;residence;Residential Mobility;residential segregation;Resources;response;Schools;segregation;Sequence Analysis;social;sociodemographics;Socioeconomic Status;Spottings;Stress;Structural Racism;Structure;suburb;System;Target Populations;Testing;Theoretical model;theories;Time;Toxic Environmental Substances;transmission process;Up-Regulation;urban planning;White Women;Women's cohort;Work;working class;Youth

PROJECT_TITLE: Examining maternal lifetime exposure to structural racism and metabolomics in neonatal dried blood

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Endocannabinoid System Research;Mental Health;Neurosciences;Social Determinants of Health;Substance Misuse

ORG_CITY: Auburn

ORG_DEPT: BIOLOGY

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: Project Narrative. This project is relevant to public health because it aims to identify a novel mechanism of Cannabis Use Disorder, a major public health concern in the era of increasing cannabis legalization. Stress- elicited cannabis use motivation is associated with worse Cannabis Use Disorder outcomes, but how stress impacts cannabis use motivation is not well-understood. This study seeks to identify a causal physiological mechanism driving stress increases in neural drug-cue reactivity in order to pave the way for rapid development and testing of targeted treatments.

PI_NAMEs: MACATEE, RICHARD  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Acute;acute stress;addiction;Animal Model;Arousal;Attention;Automobile Driving;biological adaptation to stress;Biological Markers;Blood specimen;Cannabis;cannabis cue;Chemosensitization;Chronic;Clinical Research;cost;craving;Crossover Design;cue reactivity;Cues;Data;design;Development;disability;Double-Blind Method;Electroencephalography;Endocannabinoids;endogenous cannabinoid system;Etiology;Evaluation;Experimental Designs;FDA approved;Glucocorticoids;Goals;Human;Hydrocortisone;hypothalamic-pituitary-adrenal axis;incentive salience;indexing;Individual;Intervention;Investigational Therapies;long term abstinence;marijuana legalization;marijuana use;marijuana use disorder;marijuana user;Measures;Mediating;Mediation;Methodology;Methods;model development;Motivation;National Institute of Drug Abuse;neural;neuroimaging;non-genomic;noradrenergic;novel;Outcome;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Placebo Control;Placebos;Plasma;pre-clinical;Prevalence;psychosocial;Psychosocial Stress;psychosocial stressors;Public Health;public health priorities;Publishing;Randomized;response;reward processing;Rewards;Role;Sampling;Severities;Signal Transduction;Stimulus;Stress;Stress and Coping;stress reactivity;stressor;System;Testing;Therapeutic Research;Time;United States;Work;Yohimbine

PROJECT_TITLE: Experimental evaluation of the mechanisms driving acute stress potentiation of drug cue reactivity in Cannabis Use Disorder

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE The biological determinants of Alzheimer’s disease and related dementias (ADRD) are established decades before clinical symptoms of cognitive decline, memory loss and functional decline are observed. As age is the most reliable predictor of ADRD, the proposed study will test whether biological age, as opposed to chronological age, predicts higher levels of preclinical AD biomarkers, as measured with a highly reliable plasma beta-amyloid (Aβ) marker, and whether Aβ accumulation contributes to cognitive decline in midlife in a well-established longitudinal twin sample, the Louisville Twin Study. The nature of this twin design will inform causal pathways between early life development, biological age, Aβ, and cognitive functioning at midlife, shedding light on genetic and environmental mechanisms that promote risk and resilience of preclinical AD.

PI_NAMEs: BEAM, CHRISTOPHER RYAN (contact);DAVIS, DEBORAH WINDERS

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: abeta accumulation;Address;Adult;Age;Alzheimer's disease related dementia;Amyloid beta-Protein;Archives;Arithmetic;Biological;biological age;Biological Aging;Biological Markers;Child;Child Development;Childhood;Chronology;Clinical;Cognition;cognitive ability;cognitive development;cognitive function;cognitive task;cognitive testing;Data Collection;design;Development;Environmental Risk Factor;Etiology;functional decline;Funding;Future;Genetic;Goals;Grant;Growth;Impaired cognition;Individual;innovation;Intelligence;Life;life span;Light;Link;Measures;Memory Loss;Methods;middle age;Modeling;Nature;Neurobehavioral Manifestations;Pathway interactions;Plasma;pre-clinical;Protocols documentation;resilience;response;Risk;Sampling;Specific qualifier value;Standardization;Symptoms;Testing;theories;trend;Twin Multiple Birth;Twin Studies;United States National Institutes of Health;Update;Vocabulary

PROJECT_TITLE: Contribution of child development, biological aging, and beta-amyloid to cognitive function of the Louisville twins at midlife


NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Lung;Pulmonary Fibrosis;Rare Diseases;Scleroderma

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Systemic sclerosis (SSc)-associated interstitial lung disease (SSc-ILD) is currently the most lethal complication of the disease. Unfortunately, currently available murine and in vitro models for SSc fall short of fully and accurately modeling the disease. We propose to test the role of these cytokines in healthy control (HC) and SSc-ILD explant cultures and that single cell analyses of these cultures will provide unprecedented insight into the cellular interactions and soluble mediators that lead to lung fibrosis.

PI_NAMEs: LAFYATIS, ROBERT A. (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Aging;alveolar epithelium;Autoantibodies;Autoantigens;Autoimmunity;autoinflammation;Automobile Driving;Back;Blood Vessels;Cell Aging;cell injury;cell type;Cells;Cessation of life;circulating biomarkers;Clinical;Coculture Techniques;Complex;Complication;cytokine;Disease;disease model;Environmental Risk Factor;Epithelial Cells;Etiology;Fibroblasts;Fibrosis;Gene Expression;Genes;genetic association;Genetic Markers;idiopathic pulmonary fibrosis;IL-6 inhibitor;Immune;immune activation;immunoregulation;In Vitro;in vitro Model;Inflammatory;inhibitor;insight;Interleukin-13;Interleukin-4;Interleukin-6;Interleukins;Interstitial Lung Diseases;Lung;Lung Diseases;Macrophage;Macrophage Colony-Stimulating Factor;Mediating;Mediator;Methodology;Modeling;Molecular;Mus;Myofibroblast;novel;novel therapeutics;Pathogenesis;Pathologic;Pathway interactions;Patients;Phenotype;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor B;Play;Population;Pre-Clinical Model;Process;Protocols documentation;Pulmonary Fibrosis;receptor;Reporting;Role;senescence;Series;Serum;Signal Transduction;single cell analysis;Single Nucleotide Polymorphism;single-cell RNA sequencing;Skin;System;Systemic Scleroderma;Telomerase;Testing;Therapeutic Effect;Therapeutic Intervention;therapeutic target;Tissues;transcriptome;Transforming Growth Factor beta

PROJECT_TITLE: Pathways regulating profibrotic macrophages in a novel explant model of systemic sclerosis-associated interstitial lung disease

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ORG_CITY: MILWAUKEE

ORG_DEPT: PEDIATRICS

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: The mammalian gastrointestinal tract combines a variety of influences to maintain intestinal homeostasis. We found that complement component 3 (C3), typically associated with innate inflammatory responses in circulation, was expressed in the distal small intestine (DSI) in enterocytes, Paneth cells, and fibroblasts in response to non-inflammatory commensal colonization. We aim to characterize the nature of C3 expression in the GI tract and identify novel functions of C3 by examining the role it plays in regulating bacteria and immune cells to facilitate intestinal homeostasis through non-inflammatory defense mechanisms.

PI_NAMEs: SALZMAN, NITA H (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Antigens;Bacteria;Binding;Biological Models;C3 gene;C3bi;Cells;Circulation;commensal bacteria;Communities;Complement;Complement 3;Complement 3b;complement system;Complex;Defense Mechanisms;Distal;Enterococcus faecalis;Enterocytes;Epithelial Cells;Epithelium;Fibroblasts;Future;gastrointestinal;gastrointestinal epithelium;Gastrointestinal tract structure;Gene Expression;Growth;Homeostasis;Host Defense;Host Defense Mechanism;human disease;Immune;Immune signaling;Immunoglobulin A;Inflammation;Inflammatory;Inflammatory Response;Innate Immune System;insight;Integration Host Factors;intestinal homeostasis;Intestines;Knowledge;Liver;Maintenance;Mediating;Microbe;microbial;microbial composition;mRNA Expression;Mucous Membrane;Nature;novel;Paneth Cells;pathogen;Pathology;Phagocytosis;Play;Population;protein expression;Proteins;recruit;response;Role;Sampling;Site;Small Intestines;Source;Specificity;Stimulus;Systemic infection;Tissues;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Exploring the role of C3 in intestinal homeostasis

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Pediatric

ORG_CITY: MOSCOW

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: Narrative This project will develop and evaluate educational resources about evolution using a hands on high school teaching lab. The project will also generate data on mechanisms of antifungal resistance, which is an important public health concern.

PI_NAMEs: DUNHAM, MAITREYA J;ROWLEY, PAUL A (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: Affect;anti-fungal agents;Antibiotic Resistance;Automobile Driving;Back;Bioinformatics;bioinformatics tool;Biological Sciences;Biology;career;Clinical;Collaborations;community building;Conceptions;Custom;Data;Data Analyses;data visualization;design;Discipline;Dose;Drug resistance;Education;education resources;Educational Curriculum;Educational process of instructing;emerging pathogen;Ensure;Environment;Evaluation;Evolution;experience;experimental study;Exposure to;formative assessment;Fossils;Foundations;Fungal Drug Resistance;Genes;Genetic;Genome;genome sequencing;Genomics;Head;high school;High School Student;Human Resources;improved;innovation;interest;Interview;Investigation;Laboratories;Learning;learning materials;literacy;Medicine;Modeling;Modernization;multidisciplinary;mutant;Mutation;novel;Online Systems;Organism;pathogen;pathogenic virus;Pattern;Performance;Pilot Projects;prevent;Process;Professional Competence;programs;Public Health;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resistance;resistance gene;resistant strain;Resources;Saccharomyces cerevisiae;Safety;Sampling;Schools;Scientist;Secondary Schools;Sequence Analysis;Serial Passage;Services;Site;STEM career;Students;Surveys;teacher;Teaching Materials;Testing;tool;tumor progression;Universities;user-friendly;Visualization;whole genome

PROJECT_TITLE: yEvo: a high school lab for teaching evolution and genomics


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative The goal of this research is to determine whether biomarkers of cortical physiology could be useful as an early, presymptomatic indicator of brain system dysfunction and in FTD ALS and whether it could be useful as an outcome measure for treatment trials.

PI_NAMEs: CAMPRODON, JOAN A;DICKERSON, BRADFORD C (contact);ELDAIEF, MARK CHRISTIAN

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Affect;Age of Onset;Amyotrophic Lateral Sclerosis;Atrophic;autosome;behavioral impairment;Biological Markers;biomarker identification;Brain;C9ORF72;cerebral atrophy;Cessation of life;Clinical;Clinical Course of Disease;clinical outcome measures;Clinical Trials;cohort;Data;Dementia;design;Diagnosis;Disease;efficacious treatment;Exhibits;Family;Family member;frontotemporal degeneration;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Functional Magnetic Resonance Imaging;Genes;Genetic;Goals;Impaired cognition;Individual;Inherited;Light;Link;Literature;Measurable;Measures;member;Molecular;Monitor;Motor Cortex;motor impairment;Motor Neurons;motor symptom;Multi-Institutional Clinical Trial;Mutation;mutation carrier;Nerve Degeneration;network dysfunction;neural network;Neurodegenerative Disorders;neurofilament;neurophysiology;Outcome;Outcome Measure;Paralysed;Pathogenicity;Pathologic;patient population;Patients;Pattern;Peripheral;Persons;PGRN gene;Phase;Physiological;Physiology;Pilot Projects;Plasma;Population;pre-clinical;protein TDP-43;Reporting;Research;Rest;Shapes;Structural defect;survival prediction;Symptoms;System;Techniques;Therapeutic;therapeutic development;Therapeutic Intervention;Transcranial magnetic stimulation;treatment trial;Work

PROJECT_TITLE: Cortical hyperexcitability in FTD and ALS: Exploring physiological biomarkers

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Contraception/Reproduction;Fibroid Tumors (Uterine);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Uterine fibroids are common noncancerous tumors that can cause women to have severe bleeding, pelvic pressure and pain, urinary dysfunction, and adverse pregnancy outcomes. How fibroids develop or how they can be treated without resorting to hysterectomy is not well understood, in large part because it is difficult to study in humans. Our goal in this proposal is to begin developing a better model system to study fibroid biology and test new therapies.

PI_NAMEs: TEIXEIRA, JOSE M. (contact)

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: adverse pregnancy outcome;Age;Agonist;Allografting;Animal Model;Benign;Biological Assay;Biological Models;Biology;black women;capsule;Cell Line;Cells;clinical care;clinically significant;Complex;Development;Disease;Enantone;Ethnic Origin;Etiology;Exons;experience;Fertility;Fibroid Tumor;Fumarate Hydratase;Functional disorder;Funding;Gene Expression Profile;Gene Modified;Genes;Genetic;GNRH1 gene;Goals;healthcare burden;Hemorrhage;HMGA1 gene;HMGA1a Protein;HMGA2 gene;Human;Hysterectomy;Immunocompromised Host;In Vitro;in vivo;Incidence;Individual;Infertility;Kidney;Knowledge;Laboratories;Leiomyoma;lentivirally transduced;Mediator;Modeling;Mus;mutant;Mutation;Myometrial;novel therapeutics;Oral;Oregon;overexpression;Pain;Papio;Pelvis;Phase;Phylogenetic Analysis;pressure;prevent;Primates;Proteins;Quality of life;Race;racial disparity;Reporting;reproductive;Reproductive Biology;Research;Resort;Role;scaffold;Severities;side effect;Smooth Muscle Tumor;Standardization;symptomatology;Symptoms;Testing;trait;Transcriptional Regulation;transcriptome;translational potential;Transplantation;tumor;United States;Up-Regulation;urinary;Uterine Fibroids;Uterus;White Women;Woman;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Developing a baboon model for uterine fibroids

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: This proposal seeks to elaborate how DNA repair enzymes protect against mutations caused by damage (deamination) occurring to 5-methylcytosine (mC), a modified DNA base that has essential functions in regulating gene expression. A large fraction of point mutations in cancer and genetic disease are attributable to mC deamination. The studies will reveal how repair enzymes counter this threat and inform why these mutations are still prevalent in human DNA. The studies will also reveal how these enzymes contribute to regulating the levels of DNA methylation (mC), which is important because aberrant DNA methylation is implicated in diseases including cancer, and in ageing.

PI_NAMEs: DROHAT, ALEX C (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Aberrant DNA Methylation;Aging;Animals;Archaea;Bacteria;base;Base Excision Repairs;Binding;Cytosine;Deamination;demethylation;Disease;DNA;DNA glycosylase;DNA Methylation;DNA Repair Enzymes;Ensure;enzyme activity;Enzymes;Epigenetic Process;epigenetic regulation;Excision;Face;Gene Expression;Genetic Diseases;genome integrity;Genomics;Goals;Guanine;Health;Human;human disease;human DNA;In Vitro;interest;Learning;Malignant Neoplasms;Mammals;Mediating;Methylation;Modeling;Modification;Mutation;Nature;novel therapeutic intervention;oxidation;Pathway interactions;Plants;Point Mutation;Polymerase;Post-Translational Protein Processing;Process;recruit;repair enzyme;repaired;Research;Site;Specificity;Sumoylation Pathway;System;Testing;Thymine;Uracil;Vertebrates

PROJECT_TITLE: Mechanisms of BER in Genomic Integrity and Epigenetic Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Cerebrovascular;Clinical Research;Complementary and Integrative Health;Lung;Neurosciences;Sleep Research

PHR: Project Narrative  We propose to investigate the brain-body interaction between breath-by-breath O2-CO2 exchange ratio (bER) and brain activities as a mechanism of mindfulness meditation. We plan to compare the effect of mindfulness meditation with that of spontaneous breathing at rest without mindfulness and of paced breathing at six breaths per minute. We measure physiological outcomes and use functional magnetic resonance imaging (fMRI) to map the correlation between bER and blood oxygenation level dependent signal (BOLD) changes at brain regions and networks of interest including those at the brainstem.

PI_NAMEs: CHAN, SUK-TAK ;KWONG, KENNETH K (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Affect;Age;Alveolus;Anatomy;Arousal;Attention;Awareness;basal forebrain;blood oxygen level dependent;Blood Pressure;Brain;Brain Mapping;Brain region;Brain Stem;Breathing;Carbon Dioxide;Cardiac;Cardiac Output;Cardiovascular Physiology;cerebral hemodynamics;Cerebrum;Characteristics;Clinical;Cognition;cognitive enhancement;cognitive function;Conscious;Coupling;Data;Diffusion;Elements;Emotions;evidence base;experience;Feeling;Frequencies;Functional Magnetic Resonance Imaging;Gases;Health;Health Benefit;heart function;Heart Rate;heart rate variability;Homeostasis;Hypothalamic structure;imaging approach;improved;interest;Judgment;Link;Literature;Maps;Measures;Meditation;Memory;mental state;mind body interaction;mind/body;mindfulness;mindfulness intervention;mindfulness meditation;neural circuit;neuromechanism;non rapid eye movement;novel;Outcome;Oxygen;Pattern;Perfusion;Personal Satisfaction;Physiological;Play;Relaxation;Reporting;respiratory;Respiratory Center;respiratory gas;response;Rest;Role;sex;Signal Transduction;Sinus Arrhythmia;Sleep;sleep quality;Sleep Wake Cycle;Stress;stress reduction;Thalamic structure;Variant;ventilation;volunteer

PROJECT_TITLE: fMRI of cerebral responses to breathing of  mindfulness and slow paced breathing at brainstem and higher brain

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Digestive Diseases;Infectious Diseases;Liver Disease;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Although congenital cytomegalovirus (cCMV) infection is the most common congenital infection in the US, important questions remain regarding its long-term sequelae. To address this critical knowledge gap, we propose to leverage existing data on over 29 million neonates in order to generate high-quality evidence on the risks of long-term neurologic and non-neurologic sequelae of clinically recognized cCMV and on the benefits of available treatments for these outcomes.The findings from this research will not only inform the value of universal screening, early antiviral treatments and vaccines, but will also raise awareness among patients and clinicians for this important but underrecognized congenital infection.

PI_NAMEs: ZHU, YANMIN  (contact)

PROGRAM_OFFICER_NAME: FLORESE, RUTH HUAB

PROJECT_TERMS: Address;adverse outcome;Affect;Age;Anti-viral Agents;Attention deficit hyperactivity disorder;autism spectrum disorder;Awareness;Benefits and Risks;Birth;Case Study;Child;Childhood;Clinical;Clinical Trials;cohort;congenital cytomegalovirus;congenital infection;Cytomegalovirus;Data;design;detection method;Deterioration;Development;Diagnostic tests;Disease;Early Diagnosis;early screening;Early treatment;Effectiveness;Epidemiology;epidemiology study;Equilibrium;follow-up;Foundations;Ganciclovir;Gestational Age;Grouping;Health;Hearing;hearing impairment;Hepatitis;Hepatosplenomegaly;high risk;Icterus;improved;infancy;Infant;infant infection;insight;interest;Knowledge;long-term sequelae;Longitudinal Studies;Longitudinal, observational study;Medicaid;Microcephaly;mortality;Myocarditis;Neonatal;neonatal infection;Neonatal Mortality;neonate;Neurologic;Neurological outcome;Newborn Infant;novel;Outcome;Patients;Petechiae;Population;pregnant;prevent;Prevention strategy;Primary Prevention;Privatization;Process;protective effect;Public Health;Pulmonary Inflammation;Randomized, Controlled Trials;Reporting;Research;Risk;routine practice;Sample Size;Sampling;Scanning;screening;Secondary Prevention;Signal Transduction;Symptoms;Testing;Treatment outcome;Trees;unborn child;Update;vaccine development;Vaccines;Valganciclovir;Viral;Virus;Woman

PROJECT_TITLE: Clinically Recognized Congenital Cytomegalovirus Infection and Risk of Long-Term Neurologic and Non-neurologic Complications: Evidence from a Nationwide Cohort

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: PROJECT NARRATIVE Disproportionately high incidence and rates of death from cervical cancer occur in populations where socioeconomic and geographical barriers limit access to routine gynecological clinical care. This proposal will demonstrate the feasibility of a novel screening approach for cervical cancer using a topically applied, disease- specific plasmid containing a secreted reporter protein that can be non-invasively collected in cervical fluids. If successful, this diagnostic approach is anticipated to enable highly specific, cost-effective, self-applied cervical cancer screening to facilitate targeted clinical follow up and treatment for individuals in high-risk settings associated with reduced access to routine gynecological care.

PI_NAMEs: WARRAM, JASON MORGAN (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Adult;Alkaline Phosphatase;Animal Model;Biological Assay;Black race;cancer cell;Cancer cell line;Cancer Detection;Cancer Model;Caring;Cell model;Cell secretion;Cells;Cervical;Cervical Cancer Screening;Cervix Uteri;Clinic;Clinical;clinical care;Collection;Communities;Complex;cost effective;Data;Death Rate;Detection;Development;Diagnosis;Diagnostic;Diagnostic Specificity;diagnostic strategy;Disease;Disparity;DNA;Early treatment;effective therapy;Embryo;Endocytosis;follow-up;Foundations;Fresh Tissue;Future;geographic barrier;Goals;Gynecologic;high risk;Home;Human;human tissue;In Vitro;in vivo;Incidence;Individual;Kinetics;Liquid substance;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;Methods;mortality;Mus;novel;Nude Mice;overexpression;Patients;Phase;Pilot Projects;plasmid DNA;Plasmids;Population;Production;promoter;Protein phosphatase;Proteins;rapid diagnosis;Reporter;Research;Resected;Rural;screening;Screening for cancer;Screening Result;Sensitivity and Specificity;socioeconomics;Specificity;Testing;Time;Tissues;Topical application;Transfection;Tumor Burden;tumor xenograft;Underrepresented Populations;Up-Regulation;vector;Woman;Work;Xenograft procedure

PROJECT_TITLE: A Topical Plasmid-based Approach to Cervical Cancer Screening

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetic Testing;Genetics;Heart Disease;Human Genome;Pediatric;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Heterotaxy (HTX) is a disorder of left-right (LR) patterning of the form and function of internal organs like heart, affecting 1 in 10,000 live births. We have established a collaboration between clinicians and basic scientists to recruit patients with HTX and identify candidate genes/variants using whole exome sequencing, followed by their experimental analysis to validate the genes as disease-causing and improve our understanding of the underlying disease mechanisms.

PI_NAMEs: KULKARNI, SAURABH S (contact);PEROUTKA, CHRISTINA ;RATAN, AAKROSH

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Acceleration;Address;Affect;Basic Science;Benchmarking;Biochemical;bioinformatics pipeline;Biological Assay;biomedical referral center;Birth;Candidate Disease Gene;candidate identification;Caring;Cell Physiology;Cells;CLIA certified;Clinical;Clinical Sciences;Collaborations;Complex;Computing Methodologies;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;Copy Number Polymorphism;cost;Counseling;CRISPR/Cas technology;Data;Data Set;Development;Diagnosis;Disease;disease phenotype;Embryonic Development;epidemiology study;Ethnic Origin;Etiology;exome;exome sequencing;experimental analysis;Family;Future;gain of function;Genes;Genetic;Genetic Counseling;genetic counselor;Genetic Databases;Genetic Processes;genetic testing;Goals;Heart;Homogeneously Staining Region;Human;human reference genome;improved;individual patient;Infant;insertion/deletion mutation;Institutional Review Boards;Interdisciplinary Study;Intervention;Investigation;Knock-out;Knowledge;Left;Live Birth;loss of function;Medical;Medical Genetics;meetings;model organism;Modeling;Molecular;multidisciplinary;Mutation;Organ;Outcome;Pathogenesis;Pathogenicity;Patient Recruitments;Patients;Pattern;pediatric cardiologist;Pediatric Hospitals;Phenotype;Play;Population;proband;Prognosis;Protocols documentation;Race;Rana;Recommendation;recruit;Recurrence;Reproducibility;Research;Rest;Risk;Risk Assessment;Role;Scientist;Single Nucleotide Polymorphism;Situs Inversus;System;Time;Universities;Variant;variant detection;variant of unknown significance;Virginia;Work;Xenopus

PROJECT_TITLE: Establishing Basic Science-Clinical Collaborations to Understand the Molecular Mechanisms of Heterotaxy

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The Summer Healthcare Experience (SHE) in Oncology is a virtual, multi-institutional STEM enrichment program for high school students, with a mission to increase participation of women from underrepresented backgrounds in the cancer biomedical workforce. The curriculum offers hands-on research experience, career exploration, mentorship, and leadership training, drawing strategically from the unique strengths and resources of multiple cancer centers. This proposal details plans to expand SHE in fundamental ways including year-round programming, formalized support for program alumni, and rigorous evaluation to validate and strengthen the SHE program model for expansion to new institutional cohorts nationwide.

PI_NAMEs: MEKINDA, MEGAN  (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: anti-cancer research;Attitude;Award;barrier to care;Behavioral;Binding;Biological;cancer care;Cancer Center;Cancer health equity;Cancer Science;career;career awareness;career development;Career Exploration;Case Study;Catchment Area;Chicago;Clinical;cohort;Collaborations;college;Communication;Communities;Comprehensive Cancer Center;Country;Critical Thinking;design;Diagnosis;Educational Curriculum;Educational workshop;empowerment;Enrollment;Environmental Risk Factor;Evaluation;expectation;experience;Female;Fostering;Funding;Generations;Goals;Guidelines;hands on research;health inequalities;Healthcare;high school;high school program;High School Student;Incidence;Individual;innovation;Institution;Kentucky;Knowledge;Laboratories;Leadership;Learning;Malignant Neoplasms;Medicine;Mentors;Mentorship;Michigan;Mission;Modeling;National Cancer Institute;Oncology;Outcome;Participant;Patients;peer networks;Pennsylvania;Persons;Population;Program Evaluation;programs;project-based learning;racial diversity;recruit;Reporting;Research Project Grants;Resources;Role;role model;Rural;Rural Community;rural dwellers;Science;science education;self-directed learning;Services;Shapes;Site;skill acquisition;skills;social;social health determinants;socioeconomics;Structure;Students;survivorship;Texas;Training;Universities;virtual;volunteer;Woman

PROJECT_TITLE: SHE (Summer Healthcare Experience) in Oncology


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

PHR: Although perinatal and early childhood infections are one of the greatest risk factors associated with neurodevelopmental disorders, we have a limited understanding of how systemic immune processes contribute to brain development or the etiology of these disorders. Notably, several genetic risk factors associated with immune function are also implicated in these disorders and there is increasing evidence that neuroimmune interactions between the peripheral immune system and brain during critical periods of development can have long term effects on brain function and behavior. This project seeks to elucidate the role of the adaptive immune system and inflammation in the development and function of the bed nucleus of the stria terminalis (BNST) and its associated neurocircuitry, with the goal of understanding how they contribute to normal development, as well as the pathophysiology associated with neurodevelopmental disorders.

PI_NAMEs: CLARK, SARAH MICHELLE (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Adaptive Immune System;adaptive immunity;Adoptive Transfer;Affect;Amygdaloid structure;Appetitive Behavior;Attention Deficit Disorder;autism spectrum disorder;Behavior;Behavioral;behavioral phenotyping;behavioral response;Bipolar Disorder;Brain;brain cell;Brain region;Cell Nucleus;Cell Physiology;cell type;Cells;Complex;Corticotropin-Releasing Hormone;critical period;design;Development;Diagnosis;Diagnostic;Disease;Dorsal;early childhood;Electrophysiology (science);Emotional;Environment;Environmental Risk Factor;Etiology;Female;Foundations;Fright;Functional disorder;functional plasticity;Future;genetic risk factor;Goals;Immediate-Early Genes;Immune;immune function;immune phagocytosis;Immune system;immunodeficiency;Immunohistochemistry;immunological status;Impairment;Infection;Inflammation;Inflammatory;inflammatory milieu;Investigation;Long-Term Effects;Lymphocyte;male;Mediating;member;Mental disorders;Microglia;Mus;Neonatal;neonate;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neuroimmune;Neuroimmunomodulation;Neurons;Neuropeptides;Output;Pathologic;Perinatal;Peripheral;Phagocytosis;Play;Population;postnatal development;Process;recruit;Regulation;Reporting;response;reward processing;Risk Factors;Role;Schizophrenia;sexual dimorphism;Shapes;Slice;Social Behavior;Stress;Structure of terminal stria nuclei of preoptic region;systemic inflammatory response;T-Lymphocyte;Testing;Wild Type Mouse;Work

PROJECT_TITLE: Regulation of BNST development by the adaptive immune system: implications for neurodevelopmental disorders

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: Narrative C. albicans biofilms are responsible for recalcitrant candidemia. We will spatially delineate the transcriptomic architecture of biofilm infected niche, identifying molecular signatures of both the host and the pathogen. We will test two novel FDA-approved molecules for their ability to impair biofilm growth and dissemination in vivo.

PI_NAMEs: UPPULURI, PRIYA  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Aftercare;analog;Animal Model;anti-fungal agents;aqueous;Architecture;Atlases;attenuation;Binding;Biogenesis;Biological Assay;Biological Availability;Biological Markers;biomarker identification;Biomass;Blood Circulation;Candida;Candida albicans;candida biofilm;candidemia;Candidiasis;Cardiovascular system;Caspofungin;catheter related infection;Catheters;Cell Communication;cell community;Cell Cycle;Cell Line;Cells;cofactor;combat;Complex;cytokine;Data;Development;Devices;Disseminated candidiasis;Dose;drug development;drug efficacy;Drug resistance;Dryness;efficacy evaluation;Endothelial Cells;Environment;Failure;FDA approved;Fluconazole;Formulation;Freezing;Frequencies;fungus;Gene Expression;Genes;Genetic;Genomics;Goals;Growth;Harvest;Heart;Hematogenous;Human;Image;Immune;Immune response;Immunohistochemistry;Immunologic Markers;Immunology;Impairment;improved;In Vitro;in vivo;in vivo imaging system;Individual;Infection;Invaded;Kidney;Knock-out;Knowledge;Lesion;Location;Macrophage;Maps;Measures;Medical Device;Messenger RNA;Microbial Biofilms;microorganism growth;Mitochondria;Modeling;Molecular Profiling;Monitor;mortality;mouse model;Mucous Membrane;Multi-Drug Resistance;multidisciplinary;multiplex assay;Mycoses;nanoparticle;neutrophil;new technology;novel;novel therapeutics;Oropharyngeal;overexpression;pathogen;Patient-Focused Outcomes;Pharmaceutical Preparations;Pharmacotherapy;Plasma;Predisposition;Proteins;Rattus;Refractory;Reporting;Research Personnel;Resistance;Ribosomes;Role;small molecule;Solubility;Spleen;Structure of jugular vein;success;Surface;synergism;Techniques;Technology;Testing;Therapeutic;Tissues;tool;Toxic effect;transcriptomics;vaginal infection;Vascular Endothelial Cell;Venous;Virulence Factors;Visualization;Yeasts

PROJECT_TITLE: Delineating host response to central venous catheter associated Candida albicans biofilm infections, and development of novel therapeutics to combat drug resistant biofilms

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Intervertebral disc degeneration affects nearly half of people over 40 years of age and contributes to pain and disability in affected individuals. Bone marrow stem cells delivered to the disc have can slow disc degeneration by secreting factors that help to repair the resident tissue and stave off inflammation, but current methods of cell delivery do not support the transplanted cells. We will develop gels that are tethered with small peptides that support the transplanted stem cells by promoting signaling through the insulin like growth factor receptor, and test their impact at repairing disc tissue in rats.

PI_NAMEs: HUEBSCH, NATHANIEL  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Adhesives;Affect;Age Years;Alginates;Anabolism;Animal Model;Anti-Inflammatory Agents;Apoptosis;Attenuated;Biological Models;bone;Bone Marrow Stem Cell;Bone Morphogenetic Proteins;Cell secretion;Cell Survival;Cell Therapy;Cell Transplantation;Cells;Cellularity;Chemicals;Chronic;Clinical;Coculture Techniques;Coupled;cytokine;Dangerousness;Data;Diffuse;disability;Dose;Encapsulated;Engineering;Environment;Exhibits;Exposure to;Extracellular Matrix;Extracellular Matrix Proteins;Formulation;Future;Gel;Genes;Granulocyte-Macrophage Colony-Stimulating Factor;Growth Factor;Height;Histology;Human;Hydrogels;immune cell infiltrate;improved;improved outcome;In Vitro;in vitro Model;in vivo;Individual;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;Injectable;Injury;Insulin-Like Growth Factor I;Insulin-Like Growth Factor II;Insulin-Like Growth Factor Receptor;Integrin Binding;Intervertebral disc structure;intervertebral disk degeneration;Length;Measures;Mediating;Mesenchymal Stem Cells;mesenchymal stromal cell;Methods;microCT;mimetics;nucleus pulposus;Outcome;Pain;Pathologic;Pathology;Pathway interactions;Peptide Fragments;Peptides;peptidomimetics;Periodicity;Persons;PIK3CG gene;Population;pre-clinical;prevent;Production;Protein Fragment;Puncture procedure;Rattus;regenerative therapy;repair strategy;repaired;reparative capacity;residence;response;Safety;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Somatomedins;Stem cell transplant;stem cells;Structure;Supporting Cell;targeted delivery;Technology;Testing;Therapeutic;tissue repair;Tissues;TNF gene;translational applications;Transplantation;Treatment Factor;treatment response;Water;Work

PROJECT_TITLE: Alginate Hydrogels with Tethered IGF-1 Mimicking Peptides to enhance the Therapeutic Potency of Mesenchymal Stem Cells for Intervertebral Disc Repair

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: NARRATIVE Current approaches do not have enough resolution to distinguish the heterogeneity of the identical NPs’ PC composition. In this study we aim to develop a highly sensitive MagLev system to probe the small variations in the PC composition of the same identical NPs in terms of number and/or type of the proteins.

PI_NAMEs: ASHKARRAN, ALIAKBAR  (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TITLE: Heterogeneity of protein corona (PC) composition using highly sensitive magnetic levitation (MagLev) system

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (82)]


NIH_SPENDING_CATS: Aging;Regenerative Medicine;Wound Healing and Care

ORG_CITY: ALBANY

ORG_DEPT: SURGERY

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: Project Narrative Integrin adhesion receptors on the surface of epidermal keratinocytes have critical roles in controlling the cell microenvironment and in mediating aspects of cutaneous wound healing. Integrin α3β1-dependent wound processes that were established in young mice, such as (1) timely reepithelialization and (2) induction of epidermal factors that mediate immune cell infiltration, are known to be compromised in aging skin of humans and rodents. The goal of the proposed work is to assess these wound processes in young, middle, and aged mice that express or lack epidermal α3β1, in order to determine whether α3β1-dependent functions are diminished during intrinsic (chronological) aging thereby impeding the ability to heal wounds, towards the long term goal of exploiting integrin α3β1 as a therapeutic target to promote wound repair in the elderly.

PI_NAMEs: LONGMATE, WHITNEY MORGAN (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acute;adhesion receptor;Adhesions;Adult;Age;age related;age related changes;age related decline;Age Years;aged;Aging;Area;Basement membrane;Binding;Bioinformatics;Cell Physiology;Cell Surface Receptors;Cells;chronic wound;Chronology;Clustered Regularly Interspaced Short Palindromic Repeats;comorbidity;Compensation;Cues;Cutaneous;cytokine;Data;Data Set;Defect;Dermis;Development;Elderly;Embryo;Epidermis;experience;extracellular;Extracellular Matrix;Genetic Models;Goals;Growth Factor;Health Care Costs;high risk;Human;human old age (65+);Immune;immune cell infiltrate;Immunologic Stimulation;Impaired wound healing;Impairment;improved;In Vitro;in vitro Assay;in vivo;infection rate;infection risk;innovation;Integrin alpha3beta1;Integrins;Interleukin-1 alpha;keratinocyte;Knowledge;Laminin;Ligands;Link;Macrophage;Macrophage Colony-Stimulating Factor;Mediating;middle age;migration;Modeling;Morbidity - disease rate;Motility;mouse model;Mus;Natural regeneration;old mice;paracrine;pathogen;Peptide Hydrolases;Persons;Play;Population;Process;Proliferating;re-epithelialization;receptor;recruit;Regulation;repaired;response;Rodent;Role;Sampling;Skin;Skin Aging;skin barrier;Skin injury;Skin repair;skin wound;Skin wound healing;social;Surface;System;Testing;therapeutic target;Therapeutically Targetable;Time;Tissues;transcriptome sequencing;Work;wound;wound care;wound healing;Wound healing therapy;young adult

PROJECT_TITLE: Roles of epidermal integrin α3β1 in age-dependent changes during cutaneous wound healing

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Genetics

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Genetics and microbiome, and their interaction with a wide variety of exposures ranging play a critical role development and progress of non-communicable diseases (NCD) but there are limited genetic epidemiology research in Vietnam, due in part to a lack of existing infrastructure, an existing cadre of trained investigators, and funding. This proposed Vanderbilt University Medical Center (VUMC) and Vietnamese (Hanoi Medical University [HMU] and Vietnam National Cancer institute [VNCI]) partnership will expand upon our existing partnership to establish the new Vanderbilt-Vietnam Genetic Epidemiology (V2-GENE) Training Program focused on training student in the tools needed for genetic analysis of NCDs, across types of diseases. There is shortage of trained genetic epidemiologist in low-middle income countries (LMICs) trained in genetic epidemiology, our goals with V2-GENE are to equip educators and trainees with the skills in genetic epidemiology to engage in sustainable long-term research activities in genetic studies of lifecourse and non- communicable diseases and to further solidify the collaborations and partnerships across VUMC faculty within low- and middle-income countries.

PI_NAMEs: LE, GIANG M;SHU, XIAO-OU ;TRAN, HUONG THI THANH;VELEZ EDWARDS, DIGNA R (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Accounting;Appointment;Cause of Death;Cessation of life;Collaborations;Country;Development;Disease;Doctor of Philosophy;Ensure;Epidemiology;epidemiology study;Faculty;Fostering;Future;Genetic;genetic epidemiology;Genetic Research;Genomics;global health;Goals;graduate student;Grant;Infrastructure;Lead;Life Cycle Stages;Longterm Follow-up;low and middle-income countries;Medical;member;Mentors;Mentorship;Molecular Genetics;National Cancer Institute;next generation;Outcome;Population;Postdoctoral Fellow;pre-doctoral;Program Sustainability;programs;Research;Research Activity;Research Personnel;Research Training;Resources;Scientist;Students;success;Teacher Professional Development;Trainers Training;Training;Training Activity;Training and Infrastructure;Training Programs;Universities;Vietnam;Visit;Writing

PROJECT_TITLE: VANDERBILT-VIETNAM TRAINING PROGRAM IN GENETIC EPIDEMIOLOGY

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-C (50)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE Frontotemporal dementia is the second most common cause of neurodegenerative dementia in adults under 65 years of age and is second only to Alzheimer disease in this age group. This project will leverage accurate segmentation of the thalamic nuclei from magnetic resonance imaging (MRI) and AI-based super-resolution positron emission tomography (PET) to generate sensitive imaging biomarkers for frontotemporal dementia.

PI_NAMEs: DUTTA, JOYITA  (contact);SARANATHAN, MANOJKUMAR

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Address;Adult;Age;age group;Age Years;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Architecture;Atrophic;Behavior;Behavioral;behavioral variant frontotemporal dementia;Benchmarking;Biological Markers;C9ORF72;candidate marker;Cell Nucleus;Clinical;clinical subtypes;Clinical Trials;Cognitive;cohort;contrast imaging;Control Groups;Cross-Sectional Studies;Data;Data Set;Dementia;Detection;Development;Diagnosis;Discrimination;Disease;drug development;drug discovery;Early Diagnosis;Event;Frontotemporal Dementia;Genetic;glucose metabolism;Image;imaging biomarker;Impairment;Intervention;Label;Language;Liquid substance;longitudinal analysis;Magnetic Resonance Imaging;Measures;Methods;Modeling;multi-atlas segmentation;Multimodal Imaging;multimodality;Mutation;National Institute on Aging;Nerve Degeneration;neurodegenerative dementia;nonalzheimer dementia;novel strategies;Pathogenesis;Pathologic;Patients;Play;Polynomial Models;Positron-Emission Tomography;pre-clinical;Primary Progressive Aphasia;Process;quantitative imaging;Research;response;ROC Curve;Role;Scheme;self supervised learning;spatiotemporal;specific biomarkers;Specificity;Staging;tau Proteins;Techniques;Thalamic Nuclei;Thalamic structure;Therapeutic;ultra high resolution;Variant;Writing

PROJECT_TITLE: Super-Resolved Multimodal Imaging Biomarkers for Frontotemporal Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-Q (81)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: HERBERT H. LEHMAN COLLEGE

PHR: Project Narrative The Bronx has a long history of experiencing health disparities including diabetes, asthma, STDs/HIV, sleep disparities and more. Underserved communities urgently need health investigators that understand their communities. This project develops educational activities for pre-college Bronx students to pursue studies in research using a place based educational approach.

PI_NAMEs: APONTE, JUDITH ;ROLDOS, ISABEL M (contact)

PROJECT_TERMS: Address;Affect;Asian;Asthma;Attention;Behavioral Sciences;Black race;burden of illness;career;Career Choice;Career Mobility;Cities;cohort;Collaborations;college;Communities;Community Health;COVID-19;Data;Data Science;design;Development;Diabetes Mellitus;Discipline of Nursing;Disparity;Education;Educational Activities;Educational workshop;Engineering;Evaluation;experience;Faculty;Feedback;Focus Groups;Fostering;Goals;Health;Health Disparities Research;health disparity;health equity;Health Occupations;Health Sciences;Health Services;high school;High School Faculty;High School Student;Hispanic Populations;Hispanic-serving Institution;HIV/STD;Home;Individual;Injury;Institution;intersectionality;Learning;learning community;Measures;medical schools;Medicine;Mental Health;Mentorship;Minority;minority communities;minority investigator;Minority-Serving Institution;Mission;New York;New York City;Not Hispanic or Latino;Outcome;Participant;Pathway interactions;peer;Phase;Population;Positioning Attribute;programs;Public Health;Quantitative Reasoning;Questionnaires;Recording of previous events;Reduce health disparities;Research;Research Methodology;Research Personnel;research study;Schools;Science;Scientist;Series;Sleep;Sleep Disorders;student participation;Students;summer research;System;teacher;Teacher Professional Development;Technology;theories;tool development;Training;Training Activity;Training Programs;tutoring;Underrepresented Minority;Underrepresented Populations;underserved community;United States National Academy of Sciences;United States National Institutes of Health;Universities;university student

PROJECT_TITLE: Using place-based education to engage Bronx high schoolers and teachers in health disparity research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (55)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Substance Misuse

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative This is a planning proposal for a Brain Circuits RO1 examining the biological mechanisms of attention in the framework of meta-reasoning, using novel high precision measurements of neuromodulator release. The results will provide insights into the cellular mechanisms of attention control with high relevance for decision making and psychiatric disease.

PI_NAMEs: FERRERA, VINCENT P;GOTTLIEB, JACQUELINE  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TITLE: A Biological Theory of Attention Control in the Framework of Rational Meta-Reasoning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-W (55)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Hematology;Kidney Disease

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative Impaired kidney oxygenation is often identified as a common denominator of deteriorated kidney function in a variety of kidney diseases, such as acute kidney injury, chronic kidney disease, and its transition to end-stage renal failure. Noninvasive measurement and quantification of renal tissue oxygenation is crucial for clinical management and treatment. This work will develop motion-robust, fully ungated free-breathing abdominal MRI for quantification of renal oxygen extraction fraction.

PI_NAMEs: KEE, YOUNGWOOK  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: 3-Dimensional;Abdomen;absorption;Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Adipose tissue;Adult;Algorithms;Anoxia;Antineoplastic Agents;Area;Binding;Biological Markers;Blood;Blood flow;blood oxygen level dependent;Blood Vessels;Body Image;Brain;Breathing;bulk motion;Cancer Patient;cancer therapy;Cardiac Output;Cerebrum;Characteristics;chemotherapeutic agent;Chronic Kidney Failure;Cisplatin;Clinical;Clinical Management;Clinical Treatment;Communities;Compensation;Cone;Consumption;Creatinine;data acquisition;deoxyhemoglobin;Deterioration;Development;Dimensions;Dissociation;dosage;Dose;early detection biomarkers;End stage renal failure;Environment;Equilibrium;experience;Fatty acid glycerol esters;Freezing;Functional Magnetic Resonance Imaging;Furosemide;Goals;Hematological Disease;Hemoglobin;Human;human subject;Hypoxia;Image;Image Analysis;image reconstruction;imaging biomarker;Imaging Device;imaging study;Impairment;in vivo;Injections;Injury to Kidney;innovation;interstitial;Investigation;Joints;Kidney;kidney cortex;Kidney Diseases;kidney dysfunction;kidney imaging;kidney medulla;Magnetic Resonance Imaging;Magnetism;male;Maps;Measurement;Methodology;Methods;Minor;Modeling;Motion;Motivation;multidisciplinary;Nephrology;nephrotoxicity;non-invasive monitor;Normal tissue morphology;Organ;Osmosis;Oxygen;Oxygen Consumption;Oxyhemoglobin;Papillary;Partial Pressure;Pathologic;Pathway interactions;Patients;Perfusion;Pharmaceutical Preparations;Phase;Physicians;Physiological;Platinum;Population;preclinical study;Predisposition;preservation;Protocols documentation;quantitative imaging;radiologist;Regimen;renal damage;Renal function;Renal Tissue;Research;Resolution;respiratory;Scanning;Serum;Signal Transduction;solute;Techniques;technology development;Therapeutic;tissue oxygenation;Tissues;Urologic Diseases;Venous;Water;Work

PROJECT_TITLE: Noninvasive Measurement of Voxelwise Renal Oxygenation Using Quantitative Susceptibility Mapping

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The goal of this proposal is to determine the mechanism by which G protein coupled receptors (GPCRs) respond to neurotransmitters and hormones, and modify the function of cells by activating G proteins, kinases and arrestins. This information will facilitate the process of drug discovery for GPCRs, which are the largest family of membrane proteins in the human genome. Drugs acting on GPCRs can have an impact on a broad spectrum of diseases including neurologic and psychiatric disorders, Alzheimer’s disease, cardiovascular disease, pulmonary disease, inflammation, diabetes, and obesity.

PI_NAMEs: KOBILKA, BRIAN K (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Adverse effects;Agonist;Alzheimer's Disease;antagonist;Arrestins;Behavior;Binding;biophysical techniques;Cardiovascular Diseases;Cell Physiology;Complex;Cryoelectron Microscopy;Diabetes Mellitus;Disease;drug action;drug discovery;Exhibits;Family;Funding;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Goals;GTP-Binding Proteins;Hormones;Human Genome;Inflammation;insight;Ligands;Lung Diseases;Membrane Proteins;Mental disorders;Metabolic Diseases;Methods;Molecular Conformation;Nervous System Disorder;Neurotransmitter Receptor;Neurotransmitters;new therapeutic target;Obesity;Pathway interactions;Pharmaceutical Preparations;Phosphotransferases;Physiological;Process;Protein Dynamics;Research;Resolution;Signal Pathway;Signal Transduction;Structure;Therapeutic Effect

PROJECT_TITLE: G protein coupled receptor structure, dynamics, and signaling.

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-D (35)]


NIH_SPENDING_CATS: Clinical Research;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_NAME: SAN FRANCISCO STATE UNIVERSITY

PHR: The Scientist Spotlights Partnership Program: Engaging High School Students in Exploring Biomedical Science Careers by Connecting  with Counter-Stereotypical Scientists Project Narrative The Scientist Spotlights Partnership Program aims to promote high school students’ science identity, relatability to scientists, and interest in biomedical science careers by engaging them in interviewing biomedical scientists and authoring Scientist Spotlights, which are curricular supplements highlighting the stories of counter-stereotypical scientists that can be used to teach science content standards. To investigate the impact of engaging high school students in authoring Scientist Spotlights, we will partner high school teachers with near peer undergraduate student mentors from diverse backgrounds who will together guide high school students through the authoring process and collaborate on assessing the impact on students’ science attitudes and career interests. Over 5 years, we aim to collaborate with ~40 science teachers, ~80 near peer undergraduate mentors, and ~1280 high school students who will author ~640 peer-reviewed biomedical Scientist Spotlights that will be disseminated, along with research results, through the free, online, and open access Scientist Spotlights Initiative website. 1

PI_NAMEs: TANNER, KIMBERLY D. (contact)

PROJECT_TERMS: Attitude;Biology;Biomedical Research;biomedical scientist;career;Career Choice;career development;Collaborations;college;Color;Development;Educational Curriculum;Educational process of instructing;experience;Faculty;Funding;high school;High School Faculty;High School Student;insight;interest;Interview;marginalized population;Mentors;peer;peer coaching;Peer Review;Process;programs;Research;role model;San Francisco;Science;science teacher;Scientist;Stereotyping;student mentoring;Students;teacher;undergraduate student;United States National Institutes of Health;Universities;web site;Work

PROJECT_TITLE: Scientist Spotlights Partnership Program: Connecting High School Students with Science Role Models through Authoring Inclusive Curriculum Supplements


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Pediatric

ORG_CITY: PORTLAND

ORG_DEPT: DENTISTRY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The program, termed Walk IN Dental Oral Ways of Science (WINDOWS), builds upon our successes with recently funded undergraduate/postdoctoral research training programs, and is tailored to address the oral health disparities present throughout the state of Oregon. Through a variety of outreach activities, in class experiences, and research internships our program will further enlighten learners about dental, oral and craniofacial health and disease and bolster the competitiveness of our trainees as they pursue advanced education. The program will open the windows for students to see the many different possibilities for future careers in dentistry and dental, oral, and craniofacial research.

PI_NAMEs: GOOLSBY, SUSIE ;LAMPI, KIRSTEN JEANNE (contact)

PROJECT_TERMS: Address;Assessment tool;Awareness;Back;Biomedical Research;career;career awareness;Career Choice;career development;Cities;Clinical;clinical care;Communities;Community Health;Country;craniofacial;craniofacial development;Dental;Dental Faculty;Dental Materials;Dental Research;Dental Schools;Dental Staff;Dentistry;Disease;Diverse Workforce;Education;Educational Activities;Educational process of instructing;Equity;Ethnic Population;Evaluation;Event;experience;Faculty;Funding;Future;Goals;Head Start Program;Health;health disparity;Health Professional;Health Sciences;Healthcare;high school;high school program;High School Student;Immunology;improved;innovation;Integrative Medicine;Internships;Knowledge;Laboratory Research;Lead;Mentors;Modeling;next generation;Oral;Oral health;Oral Microbiology;Oregon;Outcome;outreach;Participant;Pathway interactions;peer;peer coaching;Postdoctoral Fellow;programs;promote resilience;Public Health;Qualifying;racial population;Research;research based learning;Research Personnel;Research Training;Role;School Dentistry;Schools;Science;Scientist;skills;Students;success;summer research;teacher;Time;time use;Tissue Engineering;tool;training opportunity;Training Programs;undergraduate student;Universities;Walking;Work

PROJECT_TITLE: Opening WINDOWS for high school learners to see and explore dentistry and dental research careers


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative A significant correlation exists between inflammation, defects in chondrocyte proliferation, and cartilage repair in osteoarthritis (OA) patients and animal models. In this study, we will exploit the immunoregulatory mechanisms in play during the embryo development to develop a novel therapeutic to treat OA by utilizing multi-tissue organoid (MTO)-derived exosomes to regulate inflammation and promote chondrocyte proliferation, which will facilitate cartilage repair to alleviate the symptoms and arrest disease progression.

PI_NAMEs: O'BRIEN, TIMOTHY D;RAMACHANDRAN, SABARINATHAN  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: adaptive immune response;Adrenal Cortex Hormones;Affect;Age;aged;aggrecan;Analgesics;Animal Model;Anti-Inflammatory Agents;Antiinflammatory Effect;arthropathies;articular cartilage;Autopsy;Back;Biological;Biological Assay;biological systems;Cartilage;cartilage repair;CD4 Positive T Lymphocytes;Cell Culture Techniques;Cell Survival;Cell Therapy;Cell Transplantation;Cells;cGMP production;Characteristics;Chemicals;Chondrocytes;Chronic;Clinical;clinical development;clinical translation;Clinical Trials;Collagen Type II;Conditioned Culture Media;Control Groups;cytokine;Defect;Degenerative polyarthritis;Development;Disease;Disease Progression;economic impact;effector T cell;Embryonic Development;Engraftment;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Equilibrium;Evaluation;exosome;extracellular vesicles;FDA approved;Female;Fetal Development;fibroblast growth factor 18;Funding;Future;Genetic Transcription;Growth Factor;Hand;Hip region structure;Human;human model;Hyaluronic Acid;Immune;Immune system;Immune Tolerance;Immunity;immunogenicity;Immunohistochemistry;immunoregulation;In Vitro;in vivo;Incidence;induced pluripotent stem cell;Inflammation;inflammatory marker;Injections;Interleukin-6;Intra-Articular Injections;Intrinsic factor;Joint Instability;Joints;Knee;Lead;Lesion;Lymphocyte;male;manufacture;manufacturing process;MAPK8 gene;men;Meniscus structure of joint;mesenchymal stromal cell;Metalloproteases;Methods;MicroRNAs;Mitotic Activity;Modeling;neutralizing antibody;novel;novel therapeutics;Nucleic Acids;Obesity;Operative Surgical Procedures;Opioid;Organoids;pain relief;Pathology;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Persons;Physical therapy;Play;Population;programs;Proliferating;proliferation potential;Proteins;Proteomics;Rattus;reduce symptoms;regenerative;Regulation;Regulatory T-Lymphocyte;Replacement Arthroplasty;Resolution;response;Role;salt balance;Severity of illness;Shipping;Side;Signal Transduction;Source;Surface;Symptoms;Synovial Fluid;Testing;Therapeutic;Time;Tissues;Transcription Alteration;transcriptomics;Tumorigenicity;Woman

PROJECT_TITLE: Development of an Organoid-Derived Exosome Product for the Treatment of Osteoarthritis


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Precise connections between neurons in the brain are needed for understanding sounds and localizing their sources. Defects in brain circuits that process sounds can lead to language difficulties and problems with sound perception. This project will explore new mechanisms that help form these brain circuits during development.

PI_NAMEs: CRAMER, KARINA S (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acceleration;Acoustic Nerve;Anatomy;Apoptosis;Apoptotic;Appearance;Auditory;Auditory Brainstem Responses;auditory pathway;Auditory Perception;Auditory system;Axon;Brain;Brain Stem;CASP3 gene;Categories;Cell Nucleus;Cells;Chick Embryo;Cochlea;Communication;Defect;Dendrites;Development;Electrophysiology (science);Electroporation;Embryo;Embryonic Development;exosome;extracellular vesicles;Ganglia;Genes;Goals;Hearing;Hearing Tests;Impairment;Language;Mediating;Modeling;Molecular;monolayer;Nerve;neural circuit;Neurons;Neurosciences;novel;Ontology;Pathway interactions;Peptide Hydrolases;pharmacologic;Plasmids;postsynaptic;Process;Property;Proteins;Proteolysis;Proteome;Proteomics;Regulation;Research;Role;Sampling;Site;Slice;sound;Source;Structural defect;Synapses;Synaptic plasticity;Synaptic Potentials;Systems Development;tandem mass spectrometry;Testing;Time;Transplantation;vesicular release;Work

PROJECT_TITLE: Non-Apoptotic Functions of Caspase-3 in Brainstem Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-A (02)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: The SARS-CoV-2 pandemic has claimed 6.9 million lives with 767 million people infected world-wide. While vaccines are generally effective to prevent viral infection, antiviral drugs provide an alternative and effective mean to treat COVID-19 and post-COVID syndromes including lung and kidney complications. In this study, we use a novel fission yeast and human cell-based system to discover SARS-CoV-2 ORF3a inhibitors with a goal to develop new antiviral drugs that can be used to treat COVID-19 and post-COVID complications.

PI_NAMEs: ZHAO, RICHARD YUQI (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Anti-viral Agents;antiviral drug development;Apoptotic;Biological Models;Biology;cDNA Library;Cell Death;cell injury;Cells;Clinical;clinically relevant;Containment;COVID-19;COVID-19 pandemic;COVID-19 severity;COVID-19 treatment;cytokine;cytokine release syndrome;Death Rate;Development;Disease;drug discovery;drug resistance development;drug testing;Effectiveness;emerging virus;experience;FDA approved;Fission Yeast;Foundations;genome-wide;genome-wide analysis;Goals;high throughput screening;high-throughput drug screening;Human;Human Cell Line;Immune response;Infection;Inflammasome;Inflammation;Inflammatory;inhibitor;insight;Interleukin-6;Kidney;kidney epithelial cell;Lead;Link;Long COVID;Lung;Mammalian Cell;Mediating;Medicine;Molecular;mutant;NF-kappa B;novel;Oxidative Stress;Pathway interactions;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Play;post COVID-19 complications;prevent;Process;Production;Proteins;Research;Role;Running;screening;Severe Acute Respiratory Syndrome;small molecule inhibitor;Specialist;Structure-Activity Relationship;success;System;Systems Integration;Testing;Therapeutic;therapeutic target;Time;Tissues;TNF gene;Up-Regulation;Vaccines;Variant;Viral;Viral Pathogenesis;virology;Virus Diseases;Yeasts

PROJECT_TITLE: A Novel Cell-based System for the Search of SARS-CoV-2 ORF3a Inhibitors against COVID-19


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Prevention;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative This project will investigate how different environmental, personal and disease related factors contribute to the experience of behavioral symptoms of patients with Alzheimer's disease. Findings from this project will aid development of strategies and treatment to reduce or help manage disease-symptom burdens for persons with Alzheimer's disease and their family caregivers.

PI_NAMEs: PICKERING, ANDREW MICHAEL;PICKERING, CAROLYN E ZIMINSKI (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease patient;Attention;Automobile Driving;behavior prediction;Behavior Therapy;Behavioral;Behavioral Symptoms;Biological Factors;Blood specimen;Blood Vessels;Caregiver Burden;caregiver depression;Caregivers;caregiving;Caucasians;Clinic;clinical biomarkers;clinical development;Data;Dementia;Development;diaries;Disease;Disease Management;effective intervention;effective therapy;Elder Abuse;Enrollment;Environmental Exposure;Environmental Risk Factor;Ethnic Origin;Etiology;Excision;experience;falls;Family Caregiver;Frequencies;Genetic;Herpesvirus 1;Heterogeneity;Hispanic;Individual;individual variation;Infection;Inflammation;innovation;Intervention;Investigation;longitudinal design;Longitudinal Studies;Measures;microbiome;microbiota;Modeling;multilevel analysis;Mus;Neurofibrillary Tangles;novel;Nursing Homes;Outcome;Pathway interactions;Patient Monitoring;Patients;Pattern;personalized approach;Persons;Pharmaceutical Preparations;pharmacologic;Pilot Projects;prevent;Probability;rate of change;recruit;Reporting;Research;response;Role;Sampling;Severities;Severity of illness;stool sample;stressor;Symptom Burden;symptom management;Symptoms;System;systemic inflammatory response;Testing;Therapeutic;Time;Training;Translational Research;Treatment outcome;Variant;Visit;Writing

PROJECT_TITLE: Biological and environmental factors driving behavioral symptoms in Alzheimer's disease