NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Dietary Supplements;Genetics;Heart Disease;Nutrition;Pediatric;Prevention;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE We propose investigating whether defective miRNA buffering underlies the phenotypic variability observed in 22q11.2 deletion syndrome. The results of these experiments will provide a new mechanistic understanding of the interaction of genes and environment, which can be directly translated to the prevention of congenital disabilities in 22q11.2 deletion syndrome.

PI_NAMEs: ZOHN, IRENE E (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: ALDH1A2 gene;Benign;Buffers;Cardiac;Congenital Abnormality;Congenital Heart Defects;Data;Defect;Development;Dietary intake;Dietary Supplementation;differential expression;DiGeorge Syndrome;disability;Disease;Dose;Embryo;Embryonic Development;Ensure;Environment;Environmental Risk Factor;Enzymes;Essential Genes;Exhibits;experimental study;Exposure to;Feedback;Gene Deletion;Gene Dosage;gene environment interaction;gene interaction;Genes;Genetic;Goals;Heart;Heterozygote;Human;Incidence;insight;Intake;malformation;Mediating;Mediator;Methods;microdeletion;MicroRNAs;model organism;mother nutrition;mouse model;mutant;novel;Outcome;Pathway interactions;Patients;Penetrance;Phenocopy;Phenotype;Play;Pregnancy;prevent;Prevention;progenitor;Recommendation;Regulation;Research;Resistance;RNA;Role;Sampling;Series;Signal Transduction;Signal Transduction Pathway;Structural Congenital Anomalies;Supplementation;Syndrome;System;Teratogens;Testing;Time;Translating;Tretinoin;Vitamin A

PROJECT_TITLE: miRNA buffering mechanisms and phenotypic variability in genetic syndromes

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Metabolic diseases, such as obesity, type II diabetes, and atherosclerosis are often the result of multi-system changes at the organ, cell, and intracellular level. While one of the key drivers of metabolic disease is elevated plasma lipid levels, less is known on the molecular underpinnings that occur during lipid accumulation. This proposal will investigate how specific changes in the peroxisome drive lipid homeostasis and inter-organelle responses, allowing for an advanced understanding of intracellular communication in both healthy and diseased states.

PI_NAMEs: SMITH, EMILY ANN (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Activities of Daily Living;Adult;Affect;Animals;Atherosclerosis;Bile Acid Biosynthesis Pathway;bile acid metabolism;Bile Acids;Binding;Biogenesis;Biological Assay;California;Cardiometabolic Disease;Cause of Death;Cell Physiology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;comparison control;Complement;Data;Dependovirus;Detergents;Diet;Disease;Doctor of Philosophy;Drug Metabolic Detoxication;Endoplasmic Reticulum;Enzymes;Equilibrium;Ethers;experimental study;fatty acid oxidation;Fatty Acids;Generations;Genes;Genus Hippocampus;Hepatic;Hepatocyte;High Fat Diet;Histology;Homeostasis;Hybrids;Immunofluorescence Immunologic;In Vitro;in vivo;in vivo fluorescence imaging;Inbred Strain;Inbred Strains Mice;Individual;insight;Link;lipid metabolism;Lipids;Lipoproteins;liquid chromatography mass spectrometry;Liver;Los Angeles;mature animal;Measures;Membrane;Mentors;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;Molecular;Morphology;Movement;Mus;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Organ;Organelles;oxidation;Oxygen Consumption;peroxisome;Persons;Phospholipids;Physiological Processes;Plasma;Plasmalogens;Play;Positioning Attribute;Process;programs;Protein Family;Proteins;Proteomics;Reactive Oxygen Species;Regulation;Resources;Respiration;response;Rodent;Role;Satellite Viruses;Signal Transduction;Signaling Molecule;supportive environment;System;Systems Biology;Testing;Thinness;United States;Universities;Weight Gain;Western Blotting;western diet

PROJECT_TITLE: Dissecting the Role of Peroxisomal PEX Family Proteins in Hepatic Bile Acid and Lipid Metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-2 (O1)]


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative The regulation of protein homeostasis is a crucial for all life, especially in nervous systems. Among mollusks, octopuses seem to have coevolved in these systems through a unique modification to the species’ ribosomes which improves translation accuracy, with broad implications for also improving proteostasis. This project aims to characterize this evolved novelty on a molecular level and the adaptive impact it has for broader phenotypes we see in these vastly intelligent and complex animals.

PI_NAMEs: HAN, RICHARD  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Active Sites;Affect;Age;aging related;Alzheimer's Disease;Animals;Aplysia;Bacteria;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Catalytic Domain;Cell Physiology;Cephalopoda;Chemicals;Cognitive;Comparative Biology;Complex;Cryoelectron Microscopy;deacylation;Defect;Disease;Engineering;Enzymes;experimental study;Firefly Luciferases;Fractionation;Genetic;Genetic Models;Goals;improved;In Vitro;in vivo;Invertebrates;Lead;Life;Measures;Mediating;Messenger RNA;misfolded protein;Modeling;Modification;Molecular;Molecular Conformation;mutant;Mutation;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;neuron loss;neuronal survival;Neurons;neurotoxicity;Newborn Infant;novel;Octopus;Optic Lobe;Organism;Parkinson Disease;Pathogenesis;Phenotype;Play;protein aggregation;Protein Biosynthesis;protein folding;protein function;protein misfolding;Proteins;proteostasis;proteostasis loss;proteotoxicity;Radiolabeled;reconstitution;Regulation;Reporter;Resistance;Ribosomal RNA;Ribosomes;RNA, Ribosomal, 28S;Role;Site;Spinocerebellar Ataxias;Squid;Stains;Stress;stressor;Structure;System;Testing;Transfer RNA;Translating;Translations;Western Blotting;yeast genetics;Yeasts

PROJECT_TITLE: Biological Novelty through Adaptive Protein Synthesis in the Octopus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Barrett's esophagus (BE) is the only known precursor lesion for esophageal adenocarcinoma and little is known about the progression from intestinal metaplasia to dysplasia. Here, we probe the molecular drivers of this transition to dysplasia with unprecedented resolution using a combined approach of single-cell RNA sequencing, mitochondrial mutational clone tracking and 3D epithelial culture systems. Results of this work will provide new diagnostic and therapeutic targets for dysplastic BE to prevent development of esophageal adenocarcinoma.

PI_NAMEs: MUIR, AMANDA BROOKE;SHAFFER, SYDNEY  (contact)

PROGRAM_OFFICER_NAME: KLAPPROTH, JAN-MICHAEL AXEL

PROJECT_TERMS: 3-Dimensional;antagonist;APC mutation;Automobile Driving;Barrett Esophagus;Bioinformatics;Biological Models;Biopsy;Cancer Diagnostics;cell type;Cells;Cellular biology;Clinical;Clonal Evolution;Clonal Expansion;Clonality;Couples;Data;Development;Diagnosis;diagnostic biomarker;differential expression;driver mutation;Dysplasia;Dysplasia in Barrett's Esophagus;Endoscopy;Engineering;Epithelium;Esophageal Adenocarcinoma;Esophageal Intraepithelial Neoplasia;Esophageal Tissue;Event;Evolution;exome sequencing;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Genomics;Goals;Growth;Histologic;Histopathology;Human;human tissue;In Vitro;Incidence;insight;Intestinal Metaplasia;Investigation;Lesion;LGR5 gene;Libraries;Malignant neoplasm of esophagus;Malignant Neoplasms;Mitochondria;mitochondrial genome;Modeling;Molecular;Molecular Abnormality;Molecular Biology Techniques;Molecular Probes;Monitor;Mutation;new therapeutic target;novel diagnostics;novel strategies;novel therapeutics;Oncogenic;Organoids;Outcome;Pathway interactions;Patients;Pattern;Population;premalignant;prevent;Research;Resolution;RNA;Role;Sampling;Series;single cell genomics;single-cell RNA sequencing;Stains;System;targeted cancer therapy;Techniques;Technology;Testing;therapeutic target;Time;Tissues;Transcription Alteration;transcriptome;transcriptome sequencing;transcriptomics;Trees;tumorigenesis;Work

PROJECT_TITLE: Single-cell mitochondrial mutation lineage tracing of non-dysplastic and dysplastic Barrett's esophagus

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CLEVELAND

ORG_DEPT: PEDIATRICS

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative  The overarching goal of the Research and Education towards Solutions for Late effects to Innovate, Excel, and Nurture after chronic Graft-versus-Host Disease (RESILIENT after cGVHD) consensus conference is to address the state of the science, recommendations for clinical care, and research priorities for pediatric survivors of Hematopoetic cell transplantation (HCT) diagnosed with cGVHD. The conference will be divided into four sections, each led by a working group: Phases of Chronic GVHD, Organ Dysfunction and Immunity, Metabolism, Growth and Development, and Patient Important Outcomes. Preliminary reports of the working groups will be open for discussion over a one day conference for stakeholders on the HCT community.

PI_NAMEs: ROTZ, SETH J (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Acceleration;Address;Adrenal Cortex Hormones;Adult;Aging;Allogenic;American;Area;Attention;Awareness;Basic Science;Blood;Body Composition;Bone Marrow Transplantation;Canada;cardiometabolism;Cardiotoxicity;career;Cell Therapy;Cell Transplantation;Child;Childhood;chronic graft versus host disease;Chronic Phase;clinical care;clinical implementation;clinical practice;Clinical Trials;Cognition;cognitive development;cognitive performance;Collaborations;Communities;Consensus;cost;Credentialing;Critical Illness;Development;Diagnosis;diagnostic tool;Education;Ensure;Epidemiology;Ethnic Origin;experience;Family;Fostering;frailty;Functional disorder;Funding;Gender;Geographic Locations;Goals;graft vs host disease;Growth;Growth and Development function;Guidelines;Health system;Immune;immune reconstitution;Immunity;Impairment;improved outcome;infection risk;innovation;international center;Late Effects;Lead;Life;Life Expectancy;Location;Long-Term Survivors;Lung;Malignant Neoplasms;Manuscripts;meetings;member;Mental Health;Metabolic syndrome;Metabolism;National Institute of Child Health and Human Development;North America;Nurses;Organ;Outcome;Patient-Focused Outcomes;Patients;Pediatric Hospitals;pediatric patients;Peer Review;Pharmacists;physical therapist;Physician Assistants;Physicians;programs;Psychologist;Publications;Pulmonary function tests;Pulmonary Valve Insufficiency;Quality of life;Race;Recommendation;Recovery;Reporting;Research;Research Priority;Risk;Role;Science;skeletal;Societies;Socioeconomic Factors;success;Survivors;survivorship;symposium;Texas;Therapeutic;transplantation therapy;United States;United States National Institutes of Health;Vaccination;working group

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-G (O3)]


NIH_SPENDING_CATS: Aging;Diabetes;Genetics

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Across the globe, 537 million individuals are diagnosed with diabetes and in the United States, the prevalence has steadily increased from 2001 to 2020. This project aims to study the gene regulatory mechanisms of β-cell identity, function, and senescence mediated by the epigenetic regulator, Rnf20, with the overall goal of identifying factors involved in the maintenance of healthy insulin-producing β-cells. Our findings will provide a better understanding of the factors and pathways that maintain β-cell function, which is crucial for the development of novel diabetes therapies that can mitigate comorbidities associated with diabetes.

PI_NAMEs: PIERRE, TANYA H (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Activities of Daily Living;Adult;Affect;age related;Aging;Alabama;American;Apoptosis;Apoptotic;Appearance;ATAC-seq;Beta Cell;beta-Galactosidase;biological adaptation to stress;Biological Markers;Blood Glucose;blood glucose regulation;Cardiovascular Diseases;catalyst;CDKN2A gene;Cell Aging;Cell Cycle;Cell Cycle Regulation;Cell Physiology;Cell Proliferation;Cells;Chromatin;chromatin immunoprecipitation;Chronic;Communities;comorbidity;Complex;Critical Thinking;cytokine;Data;Deposition;derepression;Development;Diabetes Mellitus;diabetes mellitus therapy;diabetes pathogenesis;diabetic;Diagnosis;differentiation protocol;DNA Damage;endoplasmic reticulum stress;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;epigenetic regulation;Etiology;Excision;Faculty;Fasting;Functional disorder;functional loss;Future;Gene Activation;Gene Expression;gene function;Genes;Genetic Transcription;Glucose Intolerance;glucose tolerance;Goals;Health;high risk;Histones;homeodomain;Homeostasis;Homo;Human;Immunofluorescence Immunologic;Impairment;Incidence;Individual;inhibitor;Injury to Kidney;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;Investigation;islet;Learning;Link;Maintenance;Mediating;member;Messenger RNA;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Oxidative Stress;p19ARF;Pathway interactions;Patients;pharmacologic;Physiological;Plasma;Prevalence;Process;Proliferating;promoter;Publishing;Regulation;Repression;Research;restoration;Ring Finger Domain;Role;Scientist;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Stains;Structure of beta Cell of islet;Technical Expertise;Testing;Therapeutic;Training;transcription factor;transcription factor S-II;type I and type II diabetes;ubiquitin ligase;United States;Universities;Up-Regulation;Work

PROJECT_TITLE: Elucidating the Role of the Rnf20 Histone Modifier in Pancreatic Beta Cell Function and Senescence


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Services;Infectious Diseases;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Primary Health Care;Urologic Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Primary care physicians are at the front lines of care for the growing population of patients with Alzheimer’s disease and related dementias (ADRD), but they must often make treatment decisions without convincing empirical evidence. This study will use electronic health record data to rigorously evaluate three treatment decisions made in primary care for patients with cognitive decline: referral to specialty care, prescription for the antidementia drug memantine, and treatment of urinary tract infections. The project will prepare the student for a research career focused on improving clinical care for individuals with ADRD by leveraging real-world data to inform clinical guidelines for dementia care.

PI_NAMEs: FERGUSON, ERIN LAURA (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acceleration;Address;Affect;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Antibiotics;Area;Benefits and Risks;Black Populations;California;career;career development;Caring;Clinic;Clinical;clinical care;clinical decision-making;Clinical Informatics;Cognitive;Data;Decision Making;Dementia;dementia care;design;Development;Diagnosis;Disease;Drug resistance;Early Diagnosis;Early treatment;econometrics;efficacy evaluation;electronic health data;Electronic Health Record;Environment;Epidemiology;Escherichia coli;Escherichia coli drug resistance;Evaluation;experience;Failure;falls;Family;follow-up;frailty;Future;Goals;Grant;Guidelines;Health;health inequalities;Healthcare Systems;Heterogeneity;Impaired cognition;improved;indexing;Individual;infection management;innovation;instrument;Intervention;Knowledge;Latino Population;Lead;Link;Longterm Follow-up;Masks;medical specialties;Memantine;Memory;Mentors;Mentorship;Methods;Mission;Modernization;novel;older adult;Older Population;older women;Outcome;Patient Care;patient population;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Physicians;Population Heterogeneity;preference;prevent;Primary Care;primary care clinic;primary care patient;Primary Care Physician;primary care provider;Provider;Public Health;Quality of Care;Quality of life;Quasi-experiment;randomized trial;Recommendation;Records;Research;Research Design;Research Personnel;Resistance;Risk;safety net;San Francisco;Specialist;Students;tool;Training;translational scientist;treatment strategy;trial design;Uncertainty;Universities;Urinary tract infection

PROJECT_TITLE: Evaluating routine clinical decisions in providing primary care for people living with Alzheimer's Disease or Alzheimer's Related Disorders: using electronic health records to provide timely evidence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE Alzheimer's disease is characterized by cognitive impairment and memory loss, however, the precise constellation of symptoms, the age at which they start, and the rate of decline can vary widely between patients. This study will address one potential contributor to clinical heterogeneity in Alzheimer's by studying factors which affect amyloid neuropathology thought to be an early hallmark of disease, and how differences in amyloid formation may impact cells in the brain and their ability to support learning and memory.

PI_NAMEs: JANKOWSKY, JOANNA L (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Address;Affect;Age;Alzheimer's Disease;Amyloid;amyloid formation;amyloid pathology;amyloid precursor protein processing;amyloid structure;Animal Model;Animals;Binding;Biological Assay;Brain;Brain Pathology;cell type;Cells;Clinical;clinical heterogeneity;cognitive function;cognitive testing;Data;density;Deposition;Diffuse;Disease;disease heterogeneity;Dyes;Electron Microscopy;Enzymes;Equilibrium;excitatory neuron;experimental study;Gene Expression Profile;Genetic Transcription;Gliosis;Glutamates;Goals;Heterogeneity;Histologic;histological stains;Human;Impaired cognition;in vivo;inhibitory neuron;insight;Knock-in;Learning;Light;Mass Spectrum Analysis;Memory;Memory Loss;Modeling;Molecular;Morphology;mouse model;Mus;mutant;Nerve Degeneration;neural circuit;Neurofibrillary Tangles;Neuroimmune;Neurons;neuropathology;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Pattern;Peptides;Physiology;Play;Protein Isoforms;Proteins;Reaction;response;Role;secretase;Senile Plaques;single nucleus RNA-sequencing;Structure;Symptoms;Testing;trait;transcriptomics;Transgenic Mice;Transgenic Model;Transgenic Organisms;Visualization;Work

PROJECT_TITLE: Causes and consequences of differential APP processing in inhibitory and excitatory neurons

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BOISE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOISE STATE UNIVERSITY

ORG_STATE: ID

PHR: PROJECT NARRATIVE ─ OVERALL The goal of this proposed COBRE in Convergent Engineering and Biomolecular Science (CEBS) is to support the growth of multidisciplinary collaborative research at Boise State University and build research infrastructure through the creation and consolidation of research core facilities. The Center will also provide expertise, training, and mentoring in convergent research to help Research Project Leaders to become independent investigators. Together, these efforts will contribute to creation of a nationally recognized biomedical research center supporting the growing critical need in human healthcare for the development of medical devices and sensors.

PI_NAMEs: BROWNING, JIM  (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Accounting;Address;Advisory Committees;Annual Reports;Area;Award;base;Biology;Biomedical Engineering;Biomedical Research;Budgets;career development;Centers of Research Excellence;cohort;Collaborations;Collection;college;Communities;Data;Development;Devices;Doctor of Philosophy;editorial;Educational process of instructing;Educational workshop;Engineering;Ensure;Expenditure;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Extramural Activities;fabrication;Faculty;Feedback;Foundations;Funding;global health;Goals;Grant;Growth;Health;Healthcare;Human;Idaho;Industry;Infrastructure;infrastructure development;instrumentation;interest;Investments;Manuscripts;Medical Device;meetings;Mentors;Microfabrication;multidisciplinary;Office of Administrative Management;operation;Performance;Pilot Projects;Positioning Attribute;Problem Solving;Professional Organizations;Program Research Project Grants;Program Reviews;programs;Progress Reports;Publications;recruit;Reporting;Research;Research Activity;research and development;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;response;Schedule;Science;Scientist;sensor;Series;Services;Students;success;summer internship;symposium;System;Talents;Technical Expertise;Testing;Time;Training;Training Technics;Travel;undergraduate student;United States National Institutes of Health;Universities;voucher;Work;Writing

PROJECT_TITLE: Administrative Core


PI_NAMEs: DAVIS, PAUL HENRY (contact)

PROJECT_TERMS: Academia;Advanced Development;applied biomedical research;Area;Award;Biomedical Engineering;Biomedical Research;biomedical resource;Centers of Research Excellence;Charge;clinical translation;Collaborations;college;Computers;Contracts;Core Facility;cost;data acquisition;Data Collection;Development;Devices;Doctor of Philosophy;Educational workshop;electrical property;Engineering;engineering design;Equipment;fabrication;Faculty;Faculty Recruitment;Goals;Government;graduate student;Growth;Human Resources;Idaho;improved;Incentives;Industry;industry partner;Infrastructure;innovation;instrument;instrumentation;Investments;Maintenance;materials science;mechanical device;Medical Device;meetings;Microfabrication;operation;Optics;outreach;Performance;Personnel Management;Play;Printing;Privatization;Process;programs;prototype;Research;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;Role;Schedule;Science;sensor;Services;skill acquisition;Structure;Students;symposium;System;Technology;Testing;tool;Training;training opportunity;Universities;Validation;voucher;web site;Work

PROJECT_TITLE: FABRICATION, CHARACTERIZATION, AND TESTING CORE (FaCT CORE)


NIH_SPENDING_CATS: Arthritis;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Clinical Research;Osteoarthritis;Pain Research;Pediatric

PI_NAMEs: MANNEN, ERIN  (contact)

PROJECT_TERMS: 3-Dimensional;Agreement;Area;Avascular Necrosis of Femur Head;Biomechanics;Biometry;Birth;body position;Caregivers;Centers of Research Excellence;Clinical;Clinical Research;Collection;Complication;Computer Analysis;Computer Models;cost;Data;Data Collection;Data Reporting;Degenerative polyarthritis;design;Development;Devices;Disease;Dysplasia;early onset;Engineering;Equipment;fabrication;Failure;femur head;flexibility;foot;Frequencies;Future;Goals;Hip Joint;Hip Osteoarthritis;Hip region structure;Home;Home environment;Hour;Human;human subject;Image;improved;in vitro testing;in vivo;in vivo evaluation;Industry Collaboration;Infant;Knowledge;Laboratories;Life;Manikins;Manuals;manufacturing capabilities;Measurement;Measures;Mechanics;Medical;Medical Device;Methods;Monitor;Motion;Movement;Operative Surgical Procedures;Outcome;Pain;Patient Self-Report;Population;Positioning Attribute;pressure sensor;Recommendation;Research;research study;Risk;Science;sensor;Shapes;success;Supination;Testing;Textiles;Time;tool;Treatment Failure;Validation;Work

PROJECT_TITLE: Development and validation of a smart harness to study babies with developmental dysplasia of the hip


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention

PI_NAMEs: BROWN, TYLER  (contact)

PROJECT_TERMS: accurate diagnosis;Affect;Athletic;Biomechanics;bone;Bone Matrix;career;Communities;Computational algorithm;Cumulative Trauma Disorders;Data;Detection;Development;Diagnosis;diagnostic platform;Distal;Early Diagnosis;Early identification;Economics;electronic sensor;Emerging Technologies;Engineering;Etiology;Evaluation;experience;flexible electronics;Foundations;Fracture;fracture risk;Goals;Health;high risk population;Image;improved;Incidence;Individual;injured;Injury;injury prevention;innovation;Jogging;Joints;Knowledge;Lead;Leg;long bone;longitudinal analysis;Lower Extremity;Measures;mechanical load;Mental Health;Military Personnel;Modality;Modeling;Motor Activity;musculoskeletal injury;Outcome;Pain;Participant;Patients;Personal Satisfaction;Physical activity;physical conditioning;portability;Prevalence;Prevention;Principal Component Analysis;radiological imaging;radiologist;real time monitoring;Recording of previous events;Recovery;Recreation;Rehabilitation therapy;repaired;Reporting;Research;Research Personnel;Rest;Risk;Robotics;Running;Rupture;Science;Severities;Speed;Splint Device;Standardization;Statistical Models;Stress Fractures;stress reduction;Surface;Symptoms;System;Techniques;Technology;Testing;tibia;Tibial Fractures;Time;Torsion;Transducers;Ultrasonography;ultrasound;Vision;Walking;wearable device;Work

PROJECT_TITLE: Emerging Technologies for Early Detection of Distal Leg Stress Fracture.


ADMINISTERING_IC: NR

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CARBONDALE

ORG_NAME: POTENTIA ANALYTICS INC

ORG_STATE: IL

PHR: Project Narrative There is no patient-centric tool for recording, reviewing, and searching the medical conversations patients have with their healthcare providers, in spite of the fact that patients, on average, forget over 90% of the information communicated with them during office visits only after a few days. This project will provide patients with such a tool that will also support Q&A and further patient education to increase patient compliance and adherence to treatment plans, leverage the patients’ engagement in “shared decision making”, and provide “data mobility” for sharing with any “care partners”. Moreover, the novel representation of patients’ medical journey and other deep learning outcomes of the project will lay the groundwork for advancements in medical ontologies and future research on a variety of treatment plans.

PI_NAMEs: MARHAMATI, NINA  (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Address;Adult Children;Age;Aging;Algorithms;Appointment;Artificial Intelligence;artificial intelligence model;automated speech recognition;Caring;chatbot;Clinic;Collaborations;Communication;Complex;Comprehension;Computerized Medical Record;Consumption;Data;data integration;Databases;deep learning;deep learning model;design;Development;Diagnosis;Drug Prescriptions;Education;Elderly;empowerment;Enhancement Technology;Environment;experience;Family;Family member;flexibility;forgetting;Genetic Transcription;Goals;graph learning;Health;health care delivery;health organization;Health Personnel;health record;Healthcare;Hour;improved;information organization;innovation;Instruction;knowledge graph;Language;Lead;learning outcome;loved ones;Maintenance;Manuals;Medical;Medical Records;meetings;member;Mississippi;Modeling;Names;Natural Language Processing;novel;Office Visits;older adult;older patient;Ontology;Outcome;Parents;Patient Compliance;Patient Education;patient engagement;patient retention;Patients;Performance;Pharmaceutical Preparations;Phase;Play;poor health outcome;Populations at Risk;Production;prototype;Provider;Research Personnel;restoration;Role;Schedule;Secure;shared decision making;Specialist;Structure;Technology;technology platform;Telephone;Terminology;Testing;Text;Time;tool;Training;Transcript;transfer learning;Translations;treatment planning;Universities;usability;user-friendly;Visit;wasting

PROJECT_TITLE: MyDocSaid: Deep Learning for Patient-Centric Record, Summarization, and Analysis of Medical  Conversations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-J (10)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Congenital Heart Disease;Congenital Structural Anomalies;Diabetes;Genetics;Heart Disease;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Congenital heart defects (CHDs) are the most common class of birth defect worldwide, affecting 1% of all pregnancies and 4-5% of pregnancies affected by pregestational maternal diabetes mellitus (DM). Placental dysfunction is at the core of many adverse obstetric outcomes seen in pregnancies affected by either, and is thought to have a pivotal role in the development of fetal CHDs, particularly in the vasculopathic context of the DM state. The scientific aims of this proposed training plan could inform future biomarker-based diagnosis, in- utero therapy, and clinical risk management of pregnancies with maternal DM and/or fetal CHDs by comparing clinical risk associated with these pregnancies and determining the molecular correlates of placental dysfunction in each disease state.

PI_NAMEs: MAHADEVAN, ADITYA DEVIDAS (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: adverse outcome;Affect;angiogenesis;Biological Markers;biomarker identification;Blood Vessels;Cardiac;career;cell type;Characteristics;Child;Clinical;Clinical Pathology;clinical risk;Code;Congenital Abnormality;Congenital Heart Defects;cytotrophoblast;Databases;Defect;Deposition;Development;Diabetes Mellitus;diabetic;Diabetic mother;Diagnosis;Diagnostic;Discipline of obstetrics;Disease;Doctor of Philosophy;Early Diagnosis;early pregnancy;Endothelium;Epithelium;Etiology;fetal;Fetal Development;Fetal Growth Retardation;Fibrin;Formalin;Functional disorder;Future;General Population;Genes;Genetic Transcription;Goals;health data;health record;Heart;hemodynamics;High-Throughput RNA Sequencing;Histologic;Human;Hyperglycemia;Hypoxia;Immunohistochemistry;improved;in utero;Incidence;Infant;Infant Mortality;Inflammatory;Institution;Intervention;Investigation;Link;malformation;maternal diabetes;maternal morbidity;Mediating;Mediator;Mesenchymal;Methodology;Molecular;Morbidity - disease rate;Morphology;mortality;Mothers;multimodality;Neonatal;Neonatal Hypoglycemia;neonatal morbidity;Neuropilin-1;novel;NRP1 gene;obstetric outcomes;Ontology;Operative Surgical Procedures;Organ;Outcome;Paraffin Embedding;Pathology;Pathway interactions;Pattern;Perinatal;Perinatal Care;perinatal complications;Perinatal mortality demographics;perinatal outcomes;Phenotype;Physiology;Placenta;placental morphology;Placentation;Play;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy in Diabetics;Premature Birth;prenatal;prenatal therapy;Preparation;prevent;Prevention;Principal Investigator;Process;prognostic;protein expression;Proteins;Relative Risks;Research Proposals;Resolution;Risk;Risk Assessment;Risk Management;Role;Scientist;Serum;Signal Pathway;Signal Transduction;Spontaneous abortion;Structure;Supplementation;Testing;Thrombosis;Tissue Embedding;Tissues;Training;translational physician;Translations;Umbilical vein;Umbilicus;vascular abnormality;Vascular Diseases;Vascular Endothelium;Villous;Vocational Education;Western Blotting

PROJECT_TITLE: Clinical, Histological, and Transcriptional Associations Between the Diabetic Placenta and Fetal Congenital Heart Defects

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-L (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Frontotemporal Dementia (FTD) is a major cause of early onset dementia, and mutations in the progranulin gene causes FTD with TDP-43 pathology. We will utilize a mouse model to evaluate TDP-43 pathology and function in the context of progranulin insufficiency. Using these mice, we will investigate the role of TDP-43 dysfunction in a key brain region that influences social dominance behavior.

PI_NAMEs: COOK, ANNA K (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Affect;Age;Age Months;age related;Automobile Driving;axon growth;Behavior;Behavioral;Behavioral Assay;Biochemical;Biological Assay;Brain region;career;Clinic;Collaborations;Competence;conditioned fear;Cytoplasm;Data;Dementia;Dendritic Spines;density;Development;Disease;Dyes;early onset;Environment;Exhibits;experience;experimental study;Foundations;Fractionation;frontal lobe;Frontotemporal Dementia;Functional disorder;Future;Genetic;Genetic Models;Gliosis;Glycoproteins;Goals;Heterozygote;Homeostasis;Human;Immunohistochemistry;Impairment;Impulsivity;Inflammation;insight;Investigation;Language;language impairment;large datasets;Link;loss of function mutation;lucifer yellow;Measures;Medial;Modeling;Morphology;motor deficit;mouse model;Mus;Mutation;Nerve Degeneration;Neurobiology;neuroimaging;neuronal survival;Neurons;Nuclear;Nuclear RNA;Oral;overexpression;Parents;Pathogenesis;Pathogenicity;Pathology;Patients;PGRN gene;Phenotype;Physicians;postnatal;Prefrontal Cortex;protein TDP-43;Proteins;Research;responsible research conduct;RNA Splicing;RNA-Binding Proteins;Role;Scientist;small hairpin RNA;social;social deficits;Social Dominance;social influence;Solid;Symptoms;TDP-43 aggregation;Techniques;Testing;Therapeutic;Time;timeline;Training;Transcript;Transgenic Mice;Transgenic Organisms;translational approach;Tube;Vertebral column;Withdrawal;Writing

PROJECT_TITLE: Interactions between progranulin insufficiency and TDP-43

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-N (20)]


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Cerebrovascular;Clinical Research;Immunotherapy;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative Arteries have natural protection against autoimmune disease, but in the case of giant cell arteritis (GCA) this protection is lost, the patients develop arterial inflammation, and are threatened by blindness, stroke and aortic aneurysm. This project examines defects in the immune system of GCA patients, so-called immune checkpoints, which cause the expansion of disease-inducing immune cells and seeks to define common targets in anti-cancer immunity and in vascular inflammation.

PI_NAMEs: WEYAND, CORNELIA M. (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Aneurysm;anti-cancer;Antibodies;Antigen-Presenting Cells;Antigens;antiviral immunity;Aorta;Aortic Aneurysm;Aortic Arch Syndromes;Aortic Diseases;Aortitis;Arteries;Autoimmune;Autoimmune Diseases;Autoimmunity;Automobile Driving;Award;Biological Models;Biopsy;Blindness;Blood Vessels;CD4 Positive T Lymphocytes;Cell membrane;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chronic stress;Cohort Studies;Containment;cytokine;Data;Defect;Diagnosis;Disease;Dissection;druggable target;Effector Cell;effector T cell;Elasticity;Endoplasmic Reticulum;endoplasmic reticulum stress;experimental study;Failure;gain of function;Granulomatous;Human;IL9 gene;Immune;immune checkpoint;Immune response;Immune system;Immune Tolerance;Immunity;In Vitro;in vivo;in vivo Model;Infiltration;Inflammation;Inflammatory;Interleukin-9;Invaded;Lead;Lesion;Licensing;Ligands;Link;loss of function;Macrophage;Maps;Mediating;Membrane;Modeling;Molecular;Molecular Abnormality;monocyte;mouse model;NOTCH1 gene;NOTCH4 gene;Pathogenicity;Pathway interactions;patient retention;Patients;PD-1/PD-L1;peripheral blood;Phenotype;poliovirus receptor;Population;Process;Production;programmed cell death ligand 1;programmed cell death protein 1;Proteins;Proteome;prototype;Recombinants;Regulatory Pathway;Regulatory T-Lymphocyte;Resistance;Resources;restraint;Self Tolerance;Signal Transduction;Specific qualifier value;Stroke;Surface;Syndrome;T cell differentiation;T-Cell Activation;T-Lymphocyte;Temporal Arteritis;Testing;Therapeutic;Therapeutic immunosuppression;Tissues;trafficking;transcriptome;Tumor Immunity;vascular inflammation;Vasculitis;Veno-Occlusive Disease;Work

PROJECT_TITLE: T Cell Immunity in Giant Cell Arteritis

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Infant Mortality;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Women and infants face substantial risks of illness and death during pregnancy and after birth. Group antenatal care is an innovative model that has effectively addressed many of these mental and physical health challenges, both in the US and globally. The purpose of this study is to understand how community building, or how the experience of being in a group intervention during pregnancy, contributes to mental and physical outcomes.

PI_NAMEs: BATCHELDER, ANNE  (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Address;Africa South of the Sahara;antenatal;antenatal care;Birth;care providers;Caring;Cessation of life;Child;Child health care;Clinical;Communication;Communities;community building;contextual factors;Control Groups;Data;Data Analyses;Data Collection;Decision Making;effective intervention;Effectiveness;effectiveness trial;empowerment;evidence base;experience;Face;Family;Fostering;Funding;Gestational Age;Ghana;Goals;group intervention;Group Meetings;hands-on learning;Health;Health Personnel;Health Promotion;Health system;Healthcare;Improve Access;improved;Individual;Infant;Infant Mortality;innovation;insight;Intervention;Interview;Kenya;Leadership;Link;Live Birth;Low Birth Weight Infant;Low income;Malawi;Maternal and Child Health;Maternal Mortality;maternal outcome;Measures;Mediating;Mental Health;Methods;Midwife;Modeling;National Institute of Nursing Research;Neonatal Mortality;Nigeria;Outcome;Parents;Participant;Partner Communications;peer;perinatal period;person centered;Personal Satisfaction;Persons;physical conditioning;Pilot Projects;Play;Policies;Population;Postpartum Period;Postpartum Women;Pregnancy;pregnant;Pregnant Women;Prenatal care;Process;programs;Provider;Psyche structure;psychological distress;Quality of Care;Randomized;Recommendation;Research;Research Infrastructure;Risk;Role;Safety;satisfaction;secondary analysis;Self Efficacy;Services;skills;Socialization;success;System;Time;Training;treatment as usual;Visit;volunteer;Woman;Women's Group;World Health Organization

PROJECT_TITLE: Community Building in Group Antenatal Care in Malawi

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (87)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative  Non-typeable Haemophilus influenzae is a bacterial pathogen that causes lung and ear infections and severe exacerbations in individuals with chronic obstructive pulmonary disease. This project will uncover the post-translational modifications and function of a recently identified virulence factor that plays a significant role in human cell invasion during infection. Understanding the molecular details by which this virulence factor functions will provide opportunities for development of new therapeutics.

PI_NAMEs: MANLEY, OLIVIA M (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Address;Adult;Affect;American;Amino Acids;Anabolism;Antibiotic Resistance;Bacteria;Binding;Biochemical;Biological Assay;biophysical techniques;Biophysics;Biosynthetic Proteins;Cause of Death;Cells;Chronic;Chronic Obstructive Pulmonary Disease;cofactor;combinatorial;Complex;Copper;Cysteine;Data;Development;ear infection;Electron Spin Resonance Spectroscopy;Epithelial Cells;Epitopes;Escherichia coli;Family;Foundations;Gene Cluster;Genes;Genetic;Genome;Goals;Gram-Negative Bacteria;Haemophilus influenza virulence;Haemophilus influenzae;Hemophilus influenza infection;Human;Hypothetical Protein;In Vitro;in vivo;Individual;Infection;Inflammatory;influenza infection;influenza virus strain;insight;Interferometry;Invaded;Investigation;Iron;Knock-out;Ligands;Lung Diseases;Lung infections;Mass Spectrum Analysis;member;Metals;Methylococcaceae;Mining;Modification;Molecular;Molecular Structure;Nature;new therapeutic target;Nontypable Haemophilus influenza;novel therapeutic intervention;novel therapeutics;Operon;Optics;Organism;Outcome;Oxazolone;oxidation;pathogen;Pathogenesis;pathogenic bacteria;peptide natural products;Peptides;Play;Pneumonia;Positioning Attribute;Post-Translational Protein Processing;Property;protein complex;Protein Family;Proteins;Proteolysis;Proteomics;Reaction;reconstitution;Research Proposals;Ribosomes;Role;Spectrometry, Mass, Electrospray Ionization;Structure;targeted treatment;Thioamides;Virulence;Virulence Factors;Work;X-Ray Crystallography

PROJECT_TITLE: Uncovering the mechanism of virulence factor maturation in Haemophilus influenzae

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Approximately 45% of pregnancies are unintended, demonstrating an unmet need for comprehensive contraception. This project is relevant to public health because it aims to generate new small molecule hits and insights for a highly validated contraceptive target, the sperm-specific CatSper calcium channel, using an innovative functional expression system that allows for high-throughput cell-based screening and mechanism of action studies. The proposed research is relevant to the NIH’s mission because it will contribute to the development of a new class of contraceptives and the improvement of reproductive health in men and women.

PI_NAMEs: CHUNG, JEAN-JU LUCIA (contact)

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: Adsorption;Antibodies;Binding;Binding Sites;Biological Assay;biophysical analysis;Biophysics;birth control;Calcium;Calcium Channel;CatSper;Cell membrane;Cells;Chemicals;Chimera organism;Computer Assisted;condoms;Contraceptive Agents;Contraceptive Availability;Contraceptive methods;contraceptive target;counterscreen;design;Development;drug development;Drug Kinetics;egg;Electrophysiology (science);Engineering;Evolution;Excretory function;Fertility;Fertilization;Fertilization in Vitro;fluorescence imaging;Foundations;Free Energy;Generations;Genes;Goals;Hamsters;high throughput screening;Human;Image;improved;in silico;In Vitro;Infertility;inhibitor;innovation;insight;Knowledge;Lead;Libraries;Life;male fertility;Measures;meetings;Meiosis;men;Metabolism;Methods;Mission;Molecular;molecular dynamics;Motility;Movement;Mus;Mutation;novel;patch clamp;Penetration;Pharmaceutical Preparations;Phase;prevent;Property;Public Health;Reader;reconstitution;Reporting;Reproductive Health;Research;reversible contraceptive;screening;Seminal fluid;Series;side effect;small molecule;small molecule libraries;Specificity;Sperm Capacitation;sperm cell;sperm function;Spermatocytes;Structure;Structure-Activity Relationship;Surface;System;T-Type Calcium Channels;Technology;Testing;tool;unintended pregnancy;United States National Institutes of Health;Vasectomy;virtual screening;Woman;Work;Zinc Compounds;zygote

PROJECT_TITLE: Engineering and targeting the sperm-specific calcium channel CatSper for contraception

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-Z (55)]


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE The exonuclease TREX1 plays a key role in antitumor immune surveillance and autoinflammatory disease by digesting cytosolic DNA to suppress innate immunity. This project will characterize novel structural features in TREX1 to investigate how TREX1 accesses DNA substrates in cells and how TREX1 ectopic localization in the nucleus can induce disease. Successful completion of the project will thus establish structure-function relationships of novel TREX1 elements, as well as elucidate the molecular etiology of TREX1 mutations in cancer and autoinflammatory disease.

PI_NAMEs: SHIM, ABRAHAM  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Aldehydes;Amino Acid Sequence;Autoimmune Diseases;autoinflammatory diseases;Autophagocytosis;Base Excision Repairs;Behavior;Binding;Biological Assay;C-terminal;cancer therapy;Cell Nucleus;Cells;ChIP-seq;Chromatin;Complex;Coupled;Data;Digestion;Disease;DNA;DNA Damage;DNA lesion;DNA Repair;DNA Repair Pathway;Elements;endonuclease;Ensure;Enzyme-Linked Immunosorbent Assay;established cell line;Etiology;exodeoxyribonuclease;Exonuclease;Frameshift Mutation;Freedom;Frequencies;Gene Expression;Genes;Genetic Transcription;Genomic Instability;Goals;Human;human disease;Image;Immune;immune activation;immunogenic;Immunologic Surveillance;immunoregulation;Immunosuppression;In Vitro;Inflammatory;innate immune mechanisms;Innate Immune Response;insight;Interferon Type I;Interferons;intermolecular interaction;Knockout Mice;Label;Lead;Length;Link;Lipids;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mitotic;Molecular;Molecular Target;mutant;Mutation;Natural Immunity;novel;Nuclear;nuclease;null mutation;overexpression;paralogous gene;pathogen;Pathway interactions;Phenotype;Phosphorylation;Play;Point Mutation;polyproline;prevent;Proteins;pseudotoxoplasmosis syndrome;recruit;Regulation;Regulatory Pathway;response;retinal vasculopathy with cerebral leukodystrophy;Risk;Role;sensor;Signal Transduction;Site;Source;Stimulator of Interferon Genes;Structure;Structure-Activity Relationship;Testing;Three Prime Repair Exonuclease 1;transcription factor;transcriptome sequencing;Transgenes;Transmembrane Domain;TREX1 gene;TREX2 gene;tumor;Tumor Escape;Tumor Immunity;Viral;Western Blotting

PROJECT_TITLE: Mechanisms of cytosolic DNA degradation by TREX1 in cancer and autoimmune disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative High-gradient diffusion MRI holds great promise for capturing the earliest microscopic gray matter abnormalities present in Alzheimer’s disease before their overt manifestation on conventional MRI. In this project, we will use the sensitivity of high-gradient diffusion MRI to map alterations in cellular microstructure in patients with mild cognitive impairment and Alzheimer’s disease and provide validated diffusion MRI measures of cortical and subcortical gray matter degeneration.

PI_NAMEs: HUANG, SUSIE YI (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta accumulation;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapy;Amyloid;Anisotropy;Area;Autopsy;Axon;biomarker validation;Brain;BRAIN initiative;Brain Mapping;brain tissue;Cell Density;Cells;Cellular Morphology;Clinical Research;Cognitive;cohort;connectome;cortex mapping;Data;Dementia;density;Deposition;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;Event;Evolution;Future;General Hospitals;Goals;gray matter;hippocampal atrophy;Histopathology;Human;Image;imaging biomarker;in vivo;Individual;insight;life span;Longitudinal Studies;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Massachusetts;Measures;medial temporal lobe;Microscopic;mild cognitive impairment;Morphology;neocortical;Nerve Degeneration;Neurites;Neurofibrillary Tangles;Neurologic;neuron loss;neuroprotection;next generation;older adult;Older Population;Pathologic;Pathology;Patients;Performance;Positron-Emission Tomography;Predictive Value;Protocols documentation;Research;Risk;Senile Plaques;Specificity;Specimen;structural imaging;Structure;success;Swelling;Symptoms;Synapses;System;tau Proteins;Thinness;tool;Translating;Translations;uptake;Validation;Variant;Varicosity;Virulence Factors;white matter;white matter change;Work

PROJECT_TITLE: Developing a validated biomarker of cortical neurodegeneration in Alzheimer's disease using high-gradient diffusion MRI

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Bacteria programmed to make anti-cancer drugs will grow inside tumors but not normal organs, which means they can be used to specifically deliver drugs to tumors and metastases and reduce side effects. However, bacteria don’t colonize human tumors very well, and we don’t really understand why. We will use many strains of bacteria with mutations in different genes to see which genes affect colonization of tumors, which will let us make anti-cancer bacteria that are even more specific to tumors.

PI_NAMEs: CHEN, NOAH  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Affect;anti-cancer;Antineoplastic Agents;Award;Bacteria;Bacterial Genes;Bacterial Infections;Bar Codes;Blood Circulation;cancer immunotherapy;cancer therapy;Clinical;Communities;comparative;Data;Discipline;Dose;early phase clinical trial;Environment;Escherichia;Escherichia coli;experimental study;Fellowship;Genes;Genetic Determinism;Homing;Human;Immune;Immunologist;improved;in vitro Assay;in vivo;Infection;Injections;intravenous administration;intravenous injection;Knock-out;Libraries;Literature;Malignant Neoplasms;Mediating;Medicine;Microbial Biofilms;migration;Modeling;mouse model;Mutation;Neoplasm Metastasis;Organ;Pathway interactions;Patients;Pharmaceutical Preparations;phosphoric diester hydrolase;Physicians;Process;Production;promoter;Property;Research;Research Personnel;response;Role;Salmonella;scale up;Scientist;side effect;Signal Induction;Site;skills;Specificity;STING agonists;Therapeutic;Training;tumor;Tumor Immunity;tumor specificity;Tumor Tissue;Work

PROJECT_TITLE: Improving bacterial cancer therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-Z (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD), a leading cause of morbidity and mortality in older adults, causes significant cognitive impairment, but current therapeutic efforts have not provided clinically meaningful improvements in cognition. The proposed research will use plasma proteomic methodologies to identify novel plasma biomarkers predictive of early cognitive decline in older adults without clinical dementia or stroke. Findings from this proposal will aid in identification of novel therapeutic targets for prevention and treatment of cognitive decline and AD.

PI_NAMEs: ADEGBOYE, HAILEY  (contact)

PROJECT_TERMS: Academic Medical Centers;Acute;ADAMTS;Adult;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;Autopsy;Blood Vessels;Cardiovascular system;career;Clinical;Cognition;Cognitive;Cognitive aging;cohort;Country;Data;Dementia;differential expression;Disease Progression;early detection biomarkers;executive function;Exposure to;Fellowship;follow-up;Functional disorder;Future;Geriatrics;human old age (65+);Impaired cognition;improved;Individual;Inflammatory;information processing;innovation;insight;Institution;interest;ischemic injury;Knowledge;Link;Literature;Medicine;Memory;Mentorship;Metalloproteases;Methodology;Methods;middle age;mild cognitive impairment;Modeling;Morbidity - disease rate;mortality;Neuropsychology;Neurosciences;new therapeutic target;novel;novel marker;older adult;Outcome;Participant;Pathology;Pathway interactions;Physicians;Plasma;Plasma Proteins;Population;predictive marker;prevent;Prevention;Prevention approach;Process;processing speed;Protein Analysis;Proteins;Proteomics;Recombinants;Research;Resources;Risk;Role;Scientist;Site;skills;Stroke;Technology;Therapeutic;Thrombosis;Training;training opportunity;vascular contributions;Vascular Diseases;vascular risk factor;Work

PROJECT_TITLE: Utilizing Plasma Proteomics to Identify Novel Biomarkers of Cognitive Aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Substance Misuse

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Narrative Under most circumstances, people's brains derive nearly all their energy needs from the sugar glucose, but when people drink alcohol, their bodies convert most of the alcohol to acetate, which over time and quantity can lead the body to adapt to the acetate. Acetate is also a key source to make a stress-related chemical called cortisol, which has effects on behavior and even the size of key brain areas. We will measure possible associations between drinking style (light, binging, or dependent) to see if the ability to consume that acetate is related to cortisol, shrinkage of certain regions of the brain, and behavior, which raises possibilities of certain nutritional supplements to help people get through detoxification.

PI_NAMEs: MASON, GRAEME F. (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Acetates;Acids;Affect;Alcohol abuse;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol misuse;alcohol seeking behavior;Alcoholic beverage heavy drinker;Alcohols;Amygdaloid structure;Anatomy;Anti-Inflammatory Agents;Area;Astrocytes;Behavior;binge drinker;biological adaptation to stress;Blood;Blood specimen;Brain;Brain Mapping;Brain region;brain volume;Cerebrum;Chemicals;Chronic;Clinical;comorbidity;Consumption;craving;Data;Dependence;Deuterium;Diabetes Mellitus;dietary supplements;Dose;drinking;Drops;Drug Metabolic Detoxication;Electric Stimulation;Energy Metabolism;Ethanol;Exposure to;Generations;global health;Glucose;Heavy Drinking;Histone Acetylation;Hydrocortisone;Hypoglycemia;hypothalamic-pituitary-adrenal axis;Impairment;in vivo;Individual;Inflammatory;Infusion procedures;innovation;insulin secretion;Ketone Bodies;Label;Lead;Light;Link;Liver;Maps;Measures;metabolic imaging;metabolic rate;Methods;Motor Cortex;Negative Reinforcements;Neurons;Neurosecretory Systems;neurotoxic;novel;nutrient deprivation;Outcome;oxidation;Persons;Positive Reinforcements;Positron-Emission Tomography;Prefrontal Cortex;Recovery;recruit;Reporting;Research;response;Rewards;sobriety;Source;Starvation;Stress;Structure;sugar;Techniques;Testing;therapy design;Time;trait;Vascular blood supply;Withdrawal Symptom

PROJECT_TITLE: Drinking, Brain Acetate, and Stress

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Prevention;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Per- and polyfluoroalkyl substances (PFAS) (sometimes called “forever chemicals”) are a group of synthetic and persistent chemicals detected globally due to their transportability, chemical stability, and widespread use in industrial processes and consumer products. PFAS appear to cause negative health outcomes, including dyslipidemia (an imbalance of blood lipids, such as cholesterol), an important risk factor for heart disease. Volunteer firefighters have an increased risk of on-duty cardiac-related mortality, however, their exposures to PFAS and the relationship with dyslipidemia are not well understood and will be examined by this project.

PI_NAMEs: LUBINA, KATHERINE ALEXIS (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: absorption;Address;Affect;anthropogenesis;aqueous;Blood;blood lipid;Blood specimen;Cardiac;Cardiovascular Diseases;career;Cessation of life;Characteristics;chemical stability;Chemicals;Cholesterol;clinical translation;clinically relevant;cohort;Cohort Studies;combustion product;Communities;community-level factor;consumer product;contaminated drinking water;contaminated water;Data;Dermal;Dyslipidemias;Enrollment;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Impact;Epidemiologic Methods;Epidemiologist;Event;evidence base;experience;exposure route;Exposure to;Fellowship;Film;fire fighter;first responder;Food;Funding;geographic difference;Goals;Grant;Health;Heart Diseases;Hobbies;House Dust;improved;Industrialization;Ingestion;Inhalation;Intervention;Knowledge;LDL Cholesterol Lipoproteins;Lipids;Literature;Low-Density Lipoproteins;Malignant Neoplasms;Measures;member;Mentors;Modeling;mortality;Myocardial Ischemia;novel;Occupational;Occupational Exposure;Occupations;Outcome;Participant;Pathway interactions;Persons;Play;pollutant;Poly-fluoroalkyl substances;Population;prevent;Prevention;Process;Protective Clothing;Public Health;Recreation;Reporting;Research;Risk;Risk Factors;Role;Route;rural area;Safety;Science;Scientific Advances and Accomplishments;Seroprevalences;Serum;Site;sociodemographics;Source;suburb;sudden cardiac death;Surveys;Toxicology;Training;volunteer;Work

PROJECT_TITLE: Per- and polyfluoroalkyl substances (PFAS) occurrence and associations with dyslipidemia among community-based U.S. volunteer firefighters


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative Malaria remains one of the most significant and impactful global health diseases today. We will study essential regulatory features of the Plasmodium parasite as creates sporozoite stage parasites in oocysts found on the mosquito midgut. Specifically, this proposed work will focus on the development and composition of the basal complex during the early, mid, and late stages of sporogony.

PI_NAMEs: DVORIN, JEFFREY D;LINDNER, SCOTT E (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: 3-Dimensional;Anopheles Genus;asexual;Attention;Binding;Biogenesis;Biological;Biological Process;Blood;Cell membrane;Cell Nucleus;Cell Shape;Cells;Cessation of life;Complex;Culicidae;Cytokinesis;Data;Daughter;daughter cell;Development;Disease;Erythrocytes;Excision;experimental study;global health;Hepatocyte;Human;Image;In Situ;Infection;Ions;Knowledge;Life Cycle Stages;Liver;Malaria;Mediating;member;Membrane;Microscopy;Midgut;Molecular;Mothers;Oocysts;Organelles;Parasites;Plasmodium;Plasmodium yoelii;Process;Production;Proteins;Proteomics;Public Health;Resolution;Role;Sampling;Scanning Electron Microscopy;Shapes;Sporozoites;Structure;three-dimensional visualization;transmission process;vector mosquito;Work

PROJECT_TITLE: Development and Composition of the Basal Complex During Plasmodium Sporogony

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-M (02)]


NIH_SPENDING_CATS: Asthma;Climate-Related Exposures and Conditions;Clinical Research;Health Effects of Indoor Air Pollution;Lung;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Environmental exposure to traffic related air pollution is a risk factor for wheezing, asthma and other respiratory diseases and particulate matter can evoke specific immune responses that can adversely impact human health. In this proposal, we are determining if traffic emitted ultrafine particles disrupt natural pro-resolving mediators and resolution mechanisms for inflammation and lead to increased susceptibility for chronic inflammatory disease as well as increased susceptibility to allergen induced asthma.

PI_NAMEs: DEMOKRITOU, PHILIP ;LEVY, BRUCE D (contact);SERHAN, CHARLES NICHOLAS

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Academy;Acute;Agonist;Air;Airway Disease;airway epithelium;airway inflammation;Allergens;Allergic;ambient air pollution;American;Anabolism;Anti-Inflammatory Agents;antimicrobial;Area;Asthma;asthma exacerbation;Biological Assay;Birth;Boston;CD59 Antigen;cell type;Cells;cellular transduction;Characteristics;Chemistry;Chest;Child;Chronic;chronic inflammatory disease;Chronic lung disease;climate change;cohort;Collaborations;Computational Biology;Dendritic Cells;Deposition;Diameter;Disease;environmental agent;Environmental Exposure;Environmental Health;Environmental Impact;Environmental Medicine;environmental particulate;epidemiologic data;Epithelial Cells;Experimental Models;exposed human population;Exposure to;Family;fighting;Flow Cytometry;Goals;Health;Homeostasis;House Dust Mite Allergens;Household;Human;Hypersensitivity;Immune;Immune response;Immunology;Immunophenotyping;In Vitro;in vivo;Inflammation;Inflammatory Response;Inhalation;Inhalation Exposure;innovation;instrumentation;Interruption;Kinetics;Laboratories;Link;lipidomics;Lipoxins;Lung;Macrophage;Mediator;meter;Modeling;Molecular;nanocarrier;Nature;novel;novel therapeutic intervention;particle;particle exposure;Particle Size;Particulate Matter;Pathway interactions;Phase;Pollution;Predisposition;Prevalence;Process;Production;programs;Property;Publishing;Pulmonary Inflammation;Pyroglyphidae;receptor;Receptor Signaling;Reporter;Research;Resolution;respiratory;Respiratory Disease;respiratory health;response;Risk;Risk Factors;Sampling;Scientist;Seasons;Severities;Societies;Source;Surface;System;Testing;Therapeutic;Time;Tissues;traffic-related air pollution;transcriptome;transcriptome sequencing;ultrafine particle;Urbanization;Variant;Wheezing;Widespread Disease;Wildfire

PROJECT_TITLE: Traffic-Related Ultrafine Particles Disrupt The Resolution Of Lung Inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-E (03)]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Microbiome

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the discovery of mechanisms by which microorganisms colonize the gastrointestinal tract is expected to lead to increased understanding and new treatments for human inflammatory and metabolic diseases. The proposed research is therefore relevant to the part of the NIH’s mission that pertains to developing fundamental new knowledge that will enhance health and reduce the burden of illness.

PI_NAMEs: RASSADKINA, YELIZAVETA  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Address;Adult;Affect;Amines;Anaerobic Bacteria;Antibodies;Binding;Binding Proteins;Biological Assay;Birth;burden of illness;Carrier Proteins;Cells;ChIP-seq;Code;Complex;Coupled;Data;Development;Disease;DNA-Binding Proteins;Ecosystem;Environment;experimental study;fatty acid-transport protein;Fatty Acids;fitness;fluorescence imaging;Gastrointestinal tract structure;gene function;gene product;gene repression;Genes;genetic analysis;genetic manipulation;Genetic Transcription;Genome;germ free condition;Germ-Free;Goals;gut bacteria;gut colonization;gut microbiome;gut microbiota;Health;Health Promotion;Human;Immobilization;Immunohistochemistry;Immunoprecipitation;improved;In Vitro;in vivo;Infiltration;Inflammatory;Inflammatory Bowel Diseases;insight;Intestines;Invaded;Knock-out;Knowledge;Label;Large Intestine;Libraries;Link;Lipid Binding;lipid transport;Lipids;Location;Mammals;Maps;Mass Spectrum Analysis;Mediating;member;Metabolic Diseases;metabolomics;Microbe;microbial;microbial community;microbiome composition;microbiota;microorganism;Mission;Molecular;Mus;mutant;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Operon;Outcome;Outcome Study;Peptide Signal Sequences;Phospholipids;Physiological;Physiology;Play;Polycystic Ovary Syndrome;Probiotics;protein function;Protein Secretion;protein transport;Proteins;Public Health;Research;Role;Small Intestines;Testing;Tissue Sample;tool;Transcription Repressor;transcriptome sequencing;United States National Institutes of Health;Western Blotting;Work

PROJECT_TITLE: Genetic analysis of competition dependent fitness determinants in the human gut bacterium Phocaeicola vulgatus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health since it focuses on evaluating potential, modifiable factors (distance to care and residential environment) for childhood cancer survivors to improve the quality of survivorship care opportunities and later life health outcomes. Reducing barriers to survivorship care opportunities may improve the quality of life and life expectancy for childhood cancer survivors. Thus, the proposed research is relevant to NCIs mission to support cancer research to advance scientific knowledge and help all people live longer, healthier lives.

PI_NAMEs: THOMAS, AMANDA S (contact)

PROJECT_TERMS: active method;Address;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adult;Affect;Aftercare;Age;aged;aging population;anti-cancer research;Area;Automobile Driving;cancer epidemiology;Cancer Patient;Cancer Research Network;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer therapy;cancer type;care delivery;care outcomes;care providers;Caring;Characteristics;Child;childhood cancer survivor;Children's Cancer Group;Chronic;Climate;Clinic;Clinic Visits;cohort;Communication;Complex;Continuity of Patient Care;Cox Proportional Hazards Models;Data;Data Set;Data Sources;density;Diagnosis;Diagnostic;Directories;Disparity population;doctoral student;Environment;Epidemiology;Equity;ethnic difference;Ethnic Origin;experience;Fellowship;Frequencies;Funding;Geography;Grant;Health;health care delivery;health care disparity;health disparity;health equity;Health Sciences;Health Services Accessibility;Healthcare;healthcare community;Healthcare Systems;Heterogeneity;high risk;improved;improved outcome;Incidence;Individual;Institution;Knowledge;Late Effects;late life;Life;Life Cycle Stages;Life Expectancy;Literature;Location;Longevity;low socioeconomic status;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mediation;Mentors;Minnesota;Minority;Mission;Morbidity - disease rate;mortality;Movement;National Institute of Child Health and Human Development;Outcome;Patients;Pediatric Oncology Group;Persons;Population;population health;pre-doctoral;Protocols documentation;Provider;Psyche structure;psychosocial;psychosocial wellbeing;Public Health;Quality of life;Race;racial difference;Recording of previous events;Research;Research Design;Research Personnel;residence;Risk;Role;rural area;rurality;Scientific Advances and Accomplishments;secondary analysis;Services;sex;skills;Socioeconomic Status;Survivors;survivorship;Training;Training Programs;Transportation;Travel;Universities;Vulnerable Populations;Work;Writing

PROJECT_TITLE: Living Beyond Cancer: How Distance Impacts Childhood Cancer Survivorship Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative Mitochondrial-selective autophagy (mitophagy) is an essential cellular process needed to promote cell survival, but the genes that play a role in this process are not well understood. I am studying a novel regulator of mitophagy at the mitochondrial surface that physically interacts with lipid transport protein VPS13D, a gene implicated in age-associated movement disorders that regulates mitochondrial clearance. Studying this process will benefit our overall understanding of mitophagy, and provide novel insight into therapeutics to combat defective mitophagy diseases like Parkinson’s disease.

PI_NAMEs: RESTREPO, LUCAS JOHN (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Affect;age related;Aging;Antibodies;Area;Ataxia;Autophagocytosis;Autophagosome;Biochemical Pathway;Carrier Proteins;Cell Physiology;Cell Survival;Cells;combat;comparison control;CRISPR/Cas technology;Defect;Development;Disease;Drosophila genus;early onset;Endoplasmic Reticulum;Exhibits;Failure;Family;fly;Genes;Genetic;Health;Homologous Gene;Human;immunocytochemistry;insight;knock-down;knockout gene;Lead;lipid biosynthesis;lipid transfer protein;lipid transport;loss of function;Lysosomes;Mediator;member;Membrane Proteins;Metabolic;Metabolism;metabolomics;Midgut;Mitochondria;mitochondrial autophagy;Mitochondrial Diseases;mitochondrial membrane;Morphology;Motor Neuron Disease;Movement Disorders;mutant;Mutation;novel;Organelles;Parkin;Parkinson Disease;Pathway interactions;Phenocopy;Phenotype;PINK1 gene;Play;prevent;Process;Proteins;Proteomics;Quality Control;RNA Interference;RNA interference screen;Role;Site;solute;Spastic Paraplegia;spasticity;Surface;targeted treatment;Therapeutic;Transmission Electron Microscopy;Vacuolar Protein Sorting;Vesicle

PROJECT_TITLE: Identification of a Putative Mitochondrial Solute Carrier that Regulates Mitophagy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ORG_CITY: CAMBRIDGE

ORG_NAME: PEARL BIO, INC.

PHR: PROJECT NARRATIVE Despite their potential, protein biologics, and in particular, cytokines, often exhibit poor “peak-and-valley” pharmacokinetic profiles, rapid degradation, systemic immune activation (due to their on-target, off-tumor effect), resulting in dose-limiting toxicities, impaired efficacy and poor patient compliance. To address these defining challenges, and advance biotherapeutic development beyond the state-of-the-art, Pearl Bio has developed a proprietary technology platform to enable precise, multi-site functionalization of next-generation biologics to catalyze new protein drug design capabilities. In this project we will generate a set of functionalized IL-15 therapeutic candidates that are (a) lipidated to tune half-life and (b) endowed with novel tumor targeting modalities for enhanced binding specificity.

PI_NAMEs: CHATTOPADHYAY, SOUVIK  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Albumins;Amino Acids;Animals;antibody engineering;antigen binding;Binding;Biological;Biological Assay;Biological Products;Biological Response Modifier Therapy;Biology;Biomedical Engineering;Cell Culture Techniques;Chemicals;Chemistry;Circulation;Clinic;Clinical;Clinical Trials;Code;cytokine;design;Development;Disease;Dose;Dose Limiting;Drug Design;Drug Kinetics;Endowment;Engineering;Exhibits;Failure;Fatty Acids;Genomics;Half-Life;Hepatitis C;Homing;immune activation;immune modulating agents;immunogenic;immunogenicity;Immunooncology;Impairment;improved;In Vitro;in vitro testing;in vivo;Infection;Interleukin-10;Interleukin-15;Interleukin-2;Kidney;Legal patent;Malignant Neoplasms;Measures;Modality;Multiple Sclerosis;Mus;nanobodies;neutralizing antibody;next generation;novel;novel strategies;novel therapeutics;Organism;Paper;Patient Compliance;Penetration;Peptides;Performance;Pharmacologic Substance;Phase;phase 2 study;Polyethylene Glycols;prevent;Production;Property;Proteins;Public Health;Reporter;response;Ribosomes;Serum Albumin;Side;Site;Specificity;success;Synthesis Chemistry;synthetic biology;System;Technology;technology platform;Testing;Therapeutic;therapeutic candidate;therapeutic development;Tissues;tool;Toxic effect;Translations;Treatment Efficacy;tumor;Tumor Antigens;tumor specificity;Variant;Withdrawal;Work

PROJECT_TITLE: Development of next-generation biologics programmed with multifunctional synthetic chemistries

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-G (10)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biotechnology;Cancer;Diabetes;Osteoarthritis;Wound Healing and Care

ORG_CITY: Irvine

ORG_NAME: SYNTR HEALTH TECHNOLOGIES, LLC

PHR: Project Narrative Automation is key for usability in a clinical setting to help reduce user interaction, provide repeatability and reproducibility, and maintain cleanliness. This project will automate an FDA-registered system for microsizing autologous adipose tissue for the use in regenerative medicine, as well as for dissociating tumor tissue into single cells for cancer diagnostics. This project will provide a valuable role in developing a fully automated system for the use in multiple medical procedures in the regenerative medicine field.

PI_NAMEs: ZOBI, AHMED NABIL (contact)

PROGRAM_OFFICER_NAME: HARGROVE, PASSLEY R

PROJECT_TERMS: Adipose tissue;Adoption;aging population;Anal Fistula;Animal Model;Autologous;Automation;Back;Bluetooth;brain tissue;cancer cell;Cancer Diagnostics;Cell Survival;Cells;Clinical;Clinical Data;Crohn's disease;Dedications;Degenerative polyarthritis;design;design verification;Devices;diabetic;Diabetic Foot Ulcer;diabetic ulcer;Dissociation;Electricity;Electromagnetics;experience;Explosion;Failure;fluid flow;Grant;Growth;healing;Health Technology;Heterogeneity;Human;improved;Individual;Industrialization;Injections;Intra-Articular Injections;Investigation;Kidney Neoplasms;Knee joint;Knee Osteoarthritis;Liver;Malignant Neoplasms;Mammary Gland Parenchyma;manufacturability;Marketing;Medical;Microfluidics;Modality;model design;Motor;North America;novel;Obesity;Operative Surgical Procedures;Patients;Phase;Physicians;Population;Procedures;Process;Production;Regenerative Medicine;Reproducibility;Role;Rotation;Signal Induction;Signal Transduction;simulation;single cell analysis;Small Business Innovation Research Grant;Surface;System;Technology;technology platform;Testing;Time;tissue processing;Tissue Sample;Tissues;Translating;transmission process;Tumor Tissue;Update;usability;Validation;Weight-Bearing state;wireless;wound closure

PROJECT_TITLE: Device Automation of an FDA-cleared CD-Microfluidic Platform for Rapid Tissue Microsizing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (12)]


ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Narrative Obesity is a pervasive disorder linked to serious medical complications and reaching epidemic proportions in the United States. This proposal seeks to investigate the role of thrombospondin/a2d-1 signaling in the ventromedial hypothalamus facilitating feeding control and glucose and lipid metabolism in a body-weight independent manner. These investigations will inform new avenues for the treatment of obesity-associated metabolic disorders and mechanisms underlying metabolic dysfunction in individuals treated with gabapentinoid drugs, known to inhibit a2d-1 function.

PI_NAMEs: RIOS, MARIBEL  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Adult;Affect;Agreement;Analgesics;Animals;anti-epileptic agents;Astrocytes;Behavior;Binding;blood glucose regulation;Body Weight;Brain;Brain region;Brain-Derived Neurotrophic Factor;Calcium;Calcium Channel;Cardiovascular Diseases;CD36 Antigens;Cell surface;Cells;Clinical;Data;Deposition;Diabetes Mellitus;Diet;diet-induced obesity;dietary;Disease;Dyslipidemias;Eating;Electrophysiology (science);energy balance;Energy Metabolism;Epidemic;Equilibrium;Excitatory Synapse;Exhibits;Fasting;Fatty acid glycerol esters;Fatty Liver;feeding;Fiber;gabapentin;gain of function;Genetic;Glucose;Glucose Intolerance;glucose metabolism;glycemic control;Health;Hepatic;High Fat Diet;Homeostasis;Human;Hyperphagia;Hypothalamic structure;improved;in vivo;Individual;Insulin Resistance;Investigation;knock-down;Link;lipid metabolism;Lipids;Liver;male;Maps;Measures;Mediating;medical complication;Metabolic;Metabolic Control;Metabolic Diseases;Metabolic dysfunction;Modeling;Monitor;Morbid Obesity;Mus;mutant;neuronal survival;Neurons;neurotransmitter release;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 2;novel;Obesity;obesity treatment;obesogenic;Output;Overweight;Pathologic;Pathway interactions;Pharmaceutical Preparations;Photometry;Physiology;Play;Population;Predisposition;pregabalin;prevent;receptor;Regulation;response;Risk Factors;Rodent;Role;Signal Transduction;Synapses;Synaptic plasticity;Synaptic Transmission;synaptogenesis;Testing;thrombospondin 3;Thrombospondins;United States;Variant;Viral;voltage

PROJECT_TITLE: Alpha2/delta1- thrombospondin-3 signaling in the central control of metabolic function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-S (02)]


NIH_SPENDING_CATS: Aging

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative Autophagy is a fundamental biological process with broad impact on human health, including a number of age- related diseases, such as neurodegeneration, cancer, infection and immunity, inflammation and allergy, metabolic diseases and diabetes, muscle atrophy, as well as the aging process itself. The realization of the broad impact of autophagy in human health is in part the result of vigorous scientific exchange facilitated by previous Gordon Research Conferences (GRC) on autophagy. The 2024 GRC meeting on autophagy will be instrumental in communicating the newest molecular insights of the role and regulation of autophagy in aging and age-related disorders, as well as highlight the allied processes of lysosomal secretion and lysosomal membrane repair.

PI_NAMEs: HURLEY, JAMES H (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Address;Affect;age-related disease;Aging;aging mechanism;aging process;aging related;Ally;Area;Autophagocytosis;Biological Models;Biological Process;Biology;Biophysics;Chronic;Collaborations;Communicable Diseases;Communication;Communities;Complex;Data;design;Development;Developmental Process;Diabetes Mellitus;Disease;Ensure;Environment;Faculty;Feedback;Fostering;Foundations;Functional disorder;Future;Genes;Goals;graduate student;Health;healthspan;Homeostasis;Human;human disease;Hypersensitivity;Immunity;improved;Infection;Inflammation;Inflammatory;insight;interest;International;Italy;Lysosomes;Malignant Neoplasms;meetings;Membrane;Membrane Protein Traffic;Metabolic Diseases;Methodology;Molecular;Muscular Atrophy;Nerve Degeneration;Neurodegenerative Disorders;next generation;Nobel Prize;novel strategies;novel therapeutics;Oral;Participant;Pathologic Processes;Physiological;Physiological Processes;Physiology;Play;Postdoctoral Fellow;posters;Process;programs;Regulation;repaired;Request for Proposals;Research;Research Personnel;Role;Scientist;Seminal;Series;Signal Transduction;Specialist;Stress;symposium;Therapeutic;Time;Tissues;Vesicle;Woman;Work

PROJECT_TITLE: 2024 Autophagy in Stress, Development and Disease Gordon Research Conference

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Deepening our understanding of how fetal versus adult hematopoiesis will provide insight into how developmental context influences hematopoietic stem cell function. This project aims to investigate the unique transcriptional role of a novel hematopoietic regulator, BCLAF1, in fetal and adult HSCs. Successful completion of the aims in this proposal would provide insight into genetic and transcriptional pathways governing repopulation and renewal.

PI_NAMEs: CROWLEY, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Address;Adult;Affect;Age;B-Lymphocytes;Biological Assay;Birth;Blood;Blood Cells;Bone Marrow;Bone Marrow Cells;Bone Marrow Transplantation;Cell Count;Cell Lineage;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cleavage Under Targets and Release Using Nuclease;Cues;Data;daughter cell;Development;DNA Binding;DNA Binding Domain;DNA Damage;Embryo;Embryonic Development;Epigenetic Process;Equilibrium;exhaustion;Family;fetal;Fetal Development;Fetal Liver;Fetal Reduction;Flow Cytometry;Genes;Genetic;Genetic Transcription;Germ Lines;Goals;Hematopoiesis;Hematopoietic;Hematopoietic Cell Production;hematopoietic stem cell differentiation;hematopoietic stem cell expansion;hematopoietic stem cell fate;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Homeostasis;Injury;insight;jun Oncogene;Killer Cells;Kinetics;knock-down;Knockout Mice;Leukocytes;Life;loss of function;Lymphopoiesis;Maintenance;Malignant Neoplasms;Measures;migration;mouse model;Mus;novel;Output;Parents;Pathway interactions;perinatal period;Phenotype;Poly C;Poly I-C;Population;post-transplant;Process;Production;progenitor;Proliferating;reconstitution;Regulation;Reporting;Research;residence;response;restraint;Role;self-renewal;Sorting;Stem Cell Development;stem cell function;Stem cell transplant;stem cells;Stress;Testing;Time;transcription factor;Transcription Factor AP-1;Transcription Process;Transcription Repressor;Transplantation;Up-Regulation

PROJECT_TITLE: BCLAF1 regulates expression of AP-1 genes and hematopoietic stem cell repopulating activity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Digestive Diseases;Infectious Diseases;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE  This project will expand fundamental knowledge on the selective forces driving the ecological development of the preterm gut microbiome, as well as the basic biological functions of IgA in controlling pathobionts. Using longitudinally collected preterm infant stool samples from a prospective cohort study, the proposed research will identify signature patterns of preterm gut microbiota development, how pathobionts evolve to induce necrotizing enterocolitis (NEC), and the role of breast milk IgA in influencing these outcomes. Findings will reveal new insights into IgA modulation of the microbiota, which has important implications for the development of microbiome- and immunoglobulin-based therapies against NEC.

PI_NAMEs: TIN, CHRISTINE MELODY (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Acceleration;Address;Affect;Anaerobic Bacteria;Anti-Bacterial Agents;anti-IgA;Antibodies;Bacteria;Bar Codes;Bifidobacterium;Binding;Biological Process;Biology;Birth;career;Cells;Childhood;Clinical;cohort;Collaborations;Communities;curative treatments;Data;Data Set;Databases;design;Development;Diagnosis;Disease;driving force;Ecosystem;Enterobacteriaceae;Evolution;Exhibits;Failure to Thrive;Feces;Fetal health;Flow Cytometry;Genes;Genetic;genetic variant;Genomics;Goals;gut dysbiosis;gut microbiome;gut microbiota;Health;Human Milk;Immune;Immunoglobulin A;Immunoglobulins;improved;In Situ;Individual;Infant;Infant Development;infant gut microbiome;Inflammatory Bowel Diseases;insight;Intestines;Knowledge;Label;Laboratories;Life;Link;longitudinal analysis;Maternal-fetal medicine;microbial;microbial signature;microbiome;microbiome alteration;microbiota;microbiota profiles;Milk;Mothers;mouse model;Mutation;Necrotizing Enterocolitis;Neurodevelopmental Impairment;new technology;novel strategies;Outcome;pathobiont;Pathogenesis;patient oriented;Patient-Focused Outcomes;Patients;Pattern;Physicians;Population;Population Dynamics;Population Sizes;Predisposition;Premature Infant;pressure;prevent;Prospective Studies;Prospective, cohort study;Reaction;Research;Resistance;Resolution;response;Risk;RNA;Role;Sampling;Scientist;Secretory Immunoglobulin A;Shapes;Source;stool sample;Survivors;targeted treatment;Testing;Therapeutic;Time;Training;trait;Variant;Work

PROJECT_TITLE: Breast Milk IgA Exerts Selective Pressure on the Preterm Gut Microbiome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-L (20)]


NIH_SPENDING_CATS: Genetics;Microbiome

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE An understanding of the complex microbial signaling networks in the human microbiome has led to many insights in health and disease, and yet, little is known about the impacts of archaea or archaeal signaling in and on our bodies. My study will elucidate a novel signaling pathway in the model archaeon Haloferax volcanii. Discoveries in cell-signaling in archaea will begin to unravel the intricacies of signaling among all three domains of life, lead to applications in antibacterial medicine, and reveal a more cohesive understanding of the healthy human microbiome.

PI_NAMEs: CHATTERJEE, PRIYANKA  (contact)

PROJECT_TERMS: Agar;Anabolism;analog;Analytical Chemistry;Anti-Bacterial Agents;aqueous;Archaea;Area;bacterial community;Biological Assay;Bypass;candidate identification;Cell secretion;Cell Shape;Cells;Cellular biology;Chemistry;Chromatography;circadian pacemaker;Co-Immunoprecipitations;Coin;Collaborations;Communication;Complement;Complex;Custom;Data;Deoxyribonucleases;Development;Disease;Disease Outcome;ethyl acetate;Flagella;Fluorescence-Activated Cell Sorting;Fractionation;gene discovery;Gene Expression;Genes;Genomic Segment;Growth;Haloferax volcanii;Health;Homologous Gene;Homologous Protein;Human;Human Microbiome;in vivo;Industry;insight;intercellular communication;Investigation;knockout gene;Lead;Libraries;Life;Link;Mass Spectrum Analysis;Mediating;Medicine;Metagenomics;Microbe;microbial;Microbial Biofilms;microbial community;microbiome;microbiome research;microorganism interaction;Modeling;Molecular;Morphology;Motility;mutant;Mutation;novel;Nutrient;Nutrient Depletion;Organic solvent product;Pathway interactions;Pattern;Peptide Hydrolases;Phase;Phenotype;Physiology;Point Mutation;polyclonal antibody;Population Density;protein crosslink;protein protein interaction;Proteins;Proteomics;quorum sensing;Regulation;Reporting;response;Ribonucleases;Rod;Role;screening;Shapes;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;Site;small molecule;Structure;Surface;Swimming;System;Techniques;Time;uptake;Validation

PROJECT_TITLE: Cell-cell signaling in archaea: How Haloferax volcanii talk to each other

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: More than 11 million units of blood are used annually in the United States to treat patients with anemia. The overall goal of our collaborative research is to gain a better understanding of red cell progenitor self-renewal to facilitate the expansion of human self-renewing erythroblasts with the long-term goal of generating red blood cells for clinical use in blood banks and transfusion therapy.

PI_NAMEs: PALIS, JAMES  (contact);STEINER, LAURIE A.

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acute;Adult;Anemia;Binding;Blood;Blood Banks;Blood Transfusion;BMI1 gene;Body mass index;cancer cell;Cell division;cell type;Cells;Child;Cholesterol Homeostasis;Chromatin;Clinic;Clinical;Complex;cytokine;Data;daughter cell;Development;Embryo;England;Epigenetic Process;epigenome;Erythroblasts;Erythrocytes;Erythroid;Erythroid Cells;Erythropoiesis;Generations;Genes;Genetic Transcription;Glucocorticoids;Goals;Histone H2A;Human;Human body;Hypoxia;In Vitro;in vivo;Ink;innovation;life span;Lysine;Marrow;member;Mus;Normal Cell;novel;Output;overexpression;Parents;Pathway interactions;Patients;Phase;Process;Production;progenitor;Proliferating;Regulation;Research;Research Project Grants;response;Reticulocytes;Role;self-renewal;Source;stem cell function;stem cell self renewal;Stress;System;Testing;Transcriptional Regulation;transcriptome;Transfusion;ubiquitin-protein ligase;United States;WFDC2 gene;Yolk Sac

PROJECT_TITLE: Erythroid Self-Renewal

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Digestive Diseases;Foodborne Illness;Genetics;Infectious Diseases;Pediatric

PHR: PROJECT NARRATIVE Rotavirus infections are a major global health concern. A better understanding of rotavirus pathogenesis is imperative to the development of more effective vaccines and life-saving treatments. The proposed work will identify the mechanism of rotavirus extraintestinal dissemination and tissue tropism, setting the stage for preventing and treating secondary complications after enteric viral infections.

PI_NAMEs: ANTIA, AVAN  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: 3-Dimensional;Affect;Age;Antigen-Presenting Cells;Antigens;Apical;Biliary Atresia;Biological Assay;Blood;Bypass;Capsid Proteins;CAV1 gene;Caveolae;caveolin 1;Caveolins;cell growth;cell type;Cells;Cessation of life;Child;Childhood;Clinical;CRISPR/Cas technology;cyanine dye 5;Detection;Development;Diarrhea;Disease;early childhood;Electrical Resistance;Endocytosis;Enteral;enteric infection;enteric pathogen;enteric virus infection;Epithelial Cells;Epithelium;experimental study;Face;Family suidae;Fever;fluorescein isothiocyanate dextran;fluorescence imaging;Gastroenteritis;gastrointestinal;Genes;global health;Harvest;Hepatobiliary;Hepatocyte;Homeostasis;Human;Immune;Immune response;Immunofluorescence Microscopy;immunogenicity;improved;In Vitro;in vivo;Incubated;Infection;Insulin-Dependent Diabetes Mellitus;Intestinal Bypasses;intestinal epithelium;Intestines;intraperitoneal;Knock-out;knockout gene;Knockout Mice;Label;Life;Link;Liver;LoxP-flanked allele;Lymphoid Tissue;M cell;Measures;Mediating;Mediator;Molecular;monolayer;mortality;mouse model;mucosal vaccine;Mus;Nature;Oral;Organ;Organoids;Outpatients;Pancreas;pathogen;Pathogenesis;pathogenic bacteria;pathogenic virus;Pathway interactions;Permeability;Physiological;Plaque Assay;Play;prevent;Process;pup;Quantitative Reverse Transcriptase PCR;rational design;Reovirus;Reporting;RNA;Role;Rotavirus;Rotavirus Infections;Route;Sampling;Side;Site;Small Intestines;stool sample;Structure of beta Cell of islet;suckling;Surface;System;Testing;Tight Junctions;Time;tissue tropism;Tissues;transcriptome sequencing;transcytosis;Tropism;uptake;Vaccines;villin;Viral;Viral Gastroenteritis;Viral Load result;viral RNA;Viremia;Virion;Virus;Visceral;Visit;Visualization;Work

PROJECT_TITLE: Elucidating the role of intestinal M cells in rotavirus enteric infection, systemic dissemination, and pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-S (20)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: ORTHOPEDICS

PHR: PROJECT NARRATIVE Rotator cuff tears (RCTs) are the most common shoulder injury and are often surgically repaired. Unfortunately, rates of retear are high and have been clinically correlated to rotator cuff muscle fatty infiltration and fibrosis—the origins of which remain unclear; however, likely involve an interstitial population of mesenchymal cells known as fibroadipogenic progenitors (FAPs). Utilizing murine models of massive RCTs, genetic lineage tracing/reporter analyses, as well as sophisticated bulk and single cell RNA-sequencing assays, functional measures, and lightsheet microscopy we will determine the precise cellular and molecular role(s) for FAP/s in the RCT-associated muscle atrophy pathology.

PI_NAMEs: RUECKERT, HELEN  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Address;Adipocytes;adipokines;Adolescent;Adult;Age Months;Articular Range of Motion;Atrophic;Biological Assay;Blood Vessels;Candidate Disease Gene;Cells;Clinical;Contralateral;cytokine;Data;Data Set;experimental study;Failure;Fatty acid glycerol esters;fibrogenesis;Fibrosis;Flow Cytometry;Gene Expression;Genes;Genetic;Genetic Recombination;Harvest;Heterogeneity;Histologic;Human;Immune;Infiltration;infraspinatous muscle;injured;Injury;insight;interstitial;Intramuscular;Label;Lead;Light;lipid biosynthesis;Lower Extremity;Measures;Mesenchymal;Microscopy;Minor;Modeling;Molecular;mouse model;Mus;Muscle;Muscle Fibers;Muscle function;muscle regeneration;Muscle satellite cell;Muscular Atrophy;Natural regeneration;Nerve;nerve transection;Neuromuscular Junction;novel;Operative Surgical Procedures;Pathology;Phenotype;Play;Population;Population Heterogeneity;Prevalence;prevent;progenitor;repaired;Reporter;Role;Rotator Cuff;rotator cuff tear;sham surgery;Shoulder;shoulder injury;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Skeletal Muscle;Sorting;Source;Stains;stem cell differentiation;stem cell expansion;stem cells;Structure;subscapularis muscle;supraspinatus muscle;Surgical Models;Tamoxifen;Tendon structure;Testing;Tissues;Tomatoes;transcriptome sequencing;Upper arm;virtual;Work

PROJECT_TITLE: The role(s) of muscle resident fibro-adipogenic progenitor cells in massive rotator cuff tear pathologies.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-C (20)]