NIH_SPENDING_CATS: Lung;Pulmonary Hypertension

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The immune system likely contributes to the development of pulmonary hypertension (PH) by excessive inflammation, which causes disease in the lung blood vessels. Our research investigates how dendritic cells engage with other immune cells such as T cells and monocytes, resulting in inflammation and pulmonary hypertension. Our main approach is by studying mice exposed to hypoxia, since hypoxia- induced PH affects over 140 million people worldwide.

PI_NAMEs: MICKAEL, CLAUDIA SILVA (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Acute;adaptive immune response;adaptive immunity;Address;Affect;Altitude;Antigen-Presenting Cells;Area;Automobile Driving;B-Lymphocytes;Blood Vessels;Bone Marrow;CD4 Positive T Lymphocytes;CD80 gene;CD86 gene;Cells;chemokine;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;cytokine;Data;Dendritic Cells;Development;Disease;effector T cell;Environment;Etiology;Exposure to;Fibrosis;Flow Cytometry;Foundations;Functional disorder;Goals;Grant;Human;Hypoxia;hypoxia-induced pulmonary hypertension;Immune;Immune response;Immune system;Immunity;Inflammation;Inflammatory;Innate Immune Response;innovation;interstitial;Investigation;ITGAM gene;Knockout Mice;Life Expectancy;Link;Location;Lung;lung hypoxia;lung vascular inflammation;Macrophage;mast cell;Molecular;monocyte;Mus;Natural Immunity;novel;Obstructive Sleep Apnea;pathogen;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Pattern;Persons;Phenotype;Plasma;Population;pressure;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary Hypertension;pulmonary vascular disorder;pulmonary vascular remodeling;Pulmonary Vascular Resistance;recruit;Regulatory T-Lymphocyte;Reporter;Research;Research Personnel;response;right ventricular failure;Right ventricular structure;Role;Scanning;Sense Organs;Shapes;Site;Stimulus;Subcategory;T cell response;T-Lymphocyte;Thrombospondin 1;Tissues;TNFRSF5 gene;Transforming Growth Factor beta;Vascular remodeling;Vascular resistance

PROJECT_TITLE: Novel Role of Classical Dendritic Cells in the pathogenesis of Hypoxia-Induced Pulmonary Hypertension


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Rare Diseases

ORG_CITY: DUARTE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Kaposi sarcoma-associated herpesvirus (KSHV) is the causal agent of Kaposi sarcoma, a common cancer in immunocompromised people (such as HIV/AIDS and transplant patients) and two lymphoid malignancies. We have designed a study to uncover the role of key KSHV glycoproteins in oral and systemic transmission of KSHV ex vivo and in vivo. We expect to generate critical data that will inform future design of an effective prophylactic KSHV vaccine candidate to prevent KSHV infection and its associated cancers.

PI_NAMEs: OGEMBO, JAVIER GORDON (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Africa;Age;Animal Model;Antibodies;Antibody-mediated protection;B-Lymphocytes;Binding;Body Fluids;Callithrix jacchus jacchus;Cell surface;cell type;Cells;Child;Collaborations;Complex;Data;design;Detection;Development;Disease;Endothelial Cells;Endothelium;Epithelial Cells;Epithelium;experimental study;Fibroblasts;Future;Glycoproteins;Goals;Herpesviridae;Herpesviridae Infections;HIV/AIDS;Human;Human body;Human Herpesvirus 8;human model;Iatrogenesis;Immunity;Immunize;Immunocompetent;Immunocompromised Host;immunodeficiency;immunosuppressed;Immunosuppression;In Vitro;in vivo;in vivo Model;Infection;Kaposi Sarcoma;Laboratories;latent infection;Lesion;Lymphocyte;Malignant lymphoid neoplasm;Malignant Neoplasms;Maternal antibody;Measures;Membrane;Modeling;Monoclonal Antibodies;mutant;nonhuman primate;novel;Oral;Oral cavity;oral infection;Pattern;permissiveness;Persons;polyclonal antibody;polyclonal human antibody;Predisposition;prevent;Preventive vaccine;Primary Infection;Primates;prophylactic;receptor;Receptor Cell;Recombinants;Reporting;Research;Risk;Role;Saliva;Sampling;Sexually Transmitted Diseases;Signal Transduction;Site;skin lesion;success;T-Lymphocyte;Testing;Tonsil;tool;transmission process;Transplant Recipients;Tropism;vaccine candidate;vaccine development;Viral;Viremia;Virion;Virus Diseases;Wisconsin;Work

PROJECT_TITLE: Unmasking the roles of viral glycoproteins in oral transmission of KSHV


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Hematology;Orphan Drug;Rare Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE (RELEVANCE) Myelodysplastic syndromes (MDS) are common blood cancers that are characterized by high rates of disease relapse. Our data show that the levels of active longer forms of IRAK4 are very high in MDS cells, are predictive of worse outcomes in patients, and can be used to target disease causing cells. In the proposed studies, we will determine the intracellular pathways activated by IRAK4 in MDS cells, and test the efficacy of novel IRAK4 inhibitors in MDS.

PI_NAMEs: STARCZYNOWSKI, DANIEL ;VERMA, AMIT K. (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute Myelocytic Leukemia;Alternative Splicing;AML/MDS;Biological Assay;biomarker driven;C-terminal;CDK2 gene;Cell Line;Cell Physiology;Cells;Cellular biology;Chronic;Clinical;clinical predictors;Clinical Trials;clinically relevant;Complex;Correlative Study;Data;Death Domain;Disease;Dysmyelopoietic Syndromes;efficacy evaluation;efficacy testing;Exhibits;Exons;Functional disorder;Gene Expression Profile;Genes;Genetic;Growth;Hematopoietic;Hematopoietic Neoplasms;Immune;Immune signaling;In Vitro;in vivo;Induced Mutation;Inflammatory;inhibitor;IRAK4 gene;kinase inhibitor;knock-down;Lead;leukemia;Leukemic Cell;Leukemic Hematopoietic Stem Cell;Link;Lysine;MAP Kinase Gene;Mediating;mutant;Mutation;N-terminal;Nature;novel;Oncogenic;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;phosphoproteomics;Phosphotransferases;potential biomarker;predicting response;Prognosis;Protein Isoforms;Protein-Serine-Threonine Kinases;Publishing;Recurrent disease;Regulation;response;RNA Splicing;Role;Sampling;Serine;Signal Pathway;Signal Transduction;small hairpin RNA;Spliceosomes;Therapeutic;therapeutic target;Therapeutically Targetable;TRAF6 gene;transcriptome sequencing;Ubiquitination;Work;Xenograft procedure

PROJECT_TITLE: Therapeutic targeting of IRAK4 in MDS

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BELLINGHAM

ORG_NAME: NORTHWEST INDIAN COLLEGE

ORG_STATE: WA

PHR: Project Narrative The proposed NWIC NARCH XI has the goals to expand capacity at NWIC to allow more rapid and real- time response to tribal council and AIAN community requests to conduct research in emergent, high priority areas including addressing the consequences of the COVID-19 pandemic crisis on health, resilience and recovery. We propose our Northwest Indian College (NWIC) NARCH XI application as a hedge against the rising tide of racial inequity and social injustice impacting the lives and ultimately the health and mortality of AIAN people. Overall, the application aims to support three tribally-led research projects that address high priority health issues identified by AIAN tribes or tribal organizations, and provide opportunities for AIAN student health careers development and research training.

PI_NAMEs: RASMUS, STACY M. (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Acceleration;Accidental Injury;Accreditation;Address;Alaska Native;Alaska Native population;American;American Indian Population;American Indians;Area;assault;Biological;career development;Chronic;chronic liver disease;Civil Rights;college;Communities;community engagement;community organizations;Complex;COVID-19 pandemic effects;Data;Diabetes Mellitus;Disease;disparity elimination;economic disparity;Economics;Education;Ensure;Ethnic Population;Etiology;Feeds;General Population;Goals;Government;healing;Health;health disparity;health inequalities;Health Priorities;Health Promotion;Healthcare;Home;Homicide;Idaho;improved;Indigenous;Inequity;Infant Mortality;Institution;Intervention;Intramural Research Program;Knowledge;Life;Life Expectancy;Liver Cirrhosis;Measures;member;Minority Groups;Modeling;mortality;Native American Research Center for Health;Native Americans;Opioid;Oregon;Overdose;Personal Satisfaction;Persons;Pharmaceutical Preparations;poor health outcome;Positioning Attribute;Problem Solving;programs;promote resilience;Public Health;Race;racial disparity;Reaction Time;Recording of previous events;Recovery;Reporting;Research;Research Personnel;Research Project Grants;Research Training;resilience;Resources;Respiratory Disease;Rights;Risk;Rural;Science;Self-Injurious Behavior;Site;social;Students;success;Suicide;Translations;Trauma;tribal college;tribal community;Tribal Council;tribal organization;Tribally Based Participatory Research;Tribes;United States;United States National Institutes of Health;Universities;Washington;Water

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y(55)]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PI_NAMEs: MCCLURE, LESLIE AIN (contact)

PROJECT_TERMS: Accountability;Address;Aging;Applications Grants;Area;Attention;Biomedical Research;career;career development;Chronic Disease;cohort;college;Communities;Dedications;Development;Development Plans;Discipline;Discipline of Nursing;diversity and inclusion;early-career faculty;Educational process of instructing;Educational workshop;Ensure;Environment;ethnic diversity;Ethnic Origin;Etiology;Evaluation;Event;evidence base;expectation;Faculty;faculty mentor;faculty support;Funding;Future;Gender;gender diversity;Goals;Grant;Grant Review;Growth;Health;Health Disparities Research;health disparity;Health Occupations;improved;Individual;innovation;Intelligence;interdisciplinary approach;Interdisciplinary Study;intersectionality;Intervention;Investments;Learning;Life Cycle Stages;Lived experience;Manuscripts;Medicine;member;Mentors;Mentorship;Modeling;Outcome;Pathway interactions;peer;peer coaching;peer support;Physical environment;Policies;population health;Process;professor;programs;Public Health;Published Comment;Race;racial diversity;Research;research and development;Research Personnel;Research Support;Risk Factors;scale up;Scholarship;Schools;Science;Shapes;Social Environment;Structure;success;Sum;Teacher Professional Development;Theoretical Studies;Translating;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Catalyzing Systemic Change at Drexel University to Support Diverse Faculty in Health Disparities Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-Y]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

PROJECT_TERMS: Acceleration;Agreement;Alaska;Alaska Native;American Indians;Award;Back;Collaborations;college;Communication;Communities;community based participatory research;community partners;Data;Data Analytics;Development;Education;Equity;Evaluation;Faculty;Funding Opportunities;Goals;Health;health disparity;health equity;Health Status;higher education;improved;Information Distribution;Infrastructure;Institution;Institutional Review Boards;interest;Knowledge;Leadership;meetings;member;Mentorship;Mission;Monitor;Native American Research Center for Health;outreach;Ownership;Policy Maker;Positioning Attribute;program dissemination;Program Evaluation;programs;Public Health;Puyallup;Recording of previous events;Reporting;Research;Research Project Grants;Research Support;Resources;Role;Safety;Science;Services;Site;student mentoring;Students;success;Training;Training Activity;Translational Research;tribal community;tribal health;tribal leader;tribal Nation;tribal organization;Tribally Based Participatory Research;Tribes;United States National Institutes of Health;Universities;Vision;Washington

PROJECT_TITLE: NWIC NARCH XI Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Chronic Pain;Clinical Research;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because identification of validated biomarker signatures in taxane-treated breast cancer patients associated with increased likelihood of developing neuropathic pain may contribute to the development of novel approaches to personalize chemotherapy in patients, including altering dosing or using a different chemotherapeutic, reducing the risk for developing neuropathic pain and the development of novel approaches to treat or slow the progression of neuropathic pain by modifying pathways prior to taxane-treatment and before initiation of symptoms. The proposed research is relevant to the NIH mission pertaining to the generation of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.

PI_NAMEs: FOSS, JOSEPH F;JOHNSON, KENWARD B;ROTROFF, DANIEL  (contact)

PROGRAM_OFFICER_NAME: ARUDCHANDRAN, RAMACHANDRAN NMN

PROJECT_TERMS: Address;Affect;Algorithms;Anxiety;Area;Behavior;Biochemical;Biological Markers;biomarker identification;biomarker panel;biomarker signature;biomarker validation;Blood specimen;blood-based biomarker;Breast Cancer Patient;candidate identification;candidate marker;Cessation of life;chemokine;chemotherapeutic agent;chemotherapy;Chemotherapy-induced peripheral neuropathy;Classification;Clinical;clinical practice;Complex;cytokine;Development;diagnostic tool;disability;DNA Methylation;Dose;Dose Limiting;Early treatment;epigenome;experience;Generations;Genes;Genome;genome-wide;Genotype;Goals;Health;high risk;improved;Individual;innovation;instrument;Knowledge;Life;Machine Learning;Malignant Breast Neoplasm;Measures;Mental Depression;Messenger RNA;metabolome;Metastatic breast cancer;Mission;Modeling;Molecular;molecular marker;Monitor;Motor;multiple omics;Nature;novel;novel marker;novel strategies;Numeric Rating Scale;oncotype;Organism;Outcome Measure;Pain;pain catastrophizing;Pain Free;Pain intensity;Pain interference;pain score;pain-related disability;painful neuropathy;Pathway interactions;Patient Outcomes Assessments;Patients;Peripheral;personalized chemotherapy;personalized medicine;Phase;Phenotype;Physical Function;predictive marker;predictive signature;Predisposition;prevent;Public Health;Quality of life;Questionnaires;Recurrence Score;Research;response;Risk;Risk Reduction;ROC Curve;Sampling;Secondary to;Sensory;side effect;Standardization;Symptoms;System;taxane;Testing;Therapeutic;therapy outcome;Time;tool;Toxic effect;trait;transmission process;United States National Institutes of Health

PROJECT_TITLE: Multi-Omic Biomarkers for Neuropathic Pain Secondary to Chemotherapy


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence

ORG_CITY: Nashville

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE NIMH recognizes that rigorous research is essential to identifying complex mechanisms underlying suicide risk disparities experienced by sexual and gender minority (SGM) populations and developing interventions to reduce such disparities. Consistent with this NIMH programmatic priority, this project will examine precursors to suicidal ideation among SGM adolescents using an innovative mixed-methods approach incorporating qualitative data, real-time micro-longitudinal data collection methods, and preliminary intervention development. Given the disproportionate risk for suicide among SGM adolescents and the dearth of prospective research involving this high-risk population, this project represents a novel scientific advancement to inform suicide prevention.

PI_NAMEs: CLARK, KIRSTY A (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Acute;adaptive intervention;Address;Adolescence;Adolescent;adolescent health;Assertiveness;assessment application;Attitude;Behavioral;bullying;career;Cause of Death;Cellular Phone;Clinical;Cognitive;Cognitive Therapy;Complex;Data;Data Collection;design;Development;Disparity;Ecological momentary assessment;Educational workshop;Environment;experience;Exposure to;Feeling hopeless;Feeling suicidal;Focus Groups;gender minority group;gender minority youth;Global Positioning System;Goals;high risk;high risk population;Hospitalization;Individual;innovation;inpatient psychiatric treatment;Inpatients;Interdisciplinary Study;internalized stigma;Intervention;Interview;Link;Measures;Mediation;meetings;Mentors;Mentorship;Methods;minority disparity;Monitor;National Institute of Mental Health;Nature;novel;Observational Study;Ownership;Participant;Patient Self-Report;perceived stress;Population;preventable death;programs;prospective;psychological stressor;real time monitoring;reducing suicide;Reporting;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Research Scientist Award;Resources;responsible research conduct;Risk;Safety;Scientific Advances and Accomplishments;Scientific Inquiry;Scientist;self esteem;Self-control as a personality trait;Sexual and Gender Minorities;sexual minority group;sexual minority youth;skill acquisition;skills;skills training;social stigma;Stress;stressor;substance use;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Surveys;symposium;Taxes;technology platform;Testing;therapy development;Thinking;Time;Training;transgender;United States;Universities

PROJECT_TITLE: Predicting and Preventing Suicidal Ideation among High-Risk Sexual and Gender Minority Adolescents

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cannabidiol Research;Cannabinoid Research;Chronic Pain;Complementary and Integrative Health;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Natural Products;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Racial and Ethnic Minority Health Research;Rural Health;Sleep Research;Social Determinants of Health;Substance Misuse;Therapeutic Cannabinoid Research

PROJECT_TERMS: Adult;Affect;Age;Alaska Native;Alaska Native population;American Indian Population;American Indians;Analgesics;Anti-Anxiety Agents;Anxiety;Arthritis;Cannabidiol;Cannabis;Cannabis retail;cannabis use behavior;care seeking;Caring;chronic pain;chronic pain management;chronic painful condition;Clinic;clinical care;college;Communities;comorbidity;Consultations;Data;Data Analyses;Data Collection;data infrastructure;data repository;demographics;Diabetic Neuropathies;Discipline of Nursing;District of Columbia;Economic Factors;Enrollment;Event;experience;Female;graduate student;Grant;healing;health care availability;Hemp;improved;Industry;Institutional Review Boards;Interview;Legal;Life;Low Back Pain;marijuana decriminalization;marijuana legalization;marijuana use;marijuana user;Marketing;Measures;Mediating;Medical;Medical Marijuana;Medicine;Mental Depression;Mental Health;Mentorship;Methods;Native American Research Center for Health;negative affect;nonmedical use;older adult;opioid misuse;opioid mortality;Pain;Pain intensity;Pain interference;Pain management;pain outcome;pain reduction;pain relief;Pain Research;Participant;Patients;Pattern;Persons;Pharmacy facility;Pilot Projects;Policy Maker;Post-Traumatic Stress Disorders;Poverty;prescription opioid;Prevention;Procedures;programs;Provider;Puyallup;Qualitative Methods;Race;Recreation;Reporting;Research;Sampling;Science;Self Efficacy;sex;Sleep;Sleep Disorders;Sleeplessness;social factors;Students;Tetrahydrocannabinol;Time;Training;Tribes;undergraduate student;Universities;vehicular accident;Washington

PROJECT_TITLE: Association between cannabis and pain outcomes in a Tribally operated clinic


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: KAIMAL, GIRIJA  (contact)

PROJECT_TERMS: Accountability;Address;Adoption;Award;career;Career Choice;Climate;clinical practice;cohort;Collaborations;college;Communities;Data Set;design;Discipline of Nursing;Ensure;Environment;Equity;Evaluation;experience;Extramural Activities;Faculty;Feedback;Funding;Goals;Grant;Health Disparities Research;health equity;Health Occupations;improved;Individual;Institution;International;intersectionality;Intervention Studies;Life;Logic;Measures;member;Mentors;Methods;minority disparity;minority health;Modeling;organizational climate;organizational readiness;Outcome;Output;pedagogy;Policies;Population Sciences;Process;Productivity;Program Sustainability;programs;Public Health Schools;Publications;recruit;Reporting;Research;Research Activity;Research Support;response;Scholarship;Scientific Evaluation;Scientist;Self Assessment;Social isolation;Social Justice;Social Values;success;Teacher Professional Development;Textiles;tool;underserved community;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Catalyzing Systemic Change at Drexel University to Support DiverseFaculty in Health Disparities Research


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative Metabotropic glutamate receptors (mGluRs) are central regulators of glutamate signaling in the brain and are currently considered key drug targets for neurological disorders such as autism, anxiety, schizophrenia, Parkinson's disease, and addiction. The proposed research will apply cutting-edge methodologies that will allow us to directly watch receptors as they interact with ligands and function, to learn about how they function, with unprecedented accuracy. This knowledge may hold the key for the development of effective therapeutics for difficult-to-treat human diseases.

PI_NAMEs: VAFABAKHSH, REZA  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: addiction;Affect;Allosteric Regulation;Anxiety;Architecture;autism spectrum disorder;Binding Sites;Biochemical;Biological;Biological Assay;Biophysics;Brain;Calcium-Sensing Receptors;Cell membrane;Cells;Chemicals;Cholesterol;Complement;Complex;Computing Methodologies;Coupled;Coupling;crosslink;Cysteine-Rich Domain;Cytoplasm;Data;design;Development;dimer;Dimerization;drug development;Drug Targeting;Environment;Epilepsy;Family;Fluorescence Resonance Energy Transfer;Fragile X Syndrome;Functional disorder;Funding;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Glioma;glutamatergic signaling;Glutamates;Goals;Grant;Heterodimerization;Human;human disease;In Vitro;insight;intercellular communication;Knowledge;Learning;Ligand Binding;Ligands;Lipids;live cell imaging;Malignant Neoplasms;Marketing;Mediating;member;Membrane;Membrane Proteins;metabotropic glutamate receptor 2;Metabotropic Glutamate Receptors;Methodology;Methods;Microscopy;millisecond;Modeling;Molecular;Molecular Conformation;Mood Disorders;Motion;multidisciplinary;Mutagenesis;nanometer;Nature;Nervous System Disorder;neuropathology;neuroregulation;new technology;novel;Parkinson Disease;Pattern;Pharmaceutical Preparations;Physiological;Process;Property;Protein Conformation;Protein Dynamics;Protein Engineering;Protomer;Psychotic Disorders;rational design;receptor;Receptor Activation;receptor function;Receptor Signaling;reconstitution;Reporter;Research;Resolution;Role;Schizophrenia;Sensory;Shapes;side effect;Signal Pathway;Signal Transduction;Signaling Molecule;single molecule;single-molecule FRET;Site;spectroscopic survey;Spectrum Analysis;Structure;Techniques;therapeutically effective;Time;Tissues;Transmembrane Domain;Venus Flytrap;Visualization;Work

PROJECT_TITLE: Quantitative analysis of metabotropic glutamate receptor activation and modulation

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Arctic;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Adoption;Adult;Advocacy;Alaska;Alaska Native;Alaska Native population;alcohol use disorder;Alcohols;American Indian Population;Area;Authorization documentation;behavior test;behavioral health;Board Certification;career development;Caring;Cause of Death;Certification;Clinic;Clinical;clinical care;Clinical Trials;college;Communities;Community Health Aides;community setting;Competence;Counseling;COVID-19 pandemic;Data;disparity reduction;Drug Addiction;Early identification;Educational Curriculum;Effectiveness;Equilibrium;evidence base;experience;Family;Goals;Grief reaction;Health;health care service;health disparity;Health education;health organization;Health Personnel;Health Services;Health Services Accessibility;Health system;Healthcare;implementation science;improved;indigenous community;Individual;Interview;Measures;Mental Depression;Mental Health;Modeling;Native American Research Center for Health;native youth;Outcome;Pathway interactions;Persons;Process;Professional counselor;programs;Provider;Public Health;public health relevance;Reporting;Research;response;Role;Route;Rural;rural Americans;satisfaction;Scanning;Service delivery model;Services;severe mental illness;skills;Stress;Structure;Students;substance misuse;Substance Use Disorder;suicidal behavior;suicidal risk;Suicide;suicide rate;Supervision;Surveys;System;Technology Transfer;Testing;Training;Training and Education;Translational Research;Trauma;tribal health;tribal organization;Tribes;United States Indian Health Service;Variant

PROJECT_TITLE: Alaska Behavioral Health Aide Program: Formative research to evaluate a rural training and service delivery model to reduce disparities in AN/AI mental health and substance use disorders


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: Post-9/11 Veterans' community reintegration is often characterized by psychosocial stressors and adjustment challenges (e.g., social support disruption, relationship difficulties). Depression, which is common among reintegrating post-9/11 Veterans, can further complicate the reintegration process. The proposed project seeks to improve community reintegration and reduce depression among post-9/11 Veterans. To accomplish this, the proposed project will pilot test the REconnecting to Civilian Life using Activities that Improve Mindfulness (RECLAIM) intervention, which is a virtual multi-component mindfulness-based intervention. Input will be elicited from RECLAIM participants to explore experiences in the intervention and suggestions for improvement. Participant feedback will be used to refine the RECLAIM protocol. We will consult with a panel of Veterans and operational partners to gather Veteran feedback on the revised RECLAIM protocol manual. Findings will contribute to VA efforts to improve Veterans' mental health.

PI_NAMEs: SHUE, SARAH  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Anxiety;Applications Grants;Area;arm;Award;care delivery;cohort;Collaborations;Community Healthcare;community reintegration;Consult;Control Groups;cost;critical period;Data;depressive symptoms;design;Diagnosis;Education;effectiveness evaluation;Ensure;experience;Family;feasibility testing;Feedback;Funding;Future;Goals;Health;Health Services Research;Healthcare Systems;hybrid type 1 trial;improved;innovation;interest;internalized stigma;Intervention;intervention refinement;Interview;Investigator-Initiated Research;Life;Manuals;Meditation;Mental Depression;Mental Health;Mental Health Services;Methodology;Methods;Military Personnel;military service;mindfulness;mindfulness intervention;mindfulness meditation;Modality;Outcome;Outcome Assessment;Participant;Patient-Centered Care;Patients;Personal Satisfaction;Persons;Pilot Projects;pilot test;post 9/11;Procedures;Process;programs;Protocols documentation;psychoeducation;psychosocial adjustment;psychosocial outcome;psychosocial stressors;Randomized;randomized controlled design;randomized trial;Randomized, Controlled Trials;recruit;Reporting;Research;research and development;Research Priority;Resources;Sampling;Scanning;Services;Sleep;Social isolation;Social support;Strategic Planning;Stress;Structure;Subgroup;Suggestion;Testing;treatment arm;United States Department of Veterans Affairs;Update;Veterans;Veterans Health Administration;virtual;virtual delivery;virtual intervention;whole health;Work;Yoga

PROJECT_TITLE: Pilot Testing a Virtual Mindfulness-Based Intervention Aimed at Improving Reintegrating Veterans' Health Outcomes

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project narrative Patient T cells genetically engineered with chimeric antigen receptors (CAR-T) have shown unprecedented anti- tumor activity in hematological malignancies, however, this approach is patient specific and has limited activity in solid tumors. In this proposal, we will investigate the use of genetically engineered iNKT cells as an off-the- shelf, cellular platform with intrinsic tumor homing and microenvironment modulating effects to increase therapy availability and effectiveness in solid tumors. Allogeneic CAR-iNKT cells will be evaluated in pet dogs with spontaneous osteosarcoma to determine optimal preconditioning regimens, safety and tolerability of cell dose and effects of different iNKT cell profiles on their persistence, survival, tumor homing, and immunomodulatory capacity that aims to increase anti-tumor activity and prolong disease free survival, paving the way to advancing this approach in human cancer patients.

PI_NAMEs: MASON, NICOLA J (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Acceleration;Address;Adjuvant;Adoptive Cell Transfers;Adoptive Transfer;advanced disease;Affect;Aftercare;Agonist;Allogenic;antileukemic activity;antitumor effect;Antitumor Response;Autologous;Biological;Biological Assay;Biopsy;Blood Component Removal;Bone Marrow;cancer cell;Cancer Model;Cancer Patient;Canis familiaris;Caring;cell bank;Cell secretion;Cells;chemokine;chemotherapy;Child;Childhood Osteosarcoma;chimeric antigen receptor;chimeric antigen receptor T cells;Client;Clinic;Clinical;Clinical Protocols;Clinical Trials;clinically relevant;comparative;cross reactivity;cytokine;cytotoxic;Cytotoxic Chemotherapy;Cytotoxic T-Lymphocytes;Data;design;Disease;Disease-Free Survival;Dose;Effectiveness;engineered T cells;Engineering;Engraftment;Exhibits;Flow Cytometry;Gene Expression Profiling;Generations;Genes;Genetic Engineering;Glioma;Glycolipids;graft versus host disease induction;graft vs host disease;Graft-Versus-Tumor Induction;Granzyme;Hematologic Neoplasms;Hematopoietic Neoplasms;Histopathology;Homing;Human;Immunocompetent;immunoregulation;Incidence;Infusion procedures;insight;irradiation;limb amputation;Maximum Tolerated Dose;Mediating;Metastatic Osteosarcoma;mouse model;Mus;nano-string;novel;novel strategies;Oncology;Osteosarcoma;Patient-Focused Outcomes;Patients;perforin;Peripheral Blood Mononuclear Cell;Phenotype;pre-clinical assessment;preclinical study;preconditioning;prevent;Publishing;Random Allocation;rare cancer;Refractory;Regimen;Relapse;response;Safety;safety assessment;Solid;Solid Neoplasm;Specificity;Supporting Cell;T cell therapy;T-Lymphocyte;Therapeutic Effect;Tissues;Toxic effect;transcriptomics;Treatment Efficacy;trial design;Tropism;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;tumorigenic;Whole-Body Irradiation;Work

PROJECT_TITLE: Advancing allogeneic CAR-iNKT for the treatment of solid tumors through comparative oncology


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: Project Narrative Heparin-induced thrombocytopenia (HIT) is the most common drug-induced disorder and can lead to catastrophic thrombosis in an affected patient. The proposed studies aim to identify and characterize the disease-causing B cells in the patients and may help to identify novel therapies for this potentially devastating disease.

PI_NAMEs: WANG, DEMIN  (contact)

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: Affect;Affinity;Alpha Granule;Antibodies;Antibody Formation;Antibody Response;antigen binding;ATAC-seq;Autoantibodies;B cell repertoire;B-Lymphocytes;Blood Platelets;Cells;Characteristics;Clonal Expansion;Color;comparison control;Complement 3d Receptors;complementarity-determining region 3;Complex;Development;Diagnosis;Disease;Disease Progression;disorder prevention;Epigenetic Process;epigenetic profiling;Evolution;Exhibits;Flow Cytometry;Future;Gene Expression Profiling;gene regulatory network;Genetic Transcription;Grant;Helper-Inducer T-Lymphocyte;Heparin;heparin-induced thrombocytopenia;Heterogeneity;High-Throughput RNA Sequencing;Human;Humoral Immunities;Idiopathic Thrombocytopenic Purpura;Immune response;Immune Tolerance;Immunoglobulin G;Immunologic Memory;indexing;insight;ITGAX gene;Mediating;Memory;Memory B-Lymphocyte;Molecular;mouse model;Mus;Nature;novel;novel therapeutics;Pathogenesis;Pathogenicity;Pathway interactions;Patients;PF4 Gene;Pharmaceutical Preparations;Phenotype;Plasmablast;platelet phenotype;Play;Prevention;Prevention strategy;Production;Proteins;Regulatory T-Lymphocyte;response;Role;Severities;Severity of illness;single-cell RNA sequencing;Sorting;Specificity;Structure of germinal center of lymph node;study characteristics;T-Lymphocyte;targeted treatment;Testing;Thrombosis;Trees

PROJECT_TITLE: B cell responses in heparin-induced thrombocytopenia

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CHAPEL HILL

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Lipidomic analyses provide a molecular understanding of biological and environmental perturbations; however, their measurements and identifications have lagged behind other techniques such as genomics and proteomics due to the broad chemical space and numerous isomers in the lipid categories. The planned research program will develop, evaluate and optimize a new platform and methods for greatly improved speciation and spatial location of lipid species in biological systems. These advanced techniques are expected to significantly improve the sensitivity and identification capabilities possible with current lipidomic technologies and eventually enable enhanced clinical assessments.

PI_NAMEs: BAKER, ERIN S (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;analytical method;Area;Biological;Biological Markers;Biological Models;Biological Process;biological systems;Cancerous;Categories;Cells;Characteristics;Chemicals;cheminformatics;Chromatography;Clinical assessments;Code;combinatorial;Complex;Computer software;Coupled;Data;Data Analyses;data analysis pipeline;data visualization;Derivation procedure;Detection;Development;Disease;disease diagnosis;Disease Progression;disorder prevention;Dissociation;Evaluation;experimental analysis;functional group;Gases;Genomics;Geometry;Goals;Head;Histology;improved;innovation;ion mobility;Ions;Isomerism;Length;Libraries;lipid structure;lipidomics;Lipids;Location;Marker Discovery;Mass Spectrum Analysis;Measurement;Methods;millisecond;Mission;Molecular;Molecular Analysis;National Institute of General Medical Sciences;Neoplasm Metastasis;novel;open data;Organ;Organelles;Outcome;Ozone;Phase;pi bond;Play;Positioning Attribute;programs;Protein Isoforms;Proteomics;Protocols documentation;Radial;Reaction;Research;Resolution;Role;Sampling;screening;Sensitivity and Specificity;Shotguns;Solid;Specificity;Specimen;Spectrometry;stereochemistry;System;Systems Biology;Techniques;Technology;Time;Tissues;Translating;user friendly software;Variant;Visualization;web app;Work

PROJECT_TITLE: Increasing the Coverage, Sensitivity and Specificity of Rapid Lipidomic Measurements

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Narrative Success of the proposed study will lead to an in-depth understanding of the molecular basis of ferroptosis and its interplay with cellular metabolism, and provide insights into the development of novel, mechanism-based cancer therapies.

PI_NAMEs: JIANG, XUEJUN  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Acyltransferase;Autophagocytosis;Binding;cancer cell;cancer invasiveness;cancer therapy;cancer type;CDH1 gene;Cell Death;Cell membrane;Cell Physiology;Cell Survival;Cells;Cessation of life;Citric Acid Cycle;clinically relevant;cohort;Communication;CRISPR-mediated transcriptional activation;Cytoprotection;Development;Disease;E-Cadherin;effective therapy;Endometrial Carcinoma;Energy Metabolism;Energy-Generating Resources;Enzymes;experimental study;Feedback;FRAP1 gene;Funding;Genetic;Genetic Annotation;genetic information;Genetic Transcription;Genetically Engineered Mouse;Goals;Grant;Homeostasis;insight;Iron;Ischemia;lipid biosynthesis;lipid metabolism;Lipid Peroxidation;lipidomics;Lipids;live cell imaging;Malignant neoplasm of liver;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Membrane;membrane activity;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Modification;Molecular;mouse model;Neoplasm Metastasis;Neurofibromin 2;novel;Oncogenic;organ injury;Organoids;overexpression;oxidation;Oxidation-Reduction;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathologic Processes;Pathway interactions;Patients;pharmacologic;Phospholipids;Physiological;PIK3CG gene;Predisposition;Process;Prognosis;Property;Proto-Oncogene Proteins c-akt;Regulation;Role;screening;Series;Signal Pathway;Signal Transduction;Stress;success;Testing;The Cancer Genome Atlas;Therapeutic;Tissues;Triglycerides;tumor;tumor metabolism;tumorigenesis;Validation;whole genome;Xenograft procedure

PROJECT_TITLE: Ferroptosis, Cellular Metabolism, and Cancer

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative (Overall) Acquired knowledge the tumor, its microenvironment, and the surrounding normal tissues has allowed us to identify innovative and unique means for normal tissue protection while enhancing tumor sensitivity to radiotherapy. At the same time, we augment the precision of these approaches by enriching for patients who would benefit from radiosensitization. This Program Project Grant focusses on widening the therapeutic index of radiotherapy through the activation of the Aldehyde Dehydrogenase 3A1 pathway in the treatment of head and neck cancers, the inhibition of the Complement C5aR1 pathway in the management gastrointestinal tumors, targeting KEAP1-mediated radioresistance in lung cancer, and inhibiting the Fat mass and obesity-associated protein (also known as alpha-ketoglutarate-dependent dioxygenase FTO) in cervical, lung and head and neck cancers.

PI_NAMEs: DIEHN, MAXIMILIAN ;LE, QUYNH-THU XUAN (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Abdomen;aldehyde dehydrogenases;alpha ketoglutarate;Animals;Artificial Intelligence;Biology;Cancer Cell Growth;Cancer Model;Cancer Patient;Cell Line;cell repository;Cervical;Clinic;Clinical;clinical care;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Complement;complement pathway;Data;Development;Dioxygenases;Doctor of Medicine;Doctor of Philosophy;Drug Targeting;Effectiveness;Epithelium;epitranscriptomics;Family;fat mass and obesity-associated protein;Feedback;Future;Gastrointestinal Neoplasms;Genomics;Glutaminase;Glutamine;Goals;Grant;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;image guided;improved;inhibitor;innovation;Ionizing radiation;Knowledge;Knowledge acquisition;Lead;limonene;Lung;Machine Learning;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;member;Metabolism;Molecular;mutant;Mutation;neoplastic cell;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;novel therapeutics;Nutraceutical;overexpression;Pathway interactions;Patients;personalized approach;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Phenotype;Program Research Project Grants;programs;Protein Inhibition;Radiation;radiation effect;Radiation induced damage;radiation mitigation;Radiation Protection;radiation resistance;radiation response;Radiation therapy;Radiation Tolerance;radioprotected;radioresistant;Radiosensitization;RNA;Role;Safety;Salivary;Salivary Glands;Serum;Solid Neoplasm;Specimen;stem cell survival;stem cells;Structure of parenchyma of lung;Techniques;Testing;Therapeutic Effect;Therapeutic Index;Time;Tissues;Toxic effect;Translating;treatment planning;tumor;Tumor Biology;Tumor Tissue;Work;Xerostomia

PROJECT_TITLE: Molecular Strategies to Widen the Therapeutic Index of Radiotherapy


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Radiation Oncology

PHR: Narrative (Project 1 - Oxford) The main focus of this proposal is to explore how inhibition of the complement pathway regulates the radiation response of tissues and tumors and our data show that targeting complement receptor C5aR1 improves radiation response in colorectal cancer models while reducing radiation-induced toxicity. No study has evaluated the effect of complement inhibition on both tumor and normal tissue radiation response. Our data, therefore, suggest that genetically or pharmacologically targeting C5aR1 can improve radiation response in colorectal tumor models while reducing radiation-induced small bowel toxicity, so together, these findings suggest that targeting complement could be a promising approach to increasing the therapeutic window of radiotherapy.

PI_NAMEs: GIACCIA, AMATO J. (contact)

PROJECT_TERMS: angiogenesis;Animal Model;antagonist;Apoptosis;Attenuated;Cancer Model;Cell Culture Techniques;cell killing;Cell Survival;Cells;Clinic;clinical effect;Collaborations;colon cancer cell line;Colorectal Cancer;Colorectal Neoplasms;Complement;complement pathway;Complement Receptor;complement system;crypt cell;Data;data sharing;Dependence;Disease;dosimetry;effectiveness evaluation;Ensure;Epithelium;Exhibits;gastrointestinal;gastrointestinal epithelium;gastrointestinal system;Gastrointestinal tract structure;Genetic;Histologic;Immune;Immunity;improved;In Vitro;in vivo;inhibitor;Interleukin-10;intestinal injury;Intestines;irradiation;Lung;Macrophage;Malignant Neoplasms;Mediating;Methods;Modeling;Molecular;molecular targeted therapies;Mus;Natural Immunity;neoplastic cell;Normal tissue morphology;Pathway interactions;pharmacologic;Phosphorylation;Population;Process;Proto-Oncogene Proteins c-akt;Radiation;Radiation induced damage;Radiation Protection;radiation response;Radiation therapy;Radiation-Sensitizing Agents;radioprotected;Radiosensitization;recruit;response;Role;Salivary Glands;Schedule;Signal Transduction;Site;Small Intestines;Stress;targeted treatment;Therapeutic;Therapeutic Index;Tissues;Toxic effect;TP53 gene;tumor;tumor progression;Tumor Promotion;Tumor Tissue

PROJECT_TITLE: Project 1: Inhibition of Complement C5aR1 Radioprotects Normal Tissue and Radiosensitizes Tumors


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Natural Products;Orphan Drug;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project Narrative Radiation-induced dry mouth is the most common side effect of head and neck cancer (HNC) treatment and it can lead to inability to eat a normal meal, recurring mouth infection, swallowing dysfunction and rare damage to the jawbone. We have previously found that adult salivary glands harbor stem/ progenitor cells (SSPCs) that express high level of an enzyme called ALDH3A1, and activation of this enzyme with d-limonene (a natural product compound) protects these cells from radiation damage without protection of cancer cells and improves saliva function after radiation. Therefore, we propose to conduct a small clinical trial to test the safety of d- limonene given with radiation and chemotherapy in HNC patients and to identify the maximum dose that is tolerable to these patients; at the same time we will also study its effect on protecting other normal tissues from radiation damage and collaborate with the other projects to develop novel ways to protect salivary glands and other tissues from radiation injury.

PI_NAMEs: LE, QUYNH-THU XUAN (contact)

PROJECT_TERMS: Address;Adult;aldehyde dehydrogenases;Aldehydes;Ames Assay;Apoptosis;bone;cancer cell;Cancer Patient;cancer radiation therapy;cancer therapy;carcinogenicity;cell killing;Cells;Chemopreventive Agent;chemoradiation;Chemotherapy and/or radiation;Chest;Clinic;clinical candidate;clinical translation;Clinical Trials;Collaborations;comparison group;Complication;cost;Cytoprotection;Data;Deglutition;Dental caries;Dermatitis;Dose;draining lymph node;Eating;Enzyme Activation;Enzymes;Epithelium;Esophageal mucous membrane;Esophagitis;European Organization for Research and Treatment of Cancer;follow-up;Functional disorder;Genes;Genetic;Gland;Glutaminase;Goals;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;implantation;improved;In Vitro;in vivo;Injections;instrument;Intensity-Modulated Radiotherapy;Intestinal Mucosa;irradiation;Knowledge;limonene;Location;Mass Fragmentography;Maximum Tolerated Dose;Measures;Mitochondria;Molecular;Morbidity - disease rate;Morphology;mouse model;Mucositis;Mus;mutant;Natural Products;Normal tissue morphology;novel;novel strategies;Oral;Oral Administration;oral infection;Oral mucous membrane structure;Outcome;Parotid Gland;Pathway interactions;Patient Outcomes Assessments;patient prognosis;Patients;Pharmaceutical Preparations;Phase;phase I trial;Plant Extracts;Plasma;Platinum;preservation;primary endpoint;Procedures;Production;Quality of life;Questionnaires;Radiation;Radiation induced damage;Radiation Injuries;Radiation Protection;Radiation therapy;Radiation Tolerance;radioprotected;Radiosensitization;Reactive Oxygen Species;Recurrence;Rest;Risk;Safety;safety testing;Saliva;saliva function;Salivary;Salivary Glands;side effect;Skin;small molecule;Statistical Data Interpretation;stem cell self renewal;stem cell survival;stem cells;Submandibular gland;Survivors;Terpenes;Testing;Therapeutic Index;Time;Tissues;Toxic effect;treatment duration;tumor growth;Work;Xenograft Model;Xenograft procedure;Xerostomia

PROJECT_TITLE: Project 2: ALDH3A1 Activation for Radioprotection of Salivary Glands and Other Head and Neck Epithelial Tissues


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The Medical Scientist Training Program (MSTP) at Yale proposes an integrated curriculum that teaches clinical medicine and provides experiential training in the design, execution and presentation of responsible, rigorous and reproducible research. The MSTP is committed to the recruitment and retention of a diverse and inclusive community of MD-PhD trainees in traditional and non-traditional PhD disciplines relevant to human health and disease. The inclusion of physician-scientist faculty from a range of clinical disciplines in the MSTP and a focus on career development training for students ensure that graduates will remain engaged in research-intensive careers that make full use of their dual-degree training.

PI_NAMEs: KAZMIERCZAK, BARBARA I (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Precision Medicine;Radiation Oncology

PHR: Project Narrative (Project 3) In this study we will test a precision radiation oncology approach for specifically radiosensitizing a radioresistant subset of non-small cell lung cancers. Our long-term objective is to develop personalized radiation sensitization strategies based on tumor genotypes that will broaden the therapeutic index of radiotherapy by maximizing cure rates and minimizing side effects.

PI_NAMEs: DIEHN, MAXIMILIAN  (contact)

PROJECT_TERMS: Anabolism;cancer imaging;Cancer Model;Cancer Patient;cell killing;Cell Line;cell type;Chest;Clinical;Clinical Trials;cohort;Collaborations;Complement Inactivators;Complement Receptor;Databases;Development;Dose;Esophagus;experimental study;Free Radicals;Future;Genetic Complementation Test;Genomics;Genotype;Glutaminase;Glutamine;Goals;Head and Neck Cancer;high risk;Human;improved;In Vitro;in vivo;inhibitor;irradiation;KRAS2 gene;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Molecular;molecular marker;Mus;Mutagenesis;mutant;Mutation;mutation screening;mutational status;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;Operative Surgical Procedures;Pathogenicity;Patient Selection;Patients;personalized strategies;personalized therapeutic;Play;predictive marker;protein function;Publishing;Radiation;radiation delivery;Radiation Oncology;radiation resistance;Radiation therapy;Radiation-Sensitizing Agents;radioresistant;Radiosensitization;Recurrence;Resistance;Role;side effect;System;Systemic Therapy;Techniques;Testing;Therapeutic Index;Toxic effect;Translating;tumor;Work

PROJECT_TITLE: Project 3: Targeting KEAP1-Mediated Radioresistance in Lung Cancer


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Lung;Lung Cancer;Orphan Drug;Radiation Oncology;Rare Diseases

PHR: Project Narrative (Project 4) The proposed research is relevant to the public health and the NIH mission to enhance the therapeutic index of radiation therapy. The proposed research has the potential to 1) identify a novel molecular target to radiosensitize tumors and enhance the therapeutic ratio of radiotherapy and 2) provide novel mechanistic insights into mechanisms by which epitranscriptomic modifications modulate the radiation response.

PI_NAMEs: RANKIN, ERINN B (contact)

PROJECT_TERMS: Acute;Adult;alpha ketoglutarate;analytical tool;antitumor effect;Apoptosis;biological adaptation to stress;Biological Assay;Bone Marrow;cancer cell;Cancer Cell Growth;Cell Survival;Cells;Cervical;Cervix Neoplasms;Collaborations;Data;DNA Repair;effective therapy;epitranscriptomics;Failure;fat mass and obesity-associated protein;gain of function;Genetic;Glutamine;Glutathione;Goals;Growth;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Human;improved;In Vitro;in vivo;innovation;insight;Intestines;Kidney;knock-down;Late Effects;Lung;lung cancer cell;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mission;Mitochondria;Modeling;Modification;Molecular;Molecular Target;Morbidity - disease rate;mortality;multidisciplinary;Mus;mutant;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;nucleotide metabolism;Oncogenic;Oral mucous membrane structure;overexpression;oxidative damage;Oxidative Stress;Pathway interactions;Patients;pharmacologic;pre-clinical;Public Health;Radiation;Radiation Dose Unit;radiation response;Radiation therapy;Radiation Tolerance;Radiation-Sensitizing Agents;Radiobiology;Radiosensitization;Renal Carcinoma;Research;response;RNA;Role;Safety;Salivary Glands;Signal Transduction;small molecule;Solid Neoplasm;stable isotope;standard care;Supplementation;targeted cancer therapy;Testing;Therapeutic;Therapeutic Index;therapeutic target;therapy outcome;therapy resistant;Toxic effect;transcriptome sequencing;Treatment Failure;tumor;tumor growth;Tumor Tissue;tumor xenograft;United States National Institutes of Health;uptake

PROJECT_TITLE: Project 4: FTO Inhibition to Enhance the Therapeutic Index of Radiotherapy


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: NARRATIVE Patients with advanced epithelial ovarian cancer (EOC) become resistant to platinum-based chemotherapies after which they have few treatment options and very short lifespan. The proposal clinically evaluates a newly developed chimeric antigen receptor (CAR) T cell therapy against EOC by redirecting the patients’ own immune T cells against the tumor target TAG72, which is highly expressed on the tumor cells. We have designed this potent immunotherapy to improve outcomes for patients with advanced EOC.

PI_NAMEs: PRICEMAN, SAUL ;RODRIGUEZ-RODRIGUEZ, LORNA  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Aftercare;Antigens;antitumor effect;Antitumor Response;Ascites;Breast;cancer biomarkers;cancer therapy;CAR T cell therapy;Catheters;Cells;Central Nervous System;Characteristics;chemotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Cities;Clinical;clinical candidate;clinical development;Clinical Research;clinical translation;Clinical Trials;cytokine;Data;design;Disease;Dose;effective therapy;engineered T cells;Epithelial ovarian cancer;Evolution;experience;first-in-human;Future;Gene Expression;Goals;Greater sac of peritoneum;Hematologic Neoplasms;human subject;Immune;Immune response;Immune system;Immunologic Monitoring;Immunologics;Immunotherapy;improved;improved outcome;Infiltration;Inflammatory;innovation;intraperitoneal;Intravenous;Investigational New Drug Application;Laboratories;Lead;life span;Light;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Maximum Tolerated Dose;Mediating;Medical;mouse model;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;overexpression;Pathway interactions;patient response;Patient-Focused Outcomes;Patients;peripheral blood;Peritoneal;Phase;phase 1 study;Phase I Clinical Trials;phase I trial;Phenotype;Platinum;Positioning Attribute;pre-clinical;preclinical study;preconditioning;Primary Brain Neoplasms;Prognosis;programs;Progression-Free Survivals;protein expression;Recommendation;Recurrence;Regimen;Relapse;Resistance;response;Route;Safety;safety and feasibility;Sampling;Site;Solid Neoplasm;success;Surface;Surface Antigens;systemic toxicity;T cell therapy;T-Cell Receptor Therapy;T-Lymphocyte;TAG-72 Antigen;Testing;Therapeutic;therapy resistant;timeline;trafficking;Translating;treatment response;tumor;tumor microenvironment;Work

PROJECT_TITLE: A Phase 1 Study to Evaluate Chimeric Antigen Receptor (CAR) T cells Targeting TAG72 in Patients with Recurrent Epithelial Ovarian Cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Genetics

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: PROJECT NARRATIVE Evidence suggests that dysregulations in the RNA modification landscapes strongly correlate with developmental deficiencies, learning and memory defects, and multiple diseases, including cancers. Research into understanding the fundamental biochemistry of RNA chemical modifications is essential to uncover how modifications play roles in physiology and diseases. We will develop methods that allow robust detection of chemical modifications in human cells, systematically study the sequence specificity in modifying RNA, and uncover how chemical modifications reshape RNA biology.

PI_NAMEs: ZHOU, HUIQING  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TITLE: INVESTIGATE SEQUENCE SPECIFICITY IN THE BIOSYNTHESIS AND RECOGNITION OF RNA CHEMICAL MODIFICATIONS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


NIH_SPENDING_CATS: Cancer;Radiation Oncology

PHR: Narrative (Core A) The success of a Program Project Grant involves statistical assistance, fiscal support, administrative management, and coordination between the projects and cores. In addition, the increased administrative requirements have driven the need for an administrative core. This core will work to ensure that all project and core leaders have adequate support and time to focus on their science.

PROJECT_TERMS: Administrator;Animals;Applications Grants;Area;Bioinformatics;Biometry;Biostatistics Core;Collaborations;Computer software;Data Analyses;Doctor of Philosophy;Ensure;Expenditure;experience;Goals;Grant;Human Resources;Infrastructure;Institution;Leadership;Malignant Neoplasms;meetings;member;Molecular;Monitor;National Cancer Institute;Office of Administrative Management;operation;Persons;Preparation;Principal Investigator;Program Research Project Grants;programs;Progress Reports;Protocols documentation;Publications;Radiation Oncology;Radiation therapy;Reagent;Regulation;Reporting;Research;Research Design;Research Personnel;Resource Allocation;Resources;Role;Science;success;Therapeutic;Therapeutic Index;Time;virtual;Work;Writing

PROJECT_TITLE: Administration Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Radiation Oncology

PHR: Project Narrative (Core B) Core B, the Translational Biology core of this program project, provides support to the projects for the execution of common methods including animal radiotherapy and histopathological analysis maintenance and for standardization of cell lines and shared resources. It is also responsible for development of improved methods for target identification and treatment planning to improve the accuracy and reproducibility of small animal irradiation. These are essential services that are common to all projects.

PI_NAMEs: GRAVES, EDWARD E. (contact)

PROJECT_TERMS: Algorithms;Animals;Artificial Intelligence;Biocompatible Materials;Biology;Board Certification;Caring;Cell Line;cell repository;Cell Therapy;Cells;Clinical;clinically relevant;Collaborations;Data;Data Set;design;Development;dosimetry;Ensure;experimental study;Film;Goals;Histopathology;Human Resources;Image;image guided;improved;Individual;Ions;irradiation;Laboratories;Machine Learning;Maintenance;Measures;Methodology;Methods;Modification;Molecular;Normal tissue morphology;novel;oncology trial;Pathologist;pre-clinical;programs;Radiation;Radiation Oncology;Radiation therapy;Radiobiology;Reagent;Reproducibility;Research;Resource Sharing;Resources;Sampling;Serum;Services;Site;Specimen;Standardization;technique development;Techniques;Therapeutic Index;Tissues;treatment planning;tumor;Tumor Tissue;X-Ray Computed Tomography

PROJECT_TITLE: Translational Biology Core


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Therapies for neurodevelopmental disorders (NDD) such as autism spectrum disorder and communication disorders are scarce because their causative cellular mechanisms are not well understood. We recently identified a worldwide population of individuals affected by NDDs caused by monogenic deletions in the ANKS1B gene. Our proposal to study patient-derived neurons and animal models of this newly identified genetic syndrome will help define causative mechanisms, identify biological targets for therapeutic intervention, and will yield broader insight into NDD etiology.

PI_NAMEs: JORDAN, BRYEN ALEXANDER (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Affect;Animal Model;autism spectrum disorder;Behavioral;behavioral outcome;Binding;Biochemical;Biological;Biological Assay;Brain;Brain Diseases;Cell model;Cell Nucleus;Cell Physiology;Clinical;Communication impairment;Complex;Disease;disorder risk;economic impact;Electrophysiology (science);Etiology;experimental study;Failure;Family member;Functional disorder;Gene Expression;gene function;Gene Mutation;Genes;Genetic;genetic risk factor;Genetic Screening;genetic signature;Genetic study;genome wide association study;genome-wide;Goals;Health;Heritability;Heterozygote;Human;Impairment;in vitro Model;in vivo;Individual;Induced pluripotent stem cell derived neurons;insight;Intervention;Laboratory Finding;Link;Mendelian disorder;Minor;Modeling;Molecular;Molecular Abnormality;Morphology;Motor;motor deficit;mouse model;N-Methyl-D-Aspartate Receptors;Neurodevelopmental Disorder;Neurons;novel;Nuclear;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphotransferases;Population;postsynaptic;Process;protein function;protein purification;Proteins;Proteomics;receptor function;Research;Rodent;Role;Single Nucleotide Polymorphism;Social Impacts;Speech;Synapses;synaptic function;Synaptic plasticity;Syndrome;SYNGAP1;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;transcriptomics;Transgenic Mice;ubiquitin-protein ligase;Uncertainty;Variant

PROJECT_TITLE: ANKS1B haploinsufficiency in a novel brain disorder


NIH_SPENDING_CATS: Cancer;Genetics;Skin Cancer

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative Malignant melanoma is an example of primary clinical significance for investigating sex hormones dependent differences in cancer in organs with non-reproductive functions. We will be exploring the interplay between androgen receptor and associated proteins in control of melanoma development and response to treatment.

PI_NAMEs: DOTTO, GIAN-PAOLO  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Address;Age;Androgen Receptor;Androgen Suppression;Androgens;AR gene;Biochemical;BRAF gene;cancer type;Cell Aging;Cells;clinically significant;Collection;Cytoplasm;Cytotoxic T-Lymphocytes;Data;Development;DNA;DNA Damage;DNA Repair;ds-DNA;Epigenetic Process;Estrogens;Extravasation;Female;Gene Expression Profile;Gene Silencing;Genes;Genetic;Genetic Transcription;genome integrity;Genome Stability;Gonadal Steroid Hormones;hormonal signals;Immunocompetent;in vivo;Incidence;Infiltration;Inflammatory;inhibitor;Lamin Type A;Lamins;Ligands;Link;Macrophage;Maintenance;male;Malignant Neoplasms;Melanoma;Melanoma Cell;Modeling;mouse model;Mutation;Nuclear Envelope;Nuclear Lamin;Nuclear Receptor Coactivator 4;Organ;overexpression;Pathway interactions;patient derived xenograft model;patient response;Patients;pharmacologic;Phosphorylation;Play;Population;Predisposition;prevent;Process;prognostic significance;Proliferating;Protein phosphatase;Proteins;receptor expression;receptor function;Receptor Inhibition;Receptor Signaling;Resistance;Resources;response;RNA Helicase;Role;self-renewal;sex;Sex Differences;sexual dimorphism;Signal Transduction;T-Cell Activation;Testing;transcriptomics;treatment response;tumor;tumorigenesis;Up-Regulation;Validation;women patients;Work

PROJECT_TITLE: Androgen receptor function in melanoma

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Immunotherapy;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE Understanding the tumor microenvironment (TME) heterogeneity and architecture are key to stratify cancer patients responsive to immunotherapy and clinical outcome. With the advent spatial transcriptomic (ST) technologies, computational tools are needed to decipher and make biological meaning out of the high- dimensional data produced from this technology. In the proposed research, we will tackle this challenge using statistical and computational methods that leverage the spatial information present in ST data in order to unlock the full potential of ST for understanding the TME.

PI_NAMEs: FRIDLEY, BROOKE L;YU, XIAOQING  (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: analytical method;analytical tool;Architecture;Automobile Driving;Basic Science;Bioconductor;Bioinformatics;Biological;Biological Assay;Cancer Center;Cancer Patient;Cancer Prognosis;Cancer Science;cancer therapy;cell type;Cells;Clinical;Clinical Sciences;Collaborations;Colorado;commercialization;Communication;Computer software;computerized tools;Computing Methodologies;Cytometry;Data;data integration;Data Scientist;data structure;design;Development;Ensure;Epigenetic Process;experimental study;falls;Future;Gene Expression;Genes;Genetic;Genomics;Goals;Heterogeneity;high dimensionality;Image;immune cell infiltrate;immune function;Immunofluorescence Immunologic;Immunotherapy;Individual;Infiltration;innovation;insight;interest;Location;Malignant Neoplasms;Manuscripts;Measurement;Measures;Methodology;Methods;Modality;multidimensional data;Mutation;Neoplasm Metastasis;novel;Outcome;patient response;Patients;personalized medicine;Pharmaceutical Preparations;Phenotype;phenotypic data;Process;prognostication;Research;Research Personnel;Research Project Grants;Resolution;response;RNA;Sampling;single-cell RNA sequencing;Slice;software development;Software Tools;spatial integration;Spottings;Statistical Methods;statistics;Technology;Tissue Fixation;Tissue Sample;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translating;Translational Research;treatment response;tumor;tumor heterogeneity;tumor microenvironment;tumorigenesis;Universities;usability;user friendly software;Visualization;web app;web based software

PROJECT_TITLE: Analytical tools for studying the tumor microenvironment leveraging spatial transcriptomics


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Overall Project Narrative PET Radiotracer and Translation Center (PET-RTRC) is a national resource that leverages the expertise of research groups throughout the country and in Europe to enhance the development and dissemination of novel PET radiotracers needed to transform biomedical research and advance human health.

PI_NAMEs: GROPLER, ROBERT J. (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Advisory Committees;Agreement;Area;Biological;Biology;Biomedical Engineering;biomedical imaging;Biomedical Research;Cell Physiology;Chemistry;Clinical;Collaborations;Communication;Communities;Country;COVID-19 pandemic;Data;data management;design;Development;Disease;Educational workshop;Europe;Evaluation;Fortification;Foundations;Funding;gamma-Chemokines;Grant;Health;Human;human disease;Hybrids;Image;Image Analysis;imaging facilities;improved;Individual;Inflammasome;Inflammation;Inflammation Process;Infrastructure;innovation;Intellectual Property;Investigational New Drug Application;Learning;lectures;Macrophage;member;Mitochondria;Molecular;monocyte;National Institute of Biomedical Imaging and Bioengineering;novel;novel diagnostics;novel therapeutics;operation;outreach;Performance;Positron-Emission Tomography;pre-clinical;precision medicine;preclinical imaging;preclinical study;Process;Production;programs;Protocols documentation;Published Comment;quantitative imaging;Radiology Specialty;radiotracer;Reactive Oxygen Species;receptor;Research;Resource Informatics;Resources;Schedule;Services;Site;Sphingosine-1-Phosphate Receptor;Standardization;Stress;success;Technology;technology research and development;technology training;trafficking;Training;training opportunity;Training Programs;Translations;Universities;Variant;Vision;Visit;Washington

PROJECT_TITLE: The PET Radiotracer Translation and Resource Center (PET-RTRC)


PHR: Administration Core Project Narrative Per the instructions in PAR-20-169, please see Overall Project Narrative.

PROJECT_TERMS: Advisory Committees;Biometry;Communication;Country;data management;Development;Ensure;Evaluation;Financial Support;Fortification;Funding;Goals;imaging capabilities;Infrastructure;innovation;Instruction;Legal patent;Licensing;Location;Medical Imaging;meetings;member;Movement;National Institute of Biomedical Imaging and Bioengineering;Occupational activity of managing finances;operation;Performance;Positron-Emission Tomography;preclinical imaging;programs;Progress Reports;quantitative imaging;radiotracer;Recommendation;Reporting;Research Personnel;Resource Informatics;Resources;Review Committee;Rotation;Scientist;Secure;Services;Site;Standardization;Technology;Tracer;Training;translational pipeline;Translations;Writing

PROJECT_TITLE: The PET Radiotracer Translation and Resource Center (PET-RTRC) Admin Core


ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The University of Iowa MSTP is committed to the goal of training outstanding students for careers as successful physician-scientists. We aspire to train individuals who will be leaders among the next generation of physician-scientists.

PI_NAMEs: BUCHANAN, GORDON F (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Urologic Diseases

PHR: TR&D 1 Project Narrative Per the instructions in PAR-20-169, please see Overall Project Narrative.

PI_NAMEs: TU, ZHUDE  (contact)

PROJECT_TERMS: Acute;Adhesions;Affinity;Animals;antagonist;Aorta;Astrocytes;Autoimmune Responses;Autoradiography;B-Cell Activation;Binding;Biodistribution;Biological;Biological Markers;Bladder Carcinoma;Bladder Neoplasm;bladder transitional cell carcinoma;Blood;Brain;brain endothelial cell;Brain imaging;cancer cell;cancer therapy;cell growth;Cell Survival;Cells;Characteristics;Chronic Kidney Failure;clinical investigation;CNS autoimmune disease;Collaborations;Communities;Control Animal;design;Development;Diabetes Mellitus;Disease;dosimetry;Drug Kinetics;Drug or chemical Tissue Distribution;Enzyme-Linked Immunosorbent Assay;Evaluation;Experimental Autoimmune Encephalomyelitis;Feedback;Fibrosis;first-in-human;Funding;Genetic Transcription;glial activation;Goals;High Pressure Liquid Chromatography;Human;human data;human disease;Image;imaging biomarker;imaging science;imaging study;Immune;immune cell infiltrate;Immunohistochemistry;ImmunoPET;In Vitro;in vivo;in vivo imaging;Infection;Infiltration;Inflammation;Inflammatory Bowel Diseases;inhibitor;innovation;Institution;Instruction;interest;Label;Ligands;Lymphocyte;Lymphoid Follicle;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Meningeal;Meninges;Messenger RNA;migration;Modeling;mRNA Expression;Multiple Sclerosis;Mus;Myeloid Cells;Names;neuroinflammation;nonhuman primate;novel;organizational structure;Plasma;Play;Positron-Emission Tomography;pre-clinical;Process;Protocols documentation;Publishing;Radiochemistry;Radiolabeled;radiotracer;Rattus;receptor;Recurrence;Relapse;Research;Resources;Rodent;Rodent Model;Role;Sampling;secondary lymphoid organ;Services;Signal Pathway;small molecule;Smooth Muscle Myocytes;Specificity;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Stains;Therapeutic;Tissue Sample;Tissues;Toxic effect;Tracer;Translations;tumor;uptake;Vascular Smooth Muscle;Western Blotting;Work

PROJECT_TITLE: Development of PET radiotracer for imaging sphingosine-1-phosphate receptor 2 (S1PR2)


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

PHR: Overall Project Narrative To provide a comprehensive understanding of cellular senescence, we propose leveraging our institutional expertise in senescence research, omics, high-resolution imaging, and informatics to establish the Washington University Senescence Tissue Mapping Center (WU-SN-TMC) within the NIH SenNet Research Network. WU- SN-TMC will examine dynamics and heterogeneity of senescence across four tissue types: bone marrow, breast, colon, and liver. The knowledge gained from this undertaking will enable researchers and clinicians to (1) more deeply understand homeostasis and (2) harness precision medicine to develop novel treatments for age-related diseases.

PI_NAMEs: CHEN, FENG ;DING, LI  (contact);FIELDS, RYAN C;STEWART, SHEILA A

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: 3-Dimensional;Age;age-related disease;Animal Model;animal model selection;Atlases;Automobile Driving;Basic Science;biobank;Bioinformatics;Biological Assay;Biological Markers;Bone Marrow;Breast;Cell Aging;Cell Culture Techniques;Cell Cycle Arrest;Cell model;Cell Physiology;Cellular biology;cellular imaging;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials Design;Collaborations;Collection;Colon;Comparative Study;Computer Models;computerized tools;Coupled;Data;Data Analyses;Data Coordinating Center;data sharing;Disease;Evaluation;experience;Funding;Genetic Transcription;Genome;Genomics;Goals;Heterogeneity;high resolution imaging;Homeostasis;Human;human disease;human tissue;Image;imaging platform;Imaging technology;Informatics;Infrastructure;insight;Institution;Investigation;Knowledge;life span;Light;Liver;Maps;medical schools;Medicine;member;Methods;Microscopy;molecular imaging;novel;Operative Surgical Procedures;Organ;Pathology;Patients;Phenotype;Physicians;Physiological;Positioning Attribute;precision medicine;Production;programs;proteogenomics;Proteomics;Ramp;Reporting;Reproducibility;Research;Research Personnel;Resolution;Resource Sharing;Sampling;Science;Scientist;senescence;senescent cell;sex;Signal Pathway;single cell sequencing;single molecule;Skin;Small Intestines;Specific qualifier value;Standardization;Stomach;Structure;synergism;Technology;technology development;Time;timeline;tissue mapping;Tissues;transcriptomics;Translational Research;United States National Institutes of Health;Universities;Validation;Visualization;Washington;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(70)R]


PI_NAMEs: DING, LI  (contact)

PROJECT_TERMS: Advisory Committees;Atlases;Biological;Biological Markers;Bone Marrow;Breast;Budgets;Cell Aging;Clinical;Collaborations;Colon;Communication;Companions;Data;Data Analyses;Data Coordinating Center;data sharing;Deposition;Development;Elements;Ensure;Environment;experience;Fostering;Foundations;Funding;Generations;Goals;Human;Image;Infrastructure;innovation;Institution;Leadership;Liver;Maps;meetings;member;Mission;Monitor;multidisciplinary;Oncology;operation;outreach;patient advocacy group;patient derived xenograft model;Patients;Pilot Projects;Positioning Attribute;Preparation;programs;Progress Reports;Proteomics;Quality Control;Recording of previous events;Records;repository;Research;Research Personnel;Resolution;Resources;Role;Scholarship;Science;senescence;Services;Site Visit;success;synergism;Technology;technology development;The Cancer Genome Atlas;timeline;Tissue atlas;tissue mapping;Tissues;Translating;tumor;United States National Institutes of Health;Universities;Washington;web site;Work

PROJECT_TITLE: WU-SN-TMC Admin Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Heart Disease;Hypertension;Neurosciences;Patient Safety;Prevention;Primary Health Care

ORG_CITY: SAINT AUGUSTINE

ORG_COUNTRY: TRINIDAD/TOBA

ORG_FIPS: TD

ORG_NAME: UNIVERSITY OF THE WEST INDIES

PHR: Project Narrative In the proposed study, a multidisciplinary team of investigators from Colombia, Jamaica, and the US will work with national and local government agencies and health systems to test the implementation and effectiveness outcomes of implementing and scaling up a team-based care strategy for hypertension control in Colombia and Jamaica. This study will identify effective, equitable, and sustainable strategies to achieve hypertension control in routine clinical settings and reduce cardiovascular risk in the general population of Latin America and the Caribbean, as well as other low- and middle-income countries.

PI_NAMEs: HE, JIANG ;LOPEZ-JARAMILLO, PATRICIO ;TULLOCH-REID, MARSHALL KERR (contact)

PROGRAM_OFFICER_NAME: BRUNO, FERNANDO PEREIRA

PROJECT_TERMS: Address;Adoption;Adult;Affect;Anti-Hypertensive Agents;Blood Pressure;blood pressure control;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Caribbean region;Cessation of life;Clinic;Clinical;Clinical Trials Data Monitoring Committees;Cluster randomized trial;cluster trial;Colombia;Communities;community advisory board;Community Health Aides;Control Groups;control trial;Cost Effectiveness Analysis;Data;Development;disability;Effectiveness;effectiveness outcome;Elements;Ensure;Equity;Evaluation;Evidence based intervention;Federal Government;follow-up;Follow-Up Studies;Funding;General Population;Geographic Locations;Goals;Government Agencies;Grant;group intervention;Health;Health system;High Prevalence;Home Blood Pressure Monitoring;Hypertension;hypertension control;hypertensive;implementation cost;implementation outcomes;implementation research;implementation strategy;Informed Consent;Institutional Review Boards;Intention;interest;Intervention;Intervention Trial;Interview;Jamaica;Knowledge;Latin America;Life Style;Local Government;low and middle-income countries;Maintenance;Manuals;Mediation;medication compliance;multidisciplinary;Needs Assessment;Nurses;Observational Study;Outcome Study;Patients;Penetrance;Pharmaceutical Preparations;Pharmacists;Phase;Physicians;Population;premature;primary care clinic;primary care setting;Procedures;Protocols documentation;Provider;Public Health;Random Allocation;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research Personnel;scale up;Self Management;Side;Supervision;Surveys;System;team-based care;Testing;Titrations;Training;treatment as usual;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Implementing and Scaling Up a Team-based Care Strategy for Hypertension Control in Colombia and Jamaica


PI_NAMEs: FIELDS, RYAN C (contact)

PROJECT_TERMS: Age;age group;Aging;Atlases;Back;Bioinformatics;Biological;Biopsy;Bone Marrow;Breast;breast surgery;Cell Aging;chemotherapy;Chemotherapy-Oncologic Procedure;Chronic Disease;Clinical;Clinical Data;Clinical Research;cohort;Cohort Studies;Collaborations;Collection;Colon;Comparative Study;Complex;Cosmetics;Data;design;Dimensions;Disease;Endoscopy;Enrollment;Ensure;Evaluation;follow-up;gastrointestinal;Gastrointestinal Surgical Procedures;Goals;Health;Heterogeneity;Human;human tissue;Image;Individual;individual patient;Infrastructure;Investigation;life span;Liver;Malignant Neoplasms;Maps;Metadata;multiple omics;Mus;Operative Surgical Procedures;Participant;Pathologist;patient population;Patient Recruitments;Patients;Phenotype;Prior Chemotherapy;Procedures;programs;prospective;Protocols documentation;Research;Research Infrastructure;Resolution;Sampling;senescence;Skin;Skin Tissue;Small Intestines;Source;Specimen;Stomach;Structure;success;Surgeon;System;Testing;Time;time use;Tissue Banks;tissue mapping;Tissues;Translational Research;translational scientist;tumor;Universities;Washington

PROJECT_TITLE: WU-SN-TMC Biospecimen Core


PHR: TR&D 2 Project Narrative Per the instructions in PAR-20-169, please see Overall Project Narrative.

PI_NAMEs: LIU, YONGJIAN  (contact)

PROJECT_TERMS: Affinity;Animal Model;Anti-Inflammatory Agents;Automobile Driving;beta-Chemokines;Binding;Biological Markers;Bone Marrow;Categories;Cell Surface Proteins;Cells;chemokine;chemokine receptor;Classification;Clinical Research;Cues;cytokine;Data;design;Detection;Development;Disease;Disease Progression;Drug Kinetics;Embryo;Ensure;Environment;Epigenetic Process;Evaluation;Fetal Liver;fibrotic lung;functional plasticity;Goals;Grant;Hematopoietic;Heterogeneity;Homeostasis;Host Defense;Human;human tissue;idiopathic pulmonary fibrosis;Image;Image Enhancement;Imaging Device;Immune;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;Innate Immune System;Instruction;Leukocytes;Libraries;Ligands;Macrophage;Macrophage Activation;Maintenance;Malignant - descriptor;Malignant Neoplasms;Membrane;Metabolic;monocyte;Morphogenesis;Mus;Natural Immunity;non-invasive imaging;novel;Organ;pathogen;Pathologic;Patients;Peptides;Phage Display;Phagocytes;Phenotype;Population;Positron-Emission Tomography;Production;Proliferating;Publishing;radiotracer;Reaction;recruit;Regulation;repaired;Research;Resolution;Resources;response;risk stratification;Role;scavenger receptor;Sensitivity and Specificity;Services;Shapes;Signal Transduction;small molecule;Spatial Distribution;specific biomarkers;Specific qualifier value;Specificity;Specimen;Surface;Testing;tissue injury;tissue repair;Tissues;Tracer;Translations;Tumor-associated macrophages;Variant;Visualization;Work;Yolk Sac

PROJECT_TITLE: Imaging macrophage subset dynamics in inflammation


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Narrative Cardiotoxicity (CTX), a side effect of breast cancer treatments such as anthracycline chemotherapy and human epidermal receptor-2 (HER-2) targeted therapies, is more prevalent in Black breast cancer survivors than in White breast cancer survivors; however, causes of this racial disparity are not fully understood. This study will leverage hospital data and will interview breast cancer survivors diagnosed with CTX to inform a survey that will aid in the identification of drivers of the racial disparity in CTX, namely, psychosocial and socio-cultural factors that have been explored in the cardiovascular literature but are novel to the cardio-oncology space. Findings from this study may offer opportunities to develop multilevel interventions seeking to improve outcomes in Black breast cancer survivors by addressing the racial disparity in CTX.

PI_NAMEs: SUTTON, ARNETHEA LA'SHAUN (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Address;Adjuvant Therapy;Adrenergic beta-Antagonists;Advisory Committees;Age;Anthracycline;Anxiety;Attention;Award;Behavioral;Black race;black women;Breast Cancer Patient;breast cancer survival;Breast Cancer survivor;Breast Cancer Treatment;cancer care;cancer health disparity;Cardiac;Cardiac health;Cardiology;Cardiotoxicity;Cardiovascular Diseases;Cardiovascular system;care delivery;care outcomes;Caring;Cause of Death;chemotherapy;Chronology;Clinical;comorbidity;Computerized Medical Record;Coupled;Data;Death Rate;Demographic Factors;Development;Diagnosis;Disparity;disparity gap;Disparity in diagnosis;Doxorubicin;early onset;Electronics;Ensure;Environment;Epidermal Growth Factor Receptor;experience;Female;Goals;Healthcare;Heart;Heart Diseases;Heart failure;high body mass index;High Prevalence;Hospitals;Human;human old age (65+);improved;improved outcome;insight;Institution;Intervention;Interview;Learning;Left Ventricular Dysfunction;Life;Literature;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Medical;Medical Records;Mentors;Modeling;mortality;Myocardial dysfunction;National Cancer Institute;novel;Oncology;Pathway interactions;Patients;Pattern;perceived discrimination;Phase;Prevalence;prevent;primary outcome;programs;Prospective, cohort study;psychological distress;psychosocial;Psychosocial Factor;Race;racial difference;racial disparity;receptor;recruit;Reporting;Research;Research Methodology;Research Project Grants;Resources;Risk;Risk Factors;Role;secondary outcome;side effect;Smoking;social;social culture;sociocultural determinant;sociodemographics;Strategic Planning;success;Surveys;Survivors;survivorship;targeted treatment;therapy development;Training;Treatment-Related Cancer;White Women;Woman;Women's mortality;women's treatment

PROJECT_TITLE: Unpacking the Multi-level Drivers of Cardiotoxicity Disparities in Breast Cancer Survivors

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Pneumonia;Pneumonia and Influenza;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: GALVESTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE An increasing number of global deadly plague cases, including within the U.S., highlights the importance of studying new virulence genes of this pathogen and to develop safe plague vaccines, especially because antibiotic-resistant Yersinia pestis strains exist in nature or have been developed for bioweaponization. Based on the identification of new virulence genes, we have developed two excellent vaccine candidates which trigger robust protective humoral and cellular immune responses in rodents. The immunological basis of protection as well as long-term efficacy of the vaccine(s) will now be tested in nonhuman primates before launching final preclinical toxicology studies.

PI_NAMEs: CHOPRA, ASHOK K (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Acyltransferase;African Green Monkey;Animals;Antibiotic Resistance;Antibodies;Antibody Formation;Antibody Response;Antibody titer measurement;Antigens;arm;Attenuated;Attenuated Vaccines;Bacteria;Bacterial Antigens;Binding;bioweapon;Bite;Bubonic Plague;Calcium;Case Fatality Rates;Categories;Cells;Cellular Immunity;Cessation of life;China;climate change;Clinical;Clinical Research;Clinical Trials;co-infection;combat;Congo;Coronavirus;Country;cytokine;Data;Democratic Republic of the Congo;Disease;Disease Outbreaks;Dose;emerging human pathogen;Engineering;Etiology;Exclusion;Exposure to;Fatality rate;FDA approved;Fleas;Fright;Future;Gene Deletion;Generations;Genes;Genetic Engineering;Goals;Human;IL17 gene;Immune response;Immunity;Immunization;Immunize;immunogenicity;Immunoglobulin A;Immunoglobulin G;Immunologics;Infection;Injections;innovation;Interferon Type II;Intramuscular;Invaded;Iron Overload;Laboratories;Lauric Acids;Left;Legal patent;Lesion;Licensing;Link;Lipopolysaccharides;Lipoproteins;Macaca;Macaca fascicularis;Madagascar;Military Personnel;Modeling;mouse model;Mucosal Immunity;Mus;mutant;Nature;Nepal;Neutrophil Infiltration;nonhuman primate;novel;novel coronavirus;pandemic disease;pathogen;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Plague;Plague Vaccine;Plasminogen Activator;Pneumonic Plague;pre-clinical;Quarantine;rational design;Rattus;Reporting;Resistance;resistant strain;respiratory;response;Rodent;Rodent Model;Role;Serum;Signal Transduction;Site;Subunit Vaccines;Symptoms;T cell response;Testing;Th1 Cells;TLR2 gene;TLR4 gene;Toxicology;translational approach;Type III Secretion System Pathway;Vaccinated;vaccine access;vaccine candidate;Vaccine Design;vaccine efficacy;Vaccines;Variant;Virulence;virulence gene;Yersinia pestis;Zoonoses

PROJECT_TITLE: Immunological characterization of rationally-designed vaccines against plague in mice and non-human primate models

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Clinical Research;Data Science;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Age;age group;Analysis of Variance;analytical tool;Anatomy;Atlases;Back;Biological;Biological Assay;Bone Marrow;Breast;Breeding;Categories;Cell Aging;Chromatin;Colon;Communities;computerized data processing;computerized tools;Data;Data Analyses;data analysis pipeline;Data Commons;Data Coordinating Center;data format;data harmonization;data integration;data management;data modalities;data sharing;data standards;data warehouse;demographics;Development;Dimensions;DNA;Evolution;experience;FAIR principles;Generations;Genome;Goals;Heterogeneity;Image;Imaging Techniques;Imaging technology;Individual;Informatics;insight;Intake;interoperability;large scale data;Licensing;Light;Link;Liver;Machine Learning;Maps;Metadata;Methods;Microscopy;Mission;Modeling;Molecular;Oncogenes;open data;open source;Organ;Philosophy;Population;Procedures;Process;process improvement;programs;Property;Proteomics;public database;Publishing;Recording of previous events;Research;Research Infrastructure;Running;senescence;senescent cell;single nucleus RNA-sequencing;Specimen;statistics;success;System;Technology;The Cancer Genome Atlas;Time;tissue mapping;Tissues;tool;transcriptome sequencing;transcriptomics;Tumor Suppressor Proteins;Universities;user-friendly;Visualization software;Washington

PROJECT_TITLE: WU-SN-TMC Data Analysis Core


NIH_SPENDING_CATS: Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative Methods capable of defining protein complex dynamics directly in living systems hold tremendous promise for defining the molecular mechanisms that underly normal and disease signaling. Here we propose to develop and validate several complementary light-dependent proximity profiling platforms capable of detecting protein interaction dynamics in live cells with high spatial and temporal resolution, as well as minimal perturbation to the cellular environment. Application of these platforms to map the protein social network remodeling in response to dysregulated cellular metabolism and redox regulation will provide an unparalleled view of disease signaling, as well as serve as a blueprint for future studies of other dynamic signaling pathways with photoproximity platforms.

PI_NAMEs: MOELLERING, RAYMOND E (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Aging;analysis pipeline;Antioxidants;Architecture;Benchmarking;Biological;biological adaptation to stress;Biological Assay;Biology;Cells;Cellular Stress;Cellular Structures;Cementation;Characteristics;Chemicals;Communities;Data;Data Set;Degenerative Disorder;Development;Disease;Environment;Event;Future;Genetic Transcription;Goals;Grant;Homeostasis;In Situ;In Vitro;interest;Intervention;Investments;Kinetics;Label;Light;Macromolecular Complexes;Malignant Neoplasms;Maps;Mediating;member;Metabolic;Metabolic stress;Metabolism;Methods;Molecular;nanoscale;Nature;Neurodegenerative Disorders;next generation;novel;Organism;Oxidation-Reduction;Pathway interactions;Performance;Positioning Attribute;preference;programs;Property;protein complex;Protein Dynamics;Proteins;Proteomics;Publishing;Radial;Regulation;Research;Resolution;response;sensor;Signal Pathway;Signal Transduction;Social Network;Stress;System;technology platform;temporal measurement;Testing;Therapeutic Intervention;tool;transcription factor;Translating;Vertebral column;Work

PROJECT_TITLE: Mapping Protein Social Network Dynamics with Photoproximity Profiling Platforms

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Aging;Bioengineering;Biomedical Imaging;Biotechnology;Lung;Neurodegenerative;Neurosciences;Rare Diseases

PHR: TR&D 3 Project Narrative Per the instructions in PAR-20-169, please see Overall Project Narrative.

PI_NAMEs: SHARMA, VIJAY  (contact)

PROJECT_TERMS: A549;Acute Lung Injury;Acute Respiratory Distress Syndrome;Advisory Committees;Aging;Agreement;Alzheimer's Disease;analog;Animal Model;Asthma;Atherosclerosis;Bacterial exotoxin;Biochemical;Biological Assay;biomedical imaging;Blood - brain barrier anatomy;Blood Vessels;Brain;Cardiovascular Diseases;Cardiovascular system;Cells;Cellular Assay;Central Nervous System Diseases;Characteristics;Chemoresistance;Clinic;Compensation;Copper;Cysteine Desulfhydrase;Data;design;Detection;Diabetes Mellitus;Diameter;Disease;DNA;dosimetry;Drug Kinetics;Epithelium;Fluorescence;Fluorescent Probes;Fluorine;Free Radicals;Functional Imaging;Functional impairment;Funding;Future;Gallium;Gastrointestinal tract structure;Generations;Genetic Transcription;Grant;Homeostasis;Human;Hydrogen Peroxide;Hydroxyl Radical;Image;imaging capabilities;imaging probe;in vivo;Inflammation;inhibitor;Injury to Kidney;Instruction;Investigation;Ischemia;ITGB3 gene;Lead;Link;Lipids;Location;Lung;Lung Transplantation;Malignant Breast Neoplasm;Mediating;Meningeal;Metastatic Neoplasm to the Bone;Mitochondria;Modeling;molecular imaging;Monitor;Multiple Sclerosis;muscle physiology;Nephrotic Syndrome;Neurodegenerative Disorders;nonhuman primate;Oncology;Optics;Oxidants;Oxidation-Reduction;Oxidative Stress;Oxygen;Parkinson Disease;pathogen;Pathogenesis;Performance;Pharmacodynamics;Physiological;Positron;Positron-Emission Tomography;Production;programs;Proteins;Psoriasis;Radioisotopes;radiotracer;rational design;Reactive Oxygen Species;Recommendation;Reporter;Resources;Rheumatoid Arthritis;Rodent;Rodent Diseases;Rodent Model;Safety;scaffold;Science;Services;Signal Transduction;Skeletal Muscle;Superoxides;System;systemic inflammatory response;Tissues;Tracer;trait;Translations;transplant model;uptake;Validation;Vascular remodeling

PROJECT_TITLE: PET Tracers for Imaging ROS Activity


PI_NAMEs: CHEN, FENG  (contact)

PROJECT_TERMS: 3-Dimensional;Age;age related;Architecture;ATAC-seq;Atlases;Basic Science;Behavior;Biological;Biological Markers;biomarker identification;biomarker signature;biomarker validation;Body System;Bone Marrow;Breast;Cell Aging;cell type;Cells;Characteristics;Clinical;Colon;Complex;Data;Data Analyses;detection method;Dimensions;Disease;Emerging Technologies;Environment;Epigenetic Process;exome sequencing;experience;Fluorescence Microscopy;Gene Expression Profile;Generations;Genes;Genetically Engineered Mouse;Goals;Human;human disease;human tissue;Image;improved;Individual;Infrastructure;life span;Light;Liver;Machine Learning;Maps;Methods;Microscopy;model organism;Molecular;mouse model;multiple omics;new technology;Normal tissue morphology;novel strategies;novel therapeutics;Operative Surgical Procedures;Organ;Phenotype;Physiological;Positioning Attribute;Proteomics;Protocols documentation;Research;Resolution;Sampling;scale up;senescence;senescence associated secretory phenotype;senescent cell;sex variable;Site;Small Nuclear RNA;Spatial Distribution;Specificity;Specimen;Standardization;Stimulus;synergism;Technology;technology platform;Testing;therapeutic target;Time;Tissue atlas;tissue mapping;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;tumor;Universities;Washington;Work

PROJECT_TITLE: WU-SN-TMC Bio-Analysis Core