ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Effective messaging to counter misinformation and encourage healthy behaviors, including COVID-19 vaccination, must accommodate differences in preferences, habits, and behaviors across minority populations experiencing health disparities. This proposal aims to build a computational framework to measure heterogeneity in information exposure and engagement during COVID-19; to model the predictors of highly engaging and persuasive messages (including sources, linguistic choices, and content); and investigate the response to social media misinformation through pragmatic qualitative methods to counter misinformation and promote healthy behaviors. While we focus our proposal on COVID-19 vaccination and compare misinformation exposure and attitudes based on race (Black and white) and urban vs. rural populations; the approach is adaptable and will establish a nimble and responsive paradigm for precision public health messaging beyond COVID-19.

PI_NAMEs: GUNTUKU, SHARATH CHANDRA  (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Address;American;Attitude;Behavior;Black American;Black Populations;Black race;caucasian American;Characteristics;Chronic Disease;combat;Communities;Computer Analysis;computer framework;computerized tools;Confusion;Consent;Consumption;County;COVID-19;COVID-19 impact;COVID-19 misinformation;COVID-19 pandemic;COVID-19 vaccination;current pandemic;Data;Data Set;Decision Making;design;Development;disparities in morbidity;Disparity;Distress;distrust;Economics;Emergency Situation;Equity;experience;Facebook;flexibility;Future;Generations;Goals;Habits;Health;Health behavior;Health Campaign;health communication;Health Disparities Research;health disparity;health equity;Healthcare;Heterogeneity;HIV;HIV vaccine;Human;Individual;individual response;Inequity;infodemic;insight;Institution;Interview;Knowledge;Language;lens;Linguistics;Location;Longitudinal cohort;Machine Learning;machine learning model;Malignant Neoplasms;Masks;Maternal Mortality;Measures;media use;Medicine;Mental Health;Methods;Minority Groups;Misinformation;mortality;National Institute on Minority Health and Health Disparities;Natural Language Processing;Noise;novel;Outcome;pandemic disease;patient oriented;Patients;Perception;Persuasive Communication;Politics;population health;Predictive Analytics;predictive modeling;preference;Process;prospective;Public Health;Published Comment;Qualitative Methods;Race;racial disparity;racial diversity;rapid technique;recruit;response;Risk;Rural;rural Americans;rural area;Rural Community;rural dwellers;Rural Population;Sampling;Signal Transduction;social;Social Distance;social media;Source;Structural Racism;Structure;support tools;Surveys;synergism;Target Populations;Testing;Text;theories;Training;Translating;Trust;Twitter;urban area;Urbanicity;Vaccination;Variant

PROJECT_TITLE: Investigating and identifying the heterogeneity in COVID-19 misinformation exposure on social media among Black and Rural communities to inform precision public health messaging


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative The Mount Sinai Health and Environment Across the LifeSpan P30 Core Center: (1) supports state-of-the-art research infrastructure to discover the environmental causes of disease and disability across the lifespan, (2) translates scientific discoveries into new, evidence-based strategies for disease prevention and treatment, and (3) builds the careers of young physicians and scientists dedicated to environmental health research.

PI_NAMEs: WRIGHT, ROBERT O (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Acceleration;Address;Aging;analytical method;Applications Grants;Area;autism spectrum disorder;Award;base;Big Data;Big Data Methods;Bioinformatics;Biological;Biological Markers;Biology;Biometry;built environment;career;career development;Chemical Exposure;Child;Child Health;Circadian Rhythms;Clinical;Clinical and Translational Science Awards;clinical care;cohort;Collaborations;Communication;Communities;community engagement;Complex;computer infrastructure;Core Facility;Data;Data Analyses;Data Analytics;Data Science;Dedications;Development;developmental disease;disability;Disease;disorder prevention;disorder risk;Doctor of Philosophy;electronic health data;Environment;environmental chemical exposure;Environmental Exposure;Environmental Health;environmental justice;Epidemiologist;evidence base;experience;exposure pathway;Faculty;Feedback;Funding;Goals;Grant;Growth;Health;health disparity;Health equity research;health science research;Health Sciences;Human;Human Resources;Immunology;Individual;Infrastructure;innovation;Institution;instrument;Investments;K-Series Research Career Programs;Laboratories;Lead;Letters;Life;Life Cycle Stages;life span;Light;Link;Malignant Neoplasms;Measures;medical schools;member;Mentored Clinical Scientist Development Program;Methods;Mission;Molecular Epidemiology;Names;National Institute of Environmental Health Sciences;Nature;novel;nutrition;Outcome;Pediatrics;Periodicity;Phenotype;phenotypic data;Philosophy;Physicians;Pilot Projects;Play;pollutant;Population;Positioning Attribute;Precision Medicine Initiative;Predisposition;prevent;programs;Publications;Recommendation;recruit;Research;Research Infrastructure;Research Personnel;Resources;response;Role;SARS-CoV-2 infection;Science;Scientist;Services;Skin;Social Environment;Statistical Methods;Stress;success;Sum;Time;Trace Elements;Training;Translating;Translations;United States National Institutes of Health;Universities;Update;wearable device

PROJECT_TITLE: Mount Sinai Center for Health and Environment Across the LifeSpan (HEALS)

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(P)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

PROJECT_TERMS: Acceleration;Aging;analytical method;anti-racism;Applications Grants;Award;Back;base;Biological Markers;Biology;Biometry;career;career development;Cartoons;Child;Cities;Clinical;clinical phenotype;Collaborations;Communication;Communities;community based participatory research;community based research;community engagement;community partners;Core Facility;Counseling;Data;Data Analyses;Data Science;Dermatology;Disease;diversity and equity;Educational workshop;Effectiveness;Endocrine system;Ensure;Environment;Environmental Health;environmental justice;Environmental Risk Factor;Equipment;equity, diversity, and inclusion;Evaluation;Extramural Activities;Faculty;Fostering;Funding;Goals;Grant;Health;health science research;Health Sciences;Hispanic-serving Institution;improved;indexing;Infrastructure;Institution;instrument;inter-institutional;Investments;Journals;Justice;Laboratories;Lead;Leadership;Letters;Life Cycle Stages;life span;Malignant Neoplasms;Measures;medical schools;Medicine;meetings;member;Mission;Modeling;National Institute of Environmental Health Sciences;neurobehavioral;New York;Paper;Peer Review;Persons;Phenotype;Physiological;Pilot Projects;Policies;population health;Prevention strategy;Productivity;Program Development;programs;Progress Reports;Public Health Practice;Publications;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resources;respiratory;Role;Science;Scientist;Services;Sleep;social media;Social Responsibility;social stress;Structure;success;Toxicology;Training;Translating;Twitter;United States National Institutes of Health;Universities;user-friendly

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ORANGEBURG

ORG_NAME: NATHAN S. KLINE INSTITUTE FOR PSYCH RES

PHR: PROJECT NARRATIVE  This project aims to enhance our understanding of the role of the CA2 region of the hippocampus in different forms of epilepsy, further validating CA2 as a novel target for treating seizure disorders. We previously found that genetic-based manipulations that silence a portion of CA2 (dorsal CA2) reduce the frequency and duration of seizures in a mouse model of temporal lobe epilepsy (TLE). Here we aim to improve on our ability to treat seizures by silencing a different region of CA2 (ventral CA2) strongly implicated in seizure activity in humans, and by examining the role of CA2 in a genetic mouse model of epilepsy.

PI_NAMEs: SCHARFMAN, HELEN E (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acute;Address;Anatomy;Animal Model;Area;Cations;Characteristics;Chronic;dentate gyrus;Development;Dorsal;Drug resistance;Epilepsy;epileptic encephalopathies;experimental study;Frequencies;functional restoration;Funding;Genes;Genetic;Genetic Models;genetic variant;Goals;HCN1 channel;HCN1 gene;hippocampal pyramidal neuron;Hippocampus;Human;human model;improved;in vivo;Intervention;Intractable Epilepsy;Ion Channel Gating;kainate;Left;Memory;Modeling;Molecular;mouse model;Mus;Mutation;Nerve Degeneration;new therapeutic target;novel;novel therapeutic intervention;optogenetics;Patients;Pattern;Pilocarpine;Play;Potassium Channel;potassium channel protein TREK-1;pre-clinical;Property;Public Health;response;Rodent;Rodent Model;Role;Sclerosis;Seizures;selective expression;Site;Slice;social;Source;Status Epilepticus;Synapses;synaptic inhibition;Temporal Lobe Epilepsy;Testing;Therapeutic;therapeutic target;Tonic - clonic seizures;Up-Regulation;Variant;voltage

PROJECT_TITLE: The Role of Hippocampal area CA2 in Epilepsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Aging;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ARORA, MANISH  (contact)

PROJECT_TERMS: Acceleration;Address;Adolescence;Adopted;Air Pollution;Analytical Chemistry;base;Big Data;biobank;Biological;Biological Assay;Biological Markers;biological specimen archives;Center for Translational Science Activities;Chemicals;Chronic Disease;Clinic;Clinical;Clinical and Translational Science Awards;Clinical Medicine;Clinical Research;cohort;Collaborations;community engagement;community partners;Complex;Consultations;Core Facility;Counseling;critical period;Data;design;Disease Progression;DNA Sequencing Facility;Dose;early childhood;Educational workshop;Elderly;Ensure;Environment;Environmental Exposure;Environmental Health;environmental justice;Environmental Risk Factor;Epidemiology;Epigenetic Process;equity, diversity, and inclusion;Exposure to;Faculty Recruitment;Financial Support;Fostering;Funding;Goals;Grant;Growth;Hair;Health;health inequalities;health science research;Health Sciences;Health system;Human;Human Development;Individual;infancy;innovation;insight;Institution;International;Laboratories;Lead;Life;Life Cycle Stages;life span;Link;Measures;member;Methods;middle age;Mission;Mitochondria;Modeling;molecular marker;National Institute of Environmental Health Sciences;new technology;novel;patient response;Patients;Phenotype;Pilot Projects;Play;Population;Predisposition;Pregnancy;programs;Progress Reports;Publications;remote sensing;Research;Research Design;Research Personnel;research study;Resolution;Resources;response;response biomarker;Role;Science;Scientist;Services;study population;success;Technology;Temperature Sense;Testing;Tooth structure;Toxic Environmental Substances;Toxicology;Translational Research;Translations;treatment response;United States National Institutes of Health;Update;ward;Weather;Work

PROJECT_TITLE: Integrated Health Sciences Facility Core


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Little is known about the effects of the physical, social and built environments on risks for stillbirth. Minority and low-income populations are differentially exposed to ambient air pollution and other neighborhood-level stressors and suffer what has been termed “double jeopardy.” The overall objective of the proposed study is to evaluate the impact of source-specific exposures to multiple air pollutants using innovative Bayesian spatial multivariate receptor models, neighborhood deprivation and residential greenness on stillbirth, and to evaluate effect modification due to race/ethnicity.

PI_NAMEs: PARK, EUN SUG ;SYMANSKI, ELAINE  (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Accounting;Address;Adverse effects;Air Pollutants;Air Pollution;ambient air pollution;Awareness;Bayesian Modeling;built environment;Categories;Cities;Complex Mixtures;County;Data;deprivation;disorder risk;Disparity;disparity reduction;Dust;Environmental Exposure;ethnic disparity;Ethnic Origin;Exposure to;Fetal Death;Fetal Growth Retardation;fine particles;Future;Genetic;Health;health disparity;Health Priorities;Individual;innovation;Intervention;Investigation;land use;Location;Low Birth Weight Infant;Low Income Population;Maps;Maternal and Child Health;Measurement;Metals;Meteorology;Methods;Minority;Mission;Modeling;Modification;National Institute of Environmental Health Sciences;Nature;neighborhood disadvantage;Neighborhoods;obstetric outcomes;Outcome;Ozone;particle;Particulate Matter;Physical environment;Play;pollutant;Pollution;Population;Predisposition;Pregnancy;Pregnant Women;Premature Birth;Public Health;Race;racial disparity;receptor;Reporting;Risk;Role;Social Environment;Source;stillbirth;stressor;Surface;Texas;Time;Uncertainty;United States National Institutes of Health;Woman

PROJECT_TITLE: Source-specific multi-pollutant exposures and the neighborhood context in disparities in stillbirth

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The discovery of new and effective treatments for cardiovascular diseases requires the identification of novel disease mechanisms. This proposal aims to enhance our mechanistic insights of vascular calcification by focusing on the activation of autophagy pathway to prevent the development of artery calcification in humans. Success in identifying the specific molecules in this pathway implicated in the development of calcification will provide new targets for treatment of peripheral arterial disease.

PI_NAMEs: LINO CARDENAS, CHRISTIAN LACKS (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Acceleration;acute coronary syndrome;Adult;advanced disease;Advisory Committees;Affect;Aorta;Arteries;ATAC-seq;Atherosclerosis;Autophagocytosis;Autophagosome;Award;Blood Vessels;calcification;Calciphylaxis;calcium phosphate;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;career;Cell model;Cells;Cessation of life;ChIP-seq;Chromatin;Chromatin Structure;Chronic Kidney Failure;Clinical;Collaborations;Complex;Core Facility;Dangerousness;Data;Defect;Deposition;Dermal;Development;Diabetes Mellitus;Disease;disease model;Disease Progression;Dose;effective therapy;Environment;Epigenetic Process;Event;experimental study;extracellular;Faculty;Fostering;Funding;Gene Deletion;Genes;Genetic;Genetic Databases;Genetic Polymorphism;Goals;Grant;Homeostasis;Human;Human Genetics;improved;In Vitro;in vivo;inhibition of autophagy;inhibitor;insight;Investigation;Knowledge;Laboratories;Learning;matrix Gla protein;Medial;Mediating;member;Membrane;Mentors;Messenger RNA;Modeling;Molecular;Molecular Biology;Morbidity - disease rate;mortality;mouse model;Mus;novel;osteogenic;Pathogenesis;Pathway interactions;Patients;Peripheral arterial disease;pharmacologic;Phenotype;Predictive Factor;prevent;Process;Productivity;Program Development;programs;promoter;Protein Deficiency;Relaxation;Reporting;Research;Research Personnel;Role;Sirolimus;skills;small molecule inhibitor;Smooth Muscle Myocytes;Specimen;success;Techniques;Technology;Testing;Therapeutic;Therapeutic Effect;Therapeutic Studies;Training Programs;transcriptome sequencing;Transmission Electron Microscopy;treatment strategy;United States;Vacuole;Vascular calcification;Vascular Smooth Muscle;Vesicle;Writing

PROJECT_TITLE: Novel molecular mechanisms of vascular smooth muscle cell-mediated large and small artery calcification


NIH_SPENDING_CATS: Aging;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: GENNINGS, CHRIS  (contact)

PROJECT_TERMS: Acceleration;Address;Adult;advanced analytics;Air;analytical method;Bayesian Modeling;Big Data;Bioinformatics;Biological;Biometry;Clinical;Collaborations;Complex;complex data;Core Facility;Data;Data Analyses;Data Analytics;Data Science;data standards;design;Development;Diagnosis;Dimensions;Disease;disorder prevention;early life exposure;Educational workshop;Ensure;Environment;Environmental Exposure;Environmental Health;environmental justice;Epidemiologic Methods;Epidemiology;epigenomics;Evaluation;Exposure to;Faculty;Funding;Goals;Grant;Health;high dimensionality;high risk;Human;improved;Inequity;innovation;investigator training;K-Series Research Career Programs;Knowledge;late life;learning strategy;Life;Life Cycle Stages;life span;Linear Models;Machine Learning;Measures;Medicine;member;metabolomics;method development;Methodology;Methods;Mission;Modeling;multidimensional data;multiple omics;Names;National Institute of Environmental Health Sciences;novel;nutrition;Outcome;Paper;phenotypic data;Pilot Projects;Play;Poison;post-doctoral training;Postdoctoral Fellow;Probability;Process;Public Health;quality assurance;Race;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;Science;Scientist;Services;socioeconomics;sound;Statistical Methods;Statistical Study;Structure;success;Sum;symposium;Techniques;Time;tool;Toxicant exposure;Training;United States National Institutes of Health;water quality;Work

PROJECT_TITLE: Biostatistics and Data Science Facility Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Social Determinants of Health

ORG_CITY: GREENVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: EAST CAROLINA UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative We seek to establish a new MARC Program at East Carolina University (ECU) to provide an innovative and collaborative training environment that fosters professional development for underrepresented and disadvantaged undergraduates towards biomedical careers that require PhD and MD/PhD degrees. The program combines high-impact educational experiences for undergraduates with a strong interdisciplinary biomedical research program spanning nine departments in the College of Arts and Sciences and the Schools of Medicine and Dental Medicine. The program will broaden career options in biomedical sciences for undergraduates particularly from first-generation and ethnic minority backgrounds, which will increase social mobility and support the rapidly expanding regional biomedical and biopharmaceutical industry in the region.

PI_NAMEs: ABLES, ELIZABETH TWEEDIE (contact);AILERU, AZEEZ A;TRAN, TUAN DUNG

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;Award;Biomedical Research;career;Career Exploration;CCL7 gene;cohort;college;Communication;Communities;cost effective;design;Development;disadvantaged student;Discipline;Disparity;Doctor of Philosophy;doctoral student;Education;Environment;ethnic diversity;experience;faculty mentor;falls;Fostering;Funding;Goals;higher education;indexing;innovation;Institution;interdisciplinary curriculum;interest;matriculation;Mentors;Methods;peer coaching;Phase;Preparation;Process;programs;prospective;Publications;Qualifying;recruit;Research;Research Personnel;Resources;rural area;Science;Science, Technology, Engineering and Mathematics Education;skills;social;Social Mobility;STEM field;Structure;Students;Time;Training;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Students;Universities;Work

PROJECT_TITLE: MARC at East Carolina University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: AG

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative  Understanding how complex regulatory processes function in young cells and during aging will ultimately help delay many age-related diseases. Specifically, accumulating evidence suggests that immune cells, such as neutrophils, can be directly regulated by sex-steroid hormones, thus influencing immune responses – yet their impact remains dramatically understudied. This project aims at understanding how sex-hormones modulate neutrophil function throughout life, with the goal to, in turn, take advantage of this knowledge to reverse key aspects of immune dysfunction across biological sex.

PI_NAMEs: BENAYOUN, BERENICE ANATH (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Address;Adult;age related;age-related disease;Aging;Androgens;Animals;antimicrobial;base;Biological;Biological Process;biological sex;Biology;Biomedical Research;cell type;Cells;Chromatin;Chromosomes;Complex;Data;Development;Distant;Estrogens;Estrus;experimental study;Exposure to;Female;FOXL2 gene;functional decline;Gene Expression;Genetic;Genomics;genotypic sex;Goals;gonad development;Gonadal Hormones;Gonadal Steroid Hormones;Health;health disparity;Hormonal;hormone regulation;Human;Immune;Immune response;Immune System Diseases;Immunity;immunoregulation;Individual;individualized medicine;Infection;innovation;insight;Knowledge;Leukocytes;Life;Light;Link;lipidome;Lipids;machine learning model;male;Mediating;Mediator;metabolome;Microfluidics;Modeling;Molecular;Mus;neutrophil;Ovary;personalized medicine;Phenotype;Ploidies;Population;Predisposition;Process;Reproduction;Research;Resolution;Role;segregation;sex;Sex Bias;Sex Chromosomes;Sex Differences;sexual dimorphism;Shapes;single-cell RNA sequencing;System;targeted treatment;Testing;Testis;Testosterone;Time;transcriptome;transdifferentiation

PROJECT_TITLE: Deciphering hormonal regulation of neutrophil biology

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Social Determinants of Health

PI_NAMEs: WRIGHT, ROSALIND J (contact)

PROJECT_TERMS: Acceleration;Address;administrative database;Adolescence;Adult;Age;Area;biobank;Biological Markers;Biometry;built environment;Cardiometabolic Disease;Cardiovascular system;Chemicals;Child;Childhood;Clinical;Clinical and Translational Science Awards;clinical data warehouse;clinical phenotype;clinical translation;Collaborations;Communities;community engagement;Consultations;Core Facility;cost effective;Coupling;Crime;critical period;Data;Data Analyses;Data Collection;data reduction;Data Science;Data Set;data sharing;Decentralization;digital health;Disease;early childhood;Education;Educational workshop;Electronic Health Record;Endocrine;Endocrine System Diseases;Ensure;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Health;environmental justice;Environmental Risk Factor;Equipment;Faculty;Foundations;Funding;Gender;Grant;Growth;Health;health assessment;health care delivery;Health Food;health inequalities;Health Sciences;Health Status;Health system;Hospitals;Housing;Hydrocortisone;Hypersensitivity;hypothalamic-pituitary-adrenal axis;Immunophenotyping;Individual;infancy;Infrastructure;Institution;interoperability;K-Series Research Career Programs;Laboratories;Libraries;Life;Life Cycle Stages;life span;Link;Machine Learning;Measurement;Measures;Mediating;Mediation;meetings;member;Methodology;middle age;Mission;Modeling;Multivariate Analysis;National Institute of Environmental Health Sciences;Neighborhoods;neurodevelopment;novel;nutrition;Nutrition Assessment;Nutritional;Nutritional status;Obesity;older adult;Outcome;Pathway interactions;Patient Self-Report;performance based measurement;Phase;phenomics;Phenotype;Physiological;Pollution;Population;population based;Population Study;Positioning Attribute;pre-clinical;Pregnancy;Procedures;Protocols documentation;psychologic;Psychological Stress;Psychometrics;Psychosocial Stress;public health intervention;Publications;Research;Resolution;Resources;respiratory;Risk;Salivary;sample collection;Science;Services;Site;Sleep;social determinants;social health determinants;Social Network;spatiotemporal;Standardization;Stress;success;Surveys;Technical Expertise;Temperature;Time;tool;toxicant;Toxicant exposure;Training;Translating;Translational Research;wearable device;Work

PROJECT_TITLE: Phenotyping and Environmental Modifiers Facility Core


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: Research Triangle Park

ORG_NAME: EPICYPHER, INC.

PHR: PROJECT NARRATIVE  Monoubiquitination (Ub) of histones is an important post-translational modification (PTM) that regulates multiple DNA-related processes including DNA replication, transcription, and repair, and aberrant regulation of histone Ub is strongly linked to the pathogenesis of diverse diseases. However, the ability to map the distribution and dynamics of histone Ub signals has been challenged by a lack of high-quality detection reagents. Here, EpiCypher is developing UbSensors as next-generation affinity reagents to enable genomic mapping of monoubiquitinated nucleosomes and advance our understanding of histone Ub signaling.

PI_NAMEs: SUN, ZU-WEN  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Affinity;Aging;Antibodies;Bar Codes;Binding;Biochemical;Biological Assay;biomarker discovery;Cell Count;cell type;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Collaborations;Colorado;commercial launch;Data;design;Detection;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;Double Strand Break Repair;drug discovery;Epitopes;Exhibits;Gene Activation;gene repression;Genetic Transcription;genome-wide;Genomics;High Pressure Liquid Chromatography;Histones;improved;in vivo;in vivo imaging;Inflammation;innovation;Link;Malignant Neoplasms;manufacture;Maps;Methods;Modification;Monoubiquitination;nanomolar;next generation;Noise;novel;nuclease;Nucleosomes;Pathogenesis;Performance;Phase;Play;Post-Translational Protein Processing;Process;rational design;Reaction;Reader;Reagent;Recombinants;Regulation;repaired;Research;response;Role;Sampling;sensor;Signal Transduction;Site;Specificity;stability testing;Structure;Surface;synergism;Technology;Testing;tool;Ubiquitin;Universities;Validation

PROJECT_TITLE: Novel recombinant sensors to study histone ubiquitin signaling


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Breastfeeding, Lactation and Breast Milk;Clinical Research;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: Tyngsboro

ORG_NAME: MOTHER'S MILK IS BEST, INC.

PHR: The Human Milk Concentration (HMC) device will allow for the exclusive use of mother’s own milk when nourishing vulnerable preterm infants in need of high nutrient intake. The ability to fortify feedings with mother’s own milk, allowing the transfer of vital nutrients found only in mother’s milk to the child, can reduce illness and improve overall long-term health benefits for preterm infants.

PI_NAMEs: NELSON, ELIZABETH RANDALL (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Breast Feeding;care outcomes;Cattle;Cells;Child;Clinical Trials;commercialization;Dangerousness;design;Development;Devices;Duodenum;efficacy validation;Experimental Models;experimental study;Eye diseases;fabrication;feeding;Filler;Formulation;Fortification;Funding;Goals;Growth;gut health;Health;Health Benefit;Human Milk;Immune system;improved;Infant formula;innovation;Intake;Intestines;Lung Diseases;manufacture;mechanical properties;Medical;Medical Device;Membrane;Methods;microbiome;Milk;Milk Banks;Mission;Modeling;Mothers;mouse model;Mus;Neonatal;neonatal human;Neonatal Intensive Care Units;neonatal mice;Nutrient;nutrition;Osmosis;Output;Performance;Phase;point of care;Polymers;preclinical evaluation;Preclinical Testing;pregnant;Premature Infant;Process;prototype;Regulation;Reporting;Research;research clinical testing;Risk;Safety;Source;success;supply chain;System;Techniques;Technology;Temperature;Testing;Time;United States National Institutes of Health;Water;Work

PROJECT_TITLE: Point of Care maternal milk concentration device to optimize neonatal growth with targeted nutrition support

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(10)B]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: GALVEZ, MAIDA  (contact)

PROJECT_TERMS: Academy;Acceleration;Address;Adult;Advocacy;Air Pollution;American;Architecture;Awareness;Black race;Center for Translational Science Activities;Childhood;Clinic;Clinical;Clinical and Translational Science Awards;clinical practice;Clinical Treatment;Collaborations;Communication;Communities;community building;community engaged approach;community engagement;Community Health;community partners;community partnership;community planning;community violence;Consultations;data visualization;design;Development;Discipline;Education;Educational Curriculum;Educational Models;Environment;Environmental Exposure;Environmental Health;environmental justice;Equity;Evaluation;evidence base;Evidence based intervention;Family;Fostering;Geographic Locations;Geography;Goals;Health;health communication;health disparity;health equity;health inequalities;health knowledge;health literacy;Health Professional;Health Promotion;health science research;Housing;innovation;Institutional Racism;Knowledge;Latinx;Life;Life Cycle Stages;life span;Low income;Measurable;Medical Education;member;Methods;Mission;Modeling;National Institute of Environmental Health Sciences;Neighborhoods;New York City;novel strategies;Outcome;outcome disparities;Outcome Measure;Patients;Pediatrics;Personal Satisfaction;Policies;Policy Maker;Pollution;Prevention;programs;Public Health;Public Health Practice;Recording of previous events;Research;Research Activity;Research Personnel;Resolution;Resources;Role;Shapes;Side;social;Source;Stress;Students;success;tool;Training;training opportunity;Translating;Translational Research;Translations;Voice;Work

PROJECT_TITLE: Community Engagement Core


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Women's Health Research

ORG_CITY: Nashville

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Depression is prevalent, debilitating, and costly, and maternal depression is one of the most established risk factors of depression in offspring; however, the genetic and environmental risk factors tied to intergenerational risk are complex and largely unspecified. I will conduct a multimodal, dyadic research design to examine a potential neurobehavioral pathway from depression in mothers to the development of increased depression risk in young children. This study has relevance for identifying children at greatest risk for depression development according to neural indicators and proposing a behavioral target for intervention in mother−child processes in order to mitigate risk.

PI_NAMEs: HILL, KAYLIN ESTELL (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adult;Affect;Age;antepartum depression;Attention;Behavior;Behavior assessment;Behavioral;Behavioral Paradigm;Caregivers;caregiving;Child;Code;Complex;cost;depressive symptoms;Development;Diagnostic;Disparate;dyadic interaction;early childhood;Early identification;Electroencephalography;Emotional;Environmental Risk Factor;Event-Related Potentials;experience;Frequencies;Funding;Future;Genetic;genetic risk factor;Goals;high risk;Human;Individual Differences;Infant;innovation;insight;intergenerational;Intervention;Interview;Investigation;Laboratories;Life Experience;Literature;maternal depression;Maternal Deprivation;Measures;Mental Depression;Mental disorders;Mental Health;Mentors;Methods;Mother-Child Relations;Mothers;Motivation;multimodality;National Institute of Mental Health;neural;neurobehavioral;Neurobiology;neurophysiology;nonhuman primate;offspring;Pathway interactions;Pattern;Play;pleasure;Positive Valence;Postpartum Period;Pregnancy;Prevention;Process;Psychopathology;Recording of previous events;Research;research and development;Research Design;Research Domain Criteria;Research Methodology;Research Project Grants;Research Proposals;response;Rewards;Risk;Risk Factors;risk mitigation;Rodent;Role;Sampling;School-Age Population;Series;Shapes;skills;social attachment;Social Processes;Stimulus;System;Systems Development;Testing;Training;transmission process;Visit;Woman

PROJECT_TITLE: Neurobehavioral markers of positive valence systems in mothers with depression and young offspring

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will uncover mechanisms of epilepsy – a disease that directly affects roughly 1.2 % of the US population. We will gain insight to neural mechanisms of epileptic activity and how such activity impacts impaired memory processing. This work speaks directly to the 2020 NINDS epilepsy benchmark area 1: to understand the cause of epilepsies and related neurological conditions – in this case, impaired memory.

PI_NAMEs: EWELL, LAURA  (contact)

PROJECT_TERMS: Acute;Affect;Animals;Area;Behavioral;Benchmarking;Cells;Chronic;comorbidity;Coupled;Data;density;Disease;Electrophysiology (science);Epilepsy;experience;Genetic;Genetic Techniques;Hippocampus;Hour;improved;in vivo;insight;Intervention;kainate;Knowledge;Laboratories;Location;long term memory;Memory;Memory impairment;memory process;Microelectrodes;Monitor;mouse model;Mus;National Institute of Neurological Disorders and Stroke;Nature;Neurologic;neuromechanism;Neurons;Patients;Pattern;Performance;Phase;Physiological;place fields;Population;Public Health;recruit;Research;Seizures;shared memory;Short-Term Memory;Sleep;Source;Synapses;Temporal Lobe Epilepsy;Testing;Work

PROJECT_TITLE: Determining the shared neuronal network mechanisms of focal epileptic discharges and impaired memory processing in temporal lobe epilepsy


NIH_SPENDING_CATS: Aging;Clinical Research;Social Determinants of Health

PROJECT_TERMS: Acceleration;Aging;Applications Grants;Attention;Award;Awareness;Biology;career;career development;Cities;Clinical;Clinical and Translational Science Awards;clinical translation;Collaborations;Communities;community based participatory research;community engagement;community partners;Core Facility;Data;Data Science;Dermatology;design;Direct Costs;Ensure;Environment;Environmental Health;environmental justice;experience;Extramural Activities;Faculty;Faith;Feedback;Funding;Future;Genetic;global health;Goals;Grant;Growth;Health;health science research;Incentives;Individual;innovation;Institution;Investments;Joints;K-Series Research Career Programs;Legal patent;Life Cycle Stages;life span;Malignant Neoplasms;member;Mission;Modeling;National Human Genome Research Institute;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Environmental Health Sciences;National Institute of General Medical Sciences;National Institute on Minority Health and Health Disparities;Nephrology;Neurosciences;New York;Oncology;Otolaryngology;Pediatrics;Peer Review;Phenotype;Pilot Projects;Postdoctoral Fellow;Procedures;Process;professor;Program Development;Program Reviews;programs;public health emergency;Publications;Research;Research Personnel;Research Project Grants;Research Proposals;Science;Skin;Source;Study Section;success;symposium;Translational Research;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Pilot Project Program


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Narrative Statement This project is designed to evaluate the capacity of senolytic agents to eliminate breast tumor cells induced into senescence by chemotherapy and radiation, with studies in both cell culture and tumor bearing animals, and to identify the contribution(s) of the immune system to the effectiveness of this therapeutic strategy.

PI_NAMEs: GEWIRTZ, DAVID A. (contact);HARADA, HISASHI ;LANDRY, JOSEPH WILLIAM

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Aftercare;Animals;anti-tumor immune response;Antigens;Antitumor Response;Apoptotic;assault;BCL1 Oncogene;BCL2L1 gene;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;cancer recurrence;Cell Culture Techniques;Cell Death;cell growth;Cell Survival;Cells;Characteristics;chemotherapy;Chemotherapy and/or radiation;Clinic;Clinical Trials;Cross Presentation;Cytolysis;Data;defined contribution;design;Disease;Dose;drug sensitivity;Effectiveness;Experimental Designs;experimental study;Exposure to;Goals;Growth;Human;Immune;Immune response;Immune system;immunogenic;immunogenic cell death;Immunologic Stimulation;In Vitro;in vitro Model;in vivo;Induction of Apoptosis;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Modeling;Monitor;mortality;mouse model;Mus;Natural Killer Cells;Nature;neoplastic cell;novel;Outcome Study;Patients;Phenotype;Population;pre-clinical;preclinical study;prevent;Property;Protein Family;Protocols documentation;Radiation;Radiation Tolerance;Recovery;Recurrent disease;Residual Neoplasm;Residual state;response;Role;Sampling;self-renewal;senescence;senescent cell;senolytics;Sequential Treatment;Series;Site;Sorting;Stable Disease;Stains;T-Lymphocyte;Testing;Therapeutic;Therapeutic Agents;therapeutic effectiveness;Time;Toxic effect;translational goal;Treatment Protocols;treatment response;tumor;Tumor Immunity;Tumor-infiltrating immune cells;Work;Xenograft procedure

PROJECT_TITLE: A sequential therapeutic strategy of senescence induction and senolytics for elimination of surviving residual breast tumor cells

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Aging;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Mental Illness;Patient Safety;Post-Traumatic Stress Disorder (PTSD);Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: This study will determine if specific PTSD symptoms have varying associations with adverse T2D and CVD outcomes, including mortality, in patients with comorbid PTSD and T2D/CVD . We will determine if large, clinically meaningful PTSD improvement is associated with a lower risk for adverse T2D and CVD outcomes and test whether measures of T2D/CVD disease management mediate the association between PTSD improvement and adverse outcomes . We expect our results will eventually lead to T2D and CVD treatment guidelines that incorporate treatment of PTSD as a component of T2D/CVD disease management.

PI_NAMEs: SCHERRER, JEFFREY F. (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Accounting;Address;Adverse event;adverse outcome;African American;Age;age difference;age group;Arousal;associated symptom;blood pressure control;burden of chronic illness;Cardiac rehabilitation;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cessation of life;Characteristics;Clinical;Clinical Trials;Cognition;comorbidity;Complications of Diabetes Mellitus;Confounding Factors (Epidemiology);Data;Data Collection;Data Sources;design;Diabetes Mellitus;Diagnosis;Disease;Disease Management;Disease Outcome;disparities in morbidity;Disparity;disparity reduction;DSM-V;experience;Funding;Future;Gender;glycemic control;Goals;Grant;Guidelines;Health behavior;health disparity;High Prevalence;Hospitalization;Hypertension;improved;improved outcome;indexing;Individual;Knowledge;Laboratories;Link;Literature;Measures;Mediating;Mediator;Medical Records;medication compliance;Mental Depression;Mental disorders;Minority;modifiable risk;Moods;mortality;Myocardial Infarction;National Heart, Lung, and Blood Institute;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Patients;Persons;Pharmaceutical Preparations;Phenotype;Post-Traumatic Stress Disorders;Premature Mortality;Provider;Psychotherapy;public health priorities;Race;racial population;Recurrence;Reduce health disparities;reduce symptoms;Research;Residual state;Risk;Risk Factors;Risk Reduction;Sampling;Self Care;Severities;Stroke;Symptoms;Testing;Time;treatment guidelines;Treatment outcome;Underrepresented Populations;United States;United States Department of Veterans Affairs;Veterans Health Administration;Work

PROJECT_TITLE: Clinically Meaningful PTSD Improvement: Reducing Risk for Adverse Outcomes in Comorbid Cardiometabolic Disease

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Aging;Clinical Research;Digestive Diseases;Lung;Microbiome;Orphan Drug;Physical Injury - Accidents and Adverse Effects;Rare Diseases;Wound Healing and Care

ORG_CITY: Aurora

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Damaging more than just the skin, burn injuries can lead to sepsis and multi-organ failure, often stemming from a breach in the intestinal epithelial barrier allowing translocation of bacteria and bacterial products into systemic circulation, triggering excessive inflammation in critical organs like the lung. Advanced age is an independent risk factor for mortality after burn injury, even in patients with relatively small burns, in part, because elderly burn patients are unable to combat infectious challenges, like pneumonia, a common complication seen after traumatic injury. By identifying mechanisms responsible for early damage to the gut barrier after injury and tracking dysbiosis and eventual restoration of the fecal microbiome in both our murine model of burn injury and in older burn patients, we hope to reduce the impact of this post-burn pathophysiology in patients who are at risk of developing lung infections and respiratory failure

PI_NAMEs: KOVACS, ELIZABETH J. (contact)

PROJECT_TERMS: Abbreviations;Acute;acute hypoxemic respiratory failure;Acute Respiratory Distress Syndrome;Adult;Adverse effects;Age;age effect;aged;Aging;Analysis of Variance;anti-microbial peptide;Architecture;Attenuated;Bacteria;Bacterial Translocation;Biological Markers;Blood;Body Surface Area;Bronchoalveolar Lavage;Burn injury;Burn Trauma;burn wound;CCL2 gene;Cell Death;Circulation;Clinical;Clinical Research;clinically relevant;Colony-forming units;combat;commensal bacteria;Complication;Cutaneous;CXCL2 gene;cytokine;cytokine release syndrome;Data;Development;Distal;Distant;dysbiosis;Elderly;Endothelial Cells;Epithelial Cell Proliferation;Epithelial Cells;experimental study;Exposure to;Extravasation;fecal microbiome;fecal microbiota;Functional disorder;functional improvement;Goals;gut microbiome;gut microbiota;gut-lung axis;HDAC1 gene;Health protection;Hematoxylin and Eosin Staining Method;Histone Deacetylase;IL8 gene;Immune response;Immunosuppression;Impairment;improved;indexing;Infection;Inflammaging;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;injured;Injury;Institutional Review Boards;Interleukin-1 beta;Interleukin-6;Interleukin-8;Interleukins;intestinal barrier;intestinal epithelium;intestinal fatty acid binding protein;Intestines;Invaded;Ischemic Bowel Disease;islet;kinase inhibitor;Knock-out;Knowledge;Lead;leukocyte activation;Leukocytes;Lipopolysaccharides;Lung;Lung infections;Macrophage;MAP Kinase Gene;Mechanical ventilation;Mediating;Mediator;mesenteric lymph node;microbial;microbiome;microbiome composition;Minor;Mitogen-Activated Protein Kinases;Molecular;Monitor;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Multiple Organ Failure;Mus;MYLK gene;Myosin Light Chain Kinase;Myosin Light Chains;Natural regeneration;novel;novel therapeutics;occludin;old mice;operational taxonomic units;Organ;Organ failure;Outcome;overexpression;pathogen;Patients;Pattern;Permeability;Phosphotransferases;Physiology;Play;Pneumonia;Production;Proteins;Pulmonary Edema;Pulmonary Inflammation;Respiratory Failure;response;restoration;RIPK3 gene;Risk;Risk Factors;Role;Sepsis;Septic Shock;Severities;Skin;Skin injury;STAT protein;stem;systemic inflammatory response;Testing;Therapeutic Intervention;Tight Junctions;time use;tissue injury;Tissues;TNF gene;Toll-like receptors;Trauma;Traumatic injury;Travel;Volatile Fatty Acids;Wild Type Mouse;Work;wound care

PROJECT_TITLE: Aging, Macrophage Mediators, and Burn Trauma

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Orphan Drug;Rare Diseases

PHR: NARRATIVE The goal of this project is to i) test novel myeloid activating therapies (CANDI) which have shown remarkable efficacy in proof-of-principle in glioblastoma studies and ii) improve our understanding of the immune environment by repeat sampling and analysis using recently developed highly multiplexed novel imaging methods. The new methods will allow us to perform in depth studies and will likely lead to new insight and experimental therapies in this devastating disease. Ultimately, we hope to improve our temporal understanding of the glioblastoma microenvironment and apply the gained knowledge to the design of future trials.

PI_NAMEs: WEISSLEDER, MD, PHD, RALPH  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Adjuvant;Biological Markers;Cancer Model;Cells;Clinical;Clinical Trials;Complex;Cyclodextrins;cytokine;Data;design;Disease;Dose;drug distribution;efficacy evaluation;Environment;Excision;experimental study;Female;Fine needle aspiration biopsy;Future;Genomics;Glioblastoma;Glioma;Goals;Hand;imaging modality;Immune;Immune response;Immunohistochemistry;Immunologic Stimulation;Immunophenotyping;Immunosuppression;Immunotherapy;improved;In Situ;in vivo;innovation;insight;interest;Interferon Type II;Interleukin-12;intravital microscopy;Investigational Therapies;Knowledge;male;Malignant Neoplasms;Maps;Measurement;Methods;Modeling;mouse model;Mus;Myelogenous;Myeloid Cells;nano;nanoparticle;new technology;NF-kappa B;novel;novel therapeutic intervention;Operative Surgical Procedures;Pathway interactions;Peripheral;Pharmaceutical Preparations;pre-clinical;Production;resistance mechanism;Resolution;response;Sampling;Shapes;Signal Transduction;small molecule;Specimen;Stat3 protein;systemic toxicity;T-Lymphocyte;Technology;Testing;Therapeutic Intervention;therapeutic target;Time;TLR7 gene;tool;transcriptomics;Treatment Efficacy;treatment response;tumor;tumor microenvironment;tumor-immune system interactions;Work

PROJECT_TITLE: Temporal analysis of the GBM tumor microenvironment during myeloid cell activating therapy

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ORG_CITY: PITTSBURGH

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Title: Targeting androgen receptor nuclear localization in prostate cancer Castration-resistant prostate cancer (CRPC) is currently incurable and is the second leading cause of cancer death in American men. Androgen-independent activation of the androgen receptor (AR) remains the major driving force leading to CRPC. Characterization and development of a novel nuclear AR degrader (NARD) may lead to new approaches to prevent and/or treat CRPC.

PI_NAMEs: WANG, ZHOU  (contact);WIPF, PETER

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: American;analog;Androgen Antagonists;androgen independent prostate cancer;Androgen Receptor;Androgens;Binding;Binding Proteins;Biological Assay;cancer diagnosis;Cancer Etiology;Castrate sensitive prostate cancer;Castration;Cell Nucleus;Cessation of life;Co-Immunoprecipitations;Coupled;Data;Development;driving force;Drug Kinetics;effective therapy;efficacy evaluation;enzalutamide;Fractionation;Generations;Goals;high throughput screening;Importins;improved;in vivo;knock-down;Lead;Malignant neoplasm of prostate;Mediating;men;Microsomes;Modeling;novel;novel strategies;Nuclear;Nuclear Import;Nuclear Receptors;overexpression;patient population;Patients;Pharmaceutical Chemistry;Plasma Proteins;prevent;prostate cancer cell;prostate cancer prevention;prostate cancer progression;Prostate Cancer therapy;receptor expression;Resistance;screening;Small Interfering RNA;small molecule;Specificity;success;synergism;targeted agent;Testing;Therapeutic;Therapeutic Agents;therapeutic target;tool;transcription factor;tumor;tumor growth;tumor xenograft;ubiquitin-protein ligase;Ubiquitination;Work;Xenograft procedure


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: We propose to study how adhesion receptor integrins, particularly platelet integrin aIIbb3 (also called GPIIb- IIIa) and leukocyte b2 integrins, transmits signals into cells to induce cellular responses, which cause thrombosis and inflammation leading to diseases such as heart attack and sepsis. By exploring integrin signaling mechanisms, we will also investigate the new approaches to develop dual anti-platelet and anti- clotting drugs that do not cause bleeding, and to develop dual anti-thrombotic and anti-inflammatory drugs that do not cause bleeding for treatment of heart attack, stroke as well as sepsis.

PI_NAMEs: DU, XIAOPING  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Acute;adhesion receptor;Adhesions;Adverse effects;Agonist;Amphotericin B;Anti-Inflammatory Agents;Anticoagulants;Antiplatelet Drugs;Aspirin;Atherosclerosis;Binding;Blood Platelets;Cardiovascular Diseases;Cause of Death;cell motility;Cells;Chronic;Clinical;Coagulation Process;cytokine;Cytoplasmic Tail;Disease;Family;Fibrin;GTP-Binding Proteins;Hemorrhage;Hemostatic function;Inflammation;Inflammatory;Integrins;Leukocytes;Life;Mediating;Morbidity - disease rate;mortality;Myocardial Infarction;novel strategies;Phagocytosis;Pharmaceutical Preparations;Play;prevent;Protein Subunits;response;Risk;Role;Sepsis;Signal Transduction;Site;Stroke;thromboinflammation;Thrombosis;thrombotic;Thrombus;transmission process;vascular injury

PROJECT_TITLE: Mechanisms of integrin signaling and a new anti-platelet/anti-inflammatory approach


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Alzheimer’s disease and related dementias continue to be a critical public health issue because they are prevalent and have significant emotional, relational, and financial costs. Purpose in life is a psychological resource that buffers against ADRD at every stage of the disease and may be a powerful target of intervention because it is malleable and its positive correlates wide-reaching. It is now necessary to identify the putative mechanisms of action that explain how purpose leads too healthier cognitive outcomes to develop effective interventions for healthier cognitive outcomes.

PI_NAMEs: SUTIN, ANGELINA R (contact)

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: Address;Adult;Affect;Affective;Alzheimer's disease related dementia;Alzheimer's disease risk;Attention;Basic Science;Behavior;Behavioral;Behavioral Symptoms;Belief;Buffers;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Chronic Disease;Clinical;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive performance;cognitive task;critical period;Dementia;dementia care;dementia risk;Development;Diabetes Mellitus;Diagnosis;Disease;Ecological momentary assessment;Education;effective intervention;Emotional;Ethnic Origin;evidence base;Family;Feeling;Financial cost;Goals;Health Promotion;Healthcare Systems;Impaired cognition;improved;improved outcome;Income;Individual;Intervention;Life;Literature;Longevity;Mediating;Meta-Analysis;middle age;mild cognitive impairment;Modeling;neuropathology;older adult;Outcome;Patients;Performance;Physical activity;Population Heterogeneity;Population Intervention;premature;prevent;Prevention;promote resilience;protective effect;protective factors;psychologic;psychological symptom;Public Health;Race;Randomized, Controlled Trials;reduce symptoms;Research;Resources;response;Risk;Risk Reduction;Smoking;Syndrome;Testing;therapy development;Time;Variant

PROJECT_TITLE: Purpose in life: Mechanisms to support healthier cognitive aging and reduce risk of Alzheimer's disease


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Cooley's Anemia;Digestive Diseases;Gene Therapy;Genetics;Hematology;Liver Disease;Orphan Drug;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE There are many patients of a-thalassemia, current therapies are insufficient for many of them and there are very few studies on a-thalassemia; in addition, no severe mouse models are available to study this disease and to test new therapies. Our goals are to generate new mouse models to investigate this understudied disease and to test if a newly generated lentiviral vector that expresses the human a-globin gene can correct mice affected by severe forms of a-thalassemia. Our proposed work will address these knowledge gaps by developing, characterizing, and validating mouse models and gene therapy vectors for treating severe a-thalassemia.

PI_NAMEs: RIVELLA, STEFANO  (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Adult;Adverse effects;Affect;Allogeneic Bone Marrow Transplantation;Allogenic;alpha Globin;alpha-Thalassemia;Anemia;Animals;Area;beta Globin;beta Thalassemia;Blood Transfusion;Cell Line;Cells;Cessation of life;Clinical;Clinical assessments;Coagulation Process;curative treatments;Deposition;design;Development;Disease;disease phenotype;Emigrations;Erythrocytes;Erythroid;Erythroid Cells;Erythropoiesis;Erythropoietin;ethnic minority;Event;experience;expression vector;Failure to Thrive;Fetal Liver;Functional disorder;Gene Deletion;gene therapy;Gene Transduction Agent;Genes;Genetic;Genetic Diseases;genome editing;Geographic Locations;Goals;Graft Rejection;graft vs host disease;Hematocrit procedure;Hematology;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobin concentration result;Hemoglobinopathies;Hepatosplenomegaly;hepcidin;Human;Hypoxemia;improved;Individual;Inherited;insight;interest;Iron;iron metabolism;Iron Overload;Kidney;Knock-out;Knowledge;Lentivirus Vector;Life;life span;Liver;Locus Control Region;mature animal;Modeling;Modification;mouse model;Multiple Organ Failure;Mus;Mutation;novel;novel strategies;novel therapeutics;Organ;Oxygen;Pathology;Patients;Periodicals;Phenotype;prevent;Production;promoter;Proteins;Publishing;racial minority;Safety;Sickle Cell Anemia;socioeconomics;Splenomegaly;Techniques;Testing;Therapeutic;therapeutic gene;tool;Transplantation;Validation;vector;Work

PROJECT_TITLE: Development and validation of novel mouse models and expression vectors for characterizing severe alpha-thalassemia pathophysiology and evaluating gene therapy approaches.

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Digestive Diseases;Pediatric

ORG_CITY: NEW YORK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE The emergence of precise physical patterns during embryonic development is critical for the birth of a healthy and fully functional organism. The present application addresses this inherently multidisciplinary problem in the context of looping of the small intestine, a process driven by mechanical buckling of the initially straight tube that allows the lengthy intestine to be packaged within the abdomen. Advancing our understanding of how molecular cues control forces to shape the embryo, and the potential biological importance of the forces themselves, may shed light on the underlying causes of congenital disorders such as midgut volvulus, and provide inroads to the manipulation of forces to engineer tissues and organs in the lab.

PI_NAMEs: NERURKAR, NANDAN L (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: 3-Dimensional;Abdomen;Actomyosin;Address;Adolescence;Area;Automobile Driving;Back;Behavior;Biological;Biology;Bioreactors;Birth;body cavity;cell behavior;Cell Count;Cell Proliferation;Cell Size;cell type;Cell Volumes;Cells;Cerebral cortex;Chick;Collecting Tube;Congenital Abnormality;Congenital Disorders;Cues;Dependence;design;Development;driving force;Elasticity;Embryo;Embryonic Development;Engineering;experimental study;Extracellular Matrix;Feedback;follow-up;FRAP1 gene;Genes;Geometry;Goals;Growth;Hand;insight;Intestinal Obstruction;Intestinal Volvulus;Intestines;Length;Link;mathematical model;Measurement;Measures;mechanical drive;mechanical force;Mechanics;Mediating;Mesentery;Microbial Biofilms;Midgut;Molecular;Morphogenesis;Morphology;mortality risk;multidisciplinary;Operative Surgical Procedures;Organ;Organism;Organogenesis;Pathway interactions;Pattern;Pharmacological Treatment;Phenotype;physical process;physical property;Physics;Play;Prevalence;Process;Proliferating;Regenerative Medicine;Regulation;repaired;Role;Shapes;Signal Pathway;Signal Transduction;Small Intestines;Specific qualifier value;Stereotyping;stereotypy;Stress;Stretching;Study models;Surface;Testing;Tissue Engineering;Tissues;Tube;Work

PROJECT_TITLE: Molecular control of mechanical forces driving buckling morphogenesis of the small intestine

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Racial and Ethnic Minority Health Research

ORG_DEPT: PEDIATRICS

PHR: NARRATIVE Asthma is an important public health problem among Dominican and Puerto Rican adults in the U.S. Altered gene expression in airway epithelium may lead to dysfunction of epithelial integrity and function, abnormal immune responses, and -ultimately- asthma and asthma morbidity. Identifying epigenetic and transcriptomic determinants and/or markers of asthma outcomes in nasal (airway) epithelium from Dominican and Puerto Rican adults should have major implications for disease prevention and management in these underserved ethnic groups. .

PI_NAMEs: CELEDON, JUAN CARLOS (contact);ISASI, CARMEN R.

PROGRAM_OFFICER_NAME: GAN, WEINIU

PROJECT_TERMS: Abbreviations;Adolescent;Adult;Affect;African American;airway epithelium;airway inflammation;Asthma;asthma exacerbation;asthma model;Biology;Bronchodilator Agents;Central American;Child;Childhood Asthma;Classification;Cross-Sectional Studies;Data;Development;disease heterogeneity;Disease Management;disorder prevention;disorder risk;DNA Methylation;Dominican;Environment;Epidemiology;Epigenetic Process;epigenetic regulation;epigenome-wide association studies;epigenomics;Epithelium;Ethnic Population;European;Extrinsic asthma;Functional disorder;Gene Expression;Gene Expression Regulation;Genes;Genetic;genome wide association study;genome-wide;genomic locus;Genotype;Goals;Heredity;high risk;Hispanic;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Human;Immune response;immunoregulation;Interdisciplinary Study;Knowledge;Mediating;Meta-Analysis;Methylation;methylation biomarker;Mexican Americans;Molecular Biology;Morbidity - disease rate;Nasal Epithelium;Nonpharmacologic Therapy;Nose;Not Hispanic or Latino;novel;Outcome;Pathogenesis;Pathway Analysis;pharmacologic;Play;prevent;Public Health;Puerto Rican;pulmonary function;pulmonary function decline;Quantitative Trait Loci;Regulatory Pathway;Research;response;Severities;Subgroup;Testing;trait;transcriptome;transcriptomics;Underserved Population;validation studies

PROJECT_TITLE: Nasal epithelial epigenomics and transcriptomics and asthma in Hispanic adults


NIH_SPENDING_CATS: Biotechnology;Kidney Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: SALSBURY COVE

ORG_NAME: MOUNT DESERT ISLAND BIOLOGICAL LAB

ORG_STATE: ME

PHR: Project Narrative The kidney filters and processes the blood to maintain the proper fluid environment for all body cells. For kidney filtering units, nephrons, to function and convey fluid, they must make new connections to existing tubules and generate functional kidney "plumbing". Making connections will be particularly important to make it possible to engraft new, stem cell derived nephrons to an existing kidney. We aim to show how interconnection happens and how this process can be stimulated to allow new, implanted kidney tissue to replace the function of damaged kidneys, preventing complete kidney loss and averting kidney failure.

PI_NAMEs: DRUMMOND, IAIN A. (contact);MARCIANO, DENISE K;OXBURGH, LEIF

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: 3-Dimensional;Adult;Basement membrane;Bioinformatics;Biological Assay;Blood;Cause of Death;Cell Aggregation;Cell Culture System;Cell Culture Techniques;Cell fusion;Cells;Coupled;Data;Development;Dialysis procedure;Distal;End stage renal failure;Engineering;Engraftment;Environment;Epithelial Cells;Epithelium;Event;Excision;experimental study;Extracellular Matrix;Fibroblast Growth Factor;Filtration;Fishes;Genetic;genetic analysis;glucose uptake;Goals;Human;Immune;Implant;In Situ Hybridization;In Vitro;in vivo;in vivo engraftment;in vivo evaluation;Injury;insight;Invaded;Investigation;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;Legal patent;Ligands;Liquid substance;Mammalian Cell;Matrix Metalloproteinases;Mediating;Methodology;Modeling;Molecular;Mus;mutant;Mutation;Natural regeneration;nephrogenesis;nephron progenitor;Nephrons;Organoids;Output;Pathway interactions;Patients;Pattern;Phenotype;Plumbing;Pluripotent Stem Cells;polarized cell;prevent;Process;programs;receptor;recruit;regenerative therapy;renal damage;Renal function;Renal tubule structure;repaired;Reporting;Role;scale up;Series;Signal Pathway;Signal Transduction;Site;specific biomarkers;stem cell organoids;stem cells;Structure;System;Technology;Testing;three dimensional cell culture;Tissue Inhibitor of Metalloproteinases;Tissues;tool;transcriptomics;urinary;Urine;WNT Signaling Pathway;WNT9A gene;Work;Zebrafish

PROJECT_TITLE: Identifying pathways required for integration of kidney organoid and host epithelia


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Caregiving Research;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative/Public Health Relevance Based on a longitudinal sample of 200 participants who have been followed for over 40 years beginning before birth, the proposed research will examine prospectively the impact of adversity and social support on adult indicators of aging. We will test the effects of timing and chronicity (i.e., onset and trajectories) of adversity on adult cognitive, neurobiological, and epigenetic markers of aging as well as the moderating influence of relationship support, especially positive early caregiving, on these associations. Understanding the mechanisms by which adverse experiences negatively impact adult functioning and accelerate aging and the role of social relationships in ameliorating these relations will inform policy and contribute to the development of targeted approaches to prevention and intervention.

PI_NAMEs: CARLSON, ELIZABETH A (contact);THOMAS, KATHLEEN M

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Address;Adult;Adverse event;Age;age acceleration;age related;age related changes;age related decline;Aging;aging biomarker;aging process;Animals;Behavioral;Behavioral Research;biobehavior;Biological;biological systems;Birth;Brain;brain health;Buffers;caregiving;Chronic;Cognition;Cognitive;Cognitive aging;cognitive function;Cohort Studies;connectome;cost;Data;Data Analytics;design;Development;DNA Methylation;early experience;early life adversity;Emotions;epigenetic aging;epigenetic marker;Epigenetic Process;epigenetic variation;Event;experience;Exposure to;Foundations;Genetic;Growth;Hippocampus;Human;Individual;Intercept;Intervention;Investigation;Length;Life;Life Cycle Stages;Link;longitudinal dataset;Longitudinal Studies;Measures;Methodology;Minnesota;Modeling;Neurobiology;Neurophysiology - biologic function;neurotoxicity;novel;Outcome;Participant;physical conditioning;Policies;Prefrontal Cortex;Prevention;Prevention approach;Prevention strategy;prospective;psychosocial;Public Health;public health relevance;Research;Retrospective Studies;Risk;Role;Sampling;Sensorimotor functions;social relationships;Social support;Structure;Techniques;telomere;Testing;Variant;Work

PROJECT_TITLE: Adult Cognitive and Neurobiological Indicators of Aging: Impact of Adversity and Social Support

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: LEXINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Our overarching scientific premise is that Alzheimer’s disease interventions and pre- symptomatic disease diagnostics remain elusive, in part, because we still do not understand exactly how top genes are driving disease. Our group seeks to help develop a pre-symptomatic disease diagnostic and a meaningful therapy by identifying specific molecular modifications, and therefore specific mechanisms, driving disease using long-range optical DNA mapping and sequencing technologies.

PI_NAMEs: EBBERT, MARK T W (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: advanced disease;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnostic;Alzheimer's disease risk;Automobile Driving;Biology;Brain;brain control;Brain Diseases;brain health;brain tissue;Clinic;cohort;Complement;Complex;Data;Data Set;design;Detection;Development;Diagnostic;differential expression;Disease;disease diagnosis;disease diagnostic;DNA;DNA mapping;DNA sequencing;frontal lobe;gain of function;Genes;genome-wide;genome-wide analysis;Goals;Grant;Individual;insight;Intervention;Maps;Methods;Modification;Molecular;multiple omics;Mutation;Neurodegenerative Disorders;Nucleotides;Optics;Phenotype;Play;Prognosis;programs;Protein Isoforms;Proteins;Research Personnel;risk variant;RNA;RNA Splicing;Role;Sampling;Symptoms;targeted treatment;Technology;Therapeutic;transcriptome sequencing;Validation;Variant;Work

PROJECT_TITLE: Using long-range technologies as a multi-omic approach to understand Alzheimer’s disease in brain tissue

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: The overall goal of this proposal is to advance our understanding of human neurogenesis by determining the identity and neurogenic potential of postnatal putative human neural stem cells. We will investigate equivalent cells in mice as an animal model to understand this novel population of postnatal neural stem cells.

PI_NAMEs: ALVAREZ-BUYLLA, ARTURO  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Adolescent;Adult;adult neurogenesis;Age Months;Animal Model;Anterior;Apical;Astrocytes;Birth;Brain;Brain Neoplasms;brain repair;Bromodeoxyuridine;Cell Physiology;cell type;Cells;Characteristics;Child;Childhood Neurological Disorder;Data;Derivation procedure;Development;Electron Microscopy;Embryo;Exhibits;frontal lobe;Gene Expression Profile;Generations;gliogenesis;Goals;Human;Immunodeficient Mouse;In Vitro;in vivo;Infant;Knowledge;Label;lateral ventricle;light microscopy;Link;mathematical model;Medial;Methods;Microdissection;migration;Morphology;Mus;Mutation;nerve stem cell;neurodevelopment;neurogenesis;Neuroglia;neuron regeneration;Neuronal Differentiation;neuronal replacement;Neurons;novel;novel strategies;olfactory bulb;Oligodendroglia;Perinatal;Population;postnatal;postnatal development;postnatal human;predictive modeling;Prefrontal Cortex;progenitor;Proliferating;Property;Prosencephalon;Quinones;Radial;recruit;Regenerative Medicine;Resolution;Rodent;single cell genomics;stem cell function;stem cells;Subependymal;subventricular zone;Techniques;Testing;Thymidine;transcriptomics;Transplantation;Ventricular;Work;Xenograft procedure

PROJECT_TITLE: Characterization of Neural Stem Cells in Adult Brain

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Cannabinoid Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Endocannabinoid System Research;Genetics;Human Genome;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Despite increasing prevalence and potency of marijuana use in pregnancy in the US, little is known regarding biological pathways underlying its impact on offspring neurodevelopment in humans. We propose to compre- hensively interrogate the genomic features of the placenta--a key organ which regulates the in utero environ- ment--to elucidate biological pathways underlying the impact of prenatal marijuana on newborn growth and neu- rodevelopment. Results from this study offer potential to (a) identify high-risk groups, (b) identify new biomarkers of exposure and fetal harm, and (c) identify novel molecular targets for intervention efforts to improve pregnancy and long-term offspring health outcomes.

PI_NAMEs: EVERSON, TODD M;MARSIT, CARMEN JOSEPH;STROUD, LAURA R (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: addiction;Address;adipokines;Affect;Anxiety;Architecture;Biological;biological adaptation to stress;Biological Assay;biomarker identification;Birth;Birth Weight;Brain;brain tissue;Cannabinoids;Cannabis;Cannabis sativa plant;Child Development;cohort;Collection;Communication;Data;design;Development;Drug usage;Endocannabinoids;Energy Metabolism;Environment;Epidemiologic Methods;Epigenetic Process;epigenetic regulation;Evaluation;fetal;Fetal Growth;fetal marijuana exposure;fetal tobacco exposure;functional genomics;Future;Gene Expression;gene network;Genes;Genetic Transcription;genome-wide;genomic profiles;genomic profiling;Genomics;Goals;Growth;Health;high risk population;Human;Immune;immune function;implantation;improved;in utero;Infant;Infant Development;infant outcome;Intervention;intrauterine environment;Investigation;Legal;Link;Marijuana;marijuana legalization;marijuana use;marijuana use in pregnancy;marijuana user;maternal marijuana use;Mediation;Medical;Messenger RNA;Metabolic;Methods;Methylation;MicroRNAs;miRNA expression profiling;Molecular;Molecular Target;Mothers;National Institute of Drug Abuse;neurobehavior;neurobehavioral;neuroblastoma cell;neurodevelopment;Neurologic;neuron development;Neurons;new therapeutic target;Newborn Infant;novel;offspring;Organ;Outcome;Pathway interactions;Perception;phenotypic data;Placenta;Play;posttranscriptional;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;prenatal influence;Prevalence;prospective;Regulation;Reporting;Research;Risk;Role;Safety;Sampling;Screening procedure;Seminal;Signal Pathway;Signal Transduction;sperm cell;Strategic Planning;Stress;substance use;Surgeon;System;Testing;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;trend;United States National Academy of Sciences;Untranslated RNA;Vascularization;Woman;Work

PROJECT_TITLE: Placental Genomics in the Developmental Consequences of Marijuana Use in Pregnancy

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE This project seeks to develop new computer algorithms for designing protein structures and predicting protein interactions. The rationally designed proteins that we create will have potential uses as molecular scaffolds in a wide range of biomedical applications including diagnostics and cellular therapies. By predicting the interactions between T cell receptors and antigens, we aim to better understand how the immune system discriminates self from non-self in the context of infectious and autoimmune disease and cancer.

PI_NAMEs: BRADLEY, PHILIP  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Adaptive Immune System;Algorithms;Autoimmune Diseases;Binding;Binding Sites;Bioinformatics;Biology;Catalytic Domain;Cell Therapy;Communicable Diseases;Complement;Complex;Computational algorithm;Data;design;Diagnostic;Diameter;Goals;Health;Human;Immune system;insight;Laboratories;lens;Machine Learning;Malignant Neoplasms;Molecular;Molecular Machines;molecular modeling;Organism;Peptide/MHC Complex;prediction algorithm;Process;Protein Engineering;protein folding;protein structure;Proteins;rapid growth;rational design;Research;scaffold;Signal Transduction;simulation;Specificity;structural biology;Structural Models;T-Cell Receptor;T-cell receptor repertoire;Tandem Repeat Sequences;Techniques;Time;tool;Work

PROJECT_TITLE: Molecular modeling and machine learning for protein structures and interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Rehabilitation;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE This award will enable the candidate to accelerate her independent patient-oriented alcohol research program and to significantly expand her commitment to effective mentoring. Engaging the integrated career development, mentoring, and research plans will help the candidate and her mentees to advance the science of alcohol-related intimate partner violence and to develop novel trauma-informed intervention pathways.

PI_NAMEs: FLANAGAN, JULIANNE CHRISTINA (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Acceleration;Acute;Address;Adult;Affect;Aggressive behavior;Alcohol abuse;alcohol abuse therapy;alcohol consequences;Alcohol consumption;alcohol effect;alcohol misuse;alcohol research;alcohol use disorder;Alcoholic Intoxication;Alcohols;Area;Award;Behavioral;Biological;Biological Markers;breath alcohol measurement;career;career development;Cellular Phone;Chronic;Clinical;Clinical Sciences;Complement;Conflict (Psychology);Consultations;coping;cost;Couples;Data;Data Analyses;design;Development;Diagnosis;Diagnostic;Distress;Dose;drinking;Ecological momentary assessment;Economic Burden;Emotional;Enrollment;Ensure;equity, diversity, and inclusion;Event;experience;Family;Future;Goals;Health;heart rate variability;Heavy Drinking;Individual;Influentials;information processing;innovation;interest;Intervention;intimate partner violence;Intoxication;Investigation;Investments;K-Series Research Career Programs;Laboratories;Leadership;Literature;Longevity;Measurement;Measures;Mentors;Mentorship;Modality;Modeling;Morbidity - disease rate;mortality;multimodality;National Institute on Alcohol Abuse and Alcoholism;next generation;novel;Onset of illness;Oral;Outcome;Participant;partner aggression;Pathway interactions;patient oriented;patient oriented research;Patient Self-Report;Perception;Physiological;Population;Post-Traumatic Stress Disorders;Prevention;programs;Psychophysiology;Public Health;Qualifying;Recording of previous events;Reporting;Research;Research Personnel;Research Project Grants;Resources;response;Risk;Role;Science;secondary analysis;Series;Severities;skills;social;sound;Standardization;Strategic Planning;symptomatology;Symptoms;theories;Time;Training;Trauma;Treatment outcome;Violence;Work

PROJECT_TITLE: Advancing Couple and Family Alcohol Treatment through Patient-Oriented Research and Mentorship

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Kidney Disease;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative This is an Academic-Industrial partnership project between scientists at the University of Texas Southwestern Medical Center and Philips Research Hamburg and Philips North America. The partnership has been formed with the goal of translating a novel molecular Magnetic Resonance Imaging (MRI) method, Chemical Exchange Saturation Transfer (CEST), into a reliable imaging technology for the characterization of Small Renal Masses (SRMs). Achieving this goal will allow improved diagnosis, prognosis and treatment, will cut unnecessary biopsies and complications, thus improving patient outcomes and decreasing treatment financial and psychological burden.

PI_NAMEs: DIMITROV, IVAN E;KEUPP, JOCHEN ;PEDROSA, IVAN ;VINOGRADOV, ELENA  (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: Abdomen;Ablation;Academia;Acceleration;Accounting;Address;Adopted;Algorithms;anatomic imaging;Benign;Biological Markers;Biopsy;breast lesion;Chemicals;Clear cell renal cell carcinoma;Clinical;Clinical Assessment Tool;clinical center;Clinical Research;clinical translation;cohort;Collaborations;Complication;Contrast Media;Death Rate;Deposition;Detection;Development;Diagnosis;Early Diagnosis;Elements;Evaluation;Exposure to;Fatty acid glycerol esters;Glycogen;Goals;Histologic;Histology;Histopathology;Human;Image;Imaging Device;imaging modality;Imaging technology;Immunohistochemistry;improved;in vivo;Incidence;Indolent;Industry;industry partner;Injections;Kidney;kidney imaging;Knowledge;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Neoplasms;Maps;Measurement;Medical center;men;Metabolic;Methodology;Methods;Molecular;Morbidity - disease rate;Motion;neuro-oncology;non-invasive imaging;North America;novel;Oncology;Operative Surgical Procedures;overtreatment;Oxyphilic Adenoma;Patient-Focused Outcomes;Patients;Perfusion;preclinical study;predictive marker;Predictive Value;Procedures;Prognosis;programs;Protocols documentation;psychologic;Publications;recruit;Renal Carcinoma;Renal Cell Carcinoma;Renal Mass;Reporting;Research;Research Personnel;Resolution;respiratory;risk stratification;Role;Scientist;Signal Transduction;soft tissue;Specialized Program of Research Excellence;Spectrum Analysis;Stratification;Structure;success;System;Techniques;Technology;Technology Transfer;Texas;Tissues;tool;Translating;Translations;treatment effect;tumor;tumor microenvironment;Universities;virtual biopsy;Woman

PROJECT_TITLE: Chemical Exchange Saturation Transfer (CEST) MRI for the Characterization Small Renal Masses


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Hematology;Rare Diseases;Women's Health Research

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Our proposal utilizes mouse genetic, live-cell imaging, flow cytometry, biochemistry, and molecular biology approach to identify 1) the mechanism that regulates the recruitment and disassociation of PARP2 from the DNA damage sites, 2) the impact of trapped PARP2 on DNA repair and DNA replication, 3) the effects of PARylation/MARylation defective PARP2 on erythropoiesis, hematopoiesis, Trp53/CHK2 mediated clonal expansion. The ultimate goal is to understand the newly identify structural role of PARP2 in hematopoiesis and cancer therapy and to mitigate the on-target bone marrow toxicities of clinical PARP inhibitors.

PI_NAMEs: ZHA, SHAN  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;ADP Ribose Transferases;ADP ribosylation;Adult;Affect;Affinity;Anemia;Animals;Base Excision Repairs;Binding;Binding Proteins;Biochemical;Biochemistry;Biological Assay;Bone Marrow;BRCA deficient;brca gene;BRCA1 gene;BRCA2 gene;cancer cell;Cancer Patient;cancer therapy;Cells;Cellular biology;Charge;CHEK2 gene;chemotherapy;Chromatin;Chronic;Cisplatin;Clinical;Clonal Expansion;Defect;Development;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA lesion;DNA Ligases;DNA Repair;DNA Repair Gene;Dose;Dysplasia;effective therapy;Embryo;Erythropoiesis;Flow Cytometry;Fluorescence;Genes;Genetic Epistasis;Goals;Hematopoiesis;Hematopoietic;Histones;Impairment;In Vitro;in vivo;inhibitor;Knock-in;Lasers;Ligase;Ligation;Link;live cell imaging;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Mediating;Modeling;Molecular Biology;mouse genetics;mouse model;Mus;Mutation;Myelogenous;novel;Okazaki fragments;Patients;Photobleaching;Physical condensation;Poly Adenosine Diphosphate Ribose;Poly(ADP-ribose) Polymerase Inhibitor;premature;prevent;Proteins;recruit;Relaxation;repaired;Risk;Role;S phase;Site;Specificity;Splenomegaly;Testing;Toxic effect;TP53 gene;Withdrawal;XRCC1 gene

PROJECT_TITLE: The non-catalytic function of PARP2 in DNA repair and cancer therapy


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative This proposed research develops novel multiplexing technologies to lower the cost and increase the accuracy and speed of high-throughput analysis. Therefore, the outcome of this project has the potential to facilitate biomedical investigations to advance our knowledge on diseases and develop new drugs.

PI_NAMEs: YUN, SEOK-HYUN ANDY (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: Antibodies;Bar Codes;Binding;Biological;Biological Assay;Cell surface;Cell Survival;Cells;Characteristics;Color;combinatorial;cost;cytokine;Data;data acquisition;Development;Disease;DNA;drug candidate;drug development;drug discovery;efficacy evaluation;Event;Flow Cytometry;Fluorescence;Future;Genes;Goals;high throughput analysis;high throughput screening;high throughput technology;Hydrogels;Immunoassay;Immunotherapy;Industry Standard;Investigation;Knowledge;Lasers;Lead;Libraries;Light;Measures;meter;Methods;Microfluidics;Microspheres;new technology;novel;novel therapeutics;Optics;Outcome;particle;Pathway interactions;Peptide Hydrolases;Pharmaceutical Preparations;Phenotype;Polystyrenes;Probability;Process;Readability;Reagent;Research;Resort;Sampling;screening;screening program;Semiconductors;Sorting;Speed;Surface;Technology;Time;tool;Toxic effect

PROJECT_TITLE: Multi-color laser particles for high-throughput pooled analysis

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: Project Narrative Mutations can be small single nucleotide polymorphisms (SNPs) altering a single DNA base or they can be larger structural variants (SVs) involving the duplication or deletion of large segments of DNA. SV mutations can underlie human diseases and disorders but we know little about the frequency with which SV mutations arise, the evolutionary forces that act on SV mutations, and how they influence evolutionary change. This work will improve the accuracy of model organism-based investigations of human diseases and developmental disorders by discovering the frequency with which SVs are generated in different populations, studying how population genetic forces act on SVs and examining how SVs diverge across the tree of life.

PI_NAMEs: FIERST, JANNA LYNN (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Affect;base;Biology;Centromere;Chromosomal Rearrangement;Chromosomes;comparative;comparative genomics;Copy Number Polymorphism;developmental disease;Diffuse;Disease;DNA;DNA sequencing;Evolution;Frequencies;Genetic Population Study;Genetic Recombination;Genetic Variation;Genome;genomic variation;Genomics;Graph;human disease;improved;innovation;Investigation;Length;Life;model organism;Molecular;Mutation;Natural Selections;Organism;Outcome;Phylogenetic Analysis;Population;Population Genetics;Prevalence;programs;Research;segregation;Single Nucleotide Polymorphism;Source;Structural Models;Technology;Testing;theories;Time;Trees;Variant;Work

PROJECT_TITLE: Structural variants and the locus of evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Transplantation;Wound Healing and Care

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: Medical implants will benefit from materials with inherent ability to promote angiogenesis and reduce oxidative stress associated with inflammation caused by the surgery and the presence of a foreign body. We will invent a series of biodegradable metallo-elastomers that can mimic the activity of metalloenzymes to achieve angiogenesis and anti-inflammation.

PI_NAMEs: WANG, YADONG  (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Active Sites;Amino Acids;angiogenesis;Angiogenic Factor;Antiinflammatory Effect;Apligraf;Area;Beds;Benchmarking;Binding;Biocompatible Materials;biological systems;biomaterial compatibility;Blood Vessels;Clinical;Collagen;Copper;covalent bond;crosslink;density;design;Dose;Effectiveness;Elasticity;elastomeric;Elastomers;Endothelium;Engineered skin;Engineering;Enzymes;Equilibrium;Exhibits;Extracellular Matrix;Family;FDA approved;Fibrosis;first-in-human;Foreign Bodies;Formulation;Gel;Graft Survival;Growth Factor;healing;Histidine;Implant;improved;In Vitro;in vivo;Inflammation;invention;Ions;Knowledge;Ligands;medical implant;metalloenzyme;Metals;mimetics;Modeling;Mus;novel;Operative Surgical Procedures;Oxidation-Reduction;Oxidative Stress;polycaprolactone;Polymers;Pre-Clinical Model;Process;Property;Proteins;Reactive Oxygen Species;Research;research clinical testing;response;Schiff Bases;Series;Skin;Skin graft;Skin wound healing;soft tissue;Specific qualifier value;Structure;Structure-Activity Relationship;Subgroup;success;Superoxide Dismutase;Superoxides;Testing;tissue regeneration;tissue repair;Tissues;Toxic effect;Transition Elements;Tube;validation studies;Variant;Vascular Endothelial Growth Factors;Vertebral column

PROJECT_TITLE: Biodegradable metallo-elastomer

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative  Vascular disease resulting from hypertension is a leading health problem in the US; yet, it remains unknown how hypertensive changes in the composition of vessel extracellular matrix (ECM) and mechanical properties regulate receptor trafficking and vascular reactivity. There is a critical need to develop an engineering platform capable of patterning ECM structure, composition, and cellular alignment in 3D to build a perfusable vascular network with native biomechanical properties to investigate the interplay between biomechanical forces and biochemical signaling in hypertensive vascular disease. This proposal will use FRESH 3D bioprinting and a newly developed biomechanical strain sensor to 3D bioprint a functional resistance artery and create an ECM- based vascular microfluidic platform to improve our understanding of hypertensive disease progression.

PI_NAMEs: SHIWARSKI, DANIEL J (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3-Dimensional;3D Print;Adrenergic Agents;Adult;Advisory Committees;Affect;American;Anisotropy;Arteries;Binding;Biochemical;bioink;Biology;biomechanical test;Biomechanics;bioprinting;Biosensor;blood pressure elevation;blood pressure reduction;Blood Vessels;Calcium Signaling;career;career development;cell dedifferentiation;Cell Differentiation process;Cell Physiology;Cells;Cessation of life;Collagen;Collagen Type IV;Complex;Cues;Custom;Deposition;design;Development;Development Plans;Diameter;Disease;disease model;Disease Progression;Drug Screening;Endothelial Cells;Endothelium;Engineering;Extracellular Matrix;Extracellular Matrix Proteins;fabrication;Fibronectins;fluid flow;Fluorescence;fluorescence imaging;Fluorescence Microscopy;Foundations;G-Protein-Coupled Receptors;Geometry;Goals;Growth Factor;Health;Health Care Costs;Hydrogels;Hypertension;hypertensive;Image Analysis;Impairment;improved;in vivo;Institute of Medicine (U.S.);Investigation;Knowledge;Laminin;Legal patent;Maps;Measures;mechanical properties;Mechanics;Mediating;Mentors;meter;Microfluidic Microchips;Microfluidics;Modeling;Molecular;Molecular and Cellular Biology;molecular pathology;monolayer;Morbidity - disease rate;mortality;Mus;nanomechanics;new technology;novel;Optical Coherence Tomography;organ on a chip;Pathologic;Pattern;Perfusion;Persons;pharmacologic;Pharmacological Treatment;Phase;Phenotype;Physiological;Population;pressure;Printing;Production;Property;Proteomics;Pulsatile Flow;Qualifying;quantitative imaging;receptor;Receptor Signaling;Research;Resistance;Resource Development;response;Risk Factors;sensor;Signal Transduction;Silicones;Smooth Muscle Myocytes;Stimulus;Structure;System;Technology;Testing;three dimensional structure;Time;Tissue Engineering;tissue support frame;Tissues;tool;trafficking;Training;Tunica Adventitia;Tunica Intima;Universities;Vascular Diseases;Vascular Endothelial Growth Factors;Vascular Smooth Muscle;vascular smooth muscle cell proliferation;vascular tissue engineering;Vascularization;vasoconstriction;Work

PROJECT_TITLE: Development of a Collagen-based 3D Bioprinted Microfluidic Platform for Vascular Tissue Engineering and Disease Modeling

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Clinical Research;Diabetes;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE This project seeks to develop more accurate models that predict the risk of repeat hospitalizations among patients with diabetes. The models will be programmed into a tool that will be integrated with an electronic health record system and automatically predict the re-hospitalization risk of patients. Such a tool could be used to identify higher risk diabetes patients more likely to benefit from intervention, thus improving care and reducing costs.

PI_NAMEs: RUBIN, DANIEL J (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, JEAN M

PROJECT_TERMS: Admission activity;Caring;Clinical;Clinical Data;Clinical Pathways;clinical practice;Clinical Research;cohort;Collection;comorbidity;comorbidity Index;Complement;cost;cost outcomes;Data;Data Set;deep learning;demographics;Dependence;design;Diabetes Mellitus;diabetes risk;Electronic Health Record;electronic health record system;experience;Goals;high risk;hospital readmission;Hospitalization;Hospitals;improved;individual patient;Institution;Insulin;Intervention;Laboratories;Length of Stay;Machine Learning;Manuals;member;model development;model generalizability;Modeling;Participant;patient oriented;Patient Readmission;patient subsets;Patients;Pharmaceutical Preparations;point of care;predictive modeling;predictive tools;prospective;Publishing;readmission risk;Recording of previous events;Research;Risk;Risk Factors;risk prediction;risk prediction model;sociodemographics;statistics;Techniques;Testing;tool;Translating;Translations;Validation;Work

PROJECT_TITLE: Developing and validating EHR-integrated readmission risk prediction models for hospitalized patients with diabetes

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]