PI_NAMEs: REIN, ALAN  (contact)

PROJECT_TERMS: Affinity;Anti-viral Therapy;Area;Bacteriophages;C-terminal;Cell Nucleus;Cells;Charge;Cultured Cells;Cytoplasm;Data;density;design;dimer;Dimerization;DNA;DNA biosynthesis;Fluorometry;gag Gene Products;Gammaretrovirus;Goals;HIV-1;Impairment;In Vitro;in vivo;Infection;Interphase;Interphase Cell;Isoleucine;Lentivirus;Leucine Zippers;member;Mitosis;Molecular;Molecular Analysis;Moloney Leukemia Virus;Murine leukemia virus;Nuclear Envelope;Nucleocapsid;particle;Penetration;Phytic Acid;Proteins;Recombinants;Reporting;Research;Retroviridae;Role;Scanning;Structure;Viral;Viral Proteins;viral RNA;Virion;Virus Assembly;virus core;Virus Replication

PROJECT_TITLE: Retrovirus Assembly and Maturation


ACTIVITY: ZIA

ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_NAME: DIVISION OF BASIC SCIENCES - NCI

PROJECT_TERMS: Affinity;Anti-viral Therapy;Binding;Binding Proteins;cofactor;DNA;Elements;gag Gene Products;genomic RNA;Goals;HIV-1;Individual;instrument;Investigation;Kinetics;Knowledge;Measures;Messenger RNA;Microbiology;Molecular;Nucleic Acids;particle;Physiological;Proteins;Reverse Transcription;RNA;RNA-Protein Interaction;Role;Signal Transduction;Sodium Chloride;stem;Therapeutic Intervention;trend;Viral Packaging;viral RNA;Virion;Virus Replication

PROJECT_TITLE: Interactions of Retroviral Proteins with Nucleic Acids


PI_NAMEs: MILLER, ROBERT  (contact)

PROJECT_TITLE: Gated Optical Detectors-Dose Guided Radiotherapy


NIH_SPENDING_CATS: Breast Cancer;Cancer;Congenital Structural Anomalies;Pediatric;Prostate Cancer;Urologic Diseases;Women's Health Research

PI_NAMEs: LEWANDOSKI, MARK B (contact)

PROJECT_TERMS: Address;Adult;Area;Behavior;Biology;Bone Morphogenetic Proteins;breast cancer progression;Cells;Cellular biology;Data;Development;Disease;Elements;Embryo;Embryonic Development;Family;FGF5 gene;Fibroblast Growth Factor;Forelimb;Gastrointestinal Neoplasms;Gene Expression;Genetic;Goals;Growth;Heart;Hindlimb;Imagery;Limb Development;Limb structure;Malignant neoplasm of prostate;Malignant Neoplasms;Metastatic Neoplasm to the Bone;mutant;neglect;Normal Cell;Pathway interactions;Pattern;Pelvis;Protein Family;Publishing;Research;Role;scapula;Series;Signal Transduction;Signaling Molecule;Structure;tumor;Work

PROJECT_TITLE: Role of BMP and FGF signaling during limb development


PI_NAMEs: GREWAL, SHIVINDER S (contact)

PROJECT_TERMS: Affect;Anti-sense RNA;Biochemical;cancer therapy;Cell Cycle;Cell Physiology;Cells;Chromatin;Chromatin Modeling;Chromosome Structures;Complex;Coupled;Cues;Development;Double-Stranded RNA;Elements;Ensure;Epigenetic Process;Eukaryota;exosome;Fission Yeast;Foundations;Gametogenesis;Gene Expression Profile;Gene Silencing;Genes;Genetic;Genetic Recombination;Genetic Transcription;Genome;genome integrity;genome-wide;Heterochromatin;Histone H2A;Histone H3;human disease;insight;Introns;Investigation;Large-Scale Sequencing;Link;Location;Lysine;Maintenance;Maps;Measures;Mediating;Messenger RNA;Methylation;Modeling;Modification;novel;Pathway interactions;Play;Polyadenylation;Polycomb;posttranscriptional;preservation;prevent;Process;protein complex;Proteins;recruit;Regulation;Repression;Resolution;response;RNA;RNA Degradation;RNA Interference;RNA Polymerase II;RNA Splicing;Role;S phase;Signal Induction;Site;Small Interfering RNA;Small RNA;Structure;therapeutically effective;Transcript;Variant;Work

PROJECT_TITLE: RNAi and Epigenetic Control of Higher-Order Chromatin Assembly


NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Cancer;Genetics;HIV/AIDS;Infectious Diseases;Patient Safety;Prevention;Sexually Transmitted Infections;Topical Microbicides

PI_NAMEs: NICKLAUS, MARC  (contact)

PROJECT_TERMS: 3-Dimensional;AIDS therapy;Anti-HIV Agents;anti-HIV microbicide;Biological;Biological Assay;Biological Testing;Characteristics;Chemicals;Clinical Trials;Collection;comorbidity;Complex;Computer Assisted;Computing Methodologies;Custom;Data;Databases;design;Development;DNA;Docking;Drug Design;drug resistant virus;Drug toxicity;Enzyme Inhibitor Drugs;Enzymes;FDA approved;Genome;Goals;Grant;HIV;HIV drug resistance;HIV Integrase;HIV Integrase Inhibitors;HIV-1;HIV/AIDS;Homologous Gene;Homology Modeling;inhibitor;Integrase;Integrase Inhibitors;Joints;Knowledge;Leadership;Libraries;Life Cycle Stages;Ligands;Methods;microbicide;Modeling;Molecular;Molecular Target;Multi-Drug Resistance;new therapeutic target;novel;Pathogenesis;Patients;Peptide Hydrolases;Perception;Pharmaceutical Preparations;pharmacophore;Phenotype;protein expression;Proteins;Publishing;Replication-Associated Process;Retrieval;Reverse Transcriptase Inhibitors;RNA-Directed DNA Polymerase;Sampling;screening;Services;Side;Source;Structure;System;Therapeutic;Toxic effect;Viral;Virus Replication;Work

PROJECT_TITLE: HIV Integrase Modeling and Computer-Aided Inhibitor and Microbicide Development


NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Neurosciences;Women's Health Research

PI_NAMEs: STEEG, PATRICIA SCHRIVER (contact)

PROJECT_TERMS: Adverse event;Antibodies;Basement membrane;biocytin;Blood - brain barrier anatomy;Blood Vessels;blood-brain tumor barrier;Brain;Brain scan;breast cancer metastasis;Breast Cancer Patient;Collagen Type IV;Drainage procedure;drug development;Drug Exposure;ERBB2 gene;Experimental Models;Goals;Human;Image;Immunofluorescence Immunologic;Immunoglobulin G;improved;Laboratories;Laminin;Lesion;machine learning algorithm;Membrane Proteins;Metastatic breast cancer;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Leptomeninges;Molecular Analysis;mortality;mouse model;Mus;Neoplasm Metastasis;Neurocognitive;Pathway interactions;Patients;Penetration;Perfusion;Permeability;Pharmaceutical Preparations;Phase;pre-clinical;Reporting;Role;Site;small molecule;Stains;Testing;Therapeutic;Therapeutic antibodies;Time;Trastuzumab;uptake

PROJECT_TITLE: Molecular Analysis of Breast Cancer Metastasis to the Brain


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Precision Medicine;Prostate Cancer;Urologic Diseases

PI_NAMEs: FIGG, WILLIAM DOUGLAS (contact)

PROJECT_TERMS: Algorithms;androgen biosynthesis;androgen independent prostate cancer;Androgen Receptor;Androgens;angiogenesis;Animal Testing;Apoptosis;bench to bedside;Biology;cancer therapy;cBioPortal;Cell Line;chemotherapy;Clinic;clinical development;Clinical Pharmacology;clinically relevant;Combined Modality Therapy;Custom;Data;design;Development;Disease;DNA;DNA Repair;DNA Sequence Alteration;docetaxel;drug candidate;Drug Design;drug development;drug discovery;Drug Screening;efficacy evaluation;gene panel;Gene Targeting;Genetic;Genomics;Goals;inhibitor;interest;Laboratories;Lead;Malignant neoplasm of prostate;metastatic process;Modeling;Molecular;Monitor;Mutation;new therapeutic target;next generation;next generation sequencing;novel;novel therapeutics;Pathway interactions;patient population;Patient Selection;Pharmacology and Toxicology;PI3K/AKT;potential biomarker;pre-clinical;Pre-Clinical Model;precision medicine;preclinical development;Prediction of Response to Therapy;Process;Prognostic Marker;prostate cancer cell line;prostate cancer model;Provenge;PTEN gene;Regimen;Research;research clinical testing;Research Personnel;Resistance;resistance mechanism;screening;Signal Transduction;System;targeted treatment;Testing;Therapeutic;therapy resistant;tool;Translational Research;Treatment Failure;Treatment outcome;treatment response;tumor;Tumor Suppressor Genes;Validation;Work

PROJECT_TITLE: Drug Development for Prostate Cancer and other Metastatic Processes


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: ST CROIX, BRADLEY D (contact)

PROJECT_TERMS: angiogenesis;Angiogenesis Inhibitors;anti-cancer;Antibodies;Antibody-drug conjugates;Antineoplastic Agents;Binding;Blood;Blood Vessels;cancer therapy;Cell surface;Cells;chimeric antigen receptor T cells;Development;Endothelial Cells;Endothelium;Extracellular Domain;Growth;Human;Link;Modeling;Molecular Weight;Monitor;mouse model;Mus;Neoplasm Metastasis;Neoplasm Transplantation;Neoplasms in Vascular Tissue;neutralizing antibody;novel;Pharmaceutical Preparations;potential biomarker;pre-clinical;Property;protein biomarkers;response;screening;Sensitivity and Specificity;small molecule;Solid Neoplasm;targeted agent;Testing;translational study;tumor;Tumor Cell Line

PROJECT_TITLE: Targeting TEMs in Preclinical Tumor Models


NIH_SPENDING_CATS: Biotechnology;Cancer;Cervical Cancer;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

PI_NAMEs: LOWY, DOUGLAS R. (contact)

PROJECT_TERMS: Adjuvant;Affect;Animal Model;cancer risk;Cell Culture Techniques;Cervical;Communicable Diseases;Costa Rica;cross immunity;Disease;follow-up;gene transfer vector;Genes;genetic vaccine;Genotype;global health;Goals;Heterogeneity;Human papilloma virus 31;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;Immune;Infection;Intervention;Malignant Neoplasms;Mediating;Nucleotides;Papillomavirus;Persons;Pharmaceutical Preparations;Phylogenetic Analysis;Positioning Attribute;premalignant;prevent;Prevention;Proteins;Race;Therapeutic Agents;unvaccinated;Vaccinated;vaccine efficacy;vaccine evaluation;vaccine trial;Vaccines;Variant;vector;Virion;Virus;Woman

PROJECT_TITLE: Papillomavirus Virion Proteins and Vaccines


PI_NAMEs: PATHAK, VINAY K. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Alternative Splicing;Anti-viral Agents;Anti-viral Therapy;APOCEC3G gene;Binding;Biological;Biomedical Research;C-terminal;cancer type;Catalytic Domain;CD34 gene;Cell Cycle Arrest;Cells;cellular transduction;Collaborations;comparative;Complex;Cytidine;Cytidine Deaminase;Deamination;design;Development;Direct Repeats;DNA biosynthesis;DNA Integration;Epidemic;Evolution;Exons;Frequencies;gene therapy;Generations;Genes;Genetic;Goals;Hematopoietic stem cells;HIV;HIV-1;Homologous Protein;homologous recombination;Host Defense;Human;in vivo;Infection;inhibitor;insight;Knowledge;Laboratories;Lentivirus Vector;Malignant Neoplasms;Mediating;Membrane;Molecular;Mutagenesis;mutant;Mutation;Mutation Analysis;N-terminal;novel;novel therapeutic intervention;pathogen;Peptides;Pharmaceutical Preparations;PPP2R5A gene;PPP2R5B gene;Protein phosphatase;Proteins;Reagent;reconstitution;Research;Resistance;Reverse Transcription;RNA Splicing;Single-Stranded DNA;Somatic Mutation;Structure;Testing;translational genomics;Universities;vector;viral DNA;Viral Genome;Viral Physiology;Virion;Virus;Virus Inactivation;Virus Replication

PROJECT_TITLE: Structure and Function of Vif and APOBEC3 (A3) Proteins


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Infectious Diseases;Orphan Drug;Prostate Cancer;Rare Diseases;Sexually Transmitted Infections;Urologic Diseases;Vaccine Related

PI_NAMEs: SCHLOM, JEFFREY  (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Adverse effects;Aftercare;androgen independent prostate cancer;anti-PD-L1;anti-PD-L1 antibodies;anti-PD1 therapy;Antibodies;Antigen Presentation;antitumor effect;Appropriateness Review;Area;bevacizumab;Bicalutamide;Biochemical;Biopsy;Brachyury protein;Cancer Center;cancer immunotherapy;Cancer Patient;Cancer Vaccines;Castration;CCR;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Immunity;checkpoint inhibition;checkpoint therapy;Chimeric Proteins;Clinical;clinical predictors;Clinical Research;Clinical Treatment;Clinical Trials;cohort;Combined Modality Therapy;Complete Blood Count;cytokine;Cytotoxic T-Lymphocytes;cytotoxicity;Dendritic Cells;design;Development;DNA;Dose;Evolution;Extramural Activities;first-in-human;Flutamide;Frequencies;Future;Goals;Histones;Human;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;IgG1;IL8 gene;Immune;immune activation;Immune checkpoint inhibitor;Immune response;Immune system;Immunooncology;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;Inflammatory;insight;Interferon Type II;Interleukin-12;Interleukin-12 therapy;intravenous administration;Joints;Link;Lymphocyte;Macrophage;Malignant neoplasm of prostate;Maximum Tolerated Dose;men;Mesenchymal Cell Neoplasm;metastatic colorectal;Metformin;Modeling;monocyte;mouse model;Mus;Myeloid-derived suppressor cells;Natural Killer Cells;Necrosis;Neoplasm Metastasis;neutrophil;Non-Small-Cell Lung Carcinoma;Nonmetastatic;novel;Obesity;open label;Overweight;patient subsets;Patients;Peripheral;peripheral blood;Phase;phase 1 study;phase 2 study;phase I trial;phase II trial;Phenotype;Plasma;pre-clinical;preclinical study;Preparation;Production;prognostic;programmed cell death protein 1;Proliferating;Protocols documentation;Randomized;Recombinants;Recurrence;Refractory;Regimen;Reporting;Research Personnel;Resistance;response;Schedule;Science;Serum;Solid Neoplasm;subcutaneous;T cell response;T-Lymphocyte;TGFB1 gene;Therapeutic;Thymus Epithelial Neoplasm;Time;TNF gene;Transforming Growth Factor beta;treatment effect;Treatment Protocols;tumor;Tumor Antigens;tumor microenvironment;Tumor-associated macrophages;Vaccines

PROJECT_TITLE: Human Immune Responses to Tumor Antigens for Cancer Immunotherapy


NIH_SPENDING_CATS: Cancer

PI_NAMEs: XIA, DI S (contact)

PROJECT_TERMS: Address;Atomic Force Microscopy;ATP Hydrolysis;ATP phosphohydrolase;ATPase Domain;Back;Binding;Biochemical;Biological;Cancer cell line;cancer therapy;Cell Cycle Regulation;Cell Physiology;Cells;Clinical;Clinical Research;cofactor;Collaborations;Complex;Contracts;Coupled;Coupling;density;Deubiquitination;Devices;Disease;DNA biosynthesis;drug development;Electron Microscopy;Electron Transport Complex III;extracellular;Extravasation;Family;Goals;Hand;Homo;Human;Inclusion Body Myopathy with Early-Onset Paget Disease;Induction of Apoptosis;inhibitor;Inner mitochondrial membrane;insight;Iron-Sulfur Proteins;Kinetics;life span;Link;Location;medical schools;Membrane;Membrane Fusion;Membrane Fusion Activity;Membrane Proteins;Merozoite Surface Protein 1;Mitochondria;Mitochondrial Matrix;mitochondrial membrane;Mitochondrial Proteins;Molecular Conformation;Molecular Machines;Motion;Mus;Mutagenesis;mutant;Mutation;Myopathy;Neurodegenerative Disorders;Nucleic Acids;Nucleotides;Organelles;Pharmaceutical Preparations;Play;prevent;Process;protein complex;protein degradation;protein folding;Protein Subunits;Protein translocation;Proteins;Protons;Quality Control;Reaction;Regulation;Research;respiratory;Respiratory Process;Role;Scanning;seal;segregation;Speed;stress management;Structure;translocase;Ubiquitination;unfoldase;valosin-containing protein;Visualization;Work;Yeasts

PROJECT_TITLE: AAA Proteins, Mechanisms of Their Functions and Related Diseases


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

PI_NAMEs: AMBS, STEFAN  (contact)

PROJECT_TERMS: Acids;Address;Affect;African;African American;African American population;African ancestry;American;Anti-Inflammatory Agents;Antibodies;Area;Aspirin;Bacteriophages;Biological Assay;Blood;Blood specimen;blood-based biomarker;cancer health disparity;Case/Control Studies;Censuses;Chromosomes;CLIA certified;clinical diagnosis;cohort;Cohort Studies;Collaborations;Communication;Communities;Data;data integration;Death Rate;deprivation;Detection;Development;Disease;disease disparity;Disseminated Malignant Neoplasm;Environment;environmental agent;Epigenetic Process;Ethnic Population;European;experience;Fatty Acid Desaturases;Fatty Acids;follow-up;Future;Genetic;genetic association;Genetic Predisposition to Disease;genetic signature;genetic variant;genome wide association study;genome-wide;genomic locus;Geographic Locations;Germ Lines;Ghana;Goals;Human;human virome;Immune;immune function;Immune response;Immunobiology;Immunomodulators;Immunooncology;Immunosuppression;Incidence;indexing;Indigenous;Individual Adjustment;Infection;Inflammation;Inflammatory;inflammatory marker;Integration Host Factors;Interferons;Knowledge;lifestyle factors;Link;liver cancer patient;Localized Disease;Low income;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Maryland;Mass Spectrum Analysis;Medicine;men;men's group;Methods;mimicry;Minor;Mission;Molecular Profiling;mortality;Nature;neighborhood association;Neighborhoods;new technology;novel;Omega-3 Fatty Acids;Omega-6 Fatty Acids;Outcome;pathogen;Pathology;Pathway interactions;Patients;Peptide Library;Pharmaceutical Preparations;Pollution;Population;Population Control;Population Group;Population Heterogeneity;prevent;programs;Prospective cohort;prostate cancer progression;prostate cancer risk;Prostatic Neoplasms;Proteome;proteomic signature;Publishing;racial population;Recording of previous events;recruit;Recurrent disease;Reduce health disparities;Reporting;Research;research study;Residencies;Resources;Risk;Risk Factors;Role;Seroprevalences;Serum;Signal Transduction;Social Environment;Socioeconomic Status;Stress;Subgroup;Surveys;Survival Analysis;Therapeutic;Thromboxane A2;Tobago;trait;Trans Fatty Acids;tumor;Tumor Biology;Tumor Immunity;Tumor Suppression;United States;Variant;Viral;virome;Virus;Virus Diseases;West Indies

PROJECT_TITLE: The Molecular Profile of Prostate Tumors in African-American Men


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Human Genome;Immunotherapy;Patient Safety;Precision Medicine;Prostate Cancer;Urologic Diseases

PROJECT_TERMS: ABCB1 gene;ABCG2 gene;abiraterone;absorption;Adverse reactions;Affect;Age;Alleles;androgen deprivation therapy;anti-epileptic agents;Anti-Retroviral Agents;Antineoplastic Agents;Azathioprine;bevacizumab;Biological;cancer therapy;Candidate Disease Gene;Carboplatin;Central Nervous System;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;clinical center;CYP1B1 gene;CYP2C19 gene;CYP2D6 gene;CYP3A4 gene;CYP3A5 gene;Development;Differentiation Antigens;Disease;docetaxel;drug development;drug disposition;Drug Kinetics;drug metabolism;Drug Targeting;Drug Transport;Enzymes;Etiology;experimental study;Gender;Genes;Genetic;genetic association;Genetic Determinism;Genetic Markers;Genetic Polymorphism;genetic variant;Genetic Variation;Genotype;Gleason Grade for Prostate Cancer;GNRH2 gene;Goals;HLA Antigens;Hyperplasia;Immune;Immunofluorescence Immunologic;Immunoglobulins;Immunosuppressive Agents;Individual Differences;Inherited;inter-individual variation;interest;Killer Cells;Knowledge;Laboratories;lenalidomide;Link;Local Therapy;Malignant neoplasm of prostate;Malignant Neoplasms;Mammals;Mediating;Membrane;Metabolism;Molecular;Movement;Multivariate Analysis;Mutation;neoplastic;Normal tissue morphology;novel;Organ;Outcome;Paclitaxel;Pathway interactions;patient response;Patients;peptide hormone;Peripheral;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacogenetics;Pharmacogenomics;Pharmacological Treatment;Pharmacotherapy;Phenotype;Physiology;Plicamycin;Population;precision medicine;predicting response;Process;programs;Progression-Free Survivals;Prostate;Prostatic hypertrophy;receptor;Research;response;Scanning;Serum;side effect;Testosterone;Therapeutic;Therapeutic Index;therapeutic protein;therapy outcome;Tissue Microarray;Tissues;Toxic effect;Treatment outcome;treatment response;UGT1A1 gene;United States National Institutes of Health;Variant;Work;Xenobiotics

PROJECT_TITLE: Clinical Pharmacogenetics


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Prostate Cancer;Urologic Diseases

PI_NAMEs: CHOYKE, PETER L (contact)

PROJECT_TERMS: Ablation;Affect;American;androgen deprivation therapy;androgen independent prostate cancer;Area;Artificial Intelligence;Biopsy;blind;bone imaging;Cancer Etiology;cancer imaging;cancer recurrence;Cessation of life;clinically significant;Collaborations;Diagnosis;Disease;Focused Ultrasound Therapy;FOLH1 gene;Genomics;Goals;histological specimens;Image;Image Guided Biopsy;imaging modality;Implant;improved;Lasers;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metastatic Neoplasm to the Bone;Methods;Natural History;novel;Operative Surgical Procedures;Pathology;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physicians;Positron-Emission Tomography;preservation;prognostic;prognostication;Prostate;prostate biopsy;Prostate Cancer therapy;Protocols documentation;Radiation;radiologist;Reader;Reproducibility;Salivary duct structure;Salivary Glands;Scanning;Screening for Prostate Cancer;Skin Cancer;Sodium Fluoride;Staging;standard of care;targeted agent;Techniques;Testing;Treatment Side Effects;tumor;uptake

PROJECT_TITLE: Prostate Cancer Imaging


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Hematology;Immunotherapy;Prostate Cancer;Rare Diseases;Urologic Diseases

PROJECT_TERMS: Adjuvant Study;Adrenal Gland Neoplasms;Aftercare;Amino Acids;analog;Beds;Biopsy;Blocking Antibodies;bone imaging;CD276 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;chemokine;Clinic;Collaborations;CXCL9 gene;CXCR4 gene;Detection;Disease;Early Diagnosis;Endocrine Gland Neoplasms;fibroblast-activating factor;Fibroblasts;FOLH1 gene;Growth Factor;Head and Neck Cancer;Image;imaging agent;imaging probe;immune activation;Immunotherapy;interest;Isotopes;Label;Leucine;Ligand Binding;Logic;Lutetium;Malignant neoplasm of prostate;Malignant Neoplasms;molecular imaging;Multiple Myeloma;Neoadjuvant Therapy;Newly Diagnosed;Pancreas;Patients;Pattern;photoimmunotherapy;Pituitary Gland;pre-clinical;prostate cancer cell;Recurrence;Regulatory T-Lymphocyte;Research;response;Risk;Scanning;Serum;small molecule;Solid Neoplasm;T-Cell Activation;T-Lymphocyte;targeted agent;Technology;Testing;theranostics;Therapeutic;Thromboplastin;tissue biomarkers;Translating;tumor;tumor diagnosis;Universities;Work;X-Ray Computed Tomography

PROJECT_TITLE: Growth Factor Imaging and Photoimmunotherapy


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PROJECT_TERMS: Affect;Affinity;Area;Binding;Blood Vessels;Bone Marrow Transplantation;cancer cell;cell killing;Cell surface;Cell Therapy;Cells;Collaborations;constriction;design;Development;Dose;Endothelial Cells;Evaluation;experimental study;Fluorescence;Galactose;galactose receptor;Human;Image;Immune;immunoreaction;Immunotherapy;improved;in vivo;in vivo imaging;Interferon Type II;Ischemia;Label;Lesion;Magnetic Resonance Imaging;Malignant neoplasm of ovary;Mesenchymal Stem Cells;method development;Methods;Modeling;molecular imaging;Molecular Probes;Myocardium;neoplastic cell;nonhuman primate;Normal Cell;Normal tissue morphology;optical imaging;Optics;Permeability;Positron-Emission Tomography;Research;Resolution;response;Route;single photon emission computed tomography;stem cells;T-Lymphocyte;Therapeutic Agents;Time;Translating;tumor;tumor microenvironment;Work

PROJECT_TITLE: Cellular In vivo Imaging


NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Immunization;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Vaccine Related;Women's Health Research

PI_NAMEs: HODGE, JAMES  (contact)

PROJECT_TERMS: adaptive immunity;Breast;CD8-Positive T-Lymphocytes;chemotherapeutic agent;Cisplatin;Clinical Research;Colorectal;Colorectal Cancer;Combination Drug Therapy;Combined Modality Therapy;Combined Vaccines;Data;design;docetaxel;Down-Regulation;Gene Expression Regulation;Goals;Human;immune checkpoint;improved;in vivo;Interleukin-12;Knock-out;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;MC38;Mediating;Modeling;Mus;Myeloid Cells;Natural Immunity;Necrosis;Necrosis Induction;Pre-Clinical Model;programmed cell death ligand 1;Prostate Cancer therapy;Recombinants;Refractory;Signal Transduction;small molecule inhibitor;T cell response;Therapeutic Effect;transcriptomics;tumor;tumor growth;Tumor Promotion;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;Up-Regulation;Vaccines;vector;Vinorelbine

PROJECT_TITLE: Vaccine and Drug Combination Therapy for Human Cancers


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Liver Cancer;Liver Disease;Lung;Lung Cancer;Orphan Drug;Prostate Cancer;Radiation Oncology;Rare Diseases;Sexually Transmitted Infections;Urologic Diseases;Vaccine Related

PI_NAMEs: GULLEY, JAMES L. (contact)

PROJECT_TERMS: Acceleration;anti-PD-L1;anti-PD-L1 antibodies;Antibodies;antibody-dependent cell cytotoxicity;Antigen Targeting;Area;Biliary Tract Cancer;Binding;Brachyury protein;cancer cell;cancer immunotherapy;Cancer Patient;Cancer Vaccines;CCR;Cell Physiology;Cell Therapy;Cells;checkpoint modulation;chimeric antigen receptor T cells;Clinic;Clinical;Clinical Data;clinical development;clinical translation;Clinical Trials;cohort;Collaborations;Colorectal Cancer;Combination immunotherapy;Combined Modality Therapy;Combined Vaccines;Conduct Clinical Trials;Data;design;Disease;Enrollment;Epithelium;FDA approved;first-in-human;Goals;Human;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;human study;IL8 gene;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immune response;immune stimulatory agent;Immune system;immunogenic;Immunologics;Immunooncology;immunoregulation;Immunotherapy;improved;Industry Collaboration;Infiltration;innovation;interest;Interleukin-12;Interleukin-2;International;international center;Intervention;Intravenous;Laboratories;Laboratory Finding;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Mediating;Merkel cell carcinoma;Modality;Mucin 1 protein;Natural Killer Cells;Neoadjuvant Study;novel;objective response rate;Orphan Drugs;Pathologist;Pathway interactions;Patient Selection;Patients;peripheral blood;Phase;phase 2 study;phase 3 study;Play;Poxviridae;pre-clinical;Pre-Clinical Model;programmed cell death ligand 1;programmed cell death protein 1;Prostate Cancer Vaccine;Proteins;Radiation Oncologist;radiologist;Randomized;Recombinant Vaccines;refractory cancer;Renal Cell Carcinoma;Research;research clinical testing;Research Personnel;response;Role;Route;Safety;safety study;Scientist;side effect;Signal Transduction;subcutaneous;Surgeon;symposium;T-cell inflamed;T-Cell Receptor;T-Lymphocyte;targeted agent;targeted cancer therapy;Testing;therapy design;Tissues;Transforming Growth Factor beta;tumor;Tumor Antigens;tumor microenvironment;vaccine strategy;vaccine trial;Vaccines;Yeasts

PROJECT_TITLE: Cancer Immunotherapy


PROJECT_TERMS: animal imaging;Animals;Architecture;Area;Basic Science;Biodistribution;cancer therapy;Charge;Chemicals;clinical diagnostics;Clinical Trials;Code;computerized data processing;cost;Custom;design;Detection;detector;Development;Devices;Disease;drug development;Electronics;Evaluation;Event;flexibility;Future;Gamma Cameras;Gamma Rays;Goals;Growth;Human;human subject;Image;image reconstruction;Imaging Device;imaging system;Imaging technology;improved;instrumentation;Label;Laboratory Animals;Light;magnetic field;Magnetic Resonance Imaging;Measurement;microPET;microSPECT;Mission;molecular imaging;Mus;Names;National Cancer Institute;news;novel;Nuclear;nuclear imaging;optical imaging;Pathway interactions;photomultiplier;Photons;portability;Positioning Attribute;Positron;Positron-Emission Tomography;programs;Radioisotopes;Radionuclide Imaging;Research;Research Personnel;Scanning;Scientist;Side;simulation software;single photon emission computed tomography;Speed;Structure;Support Groups;System;Systems Development;Technology;Testing;thallium-doped sodium iodide;Time;tomography;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Instrumentation for microSPECT and microPET imaging


NIH_SPENDING_CATS: Cancer;Genetics;Radiation Oncology

PI_NAMEs: COLEMAN, NORMAN  (contact)

PROJECT_TERMS: Aftercare;biodosimetry;Biological;Biological Markers;cell killing;Cell Survival;chemoradiation;Clinic;Clinical;Combined Modality Therapy;Data;Dose;Drug Design;Drug usage;Endothelial Cells;Epigenetic Process;Exposure to;fractionated radiation;Gene Expression;Genes;Growth;Heat-Shock Proteins 90;image guided radiation therapy;Immunotherapy;In Vitro;in vivo;inhibitor;Intensity-Modulated Radiotherapy;Laboratories;mass casualty;metabolomics;MicroRNAs;Miniature Swine;Molecular;Molecular Target;Normal tissue morphology;Ontology;Pathway interactions;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Population Heterogeneity;Proteomics;Radiation;Radiation Dose Unit;Radiation Oncology;Radiation therapy;response;survival prediction;targeted agent;targeted treatment;Technology;Testing;tissue injury;Treatment Efficacy;Treatment Protocols;tumor;Update

PROJECT_TITLE: Radiation-induced molecular targets


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Infectious Diseases

PI_NAMEs: BOSSELUT, REMY  (contact)

PROJECT_TERMS: Address;Affinity;Aging;Allergens;Antigen Presentation;Antigen Receptors;Antigen Targeting;Antigens;Binding;Biochemical;Bone Marrow Transplantation;Cancer Patient;Cause of Death;CD4 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell mediated immune response;Cells;Cessation of life;Chromatin;chronic infection;Complex;Computer Analysis;CRISPR/Cas technology;cytokine;Data;Deacetylase;Development;dimer;DNA-Binding Proteins;Experimental Neoplasms;Gene Expression;Gene Expression Profiling;gene regulatory network;Generations;genetic analysis;Genetic Transcription;genome editing;high throughput analysis;HIV;Immune response;Immune system;immunodeficiency;Immunology;in vivo;Infection;interest;Interleukin-13;Interleukin-4;Interleukin-5;intraepithelial;Laboratories;laboratory experiment;Leukocytes;Life;Ligands;Lymphocyte;Major Histocompatibility Complex;Maps;Mature T-Lymphocyte;Membrane Glycoproteins;Modeling;Molecular;Morbidity - disease rate;mortality;Mutant Strains Mice;Myeloablative Chemotherapy;novel;Nucleosomes;Paper;Peptides;Process;programs;Property;Protein Analysis;protein function;Puberty;Publications;recurrent infection;Research;response;Shapes;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Surface;T cell differentiation;T cell response;T-Cell Depletion;T-Cell Development;T-Lymphocyte;T-Lymphocyte Subsets;Thymocyte Development;Thymus Gland;transcription factor;Transcriptional Regulation;tumor;Tumor Antigens;Work;Zinc Fingers

PROJECT_TITLE: Genetic Analysis of T-cell Differentiation


PI_NAMEs: GILDERSLEEVE, JEFFREY  (contact)

PROJECT_TERMS: Adhesions;Antibodies;Antigens;Avidity;Basic Science;Binding;Binding Sites;Biological Assay;Biological Process;Bovine Serum Albumin;carbohydrate binding protein;carbohydrate receptor;Carbohydrates;Carrier Proteins;Cells;Complex;Development;Diagnostic;Enzyme-Linked Immunosorbent Assay;Epoxy Compounds;Family;Glycopeptides;Glycoproteins;Glycosaminoglycans;high throughput analysis;Immobilization;improved;Inflammation;inhibitor;instrument;interest;Lectin;Libraries;Ligands;macromolecule;Methods;Microarray Analysis;Microscope;miniaturize;Neoglycoproteins;Neoplasm Metastasis;novel;Play;Polysaccharides;Printing;Protein-Carbohydrate Interaction;Proteins;Reagent;Robotics;Role;Slide;Solid;Technology;tool;Translational Research;Tumor Antigens;Vaccines;Viral;Virus

PROJECT_TITLE: Development of a Carbohydrate Microarray


NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PI_NAMEs: DOROSHOW, JAMES  (contact)

PROJECT_TERMS: analog;cancer cell;cell growth;Cell Proliferation;Colon Carcinoma;Cryoelectron Microscopy;cytokine;Dexamethasone;DNA Damage;Down-Regulation;Genes;Goals;Growth;Human;Inflammatory;interest;knock-down;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;Membrane;Molecular Structure;NADPH Oxidase;NADPH Oxidase 1;neoplastic cell;novel;novel therapeutic intervention;Oxidases;Oxidative Stress;pancreatic cancer cells;Production;Protein Isoforms;Regulation;Role;Series;Signal Transduction;Signal Transduction Pathway;Specificity;targeted cancer therapy;Work;Xenograft procedure

PROJECT_TITLE: NADPH Oxidases as Novel Targets for Cancer Therapy


PI_NAMEs: LEE, KYUNG  (contact)

PROJECT_TERMS: Abnormal Cell;Accounting;anti-cancer therapeutic;Binding;Biological Assay;cancer addiction;cancer cell;cancer therapy;Catalytic Domain;Cause of Death;Cell Cycle;Cell division;cell killing;Cell Proliferation;Centrosome;Cessation of life;Collaborations;cross reactivity;Development;Dissociation;drug discovery;Event;expectation;Generations;Goals;histone H1 kinase;Human;inhibitor;Kinetochores;Laboratories;Ligands;Malignant Neoplasms;Mediating;Mission;Mitosis;Mitotic;Molecular;National Center for Advancing Translational Sciences;Nature;Normal Cell;overexpression;Play;PLK1 gene;Polo-Box Domain;Process;Prodrugs;Protein Kinase;protein protein interaction;Reporting;Role;screening;Secure;Series;small molecule;Specificity;Therapeutic Agents;tumorigenesis;Water

PROJECT_TITLE: Development of inhibitors targeting Plk1 polo-box domain


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Kidney Disease;Neurofibromatosis;Neurosciences;Orphan Drug;Prostate Cancer;Rare Diseases;Urologic Diseases

PI_NAMEs: NECKERS, LEONARD  (contact)

PROJECT_TERMS: addiction;androgen independent prostate cancer;Biochemical;Biological Assay;cancer cell;cancer type;Cell Cycle Arrest;Cell Line;Cell Proliferation;Cell Survival;Cells;chimeric antigen receptor T cells;Complex;Cytosol;Dasatinib;Data;Data Analyses;design;Development;Down-Regulation;Drug Targeting;Ewings sarcoma;Exhibits;Fumarate Hydratase;Genetic Transcription;Glycolysis;Glycolysis Inhibition;Growth;Hereditary Leiomyomatosis and Renal Cell Cancer;high throughput screening;Histologic;In Vitro;in vivo;Inherited;inhibitor;Intervention;Kidney Neoplasms;knock-down;Knowledge;Lactate Dehydrogenase;Lead;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;member;Metabolic;metabolic abnormality assessment;Mitochondria;Modeling;Molecular;Mus;neoplastic cell;Neuroendocrine Prostate Cancer;Neurofibromin 2;novel;novel therapeutic intervention;Papillary;Pathway interactions;Patients;Production;Proteins;Pyrazoles;Pyruvate;Renal Carcinoma;Renal Cell Carcinoma;residence;response;Role;Signal Pathway;Small Interfering RNA;Specimen;src-Family Kinases;Structure;Testing;Therapeutic;Time;treatment strategy;tumor;tumor growth;tumor metabolism;Tumor Suppressor Genes;tumor xenograft;Urogenital Cancer;Xenograft Model

PROJECT_TITLE: Role of fumarate hydratase loss in development of HLRCC hereditary kidney cancer


NIH_SPENDING_CATS: Cancer;Genetics;Kidney Disease;Orphan Drug;Rare Diseases

PI_NAMEs: MERINO, MARIA  (contact)

PROJECT_TERMS: Cancer Family;Characteristics;Clinical;Defect;Development;Diagnosis;Disease;Disease Progression;Family;Genes;Genetic;Goals;Histologic;Inherited;insight;Kidney;Knowledge;Learning;Morphology;Mutation;novel marker;novel therapeutics;Pathway interactions;Patients;Renal Carcinoma;Renal Cell Carcinoma;Syndrome;treatment response;tumor

PROJECT_TITLE: Study of Hereditary Renal and Other Familial Syndromes


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PROJECT_TERMS: Alleles;angiogenesis;Binding;blood vessel development;Cancer cell line;CD276 gene;Cell surface;conditional knockout;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Endothelial Cells;Gene Expression Profiling;gene product;Genes;Genetically Engineered Mouse;Growth;Human;interest;Knock-in Mouse;Knockout Mice;Laboratories;Libraries;Ligands;LoxP-flanked allele;Modeling;Mus;Neoplasms in Vascular Tissue;neoplastic cell;Orphan;Physiological;Role;Therapeutic;therapeutic target;tumor;Tumor Cell Line;tumor growth

PROJECT_TITLE: Unraveling the function of CD276


NIH_SPENDING_CATS: Biotechnology;Cancer

PROJECT_TERMS: Agonist;antagonist;Antibodies;Antibody Specificity;B-Lymphocytes;Basic Science;Binding;cancer cell;carbohydrate binding protein;carbohydrate receptor;Carbohydrates;Child;Clinical;Databases;design;Diagnostic;Directed Molecular Evolution;Disease;Disease Progression;Engineering;Evaluation;FDA approved;Goals;high throughput technology;interest;Lectin;Libraries;Malignant Neoplasms;Microarray Analysis;Monoclonal Antibodies;Neuroblastoma;Polysaccharides;Protein-Carbohydrate Interaction;Proteins;Publishing;Reagent;Research;Therapeutic Agents;tool;tumor;tumor progression

PROJECT_TITLE: Carbohydrate Microarray Profiling of Glycan-Binding Antibodies and Lectins


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: MELTZER, PAUL S. (contact)

PROJECT_TERMS: Adult;Alveolar Rhabdomyosarcoma;Aneuploidy;Behavior;Binding;Binding Proteins;Binding Sites;Biochemical;Biological;Biological Process;Biology;bone;Bone Surface (Peripheral) Osteosarcoma;cancer genome;Candidate Disease Gene;Cell Cycle;Cell Line;Cells;Characteristics;Child;Childhood;childhood sarcoma;Chimeric Proteins;Chromatin;chromatin immunoprecipitation;Chromosomal translocation;Chromosomes;Clinical;Collagen;Collagen Type I;Complex;Complex Mixtures;Connective Tissue;Data;DAXX gene;Defect;Dependence;Development;Diagnosis;Disease;DNA Sequence Alteration;DNA sequencing;druggable target;Event;Ewings sarcoma;EWS-FLI1 fusion protein;Extracellular Matrix;FOXO1A gene;functional genomics;fusion gene;Gene Expression;Genes;Genome;Genomic Instability;genomic profiles;Genomics;Goals;Histologic;Image;interest;Investigation;Laboratories;Malignant - descriptor;Malignant Neoplasms;Malignant Osteoblast;Membrane;Modeling;Molecular;monolayer;multiple omics;Mutation;Nature;Nuclear Structure;Oncogenic;Osteoid;Osteosarcoma;Pathway interactions;PAX3 gene;Phenotype;posttranscriptional;precision medicine;Process;Production;Property;Proteins;Publishing;Reporting;RNA Interference;Role;Sarcoma;spheroids;Stromal Cells;Techniques;Technology;telomere;Telomere Pathway;The Cancer Genome Atlas;transcription factor;tumor;Tumor Biology;Xenograft procedure

PROJECT_TITLE: Functional Genomics of Sarcoma


NIH_SPENDING_CATS: Cancer;HIV/AIDS;Infectious Diseases

PI_NAMEs: FREED, ERIC  (contact)

PROJECT_TERMS: Adverse effects;analog;Anti-Retroviral Agents;Anti-viral Agents;antiretroviral therapy;Betulinic Acid;Binding;Biochemical;Capsid;Cells;Clinical Trials;Collaborations;Conduct Clinical Trials;Development;forging;gag Gene Products;Generations;Genetic Polymorphism;Goals;HIV-1;inhibitor;insight;Link;Maps;Molecular;multidisciplinary;mutant;Mutation;novel;Pathway interactions;Patients;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;Phytic Acid;Play;Polyproteins;Preclinical Testing;Property;Protein Biosynthesis;Research;Resistance;resistance mutation;Resolution;response;Role;Site;SP1 gene;Structural Biologist;structural biology;Structure;Structure-Activity Relationship;Techniques;Time;Toxic effect;Viral;Viral Load result;viral resistance;Virus;Work

PROJECT_TITLE: HIV-1 Maturation


NIH_SPENDING_CATS: Aging;Cancer;Hematology;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: TOSATO, GIOVANNA  (contact)

PROJECT_TERMS: Adult;Affinity;age related changes;aged;Aging;Anemia;Architecture;Area;Blood Cells;bone cell;Bone Marrow;cancer therapy;Cardiovascular Diseases;Cell Physiology;Cells;Cellular Structures;Circulation;Complex;CXCR4 gene;Development;Disease;Effectiveness;Endothelial Cells;Endothelium;experimental study;Goals;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Heterogeneity;immune cell checkpoints;immune checkpoint;Immunologics;Impairment;inhibitor;Location;Lymphopoiesis;Malignant Neoplasms;mortality;Movement;Mus;Myeloid Cells;Myelopoiesis;Nature;old mice;Peripheral;Phenotype;Population;progenitor;programmed cell death protein 1;Proteins;PTPN11 gene;reconstitution;Research;Research Project Grants;Risk;Role;Signal Transduction;stem;stem cells;Stromal Cell-Derived Factor 1;T-Lymphocyte;Testing;Therapeutic;tumor progression

PROJECT_TITLE: Study of the Roles of SDF1 and CXCR4 in Hematopoiesis


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Coronaviruses;Digestive Diseases;Immunotherapy;Infectious Diseases;Inflammatory Bowel Disease;Liver Cancer;Liver Disease;Rare Diseases

PI_NAMEs: LIU, ZHENG-GANG  (contact)

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Acute;adaptive immune response;Affect;angiogenesis;Animal Cancer Model;antagonist;Anti-Tumor Necrosis Factor Therapy;Antigen-Antibody Complex;Antigens;Antineoplastic Agents;Apoptotic;arginase;Arthritis;Autoimmune;Autoimmune Diseases;Biological;Blood Vessels;cancer therapy;cancer type;Cell Proliferation;Chronic;chronic inflammatory disease;Collaborations;colon carcinogenesis;COVID-19;Crohn's disease;cytokine release syndrome;cytotoxicity;Development;Disease;Dose;Emigrations;Exhibits;extracellular;Genes;Glucocorticoids;Growth;Helicobacter Infections;Hepatitis C;Immature Monocyte;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Innate Immune Response;Innate Immune System;Interferons;Interleukin-1;Interleukin-10;Interleukin-13;Interleukin-4;Invaded;Knock-out;Laboratories;leukemia/lymphoma;Lipopolysaccharides;Lymphangiogenesis;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Mediator;Modeling;Molecular;monocyte;mouse model;Multiple Sclerosis;Mus;Necrosis;Neoplasm Metastasis;neoplastic cell;neutralizing antibody;NF-kappa B;Nitric Oxide;Parasites;Participant;pathogen;Pathogenesis;Pathologic;Pathology;Pathway interactions;Peripheral;Phenotype;Play;Primary carcinoma of the liver cells;Process;Production;Proteins;Regulation;Research;response;Rheumatoid Arthritis;Role;SARS-CoV-2 infection;Septic Shock;Signal Pathway;Site;T-Lymphocyte;Testing;Therapeutic;Thrombosis;Tissue Differentiation;Tissues;TNF gene;TNFR1 Signaling Pathway;transcription factor;Transforming Growth Factors;tumor;tumor growth;tumor initiation;Tumor Promotion;Tumor-associated macrophages;tumorigenesis;Virus Diseases;Whole Organism

PROJECT_TITLE: Inflammation, Macrophage Differentiation, and Cancer


NIH_SPENDING_CATS: Cancer;Genetics;Human Fetal Tissue;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: THIELE, CAROL J (contact)

PROJECT_TERMS: Affect;Automobile Driving;Binding;Binding Proteins;Biological Assay;Biological Models;Bypass;cdc Genes;Cell Cycle Progression;Cell Differentiation process;cell growth;Cell Lineage;Cell Survival;cell type;Characteristics;Child;Classification;Clinical;Clinical Course of Disease;Cues;Development;Differentiated Gene;Differentiation and Growth;DNA;Drosophila genus;effective therapy;Enhancers;Epigenetic Process;experimental study;gangliocytoma;Ganglioneuroblastoma;Gene Expression;Gene set enrichment analysis;Genes;Genetic Transcription;genome-wide;Genomics;Goals;Growth;Histologic;Homologous Gene;Human;Immunoprecipitation;Impairment;improved;indexing;loss of function;Mediating;Mitotic;Molecular;Mutation;MYCN gene;Nature;neoplastic cell;Nerve Growth Factor Receptors;nerve stem cell;neural;Neural Crest;Neural Crest Cell;Neuroblastoma;neuroblastoma cell;Neuroepithelial, Perineurial, and Schwann Cell Neoplasm;Neurotrophic Tyrosine Kinase Receptor Type 2;NFIX gene;novel;Oncogenic;Pathologic;Pattern;pediatric embryonal tumor;PPARG gene;Process;progenitor;Prognosis;programs;promoter;Property;Publishing;RARB gene;Regulation;Research;Retinoic Acid Receptor;Retinoids;Role;self-renewal;Signal Transduction Pathway;SOX11 gene;SOX4 gene;Specimen;Stem Cell Development;stem cells;Supporting Cell;survival outcome;Testing;Time;Tissues;transcription factor;Transcriptional Regulation;Tretinoin;tumor;tumorigenesis;Tumorigenicity;Xenograft procedure

PROJECT_TITLE: Regulation of Differentiation of Pediatric Embryonal Tumors- Neuroblastoma


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;HIV/AIDS;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Immunotherapy;Infectious Diseases;Racial and Ethnic Minority Health Research;Vaccine Related

PI_NAMEs: CARRINGTON, MARY N. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Affinity;Africa;Alleles;Antigen Presentation;antigen test;Antigens;Asian;Autoimmune Diseases;Binding;Biological;Biological Assay;Biological Process;Black Populations;Black race;cancer immunotherapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD94 Antigen;Cell surface;Cells;Characteristics;cohort;Cohort Analysis;Communicable Diseases;Complex;Data;Data Set;Databases;Dependence;Development;Disease;Disease Outcome;env Gene Products;Enzyme-Linked Immunosorbent Assay;Freedom;gag Gene Products;Genes;Genetic;genetic association;Genetic Polymorphism;Genotype;Goals;HIV;HIV Antigens;HIV Infections;HIV-1;HLA-B Antigens;human disease;human leukocyte antigen testing;Immune;Immune response;Immune Response Genes;Immunogenetics;immunogenicity;Immunoglobulins;Immunologic Receptors;improved;Individual;Innate Immune Response;interest;Interruption;Killer Cells;KLRD1 gene;Knowledge;Leukocytes;Ligands;Loss of Heterozygosity;Malignant Neoplasms;Measures;Messenger RNA;Molecular;mosaic;Natural History;Natural Killer Cells;neoantigens;novel;Outcome;Participant;Peptide Signal Sequences;Peptides;Phase;Predisposition;Principal Component Analysis;Process;Property;Proteins;receptor;Regimen;Resistance;Resources;response;Risk;Signal Pathway;South Africa;Stains;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Thailand;Time;tool;Transplantation;Vaccination;Vaccine Design;vaccine evaluation;vaccine response;vaccine trial;Vaccinee;Variant;vector;Viral Load result;Virus

PROJECT_TITLE: Effects of genetic polymorphism in MHC, KIR, and related loci on human disease


PROJECT_TERMS: adaptive immune response;Affect;Affinity;Alleles;Amino Acid Substitution;Binding;Blood donor;C-terminal;CD3 Antigens;CD94 Antigen;Cell Line;Cell surface;Cells;cohort;Complex;CRISPR/Cas technology;Data;Dependence;Development;differential expression;Disease;disorder risk;Down-Regulation;Effector Cell;Endoplasmic Reticulum;Epitopes;experimental study;Flow Cytometry;GEM gene;Genes;Genetic Polymorphism;Genetic study;Genotype;HLA-A gene;HLA-B Antigens;HLA-B57;HLA-C Antigens;human disease;Hydrophobicity;Immunogenetics;In Vitro;Innate Immune Response;insight;interest;Investigation;K562 Cells;KLRD1 gene;Knock-out;lentivirally transduced;Mass Spectrum Analysis;Measures;Messenger RNA;Molecular Genetics;Natural Killer Cells;novel;Peptide Fragments;Peptide Signal Sequences;Peptides;Population Study;preference;Property;Proteins;Publications;receptor;Regulation;Resolution;Role;signal peptide peptidase;Signal Recognition Particle;single-cell RNA sequencing;Surface;T-Lymphocyte;Transcript;Translations;Variant

PROJECT_TITLE: Molecular genetics and population studies of the KIR and HLA gene complexes


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Liver Disease;Lung;Lung Cancer;Microbiome;Prevention;Skin Cancer

PI_NAMEs: TRINCHIERI, GIORGIO  (contact)

PROJECT_TERMS: Acceleration;acquired immunity;adaptive immunity;Adenocarcinoma;adenoma;Affect;Animal Model;Animals;anti-PD-1;anti-PD1 therapy;Antitumor Response;Attenuated;Automobile Driving;Azoxymethane;Beta-glucuronidase;Biological Assay;Cancer Biology;cancer cell;cancer therapy;carcinogenesis;CD4 Positive T Lymphocytes;Cell Physiology;Cell Proliferation;cell type;Cells;checkpoint therapy;Chemical Models;Chronic;Colitis associated colorectal cancer;Colon;colon carcinogenesis;Communicable Diseases;CSF1R gene;cytokine;Cytokine Signaling;cytotoxic CD8 T cells;Data;Dendritic Cells;Development;dextran sulfate sodium induced colitis;Dichloromethylene Diphosphonate;Disease;Effector Cell;Environment;Equilibrium;exhaustion;Exposure to;Family;fecal transplantation;fibrosarcoma;Fostering;Frequencies;Gene Expression;gene product;Genetic;Genetic Models;Growth;gut microbiome;gut microbiota;healing;Hepatocarcinogenesis;Homeostasis;Human;IL17 gene;IL18 gene;Immune;Immune response;Immunity;improved;In Vitro;in vivo;Infection;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;inflammatory modulation;Inflammatory Response;inhibitor;Interferon Type I;Interferon Type II;Interleukin-1 Receptors;Interleukin-10;Interleukin-12;interleukin-18 receptor;interleukin-22;interleukin-23;ITGAM gene;Knock-out;KRAS2 gene;Kupffer Cells;Lamina Propria;Light;Liver;LoxP-flanked allele;Lung;Lung Adenocarcinoma;Macrophage;Macrophage Activation;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Melanoma;member;Microbe;microbial;microbial products;microbiome;migration;Modeling;Molecular;monocyte;Morphogenesis;morphogens;mouse model;Mus;mutant;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Natural Killer Cells;Natural Resistance;Neoplasm Metastasis;neutrophil;novel;Oncogenic;oral microbiome;Organism;Paralysed;Patients;pharmacologic;Phenotype;Physiological;Play;pleiotropism;Polyps;Population;Population Sizes;prevent;Preventive;Process;Production;programmed cell death protein 1;programs;Prophylactic treatment;receptor;reconstitution;Regulation;Resistance;Resistance to infection;response;restraint;Role;Signal Pathway;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Skin Carcinogenesis;small molecule;Solid Neoplasm;Source;Spleen;STAT3 gene;T-Lymphocyte;Therapeutic;Time;Tissues;TNF gene;Toll-like receptors;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;tumor xenograft;tumor-immune system interactions;tumorigenesis;tumorigenic;Ulcer;Vaccines;Vancomycin;Wild Type Mouse;Work

PROJECT_TITLE: Role of inflammation, innate resistance, and immunity in carcinogenesis


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Human Genome;Women's Health Research

PI_NAMEs: KASHLEV, MIKHAIL  (contact)

PROJECT_TERMS: Alternative Splicing;attenuation;Bacillus subtilis;Bacteria;Biochemical;Bioinformatics;Biological;Biological Assay;Breast Cancer Cell;Breast Cancer cell line;breast cancer progression;cancer cell;cancer recurrence;cancer type;Cells;cleavage factor;Clinical;Code;Codon Nucleotides;Complex;Coupled;Coupling;Disease;Distal;DNA;DNA lesion;DNA Repair;Energy-Generating Resources;Environment;Epigenetic Process;ERBB2 gene;Escherichia coli;Estrogen receptor negative;Eukaryota;Eukaryotic Cell;Event;Exhibits;Failure;Frequencies;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic approach;Genetic Transcription;genome-wide;Genomic Instability;Growth;hormone therapy;Human;Hypoxia;In Vitro;in vivo;Investigation;Laboratories;Malignant Breast Neoplasm;Malignant Neoplasms;Metabolic;Methodology;Methods;Modeling;Molecular;Nature;Neoplasm Metastasis;Nonsense Mutation;Nucleosomes;Outcome;Oxidative Phosphorylation;Pathway interactions;Pattern;Phosphorylation;Play;Polymerase;Positioning Attribute;Productivity;Progesterone Receptors;Prognosis;Prokaryotic Cells;Proliferating;promoter;Proteins;recruit;Regulation;Reporter Genes;Resolution;RNA;RNA Polymerase II;RNA Processing;Role;Signal Transduction;Site;Solid Neoplasm;Specificity;Structure;Technology;termination factor;Testing;Time;Transcript;Transcription Elongation;transcription factor S-II;Transcription Initiation Site;Transcription Process;transcription termination;Transcriptional Regulation;transcriptome sequencing;Translations;triple-negative invasive breast carcinoma;tumor;tumor progression;tumorigenesis;Woman;Yeasts

PROJECT_TITLE: Mechanisms of transcription pausing and fidelity in prokaryotes and eukaryotes


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Human Genome;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: KHAN, JAVED  (contact)

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Immunotherapy;ALK gene;Animal Model;Antigen Targeting;Antigens;Apoptosis;Automobile Driving;Biological Assay;Biological Products;Blood;Brain Neoplasms;CAR T cell therapy;CD276 gene;Cell Death;cell growth;cell killing;Cell Line;Cell Therapy;Cells;Childhood Solid Neoplasm;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Complex;CRISPR screen;CRISPR/Cas technology;cytotoxicity;density;Detection;Developing Countries;Development;Diagnostic;diagnostic biomarker;Diagnostic Imaging;differential expression;Dominant-Negative Mutation;Down-Regulation;Drug Compounding;Drug Screening;Drug usage;Effectiveness;Enhancers;Epigenetic Process;Evaluation;exhaust;exhaustion;FDA approved;FGFR4 gene;FOXO1A gene;fusion gene;Future;gene repression;Generations;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Goals;Growth;hazard;high risk;high throughput screening;Human;Immune Targeting;Immunotherapeutic agent;Immunotherapy;In Vitro;in vivo;inhibitor;Investigation;Knock-in;knockout gene;Libraries;Luciferases;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Memory;Methods;Modeling;Monitor;Monoclonal Antibodies;multimodality;Mus;muscle regeneration;Mutate;Mutation;Myoblasts;National Center for Advancing Translational Sciences;neoplastic cell;Neural Cell Adhesion Molecule L1;Neuroblastoma;Normal tissue morphology;novel;novel strategies;novel therapeutics;Organ;Osteosarcoma;overexpression;Pathway interactions;patient derived xenograft model;Patients;PAX3 gene;Penetration;Peptides;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Play;Post-Translational Protein Processing;Pre-Clinical Model;preclinical study;preferentially expressed antigen in melanoma;Prognostic Marker;programs;Property;protein protein interaction;Proteins;Reporter;response;Rhabdomyosarcoma;Role;Signal Transduction;Small Interfering RNA;small molecule;Solid Neoplasm;synergism;System;T-Lymphocyte;targeted treatment;Testing;TGFBR2 gene;Therapeutic;therapeutic target;Toxic effect;TP53 gene;Translating;treatment response;tumor;Tumor Antigens;tumor-immune system interactions;Xenograft procedure

PROJECT_TITLE: Developing Novel Therapies for High Risk Pediatric Cancers


PI_NAMEs: BAI, YAWEN  (contact)

PROJECT_TERMS: Binding;Chromatin;Chromatin Structure;Cryoelectron Microscopy;DNA;DNA Sequence;Eukaryota;GATA4 gene;gene function;Genome;High Mobility Group Proteins;Histones;insight;interest;Kinetochores;Linker DNA;Mediating;Molecular Chaperones;Nucleosomes;Play;Positioning Attribute;Proteins;Role;Structure;transcription factor

PROJECT_TITLE: Chromatin structure and dynamics


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;HIV/AIDS;Human Genome;Infectious Diseases

PI_NAMEs: HU, WEI-SHAU  (contact)

PROJECT_TERMS: 5' Untranslated Regions;Adopted;Affect;Binding;Biochemical;Biological Assay;Complex;Cytoplasm;Defect;design;Dimerization;Elements;Epidemic;Evolution;Exhibits;exportin 1 protein;fitness;Genetic Transcription;Genome;Goals;Guanosine;HIV;HIV-1;Image;improved;insight;Integration Host Factors;Knowledge;Length;Light;Methods;Molecular Conformation;mutant;novel;Nucleotides;pathogen;Pathway interactions;pol Gene Products;Polyribosomes;polysome profiling;Primate Lentiviruses;Proteins;Proviruses;Regulation;rev Protein;rev-Responsive Elements;Ribosomes;RNA;RNA Folding;RNA Transport;Role;Site;Structure;Transcript;Transcription Initiation;Transcription Initiation Site;Translating;Translations;Treatment Protocols;Vaccines;Viral;Viral Genome;Viral Proteins;Virion;Virus;Virus Latency;Virus Replication

PROJECT_TITLE: Elucidating the Regulation of HIV RNA Functions:Translation and Genome Packaging


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Ovarian Cancer;Pancreatic Cancer;Prevention;Rare Diseases;Women's Health Research

PI_NAMEs: HASSAN, RAFFIT  (contact)

PROJECT_TERMS: Adoptive Cell Transfers;Affinity;Animal Model;Antibodies;antitumor effect;BRCA1 gene;Breast Cancer Early Detection;C-terminal;cancer type;CAR T cell therapy;CCR;Cell Line;Cell surface;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;CLIA certified;Clinic;Clinical;clinical development;Clinical Trials;cohort;Complex;Cutaneous Melanoma;cytotoxicity test;Diagnosis;differential expression;Differentiation Antigens;disease-causing mutation;Distal;DNA Repair;DNA Repair Gene;Early Diagnosis;effective therapy;efficacy study;Eligibility Determination;Enrollment;Epitopes;exhaustion;Family;Family member;gene panel;Gene Proteins;genetic testing;Germ Lines;Germ-Line Mutation;Goals;Human;Immunocompetent;Immunocompromised Host;Immunosuppression;improved;Incidence;Individual;Large Intestine Carcinoma;Longterm Follow-up;Malignant mesothelioma;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of urinary bladder;Malignant Neoplasms;manufacture;Mediating;Membrane;Memory;meningioma;Mesothelial Cell;mesothelin;Mesothelioma;Modeling;Monoclonal Antibodies;Mus;Mutation;neoplastic cell;novel therapeutics;Oryctolagus cuniculus;Outcome;overexpression;Pancreatic Adenocarcinoma;Participant;Pathogenicity;patient derived xenograft model;Patients;PD-1/PD-L1;pericardial sac;Peritoneum;Phase;phase 1 study;Phase I Clinical Trials;phase I trial;phase II trial;Pleura;pre-clinical;Pre-Clinical Model;preclinical study;Predisposition;programmed cell death ligand 1;programs;prospective;Proteins;Protocols documentation;receptor;Recording of previous events;Regulation;Renal Carcinoma;Research;Risk;Role;Safety;screening;Screening for cancer;Signal Transduction;Solid Neoplasm;stem cells;Stomach Carcinoma;Surface;Susceptibility Gene;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;therapy development;Toxic effect;Translating;tumor;Tumor Antigens;tumor microenvironment;United States National Institutes of Health;Uveal Melanoma;Variant;Work

PROJECT_TITLE: Adoptive cell therapy for malignant mesothelioma and other mesothelin expressing


NIH_SPENDING_CATS: Antimicrobial Resistance;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;HIV/AIDS;Infectious Diseases;Prevention

PI_NAMEs: MALDARELLI, FRANK  (contact)

PROJECT_TERMS: Acute;Adult;Africa South of the Sahara;algorithm development;Algorithms;Anti-Retroviral Agents;antiretroviral therapy;assay development;Binding;Bioinformatics;Blood Cells;cathinone;Cells;Chronic;Clinical;Collaborations;Country;Data;Development;Diagnosis;DNA Sequence;driving force;Drug resistance;drug resistance development;drug testing;Early identification;Epidemic;Equilibrium;Genetic;genetic analysis;Genetic Polymorphism;Genetic Population Study;Genetic Recombination;Genetic Transcription;Genetic Variation;Genome;Genotype;Goals;High Prevalence;HIV;HIV drug resistance;HIV Infections;HIV risk;HIV-1;in vivo;Incidence;Individual;Indonesia;Infection;inhibitor;insight;intravenous drug user;invention;Israel;laboratory accident;Length;Link;men;Methods;Molds;Molecular Evolution;Mutation;Nature;Newly Diagnosed;next generation;novel strategies;Patients;Pattern;Peripheral Blood Mononuclear Cell;Plasma;Population;population based;Population Dynamics;Population Heterogeneity;Population Sizes;Positioning Attribute;Prevention approach;Protocols documentation;Proviruses;Public Health;Publications;Reporting;Research;Research Personnel;Resistance;Resistance development;resistance mutation;Risk;Risk Factors;RNA;Sampling;Shapes;Structure;technique development;Technology;United States National Institutes of Health;Universities;Unsafe Sex;Variant;Vertical Transmission;Viral;Viremia;Washington

PROJECT_TITLE: HIV-1 Genetic Variation in Infected Individuals


PI_NAMEs: BASRAI, MUNIRA  (contact)

PROJECT_TERMS: Acetylation;Address;Affect;Aneuploidy;anti-cancer research;Area;Basic Science;Biochemical;Biological Assay;cancer cell;cancer therapy;Cell Cycle;Cell Cycle Regulation;Cell Line;Cell model;Cells;Cellular biology;Centromere;centromere protein A;Chromatin;Chromosomal Instability;Chromosomal Stability;chromosome loss;chromosome missegregation;Chromosome Segregation;Chromosomes;Clinic;Clinical Trials;cohesin;cohesion;constitutive expression;daughter cell;DAXX gene;Defect;Diagnosis;Diploidy;DNA;DNA Sequence;dosage;Dose;Drosophila polo protein;established cell line;Euchromatin;Excision;F-Box Proteins;fly;Follow-Up Studies;Future;Gene Dosage;Genes;Genetic;Genome;genome wide screen;genome-wide;Hela Cells;Heterogeneity;Histone Acetylation;Histone Deacetylase Inhibitor;Histone H3;Histone H4;Histones;Homologous Gene;Human;human model;Image;In Vitro;in vivo;Incidence;inducible gene expression;insight;interdisciplinary approach;Kinetochores;Link;Lysine;Malignant Neoplasms;Mediating;Methylation;micronucleus;Microtubules;Mitotic;Molecular;Molecular Chaperones;Molecular Conformation;mouse model;multidisciplinary;Mus;Nuclear;Nucleosomes;overexpression;Pathway interactions;Phenotype;Phosphorylation;Phosphotransferases;Post Translational Modification Analysis;Post-Translational Protein Processing;prevent;Process;Prognosis;Proliferating;Proteins;Proteolysis;Regulation;Research;RNA interference screen;Role;Saccharomyces cerevisiae;Saccharomycetales;Site;Solid Neoplasm;stoichiometry;Sumoylation Pathway;targeted treatment;tool;Topoisomerase II;Translating;transmission process;tumorigenesis;Ubiquitin-mediated Proteolysis Pathway;Ubiquitination;Variant;Xenograft procedure;Yeast Model System;Yeasts

PROJECT_TITLE: Molecular Determinants of Chromosome Transmission and Cell Cycle Regulation


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Ovarian Cancer;Pancreatic Cancer;Rare Diseases;Women's Health Research

PI_NAMEs: GOTTESMAN, MICHAEL  (contact)

PROJECT_TERMS: 3-Dimensional;ABCB1 gene;ABCC1 gene;ABCG2 gene;Affect;Amino Acid Transporter;Animal Model;anti-microbial drug;Antineoplastic Agents;ATAC-seq;Attenuated;Binding;Bioreactors;Blood capillaries;Breast Cancer Cell;cancer cell;Cancer Cell Growth;Cancer cell line;cancer drug resistance;Cataloging;Cell Death;Cell Line;Cell Physiology;Cell Survival;Cells;CHEK1 gene;chemotherapy;Chickens;Cisplatin;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Colon Carcinoma;Complex;CRISPR screen;Cultured Cells;Cutaneous;Cytotoxic agent;Development;Diffusion;Disease;Drug resistance;drug resistance development;efflux pump;Exposure to;FDA approved;Fishes;Future;Gene Expression;Gene Expression Profile;Genes;Genomics;Goals;Growth;Guide RNA;HDAC3 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;Homologous Gene;Hydrogels;In Vitro;in vivo;inhibitor;knock-down;Knock-out;Length;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;MCF7 cell;Methylation;Methyltransferase;Microtubule Stabilization;Microtubules;Modeling;Molecular;Multi-Drug Resistance;Multidrug Resistance-Associated Proteins;Mus;neurotoxicity;novel;overexpression;oxaliplatin;Oxygen;Paclitaxel;pancreatic cancer cells;paralogous gene;Pathway interactions;Patients;Pattern;Peripheral;Pharmaceutical Preparations;Phenotype;Physiological;Platinum Compounds;Play;polymerization;Polymers;Precision Run-On Sequencing;prevent;Probability;Protein Isoforms;Proteins;Rattus;Resistance;resistance mechanism;Role;scale up;Silicon;small molecule inhibitor;Solid Neoplasm;Specificity;Specimen;Sulfhydryl Compounds;Suspensions;System;T-Cell Lymphoma;Technology;Testing;Toxic effect;transcriptome sequencing;Transfection;Transgenic Organisms;Tubulin;tumor;uptake;Validation;Verapamil;Vertebrates;Vorinostat;Zebrafish;Zinc

PROJECT_TITLE: Mechanisms of non-classical multidrug resistance in cancer


NIH_SPENDING_CATS: Cancer

PI_NAMEs: NICKLAUS, MARC  (contact)

PROJECT_TERMS: Active Sites;aqueous;Binding;Binding Proteins;Binding Sites;Chemicals;Complex;Computer Analysis;Computer software;Data;Data Set;Databases;Docking;drug action;Drug Design;Environment;Enzymes;flexibility;Future;Goals;Libraries;Ligands;Linux;Methodology;Modeling;Molecular Conformation;Pharmaceutical Preparations;Process;protein complex;protein data bank;Proteins;Publications;quantum;quantum computing;Quantum Mechanics;Resources;Running;screening;small molecule;Solvents;Structure;theories;Time;United States National Institutes of Health;Vacuum;Visit;Work;X-Ray Crystallography

PROJECT_TITLE: Fundamentals of Ligand-Protein Interactions


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Rare Diseases;Women's Health Research

PI_NAMEs: ZHURKIN, VICTOR  (contact)

PROJECT_TERMS: Address;Agreement;Biological Assay;Breast Cancer Cell;Breast Cancer Patient;Cancer Diagnostics;cancer type;cell free DNA;Cell Nucleus;Cell Physiology;Cells;cellular imaging;Chromatin;Chromatin Fiber;Chromatin Structure;Chromophobe Renal Cell Carcinoma;Clear Cell;Clinic;Clinical;cohort;Collaborations;Coupled;Data;density;Diagnostic;Disease;DNA;DNA Binding;DNA Folding;DNA Methylation;DNA Sequence;DNA-Directed RNA Polymerase;Electron Microscope;Epigenetic Process;Equilibrium;Family;Fiber;Foundations;Future;Gel;Gene Expression Regulation;Genes;Genetic Polymorphism;Genetic Transcription;Genome;genome-wide;genome-wide analysis;Genomic DNA;Geometry;Goals;Heterochromatin;Histones;Human;in vivo;Knowledge;Length;Link;Linker DNA;liquid biopsy;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Medical;Methodology;Molecular Conformation;Monitor;neoplastic cell;Normal tissue morphology;novel;Nucleic Acid Regulatory Sequences;Nucleosomal Repeat Length;Nucleosomes;Nucleotides;Organism;Paper;Patients;Phase;Positioning Attribute;Prevalence;Proteins;Publishing;Regulation;Renal Cell Carcinoma;Research Personnel;Resolution;RNA;Roentgen Rays;Side;Solid;stem;Stratification;Structure;Structure-Activity Relationship;Superhelical DNA;Techniques;Time;Tissues;tomography;transcription factor;Transcription Process;tumor;Tumor Tissue;ultra high resolution;Universities;Urologic Oncology;Variant;Yeasts

PROJECT_TITLE: DNA Folding in Chromatin at the Supra-nucleosome Level


NIH_SPENDING_CATS: Cancer;Genetics

PROJECT_TERMS: 3-Dimensional;Acetylation;Affect;Affinity;Agreement;Alu Elements;Anisotropy;Apoptosis;Apoptotic;Binding;Binding Sites;Biological Process;cancer cell;Cell Cycle Arrest;cell type;Cells;Chromatin;Combinatorics;Computer Analysis;Coupled;Data;Deoxyribonuclease I;DNA;DNA Binding;DNA Folding;DNA Methylation;DNA-Protein Interaction;Elements;Environment;Epigenetic Process;epigenetic regulation;Exhibits;Family;flexibility;gene induction;Genes;Genetic Transcription;Genomic DNA;Goals;Heterochromatin;Histone Acetylation;Histone H1;Histone H2A;Histone H4;histone modification;Histones;Human;In Vitro;in vitro Model;in vivo;insight;Intuition;Kinetics;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Molecular Conformation;Normal Cell;novel;Nucleosomes;Pattern;Positioning Attribute;Post-Translational Protein Processing;prevent;Probability;Publishing;reconstitution;Repression;Research;response;Response Elements;Roentgen Rays;Shapes;Signal Transduction;Site;Structure;Surface;Tail;Time;TP53 gene;transcription factor;Transcriptional Regulation;transcriptional reprogramming;Tumor Suppressor Proteins;Work;Xenopus

PROJECT_TITLE: p53-induced Regulation of Transcription in the Chromatin Context


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Physical Injury - Accidents and Adverse Effects;Pulmonary Fibrosis;Radiation Oncology

PI_NAMEs: CITRIN, DEBORAH  (contact)

PROJECT_TERMS: Acceleration;Accidents;Aging;Alveolar;alveolar type II cell;Alveolus;Binding;Biological Markers;Candidate Disease Gene;candidate identification;Cd68;Cell Aging;Cellular Stress;Chest;Chronic;clinical translation;Coculture Techniques;Collaborations;Collagen;Complex;Corn Oil;cytokine;Data;Data Set;Databases;diphenyleneiodonium;Dose;effective therapy;EGF gene;Evaluation;Exhibits;Exons;experience;Exposure to;Family member;Fibroblasts;Fibrosis;fibrotic lung;FRAP1 gene;Gene Expression Profiling;Genes;Goals;Histologic;Human;human tissue;Hydroxyeicosatetraenoic Acids;IGF1 gene;IGF1R gene;immunoregulation;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;inhibitor;Injury;Insulin-Like Growth Factor I;Interleukin-1 alpha;Interleukin-13;Interleukin-6;Intervention;irradiation;ITGAM gene;Knowledge;Laboratories;Laboratory Finding;Late Radiation Injury;Link;LOX gene;Lung;lung injury;Macrophage;Mediating;member;Methods;Micro Array Data;Modeling;mTOR inhibition;mTOR Signaling Pathway;Mus;NADPH Oxidase;neutralizing antibody;Normal tissue morphology;Oncogenes;Operative Surgical Procedures;Organ;Oxidative Stress;Pathway interactions;Patients;phenotypic biomarker;Phosphorylation;Plasminogen Activator Inhibitor 1;Play;pneumocyte;premature;prevent;Production;protein expression;Proteins;Publications;Pulmonary Fibrosis;Radiation;Radiation exposure;Radiation Fibrosis;Radiation Injuries;radiation mitigation;Radiation Protection;Radiation therapy;radiation-induced lung injury;radioresistant;Recombinants;Resected;Resistance;response;Role;senescence;senescence associated secretory phenotype;senescent cell;Signal Induction;Signal Transduction;Sirolimus;Site;skin fibrosis;stem cells;Structure of parenchyma of lung;success;Superoxides;Tamoxifen;Testing;Therapeutic;Therapeutic Intervention;tissue stem cells;Tissues;Toxic effect;Transforming Growth Factor beta;tumor growth;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Mechanisms of Normal Tissue Toxicity From Irradiation


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Immunotherapy;Infectious Diseases;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: HICKSTEIN, DENNIS  (contact)

PROJECT_TERMS: Acute;Adolescence;Allogenic;B-Lymphocytes;Biological;Chimerism;chronic graft versus host disease;Clinical;Clinical Protocols;curative treatments;Disease;Disease-Free Survival;Dysmyelopoietic Syndromes;emerging adult;Engraftment;Flow Cytometry;GATA2 deficiency;Hematology;Hematopoiesis;Hematopoietic Stem Cell Transplantation;immune reconstitution;Immunologic Deficiency Syndromes;Incidence;Individual;Infection;Kinetics;leukemia;Leukocytes;monocyte;Mutation;Mycobacterium avium Complex;Natural Killer Cells;Opportunistic Infections;patient population;Patients;Pattern;peripheral blood;Phenotype;Population;primary endpoint;reconstitution;Recording of previous events;Residual state;Safety;Syndrome;T cell reconstitution;T-Cell Depletion;T-Lymphocyte;Therapeutic;Time;Toxic effect;Transplantation

PROJECT_TITLE: Hematopoietic Stem Cell Transplant for GATA2 Deficiency


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Hepatitis;Human Genome;Infectious Diseases;Liver Cancer;Liver Disease;Precision Medicine;Prevention;Rare Diseases

PI_NAMEs: WANG, XIN WEI  (contact)

PROJECT_TERMS: Address;agricultural pesticide;Agriculture;Architecture;Area;B-Lymphocytes;Behavioral;Biological;Biopsy;carcinogenesis;Caring;CD8-Positive T-Lymphocytes;Cell Communication;cell type;Cells;Chinese;Classification;Clinical;Clonality;cohort;combinatorial;Complex;Country;Data;Death Rate;Detection;Diabetes Mellitus;diagnostic tool;drinking water;early onset;Ecology;Ecosystem;effective therapy;Environmental Exposure;Environmental Risk Factor;Ethnic Origin;Etiology;Evolution;Fasciola hepatica;fitness;Future;Gene Expression;Genes;Genomics;hazard;Heterogeneity;Image;Immune;immune cell infiltrate;Immunofluorescence Immunologic;Incidence;indexing;Infection;Inter-tumoral heterogeneity;International;Intrahepatic Cholangiocarcinoma;Joints;Kenya;Life Style;Linear Models;Link;Liver;liver biopsy;liver cancer patient;Logistic Regressions;longitudinal analysis;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Medical;Medical History;metabolomics;Modality;Modeling;Molecular;Monitor;mortality;multiplexed imaging;Mutation;Neighborhoods;neoplastic cell;Non-linear Models;novel;Outcome;patient prognosis;patient stratification;Patient-Focused Outcomes;Patients;Pattern;pesticide exposure;Phylogeny;Pilot Projects;Population Heterogeneity;Population Study;Predatory Behavior;predict clinical outcome;predictive tools;Prevention;Primary carcinoma of the liver cells;Process;Race;Research;response;Risk;Risk Factors;risk sharing;Role;Sampling;Shapes;Solid;Somatic Mutation;Source;Specimen;Structure;Subgroup;Survivors;survivorship;System;Technology;Thailand;Therapeutic Intervention;Time;TP53 gene;transcriptome;transcriptomics;Treatment Failure;treatment response;Trees;tumor;Tumor Biology;tumor heterogeneity;tumor microenvironment;tumor progression;Variant;Viral hepatitis

PROJECT_TITLE: Molecular heterogeneity of liver cancer and its clinical impacts


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Cancer;Liver Disease;Nutrition;Obesity;Rare Diseases

PROJECT_TERMS: Affect;Alleles;American;Body fat;Body mass index;Body Regions;cohort;Development;Diet;Diethylnitrosamine;Epidemiology;Etiology;European;Exhibits;Family member;Genetic;genetic risk factor;genetic variant;Genetically Engineered Mouse;genome wide association study;Heat shock proteins;Hepatitis B Virus;Hepatitis C virus;Hepatocyte;Heritability;high risk;Human;Incidence;Individual;Inflammatory Response;Inherited;Link;Lipids;Liver Cirrhosis;Liver diseases;Malignant neoplasm of liver;Malignant Neoplasms;member;Metabolic;Metabolic syndrome;metabolic-associated fatty liver disease;Mitochondria;mitochondrial dysfunction;Molecular;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Obesity;Outcome;Patients;Play;Population;prevent;Primary carcinoma of the liver cells;Prognosis;Prospective, cohort study;Protein Family;Quantitative Trait Loci;Research;Risk;risk variant;Role;Steatohepatitis;trait;trend;Twin Studies;Unhealthy Diet;United States;Variant

PROJECT_TITLE: Molecular mechanisms of MASHNASH-related hepatocellular carcinoma


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

PI_NAMEs: WAKEFIELD, LALAGE  (contact)

PROJECT_TERMS: Address;Adult;Advanced Malignant Neoplasm;angiogenesis;antagonist;Biology;Breast Cancer Model;cancer stem cell;cancer therapy;Cell Compartmentation;cell motility;cell type;Cells;Chronic;clinical development;clinical material;Clinical Treatment;Collaborations;Complex;Development;early phase clinical trial;Embryonic Development;Epithelium;Genetic;genetic regulatory protein;Goals;high dimensionality;Homeostasis;Human;imaging modality;Immunologic Surveillance;In Situ;in vivo;insight;Knowledge;Light;Maintenance;Malignant Neoplasms;Mammary Neoplasms;Metastatic breast cancer;Modeling;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Pathway interactions;Patient Selection;Patients;PDL1 inhibitors;pharmacologic;Phenotype;Play;pre-clinical;preclinical study;predictive marker;Prognosis;Proteins;Recovery;Reporter;response;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small cell lung carcinoma;Specific qualifier value;Therapeutic;Therapeutic Agents;Therapeutic Effect;therapeutic target;transcriptomics;Transforming Growth Factor beta;Transforming Growth Factor-Beta Overexpression;Transgenic Organisms;treatment optimization;treatment response;treatment strategy;tumor;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;tumorigenesis;Work

PROJECT_TITLE: Development of TGF-beta antagonists for cancer therapy


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PI_NAMEs: YARCHOAN, ROBERT  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;AIDS related cancer;AIDS therapy;analog;Binding;Biology;Caspase;Cause of Death;CDK4 gene;Cell Line;Cells;Central Nervous System;Clinical Trials;constitutive expression;Cyclin-Dependent Kinases;cytokine;Development;Disease;DNA Viruses;Down-Regulation;effusion;Gene Activation;Genes;Herpesviridae Infections;Highly Active Antiretroviral Therapy;HIV;HIV therapy;Human Herpesvirus 4;Human Herpesvirus 8;Human T-lymphotropic virus 1;Immune;immune function;Immune response;immunoregulation;Infection;Inflammatory;inhibitor;Intercellular adhesion molecule 1;interest;Interleukin-10;Interleukin-6;Kaposi Sarcoma;Laboratory Study;Leptomeninges;Lesion;Lymphoma cell;Lytic;Malignant Neoplasms;Membrane Proteins;Morbidity - disease rate;mortality;Multicentric Angiofollicular Lymphoid Hyperplasia;nano-string;neoplastic cell;novel therapeutics;Oncogenic;Oxidative Stress;Pathogenesis;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Plasmablast;pomalidomide;prevent;primary effusion lymphoma;Proteins;Regulation;Research;response;Role;Serum;single cell sequencing;Stress;Surface;Symptoms;Syndrome;targeted treatment;Technology;Thalidomide;therapy development;tumor;tumorigenesis;Viral;Viral Load result;Virus;virus host interaction;Work

PROJECT_TITLE: Study of Tumor Pathogenesis and Development of Therapies for AIDS Malignancies


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: AMBS, STEFAN  (contact)

PROJECT_TERMS: Affect;African;African American;African American Women;African ancestry;African Women;Age;aggressive breast cancer;American;anti-tumor immune response;Architecture;ATAC-seq;Autopsy;Award;Biological;Biology;biomarker identification;Black race;Blood specimen;Body mass index;Breast;Breast Cancer cell line;Breast Cancer Patient;breast cancer progression;Breast Cancer Risk Factor;breast density;Cancer Biology;cancer health disparity;Cancer Research Project;cancer surgery;Cancerous;CCR;Cell Nucleus;cell type;Cells;Characteristics;Chromatin;Chronic;Chronic Disease;Chronic stress;Clinical;Clinical Research;clinically significant;cohort;Collaborations;comorbidity;Contracts;Cross-Sectional Studies;Crowns;Data;data pipeline;Data Set;deprivation;Development;Diabetes Mellitus;Diagnosis;Digestion;digital;digital pathology;Discrimination;Disease;Disease Outcome;Disparate;Division of Cancer Epidemiology and Genetics;DNA copy number;DNA Methylation;Environment;Environmental Exposure;Epigenetic Process;epigenome;Epithelial Cells;Epithelium;ethnic discrimination;Ethnic Origin;European;European ancestry;Excess Mortality;Exhibits;experience;Fibroblasts;Freezing;Gene Expression;Gene Expression Profile;Genes;Genetic;genome sequencing;genome-wide;health disparity;Heterogeneity;Hormonal;Human;Immune;Immune System Diseases;Immunologics;indexing;Inflammation;inflammatory marker;insight;Inter-tumoral heterogeneity;Investigation;Investments;Kenya;Laboratories;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;Manuscripts;Maryland;Measures;metabolome;Methylation;methylation pattern;Minority Groups;Molecular;molecular subtypes;monocyte;multiple omics;Mutation;Myelogenous;Neighborhoods;neoplastic cell;novel;novel marker;Obesity;Operative Surgical Procedures;Oxidation-Reduction;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;perceived stress;Pericytes;Policies;Population;Population Group;Predisposition;Premenopause;Process;Proteome;Protocols documentation;public health intervention;Publications;Publishing;Race;racial discrimination;Reproductive History;Research;Research Design;Research Personnel;Resolution;Resources;Risk Factors;Role;Schedule;Signal Transduction;single cell analysis;single nucleus RNA-sequencing;Social Environment;Social isolation;Social support;socioeconomic disadvantage;Stress;Stressful Event;stressor;Stromal Cells;Structure;Surveys;survival outcome;System;systemic inflammatory response;T-Lymphocyte;targeted treatment;Technology;Tissue Banks;Tissue Sample;Tissues;transcription factor;transcriptome sequencing;transcriptomic profiling;transcriptomics;triple-negative invasive breast carcinoma;tumor;Tumor Biology;Tumor Markers;Tumor Suppressor Genes;Tumor Tissue;tumor-immune system interactions;Validation;Woman

PROJECT_TITLE: Novel Markers for Disease Outcome in Breast Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Hematology;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS related cancer;AIDS-Related Lymphoma;Antibodies;B-Cell Lymphomas;cancer immunotherapy;CDK4 gene;Central Nervous System Lymphoma;chemotherapy;Clinical Research;Clinical Trials;Collaborations;Conduct Clinical Trials;cytokine;Data;Development;Diagnosis;Disease;Disease Progression;Down-Regulation;feasibility trial;follow-up;Ganciclovir;Herpesviridae;HIV;HIV Infections;HIV Seronegativity;HIV therapy;Human Herpesvirus 8;IL7 gene;Immunotherapy;immunotherapy trials;In Vitro;Infection;Inflammatory;inhibitor;Interleukin-12;Kaposi Sarcoma;lenalidomide;Liposomal Doxorubicin;Malignant Neoplasms;Monitor;Monoclonal Antibodies;Multicentric Angiofollicular Lymphoid Hyperplasia;Natural History;Nivolumab;novel therapeutics;Pathogenesis;patient subsets;Patients;PD-1 inhibitors;pembrolizumab;Pharmaceutical Preparations;Phase;pomalidomide;prevent;primary effusion lymphoma;Process;Prodrugs;Protocols documentation;receptor;Relapse;Research Personnel;response;rituximab;Sarcoma;Surface Antigens;Syndrome;Testing;tocilizumab;tool;translational study;tumor;United States Food and Drug Administration;Valganciclovir;Virus;Work;Zidovudine

PROJECT_TITLE: Clinical Trials of Patients with AIDS-Related Malignancies


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunization;Immunotherapy;Liver Cancer;Liver Disease;Lung;Lung Cancer;Neuroblastoma;Neurosciences;Orphan Drug;Ovarian Cancer;Pancreatic Cancer;Pediatric;Pediatric Cancer;Rare Diseases;Women's Health Research

PI_NAMEs: HO, MITCHELL  (contact)

PROJECT_TERMS: Animal Model;anti-cancer research;Antibodies;antibody engineering;anticancer activity;Antigen Targeting;Antigens;Antineoplastic Agents;B lymphoid malignancy;Bioluminescence;Biomedical Engineering;Camels;Cancer Biology;Cancer Family;cancer imaging;cancer immunotherapy;Cancer Patient;cancer therapy;CAR T cell therapy;CCR;CD276 gene;Cell surface;Cell Surface Proteins;Cell Therapy;Cells;chimeric antigen receptor T cells;Clinical;clinical center;Clinical Investigator;Clinical Trials;Collaborations;Combined Modality Therapy;Communication;Cooperative Research and Development Agreement;Coupled;density;design;Development;Disease;Disease remission;Dromedaries;drug development;Engineering;Engraftment;Epitopes;Event;exhaustion;Exhibits;extracellular;Female;Flow Cytometry;Funding;Gene Activation;Generations;Genes;Glypican;GPC3 gene;GPI Membrane Anchors;Heparan Sulfate Proteoglycan;hepatocellular carcinoma cell line;Human;IL7 gene;Immunization;immunogenic;Immunophenotyping;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Infiltration;Integral Membrane Protein;Interleukin 7 Receptor;Interleukin-2;Intramural Research Program;Journals;Laboratories;liver cancer model;Lymphocyte Activation;Malignant Childhood Neoplasm;Malignant mesothelioma;Malignant neoplasm of liver;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Mediating;Membrane;Memory;mesothelin;Mesothelioma;Modeling;Molecular Biology;Monitor;Mus;nanobodies;National Cancer Institute;Nature;Neuroblastoma;novel;novel anticancer drug;Paper;Pathway interactions;Patients;Pediatric Neoplasm;Phage Display;Primary carcinoma of the liver cells;programmed cell death protein 1;programs;Proteomics;Publishing;rational design;receptor expression;Research;Resources;Role;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;Site;Solid Neoplasm;Stat5 protein;stemness;syndecan;T-Cell Activation;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic antibodies;therapeutic target;transcriptome;transcriptome sequencing;tumor;Tumor Antigens;Tumor Volume;tumor xenograft;United States National Institutes of Health;Western Blotting;Work

PROJECT_TITLE: Development of antibody engineering-based cancer therapies


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Immunotherapy;Radiation Oncology;Regenerative Medicine;Women's Health Research;Wound Healing and Care

PI_NAMEs: WINK, DAVID  (contact)

PROJECT_TERMS: 4T1;Acute;Alzheimer's Disease;angiogenesis;Animal Model;Area;Biological;Cancerous;carcinogenesis;Cell Communication;cell type;Cells;Chemicals;Chronic;Clinical;Combined Modality Therapy;conventional therapy;cytokine;Dendritic Cells;Disease;epidemiology study;Generations;Growth;HIF1A gene;Immune;Immune signaling;immunomodulatory therapies;immunoregulation;Immunotherapy;improved;In Situ;Inflammation;Inflammation Process;inhibitor;Interleukin-10;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Microglia;MMP9 gene;Modification;Molecular;Neoplasm Metastasis;NG-Nitroarginine Methyl Ester;Nitric Oxide;Nitric Oxide Synthase;Nitric Oxide Synthetase Inhibitor;novel marker;novel therapeutics;Outcome;Oxidation-Reduction;Peptide Hydrolases;Play;Primary Neoplasm;Process;Prognosis;programmed cell death ligand 1;programs;Proteins;Radiation;Radiation therapy;Regulation;Research;response;restoration;Role;small molecule;Testing;Therapeutic;therapy outcome;Thrombospondin 1;TIMP1 gene;Tissue Inhibitor of Metalloproteinase-1;TNFRSF5 gene;TP53 gene;Transforming Growth Factor beta;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;wound healing

PROJECT_TITLE: Redox Mechanism Process of Angiogenesis and Wound Healing


NIH_SPENDING_CATS: Breast Cancer;Cancer;Prevention;Radiation Oncology;Women's Health Research

PROJECT_TERMS: Agonist;Antioxidants;Biological Markers;cancer therapy;cancer type;Cessation of life;chemotherapy;Development;Dithiolthione;Goals;Immunomodulators;Inflammation;Inflammatory;Inflammatory Response;inhibitor;kinase inhibitor;Malignant Breast Neoplasm;Metabolic;Modeling;Myocardial Infarction;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutics;Nucleoside Diphosphate Kinase A;Oncogenic;Oxidation-Reduction;Pathway interactions;persulfides;Pharmaceutical Preparations;phosphatase inhibitor;Phosphoric Monoester Hydrolases;prevent;Prevention;Property;Protein Phosphatase 2A Regulatory Subunit PR53;Radiation therapy;Risk;Set protein;side effect;Stroke;Testing;Therapeutic;tumor;Tumor Suppressor Proteins;Ulcer;Work

PROJECT_TITLE: Inflammation and cancer treatment


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Estrogen;Immunotherapy;Prostate Cancer;Urologic Diseases;Women's Health Research

PI_NAMEs: PALENA, CLAUDIA  (contact)

PROJECT_TERMS: Adenocarcinoma;Advanced Malignant Neoplasm;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;antagonist;cancer cell;Cancer Etiology;Carcinoma;Castration;Cell Adhesion;Cell Death Induction;cell motility;Cell Nucleus;Cells;Cessation of life;chemotherapy;Clinical;Cytolysis;Data;Diagnosis;Dimerization;Disease Progression;effector T cell;enzalutamide;Epithelial Cells;Epithelium;Estrogen Receptors;experience;Fulvestrant;Future;Glucocorticoid Receptor;Goals;hormone receptor-positive;Immune;Immunotherapy;In Vitro;in vivo;Invaded;Investigation;Laboratories;Link;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;men;Mesenchymal;Metastatic breast cancer;Modality;Motility;N-Cadherin;Natural Killer Cells;neoplastic cell;Neuroendocrine Prostate Cancer;novel;novel therapeutic intervention;Nude Mice;overexpression;Patients;pharmacologic;Phenotype;Postmenopause;Predisposition;prevent;prostate cancer cell;prostate cancer model;Prostate Cancer therapy;Radiation;Receptor Signaling;Reducing Agents;Resistance;resistance mechanism;response;Role;targeted treatment;Therapeutic;Time;transcriptome sequencing;tumor;Up-Regulation;Vimentin;Woman;Xenograft procedure

PROJECT_TITLE: Novel Targets for Immunotherapy


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cervical Cancer;Genetics;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

PI_NAMEs: SCHLOM, JEFFREY  (contact)

PROJECT_TERMS: Adenoviruses;Agonist;anti-PD-1;anti-PD-L1;Antibodies;antigen processing;Antigen-Presenting Cells;arm;biomarker signature;Bypass;cancer immunotherapy;Cancer Patient;cancer type;Carcinoma;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cervix Neoplasms;chemokine;Clinical;Clinical Trials;Colon Carcinoma;Combined Modality Therapy;CXCL13 gene;cytokine;Cytolysis;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data Set;design;Development;docetaxel;Enhancers;Epigenetic Process;Epitopes;Evaluation;Extracellular Matrix;Goals;Gorilla gorilla;Histone Deacetylase Inhibitor;Human;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;humanized mouse;Immune;immune checkpoint blockade;Immune response;Immune system;immunogenic;Immunotherapeutic agent;Immunotherapy;Impairment;Infiltration;Interferon Type II;Interferons;Interleukin-12;Janus kinase;Ligands;Lung;Macrophage;Major Histocompatibility Complex;Malignant Neoplasms;Mammary Neoplasms;Mediating;Modeling;Monitor;Mus;Mutation;Myelogenous;Necrosis;neoplastic cell;neutrophil;novel therapeutics;Oncoproteins;Pathway interactions;Patients;Pattern;Peptides;Peripheral Blood Mononuclear Cell;Persons;Phase;Phenotype;Play;pre-clinical;Pre-Clinical Model;preclinical study;Predisposition;prevent;Preventive vaccine;programmed cell death ligand 1;programs;Proteome;Recombinants;Refractory;Regulatory T-Lymphocyte;Resistance;response;Role;Sarcoma;Signal Transduction;Solid;Solid Neoplasm;Spleen;STAT protein;success;synergism;T-Lymphocyte;T-Lymphocyte Epitopes;targeted delivery;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;transcriptome;transcriptomics;Transforming Growth Factor beta;tumor;Tumor Cell Necrosis;tumor eradication;tumor microenvironment;Tumor Volume;Tumor Weights;United States;Up-Regulation;Vaccines;Viral

PROJECT_TITLE: Strategies for Cancer Immunotherapy Development: Preclinical Studies


NIH_SPENDING_CATS: Aging;Cancer;Radiation Oncology

PI_NAMEs: MITCHELL, JAMES  (contact)

PROJECT_TERMS: Acute;Awareness;Biological Markers;cancer risk;carcinogenesis;Chronic;Data;Diet;dosimetry;effective intervention;Evaluation;exposed human population;Exposure to;extend lifespan;External Beam Radiation Therapy;Face;FDA approved;FRAP1 gene;Funding;Government Agencies;Human;Intensity-Modulated Radiotherapy;interest;Journals;Life;life span;Malignant Neoplasms;Mediating;Monitor;Mus;Normal tissue morphology;Nuclear Warfare;Patients;Persons;Pharmaceutical Preparations;Population;Primary carcinoma of the liver cells;Process;Publishing;Radiation;Radiation Dose Unit;Radiation Injuries;Radiation Oncology;Radiation Protection;Radiation therapy;Radiation-Protective Agents;Reagent;Research;Risk;Second Primary Neoplasms;Sirolimus;stem;Survivors;tempol;Time;tumor;tumorigenesis;Weight;Whole-Body Irradiation

PROJECT_TITLE: Protection against Radiation-Induced Carcinogenesis


PI_NAMEs: DAAR, IRA  (contact)

PROJECT_TERMS: Adhesions;Affect;angiogenesis;Apical;autism spectrum disorder;Binding;Biochemical;Biological Models;Breast;Cancer cell line;Cell Adhesion;Cell Fate Control;Cell Line;Cell Lineage;Cell membrane;cell motility;Cell Physiology;Cell-Cell Adhesion;Cells;Cephalic;Colon;Complex;Contact Inhibition;Data;Defect;Development;Developmental Process;Disease;Disseminated Malignant Neoplasm;Distal;E-Cadherin;Embryo;Embryonic Development;Endosomes;Environment;Eph Family Receptors;Ephrins;Epithelial Cells;Event;experimental study;Family;Family member;flotillin;gene product;GTPase-Activating Proteins;Histologic;Human;improved;insight;Intercellular Junctions;interest;Invaded;Investigation;Laboratories;Ligands;Locomotion;loss of function;Lung;Malignant Neoplasms;Maps;Mediating;Melanoma;member;Membrane;Metalloproteases;migration;Morphogenesis;Morphology;Motility;Movement;mutant;Neoplasm Metastasis;neoplastic;Neural Crest;Neural Crest Cell;Neural tube;Neural Tube Closure;Neuroblastoma;novel;Ovarian;Pathway interactions;planar cell polarity;Play;Predisposition;Process;Prosencephalon;Prostate;Proteins;rab11 protein;Rana;receptor;Receptor Protein-Tyrosine Kinases;Recycling;Research;retinal progenitor cell;Role;scaffold;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;System;Telencephalon;Tissues;tumorigenesis;Tyrosine Phosphorylation;Visual Fields;Xenopus;Xenopus oocyte

PROJECT_TITLE: Signaling Mechanisms of EphrinB1 in Cell Adhesion, Migration and Invasion


NIH_SPENDING_CATS: Ataxia Telangiectasia;Brain Disorders;Cancer;Genetics;Neurodegenerative;Neurosciences;Pediatric;Pediatric Cancer;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: NUSSENZWEIG, ANDRE A. (contact)

PROJECT_TERMS: Age related pathologies;Amino Acids;Ataxia;Ataxia Telangiectasia;ataxia telangiectasia mutated protein;ataxia-telangiectasia like disorder;Bacterial Artificial Chromosomes;Cancer Etiology;cancer predisposition;Characteristics;Chromosomal Instability;Chromosomal translocation;Chromosome Deletion;Complex;Defect;Derivation procedure;Detection;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;Event;Genes;Genome Stability;Genomic Instability;Hereditary Malignant Neoplasm;Human;humanized mouse;Immune System Diseases;immune system function;immunodeficiency;improved;in vivo;Individual;Infertility;Inherited;insight;Meiotic Recombination;mouse model;Mus;Mutate;Mutation;Nijmegen Breakage Syndrome;null mutation;Phenotype;Phosphorylation;Predisposition;Radiation Tolerance;reconstitution;recruit;Research Proposals;response;Series;Signal Transduction;Syndrome;tissue degeneration;Transgenic Mice;transmission process;Tumor Suppression

PROJECT_TITLE: Relationship between DNA damage detection and signaling


NIH_SPENDING_CATS: Biotechnology;Cancer;Cervical Cancer;Immunization;Immunotherapy;Infectious Diseases;Ovarian Cancer;Radiation Oncology;Rare Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

PI_NAMEs: HODGE, JAMES  (contact)

PROJECT_TERMS: Adoptive Cell Transfers;Antitumor Response;cell killing;Cell Line;Cellular Stress;Cervix Carcinoma;Cessation of life;chelation;chemotherapy;Cisplatin;clinically relevant;Colorectal Cancer;Cytolysis;External Beam Radiation Therapy;Gamma Rays;Goals;Head and Neck Squamous Cell Carcinoma;Human;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;immunogenic;In Vitro;Label;Low Dose Radiation;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Modeling;Monoclonal Antibodies;neoplastic cell;novel;Phenotype;Pre-Clinical Model;preclinical study;Predisposition;Prostate Cancer therapy;Radiation;Radiation Dose Unit;Radio;radio frequency;Radioisotopes;receptor;Reporting;retroviral transduction;Source;Squamous cell carcinoma;standard of care;Surface;System;T-Cell Receptor;T-Lymphocyte;therapeutic HPV vaccine;thermal stress;TNFRSF10B gene;tumor;Vaccine Therapy;Vaccines

PROJECT_TITLE: Vaccine and radiation for the therapy of human cancers


NIH_SPENDING_CATS: Cancer

PI_NAMEs: LIPKOWITZ, STANLEY  (contact)

PROJECT_TERMS: Biochemical;cancer cell;Carcinoma;CBL Protein;Clinical;Collaborations;Complex;Down-Regulation;Epidermal Growth Factor Receptor;Epithelium;ERBB2 gene;Human;inhibitor;Investigation;Laboratories;Malignant Neoplasms;Mammalian Cell;Mediating;member;Mus;mutant;Mutation;overexpression;Pathogenesis;Protein Family;Protein Tyrosine Kinase;Proteins;Receptor Protein-Tyrosine Kinases;Regulation;Research Personnel;Ring Finger Domain;Signal Pathway;Signal Transduction;Structure;trafficking;tumor;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Cbl Proteins as Regulators of Tyrosine Kinase Signaling


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: APLAN, PETER  (contact)

PROJECT_TERMS: 3' Untranslated Regions;ABCB1 gene;ABL1 gene;Acute leukemia;acute T-cell lymphoblastic leukemia cell;Alleles;Animal Model;Apoptosis;B-Cell Leukemia;B-Lymphocytes;Candidate Disease Gene;Cell Line;cell type;Cells;Chemoresistance;Clinical;Collaborations;Complex;CRISPR screen;Cytarabine;Cytidine;DCK gene;DHFR gene;DNA biosynthesis;DNA replication fork;DNA Resequencing;DNMT3a;Epigenetic Process;Etoposide;exome sequencing;experimental study;Gene Dosage;Gene Expression Profile;Generations;Genes;Genetic;Genetically Engineered Mouse;Genets;Genomic DNA;Growth;helicase;Hematopoietic stem cells;Human;human disease;Immunophenotyping;Impairment;In Vitro;in vivo;Insertional Mutagenesis;Knock-in;Length;leukemia;leukemia/lymphoma;leukemic transformation;Licensing Factor;Ligands;Loss of Heterozygosity;Lymphoblastic Leukemia;Lymphoma;Maintenance;Malignant Neoplasms;Manuscripts;Methotrexate;Modeling;Mouse Strains;Mus;Mutate;Mutation;Myelogenous;NOTCH1 gene;novel;novel strategies;NUP214 gene;NUP98 gene;Pathway interactions;Pattern;Phenotype;Phosphorylation;Phosphotransferases;Prednisone;Preparation;Proliferating;Proteins;PTPN1 gene;Publishing;Recurrence;Reporting;Resistance;retroviral transduction;RNA Splicing;Sampling;small hairpin RNA;stem;stem cell self renewal;T-Cell Leukemia;T-Lymphocyte;TCF3 gene;thymocyte;TOP1 gene;Transgenes;Tumor Suppressor Genes;Vincristine;whole genome

PROJECT_TITLE: Collaborative Pathways that Lead to Leukemia