PI_NAMEs: BERGER, ADAM C (contact)

PROJECT_TERMS: Accountability;Achievement;advanced system;Advisory Committees;anti-cancer research;Area;Attention;authority;Award;base;Basic Science;Bioinformatics;Businesses;Cancer Center Support Grant;Cancer Institute of New Jersey;Clinical Research;Clinical Trials;Collaborations;Collection;Communication;Computational Science;Consultations;Core Facility;cost effective;cost effectiveness;Data;Databases;Dedications;Development;Direct Costs;Doctor of Philosophy;Education and Outreach;Ensure;Evaluation;Exercise;expectation;experience;experimental study;Faculty;Faculty Recruitment;Feedback;Funding;genome sciences;Genomics;Goals;Grant;Growth;Human Resources;improved;Individual;innovation;Institution;instrument;instrumentation;Investments;Joints;Leadership;mass spectrometer;meetings;member;Mission;Modernization;NCI-Designated Cancer Center;Needs Assessment;Office of Administrative Management;operation;Organoids;Outcome;Performance;preference;Process;Productivity;programs;Publications;Published Comment;Recommendation;Reporting;Research;Resource Sharing;Resources;satisfaction;Schedule;Schools;Secure;Services;Strategic Planning;Surveys;Technology;Translational Research;Universities;Update;voucher

PROJECT_TITLE: Shared Resource Management


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

ORG_CITY: Newark

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Not required per PAR-21-321 (Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)

PI_NAMEs: LIBUTTI, STEVEN K. (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;Advocate;Basic Science;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer health equity;Cancer Institute of New Jersey;cancer prevention;cancer therapy;career;Catchment Area;Cell Therapy;Clinical;clinical care;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community building;community engagement;Community Outreach;Consultations;Data;Decision Making;Development;Doctor of Philosophy;Education;Education and Outreach;effectiveness evaluation;empowerment;Ensure;equity, diversity, and inclusion;Evaluation;evidence base;Evidence based practice;Evolution;Faculty;Fostering;Funding;Genomics;Goals;Grant;Growth;Health;health equity promotion;Immunologic Monitoring;Immunology;implementation evaluation;improved;Individual;innovation;insight;Institution;Investments;Joints;Leadership;Malignant Neoplasms;meetings;Mentorship;Metabolism;Minority;Mission;NCI-Designated Cancer Center;neoplasm resource;New Jersey;novel;Nurses;operation;Outcome;outreach;Patient Care;Patients;Peer Review;Persons;Physicians;Play;Population Sciences;Prevention;Process;programs;recruit;Reporting;Research;Research Activity;Research Personnel;research vision;Resource Sharing;Resources;Rest;Role;Schedule;Science;screening;Screening for cancer;Strategic Planning;success;Technology;Therapeutic Intervention;Therapeutic Studies;Training and Education;Translational Research;Trust;tumor immunology;tumor metabolism;underserved area;Universities;Vision;Work

PROJECT_TITLE: Leadership, Planning and Evaluation

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety

PI_NAMEs: SAUNDERS, TRACIE  (contact)

PROJECT_TERMS: Adult;Agreement;anti-cancer research;Area;Attention;Budgets;Businesses;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Institute of New Jersey;cancer research center director;Catchment Area;Childhood;Clinical;Clinical Data;Clinical Investigator;Clinical Management;Clinical Oncology;Clinical Protocols;Clinical Research;clinical trial enrollment;Clinical Trials;community engagement;Community Hospitals;Community Outreach;Data;data management;Data Management Resources;Development;Disease;Education;Enrollment;faculty mentor;Fostering;Funding;Future;Goals;Grant;Growth;Health;Health system;Hospitals;Housing;Human;Infrastructure;insight;Institution;Intervention;investigator-initiated trial;Leadership;Location;member;Minority Enrollment;Modeling;Monitor;NCI-Designated Cancer Center;New Jersey;Office Management;Oncology;oncology service;operation;organizational structure;Patients;Phase;Principal Investigator;programs;Protocols documentation;quality assurance;Regulatory Affairs;Reporting;Research;Research Activity;Research Personnel;Resources;Role;Safety;screening;Services;Site;software systems;Support System;System;Therapeutic;Therapeutic Intervention;Training;Translational Research;treatment trial;Underrepresented Populations;Universities;Work

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Services;Patient Safety

PI_NAMEs: JABBOUR, SALMA  (contact)

PROJECT_TERMS: Adverse event;Advocate;Age;Agreement;anti-cancer research;Area;authority;Cancer Center Support Grant;cancer clinical trial;Cancer Institute of New Jersey;cancer research center director;Cancer Therapy Evaluation Program;Catchment Area;Clinical;Clinical Data;Clinical Oncology;Clinical Protocols;Clinical Research;Clinical Trials;Community Outreach;Data;data management;design;Discipline;Disease;Ensure;Ethnic Origin;Event;expedited review;Funding;Gender;Goals;Guidelines;Health;Health Sciences;Health system;Hospitals;Human;Industry;Institution;Institutional Review Boards;Intervention;Intervention Trial;investigator-initiated trial;Laws;Leadership;Malignant Neoplasms;Mission;Monitor;NCI-Designated Cancer Center;Notification;Oncology;oncology service;patient population;Patients;Peer Review;Performance;Population;Process;Protocols documentation;Race;Recommendation;Reporting;Research;Resources;Risk;Safety;Scientist;Site;sound;Specialist;Supervision;System;Therapeutic Intervention;Therapeutic Trials;United States National Institutes of Health;Work;working group;Writing

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Machine Learning and Artificial Intelligence;Pediatric;Rare Diseases

ORG_CITY: Aurora

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative We seek to understand why some children with single ventricle heart disease fail after surgical procedures. Currently, images from echocardiography, catheterizations, and cardiovascular magnetic resonance are being used to qualitatively choose the best surgical approach for these patients. In this project, we aim to quantitatively determine the most optimal surgical repair for each patient by simulating different surgical repairs and comparing the post-surgical hemodynamics.

PI_NAMEs: HEDJAZI MOGHARI, MEHDI  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;Algorithms;Anastomosis - action;Anatomy;Anesthesia procedures;Applications Grants;automated segmentation;Blood;Blood flow;blood flow measurement;Blood Pressure;Breathing;Cardiac;Cardiac Surgery procedures;Cardiovascular system;Catheterization;Cessation of life;Child;Circulation;Compensation;Complex;Congenital Abnormality;congenital heart abnormality;convolutional neural network;Data;Data Set;Decision Making;design;Echocardiography;Elasticity;Elements;expiration;Friction;Heart;heart function;heart imaging;heart motion;hemodynamics;Image;image registration;imaging modality;improved;Lead;Life;Liquid substance;Lung;Magnetic Resonance;Magnetic Resonance Imaging;mathematical methods;Measures;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;Motion;Myocardium;Newborn Infant;Operative Surgical Procedures;Outcome;Palliative Surgery;Patient Outcomes Assessments;Patients;Phase;Positioning Attribute;Property;Radial;Rationalization;reconstruction;repaired;Research;respiratory;segmentation algorithm;simulation;Single ventricle congenital heart disease;spatial relationship;Surface;Surgeon;Surgical Models;Survival Rate;System;three-dimensional modeling;Time;two-dimensional;United States;vector;Venous system;virtual surgery;viscoelasticity

PROJECT_TITLE: Simulating Cardiac Surgery for Children with Severe Congenital Heart Disease

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Genetics;Hematology;Human Genome;Infectious Diseases;Kidney Disease;Microbiome;Nutrition;Organ Transplantation;Transplantation

ORG_CITY: MINNEAPOLIS

ORG_NAME: HENNEPIN HEALTHCARE RESEARCH INSTITUTE

ORG_STATE: MN

PHR: Unfortunately, it is challenging to achieve and maintain adequate immunosuppression over time for kidney transplant patients due to variation in the blood levels of immunosuppressive medications. This study will determine if variations in the microbes in the stool are associated with blood levels of immunosuppressive medication named mycophenolate mofetil. We will also determine if variations in the microbes in the human body lead to higher blood levels of this medication and thereby explain the side effects of this medication seen commonly in kidney transplant patients.

PI_NAMEs: ISRANI, AJAY K (contact);JACOBSON, PAMALA A

PROGRAM_OFFICER_NAME: SWEET, STUART CHARLES

PROJECT_TERMS: absorption;Accounting;Acute;allograft rejection;Anemia;Antibiotics;Area Under Curve;Bacteroides;Beta-glucuronidase;Biliary;Blood;Clinical;Clostridium perfringens;cohort;Diarrhea;Diet;Dose;drug disposition;Drug Kinetics;Enrollment;Escherichia coli;Excretory function;experience;Exposure to;fecal microbiome;fecal transplantation;Feces;fungus;Future;Genes;Genetic Transcription;genetic variant;Glomerular Filtration Rate;Glucuronides;Goals;gut bacteria;gut microbes;gut microbiome;gut microbiota;Hematology;Hour;Human body;Hydrolysis;Immune;Immunosuppression;Immunosuppressive Agents;improved;innovation;inter-individual variation;Investigation;Kidney;kidney allograft;Kidney Transplantation;Lead;Leukopenia;Measures;metatranscriptomics;Methods;Microbe;microbial;microbiome;microbiome composition;microbiome research;microbiota;microbiota profiles;Modeling;multidisciplinary;mycophenolate mofetil;Mycophenolic Acid;Names;Oral;Outcome;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Pilot Projects;Plasma;Population;predictive test;prospective;Prospective cohort;Randomized;Recycling;Ruminococcus;Sampling;Shotgun Sequencing;side effect;Streptococcus Group B;Tacrolimus;Text Messaging;Time;Toxic effect;transcriptome sequencing;Transplant Recipients;Transplantation;Variant;Work

PROJECT_TITLE: Gut Microbiota and Effect on Immune Suppressants in Transplantation

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SAN ANTONIO

ORG_NAME: SOUTH TEXAS VETERANS HEALTH CARE SYSTEM

ORG_STATE: TX

PHR: Diabetes is a pandemic, emerging as one of the most prevalent diseases among people aged 20 years and older in the United States. The demographics of veteran population fall in this age group. In those, 25% are afflicted with diabetes. Currently, a significant proportion of VA health care resources are devoted to older veterans, whom constitute over 45% of the patients. The cost of diabetes in the US in 2017 was $327 billion and VA spends $1.5 billion annually. Diabetic nephropathy (DN) is the leading cause of end stage renal disease (ESRD) accounting for 44% new cases each year. Current therapies only delay the progression to ESRD and do not arrest the disease. Therefore, there is urgent need for new therapeutic approaches for DN. This proposal will explore the therapeutic modality of a newly identified translational variant of PTEN (phosphatase and tensin homolog deleted in chromosome 10), PTEN-Long, in rodent models of DN. Also, its role in activation of platelet- derived growth factor receptor-b for progression of DN will be investigated.

PI_NAMEs: GHOSH CHOUDHURY, GOUTAM ;SHARMA, KUMAR  (contact)

PROJECT_TERMS: 20 year old;Accounting;Address;Affect;age group;AKT inhibition;Automobile Driving;Binding;cell injury;Cell Membrane Permeability;Cells;Chromosome 10;Codon Nucleotides;Complex;Complications of Diabetes Mellitus;cost;CRISPR/Cas technology;Data;db/db mouse;demographics;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Nephropathy;diabetic rat;Disease;Dissociation;Down-Regulation;End stage renal failure;Epithelial Cells;Event;Exposure to;falls;Fibronectins;FRAP1 gene;Glucose;Healthcare;Human;Hyperglycemia;Hypertrophy;Immune;Immunofluorescence Immunologic;Immunohistochemistry;Immunoprecipitation;inhibitor;Kidney;kidney cell;kidney cortex;Kidney Diseases;Knock-out;Maps;mesangial cell;Methods;military veteran;Modality;Modeling;Molecular;morphometry;Mus;novel;novel therapeutic intervention;pandemic disease;Pathogenesis;Pathologic;Pathology;Patients;Permeability;Persons;Phosphorylation;Phosphotransferases;Plasminogen Activator Inhibitor 1;Platelet Activation;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor Receptor;prevent;Process;Protein Dephosphorylation;protein expression;Protein Isoforms;Protein Tyrosine Kinase;Proteins;PTEN gene;Recombinant Proteins;Recombinants;Regulation;Renal function;Renal Tissue;Reporting;Resources;response;Rodent;Rodent Model;Role;Signal Transduction;Small Interfering RNA;small molecule;Streptozocin;Techniques;Testing;Therapeutic;Therapeutic Agents;therapeutic protein;Transfection;transfection/expression vector;Transforming Growth Factors;Translations;Tricarboxylic Acids;Tubular formation;Type 2 diabetic;Tyrosine Phosphorylation;United States;Variant;Veterans;Western Blotting

PROJECT_TITLE: Mechanisms of Renal Cell Injury


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Disturbances in motivation are major determinants of poor functional outcome in a large number of Veterans with schizophrenia and bipolar disorder. Despite their clear public health significance, available treatments for these motivational disturbances are minimally effective. To facilitate treatment development, this translational research project will investigate four subcomponents of an affective neuroscience model of motivation: Reward Receipt, Reward anticipation, Effort Valuation, and Goal-directed action selection. We will test hypothesized differences between schizophrenia (n = 60), bipolar disorder (n = 60), and control (n = 60) groups on functional Magnetic Resonance Imaging and behavioral motivation tasks that assess these four subcomponents. We will also examine relations between performance on these tasks and community functioning. Results will help specify brain-based reward-processing impairments that contribute to motivational disturbances, and guide both clinical and preclinical studies of new treatments.

PI_NAMEs: WYNN, JONATHAN  (contact)

PROJECT_TERMS: Acute;affective neuroscience;Anterior;Award;Behavior;Behavioral;behavioral response;Bipolar Disorder;brain based;Brain region;cingulate cortex;Clinical;Clinical assessments;Clinical Research;Cognition;Cognitive;cognitive control;cognitive process;Communities;comparison control;Complex;Cues;Data;Decision Making;Disabling;Disease;Dorsal;Electrophysiology (science);Functional impairment;functional improvement;Functional Magnetic Resonance Imaging;functional outcomes;Goals;Impairment;Incentives;indexing;interest;Methodology;Modeling;Moods;Motivation;neural correlate;Neurosciences Research;Outcome;Outpatients;Participant;Patient Self-Report;Patients;Pattern;Performance;pleasure;preclinical study;Prefrontal Cortex;Productivity;programs;prospective;Public Health;Reaction Time;recruit;relative cost;Research;Research Project Grants;response;reward anticipation;reward processing;Rewards;Sampling;Schizophrenia;severe mental illness;Signal Transduction;Specific qualifier value;Testing;Theoretical model;therapy development;Translating;Translational Research;translational research program;Ventral Striatum;Veterans

PROJECT_TITLE: Affective Neuroscience of Motivation in Schizophrenia and Bipolar Disorder

STUDY_SECTION: MHBB

STUDY_SECTION_NAME: Mental Health and Behavioral Science B[MHBB]


FUNDING_MECHANISM: OTHERS

ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: Primary sclerosing cholangitis (PSC) is a rare, cholestatic liver disease characterized by bile duct stricturing, biliary senescence and liver fibrosis, and can be complicated by cirrhosis, portal hypertension and microcirculatory disturbances that increase mortality risks in these patients. U.S. Veterans have increased incidences of liver disease and cirrhosis, that can be coupled with portal hypertension, which leads to enhanced morbidity and mortality in this demographic. The goal of this proposal is to demonstrate that endothelin (ET) signaling, mediated by transforming growth factor (TGF)-β1 that can, in turn, enhance ET expression, increases biliary senescence and liver vascular angiogenesis through autocrine and paracrine mechanisms. Furthermore, targeting ET/TGF-β signaling may prove therapeutic for the treatment of PSC.

PI_NAMEs: KENNEDY, LINDSEY  (contact)

PROJECT_TERMS: ambrisentan;angiogenesis;Angiogenic Factor;Angiopoietin-2;antagonist;Architecture;autocrine;Automobile Driving;bile duct;bile stricture;Biliary;Biology;Blood;Blood capillaries;blood vessel development;Blood Vessels;career;Cell Communication;cell growth;Cell Proliferation;Cell Separation;Cellular biology;Cholangiocarcinoma;cholangiocyte;Cholestasis;Chronic;Cirrhosis;Collagen;comparison control;Complex;Corrosion Casting;Coupled;Data;Deposition;Development;Disease Progression;Down-Regulation;Duct (organ) structure;Endothelin;Endothelin-1;Endothelin-2;Endothelin-3;Epithelial Cells;Epithelium;Extrahepatic;FDA approved;Feedback;Goals;Growth;Hepatic;Hepatic Stellate Cell;HIF1A gene;Human;in vivo;Incidence;Inflammation;Injections;Injury;Ink;Knock-out;Knockout Mice;Ligation;Liver;Liver Cirrhosis;Liver diseases;Liver Fibrosis;liver inflammation;liver injury;liver transplantation;Malignant neoplasm of liver;Mediating;Mentors;Mentorship;MicroRNAs;Modeling;Morbidity - disease rate;mortality;mortality risk;mouse model;Multi-Drug Resistance;Mus;novel;novel therapeutics;Nutrient;paracrine;Patients;Pharmaceutical Preparations;Portal Hypertension;Portal Pressure;primary sclerosing cholangitis;Proliferating;Pulmonary Hypertension;Research;Research Proposals;restoration;Risk;Role;Safety;senescence;senescence associated secretory phenotype;Signal Transduction;symposium;Techniques;Therapeutic;therapeutically effective;Tissues;Training;Transforming Growth Factor beta;Transforming Growth Factors;vascular bed;Vascular Endothelial Cell;Vasoconstrictor Agents;VEGFA gene;Veterans;Work

PROJECT_TITLE: Cholangiocyte-Derived Endothelin Signaling Mediates Biliary Injury and Liver Fibrosis


ORG_CITY: NORTHPORT

ORG_NAME: NORTHPORT VA MEDICAL CENTER

ORG_STATE: NY

PHR: The CDC estimates more than 30 million Americans have chronic kidney disease (CKD), with a disproportionate burden on U.S. Veterans (prevalence a third higher than the general population), and we have no sustainable therapeutic strategies to prevent or reverse CKD. As such, the Department of Veterans Affairs and the current White House administration underscored the importance of new therapeutics. Podocytes are epithelial cells in the kidney whose major function is the maintenance of the kidney filtration barrier to prevent CKD. Injury to podocytes has been implicated in many glomerular diseases, but therapies targeting podocyte dysfunction are limited. Our proposal will address this current gap in the field by developing an integrated framework to optimize lead novel small molecule agonists to a critical regulator of gene expression (Krüppel- Like Factor 15) and test their therapeutic role in preclinical proteinuric models. Therefore, the studies we propose are highly significant and clinically relevant to the Department of Veterans Affairs.

PI_NAMEs: MALLIPATTU, SANDEEP K (contact)

PROJECT_TERMS: absorption;Actins;Activities of Daily Living;Adult;Agonist;Albuminuria;American;analog;Attenuated;Biological Assay;Cardiovascular Diseases;cardiovascular risk factor;Cells;Cellular Stress;Centers for Disease Control and Prevention (U.S.);Characteristics;Chemicals;Chronic Kidney Failure;Clinical Research;clinically relevant;common treatment;Cytoskeleton;Data;design;Diabetic Nephropathy;Disease;Dose;Drug Kinetics;Epithelial Cells;Excretory function;Filtration;Focal and Segmental Glomerulosclerosis;Functional disorder;Gene Expression;General Population;ginsenoside M1;glomerular filtration;Glucocorticoids;Goals;Heart Hypertrophy;high throughput screening;Human;improved;In Vitro;in vivo;Injury;Injury to Kidney;interest;Kidney;Kidney Diseases;knock-down;Laboratories;Lead;lead optimization;lipid biosynthesis;loss of function;Luciferases;Maintenance;Mediating;Metabolism;military veteran;Modeling;Morphology;mouse model;Mus;Neurodegenerative Disorders;novel;novel lead compound;novel therapeutics;Organoids;Pathway interactions;Patients;pharmacokinetics and pharmacodynamics;podocyte;pre-clinical;Pre-Clinical Model;preclinical study;Predisposition;Prevalence;prevent;promoter;Property;Regulator Genes;Renal glomerular disease;Reporting;repository;Research;Role;scaffold;Signal Transduction;small molecule;Specificity;Structure;Structure-Activity Relationship;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Toxic effect;transcription factor;transcriptome sequencing;Treatment Efficacy;United States;United States Department of Veterans Affairs;Veterans

PROJECT_TITLE: Small Molecule KLF15 Agonists for Kidney Disease


ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PHR: Acute myeloid leukemia (AML) is a life threatening disease that kills thousands of Americans each year including Veterans. We have recently demonstrated that the protein mammalian target of rapamycin 2 (MTORC2) is constitutively activated in human AML cell lines and primary patient materials. Here we will study how this occurs and determine if inhibiting MTORC2 will lead to better therapy for AML.

PI_NAMEs: CARROLL, MARTIN  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Affect;American;Binding;Biochemical Pathway;Biological Assay;c-myc Genes;cancer cell;Cell Count;Cell Cycle Regulation;cell growth;Cell Line;Cell Proliferation;Cell Survival;cell transformation;chemotherapy;chromatin immunoprecipitation;Clinical;Clinical Trials;combinatorial;Complex;Cytarabine;cytotoxic;Data;Disease;DNA;Drug Combinations;Engraftment;Equilibrium;Etoposide;FLT3 gene;FLT3 inhibitor;FOXO3A gene;FRAP1 gene;Generations;Growth Factor;Hematopoietic Neoplasms;Human;IL3 Gene;improved;In Vitro;in vivo;Individual;inhibitor;Inositol;insulin signaling;Laboratories;Lead;Leukemic Cell;leukemic stem cell;Life;Metabolic;Methodology;Methods;Modeling;molecular subtypes;Mus;Mutate;novel strategies;novel therapeutics;Pathogenesis;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;PIK3CG gene;Pre-Clinical Model;Process;promoter;Proteins;Proto-Oncogene Proteins c-akt;Regulation;Relapse;Reporting;Research Design;Research Proposals;Sampling;Series;Signal Pathway;Signal Transduction;Sirolimus;small molecule inhibitor;success;Therapeutic;Transcriptional Regulation;Translations;United States;United States National Institutes of Health;Veterans;Work;Xenograft Model

PROJECT_TITLE: Pathologic Signaling Pathways in AML Cells


ORG_CITY: TAMPA

ORG_NAME: JAMES A. HALEY VA MEDICAL CENTER

ORG_STATE: FL

PHR: It is estimated that 14% of the general population in the US live with chronic kidney disease (CKD); however, the prevalence of CKD in veterans is 34% higher compared to the general population. One of the main challenges in CKD is impaired phosphate homeostasis. Given the considerable negative sequelae associated with hyperphosphatemia, such as increased cardiovascular mortality, reducing plasma phosphate is a critical goal of therapy. Renal phosphate reabsorption is mediated by the sodium- phosphate cotransporters Npt2a and Npt2c. The former mediates the majority of renal phosphate reabsorption (~75%). We identified that pharmacological inhibition of Npt2a, via a novel orally absorbable Npt2a inhibitor, causes phosphaturia, reductions in plasma phosphate levels and suppression of parathyroid hormone, but also increases urinary excretion of sodium and chloride. Our studies will provide critical insight if Npt2a inhibition will improve phosphate homeostasis and hypertension in CKD.

PI_NAMEs: RIEG, TIMO  (contact)

PROJECT_TERMS: absorption;Address;Adenine;Affect;Animals;apical membrane;Biochemistry;Biological Availability;Biological Process;blood pressure reduction;bone;Calcium;Cardiac;cardiovascular risk factor;Cardiovascular system;Carrier Proteins;Chlorides;Chronic;Chronic Kidney Failure;Clinical;clinical application;clinically relevant;Confocal Microscopy;Data;Diet;dietary;Disease;Dose;Electrolytes;Energy Metabolism;Equilibrium;Excretory function;Exhibits;experimental study;Failure;feeding;fibroblast growth factor 23;General Population;Genetic;Glomerular Filtration Rate;Goals;Homeostasis;Hormonal;Hormones;Hour;Hyperparathyroidism;Hypertension;Impairment;improved;in vivo;inhibitor;inorganic phosphate;Inorganic Phosphate Transporter;insight;Intake;Intestines;Kidney;Kidney Calculi;Knockout Mice;Mediating;Minerals;Modeling;Morphology;mortality;mouse model;Nephrectomy;novel;Nutrient;Oral;Pathology;Patients;PF4 Gene;Pharmacodynamics;pharmacologic;Physiological;Plasma;Play;Potassium;Prevalence;Process;Protein Biosynthesis;PTH gene;Quality of life;Regulation;Renal function;Role;Secondary Hyperparathyroidism;Signal Transduction;Skeletal bone;Skeletal Development;Sodium;sodium-phosphate cotransporter proteins;Specificity;symporter;Therapeutic;Time;uptake;urinary;Veterans;Wild Type Mouse

PROJECT_TITLE: Pharmacological Npt2a inhibition as a treatment for hyperphosphatemia in chronic kidney disease


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Data Science;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Stomach Cancer

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: Gastric cancer is a devastating disease with poor prognosis. The risk for gastric cancer in the general population of the United States is low; however, certain ethnic, racial, and immigrant groups are at much higher risk. There is a need for better tools to identify these high-risk individuals in order to improve outcomes from gastric cancer.

PI_NAMEs: HUANG, ROBERT JEFFREY (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Achievement;Address;advanced analytics;Age;Alaska Native;American Indians;Asian population;Attention;attenuation;Black Populations;Board Certification;Calibration;cancer diagnosis;cancer health disparity;cancer risk;career development;Characteristics;Clinical;Clinical Data;Clinical Informatics;clinically actionable;cohort;Collection;Communication;Data;Data Analytics;data mining;Data Science;Data Set;Data Sources;data streams;deep learning;Development;Development Plans;Diagnosis;Discrimination;Disease;disparity elimination;disparity reduction;Electronic Health Record;Ensure;Environment;Epidemiologist;Epidemiology;Equity;Ethnic Origin;Ethnic Population;Excision;experience;Face;Funding;gastric cancer prevention;Gastroenterologist;General Population;Goals;Grant;health care disparity;Health Disparities Research;health equity;Health Services Research;Healthcare;Helicobacter pylori;high risk;high risk population;Hispanic Populations;Immigrant;improved;improved outcome;Individual;Inequity;Informatics;Information Retrieval;Inpatients;Institution;Laboratories;Lasso;Leadership;learning algorithm;Machine Learning;machine learning algorithm;machine learning model;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;malignant stomach neoplasm;Master of Science;Measures;Medicare;Mentors;Mentorship;Methodology;Modeling;Morbidity - disease rate;mortality;multi-ethnic;National Cancer Institute;Natural Language Processing;Nature;Neighborhoods;neural network;Not Hispanic or Latino;novel;Observational Study;Outcome;outcome prediction;Outpatients;Performance;personalized predictions;personalized risk prediction;Pharmacy facility;Phenotype;Poverty;Precision Health;Prevention;Probability;Prognosis;programs;Race;racial diversity;random forest;Reporting;Research;Research Design;Research Personnel;Risk;Risk Factors;risk prediction;risk prediction model;Screening for Gastric Cancer;sex;skills;Smoking;Subgroup;success;supervised learning;support vector machine;System;Techniques;Testing;Time;tool;Training;Unemployment;United States;Universities;unstructured data;Validation;Work;years of life lost

PROJECT_TITLE: PRECISE - a PErsonalized Risk Score for gastrIc CancEr

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Patient Safety;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: PSYCHIATRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: In response to RFA-DA-19-018, we propose to maintain and enhance the established medication development infrastructure at Virginia Commonwealth University Institute for Drug and Alcohol Studies (IDAS) to support Phase I and Phase 2 clinical trials in collaboration with the Division of Therapeutics and Medical Consequences at NIDA. As a demonstration project of the ability of IDAS to conduct early phase clinical trials, we propose to assess safety, target engagement, and preliminary measures of efficacy, for the serotonin 2C receptor agonist lorcaserin in combination with buprenorphine for opioid use disorder.

PI_NAMEs: ARIAS, ALBERT JOSEPH;MOELLER, FREDERICK GERARD (contact)

PROGRAM_OFFICER_NAME: AKLIN, WILL

PROJECT_TERMS: abuse liability;Adverse event;Agonist;Alcohols;Amygdaloid structure;analog;Anti-Anxiety Agents;Anticonvulsants;Anxiety;anxiety symptoms;Behavioral;Benefits and Risks;Brain;Brain imaging;Buprenorphine;Clinical;clinical development;Clinical Research;Cocaine;cocaine cue;Cocaine use disorder;Collaborations;comorbidity;craving;cue reactivity;Cues;Data;Development;Development Plans;Dose;Double-Blind Method;Dropout;drug craving;Drug Interactions;early phase clinical trial;Emotional;experimental study;Face;Frequencies;Functional Magnetic Resonance Imaging;functional MRI scan;Funding;Future;gamma-Aminobutyric Acid;Grant;Hippocampus;Hour;Human;Hypothalamic structure;imaging study;improved;Impulsivity;infrastructure development;Inpatients;Institutional Review Boards;Laboratories;Magnetic Resonance Imaging;Measures;Medical;Naloxone;naloxone dosing;National Institute of Drug Abuse;neural circuit;neuroimaging;novel;Opioid;opioid use disorder;opioid withdrawal;Outpatients;Participant;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phase II Clinical Trials;Phenotype;placebo controlled study;Placebos;Plasma;pre-clinical;Pre-Clinical Model;Pulse Oximetry;Randomized;Research;research clinical testing;Research Design;Resources;response;Rodent;Safety;safety assessment;safety study;Sample Size;Sampling Studies;Scanning;Self Administration;Serious Adverse Event;Serotonin Receptor 5-HT2C;side effect;Signal Transduction;Spectrum Analysis;Stress;stress reactivity;Suboxone;Substance Use Disorder;Technology;Therapeutic;Treatment Protocols;Universities;Virginia;Visual;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Laboratories for Early Clinical Evaluation of Pharmacotherapies for Substance Use Disorders


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The Lineberger Comprehensive Cancer Center (LCCC) forms the nexus for researchers focused on understanding and identifying the mechanisms leading to, the prevention of, and treatments for cancer. LCCC is an integral component of the research mission at The University of North Carolina (UNC) at Chapel Hill, coalescing the cancer research capabilities of the Schools of Medicine, Public Health, Pharmacy, and Nursing, and the College of Arts and Sciences. The LCCC strives to reduce cancer incidence, morbidity, and mortality in North Carolina, the United States and across the globe through innovative research, cutting-edge treatments, multi-disciplinary training, education and outreach.

PI_NAMEs: EARP, H. SHELTON (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: anti-cancer research;Appointment;Arts;authority;Award;Basic Cancer Research;Basic Science;Behavioral;Bioinformatics;Biology;Budgets;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer epidemiology;cancer genetics;cancer research center director;cancer therapy;career;Caregivers;Caring;Catchment Area;Chemicals;chimeric antigen receptor T cells;Clinic;Clinical Data;Clinical Protocols;Clinical Research;Clinical Sciences;Clinical Trials;college;Communication;Communities;community based participatory research;community college;community engagement;Community Outreach;Comprehensive Cancer Center;Consultations;Data;data management;Development;Direct Costs;Discipline of Nursing;Disease;Disparity;drug discovery;Early Diagnosis;Education and Outreach;Epidemiology;epidemiology study;Epigenetic Process;Evaluation Research;Facility Construction;Faculty;Fostering;Funding;Future;Genetic Research;Genomic approach;Government;Grant;Health;Health Resources;Health Services;Healthcare;Human;imaging detection;Incidence;Information Systems;Infrastructure;innovation;Institution;Insurance Carriers;Intervention;Intervention Trial;Investments;Leadership;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Medicaid;medical schools;Medicare;member;minority disparity;Minority Groups;Mission;Molecular Epidemiology;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Names;neoplasm registry;North Carolina;Oncology;operation;Outcome;outreach;Patient Care;Patients;Performance;Pharmacologic Substance;Pharmacy facility;Policies;Population;population based;population health;Population Heterogeneity;Population Sciences;Prevention;Privatization;Productivity;programs;Protocols documentation;Public Health;public policy on tobacco;Publications;Publishing;recruit;Research;Research Personnel;Resource Sharing;Resources;Role;Rural Population;safety net;Schools;Science;Scientist;screening services;senior faculty;Services;Stretching;survivorship;System;Talents;Technology;The Cancer Genome Atlas;Therapeutic;Training;Training and Education;Translating;Translations;undergraduate student;United States;Universities;Urban Population

PROJECT_TITLE: Cancer Center Support Grant


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: anti-cancer research;Area;Award;Basic Science;Budgets;Cancer Center;Cancer Center Support Grant;cancer education;career;Catchment Area;Clinical Sciences;Committee Membership;Communication;Communities;community advisory board;community engagement;Community Outreach;Comprehensive Cancer Center;computer network;Contracts;Development;Education;Ensure;Equipment;Evaluation;experience;Faculty;Fostering;Funding;Funding Opportunities;Grant;Human Resources;Informatics;Information Technology;Infrastructure;innovation;Institution;Leadership;Malignant Neoplasms;meetings;member;Mentors;Mission;Monitor;NCI Center for Cancer Research;North Carolina;operation;Output;Patient advocacy;Population Sciences;Process;programs;Recommendation;recruit;Recurrence;Reporting;Research;Research Activity;Resource Sharing;Resources;Services;Strategic Planning;Surveys;symposium;Training;Training and Education;translational cancer research;Translational Research;UNC Lineberger Comprehensive Cancer Center;United States National Institutes of Health;Universities;Vision;Wages;Work

PROJECT_TITLE: Admin-Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: CORVALLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: Narrative for Genetic Code Expansion Center The Genetic Code Expansion Biomedical Technology Development and Dissemination Center will allow biomedical researchers around the world to have access to better scientific tools to generate specially designed forms of proteins for probing and visualizing how life works. This will help them better determine how and where biological processes go wrong to cause cancer, heart disease, pain, diabetes, Parkinson's disease, and many other diseases, and will also drive new innovations and enable the development of more sensitive and specific diagnostic tests and more effective drugs.

PI_NAMEs: MEHL, RYAN A (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Adopted;Amino Acids;analog;Automobile Driving;Awareness;Basic Science;Beds;Biochemical;Biological;Biological Process;Biological Response Modifier Therapy;Biomedical Research;Biomedical Technology;Biophysics;Cancer Etiology;Cardiovascular Diseases;Cations;Cell Line;Cells;cellular engineering;Cellular Structures;Chemicals;Collaborations;Communities;community engagement;Community Networks;design;Development;Diabetes Mellitus;Diagnostic;Diagnostic tests;Disease;Education;Educational workshop;Engineering;Ensure;Escherichia coli;Evolution;experience;Foundations;functional group;Funding;Genetic Code;Genetic Transformation;Geography;Goals;Heart Diseases;improved;Inflammation;innovation;interest;International;Knowledge;knowledgebase;Label;Leadership;Life;life span;Ligation;Malignant Neoplasms;Mammalian Cell;Methods;Mission;Molecular;Molecular Structure;Nerve Degeneration;Oregon;Pain;Parkinson Disease;Pathogenesis;peer;peer support;Pharmaceutical Preparations;Phosphorylation;Physiological;Post-Translational Protein Processing;Process;Production;Productivity;programs;Property;Protein Dynamics;protein function;protein structure;Proteins;Protocols documentation;public repository;Reaction;Reagent;Regulation;repository;Reproducibility;Research;Research Personnel;Site;Specialist;Speed;symposium;synergism;System;Technology;technology development;Testing;Tetanus Helper Peptide;Therapeutic;tool;Training;Training Activity;Translations;United States National Institutes of Health;Universities;Visualization;web site;wiki;Work

PROJECT_TITLE: The GCE4All Center: Unleashing the Potential of Genetic Code Expansion for Biomedical Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(55)R]


ORG_CITY: CHICAGO

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

ORG_STATE: IL

PHR: Loss of muscle mass occurs in many diseases or as a consequence of aging. It is associated with loss of independence, risk for illness, as well as death, and it may disproportionately affect veterans compared to the general population because of their age and disabling medical conditions from military service. Aside from exercise, there are no current therapies. In this project, we elucidate a gene switch controlling muscle mass. Insights from these studies may identify a therapeutic pathway to halt or reverse muscle loss.

PI_NAMEs: BARISH, GRANT D (contact)

PROJECT_TERMS: acute infection;Affect;Age;Aging;American;Atrophic;Autophagocytosis;BCL6 gene;Binding Sites;Biochemical;Bioinformatics;Biological Assay;Body Composition;Caloric Restriction;Cessation of life;ChIP-seq;chronic infection;Complex;Data;Deuterium;Diabetes Mellitus;disability;Disabling;Disease;Enhancers;epigenomics;Eukaryotic Initiation Factor-4E;Exercise;Fasting;FRAP1 gene;gain of function;gene regulatory network;General Population;Genes;Genetic Engineering;Genetic Markers;genome-wide;Hand Strength;Health Care Costs;Heart failure;Histone Acetylation;histone modification;Histones;Homeostasis;human old age (65+);in vivo;inhibitor;Injury;insight;Isometric Exercise;Kidney Failure;Kinetics;Knockout Mice;Label;Link;loss of function;Lysine;Malignant Neoplasms;Malnutrition;Measures;Medical;Metabolism;military service;Molecular;Morbidity - disease rate;mortality;Mus;Muscle;Muscle Cells;muscle form;Muscle Proteins;Muscular Atrophy;Myosin ATPase;Nucleic Acid Regulatory Sequences;nutrition;overexpression;Pathway interactions;Performance;Pharmaceutical Preparations;Physiological;Play;Polyribosomes;posttranscriptional;Prevalence;prevent;Prevention;promoter;Protein Biosynthesis;protein degradation;Protein Isoforms;Proteins;proteostasis;Puromycin;Regulation;Repression;response;Risk;Role;sarcopenia;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;Somatotropin;Source;Specific qualifier value;Spirometry;Stains;Switch Genes;Testing;Therapeutic;Tissues;Transcription Repressor;Transcriptional Regulation;transcriptome sequencing;transgene expression;Translation Initiation;Translations;Tyrosine;Veterans

PROJECT_TITLE: Transcriptional Control of Skeletal Muscle Atrophy


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This new application requests funding to support an Initiative for Maximizing Student Development (IMSD) T32 at Emory University that will support graduate students from groups historically excluded and underrepresented in biomedical science at an early stage of graduate training to position them for success. We propose activities to support graduate training by building scientific identity and resilience while embracing research excellence through an engaged, supportive, and diverse IMSD community. Training activities, which will complement but not duplicate, discipline-specific requirements will: include evidence-based learning approaches, train students in scientific writing through a formal course, ensure training in rigor and reproducibility, mandate mentor training for all faculty mentors, build mentoring and professional networks, and emphasize career/professional development with the goal of contributing to student success and a diverse biomedical research workforce.

PI_NAMEs: CORBETT, ANITA H. (contact);FAUNDEZ, VICTOR ;JAMES, AMANDA MARIE;SUGLIA, SHAKIRA FRANCO

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Universities

PROJECT_TITLE: IMSD at Emory University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ORG_CITY: PROVIDENCE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative This program addresses an important societal need to increase the number of individuals from underrepresented backgrounds who enter and complete doctoral training in the biomedical and behavioral sciences. We propose to accomplish this goal through exposure to cutting-edge research experiences, broad mentorship support, and targeted educational and professional development activities that prepare students to succeed in Ph.D. or MD- PhD programs and enhance diversity in the Biomedical Research Workforce.

PI_NAMEs: AIZENMAN, CARLOS D (contact);JAMIESON, AMANDA M;MOSLEY AUSTIN, ALYCIA

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;aluminum sulfate;Behavioral Sciences;Biological Sciences;Biology;Biomedical Research;Caliber;career;career development;career networking;Cognitive;Communication;Communities;community building;Critical Thinking;Degree program;design;Development;Development Plans;disadvantaged background;Diverse Workforce;Doctor of Philosophy;Doctor's Degree;Education;education research;Educational Status;Enrollment;Ensure;Environment;Evaluation;experience;Exposure to;Faculty;faculty mentor;Fostering;Funding;Goals;graduate school;graduate student;health disparity;Historically Black Colleges and Universities;Immunology;improved;Individual;innovation;Institutionalization;Interdisciplinary Study;Intervention;Knowledge;Leadership;Learning;Life;Linguistics;Link;Literature;matriculation;Measurable;Medical;meetings;Mentors;Mentorship;Microbiology;Minority-Serving Institution;Molecular;Monitor;Names;Neurosciences;Oral;Outcome;Outcome Assessment;Participant;peer coaching;Postbaccalaureate;Preparation;Production;programs;psychologic;Public Health;Qualifying;quality assurance;Readiness;recruit;Research;Scholars Program;Science;Series;skill acquisition;skills;Solid;STEM career;Structure;Students;success;supportive environment;Training;Training and Education;Training Programs;undergraduate research experience;Underrepresented Students;Universities;Work;Writing

PROJECT_TITLE: Brown University Postbaccalaureate Research Education Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Cancer;Pediatric

PI_NAMEs: YEH, JEN JEN  (contact)

PROJECT_TERMS: Address;Administrator;anti-cancer research;Applications Grants;Area;Award;base;Basic Science;Biomedical Research;boys;cancer care;Cancer Center;Cancer Center Support Grant;cancer education;cancer genetics;Cancer Research Project;career;career development;Catchment Area;clinical care;Clinical Research;Clinical Sciences;Collaborations;college;Communities;community college;Community Health Education;Community Outreach;Competence;Complex;Comprehensive Cancer Center;Continuing Education;County;Coupled;design;Development;Direct Costs;Discipline;Doctor of Philosophy;Education;Education and Outreach;Education Projects;Educational Activities;Epigenetic Process;Evaluation;Event;experience;Faculty;Feedback;Fellowship;Fellowship Program;fluidity;Funding;girls;graduate school;Growth;Healthcare;high school;Historically Black Colleges and Universities;improved;Individual;Infrastructure;innovation;interest;Knowledge;Leadership;Malignant Neoplasms;Mathematics;medical schools;Medicine;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methods;minority disparity;Mission;multidisciplinary;NCI Center for Cancer Research;Needs Assessment;neoplasm resource;next generation;North Carolina;Oncology Nurse;oncology program;Oranges;Outcome;Physicians;Population Sciences;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Program Development;programs;Recording of previous events;recruit;Research;Research Personnel;Research Support;Research Training;Resource Sharing;Resources;Role;Schools;Science;Scientist;senior faculty;Students;success;Surgical Oncology;System;Teacher Professional Development;Technology;Tissues;Training;Training and Education;training opportunity;Training Programs;translational oncology;Translational Research;UNC Lineberger Comprehensive Cancer Center;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Universities;university student;Work;Workforce Development

PROJECT_TITLE: Cancer Research Career Enhancement and Related Activities


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: TALLAHASSEE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: Program Director/Principal Investigator (Last, First, Middle): Ralston, Penny A. Project Narrative African Americans have higher heart disease and stroke-related morbidity and mortality in comparison to Non- Hispanic Whites and other ethnic/racial groups. Church-based health interventions have shown improvement in health behaviors and clinical outcomes, yet there is limited research available that evaluates the extent to which churches themselves can implement these interventions. This proposed project will determine the effectiveness of HHUC implementation strategies in relation to process outcomes and reducing CVD risk in African Americans, examining two possible strategies. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: RALSTON, PENNY ANN (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TERMS: acceptability and feasibility;Adoption;Affect;African American population;Area;Cardiac health;Cardiovascular Diseases;cardiovascular disorder risk;Cause of Death;Church;Clinical;Collaborations;collaborative environment;Communities;community academic partnership;community based participatory research;comparison group;Consolidated Framework for Implementation Research;cost;County;Data;design;Diastolic blood pressure;dietary;Effectiveness;effectiveness evaluation;effectiveness/implementation hybrid;Ethnic Origin;Event;evidence base;Florida;Food;Health;Health behavior;Heart Diseases;implementation intervention;implementation strategy;improved;Individual;Intervention;Intervention Studies;leadership development;Life Style;Maintenance;Modeling;Morbidity - disease rate;mortality;Not Hispanic or Latino;Outcome;Participant;Phase;Physical activity;physical conditioning;Pilot Projects;Principal Investigator;Process;programs;racial population;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Risk Factors;Science;Stroke;Structure;success;successful intervention;Testing;theories;treatment group;United States;Work

PROJECT_TITLE: The Health for Hearts United Collaborative

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: DOYLESTOWN

ORG_NAME: BARUCH S. BLUMBERG INSTITUTE

PHR: Hepatocellular carcinoma (HCC) is the world’s 2nd leading cause of cancer-related death and one of the fastest-growing cancers in the US; 85% of patients die within 5 years, mainly due to late detection, limited treatment options, and high recurrence. This project is to develop a robust evidence-based urine biospecimen practice for sample collection, processing, and long-term storage will lead to the validation of urine tests for assessing HCC treatment in clinical trials.

PI_NAMEs: SU, YING-HSIU  (contact)

PROGRAM_OFFICER_NAME: GUAN, PING

PROJECT_TERMS: AFP gene;Aftercare;Apoptotic;assay development;Biological Assay;Blood;Cancer Etiology;cancer type;Cells;Centrifugation;Cessation of life;Chronic Hepatitis B;Clinic;Clinical;Clinical Data;Clinical Trials;Collection;Colon Carcinoma;Detection;detection sensitivity;diagnosis standard;DNA;DNA analysis;DNA Maintenance;DNA Markers;Early Detection Research Network;Early Diagnosis;Edetic Acid;Enrollment;evidence base;Excision;Freezing;Genetic;genetic profiling;Genomic DNA;Genomics;Goals;Guidelines;Hepatitis B Infection;Hepatitis B Virus;Hepatocyte;Home;Hour;Image;Intake;Kidney;liquid biopsy;Liquid substance;Literature;Liver;Magnetic Resonance Imaging;Malignant Neoplasms;Measurement;Methods;Molecular Weight;Monitor;National Comprehensive Cancer Network;Nodule;Patients;Performance;preservation;Primary carcinoma of the liver cells;Procedures;Process;Prognosis;prospective;Prospective Studies;Protocols documentation;radiological imaging;Recommendation;Recovery;Recurrence;Reproducibility;response;sample collection;Sampling;serial imaging;Serum;Site;standard of care;Temperature;Testing;Time;treatment response;tumor;tumor DNA;tumor progression;Urine;Validation;validation studies;viral DNA;X-Ray Computed Tomography

PROJECT_TITLE: Impact of preanalytic procurement and processing variables on the detection of HCC DNA in urine


NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: MOBILE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA

ORG_STATE: AL

PHR: PROJECT NARRATIVE Acidosis is common in critically ill pneumonia patients and is associated with high mortality. Carbonic anhydrase IX (CA IX) is a critical determinant of pulmonary microvascular endothelial cell (PMVEC) acid regulation, metabolism and migration, and Pseudomonas aeruginosa infection induces cytotoxic amyloid production that induces soluble CA IX shedding from PMVECs. In this project, we test the hypothesis that Pseudomonas aeruginosa induces production of cytotoxic amyloids which leads to CA IX shedding from PMVECs that increases lung injury, with the goal of identifying biomarkers and therapeutic targets for pneumonia.

PI_NAMEs: LEE, JI YOUNG  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acidosis;Acids;Affect;Alveolar;Amyloid;Amyloid Proteins;Antibiotics;Bacteria;base;Bicarbonates;Biological Assay;Biological Markers;biomarker identification;Blood;Blood capillaries;Bronchoalveolar Lavage Fluid;Buffers;Carbon Dioxide;carbonate dehydratase;Cardiogenic Shock;Catalytic Domain;cell motility;Cells;Cellular Metabolic Process;Chronic;Circulation;Cleaved cell;Critical Illness;cytotoxic;cytotoxicity;Data;Death Rate;Diagnostic;Endothelial Cells;Endothelium;Enzymes;Family;Functional disorder;Gases;genetic approach;Goals;hexokinase;Human;Impairment;improved;In Vitro;in vivo;Infection;injury and repair;insight;Intensive Care Units;Length;long-term sequelae;Lung;lung injury;lung microvascular endothelial cells;Mediating;Membrane;Metabolic acidosis;Metabolism;migration;mortality;mouse model;Organ;Outcome;Patients;Perfusion;Phosphorylation;Physiological;Pneumonia;preservation;Production;protein expression;Protein Isoforms;Proteoglycan;Protons;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;pyruvate dehydrogenase;Rattus;Regulation;repaired;Reporting;Research;Resistance;Role;Sampling;System;Testing;therapeutic target;Tissues;Toxic effect;Translating;translational therapeutics;Transmembrane Domain;Water

PROJECT_TITLE: Acidosis in pulmonary endothelial injury and repair

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative DNA damage caused by environmental genotoxicants will result in mutations and disease if not repaired rapidly and accurately. Homology directed repair (HDR) is an essential mechanism of faithful DNA repair, but our understanding of it is limited because prior studies have largely used models of embryonic development, cell culture, or cancer. We have developed a model of Brca1/HDR deficiency in adult mice to determine how HDR preserves viability and maintains genome integrity in various tissues after exposure to different types of DNA damage.

PI_NAMEs: JACKSON, JAMES  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Address;Adult;Age;Animal Model;Apoptosis;biological adaptation to stress;Biological Models;brca gene;BRCA1 gene;Cell Culture Techniques;Cell Cycle Arrest;Cell Survival;Cells;Classification;Code;crosslink;Data;deep sequencing;Dependence;Development;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;Double Strand Break Repair;Embryo;Embryonic Development;environmental mutagens;exome;Exposure to;Failure;Gene Expression;gene repair;Genes;Genetic Transcription;Genetically Engineered Mouse;Genome;genome integrity;Genomics;Genotoxic Stress;Germ Lines;Health;Human;human tissue;in vivo;Individual;irradiation;Knock-out;Ligase;Link;Longevity;Maintenance;Malignant Neoplasms;Mammals;Mammary gland;Measures;Mediating;Mediator;Messenger RNA;Mitomycin C;Modeling;mouse model;Mus;Mutagenesis;Mutation;Mutation Analysis;Nonhomologous DNA End Joining;Normal tissue morphology;Organ;Organism;Pathology;Pathway interactions;Phenotype;preservation;prevent;programs;repair function;repaired;Research;response;Role;senescence;Somatic Mutation;Stress;Tissues;TP53 gene;transcription factor;transcriptomics;tumor;Vertebrates

PROJECT_TITLE: Genotoxic stress response and mutagenesis in normal tissues of mice deficient in homology directed repair

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


PI_NAMEs: BEAR, JAMES E (contact)

PROJECT_TERMS: Actins;Address;angiogenesis;anti-cancer research;Apoptosis;Area;Basic Science;Biochemistry;Biology;Biophysics;Blood Vessels;cancer cell;Cancer Center Support Grant;Cancer Intervention;cancer therapy;career;Catchment Area;Cell Cycle;Cell Cycle Regulation;cell motility;Cell Physiology;Cells;Cellular biology;Chromatin;Clinical;Clinical Sciences;Clinical Trials;Collaborations;commercialization;Communities;community engagement;Community Outreach;Complex;Core Facility;Cullin Proteins;Cytoskeleton;Development;Dioxygenases;Direct Costs;Disparity;DNA;DNA biosynthesis;DNA Modification Process;DNA Repair;Doctor of Philosophy;drug discovery;Education;Educational process of instructing;effective therapy;Electronic cigarette;Entrepreneurship;Environment;Enzymes;Epigenetic Process;Equipment;Event;Extramural Activities;Faculty;Faculty Recruitment;Family;Fostering;Funding;Genomics;Goals;Grant;Growth Factor;high school;histone modification;improved;insight;Institution;interest;Intervention;Investments;Joints;junior high school;Knowledge;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;meetings;Melanoma;member;Mentors;Mentorship;Metabolism;migration;Modeling;Molecular;Motility;Multiple Myeloma;Neoplasm Metastasis;neoplastic cell;new therapeutic target;North Carolina;novel diagnostics;novel therapeutics;Output;Pancreas;Pathway interactions;peer;Phase;Phenotype;Pilot Projects;Population;Population Sciences;pre-clinical;preclinical trial;Productivity;professor;Program Development;programs;Prostate;Publishing;receptor;Recording of previous events;Regulation;Research;Research Activity;research and development;Research Personnel;Resistance;Resource Sharing;response;RNA;Role;Scientist;Seminal;Signal Pathway;Signal Transduction;small molecule inhibitor;Structure;symposium;Talents;targeted cancer therapy;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;Training;Transcriptional Regulation;Translating;Translations;tumor;Tumor Cell Invasion;tumor initiation;tumor progression;Tumor Suppression;tumorigenesis;Ubiquitin;ubiquitin-protein ligase

PROJECT_TITLE: Cancer Cell Biology Research Program


NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Vector-Borne Diseases

ORG_CITY: DALLAS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: These studies are pertinent to public health since they aim to understand the roles for stem cells in the human pathogen Schistosoma mansoni. Completion of the proposed research could aid in the discovery of new drugs to combat disease caused by this important human parasite.

PI_NAMEs: COLLINS, JAMES J (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Address;Adolescent;Adult;adult stem cell;Atlases;Behavior;Biology;Blood;Cells;Chronic;combat;Communities;Data;Development;Disease;Dose;egg;Environment;Failure;fascinate;Flow Cytometry;Funding;Gene Expression;Genes;Growth;Human;human pathogen;in vivo;Injury;Malaria;Mechanics;Mediating;Modeling;Modernization;Molecular;Molecular Analysis;Muscle;Natural regeneration;new therapeutic target;novel;novel therapeutics;Outcome;Output;Parasites;Parasitic Diseases;pathogen;Pathology;Pharmaceutical Preparations;Planarians;Platyhelminths;Play;Population;Praziquantel;Process;programs;Proliferating;Public Health;Refractory;regenerative;Regenerative capacity;Regenerative response;repaired;Research;Resources;response to injury;Role;Schistosoma;Schistosoma mansoni;Schistosomiasis;single-cell RNA sequencing;Site;Skin;Specific qualifier value;stem cell biology;stem cells;Testing;tissue regeneration;tissue repair;Tissues;tool;wound

PROJECT_TITLE: The Biology of Stem Cells in the Human Parasite Schistosoma Mansoni

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Certain diseases of the central nervous system are caused by cells of the immune system that attack neurons. It is thought that these immune cells originate from the blood and infiltrate the brain. In this grant, we propose to test the hypothesis that the bone marrow of the skull is actually the major source of some of these immune cells, which infiltrate the nervous system through the meninges, reside there and eventually develop into autoreactive cells that cause disease.

PI_NAMEs: COLONNA, MARCO  (contact);PERNIS, ALESSANDRA B

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Ablation;age related;Aging;Antigens;Applications Grants;Arachnoid mater;Autoantigens;Autoimmune Diseases;Autoimmune Diseases of the Nervous System;Autoimmune Responses;Autoimmunity;autoreactive B cell;autoreactivity;B cell repertoire;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Behavioral;Bioinformatics;Blood;Blood Vessels;bone;Bone Marrow;Bone Marrow Transplantation;Brain;Calvaria;Cell Compartmentation;cell motility;Cell Separation;Cells;Central Nervous System;Central Nervous System Diseases;Cephalic;Cerebrospinal Fluid;Circulation;Clone Cells;CNS autoimmunity;confocal imaging;cranium;Data;Development;Disabling;Disease;Dura Mater;Environment;experience;experimental study;Fibroblasts;flat bone;follow-up;Gene Expression;Gene Expression Profile;Goals;Grant;Hematopoietic;Homeostasis;Homing;Human;human model;Immune;Immune system;Immune Tolerance;Immunoglobulins;Immunologic Surveillance;Infiltration;Invaded;Knock-out;Knockout Mice;Knowledge;Light;Lupus;lupus-like;Lymphocyte;Lymphocytic Infiltrate;lymphoid organ;Mature B-Lymphocyte;Mediating;Membrane;Meningeal;Meninges;Minor;Modeling;Monoclonal Antibodies;mouse model;MS4A1 gene;Multiple Sclerosis;Mus;Nervous System;neuroinflammation;Neurons;Neuropsychiatric Systemic Lupus Erythematosus;old mice;Parabiosis;Pathogenicity;Pathology;Periosteum;Peripheral;Plasma Cells;Plasmablast;Play;preservation;Publishing;Reactive Plasma Cell;reconstitution;recruit;response;rituximab;Role;Science;Seminal;Source;Specificity;Specimen;Spinal Cord;Spleen;Stromal Cell-Derived Factor 1;Subarachnoid Space;Surface;Syndrome;Systemic Lupus Erythematosus;Techniques;Testing;theories;Tissues;transcriptomics;Treatment Efficacy;Update;Work;young adult

PROJECT_TITLE: Ontogenetic niche of B cells at the CNS borders in homeostasis, aging and autoimmunity

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Liver Disease;Organ Transplantation;Transplantation

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT There are currently over 110,000 patients on the organ transplant waiting list in the US, a number that far exceeds the supply of available organs. A major reason is the limitations of our current organ preservation technology, which disallows the transplantation of marginally injured organs and limits preservation duration. This project aims to improve public health by developing a protocol to bank organs for several weeks up to a few months, enabling global organ matching and potentially utilization of organs unusable with current technology.

PI_NAMEs: TONER, MEHMET  (contact);UYGUN, KORKUT ;YARMUSH, MARTIN L

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Address;Animals;animation;Antioxidants;Bacteria;Bioenergetics;Blood Vessels;cell injury;Cell Survival;Cells;Cellular Morphology;Charge;Chimerism;Circulation;Citric Acid Cycle;cold temperature;cost;Crystallization;Data;Endothelial Cells;Endothelium;Engineering;Exhibits;experience;extracellular;Extracellular Space;Fatty Acids;Freezing;Funding;Glutathione;Hour;Human;Ice;improved;inhibitor;Injury;innovation;ischemic injury;Legal patent;Length;Liver;liver preservation;liver transplantation;Location;Measures;Metabolic;metabolomics;Methods;Microscopic;Modeling;Molecular;Movement;natural hypothermia;Nature;Operative Surgical Procedures;Organ;Organ Donor;organ injury;Organ Preservation;Organ Transplantation;oxidation;Oxygen;Patients;Perfusion;Permeability;point of injury;preconditioning;preservation;prevent;programs;Protocols documentation;Public Health;public health relevance;Rana;Rattus;Recovery;Reperfusion Injury;Research;Rodent;scale up;shear stress;Signal Transduction;success;System;Technology;Temperature;Time;Tissue Engineering;Tissues;Toxic effect;transcriptome sequencing;Transplantation;Trehalose;Vascular Endothelium;vascular injury;Vascular resistance;Viscosity;Waiting Lists;wasting;Wood material

PROJECT_TITLE: High subzero preservation of liver for transplantation

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Traumatic brain injury (TBI) is a common cause of morbidity in the veteran population. According to the NIH Consensus Development Panel on Rehabilitation of Persons with TBI, an estimated 2.5-6.5 million Americans live with TBI-related disabilities. The long term consequences of TBI may extend beyond the associated neuro- cognitive deficits as recent studies have indicated that the risk of cardiovascular mortality is markedly increased in subjects with a history of TBI. This mortality risk is associated with increased plaque build-up in the arteries suggesting that TBI promotes atherosclerosis. However, the causal relationship between TBI and vascular disease is not clear. If there is a causal relationship between TBI and vascular disease, this will have immediate implications for preventive therapies. The goal of this proposal is to validate the causal relationship and mechanisms involved in vascular disease associated with TBI. Potential therapies will also be tested. Results of these studies may lead to novel strategies to reduce vascular events in subjects with TBI.

PI_NAMEs: EITZMAN, DANIEL T (contact)

PROJECT_TERMS: Acceleration;Adhesives;Adrenergic Agents;Adrenergic Antagonists;Adrenergic Receptor;American;Apolipoprotein E;Arrhythmia;Arterial Fatty Streak;arterial stiffness;Arteries;atherogenesis;Atherosclerosis;Biological Markers;Blood Vessels;Bone Marrow;Bone Marrow Cells;Brain Injuries;Cardiac;Cardiomyopathies;cardiovascular effects;cardiovascular risk factor;Cardiovascular system;Catecholamines;Cerebrovascular Disorders;Chronic;Clinical Research;Consensus Development;Control Groups;coronary artery calcification;cytokine;Cytokine Receptors;Data;design;Development;disability;Disease;Electrocardiogram;Electron Beam Tomography;endothelial dysfunction;Endothelium;Enzyme-Linked Immunosorbent Assay;Etiology;Event;extracellular;Flow Cytometry;Goals;Histologic;Hyperactivity;in vitro Assay;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Interleukin-1 Receptors;Leukocytes;Ligands;Link;Liquid Chromatography;Magnetic Resonance Imaging;Measures;Mediating;Mediator;Methods;military veteran;Morbidity - disease rate;mortality;mortality risk;mouse model;Mus;Myelogenous;Myeloid Cells;Myocardial Infarction;Neurocognitive Deficit;neutrophil;novel strategies;P-selectin ligand protein;Pathway interactions;Persons;prevent;Preventive therapy;Process;Reactive Oxygen Species;Receptor Inhibition;Receptor Signaling;Recording of previous events;Rehabilitation therapy;Relative Risks;Research;Risk;Role;Severities;Signal Transduction;specific biomarkers;Stress;tandem mass spectrometry;Testing;Therapeutic Intervention;therapeutic target;therapy design;Time;Traumatic Brain Injury;United States;United States National Institutes of Health;Vascular Diseases;Veterans

PROJECT_TITLE: Traumatic Brain Injury and Vascular Disease


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: This project is of high relevance to the public health. Recently, the highly virulent strain of human fungal pathogen, Candida auris, has emerged as an important healthcare-associated microbe that has rapidly disseminated to multiple countries including the United States. This yeast is particularly concerning because it is often resistant to commonly used antifungal drugs, with some strains exhibiting resistance to all currently available classes of medication. Although outbreaks of Candida auris have only begun to be reported in VA patient populations, our patients have many of the risk factors for infection that have been identified in recent cohorts. These include hospitalization, particularly in ICUs, prior antibiotic exposure, immunosuppression, invasive procedures or indwelling catheters, and residence in assisted living or long-term care facilities. Our project aims to define factors associated with infection with Candida auris to better identify veterans and patients at risk of infection and persistent colonization.

PI_NAMEs: HISE, AMY G (contact)

PROJECT_TERMS: Adult;Affect;Amphotericin B;Animal Model;anti-fungal agents;Antibiotics;Assisted Living Facilities;Azoles;Body Weight decreased;Candida;Candida albicans;Candida auris;Caregivers;Cell model;Cells;Clinical;cohort;commensal microbes;Country;Data;Death Rate;dectin 1;demographics;density;Disease Outbreaks;Elderly;Emerging infection;emerging pathogen;Epithelial Cells;Exhibits;Feces;gastrointestinal;Goals;Growth;gut microbiome;Health;Health care facility;health care settings;Healthcare;high risk;Hospitalization;Human;Immune;immune activation;Immune response;Immunity;Immunologic Receptors;immunosuppressed;Immunosuppression;In Vitro;in vitro Model;in vivo Model;Indwelling Catheter;Infection;infection risk;Inflammasome;Innate Immune Response;Integration Host Factors;Intestines;Long-Term Care;Microbe;microbiome;microbiome alteration;Modeling;mouse model;Mucous Membrane;Multi-Drug Resistance;Mus;Mycoses;novel;Nursing Homes;Oral;oral microbiome;Oral mucous membrane structure;Outcome Assessment;pathogen;pathogenic fungus;Pathologic;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;Population;Predisposition;prevent;Procedures;Public Health;receptor;recruit;Reporter;Reporting;Research;Research Project Grants;residence;Resistance;resistance in Candida auris;Resistant candida;Risk;Risk Factors;screening;Sepsis;Severities;Surface;survival outcome;Time;Tissues;transmission process;United States;Veterans;Virulent;Yeasts

PROJECT_TITLE: Host factors affecting susceptibility to Candida auris.


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Gene Therapy;Genetics;Human Genome;Immunotherapy;Microbiome;Neuroblastoma;Neurosciences;Orphan Drug;Pancreatic Cancer;Rare Diseases;Transplantation;Women's Health Research

PI_NAMEs: SERODY, JONATHAN S. (contact)

PROJECT_TERMS: Acute;Acute Graft Versus Host Disease;Adaptive Immune System;Adoptive Cell Transfers;Affect;Allogenic;Antigens;B-Lymphocytes;biological systems;Biology;Breast;cancer cell;Cancer Center;Cancer Center Support Grant;cancer therapy;cancer vaccination;Cancer Vaccines;CAR T cell therapy;carcinogenesis;career;Catchment Area;CD276 gene;Cell Therapy;Cells;checkpoint therapy;chimeric antigen receptor T cells;chronic graft versus host disease;cigarette smoke;Clinical;Colorectal;Colorectal Cancer;Communities;community engagement;Community Outreach;cytokine;Development;Direct Costs;Disease;Doctor of Philosophy;Education;Evaluation;Faculty;Foundations;Funding;Genetic;Genomic approach;Genomics;Glioblastoma;graft vs host disease;graft vs leukemia effect;Grant;Growth;gut microbiota;Immune;immune function;Immune response;Immune system;Immunogenomics;Immunologic Receptors;Immunology;Immunotherapeutic agent;Immunotherapy;improved outcome;Inflammatory;informatics tool;innate immune function;Innate Immune System;innovation;Joints;Journals;Leadership;Lymphocyte;Lymphoid Cell;Lymphoma;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;medical schools;Medicine;member;Mentors;Mentorship;Microbiology;microbiome;microbiota;Multiple Myeloma;Myeloid-derived suppressor cells;Nanodelivery;neoplasm immunotherapy;Neuroblastoma;new therapeutic target;novel;novel strategies;Obesity;Outcome;outreach;Ovarian;Pancreas;Paper;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;peer;Play;Population;Postdoctoral Fellow;preclinical study;Process;professor;programs;Property;Publications;recruit;Regulatory Pathway;Regulatory T-Lymphocyte;Relapse;Research;Research Personnel;Resistance;response;Risk Factors;Role;Solid Neoplasm;Stem cell transplant;Strategic Planning;Students;T cell therapy;T-Lymphocyte;targeted treatment;Technology;The Cancer Genome Atlas;TNFRSF8 gene;Training;Training and Education;Translating;translational immunology;Translational Research;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor Subtype;Tumor Suppression;tumorigenesis;tumorigenic;undergraduate student;United States National Institutes of Health;virus related cancer;Work

PROJECT_TITLE: Immunology Research Program


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Immunization;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness;Vaccine Related

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The search for improved therapeutics to treat depression and other psychiatric illnesses has frequently been complicated by a need to simultaneously engage multiple downstream targets in order to achieve suitable efficacy. Presently, our understanding of ketamine's ability to act as an antidepressant is complicated by the potential of its active metabolite, hydroxynorketamine, to act through a different mechanism from the parent compound itself. This project aims to track emergent effects arising from the simultaneous actions of ketamine and hydroxynorketamine in the brain as a means to develop improved multi-target antidepressants.

PI_NAMEs: WENTHUR, CODY JAMES (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Ablation;abuse liability;Acute;Address;Adverse effects;AMPA Receptors;Anesthetics;Anhedonia;anti-depressive agents;Antibodies;Antibody Affinity;Antibody Formation;Behavior;Behavioral;Behavioral Model;behavioral outcome;Binding;biological adaptation to stress;Brain;brain tissue;Central Nervous System Diseases;Chemicals;Clinical;combinatorial;Complex Mixtures;design;Disease Management;Drug Kinetics;drug maintenance;drug reward;Enzyme-Linked Immunosorbent Assay;Event;experimental study;Face;Formulation;FRAP1 gene;Glutamates;Haptens;Hippocampus;Immunofluorescence Immunologic;improved;in vivo;Individual;Ketamine;Label;LacZ Genes;Light;Major Depressive Disorder;Maps;Measures;Mediating;Mental Depression;Mental disorders;Metabolic;Methods;Microscopy;Molecular;Molecular Target;Monoclonal Antibodies;Mus;Neuronal Plasticity;Neurons;Neurosciences;Outcome;Parents;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;Population;preservation;prevent;Protocols documentation;rational design;Rattus;recruit;Resolution;Risk;Role;scaffold;side effect;Signal Transduction;small molecule;small molecule therapeutics;Source;Synaptosomes;System;Techniques;Testing;theories;Therapeutic;Therapeutic Effect;tool;Transcriptional Regulation;Treatment Efficacy;treatment-resistant depression;Vaccination;Vaccines;Vision;Work

PROJECT_TITLE: Deconvoluting Polypharmacologic Contributions of Rapidly-Acting Antidepressants


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Lung;Mental Health;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE A growing number of patients are surviving Acute Respiratory Failure (ARF), but may experience long-lasting psychological problems after returning home. Early, evidenced-based treatment to reduce psychological symptoms in the intensive care unit and hospital may help improve patient outcomes, but research evaluating such treatment for ARF patients is scant. This project includes qualitative research that tailors an existing psychological intervention for use in ARF patients, then subsequently conducts a pilot randomized controlled trial to evaluate the feasibility, acceptability, and potential benefit of the psychological intervention on ARF patients’ anxiety and associated outcomes at hospital discharge and 3-month follow-up.

PI_NAMEs: HOSEY, MEGAN  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: acceptability and feasibility;Acute respiratory failure;Address;Adult;American Psychological Association;Anxiety;anxiety management;anxiety reduction;anxiety symptoms;avoidance behavior;awake;Award;Bed rest;career;Chronic Disease;Clinical;clinical investigation;clinical practice;clinically significant;cost;Critical Care;Data;death anxiety;debilitating symptom;Delirium;depressive symptoms;design;Doctor of Philosophy;Dropout;Early Intervention;Enrollment;Environment;Evaluation;evidence base;evidence based guidelines;Evidence based intervention;Evidence based treatment;experience;Feedback;Feeling;follow up assessment;follow-up;Foundations;Fright;functional outcomes;Funding;Future;Goals;Grant;Guidelines;Health Sciences;Home;Hospitalization;Hospitals;Impairment;improved;improved outcome;Intensive Care Units;Intervention;Interview;Knowledge;Measures;Mechanical ventilation;Medical;medical schools;Medicine;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;mortality;National Heart, Lung, and Blood Institute;Nonpharmacologic Therapy;novel;Outcome;Outcome Measure;Pathway interactions;patient oriented;patient oriented research;Patient Recruitments;Patient-Focused Outcomes;Patients;Pattern;Population;primary outcome;professor;psychologic;psychological distress;psychological outcomes;psychological symptom;Psychologist;psychosocial;Publications;Qualitative Research;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;Rehabilitation therapy;Reporting;Research;Research Personnel;Resources;Scientist;secondary outcome;Sedation procedure;sedative;Self Efficacy;Self Management;side effect;skills;Societies;Solid;Structure;Survivors;Telephone;Titrations;Training;treatment as usual;usual care arm;Wakefulness;ward;Writing

PROJECT_TITLE: Improving Psychological Outcomes for Acute Respiratory Failure Survivors using a Self-Management Intervention

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF TORONTO

ORG_STATE: ON

ORG_ZIPCODE: M5S 1S8

PHR: The heritability of complex traits, including disease, is governed by a complex interplay of many genetic variants. This project will produce unique datasets and tools that will reveal how groups of genes interact with each other and how networks of genetic interactions are rewired in response to different genetic backgrounds. The genetic interaction maps produced by the project will provide insights into gene function, an overall view of the functional organization of a human cell and provide a template for understanding the link between genotype and phenotype, including the genetic basis of human disease.

PI_NAMEs: ANDREWS, BRENDA JEAN (contact);BOONE, CHARLES ;MYERS, CHAD L

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Address;Alleles;Biological;Biological Assay;cancer cell;Cell Cycle;Cell Physiology;Cells;cellular imaging;Cellular Morphology;Chromosome Mapping;Collection;Complex;CRISPR/Cas technology;Data Set;data tools;Dependence;design;Disease;Environment;Essential Genes;Eukaryota;Eukaryotic Cell;Experimental Designs;fitness;Funding;Gene Deletion;gene function;gene interaction;Genes;Genetic;genetic analysis;Genetic Determinism;Genetic study;genetic variant;Genetic Variation;Genome;genome sequencing;genome-wide;Genotype;Grant;Hereditary Disease;Heritability;Human;Human Cell Line;human disease;Human Gene Mapping;Human Genetics;Human Genome;Image;Image Analysis;imaging platform;improved;Individual;Inherited;innovation;insight;Link;Maps;Measurement;member;Methods;Modeling;Morphology;mutant;Outcome;personalized medicine;Phenotype;Play;population based;Positioning Attribute;Prevalence;Property;protein complex;Proteome;Research;Resources;response;Role;Saccharomyces cerevisiae;Saccharomycetales;scaffold;screening;Stress;Structure;temperature sensitive mutant;Testing;trait;Variant;Work;yeast genetics;Yeasts

PROJECT_TITLE: Mapping dynamic functional networks across environments and backgrounds

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: DAVIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: NARRATIVE Proton therapy is more effective on attacking tumors compared to conventional therapy with photons, however, the risk of damaging healthy tissue surrounding the cancerous region is higher. Monitoring where in the patient the radiation dose is being deposited is challenging for certain regions of the body with high density heterogeneity, such as the lungs, with significant respiratory motion, like liver, or where extreme precision is needed to avoid toxicity in critical neighbor organs, such as in head and neck cancers. In this project, we aim to test the novel Cerenkov charge induction (CCI) thallium bromide (TlBr) detectors for real time monitoring of proton therapy in the challenging scenarios described before.

PI_NAMEs: ARIÑO ESTRADA, GERARD  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Anodes;attenuation;beamline;Biomedical Engineering;Body Regions;Bromides;Calibration;cancer therapy;Cancerous;Charge;Clinical;Collimator;conventional therapy;Cyclotrons;Data Set;Dedications;density;Deposition;Detection;detection platform;detector;Devices;Digital Signal Processing;Dimensions;Dose;Electrodes;Electrons;Face;falls;feasibility testing;Film;Gamma Rays;Goals;Head and Neck Cancer;Head and neck structure;Health Services Accessibility;Healthcare;Heterogeneity;Image;improved;in vivo;Institution;instrumentation;Laboratories;Length;Letters;Light;Liver;Location;Lung;manufacture;Methods;Modeling;Monitor;Motion;nanosecond;Nature;novel;Nuclear;operation;Operative Surgical Procedures;Organ;Outcome;Parents;particle;Patients;Performance;photomultiplier;photonics;Photons;Positioning Attribute;preservation;printed circuit board;proton beam;proton therapy;Protons;prototype;Radiation;Radiation Dose Unit;Radiation therapy;Radioactive;real time monitoring;Research Project Grants;Resolution;respiratory;response;Risk;Scanning;seal;Semiconductors;signal processing;Silicon;Source;Spectrum Analysis;Surface;Techniques;Testing;Thallium;Time;Tissues;Toxic effect;Treatment Efficacy;Treatment Protocols;tumor;Uncertainty;Work;X-Ray Computed Tomography

PROJECT_TITLE: Real-time in vivo proton range verification in proton therapy with thallium bromide detectors

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Pediatric;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: KINGSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF RHODE ISLAND

PHR: Project Narrative Hispanic youth are nearly three times as likely to be at high risk for developmental delays compared to white non-Hispanic children because of disproportionate exposure to early adversity, which is biologically embedded via epigenomic changes. This study aims to understand how changing social context alters the epigenome among at-risk young Hispanic children and potentially ameliorates the biological embedding of adversity. We will also examine epigenomic biosignatures of response to early intervention that will result in innovative approaches to risk identification, the advancement of personalized prevention and intervention, and, ultimately, to a reduction of health disparities.

PI_NAMEs: PARENT, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TERMS: accelerated epigenetic aging;Accounting;Aftercare;Age;age acceleration;Aging;Attenuated;Behavioral;behavioral outcome;Bioinformatics;Biological;biological adaptation to stress;Biological Markers;biological systems;biosignature;Buffers;Child;Child Behavior;Child Rearing;Chronic Disease;Clinical;Clinical Trials;Data;design;Development;Developmental Delay Disorders;disadvantaged background;Disparity;DNA Methylation;early detection biomarkers;early experience;Early Intervention;early life adversity;economic disparity;Educational Intervention;Environmental Impact;epigenetic clock;Epigenetic Process;epigenome;epigenome-wide association studies;epigenomics;evidence base;Exposure to;follow-up;Foundations;Funding;Future;Genes;Glucocorticoids;group intervention;high risk;Hispanic;Home;Human;improved;individualized prevention;Inflammatory;Inflammatory Response;Informal Social Control;informant;innovation;Interdisciplinary Study;Intervention;intervention program;Knowledge;Latinx;Life;Literature;Maintenance;Measures;Methods;methylomics;Molecular Biology;mood regulation;Neurosecretory Systems;Not Hispanic or Latino;Outcome;parental role;parenting intervention;Parents;Pathway Analysis;Pathway interactions;Pattern;personalized care;personalized intervention;personalized medicine;Poverty;precision medicine;prevent;Prevention;Prevention approach;Prevention program;preventive intervention;Process;promote resilience;protective factors;Psychopathology;Public Health;public health relevance;Randomized;Randomized, Controlled Trials;Reduce health disparities;Research;resilience;response;response biomarker;Risk;Role;Scientist;service intervention;Signal Transduction;Signaling Protein;Site;social;Social Change;Social Environment;Standardization;Stress;stressor;Time;Training Programs;Trauma;treatment response;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Epigenomic mechanisms of risk and resilience: The role of parenting

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(55)R]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Climate-Related Exposures and Conditions;Genetics;Human Genome;Skin Cancer

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative: While UV light causes many mutations during the development of skin cancers like melanoma, most driver mutations that contribute to disease progression do not display traditional characteristics of being caused by UV damage. This proposal will investigate the formation and mutagenic potential of rare atypical photoproducts at TA, CA, and AC dinucleotides in response to physiologically relevant UVB light, assess whether such lesions are sensitive to photo-reactivation by cyclobutane pyrimidine dimer and 6-4 photoproduct photolyases, utilize novel methods to map the location of TA photoproducts across genomes, and determine which DNA polymerases are involved in the mutagenic bypass of these lesions. Successful completion of these aims will establish a critical link between UV exposure and melanomagenesis as mutation of CA and AC dinucleotides are common diver mutations in the BRAF proto-oncogene.

PI_NAMEs: ROBERTS, STEVEN A;WYRICK, JOHN J (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Acute;Adenine;Bioinformatics;BRAF gene;Bulla;Bypass;Cells;Characteristics;Clinical;Cutaneous Melanoma;Cytidine;Cytosine;Data;Deamination;density;Deoxyribonuclease I;Dinucleoside Phosphates;Disease Progression;DNA biosynthesis;DNA Damage;DNA-Directed DNA Polymerase;driver mutation;Epidemiology;Etiology;experimental study;Exposure to;Genetic Transcription;Genome;genome sequencing;genome-wide;genome-wide analysis;Genomics;High-Throughput Nucleotide Sequencing;Human;In Vitro;Incidence;Induced Mutation;insight;Lesion;Light;Link;Location;Maps;Melanoma;melanomagenesis;Methods;Molecular;Mutagenesis;Mutation;novel;Nucleotide Excision Repair;Nucleotides;Oncogenic;Physiological;Play;Polymerase;Proto-Oncogenes;Pyrimidine Dimers;Rad30 protein;Rare Lesion;Recurrence;regional difference;repaired;Reporter;Resolution;response;Role;Skin;Skin Cancer;skin organogenesis;Somatic Mutation;Sunburn;Sunlight;Thymine;tumor;tumor progression;ultraviolet;Ultraviolet B Radiation;ultraviolet damage;ultraviolet lesions;Ultraviolet Rays;UV induced;UV Mutagenesis;UV Radiation Exposure;UVA induced;whole genome;Yeasts

PROJECT_TITLE: Genome-wide analysis of the formation and mutagenesis of atypical UV photoproducts in skin cancer


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PI_NAMEs: FRYE, STEPHEN VERNON (contact)

PROJECT_TERMS: Acceleration;Address;Animal Model;animal resource;anti-cancer research;Antineoplastic Agents;Area;Award;Basic Science;Biological Products;Biological Response Modifier Therapy;Biology;Breast;Cancer Center;Cancer Center Support Grant;cancer therapy;cancer type;Catchment Area;Cell Therapy;Chemicals;cheminformatics;Clinical;Clinical Research;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Communities;community engagement;Community Outreach;Computer Assisted;Computer Models;Critiques;Cryoelectron Microscopy;Death Rate;Dedications;design;Development;Direct Costs;Discipline;distinguished professor;Drug Delivery Systems;Drug Design;drug development;drug discovery;Drug Formulations;Drug Kinetics;Environment;Enzymes;Epigenetic Process;Extramural Activities;Faculty;Formulation;Funding;Future;Genetically Engineered Mouse;Genomics;Goals;Grant;Guanosine Triphosphate Phosphohydrolases;health care disparity;high throughput screening;Home;human model;imaging modality;Immunotherapy;improved;in vivo Model;Incidence;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Intervention;Investments;Lead;lead optimization;Leadership;Lipids;live cell imaging;Lung;macromolecule;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;member;Minor;Molecular;Molecular Biology;mortality;Multiple Myeloma;Mus;Nanodelivery;nanoparticle;Nanotechnology;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Pancreas;Paper;Pathway interactions;patient derived xenograft model;Patients;peer;Pharmaceutical Chemistry;Pharmacodynamics;pharmacologic;Pharmacology;Phase;Phospholipase;Phosphotransferases;Positioning Attribute;Postdoctoral Fellow;pre-clinical assessment;Productivity;programs;Prostate;Protein Engineering;Proteins;Proteomics;Publishing;receptor;recruit;Research;Research Personnel;Resolution;Resource Sharing;Resources;response;RNA interference screen;Schools;Signal Transduction;small molecule;Strategic Planning;structural biology;student training;System;Technology;Therapeutic;Therapeutic Research;Therapeutic Studies;Therapeutic Trials;tool;Toxic effect;Training and Education;Translating;translational scientist;Translational trial;Translations;Viral;X-Ray Crystallography

PROJECT_TITLE: Molecular Therapeutics Research Program

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Non-alcoholic fatty liver disease (NAFLD) is a burden on our healthcare system due to the lack of an efficient therapy. We will define how methionine metabolism is regulated by peroxisome proliferator-activated receptor γ in hepatocytes to promote NAFLD. Our results will help to develop therapeutic approaches that improve the use of existing drugs to reverse efficiently this disease.

PI_NAMEs: CORDOBA-CHACON, JOSE  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Adipocytes;Adult;Anti-Inflammatory Agents;betaine-homocysteine methyltransferase;Caring;Cells;Cholesterol;chronic liver disease;clinical care;clinically relevant;Data;defined contribution;Dependovirus;Development;diabetogenic;Diet;Disease;Dose;Enzymes;expectation;experimental study;Extrahepatic;Fatty acid glycerol esters;FDA approved;fibrogenesis;Fibrosis;Fructose;Gene Expression;General Population;Health;Healthcare Systems;Hepatic;Hepatic Stellate Cell;Hepatic Tissue;Hepatocyte;Homocysteine;Human;improved;In Vitro;in vivo;Inflammation;innovation;Insulin Resistance;Knock-out;Label;Lecithin;Lipids;Liver;liver injury;Macrophage;Mediating;Messenger RNA;metabolomics;Methionine;Methionine Metabolism Pathway;methyl group;Methylation;Mus;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Outcome;Patients;Perfusion;Pharmaceutical Preparations;Pharmacological Treatment;Phosphatidylethanolamine N-Methyltransferase;PPAR gamma;Prevalence;Regulation;restoration;Testing;Therapeutic;Therapeutic Effect;Thiazolidinediones;Very low density lipoprotein

PROJECT_TITLE: PPARgamma-regulated mechanisms in hepatocytes that promote NAFLD

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE This project involves the collection of data related to connections between regions of the brain important for maintaining standing balance in elderly fall-risk individuals. Falls are the leading cause of accidental death in older adults, and the goal of this work is to characterize important circuit interactions that may underlie fall risk by investigating the roles of motor and cognitive neural circuits that contribute to balance control. In the future, this work will help identify potential biomarkers and targets for more individualized rehabilitation therapies to improve balance function and quality of life in older individuals at risk for falls.

PI_NAMEs: MASON, CATHERINE FRANCOISE (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Accidents;Adult;Age;age effect;age group;age related decline;Aging;Area;Attention;Biological Markers;Brain region;Cessation of life;Clinical;Clinical Trials;Cognition;Cognitive;cognitive ability;cognitive task;Collaborations;Compensation;conditioning;Data Collection;Disease;early detection biomarkers;Effectiveness;Elderly;equilibration disorder;Equilibrium;fall risk;falls;Future;Goals;Impaired cognition;Impairment;improved;Individual;Individual Differences;Intervention;Investigation;Knowledge;Leg;Lower Extremity;Mathematics;Measures;Mentors;mild cognitive impairment;Mobility decline;Motor;Motor Cortex;Motor Evoked Potentials;Motor Pathways;National Research Service Awards;neural circuit;Neurobiology;Neuromechanics;neurophysiology;neuroregulation;older adult;Older Population;Output;Participant;Pathology;Pathway interactions;Physiologic pulse;Physiological;Posture;potential biomarker;Predisposition;Prefrontal Cortex;Psyche structure;Quality of life;recruit;rehabilitation strategy;Rehabilitation therapy;Research;Research Design;Resources;response;Role;Site;Task Performances;Testing;Training;Transcranial magnetic stimulation;Work

PROJECT_TITLE: The effect of aging and cognitive impairment on prefrontal cortical inputs to motor cortical outputs during standing balance control


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Emergency Care;Health Services;Neurosciences;Patient Safety

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: The purpose of this application is to renew a previously established regional network of prehospital and hospital systems of care that will improve health outcome for patients with emergency medical conditions affecting heart, brain, lung, and/or blood, as well as life-threatening trauma through the conduct of clinical trials involving these disciplines.

PI_NAMEs: JOHNSON, NICHOLAS J;KUDENCHUK, PETER JAMES (contact)

PROGRAM_OFFICER_NAME: SCOTT, GRETCHEN CARLYLE

PROJECT_TERMS: Academic Medical Centers;Address;Affect;Blood;Brain;British Columbia;care systems;Clinical Trials;Clinical Trials Network;Communities;Conduct Clinical Trials;County;Discipline;Emergency Care;Emergency medical service;Emergency Situation;Enrollment;Faculty;Health;Heart;hospital care;Hospitals;improved;innovation;Institutional Review Boards;Leadership;Life;Lung;Medical emergency;Network Infrastructure;Pacific Northwest;Patient-Focused Outcomes;Pragmatic clinical trial;Provider;Public Health;Resources;Role;Site;Trauma;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: University of Washington HUB Network for Emergency Care Clinical Trials: Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN)