NIH_SPENDING_CATS: Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative Magnetic resonance (MR) is a safe method for imaging that does not rely upon ionizing radiation. We will develop MR detection of hyperpolarized 13C-labeled and thermally polarized, 2H-labeled substrates as markers of metabolic dysfunction in nonalcoholic fatty liver disease and in nonalcoholic steatohepatitis. Our overall goal is to develop a robust, safe, MR based assessment of hepatic energy metabolism that can be applied to diagnose and stage these diseases.

PI_NAMEs: MERRITT, MATTHEW E (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Acetyl Coenzyme A;Acetyl-CoA Carboxylase;Anatomy;Biological Assay;Biology;Biopsy;Bypass;C57BL/6N Mouse;Caprylates;Carbohydrates;Carbon;Carnitine;Cessation of life;Citric Acid Cycle;Classification;Clinical;clinical imaging;Clinical Management;clinical translation;cost;Dangerousness;Deposition;Detection;Development;Diagnosis;Diagnostic;Diet;Dihydroxyacetone;Disease;Disease Management;disease model;Elements;Energy Metabolism;enzyme activity;Epidemic;FADH2;Fatty acid glycerol esters;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Fibrosis;Fumarate Hydratase;Futile Cycling;Genetic;Genetic Models;global health;glucose metabolism;glucose production;Goals;Healthcare;Healthcare Systems;Hemorrhage;Hepatic;Hepatitis;Heterogeneity;human imaging;human model;Image;imaging approach;imaging detection;imaging modality;imaging platform;Imaging Techniques;Imaging technology;improved;Inflammation;insight;Ionizing radiation;kinetic model;Kinetics;Knock-out;Knockout Mice;Label;Link;Lipids;Liver;liver metabolism;liver transplantation;loss of function;Magnetic Resonance;Magnetic Resonance Elastography;malic enzyme;Mass Spectrum Analysis;Measurement;Medium chain fatty acid;Metabolic;Metabolic dysfunction;metabolic imaging;Metabolic Marker;Metabolism;Methods;Modeling;Molecular;Monitor;Mus;NADH;Needle biopsy procedure;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Palmitates;Pathogenesis;Pathologic;Pathway interactions;Patient Care;Perfusion;Phosphoenolpyruvate Carboxylase;Population;Prevalence;Production;Pyruvate;Pyruvate Carboxylase;pyruvate dehydrogenase;Pyruvate Kinase;Pyruvate Metabolism Pathway;Reactive Oxygen Species;Risk;Rodent Model;Sampling Biases;Signal Transduction;Staging;Surrogate Markers;Testing;Time;Tissues;Tracer;Transferase;translational potential;Tricarboxylic Acids;ultrasound;United States;Water;Work

PROJECT_TITLE: Imaging Hepatic Energy Metabolism in NAFLD/NASH

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Immunotherapy;Infectious Diseases;Liver Disease;Nanotechnology;Prevention

ORG_CITY: OMAHA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: We will convert oral daily HBV treatment regimen (tenofovir and entecavir) and an immunomodulatory agent (tizoxanide) into medicines that can be administered once every two months. Lipophilic nanocrystals will be made from modified parent drugs then evaluated using in vitro and in vivo models to identify a safe and more effective two drug regimen to facilitate a functional cure strategy for HBV infection.

PI_NAMEs: EDAGWA, BENSON ;OSNA, NATALIA ALEKSANDR;POLUEKTOVA, LARISA Y (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: adaptive immune response;Adherence;AIDS prevention;alcohol abuser;analog;Anti-Retroviral Agents;Anti-viral Agents;Biodistribution;Biological Availability;Bypass;Cells;Chromosomes;Chronic Hepatitis B;Clinical;clinical translation;Clinical Trials;Collaborations;Complex;controlled release;Development;Dose;drug action;Drug Delivery Systems;drug efficacy;Drug Formulations;Drug Interactions;Drug Kinetics;drug metabolism;efficacy study;end stage liver disease;Ensure;entecavir;experience;forging;Formulation;Frequencies;Generations;Goals;Half-Life;Hepatitis B;Hepatitis B Antiviral;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis Viruses;Hepatocyte;HIV-1;Human;humanized mouse;Hydrophobicity;immune modulating agents;immune stimulant;Immunity;Immunomodulators;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;Individual;Infection;inhibitor;Injectable;Innate Immune Response;Interferon Alfa-2a;Interferon alpha;Interferons;Intramuscular Injections;Kupffer Cells;lipophilicity;Liver;Liver diseases;Liver Fibrosis;Macrophage;Malignant neoplasm of liver;manufacturing facility;Medicine;Modeling;Mus;nano;nanocrystal;nanoformulation;nanomedicine;nanoparticle;Natural Immunity;Nebraska;nitazoxanide;Oral;Oral Administration;Parents;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phenotype;pill;Polymerase;prevent;Prevention;Prodrugs;Property;Protocols documentation;Protozoa;Recommendation;Regimen;response;Safety;side effect;Signal Pathway;Site;substance abuser;Suspensions;Technology;Tenofovir;Testing;Therapeutic;Toxic effect;Treatment Efficacy;Treatment outcome;Treatment Protocols;uptake;Viral;viral DNA;viral liver disease;Viral Physiology;Virus Diseases;Virus Replication;Vulnerable Populations;Water

PROJECT_TITLE: New generation of long acting nucleos(t)ides and immune stimulant for treatment of chronic hepatitis B

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Antimicrobial therapy can lead to disruption of the gut microbiome and infection with Clostridioides difficile, a disease associated with high morbidity and mortality, particularly among the elderly. Drawing on observations that pet ownership and close contact with pets are protective against colonization with C. difficile and recurrence of C. difficile infection, the proposed study will test the hypothesis that microbiota that provide colonization resistance against C. difficile are shared between patients and their pets and that pet contact can mitigate antimicrobial-associated gut dysbiosis and the risk of C. difficile infection. This study will further define epidemiologic and pathophysiologic characteristics of C. difficile infection and gut microbiome dysbiosis that could enhance therapeutic options for these conditions, potentially through non-invasive interventions involving animal contact.

PI_NAMEs: REDDING, LAUREL ELIZABETH (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Age Years;Animals;antimicrobial;Asthma;atopy;Bioinformatics;career;career development;Cessation of life;Characteristics;Clinical;Clostridium difficile;colonization resistance;Communities;Data;Dedications;deep sequencing;Dental Implants;Development;Development Plans;Diarrhea;Disease;dysbiosis;Ecology;Elderly;Environment;Epidemiology;experience;fecal transplantation;Foundations;functional restoration;Future;gut dysbiosis;gut microbiome;gut microbiota;Health;Healthcare;Human Microbiome;improved;Indigenous;Infection;Infectious Disease Epidemiology;Intervention;Longitudinal cohort study;Mentors;Metabolic;Methods;microbial;Microbiology;microbiome;microbiome composition;microbiome research;microbiome therapeutics;microbiota;Morbidity - disease rate;mortality;novel;older patient;Outcome;Ownership;pathogen;pathogenic bacteria;patient oriented research;Patients;Pennsylvania;Persons;pet animal;Physical activity;prevent;Proliferating;prophylactic;prospective;protective effect;Pseudomembranous Colitis;Recovery;Recurrence;Research;Research Personnel;Research Proposals;restoration;Risk;Sampling;Source;statistics;stress reduction;success;Testing;Therapeutic;Therapeutic Intervention;Training;University resources;user-friendly

PROJECT_TITLE: Impact of pet contact on antimicrobial-associated dysbiosis and Clostridioides difficile infection

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Rectal cancer represents a growing problem, because it is increasingly diagnosed in people in the prime of life; however, research into new treatments has been hampered because current models of rectal cancer poorly represent patient tumors. Our goal is to develop rectal cancer organoids (tumoroids) as models for rectal cancer research and to establish whether the tumoroids allow for prediction of individual patients' responses to the components of standard treatment, including chemotherapy or radiotherapy. The ultimate result will be expansion of patient-specific research tools, accelerated discovery of new treatment options for rectal cancer patients, and eventually better treatment decisions for individual patients.

PI_NAMEs: SMITH, JESSE JOSHUA  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;Anatomy;anti-cancer research;biobank;Bioinformatics;Biology;Biometry;cancer genomics;Cancer Patient;cBioPortal;Cell Culture Techniques;Cell Line;chemotherapy;Chemotherapy and/or radiation;Clinical;clinically relevant;Collection;colon cancer cell line;Colorectal Surgery;Communities;Complex;Credentialing;Data;Development;Diagnosis;Disease;effective therapy;Environment;flexibility;Gene Expression;Genitourinary system;Genomics;Goals;Histology;Human;Implant;implantation;in vivo;in vivo Model;Incidence;Individual;individual patient;individual response;Injections;Institution;interest;Invaded;Investigation;KRAS2 gene;Life;Location;Malignant Neoplasms;Memorial Sloan-Kettering Cancer Center;Modeling;Molecular;mouse model;Mus;Mutation;Neoadjuvant Therapy;Neoplasm Metastasis;Operative Surgical Procedures;Organ;Organoids;Pathologic;Pathology;patient derived xenograft model;patient response;Patient Selection;Patients;Pelvis;Persons;Physiological;pilot test;pre-clinical;predicting response;predictive tools;Quality of life;Radiation;Radiation Oncology;Radiation therapy;Rectal Adenocarcinoma;Rectal Cancer;Rectum;repository;Research;Resources;response;Selection for Treatments;standard care;standard of care;subcutaneous;success;Surgical Oncology;survival outcome;Testing;tool;TP53 gene;trait;transcriptome;Transplantation;treatment response;tumor;Tumor Tissue;two-dimensional

PROJECT_TITLE: Expansion of Tumoroid Models for Precise Treatment of the Rectal Cancer Patient

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-J(55)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Hematology;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human;Transplantation

ORG_CITY: Columbus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Loss of hematopoietic stem cell diversity can occur after administration of cytotoxic chemotherapy, stem cell transplantation, or toxin exposure, leading to cytopenias or other blood disorders and decreasing the quality and length of life. This project aims to understand how the cellular niche surrounding the hematopoietic stem cell is able to modify its gene expression program in order to be able to support hematopoiesis. These studies may lead to new therapies that can expand the hematopoietic capacity of the niche, aid recovery of hematopoiesis with a phylogenetically and functionally diverse population of stem cells, and prevent the devastating late complications of chemotherapy on the blood system.

PI_NAMEs: BLASER, BRADLEY WAYNE (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Adult;ANGPT1 gene;Animals;ATAC-seq;Bar Codes;Binding;Binding Sites;Blood;Blood Vessels;Bone Marrow;Cell Culture Techniques;Cell Line;cell type;Cells;chemotherapy;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clonal Hematopoietic Stem Cell;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;CRISPR screen;cytopenia;Cytotoxic Chemotherapy;Data;Development;Developmental Process;DNA;Elements;Embryo;Endothelial Cells;Enhancers;Epigenetic Process;Erythroid;Erythroid Progenitor Cells;Fertilization;Gene Expression;Genes;Genetic Enhancer Element;Genetic Screening;Genetic Transcription;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic stem cell fate;hematopoietic stem cell niche;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;Homologous Gene;Human;improved;In Vitro;in vitro Assay;in vivo;Kidney;KITLG gene;Link;Longevity;Marrow;Molecular;Morbidity - disease rate;mortality;multimodality;mutant;Natural regeneration;neutrophil;NF-kappa B;novel;novel therapeutics;Organ;Outcome;overexpression;Patients;Phenotype;Phylogenetic Analysis;Population;Population Heterogeneity;prevent;Process;programs;promoter;Promoter Regions;reconstitution;Recovery;Regulation;Role;Signal Transduction;Signaling Molecule;single cell ATAC-seq;single-cell RNA sequencing;Source;stem cell biology;stem cell population;Stem cell transplant;Stromal Cell-Derived Factor 1;System;therapy development;Tissues;Toxin;transcription factor;Transcriptional Regulation;Transplantation;unpublished works;Work;Zebrafish

PROJECT_TITLE: Epigenetic control of vascular niche capacity to support hematopoiesis.

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


ADMINISTERING_IC: AG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The proposed research will develop a new  measurements of the retina. This new technology will be built into existing devices that are currently used to image disease in the retina, providing a simple way for clinicians to evaluate patients using a simple retinal scan. This would have significant implications for detecting and managing diagnostic that can be widely used at a lower cost than current methods.

PI_NAMEs: WAX, ADAM  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: adaptive optics;Age;Aging;Alzheimer disease detection;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease diagnostic;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid deposition;Anatomy;Animal Model;Animals;Autopsy;Barrett Epithelium;Barrett Esophagus;Biological Markers;biomarker development;biomarker validation;brain tissue;cellular imaging;Cellular Structures;Central Nervous System;Cerebrospinal Fluid;Cervical;Cervix Uteri;Characteristics;Clinical;clinical biomarkers;clinical diagnostics;Clinical Research;Cone;cost;Crystalline Lens;Data;Data Analyses;Dementia;Descriptor;Detection;detection method;Development;Devices;Diagnosis;Diagnostic;diagnostic platform;diagnostic tool;Discrimination;Disease;early onset;Epithelium;Esophagus;Evaluation;Exclusion Criteria;Eye diseases;Functional impairment;Future;Ganglion Cell Layer;Glaucoma;Goals;Health;Human;Image;Impaired cognition;in vivo;Individual;Interferometry;Investigation;Label;light scattering;Link;Machine Learning;machine learning algorithm;Measurement;Measures;Meta-Analysis;Methods;Morphology;mouse model;nephelometry;Neurodegenerative Disorders;Neurology;new technology;novel;Nuclear;Onset of illness;Ophthalmology;Optic Nerve;Optical Coherence Tomography;organizational structure;Pathologic;Pathology;Patients;Photophobia;Photoreceptors;Population;Positron-Emission Tomography;Premalignant Cell;prevent;Probability;Prospective Studies;Recording of previous events;Research;Resolution;Retina;retinal imaging;retinal nerve fiber layer;Rod;Scanning;Senile Plaques;Spinal Puncture;Structure;System;Techniques;Technology;Technology Assessment;Testing;Thick;Thinness;Tissues;Translating;Work

PROJECT_TITLE: Retinal Light Scattering Measurements as a Clinical Biomarker of Alzheimer's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Pericytes are a key cell type in the capillary wall, and their deficiency during Alzheimer’s disease leads to impairment of important vascular functions, such as blood-brain barrier integrity and regulation of blood flow. This project uses cutting-edge live imaging to study the dynamics of brain pericytes in live mice, with the goal of revealing how the brain responds and adapts to pericyte loss. It will also test whether augmentation of pericyte-endothelial coverage can improve capillary health and function in adult and aged brains.

PI_NAMEs: SHIH, ANDY Y (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Ablation;Acceleration;Address;Adult;Affect;Age;age-related disease;aged;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Autopsy;Basement membrane;Biology;Blood - brain barrier anatomy;Blood capillaries;Blood flow;Blood Vessels;Brain;brain dysfunction;brain pericytes;capillary bed;cell type;Cells;cerebral capillary;Cerebral cortex;cerebrovascular;Cerebrovascular Disorders;cerebrovascular health;Communication;Compensation;Data;Development;Endothelium;Event;Gene Expression;Genetic;genetic manipulation;Goals;Health;hemodynamics;Histologic;Hypoxia;Image;imaging probe;Impairment;improved;in vivo;in vivo calcium imaging;in vivo imaging;in vivo two-photon imaging;innovation;insight;Invaded;Investigation;knock-down;Knowledge;Life;Maintenance;Measures;Methods;middle age;Modeling;multidisciplinary;Mus;Mutant Strains Mice;neural;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;neurovascular;novel;old mice;Optics;Oxygen;PDGF inhibition;PDGFRB gene;Peptides;Pericytes;pharmacologic;Physiological;Platelet-Derived Growth Factor;platelet-derived growth factor BB;Platelet-Derived Growth Factor beta Receptor;preservation;Process;recruit;Regulation;repair strategy;repaired;reparative process;Reporting;Resolution;response;Role;Severities;Signal Pathway;Signal Transduction;Stretching;Structure;Synapses;synaptic function;Testing;Theft;tissue oxygenation;Tissues;two photon microscopy;two-photon;Work

PROJECT_TITLE: Pericyte structural plasticity and cerebrovascular health


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: LEXINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: The project will develop critical resources to enhance research efforts using the laboratory axolotl (Ambystoma mexicanum). Improvements to the axolotl genome assembly will be made, epigenetic data will be generated for limb and tail regeneration, and all data from the project will be made publicly available. Studies using the axolotl may reveal strategies to achieve endogenous tissue regeneration in humans.

PI_NAMEs: SMITH, JERAMIAH JAMES;VOSS, STEPHEN RANDAL (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Achievement;Adult;Ambystoma;Ambystoma mexicanum;Amphibia;Animal Model;Area;Base Sequence;Bioinformatics;bioinformatics resource;Biology;Biomedical Research;Body part;Brain;cell type;ChIP-seq;Chromatin;Chromosomes;Communities;Complex;Data;data dissemination;data integration;Data Set;data sharing networks;design;Development;disease model;DNA Binding;DNA sequencing;Embryo;empowerment;Enhancers;Ensure;Environment;Epigenetic Process;experience;Funding;Gene Expression;Generations;Genes;Genetic;genetic pedigree;Genetic Transcription;Genetic Variation;Genome;genome browser;genome editing;genome resource;genome-wide analysis;genomic data;Genomics;Growth;Haploidy;histone-binding proteins;Histones;Human;human tissue;Hybrids;improved;innovation;knowledgebase;Laboratories;limb regeneration;Limb structure;Methods;Modeling;Molecular;Natural regeneration;Phase;Positioning Attribute;Post-Translational Protein Processing;promoter;Protocols documentation;Publishing;Reagent;Recommendation;regeneration model;Regenerative research;Repetitive Sequence;Research;Research Personnel;Resources;Salamander;Sampling;Site;Spinal Cord;stem cells;System;Tail;Tetrapoda;Tigers;Time;tissue regeneration;Tissues;Translating;Untranslated RNA;user-friendly;Variant;web portal

PROJECT_TITLE: Research Resources for Model Amphibians

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-G(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: TAMPA

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Relevance to Public Health The lack of reliable detection methods of small amyloid oligomers in vivo has hampered elucidating their contributions to Alzheimer's Disease and related disorders. This projects aims to identify and validate new fluorescent probes for reliable detection of the elusive and transient amyloid oligomers. Such oligomer-selective dyes are highly promising candidates for developing in vivo PET imaging probes for oligomer detection in patients.

PI_NAMEs: KANG, DAVID E;MUSCHOL, MARTIN  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta oligomer;Address;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;amyloid formation;Animal Model;animal tissue;Antibodies;APP-PS1;Binding;Biological;Biological Assay;Biological Markers;brain tissue;Categories;Characteristics;Chemicals;Clinical;cohort;Data;Dependence;Deposition;Detection;detection assay;detection method;Development;Disease;Dyes;Evolution;Exhibits;experimental study;Fluorescence;Fluorescent Dyes;Fluorescent Probes;Future;Gentian Violet;Goals;Growth;Human;Image;imaging probe;improved;In Vitro;in vivo;in vivo imaging;in vivo monitoring;indexing;innovation;insight;Kinetics;Label;Laboratories;Link;mild cognitive impairment;misfolded protein;Monitor;monomer;Muramidase;Mus;Normal tissue morphology;novel;Oranges;Outcome;Pathogenicity;Pathologic;Pathology;Patients;Phase;Population;Positron-Emission Tomography;Proliferating;protein oligomer;Protocols documentation;Public Health;response;Role;Sampling;scaffold;screening;Series;Solid;Solvents;Specificity;Stains;success;Symptoms;tau aggregation;tau Proteins;Techniques;Testing;Thioflavin S;Tissues;Transgenic Mice;Transgenic Organisms;Validation

PROJECT_TITLE: Fluorescent probes for detection of misfolded protein oligomers in Alzheimer's Disease and related disorders


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Immunotherapy;Women's Health Research

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative As a result of limited treatment options, poor prognosis and the propensity to metastasize, basal-like breast cancer accounts for a disproportionate number of breast cancer-related deaths in U.S. women. Data from our lab shows that suppression of POLE differentially affects inflammatory gene expression of breast cancer cells of the basal type (BLBC) compared to luminal breast cancer cells, raising the question of what underlies these differences and how to leverage them therapeutically. This proposed work may illuminate a strategy for clinically targeting NF-? B and other pathways sensing genotoxic stress by the innate immune system in tumors primed to activate this pathway.

PI_NAMEs: GORODETSKY, ELIZABETH FRANCES (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Affect;Animals;Basal Cell Cancer;Biological Models;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;cancer cell;Cancer Etiology;cancer subtypes;cancer therapy;Cell Death;Cell Line;cell type;Cells;Cessation of life;Clinical;clinically relevant;CRISPR/Cas technology;CSF3 gene;cytokine;Data;Development;DNA Damage;DNA Polymerase II;DNA replication fork;Doxycycline;Environment;Exhibits;experience;Future;Gene Expression;Genotoxic Stress;Goals;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune signaling;Immune system;Immunofluorescence Immunologic;Immunological Models;Immunooncology;Immunotherapeutic agent;Immunotherapy;improved;Infiltration;Inflammatory;Inflammatory Response;Innate Immune System;Intercalating Agents;Interleukin-6;Intervention;Ionizing radiation;Knock-out;Luciferases;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Measures;Modality;Molecular;molecular subtypes;mortality;Mus;Mutagens;Neoplasm Metastasis;neoplastic cell;NF-kappa B;novel;Nude Mice;p65;Pathway interactions;Patient-Focused Outcomes;Pattern recognition receptor;Phenotype;Polymerase;Post-Translational Protein Processing;Production;Prognosis;programs;Proteomics;Regimen;RELA gene;Relapse;replication stress;Reporter;Resistance development;response;screening;senescence;Signal Transduction;small hairpin RNA;stem;Stimulator of Interferon Genes;targeted treatment;Therapeutic;therapeutically effective;Titrations;Topoisomerase Inhibitors;Transcript;transcription factor;transcriptomics;Treatment Protocols;treatment response;tumor;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells;Western Blotting;Woman;Women's mortality;Work;Xenograft procedure

PROJECT_TITLE: Activation of Inflammatory Responses Upon Replication Stress in Basal-Like Breast Cancer


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Natural Products;Neurosciences;Substance Misuse

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE: Medical and recreational Cannabis use has doubled in the last four years, and as the primary psychoactive compound, ∆9-Tetrahydrocannabinol (THC), becomes more prevalent it is critical to understand the various behavioral effects such as hypolocomotion. Using a cutting-edge endocannabinoid sensor, we have found that endogenous cannabinoid activity in the prelimbic cortex of the brain correlates with movement in THC treated animals. The goal of this proposal is to leverage cutting-edge approaches, while simultaneously enhancing neuroscience training in neuromodulation, to isolate the mechanisms by which THC modulates prelimbic cortical activity to mediate spontaneous movement in mice.

PI_NAMEs: ENGLISH, ANTHONY EDWARD (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Address;Affective;Age;Agonist;Animal Behavior;Animals;Behavior;behavior measurement;Behavioral;Biological;Brain;Calcium;Cannabinoids;Cannabis;Catalepsy;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;CNR1 gene;Computer Analysis;Contralateral;Data;differential expression;Disinhibition;Electrophysiology (science);endocannabinoid signaling;Endocannabinoids;Equilibrium;Event;excitatory neuron;executive function;experience;Fiber;Frequencies;gamma-Aminobutyric Acid;Glutamates;Goals;hippocampal pyramidal neuron;Human;In Situ Hybridization;in vivo;induced pluripotent stem cell;inhibitory neuron;Interneurons;Knock-out;Length;Locomotion;marijuana use;Measures;Mediating;Medical;Mentors;Messenger RNA;Modernization;Molecular;motor impairment;Movement;Mus;Neocortex;neocortical;neural circuit;Neurons;Neuropharmacology;neuroregulation;Neurosciences;novel;novel strategies;optogenetics;Patients;Pattern;pharmacologic;Pharmacology;Photometry;Physiological;Population;Prosencephalon;Psychotropic Drugs;receptor;receptor expression;Recreation;Research;Research Personnel;Resolution;response;Running;sensor;Series;Signal Transduction;skills;Slice;synthetic cannabinoid;System;Techniques;Technology;technology/technique;Testing;Tetrahydrocannabinol;Therapeutic;Time;Training;Viral

PROJECT_TITLE: Dissecting PFC Endocannabinoid-THC -regulated circuits in movement behavior


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE The goal of this project is to develop prognostic models of clinical outcomes that will incorporate baseline AR and non-AR ctDNA aberrations in men with mCRPC (A031201). In addition, we identify potential predictive biomarkers for overall survival benefit with combined abiraterone acetate and enzalutamide versus enzalutamide treatment alone from men with mCRPC enrolled in a phase III trial on the Alliance Trial A031201.

PI_NAMEs: ARMSTRONG, ANDREW J;DEHM, SCOTT M.;HALABI, SUSAN  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: abiraterone;Acceleration;Acetates;Alkaline Phosphatase;Androgen Antagonists;androgen biosynthesis;androgen independent prostate cancer;Androgen Receptor;Androgens;angiokines;AR gene;Biological Markers;Biology;Cancer Etiology;care delivery;Cessation of life;chemotherapy;circulating biomarkers;Clinic;Clinical;clinical phenotype;Clinical Research;Clinical Trials;Costs and Benefits;Data;design;Detection;Development;direct patient care;Disease;disease heterogeneity;DNA Markers;DNA Sequence Alteration;Eligibility Determination;Enrollment;enzalutamide;Future;Generations;Genetic;genomic aberrations;genomic predictors;Genomics;Goals;Heterogeneity;hormone therapy;improved;improved outcome;Individual;inhibitor;inhibitor therapy;insight;Kinetics;Lactate Dehydrogenase;Ligand Binding Domain;Malignant neoplasm of prostate;man;Measurement;Measures;Medical Genetics;men;men's group;Metastatic Prostate Cancer;Modeling;Mutation;Neoplasm Circulating Cells;novel;novel strategies;objective response rate;Outcome;patient variability;Patients;Pattern;Phase;phase III trial;Phenotype;Physicians;Plasma;Prediction of Response to Therapy;predictive marker;predictive modeling;Predictive Value;Prevalence;Prior Therapy;Prognosis;prognostic;prognostic model;prognostic value;radiological imaging;Research Design;Resistance;Resistance development;resistance mechanism;response;Risk;RNA Splicing;Serum;Speed;Symptoms;targeted treatment;taxane;Testing;therapy outcome;Toxic effect;Treatment outcome;tumor;tumor DNA;United States;Validation;Variant

PROJECT_TITLE: Clinical genomic predictive model of first line androgen receptor inhibitor therapy outcomes in men with mCRPC

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative: With no current therapeutics for cocaine use disorder, thousands of individuals are left vulnerable to relapse. This proposal seeks to identify the circuit-specific changes in neuronal activity and gene expression that drive cue-induced relapse to cocaine-seeking. These findings have the potential to identify novel therapeutic targets to treat cocaine relapse and cocaine use disorder.

PI_NAMEs: CAMPBELL, RIANNE  (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: Abstinence;Affect;Area;Behavior;Behavioral Model;Biological Assay;Biosensor;Calcium;Cannulas;career;Career Choice;Cells;Cocaine;cocaine craving;cocaine cue;Cocaine misuse;cocaine overdose;cocaine relapse;cocaine seeking;cocaine use;Cocaine use disorder;Cue-induced relapse;Cues;Data;design;Development;effective therapy;experimental study;Female;Fiber;Fiber Optics;Gene Expression;Genes;Genetic;Genetic Transcription;Globus Pallidus;Immunoprecipitation;Impairment;Implant;in vivo;Individual;Intravenous;Left;Link;male;Measures;Mediating;Messenger RNA;Methods;Modeling;Molecular;Mus;neural;neuromechanism;Neurons;new therapeutic target;novel;overdose death;Pathology;Pathway interactions;Pattern;Pharmaceutical Preparations;Photometry;Population;prevent;Process;Rattus;Relapse;Research;Research Personnel;response;Rewards;Ribosomes;RiboTag;Saline;Science;Self Administration;skill acquisition;skills;Stimulus;Synapses;Synaptic plasticity;Synaptic Transmission;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissues;Training;transcriptome sequencing;Ventral Tegmental Area;Virus

PROJECT_TITLE: Investigating the ventral pallidum-ventral tegmental area circuit in cocaine relapse


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: Project Narrative: We will estimate how well COVID-19 vaccines protect pregnant women and whether a vaccine given to the mother protects the baby from COVID-19. We will study pregnant women who do not get a COVID-19 vaccine so that we may propose data-driven ways to reach them and protect them from COVID- 19.

PI_NAMEs: ZERBO, OUSSENY  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Address;Affect;Age;Authorization documentation;Birth;Black race;California;Cessation of life;Characteristics;Clinical Trials;cost effective;COVID-19;COVID-19 pandemic;COVID-19 prevention;COVID-19 risk;COVID-19 vaccination;COVID-19 vaccine;Data;Development;Diphtheria-Tetanus-acellular Pertussis Vaccines;Effectiveness;effectiveness evaluation;efficacy trial;Electronic Health Record;evidence based guidelines;FDA Emergency Use Authorization;Future;General Population;Geography;Goals;health care service utilization;Hospitalization;improved;Infant;infant outcome;Influenza;Influenza vaccination;Integrated Health Care Systems;Intervention;Laboratories;Life;low socioeconomic status;maternal vaccination;Morbidity - disease rate;mortality;Mothers;novel;Observational Study;Outcome;pandemic disease;Pattern;Persons;Pertussis;Population Heterogeneity;Positioning Attribute;Pregnancy;Pregnant Women;Prenatal care;prevent;Public Health Practice;randomized, clinical trials;Recommendation;Research;Risk Factors;Risk Reduction;SARS-CoV-2 infection;Series;sociodemographic factors;sociodemographics;Time;unvaccinated;uptake;Vaccinated;Vaccination;vaccine acceptance;vaccine distribution;vaccine effectiveness;Vaccines;Woman

PROJECT_TITLE: COVID-19 Vaccine Effectiveness in Pregnant Women and their Infants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Approximately half of smokers engage in cigarette relighting (extinguishing, saving, and later relighting unfinished cigarettes) to save money, cut back to quit smoking, try to reduce harm, or due to lack of time to finish a cigarette. This behavior may increase health risks both due to compensatory smoking behavior and inadequate treatment and cessation attempts. This project will provide important new information about the extent, frequency, contextual factors, and potential dangers of the understudied behavior of relighting, with implications for both surveillance and treatment such as new assessment items that can be used to screen for relighting in population surveys and clinically and potentially inform clinicians in prescribing and delivering adequate-intensity behavioral and pharmacological smoking cessation treatments for the half of smokers who relight.

PI_NAMEs: HECKMAN, CAROLYN ;STEINBERG, MICHAEL B. (contact);STEPANOV, IRINA

PROGRAM_OFFICER_NAME: LAND, STEPHANIE R

PROJECT_TERMS: Abstinence;Address;Adult;Affect;American;Back;Behavior;Behavior Therapy;Behavioral;Carbon Monoxide;Carcinogens;Chronic Bronchitis;Cigarette;cigarette smoke;Cigarette Smoker;Clinic;Clinical;Compensation;contextual factors;cost;Data;Data Analyses;Dedications;Dependence;disenfranchised population;Disparity;Dose;Economics;Education;Environment;Epidemiology;Evaluation;Exhalation;experimental group;Exposure to;Formaldehyde;Foundations;Frequencies;Future;Harm Reduction;Health;Health Benefit;health disparity;Health Status;High Prevalence;high risk;Individual;International Agency for Research on Cancer;Intervention;Knowledge;Lead;Lighting;low socioeconomic status;Malignant neoplasm of lung;Measurement;Measures;Mental Health;Motivation;Nicotine;Nicotine Dependence;Outcome;Participant;Pattern;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Pilot Projects;Population;population survey;Prevalence;primary outcome;prospective;Provider;Public Health;Reporting;Research;response;Risk;Sampling;Science;Smoke;Smoker;Smoking;Smoking Behavior;smoking cessation;Smoking Cessation Intervention;smoking prevalence;Subgroup;success;Surveys;Time;Tobacco;tobacco control;Tobacco Dependence;tobacco exposure;Tobacco Industry;Tobacco Surveillance;tobacco toxicant;Tobacco Use Cessation;Tobacco-Associated Carcinogen;Toxic effect;toxicant;Toxicant exposure;treatment and outcome;treatment comparison;treatment program;treatment strategy

PROJECT_TITLE: Evaluating Cigarette Relighting Behavior: Prevalence, Correlates, Toxicant Exposure, and Implications for Cessation

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: EDINBURG

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

ORG_STATE: TX

PHR: NARRATIVE Autistic children might be misdiagnosed as having a language impairment or be at risk of having their language or communication challenges attributed to bilingualism, consequently delaying the attainability of appropriate services. This study seeks to understand the contribution of clinical and demographic predictors of language skills development in autistic school-aged children. The expected results will positively affect public health and educational systems by informing the standards for language assessments for bilingual Spanish–English–speaking autistic children.

PI_NAMEs: MONTIEL-NAVA, CECILIA  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Address;Affect;Age;Analysis of Variance;autism spectrum disorder;autism symptoms;autistic;autistic children;bilingualism;Characteristics;Child;Clinical;Communication difficulty;Communities;community based participatory research;comparison group;Competence;Comprehension;Control Groups;cultural competence;Data;design;Development;Diagnosis;Diagnostic;Documentation;Educational Status;Environment;Evaluation;experience;Exposure to;Family;Fostering;Foundations;Funding Mechanisms;Gender;Goals;health disparity;Health Services Accessibility;Health system;higher education;improved;informant;innovation;Institution;Intervention;Knowledge;Language;Language Development;language impairment;Linear Regressions;Linguistics;Low income;low socioeconomic status;Measures;Methods;Mission;Multivariate Analysis;Nursery Schools;Outcome;Parents;Participant;Pathway interactions;Pattern;peer;Perception;Performance;Population;Process;public education;Public Health;Recording of previous events;recruit;Reduce health disparities;Regression Analysis;Research;Research Project Grants;Risk;Risk Factors;Sampling;school district;School-Age Population;Semantics;Services;skill acquisition;skills;social;sociodemographics;Solid;Spanish/English;Strategic Planning;Symptoms;System;Testing;Translating

PROJECT_TITLE: Predictors of language skills in bilingual children with autism spectrum disorder (ASD)


NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Genetics;Microbiome;Nutrition;Obesity;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: The role of extrahepatic cells in the physiological effects of very low-carbohydrate, high-fat ketogenic diets remains poorly understood. Our Preliminary Results and the scientific literature provide strong support for the scientific premise of our hypothesis that diet-induced shifts in the host production of ketone bodies selectively inhibit the growth of gut bacteria leading to a decrease in immune cell activation and improved metabolic phenotypes. We will dissect these complex host-microbial interactions through the paired genetic manipulation of host and bacterial pathways, providing a critical step towards our long-term goal of harnessing the microbiome to treat metabolic disease.

PI_NAMEs: TURNBAUGH, PETER JAMES (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Actinobacteria class;Adipose tissue;Adult;Affect;Animal Model;Animals;Antimicrobial Effect;Area;Bacteria;Bacterial Genes;beta-Hydroxybutyrate;Bifidobacterium;Body Weight decreased;carbohydrate metabolism;Carbohydrates;Cells;Coenzyme A;Collection;Complex;Diet;diet-induced obesity;dietary restriction;Enteral;Enterocytes;Esterification;Esters;experimental study;Extrahepatic;Fatty acid glycerol esters;Future;Genes;Genetic;Genetic Determinism;genetic manipulation;global health;glucose tolerance;Gnotobiotic;Goals;Growth;gut bacteria;gut inflammation;gut microbiome;gut microbiota;Hepatocyte;High Fat Diet;host microbiome;host microbiota;host-microbe interactions;Human;human disease;human model;Immune;immune activation;Immune system;immunoregulation;improved;In Vitro;Inflammatory;innovation;Insulin Resistance;Intervention;Intestines;ketogenesis;ketogenic diet;Ketone Bodies;Ketones;Ketosis;Libraries;Lipids;Literature;liver metabolism;Macronutrients Nutrition;Mediating;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolic syndrome;metabolomics;Michigan;microbiome;microbiome research;mouse genetics;mouse model;Mus;Mutagenesis;novel;Obesity;Oral Administration;Pathway interactions;pharmacologic;Phenotype;Physiological;Positioning Attribute;prebiotics;Probiotics;Production;programs;Protocols documentation;Publishing;Research;Rodent Model;Role;screening;Series;Shapes;Source;Specificity;Structure;sugar;Testing;Tissues;tool;Transgenic Mice;Work

PROJECT_TITLE: Host-microbiome interactions shape the metabolic effects of ketogenic diets

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Nurses are the largest U.S. professional group, and nurse burnout and depression, causing some nurses to leave the profession, are a major threat to the healthcare system. Working on the front lines, they encounter situations that cause moral distress (or the inability to deliver what they believe is ethically appropriate care because of external constraints). Unaddressed moral distress can have lasting impacts on their personal and professional lives; to improve the healthcare system, we must ask nurses to describe their ethical challenges in order to modify factors that contribute to moral distress and boost their ethical confidence.

PI_NAMEs: ULRICH, CONNIE MARIE (contact)

PROGRAM_OFFICER_NAME: HAUGSTETTER, MONIKA

PROJECT_TITLE: Modeling How Moral Distress & Ethical Confidence Impact Nurses' Emotional & Physical Health and Safety Culture

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: ORTHOPEDICS

PHR: PROJECT NARRATIVE  Achilles tendon ruptures are common injuries that have long-term implications on patient function and activity levels. This proposal investigates the healing response of both muscle and tendon following an Achilles tendon rupture to identify the mechanisms responsible for compromised muscle quality and poor function. These findings will provide support decision making of both clinicians and patients and establish a research framework for developing and optimizing therapies for improving patient outcomes.

PI_NAMEs: BAXTER, JOSH  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: achilles tendon;Acute;Animal Model;Biological;Biomechanics;Biomedical Engineering;Biometry;career development;Clinical;clinical effect;clinical translation;Clinical Trials;clinically relevant;Continuing Education;Contracture;Controlled Clinical Trials;Data;Decision Making;Development;Devices;Doctor of Philosophy;dosage;Educational workshop;Environment;experience;experimental study;Feedback;Fiber;Flexor;follow-up;foot;Funding;Gastrocnemius Muscle;Goals;Grant;healing;Histology;Home;Human;Human Subject Research;Image;Immobilization;improved;Infiltration;Injury;Institution;Interdisciplinary Study;Intervention;Kinesiology;Laboratories;Laboratory Research;Lead;Length;Link;Literature;Measurement;Mechanics;Medical Imaging;Mentors;Modeling;Muscle;muscle physiology;Muscular Atrophy;muscular structure;Musculoskeletal;Musculoskeletal Diseases;novel;Operative Surgical Procedures;Orthopedics;Pathology;patient population;Patient-Focused Outcomes;Patients;Pennsylvania;post-doctoral training;preservation;Protocols documentation;Rattus;repaired;Research;research faculty;Research Personnel;response;responsible research conduct;Rest;Role;Rupture;Sarcomeres;Services;Skeletal Muscle;skills;soft tissue;Stretching;Structure;symposium;targeted treatment;Techniques;Tendon Injuries;tendon rupture;Tendon structure;Tendon Transfer;Testing;Tissues;Training;treatment optimization;treatment planning;Ultrasonography;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Modifying muscle remodeling following Achilles tendon ruptures

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: HG

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative What proteins bind to the genomic DNA in a cell and where they bind in the genomic sequence are fundamental questions to understanding cellular functions and disease mechanisms. The proposed research seek to develop molecular tools that can capture protein-DNA complexes in cells with high efficiency and specificity to facilitate the mechanistic studies of biological processes and diseases.

PI_NAMEs: CHEN, LIN  (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Address;adduct;Amines;Antibodies;Belief;Binding;Binding Proteins;Binding Sites;Biological Process;carbene;Cell Count;cell fixation;Cell Line;Cell Nucleus;Cell Physiology;Cells;Chemistry;ChIP-seq;chromatin immunoprecipitation;Complex;Complex Analysis;crosslink;Crosslinker;Data;data quality;Data Set;design;Diazomethane;Disease;disuccinimidyl glutarate;DNA;DNA Binding;DNA Binding Domain;DNA-Binding Proteins;DNA-protein crosslink;DNA-Protein Interaction;dosage;Effectiveness;Engineering;Epitopes;established cell line;Formaldehyde;functional group;GATA1 gene;Gene Expression;genetic regulatory protein;Genetic Transcription;Genome;genome-wide;genome-wide analysis;Genomic DNA;Genomics;Hela Cells;improved;In Situ;In Vitro;in vivo;intercalation;K-562;Lighting;Link;Maps;Masks;Methods;Modification;Molecular;Molecular Biology;Molecular Probes;Monitor;Morphologic artifacts;muscle enhancer factor-2A;Names;nitrene;Noise;novel;Nuclear;Nucleic Acids;Permeability;Photoaffinity Labels;Post-Translational Protein Processing;protein complex;protein crosslink;Proteins;Protocols documentation;Reaction;recruit;Reporting;Repression;Reproducibility;Research;RNA;sample fixation;Signal Transduction;Site;Source;Specificity;Surface;Techniques;Technology;Testing;Time;tool;transcription factor;Work

PROJECT_TITLE: Bi-functional photo-crosslinking (BFPX) for genome-wide study of protein-nucleic acid interactions

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Disability Research;Dissemination and Implementation Research;Mental Health;Neurodegenerative;Neurosciences;Rehabilitation

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is one of the leading causes of disability in older adults. Because pharmacological approaches do not seem to prevent or slow the disease, clinicians need non-pharmacological interventions that might help people with AD remain independent for as long as possible. This study aims to evaluate the effects of a new behavioral treatment for adults with mild cognitive impairment designed to promote independent living skills by explicitly teaching the use of strategies and tools to compensate for cognitive weaknesses.

PI_NAMEs: LANZI, ALYSSA MARIE (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Active Learning;Address;Adherence;Adult;Alzheimer's Disease;Alzheimer's disease related dementia;amnestic mild cognitive impairment;Award;Behavior;Behavior assessment;Behavior Therapy;behavioral clinical trial;Behavioral Model;Bypass;career development;Caring;Clinical;Clinical effectiveness;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive rehabilitation;cognitive system;cognitive task;cognitive testing;Cognitive Therapy;community setting;comparison control;Compensation;Conduct Clinical Trials;Control Groups;daily functioning;Delaware;Dementia;design;Development;Development Plans;disability;Discipline;Disease;Dissemination and Implementation;Doctor of Philosophy;Educational process of instructing;Effectiveness;efficacy evaluation;Enrollment;Evidence based intervention;experience;experimental group;Family member;Feedback;Florida;Focus Groups;Funding;Future;Goals;Health Professional;implementation research;improved;Independent Living;Individual;innovation;Intervention;Intervention Trial;Knowledge;Knowledge acquisition;Language;Learning;learning strategy;Life;Literature;Maintenance;Manuals;Memory;Mentors;Mentorship;mild cognitive impairment;Modernization;Modification;multidisciplinary;Neuropsychology;Nonpharmacologic Therapy;Occupational Therapist;Occupational Therapy;older adult;Outcome;Outcome Measure;participant enrollment;Pathologist;Patient Outcomes Assessments;Performance;person centered;Persons;pharmacologic;Phase I Clinical Trials;pilot trial;Population;Prediction of Response to Therapy;preservation;Prevalence;prevent;Procedures;Productivity;professor;programs;psychologic;Public Health;Quality of life;Quasi-experiment;Randomized;randomized trial;Randomized, Controlled Trials;Rehabilitation therapy;repaired;Research;Research Activity;Research Assistant;research study;restorative treatment;Self Efficacy;Short-Term Memory;skills;Societies;Specific qualifier value;Speech;Speech-Language Pathology;Structure;success;System;therapy development;tool;Training;treatment adherence;treatment comparison;treatment effect;treatment group;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Promoting Independence with Compensatory Cognitive Rehabilitation: A Pilot Clinical Trial for Early-Stage Alzheimer's Disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Immunotherapy;Rare Diseases

ORG_DEPT: GENETICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Head and neck squamous cell carcinoma (HNSCC) is a physically deforming and often fatal disease with limited treatment options. NSD1, a histone methyltransferase involved in epigenetic regulation of gene expression, is inactivated in ~15% of HNSCC. This project proposes to understand the mechanism by which NSD1 loss promotes the development of HNSCC, with a specific focus on the role of NSD1 in tumor immune escape.

PI_NAMEs: LU, CHAO  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Ablation;advanced disease;Affect;aggressive therapy;Biochemical;Biological Markers;cancer cell;Cell Line;Chromatin;Clinical;CRISPR/Cas technology;derepression;Development;Disease;disorder subtype;DNA;DNA Modification Methylases;DNMT3a;Elements;Epigenetic Process;epigenetic regulation;epigenetic silencing;epigenome;Event;EZH2 gene;FDA approved;Future;gain of function;Gene Expression Regulation;gene repression;Genes;Genetic;Genetically Engineered Mouse;genome-wide;Genomic Instability;Growth;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Histone H3;histone methyltransferase;Histones;humanized mouse;Imaging technology;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune Evasion;Immune system;Immune Targeting;Immunocompetent;Immunofluorescence Immunologic;immunogenicity;Immunologic Surveillance;Immunosuppression;Immunotherapy;in vivo;Incidence;Individual;Infiltration;inhibitor;Interferons;Knowledge;Leucocytic infiltrate;Link;loss of function;Mediating;Methylation;Minority;Modeling;Molecular;mouse model;multiplexed imaging;Mus;mutant;Mutation;Nature;Neoplasm Metastasis;novel;oncohistone;patient response;Patients;Pattern recognition receptor;pharmacologic;Prediction of Response to Therapy;predictive marker;recruit;Recurrence;Regulation;Relapse;Reporting;Resistance;response;Retrotransposon;Role;Sampling;Science;Signal Pathway;single-cell RNA sequencing;STAT1 gene;Survival Rate;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Tissue imaging;tumor;Tumor Escape;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-infiltrating immune cells;Work

PROJECT_TITLE: Epigenetic Regulation of Head and Neck Cancer Immune Evasion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Both of insulin receptor (IR) and type 1 insulin-like growth factor receptor (IGF1R) are receptor tyrosine kinases (RTK) that play essential roles in controlling glucose metabolism and cellular growth, and aberrant IR or IGF1R signaling causes a number of human diseases, including diabetes and cancers. Despite the functional importance, the exact ligand induced activation mechanism of IR and IGF1R are still unknown. In this project, we will study the structure and function of full-length receptors/ligands complex to reveal how ligands binding to the receptors lead to the receptor activation.

PI_NAMEs: BAI, XIAOCHEN  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Adopted;Affinity;Binding;Binding Sites;Biochemical;Biological Assay;Biophysics;blood glucose regulation;cell growth;Cell membrane;Cell Surface Receptors;Cellular Assay;Classification;Complex;Cryoelectron Microscopy;Data;design;Diabetes Mellitus;dimer;Dimerization;Disease;disulfide bond;Elements;Environment;Exhibits;Extracellular Domain;Family;flexibility;glucose metabolism;Goals;Growth Factor Receptors;human disease;IGF1 gene;IGF2 gene;improved;In Vitro;Insulin;Insulin Receptor;Insulin-Like Growth Factor Receptor;Insulin-Like-Growth Factor I Receptor;Kinetics;Lead;Length;Ligand Binding;Ligands;Link;Lipid Bilayers;Lipids;Malignant Neoplasms;Maps;Methods;migration;Modeling;Molecular Conformation;Mutagenesis;mutant;Mutation Analysis;novel;Outcome;Phosphorylation;Play;Positioning Attribute;Proliferating;Property;Protein Family;Proteins;Protomer;receptor;Receptor Activation;Receptor Protein-Tyrosine Kinases;Receptor Signaling;reconstitution;Resolution;response;Role;Series;Signal Transduction;Site;Source;Specificity;Structural Models;Structure;Techniques;Testing;therapeutic target;Transmembrane Domain;Visualization;Work

PROJECT_TITLE: Structural and Functional Analyses of the Full-length Insulin Receptor (IR) and Type 1 Insulin-like Growth Factor Receptor (IGF1R) in the Liganded Active State

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will evaluate implementation strategies for and effectiveness of navigator-delivered electronic patient-reported outcome home symptom monitoring and management (Home ePRO). Once the success of these strategies is demonstrated, there is potential for broad implementation of navigator-delivered Home ePRO to ultimately reduce patient symptom burden, minimize adverse outcomes associated with uncontrolled symptoms, and significantly advance the field's knowledge of optimal approaches to patient-reported outcome implementation. Thus, the proposed research is relevant to the NIH's mission with respect to reducing illness and disability.

PI_NAMEs: ROCQUE, GABRIELLE  (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Accident and Emergency department;Address;Administrator;Admission activity;Adult;Advanced Malignant Neoplasm;adverse outcome;African American population;Alabama;cancer care;Cancer Model;Cancer Patient;cancer survival;cancer therapy;Caring;chemotherapy;Client satisfaction;Clinical;Clinical Medicine;Collaborations;Consolidated Framework for Implementation Research;cost;Data;Data Sources;disability;Distress;Economically Deprived Population;Effectiveness;electronic patient reported outcomes;Electronics;Emergency department visit;evidence base;experience;Financial Support;functional status;Funding;Future;Goals;Health Care Rationing;health care service utilization;Health Services Research;Health system;Healthcare;Home;Hospitalization;Hospitals;Human Resources;hybrid type 2 design;implementation evaluation;implementation framework;implementation intervention;implementation outcomes;implementation science;implementation strategy;implementation trial;implementation/effectiveness;improved;Infrastructure;innovation;Institution;Intensive Care Units;Intervention;intervention delivery;Interview;Knowledge;Letters;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medical Care Team;Medicare;Mental Depression;Methodology;Minority;Mission;Modeling;Monitor;Nurses;Nursing Services;Oncology;Outcome;Outcomes Research;Patient Care;patient home care;patient navigator;Patient Outcomes Assessments;Patient Participation;patient population;Patients;payment;Penetrance;Penetration;Perception;Physicians;Population;population based;Positioning Attribute;Provider;provider adoption;Public Health;Quality of life;randomized trial;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Research Support;Resources;response;rural dwellers;scale up;Services;Site;socioeconomic disadvantage;standard of care;success;Surveys;Symptom Burden;symptom management;Symptoms;System;Technology;Testing;Time;treatment duration;United States National Institutes of Health;Universities;Vendor;Visit;Vulnerable Populations;week trial;Work

PROJECT_TITLE: Evaluating the implementation and impact of navigator-delivered ePRO home symptom monitoring and management

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Neurosciences;Prevention;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE Glioblastoma is the most common brain cancer and one of the deadliest. To date, immunotherapy has not prolonged the life of glioblastoma patients to the same extent as in other advanced cancers such as melanoma. In this proposal, we are going to conduct a clinical trial of a novel combination of immunotherapies for glioblastoma and then analyze tumor and blood samples from patients in the trial to advance our understanding of the immune system in brain tumors.

PI_NAMEs: HAFLER, DAVID A. (contact);OMURO, ANTONIO M

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Acceleration;Adult;Advanced Malignant Neoplasm;Aftercare;Alpha Cell;anti-CTLA4;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;Antibodies;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Automobile Driving;bench to bedside;Biological;Biological Markers;Blood;Blood specimen;blood treatment;Brain Neoplasms;cancer infiltrating T cells;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Central Nervous System;Central Nervous System Neoplasms;chemoradiation;Chronic;Clinical;Clinical Trials;Clonal Expansion;Clonality;Coculture Techniques;cohort;Combination immunotherapy;CTLA4 gene;Data;design;Development;Disabling;Disease;effector T cell;efficacy study;Environment;Evaluation;Excision;Exposure to;Frequencies;Functional disorder;Glioblastoma;Human;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immune System Diseases;Immunity;Immunofluorescence Immunologic;immunosuppressed;Immunotherapy;improved;In Vitro;in vitro Assay;in vivo;Infiltration;Inflammatory;Interferon Type II;Laboratories;Lead;Life;Ligands;Malignant neoplasm of brain;Malignant Neoplasms;Melanoma;Metastatic malignant neoplasm to brain;Modeling;Monoclonal Antibodies;Myeloid Cells;neoantigens;novel;Operative Surgical Procedures;participant enrollment;Pathway interactions;Patients;PD-1 blockade;Peripheral;Peripheral Blood Mononuclear Cell;permissiveness;Pharmaceutical Preparations;Phase;Phase 0/1 Clinical Trial;Phase 0/1 Trial;Placebos;Play;prevent;Primary Brain Neoplasms;Prior Therapy;Prognosis;Prognostic Factor;programmed cell death protein 1;Proliferating;Randomized;receptor;Recurrence;Recurrent disease;Recurrent tumor;Regulatory T-Lymphocyte;Resolution;response;Role;Safety;Sampling;Schedule;Seminal;Signal Transduction;single-cell RNA sequencing;Solid Neoplasm;Specimen;T cell infiltration;T-Cell Proliferation;T-Lymphocyte;Testing;Toxic effect;trait;transcriptomics;trial design;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Tumor-Derived;Validation;Work

PROJECT_TITLE: Targeting T cell dysfunction in glioblastoma: A proof-of-concept Phase 0/I trial of anti-TIGIT antibody AB154 in combination with anti-PD1 antibody AB122

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;HIV/AIDS;Infectious Diseases;Microbiome;Neurosciences

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project narrative Our prior research has shown that dysfunction of a specific nerve, called the vagus nerve, is associated with small intestinal bacterial overgrowth (SIBO), and that SIBO is associated and signs of inflammation in the blood of people living with HIV (PLWH). This research will explore pathways linking vagal dysfunction to inflammation in HIV, focusing on the gastrointestinal tract, and study whether a medication called pyridostigmine and stimulation of the vagus nerve are beneficial therapies.

PI_NAMEs: ROBINSON-PAPP, JESSICA  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Acetylcholine;Acetylcholinesterase Inhibitors;Affect;Age;antiretroviral therapy;Bacterial Translocation;Biological Markers;Blood;Breath Tests;capsule;cholinergic;Chronic;cohort;Collection;comorbidity;cytokine;Development;Disease Progression;Dose;Double-Blind Method;Eligibility Determination;follow-up;Functional disorder;Gastric Acid;gastrointestinal;gastrointestinal function;Gastrointestinal tract structure;Gastrointestinal Transit;Gender;Goals;Growth;gut microbiome;High Prevalence;HIV;HIV Infections;HIV Seronegativity;Hydrogen;Hypochlorhydria;Immune;immune function;Individual;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Interleukin-6;Intervention;Link;Logistic Regressions;Macrophage;Macrophage Activation;Measurement;Mediating;Medical;Methane;Modification;Morbidity - disease rate;mortality;Motility;motility disorder;Mucous Membrane;Nerve;Neuropathy;open label;Oral;Participant;Pathologic;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phase;Pilot Projects;Placebos;Procedures;Process;Production;Proxy;pyridostigmine;Randomized;recruit;Research;Rodent Model;sample collection;Signal Transduction;Small Intestines;Stimulus;stool sample;Swab;Testing;Time;TNF gene;vagus nerve stimulation;Vagus nerve structure;Viral;wireless;Work

PROJECT_TITLE: Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: Blast-mediated traumatic brain injury (TBI) is a leading cause of injury for Veterans. Blast TBI triggers an activation of the immune system, generation of auto-antibodies, as well as CNS infiltration of circulating immune cells. Our central hypothesis is that blast-mediated traumatic brain injury activates cellular and humoral immune responses that lead to increased chronic neurodegeneration after TBI. The overall goal of this study is to determine which components of this response are necessary and sufficient to cause neuronal loss and dysfunction after blast-mediated TBI. We will also determine if these responses can be modulated with currently approved medications.

PI_NAMEs: HARPER, MATTHEW M. (contact);KUEHN, MARKUS H.

PROJECT_TERMS: Accounting;Acute;Adaptive Immune System;adoptive B cell transfer;Adoptive Transfer;Affect;American;Animals;Astrocytes;Autoantibodies;B-Lymphocytes;blast exposure;Blast Injuries;Blindness;Brain;Cause of Death;Cell Death;Cell Separation;Cells;Cellular Immunity;Central Nervous System;Cessation of life;Chronic;Clinical;clinically relevant;Complement;Complement Activation;Complement Membrane Attack Complex;Data;Defect;Detection;Devices;Drug Utilization;experience;experimental study;Exposure to;Eye;Gene Expression;Gene Modified;Generations;Goals;Health;Humoral Immunities;Immune;immune activation;Immune response;Immune system;improved;improved outcome;Individual;Infiltration;Inflammation;inhibitor;Injury;Knowledge;Mediating;Microglia;microorganism;Mus;Nerve Degeneration;neuroinflammation;neuron loss;Neuronal Dysfunction;Neurons;novel therapeutic intervention;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;prevent;Process;Quality of life;receptor;response;Retina;Role;service member;Signal Transduction;Splenocyte;Structure;T-Lymphocyte;Testing;Therapeutic Intervention;Time;Tissues;Translating;Transplantation;Traumatic Brain Injury;Veterans;Vision;Wild Type Mouse

PROJECT_TITLE: Evaluating the interaction of the immune system and inflammation on the progression of blast-mediatedneurodegeneration.

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Overall Narrative The principal goal of the University of Pittsburgh Alzheimer’s Disease Research Center (PITT-ADRC) is to perform and promote research that increases our understanding of the etiology and pathogenesis of Alzheimer’s disease (AD) and related dementias in order to ultimately advance new therapies. The PITT- ADRC provides the infrastructure to investigate the mechanisms underlying cognitive and behavioral symptoms, and to develop strategies for effective early diagnoses and treatments of AD. We will accomplish this goal with our own research, involving investigators at the University of Pittsburgh and nearby institutions in clinical and basic research, and with collaborations with other national and international centers of excellence, in an environment that supports innovative research and enhances training and educational opportunities for patients, caregivers, students, scientists and clinicians

PI_NAMEs: LOPEZ, OSCAR L. (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Address;Adult;Advocacy;Altruism;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Area;Awareness;Basic Science;Behavioral Symptoms;Biological;Biological Markers;Biology;Blood;Brain;career;Caregivers;Caring;Clinic;Clinical;Clinical assessments;Clinical Course of Disease;Clinical Data;Clinical Research;Cognition;Cognition Disorders;Cognitive;cohort;Collaborations;Communication;Communities;Data;Data Collection;data management;Databases;Dedications;Dementia;design;Development;disease phenotype;Early Diagnosis;Early treatment;Education;education research;effective therapy;efficacious treatment;Environment;Etiology;Evaluation;Evolution;Faculty;Family;Foundations;Functional disorder;Funding;Genetic;genetic risk factor;Goals;Grant;health care delivery;Healthcare;Heterogeneity;Human Resources;Image;Imaging technology;improved;Individual;Infrastructure;innovation;insight;Institution;interdisciplinary approach;International;international center;Investments;Leadership;member;Methodology;Methods;mild cognitive impairment;Motivation;MRI Scans;multidisciplinary;Natural History;Nerve Degeneration;Neurobehavioral Manifestations;neurogenetics;neuroimaging;neuropathology;neuropsychiatry;novel;novel therapeutics;Outcome;outreach;outreach program;Participant;Pathogenesis;Pathologic;Pathologic Processes;Patient Care;Patients;Pharmaceutical Preparations;Physicians;Positron-Emission Tomography;Process;Productivity;programs;Protocols documentation;Psychoses;Public Health;Qualifying;recruit;Research;Research Personnel;research study;Risk Factors;Role;Sampling;Scientist;Solid;Standardization;Students;Symptoms;Testing;Tracer;Training;Training and Education;Training Programs;Universities;Validation

PROJECT_TITLE: Alzheimer's Disease Research Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

PROJECT_TERMS: Administrator;Advisory Committees;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Animals;Area;Biological;Biological Markers;Biology;Biology of Aging;Blood;blood-based biomarker;Budgets;Caregiver support;Caring;cerebral amyloidosis;Chairperson;Clinical;Clinical Drug Development;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;Complex;Critiques;Data;data exchange;data management;data repository;Data Science;Data Set;data sharing;data storage site;Databases;Dementia;Dementia with Lewy Bodies;design;Detection;Development;Developmental Process;Discipline;Disease;DNA;drug discovery;Education;education research;Ensure;Epidemiology;Expenditure;Faculty;Fostering;Functional disorder;Funding;Genetic;Genetic Diseases;Geriatrics;Goals;Grant;Health care facility;Health Sciences;human subject;Image;improved;Inflammation;Infrastructure;Inherited;interest;International;interoperability;Leadership;Ligands;Link;Maintenance;medical schools;medically underserved;meetings;minimally invasive;minority communities;Monitor;Multicenter Studies;multidisciplinary;National Institute on Aging;Neurobiology;neurogenetics;neuroimaging;Neurology;neuropathology;Neurosciences;novel;operation;organizational structure;outreach;Pathologic;peripheral blood;Pharmaceutical Preparations;Pharmacologic Substance;Philanthropic Fund;Physiology;Pilot Projects;Policies;Positron-Emission Tomography;Postdoctoral Fellow;pre-clinical;pre-doctoral;prevent;programs;Psychiatry;public-private partnership;Recommendation;recruit;Regulation;repository;Reproducibility;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;research study;Resources;Sampling;Schedule;Schools;statistics;Structure;Supervision;Synapses;System;Systems Biology;tau Proteins;Technology;Testing;Tissues;Training;Training Programs;underserved community;Universities;usability;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: SWEET, ROBERT A (contact)

PROJECT_TERMS: Acceleration;Achievement;Age;Agreement;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;amyloid imaging;Autopsy;Biological;Biological Markers;biomarker evaluation;Blood specimen;Brain;Brain imaging;Classification;Clinical;Clinical Data;Clinical Services;Clinical Trials;cognitive testing;cohort;Collaborations;Collection;Complex;Consent;Data;data management;Dementia;Development;Diagnosis;DNA;Education;Enrollment;Evaluation;flexibility;follow-up;Frontotemporal Lobar Degenerations;Funding;Genetic;genome wide association study;Goals;Impaired cognition;Impairment;Individual;informant;International;Intervention;Investigation;Knowledge;Lead;Leadership;Measures;meetings;mild cognitive impairment;Minority Recruitment;National Institute on Alcohol Abuse and Alcoholism;Natural History;Nerve Degeneration;neurogenetics;neuroimaging;neuropathology;neuropsychiatric symptom;neuropsychiatry;next generation;Normalcy;outreach;Parkinsonian Disorders;Participant;participant enrollment;Patients;performance tests;Plasma;Population;pre-clinical;Prevention;Procedures;Productivity;psychiatric comorbidity;Psychoses;Recording of previous events;recruit;referral services;repository;Research;Research Personnel;Research Project Grants;research study;Research Support;Resources;Role;Sampling;tau Proteins;Testing;Tissues;Training;trial readiness;Universities;Visit

PROJECT_TITLE: Clinical Core


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Infectious Diseases;Nutrition

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative In this proposal we will investigate the rerouting of the lipid synthesis pathways upon enterovirus infections. Our data support a model that diverse enteroviruses target the same cellular factors to induce upregulation of membrane synthesis needed for the protection of their replication sites. Understanding the mechanisms of this hostile takeover of the cellular lipid synthesis will reveal targets for the development of a new generation of broad-spectrum anti-viral therapeutics.

PI_NAMEs: BELOV, GEORGE A. (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acyl Coenzyme A;airway epithelium;Anti-viral Agents;Anti-viral Response;Biochemical;Biological Assay;Biotinylation;Cell Culture Techniques;Cell Differentiation process;Cell Line;Cells;Cellular biology;Cholesterol Esters;Coenzyme A;Coenzyme A Ligases;Complex;cytokine;Data;Development;Diglycerides;Double-Stranded RNA;drug development;Drug Targeting;effective intervention;Enteral;Enterocytes;Enterovirus;Enterovirus 71;Enterovirus Infections;Environment;Epithelium;Esterification;Eukaryota;fatty acid metabolism;FDA approved;Generations;Genes;Homeostasis;Human poliovirus;Hydrolysis;Infection;innovation;International;knockout gene;Knowledge;Licensing;Life Cycle Stages;Ligase;Lipase;lipid metabolism;Lipid Mobilization;Lipid Peroxides;Lipid Synthesis Pathway;Lipids;Lipolysis;long chain fatty acid;Measures;Membrane;membrane synthesis;Metabolic Pathway;Metabolism;Methods;Microscopy;Modeling;Monitor;mutant;Natural Immunity;Organelles;Pathway interactions;Peroxidases;Pharmaceutical Preparations;Phenotype;Phospholipids;Polyunsaturated Fatty Acids;protein protein interaction;Proteins;Proteome;Proteomics;Publishing;Reaction;recruit;Research;Resistance;Resistance development;Resources;respiratory;RNA Viruses;Role;Route;sensor;Signal Pathway;Signal Transduction;Site;Speed;Structure;System;therapy development;transcriptome sequencing;Triglycerides;Up-Regulation;Vaccines;Viral;Viral Physiology;Viral Proteins;virology;Virus Replication

PROJECT_TITLE: Infection-specific lipid metabolism as a target to control enterovirus infections


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Aspergillus fumigatus is a fungus that causes hard to treat, often fatal aspergillosis diseases. The fungus grows as invasive filaments in infected patients. Here we will identify the fungal and host factors that favor fungal growth, with the goal to target these factors for therapeutic treatment of fungal infections.

PI_NAMEs: KELLER, NANCY P (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Affect;analog;antagonist;anti-fungal agents;Aspergillosis;Aspergillus;Aspergillus fumigatus;Automobile Driving;Biochemical;Biological Assay;Calcium;Communication;Data;Death Rate;defense response;design;Development;Disease;Disease Progression;Equilibrium;Family;Filament;Foundations;fungus;Future;G-Protein-Coupled Receptors;Gene Fusion;Genes;Genetic Transcription;Goals;Growth;Host Defense;human disease;Immune response;Immunocompromised Host;improved;In Vitro;in vivo;insight;Integration Host Factors;Kinetics;Knowledge;Language;Leukocytes;Ligands;Lipids;Macrophage;Mediating;microdevice;migration;Modeling;Molecular;mouse model;Mus;mutant;Mycoses;neutrophil;novel strategies;Optics;Oxygenases;Paracrine Communication;pathogen;Pathway interactions;Patients;Pattern;Penetration;Phagocytes;Pharmacologic Substance;Positioning Attribute;Predisposition;Process;Prostaglandin-Endoperoxide Synthase;receptor;Regulation;Reporter;Reporter Genes;response;Role;Series;Severities;Signal Pathway;Signal Transduction;small molecule;small molecule inhibitor;System;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Tissues;transcription factor;transcriptome;transcriptome sequencing;Virulence;Visual;With laterality;Work;Zebrafish

PROJECT_TITLE: Bidirectional paracrine signaling in the establishment of invasive aspergillosis

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Genetics;Prevention;Skin Cancer

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: UV-induced clonogenic mutations (CMs) can be used to evaluate an individual's overall sun exposure and the status of sun-induced genotoxicity in the skin which can profoundly impact how we diagnosis and treat early stage skin cancer. CMS can be used to evaluate therapeutic response to field treatments for skin cancer. CMS can be used to rapidly evaluate strategies for the prevention of skin cancer, such as the genoprotective efficacy of sunscreens or an individual's adherence to sunscreen application.

PI_NAMEs: PARAGH, GYORGY ;WEI, LEI  (contact)

PROGRAM_OFFICER_NAME: WANG, WENDY

PROJECT_TERMS: Adherence;Affect;aged;Anatomy;Area;Autopsy;Biological Markers;biomarker identification;biomarker panel;cancer care;Cancer Patient;cancer prevention;cancer risk;care outcomes;Cells;Chronic;Clinic;Clinical;Clinical Trials;clinically relevant;cohort;computerized tools;Data;Data Set;Detection;Development;Diagnosis;DNA;DNA Damage;dosage;Effectiveness;effectiveness evaluation;efficacy evaluation;Epidermis;Erythema;Evolution;Feedback;Future;Genes;genetic variant;Genomic DNA;Genomic Segment;Genomics;genotoxicity;Growth;high dimensionality;Human;improved;indexing;Individual;Intervention;irradiation;Kinetics;Knowledge;Lesion;Life;machine learning model;Malignant Neoplasms;Measurement;Measures;Methods;Modeling;mouse model;Mus;Mutagenesis;Mutate;Mutation;Normal tissue morphology;NOTCH1 gene;Oncology;Patient risk;Patients;Pattern;Photography;photoprotection;Play;pre-clinical;predictive panel;premalignant;prevent;Prevention;Prevention approach;Prevention strategy;Preventive measure;Preventive treatment;Process;Recording of previous events;Redness;research clinical testing;Resolution;Risk;Role;Sampling;Signal Transduction;Skin;Skin Cancer;skin cancer prevention;skin damage;Skin Squamous Cell;skin squamous cell carcinoma;Somatic Mutation;standard of care;sun damage;Sun Exposure;sun protection;Sun protection factor;Sunburn;sunlight-induced;Sunscreening Agents;targeted sequencing;Technology;Testing;Textiles;therapy design;Time;TP53 gene;Training;training data;treatment response;treatment strategy;tumor;Ultraviolet B Radiation;Ultraviolet Rays;UV carcinogenesis;UV induced;UV Radiation Exposure;UVB induced;Validation;Work

PROJECT_TITLE: Advancing skin cancer prevention by tackling UV-induced clonogenic mutations

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: BELLE, STEVEN H. (contact)

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Alzheimer's disease risk;analytical method;Ancillary Study;Area;Authorization documentation;Biological Markers;Biology;career;Caregivers;Clinical;Clinical Research;cohort;Collaborations;Communication;computerized;Consultations;Data;Data Analyses;Data Collection;data management;Data Protection;data registry;Data Reporting;Data Set;data sharing;database design;Database Management Systems;database query;database structure;Databases;Dementia;Development;Disease;Education;effective therapy;Epidemiology;Etiology;experience;Faculty;Fostering;Goals;Health Personnel;Human Resources;innovation;Interdisciplinary Study;interest;International;Leadership;Maintenance;Measures;meetings;member;Mentors;Methodology;Mission;Modeling;neurogenetics;neuroimaging;neuropathology;neuropsychiatry;Neuropsychology;next generation;Paper;Participant;Pathogenesis;Patients;Persons;Pharmaceutical Preparations;Prevention;Public Health;Quality Control;recruit;Registries;Reporting;Research;Research Design;Research Personnel;Role;Schedule;statistics;Symptoms;System;Tablet Computer;Training;Training and Education;Training Programs;Universities;user-friendly;web site;Work;working group

PROJECT_TITLE: Data Management and Statistical Core


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Gay and bisexual youth make up 80% of all new HIV infections among adolescents ages 14-19 in the United States, yet interventions to improve sexual health outcomes in these youth are extremely limited. Our team has developed an intervention to reduce HIV risk for gay and bisexual youth by working with their parents to improve the ways parents communicate with their sons about sexual health. We propose to deliver our intervention to parents of gay and bisexual teens ages 14-19 and to test whether it helps their sons by reducing sexual risks and increasing HIV testing.

PI_NAMEs: HUEBNER, DAVID M (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: active control;Adolescence;Adolescent;adolescent men who have sex with men;adolescent sexual health;Age;AIDS prevention;Anus;arm;Bisexual;Child;Child Rearing;Communication;condoms;Disparity;Educational process of instructing;effective intervention;efficacy testing;Epidemic;ethnic diversity;ethnic minority;Exclusion;Film;Frequencies;Funding;Gays;Goals;healthy sexuality;Heterosexuals;high risk;HIV;HIV Infections;HIV risk;Human immunodeficiency virus test;improved;Incidence;Instruction;Intervention;intervention effect;Mediating;Mediator;men of color;men who have sex with men;Methods;Modeling;Older Population;online intervention;optimism;Outcome;parenting intervention;Parents;Play;Politics;Population;post intervention;pre-exposure prophylaxis;primary outcome;racial diversity;racial minority;Randomized;Randomized, Controlled Trials;Readiness;recruit;Reporting;Research;Resources;Risk;Role;Sampling;Schools;sex;Sex Education;Sexual Health;sexual risk reduction;Sexuality;Shapes;skills;Son;success;Teenagers;Testing;therapy design;Time;treatment arm;United States;United States National Institutes of Health;Vagina;virtual;Work;young men who have sex with men;Youth

PROJECT_TITLE: RCT of a parent-focused intervention to reduce HIV risk in adolescent MSM

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: KOFLER, JULIA K (contact)

PROJECT_TERMS: Access to Information;aging related;Algorithms;alpha synuclein;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;amyloid imaging;Area;Autopsy;Biological Markers;Brain;brain tissue;Classification;Clinical;clinical diagnosis;clinical phenotype;Cognitive;cohort;Collaborations;Communities;comorbidity;computational pipelines;Consensus;Data;data management;data sharing;Databases;Detection;Diagnosis;Diagnostic;diagnostic criteria;digital;digital imaging;Disease;Education;education research;Educational process of instructing;endophenotype;Evaluation;Family;Feedback;Fibroblasts;Frontotemporal Lobar Degenerations;Genetic;Genetic Polymorphism;Harvest;histological image;human tissue;Image;Image Analysis;imaging agent;imaging approach;imaging biomarker;imaging study;Imaging technology;improved;in vivo;instrumentation;interest;Joints;Knowledge;Laboratories;Liquid substance;Measures;Medical Students;Mentors;Microscopy;mild cognitive impairment;Mission;Molecular;MRI Scans;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;neuroimaging;neuroinflammation;neuropathology;novel;Participant;Pathologic;Pathology;personalized diagnostics;Phenotype;Positron-Emission Tomography;Process;protein TDP-43;Protocols documentation;psychiatric comorbidity;Psychoses;Recommendation;Recording of previous events;repository;Research;Research Personnel;Research Project Grants;research study;resilience;Resources;Role;Scanning;Secure;skills;Slice;statistics;Systems Analysis;tau Proteins;Technical Expertise;Technology;therapeutic target;Time;Tissue Banks;Tissue Sample;Tissues;tool;treatment response;Triage;United States National Institutes of Health;Universities;Update;Variant;Vascular Diseases;web app;whole slide imaging

PROJECT_TITLE: Neuropathology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE While several research studies have demonstrated the positive impact of protective factors in Alzheimer's disease, this knowledge is yet to be translated into feasible dementia prevention trials. Understanding fundamental mechanisms through which important protective factors alter Alzheimer's disease trajectories is crucial to facilitate bench-to-bedside translation. In this proposal, we provide a theoretical framework to discover mechanisms that help prevent Alzheimer's disease pathologies or cope without cognitive symptoms even with Alzheimer's disease pathologies.

PI_NAMEs: VEMURI, PRASHANTHI  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Accounting;Address;Age;Age Factors;aged;Aging;aging process;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Anterior;Area;Behavior;bench-to-bedside translation;Biological;Biological Markers;Blood Pressure;Blood Vessels;Body mass index;Brain;brain health;Cardiovascular system;Cerebrovascular Disorders;Clinic;Clinical;Cognition;Cognitive;Cognitive aging;cohort;Complex;coping;Corpus Callosum;Data;Dementia;density;deprivation;design;Diffusion Magnetic Resonance Imaging;disability;Education;entorhinal cortex;Epidemiology;Evaluation;Genetic;Health;health literacy;Hemorrhage;Heterogeneity;Image;imaging biomarker;Impaired cognition;improved;indexing;Individual;Individual Adjustment;individual variation;Infarction;Infrastructure;Intervention;Knowledge;Lipids;machine learning method;Magnetic Resonance Imaging;Maps;Measurement;Measures;Medical Record Linkage;Metabolic;Methods;microsystems;Modeling;multimodality;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;Neurites;Neurobehavioral Manifestations;Nomenclature;Occupations;Pathologic Processes;Pathway interactions;Peer Review;perceived stress;Physical activity;Plasma;polygenic risk score;Population;population based;Positron-Emission Tomography;Predictive Factor;predictive marker;prevent;Prevention;Prevention strategy;Prevention trial;primary care visit;promote resilience;protective factors;Proteins;Publications;Research;research study;resilience;resilience biomarker;Resistance;resistance mechanism;Resolution;Risk Factors;Rural;Scanning;sex;Sleep;Smoking;social health determinants;Social Identification;Social support;success;System;tau aggregation;tau Proteins;Testing;therapeutically effective;Thick;Translating;White Matter Hyperintensity

PROJECT_TITLE: Investigating Resistance and Resilience Mechanisms in Alzheimer’s Disease


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: Pneumonia is a leading cause of morbidity and death, with no improvement in pneumonia-associated mortality rates since the 1950s. Because of rising antibiotic resistance in bacteria and significant limitations in the accuracy of diagnostic tests for pneumonia, many patients receive antibiotic treatment that is either ineffective against the bacteria causing their pneumonia or entirely unnecessary – while suspected pneumonia drives 49-60% of antibiotic prescribing in the United States, 30-60% of these prescriptions are ultimately unnecessary or inappropriate. We will further develop a rapid breath test for the diagnosis of bacterial pneumonia and early determination of whether the bacteria is susceptible to the antibiotic being used – this would allow patients with bacterial pneumonia to be identified earlier and more accurately than currently possible, improving clinical outcomes and reducing unnecessary antibiotic use.

PI_NAMEs: KOO, SOPHIA  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Accounting;Acute respiratory infection;Address;Anti-microbial susceptibility;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;automated algorithm;Bacteria;Bacterial Infections;Bacterial Pneumonia;bacterial resistance;Biological Assay;Biometry;Blood Circulation;Breath Tests;Cessation of life;Clinical;Collaborations;Combined Antibiotics;Communities;Death Rate;Detection;Development;Devices;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Equipment;diagnostic platform;Diagnostic Procedure;Diagnostic tests;diagnostic tool;Early identification;effective therapy;Engineering;Enterobacter cloacae;Escherichia coli;Etiology;Fingerprint;Gas Chromatography;Gastrointestinal tract structure;Hospitals;Hour;improved;in vivo;Industry Collaboration;Infection;Klebsiella pneumoniae;Laboratories;Lung;Metabolic;Microbe;microbial;microbial signature;miniaturize;Morbidity - disease rate;mouse model;Mycoses;novel;Onset of illness;Organism;Outcome;pathogen;pathogenic bacteria;Patients;Phenotype;Pneumonia;pneumonia treatment;point-of-care diagnosis;portability;Predisposition;pressure;Prevalence;Pseudomonas aeruginosa;Rapid diagnostics;response;Sensitivity and Specificity;Spectrometry;Staphylococcus aureus;Symptoms;Syndrome;tandem mass spectrometry;Test Result;Time;United States;Urinary tract infection;Ventilator;Viral Pneumonia;Volatilization;Work

PROJECT_TITLE: Rapid, Breath Volatile Metabolite-Based Diagnosis, Species Identification, and Antibiotic Resistance Profiling in Bacterial Pneumonia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_STATE: PA

PI_NAMEs: LINGLER, JENNIFER HAGERTY (contact)

PROJECT_TERMS: Address;Adopted;African American;African American population;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Ancillary Study;Area;Biological Markers;Black race;Caring;Characteristics;Classification;Clinic;Clinical;clinical care;clinical center;clinical training;Clinical Trials;cohort;Communities;community engagement;community organizations;Community Outreach;Continuing Education;Databases;Dementia;design;Diagnosis;digital;Discipline;Disclosure;Education;Education and Outreach;Effectiveness;Elderly;Elements;Evaluation;Event;Evidence based treatment;expectation;Faculty;Feedback;Fostering;Funding;Future;Goals;Health Professional;Health Sciences;health training;Impaired cognition;improved;Individual;innovation;Institution;Knowledge;Leadership;lectures;member;Methods;mild cognitive impairment;Monitor;Nature;Needs Assessment;Neighborhoods;neurogenetics;neuroimaging;Nursing Faculty;older adult;outreach;outreach program;Participant;Pathologic;Pathology;Periodicals;Persons;Population;Prevalence;Printing;Professional Practice;programs;protocol development;Provider;Public Health;recruit;Recruitment Activity;Registries;Research;Research Personnel;Research Training;Resources;response;retention rate;Risk;Rotation;satisfaction;Series;service organization;Site;Social Work;Students;success;Surveys;Training;Training Activity;Translating;United States Health Resources and Services Administration;Universities;Update;Vision

PROJECT_TITLE: Outreach, Recruitment and Engagement Core