ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Rheumatoid Arthritis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Periodontitis is a prevalent oral inflammatory disease that is independently associated with systemic disorders (comorbidities). This project investigates the hypothesis that inflammatory memory in bone marrow progenitor cells, which give rise to innate white blood cells, underlies the comorbid connection between periodontitis and systemic inflammatory diseases, such as rheumatoid arthritis. If confirmed, this knowledge will provide a platform for novel therapeutic interventions targeting inflammatory comorbidities through a holistic approach.

PI_NAMEs: HAJISHENGALLIS, GEORGIOS  (contact)

PROJECT_TERMS: Address;Affect;Arthritis;Bone Marrow;Bone Marrow Cells;Bone Marrow Transplantation;Cardiovascular Diseases;Cell Separation;Cells;Chromatin;Chronic;Chronic Disease;chronic inflammatory disease;collagen antibody induced arthritis;comorbidity;congenic;cytokine;Data;design;Development;Disease;Epidemiology;Epigenetic Process;experimental study;Future;Gene Expression;Hematopoietic stem cells;holistic approach;Immune;Immunologic Memory;Infection;Inflammation;Inflammatory;Inflammatory Arthritis;inflammatory bone loss;insight;Interleukin-1 beta;Interleukin-1 Receptors;Investigation;Knowledge;Leukocytes;Ligature;Long-Term Effects;Mediating;Memory;Modification;Mus;Myelogenous;Myeloid Cells;Myelopoiesis;Natural Immunity;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Oral;Periodontal Diseases;Periodontitis;Peripheral;pharmacologic;Phenotype;Pre-Clinical Model;Predisposition;Procedures;Production;progenitor;Proliferating;PTPRC gene;Readiness;Rheumatoid Arthritis;Role;Seminal;Signal Transduction;single cell ATAC-seq;stem cells;Stimulus;Study models;System;Systemic disease;systemic inflammatory response;Tamoxifen;Testing;therapeutic target;Training;transcriptomics;transmission process;Transplantation

PROJECT_TITLE: Trained innate immunity and periodontitis-associated comorbidities

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: MD

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Pediatric;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Sleep Research;Social Determinants of Health

ORG_CITY: COLUMBUS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative  Tonsillectomy, with or without adenoidectomy, is a very common pediatric surgical procedure and an effective treatment for both obstructive sleep disordered breathing and severe recurrent tonsillitis. There is significant unwarranted variation in tonsillectomy use across racial/ethnic groups and geographic regions in the United States. This project will identify and quantify the impacts of factors acting across multiple levels and domains on racial/ethnic and geographic differences in pediatric tonsillectomy use and will thereby inform the development and targeting of interventions to improve the appropriateness of care of children with obstructive sleep disordered breathing or recurrent tonsillitis.

PI_NAMEs: CHAVEZ, LAURA  (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: accountable care organization;Adenoidectomy;Adult;Affect;Automobile Driving;Behavior;Black race;Caregivers;Caring;Child;Child Care;Childhood;Communities;community-level factor;Consultations;cost;Data;Decision Making;Development;Educational Materials;effective therapy;Elective Surgical Procedures;Equity;ethnic difference;Ethnic Origin;Ethnic Population;Evaluation;expectation;experience;Family;Future;geographic difference;Geographic Locations;Geography;Guidelines;health care service utilization;Health Personnel;Hispanic;improved;Infection;Intervention;Interview;Investigation;Knowledge;Medicaid;medical specialties;Methods;National Institute on Minority Health and Health Disparities;NIH Program Announcements;Obstructive Sleep Apnea;Only Child;Operative Surgical Procedures;Otolaryngologist;Patients;Pediatric Surgical Procedures;Pharyngeal structure;Population;preference;primary care practice;primary care provider;Procedures;Process;Professional Organizations;Provider;Quality of life;Race;racial difference;racial population;Recommendation;Recurrence;Research;Resolution;response;Rural;rural area;rurality;Sampling;shared decision making;Sleep Apnea Syndromes;sociodemographics;Socioeconomic Status;Surgeon;surgical disparities;Symptoms;Time;Tonsil;Tonsillectomy;Tonsillitis;tool;Trust;United Kingdom;United States;Variant

PROJECT_TITLE: Racial/ethnic and geographic differences in pediatric tonsillectomy use: a multilevel investigation

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Nutrition;Physical Activity;Prevention

ORG_CITY: OMAHA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE The proposed studies will determine the mechanisms for beneficial influences of regular physical activity on brain and heart. We will identify protective factors released from muscle during exercise that can travel to these two vital organs to restore central autonomic function in chronic heart failure and protect the heart following an acute reduction in blood flow.

PI_NAMEs: GAO, LIE  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acute;Address;antioxidant enzyme;Antioxidants;Bioinformatics;Biological Assay;Biology;Blood flow;Brain;Brain Stem;Cardiac;cardioprotection;Cardiovascular Diseases;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Cell membrane;Cells;Chronic;clinical practice;Communication;Congestive Heart Failure;Contracts;Cytosol;Defense Mechanisms;Disease;Distant;Echocardiography;Electric Stimulation;Electrocardiogram;Electrophysiology (science);Erythroid;Exercise;exercise training;extracellular vesicles;Femur;Free Radicals;Functional disorder;Goals;Health;Heart;heart function;hemodynamics;Hindlimb;Homeostasis;Human;improved;indexing;innovation;insight;intercellular communication;Intervention;Investigation;Ischemia;Laboratories;Left;Lipid Bilayers;LoxP-flanked allele;Maintenance;Mass Spectrum Analysis;Measurement;Mediating;Methods;mimetics;Modeling;Molecular;Mus;Muscle;Muscle Contraction;Myocardial;myocardial infarct sizing;Myocardial Ischemia;Myocardial Reperfusion Injury;Myocardium;Nerve;Neurons;novel;Nuclear;Organ;overexpression;Oxidation-Reduction;Oxidative Stress;Parents;particle;Pathway interactions;Performance;Peripheral;pharmacologic;Physical activity;Play;Preparation;prevent;Prognosis;protective factors;Proteins;Proteomics;Rattus;Reactive Oxygen Species;Regulation;release factor;Reperfusion Injury;Reperfusion Therapy;Reporter;Resistance;Rest;Role;sedentary lifestyle;Signal Transduction;Skeletal Muscle;Stress;System;Testing;Tissues;transcription factor;Transgenic Mice;Translating;Travel;Up-Regulation;Ventricular;vesicular release

PROJECT_TITLE: Skeletal Muscle Nrf2: Exercise-Induced Cardiovascular Protection

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Otitis Media;Pediatric;Prevention;Vaccine Related

ORG_NAME: CLARAMETYX BIOSCIENCE, INC.

PHR: Project Narrative  Otitis media (OM) remains the primary infectious bacterial disease in childhood despite the widespread use of pneumococcal conjugate vaccines (PCVs). The use of PCVs has notably altered the dominate bacterial species of OM instead of preventing this highly prevalent pediatric disease. Our CMTX-301 vaccine candidate provides a universal approach to OM due to its potential to prevent OM regardless of causative bacterial pathogen.

PI_NAMEs: MCOSKER, CHARLES C. (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Acute;Address;Adjuvant;Advanced Development;analytical method;Antibiotics;Antibodies;Antigens;assay development;Bacteria;Bacterial Infections;Bacterial Vaccines;Bacteriology;Behavior;Biological Products;Biological Sciences;Cessation of life;Characteristics;Child;Childhood;Chinchilla (genus);Chronic;Clinical;Clinical Trials;co-infection;commercialization;cost effective;Custom;Data;Defense Mechanisms;design;Development;Developmental Delay Disorders;Disease;DNA Binding;Dose;economic impact;Education;Epitopes;Evaluation;Experimental Models;Exposure to;FDA approved;Formulation;global health;Health;hearing impairment;Immune;Immune response;Immune system;Immunization;In Vitro;Infection;Integration Host Factors;Investigational New Drug Application;Laboratories;Language;Language Delays;Lead;lead candidate;Left;manufacture;Mediating;Medical;meetings;member;Microbial Biofilms;Microbiology;model design;Modeling;Moraxella catarrhalis;Nontypable Haemophilus influenza;Office Visits;Operative Surgical Procedures;Otitis Media;Parents;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;permanent hearing loss;Phase;Pneumococcal conjugate vaccine;Positioning Attribute;pre-Investigational New Drug meeting;preclinical evaluation;preclinical safety;prevent;Prevention;Preventive measure;programs;protective efficacy;Protein Family;Proteins;Qualifying;Rattus;Recurrence;Regimen;research and development;research clinical testing;Research Design;Research Personnel;Resolution;response;Safety;Schedule;Serotyping;Streptococcus pneumoniae;Structure;superinfection;Surgical Management;Testing;Toxic effect;Treatment Effectiveness;Vaccination;vaccine candidate;vaccine development;vaccine efficacy;Vaccines;Viral;Wages;Work

PROJECT_TITLE: Development of a Multi-species Vaccine for Prevention of Bacterial Otitis Media


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Severe maternal mortality and morbidity and postpartum depression are growing public health issues, which are of particular concern to minority groups, including African-Americans and Spanish-speaking Latinas. Our proposal aims to improve a patient’s ability to detect warning signs of severe maternal mortality and morbidity and postpartum depression and seek clinical care. The proposed research addresses NIMHD’s research goal of developing and testing interventions to reduce health disparities.

PI_NAMEs: BENDA, NATALIE CHRISTINE (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Acute;Address;Affect;African American;African American population;Age;Area;Award;Cardiology;Cardiomyopathies;Cardiovascular Diseases;care seeking;career;Cessation of life;Clinical;clinical care;Clinical Trials;Communication;Competence;Decision Making;Decision Support Systems;demographics;design;Discipline of Nursing;Discipline of obstetrics;Disease;Disparity;disparity reduction;Education;Effectiveness;Emergency Medicine;Enrollment;ethnic disparity;Ethnic Origin;Evaluation;Event;experience;Feedback;Goals;Guidelines;Gynecology;Health;health application;health disparity;health equity;health information technology;Health Services;Hemorrhage;heuristics;Hospitals;improved;Infection;Informatics;information seeking behavior;Information Technology;Intervention;Interview;K-Series Research Career Programs;Knowledge;Language;Latina;Latina Population;Limited English Proficiency;Maternal Health;maternal morbidity;Maternal Mortality;Measures;Medical;medical schools;Mental Depression;Mentors;mHealth;Minority Groups;minority health;Monitor;Mothers;multidisciplinary;National Institute on Minority Health and Health Disparities;Nature;Obstetrical Nursing;Oncology;Outcome;Paper;Participant;patient oriented;Patient Outcomes Assessments;Patients;Phase;pilot trial;Population Heterogeneity;Postpartum Depression;postpartum outcome;Postpartum Period;Postpartum Women;pre-doctoral;primary outcome;programs;prototype;Psychiatry;Psychology;Public Health;Pulmonary Embolism;Questionnaires;Race;racial disparity;recruit;Reduce health disparities;Reporting;Research;Research Personnel;Research Support;Resources;Risk;Sampling;secondary outcome;Self Efficacy;Self-Injurious Behavior;Sepsis;severe maternal morbidity;Signs and Symptoms;Spanish;Spanish/English;statistics;Structure;Suicide;support tools;Surveys;Symptoms;System;Technology;technology intervention;Testing;therapy design;Training;Training Support;Underserved Population;United States;usability;user centered design;Woman;Women's Health;Work

PROJECT_TITLE: "Maternal Outcome Monitoring and Support (MOMS) - A mHealth symptom self-monitoring and decision support system to reduce racial and ethnic disparities in postpartum outcomes


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative We are proposing to develop a novel ensemble model framework to integrate information across multiple existing air pollution prediction models across the United States and, for the first time, to comprehensively quantify the uncertainty associated with air pollution exposure assessment, in single- and multi-pollutant settings. Subsequently, we propose to propagate the estimated uncertainty in the health effects estimation, to fully characterize the impact of air pollution on adverse health and the shape of the exposure-response curves. The proposed novel paradigm greatly improves communication of exposure uncertainty in the health effect estimates both to policy makers and the public and can easily be extended for use at different locations and at a global scale, as well as for other environmental exposures.

PI_NAMEs: DOMINICI, FRANCESCA ;KIOUMOURTZOGLOU, MARIANTHI-ANNA  (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Accounting;Address;Air Pollution;ambient air pollution;American;Area;Atmosphere;Cessation of life;cohort;Communication;Communication Tools;Data;Data Scientist;Data Set;data sharing;Diameter;disability-adjusted life years;disabled;Elderly;Engineering;Environmental Exposure;Epidemiologist;Exposure to;fine particles;Future;global environment;Goals;Health;Health Insurance;Heterogeneity;Hospitalization;improved;innovation;Joints;Location;Low income;Medicare;Medicare/Medicaid;meter;Methodology;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;New York;Nitrogen Dioxide;novel;open data;open source;Outcome;Ozone;Participant;particle;Pattern;Peer Review;Performance;Policies;Policy Maker;pollutant;Population;predictive modeling;Provider;Regulation;Reporting;Research;Research Priority;Resolution;Resource Sharing;response;Risk Factors;Rural;Seasons;Shapes;Site;Software Tools;spatiotemporal;Statistical Methods;System;Time;tool;Uncertainty;United States National Institutes of Health;Visualization software;Work

PROJECT_TITLE: Integrating Air Pollution Prediction Models: Uncertainty Quantification and Propagation in Health Studies

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: This study examines; 1) coronary artery and heart valve calcification in individuals resilient to pathologic aging, 2) determines if these individuals have an improved ability to remove cholesterol from heart tissues as a potential protective mechanism against cardiac calcification, and 3) explores candidate protective genes against cardiac calcification for the overall aim of identifying new pathways which could be targeted for the prevention or treatment of coronary artery and heart valve disease. The research addresses the National Heart Lung and Blood Institute’s strategic research priorities on the pathobiology of calcification of coronary arteries and heart valves, and resiliency to disease. This research also addresses the broader NHLBI mission to prevent heart disease in older adults, so that Americans not only achieve longevity, but extended healthspan.

PI_NAMEs: BORTNICK, ANNA E (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Address;Adult;Affect;Agatston Score;Age;Aging;aging related disease;American;aortic valve;Apolipoproteins;Ashkenazim;Biological;Biological Markers;calcification;Candidate Disease Gene;Cardiac;Cardiac health;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cell membrane;Centenarian;Cessation of life;Cholesterol;Cholesterol Esters;cohort;Cohort Studies;Congestive Heart Failure;Coronary;Coronary artery;coronary artery calcification;coronary plaque;coronary sinus valve structure;Cross-Sectional Studies;Data;density;Deposition;design;Disease;disorder prevention;Drug Design;epidemiology study;experience;follow-up;follower of religion Jewish;Founder Generation;frailty;Functional disorder;Future;Genes;Genetic;genetic resistance;genetic variant;Genomics;Genotype;Goals;healthspan;Heart;heart disease prevention;Heart Valve Diseases;Heart Valves;Heritability;High Density Lipoproteins;Human;human old age (65+);improved;Incidence;Individual;Inherited;Knowledge;Life;Link;Lipids;Lipoproteins;Longevity;Longitudinal cohort study;Measurement;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Mission;Molecular Epidemiology;Morbidity - disease rate;mortality;Movement;multidisciplinary;Myocardial Infarction;National Heart, Lung, and Blood Institute;novel;novel strategies;offspring;older adult;Operative Surgical Procedures;Parents;Pathologic;pathological aging;Pathway interactions;patient oriented;peer;Persons;pharmacologic;Phenotype;Phospholipids;Population;Population Study;Prevalence;Prevention;Prevention approach;Process;Prospective, cohort study;protective pathway;Proteins;Research;Research Personnel;Research Priority;Research Project Grants;resilience;resilience research;Resistance;reverse cholesterol transport;secondary analysis;Serum;Severities;sex;small molecule;Stroke;Testing;therapeutic target;Tissues;Training;translational goal;Translational Research;variant detection;Work;X-Ray Computed Tomography

PROJECT_TITLE: Cardiac Calcification and Cholesterol Efflux in Older Adults

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Microbiome

ORG_CITY: MADISON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Animal-coloning bacteria transition from an environmental lifestyle to the host-associated state, in which individual bacterial cells coordinate functions to act as a group. Using a model system that allows for interrogation of bacteria within the animal host, this project addresses how the host and microbes exchange and interpret molecular signals, leading to group versus solitary behaviors of the colonizing microbes. This project has ramifications for therapeutic interventions to establish beneficial microbes (e.g. probiotics) and to understand and interfere with colonization by pathogenic microbes.

PI_NAMEs: MANDEL, MARK J (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Address;Animals;antimicrobial;Bacteria;Bacterial Genes;Behavior;beneficial microorganism;Biological Models;Cells;Chemicals;Communication;Environment;Exclusion;genetic analysis;genetic approach;genetic manipulation;Goals;host colonization;host-microbe interactions;Hour;Image;Immune;Individual;Infection;Investigation;Laboratories;Laboratory Study;Life Style;Ligands;Light;Microbe;Microbial Biofilms;microbiome;Modeling;Molecular;novel;Organ;pathogenic microbe;Play;Probiotics;Process;protein function;Proteins;Reproducibility;RNA-Binding Proteins;Route;Seawater;Signal Pathway;Signal Transduction;Site;small molecule;Specificity;Squid;success;symbiont;System;Therapeutic Intervention;transmission process;V. fischeri-squid system;Vibrio fischeri;Work

PROJECT_TITLE: Genetic analysis of beneficial bacterial colonization

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Gene Therapy;Genetics;Hematology;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Sepsis

ORG_CITY: GREER

ORG_NAME: NUBAD, LLC

ORG_STATE: SC

PHR: The work proposed here, a multidisciplinary effort encompassing organic synthesis, oligonucleotide delivery, RNA targeted screening and antibacterial studies, describes the development of sequence-specific cell permeable binders of rRNA as antibacterial therapeutics. The success of the proposed work would be a significant addition to currently available ribosome-specific approaches in broad spectrum antibacterial antibiotic development, in particular for targeting gram negative pathogens such as carbapenem-resistant Enterobacteriaceae (CRE). We propose using a small rRNA target sequences to design conjugates that can be employed to inhibit bacterial growth, opening possibilities for developing sequence-specific RNA targeted therapeutics.

PI_NAMEs: ARYA, DEV PRIYA (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Abdominal Infection;Address;Amides;Amino Sugars;Aminoglycosides;Anti-Bacterial Agents;anti-microbial drug;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;antimicrobial;Antimicrobial Resistance;antimicrobial resistant infection;Bacillus;Bacteria;Bacterial Infections;Bacterial Pneumonia;Bacterial Proteins;bacterial resistance;base;Binding;Biodistribution;Biological Assay;Biological Availability;Biology;Books;candidate identification;carbapenem-resistant Enterobacteriaceae;Cavia;Cell Wall;Cells;Cessation of life;Chemicals;Clinical;Colistin;combat;Communicable Diseases;Congresses;Coronavirus;cost;Coupled;COVID-19;COVID-19 mortality;Creativeness;Data;design;Development;Disease;Dose;Drug Design;drug development;Drug Interactions;Drug resistance;Drug Targeting;economic impact;efficacy study;Elements;Ensure;Enterobacteriaceae;Epidemic;Escherichia coli;Eukaryota;extensive drug resistance;Face;Family;fighting;Follow-Up Studies;Gram-Negative Bacteria;Growth;Health Care Costs;improved;In Vitro;in vivo;Infection;Influenza;Influenza A Virus, H1N1 Subtype;inhibitor;innovation;Institute of Medicine (U.S.);Intervention;Intra-abdominal;Klebsiella pneumoniae;Knowledge;L Forms;Lead;Left;Length of Stay;Libraries;Link;Locales;Lung Diseases;Lung infections;Malaria;Membrane;microbial;Microbial Biofilms;Modeling;mortality;Multi-Drug Resistance;multidisciplinary;Mus;Nosocomial Infections;novel;novel antibiotic class;novel therapeutic intervention;novel therapeutics;Nucleic Acid Binding;nucleic acid delivery;Nucleic Acids;oligonucleotide delivery;Oligonucleotides;Organic Synthesis;ototoxicity;pandemic influenza;pathogen;pathogenic bacteria;Pathogenicity;Patients;Peptide Nucleic Acids;Peptides;Permeability;Pharmaceutical Preparations;Phase;Pneumonia;pre-clinical;pre-Investigational New Drug meeting;preclinical study;Predisposition;prevent;priority pathogen;Prokaryotic Cells;Proliferating;Protein Biosynthesis;Protein Synthesis Inhibitors;Rapid screening;Rattus;Reporting;Research;Resistance;Resistance profile;Ribosomal RNA;Ribosomes;Risk;RNA;RNA Binding;RNA Sequences;RNA-targeting therapy;screening;Sepsis;Severe Acute Respiratory Syndrome;Severities;Societies;Solid;Specificity;Staphylococcal Infections;Structure;success;Superbug;Surgeon;synergism;Tail;targeted agent;Technology;Therapeutic;Thigh structure;tigecycline;Time;Tobramycin;Toxic effect;Translation Initiation;Tuberculosis;United States;United States National Academy of Sciences;uptake;Urinary tract infection;Viral;Work;World Health;World Health Organization

PROJECT_TITLE: Development of peptide nucleic acid antibiotics


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Prevention

ORG_CITY: Columbus

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Proliferative vitreoretinopathy (PVR) is a fibrotic complication that causes retinal folds and/or traction retinal detachment resulting in loss of visual acuity, and in severe cases, blindness. We propose to study signaling mechanisms involving both cells and the fibrotic extracellular matrix that creates a positive feedback loop that results in PVR. The ultimate aim is to identify key molecules that can become therapeutic targets for the prevention of PVR.

PI_NAMEs: TAMIYA, SHIGEO  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Actins;Affect;Animal Model;Atomic Force Microscopy;Back;Blindness;Calcium;Cell Nucleus;cell type;Cells;Characteristics;Cicatrix;Collagen;Complication;Contracts;crosslink;Data;Deposition;Development;Disease;Enzymes;Epiretinal Membrane;Extracellular Matrix;Eye Injuries;Family;Feedback;Feeds;fibrillogenesis;Fibronectins;Fibrosis;Gene Expression;Glutaminase;Goals;In Vitro;in vivo;Intervention;knock-down;Literature;Liver Fibrosis;Measures;Molecular;molecular targeted therapies;Muller's cell;myocardin;Myofibroblast;Myosin Light Chain Kinase;Nuclear;Nuclear Translocation;Operative Surgical Procedures;Patients;Phosphotransferases;polymerization;Polymers;porcine model;prevent;Prevention;Production;profibrotic cytokine;Profibrotic signal;Proliferative Vitreoretinopathy;Protein-Lysine 6-Oxidase;Proteins;PTK2B gene;Publishing;Pulmonary Fibrosis;receptor;repaired;Retina;Retinal Detachment;rho;Role;Sampling;Series;Serum Response Factor;Signal Induction;Signal Transduction;small hairpin RNA;Small Interfering RNA;src-Family Kinases;Structure of retinal pigment epithelium;Surface;Testing;therapeutic target;Time;Tissues;Traction;transcription factor;transdifferentiation;Transforming Growth Factor beta;Vanilloid;Visual Acuity;wound

PROJECT_TITLE: Role of MRTF signaling in proliferative vitreoretinopathy

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: MILWAUKEE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Project Narrative The rat has been a primary animal model used to study complex human biology, disease, and biological processes because of the wealth of available biological information, genetic, genomic, and additional molecular systems data. Integrating these datasets with those for human and other mammalian models of human disease, are critical to advancing our knowledge of human health and disease. The primary mission of RGD is to provide novel ways to integrate the vast amount of genomic and biological data for the rat, with similar data in human and other mammalian disease models, to provide a unique comparative discovery platform for researchers to identify and evaluate precision rat models, test novel hypotheses, and make vital discoveries related to human health and disease.

PI_NAMEs: KWITEK, ANNE E. (contact)

PROGRAM_OFFICER_NAME: LUO, JAMES

PROJECT_TERMS: Animal Model;Animals;ATAC-seq;Biological;Biological Process;Catalogs;Cells;Collaborations;Communities;comparative;Comparative Study;Complement;Complex;Cross Presentation;Data;data integration;data resource;Data Set;Disease;disease model;Ecosystem;Environment;epigenome;epigenomics;flexibility;Funding;Funding Agency;gene function;Genes;Genetic;Genetic Diseases;genetic information;Genetic Markers;Genetic Predisposition to Disease;genetic variant;Genetic Variation;Genome;genome resource;genome sequencing;genome wide association study;genomic data;genomic locus;Genomics;Goals;Health;Heart Diseases;Hematological Disease;Human;Human Biology;human data;human disease;human model;Hybrids;improved;in silico;Infrastructure;insight;International;Investments;Knowledge;Length;Lung Diseases;Manuals;Maps;member;Methods;Mining;Mission;model organism;model organisms databases;Modeling;Molecular;Multiomic Data;multiple datasets;multiple omics;Mus;mutant;novel;Nuclear RNA;Nucleic Acid Regulatory Sequences;Ontology;Organism;Orthologous Gene;Phenotype;phenotypic data;Physiological;Population;pre-clinical;Pre-Clinical Model;Process;Quantitative Trait Loci;Rat Genome Database;Rat Strains;Rattus;reference genome;Regulation;Research;Research Personnel;research study;Resources;RNA;Sleep Disorders;species difference;Synteny;System;Testing;Time;tool;tool development;Transcript;transcriptome;Translations;United States National Institutes of Health;Variant;Visualization;whole genome;Widespread Disease

PROJECT_TITLE: Rat Genome Database

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;HIV/AIDS;Infectious Diseases;Microbiome

ORG_NAME: WISTAR INSTITUTE

PHR: PROJECT NARRATIVE Altered cell-surface carbohydrates (glycans) play an important role in different infectious and inflammatory diseases of the gut, which is also a key site of HIV pathogenesis and persistence. This study will investigate the role of altered gut carbohydrates in modulating the gut microbiome and mediating HIV-associated gut inflammation. The idea is that, if these glycan structures are altered, then by understanding exactly how they are altered, we will lay the groundwork for developing novel therapeutic strategies to reduce HIV-associated chronic inflammation, and lifelong co-morbidities.

PI_NAMEs: ABDEL MOHSEN, MOHAMED  (contact);KESHAVARZIAN, ALI ;LANDAY, ALAN L

PROGRAM_OFFICER_NAME: NGUYEN, KHOA DINH DANG

PROJECT_TERMS: antiretroviral therapy;Biopsy;Carbohydrates;Catabolism;Cell surface;Chronic;Communicable Diseases;comorbidity;Data;design;Development;Diet;Disease;DNA;dysbiosis;Ethnic Origin;Excision;Feedback;Female;Fucose;Gender;Gene Expression;General Population;Glycoproteins;glycosylation;gut inflammation;gut microbiome;gut microbiota;HIV;HIV anti-retroviral;HIV Infections;HIV Seronegativity;Homeostasis;Human;ileum;immune activation;Impairment;in vivo;Individual;Infection;Inflammation;Inflammatory;inflammatory marker;inhibitor;intestinal barrier;intestinal epithelium;Intestines;Kinetics;Link;Macaca;Macaca nemestrina;male;Mediating;Metagenomics;microbial;microbial composition;microbiome;microbiome alteration;microbiome composition;microbiota;Modeling;Mucous Membrane;Mus;Neuraminidase;novel strategies;novel therapeutic intervention;Pathogenesis;Pattern;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Plasma;Play;Polysaccharides;preference;prevent;Primates;Publishing;Reporting;RNA;Role;Sampling;Shapes;Sialic Acids;sialylation;Sigmoid colon;Site;SIV;Structure;Symbiosis;systemic inflammatory response;Testing;Time;Viral;virulence gene;Work

PROJECT_TITLE: Glycomic Modulation of Gut Microbiome During HIV Infection


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Nanotechnology;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Here we propose an improved influenza vaccine that can act more broadly to prevent infection from viruses that have undergone natural genetic changes that prevent current flu vaccines from being efficacious. Our goal is to formulate computer generated influenza antigens (COBRA antigens) into degradable biopolymeric (Ac-DEX) nanoparticles to improve the vaccine’s efficacy by co-delivering immune activating adjuvants.

PI_NAMEs: AINSLIE, KRISTY M (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: Acetals;Acids;Address;Adjuvant;Affect;Agonist;Algorithms;aluminum sulfate;Animal Model;Animals;Anthrax disease;Anti-viral Agents;Antibody Response;Antigen Presentation;Antigens;Avian Influenza;B-Cell Activation;Biopolymers;Birds;CD4 Positive T Lymphocytes;Cells;Cessation of life;computer generated;Consensus;controlled release;cost effective;Cytosol;Data;Dependence;design;Dextrans;Dose;Drug Delivery Systems;Emergency Situation;Emulsions;Encapsulated;Endotoxins;Evaluation;FDA approved;Ferrets;flu;Formulation;Genetic Drift;Glycolates;Goals;head-to-head comparison;Hemagglutinin;Hour;Human;Immune;Immune response;immunological synapse;immunoregulation;improved;Individual;Infection;Infection prevention;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;influenza infection;influenza virus vaccine;influenzavirus;innovation;Intramuscular;Methodology;Modeling;mouse model;Mus;Mutation;nano;nanoparticle;Neuraminidase;new pandemic;Nose;novel;pandemic disease;pandemic influenza;particle;Particulate;Pathogenesis;Pathogenicity;Pathology;Periodicity;Phagocytes;Phagosomes;Plague;Polyesters;Polymers;Population;prevent;process optimization;protective efficacy;Protein Denaturation;Protein Subunits;receptor;response;Route;Schedule;Seasons;Shapes;Stimulator of Interferon Genes;Subunit Vaccines;Surface;System;Testing;Toxic effect;Vaccinated;Vaccination;vaccine delivery;vaccine efficacy;vaccine evaluation;vaccine formulation;Vaccines;Viral Load result;Virus Diseases

PROJECT_TITLE: Optimizing a Universal Influenza Subunit Nano/Microparticulate Vaccine

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Digestive Diseases;Food Allergies;Infectious Diseases;Microbiome;Nutrition

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative IBD, food allergies and Celiac disease are caused by dysregulated mucosal immune responses to microbial or dietary antigens. The studies proposed here utilize single-cell and in vivo murine, dietary, bacterial and viral approaches to define immune regulatory and inflammatory T cells in specific niches of the intestine, providing a new perspective for the understanding of intestinal health and inflammation.

PI_NAMEs: MUCIDA, DANIEL S (contact)

PROGRAM_OFFICER_NAME: PERRIN, PETER J

PROJECT_TERMS: absorption;Address;Affect;Allergens;Allergic;Anti-Inflammatory Agents;antigen-specific T cells;Antigens;Bacteria;CD4 Positive T Lymphocytes;Celiac Disease;Cell Communication;Cell Differentiation process;cell motility;Cell Separation;Cells;Characteristics;Charge;Clone Cells;commensal bacteria;commensal microbes;Cues;Data;Development;Diet;dietary;dietary manipulation;Digestion;Enteral;enteric infection;enteric pathogen;Epithelial Cells;Equilibrium;Flow Cytometry;Food;food antigen;Food Hypersensitivity;functional outcomes;Funding;Genetic;Germ-Free;Gnotobiotic;gut homeostasis;gut inflammation;Health;Hypersensitivity;ileum;Immune;Immune response;Immune system;Immunity;Immunization;Immunology;in vitro Assay;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;intestinal epithelium;intestinal homeostasis;Intestinal Mucosa;Intestines;intraepithelial;Label;Lamina Propria;Lymphocyte;Maps;mesenteric lymph node;microbial;microbiota;microorganism antigen;migration;Modeling;Molecular;Mucosal Immune Responses;Mucous Membrane;Mus;novel;novel strategies;Oligonucleotides;Oral Administration;oral tolerance;pathogen;Pathologic;Peripheral;Phenotype;Physiological;Predisposition;Property;Proteins;Publishing;recruit;response;Role;Shapes;Signal Transduction;single cell sequencing;Specificity;Stimulus;T cell response;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Tissues;tool;transcriptomics;Translating;Viral;Virus;Virus Diseases

PROJECT_TITLE: Intestinal CD4 T cell responses to dietary and microbial antigens


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Injury - Accidents and Adverse Effects

ORG_CITY: BOSTON

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

ORG_STATE: MA

PHR: PROJECT NARRATIVE In older adults, the complex task of walking is controlled in large part by multiple brain networks that enable one to pay attention to their surroundings, process sensory information, and produce appropriate movements of the body. This career development proposal aims to determine whether a form of non-invasive brain stimulation called transcranial direct current stimulation (tDCS) can change brain network function and thus improve walking in older adults with unsteady gait. This project is expected to increase our understanding of the brain-level control of walking in older adults, and produce critical information needed to design a larger clinical trial of tDCS to enhance gait and mobility in older adults.

PI_NAMEs: CARRETIE, SABRINA ;LO, ON-YEE AMY (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acute;Aging;Attention;Brain;Brain imaging;career;career development;Clinical Research;Clinical Trials;Cognition;cognitive neuroscience;cognitive task;cohort;Complex;Data;design;Disease;Dorsal;effective intervention;Electrodes;Eligibility Determination;evidence base;Exhibits;Exposure to;fall risk;falls;follow-up;Frequencies;Functional Magnetic Resonance Imaging;Gait;gait rehabilitation;Geriatrics;Goals;Impaired cognition;improved;Individual;Injury;innovation;interest;Intervention;Lead;Link;Magnetic Resonance Imaging;Measures;Mind;Motion;Movement;multimodality;neural;neuroimaging;neuromechanism;neuroregulation;noninvasive brain stimulation;novel;older adult;Outcome;Participant;patient oriented;Pattern;Performance;post intervention;primary outcome;Randomized;recruit;Rehabilitation therapy;Research;Rest;Scalp structure;Scientist;secondary analysis;secondary outcome;Sensory Process;smartphone application;sustained attention;Techniques;Testing;Time;Training;transcranial direct current stimulation;treatment arm;Unsteady Gait;Visit;Walking;Work

PROJECT_TITLE: Modulating brain networks to reduce gait variability in older adults at risk of falling

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: BALTIMORE

ORG_DEPT: CHEMISTRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The proposed investigations address fundamental aspects of the chemistry of copper and heme-copper coordination complexes with molecular oxygen and nitrogen oxides such as nitric oxide. The interactions of these biologically important gaseous small molecules, especially at metalloenzyme active-sites, are critical in normal functioning and health. Potential long-term applications of this basic research include development of enzyme inhibitors as drugs and relevant disease therapeutic strategies.

PI_NAMEs: KARLIN, KENNETH D. (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Active Sites;Address;Basic Science;Binding;Biochemical;Biological;Carbon Dioxide;Chemistry;cofactor;Complex;Copper;Copper Chelation;Coupled;Coupling;cytochrome c oxidase;design;Development;Disease;Dopamine-beta-monooxygenase;electron donor;Enzyme Inhibitor Drugs;Enzymes;Family;Health;Heme;Hydrogen Bonding;Hydrogen Peroxide;Hydroxylation;hyponitrite;Investigation;Ions;Ligands;Ligation;Lytic;Mediating;metalloenzyme;Metals;Methane hydroxylase;Mixed Function Oxygenases;Modeling;Mole the mammal;Molecular;Nature;Nitric Oxide;Nitrogen Oxides;Nuclear;Oxidases;Oxidoreductase;Oxygen;Particulate;peptidylglycine alpha-amidating monooxygenase;Peroxonitrite;Pharmaceutical Preparations;Phenols;physical property;Polysaccharides;Process;programs;Proteins;Protons;Research;Role;small molecule;Spectrum Analysis;Structure;Therapeutic;Water

PROJECT_TITLE: Reactivity-Activation of O(2) or NO in Copper and Heme-Cu Coordination Complexes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Data Science;Machine Learning and Artificial Intelligence;Precision Medicine

ORG_CITY: ATHENS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative Many human diseases including cancer, diabetes, and inflammatory disorders are causally associated with abnormal protein kinase and glycosyltransferase functions. By characterizing the regulatory functions of these proteins in disease and normal states and by developing new tools to predict disease phenotypes from genotypes, the proposed studies will accelerate the targeting of these proteins for drug discovery and personalized medicine.

PI_NAMEs: KANNAN, NATARAJAN  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Address;age-related disease;Allosteric Regulation;Allosteric Site;Biochemical;biological adaptation to stress;Biological Assay;Biology;Complex;Computer Models;Cysteine;data integration;Data Set;Diabetes Mellitus;Disease;disease phenotype;drug discovery;Gene Family;Genome;Genotype;glycosyltransferase;Goals;human disease;in vivo;Inflammatory;knowledge graph;Link;Machine Learning;Malignant Neoplasms;Maps;Mass Spectrum Analysis;member;Mining;Modeling;molecular dynamics;Mutation;Oncogenic;Oxidation-Reduction;Oxidative Stress;Patients;personalized medicine;phenome;Phosphotransferases;predictive modeling;protein function;Protein Kinase;Proteins;Receptor Protein-Tyrosine Kinases;Regulation;Resources;Signal Transduction;Site;small molecule;Structure;sulfotransferase;System;Technology;tool;Work

PROJECT_TITLE: Unlocking sequence-structure-function-disease relationships in large protein super-families


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Microbiome;Nutrition;Obesity;Patient Safety;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Metabolic and bariatric surgery provides a unique opportunity to study the role of gut microbiota in human cardiometabolic health. Very few longitudinal studies among metabolic and bariatric surgery patients, however, have examined pre- to post-surgery changes in gut microbiome and microbial metabolites and the associations of microbiome and metabolites with cardiometabolic improvements after surgery. The proposed study seeks to bridge this research gap by identifying novel microbial features that may improve metabolic surgery outcome prediction (eg; the estimated 10-year risk of atherosclerotic cardiovascular disease) and may guide potential future microbiota-targeted interventions to help patients achieve better cardiometabolic health.

PI_NAMEs: YU, DANXIA  (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Affect;African American population;Assessment tool;Atherosclerosis;atherosclerosis risk;bariatric surgery;beta-Hydroxybutyrate;Bile Acids;Biological Assay;blood lipid;Blood Pressure;Blood specimen;Body mass index;Cardiometabolic Disease;cardiometabolism;cardiovascular disorder risk;care providers;caucasian American;Clinical;clinical practice;clinical predictors;clinically significant;cohort;Data;design;detection assay;Development;Diet;Diet Modification;Dyslipidemias;Effectiveness;Enrollment;Evaluation;experience;Feces;Fiber;Foundations;Future;General Population;Genes;glycemic control;Goals;Guidelines;gut microbiome;gut microbiota;Health;host microbiota;Human;Hypertension;improved;Individual;Indoles;innovation;insight;Intake;Intervention;Investigation;Knowledge;LDL Cholesterol Lipoproteins;Life Style;Literature;Longitudinal cohort;Longitudinal Studies;Metabolic;Metabolic Diseases;metabolomics;Metagenomics;Metformin;Microbe;microbial;microbiome;microbiota;microbiota metabolites;Modeling;multi-ethnic;multiple omics;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Operative Surgical Procedures;Outcome;outcome prediction;Pathway interactions;Patients;Pharmaceutical Preparations;Pilot Projects;Population;Positioning Attribute;prebiotics;prevent;Prevotella;primary outcome;Probiotics;prospective;Prospective cohort;Protocols documentation;Recommendation;recruit;Research;Research Personnel;Risk;Risk Reduction;Role;Sample Size;Sampling Studies;secondary outcome;stool sample;surgery outcome;Surveys;Testing;Time Study;Translating;Ursodeoxycholic Acid;Visit;Volatile Fatty Acids;Work;Yogurt

PROJECT_TITLE: The Gut Microbiota in Metabolic Surgery: A Multi-Ethnic, Multi-Omic, Longitudinal Study

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Neurosciences;Pediatric

PHR: Project Narrative The vascular and neural networks of the kidney help maintain physiological homeostasis. Engineering new organs and regenerative therapies to treat disease will require the proper establishment of these networks, however, little to nothing is known about how neurovascular networks are formed in the kidney. Our proposed research will provide critical insights into how these networks are established, their influence on kidney development, and the implications of proper neurovascular development for physiological function.

PI_NAMEs: O'BRIEN, LORI L (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Ablation;Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;Affect;Age;Attention;blood filtration;Blood flow;Blood Pressure;Blood Vessels;candidate identification;Cell Physiology;Cells;Chemical Sympathectomy;Chemicals;Chronic Kidney Failure;Congenital Abnormality;congenital anomaly;Cues;Denervation;Development;Dialysis procedure;Differentiation and Growth;Disease;Disease Progression;Embryo;Endothelial Cells;Engineering;Familial Dysautonomia;fetal;Genetic;Goals;Health;Heart;Homeostasis;Hormone secretion;Human;human induced pluripotent stem cells;Imaging Techniques;in vivo;Injury to Kidney;insight;Investigation;Kidney;Kidney Diseases;Kidney Transplantation;Knock-out;Knowledge;Mediating;Mediator;Methodology;Modeling;Modernization;mouse model;Mus;mutant;Natural regeneration;Neonatal;nephrogenesis;Nerve;nerve supply;netrin-3;neural network;Neurodevelopmental Disorder;neurovascular;new therapeutic target;Newborn Infant;novel;novel therapeutic intervention;NTN1 gene;Organ;Organ Donor;organ growth;Organoids;Pancreas;Paracrine Communication;Pathway interactions;Patients;Pattern;Phenotype;Physiological;Physiology;Play;prevent;Process;Rationalization;regenerative therapy;Regulation;release factor;Renal function;repaired;Research;Role;Salivary Glands;Seminal;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;Three-Dimensional Imaging;Tissues;Transplantation;virtual;Work

PROJECT_TITLE: Trophic interactions directing proper kidney development

STUDY_SECTION: KMBD

STUDY_SECTION_NAME: Kidney Molecular Biology and Genitourinary Organ Development[KMBD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases

ORG_CITY: BOCA RATON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative There is an unmet need to develop HIV self-tests for rapid diagnosis and disease management. Our goal is to develop a disposable, sensitive, true sample-in-answer-out, and refrigeration-free self-testing device to rapidly detect HIV from whole blood samples. 1

PI_NAMEs: ASGHAR, WASEEM  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Acute;acute infection;Address;Antibody Response;antiretroviral therapy;Automation;Biological Assay;Biological Markers;Blood specimen;Cessation of life;commercialization;Communicable Diseases;Contracts;Country;design;Detection;Development;Devices;Diagnostic;Disease Management;Dryness;fabrication;Fingers;Flavivirus;glucose monitor;Goals;Heating;Hepatitis;HIV;HIV Infections;HIV Seropositivity;HIV-1;Human immunodeficiency virus test;Image;improved;Individual;Infection;Intervention;isothermal amplification;Magnetism;Malaria;Mediating;Methods;microchip;microelectronics;Microfluidic Microchips;Microfluidics;Monitor;novel;Patients;Persons;Phase;Prevalence;Protocols documentation;rapid detection;rapid diagnosis;Reaction;Reagent;Refrigeration;Reverse Transcriptase Polymerase Chain Reaction;RNA;Sampling;self testing;Sensitivity and Specificity;Specificity;Speed;statistics;System;Technology;Testing;Time;Treatment Failure;Treatment outcome;Tuberculosis;Validation;Viral;Viral Genome;viral rebound;Virus;virus culture;Whole Blood

PROJECT_TITLE: Development of an automated HIV self-testing assay


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Immunization;Infectious Diseases;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Vaccine Related

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Pathogens from Enterobacteriaceae are responsible for high rates of diarrheal disease, kidney illness, meningitis, urinary tract infections and bowel inflammation worldwide, and a major cause of childhood mortality in developing countries. This proposal aims to characterize a novel class of highly conserved family of small regulatory proteins (termed ANR), associated with the modulation of virulence of epidemiologically relevant pathogens. The findings will greatly advance our understanding on bacterial pathogenesis and will have significant implications in treatment and prevention of infections in humans.

PI_NAMEs: SANTIAGO, ARACELI ELVIRA (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acute;Affect;Animal Disease Models;Attenuated;Bacteria;Bacterial Genome;Binding;Biochemical;biological adaptation to stress;Biological Assay;Cells;Centers for Disease Control and Prevention (U.S.);Childhood;ChIP-seq;Citrobacter;Citrobacter rodentium;Clinical;clinically relevant;Coupled;Data;Developing Countries;diarrheal disease;Disease;DNA Binding;DNA-Protein Interaction;enteric infection;enteric pathogen;enteroaggregative Escherichia coli;Enterobacteriaceae;enteropathogenic Escherichia coli;Epidemiology;Exhibits;Family;fitness;Fluorescence Microscopy;Gastroenteritis;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;genetic regulatory protein;Genetic Transcription;genome-wide;Goals;Gram-Negative Bacteria;gut colonization;gut inflammation;Histones;Homologous Gene;Hospitalization;Host Defense;Human;human stem cells;Impairment;In Vitro;in vivo;Infection;Infection prevention;insight;Intestines;Kidney;Knowledge;Lifting;Maps;member;Meningitis;Metabolism;Microscopy;Modeling;Molecular;Morbidity - disease rate;mortality;murine colitis;mutant;novel;novel therapeutics;novel vaccines;pathogen;Pathogenesis;pathogenic bacteria;pathogenic Escherichia coli;Phenotype;Play;Protein Family;protein protein interaction;Proteins;prototype;Public Health;Regulation;Regulon;Repression;Role;Salmonella;Shigella;stem cell technology;stem cells;Structure;Surface Plasmon Resonance;System;Therapeutic Intervention;Toxin;trait;transcriptome;Type III Secretion System Pathway;Urinary tract infection;vaccine strategy;Vaccines;Vibrio;Virulence;Virulence Factors;virulence gene;Yersinia

PROJECT_TITLE: Characterization of a novel family of Small Regulatory Proteins modulating virulence in Enterobacteriaceae

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Defects in homeostatic signaling at synapses are associated with a variety of neurological and neuropsychiatric diseases including epilepsy, autism, schizophrenia, Fragile X Syndrome, ALS, and Alzheimer's Disease. However, the mechanisms that ensure stable synaptic strength remain poorly understood. This proposal seeks to reveal fundamental mechanisms that initiate and maintain homeostatic signaling at synapses, insights that are necessary for understanding disease etiology.

PI_NAMEs: DICKMAN, DION KAI (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Acute;Aging;Alzheimer's Disease;Amino Acids;autism spectrum disorder;Biological Models;C-terminal;calmodulin-dependent protein kinase II;Central Nervous System;Chemosensitization;Chronic;Communication;Complex;Data;Defect;density;Development;Disease;DLG4 gene;Drosophila genus;Electrophysiology (science);Endowment;Ensure;Epilepsy;Etiology;excitotoxicity;experience;experimental study;flexibility;Fragile X Syndrome;Functional disorder;Functional Imaging;gene interaction;Genes;Genetic;Genetic Screening;Glutamate Receptor;Glutamates;Goals;Growth;Health;Homologous Gene;Human;Image;imaging approach;Impaired cognition;innovation;insight;Invertebrates;Learning;Mediating;Modeling;Molecular;Molecular Genetics;Motor Neurons;Nature;Nerve Degeneration;Nervous System;Nervous System Disorder;Neuromuscular Junction;neuropsychiatric disorder;neuroregulation;neurotransmission;Neurotransmitter Receptor;neurotransmitter release;novel;Organism;Pathway interactions;Peripheral Nervous System;pharmacologic;postsynaptic;presynaptic;Process;receptor function;recruit;Rodent;Role;scaffold;Schizophrenia;Seizures;Signal Transduction;sleep behavior;Structure;Synapses;synaptic function;Synaptic plasticity;System;Tail;Testing;transmission process;ubiquitin ligase;ubiquitin-protein ligase;ultra high resolution;Work

PROJECT_TITLE: Molecular Mechanisms Governing the Homeostatic Control of Synaptic Strength

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Genetics

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative Protein-nucleic acid complexes work in living cells to faithfully replicate (copy) the DNA genome to form the genetic material of the daughter cells, to transcribe and process specific messenger RNA sequences to permit `expression' of the defined genes, and to direct the synthesis of specific required proteins at various stages of development. These molecular complexes, which drive and direct these central processes of cellular function, largely self-assemble from individual protein and nucleic acid components to form the so-called `macromolecular machines of gene expression'. We are continuing a program of research that uses the methods of physics and chemistry to understand the specific molecular processes that are involved in the function and regulation of these machines, in part because understanding these central processes in molecular detail will help in the development of specific tools to control diseases of anomalous gene expression and development, including various forms of cancer and related genetic diseases.

PI_NAMEs: MARCUS, ANDREW HADLEY (contact);VON HIPPEL, PETER H

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: absorption;analog;ATP Hydrolysis;Automobile Driving;Bacteriophage T4;base;Binding;Binding Proteins;Biochemical;Biological Models;Biological Monitoring;Biophysics;Breathing;Cell Physiology;Cells;Chemistry;Circular Dichroism;Circular Dichroism Spectroscopy;Closure by clamp;Collaborations;Complex;cyanine dye;daughter cell;Dependence;Development;dichroism;Disease;disorder control;DNA;DNA biosynthesis;DNA Primase;DNA replication fork;DNA-Protein Interaction;ds-DNA;Elements;Enzymes;Equilibrium;Escherichia coli;experimental study;Fluorescence;Fluorescence Resonance Energy Transfer;Fluorescence Spectroscopy;Free Energy;Gene Expression;Genes;Genetic Diseases;Genetic Materials;Genetic Transcription;Genome;Goals;Grant;helicase;Holoenzymes;Human;human DNA;In Vitro;in vivo;Individual;innovation;insight;Joints;Kinetics;Label;Laboratories;Life;Macromolecular Complexes;Malignant Neoplasms;Maps;Measurement;Measures;Mediating;Messenger RNA;Methods;millisecond;Minor;Modeling;Molecular;Molecular Conformation;novel;Nucleic Acids;Optics;Oregon;Organism;Pathway interactions;Physics;Polymerase;Positioning Attribute;Process;professor;programs;Property;protein complex;Proteins;Reaction;reconstitution;Regulation;Reporting;Research;Research Project Grants;Research Proposals;Resolution;RNA Sequences;Role;self assembly;Signal Transduction;single molecule;Single-Stranded DNA;Site;Slide;SS DNA BP;Structure;Sugar Phosphates;Surface;System;Time;tool;two-dimensional;Universities;Vertebral column;Work

PROJECT_TITLE: Structure and Relations of Protein and Nucleic Acids

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Digestive Diseases;Immunization;Infectious Diseases;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Necrotizing enterocolitis (NEC) is a terrible disease that affects approximately 7% of premature children and is lethal in 25-30% of cases. Maternal milk has been shown to reduce the incidence of NEC and this study proposes to investigate the role of maternal antibodies secreted into the milk in preventing bacterial invasion of the intestine and disease. Our proposal aims to describe the mechanism via which maternal milk protects the intestine via shaping the neonatal bacterial flora via specific binding to individual bacterial strains.

PI_NAMEs: HAND, TIMOTHY WESLEY (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Affect;Anti-Bacterial Agents;Antibodies;Antibody Repertoire;Antibody-mediated protection;Area;Asthma;B-Lymphocytes;Bacteria;bacterial community;bacterial genome sequencing;Benign;Binding;Cause of Death;Cells;Child;Chronic Disease;Communities;cost;Dangerousness;Data;de novo mutation;Development;Disease;donor milk;Drops;Enterobacteriaceae;Epithelium;Generations;Genetic Transcription;Gnotobiotic;gut microbiota;Health;Heterogeneity;Human Milk;IgA Deficiency;Immune;Immune response;Immune system;Immunoglobulin A;improved;Incidence;Individual;Infant;Infection;Infection prevention;Infiltration;Inflammatory;intestinal epithelium;Intestinal Mucosa;Intestines;Invaded;Knowledge;Link;Mammary gland;Maternal antibody;Measures;Mediating;microbial community;microbiome;microbiota;Milk;Milk Banks;model organism;Mothers;mouse model;Mucosal Immune Responses;Mucous Membrane;Mus;Mutation;Necrotizing Enterocolitis;Neonatal;neonatal mice;neonate;novel;Obesity;pathogen;Predisposition;premature;Premature Infant;Premature Infant Diseases;prevent;Preventive therapy;Production;Property;prospective;protective effect;pup;Rag1 Mouse;Research;response;Risk;Role;Sampling;Secretory Immunoglobulin A;Sepsis;Shapes;Source;stool sample;Structure;T-Lymphocyte;Taxon;Testing;Therapeutic;transcriptome;Variant;Woman

PROJECT_TITLE: Mechanisms of maternal Immunoglobulin A control over the neonatal microbiota and the development of Necrotizing Enterocolitis.

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Comparative Effectiveness Research;Digestive Diseases;Health Services;Liver Disease;Patient Safety;Prevention;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Cirrhosis affects 1.5-9.4 million adult Americans and is associated with high morbidity, hospitalization rates, and mortality with mean life expectancy being 12 years for compensated and 1.8 years for decompensated cirrhosis. Costs are high for patients with cirrhosis, exceeding $16.3 billion in 2015 for hospitalizations alone, but little detailed knowledge about cost and cost-effectiveness related to cirrhosis exists. We will use administrative health payer data with detailed information on diagnoses, procedures, laboratory tests, medications, in- and outpatient care, as well as standardized costs in 396,727 persons diagnosed with cirrhosis between 2011 and 2018 to study the natural history of liver cirrhosis and to develop highly accurate models to predict decompensation of cirrhosis, hospitalization and death in patients with cirrhosis as well as cost analyses, thus identifying opportunities to improve care.

PI_NAMEs: LADNER, DANIELA P (contact);MANSKI, CHARLES F

PROJECT_TERMS: adjudication;Adult;Affect;Algorithms;Ambulatory Care;American;Ascites;care costs;Caring;Cessation of life;Child;Chronic Disease;Cirrhosis;clinically relevant;cohort;Compensation;Complex;cost;Cost Analysis;cost effective intervention;cost effectiveness;Country;Data;data repository;Data Set;demographics;Diagnosis;disability;Disease Progression;Drops;Early identification;end stage liver disease;End stage renal failure;Endoscopy;Event;follow-up;Gastrointestinal Hemorrhage;Guidelines;Health;Health Expenditures;Hepatic Encephalopathy;Hepatorenal Syndrome;high risk;Hospital Costs;Hospitalization;hospitalization rates;improved;improved outcome;indexing;Inpatients;Italy;Kidney Diseases;Knowledge;Laboratories;Life Expectancy;Life Experience;Liver;Liver Cirrhosis;Longitudinal cohort;longitudinal dataset;Methods;Modeling;Morbidity - disease rate;mortality;mortality risk;Natural History;novel;Patient Care;Patient-Focused Outcomes;Patients;perioperative mortality;Peritonitis;Persons;Pharmaceutical Preparations;Phenotype;Population;population based;predictive modeling;Preparation;Prevalence;Primary carcinoma of the liver cells;Procedures;Recommendation;Recurrence;Reporting;Research;Risk;risk prediction;risk prediction model;risk stratification;Sampling;Screening for cancer;Services;sound;Specialist;Standardization;System;Testing;Time;Transplantation;United States;Visit

PROJECT_TITLE: Natural history, risk prediction and cost of cirrhosis in insured Americans.


NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Polycystic kidney diseases (PKD) are a complex group of disorders that cause kidney failure and abnormalities in many other organs due to defects of primary cilia. Here we seek to determine the genetic causes of these diseases, correlate the particular genes and alleles involved with the disease presentation and progression, and develop cellular and whole animal models to fully characterize the diseases. Successful execution will mean a better understanding of the origins of these disease, to more precisely predict the disease courses, determine why the diseases occur, and provide clues for novel therapies.

PI_NAMEs: HARRIS, PETER C. (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Adoption;Alleles;Animal Model;Autosomal Dominant Polycystic Kidney;Autosomal Recessive Polycystic Kidney;biobank;Biological Assay;Biological Models;Body System;Brain;Carrier Proteins;Cell Separation;Cells;Cellular Assay;Chest;Cilia;ciliopathy;Clinic;cohort;Complex;Cystic kidney;Data;Defect;Development;Diagnosis;Disease;disease model;disease phenotype;disease-causing mutation;Dysplasia;End stage renal failure;Etiology;exome sequencing;Gene Dosage;gene product;Genes;Genetic;Genetic Screening;Genotype;Goals;Grant;Heterozygote;human model;improved;In Vitro;Individual;Inherited;insight;Investigation;Joubert syndrome;Kidney;Kidney Diseases;Kidney Failure;Liver;Liver diseases;LoxP-flanked allele;Meckel-Gruber syndrome;Methods;Modeling;Monitor;mouse model;mutation screening;next generation sequencing;novel therapeutics;Organ;Pathogenesis;Pathogenicity;Phenotype;Polycystic Kidney Diseases;Population;Preclinical Testing;prognostic;protein function;protein structure;protein transport;Proteins;Proteomics;rib bone structure;Role;Sampling;screening;Sensory;Severity of illness;Signaling Protein;Skeleton;System;trafficking;Variant;variant of unknown significance

PROJECT_TITLE: Investigation of common disease mechanisms in nonsyndromic and syndromic PKD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(03)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Information in the nervous system is transmitted between nerve cells at the synapse, where an electrical impulse in the “presynaptic” nerve cell causes the release of neurotransmitter from small membrane bound structures, known as synaptic vesicles. In sensory cell of the eye and inner ear the neurotransmitter, glutamate, is released from synaptic vesicles in a graded and continuous manner and deficiencies in this process may underlie hereditary forms of blindness and deafness. To aid in this process, these cells have evolved a specialized structure called a synaptic ribbon and this proposal studies the function of the structures in this process.

PI_NAMEs: THORESON, WALLACE B;ZENISEK, DAVID PAUL (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Action Potentials;Affect;Afferent Neurons;Amacrine Cells;Animal Model;Animals;Anions;Auditory system;Binding;Biological Assay;Blindness;Calcium;cell type;Cells;Charge;Communication;Coupled;Darkness;Data;deafness;Disease;Docking;Electric Capacitance;electrical property;Electrophysiology (science);Electroretinography;Excision;Exhibits;Exocytosis;experimental study;Eye;Genetic;Glutamate Transporter;Glutamates;Grant;Hair Cells;Hearing;Image;imaging study;Individual;Inherited;Inner Hair Cells;Investigation;Kinetics;knockout animal;Knockout Mice;Laboratories;Labyrinth;Location;Measures;Membrane;Membrane Potentials;Mental Depression;Mental Health;meter;Modeling;Monitor;Morphology;Movement;Multiprotein Complexes;Mus;Nervous System;Nervous System Disorder;Neurons;neurotransmission;neurotransmitter release;Neurotransmitters;Organelles;Photoreceptors;Physiological;Physiology;presynaptic;presynaptic neurons;Process;Property;Proteins;Recovery;recruit;Retina;ribbon synapse;Rod;Role;Sensory;sensory stimulus;Site;Speed;Structure;Synapses;Synaptic Transmission;Synaptic Vesicles;Testing;Transgenic Organisms;transmission process;Travel;Uncertainty;Vertebrate Photoreceptors;Vesicle;vesicular release;Vision;Visual System;voltage clamp;Zebrafish

PROJECT_TITLE: Synaptic transmission at retinal ribbon synapses

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN-M]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Robust immune responses must be delicately balanced to ensure pathogen clearance while avoiding damage to the host, as over-exuberant cytokine activity can lead to fatal diseases such as sepsis. Autophagy is a highly evolutionarily conserved cytosol-to-lysosome degradative pathway that plays diverse roles in immunity, and in preliminary studies described in this proposal was found to protect myeloid cells against cytokine-induced cell death and mice from fatal TNF-induced shock. The goal of this K08 proposal is to provide a 5-year training plan for the PI, Dr. Anthony Orvedahl, to develop the skills and resources necessary to establish a robust independent research program aimed at deciphering the mechanisms of pro-survival autophagy and the role of a novel candidate mediator of cytokine-induced death, IRG1.

PI_NAMEs: ORVEDAHL, ANTHONY W (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Aconitic Acid;Address;analog;Anti-Inflammatory Agents;antimicrobial;antiviral immunity;Autophagocytosis;Award;Biochemical;Biological Assay;Carboxy-Lyases;Cell Death;Cell Death Induction;Cell Survival;cell type;Cells;Cessation of life;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communicable Diseases;Complex;CRISPR screen;cytokine;Cytosol;Degradation Pathway;Disease;Doctor of Philosophy;Educational workshop;Enabling Factors;Ensure;Environment;Enzymes;Event;Exhibits;Future;Gene Expression Profile;Genes;genetic analysis;genome-wide;Goals;gut inflammation;Health;Homeostasis;Human;Hypersensitivity;IL18 gene;Immune;immune function;Immune response;Immunity;Immunology;Immunoprecipitation;improved;improved outcome;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;influenza infection;Institution;Interferon Type II;Interferons;K-Series Research Career Programs;Knock-out;Link;live cell imaging;Lysosomes;Macrophage;Mediating;Mediator;Medical;Medical center;medical schools;Mentors;Mentorship;Microscopic;Mitochondria;Modality;Modeling;Molecular;Molecular Genetics;Morbidity - disease rate;mortality;mouse model;Multiple Organ Failure;Mus;Myelogenous;Myeloid Cells;Neonatology;novel;Outcome;pathogen;Pathology;Pathway interactions;Patients;pediatric department;Pediatric Hospitals;Pediatrics;Physicians;Physiological;Play;prevent;Production;programs;Protein Biochemistry;Protein Kinase Interaction;Receptor-Interacting Protein;Regulation;Research;Research Personnel;Resistance;Resources;response;Role;Scientist;Sepsis;Shock;Signal Transduction;skills;systemic inflammatory response;targeted treatment;Techniques;Testing;Therapeutic;Tissues;Titrations;TNF gene;Training;Training Activity;Training Programs;Tuberculosis;Tumor Necrosis Factor Receptor;Universities;Washington;Work

PROJECT_TITLE: Role of Autophagy in Regulating Cytokine-Induced Macrophage Cell Death and Systemic Inflammatory Responses

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Disability Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Rehabilitation

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Nearly a quarter of all Americans age 65+ report serious mobility problems, and mobility problems predict greater risk of dementia; thus, preserving mobility in older age is an NIA priority. Our past work suggests that the cortical inhibitory system contributes to motor declines with aging. This proposal will test if cortical inhibition relates to individual differences in walking and balance in older age (F99) and mild cognitive impairment (K00), and whether aerobic exercise affects cortical inhibition (K00). The findings from this work could lead to the development of novel interventions to preserve mobility and prevent disability in aging and mild cognitive impairment.

PI_NAMEs: HUPFELD, KATHLEEN ELIZABETH (contact)

PROJECT_TERMS: Acute;Address;Adult;Aerobic Exercise;Affect;Age;age difference;age effect;age related;age-related disease;Aging;Alzheimer's disease risk;American;Anterior;Balance training;Biomechanics;Brain;Brain imaging;cognitive testing;Complex;Dementia;dementia risk;Deterioration;Development;disability;Disability prevention;Equilibrium;Exercise;exercise intervention;Exercise Test;fall risk;falls;Functional disorder;Functional impairment;Future;Gait;gamma-Aminobutyric Acid;Glutamates;Glutamine;Goals;Health;health goals;healthy aging;high risk;Hospitalization;human old age (65+);Impairment;improved;Individual Differences;International;Intervention;Knowledge;Link;Longevity;Lower Extremity;Magnetic Resonance Spectroscopy;Measures;Mediating;Mentorship;Methods;mild cognitive impairment;Mobility decline;Mobility disability;mortality;Motor;motor control;motor impairment;motor symptom;Movement;Muscle;Muscle Contraction;Neurobehavioral Manifestations;Neurosciences;Neurotransmitters;novel;older adult;Outcome;Performance;Postdoctoral Fellow;Posture;preservation;Process;programs;Quality of life;Reporting;Research;Research Personnel;Research Project Grants;response;restoration;Skeletal Muscle;Specificity;Structure;System;Testing;therapy development;Training;Transcranial magnetic stimulation;Upper Extremity;Walking;Work;young adult

PROJECT_TITLE: Cortical Inhibition and Mobility in Older Adults


NIH_SPENDING_CATS: Bioengineering;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Outcomes following hematopoietic stem cell transplantation for treatment of blood disorders and hematologic malignancies are limited by the availability and quality of donor-matched sources of bone marrow, mobilized peripheral blood, and cord blood. To date, efforts to expand hematopoietic stem cells in culture and develop alternative sources of stem cells have resulted in relatively poor self-renewal, skewed lineage potential, or low engraftment efficiencies. The goal of the current research is to leverage new knowledge supporting an executive role for mitochondrial remodeling in acquisition of hematopoietic fate in the embryo to establish new methods for engineering scalable sources of hematopoietic stem cells that possess long-term, multi-lineage engraftment potential.

PI_NAMEs: WENZEL, PAMELA LYNN (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Address;Adult;age related;Allogenic;Architecture;Arterial Lines;Bioenergetics;Biological Assay;Biomechanics;Biomimetics;Biophysics;Blood flow;blood treatment;Bone Marrow;Cardiac;Cardiac Myocytes;Cells;Coculture Techniques;Crista ampullaris;Cues;Cyclosporine;Data;Data Set;defined contribution;design;Development;directed differentiation;disease model;druggable target;Embryo;Embryonic Heart;Endothelial Cells;Endothelium;energy efficiency;Energy Metabolism;Engineering;Engraftment;Exhibits;Frequencies;Funding;Generations;Genetic;Goals;Heart;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic Cell Production;hematopoietic differentiation;hematopoietic gene;hematopoietic stem cell emergence;hematopoietic stem cell expansion;hematopoietic stem cell fate;hematopoietic stem cell formation;Hematopoietic Stem Cell Specification;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;hemogenic endothelium;Homing;improved;in utero;In Vitro;inhibitor;insight;Interruption;Knowledge;Maintenance;Measures;Mediating;Membrane;Membrane Potentials;Metabolic;Metabolism;Methods;Mitochondria;mitochondrial membrane;mitochondrial permeability transition pore;Modeling;Modification;Molecular;Morphology;mutant;mutant mouse model;novel;Organelles;Outcome;Output;Oxidative Phosphorylation;Oxygen Consumption;Patients;peripheral blood;pharmacologic;Phase;Phenotype;Preparation;Process;progenitor;Proteins;Reactive Oxygen Species;reconstitution;recruit;Regulation;Regulatory Element;Reporting;Research;Resolution;Role;self-renewal;shear stress;Signal Transduction;single-cell RNA sequencing;Site;solute;Source;Specific qualifier value;stem cells;Structure;Superoxides;Testing;Therapeutic;Therapeutic Uses;transcriptome;Transplant-Related Disorder;Umbilical Cord Blood;Work

PROJECT_TITLE: Biomechanical Determinants of Hematopoietic Stem Cell Potential

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Bioengineering;Cancer;Colorectal Cancer;Digestive Diseases;Patient Safety

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The United States performs more robotic surgery than all other countries combined. However, it’s adoption across an increasingly broad range of procedures may be problematic for patients caught between enthusiasm for new technology and a lack of rigorous evidence to support these changes in practice. This proposal will provide patients, providers, and policymakers with real-world estimates on the adoption of robotic surgery, in addition to its short- and long-term outcomes compared to more established approaches (e.g. laparoscopic surgery) for the most common general surgery procedures.

PI_NAMEs: DIMICK, JUSTIN BRIGHAM (contact)

PROJECT_TERMS: Adoption;Anatomy;cancer surgery;care episode;Cholecystectomy;Clinical;Clinical Data;clinical practice;Colon Carcinoma;colon surgery;comparative;comparative safety;Complication;cost;Country;Data;Decision Making;design;Diffusion;Effectiveness;Ensure;evidence base;Expenditure;experience;Goals;Growth;Health Expenditures;Hernia;Heterogeneity;Hospitals;improved;Incidence;Inguinal Hernia;interest;Laparoscopic Surgical Procedures;Learning;Medical;Medicare;new technology;Observational Study;operation;Operative Surgical Procedures;Outcome;Patient Selection;Patients;Perioperative;Policy Maker;population based;Postoperative Complications;Privatization;Procedures;Professional Organizations;Provider;randomized trial;Records;Rectal Cancer;Recurrence;repaired;Reporting;Risk;robotic system;Robotics;Safety;Selection Bias;skills;standard of care;Surgeon;System;Technology;Time trend;treatment effect;trend;United States;Variant;Ventral Hernia;Work

PROJECT_TITLE: Rapid Adoption of Robotic Surgery: Risks, Benefits, and Unintended Consequences

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Infectious Diseases

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

PHR: Narrative The proposed research is expected to explain the biophysical principles by which Helicobacter pylori, which cause gastric cancers and peptic ulcers, migrate towards favorable chemical habitats to establish colonies. In the proposed work, we will pioneer the use of novel biophysical methods to determine the molecular mechanisms of bacterial migration. Fundamental insights from our work will likely help develop novel strategies to prevent H. pylori infections of the stomach.

PI_NAMEs: LELE, PUSHKAR PRAKASH (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Adaptor Signaling Protein;Address;Anti-Bacterial Agents;antibiotic resistant infections;Bacteria;Biological Assay;Biophysical Process;biophysical techniques;Biophysics;cell motility;Cells;Chemicals;Chemoreceptors;Chemotaxis;Chemotaxis Inhibition;Chimeric Proteins;Coupling;Data;desensitization;Detection;Development;Dose;Environment;Enzymes;Escherichia coli;experimental study;extracellular;Flagella;Fluorescence Resonance Energy Transfer;Goals;Habitats;Helicobacter Infections;Helicobacter pylori;Homologous Gene;Imaging Techniques;Individual;Infection;Inflammation;innovation;insight;Knowledge;laser tweezer;Ligands;Literature;Location;malignant stomach neoplasm;Mastigophora;Measures;Mediating;Methods;Microscopy;migration;Modeling;Molecular;Motility;Motor;novel;novel strategies;optic tweezer;Outcome;Output;Pattern;Peptic Ulcer;Phase;Phosphotransferases;Play;Population;prevent;Prognosis;protein-histidine kinase;Proteins;receptor;receptor function;Research;response;Role;Rotation;Running;Signal Transduction;simulation;Source;Standard Model;Stomach;Swimming;Techniques;Testing;Work

PROJECT_TITLE: Biophysical determinants of chemotaxis in Helicobacter pylori

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-F(02)M]


NIH_SPENDING_CATS: Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: Project Narrative African Americans have 6-fold higher prevalence for carrying an H. pylori Infection. We discovered that an African-centric S47 variant of the cancer suppressor gene - TP53 causes macrophages to engage an anti- inflammatory response to bacterial infections. In this proposal, we will describe the mechanism by which the S47 SNP causes disparities in H. pylori infection, test therapeutic avenues with focus on LXR agonists to reverse the macrophage anti-inflammatory phenotype and reduce the disparity in H. pylori infection.

PI_NAMEs: CLAIBORNE, DANIEL THOMAS (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Acute;Address;Affect;African;African American;African American population;African ancestry;Agonist;Alleles;Amino Acids;Anti-Bacterial Agents;Anti-Inflammatory Agents;ARG2 gene;arginase;Asian population;Avena sativa;Bacteria;Bacterial Infections;bead chip;Binding;Biological;Bone Marrow;Caucasians;Cells;Chronic;chronic infection;Clinical;Code;Cohort Studies;Communication;Communities;Data;Disparity;disparity reduction;DL-alpha-Difluoromethylornithine;DNA;Dysplasia;East Asian;efficacy testing;Energy Metabolism;Environment;European;exome;extracellular;Fatty Liver;FRAP1 gene;FTH1 gene;Gastric Intraepithelial Neoplasia;Gastritis;Genes;Genetic Polymorphism;genetic variant;genome-wide;Genus Mycobacterium;Glycolysis;Goals;health disparity;Helicobacter Infections;Helicobacter pylori;High Prevalence;high risk;Hispanic Populations;Human;Immune;immune cell infiltrate;Immune response;improved;improved outcome;Incidence;Individual;Infection;Inflammation;Inflammatory Response;inhibitor;Innate Immune Response;Iron;Iron Overload;Length;Listeria;Liver X Receptor;low socioeconomic status;Macrophage;Macrophage Activation;Maps;Messenger RNA;Metformin;Minority;Modeling;Molecular;mouse model;Mucin 1 protein;Mucous Membrane;multi-ethnic;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;new therapeutic target;Not Hispanic or Latino;NOTCH1 gene;novel therapeutics;Outcome;Paper;Pathogenesis;Pathway interactions;Peroxisome Proliferator-Activated Receptors;personalized medicine;Persons;Phenotype;Polyamines;Population;Prevalence;Productivity;Proteins;Proteomics;racial difference;receptor;Receptor Activation;Regulation;Reporting;Research Design;response;Role;Sampling;seropositive;Socioeconomic Status;socioeconomics;Stomach;synergism;Testing;Therapeutic;therapeutic evaluation;Therapeutic Studies;Tissues;TLR1 gene;TLR3 gene;TLR7 gene;TP53 gene;Tumor Suppressor Genes;Variant;Virulence;Virulence Factors

PROJECT_TITLE: Role of African-centric TP53 variant in higher H. pylori prevalence in African Americans


ADMINISTERING_IC: AT

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Dietary Supplements;Natural Products;Nutrition;Patient Safety

ORG_CITY: Auburn

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: PROJECT NARRATIVE Botanical dietary supplements are consumed more by cancer patients than otherwise healthier patients without cancer. However, using botanical dietary supplements in combination with anticancer drugs can lead to life- threatening drug interactions. Our group has reason to believe that botanical dietary supplements containing açaí can cause these adverse events when taken with anticancer drugs that are metabolized by a certain liver enzyme.

PI_NAMEs: HECK, KABRE  (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Adverse event;Anthocyanins;Antineoplastic Agents;assay development;Baculoviruses;bioactive natural products;Biological;Biological Assay;Blood Vessels;Botanical dietary supplements;Botanicals;cancer diagnosis;Cancer Patient;cancer therapy;Cardiotoxicity;cardiovascular risk factor;Cardiovascular system;career;Cause of Death;Cells;Cessation of life;chemical fingerprinting;Chemicals;chemotherapeutic agent;chemotherapy;clinically relevant;Collaborations;Complement;Complex;Consumption;Coupled;CYP3A4 gene;dashboard;Data;Data Set;Database Management Systems;Development;Drug Interactions;Drug Prescriptions;Educational process of instructing;Enzyme Kinetics;Enzymes;Ethanol;Euterpe;Evaluation;Excretory function;experience;Experimental Designs;experimental study;Faculty;Fruit;Glucosides;Glucuronosyltransferase;Health;Hepatic;Human;hydrophilicity;In Vitro;inhibitor;Insecta;Institution;Kidney;Knowledge;Laboratories;Letters;Life;lipophilicity;Literature;Liver;Malignant Neoplasms;Mass Spectrum Analysis;member;Mentorship;Metabolic Biotransformation;Metabolism;Methanol;Molecular;National Center for Complementary and Integrative Health;Natural Products;Outcome;Patients;Pharmaceutical Preparations;Phase;predictive tools;Principal Investigator;Probability;programs;protective effect;Protein Isoforms;Quality of life;Recombinants;Reporting;Research;Research Personnel;Resolution;Review Literature;Risk;seal;side effect;skills;social;Source;Standardization;Substrate Specificity;Techniques;Testing;Time;tool;Toxic effect;Training;Transfection;Translations;United States;United States Food and Drug Administration;United States National Institutes of Health;Validation;Water;Work

PROJECT_TITLE: Evaluation of Euterpe oleracea Mart. (açaí) for inhibition of UGTs as a mechanism of botanical-drug interactions involving anticancer drugs


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Nutrition;Orphan Drug;Prevention;Rare Diseases

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Hepatic glycogen accumulation associated with elevated serum levels of liver enzymes, liver fibrosis and cirrhosis is one complication of urea cycle disorders. We will investigate the biochemical basis of hepatic glycogen deposition in urea cycle disorders and test whether a reduction of hepatic glycogen levels leads to improvement in liver disease in urea cycle disorders. The insights from this work have the potential to impact the care of patients with urea cycle disorders and may also elucidate a broader mechanism that contributes to hepatic glucose output and glycogen storage in more common diseases.

PI_NAMEs: BURRAGE, LINDSAY C (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Acetylation;Address;Adenoviruses;Alpha-glucosidase;Ammonia;Argininosuccinate lyase deficiency;Biochemical;Birth;Chronic;chronic liver disease;Cirrhosis;Citrullinemia;comorbidity;Complication;Data;Deposition;Diabetes Mellitus;diabetic;Disease;Distal;Early Diagnosis;Energy Metabolism;enzyme activity;Enzymes;extend lifespan;Functional disorder;Generations;genetic manipulation;Genetic Transcription;Glucose;Glucose Metabolism Disorders;glucose output;Glycogen;Glycogen (Starch) Synthase;glycogen metabolism;Glycogen Phosphorylase;glycogenolysis;Growth;Hepatic;Hepatic Tissue;Hepatomegaly;Hereditary Disease;High Prevalence;Human;human tissue;Hyperammonemia;Impairment;improved;Individual;Infant;insight;Life;life span;Link;Liver;Liver Cirrhosis;Liver diseases;Liver Dysfunction;Liver Fibrosis;Liver Glycogen;liver metabolism;Metabolic;Modeling;mouse model;Mus;Mutant Strains Mice;Natural History;Nitrogen;novel;novel therapeutic intervention;Pathology;Patient Care;Patients;Phosphorylation;Post-Translational Protein Processing;Prevalence;prevent;Primary carcinoma of the liver cells;Protein-Restricted Diet;Proteins;Regulation;Serum;stable isotope;targeted treatment;Testing;Therapeutic;therapeutic target;Tissues;Transaminases;United States;urea cycle;Urea cycle disorders;Virus;Work

PROJECT_TITLE: DISSECTING THE LINK BETWEEN UREAGENESIS AND HEPATIC GLYCOGEN METABOLISM

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Microbiome

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Narrative C. difficile is a CDC “Urgent Antibiotic Resistance Threat” as the number one hospital-acquired infection in North America. Current therapy with antibiotics is inadequate, as relapse occurs in up to 20% and death in 6%. The proposed studies, by identifying how innate immunity protects, offer the promise of immunotherapy as an addition to current approaches to treatment and as a replacement for fecal transplant to prevent relapse.

PI_NAMEs: PETRI, WILLIAM A (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Acute;Adoptive Transfer;Amphiregulin;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;arginase;Bacteria;Bioinformatics;cell type;Cells;Cessation of life;Church;Clostridium difficile;commensal microbes;conditional knockout;cytokine;dysbiosis;Effector Cell;eosinophil;Epidemic;Epithelium;experimental study;fecal transplantation;Flow Cytometry;Foundations;gastrointestinal epithelium;Goblet Cells;gut microbiota;healing;Human;Human Resources;Immune;Immune system;Immunity;Immunotherapy;Individual;Infection;Inflammation;innovation;Interleukin-10;Interleukin-13;Interleukin-4;Interleukin-5;Intervention Studies;intestinal epithelium;Intestines;Knowledge;Lymphoid Cell;Macrophage;macrophage product;Mediating;microbiota;Modeling;mouse model;Mucous body substance;Mus;Natural Immunity;North America;Nosocomial Infections;Phenotype;prevent;Process;Production;professional atmosphere;receptor;Relapse;relapse prevention;Research;Research Personnel;Resolution;response;Role;Signal Transduction;single-cell RNA sequencing;Systems Biology;Testing;Time;TLR2 gene;Toxin;transcriptomics;Transferase;Virulence;Walking;Weight Gain

PROJECT_TITLE: Role of Type 2 Immunity in Innate Protection from C. difficile

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-S(02)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eczema / Atopic Dermatitis;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Infectious Diseases;Patient Safety;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative: Dermatology has experienced the emergence of targeted immuno-modulating drugs that have unprecedented efficacy in treating recalcitrant atopic dermatitis. We will generate directly applicable clinical insights on the safe and targeted use of new immuno-modulating drugs to treat AD by leveraging existing claims data sources with added EHR data and using novel methods for causal inference. The expedited evidence generation via the proposed prospective monitoring system will efficiently close knowledge gaps for optimal IMD use in patients with AD, including underrepresented and high-risk patients.

PI_NAMEs: SCHNEEWEISS, SEBASTIAN G. (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Address;Adverse effects;Age;Algorithms;American;Atopic Dermatitis;Bacterial Infections;beneficiary;Calibration;Child;child bearing;chronic inflammatory skin;Clinical;clinical application;clinical decision support;clinical decision-making;clinical practice;cohort;comorbidity;comparative safety;Complement;Complex;COVID-19;cytokine;Data;Data Analyses;data mining;Data Sources;Databases;Dermatologist;Dermatology;design;Development;Disease;drug market;Drug usage;economic indicator;Electronic Health Record;Ethnic Origin;Event;Exclusion;experience;Exposure to;flu;follow-up;Future;Generations;Health;Healthcare;high risk;Immune;immune function;immune modulating agents;Immunologics;Immunosuppression;improved;Infection;infection risk;inhibitor;innovation;insight;Investigation;Knowledge;Link;longitudinal analysis;Malignant Neoplasms;Marketing;Medicaid;medication safety;Methods;Minority Groups;Minority Women;Modernization;Modification;Monitor;Morbidity - disease rate;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;novel strategies;off-label use;older adult;Opportunistic Infections;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;personalized medicine;Pharmaceutical Preparations;Pharmacoepidemiology;placebo controlled trial;Placebos;Play;Population;population based;Predisposition;Pregnant Women;prior authorization;Production;prospective;Quality of life;Race;racial minority;real time monitoring;Reproducibility;reproductive;Research;Residual state;Risk;Risk Factors;Risk-Benefit Assessment;Safety;Scanning;Seasons;side effect;Signal Transduction;skin disorder;socioeconomics;Source;standard care;Subgroup;System;targeted treatment;Testing;Time;treatment choice;trend;Uncertainty;Underrepresented Minority;Underrepresented Populations;Update;Variant;Venous;venous thromboembolism;viral epidemic;Virus Diseases;Woman;young woman

PROJECT_TITLE: New approaches to safety monitoring of novel systemic treatments for atopic dermatitis in clinical practice and underrepresented populations


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The degeneration of retinal ganglion cells (RGCs) has been linked to several devastating blinding diseases. Based on our previous work on Armcx1 that revealed its capacity to promote RGC repair after a traumatic injury we will investigate its role in chronic neurodegenerative diseases and axonal outgrowth.

PI_NAMEs: GOSPE, SIDNEY M (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Acute;Affect;arm;Armadillo Repeat;Axon;axon growth;axon regeneration;Binding;Biology;Cell Survival;Chronic;Chronic Disease;Cytosol;Data;Development;Disease;disease model;Down-Regulation;Elements;Etiology;Functional disorder;Goals;Impairment;in vivo;innovation;Intervention;knock-down;Knowledge;Length;Link;link protein;Mass Spectrum Analysis;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular Conformation;Natural regeneration;Nerve Crush;Nerve Degeneration;Neurodegenerative Disorders;neuronal cell body;Neurons;neuroprotection;novel;Optic Nerve;optic nerve disorder;Optic Nerve Injuries;Outer Mitochondrial Membrane;overexpression;Pathologic;Pathology;Pharmacologic Substance;Phase;Physiological;Play;Process;programs;protein protein interaction;Proteins;proteomic signature;Regulation;repaired;Research;Retinal Diseases;retinal ganglion cell degeneration;Retinal Ganglion Cells;Role;Stress;Testing;Therapeutic;Traumatic injury;Vision Disorders;Work

PROJECT_TITLE: Regulation of the retinal ganglion cell repair program by the mitochondrial protein Armcx1

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Endocrine Disruptors;Foodborne Illness;Nutrition;Pediatric;Social Determinants of Health

ORG_CITY: College Station

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

PHR: NARRATIVE Using edible sorbents to reduce population exposures to PFAS from contaminated food and water at the site of emergencies is a novel and practical approach. The integration of in vitro, in silico, and in vivo assays will be used to collectively characterize and validate multicomponent sorbents that are effective in reducing PFAS exposures.

PI_NAMEs: WANG, MEICHEN  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Adsorption;Affinity;Amendment;Animals;Benign;Binding;Biochemistry;Biological Assay;Biological Availability;Birth Weight;Blood;Blood specimen;Body Weight;Cell model;Cells;Chemicals;Chemistry;clay;Clinical;Communities;comparative efficacy;Complement;Complex;computational chemistry;computer studies;Consumption;contaminated drinking water;Data;data-driven model;Development;Diet;dietary;Dose;dosimetry;drinking water;Drug Metabolic Detoxication;efficacy validation;Emergency Situation;Environment;environmental chemical;Environmental Pollutants;Event;exposed human population;exposure route;Exposure to;Female;Fire - disasters;first responder;Floods;Food;Food Contamination;Frequencies;Frontline worker;Gastrointestinal tract structure;Goals;Half-Life;Health;Human;Human Milk;Hurricane;immunotoxicity;in silico;In Vitro;in vitro Assay;in vivo;in vivo evaluation;Industrialization;Infant;Infertility;Ingestion;Inhalation Exposure;Intervention;Intestines;Kinetics;Legal patent;Licensing;Low Birth Weight Infant;male;Malignant neoplasm of testis;Mammalian Cell;Methods;Microbe;Micronutrients;Modeling;molecular dynamics;Montmorillonite;Mycotoxins;novel;Nutrient;Oral;Organ;Organism;Outcome;Partner in relationship;Pathway interactions;Phase;Poly-fluoroalkyl substances;Population;pregnant;Prevalence;Process;Rattus;Reaction;remediation;Renal Carcinoma;Reporting;Research;Safety;safety study;screening;simulation;Site;skills;Soil;Stomach;substance use;Surface;System;Testing;Therapeutic;Thermodynamics;Time;Toxic effect;uptake;Urine;Vulnerable Populations;Water;Work

PROJECT_TITLE: Development of edible sorbent therapies to mitigate dietary exposures to per- and polyfluoroalkyl substances (PFAS)