ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE  The research team will work with providers, staff, management and patients at Cherokee Nation Health Services to culturally adapt and evaluate Counseling for Harm Reduction and Retention in MAT with Cherokee Nation (CHaRRM-CN). In the short-term, this project is positioned to make a strong, individual-level impact by increasing MAT retention, reducing substance-related harm and illicit opioid use, and increasing Native enculturation. This project may have a broader impact on public health by reducing substance-related harm and associated strain on publicly funded services.

PI_NAMEs: COLLINS, SUSAN E;GASSAWAY, ASHLEY ;NELSON, LONNIE A. (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: 2 arm randomized control trial;Abstinence;Address;American Indians;Biochemical;Cherokee Nation;Cognitive Therapy;Communities;community advisory board;comparative efficacy;comparison control;Counseling;Data;Death Rate;Development;efficacy testing;Emergency department visit;Evaluation;evidence base;experience;flexibility;Focus Groups;follow-up;Foundations;Funding;General Population;Goals;Harm Reduction;Health Services;Health system;High Prevalence;illicit opioid;improved;Individual;Interview;Length;Manuals;marginalized population;Medical;medication-assisted treatment;Methods;mortality;National Institute of Drug Abuse;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose death;Overdose reduction;Participant;patient oriented;Patient Self-Report;Patients;Phase;Positioning Attribute;primary outcome;Professional counselor;programs;Provider;Proxy;Public Health;Recommendation;Relative Risks;Research;Research Methodology;Research Personnel;response;retention rate;secondary outcome;self reliance;Services;services as usual;Suboxone;substance use;Substance Use Disorder;substance use treatment;systematic review;treatment as usual;Treatment outcome;treatment program;tribal community;United States Substance Abuse and Mental Health Services Administration;Universities;Washington;Work

PROJECT_TITLE: Counseling for Harm Reduction and Retention in Medication-assisted treatment - Cherokee Nation (CHaRRM-CN)


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Childhood Obesity;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Nutrition;Obesity;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PUBLIC HEALTH STATEMENT The childbearing years are a critical life stage for weight gain and long-term cardio-metabolic health in women, but they are also a key time when interventions (indoor air filtering, stress reduction, or diet changes) can be implemented effectively. If successful, our work will motivate pregnancy-directed interventions that may help millions of women to prevent lifelong changes in body weight and related adverse health consequences.

PI_NAMEs: COLICINO, ELENA  (contact);WU, HAOTIAN

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: adipokines;Affect;Air;air filter;Air Pollution;Anthropometry;Atherosclerosis;Biological Markers;Blood;Blood Glucose;Blood Pressure;Body fat;Body mass index;Body Weight;C-reactive protein;cardiometabolism;Carotid Atherosclerotic Disease;carotid intima-media thickness;causal model;Child;child bearing;Child Health;Circulation;Cities;cost;Data;Development;Diet;Diet Habits;Dietary Questionnaires;Early identification;Encapsulated;Environment;Environmental Exposure;Event;experience;extracellular vesicles;Fasting;fetal programming;Fetus;fine particles;follow-up;Future;Grant;Growth;Health;High Density Lipoprotein Cholesterol;high risk population;Hip region structure;Hydrocortisone;hypothalamic-pituitary-adrenal axis;indoor air;Inflammatory;inflammatory marker;Insulin Resistance;Intervention;Joints;late life;Life;Life Cycle Stages;Life Experience;Life Stress;Link;Lipids;Longitudinal Studies;maternal obesity;maternal outcome;maternal weight;Measures;Mediator;Mental Depression;Metabolic;Metabolism;metabolome;metabolomics;Mexico;microRNA biomarkers;MicroRNAs;Mothers;nanosized;Obesity;obesity risk;Organ;Orosomucoid;Outcome;particle;Particulate;Pathway interactions;Pattern;Physiological;Placenta;placental trophoblasts;Plasma;Pollution;post pregnancy;Postpartum Period;Predisposition;Pregnancy;Pregnancy Trimesters;prevent;Process;programs;Psychosocial Stress;Public Health;recruit;Research;Resources;Risk Factors;RNA;Role;Salivary;Sampling;Second Pregnancy Trimester;Signal Transduction;social stressor;Stress;stress reduction;Testing;Time;Tissues;Triglycerides;ultrasound;vesicular release;Violence;Weight;Weight Gain;Woman;Women's Health;Work

PROJECT_TITLE: Air Particulate Pollution and Stress: Effects and Mechanisms for Long-term Maternal Obesity Risks


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Drug Abuse (NIDA only);Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Psychosis;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Visual representations of complicated visual scenes rely on flexible normalization, which allows past experience and scene context to determine which visual features are enhanced and which are suppressed. Flexible normalization is accomplished by fine-tuned regulation of local inhibitory neuron populations; failed regulation of these inhibitory pools is implicated in perceptual deficits associated with psychosis. The proposed work will combine 2-photon imaging in primary visual cortex of ferrets with computational modeling to provide a quantitative link between specific visual behaviors and corresponding neuronal sub-population activity; this link, in turn, can guide research into improved treatments for illnesses such as schizophrenia and bipolar disorder.

PI_NAMEs: OLMAN, CHERYL A.;SEDERBERG, AUDREY ;SMITH, GORDON BRAWN (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Anesthesia procedures;area striata;Articulation;Behavior;Bipolar Disorder;Brain;Cells;Cognitive Therapy;Complex;Computer Models;Data;Development;Event;experience;experimental study;Ferrets;flexibility;Frequencies;Grouping;Human;Image;Imaging Techniques;improved;in silico;in vivo;Individual;inhibitory neuron;insight;Interneurons;Knowledge;Link;Literature;luminance;Maps;Measures;Mediating;Modeling;Modification;Morphology;mouse model;Mus;network models;neural;neural circuit;neuromechanism;Neurons;novel;open source;orientation columns;orientation selectivity;Parvalbumins;Perception;Perceptual disturbance;Physical environment;Population;Positioning Attribute;Primates;Probability;Property;Psychoses;Publishing;receptive field;Recurrence;Regulation;Research;response;Role;Schizophrenia;Series;Serotonin;Somatostatin;stellate cell;Stimulus;Structure;Testing;Texture;theories;Therapeutic Agents;two-photon;Visual;Visual Cortex;Visual Perception;visual stimulus;Weight;Work

PROJECT_TITLE: Flexible normalization in ferret V1: computational modeling and 2-photon imaging


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: CLEVELAND

ORG_DEPT: DENTISTRY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Narrative: People living with HIV (PLWH) are at higher risk for oral warts and head and neck cancer due primarily to higher incidences of human papilloma virus (HPV) infections that are contracted orally by compromised cells in the lining of the mouth. Our research has shown that these cells are epigenetically modified, i.e., that either chronic HIV infection and/or the antiretroviral therapy- is/are altering certain genes without altering their DNA. By identifying these alterations, determining their effect on gene expression and seeing if they contribute to increased risk of HPV infection, we will drive the discovery and application of novel epigenomic-based clinical interventions in PLWH.

PI_NAMEs: WEINBERG, AARON  (contact);ZWOLINSKA, KATARZYNA

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Address;Age;age related;antiretroviral therapy;ATAC-seq;Benign;Bioinformatics;Biological Assay;Biopsy;Cancer Detection;Cardiovascular Diseases;cell age;Cell Separation;Cells;Cellular biology;Cellular Stress;Chromatin;Chronic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collecting Cell;Contracts;COVID-19;Data;Data Set;differential expression;Disease;DNA;DNA Modification Methylases;epigenetic marker;Epigenetic Process;epigenome;epigenomics;Epithelial Cells;Epithelium;Event;Exhibits;Functional disorder;Future;Gene Expression;General Population;Genes;Genetic;genome-wide;Genomics;Goals;guided inquiry;Head and Neck Cancer;Health;Health Care Costs;high risk;Histone Deacetylase;HIV;HIV Infections;HIV Seronegativity;HIV/AIDS;Human;Human papilloma virus infection;Human Papillomavirus;Human papillomavirus 16;Immune;improved;In Vitro;in vivo;Incidence;Individual;Infection;Innate Immune Response;Intervention;keratinocyte;Life Cycle Stages;Life Expectancy;Liver diseases;lonely individuals;malignant mouth neoplasm;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Methods;microbial;Modeling;Molecular;Mouth Carcinoma;Mouth Diseases;mouth squamous cell carcinoma;Netherlands;neurocognitive disorder;novel;Oral;Oral cavity;oral cavity epithelium;Oral health;oral HIV;oral infection;Oral mucous membrane structure;Oral Pathology;oral wart;Oropharyngeal;Osteoporosis;Pathway interactions;Patients;Periodontal Diseases;permissiveness;Persons;Predisposition;Proteome;Proteomics;Quality of life;Race;Reproducibility;Research;Risk;Risk Reduction;Sampling;Secondary to;sex;small hairpin RNA;small molecule;stem;System;Techniques;Testing;Therapeutic Studies;Tissues;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;Treatment-related toxicity;Viral;virology;Virus Diseases

PROJECT_TITLE: Epigenetics of dysfunctional oral epithelium in people living with HIV and risk for HPV infection

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The human major histocompatibility complex (MHC) and the killer cell immunoglobulin-like receptor (KIR) regions encode multiple, interacting components of immunity. Their genetic diversity is associated with a wide range of immune-mediated diseases and transplantation outcome. In this project we will study the impact of genetic variation in these region on the development and severity of asthma, a chronic inflammatory disease of the lungs that is increasing in prevalence, currently affecting over 30 million Americans, and that exhibits disparities across the populations of this country.

PI_NAMEs: NORMAN, PAUL JOHN (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Acceleration;adaptive immunity;Affect;African American;African ancestry;Algorithms;Alleles;Allergic Disease;allergic response;American;Amerindian;Antibody Formation;arm;Asthma;Atopic Dermatitis;Autoimmune;Autoimmune Diseases;Bioinformatics;bioinformatics pipeline;causal variant;Cell Physiology;Cell-Mediated Cytolysis;Cells;Cessation of life;Child;Chromosome 19;Chromosome 6;Chronic;chronic inflammatory lung disease;cohort;combinatorial;Communicable Diseases;Complex;cost effective;cost estimate;Country;Data;design;Development;Disease;Disease Resistance;Disparate;Disparity;DNA;Education;European;Exhibits;Extrinsic asthma;Family;flexibility;Frequencies;Genes;Genetic;Genetic Polymorphism;Genetic Variation;genome-wide;Genomic Segment;Genomics;Genotype;Goals;Graph;Haplotypes;Health;Hematopoietic Stem Cell Transplantation;Heterozygote;High Prevalence;Hispanic;Histocompatibility Antigens Class I;Histocompatibility Antigens Class II;HLA Antigens;Homozygote;Human;Human Genome;Hypersensitivity;IgE;Immune;Immune response;Immunity;Immunoglobulins;Immunologics;Incidence;Individual;Infection;Inflammatory;insight;Intervention;Killer Cells;Knowledge;Link;Major Histocompatibility Complex;Major Histocompatibility Complex Gene;Measures;Mediating;Medical;Methodology;Methods;Natural Immunity;Natural Killer Cells;Nature;novel;Outcome;pathogen;Pathway interactions;Patients;Population;Population Group;Predisposition;Pregnancy;pressure;Prevalence;Production;Prognosis;Property;Proteins;receptor;Receptor Cell;Reproduction;reproductive success;Resolution;Respiratory physiology;response;Role;Serum;Severities;Signal Transduction;Specificity;Structure;Study Subject;Syndrome;T-Lymphocyte;targeted sequencing;Testing;tool;Transplantation;user-friendly;Variant;Work

PROJECT_TITLE: Insights Into Immune-Related Diseases Born from Population Genomics


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative Glycosaminoglycans are linear polysaccharides that are expressed on all animal cells and play a key role in cell homeostasis and have been implicated in many human diseases, including cancer, pathogen infection, and developmental disorders. This proposal describes strategies utilizing functional genomics, biochemical techniques, and proteomics to determine the molecular mechanisms that control glycosaminoglycan assembly, which are virtually unknown. Regulatory mechanisms identified in these studies will shed light on the biosynthesis of these complex carbohydrates in normal physiology and disease states and may provide novel therapeutic targets for human disorders.

PI_NAMEs: WEISS, RYAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Anabolism;Animals;Binding;Binding Sites;Biochemical;Biogenesis;Carbohydrates;Cell Physiology;Cell surface;cell type;Cells;Cellular biology;Chromatin Remodeling Factor;Complex;Core Protein;Development;developmental disease;Disease;Endoplasmic Reticulum;Enzymes;Epigenetic Process;Extracellular Matrix;Family;functional genomics;Genetic Transcription;Glucosamine;Glycobiology;Glycosaminoglycans;glycosylation;Goals;Golgi Apparatus;Growth Factor;Homeostasis;Human;human disease;In Situ;Infection;Interdisciplinary Study;interest;Knowledge;Ligand Binding;Location;Malignant Neoplasms;Mammalian Cell;member;Modification;Molecular;Molecular Chaperones;new therapeutic target;novel;Organ;pathogen;Pathway interactions;Physiology;Play;Polycomb;Polysaccharides;Process;programs;Property;protein protein interaction;Proteoglycan;proteoglycan core protein;Proteomics;Regulation;Research;Role;scaffold;Scaffolding Protein;Signal Transduction;Specific qualifier value;Structure;sugar;Sugar Acids;Sulfate;Techniques;Tissues;transcription factor;Uronic Acids;virtual;Work

PROJECT_TITLE: Investigating the molecular mechanisms of glycosaminoglycan assembly

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Head and neck squamous cell carcinomas (HNSCCs) are an aggressive form of cancer which are difficult to treat due to the complexity and heterogeneity of the tumors among patients. Here we aim to develop a highly reliable cancer modeling approach with patient-derived tumor organoids of HNSSC, screen them with clinical radiotracers and compare with patient data from the clinic. This strategy will allow us to measure the sensitivity to standard-of-care treatments for individual HNSCC subtypes based on their epigenetic signatures and pave a way to develop an effective and precision therapy for HNSCC treatment.

PI_NAMEs: KHAN, SYAMANTAK  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Accounting;analysis pipeline;anti-cancer research;automated image analysis;Automation;Biological;Biological Assay;bioprinting;cancer imaging;Cancer Model;cancer subtypes;career development;Classification;Clinic;Clinical;clinical biomarkers;Clinical Data;clinical decision-making;clinical imaging;clinically relevant;Collaborations;Combined Modality Therapy;Data;DNA;DNA Methylation;drug candidate;Drug resistance;Drug Screening;drug testing;effective therapy;Ensure;Epigenetic Process;Flow Cytometry;fluorodeoxyglucose;Future;Generations;Genetic;Genetic Markers;Genome;Goals;Grant;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Heterogeneity;high throughput screening;Histology;HPV positive;Hypermethylation;Image;imaging biomarker;Immune;immune activation;Immunotherapy;improved;Individual;innovation;Knowledge;Link;Malignant neoplasm of salivary gland;Malignant neoplasm of thyroid;Malignant Neoplasms;Measurement;Measures;Mentors;Messenger RNA;Metabolic;metabolome;Methodology;Methylation;methylation pattern;Microscopy;Mission;Modeling;Nature;novel;novel therapeutics;Organoids;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phenotype;Play;Population;Positron;Positron-Emission Tomography;Precision therapeutics;Prediction of Response to Therapy;preservation;prospective;Radiation;radiation response;Radiation therapy;Radioactive Iodine;Radioisotopes;radiotracer;Recurrence;Recurrent disease;Refractory;Research Design;Resistance;Resolution;response;screening;segregation;self assembly;skills;Solid Neoplasm;Speed;standard of care;Standardization;Subgroup;Survival Rate;Technology;therapy resistant;time use;Tissues;transcriptome;Translating;treatment planning;Treatment Protocols;treatment response;tumor;tumor heterogeneity;tumor molecular fingerprint;tumor-immune system interactions;United States National Institutes of Health;Universities;uptake;Validation;Work

PROJECT_TITLE: Novel OrganoPET Assay for Precision Therapy of Head and Neck Cancer


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE This application seeks to 1) determine if Smyd1a gain-of-function in mice increases mitochondrial respiration by regulating Opa1 mediated cristae remodeling and supercomplex formation, thereby protecting the myocardium from ischemic injury and 2) determine if the pathogenic SMYD1 variant (N101S) engenders loss-of-function in humans.

PI_NAMEs: FRANKLIN, SARAH  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Adult;Arteries;Binding;Blood flow;Cardiac;Cardiac Myocytes;Cause of Death;Cell Separation;Cells;ChIP-seq;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Congestive Heart Failure;Coronary Arteriosclerosis;Crista ampullaris;Data;Disease;Down-Regulation;effective therapy;Electron Microscopy;Electron Transport;energy efficiency;Epigenetic Process;Event;Exhibits;Fluorometry;gain of function;Gene Expression;Genes;Genetic Transcription;genome-wide;Health;Heart failure;heart metabolism;Histone Deacetylase;Histone-Lysine N-Methyltransferase;Histones;Human;human disease;human tissue;Hypertrophic Cardiomyopathy;in vivo;induced pluripotent stem cell;insight;Ischemia;ischemic injury;Knockout Mice;loss of function;Mediating;Metabolism;Methylation;Methyltransferase;Mitochondria;Molecular;Morphology;mouse model;Mus;Muscle Cells;Mutation;Myocardial dysfunction;myocardial injury;Myocardial Ischemia;Myocardium;novel;OPA1 gene;Orthologous Gene;overexpression;Pathogenicity;Pathologic;Pathway interactions;Patients;Physiology;prevent;Prevention therapy;Production;promoter;protein expression;Protein Isoforms;Protons;Publishing;Regulation;Reperfusion Therapy;Resolution;Respiration;Respiratory Chain;Role;Spirometry;Structure;Tertiary Protein Structure;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;Transcript;Transgenic Mice;Variant;Ventricular

PROJECT_TITLE: The methyltransferase Smyd1 regulates cardiac physiology

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PI_NAMEs: BARNES, LISA L;BEYER, ERIC C (contact)

PROGRAM_OFFICER_NAME: BOUGH, KRISTOPHER J

PROJECT_TERMS: Age;Behavioral;career;career development;Clinical Research;Communication;Communities;Complex;design;Disease;Ethnic Origin;Faculty;Funding;Gender;Goals;health disparity;human disease;improved;Individual;innovation;Institution;Investigation;K-Series Research Career Programs;Lead;member;multidisciplinary;patient population;Program Development;programs;psychologic;Race;Research;Research Personnel;Scholars Program;social;success;Surgeon;Time;tool;Training;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities

PROJECT_TITLE: I. Institutional Career Development Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Prevention

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: Project Narrative Despite being preventable, colorectal cancer is the second most common cause of death from cancer in the US. Almost all colorectal cancer arises from small growths in the colon known as polyps, which are found and painlessly removed during colonoscopy to prevent their possible progression to cancer. In this study, we will clarify the best management for patients with serrated polyps, a type of polyp that leads to as much as 30% of colorectal cancer, providing evidence that will improve colorectal cancer prevention.

PI_NAMEs: AMOS, CHRISTOPHER I.;BUTTERLY, LYNN F (contact);ZAUBER, ANN GRAHAM

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: Accounting;Address;adenoma;Adenomatous Polyps;Age;Benign;Biological;Biometry;Calibration;Cancer Etiology;Cancer Intervention;Cause of Death;Cessation of life;Characteristics;Clinical;Clinical effectiveness;Clinical Management;college;Colon;Colonoscopy;Colorectal;Colorectal Cancer;colorectal cancer prevention;colorectal cancer screening;cost effective;cost effectiveness;Data;data registry;Databases;Detection;Development;Digestive System Disorders;Effectiveness;effectiveness evaluation;Endoscopy;evidence base;Family;follow-up;Future;Goals;Growth;Guidelines;improved;Incidence;indexing;International;Interruption;Investigation;Knowledge;Lesion;Link;Literature;Location;Malignant Neoplasms;medical schools;member;Modeling;models and simulation;mortality;multidisciplinary;Natural History;neoplasm registry;network models;New Hampshire;Outcome;Painless;Pathology;Pathway interactions;Patient risk;patient stratification;Patients;personalized care;Persons;Polyps;population based;Precancerous Polyp;premalignant;prevent;Procedures;Public Health;Recommendation;Recording of previous events;Registries;Research;Risk;Risk Estimate;Risk Factors;risk prediction;risk prediction model;risk stratification;Scientific Advances and Accomplishments;Screening for cancer;screening guidelines;sex;simulation;Site;Surveillance Modeling;surveillance network;surveillance strategy;time interval;tool;United States Preventative Services Task Force;Update

PROJECT_TITLE: Optimizing colorectal cancer prevention: a multi-disciplinary, population-based investigation of serrated polyps using risk prediction and modeling

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative At present, there is no clinically-effective treatment of amyotrophic lateral sclerosis (ALS). This application will test the treatment potency of a novel spinal cord gene delivery in the treatment of ALS. Effect of mutated gene (mSOD1) silencing will be tested in rat G93A model of ALS and the treatment potency defined by the degree of neurological function protection and long-term animal survival.

PI_NAMEs: MARSALA, MARTIN  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: adeno-associated virus 9 delivery;Adult;Aftercare;Alleles;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Animal Model;Animals;Appearance;autosome;Behavior;Biodistribution;Clinical;Clinical Data;clinically relevant;cohort;Data;Development;Devices;Diagnosis;Disease;Dose;effective therapy;end stage disease;Family suidae;Future;Gastrocnemius Muscle;Gene Delivery;Gene Expression;Gene Silencing;Genes;Genome;Goals;Human;Inherited;Injections;Interneurons;Leg;Length;Life Extension;Lumbar spinal cord structure;Mediating;Methods;Modeling;Motor Neurons;mouse model;Mus;Muscle;Mutate;Nervous System Physiology;novel;novel therapeutic intervention;Organ;Organism;Patients;Peripheral;pre-clinical;preclinical development;preservation;Proteins;prototype;Rattus;Research Design;response;Rodent;Safety;Siblings;small hairpin RNA;Spinal;Spinal Cord;Study models;superoxide dismutase 1;Testing;Therapeutic Effect;therapy development;Toxic effect;Transgenic Organisms;treatment duration;treatment effect;vector;vector genome;white matter;Work

PROJECT_TITLE: Spinal Subpial Gene Delivery for Treatment of Amyotrophic Lateral Sclerosis

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Pediatric

ORG_NAME: ASAKE BIOTECHNOLOGY, LLC

PHR: Project Narrative For over a century since its discovery, insulin remains the only effective treatment for type 1 diabetes. By the time patients are diagnosed, the immune system has already targeted and destroyed a vast majority of insulin- producing beta cells needed to regulate the body’s energy needs. Our goal is to develop a single once-a-day drug that could treat type 1 diabetes by 1) protecting beta-cells from the body’s immune system and 2) simultaneously stimulating these cells to produce and release more insulin to make up for what was lost.

PI_NAMEs: NUNEMAKER, CRAIG S;WU, SHIYONG  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: absorption;Age;Alberta province;American;analog;Autoimmune Diseases;Autoimmune Process;Autoimmunity;Beta Cell;Biotechnology;Blood;Blood Glucose;blood glucose regulation;Cell Death;Cell Death Induction;Cells;Cessation of life;Chromatography;Clinical;clinical application;Clinical Trials;Collaborations;cytokine;Cytoprotection;Data;Development;Diabetes Mellitus;diabetes mellitus therapy;Diabetic mouse;Diagnosis;Disease;Disease Progression;drinking water;Drug Kinetics;effective therapy;Energy Metabolism;Excretory function;exhaustion;Food;Glucose;Goals;Grant;Health;Hormones;Human;Hypoglycemia;Immune;Immune system;Immunologic Markers;Implant;improved;improved outcome;In Vitro;Inbred NOD Mice;Incubated;Indiana;Inflammatory;inhibitor;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;insulitis;Interferon Type II;Intramuscular;Intraperitoneal Injections;islet;Islets of Langerhans;Islets of Langerhans Transplantation;Laboratories;Lead;liquid chromatography mass spectrometry;Measurement;Mediating;Metabolism;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Ohio;Oral;Pancreas;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacology;Pharmacology Study;Phase;Population;prevent;Procedures;product development;Proteins;Research Personnel;Residual state;Risk Reduction;Rodent;Route;Series;Signal Transduction;Small Business Technology Transfer Research;small molecule;small molecule therapeutics;Stat5 protein;Structure of beta Cell of islet;subcutaneous;Tail;Techniques;Testing;Therapeutic;Time;TNF gene;Transplantation;Universities;Validation;Veins;Work

PROJECT_TITLE: A dual-acting small molecule for the treatment of type 1 diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(10)B]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Substance Misuse

ORG_CITY: GOLDEN

ORG_NAME: KLEIN BUENDEL, INC.

PHR: Responsible beverage service (RBS) training for alcohol servers is a promising intervention for reducing driving while intoxicated (DWI) by alcohol. Training, certification, and in-service contact improves professionalism and effectiveness of prevention interventions delivered by community members such as alcohol servers. This SBIR Fast-track project will develop and test an in-service professional development component to the WayToServe® online RBS training to improve the effectiveness of RBS training in order to make further gains in reducing problem alcohol behavior in communities.

PI_NAMEs: BULLER, DAVID B (contact);WOODALL, W GILL

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Alcohol abuse;alcohol behavior;alcohol services;Alcoholic Intoxication;Alcohols;Beverages;California;Certification;Cessation of life;Client;commercialization;Communication;Communities;Data;Death Rate;Development;Driving While Intoxicated;Economics;Effectiveness;effectiveness evaluation;Elements;Evaluation;evidence base;Evidence based intervention;Facebook;Flowcharts;Focus Groups;Funding;Gills;Goals;Grant;improved;Incentives;innovation;Intervention;Interview;Intoxication;Legal;Libraries;Licensing;Literature;Marketing;Measurement;Mediator;Medical;member;Names;National Institute on Alcohol Abuse and Alcoholism;National Institute on Minority Health and Health Disparities;New Mexico;Phase;pilot trial;Policies;pressure;prevent;prevention effectiveness;preventive intervention;primary outcome;Principal Investigator;product development;Production;prototype;Public Health;randomized trial;Reaction;recruit;Research;Research Institute;Research Personnel;Resistance;Restaurants;Risk;Sales;Services;Site;skills;Small Business Innovation Research Grant;social;social media;Spanish;Specific qualifier value;success;Surveys;System;Testing;Texas;Text;Time;Training;United States;usability;Vendor;Washington;Work

PROJECT_TITLE: WayToServe Plus: In-service Professional Development Component to Improve Responsible Alcohol Service


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The Training Program in Endocrinology at Massachusetts General Hospital (MGH)’s goal is to train MD, and MD-PhD physician scientists and PhD scientists in clinical and/or laboratory research related to endocrinology, diabetes, metabolism and allied fields. The public health burden of endocrine diseases (such as diabetes and its complications, obesity and osteoporosis) and its associated societal costs are enormous, and therefore there is an urgent need to train and enable the best and brightest individuals considering careers in biomedical investigation to deploy contemporary experimental methods that will generate insights into this set of disorders, elucidate their pathophysiology, and illuminate potential avenues for treatment. With these goals in mind, the MGH Training Program in Endocrinology has produced a large number of endocrine investigators over the years, many of whom have become authentic leaders in science, academia and industry.

PI_NAMEs: MILLER, KAREN K (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Endocrinology;Training Programs

PROJECT_TITLE: Training Program in Endocrinology

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Mannose Receptor (CD206) positive tumor associated macrophages within the metastatic castration resistant prostate cancer (mCRPC) tumor microenvironment correlate with disease progression and play a critical role in suppressing adaptive immune responses and CD8+ T cell exclusion leading to tumor cell growth, invasion, and survival. Our team has demonstrated that CD206+ tumor associated macrophages control immune suppression in tumors, correlate with disease progression and inhibitory targeting of this receptor stimulates anti-tumor immune responses that synergize with chemo- and immune checkpoint therapy. The overall goal of the proposed research is to delineate the mechanistic role of CD206+ tumor associated macrophages in its regulation of suppressing anti-tumor immune responses that lead to prostate tumor growth, metastasis, therapeutic resistance and use these discoveries to develop novel therapeutic strategies.

PI_NAMEs: ZARIF, JELANI CHINELO (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: adaptive immune response;analog;androgen independent prostate cancer;angiogenesis;anti-PD-L1;anti-PD-L1 therapy;anti-PD1 therapy;anti-tumor immune response;cancer cell;Cancer Model;Cancer Patient;CD8-Positive T-Lymphocytes;cell growth;Cells;checkpoint therapy;Clinical Trials;cytotoxic;Diagnosis;Disease;Disease Progression;Endocytosis;Exclusion;genetic signature;Goals;Growth;Host Defense;Human;humanized mouse;Immune;immune cell infiltrate;Immune Evasion;immune resistance;Immune response;Immune Targeting;Immunosuppression;Immunotherapy;In Vitro;in vivo;Infiltration;Inflammatory;innovation;Invaded;Lysosomes;Macrophage;Malignant Bone Neoplasm;Malignant neoplasm of prostate;mannose receptor;Measures;Mediating;Mediator;Medical;men;Metastasis Suppression;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Modeling;Molecular Conformation;mouse model;Mus;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;Nivolumab;NK Cell Activation;novel;novel therapeutic intervention;novel therapeutics;Pathway interactions;patient response;Patient-Focused Outcomes;Patients;Peptides;Phagocytosis;Phagocytosis Induction;Phagosomes;Phenotype;Play;programs;prostate cancer progression;Prostatic Neoplasms;Publishing;receptor;recruit;Refractory;Regulation;Research;Resistance;response;RNA Sequences;Role;Sampling;Surface;synergism;T-Lymphocyte;Therapeutic;therapeutic target;Therapeutic Uses;therapy resistant;Time;treatment response;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;tumorigenesis;Xenograft Model

PROJECT_TITLE: Therapeutic targeting of CD206+ TAMs to enhance adaptive and innate anti-tumor immune responses in metastatic castration-resistant prostate cancer


NIH_SPENDING_CATS: Brain Disorders;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Huntington's disease (HD) is a devastating progressive adult-onset neurodegenerative disease. Currently, there is no treatment or a cure for HD. HD is one of the most common familial neurodegenerative disorders, with 30,000 clinically diagnosed HD patients and another 150,000-200,000 at risk for HD in the US.

PI_NAMEs: GRAY, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Adult;Affect;Astrocytes;autosome;Behavior;Behavioral;behavioral phenotyping;Brain;cell type;Cells;Clinical;clinical diagnosis;Cognitive;Corpus striatum structure;D Cells;Data;design;Development;Disease;Disease Progression;Dopamine D1 Receptor;Dopamine D2 Receptor;effective therapy;Electrophysiology (science);Experimental Designs;experimental study;extracellular;Feedback;Frequencies;Functional disorder;GABA Transporter 1;GAT3 transporter;Genetic study;Glial Fibrillary Acidic Protein;Glutamates;Goals;hippocampal pyramidal neuron;Hippocampus;Huntington Disease;Huntington gene;inhibitory neuron;Interneurons;Knowledge;Length;Modeling;Molecular;motor deficit;Movement;Mus;mutant;Mutate;Nerve Degeneration;nervous system development;Neurodegenerative Disorders;Neuroglia;Neurons;neuropathology;neuroprotection;neurotransmission;optogenetics;overexpression;Parvalbumins;Pathway interactions;Patients;Phenotype;Play;Proteins;Risk;Role;Signal Transduction;Somatostatin;symptom treatment;Synapses;Thalamic structure;Toxic effect;uptake;Viral

PROJECT_TITLE: Exploring the contribution of astrocytes to Huntington disease


ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: NARRATIVE An HIV cure has been an elusive goal and very hard to reach as most therapies targeting only the virus have failed to create a dent on the infected cell which are hiding from a debilitated immune system. Our project will target all the arms of the immune system in order to restore the immune function that can eliminate those HIV- infected cells.

PI_NAMEs: SEKALY, RAFICK PIERRE (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: acute infection;adaptive immune response;Adaptive Immune System;Agonist;Allogenic;anti-PD-1;anti-PD-L1;Anti-Retroviral Agents;Antibodies;Antigens;antiretroviral therapy;arm;Autologous;B-Lymphocytes;Binding;Biological Assay;CCR5 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell killing;Cell Physiology;Cells;Chimerism;Circulation;Clinic;clinical efficacy;cohort;Collaborations;cytokine;cytotoxicity;data integration;Data Set;Dedications;Detection;Disease;Effector Cell;Engraftment;Environment;experimental study;Flow Cytometry;Future;Gene Silencing;Goals;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Heterogeneity;HIV;HIV Infections;host microbiome;Human immunodeficiency virus test;Immune;immune activation;immune activator;immune function;immune reconstitution;Immune response;Immune system;Immune System Diseases;Immune Targeting;immunological intervention;Immunologics;Immunology;immunoregulation;Immunotherapy;Impairment;improved;improved outcome;Individual;Inflammatory;Infusion procedures;Innate Immune Response;Innate Immune System;Interruption;Intervention;Machine Learning;Macrophage;Malignant Neoplasms;Mediating;metabolome;metabolomics;microbial;microbiome;Modality;Modeling;Molecular;Monoclonal Antibodies;Monoclonal Antibody Therapy;monocyte;multidimensional data;multiple omics;Mutation;Nature;network models;neutralizing antibody;novel;novel therapeutics;Participant;PD-1 blockade;PD-1/PD-L1;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Plasma;Positioning Attribute;prevent;programs;Recording of previous events;Refractory;response;Role;Sampling;Signal Transduction;stem;success;synergism;Systems Biology;T cell response;T cell therapy;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic vaccine;Tissues;Translations;Vaccines;Validation;Viral;viral rebound;Viremia;virology;Virus

PROJECT_TITLE: Multi-OMICS identification and validation of mechanisms triggered by Immune interventions aimed at reducing the size of the replication competent Reservoir


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative - Hypertension and vascular stiffening are major risk factors for heart attack, stroke, and kidney failure and contribute to over 350,000 deaths annually in the United States. The goals of this proposal are to identify mechanisms that contribute to the development of hypertension and vascular stiffening, to better understand how these parameters promote atherosclerotic disease, and to generate novel therapeutics for these prevalent conditions.

PI_NAMEs: MACK, CHRISTOPHER P.;TAYLOR, JOAN M (contact)

PROGRAM_OFFICER_NAME: PLAYFORD, MARTIN P

PROJECT_TERMS: Actins;Affect;age related;Animals;Apolipoprotein E;Arterial Fatty Streak;arterial stiffness;arteriole;atherogenesis;atheroprotective;Atherosclerosis;Atherosclerosis Risk in Communities;Biochemical;Biomedical Engineering;blood pressure control;blood pressure reduction;Blood Vessels;calcification;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;causal variant;Cell Physiology;Cells;Cellular biology;Cessation of life;Clinical;Cryoelectron Microscopy;Cues;Cultured Cells;Data;Defect;design;Development;Disease Outcome;drug development;Epidemiology;Event;experience;Extracellular Matrix;Fluorescence Resonance Energy Transfer;Gene Expression Profiling;Gene Expression Regulation;Genes;genetic analysis;Genetic Transcription;genetic variant;Genetic Variation;genome-wide analysis;Genotype;Goals;high throughput screening;Human;Hypertension;Incidence;Inflammatory;interdisciplinary approach;intimal medial thickening;Kidney Failure;Knock-out;Left;Lesion;Libraries;Light;Measures;mechanical signal;Mechanics;member;Methods;Microscopy;Modeling;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Infarction;Necrosis;novel;novel therapeutics;Outcome;overexpression;Pathway interactions;patient population;Patients;Phenotype;Physiological;Play;Post-Translational Protein Processing;pre-clinical;prevent;programs;Resistance;rho;rho GTPase-activating protein;Risk Factors;Role;Rupture;screening;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule;Smooth Muscle;Smooth Muscle Myocytes;Source;Stroke;Tamoxifen;Testing;Therapeutic;tool;transcription factor;United States;Variant;Vascular Diseases;Vascular Smooth Muscle;Work

PROJECT_TITLE: Atheroprotection by smooth muscle selective RhoGAPs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-D(02)M]


PROJECT_TERMS: Adherence;Agreement;Applications Grants;Budgets;Clinical;Clinical Research;clinical research site;Collaborations;collaborative environment;Communication;Communities;community engagement;conflict resolution;Data;data infrastructure;data management;Data Set;data sharing;Data Storage and Retrieval;Databases;Deposition;Disputes;education resources;Ensure;Environment;epigenomics;Ethics;Fostering;Funding;Future;Goals;Grant;HIV;Human;Immunity;immunological intervention;Immunology;Immunotherapy;Infrastructure;innovation;Institution;Institutional Review Boards;Intellectual Property;Laboratories;Lead;Leadership;Link;Machine Learning;material transfer agreement;meetings;member;Metabolic;microbiome;Modeling;multiple omics;organizational structure;Postdoctoral Fellow;Productivity;Program Evaluation;Program Research Project Grants;programs;Progress Reports;Property Rights;Recommendation;Regulatory Pathway;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Role;Sampling;Students;synergism;timeline;tool;transcriptomics;Validation;Viral;web site;Work

PROJECT_TITLE: MOIR - Administrative Core


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE A major goal in biology is to understand how the human genome encodes cell type specific gene expression programs that are required for the function of diverse cell types. We have created a new epigenetic editing approach that we have named CRISPRoff which enables us to map functional gene regulatory elements. We are now proposing to extend this approach to map gene regulatory elements across an entire human chromosome and measure the outcomes at single cell resolution which is a key step towards understanding how tissue-specific gene expression is controlled.

PI_NAMEs: GOODARZI, HANI  (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Address;Biology;biomedical scientist;Brain;Cell division;cell type;Cells;Chimeric Proteins;Chromosome Mapping;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Code;combinatorial;Communities;Correlative Study;CpG Islands;CRISPR screen;Deposition;Development;Disease;DNA;DNA Methylation;DNA Methylation Regulation;DNA Sequence;Elements;Enhancers;epigenetic memory;Epigenetic Process;epigenome editing;experimental study;functional genomics;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene repression;Gene Silencing;Genes;Genetic Enhancer Element;genetic regulatory protein;Genetic Transcription;Genome;Genomic approach;Genomics;Genotype;Goals;histone modification;Histones;Human;Human Biology;Human Chromosomes;human disease;Human Genome;Human Genome Project;human pluripotent stem cell;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Maps;Measures;Memory;Methods;Methylation;Modeling;Names;nerve stem cell;Neurons;Nucleic Acid Regulatory Sequences;Outcome Measure;Phenotype;Pluripotent Stem Cells;programs;promoter;Proteins;Regulation;Regulatory Element;Research;Resolution;Resources;Sequence-Specific DNA Binding Protein;Specific qualifier value;stem cell differentiation;stem cells;Technology;Testing;Tissue-Specific Gene Expression;tool;transcription factor;transcriptome;Untranslated RNA;Writing

PROJECT_TITLE: Editing CG and non-CG DNA methylation to identify genomic elements that regulate gene expression

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Data Science;Genetics;HIV/AIDS;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SHARMA, ASHISH ARUNKUMAR (contact)

PROJECT_TERMS: Acceleration;Adaptive Immune System;anti-PD1 antibodies;antibody immunotherapy;Binding;Bioinformatics;Biological Assay;Biological Models;Biological Process;Biometry;CCR5 gene;CD4 Positive T Lymphocytes;Cells;Clinical Data;Data;data management;Data Set;Diet;DNA;Environment;Environmental Risk Factor;Epigenetic Process;epigenome;experimental study;FAIR principles;Future;Generations;Genes;Heterogeneity;HIV;HIV-1;Human;immune function;immunological intervention;immunoregulation;Individual;Infection;Infusion procedures;Innate Immune System;insight;large scale data;Machine Learning;Maintenance;Maps;metabolome;Microbe;microbiome;Mission;Modeling;multiple omics;National Institute of Allergy and Infectious Disease;neutralizing antibody;novel;Outcome;power analysis;Process;programs;Proteins;public repository;Publications;Recurrence;Regulation;Reproducibility;Research;Resources;Sampling;Services;Therapeutic;Therapeutic Intervention;transcriptome;Validation;Viral Load result;viral rebound;Virus Replication;Visualization

PROJECT_TITLE: MOIR - Machine Learning and Modeling Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: The high prevalence of opioid use among justice-involved adults has led to growing interest and acceptance in using jails to identify and treat those with opioid use disorder (OUD). But our understanding of optimal delivery approaches and their effects in these settings is incomplete. This study addresses this important public health question by experimentally testing the potential benefits of commencing pharmacotherapy at admission (rather than at release) with regard to key psychological and behavioral outcomes in the jail as well as in the community re-entry phase.

PI_NAMEs: FARABEE, DAVID J (contact);STOPKA, THOMAS J

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Address;Admission activity;Adult;Agreement;Behavioral;behavioral outcome;Birds;Buprenorphine;Caring;Collaborations;Communities;community reentry;community setting;Consent;County;craving;Criminal Justice;Data;Dose;Drug Metabolic Detoxication;Eligibility Determination;Enrollment;Evaluation;experience;experimental group;FDA approved;follow-up;Formularies;Formulation;Goals;Health;Health Personnel;Health Services;High Prevalence;illicit opioid;Imprisonment;Individual;Injections;interest;Jail;Justice;Lead;Letters;Maintenance;Massachusetts;Measures;Medicaid;Medical;medication for opioid use disorder;New York;opiate tolerance;Opioid;opioid mortality;opioid use;opioid use disorder;Oral Administration;Outcome;Overdose;Participant;patient oriented;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Pilot Projects;Population;Prevalence;Prisons;Problem behavior;Protocols documentation;psychologic;psychological distress;psychological outcomes;Public Health;Randomized;Randomized, Controlled Trials;recidivism;Recording of previous events;Records;Recovery;Relapse;relapse risk;Research;Research Infrastructure;Research Personnel;Risk Reduction;Sampling;Site;Subcutaneous Injections;Suboxone;System;Testing;text searching;Time;Toxicology;trafficking;treatment as usual;Universities;Urine;virtual;willingness;Withdrawal;Work

PROJECT_TITLE: Assessing Optimal XR-Buprenorphine Initiation Points in Jail

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Arctic;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PHR: NARRATIVE This is a five-year grant application for a prospective observational clinical study to assess the prognosis of periodontal disease and dental caries management of seniors, including Alaska Native seniors. This is relevant to public health and clinical research because rigorous assessment of periodontal disease and caries management prognosis will lead to a dental workforce better prepared to treat seniors in general, and American Indian and Alaska Native seniors, in particular; and thus help the aging population enjoy better oral health. The proposed research addresses NIDCR strategic plan's goals to apply rigorous, multidisciplinary research approaches to overcome disparities and inequalities; support best science; enable precise and personalized health care through research; and ensure a strong research workforce dedicated to improving dental, oral and craniofacial health.

PI_NAMEs: CUNHA-CRUZ, JOANA  (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: Address;Affect;Aging;aging population;Alaska;Alaska Native;Alaska Native population;American Indians;Applications Grants;burden of illness;Caring;Characteristics;Clinical;clinical decision-making;Clinical Research;Clinical Trials;craniofacial;Data;Dedications;Dental;Dental Care;Dental caries;Dental General Practice;Dental Records;Diagnosis;disease diagnosis;Disease Management;disorder control;Disparity;economic disparity;Elderly;electronic data;Enrollment;Ensure;Environment;ethnic difference;ethnic disparity;Ethnic Origin;Ethnic Population;experience;follow-up;geographic disparity;Geographic Locations;Geriatric Dentistry;Goals;Health;health care service organization;health disparity;health inequalities;health related quality of life;Healthcare;improved;Individual;Inequality;innovation;Interdisciplinary Study;Knowledge;Lesion;Life;Longevity;Managed Care;Mouth Diseases;National Institute of Dental and Craniofacial Research;Observational Study;older adult;Oral;Oral cavity;Oral Examination;Oral health;Outcome;Patient Outcomes Assessments;Patients;Periodontal Diseases;Periodontitis;personalized health care;Population;Population Group;practice setting;primary outcome;Prognosis;prognostic;Prognostic Factor;prospective;Prospective cohort;Prospective Studies;Protocols documentation;Provider;Public Health;Questionnaires;Race;racial difference;racial disparity;radiological imaging;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Rural;Science;secondary outcome;Strategic Planning;success;Tooth Loss;Tooth structure;Treatment Efficacy;tribal healthcare;Uncertainty;United States;Visual

PROJECT_TITLE: Seniors Oral Health in Southeast Alaska

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


PROJECT_TERMS: adaptive immune response;adaptive immunity;Agonist;antiretroviral therapy;B-Lymphocytes;Binding;Biological Assay;CD4 Positive T Lymphocytes;Cells;Clinical;Clinical Trials;Competence;Cytotoxic T-Lymphocytes;Data;Effector Cell;Epigenetic Process;Fc Receptor;gut dysbiosis;HIV;HIV Infections;Immune;immune reconstitution;Immune response;immunological intervention;Immunologics;immunoregulation;Infection;Inflammatory;Infusion procedures;innate immune mechanisms;Innate Immune Response;integration site;Intervention;Intervention Trial;Malignant Neoplasms;Measures;metabolome;microbiome;multiple omics;Natural Immunity;neutralizing antibody;Proviruses;Refractory;response;Sampling;synergism;T-Lymphocyte;T-Lymphocyte and Natural Killer Cell;Testing;Therapeutic;Time;Translations;Validation;Viral;Viral Load result;Viral Proteins;viral rebound

PROJECT_TITLE: I2 Control= Modulating Innate Immunity to Achieve Control of HIV


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Allergic diseases constitute a major health burden and have a definite genetic component; however, the genes regulating allergy are largely unexplored. Recently, we conducted a classic genetic screen of allergy, which yielded several novel phenotypes of IgE production including benadryl, which rendered mice resistant to anaphylaxis. This proposal seeks to characterize how a mannose producing enzyme regulates IgE production, glycosylation, and function in allergic disease models.

PI_NAMEs: SORELLE, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Affect;Alleles;Allergens;Allergic;Allergic Disease;Allergic Reaction;Anaphylaxis;Animal Model;Antibodies;Antigens;Asthma;B-Lymphocytes;Binding;Biochemical;Bypass;career;Cell Count;Cell Line;cell type;Cells;Cellular Assay;Cellular Immunology;Clinical;clinically relevant;Collection;conditional knockout;CRISPR/Cas technology;crosslink;Cytoplasmic Granules;Defect;Development;Diphenhydramine;Disease;disease model;Economic Burden;Eczema;Enzymes;Ethylnitrosourea;Food Hypersensitivity;Fructose;Functional disorder;Future;gene discovery;Genes;Genetic;Genetic Predisposition to Disease;Genetic Screening;genetic testing;Glycolysis;glycosylation;Goals;Grant;Health;Health system;Hereditary Disease;Histamine Release;Human;Humor;Hypersensitivity;IgE;Immune;Immune system;Immunity;Impairment;In Vitro;inorganic phosphate;insight;Institution;interest;Investigation;Isomerase;K-Series Research Career Programs;Knock-in;Knockout Mice;Learning;Life;Link;Lysosomes;Mannose;mannose 6 phosphate;Maps;Mass Spectrum Analysis;mast cell;Measures;Mediating;Medicine;meetings;Meiosis;Mentors;Metabolic;Metabolism;Methods;Modeling;Molecular Biology;mouse model;Mouse Strains;Mus;Mutagens;Mutate;Mutation;Names;new therapeutic target;novel;novel therapeutic intervention;Papain;Paper;passive sensitization;Pathway interactions;Peptide Hydrolases;Peritoneal;Phenotype;Physicians;Physiological;Population;Process;Production;Proteins;Proteomics;receptor;Regulation;Research Personnel;Resistance;Resources;Role;Scientist;Secondary to;Severities;Signal Transduction;skills;Structure;sugar;Supplementation;Surface;T-Lymphocyte;Temperature;Testing;therapeutic target;trafficking;Translating;Writing

PROJECT_TITLE: Genetic Regulation of IgE Glycosylation

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Sexual minorities are at heightened risk of alcohol misuse; however, existing research is largely based on a static and unidimensional construct of sexual orientation rather than a fluid and multidimensional construct of sexual orientation. This longitudinal population-based study will examine the fluidity and multidimensionality of sexual orientation, improve longitudinal estimates of alcohol misuse and its negative health consequences, and identify modifiable risk and protective factors in multiple domains (individual-, social- and policy-level). This study will provide new information to improve assessment, prevention, screening, and intervention efforts targeted towards reducing alcohol-related consequences among sexual minorities.

PI_NAMEs: EVANS-POLCE, REBECCA J. (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Address;Adolescent;Adult;Age;alcohol measurement;alcohol misuse;alcohol related consequences;alcohol risk;alcohol use disorder;Alcohols;Behavior;Cannabis;Complement;cost;COVID-19;Criminal Justice;Data;Dimensions;Discrimination;Distal;Engineering;ethnic identity;fluidity;Gender Identity;gender minority group;gender minority health disparity;Goals;Health;health data;Healthcare;Heterogeneity;Heterosexuals;improved;Individual;interest;Intervention;Laws;Lesbian Gay Bisexual;Liquid substance;longitudinal design;Longitudinal Studies;Measures;Medicine;Modeling;modifiable risk;Movement;neglect;Outcome;Patient Self-Report;Pharmaceutical Preparations;physical conditioning;Policies;polysubstance use;Population Assessment of Tobacco and Health;population based;Population Study;Prevention;Productivity;protective factors;Public Policy;public policy on alcohol;racial identity;Reporting;Research;Research Design;response;Risk;Risk Factors;Sampling;screening;secondary analysis;Severities;Sex Orientation;Sexual and Gender Minorities;sexual identity;sexual minority;sexual minority group;sexual minority health;sexual minority women;Shapes;social;Social Concepts;Social Interaction;stressor;Subgroup;Substance Use Disorder;Symptoms;Time;Tobacco;United States National Academy of Sciences;Variant;Work;Youth

PROJECT_TITLE: Sexual Fluidity and Longitudinal Changes in Alcohol Misuse and Associated Health Consequences

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adaptive immune response;adaptive immunity;Address;Affect;Aftercare;Animals;anti-PD-1;anti-PD1 antibodies;Anti-viral Response;antiretroviral therapy;Antitumor Response;Binding;Bioinformatics;Biological Assay;Cancer Patient;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell surface;Cells;checkpoint therapy;chemokine;clinical trial protocol;clinically significant;cohort;commensal bacteria;Complex;CTLA4 gene;cytokine;Data;Data Analyses;data integration;Death Rate;Disease Progression;DNA;effector T cell;exhaust;exhaustion;Frequencies;Genetic Transcription;Heterogeneity;HIV;Homeostasis;Immune;immune checkpoint;immune checkpoint blockade;immune function;immune reconstitution;Immune response;Immune system;Immune System Diseases;Immunity;immunological intervention;Immunologics;Immunology;Immunology procedure;immunoregulation;Impairment;improved;in vivo;Individual;Inflammation Mediators;Inflammatory;inflammatory milieu;Inflammatory Response;innate immune mechanisms;Innate Immune Response;integration site;Interruption;Intervention;Kaposi Sarcoma;Knowledge;Lead;Maintenance;Malignant neoplasm of cervix uteri;Malignant Neoplasms;metabolome;microbiome;Monoclonal Antibodies;multiple omics;Natural Immunity;Non-Hodgkin's Lymphoma;Outcome;Participant;pathogen;Patients;PD-1 blockade;PD-1/PD-L1;PD-L1 blockade;Persons;Plasma;post intervention;Predisposition;programmed cell death ligand 1;programmed cell death protein 1;programs;Proteins;recruit;Rejuvenation;Research;restoration;RNA;Role;Shapes;Signal Transduction;SIV;Subgroup;System;T cell response;T-Lymphocyte;Testing;Therapeutic;treatment response;tumor;tumor microenvironment;Tumor Promotion;Validation;Viral;viral DNA;Viral reservoir;viral RNA;Viremia;Work

PROJECT_TITLE: MultiOMICS mechanistic identification of predictors of HIV DNA decay, restoration of immune homeostasis and HIV specific immunity in PWH with cancer receiving Immune check point therapy


ORG_CITY: CLEVELAND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: The overall goal of CasePREP is to develop recent baccalaureate science graduates from diverse backgrounds under-represented in biomedical sciences so that they have the necessary knowledge and skills to pursue PhD or MD-PhD degrees in these fields. CasePREP, has been notably successful in matriculating 54 Scholars into top-tier PhD or MD/PhD programs across the nation. The current proposal seeks to continue this program by funding eight Case PREP Scholars each year for an additional 5 years.!

PI_NAMEs: CRAWFORD, DANA C (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Active Learning;Admission activity;American;apprenticeship;Attitude;Award;Biomedical Research;career;cohort;Communication;Credentialing;Data Analyses;Degree program;design;Development;diversity and inclusion;Doctor of Philosophy;Doctor's Degree;doctoral student;Education;education research;Educational workshop;Enrollment;Environment;experience;Experimental Designs;Exposure to;Faculty;faculty mentor;Fostering;Foundational Skills;Funding;Future;Goals;graduate school;Grant;GRE Preparation;Healthcare;Immersion;improved;Individual;Inosine Diphosphate;Institution;International;Interview;Knowledge;Laboratories;Laboratory Research;Learning;matriculation;medical schools;Mentors;Minority;next generation;Oral;Outcome;Outcome Assessment;peer;peer coaching;Population;Postbaccalaureate;programs;Readiness;Recording of previous events;Research;Research Personnel;Research Training;Scholars Program;Science;Scientist;Series;Shapes;skill acquisition;skills;Socialization;Societies;Students;success;Support System;System;Talents;Training;Training Programs;Underrepresented Minority;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: CWRU Postbaccalaureate Research Education Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Infectious Diseases;Natural Products

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: Project Narrative Antibiotic-resistant infections are increasingly encountered by physicians and their patients. The chemical syntheses of antibacterial natural products and analogues is a proven strategy for furnishing clinically relevant therapeutics, but the construction of such complex, functional-group laden molecules often necessitates creative methodological advances. The primary objective of this proposal is to develop new tethered aza-Wacker synthetic technology for the application in the syntheses of the potent antibiotics Bactobolins A-B and Acybolin A.

PI_NAMEs: SATHYAMOORTHI, SHYAM  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Tethered aza-Wacker Technology for Complex Antibiotic Assembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Immunotherapy;Infectious Diseases;Microbiome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: MARTINEZ-PICADO, JAVIER  (contact)

PROJECT_TERMS: Adoptive Transfer;Allogenic;Anti-Retroviral Agents;Anti-viral Response;antiretroviral therapy;Autologous;Automobile Driving;Berlin;Bile Acids;Binding;Biological Assay;Case Study;CCR5 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Differentiation process;Cell Physiology;Cell Therapy;Cells;Chimerism;Cities;Citric Acid Cycle;Clinical;Clinical Trials;cohort;Competence;Complex;cytokine;Cytotoxic T-Lymphocytes;Data;data integration;density;Disease remission;DNA;DNA Sequence Alteration;Donor person;Effector Cell;effector T cell;Engraftment;Environment;Epigenetic Process;exhaustion;expectation;Experimental Designs;Extravasation;Fatty Acids;Flow Cytometry;Frequencies;Genetic Transcription;gut dysbiosis;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Heterogeneity;high risk;HIV;HIV resistance;HIV-1;Homeostasis;Immune;immune activation;immune reconstitution;Immune response;Immunity;immunological intervention;Immunologics;Immunology;Immunotherapy;in vitro Assay;Individual;Infection;Inflammatory;Infusion procedures;Innate Immune Response;Integration Host Factors;integration site;Interruption;Intervention;Kinetics;latent HIV reservoir;Life;lipidomics;London;Medical;Memory;Metabolic;metabolome;metabolomics;Metadata;microbial;microbial host;microbiome;microbiota;Monitor;multiple omics;Myeloid Cells;New York;novel;Outcome;Participant;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Plasma;Procedures;Proviruses;reconstitution;Refractory;Regimen;Rejuvenation;Reporting;Resistance;response;Role;Safety;Shapes;stem;Stem cell transplant;stem cells;study population;success;T cell therapy;T-Cell Development;T-Lymphocyte;Technology;Testing;Translations;Validation;Viral;Viral Load result;viral rebound;Viral reservoir;Viremia;virology;Virus Replication;Volatile Fatty Acids

PROJECT_TITLE: MultiOMICS to uncover immune and virological mechanisms that drive HIV DNA decay, restore immune homeostasis, and promote HIV specific immunity in PWH receiving cell therapies.


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: HIV infection results in rapid disease progression and death in infants more than any other age group. This proposal will assess the role of sustained type-1 interferon responses on the ability to mount humoral immune responses as well as the relationship between rapid disease progression and the latent viral reservoir. Our long-term goal is to identify therapeutic targets in HIV+ infants that exhibit rapid or typical disease trajectories to optimize antiretroviral drug administration and improve health outcomes.

PI_NAMEs: SODORA, DONALD L (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: 2 year old;Acquired Immunodeficiency Syndrome;Acute;acute infection;Adult;age group;antagonist;Anti-Retroviral Agents;Antibodies;Antibody Response;Antibody titer measurement;antiretroviral therapy;B-Lymphocytes;Biological Assay;Biological Models;Blood;Breast Feeding;CD4 Positive T Lymphocytes;Cells;Child;Childhood;Collaborations;Data;Disease;Disease Outcome;Disease Progression;DNA;effectiveness evaluation;Event;Exclusive Breastfeeding;Exhibits;experience;experimental study;Frequencies;Functional disorder;Future;Genes;Goals;Health;Helper-Inducer T-Lymphocyte;HIV;HIV Infections;Human Milk;human old age (65+);hypogammaglobulinemia;Immune;immune function;Immune response;Immune System Diseases;Immunoglobulin G;Immunoglobulin M;Immunologic Factors;Immunologics;Immunotherapy;Impairment;improved;Infant;infant infection;Infant Mortality;Infection;insight;Interferon Receptor;Interferons;Laboratories;Laboratory Study;Lead;low income country;lymph nodes;Lymphoid Tissue;Macaca;Macaca mulatta;Maintenance;Measures;Memory B-Lymphocyte;Modeling;Morbidity - disease rate;mortality;Mother-to-child HIV transmission;Oral;Outcome;Pathologic;pediatric human immunodeficiency virus infection;peripheral blood;Pharmaceutical Preparations;Phenotype;Plasma;Predisposition;Productivity;protein expression;Recommendation;Recovery;Research;Research Personnel;response;RNA;Role;Route;Severity of illness;Signal Transduction;Site;SIV;Spleen;Structure of germinal center of lymph node;T-Cell Depletion;therapeutic target;Tissues;transmission process;Vaccination;Viral Load result;Viral reservoir;Viremia;Virus Latency;Virus Replication;Vulnerable Populations;Water

PROJECT_TITLE: Rapid disease progression and viral reservoir formation in SIV-infected infant macaques

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PHR: Project Narrative Our preliminary data suggest that a small family of druggable molecules (NR4A1-3) can regulate multiple layers of T cell tolerance to the body’s own tissues. In this proposal, we aim to define the physiological significance and mechanisms of these effects. This will pave the way for developing new therapeutics to target the NR4A family in order to suppress inappropriate autoimmune responses and maintain tolerance to transplanted organs. Alternatively, NR4A function could be manipulated to enhance immune responses in the context of tumors and vaccination.

PI_NAMEs: ZIKHERMAN, JULIE  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Acute;Agonist;anergy;antagonist;Anti-Inflammatory Agents;antigen-specific T cells;Antigens;Antinuclear Antibodies;Autoantigens;Autoimmune Responses;autoreactive T cell;B-Cell Activation;B-Lymphocytes;Bacterial Artificial Chromosomes;BCL2L11 gene;Biology;Bone Marrow;Bypass;CD4 Positive T Lymphocytes;Cell Compartmentation;Cell Death Induction;Cells;Chimera organism;chromatin remodeling;Chronic;Clonal Deletion;Coupled;cytokine;Data;defined contribution;Disease;DNA Binding Domain;Epigenetic Process;exhaust;Exhibits;expectation;Family;Family member;FOXP3 gene;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic approach;Genetic Transcription;Genomic approach;Germ Lines;Goals;Homeostasis;Immune;Immune response;Immunosuppression;Impairment;Inflammatory;innovation;Interleukin-2;Knowledge;Ligands;Lymphocyte;Mediating;member;Molecular;Mus;non-genomic;novel;novel therapeutics;NR4A1 gene;NR4A2 gene;Nuclear Family;Nuclear Hormone Receptors;Nuclear Receptors;Organ Transplantation;Orphan;Pattern;Peripheral;Phenocopy;Phenotype;Physiological;Play;preservation;Production;programs;Proliferating;Publishing;Radiation Chimera;Regulation;Regulatory T-Lymphocyte;Reporter;Repression;response;restraint;Role;Signal Transduction;single cell genomics;small molecule;T cell anergy;T cell response;T-Cell Development;T-Lymphocyte;Testing;Therapeutic;thymocyte;Thymus Gland;Tissues;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;tumor;Vaccination

PROJECT_TITLE: Regulation of CD4 T cell tolerance by the NR4A family of nuclear receptors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-C(02)]


NIH_SPENDING_CATS: Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Rare Diseases

PHR: PROJECT NARRATIVE  Successful anti-metastasis treatment is rooted deep in our mechanistic understanding the interaction between disseminated tumor cell and metastatic microenvironment. Using transgenic mouse models, single cell genetics and multiplexed deep-tissue imaging, we aim to trace and analyze dynamics of cells contributing to neuroinflammation and cancer brain metastasis. The conceptual advances validated from this study will serve as a blueprint for future adjuvant therapies targeting brain metastatic microenvironment, providing more effective anti-metastasis treatments.

PI_NAMEs: ZHANG, SIYUAN  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Adjuvant Therapy;Astrocytes;Basic Science;Behavior;Brain;brain cell;Brain Neoplasms;brain shape;Cancer Biology;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;clinical practice;Computational Biology;Development;Encephalitis;Endothelial Cells;Evolution;Future;Genetic;Genetic Variation;Genomic approach;Heterogeneity;Image Analysis;imaging approach;Immune;Immune system;Immunosuppression;improved;In Situ;in vivo;Incidence;Infiltration;inhibitor;innovation;insight;interdisciplinary approach;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Measures;Mediating;Metastatic malignant neoplasm to brain;migration;Molecular;mortality;mouse model;multidisciplinary;Neoplasm Metastasis;neoplastic cell;nerve stem cell;neural;neuroinflammation;Neurons;Neurosciences;novel;Organ;Outcome;Patients;Phenotype;pre-clinical;pre-clinical research;Preclinical Testing;prevent;Primary Neoplasm;Process;rational design;Regulation;Research;Resolution;response;Role;Signal Transduction;single cell analysis;single cell sequencing;single-cell RNA sequencing;Spatial Distribution;spatial relationship;spatiotemporal;targeted treatment;Therapeutic;Three-Dimensional Image;three-dimensional visualization;Tissue imaging;Tissue Sample;transcriptome;transcriptomics;Transforming Growth Factor beta;Transgenic Mice;Tropism;tumor;tumor progression;validation studies;Visualization

PROJECT_TITLE: Neural Niche in Promoting Brain Metastatic Tumor Progression

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Genetics

ORG_DEPT: GENETICS

PHR: Project Narrative The SWI/SNF complex is a critical regulator of gene expression and is frequently mutated in a wide range of human diseases. This complex is combinatorially assembled from approximately 30 genes, yet we don’t understand how these assemblies are regulated or what the consequences are of having different compositions. The goal of this project is to define new mechanisms that regulate chromatin remodeler composition and function.

PI_NAMEs: RAAB, JESSE R. (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Biochemical;Chromatin;Chromatin Remodeling Factor;combinatorial;Complex;Development;Disease;functional outcomes;Gene Expression;Gene Expression Regulation;Genes;Goals;Human;human disease;insight;Malignant Neoplasms;Mediating;Molecular;mutant;Mutate;novel strategies;novel therapeutics;Outcome;Play;Positioning Attribute;Post-Translational Protein Processing;Regulator Genes;RNA;Role;SWI/SNF Family Complex;tumor;Variant

PROJECT_TITLE: Mechanisms of SWI/SNF complex assembly and function

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: AG

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE – OVERALL  Over the last 20 years, Arizona researchers established NIA's first statewide Alzheimer's Disease Center and the nation's most extensive statewide collaboration in AD research. They have made pioneering contributions to the unusually early detection, tracking and study of AD and the accelerated evaluation of prevention therapies. The Arizona AD Research Center (ADRC) will capitalize on the Center's leadership, statewide collaborative model, major organizational commitments, and extensively shared scientific resources to (a) support a wide range of important studies, (b) provide a springboard for new programs and partnerships, (c)) advance research, treatment development and care in Arizona's under-represented Hispanic/Latino and Native American communities, (d) help develop the next generation of AD and related dementia (ADRD) researchers, including those from diverse backgrounds, (e) continue to make the fight against AD a top priority, (f) build upon our leadership roles in the unusually early detection, tracking and study of AD, and (g) help them find effective AD prevention therapies as soon as possible. The ADRC's resources, strategic plan, and related programs and prevention trials are specifically intended to set the stage for promising blood tests to transform AD/ADRD research, treatment development, and care, include persons from diverse backgrounds, find an effective prevention therapy by 2025, and fulfill National Alzheimer's Project Act (NAPA) goals.

PI_NAMEs: LANGBAUM, JESSICA BROOKE (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Area;Arizona;Autopsy;Biological;Biological Markers;Blood specimen;Blood Tests;blood-based biomarker;Brain;Brain imaging;brain tissue;Caring;Catchment Area;Cerebrospinal Fluid;Clinical;clinical care;clinical research site;Cognitive;Collaborations;Contracts;Data;data management;data resource;Development;Diagnosis;Diagnostic;Disease;Early Diagnosis;Education;Education and Outreach;education research;Evaluation;Family;Family Caregiver;fighting;forging;Funding;Genetic;Goals;Grant;Hispanic;Informatics;innovation;Institution;Interdisciplinary Study;Investments;Latino;Leadership;Life;Magnetic Resonance Imaging;Measurement;Mentorship;metropolitan;Minority;Modeling;National Institute on Aging;Native American community;Native Americans;neuropathology;next generation;outreach;outreach program;Participant;Patients;Persons;Philanthropic Fund;Positron-Emission Tomography;preclinical study;prevention evaluation;Prevention Research;Prevention therapy;Prevention trial;Process;Productivity;programs;Publications;recruit;Research;Research Personnel;Resource Sharing;Resources;Risk;Role;Sampling;Secure;statistics;Strategic Planning;tau Proteins;Testing;therapy development;tool;Training;training opportunity;Underrepresented Populations;Update;Validation;Vision

PROJECT_TITLE: Arizona Alzheimer's Disease Research Center


ADMINISTERING_IC: AT

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Assistive Technology;Autoimmune Disease;Behavioral and Social Science;Bioengineering;Clinical Research;Complementary and Integrative Health;Diabetes;Networking and Information Technology R&D (NITRD);Pediatric;Prevention

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

PI_NAMEs: VOIDA, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: HORGUSLUOGLU, EMRIN U

PROJECT_TERMS: Address;Adherence;Adolescent;Adolescent and Young Adult;Adoption;Adverse event;Affect;aged;Algorithms;analog;Artificial Pancreas;Attention;autoimmune pathogenesis;Awareness;Behavior;Behavior Therapy;Behavioral;Behavioral Model;Blood Glucose;blood glucose regulation;Bolus Infusion;Cells;Chronic;Clinical;Cognitive;cognitive load;Collaborations;computer human interaction;Consumption;Continuous Glucose Monitor;correctional system;cyber physical;Data;decision making algorithm;design;Development;Devices;Diabetes Mellitus;diabetes self-management;Educational Intervention;Educational workshop;Equilibrium;Ethics;euglycemia;Evaluation;Exhibits;Frequencies;Friction;Future;glucose monitor;glycemic control;Goals;handheld mobile device;Health;Heart Rate;Hybrids;improved;Individual;Infusion procedures;Instruction;Insulin;Insulin-Dependent Diabetes Mellitus;Intervention;Interview;Learning;life span;Link;Lived experience;Maintenance;mathematical model;Measures;Medical Device;Medical Technology;mental state;Modeling;Moods;mortality risk;multi-component intervention;multidisciplinary;next generation;novel;Outcome;Pancreas;Participant;Patients;person centered;Persons;Physical activity;Physiological;Population;pre-clinical;Privacy;Privatization;programs;Psyche structure;psychologic;Psychology;psychosocial;Public Health;Public Health Informatics;Qualitative Research;Questionnaires;Research;research study;response;Risk Reduction;Role;Self Management;Self-Help Devices;sensor technology;Series;Statistical Models;Stress;Structure;Surveys;System;Techniques;Technology;technology development;Testing;Time;Trust;wearable sensor technology;Work;Workload

PROJECT_TITLE: SCH: Striking a Balance: Trust and Privacy in Using Adolescents' Data for Diabetes Self-Management

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: NARRATIVE: OVERALL The University of Kentucky Alzheimer’s Disease Research Center (UK-ADRC) facilitates and supports basic/translational and clinical research efforts to identify the early manifestations of disease and the pathogenic mechanisms underlying the transitions from normal aging to the development of cognitive impairment, with a special focus on mixed pathology and co-morbidities that influence risk and outcomes in late-life multi-etiology dementia. We are also dedicated to training the next generation of researchers, and to growing our educational programs and community partnerships to promote awareness of AD and related disorders and the importance of research and research participation.

PI_NAMEs: VAN ELDIK, LINDA J (contact)

PROJECT_TERMS: Address;African American;Aging;aging brain;Alzheimer's Disease;Area;Autopsy;Awareness;Basic Science;beneficiary;Biological;Biological Markers;Biometry;Brain;Caring;central database;Cessation of life;Clinical;clinical practice;Clinical Research;Clinical Trials;Cognitive;Cognitive aging;cohort;Collaborations;collaborative environment;Collection;Communities;Community Health Education;Community Outreach;community partners;community partnership;comorbidity;data management;Dedications;Dementia;Development;Disease;driving force;Early identification;Education;education research;Elderly;Ensure;Environment;Etiology;experience;Family;Goals;Health Personnel;Heterogeneity;Impaired cognition;Impairment;Individual;Infrastructure;innovation;Institution;Kentucky;Knowledge;late life;Longitudinal cohort;Mission;Neurodegenerative Disorders;neuropathology;next generation;normal aging;novel therapeutics;Outcome;outreach;Pathogenicity;Pathology;pre-clinical;programs;Recommendation;recruit;Research;Research Personnel;Research Project Grants;research study;Resources;Risk;Scholars Program;statistics;success;Training;Translating;Translational Research;United States;United States National Institutes of Health;Universities;volunteer

PROJECT_TITLE: University of Kentucky Alzheimer's Disease Research Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

PHR: Per RFA-AG-21-019: Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.

PROJECT_TERMS: accurate diagnostics;Administrator;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease related dementia;Autopsy;beneficiary;Biological;Brain;Brain Pathology;Capital;Caregivers;Cessation of life;Clinical;Cognitive;Cognitive aging;cohort;Collaborations;Communication;Communities;comorbidity;Decision Making;Dementia;Development;diagnostic strategy;disease heterogeneity;Doctor of Philosophy;effective therapy;Elderly;Ensure;Environment;Etiology;Fostering;Foundations;Goals;Heterogeneity;Human Resources;Human Volunteers;Impaired cognition;Individual;Infrastructure;innovation;Kentucky;Knowledge;late life;Leadership;meetings;Modality;Monitor;multidisciplinary;neuropathology;Neurosciences;novel therapeutics;Occupational activity of managing finances;Pathogenicity;Pathology;Patients;pre-clinical;prevent;Prevention;programs;Research;Research Activity;Research Personnel;Resources;Risk;Risk Factors;Science;Strategic Planning;Structure;success;System;Tissues;Training and Education;training opportunity;Translational Research;treatment strategy;United States;Universities;volunteer

PROJECT_TITLE: Core A:  University of Kentucky Alzheimer's Disease Core Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: JICHA, GREGORY A (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease related dementia;Area;Automobile Driving;Autopsy;Biological Markers;Brain;Clinic;Clinical;clinical phenotype;Clinical Trials;Cognitive;cohort;Collaborations;Communities;Correlative Study;Dementia;design;Development;Diagnosis;Disease;driving force;Education;Elderly;Enrollment;Environment;Etiology;Family;Fostering;Frontotemporal Lobar Degenerations;Funding;Genetic;Goals;Heterogeneity;high risk;Image;Individual;Industry;Infrastructure;innovation;Intervention;Kentucky;late life;Link;Liquid substance;Longitudinal cohort;Measures;Minority;minority engagement;Minority Groups;Mission;multidisciplinary;normal aging;novel;novel therapeutic intervention;parity;Participant;Pathologic;Pharmaceutical Preparations;Phase;Phenotype;Play;pre-clinical;preclinical study;Prevention;Productivity;Publications;Recommendation;Research;research clinical testing;Research Personnel;Research Project Grants;Research Support;Role;success;Syndrome;System;therapeutic development;Trademark;translational therapeutics;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Core B:  University of Kentucky Alzheimer's Disease Core Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: ABNER, ERIN  (contact)

PROJECT_TERMS: Advisory Committees;Aging;Alzheimer's Disease;Alzheimer's Disease Core Center;Applications Grants;Attention;Bioinformatics;Biological Markers;Biometry;central database;Clinical;Clinical Data;Clinical Trials;Clinical Trials Data Monitoring Committees;Cognitive;cohort;Collaborations;Communities;COVID-19 pandemic;dashboard;Data;Data Analyses;Data Collection;data dictionary;data integration;data management;data warehouse;Dementia;Development;direct application;doctoral student;Education;Education and Outreach;education research;Elderly;electronic data capture system;Elements;Enrollment;Environment;Epidemiology;Etiology;Evaluation;Event;Experimental Designs;Extramural Activities;Faculty;Funding;Generations;Genetic;Gerontology;improved;Information Systems;innovation;interest;Interruption;Kentucky;late life;Leadership;Life;Literature;Manuscripts;meetings;member;Methodology;Mission;mixed dementia;Neuroepidemiology;neuropathology;novel;Observational Study;Online Systems;outreach;Participant;Pathology;Pilot Projects;Procedures;Productivity;programs;Psychology;Public Health;Publications;recruit;Reporting;Research;Research Design;Research Methodology;Research Personnel;Resources;Risk Factors;Role;Sampling;Seasons;Services;Statistical Data Interpretation;statistics;student training;Study Section;success;System;Tablets;Time;Training;Universities;user-friendly;Vision;web app;web platform;web site

PROJECT_TITLE: Core C:  University of Kentucky Alzheimer's Disease Core Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: NELSON, PETER T. (contact)

PROJECT_TERMS: Address;age related;age related neurodegeneration;Aging;aging brain;alpha synuclein;Alzheimer's Disease;Alzheimer's Disease Core Center;Area;Autopsy;Biological;Biological Markers;Biological Specimen Banks;Biometry;blood product;Brain;Brain Diseases;Brain imaging;Brain region;brain tissue;Caring;Catalogs;Cerebrospinal Fluid;Cerebrovascular Disorders;cerebrovascular pathology;Cerebrum;Clinical;clinical center;Clinical Trials;Cognitive;cohort;Collaborations;Consensus;Correlation Studies;Correlative Study;Data;data management;Databases;demented;Dementia;Dementia with Lewy Bodies;Deposition;Diagnosis;Diagnostic;digital;digital pathology;Disease;DNA;Down's Syndrome;Education;Ensure;Etiology;Evaluation;experience;Freezing;Frontotemporal Lobar Degenerations;Genetic;Genetic study;genome wide association study;Genomics;Goals;hippocampal sclerosis;Impaired cognition;Individual;Infrastructure;innovation;Investigation;Kentucky;Laboratory Research;late life;Lesion;limbic-predominant age-related TDP-43 encephalopathy;meetings;Memory;Methodology;Methods;Mission;mixed dementia;Nerve Degeneration;Neurofibrillary Tangles;neuroinflammation;neuropathology;novel;Oxidative Stress;Pathologic;Pathology;Patients;Plasma;pre-clinical;Preventive measure;Process;protein TDP-43;Protocols documentation;Publishing;religious order study;Research;Research Personnel;Research Support;Resources;Running;Sampling;Senile Plaques;Serum;Services;Specimen;Staging;Standardization;statistics;symposium;Syndrome;synucleinopathy;System;tau Proteins;Tauopathies;Therapeutic;Thinness;Tissue Banks;Tissue Sample;Tissues;tool;Universities;Work

PROJECT_TITLE: Core D:  University of Kentucky Alzheimer's Disease Core Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SCHMITT, FREDERICK  (contact)

PROJECT_TERMS: Address;African American;African American population;Aging;Agreement;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease related dementia;American;Autopsy;Awareness;Biological Markers;Brain;Brothers;Caring;Catchment Area;Censuses;Cessation of life;checkup examination;Church;Clinic;Clinical;clinical examination;Clinical Research;Clinical Trials;Cognitive;cohort;Collaborations;Communities;community engagement;Consent;Data;Databases;Dementia;dementia risk;demographics;Development;Disease;disparity reduction;Education;effectiveness evaluation;efficacy evaluation;Elderly;Elements;Enrollment;ethnic minority population;ethnoracial;Etiology;Event;Extramural Activities;Faith-based organization;Fostering;Foundations;Genetic;Goals;Grant;health disparity;health literacy;Health Promotion;Healthcare;improved;innovation;Institution;International;Kentucky;late life;Lead;Link;Longitudinal cohort;Measures;meetings;Minority;Minority Groups;Mission;mixed dementia;Neck;neuropathology;Outcome;outreach;outreach program;Participant;participant retention;Pathology;patient engagement;Play;programs;Protocols documentation;racial minority population;recruit;Reporting;Research;Research Activity;research study;Research Support;Resources;response;Risk;Risk Assessment;Role;success;System;Testing;Therapeutic Trials;Time;Underrepresented Populations;Universities;Update;volunteer;willingness;Work

PROJECT_TITLE: Core E:  University of Kentucky Alzheimer's Disease Core Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: WILCOCK, DONNA M (contact)

PROJECT_TERMS: Adopted;aging population;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer’s disease biomarker;Biological Markers;biomarker development;biomarker identification;biomarker performance;Blood;blood-based biomarker;Brain Pathology;Cerebral small vessel disease;clinic ready;Clinical;Cognitive;cohort;Collection;Complex;Consensus;Data;Dementia;digital;Digital biomarker;Disease;Etiology;Gait;Goals;Image;Impaired cognition;Individual;Inflammation;insight;interest;International;Ischemia;Kentucky;late life;Lewy Body Dementia;Lewy body pathology;Liquid substance;Longitudinal cohort;Magnetic Resonance Imaging;Measures;meetings;Modality;MRI Scans;multimodality;neuroinflammation;normal aging;novel;novel marker;Participant;Pathologic;Pathology;Physical activity;Plasma;Positron-Emission Tomography;precision medicine;Research;Research Project Grants;Role;Sleep;Sleep disturbances;Standardization;System;Universities;wearable device

PROJECT_TITLE: Core F:  University of Kentucky Alzheimer's Disease Core Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

PROJECT_TERMS: Acceleration;Achievement;Address;Advisory Committees;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease related dementia;Area;Basic Science;Behavioral;Biological Markers;career;career development;Clinical;Clinical Research;Clinical Trials Design;collaborative environment;Communities;Competence;Data Analyses;Dedications;Dementia;Development;Discipline;Early Diagnosis;Education;education planning;education research;Educational Activities;Environment;Etiology;experience;Exposure to;Faculty;Foundations;Funding;Future;Goals;health inequalities;health literacy;high school;Image;improved;Individual;innovation;instrument;Interdisciplinary Study;investigator training;Kentucky;Knowledge;late life;Leadership;Learning;Liquid substance;longitudinal analysis;Magnetic Resonance Imaging;Mentors;mixed dementia;Monitor;multidisciplinary;neuropathology;next generation;novel;Outcome;Participant;Postdoctoral Fellow;prevent;Prevention Research;Process;professor;Program Development;programs;Recording of previous events;recruit;Research;Research Design;Research Personnel;Research Project Grants;Resources;Scholars Program;Science;Scientist;skill acquisition;skills;Standardization;Structure;success;System;Teacher Professional Development;therapy development;Training;training opportunity;Training Programs;Translational Research;treatment research;undergraduate student;Universities

PROJECT_TITLE: Core G:  University of Kentucky Alzheimer's Disease Core Center


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Disability Research;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention

PHR: PROJECT NARRATIVE Disease course in people with multiple sclerosis (MS) is highly heterogeneous. The overall goal of this research study is to evaluate whether certain metabolic changes characterized using metabolomics predict MS prognosis and explore potential contributing mechanisms using a data-driven approach.

PI_NAMEs: FITZGERALD, KATHRYN C. (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: amino acid metabolism;Amino Acids;Aromatic Amino Acids;Biological;Biological Markers;biomarker discovery;biomarker identification;Central Nervous System Diseases;Characteristics;Clinical;Clinical Trials;Clinical/Radiologic;cohort;Collection;Complex;Data;Data Set;design;disability;disabled;Disease;Disease Outcome;Disease Progression;disorder risk;Environmental Exposure;epidemiological model;Evolution;experience;Foundations;Funding;Future;Goals;gut microbiota;Heterogeneity;immunoregulation;improved;Individual;Inflammatory;innovation;insight;Intervention Studies;Investigation;Light;Link;Machine Learning;Measures;Mediating;Mediation;Mediator;Metabolic;Metabolic Pathway;metabolic phenotype;metabolic profile;Metabolism;metabolome;metabolomics;Methods;multiple datasets;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Neurodegenerative Disorders;neurofilament;new therapeutic target;novel;novel marker;Outcome;Outcome Assessment;Pathway interactions;Persons;Phenylalanine;predictive modeling;Predictive Value;primary outcome;Production;Prognosis;prospective;radiological imaging;Radiology Specialty;Randomized;research study;Resources;response;Sampling;Serum;Severity of illness;small molecule;Specific qualifier value;Standardization;statistical learning;Structure;Symptoms;Techniques;Technology;Time;tool;Translating;Tryptophan;Tyrosine;United States National Institutes of Health;Validation

PROJECT_TITLE: Metabolic predictors of disease outcomes in multiple sclerosis

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]