NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Infant Mortality;Machine Learning and Artificial Intelligence;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE: The proposed research is relevant to public health because hypoplastic left heart syndrome (HLHS) is a severe form of congenital heart disease with 10-year survival of just 40%, and currently only 6% of HLHS patients have a likely genetic cause identified on exome sequencing. As epidemiologic evidence suggests genetic risk contributes to the majority of congenital heart disease, I propose that use of machine learning functional assessment of extensive variants of unknown significance from genomic sequencing and is an important next step in understanding HLHS. Identifying new genetic causes of HLHS can lead to better diagnosis and treatment of HLHS patients, as well as individuals with other congenital anomalies, and thus this proposal is relevant to NIH's goal of fostering fundamental creative discoveries as a basis for ultimately protecting and improving health.

PI_NAMEs: MORTON, SARAH UHLER (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: 3-Dimensional;Affect;Attenuated;Biological;Biological Assay;Cardiac;Cardiac Myocytes;cardiogenesis;career;Cell Differentiation process;congenital anomaly;congenital heart abnormality;Creativeness;Data;Defect;Development;Developmental Biology;Diagnosis;Disease;Disease Clusterings;Endothelial Cells;Endothelium;Enhancers;Enterochromaffin Cells;Epidemiology;exome sequencing;Exons;Fostering;Frequencies;functional genomics;Gene Expression;Genes;Genetic;Genetic Risk;Genome;genome editing;genome sequencing;genome-wide;Genomics;Genotype;Goals;Health;heart disease risk;Human;human disease;human induced pluripotent stem cells;Hypoplastic Left Heart Syndrome;improved;Individual;induced pluripotent stem cell;Infant;insight;Knowledge;Left;Left ventricular structure;Linear Models;Location;Longevity;loss of function;Machine Learning;Measures;Messenger RNA;Modeling;Molecular;mortality;NOTCH1 gene;novel;Nucleic Acid Regulatory Sequences;Obstruction;Participant;Pathogenicity;Pathway interactions;Patients;Phenotype;Physicians;pluripotent stem cell differentiation;programs;protein expression;Protein Isoforms;protein structure;Public Health;rare variant;Regulation;Regulatory Element;Reporter;Research;Risk;RNA;RNA Splicing;Role;role model;Scientist;Severity of illness;skills;Tertiary Protein Structure;Testing;Tissues;Training;transcription factor;United States National Institutes of Health;Untranslated RNA;Variant;variant of unknown significance;Ventricular;Work

PROJECT_TITLE: Integration of RNA and Genome Sequences to Identify Genetic Risk in Hypoplastic Left Heart Syndrome

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Immunization;Immunotherapy;Radiation Oncology;Skin Cancer;Vaccine Related

ORG_CITY: TUCSON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE High incidence and poor treatment options for cutaneous squamous cell carcinoma in immunosuppressed solid organ transplant recipients have led to an important unmet clinical need. The proposed research will compare the mutated peptides in cutaneous squamous cell carcinoma from immunosuppressed and immunocompetent individuals to test an innovative approach to cancer immunotherapy.

PI_NAMEs: BORDEN, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Actinic keratosis;Antigen Presentation;Antigen Presentation Pathway;Area;Binding Proteins;cancer cell;cancer immunotherapy;Cancer Model;Cancer Vaccines;Carcinogen exposure;Cell Fraction;Cell Physiology;checkpoint inhibition;Clinical;Cytoprotection;Data;Development;efficacy testing;Genetic;high risk;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunocompetent;Immunocompromised Host;immunogenic;immunogenicity;Immunologist;immunosuppressed;Immunotherapy;Incidence;Individual;innovation;Irradiated tumor;Laboratories;Lesion;Light;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Mentorship;MHC Class I Genes;Missense Mutation;Modeling;Mus;Mutate;neoantigen vaccine;neoantigens;neoplastic cell;novel strategies;Nude Mice;organ transplant recipient;Pathway interactions;Patients;Peptides;personalized cancer vaccines;preservation;Process;Recurrence;Research;Resistance;response;Role;Shapes;Skin;Skin Cancer;skin squamous cell carcinoma;Solid;Systemic Therapy;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Tacrolimus;targeted treatment;Testing;Tissues;transplant model;Transplant Recipients;Transplantation;tumor;Vaccination;vaccine efficacy;vaccine evaluation;Vaccines;Work

PROJECT_TITLE: Immunoediting in Cutaneous Squamous Cell Carcinoma


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Mental Health;Nutrition;Patient Safety;Physical Activity;Prevention;Rehabilitation;Telehealth

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Most patients with heart failure struggle to adhere to behaviors important for heart health, and existing interventions to encourage these health behaviors have had limited impact and do not focus on psychological factors associated with adherence. In the proposed trial, we aim to determine whether a 12-week, telephone- delivered, behavioral intervention that involves performing simple activities to enhance well-being and setting goals for healthy behaviors—with additional text message support for 24 weeks—helps patients with heart failure take medications, maintain a healthy diet, and be more physically active. If the intervention is successful at improving adherence, we will plan a larger trial to determine whether the intervention reduces hospitalizations and improves survival in this group of high-risk patients.

PI_NAMEs: CELANO, CHRISTOPHER M (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Accelerometer;Adherence;Affect;Algorithms;Ambulatory Care Facilities;American;Anxiety;Attention;Behavior;behavior change;Behavior Therapy;Blood Pressure;Body mass index;Cardiac;Cardiac health;Cardiac rehabilitation;Cardiology;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Chronic;Clinical;Clinical Trials;comorbidity;Complex;compliance behavior;Control Locus;Counseling;Death Rate;Diagnosis;Diet;dietary adherence;Disease Progression;Education;effective intervention;efficacy evaluation;efficacy testing;Electronics;Event;flexibility;Fostering;functional outcomes;Glucose;Goals;good diet;gratitude;Health;Health behavior;health related quality of life;Healthcare;Heart;heart disease risk;Heart failure;high risk population;hospital readmission;Hospitalization;Impaired health;Impairment;improved;Individual;innovation;Intake;Intention;Intervention;intervention effect;intervention refinement;Letters;Lipids;Measures;Medical;medication compliance;Mental Depression;Mental Health;Minority;Modeling;moderate-to-vigorous physical activity;Monitor;mortality;Motivation;motivational enhancement therapy;New York;novel;optimism;Outcome;Outcome Study;Patients;Personal Satisfaction;Pharmaceutical Preparations;Physical activity;pill;pilot trial;Population;primary outcome;programs;prospective;psychologic;Psychological Factors;psychological outcomes;Psychology;Quality of life;Randomized;randomized trial;randomized, clinical trials;Regimen;Research;Self Care;Self Efficacy;skills;Sodium;Sodium-Restricted Diet;Standardization;Symptoms;System;telephone delivery;Testing;Text Messaging;texting support;Time;Treatment Efficacy;Treatment Failure;United States National Institutes of Health;urinary;Well in self;Writing

PROJECT_TITLE: A novel behavioral intervention to promote adherence in heart failure

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative This application is for support of a comprehensive training program for postdoctoral trainees to become experts in different aspects of magnetic resonance imaging (MRI) and spectroscopy (MRS) to be able to contribute to their translational applications. MRI and MRS are very important methods for the non-invasive diagnosis of diseases and monitoring of treatment in clinical practice, and provide vital information for a wide range of other biomedical research applications. This program will address the shortage of suitably qualiﬁed postdoctoral scientists able to contribute to the further development of MR methods or to apply them effectively.

PI_NAMEs: GORE, JOHN C (contact)

PROGRAM_OFFICER_NAME: ERIM, ZEYNEP

PROJECT_TERMS: Magnetic Resonance Imaging;post-doctoral training

PROJECT_TITLE: Postdoctoral Training in Biomedical MRI and MRS


NIH_SPENDING_CATS: Cardiovascular;Diabetes;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: RELEVANCE TO PUBLIC HEALTH Our studies are relevant to the treatment of disease of the vessels in diabetic patients. This study focuses on the inhibition of cyclin-dependent kinase 1, and how it prevents the hardening of the vessels. Understanding how these work may lead to new strategies for the treatment.

PI_NAMEs: YAO, YUCHENG  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Activities of Daily Living;Affect;American;Aorta;Back;bone cell;calcification;CDC2 gene;Cell Proliferation;Cells;Complications of Diabetes Mellitus;Cyclin-Dependent Kinase Inhibitor;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Disease;effective therapy;Endothelial Cells;Endothelium;Genetic;Genetic Transcription;high risk;improved;inhibitor;Investigation;Label;Maps;matrix Gla protein;Mesenchymal;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;novel strategies;novel therapeutic intervention;Osteoblasts;Osteogenesis;osteogenic;osteoprogenitor cell;Patients;Persons;prevent;Process;Protein Deficiency;Proteins;Public Health;Resolution;single-cell RNA sequencing;Source;Specificity;Testing;Therapeutic;Tissues;Variant;Vascular calcification;Vascular Diseases;Vascular Endothelial Cell;Vascular Endothelium;Work

PROJECT_TITLE: Switch of Osteogenesis in Vascular Calcification

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Medically underserved patients have the highest burden of multiple chronic conditions and are at increased risk for poor outcomes during and after cancer treatment. As medically underserved complex cancer patients may lack healthcare knowledge and access to supportive care, their health outcomes and care transitions might be improved by enhancing communication and collaboration between their oncologists and primary care providers (PCPs). This study tests and evaluates a novel shared care model for complex cancer survivors called OPTIMISE that shifts the timing of thinking about survivorship to point of diagnosis and seeks to develop a clinical infrastructure to support continuity of care from cancer diagnosis through post-treatment survivorship.

PI_NAMEs: BADR, HODA J. (contact);MIMS, MARTHA P

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Accident and Emergency department;active method;Address;Adherence;Adoption;Affect;Aftercare;Area;Attitude;Baseline Surveys;breast cancer diagnosis;cancer care;cancer diagnosis;Cancer Patient;cancer risk;Cancer Survivor;Cancer Survivorship;cancer therapy;care coordination;care systems;Caring;Chronic;chronic care model;Chronic Disease;Clinic Visits;clinical care;clinical infrastructure;clinical practice;Clinics and Hospitals;Collaborations;collaborative care;Communication;comorbidity;Complex;Comprehensive Health Care;Continuity of Patient Care;Data;Diagnosis;Disease Management;Disease-Free Survival;ethnic minority;experience;Face;Feedback;follow-up;Future;Goals;Guidelines;Health;health care service utilization;Healthcare;Healthcare Systems;Hematologic Neoplasms;implementation outcomes;improved;Individual;Interruption;Interview;Knowledge;Late Effects;Life Style Modification;Low income;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Medical;medical specialties;medically underserved;Methods;Modeling;Monitoring for Recurrence;multiple chronic conditions;Newly Diagnosed;novel;Nurses;Oncologist;Oncology;Oncology Nurse;Outcome;Outcome Assessment;Pathway interactions;patient subsets;Patients;prevent;Preventive care;Primary Care;primary care provider;primary outcome;Process;Protocols documentation;Provider;provider communication;Psychosocial Assessment and Care;Public Hospitals;Qualitative Evaluations;Quality of life;racial minority;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recurrence;Reporting;Research;Resource-limited setting;Risk;risk stratification;safety net;scale up;Second Primary Cancers;secondary outcome;Self Management;Structure;Supportive care;Surveillance Modeling;survivorship;System;Testing;Thinking;Time;Translations;trend;Uninsured;uptake;Visit

PROJECT_TITLE: OPTIMISE: A Shared Care Approach for Improving Comprehensive Care of Cancer Patients with Comorbidities in A Safety-Net System


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Electronic Nicotine Delivery Systems;Genetics;Prevention;Rare Diseases;Tobacco;Tobacco Smoke and Health

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative: Understanding the potential health effects of electronic cigarettes is of tremendous interest because: (a) they are the most used tobacco product among youth, and are used by over one third of adult tobacco smokers (dual users); (b) they contain unique constituents that might have unforeseen health consequences; and (c) they might be an important tool for smoking cessation. In this proposal, we will determine how the use of electronic cigarettes by exclusive and dual users modifies DNA damage, mutation rate, and gene expression, factors which increase cancer risk in humans. Our study will provide evidence-based data urgently needed by clinicians to guide their patients and by regulatory agencies to implement specific policies aiming to protect public health.

PI_NAMEs: QUEIMADO, LURDES  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Adult;Aerosols;Animal Model;Antioxidants;Bioinformatics;Biological;Biological Assay;cancer initiation;cancer risk;Carcinogens;Cell Death Signaling Process;Chemicals;cigarette smoke;Cigarette Smoker;cigarette user;Collecting Cell;combustible cigarette;combustible tobacco;Complex;Data;Data Analyses;Deposition;detection assay;DNA Adducts;DNA Damage;DNA Repair;DNA Repair Enzymes;DNA Sequence Alteration;Dose;e-cigarette aerosols;Electronic cigarette;electronic cigarette use;electronic cigarette user;evidence base;Gene Expression;Gene Expression Profile;genotoxicity;Harm Reduction;Health;Health Policy;Human;In Vitro;in vivo;in vivo evaluation;Individual;Inflammatory;interdisciplinary approach;interest;Knowledge;Laboratories;Lead;Lesion;Literature;malignant mouth neoplasm;Measures;Methods;multidisciplinary;Mutation;novel;Oklahoma;Oncogenic;Oral;Oral cavity;Oral mucous membrane structure;Participant;Particle Size;Pathway interactions;Patients;Phenotype;Policies;Property;Public Health;Publishing;Reactive Oxygen Species;recruit;Regulation;Reporting;Smoking;smoking cessation;Testing;Tobacco;Tobacco smoke;tobacco smokers;Tobacco smoking behavior;Tobacco use;tobacco user;tool;toxicant;transcriptome;transcriptome sequencing;tumor progression;user protection;vaping;Youth

PROJECT_TITLE: Biological impact of exclusive and dual e-cigarette use on oral cancer risk


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases;Lung;Lymphatic Research;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative The opportunistic fungal pathogen Aspergillus fumigatus poses an increasing health concern for critically ill and immunodeficient patients due to widespread anti-microbial resistance. This proposal seeks to investigate the role of lymph node stromal cells in organizing spatial niches for generating diverse adaptive immune responses to A. fumigatus. Understanding the mechanisms by which lymph node stromal cells orchestrate protective immunity may identify novel strategies for development of therapies and vaccines to mitigate the burden of A. fumigatus and other fungal pathogens.

PI_NAMEs: MAI, CHERYL  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: adaptive immune response;adaptive immunity;Adoptive Transfer;Affect;Allergic Bronchopulmonary Aspergillosis;Anatomy;anti-fungal agents;Antigen-Presenting Cells;Antigens;Antimicrobial Resistance;Aspergillosis;Aspergillus;Aspergillus fumigatus;CCL20 gene;CCR6 gene;CD4 Positive T Lymphocytes;Cell Communication;Cell Differentiation process;Cell Physiology;cell type;Cells;chemokine;chemokine receptor;Chronic;clinically relevant;Competence;confocal imaging;Critical Illness;Cues;CXCL10 gene;CXCL9 gene;CXCR3 gene;cytokine;Data;Death Rate;design;Development;dimensional analysis;Disease;Dissection;Dissociation;draining lymph node;Effector Cell;effector T cell;Environment;Epigenetic Process;Exhibits;experience;Gene Targeting;Genetic;Goals;Health;Host Defense;Human;human disease;Image Analysis;imaging approach;Immune;Immune response;Immune System Diseases;Immunity;Immunobiology;immunodeficiency;Immunofluorescence Immunologic;Immunofluorescence Microscopy;immunomodulatory strategy;improved outcome;Infection;Inflammatory;insight;Knowledge;Life;Ligands;lymph node microenvironment;lymph nodes;Lymphocyte;Lymphoid Tissue;Maps;Mediastinal lymph node group;member;memory retention;Methods;Microscopy;Modification;Molecular;mouse model;Mus;Mycoses;Neighborhoods;novel;novel strategies;novel therapeutic intervention;pathogen;pathogenic fungus;Patients;Pattern;Physicians;Population;Positioning Attribute;Primary Infection;Process;Property;Proteins;receptor;Resolution;Respiratory Tract Infections;response;Reticular Cell;Role;Scientist;secondary lymphoid organ;segregation;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Source;spatiotemporal;Stromal Cells;System;T cell differentiation;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;therapy development;tool;trafficking;Training;transcriptomic profiling;transcriptomics;vaccine development;Vaccines

PROJECT_TITLE: Lymph node stromal cells coordinate immune cell environments during Aspergillus fumigatus infection


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Narrative This NRSA F30 fellowship will provide an invaluable and comprehensive training opportunity for a future physician scientist as she develops into an emerging leader in the field of HIV/alcohol research and neurology. These studies investigate the contribution of glucocorticoid signaling to interactions between alcohol use and pain in the context of HIV. Findings from this research will provide mechanistic insight for future translational studies and therapeutic applications aimed at alleviating HIV- and alcohol use disorder (AUD)-associated pain.

PI_NAMEs: FITZPATRICK-SCHMIDT, TAYLOR  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Acute;Affect;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol research;alcohol risk;alcohol use disorder;Alcohols;Analgesics;Animal Model;Animals;antagonist;Area;ARHGEF5 gene;Behavior;Brain;career;career development;Chronic;Chronic Disease;chronic pain;cingulate cortex;Clinical;cohort;comorbidity;Data;Development;Disease Progression;disorder risk;drinking;Emotions;Ensure;Ethanol;Exposure to;Fellowship;Future;Genetic Transcription;Glucocorticoid Receptor;Glucocorticoids;Glycoproteins;Heavy Drinking;high risk drinking;HIV;HIV envelope protein;HIV neuropathy;HIV/AIDS;hormonal signals;Hormones;Hydrocortisone;hydrocortisone receptor;Hyperalgesia;Inflammation;insight;Investigation;Link;Literature;Measures;Mechanics;Mediating;Medicine;Mentors;Methods;Mifepristone;Modeling;Molecular;National Research Service Awards;negative affect;negative emotional state;Nerve;Nervous System;Neurology;Neuronal Plasticity;Neurons;Neuropathy;Nociception;Pain;pain sensitivity;pain symptom;painful neuropathy;Pathogenesis;Patient Self-Report;Pattern;perineural;Peripheral;Peripheral Nerves;Persons;phosphatidylethanol;Phosphorylation;Physicians;Play;Population;pre-clinical;Pre-Clinical Model;Prevalence;Property;Rattus;Receptor Signaling;Recording of previous events;Reporting;Research;Rodent Model;Role;Scientist;Self Administration;Self Medication;sensory neuropathy;Signal Transduction;stem;Stress;Symptoms;Techniques;Testing;Toxic effect;Training;training opportunity;translational physician;translational study;translational therapeutics;United States National Institutes of Health;vapor;Viral Proteins;Western Blotting;Work

PROJECT_TITLE: Interactions of Alcohol and Pain in the Context of HIV


PHR: While there are unprecedented opportunities for advancement in understanding of the fundamental mechanisms of lung diseases, the pipeline of new investigators who are trained and committed to careers in lung disease-oriented biomedical research is inadequate. This interdisciplinary training program is designed to meet this challenge by preparing future leaders in lung research to advance science and improve respiratory health.

PI_NAMEs: PEEBLES, RAY STOKES (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Lung;Research;Training Programs

PROJECT_TITLE: Interdisciplinary Training Program in Lung Research


NIH_SPENDING_CATS: Hematology;Pediatric

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Research in hematology has yield important knowledge about fundamental biological processes and has improved the survival and quality of life for persons with blood diseases. Great strides have been made in the treatment of children with sickle cell disease, hemophilia, bone marrow failure and other blood disorders. Yet the number of well-trained researchers in this field is steadily declining, especially in pediatrics. This T32 Training Grant is designed to address this problem by providing high quality research training to highly motivated and talented post-doctoral MD, MD/PhD, and PhD researchers to enable them to become the next generation of physician scientists and translational investigators in pediatric non-malignant hematology.

PI_NAMEs: JOINER, CLINTON H;MEEKS, SHANNON L. (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TITLE: Research Training in Pediatric Non-Malignant Hematology

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: JEFFERSON CITY

ORG_NAME: MISSOURI STATE DEPT/ HEALTH & SENIOR SRV

ORG_STATE: MO

PHR: Missouri Department of Health and Senior Services  State Public Health Laboratory  FOA PAR-20-105  Laboratory Flexible Funding Model Grant Narrative: The Missouri Department of Health and Senior Services (DHSS) State Public Health Laboratory (MSPHL) seeks FDA cooperative agreement funding to increase capability and capacity in food testing areas where FDA has identified specific needs. The expected outcome will be to protect the safety of the food supply and further increase public health. This grant will strengthen and improve the collaboration of surveillance testing activities between the FDA, the Missouri MFRPS, and the MSPHL. Thus, advancing a national integrated food safety system. Page 1 of 1

PI_NAMEs: BAUER, JESSICA ;LUEBBERING, LEON  (contact);RUSTEMEYER, MINDY ;SCHAFFER, ALAN

PROGRAM_OFFICER_NAME: LI, MEI-YING

PROJECT_TITLE: Laboratory Flexible Funding Model


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT RELEVANCE The malignant transformation of slow-growing low grade brain tumors into lethal high grade tumors is a devastating event that eventually affects nearly all patients. We discovered that while the mutations in low grade tumors suppress the ability of the local immune system, the mutations that cause malignant transformation might relieve key elements of the suppression, creating an environment that could be more favorable to immune system attack, given the appropriate stimulation by immunotherapy in combination with agents targeting genetic effectors of immunosuppression. We propose to understand how and why the initially immunosuppressed state of the tumor changes during malignant transformation, and use this knowledge to improve immunotherapy, and immunotherapies combined with targeted agents, to prevent, delay or treat malignant transformation.

PI_NAMEs: COSTELLO, JOSEPH F (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: 3-Dimensional;Address;Adrenal Cortex Hormones;Affect;Alleles;alpha-beta T-Cell Receptor;Amino Acid Sequence;Anatomy;antigen-specific T cells;Biological Assay;Brain Neoplasms;cancer genome;CD8-Positive T-Lymphocytes;cell type;Cells;Cellular immunotherapy;Cessation of life;chemokine;Clinical;clinically significant;Clonality;Clone Cells;cohort;Collaborations;Combination immunotherapy;Cytometry;Cytotoxic T-Lymphocytes;Data;design;DNA Sequence Alteration;Elements;Environment;Event;Evolution;exome sequencing;experimental study;Expression Profiling;Failure;fitness;Gene Expression;Genetic;genetic effector;Genomics;Glioma;Goals;Immune;immune cell infiltrate;Immune system;Immunogenomics;Immunohistochemistry;Immunologic Factors;Immunologics;immunosuppressed;Immunosuppression;Immunotherapy;improved;Individual;Knowledge;Location;Loss of Heterozygosity;Malignant - descriptor;Maps;Mediating;mutant;Mutation;neoantigens;neoplastic cell;Newly Diagnosed;novel;Other Genetics;Patients;personalized medicine;prevent;Production;Publishing;Recurrence;Recurrent tumor;Role;Route;Sampling;Source;Specificity;STAT1 gene;synergism;T cell infiltration;T cell therapy;T-Cell Receptor;T-Lymphocyte;targeted agent;targeted treatment;Testing;Therapeutic;Time;transcriptome sequencing;tumor;tumor heterogeneity;tumor-immune system interactions;Validation

PROJECT_TITLE: 3-D spatial approach to discover genomic effectors of immunosuppression during malignant transformation

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Dietary Supplements;Genetics;Hematology;Nutrition;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: GENETICS

PHR: Acute myeloid leukemia (AML) is the most common acute leukemia in adults with a devastating prognosis for elderly patients. We discovered an unexpected role of selenium metabolism in AML, and we will interrogate this mechanism in animal models and patient samples to examine whether we could therapeutically target this mechanism to treat AML. Our study may lead to a novel combinatorial therapy that could deeply suppress AML.

PI_NAMEs: NAKADA, DAISUKE  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Affect;Age;Amino Acids;Anabolism;Animal Model;Antioxidants;Attenuated;attenuation;Binding;Bioinformatics;Biological Assay;Cell Death;Cell Line;Cells;chemotherapy;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;combinatorial;conditional knockout;Coupled;CRISPR screen;CRISPR/Cas technology;Data;Databases;Dedications;Dependence;Diet;Diet therapy;dietary;dietary manipulation;Dietary Selenium;Dropout;Drug Metabolic Detoxication;Enhancers;feeding;FLT3 gene;Gene Deletion;Genes;genetic analysis;genetic approach;glutathione peroxidase;Hand;Hematopoiesis;Homeostasis;Human;improved;in vivo;insight;interest;Knockout Mice;leukemia treatment;leukemogenesis;Lipid Peroxidation;Lipid Peroxides;Maintenance;Malignant Neoplasms;Metabolic;Metabolism;MLL-AF9;Modeling;mouse model;Mus;Mutation;novel;novel strategies;novel therapeutics;older patient;Organism;Oxidation-Reduction;Oxidative Stress;Pathway interactions;patient derived xenograft model;Patients;polypeptide;Production;Prognosis;protein expression;Regulation;Role;Sampling;Selenium;selenium deficiency;Selenocysteine;selenoprotein;Testing;Therapeutic;therapeutic target;thioredoxin reductase;Trace Elements;transcription factor;Translations;Transplantation;whole genome;Xenograft procedure

PROJECT_TITLE: THE ROLE OF SELENOPROTEIN SYNTHESIS PATHWAY IN ACUTE MYELOID LEUKEMIA

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Bioengineering;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Nanotechnology;Prevention;Rare Diseases

PHR: Project Narrative Among the different tumor liquid biopsy approaches, extracellular vesicles (EVs) are present in circulation at a relatively early stage of disease of hepatocellular carcinoma (HCC). The long-term goal of this R01 proposal is to develop a new HCC EV purification system (i.e., EV Click Chips) by synergistically integrating four very innovative approaches. The successful development of the proposed EV Click Chips will enable more sensitive and specific HCC EV-based molecular assays for HCC surveillance and will be rapidly translatable to the fields of oncology and cancer biology.

PI_NAMEs: AGOPIAN, VATCHE ;TSENG, HSIAN-RONG  (contact);YOU, SUNGYONG

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Address;Adopted;Alcoholic Liver Diseases;anti-cancer research;Antibodies;Area;assay development;Bioinformatics;Biological Assay;Biological Markers;Biology;Biometry;Blood;Blood specimen;Cancer Biology;cancer diagnosis;Cancer Etiology;Cells;Cessation of life;Chemistry;Circulation;Cirrhosis;Clinical;Clinical Oncology;Couples;Coupling;Curative Surgery;curative treatments;Data;Death Rate;Development;Devices;Diagnosis;Diagnostic;diagnostic algorithm;diagnostic biomarker;digital;Disease;Disease Progression;Disulfides;early detection biomarkers;Early Diagnosis;Early Intervention;Etiology;Excision;Exhibits;extracellular vesicles;Filtration;Goals;Hepatic;Hepatitis B;Hepatitis C;Heterogeneity;in-vitro diagnostics;Incidence;innovation;Intervention;Joints;liquid biopsy;Liver;Liver Cirrhosis;liver transplantation;Malignant Neoplasms;Mediating;Medical center;Messenger RNA;Methods;microchip;Microfabrication;Microfluidics;Minor;Modality;Molecular;Molecular Analysis;molecular pathology;Molecular Profiling;mortality;Motivation;nano;nanomaterials;Nanostructures;nanowire;Neoplasm Circulating Cells;neoplastic cell;non-alcoholic fatty liver disease;novel marker;Oncology;particle;Patients;Performance;Phospholipids;Plasma;Postoperative Period;Precipitation;Primary carcinoma of the liver cells;Prognostic Marker;Quantitative Evaluations;radiological imaging;Recovery;Recurrence;Research;Reverse Transcription;Risk;Sampling;Serum;Silicon;Specific qualifier value;Surface;System;Technology;Transcript;tumor;tumor DNA;Tumor-Derived;Ultracentrifugation;Validation;vesicular release;α-Fetoproteins

PROJECT_TITLE: Covalent Chemistry on Nanosubstrates Enables Molecular Analysis of Purified Extracellular Vesicles in Hepatocellular Carcinoma


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Genetics

ORG_CITY: MADISON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative A clear diagnostic of type 2 diabetes is amyloid deposits in the pancreas. Recent research suggests that it is not the deposits themselves that cause β-cell failure and the loss of insulin production, but rather their formation. The aim of this proposal is to study the transient species that causes cytotoxicity. That knowledge is critical to combat the disease and develop new hormone replacement therapies.

PI_NAMEs: ZANNI, MARTIN T (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: aggregation pathway;Alanine;American;Amyloid;Amyloid fibers;Amyloid Fibrils;amyloid formation;Animal Model;Apoptosis;Benign;Beta Cell;beta pleated sheet;Biochemical;Biological Assay;Blood Glucose;Cell Membrane Permeability;Collaborations;combat;Contracts;Cryoelectron Microscopy;cytotoxic;cytotoxicity;Data;Deposition;design;Diabetes Mellitus;diabetic;Diagnostic;Disease;Economics;Excretory function;Exhibits;experimental study;Failure;Genetic;Genetic Polymorphism;glucose tolerance;Grant;Hand;Homeostasis;Hormone replacement therapy;Hormones;Hour;Human;human tissue;humanized mouse;Image;Impairment;improved;In Vitro;in vivo;Individual;inhibitor;insight;Insulin;Insulin Resistance;interest;invention;Investigation;islet;islet amyloid polypeptide;Islets of Langerhans Transplantation;Isotope Labeling;Kinetics;Knock-in Mouse;Knowledge;Laboratories;Link;Location;Malignant Neoplasms;Mediating;Metabolism;Microscopy;Modeling;Monitor;mouse model;Mus;mutant;Mutation;NMR Spectroscopy;Non-Insulin-Dependent Diabetes Mellitus;Pancreas;pancreas imaging;Pathway interactions;Physiological;Physiology;Play;Polymorph;Population;prevent;Process;Production;Proteins;Publishing;receptor;Reporting;Research;Research Personnel;Role;Senile Plaques;Series;Sorting;Spectrum Analysis;Stable Populations;structural biology;Structure;Structure of beta Cell of islet;Techniques;Technology;Testing;Thinking;Tissue imaging;Tissues;tool;Toxic effect;Transgenic Mice;Translating;Work

PROJECT_TITLE: Mechanisms of diabetic amyloid formation via 2D IR spectroscopy


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Overall Proposal Project Narrative This project describes activities the California Animal Health and Food Safety Laboratory System’s Toxicology Section will undertake to support an integrated human and animal food safety network system. The Section will support the overall goals of increasing testing capability and sample capacity by committing to participate in food defense activities, by performing the analysis of animal feed products collected by the State of California’s Feed Regulatory Program, and by developing and validating methods for the analysis of hazardous chemicals in human food and animal feed.

PI_NAMEs: POPPENGA, ROBERT HOWARD (contact)

PROGRAM_OFFICER_NAME: WINTER, RONALD

PROJECT_TITLE: Leveraging Unique Capabilities and Capacities for Chemical Analyses of Diverse Food and Feed Matrices in Support of an Integrated Food Safety System


ORG_CITY: MANHATTAN

ORG_NAME: KANSAS STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: KS

PHR: Project Narrative By participating in this cooperative agreement, the Kansas Department of Agriculture Laboratory (KDAL) aims to successfully expand the testing capabilities in both Microbiology and Chemistry as well as increase sample throughput in human and animal product testing. Additionally, KDAL will continue with their existing quality system consistent with the principles and requirements of ISO/IEC 17025:2017. The standard will attest to KDAL’s competency and technical capabilities to perform tasks and support traceability of data generated. This cooperative agreement will allow for the enhancement of both human and animal food product surveillance. Moreover, it will strengthen the relationship between the laboratory and the regulatory programs. By expanding the existing surveillance program KDA aims to ensure a safer food supply for Kansas.

PI_NAMEs: HEMMERT, AMELIA  (contact)

PROJECT_TITLE: Kansas Department of Agriculture Laboratory's Implementation of a Laboratory Flexible Funding Model


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: LAS CRUCES

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: Project Narrative: Overall The NMSU Food Safety Laboratory (NMSU FSL) will work towards achieving FDA FERN objectives by participating in FERN activities such as evaluation of new methodologies, analysis of surveillance and emergency outbreak samples, and whole genome sequencing. We will work to expand our testing capabilities to include molecular detection of Cyclospora. We are committed to food safety in the Indian Nations and will partner with New Mexico Indian Health Services for sample collection. The NMSU FSL will hire a Quality Manager to work with us to achieve and maintain the ISO 17025 accreditation of our lab.

PI_NAMEs: FEDIO, WILLIS M. (contact)

PROJECT_TITLE: New Mexico State University Laboratory Flexible Funding Model (U19)


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Public Health Relevance Diabetes mellitus, one of the major leading chronic morbidities worldwide, is continually increasing with a high prevalence in the United States and throughout the world. Cardiovascular complications are mainly responsible for the high morbidity and mortality in people with diabetes. The proposed studies will significantly increase our understanding of molecular mechanisms underlying diabetes-associated coronary endothelial dysfunction and abnormal lipid transport and therefore provide the basis to develop new therapeutic strategies for the treatment of diabetes-associate cardiovascular diseases.

PI_NAMEs: JIN, ZHENG-GEN  (contact)

PROJECT_TERMS: Adipose tissue;Atherosclerosis;Blood Circulation;blood glucose regulation;Blood Vessels;Cardiac;Cardiovascular Diseases;Cardiovascular system;CD36 gene;Cells;Chronic;Coronary;Coronary Vessels;Development;Diabetes Mellitus;diabetic;Disease;DNA Repair;effective therapy;EFRAC;Endothelial Cells;endothelial dysfunction;Endothelium;energy balance;Energy Metabolism;Epidemic;epigenetic marker;Epigenetic Process;experimental study;Family;fatty acid transport;Fatty Acids;fighting;Functional disorder;gain of function;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Genome Stability;Goals;HDAC4 gene;Heart;Heart failure;Heart Hypertrophy;High Prevalence;Histone Acetylation;Histone Deacetylase;Homeostasis;Human;improved;In Vitro;in vivo;Inflammation;Knock-out;Left;Link;lipid metabolism;lipid transport;Lipids;longevity gene;loss of function;Lysine;Mediator;Metabolic;Metabolic Control;Metabolic Diseases;Metabolic syndrome;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;neglect;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Nutrient;Organ;overexpression;Pathogenesis;Pathway interactions;Patients;Persons;pharmacologic;Phenotype;Play;PPAR gamma;pre-clinical;Predisposition;preservation;Prevalence;public health relevance;Regulation;Reporting;Resistance;Risk Factors;Role;Sampling;Sirtuins;Stress;Testing;therapeutic candidate;Tissues;Transcriptional Regulation;Transgenic Mice;Transportation;treatment strategy;United States;uptake;Vascular Endothelial Cell;Vascular Endothelium;Ventricular

PROJECT_TITLE: SIRT6 and vascular endothelial homeostasis

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Recent progress in the genetics of complex diseases, including neuropsychiatric diseases, has revealed that the bulk of disease heritability is explained by the action of many common non-coding variants. We propose to develop new statistical and computational methods to infer biological function of these variants at different levels of organization. We will apply these methods to genome-scale genotype-phenotype and functional genomics datasets.

PI_NAMEs: NEALE, BENJAMIN MICHAEL;PRICE, ALKES L;SUNYAEV, SHAMIL  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Address;Alleles;Architecture;Automobile Driving;Binding;Biological;Biological Process;Biology;causal variant;cell type;Collaborations;Complex;Computer software;computerized tools;Computing Methodologies;Data;Data Set;design;Development;Disease;disease model;disease phenotype;disorder risk;Drug Targeting;Epigenetic Process;experimental study;fitness;functional genomics;Funding;Genes;Genetic;genetic architecture;genetic association;Genetic Diseases;Genetic Models;Genetic Risk;Genetic Variation;genome wide association study;genome-wide;genomic data;Genotype;Heritability;Human Resources;improved;Individual;insight;Knowledge;Link;Maintenance;Maps;Measurable;method development;Methodology;Methods;Molecular;molecular phenotype;Natural Selections;neuropsychiatric disorder;open source;Pathway interactions;Phenotype;phenotypic data;Population;Population Genetics;programs;Publications;Publishing;Quantitative Trait Loci;Rare Diseases;rare variant;Regulation;Regulatory Element;Research;RNA Splicing;Sampling;Shapes;Signal Transduction;simulation;Stable Disease;Statistical Data Interpretation;Statistical Methods;Techniques;Testing;Tissues;trait;transcription factor;transcriptomics;Twin Multiple Birth;Untranslated RNA;Variant

PROJECT_TITLE: Functional and population genetic architectures of complex disease

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Narrative Clinician scientists play a critical role in the national biomedical workforce but the number of clinician scientists is at an all time low. The overall goal of this training grant is to attract talented and interested medical students and pharmacy students into careers as clinician scientists by offering students a research fellowship that includes a mentored research project in the broad areas of infectious diseases, microbiology and immunology during the summer between first and second year of professional school. The program includes seminars, professional development, training in the responsible conduct of research, training in enhancing reproducibility of research, and the opportunity for students to present their work in oral and poster format.

PI_NAMEs: MURPHY, TIMOTHY F (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Applications Grants;Award;behavioral and social science;Biomedical Research;career;Career Choice;career development;Clinical;Communicable Diseases;Complement;Comprehensive Cancer Center;Credentialing;design;digital;Doctor of Pharmacy;Doctor of Philosophy;Education;experience;Funding;Goals;Immune System Diseases;Individual;Industry;innovation;Institution;interest;Journals;Learning;LinkedIn;Malignant Neoplasms;medical schools;Medical Students;next generation;novel therapeutics;Paper;patient oriented research;Peer Review;Pharmacists;Pharmacy Students;Physicians;Play;Positioning Attribute;Productivity;programs;Publishing;recruit;Research;research and development;Research Personnel;Role;Schools;Scientist;Students;symposium;Talents;Training;Training Programs;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;Universities;Woman;Work

PROJECT_TITLE: Training the Next Generation of Clinician Scientist

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetic Testing;Genetics;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative Breast cancer is a major cause of morbidity and mortality, being the most commonly diagnosed neoplasm (except for non-melanoma skin cancer) among women worldwide. The proposed study has translational potential given that it might lead to the development and implementation of a clinically useful prognostic and predictive test for use in breast cancer patients.

PI_NAMEs: CONDEELIS, JOHN S;ROHAN, THOMAS E (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Adjuvant Chemotherapy;Antibodies;Axillary lymph node group;Biological Assay;Blood Vessels;breast cancer metastasis;Breast Cancer Patient;Breast Cancer Risk Factor;cancer cell;case control;Case/Control Studies;cell type;Cells;Cessation of life;Characteristics;chemotherapy;Cities;Clinical;clinical prognostic;cohort;Development;Diagnosis;Disease;Disease-Free Survival;Distant Metastasis;Endothelial Cells;Epidermal Growth Factor;Epithelium;ERBB2 gene;Estrogen receptor negative;Estrogen receptor positive;Formalin;Gene Expression Profiling;Genomics;Health;Hematogenous;Human;Immunofluorescence Immunologic;Individual;intravital imaging;Label;Macrophage;Malignant Breast Neoplasm;Malignant Epithelial Cell;Mammary Neoplasms;Mediating;Mesenchymal;Methods;Modeling;Morbidity - disease rate;mortality;mortality risk;multi-photon;Mus;Neoplasm Metastasis;Neoplasms;neoplastic cell;Nested Case-Control Study;oncotype;overexpression;Paclitaxel;Paraffin Embedding;patient population;Patients;Phenotype;Positive Lymph Node;Prediction of Response to Therapy;predictive marker;predictive test;Predictive Value;Progesterone Receptors;prognostic;prognostic assays;Prognostic Marker;prognostic value;protein biomarkers;Protein Isoforms;Rattus;receptor;Recommendation;Recurrence Score;Redwood;Relapse;Risk;RNA Splicing;Rodent;Sampling;Sampling Studies;side effect;Skin Carcinoma;Structure;study population;Time;Tissue Embedding;translational potential;treatment arm;tumor;tumor microenvironment;Variant;Woman;Work

PROJECT_TITLE: TMEM, MENAcalc, and MENAINV as Prognostic and Predictive Markers for Breast Cancer Metastasis

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Nanotechnology;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The selective infiltration of immunosuppressive tumor-associated myeloid cells (TAMCs) is a hallmark of malignant brain tumors and a major hurdle to the effectiveness of anti-tumor treatments. Our work explores the use of myeloid-targeted nanoparticles to reprogram TAMC functionality as a new approach to promote anti-tumor immunity. The objective of this proposal is to reshape the immunosuppressive tumor microenvironment in a clinically relevant manner and to potentiate standard of care therapy for glioblastoma.

PI_NAMEs: ZHANG, PENG  (contact)

PROGRAM_OFFICER_NAME: PEREZ, J MANUEL

PROJECT_TERMS: Address;Adult;Agonist;Animal Model;Anti-CD47;anti-tumor immune response;antitumor effect;Antitumor Response;Brain;Brain Neoplasms;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;cancer therapy;CD47 gene;Cells;Clinical;clinical translation;clinically relevant;cytotoxic;Data;Development;Effectiveness;effectiveness evaluation;effectiveness testing;effector T cell;Experimental Animal Model;Gene Activation;Genes;genotoxicity;Glioblastoma;Human;humanized mouse;Immune;Immune response;immunogenic cell death;Immunologic Surveillance;Immunologics;Immunosuppression;Impairment;in vivo;Infiltration;Inflammatory;Inflammatory Response;Innate Immune System;interest;Interferons;Knowledge;Laboratories;lipid nanoparticle;Mainstreaming;Malignant neoplasm of brain;Malignant Neoplasms;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;nanoparticle;Nanotechnology;nanotherapeutic;Nature;neoplastic cell;Newly Diagnosed;novel strategies;Pathway interactions;Phagocytes;Phagocytosis;Phenotype;Play;Population;pre-clinical;programs;radiation effect;Radiation therapy;Research;Research Support;Resistance;response;Role;Route;Sampling;Shapes;Signal Pathway;standard of care;Stimulator of Interferon Genes;success;T cell infiltration;T cell response;T-Lymphocyte;targeted delivery;targeted treatment;temozolomide;Testing;Therapeutic;Therapeutic Effect;therapeutic nanoparticles;therapeutic target;therapy resistant;Toxic effect;treatment effect;Treatment outcome;treatment strategy;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;tumor-immune system interactions;Work

PROJECT_TITLE: Nano-therapeutics Reprogramming of Immunosuppressive Myeloid Cells Potentiate Radiotherapy for Glioblastoma

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Human Genome;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE  The human airway is composed of multiple cell types each with specialized role. Proper balance of the airway cell types, especially between differentiated luminal cells and basal progenitor cells is essential for airway maintenance and function. In this study, we will address the fundamental question of how airway progenitor versus progeny balance is established during lung formation, maintained in the adult during normal turnover, and restored following lung injury such as viral infection.

PI_NAMEs: SUN, XIN  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Address;Adult;Air;Airway Disease;airway epithelium;Alveolar;ARID1A gene;ATAC-seq;Basal Cell;biological adaptation to stress;Birth;Cell Differentiation process;cell type;Cells;Chromatin;Chronic Obstructive Pulmonary Disease;Congenital diaphragmatic hernia;Data;Death Rate;Development;Disparity;Electron Transport;endopeptidase La;Endoplasmic Reticulum;epigenomics;Epithelium;Equilibrium;Evolution;Exhibits;FGF10 gene;Genes;Growth;Health;histone demethylase;Homeostasis;Human;Individual;Influenza;influenzavirus;Injury;injury and repair;keratin 5;Knowledge;Link;Lung;lung injury;Maintenance;Measures;member;Mesenchymal;Mesenchyme;misfolded protein;Mitochondria;Mitochondrial Matrix;Mitochondrial Proteins;Modeling;Mucous body substance;Mus;mutant;Mutate;Mutation;neonatal pulmonary hypertension;novel;Nuclear;Pathway interactions;Patients;Peptide Hydrolases;Phenotype;progenitor;Proteins;Pulmonary Hypertension;pulmonary hypoplasia;Quality Control;Regulator Genes;Reserve Stem Cell;Role;seal;Serine Protease;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;stem cells;Tissues;Trachea;transcription factor;transcriptomics;tumorigenesis;Virus Diseases

PROJECT_TITLE: Balancing Airway Progenitor versus Progeny: a Pathway from Mitochondria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-R(03)]


ORG_CITY: NASHVILLE

ORG_NAME: TN STATE DEPARTMENT OF AGRICULTURE

PHR: Proposal Narrative Technical Services Laboratory (TSL) staff will support internal projects. Testing with a focus in the areas of chemistry, microbiology, and the development of new methods and special projects that expand testing will be a priority. The capacity and capabilities of Tennessee’s human and animal food Technical Services Laboratory will be enhanced.

PI_NAMEs: TRAVIS, ADAM RYAN (contact)

PROJECT_TITLE: Enhance the Capacity and Capabilities of Tennessee's Human and Animal Food Testing Laboratories in Support of an Integrated Food Safety System


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Development of patient-specific tissue models of human tumors would be transformative to cancer research and the implementation of new therapeutic modalities. We propose to develop and validate a highly advanced “cancer patient on a chip” platform, and to use this platform to study mechanisms of target specific metastasis and drug resistance of a hormone positive and triple negative invasive breast carcinoma (a prevalent cancer in women).

PI_NAMEs: VUNJAK-NOVAKOVIC, GORDANA  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Advanced Malignant Neoplasm;Algorithms;anti-cancer research;Architecture;Biological;Biomedical Engineering;Biopsy;Bioreactors;Blood;Blood Vessels;bone;Bone Tissue;Breast Adenocarcinoma;Breast Carcinoma;Cancer Biology;cancer cell;Cancer Patient;Cells;Circulation;CLIA certified;Clinical;cohort;Data;Data Engineering;Dependence;design;Development;Drug resistance;drug sensitivity;Drug Targeting;drug testing;Endothelial Cells;Engineering;exome;Extravasation;Functional disorder;Genetic Transcription;Goals;Heart;Heterogeneity;Homing;Hormones;Human;human model;Human Pathology;Image;Immune;in vitro Model;Individual;induced pluripotent stem cell;insight;Institutional Review Boards;Label;Link;Liver;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;Metastatic breast cancer;Metastatic Neoplasm to the Lung;Methodology;Methods;migration;Modality;Modeling;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel;novel therapeutics;Oncology;Operative Surgical Procedures;Organoids;Pathology;Patients;Perfusion;Pharmaceutical Preparations;Physiological;pre-clinical;preclinical study;predictive modeling;predictive panel;Primary Neoplasm;Property;Proteins;Protocols documentation;Publishing;recruit;Resistance;response;Role;scaffold;single cell analysis;single-cell RNA sequencing;Site;Slice;Specificity;Specimen;System;Systems Biology;Testing;Therapeutic;therapeutic target;Thick;Tissue Model;Tissues;transcriptome sequencing;triple-negative invasive breast carcinoma;tumor;tumor progression;Validation;Vascular Endothelium;Vascularization;Woman;Work

PROJECT_TITLE: Cancer patient on a chip

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Neurosciences;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Peptide receptor radionuclide therapy (PRRT) using 177Lu-DOTATATE (Lutathera) has recently been approved by the FDA for treatment of somatostatin receptor (SSTR) expressing gastroenteropancreatic neuroendocrine tumors (GEP-NET). However, the effect of PRRT is dependent on SSTR2 expression levels, as those with low to medium-level SSTR2 expression do not benefit from PRRT and are left with limited, marginally beneficial treatment options. Here we propose to develop and test a pulsed modulatory chemotherapy pretreatment approach to re-sensitize GEP-NETs to PRRT by upregulating SSTR2 expression through epigenetic modulators, and potentially improve the management of this difficult-to-treat patient population.

PI_NAMEs: HEIDARI, PEDRAM  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Advisory Committees;Apoptosis;Award;Bass;Beta Particle;Biodistribution;Biological Availability;cancer care;cancer cell;Cancer Center;cancer genetics;career development;Cell surface;chemotherapy;Chemotherapy-Oncologic Procedure;chromatin remodeling;Chromatin Structure;Chronic;Clinical;Clinical Trials;Combined Modality Therapy;Computational Biology;Core Facility;cytotoxic;Data;daughter cell;derepression;design;Development;Development Plans;Dose;dosimetry;Drug Combinations;Education;Educational workshop;Effectiveness;epigenetic drug;epigenetic marker;Epigenetic Process;epigenetic silencing;epigenome;experimental study;FDA approved;Fostering;Funding;gastroenteropancreatic neuroendocrine tumor;Gene Silencing;Generations;Genes;Genetic Transcription;Goals;human subject;Image;image translation;improved;improved outcome;In Vitro;in vivo;inhibitor;insight;Institution;Lead;Left;Lesion;Ligands;Malignant Neoplasms;Mediating;Mentors;Modeling;Molecular Target;mouse model;neoplastic cell;Neuroendocrine Tumors;Normal tissue morphology;novel;Organ;patient population;Patients;Peptide Receptor;Phase;Physiologic pulse;Polycomb;pre-clinical;precision medicine;Preparation;Prior Chemotherapy;programs;Promoter Regions;Proteins;Radiation Dose Unit;Radiation therapy;Radiochemistry;Radiolabeled;Radiometry;Radionuclide therapy;receptor;Receptor Up-Regulation;receptor upregulation;Regimen;Regulation;Research;Research Personnel;Resources;response;Series;side effect;somatostatin analog;Somatostatin Receptor;somatostatin receptor 2;success;systemic toxicity;Targeted Radiotherapy;Testing;theranostics;Therapeutic Effect;Therapeutic Index;Time;Training;Translating;Translations;Treatment outcome;treatment response;tumor;tumor growth;Up-Regulation;uptake;Work

PROJECT_TITLE: Enhancing the therapeutic effect of receptor radionuclide therapy in neuroendocrine tumors by somatostatin receptor upregulation

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Narrative The proposed research is relevant to public health because it focuses on discovery of novel signaling pathways that drive castration-resistant prostate cancer. These studies will establish new avenues of investigation to develop improved therapeutics to treat this deadly disease and to greatly improve patient outcome. Thus, the proposed research is relevant to NIH's mission of fostering creative discoveries and innovative research strategies for protecting and improving health and reducing the burdens associated with cancer.

PI_NAMEs: LIU, XIAOQI  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: abiraterone;Ablation;Acetylation;Affect;androgen independent prostate cancer;Androgen Receptor;Androgens;Binding;Biochemical;Bromodomain;Cancer Patient;Castration;Cell Cycle;Cell Cycle Progression;Cell Proliferation;Cells;Chemoresistance;chemotherapy;Chromatin;Clinical Research;clinically significant;Creativeness;cyclin T1;Data;design;Development;Disease;docetaxel;Docking;effective therapy;enzalutamide;Epigenetic Process;Event;Family;Fostering;genetic approach;Genetic Transcription;Genetically Engineered Mouse;genomic locus;Goals;Growth and Development function;Health;improved;in vivo;inhibitor;innovation;Investigation;loss of function mutation;Lysine;Malignant neoplasm of prostate;Malignant Neoplasms;member;Methodology;Mission;Mitosis;Mitotic;Molecular;mouse model;multicatalytic endopeptidase complex;Mutation;novel;novel strategies;Operative Surgical Procedures;Outcome;Paclitaxel;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phosphorylation;Phosphorylation Site;Phosphotransferases;PLK1 gene;prostate cancer cell;prostate cancer progression;protein degradation;Proteins;Public Health;Reader;Receptor Signaling;recruit;refractory cancer;Regulation;Research;Resistance;Resistance development;Role;Signal Pathway;Signal Transduction;Site;Specimen;standard care;success;System;Testing;Therapeutic;Therapeutic Agents;therapy resistant;Transcriptional Elongation Factors;ubiquitin-protein ligase;United States National Institutes of Health;Work;Xenograft procedure

PROJECT_TITLE: Improving chemotherapy of castration-resistant prostate cancer.

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Urologic Diseases

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE A major obstacle to achieving lasting cures for advanced malignancies is the emergence of acquired resistance to treatment, not only due to genetically resistant clones, but also through phenotypic plasticity. This proposal investigates the role of m6A RNA modifications in potentiating drug resistance in bladder cancer. It has the potential to elucidate a novel epitranscriptomic mechanism underlying the phenotypic plasticity that drives cancer progression, and to offer new therapeutic targets to short-circuit drug resistance in bladder cancer.

PI_NAMEs: HODARA, EMMANUELLE  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Adenosine;Affect;Biological Assay;Biological Markers;Biopsy Specimen;Blood specimen;cancer cell;Cancer cell line;cancer drug resistance;Cancer Patient;cancer therapy;cancer type;Candidate Disease Gene;Cell Physiology;Cells;Chromatin;Cisplatin;Clinical;CRISPR/Cas technology;Data;Deposition;differential expression;Disease Progression;DNA Methylation;DNA Sequence Alteration;Drug resistance;drug-sensitive;Environment;Epigenetic Process;epitranscriptomics;fat mass and obesity-associated protein;Flow Cytometry;Gene Expression;Genes;Genetic Transcription;High-Throughput Nucleotide Sequencing;Immunoprecipitation;In Vitro;knock-down;Knock-out;liquid biopsy;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Mediating;Mentors;Messenger RNA;Methylation;migration;Modeling;Modification;Neoadjuvant Therapy;neoplastic cell;new therapeutic target;notch protein;novel;Patients;pharmacologic;Phenotype;Physicians;Plasma Cells;Population;programs;Property;Reader;research facility;research study;Resistance;RNA;RNA methylation;Role;Sampling;Scientist;Side;Small Interfering RNA;Solid;Stains;stem-like cell;Testing;therapeutic target;tissue resource;Training;Transcript;Transcriptional Activation;transcriptome sequencing;tumor;tumor progression;tumorigenic

PROJECT_TITLE: RNA Methylation in Cancer Plasticity and Drug Resistance


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Disability Research;Hematology;Pain Research;Physical Activity;Physical Rehabilitation;Prevention;Rare Diseases;Rehabilitation;Sickle Cell Disease

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The life expectancy for individuals with sickle cell disease has improved substantially over the last 50 years; however, there are no validated methods for assessing capabilities and vulnerabilities in this aging population. The goal of this study is to evaluate the validity and reliability of the Sickle Cell Disease Functional Assessment and pilot an exercise intervention for older adults with sickle cell disease. This research will contribute by improving knowledge about management of older adults with sickle cell disease and will provide preliminary data for interventions to ameliorate functional impairment and improve longevity.

PI_NAMEs: OYEDEJI, CHARITY IBILOLA (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: acceptability and feasibility;Activities of Daily Living;Address;Adult;Aerobic;Age;age related changes;aging population;aging process;Assessment tool;career;career development;Cell Aging;Cessation of life;Clinic Visits;Clinical;Cognition;Cognitive;cohort;comorbidity;Coupled;Data;Dependence;design;Development;Development Plans;Dimensions;disability;Early identification;Educational Intervention;Elderly;Emergency department visit;Enrollment;Equilibrium;Exercise;exercise intervention;exercise program;exercise training;experience;Failure;Fatigue;Focus Groups;follow-up;Foundations;frailty;functional decline;Functional impairment;functional improvement;Funding;Future;Geriatric Assessment;Geriatrics;Goals;Health;health assessment;health care service utilization;Hematology;Hospital Departments;Hospitalization;Impaired cognition;Impairment;improved;Individual;instrumental activity of daily living;Intervention;K-Series Research Career Programs;Knowledge;Length of Stay;Life Expectancy;Longevity;low socioeconomic status;Measures;Medical;Medicine;Mentors;Mentorship;Methods;modifiable risk;mortality;Necrosis;Nutritional status;older adult;Oncology;Outcome;outcome prediction;Pain;Pain intensity;Pain interference;Participant;Patient Outcomes Assessments;Patients;Performance;Persons;Pharmaceutical Preparations;Physical assessment;physical conditioning;Physical Function;physical impairment;Physical Performance;Pilot Projects;Population;premature;prevent;primary outcome;Process;professor;programs;Property;Prospective cohort;psychologic;Psychometrics;Psychosocial Assessment and Care;Pulmonary Heart Disease;Quality of life;Randomized, Controlled Trials;Regression Analysis;Research;Research Personnel;Risk Factors;secondary outcome;Sensory;Sickle Cell;Sickle Cell Anemia;skills;Sleep;social;Social support;Stroke;success;Surveys;Testing;therapy development;Time;tool;Training Programs;Universities;Validation;Validity and Reliability;virtual;Visit;Walking;Work

PROJECT_TITLE: Sickle Cell Disease Functional Assessment Validation and Exercise Pilot Intervention


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: NEW YORK

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: NARRATIVE Monoclonal antibodies have been one of the largest classes of anti-cancer therapeutics in development over the past decade. While antibodies serve as a versatile platform for both the diagnosis and treatment of various cancers, model systems allowing adequate pre-clinical testing are limited, due, in part, to the lack of binding of human antibodies to their cognate receptors, Fcγ receptors, in mouse or macaque models. These studies aim to develop novel humanized mouse models allowing proper characterization of monoclonal antibodies destined for clinical use (e.g. pharmacokinetic, pharmacodynamic, and efficacy testing).

PI_NAMEs: BOURNAZOS, STYLIANOS  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Address;Affinity;Allogenic;Animal Model;anti-cancer therapeutic;Antibodies;antibody diagnostic;antibody engineering;Antibody Response;Antibody Therapy;antibody-dependent cell cytotoxicity;Antibody-drug conjugates;Binding;Biological;Biological Models;Biological Products;cancer cell;cancer immunotherapy;cancer therapy;Cell Surface Proteins;Cells;Chemotherapy-Oncologic Procedure;Chronic;Clinical;clinical development;clinical efficacy;clinically relevant;cytotoxic;Data;Detection;Development;Diagnosis;Diagnostic;Diagnostic Imaging;Disease;Dose;Drug Kinetics;efficacy evaluation;efficacy testing;Engineering;Epitopes;Evaluation;Exhibits;Fc domain;Fc Receptor;gene function;Generations;Genes;genetic association;genetic variant;Genetically Engineered Mouse;Half-Life;Human;human monoclonal antibodies;humanized mouse;IgG1;imaging study;Immune;Immune system;Immunocompetent;immunodeficiency;immunogenicity;Immunoglobulin Constant Region;Immunoglobulin G;immunoregulation;Immunotherapy;improved;in vivo;in vivo evaluation;in-vivo diagnostics;innovation;interest;Knock-in Mouse;Leukocytes;Macaca;Malignant Neoplasms;Methods;Modality;Modeling;Monoclonal Antibodies;mouse model;Mouse Strains;Mus;Natural Killer Cells;neonatal Fc receptor;Neoplasms;neoplastic;nonhuman primate;novel;novel therapeutics;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Pharmacodynamics;Play;Population;pre-clinical;preclinical development;preclinical evaluation;preclinical study;Preclinical Testing;Proteins;Radioimmunoconjugate;Radiolabeled;receptor;receptor expression;Role;Safety;Schedule;Sensitivity and Specificity;Series;Surface;targeted treatment;Testing;Therapeutic;Therapeutic antibodies;therapeutic evaluation;Therapeutic Monoclonal Antibodies;Toxic effect;Toxicology;transgene expression;Transgenic Mice;translational barrier;translational study;Treatment Efficacy;Treatment-related toxicity;tumor;Tumor Antigens;Tumor Immunity;Xenograft Model

PROJECT_TITLE: Novel Transgenic Mouse Models Addressing Outstanding Translational Barriers in Antibody-Based Therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-N(55)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: COLUMBIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PROJECT NARRATIVE There are a number of evidence-based strategies to address the serious public health concern of problematic college drinking; yet, the process by which colleges select and implement the strategies is unknown. This project will address this missing link by examining if and how CollegeAIM (a matrix of evidence-based strategies for college drinking developed by NIAAA) is used to by colleges to effectively identify evidence-based strategies that fit the needs of their institutions. This project will result in increased knowledge of what impedes the selection of effective interventions, and will serve as groundwork for the development of support programs to assist colleges in effectively identifying and implementing evidence-based strategies to address risky drinking.

PI_NAMEs: HELLE, ASHLEY COLLEEN (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Acceleration;addiction;Address;Administrator;Adoption;adverse outcome;Advisory Committees;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol poisoning;alcohol prevention;alcohol research;Alcohols;assault;Awareness;Behavior;career;Cessation of life;Characteristics;Clinical;college;college drinking;combat;Consultations;cost;Data;demographics;design;Development;Development Plans;Distal;effective intervention;Effectiveness;Evaluation;evidence base;experience;Exploration, Preparation, Implementation, and Sustainment;Feedback;Focus Groups;follow-up;Foundations;Future;Goals;high risk;high risk drinking;implementation process;implementation science;implementation strategy;improved;Incentives;Individual;Infrastructure;Injury;Institution;Intervention;Interview;Investigation;Investments;K-Series Research Career Programs;Knowledge;Link;member;Mentors;Methods;Missouri;National Institute on Alcohol Abuse and Alcoholism;Needs Assessment;Outcome;Perception;Positioning Attribute;Prevention;Prevention Research;Process;programs;Public Health;Reporting;Research;Research Methodology;Research Personnel;Resources;Scientist;Series;skills;Strategic Planning;Structure;Students;Substance abuse problem;substance use;Surveys;theories;tool;Training;Training Programs;Translating;Universities;university student;Update;Work

PROJECT_TITLE: The College Alcohol Intervention Matrix (College AIM): Adoption and Implementation Across College Campuses

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: TALLAHASSEE

ORG_DEPT: BIOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Narrative The Chemosensory Training Program at FSU affords pre-and post-doctoral trainees with unusually broad and deep opportunities to explore and master many research approaches to important questions about taste and smell function, whose loss involves devastating quality of life and whose central brain circuits are important in obesity, eating disorders, hypertension and other neurological disorders.

PI_NAMEs: FADOOL, DEBRA ANN (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Sensory;Training Programs

PROJECT_TITLE: Chemosensory Training Program


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA STATE DEPARTMENT OF HEALTH

ORG_STATE: IN

PHR: OVERALL PROJECT NARRATIVE PAR-20-105 In support of an integrated food safety system, the Indiana State Department of Health Laboratories (ISDHL) will enhance the capacity and capabilities of human food testing through increased sample testing in the areas of microbiology, chemistry and radiochemistry. The project will strengthen and improve FDA’s efforts to prevent foodborne illnesses and minimize exposures to hazards through ISDHL’s participation in a nationally integrated laboratory science system.

PI_NAMEs: HAGERMAN, MARY ANN (contact)

PROGRAM_OFFICER_NAME: LI, MEI-YING

PROJECT_TITLE: ISDH Laboratory Flexible Funding Model for Microbiology, Chemistry and Radiochemistry


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Many clinically used cancer therapies can trigger cellular senescence in tumor cells. Senescence is considered to be a “double-edged sword”: it is a cell autonomous tumor suppressive mechanism and has been shown to trigger potent anti-tumor immune responses, but the presence of senescent cells in the tumor microenvironment has also been shown to promote tumor progression. The studies described here will dissect the interplay between senescent cells and T cells in the tumor microenvironment and identify strategies to enhance endogenous T cell killing of senescent tumor cells.

PI_NAMEs: BRODERICK, CAROLINE  (contact)

PROJECT_TERMS: anti-cancer research;anti-tumor immune response;Biology;Bypass;cancer infiltrating T cells;cancer therapy;candidate validation;carcinogenesis;Cell Aging;Cell Communication;Cell Compartmentation;Cell Cycle Arrest;cell killing;Cell secretion;Cells;Cellular Stress;chemokine;Chronic;Clinical;CRISPR screen;cytokine;Data;DNA Damage;Funding;Gene Expression Profile;Genes;Goals;Growth;Immune;Immunologic Stimulation;Immunologic Surveillance;improved;In Vitro;in vivo;Inflammation;Inflammatory;Learning;liver cancer model;Malignant Neoplasms;Mediating;mouse model;neoplastic cell;novel;Oncogenes;Pharmaceutical Preparations;Phenotype;Predisposition;programs;Proliferating;recruit;Relapse;Research;Resistance;resistance mechanism;response;restoration;senescence;senescence associated secretory phenotype;senescent cell;success;T cell infiltration;T-Lymphocyte;Telomere Shortening;Therapeutic;therapy resistant;Training;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;Tumorigenicity;Validation

PROJECT_TITLE: Investigating the Interplay between Senescent Cells and T Cells in Cancer


NIH_SPENDING_CATS: Lung

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The University of Michigan’s Multidisciplinary Training Program in Lung Disease provides research training for M.D. and Ph.D. scientists in laboratory-based and clinical research. The purpose of this training is to produce outstanding biomedical scientists who investigate the manifestations, mechanisms, prevention, and treatment of lung disease and critical illness.

PI_NAMEs: DICKSON, ROBERT PICKETT (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Nearly 50% of Veterans suffer from chronic non-cancer pain and Veterans are 40% more likely to suffer from severe and debilitating pain than the general U.S. population. Veterans of color and women (referred to collectively as “diverse Veterans” in this CDA) are subject to unjust and risky pain treatment, including guideline-discordant opioid therapy. The VA has dedicated significant resources to evidence-based, non- pharmacological pain treatments (NPTs) to curtail the opioid epidemic, yet these treatments are not reaching diverse Veterans. Implementation mapping can be used to identify key barriers and facilitators to NPT use and map them to relevant implementation strategies and target users. Thus, the purpose of this CDA is to develop and test a tailored implementation blueprint to enhance NPT use among diverse Veterans using implementation mapping. This CDA builds on strong operational partnerships and Veteran engagement and aligns with major VA Strategic Priorities. Findings may be applied to other marginalized groups.

PI_NAMEs: JAVIER, SARAH JANE (contact)

PROJECT_TERMS: Academic Detailing;access disparities;addiction;Address;Adoption;Affect;Area;Automobile Driving;Belief;Biological;Caring;Cessation of life;Chronic;chronic pain;chronic pain management;Clinic;Color;Data;data warehouse;debilitating pain;Decision Aid;Dedications;Development;Disparity;Dose;Education;empowerment;Ethnic Origin;Evaluation;evidence base;Evidence based practice;experience;Funding;Future;future implementation;Gender;gender difference;Goals;Guidelines;health equity;Health system;Heterogeneity;Hospitalization;implementation design;implementation facilitators;implementation outcomes;implementation science;implementation strategy;Individual;Inequity;innovation;Interview;Investigator-Initiated Research;Logistic Regressions;Maps;marginalized population;Measures;men;Mentorship;Methodology;Methods;military veteran;Monitor;Needs Assessment;non-cancer chronic pain;Opioid;opioid epidemic;opioid therapy;Outcome;outreach;Pain;Pain management;patient outreach;Patient Selection;Patients;Pharmacological Treatment;Population;Protocols documentation;Provider;psychologic;Race;racial bias;Reporting;Research;Research Methodology;Research Personnel;Research Proposals;Resources;Sampling;Self Efficacy;Site;Skin;social;Source;stakeholder perspectives;stem;Surveys;Testing;Training;Treatment Protocols;uptake;Veterans;whole health;Woman;Women's Health

PROJECT_TITLE: Addressing Disparities In Pain Management

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ORG_CITY: MISSISSIPPI STATE

ORG_NAME: MISSISSIPPI STATE UNIVERSITY

ORG_STATE: MS

PHR: Narrative The Mississippi State Chemical Laboratory is a regulatory agency seeking to enhance the integrated food safety system of Mississippi in an effort to better protect the health its constituents. This will be accomplished by strengthening our collaborations with other State and Federal regulatory partners, broadening our surveillance program for human and animal food products, expanding our scope of ISO 17025 accreditation, and improving our means of data transmission to the FDA by using the National Food Safety Data Exchange.

PI_NAMEs: SPARKS, DARRELL LYNN (contact)

PROJECT_TITLE: Enhancement of Mississippi’s Capabilities in Integrated Food Safety Partnerships


ORG_CITY: LANSING

ORG_NAME: MICHIGAN STATE DEPARTMENT OF HEALTH AND HUMAN SERVICES

PHR: Project Narrative: Comprehensive surveillance activities are essential for the detection of bacterial pathogens in food products, has a tremendous impact in developing public health strategies thereby implementing remedial action for food borne illness across the State of Michigan. MDHHS BOL will therefore support FDA with food defense projects, molecular surveillance for food borne pathogens by whole genome sequencing and developing the laboratory capacity for detecting Cyclospora in food products.

PI_NAMEs: SOEHNLEN, MARTY  (contact)

PROJECT_TITLE: FDA- Laboratory Flexible Funding Model (MICROBIOLOGY)


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Epilepsy;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CAMBRIDGE

ORG_NAME: QUIVER BIOSCIENCE INC.

ORG_STATE: MA

PHR: Project Narrative Functional drug fingerprinting with all-optical electrophysiology Q-State has developed “drug fingerprinting” algorithms to identify reliable patterns in the electrophysiological properties of human stem cell derived neurons when altered by disease states and chemical matter. By fingerprinting clinically relevant compounds, we extend this technology to computationally assisted drug screening and drug repurposing, accelerating therapeutic discovery for neurological diseases. Expanding our fingerprinting assays to high-content imaging and to additional neuronal cell types will yield a richer map of the characteristics of human neurons with even greater sensitivity and scope, with the potential for broad applications in disorders of the nervous system.

PI_NAMEs: HARWOOD, BENJAMIN NATHANIEL (contact);RYAN, STEVEN JOHN

PROGRAM_OFFICER_NAME: ANDERSON, PAIGE MARIE

PROJECT_TERMS: Acceleration;Address;Algorithms;anti-epileptic agents;Area;Artificial Intelligence;Automation;Behavior;Biological;Biological Assay;Biological Sciences;Brain;Cell model;cell type;Cells;Cellular Morphology;Central Nervous System Diseases;Characteristics;Chemicals;Child;Clinical;clinical application;clinical candidate;clinical development;clinically relevant;Code;commercialization;Complex;computerized tools;Custom;Data;data streams;Databases;Defect;design;Development;Dimensions;Disease;disease model;disease phenotype;Dose;drug development;drug repurposing;Drug Screening;druggable target;efficacy clinical trial;Electrophysiology (science);Epilepsy;excitatory neuron;explainable artificial intelligence;FDA approved;Fingerprint;Fireflies;Genetic;Genetic Models;Hand;Hour;Human;Human Characteristics;human induced pluripotent stem cells;human stem cell-derived;Image;improved;in silico;In Vitro;in vivo;in vivo evaluation;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;inhibitory neuron;instrument;Learning;Libraries;Machine Learning;Manuals;Maps;Measurement;Measures;Methods;Microscope;millisecond;Modality;Modeling;Molecular Target;Morphology;mouse model;multimodality;Mutation;Nervous System Disorder;neuronal excitability;Neurons;novel;novel therapeutics;Optics;patch clamp;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Process;Production;programs;Property;Records;Reporting;Research;Resolution;Retinal blind spot;Rodent Model;Safety;screening;Series;Small Business Innovation Research Grant;Stimulus;success;Techniques;Technology;temporal measurement;Testing;Therapeutic;therapeutic candidate;Time;tool;Training;TSC2 gene;Validation;Visualization


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Nanotechnology;Orphan Drug;Rare Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE An effective therapy with reduced risks and side effects for treating venous malformations is greatly needed. We propose to develop an intravenous drug delivery system comprised of very small (“nano”) particles that will convert to a tissue-targeting state when irradiated within venous malformations. By our strategy, the accumulation of drugs at the disease site will be enhanced while off-target drug delivery will be minimized.

PI_NAMEs: CULLION, KATHLEEN  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Affect;Anatomy;Anemia;Animal Model;Animals;Area;Binding;Biodistribution;Biological;Biomedical Engineering;Blood flow;Blood Vessels;caged molecule;Cancer Biology;career;career development;Cells;Child;Combined Modality Therapy;Complex;Congenital Abnormality;Development Plans;Disease;Dose;Drug Delivery Systems;drug distribution;Drug Targeting;effective therapy;efficacy evaluation;Endothelium;Event;Exposure to;fluorophore;Formulation;FRAP1 gene;Functional impairment;Funding;Goals;Growth;Hemorrhage;Human;Immunosuppression;improved;in vivo;Incidence;Infection;inhibitor;Intravenous;Intravenous Drug Delivery Systems;irradiation;kinase inhibitor;Label;Lesion;Ligands;Light;Location;Mentors;Mentorship;Modeling;Modification;mouse model;Mus;nano;nanolabel;nanomedicine;nanoparticle;nanoparticle drug;nanoparticulate;Operative Surgical Procedures;Organ failure;Pain;particle;Particle Size;Patients;Pharmaceutical Preparations;Pharmacotherapy;Physicians;prevent;Research;Risk;Scientist;Sclerotherapy;side effect;Sirolimus;Site;skill acquisition;Smooth Muscle;Source;Surface;Surgical Management;System;systemic toxicity;targeted treatment;Technical Expertise;Techniques;Testing;Therapeutic Effect;Therapeutic Studies;thrombotic;Tissues;Training;Translational Research;Treatment Efficacy;tumor;uptake;Venous Malformation

PROJECT_TITLE: Developing Nanoparticle Drug Delivery Systems for Venous Malformations

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Infectious Diseases;Liver Disease;Microbiome;Substance Misuse

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Alcoholic liver disease affects several million people in the United States, and alcohol abuse is the most important cause of liver cirrhosis in industrialized countries. Chronic alcohol consumption is associated with changes in the composition of intestinal bacteria, but the exact mechanisms of intestinal bacterial overgrowth and dysbiosis are poorly understood. Understanding the mechanisms by which alcohol results in microbiome changes and understanding how these changes contribute to liver disease, would greatly enhance our ability to design preventive and therapeutic interventions for patients with chronic alcohol abuse.

PI_NAMEs: SCHNABL, BERND G. (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Affect;Alcohol abuse;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcoholism;Alcohols;apical membrane;Bacteria;Bacterial Translocation;Bacteriophages;Binding;Cessation of life;Chronic;chronic alcohol ingestion;Complement;Complement Receptor;Country;cytokine;Cytolysins;Data;design;Developed Countries;Development;Disease;dysbiosis;Engineering;Enterococcus faecalis;Epithelial Cells;Ethanol;Etiology;Exotoxins;Experimental Models;Exposure to;Extracellular Domain;feeding;Fucose;Functional impairment;gain of function;Galactose;Glycocalyx;Glycoproteins;Growth;gut colonization;gut microbiota;Hepatic;Hepatocyte;humanized mouse;immunoglobulin receptor;improved;Inflammatory;Innate Immune Response;innovation;insight;Interleukin-1 beta;interleukin-22;Intervention;intestinal epithelium;Intestinal Mucosa;Intestinal permeability;Intestines;Kupffer Cells;Laboratories;Liver;Liver Cirrhosis;Liver diseases;liver inflammation;liver injury;loss of function;Mediating;Medical;microbiome;microbiome research;microbiota;mortality;mouse model;Mucous Membrane;Mus;Nature;novel;pathogen;Patients;Pattern;Persons;Phagocytes;Phagocytosis;pharmacologic;Pharmacological Treatment;Pre-Clinical Model;prebiotics;prevent;preventive intervention;Publications;receptor;Recombinants;Research;resistance factors;Role;Secretor blood group alpha-2-fucosyltransferase;Severity of illness;Surface;System;Testing;Therapeutic Intervention;Toxin;United States

PROJECT_TITLE: Microbiome and Intestinal Innate Immune Response in Alcoholic Liver Disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ORG_CITY: GAINESVILLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: The three principal investigators affiliated with this proposal have pioneered studies uncovering a potential role for the endocrine and exocrine pancreas in type 1 diabetes (T1D), including: 1) characterizing T1D development in organ donor pancreata (Atkinson); 2) the use of imaging mass cytometry (IMC) for simultaneous in situ detection of over 40 validated protein and mRNA molecules, now with 120 validated targets in human pancreas tissue (Bodenmiller); and 3) utilizing pancreas tissue slice culture to assess islet and acinar cell function by live cellular imaging of Ca2+ signaling, as well as endocrine hormone and exocrine enzyme secretion (Speier). Herein, we propose to apply these techniques, along with single cell transcriptomic and epigenomic profiling, in fresh organ donor pancreata to address the hypothesis that altered β-cell status and the surrounding microenvironment contribute to impaired insulin processing, altered islet and exocrine cell function, and insulitis during T1D progression. We expect these studies to link cellular dysfunction, phenotype, and organization in the pre-T1D and T1D conditions, thereby identifying an integrated T1D signature at the islet↔immune↔exocrine interface, providing novel insights into disease mechanisms and therapeutic interventions.

PI_NAMEs: ATKINSON, MARK A. (contact);BODENMILLER, BERND ;SPEIER, STEPHAN

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: 3-Dimensional;Acinar Cell;Address;Age;Agonist;Alpha Cell;Amylases;Antibodies;antibody conjugate;Area;Arginine;Autoantibodies;Autoimmunity;Autophagocytosis;Beta Cell;Biological Assay;Blood Vessels;Carbachol;Caring;Cell Death;Cell Physiology;cell type;Cells;Cellular Stress;Characteristics;Cholecystokinin;Computer Analysis;cytokine;Cytometry;Data;Defect;Detection;Deterioration;Development;Diabetes Mellitus;diabetes pathogenesis;diabetogenic;Disease;Disease Progression;Dissociation;Endocrine;endoplasmic reticulum stress;Enhancers;Environment;Enzymes;Epigenetic Process;epigenomic profiling;epigenomics;Epitopes;exenatide;Exocrine pancreas;experience;Extravasation;Failure;Functional disorder;GLP-I receptor;Glucagon;Glucose;Histology;Hormones;Human;Image;Imatinib;Immune;immune cell infiltrate;Impairment;In Situ;indexing;Individual;Infiltration;Inflammation;Inflammatory;innovation;insight;Insulin;Insulin-Dependent Diabetes Mellitus;insulitis;Intervention;islet;Islet Cell;islet cell antibody;Islets of Langerhans;Laboratories;Link;Lipase;live cell imaging;Location;Lymphatic;Maps;Measures;Messenger RNA;Metabolic Pathway;Methodology;Molecular;Molecular Profiling;Natural History;non-diabetic;novel;Oligonucleotides;Organ;Organ Donor;Pancreas;Pathology;Pathway interactions;Persons;Phenotype;Physiological;prevent;Principal Investigator;Production;programs;Proinsulin;Proteins;Proteomics;reconstruction;Recovery;Residencies;Resolution;response;Role;senescence;Series;Serum;Signal Pathway;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Slice;Stimulus;Structure of beta Cell of islet;System;targeted imaging;Techniques;Testing;therapeutic candidate;Therapeutic Intervention;therapeutic target;Time;Tissue-Specific Gene Expression;Tissues;tool;trafficking;transcriptome;transcriptomics;Transplantation;Trypsin;Trypsinogen;Tyrosine Kinase Inhibitor

PROJECT_TITLE: Co-registration of Cell Organization, Phenotype and Function in the Human Pancreas During Type 1 Diabetes

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;Diabetes;Heart Disease;Prevention

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This project will investigate the pathways linking diabetes to heart failure and its subtypes, using innovative epidemiological, plasma proteomic, and cardiac PET imaging approaches. This work will inform efforts to predict and prevent heart failure among individuals with diabetes.

PI_NAMEs: ECHOUFFO TCHEUGUI, JUSTIN BASILE (contact)

PROJECT_TERMS: Acceleration;Adult;Animals;aptamer;Atherosclerosis Risk in Communities;Biological Markers;Biostatistical Methods;Cardiac;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;career;Characteristics;Circulation;Clinic;Clinical;Clinical Research;cohort;Communities;Competence;Complement;Coronary;Coronary Arteriosclerosis;Data;Data Collection;design;Development;Diabetes Mellitus;diabetic;Diagnosis;Doctor of Philosophy;Early Diagnosis;EFRAC;Endocrinology;endothelial dysfunction;Endothelin-1;Endothelium;Epidemiologic Methods;Epidemiology;experience;Five-Year Plans;follow-up;Functional disorder;Funding;Future;Goals;Grant;Heart failure;heart imaging;Hospitals;Human;Hyperglycemia;Image;imaging approach;Imaging Techniques;improved;Incidence;Individual;Inflammation;Inflammatory;Injury;innovation;Intervention;Investigation;Link;Measures;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;metabolic imaging;Metabolism;Microvascular Dysfunction;Molecular;Myocardial;Myocardial dysfunction;myocardial injury;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;older adult;Participant;Pathogenicity;Pathology;Pathway interactions;Patient Recruitments;Patients;Performance;Phenotype;Physicians;Plasma;Plasminogen Activator Inhibitor 1;Play;Positioning Attribute;Positron-Emission Tomography;Prediabetes syndrome;preservation;prevent;Prevention;Preventive;professor;programs;Prospective cohort;Proteins;Proteomics;recruit;Research;Research Design;Research Proposals;Risk;risk prediction;Sampling;Scientist;Series;skill acquisition;skills;Statistical Models;Stress;Structure;System;Techniques;Training;United States National Institutes of Health;Universities;Ventricular Dysfunction;Ventricular Remodeling;Work

PROJECT_TITLE: Establishing the Pathways Between Diabetes and Cardiac Dysfunction: Epidemiology, Biomarkers, and Imaging

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ORG_CITY: LINCOLN

ORG_NAME: NEBRASKA ST DEPARTMENT OF AGRICULTURE

ORG_STATE: NE

PHR: Nebraska Department of Agriculture Laboratory, PAR-20-105 Project Narrative The Nebraska Department of Agriculture (NDA) Laboratory is applying for eight project tracks under the Laboratory Flexible Funding Model to enhance human and animal food testing capacity and expand our testing capabilities. In this new era of food safety, Nebraska will continue to collaborate with FDA and state partners to strengthen our national network of laboratories. Together we will accelerate the traceability of food contamination events, respond to emerging food safety issues more efficiently, and achieve an Integrated Food Safety System.

PI_NAMEs: PEARSON, ERIK  (contact)

PROJECT_TITLE: Enhance Capacity and Capability of State Human and Animal Food Testing - Nebraska Department of Agriculture


ORG_CITY: FRANKFORT

ORG_NAME: KY ST CABINET/HEALTH/FAMILY SERVICES

PHR: BETH JOHNSON 4/2/20 Kentucky DPH Environmental Micro and Chemistry Food Surveillance and Protection Project Narrative: PAR -20-15 3/25/20 This funding is critical in order to provide support for the Food Safety Branch/KY State MFRPS and the conformance of Standard 10. This proposal will allow DLS to increase and enhance the analytical capacity and testing diversity, in both environmental microbiology and chemistry that can be provided to the Commonwealth of KY, as we are the only Public Health Laboratory in the State of Kentucky.

PI_NAMEs: JOHNSON, BETH D (contact)

PROJECT_TITLE: Kentucky DPH Environmental Micro and Chemistry Food Surveillance and Protection.