NIH_SPENDING_CATS: Genetics;Microbiome;Neurosciences

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Histone monoaminylation (i.e., H3 serotonylation and dopaminylation), in which the neurotransmitters are modification donors, is a newly identified epigenetic marker that plays an important role in regulating neuronal transcription. By applying chemical biology approaches, we recently discovered that the dynamics of histone monoaminylation (including installation, removal, and replacement) are regulated by a single enzyme, transglutaminase 2 (TGM2), and thereafter identified an unreported epigenetic marker (i.e., H3 histaminylation) that promotes neural rhythmicity. Our proposed research program will provide a chemical biology toolbox for investigating histone monoaminylation and elucidate its impacts on chromatin structure and function, which will build new pathophysiological connections between neuroscience, epigenetics, and psychology.

PI_NAMEs: ZHENG, QINGFEI  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Development of a Chemical Biology Toolbox to Investigate Histone Monoaminylation


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Diabetes;Genetics;Human Genome;Kidney Disease;Prevention

ORG_CITY: CAMBRIDGE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: NARRATIVE Kidney disease is a common and devastating complication of diabetes, and represents a major public health problem worldwide. We have discovered inherited factors that influence risk of this complication in type 1 diabetes; in this cycle we propose to expand our approach to type 2 diabetes, increasing sample size seven-fold to augment the opportunities for genetic discovery. In addition, by combining and integrating data from several complementary approaches (genomics, epigenetics, gene expression analysis and functional studies in model systems) we hope to identify genes and biological processes that impact the development of diabetic kidney disease, and may help guide the development of improved treatments and preventive measures.

PI_NAMEs: FLOREZ, JOSE CARLOS;HIRSCHHORN, JOEL N (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Address;Affect;Amputation;Animals;Award;Biological;Biological Assay;Biological Markers;Biological Models;Biological Process;Biology;Blindness;Blood;Cell model;Chronic Kidney Failure;clinical predictors;Code;cohort;Collaborations;Collagen Type IV;Complement;Complex;Complication;Complications of Diabetes Mellitus;computerized tools;Data;data integration;Data Set;Development;Diabetes Mellitus;diabetic;Diabetic Angiopathies;Diabetic Nephropathy;DNA Sequence;End stage renal failure;Epigenetic Process;epigenomics;Etiology;exome sequencing;Experimental Models;Frequencies;functional genomics;Funding Mechanisms;Gene Expression Profiling;Genes;Genetic;genetic analysis;genetic association;Genetic Determinism;Genetic Markers;genetic risk factor;genome sequencing;genome wide association study;genome-wide;Genomics;glomerular basement membrane;glycemic control;Grant;Heart Diseases;Heritability;Heterogeneity;Human;human data;human stem cell-derived;Hyperglycemia;improved;in vivo Model;Individual;Infrastructure;Inherited;insight;Insulin-Dependent Diabetes Mellitus;Interdisciplinary Study;International;Ireland;Kidney;kidney biopsy;kidney cell;Kidney Diseases;Knowledge;Longitudinal cohort;Mediating;Mendelian randomization;Meta-Analysis;Metabolic Diseases;Methylation;Michigan;Microvascular Dysfunction;Missense Mutation;model organism;Modeling;Molecular;molecular targeted therapies;Non-Insulin-Dependent Diabetes Mellitus;Northern Ireland;novel;Organ;Organoids;Participant;Pathogenesis;Pathway interactions;Patients;Pennsylvania;peripheral blood;Phenotype;potential biomarker;predictive tools;Prevention;Prevention strategy;Preventive measure;protein structure;Proteins;Public Health;rare variant;Regulatory Element;Research;Resources;Risk;Risk Factors;Sample Size;Sampling;Severities;Signal Transduction;statistics;Stroke;success;synergism;Transcript;type I and type II diabetes;Universities;Untranslated RNA;Validation;Variant;whole genome;Work;Zebrafish

PROJECT_TITLE: A functional genomics pipeline for genetic discovery in diabetic kidney disease

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: FRANKFORT

ORG_NAME: KENTUCKY STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: KY

PHR: KDA Produce Safety Program  Project Narrative The relevance of this project to public health is to minimize the risk of serious adverse health consequences or death from consumption of contaminated produce through the application of science-based minimum standards for the safe growing, harvesting, packing, and holding of produce raw agricultural commodities grown for human consumption as contained in 21 CFR Part 112. This project will allow KDA to continue to build a robust, verified farm inventory which will be shared with our federal partners. Through both the application of a robust Education/Outreach and Inspection/Compliance/Enforcement program, as promulgated in Kentucky’s Produce Safety Statute (KRS 260.765 to 260.772.) and Produce Safety Administrative Regulation (302 KAR 60:010), the KDA Produce Safety Program will ensure that both covered and exempt growers of covered produce understand and, where applicable, apply the regulatory mandates and produce safety best practices to reduce produce- related illnesses and ensure a safe, wholesome food supply for the Commonwealth and abroad.

PI_NAMEs: HAMILTON, DORIS  (contact)

PROGRAM_OFFICER_NAME: VARGO, ADRIANNA

PROJECT_TITLE: Path C The FDA's Cooperative Agreement Program for States and Territories to Implement a National Produce Safety Program (U2F) Clinical Trials Not Allowed


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: BURLINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE Dengue viruses has been identified in 128 countries, exposing nearly 4 billion people, over half the world's population, to risk of dengue disease. There is an urgent need to make safe and effective dengue vaccines available, particularly in areas where dengue is endemic. This study will use a specialized vaccine-challenge trial design to test the safety and efficacy of the NIH's lead dengue vaccine candidate, TV005, in dengue- endemic Bangladesh as the critical next step in product development of this promising vaccine.

PI_NAMEs: KIRKPATRICK, BETH DIANE (contact)

PROGRAM_OFFICER_NAME: FLORESE, RUTH HUAB

PROJECT_TERMS: Acceleration;Achievement;Address;Adult;Adverse event;Age;Arboviruses;Area;Asia;Attenuated;Attenuated Vaccines;Bangladesh;CD8-Positive T-Lymphocytes;Child;Clinical;Clinical Markers;Country;cytokine;Data;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Dengvaxia;design;Development;Disease;Dose;efficacy trial;Enrollment;Evaluation;Frequencies;Future;Hospitalization;Human;human morbidity;Immune;Immune response;Immunity;Immunologic Markers;Immunologics;Individual;Infection;innovation;Inpatients;Latin America;Lead;Licensing;Licensure;Measures;Memory B-Lymphocyte;Modeling;National Institute of Allergy and Infectious Disease;neutralizing antibody;Persons;Phase;phase 2 testing;Phenotype;Placebos;Polymerase Chain Reaction;Population;post-market;predictive modeling;prevent;Probability;product development;protective efficacy;Public Health;Randomized;Recombinants;Reporting;Reproducibility;Research Design;response;Reverse Transcription;Risk;Safety;safety assessment;safety testing;Serotyping;Serum;Signal Transduction;Statistical Models;Testing;transmission process;trial design;United States National Institutes of Health;Vaccination;vaccine access;vaccine candidate;vaccine development;vaccine efficacy;vaccine safety;vaccine trial;Vaccinee;Vaccines;Viremia;Virus;volunteer

PROJECT_TITLE: A Phase II Evaluation of the Safety and Protective Efficacy of the Live Attenuated Tetravalent Dengue Vaccine TetraVax-DV with Challenge by the Recombinant DENV-2 Virus in a Dengue Endemic Population


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Prevention;Substance Misuse;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Women who use drugs in Tanzania shoulder a disproportionate burden of the HIV epidemic in Tanzania. Mental disorders, including depression, anxiety, and post-traumatic stress disorder, are high among women who use drugs and are known barriers to HIV prevention, including pre-exposure prophylaxis for HIV (PrEP). The study will adapt and pilot motivational interviewing for PrEP engagement and the Common Elements Treatment Approach, a transdiagnostic psychotherapy intervention for the treatment a range of mood and anxiety disorders, for delivery by paraprofessionals in Dar es Salaam, Tanzania, to optimize PrEP engagement among women who use drugs.

PI_NAMEs: SALEEM, HANEEFA TASLEEM (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Address;Adherence;Adopted;Adult;AIDS prevention;Anxiety;Anxiety Disorders;anxiety symptoms;arm;associated symptom;Behavior;Cognitive Therapy;community advisory board;Community Health Aides;Dependence;depressive symptoms;Diagnostic;Drug usage;Drug user;Economics;Educational Intervention;effectiveness-implementation RCT;Elements;Epidemic;Evidence based intervention;experience;Feasibility Studies;feasibility trial;Focus Groups;Funding;Goals;Health;health training;Heroin;High Prevalence;high risk population;HIV;housing instability;Hybrids;improved;inattention;Incidence;innovation;Intervention;intervention delivery;intervention effect;Interview;low and middle-income countries;male;men;Mental Depression;Mental disorders;Mental Health;Modeling;Mood Disorders;Motivation;motivational enhancement therapy;Needs Assessment;novel;opioid use;peer;Phase;Pilot Projects;pilot test;Population;post-traumatic stress;Post-Traumatic Stress Disorders;pre-exposure prophylaxis;Prevalence;Prevention strategy;primary outcome;Professional counselor;Psychotherapy;Randomized, Controlled Trials;Research;secondary outcome;Services;sex;sexual violence;Shoulder;Specialist;Structure;substance use;Substance Use Disorder;Supervision;Surveys;syndemic;Tanzania;Testing;Treatment Efficacy;Treatment outcome;uptake;Vulnerable Populations;Woman;women's prevention;Work

PROJECT_TITLE: Optimizing PrEP Engagement Among Women Who Use Drugs in Tanzania

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: Princeton

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE For productive infection, human viruses control the function of organelles by rewiring the membrane contact sites (MCS) that facilitate dynamic organelle-organelle networks, which we uncovered occurs across viral infections. We further discovered a new, infection-induced mitochondria-ER encapsulation, which we propose addresses the paradox of how certain viruses promote cellular respiration despite inducing mitochondrial fragmentation. This proposal will establish how mitochondria-ER encapsulations inhibit host responses and facilitate metabolic reprogramming to meet the energetic needs of virion production, of which the molecular determinants have broad implications for viral pathogenesis and metabolic disorders.

PI_NAMEs: CRISTEA, ILEANA M. (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acetylation;Activities of Daily Living;Address;Area;betacoronavirus;Binding;Bioenergetics;Biogenesis;Biological Assay;Biological Process;Cell Respiration;Cell Survival;Cells;Coupled;Crista ampullaris;Cryo-electron tomography;Cues;Cytomegalovirus;Cytomegalovirus Infections;Daughter;Depressed mood;Electron Microscopy;Electron Transport;Encapsulated;Event;genetic manipulation;Herpesviridae;Hour;Human;Hybrids;Image;Immune response;In Situ;Infection;Influenza;Inner mitochondrial membrane;interdisciplinary approach;Lamins;Ligation;light microscopy;Link;lipidomics;Lipids;live cell microscopy;Lysosomes;Mass Spectrum Analysis;Membrane;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Microscopy;Mitochondria;mitochondrial membrane;Modeling;Molecular;molecular dynamics;Molecular Virology;Morphogenesis;Nuclear;Organelles;Outcome;Output;Oxidative Phosphorylation;Oxygen Consumption;Pathology;Pathway interactions;Peripheral;peroxisome;Population;Production;Productivity;Proteins;Proteomics;recruit;Regulation;release of sequestered calcium ion into cytoplasm;Reporting;Research;Respiration;respiratory;Role;Shapes;Signal Transduction;Site;spatiotemporal;Structure;Structure-Activity Relationship;superresolution microscopy;ultra high resolution;Viral;Viral Pathogenesis;Viral Physiology;Viral Proteins;Virion;virology;Virus;Virus Diseases;Work

PROJECT_TITLE: Dynamic virus-driven remodeling of ER-mitochondria contacts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-S(02)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: EAST LANSING

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative The goal is to revolutionize physiological measurement of vocal fold vibration and establish linkage with perceptual measurement of voice quality in connected speech. This research will advance scientific knowledge of the effects of coarticulation on phonatory onset/offset, and peri-phonatory vibration and establish their relations to perceived voice quality. Computational modeling of voice quality perception and machine learning will harness the large data sets associated with high-speed videoendoscopic imaging in connected speech to identify physical measures that ultimately may lead to better assessment and management of voice disorders.

PI_NAMEs: DELIYSKI, DIMITAR D (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TITLE: Towards Precision Assessment of Dysphonic Speech: From Vocal Fold Physiology to Perception

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: Arlington

ORG_NAME: ISA ASSOCIATES, INC.

ORG_STATE: VA

PHR: PROJECT NARRATIVE This project aims to develop a mobile phone-based program designed to eliminate colorectal cancer disparities among medically underserved African American men. The proposed intervention is designed for use in Federally Qualified Health Centers and other clinics serving underinsured or uninsured patients. It can be deployed in the community via outreach workers or with primary care patients identified as non-compliant with colorectal cancer screening.

PI_NAMEs: LEAF, SAMANTHA L. (contact)

PROGRAM_OFFICER_NAME: ZHAO, MING

PROJECT_TERMS: Address;Adherence;Adoption;Adult;African American;African American population;Age;Algorithms;Behavior;Belief;Benchmarking;black men;Black Populations;Black race;Breast Cancer Detection;Cancer Etiology;cancer health disparity;cancer invasiveness;care providers;Caring;Cellular Phone;Cervical Cancer Screening;Cessation of life;Clinic;Collaborations;Colonoscopy;Colorectal Cancer;colorectal cancer screening;Communities;community based care;Complex;cost;Counseling;Death Rate;design;Development;Diagnosis;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Enrollment;Exclusion;Family;Feces;Federally Qualified Health Center;follow-up;Gender;group intervention;Health;health assessment;health belief;health care settings;health disparity;high school degree;Human Resources;Imagery;improved;Incidence;Individual;Institution;Instruction;Intervention;Knowledge;Language;Link;low health literacy;low socioeconomic status;male;Malignant Neoplasms;Measures;Medical;medically underserved;men;Meta-Analysis;mHealth;mhealth interventions;Modeling;mortality;non-compliance;Online Systems;outreach;Participant;patient-level barriers;Patients;peer;personalized intervention;Persons;Phase;Positioning Attribute;Poverty;Precancerous Polyp;preference;prevent;Preventive service;primary care patient;primary care setting;programs;prototype;Provider;Public Health;Race;racial disparity;racism;Randomized;Recommendation;Recording of previous events;Reporting;Research;Resources;screening;Screening for cancer;screening guidelines;Services;Site;skill acquisition;Socioeconomic Status;Survival Rate;systematic review;telephone based;Testing;Text;Text Messaging;text messaging intervention;therapy design;tool;Underinsured;Underserved Population;Uninsured;United States;uptake;usability

PROJECT_TITLE: Reducing Colorectal Cancer Health Disparities: An mHealth Intervention to Improve Screening among African American Men


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention;Vector-Borne Diseases

ORG_CITY: ATHENS

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: NARRATIVE Recent advances in scientific research have allowed more in-depth data collection from epidemiological studies of infectious diseases, but predicting outcomes of interest with available data sources in a timely manner remains a grand challenge. This proposal aims to refine predictive models for several neglected and emerging infectious diseases by incorporating new mechanisms better handling missing data and time- dependent information. The methodological development and prediction tools resulted from this project will have a broader long-term impact beyond the scope of the infectious diseases covered in the current proposal.

PI_NAMEs: SHEN, YE  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Adopted;climate data;Collection;Communicable Diseases;computerized data processing;cost effective;COVID-19;Data;Data Analyses;Data Collection;data handling;Data Sources;Databases;Development;disorder control;disorder prevention;Emerging Communicable Diseases;Epidemic;epidemiologic data;epidemiology study;Foundations;Future;Human;Infectious Disease Epidemiology;interest;Intervention;Learning;machine learning method;Measures;method development;Methodology;Modeling;neglect;outcome prediction;Performance;Play;prediction algorithm;predictive modeling;predictive tools;prognostic;Research;Research Activity;Risk;Role;Schistosomiasis;seasonal influenza;statistical and machine learning;Time;Update;Vaccines;Validation;wearable data

PROJECT_TITLE: Refining Predictive Models for Neglected and Emerging Infectious Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The overall goal of this project is to apply genomic discoveries toward prediction of clinical outcomes in congenital heart disease. The proposal encompasses innovative concepts and methodologies that will advance the field of congenital heart disease in a very practical manner.

PI_NAMEs: TRISTANI-FIROUZI, MARTIN  (contact);YANDELL, MARK DOUGLAS;YOST, H. JOSEPH

PROGRAM_OFFICER_NAME: SCHWARTZ, BRYANNA NICOLE

PROJECT_TERMS: Artificial Intelligence;Artificial Intelligence platform;Bayesian Network;Bioinformatics;Childhood;Clinical;Clinical and Translational Science Awards;clinical care;Clinical Data;clinical database;Clinical Research;Collaborations;comorbidity;Complex;congenital heart abnormality;Data;data infrastructure;data resource;Data Set;Dependence;design;Diagnostic;Disease Outcome;Electronic Health Record;empowerment;Fostering;Foundations;Gender;gene function;Genes;genomic data;Genomics;Genotype;Goals;Heart;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;Internet;Investments;Knowledge;member;Methodology;Modeling;Multicenter Studies;National Heart, Lung, and Blood Institute;Network-based;next generation;novel;Online Systems;Outcome;outcome prediction;Outcomes Research;Pathway interactions;patient oriented;Patients;Pediatric Cardiac Genomics Consortium;Pediatric cardiology;Phenotype;predict clinical outcome;programs;Readability;Recording of previous events;relational database;repository;Research;Research Personnel;Resources;Risk Factors;Scientist;Site;skills;Societies;Standard Model;surgery outcome;Testing;Therapeutic;Thoracic Surgical Procedures;tool;Training;Translating;Utah;Vision;Visit;web platform;Work

PROJECT_TITLE: Bridging the Gap between Genomics and Clinical Outcomes in CHD


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Decision making based on reinforcement learning (RL) is a fundamental process of animal behavior that is impaired in psychiatric disorders such as schizophrenia and ADHD. We propose to study neural circuit mechanisms mediating RL-based decision making using cutting-edge circuit dissection tools in mice.

PI_NAMEs: KOMIYAMA, TAKAKI  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Affect;Animal Behavior;Animals;Architecture;Area;Artificial Intelligence;Attention deficit hyperactivity disorder;Behavior;Behavioral;Brain;Calcium;Chronic;Clinical;Code;Cognition Disorders;Cognitive;Complex;Data Set;Decision Making;deep reinforcement learning;design;Development;Diagnosis;Dissection;Dopamine;Dorsal;experimental study;flexibility;Human;Image;Impaired cognition;Impairment;insight;Learning;Learning Disorders;learning network;learning strategy;lens;Maintenance;Medial;Mediating;Mental disorders;Modeling;mouse genetics;Mus;neural;neural circuit;neural correlate;neuroimaging;neuromechanism;Neurons;Neurosciences;novel;optogenetics;Pattern;Performance;Play;Population;Prefrontal Cortex;Presynaptic Terminals;Process;Psychological reinforcement;Psychology;Research;Resolution;Resources;Role;Schizophrenia;serial imaging;Signal Transduction;Silver;Synaptic plasticity;Technology;Testing;theories;therapy development;tool;Training;two-photon;Update;Ventral Tegmental Area;Vertebral column;Work

PROJECT_TITLE: Cortical plasticity during reinforcement learning

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric;Social Determinants of Health

ORG_CITY: ARLINGTON

ORG_NAME: WETA TV 26

PHR: Project Narrative This project will equip teens with the skills to produce high quality, compelling health video content for the PBS NewsHour, local PBS stations and Student Reporting Labs (SRL) audiences, which will increase youth engagement with health sciences, including exposure to health science careers, through project-based learning resources that leverage storytelling and journalistic integrity. Building from previous SEPA research findings that showed success in a select number of journalism classes that produced health stories, SRL is ready to take our programming to the next level by working with STEM program leaders, educators and teens to create peer-to-peer STEM health reporting and educational resources supporting health literacy for a wide range of classrooms and STEM programs, focusing intentionally on strategies to include groups under-represented in STEM fields. This project will ultimately support hundreds of STEM educators and programs with the tools to communicate the value of health science, rebuild trust and introduce teens from diverse backgrounds to pathways for meaningful, lifelong engagement with health science issues, both as informed citizens able to combat misinformation and as the next generation of health professionals, in careers and contexts unimaginable today.

PI_NAMEs: CLAPMAN, LEAH  (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: Awareness;career;career awareness;Career Choice;combat;Communication;Communities;Continuing Education;demographics;Development;digital;Discipline;E-learning;Ecosystem;education resources;educational atmosphere;Educational Curriculum;Effectiveness;Elements;empowerment;Environmental Health;Ethics;Evaluation;evidence base;Exposure to;flexibility;Foundations;General Population;Grant;Health;health literacy;Health Personnel;Health Professional;Health Sciences;high school;improved;instrument;interest;intergenerational;Journalism;Learning;literacy;Maps;Measures;Mental Health;Methods;Misinformation;news;next generation;pandemic disease;Participant;Pathway interactions;peer;peer learning;Persons;programs;project-based learning;Public Health;real world application;Reporting;Research;Research Personnel;Resources;Science;skills;social consciousness;social media;Source;STEM field;STEM program;student participation;student retention;Students;success;teacher;Teenagers;tool;Trust;Underrepresented Populations;Update;Work;Youth

PROJECT_TITLE: PBS NewsHour STEM StoryMaker: Project-based learning for youth health literacy and biomedical career awareness through journalism and storytelling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE (RELEVANCE) Perception, cognition and action require the coordination of neurons spanning the entire brain, including the cortex and subcortical regions, and numerous brain disorders involve some form of impairment of that communication and coordination. To better diagnose and treat brain disorders, it is crucial to understand the basic mechanisms by which neural circuits interact across the brain and how those interactions give rise to cognitive processes and behavior. The proposed research investigates how cortical and subcortical circuits give rise to the state of arousal, and how intervention in those circuits can modulate that internal state and influence behavior.

PI_NAMEs: SMITH, MATTHEW A (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Affect;Area;Arousal;Attention;Behavior;Behavior Control;behavior influence;Behavioral;Bilateral;Blood;Blood Vessels;Brain;Brain Diseases;Brain region;Cerebrum;Clinical;Cognition;Cognitive;cognitive ability;cognitive process;Communication impairment;computer framework;design;Diagnosis;Diffuse;dimension reduction;Dimensions;Disease;Distant;electrical microstimulation;Electroencephalography;Electrophysiology (science);Exhibits;experimental study;functional magnetic resonance imaging/electroencephalography;high dimensionality;Hour;indexing;Individual;insight;Intervention;Link;locus ceruleus structure;Magnetism;Measurable;Measurement;Measures;Nervous System Disorder;neural;neural circuit;Neuromodulator;neuronal circuitry;Neurons;neuroregulation;Neurosciences;neurovascular;nonhuman primate;Norepinephrine;Outcomes Research;Pattern;Perception;Performance;pharmacologic;Pharmacological Treatment;Play;Population;Prefrontal Cortex;Pupil;Research;Role;Scalp structure;Shapes;Signal Transduction;Structure;System;Techniques;temporal measurement;Testing;Time;Utah;Waxes;Work

PROJECT_TITLE: Slow time scale fluctuations in neurons and behavior


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: PROJECT NARRATIVE  The goal of this research is to evaluate whether repeated spaced retrieval practice promotes word learning to a greater extent than repeated study without retrieval prompts in children with autism spectrum disorders (ASD). This study will assess multiple aspects of word learning including word form (phonological information for each novel word), word meaning (semantic information associated with each novel word), and generalization of newly taught words. This comprehensive assessment of word learning is particularly important for the ASD population because they have deficits in word learning, with particular challenges with semantic learning and generalization; therefore, identification of effective teaching strategies (i.e., retrieval practice) will have important implications for theories of language learning in children with ASD and will yield meaningful clinical/educational implications.

PI_NAMEs: HAEBIG, EILEEN KATHERINE (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 8 year old;Address;Adult;autism spectrum disorder;autism symptoms;autistic children;Categories;Cattle;Child;Clinical;clinical practice;Cognitive;cognitive control;Cognitive Science;Color;Comprehension;Development;Education;Educational process of instructing;Evidence based intervention;flexibility;functional independence;Future;Goals;Image;improved;Individual;infancy;Knowledge;Label;Language;Language Development;Language Development Disorders;language impairment;Learning;Learning Difficulty;lexical;Literature;Memory;Modality;Names;novel;Performance;Phase;phonology;Population;Positioning Attribute;Production;psychologic;Quality of life;Recommendation;Research;response;Retrieval;Schedule;Semantics;Severities;skills;sound;Stimulus;success;Techniques;Testing;theories;Time;traditional therapy;Vocabulary;word learning;Work

PROJECT_TITLE: Retrieval-Based Word Learning in Autism Spectrum Disorder

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Nanotechnology;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative This project will develop an ultrasound-mediated sensitizing pretreatment to improve the outcomes of radiation therapy of solid tumors. Specifically, we will use sensitizing nanobubbles excited by ultrasound to locally prime tumors before external beam radiotherapy, reducing the radiation dose and leading to compete tumor regression. We will test the approach in treatment of prostate cancer.

PI_NAMEs: CZARNOTA, GREGORY JAN;EXNER, AGATA A (contact);KOLIOS, MICHAEL

PROGRAM_OFFICER_NAME: GRODZINSKI, PIOTR

PROJECT_TERMS: Acoustic Stimulation;Acoustics;Acute;Address;Aftercare;Animals;Antineoplastic Protocols;Biodistribution;Biological Markers;Biomedical Engineering;Blood - brain barrier anatomy;Blood Vessels;cancer biomarkers;cancer cell;Cancer Detection;cancer radiation therapy;cancer therapy;Cell Death;Cell Physiology;Cell surface;Cells;Clinic;Clinical;Clinical Trials;Collaborations;Combined Modality Therapy;contrast enhanced;Contrast Media;Data;Development;Diagnostic Imaging;Diameter;Doctor of Philosophy;Dose;Early treatment;effectiveness evaluation;Endothelium;Ensure;Evaluation;experience;experimental study;Extravasation;Formulation;Frequencies;Funding;Goals;Grant;Head and Neck Cancer;Histologic;Hour;human model;Image;imaging approach;imaging biomarker;Immunocompromised Host;improved;improved outcome;in vivo;Kinetics;Link;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Measures;Mechanics;Mediating;Medical;member;meter;Methodology;Methods;Microbubbles;Modeling;Modulus;Monitor;mouse model;multidisciplinary;Mus;nanobubble;Neoplasms in Vascular Tissue;neoplastic cell;novel;Oryctolagus cuniculus;Patients;Performance;Permeability;Pharmaceutical Preparations;photoacoustic imaging;physical property;Physicians;Physics;Prediction of Response to Therapy;predictive marker;predictive tools;Production;programs;prostate cancer model;Prostate Cancer therapy;Protocols documentation;Publications;Radiation;Radiation Dose Unit;Radiation induced damage;Radiation Oncology;radiation response;Radiation therapy;Radiation-Sensitizing Agents;radio frequency;Radiosensitization;rapid detection;Reactive Oxygen Species;receptor;Research;research clinical testing;Research Personnel;Residual state;Resolution;response;Scientist;Sensitivity and Specificity;side effect;Signal Transduction;Solid Neoplasm;Sonication;success;synergism;Techniques;Technology;Testing;theranostics;Therapeutic;Time;tissue oxygenation;Tissues;tool;translational approach;Translations;Treatment Efficacy;Treatment Failure;treatment optimization;treatment response;Treatment Step;tumor;Ultrasonics;ultrasound;uptake;Vascular Endothelium;Work

PROJECT_TITLE: Enhancement of tumor radiation response by ultrasound-driven nanobubble stimulation

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Multiple Endocrine Neoplasia Type 1 (MEN1/MENIN) has emerged as an important drug target for subsets of aggressive acute leukemia due to successes in clinical trials of small molecule MENIN inhibitors. In this proposal we aim to further understand the mechanism by which these inhibitors produce a therapeutic effect by studying a newly discovered E3 ligase involved in drug dependent MENIN protein degradation which appears to be essential for therapeutic activity. Inspired by our preliminary data that lower MENIN protein levels are essential for MENIN inhibitor sensitivity we further aim to develop a new therapeutic strategy of small molecule MENIN protein degraders that can rapidly and more deeply deplete MENIN protein, all with the intention of improving outcomes for patients with acute leukemias and furthering the understanding of the function of this emergent drug target.

PI_NAMEs: CUTLER, JEVON  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Advisory Committees;Automobile Driving;Award;Binding;Biochemical;Biological Assay;Biology;Cell Line;Chimeric Proteins;Chromatin;Clinical Trials;Co-Immunoprecipitations;Complex;CRISPR library;Data;design;Development;drug sensitivity;Drug Targeting;Environment;experience;experimental study;Funding;Gastrointestinal Stromal Tumors;Gene Expression;Genetic;Genetic Transcription;Goals;Grant;high risk;Ikaros protein;Imides;immunoregulation;improved;improved outcome;in silico;In Vitro;in vivo;inhibitor;Intention;interest;Lead;Leadership;leukemia;Leukemic Cell;Lysine;Malignant Neoplasms;Manuscripts;Mass Spectrum Analysis;Mediating;Menin;Mentors;Mentorship;Methods;Methyltransferase;MLL gene;multicatalytic endopeptidase complex;Multiple Endocrine Neoplasia Type 1;Mutate;novel;novel strategies;novel therapeutic intervention;NPM1 gene;NUP98 gene;Oncogenic;Outcome;Patient-Focused Outcomes;Pharmaceutical Preparations;Play;Pre-Clinical Model;prevent;Process;programs;Protac;protein degradation;protein function;Proteins;recognins;Regulation;Reporter;Reporting;Research;Research Personnel;Resistance;Resources;response;Role;RUNX1 gene;skills;small molecule;success;System;targeted treatment;Therapeutic;Therapeutic Effect;tool;Training;transcription factor;Transcriptional Regulation;transcriptome sequencing;tumorigenic;Ubiquitin;ubiquitin-protein ligase;Work;Writing

PROJECT_TITLE: Targeting Menin Protein Stability In AML

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

PHR: PROJECT NARRATIVE Despite the recent approval of targeted agents such as acalabrutinib (A), venetoclax (V), and obinutuzumab (O), outcomes for patients with high risk, TP53-aberrant chronic lymphocytic leukemia (CLL) remain suboptimal. This project aims to evaluate, through a phase 2, investigator-initiated clinical trial, whether a triplet combination regimen of AVO is effective as time-limited therapy for previously untreated patients with high risk CLL. We will utilize innovative functional laboratory tests such as BH3 profiling and high-throughput kinase activity mapping, as well as genomic analyses, to study samples from the patients on the trial to predict which patients will respond best to the AVO regimen and what resistance mechanisms emerge in patients treated with this novel regimen.

PI_NAMEs: DAVIDS, MATTHEW S (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Achievement;Agammaglobulinaemia tyrosine kinase;anti-CD20;Apoptotic;B lymphoid malignancy;B-Cell Leukemia;BCL2L1 gene;Biological Assay;Chronic Lymphocytic Leukemia;chronic lymphocytic leukemia cell;Clinical;clinical predictors;Clinical Trials;Combined Modality Therapy;comorbidity;Data;Dependence;design;Disease;efficacy evaluation;Elderly;Elements;experience;Family member;Flow Cytometry;Future;Generations;Genes;genomic predictors;Genomics;Genotype;Goals;Grant;Head;Heme;high risk;In complete remission;individualized medicine;inhibitor;innovation;Karyotype;Laboratories;Laboratory Study;leukemia treatment;leukemia/lymphoma;Maps;MCL1 gene;Mitochondria;Monoclonal Antibody CD20;Multi-Institutional Clinical Trial;Mutation;next generation sequencing;novel;optimal treatments;Patient-Focused Outcomes;Patients;Pattern;personalized decision;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;Phenotype;Phosphorylation;Phosphotransferases;Population;predicting response;Principal Investigator;Progression-Free Survivals;protein B;Protein Family;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;Regimen;Research Personnel;Residual Neoplasm;Resistance;Resistance development;resistance mechanism;response;response biomarker;Rest;Risk;Safety;Sampling;Sampling Studies;Somatic Mutation;standard of care;Subgroup;survival prediction;targeted agent;Technology;Testing;Therapeutic;therapy duration;Therapy trial;Time;tositumomab;Toxic effect;TP53 gene;treatment duration;treatment response;Triplet Multiple Birth;Tyrosine Kinase Inhibitor;Writing

PROJECT_TITLE: Optimizing novel agent combination therapy for previously untreated, high risk chronic lymphocytic leukemia

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: This R01 application will design and develop a targeted nanoparticle that possesses the ability to selectively knockdown multiple proteins in the lung cancer cells that are responsible for drug resistance and thereby sensitize the solid tumors to drug therapy. The academic institutions (MU and UCSF (subcontract)) will work together to assess the nanoparticles in clinically relevant patient derived organoids and patient derived mouse xenografts.

PI_NAMEs: KANNAN, RAGHURAMAN  (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: A549;Abate;Animal Model;Antibodies;Biodistribution;Bypass;Cancer Patient;cancer therapy;Cell Line;Cells;Characteristics;Charge;Clinical;clinical development;Clinical Trials;clinically relevant;combat;Compensation;crosslink;Data;design;Development;Dose;Drug Kinetics;Drug resistance;drug sensitivity;Engineering;Epidermal Growth Factor Receptor;Evaluation;Exhibits;functional group;Future;Gelatin;Genes;Immunohistochemistry;improved;In Vitro;in vivo;inhibitor therapy;Institution;knock-down;Lead;lead candidate;Libraries;Literature;lung cancer cell;Malignant neoplasm of lung;Medical;Methodology;Modeling;Molecular Target;mouse model;Mus;mutant;Mutate;nanomedicine;nanoparticle;nanotechnology platform;nanotherapeutic;NF-kappa B;Non-Small-Cell Lung Carcinoma;novel;novel strategies;Organoids;Pathway interactions;patient derived xenograft model;Patients;Penetration;Pharmacotherapy;Phenotype;Play;Proteins;Receptor Protein-Tyrosine Kinases;Resistance;Sampling;side effect;Signal Pathway;Signal Transduction;Small Interfering RNA;small molecule inhibitor;Solid Neoplasm;spheroids;success;Survival Rate;therapeutic evaluation;therapeutic nanoparticles;therapy outcome;Tissues;transcriptome sequencing;Treatment Efficacy;treatment response;tumor;tumor growth;Tyrosine Kinase Inhibitor;uptake;Work;Xenograft procedure

PROJECT_TITLE: Engineering Dual-Targeted Nanoplatforms to Effectively Treat NSCLC.

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Maternal Health;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth;Women's Health Research

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative Although telehealth has been widely implemented during the COVID-19 pandemic, real- world data remain limited regarding the disparities in perinatal telehealth uptake among vulnerable pregnant women and the associated health disparities. Understanding the role of telehealth uptake in mitigating the impacts of the COVID-19 pandemic on minority pregnant women and those in rural communities is essential to developing necessary policies for equitable adaptation of telehealth for maternity care. Our study will address vital gaps in evidence regarding the consequences of the pandemic, distinct state telehealth policies, and telehealth uptake on the four aspects of maternity care: access, quality, outcomes, and expenditures.

PI_NAMEs: HUNG, PEIYIN  (contact);LI, XIAOMING

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Acceleration;Adopted;Advocate;American;asynchronous encounter;Bayesian Analysis;behavioral health;Big Data;Birth;Black Populations;black women;Caring;Clinical;clinical decision support;clinical decision-making;cohort;Communication;Community Surveys;Complement;Coronavirus;cost;Cost Savings;Costs and Benefits;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 susceptibility;Data;data harmonization;data modeling;Data Reporting;data sharing;Databases;Death Certificates;Death Rate;Development;Discipline of obstetrics;Disparity;disparity reduction;Economics;Electronic Health Record;Electronic Mail;Epidemiologist;Equity;ethnic disparity;Ethnic Minority Women;Ethnic Origin;Evidence based practice;Expenditure;experience;Financial Hardship;Florida;Fright;Future;gaps in access;Geography;Goals;Health;health care quality;health disparity;Health Expenditures;Health Insurance;Health Policy;Health Services;Health Services Accessibility;Healthcare;Healthcare Systems;Hispanic Populations;Hispanic Women;Hospitalization;Hybrids;Income;Infant Health;infant outcome;infection rate;infection risk;innovation;Internet;Interruption;Location;Machine Learning;Maternal Health;Maternal Health Services;maternal outcome;Measures;Medicaid;Methods;Minority;Minority Women;models and simulation;multidisciplinary;Outcome;pandemic disease;pandemic impact;pandemic response;Patient Self-Report;Patients;Perinatal;Persons;Policies;Population;population based;postpartum care;Pregnant Women;prenatal;Provider;Psychologist;Psychosocial Stress;public health emergency;Quality of Care;Race;racial disparity;racial diversity;racial minority women;Recurrence;Regulation;Relaxation;remote patient monitoring;Research;Research Personnel;Resources;Role;Rural;Rural Community;rural disparities;Rural Health;Rural Hospitals;Rural Minority;Rural Population;SARS-CoV-2 infection;scale up;Security;Services;simulation;Site;social;Social isolation;South Carolina;Statutes and Laws;synchronous contact;telehealth;Testing;Transportation;transportation access;Travel;trend;Unemployment;United States;uptake;urban disparity;Urban Population;urban residence;Visual;waiver;Woman;women of color

PROJECT_TITLE: Mitigating effects of telehealth uptake on disparities in maternal care access, quality, outcomes, and expenditures during the COVID-19 pandemic


NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Urologic Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Uropathogenic E. coli (UPEC) are the main etiologic agent of urinary tract infections in humans that result in enormous health and social costs across the globe. There is now evidence that UPEC strains routinely colonize food animals serving as a likely link between food-animal E. coli and human UTIs. This longitudinal study will define domestic animal host features of UPEC and model human exposures to uropathogenic E. coli (UPEC) in poor communities of Northwest Ecuador to understand the drivers of exposure to UPEC among households.

PI_NAMEs: EISENBERG, JOSEPH N. S. (contact);GRAHAM, JAY PAUL

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acute;Animal Feed;Animals;Bacteremia;Behavior;Biological Assay;Blood specimen;burden of illness;Cessation of life;Chickens;Clinical;Communities;Comparative Genomic Analysis;comparative genomics;cost;Dairy Products;Data;Demographic Factors;Diagnosis;Diagnostic;Diarrhea;Domestic Animals;Domestic Fowls;Ecology;Ecuador;Elements;Environment;Epidemiology;Escherichia coli;Etiology;experience;Exposure to;Genetic Markers;Goals;Health;high risk;Home environment;Hospitalization;Hospitals;Household;Housing;Human;human model;Hygiene;Incidence;Income;Individual;Infection;Infrastructure;inpatient service;Lead;Link;Livestock;Longitudinal Studies;low and middle-income countries;marginalized community;Measures;Meat Products;Methods;Mobile Genetic Elements;modifiable risk;Morbidity - disease rate;neglect;Outcome;Pathway interactions;Persons;pet animal;Play;poor communities;Poultry Products;Pregnant Women;Process;prospective;Prospective Studies;recurrent infection;Research;Resource-limited setting;Review Literature;Risk;Risk Factors;Role;Sanitation;Site;social;Socioeconomic Factors;socioeconomics;Source;spatiotemporal;stool sample;Surveys;Therapeutic Intervention;transmission process;United States;Urinary tract infection;Uropathogenic E. coli;Vector-transmitted infectious disease;Water;women patients;Zoonoses

PROJECT_TITLE: Zoonotic Uropathogenic Escherichia coli in Northwest Ecuador: Incidence and Risk Factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Substance Misuse

ORG_CITY: LOUISVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: Project Narrative About 2.5% of the US population is affected by alcohol-associated liver disease (ALD), which represents the 8th most common cause of mortality. Currently there is no FDA approved therapy available for the treatment of ALD. This project will examine phosphodiesterase 4 (PDE4)-mediated pathogenic pathways in ALD. The findings of this project will lead to the development of novel therapies targeting PDE4 for treatment of ALD.

PI_NAMEs: GOBEJISHVILI, LEILA  (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: ADD-1 protein;Affect;alcohol effect;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Animal Model;Apoptosis;Attenuated;Automobile Driving;cell injury;Cell model;Cell Physiology;Cessation of life;Complex;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;CYP2E1 gene;Cytochrome P450;Data;Development;Disease;Enzymes;Ethanol;Fatty Acids;Fatty Liver;FDA approved;Genes;genetic manipulation;Goals;H19 gene;Heavy Drinking;Hepatic;Hepatocyte;HIF1A gene;Hydrolysis;hypoxia inducible factor 1;Impairment;In Vitro;in vitro Model;in vivo;Inflammatory;inhibitor;Injury;Knockout Mice;lipid biosynthesis;lipid metabolism;Liver;Liver diseases;liver injury;MAPK8 gene;Mediating;member;Metabolic;Mitogen-Activated Protein Kinases;mortality;new therapeutic target;novel;oxidation;Pathogenesis;Pathogenicity;Pathway interactions;Patients;PDE4B;phosphatase-1 kinase;phosphodiesterase IV;phosphoric diester hydrolase;Phosphoric Monoester Hydrolases;Phosphorylation;Play;Population;preclinical study;Process;Regulation;response;Role;Second Messenger Systems;Signal Transduction;Specificity;Toxic effect;transcription factor;Transcriptional Regulation;United States;Untranslated RNA;Up-Regulation;Work

PROJECT_TITLE: Phosphodiesterase 4 mediated pathogenic mechanisms in alcohol associated liver disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The project seeks to define the full ligand space monitored by the large gene family of plant cell surface receptor kinases. Findings will inform mechanisms of specificity in peptide recognition by receptor ectodomains. Plant receptor pathways will be used for orthogonal control of mammalian signaling pathways with applications in biotechnology and medicine.

PI_NAMEs: STEINBRENNER, ADAM D (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Agonist;Amino Acid Substitution;Animals;BAK1 gene;Binding;Binding Sites;Biotechnology;Cell Surface Receptors;design;DNA Library;Engineering;Epitopes;Evolution;extracellular;G-Protein-Coupled Receptors;Gene Family;Genes;Genome;Genomics;Germ Lines;Heterodimerization;Human;Human Engineering;Immune;Immune signaling;Immune system;Immunoglobulins;Immunologic Receptors;Inflammation;insight;Leucine-Rich Repeat;Libraries;Life;Ligand Binding;Ligands;Medicine;Molecular Biology;Monitor;Natural Immunity;network architecture;Orphan;pathogen;Pathway interactions;Peptides;Phosphorylation;Phosphotransferases;Plant Model;Plants;protein aminoacid sequence;Protein Kinase;Proteins;receptor;Receptor Activation;Receptor Gene;reconstruction;Reporter;scaffold;sensor;Signal Pathway;Signal Transduction;Specificity;Structure;synthetic construct;Toll-like receptors;tool;Variant;Yeast Model System

PROJECT_TITLE: Immunodiversity of plant receptor kinase networks for synthetic circuit design

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Lung;Pulmonary Fibrosis;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease with limited treatment options due to poorly understood pathogenic mechanism and highly variable clinical course. This proposal aims to apply PET-MR imaging to quantify molecular abnormalities in the lungs of IPF patients and determine if such measures can predict the pace of disease progression and determine whether the patient is responding to anti- fibrotic therapy.

PI_NAMEs: CARAVAN, PETER D (contact);CATANA, CIPRIAN

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: activity marker;Address;Air;Algorithms;anatomic imaging;Animal Model;antifibrotic treatment;Area;attenuation;Biopsy;blood fractionation;Blood Vessels;Breathing;Clinical;Clinical Trials;Collagen;Collagen Type I;contrast enhanced;Data;density;Detection;Diagnosis;Disease;Disease Progression;drug development;Early Diagnosis;Early treatment;fibrogenesis;Fibrosis;follow-up;Goals;healthy volunteer;High Resolution Computed Tomography;Histologic;idiopathic pulmonary fibrosis;Image;imaging approach;Imaging Device;imaging modality;improved;in vivo;Individual;individual patient;Kinetics;Lung;lung imaging;lung injury;Magnetic Resonance Imaging;Maps;Measures;Metabolism;Methods;Modality;Molecular;Molecular Abnormality;molecular imaging;Monitor;Morphologic artifacts;Morphology;Motion;optimal treatments;outcome prediction;Pathogenicity;Patient Care;Patients;Photons;Physiology;Positron-Emission Tomography;Predisposition;Protocols documentation;Protons;Pulmonary Fibrosis;pulmonary function;Pulmonary function tests;quantitative imaging;radiological imaging;respiratory;Scanning;segmentation algorithm;Selection for Treatments;Signal Transduction;Stable Disease;Staging;Structure of parenchyma of lung;Testing;Time;Tissues;transmission process;treatment response;uptake;Variant;Work

PROJECT_TITLE: PET-MR Imaging of pulmonary fibrosis

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Nucleoside reverse transcriptase inhibitors (NRTIs) have potent activity against HIV infection but their clinical use is limited by significant adverse drug reactions (ADR). In the present proposal we seek to determine the contribution of dysregulated lysosomal signaling to NRTI ADR, profile and select compounds for NRTI ADR- free properties, and then functionally test whether those candidates present with less ADR in preclinical models of HIV infection and toxicity. The proposed research is relevant to public health because we anticipate that this research project will provide a foundation for the development of safe and effective NRTI for better treatment and quality of life in patients undergoing HIV therapies.

PI_NAMEs: GOVINDARAJAN, RAJGOPAL  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Adenosine;Adherence;Adult;adult stem cell;adverse drug reaction;Agonist;Anti-HIV Agents;Autophagocytosis;base;Biochemical;Blood;Bone Marrow Transplantation;Cell surface;chemical synthesis;cheminformatics;Chronic;Clinical;clinical phenotype;clinically relevant;Coupled;Development;Dose;drug development;drug efficacy;Drug Kinetics;experimental study;FDA approved;Foundations;FRAP1 gene;Functional disorder;Gene Modified;Generations;Genetically Engineered Mouse;Goals;Hepatotoxicity;HIV;HIV Infections;HIV therapy;Homeostasis;Hyperpigmentation;Impairment;Inflammation;Inflammatory;inhibitor;inhibitor therapy;insight;Integrase Inhibitors;Knock-out;Knockout Mice;Knowledge;lipidomics;Lipodystrophy;Lysosomes;Maintenance;Mass Spectrum Analysis;Metabolic;metabolomics;Mitochondria;Modeling;Modification;Molecular;Molecular Probes;mouse model;Mucous Membrane;Mus;Myelosuppression;novel;nucleoside analog;Nucleoside Transporter;Nucleosides;Organ;Outcome;Pancreatitis;Pathogenesis;Pathway interactions;Patient Compliance;Patients;Pericarditis;Peripheral Nervous System Diseases;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;pharmacophore;Pre-Clinical Model;prevent;Property;Protease Inhibitor;Public Health;Quality of life;Recycling;regenerative;Regimen;Research;Research Project Grants;Reverse Transcriptase Inhibitors;Role;screening;Screening procedure;Sensorineural Hearing Loss;Severities;Shapes;Signal Transduction;small molecule libraries;spatiotemporal;stem cell exhaustion;stem cell function;stem cell homeostasis;stem cells;Structure;Symptoms;Testing;Therapeutic;Tissue Differentiation;Tissue Engineering;tissue regeneration;tissue repair;Tissues;Toxic effect;Treatment Efficacy;treatment optimization;Vertebral column;Work

PROJECT_TITLE: Anti-HIV NRTIs and the lysosomal toxicity

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Aging;Anxiety Disorders;Atherosclerosis;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Prevention;Sleep Research

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: The study is designed to evaluate the association between insomnia and cardiovascular risk biomarkers among persons with posttraumatic stress disorder. This study will determine whether improvements in insomnia symptoms with reduce CVD risk biomarkers and improve quality of life.

PI_NAMEs: BECKHAM, JEAN C. (contact);SHERWOOD, ANDREW

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: actigraphy;Address;Adult;Alcohol abuse;Ambulatory Blood Pressure Monitoring;arm;Arousal;associated symptom;Atherosclerosis;atherosclerosis risk;Behavioral;behavioral sleep intervention;Biological Markers;biological sex;Blood Pressure;brachial artery;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Catecholamines;Chronic;cigarette smoking;Cognitive Therapy;Comorbid Insomnia;comorbidity;comparison control;cost;Data;design;Development;Disabling;Evaluation;Event;evidence base;Exposure to;follow-up;Goals;Health behavior;Heterogeneity;Hour;improved;improvement on sleep;indexing;Individual;innovation;interest;Intervention;Knowledge;Link;Lipids;Measurement;Measures;Mediating;Medical;medication compliance;men;Mental Depression;Mental disorders;middle age;Minority Status;Morbidity - disease rate;mortality;multimodality;Outcome;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Phenotype;poor sleep;Population;post intervention;Post-Traumatic Stress Disorders;Prospective Studies;psychiatric comorbidity;Psychotherapy;Quality Indicator;Quality of life;Randomized;Research;response;Risk;Risk Factors;Severities;Sleep;Sleep Disorders;Sleep disturbances;sleep onset;sleep quality;Sleeplessness;Sympathetic Nervous System;Symptoms;Testing;Therapeutic;Time;Trauma;traumatic event;treatment response;urinary;Vascular Endothelium;Woman;Work

PROJECT_TITLE: An evaluation of insomnia treatment to reduce cardiovascular risk in patients with posttraumatic stress disorder

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Glioblastoma, a lethal primary brain tumor, has limited treatment options; the current standard therapy with combined chemotherapy (with a drug called temozolomide) and radiation therapy results in a median survival of only 16-18 months highlighting the urgent need for novel therapies. In a search for drugs that can overcome resistance to chemotherapy and radiation therapy, we have identified that blocking the activity of heat shock protein 90 (Hsp90), a protein complex that is critical for tumor cell survival and treatment resistance, using a novel drug called Onalespib which we have shown can cross the blood brain barrier, can make glioma cells more sensitive to temozolomide and radiation therapy, slow down glioma growth in animals and extend their survival. Building on these promising results, we will conduct a trial that will assess the clinical benefit of blocking Hsp90 using onalespib along with chemoradiation in brain tumors and which bears promise of providing a new treatment option for patients with glioblastoma as well as providing valuable new information related to whether onalespib can block its targets in tumor tissue that can benefit studies in other cancers which are exploring the effects of Onalespib.

PI_NAMEs: PUDUVALLI, VINAY K (contact);SAMPATH, DEEPA

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;Adjuvant;Adult;Affect;Aftercare;aggressive therapy;Alkylating Agents;angiogenesis;Animal Model;Animals;antitumor effect;blood-brain barrier crossing;Brain Neoplasms;Bypass;cancer cell;Cancer Center;Cell Line;Cell Survival;Cells;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Client;Clinical;Clinical Trials;co-clinical trial;Combination Drug Therapy;Complex;conventional therapy;Correlative Study;CRISPR/Cas technology;cytotoxic;Data;Defense Mechanisms;Development;Development Plans;DNA;DNA Repair;DNA Repair Gene;Drug Kinetics;ds-DNA;efficacy evaluation;efficacy trial;Epidermal Growth Factor Receptor;epidermal growth factor receptor VIII;Evolution;Funding;Future;Generations;Glioblastoma;Glioma;glioma cell line;Grant;Growth;Heat shock proteins;Heat-Shock Proteins 90;Heat-Shock Response;Heterogeneity;HSP 90 inhibition;Human;improved;improved outcome;In Vitro;in vivo;Individual;inhibitor;insight;Institution;Invaded;knock-down;Malignant neoplasm of brain;Malignant Neoplasms;Maximum Tolerated Dose;Mediating;Mediator;member;Methylation;MGMT gene;Microdialysis;migration;Mismatch Repair;Modeling;Molecular Chaperones;mouse model;Mus;neoplastic cell;Newly Diagnosed;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Oncology;Oncoproteins;Operative Surgical Procedures;Outcome;overexpression;Pathway interactions;patient subsets;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phase;phase 2 study;Phase I Clinical Trials;phase I trial;phase II trial;Plasma;Positioning Attribute;pre-clinical;Primary Brain Neoplasms;Process;protein complex;Protein Family;Proteins;radiation effect;Radiation therapy;Radiation-Sensitizing Agents;Randomized;Recurrence;Recurrent tumor;Resistance;resistance mechanism;response;Role;Sampling;Schedule;Serum;Signal Transduction;Slice;Specimen;stem cells;Stress;temozolomide;therapy outcome;therapy resistant;Tissues;Toxic effect;transcriptome;transcriptome sequencing;Treatment Failure;trial planning;tumor;tumor growth;tumor heterogeneity;Tumor Tissue;Up-Regulation;Zebrafish

PROJECT_TITLE: A Novel Hsp90 Inhibitor as a Chemo and Radiosensitizer in Adults with Glioblastoma


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Fragile X Syndrome;Genetic Testing;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: TUCSON

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will contribute to our understanding of the basis of language impairments among individuals at high risk for neurodegenerative disorders, as well as links between language, executive functions, and quality of life. This study will examine language production in a cross- sectional sample of adult males and females with the FMR1 premutation and healthy matched controls, and in relation to a key cognitive domain among premutation carriers - executive function. Given the prevalence of the FMR1 premutation (females: 1/~150, males: 1/~470), this work has the potential to expand our understanding of candidate language markers associated with an FMR1-associated neurodegenerative condition (i.e., FXTAS) and the phenotypic scope of the FMR1 premutation, thus informing links between genetics and language.

PI_NAMEs: MALTMAN, ALEXIS NELL (contact)

PROJECT_TERMS: Address;Adult;Affect;Age;age related;age related changes;age related neurodegeneration;Age Years;Age-associated memory impairment;aged;Aging;Alzheimer's Disease;candidate identification;candidate marker;cerebral atrophy;Clinical;Cognitive;comparison control;Data;design;Diagnosis;disability;Disease;Disease Marker;Disease Progression;Executive Dysfunction;executive function;Exhibits;Female;FMR1 gene;FMR1 Premutation;Functional disorder;FXTAS;Gait Ataxia;Genetic;genetic variant;Goals;Health;healthy aging;high risk;Impaired cognition;Individual;Intention Tremor;Interpersonal Relations;Knowledge;Language;language impairment;lexical;Link;Literature;male;Measures;men;Mental Health;Mission;mutation carrier;Names;National Institute on Deafness and Other Communication Disorders;Nature;Nerve Degeneration;Neurocognitive Deficit;Neurodegenerative Disorders;Nucleotides;Participant;Patient Self-Report;Personal Satisfaction;Phenotype;physical conditioning;pre-clinical;Prevalence;Production;Productivity;Public Health;Quality of life;Questionnaires;recruit;Research;Risk;Sampling;Semantics;sex;Standardization;Strategic Planning;Subgroup;Testing;United States;United States National Institutes of Health;Variant;verbal;virtual;Woman;Women's study;Work;X Chromosome

PROJECT_TITLE: Language as a Candidate Marker of FXTAS in FMR1 Premutation Carriers


NIH_SPENDING_CATS: Immunization;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Vaccine Related

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative  Staphylococcus bacteria are the primary cause of healthcare-associated infections in neonatal intensive care units and the leading cause of skin and soft tissue infections worldwide, necessitating novel treatments that enhance early-life immunity. Although innate lymphoid cells and innate-like T cells comprise a substantial effector population in neonatal tissues, their contributions to immunity during this period remain poorly understood. Combining state-of-the-art approaches from immunology, genetics, and bioinformatics, this project will further our understanding of early-life immunity and lead to the development of novel therapeutics.

PI_NAMEs: CONSTANTINIDES, MICHAEL GEORGE (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: adaptive immunity;Antibodies;Antigen Receptors;Antigens;Bacteria;Bacterial Infections;Bioinformatics;Cells;Characteristics;chemokine receptor;Child;cytokine;Development;emerging antibiotic resistance;Genetic;Genus staphylococcus;Germ Lines;Goals;healthcare-associated infections;Homing;Human;humanized mouse;Immune;Immune system;Immunity;Immunologic Memory;Immunologic Receptors;Immunology;Impetigo;in vivo;Infection;Infectious Skin Diseases;innovation;Integrins;Life;Lymphocyte;Lymphoid Cell;maternal vaccination;Mediating;Modeling;Molecular;Mus;Neonatal;Neonatal Intensive Care Units;novel;novel therapeutics;pathogen;Pattern;Population;prevent;receptor;Receptor Gene;response;Role;secondary lymphoid organ;Sepsis;Soft Tissue Infections;Specificity;standard care;Staphylococcal Infections;Staphylococcal Scalded Skin Syndrome;T-Cell Receptor;T-Lymphocyte;Tissues;vaccine access

PROJECT_TITLE: Innate lymphocyte responses to early-life infections


ADMINISTERING_IC: ES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: OVERALL Narrative METALS The University of New Mexico Metals Exposure and Toxicity Assessment on tribal Lands in the Southwest Superfund Research Center (METALS) will continue strong partnerships with Indigenous partners from Navajo Nation and Laguna Pueblo to understand community toxicity resulting from exposure to metal mixtures in legacy waste from the Cold War weapons build-up. Millions of tons of waste remain at >4500 abandoned uranium mine sites in the 15 Western states that are home to >50% of the US Indigenous population. Our integrated team focuses on community informed, solution-oriented team science to reduce the risk of identified chronic disease risk from these exposures through development of partnered environmental and clinical interventions.

PI_NAMEs: CERRATO, JOSE MANUEL (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: Address;Age;Agriculture;Arsenic;Autoantibodies;Belief;Biological;Biological Availability;Biological Monitoring;Bioreactors;Bioremediations;Cells;Chronic;Chronic Disease;Clinical;Clinical Trials;Collaborations;Communities;community engaged approach;community engaged research;community partners;community partnership;Congresses;cost effective;cytokine;Data;design;Development;disorder risk;DNA Repair;Dose;Economics;Ensure;Environment;Equilibrium;exposure route;Exposure to;Family;federal policy;Funding;fungus;geochemistry;Health;Home;Hypertension;Immune;immune function;Immune System Diseases;Immunity;improved;Indigenous;Inflammation;Inflammatory;Ingestion;Inhalation;Intervention;Language;Left;Link;Lung;Medial;Metabolic Biotransformation;metal complex;Metal exposure;metal poisoning;Metals;Mining;Modeling;Movement;multidisciplinary;multimodality;nanoparticle;Native-Born;Navajo;New Mexico;novel;novel strategies;Nuclear Weapon;Oral;Oxidative Stress;particle;Particulate;Pathway interactions;Phase;physical property;Plants;Policies;Policy Maker;Population;Prevalence;Printing;Process;Production;programs;Property;Pueblo Race;Reference Values;remediation;Research;Research Personnel;Resources;response;Rest;Risk;Risk Reduction;Role;Route;Safety;Science;Signal Recognition Particle;Site;sound;Superfund;Suspensions;Symbiosis;Testing;therapy design;Thinking;Time;Tissues;Toxic effect;toxic metal;translational approach;Translations;Transmission Electron Microscopy;tribal lands;Tribes;Universities;uptake;Uranium;Vanadium;vulnerable community;War;wasting;weapons;Work;Zinc

PROJECT_TITLE: UNM Metals Exposure and Toxicity Assessment on tribal Lands in the Southwest (METALS) Superfund Research Program


NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Rural Health

PHR: Project #1 – BioProject on Community Exposures (BP Comm) - Project Narrative This project addresses Native American community concerns about health effects associated with exposure to uranium and co-occurring metals found at legacy uranium mining waste sites. These studies will investigate the biologic consequences of exposure to metals in an exposed population. Complementary studies in experimental models are designed to identify mechanisms of toxicity that can be targeted for future population- based interventions.

PI_NAMEs: HUDSON, LAURIE G (contact)

PROJECT_TERMS: Acute;Address;Adult;Adverse effects;Antioxidants;Arsenic;Atherosclerosis;Autoimmune Diseases;Autoimmunity;Biological;biological adaptation to stress;Biological Markers;Biological Monitoring;Blood Vessels;Cells;Chronic;Chronic Disease;Clinical Trials;Collection;Communities;Community Health;community partners;cytokine;cytotoxicity;Data;Decision Making;Detection;Development;Diabetes Mellitus;dietary;Disease;DNA Damage;DNA Repair Gene;DNA Repair Inhibition;Environment;Environmental Exposure;Environmental Health;Environmental Protection;Evaluation;Experimental Models;experimental study;exposure pathway;exposure route;Exposure to;Future;Generations;Goals;Health;Health Priorities;Health Surveys;Human;Hypertension;Immune;Immune Targeting;Immunologics;immunoregulation;immunotoxicity;Individual;Inflammation;Inflammatory;Inflammatory Response;insight;Intervention;Kidney Diseases;Knowledge;Link;Lung;macromolecule;member;Metal exposure;metal poisoning;Metals;Micronutrients;Mining;model design;Modeling;Modification;Native American community;New Mexico;Nutrient;Nutrition Surveys;Outcome;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;Pattern;Population;Population Intervention;Population Study;Process;Production;programs;Proteins;Publishing;Reactive Oxygen Species;Research;Risk;Risk Assessment;Risk Reduction;Sampling;Science;Selenium;Signal Recognition Particle;Signal Transduction;Site;Superfund;Testing;therapy development;Time;Toxic effect;toxic metal;tribal lands;Universities;uptake;Uranium;Vanadium;wasting;Work;Zinc;Zinc Fingers

PROJECT_TITLE: Biomarkers and mechanisms of metal and mixed metal exposures


NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health

PHR: Project 2 - ENVIRONMENTAL PROJECT 2 – ESE PM - NARRATIVE This project examines the potential exposures through inhalation and ingestion of toxic metals carried in ultrafine-grained particulate matter (PM) especially nanoparticles experienced by tribal communities living in close proximity to abandoned uranium mines (AUMs). The bioavailability and bioacessibility of nanoparticulates for uptake into agricultural crops via root and folial systems will be examined by field and experimental studies. Understanding these pathways for community exposures to metals is essential for providing comprehensive, real-world exposure estimates for risk reduction and prioritization strategies.

PI_NAMEs: BREARLEY, ADRIAN J (contact)

PROJECT_TERMS: absorption;Address;Adsorption;Affect;agricultural activity;Agricultural Crops;Agriculture;Air;Airborne Particulate Matter;Arizona;Arsenic;atmospheric modeling;Biological Availability;Characteristics;Chemicals;Communities;community living;Copper;Data;Data Set;Deposition;Dust;Electron Microscopy;Electron Probe Microanalysis;Environment;Environmental Engineering technology;Environmental Pollution;Environmental Science;Environmental Wind;experience;experimental study;exposed human population;exposure pathway;Exposure to;field study;fine particles;Goals;Grain;hazard;Health;Human;Hydrophobic Interactions;Image;indigenous community;Ingestion;Inhalation;Inhalation Exposure;innovation;interest;Investigation;Measurement;member;Metal exposure;metal poisoning;Metals;Microscopy;Minerals;Mining;Modeling;Monitor;Morphology;nano;nanoparticle;nanoparticulate;Native American community;Navajo;New Mexico;novel strategies;Particle Size;Particulate;Particulate Matter;Pathway interactions;performance site;Plant Leaves;Plant Roots;Plants;Poaceae;Process;programs;Property;Public Health;Pueblo Race;rapid detection;receptor;remediation;Research;Resolution;Risk;Risk Assessment;Risk Estimate;Risk Reduction;Sampling;Signal Recognition Particle;Site;Soil;Solid;Solubility;Source;Southwestern United States;Spectrum Analysis;Squash;Stomas;Structure;submicron;Superfund;Suspensions;System;Techniques;Testing;tool;Toxic effect;toxic metal;tribal community;tribal lands;Ultrafine;Uncertainty;uptake;Uranium;Vanadium;vulnerable community;Vulnerable Populations;wasting;Waxes

PROJECT_TITLE: Transport and bioavailability of U and co-occurring metals in nanoparticulate matter on tribal lands affected by mining legacy


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Skin Cancer

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Harnessing the power of the T cell response to kill tumor cells is proving to be a highly effective anti-cancer strategy. Most approaches focus on re-targeting T cells to better recognize tumor cells. In contrast our approach focuses on improving the quality of the T cell response, to enable T cells to better persist and function in the metabolically challenging environment of the tumor, and this can be layered upon potentially any T cell tumor- targeting strategy.

PI_NAMEs: USHERWOOD, EDWARD J (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Adenocarcinoma Cell;Adoptive Immunotherapy;Adoptive Transfer;Affect;anti-cancer;anti-tumor immune response;Antigens;Area;cancer therapy;Carbon;CD8-Positive T-Lymphocytes;CD8B1 gene;cell motility;Cell Physiology;Cell Survival;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cellular Metabolic Process;chimeric antigen receptor T cells;chromatin remodeling;combat;Cytoprotection;Data;Disease remission;Dominant-Negative Mutation;Energy-Generating Resources;engineered T cells;Engineering;Ensure;Environment;Excision;exhaustion;experimental study;Exposure to;flexibility;Future;Gene Expression Profiling;Gene Expression Regulation;Gene Silencing;Genes;genetic corepressor;Genetic Transcription;Glucose;Glutamine;Glycolysis;Granzyme;Human;Immunity;Immunotherapy;improved;interest;knock-down;Knowledge;Liquid substance;Malignant Neoplasms;MC38;Measures;Mediating;Melanoma;Melanoma Cell;Memory;Metabolic;Metabolic Pathway;Metabolism;migration;Mitochondria;mitochondrial metabolism;Modeling;Molecular;Mus;mutant;neoplastic cell;novel;patient population;Patients;Phenocopy;Phenotype;Reagent;recruit;Reporter;Research;Resistance development;Respiration;response;restraint;Role;Solid Neoplasm;Source;Stable Isotope Labeling;success;Surface;System;T cell differentiation;T cell response;T cell therapy;T-Cell Receptor;T-Lymphocyte;Tamoxifen;Testing;transcription factor;transcription factor UBF;Transcription Repressor;transcriptome sequencing;Translating;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor microenvironment;Up-Regulation

PROJECT_TITLE: Exploiting a novel regulator of immunometabolism to enhance immunotherapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Digestive Diseases;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Racial and Ethnic Minority Health Research;Rural Health

PHR: Communities living around legacy and active uranium and hard rock mines are concerned about metal exposures that may produce adverse health effects. This project evaluates the effects of drinking water exposures to potentially toxic metals (uranium, vanadium, and arsenic) alone and in combination. Our previous work shows that immune and non-immune cells in the gastrointestinal tract receive high exposures to metals leading to immune changes that will be further investigated in animal and human studies.

PI_NAMEs: CASTILLO, ELISEO F (contact)

PROJECT_TERMS: absorption;Address;Affect;Albumins;Animals;Aromatic Hydrocarbons;Arsenic;Autoimmune Diseases;Biological;Biological Markers;biomarker signature;Blood;Cell Differentiation process;Cell Line;Cell surface;Cells;Chronic;Citrates;Collaborations;Colon;Communities;community living;community partners;cytokine;Data;Disease;drinking water;dysbiosis;Electrical Resistance;Elements;Environment;Epithelial Cells;Epithelium;exposure route;Exposure to;fecal microbiome;Feces;Functional disorder;Funding;gastrointestinal;Gastrointestinal tract structure;Goals;gut microbiome;gut microbiota;hard metal;Health;Human;Immune;immune function;Immune System Diseases;Immunity;Immunologics;immunoregulation;immunotoxicity;In Vitro;in vivo;Individual;Inflammation;Inflammatory;inflammatory marker;Ingestion;Inhalation;intestinal epithelium;Intestinal permeability;Intestines;intraepithelial;Intraepithelial T-Lymphocyte;Investigation;Lactoferrin;Lamina Propria;Large Intestine;Leukocyte L1 Antigen Complex;Ligands;Lung;Lymphocyte;Lymphocyte Subset;Lymphoid Cell;member;Membrane;Messenger RNA;Metabolic;Metabolic Marker;Metabolic Pathway;Metabolism;metabolome;metabolomics;metagenomic sequencing;Metagenomics;Metal exposure;metal poisoning;Metals;microbiome;microbiota;mitochondrial metabolism;Modeling;MRL/MpJ Mouse;mRNA Expression;Mus;nanomaterials;New Mexico;novel;Oral;Oral Ingestion;Organoids;Orthovanadate;Oxidative Stress;Oxides;Participant;Particulate;Pathway interactions;Permeability;Phase;Pilot Projects;Predisposition;Production;programs;protein expression;Proteins;receptor;remediation;Research;Sampling;Sampling Studies;Series;Signal Recognition Particle;Site;Small Intestines;Sodium;stool sample;Superfund;T-Lymphocyte;Testing;Tight Junctions;Tissues;Toxic effect;toxic metal;translational study;tribal lands;Universities;Uranium;uranyl acetate;Vanadium;Work;wound healing

PROJECT_TITLE: Mechanisms of Modulation of Gut Immunity by Ingested Uranium and Mixed Metal Exposures


NIH_SPENDING_CATS: American Indian or Alaska Native;Autoimmune Disease;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Racial and Ethnic Minority Health Research;Rural Health

PHR: Project Narrative There is great concern regarding the potential health risks associated with increased exposure to metals due to legacy uranium and hard rock mining in the Southwestern United States. This project evaluates the effects of inhalation exposure to metal-rich particulates alone or in mixtures on immune dysregulation and the potential to lead to lung and systemic autoimmunity. Information gained will provide novel mechanistic insight into the potential risks associated with exposure to airborne metals and their role in metal-mediated immune modulation and disease.

PI_NAMEs: BOLT, ALICIA M. (contact)

PROJECT_TERMS: Address;Antinuclear Antibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;Automobile Driving;Biological Monitoring;bone;Bone Marrow;Cells;Chronic;Chronic lung disease;Coculture Techniques;cohort;Collaborations;Communities;community living;community partners;cytokine;Data;Development;Disease;Dust;Environmental Exposure;Epithelial Cells;Exhalation;exposed human population;Exposure to;extracellular;Geography;Goals;Health;Human;Hyperactivity;Image;imaging platform;Immune;Immune System Diseases;Immunologic Markers;Immunologics;immunoregulation;In Vitro;in vitro Model;Individual;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Inflammatory Response;Inhalation;Inhalation Exposure;inhibitor;innovation;insight;Interstitial Lung Diseases;Iron;Link;Lung;lung development;lung injury;Machine Learning;Macrophage;Measures;Mediating;member;metal complex;Metal exposure;metal poisoning;Metals;Minerals;Mining;Modeling;mouse model;Mus;nasopharyngeal swab;Navajo;neutrophil;New Mexico;novel;Outcome;Oxidative Stress;Particulate;Particulate Matter;Pathology;Pathway interactions;Physical condensation;Population;pre-clinical;programs;Pueblo Race;Pulmonary Inflammation;Research;research study;Respiration Disorders;response;Risk;Role;Route;Sampling;Silicon Dioxide;Silicosis;Site;Southwestern United States;Superfund;systemic autoimmunity;tool;Toxic effect;Translating;tribal community;tribal lands;Universities;Uranium;Vanadium;Work

PROJECT_TITLE: Inhaled Mine-Site Derived Metal Particulate Matter Drives Pulmonary and Systemic Immune Dysregulation


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE African American menthol cigarette smokers experience disproportionate tobacco-caused health burdens and have increased difficulty quitting smoking. Our novel examination of momentary predictors of smoking lapse will further our understanding of how to prevent smoking lapses and relapse among African American menthol smokers who try to quit smoking. These data can be used to inform high-impact, technology-supported observational studies and interventions aimed at mitigating tobacco-caused disparities among African Americans and menthol cigarette smokers.

PI_NAMEs: JONES, DINA MARIE (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Abstinence;Affect;African American;African American population;aged;Behavior Therapy;Behavioral trial;Biochemical;Black race;Carbon Monoxide;career;career development;Cessation of life;Cigarette;cigarette smoke;Cigarette Smoker;cigarette smoking;Competence;Consumption;contextual factors;Data;Dependence;Development Plans;Disparity;Ecological momentary assessment;efficacy testing;Electronic cigarette;electronic cigarette use;Ethnic Origin;Exhalation;experience;follow-up;Goals;Health;Health Disparities Research;Intervention;Interview;K-Series Research Career Programs;Literature;Malignant Neoplasms;Mediating;Menthol;Mentorship;mHealth;mobile application;Moods;Morbidity - disease rate;negative affect;Nicotine;nicotine craving;Nicotine Dependence;novel;Observational Study;Participant;perceived discrimination;perceived stress;positive mood;Predictive Factor;prevent;primary outcome;Race;Randomized;recruit;Relapse;Research;Research Personnel;Role;Science;Scientist;secondary outcome;Smoke;Smoker;Smoking;smoking cessation;Smoking Prevention;smoking relapse;Smoking Status;social disparities;statistics;success;summer institute;Surveys;Technology;Testing;Time;Tobacco;tobacco regulatory science;Training

PROJECT_TITLE: Predictors of Momentary Smoking Lapse Among African American Menthol Cigarette Smokers

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Biotechnology;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health

PHR: PROJECT NARRATIVE The co-occurrence of metal mixtures has been reported in natural geologic deposits and Superfund sites affected by mining legacy. The proposed research will contribute novel mechanistic insights that will enable the development of bioreactors catalyzed by plant-fungal symbiosis coupled with adsorption and precipitation using natural minerals for sustainable bioremediation of metal mixtures. The knowledge resulting from the proposed project is essential to risk assessment and to the advancement of bioremediation risk reduction strategies for metal mixtures.

PROJECT_TERMS: Adsorption;Advanced Development;Affect;Agriculture;aqueous;Area;Aridity;Arsenic;Award;Bacteria;Biological;Biological Assay;Biological Availability;Bioreactors;Bioremediations;Carbonates;chemical reaction;Chemicals;Chemistry;Collaborations;Communities;Community Developments;community partners;Complement;contaminated water;Coupled;Data;Deposition;Detection;Development;Ecology;Engineering;Ensure;Environment;Environmental Engineering technology;Experimental Designs;exposed human population;Exposure to;fungus;geochemistry;Goals;graduate student;Health;Human;Immobilization;innovation;inorganic phosphate;insight;interfacial;Knowledge;knowledge of results;Literature;Mediating;Metal exposure;metal poisoning;Metals;Minerals;Mining;Minority Groups;Molecular Biology;mycobiome;Navajo;next generation;novel;oxidation;Oxidation-Reduction;performance site;Phase;plant fungi;Plant Roots;Plants;Poaceae;Precipitation;programs;Property;Pueblo Race;remediation;Reporting;repository;Research;Risk;Risk Assessment;Risk Reduction;Role;Science;Scientist;Signal Recognition Particle;Site;Soil;Solid;Solubility;Southwestern United States;Stress;Superfund;superfund site;Surface;Symbiosis;System;Technology;Temperature;The science of Mycology;tool;toxic metal;Toxicity Tests;Toxicology;Training;tribal lands;underrepresented minority student;uptake;Uranium;Vanadium;Water;Work

PROJECT_TITLE: Bioremediation by integrating plant-fungi symbiosis and natural minerals for uptake of metal mixtures


NIH_SPENDING_CATS: American Indian or Alaska Native;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rural Health

PHR: NARRATIVE: METALS Administrative Core In Phase 2 of the UNM SRP Center [Metals Exposure and Toxicity Assessment on tribal Lands in the Southwest (METALS)] our Administrative Core will provide leadership to ensure our community-partnered approach drives the integrated team research focus of METALS. We will further enhance our translation to communities, tribal and national regulatory agencies and policy-makers, and clinicians to reduce risks. Through integrative partnering and comprehensive oversight of the Center, we will serve as a model and a nucleus for environmental health research within in our institution.

PI_NAMEs: LEWIS, JOHNNYE L (contact)

PROJECT_TERMS: Advisory Committees;Amendment;Area;Back;career development;Cell Nucleus;Clinical;clinical care;Collaborations;Communication;Communities;community engaged approach;community engaged research;community involvement;community partners;community partnership;COVID-19;COVID-19 impact;Data Analyses;data modeling;design;Development;Ensure;Environmental Health;evidence base;exposure pathway;Funding;Goals;Health education;Heart;Height;improved;indigenous community;Infrastructure;Institution;Institutional Management Teams;Institutional Review Boards;instrumentation;Intervention;Intervention Trial;Knowledge;Language;Leadership;Link;Localized Disease;Location;Logic;Metal exposure;metal poisoning;Modeling;Navajo;novel;pandemic disease;Phase;Policies;Policy Maker;Process;programs;Protocols documentation;Public Health;Pueblo Race;Research;Research Personnel;Resources;response;Risk Factors;Risk Reduction;Role;Safety;Sampling;Science;Scientist;Signal Recognition Particle;Social Work;Structure;success;Superfund;Thinking;Translating;Translational Research;Translations;trend;tribal lands;tribal leader;Tribes;Trust;Water;Work;Zinc

PROJECT_TITLE: Administrative Core


ORG_CITY: CAMDEN

ORG_NAME: RUTGERS THE STATE UNIV OF NJ CAMDEN

ORG_STATE: NJ

PHR: NARRATIVE The main goal of this research program is to elucidate the role of mammalian inorganic polyphosphate (polyP), an understudied molecule, in the stress response in mammalian cells. To accomplish this, using mammalian cellular models in which the levels of mitochondrial polyP will be modified, we will study the effects of polyP on the regulation of mammalian bioenergetics and mitochondrial physiology; and elucidate the signaling role of polyP in mammalian cells. Our findings will not only increase our knowledge of mitochondrial physiology, but they could also lead to the use of the metabolism of mitochondrial polyP as a valid and innovative pharmacological target in a wide-range of pathologies where mitochondrial dysfunction has been described, ranging from rare ophthalmological diseases to the most common neurodegenerative disorders.

PI_NAMEs: SOLESIO TORREGROSA, MARIA DE LA ENCARNACION  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acceleration;acute stress;Bacteria;Bibliography;Biochemical;Bioenergetics;biological adaptation to stress;Biological Assay;Calcium;Cell model;Cellular biology;Cellular Stress;Data;Disease;Evolution;Failure;Functional disorder;Goals;Homeostasis;human disease;innovation;Inositol;Knowledge;Laboratories;Location;Mammalian Cell;Methods;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;mitochondrial permeability transition pore;Molecular;Molecular Biology;Neurodegenerative Disorders;Organism;Pathologic;Pathology;pharmacologic;Physiology;Play;Polyphosphates;Process;programs;Protein Kinase;Regulation;Research;Role;Signal Transduction;Signaling Molecule;Stress;Techniques;Testing;therapeutic target;therapeutically effective;tool;Yeasts

PROJECT_TITLE: Mitochondrial inorganic polyphosphate in the mammalian stress response.


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Hookworm infection is a leading cause of anemia and malnutrition in developing countries, especially sub- Saharan Africa. Using human field samples and parasites cultivated in an animal model, we will conduct studies to define host immune responses to hookworm infection. The studies proposed here will provide novel insights that will aid the future development of effective monitoring and control strategies for human hookworm infection.

PI_NAMEs: CAPPELLO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: acquired immunity;Adult;Africa South of the Sahara;African;Albendazole;Allergens;Anemia;Animal Model;Animals;Antibodies;Antibody Response;Antigen Targeting;Antigens;Attention;Automobile Driving;benzimidazole;Biological Assay;Biology;Blinded;Blood;Child;Childhood;chronic infection;Collaborations;Communities;Country;Data;Demographic Factors;design;Developing Countries;Development;Diagnostic Procedure;Disease Surveillance;Dose;drug distribution;Drug resistance;Early Diagnosis;Effectiveness;Environment;Enzyme-Linked Immunosorbent Assay;Epidemiology;epidemiology study;Equipment;experience;experimental study;feeding;field study;Future;Generations;Genome;Ghana;global health;Goals;Growth;Hamsters;Health Policy;helminth infection;Helminths;high risk population;HIV;Hookworm Infections;Hookworms;Human;human data;Human Resources;human study;Immune response;Immunity;Immunoglobulin G;Immunoprecipitation;immunoreactivity;Impaired cognition;improved;in vivo Model;Individual;Infection;innovation;insight;Interruption;Intestines;Label;Laboratories;Laboratory Animal Models;low and middle-income countries;Malaria;Malnutrition;Measures;Mediating;Medical Research;Medicine;Methods;Microscopy;Modeling;molecular sequence database;Monitor;Morbidity - disease rate;Necator americanus;Nematoda;novel;Old World Hookworm;Parasites;Pathogenesis;Peptide Mapping;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Populations at Risk;Positioning Attribute;Predisposition;Pregnant Women;Prevalence;Productivity;programs;protein expression;Proteins;Proteomics;Public Health;Public Health Practice;Reagent;Recombinant Proteins;Recombinants;Recommendation;Research;Research Personnel;Resource-limited setting;response;risk prediction model;Role;Sampling;screening;secretory protein;Serology;Serum;Soil;Specificity;stool sample;Study Subject;Testing;Time;Tissues;tool;Training;transmission process;Tuberculosis;Universities;Vaccines;World Health Organization

PROJECT_TITLE: Defining serologic correlates of human hookworm infection

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]