ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: GEORGETOWN UNIVERSITY

PHR: Glioblastoma (GBM) is the most deadly of all brain tumors, and many patients die within one year of diagnosis. Our proposal will identify how the beta2 isoform of the nuclear receptor ESRRB, which is expressed at higher levels in longer-term GBM survivors, works as a potent inhibitor of GBM. These studies will provide powerful preclinical evidence for a future novel therapeutic strategy for GBM.

PI_NAMEs: RIGGINS, REBECCA B (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Actin-Binding Protein;Actins;Adjuvant;Affinity Chromatography;Agonist;Alternative Splicing;analog;antitumor effect;Apoptosis;Arginine;Behavior;Binding;Binding Sites;Biology;Blood - brain barrier anatomy;Brain;Brain Neoplasms;Cell Death;Cell Line;cell motility;Cells;Chemoresistance;Chemotherapy and/or radiation;Complement;Complex;Coupled;Cytoplasm;Data;Development;Diagnosis;Disease;EMS1 gene;Estrogen Nuclear Receptor;estrogen-related receptor;Estrogens;Event;Exons;experimental study;Fishes;Future;G2/M Arrest;Gene Dosage;Glioblastoma;Glioma;Grant;Growth;Human;In Vitro;in vivo;Induction of Apoptosis;inhibitor;Invaded;kinase inhibitor;knock-down;Label;late endosome;Link;Malignant Neoplasms;Mediating;Messenger RNA;Midbrain structure;Modeling;Molecular;Motility;Mus;non-invasive imaging;novel;novel strategies;novel therapeutic intervention;Nuclear Orphan Receptor;Operative Surgical Procedures;Outcome;overexpression;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Pigments;pre-clinical;Production;programs;Proliferating;Proline-Rich Domain;Protein Isoforms;Proteins;Radiation therapy;receptor;Reporter;RNA;RNA Splicing;Role;Serine;standard of care;stem cells;superresolution microscopy;Survivors;temozolomide;Testing;trafficking;Transcript;Transgenic Organisms;Treatment Protocols;treatment response;tumor growth;Up-Regulation;Vesicle;Work;xenoestrogen;Xenograft Model;Xenograft procedure;Zebrafish

PROJECT_TITLE: Novel functions of ESRRB in glioblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 TEHM-J (90)]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Newark

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Stiffening of the elastic arteries occurs during midlife and contributes to late life risk of Alzheimer's disease. Through this project, we will determine whether midlife arterial stiffness contributes to cognitive aging through an increase in cerebrovascular pulsatility and subsequent loss of brain tissue integrity. Overall, this project will identify the earliest mechanisms linking vascular aging to the loss of brain tissue integrity leading to new targets for interventions aimed at preventing age-related cognitive impairment.

PI_NAMEs: MARTENS, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: 4D MRI;abeta accumulation;Acceleration;Adult;Affect;age related;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease risk;Aorta;arterial stiffness;Arteries;Atrophic;Axon;Biological Markers;Blood flow;Blood Vessels;Brain;brain health;brain tissue;Cardiovascular system;Carotid Arteries;cerebrovascular;Cerebrovascular Circulation;cerebrovascular lesion;Clinical;cognitive ability;Cognitive aging;cognitive function;cognitive performance;Dementia;Development;Elasticity;Elderly;follow-up;Health;Hippocampus;Image;imaging modality;Impaired cognition;Impairment;Individual;interest;Intervention;late life;life span;Link;Liquid substance;longitudinal dataset;Longitudinal Studies;Magnetic Resonance Elastography;Measures;mechanical properties;Mediating;Mediation;Memory;Memory impairment;Memory Loss;middle age;middle cerebral artery;Modeling;neural;Neurodegenerative Disorders;Neuroglia;Neurons;non-invasive imaging;normal aging;older adult;Pathologic;Performance;Physiologic pulse;Pilot Projects;preservation;prevent;Prevention strategy;Property;Research;Structure;Testing;therapeutically effective;Time;Tissues;transmission process;United States National Institutes of Health;vascular cognitive impairment and dementia;Vascular Diseases;vascular risk factor;viscoelasticity

PROJECT_TITLE: Longitudinal impact of midlife cerebrovascular pulsatility on brain tissue integrity and cognitive aging

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Nanotechnology;Substance Misuse

ORG_CITY: BROOKLINE

ORG_NAME: FRAUNHOFER CENTER /MANUFACTURING INNOV

ORG_STATE: MA

PHR: Project Narrative The proposed work is focused on the advanced integration of HIV NAAT locked and stored in hydrogels and detected electrochemically with boron-doped diamond sensor microelectrode arrays. Each spot will individually readout amplification in what is essentially a novel, digital, electrochemical lateral flow assay. The successful completion of this project will deliver a demonstrator platform for the semi-quantitative readout of HIV viral loads at home.

PI_NAMEs: MCBETH, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Address;antibody test;aqueous;base;Biological;Biological Assay;Blood;Boron;Boston;Buffers;Charge;Clinic;Clinical Research;Cold Chains;Communicable Diseases;cost;Cytolysis;design;Detection;detection platform;Development;diabetes management;Diagnostic;diagnostic development;diagnostic platform;Diamond;digital;Electrochemistry;Encapsulated;Engineering;Environment;Enzymes;fabrication;FarGo;Fingers;flexibility;Fluorescence;Frustration;Gel;Goals;Healthcare;HIV;Home;home test;Human immunodeficiency virus test;Human Resources;Hydrogels;improved;Individual;Infection;Infrastructure;innovation;instrument;instrumentation;isothermal amplification;Laboratories;laboratory equipment;large scale production;Lateral;lateral flow assay;Leukocytes;manufacture;Marketing;materials science;meetings;Membrane;Microelectrodes;Molecular;Molecular Biology;nanosensors;novel;Nucleic Acid Amplification Tests;Nucleic Acids;Oils;pathogen;Persons;Phase;Plasma;point of care;Preparation;Printing;Proteins;Public Health;Reagent;Reporting;Research;Research Personnel;Reverse Transcriptase Polymerase Chain Reaction;Sampling;self testing;Sensitivity and Specificity;sensor;Specific qualifier value;Spottings;supply chain;Technology;Testing;Thinking;Training;transmission process;Universities;usability;Viral Genome;Viral Load result;virology;Virus;virus testing;Work

PROJECT_TITLE: Spatially multiplexed biogel nanosensors with boron-doped diamond microelectrode arrays for HIV self-testing

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JBS-A (S1)]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative: Gut dysbiosis in early childhood might cause or contribute to early-onset type 1 diabetes (T1D). Here we propose to develop and implement analytic methods to investigate temporal changes in gut microbiota in relation to the onset of islet autoimmunity and T1D using data from The Environmental Determinants of Diabetes in the Young (TEDDY) study. Our goal is to identify microbial biomarkers of islet autoimmunity and T1D, profoundly improving understanding of T1D etiology and potentially leading to the development of microbiome-based therapeutic strategies.

PI_NAMEs: HU, JIYUAN  (contact)

PROGRAM_OFFICER_NAME: AKOLKAR, BEENA

PROJECT_TERMS: analytical method;Appearance;Autoantibodies;Automobile Driving;Biological Markers;Birth;case control;Categories;Chronic;Clinical;cohort;Communities;Companions;Computer software;Data;Data Analyses;Developed Countries;Development;Diabetes Mellitus;diabetes risk;Disease;disease heterogeneity;early childhood;early onset;environmental change;Etiology;follow-up;Genetic Predisposition to Disease;Goals;Grouping;gut dysbiosis;gut microbiome;gut microbiota;high dimensionality;Immune;Immune system;improved;Incidence;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Investigation;islet autoimmunity;Joints;Life;Link;Measurement;Mediating;Metagenomics;Methods;microbial;microbiome;microbiome analysis;microbiome composition;microbiome research;microbiome therapeutics;Modeling;Monte Carlo Method;Nature;neglect;Nested Case-Control Study;Newborn Infant;novel;Pattern;Phase;Phenotype;pre-clinical;predictive marker;prevent;progression risk;Prospective Studies;Reporting;Research Design;Ribosomal RNA;Risk;risk prediction;Role;Sampling;secondary analysis;Shotguns;specific biomarkers;Statistical Methods;Susceptibility Gene;Taxonomy;Time;Time trend;tool;World War II

PROJECT_TITLE: Investigate the Role of Gut Microbiota in the Development of Type 1 Diabetes Using TEDDY Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-S (O2)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: STILLWATER

ORG_DEPT: PSYCHOLOGY

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: PROJECT NARRATIVE  Emerging and re-emerging respiratory viruses are a significant threat to public health and the global economy. While a dysregulated immune response is believed to cause acute lung injury and severe pneumonia following SARS-CoV-2 and other pathogenic human coronavirus infections, the basis for such deleterious host response is not well understood. Here, we will investigate the role of SARS-CoV-2 structural proteins/viral RNA and myeloid cell-intrinsic TLR-ERK1/2 activation in causing excessive lung inflammation and pathology and test the therapeutic potential of blocking ERK1/2 signaling in reducing lung pathology and providing improved protection.

PI_NAMEs: CHANNAPPANAVAR, RUDRAGOUDA  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: 2019-nCoV;Acute Lung Injury;Acute Respiratory Distress Syndrome;adaptive immunity;Adrenal Cortex Hormones;antagonist;Anti-viral Agents;Anti-viral Response;Anti-viral Therapy;antiviral immunity;Avian Influenza A Virus;CD8-Positive T-Lymphocytes;Cell Line;Cells;Clinical;Coronavirus;Coronavirus Infections;COVID-19;cytokine;Data;Defective Viruses;Dose;extracellular;FDA approved;Foundations;Human;human coronavirus;human model;Immune response;Immunity;Impairment;improved;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;Integration Host Factors;Interferons;Lung;lung injury;Lymphopenia;Macrophage;MAPK3 gene;Measures;Mediating;Mediator;Middle East Respiratory Syndrome Coronavirus;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Myelogenous;Myeloid Cells;Natural Immunity;neutrophil;novel;novel therapeutics;old mice;Outcome;pathogenic virus;Pathogenicity;Phosphotransferases;Pneumonia;Porcine Influenza A Virus;Production;Public Health;Publishing;Pulmonary Inflammation;Pulmonary Pathology;respiratory virus;response;Role;SARS coronavirus;SARS-CoV-2 infection;Severity of illness;Signal Transduction;single-cell RNA sequencing;Structural Protein;success;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic evaluation;TLR2 gene;Toll-like receptors;Treatment Efficacy;Viral;Viral load measurement;Viral Proteins;viral RNA;Virus;Work

PROJECT_TITLE: Role of ERK1/2 signaling in SARS-CoV-2 -induced dysregulated immunity and lung pathology.

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Brain Disorders;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Hepatic encephalopathy (HE) is a serious complication of chronic liver diseases, observed in nearly 70% of patients with cirrhosis and is one of the most common reasons for hospitalization and increased mortality rates in these patients. With the rising costs associated with managing HE and the lack of effective treatment options, gaining an understanding of the mechanisms that cause HE can potentially lead to therapeutic interventions to help improve the outcome of patients with this syndrome. This proposal investigates how changes in brain cholesterol, which occurs in other neurological disorders, can influence HE with the aim to target cholesterol as a potential therapeutic option.

PI_NAMEs: DEMORROW, SHARON  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Acute Liver Failure;Adult;Alcoholic Liver Diseases;Allopregnanolone;Alzheimer's Disease;Binding;Brain;brain dysfunction;Brain Pathology;Catabolism;Cell membrane;Cerebral Edema;Cessation of life;Cholesterol;Cholesterol Homeostasis;chronic liver disease;Cicatrix;Cirrhosis;Clinical;clinical prognosis;Complication;cost;Data;Death Rate;design;Development;Diagnosis;drug development;effective therapy;Esterification;Event;experimental study;gene repression;Goals;Health Expenditures;Healthcare Systems;Hepatic Encephalopathy;Hepatitis B;Hepatitis C;Hospitalization;Impairment;improved;improved outcome;In Vitro;in vivo;Knowledge;Liver;Liver Cirrhosis;Liver diseases;liver function;liver injury;Mediating;Membrane;Membrane Fluidity;Metabolism;Mitochondria;Modeling;Molecular;molecular pathology;Morbidity - disease rate;mortality;mouse model;Nervous System Disorder;neural;neurobehavioral;neuroinflammation;Neurologic;Neurologic Deficit;Neurologic Dysfunctions;neurosteroids;neurotransmission;new therapeutic target;non-alcoholic fatty liver disease;novel;novel therapeutic intervention;Outcome;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Pick Disease of the Brain;Pregnenolone;Prognosis;programs;Quality of life;receptor;Receptor Activation;Receptor Signaling;receptor-mediated signaling;Research;Resolution;Rodent Model;Role;symptom management;Syndrome;Testing;Therapeutic;Therapeutic Intervention;Tissues;Transgenic Mice;treatment strategy;United States National Center for Health Statistics;Up-Regulation;Virus Diseases

PROJECT_TITLE: Role of cholesterol in the pathogenesis of hepatic encephalopathy

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Opioid Misuse and Addiction;Opioids;Precision Medicine;Rehabilitation;Sleep Research;Social Determinants of Health;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative The proposed research is relevant for public health as it develops and tests a novel method to improve the sleep of individuals with opioid use disorder through a health equity lens. The overdose epidemic is a national problem, and the majority of individuals in treatment for opioid use disorder also have insomnia. The goal of this project is to develop and test a brief behavioral treatment for insomnia in persons with opioid use disorder and to determine if this novel treatment also helps individuals abstain from substance use in addition to improving their sleep.

PI_NAMEs: MARTIN, CAITLIN EILEEN (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: addiction;Address;Adherence;Adult;Aftercare;Behavior;Behavior Therapy;biopsychosocial;Black race;Buprenorphine;Caring;Cause of Death;Cells;Child Care;Clinical Trials;Cognitive Therapy;combat;Communities;community partners;Comorbid Insomnia;comorbidity;COVID-19 pandemic;craving;Data;Decision Aid;Development;disparities in morbidity;Education;Effectiveness;Environment;Epidemic;Ethnic Origin;evidence base;experience;Face;Feedback;follow-up;Gender;Goals;Health;health equity;health equity promotion;Impairment;improved;improvement on sleep;Impulsivity;indexing;Individual;individualized medicine;interdisciplinary approach;interest;Internet;Intervention;intervention refinement;Iran;Learning;Life;Lived experience;medication for opioid use disorder;men;Methadone;Methods;Modality;mortality;National Institute of Drug Abuse;novel;opioid use;opioid use disorder;optimal treatments;Outcome;Overdose;Overdose reduction;overdose risk;Pain;Participant;Pathway interactions;patient population;Patients;personalized approach;personalized medicine;Persons;Pharmaceutical Preparations;Phase;pilot test;Play;Population;post-pandemic;Poverty;precision medicine;preference;primary outcome;Public Health;Publishing;Quality of life;Race;Randomized;Reaction;Recovery;recruit;Recurrence;Relapse;Reporting;Research;Risk;Route;Sampling;Schedule;secondary outcome;Services;Severities;sex;Sleep;Sleep Disorders;sleep health;Sleeplessness;social health determinants;Social support;standard care;Stress;substance use;telehealth;Testing;Trauma;treatment as usual;Treatment outcome;United States;Woman;Work

PROJECT_TITLE: Health equity informed delivery of cognitive behavioral therapy for insomnia adapted for individuals with opioid use disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Type 1 Diabetes (T1D) affects 8.7 million people globally and 1.6 million in the US, and as many as 4-5 million Americans are at risk of developing T1D. T1D results in destruction of beta cells and loss of insulin, prompting an urgent need for regeneration and replacement of fully mature, functional beta cells. Here, I am developing unique genetic tools to elucidate the final crucial steps in human beta cell differentiation, understanding that will allow both generation of fully functional replacement human beta cells, and also identification of druggable targets for beta cell regeneration, highly required for treatment of people with T1D.

PI_NAMEs: BEVACQUA, ROMINA  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Adolescent;Adult;Affect;Age;age related;American;ATAC-seq;Autoimmune Diseases;Automobile Driving;B-Lymphocytes;Beta Cell;Biological Assay;Blood Glucose;Blood Vessels;Cell Differentiation process;Cell Maturation;Cell Physiology;cell regeneration;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Complex;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;druggable target;Electroporation;Elements;Enhancers;Evaluation;Gene Activation;Gene Expression;Generations;Genes;Genetic;Genetic Enhancer Element;genetic manipulation;Genetic Transcription;Glucose;Goals;Human;human stem cell-derived;Hypoglycemia;Impairment;indexing;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;Islet Cell;knock-down;Knowledge;Link;macrovascular disease;manufacture;Measures;Mus;Natural regeneration;new technology;novel;Pathway interactions;Persons;Postdoctoral Fellow;prevent;promoter;Regenerative Medicine;Regulatory Element;Ribonucleoproteins;Risk;Role;RXRG gene;Scheme;small hairpin RNA;Source;standard care;stem cells;Structure of beta Cell of islet;System;Therapeutic;tool;transcription factor;transcriptome sequencing;Untranslated RNA

PROJECT_TITLE: Identification of Novel Regulatory Mechanisms Driving Human beta-Cell Maturation and Function.


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Endocrine Disruptors;Mental Health;Mental Illness;Neurosciences

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Environmental exposures may be important in the etiopathogenesis of psychiatric diseases involving reward processing deficits. This proposal examines the role that per- and polyfluoroalkyl substances (PFAS) may have in psychiatric risk, especially for an anhedonia phenotype with relevance to depression. Given widespread exposure to PFAS (detectable in most human blood), it is critical to examine whether and how exposures may influence the risk of neurological disease and to determine whether those with high PFAS levels should be monitored for heightened reward processing deficits.

PI_NAMEs: CANNON, JASON R (contact);FOTI, DANIEL JUSTIN

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Adult;aged;Amphibia;Anhedonia;animal data;Animal Experiments;Animal Model;Animals;Area;Behavioral;behavioral phenotyping;Biochemical;Blood;Brain;Brain region;brain tissue;Clinical;clinical phenotype;clinical translation;clinically relevant;Communities;Cross-Sectional Studies;Data;data modeling;depressive symptoms;Development;developmental neurotoxicity;Developmental Toxicant;Disease;Dose;early life exposure;Environment;Environmental Exposure;Environmental Pollutants;Etiology;Experimental Designs;Exposure to;flexibility;follow-up;Foundations;Future;Health;Human;human data;human study;Indiana;Individual;innovation;Laboratories;Laboratory Animals;Laboratory mice;Life;Light;Link;Literature;Longitudinal Studies;Major Depressive Disorder;Manic;Measurement;Measures;Mediating;Mental Depression;Mental disorders;Modeling;Molecular;Monitor;mouse model;Mus;Nematoda;Nervous System Disorder;neural;neurobehavioral;neurochemistry;Neurologic;neuropathology;neurophysiology;neuropsychiatric disorder;neurotoxic;neurotoxicity;neurotransmission;Neurotransmitters;Onset of illness;Outcome;Patient Self-Report;Phenotype;Poly-fluoroalkyl substances;psychiatric symptom;Psychoses;Public Health;Publishing;Recording of previous events;Regimen;Research;reward processing;Rewards;Risk;Role;Sampling;Sentinel;Serum;Severities;Specificity;stem;System;Testing;Time;translational approach;Translations;Ventral Striatum;Weaning;Wild Animals

PROJECT_TITLE: PFAS induced alterations in reward processing

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Neurosciences

ORG_CITY: EAU CLAIRE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN EAU CLAIRE

ORG_STATE: WI

PHR: Public Health Relevance Statement The field of neuroscience and regenerative sciences needs ongoing innovation to address the challenges of understanding brain function and brain-related disorders. The University of Wisconsin Eau Claire – Mayo Clinic Regenerative Neuroscience Scholars (ReNS) Program enables undergraduates to obtain high-quality training in regenerative neuroscience research. Using innovative and coordinated approaches in recruitment, research, curriculum, and mentoring, this program will prepare students for success in careers in research and Ph.D. training in neuroscience and regenerative sciences.

PI_NAMEs: CARTER, BRADLEY S (contact);SCARISBRICK, ISOBEL A

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Advisory Committees;Agreement;American;Biomedical Research;Brain;bridge program;Capital;career;career development;career networking;Clinic;cohort;Color;Critical Thinking;Data Analyses;Dedications;design;Development;disabled students;Disease;Diverse Workforce;Doctor of Philosophy;Educational Curriculum;educationally disadvantaged;Employment;experience;Experimental Designs;Faculty;faculty mentor;faculty support;Feedback;Fellowship Program;Goals;graduate school;graduate student;innovation;Institution;interest;Interview;Laboratories;Laboratory Research;Learning;Letters;member;Mentors;minority student;Neurosciences;Neurosciences Research;Oral;Participant;peer;peer coaching;Postbaccalaureate;posters;Productivity;programs;prospective;Publications;Recommendation;recruit;regenerative;Relationship-Building;Reproducibility;Research;research and development;Research Personnel;Research Training;role model;Scholars Program;Science;Scientist;Self Efficacy;skill acquisition;skills;skills training;social;socioeconomic disadvantage;STEM career;Structure;Students;success;summer research;symposium;Thinking;Training;Training Programs;Training Support;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Students;Universities;Videoconferencing;Wisconsin;Work;Writing

PROJECT_TITLE: University of Wisconsin Eau Claire-Mayo Clinic Regenerative Neuroscience Scholars (ReNS) Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-D (27)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative: The Carolina Summer Fellowship Program (CSFP) at UNC has helped several undergraduate students from underrepresented (UR) backgrounds matriculate into careers in research. To address the disparity in representation in neuroscience research careers, we propose the CSFP-Neuro program, which utilizes our well-established summer research infrastructure to increase the number of UR individuals in neuroscience research. By providing top-level summer research experiences in the neurobiology of disease by trained mentors, coupled with career mentoring and professional development that continues beyond the summer, students will be well prepared for successful careers in neuroscience research.

PI_NAMEs: COLEMAN, LEON GARLAND;PHILPOT, BENJAMIN D;SCHISLER, JONATHAN C. (contact)

PROJECT_TERMS: Academia;Academy;Address;Admission activity;aluminum sulfate;Area;career;Career Choice;career development;CCL7 gene;cohort;college;Communication;Communities;Complex;Coupled;design;Development;Disease;Disparity;Doctor of Medicine;Doctor of Philosophy;Education;educational atmosphere;Educational Status;Educational workshop;Enrollment;Environment;Equity;Ethnic Population;evidence base;experience;Faculty;falls;Fellowship Program;Fostering;Funding;Goals;graduate school;graduate school preparation;Health Sciences;Historically Black Colleges and Universities;implicit bias;Individual;interest;Journals;Laboratories;Leadership;Learning;matriculation;Medical;member;Mentors;Mentorship;Minority-Serving Institution;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurobiology;Neuropharmacology;Neurosciences;Neurosciences Research;North Carolina;Oral;peer;Pharmacology;Population;Population Heterogeneity;posters;Program Development;programs;prospective;racial population;recruit;Research;research and development;Research Infrastructure;Research Methodology;Research Project Grants;Research Training;responsible research conduct;Running;Scholars Program;Science;Scientist;skills;Statistical Methods;STEM career;Structure;student participation;student retention;Students;success;summer research;support network;symposium;Time;tool;Training;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities;virtual;Writing

PROJECT_TITLE: CAROLINA SUMMER FELLOWS PROGRAM IN NEUROPHARMACOLOGY AND NEUROBIOLOGICAL DISEASES (CSF-NEURO)


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Nanotechnology;Women's Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: This project is aimed at developing safe and effective smart lipid siRNA nanoparticles to regulate long noncoding RNAs (lncRNAs) associated with cancer metastasis and drug-resistance in triple-negative breast cancer patients. Tumor- specific silencing of cancer-promoting lncRNAs with the nanoparticles offers a novel therapy to treat invasive breast cancer with minimal side-effects, to enhance the efficacy of chemotherapy and/or immunotherapy, and to eventually eradicate the disease and improve the survival of cancer patients.

PI_NAMEs: LU, ZHENG-RONG  (contact);SCHIEMANN, WILLIAM

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Affect;aggressive breast cancer;amphiphilicity;Animal Model;Animals;Antineoplastic Agents;Biological Process;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;cancer drug resistance;Cancer Patient;cancer subtypes;cancer survival;cancer therapy;Cells;Cessation of life;chemotherapy;Chemotherapy and/or radiation;Circulation;Code;Combined Modality Therapy;curative treatments;Cytoplasm;Death Rate;Development;Disease;Down-Regulation;Drug resistance;Drug Targeting;effective therapy;efficacious treatment;efficacy evaluation;endosome membrane;Endosomes;Engineering;Epidermal Growth Factor Receptor;Epigenetic Process;Estrogen Receptors;Exhibits;Gene Expression Regulation;Gene Silencing;Genes;Genetic;Genetic Transcription;Goals;Growth;Hormones;Human;Immune;Immunocompetent;Immunocompromised Host;Immunosuppression;Immunotherapy;improved;ineffective therapies;innovation;Invaded;ionization;Life;Lipids;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Metastatic/Recurrent;Modeling;Multi-Drug Resistance;Mus;nanoparticle;Neoplasm Metastasis;Normal tissue morphology;novel;novel therapeutics;Nucleotides;Oncogenic;Outcome;overexpression;Patients;peptide drug;Phenotype;Physiological;Play;pre-clinical;pre-clinical assessment;prevent;Progesterone Receptors;Proliferating;prototype;Radiation therapy;Refractory;Regimen;Relapse;Resistance development;RNA;Role;side effect;Signal Pathway;Small Interfering RNA;standard of care;Survival Rate;targeted delivery;targeted treatment;Therapeutic;therapeutic siRNA;therapeutic target;therapy outcome;Time;Transcript;transcriptome sequencing;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;Tumor Specific Peptide;tumorigenesis;Untranslated RNA;women's diagnosis

PROJECT_TITLE: Smart nanoparticles regulating oncogenic IncRNA for breast cancer therapy

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative: Elimination of glucagon receptor signaling shortens lifespan and healthspan in mice. Preliminary data presented in this proposal suggests that increasing glucagon signaling can improve metabolic and physical function in aging mice. Herein, we propose to extend these preliminary findings to investigate the potential to enhance glucagon signaling to extend healthspan and lifespan.

PI_NAMEs: STERN, JENNIFER HELENE (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: 5'-AMP-activated protein kinase;adenovirus mediated delivery;Adenylate Cyclase;adenylate kinase;Affect;age acceleration;age-related disease;Aging;aging mechanism;Agonist;Behavior Therapy;blood glucose regulation;Caloric Restriction;Cells;cerebrovascular;Chronic;Clinic;Cognitive;cognitive function;constitutive expression;Cyclic AMP;Data;detection of nutrient;Development;Diabetes Mellitus;Diet;diet-induced obesity;dietary;Energy Metabolism;extend lifespan;gene therapy;Genetic;Genetic Models;Glucagon;Glucagon Receptor;glucagon-like peptide 1;hallmarks of aging;healthspan;Hepatic;Hepatocyte;High Fat Diet;Hormones;hyperglucagonemia;Impairment;improved;Insulin;insulin signaling;Intervention;Knock-out;Knockout Mice;life span;Liver;Longevity;Marketing;Mediator;Metabolic;Mitochondria;Modeling;Molecular;Mus;mutant;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;normal aging;Obese Mice;Obesity;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Physical Function;Play;prevent;proteostasis;Receptor Activation;Receptor Signaling;Research;Research Personnel;Rodent;Role;senescence;Serum;Signal Pathway;Signal Transduction;Skeletal Muscle;Telomere Shortening;Therapeutic;Thinness;Tissues;Translating;treatment response;Type 2 diabetic;Weight;Wild Type Mouse;Work

PROJECT_TITLE: Investigating the Role of Hepatic Glucagon Receptor Signaling in Healthspan and Aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE The goal of this proposal is to develop a new approach to inhibit androgen receptor (AR) activity and stop the growth of prostate cancer cells that have developed resistance to standard anti-androgen agents using peptoid conjugates that potently inhibit AR activity while simultaneously eliciting an innate immune response that can be leveraged to induce immune cell killing of the drug-resistant tumor. By combining the development of peptoid conjugates that inhibit AR activity with an investigation of their potential to elicit an immune response that can be leveraged for tumor killing, our research has the potential to make significant contributions to prostate cancer treatment.

PI_NAMEs: GARABEDIAN, MICHAEL J. (contact);KIRSHENBAUM, KENT W

PROJECT_TERMS: advanced prostate cancer;Affect;Affinity;Aftercare;Androgen Antagonists;androgen independent prostate cancer;Androgen Receptor;antagonist;anti-tumor immune response;Antibodies;Antitumor Response;appendage;Binding;cancer recurrence;cell killing;Cell Proliferation;cell type;Cells;Characteristics;ChIP-seq;cofactor;Complementary therapies;Cytotoxic T-Lymphocytes;Data;design;Development;DNA;DNA receptor;Dose;drug development;Drug resistance;drug resistance development;effective therapy;efficacy testing;Ensure;enzalutamide;Exhibits;Family;fighting;Future;Gene Expression;Genes;Genetic Transcription;Genomics;Goals;Growth;Half-Life;human disease;Immune;immune cell infiltrate;immune checkpoint blockade;Immune response;Immune system;Immunotherapy;improved;in vivo;in vivo evaluation;inhibitor;Innate Immune Response;innovation;insight;Investigation;Ligand Binding;Ligands;Malignant neoplasm of prostate;Mediating;Mitosis;Modeling;Molecular Conformation;Mus;Mutation;nanomolar;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Organoids;Pathway interactions;Patients;Pattern;Peptide Hydrolases;peptidomimetics;Peptoids;Permeability;pharmacologic;Pharmacology;polypeptide;Proliferating;Property;prostate cancer cell;Prostate Cancer therapy;Prostatic Neoplasms;Proteins;Publishing;receptor;recruit;Research;Resistance;Resistance development;response;scaffold;Site;Solubility;standard care;synergism;T cell response;Testing;Therapeutic;Therapeutic Agents;Transcript;transcriptome sequencing;tumor;tumor growth;Tumor Immunity;tumor-immune system interactions;Variant;X-Ray Crystallography;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Peptoid conjugates targeting prostate cancer

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Our understanding of the connection between housing relocation interventions and mental health remains limited by a lack of high-quality studies assessing projects with effective implementation strategies. Our proposal integrates and addresses these needs, linking geographic and psychological expertise with established community partnerships to study the impact of such an intervention on a discrete sub-population of residents in Flint, Michigan, via a longitudinal assessment of the natural experiment.

PI_NAMEs: BEATTY MOODY, DANIELLE LATHEL (contact);SADLER, RICHARD CASEY

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Acceleration;Address;Advocacy;Affective;African American;African American population;Age;age acceleration;age related;age related changes;Aging;aging related;aging related disease;archived data;Baltimore;Behavioral;behavioral health;biological sex;biopsychosocial;Black Populations;Black race;built environment;Calendar;Cardiometabolic Disease;cardiometabolic risk;Characteristics;Cities;Cognitive aging;cognitive function;cohort;Cohort Studies;Communities;community partnership;Complement;Data;Data Set;Development;Disadvantaged;Discrimination;Disease;disorder risk;early onset;Environment;Epidemiology;Equation;Exposure to;follow-up;frailty;functional decline;Future;Geographic Information Systems;Geography;Goals;Health;health disparity;health equity;health inequalities;healthy aging;Housing;Impaired cognition;implementation strategy;Intervention;Interview;Investigation;Knowledge;Legal;Life;Life Cycle Stages;life span;Link;Maps;Maryland;Measurement;Measures;Mediating;men;Mental Depression;Mental Health;Michigan;middle age;Modeling;Modification;Natural experiment;negative affect;Neighborhoods;Outcome;Participant;Pathway interactions;Pattern;Perception;Persons;Physical Function;Policies;Process;prospective;psychologic;Race;racial disparity;rate of aging;Recording of previous events;Research;residential segregation;resilience;Risk;Risk Factors;Role;Sampling;Self Assessment;sex;Shapes;Smoking;social capital;Social Environment;Socioeconomic Status;socioeconomics;Structural Racism;System;Time;United States National Institutes of Health;Variant;virtual;Woman;Work

PROJECT_TITLE: Examining Influences of Place-Based Historical and Contemporary Structural Racism on Racial Disparities in Aging-Related Disease Risk Trajectories: Leveraging the HANDLS Dataset

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Genetics;Kidney Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Acute kidney injury (AKI) remains a very important and growing global unmet need with lack of effective therapies. In addition to the adverse effects on patient morbidity and mortality associated with AKI it has long term consequences, leading to chronic kidney disease. Our goal is to understand the mechanisms of kidney injury and repair to be able to develop therapies for patients.

PI_NAMEs: BONVENTRE, JOSEPH VINCENT (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Acceleration;Acute;Acute Renal Failure with Renal Papillary Necrosis;Adverse effects;age acceleration;aged;Aging;Animals;apoAI regulatory protein-1;ATR gene;Autophagocytosis;Breast Cancer Cell;Bromodomain;Cell Aging;Cell Cycle;Cell Cycle Arrest;Cell Death;Cell Death Inhibition;cell injury;Cells;Cessation of life;chemokine;Chemosensitization;Chronic;Chronic Kidney Failure;Clinical;Complement;Complement Inactivators;Coupled;DNA Damage;DNA Repair;Down-Regulation;effective therapy;Epigenetic Process;epigenome;Epithelial Cells;Erinaceidae;Excision;Family;fatty acid oxidation;Female;Fibroblasts;Fibrosis;Functional disorder;Generations;Genetic;Glycolysis;Goals;Grant;Growth Factor;Human;human pluripotent stem cell;Impairment;in vivo;indexing;ineffective therapies;Inflammatory;Injury;injury and repair;Injury to Kidney;interstitial;Ischemia;ischemic injury;Kidney;kidney cell;kidney epithelial cell;kidney repair;knock-down;knockout animal;Knockout Mice;Lamin Type A;male;Malignant Breast Neoplasm;Mediator;member;Metabolism;Modeling;Modification;Morbidity - disease rate;mortality;mouse model;Mus;Myofibroblast;Nephrology;novel;Nuclear;Nuclear Lamin;Operative Surgical Procedures;Organoids;Pathway interactions;Patients;Pericytes;Persons;Phenotype;Predisposition;prelamin A;Prevention strategy;Process;Production;protein activation;Proteins;Proximal Kidney Tubules;Publications;renal ischemia;repaired;replication stress;response;response to injury;Rodent;Role;senescence;senescence associated secretory phenotype;Sirolimus;spheroids;stem cell population;System;Therapeutic;therapy development;Tissues;Transgenic Mice;Transgenic Organisms;Urology;Wild Type Mouse;Work

PROJECT_TITLE: Mechanisms of Ischemic Kidney Injury and Repair

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Orphan Drug;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE Dilated cardiomyopathy (DCM) is a prevalent cause of heart failure and death. Many cases of DCM have a well-defined genetic basis, and this genetic knowledge holds great promise for developing mechanism-based treatments to halt or revert disease progression. Using models of inherited DCM, we identified a set of candidate therapeutic genes, and this renewal application will investigate their potential utility as drug targets using human in vitro models, human population genetics, and a mouse in vivo model of DCM.

PI_NAMEs: MERCOLA, MARK  (contact);SUBRAMANIAM, SHANKAR

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Affect;Age Months;Animal Model;Biochemical;biological adaptation to stress;Candidate Disease Gene;cardiac magnetic resonance imaging;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Cessation of life;Clinical;CRISPR correction;Data;Development;Dilatation - action;Dilated Cardiomyopathy;Disease;Disease Progression;DNA Sequence Alteration;Drug Targeting;Echocardiography;EFRAC;endoplasmic reticulum stress;Engineering;familial dilated cardiomyopathy;Fibrosis;Functional disorder;functional genomics;functional restoration;Funding;gene discovery;Gene Mutation;Genes;Genetic;genetic variant;genome wide association study;genomic tools;Goals;Heart;Heart failure;heart function;Human;human disease;Human Genetics;human induced pluripotent stem cells;human population genetics;improved;in vitro Model;in vivo;in vivo Model;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Infection;knock-down;Knock-in Mouse;Knowledge;Lead;Link;Mediating;Messenger RNA;Metabolic;Metabolic Pathway;Microfilaments;MicroRNAs;Mitochondria;Modeling;Molecular;Molecular Genetics;molecular marker;Morbidity - disease rate;mortality;Mus;Muscle Proteins;mutant;Mutation;Myocardium;network models;new therapeutic target;Pathway interactions;Patients;Persons;Physiological;Physiological Processes;Process;Proteins;restoration;screening;small hairpin RNA;Small Interfering RNA;sudden cardiac death;Symptoms;Systems Biology;Testing;Therapeutic;therapeutic candidate;therapeutic gene;Therapeutic Intervention;therapeutic target;trait;Translating;Translations;Treatment Efficacy;Variant;vector

PROJECT_TITLE: MicroRNA Control of Dilated Cardiomyopathy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE We previously identified dual leucine zipper kinase (DLK) and leucine zipper kinase (LZK) as promising neuroprotective targets in retinal ganglion cell (RGC) degenerations/optic neuropathies like glaucoma. More recently, we have used chemical genetic and clustered regularly interspaced short palindromic repeat (CRISPR)-based screens in RGCs to identify a set of sterile 20 (STE20) kinases that regulate DLK/LZK. In this proposal, we explore novel mechanisms by which STE20 kinases regulate this key neuronal injury pathway and exploit this knowledge to develop robust neuroprotective and neuroregenerative strategies that we then test in rodent models of glaucoma.

PI_NAMEs: WELSBIE, DEREK STUART (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Affect;Amino Acids;Axon;axon injury;axon regeneration;axonal degeneration;Axotomy;Biological Assay;Blindness;Cancer Biology;cancer cell;Cauterize;Cell Death;cell injury;Cell Survival;Cessation of life;chemical genetics;Chemosensitization;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complement;Cytoprotection;Data;Dependovirus;design;Development;Distal;Family;functional genomics;Funding;gain of function;Genetic Screening;Genetic Transcription;germinal center kinases;Glaucoma;Growth;Human;human stem cell-derived;improved;Individual;Injury;insight;interest;jun Oncogene;Knock-out;Knowledge;Lasers;LATS1 gene;LATS2 gene;Leucine Zippers;Link;loss of function;MAP Kinase Kinase Kinase;MAP4K4 gene;Mediating;Modeling;Molecular;Molecular Probes;Mus;mutant;N-terminal;Nerve Crush;Nerve Degeneration;Nerve Regeneration;Neurodegenerative Disorders;Neuronal Injury;Neurons;neuroprotection;nonhuman primate;novel;Optic Disk;Optic Nerve;optic nerve disorder;outcome disparities;paralogous gene;Pathway interactions;Patients;Phenocopy;Phosphorylation;Phosphotransferases;Physiologic Intraocular Pressure;preservation;pressure;prevent;Process;PTEN gene;Rattus;Reagent;regenerative;regenerative approach;Regulation;retinal ganglion cell degeneration;Retinal Ganglion Cells;Rodent Model;Role;screening;sight restoration;Signal Transduction;small molecule inhibitor;Sterility;Subgroup;synergism;Testing;Therapeutic;transcription factor;Transcriptional Coactivator with PDZ-Binding Motif;transcriptome sequencing;transcriptomics;Tumor Suppressor Proteins;Veins

PROJECT_TITLE: Kinase Multitargeting for Glaucoma Neuroprotection

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative With nearly 6 million Americans live with heart failure (HF) with 670,00+ cases added each year, HF is a relentlessly progressive disease that is associated with an unacceptably high death rate. SERCA2a, SDF-1, and AC6 have been tested in randomized clinical trials showing no significant efficacy, calling for the identification and characterization of a new molecular target of HF therapeutics. Based on the extensive preliminary studies, we here propose that fortilin, abundantly expressed in the heart, is an excellent molecular target of HF therapeutics and test the hypothesis using molecular, cellular, whole-animal methods.

PI_NAMEs: FUJISE, KEN  (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Adenylate Cyclase;Age;alphaT catenin;American;Amino Acids;Animals;Apoptotic;Applications Grants;Autopsy;Binding;Biological Assay;Birth;Blood capillaries;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cell Nucleus;Cell Physiology;Cells;Complementary DNA;Coronary Arteriosclerosis;Cytosol;Death Rate;Dependovirus;Development;Diagnosis;differential expression;Echocardiography;Enterobacteria phage P1 Cre recombinase;Fibrosis;Functional disorder;GATA4 gene;Genes;Genetic;Genetic Complementation Test;Genetic Transcription;Goals;Heart;Heart failure;Human;Hypertension;Immunoprecipitation;Intercalated disc;Interferometry;Intraperitoneal Injections;Ischemia;ischemic cardiomyopathy;Knock-out;Knockout Mice;Left;Ligation;LoxP-flanked allele;Luciferases;MCL1 gene;Mediating;Messenger RNA;Methods;Microarray Analysis;Molecular;Molecular Analysis;Molecular Target;multicatalytic endopeptidase complex;Mus;Myocardial;myocyte-specific enhancer-binding-factor 2C;overexpression;Patients;Phenotype;pressure;prevent;Progressive Disease;promoter;protein degradation;protein expression;Proteins;randomized, clinical trials;Recombinant adeno-associated virus (rAAV);Resistance;Rhesus;RNA;Role;Sampling;Sarcomeres;sarcoplasmic reticulum calcium ATPase;Satellite Viruses;SERCA2a;Serotyping;small hairpin RNA;sound;Stromal Cell-Derived Factor 1;Structure;Testing;Therapeutic;TPT1 gene;Transcript;transcription factor;Transgenic Mice;Transgenic Organisms;Transmission Electron Microscopy;Ventricular;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Fortilin, CTNNA3, and the Heart

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: NARRATIVE This research addresses our recent discovery revealing that pancreatic beta cells have an unusual glycomic profile relatively deficient in the expression of sialic acids. Supporting data reveal that mice bearing augmented expression of immune tolerogenic sialic acids among pancreatic beta cells are protected from insulitis, hyperglycemia, and the immunological destruction in a mouse model of Type 1 diabetes. This proposal will investigate these findings that may explain the susceptibility of pancreatic beta cells to immune attack in triggering autoimmune disease and how to inhibit this disease process.

PI_NAMEs: MARTH, JAMEY  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Adaptive Immune System;Address;Adoptive Transfer;anergy;Animal Model;anomer;Apoptosis;Asparagine;Autoantibodies;Autoimmune Diabetes;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;B-Lymphocytes;Beta Cell;Binding;Cell surface;cell type;Cells;Coculture Techniques;Complex;cytokine;Cytoprotection;Data;Defect;Development;Diabetes Mellitus;diabetic;Discrimination;Disease;Distal;Family;Frequencies;Genes;Glycoproteins;glycosyltransferase;Health;Human;human model;Hyperactivity;Hyperglycemia;Immune;immune activation;immune cell infiltrate;Immune mediated destruction;Immune signaling;Immune system;Immune Tolerance;Immunologic Receptors;Immunologics;Inbred NOD Mice;Innate Immune System;insight;Insulin;Insulin deficiency;Insulin-Dependent Diabetes Mellitus;insulitis;Intervention;islet;Islet Cell;Islets of Langerhans Transplantation;Knowledge;Laboratory Research;Leucocytic infiltrate;Leukocytes;Ligands;Link;lupus-like;Lymphocyte;Mammalian Cell;Measures;Membrane Glycoproteins;Molecular;mouse model;Mouse Strains;Mus;Non obese;Onset of illness;Outcome;Pancreas;Polysaccharides;Positioning Attribute;Post-Translational Protein Processing;Predisposition;Process;promoter;Rattus;receptor;Receptor Cell;Research;Research Proposals;RNA;Role;Self Tolerance;sialic acid binding Ig-like lectin;Sialic Acids;sialylation;Sialyltransferases;Structure of beta Cell of islet;T-Lymphocyte;Tissues;transgene expression;Transgenes;Transgenic Organisms;Transplantation

PROJECT_TITLE: Glycosyltransferase Function in Development and Disease

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: OMAHA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Our proposed studies aim to understand the cellular communication in the heart and the cross-talk between the heart and brain in heart failure to further our understanding sympathetic nerve activity regulation in heart failure. We will elucidate a novel Extracellular vesicle-mediated communication pathway that is important for oxidative damage in both the heart and the brain in heart failure. Novel techniques will be applied for the first time to this pathway.

PI_NAMEs: TIAN, CHANGHAI ;ZUCKER, IRVING H (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Animals;Anti-Inflammatory Agents;antioxidant enzyme;Antioxidants;Area;Attenuated;blood-brain barrier crossing;Brain;Cardiac;Cardiovascular system;Cells;Central Nervous System;circulating microRNA;Circulation;clinically relevant;Communication;Congestive Heart Failure;Cytosol;Data;Down-Regulation;Enzymes;Equilibrium;Erythroid;Extracellular Space;extracellular vesicles;Fibroblasts;Functional disorder;Goals;Heart;Heart failure;Homeostasis;Human;human tissue;Impairment;inhibitor;innovation;intercellular communication;Intervention;Knowledge;Mediating;Mediator;Membrane;Messenger RNA;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Muscle Cells;Myocardial;Myocardial Infarction;Myocardium;Myofibroblast;Nerve;Neural Pathways;novel;novel therapeutics;Nuclear;Organ;Oxidation-Reduction;oxidative damage;Oxidative Regulation;Oxidative Stress;Paracrine Communication;Pathogenesis;Pathologic;Pathologic Processes;Pathway interactions;Patients;Phenotype;Physiological Processes;Process;Proteins;Rattus;Reactive Oxygen Species;Regulation;Reporter;Research;Rodent;Signal Transduction;Surface;Techniques;therapeutic miRNA;Therapeutic Uses;Time;transcription factor;Translational Repression;Translations;Ubiquitination;vesicle transport;vesicular release

PROJECT_TITLE: Nrf2 regulation of oxidative stress in heart failure and extra vesicular communication

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: GENETICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Astrocytes serve critical roles in the function of the brain, such that disruptions to astrocytes underlie several neurodevelopmental disorders, making it crucial to improve our understanding of the signals that direct astrocyte development. This proposal will investigate primary cilia, signaling antennae present in almost every cell with critical roles in development, to determine how they regulate different stages of astrocyte development. This work will inform novel functions of astrocyte cilia and advance our fundamental understanding of ciliary signaling in developing astrocytes.

PI_NAMEs: BEAR, RACHEL MARIE (contact)

PROJECT_TERMS: Ablation;Affect;Astrocytes;Biology;Brain;Cell Cycle;Cell Cycle Progression;cell type;Cells;Cellular Morphology;Cilia;ciliopathy;Cues;Data;Development;Developmental Gene;Disease;Disparate;Essential Genes;Excision;experimental study;Fluorescent in Situ Hybridization;Foundations;Functional disorder;General Population;Genes;Genetic;Genetic Transcription;Goals;Hand;improved;in vivo;Individual;Knowledge;Label;Link;Mammalian Cell;Mentorship;Microtubules;Monitor;Morphology;mouse model;mRNA Expression;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neuroglia;Neurologic;neuron development;Neurons;novel;Pathology;Play;Population;Positioning Attribute;programs;Proliferating;Research;Research Design;Role;Signal Transduction;Stains;Structure;Synapses;System;Time;tool;Transcript;transcriptomics;Work

PROJECT_TITLE: The Novel Role of Cilia in Astrocyte Sevelopment


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

PHR: Project Narrative Drinking becomes excessive when it causes or elevates the risk for alcohol-related problems or complicates the management of other health problems. The alarming prevalence of excessive alcohol use (EAU) among veterans is concerning and the vigilance and action to identify veterans with EAU is of importance. The consequences of under-detection of EAU, thus delayed intervention are serious because the potential consequence of adverse alcohol-related health conditions is increased with the quantity and duration of alcohol consumed. In this application, we propose to systematically study novel and mechanism-based biomarkers as the screening tool for EAU. Further, we will determine the diagnostic performance of a risk model for EAU prediction using statistical mechanics.

PI_NAMEs: LIANGPUNSAKUL, SUTHAT  (contact)

PROJECT_TERMS: Abstinence;adverse outcome;Alcohol consumption;alcohol measurement;alcohol monitoring;alcohol rehabilitation;alcohol related problem;alcohol risk;alcohol screening;Alcohols;Anemia;Award;Biological Markers;biomarker panel;Body System;Caring;Cells;Clinical;clinical care;clinical practice;Consumption;Counseling;Dangerousness;Data;Detection;Diabetes Mellitus;Diagnosis;Diagnostic;Disease;disease phenotype;drinking;drinking behavior;Dyslipidemias;Functional disorder;Funding;Glucose;Goals;Health;Hemoglobin;Human;Individual;Inflammatory;Inflammatory Response;Intervention;Laboratories;Link;Lipids;Machine Learning;Methods;Modeling;monocyte;novel;Pathology;Pathway interactions;Patient Self-Report;Patients;Performance;potential biomarker;Prevalence;Process;Proteomics;Questionnaires;Relapse;relapse patients;Relative Risks;Research;response;Risk;risk prediction model;Role;screening;Screening procedure;Sensitivity and Specificity;Serum;Statistical Mechanics;Systems Biology;Testing;Time;transcriptomics;trend;Validation;Veterans;vigilance

PROJECT_TITLE: Mechanism-based serum biomarkers and validation of ensemble model for excessive alcohol use


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse;Women's Health Research

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Alcohol use disorder directly affects over 16 million individuals in the United States alone and presents a tremendous burden on society. The neuronal circuits that drive the negative affective state associated with alcohol dependence are only beginning to be understood. The present proposal will seek to gain a better understanding of the role of the basolateral amygdala to ventral subiculum circuit in a rodent model of alcohol dependence in an effort to identify novel neural substrates for the development of more effective treatments for alcohol use disorder.

PI_NAMEs: BACH, EVA CLAUDIA (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Abstinence;Affect;Affective;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol research;alcohol use disorder;Alcohol withdrawal syndrome;Amygdaloid structure;Anti-Anxiety Agents;Anxiety;anxiety-like behavior;associated symptom;Automobile Driving;Behavior;Biological Assay;career development;Chronic;Communication;Data;Desire for food;Development;effective therapy;Electrophysiology (science);Elements;Equilibrium;experience;Experimental Genetics;experimental study;Exposure to;Female;Fiber;functional plasticity;genetic approach;Genetic study;Glutamates;Goals;hippocampal pyramidal neuron;Hippocampus;Human;Individual;interest;Knowledge;male;Measures;Mediating;Mentors;Mentorship;Modeling;multidisciplinary;negative affect;neural;neuroadaptation;neuromechanism;neuronal circuitry;neuronal excitability;Neurons;neurotransmission;next generation;novel;Optics;optogenetics;Pathway interactions;Pattern;Phenotype;Photometry;Play;Population;protective effect;Proxy;Pyramidal Cells;Rattus;Relapse;Research Personnel;response;Rodent;Rodent Model;Role;sex;sexual dimorphism;Signal Transduction;skills training;Societies;Symptoms;Synapses;Techniques;Testing;Time;Tracer;Training;United States;Withdrawal

PROJECT_TITLE: Basolateral amygdala to ventral subiculum network plasticity in alcohol dependent male and female rats

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Connections between neurons are sculpted during brain development by the complement system, a network of proteins that normally works with immune cells throughout the body to help fight infection and cleanup damaged tissue. We are investigating the function of the Sez6 gene family to determine if it controls abnormal complement activation in the brain and whether this contributes to the incorrect connections between nerve cells that can give rise to autism spectrum disorders (ASD). By understanding how this contributes to ASD we hope to design treatments in the future that repair this pathway to protect the brain from ASD.

PI_NAMEs: HAMMOND, JENNETTA W (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Adult;Affect;ASD patient;autism spectrum disorder;Biological Assay;Bipolar Disorder;Brain;Cell membrane;Cell surface;Cells;Cerebellum;cognitive disability;Complement;Complement Activation;Complement Inactivators;complement pathway;complement system;Cytoplasmic Tail;Data;Dendrites;density;Deposition;Development;Disease;enhancing factor;Environmental Risk Factor;Epilepsy;Excision;Family;family genetics;Family member;fighting;functional outcomes;Future;Gene Family;Genes;Genetic;genetic regulatory protein;Goals;Grant;Hippocampus;Immune;immune activation;Immune System Diseases;Impaired cognition;improved;in vitro Assay;Infection;Inflammation;Inflammatory;inflammatory milieu;insight;Intellectual functioning disability;Knock-out;Knockout Mice;Mediating;member;Microglia;Missense Mutation;Modeling;Morphology;Motor;motor deficit;motor impairment;motor learning;Mus;neural circuit;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;novel;Pathogenesis;Pathway interactions;Phenotype;Poly I-C;Process;programs;protective factors;Proteins;Regulation;repaired;Research;Role;Schizophrenia;Self Direction;Serum;Shapes;Surface;Symptoms;Synapses;Synaptic plasticity;synaptic pruning;Tertiary Protein Structure;Testing;Therapeutic;therapy design;timeline;Tissues;Translating;Work

PROJECT_TITLE: Sez6 proteins as protection factors in complement-mediated synaptic pruning


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Diabetes;Immunotherapy;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The objective of this project is to induce localized immune tolerance to transplanted human beta cells derived from renewable stem cell sources as a treatment for type 1 diabetes. This project presents a significant step forward in the development of alternative, renewable, and off-the-shelf sources of insulin producing cells for current cell replacement therapy efforts. This project addresses the key technical challenge of systemic administration of immunosuppressive drugs to protect beta cell grafts through introduction of a highly localized immunomodulation and as such, represents the highest level of translational innovation.

PI_NAMEs: PHELPS, EDWARD  (contact);RUSS, HOLGER A.

PROJECT_TERMS: Adamantane;Address;anergy;Animal Model;antigen-specific T cells;Antigens;Apoptosis;Architecture;Area;Attenuated;Autoantigens;autoimmune pathogenesis;Autoimmunity;Automobile Driving;behavior influence;Beta Cell;beta cell replacement;beta-Cyclodextrins;Biocompatible Materials;Biological;Biological Assay;Biological Response Modifiers;Biology;Biomedical Engineering;Cadaver;Categories;cell killing;Cell Physiology;cell replacement therapy;Cell surface;Cell Transplantation;Cells;cellular engineering;Chemistry;Clone Cells;Coculture Techniques;Collaborations;compare effectiveness;crosslink;cytotoxic CD8 T cells;design;Development;Diabetes Mellitus;Diabetic mouse;effector T cell;Elements;Encapsulated;engineered stem cells;Engineering;Engraftment;Eragrostis;Exhibits;experimental study;Gel;Generations;Genes;Genome engineering;Glucose;graft function;Graft Rejection;Graft Survival;Human;human model;human stem cell-derived;humanized mouse;Hydrogels;Immune;Immune mediated destruction;Immune system;Immune Tolerance;Immunity;immunoengineering;Immunomodulators;immunoregulation;Immunosuppression;Immunosuppressive Agents;Immunotherapy;Impairment;In Vitro;in vitro Model;in vivo Model;Induction of Apoptosis;Injectable;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;islet;Islet Cell;Islets of Langerhans Transplantation;Knowledge;Ligands;Mechanics;Microspheres;novel;particle;Pathway interactions;Patients;Performance;Polyethylene Glycols;Porosity;pre-clinical;prevent;programmed cell death ligand 1;Property;Reaction;receptor;Resistance;response;revascularization;side effect;Source;Specificity;stem cell biology;stem cells;Structure;Surface;synergism;System;T cell response;T-Lymphocyte;Technology;Testing;therapeutic target;Thinness;TNF gene;Transgenic Animals;Transplantation;Vascularization;Work

PROJECT_TITLE: Local immune modulation for beta cell replacement therapy in type 1 diabetes

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Lymphatic Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The proposed research is relevant to public health because vascular deficiencies are among the leading causes of cardiovascular disease and disorders, but their causes and underlying mechanisms are poorly understood. The results of the proposed studies will significantly contribute to a better understanding of the molecular and cellular mechanisms underlying the role of paracrine signaling derived from the vascular system in the regeneration and repair of ischemic tissues via activation of tissue-specific stem cells and stem cell niches. Thus, the proposal is relevant to the part of NIH’s mission and is likely to lead to the identification new targets and therapeutic strategies for improving vascular repair and tissue regeneration in affected patients.

PI_NAMEs: KUME, TSUTOMU  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Affect;angiogenesis;Animals;Attenuated;autocrine;B-Lymphocytes;beta catenin;Blood Vessels;Cardiovascular Diseases;Cells;CXCR4 gene;Data;Defect;Deposition;Disease;Embryo;Endothelial Cells;Endothelium;experimental study;Extravasation;FOXC1 gene;FOXC2 gene;gene function;Genetic Transcription;Goals;Growth;Homeostasis;Impairment;improved;injury recovery;intestinal injury;Intestines;Investigation;Ischemia;Ischemic Bowel Disease;Knock-out;lymphatic vessel;mature animal;Mission;Molecular;Mucous Membrane;Mus;Mutation;Natural regeneration;paracrine;Paracrine Communication;Participant;Pathologic;Pathway interactions;Patients;Perinatal mortality demographics;Phenotype;Process;Proliferating;Public Health;Recovery;repaired;Reperfusion Injury;Reperfusion Therapy;Research;restoration;Role;role model;Signal Transduction;single-cell RNA sequencing;Small Intestines;stem cell niche;stem cells;Stromal Cell-Derived Factor 1;Stromal Cells;Tamoxifen;Testing;Therapeutic;tissue regeneration;tissue repair;Tissues;United States National Institutes of Health;Vascular Endothelial Cell;Vascular Permeabilities;Vascular System;Villus

PROJECT_TITLE: New roles of endothelial regrowth in ischemic tissue recovery and regeneration

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Vector-Borne Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Mosquitoes employ their olfactory receptors to detect and prey on humans, transmitting grave diseases that kill over a million people yearly; however, the molecular mechanism by which olfactory receptors interact with odorant molecules remains elusive. The proposed research program will provide the first structural and mechanistic characterization of insect olfactory receptors bound to odors, including human-emitted volatiles. This work will shed light on the basic biochemical mechanism of odor detection and enable the development of novel insect repellents that bind to olfactory receptors and prevent human host-seeking, addressing the relentless spread of insect-borne diseases.

PI_NAMEs: DEL MARMOL, JOSEFINA INÉS (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Advisory Committees;Aedes;Affect;Alleles;Amino Acid Receptors;Amino Acid Sequence;Animals;Appointment;Behavioral Assay;Binding;Biochemical;Biological Assay;Biophysics;career development;Chemicals;combinatorial;Complex;Computer Models;Cryoelectron Microscopy;Culicidae;Data;Dengue Fever;Detection;Development;Development Plans;Discrimination;Disease;Drosophila genus;Drosophila melanogaster;drug discovery;Electrophysiology (science);Elements;Endowment;Engineering;Environment;Exhibits;Family;flexibility;Foundations;Functional Imaging;Genetic;Genetic Polymorphism;Goals;Human;Impairment;In Vitro;in vivo;insect disease vector;Insect Repellents;Insecta;insight;Leadership;Ligand Binding;Ligands;Light;Link;Logic;Malaria;Mammals;Manuscripts;Mentors;Mentorship;Modality;Molecular;molecular modeling;Mutagenesis;Mutation;Neurons;novel;Odorant Receptors;Odors;Olfactory Pathways;olfactory receptor;olfactory stimulus;Persons;Phase;Positioning Attribute;preference;Preparation;prevent;programs;Property;rational design;receptor;receptor binding;Research;Research Project Grants;Resolution;Resources;response;Ruta;Sensory;skills;small molecule;Smell Perception;Specificity;structural biology;structural determinants;Structure;System;Technology;Testing;tool;Training;transmission process;Universities;Variant;Volatilization;Work;Yellow Fever;zika fever

PROJECT_TITLE: Elucidating the structural determinants of odor specificity in insect olfactory receptors


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Physical Activity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: FAMILY MEDICINE

PHR: PROJECT NARRATIVE The goal of the K23 proposal is to provide necessary training in cultural adaptation, implementation science, and social network analysis to determine whether a social network-focused lifestyle intervention, based in a primary care setting, is feasible and acceptable for immigrant men from South Asia and West Africa and whether health behaviors will improve among participants’ social networks. The proposed work aims to develop a community-informed program, based on evidence-based lifestyle programs, adapted for the specific needs for immigrant men and to understand the diffusion of health behaviors among participants’ social networks, a potentially untapped resource for lifestyle behavior change.

PI_NAMEs: SHAH, MEGHA  (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Affect;Africa;African;Asia;Award;Behavior;Behavior assessment;behavior change;behavioral outcome;Belief;Biometry;Blood Pressure;Body Weight;Calories;career;career development;Child;Clinic;Clinic Visits;clinical care;clinical practice;Clinical Sciences;Communities;cost;Data;data hub;Dedications;design;Development Plans;Diabetes Mellitus;diabetes risk;diabetes self-management;Diet;Diffusion;disparity reduction;Education;Educational Curriculum;epidemiologic data;ethnic minority;European;Evaluation;evidence base;experience;Family;Family member;Family Practice;Focus Groups;Friends;Funding;Gender;Generations;glycemic control;Glycosylated Hemoglobin;Goals;Grant;group intervention;Habits;Health;Health behavior;health care disparity;Health education;health outcome disparity;Health Services Accessibility;Health system;healthy lifestyle;High Prevalence;high risk;high risk population;Home;hypertension control;Immigrant;Immigrant community;implementation science;improved;Individual;innovation;Intervention;intervention program;K-Series Research Career Programs;Latino Population;Life Cycle Stages;Life Style;lifestyle factors;lifestyle intervention;Lipids;male;Manuscripts;Maps;Measurement;medical appointment;member;men;Minority;Modeling;Morbidity - disease rate;mortality;Motivation;Muslim population group;Native Americans;Native-Born;Natural experiment;Network-based;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Participant;Pathway Analysis;patient oriented;patient population;Patient Recruitments;Patients;peer;Perception;personalized care;Physical activity;Pilot Projects;Plasma;Population;Prediabetes syndrome;preference;prevent;Primary Care;primary care setting;primary outcome;programs;Protocols documentation;recruit;Research;Resources;Role;Rural;satisfaction;Scientist;secondary outcome;Site;skills;social;Social Network;South African;South Asian;Spouses;Testing;Training;Translational Research;translational study;Underrepresented Populations;uptake;Vulnerable Populations;Weight;Weight maintenance regimen;Woman;Work;Writing

PROJECT_TITLE: Better Together: Leveraging primary care and social network resources to create a patient-centered approach to improve diabetes among immigrant communities


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Substance Misuse

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Research has established that compounds aimed at CRF receptors are protective against dependence-induced alcohol drinking, and our recent findings show that compounds targeting CRF receptors are also protective against excessive binge-like drinking in mice when targeted to regions of that modulate stress and emotional behaviors. Expected results in the current application will significantly expand our recent observations by showing the CRF circuits linking stress and reward centers in the brain modulate binge-like ethanol drinking.

PI_NAMEs: KASH, THOMAS L.;THIELE, TODD ERIC (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Address;Agonist;Alcohol consumption;alcohol use disorder;Alcoholism;Alcohols;Amygdaloid structure;antagonist;Attention;Behavior;binge drinking;biological adaptation to stress;Blood;Brain;Brain region;cell type;Cells;Communication;Complement;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;CRF receptor type 1;CRH gene;Dangerous Behavior;Dangerousness;Data;Dependence;Development;Disease;drinking;Electrophysiology (science);emotional behavior;Emotions;Ethanol;Ethanol dependence;Exhibits;Female;Funding;gamma-Aminobutyric Acid;Genetic;genetic approach;genetic manipulation;Glutamates;Goals;Grant;Health;Heavy Drinking;Histologic;hypocretin;Hypothalamic structure;In Situ;Individual;Infusion procedures;Injections;innovation;insight;Investigation;knock-down;Knowledge;Label;Laboratories;Lateral;Link;Literature;male;Messenger RNA;mRNA Expression;Mus;National Institute on Alcohol Abuse and Alcoholism;neural circuit;Neurobiology;neurochemistry;Neurons;novel;Pathway interactions;Pattern;pharmacologic;Pharmacologic Substance;problem drinker;Property;protein expression;receptor;Receptor Signaling;Recording of previous events;Relapse;Research;Rewards;Risk;Role;sex;Sex Differences;Signal Transduction;Site;Slice;Stress;System;Technology;Testing;Time;tool;Transgenic Organisms;Viral;Western Blotting

PROJECT_TITLE: The role of corticotropin releasing factor in binge-like ethanol drinking


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Cerebrovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Infant Mortality;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Rare Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed project will explore MRI markers that can objectively identify individuals as early as possible who have brain abnormalities and would therefore benefit from therapeutic interventions in congenital heart disease (CHD). It will also determine relative effects of deleterious genetic variants and oxygenated cerebral blood supply on abnormal cortical development and will inform us potential causes and mechanisms of the abnormalities in CHD. Our quantitative markers may be useful for evaluating the impact and success of therapeutic interventions and understanding the efficacy and mechanisms of action of the interventions.

PI_NAMEs: IM, KIHO  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Affect;Alleles;Aorta;aortic arch;Area;Birth;Brain;brain abnormalities;brain magnetic resonance imaging;Brain region;brain volume;Cardiovascular system;cerebral hemodynamics;cerebral oxygenation;Cerebrovascular Circulation;Cerebrum;Child;cognitive function;cohort;Congenital Disorders;congenital heart abnormality;Development;Early identification;Early Intervention;exome sequencing;fetal;Fetal Development;Fetus;Foundations;frontal lobe;Future;Gene Expression;Genes;Genetic;genetic variant;Growth;Heart;hemodynamics;high risk;hypoperfusion;Hypoplastic Left Heart Syndrome;imaging study;Impairment;in utero;Individual;Injury;insight;Intervention;large datasets;late life;Live Birth;Lung;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Methods;Monitor;neonatal period;Neurodevelopmental Disability;neurogenesis;neuroprotection;Obstruction;Oxygen;Patients;Pattern;Perfusion;Placenta;Prefrontal Cortex;prenatal;prospective;resilience;Risk;Role;Second Pregnancy Trimester;sex;Single ventricle congenital heart disease;Site;Socioeconomic Status;success;Surface;Therapeutic Intervention;Thick;Third Pregnancy Trimester;Time;Treatment Efficacy;Variant;Vascular blood supply

PROJECT_TITLE: Genetic and Hemodynamic Effects on Prenatal Cortical Development in Congenital Heart Disease


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Cancer;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative The computerized spinal stability assessment, for patients who have cancer that has spread to their spine, will offer more accurate prediction of the need for spine surgery to the patients, and with a much greater likelihood that the patients and their families can get the evaluation done promptly near their home, saving them time, expense, and inconvenience. The recommendation for non-surgical treatment will be made with increased assurance that the risk of a spine fracture is low, and the analysis methods will provide additional guidance on allowable, safe levels of their activities of daily living, which typically stratify out to household ambulation, community ambulation, and various levels of exercise and load bearing activities (e.g., carrying grandchildren, groceries, laundry, yard work). Those patients, who do need surgery, will be offered minimally invasive surgical techniques that will shorten their hospital stay and recovery time, and allow them to return home to their families sooner.

PI_NAMEs: ELDER, BENJAMIN D;LU, LICHUN  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Activities of Daily Living;Address;Affect;base;Biocompatible Materials;biomaterial compatibility;Biomechanics;Biomimetics;bone;Bone Cements;Cadaver;Calibration;Caring;catalyst;Cauda Equina;Cementation;Chemicals;Chemistry;Clinic;Clinical;clinical implementation;clinical translation;clinically relevant;Communities;Complex;computerized;Counseling;crosslink;Data;Decision Making;Defect;Development;Disease;Disseminated Malignant Neoplasm;Elements;Evaluation;Exercise;Failure;Family;Finite Element Analysis;Formulation;Fracture;fracture risk;Future;grandchild;Grant;high risk;Home;Household;Human;Hydrogels;improved;indexing;Injectable;Institution;Intervertebral disc structure;kinematics;Length of Stay;Link;Lytic;Malignant Neoplasms;mechanical properties;Mechanics;Methodology;Methods;minimally invasive;Modeling;Motion;Nature;Neoplasm Metastasis;Nervous System Trauma;Network-based;neural;novel;operation;Operative Surgical Procedures;Outcome Study;Pain;Paralysed;Patient Care;Patients;Periosteum;Physiological;poly(propylene fumarate);Polymers;prevent;Prevention;Procedures;Process;programs;prophylactic;Protocols documentation;quantitative computerized tomography based finite element analysis;Recommendation;reconstitution;reconstruction;Recovery;Rehabilitation therapy;Reproducibility;Research;Residual state;Retrospective cohort;Risk;risk prediction;Robotics;Scanning;Spinal;spinal cord compression;Spinal Fractures;Spinal Neoplasms;Spinal nerve structure;spine bone structure;Spine surgery;Stretching;Surgical Oncology;System;Techniques;Testing;Time;tumor;vertebra body;Vertebral column;virtual;virtual assessment;Weight-Bearing state;Work;X-Ray Computed Tomography

PROJECT_TITLE: Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment - Master

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative The National Academies of Science (NAS) and several other entities have identified a critical shortage of veterinarians in research, and the NIH has identified a need for increased emphasis in clinical and translational research. These issues have a direct bearing on the health and welfare of the US public - most notably veterinary scientist contributions to animal models of human health and disease and most critically, in zoonotic diseases. The proposed training program addresses both these essential needs by increasing the pool of veterinarians with exposure to careers in research, and based on the history of the program, it is anticipated that a significant number of these trainees will pursue advanced training in research.

PI_NAMEs: BJORLING, DALE EDMOND;JORGENSEN, JOAN S (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Animal Welfare;career;Communication;Data Reporting;design;Educational Curriculum;Educational workshop;Environment;experience;Exposure to;Goals;Health;Human;Institution;interest;Knowledge;Laboratories;Learning;Medical Students;meetings;Mentors;Minority;Oral;Performance;Process;programs;prospective;recruit;Research;Research Ethics;Research Training;responsible research conduct;Schedule;Scholars Program;Science;skills;Students;success;summer research;symposium;Techniques;Testing;timeline;tool;Training;Training Programs;United States National Institutes of Health;Universities;Veterinary Medicine;Veterinary Schools;Wisconsin;Writing

PROJECT_TITLE: Short-term Research Training for Veterinary Students in Wisconsin


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative autism including models dysfunction is one of several disorders in humans that are amongst a broader group of spectrum disorders (ASDs). Individuals with FXS and ASDs can exhibit a range of debilitating deficits, in their processing of incoming sensory information. Studies outlined in this proposal in mouse for FXS will provide in such individuals. Fragile X syndrome (FXS) fundamental information about mechanisms that could underlie olfactory

PI_NAMEs: SCHOPPA, NATHAN ERIC (contact)

PROJECT_TERMS: Animal Behavior;Animals;Association Learning;autism spectrum disorder;awake;Behavior;Behavioral;behavioral impairment;Binding Proteins;Brain;cell type;Cells;cognitive ability;Communication;Data;Development;Disease;Electric Stimulation;Electrophysiology (science);Equilibrium;Exhibits;experimental study;Female;fly;FMR1 gene;Foundations;Fragile X Gene;Fragile X Syndrome;Frequencies;Functional disorder;Future;Gene Expression;Glutamate Decarboxylase;Goals;granule cell;Human;Hypersensitivity;Impairment;in vivo;Individual;Induced Mutation;interdisciplinary approach;Interneurons;Link;male;Mediating;Messenger RNA;Methods;mitral cell;Modality;Modeling;Morphologic artifacts;mouse model;Mus;Mutation;neural;odor discrimination;Odors;olfactory bulb;Olfactory Pathways;Output;patch clamp;Performance;Protein Isoforms;Proteins;Recovery;Rodent;Role;Sensory;sensory system;signal processing;Slice;Smell Perception;social communication;Social Interaction;Structure;Synapses;System;Tamoxifen;Testing;Translations;X Chromosome

PROJECT_TITLE: Mechanisms of olfactory signal processing

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: PATHOLOGY

PHR: The vervet/African green monkey (AGM) is a valuable nonhuman primate model for studies of aging and  Alzheimer's disease, cardiometabolic disorders, infectious disease and vaccine development,  neuroscience, and genetics. The Vervet Research Colony (VRC) is the only NIH-supported biomedical  research resource dedicated to providing animals, biological samples, and data, as well as training  and consultation on the use of vervets/AGMs for translational research. Continued genetic and  phenotypic characterization of the vervet, along with the maintenance and expansion of the VRC data  archive and biological sample repository are all critical for meeting the needs of the scientific  community.

PI_NAMEs: JORGENSEN, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Address;African Green Monkey;Age;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;animal resource;Animals;Applied Research;Area;Autopsy;Behavioral;Biological;Biological Markers;biomedical imaging;Biomedical Research;biomedical resource;Biopsy;Blood Chemical Analysis;Cardiometabolic Disease;cardiometabolism;career;Caribbean region;Cercopithecus tantalus;Cerebrospinal Fluid;Clinical and Translational Science Awards;clinical care;clinical phenotype;Communicable Diseases;Communities;comparative;Consultations;Data;data archive;data repository;Dedications;Dengue Fever;Development;Diabetes Mellitus;Discipline;Ensure;Etiology;Evaluation;Fatty acid glycerol esters;Fostering;Funding;gene therapy;Genetic;genetic pedigree;genetic resource;Genome;Genomics;Genotype;Health;human disease;human model;image translation;imaging capabilities;imaging program;Influenza;Infrastructure;interest;Investigation;life span;Lipids;Maintenance;Measurement;medical schools;Medicine;meetings;Metabolic;Metabolic Diseases;Methodology;Mothers;Multimodal Imaging;Muscle;Neonatal;Neurodegenerative Disorders;Neurosciences;nonhuman primate;novel;Obesity;outreach;pathogen;Pathology;Phenotype;phenotypic data;Physiological;Placenta;Plasma;Play;Population;precision medicine;Primates;programs;psychosocial development;repository;reproductive;Research;research facility;Research Personnel;Resources;Respiratory syncytial virus;Role;Sampling;screening;Serum;Services;Site;social group;Source;Study models;Synapses;System;Technical Expertise;Tissues;Training;training opportunity;translational model;translational potential;Translational Research;translational study;United States National Institutes of Health;vaccine development;Vaccines;vervet;Veterinarians;Viral;β-amyloid burden

PROJECT_TITLE: Vervet Research Colony as a Biomedical Resource

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-D(50)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Infectious Diseases;Neurodegenerative;Neurosciences

PROJECT_TERMS: Address;African Green Monkey;Age;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;animal resource;Animals;Applied Research;Area;Autopsy;Behavioral;Biological;Biological Markers;biomedical imaging;Biomedical Research;biomedical resource;Biopsy;Blood Chemical Analysis;cardiometabolism;career;Caribbean region;Cercopithecus tantalus;Cerebrospinal Fluid;Clinical and Translational Science Awards;clinical care;clinical phenotype;Clinical Sciences;Communicable Diseases;Communities;comparative;Consultations;Data;data repository;Dengue Fever;Development;Diabetes Mellitus;Discipline;Ensure;Etiology;Evaluation;Fatty acid glycerol esters;Fostering;Funding;gene therapy;Genetic;genetic pedigree;genetic resource;Genome;Genomics;Genotype;Health;human disease;human model;image translation;imaging capabilities;imaging program;Influenza;Infrastructure;Institution;interest;Investigation;life span;Lipids;Measurement;medical schools;Medicine;meetings;Metabolic;Metabolic Diseases;Methodology;Mothers;Multimodal Imaging;Muscle;Neonatal;Neurodegenerative Disorders;nonhuman primate;novel;Obesity;outreach;pathogen;Pathology;Phenotype;phenotypic data;Physiological;Placenta;Plasma;Play;Population;precision medicine;Primates;programs;psychosocial development;repository;reproductive;Research;research facility;Research Personnel;Resources;Respiratory syncytial virus;Role;Sampling;screening;Serum;Services;Site;social group;Source;Study models;Synapses;System;Technical Expertise;Tissues;Training;training opportunity;translational model;translational potential;Translational Research;translational study;United States National Institutes of Health;Vaccines;vervet;Veterinarians;Viral;β-amyloid burden

PROJECT_TITLE: Component for Institution # 19-01414

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-D]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Genetics;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health

ORG_CITY: FARMINGTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE The perinatal period presents a `window of opportunity' for environmental stressors and caregiver mental health to impose risk to infant offspring; however, the mechanisms underlying these pathways are not fully understood, especially in the context of a large-scale disaster such as the COVID-19 pandemic. The fundamental scientific premise of the proposed study is that perinatal stress, enhanced by an unprecedented pandemic, is linked to caregiver posttraumatic stress and emotion dysregulation, which in turn shapes the early caregiving environment influences infant stress reactivity and dysregulation through biobehavioral processes, including DNA methylation and cellular aging. This time sensitive work is critical for identifying and driving novel approaches to prevention and intervention in vulnerable populations, especially during times of crisis.

PI_NAMEs: BRIGGS-GOWAN, MARGARET J;GRASSO, DAMION JOSEPH (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: Address;adverse outcome;Age Months;Automobile Driving;Behavioral;biobehavior;Biological;biological adaptation to stress;caregiver stress;Caregivers;caregiving;Cell Aging;Child;Child Rearing;childhood adversity;cohort;Cohort Studies;Communities;COVID-19 pandemic;Data;Development;Disasters;DNA;DNA Methylation;early childhood;emotion dysregulation;emotion regulation;Emotional;Emotions;Environment;environmental stressor;Epidemic;Epigenetic Process;Equipment and supply inventories;ethnic diversity;Ethnic Origin;experience;Exposure to;Failure;Family;Financial Hardship;genome-wide;Health;Home visitation;Impairment;Individual;Infant;infant outcome;insight;Intervention;Interview;Knowledge;Latina;Length;Life;Link;maternal stress;Measures;Mediating;Mediator;Mental Health;Methods;Methylation;Modeling;Mothers;Newborn Infant;next generation;novel strategies;offspring;Outcome;pandemic disease;pandemic impact;pandemic stress;Parent-Child Relations;Pathway interactions;Pattern;perceived stress;Perinatal;perinatal period;person centered;Phase;phase 1 study;Population;post-traumatic stress;Post-Traumatic Stress Disorders;Pregnancy;Pregnancy Trimesters;pregnant;prenatal;prenatal stress;Preparation;Prevalence;prevent;Prevention approach;Problem behavior;Procedures;Process;Protocols documentation;psychologic;public health intervention;Race;recruit;Regulation;Reporting;Risk;saliva sample;sample collection;Sampling;Severities;Shapes;Site;social;Stress;stress reactivity;stress related disorder;Subgroup;Surveys;telomere;Telomere Shortening;Testing;Time;trauma exposure;Vulnerable Populations;Woman;Women's cohort;Work

PROJECT_TITLE: Impact of Perinatal Pandemic-Related Stress on the Early Caregiving Environment, Infant Functioning, DNA Methylation, and Telomere Length

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Neurosciences;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: Our team has developed a library of CB1 negative allosteric modulators (NAMs) and found one such NAM RTICBM-74 dose-dependently reduces alcohol consumption without inducing anxiety-like behaviors in rats. This project aims to further optimize and validate these promising CB1 NAMs as potential therapeutics for the treatment of alcohol use disorder by assessing their in vivo efficacies and psychiatric effects.

PI_NAMEs: BESHEER, JOYCE ;ZHANG, YANAN  (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: acamprosate;Acute;Affect;Agonist;alcohol abuse therapy;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol reinforcement;alcohol relapse;alcohol seeking behavior;alcohol use disorder;alcoholism therapy;Alcohols;Anhedonia;Animal Model;antagonist;Anxiety;anxiety-like behavior;anxiety-related behavior;arm;Attenuated;Behavior;Behavior assessment;Binding;Biological Assay;Brain;Chronic;CNR1 gene;CNR2 gene;Cocaine;Computer Models;Consumption;Cue-induced relapse;Data;Dependence;design;Development;Disulfiram;Dose;Drug Kinetics;drug-like compound;Effectiveness;Endocannabinoids;Enzymes;Ethanol;Europe;European;Evaluation;G-Protein-Coupled Receptors;Goals;Health;Human;improved;in silico;In Vitro;in vitro Assay;in vivo;Intake;Ion Channel;Libraries;Ligand Binding;Ligands;lipophilicity;Marketing;Mental Depression;Metabolic;Modeling;Motivation;motor behavior;Naltrexone;neurotransmission;nonhuman primate;novel;obesity treatment;Pharmaceutical Preparations;Play;Pre-Clinical Model;process optimization;Property;Psychological reinforcement;radioligand;Rattus;receptor;Relapse;relapse prevention;Reporting;response;rimonabant;Role;Self Administration;Series;Severities;side effect;Signal Transduction;Site;Social Interaction;Societies;Solubility;SR141716;Sucrose;System;Testing;Therapeutic;Time;translational potential;treatment strategy;Urea;Wistar Rats;Withdrawal

PROJECT_TITLE: Allosteric Modulation of the CB1 Receptor

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]