NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE This project focuses on the Type 7b Secretion System (T7bSS) of Staphylococcus aureus where it facilitates persistent disease. The project examines the assembly and structure of this secretion system, the role of the peptidoglycan hydrolase EssH for the secretion of effector proteins and the mechanism whereby the Agr quorum sensing pathway controls this system. The T7bSS is poorly characterized and unique to pathogenic Gram-positive bacteria such as S. aureus, Listeria monocytogenes, Bacillus cereus and several Streptococci sp.

PI_NAMEs: BOBROVSKYY, MAKSYM  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Abscess;Academia;Advisory Committees;antimicrobial;Area;ATP Hydrolysis;ATP phosphohydrolase;Award;Bacillus cereus;Bacterial Physiology;Base Pairing;Biochemical;Blood Circulation;career;career development;Cell Density;cell envelope;Cell Wall;Chicago;Clinical;Communities;Complex;Core Facility;Coupled;crosslink;Cryoelectron Microscopy;Defect;Development;Disease;disease model;Electron Microscopy Facility;Elements;Environment;Equipment;experience;Future;Gene Cluster;Gene Expression Regulation;Genes;Genetic;Genetic Screening;Genus staphylococcus;Goals;Gram-Positive Bacteria;Growth;high risk;Human;Hydrolase;Immune response;in silico;Industry;Infection;Infectious Skin Diseases;Inflammatory;insight;Interdisciplinary Study;International;Laboratories;Lesion;Light;Listeria monocytogenes;Mass Spectrum Analysis;Membrane;Membrane Proteins;Mentors;Messenger RNA;Microbiology;Molecular;Mus;mutant;N-Acetylmuramoyl-L-alanine Amidase;Operon;Osteomyelitis;particle;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Peptidoglycan;Phase;Phenocopy;Post-Transcriptional Regulation;posttranscriptional;Production;protein complex;Protein Family;protein protein interaction;Protein Secretion;Proteins;Protocols documentation;quorum sensing;Recording of previous events;Regulation;Regulator Genes;Research;Resolution;Rice;Risk Factors;RNA;RNAIII;Role;Scientist;Sepsis;Set protein;Site;soft tissue;Staphylococcus aureus;stem;stoichiometry;Streptococcus;Structural Biologist;Structural Protein;Structure;System;Testing;Thick;Tissues;tool;Training;training opportunity;Translation Initiation;Translations;United States;Universities;Virulence;Virulence Factors;Work

PROJECT_TITLE: Staphylococcus aureus Type 7b Secretion System assembly and regulation

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research;Youth Violence

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE There is a critical need for effective and scalable intervention approaches for reducing suicidal behavior and related crises among psychiatrically hospitalized adolescents transitioning from inpatient care. Leveraging a novel sequential multiple assignment randomized trial (SMART) design, the project will identify an effective technology-augmented intervention package that will guide the adaptive delivery of post-discharge support— provided via text messages, asynchronous portal communication, and booster calls—in a tailored and resource-efficient way. Proposed to address current recruitment shortfalls, this administrative supplement will enable completing the study’s target enrollment goals and achieving its originally-proposed aims.

PI_NAMEs: CZYZ, EWA KARINA (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: Acute;adaptive intervention;Address;Administrative Supplement;Admission activity;Adolescent;Area;Black race;Caregivers;Caring;Cellular Phone;Child;Classification;Communication;coping;design;effective intervention;effectiveness evaluation;eligible participant;Emergency department visit;Enrollment;Feeling suicidal;follow-up;Funding;Goals;Health;Health system;high risk;hospital readmission;Hospitalization;Hospitalized Adolescent;ideation;implementation barriers;implementation evaluation;implementation facilitators;implementation intervention;inpatient psychiatric treatment;inpatient service;Inpatients;Interruption;Intervention;Interview;Mediating;Medical center;meetings;Michigan;motivational enhancement therapy;multi-component intervention;National Institute of Mental Health;novel;novel strategies;operation;Outcome;Participant;patient population;Patient Recruitments;Patients;Pediatric Hospitals;Phase;Positioning Attribute;post-COVID-19;precision medicine;prevent;primary outcome;programs;Public Health;Randomized;recruit;Recurrence;reducing suicide;Reporting;Resources;response;Risk;Safety;secondary analysis;secondary outcome;Self Efficacy;Sequential Multiple Assignment Randomized Trial;Services;Severities;sex;Site;Statistical Study;suicidal;suicidal adolescent;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;System;Technology;technology intervention;Text Messaging;texting support;Time;Training;trial design;trial enrollment;Universities;Youth

PROJECT_TITLE: Adaptive intervention to prevent adolescent suicidal behavior following psychiatric hospitalization: A Sequential Multiple Assignment Randomized Trial

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Neurosciences

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project narrative The ability to sense osmolarity changes is vital for human health, and robust mechanisms are evolved to keep the osmolarity of body fluids within a narrow range. The knowledge gap in the molecular identities of osmosensors has greatly hindered our understanding of osmoregulation mechanisms. The proposed work aims to identify the first osmosensors in the animal kingdom, providing novel insights into the mechanisms of osmosensation, osmoregulation and related diseases.

PI_NAMEs: ZHANG, XINXING  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Address;Animals;avoidance behavior;Award;Behavioral;Biochemistry;Blood;Body Fluids;Brain;Caenorhabditis elegans;Calcium;career;Categories;Cell Culture Techniques;Cells;Chemicals;Cryoelectron Microscopy;design;Detection;Disease;drinking behavior;Electrophysiology (science);Elements;falls;Family;G-Protein-Coupled Receptors;Generations;Genetic;Genetic Screening;Health;Hearing;Homeostasis;Homologous Gene;Human;human disease;Image;In Vitro;in vivo;insight;interdisciplinary approach;Knowledge;Lead;Life;Liquid substance;Mammalian Cell;Mammals;mechanical force;Mediating;Mentors;Modality;Modeling;Molecular;Molecular Genetics;Monitor;mutant;Nature;Nematoda;Nervous System Trauma;neural;Neurons;novel;Organ;Organism;Osmolar Concentration;Osmoregulation;Osmosis;Phase;Photons;Physiological;post-doctoral training;Property;Proprioception;receptor;Regulation;Research;Research Personnel;Rodent;screening;Sensory;Sensory Receptors;sensory stimulus;Signaling Molecule;skill acquisition;Smell Perception;Stimulus;Structure;System;Taste Perception;Temperature;Testing;Thirst;Time;tool;Touch sensation;Training;TRP channel;Vision;Work

PROJECT_TITLE: Identification of novel osmosensing receptors in C. elegans


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative There are no proven therapies for single ventricle heart failure and the mechanisms involved in the transition to heart failure in this patient population are unknown. Despite the lack of mechanistic studies, phosphodiesterase-5 inhibitors (PDE5i) are widely used in this patient population. The results of this study will provide novel information regarding the transition to heart failure in the SV patient, and investigate the mechanisms through which PDE5i improve mitochondrial function in the failing SV heart.

PI_NAMEs: MIYAMOTO, SHELLEY DEANNE (contact);STAUFFER, BRIAN L;SUCHAROV, CARMEN C

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Acute;Adult;Age;Anatomy;Animal Model;biobank;Blood flow;Cardiac;Cardiac Myocytes;Cardiomyopathies;care outcomes;Childhood;Chronic;Clinical;clinical care;Clinical Trials;Common Ventricle;Complex;Congenital Abnormality;congenital heart abnormality;Data;Deacetylation;Development;Disease;Electron Spin Resonance Spectroscopy;Exercise;exercise capacity;experience;experimental study;Generations;Genetic;Goals;Guidelines;Heart;Heart Diseases;Heart failure;Heart Transplantation;Hematological Disease;honokiol;human tissue;Impairment;improved;improved outcome;Infant;inhibitor;inhibitor therapy;innovation;Institution;Investigation;Literature;Lung;Mediating;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;Muscle Cells;Myocardial;Myocardium;National Heart, Lung, and Blood Institute;Neonatal;new therapeutic target;novel;Operative Surgical Procedures;palliation;Palliative Surgery;patient population;Patients;Perioperative;Permeability;Pharmaceutical Preparations;phosphodiesterase V;Physiology;Population;Populations at Risk;Post-Translational Protein Processing;postnatal;pre-clinical;pressure;prospective;Protein Acetylation;Proteome;Publications;Publishing;Rattus;Reactive Oxygen Species;Recommendation;Research;Respiration;response;Risk;Series;Serum;Signal Transduction;sildenafil;Single ventricle congenital heart disease;Sirtuins;Specimen;Spirometry;targeted treatment;Techniques;Tissues;Transplantation;Treatment Failure;Ventricular

PROJECT_TITLE: Targeting Mitochondria in Single Ventricle Heart Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(05)]


ADMINISTERING_IC: DK

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative We have developed an innovative new enzyme-based therapeutic technology to shut down inflammation. As an injectable into the bloodstream, this new type of drug is showing great promise for the treatment of liver ischemia-reperfusion injury, which is a major clinical problem lacking treatment options.

PI_NAMEs: KESELOWSKY, BENJAMIN GEORGE (contact);ZARRINPAR, ALI

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Acute;Address;Anti-Inflammatory Agents;Antibodies;Antigens;Automobile Driving;Biological;Blood Circulation;Blood flow;Catalogs;Cell Death;cell injury;Cell Physiology;cell type;Cells;Chronic;Circulation;Clinical;clinical practice;Coupled;cytotoxicity;Data;Disease;Dose;drug action;Drug Kinetics;druggable target;Engraftment;Enzymes;Essential Amino Acids;extracellular;Formulation;Future;Goals;Half-Life;Homeostasis;Immune;Immune response;Immunocompromised Host;immunogenicity;Immunophenotyping;immunoregulation;Immunosuppression;implantation;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;Injectable;Injections;Injury;innovation;interest;intravenous administration;Ischemia;Kynurenine;Left;Liquid substance;Liver;Liver Dysfunction;Liver Failure;liver ischemia;Maximum Tolerated Dose;Mediator;Metabolic;Metabolism;Myocardial Infarction;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Organ;Organ failure;Outcome;Pathology;Pathway interactions;Pharmaceutical Preparations;Pharmacodynamics;Polyethylene Glycols;Positioning Attribute;preconditioning;preservation;Process;programs;prophylactic;Reperfusion Injury;restoration;side effect;Site;Sterility;Stroke;success;systemic toxicity;Technology;Therapeutic;tissue repair;Tissues;Toxic effect;Toxicology;Transplantation;Trauma;Tryptophan;Tryptophan 2,3 Dioxygenase;Tryptophan Metabolism Pathway;Vascular blood supply

PROJECT_TITLE: Directing Tryptophan Immunometabolism to Ameliorate Liver Ischemic-Reperfusion Injury

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative Streptococcus pneumoniae is a leading cause of community-acquired pneumonia and infectious death worldwide. Current vaccines are mainly based on the capsular polysaccharides and are limited in the range of coverage, emerging non-vaccine serotypes and antimicrobial resistance. The proposed study will define the effectiveness of a novel endolysin as a point of care therapeutic and its use as a mucosal vaccine proxy for development of serotype-independent protective immunity.

PI_NAMEs: GONZALEZ-JUARBE, NORBERTO  (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Address;Animal Model;Animals;Antibiotic Resistance;Antibiotics;Antibodies;Antibody Formation;Antibody Response;Antibody-mediated protection;Antigens;antimicrobial;Antimicrobial Resistance;Apoptosis;aspirate;Automobile Driving;Bacteremia;Bacteria;Bacterial Proteins;Bacteriophages;Benchmarking;Biochemical;Biochemistry;Biological;Biological Assay;Biophysics;Cell Death;Cell Death Induction;Cells;cellular development;Cessation of life;Child;Coculture Techniques;community acquired pneumonia;Country;Developing Countries;Development;Disadvantaged;Disease;Effectiveness;effectiveness evaluation;effectiveness testing;Elderly;endolysin;Enzymes;Epithelium;extracellular;Extracellular Matrix;Fatality rate;Generations;Goals;Gram-Positive Bacteria;Health;Health Care Costs;Human;Immunity;Immunize;immunogenic;Immunologic Techniques;Immunologics;In Vitro;in vivo;Individual;Inflammation;Lead;Lung;Lytic Phase;Macrophage;Mass Spectrum Analysis;member;Microbial Biofilms;Modeling;Molecular;mucosal vaccine;Mus;N-Acetylmuramoyl-L-alanine Amidase;Nasopharynx;Necrosis;next generation;Nose;novel;opportunistic pathogen;oral commensal;Oral mucous membrane structure;Organism;Otitis Media;Peptidoglycan;Pharyngeal structure;Phosphotransferases;Pneumococcal Colonization;Pneumococcal Infections;Pneumonia;point of care;Polymers;Polysaccharides;Population;Predisposition;prevent;Property;Proteins;Proteomics;Proxy;Research;Resistance;resistant strain;response;Role;Safety;Serotyping;single-cell RNA sequencing;Sinusitis;Specificity;Streptococcus pneumoniae;Streptococcus pneumoniae plY protein;sugar;Technology;Testing;Therapeutic;Tissues;tool;Toxic effect;Toxin;transcriptomics;Transgenic Mice;Vaccines;World Health Organization

PROJECT_TITLE: Endolysins as tools to eradicate pneumococcal biofilms and development ofprotective immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DDR-C(01)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Immunotherapy;Rare Diseases

ORG_CITY: BOSTON

ORG_DEPT: DENTISTRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative Oral cancer represents a significant societal burden. In this project, we propose to identify the key underlying causes of oral cancer by investigating changes in the chromatin environment brought about by an enzyme, lysine-specific demethylase 1 (LSD1). We anticipate that this study will increase knowledge about the biology of oral cancer, explore a synergistic combination of effective therapy, and lead to the development of novel treatment strategies for this pernicious disease.

PI_NAMEs: BAIS, MANISH  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Animal Model;anti-cancer research;anti-PD-L1 antibodies;anti-PD1 therapy;Attenuated;attenuation;Biology;Breast;cancer stem cell;carcinogenesis;Carcinoma in Situ;cell type;Cells;Cessation of life;Chromatin;Clinical;clinically relevant;Collaborations;connective tissue growth factor;Data;Development;Disease;Dysplasia;effective therapy;Environment;Enzymes;Epidermal Growth Factor Receptor;Epigenetic Process;epigenome;Epithelium;experience;Family Felidae;Future;Genetic;Goals;high risk;Human;IL-6 inhibitor;IL6 gene;Immune;immune checkpoint;in vivo;inhibitor;Interleukin-6;JAK2 gene;KDM1A gene;Keratin;Knockout Mice;Knowledge;Lead;Lesion;Leukoplakia;Malignant - descriptor;malignant mouth neoplasm;Malignant Neoplasms;malignant phenotype;Modification;mouse model;mouth squamous cell carcinoma;Mus;Neoplasms;Nivolumab;Normal tissue morphology;novel;Oral;Oral cavity;oral tissue;Pathologic;Pathway interactions;patient derived xenograft model;Patients;PD-1 inhibitors;pharmacologic;Phenotype;prevent;programmed cell death ligand 1;programmed cell death protein 1;programs;promoter;Proteomics;Publishing;Recurrence;Resistance;Sampling;Signal Induction;Signal Transduction;single-cell RNA sequencing;STAT3 gene;stem;stem cells;Testing;Therapeutic;therapy resistant;Time;Tissue Sample;Tongue;Topical application;Translations;treatment strategy;tumor progression;United States;Up-Regulation

PROJECT_TITLE: Mechanism of LSD1 Function and Its Therapeutic Application for Progressive Oral Malignancy

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: DETROIT

ORG_DEPT: BIOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE Bacteria are known to generally lack membrane-bound organelles and were assumed to be disorganized. However, we discovered that bacteria contain non-membrane bound organelles called “biomolecular condensates” which organize their biochemical pathways. Therefore, by determining the mechanisms of bacterial “biomolecular condensates” we could identify novel antibiotic targets to combat rising drug resistance.

PI_NAMEs: SCHRADER, JARED MICHAEL (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Antibiotics;Bacteria;Bacterial RNA;Binding;Biochemical Pathway;Biochemistry;Bioinformatics;Biology;Caulobacter crescentus;Cells;Characteristics;combat;Complex;Drug resistance;Enzymes;experimental study;In Vitro;in vivo imaging;Liquid substance;Location;Membrane;novel;Organelles;Organism;pathogen;Pathogenicity;Perception;Phase;Physical condensation;physical process;public health relevance;RNA Decay;Structure;Textbooks

PROJECT_TITLE: Biomolecular Condensates as Organizers of Bacterial RNA Biology

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE We study molecular signals underlying aortic valve patterning to identify disease factors involved in congenital aortic valve defects that may be used as potential therapeutic targets for intervention.

PI_NAMEs: ZHENG, DEYOU ;ZHOU, BIN  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: 3-Dimensional;Affect;Animal Model;Aorta;Aortic Aneurysm;aortic valve;aortic valve disorder;Aortic Valve Stenosis;Apoptosis;autocrine;bicuspid aortic valve;Birth;Candidate Disease Gene;Cardiac;Cardiac Myocytes;Cardiac Output;Cell Lineage;Cells;clinical subtypes;Congenital Heart Defects;Coronary;Cues;Defect;design;Development;Developmental Process;Disease;Disease Outcome;disorder prevention;Dissection;DNA Sequence Alteration;effective therapy;Embryo;Embryonic Development;Enhancers;Epithelial Cells;epithelial to mesenchymal transition;Event;experimental study;gene network;General Population;Genes;Genetic;genetic signature;Heart;Heart Valve Diseases;Heterogeneity;Human;human model;Immunofluorescence Immunologic;In Situ Hybridization;in vivo;Individual;Inherited;insight;International;Intervention;Knock-out;Left;Location;Mediating;Medicine;Mesenchymal;Modeling;Molecular;mouse model;Mus;mutant;Mutation;notch protein;NOTCH1 gene;Operative Surgical Procedures;Pathogenesis;Patients;Pattern;PDGFB gene;PDGFRA gene;Phenotype;Platelet-Derived Growth Factor;receptor;response;Role;Severity of illness;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;SOX17 gene;spatiotemporal;Testing;Therapeutic;therapeutic target;transcription factor

PROJECT_TITLE: Molecular signaling in aortic valve development and congenital aortic valve defect

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Stroke

ORG_CITY: CHARLESTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PI_NAMEs: DERDEYN, COLIN PIETER;ELM, JORDAN J. (contact);FIORELLA, DAVID J;JOVIN, TUDOR G.;KHATRI, POOJA ;MISTRY, EVA ;MOCCO, J DUFFY;NOGUEIRA, RAUL GOMES;SAVER, JEFFREY L;SIDDIQUI, ADNAN

PROGRAM_OFFICER_NAME: AFZAL, MARIAM MASHEEB

PROJECT_TERMS: Acceleration;Acute;acute care;acute stroke;Address;Agreement;Anterior;authority;Bayesian Modeling;Biometry;care systems;Caring;Categories;Catheters;Circulation;Clinical;Clinical Trials;Communities;Consult;Data;Data Coordinating Center;data exchange;data platform;design;Devices;disability;Eligibility Determination;Emergency Medicine;endovascular thrombectomy;Enrollment;Epidemiology;epidemiology study;Exclusion Criteria;Generations;Goals;hospital care;Hospitals;Image;improved;individual patient;Infrastructure;innovation;Institutional Review Boards;interest;Intervention;Ischemia;Ischemic Stroke;Maps;Medical;Methodology;Modeling;multidisciplinary;National Institute of Neurological Disorders and Stroke;Nature;neuroprotection;novel;optimal treatments;Outcome;participant enrollment;patient subsets;Patients;Population;Positioning Attribute;primary endpoint;Procedures;Protocols documentation;Randomized;Randomized, Controlled Trials;Registries;Reperfusion Injury;Reperfusion Therapy;Research Design;Research Personnel;Sedation procedure;simulation;Site;South Carolina;Speed;Stroke;stroke neurology;stroke patient;stroke therapy;System;Techniques;Technology;Terminology;Testing;Therapeutic;treatment strategy;trial design;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: StrokeNet Thrombectomy Endovascular Platform (STEP)


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: ITHACA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative (Overall) Increasing faculty diversity in the biological, biomedical, and health sciences will contribute to the diversity of the academy, and future generations of the STEM workforce. Cornell University aims to increase the number of minoritized faculty in the biological, biomedical, and health sciences through establishing an NIH FIRST Program at Cornell University. Cornell FIRST will support the hiring and retention of 10 new assistant professors from groups underrepresented in their fields, while transforming institutional climate into a culture of inclusive excellence.

PI_NAMEs: AUGUST, AVERY  (contact);KOTLIKOFF, MICHAEL I.

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Academy;Advocacy;Area;Biological;Biology;career;career development;Climate;cohort;college;Complex;Development;early-career faculty;Environment;Equity;Evaluation;evidence base;Faculty;faculty support;Fostering;Future Generations;health equity;Health Sciences;Individual;Infection;Institution;Institutional Policy;Institutionalization;Interdisciplinary Study;interest;Learning;Mentors;Minority;Mission;novel;organizational climate;Positioning Attribute;Privatization;professor;programs;Research;Science;STEM career;success;System;Teacher Professional Development;Testing;Underrepresented Populations;United States National Institutes of Health;Universities;Wages

PROJECT_TITLE: Cornell FIRST


ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE In order to colonize and inhabit the human microbiome, both pathogenic and commensal microbes must adapt to withstand complex stressful conditions, such as oxygen and nutrient limitation. Investigation into how the interaction of stresses influence microbial evolution is important for a deeper understanding of the infectious disease process and can lead to future targets for antimicrobial therapies and novel approaches to disease prevention.

PI_NAMEs: BEHRINGER, MEGAN GRACE (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Using Experimental Evolution to Evaluate Environmental Effects on Microbial Mutation and Adaptation


ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Radiation therapy for cancer can kill tumor cells and also activate the immune system, but these benefits are limited by collateral damage to normal tissues. We propose to evaluate the anti-tumor and immunological effects of extremely fast (“FLASH”) radiation therapy, which will be achievable clinically by a new medical linear accelerator technology that we are developing (called PHASER). These experiments are expected to show that FLASH is both safer and more effective against cancer than conventional radiation.

PI_NAMEs: ENGLEMAN, EDGAR G.  (contact);LOO, BILLY W

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Ablation;Abscopal effect;Acceleration;Address;Algorithms;Animals;anti-PD-1;anti-PD1 antibodies;anti-tumor immune response;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Antigens;antitumor effect;B-Lymphocytes;Blocking Antibodies;Brain;Cancer Model;cancer radiation therapy;cancer type;Cell Death;Cells;checkpoint therapy;Clinical;Clinical Trials;Cognition;conventional dosing;Cross Presentation;Data;Dendritic Cells;Disease;Distant;Dose;Dose Rate;Exhibits;expectation;Experimental Models;experimental study;Fibrosis;fractionated radiation;Gastrointestinal tract structure;Human;Immune;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune response;Immune system;immunogenic;Immunologics;Immunotherapy;in situ vaccination;Inflammatory;Interferon Type I;intestinal crypt;irradiation;Knockout Mice;Linear Accelerator Radiotherapy Systems;Lung;lymphocyte trafficking;Malignant Neoplasms;Maximum Tolerated Dose;Mediating;Medical;Modality;Modeling;Molecular;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;neuroinflammation;next generation;Normal tissue morphology;organ injury;patient derived xenograft model;Patients;PD-1 blockade;pharmacologic;pre-clinical;Primary Neoplasm;Radiation;Radiation Dose Unit;Radiation therapy;receptor;Research Design;response;Role;Safety;subcutaneous;Syndrome;synergism;System;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Therapeutic;Therapeutic Effect;Therapeutic Index;Tissues;Toxic effect;tumor;tumor eradication;tumor growth;Tumor Immunity

PROJECT_TITLE: Effects of FLASH Radiation on Cancer and the Immune Response

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Physical Activity;Physical Rehabilitation;Rehabilitation;Rheumatoid Arthritis

ORG_CITY: CHAPEL HILL

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE. Disability is common in adults with rheumatoid arthritis. Rehabilitation and exercise can improve disability but are not well integrated into routine care. The proposed study is necessary to develop a model to integrate rehabilitation and exercise guidance into routine care with the goal of preserving valued activities in life for adults with rheumatoid arthritis.

PI_NAMEs: THOMA, LOUISE M. (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Adult;American;Anti-Rheumatic Agents;Autoimmune Diseases;Award;Canada;career development;Caring;Clinical;clinical research site;Clinical Trials;cohort;Collection;Country;design;Development;Development Plans;disability;disability risk;Disease;Early identification;effectiveness testing;Exercise;exercise intervention;Exercise Therapy;Fatigue;feasibility testing;Feedback;follow-up;functional decline;Germany;Goals;Health Services Research;Impairment;improved;Interview;joint destruction;joint inflammation;K-Series Research Career Programs;Knowledge;Learning;Life;Measurement;Medication Management;Mentors;Methodology;Modeling;Musculoskeletal Diseases;Outcome;Pain;participant retention;Patient Recruitments;Patients;pharmacologic;Phase;Physical Exercise;physical impairment;physical therapist;Physical therapy;Pilot Projects;pilot test;pilot trial;Preparation;preservation;Process;prospective;Provider;Questionnaires;randomized trial;Recommendation;Regimen;Rehabilitation therapy;Research;Research Proposals;Rheumatism;Rheumatoid Arthritis;rheumatologist;routine care;Sampling;screening;Screening procedure;Screening Result;Specificity;Structure;Surveys;therapy development;Time;tool;Training;treatment guidelines;United States;Value of Life

PROJECT_TITLE: Helping Adults with RA PREVAIL: Developing a model to Preserve Valued Activities In Life

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Cancer;Clinical Research;Comparative Effectiveness Research;Digestive Diseases;Esophageal Cancer;Health Services;Prevention;Rare Diseases

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

PHR: PROJECT NARRATIVE Barrett’s esophagus (BE) is a prevalent disease and can be effectively treated to prevent esophageal adenocarcinoma (EAC). The goal of this proposal is to promote earlier detection and prevention of EAC through the implementation of shared decision making and patient-centered approaches to improve BE outcomes.

PI_NAMEs: ELURI, SWATHI  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Ablation;administrative database;Affect;American;Anxiety;Award;Awareness;Barrett Esophagus;Biology;cancer risk;care delivery;career;career development;Caring;Clinical;Clinical Investigator;Clinical Sciences;cognitive interview;collaborative environment;comparative effectiveness;Comparative Effectiveness Research;comparative effectiveness study;Cost of Illness;Data;Databases;Decision Aid;design;Detection;Development;Digestive System Disorders;Disease;Dysplasia;Early Diagnosis;Eligibility Determination;Endoscopy;Ensure;Environment;Epidemiology;Esophageal Adenocarcinoma;Esophageal Diseases;experience;Faculty;Fostering;Foundations;Funding;Funding Opportunities;Future;Gastroenterology;gastrointestinal;Generations;Goals;High grade dysplasia;high risk;higher education;implementation science;improved;Incidence;Institution;instrument;interest;International;Interview;Knowledge;large datasets;Malignant Neoplasms;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Modality;North Carolina;Online Systems;Outcome;Outcome Measure;Pathway interactions;patient oriented;patient oriented research;Patient Outcomes Assessments;patient population;Patient-Centered Care;patient-clinician communication;Patient-Focused Outcomes;Patients;personalized care;Phase;Physicians;preference;prevent;Prevention;psychosocial;Publications;Qualitative Research;Quality of life;Randomized, Controlled Trials;Research;research and development;Research Methodology;Research Personnel;Research Project Grants;Scientist;screening;shared decision making;skill acquisition;skills;Standardization;Survival Rate;Symptoms;Teacher Professional Development;Testing;tool;Training;Translational Research;Treatment outcome;United States;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Universities

PROJECT_TITLE: Approaches and Outcomes of Shared Decision-making and Patient Centered Care Delivery in Barrett's Esophagus

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK(M1)-1-C]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BETHESDA

ORG_NAME: IMMUNOBLUE, LLC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it could make available an effective and safe T cell therapy for glioblastoma (GBM), the most common primary brain tumor, with a poor relative five-year survival rate of 7.5%. Successful completion of this Phase I project will advance insights into the scientific merit and feasibility of utilizing nanoparticle-based photothermal therapy to develop autologous tumor-specific T cells for adoptive cell therapy, in patient-derived models of GBM in vitro and in vivo. Further, it will provide the impetus to achieve our long-term goal of translating our approach as an adjuvant therapy post-surgery for patients with GBM.

PI_NAMEs: FERNANDES, ROHAN ;SWEENEY, ELIZABETH E (contact)

PROGRAM_OFFICER_NAME: ZANE, LINDA KARINE

PROJECT_TERMS: Address;Adjuvant Therapy;Adoptive Cell Transfers;Allogenic;Animals;Antigen Presentation;Antigen Targeting;Antigens;Astrocytes;Autologous;Autologous Dendritic Cells;Automobile Driving;autoreactivity;Back;Beds;Blood;CD276 gene;Cell Culture Techniques;Cell Line;Cell secretion;Cells;chemokine;chimeric antigen receptor T cells;Clinical Research;Coculture Techniques;commercialization;cytokine;Cytolysis;cytotoxicity;Data;Dendritic Cells;design;Dose;efficacy evaluation;efficacy testing;Engineering;Ensure;Excision;Foundations;Generations;Glioblastoma;Glioma;Goals;Health;Human;immunogenic cell death;Implant;improved;In Vitro;in vivo;in vivo Model;Infusion procedures;insight;Institutional Review Boards;Interferon Type II;Lasers;Ligands;manufacture;Measures;Mediating;Modeling;Mus;nanoparticle;neoplastic cell;novel;novel therapeutics;Ommaya Reservoir;Operative Surgical Procedures;patient derived xenograft model;Patient-Focused Outcomes;Patients;Peripheral Blood Mononuclear Cell;Phase;phase 1 study;Phenotype;photothermal therapy;preferentially expressed antigen in melanoma;Primary Brain Neoplasms;Prognosis;Prussian blue;Public Health;Publishing;Reproducibility;Research;response;S-Phase Fraction;Safety;Sampling;scale up;Small Business Technology Transfer Research;Source;standard of care;Survival Rate;T cell therapy;T-Lymphocyte;targeted treatment;Testing;therapy design;therapy development;Toxic effect;Translating;Treatment Protocols;tumor;Tumor Antigens;Tumor Cell Line;Tumor Expansion;tumor growth;tumor microenvironment;Up-Regulation;uptake;Xenograft Model

PROJECT_TITLE: Engineered Glioblastoma-specific T cells using Immunostimulatory Photothermal Nanoparticles

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-R (12)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Infectious Diseases;Lung;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE (of parent award SUPPLEMENT is admin only) These findings will reveal key mechanisms (IL-5, HMGB1, and TREM2) in the Th2 Lung-Brain Axis responsible for how the Th2 pulmonary response, A. versicolor, and the peripheral immune compartment affect the brain and augment AD processes, identifying key opportunities to mitigate AD neuropathology.

PI_NAMEs: BLOCK, MICHELLE L (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acquired disability;Administrative Supplement;Affect;Agonist;Air Pollution;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Amyloid beta-Protein;amyloid pathology;Antibodies;Antibody Therapy;Aspergillus;Asthma;Attenuated;Autoimmune;Automobile Driving;beta amyloid pathology;Brain;C57BL/6 Mouse;Categories;Cells;Central Nervous System Diseases;Circulation;Cognition;cohort;Computer software;Data;Dementia;Development;Diagnosis;disabled;Disease Marker;Disease Progression;Elderly;Environment;Environmental Exposure;Environmental Risk Factor;eosinophil;Etiology;experimental study;Exposure to;frontal lobe;Genetic;Genetic Transcription;HMGB1 gene;Human;Human Resources;Immune;immune cell infiltrate;Immune response;Indoor environment;Inhalation;Inhalation Exposure;inhibiting antibody;inhibitor;Interleukin-5;Intervention;Link;loss of function;loss of function mutation;Lung;Lung immune response;Measures;Memory;Microglia;Modification;Molds;Morphology;mouse model;Mus;Mutation;Myeloid Cells;Neurites;Neurodegenerative Disorders;Neuroimmune;neuroinflammation;neuropathology;parent grant;parent project;Pathogenesis;Pathology;Peripheral;Physiology;pollutant;Process;Pulmonary Inflammation;Pulmonary Pathology;receptor;Research;Research Personnel;Respiratory Disease;response;Role;Senile Plaques;Software Tools;success;Testing;TLR4 gene;TREM2 gene

PROJECT_TITLE: The Role of Aspergillus versicolor and the Th2 Lung-Brain Axis in Alzheimer's Disease-like Neuropathology

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: NEWARK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Adolescence is an important period in social and cognitive development, and social isolation during this developmental stage has long-lasting impacts on physical and mental health. Value-based decision making, or how we make decisions about the costs and benefits of alternative options, is a crucial aspect of daily life. This project will uncover how adolescent social isolation alters these complex decision-making behaviors in adulthood, as well as the underlying neural circuitry.

PI_NAMEs: HOLLY, ELIZABETH N. (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;Automobile Driving;Award;Behavior;Behavioral;career;cognitive development;Complex;Computer Models;Corpus striatum structure;cost;Costs and Benefits;COVID-19;Data;Decision Making;Development;Electrophysiology (science);Ensure;Faculty;Female;Foundations;Goals;Holly;in vivo;Laboratory Research;Life;male;Medial;Mental Health;Mentored Research Scientist Development Award;Mentorship;Mus;neural;neural circuit;neural network;Outcome;Output;physical conditioning;Physiological;Positioning Attribute;Prefrontal Cortex;Research;Rewards;school closure;Social Development;Social Interaction;Social isolation;stay-at-home order;Synapses;Techniques;tenure track;Testing;Training;Work

PROJECT_TITLE: Continuity Supplement: K01 MH127306

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Lupus;Prevention;Telehealth

ORG_NAME: TUFTS MEDICAL CENTER

PHR: PROJECT NARRATIVE While advances in the treatment of systemic lupus erythematous (SLE), a chronic autoimmune condition, have reduced mortality, quality of life for individuals with the disease remains poor, largely driven by fatigue. SLE- related fatigue is often resistant to medical therapy and studies suggest biologic, behavioral, and psychosocial drivers. The proposed research project will develop and pilot test a peer coaching intervention to holistically address this critical unmet need of patients with SLE.

PI_NAMEs: KASTURI, SHANTHINI  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Attention;Autoimmune Diseases;Award;behavior change;Behavior Therapy;Behavioral;behavioral clinical trial;Behavioral trial;Biological;career;Chronic;Clinical Trials Design;Conduct Clinical Trials;Control Groups;design;Development;Dimensions;Disease;Disease Outcome;Education;efficacy outcomes;efficacy testing;efficacy trial;Enrollment;Etiology;Evaluation;evidence base;experience;Fatigue;feasibility testing;Future;Goals;Health behavior;health related quality of life;Health Technology;impaired productivity;improved;improved outcome;Individual;Informatics;Institution;Intervention;Intervention Trial;Knowledge;Lupus;Measurement;Mediator;Medical;Medical center;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;method development;Methodology;mHealth;mhealth interventions;Mobile Health Application;mortality;motivational enhancement therapy;multi-site trial;Nonpharmacologic Therapy;Observational Study;Outcome Measure;patient engagement;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;peer;peer coaching;Persons;physical inactivity;pilot test;pilot trial;primary outcome;programs;prospective;psychologic;Psychology;psychosocial;Psychosocial Assessment and Care;Quality of life;Randomized;Randomized, Controlled Trials;Refractory;Research;Research Methodology;Research Personnel;Research Project Grants;Resistance;Rheumatism;rheumatologist;Scientist;secondary outcome;Self Determination;Self Efficacy;Self Management;skills;success;Symptoms;Systemic Lupus Erythematosus;Techniques;Testing;theories;therapy design;therapy development;tool;Training;treatment as usual;Unemployment;United States National Institutes of Health;user centered design;Validation;Work

PROJECT_TITLE: Targeted Peer Coaching to Reduce Fatigue in Lupus: A Patient-Centered Behavioral Intervention


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE People who inject drugs (PWID) are face higher risk of HIV, opioid overdose death, and other sequelae of injection drug use, yet they are the least likely to access effective tools to prevent and treat these conditions. Interventions to improve access must address the fragmented nature of healthcare, burdensome paperwork, and stigma in healthcare settings. We propose to test the feasibility, acceptability, and preliminary effect of an intervention that co-locates HIV-related telehealth services in syringe exchange programs in order to improve PWID access to life-saving interventions.

PI_NAMEs: SMITH, M KUMI (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Advocate;AIDS prevention;Back;Black race;Blood;care seeking;Caring;Case Manager;Client;Clinic;Clinical;clinical care;Communicable Diseases;Communities;community advisory board;community engagement;Complex;Computerized Medical Record;Confusion;Consolidated Framework for Implementation Research;Continuity of Patient Care;cost;cost effective;COVID-19 pandemic;Data;data sharing;design;Devices;digital health;Disease Outbreaks;Disparity;Distress;Effectiveness;Eligibility Determination;Enrollment;Ensure;Ethnic Origin;evidence base;Evidence based intervention;experience;Face;feasibility testing;financial incentive;follow-up;Frequencies;Geographic Locations;Harm Reduction;Health;health care settings;Health Personnel;Health Services;Healthcare;Healthcare Systems;Hepatitis C Therapy;Hepatitis C virus;high risk;HIV;HIV disparities;HIV risk;Improve Access;improved;Indigenous;Infrastructure;Injecting drug user;injection drug use;innovation;insight;Insurance;integrated care;interest;Internet;Intervention;intervention effect;Interview;knowledge base;Life;marginalized community;Measures;Medicaid;medication for opioid use disorder;Minnesota;Modeling;mortality;Nature;Needle-Exchange Programs;opioid mortality;opioid overdose;opioid use disorder;Overdose;overdose risk;patient navigator;Patients;Persons;Population;pre-exposure prophylaxis;prevent;Primary Care;Privacy;Privatization;Procedures;Process;programs;Protocols documentation;Provider;Public Health Informatics;Race;remote delivery;Reporting;Research;Resources;Risk;Running;Rural;Rural Population;Schedule;service intervention;service providers;Services;sharing platform;Site;social;social stigma;Social Work;structural determinants;substance use;System;Technology;telehealth;Telemedicine;Testing;therapy design;Time;tool;Training;Transportation;uptake;urban area;Urban Population;Visit;web portal;Withdrawal;Work

PROJECT_TITLE: Comprehensive Telehealth at Syringe Service Programs to Engage People Who Inject Drugs into the HIV Care Continuum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-Y (03)]


ORG_CITY: SAN FRANCISCO

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The initiating causes of psoriasis and psoriatic arthritis as well as the link between skin and joint disease are still uncertain and improved knowledge of these factors may lead to novel therapies or aid with diagnosis. Multiple studies have shown that patients with variants of the A20 (Tnfaip3) gene have a higher susceptibility to psoriasis and psoriatic arthritis. This proposal aims to understand how defects in A20 can initiate the inflammatory processes that ultimately lead to psoriatic skin and joint disease.

PI_NAMEs: RAZANI, BAHRAM  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 3-Dimensional;A20 protein;Adult;Advisory Committees;Affect;Anatomy;Antigens;Arthritis;arthropathies;Automobile Driving;Binding;Binding Proteins;Biology;career;career development;Cells;Cellular Immunology;Chronic small plaque psoriasis;Complex;Cutaneous;cytokine;Cytokine Network Pathway;Data;Defect;Development;Development Plans;Diagnosis;Digit structure;Disease;Distal;early detection biomarkers;Early Diagnosis;Educational workshop;Epidermis;Epithelium;Evolution;experimental study;fascinate;Foundations;Functional disorder;Genes;Genetic Polymorphism;Genomics;Germ Lines;Goals;Histologic;Human;Human Characteristics;IL17 gene;Immune;immune cell infiltrate;Immune signaling;Immunologist;Immunology;improved;in vivo;Inflammation;Inflammatory;Inflammatory Infiltrate;Inflammatory Response;joint destruction;joint inflammation;Joints;keratinocyte;keratinocyte differentiation;Knock-in;Knowledge;Leadership;Learning;Link;Location;Mentors;Mentorship;Modeling;Molecular;mouse model;Mouse Strains;multidisciplinary;Mus;mutant;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nature;new therapeutic target;NF-kappa B;novel;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;patient subsets;Patients;Phase;Physicians;Play;Population;Positioning Attribute;Predisposition;prevent;Process;programs;Protein Biochemistry;Proteins;Psoriasis;Psoriatic Arthritis;Publishing;Research;Research Personnel;Rheumatology;Role;Scientist;Series;Signal Pathway;Signal Transduction;skills;Skin;skin disorder;Statistical Data Interpretation;symposium;T-Lymphocyte;therapeutic biomarker;Tissues;TNF gene;transcriptomics;Tumor Necrosis Factor Receptor;two-dimensional;Ubiquitin;United States;Variant;Zinc Fingers

PROJECT_TITLE: Restriction of psoriatic skin and joint disease by A20


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Childhood Obesity;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Nutrition;Obesity;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative NAFLD is the most common chronic liver disease in pediatrics, affecting 30% of obese children and adolescents. The key question that we plan to address here is: what are the main determinants of NAFLD development in obese youth? We will leverage differences in the propensity to develop NAFLD between NHB and Hispanics to learn about the mechanisms underlying this condition.

PI_NAMEs: SANTORO, NICOLA  (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Acids;Address;Adolescent;Adolescent obesity;Adult;Affect;Age;Black Populations;Black race;Body mass index;Carbohydrates;cardiometabolism;Child;chronic liver disease;Cirrhosis;Citric Acid Cycle;Clinical;Clinical assessments;Continuous Glucose Monitor;Data;Death Rate;Deuterium Oxide;Development;diagnostic criteria;Dietary Carbohydrates;Disease;Disparity;Dyslipidemias;early onset;end stage liver disease;Enrollment;ethnic difference;Ethnic Origin;Ethnic Population;Etiology;experience;Fasting;fasting plasma glucose;Fatty acid glycerol esters;Fatty Liver;Fibrosis;follow-up;Functional disorder;Funding Opportunities;Gender;Glucose;glucose sensor;Glycolysis;Hepatic;High Prevalence;Hispanic;Hispanic Populations;Individual;insight;Insulin Resistance;intrahepatic;Kinetics;Learning;Life;lipid biosynthesis;Literature;Liver;Liver diseases;liver injury;Magnetic Resonance Imaging;Malignant neoplasm of liver;mathematical model;Measures;Metabolic;Methods;Morbid Obesity;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;Not Hispanic or Latino;novel;novel therapeutic intervention;Nutritional;Obesity;obesity in children;OGTT;Onset of illness;Pathogenesis;Pathogenicity;Pathologic;pediatric non-alcoholic fatty liver disease;Pediatrics;Periodicity;Plasma;Play;Predisposition;Probability;programs;Propionates;Race;recruit;Reporting;response;Retrospective Studies;Risk Factors;Role;Severity of illness;stressor;System;Testing;Time;Triglycerides;Youth

PROJECT_TITLE: Pathophysiologic mechanisms leading to intrahepatic fat accumulation in obese youth

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative Unlike in other malignant solid tumors, state-of-the-art immune checkpoint inhibition has failed to provide therapeutic benefits in patients with glioblastoma to data primarily due to its notoriously immunosuppressive nature. Molecular TGFβ trap would counter the tumor immunosuppression and thus rescue the effectiveness of checkpoint inhibition, but a series of challenging biological barriers preclude widespread and uniform delivery of TGFβ trap to the brain tumor. We here propose to develop and evaluate human protein nanocage- based formulation capable of overcoming multiple delivery barriers, thereby providing efficient and uniform TGFβ blockade in brain tumors to ultimately enhance therapeutic efficacy of clinically-used checkpoint inhibitors.

PI_NAMEs: LIM, MICHAEL ;SUK, JUNG SOO  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: 3-Dimensional;Adhesives;Affinity;aggressive therapy;Allografting;Antibodies;Area;Binding;Biodistribution;Biological;Blood;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier penetration;Brain;Brain Glioblastoma;Brain Neoplasms;brain tissue;Cells;Cellular Spheroids;checkpoint inhibition;Chimeric Proteins;Circulation;Clinical;clinical efficacy;Clinical Research;Clinical Trials;clinically relevant;Data;design;Dose;Drug Kinetics;Effectiveness;Endowment;Engineering;Exhibits;Extracellular Matrix;Extravasation;Ferritin;fighting;Formulation;Genes;Glioblastoma;Glioma;Human;human model;Hybrids;Hypoxia;Immune;Immune checkpoint inhibitor;Immune system;Immunocompetent;Immunologic Memory;immunoregulation;Immunosuppression;Immunotherapy;In Vitro;in vivo;inhibitor;innovation;Lead;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Masks;Maximum Tolerated Dose;Measurable;Mediator;Molecular;mouse model;Mus;nanocage;nanoengineering;Nature;optimism;Outcome;patient derived xenograft model;Patients;Penetration;Performance;Physiological;Pilot Projects;Play;Polyethylene Glycols;Population Distributions;pre-clinical;Pre-Clinical Model;preclinical study;Primary Brain Neoplasms;Probability;programmed cell death protein 1;Property;Proteins;prototype;Recurrence;Recurrent tumor;Refractory;Reporting;Role;Safety;seal;self assembly;Series;Signal Transduction;Solid Neoplasm;Spatial Distribution;standard of care;success;Surface;TFRC gene;TGFB1 gene;Therapeutic;therapeutic development;Therapeutic Effect;Tissues;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Treatment Efficacy;tumor;tumor hypoxia;tumor microenvironment;Tumor Promotion;Tumor Tissue;tumor-immune system interactions;uptake;Variant;Xenograft procedure

PROJECT_TITLE: Nanocage-based systemic delivery of TGFb trap for immunomodulation of brain neoplasms


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Contact PD/PI: YASSA, MICHAEL PUBLIC HEALTH NARRATIVE Anhedonia is a transdiagnostic symptom of multiple psychiatric disorders, including depression, schizophrenia and post-traumatic stress disorder, which are linked with increasingly high levels of economic burden related to substantial health care costs and unemployment. Anhedonia is independently associated with substantially increased risk of suicide, treatment resistance and reduced quality of life, yet its biological basis remains elusive. We will use computational models of behavior and cutting-edge neuroimaging techniques in combination with artificial intelligence approaches to biologically define anhedonia, with the ultimate goal of improving clinical practice for anhedonia through biologically informed clinical decision-making. Project Narrative

PI_NAMEs: THAYER, JULIAN F.;YASSA, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Anhedonia;Artificial Intelligence;Behavior;Behavioral;Biological;biomarker validation;Brain;Clinical;clinical decision-making;clinical practice;cognitive system;Computer Models;Decision Making;Diagnostic;Disease;Economic Burden;Episodic memory;experience;Functional Magnetic Resonance Imaging;Goals;Health Care Costs;improved;Intervention;Learning;Libraries;Link;Major Depressive Disorder;mathematical model;Measures;Memory;Mental Depression;Mental disorders;multimodality;Neurobiology;neuroimaging;neuromechanism;novel;Patient Self-Report;pleasure;Positive Valence;Post-Traumatic Stress Disorders;predictive marker;preservation;Prevention;Psychiatry;Psychological reinforcement;Public Health;Quality of life;rapid growth;Regulation;Research;Research Domain Criteria;Resolution;reward circuitry;reward processing;Rewards;Schizophrenia;Stimulus;suicidal risk;Symptoms;Techniques;Testing;therapy resistant;tool;Unemployment

PROJECT_TITLE: Testing a Memory-Based Hypothesis for Anhedonia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: PROJECT NARRATIVE Alzheimer’s disease is a major public health concern that continues to increase in severity given the aging population. It is also a condition that disproportionately affects minority populations, who have reduced access to healthcare and may have distinguishable risk factors including cerebrovascular risk. The goal of this project is to establish the role of cerebrovascular injury and dysfunction in the pathophysiology of preclinical Alzheimer’s and develop individualized imaging-based cerebrovascular profiles that predict memory decline across racially and ethnically diverse populations.

PI_NAMEs: YASSA, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Adverse event;Affect;Age Years;aging population;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Award;Biological Markers;Black Populations;Black race;Blood Vessels;brain dysfunction;Brain imaging;Brain Injuries;Cardiovascular Diseases;cerebrovascular;Chronic;Clinical Research;Cognitive;cohort;Complement;Deterioration;Development;digital;ethnic disparity;ethnic diversity;Ethnic Population;Etiology;Exclusion;follow up assessment;Functional disorder;Future;Goals;Health;health care availability;Hippocampus;Hispanic;Hispanic Populations;Image;Impaired cognition;Infrastructure;Injury;innovation;Intervention;Latino;Life Style;Magnetic Resonance Imaging;medial temporal lobe;Memory;Memory Loss;Minority Groups;Minority Recruitment;modifiable risk;neural;Neuronal Dysfunction;Neuropsychological Tests;non-demented;novel;novel marker;older adult;Participant;Pathogenesis;Patients;Pattern;Population;Population Heterogeneity;Positron-Emission Tomography;pre-clinical;Predisposition;Prevalence;Public Health;racial disparity;racial diversity;racial population;Recording of previous events;recruit;Resolution;Risk;Risk Factors;Role;Sampling;Severities;social health determinants;Stroke;structural determinants;Structure;tau aggregation;tau Proteins;Vascular Dementia;Vascular Diseases

PROJECT_TITLE: Assessing the role of cerebrovascular brain injury and dysfunction in Alzheimer’s disease pathogenesis in the BEACoN Cohort

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE  Olfactory dysfunction is often a first symptom of several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. A better understanding of the basic neural circuitry and functional properties of the olfactory system may provide clues to the etiology of these diseases, as well as potential diagnostic mechanisms.

PI_NAMEs: ZAK, JOSEPH DONALD (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: academic preparation;Acute;Alzheimer's Disease;Animals;Area;awake;Award;Axon;Back;Behavioral;Brain;calcium indicator;Cells;Central Nervous System;Chicago;Classification;Complex;Complex Mixtures;Detection;Development;Diagnostic;Disease;Environment;Etiology;experience;experimental study;Feedback;Future;Genetic;Goals;granule cell;Illinois;in vivo;Individual;innovation;insight;Interneurons;Ion Channel Gating;Laboratories;Learning;light gated;Measurement;Measures;Mediating;Modality;Modification;multiphoton microscopy;Mus;nerve supply;neural circuit;Neurodegenerative Disorders;Neurons;Neurosciences;novel;novel strategies;Odors;olfactory bulb;Olfactory dysfunction;Olfactory Pathways;Optics;optogenetics;Outcome;Outcome Study;Output;Parkinson Disease;Pattern;Phase;Physiological;piriform cortex;Play;Population;Positioning Attribute;postsynaptic;Process;programs;Property;response;Rewards;Role;Scheme;Sensory;sensory input;sensory stimulus;sensory system;Shapes;Site;Stimulus;Symptoms;Synapses;Technical Expertise;Testing;Training;Universities;Update;Vision;Weight;Work

PROJECT_TITLE: Learning-mediated plasticity in cortical feedback projections to the olfactory bulb

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: TS

IC_NAME: AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE / RELEVANCE The proposed research seeks to identify environmental risk factors for amyotrophic lateral sclerosis (ALS) in military veterans and our hypothesis is that the presence, concentration, spatial distribution and/or combination of persistent toxicants (toxic metals/elements, metal and metalloid nanoparticles, dioxins and polycyclic aromatic hydrocarbons) from service-linked exposures will be higher/different in brain tissue from Veterans Affairs (VA) subjects with ALS, as compared to controls without neurodegenerative illness. We also seek to identify mechanisms involved with metal and toxin exposure using a spatial-omics approach that combines single cell RNA sequencing and spatial gene profiling with our metal / NPs profiles. Potential impacts include reducing toxic exposures in veterans and the broader population as a whole, and inspiring new approaches to therapy.

PI_NAMEs: STOMMEL, ELIJAH W (contact)

PROJECT_TITLE: RFA-TS-24-010: Persistent Environmental Toxicants in Veteran CNS Tissue: Identifying Exposures Determining Higher ALS Risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZTS1 TQD (10)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: The goal of this U01 application is twofold: firstly, to test three different novel vaccine platforms against Kaposi's sarcoma-associated herpesvirus infection, and secondly, to develop chimeric Murine Herpesvirus 68 carrying the replacement of KSHV glycoprotein (MHV68-K-G) as a surrogate challenge virus for testing the efficacy of KSHV vaccines in an in vivo mouse model.

PI_NAMEs: JUNG, JAE U (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Address;Adverse effects;Affect;Africa South of the Sahara;Animal Model;Antibody Response;Antigens;antiretroviral therapy;Area;Attention;Bacterial Artificial Chromosomes;Basic Science;chronic infection;Codon Nucleotides;Development;Disease;effectiveness evaluation;efficacy testing;Engineering;Exhibits;experience;flexibility;Generations;Genes;Genetic;Glycoproteins;Goals;Health;Healthcare;Herpesviridae;Herpesviridae Infections;Herpesvirus Vaccines;high risk;HIV;HIV Infections;Human;Human Herpesvirus 8;Iatrogenic Kaposi's Sarcoma;Immune response;Immunity;Immunocompromised Host;immunogenicity;In Vitro;in vivo;in vivo Model;Individual;Infection;Infrastructure;interest;Kaposi Sarcoma;Link;lipid nanoparticle;Measles virus;Measures;Messenger RNA;Modeling;mouse model;mRNA lipid nano particle vaccine;Mumps virus;Murine herpesvirus 68;Mus;nanoparticle;neutralizing antibody;novel;novel vaccines;older men;Play;Population;Preventive;primary effusion lymphoma;Process;Production;Protein Subunits;Proteins;recombinant virus;Recombinants;Research;Resources;RNA vaccine;Role;Safety;self assembly;Side;Subunit Vaccines;Technology;Testing;tool;Transplant Recipients;Untranslated Regions;Vaccinated;Vaccine Antigen;vaccine candidate;Vaccine Design;vaccine development;vaccine efficacy;vaccine platform;Vaccines;Variant;vector vaccine;vector-based vaccine;Viral;Viral Pathogenesis;Viral Vector;Virus;Virus Diseases;Virus Replication;virus testing;Vulnerable Populations

PROJECT_TITLE: Development of three KSHV vaccine platforms and chimeric MHV68-K-G for in vivo mouse infection study

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (M2)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Due to the inablity of central nervous system to regenerate after injury, the vision loss in optic neuropathies such as glaucoma is irreversible and will eventually lead to permanent blindness. Based on the previous and preliminary data of an in vivo CRISPR forward genetic screen, this proposed study will address the scientific question why and how the regenerative fates of RGCs are pre-determined from an epigenomic perspective. By exploring the injured induced chromatin accessibility and gene expression profile changes in RGCs, the proposed study will ultimately provide novel drug targets for retinal regenerative medicine.

PI_NAMEs: TIAN, FENG  (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Affect;ATAC-seq;Award;axon regeneration;Blindness;Boston;Brain;career development;CCCTC-binding factor;Cell Death;cell regeneration;Cell Survival;Central Nervous System;Chromatin;chromatin remodeling;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Data;Epigenetic Process;epigenetic regulation;epigenomic profiling;epigenomics;experimental study;Eye;Gene Expression Profile;Genetic Screening;Glaucoma;Goals;in vivo;injured;Injury;insight;K-Series Research Career Programs;knock-down;Manuscripts;Mediating;medical schools;Mentors;Modeling;mouse model;Natural regeneration;Nerve Crush;Neurobiology;neurodevelopment;Neurons;new therapeutic target;novel therapeutics;Ophthalmology;Optic Nerve;optic nerve disorder;Outcome;Pediatric Hospitals;Persons;Phase;Positioning Attribute;Postdoctoral Fellow;Principal Investigator;Publishing;recruit;regenerative;regenerative biology;Regenerative Medicine;regenerative therapy;Research;research and development;Retina;Retinal Diseases;retinal ganglion cell degeneration;Retinal Ganglion Cells;Science;stem cell biology;Technology;Training Activity;translational study;United States;Universities;Work

PROJECT_TITLE: Epigenomic mechanisms regulating RGC survival and axon regeneration

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE HIV rates have been rising in China in the past decade and disproportionately affect transgender women, a population largely impacted by multi-levels of gender minority stress (i.e., stigma), which is detrimental to their mental and HIV-related behavioral health. The proposed research project will develop and test a gender- affirmative, stigma-reduction focused mobile health program that aim to address gender minority stress, promote mental and sexual wellness, and engage transgender women in HIV testing and other prevention services. This research will enhance research capacity for further HIV prevention and transgender health research in China.

PI_NAMEs: LIN, DANHUA ;OPERARIO, DON ;SUN, SHUFANG  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Advocacy;Affect;AIDS prevention;Anxiety;Area;Awareness;Behavior;behavior test;behavioral health;care systems;career;Cellular Phone;China;Chinese;cis-male;cisgender;Clinical;Clinical Trials;combat;Communities;community partners;Community Services;community-centered;coping;Coping Skills;cost;Counseling;Country;Coupled;Data;Development;Diagnostic Reagent Kits;Disclosure;Discrimination;efficacy study;efficacy trial;Eligibility Determination;empowerment;Epidemic;evidence base;experience;Face;Five-Year Plans;Fright;Future;Gender;gender affirmation;gender affirming intervention;Gender Identity;gender minority group;gender minority stress;Government;Grant;Health;health disparity;Health Professional;Health Promotion;Health Services;high risk;High Risk Woman;HIV;HIV Infections;HIV risk;Hospitals;Human immunodeficiency virus test;implementation study;improved;Individual;innovation;Institution;Intervention;Interview;Investments;Laws;Legal;Lesbian Gay Bisexual Transgender Queer;Longitudinal Studies;low and middle-income countries;Mediating;Medical;men who have sex with men;Mental Depression;Mental Health;mHealth;mhealth interventions;minority stress;mobile application;Modeling;neglect;Participant;peer;Persons;Phase;Pilot Projects;Population;pre-exposure prophylaxis;preference;Preparation;Prevalence;prevention service;Prevention strategy;primary outcome;Privacy;Procedures;Professional counselor;programs;Protocols documentation;Psyche structure;psychological distress;Public Health;Randomized, Controlled Trials;Recommendation;recruit;Research;Research Design;Research Personnel;Research Project Grants;resilience;Resources;response;Risk;Risk Factors;Role;Safety;satisfaction;secondary outcome;self testing;Series;service providers;Services;sex;Sexual and Gender Minorities;Sexual Health;sexual risk behavior;skills;skills training;social stigma;Stigmatization;stressor;Testing;therapy development;transfeminine;transgender;transgender women;transphobia;trend;Universities;Unsafe Sex;Victimization;Woman;Women's Health;Work

PROJECT_TITLE: Engaging Vulnerable Women in HIV Prevention and Health Promotion through a Stigma-Reduction Intervention: A Pilot Study

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biotechnology;Fentanyl Misuse and Addiction;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: PEARLAND

ORG_NAME: BASE PAIR BIOTECHNOLOGIES, INC.

ORG_STATE: TX

PHR: Project Narrative This proposal addresses the rapidly expanding need to detect small molecule drugs, including opiates and designer/illicit synthetics, therapeutic agents, potential WMDs like sarin, and toxic pesticides in the near-patient, home or field setting. Here we expand upon our prior development efforts and seek to commercialize a rapid, easy to use, near-patient/field-compatible interferometric testing system that is highly sensitive (pg/mL-ng/mL) and is compatible with many matrices.

PI_NAMEs: JACKSON, GEORGE W (contact)

PROGRAM_OFFICER_NAME: ASHMONT, KARI RICH

PROJECT_TERMS: Acids;Address;aptamer;Biological Assay;Blood;Blood capillaries;Buffers;Calibration;Cessation of life;Chemicals;Chemistry;commercialization;Compensation;Computer software;design;Detection;detection platform;Development;drug sensitivity;drug standard;drug testing;economic impact;Ensure;Environment;Environmental Pollutants;Epidemic;experience;Family;Fentanyl;Fingers;Generations;glyphosate;Gold;heroin use;Home;Hydrocodone;Immobilization;improved;instrument;Label;Laboratory Research;large scale production;Lasers;lateral flow assay;Legal patent;Letters;liquid chromatography mass spectrometry;Manufacturer;Marketing;Marriage;Methadone;Methodology;Methods;minimally invasive;Morphine;nanolitre;Narcotics;nerve agent;Norepinephrine;Norfentanyl;novel;Opioid;Optics;Overdose;Oxycodone;Patients;Peer Review;Pesticides;Pharmaceutical Preparations;Phase;Physicians' Offices;Preparation;prescription opioid abuse;Production;prototype;Publications;Pump;rapid test;rapid testing;Reader;Reproducibility;Rural Hospitals;Sampling;Sarin;Serum;small molecule;Specificity;Surface;Surface Tension;System;Technology;Technology Transfer;Tenofovir;Testing;Therapeutic;Therapeutic Agents;tool;Toxic Environmental Substances;Training;Translations;Ultraviolet Rays;United States;Update;Urine;user-friendly;Vendor;VX nerve gas;Walking;Work

PROJECT_TITLE: Bench-top Reader and Aptamer-based Assay for Rapid, High-sensitivity Drug/Opiate Detection


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: GREENVILLE

ORG_NAME: EAST CAROLINA UNIVERSITY

PHR: NARRATIVE: Prioritizing diversity in polygenic risk prediction of primary open-angle glaucoma Primary open-angle glaucoma (POAG) disproportionately affects individuals with global African ancestry, but genetic studies of POAG have predominantly focused on mainly European-descent individuals. The proposed research aims to better understand POAG genetics in African and African-descent individuals and develop genetics-based prediction tools to improve screening for POAG across different ancestries. In the long-term, this information could be used to identify patients at high risk for POAG who should be monitored for disease progression and might benefit from preventative treatments.

PI_NAMEs: COOKE BAILEY, JESSICA N (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: admixture mapping;Affect;Africa;African;African American population;African ancestry;Age;American;Area;aspirate;Biological;Blindness;burden of illness;case control;Classification;Clinical;clinical application;clinically relevant;Complex;Data;Data Set;Databases;Development;Disease;Disease Progression;Disparity;diverse data;Early Diagnosis;European;Evaluation;Future;gene discovery;Gene Frequency;Genes;Genetic;genetic architecture;Genetic study;genome wide association study;Genomic Segment;Ghana;Glaucoma;Health;Heritability;high risk;high risk population;improved;Individual;Intervention;Linkage Disequilibrium;Maps;Mediator;Meta-Analysis;Monitor;novel;Outcome;Pathway Analysis;Pathway interactions;Patients;Performance;Persons;Phenotype;polygenic risk score;Population;Population Heterogeneity;precision medicine;predictive tools;Predictive Value;preservation;Prevalence;Preventive care;Preventive treatment;Primary Open Angle Glaucoma;Publishing;Quality of life;Race;Research;Risk;Risk Factors;risk prediction;risk variant;Role;Sampling;screening;Secure;segregation;Signal Transduction;Site;Testing;Universities;Variant;Vision

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-P(02)M]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Cardiovascular;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Endometriosis;Estrogen;Heart Disease;Pain Research;Prevention;Women's Health Research

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Endometriosis is a debilitating estrogen-dependent gynecological disorder associated with chronic pelvic pain and a myriad of comorbidities associated with systemic inflammation including elevated cardiovascular disease (CVD) risk. We take an integrative physiology approach to examine the role of estrogens and LOX-1 receptor mechanisms mediating the increased CVD risk through parallel inflammatory mechanisms, and to examine two emerging interventions that have shown efficacy for reducing symptoms and long-term CVD risk in women with endometriosis. These studies have the potential to identify clinically relevant therapeutic targets and interventions to decrease CVD burden in women with endometriosis.

PI_NAMEs: ALEXANDER, LACY M. (contact);STACHENFELD, NINA

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Acceleration;Address;Affect;Age;Atherosclerosis;Biological Markers;Blood Vessels;brachial artery;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Physiology;Cardiovascular system;Caring;Cause of Death;Chronic;chronic pelvic pain;clinically relevant;comorbidity;Conjugated Estrogens;cytokine;density;Disease;effective intervention;effectiveness measure;endometriosis;Endometrium;endothelial dysfunction;Endothelium;epidemiologic data;Estradiol;Estrogen Receptors;Estrogens;experience;experimental study;GNRH1 gene;Goals;Gonadotropin Hormone Releasing Hormone;Gonadotropin Releasing Hormone Inhibitor;Gynecologic;Health;Human;Impairment;improved;in vivo;Infertility;Inflammation;Inflammation Mediators;Inflammatory;Intervention;Lectin;Lipoprotein Receptor;Low-Density Lipoproteins;LOX gene;Measures;Mediating;Metabolism;Modeling;Nature;Nitric Oxide;novel;Oral;Outcome;Oxidants;oxidized LDL receptors;oxidized lipid;Pain;Peripheral;Physicians;Physiological;Physiology;Pre-Clinical Model;Process;Production;Proliferating;receptor;Receptor Activation;reduce symptoms;reproductive;Reproductive Endocrinology;Research;Risk Factors;Role;salicylsalicylic acid;scavenger receptor;Scientist;Selective Estrogen Receptor Modulators;Series;Signal Transduction;Simvastatin;Site;standard care;Symptoms;Syndrome;systemic inflammatory response;Testing;Therapeutic Intervention;therapeutic target;Tissues;Uterine cavity;Vascular Diseases;Vasodilation;Woman;Women's mortality;Women's study

PROJECT_TITLE: Mechanisms and interventions addressing accelerated cardiovascular disease risk in women with endometriosis

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: RELEVANCE Recent studies reported increasing numbers of Plasmodium vivax infections in Duffy- negative individuals and that the parasites may have adapted to the African populations, but the erythrocyte invasion mechanisms are unknown. This study will investigate the expression and function of specific erythrocyte binding genes in Duffy-negative P. vivax and the immune response of Duffy-negative individuals to P. vivax infections in Ethiopia, where malaria is a major public health problem and about 30% of the 1.2 million confirmed malaria cases are P. vivax. Knowledge of P. vivax invasion mechanisms and host immune responses in Duffy negatives will have important implications for P. vivax vaccine development and vivax malaria risk assessment both within and outside Africa.

PI_NAMEs: LO, EUGENIA  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Africa;African;African ancestry;Age;Antibodies;Antibody Response;antigen binding;Antigens;Binding;Binding Proteins;Biochemical;Biological Assay;Candidate Disease Gene;candidate identification;Case Study;Cells;Classification;comparative;Copy Number Polymorphism;Data;density;Diagnosis;differential expression;Disease;DNA biosynthesis;Enrollment;Epidemic;Erythrocytes;Ethiopia;feasibility research;Flow Cytometry;Foundations;Gender;Gene Dosage;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;genomic signature;Genotype;Health;Immune response;Immunize;Immunoassay;Immunoglobulin G;In Vitro;in vivo;Individual;Infection;inhibiting antibody;Invaded;Knowledge;Ligand Binding;Ligands;Logistics;Malaria;Measures;Molecular;Mutation;Oryctolagus cuniculus;Outcome;parasite invasion;Parasites;Patients;Phenotype;Plasma;Plasmids;Plasmodium vivax;Plasmodium vivax vaccine;Population;Process;Proteins;Public Health;receptor;Recombinant Proteins;Reporting;Research;residence;Reticulocytes;Risk Assessment;RNA;sample collection;Sampling;Site;Surface;Time;transcriptome;transcriptome sequencing;Transfection;vaccine development;Variant;vector;Vivax Malaria;Whole Blood

PROJECT_TITLE: Plasmodium vivax Erythrocyte Invasion Mechanisms and Humoral Immune Response in Duffy Negative Africans

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Assistive Technology;Autoimmune Disease;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Kidney Disease;Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Hypoglycemia is a highly prevalent complication associated with frequent hospitalizations, worse survival, and psychological distress in end-stage kidney disease (ESKD) patients with diabetes mellitus (DM), underscoring the need for practical and reliable methods for glycemic assessment in this population. While traditional glycemic metrics have limitations in their accuracy, convenience, and accessibility, continuous glucose monitoring (CGM) provides automated, less invasive glucose measurements and more comprehensive glycemic data than conventional measures. This proposal will investigate whether use of CGM 1) enhances glycemic control, 2) reduces hypoglycemia risk, and 3) improves quality of life, diabetes distress, and fear of hypoglycemia in hemodialysis patients with DM.

PI_NAMEs: KALANTAR-ZADEH, KAMYAR ;RHEE, CONNIE MEEYOUNG (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: 2 arm randomized control trial;Accounting;Address;Adult;Affect;Agreement;Anxiety;Arrhythmia;Blood;Blood Glucose;Blood Glucose Self-Monitoring;cardiovascular health;Cardiovascular system;Cessation of life;Chronic Kidney Failure;Clinical Trials;cohort;Coin;comorbidity;Complication;Continuous Glucose Monitor;Data;Devices;diabetes distress;diabetes management;Diabetes Mellitus;diabetic;Diabetic Nephropathy;Dialysis patients;Dialysis procedure;Dialysis Solutions;End stage renal failure;Endocrine System Diseases;experience;Exposure to;Feasibility Studies;Food Access;Frequencies;Fright;Fructosamine;Future;Gluconeogenesis;Glucose;glycemic control;Glycemic Index;Glycosylated hemoglobin A;glycosylated serum albumin;Health Expenditures;health related quality of life;Hemodialysis;high risk;Hospitalization;Hyperglycemia;Hypoglycemia;Impairment;improved;indexing;Insulin Resistance;insulin secretion;Intervention;Kidney;Knowledge;Lead;Measurable;Measurement;Measures;Metabolism;Methods;Monitor;monitoring device;mortality risk;Myocardial Ischemia;non-diabetic;novel;Participant;Pathway interactions;Patient Outcomes Assessments;Patients;Peritoneal Dialysis;Pharmaceutical Preparations;Pilot Projects;Population;primary endpoint;psychological distress;Publishing;Quality of life;Randomized, Controlled Trials;Research;Risk;Safety;secondary endpoint;Site;Stress;study population;success;Surveys;Technology;Time;tool;Training;treatment as usual;trial comparing;Veterans;Well in self

PROJECT_TITLE: Continuous Glucose Monitoring in Dialysis Patients to Overcome Dysglycemia (CONDOR) Trial

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Dentin matrix metalloproteinases (MMPs) are considered key proteases for tissue breakdown that advance caries lesions, but the actual contribution of MMPs to disease progression and how their expression and activity are modulated are unclear. The K08 parent award will fill major gaps in understanding endogenous processes in caries progression and provide insights into interactions between the microbiome present at different stages of the disease with host responses that express and/or activate dentinal enzymes. This supplemental award aims to ensure the continuity of the proposed training and research goals, mainly related to dentin-pulp genomics and proteomics, OMICS approaches and techniques, bioinformatics, and scientific writing.

PI_NAMEs: DE MATTOS PIMENTA VIDAL, CRISTINA  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TITLE: Modulation of MMPs gene expression and activity by the microbiome in caries

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

PHR: PHS Relevance Statement. The determination of three-dimensional protein structures is essential for revealing molecular mechanism of disease processes, and also for structure-based drug design. Concomitantly, technological advances in protein design could revolutionize therapeutic treatment. With these advances, proteins and other molecules can be designed to act on today’s undruggable proteins or tomorrow’s drug-resistant diseases. The proposed computational and experimental studies of protein structures, dynamics, and design methodology will illuminate targets of biochemical and pharmacological significance, and the design of new therapeutics can alleviate mortality, morbidity, and human suffering.

PI_NAMEs: DONALD, BRUCE R. (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: 3-Dimensional;Algorithm Design;Algorithms;Antibodies;Antigens;Area;Binding;Biochemical;Biological;biophysical properties;Combinatorial Optimization;Computational Geometry;Computer Models;Computer software;computer studies;Computing Methodologies;data modeling;design;Disease;Disease Resistance;drug candidate;Drug Design;Drug resistance;Drug Targeting;experimental study;Future;Generations;Goals;Human;improved;In Vitro;in vivo;inhibitor;Investigation;Machine Learning;Measurement;Measures;Methodology;Methods;Modeling;Molecular;Molecular Biology;Morbidity - disease rate;mortality;Mutation;neutralizing antibody;new therapeutic target;novel;novel therapeutics;open source;pharmacologic;Probability;Process;Program Sustainability;Protein Dynamics;Protein Engineering;protein protein interaction;protein structure;Proteins;Research;Research Project Grants;resilience;Resistance;resistance mutation;response;Structure;System;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;Viral Antibodies

PROJECT_TITLE: Computational and Experimental Studies of Protein Structure and Design

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: NARRATIVE Individuals working as domestic cleaners, particularly in South Texas, are overwhelmingly Hispanic or Latina women and subject to numerous environmental and occupational hazards, including exposure to potentially toxic chemicals in cleaning agents and ambient exposures to VOCs in their residential environment. To our knowledge, there have been no studies exploring the burden of total volatile organic compound (VOC) exposure, nor potential health outcomes, experienced by this vulnerable population, who may experience `double jeopardy' through exposures both at work and at home. We will build on an existing academic-community partnership to recruit 100 Hispanic women working as domestic cleaners in San Antonio TX and, using a community-engaged approach, assess these women's total personal air exposure to VOCs, characterize determinants of exposure, and explore associations between total personal air VOC exposure and biomarkers of inflammation and oxidative stress.

PI_NAMEs: GIMENO RUIZ DE PORRAS, DAVID  (contact);HAN, INKYU ;WHITWORTH, KRISTINA WALKER

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Air;Air Pollution;airway inflammation;Asthma;Biological Markers;Blood;Chemicals;Classification;community academic partnership;community engaged approach;Country;Data;Development;early detection biomarkers;Education and Outreach;Educational Activities;Environment;Environmental Hazards;Environmental Health;environmental justice;Exclusion;Exhalation;experience;Exposure to;Future;Goals;Hazardous Chemicals;Health;health disparity;High Risk Woman;Hispanic;Hispanic Populations;Hispanic Women;Home;Home environment;Hour;Housekeeping;Immune;Immune response;Individual;Industrialization;Inequality;Inflammation;Inflammatory Response;irritation;Knowledge;Latina;Laws;Link;Lower respiratory tract structure;Measures;Minority;Modeling;Neighborhoods;Not Hispanic or Latino;Occupational;Occupational Exposure;occupational hazard;Occupational Health;Outcome;Oxidative Stress;Paint;Pathway interactions;Pattern;Persons;Physical condensation;Poison;Pollution;Positioning Attribute;Prevention;Prevention strategy;professional atmosphere;recruit;Reporting;Research;research study;residence;respiratory;respiratory health;Respiratory Signs and Symptoms;Risk;Sampling;self reported behavior;Solvents;Source;South Texas;successful intervention;systemic inflammatory response;Texas;Time;United States;Urine;volatile organic compound;Vulnerable Populations;Wages;Wheezing;willingness;Woman;Work;Working Women

PROJECT_TITLE: Study of Cleaners in San Antonio: Immunologic and Inflammatory Responses to Total Volatile Organic Compound (VOC) Exposure

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Clinical Research;Hematology;Lung;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: Project Narrative. Sickle cell disease (SCD) is the most common hemolytic disorder affecting African Americans. Acute pulmonary thrombosis is the underlying cause in ~20% of SCD patients hospitalized with respiratory failure; however, there is no available treatment to prevent pulmonary thrombosis in SCD. We propose to identify molecular and genetic mechanisms that trigger pulmonary thrombosis in SCD, which would enable the development of Precision Medicine for these sub-set of high-risk SCD patients.

PI_NAMEs: SUNDD, PRITHU  (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: Acute;Address;Adenosine Diphosphate;Adenosine Monophosphate;Affect;African American;African American population;antagonist;arteriole;Attenuated;Autopsy;Biochemical;Blood;Blood flow;Blood Platelets;Blood specimen;Clinical Trials;Development;Diagnostic;Disease;ecto-nucleotidase;Endothelium;Erythrocytes;Event;extracellular vesicles;Generations;Genes;Genetic;genetic analysis;genome analysis;Hemolysis;high risk;Hospitalization;Human;Image;Impairment;In Situ;In Vitro;in vivo;in vivo imaging;Inflammation;insight;Intravenous;intravenous administration;Introns;Lung;lung imaging;Microfluidics;Molecular;mouse model;multiphoton microscopy;Mus;novel;Pathway interactions;Patients;Plasma;Platelet Activation;Platelet aggregation;Platelet Aggregation Induction;precision medicine;prevent;Preventive therapy;receptor;Recording of previous events;Respiratory Failure;Risk;Secondary to;Sickle Cell Anemia;Signal Transduction;Single Nucleotide Polymorphism;Solid;Sterility;Testing;Therapeutic;Thrombocytopenia;Thrombosis;Thrombus;Time;whole genome;X-Ray Computed Tomography

PROJECT_TITLE: CD39-carrying extracellular vesicles regulate pulmonary thrombosis in Sickle Cell Disease

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative: HIV is a significant public health issue, and intersectional stigma (stigma from multiple dimensions, such as having mental health problems, gender, and/or sexual orientation) is an important barrier to achieving the 95- 95-95 goal, which is to diagnose 95% of all people living with HIV, provide antiretroviral therapy (ART) for 95% of those diagnosed, and achieve viral suppression for 95% of those receiving ART. To address this issue, we are proposing to develop a digital tool, called INterseCtional stigma assessment and reduction at multiple Levels and mUltiple DimEnsions (INCLUDE), for routine use in ART centers. The aim of this study is to assess the acceptability and feasibility of using INCLUDE to measure and address intersectional stigma and if successful, this can provide a valuable intervention for studying and addressing intersectional stigma.

PI_NAMEs: ACHARYA, BIBHAV  (contact);SAPKOTA, SABITRI

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;antiretroviral therapy;arm;Asia;care outcomes;Caring;Castes;Client;Clinic;Clinic Visits;Clinical;clinical care;Clinical Data;clinical practice;Clinical Trials;Cluster randomized trial;Consultations;dashboard;Data;design;Diagnosis;digital data;digital health;digital intervention;digital tool;Dimensions;Ensure;evidence base;Exclusion;experience;Face;Focus Groups;follow-up;Gender;Goals;Health Personnel;HIV;Human;human centered design;improved;Intervention;Intervention Studies;Interview;Lead;Link;Local Government;marginalization;Measures;Mental Health;Methods;Nepal;Outcome;Persons;Pharmaceutical Preparations;pilot test;pilot trial;Process;Process Measure;Professional counselor;prototype;Public Health;Race;recruit;Registries;Reporting;repository;Research;Research Personnel;routine care;Sex Orientation;Site;social stigma;Stigmatization;Symptoms;Testing;Text;Thinking;tool;treatment adherence;Viral;Viral Load result

PROJECT_TITLE: Developing and testing a digital health tool for INterseCtional stigma assessment and reduction at multiple Levels and mUltiple DimEnsions (INCLUDE) to improve HIV care in ART centers in Nepal

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Columbus

ORG_DEPT: NEUROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE  In the skin layer, pain-sensing neurons and keratinocytes together detect and modulate painful stimuli, yet how their interaction is disrupted in neuropathic pain conditions is poorly understood. This proposal aims to characterize their interaction, regulatory mechanisms, and functional impact in disease by developing and using novel human models and simple in vivo animal models of chemotherapy-induced peripheral neuropathy. The proposed study will provide insights into how neurons interact with their substrates in the skin layer to maintain function in health and disease and point to new therapeutic strategies in treating intractable neuropathic pain.

PI_NAMEs: SHIN, GRACE JI-EUN (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Afferent Neurons;Animal Model;Biological Assay;Biology;Cancer Patient;career;Cell Surface Proteins;cell type;Cells;chemotherapy;chemotherapy induced neuropathy;Chemotherapy-induced peripheral neuropathy;Clinic;Clinical Trials;Coculture Techniques;cutaneous sensory nerve;Development;Disease;Drosophila genus;Engineered skin;Environment;Epidermis;extracellular;Extracellular Matrix;foot;Foundations;Functional disorder;Genetic;genetic approach;Goals;Hand;Health;Human;Human Engineering;human induced pluripotent stem cells;human model;improved;in vivo;induced pluripotent stem cell;induced pluripotent stem cell technology;innovation;insight;Integrins;interdisciplinary approach;Intervention;Investigation;keratinocyte;Knowledge;Label;Larva;Lead;Link;Maintenance;Mediating;Membrane;Membrane Proteins;Microscopy;Modeling;Molecular;Monitor;Nerve;Neurons;Neuropathy;Neurosciences;Nociception;Nociceptors;novel;novel strategies;novel therapeutic intervention;Paclitaxel;Pain;painful neuropathy;Pathologic;Pathology;Pathway interactions;Patients;Peripheral;Peripheral Nerves;Peripheral Nervous System Diseases;Persons;Phenotype;Physiology;preservation;Prevention strategy;protective effect;protein expression;protein function;Proteins;Proteomics;Protocols documentation;Quality of life;receptor recycling;Recycling;Research;Resolution;response;Role;Sensory;sensory neuropathy;Skin;species difference;stem cell biology;Stimulus;Substrate Interaction;superresolution microscopy;Surface;Symptoms;Testing;Therapeutic;tool;Toxic effect;trafficking;Training;transcriptomics;translational approach;treatment strategy;Work

PROJECT_TITLE: Sensory neuron-skin interaction in health and disease

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]