ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: BINGHAMTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Project Narrative Adolescents who begin alcohol use early in life and continue drinking at high levels during adolescence put themselves at risk for alcohol-related effects on brain and behavior. This project will investigate the contribution of the brain “social” neuropeptide oxytocin system to social anxiety induced by adolescent alcohol exposure and will determine mechanisms underlying the anti-anxiety effects of oxytocin system activation.

PI_NAMEs: VARLINSKAYA, ELENA I;WERNER, DAVID F (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Acute;Adolescence;Adolescent;adolescent alcohol exposure;Adult;Affect;Affective;Agonist;alcohol effect;alcohol exposure;alcohol risk;alcohol sensitivity;Animals;Anti-Anxiety Agents;Anxiety;ATAC-seq;Attenuated;Behavior;Behavioral;Brain;Brain region;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Data;Dendritic Spines;density;design;DNA Methylation;Dose;drinking;early adolescence;early alcohol use;emerging adulthood;Epigenetic Process;epigenetic regulation;Ethanol;ethanol-induced social facilitation;Female;Fluorescent in Situ Hybridization;FOS gene;gene network;Genes;Genome;Glutamate Receptor;Histones;Human;Hypothalamic structure;Impairment;improved;LacZ Genes;Lateral;Life;male;Mediating;Messenger RNA;Methylation;Molecular;Morphology;mRNA Expression;National Institute on Alcohol Abuse and Alcoholism;neural;neural patterning;Neurobiology;Neuroimmune;neuromechanism;Neurons;Neuropeptides;neuroregulation;OXT gene;Oxytocin;Oxytocin Receptor;Pathway interactions;Peptides;pharmacologic;Procedures;protein expression;Rattus;receptor expression;recruit;Regulation;Reporting;Role;sex;Sex Differences;social;social anxiety;social deficits;Social Facilitation;Social Functioning;Social Interaction;Stimulus;System;Testing;transcriptome sequencing;Transgenic Organisms;underage drinking;Vertebral column;Viral;Work

PROJECT_TITLE: 2/8 NADIA U01 Adolescent Alcohol Exposure: Neural Contributors to Sex- and Exposure Timing-Specific Anxiety


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Relapsed and refractory T-cell lymphomas (TCL) are associated with poor clinical outcomes. However, we have identified a multikinase inhibitor that is selective for multiple kinases that have important cell-autonomous and non-cell-autonomous roles in the T-cell lymphomas. Therefore, we will conduct an investigator-initiated, multicenter, phase II study with this agent in multiple cohorts of relapsed/refractory T-cell lymphomas.

PI_NAMEs: WILCOX, RYAN A (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: antagonist;Antigens;Area;Cells;chemotherapy;Clinical;clinical efficacy;Clinical Research;cohort;Conceptions;Cutaneous T-cell lymphoma;cytokine;Cytokine Receptors;Data;early phase clinical trial;efficacy evaluation;efficacy study;Family;FDA approved;gain of function mutation;Genetic;Genetically Engineered Mouse;Goals;Growth;Heterogeneity;high throughput screening;Impairment;inhibitor;Investigation;JAK2 gene;JAK3 gene;kinase inhibitor;Ligands;Lymphoma;Macrophage;Macrophage Colony-Stimulating Factor Receptor;Malignant - descriptor;Medical;Molecular;Mutate;Myeloproliferative disease;novel;Oral;Outcome;Pathogenesis;Pathogenicity;Patients;Peripheral;pharmacodynamic biomarker;pharmacologic;Phase;phase 2 study;Phase II Clinical Trials;Phosphotransferases;Play;preclinical study;predictive marker;Receptor Inhibition;Recurrence;Recurrent disease;Refractory;Refractory Disease;Relapse;Research Personnel;Resistance;resistance mechanism;response;Role;Signal Pathway;Signal Transduction;src-Family Kinases;T-Cell Lymphoma;T-Cell Receptor;T-Lymphocyte;targeted agent;targeted treatment;Therapeutic;therapeutic target;Tissue Survival;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;TYK2;Tyrosine Kinase Inhibitor

PROJECT_TITLE: Pacritinib in rel/refr T-cell lymphomas

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Neurosciences

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE The goal of this project is to address the urgent need for effective, scalable adult literacy interventions by integrating breakthroughs in two separate fields: 1) the brain network science of resilience to reading disorders and 2) high-definition non-invasive brain network stimulation. This study will first establish the efficacy of a novel, non-invasive stimulation protocol on reading behavior and brain metrics; then will determine how stimulation-induced effects interact with baseline reading comprehension ability; and lastly, will identify whether stimulation-induced effects are more clinically-beneficial than canonical behavioral interventions. Results may foundationally change how we treat low adult literacy, and have the potential for wider reaching impacts on non-invasive stimulation protocols for other clinical disorders.

PI_NAMEs: ABOUD, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Acceleration;Address;Adult;Area;Award;Behavior;behavior test;Behavior Therapy;Behavioral;behavioral outcome;Big Data;Brain;brain based;Brain imaging;brain pathway;brain research;career;Cephalic;Child;Clinical;clinically relevant;Code;cognitive control;college;Communication;Complex;cost;Coupling;Data Collection;Data Storage and Retrieval;design;Development;disability;Disease;Economic Burden;economic outcome;Education;Educational process of instructing;Electroencephalography;Environment;Equipment;Faculty;Fellowship;Financial Support;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Funding;Funding Opportunities;Goals;Growth;Health;imaging facilities;Individual;Individual Differences;Infrastructure;innovation;Institution;Intervention;Knowledge;Language;Link;literacy;Low Prevalence;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Mathematics;Measures;meetings;Memory;Mentors;Mentorship;Meta-Analysis;Methods;multimodal neuroimaging;neural;neuroimaging;Neurosciences;new technology;noninvasive brain stimulation;novel;Occupational;older adult;Outcome;Paper;Pattern;Positioning Attribute;post intervention;pre-doctoral;Prevalence;prevent;Process;programs;Protocols documentation;Psycholinguistics;Public Health;Publishing;Pythons;Randomized;Reader;Reading;reading comprehension;Reading Disorder;Research;resilience;resilience biomarker;response;Running;Science;Secure;Special Education;Standardization;statistics;stem;Structure;success;Supercomputing;support network;symposium;Symptoms;System;Testing;theories;Training;United States National Institutes of Health;Universities;Visit;welfare;Work

PROJECT_TITLE: Bridging the gap between brain network science and high-definition non-invasive brain stimulation to develop a scalable adult literacy intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cost Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PI_NAMEs: SCHMITTDIEL, JULIE A (contact)

PROJECT_TERMS: Address;Affect;Area;Beverages;California;Caring;Clinic;Clinical;clinical care;Collaborations;Communication;Communities;Community Health Planning;community partners;comparative effectiveness;Consultations;Consumption;Cost Effectiveness Analysis;Databases;Dedications;design;Development;Diabetes Mellitus;Diabetes prevention;Disparity;disparity reduction;Dreams;Economics;Education;Effectiveness;Engineering;Epidemiologist;Equity;ethnic disparity;Evaluation;experimental study;Faculty;Food;Food Access;food insecurity;Generations;Grant;Health;health economics;health equity;health equity promotion;Health Food;health inequalities;health information technology;Health Insurance;health literacy;Health Services;Health system;Healthcare;Healthcare Systems;high risk population;Housing;improved;Institution;Institutional Practice;Intervention;Journals;Libraries;Machine Learning;Methodology;Methods;Modeling;models and simulation;multidisciplinary;Natural experiment;Nature;Non-Insulin-Dependent Diabetes Mellitus;open source;Policies;Policy Making;Policy Research;population health;Prevention;Productivity;programs;Public Health;Publications;racial disparity;Research;Research Personnel;Resources;safety net;Science;service organization;Services;Shapes;social;social determinants;Social Work;socioeconomic disparity;Source Code;structural health determinants;System;systematic review;Testing;Translational Research;translational scientist;Translations;Transportation;Treatment outcome;tutorial review;United States Dept. of Health and Human Services;uptake;Vulnerable Populations;webinar;Writing

PROJECT_TITLE: DREAMS - National Research Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The mission of our LAUNCH Program is to provide research training to talented trainees who are poised to become the future leaders of scientific inquiry in nephrology, urology, and hematology. Our proposed LAUNCH Program will aim to train 22 trainees annually and prepare these pre- and post-doctoral individuals to become well-rounded scientists equipped with the skillsets they need to thrive in successful research careers.

PI_NAMEs: KU, ELAINE  (contact);SAKAMOTO, KATHLEEN M;STOLLER, MARSHALL

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Academia;Achievement;Address;Adult;Affect;Area;Attention;Basic Science;Benign;Biomedical Research;California;career;Childhood;Clinical;Clinical Research;Clinical Sciences;Cognitive;Collaborations;Community of Practice;Creativeness;critical period;Development;Discipline;Environment;expectation;Exposure to;Faculty;Fostering;Funding;Future;Goals;Hematological Disease;Hematology;Income;Individual;Industry;Infrastructure;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;interest;International;Investigation;Kidney;Kidney Diseases;Knowledge;Leadership;Learning;Mentors;Mentorship;Methodology;Mission;Modeling;Nephrology;next generation;Non-Malignant;novel;Outcome;Pathway interactions;peer;peer coaching;peer networks;Postdoctoral Fellow;pre-doctoral;programs;Provider;Records;recruit;Research;research faculty;Research Personnel;Research Training;Resources;Rewards;Role;San Francisco;Science;Scientific Inquiry;Scientist;Self Efficacy;skills;social;success;Surveys;Talents;Teacher Professional Development;theories;Time;TNFSF15 gene;Training;Training Programs;Translational Research;undergraduate student;Universities;urologic;Urologic Diseases;Urology;Vision

PROJECT_TITLE: Learners to LeAders in benign Urology, benign Nephrology, and non-Cancer Hematology


PI_NAMEs: HUANG, ALISON  (contact)

PROJECT_TERMS: Achievement;Address;Administrative Personnel;Adult;Area;Articulation;Basic Science;Benchmarking;Benign;Biometry;California;canine model;career development;Childhood;Clinical Research;Clinical Sciences;cohesion;Collaborations;Committee Members;Communication;design;Development;Discipline;Disease;Elements;Ensure;Epidemiology;epidemiology study;Equilibrium;Evaluation;experience;Family Felidae;Feedback;Fellowship Program;Functional disorder;Funding;Geographic Locations;Goals;Health;Hematology;Hemodialysis;Human;improved;Individual;Infrastructure;Institution;inter-institutional;Intervention Trial;Investigation;Kidney;Laboratories;Leadership;Logistics;Medicine;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methodology;Mission;Monitor;Multicenter Trials;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrolithiasis;Nephrology;Non-Malignant;outreach;Postdoctoral Fellow;pre-doctoral;Productivity;professor;Program Development;Program Evaluation;programs;Recording of previous events;recruit;Research;Research Personnel;Research Training;Resources;response;Rest;Science;Scientific Advances and Accomplishments;Scientist;Site;Strategic vision;Structure;success;Symptoms;Teacher Professional Development;Time;TNFSF15 gene;Training;Training Activity;Training Programs;Translational Research;United States National Institutes of Health;Universities;Urinary Calculi;Urinary Incontinence;Urinary tract;urologic;Urologic Diseases;Urology;Vertebral column;Veterinary Medicine;Veterinary Schools;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: ADAMS, ALYCE SOPHIA (contact)

PROJECT_TERMS: Advisory Committees;Award;career;career development;Career Mobility;Center for Translational Science Activities;Coffee;Communities;Diabetes Mellitus;Diabetes prevention;disparity reduction;Dreams;Ensure;Equity;experience;Faculty;Feasibility Studies;Feedback;Funding;Future;Goals;Grant;health care delivery;health equity;Hour;improved;innovation;K-Series Research Career Programs;Mentors;minority investigator;Peer Review;Pilot Projects;programs;Reduce health disparities;Reporting;Research;Research Personnel;response;Science;Series;Site;success;System;Translational Research;Underrepresented Minority;Universities;virtual;Work

PROJECT_TITLE: DREAMS - Pilot and Feasibility Program


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cost Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health

PROJECT_TERMS: Area;California;career development;Clinical;Clinical Research;Communication;Communities;community partners;comparative effectiveness;Complex;cost;Cost Effectiveness Analysis;Data;data integration;design;Development;Diabetes Mellitus;Diabetes prevention;Discipline;Disparity;Dreams;Education;Epidemic;Equity;ethnic minority;evidence base;experimental study;Faculty;Family;food insecurity;Fostering;Funding;Health;health care delivery;health communication;health economics;health equity;health inequalities;Health system;high risk;Individual;Infrastructure;innovation;Institution;Intervention;Intervention Studies;low socioeconomic status;Machine Learning;medication compliance;member;Mentorship;Methods;models and simulation;Natural experiment;Non-Insulin-Dependent Diabetes Mellitus;novel;Observational Study;older adult;Policies;Policy Making;Policy Research;Population Heterogeneity;Prevalence;programs;racial minority;Research;Research Design;Research Methodology;Research Personnel;Resources;response;Rural Population;San Francisco;Science;Scientist;service organization;Site;Social Environment;Social Policies;System;therapy design;Translating;Translational Research;Translations;Underrepresented Populations;United States Dept. of Health and Human Services;Universities;Vulnerable Populations

PROJECT_TITLE: DREAMS - Enrichment Program


NIH_SPENDING_CATS: Behavioral and Social Science;Hematology;Kidney Disease

PI_NAMEs: CHERTOW, GLENN MATTHEW (contact)

PROJECT_TERMS: Academia;Address;Adult;Area;Benign;Biomedical Research;Biotechnology;Businesses;California;career;Career Choice;career development;Career Mobility;career preparation;Cells;Childhood;Cognitive;Communication;Community of Practice;Coupled;Critical Thinking;Data;Development;Developmental Biology;Discipline;Doctor of Philosophy;Education;Educational workshop;Effectiveness;Elements;Engineering;Ensure;evidence base;expectation;experience;Exposure to;faculty research;Feedback;Fellowship Program;flexibility;Fostering;Funding;Genomics;Goals;Grant;Hematology;improved;Incentives;Individual;Industry;Infrastructure;innovation;Institution;inter-institutional;International;Intuition;Investigation;Joints;Kidney;Knowledge;knowledge base;Leadership;Medicine;Mentors;Mentorship;Methodology;mid-career faculty;Mission;Nephrology;Office of Administrative Management;online community;Outcome;Pathway interactions;Physiology;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;professor;Program Development;programs;Publishing;Recommendation;Records;Research;Research Methodology;Research Personnel;Research Training;Resources;Rewards;Scholars Program;Science;Scientist;Secure;Self Efficacy;Self Management;Series;Side;Silicon;skills;social;Solvents;stem cell differentiation;Structure;Study Section;success;Supervision;Surveys;Talents;Technical Expertise;Technology;theories;tool;Training;Training Programs;Translational Research;Universities;Update;Urology;Work;Writing

PROJECT_TITLE: Professional Development Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Hematology;Kidney Disease;Pediatric

PI_NAMEs: TREADWELL, MARSHA J (contact)

PROJECT_TERMS: Active Learning;Adult;anti-racism;Area;Attention;Basic Science;Benign;Businesses;California;career;Childhood;Clinical;Clinical Research;Cognitive;Collaborations;Communication;Communities;community engagement;Community Outreach;Computer software;Data;Dedications;design;Discipline;Disease;Doctor of Philosophy;Education;effectiveness evaluation;Emotional;equity, diversity, and inclusion;evidence base;expectation;experience;Exposure to;Faculty;Feedback;Fostering;Foundational Skills;Funding Mechanisms;Future;Goals;Health Services Research;Hematology;high school;Individual;innovation;Institution;interest;International;Introversion;Investigation;Investments;Learning;Learning Skill;Medical Students;member;Mentors;Mentorship;mid-career faculty;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;next generation;Non-Malignant;Outcome;outreach;Pediatric Hematology;Pediatric Hospitals;peer;peer coaching;peer learning;peer networks;peer support;Personal Satisfaction;Process;Productivity;professor;programs;Psychologist;Research;Research Methodology;Research Personnel;Resources;response;satisfaction;Science;Scientist;Self Efficacy;Sickle Cell Anemia;skills;social;Social Network;Structure;success;symposium;System;teacher;theories;Time;TNFSF15 gene;tool;Training;Training Programs;Translational Research;undergraduate student;Underrepresented Populations;Universities;Urology;Vision;Visualization;Voice;Woman

PROJECT_TITLE: Network Core


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The vast majority of adults with obesity do not enroll in comprehensive evidence-based behavioral weight loss programs and as a result are less likely to achieve clinically meaningful weight loss. This study will test the effects of a brief, individually tailored intervention aiming to increase initiation of comprehensive behavioral weight loss treatment on weight. If the intervention is effective, it could be disseminated within primary care practices to increase the number of adults with obesity who achieve clinically meaningful weight loss.

PI_NAMEs: MCVAY, MEGAN APPERSON (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Address;Adoption;Adult;adult obesity;African American;Age;Appointment;arm;Behavior Therapy;Behavioral;Black race;Body mass index;Body Weight Changes;Body Weight decreased;Characteristics;Chronic Disease;Clinic;Clinical;Cluster randomized trial;cost;Counseling;Data;Demographic Factors;depressive symptoms;design;diabetes prevention program;Disparity;Distress;Education;effectiveness testing;Eligibility Determination;Enrollment;Ensure;Equity;Ethnic Origin;evidence base;Evidence based treatment;feasibility trial;Feedback;Frequencies;Gender;Goals;higher education;improved;Income;Individual;Insurance Carriers;Intervention;intervention effect;Interview;Low income;Maintenance;Mediator;men;Methods;Modeling;mortality;motivational enhancement therapy;novel;obese patients;Obesity;Obesity Epidemic;obesity treatment;Outcome;Participant;participant enrollment;Patients;Pattern;pilot trial;Population;population health;Population Heterogeneity;Primary Care;primary care clinic;primary care patient;primary care practice;primary care provider;primary outcome;Provider;Race;Randomized;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Risk;Sampling;Schedule;secondary outcome;Signal Transduction;Testing;tool;treatment center;two-arm study;United States Centers for Medicare and Medicaid Services;uptake;usability;Weight;weight loss intervention;weight loss program;Weight maintenance regimen;White Women;Work

PROJECT_TITLE: Increasing initiation of evidence-based weight loss treatment

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE The ECHO Pregnancy Cohort will improve the health of children for generations to come by identifying, in a diverse population, how environmental exposures involving pregnant individuals and their conceiving partners, before and during pregnancy, impact the health of their children from birth to the transition to adulthood. The ECHO Ohio Cohort Site will specialize in evaluating lifestyle exposures, in a diverse group of pregnant individuals and conceiving partners from preconception through the perinatal period, and their relationship to perinatal and child health outcomes. In addition to actively contributing to all areas of ECHO data collection and providing leadership for the program, we propose to focus on how cardiovascular health, including dysglycemia, during pregnancy are associated with an infant’s health at birth and a child’s neurodevelopment from birth to early adulthood.

PI_NAMEs: KEIM, SARAH ;LYNCH, COURTNEY DENNING-JOHNSON;SLAUGHTER, JONATHAN LEE (contact);VENKATESH, KARTIK KAILAS

PROGRAM_OFFICER_NAME: PARK, CHRISTINA H

PROJECT_TERMS: 21 year old;Adult;American Heart Association;Anthropometry;Appalachian Region;Area;Behavior;Birth;Black race;cardiovascular health;Child;Child Behavior;Child Health;Child health care;Childhood;Clinical;cohort;Collaborations;Communities;Conceptions;Continuous Glucose Monitor;Data;Data Collection;Data Element;Development;Dimensions;Disparate;emerging adult;Emotional;Enrollment;Ensure;Environmental Exposure;epidemiologic data;ethnic minority population;Ethnic Origin;experience;follow-up;Generations;Genes;Genetic;Genomic approach;Goals;Health;health data;Health system;high risk;Immigrant;Impairment;improved;Individual;Inequity;Infant Health;innovation;Investigation;Knowledge;Leadership;Life;Life Style;Long-Term Effects;Longitudinal Studies;Maternal and Child Health;Maternal Exposure;maternal risk;Measures;Mediating;Mediation;Mediator;Medical center;Methods;Molecular;Neonatal;neurodevelopment;Neurodevelopmental Impairment;Not Hispanic or Latino;offspring;Ohio;Outcome;Parents;Participant;Pathway interactions;Patients;Pattern;Pediatric Hospitals;Pennsylvania;Perinatal;perinatal period;Personal Satisfaction;Population;Population Heterogeneity;postnatal;Postpartum Period;Poverty;Pregnancy;Pregnancy Outcome;pregnant;prenatal;programs;Protocols documentation;public health relevance;racial minority population;recruit;Refugees;repository;Research;Research Personnel;Role;Rural;Secure;Site;social health determinants;suburb;Surveys;Techniques;Time;transition to adulthood;Underserved Population;United States National Institutes of Health;Universities;West Virginia;Work

PROJECT_TITLE: Environmental Influences on Child Health Outcomes (ECHO) and Pregnancy in Ohio

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The Patient Engagement Research Lab and J.C. Walter Jr. Transplant Center at Houston Methodist will partner with Saint Louis University, the Cooperman Barnabas Transplant Center, the National Kidney Foundation, and the Scientific Registry of Transplant Recipients’ Living Donor Collective initiative to improve living donor care and increase the number of potential living donors proceeding to actual donation. A team of scientists, ethicists, patient engagement and education specialists, clinicians, and living donors will conduct a multi-step study to identify clinical factors, social determinants of health, and other modifiable factors that contribute to evaluation discontinuation, especially for potential donors from underserved communities; develop and validate a living donor drop-out risk prediction index (LD-DROP) to identify which individuals would benefit from greater support; conduct community-engaged research to better understand how to support potential living donors at high-risk for drop-out; and pilot a positive donor experience intervention. This project will not only establish critical metrics and resources to better support and tailor the potential transplant donor experience, but also help decrease the kidney shortage by improving living donor support for everyone, particularly communities of color.

PI_NAMEs: WATERMAN, AMY DOGGETTE (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Address;Adult;Advocate;Black race;Caring;Chronic Kidney Failure;Clinical;Color;Communities;community engaged research;Confusion;Curiosities;Data Analyses;Databases;Decision Making;Development;Dialysis procedure;Disparity;disparity reduction;Donor person;Dropout;Drops;Early identification;Education;Educational Intervention;End stage renal failure;Ensure;Ethicists;ethnic minority;Ethnic Origin;Evaluation;experience;Face;Family member;Foundations;Fright;Gender;Geography;Goals;high risk;Hispanic;Hispanic Populations;improved;indexing;Individual;Institution;Intervention;Intervention Trial;Interview;Kidney;Kidney Failure;Latino Population;Living Donors;living kidney donor;Low income;low socioeconomic status;Medical;Methodist Church;Minority Groups;optimal treatments;Outcome;Patient Education;patient engagement;Patients;peer coaching;peer support;Persons;predictive tools;Preparation;prevent;Process;programs;prospective;psychosocial;Race;racial minority;Readiness;Research;Resources;Risk;Risk Factors;risk prediction;Scientist;screening;social health determinants;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Specialist;standard of care;Subgroup;Time;transplant centers;Transplant Recipients;transplant registry;Transplantation;underserved community;Underserved Population;Universities;Validation;volunteer;Vulnerable Populations;Work

PROJECT_TITLE: Transforming Curiosity into Donation: Validating a Risk Prediction Index to Detect and Prevent Drop-Out in Potential Living Kidney Donors who are Racial/Ethnic Minorities


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The primary goal of the Deep South KUH Premier Research and Inter-disciplinary Mentored Education (PRIME) program is to establish a fully integrated, interdisciplinary network of pre- and post-doctoral trainees in KUH research across the Deep South. We will do so by bringing together the unique research and training assets of Augusta University, Tulane University and the University of Alabama at Birmingham to create a unified KUH training ecosystem. The overall intent will be to better prepare translational scientists and clinician- scientists to become the future drivers of scientific breakthroughs in KUH research in our region and beyond.

PI_NAMEs: ASSIMOS, DEAN GEORGE;GUTIERREZ, ORLANDO M (contact);HOOVER, ROBERT S;KUTLAR, ABDULLAH

PROJECT_TERMS: Academy;Alabama;Area;Award;career;career development;career networking;Clinical;clinical center;Clinical Sciences;cohort;Collaborations;Communities;community building;Community Networks;Complex;Continuing Education;Country;Deep South;Development;Development Plans;Ecosystem;Education;educational atmosphere;Educational workshop;effective intervention;Entrepreneurship;Evaluation;Feedback;Fostering;Foundations;Funding Opportunities;Future;Goals;Grant;Health;health disparity;Hematological Disease;Hematology;improved;Individual;innovation;insight;Institution;interest;investigator training;Kidney;Leadership;Location;Manuscripts;Medicine;meetings;Mentors;Mentorship;Mission;Modernization;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Malignant;novel;novel strategies;Outcome;peer;peer coaching;Peer Review;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Prevention;Process;programs;recruit;Research;Research Personnel;Research Training;Science;Scientific Advances and Accomplishments;Scientist;Seminal;skill acquisition;skills;social media;success;TNFSF15 gene;Training;Training Activity;Training Programs;translational physician;Translational Research;translational scientist;United States;Universities;Urology;Vision;Voice;Writing


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Kidney Disease;Rural Health

PI_NAMEs: GUTIERREZ, ORLANDO M (contact)

PROJECT_TERMS: Alabama;Budgets;clinical center;Clinical Sciences;Collaborations;Communication;Communities;conflict resolution;Country;Data;Deep South;demographics;Development;disparity elimination;Ecosystem;Education;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;Event;flexibility;Focus Groups;Funding;Future;Grant;Health;health disparity;Hematological Disease;Hematology;Hybrids;Individual;Information Dissemination;insight;Institution;Intervention;Kidney;Leadership;Medicine;meetings;Mentors;Mission;Modernization;Monitor;Multimedia;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Malignant;organizational structure;Outcome;outreach;Performance;Persons;Prevention;Process;process improvement;Program Evaluation;programs;Progress Reports;recruit;Research;Research Personnel;Schedule;Schools;Science;Scientific Advances and Accomplishments;Scientist;Seminal;skills;Source;Structure;symposium;System;TNFSF15 gene;tool;Training;Training Programs;Translational Research;United States;United States National Institutes of Health;Universities;Urology;virtual;Vision;Work

PROJECT_TITLE: Deep South KUH Premier Research and Inter-disciplinary Mentored Education (PRIME)   Admin Core


NIH_SPENDING_CATS: Rural Health

PI_NAMEs: POLLOCK, JENNIFER S (contact)

PROJECT_TERMS: Alabama;career;Career Choice;career development;Clinical;cohort;collaborative environment;Communities;Deep South;Development;Dimensions;Discipline;Education;Educational workshop;Effectiveness;Ensure;Entrepreneurship;Environment;Equity;Extramural Activities;Faculty;Fostering;Foundations;Future;Goals;graduate student;Health;High School Student;improved;innovation;Institution;instructor;inter-institutional;Internships;investigator training;K-Series Research Career Programs;Leadership;Learning;matriculation;Medical Students;Medicine;member;Mentors;Mentorship;mid-career faculty;Mission;Modeling;Modernization;next generation;Nomenclature;Pathway interactions;peer;peer coaching;Peer Review;Postbaccalaureate;Postdoctoral Fellow;pre-doctoral;Productivity;Professional Education;professor;Program Development;programs;Research;Research Methodology;Research Personnel;Research Support;Research Training;Resources;role model;Science;Scientific Advances and Accomplishments;Scientist;skills;Students;Study Section;success;symposium;Time;TNFSF15 gene;Training;Training Programs;Training Support;undergraduate student;Universities;virtual;Vision;Writing

PROJECT_TITLE: Deep South KUH Premier Research and Inter-disciplinary Mentored Education (PRIME)  Professional Development Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  This project uses complementary psychophysical and electrophysiological approaches to evaluate the biological processes that underlie visually guided foraging behavior and will have two public health outcomes. First, it will inform the development of effective interventions for humans with diseases that impair navigation and object interaction while leaving visual processing intact. Second, it will suggest behavioral metrics and educational tools based on explicitly guiding visual attention for early detection of these disorders and to improve navigational decisions.

PI_NAMEs: SRINATH, RAMANUJAN  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: 3-Dimensional;3D virtual reality;Address;Affect;Alzheimer's Disease;Alzheimer's disease patient;Animals;Area;area V4;Attention;Behavior;Behavioral;Biological Process;Brain;Charge;Clinical;Code;Cognition;Cognitive;cognitive process;Complex;Cues;design;Development;Disease;Distant;Early Diagnosis;Education;effective intervention;Electrophysiology (science);entorhinal cortex;Environment;experience;experimental study;extrastriate visual cortex;Familiarity;flexibility;Food;Food Inspection;forest;frontal lobe;Fruit;Future;gaze;Goals;Health;Human;Impairment;improved;Investigation;Learning;Location;Measures;Mediating;Mentors;Modeling;Monkeys;neural;Neurons;novel;Novelty-Seeking Behaviors;object recognition;Outcome;Pattern;Population;Prefrontal Cortex;programs;Property;Psychophysics;Public Health;Published Comment;Research;response;Rewards;Role;Route;Scanning;Shapes;Short-Term Memory;Signal Transduction;skills;Source;Stimulus;Stroke;success;Techniques;Technology;Testing;theories;tool;Trees;virtual environment;virtual reality;virtual reality environment;Vision;Visual;Visual attention;Visual Cortex;visual information;Visual Perception;visual processing;Visual System

PROJECT_TITLE: Neural basis of flexible decisions in naturalistic environments


NIH_SPENDING_CATS: Rural Health;Social Determinants of Health

PI_NAMEs: HYNDMAN, KELLY  (contact)

PROJECT_TERMS: Advocacy;Advocate;Alabama;Area;Awareness;Biomedical Research;career;career development;career networking;cohort;Collaborations;Communities;community college;Deep South;Development;digital;disparity reduction;Education;Education and Outreach;Educational process of instructing;Educational workshop;Event;experience;Exposure to;Faculty;Fostering;Foundations;gender disparity;Goals;graduate student;Grant;Health;healthcare community;high school;Historically Black Colleges and Universities;Hour;Hybrids;Individual;innovation;Instagram;Institution;Interdisciplinary Study;interest;Journals;Lead;Learning;Marketing;Medicine;meetings;Mentors;Mission;Modernization;Newsletter;Occupations;outreach;peer;peer coaching;Peer Group;peer networks;Persons;podcast;Policies;Positioning Attribute;Postdoctoral Fellow;posters;programs;racial disparity;Relationship-Building;Research;Research Personnel;role model;Schedule;Schools;Science;Scientist;Seminal;Site;skill acquisition;skills;social;social media;Solid;Structure;Students;success;supportive environment;symposium;Time;TNFSF15 gene;Training;Training Programs;Twitter;Universities;virtual;Vision;Visit;Voice;web site;Woman;Work

PROJECT_TITLE: Deep South KUH Premier Research- Interdisciplinary Mentored Education (PRIME) Networking Core


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: FARMINGTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE Obstetric Life SupportTM (OBLSTM) is a validated simulation curriculum to train prehospital and hospital-based health care workers on preventing, recognizing, and managing maternal medical emergencies. This project will identify barriers and facilitators to implementation of OBLSTM in rural and low-resource settings, and adapt and test the intervention for these contexts. Findings will be used to promote national scale-up of this important health care innovation with the goal of improving patient safety and reducing inequities in maternal mortality and severe maternal morbidity.

PI_NAMEs: SHIELDS, ANDREA DENISE (contact)

PROGRAM_OFFICER_NAME: CHEW, EMILY

PROJECT_TITLE: Adaptation of an Evidence-Based Curriculum to Teach the Prevention, Evaluation and Treatment of Maternal Medical Emergencies for Pre-hospital & Hospital Healthcare Workers in Rural Context

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Dissemination and Implementation Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Rural Health

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE While studies confirm that rapid whole genome sequencing accelerates diagnoses and life-saving therapies in critically ill newborns, its adoption in clinical setting is lagging. We propose a dissemination and implementation science project to decrease healthcare inequities and improve adoption of genome sequencing in Level 4 (tertiary, metropolitan, higher resourced) and Level 3 (non-tertiary, rural, lower resourced) neonatal intensive care units.

PI_NAMEs: MALONE JENKINS, SABRINA  (contact)

PROGRAM_OFFICER_NAME: KULCHAK RAHM, ALANNA LEE

PROJECT_TERMS: Acceleration;Address;Adoption;career;career development;Characteristics;Clinical;clinical application;clinical care;clinical implementation;clinical trial implementation;cognitive task;Consensus;contextual factors;Critical Care;critically ill newborn;Data;design;Development Plans;Diagnosis;Dissemination and Implementation;dissemination science;education resources;effectiveness/implementation hybrid;empowerment;Ensure;evidence base;Evidence based intervention;experience;Family;Fostering;Funding;Future;genome sequencing;Genomic medicine;Genomics;Goals;Guidelines;Health;health care disparity;health care settings;Health Personnel;Human;implementation barriers;implementation research;implementation science;implementation strategy;improved;Infrastructure;innovation;Institution;Intervention;K-Series Research Career Programs;Knowledge;Life;Logic;Maintenance;member;Mentors;Methodology;metropolitan;Modeling;multidisciplinary;Neonatal;Neonatal Intensive Care Units;Outcome;Patients;Perception;personalized medicine;Physicians;Pilot Projects;Practical Robust Implementation and Sustainability Model;precision medicine;programs;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Personnel;Resources;Role;Rural;Scientist;skills;Specific qualifier value;Speed;standard of care;success;Surveys;task analysis;Techniques;Technology;Testing;Time;tool;Training;Training and Education;Translational Research;underserved area;uptake;usability;whole genome

PROJECT_TITLE: Addressing the research-practice gap in the implementation of rapid whole genome sequencing in the NICU

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project narrative It is imperative to train researchers in clinical, scientific and technological areas to advance the fields of Kidney, Urology and Hematology (KUH) towards bringing better understanding and management to KUH conditions and diseases. This program in North Carolina combines expertise and novel concepts in Training, Research, Innovation, and Outreach to form the NC KUH TRIO Program, bringing together six institutions across the state; 3 academic medical centers and 3 historically black universities that have strong science, technology, and engineering programs. TRIO will support pre- and post-doctoral trainees, providing them with innovative research tools and a professional development foundation to launch KUH research careers.

PI_NAMEs: ATALA, ANTHONY ;FALK, RONALD J (contact);ORTEL, THOMAS L

PROJECT_TERMS: Abbreviations;Academia;Academic Medical Centers;Acceleration;Address;Agriculture;Area;Artificial Intelligence;Biological Sciences;Biomedical Engineering;broadening participation research;career;career development;Caring;Clinical;Clinical and Translational Science Awards;clinical translation;cohort;college;commercialization;Degree program;Development;Discipline;Disease;Doctor of Philosophy;Engineering;Entrepreneurship;Epidemiology;equity, diversity, and inclusion;Evaluation;experience;Faculty;Fellowship;forging;Fostering;Foundations;Funding;Future;Genomics;Goals;Government;Grant;Growth;hands-on learning;Hematological Disease;Hematology;high school;Historically Black Colleges and Universities;Home;Immunology;improved;Individual;Industry;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;International;Kidney;Kidney Diseases;Lead;Learning;Link;Longevity;Manufactured basketball;Manufactured football;medical specialties;Mentors;Minority Groups;Minority-Serving Institution;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;North Carolina;novel;outreach;outreach program;Pathway interactions;Patient-Focused Outcomes;Patients;physical science;Physicians;Population;Postdoctoral Fellow;pre-doctoral;Principal Investigator;programs;Research;Research Personnel;Research Training;Resources;Science;Science, Technology, Engineering and Mathematics;skill acquisition;skills;STEM program;student retention;summer program;symposium;System;Talents;Technology;tissue regeneration;TNFSF15 gene;tool;Training;Training Programs;Underrepresented Minority;Universities;urologic;Urologic Diseases;Urology;virtual

PROJECT_TITLE: U2C/TL1 NC KUH TRIO Program


PI_NAMEs: FALK, RONALD J (contact)

PROJECT_TERMS: Agriculture;Cancer Education Grant Program;Clinical;Clinical and Translational Science Awards;Collaborations;Communication;Complement;cost;Counseling;Coupling;Data;design;Development;Disease;Ensure;Epidemiology;equity, diversity, and inclusion;Evaluation;evidence base;experience;Faculty;Fostering;Funding;Future;Goals;Health Services Research;Hematology;Historically Black Colleges and Universities;implementation science;improved;Infrastructure;innovation;Institution;Justice;Kidney;Leadership;learning network;Life;Link;manufacture;meetings;Mentors;Mind;Mission;North Carolina;outreach program;Patient Care;Persons;Process;Program Evaluation;programs;Research;research and development;Research Personnel;Resources;Role;Schedule;Science;skills;Speed;Structure;symposium;System;technology development;Textiles;TNFSF15 gene;Training;Translational Research;Travel;United States National Institutes of Health;Universities;Urology;virtual;Work

PROJECT_TITLE: TRIO Administrative Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE A major barrier to treatment for maternal opioid use disorder (OUD) is the buprenorphine induction process, which requires moderate withdrawal symptoms and is a critical timepoint of treatment dropout. A bridge induction method using a transdermal buprenorphine patch may be an efficacious method to minimize withdrawal symptoms and increase induction success. We propose a prospective, mixed-methods study at two OUD- specific prenatal clinics to evaluate the feasibility of conducting a randomized controlled trial comparing buprenorphine transdermal bridge induction versus standard sublingual induction in pregnant patients with OUD.

PI_NAMEs: KELLY, JEANNIE CHEN (contact)

PROGRAM_OFFICER_NAME: RAMEY, TANYA S

PROJECT_TERMS: Adherence;American College of Obstetricians and Gynecologists;arm;barrier to care;black patient;Black Populations;Buprenorphine;buprenorphine treatment;Case Series;Clinic;Clinical;comparative efficacy;Consensus;Data;design;Discipline of obstetrics;Dose;Dropout;Drops;efficacy evaluation;Eligibility Determination;Equity;Etiology;Exercise;experience;Face;Failure;Feasibility Studies;Feedback;Fetal Growth Retardation;follow-up;Goals;Health Personnel;high risk;Hospital Costs;Hour;implementation science;improved;improved outcome;Incidence;Individual;Infant;Intervention;intervention delivery;Interview;intraamniotic infection;Investigational Drugs;Maternal Mortality;maternal opioid use;Maternal-fetal medicine;member;Methods;Michigan;Morbidity - disease rate;mortality;mu opioid receptors;multi-site trial;Neonatal;Neonatal Abstinence Syndrome;neonatal outcome;New Drug Approvals;obstetric outcomes;obstetrical complication;Opioid;Opioid agonist;opioid misuse;opioid use;opioid use disorder;Outcome;Outpatients;overdose risk;Pain management;participant enrollment;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Phase;Population;Postpartum Hemorrhage;Pregnancy;pregnant;Pregnant Women;Premature Birth;prenatal;Prenatal care;Prevalence;Procedures;Process;prospective;Protocols documentation;Publishing;Race;racism;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Relapse;Reporting;Research;Research Activity;Research Methodology;retention rate;rural patients;Rural Population;Severities;Site;Specialist;Structure;success;Testing;Time;treatment adherence;Treatment Protocols;trial comparing;United States;Universities;Washington;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Using the Transdermal Patch for Buprenorphine Induction during Pregnancy: A Pilot Randomized Controlled Trial

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: ROY-CHAUDHURY, PRABIR  (contact)

PROJECT_TERMS: Address;Applications Grants;career;Career Choice;career development;Caring;Clinical;clinical practice;Collaborations;Communication;Communities;Community Health;Creativeness;Critical Thinking;curriculum development;design;Development;Development Plans;Discipline;Disease;Disparity;diversity and equity;Dose;Educational Curriculum;Ensure;Environment;Equity;equity, diversity, and inclusion;evidence base;Exposure to;Faculty;faculty mentor;Feedback;Fostering;Foundational Skills;Goals;Growth;hands-on learning;Health;health disparity;Health Professional;Healthcare;Hematology;improved;Individual;innovation;insight;Institution;Instruction;interest;Justice;Kidney;Knowledge;medical specialties;Mentors;Mentorship;multidisciplinary;North Carolina;Outcome;outreach program;Pathway interactions;patient population;Patients;peer;personalized learning;Professional counselor;Program Development;programs;recruit;Research;Research Personnel;Research Training;Resources;role model;satisfaction;Science;Scientist;senior faculty;skills;success;support network;symposium;Talents;teacher;technology research and development;Textiles;Thinking;Time;TNFSF15 gene;Training;Training Programs;Urology

PROJECT_TITLE: TRIO Professional Development Core


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Liver Disease;Nutrition

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Prescription and non-prescription medications, which include vitamins, herbal preparations, or, non-traditional forms of medicines, can very rarely cause significant liver injury. Because these events are so rare, the NIH has established a network of investigators to identify these rare causes of liver injury so that a shared database can be used for future studies. The USC-UCLA Drug-Induced Liver Injury Clinical Center desires to continue to work with this established network to better understand causes of liver injury due to these agents.

PI_NAMEs: STOLZ, ANDREW ABBA (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Acute;acute liver injury;Ancillary Study;Assessment tool;Cell Death;Cholestasis;clinical center;Clinical Treatment;Collection;County;Data Coordinating Center;Databases;Development;dietary supplements;drug induced liver injury;Endoplasmic Reticulum;Enrollment;ethnic diversity;Etiology;Event;follow-up;Future;hepatocellular injury;Herbal supplement;Immune;Immune checkpoint inhibitor;inhibitor;Knowledge;liver injury;Los Angeles;Mediating;medical schools;Medicine;Mitochondria;Natural Immunity;novel;patient population;Patients;Pharmaceutical Preparations;pharmacovigilance;phase 2 study;Pilot Projects;Plant Preparations;Population Heterogeneity;preservation;Proteins;Protocols documentation;research clinical testing;Research Personnel;Resources;response;Role;Scientific Advances and Accomplishments;shared database;Talents;treatment trial;Underrepresented Populations;United States;United States National Institutes of Health;Vitamins;Work

PROJECT_TITLE: USC-UCLA Drug-Induced Liver Injury (DILI) Clinical Center


PI_NAMEs: GIBSON, KEISHA L (contact)

PROJECT_TERMS: Agriculture;Biomedical Research;career;cohort;Collaborations;Communication;Communities;community building;Community Outreach;Creativeness;design;Development;Disease;Diverse Workforce;E-learning;Engineering;Environment;Event;experience;Fostering;Goals;Growth and Development function;hands on research;Historically Black Colleges and Universities;improved;Infrastructure;innovation;Institution;Leadership;Learning;lectures;Medical Research;meetings;Mentors;multidisciplinary;next generation;North Carolina;Outcome;outcome disparities;Pathway interactions;Patient-Focused Outcomes;peer;peer coaching;peer networks;Persons;Physicians;Process;programs;recruit;Research;Research Personnel;Resources;Rewards;skills;social;social media;Structure;symposium;System;Talents;tool;Training;Universities;virtual;workforce needs

PROJECT_TITLE: TRIO Networking Core


NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Dietary Supplements;Eye Disease and Disorders of Vision;Genetics;Human Genome;Nutrition;Pediatric;Prevention;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE Microphthalmia, anophthalmia and coloboma (MAC) are eye defects that can be caused by damaging sequence variants in the genes in the retinoic acid synthesis pathway and by vitamin A deficiency. In this proposal, we will examine patients with MAC, perform genome sequencing and measure vitamin A levels to examine the importance of genotypic and environmental factors relating to the retinoic acid pathway in the severity of MAC.

PI_NAMEs: SLAVOTINEK, ANNE M. (contact);TIBREWAL, SHAILJA

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Affect;All-Trans-Retinol;Animal Model;Anophthalmos;Asian ancestry;Bilateral;Blindness;Cataract;Child;Childhood;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coloboma;comorbidity;Congenital Abnormality;Country;Data;Defect;Development;Developmental Gene;Diagnosis;disease-causing mutation;Environmental Risk Factor;European ancestry;Eye;Eye Development;Frequencies;gain of function;gene environment interaction;Gene Expression;gene function;Genes;Genetic;genetic testing;genetic variant;Genetic Variation;genome analysis;genome sequencing;Genotype;Image;improved;Incidence;India;Individual;Larva;Measurement;Measures;Microphthalmos;Morphogenesis;Mothers;mouse model;Newborn Infant;Night Blindness;Optic Nerve;Pathogenesis;Pathogenicity;Pathway interactions;Patient Recruitments;Patients;Phenotype;Plasma;Population;Predisposition;Pregnancy;prevent;Prevention strategy;prospective;Public Health;Quality of life;Recording of previous events;Residual state;Retinal Detachment;Retinol Metabolism Pathway;screening;Severities;single-cell RNA sequencing;Supplementation;Symptoms;Testing;Therapeutic;therapeutic target;Time;Tissues;Titrations;transcription factor;Tretinoin;Umbilical Cord Blood;Variant;Vision;Visual;Visual impairment;Vitamin A;Vitamin A Deficiency;whole genome;Work;World Health Organization;Zebrafish

PROJECT_TITLE: Microphthalmia, anophthalmia and coloboma (MAC) and retinoic acid pathway genes

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Cystic Fibrosis;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Nanotechnology;Orphan Drug;Pneumonia;Pneumonia and Influenza;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: NARRATIVE  Pseudomonas aeruginosa (Pa) cause severe infections in patients with burns, severe wounds, pneumonia, or undergoing nosocomial procedures; however most Pa strains are resistant to many antibiotics limiting the treatment options. Vaccination is perhaps the greatest health advancement of our lifetime, and our vaccine to prevent Pa – regardless of initial injury or Pa strain – will positively impact all of us since as we age we all have a greater risk of a potential Pa infection. Our vaccine is aimed at preventing these infections as well.

PI_NAMEs: PICKING, WENDY L. (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Achievement;Acute;Acute Pneumonia;Adjuvant;Age;Antibiotic Resistance;Antibiotics;Antibodies;Antigen-Presenting Cells;Antigens;Bacteria;biophysical techniques;Burn injury;Catheterization;Cell membrane;Cells;clinically relevant;Critical Illness;cystic fibrosis patients;cytokine;Cytoplasm;Development;Distal;Dryness;Elderly;Emulsions;enterotoxigenic Escherichia coli;Exhibits;Explosion;Formulation;Goals;Health;human pathogen;IL17 gene;Immune response;Immunize;Infection;Infection prevention;Injury;Innate Immune System;Intubation;L Cells;Laboratories;Licensing;Lung;Manuscripts;Mediating;Microbial Biofilms;Molecular;Morbidity - disease rate;mortality;Mucous Membrane;Multi-Drug Resistance;multidrug-resistant Pseudomonas aeruginosa;Mus;mutant;nanoparticle;Natural Immunity;Nature;Needles;Nose;novel vaccines;Oils;Outcome;Particulate;pathogen;Pathogenesis;pathogenic bacteria;Patients;Pneumonia;Powder dose form;Preparation;prevent;Procedures;prophylactic;Proteins;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Public Health;Publishing;Pulmonary Challenge;Rattus;resistant strain;Risk;Risk Factors;Rodent;Suspensions;Syringes;Technology;Temperature;Time;Toxin;Type III Secretion System Pathway;uptake;Vaccinated;Vaccination;vaccine formulation;Vaccines;Water;wound

PROJECT_TITLE: An intranasal room stable vaccine formulation to prevent Pseudomonas aeruginosa  (R21AI169691)

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Disease;Prevention

PHR: Project Narrative Good drugs can sometimes hurt the liver, and it is not currently possible to identify which patients will develop this problem from a given drug. The Drug-Induced Liver Injury Network will continue to identify and enroll sufficient numbers of susceptible patients, and apply cutting-edge scientific methods to improve understanding of this problem, with the goal of improving the liver safety of new and existing drugs.

PI_NAMEs: WATKINS, PAUL B (contact)

PROJECT_TERMS: Acceleration;acute drug induced liver toxicity;Adopted;African American population;Ancillary Study;Area;Authorship;Biochemical;Biological;Biological Markers;Budesonide;Chemistry;Church;Clinical;clinical application;clinical center;Clinical Trials;cohort;Collaborations;Community Healthcare;Conduct Clinical Trials;Databases;dietary supplements;drug induced liver injury;Drug Prescriptions;Drug Utilization;Electronics;Enrollment;Etiology;European;Faculty;Feasibility Studies;Funding;Future;Genetic;Genetic Risk;Goals;guided inquiry;Herbal supplement;Histologic;Historically Black Colleges and Universities;improved;insight;instrument;Lead;Leadership;Link;Liver;liver injury;Mentors;metabolomics;Methods;minority patient;National Center for Advancing Translational Sciences;National Institute of Environmental Health Sciences;non-genetic;North Carolina;open label;Pathogenesis;Patients;Pharmaceutical Preparations;pharmacovigilance;Physicians;Pilot Projects;Positioning Attribute;post-market;Predisposition;Prevention;Publications;Records;recruit;Registries;Research;Research Personnel;Resources;Risk Management;Role;Safety;Severities;social media;Time;Toxicogenomics;Universities;web site;Whole Blood;Work

PROJECT_TITLE: University of North Carolina Clinical Center for DILIN


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Services;Lung;Pediatric;Prevention

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The goal of this prospective, randomized, double blind, controlled trial is to determine if the early initiation of bilevel positive airway pressure (BPAP) is effective and safe in pediatric patients presenting to a pediatric emergency department with acute moderate to severe asthma exacerbations who fail first line therapy. BPAP is a form of non-invasive positive pressure ventilation that may stent open airways, improve mucous clearance, recruit alveoli, and increase responsiveness to continuous beta-agonist therapy in the small distal airways. Given the large burden acute asthma exacerbations places upon the healthcare system, the results of the proposed study are of great public health importance.

PI_NAMEs: WILSON, PATRICK THOMAS (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: 17 year old;Accident and Emergency department;Acute;acute care;Admission activity;Adverse event;Aftercare;Agonist;Alveolar;Alveolus;aspirate;Asthma;asthma exacerbation;Blinded;Child;Child Mortality;Childhood;Childhood Asthma;Clinical;clinical practice;Clinical Trials;Consumption;Control Groups;cost;Critical Care;Data;Disease;Disease Marker;Distal;Double-Blind Method;Education;Forced expiratory volume function;Goals;Guidelines;Healthcare Systems;Hospitalization;Hour;Hypotension;improved;Inhalation;Intervention;Length;Managed Care;Measurement;Measures;Mechanical ventilation;Monitor;Mucous body substance;National Heart, Lung, and Blood Institute;Nebulizer;Obstruction;Outcome Measure;Oxygen;patient oriented;Patients;pediatric emergency;Pediatric Hospitals;Pediatric Intensive Care Units;pediatric patients;Physiological;Pneumothorax;positive airway pressure;pressure;prevent;Prevention program;primary outcome;Process;prospective;Public Health;Randomized;Recommendation;recruit;Resources;respiratory;Respiratory Failure;Respiratory physiology;Role;secondary outcome;Secondary to;Severity of illness;side effect;Skin;Stents;Tachycardia;Time;Time Management;Tremor;United States;United States National Institutes of Health;ventilation;Vomiting;Work of Breathing

PROJECT_TITLE: Understanding the role of bilevel positive airway pressure (BPAP) in pediatric acute asthma exacerbations: A prospective, randomized, double blind, controlled trial.

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: GREENSBORO

ORG_NAME: UNIVERSITY OF NORTH CAROLINA GREENSBORO

PHR: Project Narrative This project has important public health implications, due to its focus on parent and child well-being in the ongoing COVID-19 pandemic. Understanding how COVID impacts long-term parent and child well-being, as well as which parents and children are most negatively impacted by the pandemic and potential protective factors will provide essential information for future prevention and intervention programs.

PI_NAMEs: SATTLER, KIERRA MARIE PETTIT (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 4 year old;5 year old;Academic skills;Address;Adverse effects;Attention;Back;Behavioral;Birth;Buffers;caregiving;Child;Child Rearing;Child Welfare;cohort;COVID-19;COVID-19 impact;COVID-19 pandemic;current pandemic;Data;Development;Dimensions;Distress;early childhood;economic disparity;economic impact;Economics;emotional adjustment;Ethnic Origin;experience;Family;Family Relationship;family support;Future;future pandemic;Growth and Development function;Health;health disparity;Heterogeneity;high school degree;Hour;Household;Income;income disparities;indexing;infancy;Infant;Influentials;interest;intervention program;Interview;Interviewer;Investigation;Knowledge;Life;Link;long term consequences of COVID-19;longitudinal, prospective study;maltreatment;Measures;Mental Health;Mothers;National Institute of Child Health and Human Development;Nature;Neighborhoods;Outcome;pandemic disease;pandemic impact;pandemic stressor;parental influence;Parents;Personal Satisfaction;physical conditioning;Postpartum Period;Poverty;Pregnancy;prenatal;Prevention program;programs;protective factors;Public Health;Race;racial disparity;Recontacts;Reporting;Research;resilience;Resources;response;Risk;Risk Factors;SARS-CoV-2 negative;satisfaction;Schools;social;Social Interaction;Social support;Special Supplemental Nutrition Program for Women, Infants, and Children;Strategic Planning;stressor;System;Testing;Time;timeline;Underserved Population;Vulnerable Populations;Woman;Work

PROJECT_TITLE: The Impact of COVID-19 on Parent and Child Well-Being in Early Childhood

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Emergency Care;Emerging Infectious Diseases;Health Services;Hematology;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Palliative Care;Patient Safety;Precision Medicine;Rare Diseases;Sepsis

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE Each year, millions of patients with acute respiratory failure or sepsis present to U.S. emergency departments at high risk for death but without requirements for life support. Admission of these patients to intensive care units (ICUs) or hospital wards varies considerably with hospital capacity strain, and significantly impacts patient outcomes. Using detailed electronic health record data, instrumental variable and mediation analyses, and machine learning, we will identify the subgroups, care processes, and complications of care that account for these triage-related outcomes, thereby promoting personalized triage and better outcomes.

PI_NAMEs: ANESI, GEORGE L (contact);HALPERN, SCOTT D;LIU, VINCENT

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Accident and Emergency department;Accounting;Acute;acute care;Acute Renal Failure with Renal Papillary Necrosis;Acute Respiratory Distress Syndrome;Acute respiratory failure;Admission activity;Affect;Algorithms;American;Antibiotics;California;Caring;Cessation of life;Chronic Obstructive Pulmonary Disease;Classification;Clinical;cohort;Collaborations;Complex;Complication;Consultations;COVID-19;COVID-19 impact;COVID-19 pandemic;current pandemic;Data;Data Set;Delirium;Development;Diagnostic;Electronic Health Record;Elements;end of life care;experience;future pandemic;Goals;Guidelines;Health Care Costs;Health system;Heart failure;Heterogeneity;high risk;Hospitalization;Hospitals;Hour;Iatrogenesis;improved;improved outcome;indexing;Infection;innovation;Inpatients;insight;Intensive Care Units;Knowledge;Length of Stay;Life;Liquid substance;Location;Machine Learning;Measures;Mediation;Mediator;meetings;Methodology;Methods;Modeling;mortality;mortality risk;multidisciplinary;novel;Outcome;Palliative Care;pandemic disease;Patient Admission;Patient Care;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Pennsylvania;Phenotype;Population Heterogeneity;preservation;Probability;Process;Public Health;Recommendation;Resistance;Sepsis;septic patients;Steroids;Subgroup;Syndrome;Testing;treatment pattern;Triage;Universities;unsupervised learning;Update;Urinary tract infection;ward;Work

PROJECT_TITLE: Identifying patient subgroups and processes of care that cause outcome differences following ICU vs. ward triage among patients with acute respiratory failure and sepsis

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Genetics

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative Telomere maintenance by telomerase is critical for genome integrity, regulation of cellular lifespan, and tumor suppression. Here we focus on the cell biology of telomerase and investigate the timing, dynamics, and spatial coordination of telomere extension in the crowded nucleus of cancer cells. Our study will have profound implications for the development of strategies to block telomere maintenance and design better cancer therapies.

PI_NAMEs: CHARTRAND, PASCAL ;SFEIR, AGNEL  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Aging;Bacteriophages;Base Pairing;Biochemical;Biology;cancer cell;cancer therapy;Catalytic Domain;Cell Aging;cell fixing;cell growth regulation;Cell Nucleus;Cell Proliferation;Cells;Cellular biology;Chromosomal Stability;Chromosomes;Crowding;Cytoplasmic Granules;Data;design;Development;DNA;Engineering;Ensure;Enzymes;Eukaryotic Cell;experimental study;fluorophore;Future;Genetic;genetic approach;genome integrity;Goals;Human;Image;image visualization;imaging modality;innovation;Label;Length;life span;Ligation;Light;Link;Maintenance;Malignant Neoplasms;Mechanics;Membrane;Methodology;molecular imaging;MS2 coat protein;novel;Organelles;Phase;photoactivation;Photobleaching;Physiological;prevent;Prevention;Process;Proteome;Proteomics;recruit;Regulation;Ribonucleoproteins;RNA;RNA-Directed DNA Polymerase;Role;single molecule;stem;superresolution imaging;System;TEL1 Gene;Telomerase;Telomerase RNA Component;telomere;Telomere Maintenance;Testing;trafficking;Tumor Suppression;Untranslated RNA;Visualization;Work;Yeasts

PROJECT_TITLE: Investigating telomerase dynamics in live cells at a single-molecule level

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-C(02)M]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Organ Transplantation;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_CITY: MINNEAPOLIS

ORG_NAME: HENNEPIN HEALTHCARE RESEARCH INSTITUTE

ORG_STATE: MN

PHR: Project Narrative Significant racial disparities in organ donation impact health outcomes for patients in need of a transplant. Organizations that are best suited to engage local communities to increase awareness and support for organ donation often lack a research and data infrastructure to monitor organ donation disparities and guide continuous improvement. A Learning Health System model can provide equity-focused data resources to support local interventions to reduce organ donation disparities.

PI_NAMEs: SCHAFFHAUSEN, CORY R (contact)

PROJECT_TERMS: access disparities;Affect;Awareness;Biological Models;Collaborations;Communities;community engagement;community intervention;Community Outreach;County;Coupled;dashboard;Data;data infrastructure;data resource;data tools;demographics;Disparity;disparity reduction;Education;Educational workshop;effective intervention;Effectiveness;effectiveness evaluation;Equity;Ethnic Origin;Ethnic Population;experience;Face;family support;Feedback;Geography;Goals;Great Plains;Health;health disparity;Health Service Area;Health Services;Health system;implementation framework;implementation outcomes;improved;Individual;interdisciplinary collaboration;Intervention;intervention refinement;Interview;iterative design;Kidney Transplantation;Learning;Link;liver transplantation;Medical;Methods;Minnesota;Minority;Monitor;mortality;Native American community;Native Americans;North Dakota;Organ;Organ Donations;Organ Donor;Organ failure;Organ Procurements;Organ Transplantation;Outcome;Patient-Focused Outcomes;Patients;Performance;Phase;Population;Process;Professional Organizations;programs;Protocols documentation;Quality of life;Questionnaires;Race;racial disparity;racial population;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Relationship-Building;Reporting;Research;Research Infrastructure;Research Personnel;Resources;Solid;South Dakota;Standardization;Surveys;System;System for Public Use;Therapeutic;Thinking;Time trend;Tissue Donations;Transplant Recipients;transplant registry;Transplantation;tribal community;Trust;underserved community;United States;Waiting Lists;Work

PROJECT_TITLE: A Learning Health System to increase organ donation and equity in populations experiencing health disparities


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Cloud computing promises to scale up storage, analysis and sharing of health data needed to accelerate research in genomics and precision medicine but methods for evaluating how responsible access to and sharing of genomic data is governed in the cloud remain severely underdeveloped. The proposed K01 aims to develop, validate, and implement a reliable tool in partnership with global stakeholders to assess genomic data stewardship across publicly funded repositories worldwide. Findings from this project will expand current strategies for ensuring stewardship systems reinforce community values and proposes a transparent model for reporting stewardship impact among cloud-native repositories going forward.

PI_NAMEs: RAHIMZADEH, VASILIKI  (contact)

PROGRAM_OFFICER_NAME: LOCKHART, NICOLE C

PROJECT_TERMS: Acceleration;Address;Algorithms;Assessment tool;Bioethics;Bioethics Consultants;Biomedical Research;Calibration;career;career development;Clinical;cloud based;Cloud Computing;Cloud Service;cognitive interview;Committee Members;Communities;Competence;Complex;Computer software;computerized tools;Consensus;Data;data access;Data Collection;data infrastructure;data management;data privacy;Data Protection;data resource;Data Science;Data Scientist;Data Security;Data Set;data sharing;Delphi Study;design;Development Plans;diverse data;Engineering;Ensure;Environment;ethical, legal, and social implication;Ethnic Population;evidence base;FAIR principles;Funding;Future;genome repository;genome resource;genomic data;Genomic medicine;Genomics;Goals;Health;health data;Health Policy;Human;implementation tool;improved;Individual;innovation;Institution;Institutional Practice;interest;International;Knowledge;Laws;Life Cycle Stages;Measures;Medical center;Medical Ethics;meetings;Mentored Research Scientist Development Award;Mentors;Methods;migration;Modeling;National Human Genome Research Institute;novel;Outcome;Outcome Measure;Output;Participant;Patients;Persons;pilot test;Policies;Population;precision medicine;preference;prevent;Privacy;privacy preservation;Provider;public trust;Published Comment;racial minority population;Reporting;repository;Research;Research Design;Research Personnel;scale up;Scientist;Secure;Security;service providers;Software Engineering;Strategic vision;Surveys;System;Technology;Testing;Time;tool;Training;Translating;trustworthiness;usability;Woman

PROJECT_TITLE: Implementation of an impact assessment tool to optimize responsible stewardship of genomic data in the cloud


NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Natural Products;Nutrition;Prevention;Racial and Ethnic Minority Health Research

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE Herbal and dietary supplement induced liver injury may be on the rise. Our research will identify supplements that cause liver injury and document how commonly injury occurs in the population. Through our collaboration with other organizations we will understand how injury from supplements occurs and we will promote supplement safety.

PI_NAMEs: HALEGOUA-DEMARZIO, DINA  (contact)

PROJECT_TERMS: Acute;Acute Disease;acute drug induced liver toxicity;Address;Ancillary Study;Biochemical;Biologic Characteristic;Biological;Botanicals;Chemical Injury;Chemicals;Chronic;Chronic Disease;Clinical;Clinical Trials;Collaborations;Consensus;cytokine;Delaware;design;Detection;Development;dietary supplements;drug induced liver injury;Enrollment;Epidemiology;ethnic difference;Etiology;Feasibility Studies;Foundations;Future;Genetic study;Grant;health care service organization;Health system;Hepatotoxicity;Herbal supplement;Histologic;Human;Immunologics;improved;In Vitro;Incidence;Injury;innovation;Investigation;liver injury;Managed Care;Medical;Minority Groups;National Toxicology Program;Natural Products;Ownership;Participant;participant enrollment;patient population;Patient Recruitments;Pediatric Hospitals;Pennsylvania;Pharmaceutical Preparations;pharmacovigilance;Pilot Projects;Population;Population Study;Procedures;prospective;Protocols documentation;Provider;Publishing;racial difference;recruit;Reporting;repository;Research;Research Personnel;Resources;response;Safety;Site;System;Techniques;Therapeutic Trials;timeline;Toxicity Tests;Toxicology;Underrepresented Minority;Update;validation studies;Work

PROJECT_TITLE: Herbal and Dietary Supplement Induced Liver Injury in the U.S.


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Precision Medicine

ORG_DEPT: PATHOLOGY

PHR: Project Narrative Our goal is to develop the next generation of T cell therapies for adult solid tumors. Recent advances in CRISPR- Cas9 technology allow investigators to design better and safer T cell products for adoptive cell therapy. An outstanding team of investigators has been assembled to develop a new TCR-T cell therapy directed to mutant KRAS that overcomes the critical challenges posed by the tumor microenvironment and T cell exhaustion. Laboratory correlatives using state-of-the art single cell technologies will be employed to investigate mechanisms of response and resistance after treatment. In this personalized medicine-based strategy, we estimate that 5,000 new adult cancer patients in the US per year will be eligible for this cell therapy.

PI_NAMEs: CARRENO, BEATRIZ M. (contact);JUNE, CARL H.;LINETTE, GERALD P

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Ablation;Address;Adoptive Cell Transfers;Adult;Aftercare;Alleles;base editing;biomarker development;biomarker discovery;Biotechnology;cancer clinical trial;Cancer Patient;Case Study;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell growth;Cell Proliferation;Cell Therapy;Cells;Cellular immunotherapy;Clinic;Clinical;clinical translation;Clinical Trials;Codon Nucleotides;Collaborations;Correlative Study;cost;CRISPR/Cas technology;Data;design;Development;DNA Sequence Alteration;Dose;Drug Combinations;Effector Cell;Eligibility Determination;engineered T cells;Engineering;Ensure;Epitopes;exhaustion;gene editing technology;Gene Modified;gene-editing approach;Genes;Genetic Transcription;Genomics;Goals;HLA-A gene;HLA-C Antigens;Human;Immune;Immune system;Immune Targeting;Immunology;Immunooncology;improved;In Vitro;in vivo;insight;KRAS2 gene;Laboratories;lead candidate;Lesion;Leukocytes;Malignant neoplasm of lung;Malignant Neoplasms;manufacture;Methods;Missense Mutation;molecular marker;molecular pathology;multi-site trial;mutant;Mutate;Myelogenous;Myeloid Cells;neoantigens;Neoplasm Circulating Cells;next generation;novel;Oncoproteins;Patients;pediatric patients;Pennsylvania;peripheral blood;personalized medicine;Pharmacologic Substance;phase 1 study;Phenotype;Population;premalignant;Productivity;Proteomics;Publishing;Rattus;Reagent;receptor;Recurrence;Research;research clinical testing;Research Personnel;Resistance;resistance mechanism;Resources;response;Safety;safety engineering;Sarcoma;single cell technology;Site;small molecule inhibitor;Solid Neoplasm;success;T cell infiltration;T cell therapy;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;targeted treatment;technological innovation;Technology Transfer;Testing;Translations;tumor;Tumor Antigens;tumor microenvironment;Universities;Variant;Vertebral column;Virus;Work

PROJECT_TITLE: Next generation T cell therapies for mutant KRAS solid tumors


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: STANFORD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Extracellular matrix stiffness and viscoelasticity regulates cell proliferation in 3D microenvironments through mechanotransduction, but the mechanisms mediating these effects remain largely unclear. Here we will combine biophysical approaches with genome-wide analyses and CRISPR screens to determine the mechanisms mediating the impact of matrix stiffness and viscoelasticity on cell proliferation. Therefore, the proposed research is relevant to the part of NIH’s mission that seeks to develop fundamental knowledge that will help reduce the burdens of human disability and disease.

PI_NAMEs: CHAUDHURI, OVIJIT  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: 3-Dimensional;Actomyosin;Address;Adherent Culture;Adhesions;Adhesives;Alginates;ATAC-seq;Automobile Driving;Basement membrane;Binding;Biocompatible Materials;Bioinformatics;Biological Assay;Biological Process;Biophysical Process;biophysical techniques;Biophysics;Breast Epithelial Cells;cancer cell;Cell Adhesion;cell behavior;Cell Proliferation;Cell Volumes;Cells;Characteristics;Chromatin;Collagen Type I;CRISPR screen;CRISPR/Cas technology;Data;density;Deposition;disability;Disease;Elasticity;Epigenetic Process;epigenetic regulation;epigenome;Epithelial Cells;Exhibits;Extracellular Matrix;Fibroblasts;Gene Expression;Genes;Genetic Transcription;genome-wide;genome-wide analysis;Goals;Human;Hydrogels;in vivo;innovation;Integrin Binding;Integrins;Ion Channel;Knock-out;Knowledge;Ligands;Liquid substance;MAP Kinase Gene;Mechanics;mechanotransduction;Mediating;Mesenchymal Stem Cells;migration;Mission;Molecular;Molecular Analysis;Morphogenesis;novel;Pathway interactions;PIK3CG gene;Process;Proliferating;reconstitution;Regulation;Relaxation;Research;response;Role;Signal Pathway;Solid;Sp1 Transcription Factor;stem cell differentiation;Stress;three dimensional cell culture;Tissues;tool;Transcriptional Regulation;transcriptome sequencing;United States National Institutes of Health;viscoelasticity;Viscosity;whole genome;Work

PROJECT_TITLE: Regulation of Adherent Cell Proliferation by Matrix Viscoelasticity

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: PHARMACOLOGY

PHR: Neuroscientists commonly use viral vectors as tools to evaluate how diverse brain cell types function and interconnect in animals and in models of neurological, neurodevelopmental, and neurodegenerative disorders. Moreover, viral vectors are increasingly being used to shuttle replacement genes and other molecules into brain cells to treat brain disorders. The BRAIN Viral Vector Service and Distribution Core will serve as a national resource for the distribution of high- quality viral vectors tailored specifically to neuroscientists working on topics relevant to the BRAIN Initiative and enable neuroscientists to pioneer new viral vector-based treatments for brain disorders.

PI_NAMEs: RITOLA, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: adeno-associated viral vector;Animals;base;Biological Sciences;Biology;Biomanufacturing;Biotechnology;Brain;brain cell;Brain Diseases;BRAIN initiative;brain research;Capsid;Cell Therapy;cell type;Client;Collaborations;Communities;cost;Country;Custom;Dependovirus;design;Development;education resources;Educational workshop;Equipment;experience;experimental study;gene replacement;gene therapy;Genome;Goals;Human Resources;improved;in vivo;International;Letters;Maintenance;manufacture;Medical;Mission;Nervous System Disorder;neural circuit;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurological Models;neuronal circuitry;Neurosciences;North Carolina;Performance;pre-clinical;Preparation;Privatization;Production;promoter;Protocols documentation;Quality Control;Rabies;rabies viral tracing;Rabies virus;Ramp;Reagent;recombinase;repository;Research;Research Personnel;Resources;sensor;Services;skills;Source;success;Synapses;System;tool;Training and Education;Translating;translational study;Universities;Validation;vector;Vendor;Viral;Viral Vector;Virus;Work

PROJECT_TITLE: BRAIN Viral Vector Services and Distribution Core


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: DAVIS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The primary goal of this cooperative agreement proposal is to continue the comprehensive food safety partnership between the Food and Drug Administration (FDA) and the Western Center for Food Safety (WCFS) at UC Davis. Similar to the past 15 years, WCFS will partner with FDA on conducting joint collaborative research projects, provide extension and technical assistance to agricultural communities, and assist FDA in implementing the Food Safety Modernization Act standards associated with the produce safety and preventive controls regulation. As a result of these efforts, the risk of foodborne microbial contamination of produce for the U.S. consumer will be reduced, thereby improving public health and the safety of the nation's food supply.

PI_NAMEs: ATWILL, EDWARD ROBERT (contact)

PROGRAM_OFFICER_NAME: ASSAR, SAMIR

PROJECT_TITLE: Cooperative Agreement to Support the Western Center for Food Safety


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Prostate cancer is the most common serious cancer diagnosed in men in the United States, and a leading cause of cancer mortality. This proposal is focused on understanding whether prostate cancer emerges from inflamed regions of the prostate, and in the process, gains the ability to evade the immune system. Through this research we will identify new ways to prevent and intercept the development of aggressive prostate cancer.

PI_NAMEs: DE MARZO, ANGELO MICHAEL (contact);YEGNASUBRAMANIAN, SRINIVASAN

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Acute;adaptive immune response;adaptive immunity;Address;Aging;Animal Model;anti-cancer;Atrophic;Basic Science;cancer cell;cancer diagnosis;Cancer Etiology;cancer initiation;Cancer Model;carcinogenesis;carcinogenicity;Carcinoma;Cell Death;cell injury;Cell Proliferation;Cells;Characteristics;Chronic;Clinical;Development;Disease;Disease Outcome;Disease Progression;disorder control;DNA Sequence Alteration;Environmental Risk Factor;Epidemiology;Epigenetic Process;epigenetic silencing;epigenomics;FDA approved;fibroblast-activating factor;Fibroblasts;FOLH1 gene;Genes;Genetic;Genome;Genomics;Gleason Grade for Prostate Cancer;Growth;Heterogeneity;high risk men;human tissue;Image;imaging agent;Imaging technology;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immune system;Immunologic Surveillance;immunoreaction;Immunotherapy;improved;Inflammation;Inflammatory;Innate Immune Response;innovation;Intercept;Lesion;Life Style;Link;Localized Disease;Longitudinal Studies;Macrophage;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metastatic Neoplasm to Lymph Nodes;Metastatic Prostate Cancer;microbial;Molecular;molecular imaging;mortality;mouse model;Mus;Mutation;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic;neoplastic cell;Noninfiltrating Intraductal Carcinoma;Outcome;Pathologic;PET/CT scan;Phase;Population;Positron-Emission Tomography;preneoplastic cell;prevent;Process;programmed cell death ligand 1;prospective;Prostate;prostate cancer cell;prostate cancer progression;prostate carcinogenesis;Prostate carcinoma;Prostatectomy;Prostatic;PTEN gene;recruit;Research;Research Project Grants;Resource Sharing;response;Risk;Role;Signal Transduction;stem;synergism;Testing;Therapeutic;Tissue Sample;Tissues;TP53 gene;translational study;tumor;tumor microenvironment;United States;Up-Regulation;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: Prostate inflammatory lesions as a proving ground for development of aggressive prostate cancer


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

PI_NAMEs: DE MARZO, ANGELO MICHAEL (contact)

PROJECT_TERMS: Address;anti-cancer research;Atlases;Basic Science;carcinogenesis;Collaborations;Communication;Communities;Data Analyses;Data Collection;Data Coordinating Center;Development;Discipline;diverse data;DNA Methylation;Electronic Mail;Evaluation;Evolution;Fostering;Funding;Genomics;graduate student;Grant;GSTP1 gene;Human Resources;Individual;Indolent;Inflammation;Inflammatory;Infrastructure;Institution;interdisciplinary approach;Joints;Knowledge;Leadership;Lesion;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;Mentors;Mission;Modality;Molecular and Cellular Biology;molecular pathology;mouse model;Neoplasms;Peer Review;Postdoctoral Fellow;pre-clinical;Procedures;programs;Progress Reports;Prostate;Prostatic;Publications;Research;Research Activity;Research Personnel;Research Project Grants;Role;Site Visit;Students;Summary Reports;support network;synergism;Teleconferences;Telephone;transcriptome sequencing;translational approach;tumor microenvironment;virtual;Work;working group

PROJECT_TITLE: TBEL Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

PROJECT_TERMS: Acute;Adenocarcinoma;Architecture;Attention;Benign;biological adaptation to stress;cancer initiation;Carcinoma;cell injury;Cell Nucleus;Cells;Chromatin;Chronic;Coupled;Data;Development;DNA;DNA Methylation;DNA Sequence Alteration;Engineering;Epigenetic Process;epigenetic silencing;epigenomics;Epithelial Cells;Equilibrium;Frozen Sections;Future;Gene Activation;Gene Expression;Genes;Genetic;genome sequencing;Genomics;Growth;GSTP1 gene;Human;Hypermethylation;imaging agent;Immune;immune activation;Immune response;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Infiltrate;inhibitor;Interleukin-1 beta;Knock-out;laser capture microdissection;Lesion;Lymphoid Cell;Macrophage;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Metastatic Prostate Cancer;Modeling;Molecular;mouse model;multimodality;Mus;Myeloid-derived suppressor cells;Neoplasms;neoplastic;neoplastic cell;novel;overexpression;Pattern;pharmacologic;Phase;Positron-Emission Tomography;promoter;Prostate;Prostate Adenocarcinoma;Prostatic;PTGS2 gene;Publishing;recruit;Regulatory T-Lymphocyte;Sampling;Signal Transduction;single nucleus RNA-sequencing;Stimulator of Interferon Genes;Stress;synergism;Testing;Tissues;transcriptome sequencing;Up-Regulation;Variant;whole genome;XCL1 gene

PROJECT_TITLE: Elucidating and testing causal drivers of inflammation triggered prostatic early lesions


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Networking and Information Technology R&D (NITRD);Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative The workforce in data science and STEM continues to lack representation by key groups: women, minorities, and those from rural and lower socio-economic backgrounds. This novel, experiential problem-based learning approach uses population-based Big Data to engage diverse middle school students to apply real data to solve real community health problems. The goal of the Data Detectives SEPA program is to promote greater diversity in the future science and STEM workforce through an informal science education curriculum focused on data sciences and application to community health issues.

PI_NAMEs: GILLESPIE, THERESA W (contact);MARCUS, ADAM I.

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Active Learning;Address;Applied Research;Area;Attitude;Big Data;Biological;Biomedical Technology;Black race;career;clinical care;cohort;Communities;Community Health;community partners;complex data;Computerized Medical Record;COVID-19 pandemic;Creativeness;Data;Data Science;Data Set;Data Sources;Digital Libraries;direct application;Economics;Education;education research;Educational Curriculum;Educational process of instructing;Environment;Evaluation;Evaluation and Analysis Planning;Exercise;experience;Female;Foundations;Future;Genomics;Geography;Goals;Health;health assessment;health disparity;health equity;Hispanic;Image;improved;innovation;junior high school;K-12 Education;K-12 student;Knowledge;Laboratories;Life Style;Literature;Malignant Neoplasms;mathematics content;Measures;Mentors;metabolomics;Methods;Middle School Student;Minority;Minority Groups;Modeling;Motivation;National Institute of General Medical Sciences;Nature;Needs Assessment;novel;Outcome;Patient Care;Physiological;Policies;Population;population based;Positioning Attribute;Problem-Based Learning;Program Evaluation;programs;Proteomics;Qualitative Evaluations;Quantitative Evaluations;recruit;Reproducibility;Research;Rural;Rural Community;Rural Population;Schools;Science;science education;Self Efficacy;skills;social health determinants;socioeconomics;STEM career;STEM field;student participation;Students;tool;Translating;Underrepresented Minority;Underrepresented Students;Woman

PROJECT_TITLE: Data Detectives: Using Real Data to Solve Real Community Health Problems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

PI_NAMEs: POMPER, MARTIN G (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Animals;Appearance;Architecture;Area;Atrophic;Benign;Carcinoma;cell type;Cells;Chronic;Clinical;Clinical Research;combat;Consent;Cytotoxic T-Lymphocytes;Data;design;Development;Disease;Disease Outcome;epigenomics;Epithelial-Stromal Communication;fibroblast-activating factor;Fibroblasts;FOLH1 gene;Future;Gene Expression;Genetic;Genome;Genomics;Gland;Gleason Grade for Prostate Cancer;Goals;Heterogeneity;high risk;Histopathology;Human;Image;Image Analysis;image translation;imaging agent;imaging biomarker;Immune;Immunohistochemistry;indexing;Inflammation;Inflammatory;Intercept;Lesion;Link;Longitudinal Studies;Machine Learning;Macrophage;Macrophage Colony-Stimulating Factor Receptor;Magnetic Resonance Imaging;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Measures;mouse model;multimodality;Mutation;Neoplasm Metastasis;neoplastic cell;Noninfiltrating Intraductal Carcinoma;novel;Outcome;Pathologic;Pathology;Patient imaging;patient subsets;Patients;Pattern;permissiveness;Phenotype;Positron-Emission Tomography;Primary Neoplasm;prognostic;prospective;Prostate;prostate cancer model;prostate cancer risk;Prostate carcinoma;Prostatectomy;Prostatic;PTEN gene;Radiochemistry;Radiology Specialty;radiomics;Regulatory T-Lymphocyte;Series;Signal Transduction;Signaling Protein;Staging;Stains;standard of care;Testing;Time;TP53 gene;translational goal;tumor;Tumor Markers;tumor microenvironment;whole slide imaging;X-Ray Computed Tomography

PROJECT_TITLE: Translational imaging biomarkers of the tumor microenvironment in early prostate cancer