NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Pediatric;Prevention;Suicide;Suicide Prevention

PHR: PROJECT NARRATIVE Suicide is a serious public health crisis and a leading cause of death in children, and those whose mothers have a history of suicidal behavior are especially vulnerable to an early and persistent course of suicidal thoughts and behaviors. Results from this study will advance understanding of emotion regulation as one intergenerational mechanism of suicide risk transmission while simultaneously testing a prevention and intervention model to mitigate suicide risk at the level of the mother-child dyad. The ultimate impact of this work is to inform improved, evidence-based assessment tools and identify new targets for prevention and early intervention strategies to reduce suicide risk and improve psychosocial functioning in vulnerable children.

PI_NAMEs: STEPP, STEPHANIE D (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: 11 year old;Address;Adolescence;Affect;Age;Assessment tool;Caregivers;Cause of Death;Child;Child Development;Childhood;Clinical;clinically significant;combat;completed suicide;Development;Dialectical behavior therapy;early adolescence;early childhood;Early Intervention;emerging adult;emotion regulation;Emotional;Emotions;Enrollment;Etiology;evidence base;expectation;experience;Exposure to;Family;Fathers;Feeling suicidal;follow-up;Heritability;high risk;ideation;improved;intergenerational;Intervention;Maternal Behavior;Measures;Mediator;Mental Health;Methods;Modeling;Mothers;multimodality;Nursery Schools;offspring;Outcome;Participant;Pathway interactions;post intervention;Prevention;Prevention approach;preventive intervention;Process;Psychopathology;psychosocial;Public Health;Randomized;Randomized, Controlled Trials;Recording of previous events;reducing suicide;Research;response;Risk;Risk Behaviors;Risk Factors;Safety;Shapes;skills;skills training;Socialization;suicidal behavior;suicidal risk;Suicide;suicide model;suicide rate;Testing;theories;Time;transmission process;Trauma;treatment as usual;Validation;Vertical Disease Transmission;Vulnerable Populations;Woman;Work;Youth

PROJECT_TITLE: Testing Emotion Regulation as an Intergenerational Mechanism of Suicide Risk in Mother-Child Dyads

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: EB

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative 7T MRI image quality is degraded by inhomogeneities in the static B0 and transmit B1+ fields, which reduce its overall diagnostic value and slows its translation to clinics. The B0 and B1+ problems have so far been approached independently, thus yielding two separate hardware solutions, namely multi-coil (MC) shim arrays for B0 shimming and parallel transmission (pTx) for flip-angle control, that are expensive and difficult to integrate and operate. We propose a new class of excitation pulses that leverage the degrees-of-freedom of MC shim arrays to homogenize the flip-angle distribution at 7T, thus yielding an integrated solution for both B0 and flip-angle shimming that is cheaper and bypasses the complex safety management of pTx, and may therefore be more readily deployed in clinics.

PI_NAMEs: GUERIN, BASTIEN  (contact);STOCKMANN, JASON P

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: absorption;Address;Affect;Air;Amplifiers;Biomedical Engineering;Brain;Brain Neoplasms;Bypass;Cerebellum;Clinic;Clinical;Clinical Protocols;Clinical Research;clinical translation;Complex;Consumption;contrast imaging;Cortical Dysplasia;cost;cost comparison;Databases;design;Detection;diagnostic value;Dropout;Electromagnetics;Evaluation;External auditory canal;Freedom;Friends;frontal lobe;Head;Health;Heterogeneity;Image;improved;Individual;individual variation;Inherited;innovation;instrument;Lesion;Magnetic Resonance Imaging;Maps;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;Noise;operation;Patients;Performance;Physiologic pulse;Play;Preparation;programs;Radiology Specialty;Research;Research Personnel;Resolution;RF coil;Running;Safety;Safety Management;Shapes;Signal Transduction;simulation;Sinus;Slice;Spatial Distribution;System;Technology;Temporal Lobe;Temporal Lobe Epilepsy;Testing;Time;tool;Translating;Translations;transmission process;tumor;Update;Validation

PROJECT_TITLE: Integrated, dynamic B0 and flip-angle shimming using multi-coil shim arrays

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Interstitial Cystitis;Urologic Diseases

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Narrative: This project seeks to understand the details of how Cav1.2 calcium channel in urothelium modulates bladder storage and voiding functions. This study is important for the understanding of bladder pathologies, and will potentially lead to novel therapeutics to treat patients with bladder dysfunctions.

PI_NAMEs: YU, WEIQUN  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Ablation;Adenoviruses;Adenylate Cyclase;Agonist;antagonist;apical membrane;ATP Hydrolysis;Bladder;Bladder Dysfunction;Calcium Channel Blockers;calcium intake;Cardiac Myocytes;Cell membrane;Cells;Cellular Morphology;Clinical;Clinical Treatment;Clinical Trials;Communication;Coupling;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cystitis;Data;Dependence;Drug Targeting;Electrophysiology (science);Epidemiologist;Exhibits;Exocytosis;extracellular;Frequencies;Functional disorder;Gene Expression;Gene Silencing;Genetic;Human;Hydrolase;hypertension control;Impairment;Incontinence;Infusion procedures;Interstitial Cystitis;intravesical;Ketamine;knock-down;Knock-in;L-type calcium channel alpha(1C);lower urinary tract symptoms;Mediating;Molecular;mouse model;Mus;Muscle;Muscle Contraction;Nature;Nifedipine;Nocturia;novel;novel therapeutic intervention;novel therapeutics;Overactive Bladder;Pathogenesis;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphorylation;Physiology;Reporting;Role;Severities;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Stretching;symptom treatment;Symptoms;targeted treatment;Techniques;Testing;Therapeutic;urinary;Urinary Incontinence;Urination;Urine;Urodynamics;urologic;Urothelium;Visualization;voltage;Wild Type Mouse

PROJECT_TITLE: Cav1.2 in bladder physiology and pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (05)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative Confocal endo-microscopy is a powerful tool for high-resolution imaging of cells and tissues inside the body, allowing for high-sensitivity and high-specificity diagnosis of diseases, including cancer. However, current confocal endo-microscope probes are made of discrete bulky optical elements and require scanning, resulting in slow imaging speed and large size and thus hindering their broader utility. The goal of the proposed research is to overcome these limitations by developing a metasurface based chromatic confocal endo-microscope, which promises to enhance medical imaging and enable fast, minimally invasive diagnosis of diseases deep within the body.

PI_NAMEs: LIU, ZHIWEN  (contact);NI, XINGJIE

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Address;Algorithms;analog;Architecture;Area;cantilever;Cells;cellular imaging;confocal imaging;cost;design;detector;Devices;Diagnosis;diagnostic tool;Diameter;disease diagnosis;Distal;Elements;Endoscopes;Endoscopy;Engineering;fabrication;Fiber;Goals;Health;high resolution imaging;Image;Imaging Device;Imaging Phantoms;imaging system;large scale production;Lateral;lens;Light;Lighting;Malignant Neoplasms;Measurement;Measures;Mechanics;Medical Imaging;Methods;microendoscopy;Microscope;microscopic imaging;Microscopy;miniaturized device;minimally invasive;Morphologic artifacts;Motion;Nanostructures;novel;Optics;Performance;photonics;Positioning Attribute;programs;Property;real-time images;reconstruction;Research;Resolution;Sampling;Scanning;Screening for cancer;Series;Shapes;Silicon Dioxide;Source;Specificity;Speed;Spottings;System;Technology;Three-Dimensional Imaging;Time;tissue phantom;Tissues;tool;Tube;two-dimensional;Work

PROJECT_TITLE: Metasurface based chromatic confocal endoscope

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Neurosciences;Pain Research

ORG_CITY: SEATTLE

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative This will be the first fully-powered clinical trial that will use formal tests of both mediation and moderation to identify the neuromodulatory mechanisms of mindfulness meditation and self-hypnosis relative to a control condition for reducing chronic pain intensity in older adults. The study findings will benefit the health of older adults by providing an empirical basis for streamlining these evidence-based interventions, which will reduce the burden of chronic pain, and provide an effective non-pharmacological alternative to opioids. Moreover, advancing our knowledge of treatment moderators will inform precision medicine and the development of patient-treatment matching algorithms which will optimize both treatment efficacy and efficiency.

PI_NAMEs: DAY, MELISSA ANNE;JENSEN, MARK P (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Absence of pain sensation;Adult;Affect;Aftercare;Age Years;Aging;Algorithms;American;Anterior;arm;arterial spin labeling;attentional control;Biological Assay;Brain;Brain imaging;central pain;Characteristics;Chronic intense pain;chronic pain;chronic pain management;chronic painful condition;cingulate cortex;clinical pain;Clinical Trials;cognitive reappraisal;cost effectiveness;Data;design;Development;efficacious intervention;Electroencephalography;emotion regulation;Enrollment;Evaluation;evidence base;Evidence based intervention;experience;falls;Fracture;Functional Magnetic Resonance Imaging;Health Benefit;Hypnosis;improved;Individual;innovation;Insula of Reil;Intervention;Knowledge;Mechanics;Medial;Mediating;Mediation;Mediator;mindfulness meditation;mortality;multimodality;Musculoskeletal;Neurobiology;Neuropathy;neurophysiology;neuroregulation;normal aging;older adult;Older Population;Opioid;opioid use;Outcome;Pain;pain catastrophizing;pain chronification;Pain management;pain model;pain outcome;pain reduction;Participant;Pathway interactions;Patients;Perfusion;Population;precision medicine;predicting response;Prefrontal Cortex;Preventive Medicine;primary outcome;psychologic;Public Health;randomized trial;Research;response;Role;Sensory;somatosensory;Somatosensory Cortex;Stimulus;Structure of superior frontal gyrus;Testing;Thalamic structure;Training;Treatment Efficacy;Treatment outcome;Work

PROJECT_TITLE: Mechanisms of Mindfulness Meditation and Self-Hypnosis for Pain in Older Adults with Chronic Pain

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Pediatric;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The objective of this study is to test the hypothesis that disturbed sleep is a modifiable, bio- behavioral mechanism contributing to impaired vascular function and increased CVD risk among young adults with exposure to Adverse Childhood Experiences (ACEs). We propose an innovative, robust hybrid approach to objectively quantify the degree to which lower sleep quality contributes to ACEs-related endothelial dysfunction, inflammation, and oxidative stress in young adults, and to determine if improved sleep quality is causally related to improvements in vascular function among young adults with ACEs. These findings will provide the critical groundwork needed to develop therapeutic strategies to improve CVD risk in individuals with exposure to ACEs.

PI_NAMEs: JENKINS, NATHANIEL D.M. (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: actigraphy;Adult;adverse childhood events;Adverse event;Affect;Anxiety;Behavioral;behavioral sleep intervention;biobehavior;Biological Assay;Biopsy;Blood Pressure;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Clinical;Cognitive Therapy;cohort;Communities;Data;Development;Dose;early life stress;early onset;effective intervention;emerging adult;Endothelial Cells;endothelial dysfunction;Endothelium;Exhibits;experience;Exposure to;Functional disorder;Future;Goals;health disparity;Home;Household;Human;Hybrids;Impairment;improved;improvement on sleep;In Vitro;in vivo;Individual;Inflammation;innovation;Intervention;Life;Life Cycle Stages;Link;Measures;Mediating;Mental Depression;Morbidity - disease rate;mortality;Myocardial Ischemia;neglect;novel;Outcome Study;Oxidative Stress;Pathway interactions;Patient Self-Report;Polysomnography;poor sleep;pre-clinical;prognostic;prognostic indicator;psychosocial;psychosocial stressors;Randomized;Reporting;Research;response;Risk;Risk Factors;Role;screening;Sleep;Sleep disturbances;sleep health;sleep onset;sleep quality;sleep quantity;Sleeplessness;Slow-Wave Sleep;social determinants;Stroke;Testing;Therapeutic;traumatic event;United States National Institutes of Health;Vascular Diseases;vascular endothelial dysfunction;Vascular Endothelium;Wakefulness;Wrist;young adult

PROJECT_TITLE: Interactions of Adverse Childhood Experiences, Sleep Disruption, and Mechanistic Links to Vascular Dysfunction in Emerging Adults

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

PHR: PROJECT NARRATIVE The proposed research addresses the major public health issue of obesity by investigating the physiological role of signaling pathways downstream of the ghrelin receptor GHSR1a and their regulation by the accessory protein MRAP2. Thus, the proposed research is relevant to the NIH’s mission of pursuing fundamental knowledge to increase health and reduce illness.

PI_NAMEs: SEBAG, JULIEN ALBERT (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Address;Agonist;antagonist;Anti-Obesity Agents;Appetite Stimulants;Arrestins;beta-arrestin;Biological Assay;Blood Glucose;blood glucose regulation;Body Weight decreased;Brain;Cachexia;Cells;Chemosensitization;Complex;design;Development;diet-induced obesity;drug development;drug discovery;Drug Evaluation;Eating;Endocrine;Environment;feeding;Future;G-Protein-Coupled Receptors;Gene Silencing;Genetic;ghrelin;ghrelin receptor;GHS-R1a;Goals;growth hormone secretagogue receptor;GTP-Binding Proteins;Health;Hormones;Hunger;Hypothalamic structure;In Vitro;in vivo;Insulin;Integral Membrane Protein;Knowledge;Ligands;Measurement;Mediating;melanocortin receptor;Mission;mouse model;Mus;mutant;Mutate;Neurons;Obesity;obesity treatment;Pancreas;pharmacologic;Pharmacology;Phenotype;Physiological;Play;Proteins;Public Health;Publishing;receptor;recruit;Regulation;Research;response;Role;Signal Pathway;Signal Transduction;Somatotrope Cell;Somatotropin;Starvation;Stomach;Structure of nucleus infundibularis hypothalami;System;tool;trafficking;United States National Institutes of Health;Viral

PROJECT_TITLE: Investigating the requirement of MRAP2 for ghrelin function

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative The proposed research concerns the development of new chemical tools for reproducing physiologically or pathophysiologically relevant chemical modifications found on biomolecules and for identifying the disease- relevant targets of therapeutic agents in clinical development. Understanding the molecular basis of disease and development of therapeutics to treat those diseases is relevant to public health and falls under the NIH mission to seek fundamental knowledge about the nature of living systems and the application of that knowledge to enhancing health and reducing illness.

PI_NAMEs: KIM, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Affinity;anticancer activity;Arachidonate 5-Lipoxygenase;Biochemical;Biological;Biological Assay;biological systems;Biology;biophysical analysis;catalyst;chemical reaction;chemical synthesis;Chemicals;Chemistry;chemoproteomics;clinical development;Collection;Communities;Complex;Data;design;Development;Diazomethane;Disease;Dissociative disorder;drug candidate;Drug Delivery Systems;drug development;drug discovery;Drug Screening;Encapsulated;Enzymes;Event;Excision;experimental study;falls;FDA approved;functional group;Generations;Goals;halogenation;Health;Heme;improved;inhibitor therapy;innovation;interest;Knowledge;Label;Lead;Ligands;Ligation;Lipoxygenase Inhibitors;Mass Spectrum Analysis;Methods;Mission;Modification;Molecular;Molecular Target;Nature;operation;Organic Chemistry;Organism;Oxides;Pharmaceutical Preparations;Phenotype;Physiological;Positioning Attribute;Post-Translational Protein Processing;Preparation;programs;Property;Prostaglandin-Endoperoxide Synthase;Prosthesis;protein activation;protein complex;Proteins;Proteomics;Public Health;Radial;Reaction;Reagent;recruit;Research;Site;small molecule;Structure;System;targeted treatment;therapeutic development;tool;Ubiquitin;United States National Institutes of Health;Western Blotting

PROJECT_TITLE: Bioorthogonal methods for unveiling chemical reactivity

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative: Although many major psychiatric disorders have their onset in adults, there is increasing evidence that traumatic experiences early in life can predispose an individual to illness as adults. Moreover, males and females show different susceptibilities to pathologies as adults following peripubertal stress. We have found that major stressors delivered to male rats prepubertally versus females postpubertally, while acting similarly soon after the stress, show major differences in the pathways impacted as adults. We propose that this is due to differential regulation by the medial prefrontal cortex. By studying the factors that link differential stress susceptibility to stress-induced damage at the systems level, we hope to better understand why there are substantial differences in susceptibility to adult pathology based on sex, which may lead to more effective means for early intervention that may prevent the emergence of major psychiatric disorders later in life.

PI_NAMEs: GRACE, ANTHONY A (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Adolescent;Adult;Affect;Affective;Amygdaloid structure;Anxiety;Behavior;Brain;Brain region;Cell Nucleus;Cognitive;comparative;Corpus striatum structure;Data;designer receptors exclusively activated by designer drugs;Development;Disease;Dopamine;dopaminergic neuron;early experience;Early Intervention;Estrogen Replacements;experience;Exposure to;Female;Functional disorder;Hippocampus;Human;Hyperactivity;Individual;insight;Interneurons;Lateral;Lesion;Life;Link;male;Medial;Mental Depression;Mental disorders;Modeling;Motivation;neuron loss;Neurons;Nucleus Accumbens;Outcome;Ovariectomy;Parvalbumins;Pathologic;Pathology;Pathway interactions;peripubertal period;Predisposition;Prefrontal Cortex;prepuberty;prevent;Process;Productivity;Puberty;Rattus;Regulation;response;Reuniens Thalamic Nucleus;Schizophrenia;sex;Sex Differences;Stains;Stress;stressor;System;Testing;Thalamic Nuclei;Thalamic structure;Ventral Tegmental Area;women's prevention

PROJECT_TITLE: Gating of Information Flow Within the Nucleus Accumbens

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Hematology;Osteoporosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: NARRATIVE This multidisciplinary research project will advance our understanding of the bone marrow microenvironment that supports blood cell formation by examining the heterogeneity, clonality, and network activity of the bone marrow stromal cells.

PI_NAMEs: LIN, CHARLES P. (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: 3-Dimensional;acute myeloid leukemia cell;Address;Adult;aged;Architecture;Bar Codes;Biological Assay;Blood Cells;bone;bone fracture repair;bone imaging;bone loss;Bone Marrow;Bone Marrow Cells;Bone remodeling;Calcium;Calcium Oscillations;Calcium Signaling;Cell Physiology;cell type;Cells;Classification;clinically relevant;Clonal Expansion;Clonality;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;CSF3 gene;Cyclophosphamide;Data;Deposition;differential expression;Elements;Endowment;Environment;Frequencies;Genes;Hematopoiesis;Hematopoietic;hematopoietic stem cell expansion;hematopoietic stem cell niche;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Heterogeneity;Image;image guided;in vivo;Individual;Inflammatory;insight;Interdisciplinary Study;Laboratories;Life;Link;Location;Maps;Methods;Microanatomy;Modeling;Molecular;Mus;Neurosciences;new technology;Osteoporotic;osteoporotic bone;Ovariectomy;Pattern;PF4 Gene;Population;Process;regeneration potential;Research Project Grants;response;Shapes;single-cell RNA sequencing;Source;Speed;Stromal Cell-Derived Factor 1;Stromal Cells;stromal progenitor;Supporting Cell;Testing;Text;Three-Dimensional Imaging;transcriptome;Transplantation

PROJECT_TITLE: Heterogeneity of bone marrow cavities shaping the hematopoietic microenvironment

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Infant Mortality;Lung;Neurosciences;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Prevention;Rare Diseases;Sleep Research;Sudden Infant Death Syndrome

ORG_CITY: CLEVELAND

ORG_DEPT: PEDIATRICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative: Sudden Unexpected Infant Death (SUID) is the leading cause of infant mortality up to one year of age. A significant proportion of the ~3,500 SUIDS per year in the US are classified as Sudden Infant Death Syndrome (SIDS). The cause of SIDS is complex, multifactorial, and remains largely unknown. Here we implement an animal model of SIDS to: 1) investigate new (and existing) central and peripheral neural mechanisms associated with mortality; 2) perform screening of blood and urine to discover several new biomarkers as potential predictors of infants at increased risk of SIDS; and 3) test a clinically approved drug that may be a novel prophylactic measure to prevent SIDS.

PI_NAMEs: MACFARLANE, PETER  (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: 1 year old;Adverse effects;Affect;Animal Model;Autonomic Dysfunction;Biological Markers;Blood;Blood Screening;Brain Stem;Carotid Body;Cause of Death;Cell Nucleus;Cessation of life;Chronic;chronic depression;Classification;Clinical;Complement;Complex;critical developmental period;critical period;Data;Denervation;Detection;diagnostic development;diagnostic tool;dorsal motor nucleus;Early identification;Environment;Exhibits;experience;Extracellular Matrix;Forensic Medicine;Functional disorder;gamma-Aminobutyric Acid;Gliosis;high risk infant;Human;Hyaluronan;Hypoxia;Infant;Infant Mortality;inhibitor;Intervention;Measures;Mediating;Microglia;Modeling;mortality;Nature;Neonatal;neonatal period;neonate;neurochemistry;neuromechanism;Neuronal Dysfunction;Neurotransmitters;novel;Operative Surgical Procedures;Peripheral;Pharmaceutical Preparations;pharmacologic;postnatal;postnatal development;predictive marker;prevent;Prevention;Preventive measure;prophylactic;Prophylactic treatment;Proteoglycan;Publishing;Rattus;Respiration;Respiration Disorders;respiratory;response;Risk;Role;Safety;Sensory;sensory input;Serotonin;Serum;stressor;Sudden infant death syndrome;Testing;Time;translational impact;Up-Regulation;Urine;Validation

PROJECT_TITLE: Central & Peripheral Mechanisms of Respiratory & Autonomic Control Dysfunction in a Novel Model of SIDS: Predictive Biomarkers and the Role of the Extracellular Matrix

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Maternal Health;Networking and Information Technology R&D (NITRD);Pediatric;Social Determinants of Health;Women's Health Research

ORG_CITY: STANFORD

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE By using machine learning in satellite imagery and other geotagged “big data” sources, this project has the potential to fundamentally change the measurement of maternal and child health indicators in low- and middle- income countries, providing up-to-date estimates for each village and neighborhood in a country. Until now, measurement of maternal and child health has relied on household surveys, which are expensive, conducted infrequently, and cover only a small fraction of all populations and areas in a country. This research is relevant to public health because it uses an inexpensive and scalable method that could enable the geographically precise targeting of interventions and up-to-date monitoring of changes in key maternal and child health indicators, and additionally lead to a low-cost approach for evaluating the effect of past policies and interventions on maternal and child health.

PI_NAMEs: BURKE, MARSHALL  (contact);GELDSETZER, PASCAL

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Acute respiratory infection;Age;Air Pollution;Anemia;antenatal;Area;Attention;Benchmarking;Big Data;Birth;care systems;Cessation of life;Charge;Child;Child Malnutrition;Child Mortality;Childhood;Code;Communities;Consumption;cost;Country;Data;data resource;Data Set;Data Sources;data visualization;Death Rate;Detection;Diarrhea;Electricity;Evaluation;Family Planning;Fever;Geographic Locations;Geography;Health;Health care facility;Health Status;Household;Image;Imagery;imaging approach;improved;Infrastructure;innovation;Intervention;Knowledge;Lead;low and middle-income countries;Machine Learning;machine learning model;Maps;Maternal and Child Health;Maternal Mortality;Maternal-Child Health Services;Measurement;Measures;Methods;Minority;Modeling;Monitor;Nature;neighborhood disadvantage;Neighborhoods;novel;novel strategies;Outcome;Performance;Pharmaceutical Preparations;Policies;Policy Maker;Population;Postnatal Care;Poverty;Prevalence;Public Health;Publications;Registries;remote communities;reproductive;Research;Research Personnel;Resolution;Sampling;Sanitation;Science;Series;skills;Source;success;Supplementation;Surface;Surveys;Techniques;Testing;Time;Training;Travel;Uncertainty;Update;Vaccination;Validation;Vitamin A;Water;water quality;Woman

PROJECT_TITLE: Machine learning in publicly available geotagged data to allow monitoring of maternal and child health

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Prevention;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Radiotherapy (RT) is an effective prostate cancer treatment that provides cures; however, radiotoxicity adversely impacts the lives of cancer survivors, most notably older patients. There are no predictive biomarkers associated with its incidence, nor are there durable therapies preventing radiotoxicity. Here, we investigate novel players, extracellular vesicles induced by RT, for their action, predictive power, and therapeutic targets for radiotoxicity.

PI_NAMEs: LEE, YI-FEN  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Activities of Daily Living;Affect;Amendment;Angiotensin-Converting Enzyme Inhibitors;Animals;Attention;Automobile Driving;Biogenesis;Biological Assay;Biological Markers;Biological Models;Bladder;Bladder Injury;Blood;Body Fluids;Cancer Patient;Cancer Survivor;cell injury;Cell Line;Cells;Cellular Stress;clinical investigation;clinical predictors;clinically relevant;Communication;Complication;cytokine;Development;Dimensions;Distant;DNA Damage;Early Diagnosis;Early Intervention;Enrollment;extracellular vesicles;Future;gain of function;Genes;genome wide association study;Hematuria;Human;Immunologics;In Vitro;in vivo;Incidence;intercellular communication;Investigation;Kinetics;Link;Lipid Binding;Lisinopril;loss of function;Malignant neoplasm of prostate;Mediating;Mediator;medical countermeasure;Membrane;Molecular;molecular diagnostics;Mus;nanoparticle;Natural Immunity;neutrophil;novel;Observational Study;older patient;Oxidative Stress;particle;Pathogenesis;Pathway interactions;Patients;Phase I Clinical Trials;Play;pre-clinical;preclinical study;predictive marker;preservation;prevent;Prevention;Process;Production;prognostic value;prospective;prostate cancer survivors;Prostate Cancer therapy;Proteins;Proteomics;Radiation;radiation cystitis;Radiation Protection;Radiation therapy;Radiation Toxicity;radioprotected;rapid detection;Reporting;Research;Risk;Role;Sampling;Secretory Vesicles;Serum;Small RNA;Symptoms;therapeutic target;therapy outcome;Time;Toxic effect;trafficking;transcriptome sequencing;Treatment-related toxicity;tumor microenvironment;urinary;Urine;Vesicle;vesicular release

PROJECT_TITLE: Clinical and pre-clinical investigation of extracellular vesicles as a mechanism of toxicity in the bladder of prostate cancer patients treated with radiotherapy

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunization;Immunotherapy;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: DETROIT

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Narrative We aim to inhibit tumor growth and prevent disease recurrence by blocking the molecules that facilitate cancer development. We will find these molecules in genetically engineered mice that resemble humans in their cancer development to allow for mapping of cancer facilitating molecules. We will test if blocking LILRB4, the first candidate molecule we found and verified with human cancer data, will boost immune response and inhibit tumor growth.

PI_NAMEs: JACOB, JENNIFER B (contact);KIDDER, BENJAMIN L

PROGRAM_OFFICER_NAME: GUNASEKHARAN, VIGNESH KUMAR

PROJECT_TERMS: Acceleration;Active Immunization;Age of Onset;Algorithms;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Atlas of Cancer Mortality in the United States;Binding;bioinformatics pipeline;Biological Assay;Biological Process;Breeding;Cancer Intervention;Cancer Patient;cancer risk;cancer survival;Cancer Vaccines;Candidate Disease Gene;candidate identification;carcinogenesis;Cell Line;Cells;Chromosomes;Clinical;Clinical Trials;Code;Data;Data Set;Development;disorder control;DNA;Enhancers;Equilibrium;ERBB2 gene;Fatty acid glycerol esters;Foundations;functional genomics;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic linkage analysis;Genetic Polymorphism;Genetically Engineered Mouse;Genome;genome wide association study;Genotype;Goals;Growth;Haplotypes;Human;Immune;immune activation;Immune response;Individual;Intercistronic Region;Intervention;Knock-out;Laboratories;Length;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;mammary;Mammary Neoplasms;Measures;Modeling;Monoclonal Antibody Therapy;mosaic;Mus;Mutation;Myelogenous;Myeloid Cells;Natural Killer Cells;neoplastic cell;Normal Cell;Oncogenes;Open Reading Frames;Outcome;Pathway Analysis;Phenotype;prevent;Production;Proteins;Quantitative Trait Loci;Rattus;Reagent;Recurrent disease;Regulator Genes;risk variant;Role;Signal Transduction;single-cell RNA sequencing;T-Lymphocyte;Testing;Tissue-Specific Gene Expression;transcription factor;transcriptomics;Transgenic Mice;Translational Research;tumor;Tumor Antigens;Tumor Expansion;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Suppressor Genes;vaccine response

PROJECT_TITLE: Defining Cancer Intervention Targets by Functional Genomics Analysis of Outbred F1 Mice

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-E (55)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

ORG_CITY: Bloomington

ORG_NAME: HEALTHPARTNERS INSTITUTE

ORG_STATE: MN

PHR: PROJECT NARRATIVE Soon after undergoing anterior cruciate ligament knee surgery, people often feel angry, sad, and frustrated, and may go on to experience fear and low confidence when it is time to play sports again. This study compares rehabilitation with exercise only to rehabilitation with exercise plus help from a clinician and educational videos to manage thoughts and feelings during recovery.

PI_NAMEs: CHMIELEWSKI, TERESE L (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Adherence;Adolescent and Young Adult;Anger;Anterior Cruciate Ligament;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;anterior cruciate ligament rupture;Athletic Injuries;Awareness;Behavior;Behavioral;biopsychosocial;Clinical;Clinical Practice Guideline;Cognition;Cognitive;Communication;Consultations;Depressed mood;Documentation;Education;efficacy evaluation;Emotions;Empathy;Equipment and supply inventories;Exercise;experience;Feeling;flexibility;follow-up;Fright;Frustration;Impairment;improved;inattention;Injury;innovation;International;Intervention;Knee;Knee Injuries;Knowledge;Link;Measures;Mentorship;Methods;Modeling;Motivation;Operative Surgical Procedures;Outcome;Patient Education;patient oriented;Patient Self-Report;patient-clinician communication;Patients;Persons;physical therapist;Play;Protocols documentation;Psyche structure;psychologic;Questionnaires;Randomized, Controlled Trials;Readiness;Recommendation;Reconstructive Surgical Procedures;Records;Recovery;Rehabilitation therapy;Research;response;return to sport;Self Efficacy;skills;Sports;Surveys;Techniques;Testing;Therapeutic;Thinking;Time;Training;treatment arm;Visit;Work

PROJECT_TITLE: ACL Reconstruction Rehabilitation with Exercise and Psychological Support

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Physical Activity;Prevention

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative  Cardiac conditioning is a therapeutic approach to induce endogenous protective adaptive responses in the heart for counteracting myocardial loss and dysfunction to prevent cardiac mortality and morbidity. This project explores the role and mechanisms of the exercise-driven heart rate acceleration pattern on cardiac conditioning and the clinical utility of a novel cardiac pacing method to improve cardiac resistance to injury and improve outcomes in patients with cardiomyopathies.

PI_NAMEs: HODGSON-ZINGMAN, DENICE  (contact);ZINGMAN, LEONID

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Acceleration;adrenergic stress;Adult;Adverse effects;Age;Automobile Driving;Back;Biochemical;Cardiac;cardiac pacing;Cardiac rehabilitation;Cardiomyopathies;cardioprotection;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Chronic;Clinical;clinically relevant;Complement;conditioning;Coupled;CREB1 gene;Data;Deceleration;Devices;Disease;Dissociation;EFRAC;Elements;Etiology;Evaluation;Event;Exercise;exercise intolerance;Exercise Tolerance;falls;Functional disorder;functional status;Gene Expression Profile;Genetic;Genetic Transcription;Heart;Heart Atrium;Heart Diseases;Heart failure;Heart Injuries;Heart Rate;hemodynamics;Human;human subject;Impairment;Implant;improved;improved outcome;in vivo;Injury;insight;Intervention;Ischemia;Ischemic Preconditioning;Knockout Mice;Left Ventricular Dysfunction;Left Ventricular Ejection Fraction;Link;Lipids;Manuals;Medical;Metabolic;Methods;Mitochondria;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial;myocardial injury;Myocardial Ischemia;novel;novel strategies;Optic atrophy 1;Outcome;Pathway Analysis;Patients;Pattern;Persons;Phase II Clinical Trials;Physical activity;physical conditioning;pilot test;PPAR gamma;preservation;prevent;Prevention;Prevention approach;programs;Proteins;Protocols documentation;Publishing;Quality of life;Randomized;receptor;Recommendation;Refractory;Regulation;Resistance;response;Rest;Risk;Risk Reduction;Role;Safety;Signal Pathway;Stress;stress tolerance;Systolic heart failure;Testing;Therapeutic;treadmill;treadmill training;trend;United States National Institutes of Health;Up-Regulation;Walking

PROJECT_TITLE: A New Pacing Approach for Cardiac Conditioning and Enhanced Cardioprotection

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Wound Healing and Care

ORG_CITY: FARMINGTON

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: In the US, keloids most commonly occur in individuals with African ancestry, are less prevalent in other populations of color and more rare in Whites. Despite the severe physical, psychological and social impact of keloids and despite the unsatisfactory treatment success, this wound healing disorder has been understudied and contributes to racial disparity in research and health care. Keloid research is highly relevant to public health and is recognized as such by the NIH/NIAMS Strategic Plan for fiscal years 2020-2024.

PI_NAMEs: REICHENBERGER, ERNST J (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: 3-Dimensional;Affect;African ancestry;Animal Genetics;Animal Model;Apoptosis;autosome;Biological;Biological Assay;Candidate Disease Gene;causal variant;Cell Adhesion;Cell Communication;Cell Cycle;Cell Differentiation process;Cell Proliferation;Cell Survival;cell type;Cells;Cellular Morphology;Characteristics;Cicatrix;Coculture Techniques;cohort;Complex;Data;Dermal;Development;Disease;Epithelium;Ethnic Origin;Ethnic Population;exome sequencing;Family;Fibroblasts;Fibrosis;Future;gene discovery;Gene Expression;Gene Mutation;Genes;Genetic;Genetic Heterogeneity;genetic linkage analysis;genetic variant;Goals;Healthcare;Heritability;Histology;Human;human induced pluripotent stem cells;immunodeficiency;Impaired wound healing;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inherited;Keloid;keratinocyte;Knowledge;Lesion;Macrophage;Mesenchymal;migration;Molecular;mouse model;mutant;Mutation;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nature;Nigeria;Nigerian;NOD/SCID mouse;Noise;novel;Pain;paracrine;Paracrine Communication;Pathway interactions;Patients;people of color;Phenotype;Population;Predisposition;Prevalence;protein expression;Psychological Impact;Public Health;racial disparity;racial population;Recurrence;Research;response;Risk;Role;segregation;Signal Transduction;Skin;Social Impacts;stem cell model;Strategic Planning;success;Susceptibility Gene;therapeutic target;Tissues;transcriptome sequencing;Transplantation;Trauma;tumor;United States National Institutes of Health;Variant;Work;wound;wound closure;wound healing;Xenograft procedure

PROJECT_TITLE: Causative mechanisms for keloid formation

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Clinical Research;Facioscapulohumeral Muscular Dystrophy;Muscular Dystrophy;Orphan Drug;Patient Safety;Rare Diseases

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE: Facioscapulohumeral muscular dystrophy (FSHD) is a progressive hereditary disorder that affects ~4 per 100,000 of the world’s population and causes patients to have impaired ambulation, weakness, muscle wasting, and impaired physical function. We previously completed an open label safety and tolerability study of testosterone paired with recombinant human growth hormone (rHGH) in FSHD, where participants demonstrated marked improvements in strength, walking distance, symptomatic burden, and lean muscle mass. Through this one-year planning grant, we will conduct and complete all of the necessary activities in order to conduct a definitive, multicenter, double-blind, placebo-controlled, efficacy trial of this very promising therapeutic approach for patients with FSHD.

PI_NAMEs: HEATWOLE, CHAD RYDEL (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Adult;Affect;Age;Agreement;arm;associated symptom;Atrophic;Award;Body fat;burden of illness;Clinical;Clinical Research;clinical research site;Clinical Trials;cohort;Combined Modality Therapy;Communities;Contracts;Data;Disease Progression;Double-Blind Method;efficacy study;efficacy trial;experience;Facioscapulohumeral Muscular Dystrophy;functional decline;Funding;gain of function;Grant;Hereditary Disease;Impairment;improved;Infrastructure;Injections;Institutional Review Boards;Laboratories;lean body mass;Life;men;meter;Monitor;muscle form;Muscular Atrophy;Muscular Dystrophies;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;open label;Participant;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacy facility;Phase;phase 3 study;Physical Function;physical impairment;Placebo Control;placebo controlled study;placebo controlled trial;Placebos;Population;Prevalence;Process;Protocols documentation;r-hGH-M;Readiness;recruit;Research;Research Personnel;response;Safety;safety testing;Secure;Serious Adverse Event;Site;Standardization;Starfish;Statistical Data Interpretation;Testing;Testosterone;Testosterone Enanthate;Therapeutic;Thinness;Time;United States National Institutes of Health;Universities;Walking

PROJECT_TITLE: STARFISH PIER: Study of Testosterone and rHGH in FSHD: Planning Infrastructure Execution and Readiness


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lung

ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE: Invasive aspergillosis causes significant mortality in patients with weakened immune systems. We seek to identify the early host-pathogen interactions dictating the outcome of infection through cytosolic sensing of fungal patterns of pathogenesis via MDA5/MAVS. Full activation of these early innate immune defense pathways will provide optimized resistance against respiratory fungal pathogens, which can be used for the development of immune modulatory strategies aimed at improving outcomes in patients.

PI_NAMEs: OBAR, JOSHUA J (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adoptive Transfer;airway surface liquid;Alveolar Macrophages;Anti-Bacterial Agents;anti-fungal agents;Aspergillosis;Aspergillus fumigatus;Automobile Driving;bioinformatics pipeline;Cells;Clinical;Computer Models;conditional knockout;cytosolic receptor;Data;Defect;Development;Double-Stranded RNA;Early identification;Event;Fetal Liver;fluidity;follow-up;Funding;Fungal Spores;fungus;Genetic Polymorphism;Goals;Host resistance;Human;Immune;Immune response;Immune system;Immunity;Immunocompetent;Immunocompromised Host;immunomodulatory strategy;improved outcome;Individual;Infection;Inflammation;inflammatory milieu;Inflammatory Response;Interferons;Knockout Mice;Knowledge;Laboratories;Lung;Macrophage;Mediating;microbial;Molecular;Morbidity - disease rate;mortality;Mucosal Immunity;Mus;mutant;Mycoses;Mycotoxins;novel;Organelles;Outcome;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Pathway interactions;patient population;Patients;Pattern;Pattern recognition receptor;peroxisome;Phagocytosis;Play;Production;Program Development;programs;receptor;Research;Resistance;respiratory;respiratory challenge;response;Risk;RNA;Role;secondary metabolite;sensor;Sentinel;Signal Pathway;Signal Transduction;Source;surfactant;System;Technology;Testing;Tissues;Transforming Growth Factor beta;Transgenic Organisms;Viral;Virulence;Work

PROJECT_TITLE: Fungal spore sensing by MDA5 is necessary for antifungal immunity against Aspergillus fumigatus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-J (02)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: Princeton

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Narrative A major challenge in medicine is to better understand and treat human cancers. In this proposal, we aim to develop novel computational methods to analyze cancer genomes in order to help uncover alterations that play an important role in cancer development or that can elicit an anti-cancer immune response. Application of our approaches will not only advance our understanding of basic cancer biology but also improve prospects for personalized cancer treatments.

PI_NAMEs: SINGH, MONA  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: actionable mutation;Affect;Algorithms;Alleles;Amino Acid Sequence;anti-cancer;anti-tumor immune response;Basic Science;Benchmarking;Binding;Cancer Biology;cancer cell;cancer genome;cancer genomics;cancer health disparity;cancer immunotherapeutics;cancer therapy;Clinical;clinically actionable;Computer software;computerized tools;Computing Methodologies;Data;Data Collection;deep learning;deep sequencing;design;Development;Dimensions;Disparity;Drug Targeting;Equity;experience;Formulation;Gene Expression;Genes;Genetic;genetic variant;Genome;genomic data;Germ-Line Mutation;Goals;Growth;Human;Immune;Immune response;improved;Individual;Inequity;insight;Knowledge;Language;Link;Machine Learning;machine learning framework;machine learning model;Major Histocompatibility Complex;Malignant Neoplasms;Medical;Medicine;method development;Methods;Missense Mutation;Modeling;Molecular;Mutate;Mutation;neoantigen vaccine;neoantigens;new therapeutic target;next generation sequencing;novel;Oncogenes;open source;Pathway interactions;Peptide/MHC Complex;Peptides;Performance;personalized cancer therapy;Play;Population;Population Group;Population Heterogeneity;precision oncology;Process;Property;protein complex;Protein Fragment;protein function;Proteins;Recommendation;Recurrence;Role;Sampling;Site;software development;Somatic Mutation;success;Testing;tumor;Variant;Visualization;Work

PROJECT_TITLE: Computational methods to decipher somatic alterations in cancer genomes

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Serious Mental Illness

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Digital phenotyping methods have the potential to identify dynamic risk factors in psychopathology. In a 6- month longitudinal study, we will examine the additive and interactive effects of ecological momentary assessment (active digital phenotyping) and computational estimates of emotion derived from speech (passive digital phenotyping) to predict self-reported and clinician-rated mood symptoms in individuals with bipolar disorder. The resulting data will improve fine-grained and quantitative behavioral assessment tools that allow for personalized modeling of emotion and mood dynamics in the real-world.

PI_NAMEs: MCINNIS, MELVIN G (contact);PROVOST, EMILY KAPLAN MOWER

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Acute;Arousal;Assessment tool;Behavior assessment;Bipolar Disorder;Clinical;Collection;cost;Data;depressive symptoms;Development;Devices;digital data;digital phenotyping;Ecological momentary assessment;Emotional;Emotions;Enrollment;Environment;experience;Functional disorder;Future;Goals;Grain;Health system;improved;In Situ;Individual;Infrastructure;Interview;Lived experience;Location;Longitudinal Studies;machine learning algorithm;Manic;Measurement;Measures;Mental disorders;Methods;Modeling;Monitor;mood symptom;Moods;National Institute of Mental Health;Noise;Outcome;Participant;participant enrollment;patient privacy;Patient Self-Report;Pattern;Persons;Phenotype;predictive modeling;Probability;Process;Prospective, cohort study;Protocols documentation;Psychopathology;psychosocial;recruit;Research Personnel;Risk;Risk Factors;risk mitigation;Sampling;Self Assessment;Series;Severities;Signal Transduction;smartphone application;social factors;Speech;Symptoms;Technology;Testing;Time;tool;Work

PROJECT_TITLE: Detecting dynamic fluctuations in emotion, mood, and functioning: A digital phenotyping approach to clinical monitoring in bipolar disorder

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Endocrine Disruptors;Genetics;Hepatitis;Liver Disease

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE Endogenous and exogenous Aryl hydrocarbon Receptor (AhR) agonists, cinnabarinic acid and 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) exhibit mutually exclusive transcription regulation of target genes, stanniocalcin 2 and cyp1a1 respectively with distinct physiological consequences. Cinnabarinic acid induced AhR-regulated stanniocalcin 2 provides hepatoprotection against non-alcoholic fatty liver disease. The experiments outlined in this proposal will characterize cinnabarinic acid-specific AhR-mediated regulation of stanniocalcin 2 and investigate mechanism by which AhR-stanniocalcin 2 signaling protect against steatohepatitis, which may prove instrumental in developing therapeutic strategies targeting hepatic diseases.

PI_NAMEs: JOSHI, ADITYA D (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acids;Address;Affect;Affinity;Agonist;Architecture;ARNT gene;Aromatic Hydrocarbons;Aromatic Polycyclic Hydrocarbons;Aryl Hydrocarbon Receptor;attenuation;Award;Binding;Biology;Cell Nucleus;Chemicals;Cholesterol;Chromatin;conditional knockout;Coupled;CRISPR/Cas technology;CYP11A1 gene;Cytoprotection;Data;Deterioration;Development;Diet;Epigenetic Process;Exhibits;experimental study;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Fructose;Future;Gene Expression Regulation;Genes;Genetic Transcription;Goals;halogenation;Hepatic;Hepatocyte;hepatoprotective;in vitro Model;in vivo;Individual;Investigation;Knockout Mice;Knowledge;Laboratories;Ligand Binding;Ligands;lipid biosynthesis;lipid metabolism;lipidome;lipidomics;Liver;Liver diseases;LoxP-flanked allele;Mass Spectrum Analysis;Mediating;member;Metabolic;metabolic phenotype;Modeling;Modification;Monitor;mouse model;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;obesogenic;Pathology;Pathway interactions;peptide hormone;Physiological;Play;pollutant;promoter;Promoter Regions;Protein Family;Proteins;Publishing;Receptor Activation;recruit;Regulation;response;Response Elements;Role;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;single-minded protein;stanniocalcin 2;Steatohepatitis;Tertiary Protein Structure;Tetrachlorodibenzodioxin;Therapeutic;transcription factor;Transcriptional Regulation;transcriptomics;translational research program;Triglycerides;Tryptophan;Xenobiotic Metabolism;Xenobiotics

PROJECT_TITLE: Aryl hydrocarbon receptor-mediated differential gene regulation - Mechanism of stanniocalcin 2 mediated protection against NAFLD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (04)]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Over 450 million people suffer from type 2 diabetes, a disease which is defined by the failure of pancreatic β-cells. These studies will provide new insights into the mechanisms by which nutrient metabolism stimulates insulin secretion in β-cells via the metabolic enzyme pyruvate kinase, and identify how this key enzyme amplifies external cues from incretin hormones and paracrine signals from neighboring α-cells that act via G-protein coupled receptors. This work may lead to new therapeutic approaches to restore insulin secretion in patients with type 2 diabetes and related metabolic diseases.

PI_NAMEs: MERRINS, MATTHEW J. (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: A kinase anchoring protein;Acceleration;Adenylate Cyclase;Agonist;Alpha Cell;Amino Acids;Anti-diabetic Drugs;bariatric surgery;Beta Cell;Binding;Biosensor;Calcineurin;Cell membrane;Clinical;Compensation;Cues;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;detection of nutrient;Development;diabetic rat;Disease;Drug Targeting;Electric Capacitance;Endosomes;Enzymes;Exocytosis Induction;Failure;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gastric Inhibitory Polypeptide;Generations;GIPR gene;GLP-I receptor;Glucagon;glucagon-like peptide 1;Glucose;GTP-Binding Protein alpha Subunits, Gs;hormonal signals;Human;in vivo;incretin hormone;insight;Insulin;insulin secretion;islet;Kinetics;Knock-out;Knockout Mice;Knowledge;Metabolic;Metabolic Diseases;Metabolic stress;mimetics;Mitochondria;Modeling;Mus;nano;next generation;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Nutrient;nutrient metabolism;paracrine;Paracrine Communication;Patients;Persons;pharmacologic;Phosphoenolpyruvate;Play;Production;Protein Isoforms;Publishing;Pyruvate Kinase;Rattus;receptor;Receptor Signaling;recruit;Regulation;response;Role;scaffold;Signal Pathway;Signal Transduction;source localization;Structure of beta Cell of islet;Testing;Therapeutic;therapeutic target;voltage;Work

PROJECT_TITLE: Metabolic Functions of Pyruvate Kinase M2 in Pancreatic Beta-cells


NIH_SPENDING_CATS: Genetics;Kidney Disease;Nutrition

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The blood potassium concentration must be maintained within narrow limits for critical life functions, including regular heart rhythm, muscle contraction, proper nerve impulses, and hormone secretion. ROMK potassium channels in the kidney are critical in maintaining potassium balance. This project will illuminate the mechanisms by which ROMK channels are regulated in health and become dysregulated in disease and provide new insights to develop drugs that treat disorders of potassium balance.

PI_NAMEs: WELLING, PAUL A (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Address;Aldosterone;Blood;Cells;Cellular biology;Clathrin Adaptors;common treatment;Consumption;Data;density;Diet;Dietary Potassium;Disease;Disinhibition;Distal;Distal convoluted renal tubule structure;Elements;Endocytosis;Equilibrium;Excretory function;Familial disease;Funding;gain of function mutation;Genetic;Genetic Models;Genomics;Health;heart rhythm;Homeostasis;Hormone secretion;Human;human disease;hyperkalemia;Hyperplasia;Hypertrophy;Hypokalemia;Image;In Vitro;in vivo;innovation;insight;Intake;Intercalated Cell;interdisciplinary approach;jagged1 protein;KCNJ1 gene;Kidney;Knock-out;Knockout Mice;Length;Life;MAPK7 gene;mathematical model;Mathematics;Measurement;Mediating;Micropuncture;Molecular;Molecular Genetics;mouse genetics;mouse model;Muscle Contraction;Mutation;Nephrons;Nerve;new therapeutic target;notch protein;novel;patch clamp;Pathologic;Pathway interactions;Pharmaceutical Preparations;Phenotype;Phosphorylation;Phosphotransferases;physiologic model;Physiological;Physiology;Plasma;Potassium;Potassium Channel;Potassium Deficiency;preservation;programs;reconstitution;Regulation;response;Signal Pathway;Signal Transduction;simulation;SLC12A3 gene;Sodium;Surface;targeted treatment;Testing;Textbooks;Three-Dimensional Imaging;transcriptome sequencing;urinary;Visualization

PROJECT_TITLE: Molecular of ROMK Channel Function


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative We propose to study the impact of mucosal adjuvanted vaccination on the outcome of disease, host immune responses to and transmission events after experimental respiratory infection with influenza virus and SARS- CoV-2. Hereto we will use the guinea pig (influenza) and Syrian golden hamster (SARS-CoV-2), two established models for vaccination, infection and transmission studies with respiratory viruses. We will compare protection provided by mucosal adjuvanted vaccination to parenteral vaccination and will investigate the impact of induction of protective immune responses at mucosal sites on host immune responses to infection (hybrid immunity) and virus transmission between vaccinated infected animals and naïve receiver animals.

PI_NAMEs: SCHOTSAERT, MICHAEL  (contact);WONG, PAMELA TINMOI

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;Address;Adjuvant;Adverse effects;Affect;Agonist;Air;Animal Model;Animals;Antibodies;breakthrough infection;Caring;Cavia;Convalescence;Coronavirus;COVID-19 pandemic;COVID-19 vaccine;Disease;Disease Outcome;Environmental Risk Factor;Epidemic;Event;experience;flu transmission;guinea pig model;Hamsters;Hybrids;Immune;Immune response;Immunity;Infection;Infection prevention;Influenza;Influenza Hemagglutinin;influenza infection;influenza virus vaccine;influenzavirus;Integration Host Factors;Intramuscular;Licensing;Lower respiratory tract structure;Lung;Mediating;Mesocricetus auratus;Messenger RNA;Modeling;Monitor;mucosal site;mucosal vaccination;Mucous Membrane;Mus;nanoemulsion;Nasal turbinate bone structure;Nose;Outcome;pandemic disease;Pathology;Populations at Risk;pre-clinical;Pre-Clinical Model;prevent;Principal Investigator;Property;Recombinants;Regimen;respiratory infection virus;Respiratory System;Respiratory Tract Infections;respiratory virus;response;Route;Safety;SARS-CoV-2 B.1.351;SARS-CoV-2 spike protein;SARS-CoV-2 transmission;SARS-CoV-2 variant;Solid;standard of care;Surface;Testing;transmission process;Upper respiratory tract;Vaccinated;Vaccination;vaccination outcome;vaccination strategy;Vaccine Antigen;vaccine response;vaccine safety;vaccine strategy;Vaccinee;Vaccines;Variant;variants of concern;viral transmission;Virus;Virus Diseases;Virus Replication;Virus Shedding

PROJECT_TITLE: Impact of mucosal adjuvanted vaccines on virus transmission in preclinical animal models for SARS-CoV-2 and influenza virus infection

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative: Sinoatrial node dysfunction represents a significant clinical burden in the US and is the leading cause for surgical implantation of artificial pacemakers. This proposal seeks to define the underlying cellular interactions that maintain normal sinoatrial node function. Successful completion of these studies will uncover the homeostatic processes that support native cardiac pacemaking, identify how these processes become disrupted in disease, and provide critical insight for the design of next-generation of therapeutics for correcting human arrythmias.

PI_NAMEs: BRESSAN, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Adult;Aging;Artificial cardiac pacemaker;Behavior;Binding;Biological;Biological Models;Biomechanics;Biosensor;Cardiac;cardiac aging;cardiogenesis;Cell Physiology;cell type;Cells;cellular pathology;Characteristics;Clinical;cohort;Collection;Data;design;Development;Devices;Disease;Disease Progression;Drops;Encapsulated;Environment;Extracellular Matrix;Feedback;Functional disorder;Funding;gain of function;Generations;Genes;Genetic Transcription;Heart;Heart failure;hemodynamics;Homeostasis;Human;human model;implantation;in vivo;insight;interstitial;interstitial cell;Life;Ligands;Link;Measures;Mechanics;Mediating;Modeling;Molecular;Morphogenesis;Myocardial;Myocardial Contraction;Neurons;Nodal;nodal myocyte;novel;novel therapeutics;Operative Surgical Procedures;paracrine;Paracrine Communication;Pathologic;Pathway interactions;Patients;Pattern;Periodicity;Physiological;preservation;Prevalence;Process;Production;programs;Property;Regulation;Repression;response;Rest;rho;segregation;Sick Sinus Syndrome;Signal Transduction;Sinoatrial Node;Sinus;Structure;Sudden Death;Supporting Cell;Syndrome;System;Testing;Therapeutic;Tissue Engineering;Tissues;treatment strategy;viscoelasticity;Work

PROJECT_TITLE: Regulation of cardiac pacemaker cell cytoarchitecture

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Brain Disorders;Cancer;Cerebrovascular;Neurosciences;Radiation Oncology

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Cerebral cavernous malformations (CCMs) are vascular lesions in the central nervous system that cause debilitating neurological problems. CCMs are usually treated by surgical removal, which is invasive and risky. In this proposal, we are developing and testing an MR image-guided technology (i.e. focused ultrasound) for overcoming physical barriers to drug delivery to CCMs in an effort to better control their pathological progression.

PI_NAMEs: PRICE, RICHARD J. (contact);TVRDIK, PETR

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Acoustics;Acute;Affect;Anatomy;Angiogenesis Inhibitors;bevacizumab;Biological Products;Blood;Blood Vessels;blood-brain barrier function;Cavernous Malformation;CCM1 gene;Central Nervous System;cerebral capillary;cerebral cavernous malformations;Characteristics;Chronic;Classification;Clinic;clinical care;Clinical Trials;Clonal Expansion;Complex;Consensus;Contrast Media;CSF1R gene;Data;Deposition;design;Development;Disease;Drug Delivery Systems;Drug Exposure;Drug Targeting;Endothelial Cells;Endothelium;Epithelium;Excision;experience;Exposure to;Feedback;Focused Ultrasound;Focused Ultrasound Therapy;Foundations;FRAP1 gene;Gamma Knife Radiosurgery;Genes;Germ-Line Mutation;Gliosis;Guidelines;Headache;Hemorrhage;Herpes zoster disease;Histology;Human;human disease;Image;image guided;image-guided drug delivery;ImmunoPET;Infrastructure;irradiation;Lesion;Location;Magnetic Resonance Imaging;Maps;Measurement;Mediating;Mesenchymal;Methods;Microbubbles;Molecular Weight;Monitor;Morbidity - disease rate;mouse model;Mus;Mutation;Nature;neovasculature;neuroinflammation;Neurologic;Numbness;occludin;Oxidative Stress;Paralysed;Pathologic;patient subsets;Patients;Permeability;Petechiae;Pharmaceutical Preparations;Pharmacological Treatment;Phenotype;PIK3CG gene;Population;Positioning Attribute;Positron-Emission Tomography;Preclinical Testing;pressure;Prevention;Proteins;Protocols documentation;recruit;Recurrence;Reporting;Route;Safety;Seizures;side effect;Signal Transduction;small molecule;Somatic Mutation;Stroke;success;synergism;System;Technology;Testing;Therapeutic;Thrombospondin 1;Tight Junctions;Transgenic Mice;Transgenic Model;Translating;Vision;Wild Type Mouse

PROJECT_TITLE: MR Image-Guided Drug Delivery to Cerebral Cavernous Malformations with Focused Ultrasound

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Routine chest CT examinations contain prognostic information that is often underutilized for its value in primary prevention of atherosclerotic cardiovascular disease (ASCVD), leaving missed opportunities for incidental screening to predict future cardiovascular events, such as heart attack and stroke. Current risk assessment tools, such as Pooled Cohort Equations (PCE), are poor predictors of ASCVD due to data limitations, most notably the static nature of the data and lack of model complexity, resulting in misestimation in minority groups. A graph- based multimodal fusion model that integrates imaging and electronic medical record data is essential to addressing the data limitations of outdated tools and creating more sophisticated technology that supports opportunistic screening of a larger, more diverse population of patients as well as earlier prevention strategies and therapeutics.

PI_NAMEs: GICHOYA, JUDY ;PATEL, BHAVIK NATVAR (contact)

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: Address;Adipose tissue;Adult;Algorithms;American;American Heart Association;Assessment tool;Atherosclerosis;Biological Markers;Black race;Body Composition;Body mass index;Calcium;Cardiology;cardiovascular disorder risk;Cardiovascular system;Categories;Cause of Death;Cessation of life;Chest;chest computed tomography;Clinic;Clinical;Clinical Data;clinical practice;cohort;college;Computerized Medical Record;Coronary;coronary artery calcium;Data;Data Element;Dedications;deep learning;deep learning model;demographics;Dependence;design;Equation;Ethnic Origin;Event;experience;experimental study;falls;Future;Gender;Goals;Graph;Health system;Image;imaging biomarker;imaging Segmentation;Individual;insurance plan;Manuals;Methods;middle age;Minority Groups;minority patient;Modeling;Morbidity - disease rate;mortality;multidisciplinary;multimodal fusion;multimodality;muscle form;Myocardial Infarction;Myocardial Ischemia;Nature;novel;Obesity;patient population;patient screening;Patients;Performance;Population;Population Heterogeneity;predictive tools;Prevention;Prevention strategy;Preventive;preventive intervention;Preventive therapy;Primary Prevention;prognostic;Prognostic Marker;prognostic performance;Race;racial bias;radiologist;Recommendation;Reporting;Risk;Risk Assessment;Risk Estimate;risk prediction;risk prediction model;risk stratification;Scanning;Scientist;screening;Semantics;Site;Skeletal Muscle;Slice;social health determinants;Stroke;subcutaneous;Techniques;Technology;Therapeutic;Thoracic aorta;tool;Training;United States;Universities;Validation;Visceral;Work;X-Ray Computed Tomography

PROJECT_TITLE: Opportunistic Screening for ASCVD using a Multimodal Deep Learning Risk Prediction Model

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Clinical Research;Lung

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative When you inhale harmful bacteria or fungi, they can stimulate airway tuft cells found interspersed throughout the nasal cavity and sometimes in the lungs. Tuft cells activate antimicrobial and inflammatory responses that might be useful to pharmacologically target in diseases like chronic rhinosinusitis or asthma. The goal here is to determine how the receptors in these tuft cells are activated and regulate tuft cell function to understand how we can leverage them to treat airway diseases.

PI_NAMEs: LEE, ROBERT J. (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Acetylcholine;Acute;Affect;Afferent Neurons;Agonist;Air;Airway Disease;airway epithelium;airway surface liquid;Amino Acids;Anti-Bacterial Agents;anti-microbial peptide;antimicrobial;Apical;Asthma;Bacteria;Basal Cell;Biosensor;Brush Cell;Cell Physiology;Cell secretion;cell type;Cells;cellular microvillus;Characteristics;Cholinergic Receptors;chronic respiratory disease;chronic rhinosinusitis;Comparative Study;Complement;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Disease;Dominant-Negative Mutation;Environment;Epithelial Cells;Epithelium;fluorescence imaging;Frequencies;fungus;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic;Genetic Diseases;genetic inhibitor;Glucose;Goals;Human;Image;Immune;Immunity;in vivo;Infection;Inflammation;Inflammatory Response;Inhalation;inhibitor;Injury;Intestines;Investments;Ion Channel;Knowledge;Label;Learning;Liquid substance;Lung;MAP Kinase Gene;Membrane;Messenger RNA;Methods;monolayer;Mus;Nasal cavity;Nasal Epithelium;Nasal Polyps;new therapeutic target;Nose;novel;optical imaging;optogenetics;Parasites;Pathway interactions;Patients;pharmacologic;Pharmacology;Primary Ciliary Dyskinesias;Process;promoter;protein activation;Protein Kinase C;Proteins;Publishing;Pulmonary Inflammation;Purinergic P1 Receptors;receptor;receptor expression;Regulation;Research;Residual state;Respiratory Tract Infections;response;Sensory;Sensory Receptors;Signal Pathway;Signal Transduction;small hairpin RNA;Small Interfering RNA;Sorting;Source;Succinates;surgery material;sweet taste perception;Taste Buds;Taste Perception;Techniques;Testing;therapeutic target;Time;Trachea;TRPM5 gene;Visualization;voltage

PROJECT_TITLE: Intracellular signaling in airway solitary chemosensory (tuft) cells

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Our proposal uses well established implementation science theories, models, and frameworks to develop, implement, and evaluate Proyecto Tariki, a novel dengue prevention and control program. Tariki aims to address 50 years of previous dengue program failures by inclusion of: 1) a proven community mobilization strategy that includes a mobile/web-based application, 2) community led febrile surveillance with direct link to health systems to improve case management, and 3) pragmatic protocols for Ministries of Health to evaluate their vector control interventions. Project adoption, sustainability, and scale-up will reduce transmission risk and health burden of dengue.

PI_NAMEs: PAZ-SOLDAN, VALERIE ANDREA (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Address;Adoption;Aedes;authority;Behavior Therapy;Bilateral;Case Management;Case Study;Characteristics;Cities;Communicable Diseases;Communities;community engagement;community intervention;Computer software;Consensus;Consolidated Framework for Implementation Research;cost;cost outcomes;COVID-19;COVID-19 pandemic;Culicidae;Data;data exchange;data streams;Dengue;Dengue Infection;Dengue Virus;design;Disease;Disease Outbreaks;Disease Outcome;Disease Surveillance;Disease Vectors;disorder control;disorder prevention;Educational workshop;Effectiveness;Ensure;Entomology;Epidemiology;epidemiology study;Evaluation;experience;Failure;Fatigue;Feedback;Fever;Focus Groups;global health;Government;Government Programs;Health;Health Personnel;Health system;Healthcare;high risk;Home;Household;implementation framework;implementation science;improved;Incidence;infection risk;informant;Infrastructure;Interruption;Intervention;intervention cost;Interview;Knowledge;Larva;Latin America;Link;Measurable;Measures;Medical;member;Methods;Misinformation;model building;Modeling;Monitor;Mosquito Control;Neighborhoods;Nicaragua;novel;Outcome;Outcome Study;Paraguay;Peru;Politics;pragmatic implementation;pragmatic intervention;Prevention;Process;Program Effectiveness;programs;prospective;Protocols documentation;Provider;Public Health;Pupa;Quechua;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Research Design;Research Personnel;Resources;response;Risk;Risk Reduction;Safety;scale up;Series;seroconversion;social;Surveys;Suspensions;System;Testing;theories;Time;tool;Training;transmission process;Triage;Vaccines;vector;vector control;vector mosquito;viral transmission;web app;web platform

PROJECT_TITLE: Proyecto Tariki: Implementation Science for Community-Mobilized Risk Reduction of Dengue

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-W (02)]


ADMINISTERING_IC: DE

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome;Natural Products;Prevention

ORG_CITY: BERKELEY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Public Health Relevance Statement: The proposed research is relevant to public health because it unveils the identity, biosynthesis and physiological roles of natural products produced by human oral pathogens that are important for their survial in human bodies, or produced by oral probiotics that fight against competing pathogens. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to increasing understanding of chemical ecology and physiology of oral microbes, pathogenesis of oral infection and microbiome and their impacts on oral health and disease, and laying the foundation for advances in maintaining oral health and treating oral diseases.

PI_NAMEs: ZHANG, WENJUN  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acids;Address;Adhesions;Adopted;Anabolism;Analytical Chemistry;Antibiotics;antimicrobial;Bacteria;Bacterial Infections;bioactive natural products;Biochemistry;Bioinformatics;Biological;biological adaptation to stress;Biology;butyrolactone;Cell Aggregation;Characteristics;Chemical Structure;Chemicals;Chemistry;Clinical;Communication;Complement;Complex;Data;Dental caries;design;Development;early childhood;Ecology;Etiology;Family;fighting;fitness;Foundations;Gene Cluster;gene function;Genome;Genomics;Goals;Gram-Positive Bacteria;host colonization;host-microbe interactions;Human;Human body;human microbiota;Hybrids;immunoregulation;in silico;innovation;insight;interdisciplinary approach;Knowledge;Lactic acid;Mediating;Medical;Mentored Clinical Scientist Development Program;metabolic engineering;Metabolism;Microbe;microbial;Microbial Biofilms;Microbiology;Mission;Molecular;Molecular Biology;Mouth Diseases;Names;Natural product discovery;Natural Products;novel;novel therapeutics;Nutrient;Odontogenesis;Oral;oral bacteria;Oral cavity;Oral health;oral infection;oral microbial community;oral microbiome;oral pathogen;pathogen;Pathogenesis;Peptides;Phenotype;Physiological;Physiology;Play;polyketides;Population;prevent;Probiotics;Process;Production;prophylactic;Public Health;public health relevance;Regulation;Research;Role;secondary metabolite;Signal Transduction;Signaling Molecule;small molecule;Streptococcus mutans;Streptococcus pyogenes;Streptococcus salivarius;synergism;transcriptomics;United States National Institutes of Health;Virulence;Work

PROJECT_TITLE: Bioactive natural product discovery from human oral microbes

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Asthma;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Several studies have demonstrated that exposure to higher concentrations of particulate matter (PM) leads to worse lung function growth, but the effects of specific PM sources and composition on disease course and lung function growth among children with asthma are largely unknown. We will conduct a prospective cohort study of 300 multi-ethnic children, the Texas Home Assessment of Asthma and Lung Exposures (TexHALE) study to examine associations between: 1) lung function growth; 2) persistence of disease severity; and 3) biomarkers associated with airway remodeling and lung function decline with PM exposure (sources, composition, and concentrations). The proposed aims will greatly advance our current understanding of the natural history of asthma, which is critical for developing interventions that modify the trajectory of childhood asthma.

PI_NAMEs: MATSUI, ELIZABETH C. (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Adult;Air Pollution;airway remodeling;Area;Asthma;asthmatic;Biological Markers;Black race;Child;Childhood;Childhood Asthma;Cities;Coal;Communities;Data;Disease;Disparity;Environmental Risk Factor;ethnic disparity;ethnic identity;ethnic minority population;Ethnic Population;Exposure to;Genetic;Growth;Health;Home;improved;indexing;insight;Intervention;Latinx;Link;Liquid substance;Lung;Lung Diseases;lung health;Measures;multi-ethnic;Nasal Epithelium;Natural History;outcome disparities;Participant;Particulate Matter;Play;Population;Property;Prospective, cohort study;pulmonary function;pulmonary function decline;racial disparity;racial identity;racial minority population;Regulation;respiratory health;Risk;Risk Factors;Role;Severities;Severity of illness;Shapes;Source;Testing;Texas;Time;traffic-related air pollution;Work

PROJECT_TITLE: Childhood Asthma: Disease Course and Lung Function Trajectories and Air Pollution Exposure

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Genetics;Neurodegenerative;Neurosciences;Nutrition;Sleep Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative Disrupted circadian rhythms are often a hallmark of neurodegenerative and neurological diseases, including Alzheimer's and Parkinson's, and it is becoming apparent that mitochondrial metabolic function plays a role in this disruption. We propose to use the power of Drosophila genetics, behavior, and physiology to determine the molecular and cellular links between perturbed metabolism, altered circadian rhythms, and neurological dysfunction. Additionally, we will establish the mechanistic basis of the ketogenic diet's ability to improve circadian function in the context of mitochondrial disease.

PI_NAMEs: PALLADINO, MICHAEL JOHN (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Aftercare;Alleles;Alzheimer's Disease;Amino Acids;Arrhythmia;ATP sensitive potassium channel complex;Behavior;Behavioral;Bioenergetics;Biological Assay;Biological Models;Brain;cell growth regulation;circadian;circadian biology;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Citrate (si)-Synthase;Citric Acid Cycle;Diabetes Mellitus;Diet;Diet therapy;dietary;Disease;Disease Progression;Drosophila genus;egg;Electrophysiology (science);Energy Supply;Environment;Enzymes;Epilepsy;Exhibits;experimental study;Feedback;fly;Functional disorder;Future;Gene Expression;Genetic;Genetic Screening;Genetic Transcription;Glycolysis;Health;healthy aging;Human;Hypersomnias;improved;Inherited;Ion Channel;ketogenesis;ketogenic diet;ketogentic;Ketone Bodies;Ketones;knock-down;Lateral;Leigh Disease;life span;Link;lipid metabolism;Lipids;Longevity;Mediating;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Methodology;Methods;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;model organism;Modeling;Molecular;molecular clock;Molecular Probes;NADP;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;Neuroglia;Neurologic;Neurologic Dysfunctions;Neurologic Effect;Neurologic Symptoms;Neurons;neuropathology;Neurotransmitters;nodal myocyte;novel;novel therapeutics;Obesity;Organism;Oxidation-Reduction;Oxidative Phosphorylation;Parkinson Disease;patch clamp;Pattern;Periodicity;Physiology;Planet Earth;Play;Process;Property;Quality of life;Regulation;response;RNA Interference;RNA interference screen;Role;Seizures;sensor;Sleep;Sleep Fragmentations;Sleeplessness;Standardization;Symptoms;System;Testing;therapeutic target;Translations

PROJECT_TITLE: Mechanisms of Circadian Rhythm Modulation by Metabolic Disease and Dietary Therapy

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative Bronchopulmonary dysplasia (BPD) also known as chronic lung disease of prematurity affects 10-15,000 newborns each year in the US with those born < 1 kg weight having a much greater risk. Magnetic Resonance Imaging (MRI) can measure not only the structural integrity of lung parenchyma and tracheal airway but also novel functional defects in lung perfusion and ventilation. Novel MRI techniques will be used to identify the root causes of BPD in each infant and assign a patient specific severity score.

PI_NAMEs: DYKE, JONATHAN PAUL;KOVANLIKAYA, ARZU  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Achievement;Affect;Age;Airway Disease;Alveolar;Anatomy;Area;Biological Markers;Breathing;Bronchopulmonary Dysplasia;Cardiopulmonary;Caring;Cessation of life;Chronic;Clinic;Clinical;clinical care;Clinical Management;Complication;Contrast Media;Data;Defect;Diagnosis;Disease;Disease Outcome;disease phenotype;disorder subtype;Distal;Enrollment;Fibrosis;Functional disorder;Functional Magnetic Resonance Imaging;Future;Gadolinium;Goals;Growth;Hypercapnia;Hypoxemia;Image;imaging biomarker;Impairment;improved;Incubators;Individual;Infant;Inflammation;Inhalation;Injury;insight;Knowledge;Length;Length of Stay;Lung;Lung Diseases;lung imaging;lung volume;Magnetic Resonance Imaging;Maps;Measures;Mechanical ventilation;Morbidity - disease rate;MRI Scans;National Institute of Child Health and Human Development;Neonatal;Neonatal Intensive Care Units;Newborn Infant;novel;Outcome;Oxygen;Oxygen Therapy Care;Patients;Perfusion;Perinatal;personalized therapeutic;Pharmaceutical Preparations;Phase;Phenotype;Physiological;postnatal;predict clinical outcome;Pregnancy;Premature Birth;Premature Infant;premature lungs;prognostic;prospective;Pulmonary Hypertension;pulmonary vascular disorder;Quality of life;Radiation;radiological imaging;Research;Resolution;respiratory;respiratory imaging;Risk;risk stratification;Scanning;Secondary to;Sedation procedure;Severities;Severity of illness;Stratification;Structure;Structure of parenchyma of lung;Subgroup;System;targeted treatment;Techniques;Therapeutic Intervention;Time;tool;Trachea;Tracheobronchomalacia;Tracheostomy procedure;translational potential;Update;Vasodilator Agents;ventilation;Ventilator;Vulnerable Populations;Weight

PROJECT_TITLE: Physiologic phenotyping of chronic lung disease of prematurity using MRI

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Genetics;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences

PHR: Narrative Adaptive immune responses involve the differentiation of CD4+ T cells into subsets that have different effector or regulatory functions. Our new data identifies novel signaling networks that drive the regulatory T cell versus Th17 cell fate choices. Challenges remain in controlling T cell activation leading us to query cell-intrinsic mechanisms of T cell activation which could aid in engineering T cells for therapeutic purposes.

PI_NAMEs: HAWSE, WILLIAM FRANCIS (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Affect;Allografting;ATP phosphohydrolase;Autoimmune;Autoimmune Diseases;autoreactivity;Binding;Biochemical;Biological;Biology;CD4 Positive T Lymphocytes;Cell Line;Cell Physiology;Cells;Cellular biology;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Clinical;cost;cytokine;Data;Data Set;Disease;effector T cell;engineered T cells;Enzymes;Equilibrium;Event;Experimental Autoimmune Encephalomyelitis;fascinate;FDA approved;Future;gene network;Generations;Genetic;Genetic Transcription;Health;Human;Immune;Immunology;improved;Inflammation;Inflammatory;inflammatory milieu;Knowledge;Lipids;Maintenance;Malignant Neoplasms;Modeling;Molecular;neuroinflammation;novel;Pathogenicity;Pathology;Pathway interactions;Persons;Phenotype;Phosphatidylinositols;Phospholipids;phosphoproteomics;Phosphorylation;Phosphorylation Site;Phosphotransferases;Population;programs;Proteins;Public Health;Publications;Publishing;Regulatory T-Lymphocyte;response;Rheumatoid Arthritis;Self Tolerance;Severity of illness;Signal Transduction;Signaling Molecule;Signaling Protein;small molecule;small molecule inhibitor;SMARCA4 gene;Solid;STAT3 gene;System;T cell therapy;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;TF gene;Therapeutic;Tissues;transcription factor;Work

PROJECT_TITLE: Defining how phospholipid signaling networks control Th17 differentiation and effector function

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Services;Heart Disease;Hypertension;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Women with a history of adverse pregnancy outcomes (APOs) are at increased risk of future cardiovascular disease. The goal of this study is to design a tool to help clinicians identify which women with APOs are most likely to develop CVD and suggest how to help reduce their risk. We will achieve this by: 1) using data from two large, national, longitudinal cohorts as well as a cohort derived from electronic health records of women recently delivering in North Carolina to identify the most common pathways from APO to cardiovascular risk factors to cardiovascular events; 2) engaging clinical experts to design the decision support tool based on the pathways and predicted risks revealed by the statistical analyses; and 3) soliciting feedback from practicing clinicians who would use to tool to help women with a history of APOs to reduce their risk of future cardiovascular disease.

PI_NAMEs: PENCINA, MICHAEL J;RICH-EDWARDS, JANET W (contact)

PROGRAM_OFFICER_NAME: POOL, LINDSAY REGINA

PROJECT_TERMS: Address;Adverse event;adverse pregnancy outcome;Age;American;American Heart Association;Articulation;Behavioral;Body mass index;Cardiology;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Caring;Chronic;Classification;Clinical;clinical decision support;clinically relevant;cohort;Cohort Studies;college;Coronary Arteriosclerosis;Data;delivery complications;design;Development;Educational workshop;Electronic Health Record;Enrollment;Event;Exercise;Feedback;Focus Groups;follow-up;Future;Gestational Diabetes;Goals;Health system;Healthcare Systems;high risk;Hospitalization;hypercholesterolemia;Hypertension;implementation research;Individual;infant outcome;Internist;Knowledge;Longitudinal cohort;Machine Learning;machine learning prediction;maternal morbidity;Maternal Mortality;maternal risk;Mediation;medical specialties;Methods;Myocardial Infarction;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;Non-Insulin-Dependent Diabetes Mellitus;North Carolina;novel;Nurses' Health Study;outcome prediction;Pathway interactions;Patient Education;Patients;Performance;Phenotype;pilot test;Population;post pregnancy;Pre-Eclampsia;Predictive Factor;Pregnancy Complications;pregnancy hypertension;Premature Birth;Prevention;Prevention education;prevention practice;Prevention strategy;Principal Investigator;Recommendation;Recording of previous events;Retrospective cohort;Risk;Risk Factors;risk prediction;screening;Small for Gestational Age Infant;Statistical Data Interpretation;Stroke;support tools;Surveys;Testing;Time;tool;Universities;Validation;Woman;women's prevention;Work

PROJECT_TITLE: Leveraging machine learning for cardiovascular disease risk prediction and prevention in women with a history of adverse pregnancy outcomes


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Recovery Support Services;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Telehealth

ORG_NAME: FRIENDS RESEARCH INSTITUTE, INC.

PHR: PROJECT NARRATIVE Black and Latinx people who use opioids (PWUO) bear a disproportionate burden of opioid-related overdose deaths. This proposal aims to adapt an evidence-supported Cultural Structural Humility (CSH) training to interactive video modules for peer recovery coaches (PRCs) that goes beyond a social determinants of health (SDH) framework to also include stigma reduction, health habitus, and patient navigation, and refine an artificial intelligence (AI)-driven texting tool to reinforce core CSH principles. The pilot RCT involves PRC completion of interactive video modules to facilitate telephone-based care coordination combined with AI- driven CSH-enhanced texting to deliver social services information addressing SDH to enhance receipt of buprenorphine among emergency department-recruited Black and Latinx PWUO.

PI_NAMEs: LEKAS, HELEN-MARIA ;LEWIS, CRYSTAL FULLER;TOFIGHI, BABAK  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: access disparities;Accident and Emergency department;Address;Administrator;arm;Artificial Intelligence;automated text message;barrier to care;Black Populations;Black race;Buprenorphine;buprenorphine treatment;care coordination;Clinical;Code;community partnership;cost;Data;efficacy trial;Enrollment;Equity;experience;Feedback;Funding;Harm Reduction;Health;Health system;Healthcare;Hospitals;Housing;housing instability;improved;Information Services;innovation;Institutional Racism;intervention effect;Intervention Studies;Latinx;Latinx population;Libraries;Measures;Medical;medical schools;medication for opioid use disorder;Mental Health;Methods;mHealth;Modeling;Motivation;multi-component intervention;multimodality;National Institute of Drug Abuse;Natural Language Processing;open source;opioid mortality;opioid overdose;opioid user;Outcome;overdose death;overdose prevention;Pamphlets;Participant;Patient Education;patient navigation;Patients;peer recovery;peer support;Positioning Attribute;post intervention;Prevention strategy;Provider;Public Health;Quality of life;racial disparity;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reaction Time;Recovery Support;recruit;Research;response;scale up;Self Management;service coordination;Service delivery model;Services;skills;social health determinants;social stigma;Social support;Social Work;socioeconomics;Structure;Surveys;Technology;Telemedicine;telephone based;Testing;Text Messaging;theories;therapy development;Time;tool;Training;treatment arm;treatment as usual;treatment duration;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;usability;user centered design;video module;Work

PROJECT_TITLE: Addressing racial disparities in opioid overdose deaths using an open source peer recovery coach training and multimodal mobile health platform


ORG_CITY: OMAHA

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Our previous studies have found decreased acetylcholine receptor currents and cell excitability in cardiac vagal neurons are associated with cardiac vagal dysfunction, which contributes to the high mortality in patients with type 2 diabetes mellitus. This proposal will focus on the potential mechanisms responsible for cardiac vagal neuronal dysfunction in T2DM. The significance of this project is to provide potential strategies to improve cardiac vagal function and to reduce mortality in patients with T2DM.

PI_NAMEs: LI, YU-LONG  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acetylcholine;Adipose tissue;Adrenergic Receptor;Animals;Arrhythmia;Attenuated;Autonomic Dysfunction;Axon;Baroreflex;Cardiac;Cardiovascular Physiology;Cardiovascular system;catalase;Cells;Cholinergic Receptors;Cysteine;Data;design;Diabetes Mellitus;diabetic patient;Dose;Efferent Neurons;Enzymes;Functional disorder;Ganglia;Genetic;Heart Rate;heart rate variability;High Fat Diet;Hydrogen Peroxide;Impairment;improved;In Vitro;in vivo;knock-down;Leptin;leptin receptor;Leptin resistance;Malignant - descriptor;Measures;Membrane;Mitochondria;Molecular;mortality;Nerve;neural;Neuronal Dysfunction;Neurons;Neurotransmitters;Nicotinic Receptors;Non-Insulin-Dependent Diabetes Mellitus;Norepinephrine;overexpression;Oxidative Stress;Patients;Peripheral;Pharmacologic Substance;Predisposition;Production;protein expression;Rattus;Signal Pathway;Signal Transduction;Streptozocin;sudden cardiac death;Testing;Therapeutic;therapeutic target;Transfection;UCP2 protein

PROJECT_TITLE: Potential mechanism underlying parasympathetic neuronal dysfunction in diabetes

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]