NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative: Aging-related cognitive decline is a significant concern amongst the elderly, and disruptions in memory can drastically reduce independence and quality of life. This study aims to further our understanding of the mechanisms that underlie learning by studying the dynamics of plasticity signals and how those might change in the context of aging. This knowledge could then inform the development new therapies for improving memory deficits, which has the potential to significantly improve the quality of life for a large portion of the aging population.

PI_NAMEs: TILDEN, ELIZABETH  (contact)

PROJECT_TERMS: Acute;Address;Adenylate Cyclase;Adult;Affect;age related;Aging;aging population;aging related;Animal Behavior;Animals;Behavior;Behavioral;Biological Assay;Cell Physiology;Cells;cognitive change;Cognitive deficits;Complex;Custom;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Development;Elderly;Electroencephalography;Electromyography;Electrophysiology (science);extracellular;Fluorescence;Frequencies;hallmarks of aging;hippocampal pyramidal neuron;Hippocampus;Hour;Impaired cognition;Impairment;improved;Knowledge;Learning;Measurement;Memory;memory consolidation;Memory impairment;Methodology;Methods;Molecular;Motivation;Mus;Nature;Neurons;novel;novel therapeutics;old mice;Optical reporter;optical sensor;Optics;patch clamp;Pattern;Peptides;Perforation;Performance;pharmacologic;Photometry;Physiological;Play;Population;Precision therapeutics;Process;Property;protein activation;protein function;Protein Inhibition;Protein Kinase A Inhibitor;protein kinase inhibitor peptide;Quality of life;Role;Signal Transduction;Signaling Molecule;Sleep;Sleep Deprivation;Sleep disturbances;Sleep Wake Cycle;Slice;Synaptic plasticity;temporal measurement;Testing;Therapeutic;Time;tool;Work

PROJECT_TITLE: The role of wake-associated protein kinase A transients in intrinsic plasticity and learning through aging


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Biotechnology;Health Effects of Indoor Air Pollution;Lung

ORG_CITY: OMAHA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: Health relatedness: Refractory asthma manifests with persistent symptoms such as airway inflammation and airway hyperresponsiveness despite the use of existing therapies and poses a major healthcare challenge. Our studies will identify the molecular mechanisms underlying regulation of airway inflammation and airway hyperresponsiveness by p63RhoGEF and its small molecule inhibitor CXN-8, leading to increased understanding of pathogenesis and therapeutic resistance in asthma. CXN-8 may offer a novel multisystem treatment approach to address the overarching challenge of refractory asthma.

PI_NAMEs: TU, YAPING  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Acute;Address;Adrenal Cortex Hormones;Affinity;Agonist;airway hyperresponsiveness;airway inflammation;Animal Model;Asthma;asthma model;asthmatic;Attenuated;Binding;Bronchoconstrictor Agents;Bronchodilator Agents;Catalytic Domain;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell model;Cells;Clinical Management;cytokine;data integration;Disease susceptibility;Docking;Dose;effectiveness testing;Extrinsic asthma;Functional disorder;Goals;Health;Healthcare;Human;idiopathic pulmonary fibrosis;In Vitro;in vivo;Inhalation;inhibitor;Libraries;Lung;Mediating;Molecular;molecular modeling;mouse model;Mus;Muscle Contraction;Mutagenesis;mutant;neutrophil;novel;novel strategies;novel therapeutics;Oral;overexpression;particle;Pathogenesis;persistent symptom;Pharmaceutical Preparations;pharmacologic;Phenotype;Pirfenidone;Play;Pyroglyphidae;Refractory;Regulation;Relaxation;respiratory smooth muscle;RNA Interference;Role;side effect;Signal Pathway;Signal Transduction;small molecule inhibitor;Smooth Muscle Myocytes;Specificity;Spectrum Analysis;Steroids;structural determinants;Surface Plasmon Resonance;System;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;therapy resistant;Tissue Model

PROJECT_TITLE: A Novel Approach to Target Neutrophilic Airway Inflammation and Airway Hyperresponsiveness in Therapy-Resistant (Refractory) Asthma.

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Rare Diseases;Tuberculosis

ORG_CITY: IRVINE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE The inability to quickly and accurately diagnose tuberculosis (TB) in children and initiate treatment is a major contributor to the high mortality of childhood TB worldwide. This study will identify novel Mtb- and host-derived biomarkers, and determine the best biomarker panels (i.e., biosignatures) that can meet the World Health Organization-recommended diagnostic accuracy thresholds for a TB triage or diagnostic test. If successful, the results will the first step needed to make progress toward addressing the critical unmet need for non-sputum biomarker-based tests for childhood TB.

PI_NAMEs: CATTAMANCHI, ADITHYA  (contact);ERNST, JOEL D.

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: 5 year old;accurate diagnosis;Address;Africa South of the Sahara;bioinformatics pipeline;Biological;Biological Assay;Biological Markers;biomarker discovery;biomarker identification;biomarker panel;biomarker signature;biosignature;Blood;Blood Banks;Cause of Death;Child;Childhood;Clinical;clinical research site;clinically relevant;co-infection;cohort;Communicable Diseases;Consensus;cost;Data;Detection;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic tests;Disease;Enrollment;Evaluation;Failure;field study;Gambia;Gene Expression;Gene Targeting;Genetic Transcription;HIV;HIV Infections;HIV/TB;Human;Immunity;Immunoassay;In Vitro;in vitro Model;in vivo;in vivo Model;Investigation;ion mobility;Knock-out;Machine Learning;Macrophage;Mass Spectrum Analysis;Measurement;Measures;Methods;Modeling;mortality;mouse model;multiple omics;Mus;Mycobacterium tuberculosis;next generation;novel;pathogen;Pathogenesis;Pathway Analysis;Pathway interactions;Performance;Plasma;point of care;point-of-care diagnostics;Post-Translational Protein Processing;Prevalence;Probability;prospective;Prospective cohort;Proteins;Recommendation;Reference Standards;Resolution;ROC Curve;Role;Sampling;South Africa;Specificity;Sputum;success;Symptoms;targeted biomarker;Testing;transcriptomics;Translating;Translational Protein Modification;Translations;Triage;Tryptophan;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;Uganda;United States National Institutes of Health;Urine;Validation;validation studies;World Health Organization

PROJECT_TITLE: Childhood ‘Omics’ and Mycobacterium tuberculosis-derived BiOsignatures (COMBO) for TB diagnosis in high HIV prevalence settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-R(50)R]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE Viruses that infect bacteria – bacteriophages – are exceptionally numerous, and the largest structural family has deep and important connection with human herpesviruses, an important pathogen for which no effective long-term remedies are available. They have potential for use as antibiotics and in drug and vaccine development. Our study aims to understand the organization and functions of the virus proteins required for assembly and that incorporate the viral genome. This knowledge will form a framework for understanding the structure and assembly of this large virus family and will inform the development of therapeutic approaches.

PI_NAMEs: CONWAY, JAMES F. (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;adenovirus penton protein;Affect;Antibiotics;Architecture;Bacteria;Bacterial Infections;Bacteriophage lambda;Bacteriophages;Biochemical;Biology;Biotechnology;botulinum;Capsid;Capsid Proteins;Cholera;Coliphages;Complex;crosslink;Cryoelectron Microscopy;Data;density;Development;Digestion;Diphtheria;DNA;DNA Packaging;drug development;Drug resistance;ds-DNA;Elements;erythrogenic toxin;Evolution;experience;Family;Family member;Genes;Genetic;Genetic study;Genome;Geometry;Head;Health;Herpesviridae;Horizontal Gene Transfer;Human;human pathogen;insight;interest;Knowledge;Maps;Modeling;Molecular;Molecular Biology;Molecular Conformation;Multi-Drug Resistance;mutant;Mutation;Mutation Analysis;N-terminal;Organizational Models;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;Peptide Hydrolases;Pharmaceutical Preparations;Planets;Positioning Attribute;Process;protein folding;Proteins;Proteolysis;Regulation;Resolution;scaffold;Scarlet Fever;self assembly;Site;structural biology;Structure;synergism;Tail;Technology;Testing;Therapeutic;therapeutic development;tool;vaccine development;Vaccine Research;Vaccines;Viral Genome;Viral Proteins;virology;Virus;Virus Assembly;Work

PROJECT_TITLE: Structure and assembly of dsDNA tailed bacteriophages

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE The University of Massachusetts, Boston (UMass Boston) and Dana-Farber/Harvard Cancer Center (DF/HCC) Partnership is committed to further developing a shared rigorous and collaborative transdisciplinary cancer and disparities-related research program that is primed for “Bridging the Divides: Innovations to Address Gaps in Cancer Disparities Research, Education, Outreach and Infrastructure.” Sophisticated research projects are proposed across several areas of basic biomedical and population sciences that will employ evidence and methods to converge upon and impact cancer and cancer health disparities at multiple levels of analysis. These projects, together with state-of-the-art Outreach and Research Education Cores and creative Research Design and Analysis Core and Genomics Cores, will serve to build research capacity and infrastructure at UMass Boston, expand the cancer disparities platform and community outreach programs at DF/HCC; and make, at an elevated level, significant advances to the science of cancer control.

PI_NAMEs: ABEL, GREGORY ALAN (contact);VISWANATH, KASISOMAYAJULA

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Absenteeism;Address;Advanced Malignant Neoplasm;anti-cancer research;Area;Biology;Boston;Cancer Center;Cancer Control;cancer health disparity;Cancer health equity;Cancer Science;career;career development;Charge;Color;Communities;community engagement;Community Networks;community organizations;Community Outreach;Creativeness;Data;Data Set;Dedications;Discipline;Disparity;dissemination science;Education;education research;Ethnic Origin;experience;Experimental Designs;experimental study;Faculty;Foundations;Funding;Genomics;Goals;Government;Grant;Health Disparities Research;implementation science;Incidence;Infrastructure;innovation;Institution;Joints;Lasers;Leadership;Malignant Neoplasms;Massachusetts;member;Mentors;Methods;Modeling;Morbidity - disease rate;mortality;outreach;outreach program;Phase;Population;Population Group;Population Heterogeneity;Population Sciences;Postdoctoral Fellow;programs;Race;Research;research and development;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Science;socioeconomic disparity;Solid;Source;Students;Training;translational model;translational potential;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities

PROJECT_TITLE: 2/2 The University of Massachusetts, Boston - Dana-Farber/Harvard Cancer Center U54 Comprehensive Partnership for Cancer Disparities Research


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Sleep Research

ORG_CITY: SEATTLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Whether the moon can affect sleep has been a matter of high controversy for decades. Our published and preliminary data clearly show that sleep timing is synchronized with the lunar cycle, leading to large changes in sleep duration even in people living in highly urbanized communities. The main goal of this project it to elucidate the mechanisms by which the moon cycle regulates sleep by focusing on two key sleep regulators, the circadian and homeostatic processes of sleep regulation.

PI_NAMEs: DE LA IGLESIA, HORACIO O (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Address;Affect;Area;Argentina;awake;Body Temperature;circadian;circadian pacemaker;circadian regulation;Circadian Rhythms;Communities;Data;Disease;Electricity;Environment;Event;Evolution;Geography;Goals;Habitats;Health;Human;Hydrocortisone;Impairment;indigenous community;Individual;Industrialization;Laboratories;Laboratory Finding;Lead;Life;Light;light intensity;Measures;Melatonin;Moon;Moon Cycle;Moon Phases;older adult;Participant;Pattern;Perception;Persons;Phase;Plasma;Pollution;Polysomnography;Population;pressure;Process;Protocols documentation;Psyche structure;Publishing;Recording of previous events;Recovery;Regulation;Rural;rural area;Sleep;Sleep Deprivation;Sleep disturbances;sleep onset;sleep pattern;sleep regulation;sleep regulatory center;Societies;System;Testing;Time;university student;Urban Community;urban setting;Urbanization;Variant;Visit;Wakefulness;Work;young adult

PROJECT_TITLE: Regulation of Circadian Rhythms and Sleep by The Lunar Month

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: VISWANATH, KASISOMAYAJULA  (contact)

PROJECT_TERMS: Address;Administrator;Advisory Committees;Area;Basic Science;Boston;Budgets;Cancer Center;cancer health disparity;Cell Nucleus;Clinical Sciences;Collaborations;Colon;Color;Communication;community partners;Complex;Dedications;Development;Education;education research;Educational Activities;Electronic Mail;Ensure;equity, diversity, and inclusion;experience;Faculty;Foundations;Funding;Goals;Grant;Growth;Infrastructure;innovation;Institution;Institutional Review Boards;Joints;Lead;Leadership;Malignant Neoplasms;Massachusetts;meetings;member;Mentors;Mentorship;multidisciplinary;Newsletter;outreach;Participant;Population Sciences;Postdoctoral Fellow;programs;recruit;Research;Research Personnel;Research Project Grants;Resources;Role;Running;social media;Structure;success;symposium;synergism;Training;Universities;Update;web site

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Liver Disease;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Advances in synthetic biology will play a fundamental role in shaping the future of cancer diagnostics toward earlier and more specific detection of disease. This proposal seeks to develop a new class of protease- activatable biosensors that implement Boolean AND logic for early detection of colorectal cancer liver metastasis.

PI_NAMEs: KWONG, GABRIEL A (contact);QIU, PENG

PROGRAM_OFFICER_NAME: SORG, BRIAN S

PROJECT_TERMS: Amplifiers;antigen test;Bacteria;Bar Codes;Benchmarking;Biodistribution;Biological;Biological Markers;Biology;Biosensor;Blood;Blood Tests;Body Fluids;Cancer Biology;Cancer Diagnostics;Cancerous;candidate identification;Carcinoembryonic Antigen;Cells;Classification;clinically relevant;Colorectal Cancer;colorectal cancer screening;Complex;Coupled;Cyclic Peptides;Data;design;Detection;detection limit;Development;Diagnostic;differential expression;Disease;Drug Kinetics;early detection biomarkers;Early Diagnosis;engineered T cells;Enzymes;Excision;FDA approved;Fluorogenic Substrate;fluorophore;Future;Gene Expression;Genes;Genetic;Genetic Engineering;Genetic Transcription;Growth;Human;Hydrolysis;Image;immunogenicity;improved;In Situ;in vivo;Inbred BALB C Mice;iron oxide nanoparticle;Kinetics;Liver;Logic;Longitudinal Studies;LS174T colon cancer cell line;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;mathematical model;Metastatic Neoplasm to the Liver;microCT;Modeling;models and simulation;Molecular;Monitor;mouse model;Neoplasm Metastasis;neoplastic cell;Noise;Non-Invasive Detection;Patient-Focused Outcomes;Peptide Fragments;Peptide Hydrolases;Peptides;Performance;Play;pre-clinical;preclinical evaluation;Preclinical Testing;predictive modeling;Production;Proteins;radiological imaging;Recombinants;Reporter;Role;Safety;Sampling;Screening for cancer;sensor;Serum;Shapes;Signal Transduction;Site;Specificity;synthetic biology;systemic toxicity;T cell response;T cell therapy;Testing;Thermal Ablation Therapy;Tissues;tumor;Tumor Antigens;tumor specificity;Urine;Validation;validation studies;Xenograft Model;Xenograft procedure

PROJECT_TITLE: AND-gated Synthetic Biomarkers for Early Detection of Liver Metastasis


PROJECT_TITLE: Planning and Evaluation Core


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW YORK

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Nuclear pore complexes (NPCs) selectively transport material into and out of the cell’s nucleus and directly control gene expression. Despite detailed structural studies, we still do not know much about how NPCs work, therefore this project intends to understand how they mediate and control key elements of nuclear transport and regulate their associated DNA, and how defects in these processes might lead to many developmental, viral or oncogenic diseases. This knowledge will ultimately open the possibility of therapeutically controlling nuclear pore complexes to correct defects that result in these diseases.

PI_NAMEs: AITCHISON, JOHN D.;ROUT, MICHAEL P (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;Architecture;Binding;Cell Nucleus;Cell Physiology;Cells;Chromatin;chromatin remodeling;Communicable Diseases;Complex;Cytoplasm;Data;Defect;design;Development;developmental disease;Disease;DNA;Drug Targeting;Elements;Epigenetic Process;Freezing;Functional disorder;Gene Expression;Gene Silencing;Genes;Hand;Human;human disease;Knowledge;Lead;Light;macromolecular assembly;Malignant Neoplasms;Maps;Measures;Mechanics;Mediating;Membrane;messenger ribonucleoprotein;Messenger RNA;Modeling;Molecular;mutant;Mutation;Nature;Nervous System Disorder;Nuclear;Nuclear Pore Complex;nucleocytoplasmic transport;Nucleoplasm;Oncogenic;Phenotype;Positioning Attribute;Process;protein function;Protein Isoforms;Proteins;Side;Site-Directed Mutagenesis;Structure;Testing;Therapeutic;Time;Viral;Work;Yeasts

PROJECT_TITLE: Structure-Function Mapping of the Nuclear Pore Complex-Renewal

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BURNS WHITE, KAREN ANN (contact)

PROJECT_TERMS: Address;American;Area;behavioral and social science;Behavioral Sciences;Black Populations;Boston;Cancer Center;cancer health disparity;career;career development;Color;Communication;Communities;COVID-19 pandemic;Dana-Farber Cancer Institute;design;Development;Disabled Persons;Discipline;Discipline of Nursing;Disparity;Doctor of Philosophy;Education;education research;Educational Status;Enrollment;Ethnic Population;evidence base;experience;Faculty;Fellowship;Fostering;Genomics;Graduate Degree;graduate school;graduate student;Grant;Group Affiliation;Growth;Health;health communication;Health Disparities Research;health disparity;Healthcare;improved;Individual;Infrastructure;innovation;Institutional Racism;interest;Intervention;Investments;Knowledge;Latinx;Low Income Population;Malignant Neoplasms;Manuscripts;Massachusetts;Mentors;Methods;multidisciplinary;Native Americans;NCI Center for Cancer Research;outreach;Peer Review;personalized cancer therapy;Phase;physical science;Population;Population Heterogeneity;Postbaccalaureate;Postdoctoral Fellow;Preparation;Process;Productivity;programs;Publications;racial population;Research;research and development;Research Design;Research Personnel;Research Project Grants;research study;Science;Science Enrichment;Scientific Advances and Accomplishments;Scientist;skills;Students;success;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Work

PROJECT_TITLE: Research Education Core


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Lung;Lung Cancer;Mental Health;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Many patients continue to smoke after cancer diagnosis, which reduces their survival. By studying social networks and affective states in the context of smoking behaviors, we will develop network-based smoking cessation interventions to protect cancer patients, their families and friends from negative impact of smoking.

PI_NAMEs: POGHOSYAN, HERMINE  (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Adult;Affect;Affective;Anxiety;Attention;Behavior;behavior influence;Cancer Center;cancer diagnosis;Cancer Patient;cancer recurrence;cancer type;Caring;Cessation of life;Chronic;Clinical;Complex;Dana-Farber Cancer Institute;Data;design;Diagnosis;Disease;Emotional;emotional distress;emotional shock;Emotions;Ensure;experience;Family;Family member;Feeling;Friends;Friendships;Fright;Health;HIV;Human;improved;Individual;individual patient;innovation;Interview;Investigation;Knowledge;longitudinal design;longitudinal, prospective study;maladaptive behavior;Malignant Neoplasms;member;Mental Depression;Methods;negative affect;Network-based;Newly Diagnosed;Nicotine Dependence;non-smoker;novel;Obesity;Outcome;Patients;Persons;prospective;Quality of life;Reaction;recruit;Relapse;Research;Risk;Science;sex;Smoke;Smoker;Smoking;Smoking Behavior;smoking cessation;Smoking Cessation Intervention;Smoking History;Smoking Status;social;social contact;Social Network;Structure;System;Testing;Time;Tobacco;Tobacco use;Tobacco-Related Carcinoma;Treatment Effectiveness;United States

PROJECT_TITLE: Longitudinal mixed method investigation of social networks and affective states as determinants of smoking behavior among cancer patient

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Prevention;Psychosis;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative People with psychotic disorders are excluded from most suicide-focused clinical trials despite incredibly high rates of completed suicide, and interventions that have been tested for this population have shown limited impact on suicide. Emotion dysregulation is a significant suicidogenic factor that is understudied in people with psychotic disorders. We propose to implement and evaluate an intervention targeting emotion dysregulation in people with psychotic disorders while employing rigorous statistical modeling and measurement techniques including Ecological Momentary Assessment, which will support future advanced research on suicide and suicide prevention for this high-risk group.

PI_NAMEs: PHALEN, PETER LEE (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: acceptability and feasibility;Accounting;Address;Aftercare;Area;Behavior;Cause of Death;Clinical Research;Clinical Trials;clinically relevant;completed suicide;Complex;Data;Data Collection;design;Dialectical behavior therapy;Disease;Ecological momentary assessment;emotion dysregulation;emotion regulation;Emotional;Emotions;Environment;Exclusion;experience;Failure;Feeling suicidal;follow-up;Future;Goals;health service use;Health Services Research;high risk population;improved;Institution;Intervention;intervention effect;Interview;Investigational Therapies;Knowledge;Laboratories;Link;Maryland;Measurement;Measures;medical specialties;Mental Health Services;Mentorship;Methodology;Methods;Modeling;Modification;multimodality;National Institute of Mental Health;neglect;Outcome;Outpatients;Participant;patient population;Patient Self-Report;Patients;Persons;Pilot Projects;Population;Population Intervention;Procedures;Psychoses;psychosis risk;psychosocial;psychotic;Psychotic Disorders;Qualitative Methods;Randomized, Controlled Trials;recruit;reducing suicide;Reproducibility;Research;Research Personnel;Research Project Grants;Research Proposals;response;Risk Reduction;Sampling;satisfaction;Science;severe mental illness;showing emotion;skills;skills training;Statistical Methods;Statistical Models;Structure;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide prevention;Techniques;temporal measurement;Testing;Training;treatment as usual;Universities;Work;World Health Organization

PROJECT_TITLE: Targeting Emotion Dysregulation to Reduce Suicide in People with Psychosis

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Lung;Lung Cancer;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking;Vaccine Related

PI_NAMEs: RAMANADHAN, SHOBA  (contact)

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent and Young Adult;adolescent health;Age;Alcohol consumption;anti-cancer research;Behavior;Black race;Boston;Cancer Center;Cancer Control;Cancer Control Research;cancer health disparity;cancer prevention;Cancer Prevention Intervention;cancer risk;career;Collaborations;Communities;community advisory board;community collaboration;community engaged research;community engagement;Community of Practice;community organizations;community partners;community-centered;Consultations;Dana-Farber Cancer Institute;Data;Development;Early Intervention;education research;emerging adulthood;Equity;ethnic minority;ethnic minority population;Evidence based intervention;experience;Goals;Health;health care availability;health care service;Health Promotion;healthy weight;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;implementation science;Inequity;Infrastructure;innovation;Institution;Internships;Intervention;Latino;Link;Literature;Low income;Low Income Population;Malignant Neoplasms;Massachusetts;Methods;Minority Groups;Modeling;next generation;outreach;Persons;Population;prevent;Prevention strategy;programs;racial minority;racial minority population;Research;Research Design;Research Methodology;Research Project Grants;Science;Services;Shapes;structural determinants;Students;theories;Tobacco use;Training;underrepresented minority student;underserved community;Universities;Work;Youth

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Precision Medicine;Women's Health Research

ORG_DEPT: SURGERY

ORG_STATE: MO

PHR: Project Narrative The goals of this project are to understand the immune bone marrow environment and disseminated tumor cells interactions which lead to metastases in triple negative breast cancer (TNBC) as well as develop biomarkers for therapy selection. We will accomplish this by 1: evaluating the ability of an 8-gene DTC gene panel to predict distant disease development in TNBC patients enrolled in a therapeutic trial of carboplatin/paclitaxel/nivolumab with or without cabiralizumab; Aim 2: understanding the extent of intra- and inter-patient molecular heterogeneity of BM DTCs in TNBC patients treated with conventional chemotherapy and ICI therapy and Aim 3: Correlating alterations in specific T cell and conventional dendritic cells (cDCs) populations in the BM with the presence of DTCs, and to determine the impact of conventional and ICI therapy.

PI_NAMEs: AFT, REBECCA L. (contact);DENARDO, DAVID G;WATSON, MARK A.

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Affect;antagonist;biobank;Biological;Biological Assay;Biological Markers;biomarker development;biomarker panel;Bone Marrow;Breast Cancer Patient;Breast Cancer therapy;Carboplatin;Cell Communication;Cells;checkpoint therapy;chemotherapy;Classification;Clinical;cohort;combinatorial;cytotoxic;Cytotoxic Chemotherapy;Data;Dendritic Cells;Detection;Development;Diagnosis;diagnostic assay;diagnostic tool;digital;Disease;Disease Resistance;Distant;Environment;Funding;Gene Expression;Gene Expression Profile;Gene Expression Profiling;gene panel;Genes;Goals;Heterogeneity;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immunologic Markers;Immunotherapy;improved;In complete remission;Individual;insight;Institution;Intervention;Macrophage Colony-Stimulating Factor Receptor;Malignant Bone Marrow Neoplasm;Malignant Breast Neoplasm;metastatic process;Methods;Molecular;molecular phenotype;Molecular Profiling;mortality;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Newly Diagnosed;Nivolumab;novel;novel therapeutic intervention;Paclitaxel;participant enrollment;Pathologic;Pathway interactions;Patient Participation;Patients;Phase;phase II trial;Phenotype;Population;prevent;Primary Neoplasm;prognostic;prospective;Randomized;Recurrence;Recurrent disease;Relapse;Residual Neoplasm;Residual state;response;Risk;risk stratification;Selection for Treatments;single cell sequencing;Specimen;standard of care;synergism;T-Lymphocyte;targeted treatment;Testing;Therapeutic Intervention;Therapeutic Trials;therapy resistant;triple-negative invasive breast carcinoma;tumor;tumor-immune system interactions;Tumor-infiltrating immune cells;Validation

PROJECT_TITLE: Synergized Immune and Tumor Cell Bone Marrow Biomarkers to Predict Recurrence in Triple Negative Breast Cancer

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Chronic Pain;Diabetes;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pain Research;Pediatric;Peripheral Neuropathy

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: RELEVANCE TO PUBLIC HEALTH Type 1 diabetes (T1D) is often accompanied by other autoimmune disorders. The goal of this proposal is to gain a clearer understanding of the spatial, temporal, cellular, and genetic contributions to T1D-associated autoimmune neuritis development. Gaining a better understanding of each of these contributory factors will provide a means to potentially pre-screen patients with T1D for a future risk of developing autoimmune nervous system disorders.

PI_NAMEs: RACINE, JEREMY J (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Acceleration;Address;Age;Antibodies;Antigens;Autoimmune;Autoimmune Diabetes;Autoimmune Diseases;Autoimmune Diseases of the Nervous System;Autoimmune Process;Autoimmunity;autoreactive T cell;autoreactivity;axon injury;B-Lymphocytes;Backcrossings;Biological Assay;Body System;C57BL/6 Mouse;CD4 Positive T Lymphocytes;Cells;chemokine;Chromosome Mapping;Chronic;Chronic Inflammatory Demyelinating Polyneuropathy;Clinical;Clone Cells;Consultations;cytokine;Data;Demyelinating Polyneuropathy;Demyelinations;Development;diabetes pathogenesis;Disease;Disease Progression;Disparate;exhaust;experimental study;first responder;Future;Genetic;genetic manipulation;Genetic Screening;genomic locus;Goals;Hindlimb;Histopathology;Immune response;Immunoglobulins;In Vitro;in vivo;Inbred NOD Mice;Infiltration;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;insulitis;Interferon Type II;islet;Knowledge;Leukocytes;Light;Lymphocyte;Mediating;Modeling;Modernization;Molecular;mouse model;multiple sclerosis patient;Mus;Mutation;Myelin;Nature;Nerve;nerve damage;Nerve Fibers;Nervous System;Neuritis;Neurons;Neuropathy;Non-Insulin-Dependent Diabetes Mellitus;novel;Organ;Pathogenicity;patient screening;Patients;Peptides;Peripheral Nerves;peripherin;pharmacologic;Phosphorylation;Population;Proliferating;Proteins;Public Health;Reaction;receptor;recruit;response;Risk;Role;sciatic nerve;sciatic nerve lesion;single-cell RNA sequencing;Site;Structure of beta Cell of islet;Susceptibility Gene;System;T cell infiltration;T cell receptor repertoire sequencing;T-Lymphocyte;T-Lymphocyte Subsets;temporal measurement;TNF gene;Transgenic Mice

PROJECT_TITLE: Cellular and Genetic Mechanisms of Autoimmune Diabetes Associated Neuritis

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative The goal of the MUSC Core Center for Clinical Research is to provide unique research resources to enable and enhance clinical and translational research designed to improve the health of individuals with rheumatic diseases, with a focus on scleroderma and lupus that have a disparate impact on women and minorities. A major emphasis is to communicate and collaborate with minority patient groups and communities to encourage input and participation in clinical research, dissemination and health promotion activities. These goals have been met with extensive use of the Cores and community engagement activities in the past four years.

PI_NAMEs: OATES, JAMES C (contact)

PROGRAM_OFFICER_NAME: GREEN PARKER, MELISSA C

PROJECT_TERMS: Address;African American population;ARHGEF5 gene;Award;Awareness;base;Big Data;biobank;Biological;Biometry;Biostatistical Methods;black patient;Black race;Chronology;Clinical;clinical care;clinical center;Clinical Data;clinical phenotype;Clinical Research;Collaborations;Communication;Communities;community engagement;Coupled;Data;Data Mart;Development;Diagnosis;Disease;Disease Progression;Education;Electronic Health Record;Electronics;Enrollment;Family;forging;Fostering;Foundations;Frequencies;Funding;gene environment interaction;General Population;Genes;Goals;Government Agencies;Health;health data;Health Disparities Research;Health Personnel;Health Professional;Health Promotion;Health Sciences;Hearing;high risk;improve minority health;improved;Individual;innovation;Institution;Knowledge;Leadership;Link;Lupus;Medical;meetings;Mentors;Methodology;Methods;Minority;minority engagement;minority health;Minority Participation;minority patient;Minority Recruitment;Mission;Morbidity - disease rate;mortality;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;Outcome;outcome disparities;Outcomes Research;Participant;Pathogenesis;patient portal;Patient Recruitments;Patients;Peer Review;Phenotype;Pilot Projects;Productivity;programs;Provider;Public Health;recruit;Reduce health disparities;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Resources;Rheumatism;Rheumatology;Risk;sample collection;Sampling;Scleroderma;Solid;South Carolina;success;synergism;Systemic Lupus Erythematosus;Systemic Scleroderma;tool;Translational Research;translational study;Trust;Universities;web platform;Woman

PROJECT_TITLE: Improving Minority Health in Rheumatic Disease (IMHeaRD)


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lupus;Prevention;Racial and Ethnic Minority Health Research;Scleroderma;Social Determinants of Health

PROJECT_TERMS: Administrative Supplement;Advisory Committees;Advocacy;Advocate;Appointment;Area;Awareness;black patient;Black race;Businesses;Clinical;clinical care;clinical center;Clinical Research;Collaborations;Collection;Communication;Communities;Conflict of Interest;Data;design;Diagnosis;Education;Effectiveness;Ensure;Ethnic Population;Evaluation;experience;Faculty;follow-up;Fostering;Foundations;Funding;Goals;Grant;Health;health care availability;health disparity;Health Professional;Human Resources;improve minority health;improved;Individual;Infrastructure;innovation;Institution;Investigation;Knowledge;Lead;Leadership;Lupus;Measures;Medical;meetings;Mentors;Methodology;minority investigator;Mission;Monitor;Morbidity - disease rate;mortality;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;operation;Outcome;Output;outreach;Patients;Performance;Pilot Projects;Prevention;Prevention strategy;Problem Solving;Productivity;programs;racial disparity;racial population;Reporting;Research;Research Activity;Research Institute;Research Personnel;Resource Sharing;Resources;Rheumatism;Risk;Sampling;Scientist;Scleroderma;SCTR gene;Services;Severities;shared database;skills;South Carolina;Systemic Lupus Erythematosus;Systemic Scleroderma;Time;tool;Translational Research;Travel;United States;Universities;Update;web site;women faculty


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Childhood Obesity;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: LONDON, WENDY BETH (contact)

PROJECT_TERMS: Absenteeism;Address;Adult;Advertisements;Advertising;Affect;American;analytical method;anti-cancer research;Area;Articulation;Basic Science;Benchmarking;Body mass index;Body measure procedure;Boston;Budgets;Cancer Center;cancer health disparity;Cancer Research Project;Child;Clinical Sciences;Collaborations;Communities;Consultations;County;Dana-Farber Cancer Institute;Data;data acquisition;Data Analyses;Data Collection;data management;design;Development;Discipline;Disease;Disparity;disparity reduction;District of Columbia;Early Intervention;Eating;econometrics;Education;education pathway;education research;Educational workshop;Ensure;Environment;ethnic minority;ethnic minority population;Ethnic Origin;Expenditure;experience;Experimental Designs;Exposure to;Faculty;fast food;Food;food environment;Funding;Generations;health equity;high risk;improved;Income;Individual;Infrastructure;innovation;Institution;Intervention;Knowledge;Letters;Link;Location;Logic;Low income;Low Income Population;Malignant Neoplasms;Massachusetts;Measurable;Measurement;Measures;Mediating;member;Mentorship;Methodology;Methods;minority communities;Minority Groups;minority investigator;minority trainee;Mission;Modeling;multiple data sources;novel;Obesity;obesity risk;Outcome;outreach;Pattern;Persons;Population;Population Analysis;Population Sciences;Postdoctoral Fellow;prevent;Process;Program Evaluation;programs;Qualifying;Race;racial minority;racial minority population;Recommendation;recruit;Research;Research Design;Research Methodology;Research Personnel;research study;Resource Sharing;Restaurants;Sales;Sampling;Sampling Biases;Selection Bias;Series;Services;sound;Statistical Methods;statistics;Students;success;synergism;Techniques;Testing;Training;training opportunity;Underrepresented Minority;Underserved Population;United States;United States National Institutes of Health;Universities;Weight Gain

PROJECT_TITLE: Shared Resource Core


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Data Science;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The goal of the interdisciplinary PASSCODE (Pancreatic Adenocarcinoma Stromal Reprograming ConSortium COordination, Data Management and Education) is to serve as an organizing “hub” for coordination, communication and collaboration within the Pancreatic Cancer Stromal Reprogramming Consortium (PSRC). The PASSCODE will provide administrative support, facilitate communication and collaboration, provide a centralized venue for data management, analysis and storage, and serve as a platform for consortium outreach and educational activities. Through its efforts, PASSCODE will significantly enhance the meaningful progress made by PSRC in improving survival outcomes for pancreatic cancer.

PI_NAMEs: LEE, J. JACK ;MAITRA, ANIRBAN  (contact)

PROGRAM_OFFICER_NAME: UJHAZY, PETER

PROJECT_TERMS: American;American Cancer Society;analytical tool;Area;Basic Science;biobank;Bioinformatics;Biological Assay;Biometry;Cancer Biology;Cancer Etiology;cancer genetics;Cataloging;Cells;Clinical;Clinical Trials Design;Cloud Computing;Collaborations;Communication;Communities;Computational Biology;computing resources;Cues;Data;Data Collection;Data Coordinating Center;data dissemination;data exchange;data harmonization;data management;Data Science;Data Storage and Retrieval;Dedications;Desmoplastic;Diagnosis;Disease;Disease Outcome;Ecosystem;Education;Education and Outreach;Educational Activities;Educational workshop;Elements;Ensure;Extracellular Matrix;Fibroblasts;Funding;Genetic;Goals;Group Meetings;Growth;Heterogeneity;Immune;improved;Infrastructure;innovation;Intranet;Lymphovascular;Malignant neoplasm of pancreas;Malignant Neoplasms;material transfer agreement;meetings;member;Mentorship;microbiome;minority trainee;Mission;Molecular;molecular pathology;mortality;multidisciplinary;multimodal data;neoplastic cell;Outcome;pancreas visualization;Pancreatic Adenocarcinoma;Pancreatic Ductal Adenocarcinoma;pancreatic tumorigenesis;Pathogenesis;Pathology;Patients;Persons;Policies;Procedures;programs;Reagent;Registries;Regulation;Research;Research Activity;Research Personnel;research study;response;Role;Secure;shared database;Site;Site Visit;social media;Solid;Specificity;Stromal Neoplasm;success;survival outcome;symposium;System;Therapeutic;Time;Tissues;Transfer Agreement;Translational Research;tumor;tumor immunology;tumor microenvironment;Tumor Promotion;Twitter;Underrepresented Minority;United States;United States National Institutes of Health;virtual;web site;working group


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Scleroderma;Social Determinants of Health

PI_NAMEs: NIETERT, PAUL J (contact)

PROJECT_TERMS: Address;Area;Bioinformatics;biomarker discovery;biomarker validation;Biometry;Biostatistical Methods;Candidate Disease Gene;clinical development;Clinical Investigator;Clinical Research;clinically relevant;Collaborations;Communities;Complex;Data;Data Analyses;data management;Database Management Systems;Databases;design;Development;Diagnostic tests;Disease;Disparity;Doctor of Philosophy;Education;Educational workshop;Ensure;Epidemiology;Faculty;Future;genome wide association study;Goals;improve minority health;Information Dissemination;innovation;Institution;interdisciplinary approach;Investigation;Journals;Leadership;lectures;Manuscripts;method development;Methodology;Methods;minority health;novel;Outcome;Pilot Projects;Play;predictive modeling;Preparation;Process;prognostic assays;programs;racial disparity;Recommendation;Registries;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;Resources;Respondent;Rheumatism;rheumatologist;Rheumatology;Role;Series;sound;Surveys;Systemic Lupus Erythematosus;Systemic Scleroderma;Techniques;tool;Translational Research;translational scientist;University resources


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lupus;Racial and Ethnic Minority Health Research;Rare Diseases;Scleroderma;Social Determinants of Health

PROJECT_TERMS: Acceleration;Achievement;Address;anti-cancer research;Area;ARHGEF5 gene;Autoimmunity;base;biobank;Biological;Biological Markers;Biological Specimen Banks;Black race;Budgets;cancer immunotherapy;Clinic;Clinical;clinical care;Clinical Research;Collaborations;Collection;Communities;community engagement;community partnership;Consultations;Data;Data Analyses;Data Mart;demographics;Electronic Health Record;Enrollment;Epigenetic Process;experience;Faculty;Family member;Fibrosis;flexibility;Foundations;Funding;Future;Genetic;Goals;Health;health disparity;Health Promotion;health record;Hormones;Human Resources;Immunology;improve minority health;improved;Industry Collaboration;Informatics;informatics infrastructure;Infrastructure;International;Knowledge;Laboratories;Link;lipidomics;Longitudinal cohort;Lupus;member;Methodology;Methods;microbiome;novel;outreach clinics;Pathway interactions;patient population;Patient Recruitments;Patients;Peripheral Blood Mononuclear Cell;Phenotype;phenotypic data;Pilot Projects;Population;Process;Productivity;Quality Control;recruit;remote consent;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;response;Rheumatism;Rheumatology;sample collection;Sampling;Scleroderma;Services;Site;skin biopsy;social determinants;Solid;Specimen;Surveys;Systemic Lupus Erythematosus;Systemic Scleroderma;Targeted Research;Text;Time;Translational Research;Translations;Visit;volunteer;Work


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Diabetes;Heart Disease;Nutrition;Women's Health Research

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Diabetes increases the occurrence and severity of heart disease and heart failure. This occurs because diabetes impairs heart metabolism and function. We are investigating whether increasing the ability of the heart to metabolize sugar prevents this diabetic heart disease and improves overall health.

PI_NAMEs: HUMPHRIES, KENNETH M (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: 6-Phosphofructo-2-kinase;adipocyte differentiation;Adipocytes;Adipose tissue;Adrenergic Agents;Adult;Affect;Bioenergetics;Biological Assay;blood glucose regulation;Cardiac;Cardiac Myocytes;cardioprotection;Cause of Death;Chronic;Defect;Diabetes Mellitus;diabetic;diabetic cardiomyopathy;Diet;dietary;Echocardiography;Energy Metabolism;enzyme activity;Enzymes;Estrogens;Face;fatty acid oxidation;Fatty Acids;feeding;Female;flexibility;Free Radicals;Functional disorder;functional improvement;Future;glucose metabolism;glucose tolerance;glucose uptake;Glycolysis;Goals;Health;Heart;Heart Diseases;Heart failure;heart function;heart metabolism;Heart Mitochondria;High Fat Diet;Hyperglycemia;Impairment;improved;insulin sensitivity;insulin signaling;Insulin-Dependent Diabetes Mellitus;Knockout Mice;Knowledge;Lipids;Measures;Mediating;Metabolic;metabolic profile;Metabolic syndrome;Metabolism;metabolomics;Mitochondria;mitochondrial dysfunction;Modeling;Mus;Muscle;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;Ovariectomy;oxidation;Oxidative Stress;Population;prevent;Production;Proteomics;Public Health;Pyruvate;pyruvate dehydrogenase;Pyruvate Metabolism Pathway;Radiolabeled;Regulation;Resistance;response;Role;Severities;skeletal tissue;Stress;sugar;Testing;Therapeutic;type I and type II diabetes;Work

PROJECT_TITLE: Increasing glycolysis in the diabetic heart is cardioprotective and improves glucose tolerance

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

PI_NAMEs: WAGLE, NIKHIL  (contact)

PROJECT_TERMS: Address;African American;African ancestry;Androgen Receptor;anti-cancer research;Bioinformatics;Biomedical Research;Biostatistical Methods;Boston;BRCA2 gene;Cancer Biology;Cancer Center;cancer health disparity;cancer initiation;cancer risk;CHD1 gene;Code;cost;Dana-Farber Cancer Institute;Data;Data Analyses;design;DNA Sequence;Education;education research;Educational workshop;experience;Fees;Frequencies;Genetic Transcription;Genomic approach;genomic data;Genomics;Goals;health disparity populations;Infrastructure;innovation;Institution;Instruction;instrumentation;Learning;Malignant neoplasm of prostate;Massachusetts;men;Minority-Serving Institution;Modeling;nano-string;novel;Outcome;outreach;personalized cancer therapy;Population;programs;Prostatic Neoplasms;Quantitative Reverse Transcriptase PCR;Receptor Signaling;Research;Research Design;Research Personnel;Resources;Risk;RNA;single cell sequencing;SNP genotyping;Structure;Students;Technology;therapy resistant;tool;Training;tumor progression;Underrepresented Populations;Underrepresented Students;Universities;Untranslated RNA

PROJECT_TITLE: Genomics Core


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Rural Health

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE The Dartmouth Regional Pediatric Clinical Trials Unit provides a regional home for the conduct of interventional clinical trials for children. This Unit will support education of clinician scientists, infrastructure for the conduct of local clinical trials, and participation in the national IDeA States Pediatric Clinical Trials Network.

PI_NAMEs: HARTMAN, TYLER ;PALUMBO, PAUL E. (contact)

PROGRAM_OFFICER_NAME: RAJU, TONSE N

PROJECT_TERMS: academic program;Advisory Committees;Area;biomedical data science;candidate identification;Catchment Area;Child;Childhood;clinical practice;Clinical Research;clinical translation;clinical trial implementation;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;Communities;Community Trial;design;Development;Disease;Education;Enrollment;Faculty;flexibility;Fostering;Funding;Home;Infrastructure;Institution;interest;Intervention;Leadership;Lebanon;Link;Medical center;medical schools;meetings;member;Mentors;Multi-Institutional Clinical Trial;Multicenter Studies;Multicenter Trials;New England;Pediatric Hospitals;Pediatric Research;Population;Pregnant Women;Process;programs;Protocols documentation;recruit;Research;Research Personnel;Resources;Rural;Rural Population;Scientist;senior faculty;Teacher Professional Development;Training;Underserved Population;Universities;vaping;Vermont;Youth

PROJECT_TITLE: ECHO IDeA States Pediatric Clinical Trials Network - 2


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: VILLIGEN PSI

ORG_COUNTRY: SWITZERLAND

ORG_FIPS: SZ

ORG_NAME: PAUL SCHERRER INSTITUT PSI

PHR: Project Narrative Imaging biological tissue such as brains at subcellular resolution is of fundamental importance for the understanding of biological processes. With iterative thinning multibeam transmission electron microscopy, the detailed cellular ultrastructure in very large tissue samples such as entire brains could be visualized. This will enable researchers and clinicians to visualize the biological organization and cellular interactions of entire organs at centimeter-scale down to cellular compartments at nanometer resolution.

PI_NAMEs: SCHAEFER, ANDREAS ;WANNER, ADRIAN ANDREAS (contact)

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;automated segmentation;Back;Biological;Biological Process;Brain;Collection;Development;Diamond;Electromagnetic Fields;Electron Microscope;Electron Microscopy;Electrons;Failure;Film;Hour;Human;Image;improved;Ions;Magnetism;Manuals;microscopic imaging;Microtomy;millimeter;Morphologic artifacts;Mus;nanometer resolution;neuronal circuitry;Neurons;Organ;Pyramidal Cells;reconstruction;Research Personnel;Resolution;Sampling;Scanning;Scanning Electron Microscopy;segmentation algorithm;Series;Silicon;Solid;Surface;Synapses;System;Techniques;Thick;Thinness;Tissue Sample;Tissues;Transmission Electron Microscopy;transmission process;Visualization;Yin

PROJECT_TITLE: BRAIN CONNECTS: Multi-Beam Transmission Electron Microscopy of Iteratively Milled Semi-Thick Tissue Sections


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PUBLIC HEALTH RELEVANCE: As a group, intellectual and developmental disabilities, including Down syndrome and autism spectrum disorder, have dramatic effects on affected people’s and their caregiver’s lives. Unfortunately, there remains a lack of understanding about what causes these disabilities and, critically, how to treat them with targeted therapies. The Vanderbilt Kennedy Center’s Intellectual and Developmental Disabilities Research Center serves as the hub for Vanderbilt’s research efforts focusing on improving the lives of people with intellectual and developmental disabilities by understanding the causes of these disorders and developing and testing therapies tailored to each individual’s precise needs.

PI_NAMEs: NEUL, JEFFREY L (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Academic Medical Centers;Acceleration;Affect;Antipsychotic Agents;autism spectrum disorder;Basic Science;Behavioral;behavioral phenotyping;Biomedical Research;Caregivers;Caring;Clinical Research;clinical translation;Clinical Trials;Communication;Communities;comorbidity;Computerized Medical Record;cost effective;Data;Data Science;Development;Developmental Disabilities;developmental disease;Diagnosis;disability;Disability research;Disease;disease model;Down's Syndrome;drug-induced weight gain;Education;Evaluation;experience;Faculty;Family;Foundations;Funding;Future;Genotype;Goals;Image;image processing;implementation science;improved;Individual;individualized medicine;individuals with autism spectrum disorder;Infrastructure;innovation;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Interdisciplinary Study;Intervention;large datasets;Leadership;lectures;life span;Machine Learning;Medical Records;meetings;Methods;Mission;Modeling;multidisciplinary;National Institute of Child Health and Human Development;Neurodevelopmental Disability;novel;Obesity;organizational structure;Outcome;Participant;personalized approach;personalized care;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacogenetics;Phase;Pilot Projects;Policy Research;population based;pragmatic trial;predictive modeling;Prevention;Problem behavior;programs;public health relevance;Publications;recruit;Research;Research Personnel;Research Project Grants;research study;Resources;Risk;Sampling;Schools;Series;Services;skills;success;targeted treatment;Techniques;Technology;Testing;Training;translational neuroscience;Translational Research;Translations;trial comparing;United States National Institutes of Health;Universities;Vision;Weight Gain;Work

PROJECT_TITLE: Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt


NIH_SPENDING_CATS: Brain Disorders;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PROJECT_TERMS: Academic Medical Centers;Administrative Efficiency;Advisory Committees;Affect;Area;autism spectrum disorder;Awareness;Basic Science;Behavioral;Binding;Caregivers;Clinical Research;Collaborations;college;Communication;Communication Methods;Communities;community advisory board;community engagement;Consult;cost effective;Diagnosis;disability;Disability research;Disease;dissemination science;Down's Syndrome;Education;educational atmosphere;Ensure;Environment;Event;Faculty;Faculty Recruitment;Family;Friends;Funding;Glues;Goals;Government;Grant;implementation science;improved;Individual;individualized medicine;Infrastructure;innovation;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Interdisciplinary Study;Intervention;Intervention Studies;Leadership;Learning;lectures;meetings;Methods;Mission;Modeling;multidisciplinary;National Institute of Child Health and Human Development;Neurosciences;next generation;operation;organizational structure;personalized care;Persons;Policies;Policy Maker;Prevention;Process;Productivity;public health relevance;recruit;Research;research and development;Research Institute;Research Personnel;Research Project Grants;Resources;satisfaction;Science;Scientist;Series;Services;Structure;Surveys;targeted treatment;Technology;Testing;therapy development;Thinking;Training;Translational Research;translational research program;Translations;Travel;Universities;uptake;Vision;Work

PROJECT_TITLE: Core A: Administrative Core


ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative The goal of this proposal is to elucidate how manipulation of PTH receptor interaction with beta-catenin can prevent cartilage lesions and increase cartilage repair via shifting the PTH receptor signaling toward its therapeutic pathway. Thus, the therapeutic strategies in the present proposal help overcome the limitation of current usage of PTH or PTHrP for the prevention and treatment of osteoarthritis.

PI_NAMEs: WANG, BIN  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Affinity;Amino Acids;Anabolic Agents;arm;articular cartilage;Award;beta catenin;Binding;Binding Proteins;Binding Sites;Biochemical;Cartilage;cartilage degradation;cartilage regeneration;cartilage repair;Catabolism;Cells;Chondrocytes;Clinical Trials;Complex;cost effective;Cyclic AMP;Data;Degenerative polyarthritis;Dependovirus;design;Development;Disease Progression;Doxycycline;enzyme activity;enzyme pathway;Event;Genetic Materials;Goals;GTP-Binding Protein alpha Subunits, Gs;Human;Hypertrophy;improved;in vivo;Injections;Joints;Knee joint;Lesion;Mediating;medication compliance;Mesenchymal;Modeling;molecular modeling;mouse model;Mus;NF-kappa B;novel;Outcome;Oxidative Stress;parathyroid hormone (1-34);Parathyroid Hormone Receptor;parathyroid hormone-related protein;particle;Pathogenesis;Pathogenicity;Pathway interactions;Peptides;Play;pre-clinical;prevent;Prevention;protective effect;Protein Inhibition;PTH gene;Publishing;Reactive Oxygen Species;receptor;Receptor Signaling;Regulation;response;Role;Satellite Viruses;Signal Pathway;Signal Transduction;Testing;Therapeutic;Therapeutic Effect;Toxic effect;transgene delivery;Traumatic Arthropathy;Tropism;WNT Signaling Pathway;Work

PROJECT_TITLE: Targeting the PTH1R Signaling Pathway for Osteoarthritis Therapy by a Novel Disruptor Peptide

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PI_NAMEs: MALOW, BETH A (contact)

PROJECT_TERMS: Acceleration;Address;Affect;aging population;Area;Asthma;autism spectrum disorder;Behavior assessment;behavioral phenotyping;Blood;Caregivers;Child;Clinical;Clinical Research;clinical translation;Clinical Trials;community engagement;Consent;Consultations;Data;Data Analyses;Data Science Core;design;disability;Disability research;Discipline;Disease;Down's Syndrome;driving force;Education;education research;Educational Intervention;Educational Materials;efficacy evaluation;electronic consent;electronic data;Electronic Health Record;Enrollment;Exclusion;Face;Family;Feedback;Future;Genetic Databases;Healthcare Systems;imaging modality;improved;Individual;individualized medicine;innovation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Intervention;Intervention Studies;Learning;life span;Maintenance;Medical;Medical Research;Methods;Modeling;neurophysiology;novel;novel strategies;Obesity;Outcome;Participant;Patients;Persons;Population;Population Study;Pragmatic clinical trial;pragmatic trial;Preparation;Prevalence;Protocols documentation;public health relevance;recruit;Registries;remote intervention;Research;Research Design;Research Personnel;Research Project Grants;research study;Resources;response;retention rate;Rural Population;Scanning;Schools;Services;Structure;System;targeted treatment;Technology;telehealth;Testing;tool;Training;Training and Education;Translating;translational neuroscience;Translational Research;translational study;vaccine trial;Work

PROJECT_TITLE: Core B: Clinical Translational Core


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Obesity;Pediatric;Precision Medicine;Prevention;Serious Mental Illness

PHR: PUBLIC HEALTH RELEVANCE: Behavioral problems in autism are often managed using antipsychotic drugs that can cause weight gain and obesity. In this work, we will try to identify clinical and genetic features that might indicate who is at increased risk for this weight gain, as well as compare how often the weight gain occurs depending on which drug is used. Understanding these things could help develop methods to better use these drugs, or identify ways to avoid use altogether.

PI_NAMEs: DAVIS, LEA K (contact)

PROJECT_TERMS: Address;Adult;Affect;Aggressive behavior;Ambulatory Care Facilities;Antipsychotic Agents;Anxiety;Area;aripiprazole;atypical antipsychotic;autism spectrum disorder;autistic children;Behavior;Behavior Therapy;Behavioral;biobank;Biological Markers;Cardiovascular system;Caregiver Burden;Caregivers;Caring;Child;Clinical;clinical care;Clinical Decision Support Systems;clinical predictors;clinical translation;clinically relevant;cohort;Communities;comorbidity;Computerized Medical Record;Data;Data Science Core;Databases;design;Development;Diabetes Mellitus;Disabling;Drug usage;efficacy evaluation;electronic consent;Electronic Health Record;Elements;Emergency department visit;Evaluation;Family;FDA approved;Genetic;genetic association;genetic information;genetic predictors;genetic risk factor;genome wide association study;Genotype;Health;High Prevalence;high risk;improved;Individual;individuals with autism spectrum disorder;innovation;innovative technologies;Institution;Intellectual and Developmental Disabilities Research Centers;interest;Intervention;Knowledge;Link;machine learning method;machine learning model;Measures;Mental Health;Metabolic syndrome;Methods;Modeling;neural network;Neurodevelopmental Disorder;Obesity;obesity development;Obsessive compulsive behavior;Older Population;Outcome;Outcome Measure;Parents;Participant;Performance;personalized care;Persons;Pharmaceutical Preparations;Pharmacogenetics;pharmacologic;Pharmacological Treatment;Phenotype;Pragmatic clinical trial;pragmatic trial;predictive modeling;primary outcome;Problem behavior;Public Health;public health relevance;Quality of life;random forest;Randomized;repetitive behavior;Reporting;Research Project Grants;Risk;Risk Factors;Risperidone;Sampling;Self-Injurious Behavior;Services;social communication;standard care;Stroke;Weight;Weight Gain;Work

PROJECT_TITLE: Improving precision use of antipsychotic medication in people with autism


ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative  The Collaborative Pediatric Critical Care Research Network (CPCCRN) includes 24 pediatric intensive care units and an established Data Coordinating Center with independent medical and biostatistical expertise. Build- ing on its strong track record of successful clinical trials and innovative work in immune phenotyping in pediatric sepsis, the CPCCRN will carry out a large-scale multicenter randomized controlled trial using personalized test- ing and targeted management of immune function in infants and children with sepsis-induced multiple organ dysfunction syndrome (MODS), one of the most frequent causes of mortality and morbidity in critical care.

PI_NAMEs: WATT, KEVIN M (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Admission activity;Adult;adverse outcome;anakinra;Biometry;C-reactive protein;Child;Childhood;Clinical;clinical research site;Clinical Trials;Collaborations;Communication;Community Healthcare;Critical Care;Critically ill children;Data Coordinating Center;Development;Drug usage;Ethnic Origin;Evidence based treatment;expectation;Family;Ferritin;Frequencies;Functional disorder;Funding;Geography;Granulocyte-Macrophage Colony-Stimulating Factor;health assessment;health related quality of life;Immune;immune function;Immune response;Immune Targeting;Immunologic Adjuvants;Immunologic Monitoring;Immunophenotyping;immunoregulation;Immunosuppression;improved;improved outcome;Infant;Inflammation;innovation;Institution;Intervention Studies;Laboratories;Measures;Medical;meetings;Morbidity - disease rate;mortality;Multicenter Studies;Multiple Organ Failure;National Institute of Child Health and Human Development;Observational Study;Organ;pathogen;Patients;Pediatric Intensive Care Units;pediatric sepsis;Performance;Pharmaceutical Preparations;Phenotype;Placebo Control;Positioning Attribute;primary outcome;Procedures;Protocols documentation;Race;Randomized;Randomized, Controlled Trials;Research;Research Personnel;Risk Factors;Science;Scientist;secondary outcome;Sepsis;septic;Severities;Site;socioeconomic diversity;Structure;Supportive care;targeted treatment;Testing;Time;timeline;tocilizumab;Treatment Protocols;Universities;Utah;Work


NIH_SPENDING_CATS: Clinical Research;Emergency Care;Patient Safety;Pediatric

PHR: Project Narrative  The Collaborative Pediatric Critical Care Research Network (CPCCRN) includes 24 pediatric intensive care units and an established Data Coordinating Center with independent medical and biostatistical expertise. The University of Utah will provide the Data Coordinating Center to enable CPCCRN to carry out a large-scale multi- center randomized controlled trial using personalized testing and targeted management of immune function in infants and children with sepsis-induced multiple organ dysfunction syndrome (MODS), one of the most frequent causes of mortality and morbidity in critical care.

PI_NAMEs: DEAN, JONATHAN MICHAEL (contact)

PROJECT_TERMS: Accounting;Applied Research;Award;Biological;Biometry;Child;Childhood;Clinical;Clinical Investigator;clinical research site;Clinical Trials Data Monitoring Committees;Collaborations;Communication;Communication Tools;Critical Care;Critically ill children;Data Collection;Data Coordinating Center;data harmonization;data management;Data Set;design;Development;Emergency Care;Enrollment;expectation;experience;Funding;Heart Arrest;human subject protection;immune function;immunoregulation;Infant;Informatics;informatics tool;innovation;Institution;Institutional Review Boards;International;Leadership;Manuals;Medical;Medical Informatics;medical schools;Methods;Monitor;Morbidity - disease rate;mortality;Multiple Organ Failure;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;natural hypothermia;Observational Study;Occupational activity of managing finances;operation;pediatric emergency;Pediatric Intensive Care Units;pediatric pharmacology;Peer Review;Performance;Pharmaceutical Preparations;Pharmacology;Play;Principal Investigator;Production;Productivity;Protocols documentation;Publications;Qualifying;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Role;Sepsis;Site;Specimen;Technology;Testing;Therapeutic;tool development;Training;trial design;Universities;Utah

PROJECT_TITLE: Collaborative Pediatric Critical Care Research Network - Data Coordinating Center


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

PI_NAMEs: CUTTING, LAURIE E (contact)

PROJECT_TERMS: Academic Medical Centers;Address;Affect;Algorithms;analysis pipeline;Area;autism spectrum disorder;Behavioral;Big Data;big-data science;Biological Markers;Caregivers;Categories;Child;Clinical;cluster computing;Communities;cost effective;cost efficient;Data;data acquisition;Data Analyses;Data Collection;data de-identification;data management;data pipeline;data platform;data repository;Data Set;Databases;design;Development;disability;Disability research;Discipline;Disease;Down's Syndrome;Education;Electroencephalography;Ensure;Event-Related Potentials;Experimental Designs;Faculty;Funding;Goals;High Performance Computing;Human;Image;image processing;imaging capabilities;improved;Individual;individualized medicine;Infant;innovation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Intellectual Interest;interdisciplinary collaboration;Machine Learning;Magnetic Resonance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;member;Methods;Mission;Modality;Morphologic artifacts;Motion;mouse model;Movement;neural;neuroimaging;neurophysiology;novel;Persons;Population;Prevention;Productivity;programs;Protocols documentation;Psychophysiology;public health relevance;repository;Research;Research Design;Research Personnel;Resources;Scanning;Science;Scientist;Services;Site;Source;Special needs;Special Population;targeted treatment;Technical Expertise;Techniques;Testing;tool;translational neuroscience;Translations;Universities;visual tracking;Work

PROJECT_TITLE: Core C: Translational Neurosciences Core


ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE: The goals of the Baylor IDDRC are to identify the causes of intellectual and developmental disabilities (IDD), study these disorders, develop safe therapies to improve the lives of afflicted individuals, engage with IDD communities and train next generation of researchers.

PI_NAMEs: NAGAMANI, SANDESH CHAKRAVARTHY SREENATH (contact);NELSON, DAVID LOREN

PROJECT_TERMS: Acceleration;Advanced Development;Age;animal model development;base;Basic Science;Biological Markers;biomarker panel;Blood;Caring;Cells;Clinical;clinical heterogeneity;Clinical Research;clinical translation;clinical trial readiness;Clinical Trials;Collaborations;college;Communication;Communities;community partnership;Core Facility;cost effective;Cost Effectiveness Analysis;Coupled;Development;Dimensions;Disability research;Disease;DNA;drug discovery;Education;education planning;educational atmosphere;Environment;Fostering;Future;Gene Dosage;gene therapy;Generations;Genetic;Goals;Human Genetics;improved;in vivo Model;Individual;Influentials;Infrastructure;innovation;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;International;Intervention;Investigation;Laboratories;Leadership;learning community;Medicine;Mentors;Mentorship;Mission;Molecular;Molecular Genetics;multidisciplinary;Neurons;Neurosciences;next generation;novel diagnostics;novel therapeutic intervention;oligonucleotide therapeutics;operation;Outcome;Pathogenesis;Pediatric Hospitals;Pediatrics;Personal Satisfaction;Phase;Phenotype;Philosophy;Physicians;Play;Population;pre-clinical;preclinical study;programs;Psychiatry;Quality of life;recruit;Reproducibility;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Role;Safety;Science;Scientist;Services;Shapes;specific biomarkers;Study models;synergism;Techniques;Texas;Therapeutic;therapeutic development;Tissues;Training;Translational Research;Vision;Whole Organism

PROJECT_TITLE: Baylor College of Medicine Intellectual and Developmental Disabilities Research Center


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative The standard-of-care way in clinical oncology to evaluate the drug response of a tumor is through in vitro and ex vivo protocols done on cells or tissues excised from the live tumor, which is incapable of investigating many important and often critical events that only occur in vivo. The proposed multi-modality microimaging-microdevice (MI-MD) system provides such a technology for high throughput testing of drug response in vivo, without the need to excise any tissues from the native tumor. The MI-MD system to be developed in this project will have high potential impacts on drug development, individualized health care, and fundamental biomedical research.

PI_NAMEs: LIU, GUIGEN  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: 3-Dimensional;4D Imaging;Adoption;Award;Biomedical Research;Biopsy;brain tissue;Calibration;career;career development;Catheters;Cell Death;Cells;Clinical;clinical application;Clinical Oncology;Color;Custom;Dependence;design;Development;Development Plans;Diffusion;Doctor of Philosophy;Dose;Drug Delivery Systems;drug development;drug efficacy;Drug Evaluation;Drug Exposure;drug testing;Engineering;Environment;Evaluation;Event;Excision;experience;experimental study;Fiber Optics;flexibility;Fluorescence;fluorescence imaging;Four-dimensional;Future;Generations;Goals;Healthcare;high throughput technology;high-throughput drug screening;Histologic;Hospitals;Image;Imaging Device;imaging probe;imaging system;Imaging technology;Immune;immune cell infiltrate;Implant;In Situ;In Vitro;in vivo;in vivo evaluation;in vivo imaging;innovation;instructor;interest;Intervention;Investigation;Label;Laboratories;Laboratory Research;Lasers;leadership development;Learning;Length;lens;Location;Manuscripts;Massachusetts;MC38;Mechanics;medical schools;Mentors;Methods;microdevice;Microscopy;minimally invasive;multimodality;Needles;optical fiber;optical imaging;Optics;Organ;Paper;Patients;Pharmaceutical Preparations;post-doctoral training;Procedures;programs;Protocols documentation;Publications;Publishing;Quantitative Evaluations;quantitative imaging;Radiology Specialty;Raman Spectrum Analysis;Reporting;Research;Research Activity;Research Personnel;Resolution;Resources;response;sensor technology;Signal Transduction;Silicon;Site;skill acquisition;skills;Skin Tissue;Speed;standard of care;Subcutaneous Tissue;success;System;Systems Development;Technology;Testing;Three-Dimensional Imaging;Time;Tissues;tool;Training;Training Activity;Translating;translational oncology;tumor;Tumor Tissue;two-dimensional;two-photon;Visualization;Woman

PROJECT_TITLE: Four-dimensional multi-modality microimaging-microdevice system for high throughput drug screening in vivo


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Precision Medicine

PI_NAMEs: HARRISON, FIONA EDITH (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;Affect;animal data;Animal Model;Animal Testing;Animals;Area;Articulation;autism spectrum disorder;Basic Science;Behavior assessment;behavior observation;Behavioral;behavioral phenotyping;Caregivers;Caring;Clinical;Clinical assessments;Communities;community involvement;Complement;Complex;Computer software;Consultations;Data;Data Analyses;Data Collection;data integration;Data Science Core;design;Development;disability;Disease;Down's Syndrome;Encapsulated;Equipment;experience;Experimental Designs;fabrication;Family;Fee-for-Service Plans;Funding;Generations;Goals;Grant;Home;home test;Human;human data;human model;improved;Individual;individualized medicine;Infrastructure;innovation;instrumentation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Intervention;investigator training;Laboratories;laboratory experience;Language;large datasets;Manuscripts;Measurement;Measures;Methods;Modeling;mouse model;new technology;non-verbal;novel;novel strategies;Outcome;Output;Persons;Phenotype;phenotypic data;Physiological;Population;pre-clinical;Precision therapeutics;predictive marker;Protocols documentation;public health relevance;Quality of life;Reproducibility;Research;Research Personnel;Research Training;Resources;response;Rodent;Rodent Model;Services;success;targeted treatment;Testing;testing services;tool;Training;Translating;translational barrier;translational neuroscience;Translational Research;Vulnerable Populations;wearable device;Work

PROJECT_TITLE: Core D: Behavioral Phenotyping Core


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Neurosciences;Pediatric;Sleep Research

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Only two in eight young adults (18-30 years old) with type 1 diabetes achieve glucose targets and a majority are at an increased risk for complications such as premature coronary artery disease, stroke, vision loss, kidney disease and nerve damage compared to the general population. The primary goal of this study is to determine whether a cognitive-behavioral sleep self-management intervention can improve sleep health and glucose targets in young adults with type 1 diabetes. The key findings generated from this study including wearable technologies (e.g., actigraphy and continuous glucose monitors) may help support provider clinical decision making and self-management for young adult with type 1 diabetes to help them achieve glucose targets.

PI_NAMEs: GRIGGS, STEPHANIE ALISHA (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Achievement;actigraphy;Acute;Adolescent;Adult;Affect;Age;alertness;American;arm;attentional control;behavior change;Behavior Therapy;Behavioral;Blindness;Blood Glucose Self-Monitoring;Body Weight;burden of illness;career;Caring;Chronic;Clinical;Clinical and Translational Science Awards;clinical decision-making;Cognition;Cognitive;cohort;college;comparison intervention;Continuous Glucose Monitor;Coronary Arteriosclerosis;Data;diabetes distress;Diabetes Mellitus;diabetes self-management;Dimensions;Distress;Drowsiness;Economic Burden;efficacy evaluation;Enrollment;Ensure;Environment;Female;General Population;ghrelin;Glucose;glucose tolerance;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Health;high risk;Hour;impaired glucose tolerance;Impairment;improved;improvement on sleep;Information Systems;innovation;Insulin;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Intervention;Kidney Diseases;Laboratories;Leptin;Life;macrovascular disease;Measurement;Measures;Mediating;middle age;Modeling;motivational enhancement therapy;nerve damage;novel;Ohio;Outcome;Patient Outcomes Assessments;Patient Self-Report;Phase;poor sleep;Population;post intervention;premature;primary outcome;Provider;Randomized;recruit;Regulation;Research Personnel;response;Risk;satisfaction;Science;Self Management;Sleep;Sleep Deprivation;Sleep disturbances;sleep health;Stroke;Subgroup;Symptoms;Target Populations;Techniques;Theoretical model;therapeutic target;Time;tool;treatment as usual;United States National Institutes of Health;Universities;University Hospitals;wearable device;young adult

PROJECT_TITLE: A Cognitive Behavioral Sleep Self-Management Intervention for Young Adults with Type 1 Diabetes

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: ARLINGTON

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: PROJECT NARRATIVE Prevention of child maltreatment (CM), exposure to domestic violence (DV) and other ACEs are of paramount importance to individual, family and community wellbeing. To address the needs of families at risk for ACEs, we propose to adapt and pilot an innovative prevention program combining family-focused (Multiple Family Groups or MFG), school-based (School Children and Their Families or SAF), financial economic empowerment (FEE) interventions to promote positive health and socioeconomic outcomes for children and families. Although there is strong evidence about the efficacy of each of these interventions individually in the general population in the U.S. and other global contexts, these approaches have never been deployed jointly or adapted and rigorously evaluated among Central Asian (CA) populations; therefore, the proposed study will adapt and carry out this combined prevention program on a pilot basis in Kyrgyzstan and assess its overall effectiveness qualitatively and through a randomized trial.

PI_NAMEs: CHILDRESS, SALTANAT  (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Address;Adolescent;adverse childhood events;Affect;Area;arm;Asian;Asian population;Award;behavioral outcome;career;Caregivers;Caring;Child;Child Abuse and Neglect;Child Rearing;Clothing;Communities;community engaged approach;Data;design;Development;Domestic Violence;Eastern Europe;economic outcome;Economics;Effectiveness;emotional abuse;empowerment;evidence base;Evidence based program;experience;Exposure to;Faculty;Family;Family Policy;first grade;Food deprivation (experimental);Funding;General Population;girls;global health;health economics;High Prevalence;high risk;high school;Immigrant;implementation research;implementation science;improved;Individual;innovation;Intervention;intervention effect;Interview;Kazakhstan;Kidnappings;kindergarten;Knowledge;Kyrgyzstan;Leadership;Light;Link;Literature;Location;low and middle-income countries;Marriage;Measurement;Measures;Medical;Mental Health;Mentored Research Scientist Development Award;Mentors;Methods;Moldova;National Institute of Child Health and Human Development;Nature;neglect;Orphan;Outcome;Parent-Child Relations;Parents;Personal Satisfaction;physical abuse;pilot test;Population;Positioning Attribute;Poverty;prevent;Prevention;Prevention program;Prevention Research;Primary Schools;Process;programs;protective factors;randomized trial;Recording of previous events;Refugees;Reporting;Research;Research Personnel;Research Support;Rest;Risk;Risk Factors;Risk Reduction;Role;Sampling;Schools;Science;Services;Site;skills;social;socioeconomics;sound;Stress;stressor;Test Result;Testing;Training;treatment arm;UNICEF;United States National Institutes of Health;uptake;Verbally abusive behavior;Violence;Work

PROJECT_TITLE: Integrating Evidence-based Approaches to Prevent Child Maltreatment in Kyrgyzstan

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Brain Disorders;Data Science;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

PI_NAMEs: KANG, HAKMOOK  (contact)

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Affect;Animal Model;Applications Grants;autism spectrum disorder;Award;Behavioral;Big Data;biobehavior;Bioinformatics;biomedical imaging;Biometry;Caregivers;clinical translation;Collaborations;Complex;complex data;Consultations;Data;Data Analyses;data de-identification;data mining;data resource;Data Science;Data Science Core;Data Set;Databases;disability;Disease;Down's Syndrome;Education;Electronic Health Record;Faculty;Funding;Future;Generations;Genetic;Goals;Grant;Health;Housing;human model;Human Resources;Image;improved;improved outcome;Individual;individualized medicine;informatics infrastructure;innovation;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Interdisciplinary Study;large datasets;large scale data;Link;Methodology;Methods;Modeling;Modernization;multimodal data;neuroimaging;neuroinformatics;neurophysiology;novel;Outcome;patient oriented;Persons;Population;Productivity;programs;Psychology;public health relevance;Rare Diseases;Records;Reproducibility;Research;research and development;Research Design;Research Personnel;Research Project Grants;Resources;Role;Sample Size;Sampling;Services;Source;spatiotemporal;Statistical Data Interpretation;Statistical Methods;Statistical Models;statistics;Structure;success;Talents;targeted treatment;Techniques;Testing;tool;Training;Training Activity;translational neuroscience;Universities;Work

PROJECT_TITLE: Core E: Data Sciences Core


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Hematology;Infectious Diseases;Kidney Disease;Pediatric;Sepsis

PHR: PROJECT NARRATIVE – Baylor College of Medicine/Texas Children’s Hospital Baylor College of Medicine Texas Children’s Hospital and Children’s Hospital of San Antonio look forward to being new clinical sites in the newly organized and expanded Collaborative Pediatric Critical Care Research Network (CPCCRN). Our participation will contribute significantly to the success of CPCCRN, development of talented clinician scientists, and completion of our highly innovative clinical trial aimed at reducing the morbidity and mortality of multiple organ dysfunction in critically ill infants and children.

PI_NAMEs: AKCAN ARIKAN, AYSE  (contact)

PROJECT_TERMS: Acute Lung Injury;Acute Renal Failure with Renal Papillary Necrosis;Admission activity;Area;Arrhythmia;Attenuated;Beds;Bile Acids;Blood;Blood Platelets;Cardiac;Cardiac Surgery procedures;Cardiomyopathies;Cardiovascular system;career development;Catchment Area;Center for Translational Science Activities;Child;Childhood;Cirrhosis;Clinical;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;cohort;Collaborations;college;Communities;Contracts;COVID-19;Critical Care;Critical Illness;Data;Data Coordinating Center;Development;Digestive System Disorders;Disease;Drug Kinetics;Endothelium;Enrollment;Ethics;ethnic diversity;Ethnic Origin;expectation;Extramural Activities;Faculty;Family suidae;Fostering;Functional disorder;Funding;Goals;Good Clinical Practice;Grant;Heart;Hematology;Hispanic;Hospitals;Immune;Immune System Diseases;immunoregulation;improved outcome;Individual;Infant;Inflammation;Inflammatory;innovation;Intensive Care;International;Intervention Trial;Investigational Drugs;Kidney;Leadership;Leukocytes;Life;Liver;Liver Failure;machine learning algorithm;mechanical circulatory support;Medical center;medical specialties;Medicine;meetings;Mentored Clinical Scientist Development Program;Mentors;Mission;Modeling;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Multicenter Trials;Multiple Organ Failure;Myocardial;National Institute of Child Health and Human Development;Neonatal;Nephrology;news;novel;novel therapeutics;Oncology;Operative Surgical Procedures;Organ;Outcome;participant enrollment;Pathologic;Patients;Pediatric Acute Lung Injury;pediatric department;Pediatric Hospitals;Performance;Persons;Phenotype;Population;Population Heterogeneity;porcine model;pre-clinical;Principal Investigator;Procedures;programs;prospective;Proteins;Protocols documentation;Publications;Randomized;Recording of previous events;Reporting;Research;Research Institute;Research Personnel;Research Project Grants;Research Training;Resources;Respiratory Diaphragm;Scientist;Sepsis;septic patients;Services;Site;success;System;Talents;Techniques;Texas;Therapeutic Agents;Thrombosis;Training;Training Programs;Translational Research;United States;United States Food and Drug Administration;United States National Institutes of Health;Work

PROJECT_TITLE: Collaborative Pediatric Critical Care Research Network - Clinical Site


NIH_SPENDING_CATS: Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PI_NAMEs: ZOGHBI, HUDA Y (contact)

PROJECT_TERMS: animal model development;base;Basic Science;Cells;Clinical;clinical translation;clinical trial readiness;Clinical Trials;Collaborations;college;Communication;Communities;community partnership;Core Facility;cost effective;Dedications;design;Development;Diagnostic;Disease;Education;education planning;Ensure;faculty research;faculty support;Fostering;Funding;Future;Gene Dosage;gene therapy;Genetic;Goals;Human;improved;Individual;Influentials;innovation;Institution;Institutional Review Boards;Intellectual and Developmental Disabilities Research Centers;International;Investigation;investigator training;Knowledge;Laboratories;Leadership;Measures;Medicine;Mission;Molecular;Monitor;multidisciplinary;next generation;novel diagnostics;novel therapeutic intervention;oligonucleotide therapeutics;Outcome;Participant;Pathogenesis;Persons;Play;Population;pre-clinical;preclinical study;programs;Publications;recruit;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Role;Services;specific biomarkers;Study models;synergism;Therapeutic Intervention;therapy development;Tissues;Training;Work

PROJECT_TITLE: ADMINISTRATIVE CORE


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE This mHealth project seeks to address some of the most pressing and current public health concerns, namely extremely high rates of maternal and perinatal deaths in resource-poor settings. Our study proposes to adapt and test the University of Alabama at Birmingham's (UAB) 24/7 Medical Information Service via Telephone (MISTTM) for rural providers for use with mobile-phone technology (mMIST) in Cameroon, a low-income nation that holds some of the highest rates of maternal mortality and perinatal mortality globally. We will accomplish this by partnering with the Cameroon Baptist Convention Health Services (CBCHS), the local Ministry of Health authority, and the African Coalition of the Global Health Committee of the Society of Maternal-Fetal Medicine; this study employs a stakeholder participatory approach and stepped wedge cluster randomized trial design in 19 health districts (clusters) informed by the validated ADAPT-ITT model for intervention adaptation and the Implementation Science (IS) Exploration, Preparation, Implementation, Sustainment (EPIS) framework, making this study scientifically rigorous and innovative.

PI_NAMEs: BUDHWANI, HENNA ;ENAH, COMFORT CHU;TITA, ALAN THEVENET N. (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Administrator;adverse pregnancy outcome;Advisory Committees;Africa;African;Alabama;Attention;authority;Baptist Church;barrier to care;Cameroon;care providers;care seeking;care systems;Caring;Cellular Phone;Cessation of life;Childhood;Clinical;Clinical Protocols;Cluster randomized trial;Collaborations;Consultations;Country;Data;Death Rate;Development;Discipline of obstetrics;Effectiveness;effectiveness evaluation;effectiveness testing;Ensure;Equipment;Evaluation;evidence base;experience;Exploration, Preparation, Implementation, and Sustainment;fetal;fetal medicine;Focus Groups;Fostering;global health;Government;Guidelines;Health;health care availability;Health Services;Health Services Accessibility;Healthcare;High-Risk Pregnancy;Hospitals;Hotlines;implementation evaluation;implementation science;improved;improved outcome;Incidence;Income;Information Services;innovation;Intervention;intervention delivery;Interview;Life;Location;Low income;low income country;maternal morbidity;Maternal Mortality;Maternal-fetal medicine;Measures;Medical;Medical emergency;Methods;mHealth;mobile computing;Modeling;multidisciplinary;Myeloma Proteins;Neonatal;neonatal morbidity;Neonatology;Newborn Infant;Organizational Models;Outcome;Ownership;Patient Transfer;Patients;Perinatal;Perinatal Care;Perinatal mortality demographics;perinatal outcomes;Peripheral;Phase;point of care;Pregnancy Outcome;Pregnant Women;Prenatal care;Primary Care;Protocols documentation;Provider;Public Health;Qualitative Methods;Quality of Care;referral services;research study;Resource-limited setting;Rural;satisfaction;scale up;service providers;Services;skills;social structure;Societies;Specialist;standard of care;Support System;symposium;Technology;Telephone;Testing;Time;Transportation;trial design;United States;Universities;Use Effectiveness;Woman;World Health Organization

PROJECT_TITLE: Medical Information Service via mobile Telephone (m-MIST TM) Provider Support to Improve Pregnancy Outcomes


PI_NAMEs: NAGAMANI, SANDESH CHAKRAVARTHY SREENATH (contact)

PROJECT_TERMS: Academia;Award;Basic Science;bench to bedside;Bioinformatics;Biological;Biological Markers;Biological Specimen Banks;Caring;Clinic;Clinical;Clinical Investigator;clinical outcome assessment;Clinical Research;clinical translation;clinical trial readiness;Clinical Trials;Collaborations;Collection;college;comparative efficacy;Coupled;Data;Databases;design;Development;Diagnosis;Diagnostic;Disability research;Disease;driving force;Drug Industry;E-learning;efficacy study;Environment;first-in-human;Fostering;Funding;Future;Genetic;Genomics;Good Clinical Practice;Grant;Human;Human Subject Research;Infrastructure;insight;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;International;Internet;Laboratories;lectures;Medicine;Mentorship;metabolomics;Modality;model organism;Molecular;Morbidity - disease rate;Natural History;Nervous System;Neurodevelopmental Disorder;next generation;novel;novel diagnostics;novel therapeutics;Outcome;Outcome Measure;patient biomarkers;patient registry;Patients;Phenotype;Positioning Attribute;pre-clinical;Process;Proteomics;Publications;Publishing;Rare Diseases;Research;Research Activity;Research Design;Research Infrastructure;Research Personnel;Resources;Sampling;Scholarship;Scientist;Services;Structure;success;System;Techniques;Therapeutic Intervention;therapy development;Training;transcriptomics;Translating;Translational Research;translational scientist;translational study;Translations;trial design;United States;United States National Institutes of Health;Validation;Vision;webinar;Work

PROJECT_TITLE: CLINICAL TRANSLATION CORE


PHR: PROJECT NARRATIVE – Children's Hospital Los Angeles Children's Hospital Los Angeles is excited to be a member of the Collaborative Pediatric Critical Care Research Network and will bring valuable scientific expertise to the network related to pediatric mechanical ventilation and respiratory diseases, data science, and informatics. We are fully committed to be an engaged member of the network and recruit critically ill patients with sepsis into a clinical trial.

PI_NAMEs: KHEMANI, ROBINDER  (contact)

PROJECT_TERMS: Admission activity;Anesthesiology;Anticoagulation;Beds;Binding Sites;Biological;Biomedical Engineering;California;Cardiac;Cardiopulmonary Bypass;Caring;Child;Childhood;Clinical;clinical center;clinical research site;Clinical Trials;Coagulation Process;Collaborations;Complement;computerized;Consensus;Contracts;County;Critical Care;Critical Illness;Data;Data Coordinating Center;Data Science;design;Development;Emotional;Enrollment;Ensure;Epigenetic Process;ethnic diversity;Ethnic Origin;expectation;Faculty;functional status;Funding;Future;Genetic;Goals;Good Clinical Practice;Health;health related quality of life;Hemorrhage;Hispanic;Immune;immunoregulation;implementation science;Individual;Infant;Informatics;Infrastructure;innovation;interest;International;Knowledge;Leadership;Los Angeles;Lung;Mechanical ventilation;Medicine;meetings;member;Mentors;Mentorship;Methods;Monitor;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;multidisciplinary;National Heart, Lung, and Blood Institute;Neonatology;Neurocognitive;Observational Study;Oranges;participant enrollment;Patients;Pediatric Acute Lung Injury;Pediatric Acute Respiratory Distress Syndrome;Pediatric Hospitals;Pediatric Intensive Care Units;Performance;Phenotype;Positioning Attribute;Practice Guidelines;Procedures;Productivity;Protocols documentation;pulmonary function;Pulmonology;Qualifying;Race;racial diversity;recruit;Research;Research Personnel;Research Training;respiratory;Respiratory Diaphragm;Respiratory Disease;Running;Sampling;Scientist;Sepsis;Site;socioeconomic diversity;Socioeconomic Factors;success;support tools;symposium;Talents;translational scientist;treatment and outcome;United States National Institutes of Health;ventilation;Ventilator;virtual;Work