ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cachexia;Clinical Research;Clinical Trials and Supportive Activities;Physical Activity;Prevention

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Older adults often fear loss of independence and the inability to stay in their homes as they age. There is a need to identify the mechanisms behind this loss of function and to evaluate interventions which could help older adults maintain their autonomy. Thus, this proposed pilot clinical trial will: 1) intervene to minimize the impact of frailty using a home-based exercise program, administered through a meal delivery service, in homebound older adults, and 2) explore possible specific frailty biomarkers to target for early interventions.

PI_NAMEs: LEE, JESSICA LAN (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Accelerometer;Adverse event;Age;age related;Age Years;aging in place;Award;Biological Markers;Biometry;Body Weight decreased;C-reactive protein;Cancer Cachexia;career;career development;catalyst;Categories;Censuses;Characteristics;Chronic Disease;Clinical;Clinical Pathways;Clinical Trials;Communities;comparison control;Control Groups;cytokine;Data;Development Plans;disability;Early Intervention;Elderly;Enrollment;Etiology;Exercise;exercise intervention;exercise program;experience;extracellular;Fatigue;frailty;Fright;functional decline;Functional impairment;Funding;Future;Gait speed;Geriatrics;Goals;Grant;Hand Strength;Health;Heat-Shock Proteins 70;Home;Home visitation;human old age (65+);improved;Inflammatory;inflammatory marker;Institution;Interleukin 6 Receptor;Interleukin-6;Intervention;Intervention Studies;K-Series Research Career Programs;Link;loss of function;Macrophage;Macrophage Inflammatory Proteins;Meals on Wheels;Measures;Mentors;Mentorship;Modality;modifiable risk;Molecular;Monitor;mortality;multi-component intervention;Mus;muscle form;Muscular Atrophy;novel;Nursing Homes;Nutritional Support;older adult;Participant;participant enrollment;Patients;Pattern;Persons;Phenotype;Physical activity;Physician Executives;Physicians;Population;Prevalence;prevent;primary care services;promote resilience;randomized, clinical trials;Randomized, Controlled Trials;Research;resilience;Risk;Risk Factors;Scientist;Serum;service delivery;Services;skeletal muscle wasting;success;supportive environment;Surveys;Syndrome;systemic inflammatory response;Testing;Therapeutic;Time;TNF gene;TNFRSF1A gene;Toll-like receptors;Training;Treatment Effectiveness;treatment group;tumor;walking speed

PROJECT_TITLE: A Meal Delivery and Exercise Intervention to Increase Resilience in Homebound Older Adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BERKELEY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative A more complete understanding of the complex microbial communities that inhabit the human body is needed in order to develop new strategies to manipulate these communities for beneficial health outcomes. This research addresses this need by examining the vitamin B12 family of essential metabolites that are shared among bacteria and can influence microbial community structure.

PI_NAMEs: TAGA, MICHIKO E. (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Address;Amino Acids;Automobile Driving;Bacteria;Biochemical Pathway;Biochemistry;Bioinformatics;bioinformatics pipeline;Cobalt;Coenzymes;cofactor;Communities;Complex;Corrinoids;design;Development;Environment;Enzymes;Family;Foundations;Funding;Genes;Genetic;genetic approach;Genome;Goals;Health;Human;Human body;human model;Metabolic;Metabolism;Methods;microbial community;Microbiology;microorganism interaction;Modeling;Molecular;National Institute of General Medical Sciences;nucleobase;Outcome;Planet Earth;predictive signature;preference;programs;Reaction;Research;Sampling;Specificity;Structure;System;Testing;Vitamin B 12;Work

PROJECT_TITLE: Bacterial Corrinoid Metabolism Across Scales: From Molecular Specificity to Community Dynamics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Natural Products;Nutrition;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: ROCHESTER

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Older cancer survivors are at 46% greater risk of being physically frail compared to those without a history of cancer and older Black cancer survivors are at 18% greater risk of being frail compared to older white survivors. An Epigallocatechin-3-gallate (EGCG) intervention is a safe, feasible, and promising intervention to reduce physical frailty in older cancer survivors. The proposed study will evaluate the preliminary effect of the EGCG intervention on physical frailty and Tumor Necrosis Factor-alpha (TNF-α) and related immune markers, explore if baseline TNF-α and related immune markers and DNA methylation age are associated with physical frailty, and explore the effect of the EGCG intervention on physical frailty and TNF-α and related immune markers in older Black compared to white cancer survivors.

PI_NAMEs: GILMORE, NIKESHA  (contact)

PROGRAM_OFFICER_NAME: VAHEDI, SHAHROOZ

PROJECT_TERMS: Address;Adherence;Adverse event;Age;age acceleration;age related;aging related;Anti-Inflammatory Agents;Anxiety;arm;Ascorbic Acid;Basic Science;Behavior Therapy;Biological;Biological Markers;Biometry;Black Populations;Black race;cancer clinical trial;Cancer Control;Cancer Survivor;cancer therapy;capsule;career development;Catechin;Clinical Research;clinical trial participant;Clinical Trials;Collaborations;design;Development Plans;disadvantaged background;DNA Methylation;Dose;Elderly;Epigallocatechin Gallate;Epigenetic age;Epigenetic Process;Equity;equity, diversity, and inclusion;Feasibility Studies;frailty;functional decline;Functional disorder;Funding;Goals;Green tea;health disparity;health equity;high risk;human old age (65+);Immunologic Markers;improved;improved outcome;Individual;Inflammation;innovation;International;Intervention;Intervention Trial;Lead;Malignant Neoplasms;Measures;Medical;Mental Depression;Mentors;Mentorship;Morbidity - disease rate;mortality;novel marker;Nutraceutical;older adult;Oncology;Oral;Pathway interactions;Patients;Phase;Physical Performance;Placebos;Positioning Attribute;post intervention;predictive marker;Preparation;psychosocial stressors;racial minority status;Randomized;randomized placebo controlled trial;randomized placebo-controlled clinical trial;randomized, clinical trials;Recording of previous events;Research;research and development;Research Priority;Risk;Risk Reduction;Serum;skills;standard care;Study Subject;Survivors;Syndrome;Testing;Time;TNF gene;Training;Translational Research;translational scientist;Treatment/Psychosocial Effects;Vulnerable Populations;Work

PROJECT_TITLE: A Phase II Randomized Placebo Controlled Trial of Epigallocatechin-3-Gallate (EGCG) on Physical Frailty and Tumor Necrosis Factor-alpha and Associated Immune Markers in Older Cancer Survivors

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Patient Safety

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative The goal of the National Clinical Trials Network Lead Academic Participating Site at UPMC Hillman Cancer Center, is to increase our level of participation in conceptualization, development, activation, performance, and reporting on the late-phase clinical trials of the NRG Oncology, ECOG-ACRIN, and Alliance for Clinical Trials in Oncology Network Groups.

PI_NAMEs: BRUFSKY, ADAM M (contact);KIRKWOOD, JOHN MUNN

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Academic Medical Centers;Address;Adult;American College of Radiology Imaging Network;cancer care;Cancer Center;Cancer Patient;cancer research center director;Clinical;Clinical Data;clinical investigation;Clinical Investigator;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Network;Comprehensive Cancer Center;Country;data management;Development;Eastern Cooperative Oncology Group;Ensure;Genotype;Goals;improved;Infrastructure;Lead;Leadership;Medical;Mentors;Minority;National Cancer Institute;National Clinical Trials Network;New York;Ohio;Oncology;Participant;Patients;Pennsylvania;Performance;Phase;Physicians;Positioning Attribute;Principal Investigator;Process;process improvement;programs;Protocols documentation;Publications;rare cancer;Reporting;Research Personnel;Resources;Rural;Science;Services;Site;skills;Special Population;Structure;translational scientist;University of Pittsburgh Cancer Institute;Work

PROJECT_TITLE: NCI NCTN-Network Lead Academic Participating Site at UPMC Hillman Cancer Center


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: DUQUESNE UNIVERSITY

PHR: Project Narrative  Genomic Competencies for Nurses from Theory to Application: An Online Long Course will increase genomic literacy among a diverse group of nursing doctoral faculty and students. Participants will gain expertise in genetic and genomic competencies, resulting in significant benefits for nursing science, the nursing workforce, and ultimately, for patients.

PI_NAMEs: KRONK, REBECCA ANN (contact);MIHAILESCU, MIHAELA R

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Address;Advisory Committees;Advocacy;Affect;care outcomes;Caring;Censuses;Clinical;clinical practice;Clinical Research;Communication;Competence;Continuing Education;continuing nursing education;cost;Course Content;COVID-19;Development;Discipline of Nursing;Disease;doctoral student;E-learning;Education;Educational process of instructing;Ensure;Environment;Epigenetic Process;Ethical Issues;ethical, legal, and social implication;Ethics;ethnic minority population;Evaluation;Evidence based practice;exome sequencing;Faculty;Family;Genetic;genome sciences;genome sequencing;Genomic medicine;Genomics;Goals;Graduate Degree;Health;health care delivery;health equity;Hispanic;Historically Black Colleges and Universities;improved;Individual;Information Theory;Knowledge;Learning;Learning Module;literacy;Minority Groups;Mission;multimodal modeling;National Human Genome Research Institute;Nurses;Nursing Education;Nursing Faculty;Nursing Students;Nursing Theory;Participant;Patients;personalized approach;personalized health care;Population;population health;Population Heterogeneity;programs;racial minority;racial minority population;recruit;remote delivery;Research;Risk Assessment;satisfaction;Science;Science of genetics;Scientist;Series;skills;social;Source;Specific qualifier value;Students;Surveys;System;Teacher Professional Development;Testing;Training;training opportunity;Translations;Underrepresented Minority;United States National Institutes of Health;whole genome

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_DEPT: OTOLARYNGOLOGY

PHR: Project Narrative: Our proposed studies will identify cellular and molecular markers to better predict immune checkpoint inhibitor (ICI) responses in head and neck squamous cell carcinoma patients treated with different combinations of ICIs. Our studies would facilitate finding novel mechanisms of differential ICI responses by examining differences in distinct T cell populations that harbor different T cell receptors. A unique strength of our proposal is integration of human clinical trial samples and mouse models as a more powerful platform to uncover mechanistic insights that are translatable into the clinical setting.

PI_NAMEs: FERRIS, ROBERT L. (contact);VUJANOVIC, LAZAR ;WANG, JING HONG

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Adjuvant Study;Aftercare;anti-CTLA4;anti-PD-1;anti-PD-L1;anti-PD-L1 therapy;Antibodies;antigen-specific T cells;Blood;cancer immunotherapy;Cancer Patient;Cancer Prognosis;cancer type;Carcinogens;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;checkpoint therapy;Clinical;Clinical Trials;Clonal Expansion;Combination immunotherapy;Coupled;Data;Disease;Future;Head and Neck Squamous Cell Carcinoma;HPV positive;Human;Human Papillomavirus;Immune checkpoint inhibitor;improved;insight;Institution;Link;minimally invasive;Modeling;molecular marker;Molecular Profiling;mouse model;Mus;Neoadjuvant Therapy;Nivolumab;novel;Pathway interactions;Patients;Peripheral;Peripheral Blood Lymphocyte;Phenotype;Population;programmed cell death protein 1;Publishing;Resectable;response;Sampling;single-cell RNA sequencing;Splenocyte;Surrogate Markers;T cell receptor repertoire sequencing;T cell response;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;transcriptome;transcriptomics;tumor;Tumor Antigens;Tumor Expansion;Tumor Immunity;Tumor-Infiltrating Lymphocytes;Validation

PROJECT_TITLE: Identifying cellular and molecular signatures from distinct T cell receptor clonotypes associated with favorable immune checkpoint inhibitor responses in HNSCCs

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Crohn's Disease;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Microbiome

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Symbiotic protists can promote several different immune responses in the intestine, which protect their hosts from enteric pathogens but can exacerbate inflammatory bowel disease. Whether these varied immune responses are due to specific differences in protist species remains unclear. In this proposal, we will identify the protist genes and immune mechanisms that control the intestinal immune response to two symbiotic protists that elicit opposite immune responses.

PI_NAMEs: HOWITT, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: PERRIN, PETER J

PROJECT_TERMS: Adaptive Immune System;Antibiotics;Antigens;Bacteria;Biochemical;CD4 Positive T Lymphocytes;Cells;Cellular Assay;Colon;Crohn's disease;Data;Development;Dietary Fiber;Disease;Disease Outcome;effector T cell;engineered T cells;enteric pathogen;Epithelium;Equilibrium;experimental study;Fermentation;Genes;Genetic;Genome;genome annotation;genomic data;genomic tools;Genomics;Gnotobiotic;gut inflammation;gut microbiome;gut microbiota;Health;Homeostasis;Immune;Immune response;Immune signaling;Immune system;immune system function;Immunity;Immunology;immunoregulation;In Vitro;in vivo;Individual;Inflammasome;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Interferon Type II;Intestines;Kinetics;Life;Maps;Measurement;Measures;Metabolic;Metabolic Pathway;Metabolism;metabolomics;microbial;microbial genome;microbiota;microbiota composition;mouse model;Mucosal Immunity;Mus;nanopore;novel therapeutic intervention;Output;pathobiont;Pathology;phenotypic data;Phylogenetic Analysis;Production;Qualifying;Research;RNA;Sensory;Small Intestines;Succinates;T cell receptor repertoire sequencing;T cell response;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;transcriptome;transcriptomics;Tritrichomonas;Work

PROJECT_TITLE: Impact of symbiotic protists on intestinal T cell homeostasis and inflammation.

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: Princeton

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative The functional role of phase transitions in biology are not well proven, but cancers exist that are caused by mutations in or mistargeting of phase-separating chromatin-binding proteins. I will utilize my understanding of these biophysical processes to mechanistically understand this previously undescribed class of oncogenic transformations and work toward building synthetic systems that can rescue defects in chromatin localization, enzymatic functionality and phase behavior of nuclear condensates seen in cancer progression.

PI_NAMEs: STROM, AMY  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Affect;Agreement;Amino Acid Sequence;anti-cancer research;Area;ARID1A gene;Behavior;Binding;Binding Proteins;Binding Sites;Biological Assay;Biological Sciences;Biology;Biophysical Process;biophysical properties;Biophysics;body volume;Bromodomain;Cancer Biology;cancer diagnosis;Cancer Etiology;Cancerous;cell growth;Cell Nucleolus;Cell Nucleus;Cells;Chromatin;Chromatin Fiber;Chromosomal Rearrangement;Common Neoplasm;Complex;Dana-Farber Cancer Institute;Defect;density;Disease;disease phenotype;DNA Binding Domain;DNA Sequence;driver mutation;Environment;Epigenetic Process;Exclusion;Foundations;Functional disorder;Gene Expression Profile;Gene Order;Genetic;Genetic Transcription;Genome;Genomic Segment;Genomics;Heterochromatin;Human;Image;in vivo;Investigation;Knowledge;Light;Link;Malignant Neoplasms;Mechanics;Mediating;Mentors;Methods;Modeling;Modification;Molecular;Morphology;Mutate;Mutation;next generation sequencing;novel;Nuclear;Nuclear Lamina;Nuclear Structure;Nucleosomes;Oncogenic;optogenetics;Outcome;Output;Pattern;Phase;Phase Transition;Phenotype;Physical condensation;Polymers;Process;protein complex;protein crosslink;Protein Region;Proteins;Research;RNA;Role;Sampling;scaffold;screening;Shapes;Site;Slide;Specificity;Structure;Structure-Activity Relationship;System;Technology;theories;Therapeutic;tool;Training;Transcriptional Activation;transcriptome;tumor progression;tumorigenesis;Universities;viscoelasticity;Work

PROJECT_TITLE: Phase Transitions in Chromatin Organization that cause Cancer Progression

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Precision Medicine;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Integrating whole-genome sequence information to study clinical and subclinical atherosclerosis will increase understanding of why individuals vary in susceptibility to coronary artery disease. This knowledge will open opportunities for precision medicine, improved risk prediction, as well as provide directions for future research.

PI_NAMEs: DE VRIES, PAUL STEFAN (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: African ancestry;Arterial Fatty Streak;Atherosclerosis;Biological;cardiometabolism;cardiovascular risk factor;Cardiovascular system;Carotid Artery Plaques;carotid intima-media thickness;Categories;Clinical;Code;compare effectiveness;Complex;Coronary Arteriosclerosis;Coronary artery;coronary artery calcification;Data;Data Set;Data Sources;Deposition;design;Disease;effectiveness testing;European ancestry;Event;exome sequencing;Frequencies;Gene Frequency;Genes;Genetic;genetic architecture;Genetic Risk;genetic risk factor;genetic variant;Genetic Variation;genome resource;genome sequencing;genome wide association study;genomic locus;Genomics;Genotype;Goals;Heritability;Imaging Techniques;improved;Individual;insight;Knowledge;large scale data;mortality;Myocardial Infarction;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;Nucleic Acid Regulatory Sequences;outcome prediction;Participant;Pathway interactions;Phase;Phenotype;pleiotropism;polygenic risk score;Population;precision medicine;Predisposition;Prevention;Primary Prevention;Procedures;programs;Progressive Disease;Public Health;rare variant;Resources;revascularization;risk prediction;Scanning;Single Nucleotide Polymorphism;Technology;Testing;tool;trait;Trans-Omics for Precision Medicine;Translating;Ultrasonography;United States;Untranslated RNA;Variant;whole genome;X-Ray Computed Tomography

PROJECT_TITLE: Whole-genome sequencing analysis of coronary atherosclerosis and related traits

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Wound Healing and Care

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The lining of the gastrointestinal tract plays an important role in immune defense, which can be significantly compromised by conditions such as inflammatory bowel diseases, ischemia, mechanical injury and surgical procedures. This grant will address mechanisms that control epithelial barrier function, determine the impact of inflammatory mediators on mucosal barrier function and investigate how the mucosal lining heals after injury. Knowledge gained from these studies in the short term will provide a better understanding of basic mechanisms that control epithelial barrier function and wound healing, and in the long term, these studies will aid in the development of new therapeutic strategies aimed at strengthening the barrier and in promoting mucosal wound repair.

PI_NAMEs: NUSRAT, ASMA  (contact);PARKOS, CHARLES A

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Actins;Address;Adherens Junction;Adhesions;Adhesives;Apical;apical membrane;Attenuated;Binding;Biological Process;Biopsy;Cell membrane;cell motility;Cell-Matrix Junction;Clinical;Colon;Complex;Crohn's disease;cytokine;Cytoplasm;Cytoskeleton;Data;Development;Disease;Epithelial Cells;epithelial injury;epithelial repair;epithelial wound;Epithelium;Event;experimental study;F-Actin;Family member;gastrointestinal epithelium;Gastrointestinal tract structure;genetic regulatory protein;Goals;Grant;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;healing;Homeostasis;Human;IL17 gene;Immune;Immunity;In Vitro;in vivo;in vivo evaluation;Individual;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Bowel Diseases;Injury;insight;Integral Membrane Protein;Intercellular Junctions;Interferon Type II;intestinal barrier;intestinal epithelium;Intestinal Mucosa;Intestines;Invertebrates;Ischemia;knock-down;Knowledge;Link;link protein;Malignant Neoplasms;Mammals;Mechanics;Mediating;Membrane;migration;model organism;Modeling;Molecular;Mucous Membrane;Mus;Neurofibromin 2;novel;novel therapeutic intervention;Operative Surgical Procedures;Pathogenesis;Pathologic;Persons;Play;protein complex;protein expression;Protein Family;Proteins;Reagent;Recovery;recruit;Regulation;repair model;repaired;response;rho;rho GTP-Binding Proteins;Role;Scaffolding Protein;Signal Transduction;stem cells;Tertiary Protein Structure;Tight Junctions;TNF gene;Transformed Cell Line;Transgenic Mice;two-dimensional;wound;wound closure;wound healing

PROJECT_TITLE: Polarity proteins and intestinal mucosal responses to inflammation and injury

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE This study seeks to explore the dual functions of eIF5Ahpu in regulating cancer cell proliferation/cancer stem cell properties and polarization of M2-like tumor associated macrophages in OSCC and evaluate the therapeutic effect of targeted inhibition of eIF5Ahpu on OSCC growth and progression in orthotopic tongue SCC models in mice.

PI_NAMEs: LE, ANH D (contact)

PROJECT_TERMS: 3-Dimensional;Amino Acids;analog;Attenuated;Biological Process;BMI1 gene;cancer cell;cancer prevention;cancer stem cell;cancer type;Cell Physiology;Cell Proliferation;Characteristics;chemotherapy;cohort;Data Set;Death Rate;density;deoxyhypusine monooxygenase;deoxyhypusine synthase;Development;Diagnosis;Down-Regulation;eIF-5A;Enzymes;Epithelium;ES01;Genetic;genetic approach;Genetic Transcription;Growth;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Human;hypusine;Immune;Immunocompetent;Immunosuppression;improved;In Vitro;in vivo;Infiltration;irradiation;Lysine;Macrophage;Malignant Epithelial Cell;malignant mouth neoplasm;Malignant Neoplasms;Mediating;Mesenchymal;Metabolism;Mixed Function Oxygenases;Modeling;Molecular;Morbidity - disease rate;mouth squamous cell carcinoma;mRNA Expression;Mus;new therapeutic target;Normal tissue morphology;NOTCH1 gene;novel;novel therapeutics;Nude Mice;Oncogenes;Ornithine Decarboxylase;overexpression;paracrine;Patients;pharmacologic;Phenotype;Play;polyamine oxidase;Polyamines;Post-Translational Protein Processing;Prevention;Prognosis;Proliferating;Property;protein expression;Protein Isoforms;Proteins;Recurrence;RNA-Binding Proteins;Role;Scheme;self-renewal;Signal Pathway;Signal Transduction;Spermidine;Spermidine Synthase;Stromal Cells;Survival Rate;T-Cell Activation;Testing;The Cancer Genome Atlas;Therapeutic Effect;Tongue Squamous Cell Carcinoma;translation factor;Translations;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;TWIST1 gene;Up-Regulation;Western Blotting

PROJECT_TITLE: Targeted inhibition of eIF5Ahpu suppresses tumor growth and M2-like TAM polarization in oral cancer

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: ROCKVILLE

ORG_NAME: SANARIA, INC.

ORG_STATE: MD

PHR: PROJECT NARRATIVE Sanaria has developed highly effective Plasmodium falciparum sporozoite (PfSPZ) vaccines to protect individuals against malaria that are intended also for use in eradicating malaria from defined geographical areas; the first is a live attenuated whole organism vaccine called Sanaria® PfSPZ Vaccine, the second is a live infectious vaccine administered with an antimalarial drug, a vaccine called Sanaria® PfSPZ-CVac, and the third is a late arresting replication competent genetically attenuated vaccine, PfSPZ-LARC2. All these vaccines require the production of PfSPZ in aseptic female Anopheles stephensi mosquitoes. This proposal aims to increase the efficiency of aseptic mosquito rearing by genetically modifying mosquitoes such that immature male mosquitoes are killed by conditional expression of a lethal gene. Successful implementation of this project will reduce cost of vaccine manufacture by ~15%, thereby making the vaccine available at lower cost.

PI_NAMEs: BILLINGSLEY, PETER F. (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Adult;Africa;African;aged;Anopheles Genus;Anti-malarials;Attenuated;Attenuated Vaccines;Automobile Driving;Binding;Bioreactors;Blood;CCL20 gene;Cessation of life;Consumption;cost;Country;CRISPR/Cas technology;Cryopreservation;Culicidae;Disease;DNA cassette;Docking;Dose;Doxycycline;egg;Elements;Embryo;Europe;European;feeding;Female;Gene Deletion;Gene Expression;Gene Modified;Genes;genomic locus;Genomics;Geographic Locations;Germ Lines;Grant;Growth;Hour;Human;Hybrids;Immunization;Impairment;in vivo;Individual;Infection;Ingestion;Insecta;intravenous administration;intravenous injection;Lethal Genes;Link;Maintenance;Malaria;malaria infection;Malaria Vaccines;male;manufacture;manufacturing process;Mediating;Modification;Nutrient;Partner in relationship;pathogenic fungus;Physiologic pulse;Plasmodium falciparum;Plasmodium falciparum vaccine;Prevalence;Prevention;Process;Production;progenitor;promoter;prophylactic;Radiation;recombinase-mediated cassette exchange;red fluorescent protein;Regimen;repaired;Reproducibility;Response Elements;sex;Site;Small Business Innovation Research Grant;Spiders;Sporozoite vaccine;Sporozoites;Sterility;System;technology platform;Testing;Tetracycline Control;Tetracyclines;tool;Toxin;Trans-Activators;Transgenic Organisms;vaccine access;Vaccines;Vial device;Whole Organism;Y Chromosome

PROJECT_TITLE: Conditional male lethal Anopheles stephensi line for the efficient manufacture of malaria vaccines

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-U(11)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project Narrative The community-associated methicillin-resistant Staphylococcus aureus (MRSA) epidemic has significanlty impacted certain patient groups in urban areas, including individuals with incarceration eposure. The objective of this project is to examine the genomic epidemiology of MRSA in the community and identify and characterize epicenters where spread of MRSA is occurring in order to target prevention efforts.

PI_NAMEs: POPOVICH, KYLE JEANNE (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: acquired factor;African American;Area;Back;Bacteremia;care seeking;Caring;Censuses;Chicago;Cities;Clinical;Communities;Community based prevention;community intervention;Community Networks;community setting;community transmission;cooking;County;Data;data integration;Data Set;design;Disparity;Epidemic;Epidemiology;Funding;Genetic;genome sequencing;genomic data;genomic epidemiology;Genomics;Geographic Locations;high risk;Hospitals;Household;housing instability;illicit drug use;Illicit Drugs;Imprisonment;Individual;Infection;Infection prevention;innovation;Interruption;Intervention;Jail;Knowledge;lonely individuals;Medical;methicillin resistant Staphylococcus aureus;Modeling;Molecular Epidemiology;Movement;Neighborhoods;opioid epidemic;pathogen;Patients;Phenotype;Phylogenetic Analysis;Population;Prevention;Proxy;Public Health;Public Hospitals;recidivism;Research;residence;Risk;Risk Factors;Role;Sexually Transmitted Diseases;simulation;Site;social contact;Spatial Distribution;Staphylococcus aureus infection;Testing;Time;transmission process;Trees;Underserved Population;urban area;Urban Community;whole genome;Writing

PROJECT_TITLE: A multi-level genomic and spatial analysis of MRSA transmission

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: AA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Social Determinants of Health;Substance Misuse

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed project engages innovative approaches to study individuals recovering from alcohol use disorder using the International Quit & Recovery Registry. This accelerated longitudinal study seeks to characterize long-term trajectories of recovery (0 to 12 years) including the associated changes in psychosocial functioning and relapse status. Findings will inform decision-process theories of addiction and identify treatment targets to promote improved health during recovery.

PI_NAMEs: KIM-SPOON, JUNGMEEN  (contact);TEGGE, ALLISON N

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Acceleration;addiction;Address;alcohol abuse therapy;Alcohol consumption;alcohol use disorder;Computer Models;Data Collection;Dimensions;discounting;Disease remission;editorial;Emotional;Environment;Event;Exhibits;Future;Geography;Goals;Health;improved;Impulsivity;indexing;Individual;Individual Differences;innovation;International;Length;Life Style;long term recovery;longitudinal design;Longitudinal Studies;Measurement;Measures;Mediating;Mental Health;Methods;Modeling;National Institute on Alcohol Abuse and Alcoholism;Nature;neurobehavioral;Neurosciences;novel;online resource;Participant;Pathway interactions;Patient Recruitments;perceived stress;Phenotype;physical conditioning;preventive intervention;Principal Investigator;Privacy;Process;promote resilience;prospective;psychosocial;Quality of life;Recording of previous events;Recovery;recruit;Registries;Regulation;reinforcer;Relapse;relapse prevention;repaired;Research;Research Project Grants;Resistance;Sampling;sex;social;social relationships;Social support;socioeconomics;Specific qualifier value;Subgroup;Symptoms;System;Testing;theories;Time;Variant;Vocation

PROJECT_TITLE: Longitudinal Study of Recovery: Psychosocial Functioning, Relapse, and Neuro-Behavioral Markers

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Aging;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative In this proposal, we will use biochemical assays, mouse models and cell lines to understand how single-strand DNA binding proteins regulate telomere end protection, length regulation and replication.

PI_NAMEs: CHANG, SANDY S (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Adopted;Aging;aging related disease;Amino Acids;ATR checkpoint;Binding;Binding Proteins;Biochemical;Biological Assay;Bone marrow failure;Bone Marrow Transplantation;cancer initiation;Cell Aging;Cell Line;Cell Maintenance;Cell Proliferation;Cells;Chromosomal Rearrangement;Chromosome abnormality;Complex;Cytoprotection;Data;Development;DNA Binding;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA replication fork;Dyskeratosis Congenita;Excision;Failure;Functional disorder;Future;Generations;Genes;Genetic;genetic approach;Genome;Genome Stability;Goals;Hematopoietic stem cells;Homeostasis;Homologous Gene;Human;In Vitro;in vivo;Knockout Mice;Length;loss of function;Malignant Neoplasms;Mediating;Metabolism;Molecular;mouse genome;mouse model;Mus;mutant;Mutate;Mutation;Nature;novel;pathological aging;Pathway interactions;Phenotype;Play;premature;Premature aging syndrome;prevent;Property;protein function;Proteins;Public Health;recruit;Regulation;replication factor A;replication stress;Repression;response;Role;single molecule;Single-Stranded DNA;SS DNA BP;stem cell function;stem cells;Structure;Telomerase;telomere;Telomere Length Maintenance;Telomere Maintenance;Telomere-Binding Proteins;Testing;Therapeutic Studies;TP53 gene

PROJECT_TITLE: Role of POT1 in telomere length regulation

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: Complementary and Integrative Health;Genetics;Nutrition;Obesity;Prevention

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Obesity is common, expensive, and resistant to current treatments despite being a focus of intense research. In our preliminary data we have found that high dose dietary vitamin D signals to preferentially allocate calories to muscle instead of fat. Here our goal is to determine which form of vitamin D is responsible for this preferential calorie allocation and to identify the signaling underlying this preferential allocation, thereby identifying novel therapeutic approaches to exploit to decrease both negative effects and incidence of obesity.

PI_NAMEs: ROIZEN, JEFFREY DAVID (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Area;Binding;Binding Sites;Biological Assay;Body Weight decreased;Calcifediol;Calcitriol;Calcium;Caloric Restriction;Calories;career;Cell Culture Techniques;daily functioning;Data;Dedications;Development;Diabetes Mellitus;diabetes risk;dietary;Disease;DNA Binding;Dose;Elements;Enzymes;Exercise;Fatty acid glycerol esters;Gene Expression;Generations;Genes;Genetic Transcription;Genetically Engineered Mouse;genome-wide;genome-wide analysis;Goals;Hand Strength;Health;Heart Diseases;Hydroxylation;improved;In Vitro;in vivo;Incidence;Knock-out;Knockout Mice;Longevity;Malignant Neoplasms;Maps;Measures;Mediating;Metabolism;Mitochondria;Mixed Function Oxygenases;Modeling;mouse model;Mus;Muscle;muscle form;Muscle function;Muscle Mitochondria;muscle physiology;new therapeutic target;novel;novel therapeutic intervention;Obese Mice;Obesity;obesity risk;obesity treatment;Output;Oxidative Phosphorylation;Pathway interactions;Pennsylvania;prevent;professor;Qualifying;Quality of life;receptor binding;Receptor Signaling;Research;Research Personnel;Resistance;response;Risk;Role;Running;Serum;side effect;Signal Pathway;Signal Transduction;targeted treatment;tenure track;Testing;Therapeutic;Thinness;Time;Transcriptional Regulation;transcriptome;transcriptome sequencing;treadmill;Universities;Vitamin D;Vitamin D Response Element;Vitamin D3 Receptor;Work

PROJECT_TITLE: Vitamin D control of calorie allocation to muscle

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The proposed work will generate monoclonal antibodies to treat catheter-associated urinary tract infections (UTI) and deplete the vaginal reservoir that harbors bacteria and contributes to UTI recurrence. The success of monoclonal antibodies as treatments for other diseases as well as significant preliminary data demonstrating the protective effect of immunity to bacterial adhesins, which mediate UTIs, suggest that this will be a highly effective strategy. These studies have the potential to directly contribute to the arsenal of antibiotic-sparing therapeutics for UTIs.

PI_NAMEs: TIMM, MORGAN ROSE WILT (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acinetobacter baumannii;Address;Adherence;Adhesives;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;appendage;Bacteria;Bacterial Adhesins;bacterial resistance;Binding;Bladder;Bladder Urothelium;burden of illness;career;Catalogs;catheter associated UTI;Catheterization;Catheters;Cessation of life;Chronic;Communicable Diseases;COVID-19;Data;Deposition;Development;Disease;Distant;Dose;Enterococcus;Enterococcus faecalis;Environment;Epithelial Cells;Epithelium;experience;experimental study;Fellowship;female reproductive tract;female reproductive tract infection;Fibrinogen;Future;Gastrointestinal tract structure;Genes;global health;Goals;gut colonization;Human;Immunity;Immunization;Immunize;Immunofluorescence Immunologic;Immunology;improved;In Vitro;in vivo;indexing;Infection;Infective cystitis;Inflammatory Response;Institution;Ligands;Mediating;medical schools;Microbial Biofilms;Microbiology;Modeling;Monitor;Monoclonal Antibodies;mouse model;Multi-Drug Resistance;Mus;mutant;Nature;novel therapeutics;pathogen;Pathogenesis;Physicians;Pilum;Play;prevent;Prevention;prophylactic;protective effect;Protein Subunits;Proteins;Quality of life;Recording of previous events;Recurrence;recurrent infection;Research;Research Personnel;Resistance;Resistance development;Role;Safety;Scientist;sex;skills;Source;Specificity;success;Surface;Testing;Therapeutic;therapeutic target;Tissue Stains;Tissues;Training;United States;Universities;Urethra;urinary;Urinary tract infection;Uropathogen;Uropathogenic E. coli;Vagina;Virulence Factors;Washington;Woman;Women's Health;women's treatment;Work

PROJECT_TITLE: Novel therapeutics for treatment of catheter-associated UTI and depletion of the vaginal reservoir


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE There is currently no effective treatment for the cognitive dysfunction characteristic of aging and exacerbated in Alzheimer Disease (AD). Administration of extracellular vesicles (EVs) containing NAMPT, an enzyme critical to cellular NAD+ production, can extend lifespan and ameliorate age-related deficits such as activity levels in mice. This study will evaluate a role for NAMPT in mediating the ability of EVs to target the brain and rescue age- and AD-related cognitive decline, potentially establishing the use of EVs as a viable therapeutic strategy to treat these conditions.

PI_NAMEs: LANANNA, BRIAN VINCENT (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Abate;Acetylation;Adipocytes;Adipose tissue;Age;age related;Age-associated memory impairment;aged;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloidosis;Anabolism;Behavior;behavior measurement;Behavioral;Biological;Biology;Brain;brain cell;C-terminal;career;Cell Culture Techniques;Cell Line;cell type;Cells;cellular targeting;Ceramides;Characteristics;Cognitive;cognitive benefits;Cognitive deficits;cognitive function;cognitive reappraisal;collaborative environment;Critical Pathways;Data;Deacetylase;density;Deposition;Deterioration;effective therapy;effectiveness testing;empowerment;Engineering;Enzymes;extend lifespan;extracellular;extracellular vesicles;Fellowship;flexibility;Functional disorder;Future;gerotherapeutic;hallmarks of aging;healthspan;Hippocampus;Hypothalamic structure;Impaired cognition;improved;In Vitro;in vivo;Injections;knock-down;Knock-in Mouse;Knock-out;Label;Laboratories;Leadership;life span;Limbic System;Location;Longevity;Mammals;Measures;Mediating;Membrane;Memory;Mentorship;morris water maze;mouse model;Mus;Neurons;Neurosciences;NF-kappa B;Nicotinamide adenine dinucleotide;nicotinamide phosphoribosyltransferase;novel;old mice;overexpression;Pathologic;Pathology;Pathway interactions;Peripheral;Plasma;Play;Population;Preparation;Production;Proteins;restoration;Role;secondary endpoint;short hairpin RNA delivery;Signal Pathway;SIRT1 gene;Sirtuins;small hairpin RNA;Stains;success;Symptoms;Synapses;synaptic function;tau Proteins;Testing;Therapeutic;Tissues;trafficking;Training;transcriptome sequencing;ultra high resolution;Universities;uptake;Viral;Washington

PROJECT_TITLE: Investigating a role for eNAMPT-containing extracellular vesicles in mitigating age- and Alzheimer Disease-related cognitive decline


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Palliative Care;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE It is imperative to engage older adults with mild cognitive impairment who are at risk for Alzheimer's Disease and Related Dementias (ADRD) in advance care planning before they develop end-stage disease and lose the capacity to make informed decisions. This proposal has unique public health importance because (1) it will increase the mentoring of clinical investigators interested in conducting patient-oriented research concerning the rapidly growing population of older persons with cognitive impairment and caregivers of persons with cognitive impairment or ADRD; (2) it will inform the adaptation of evidence-based advance care planning interventions for older persons with cognitive impairment and caregivers of persons with cognitive impairment or ADRD; and (3) it will help to reduce health disparities in advance care planning for patients and caregivers.

PI_NAMEs: SUDORE, REBECCA L (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Address;Adult;Advance Care Planning;advanced directive;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;California;Cardiopulmonary Resuscitation;career;career development;Caregiver Burden;Caregiver support;Caregivers;Caring;Chinese;Church;Clinical Investigator;Clinical Research;Communication;community engaged research;community engagement;Companions;Complex;coronavirus pandemic;Decision Making;decision-making capacity;design;Development;Development Plans;digital;Discipline;Disparity;Educational Materials;Educational process of instructing;efficacy testing;end stage disease;Environment;Evaluation;evidence base;Exclusion;Exercise;experience;Face;Faculty;Feedback;Funding;Future;Geriatrics;Goals;Health education;health literacy;Home;Impaired cognition;implementation framework;implementation science;improved;Individual;interest;Intervention;Interview;Leadership;Learning;Libraries;Link;literacy;live stream;marginalization;marginalized community;marginalized population;Medical;Mentors;Mid-Career Clinical Scientist Award (K24);mild cognitive impairment;Modeling;Nephrology;novel strategies;older adult;Older Population;Oncology;Operative Surgical Procedures;Palliative Care;Palliative Medicine;Participant;Patient Care Planning;patient oriented;patient oriented research;Patients;person centered;Persons;Physicians;Positioning Attribute;preference;Preparation;primary care setting;Procedures;Process;programs;Public Health;Publications;Publishing;recruit;Reduce health disparities;Reporting;Research;Research Personnel;Research Project Grants;Research Training;San Francisco;satisfaction;skills;Spanish;Structure;student mentoring;Suggestion;Testing;theories;therapy development;Time;Trust;United States National Institutes of Health;Universities;virtual;virtual group;virtual healthcare;Visit;Work

PROJECT_TITLE: Mentoring Researchers in Advance Care Planning for Underrepresented Older Adults at Risk for Alzheimer’s Disease and Related Dementias and Their Caregivers

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Narrative: Using in vivo models of hematopoietic stem cell transplantation the studies will generate the first cellular atlas of hematopoietic engraftment and define the molecular and cellular mechanisms through which sinusoids and megakaryocytes differentially control hematopoietic stem cell or progenitor function during regeneration. Microanatomical definition of active niches will open translational opportunities in transplantation.

PI_NAMEs: LUCAS, DANIEL  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Ablation;Affect;angiogenesis;Architecture;Area;Atlases;Blood;Blood Cells;Bone Marrow;Bone Marrow Purging;candidate identification;Cells;curative treatments;Data;Development;Discontinuous Capillary;donor stem cell;Engraftment;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic engraftment;hematopoietic stem cell expansion;hematopoietic stem cell niche;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Image;improved;In Situ;in vivo Model;injured;Injury;Label;Maps;Marrow;Megakaryocytes;Methods;Microanatomy;Molecular;Natural regeneration;novel therapeutics;Patient-Focused Outcomes;Patients;prevent;Production;progenitor;Recovery;recruit;regenerative;Role;self-renewal;stem;stem cell differentiation;stem cell division;stem cell engraftment;stem cell expansion;stem cell function;stem cell niche;stem cell proliferation;stem cells;Testing;therapy development;tool;translational potential;Transplantation;virtual

PROJECT_TITLE: Hematopoietic Stem Cell engraftment in the injured niche

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Infectious Diseases;Inflammatory Bowel Disease

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Approximately 24% of the world's population is infected with one or more helminths; on the other hand, the incidence of inflammatory bowel disease in developed countries continues to rise. There is an urgent need for effective and safe treatments for intestinal infections and inflammation; however, our understanding of host defense mechanisms is far from complete. The proposed study will reveal a new regulatory cascade within the intestinal epithelium that enables the host to mount antihelminth immunity and control gut inflammation, thus providing new avenues for the treatment of parasitic infections and inflammatory disorders.

PI_NAMEs: RUAN, HAI-BIN  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Ablation;Allergic Disease;Allergic inflammation;Anthelmintics;Area;Autoimmune Diseases;autoimmune inflammation;CCL4 gene;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell secretion;cell type;Cells;Chronic;citrate carrier;Colitis;Communicable Diseases;cytokine;Cytoplasm;Developed Countries;Development;Disease;enteric infection;Epithelial Cells;Epithelium;Exposure to;extracellular;Future;Gene Family;Genetic;genetic approach;Goals;Goblet Cells;Granuloma;gut inflammation;helminth infection;Helminths;Host Defense;Host Defense Mechanism;Human;Hygiene;Hyperplasia;Immune;Immune response;Immune system;Immunity;Immunologic Stimulation;Incidence;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;interest;Interferon Type II;Interleukins;Intervention;intestinal epithelium;intestinal homeostasis;Intestinal Mucosa;Intestinal parasite;Intestines;Knockout Mice;Knowledge;Laboratories;Link;Lymphoid Cell;Mediating;Medicine;Modernization;Modification;Mucous Membrane;Mus;novel;Organoids;Parasitic infection;pathogen;Pathway interactions;Persons;pharmacologic;Physiological;Physiology;Play;Population;Post-Translational Protein Processing;Poverty Areas;Preventive;Production;Proteins;Research;response;restraint;Role;Serine;Signal Transduction;Societies;Source;STAT6 gene;Testing;Therapeutic;Therapeutic Effect;Threonine;tissue-repair responses;tool;transcription factor;TSLP gene;UDP-N-acetylglucosamine-peptide beta-N-acetylglucosaminyltransferase

PROJECT_TITLE: Intestinal O-GlcNAc signaling and mucosal host defense

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative: Antiretroviral therapy (ART) during HIV-1 infection suppresses viral replication and prevents immunodeficiency but does not cure the infection. We have developed a novel genetically encoded humanized mouse model system that enables us to distinguish latent cells from bystander cells and are now characterizing latent cells using single cell genomic profiling of cells, to reveal an unprecedented unperturbed view HIV latency. We propose here to use single cell genomics, live dynamic imaging and spatial transcriptomics to probe how latent cells survive stimuli that can activate the virus and the immune system.

PI_NAMEs: CHEN, BENJAMIN K (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acute;acute infection;Animal Model;Animals;Antibodies;antiretroviral therapy;Bar Codes;Behavior;Binding;Biological;Biological Models;CD4 Positive T Lymphocytes;Cell Communication;Cell Count;Cell Lineage;Cell Survival;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Classification;Development;Disease Progression;Gastrointestinal tract structure;Gene Expression Profile;Genes;Genetic Transcription;genomic profiling;Genomics;HIV;HIV Infections;HIV-1;Human;humanized mouse;Image;Immune system;immunodeficiency;improved;In Vitro;in vivo;Infection;Interruption;Intervention;Knowledge;Maps;Measures;Memory;Methods;migration;Modeling;Morphology;mouse model;Mucous Membrane;multiple omics;Mus;novel;Pathway Analysis;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;preservation;prevent;programs;Proliferating;purge;Relapse;Research;Resolution;response;Shock;single cell genomics;single-cell RNA sequencing;Spleen;Stimulus;Superantigens;System;Systems Biology;T-Cell Activation;T-Lymphocyte;TCR Activation;Testing;Time;Tissue-Specific Gene Expression;Tissues;transcriptomics;Viral;Viral reservoir;Virus;Virus Replication

PROJECT_TITLE: Single cell transcriptomics of HIV persistence and latency

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Estrogen;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Lung;Lung Cancer;Prevention;Sexually Transmitted Infections

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Lung cancer is the most common and most deadly non-AIDS defining cancer in the HIV(+) population and smoking alone cannot explain the significantly higher rate of lung cancers in HIV(+) individuals. The main focus of this project is to determine the causal role of human papillomavirus (HPV) in HIV associated lung cancers and elucidate the unique mechanism through which HPV contributes to this deadly disease. The discovery of this work is expected to be particularly significant for future patient care and disease management.

PI_NAMEs: LIN, ZHEN  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;AIDS related cancer;Biological Models;Cancer cell line;Cancer Etiology;Cancer Patient;cancer risk;Cause of Death;Cell Culture Techniques;Cells;Cessation of life;circular RNA;Clinical;Data Set;Development;Disease;Disease Management;Epithelial Cells;ESR1 gene;Estrogen Antagonists;Estrogens;Etiology;Exhibits;Feedback;Future;Gene Expression;gene product;General Population;Genetic Transcription;Genomics;Goals;Growth;Highly Active Antiretroviral Therapy;HIV;HPV positive;HPV-High Risk;Human papilloma virus infection;human papilloma virus oncogene;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Immune Evasion;improved;Incidence;Individual;Informatics;Kaposi Sarcoma;knock-down;Lung;lung cancer cell;lung carcinogenesis;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant Neoplasms;malignant phenotype;Mediating;Methods;Microbe;Monitor;next generation sequencing;Non-Hodgkin's Lymphoma;novel;Oncogenes;Oncogenic;Oncoproteins;pathogen;Patient Care;Patients;personalized medicine;Persons;Phenotype;Population;prevent;Regimen;Research;Risk Factors;Role;Sampling;Sensitivity and Specificity;sex;Signal Transduction;Smoking;Smoking Status;Technology;Testing;Therapeutic;Transcript;transcriptome;transcriptome sequencing;tumor;tumor microenvironment;tumor-immune system interactions;tumorigenesis;Viral;Viral Oncogene;Virus Integration;Work

PROJECT_TITLE: Human papillomavirus in HIV associated lung cancers

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE The burden of Alzheimer's disease and related dementias (ADRD) is increasing nationally and globally, with disproportionate impacts on lower-income, lower-education, and minority race/ethnic older adults. Presence of and inequalities in neighborhood factors (e.g. social context or physical and built environments) may affect cognitive decline and be key for intervening on ADRD risk and disparities at the population level. In this study, researchers collect, process, and link extensive neighborhood data to the Multi-Ethnic Study of Atherosclerosis (MESA), creating an unprecedented 25+ year dataset that can expand evidence on the role of residential contexts in impacting comprehensive cognitive health outcomes within a national, multi-ethnic cohort.

PI_NAMEs: HIRSCH, JANA ARIEL (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: abeta deposition;Address;adjudication;Affect;African American;Age;Alzheimer's disease related dementia;Alzheimer's disease risk;Biological Markers;Buffers;built environment;cardiovascular risk factor;Cerebrovascular Disorders;Characteristics;Clinical;clinically relevant;Code;Cognition;Cognitive;cognitive ability;cognitive performance;cohort;Collection;Communities;coping;Data;Data Set;Dementia;dementia risk;design;Diabetes Mellitus;Digit structure;Disparity;disparity reduction;Education;Environment;Ethnic Origin;Ethnic Population;Exclusion;executive function;experience;Face;Food;Gender;Goals;Health;healthy aging;Hispanic Populations;Impaired cognition;improved;Individual;Inequality;instrument;Intervention;Link;Longitudinal cohort;Low income;Maintenance;Measures;mild cognitive impairment;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;neighborhood association;Neighborhoods;Nerve Degeneration;nutrition;Obesity;older adult;Outcome;Pathology;Pathway interactions;Pattern;Physical activity;Physical environment;Play;Policies;Population;Population Heterogeneity;Prevalence;Process;processing speed;Race;racial disparity;racial minority;racial population;Recreation;remediation;Research;Research Personnel;Resources;Risk;Role;Safety;Sampling;Science;screening;Short-Term Memory;Shoulder;Sleep;social cohesion;social determinants;Social Environment;socioeconomic disparity;Socioeconomic Status;socioeconomics;stem;Surveys;Testing;theories;Time;walkability;Work

PROJECT_TITLE: Contribution of Longitudinal Neighborhood Determinants to Cognitive Health and Dementia Disparities within a Multi-Ethnic Cohort

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Pediatric;Prevention;Vaccine Related;Vector-Borne Diseases

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: Project Narrative Safe and efficacious vaccines for Rift Valley fever are not available for humans. We will characterize a novel live-attenuated candidate vaccine, termed RVax-1, in several key animal models and mosquitoes for the attenuation, immunogenicity, and protective efficacy.

PI_NAMEs: IKEGAMI, TETSURO  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Abortion Rates;Affect;Africa South of the Sahara;Animal Experiments;Animal Model;Animals;Area;Attenuated;Attenuated Vaccines;attenuation;Blindness;C57BL/6 Mouse;Category A pathogen;Cattle;Cells;Characteristics;Child;Classification;Clinical;Containment;Country;Culicidae;Disease;Disease Outbreaks;Dose;Egypt;Encephalitis;Ensure;Enzymes;experimental study;fetal;Fetus;Generations;Genes;Genetic Markers;Goals;Goat;Good Manufacturing Process;Health;Hemorrhage;Human;Immunity;immunogenic;immunogenicity;Infant;Intramuscular;Investigational Drugs;Kansas;Knowledge;Licensing;Liver;Madagascar;malformation;Medical;Midgut;Military Personnel;mosquito-borne;mouse model;Mus;mutant;National Institute of Allergy and Infectious Disease;Neonatal Mortality;neutralizing antibody;novel;Open Reading Frames;Phase I/II Trial;Phenotype;Placenta;Play;pre-clinical;preclinical evaluation;Predisposition;Pregnancy;pregnant;Pregnant sheep;Production;professional atmosphere;protective efficacy;prototype;Public Health;Qualifying;Quantitative Evaluations;Rattus;Recombinants;research clinical testing;reverse genetics;Rift Valley Fever;Rift Valley fever virus;Rodent;Rodent Model;Role;Route;Ruminants;Safety;Saudi Arabia;Sheep;sheep model;Silent Mutation;Sprague-Dawley Rats;Syndrome;Testing;Texas;Tissues;transmission process;United States National Institutes of Health;Universities;Update;Vaccinated;Vaccination;vaccine candidate;Vaccines;vector mosquito;Vero Cells;Vertical Transmission;Viral;Viremia;Virus;Virus Diseases;World Health Organization;Yemen;Zoonoses

PROJECT_TITLE: Safety and immunogenicity of a novel Rift Valley fever candidate vaccine, RVax-1

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative This research plan will design, fabricate, and test a replacement regenerative vein valve to treat patients with diseased valves that cause blood to pool in their legs. The valve is grown from a donor’s skin cells directly on a stent for minimally invasive delivery via a catheter and then decellularized for implantation into any patient without an immune response. Computer-aided design will be used to identify the optimal valve design, and after extensive bench-top testing, the valve will be tested in the iliac veins of sheep, then the FDA engaged regarding the clinical approval process.

PI_NAMEs: TRANQUILLO, ROBERT T (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Adult;Anatomy;Angiography;Animals;Anticoagulation;aortic valve;Biochemical;Biocompatible Materials;Biological Assay;Biomedical Engineering;Blood;Blood flow;calcification;Catheters;Cells;Cellularity;cGMP production;Chronic;Clinical;Closing Volume;Coagulation Process;commercialization;Compression Stocking;Computer Models;Computer-Aided Design;cost estimate;Cyclic GMP;deep vein;Dermal;design;Diameter;Dimensions;Disease;Drops;Endothelium;Ensure;expectation;fabrication;Failure;FDA approved;Fibrin;Fibroblasts;Gel;Geometry;Growth;Harvest;healing;Heart Valves;hemocompatibility;hemodynamics;Histology;Iliac Vein;Immune response;Immunohistochemistry;implantation;improved;In Vitro;in vitro testing;in vivo;Injections;Leg;Leg Ulcer;Legal patent;Light;manufacture;mechanical properties;meetings;Methods;minimally invasive;Modeling;Natural regeneration;nitinol;novel;Outcome;Papio;Patients;Performance;Periodicals;Phase;Phase I Clinical Trials;Phenotype;Physiologic pulse;Physiological;Positioning Attribute;Pre-Clinical Model;Preclinical Testing;pressure;Process;Prosthesis;Protocols documentation;Publications;Pulmonary artery structure;Pulmonary valve structure;Reflux;regenerative;Regulatory Pathway;Research;Research Project Summaries;Sheep;Side;Sinus;Skin;Sleep;Stenosis;Stents;success;Surgical sutures;System;Technology;Testing;Time;Tissue Engineering;Tissues;Translations;Tricuspid valve structure;Tubular formation;ultrasound;Validation;Veins;Venous;Venous Insufficiency;Walking

PROJECT_TITLE: Biologically-engineered Transcatheter Vein Valve: Design Optimization and Preclinical Testing


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Pain Research;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative We will develop new high-resolution anatomical imaging methods that provide detailed biochemical information on G protein coupled receptor (GPCR) signaling in the brain. The methods will be useful for measuring changes in GPCR function that occur in response to chronic drug taking, chronic stress, or chronic pain. They will enable new discoveries that can accelerate the development of pharmacological interventions for substance use disorders.

PI_NAMEs: O'NEILL, PATRICK ROSS (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Acceleration;addiction;Agonist;anatomic imaging;Anatomy;Animal Behavior;Antibodies;Autoradiography;Behavior;Binding;Biochemical;biological adaptation to stress;Biological Assay;Biosensor;Biotin;Brain;Brain Diseases;cannabinoid receptor;cell type;Chronic;chronic pain;Chronic stress;Color;Complex;cryostat;Data;Development;drug of abuse;drug seeking behavior;Drug usage;Equipment;Exhibits;experimental study;Fc Receptor;Fluorescence;fluorescence microscope;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic;Goals;GTP-Binding Proteins;Heating;Image;imaging modality;Immunohistochemistry;In Situ;innovation;insight;interest;Intervention;laboratory equipment;Ligands;Ligation;Link;Location;Measurement;Measures;Mediating;Metabotropic Glutamate Receptors;Methods;Modeling;Modification;Molecular;Motivation;mu opioid receptors;Mus;National Institute of Drug Abuse;negative affect;neural circuit;Neuroanatomy;neuronal excitability;Neurosciences;neurotransmitter release;nonhuman primate;novel;novel therapeutics;Nucleotides;Opioid Receptor;opioid use disorder;optogenetics;Pain;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Play;Property;protein activation;Publishing;ratiometric;Rattus;Reagent;receptor;receptor coupling;receptor function;Resolution;response;Rewards;Role;Sensory;Signal Transduction;Specificity;Stress;Substance Use Disorder;success;Synaptic Transmission;System;temporal measurement;Testing;Therapeutic;Tissue Fixation;Tissues;tool;virtual;Withdrawal

PROJECT_TITLE: High Content Functional Neuroanatomy of Endogenous GPCRs


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Dental, Oral, and Craniofacial Disease

ORG_CITY: JACKSON

ORG_DEPT: CHEMISTRY

ORG_NAME: JACKSON STATE UNIVERSITY

ORG_STATE: MS

PHR: Project narrative This study aims to investigate the role of water in terms of content and structure in dental hard tissues using optimized Raman spectroscopy. The discoveries of this study may lead to a better understanding of how water contents vary during caries development or other dental issues such as mechanical degradation. Thus the study may impact the prevention and management of dental diseases.

PI_NAMEs: YANG, SHAN  (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: absorption;Aging;Biological;Biological Markers;Chemicals;Classification;clinical practice;Communities;demineralization;Dental;Dental caries;Dental Enamel;Dental Research;Dentin;detector;Development;Devices;Diagnosis;diagnostic value;Dryness;Evaluation;Exposure to;Failure;Fatigue;Fluorescence;Functional disorder;High temperature of physical object;Hydration status;infrared spectroscopy;insight;interest;Lesion;light scattering;Magnetism;Measurement;Measures;mechanical properties;Mechanics;Metals;Methods;microCT;Minerals;Noise;Normal tissue morphology;Nuclear;Nuclear Magnetic Resonance;Odontogenesis;Pathology;Performance;Pilot Projects;preference;Preparation;Prevention;Property;Publishing;Raman Spectrum Analysis;Reporting;Research;Role;Sampling;Scanning;Shapes;Signal Transduction;Spectrometry;Spottings;Structure;success;System;Testing;Time;Tissues;tool;Tooth Diseases;Tooth structure;Variant;Water

PROJECT_TITLE: Role of Water in Dental Hard Tissues


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: SAN DIEGO

ORG_NAME: ARIMA GENOMICS, INC.

PHR: Scalable single-cell workflow for multiomic analyses of chromatin interactions, accessibility, gene expression and cell surface proteins to unravel mechanisms of cellular diversity Arima Genomics Project Narrative Precise regulation of genes is essential for establishing cellular diversity and functionality throughout the human body, and mis-regulation of genes causes human disease. To regulate expression, cells utilize regulatory regions embedded within chromatin, as well as the physical interactions between regulatory regions and genes contained within the three-dimensional (3D) nuclear milieu of each cell. Most genomics assays to study 3D chromatin interactions, including ones developed by Arima, analyze samples in “bulk” – where measurements of chromatin interactions are averaged across all cells in the population, failing to capture the ever-important dynamic chromatin interaction landscape in each cell within a larger tissue or organ system. Lately, academic assays have been developed to analyze chromatin interactions in single cells, but these assays remain inefficient, and complex. Improved and standardized assays are critically needed. Via a self-funded phase-1 project, Arima has overcome these challenges to develop a kit-based solution for efficient mapping of chromatin interactions in single cells. To truly inform gene regulatory mechanisms, chromatin interactions cannot be studied in isolation – instead, it needs to be captured alongside regulatory and gene expression information. Building off the phase-1 kit, Arima proposes to develop a scalable kit-based solution for concurrently mapping all three modalities within individual cells. The development of our new single-cell multiomic solution aims to build new inroads for delineating mechanisms governing cell diversity and function in heterogeneous disease microenvironments, toward ultimately improving the human condition via enhanced discovery, diagnosis, and therapy.

PI_NAMEs: SCHMITT, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 3-Dimensional;Academia;Address;Adoption;Area;Bar Codes;Basic Science;Benchmarking;Biological;Biological Assay;Biology;Body System;Brain;Breast;Cell Separation;Cell Surface Proteins;cell type;Cells;Chemistry;Chromatin;Chromium;combinatorial;commercial prototype;commercialization;Communities;Complex;cost;Data;Data Analyses;Development;Diagnosis;Disease;DNA Sequence;drug discovery;Ensure;Environment;Feeds;Funding;Gene Expression;Gene Expression Regulation;Genes;Genome;genomic platform;Genomics;Health;Heterogeneity;Hippocampus;Human;Human body;human disease;improved;indexing;Individual;Informatics;innovation;insight;Learning;Letters;Libraries;Link;Malignant Breast Neoplasm;Malignant neoplasm of prostate;manufacture;Maps;Marketing;Measurement;Modality;Molecular Biology;Morphology;multiple omics;Mus;Neighborhoods;Nuclear;Nucleic Acid Regulatory Sequences;Organ;Organism;Output;Phase;Phenotype;Play;Population;Process;product development;Program Development;programs;Proliferating;prostration;protein expression;Protocols documentation;prototype;Publishing;Reaction;Reagent;Regulator Genes;Regulatory Element;Research;research and development;Research Personnel;Resolution;Role;Sales;Sampling;screening;Shipping;single cell ATAC-seq;single-cell RNA sequencing;Source;Standardization;success;symposium;Technology;Testing;Tissues;tool;Translating;Translational Research;Transposase;Validation;webinar;XCL1 gene


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Infectious Diseases;Microbiome;Urologic Diseases

PHR: PROJECT NARRATIVE This proposal seeks to understand the impact and mechanisms by which trained immunity, adaptive immunity, and gut dysbiosis impact uropathogenic E coli (UPEC) infection of the bladder and reservoir formation in the gastrointestinal tract (GIT) using: i) advanced mouse models of urinary tract infection (UTI); ii) GI colonization; and iii) a primary urothelial cell culture system. In this way, this proposal investigates: i) the impact of epigenetic remodeling of the bladder urothelium on inflammation dynamics and disease outcome upon UPEC infection; ii) the mechanisms by which adaptive immunity modulates susceptibility to recurrent infection; and iii) the mechanisms by which the gut mucosa restricts UPEC colonization. This is particularly important since UTls are very common and highly recurrent, and increasingly caused by antibiotic resistant strains.

PI_NAMEs: COLONNA, MARCO  (contact);HULTGREN, SCOTT J.

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Acute;adaptive immune response;adaptive immunity;Adult women;Antibiotic Resistance;Antibiotic Therapy;Antibody-mediated protection;Antigens;antimicrobial;Apoptosis;ATAC-seq;B-Cell Activation;B-Lymphocytes;Bacteria;Bacterial Infections;Binding;Binding Proteins;bisulfite sequencing;Bladder;Bladder mucosa;Bladder Urothelium;C3H/HeN Mouse;CD8-Positive T-Lymphocytes;Cell Culture System;Cell Line;Cell Separation;Cells;chromatin modification;Chronic;chronic infection;Cleavage Under Targets and Release Using Nuclease;Clostridium difficile;Complex;cyclooxygenase 2;cytokine;Data Analyses;Data Set;Defense Mechanisms;Disease;Disease Outcome;DNA Methylation;Dose;draining lymph node;dysbiosis;Enzymes;Epigenetic Process;epithelial stem cell;Epithelium;Escherichia coli Infections;experience;Exposure to;extracellular;Female;Functional disorder;Future;Gastrointestinal tract structure;Gene Expression;Genes;gut colonization;gut dysbiosis;gut homeostasis;gut microbiota;Gut Mucosa;Health;histone modification;Immune;immune function;Immune response;Immune System Diseases;Immunity;immunopathology;imprint;Infection;Infective cystitis;Inflammation;Inflammatory;Inflammatory Response;Inherited;inhibitor;interleukin-22;Lead;Lymphoid Cell;Medical;Memory;methylation pattern;Microbe;microbial;microbiome;microbiota;microbiota composition;Modeling;Modification;Morphology;Mouse Cell Line;mouse model;Mouse Strains;Mucins;Mucosal Immunity;Mucous body substance;Mucous Membrane;Mus;Nature;neutrophil;new therapeutic target;Opportunistic Infections;Oral;Organism;Outcome;pathogen;Pathway interactions;Patients;Phenotype;Predisposition;prevent;Primary Cell Cultures;Process;Production;programs;Prostaglandins;Protein Deficiency;Recording of previous events;Recurrence;recurrent infection;Resistance;resistant strain;Resolution;response;Risk;Risk Factors;Role;Shapes;Signal Transduction;stem cells;Streptomycin;therapy development;TNF gene;Training;trait;United States;Urinary tract infection;Urine;Uropathogenic E. coli;Urothelial Cell;Urothelium;Visit;Volatile Fatty Acids;whole genome;Woman;Work;Writing

PROJECT_TITLE: Mucosal Immune Defense Mechanisms of the Urinary Bladder

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: RICHMOND

ORG_DEPT: PSYCHIATRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Project Narrative Alcohol consumption (alcohol quantity x frequency/AQF), Alcohol Use Disorders (AUDs) and posttraumatic stress disorder (PTSD) often co-occur, and there is emerging evidence that shared genetic risk may partially account for the high rates of this co-occurrence. This project seeks to clarify the shared molecular genetic underpinnings of the PTSD-AQF/AUD co-occurrence, while testing two key laboratory-based phenotypes (i.e., distress tolerance and anxiety sensitivity) as potential predictors, and socioeconomic status and social support as moderators of genetic effects. This K01 award will provide the candidate with the necessary training to become an independent, federally-funded investigator in the intersection of traumatic stress-related outcomes, laboratory-based paradigms, and psychiatric and statistical genetics.

PI_NAMEs: BOUNTRESS, KAITLIN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Alcohol consumption;Alcohol Phenotype;alcohol risk;alcohol use disorder;Alcohols;anxiety sensitivity;anxiety symptoms;Behavioral;Big Data;biobank;Candidate Disease Gene;Clinical;Cognitive;comorbidity;cost;Data;Data Analyses;design;Development;Disease;distress tolerance;emotion regulation;Environment;Epidemiologic Factors;Etiology;experimental study;Frequencies;Funding;Generations;Genes;Genetic;genetic association;Genetic Risk;genome wide association study;genomic data;Genomics;Goals;improved;intervention program;Laboratories;Laboratory Study;Linkage Disequilibrium;Longitudinal Studies;low socioeconomic status;Maps;Measures;Mendelian randomization;Mental Health;Mentored Research Scientist Development Award;Mentorship;Methodology;Methods;Molecular;Molecular Genetics;molecular scale;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;negative emotional state;non-genomic;novel;Outcome;Pathway interactions;Patient Self-Report;Phenotype;pleiotropism;polygenic risk score;Post-Traumatic Stress Disorders;Prevention;Process;Psyche structure;Psychiatric epidemiology;psychiatric genomics;Psychophysiology;recruit;Research;Research Personnel;Research Priority;Risk;Risk Factors;risk prediction;risk sharing;Science;social;social epidemiology;Social support;Socioeconomic Status;Stress;Testing;Time;Training;trait;Translating;Translational Research;Trauma;traumatic event;traumatic stress;Twin Multiple Birth;university student;Work

PROJECT_TITLE: Alcohol Use Phenotypes and Posttraumatic Stress Disorder: Investigating Shared Genetic, Behavioral, and Psychophysiological Risk Factors

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Alzheimer’s disease (AD) and AD-related dementias (ADRD) are an increasingly important public health issue with the rapid aging of the population. Early detection of individuals prior to overt or irreversible symptoms is an important step in managing this growing crisis. This preclinical stage represents an ideal time for targeted prevention and therapeutics, when available.

PI_NAMEs: GIFFORD, KATHERINE A.;JEFFERSON, ANGELA L. (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Address;Adult;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloidosis;Automobile Driving;Biological Markers;biomarker validation;Brain;brain magnetic resonance imaging;Cerebral small vessel disease;Cerebrospinal Fluid;Cerebrum;Characteristics;Clinical;Cognition;Cognitive;cohort;Collection;Complex;cost effective;Cost utility;Data;Dementia;dementia risk;Deposition;Depressed mood;detection method;Device or Instrument Development;Disease;Disease Marker;early detection biomarkers;Early Diagnosis;Early identification;Enrollment;Etiology;feature selection;Female;follow-up;Heterogeneity;high dimensionality;Impaired cognition;improved;Incidence;Individual;innovation;Interview;Investigation;Laboratories;Longitudinal cohort;Longitudinal Studies;Measurable;Measures;Medical History;Memory;Methods;Microvascular Dysfunction;Modeling;Modification;multimodality;Nerve Degeneration;neuroimaging;neuropathology;neuropsychiatric symptom;neuropsychiatry;Neuropsychology;novel;older adult;Outcome;Participant;Pathologic;Pathologic Processes;Pathology;Pathway interactions;Patient Self-Report;Performance;Population;pre-clinical;Prevention;Procedures;Process;prospective;Prospective cohort;Protocols documentation;Public Health;Questionnaires;Research;Research Personnel;Resources;Risk;sex;Specificity;Spinal Puncture;Symptoms;tau aggregation;tau Proteins;Testing;Therapeutic;Thinking;Time;tool;tool development;Training;Validation;Variant;white matter injury;Work

PROJECT_TITLE: Subjective Cognitive Decline in OIder Adults

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Emerging Infectious Diseases;Genetics;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PHR: EBV lytic replication is fundamental for the spread of the virus within and between hosts and it is a precursor to the development of EBV associated cancers and autoimmune diseases. In this application, we will test our hypothesis that EBV replication interacts with the host cell transcriptome in novel ways that facilitate the spread of the virus within the host, contributing to EBV associated diseases.

PI_NAMEs: FLEMINGTON, ERIK K (contact)

PROJECT_TERMS: Address;AIDS population;Alternative Splicing;arm;Autoimmune Diseases;Automobile Driving;cell growth regulation;Cell Nucleus;Cells;Chemicals;co-infection;Cues;Cytoplasm;Dedications;Development;DNA Polymerase II;DNA Polymerase III;DNA Tumor Viruses;Down-Regulation;EBV-associated disease;Elements;Epstein-Barr Virus-Related Lymphoma;Epstein-Barr Virus-Related Malignant Neoplasm;Event;Exhibits;exon skipping;gammaherpesvirus;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;Herpesviridae;high volume manufacturing;HIV;HIV/AIDS;Hodgkin Disease;Human Herpesvirus 4;Human Herpesvirus 8;Human Pathology;Individual;insight;Link;Lytic;lytic replication;malignant stomach neoplasm;Mediating;Messenger RNA;Metabolism;Modeling;Mus;Nasopharynx Carcinoma;Non-Hodgkin's Lymphoma;novel;Nuclear;Nuclear Structure;nuclease;Pathway interactions;Population;Predisposition;Process;Production;programs;promoter;Protein Biosynthesis;Proteins;Resources;response;RNA;RNA Decay;RNA Degradation;RNA Splicing;RNA-Binding Proteins;Role;Site;Specificity;Spliceosomes;Stimulus;Structural Protein;Testing;Transcript;Transcriptional Activation;transcriptome;Translations;Untranslated RNA;Viral;Viral Genes;Viral Proteins;viral RNA;Viral Structural Proteins;Virion;Virus;virus host interaction;Virus Latency;Virus Replication

PROJECT_TITLE: Programmed splicing derangement as new EBV host cell shut-off mechanism

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

PHR: Development of small molecule inhibitors of metabolic enzymes as broad spectrum anthelmintic drugs Project Narrative Parasitic intestinal nematodes, notably hookworms, roundworm and whipworms, infect more than two billion people and are a leading cause of human morbidity and the maintenance of poverty. The main goal of this project is to conduct drug discovery and development of novel small molecule drugs that selectively target nematode metabolic enzymes for control of these devastating parasites, and to reduce their associated morbidity and mortality. Compounds targeting conserved pan-phylum metabolic enzymes, essential for their survival, will be optimized for increased potency, nematode selectivity and in vivo efficacy with broad spectrum activity. 2

PI_NAMEs: JANETKA, JAMES W;MITREVA, MAKEDONKA  (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Acceleration;Active Sites;Address;Adult;Affect;Affinity;Ancylostoma (genus);Animal Model;Anthelmintics;Area;Basic Science;bioaccumulation;Biochemical;Biochemical Pathway;Bioinformatics;Biological;Biological Assay;burden of illness;Carnitine;Clinical;clinical candidate;Consumption;Data;Databases;design;Development;Dimensions;Docking;Drug Design;drug development;drug discovery;Drug Kinetics;Drug resistance;Drug Targeting;Enzyme Inhibition;Enzyme Inhibitor Drugs;Enzymes;Evaluation;experience;Formulation;FRAP1 gene;Funding;Gene Expression Profiling;Generations;Genes;Genome;Genomics;Goals;Hamsters;Homologous Gene;Homology Modeling;Hookworms;Human;human morbidity;improved;In Vitro;in vivo;in vivo evaluation;Infection;inhibitor;innovation;interdisciplinary approach;Intervention;Intestines;knock-down;Knowledge;Label;Lead;lead optimization;Life;Maintenance;Measures;Metabolic;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Mus;mutant;Necator americanus;Nematoda;Nematode infections;novel;novel therapeutics;Orthologous Gene;Parasites;Parasitic nematode;parasitism;Parasitology;pathogen;Pathway interactions;Penetration;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;phosphoric diester hydrolase;Phosphotransferases;Phylogeny;PIK3CG gene;Poverty;pre-clinical;Property;Proteins;public health priorities;rational design;Recombinants;Research;Rodent Model;Roentgen Rays;screening;Series;small molecule;small molecule inhibitor;small molecule therapeutics;species difference;Structure;Structure-Activity Relationship;Systems Biology;Taxonomy;Techniques;Testing;Time;Toxic effect;Transferase;Translational Research;Trichuris;United States National Institutes of Health;Work

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Chronic obstructive pulmonary disease (COPD) affects approximately 16% of the veteran population. COPD is the fourth most prevalent disease in the VA population and one of the most costly to the VA health care system. Over 500,000 service-connected respiratory disabilities have been diagnosed in veterans and 6.5% of all Gulf War service-connected disabilities are respiratory system related. Operation Enduring Freedom and Operation Iraqi Freedom Veterans have been exposed to chemicals known to cause acute and chronic respiratory conditions including CARC paint and chromium dust. Other veterans have experienced acute lung failure from blast injury, smoke inhalation, or COVID-19. Over 2.3 million veterans reported having some form of “lung trouble” in the 2001 National Survey of Veterans. This project has the potential to revolutionize the rehabilitation of Veterans suffering from lung disease through the development of a truly portable, biocompatible, artificial lung prothesis.

PI_NAMEs: POTKAY, JOSEPH ALLEN (contact)

PROJECT_TERMS: 3-Dimensional;3D Print;Acute;Address;Adult;Affect;Air;Animal Model;Animal Testing;Animals;Area;artificial lung;biomaterial compatibility;Biomimetics;Blast Injuries;Blood;Blood flow;blood fractionation;Blood Volume;Carbon Dioxide;Cattle;Chemicals;Chromium;Chronic;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;clinical application;cost;cost effective;COVID-19;Custom;design;Development;Device Removal;Devices;Diagnosis;Diameter;disability;Disease;Dust;Engineering;Excision;Exhibits;experience;Experimental Designs;Exposure to;fabrication;first-in-human;Freedom;Gases;Geometry;Goals;Gulf War;Healthcare Systems;hemocompatibility;Human;improved;In Vitro;in vitro testing;in vivo;in vivo evaluation;innovation;Investigation;Laboratories;Length;Liquid substance;Lung;Lung Diseases;lung failure;manufacture;Measures;Mechanics;Membrane;Methods;Microfabrication;Microfluidic Microchips;Microfluidics;military veteran;Modeling;Nature;operation;Paint;Patients;Performance;Perfusion;Permeability;Physiologic arteriovenous anastomosis;Plant Resins;Polymers;Population;portability;Positioning Attribute;pressure;Printing;Procedures;Production;pulmonary rehabilitation;reduce symptoms;Rehabilitation therapy;Reporting;Research Proposals;Resolution;respiratory;Respiratory System;scale up;Services;sheep model;Side;Siloxanes;smoke inhalation;Surface;Surveys;System;Techniques;Technology;technology development;Testing;Thick;Time;Toxic effect;Toxicity Tests;two-dimensional;usability;Veterans;wearable device

PROJECT_TITLE: 3D Printed Microfluidic Artificial Lung for Veteran Rehabilitation

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: There is a rapidly increasing clinical demand for bone grafting materials for use in osseous regeneration and repair surgeries. Although autografts (from self) and allografts (cadaver) are the currently preferred options, each has its own drawbacks, including limited resources. A potential solution to overcome this graft material shortage is to develop equivalent engineered bone substitutes. This study is designed to test the efficacy of one such bone substitute, a fluoridated calcium phosphate-based bioceramic. In our initial studies, fluorapatite was shown to enhance in vitro differentiation of osteoblasts and stem cells into the osteogenic lineage, but more importantly, resulted in ~90% new bone formation in both, in vivo rat and pig models. The proposed study is designed to develop an autograft-like bone scaffold by incorporating a FA scaffold with a recipient’s own stromal vascular fraction cells—derived from a recipient’s fat tissue—to fill critical-size bone defects. If proven, this combination approach may become “off-the-shelf” autograft-like bone scaffolds for orthopedic and dental applications.

PI_NAMEs: AGARWAL, JAYANT PRASAD (contact)

PROJECT_TERMS: Acceleration;adipose derived stem cell;Adipose tissue;allogenic bone transplantation;Allografting;American;Animals;Apatites;aspirate;Autologous;Autologous Transplantation;Autopsy;Biocompatible Materials;Biomedical Engineering;Blood Vessels;bone;bone engineering;bone reconstruction;Bone Regeneration;bone repair;bone scaffold;Bone Substitutes;Bone Tissue;Bone Transplantation;Cadaver;calcium phosphate;Cell Fraction;cell type;Cells;Clinical;clinical application;clinical material;Combined Modality Therapy;cost;Country;Data;Defect;density;Dental;design;Development;Diameter;differentiation in vitro;Distal;efficacy testing;Evaluation;experience;Family suidae;Fatty acid glycerol esters;FDA approved;Female;Femur;fluorapatite;Fracture;Generations;Grant;Growth Factor;Harvest;Health;Healthcare Systems;Human;Hydroxyapatites;ilium;Implant;improved;in vivo;Intramedullary Nailing;Knowledge;Left;male;Measures;Mechanics;Messenger RNA;microCT;Military Personnel;Modeling;Natural regeneration;novel;Operative Surgical Procedures;Orthopedics;osteoblast differentiation;Osteogenesis;osteogenic;Outcome Measure;Patients;Phosphoproteins;porcine model;primary outcome;Process;Publishing;Quality of life;Rattus;reconstruction;Reconstructive Surgical Procedures;repaired;Resources;Risk;scaffold;secondary outcome;Sheep;Signal Transduction;Site;skeletal;Skeleton;Source;Stainless Steel;stem cell population;stem cells;substantia spongiosa;Surface;Techniques;Testing;tibia;Tibial Fractures;Time;Tissue Harvesting;Tissues;transcriptome sequencing;Trauma;United States;Veterans;Water fluoridation;Weight-Bearing state;X-Ray Computed Tomography

PROJECT_TITLE: Fluoridated scaffolds for the treatment of critical-size bone defects

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


PHR: Project Narrative  Enteric viruses are highly infectious human pathogens that cause significant morbidity and mortality worldwide and rotavirus infection alone leads to an annual death of 215,000 people. The proposed study on the molecular interactions between an interferon-stimulated gene SAMD9 and rotavirus-encoded NSP1 will provide new information on host inhibition of enteric virus replication and viral counteraction strategies. The long-term objective of this study is to facilitate the rational design of efficacious interferon-based therapeutics and the development of an optimized, third-generation rotavirus vaccine, thereby reducing the overall global disease burden. !

PI_NAMEs: DING, SIYUAN  (contact)

PROJECT_TERMS: Accountability;Adsorption;antagonist;Anti-viral Response;attenuation;Binding;Binding Proteins;Biochemistry;Biological Assay;Biological Models;Biology;burden of illness;CEB1 Gene;cell type;Cells;Cessation of life;Child;Chronic diarrhea;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Complex;crosslink;Data;Data Set;Development;Diarrhea;Disease;Early Endosome;Ectopic Expression;Elongation Factor;Endocytosis;Enteral;enteric virus infection;Epithelial Cells;Epithelium;Expression Library;fluorophore;Foundations;gain of function;Gastroenteritis;Generations;Genes;Genetic Transcription;Goals;House mice;Human;human pathogen;Immune Evasion;Immunoprecipitation;improved;In Vitro;in vivo;Individual;Infant;Integration Host Factors;Interferons;intestinal epithelium;Intestines;Knock-out;Knowledge;Label;Letters;major vault protein;Maps;Mass Spectrum Analysis;Mediating;Medical;Messenger RNA;MIRAGE syndrome;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;Mucous Membrane;Mutagenesis;mutant;Mutation;Neonatal;Nonstructural Protein;novel;Organoids;Outcome;overexpression;Patients;Penetration;Persons;Physiological;Poxviridae;Predisposition;prevent;Process;Production;Proteins;Proteomics;Protocols documentation;rational design;Rattus;response;reverse genetics;RNA;Role;Rotavirus;Rotavirus Infections;Rotavirus Vaccines;SAM Domain;screening;Severities;Side;Signal Transduction;Site-Directed Mutagenesis;Small Interfering RNA;Small Intestines;Structure;suckling;Surface;Symptoms;System;Testing;Therapeutic;Therapeutic Intervention;ubiquitin-protein ligase;vaccine candidate;Viral;Viral Antigens;Viral Pathogenesis;viral RNA;Virus;Virus Diseases;Virus Replication;Vomiting

PROJECT_TITLE: Interferon-Stimulated Gene Inhibition of Rotavirus Replication and Viral Antagonism

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PI_NAMEs: ZHENG, HUI  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Adult;Age;age related;Aging;Alzheimer's Disease;Atlases;Autophagocytosis;biological adaptation to stress;Biological Process;Biological Response Modifier Therapy;Biology;Brain;brain health;Cell Nucleus;Cell Physiology;Characteristics;Collaborations;combat;Communication;Data;Degenerative Disorder;detection of nutrient;Etiology;functional decline;Functional disorder;gene network;genetic risk factor;Genetic Transcription;Goals;Hippocampus;Histones;Homeostasis;hyperphosphorylated tau;Image;Impairment;in vivo;insight;interest;Knock-in Mouse;Lysosomes;Measures;Metabolism;metabolome;metabolomics;Modeling;Modification;Molecular;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurons;Nuclear Translocation;Online Systems;Organelles;Output;Pathway interactions;Pattern;Positioning Attribute;Post-Translational Modification Site;Post-Translational Protein Processing;preservation;programs;Property;protein aggregation;Proteome;Proteomics;Regulation;Regulatory Pathway;Research Support;Risk Factors;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Specificity;Stress;tau Proteins;Tauopathies;Technology;Testing;therapeutic target;Time;tool;Transcriptional Activation;transcriptome;vacuolar H+-ATPase

PROJECT_TITLE: Lysosome Regulation and Signaling in Aging and Alzheimer's Disease


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative The proposed research will investigate the mechanism of action of a frequently mutated tumor suppressor in breast cancer. Understanding functions and mechanisms of action of a frequently mutated human cancer driver will greatly advance our knowledge of the causes of human cancer and provide foundations for developing targeted cancer therapies.

PI_NAMEs: GUO, WENJUN  (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: Area;Breast Cancer Cell;Breast Cancer gene;Breast Epithelial Cells;cancer cell;Cancer Etiology;cancer genome;cancer therapy;cancer type;Carcinoma;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;CRISPR/Cas technology;Data;Development;Endocrine;Enzymes;Epigenetic Process;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Experimental Models;Foundations;Gene Deletion;Gene Expression Regulation;Gene Proteins;Genetic;genome editing;Goals;histone methyltransferase;Histones;Homeostasis;hormone therapy;Human;In Vitro;in vivo;Induced Mutation;innovation;Knock-in Mouse;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;mammary epithelium;Mammary Gland Parenchyma;Mammary Tumorigenesis;Mesenchymal;Methyltransferase;Modeling;Molecular;Multipotent Stem Cells;mutant;Mutate;Mutation;Neoplasm Metastasis;novel;Oncogene Activation;Oncogenic;Pathogenesis;PIK3CG gene;Play;Point Mutation;Property;Protein Truncation;Research;Resistance;Role;Somatic Mutation;stem cell differentiation;stem cell expansion;stem cells;stem-like cell;Stimulus;targeted cancer therapy;Technology;Testing;Therapeutic;therapy resistant;Tissues;tumor;tumor initiation;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;tumorigenesis

PROJECT_TITLE: Role of the histone modifier MLL3 mutation in breast cancer cell plasticity

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]