NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: PSYCHIATRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: PROJECT NARRATIVE Despite psychoeducational efforts about the potential consequences of drug use, relapse remains the modal outcome among treatment-engaged individuals with opioid use disorder (OUD).This clinical observation indicates a need for better understanding how undesirable information about drug use is evaluated and incorporated into patient’s beliefs about personal risk. Combining neuroimaging and real-world experience sampling, I will test whether individuals with OUD hold domain-specific optimistic beliefs about drug use in a way that can uniquely inform future efforts to develop more robust psychoeducational interventions for OUD.

PI_NAMEs: ALVAREZ, EMMANUEL EDUARDO (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: addiction;Address;Affect;Affective;Area;base;Behavior;behavioral study;Belief;Brain;Clinical;Cognitive;cognitive neuroscience;cognitive process;Computer Models;Corpus striatum structure;Decision Making;design;drug maintenance;Drug usage;Ecological momentary assessment;Enrollment;Event;expectation;experience;Fracture;Functional Magnetic Resonance Imaging;Future;Human;Individual;Inferior frontal gyrus;Intervention;Knowledge;laboratory experiment;Life;Literature;Magnetic Resonance Imaging;Maintenance;Measures;Mental Depression;Methodology;Methods;Modality;Modeling;Moods;neural;neural circuit;neural correlate;neuroimaging;neuromechanism;Neurosciences;news;non-drug;novel;Opioid;opioid epidemic;opioid use;opioid use disorder;opioid user;optimism;Outcome;Overdose;Participant;patient engagement;Patient Self-Report;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;Population;Positioning Attribute;pre-doctoral;Preventive;Process;programs;psychoeducation;psychoeducational intervention;psychologic;Psychopathology;Public Health;Relapse;Research;response;Risk;risk mitigation;Role;Sampling;Scientist;Statistical Models;Techniques;Testing;Time;tool;Training;Translational Research;Update;Ventral Striatum;Work

PROJECT_TITLE: Characterizing the formation and maintenance of drug-biased beliefs in opioid use disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Phosphoethanolamine (PEA) transferases are integral membrane bacterial enzymes that modify lipid A by PEA attachment, consequently interfering with the ability of polymyxin drugs to electrostatically interact with lipid A and disrupt the outer membrane. The recent discovery of a plasmid-encoded PEA transferase, known as the first variant of mobilized colistin resistance (MCR-1), entails the potentially rapid spread of polymyxin resistance worldwide and between bacterial strains through horizontal gene transfer. This project aims to elucidate the molecular mechanism by which MCR-1 binds its donor substrate, phosphatidylethanolamine (PE), and transfers the positively charged phosphoethanolamine (PEA) intermediate to its negatively charged acceptor substrate, lipid A, on the inner membrane of Gram-negative bacteria, thereby conferring resistance to last-resort antibiotics.

PI_NAMEs: ZINKLE, ALLEN PETER (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Address;Animal Sources;Antibiotics;Bacteria;bacterial resistance;Binding;Binding Sites;Biochemical;Biological Assay;C-terminal;Cartoons;Catalysis;Cell Death;Cells;Charge;China;Colistin;colistin resistance;Color;combat;Computer Models;Coupled;Cryoelectron Microscopy;Cytolysis;Data;density;Detergents;Drug Design;Electrostatics;Environment;enzyme structure;Enzymes;Escherichia coli;Family;Food;Genes;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Horizontal Gene Transfer;Human;improved;Infection;inorganic phosphate;insight;Left;Length;Lipid A;Lipids;Lipopolysaccharides;Livestock;Manuals;Maps;Mass Spectrum Analysis;Mediating;Membrane;Membrane Proteins;Modeling;Modification;Molecular;Molecular Conformation;molecular dynamics;monomer;Multi-Drug Resistance;Mutagenesis;N-terminal;nanodisk;Neisseria meningitidis;novel;particle;Pathogenicity;Perforation;periplasm;Pharmaceutical Preparations;Phosphatidylethanolamine;phosphoethanolamine;Plasmids;Polymyxin B;Polymyxin Resistance;Polymyxins;protein purification;protein structure;Public Health;reconstitution;Reporting;Resistance;resistance gene;Resolution;Risk;Scheme;Site;Structure;Time;Transferase;Transmembrane Domain;Variant;Work

PROJECT_TITLE: Mechanistic insights into lipid A modification by the phosphoethanolamine transferase MCR-1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Childhood Obesity;Clinical Research;Diabetes;Neurosciences;Nutrition;Obesity;Pediatric;Prevention;Sleep Research

ORG_CITY: Los Angeles

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE The work proposed here, will test for the first time whether poor sleep characteristics are associated with impaired MRI markers of hypothalamic signaling, a key brain region involved in glucose homeostasis, as well as increases in glucose and metabolic risk markers in children longitudinally. This work could lead to clinical trials to test for sleep modification as an important target for prevention of obesity and diabetes during childhood. This project is strongly aligned with the mission of NIDDK to understand: (1) Energy balance and physiological mechanisms modulating weight gain, loss and maintenance, and (2) Pathways that are involved in intermediary metabolism as they impact endocrine and metabolic diseases.

PI_NAMEs: PRATHAP,  SANDHYA  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Accelerometer;actigraphy;Age;Animal Model;Animals;Beta Cell;blood glucose regulation;Brain;brain magnetic resonance imaging;Brain region;career;Cell Physiology;Cerebrovascular Circulation;Characteristics;Child;Childhood;Childhood diabetes;Circadian desynchrony;Clinical Trials;cohort;Data;Development;Endocrine System Diseases;energy balance;Future;Gliosis;Glucose;Glucose Intolerance;Goals;Health;Homeostasis;Human;Hypothalamic structure;impaired glucose tolerance;Impairment;indexing;Inflammation;Inflammatory;insight;Insulin Resistance;insulin sensitivity;Intervention;Knowledge;Link;Longitudinal Studies;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maintenance;Measures;Mediating;Mentors;Mentorship;Metabolic;Metabolic Diseases;Metabolism;Mission;Modification;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;neuroimaging;Neurosecretory Systems;Nutrient;Obesity;obesity in children;obesity prevention;obesity risk;OGTT;Outcome;Pathway interactions;Physiological;poor sleep;Positioning Attribute;Postdoctoral Fellow;prospective;Research Personnel;response;Risk;Risk Marker;Rodent;Signal Transduction;Sleep;Sleep Deprivation;Testing;Time;tool;Training;training opportunity;Translating;translation to humans;translational approach;Weight Gain;Work;Youth

PROJECT_TITLE: Sleep Characteristics, Hypothalamic Signaling, and Metabolic Risk in Children - a Longitudinal Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-2 (O1)]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: Nashville

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative: Glioblastoma is a form of brain cancer with poor treatment options, an average survival time of 12-18 months post-diagnosis, and a five-year survival rate of less than 10%. Immunotherapy has shown promise for other cancer types, and we propose to design and test an innovative new immune activating RNA therapy for glioblastoma. We hypothesize that our therapy will generate a robust anti-tumor response without damaging the surrounding brain tissue.

PI_NAMEs: KWIATKOWSKI, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: adaptive immunity;Address;Agonist;Antigen-Presenting Cells;Antitumor Response;Area;Artificial nanoparticles;Binding;Biocompatible Materials;Bone Marrow;Brain;brain parenchyma;brain tissue;cancer immunotherapy;cancer type;Caring;CD8-Positive T-Lymphocytes;Cell Line;Cells;cellular targeting;Cervical lymph node group;Charge;Chemistry;Chemotherapy and/or radiation;Clinical;Clinical Trials;combat;Combined Modality Therapy;cytokine;Cytosol;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Dependence;design;Diagnosis;Double-Stranded RNA;Drug Delivery Systems;Effectiveness;efficacy evaluation;Endosomes;Engineering;Excision;experimental study;Flow Cytometry;Frequencies;Future;Genes;Glioblastoma;Growth;Immune;immune activation;immune cell infiltrate;immune checkpoint blockade;Immunocompetent;immunogenic;Immunologics;Immunophenotyping;immunoregulation;Immunotherapy;improved;In Vitro;in vitro activity;Infiltration;Inflammatory;Inflammatory Response;Injections;Innate Immune Response;innovation;insight;Interferon Type I;Interferons;Intracranial Neoplasms;intravital imaging;ITGAM gene;Knowledge;Learning;Life Expectancy;Local Therapy;Macrophage;Malignant neoplasm of brain;Malignant Neoplasms;Melanoma;Memory;Microglia;Modeling;mouse model;Mus;Myeloid Cells;Myeloid-derived suppressor cells;nanobodies;nanocarrier;nanoparticle;nanoparticle delivery;nanopolymer;Natural Immunity;Neuroimmune;neuroimmunology;Operative Surgical Procedures;Pathway interactions;Patients;Pattern recognition receptor;Phenotype;Phosphorylation;Polymers;Population;Pre-Clinical Model;prevent;Production;Property;recruit;Recurrence;Reporter;response;RNA;RNA delivery;Role;Route;secondary lymphoid organ;Solid Neoplasm;Stains;standard of care;stem;subcutaneous;Surface;Survival Rate;T cell infiltration;T cell response;T memory cell;T-Cell Activation;T-Cell Depletion;T-Lymphocyte;Testing;Therapeutic;therapeutic RNA;Time;Translations;Tretinoin;tripolyphosphate;tumor;Tumor Burden;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;uptake

PROJECT_TITLE: Engineering RIG-I Activating Nanoparticles for Glioblastoma Immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Substance Misuse

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative There an urgent need for new effective treatments to decrease the toll that alcohol use disorder takes on individuals and society. The experimental medication psilocybin has produced positive results in early-stage clinical trials using it to treat alcohol use disorder, and depression, but very little is known about how it might work to help people stop or decrease their drinking. In this study we will determine the effects of psilocybin on brain activity related to alcohol craving and negative emotion, and test whether these effects contribute to the therapeutic benefits of psilocybin.

PI_NAMEs: BOGENSCHUTZ, MICHAEL PARKS (contact)

PROGRAM_OFFICER_NAME: SENEVIRATNE, CHAMINDI

PROJECT_TERMS: Aftercare;Agonist;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol cue;alcohol response;alcohol use disorder;Animal Model;antidepressant effect;Anxiety;anxiety symptoms;Behavioral;Biological Markers;blood oxygenation level dependent response;Brain;Characteristics;Chronic stress;Clinical;Clinical Research;Control Groups;Corpus striatum structure;craving;Data;depression model;depressive symptoms;design;Diagnostic;Dose;Double-Blind Method;drinking;drinking behavior;effective therapy;emotion regulation;Emotional;emotional stimulus;Emotions;executive function;Exhibits;Expectancy;Functional Magnetic Resonance Imaging;Hallucinogens;Heavy Drinking;HTR2A gene;improved;incentive salience;Individual;interest;Intervention;Life;Machine Learning;Major Depressive Disorder;Malignant Neoplasms;Measures;Mental Depression;model design;Modeling;Moods;negative affect;neural;neuromechanism;Neuropsychology;neuroregulation;new therapeutic target;Outcome;Participant;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Phase I Clinical Trials;Phenotype;Pilot Projects;Placebos;pre-clinical research;Prediction of Response to Therapy;Psilocybin;Publications;Publishing;Questionnaires;Randomized;Randomized, Controlled Trials;Relapse;Research;Residential Treatment;response;Rest;ROC Curve;Rodent Model;Sampling;Serum;sobriety;Societies;Specific qualifier value;Statistical Methods;Stimulus;Supportive care;Testing;Therapeutic;Time;Treatment outcome;Visual;visual stimulus;Work

PROJECT_TITLE: Neural mechanisms of psilocybin-assisted treatment for alcohol use disorder.

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Microbiome;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: TAMPA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Many aspects of age-related cognitive decline, Alzheimer’s disease (AD), and its related dementia (ADRD) start several years before the full symptoms are diagnosed, however, markers to early predict them are limited. Here, we aim to establish stool and blood-based miRNA biomarkers diagnosing age-related cognitive decline and ADRD- debilitating, costly, and non-curable public health problems in older adults. The outcomes of this study will establish proof-of-concept that can be validated in large clinical studies, fulfilling the R21 application objective and perfectly aligning with the goals and mandate of NIA supported research.

PI_NAMEs: MASTERNAK, MICHAL MATEUSZ;YADAV, HARIOM  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Abeta clearance;Address;Affect;Age;age related;Age related pathologies;Age Years;Age-associated memory impairment;Aging;aging population;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Ancillary Study;Anus;Binding;Blood;Blood Circulation;blood-brain barrier crossing;Brain;brain cell;brain health;career;Cause of Death;Cell Aging;Cell Compartmentation;Cell Physiology;cell type;Cells;circulating biomarkers;Circulation;Clinical Research;Cognitive;cost;cost effective;Data;Dementia;Development;Diagnosis;Disease;Distant;Dyes;Endosomes;enema administration;Epigenetic Process;exosome;familial Alzheimer disease;fecal transplantation;Feces;Gene Expression;Genes;Genetic Transcription;Goals;gut bacteria;gut microbiome;gut microbiota;gut-brain axis;human old age (65+);Impaired cognition;Individual;Intravenous;Label;Link;Literature;Measures;Mediating;Membrane Lipids;microbial;microbiome;microbiome research;microbiome signature;microbiota;microRNA biomarkers;MicroRNAs;mild cognitive impairment;Multi-site clinical study;multidisciplinary;Neurons;neurotoxicity;next generation sequencing;novel;older adult;Older Population;Outcome Study;Participant;Pathogenesis;Pathway interactions;Peripheral;Plasma;Play;Prevalence;Prevention;Prognosis;programs;prospective;Proteins;Public Health;recruit;Research Support;Resources;response;Risk;risk prediction;Role;Route;Sampling;single-cell RNA sequencing;Sorting;Symptoms;Synapses;Testing;Tissues;Tracer;Travel;Vesicle

PROJECT_TITLE: miRNAs in the gut-brain axis to predict the risk of cognitive decline in older adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-D (02)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: WORCESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative: Nearly 1 in 3 people are infected with M. tuberculosis worldwide and roughly 2 million people die annually from TB. Evidence has shown that Mtb metabolism is linked to Mtb immune and antibiotic tolerance. This proposal seeks to ascertain how glutamine starvation and metabolic disruption impacts Mtb antibiotic tolerance during infection.

PI_NAMEs: WILLIAMS, JOHN TISON (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Acclimatization;Animal Model;Antibiotic Resistance;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Bacteria;bacterial genetics;Biological Availability;Cause of Death;Cell Line;Cell Separation;cell type;Cells;Cessation of life;Chemicals;Coupled;Data;Defect;drug efficacy;efficacious treatment;Engineering;Environment;Evaluation;experimental study;Exposure to;Failure;Genes;Genetic;genetic approach;Genetic Engineering;Genetic Screening;Glutamine;Goals;Growth;Heterogeneity;Immune;immune activation;Immune Tolerance;Immunologic Factors;improved;in vivo;Infection;Link;Lung infections;Macrophage;Metabolic;Metabolic Clearance Rate;Metabolism;Methods;Modeling;mouse model;Mus;mutant;Mycobacterium tuberculosis;Myeloid Cells;Nitrogen;novel;novel therapeutic intervention;Nutrient;Outcome;pathogen;Pathway interactions;Patients;Persons;Phagocytes;Phagosomes;Phenotype;Population;Predisposition;pressure;prevent;Public Health;Reactive Nitrogen Species;Reactive Oxygen Species;Regimen;Relapse;Research;Research Personnel;response;Role;Scientist;Series;single-cell RNA sequencing;skills;standard of care;Starvation;Sterilization;Techniques;Testing;Therapeutic;Time;Training;Translating;Treatment outcome;tuberculosis chemotherapy

PROJECT_TITLE: Glutamine Starvation as a Means to Enhance Antibiotic Efficacy against M. tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Acute myeloid leukemia (AML) remains a devastating disease with poor prognosis. This project will establish the RNA helicase DDX6 as a novel potential therapeutic target in AML by establishing it as a specific AML dependency and providing mechanistic insights into the molecular mechanisms underlying this dependency. We expect that the results from our studies will guide the development of targeted, precision therapies against AML.

PI_NAMEs: KODALI, SRIKANTH  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Acceleration;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;adult leukemia;Affect;Attenuated;Binding;Cell Maintenance;Cells;chemotherapy;Child;Childhood Leukemia;Clustered Regularly Interspaced Short Palindromic Repeats;conditional knockout;CRISPR screen;Cytoplasm;Cytoplasmic Granules;Data;Dependence;derepression;Development;differentiation in vitro;Disease;Dropout;Drug Targeting;effective therapy;experimental study;Genetic Predisposition to Disease;genome-wide;Goals;Growth;helicase;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic stem cells;Homeostasis;Human;Human body;In Vitro;in vivo;insight;KDM5B gene;Knowledge;leukemia;Leukemic Cell;leukemogenesis;Link;Maintenance;Malignant - descriptor;Maps;Mediating;Messenger RNA;Molecular;mouse model;mRNA Translation;Mus;mutant;Mutation;Myeloid Progenitor Cells;novel;novel therapeutic intervention;Oncogenic;overexpression;Patients;posttranscriptional;precision drugs;Precision therapeutics;prevent;Prognosis;protein expression;Proteome;Research;Ribonucleoproteins;RNA;RNA Helicase;RNA Processing;Role;Screening Result;self-renewal;stem cells;Survival Rate;targeted treatment;Testing;therapeutic target;Tissues;TRAF6 gene;Transcript;transcriptome;Translational Derepression;Translational Repression;Translations;translatome;Transplantation;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;United States;Work

PROJECT_TITLE: Targeting the RNA helicase DDX6 in acute myeloid leukemia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09A-R (20)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Drug associated cues are powerful drivers of craving and relapse in people with substance use disorder. Contexts that contain reward-predictive cues often contain many other cues unrelated to reward. This proposal aims to determine how neuronal activity in the nucleus accumbens contributes to the learning of and response to selective cue-reward associations in order to better understand the neural basis of healthy and disordered reward seeking.

PI_NAMEs: BURKE, DENNIS ALEXANDER (contact)

PROJECT_TERMS: Adaptive Behaviors;Animals;Appetitive Behavior;approach behavior;Association Learning;Auditory;Automobile Driving;Behavior;behavioral response;Brain;Brain region;Calcium;Complex;Conditioned Reflex;conditioning;craving;Cues;Development;directed attention;Discrimination;discrimination task;Disease;Dopamine;Dopamine Antagonists;Dopamine D1 Receptor;Dopamine D2 Receptor;Environment;Evolution;Exhibits;experience;experimental study;Feedback;Food;Future;Goals;Head;Human;Image;Individual;Interruption;Learning;learning ability;Lesion;Methods;Motivation;Mus;neural;Neurons;Nucleus Accumbens;Opsin;optogenetics;Outcome;Partner in relationship;Pattern;Persons;Pharmaceutical Preparations;Pharmacology;Phase;Population;Process;Proteins;Relapse;Research;response;Rewards;Role;selective expression;serial imaging;Signal Transduction;Stimulus;Substance Use Disorder;Testing;Time;two photon microscopy;two-photon;Viral;Visual

PROJECT_TITLE: Nucleus accumbens dynamics underlying cue-reward learning


NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Digestive Diseases;Genetics;Human Genome

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Clonal expansions driven by somatic mutations arise almost ubiquitously throughout both healthy and diseased human tissues as we age. Some of these clones have been linked to chronic disease and other aging associated maladies, however, what drives clonal expansions and how they affect tissue integrity and function are not well defined. This project aims to develop and apply novel methods for the discovery of somatic mutations driving expansion in human tissue and multi -omic single-cell mapping of these driver mutation genotypes to molecular phenotypes.

PI_NAMEs: D'AVINO, ANDREW  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acceleration;Address;Adipose tissue;Affect;Age;age related chronic disease;Age related pathologies;age-related disease;aged;Aging;aging morbidity;aging population;aging process;aging related;aging related disease;Algorithms;Architecture;Automobile Driving;Awareness;Binding;biobank;Biological;Biological Assay;Biological Process;Biology of Aging;Blood Vessels;candidate identification;Cell Line;Cell Physiology;cell type;Cells;Chromatin;Chronic Disease;Clinical;Clonal Expansion;cohort;Coronary Arteriosclerosis;cost;Coupled;Data;data repository;Data Set;Development;Diabetes Mellitus;diabetic patient;Disease;DNA sequencing;Doctor of Philosophy;driver mutation;Elderly;Environment;Epigenetic Process;epigenome;epigenomics;fatty liver disease;Fellowship;FOXO1A gene;Frequencies;frontier;Gene Activation;Gene Expression;Genes;Genotype;Goals;healthy aging;Hematopoiesis;histone modification;Histones;Human;Human body;human data;human disease;Human Genetics;human tissue;Hypertension;Individual;Inflammation;innovation;insight;interest;Investigation;Islet Cell;Islets of Langerhans;laboratory experience;leukemia;life span;Link;Machine Learning;Maps;Marrow;Mentorship;Metabolic;Methods;Modality;model organism;Modeling;Molecular;molecular phenotype;mortality;Mosaicism;multimodality;multiple omics;mutant;Mutate;Mutation;Myeloproliferative disease;Nature;new technology;non-alcoholic fatty liver disease;novel;novel sequencing technology;obese patients;Obesity;Patients;Peripheral;Phenotype;Physicians;Play;pressure;programs;prototype;public database;recruit;Recurrence;Research Personnel;Resolution;Resources;Risk;RNA;Role;sample collection;Sampling;Scientist;Shapes;Somatic Mutation;Speed;Surveys;targeted treatment;Techniques;Tissue Sample;Tissues;tool;Training;transcription factor;transcriptome sequencing;Ulcerative Colitis;Variant;variant detection;Work

PROJECT_TITLE: Identification and characterization of clonal expansions in aging and aging-related disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Neutrophils are an important type of blood cells that play critical roles in immune responses and in human diseases, but their control mechanisms are incompletely understood. This project focuses on the functions of cell surface RNAs to elucidate a new dimension of neutrophil regulation.

PI_NAMEs: LU, JUN  (contact);WU, DIANQING

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Ablation;Acute;Address;Adherence;Affinity;Binding;Biological;Biology;Blood Cells;Blood Vessels;Catalogs;Cell Communication;Cell Nucleus;Cell Physiology;Cell surface;cell type;Chemicals;Circulation;Communities;Complex;Cytoplasm;Data;Defect;Dimensions;Endothelial Cells;Endothelium;experimental study;extracellular;Family;first responder;Future;Genes;glycosylation;Goals;Hematology;Hematopoietic;human disease;Immune response;In Vitro;in vivo;in vivo Model;infancy;Inflammation;Inflammatory;innate immune function;Integrins;intravital imaging;Lectin;Mammalian Cell;Maps;Mass Spectrum Analysis;Mediating;migration;Molecular;molecular domain;Nature;neutrophil;Neutrophil Infiltration;next generation sequencing;P-Selectin;P-selectin ligand protein;Pancreatic ribonuclease;Peritonitis;Phenotype;Play;Polysaccharides;Positioning Attribute;Process;Production;receptor;recruit;Regulation;Research Personnel;RNA;RNA Sequences;Role;Site;Small RNA;Structure;Testing;Time;Tissues;Transcript;Untranslated RNA;Visualization

PROJECT_TITLE: The role of cell surface RNAs in neutrophils

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-M (90)]


NIH_SPENDING_CATS: Bioengineering;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Pediatric;Social Determinants of Health;Transplantation

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE To address inequitable allocation, the kidney allocation system was changed in early 2021, and given the complex interplay of disparities in allocation, this change may have unintended consequences for vulnerable populations. Our goal is to develop robust equity metrics to study the impact of the new allocation system, both in ensuring equitable distribution of organs to transplant centers across the US based on patient priority on the waitlist, which was the aim of the policy change, and the new policy’s impact on kidney transplant rate for vulnerable populations who have historically been disenfranchised by allocation policy. Our results will guide the development of a more equitable allocation system.

PI_NAMEs: LIYANAGE, LUCKMINI  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: 6 year old;Address;Age;Algorithms;Blood;Characteristics;Childhood;Complex;Computer Simulation;Data;data integration;data registry;Data Science;Data Set;Data Sources;Databases;design;Development;disenfranchised population;Disparity;Disparity in diagnosis;Doctor of Philosophy;Education;Employment;Enrollment;Ensure;Epidemiologist;Epidemiology;Equity;Frustration;Funding;Future;Goals;Grant;health equity;Health Policy;Health Service Area;Hospitals;Incidence;indexing;Inequity;Instruction;Insurance;interest;Kidney;Kidney Failure;Kidney Transplantation;Learning;Link;long-standing disparities;Machine Learning;Measures;Mentors;Mentorship;Methodology;Methods;Modeling;novel;Operative Surgical Procedures;Organ;organ allocation;Organ Donor;Organ Transplantation;Output;Patient Care;Patients;Policies;population health;prevent;programs;Public Health;Race;Radial;Research;Research Methodology;Resources;Science;Scientist;sex;simulation;social deprivation;social health determinants;Statistical Methods;Surgeon;System;Time;Training;transplant centers;transplant model;Transplant Surgeon;Transplantation;Vulnerable Populations;Waiting Lists;Work

PROJECT_TITLE: Diagnosing disparities in existing and proposed allocation systems for kidney transplantation

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-G (O1)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Lung;Lung Cancer;Prevention;Rehabilitation;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: RICHMOND

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE While many cancer survivors will quit using tobacco after receiving a cancer diagnosis, many (13-60%) will go on to relapse due to reasons that are still not well understood. Intrapersonal factors (e.g., cancer worry, negative affect) and interpersonal factors (e.g., social support, social constraint) may play a role, but research has yet to examine their momentary or longitudinal influence on tobacco use relapse or risk of tobacco relapse among cancer survivors. This F31 NRSA award will provide the support to complete the proposed project, which aims to examine these predictors’ relation to tobacco use relapse using multiple methodologies (i.e., ecological momentary assessment, longitudinal survey), as well as provide the applicant with support to receive advanced training needed to pursue an independent research career in cancer prevention and tobacco control.

PI_NAMEs: FUGATE-LAUS, KENDALL  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Abstinence;Address;Adult;Advanced Malignant Neoplasm;Affect;Award;Baseline Surveys;Behavior;Cancer Center;Cancer Control;cancer diagnosis;cancer prevention;cancer recurrence;Cancer Survivor;Cancer Survivorship;career;Clinical;Collaborations;Complex;Data;Death Rate;design;Development;Diagnosis;Ecological momentary assessment;Eligibility Determination;Emotions;experience;Fellowship;follow-up;Fright;Future;Goals;Health;high risk;improved;inclusion criteria;Individual;innovation;Intervention;Knowledge;Longitudinal Surveys;Malignant Neoplasms;Mentors;Mentorship;Methodology;Methods;Mission;Modeling;Motivation;National Research Service Awards;negative affect;Newly Diagnosed;Outcome;Participant;patient population;Patients;peer support;Persons;Population;Positioning Attribute;prevent;Prevention;Quality of life;Recording of previous events;recruit;Relapse;relapse prevention;relapse risk;Reporting;Research;research data dissemination;Research Personnel;Risk;Second Primary Cancers;skills;social;social relationships;Social support;Statistical Methods;stem;Support System;Survey Methodology;Surveys;Survivors;Time;Tobacco;tobacco control;Tobacco use;Tobacco Use Cessation;Training;training opportunity;Translational Research;treatment program;Vulnerable Populations;Work

PROJECT_TITLE: Examining Tobacco Use Relapse among Cancer Survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Learning when rewards are not available allows for adaptive decision making, as time and energy can be redirected towards available rewards. Such learning and subsequent decision making are impaired in disease states, including substance use disorder, though the precise mechanism of this is unknown. This project will evaluate the neural systems involved in the formation of inhibitory associations and how these associations guide choice behavior.

PI_NAMEs: NETT, KELLE  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TITLE: Examining basolateral amygdala function in the development of inhibitory associations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, successfully evades host defenses to make it one of most infectious pathogens in the world. The goal of this project is to determine how a key innate immune regulator (TRIM14) regulates host immune responses and mitochondria homeostasis in Mtb-infected macrophages. Determining the role TRIM14 has in regulation of a macrophage’s activity during Mtb infection may lead to the identification of novel therapeutic targets to control infection in human patients.

PI_NAMEs: MABRY, CORY  (contact)

PROJECT_TERMS: Alleles;Anti-Bacterial Agents;antiviral immunity;Apoptosis;Apoptotic;Biochemistry;Biological Response Modifiers;Black Box;Cell Death;Cell Nucleus;Cell Physiology;Cell Proliferation;Cells;Data;Defect;design;disease model;DNA;experimental study;Family member;Female;Future;Gene Expression;Generations;Goals;Health;Homeostasis;Host Defense;Human;human pathogen;IFNAR1 gene;Immune;Immune response;Immune signaling;Immunity;improved;In Vitro;in vivo;Infection;Infection Control;Inflammation;Innate Immune Response;insight;interest;Interferons;Interphase Cell;Knowledge;Laboratory Finding;Lung;Macrophage;Measures;Mediating;member;Membrane Potentials;Metabolic;metabolic profile;Metabolism;Mitochondria;Mitochondrial Matrix;mitochondrial membrane;mitochondrial metabolism;mouse model;Mus;Mycobacterium tuberculosis;Natural Immunity;new therapeutic target;novel;novel therapeutic intervention;Outcome;Output;Oxidative Phosphorylation;pathogen;pathogenic bacteria;Pathway interactions;Patient-Focused Outcomes;Patients;Phosphorylation;Phosphotransferases;Play;Population;Proliferating;Protein Family;Proteins;Reactive Oxygen Species;Regulation;Respiration;response;Role;Signal Pathway;STAT3 gene;TBK1 gene;Testing;Training;transcription factor;Transcriptional Activation;TRIM Motif;Tuberculosis;tumorigenesis;ubiquitin-protein ligase;Work

PROJECT_TITLE: TRIM 14 is a master regulator of STAT3 activity during the macrophage innate immune responses to Mycobacterium tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because obesity is a major health problem in the United States and is a leading contributor to cardiovascular disease, diabetes mellitus and stroke. The expected contribution of these studies will be a better understanding of the circuitry of the Nucleus of the Solitary Tract (NTS) in the brainstem, which is essential for the control of food intake, and in particular the NPY-expressing neurons in this region. The expectation is that increasing our understanding of circuits critical for the control of food intake will help direct more targeted strategies for the prevention and alleviation of the detrimental effects of obesity.

PI_NAMEs: APPLEYARD, SUZANNE M (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Agonist;Appetite Stimulants;Area;Behavior;Brain region;Brain Stem;Calories;Cardiovascular Diseases;Catecholamines;Consumption;Data;Diabetes Mellitus;Diet;Eating;Electrophysiology (science);Equilibrium;expectation;Fasting;Fatty acid glycerol esters;Fiber;Food;gamma-Aminobutyric Acid;Goals;Health;High Fat Diet;Image;improved;Injections;innovation;interdisciplinary approach;Knowledge;Length;Mediating;Metabolic;Modality;Molecular;Neurons;neuropeptide Y2 receptor;neurotransmitter release;Norepinephrine;novel;Nucleus solitarius;Obesity;obesity development;obesity treatment;optogenetics;Pathway interactions;Peptides;Pharmacology;Physiological;Population;prevent;Prevention strategy;Process;Public Health;receptor;Research;Satiation;sex;Stroke;Structure of nucleus infundibularis hypothalami;sugar;Testing;Therapeutic;United States;Weight Gain

PROJECT_TITLE: How NTS NPY neurons alter NTS circuitry to promote food intake

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-S (02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Pediatric

PHR: PROJECT NARRATIVE Axon pruning is a process that refines the connections between brain regions throughout development, and increasing evidence supports a failure of this process in several neurodevelopmental disorders. By inhibiting long-range developmental axonal pruning, this project will address a significant gap in understanding how aberrant connectivity emerges and contributes to the altered cortical organization and function seen in these disorders.

PI_NAMEs: DAVIDSON, RINA LEAH (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Ablation;Adolescent;Affect;Anatomy;autism spectrum disorder;Axon;axon growth;Birth;Brain region;CASP9 gene;cell type;Cellular Morphology;Communities;Contralateral;Defect;Development;Disease;Enzymes;excitatory neuron;experimental study;Failure;FOS gene;Functional disorder;Genomics;Goals;Growth;Histologic;histological stains;inhibitory neuron;Injections;insight;Institution;Interneurons;Ipsilateral;Label;Link;Medial;Medial Dorsal Nucleus;Mentorship;Methods;migration;Modeling;Molecular;Molecular Analysis;Monitor;mouse model;Mus;neural;neural circuit;Neurodevelopmental Disorder;Neurologic Dysfunctions;Neurons;Neurophysiology - biologic function;neuropsychiatric disorder;novel;novel strategies;Play;postnatal;postnatal development;Prefrontal Cortex;Process;Research;Role;sensory cortex;Specificity;stem cells;Synapses;Testing;Thalamic Nuclei;Thalamic structure;Time;tool;Tracer;Ventral Anterior Thalamic Nucleus;Virus;Visualization

PROJECT_TITLE: The Impact of Thalamocortical Axon Refinement on the Development of the Prefrontal Cortex

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Eye Disease and Disorders of Vision;Intellectual and Developmental Disabilities (IDD);Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative CDKL5 deficiency disorder (CDD) is a rare neurodevelopmental condition associated with cortical visual impairment, neuronal hyperexcitability, and dysregulation of arousal states. Using a mouse model of CDD, I will determine the impact of CDKL5 deficiency on state-dependent thalamocortical network dynamics and identify circuit-level mechanisms underlying how loss of CDL5 contributes to altered visual sensitivity. We expect our results to provide insight into the functional consequences of CDKL5 deletion in mice, with a focus on behavioral state modulation of thalamocortical dynamics and the balance between feedforward and intracortical functional connectivity.

PI_NAMEs: OREN, RACHEL  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Action Potentials;Address;Affect;Animals;area striata;Arousal;autism spectrum disorder;autism symptoms;awake;Axon;Behavior Disorders;Behavior monitoring;Behavioral;Calcium;calcium indicator;CDKL5 disorder;cell cortex;cerebral visual impairment;Color;Contrast Sensitivity;Coupled;Cyclin-Dependent Kinases;Data;Development;Disease;Dorsal;Equilibrium;Exhibits;experimental study;extrastriate visual cortex;Genes;Genetic Diseases;Goals;Grooming;Head;High Prevalence;Hippocampus;Human;Image;imaging modality;in vivo;insight;Link;Locomotion;Measures;Monitor;mouse model;Mus;mutant;Mutation;Mydriasis;Neocortex;Nervous System Physiology;neural;Neurons;Patients;Pattern;Physiological Processes;Population;Pupil;Regulation;Research;response;Running;Seizures;Sensory;sex;spatiotemporal;Specificity;Synapses;Techniques;Testing;Thalamic structure;Viral;Vision Disorders;Visual;Visual Cortex;Visual evoked cortical potential;Visual impairment;visual information;visual processing;Work

PROJECT_TITLE: Impact of CDKL5 deficiency on thalamocortical dynamics


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurosciences

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Magnetic Resonance Elastography (MRE) is an in vivo technique for assessing mechanical properties of tissues such as the brain and has many potential clinical applications for the diagnosis and characterization of various aging-related dementias as it is sensitive to microstructural changes that may occur before any macroscopic structural changes occur. However, it is often difficult to implement the MRE technique in clinical and research settings to assess aging and aging-related conditions because of long acquisition times and the need for specialized equipment to cause external vibrations to pass through the brain. This project aims to improve the utility of MRE technology through the implementation of a new MRE acquisition and processing method which uses intrinsic motion of the brain from the cardiac cycle and a novel sampling technique to accelerate data acquisition and improve data quality without the need for specialized equipment.

PI_NAMEs: KRAMER, MARY  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Acceleration;Address;Adult;Advanced Development;Affect;age related;age related neurodegeneration;Aging;aging related;aging related disease;Algorithms;Alzheimer's Disease;American;Atrophic;Birth Rate;Brain;brain health;Brain Mapping;Brain region;brain tissue;burden of illness;Cardiac;care costs;Censuses;Cerebrovascular Circulation;Child;Clinical;clinical application;cognitive performance;cohort;Creativeness;Data;data acquisition;Data Analyses;data quality;Dementia;demographics;Development;Diagnosis;Disease;Early Diagnosis;Early Intervention;Economics;elastography;Equipment;Estimation Techniques;Evaluation;experience;Financial Hardship;flexibility;Frequencies;Healthcare Systems;Image;Imaging Techniques;Impaired cognition;improved;in vivo;in vivo evaluation;in vivo imaging;Individual;Infrastructure;insight;interest;Intervention;Longevity;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Measures;mechanical properties;Mechanics;Methods;Motion;neuroimaging;Neurologic;Noise;normal aging;novel;older adult;Participant;Pathologic;pathological aging;Patients;Phase;Population;Positioning Attribute;Public Health;reconstruction;Recording of previous events;Research;research study;Resolution;Resources;response;Sampling;Scanning;Scheme;Signal Transduction;Source;spatiotemporal;Special Equipment;Speed;success;System;Techniques;Technology;Therapeutic Intervention;Time;tissue mapping;Tissues;United States;Validation;vibration;Work;young adult

PROJECT_TITLE: In Vivo Evaluation of Brain Tissue Integrity in Aging Using a Novel Magnetic Resonance Elastography Technique

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Narrative Influenza viruses infect a broad range of species including humans, pigs, domestic birds (chickens, ducks) and water fowls; these viruses infect host cells by binding to cell surface glycans, which vary among host species. Zoonotic influenza viruses capable of efficiently utilizing human glycans can cause pandemics in humans. The goal of this proposal is to identify the types of glycans necessary for influenza virus infection of different hosts and develop a technology platform that can reliably assess and identify zoonotic influenza virus strains cable of causing human infections.

PI_NAMEs: MANICASSAMY, BALAJI  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: A549;Anabolism;Animals;Avian Influenza A Virus;Bar Codes;Binding;Binding Sites;Biological Assay;Birds;Carbohydrates;Carbon;Cell Differentiation process;Cell Line;Cell surface;cell type;Cells;Ceramides;Chemicals;Chickens;Chiroptera;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR library;CRISPR/Cas technology;cross-species transmission;Defect;Development;domestic bird;Ducks;Electroporation;Electrospray Ionization;Enzymes;Epidemic;Epithelial Cells;Family;Family suidae;fitness;flexibility;flu transmission;Fucose;Galactose;Genes;Glucose;Glycoconjugates;Glycolipids;Glycosphingolipids;glycosyltransferase;Goals;Health;Human;Hybrids;Individual;Infection;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;Influenza A Virus, H5N1 Subtype;Influenza A Virus, H7N7 Subtype;Influenza A Virus, H7N9 Subtype;Influenza A Virus, H9N2 Subtype;influenza infection;influenza virus strain;influenzavirus;insight;Investigation;Knock-out;Lectin;Libraries;Link;Lung;Mannose;Maps;member;multiple omics;mutant;N-acetyllactosamine;N-Acetylneuraminic Acid;nanoelectrospray;Oligonucleotides;pandemic disease;pandemic potential;Physiological;polylactosamine;Polysaccharides;post-pandemic;Predisposition;receptor;Role;Seasons;Shapes;Shotguns;Sialic Acids;Site;Structure;sugar;tandem mass spectrometry;Techniques;Technology;technology platform;Trachea;transmission process;Upper Respiratory Infections;Viral;Virus;Virus Diseases;Virus Receptors;Virus Replication;Water;Western Blotting;Zoonoses

PROJECT_TITLE: Investigation of host glycan requirements for the transmission of influenza viruses at the human-animal interface

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 VDT-Q (01)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Candida auris is an emerging identified fungal pathogen that is very concerning because of its resistance to multiple antifungal drugs, rendering some strains untreatable. We propose here to use genetic tools to study virulence and antifungal drug resistance, to gain new insight into how this organism causes disease. In doing so, we will create a community resource that can be used for myriad purposes.

PI_NAMEs: GARSIN, DANIELLE A;LORENZ, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Agrobacterium;Amphotericin B;Animal Model;Animals;anti-fungal agents;Attenuated;Azole resistance;Bacteria;Biological Assay;Biology;Caenorhabditis elegans;Candida;Candida albicans;Candida auris;Candida glabrata;Cells;Clinic;Clinical;Codon Nucleotides;Communities;Data;Disease;Distant;DNA Insertion Elements;Drug resistance;Elements;emerging pathogen;Environment;Fluconazole;Fluconazole resistance;Frequencies;Fungal Drug Resistance;Future;gene conservation;Genes;Genetic;genetic analysis;genetic approach;genetic resource;Genetic Screening;Genome;Geography;Goals;Growth;Haploidy;Health care facility;Healthcare;high throughput screening;Hospitals;improved;improved outcome;Incidence;Infection;infection management;Insertional Mutagenesis;insight;interest;large datasets;Libraries;Long-Term Care;Mediating;Methodology;Methods;Modeling;Morphology;Multiple Fungal Drug Resistance;Mus;Mutagenesis;mutant;Mycoses;Nematoda;Organism;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phenotype;Polyenes;Predisposition;public repository;Research;Resistance;resistance in Candida auris;resistance mechanism;Resources;Rhizobium radiobacter;Screening procedure;Severities;Site;Skin colonization;Surface;System;tool;trait;Type IV Secretion System Pathway;vector;Virulence;World Health Organization

PROJECT_TITLE: Genetic approaches to probe virulence and drug resistance in Candida auris

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Lung;Social Determinants of Health

PHR: PROJECT NARRATIVE  The inhalation of air pollutants such as polyaromatic hydrocarbons (PAHs), volatile organic compounds (VOCs), black carbon (BC), and particulate matter (PM)—all compounds that can be found in restaurant kitchens—often results in adverse health effects. To investigate an occupational environment with limited toxicological exposure data in the United States, this proposed research study will chemically characterize air pollution in numerous western-style industrial kitchens and analyze factors contributing to their trends. In order to determine the extent to which this exposure results in adverse health outcomes, a risk assessment and biomarker analysis will be performed to compare the cardiopulmonary health of culinary workers to that of non- exposed workers.

PI_NAMEs: SAPORITO, ANTONIO  (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Address;Adverse event;Advocate;Aerosols;Age;Air Pollutants;Air Pollution;Ames Assay;Area;Aromatic Polycyclic Hydrocarbons;Biological Markers;Biological Monitoring;biomass fuel;Blood Pressure;cancer classification;Carbohydrates;Carbon Black;Carcinogens;Cardiopulmonary;career;Chemicals;Chronic;Chronic Bronchitis;cohort;Complex;Confounding Factors (Epidemiology);cooking;Data;demographics;Disparity;Employment;Environment;Environmental Exposure;Environmental Health;epidemiologic data;Evaluation;Exposure to;Face;Fatty acid glycerol esters;fine particles;Food;Food Services;Future;Gas Chromatography;Gases;Health;health disparity;Health Hazards;Health Status;Heart Diseases;High temperature of physical object;Hour;Household;improved;Industrialization;Industry;Inhalation;International Agency for Research on Cancer;Investigation;laboratory experiment;Lipid Peroxidation;Lipids;Liquid Chromatography;Literature;Malignant neoplasm of lung;Mass Spectrum Analysis;Measurement;Measures;mortality;Natural Gas;New York City;non-smoking;Occupational;Occupational Exposure;Occupational Health;Occupational Status;Oils;Optics;Outcome;particle;Particulate;Particulate Matter;Persons;Population;Preparation;Probability;Process;Proteins;Publishing;pulmonary function;recruit;Research Personnel;research study;Restaurants;Risk;Risk Assessment;Sampling;Spirometry;Techniques;Temperature;Testing;Time;Toxicology;Training;trend;ultrafine particle;underserved community;United States;urinary;Urine;vaporization;ventilation;volatile organic compound;Wood material;Work;working class;Xenobiotics

PROJECT_TITLE: Investigation of Cooking Aerosol Emissions and Health Effects due to Exposure in an Occupational Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Allergic Rhinitis (Hay Fever);Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Pollen-related illnesses affect 60 million Americans and emerging evidence suggests pollen may contribute to respiratory health disparities. This research aims to understand individual and area-level factors driving pollen- related health disparities across the US, investigate the synergistic effects of pollen and air pollution, and discover potential differences in pollen exposures across Atlanta communities through the use of automated pollen sensors. Results from this work will guide clinical recommendations and targeted interventions aimed at reducing health disparities and improving health outcomes for millions of people.

PI_NAMEs: LAPPE, BROOKE  (contact)

PROJECT_TERMS: Affect;Air Pollution;Allergens;Allergic rhinitis;ambient air pollution;American;Area;Asthma;Automobile Driving;Biostatistical Methods;black patient;Cells;Characteristics;Cities;climate change;climate-related health;Clinical;Communication;Communities;Data;Databases;Diesel Exhaust;Disease;Disparity;Economic Burden;Educational process of instructing;Emergency department visit;environmental justice;Environmental Risk Factor;Epidemiology;Epithelium;ethnic minority;ethnic minority population;Exposure disparity;Exposure to;Fellowship;Geography;Goals;Grain;Health;Health Care Costs;health disparity;health equity promotion;Hypersensitivity;Immune system;improved;Individual;Industry;Inflammatory;insight;interest;Intervention;Investigation;Joints;Link;Location;Low income;Low Income Population;low socioeconomic status;Medical Care Costs;medically underserved population;Mentorship;Methods;Minority;minority communities;Minority Groups;minority patient;Monitor;Morbidity - disease rate;Outcome;Ozone;particle;Patients;Pattern;Penetration;Permeability;Persons;Poaceae;Policies;Pollen;Population;pre-doctoral;Predisposition;Prevalence;Production;Public Health;racial minority;racial minority population;Recommendation;Reduce health disparities;Research;respiratory;respiratory health;respiratory morbidity;Rhinitis;Risk;Science;Seasons;sensor;Series;Site;Social Processes;social vulnerability;socioeconomic disparity;socioeconomics;spatiotemporal;Testing;Time;Training;Trees;trend;United States National Institutes of Health;urban area;Wheezing;Work

PROJECT_TITLE: Improved estimation of pollen exposure, mixtures, and risk of respiratory illness


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

PHR: PROJECT NARRATIVE Dysregulation of mitochondrial homeostasis is a major contributor to human disease. This project aims to explore the role of mitochondrial dynamics in the innate immune system by investigating the interplay between mitochondrial fission, oxidative stress, and cardiolipin externalization in regulating inflammation and cell death in macrophages. The findings will enhance our understanding of the regulatory role of mitochondrial dynamics in the innate immune system and potentially inform the development of novel therapeutic interventions targeting mitochondrial function and homeostasis.

PI_NAMEs: MARTINEZ, EDUARDO  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Affect;Alleles;Binding;Biochemical;Cardiolipins;Cataloging;Catalogs;Cell Death;cell type;Cells;Central Nervous System;Chronic;chronic inflammatory disease;Communicable Diseases;Crohn's disease;Cytosol;Data;Development;Disease;Disease Outcome;DNA Sequence Alteration;Drug Design;Electron Transport;experience;experimental study;Functional disorder;gain of function;gain of function mutation;Genes;genome wide association study;Goals;Heart Diseases;Homeostasis;Hormonal;human disease;Immune;Immunity;immunopathology;improved;Infection;Inflammasome;Inflammation;Inflammatory;inhibitor;innate immune function;Innate Immune Response;Innate Immune System;Inner mitochondrial membrane;insight;interest;Knowledge;leucine-rich repeat protein;Link;Lipids;LRRK2 gene;Macrophage;Malignant Breast Neoplasm;Measures;Mediating;Membrane;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Modeling;Molecular;Mus;Mutation;mycobacterial;Mycobacterium Infections;Natural Immunity;Nervous System Disorder;Nervous System Physiology;novel;novel therapeutic intervention;Outcome;Outer Mitochondrial Membrane;Oxidative Stress;Parkinson Disease;Patient-Focused Outcomes;Peripheral;Phospholipids;Predisposition;Process;Production;Proteins;Reactive Oxygen Species;recruit;response;RIPK1 gene;RIPK3 gene;Role;Series;Signal Transduction;Stress;stressor;targeted treatment;Testing;Therapeutic Intervention;therapy design;Tuberculosis;Work

PROJECT_TITLE: Uncovering the role of cardiolipin in promoting gasdermin D-mediated necroptosis and hyperinflammation


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE This project aims to enhance our understanding of the factors that influence the variable penetrance and expressivity of monogenic variants. Here, we define “penetrance” as the percentage of carriers that show disease and “expressivity” as the severity of the phenotype within carriers. Identifying factors that affect penetrance and expressivity has a direct impact on public health by identifying monogenic carriers who will need more aggressive treatment to manage their symptoms.

PI_NAMEs: WEI, ANGELA N (contact)

PROGRAM_OFFICER_NAME: HINDORFF, LUCIA

PROJECT_TERMS: Address;advanced disease;Affect;aggressive therapy;Alleles;American;autosome;Benign;biobank;Blood Glucose;Body mass index;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Categories;Classification;Clinical;clinical phenotype;Collaborations;Colorado;Data;Diet;Disease;disease phenotype;Disease susceptibility;disease-causing mutation;Environmental Risk Factor;European ancestry;exome;exome sequencing;gain of function;gene interaction;Genes;Genetic;Genetic Diseases;Genetic Epistasis;genetic predictors;Genetic Research;genetic variant;Genetic Variation;genomic data;Health system;Healthcare;Healthcare Systems;Heterozygote;improved;Individual;Knowledge;Language;Life Style;Link;loss of function;Low-Density Lipoproteins;Mendelian disorder;Mutation;non-genetic;Onset of illness;Pathogenicity;patient population;Patients;Penetrance;personalized medicine;Phenotype;phenotypic data;polygenic risk score;Population;Population Heterogeneity;Proteins;Public Health;rare variant;recessive genetic trait;Risk Factors;Running;Severities;Severity of illness;Source;Symptoms;trait;Treatment Cost;Triglycerides;Universities;Variant;variant of unknown significance;Visit;Work

PROJECT_TITLE: Identifying sources of variable penetrance and expressivity in monogenic diseases at population scale


NIH_SPENDING_CATS: Aging;Genetics;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Insulin resistance, a common and serious health problem, can be associated both with obesity and old age. Recent discoveries point to dysfunction in fat tissue as a culprit; proposed studies will build on those findings and explore the altered biochemistry of fats that leads to that dysfunction. Insights from these studies will inform therapies for age- and obesity-acquired insulin resistance, for which treatment options are currently limited.

PI_NAMEs: MONROE, BLAKE  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: 4 hydroxynonenal;Acyltransferase;adduct;Adipocytes;adipose derived stem cell;Adipose tissue;Age;age related;Age related pathologies;age-related disease;Aging;Aldehydes;Alkylation;antioxidant enzyme;BAX gene;Biochemistry;Blood Vessels;Cardiolipins;CDKN1A gene;Cell Aging;Cell Culture Techniques;Cells;cytokine;Data;Data Analyses;Development;diet-induced obesity;Diffuse;DNA;Down-Regulation;Enzymes;Exhibits;experimental study;Exposure to;Faculty;Fatty acid glycerol esters;Fellowship;Fibroblasts;Functional disorder;Generations;Genes;Genetic;genotoxicity;glutathione peroxidase;Glutathione S-Transferase;Health;Human;human old age (65+);Immune;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory milieu;insight;Insulin Resistance;Intervention;Laboratories;life span;Link;lipid metabolism;Lipid Peroxidation;Lipid Peroxides;Lipids;lipophilicity;loss of function;Lung;Mediating;Mediator;Mentors;Metabolic dysfunction;Minnesota;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Mitochondrial Proteins;Modeling;Modification;Molecular;mortality;mouse model;Mus;Nature;novel;Obesity;obesity development;Oxidative Stress;Pathogenesis;Pathology;Permeability;peroxidation;pharmacologic;Phenotype;Phospholipids;Physiological;Post-Translational Protein Processing;programs;Proteins;Proteomics;Public Health;Research;Research Personnel;Role;senescence;senescence associated secretory phenotype;senescent cell;Sentinel;Signal Pathway;Signal Transduction;Sirtuins;Site;skills;stem cells;Stress;Sum;Testing;Tissue-Specific Gene Expression;Tissues;Universities;Up-Regulation;Visceral;Work

PROJECT_TITLE: Lipid Metabolism, Mitochondrial Stress, and Senescence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


NIH_SPENDING_CATS: Biotechnology;Cachexia;Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE Pancreatic cancer-mediated muscle cachexia is a severe wasting syndrome that occurs in virtually every patient and strongly predicts poor outcome. How pancreatic cancer drives muscle cachexia is still unfolding. Upon completion, this study will shed new insights into mechanistic paradigms of muscle cachexia and hopefully thereby pave the way for therapeutic breakthroughs to curb this life-threatening condition.

PI_NAMEs: ATFI, AZEDDINE  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Ablation;Acceleration;Antibodies;Binding;Bispecific Antibodies;Bispecific Monoclonal Antibodies;Body Weight decreased;Cachexia;Cancer Cachexia;cancer cell;Cancer Patient;CDKN2A gene;Cells;Cessation of life;combat;Complication;design;Disease;Dose;Drug toxicity;Embryo;Epithelium;Event;experimental study;Fibroblasts;Functional disorder;Gene Expression;Genes;Genetic;Heterozygote;human model;improved;Incidence;Individual;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;KRASG12D;Lead;Life;Malignant neoplasm of pancreas;Mediating;Membrane;Modeling;mouse model;Mus;Muscle;muscle form;Muscle function;muscle strength;Muscular Atrophy;mutant;neoplastic cell;novel therapeutics;Nuclear;Organ;Outcome;overexpression;Pancreas;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Patient-Focused Outcomes;Patients;pharmacologic;Phenotype;Quality of life;receptor;Recombinants;reduced muscle mass;Reporting;Resistance development;Role;Signal Transduction;Skeletal Muscle;Syndrome;Testing;Therapeutic;therapeutic evaluation;transcriptome sequencing;Transforming Growth Factor alpha;Transgenes;translational potential;Treatment Efficacy;Tumor Necrosis Factor Receptor;virtual;Wasting Syndrome

PROJECT_TITLE: Targeting cancer cachexia drivers using antibody-based approaches

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Obesity has become a major public health concern as it increases the risk for type 2 diabetes, heart attack, certain forms of cancer, hypertension and stroke. This research proposal aims to develop technologies for modulation of gene expression specifically in neurons involved in the control of body weight in mice and to use these approaches to determine how gene mutations affect food intake and body weight in certain patients. This research could lead to a better understanding on how people become obese and could lead to new treatments for this condition.

PI_NAMEs: BLAKE, ABBEY  (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Ablation;adenylyl cyclase III;Adult;Affect;Alleles;Alstrom syndrome;Anatomy;Bardet-Biedl Syndrome;Body Weight;cancer type;Cause of Death;Cell model;Cell Surface Extensions;cell type;Cells;Cilia;ciliopathy;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR interference;Data;Defect;Dependovirus;Development;Down-Regulation;Eating;Family Study;Gene Expression;Gene Mutation;gene repression;Genes;genetic manipulation;Genetic Predisposition to Disease;Genetic Transcription;Genetic Variation;Guide RNA;Heritability;Homeostasis;Human;human disease;Hypertension;Hypothalamic structure;improved;in vivo;inducible Cre;Laboratories;Leptin;Malignant Neoplasms;Mediating;Melanocortin 4 Receptor;Modeling;Morbid Obesity;Mus;Mutation;Myocardial Infarction;Neurons;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Organelles;Output;paraventricular nucleus;Patients;Persons;Physiological;Population;Pro-Opiomelanocortin;Proteins;Public Health;Quality Control;Regulation;Research;Research Proposals;Risk;Role;Signal Transduction;Specificity;Stroke;Structure of nucleus infundibularis hypothalami;System;Technology;Testing;Therapeutic;tool;Twin Studies;Validation;Variant;Work

PROJECT_TITLE: Evaluating the Role of Human Obesity Genes in Specific Neuronal Populations in vivo by CRISPRi

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-2 (O1)]


NIH_SPENDING_CATS: Infectious Diseases;Natural Products

PHR: PROJECT NARRATIVE Acanthamoeba castellanii is a pathogenic free-living amoeba responsible for central nervous system human infections that are almost always fatal. The proposed research will aim to identify potent amoebicidal compounds produced by Pseudomonas aeruginosa, an environmental bacteria that co-exists with A. castellanii, and determine how these are inducing cell death. This work will therefore identify novel natural products that will bring us closer to treating devastating human infections caused by A. castellanii and other free-living amoebae.

PI_NAMEs: COLÓN RÍOS, REBECCA ISABEL (contact)

PROJECT_TERMS: Acanthamoeba castellanii;Amoeba genus;antimicrobial;Bacteria;Bacterial Infections;Biological Assay;candidate identification;Cause of Death;Cell Death;Cell Death Induction;Cell Fraction;Cell membrane;Cell Membrane Permeability;Cell Physiology;Cells;Central Nervous System;Central Nervous System Infections;Cessation of life;Chemical Weapons;Chemistry;Collaborations;Communication;Cytoplasm;Data;Death Rate;DNA Damage;drug discovery;drug repurposing;effective therapy;efficacy testing;Environment;experience;Family;Female;Fractionation;Goals;graduate student;Gram-Negative Bacteria;granulomatous amebic encephalitis;Hour;Human;Human Cell Line;Immunocompromised Host;Infection;interest;Keratitis;Knowledge;Laboratories;Latina;Lethal Dose 50;Lipids;Mammalian Cell;Mass Spectrum Analysis;Mentors;Metabolic;Microbial Biofilms;Microbiology;microorganism;Mitochondria;Molecular Biology;Morphology;Motility;mutant;Mycoses;Natural Compound;Natural Product Drug;Natural Products;Necrosis;NMR Spectroscopy;novel;novel therapeutics;Nuclear Magnetic Resonance;Parasitic infection;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenazines;Postdoctoral Fellow;pressure;Pseudomonas aeruginosa;Quinolones;Research;rhamnolipid;Scientist;skills;small molecule;Soil;Structure;Testing;Therapeutic Agents;Toxic effect;Training;Treatment Protocols;Vision;Water;Work

PROJECT_TITLE: Determining the mechanism of cell death of small molecules produced by Pseudomonas aeruginosa against Acanthamoeba castellanii


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Complementary and Integrative Health;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Nutrition;Social Determinants of Health

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Air pollution is a serious and growing health concern that effects millions of people globally. Ozone (O3) is a highly reactive gas defined as one of six criteria air pollutants by the environmental protection agency that increases morbidity and mortality of pulmonary diseases. This proposal will identify the mechanisms of resolution from O3-induced inflammation driven by docosahexaenoic acid and its metabolites to reveal potential targets for therapeutic intervention.

PI_NAMEs: YAEGER, MICHAEL JEROME (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Academia;Acceleration;Adverse effects;Air Pollutants;Air Pollution;alpha-Linolenic Acid;Alveolar Macrophages;Apoptotic;Binding;Biological;career;career development;CD59 Antigen;Cell membrane;Cells;Cessation of life;chemokine;Chronic lung disease;Consumption;criteria air pollutant;cytokine;Data;Diet;Disease;Docosahexaenoic acid supplementation;Docosahexaenoic Acids;Dose;Economics;Ensure;Environmental Air Pollutants;Enzymes;Essential Fatty Acids;exposed human population;Exposure to;Fatty Acids;Frequencies;Future;Gases;global temperature;GPR6 gene;Health;Immune;Immunologics;improved;In Vitro;Industrialization;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injury;Laboratories;Leucine-Rich Repeat;Linolenic Acids;Lung;Lung Diseases;lung health;lung injury;Macrophage;Measures;Mediating;Mediator;Mentors;Metabolism;Molecular;Molecular Target;monocyte;Morbidity - disease rate;mortality;Mus;Myeloid Cells;Omega-3 Fatty Acids;Oxidative Stress Induction;Ozone;ozone exposure;Pathway interactions;Patients;Pattern;Persons;Phagocytosis;Pharmacologic Substance;Phenotype;Phospholipids;pollutant;Polyunsaturated Fatty Acids;premature;prevent;Process;Production;Proteins;Publishing;Pulmonary Inflammation;Reaction;Recovery;recruit;Reducing diet;Reporting;Research Personnel;Resolution;response;Role;Severities;Signal Induction;Signal Transduction;Structure of parenchyma of lung;success;Sunlight;targeted treatment;Techniques;Testing;Therapeutic Intervention;Training;United States Environmental Protection Agency;uptake;Vehicle Emissions;Very Long Chain Fatty Acid

PROJECT_TITLE: The role of endogenous docosahexaenoic acid in resolving ozone induced lung inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative Despite their success in eradicating many pathogens, there are still many diseases for which vaccines do not currently exist. One exciting way to improve vaccines is delivering antigens with multiple adjuvants directly to dermal layers, activating distinct pathways specifically against that antigen. This research proposal will probe how combinatorial vaccines induce effective immune responses by using microneedle arrays—small, polymer patches of needles hundreds of microns long— to painlessly deliver antigen with precise ratios of adjuvants directly to dermal layers.

PI_NAMEs: EDWARDS, CAMILLA MARIE (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immunity;Adjuvant;Agonist;Amino Acid Sequence;Antigen Presentation;Antigen-Presenting Cells;Antigens;Autoimmunity;Automobile Driving;Award;Beds;Binding;Biocompatible Materials;Blood Vessels;Cancer Model;capsule;cell motility;Cell Proliferation;Cells;Charge;Chemicals;Clinical;Coculture Techniques;combat;combinatorial;controlled release;COVID-19;cytokine;Dangerousness;Data;Dendritic Cells;density;Dermal;design;Disease;disease model;Disease Outcome;Effector Cell;effector T cell;emerging pathogen;Emerging Technologies;Ensure;Funding;Gene Expression;Goals;Immune;Immune response;Immune signaling;Immune system;Immunologics;immunotoxicity;improved;In Vitro;in vivo;Infiltration;Inflammatory;Inflammatory Response;Injectable;Knowledge;Langerhans cell;Libraries;Link;lymph nodes;Lymphocyte;Measures;Mediating;Melanoma;migration;Modeling;Molecular;Mus;Needles;Neoplasm Metastasis;novel vaccines;Organ;Outcome;pain receptor;Painless;particle;pathogen;Pathway interactions;Pattern;Penetration;Polymers;Population;prevent;protein aminoacid sequence;receptor;Receptor Signaling;recruit;Research;Research Proposals;response;self assembly;Sentinel;Signal Transduction;Site;Skin;Smallpox;Specificity;Spleen;success;Surface;T cell response;T-Cell Activation;T-Lymphocyte;Technology;Testing;tissue resident memory T cell;TLR3 gene;TLR9 gene;Toll-like receptors;trafficking;Training;Tumor Burden;tumor growth;United States National Institutes of Health;vaccination outcome;vaccine acceptance;Vaccine Research;vaccine response;Vaccines

PROJECT_TITLE: Combinatorial control of TLR signaling using self-assembly of immune signals on microneedle arrays to access the skin niche


NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases;Lung;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

PHR: Narrative The gut microbiome is significantly altered in premature infants, who are at higher risk for adverse outcomes to respiratory infections such as respiratory syncytial virus (RSV). Our studies will investigate whether altered state of the premature microbiome affects the ability of the immune system to effectively deal with infection, and to define the contributions of the altered gut microbiome to the outcome of RSV infection in preterm infants. Identifying bacteria and metabolites that might be used to “normalize” the respiratory immune response to RSV infection will have the potential to improve the outcome of RSV infection in vulnerable premature infants.

PI_NAMEs: BROWN, JULIA  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: adaptive immune response;adverse outcome;Affect;airway immune response;Antibiotics;Antibody Response;Antibody Therapy;Antigen Presentation;Asthma;Award;B-Lymphocytes;Bacteria;Bacteroides;Bacteroides thetaiotaomicron;Birth;Bronchiolitis;Bronchoconstriction;Cells;Chronic Obstructive Pulmonary Disease;Clinical Trials;Coculture Techniques;Collaborations;commensal microbes;Complex;Data;defined contribution;Dendritic cell activation;Dendritic Cells;Development;Disease;dysbiosis;Eligibility Determination;Enterobacteriaceae;Equilibrium;experience;Feces;Foundations;Gastrointestinal Diseases;Generations;Germ-Free;gut bacteria;gut microbiome;Health;high risk;high risk infant;Immune;Immune response;Immune system;Immunity;Immunocompromised Host;Immunomodulators;immunoregulation;Impairment;improved;improved outcome;In Vitro;in vivo;Infant;Infection;Inflammation;Inflammatory Bowel Diseases;Innate Immune Response;insight;Interferons;Irritable Bowel Syndrome;late life;Life;Link;long term hospitalization;Lung;lung development;Lung immune response;lung injury;Macrophage;Mediating;Mentors;microbial;microbiome;microbiome alteration;Monoclonal Antibodies;Mus;neonatal immune system;neonatal mice;neutralizing antibody;neutrophil;Outcome;Parenteral Nutrition;pathogen;pediatric patients;Play;Population;Predisposition;Pregnancy;premature;Premature Infant;preventive intervention;pulmonary function;Regulatory T-Lymphocyte;resident commensals;respiratory;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Syncytial Virus Vaccines;Respiratory Tract Infections;response;Risk;Role;Shapes;Sphingolipids;Surface;Therapeutic;Tissues;trafficking;Transplantation;Vaccines;Viral;Work

PROJECT_TITLE: Defining the role of premature infant microbial dysbiosis in mediating immune development and response to infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-S (20)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Atherosclerotic cardiovascular disease is the leading cause of death in the industrialized world. Recent studies suggest that atherosclerotic plaques that are prone to causing clinical cardiac events are characterized by several features of defective resolution, including inefficient clearance of apoptotic cells. The goal of this project is to advance our understanding on the triggers that lead to failed resolution during chronic inflammation and uncover fundamental mechanisms of disease to treat atherosclerosis.

PI_NAMEs: GONZALEZ, AZUAH LUCRECIA (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Agonist;Anti-Inflammatory Agents;Apoptotic;Area;Arterial Fatty Streak;Atherosclerosis;Biological Response Modifiers;Ca(2+)-Calmodulin Dependent Protein Kinase;Cardiac;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cell Death;Cells;Chronic;Chronic Disease;chronic inflammatory disease;Clinical;Cues;cytokine;Data;Defect;Development;Disease;Epigenetic Process;Event;Exhibits;Exposure to;Failure;Genes;Goals;Hyperactivity;hypercholesterolemia;Immune;Immunity;Immunologic Memory;Immunological Models;Impairment;improved;In Vitro;in vivo;Individual;Industrialization;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Ingestion;Lesion;lipid mediator;Lipids;Macrophage;Mediator;Memory;Metabolic;Modification;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;Natural Immunity;Necrosis;novel;Outcome;oxidized low density lipoprotein;Pathway interactions;Patients;Phagocytosis;Phenotype;Play;prevent;Process;Production;programs;Protein-Serine-Threonine Kinases;Publications;Recurrence;Regulation;repaired;Resolution;response;Role;Scheme;Secondary to;Serine;Stimulus;Testing;therapeutic target;Therapeutically Targetable;Time;tissue repair;Training;uptake;Viral;western diet;Work

PROJECT_TITLE: CaMK4 as a Critical Mediator of Inflammation Resolution and Trained Immunity


NIH_SPENDING_CATS: Diabetes;Genetics;Human Genome;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: Narrative. Although genome-wide association studies have identified numerous genes and variants associated with diabetes, the exact biological functions of these genes/variants in human pancreatic β cells are largely unknown. Here, we will use human embryonic stem cells, human islets, and humanized mice to systematically study the role of these genetic variants in human pancreatic β cell development, function, and survival in vitro and in vivo. Understanding the biological functions of these genes/variants will significantly enhance our knowledge of β cell biology, which will pave the way for the development of drugs for precision therapy for diabetes patients.

PI_NAMEs: CHEN, SHUIBING  (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Affect;Alleles;Apoptosis;ATAC-seq;Beta Cell;Binding;Biological Process;Cell Death;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cell Survival;cell type;Cells;Cellular biology;Cellular Stress;D Cells;Death Rate;Diabetes Mellitus;diabetes mellitus therapy;Disease;drug development;Endocrine;endocrine pancreas development;Environmental Risk Factor;Fatty Acids;gene function;Generations;Genes;Genetic;genetic variant;genome wide association study;Glucose;Goals;Human;human disease;human embryonic stem cell;human embryonic stem cell line;human model;humanized mouse;Impairment;improved;In Vitro;in vivo;inhibitor;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;islet;Knock-out;knockout gene;Knowledge;Ligands;MADH2 gene;member;Molecular;mouse development;mouse model;Mus;Mutation;Nature;neonatal diabetes mellitus;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Outcome;overexpression;Pancreas;pancreas development;Pathway interactions;Patients;Pharmaceutical Preparations;Population;Precision therapeutics;Proliferating;promoter;Proteins;Reporting;Resources;Risk;Role;Signal Transduction;Single Nucleotide Polymorphism;single-cell RNA sequencing;Structure of beta Cell of islet;System;Testing;theories;therapy development;transcriptome sequencing;Transforming Growth Factor beta;type I and type II diabetes;Variant;VTCN1 gene;Zinc Fingers

PROJECT_TITLE: Role of GLIS3 in Human Pancreatic Beta Cell Generation, Survival and Proliferation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Drug Abuse (NIDA only);Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Social Determinants of Health;Substance Misuse

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Effective, long-lasting therapies are urgently needed to combat psychiatric disorders involving dysregulated reward circuitry, such as depression and disordered eating. Psychedelic drugs have recently gained traction for their efficacy in treating depression, and potential as a therapeutic for disordered eating. The experiments in this proposal will examine the effectiveness of psychedelic drugs at reversing changes to reward-seeking behavior induced by early-life adversity.

PI_NAMEs: LAWSON, KATE A (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: addiction;Adult;Affect;Agonist;Anhedonia;Animal Model;Animals;Anorexia Nervosa;Anxiety;Basic Science;Beds;Behavior;behavior prediction;Behavioral;Behavioral Assay;Behavioral Model;Binge Eating;Binge eating disorder;Biological;Brain;Brain region;Childhood;Clinical Trials;combat;Consumption;Data;depression model;Development;Disease;Dose;drug action;drug efficacy;early life adversity;Early treatment;Eating;Eating Disorders;effective therapy;effectiveness evaluation;efficacy evaluation;Environment;experience;experimental study;Female;Food;FOS gene;Goals;Hallucinogens;high reward;HTR2A gene;Human;Individual;insight;Life;low socioeconomic status;male;Measures;Memory impairment;men;Mental Depression;Mental disorders;Modeling;Nature;neglect;neural;neural network;neural patterning;neuronal patterning;novel therapeutics;Persons;Pharmaceutical Preparations;Phenotype;Population Heterogeneity;Procedures;Psilocybin;Psychiatry;Psychopathology;Rattus;receptor;Recording of previous events;reward circuitry;Rewards;Risk;Rodent;Rodent Model;Serotonin;sex;side effect;stem;Stress;Testing;Therapeutic;Therapeutic Effect;Traction;Trauma;Treatment Protocols;Woman

PROJECT_TITLE: Efficacy of psychedelic drugs at reversing aberrant reward-seeking behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prevention;Urologic Diseases

ORG_CITY: CHICAGO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE 5-hydroxymethylcytosine(5hmC) is an epigenetic modification that serves as a stable marker of DNA demethylation and transcriptional activation. To date, the role of 5hmC regulation in a number of diseases has only been explored using plasma cell-free DNA samples. By comprehensively characterizing 5hmC profiles derived from both healthy urine cfDNA and bladder cancer urine cfDNA, this proposal aims to nominate urine cfDNA as a viable and noninvasive liquid biopsy alternative for genitourinary cancers.

PI_NAMEs: PANDA, ARPIT  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Address;Benchmarking;bioinformatics pipeline;Biological;Biological Markers;biomarker development;Bladder;Bone Marrow;cancer diagnosis;Cancer Patient;cancer therapy;Cell Differentiation process;cell free DNA;Clinics and Hospitals;Colon;Cystectomy;Data;demethylation;Deposition;Detection of Minimal Residual Disease;Development;Diagnosis;Diagnostic;diagnostic biomarker;Disease;DNA;DNA analysis;Early Diagnosis;Enhancers;Enzymes;Epigenetic Process;epigenomics;Excision;Family;Future;Gene Expression;gene repression;Genes;Genetic Transcription;Genitourinary system;genome-wide;Genomic DNA;Genomics;Homeostasis;human tissue;insight;Kidney;large cell Diffuse non-Hodgkin's lymphoma;Libraries;liquid biopsy;lymph nodes;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;minimally invasive;Modeling;Modification;Monitor;multiple omics;Mutation;Operative Surgical Procedures;Outcome;Pancreas;Performance;Physiological;Plasma Cells;Play;Population;predictive marker;predictive signature;Preparation;Prevention;Primary carcinoma of the liver cells;Process;prognostic;Prognostic Marker;promoter;Prostate;Regulation;Research;Research Personnel;Residual Neoplasm;Role;Sampling;Signal Transduction;Source;Specificity;Testing;therapeutic target;Tissues;tool;Transcriptional Activation;tumor;Urine;Urogenital Cancer;Urogenital Diseases;Variant;Work

PROJECT_TITLE: Unlocking the Diagnostic and Prognostic Potential of 5hmC in Urine cfDNA: Characterization of Genome-wide Landscape in Healthy Urine and Biomarker Development in Localized Bladder Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-Z (20)]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Public Health Relevance Atrial and ventricular cardiac arrhythmias, are serious public health problems in the United States, affecting over 5% of Americans and are major causes of stroke and heart failure leading to increased morbidity and mortality. This proposed preclinical study and clinical trial will determine how electromechanical wave imaging, a non- invasive ultrasound precision imaging modality can effectively diagnose and determine the mechanism of the arrhythmia and impact personalized treatment of cardiac arrhythmias.

PI_NAMEs: BIVIANO, ANGELO ;KONOFAGOU, ELISA E.;WAN, ELAINE Y (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: 3-Dimensional;Ablation;Adolescent;Adopted;Adult;Affect;aging population;American;anatomic imaging;Anatomy;Anticoagulation;Apical;Area;Arrhythmia;Atrial Flutter;Atrial Premature Complexes;Atrial Tachycardia;Biomedical Engineering;Biometry;Bypass;Cardiac;Cardiac ablation;Cardiac Electrophysiologic Techniques;Clinical;clinical research site;Clinical Trials;Consumption;cost;Coupling;Data;Decision Making;density;design;Diabetes Mellitus;Diagnosis;diagnostic accuracy;Diagnostic tests;diagnostic value;Echocardiography;Electrocardiogram;Electrophysiology (science);grasp;Heart;Heart Atrium;Heart failure;hemodynamics;high dimensionality;Hypertension;Image;image guided;imaging modality;Imaging Techniques;improved;improved outcome;innovation;Laboratories;Lateral;Lead;Left;Lesion;Location;Magnetic Resonance Imaging;Maps;Medical center;Morbidity - disease rate;mortality;multidisciplinary;non-invasive imaging;noninvasive diagnosis;Outcome;patient population;Patient Schedules;Patients;Pattern;personalized medicine;Persons;Physicians;portability;preclinical study;Procedures;prospective;Public Health;public health relevance;Radiation;Randomized;randomized trial;randomized, clinical trials;Recommendation;Recurrence;Reproducibility;Resolution;secondary analysis;standard of care;Stroke;Techniques;Technology;Therapeutic;Time;tool;Ultrasonography;ultrasound;United States;Universities;Ventricular;Ventricular Premature Complexes;Ventricular Tachycardia;virtual;Visualization;Wolff-Parkinson-White Syndrome;X-Ray Computed Tomography

PROJECT_TITLE: Precision imaging of electromechanical coupling for non-invasive cardiac arrhythmia mapping

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pain Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Although Spanish-speaking Latinx children are at a particularly high risk for experiencing pain management disparities in the Emergency Department (ED) due to linguistic barriers, very little is known about sociocultural factors that contribute to misaligned pain understanding during interpreted medical encounters. This mixed methods design research study aims to identify sociocultural factors that influence interpreted pain communication and evaluate the concordance of pain understanding among multiple stakeholders (caregivers, children, interpreters, and clinicians) in a linguistically and ethnically diverse sample of children who present to the ED with pain-related complaints. The information gained from this research will contribute to the budding knowledgebase on culturally relevant pain assessment and management for language-diverse patients and families who use interpretation services in pediatric medical settings, thereby promoting development of future interventions and equitable health services for historically underserved youth.

PI_NAMEs: LIM, PAULINA  (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: 6 year old;Academy;Accident and Emergency department;Acculturation;Acute;Address;Age;American;Anxiety;Area;Award;Belief;California;career;career development;Caregivers;Caring;Child;Childhood;Clinical Research;Cohort Studies;college;Communication;Country;County;Data;Development;Dimensions;Discrimination;Disparity;early-career faculty;Emergency Department Physician;Environment;ethnic diversity;Ethnic Population;Evaluation;experience;Family;Foundations;Fright;Funding;Future;Goals;Guidelines;Health;health care disparity;Health Disparities Research;health disparity;health equity;Health Services;High Prevalence;high risk;Home;improved;Injury;innovation;interdisciplinary approach;Intervention;Interview;Joints;K-Series Research Career Programs;knowledgebase;Language;Latinx;Latinx population;Leadership;Linguistics;Medical;Mentors;Mentorship;Methodology;Methods;minority health;minority health disparity;multidisciplinary;National Institute on Minority Health and Health Disparities;Needles;nonEnglish language;Operative Surgical Procedures;Oranges;Pain;Pain management;Pain Measurement;Parents;patient population;Patients;pediatric department;pediatric emergency;Pediatric Hospitals;Pediatrics;Play;Policies;population health;Populations at Risk;post-traumatic symptoms;Postdoctoral Fellow;Procedures;Process;Productivity;programs;psychologic;psychological outcomes;racial population;Recording of previous events;Reporting;Research;Research Design;Research Ethics;Research Methodology;research study;Risk;Role;Sampling;Services;skills;social culture;sociocultural determinant;Spanish;stakeholder perspectives;Stress;Training;United States National Institutes of Health;Universities;Youth

PROJECT_TITLE: Evaluating pain communication and understanding in interpreted medical encounters in a pediatric emergency department

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


PHR: Project Narrative:  Recently it has been identified that in IPF, one of the main characteristics is the loss of alveolar epithelial type II stem cells (AT2), with the concurrence appearance of transitional AT2 cells, an undetermined aberrant alveolar epithelial. We have identified a decrease in the expression and activity of CPT1a, a limiting regulator of fatty acid oxidation (FAO), which results in increased transitional AT2 stem cells without reaching a terminal AT1 differentiation, consequently decreasing the resilience against lung fibrosis. In this grant, we will address for the first time the functional role of FAO, one of the critical mitochondrial metabolic pathways.

PI_NAMEs: MORA, ANA LUCIA (contact);ROJAS, MAURICIO

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;Acyl Coenzyme A;Age;age related;age-related disease;Aging;AGTR2 gene;airway epithelium;Alveolar;alveolar epithelium;alveolar homeostasis;Appearance;Architecture;Area;biological adaptation to stress;Carnitine Palmitoyltransferase I;Catabolic Process;Cell Aging;Cell Differentiation process;cell immortalization;Cell Line;cell regeneration;Cells;Cellular Metabolic Process;Cellular Stress;Characteristics;Cicatrix;Data;decrease resilience;Defect;Development;disease prognosis;Distal;DNA Damage;Energy-Generating Resources;Enzymes;Epigenetic Process;epigenetic regulation;Epithelial Cells;Epithelium;Exhibits;fatty acid oxidation;Fatty Acids;Fibrosis;Gene Expression;Genes;Genetic;genetic signature;Genetic Transcription;Grant;Histone Acetylation;Histones;Human;human tissue;idiopathic pulmonary fibrosis;in vivo;Injury;interstitial;Keratin;KRT19 gene;Link;lipid metabolism;Lung;lung development;Lung Diseases;lung regeneration;Metabolic;Metabolic Pathway;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Mitochondrial Membrane Protein;Mus;Natural regeneration;Nuclear;Outer Mitochondrial Membrane;overexpression;Pathologic;Pathway interactions;Predisposition;Process;programs;Protein Acetylation;Protein Isoforms;Pulmonary Fibrosis;Regulation;repaired;resilience;response;Role;Signal Transduction;single-cell RNA sequencing;stem cells;Structure of parenchyma of lung;Supplementation;Testing;Time;Tissues;tool;transcriptional reprogramming;Transforming Growth Factor beta;wound healing

PROJECT_TITLE: Regulation of Repair Responses in the Lung by Fatty Acid Oxidation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-E (03)]


ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE --------------------------------------------- -------- ---- The signs of manganese (Mn) toxicity are neurological and range from mood, cognitive to motor disorders; thus, it is critical to understand how excess metal deposition from welding fumes affects different brain regions, and how these depositions are related to each other. Therefore, the goal of this research is to establish novel computational in vivo imaging methods to a) separately visualize and quantify excess Mn and Fe deposition in the individual welder brain, and b) characterize the propagation of Mn and Fe in the human brain and the role of different brain regions in the development of neurotoxicity effects with the aid of brain network science tools and advanced statistical methods.

PI_NAMEs: MONSIVAIS, HUMBERTO  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Address;Adverse effects;Affect;Alzheimer's Disease;Brain;Brain imaging;Brain Mapping;Brain region;career;Chromium;Chronic;Clinical;clinical imaging;Cognition;Cognitive;Cognitive deficits;cognitive performance;contrast enhanced;contrast imaging;Data Set;Deposition;Development;Diagnosis;Disease Progression;Early Diagnosis;Elements;Ensure;Environment;Exclusion;Exposure to;farmer;Gadolinium;Goals;Health;healthy volunteer;Homeostasis;Human;human data;Image;Imaging Device;imaging modality;Imaging technology;in vivo;in vivo imaging;Individual;Industry;Inhalation Exposure;innovation;interest;Ions;Iron;Knowledge;Knowledge acquisition;Liver Cirrhosis;Magnetic Resonance Imaging;Manganese;Manganism;Maps;Measurement;Measures;Mediation;Metal exposure;Metals;Methods;Modeling;Monitor;Moods;Motor;motor deficit;motor disorder;neurobehavioral;neurochemistry;Neurodegenerative Disorders;neuroimaging;Neurologic;Neurologic Dysfunctions;neuron loss;Neuropsychology;neurotoxic;neurotoxicity;novel;Outcome;Oxidative Stress;Parenteral Nutrition;Parkinson Disease;particle;Patients;Policies;Predisposition;prevent;Process;psychologic;Recording of previous events;Research;Risk;Role;Science;Screening procedure;Spatial Distribution;Statistical Methods;Structure;Symptoms;Techniques;Technology;Technology Assessment;Testing;Time;Tissues;tool;Toxic effect;toxic metal;toxicant;Trace metal;translational impact;treatment response;uptake;Visualization;Visualization software;Welding

PROJECT_TITLE: Quantitative MRI and Network Science Applications in Manganese Neurotoxicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ADMINISTERING_IC: NS

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Genetics;Neurosciences;Pain Research

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The neural mechanisms underlying affective pain in the brain are relatively unexplored compared to pain mechanisms in the periphery. Preliminary work has identified a C57 subline, C57BL/10SnJ, that shows a novel affective pain phenotype of increased pain-linked escape behavior, that is correlated ith increased neural activity in the ventral lateral periaqueductal grey (vlPAG) and anterior cingulate cortex. This proposal will make use of C57BL/10SnJ mice and the genetic tools available in C57BL/6J mice to elucidate the neural mechanisms in the vlPAG that modulate pain-linked escape behavior.

PI_NAMEs: BURDGE, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Acute Pain;Affective;Afferent Neurons;Anterior;attenuation;Behavior;Behavioral;behavioral phenotyping;behavioral response;Brain;Brain region;brain shape;Calcium;calcium indicator;career;cell type;Chemicals;chronic pain;cingulate cortex;comparative;Evolution;Fiber;Gene Expression;Genes;Genetic;Genetic study;Genetic Variation;Glutamates;Human;Image;Immunohistochemistry;In Situ;in vivo;in vivo calcium imaging;Knowledge;Lateral;Learning;Link;Maps;Measures;Mechanics;Mediating;midbrain central gray substance;Mouse Strains;Mus;neural;neuromechanism;Nociception;nociceptive response;novel;Opsin;Pain;pain behavior;Pain Disorder;Pain management;Pain Research;pain sensation;pain sensitivity;Panic;Pathway interactions;Peripheral;Peripheral Nervous System;peripheral pain;Persistent pain;Phenotype;Photometry;Population;Reporting;Research;Research Personnel;response;RNA;Role;Specificity;Stimulus;Testing;Therapeutic;therapeutic target;tool;Tracer;Translating;Variant;Viral;Virus;Wild Type Mouse;Work

PROJECT_TITLE: Elucidating the Role of the vlPAG in Novel Pain-linked Escape Behavior Using C57 Sublines

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]