ACTIVITY: ZIG

NIH_SPENDING_CATS: Biomedical Imaging;Mental Health

PI_NAMEs: ALLEN-WORTHINGTON, KRYSTAL  (contact)

PROJECT_TERMS: Accreditation;Administrative Personnel;Anesthesia procedures;animal care;Animal Care and Use Committees;Animal Husbandry;animal imaging;Animal Technicians;Animals;Bite;Breeding;Caring;Communities;comparative;Contractor;Contracts;Derivation procedure;Development;Disease;environmental enrichment for laboratory animals;Euthanasia;Government;Guidelines;Hamsters;Healthcare;Hemorrhage;Hour;Human Resources;Injections;International;Intramural Research Program;Laboratory Animal Science;Laboratory Animals;Laws;Magnetic Resonance Imaging;Maryland;Medical;Medical Research;Medicine;Mission;model development;Mus;National Institute of Mental Health;nonhuman primate;Operative Surgical Procedures;Participant;pathology imaging;Phenotype;Play;Policies;policy recommendation;Positioning Attribute;Positron-Emission Tomography;Preparation;Prevention;Principal Investigator;programs;Protocols documentation;radiological imaging;Rattus;Regulation;Research;Research Personnel;Research Support;restraint;Rodent;Role;Running;sample collection;Services;Techniques;Time;Training;United States National Institutes of Health;Veterinarians;Veterinary Medicine;Weaning

PROJECT_TITLE: Veterinary Medicine Research Branch


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

PI_NAMEs: NARVER, HEATHER  (contact)

PROJECT_TERMS: Accreditation;Amendment;animal care;Animal Care and Use Committees;animal facility;Animals;Behavioral;Biomedical Research;Callithrix;Callithrix jacchus jacchus;Caring;Censuses;Charge;Clinical;Genetic Enhancement;Health;Human Resources;Image;Knowledge;Laboratories;Laboratory Animals;Lead;Macaca;Mission;National Center for Complementary and Integrative Health;National Institute of Neurological Disorders and Stroke;National Institute on Deafness and Other Communication Disorders;Nervous System;Nervous System Disorder;Neurosciences Research;nonhuman primate;operation;physical conditioning;Process;programs;Protocols documentation;Research Support;Rodent;therapy development;Training;Veterinarians

PROJECT_TITLE: Animal Care Program


ACTIVITY: ZIJ

ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health

ORG_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

PI_NAMEs: CLARK, JANET  (contact)

PROJECT_TERMS: American Indians;Anniversary;Applications Grants;Archives;Authorship;Award;Behavior;Black race;Brain;career;Certification;Chalk;Clinical;Clinical Psychology;cohort;Collaborations;college;Communication;Communities;community building;Development;Doctor of Philosophy;Drops;Education;Educational Curriculum;Educational workshop;Ethics;Evaluation;Event;experience;Faculty;Feedback;Feeds;Fees;Fellowship;Foundations;Funding;Funding Mechanisms;graduate research fellowship program;graduate student;Grant;health disparity;Holly;Human Resources;Hybrids;Individual;International;Interview;Intramural Research;Intramural Research Program;Joints;K-Series Research Career Programs;Lead;lectures;LinkedIn;London;Mediation;Medical Students;meetings;member;Mental Health;Mentors;multidisciplinary;Museums;National Center for Advancing Translational Sciences;National Institute of Dental and Craniofacial Research;National Institute of Drug Abuse;National Institute of General Medical Sciences;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National Institute on Deafness and Other Communication Disorders;Neurosciences;Persons;Phase;post-pandemic;Postbaccalaureate;Postdoctoral Fellow;posters;pre-doctoral;Principal Investigator;Privatization;Prize;Process;programs;Psychology;Publications;recruit;Research;Research Ethics;Research Personnel;Research Training;Resources;responsible research conduct;Running;Science;Scientific Advances and Accomplishments;Scientist;Series;Services;skills;social media;Societies;statistics;Students;summer internship;Surveys;symposium;Time;Training;training opportunity;Training Programs;Twitter;United States National Institutes of Health;Universities;virtual;Visit;Vocational Guidance;volunteer;Woman;Writing

PROJECT_TITLE: Office of Fellowship Training


ACTIVITY: ZIK

PI_NAMEs: WONG, JENNIFER  (contact)

PROJECT_TERMS: Affect;Agreement;Area;Behavior;Biomedical Research;Brain;Clinical Trials;Collaborations;Complement;Cooperative Research and Development Agreement;Counseling;Creativeness;data integration;Databases;Development;Disclosure;Employee;Extramural Activities;Gifts;Goals;Human Resources;improved;innovation;interest;invention;Legal patent;Licensing;material transfer agreement;Mediation;member;Mental Health;Mind;Mission;Monitor;National Institute of Mental Health;Policies;Privatization;Procedures;Reporting;Research Personnel;Secure;Services;Technology Transfer;United States National Institutes of Health;working group

PROJECT_TITLE: Office of Technology Transfer


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biomedical Imaging;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases

ORG_CITY: FREDERICK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

ORG_STATE: MD

PI_NAMEs: OSBORNE, C.K.  (contact)

PROJECT_TERMS: Address;Adult;Adverse event;Age;Animals;Antibodies;antiretroviral therapy;attenuation;Biodistribution;CD4 Antigens;CD4 Lymphocyte Count;Common Terminology Criteria for Adverse Events;Deferoxamine;FDA approved;Half-Life;HIV;HIV drug resistance;HIV Infections;HIV-1;Human;IgG4;Image;imaging capabilities;Imaging technology;immune reconstitution;immunogenicity;Immunologist;in vivo;in vivo imaging;intravenous administration;lymph nodes;Lymphocyte Count;Lymphoid Tissue;Macaca;Matched Group;Measures;Mediating;Methods;Monoclonal Antibodies;Multi-Drug Resistance;Mus;National Institute of Allergy and Infectious Disease;nonhuman primate;open label;optical imaging;Patient Schedules;Patients;peripheral blood;Pharmaceutical Preparations;phase I trial;Photons;Positron;Positron-Emission Tomography;Production;programs;Quality Control;quantitative imaging;Radioimmunoconjugate;Radiolabeled;Recombinants;Reporting;Resolution;Rodent Model;Safety;Scientist;serial imaging;simian human immunodeficiency virus;single photon emission computed tomography;Site;SIV;Spleen;T-Cell Depletion;T-Lymphocyte;Tissues;trafficking;Visualization;whole body imaging;Zirconium

PROJECT_TITLE: Non-Invasive In Vivo Imaging of CD4 pool in HIV-1 Infected Patients


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: FOUTS, TIMOTHY  (contact)

PROJECT_TERMS: AIDS prevention;Contractor;Contracts;Development;Documentation;flexibility;HIV vaccine;Investigational Drugs;Investigator-Initiated Research;Modality;National Institute of Allergy and Infectious Disease;Phase;preclinical development;Preclinical Testing;Process;Production;research clinical testing;research study;Support Contracts

PROJECT_TITLE: NIAID Preclinical Development Support: Essential Core Activities


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Pediatric

ORG_CITY: ROCKVILLE

ORG_NAME: FISHER BIOSERVICES, INC.

PI_NAMEs: MARTIN, BRITTANY  (contact)

PROJECT_TERMS: Address;Age;Bar Codes;Best Pharmaceuticals for Children Act;Biological Specimen Banks;Blood;Cells;Child;Childhood;Conduct Clinical Trials;Congresses;Contracts;Data;dose information;Drug Prescriptions;Dryness;Ensure;Equipment and supply inventories;Erythrocytes;Formulation;Funding;Goals;Human;Human Milk;improved;Knowledge;Label;Modification;Monitor;National Institute of Child Health and Human Development;Online Systems;Orphan;Pharmaceutical Preparations;Pharmacologic Substance;Plasma;repository;Research;Safety;Sampling;Serum;Services;Specimen;Spottings;System;Testing;Therapeutic;Tube

PROJECT_TITLE: NICHD HUMAN BIOSPECIMEN REPOSITORY- REPOSITORY SERVICES FOR THE BEST PHARMACEUTICALS FOR CHILDREN ACT (BPCA) AND PEDIATRIC TRIALS NETWORK (PTN)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Mental Health

ORG_CITY: WILMINGTON

ORG_NAME: PPD DEVELOPMENT LP

ORG_STATE: NC

PI_NAMEs: KIRBY, MATTHEW  (contact)

PROJECT_TERMS: Clinical Research;clinical research site;Funding;Institution;Leadership;Monitor;National Institute of Mental Health;Recommendation;Research;research study;Services;Site

PROJECT_TITLE: CLINICAL RESEARCH AND STUDY MONITORING SUPPORT FOR NIMH STUDIES


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PI_NAMEs: LUTZ, CATHLEEN  (contact)

PROJECT_TERMS: Advocacy;Affect;Alzheimer's Disease;American;Aneuploidy;Animal Model;Artificial Chromosomes;base;Basic Science;Behavioral Research;biobehavior;Biological Models;Biology;Body System;Breeding;Centromere;Chromosome 16;Chromosome 21;Chromosomes;Clinical Trials;cohort;Communities;community engagement;Contractor;Contracts;Cryopreservation;Cytogenetics;Development;Disease;disease model;Dissection;Down's Syndrome;Educational workshop;Embryo;embryo cryopreservation;Ensure;Epidemiology;Etiology;Female;Fertility;Functional disorder;Genes;Genetic;Germ Cells;high reward;high risk;Human;Human Chromosomes;Human Genome;human model;humanized mouse;Implant;Individual;Intellectual functioning disability;interest;Investigation;Investments;Late Onset Alzheimer Disease;life span;Maintenance;male;meetings;Methods;Modeling;Molecular;mouse genome;mouse model;Mouse Strains;mouse Trisomy 16;mouse Ts65Dn;Mus;National Institute of Child Health and Human Development;Participant;PPBP gene;prenatal;preservation;prevent;Prevention;Procedures;Production;programs;Qualifying;repository;Research;Research Personnel;Research Training;Resources;screening;Study models;Synteny;telomere;trait;Translational Research;transmission process;Trisomy;United States National Institutes of Health

PROJECT_TITLE: REPOSITORY OF MOUSE MODELS FOR CYTOGENETIC RESEARCH


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Uterine Cancer;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PI_NAMEs: MUTCH, DAVID G (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Advocacy;Advocate;Amendment;Bioinformatics;Biometry;Biostatistics Core;Body System;Budgets;career;Caring;Clinical Trials;Collaborations;Committee Members;Communication;Conduct Clinical Trials;Contracts;Decision Making;Development;Documentation;Electronics;Endometrial;Endometrial Carcinoma;Enrollment;Ensure;Equity;Ethics;Fostering;Goals;Grant;Human Resources;innovation;Institution;Institutional Review Boards;Instruction;Malignant Neoplasms;meetings;metabolomics;mindfulness;Mission;National Cancer Institute;New Mexico;Newsletter;next generation;Oklahoma;operation;Participant;Pathology;Patients;payment;programs;Progress Reports;Publications;Reporting;Research;Research Personnel;Route;Services;Site;Specialized Program of Research Excellence;success;Sum;Time;Underrepresented Minority;Universities;Washington;web site

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Pediatric;Precision Medicine;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The All of Us Research Program is building a cohort of over a million individuals who consent for the use of their data and biospecimens for health-related research. The Coast-to-Coast (C2C) Consortium is composed of a set of healthcare provide organizations that help All of Us recruit, retain, and facilitate interactions with the populations cared by their health systems.

PI_NAMEs: BOROWSKY, ALEXANDER D;GOODMAN, MARC T;HIATT, ROBERT A;KIM, SUE ELIZABETH;MEEKER, DANIELLA ;MONTALVO-ORTIZ, JANITZA LIZ;OHNO-MACHADO, LUCILA  (contact);SILVA, AMARILYS ;SITAPATI, AMY MONTAGUE

PROGRAM_OFFICER_NAME: ALEXANDER-TROUPE, STEPHANIE MELANIA

PROJECT_TERMS: Absenteeism at work;All of Us Research Program;Area;Awareness;Biomedical Research;Blood Banks;California;Catchment Area;Childhood;Church;Clinic;clinical infrastructure;clinical research site;Collaborations;collaborative environment;Collection;Communication;Communities;Community Healthcare;community organizations;community partners;Complement;Computers;Connecticut;Consent;Contract Services;cost;cost estimate;Costs and Benefits;Country;Creativeness;Data;data dictionary;data exchange;data sharing;Decision Making;Disease;Doctor of Philosophy;Education;Electronic Health Record;Enrollment;Equilibrium;ethnic minority population;Ethnic Origin;Ethnic Population;Event;experience;Faith-based organization;Geography;Goals;Grant;Growth;Health;Health Insurance Portability and Accountability Act;Health Personnel;Health system;Healthcare;Helping to End Addiction Long-term;Hot Spot;implementation science;improved;Income;Information Technology;Infrastructure;innovation;Institution;Internet;Joints;Knowledge;Latinx;Leadership;Learning;lens;Life Cycle Stages;literacy;Location;Low income;male;Marketing;Measurement;Medical center;member;Mission;Modeling;Monitor;multidisciplinary;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;outreach;outreach program;Participant;patient outreach;Patient Schedules;Patients;pediatrician;Persons;Population;Population Heterogeneity;Poverty;Precision Health;precision medicine;precision nutrition;Process;programs;Provider;Public Health;Puerto Rico;Qualifying;Race;racial minority population;racial population;recruit;Research;Research Institute;retention rate;Retrieval;Rhode Island;Rural;rural area;rural setting;safety net;Schedule;Site;skills;Socioeconomic Status;socioeconomics;Spanish;Speed;success;Support Groups;System;Training;Underserved Population;United States;United States National Institutes of Health;Universities;urban setting;volunteer;Vulnerable Populations;wireless fidelity;Work;Youth

PROJECT_TITLE: Enhancing All of Us through the Targeted Enrollment of Opioid Use Disorder Special Populations


FUNDING_MECHANISM: SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Microbiome;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: ONCOBIOMIX INC.

ORG_STATE: TX

PI_NAMEs: LEACH, CHARLES  (contact)

PROJECT_TERMS: adverse outcome;Area;Assessment tool;Awareness;Bioinformatics;Biological Assay;Biopsy;cancer diagnosis;cancer initiation;cancer risk;CLIA certified;Clinical;Clinical Research;Collection;commercialization;Consent;cost;Custom;Data;Decentralization;Decontamination;detection limit;Development;Diagnosis;DNA;Early Diagnosis;Enrollment;exhaust;experience;experimental study;Feasibility Studies;Feedback;Freezing;global health;gut microbiota;Human;Human Microbiome;improved;in silico;innovation;insight;Instruction;Laboratories;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;microbiome;microbiome research;microbiome signature;novel;Online Systems;Participant;Patients;Performance;Phase;Procedures;Process;prostate cancer risk;Protocols documentation;PSA screening;quality assurance;Quality Control;recruit;Reference Standards;Reporting;Reproducibility;Research;Research Design;Risk Assessment;Role;Running;sample collection;Sample Size;Sampling;screening;Small Business Innovation Research Grant;Specificity;Specimen;Standardization;stool sample;Surveys;synthetic construct;Target Populations;Technology;Testing;Time;tool;tumor progression;United States;Validation;Visit;web site

PROJECT_TITLE: TOPIC NUMBER: 458 SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE IONCOBIOMIX: MICROBIOME-BASED TEST FOR PROSTATE CANCER RISK


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE  In this study, we developed a first-in-class small-molecule inhibitor of EZH2, a protein enzyme that has been demonstrated by a myriad of studies to drive cancer development and progression. Instead of the C-terminal catalytic domain that current EZH2-targeting drugs interfere with, our compound binds to an N-terminal domain that is essential for the enzymatic activity-independent oncogenic effect of EZH2 in certain types of cancer cells, like estrogen receptor a-negative (ERa-) breast cancer cells. Therefore, our prototype compound retarded the growth of ERa- breast cancer cells that are insensitive to present EZH2 inhibitors. Results from our work will yield a new class of anticancer agents that specifically target a totally different functional domain of EZH2, which hold promise for broader clinical applications than current EZH2-targeted therapies.

PI_NAMEs: XU, KEXIN  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Adverse event;Affinity;Aggressive behavior;analog;anti-cancer therapeutic;Antineoplastic Agents;Binding;Biological;Biological Assay;Breast Cancer Cell;Breast Cancer Model;Breast Epithelial Cells;C-terminal;cancer cell;cancer type;Cancerous;Catalytic Domain;cell growth;Chemicals;Chromatin;Clinical;clinical application;Competence;Complex;Computer Assisted;Computer-Aided Design;design;Development;Disease;Drug Targeting;efficacy evaluation;Enzymes;ESR1 gene;Exhibits;EZH2 gene;Failure;FDA approved;Gene Activation;Gene Expression Profiling;gene repression;Gene Silencing;Genes;genetic inhibitor;Genetic study;Genetic Transcription;Goals;Growth;high throughput screening;Histone H3;histone methylation;histone methyltransferase;Histones;Human;Impairment;improved;in silico;in vivo;inhibitor;Instruction;Lead;Lysine;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;malignant phenotype;Mediating;Methylation;migration;Monitor;mouse model;mutant;Mutation;Myeloproliferative disease;N-terminal;Neoplasm Metastasis;novel;novel anticancer drug;Oncogenic;overexpression;Patients;Play;Polycomb;predictive modeling;Proliferating;Proteins;prototype;Reporting;Research;Research Personnel;Role;Second Primary Cancers;SET Domain;side effect;Signal Pathway;Site;small molecule inhibitor;Structure;Structure-Activity Relationship;targeted agent;targeted treatment;therapy resistant;Toxic effect;Transactivation;Transcription Coactivator;tumor;Tumor Cell Migration;tumor progression;Tumor Promotion;tumorigenesis;Tumorigenicity;Work;X-Ray Crystallography;Xenograft procedure

PROJECT_TITLE: Development of a new class of EZH2 inhibitors in ERa-negative breast cancer


ACTIVITY: ZIA

ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PI_NAMEs: SZABO, ATTILA  (contact)

PROJECT_TERMS: Address;Affect;Area;Behavior;Biological Process;biological systems;Catalysis;Cells;Chemical Dynamics;chemical reaction;cold shock protein;Collaborations;Color;Data;Development;Diffusion;Enzymes;Equilibrium;experimental study;Fluorescence;Fluorescence Resonance Energy Transfer;Fluorescence Spectroscopy;G-substrate;Goals;Individual;Investigation;Kinetics;laser tweezer;Lasers;light emission;light intensity;macromolecule;Measures;Methods;Microscopic;Molecular Conformation;Nature;novel;Nuclear Magnetic Resonance;Output;Paper;Parameter Estimation;Performance;Photons;physical process;Play;Population;Process;protein folding;Proteins;Publications;Publishing;Relaxation;Reporting;Research;Scanning Probe Microscopes;Selection Bias;Selection Criteria;single molecule;Spottings;Structure;Theoretical Studies;theories;time interval

PROJECT_TITLE: Theoretical Studies On The Dynamic Aspects Of Macromolecular Function


ORG_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PI_NAMEs: KOPP, JEFFREY BURNETT (contact)

PROJECT_TERMS: Affect;African American population;African ancestry;AIDS-Associated Nephropathy;APOL1 gene;Blood Vessels;cell type;Cells;Cicatrix;Classification;Clinical;differential expression;Disease;Focal and Segmental Glomerulosclerosis;Genes;Genetic;genetic variant;Genetic Variation;HIV;Hyperplasia;Hypertrophy;Incidence;Individual;Interferon Type II;Keloid;Kidney Diseases;Mus;Obesity;Pathologic;PF4 Gene;podocyte;Proteins;Recurrence;Renal Mass;renal toxin;Sickle Cell Anemia;Syndrome;transcriptomics;Transgenic Mice;Variant

PROJECT_TITLE: Focal Segmental Glomerulosclerosis: Genetics & Mechanisms


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases;Kidney Disease;Rare Diseases

PI_NAMEs: HEYMANN, JURGEN  (contact)

PROJECT_TERMS: absorption;Affect;Aftercare;AIDS-Associated Nephropathy;APOL1 gene;Apoptosis;Biology;Cell Proliferation;Cells;Classification;Clinical;Data;Desmin;Differentiation Antigens;Distal;Distal convoluted renal tubule structure;Double-Stranded RNA;End stage renal failure;Epithelium;Focal and Segmental Glomerulosclerosis;Genes;Genetic;genetic variant;glomerulosclerosis;HIV;HIV-1;HIV/AIDS;Hyperplasia;Hypertrophy;Hyponatremia;Individual;Injury;Kidney;kidney cortex;Kidney Diseases;Mediating;Messenger RNA;Mineralocorticoid Receptor;mitochondrial dysfunction;Molecular;mouse model;Mus;Nephrons;Obesity;Oxidative Phosphorylation;Parietal;Pathogenesis;Pathologic;Pathway interactions;Patients;Phenotype;podocyte;PRKR gene;Protein Kinase;Proteins;Proteinuria;Renal Mass;renal toxin;response;Risk;risk variant;Role;sensor;Sickle Cell Anemia;single nucleus RNA-sequencing;SLC12A3 gene;Sodium;Sodium Chloride;South Africa;STAT protein;STAT3 gene;symporter;synaptopodin;Syndrome;System;Tetracyclines;transcriptome sequencing;transcriptomics;transgene expression;Transgenic Mice;Tubular formation;Variant;Viral Proteins;Virus Diseases;vpr Gene Products;wasting

PROJECT_TITLE: Focal segmental glomerulosclerosis: HIV-associated nephropathy


NIH_SPENDING_CATS: Kidney Disease;Rare Diseases

PROJECT_TERMS: Africa South of the Sahara;Agonist;AIDS-Associated Nephropathy;Cells;cellular targeting;Chronic Kidney Failure;Data;Disease;Focal and Segmental Glomerulosclerosis;Functional disorder;global health;HIV;Injury;Intervention;Investigation;Kidney;Laboratory Study;metabolomics;mitochondrial dysfunction;Molecular;multiple omics;Mus;Niacinamide;Nicotinamide adenine dinucleotide;nicotinamide-beta-riboside;novel therapeutics;Pathogenesis;Pathway interactions;podocyte;Production;receptor;Role;Testing;Transgenic Mice;Tubular formation

PROJECT_TITLE: Focal segmental glomerulosclerosis: Treatment


PI_NAMEs: HINSHAW, JENNY E (contact)

PROJECT_TERMS: Alleles;Binding;Biological;Biological Assay;Cell membrane;Cells;Centronuclear myopathy;Charcot-Marie-Tooth Disease;Chemicals;Clathrin;Clathrin Adaptors;Clathrin Light Chains;Collaborations;Complex;constriction;cost;Coupled;Cryo-electron tomography;Cryoelectron Microscopy;Cytoskeleton;Defect;density;Devices;Disease;Drosophila genus;Dynamin;Dynamin I;Electron Microscopy;Elements;Endocytosis;Environment;Enzymes;Event;F-Actin;falls;Family member;Freezing;Funding;gang;Grant;GTP Binding;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Homologous Gene;Human;Hydrolysis;insight;Ion Channel;Length;Link;Lipid Bilayers;Lipid Binding;Lipids;Liposomes;Mammalian Cell;Mediating;member;Membrane;Membrane Proteins;Methods;millisecond;Modeling;Molecular Conformation;mutant;Mutation;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;Nature;Neck;New York;novel;Nutrient;overexpression;Pathway interactions;Peripheral Nervous System Diseases;PH Domain;Phosphatidylinositol 4,5-Diphosphate;phosphatidylinositol 4-phosphate;Phospholipids;Play;Polymers;Positioning Attribute;Preparation;Protein Family;Proteins;receptor;Recycling;Resolution;Role;Sampling;shibire gene product;Signal Transduction;Signaling Protein;Speed;structural biology;Structure;Synapses;Synaptic Membranes;Synaptic Vesicles;Temperature;Testing;three dimensional structure;Time;timeline;Tooth Diseases;trafficking;Tube;Vesicle;Work

PROJECT_TITLE: Structure And Function Of Dynamin, A 100kd GTPase Involved In Endocytosis


PROJECT_TERMS: Autosomal Dominant Optic Atrophy;Binding;Biogenesis;Biological;Biological Assay;Biological Process;Blindness;C-terminal;Cell Physiology;Cells;Characteristics;Childhood;Chloroplasts;Collaborations;Crista ampullaris;Cryoelectron Microscopy;Crystallography;Dimerization;Docking;Dynamin;Electrons;Endocytosis;Equilibrium;Event;Exhibits;Family member;Future;Goals;GTP Binding;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Hydrolysis;Inner mitochondrial membrane;insight;Integral Membrane Protein;Knock-in;Lead;Length;Lipid Bilayers;Lipids;Liposomes;Mammalian Cell;Maps;Mediating;Membrane;Membrane Fusion;Microscopy;Mitochondria;mitochondrial membrane;Molecular Conformation;Morphology;mutant;Mutation;Nature;Nucleotides;OPA1 gene;Organelles;Outer Mitochondrial Membrane;particle;Plants;Property;protein complex;Protein Family;Proteins;proteoliposomes;Resolution;Role;self assembly;SNAP receptor;Structure;Testing;Time;Transmembrane Domain;Viral Physiology;Visualization;Work

PROJECT_TITLE: Structural analysis of dynamins involved in mitochondrial morphology


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Pediatric;Physical Activity;Prevention

PI_NAMEs: CHEN, KONG  (contact)

PROJECT_TERMS: 3-Dimensional;Adult;African American;Age;Agreement;Area;Basal metabolic rate;biological adaptation to stress;Blood;Body Composition;Body measure procedure;Body Surface Area;Body Temperature;Brown Fat;Child;Childhood;Clinical;clinical center;Clinical Protocols;Clinical Research;CLN3 gene;Clothing;Control Groups;Data;design;developmental disease;Dietary intake;Disease;Dual-Energy X-Ray Absorptiometry;Energy Intake;Energy Metabolism;environmental change;Equation;Ethnic Origin;Expenditure;Fasting;Fatty acid glycerol esters;Female;fighting;Food;Goals;healthy volunteer;Heart Rate;Hour;Human;improved;Indirect Calorimetry;Inherited;Inpatients;interest;Intervention;Lasers;male;Measurement;Measures;men;Metabolic;military operation;Movement;Natural History;Nervous System;novel strategies;Obesity;obesity development;Participant;Patients;PET/CT scan;Phase;Physical activity;Positron-Emission Tomography;Postbaccalaureate;Process;programs;Protocols documentation;Publications;Publishing;Race;Randomized;Regulation;Research;response;Rest;Role;Shivering;skeletal dysplasia;Skeletal Muscle;Skin;Techniques;Temperature;Thermogenesis;Thinness;Training;United States National Institutes of Health;urinary;volunteer;Weight;Women's cohort;X-Ray Computed Tomography

PROJECT_TITLE: Development of obesity and metabolic clinical research programs


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

PI_NAMEs: LEAPMAN, RICHARD  (contact)

PROJECT_TERMS: 3-Dimensional;A kinase anchoring protein;Area;Biological;Brain;Brain imaging;Cell membrane;Cell Nucleus;Cells;Complex;Cryoultramicrotomy;Cysteine;Darkness;Data;Dendritic Spines;density;detection sensitivity;detector;DLG4 gene;Dose;Drug Metabolic Detoxication;Elasticity;Electron Beam;Electron energy loss spectroscopy;Electron Microscope;Electron Microscopy;electron tomography;Electrons;Elements;Endosomes;Epoxy Resins;Exocytosis;Face;Fluorescence;fluorescence imaging;Freeze Drying;Freeze Substitution;Freezing;frontier;Gallium;Golgi Apparatus;Hippocampus;Image;imaging approach;imaging modality;Implant;implementation facilitation;interest;Ions;knock-down;Knowledge;Label;Laboratories;lens;Magnetic Resonance Imaging;Manganese;Maps;Measurement;Measures;meter;Methods;Microscope;Microscopy;Microtome - medical device;Microtomy;Modernization;Mutate;Mutation;N-terminal;nanometer;nanoprobe;nanoscale;Neurons;Neurosciences;novel;Optics;Organelles;palmitoylation;Penetration;Photons;postsynaptic;Proteins;Rattus;reconstruction;Regulation;Reporting;Resistance;Resolution;Roentgen Rays;sample fixation;Sampling;Scanning;Scanning Electron Microscopy;Series;Serine;Signaling Protein;Slice;Source;Specimen;Stains;Structure;Subcellular structure;Surface;Synapses;Synaptic plasticity;Techniques;Testing;Thick;three dimensional structure;Time;tissue preparation;Tissues;tomography;Trace Elements;trafficking;Transmission Electron Microscopy;transmission process;uptake;Vesicle;Visualization;Work;X ray spectroscopy

PROJECT_TITLE: Scanning Transmission Electron Tomography of Biological Structures


NIH_SPENDING_CATS: Bioengineering;Hematology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases;Regenerative Medicine;Sickle Cell Disease

ORG_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

PROJECT_TERMS: 3-Dimensional;Address;Adherence;Adopted;Alpha Granule;Animals;Arkansas;Atherosclerosis;Autoimmune Diseases;automated segmentation;Binding;Biogenesis;Biological;Biological Assay;biological systems;Blood coagulation;blood damage;Blood donor;Blood Platelets;Blood Vessels;Cardiovascular Diseases;Carotid Arteries;cell dimension;cell fixing;Cell Line;Cells;cellular imaging;Cellular Morphology;Chemoreceptors;chronic inflammatory disease;Clinical;Coagulation Process;Collaborations;Collagen;Computing Methodologies;convolutional neural network;Coupled;COVID-19;COVID-19 complications;COVID-19 patient;Data;deep learning;density;Diabetes Mellitus;Diagnostic;Diamond;Electron Microscope;Electron Microscopy;electron tomography;Electrons;Endothelial Cells;Endothelium;Evaluation;experience;Exposure to;Face;Gallium;Glass;Growth;Healthcare;Hemoglobin;Hemorrhage;Hemostatic function;Hospitalization;Human;Image;Implant;In Situ;Individual;inhibitor;injured;Injury;Ions;Kentucky;Knock-out;Laboratories;Lateral;Lead;Link;Liver;Liver neoplasms;LOC118430 gene;Lung;Machine Learning;Malignant Neoplasms;Mechanics;Medical;meter;Methodology;Methods;Mitochondria;Modeling;Molecular;Monitor;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;Mutation;nanometer;nanoscale;National Institute of Biomedical Imaging and Bioengineering;Obesity;optical imaging;Organelles;Phase;Physiological;Platelet Activation;Platelet aggregation;prevent;Process;Proteinase-Activated Receptors;Proteins;Puncture wound;radioresistant;receptor;reconstruction;recruit;Reporting;Resolution;respiratory;response;Scanning;Scanning Electron Microscopy;Science;Series;Sickle Cell;Sickle Cell Anemia;Signal Transduction;Site;Solid;Specimen;Stains;Statistical Data Interpretation;Structure;Structure of jugular vein;Surface;System;Techniques;Thinness;Three-Dimensional Image;Thrombin;Thrombosis;thrombotic;Thrombus;Time;tissue reconstruction;Tissues;Translating;transmission process;Tunica Adventitia;ultra high resolution;Ultramicrotomy;Universities;Vascular Diseases;vascular injury;Work

PROJECT_TITLE: Three-Dimensional Cell and Tissue Reconstruction by Serial Block Face SEM


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Cooley's Anemia;Hematology;Orphan Drug;Patient Safety;Rare Diseases;Sickle Cell Disease

PI_NAMEs: HAUGABOOK, SHARIE  (contact)

PROJECT_TERMS: absorption;Adhesions;Adult;Anemia;beta Globin;beta Thalassemia;Birth;Blood Vessels;Brain;Canada;Cell Death;Cessation of life;Chronic disability;Clinical;Clinical Pharmacology;Clinical Trials;Compensation;Data;Defect;Development;dimer;Disease;Drug Interactions;Drug Kinetics;drug repurposing;effective therapy;efficacy study;Erythrocytes;European Union;Excretory function;Fatigue;fetal;Fetal Hemoglobin;Formulation;Genes;Genetic Diseases;Goals;Health;Heart;Hemoglobin;Hemoglobin A;Hemoglobin concentration result;Hemoglobinopathies;Investigational Drugs;Investigational New Drug Application;Lead;Lung;manufacture;Metabolism;Mutation;Organ;Oxygen;Pharmaceutical Preparations;Pharmacology Study;Phase;Point Mutation;Polymers;Production;Proteins;Recommendation;Sampling;Sickle Cell Anemia;Sickle Cell Trait;Symptoms;targeted treatment;thalassemia intermedia;Therapeutic;Therapeutics for Rare and Neglected Diseases;Toxicology;United States Food and Drug Administration

PROJECT_TITLE: Repurposing an EU Therapeutic for Hemoglobinopathies


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

PI_NAMEs: HUANG, WENWEI  (contact)

PROJECT_TERMS: Affect;Africa South of the Sahara;analog;Animals;Anti-malarials;Biological Assay;Bite;Chills;Culicidae;Data;design;Development;Diarrhea;Disease;Dose;Drug Kinetics;Evaluation;Fever;FRAP1 gene;Goals;Headache;Human;improved;in vivo;Infection prevention;Lead;lead optimization;Lipids;Malaria;malaria infection;malaria transmission;Modeling;mosquito-borne;Myalgia;National Center for Advancing Translational Sciences;novel drug class;Oral;Organ;Parasite Control;Parasites;Parasitic Diseases;Patients;Persons;Pharmaceutical Preparations;Phosphotransferases;Pilot Projects;Plasmodium falciparum;Preparation;Property;Recovery;reduce symptoms;Rodent;Scientist;Series;Sweating;Symptoms;Testing;Time;Toxicology;transmission blocking;transmission process;Vomiting;Work

PROJECT_TITLE: Development of Malaria Transmission-Blocking Drugs


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Cancer;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: ZHENG, WEI  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;ACE2;Action Potentials;Affect;Alagille Syndrome;Animal Model;anti-cancer;Anti-viral Agents;antiviral drug development;Area;Artificial Intelligence;artificial intelligence method;artificial intelligence model;assay development;Axon;Binding;Biological Models;Biotechnology;Brain;cancer cell;cancer drug resistance;Cardiac Myocytes;Cell Differentiation process;Cell Line;cell type;Cells;Cessation of life;chemotherapy;Clinical;Clinical Data;Clinical Treatment;Clinical Trials;Collaborations;Collection;colon cancer cell line;Communication;Computer Models;computerized;cost;COVID-19;Data;Data Analyses;Development;Disease;disease mechanisms study;disease model;disease phenotype;dopaminergic neuron;Drug Costs;drug development;drug discovery;drug efficacy;Drug Industry;drug repurposing;Drug resistance;Drug Targeting;Drug toxicity;experience;experimental study;Fluorouracil;frontier;Generations;Genetic;Genetic Diseases;Goals;Heparitin Sulfate;Hepatocyte;high throughput screening;Human;human induced pluripotent stem cells;Impairment;In Vitro;in vitro Assay;Incidence;induced pluripotent stem cell;induced pluripotent stem cell technology;Industry;Intellectual functioning disability;laboratory experiment;Lead;Length;Libraries;Liver;Malignant Neoplasms;Manuscripts;Medicine;Midbrain structure;Modeling;Motor Neurons;National Center for Advancing Translational Sciences;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;neglect;Neuromuscular Junction;neuron development;Neurons;Neuropathy;new technology;new therapeutic target;novel;novel strategies;novel therapeutics;Organoids;Pathogenesis;patient derived induced pluripotent stem cells;Patients;Pharmaceutical Preparations;Phenotype;Platinum;Positioning Attribute;pre-clinical;Process;Protocols documentation;Publications;Publishing;rare genetic disorder;receptor;refractory cancer;Research Personnel;Resources;RNA Viruses;Sampling;SARS-CoV-2 entry inhibitor;SARS-CoV-2 spike protein;screening;Screening procedure;standard care;stem cells;Study models;System;Therapeutic;therapeutic candidate;therapeutic evaluation;Therapeutics for Rare and Neglected Diseases;Time;Training;United States National Institutes of Health;Universities;Viral;viral entry inhibitor;Viral Proteins;virtual;virtual screening;Virus;Work

PROJECT_TITLE: Drug Repurposing Screening for Rare and Neglected Diseases


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

PI_NAMEs: OTTINGER, ELIZABETH  (contact)

PROJECT_TERMS: Abdominal Pain;Anatomy;Biological Products;biomaterial compatibility;blood perfusion;Clinical;Clinical Research;Clinical Trials;controlled release;design;effective therapy;Formulation;Generations;Genes;Goals;Greater sac of peritoneum;imaging agent;Indwelling Catheter;Infection;Intercellular Fluid;intraperitoneal;intraperitoneal therapy;Intravenous;intravenous administration;Lead;Malignant neoplasm of pancreas;manufacture;Oncology;Oral Administration;Paclitaxel;particle;Particle Size;Patients;Penetration;Peritoneal;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;Polymers;pressure;prevent;Property;randomized trial;Research Personnel;small molecule therapeutics;Solid Neoplasm;System;Systemic Therapy;Toxic effect;Toxicology;tumor;vector;Work

PROJECT_TITLE: Studies of Tumor-Penetrating Microparticles for Pancreatic Cancer


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

PI_NAMEs: MATHÉ, EWY  (contact)

PROJECT_TERMS: Area;authority;Breathing;Categories;Chemical Structure;Chemicals;Classification;clinical investigation;Clinical Trials;Code;Collaborations;Computer software;Country;Data;data exchange;data modeling;Data Set;Disease;DNA Sequence;Drug Industry;Drug or Chemical;Electronics;Environment;Evaluation;Event;Future;global health;Goals;Health;improved;Information Systems;International;Language;Life Cycle Stages;Marketing;Medicine;Modeling;Names;National Center for Advancing Translational Sciences;Pharmacologic Substance;pharmacovigilance;Phase;Plants;post-market;Process;Production;Proteins;Research;Research Personnel;Safety;Scientist;software development;software systems;Source;Staging;Standardization;Structure;supply chain;System;Technology;Terminology;United States Food and Drug Administration;Work

PROJECT_TITLE: Global Substance Registration System


NIH_SPENDING_CATS: Infectious Diseases

PROJECT_TERMS: Area;Case Report Form;Case Study;Cellular Phone;Clinical;clinical practice;Collaborations;collaboratory;Collection;Communicable Diseases;Communities;COVID-19;COVID-19 pandemic;Critical Pathways;crowdsourcing;Data;Data Collection;Development;Disease;Dose;drug candidate;drug development;drug repurposing;Drug usage;Electronic Health Record;experience;Fostering;handheld mobile device;Health Personnel;Health Professional;Human;individual patient;Internet;Intervention;Legal;Life;Marketing;Medical;Medical Device;Monkeypox;National Center for Advancing Translational Sciences;neglect;novel;novel therapeutics;Outcome;Pathway interactions;Pharmaceutical Preparations;Pilot Projects;Population;Reporting;repository;Research;Resources;Sarcoma;Societies;Therapeutic;United States Food and Drug Administration;United States National Institutes of Health;web site;World Health Organization

PROJECT_TITLE: CURE ID App for Infectious Disease Case Reporting


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Code;Communities;Comprehension;Data;Data Aggregation;Data Set;Databases;Development;Drug Targeting;Funding;Future;G-Protein-Coupled Receptors;Generations;Genome;Informatics;informatics tool;Ingestion;interest;Ion Channel;Knowledge Management Center;Maintenance;Malignant Neoplasms;mouse model;Pathway interactions;Phase;Phosphotransferases;Process;programs;Protein Family;Proteins;Publications;Research;Research Personnel;Resources;Source;Technology;Update;web portal;web site;Work

PROJECT_TITLE: Knowledge Management Center for Illuminating the Druggable Genome


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: TAWA, GREGORY  (contact)

PROJECT_TERMS: Affect;Animals;B-Lymphocytes;Bioinformatics;Biological Markers;Biology;biomarker validation;Blood;cancer cell;canine model;Canis familiaris;cell killing;Cell Line;Cells;companion animal;comparative;Complex;data streams;Diagnosis;Disease;Drug Combinations;Exhibits;experimental study;gene conservation;Human;Lung Adenocarcinoma;Malignant Neoplasms;Melanoma;Methods;Modeling;multiple omics;Mus;Oncology;Osteosarcoma;patient derived xenograft model;Pharmaceutical Preparations;Proteins;Research;synergism;T-Cell Lymphoma;Testing;therapeutic candidate;Tissues;transcriptome sequencing;transcriptomics;trend;Work

PROJECT_TITLE: Canine models for characterization, diagnosis, and treatment of human cancers using comparative canine-human transcriptomics


NIH_SPENDING_CATS: Data Science

PROJECT_TERMS: Acceleration;Address;Biological;Biomedical Research;Cell Physiology;Chemicals;Clinic;Clinical;Clinical Data;Communities;Complex;Computer Assisted;computer scientist;computerized tools;computing resources;Data;data mining;data repository;data reuse;Data Scientist;Data Sources;data standards;data translator;design;Disease;disease classification;Disparate;Environmental Exposure;Etiology;Event;falls;Functional disorder;Generations;Genes;Goals;heterogenous data;Human;human disease;information gathering;insight;Knowledge;knowledge network;Left;Manuals;Medical;Molecular;multimodality;National Center for Advancing Translational Sciences;open source;Pharmaceutical Preparations;programs;Publishing;Research;Research Personnel;Resources;response;Scientist;Services;Signs and Symptoms;Source;Specific qualifier value;System;therapeutic development;tool;Translational Research

PROJECT_TITLE: NCATS Biomedical Data Translator


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Orphan Drug;Pediatric;Rare Diseases

PROJECT_TERMS: Address;Animal Model;Animals;assay development;Biotechnology;Capsid;Cell model;cellular development;Childhood;clinical center;clinical development;clinical lot;Clinical Protocols;Clinical Research;Clinical Trials;Cobalamin;Collaborations;Congenital Myasthenic Syndromes;cost;Dependovirus;design;Development;Development Plans;Disease;Documentation;efficacy study;efficacy testing;Engineering;experience;Feedback;Foundations;gene delivery system;gene product;gene therapy;Gene Transduction Agent;Genes;immunogenicity;improved;ketotic hyperglycinemia;Lead;lead candidate;Learning;manufacture;manufacturing process;manufacturing scale-up;meetings;Methods;methylmalonic aciduria;molecular pathology;National Center for Advancing Translational Sciences;National Human Genome Research Institute;National Institute of Child Health and Human Development;National Institute of Neurological Disorders and Stroke;Natural History;operation;Orphan Drugs;Paper;Patients;Pharmaceutical Preparations;Phase;Pilot Projects;pre-Investigational New Drug meeting;preclinical development;preclinical study;Preparation;Process;Production;programs;Rare Diseases;research clinical testing;Research Design;Safety;safety study;scale up;Scientist;Speed;Surrogate Markers;Technology;Testing;Therapeutic;Therapeutics for Rare and Neglected Diseases;Toxicology;United States National Institutes of Health;vector

PROJECT_TITLE: Gene Therapy Platform for Rare Diseases


NIH_SPENDING_CATS: Biotechnology;Machine Learning and Artificial Intelligence

PI_NAMEs: MARKOSSIAN, SARINE  (contact)

PROJECT_TERMS: Academia;Address;Area;Artificial Intelligence;Basic Science;Biological Assay;Biology;Biotechnology;Boston;California;Case Study;Chemicals;Chemistry;Communities;Cysteine;design;Discipline;Doctor of Medicine;Doctor of Philosophy;drug development;drug discovery;Drug Industry;editorial;Educational workshop;electronic book;Ensure;experience;Goals;Government;Guidelines;high throughput screening;Industry;innovation;International;Laboratories;Lead;Machine Learning;Manuals;Medical;member;Molecular Biology;National Center for Advancing Translational Sciences;novel therapeutics;outreach;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Physiological;pre-clinical;preclinical development;professor;programs;Proteins;Protocols documentation;Public Health;Research;Research Project Grants;Resources;Sampling;San Francisco;Science;Scientist;Series;Source;symposium;Technology;Therapeutic;Time;Training;Training and Education;Translational Research;translational scientist;Translations;Universities;Update;Vesnarinone;virtual;Waiting Lists;web site;webinar;Writing

PROJECT_TITLE: Assay Guidance Manual


NIH_SPENDING_CATS: Pain Research;Patient Safety;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: ROGERS, TRACEY  (contact)

PROJECT_TERMS: Acute Pain;Address;Animals;Antibodies;Autologous Transplantation;biodegradable scaffold;Biodistribution;Biological Response Modifier Therapy;BMP2 gene;BMP6 gene;bone;bone fracture repair;bone healing;Bone Malalignment;Bone Morphogenetic Proteins;Bone Regeneration;Bone Transplantation;Cell Differentiation Induction;Cell membrane;chronic pain;Clinical Trials;Complex;Data;Development;Disadvantaged;Dose;Drug Kinetics;efficacy evaluation;efficacy study;Evaluation;first-in-human;Fracture;Goat;Harvest;healing;Hemorrhage;Hospitalization;Human;Implant;in vivo;Inflammation;Injectable;Injury;Innovative Therapy;Investigational New Drug Application;Lead;long bone;manufacture;Medical;Mesenchymal Stem Cells;Methods;Morbidity - disease rate;new technology;Operating Rooms;Operative Surgical Procedures;Osteogenesis;Pain;Patient Compliance;Patient Recruitments;Patients;Pharmaceutical Preparations;Physiological;Pilot Projects;plasmid DNA;Plasmids;pre-clinical;preclinical development;Procedures;protein expression;Quality of life;Recombinant Proteins;regenerative healing;repaired;research clinical testing;Risk;Sampling;Scientist;Sheep;side effect;Site;sonoporation;Spine surgery;stem cells;Surgeon;Technology;Time;tissue stem cells;Toxicology;ultrasound;United States;United States Food and Drug Administration;Weight-Bearing state

PROJECT_TITLE: Targeted Bone Regeneration via Activation of Resident Stem Cells


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Orphan Drug;Pediatric;Rare Diseases

PROJECT_TERMS: Adult;Agonist;Animals;autosome;Blood;bone;Bone Matrix;Calcium;calcium absorption;Childhood;Chronic;Clinical;clinical center;Clinical Trials;Coupled;Defect;Development;Disease;Documentation;Drug Kinetics;Epiphysial cartilage;Equilibrium;Excretory function;first-in-human;Formulation;Generations;Goals;good laboratory practice;Good Manufacturing Process;Grant;GTP-Binding Proteins;Heterozygote;Hypercalcemia;Hypophosphatemia;improved;In Vitro;in vivo evaluation;inorganic phosphate;Investigational New Drug Application;Ions;juvenile animal;Kidney;Lead;Ligands;long bone;manufacture;Measures;Metaphyseal chondrodysplasia;Methods;Minerals;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Natural History;Orphan Drugs;Patients;pediatric patients;Peptides;Pharmaceutical Preparations;Phase I Clinical Trials;Phase II Clinical Trials;Phenotype;Physiology;preclinical development;preclinical study;Preparation;Process;Proteins;Qualifying;Rare Diseases;Rattus;receptor;research clinical testing;Safety;Sampling;Scientist;Signal Transduction;skeletal;skeletal abnormality;Skeletal Development;Standardization;Testing;Therapeutics for Rare and Neglected Diseases;Toxicology;Transgenic Mice;United States National Institutes of Health;Validation;Vitamin D

PROJECT_TITLE: A Treatment for Patients with Jansens Metaphyseal Chondrodysplasia (JMC)


NIH_SPENDING_CATS: Genetics;Rare Diseases

PROJECT_TERMS: Advocate;anti-cancer research;bioinformatics resource;Biomedical Computing;Clinical;Clinical Data;Collaborations;Computational Science;computing resources;Data;Data Analyses;Data Collection;Data Correlations;data resource;Dedications;Development;Diagnosis;Disparate;Farber's lipogranulomatosis;Genetic;Genetic Predisposition to Disease;genetic variant;Genome;Genomics;Genotype;Goals;improved;Individual;Informatics;insight;interactive visualization;Laboratories;Literature;Manuals;Mining;Modeling;National Cancer Institute;Pathogenicity;Patients;Phenotype;programs;Publications;Publishing;Rare Diseases;Research Personnel;Software Framework;Source;text searching;therapeutic development;therapy development;tool;Update;Variant;web app

PROJECT_TITLE: Developing an Integrated Rare Disease Bioinformatics Resource to Determine Phenotype to Genotype Correlations


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases

PROJECT_TERMS: Animals;Bioinformatics;Biological;bisulfite sequencing;Brain Neoplasms;cancer type;candidate marker;Canis familiaris;Cell Cycle;companion animal;comparative;Data;Disease;diverse data;DNA Methylation;Erinaceidae;Exhibits;FOXM1 gene;Genes;Genetic;Glioma;Goals;Histiocytic sarcoma;Histologic;Histopathologic Grade;Human;IL2 Signaling Pathway;Immune;Inflammatory;Location;Malignant Neoplasms;meningioma;Methods;Modeling;Oncology;Ontology;Pathway interactions;Pharmaceutical Preparations;Research;RNA analysis;Sampling;Spinal;Structure of choroid plexus;therapeutic target;transcriptome sequencing;tumor;whole genome

PROJECT_TITLE: Genetic Characterization of Canine Brain Tumors


NIH_SPENDING_CATS: Cannabinoid Research;Natural Products;Neurosciences;Physical Injury - Accidents and Adverse Effects;Substance Misuse

PROJECT_TERMS: absorption;Acute;acute symptom;Agonist;antagonist;Anxiety;Auditory Hallucination;Beverages;Binding;Brain;cannabinoid administration;cannabinoid receptor;Cannabinoids;Cannabis;Chemicals;Clinical;clinical material;Clinical Research;Clinical Trials;CNR1 gene;Consumption;Data;Development;Dose;Drug Kinetics;Emergency Care;Evaluation;Flowers;Food;Formulation;Goals;Hospitalization;Hour;improved;Individual;Inhalation;Injectable;Intramuscular Injections;intravenous injection;Investigational New Drug Application;Lead;Marijuana;medical attention;Medical emergency;Nausea;Oral Administration;Overdose;Paranoia;Pharmacodynamics;Plants;pre-clinical;preclinical development;Psychotropic Drugs;receptor;Reporting;Research;research clinical testing;Route;Scientist;Smoke;Smoking;Symptoms;synthetic cannabinoid;synthetic marijuana;Tetrahydrocannabinol;Therapeutic;tool;Toxicology;Visual Hallucination

PROJECT_TITLE: Development of Drinabant for Treatment of Acute Cannabinoid Overdose


PROJECT_TERMS: 3-Dimensional;Academia;acute toxicity;Affect;aging population;Algorithms;American;Amyotrophic Lateral Sclerosis;animal data;Animal Experiments;Animal Testing;Animals;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Area;assay development;Benchmarking;Biological Assay;Biological Sciences;bioprinting;Biotechnology;cell type;Cells;Central Nervous System;Cessation of life;Chemical Structure;Clinic;Clinical;clinical center;Clinical Trials;Clinical Trials Design;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Competence;cost;cost efficient;Data;design;Development;Diagnosis;Disease;Dose;drug development;drug discovery;Drug Industry;effective therapy;empowerment;experimental study;first-in-human;Foundations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Future;Gene Delivery;gene therapy;Gene Therapy Agent;gene-targeted therapy;Genes;Goals;Human;improved;In Vitro;in vitro Assay;in vivo;individualized medicine;Induced pluripotent stem cell derived human neuron;Informatics;innovation;Laboratories;Lead;lipid nanoparticle;manufacture;manufacturing facility;meetings;Methods;Modality;Motor Neurons;Mus;Mutation;nanoparticle;National Center for Advancing Translational Sciences;National Institute of Neurological Disorders and Stroke;neglect;Nerve Degeneration;Neurodegenerative Disorders;Neurons;new technology;novel;novel strategies;novel therapeutics;oligonucleotide delivery;Oral;Organoids;Patients;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;Phase;Population;prediction algorithm;predictive modeling;Process;Productivity;Property;prospective;Rare Diseases;Research;Research Personnel;Resources;Respiratory Failure;RNA;Route;Safety;scale up;screening;side effect;Small Interfering RNA;Speed;Standardization;System;targeted treatment;Technology;technology platform;Testing;Therapeutic;therapeutic RNA;Time;timeline;Tissues;Toxic effect;Toxicology;United States National Institutes of Health;Universities;uptake;Work

PROJECT_TITLE: Antisense Oligonucleotide (ASO) Development for Rare and Neglected Diseases


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Lung;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Acceleration;assay development;Biological Assay;Clinical;clinical candidate;clinical development;clinical efficacy;Clinical Investigator;Communities;COVID-19;COVID-19 pandemic;COVID-19 therapeutics;COVID-19 treatment;COVID-19 vaccine;Data;Data Collection;data portal;Data Set;Deposition;Development;drug development;Drug Kinetics;drug metabolism;drug repurposing;efficacy testing;Formulation;Government;GS-441524;Human;Industry;Leadership;manufacture;model development;Mutation;National Center for Advancing Translational Sciences;Neutralization Tests;open data;particle;Pharmaceutical Preparations;pharmacokinetic model;Positioning Attribute;preclinical development;Productivity;Protocols documentation;Public Health;public-private partnership;Research;Resources;response;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Scientist;screening;sharing platform;Standardization;therapeutic development;Therapeutic Intervention;therapeutic vaccine;Toxicology;United States National Institutes of Health;Vaccinated;Vaccines;Variant;Viral Physiology;Work

PROJECT_TITLE: COVID-19: Identification and Development of Clinical Candidates to Treat SARS-CoV-2


PROJECT_TERMS: Adverse effects;Aerobic;Affect;Amikacin;Aminoglycoside Antibiotics;Aminoglycosides;analytical method;Antibiotic Therapy;Antibiotics;Auditory;capsule;Cessation of life;clinical research site;Data;design;Disease;Dizziness;Drug Interactions;Drug Kinetics;efficacy evaluation;Encapsulated;Equilibrium;Excipients;Formulation;Hair Cells;hearing impairment;Human Volunteers;Impairment;Infection;Inner Hair Cells;Labyrinth;manufacture;mycobacterial;Natural Killer Cells;Oral;ototoxicity;Patients;Pharmaceutical Preparations;phase I trial;Phase II Clinical Trials;phase II trial;pre-clinical;Preparation;prevent;prevent hearing loss;Safety;side effect;small molecule;Validation;vestibular system

PROJECT_TITLE: Developing ORC-13661 for Preventing Aminoglycoside Antibiotics-induced Hearing Loss


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

PROJECT_TERMS: Acceleration;Acute Pain;Address;Analgesics;Binding;blood-brain barrier crossing;Brain;Chronic;chronic pain management;Clinical Trials;delta opioid receptor;Dependence;Discipline;drug action;drug repurposing;drug seeking behavior;efficacy study;Encapsulated;endogenous opioids;Enkephalins;first-in-human;Formulation;Genetic;Helping to End Addiction Long-term;high throughput screening;Human Biology;human model;In Vitro;in vivo;Infrastructure;Intranasal Administration;Investigational New Drug Application;Leucine Enkephalin;manufacture;Methods;Molecular;mu opioid receptors;National Center for Advancing Translational Sciences;non-cancer chronic pain;novel;novel therapeutics;Opioid;opioid epidemic;opioid use disorder;Pain;pain model;pain relief;Peptide Hydrolases;Peripheral;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Plasma;Play;preclinical development;preclinical study;Prodrugs;Role;safety assessment;Science;side effect;Technology;Testing;therapeutic candidate;therapeutic development;Toxic effect;Toxicology;United States Food and Drug Administration;United States National Institutes of Health;Ventilatory Depression

PROJECT_TITLE: Fast, Centrally Acting, Non-Addicting Novel Analgesic for Chronic Non-Cancer Pain


NIH_SPENDING_CATS: Chronic Pain;Complementary and Integrative Health;Fentanyl Misuse and Addiction;Natural Products;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

PROJECT_TERMS: Acceleration;Address;ADME Study;Agonist;Alkaloids;Asia;Buprenorphine;capsule;Clinical;clinical investigation;Clinical Research;Clinical Trials;Controlled Clinical Trials;Data;Development Plans;Discipline;Drug Administration Schedule;Drug Interactions;Drug Kinetics;drug metabolism;drug repurposing;Fentanyl;first-in-human;Formulation;Helping to End Addiction Long-term;Heroin;high throughput screening;Human Biology;human model;In Vitro;Infrastructure;Investigational Drugs;Investigational New Drug Application;manufacture;meetings;Mitragyna;mu opioid receptors;National Center for Advancing Translational Sciences;novel therapeutics;Opioid agonist;opioid epidemic;opioid use disorder;opioid withdrawal;Pain;pain relief;Pharmaceutical Preparations;Pharmacologic Substance;Play;pre-clinical;pre-Investigational New Drug meeting;preclinical development;preclinical study;Process;Production;research clinical testing;respiratory;Risk;Role;Science;Sodium Chloride;Standardization;Testing;Therapeutic;therapeutic candidate;therapeutic development;Toxicokinetics;Toxicology;United States Food and Drug Administration;United States National Institutes of Health

PROJECT_TITLE: Developing a Mitragynine Formulation to Conduct Rigorously Controlled Clinical Trials with a Kratom Alkaloid Extract


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Orphan Drug;Rare Diseases;Women's Health Research

PROJECT_TERMS: Ablation;ADME Study;Agonist;Behavior;biological systems;cancer immunotherapy;Cells;Clinical Trials;Development;Dose;drug distribution;Drug Kinetics;exhaust;Exhibits;Formulation;Future;Goals;Immune;immune modulating agents;Immunologics;Investigational New Drug Application;Malignant Neoplasms;Monoclonal Antibodies;Myeloid-derived suppressor cells;neoantigens;Organ;Pancreas;Perfusion;Phenotype;preclinical development;preclinical study;Preparation;programs;research clinical testing;Safety;small molecule;Solid;Stomach;T cell infiltration;T-Lymphocyte;Therapeutics for Rare and Neglected Diseases;Toxicology;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;Tumor-associated macrophages

PROJECT_TITLE: First-in-Class CD206 Agonist for Immunologically Cold Solid Organ Cancers


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Orphan Drug;Rare Diseases

PROJECT_TERMS: Address;Area Analyses;Attention;Biomedical Research;Clinical;clinical care;Collaborations;Communities;Disparity;Ensure;Equity;Funding;Future;Health;health disparity;health equity;Inequity;Intervention;Knowledge;lens;Outcome;outcome disparities;Phase;Play;pre-clinical;pre-clinical research;preclinical development;Process;Rare Diseases;Recommendation;research and development;Resources;Role;Science;Therapeutic;therapeutic candidate;therapeutic development;tool;Visualization

PROJECT_TITLE: Infusing Equity into Preclinical Research and Development


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

PROJECT_TERMS: Anabolism;Breast Adenocarcinoma;cancer subtypes;Cell Death;Chemicals;Coenzyme Q10;Digit structure;Exhibits;inhibitor;Malignant Breast Neoplasm;Malignant Neoplasms;Modeling;Mus;novel;p38 Mitogen Activated Protein Kinase;Pathway interactions;Pharmaceutical Chemistry;Phosphotransferases;Role;Series;SKBR3;Structure;Therapeutic Agents;therapeutic candidate;virtual screening

PROJECT_TITLE: Developing Therapeutic Candidates for Rare ADCK3-amplified Cancers


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Pain;Gene Therapy;Genetics;Nanotechnology;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Peripheral Neuropathy;Substance Misuse

PI_NAMEs: WU, EDWARD  (contact)

PROJECT_TERMS: Acceleration;Address;Affect;antagonist;Behavior;Brain;Central Nervous System;chronic pain management;Clinical Trials;Discipline;drug repurposing;efficacy study;Encapsulated;Endocytosis;Endosomes;Ensure;first-in-human;Formulation;G Protein-Coupled Receptor Signaling;Helping to End Addiction Long-term;high throughput screening;Human Biology;human model;inflammatory pain;Infrastructure;innovation;Investigational New Drug Application;knock-down;lipid nanoparticle;Mediator;nanoparticle;nanoparticle drug;nanopolymer;National Center for Advancing Translational Sciences;Neurotransmitters;novel therapeutic intervention;novel therapeutics;opioid epidemic;opioid use disorder;Pain;Pain management;painful neuropathy;Peripheral Nervous System;Play;Posterior Horn Cells;Postoperative Pain;preclinical development;preclinical study;Process;Production;RNA-targeting therapy;Rodent;Role;Science;Small Interfering RNA;Spinal Cord;Spinal cord posterior horn;Synaptic Transmission;Testing;Therapeutic;Therapeutic Agents;therapeutic candidate;therapeutic development;therapeutic siRNA;transmission process;United States Food and Drug Administration;United States National Institutes of Health;Work

PROJECT_TITLE: Targeting Endosomal GPCR (eGPCR) Signaling Platforms for the Treatment of Chronic Pain


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

PROJECT_TERMS: Acceleration;addiction;Address;antagonist;blood pressure elevation;Brain;Cardiac;Clinical;Clinical Research;Clinical Trials;Cocaine;Collaborations;craving;Development;Discipline;Dopamine;dopamine D3 receptor;drug of abuse;drug repurposing;drug seeking behavior;first-in-human;Helping to End Addiction Long-term;high throughput screening;Human Activities;Human Biology;human model;In Vitro;Infrastructure;Investigational Drugs;Investigational New Drug Application;Lead;mesolimbic system;National Center for Advancing Translational Sciences;National Institute of Drug Abuse;novel therapeutic intervention;novel therapeutics;Opioid;opioid epidemic;opioid use disorder;Oxycodone;Pain;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Play;Potassium Channel;Pre-Clinical Model;preclinical development;preclinical study;Production;Prosencephalon;receptor;Relapse;Rewards;Role;Science;Self Administration;Substance Use Disorder;System;Testing;therapeutic candidate;therapeutic development;Toxicology;United States Food and Drug Administration;United States National Institutes of Health

PROJECT_TITLE: Development of D3 Antagonist for Substance Use Disorder


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Chronic Pain;Emerging Infectious Diseases;Infectious Diseases;Natural Products;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Peripheral Neuropathy;Substance Misuse

PROJECT_TERMS: Acceleration;Address;Affect;Afferent Neurons;Animals;Attenuated;Biological Products;Body Weight;Botox;Botulinum Toxin Type A;Botulinum Toxins;Chemistry;Clinical Trials;Complex;cost effective;Development;Discipline;Drug Metabolic Detoxication;drug repurposing;first-in-human;Helping to End Addiction Long-term;high throughput screening;Human;Human Biology;human model;in vivo;Infrastructure;Investigational New Drug Application;manufacture;manufacturing process;National Center for Advancing Translational Sciences;nerve damage;neurotransmitter release;novel therapeutics;Opioid;opioid epidemic;opioid use disorder;Pain;pain relief;painful neuropathy;Paralysed;Pharmaceutical Preparations;Play;Population;preclinical development;preclinical study;Reporting;Rodent;Role;Safety;Science;side effect;Specificity;Testing;therapeutic candidate;therapeutic development;Therapeutic Uses;Toxic effect;United States Food and Drug Administration;United States National Institutes of Health

PROJECT_TITLE: Development of a Non-Paralyzing BoNT-based Biopharmaceutical for the Treatment of Neuropathic Pain


ACTIVITY: ZIC

NIH_SPENDING_CATS: Cannabinoid Research;Clinical Research;Complementary and Integrative Health;Dietary Supplements;Endocannabinoid System Research;Nutrition;Obesity;Physical Activity;Prevention;Rare Diseases;Women's Health Research

PROJECT_TERMS: 2-arachidonylglycerol;Acids;Acyl Coenzyme A;adipokines;Adipose tissue;Adult;Age;Air;Amber;amino acid metabolism;analytical method;anandamide;Arachidonic Acids;Attenuated;behavior test;Bezafibrate;Biological Markers;Body Composition;Body mass index;Body Temperature;Body Weight;Branched-Chain Amino Acids;Brown Fat;Calorimetry;Cardiovascular Diseases;Central obesity;Clinical;Clinical Protocols;Clinical Research;cold stress;Collaborations;cytokine;Data Analyses;Defect;Deposition;design;Diabetes Mellitus;Diet;dietary;Docosahexaenoic Acids;Drug or chemical Tissue Distribution;Dual-Energy X-Ray Absorptiometry;Eicosapentaenoic Acid;Endocannabinoids;Energy Metabolism;Exercise Test;Exhibits;experience;Fatty acid glycerol esters;Fatty Acids;fibroblast growth factor 21;fitness;Food;Genetic;Genetic Transcription;Health Benefit;Heart Rate;Hereditary Disease;Human;improved;Inflammatory;inflammatory marker;Inpatients;instrument;Length of Stay;Linoleic Acids;Lipodystrophy;Lipomatosis;Liver;Lower Extremity;Malignant Neoplasms;Measurement;Measures;Medical;Metabolic;methylmalonic aciduria;methylmalonyl coA mutase deficiency;migration;Modification;mouse model;Mus;National Human Genome Research Institute;National Institute on Alcohol Abuse and Alcoholism;novel;Obesity;Obesity Epidemic;obesity treatment;Omega-3 Fatty Acids;Outpatients;Overweight;oxidation;Patients;Pattern;Phenotype;Physical activity;Physiological;Physiology;Plasma;Population;portability;Premenopause;Publications;Randomized;Regulation;Reporting;Research;Research Activity;Research Design;Research Personnel;respiratory;response;Rest;Scientist;small molecule;Strategic Planning;subcutaneous;Syndrome;System;Temperature;Thermogenesis;Transgenic Organisms;United States National Institutes of Health;Upper Extremity;Visceral fat;Woman

PROJECT_TITLE: Human Energy and Body Weight Regulation Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: LECLAIR, CHRISTOPHER ARTHUR (contact)

PROJECT_TERMS: Acceleration;Acoustics;Address;Adopted;Adoption;Analytical Chemistry;analytical method;Anti-viral Agents;antiviral drug development;Appointment;Area;arm;Auranofin;Binding Proteins;Biocompatible Materials;Biological;Biology;Calibration;Career Choice;career development;Cells;Chemicals;Chemistry;Cholesterol;Chromatography;Circular Dichroism Spectroscopy;Collaborations;Collection;Communities;computer scientist;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 treatment;Data;data acquisition;Data Analyses;data management;Data Storage and Retrieval;design;Detection;Development;Disease;drug development;drug discovery;Education;Educational workshop;Emerging Technologies;Enhancers;Ensure;Enzymes;Equipment;Equipment and supply inventories;experience;Extramural Activities;Family;Goals;Gold;High Pressure Liquid Chromatography;high throughput screening;Hybrids;improved;Industry Standard;Injections;innovation;instrument;instrumentation;Intellectual Property;interest;kinase inhibitor;Knowledge;Laboratories;Learning;Libraries;Lipids;Liquid Chromatography;liquid chromatography mass spectrometry;Management Information Systems;Maryland;Mass Fragmentography;Mass Spectrum Analysis;medical schools;meetings;member;Mentorship;Methods;milligram;Mission;Modality;National Center for Advancing Translational Sciences;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;Nematoda;next generation;NMR Spectroscopy;novel;Nuclear Magnetic Resonance;Oral;pandemic disease;pandemic potential;Peer Review;Peptides;Performance;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phosphatidylcholine-Sterol O-Acyltransferase;Phosphotransferases;Postbaccalaureate;Postdoctoral Fellow;posters;pre-clinical;preclinical development;Preparation;Procedures;Process;process optimization;Productivity;professional atmosphere;programs;Proteins;Proteomics;Protocols documentation;Publications;rare condition;Reporting;Reproducibility;Research;Research Personnel;Research Project Grants;Resolution;Resources;Rheumatoid Arthritis;Robotics;Sampling;Schedule;Scientist;screening;screening program;Serum;Services;Site;small molecule;small molecule inhibitor;Supercritical Fluid Chromatography;symposium;System;Techniques;Technology;telework;Therapeutic;therapeutic candidate;therapeutic target;Time;Tissues;tool;Training;Translational Research;translational scientist;Tube;Universities;Vibrational Circular Dichroism;Viral;Virus;Water;Work

PROJECT_TITLE: Analytical Chemistry


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: MICHAEL, SAMUEL  (contact)

PROJECT_TERMS: Acoustics;Aptitude;arm;assay development;Astrocytes;Augmented Reality;Automation;Biological;Biological Assay;Biology;Biomanufacturing;Boston;Cancer Biology;cell bank;Cells;Chemical Structure;Chemicals;Clinical;Collaborations;Collection;Communities;Complex;Computer software;Country;Custom;Dana-Farber Cancer Institute;Data;Data Analyses;Databases;design;detector;Development;Device Designs;Devices;Dose;Drug Combinations;Emerging Technologies;Engineering;Equipment;Evaluation;Feedback;flasks;follow-up;Friends;high throughput screening;human induced pluripotent stem cells;Hybrids;Hypothalamic structure;Image;imager;improved;Incubators;induced pluripotent stem cell;instrument;instrumentation;Internet;Intramural Research Program;Laboratories;Libraries;Liquid substance;Maintenance;Measures;medical schools;member;Methods;Mission;National Center for Advancing Translational Sciences;Nature;Neurobiology;Neurons;Neurosciences;new technology;next generation;Nociceptors;operation;Patients;Pediatric Hospitals;Peripheral;Phase;preservation;Process;Production;Protocols documentation;Rare Diseases;Recording of previous events;Reporting;Research;Research Personnel;Research Support;Reservations;response;Retrieval;Robot;Robotics;Running;Sampling;scale up;Schedule;Scientist;screening;Services;Site;Small Business Innovation Research Grant;small molecule;Spottings;stem cells;System;Technology;Testing;Time;tissue culture;Training;trophoblast;Tube;Universities;Validation;Vial device;vigilance;Work

PROJECT_TITLE: Research Services Core (RSC)


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases

PROJECT_TERMS: Acceleration;Area;Bioinformatics;Biomedical Research;cheminformatics;Clinic;Clinical Data;complex data;Computational Biology;Computer software;Custom;Data;Data Analyses;Data Analytics;data modeling;Data Science;Data Set;Development;Ensure;Goals;Grant;high throughput screening;Informatics;insight;Knowledge;Maintenance;Mass Spectrum Analysis;Measurement;Methods;Mission;mobile application;Modeling;multidisciplinary;Multiomic Data;multiple omics;National Center for Advancing Translational Sciences;Natural Language Processing;Ontology;Outcomes Research;Publications;Rare Diseases;Research;research and development;Research Support;scientific computing;social media;software development;Source;Toxic effect;Translational Research;Translations;web app;Work

PROJECT_TITLE: Informatics Research


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Acceleration;Address;Affect;Agreement;Air;Algorithms;Analytical Chemistry;analytical method;application programming interface;Artificial Intelligence;Artificial Intelligence platform;Automation;Awareness;Benchmarking;Biological;Biological Assay;Biological Process;Biology;blockchain;chemical reaction;chemical synthesis;Chemicals;Chemistry;Chromatography;Cloud Computing;Collaborations;computational platform;Computer software;cooking;cost;dashboard;Data;Data Analyses;data management;data sharing;density;design;Development;Devices;Diagnosis;Disease;drug discovery;Ecosystem;effective therapy;Electrospray Ionization;Emerging Technologies;Equilibrium;Equipment;Equipment and supply inventories;evaporation;experimental study;Extramural Activities;falls;Glass;Goals;Government;Health;high throughput screening;improved;indigo dye;Informatics;informatics tool;Infrastructure;innovation;innovative technologies;instrument;instrumentation;Intellectual Property;Intelligence;Interdisciplinary Study;Intuition;ionization technique;knowledgebase;Laboratories;Laboratory Chemicals;Learning Module;Legal patent;Link;Liquid substance;Machine Learning;Manuals;manufacture;mass spectrometer;Mass Spectrum Analysis;Medicine;Methods;Microfluidics;Modeling;Modernization;National Center for Advancing Translational Sciences;next generation;novel;novel strategies;novel therapeutics;open source;operation;opioid use disorder;Organic Chemistry;Pain;Pathway Analysis;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;Phase;Positioning Attribute;Preparation;Process;Production;Professional Organizations;programs;prototype;Public Domains;Qualitative Methods;Reaction;Reagent;Reproducibility;Research;Research Personnel;Route;Running;Sampling;Schedule;Science;Scientist;screening;Secure;Services;sharing platform;simulation;Solid;Specific qualifier value;Spectrometry, Mass, Electrospray Ionization;Standardization;Structure;System;Systems Biology;technological innovation;Technology;Testing;Time;timeline;tool;Translational Research;Translations;United States National Institutes of Health;Universities;virtual;Vision;Work

PROJECT_TITLE: Development of A Specialized Platform for Innovative Research Exploration (ASPIRE)


ACTIVITY: ZIE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

PROJECT_TERMS: Acceleration;Award;Biomedical Engineering;biomedical imaging;Biomedical Technology;Clinical;clinical center;clinical translation;Collaborations;Development;Engineering;Fellowship;Fellowship Program;graduate student;Image;improved;Intramural Research;Joints;Mission;National Institute of Biomedical Imaging and Bioengineering;physical science;Postbaccalaureate;Postdoctoral Fellow;pre-doctoral;programs;Radiology Specialty;Research Personnel;Science;Scientist;summer internship;Talents;Technology;Training;Training Programs;Translational Research;undergraduate student;United Kingdom;United States National Institutes of Health;university student;Visit

PROJECT_TITLE: Intramural Training of NIH Biomedical Imaging and Bioengineering Researchers


PI_NAMEs: DMITROVSKY, ETHAN  (contact)

PROJECT_TERMS: Antineoplastic Agents;drug efficacy;drug testing;high throughput screening;Investigation;Modeling;Mutation;Organoids;Patients;Pharmaceutical Preparations;pre-clinical;predictive marker;Resistance;response biomarker;tumor;Tumor Tissue

PROJECT_TITLE: PREDICTIVE DRUG TESTING IN ORGANOID MODELS


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Arthritis;Clinical Research;Clinical Trials and Supportive Activities

ORG_NAME: KAI RESEARCH, INC

PI_NAMEs: YOU, HUIQING  (contact)

PROJECT_TERMS: Arthritis;Clinical Research;Clinical Trials;Contracts;Musculoskeletal Diseases;musculoskeletal injury;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;operation;research study;Rheumatism;Services;skin disorder;Source;Support Contracts

PROJECT_TITLE: CLINICAL STUDIES MANAGEMENT AND SUPPORT (CSMS) - SOLE SOURCE BRIDGE CONTRACT


FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

NIH_SPENDING_CATS: Breast Cancer;Cancer;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Lung;Lung Cancer;Ovarian Cancer;Pancreatic Cancer;Prevention;Prostate Cancer;Rare Diseases;Urologic Diseases;Women's Health Research

ORG_NAME: NATIONAL CANCER INSTITUTE

PROJECT_TERMS: Antibodies;Biological Assay;Biological Markers;cancer biomarkers;candidate marker;Colon Carcinoma;Coupled;Department of Energy;detection limit;Diagnosis;Diagnostic;Diagnostic Services;Early Detection Research Network;Laboratories;Liquid Chromatography;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Mass Spectrum Analysis;Measurement;Measures;Monitor;Pacific Northwest;Plasma;pressure;Prognosis;Reaction;Resolution;Resources;Screening for cancer;Serum;Specimen;tissue biomarkers;Tissues;Tumor Tissue;Urine;verification and validation;Work

PROJECT_TITLE: NCI Early Detection Research Network: Biomarker Reference and Resource Center (BRRC)


NIH_SPENDING_CATS: Neurosciences

ORG_NAME: THE EMMES COMPANY, LLC

PHR: Common data elements development, oversight of clinical trials, support for clinical research

PI_NAMEs: HEFNER, KATHRYN  (contact)

PROJECT_TERMS: archive data;Area;Clinical;clinical center;Clinical Data;Clinical Research;Clinical Trials;Common Data Element;Communities;Contractor;Contracts;data acquisition;data archive;design;Development;Education;Future;Methodology;Monitor;National Institute of Neurological Disorders and Stroke;Patients;Performance;Physicians;Policies;Preparation;programs;quality assurance;Quality Control;Resources;Services;Translations;United States National Institutes of Health;Work

PROJECT_TITLE: NINDS CENTER FOR CLINICAL TRIAL RESOURCES


ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PI_NAMEs: SEVERYNSE-STEVENS, DIANA  (contact)

PROJECT_TERMS: Acceleration;Award;Clinical Research;Contract Services;Development;Diagnosis;falls;first-in-human;Grant;Heart Diseases;Hematological Disease;Lung Diseases;Maintenance;National Heart, Lung, and Blood Institute;new technology;pre-clinical;preclinical development;preclinical study;Prevention;Process;programs;Reporting;Secure;Services;Sleep Disorders;Technology;technology development;translational pipeline;Work

PROJECT_TITLE: NHLBI CATALYZE PROGRAM - PRECLINICAL SERVICES COMPONENT - ADMINISTRATIVE SERVICES


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The areas of women’s health and sex differences research have long had an inadequate cadre of investigators with top quality training sufficient to make them competitive for limited research funding dollars. By using interdisciplinary training and excellent mentoring to develop the careers of the research leaders of tomorrow, we can address the most important, pressing questions in women's health and sex and gender differences. By equipping early career scientists to find the answers, we have every expectation that this grant will lead the way to tangible improvements in women's health in the United States.

PI_NAMEs: REGENSTEINER, JUDITH G. (contact);SANTORO, NANETTE F.

PROGRAM_OFFICER_NAME: TIGNO, XENIA

PROJECT_TERMS: Advisory Committees;Appointment;Bioinformatics;career;career development;Colorado;Complex;Educational Curriculum;Environment;evidence base;experience;Funding;Gender;Goals;Grant;Growth;health difference;improved;Individual;innovation;Institution;Interdisciplinary Study;K-Series Research Career Programs;Leadership;Learning;Medical;Medicine;Mentored Clinical Scientist Development Program;Mentors;Methods;programs;Publications;Publishing;Research;research and development;Research Design;research study;Scientist;sex;Sex Differences;skill acquisition;Talents;Time;tool;Training;Universities;Women's Health;Work

PROJECT_TITLE: The Colorado Building Interdisciplinary Research Careers in Women's Health Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(50)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative Intracellular bacterial pathogens remodel mammalian cell processes to replicate and cause disease. We propose to investigate how the intracellular pathogen Coxiella burnetii modulates the immune response to infection. This study will uncover fundamental details of the requirements for intracellular replication by bacterial pathogens and provide a possible therapeutic target for the treatment of these infections.

PI_NAMEs: DUNCAN-LOWEY, JEFFREY KARDAS (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Acute;Address;antimicrobial;Binding;Biochemical;Biological Assay;C-terminal;career;Caspase;Cell Physiology;Cells;Chronic;chronic infection;Clinical Skills;clinical training;Communicable Diseases;Coxiella;Coxiella burnetii;Cysteine;cytokine;Cytoplasm;Development;Disease;Double-Stranded RNA;Engineering;Environment;experience;experimental study;Gene Expression;Gene Family;Genetic Epistasis;Genome;Goals;Human;Immune response;Immunoprecipitation;immunoregulation;improved;In Vitro;Infection;insight;Interferon Type I;Learning;Link;Luciferases;Lysosomes;Macrophage;Mammalian Cell;Maps;microbial;Modeling;Molecular;Molecular Target;Mutagenesis;mutant;N-terminal;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Patient Care;Peptide Hydrolases;permissiveness;Physicians;Preparation;Process;Productivity;programs;Proteins;Reporter;Research Personnel;RNA;RNA Binding;Role;Scientist;sensor;Signal Induction;Signal Transduction;skills;Specialist;Substrate Specificity;System;Testing;therapeutic target;Training;transcriptome sequencing;Ubiquitin;ubiquitin isopeptidase;Vacuole

PROJECT_TITLE: The role of a Coxiella burnetii effector protein that inhibits RIG-I signaling


NIH_SPENDING_CATS: Cancer;Precision Medicine

PROJECT_TITLE: Assessment of the Precision Medicine Analysis and Coordination Center (PMACC)


NIH_SPENDING_CATS: Cancer;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Advisory Committees;cancer care;Collection;Consensus;Data;Data Collection;Data Element;data exchange;data interoperability;Data Set;data standards;Databases;Development;Diagnostic;effective therapy;Electronic Health Record;Elements;Fast Healthcare Interoperability Resources;Health system;innovation;Laboratories;Malignant Neoplasms;Medicaid;Medicare;Oncology;Prevention;programs;Public Health;Registries;Reproducibility;Research;Research Personnel;Source;Standardization;United States National Institutes of Health;Vendor;Work;working group

PROJECT_TITLE: NIH - ONC Cancer Domain Collab


PROJECT_TERMS: Academic Medical Centers;Budgets;Businesses;Cancer Center;Communication;Contractor;Contracts;cost effective;design;Development;Documentation;Federal Government;Future;Government;Guidelines;Health;information organization;Information Systems;Maintenance;Medical;Occupational activity of managing finances;operation;Paper;Patient Care;Policy Analysis;Procedures;programs;Recommendation;Regional Cancer;Reporting;Research;Resources;Service provision;Services;Support System;System;tool;Training;Training Support;Work

PROJECT_TITLE: Portfolio Management Systems Support Services (PM3S)


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Academic Medical Centers;biomedical informatics;Biomedical Research;Cancer Center;Capital;Communication;Contractor;Contracts;Environment;experience;Federal Government;Health;information organization;Information Systems;Information Technology;Investments;Joints;Knowledge;Life Cycle Stages;Medical;medical specialties;Office Management;operation;Patient Care;Performance;Process;programs;Regional Cancer;Research;Service provision;Services;System;United States Dept. of Health and Human Services;Work

PROJECT_TITLE: Program Management Office Support Services (PMOSS)


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Inflammatory bone diseases such as periodontitis and peri-implantitis are very significant health issues that severely affect patients' quality of life and increase the risk of other systemic diseases. It is critical to understand the mechanism underlying bone remodeling in periodontitis and peri-implantitis and to develop effective strategies that prevent inflammatory bone loss and repair bone damaged. This proposal will elucidate a novel mechanism by which F-BOX Protein11 (FBXO11) regulates bone development and inflammation, and render FBXO11 signaling as a new therapeutic target to control and regenerate bone loss in periodontitis and peri-implantitis.

PI_NAMEs: CHANG, JIA  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TITLE: Molecular control of bone development and inflammation by FBXO11

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Estrogen;Menopause;Physical Activity;Prevention;Sleep Research;Women's Health Research

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PI_NAMEs: WATTS, AMBER  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Big Data;bioinformatics tool;cardiometabolic risk;Chronic;Cognition;cognitive benefits;cognitive function;cognitive performance;cognitive testing;effective therapy;Electronic Health Record;exercise intervention;Future;Goals;Health;Impairment;improved;innovation;Intervention;Measurement;Measures;Mediating;Menopause;moderate-to-vigorous physical activity;Neurobehavioral Manifestations;Participant;Patient Self-Report;Performance at work;Perimenopause;Physical activity;Physiological;Postmenopause;protective factors;Psychological Factors;psychological symptom;recruit;Reporting;Research;Risk;Risk Factors;Sampling;Sleep;Sleep disturbances;Societies;Symptoms;United States National Institutes of Health;vasomotor symptoms;Woman;Women's Health

PROJECT_TITLE: Protective and Risk Factors for Cognitive Function in the Menopause Transition

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-9 (C1)]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: FAIRFAX

ORG_NAME: BLACK CANYON CONSULTING LLC

PI_NAMEs: ESSER, HALEY  (contact)

PROJECT_TERMS: Alleles;Bacterial Drug Resistance;Bacterial Genome;Basic Science;beta-Lactamase;bioinformatics tool;colistin resistance;Collection;Combating Antibiotic Resistant Bacteria;Databases;Genes;Nomenclature;Organism;quinolone resistance;Research;Resistance;Resources;Services;tool;United States National Institutes of Health

PROJECT_TITLE: Bioinformatics Tools and Services at NCBI for Combating Antibiotic Resistant Bacteria Research


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Microbiome;Neurosciences;Pain Research;Prevention;Rural Health;Social Determinants of Health

ORG_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

PI_NAMEs: SALIGAN, LEOREY  (contact)

PROJECT_TERMS: Age;Anesthetics;Anxiety;Area;associated symptom;Autoimmune Diseases;behavioral health;bench to bedside;Bioenergetics;Biological;biopsychosocial factor;Brain-Derived Neurotrophic Factor;built environment;cancer biomarkers;Cancer Center;Cancer Patient;Cancer Survivor;cancer therapy;cancer-related cognitive impairment;Chronic;Chronic Disease;Chronic Fatigue Syndrome;climate change;Clinical;Clinical Research;Clinical Trials;Code;Collaborations;Colorectal Cancer;Communities;Complex;Dedications;Discrimination;Dose;Enrollment;Ensure;Environmental Risk Factor;Ethnic Origin;experience;Extramural Activities;farmer;Fatigue;Female;Female Breast Carcinoma;fibromyalgia patients;Financial Hardship;frailty;functional improvement;Functional Magnetic Resonance Imaging;functional outcomes;Genetic Polymorphism;Goals;gut microbiota;Health;health care settings;Health Promotion;Housing;Immigrant;improved;indexing;Individual;innovation;Intervention;Intravenous;Investigation;Ketamine;Knowledge;Laboratories;Link;Location;Long COVID;Magnetic Resonance Spectroscopy;male health;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mental Depression;microbiota;Mission;Mitochondria;mortality;Muscle Mitochondria;National Cancer Institute;National Center for Complementary and Integrative Health;National Institute on Aging;neural circuit;Neurocognitive Deficit;novel therapeutics;Outcome;Outcome Study;Pain;painful neuropathy;Paper;Participant;Patient Self-Report;Patients;Perception;Performance;Persons;Phosphorus;physical conditioning;Physical environment;physical impairment;Population;Prevention;programs;Psychosocial Factor;Publications;Publishing;Quality of life;Race;Reporting;Research;Research Activity;Resources;Risk Factors;Rural;rurality;Scientist;Self Management;sex variable;Sexual Health;Skeletal Muscle;Sleep disturbances;social;Social Environment;social factors;Socioeconomic Status;symptom cluster;Symptoms;theories;Therapeutic;Translations;United States;United States National Institutes of Health;Urban Community;walkability;Work

PROJECT_TITLE: Investigating Correlates and Therapeutics of Fatigue


NIH_SPENDING_CATS: Genetics;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PI_NAMEs: LAWAL, TOKUNBOR  (contact)

PROJECT_TERMS: Affect;Animal Model;Antioxidants;Biopsy;Birth;Calcium;Cell model;Cells;Coenzyme A;congenital myopathy;Contracts;Coupling;Disease;disease model;disease-causing mutation;experimental study;Functional disorder;Gatekeeping;Genes;genetic variant;Goals;improved;In Vitro;in vivo;Individual;Measures;Mesylates;mouse model;Muscle;Muscle Cells;Muscle Fibers;Muscle function;Muscle Weakness;Mutation;N-3 polyunsaturated fatty acid;Nicotinamide adenine dinucleotide;Oxidative Stress;Pathogenicity;Patients;pediatric patients;phase 1 study;Predisposition;Process;protein function;Proteins;release of sequestered calcium ion into cytoplasm;RyR1;safety testing;Sampling;Sarcoplasmic Reticulum;Skeletal Muscle;Skin;stem cells;Structure;Testing;Therapeutic;Tissue Banks;Variant;variant of unknown significance;Zebrafish

PROJECT_TITLE: Functional characterization of genetic variants of uncertain significance in genes associated with excitation-contraction coupling disorders


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PI_NAMEs: HALL, MATTHEW  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;atypical pneumonia;betacoronavirus;Biological Assay;biomedical scientist;Biotechnology;Clinical;Clinical Data;Communities;COVID-19;COVID-19 pandemic;COVID-19 pneumonia;COVID-19 therapeutics;dashboard;Data;data portal;Data Reporting;Data Set;data sharing;Disease;drug mechanism;drug repurposing;Economics;Goals;Government;high throughput screening;In Vitro;insight;Laboratories;lead candidate;Metadata;Names;National Center for Advancing Translational Sciences;novel;open data;pandemic disease;pandemic response;Pharmaceutical Preparations;Pharmacologic Substance;predictive modeling;Process;Protocols documentation;public database;Public Health;Publications;Publishing;Reporting;Research;Research Personnel;Resources;response;SARS-CoV-2 variant;screening;Site;Societies;Testing;Therapeutic;Therapeutic Intervention;therapy development;Time;tool;Update;user-friendly;Vaccines;Variant;Viral

PROJECT_TITLE: An OpenData Portal to share SARS-CoV-2 drug repurposing data in real time


PROJECT_TERMS: 2019-nCoV;3-Dimensional;Acceleration;Address;Adopted;Alpha Virus;Anti-viral Agents;anti-viral efficacy;antiviral drug development;Arenavirus;assay development;BCAR3 gene;Binding;Biochemical;Biological Assay;Biology;Bunyavirales;Cells;Cerebral endothelium;Chemicals;Chemistry;Chikungunya virus;clinical development;Clinical Trials;Collaborations;Collection;combat;Complex;Containment;Coronavirus;COVID-19 therapeutics;COVID-19 treatment;Data;Dedications;Dengue Virus;design;Development;Disease;disease model;DNA;DNA biosynthesis;drug development;drug discovery;Drug Evaluation;Drug Kinetics;drug metabolism;Eastern Equine Encephalitis Virus;Ebola;efficacy validation;emerging virus;endonuclease;Energy Transfer;Enterovirus 68;Evaluation;Exonuclease;Exposure to;Extramural Activities;Family;Family Picornaviridae;Flaviviridae;Flavivirus;Fostering;future pandemic;Goals;high throughput screening;high-throughput drug screening;Hospitalization;Human;human coronavirus;in silico;in vitro Assay;in vitro Model;in vivo;Infection;inhibitor;interest;Investigational Drugs;Investigational New Drug Application;Kunjin virus;Lassa virus;Lead;lead optimization;Length;Libraries;Liquid substance;Literature;Liver;Luciferases;Lung;Mayaro virus;member;Metals;Methyltransferase;Modeling;mutant;Mutation;nanoluciferase;National Center for Advancing Translational Sciences;neural;neurotropic virus;novel;novel therapeutics;Oral;outbreak concern;pandemic disease;pandemic potential;Papain;Paramyxovirus;Paxlovid;Peptide Hydrolases;Pharmaceutical Chemistry;pharmacophore;Physiological;Play;Pneumovirus;pre-clinical;preclinical development;Preparation;prevent;programs;Property;rapid testing;Reader;Recombinants;Reporter;Research Personnel;RNA-Directed RNA Polymerase;Role;Safety;SARS-CoV-2 inhibitor;SARS-CoV-2 protease;SARS-CoV-2 variant;screening;Serotyping;Severe Acute Respiratory Syndrome;Small Intestines;small molecule;small molecule libraries;spheroids;Structure-Activity Relationship;synergism;System;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissue Model;Togaviridae;Toxicology;United States Food and Drug Administration;United States National Institutes of Health;Validation;variants of concern;vascular bed;Venezuelan Equine Encephalitis Virus;Venezuelan Equine Encephalomyelitis;Viral;Viral Load result;viral outbreak;viral pandemic;Viral Physiology;Viral Proteins;virology;Virus;Virus Diseases;Virus Inhibitors;virus testing;West Nile virus;Work;working group;Zika Virus

PROJECT_TITLE: Antiviral Program for Pandemics (APP) & NCATS: Accelerating Antiviral Development


ACTIVITY: ZIH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Eye Disease and Disorders of Vision;Infectious Diseases;Machine Learning and Artificial Intelligence;Malaria;Networking and Information Technology R&D (NITRD);Rare Diseases;Vector-Borne Diseases

ORG_NAME: NATIONAL LIBRARY OF MEDICINE

PI_NAMEs: MORK, JAMES  (contact)

PROJECT_TERMS: Address;Africa;American;Area;base;biobank;Biological Models;biomedical informatics;Blood;career;Cataloging;Classification;Clinical;clinical center;Clinical Data;clinical imaging;Clinical Informatics;Clinical Research;Clinical Sciences;clinical trial protocol;Clinical Trials;Code;Collaborations;Color;Complex;computerized data processing;Data;data communication;Data Science;Data Set;data standards;deep learning;deep learning algorithm;design;Detection;Development;Electronic Health Record;Electronic Mail;Eligibility Determination;Environment;Extravasation;Fast Healthcare Interoperability Resources;Fluorescein Angiography;Fundus;fundus imaging;Goals;Guidelines;Health;Healthcare;HIV;HIV/AIDS;Hour;Human;Hygiene;Image;image processing;Immunology;improved;indexing;Individual;Informatics;innovation;Institution;Intellectual Property;interest;Internet;Investigation;Journals;large language model;Lead;Leadership;Legal patent;Machine Learning;Malaria;Measures;MEDLINE;meetings;MeSH Thesaurus;Microbiology;mobile application;Modeling;Molecular;Monitor;Needs Assessment;Optic Disk;optical disc;Outcome;Paper;parallel processing;Parasitemia;Parasites;Patients;Performance;Policies;Process;programs;prototype;Public Health Schools;Publications;Reporting;Research;Research Institute;Research Personnel;Resources;Retina;Retinal Vasculitis;Rodent;Rodent Model;sensor;smartphone application;SNOMED Clinical Terms;software development;special interest group;System;Systematized Nomenclature of Medicine;Terminology;Thoracic Radiography;Time;tool;tool development;Trademark;Training;Translating;Translational Research;Treaty;Tropical Medicine;United States;United States National Institutes of Health;United States National Library of Medicine;Update;Uveitis;Vision;web site;Work

PROJECT_TITLE: Applied Clinical Informatics


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Burden of Illness;Complementary and Integrative Health

PROJECT_TERMS: Adult;Caring;Centers for Disease Control and Prevention (U.S.);Child;Complementary Health;cost;Disease;Frequencies;Individual;Integrative Medicine;National Health Interview Survey;Prevalence;Questionnaires;Sampling

PROJECT_TITLE: National Health Interview Survey by Centers for Disease Control and Prevention


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: MANGALAMPALLI, VENKATA  (contact)

PROJECT_TERMS: adeno-associated viral vector;analytical method;Bioreactors;cell bank;Chemistry;Clinical;Clinical Research;Cyclic GMP;Development;Equipment and supply inventories;gene therapy;Generations;Genes;interest;Investigational New Drug Application;manufacture;manufacturing process;National Center for Advancing Translational Sciences;open source;Pharmaceutical Preparations;Preparation;Process;Serotyping;Shipping;Testing

PROJECT_TITLE: NCATS-DPI-22-0101 - CREATION OF AN OPEN-SOURCE PROCESS TO MANUFACTURE AAV VECTOR-BASED GENE THERAPY CANDIDATES FOR NON-COMMERCIAL CLINICAL STUDIES