NIH_SPENDING_CATS: Clinical Research;Lung;Machine Learning and Artificial Intelligence;Organ Transplantation;Prevention;Transplantation

ORG_STATE: NC

PHR: PROJECT NARRATIVE Lung transplant is the only option for treatment of end-stage lung disease, but requires remarkable resources and carries a considerable risk of early post-operative complications. Within our four-transplant center collaboration, we propose a detailed analysis of pretransplant clinical variables and objective measurements of biological aging through mechanistic assays processed with machine learning in order to quantify the risk of perioperative complications and identify modifiable risk factors. Additionally, our centers will help develop and contribute approximately 200+ patients annually (75%+ of annual adult lung transplant volume) to the larger proposed lung transplant consortium.

PI_NAMEs: HARTWIG, MATTHEW GALEN;SNYDER, LAURIE D (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Abdomen;Acute;Address;Adopted;Adult;Aging;Biological;biological age;Biological Aging;Biological Assay;Biological Factors;Body System;Cells;Characteristics;Clinical;clinical center;Collaborations;Complication;cost;Country;cytokine;Data;Data Coordinating Center;Discipline;Economic Burden;Enrollment;Failure;Freedom;Functional disorder;Funding Opportunities;Future;Geography;Goals;graft dysfunction;graft failure;Graft Survival;Health system;Hospital Costs;Immune;Immunity;improved;improved outcome;Individual;Infection;Intervention;Kidney Failure;Lung;lung allograft;Lung Diseases;Lung Transplantation;Machine Learning;machine learning prediction;Measurement;Measures;Minnesota;Modeling;modifiable risk;novel;Operative Surgical Procedures;Organ;Orthopedic Surgery;Outcome;outcome prediction;Output;participant enrollment;Patient-Focused Outcomes;Patients;Pennsylvania;Peptides;Performance;Perioperative;Perioperative complication;Physiological;Positioning Attribute;Postoperative Complications;Postoperative Period;Predictive Factor;predictive modeling;predictive tools;Procedures;Process;Prospective cohort;Protocols documentation;Provider;Publications;Publishing;recruit;Registries;Research;Research Project Grants;Resources;response;Risk;Risk Assessment;Risk Factors;risk prediction model;senolytics;Site;surgery outcome;Surrogate Endpoint;Textbooks;Time;transplant centers;Transplant Recipients;Transplantation;Transplantation and Immune System;Universities;Viral

PROJECT_TITLE: Clinical and Biological Factors Predicting Lung Transplant Textbook Outcomes (U01)


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Sleep Research;Substance Misuse

ORG_CITY: IOWA CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The goal of these studies is to determine whether alcohol enhances the progression of tau pathology in the brain by altering neuronal activity in serotonin neurons in the dorsal raphe. The resulting disruption of sleep homeostasis and neuroinflammation in the dorsal raphe may enhance propagation of tau pathology both locally and in distal regions of the brain, eventually resulting in cognitive decline. Ultimately, this investigate will establish the dorsal raphe serotonin system as an important neural substrate in the early stages of Alzheimer's disease that is impacted by alcohol use, which could play a significant role in the progression of tau pathology and the onset of cognitive and memory deficits.

PI_NAMEs: MARCINKIEWCZ, CATHERINE ANNE (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: 3-Dimensional;Acceleration;Adoptive Transfer;Age of Onset;Aging;Alcohol consumption;alcohol effect;alcohol exposure;alcohol use disorder;Alcohols;Alzheimer's Disease;Alzheimer's disease related dementia;Anxiety;Area;Attention;Behavior;Brain;Brain region;Chronic;chronic alcohol ingestion;Chronic Insomnia;Clinical;Cognitive deficits;Data;Dementia;depressive symptoms;designer receptors exclusively activated by designer drugs;Development;Distal;Dorsal;dorsal raphe nucleus;Early Intervention;Electroencephalography;Electrophysiology (science);entorhinal cortex;Exhibits;Exposure to;Fiber;Genes;Genetic;glial activation;Goals;Hippocampus;Homeostasis;hTau Mice;Human;Image;Impaired cognition;in vivo;insight;Investigation;late life;Light;Link;Literature;Memory impairment;Microglia;Mus;Nerve Degeneration;neural;neurofibrillary tangle formation;Neurofibrillary Tangles;neuroinflammation;neuromechanism;Neurons;neuropathology;new therapeutic target;non rapid eye movement;Pathogenesis;Pathology;Photometry;Play;Process;Property;Protein Isoforms;Recording of previous events;Research;restoration;Role;Serotonergic System;Serotonin;Sleep;Sleep Deprivation;Sleep disturbances;sleep pattern;Sleeplessness;Synapses;synergism;tau aggregation;tau Proteins;Techniques;Viral Vector;Work

PROJECT_TITLE: Alcohol and the Serotonin System in the Progression of Alzheimer's Disease


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: PITTSBURGH

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative This study is relevant to the public health because large population (half of adult population) is affected by periodontitis, and the methods used in this study can be easily translated to noninvasive clinical treatment. In addition, this study will establish the efficacy of recruiting and differentiating macrophages to M2 macrophages which could also be used as a treatment to other chronic inflammatory diseases.

PI_NAMEs: SFEIR, CHARLES  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Ablation;Acceleration;Address;Adoptive Transfer;Adult;Affect;aged;Alveolar Bone Loss;Anti-Inflammatory Agents;Antibiotics;Bacterial Infections;bone loss;Calculi;Cardiovascular Diseases;Cell Separation;Cells;chemokine;chronic inflammatory disease;Clinical;Clinical Treatment;Communities;cytokine;Data;Debridement;dental biofilm;Dental Calculus;Dental Plaque;Diabetes Mellitus;Disease;Disease Progression;dysbiosis;Etiology;experimental study;feasibility testing;Genetic;Gingiva;Harvest;Helper-Inducer T-Lymphocyte;Homeostasis;Homing;Immune;Immune response;Immune system;immunoregulation;in vivo;Inflammation;Inflammatory;inflammatory bone loss;Inflammatory Response;insight;Interleukin-10;Interleukin-4;Intervention;Knockout Mice;Ligands;Ligature;Light;Macrophage;Maxilla;Methods;Microbe;microbial;Microbial Biofilms;microbiota;microCT;Modality;Modeling;monocyte;Mouth Diseases;Mus;Nature;novel;novel therapeutic intervention;Nutrient;particle;particle therapy;pathogen;Pathogenesis;Patients;Periodicals;Periodontal Diseases;Periodontitis;Periodontium;Phase;Phenotype;Play;Population;Premature Birth;prevent;Preventive therapy;Process;Public Health;Rattus;recruit;repaired;Reporting;Research;Resolution;response;Role;Severities;single-cell RNA sequencing;Stains;standard care;standard of care;System;Systemic disease;Technology;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;Tissue Harvesting;Tissues;Tooth Loss;Tooth structure;Translating;tumor-immune system interactions;United States;Wild Type Mouse

PROJECT_TITLE: Treatment of Periodontitis by Homing M2 Macrophages

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: NARRATIVE This study uses a comprehensive approach to uncover how multi-functional protein BrpA modulates the biofilm matrix and affects Streptococcus mutans biofilm formation, and employs a structure and function relationship guided strategy to optimize the lead small inhibitory molecules that can effectively and selectively modulate S. mutans biofilm formation. Information derived from this study will also facilitate the development of novel therapeutic and preventative strategies to combat human dental caries.

PI_NAMEs: WEN, ZEZHANG TOM (contact);WU, HUI

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Affect;Anabolism;anticaries;Bacteria;Binding;Biochemical;Biogenesis;Bioinformatics;Biological Assay;Biophysics;cariogenic bacteria;cell envelope;Cell Physiology;Cell Wall;combat;Communicable Diseases;cost;Cost of Illness;Culture Media;dental biofilm;Dental caries;Dental Plaque;Development;DNA Footprint;Dose;EMSA;Enzymes;Epitopes;Foundations;Functional disorder;Genetic;genetic regulatory protein;Genetic Transcription;Glucans;Glucosyltransferases;Goals;Gram-Positive Bacteria;Growth;Health Care Costs;Human;in silico;In Vitro;in vivo;insight;Lead;lead optimization;Lesion;Ligands;Ligase;Luciferases;Mediating;Microbial Biofilms;Modeling;Modernization;Molecular;Mouth Diseases;Mutagenesis;mutant;Northern Blotting;novel;novel strategies;novel therapeutics;Odontogenesis;oral microbial community;Organic Chemistry;Outcome Study;Pathogenesis;Pharmaceutical Preparations;Play;Polymers;posttranscriptional;premature;Prevention;Prevention strategy;Production;protein complex;Protein Family;Proteins;Rattus;Recombinants;Regulation;Reporter;RNA;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;screening;Seminal;small molecule;small molecule libraries;Solid;Streptococcus;Streptococcus mutans;structural biology;Structure;Surface;Techniques;Testing;tool;tooth surface;Transcript;transcription factor;transcription termination;Virulence;X-Ray Crystallography

PROJECT_TITLE: BrpA in Virulence Modulation of Streptococcus mutans


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Smoking rates among persons living with HIV (PLH) in the US are triple those in the general adult population, and PLH are much less likely to quit smoking—possibly due to the HIV-specific stressors they face. To address the need for program that address their particular needs, this study will compare two group-based video-conferencing PLH programs in terms of their effects on smoking cessation and how cessation affects HIV-related health outcomes. As the first study of its kind, the proposed research will yield important insights into a program that could be made widely available to reach PLH smokers throughout the US.

PI_NAMEs: MARHEFKA, STEPHANIE LYNN (contact)

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: Abstinence;Accounting;Address;Adult;Affect;Area;Attention;Biochemical;cancer survival;Caring;CD4 Lymphocyte Count;Cessation Research;Chronic Obstructive Pulmonary Disease;comorbidity;Control Groups;cost;cost effectiveness;Counseling;Data;design;economic evaluation;effectiveness measure;efficacy evaluation;eHealth;Elements;Enrollment;Ensure;Epidemic;Evidence based program;Face;fighting;Florida;follow-up;Future;General Population;Geography;Health;Health Benefit;health disparity;Heart Diseases;HIV;HIV/AIDS;improved;Individual;innovation;insight;Internet;Intervention;intervention effect;Knowledge;knowledge base;Life;Life Expectancy;Light;Literature;Loneliness;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;Mediator;Mental Depression;Meta-Analysis;Methodology;Modeling;mortality;Motivation;Nicotine Dependence;nicotine replacement;novel;Online Systems;Outcome;Participant;Persons;pilot trial;Population;Positioning Attribute;post intervention;Prevalence;Prevention;primary outcome;program costs;programs;prolonged abstinence;prospective;Pulmonary Emphysema;Randomized;Randomized, Controlled Trials;recruit;Research;Research Personnel;response;Role;Science;Self Efficacy;Services;skills;Smoke;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;social cognitive theory;standard care;stressor;Stroke;Technology;therapy design;Tobacco;Tobacco use;Tobacco Use Cessation;Training;Travel;treatment effect;Treatment Efficacy;Treatment outcome;treatment program;treatment strategy;Underserved Population;United States National Institutes of Health;Videoconferencing;Viral Load result;Voice

PROJECT_TITLE: The Positively Quit Trial: Addressing disproportionate smoking rates among people living with HIV

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: LOUISVILLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: This project investigates the perception of speech in the context of surrounding sounds for the normal auditory system, and the effects of background noise, hearing loss, and cochlear implant processing on speech perception. These context effects play a critically important in perception, allowing us to maintain stable perception despite considerable variability in sounds and in listening environments. An improved understanding of context effects should lead to improvements in hearing aids and cochlear implants, which will help individuals with hearing difficulties communicate more effectively.

PI_NAMEs: STILP, CHRISTIAN EDMUND (contact);WINN, MATTHEW BRANDON

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acoustics;Address;Affect;Auditory;auditory pathway;Auditory Perception;auditory processing;Auditory system;Behavioral;Bypass;Cochlear Implants;Code;Communication;Communication difficulty;Computer Models;contrast enhanced;Cues;Environment;Event;Experimental Models;experimental study;Foundations;Frequencies;Goals;Grain;Hearing Aids;hearing impairment;Hearing problem;Impairment;improved;Individual;Individual Differences;insight;Intervention;Investigation;Knowledge;Link;Measures;Methods;model design;Modeling;Nerve;neural;neural model;neuroadaptation;neuromechanism;Noise;normal hearing;Pattern;Perception;Peripheral;Play;Population;Process;Property;Psychoacoustics;Reporting;response;Role;Sensorineural Hearing Loss;sensory system;Shapes;sound;spectral energy;Speech;Speech Acoustics;Speech Perception;Speech Sound;Stimulus;Stream;System;Testing;Time;translational applications;translational framework;Work

PROJECT_TITLE: Perception of speech in context by listeners with healthy and impaired hearing

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Contraception/Reproduction;Emerging Infectious Diseases;Infectious Diseases;Infertility;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ITHACA

ORG_DEPT: ZOOLOGY

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: To reduce or eliminate transmission of serious viruses causing dengue, Zika, and chikungunya, methods are needed to control the reproductive capacity and survival of the mosquitoes that transmit them. Molecules in seminal fluid that modulate mosquito re-mating behavior and harmonic convergence, egg production, survival, and promote sperm storage and viability are excellent species-specific targets for such vector control. Having narrowed down candidate active seminal fluid proteins from hundreds to a small list, and identified small- molecules in ejaculate, we will now focus on their functional analysis. We will also determine and analyze male- and female-derived molecules that complex with sperm to influence sperm viability and longevity during storage.

PI_NAMEs: HARRINGTON, LAURA C (contact);WOLFNER, MARIANA FEDERICA

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Aedes;Affect;Ammonium;Anopheles Genus;Arbovirus Infections;Attention;Behavior;Behavioral;Biological Assay;Biology;Blood;Cell Physiology;Ceramics;Charge;chikungunya;Chikungunya virus;Chromatography;Complex;CRISPR/Cas technology;Culicidae;Data;Dengue;Dengue Virus;design;Development;Disease Vectors;Drosophila genus;Ecdysone;Ecdysteroids;egg;Ejaculation;Event;experience;feeding;Female;female reproductive tract;Fertility;fitness;Fractionation;Funding;Gene Expression;Gene Proteins;Genes;Gland;Goals;Grant;Homologous Gene;Hormones;Human;Hydrophobicity;Hydroxyapatites;Individual;Infection;inhibitor;Insecta;Insecticides;insight;Interruption;Juvenile Hormones;knock-down;Life;life history;Longevity;Maintenance;male;male fertility;Mass Spectrum Analysis;mating behavior;Mediating;Men's Role;metabolomics;Methods;Molecular;Mosquito Control;Mosquito-borne infectious disease;Movement;mutant;novel;Oviposition;Partner in relationship;peptide analog;Peptides;Physiological;Play;Population;Production;Proteins;Proteolysis;Refractory;Reproduction;reproductive;Reproductive Biology;reproductive fitness;reproductive success;Research;response;Rest;RNA Interference;Role;screening;Secretory Cell;Seminal;Seminal fluid;Serine Protease;single nucleus RNA-sequencing;small molecule;Solid;Source;sperm cell;sperm function;sperm protein;sperm viability;success;Testing;Time;tool;transmission process;vector;vector control;vector mosquito;Virus;Work;Yellow Fever;ZIKA

PROJECT_TITLE: New Targets for Reproductive Control of Mosquito Vectors

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: College Station

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: Narrative The Office of the Texas State Chemist (OTSC) Laboratory Flexible Funding Model (LFFM) involves strengthening the capacity and capabilities of the OTSC laboratory in support of an integrated food safety system in the disciplines of microbiology, chemistry and radiochemistry in food defense, animal food product testing, whole genome sequencing, capability/capacity development, and special project tracks. There are nine projects in total and will utilize newly developed OTSC infrastructure including two biosecurity level 3 laboratories, newly acquired instrumentation for radiochemistry surveillance and instrument updates involving high performance liquid chromatography, ultrahigh performance liquid chromatography, and inductively couple plasma – with mass spectrometry detection. As an outcome of this program, OTSC will be better equipped to support the national integrated food safety system and improve the overall safety of animal and human food in Texas, the United States and abroad.

PI_NAMEs: HERRMAN, TIMOTHY JOHN (contact)

PROGRAM_OFFICER_NAME: CHRYSOGELOS, CHRISTINA

PROJECT_TITLE: Texas Food Defense and Animal Food Product Testing for Microbiological, Chemical and Radiological Hazards, Genome Sequencing, and Special Project Tracks


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Microbiome;Precision Medicine

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Diarrhea-predominant irritable bowel syndrome (IBS-D) is a chronic disease of the gastrointestinal tract, which affects about 2.1-4.5% of the United States population. A diet high in fermentable oligo-, di- and mono- saccharides exacerbates IBS-D symptoms while a diet low in FODMAPs provides some symptomatic relief in ~50-60% of these patients. The proposed research will advance our understanding of the role of FODMAPs in the pathophysiology of IBS allowing for more effective, individualized treatment for patients with IBS-D, which in turn will improve patient satisfaction with treatment and reduce healthcare costs.

PI_NAMEs: SINGH, PRASHANT  (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Affect;antagonist;Cell Culture Techniques;Chronic diarrhea;Chronic Disease;Client satisfaction;Clinical;Clinical Research;clinical translation;Colon;Data;Diarrhea;Diet;Dietary Intervention;Digestive System Disorders;Disaccharides;dysbiosis;Enterobacteriaceae;Epithelium;Family;fructooligosaccharide;Fructose;Functional disorder;Funding;Goals;Gram-Negative Bacteria;Growth;Health Care Costs;Human;human disease;improved;In Vitro;in vitro Model;in vivo;individualized medicine;ineffective therapies;International;Intervention;Irritable Bowel Syndrome;Knowledge;Lipopolysaccharides;mast cell;Mediating;Mentors;Mentorship;microbial;microbiome;microbiome alteration;microbiome analysis;Modeling;Molecular;Monosaccharides;Mucous Membrane;Mus;Myosin Light Chain Kinase;novel strategies;Oligonucleotides;Oligosaccharides;Outcome;PAR-2 Receptor;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Play;polyol;Population;Precision Health;precision medicine;Precision therapeutics;Prevalence;Productivity;recruit;Regulation;Research;Research Personnel;responders and non-responders;Rodent;Rodent Model;Role;Severities;Signal Transduction;skills;Source;Structure;Subgroup;Symptoms;targeted treatment;Testing;TLR4 gene;Training;Translating;translational approach;translational scientist;Tryptase;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Role of FODMAPs in the pathophysiology of diarrhea-predominant Irritable bowel syndrome

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE DEPT OF AGRIC/CONSUM SRVCS

PHR: Project Narrative The Florida Department of Agriculture and Consumer Services (FDACS), Division of Fruit and Vegetables (DFV), is requesting funding that would allow the DFV to continue to develop a produce safety program that provides education, outreach and technical assistance to Florida’s Agriculture Industry to help prevent food borne illness outbreaks and promote good agricultural practices. Through our outreach efforts, the long-term benefit to Florida’s Agriculture Industry is enhanced marketability and increased consumer confidence in locally grown fruit and vegetables.

PI_NAMEs: MCCLURE, MANLEY SCOTT (contact)

PROGRAM_OFFICER_NAME: VARGO, ADRIANNA

PROJECT_TITLE: Path B Florida Produce Safety Cooperative Agreement Program for 2021-2026


ORG_CITY: BOISE

ORG_NAME: IDAHO STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: ID

PHR: Project Narrative Project Title: Idaho PATH C – Implementation of a Produce Safety Program This proposal to Path C identifies the Idaho State Department of Agriculture’s (ISDA) strategy for planning and establishment of Idaho’s Produce Safety Program to encourage the safe production of fresh fruits and vegetables and increase knowledge of and compliance with the U.S. Food and Drug Administration’s (FDA) Produce Safety Rule (PSR) (21 CFR Part 112). This program will focus on strategies and plans to apply national consistency and meet the highest possible quality expectations while advancing efforts towards a national integrated food safety system. This project will evaluate Idaho’s unique produce safety landscape, prioritize commodities and farms regulated by the rule, and develop programs to address Idaho’s specific and unique needs for regulatory compliance and training.

PI_NAMEs: MONN, CASEY  (contact)

PROGRAM_OFFICER_NAME: HOEHNA, SHANNON

PROJECT_TITLE: Path C Idaho  Implementation of a Produce Safety Program


ORG_CITY: AUGUSTA

ORG_NAME: MAINE STATE DEPARTMENT OF AGRICULTURE, CONSERVATION AND FORESTRY

ORG_STATE: ME

PHR: Project Narrative The Continued Implementation of a Produce Safety Program by the Maine Department of Agriculture, Conservation and Forestry under Path B is a 5-yr project that will enhance produce safety by providing education and outreach to produce farms and implementing a consistent regulatory compliance inspection program for the Produce Safety Rule in the State of Maine. This project will fund efforts to reach all of Maine's produce farms to improve produce safety knowledge and practices in the state, and to develop produce safety practices specific to Maine's unique commodity groups. This work will be undertaken in cooperation with our FDA partners and other agricultural service providers in our state and region.

PI_NAMEs: POULIN, CELESTE J. (contact)

PROGRAM_OFFICER_NAME: FREDRICK, JEANETTE

PROJECT_TITLE: Path B The FDA's Cooperative Agreement Program for States and Territories to Implement a National Produce Safety Program under PAR-21-174


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: LITTLE ROCK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: NARRATIVE – OVERALL The Center for Research, Health, and Social Justice (CRHS) will use a social justice framework to conduct research, engage communities, and build a diverse and competent research workforce to reduce disparities in cancer and cardiovascular disease. Social justice focuses on improving lives and wellbeing of historically marginalized and oppressed groups that face racism and discrimination. The CRHS is designed to become a national model for eliminating chronic disease disparities using social justice informed research, training, and community engagement.

PI_NAMEs: CORNELL, CAROL ELLEN (contact);FAGAN, PEBBLES ;GUY, MIGNONNE CATHERINE

PROGRAM_OFFICER_NAME: JOSEPH, SUSAN KALAPURA

PROJECT_TERMS: Address;African American;African American population;Arkansas;Black Populations;Black race;cancer health disparity;Cardiovascular Diseases;Chronic Disease;Clinical and Translational Science Awards;Collaborations;Communities;community academic partnership;community engagement;community intervention;community partners;community partnership;County;Death Rate;design;Development;Disadvantaged;Discrimination;disease disparity;disorder risk;Disparity;disparity elimination;disparity reduction;Distress;economic indicator;Ecosystem;Employment Opportunities;Equity;Ethnic Population;evidence base;experience;Extramural Activities;Face;food insecurity;Foundations;Funding;Generations;Goals;Grant;Health;health care availability;Health Disparities Research;health disparity;health inequalities;Heart Diseases;improved;Infrastructure;innovation;Institution;interdisciplinary collaboration;Intervention;Knowledge;Left;lens;Life Cycle Stages;Life Expectancy;Link;Malignant Neoplasms;marginalization;Measures;member;Mentors;Methods;Modeling;Monitor;mortality;National Institute on Minority Health and Health Disparities;novel;Outcome;Pattern;Personal Satisfaction;Pilot Projects;Policies;Postdoctoral Fellow;Poverty;Process;programs;Race;racial disparity;racial population;racism;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk Factors;Rural;rural area;rural dwellers;Science;skills;Social Justice;social structure;socioeconomics;Standardization;structural determinants;Structure;success;Surveys;System;tool;Training;Training and Infrastructure;training opportunity;Translating;Translational Research;Trauma;Trust;Underrepresented Populations;United States;United States National Institutes of Health;urban area;Wages;Work


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: CORNELL, CAROL ELLEN (contact)

PROJECT_TERMS: Academy;Achievement;Address;Adopted;Arkansas;Award;cardiovascular disorder risk;career;career development;Chronic Disease;Common Data Element;Communication;Communities;community academic partnership;Community Health Aides;community partnership;Competence;Data;data sharing;Decision Making;Development;Development Plans;Discrimination;disease disparity;Ecosystem;Ensure;Equity;Evaluation;Fostering;Foundations;Geographic Information Systems;Goals;Grant;Health;Health Disparities Research;health disparity;Health Promotion;Human Rights;Individual;innovation;Institution;Intervention;Leadership;lens;Malignant Neoplasms;Maps;Measures;Medical;meetings;member;Methodology;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;National Institute on Minority Health and Health Disparities;novel;operation;Organizational Efficiency;Outcome;Play;Policies;Postdoctoral Fellow;Procedures;Process;Progress Reports;Recommendation;Regulation;Research;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Resources;Risk Factors;Role;Safety;Science;social;Social Justice;social structure;structural determinants;Structural Racism;Structure;success;training opportunity;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Virginia

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WILLIAMS, MARK L (contact)

PROJECT_TERMS: Acceleration;Address;Affect;African American population;Applications Grants;Arkansas;Award;Black race;burden of chronic illness;cancer health disparity;Cardiovascular Diseases;cardiovascular disorder risk;career;career development;Chronic Disease;cohort;college;Communities;community academic partnership;community engagement;community partners;Competence;concept mapping;Consult;cultural equity;Data;design;Development;disease disparity;Disparity;Disparity population;Diverse Workforce;diversity and inclusion;Equity;ethnic disparity;Ethnic Population;Evaluation;evidence base;Funding;Goals;Grant;Grant Review;Grant Review Process;Health;health care availability;Health Disparities Research;health disparity;health equity;Health Policy;Health Promotion;Historically Black Colleges and Universities;Human Rights;Improve Access;Individual;Inequity;Infrastructure;innovation;Institution;Institutional Policy;Intervention;lens;Link;Malignant Neoplasms;Medical;member;Mentors;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;National Institute on Minority Health and Health Disparities;network models;novel;Performance;Pilot Projects;Process;Process Assessment;Productivity;programs;Race;racial disparity;racial population;Readiness;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;research study;response;Risk Factors;Rural;Science;Secure;skills;social;social disparities;Social Justice;social structure;Strategic Planning;structural determinants;Structure;success;Support Groups;System;Training;training opportunity;Training Programs;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Woman;Work;Workforce Development;Writing

PROJECT_TITLE: Investigator Development Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: MADISON

ORG_NAME: MORGRIDGE INSTITUTE FOR RESEARCH, INC.

ORG_STATE: WI

PHR: Project Narrative The proposed project is broadly relevant to public health as a critical advancement of technology to enable basic biomedical research across therapeutic areas. This effort creates a computational platform to reduce the overall cost and improve the quality of high-throughput screening in any chemical biology or drug discovery project, which will be rigorously compared to existing experimental techniques. Modern data science tools will reduce the barriers to high-throughput screening and make screening for new compounds available to academic research groups in ways and in places where it has previously been inaccessible.

PI_NAMEs: GITTER, ANTHONY JAMES (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Acceleration;Active Learning;Algorithm Design;Algorithms;Area;Biological;Biological Assay;Biology;Biomedical Research;Body System;Budgets;candidate identification;Chemicals;computational platform;Computer software;computerized tools;Computing Methodologies;cost;cost effective;Data;Data Science;Data Set;design;Development;Disease;drug discovery;drug testing;Ensure;Equilibrium;follow-up;Funding;Goals;high throughput screening;improved;innovation;lead optimization;Learning;Libraries;Machine Learning;machine learning model;Methods;Modeling;Modernization;novel;novel therapeutics;open data;open source;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenotype;prevent;Process;Protac;protein degradation;prototype;Psychological reinforcement;PubChem;Public Health;Research;Research Personnel;Resources;scaffold;screening;Screening Result;small molecule libraries;Specificity;System;Techniques;Technology;technology development;Testing;Therapeutic;therapeutic target;three dimensional structure;Time;tool;United States National Institutes of Health;virtual library;virtual screening;wasting

PROJECT_TITLE: A Machine Learning Platform for Adaptive Chemical Screening

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: 8. Project Narrative: Overall The increased life expectancy of older Americans makes the maintenance of functional independence a major public health priority. The functional impairments and disabilities that occur in older people can emanate from acute events, such as stroke, heart attack, and hip fracture, or reflect the progression of chronic diseases. The UM-OAIC’s outstanding environment for research and research training in geriatrics, exercise, and rehabilitation sciences allows investigators from multiple disciplines to work together to develop and test novel exercise and activity-based and multi-modal rehabilitation interventions to restore function and minimize disability following acute disabling events and gradual declines related to serious chronic diseases.

PI_NAMEs: KATZEL, LESLIE I.;MAGAZINER, JAY  (contact);RYAN, ALICE S.

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Academy;Acute;Aerobic;Affect;Aging;aging process;American;Animal Model;animal old age;Area;bench to bedside;Biometry;Body System;Capsicum;career;Caring;Cessation of life;Chronic Disease;Clinic;Clinical;clinical center;clinically relevant;Collaborations;Communities;community advisory board;community setting;Degenerative polyarthritis;design;Development;disability;disabled;Disablement;Disabling;Disabling condition;disabling disease;Discipline;Disease Pathway;education research;efficacy testing;Engineering;Enrollment;Environment;Evaluation;Event;Exercise;Faculty;Fatigue;frailty;functional disability;Functional impairment;functional improvement;functional independence;functional restoration;Funding;Future;Geriatrics;Health Promotion;Heart failure;Hip Fractures;Home;Impaired cognition;Impairment;improved;industry partner;Informatics;innovation;Institutionalization;Intervention;Knowledge;Laboratories;Leadership;Life Expectancy;Maintenance;Malignant Neoplasms;Maryland;Medical;Mentors;Mission;multimodality;Myocardial Infarction;Neuronal Plasticity;new technology;next generation;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;older adult;Older Population;operation;Outcome;Parkinson Disease;physical impairment;Physiological;Physiology;pre-clinical;prevent;Prevention;Process;programs;public health priorities;rehabilitation research;rehabilitation science;rehabilitation technology;Rehabilitation therapy;Research;Research Personnel;Research Training;Resources;restoration;Risk;Robotics;sarcopenia;SARS-CoV-2 infection;Scientist;Services;Stroke;Technology;Testing;Training;Translating;translational pipeline;Translational Research;Treatment Efficacy;Underrepresented Minority;Universities;Vascular Diseases;Work

PROJECT_TITLE: University of Maryland Claude D. Pepper Older Americans Independence Center (OAIC)


NIH_SPENDING_CATS: Aging;Disability Research;Patient Safety;Physical Activity;Physical Rehabilitation;Rehabilitation

PI_NAMEs: MAGAZINER, JAY  (contact)

PROJECT_TERMS: Acute;Adherence;Advisory Committees;Affect;Aging;aging process;American;Area;Baltimore;Basic Science;Body System;Budgets;Capsicum;career;Career Mobility;Charge;Chronic Disease;Clinical;Clinical Protocols;Clinical Research;Clinical Trials Data Monitoring Committees;Collaborations;Communities;community advisory board;data quality;data quality/integrity;Development;disability;disabled;Disabling;Disabling condition;Discipline;Doctor of Philosophy;Education;education research;Ensure;Epidemiologist;Ethics;Evaluation;Event;Exercise;exercise physiologist;experience;Faculty;Financial Support;Fostering;Functional impairment;functional restoration;Funding;Goals;Health Promotion;innovation;interest;Intervention;Laboratory Research;Leadership;Maryland;Medical;meetings;member;Mission;Monitor;multidisciplinary;multimodality;next generation;novel;older adult;Older Population;operation;outreach;patient safety;Performance;Personal Satisfaction;Physical activity;Pilot Projects;Policies;Population;Productivity;programs;Progress Reports;Recovery of Function;recruit;Regulation;Rehabilitation therapy;Reporting;Research;Research Design;Research Personnel;Research Training;Resource Allocation;Resources;Rest;Safety;safety study;Science;Scientist;senior faculty;skills;Testing;Therapeutic;Training;Training Activity;Training Support;Translational Research;translational scientist;Universities;Work

PROJECT_TITLE: Leadership Administration Core


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative Using a hybrid type 1 effectiveness-implementation trial employing a stepped wedge cluster randomized design, we will examine effectiveness and implementation of a faith-based depression intervention among African Americans delivered in churches. Five church groups, each with 24 people (N=120) is the sample. If validated, this intervention will be the first evidence-based, faith-based intervention for African Americans.

PI_NAMEs: WARD, EARLISE C (contact)

PROGRAM_OFFICER_NAME: COA, KISHA

PROJECT_TITLE: Cognitive Behavioral Faith-based Depression Intervention For African American Adults (CB-FAITH): An Effectiveness And Implementation Trial

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: BRYANT-MOORE, KENESHIA  (contact)

PROJECT_TERMS: Address;Adopted;Affect;African American population;Alcohol consumption;Arkansas;Black Populations;Cardiovascular Diseases;career;Caregivers;Chronic Disease;Clinical and Translational Science Awards;Collaborations;Communication;Communities;community academic partnership;community building;community engaged approach;community engaged research;community engagement;community organizations;community partners;concept mapping;Consultations;County;Data Collection;Decision Making;Development;Development Plans;disease disparity;Disparity;disparity elimination;dissemination strategy;diversity and equity;Environment;Equity;Evaluation;experience;Failure;Foundations;Funding;Geographic Information Systems;Goals;Health;Health Disparities Research;health disparity;Health Promotion;Human Rights;improved;Individual;innovation;Institution;Intervention;Knowledge;lens;Malignant Neoplasms;Maps;Medical;member;Methods;Modeling;National Institute on Minority Health and Health Disparities;novel;novel strategies;Obesity;Outcome;Outcome Study;Participant;Pilot Projects;Policies;Policy Maker;Process;Public Health;Publishing;racial disparity;Recording of previous events;Research;Research Design;Research Institute;Research Personnel;Research Project Grants;Resources;Risk Factors;Rural;rural area;Science;shared decision making;skills;Social Justice;social structure;Solid;Strategic Planning;symposium;System;therapy design;Tobacco use;Training;training opportunity;Translating;Translational Research;Translations;Trust;Universities;uptake;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Malaria;Pediatric;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE This research has high public health significance in malaria endemic regions of sub-Saharan Africa since it will advance our understanding of the innate immune mechanisms by which chronic Plasmodium falciparum blood stage infection is maintained in healthy asymptomatic school-age children. Children in this age group are the single most important reservoir of ongoing P. falciparum transmission to mosquito vectors. Results of this study are pertinent to the control and ultimate elimination of malaria.

PI_NAMEs: GOLENBOCK, DOUGLAS T;KAZURA, JAMES WALTER (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: 15 year old;adaptive immunity;Address;Affect;Africa;Africa South of the Sahara;Age;age group;age stratification;Agonist;Anopheles Genus;antagonist;Anti-Inflammatory Agents;Area;Binding Sites;Biological Assay;Biomass;Blood;Blood specimen;Cells;Child;Chromatin;chromatin immunoprecipitation;Chronic;Clinical;cohort;Collecting Cell;Communities;comparison group;Complex;County;Culicidae;cytokine;Cytokine Gene;Cytometry;Data;Development;Disease;DNA;DNA sequencing;effector T cell;Elements;Enhancers;Enrollment;Epidemiology;epigenetic marker;Epigenetic Process;epigenome;Equilibrium;Fever;Gene Expression;Gene Expression Profile;Genes;Goals;High-Throughput Nucleotide Sequencing;Homeostasis;Immune;Immunomodulators;In Vitro;Individual;Infection;Inflammation Mediators;Inflammatory;inflammatory modulation;Inflammatory Response;innate immune mechanisms;innate immune pathways;Innate Immune Response;insight;Interferon Type II;Interferons;Interleukin-1 Receptors;Interleukin-10;Interleukin-6;Kenya;Knowledge;Legal patent;Longitudinal cohort study;Malaria;Measurement;Modification;monocyte;Parasitemia;Parasites;Pathway interactions;Peripheral Blood Mononuclear Cell;Plasma;Plasmodium falciparum;Population;Production;programs;promoter;Proteins;Public Health;Regulator Genes;Regulatory Pathway;Regulatory T-Lymphocyte;Research;response;Role;rural area;School-Age Population;Schools;sex;Site;Source;Specificity;Symptoms;T-Lymphocyte Subsets;Testing;Tissue-Specific Gene Expression;TNF gene;Toll-like receptors;transcription factor;transcriptome sequencing;transmission process;Transposase;vector;vector mosquito;Work

PROJECT_TITLE: Innate Immune Mechanisms Governing Subclinical Malaria in Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-E(02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: LONG, CHRISTOPHER  (contact)

PROJECT_TERMS: Acceleration;Accounting;Address;Age;Agreement;Arkansas;behavioral economics;Body mass index;Cardiovascular Diseases;Carotenoids;Child;Chronic Disease;cluster randomized design;Cluster randomized trial;Communities;Consolidated Framework for Implementation Research;Consumption;Data;Data Collection;Databases;Diabetes Mellitus;Diet Habits;Dietary Intervention;disease disparity;Disparity;Economics;effective intervention;effectiveness evaluation;Eligibility Determination;Ensure;Environment;Equity;Ethnic Origin;Evaluation;evidence base;Exhibits;experience;Face;follow-up;Food;food consumption;food quality;Food Services;fruits and vegetables;Funding;Guidelines;Health;health disparity;Health Food;Healthy Eating;Heterogeneity;High School Student;Household;Human Rights;implementation intervention;implementation study;Improve Access;improved;Incidence;indexing;Individual;innovation;Intake;Intervention;K-12 student;Long-Term Effects;Low income;Malignant Neoplasms;Measures;Menu Planning;Methodology;Modeling;Modification;mortality;multidisciplinary;National Institute on Minority Health and Health Disparities;nutrition;Nutrition Policy;Nutritional;Obesity;obesity prevention;obesity risk;obesity treatment;Outcome;overweight adults;Persons;Policies;Population;population based;Prevalence;Price;Process;programs;Race;Recipe;Research;Research Project Grants;Resources;Risk;Rural;rural area;Rural Community;rural counties;Rural Population;rural residence;school district;Schools;Science;sex;Skin;social;Social Justice;social structure;Students;synergism;Testing;theories;therapy design;Time;Translating;Translations;treatment effect;United States;United States Department of Agriculture;wasting

PROJECT_TITLE: Evaluation of a Comprehensive School Nutrition Enrichment Intervention (CSNEI) in Rural School Districts


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE  The proposed conference series is designed to increase the pipeline of underrepresented minority (URM) researchers in conducting population-based research with statewide registries to advance the science on Alzheimer’s disease and related dementias (ADRD)-related disparities. The two-day meeting will begin by offering an overview of the three existing statewide AD registries in the United States (US), with the second day designed as an interactive workshop for URM researchers in which scientist-mentor teams will be established to facilitate the development of mentored research projects using AD registry data. Our ultimate goal in diversifying the research workforce in aging and ADRD is to ensure that the community of scientists is representative of the entire US population. 1

PI_NAMEs: FRIEDMAN, DANIELA B. (contact);INGRAM, LUCY ANNANG;LEVKOFF, SUE E

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Affect;African American population;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Behavioral;biodemography;brain research;California;Cardiovascular system;career;Centers for Disease Control and Prevention (U.S.);cognitive function;Collaborations;Communities;Data;data registry;Dementia;Demographic Factors;design;Development;Disparity;Economics;Education;education research;Educational workshop;Environmental Risk Factor;Faculty;Funding;Goals;Health;Health Disparities Research;health disparity;Health Services Accessibility;Historically Black Colleges and Universities;improved;Individual;interest;Journals;Lead;Leadership;Learning;Manuscripts;Maps;Medical;meetings;member;Mentors;Mentorship;middle age;Minority;Minority Health Research;minority investigator;Modification;National Institute on Aging;older adult;Outcome;Pathway interactions;Peer Review;Population;population health;Population Research;Population Study;Poverty;Process;Program Evaluation;programs;psychologic;Public Health;public health priorities;Publications;Registries;Research;Research Personnel;Research Project Grants;Research Training;Resources;Scholarship;Science;Scientist;senior faculty;Series;social;South Carolina;Southeastern United States;symposium;Training;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States;Universities;West Virginia

PROJECT_TITLE: Promoting High-Impact Alzheimer's Disease Research through the Use of Statewide Registries: Expanding Diversity in Aging Research.


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infant Mortality;Mental Health;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Social Determinants of Health;Sudden Infant Death Syndrome;Women's Health Research

ORG_CITY: WORCESTER

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE We propose a 1:1 randomized control trial of financial transfers of $160 per week among 420 low-income mothers with preterm infants 25-33 weeks’ gestation versus standard of care (control) during the preterm birth hospitalization. The financial transfer will be “labelled” with one-time message that the transfer is intended for them to visit and care for their hospitalized infant. This simple intervention will test the hypothesis that low- income mothers do not have access to crucial caregiving behaviors linked to improve preterm infant health and development—breastfeeding and skin-to-skin care—because of the acute financial stress faced after preterm birth limits their ability to visit the hospital.

PI_NAMEs: MCCONNELL, MARGARET ;PARKER, MARGARET GRAHAM KEMPER (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Adherence;arm;Attention;Back to Sleep;Behavior;Birth;Breast Feeding;breast pump;caregiving;Caring;Child;Child Care;Child Development;Child Health;Childhood;Clinical;cognitive function;Control Groups;cost;Cost Analysis;Development;Developmental Disabilities;Disparity;economic disparity;effectiveness testing;enhanced care;Equity;Failure;Family;feasibility trial;Financial Hardship;group intervention;Health;Health Benefit;health care availability;health care service utilization;Health Promotion;Health system;hospital readmission;Hospitalization;Hospitals;Hour;Human Milk;improved;Incidence;Income;Infant;Infant Care;Infant Development;Infant Health;innovation;interest;Intervention;Label;Length of Stay;Link;Location;Low income;lower income families;Massachusetts;maternal caregiving;Mediating;Mediator;Medicaid eligibility;Medical Care Costs;Memory;Mental Depression;Mental Health;milk production;Modeling;Morbidity - disease rate;mortality;Mothers;Neonatal Intensive Care Units;neurodevelopment;Outcome;Physiological;Pilot Projects;Population;Pregnancy;Premature Birth;Premature Infant;primary outcome;program costs;programs;psychologic;Psychological Impact;Quality of Care;randomized trial;Randomized, Controlled Trials;Reduce health disparities;Reporting;Research;Risk;Rural;secondary outcome;Shoulder;Skin;Skin Care;sleep position;socioeconomic disparity;standard care;standard of care;Stress;suburb;Testing;Time;Training;Transportation;treatment arm;treatment as usual;United States;Visit

PROJECT_TITLE: Effect of support for low-income mothers of preterm infants on parental caregiving in the NICU

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Aging

PI_NAMEs: SORKIN, JOHN D. (contact)

PROJECT_TERMS: Adverse event;Aging;American;Area;authority;Big Data;Bioinformatics;Biomedical Research;Biometry;Biostatistical Methods;Capsicum;Clinical Trials;Collaborations;Conduct Clinical Trials;Data;Data Analyses;data management;data repository;Databases;design;Disabling condition;Doctor of Philosophy;Documentation;Education;Educational process of instructing;Engineering;Epidemiologist;Epidemiology;Equilibrium;experience;Faculty;functional independence;Funding;Gait;Goals;Health Promotion;Individual;Informatics;informatics infrastructure;Infrastructure;innovation;Laboratories;Maintenance;Manuscripts;Maryland;member;Mentors;Methodology;Methods;Mission;Modeling;Monitor;next generation;older adult;Older Population;Online Systems;operation;Participant;participant enrollment;participant retention;Patient Recruitments;Performance;Pilot Projects;Play;Population;preclinical study;Preparation;programs;Progress Reports;protocol development;Publishing;Randomized;recruit;Registries;Rehabilitation therapy;Reporting;Reproducibility;Research;research and development;Research Design;Research Personnel;Research Project Grants;research study;Research Support;Research Training;Resource Informatics;Role;Sample Size;Scientist;Services;Statistical Data Interpretation;statistics;Support Groups;System;Technology;technology development;Training;Training Activity;Training Programs;Universities;Work;working group

PROJECT_TITLE: Biostatistics and Informatics


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

PHR: Project Narrative: We have no reliable vaccine to prevent tuberculosis (TB), a disease that kills 1.4 million people every year. As CD4 T cells are critical for protection against active TB, a key research priority that would accelerate vaccine development is to determine which attributes of the memory CD4 T cell response are critical to prevent progression to active TB. This project seeks to define protective memory T cell function by applying cutting edge single-cell analyses to track and compare Mycobacterium tuberculosis-specific memory CD4 T cells among individuals that will later progress to active TB vs. those that have not developed TB despite heavy exposure.

PI_NAMEs: CARPENTER, STEPHEN MATTHEW (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Acceleration;Adolescent;Adult;Animal Model;antigen-specific T cells;Antigens;Autologous;Avidity;Benchmarking;Bioinformatics;Biological Models;Bronchoalveolar Lavage Fluid;CD4 Positive T Lymphocytes;Cell Physiology;Cell Separation;Cells;Cellular biology;Cessation of life;Chronic;chronic infection;Clinical;Clinical Investigator Award;Clinical Research;Coculture Techniques;cohort;Collaborations;Communicable Diseases;Communities;cytokine;Cytoprotection;Data;Development;Disease;effector T cell;Environment;experience;experimental study;fighting;Flow Cytometry;Frequencies;Funding;Goals;HIV;Household;Human;Immune;Immunologist;Immunology;improved;Individual;Infection;Institution;Learning;Link;Lung;Lymphocyte;Macrophage;medical schools;memory CD4 T lymphocyte;Mentors;mouse model;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Peptide/MHC Complex;Peptides;Persons;Phenotype;Physicians;Positioning Attribute;Predisposition;Preparation;prevent;Prevention;programs;recruit;Research;Research Personnel;Research Priority;risk stratification;Severities;single cell analysis;single-cell RNA sequencing;skills;Specificity;System;T cell response;T memory cell;T-Cell Antigen Receptor Specificity;T-Cell Depletion;T-Cell Receptor;T-Lymphocyte;Testing;Training;transcriptome sequencing;transcriptomics;Translational Research;Tuberculosis;Tuberculosis Vaccines;Uganda;Universities;vaccine candidate;Vaccine Design;vaccine development;Vaccines;Work

PROJECT_TITLE: Determining Protective Features of Human Memory T-cells to Inform Mycobacterium tuberculosis Vaccine Development

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Better understanding of brain mechanisms for memory formation is needed to accelerate progress in the treatment of memory impairments caused by neurologic and psychiatric disorders. This project involves basic experiments in individuals with neurosurgical depth electrodes to determine how the human hippocampus interacts with brain networks to drive the active sampling process that is essential for memory formation. Findings will be relevant to the understanding and treatment of memory impairment.

PI_NAMEs: VOSS, JOEL L (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Acceleration;Address;Attention;Automobile Driving;Behavior;Binding;Brain;Brain Injuries;clinical care;Cognitive;Communication;Coupled;design;Development;Dorsal;effective therapy;Electric Stimulation;Electrodes;Electroencephalography;Elements;Environment;Epilepsy;Episodic memory;episodic memory impairment;Event;Experimental Designs;experimental study;Eye Movements;Frequencies;Goals;Grain;Hippocampus;Human;Impairment;improved;indexing;Individual;innovation;interest;Knowledge;long term memory;Measures;Memory;Memory Disorders;memory encoding;Memory impairment;memory process;memory retrieval;Mental disorders;millisecond;Nerve Degeneration;Nervous System Disorder;neural;neural correlate;neuromechanism;neurosurgery;Neurosurgical Procedures;neurotransmission;novel;novel strategies;Pattern;Perception;Phase;Post-Traumatic Stress Disorders;Process;Property;relational memory;Research;Resolution;Retrieval;Role;Saccades;sample fixation;Sampling;Schizophrenia;Short-Term Memory;Signal Transduction;spatiotemporal;Stimulus;support network;Technology;temporal measurement;Testing;Time;Visual;visual information;visual learning;visual processing;visual tracking;Visuospatial

PROJECT_TITLE: Human hippocampal contributions to rapid encoding-retrieval interactions during memory formation

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Disability Research;Neurosciences;Nutrition;Osteoporosis;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

PI_NAMEs: RYAN, ALICE S. (contact)

PROJECT_TERMS: Acceleration;Acute;Aerobic;age related;Aging;Alzheimer's disease related dementia;American;Animal Model;animal tissue;Arthritis;Atrial Fibrillation;Basic Science;Biochemical;Biological Assay;Blood;Body Composition;burden of chronic illness;Capsicum;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular fitness;Cardiovascular system;Chronic;Chronic disability;Chronic Disease;Clinical;clinical center;clinical outcome measures;Clinical Research;clinical translation;clinically relevant;community setting;comorbidity;Congestive Heart Failure;COVID-19;deconditioning;Development;Diabetes Mellitus;disability;disability risk;disabled;Disabled Persons;Disabling condition;disabling disease;Disease;disorder risk;economic impact;Eligibility Determination;Endocrine;Ensure;Event;Evidence based intervention;Exercise;exercise training;Faculty;falls;functional decline;functional disability;functional independence;functional restoration;Funding;Goals;Grant;Hip Fractures;HIV;Home;Human;human tissue;improved;In Vitro;in vivo;Individual;Inflammation;innovation;Intensive Care Units;Interdisciplinary Education;Interdisciplinary Study;Intervention;Knowledge;laboratory experience;Link;Malignant Neoplasms;Maryland;Measures;Medical;Mentors;Metabolic dysfunction;metabolic phenotype;Methodology;Mission;mode of exercise;Modeling;Molecular;multidisciplinary;multimodality;Muscle;Musculoskeletal;neuromuscular;novel;Obesity;older adult;Older Population;Osteoporosis;Outcome;Outcome Measure;Paper;Participant;patient safety;Patients;Performance;Peripheral arterial disease;Phenotype;Physical activity;Physiological;Physiology;Pilot Projects;pre-clinical;prevent;Prevention;Property;Protocols documentation;Publications;Quality of life;Recovery;rehabilitation strategy;Rehabilitation therapy;Research;Research Design;Research Personnel;Research Support;Resistance;Resources;restoration;Rodent Model;sarcopenia;screening;Services;Severities;socioeconomics;Stroke;System;Testing;Tissues;Training;Translating;Translational Research;Traumatic Brain Injury;United States National Institutes of Health;Universities;ward;Work

PROJECT_TITLE: Applied Physiology and Mechanisms


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Lung Cancer;Mental Health;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

PI_NAMEs: FAGAN, PEBBLES  (contact)

PROJECT_TERMS: Abstinence;abuse liability;access disparities;Acetaldehyde;Acrolein;Address;African American;African American population;Arkansas;arm;attributable mortality;Benzaldehyde;Biological Markers;Black Populations;Black race;Body mass index;Cancer Etiology;cancer health disparity;cancer prevention;cancer risk;Carbon Monoxide;Cessation of life;Chronic Disease;Cigarette;cigarette smoking;community academic partnership;Community Trial;Consumption;Cotinine;Counseling;County;COVID-19 pandemic;craving;Death Rate;Discrimination;Disparity;Dose;Education;effective intervention;efficacy testing;Equity;evidence base;Evidence based intervention;experience;Face;Failure;Food;Food Access;food insecurity;food security;Formaldehyde;Foundations;fruits and vegetables;Goals;Health;health care availability;health disparity;Health Food;Healthcare;Home;hydroxycotinine;improved;Income;Inequity;innovation;Intervention;intervention delivery;Knowledge;Malignant Neoplasms;marginalized population;Measures;Medical;Modeling;Morbidity - disease rate;mortality;Motivation;multidisciplinary;National Institute on Minority Health and Health Disparities;Nicotine Dependence;novel;perceived discrimination;Population;Poverty;Prevalence;Preventable cancer cause;programs;randomized controlled design;recruit;reduce tobacco use;Research;Resources;Risk Behaviors;Role;Rural;rural African American;rural counties;Science;Smoker;Smoking;smoking abstinence;smoking cessation;smoking prevalence;social;Social Change;Social Conditions;social disparities;social factors;social interventions;Social Justice;social stressor;social structure;stressor;Structural Racism;System;Testing;Time;Tobacco;tobacco exposure;tobacco-free;Transportation;treatment group;trend;Unemployment;United States;Universities;voucher;Withdrawal

PROJECT_TITLE: FRESH Delivers: An Innovative Approach to Reducing Tobacco Use Among Rural Black/African American Smokers


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Services

ORG_DEPT: UROLOGY

PHR: PROJECT NARRATIVE The University of Michigan’s UroEPI program (K12), directed by Drs. Aruna V. Sarma and J. Quentin Clemens, brings together the necessary mentors, resources and units to inspire and train urologists to pursue an academic career in the epidemiology of benign urological conditions. As a K12 program that is focused on training urologists and scientists in epidemiological methods, the demand for training will be considerable. This program will offer a two-year training track to meet the needs of scholars. With this support, we will provide the next generation of physician-scientists with the essential skills to address important clinical and translational epidemiological research questions.

PI_NAMEs: CLEMENS, J. QUENTIN ;SARMA, ARUNA V (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: bench-to-bedside translation;Benign;Biometry;career;career development;Clinical;clinical practice;comparative effectiveness;Conceptions;Dissemination and Implementation;Environment;Epidemiology;epidemiology study;Ethics;experience;faculty mentor;Health Benefit;Health Sciences;Health Services;Healthcare;implementation research;Institution;Medical;Mentored Clinical Scientist Development Program;Mentors;Methodology;Michigan;Monitor;Peer Review;Philosophy;population health;Positioning Attribute;Program Development;programs;Public Health;Publications;Research;Research Design;Research Personnel;Research Project Grants;Review Literature;Scientist;skills;Social Sciences;symposium;Technical Expertise;Techniques;Testing;theories;Training;Training Programs;Translating;Universities;urologic;Urology;Work

PROJECT_TITLE: University of Michigan UroEPI Career Development Program

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Aging;Arthritis;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Activity;Physical Rehabilitation;Precision Medicine;Regenerative Medicine;Rehabilitation;Stroke

PI_NAMEs: MACKO, RICHARD FRANK (contact)

PROJECT_TERMS: Acceleration;Aerobic Exercise;Aging;American;Ankle;Arthritis;Artificial Intelligence;Biomechanics;Biomedical Engineering;Blood Vessels;brain health;Capsicum;Cardiovascular system;Caring;Chronic;Chronic Disease;chronic stroke;Collaborations;college;Community Practice;Computer Vision Systems;design;Development;digital health;disability;disabling disease;Discipline;Elements;Emerging Technologies;Engineering;Enhancement Technology;Equilibrium;evidence base;Evidence based practice;Exercise;functional improvement;functional independence;functional loss;functional restoration;Gait;Geriatrics;Goals;Guidelines;Health;Hip Fractures;human old age (65+);improved;Informatics;innovation;Intervention;Investigation;joint function;Joints;Knowledge;Learning;Locomotion;Machine Learning;Maryland;Mediating;Mentors;Metabolic;Mission;mobile sensor;Modeling;Motor Activity;motor learning;multidisciplinary;Muscle;Neurology;neuromuscular;neuromuscular system;Neuronal Plasticity;Neurosciences;new technology;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;older adult;Older Population;Parkinson Disease;patient stratification;Performance;Peripheral;personalized diagnostics;personalized therapeutic;Phase;Physical activity;Physical Exercise;physical impairment;Physical Medicine;physical therapist;Physical therapy;Physiological;Precision therapeutics;prevent;Privatization;Process;Public Health;Recommendation;Recovery;Recovery of Function;rehabilitation engineering;rehabilitation science;rehabilitation technology;Rehabilitation therapy;rehabilitative care;Research;research clinical testing;Research Personnel;Resources;robot rehabilitation;Robotics;Science;Scientist;sedentary lifestyle;Services;Stroke;stroke patient;synergism;System;Technology;Technology Transfer;Tendon structure;Testing;Therapeutic;tool;Training;Training Activity;Translating;Translational Research;Translations;Universities

PROJECT_TITLE: Rehabilitation Science and Technologies


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis

PHR: The proposed research is relevant to public health because it seeks to develop new tracking methods and diagnostics to identify new M. tuberculosis infection. These innovations would allow for feasible and targeted treatment of M. tuberculosis infection with the potential to decrease TB transmission and ultimately impact global TB incidence.

PI_NAMEs: BARK, CHARLES MARTYN (contact);KIWANUKA, NOAH ;WHALEN, CHRISTOPHER C.

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Address;Adult;Africa South of the Sahara;African;Area;Bacille Calmette-Guerin vaccination;Behavior;Biological Markers;Biological Sciences;biomarker development;biomarker signature;burden of illness;case control;Cause of Death;Child;cohort;Cohort Studies;Communicable Diseases;Communities;cytokine;design;Detection;Development;Diagnosis;Diagnostic;Disease;Disease Progression;disorder risk;Disparity;effective intervention;Effectiveness;Enrollment;Environment;Epidemic;Epidemiology;Event;experience;Face;follow-up;Goals;health care settings;high risk;HIV;HIV Seropositivity;HIV/TB;Household;Immune response;Immunology;improved;Incidence;Individual;Infection;innovation;isoniazid;latent infection;Maps;Measures;Methods;Mycobacterium tuberculosis;next generation;Pattern;Persons;Plasma;Population;prevent;Preventive therapy;progression risk;Progressive Disease;Proteins;Proteomics;Public Health;Random Allocation;Recommendation;Regimen;Research;response;Risk Reduction;Sampling;Serum;social;targeted treatment;Technology;Testing;Time;transmission process;Tuberculin Test;Tuberculosis;Uganda;Universities;World Health Organization

PROJECT_TITLE: Capturing spatial patterns of new M. tuberculosis  infection in Kampala, Uganda

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-R(50)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse

PI_NAMEs: HAYNES, TIFFANY FRANCINE (contact)

PROJECT_TERMS: Address;African American;Aftercare;alcohol risk reduction;Alcohols;Arkansas;Back;Barbering;barrier to care;Beauty;binge drinking;black men;Caring;Cessation of life;Chronic Disease;Clinical;Communities;community setting;community-level factor;Consolidated Framework for Implementation Research;Consumption;County;Coupled;cultural competence;Data;design;Development;Discrimination;Disease;disease disparity;disparity reduction;drinking;Early Intervention;effectiveness evaluation;effectiveness testing;effectiveness/implementation trial;Emergency Care;Equity;Ethnic Population;Evaluation;evidence base;Evidence based intervention;experience;Exposure to;Feedback;Focus Groups;Foundations;Geography;Goals;Health;health disparity;Health Promotion;Heavy Drinking;high risk drinking;Human Rights;Hybrids;implementation strategy;improved;Individual;Instruction;Insurance Coverage;Intervention;Knowledge;Life;Link;Low income;Malignant Neoplasms;Measures;Medical;men;Mental Health;Minority;model design;Modeling;Morbidity - disease rate;mortality;mortality risk;National Institute on Minority Health and Health Disparities;Outcome;Poverty;Primary Care;primary outcome;Process;Public Health;racial population;racism;Randomized, Controlled Trials;reduced alcohol use;Reporting;Research;Research Project Grants;research to practice;Resources;Risk;Rural;rural area;Rural Community;rural counties;Science;screening, brief intervention, referral, and treatment;service intervention;Services;social;social disparities;social interventions;Social Justice;social structure;Social support;Structure;Substance abuse problem;synergism;Testing;timeline;Training;Translating;Trust;United States;usual care arm;Waiting Lists

PROJECT_TITLE: Reducing Alcohol Use among Black Men: Barbershop SBIRT


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: AMES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE Coronavirus exoribonuclease (ExoN) complex is essential for the virus life cycle and represents a promising target for anti-coronavirus therapies. However, many fundamental aspects of this unique enzyme remain uncharacterized. This proposed research program aims to delineate the structural and molecular basis of multiple key processes mediated by ExoN complex during SARS-CoV-2 genome replication and transcription, which will provide insights into the development of new therapeutic strategies to fight the current and future coronaviruses.

PI_NAMEs: YANG, YANG  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 2019-nCoV;Biochemical;Biological Models;Biology;Biophysics;Cells;cofactor;Complex;Coronavirus;coronavirus treatment;Coupled;Coupling;Cryoelectron Microscopy;Development;Digestion;dimer;Dissection;Enzymes;Exoribonucleases;experimental study;fighting;Future;Genetic Transcription;Genome;Goals;Immune Evasion;insight;Life Cycle Stages;Link;Mediating;Molecular;novel therapeutic intervention;nucleotide analog;Nucleotides;Physiological;Play;Polymerase;Process;programs;Proteins;Regulation;Research;RNA;RNA Biochemistry;RNA Caps;RNA chemical synthesis;RNA Processing;RNA Proof-Reading;RNA Viruses;Role;SARS-CoV-2 genome;single molecule;Structure;targeted treatment;Therapeutic Intervention;tool;Viral;Viral Genome;Viral Nonstructural Proteins;viral RNA;virology;Virus

PROJECT_TITLE: Mechanistic insights into multifaceted roles of coronavirus exoribonuclease complex

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Clinical Research;Disability Research;Osteoarthritis;Physical Rehabilitation;Rehabilitation;Telehealth

PI_NAMEs: SELIGER, STEPHEN L. (contact)

PROJECT_TERMS: Acute;Adherence;Affect;age related biomarkers;Aging;aging mechanism;aging related;Ally;American;Animals;Applications Grants;Baltimore;Body System;Capsicum;career;Caregivers;Cells;Chronic;Clinic;Clinical;Collaborations;Communities;community advisory board;Community Practice;Consultations;Critical Care;Data;Data Collection;Degenerative polyarthritis;design;Development;disability;Disabling condition;Discipline;Disease;education research;efficacious treatment;Ensure;Epidemiology;Ethics;Exercise;Extramural Activities;Faculty;Functional disorder;functional outcomes;functional restoration;Funding;Future;Goals;Home;hospital readmission;Human;human model;Impairment;innovation;Intensive Care Units;interdisciplinary collaboration;Interdisciplinary Study;interest;Intervention;Investigation;Knee Osteoarthritis;Laboratories;Leadership;Lung;Manuals;Maryland;Mechanics;Medical center;Medicine;member;Mental Depression;Mentors;Methodology;Methods;Monitor;multimodality;older adult;Orthopedics;Pain;participant enrollment;participant retention;Patient Recruitments;Peer Review;Performance;Pilot Projects;Pre-Clinical Model;Preventive Medicine;Privacy;Procedures;Process;programs;Public Health;Randomized, Controlled Trials;Recovery;rehabilitation research;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Resources;Safety;Structure;Support Groups;Survivors;System;Talents;Telemedicine;telerehabilitation;Testing;Therapeutic;Translating;Tubular formation;Universities;working group

PROJECT_TITLE: Pilot and Exploratory Studies Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Prevention;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Caregivers of individuals with Alzheimer's disease are at risk for loneliness, social isolation, and burden, all of which impact health and wellbeing and pose a growing public health problem. The proposed research will use Geographic Information Systems (GIS) technology, ethnography, and surveys to analyze and map caregivers' experiences in order to identify social and environmental factors that support caregivers or contribute to burden. Results will be used to design interventions for future studies to improve the lives, visibility, and resource use of caregivers of individuals with Alzheimer's disease and to address this pressing health and social need.

PI_NAMEs: SIDEMAN, ALISSA BERNSTEIN (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Anthropology;Applications Grants;Applied Research;Area;Behavior Therapy;Behavioral Mechanisms;California;Cardiovascular Diseases;care giving burden;career;Caregiver Burden;Caregiver support;Caregiver well-being;Caregivers;caregiving;Caring;clinical practice;Communities;community setting;Counseling;Data;Data Analyses;Data Sources;Dedications;Dementia;Dementia caregivers;dementia risk;Disease;Doctor of Philosophy;Domestic Partners;Education;Emotional;emotional experience;Engineering;Environment;environmental intervention;Environmental Risk Factor;Ethnography;experience;Family Caregiver;Family member;follow-up;Fostering;Friends;Future;Geographic Information Systems;Geography;Goals;Health;Health Policy;Hearing;high risk;Home;improved;Individual;innovation;Institution;Interdisciplinary Study;Intervention;Interview;K-Series Research Career Programs;Knowledge;knowledge integration;Loneliness;Maps;Medical;Mental Depression;Mentors;Mentorship;Methods;mortality;Movement;multidisciplinary;novel strategies;older adult;Outcome;Personal Satisfaction;Persons;Physical activity;Pilot Projects;Policies;Provider;Public Health;Qualifying;Quality of life;Research;Research Methodology;Research Personnel;Research Project Grants;resilience;Resources;Risk;Sampling;San Francisco;Science;Scientist;Services;skill acquisition;skills;social;social contact;social culture;social factors;social interventions;Social isolation;Social Network;Social Sciences;Social support;Spouse Caregiver;Surveys;Techniques;technology platform;therapy design;Time;tool;Training;Typology;United States;Universities;Visual;Wages

PROJECT_TITLE: Mapping the Dynamics of Caregiver Burden in Alzheimer's Disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA STATE DEPARTMENT OF HEALTH

ORG_STATE: IN

PHR: Project Narrative Between 2021 and 2026, based on the resources provided by the United States Food and Drug Administration (FDA) Cooperative Agreement PAR-21-127 and guidance issued by the National Association of State Departments of Agriculture (NASDA) model Produce Safety Implementation Framework, it is the goal of the Indiana Produce Safety Team to continue to advance the operation of the regulatory program as a Path C grantee, to ensure uniform and consistent application of the Produce Safety Rule (21 CFR 112), and most importantly to advance efforts for a national integrated food safety system.

PI_NAMEs: MCCURDY, VIVIEN  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, ANDREA

PROJECT_TITLE: Path C Indiana Produce Safety Cooperative Agreement Program (CAP)


ORG_CITY: RALEIGH

ORG_NAME: NC STATE DEPT OF AGRI AND CONSUMER SERV

ORG_STATE: NC

PHR: The Project Narrative This project, proposed by the North Carolina Department of Agriculture & Consumer Services (NCDA&CS), entitled NCDA&CS National Produce Safety CAP PATH C, is intended to continue the established Produce Safety Program to encourage safe production of fresh fruits and vegetables, promote compliance with the requirements of the Produce Safety Rule and improve public health protection. The NCDA&CS will continue their efforts to assess the North Carolina produce landscape, provide outreach, education and technical assistance to produce farms across the state, encourage verification of farm information and aim to achieve full compliance with the Produce Safety Rule by way of educational farm visits, regulatory inspections and other produce event response activities.

PI_NAMEs: MACMULLAN, ANITA  (contact)

PROGRAM_OFFICER_NAME: VARGO, ADRIANNA

PROJECT_TITLE: Path C NCDA&CS National Produce Safety CAP


NIH_SPENDING_CATS: Aging;Clinical Research

PI_NAMEs: ROGHMANN, MARY-CLAIRE  (contact)

PROJECT_TERMS: Academy;American;Baltimore;Capsicum;career;career development;Clinic;Clinical;college;Communication;Communities;County;Data;design;Development;Development Plans;disabled;Discipline;education research;Educational Curriculum;Educational process of instructing;Elements;Engineering;Ensure;Environment;Evaluation;experience;Faculty;Financial Support;Fostering;Functional impairment;functional improvement;Funding;Future;Goals;Impairment;improved;Individual;Institution;Interdisciplinary Study;interest;K-Series Research Career Programs;Laboratories;Lead;Leadership;Learning;Maryland;Measures;medical specialties;meetings;member;Mentors;Mission;multidisciplinary;next generation;novel;older adult;Older Population;Outcome;Peer Review;Pre-Clinical Model;prevent;Prevention;Program Development;programs;Publications;Recording of previous events;recruit;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Research Training;Resource Development;Resources;restoration;Scholars Program;Schools;Scientist;skills;Structure;Talents;Teacher Professional Development;Technology;Time;Training;Training Programs;Translational Research;Universities;Wages;working group

PROJECT_TITLE: Research Education Core


ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Cognitive load and burnout affect the well-being of clinicians and safety of patients under their care. Prior studies have relied predominantly relied on surveys for their measurement. We propose the use of electronic health record (EHR)-based audit logs to determine the cognitive load experienced by clinicians, assess its direct impact on errors using automated clinical decision support tools, and determine the mediating role of burnout in explaining the relationship between cognitive load and errors.

PI_NAMEs: KANNAMPALLIL, THOMAS GEORGE (contact)

PROGRAM_OFFICER_NAME: HAUGSTETTER, MONIKA

PROJECT_TITLE: Integrating real-time clinical activity and behavioral responses for characterizing cognitive load and errors (IGNITE)

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Lung;Lung Cancer

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative: We will leverage our expertise and resources to: i) Determine the biomarker value of measuring functional TIL profiles in human lung cancer; ii) Analyze the role of LAG-3/FGL1 interaction as immunomodulatory target; and iii) Analyze the role LAG-3 pathway and immune contexture in lung cancer progression.

PI_NAMEs: SCHALPER, KURT A (contact)

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: Acceleration;Address;Animals;anti-cancer treatment;anti-PD1 therapy;Antigens;Apoptosis;Autologous;Biological Assay;Biological Markers;Biological Models;Biopsy Specimen;cancer biomarkers;cancer immunobiology;cancer immunotherapy;carcinogenesis;Carcinoma in Situ;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cessation of life;Clinic;Clinical;clinical biomarkers;Clinical Trials;clinically significant;Collection;Computer Analysis;Cytometry;deprivation;design;Diagnosis;Effector Cell;Engraftment;Epithelial Cells;Functional disorder;Glucose;Human;Image;Immune;Immune Evasion;Immunity;immunodeficiency;Immunologic Markers;immunoregulation;Immunotherapy;in vivo;Induction of Apoptosis;Inflammation;inflammatory marker;innovation;Ligands;Lung;lung lesion;Malignant neoplasm of lung;Malignant Neoplasms;malignant phenotype;Maps;Measurement;Measures;Mediating;Modality;Morphology;mortality;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel marker;optimal treatments;Outcome;Oxygen;Pathology;Pathway interactions;Patient Selection;Patients;PD-1 blockade;PD-1/PD-L1;Peripheral;Peripheral Blood Mononuclear Cell;Population;premalignant;programmed cell death protein 1;programs;Property;receptor;Refractory;Resistance;Resources;response;Role;sample collection;Signal Induction;Signal Transduction;Slide;Stromal Cells;Structure of parenchyma of lung;T cell clonality;T cell receptor repertoire sequencing;T cell response;T-Cell Proliferation;T-Lymphocyte;Therapeutic Intervention;Tissue Microarray;Tissues;Translational Research;translational study;tumor;tumor progression;Tumor-Infiltrating Lymphocytes;Up-Regulation;Work

PROJECT_TITLE: Quantitative and Spatially-Resolved Analysis of the Tumor Immune Contexture for Optimal Diagnosis and Treatment of Lung Cancer

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Conditions Affecting the Embryonic and Fetal Periods;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Washington

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: AMERICAN UNIVERSITY

ORG_STATE: DC

PHR: Narrative Relevance to Public Health Obesity rates in the United States are among the highest in the world, leading to increased risk for illness and chronic disease. Maternal stress is associated with children’s increased risk for obesity, with the strongest association seen in Latino families, yet existing programming has failed to address this risk factor. The proposed research seeks to evaluate the feasibility of a mindful parenting intervention designed to reduce maternal stress and improve mothers’ eating and weight-related behaviors in families whose children are at highest risk for obesity.

PI_NAMEs: COTTER, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: acceptability and feasibility;active control;Address;adherence rate;Age;Area;arm;Award;Awareness;base;Behavior;Body mass index;Caucasians;Child;Child Health;Child Nutrition;Child Rearing;Chronic Disease;Communities;Conduct Clinical Trials;Data;Decision Making;Development;disparity reduction;Eating;efficacy trial;elementary school;emotional distress;Environment;Evaluation;Exercise;exercise intervention;exercise program;experience;Family;feasibility testing;Feedback;Focus Groups;Food Packaging;Goals;Health;Health Care Costs;high risk;Household;implementation evaluation;improved;Individual;innovation;Integrative Therapy;interest;Intervention;Interview;K-Series Research Career Programs;Latina;Latino;Latino Population;Life;Longitudinal Studies;Manuals;marginalized population;maternal stress;Measures;Mediating;Mentored Patient-Oriented Research Career Development Award;Mentors;mindfulness;mindfulness intervention;Mindfulness Training;mindfulness-based stress reduction;Morbidity - disease rate;mortality;Mothers;multidisciplinary;Not Hispanic or Latino;nutrition;Nutritional;Obesity;obesity in children;obesity prevention;obesity risk;Outcome;parenting intervention;Parents;Participant;Patient Recruitments;Phase;Physical activity;Physiological;pilot test;Population;Preparation;Prevalence;Prevention program;Prevention Research;Program Acceptability;programs;psychologic;Psychological Stress;Public Health;Quality of life;randomized, clinical trials;recruit;Reduce health disparities;Reporting;Research;Research Activity;research and development;Research Personnel;response;retention rate;Risk;Risk Factors;Risk Reduction;satisfaction;School-Age Population;Shapes;skill acquisition;skills;Socioeconomic Status;Spanish;standard of care;Statistical Methods;statistics;Stress;stress reduction;Stressful Event;stressor;Structure;theories;therapy design;therapy development;Training;Training Activity;Translating;trial comparing;trial design;Underserved Population;United States;Weight

PROJECT_TITLE: Reducing Maternal Stress to Improve Obesity-related Parenting Practices


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: 8. PROJECT NARRATIVE People who inject drugs and live in rural areas are at risk for HIV, often confront stigma, and have limited access to services they need. We propose to evaluate an intervention in which peer-educators disseminate health information and HIV self-test kits to members of their social networks. Treatment linkages will be directed through local syringe exchange programs and will be supported by telemedicine services.

PI_NAMEs: FALADE-NWULIA, OLUWASEUN  (contact);LUCAS, GREGORY M

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: addiction;Adoption;Africa South of the Sahara;AIDS prevention;antiretroviral therapy;attentional control;Awareness;Biological Testing;Caring;Communication;Communities;community engaged approach;community organizations;comparison control;comparison intervention;Data;Diagnostic Reagent Kits;Effectiveness;effectiveness evaluation;effectiveness/implementation hybrid;empowerment;evidence base;Evidence based intervention;experience;Face;FDA approved;Food;Goals;Health;Health Services Accessibility;Hepatitis C Therapy;High Prevalence;HIV;HIV diagnosis;HIV risk;HIV/HCV;Housing;Human immunodeficiency virus test;implementation measures;implementation outcomes;implementation process;improved;indexing;Individual;Information Dissemination;Injecting drug user;innovation;Intervention;Knowledge;marginalized population;Mediator;Medical;medication for opioid use disorder;member;men who have sex with men;Methods;Modeling;Modification;Needle-Exchange Programs;Network-based;Outcome;pandemic disease;Participant;Patient Self-Report;peer;Pharmaceutical Preparations;Population;pragmatic trial;pre-exposure prophylaxis;prevention service;primary outcome;programs;Provider;Public Health;Questionnaires;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Resources;Risk;Risk Reduction;Rural;rural area;scale up;Self Efficacy;self testing;service programs;Service provision;service uptake;Services;skills training;social influence;Social Network;social network intervention;social stigma;Specialist;Structure;Surveys;telehealth;Telemedicine;Testing;Training;treatment services;trial design;Trust;uptake;virtual;Work;World Health Organization

PROJECT_TITLE: Implementation of telemedicine and social network driven HIV service uptake for comprehensive HIV service integration in rural syringe service programs


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Influenza;Machine Learning and Artificial Intelligence;Pneumonia and Influenza;Precision Medicine;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative I propose to develop and use a novel framework to integrate host genetic data with three-dimensional structurally-resolved host-pathogen protein networks to uncover immuno-modulatory molecular phenotypes in infectious disease. The incorporation of structural information provides a significant refinement over the traditional principle of “guilt-by-association”, and allows us to hone in on specific molecular phenotypes that modulate infectious disease risk. While the focus of the proposal is to use this approach to infectious diseases, the framework itself is generalizable and can be used across other immunological disease contexts.

PI_NAMEs: DAS, JISHNU  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: 3-Dimensional;Anti-viral Response;Automobile Driving;Biological Markers;Communicable Diseases;comparative;Data;Data Set;Databases;Disease;Disease Progression;disorder risk;experience;flu;frontier;Functional disorder;Generations;Genetic;Genetic Diseases;genetic variant;Genetic Variation;genomic data;genomic locus;genomic variation;Genomics;Goals;Guilt;HIV;HIV risk;Homology Modeling;Human;Human Genetics;Immune system;Immune System Diseases;Immunity;immunoregulation;Individual;Influenza;innovation;Intervention;Machine Learning;Malaria;Maps;Mediating;Mendelian disorder;Modernization;Molecular;molecular phenotype;Molecular Profiling;Mutation;novel;pathogen;Pathway Analysis;Penetrance;Phenotype;Population Genetics;predictive marker;protein data bank;Proteins;Resolution;Role;Sensitivity and Specificity;System;Systems Biology;Technology;therapy design;three dimensional structure;Tuberculosis;two-dimensional;Vaccines;Validation;Variant;Viral Proteins;Work

PROJECT_TITLE: Using three-dimensional protein networks to uncover immuno-modulatory molecular phenotypes in infectious disease


PHR: PROJECT NARRATIVE Home infusion therapy, in which patients and informal caregivers perform central venous catheter maintenance, is a rapidly-growing area of healthcare, and central line-associated bloodstream infections (CLABSI) in this setting are an under-recognized concern that requires improved surveillance and prevention strategies. We propose to work with a collaboration of five home infusion agencies to validate and benchmark a candidate home infusion CLABSI surveillance definition, and to implement a healthcare worker and patient and caregiver-directed CLABSI prevention bundle.

PI_NAMEs: KELLER, SARA CONDRON (contact)

PROGRAM_OFFICER_NAME: HENDERSON, SUSAN

PROJECT_TITLE: The Home Infusion Collaborative to Eliminate Central Line-Associated Bloodstream Infections (CLABSI)


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Millions of children are hospitalized every year and many will experience unintended harm caused by a breakdown in communication between the multiple clinicians caring for them. This Pediatric Patient Safety Learning Laboratory will develop interventions that help clinicians, such as nurses and doctors, communicate more effectively. The findings from our Learning Laboratory will be relevant to all hospitalized children because communication between clinical teams is essential for safe, effective, and high quality care.

PI_NAMEs: RUPPEL, HALLEY  (contact)

PROJECT_TITLE: Resilient Communication Systems: A Pediatric Patient Safety Learning Lab


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as it will bring cancer clinical trials and cancer care delivery research to minority and underserved individuals in their own communities. The inclusion of these individuals in the research will both broaden the applicability of the science and help to reduce health care disparities experienced by minority and underserved cancer patients.

PI_NAMEs: BEAR, HARRY D;MATIN, KHALID  (contact);SHEPPARD, VANESSA B

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Address;Adult;African American population;American College of Radiology Imaging Network;Ancillary Study;anti-cancer research;Area;Award;base;biobank;cancer care;Cancer Center;cancer clinical trial;Cancer Control;Cancer Control Research;cancer health disparity;Cancer Patient;cancer prevention;cancer therapy;care delivery;Caring;Catchment Area;Childhood;Clinical;Clinical Research;Clinical Treatment;clinical trial enrollment;Clinical Trials;clinically significant;Collaborations;Collection;Colorectal Cancer;Communities;Community Clinical Oncology Program;community collaboration;Community Practice;Death Rate;demographics;Detection;Development;Disparity;Eastern Cooperative Oncology Group;Educational Status;Enrollment;ethnic disparity;ethnic minority;Ethnic Population;experience;Feedback;Funding;Geography;Goals;Gynecologic;health care disparity;Health Personnel;Human Resources;Image;improved;Incidence;Individual;insight;interest;Lead;Low income;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;Measures;Medical Oncologist;medically underserved;member;Minority;Minority Enrollment;Minority Groups;Minority-Based Community Clinical Oncology Program;Mission;mortality;Oncologist;Oncology;Outcome;outreach;Participant;Patients;Pediatric Oncology Group;Personal Satisfaction;Phase;Population;Prevention;Prevention Research;Primary Health Care;Prognosis;programs;protocol development;Protocols documentation;Public Health;Quality of life;racial disparity;racial minority;racial population;Radiation Oncologist;Recording of previous events;Research;Research Personnel;research study;Resources;Rural;rural African American;Rural Community;rural patients;Rural Population;Science;screening;Site;socioeconomic disparity;Socioeconomic Factors;Specialist;Surgeon;treatment research;treatment trial;underserved community;underserved minority;Underserved Population;Universities;Urban Population;Virginia

PROJECT_TITLE: VCU Massey Cancer Center Minority/Underserved NCI Community Oncology Research Program