NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Infectious Diseases;Kidney Disease;Liver Disease;Organ Transplantation;Patient Safety;Transplantation

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Public Health Relevance Safely expanding the donor pool for solid organ transplantation, and optimally matching donors to the right recipient, is one of the most critical concerns for patients, transplant physicians, and referring nephrologists and hepatologists. This award will allow Dorry Segev, MD, PhD and his team of mentees to better guide clinical decision-making and policy in transplantation, particularly in the context of novel expansions such as HIV-infected donors and recipients, expanded criteria for living donation, and immunological incompatibility. It will also support Dr. Segev's training of new investigators to study ways to improve the health of transplant patients through rigorous patient-oriented research.

PI_NAMEs: SEGEV, DORRY L. (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Ancillary Study;Antibodies;Area;Atmosphere;Award;Biological Markers;career;clinical decision-making;Clinical Research;Clinical Trials;cohort;Cohort Studies;Communication;Country;Data;Data Linkages;data registry;design;Doctor of Philosophy;Donor person;Educational Curriculum;Educational process of instructing;Environment;Epidemiologist;Evaluation;evidence base;Faculty;fatty liver disease;Fellowship;First Name;Foundations;frailty;Funding;Genetic;Goals;graduate student;Grant;Health;health literacy;HIV;Immunologics;Impaired cognition;improved;Individual;Infrastructure;Insurance;K-Series Research Career Programs;Kidney;Kidney Diseases;Kidney Transplantation;Leadership;Learning;Liver;Liver Fibrosis;liver transplantation;Living Donors;living kidney donor;Longitudinal Studies;Measurement;Medical Students;Mentors;Mentorship;Methodology;Modality;Modeling;mortality;Multicenter Studies;multidisciplinary;next generation;novel;Operative Surgical Procedures;Organ;organ transplant recipient;Organ Transplantation;Outcome;Paper;patient oriented research;Patients;Pharmaceutical Preparations;Pharmacy facility;Physicians;Policies;Population;Positioning Attribute;post-transplant;Process;Productivity;prospective;Provider;public health relevance;Publishing;Research;Research Personnel;Risk Marker;Scientist;Solid;Structure;superinfection;Surgeon;System;Time;tool;Training;Transplant Recipients;Transplant Surgeon;Transplantation;Transplantation Surgery;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Universities;Waiting Lists;Writing

PROJECT_TITLE: Patient Oriented Research in Solid Organ Transplantation

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: DE

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Craniofacial congenital anomalies are amongst the most common birth defects, but current treatments remain limited to surgical correction; this is in part due to a lack of understanding of the way cells move to give rise to craniofacial structures and how these behaviors are controlled. We have established new approaches that allow us to observe cell behaviors during craniofacial morphogenesis in mouse embryos. These techniques give us an unprecedented view of craniofacial morphogenesis, which ultimately may lead us to discover new approaches to treating these common conditions.

PI_NAMEs: BUSH, JEFFREY OHMANN (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Address;Automobile Driving;Behavior;cell behavior;cell motility;Cell Physiology;Cell Separation;Cells;Choristoma;Collaborations;Congenital Abnormality;congenital anomaly;craniofacial;Craniofacial Abnormalities;craniofacial development;craniofacial structure;craniofacial tissue;craniofrontonasal syndrome;CRISPR/Cas technology;Disease;Dysmorphology;Embryo;Epithelium;gene regulatory network;Goals;Human;human induced pluripotent stem cells;imaging platform;Knowledge;Laboratories;Learning;Lip structure;Mesenchymal;Methodology;Modeling;Molecular;Morphogenesis;Mus;Mutagenesis;novel;novel strategies;Operative Surgical Procedures;Pattern;physical process;Process;Resolution;Secondary Palate;Series;Shapes;Signal Transduction;System;Techniques;Therapeutic;Time;Tissue Engineering;Tissues;tool

PROJECT_TITLE: Signaling control and cellular basis of craniofacial morphogenesis and congenital disease


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Lung;Lung Cancer;Lymphatic Research;Orphan Drug;Precision Medicine;Prevention;Radiation Oncology;Rare Diseases;Uterine Cancer;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative SCC is the only NCI-designated Comprehensive Cancer Center in Missouri and Southern Illinois and it is the leading oncology treatment facility within the St. Louis metropolitan area. Participation in the NCTN allows WU/SCC physicians to offer a broad range of clinical trials to patients with all types and stages of cancer and also provides an opportunity for investigators to confirm preliminary institutional findings regarding new cancer treatments, diagnostic tools, and prognostic markers in large numbers of patients.

PI_NAMEs: BARTLETT, NANCY L (contact);KOZOWER, BENJAMIN D;ROBINSON, CLIFFORD GRANT;SIEGEL, BARRY A.;THAKER, PREMAL HARISH

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Acute leukemia;Address;American College of Radiology Imaging Network;anti-cancer research;Area;base;biobank;Cancer Center;Cancer Control;cancer therapy;Clinical Research;Clinical Trials;Collaborations;Communication;Comprehensive Cancer Center;control trial;Cooperative Group Program;Correlative Study;Data;design;Development;diagnostic tool;Disease;Eastern Cooperative Oncology Group;experience;Faculty;Fostering;Genomics;Goals;Gynecologic Oncology;Illinois;Image;imaging program;imaging study;improved;Institution;Investments;Lead;Leadership;Lymphoma;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Medical Oncology;member;Mentors;Mentorship;metropolitan;mid-career faculty;Mission;Missouri;Modality;Molecular;molecular imaging;novel;Oncology;operation;Pathology;Patients;Physicians;Play;Positioning Attribute;predictive marker;Principal Investigator;professor;Prognostic Marker;programs;proteogenomics;Protocols documentation;Quality of life;Radiation Oncology;Radiology Specialty;rare cancer;Recording of previous events;Rectal Cancer;Reporting;Research Personnel;Resistance;response;Sarcoma;Site;Specialist;Therapeutic;Therapeutic Trials;Thoracic Oncology;Translational Research;translational scientist;Universities;Uterine Cancer;Washington

PROJECT_TITLE: Washington University/Siteman Cancer Center Lead Academic Site


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Radiation Oncology;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE  Radiation is a cornerstone treatment for glioblastoma but tumors inevitably recur due to radiation resistance. We have found that abnormal purine metabolism is a key mediator of this resistance. This research proposal will define how radiation and purine metabolism regulate one another and whether inhibitors of purine metabolism could be combined with radiation to treat patients with glioblastoma.

PI_NAMEs: WAHL, DANIEL R (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Acute;Affect;Biological Assay;Brain Neoplasms;Cells;chemotherapy;Clinical;Clinical Trials;Combined Modality Therapy;Communication;Data;Development;DNA Damage;DNA Repair;DNA-dependent protein kinase;Dose;ds-DNA;efficacy evaluation;Excision;Exhibits;experimental study;FDA approved;FRAP1 gene;genetic approach;Glioblastoma;Goals;Guanosine Triphosphate;guanylate;improved;in vitro Model;in vivo;Individual;inhibitor;Interruption;Invaded;Link;Malignant Neoplasms;Mass Spectrum Analysis;Maximum Tolerated Dose;Measures;Mediating;Mediator;Metabolic;metabolic phenotype;metabolomics;Methodology;Modeling;Molecular;Mus;mycophenolate mofetil;Nature;neurosarcoidosis;Neurosphere;Nonhomologous DNA End Joining;nucleotide analog;nucleotide metabolism;Nucleotides;Operative Surgical Procedures;Pathway interactions;patient derived xenograft model;Patient Selection;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Phase I Clinical Trials;phosphoproteomics;Pre-Clinical Model;predicting response;Primary Brain Neoplasms;Proliferating;Proto-Oncogene Proteins c-akt;Purine Antagonist;purine metabolism;Purines;Pyrimidines;rac1 GTP-Binding Protein;Radiation;Radiation Dose Unit;radiation effect;Radiation Induced DNA Damage;radiation resistance;radiation response;radioresistant;randomized trial;Recurrence;Regulation;repaired;Reporter;Research;Research Proposals;Resistance;response;Safety;Signal Transduction;Signaling Molecule;stable isotope;Supplementation;Testing;Therapeutic;Tissues;Tracer;tumor;Tumor Tissue;Work;Writing

PROJECT_TITLE: Targeting Nucleotide Metabolism to Overcome Therapy Resistance in Glioblastoma

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Cancer;Chronic Pain;Immunotherapy;Lung;Lung Cancer;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Nerves are found in many types of solid tumors; however, tumor innervation has long been viewed as passive bystanders in cancer. Although increased innervation is associated with aggressive tumor phenotype and poor prognosis in cancer patients, the underlying biology of these clinical associations has been elusive. Our research aims to develop an in-depth and broad understanding of neuro-immune interactions in cancer with a particular focus on the bi-directional crosstalk between the nociceptive sensory neurons and the tumor microenvironment (TME), and to explore whether we can target such interactions for more effective cancer treatment.

PI_NAMEs: JIN, CHENGCHENG  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Ablation;Afferent Neurons;anti-PD-1;Automobile Driving;Bacterial Infections;Biology;Calcium;cancer cell;cancer genetics;cancer initiation;Cancer Patient;cancer prevention;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;Cells;Cellular Immunology;cellular targeting;Clinical;Communication;Coughing;cytotoxic CD8 T cells;Development;Foundations;Future;Genetic;Genetically Engineered Mouse;Goals;Human;Hypersensitivity;IL17 gene;Image;Immune;immune checkpoint blockade;Immune response;Immune system;Immunofluorescence Immunologic;Immunotherapy;improved;in vitro Assay;in vivo;Inflammation;insight;interest;Investigation;Light;Literature;Lung;Lung Adenocarcinoma;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Nerve;nerve supply;Nervous System;neural;Neural Pathways;Neurites;Neuroimmune;neuronal circuitry;Neurons;Neuropeptides;neutrophil;Neutrophil Infiltration;new therapeutic target;Nociception;Nociceptors;Pain;Peripheral Nerves;pharmacologic;Phenotype;Play;preclinical efficacy;Prognosis;Publishing;Research;Resistance;response;Role;Sensory;sensory mechanism;Shapes;Signal Transduction;Skin;Solid Neoplasm;Stimulus;Symptoms;T-Lymphocyte;Technology;Testing;Time;Tissues;tool;TRPV1 gene;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-Derived;tumor-immune system interactions;tumorigenesis;Work

PROJECT_TITLE: Investigating the neutrophil-sensory neuron crosstalk in lung cancer

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: BALTIMORE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The research proposed in this application will investigate and target the aberrant TLR4-MyD88 signaling pathways that regulate disease promoting macrophages (immune cells) associated with laryngotracheal stenosis. Secondarily, we will investigate the utility of the S100A8/A9 protein as a predictor for the development of laryngotracheal stenosis in patients who require prolonged endotracheal intubation for critical illness.

PI_NAMEs: MOTZ, KEVIN  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Adult;Attenuated;Automobile Driving;Biological Response Modifiers;biomarker development;Biopsy;Bypass;candidate marker;career;CD4 Positive T Lymphocytes;Cells;Collagen;Communication impairment;Critical Illness;Critical Pathways;cytokine;Data;Development;Disease;Dysphonia;Dyspnea;Excision;experience;Experimental Designs;Fibrosis;Flow Cytometry;Foundations;Gene Expression;genetic regulatory protein;Goals;Histologic;Human;Iatrogenesis;Immune;Immune response;Immune Targeting;Immunology;Immunophenotyping;improved;Inflammation;Inflammatory Infiltrate;Injury;Interleukin-1 beta;Intervention;Intratracheal Intubation;Intubation;Investigation;Knowledge;Laboratories;Lamina Propria;Laryngeal Diseases;Larynx;Lead;Life;Macrophage;Macrophage Activation;Mediating;Medical;Mentors;Modeling;Molecular;mouse model;Mucous Membrane;Mus;Operative Surgical Procedures;pathogen;Pathogenesis;Pathologic;Pathway interactions;Patients;Pattern;Phenotype;Physiological;Population;prevent;protein expression;Proteins;receptor;Regulatory Pathway;Research;Research Training;Resected;Role;S100A8 gene;Secondary to;Serum;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skills;Source;Stenosis;Subglottis structure;targeted treatment;Therapeutic Intervention;Tissues;TLR4 gene;Toll-like receptors;Trachea;Tracheostomy procedure;Transgenic Organisms;treatment strategy;wound healing

PROJECT_TITLE: Targeting pathologic macrophage activation through inhibition of MyD88 to attenuate laryngotracheal stenosis

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Alveolar bone defects are one of the most clinically relevant situations in patients with periodontal disease and trauma. The objective is to develop and validate if injectable highly porous nanofiber microspheres in combination with biomimetic delivery of signaling molecules and/or stem cells can greatly promote alveolar bone regeneration after minimally invasive administration to critical-sized alveolar bone defects.

PI_NAMEs: XIE, JINGWEI  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Acceleration;aged;alveolar bone;angiogenesis;Binding;Binding Proteins;Biological;Biomimetics;BMP2 gene;BMP5 gene;bone;Bone Diseases;bone healing;bone loss;bone marrow mesenchymal stem cell;bone mass;bone prosthesis;Bone Regeneration;Bone Resorption;Bone Transplantation;Cell Fate Control;Cells;clinically relevant;cost;Coupled;Coupling;Data;Defect;Dental Implants;Development;Endothelial Cells;Engineering;Engraftment;fabrication;Foundations;Gases;healing;Human;Immobilization;Implantation procedure;Injectable;Injections;Mandible;Maxilla;Methods;Microspheres;mineralization;Minerals;minimally invasive;Modeling;Molar tooth;Morphology;nanofiber;Natural regeneration;Operative Surgical Procedures;Osteogenesis;osteogenic;Patients;Peptides;peptidomimetics;Periodontal Diseases;Play;Porosity;Proliferating;Proteins;Rattus;receptor;Receptor Cell;recombinant human bone morphogenetic protein-2;regenerative;Regenerative capacity;regenerative therapy;repaired;response;Risk;Role;side effect;Signaling Molecule;Site;stem cells;Structure;Surface;Surgical Flaps;Suspensions;Swelling;Techniques;technology platform;Testing;Therapeutic;Tissues;Tooth Extraction;Tooth Tissue;Trauma;Tubular formation;Umbilical vein;Vascular Endothelial Growth Factors;Vascularization

PROJECT_TITLE: Biomimetic and Injectable Highly Porous Nanofiber Microsphere-based Platform for Alveolar Bone Regeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Training the next generation of chemosensory scientists is essential for developing new treatments for chemosensory dysfunction, promoting better eating habits, enhancing quality of life, and even diminishing disease transmission by vector insects and parasites. The impact of chemosensory dysfunction alone is highly significant, particularly in the age of COVID-19: it is estimated that 10% of people exhibit smell or taste impairments, negatively influencing their diet, danger avoidance, interpersonal relationships and quality of life.

PI_NAMEs: WESSON, DANIEL W (contact)

PROJECT_TERMS: Science;Sensory;Training Programs

PROJECT_TITLE: Training Program in Chemosensory Science


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Stressful life events significantly degrade qualify of life and mental health in some individuals, but other individuals seem resilient to its effects. We still don’t have a satisfactory understanding of the differences in the brains of those individuals who are impacted by stress and those who are not. This proposal seeks to study the activity between two brain regions that are important in arousal to understand how their activity can drive some individuals to be more vulnerable to the effects of stress.

PI_NAMEs: BHATNAGAR, SEEMA  (contact);CHUNG, SHINJAE

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Anesthesia procedures;Animals;Area;Arousal;Attention;Behavior;Behavioral;biological adaptation to stress;Brain;Brain region;Cell Nucleus;cell type;Cells;Cognitive;comparison control;Control Animal;Data;Development;Disinhibition;Ensure;Exhibits;experimental study;Exposure to;Female;Fiber;flexibility;Genetic;Grooming;Individual;Individual Differences;individual variation;insight;Lead;locus ceruleus structure;male;Mediating;Mental Health;Modeling;motivated behavior;Motivation;mouse model;Mus;Negative Valence;Neurons;Norepinephrine;Outcome;Phenotype;Photometry;Play;Pontine structure;Positive Valence;Predisposition;Psychopathology;Publishing;Quality of life;Rattus;receptor;Recovery;Research;Research Domain Criteria;Research Personnel;resilience;response;Role;sensor;Sex Differences;social;social defeat;social stress;social stressor;Source;Specificity;Stress;Stressful Event;stressor;Structure;Structure of paraventricular nucleus of thalamus;System;Techniques;Testing;Thalamic structure;tool;women versus men;Work

PROJECT_TITLE: Role of locus coeruleus-paraventricular thalamic projections in social threat processing

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative  The proposed research examines to what extent the observed quality of childhood and adolescent experiences with maternal and paternal caregivers shape young adults’ basic expectations about the degree to which significant others are likely to be available, responsive, and helpful under challenging circumstances and, in turn, to what extent those expectancies among adults predict both: (a) mental and physical health and (b) interpersonal adjustment in adulthood, as reflected in the quality of adults’ romantic relationships as well as their infants’ attachments in the next generation. There is increasing evidence that these expectations—which are reflected in variation in secure base script knowledge—represent fundamental psychological resources that support healthy adult interpersonal relationships along with mental and physical health in the years of maturity. Our proposal seeks to provide more definitive, large sample evidence regarding the origins of secure base script knowledge in interpersonal experiences with primary caregivers from infancy through late adolescence, along with precise estimates of the transmission of such expectancies from parents to their children across risk status, participant sex, and two racial groups (White/non-Hispanic and Black), Aims fundamental to the goals of NIH generally and the EKS NICHD in particular. 1

PI_NAMEs: ROISMAN, GLENN I (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 18 year old;Address;Adolescence;Adolescent;Adult;Area;Autobiography;base;Black race;Caregivers;caregiving;Caring;Child;Child Care;Child Rearing;Childhood;Code;Cognitive;Collaborations;Communication;Data;Data Analyses;data de-identification;data resource;Data Set;Databases;Development;Emotional;Event;Expectancy;expectation;experience;Family;Goals;Grant;high risk;improved;Individual;Individual Differences;infancy;Infant;innovation;insight;intergenerational;Interpersonal Relations;Interview;Knowledge;Language;Longitudinal Studies;Mediating;Memory;Mental Health;mental representation;Meta-Analysis;Methods;Minnesota;National Institute of Child Health and Human Development;next generation;Not Hispanic or Latino;Outcome;Parents;Participant;Pathway Analysis;physical conditioning;Poverty;primary caregiver;Protocols documentation;psychologic;Race;racial population;Research;Resources;Risk;Role;Sample Size;Sampling;Science;Scoring Method;Secure;Security;sex;Shapes;Structure;theories;tool;Training;Transcript;transmission process;United States National Institutes of Health;Variant;Water;young adult

PROJECT_TITLE: Secure Base Script Knowledge: Antecedents and Sequelae

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Rehabilitation;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: PROJECT NARRATIVE The ultimate goal of the proposed study is to establish an interdisciplinary speech intervention model for speakers with communication disorders who cannot receive speech therapy in English in the United States. As a first step, the proposed project aims to develop and conduct a small-scale clinical trial study in which the linguistic and cultural diversity of the participants (Korea-born immigrants with Parkinson’s disease) is taken into account. In recognition of the family-centered decision making (FCDM) among East Asian health service users, families of PD participants will be also regarded as active participants of the intervention program with respect to their communication skills with PD patients and health/well-being.

PI_NAMEs: KIM, YUNJUNG  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Address;Adult;Aftercare;Aging;Attention;bilingualism;Censuses;Classification;Clinical;clinical practice;Clinical Trials;Communication;Communication impairment;Communities;Counseling;Cultural Diversity;Decision Making;disability;Disease;Distress;Dysarthria;East Asian;Environmental Risk Factor;Ethics;ethnic diversity;Ethnic Origin;Exclusion;Family;follow-up;Generations;Goals;Group Therapy;Health;health care availability;health care disparity;health care quality;health literacy;Health Personnel;Health Services;Heterogeneity;Hour;human old age (65+);Immigrant;improved;innovation;International;Intervention;intervention effect;intervention participants;intervention program;Korea;Koreans;Language;Linguistics;Literature;Measures;Medical;Methodology;Minor;Minority;Modeling;Morals;Multilingualism;Multiple Sclerosis;neurological rehabilitation;Outcome Measure;Parkinson Disease;Participant;Patients;Personal Satisfaction;Persons;Physical therapy;poor health outcome;Population;Population Projection;primary outcome;programs;Quality of life;racial diversity;rehabilitation service;Rehabilitation therapy;Reporting;Research;Role;secondary outcome;Services;skills;Social Distance;Speech;Speech Acoustics;Speech Intelligibility;Speech Therapy;Techniques;telehealth;Time;Training;treatment program;United States;Voice

PROJECT_TITLE: Toward a speech rehabilitation model for linguistically and culturally minor groups: Foreign born immigrants

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Mental Health;Mental Illness;Neurodegenerative;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE/RELEVACE TO PUBLIC HEALTH This project investigates neuromodulation of emotional responses using intercranial depth electrodes and the relationship between anxiety symptoms and these responses in treatment resistant epilepsies (TRE). This research is expected to identify brain areas that mediate emotion network dysfunction, leading to anxious symptom experience. The research project will identify potential treatment targets for anxiety and epilepsy disorders and provide data for a subsequent R01 clinical trial proposal.

PI_NAMEs: GOODMAN, ADAM M (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Alabama;Amygdaloid structure;Anxiety;Anxiety Disorders;anxiety symptoms;Area;Behavior;behavior measurement;Behavioral;behavioral response;Brain;brain behavior;Clinical Research;Clinical Trials;Cognition;Cognitive;comorbidity;conditioned fear;conditioning;Cues;Data;Disease;Electric Stimulation;Electrodes;Electroencephalography;emotion regulation;Emotional;Emotions;Epilepsy;Equipment and supply inventories;Evaluation;expectation;experience;experimental study;Functional disorder;Functional Magnetic Resonance Imaging;Future;Galvanic Skin Response;Goals;High Prevalence;Human;Implant;Individual;information processing;Investigation;Knowledge;Laboratories;Learning;Link;Measurement;Measures;Mediating;Memory;Mental Depression;Mental Health;Modeling;Moods;network dysfunction;neural;neural circuit;neurobehavioral;Neurobiology;neuroregulation;novel;Operative Surgical Procedures;Patients;perceived stress;Persons;Pharmaceutical Preparations;Physiologic pulse;Physiological;power analysis;Prefrontal Cortex;Prevalence;Process;Public Health;randomized, clinical trials;Regulation;Research;Research Personnel;Research Project Grants;Resistance;Resources;response;Seizures;Severities;Stimulus;success;Symptoms;Techniques;Testing;therapy development;tool;Training;trait;treatment center;treatment trial;Universities;Work

PROJECT_TITLE: Stimulation-induced modulation of fronto-limbic responses to threat

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_CITY: AUGUSTA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Non-steroidal anti-inflammatory drugs (NSAIDs) such as sulindac can exert immunopotentiating effect by inhibiting the activities of cyclooxygenases (COX). However, long-term inhibition of COX can cause severe toxicities in some vital organs. This project will develop novel non-COX inhibitory sulindac derivatives and employ them as immunomodulators to augment the efficacy of cancer immunotherapies by targeting specific phosphodiesterase (PDE).

PI_NAMEs: PIAZZA, GARY A;ZHOU, GANG  (contact)

PROGRAM_OFFICER_NAME: YOVANDICH, JASON L

PROJECT_TERMS: Adverse effects;anti-tumor immune response;anticancer activity;Antineoplastic Agents;beta catenin;Binding;Biological;cancer cell;cancer chemoprevention;cancer immunotherapy;cancer infiltrating T cells;cancer therapy;CAR T cell therapy;carcinogenesis;CD19 gene;celecoxib;cell growth;chemical synthesis;Chemicals;Chemopreventive Agent;chimeric antigen receptor;Cialis;Colonic Neoplasms;Colorectal Cancer;Complex;Coxibs;Cyclic GMP;cyclooxygenase 1;cyclooxygenase 2;Cyclooxygenase Inhibitors;Data;Dendritic Cells;design;Development;Disease;drug candidate;drug development;effectiveness testing;endoplasmic reticulum stress;engineered T cells;epidemiology study;Fever;Genetic Transcription;Growth;Human;Ibuprofen;Immune;immune activation;immunogenic;immunogenic cell death;Immunologic Surveillance;Immunomodulators;Immunopotentiation Effect;immunoregulation;Immunosuppression;improved;In Vitro;in vivo;Incidence;Individual;Indomethacin;Induction of Apoptosis;Inflammation;inhibitor;Isoenzymes;knock-down;Knowledge;Laboratories;Lead;Lymphoma cell;Malignant - descriptor;Malignant Neoplasms;Mediating;migration;Modeling;Modification;Molecular;mouse model;Mus;neoplastic cell;Non-Steroidal Anti-Inflammatory Agents;novel;Oncogenic;Oral Administration;Organ;overexpression;pain relief;PD-1 blockade;Pharmacotherapy;phosphoric diester hydrolase;Pre-Clinical Model;programs;Property;Prostaglandin-Endoperoxide Synthase;Prostaglandins;prototype;Regulatory T-Lymphocyte;Reporting;Research;Rodent Model;screening;Series;Signal Transduction;Small Interfering RNA;stem cell function;Sulfones;Sulindac;Synthesis Chemistry;T cell therapy;T-Lymphocyte;Testing;Toxic effect;tumor;Tumor Immunity;tumor microenvironment;tumorigenesis

PROJECT_TITLE: Exploiting the immunomodulatory effects of sulindac and novel non-COX inhibitory derivatives for cancer treatment

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: Nashville

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Using rigorous quasi-experimental methods with a high-quality, longitudinal, linked health and education dataset on Tennessee children with a Medicaid record, we will generate timely, generalizable knowledge on the implementation and impact of school-based health centers (SBHCs) and policy and program levers that can be employed to increase their efficacy in improving child mental health and education outcomes. We will advance our understanding of the mechanisms by which SBHCs may improve children’s outcomes by elaborating and testing a child-centered conceptual framework for examining in-depth the organization and implementation of SBHCs and comprehensively documenting the operations and services of different SBHC types (traditional on-campus, school-linked, mobile, and telehealth) and the extent to which they are effectively serving disadvantaged or underserved subgroups of children, including in rural areas.

PI_NAMEs: BUNTIN, MELINDA J;HEINRICH, CAROLYN  (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: access disparities;Address;Adolescent;Affect;Affordable Care Act;Area;behavioral health;Black Box;Child;Child Health;Child Mental Health;child mental health service;child poverty;children of color;Communities;coping;COVID-19 pandemic;Data;Data Reporting;Data Set;Dimensions;Disadvantaged;Documentation;Economics;Education;educational atmosphere;Effectiveness;Equity;Evaluation;Face;Family;Funding;Health;health care availability;health care service;Health Personnel;Health Services;Health Services Accessibility;Healthcare Systems;Home;Immigrant;improved;Inequity;innovation;Institution;Institutional Racism;Interview;Knowledge;Link;long-standing disparities;Low income;marginalization;Medicaid;Medical;Mental Health;Mental Health Services;Methods;mHealth;Modeling;Mothers;multidisciplinary;neglect;operation;Outcome;pandemic disease;pandemic disruption;Partnership Practice;Personal Satisfaction;Policies;Population;prevent;Professional counselor;Program Development;programs;Quasi-experiment;racial disparity;racial population;Research;Research Methodology;Resources;Risk;Role;rural area;school based health center;School Enrollments;School-Age Population;Schools;service delivery;Services;Site Visit;Social isolation;Social support;Stress;stressor;Students;Subgroup;Supervision;Surgeon;Surveys;telehealth;Tennessee;Testing;theories;Time;tool;Trauma;underserved community;Youth

PROJECT_TITLE: A Multidisciplinary, Mixed Methods Analysis of the Implementation and Efficacy of School-Based Health Centers and Mechanisms through which SBHCs Improve Child Mental Health and Education Outcomes

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE This Interdisciplinary Training Program in Auditory Neuroscience (TPAN) will provide graduate student training, research experience, and a vibrant community at the interface of neuroscience and neurotechnology, in both human and animal models. This training program will prepare students for independent research careers that can improve our understanding of auditory system function and treatments of auditory system dysfunction using innovative tools and technologies. It is expected that graduates of this training program will develop creative solutions, devices and strategies to advance sensory neuroscience and to ultimately assist and prevent hearing loss in human patients.

PI_NAMEs: BARTLETT, EDWARD ;HEINZ, MICHAEL G (contact)

PROJECT_TERMS: Auditory;Neurosciences;Training

PROJECT_TITLE: Interdisciplinary Training in Auditory Neuroscience


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Orphan Drug;Prevention;Rare Diseases

ORG_DEPT: PATHOLOGY

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: PROJECT NARRATIVE Head and neck cancer is the sixth most prevalent cancer in the world and treatment efficiency is still limited. Therefore, a therapy that can effectively control growth and prevent this disease with minimal off-target side effects is highly desirable. We anticipate our results will identify the efficacy of momordicine-I along with additional chemotherapies in controlling tumor growth in preclinical models and will help in driving therapeutic development.

PI_NAMEs: RAY, RATNA B. (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Address;Aftercare;Animal Cancer Model;Animal Model;anti-PD1 antibodies;Apoptotic;Automobile Driving;Biochemical;Carcinogens;Cell Physiology;Cells;Cessation of life;chemotherapy;Cisplatin;Data;Disease;efficacy evaluation;Epithelium;Etiology;feeding;Funding;Future;Global Change;Glucose;glucose metabolism;Grant;Growth;Head and Neck Cancer;head and neck cancer patient;head and neck cancer prevention;Head and Neck Neoplasms;Heavy Drinking;Human papilloma virus infection;Immune;Immunocompetent;immunoregulation;Immunosuppression;improved;innovation;Knowledge;lipid metabolism;Lipids;malignant mouth neoplasm;Malignant Neoplasms;Mastication;Measures;Mediating;Melons;Metabolic Pathway;metabolomics;Modality;Modeling;mouse model;Mucous Membrane;Mus;Natural Killer Cells;Natural Products;novel;novel therapeutic intervention;Operative Surgical Procedures;Pathway interactions;Patients;Phenotype;Pre-Clinical Model;prevent;Preventive;Process;Prognosis;Radiation therapy;Recurrence;Risk Factors;Risk Reduction;Role;side effect;Signal Transduction;Survival Rate;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Therapeutic Uses;therapeutically effective;Time;Tissues;Tobacco use;transcriptomics;translational impact;Treatment Efficacy;treatment strategy;tumor;tumor growth;tumor metabolism;tumor microenvironment;Untranslated RNA;Vaccination;World Health Organization

PROJECT_TITLE: Developing new therapeutic strategies against head and neck cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Pain Research;Patient Safety;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Knee pain with imaging evidence of meniscal tear is common among middle aged and older persons. The great majority of physicians suggest an initial course of physical therapy for persons with this condition, but there are no studies addressing the best treatment for persons whose pain persists despite PT. This planning grant proposes a range of planning activities to prepare the team to conduct a trial of surgery vs. rigorous nonoperative therapy in persons 45-85 years old with persistent knee pain after PT for meniscal tear.

PI_NAMEs: KATZ, JEFFREY NEIL (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Adherence;Adverse effects;Age;aging population;American;authority;Caring;Certification;Clinical;Clinical Protocols;Clinical Trials;comparative efficacy;cost;cost effectiveness;Data;Degenerative polyarthritis;design;disability;Education;effective therapy;Elements;Eligibility Determination;Ensure;Equipoise;Exercise;exercise program;experience;Future;Grant;Hospitals;human very old age (85+);Hyaluronic Acid;Image;improved;Injection of therapeutic agent;Injections;Institutional Review Boards;Intervention;Intra-Articular Injections;Knee;Knee joint;knee pain;knee replacement arthroplasty;Long-Term Effects;Manuals;meniscal tear;middle age;Modeling;Molecular Weight;Monitor;multimodality;neuromuscular;Older Population;Online Systems;Operative Surgical Procedures;Outcome;Pain;Pain Measurement;pain reduction;pain relief;Patient Self-Report;Patients;Performance;Persistent pain;Persons;Physical Exercise;Physical therapy;Physicians;preference;primary outcome;Procedures;programs;Protocols documentation;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;Regimen;Research;Rest;Risk;Running;Safety;standard of care;Standardization;Statistical Data Interpretation;Symptoms;Syndrome;telehealth;Therapeutic;Tissues;Training;treatment strategy;trial enrollment;trial planning;Triamcinolone;Universities;Woman;Work

PROJECT_TITLE: Surgery vs. conservative care for meniscal tear after unsuccessful PT: an RCT


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Kidney Disease;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative A major function of the proximal tubule of the kidney is to recover proteins that enter the nephron to prevent their escape in the urine. Defective proximal tubule function as a result of genetic mutations or kidney injury leads to tubular proteinuria that can progress to end stage renal disease. Our studies here focus on understanding how mutations in an ion transporter that is mutated in Dent disease leads to impaired protein recovery by the proximal tubule. The results of our research will provide important new information about the mechanism of protein recovery that may help in designing therapies for tubular proteinuria.

PI_NAMEs: WEISZ, ORA A (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Acute;Affect;aging population;Albumins;Apical;apical membrane;Binding;Biochemical;Cell Culture Techniques;Cells;Cholesterol;Chronic;Chronic Kidney Failure;Clinical;CRISPR/Cas technology;Cystinosis;Defect;Degradation Pathway;Dent Disease;design;Development;Diabetes Mellitus;Didelphidae;Disease;disease phenotype;Disputes;DNA Sequence Alteration;Early Endosome;effective therapy;End stage renal failure;Endocytosis;Endosomes;Excretory function;experimental study;Functional disorder;Genes;Genetic;Genetic Diseases;Genetic Transcription;glomerular filtration;Glycogen Synthase Kinase 3;Heavy Metals;Homeostasis;Image;Impairment;inhibitor;Injury to Kidney;intrinsic factor-cobalamin receptor;Ion Transport;Ions;Kidney;kidney cell;kidney dysfunction;Kinetics;knock-down;Knock-out;Knockout Mice;LDL-Receptor Related Protein 2;Ligands;Link;Lysosomes;mathematical model;Medicare;Membrane Protein Traffic;metal poisoning;Modeling;Molecular;Molecular Weight;Morphology;mouse model;Mus;mutant;Mutate;Mutation;Nephrons;novel;Oculocerebrorenal Syndrome;Pathogenesis;Pathway interactions;Patients;Peroxisome Proliferator-Activated Receptors;Persons;PPAR alpha;Prevalence;prevent;Proteins;Proteinuria;Proximal Kidney Tubules;receptor;receptor binding;Recovery;Recycling;Research;restoration;Risk;Route;System;Testing;Therapeutic Intervention;therapeutic target;therapy design;trafficking;Transplantation;Treatment Cost;Tubular formation;United States;uptake;urinary;Urine

PROJECT_TITLE: Endocytic Pathway Dysfunction in Dent Disease

STUDY_SECTION: KMBD

STUDY_SECTION_NAME: Kidney Molecular Biology and Genitourinary Organ Development[KMBD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Hyde - Project Narrative: Venezuelan equine encephalitis virus (VEEV) is a mosquito-borne virus that causes significant human and veterinary diseases, however few vaccines and therapies exist to treat VEEV infections. Viral RNA structure is an understudied determinant of pathogenesis. Understanding how VEEV RNA structure contributes to immune evasion and pathogenesis will shed light on mechanisms of viral emergence and inform development of RNA- based therapeutics.

PI_NAMEs: HYDE, JENNIFER LYNN (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Affect;Alpha Virus;Alphavirus Infections;Animals;arthropod-borne;Attenuated;Biochemical;Brain;Cells;Cellular Tropism;Complement;Culicidae;Development;Disease;Disease Outbreaks;Double-Stranded RNA;draining lymph node;emerging virus;Encephalitis;enzootic;Epidemic;epizootic;Equus caballus;Evolution;fitness;foot;Future;Genes;Genetic;Genetic Transcription;Genome;Growth;Health;Human;Human papillomavirus 16 E1 protein;immune activation;Immune Evasion;Immune response;Immunity;In Vitro;in vivo;Infection;Innate Immune Response;insight;Integration Host Factors;Interferon Activation;Interferons;Licensing;Macrophage;Mediating;Modality;Molecular;mosquito-borne;mouse model;Mus;mutant;Myeloid Cells;Nature;nonhuman primate;novel;Pathogenesis;pathogenic virus;Pathogenicity;Periodicals;Phenotype;Play;prevent;Process;Production;recruit;Regulation;response;RNA;RNA chemical synthesis;RNA Sequences;RNA Stability;RNA Viruses;RNA-Binding Proteins;Role;Shapes;Sindbis Virus;single cell sequencing;structural determinants;Structure;Testing;Therapeutic;therapeutic RNA;tissue tropism;Tissues;Translations;Untranslated Regions;Vaccines;Variant;Venezuelan Equine Encephalitis Virus;Viral;Viral Genome;Viral Pathogenesis;Viral Proteins;viral RNA;viral transmission;Virulent;Virus;Virus Diseases;Virus Inhibitors;Virus Replication;Work

PROJECT_TITLE: Regulation of RNA sensing and viral restriction by RNA structures

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: Moshi

ORG_COUNTRY: TANZANIA U REP

ORG_FIPS: TZ

ORG_NAME: KILIMANJARO CHRISTIAN MEDICAL CENTRE

PHR: Narrative Currently there are highly effective treatments and prevention for HIV infection, but they are not being optimally utilized in low- and middle-income settings. Sociobehavioral determinants and mental illness represent significant obstacles to their full implementation. This D43 application, "Building Research Capacity for Sociobehavioral Sciences and HIV Infection in Tanzania", will continue to build research expertise to address and overcome these obstacles in Tanzanian context.

PI_NAMEs: MMBAGA, BLANDINA THEOPHIL (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Adherence;Adolescent Psychiatry;aging population;AIDS prevention;antiretroviral therapy;Area;Award;Behavior;Behavioral Sciences;Caring;Child;Child Psychiatry;Clinical Research;college;Communities;Community Developments;Community Outreach;comorbidity;Country;Doctor of Philosophy;Elderly;Epidemic;evidence base;faculty mentor;Fellowship;Funding;Future;Gender;Geriatric Psychiatry;Grant;Health;HIV;HIV Infections;HIV-infected adolescents;Human;Human immunodeficiency virus test;Institution;interdisciplinary collaboration;interest;Knowledge;Manuscripts;Medical;Medical center;member;Mental disorders;Mentors;Methods;Occupational Therapist;peer;peer coaching;Persons;Physicians;Pilot Projects;Prevention approach;Prevention strategy;programs;Psychiatry;Psychologist;Publishing;Research;Research Institute;Research Personnel;Science;Scientist;Social Behavior;social determinants;Social Workers;symposium;Tanzania;Training;United States National Institutes of Health;Universities;Vulnerable Populations

PROJECT_TITLE: Building Research Capacity to Address Sociobehavioral Sciences in HIV infection in Tanzania

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(56)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE: The goal of this proposal is to develop and validate a new magnetic resonance imaging (MRI) approach for measuring the severity of fibrosis in the left side of a heart chamber called atrium, for the purpose of predicting whether patients will revert to atrial fibrillation following initial successful intervention. Unfortunately, standard MRI and analysis methods have two fundamental deficiencies (inadequate spatial resolution, unreliability) that hinder accurate reading of fibrosis. Our new approach integrating advanced engineering and MRI physics techniques successfully addresses the deficiencies associated with standard methods and enables doctors to correctly predict recurrent atrial fibrillation following intervention.

PI_NAMEs: KIM, DANIEL  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Adoption;AF2;Agreement;Atrial Fibrillation;Automation;Breathing;Cardiac ablation;Cardiovascular system;Cessation of life;Classification;Clinical;clinical practice;cost;Data;density;Development;Dimensions;Disease;Engineering;Fibrosis;Gadolinium;Goals;Heart;Heart Atrium;Heart failure;high throughput analysis;Image;Image Analysis;imaging approach;Intervention;Left;Life;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Measures;men;Methodology;Methods;Motion;Multicenter Studies;Nature;Noise;novel;novel strategies;Operative Surgical Procedures;Patients;personalized medicine;Physics;Physiologic pulse;Play;precision medicine;Pulmonary veins;Radial;Reading;reconstruction;Recurrence;Reproducibility;Resolution;respiratory;Risk;risk prediction model;Role;Sampling;Scanning;Self Correction;Severities;Side;Sinus;Site;Standardization;statistics;stem;Stroke;success;successful intervention;Techniques;Technology;Thinness;Time;Unnecessary Procedures;Utah;verification and validation;Widespread Disease;Woman

PROJECT_TITLE: Precision MRI of Left Atrial Fibrosis for Patients with Atrial Fibrillation


ORG_CITY: STANFORD

ORG_DEPT: DERMATOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Effective training of scientists capable of successfully conducting independent research is critical for continued progress in biomedical research directed at meeting future public health needs. The Postgraduate Training Program in Epithelial Biology is designed to train new scientists in disciplines relevant to the understanding, prevention and treatment of skin disease.

PI_NAMEs: KHAVARI, PAUL  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Biology;Epithelium;Training

PROJECT_TITLE: Postgraduate Training in Epithelial Biology


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: NARRATIVE The proposed research is relevant to public health because it addresses a novel treatment strategy for hepatocellular carcinoma (HCC), the third most common cause of cancer-related death worldwide. The proposed research is relevant to the NCI’s mission of supporting research with respect to the treatment of cancer.

PI_NAMEs: SHETH, RAHUL ANIL (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Abscopal effect;Address;Affect;Agonist;Blood Vessels;Cancer Etiology;cancer therapy;Cessation of life;Clinical;clinical translation;Clinical Trials;combat;cytotoxic CD8 T cells;Data;Death Rate;Deposition;design;Devices;Dose;Drug Delivery Systems;drug distribution;Engineering;Foundations;Generations;Goals;Hour;Hyperthermia;image guided;image guided intervention;Immune;immune activation;Immune response;Immunologics;immunostimulatory therapy;Immunotherapy;improved;Injections;innovation;interstitial;Knowledge;liver cancer model;Mediating;minimally invasive;Mission;Multimodal Imaging;Needles;Neoplasm Metastasis;Normal tissue morphology;novel;novel therapeutic intervention;Patients;Perfusion;Pharmaceutical Preparations;preclinical study;pressure;Primary carcinoma of the liver cells;Primary Neoplasm;Public Health;radio frequency;Rattus;Research;Research Support;Site;Stimulator of Interferon Genes;success;System;Systemic Therapy;systemic toxicity;T cell infiltration;targeted delivery;Techniques;Technology;Testing;Time;time interval;tool;translational impact;Treatment Efficacy;treatment strategy;trend;tumor;tumor hypoxia;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Variant

PROJECT_TITLE: An image-guided immunotherapy and hyperthermia delivery device to overcome barriers to tumor immunity for advanced hepatocellular carcinoma


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: Project Narrative Our study will provide a new mechanistic understanding of brain tumor cell biology during their interaction with normal brain cells and identify a new set of genetic and epigenetic drivers that can be targeted in our large panel of organoids and PDOX mouse models of pediatric malignant brain tumors.

PI_NAMEs: LI, XIAONAN  (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Address;Affect;Age;age group;Autopsy;Biological;Biological Assay;Biological Models;Biology;Brain;brain cell;Brain Neoplasms;Brain Stem;brain tissue;Cancer Etiology;Cancer Model;cancer stem cell;cancer survival;Cell Survival;cell type;Cells;Cerebellum;Cerebrum;Child;Childhood;Childhood Brain Neoplasm;childhood cancer mortality;Childhood Malignant Brain Tumor;Coculture Techniques;Collection;Cryopreservation;Development;Ependymoma;Epigenetic Process;Future;Gene Modified;Genetic;Goals;Growth;Growth Factor;histone methylation;histone modification;Hypoxia;implantation;In Vitro;in vitro Model;in vivo;in vivo Model;Intracranial Neoplasms;Location;Malignant neoplasm of brain;Medulloblastoma;Methylation;Modeling;Molecular;molecular subtypes;mouse model;multiple omics;Mus;Mutation;neoplastic cell;Neurosphere;new combination therapies;novel therapeutics;Operative Surgical Procedures;Organoids;Patients;Positioning Attribute;Proliferating;Protocols documentation;Radiation;Radiation therapy;radioresistant;Resistance;response;Role;self-renewal;Series;single-cell RNA sequencing;small molecule;Source;Starvation;stem cell survival;subventricular zone;Testing;Tissues;Treatment Protocols;tumor;Tumor Biology;Tumor Cell Biology;Tumor Stem Cells;Tumor Tissue;tumor xenograft;Validation;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Matching panels of in vivo and in vitro model system of pediatric brain tumors


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

PHR: Project Narrative Cancer poses a debilitating public health crisis. A hallmark of cancer cells is their ability to grow in the face of stressors such as aneuploidy, nutrient scarcity, and xenobiotic compounds. The proposed research will investigate a novel gene, C16orf72, which we recently discovered to be a powerful regulator of stress resilience in cancer cells and may be a viable target to reduce cancer growth and prevent the development of therapy resistance.

PI_NAMEs: AMICI, DAVID RUSSELL (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Amino Acids;Aneuploidy;Binding;Biochemical;biological adaptation to stress;Breast Cancer Cell;Breast Cancer Model;Breast Cancer therapy;cancer cell;Cancer Cell Growth;Cancer cell line;cell growth regulation;Cell Line;Cell Survival;Cells;Cellular Stress;Chemoresistance;chemotherapy;Co-Immunoprecipitations;Complex;Cyclophosphamide;Data;Development;Dimerization;empowerment;environmental stressor;experimental study;Fellowship;fitness;Funding;Genes;Genetic;genome-wide;genotoxicity;Goals;Growth;Heat-Shock Response;Homodimerization;Human;Hypoxia;improved;in vivo;Individual;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Measures;Mediating;Messenger RNA;Modeling;Modification;Molecular;Molecular Sieve Chromatography;Mus;Mutagens;mutant;Neoplasm Metastasis;novel;Nutrient;Oncogenic;Pathway interactions;Phenocopy;Phenotype;Physiological;prevent;programs;promote resilience;Proteins;Proteome;proteotoxicity;Public Health;Research;Resistance;response;Role;screening;Series;Stress;stress resilience;Stress Response Signaling;stress state;stressor;System;Testing;Therapeutic;therapeutic evaluation;therapy development;transcriptomics;tumor;tumor growth;tumorigenesis;ubiquitin-protein ligase;Ubiquitination;Work;Xenobiotics;Xenograft procedure

PROJECT_TITLE: Elucidating the Role of C16orf72 in the Cellular Stress Response Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Cancer

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: Project Narrative Protein glycosylation and trafficking is an essential biological process that is intimately linked to tumorigenesis and cancer progression. Our structure-function studies on enzymes involved in protein mannosylation and the coupling between lipid flipping and membrane bending will fill a knowledge gap. The derived structures will facilitate the development of small molecules targeting these enzymes for potential cancer treatment.

PI_NAMEs: LI, HUILIN  (contact)

PROGRAM_OFFICER_NAME: KYI, CINDY WIN

PROJECT_TERMS: Address;ADP-Ribosylation Factors;alpha helix;Back;Binding;Biogenesis;Biological Process;C-terminal;cancer therapy;Catalytic Domain;Cell membrane;Cells;Clathrin-Coated Vesicles;Complex;Couples;Coupling;Development;dimer;Docking;Dolichyl-phosphate-mannose-protein mannosyltransferase;Early Endosome;Endosomes;Enzymes;Eukaryota;Family;Family member;Funding;glycosylation;glycosyltransferase;Goals;GTPase-Activating Proteins;Guanine Nucleotide Exchange Factors;Guanine Nucleotides;Guanosine Triphosphate Phosphohydrolases;Human;Hydrophobicity;In Vitro;Knowledge;Link;Lipid Bilayers;Lipids;Location;Lysosomes;mannose 6 phosphate;Mannosyltransferases;Mediating;member;Membrane;Membrane Proteins;Molecular;Monomeric GTP-Binding Proteins;N-terminal;Pathologic;Phosphatidylserines;Phosphotransferases;Play;polypeptide;prevent;Process;protein complex;Protein Glycosylation;protein structure;protein transport;protein-O-mannosyltransferase 1;protein-O-mannosyltransferase 2;Proteins;Proteome;reconstitution;recruit;Resolution;Ribosomes;Role;Rough endoplasmic reticulum;Series;Signal Transduction;small molecule;Sorting;Structure;Tail;Testing;Therapeutic;trafficking;trans-Golgi Network;Transcription Factor AP-1;Transmembrane Domain;Travel;tumor progression;tumorigenesis;Vesicle;vesicle transport;Yeasts

PROJECT_TITLE: Molecular mechanisms of protein glycosylation and trafficking

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric

PHR: PROJECT NARRATIVE Many bilingual students entering US schools learned foundational concepts in a language other than English, leaving them at a potential developmental disadvantage compared to their monolingual peers when tested on this knowledge in English. This proposal investigates how the bilingual brain processes foundational knowledge that is thought to be affected by the unique experience of being bilingual, including memorized multiplication facts and basic scientific concepts. The outcome of this research will help determine how bilingual children learn and use foundational knowledge in each of their languages, as well as elucidate the relationship between language, development, and the bilingual brain more generally.

PI_NAMEs: CERDA, VANESSA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Adult;Affect;Applications Grants;Area;Arithmetic;Basic Science;Behavior;behavior measurement;bilingualism;Brain;Brain imaging;Brain region;career;career development;career networking;Child;Child Development;Cognition;Cognitive;Coupled;Data;demographics;Development;Disadvantaged;Disparity;Education;Environment;Event-Related Potentials;experience;experimental study;Fellowship;Functional Magnetic Resonance Imaging;Future Generations;Goals;Grant;Growth;indexing;innovation;Instruction;interdisciplinary approach;Knowledge;Language;Learning;Literature;mathematical model;Mathematics;Measures;Memory;Mentorship;method development;Methodology;Methods;Modeling;multimodal neuroimaging;neural;neural network;Neurocognitive;neuroimaging;Outcomes Research;Parietal Lobe;peer;Performance;Population;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Process;programs;Publications;Reaction Time;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;response;Retrieval;Schools;Science;skills;Students;support network;Technology;Temporal Lobe;Testing;Time;tool;Training;Translations;United States;Work;Writing

PROJECT_TITLE: The effect of language experience on a bilingual's ability to process arithmetic and other memorized facts


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE Relapse remains a leading cause of death for patients with B-cell acute lymphoblastic leukemia. Using single- cell studies of primary diagnosis samples from patients, we can identify cells responsible for future relapse at the time of diagnosis. Building a model of relapse risk prediction based on the presence of these cells will enable rapid, accurate, and actionable relapse prediction moving closer to the goal of preventing relapse.

PI_NAMEs: DAVIS, KARA LYNN (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Acute Lymphocytic Leukemia;Address;Adoption;Automobile Driving;B-Cell Acute Lymphoblastic Leukemia;B-Lymphocytes;Biology;Cancer Etiology;Cause of Death;Cell Adhesion;Cells;chemotherapy;Child;Childhood Leukemia;Classification;Clinical;clinical implementation;clinical risk;Clinical Trials;cohort;Complex;CREB1 gene;Data;data-driven model;Diagnosis;Diagnostic;differential expression;Disease;DNA Sequence Alteration;exome sequencing;Future;Gene Mutation;Genetic;Genomics;Goals;Immunotherapeutic agent;Immunotherapy;improved;Incidence;Individual;individual patient;innovation;Institution;leukemia;Leukemic Cell;Machine Learning;machine learning model;machine learning prediction;Measurement;Measures;Medicine;Membrane Proteins;Methods;Modeling;Molecular;mortality;multimodality;Mutation;mutational status;Nature;novel;Oncogenic;Pathway interactions;Patients;Performance;Phenotype;Population;precision medicine;predictive modeling;prevent;prospective;prospective test;Proteins;Proteomics;prototype;Publishing;Recurrence;Recurrent disease;Relapse;relapse prediction;relapse prevention;relapse risk;response;Risk;Risk Assessment;risk prediction;risk prediction model;Sampling;Signal Transduction;standard of care;Surface;SYK gene;targeted treatment;Therapeutic;therapeutic target;Time;treatment response;treatment strategy;Work

PROJECT_TITLE: Predicting Relapse at the Time of Diagnosis in Acute Lymphoblastic Leukemia

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Outcomes after stroke remain poor. The overall goal of the proposal is to develop and test new nanoparticles that specifically target the brain after stroke and slowly deliver high doses of medications to protect the stroked brain region over several days and improve outcomes.

PI_NAMEs: HYDER, DEWAN SYED FAHMEED;SANSING, LAUREN H (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Acidosis;Aftercare;anaerobic glycolysis;Anti-Inflammatory Agents;behavioral outcome;biomaterial compatibility;Biomedical Engineering;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier crossing;blood-brain barrier penetration;Brain;Brain Ischemia;Brain region;brain tissue;Carbon Dioxide;Cell Death;Cells;Cerebral Ischemia;cerebroprotection;Cerebrum;Clinical;cognitive testing;cohort;cytokine;design;disability;Disease;Dose;drug candidate;Drug Delivery Systems;drug efficacy;Drug Targeting;drug testing;Edema;Effectiveness;efficacy testing;Encapsulated;Energy Supply;Energy-Generating Resources;Environment;Event;excitotoxicity;Experimental Models;extracellular;Formulation;functional outcomes;Gadolinium;Glucose;Goals;Habitats;Hemorrhage;Histology;Hypoxia;imaging scientist;Immunofluorescence Immunologic;Immunologist;improved;improved outcome;in vivo;Infarction;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Injections;Injury;Ischemia;ischemic lesion;Ischemic Stroke;Leukocytes;lipid nanoparticle;Macrophage;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measures;Metabolism;Metformin;Methods;Microglia;Middle Cerebral Artery Occlusion;Modeling;mortality;mouse model;MRI Scans;Mus;nanoparticle;Nervous System Trauma;neurobehavioral;neuroinflammation;Neurologist;novel;Outcome;oxidative damage;Oxygen;Pathway interactions;Pharmaceutical Preparations;Pilot Projects;Pioglitazone;post stroke;Production;recruit;Reperfusion Therapy;Saline;Stroke;stroke outcome;targeted treatment;Testing;Therapeutic Intervention;Thrombectomy;thrombolysis;Tissues;translational potential;translational therapeutics;treatment effect;United States;Validation;Work

PROJECT_TITLE: Hypoxia and pH Responsive Nanoparticles for Targeted Drug Delivery to Ischemic Stroke

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Prevention;Substance Misuse

ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: KENYATTA  NATIONAL  HOSPITAL

PHR: PROJECT NARRATIVE The proposed program, “Integrating prevention and treatment of non-communicable diseases and HIV care through research training in Kenya-INTEGRATE,” will train health professionals at Kenyatta National Hospital (KNH) and the Kenya Ministry of Health (MOH) to conduct implementation science and epidemiology research that will improve non-communicable disease (NCD) prevention, diagnosis and treatment for people living with HIV (PLWH). This renewal application strives to build sustainable research capacity through advanced research training at University of Nairobi (UoN) and University of Washington (UW), as well as support career development of junior researchers at KNH. In this way, our program will contribute solutions to the pressing need to provide comprehensive HIV and NCD care, and achieve higher quality of life and sustainable reductions in preventable deaths among PLWH.

PI_NAMEs: FARQUHAR, CAREY ;KINUTHIA, JOHN  (contact)

PROJECT_TERMS: Advisory Committees;Anti-Retroviral Agents;Cardiovascular Diseases;Caring;Chronic lung disease;Collaborations;Department chair;Disease;Doctor of Philosophy;E-learning;Educational process of instructing;Ensure;Epidemic;Epidemiology;Evolution;Fellowship;Foundations;Future;global health;Grant;Guidelines;Head;Health;Health Professional;HIV;hospital care;Hospital Referrals;Hospitals;Human immunodeficiency virus test;implementation science;improved;Institution;institutional capacity;K-Series Research Career Programs;Kenya;Malignant Neoplasms;Mental Health;Mentors;Metabolic Diseases;next generation;Persons;Policies;post-doctoral training;Postdoctoral Fellow;prevent;Prevention;programs;Public Health;Research;Research Activity;research and development;Research Methodology;Research Personnel;Research Training;Solid;success;Training;Training Support;Translating;Universities;Viral;Vision;Washington;Work


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Prevention

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative  This project will advance statistical methodology for measuring HIV incidence and develop a new class of efficacy trial design to evaluate future HIV preventive interventions. These methods are greatly needed because use of current highly resource-efficient estimates of incidence (HIV recency assays, which provide information on the timing of HIV acquisition) are limited due to lack of precision. In addition, traditional clinical trial designs may soon prove infeasible since effective HIV preventive interventions currently exist. 1

PI_NAMEs: GAO, FEI  (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: active control;AIDS prevention;Anti-Retroviral Agents;arm;Biological Assay;Characteristics;Classification;Clinical Trials Design;cohort;Communicable Diseases;Complex;Data;design;Development;direct application;effectiveness measure;effectiveness study;efficacy evaluation;efficacy trial;Evaluation;Future;high risk;HIV;Human immunodeficiency virus test;implementation barriers;improved;Incidence;Individual;Infection;innovation;insight;Intervention;Intervention Trial;Left;Measures;Methodology;Methods;next generation;novel;Participant;Performance;Phase;Placebo Control;Placebos;Population;Population Analysis;population based;Positioning Attribute;prevent;Prevention;prevention efficacy trial;preventive intervention;Property;Prophylactic treatment;randomized trial;randomized, controlled study;Relaxation;Research;Resources;Sampling;screening;Sexually Transmitted Diseases;simulation;Source;Statistical Methods;success;Testing;Time trend;tool;trial design;volunteer

PROJECT_TITLE: Statistical Methods for Advancing HIV Prevention

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE This implementation research project aims to test the effectiveness of an implementation strategy entitled: “Systems Analysis and Improvement Approach” for use in global mental health systems improvement (SAIA- MH). This approach targets helping health workers in low-resource settings globally improve the delivery of outpatient mental healthcare. For example, helping workers improve patient retention in care, medication adherence, and improvement of function.

PI_NAMEs: WAGENAAR, BRADLEY  (contact)

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Adherence;Advocate;Affect;Area;Attention;attentional control;budget impact;care systems;Caring;Climate;Clinical;clinically significant;Complex;Consolidated Framework for Implementation Research;Consultations;cost;cost effectiveness;cost estimate;Data;design;Development;Diagnosis;Diagnostic;disability;Drops;effective therapy;Effectiveness;effectiveness testing;Engineering;Equation;evidence base;Facility Controls;follow-up;functional improvement;Goals;Health;health care delivery;Health Personnel;Health Services Accessibility;Health system;HIV;implementation determinants;implementation research;implementation strategy;improved;Infant;Information Systems;innovation;Intervention;Knowledge;Learning;Link;low and middle-income countries;Maintenance;Maps;markov model;medication compliance;Mental disorders;Mental Health;Mental Health Services;microcosting;Modeling;Modification;Mother-to-child HIV transmission;Motion;Mozambique;organizational structure;Outcome;Outpatients;Pathway interactions;patient retention;Patient-Focused Outcomes;Patients;Performance;Persons;Phase;Policies;Prevention;Procedures;Process;Provider;Quality of Care;Reporting;Research Project Grants;Resource-limited setting;response;retention rate;scale up;Schizophrenia;success;Symptoms;System;Systems Analysis;Testing;Time;tool;Treatment Step;Visualization;Work

PROJECT_TITLE: Systems Analysis and Improvement Approach to Optimize the Task-Shared Mental Health Treatment Cascade (SAIA-MH): A ClusterRandomized Trial

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Narrative The T cell-specific DNA binding protein TCF-1 has two main isoforms and performs multiple stage- and lineagespecific epigenetic functions during T cell development but there is a gap in our knowledge on how TCF-1 leverages these stage- and context-specific functions. Optimally addressing this gap in knowledge without confounding developmental defects resulting from long- term TCF-1 deficiency requires inducible short-term manipulation of the protein levels of selective TCF-1 isoforms at specific stages of T cell development. Therefore, we propose to generate and validate animal models that allow auxin-inducible, in vivo short-term degradation of TCF-1 isoforms to record in time their molecular and epigenetic functions.

PI_NAMEs: GOUNARI, FOTINI  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 3-Dimensional;Acetic Acids;Acute;Address;Affect;Animal Model;ATAC-seq;Auxins;beta catenin;Binding;CD8B1 gene;Cell Lineage;Cells;cellular development;Chromatin;Communities;Complex;Defect;Development;DNA;DNA-Binding Proteins;Epigenetic Process;functional outcomes;Gene Expression;Gene Expression Profile;genetic regulatory protein;genome-wide;high reward;high risk;Histone Deacetylase;in vivo;insight;Kinetics;Knowledge;Length;Ligands;Mediating;Modeling;Molecular;Molecular Conformation;mouse model;Mus;novel;Oryza sativa;protein degradation;Protein Isoforms;Proteins;recruit;Research;Resources;response;Shapes;Site;stem cells;T cell transcription factor 1;T-Cell Development;T-Lymphocyte;thymocyte;Time;Tissues;tool;Transcription Coactivator;transcriptome sequencing;ubiquitin-protein ligase;WNT Signaling Pathway

PROJECT_TITLE: Tools for reversible short-term degradation of TCF-1 to address its molecular functions

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Precision Medicine;Rare Diseases;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE In pre-clinical models of head and neck cancer (HNC), exposure to chronic stress leads to increased tumor growth and metastasis. Although the underlying mechanisms remain uncertain, our preliminary data have implicated the SDF-1/CXCR4 pathway in this stress-induced cancer growth. Through both pre-clinical and clinical investigations, including a novel mouse model of chronic stress with a humanized immune system, this study will shed light on the underlying mechanisms and clinical relevance of stress-induced HNC growth, providing a foundation for the development of precision therapeutics.

PI_NAMEs: ZENGA, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: AMD3100;Animal Model;Animals;antagonist;arm;Autologous;Biological Models;bone;Bone Marrow;cancer cell;Cancer cell line;cancer recurrence;cancer surgery;carcinogenesis;CD34 gene;Cell Line;chemoradiation;Chronic;Chronic stress;Clinical;clinical investigation;Clinical Research;Clinical Trials;Clinical Trials Design;clinically relevant;Complex;CXCR4 gene;cytokine;Data;Deglutition;design;Development;Disease;Disease Outcome;Disease-Free Survival;drug development;Engineering;Engraftment;Excision;experience;experimental study;Exposure to;fibula;Foundations;Gene Expression Profile;Growth;Harvest;Head and Neck Cancer;head and neck cancer patient;Hematopoietic stem cells;High Prevalence;high risk;High-Risk Cancer;HPV-negative head and neck cancer;Human;human stem cells;humanized mouse;Immune;Immune response;Immune system;immunodeficiency;Immunodeficient Mouse;Immunophenotyping;Immunosuppression;improved;in vivo Model;Injections;Intervention;Investigation;Ligands;Link;Malignant Neoplasms;Measures;Metastatic Neoplasm to the Lung;Methodology;Modeling;mouse model;Mouth Neoplasms;Mus;Neoplasm Metastasis;novel;Observational Study;Operative Surgical Procedures;Oropharyngeal;Outcome;Pathway interactions;patient derived xenograft model;Patient Recruitments;patient subsets;Patients;personalized approach;Plasma;Play;Population;pre-clinical;Pre-Clinical Model;Precision therapeutics;Prognosis;prospective;Randomized;reconstruction;recruit;Research Design;Role;Sampling;Social isolation;socioeconomic adversity;socioeconomics;Specimen;Speech;Stress;stressor;Stromal Cell-Derived Factor 1;Surgical Flaps;System;Testing;Therapeutic;Time;transcriptome sequencing;Transplantation;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor-Derived;Umbilical Cord Blood;Up-Regulation;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Determining the role of the SDF-1/CXCR4 pathway and its intersection with chronic stress to establish novel precision approaches to head and neck cancer management

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Diabetes;Genetics;Human Genome;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative The pandemic of obesity is a major cause of the increased incidence of type 2-diabetes and cardiovascular diseases. Excessive storage of calories in white adipose tissue (WAT) leads to infiltration of inflammatory cells and deposition of fibrogenic material, which with time causes disruption of overall metabolism and energy balance. The proposed studies are designed to identify the mechanisms responsible for the progressive decline in adipocyte functions and the role of changes in cellular complexity of WAT in response to the consumption of chronic high fat diet.

PI_NAMEs: FARMER, STEPHEN ROBERT (contact);LAYNE, MATTHEW D

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Actins;Adipocytes;Adipose tissue;angiogenesis;Blood Vessels;Calories;Cardiovascular Diseases;Cell Communication;Cell Compartmentation;Cell Count;cell type;Cells;Chromatin;Chronic;cofactor;Collagen Type VI;Consumption;Cytoskeletal Proteins;Cytoskeleton;Data;Deposition;design;Development;Diabetes Mellitus;Diet;diet-induced obesity;energy balance;Epigenetic Process;Extracellular Matrix;fibrogenesis;Fibrosis;Focal Adhesions;Functional disorder;Gene Expression;Gene Expression Profile;genetic manipulation;Genetic Transcription;Goals;High Fat Diet;Hyperplasia;Hypertrophy;Hypoxia;Immune;In Vitro;Incidence;Inflammation;Inflammatory Infiltrate;Integrins;Investigation;Knowledge;lipid biosynthesis;Macrophage;Malignant Neoplasms;MAP Kinase Gene;mechanical signal;Mechanical Stress;MEKs;Mesenchymal Stem Cells;mesenchymal stromal cell;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;myocardin;Non-Insulin-Dependent Diabetes Mellitus;Obese Mice;Obesity;osteopontin;p38 Mitogen Activated Protein Kinase;pandemic disease;Pathologic;Pathway interactions;Phenotype;Platelet-Derived Growth Factor alpha Receptor;Population;Production;progenitor;programs;recruit;response;Risk Factors;Role;senescence;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;stem cell fate;stem cells;Therapeutic;Thinness;Time;Tissues;transcription factor;transcriptome sequencing;Visceral

PROJECT_TITLE: Deconstructing the diet-induced remodeling of adipose tissue

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Malaria;Pediatric;Prevention;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The proposed project is relevant to public health because evidence on the health and socioeconomic impact, safety, and cost-effectiveness of detecting and treating low-density malaria infections in children has high potential to inform malaria policy and practice and decrease the global burden of disease due to malaria. The project is relevant to NIAID’s mission to conduct applied research to understand, treat, and prevent infectious diseases.

PI_NAMEs: HSIANG, MICHELLE SANG (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: 10 year old;Address;African;Anemia;Antibiotics;Applied Research;Area;arm;artemether;Bacterial Infections;benflumetol;burden of illness;Child;Child Health;Child Welfare;Childhood;Chronic;Clinical;co-infection;Cognition;Cognitive;Cognitive deficits;Cohort Studies;Communicable Diseases;Communities;comparison control;comparison intervention;cost;cost effectiveness;cost-effectiveness evaluation;Country;Data;density;Detection;detection method;Diagnosis;Diagnostic;Diagnostic tests;disability-adjusted life years;Drug resistance;economic cost;economic impact;Economics;Effectiveness;efficacy evaluation;Evaluation;Failure;Falciparum Malaria;Fever;follow-up;Future;global health;Growth;Health;Health care facility;health economics;high risk;Immune response;Immunity;Impaired cognition;improved;Incidence;Infection;innovation;Intervention;Malaria;malaria infection;malaria transmission;Methods;Microscopic;Microscopy;Mission;Molecular;Morbidity - disease rate;National Institute of Allergy and Infectious Disease;open label;Outcome;overtreatment;Parasites;Patients;Pediatric cohort;Persons;Pharmaceutical Preparations;Plasmodium falciparum;point-of-care diagnostics;Policies;Population;Prevalence;prevent;Preventive therapy;primary outcome;Privatization;protective effect;Public Health;Randomized;Randomized, Controlled Trials;Rapid diagnostics;Recommendation;recruit;Recurrence;Reporting;Risk;Role;Safety;Sampling;secondary outcome;Side;Site;Societies;socioeconomics;standard of care;Symptoms;Tanzania;Test Result;Testing;three-arm study;tool;Toxic effect;transmission process;treatment strategy;Uganda;Visit

PROJECT_TITLE: Long-term health and socioeconomic impact of interventions targeting low-density malaria infection (LMI) among children in Tanzania


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Lung;Prevention

ORG_CITY: LEBANON

ORG_NAME: CELDARA MEDICAL, LLC

ORG_STATE: NH

PHR: NARRATIVE Hantaviruses such as Andes virus (ANDV) and Sin Nombre virus (SNV) are rodent-borne viruses that cause highly lethal disease in humans. No approved drugs or vaccines exist to treat or prevent hantavirus infection. We will exploit proprietary technology and an experienced multidisciplinary team to develop potent neutralizing antibodies against ANDV. The successful development of this potent antibody-based therapeutic against ANDV has the potential to be a first-line antiviral for the treatment or prevention of hantavirus cardiopulmonary syndrome (HCPS).

PI_NAMEs: BOTTEN, JASON W.;MURAD, JOANA M (contact)

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: Academia;Acute;Advanced Development;aerosolized;Affect;Americas;Andes Virus;Animals;Anti-viral Agents;Antibodies;Antibody Therapy;Area;Argentina;B-Lymphocytes;biosecurity;Bioterrorism;Canada;candidate selection;Cardiogenic Shock;Cardiopulmonary;Case Fatality Rates;Category A pathogen;Classification;Clinical;clinical development;Collaborations;cross reactivity;Deer Mouse;Development;Disease;Disease Outbreaks;Dose;Ebola virus;experience;Family;Family health status;Family member;Fatality rate;FDA approved;Frequencies;future pandemic;Glycoproteins;Goals;Government;Hamsters;Hantavirus;Hantavirus Infections;Health Personnel;Human;human monoclonal antibodies;Immune;Immune Plasma;Immune Sera;Immunize;Immunologist;in vivo;Industry;industry partner;infected vector rodent;Infection;Mammals;manufacturability;manufacture;Maps;Mesocricetus auratus;Modeling;Molecular;Monoclonal Antibodies;Monoclonal Antibody Therapy;multidisciplinary;Mus;National Institute of Allergy and Infectious Disease;Nature;neutralizing antibody;neutralizing monoclonal antibodies;North America;pandemic disease;pandemic potential;Patients;Pharmaceutical Preparations;Phase;Plasmablast;Population;preclinical development;Preparation;prevent;Prevention;priority pathogen;Prophylactic treatment;Pulmonary Edema;Research;Respiratory Failure;Risk;Rodent;Security;Sin Nombre virus;Small Business Technology Transfer Research;South American;Specificity;Syndrome;Technology;Therapeutic;Therapeutic antibodies;therapeutically effective;Tissues;Toxic effect;transmission process;vaccine access;Vaccines;Viral;viral outbreak;Virus;weather patterns;Work

PROJECT_TITLE: A human monoclonal antibody therapy for treatment of hantavirus cardiopulmonary syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-F(12)]


ADMINISTERING_IC: EY

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: STATE COLLEGE OF OPTOMETRY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Retinal diseases lead to visual impairment or blindness and we are in search of approaches to regenerate the retina and restore vision. This project examines microRNAs as key regulators of retinal progenitor cell state and subsequent neuronal cell fate specification in postnatal retinal development. The results will reveal microRNA candidates that can not only function as reprogramming factors to convert endogenous retinal glia cells into neurons but also can serve as therapy to prevent cell degeneration in order to restore or preserve normal retinal function.

PI_NAMEs: WOHL, STEFANIE G (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: 3' Untranslated Regions;3-Dimensional;Address;Age related macular degeneration;antagonist;Architecture;Binding;Biological Assay;biomarker identification;Blindness;candidate selection;cell behavior;Cell Cycle;cell fate specification;Cell Physiology;Cell Proliferation;cell replacement therapy;Cell Reprogramming;cell type;Cells;Cyclin D1;Data;Development;Disease;Disease Progression;Electrophysiology (science);Enzymes;experimental study;Fishes;Gene Expression;Gene Expression Profile;Generations;Genes;Goals;In Vitro;in vivo;innovation;Ions;Lead;Malignant Neoplasms;Measures;Messenger RNA;MicroRNAs;Molecular;Monitor;Morphology;Muller's cell;Mus;Natural regeneration;Neural Retina;Neuroglia;Neurons;Organism;overexpression;patch clamp;Pathologic;Photoreceptors;Play;Postdoctoral Fellow;postnatal;postnatal development;preservation;prevent;programs;Proliferating;Property;Regenerative Medicine;Regulation;repaired;Reporter;Resources;restoration;Retina;Retinal Degeneration;Retinal Diseases;retinal neuron;retinal progenitor cell;retinal regeneration;retinal rods;Retinitis Pigmentosa;retinogenesis;Rod;Role;sensor;sight restoration;single-cell RNA sequencing;Source;stem cell therapy;stem cells;Supplementation;Testing;Therapeutic Agents;Therapeutic Uses;therapy development;Tissues;tool;transcription factor;transplantation therapy;Validation;Visual impairment;Visualization;Work

PROJECT_TITLE: The Role of Retinal Progenitor microRNAs for Late-stage Progenitor Cell State and Muller Glia Reprogramming

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Cognitive dysfunction is central to neurological disorders such as PD and related dementias, and several psychiatric disorders. We will for the first time decipher the individual roles of cortical norepinephrine and dopamine in motivation, learning, and their contribution to cortico-striatal circuits and striatal dopamine dynamics. Through our proposed studies, we will not only advance our understanding of basic catecholamine biology in the brain, but also help devise innovative strategies to modulate activity of these neuromodulators and cortico-striatal subcircuits, and develop novel targeted therapies to counteract cortical catecholamine dysfunction in dementias and neurological disorders.

PI_NAMEs: URS, NIKHIL  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Address;Affect;Anatomy;Basal Ganglia;Behavior;Biology;Brain;Catecholamines;Cognition;Cognitive;cognitive enhancement;cognitive reappraisal;Corpus striatum structure;cortical catecholamine;dalton;Data;Dementia;designer receptors exclusively activated by designer drugs;Disease;Dopamine;Dopamine Receptor;DRD2 gene;Exhibits;extracellular;Fiber;flexibility;Functional disorder;Ganglia;Genetic;Goals;Heterogeneity;hippocampal pyramidal neuron;Impaired cognition;Incentives;Individual;innovation;Knock-out;Knockout Mice;Lateral;Learning;Lesion;Literature;LoxP-flanked allele;Medial;Mental disorders;Midbrain structure;Molecular;motivated behavior;Motivation;Mus;Nervous System Disorder;Neurodegenerative Disorders;Neuromodulator;Neurons;neuropsychiatric disorder;neuropsychiatry;new therapeutic target;Noise;noradrenaline transporter;Norepinephrine;Nose;novel;novel therapeutic intervention;Outcome;Oxidopamine;Pathology;Pattern;Performance;pharmacologic;Photometry;Play;Prefrontal Cortex;Regulation;Reversal Learning;Role;Signal Transduction;Testing;Therapeutic;Time;Yin

PROJECT_TITLE: Role of cortical catecholamines in regulating motivated behavior and striatal dopamine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-T(02)M]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative STING is an essential adaptor protein in the innate immunity against pathogens and cancer. Small molecular drugs targeting STING have potential in treatment of viral infection and cancer. This project is aimed at deepening our understanding of the regulatory mechanisms of STING and designing novel drug-like activators of STING for research and potentially further usage in clinic.

PI_NAMEs: BAI, XIAOCHEN ;CHEN, CHUO ;ZHANG, XUEWU  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Adaptor Signaling Protein;Agonist;anti-cancer;anti-PD-1;anti-PD-L1 antibodies;anti-PD1 antibodies;Anti-viral Response;Antigen-Presenting Cells;Antineoplastic Agents;Autophagocytosis;Bacteria;Binding;Binding Sites;Biological Assay;Biophysics;C-terminal;cancer cell;Cancer Patient;cancer therapy;cancer type;Cell Aging;Cell membrane;Cells;Chemicals;chemokine;Clinic;Clinical Trials;Cryoelectron Microscopy;Cyclic GMP;Cytoplasm;Cytosol;Data;Defect;Dendritic Cells;design;Development;DNA;DNA Binding;DNA Damage;DNA Viruses;Effectiveness;endoplasm;Enzymes;fighting;Foundations;Future;Gene Activation;Goals;Golgi Apparatus;Guanosine Triphosphate;Head;Human;hydrophilicity;Immune;Immune checkpoint inhibitor;Immune response;immunodeficiency;Immunotherapy;Impairment;improved;Infection;Inflammatory Response;Integral Membrane Protein;interest;Interferon Type I;Interferons;Invaded;IRF3 gene;Ligand Binding;Ligand Binding Domain;loss of function;Macrophage;Malignant Neoplasms;Mediating;Membrane;Metabolic;Molecular;Molecular Conformation;molecular drug target;Mutation;Natural Immunity;Nature;neoplastic cell;NF-kappa B;novel;novel strategies;novel therapeutics;Oral;palmitoylation;pathogen;Pathway interactions;Phagosomes;Pharmaceutical Preparations;Phosphotransferases;Play;polymerization;Polymers;Production;recruit;Research;Resolution;response;Role;scaffold;Second Messenger Systems;sensor;Side;Signal Pathway;Signal Transduction;Signaling Protein;Stimulator of Interferon Genes;Structure;synergism;T-Cell Activation;T-Lymphocyte;Tail;TANK-binding kinase 1;targeted cancer therapy;Testing;Therapeutic;tool;transcription factor;Transmembrane Domain;tumor;Tumor Immunity;Viral Cancer;viral DNA;Virus;Virus Diseases;Work

PROJECT_TITLE: Novel regulatory mechanisms and agonists of STING

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases

ORG_CITY: SANTA CLARA

ORG_NAME: INVENIO IMAGING INC.

PHR: Project Narrative Lung cancer accounts for about 25% of all cancer deaths in the US, since it is often caught at an advanced stage when treatment options are limited. This has led to the institution of screening programs with low-dose CT, resulting in ~1.6 million pulmonary nodules detected every year, most of them (~80%) in the periphery of the lung. We propose the development of an FDA-cleared medical device that allows microscopic imaging of fresh, unprocessed tissue biopsies in the treatment room and that would provide accurate, near real-time diagnosis based on deep learning to identify tissue biopsies that are of diagnostic quality.

PI_NAMEs: AKULIAN, JASON A.;FREUDIGER, CHRISTIAN  (contact);HUSTA, BRYAN CHRISTOPHER;OST, DAVID EDWARD

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: Ablation;Address;Algorithms;Area Under Curve;Artificial Intelligence;aspirate;Biomedical Engineering;Biopsy;Biopsy Specimen;Brain Neoplasms;Bronchoscopy;Cancer Detection;Cancer Patient;Cells;Certification;Cessation of life;Classification;Clinical;cost;Data Set;deep learning;deep learning algorithm;Detection;Development;Devices;Diagnosis;Diagnostic;Disease;DNA Sequence Alteration;Epidermal Growth Factor Receptor;Evaluation;Forcep;Future;Grant;Hilar;Histology;Image;Image Analysis;Institution;KRAS2 gene;Location;low dose computed tomography;Lung;lung imaging;lung lesion;Lung nodule;lymph nodes;Malignant neoplasm of lung;Malignant Neoplasms;Mediastinal;Medical Device;Medicine;meetings;microscopic imaging;Modality;Molecular;Molecular Diagnosis;molecular marker;Molecular Profiling;Multicenter Studies;Mutation;Nature;Needles;next generation sequencing;Outcome;participant enrollment;Pathologic;Pathologist;Pathology;Patients;Performance;Peripheral;Pharmacologic Substance;Procedures;prognostic;programmed cell death ligand 1;Research Design;ROC Curve;Sampling;Science;screening program;Site;Specificity;standard of care;System;Testing;Time;Tissues;tool;Training;Translating;treatment planning;Validation

PROJECT_TITLE: A multicenter study in bronchoscopy combining Stimulated Raman Histology with Artificial intelligence for rapid lung cancer detection - The ON-SITE study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-Z(10)B]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The Michigan Institute for Clinical & Health Research (MICHR) catalyzes clinical and translational research (CTR) and advances clinical and translational science (CTS) at the University of Michigan (U-M), throughout the state of Michigan, and nationally. We have transformed CTR at U-M and have been a collaborative partner with university units, Michigan communities, and the Clinical and Translational Science Award Consortium. In the next seven years, MICHR will extend, expand, and engage—we will achieve greater innovation, diversity, efficiency, equity, quality, inclusion, and reach in CTR and develop, demonstrate, and disseminate generalizable CTS innovations.

PI_NAMEs: LUMENG, JULIE C (contact);MARSH, ERICA E

PROGRAM_OFFICER_NAME: LEYVA, FRANCISCO

PROJECT_TERMS: Acceleration;Address;apprenticeship;Automobile Driving;behavioral and social science;Biometry;career;Career Ladders;catalyst;Clinical;Clinical and Translational Science Awards;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;Communities;community academic partnership;community college;community engaged research;community engagement;Community of Practice;community partners;Competence;Computerized Medical Record;cost effectiveness;Data;data modeling;data standards;Development;Dissemination and Implementation;dissemination science;Education;Ensure;Equity;Feedback;Funding;Goals;Grant;Health;Health Services Research;Health system;human centered design;implementation science;improved;Informatics;Infrastructure;innovation;interoperability;Leadership;Medicine;member;Mentors;Michigan;Natural Language Processing;Network-based;novel;Participant;Pathway interactions;patient engagement;Patient Recruitments;Patients;Performance;Persons;Physicians;programs;Protocols documentation;public health emergency;Race;racism;Randomized, Controlled Trials;Research;research and development;Research Training;response;Science;search engine;Services;Site;skill acquisition;skills;social health determinants;social science research;Testing;tool;Training;training opportunity;Training Programs;Translational Research;Translations;Trust;Universities;university student;virtual;Vision;Voice

PROJECT_TITLE: Michigan Institute for Clinical and Health Research (MICHR)


NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The Medical University of South Carolina (MUSC) Digestive Disease Training Program will train a cadre of predoctoral researchers who will drive the future of liver and gastrointestinal (GI)-related biomedical research within three fundamental thematic areas: 1) Inflammation and Fibrosis; 2) Metabolic Disease; and 3) Organ and Tissue Failure.

PI_NAMEs: DUNCAN, STEPHEN A (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Digestive System Disorders;Training Programs

PROJECT_TITLE: Digestive Disease Training Program