NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: RELEVANCE (See instructions): The neural representation of time is implicated in several clinical conditions, including schizophrenia and memory disorders; a deeper understanding of how the brain represents the past could shed new light on this conditions. Moreover, deep artificial neural networks are used in many clinical applications. The new generation of deep networks developed in this project could lead to new applications, including sensory prosthetics for individuals with hearing impairments.

PI_NAMEs: HOWARD, MARC W (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: analytical tool;artificial neural network;Bayesian Modeling;Benchmarking;Brain;Brain region;Cells;Clinical;clinical application;Code;Collaborations;Computer Models;Computers;Data;Data Analyses;Data Set;Development;entorhinal cortex;Event;experimental study;Family;Fire - disasters;Formulation;Generations;Goals;hearing impairment;Hippocampus;Individual;Instruction;Learning;logarithm;Mathematics;Memory;Memory Disorders;Monkeys;neural;Neurons;neurophysiology;nonhuman primate;Pattern;Population;Property;receptive field;Recurrence;recurrent neural network;Schizophrenia;sensory prosthesis;shape analysis;simulation;Stimulus;Testing;theories;Time;timeline;tool;Weight;Work

PROJECT_TITLE: CRCNS: Neural Representations of Time Across Scales in Natural and Artificial Networks


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dissemination and Implementation Research;Health Services;Hypertension;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: EMERGENCY MEDICINE

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE The Translational Research and Implementation Science for Nurses (TRAIN) program is designed to support Doctor of Nursing Practice students from underrepresented minority communities and disadvantaged backgrounds to become experts in translating research into clinical practice. TRAIN provides collaborative, multidisciplinary, multispecialty classroom education and hands-on research experiences mentored by experts in fields of hypertension health disparities.

PI_NAMEs: COHEN, BEVIN ;SOUFFRONT, KIMBERLY T (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Area;Cardiovascular system;career;career networking;Cause of Death;Cessation of life;Chronic;Clinical;clinical center;clinical practice;Clinical Services;Clinical Trials;clinically relevant;cohort;Collaborations;Communication;Communities;Competence;curriculum development;curriculum enhancement;design;didactic education;digital health;disability;disadvantaged background;disadvantaged student;Discipline of Nursing;Disparity;disparity reduction;Education;education research;education resources;Emergency Medicine;Employment;Epidemiology;ethnic disparity;ethnic minority;evidence base;experience;Face;Faculty;Future;Geriatrics;Goals;hands on research;Health;health care delivery;health care settings;health disparity;health equity;Health equity research;Health Policy;Health Sciences;Health Services Research;Health system;Healthcare;Hospitals;Hypertension;hypertension control;hypertension prevention;implementation framework;implementation science;improved;Inequity;innovation;Institution;Instruction;Internal Medicine;Intervention;Leadership;lifestyle intervention;medical schools;medical specialties;Medicine;Mentors;Mentorship;Methods;metropolitan;minority communities;minority student;Mission;mortality;multidisciplinary;National Heart, Lung, and Blood Institute;New York;novel;Nurses;Nursing Education;Nursing Faculty;Nursing Research;nursing skill;Outcome;outcome disparities;Palliative Medicine;Participant;Patients;pharmacologic;Population;population health;Positioning Attribute;practice setting;Prevalence;programs;racial disparity;racial minority;recruit;Reporting;Research;research faculty;Research Methodology;Research Project Grants;Resources;response;Role;School Nursing;Self Assessment;Self Efficacy;skills;Structure;Students;summer program;Training;training opportunity;Training Support;Translating;translational goal;translational health science;translational impact;translational pipeline;Translational Research;Translations;Underrepresented Minority;underrepresented minority student;Underrepresented Students;United States;uptake

PROJECT_TITLE: Translational Research and Implementation Science for Nurses (TRAIN) Program 2.0


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Men who have sex with men and are living with HIV bear the greatest burden of anal cancer. Treatment of the anal cancer precursor, high-grade squamous intraepithelial lesions (HSIL), has proven effective for preventing cancer, and research on how to best implement screening and treatment of HSIL is key to mitigating the risk of anal cancer in low- and middle-income countries (LMIC) such as Nigeria where HIV is highly prevalent. This work will yield a systematic strategy for evaluating HSIL screening and treatment implementation in an HIV care setting and provide generalizable knowledge on context-specific adaptation of a complicated evidence- based intervention in a challenging LMIC environment that will benefit the broader field of implementation science.

PI_NAMEs: ADEBAJO, SYLVIA ;NOWAK, REBECCA G. (contact)

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: Acceleration;Address;Adherence;Adoption;Anus;Cancer Control;cancer prevention;Cancer Prevention Intervention;cancer risk;Caring;Client;Client satisfaction;Clinic;clinical research site;cohort;Communities;Consolidated Framework for Implementation Research;cost effective;Data;design;Development;educational atmosphere;Eligibility Determination;Enrollment;Ensure;Environment;evidence base;evidence based guidelines;Evidence based intervention;Evidence based treatment;experience;Feasibility Studies;follow-up;Friends;General Population;Goals;Group Interviews;HIV;HIV risk;HPV-High Risk;hybrid type 2 trial;implementation barriers;implementation intervention;implementation science;implementation strategy;improved;Infrastructure;insight;International;Interruption;Intervention;Interview;Knowledge;Language;Learning;low and middle-income countries;Maintenance;Malignant neoplasm of anus;Malignant Neoplasms;men who have sex with men;Methods;Modeling;multidisciplinary;Neoplasms;Nigeria;Outcome;Participant;Patients;Persons;Physicians;Policy Maker;Population;Prevalence;prevent;Prevention;primary outcome;prophylactic;Prospective Studies;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Risk Factors;risk mitigation;scale up;screening;Screening for cancer;screening guidelines;Screening Result;secondary outcome;Series;Site;Societies;Squamous intraepithelial lesion;Structure;Testing;Time;tool;Training;United States;uptake;Virus;Work

PROJECT_TITLE: Integrated Model for the Prevention of Anal Cancer using screen and Treat for HSIL (IMPACT)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Methamphetamine;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CAMBRIDGE

ORG_NAME: CLEAR SCIENTIFIC, LLC

ORG_STATE: MA

PHR: PROJECT NARRATIVE Methamphetamine is the fastest growing drug of abuse in the U.S., representing 800,000 emergency department visits and nearly 35,000 deaths annually. The proposed project addresses the urgent need for a safe, rapidly acting therapeutic to treat methamphetamine overdose. Such an antidote would save lives, improve patient outcomes, and relieve burden on already strained hospital resources.

PI_NAMEs: LI, XINHUA  (contact)

PROGRAM_OFFICER_NAME: DRGONOVA, JANA

PROJECT_TERMS: Acceleration;Accident and Emergency department;Achievement;Acute;Address;Agreement;Antidotes;Binding;Biodistribution;Biological;Biological Markers;Blood;Canis familiaris;Central Nervous System;Cessation of life;Chemistry;clinical development;Clinical Research;Clinical Trials;Clinical Trials Design;Complex;Cross-Over Studies;Dose;Double-Blind Method;Drug Kinetics;drug of abuse;Drug Prescriptions;Drug Stability;Drug usage;efficacy evaluation;Emergency department visit;Excision;Filtration;first-in-human;Formulation;good laboratory practice;Good Manufacturing Process;Guidelines;Half-Life;Hospitals;Human;Human body;improved;In Vitro;in vivo;Individual;International;Intoxication;Intravenous;intravenous injection;Investigational New Drug Application;Kidney;Label;Ligands;manufacture;manufacturing process;Marketing;meetings;Metabolism;Methamphetamine;Methamphetamine overdose;Methamphetamine use disorder;nonhuman primate;novel strategies;open label;Outcome;Patient-Focused Outcomes;Pharmaceutical Preparations;Pharmacology;Pharmacology and Toxicology;Pharmacology Study;Phase;Phase Ia Trial;Phase Ib Clinical Trial;Phase Ib Trial;phase III trial;Placebo Control;placebo controlled study;Plasma;Pregnant Women;Preparation;Probability;Production;programs;Randomized;Rattus;receptor;Recommendation;reproductive toxicity;Resources;response;Rodent;Safety;Sales;Saline;scale up;Site;small molecule;success;Therapeutic;Therapeutic Agents;Time;Toxic effect;Toxicology;United States Food and Drug Administration;Urine;Vial device;Visit

PROJECT_TITLE: Clinical Development of a Therapeutic Agent for Rapid Reversal of Methamphetamine Intoxication

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Current research suggests that mobile health interventions have been successful in leading to behavior change but African American smokers have not been well represented in mobile health intervention studies for smoking cessation despite having lower success with cessation when compared with other racial groups. This project develops the prototype of a mobile health app with features that are culturally adapted for African American smokers, which may lead to increased uptake, aimed at improving successful smoking cessation in this underserved population.

PI_NAMEs: ENYIOHA, CHINEME IJEOMA (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Adult;Advisory Committees;African American;African American population;Area;behavior change;Behavioral Model;career;Cellular Phone;Cessation of life;Communication;Computer software;cost;Counseling;design;Development;Diabetes Mellitus;Disease;Documentation;Effectiveness;Elements;evidence base;experience;Experimental Designs;experimental study;Feedback;Flowcharts;Focus Groups;formative assessment;Future;General Population;Goals;Health;health care availability;health equity;Health Technology;Healthcare;Image;improved;Intervention;Intervention Studies;Interview;K-Series Research Career Programs;Knowledge;Literature;Maps;Mentors;Methodology;mHealth;mhealth interventions;Mobile Health Application;Motivation;National Institute of Drug Abuse;nicotine cessation;Nicotine Dependence;novel;Obesity;Participant;Patients;Pharmacotherapy;phase 3 testing;preference;Preparation;Process;prototype;Race;racial population;randomized trial;Reaction;Recovery;Reduce health disparities;Research;Schedule;Science;Scientist;Series;skills;smartphone application;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;social;Specific qualifier value;Structure;Substance Use Disorder;substance use treatment;success;System;tailored messaging;Testing;text searching;therapy development;Tobacco use;Training;Transportation;trial comparing;Underserved Population;United States National Institutes of Health;uptake;usability;user centered design;Work

PROJECT_TITLE: Development of a prototype for a mobile health intervention for smoking cessation with features culturally adapted for African American smokers

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: AUSTIN

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE  The descending auditory efferent pathway may be involved in supra-threshold hearing, but a comprehensive understanding of how the efferent system develops in humans is lacking. The proposed work will investigate the development of the temporal aspects of efferent mechanisms in children. It is clinically and scientifically relevant, as the knowledge gained can be used to develop objective tests for assessing auditory function, guide intervention efforts and may be applied for designing hearing devices.

PI_NAMEs: MISHRA, SRIKANTA  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: 12 year old;Acoustics;Adult;Affect;Age;Algorithms;Audiology;Auditory;Auditory Perception;auditory processing;Auditory system;Biological Assay;Brain Stem;Child;Childhood;Clinical;cochlear synaptopathy;Code;Communication;Complex;Contralateral;Data;design;Development;developmental plasticity;Device Designs;Efferent Pathways;Environment;Exhibits;experience;Feedback;Frequencies;Goals;Hearing;Hearing Aids;Human;improved;infancy;innovation;insight;Intervention;Ipsilateral;Knowledge;Language Development;Life;Measurement;Measures;Medial;Modeling;neural;Noise;noise exposure;Noise-Induced Hearing Loss;novel;Outcome;Outcome Study;Peripheral;Play;Population;Predisposition;Principal Investigator;Public Health;Research;response;Role;signal processing;Signal Transduction;sound;Speech;Speech Perception;Stimulus;System;Techniques;Testing;theories;Time;Work

PROJECT_TITLE: Development of medial efferent mechanisms in children

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE: This ACE GEARs Network application seeks to establish a Network for the study of gene- environment interaction in ASD and health outcomes among people with ASD. The “Combining advances in Genomics and Environmental science to accelerate Actionable Research and practice in ASD” (GEARs) Network will create infrastructure and processes to harmonize data from 18 sites to investigate gene-environment interaction at scale. These population studies will be supported by laboratory-based experimental studies using 3D in vitro brain organoids and translation and dissemination efforts.

PI_NAMEs: LADD-ACOSTA, CHRISTINE ;VOLK, HEATHER E (contact)

PROGRAM_OFFICER_NAME: LAWLER, CINDY P

PROJECT_TERMS: 16p11.2;3-Dimensional;Acceleration;Address;Air Pollution;autism community;autism spectrum disorder;Biological;Biological Models;Brain;Cell Line;Characteristics;cohort;Collaborations;Communication;community partners;comorbidity;Data Collection;data harmonization;design;Development;Diagnosis;Disease;disorder risk;Environment;Environmental Impact;Environmental Risk Factor;Environmental Science;Etiology;Evaluation;experience;Experimental Models;experimental study;Family;Folic Acid;Fostering;Future;gastrointestinal symptom;gene environment interaction;Gene Mutation;Genetic;Genetic Risk;genetic variant;genome sciences;genome wide association study;genome-wide;Genomic approach;Genomics;Health;Heavy Metals;Heritability;high risk;improved;In Vitro;in vitro testing;Individual;individuals with autism spectrum disorder;induced pluripotent stem cell;Infection;Inflammation;Infrastructure;Investigation;Laboratories;Manuscripts;Measures;Mental Health;Modeling;National Human Genome Research Institute;Network Infrastructure;Neurodevelopmental Disorder;neuroinflammation;neurophysiology;novel;Obesity;Organoids;Outcome;outreach;Pathway Analysis;Phenotype;phenotypic data;physical conditioning;Population;Population Study;prenatal;Process;psychogenetics;Public Health;Publishing;rare variant;repetitive behavior;Research;Research Personnel;Resources;Risk;Sample Size;Science;Severities;Shapes;Site;Sleep;social communication;Social Interaction;Statistical Methods;Structure;success;synaptogenesis;Testing;Time;trait;Translating;translational approach;Translations;transmission process;Vitamins;Work

PROJECT_TITLE: GEARs Combining advances in Genomics and Environmental science to accelerate Actionable Research and practice in ASD


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Nanotechnology;Osteoporosis;Regenerative Medicine

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: This renewal grant application represents a deepened extension of the current grant (DE25681) focusing on the bone-enhancing effects of microRNA (miR)-335-5p, first identified and characterized in our laboratory. Our recent studies have demonstrated that miR-335-5p has important dual-effects: inhibiting osteoclastic bone resorption and promoting osteoblastic bone formation, therefore miR-335-5p is a potent pharmaceutic agent for treating osteoporosis and its related bone disorders, where the balance between resorption and formation is disturbed. Applying our recently generated miR-335-5p gene knockout and overexpressing transgenic mouse lines our newly developed, cutting-edge targeted nanoparticle system will be used for the first time to precisely deliver miR-335-5p to the distinct cell types to modulate both bone anabolic and metabolic pahways, which will allow this translational study to shift the paradigm in understanding, treating and ultimately curing osteoporosis and its related bone disorders.

PI_NAMEs: CHEN, JAKE JINKUN (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: 3' Untranslated Regions;Age;American;Applications Grants;Award;Awards and Prizes;Binding;Biocompatible Materials;Biological;Biological Assay;Biology;Biomechanics;Biomedical Engineering;bisphosphonate;bone;Bone callus;Bone Density;Bone Diseases;bone fracture repair;bone healing;bone metabolism;Bone Regeneration;Bone Resorption;cathepsin K;cell type;Cells;Cellular biology;Collaborations;cost;Crossbreeding;Data;Disadvantaged;Disease;disease model;Dose;Drug Delivery Systems;Drug Targeting;Elements;Epidemic;Equilibrium;experience;Experimental Pathology;experimental study;Femoral Fractures;Foundations;Frequencies;Functional disorder;gain of function;Genes;genetic manipulation;Genetic Markers;Grant;Hand;Immunoglobulins;improved;Individual;innovation;Intervention;knockout gene;Laboratories;loss of function;Luciferases;Mature Bone;member;men;Metabolic;MicroRNAs;MMP9 gene;Molecular;Molecular Biology;Mus;Mutation;nanoparticle;New Jersey;novel;null mutation;Osteoblasts;Osteoclasts;Osteogenesis;osteogenic;Osteoporosis;osteoporosis with pathological fracture;osteoporotic bone;Ovariectomy;overexpression;Paper;Pathway interactions;patient prognosis;Peer Review;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Probability;Process;Progress Reports;Property;Proteins;PTH gene;Publishing;regenerative;Reporter;Reporting;Research;Research Personnel;Research Project Grants;Risk;Role;Scientist;Selective Estrogen Receptor Modulators;side effect;Signal Pathway;Site;skills;System;Technology;Therapeutic Effect;therapeutic miRNA;Time;Transgenic Mice;translational study;United States National Institutes of Health;Untranslated RNA;Woman;wound

PROJECT_TITLE: Roles of Noncoding RNA in Bone Regeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Networking and Information Technology R&D (NITRD)

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative High-throughput spatial technologies are poised to become ubiquitous and transformative in precision medicine, including the diagnosis, prognosis, and therapeutic response in disease. However, researchers who aim to appropriately interpret these data face new challenges with increasingly complex data and experimental designs, such how to harmonize and jointly analyze multiple spatial samples simultaneously with images and omics data, or how to identify spatial-dependent difference across experimental groups, such as healthy and disease states, each group with multiple donors or adjacent tissue sections. Our long-term goal is to address these questions by developing statistically-rigorous computational tools for spatial and long-read technologies with increased statistical power to detect spatial domains or differences in spatial-dependent gene expression in large atlas-scale spatially-resolved transcriptomics data.

PI_NAMEs: HICKS, STEPHANIE CARINNE (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Alleles;Atlases;Biological;cell type;Cells;complex data;Computer software;computerized tools;Computing Methodologies;Data;Data Analyses;Data Set;Diagnosis;Discipline;Disease;Environmental Health;experience;Experimental Designs;experimental group;Face;Gene Expression;genomic data;Goals;Health;Human;Image;improved;Individual;Knowledge;Malignant Neoplasms;Methods;mHealth;Molecular;multidimensional data;Neurodegenerative Disorders;open source;precision medicine;Prevention;Prognosis;programs;Research;Research Personnel;RNA Splicing;Sampling;Specificity;Technology;Tissues;tool;transcriptome sequencing;transcriptomics;treatment response;Variant;Work

PROJECT_TITLE: Computational Methods for Emerging Spatially-resolved Transcriptomics with Multiple Samples

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Despite South Africa having the largest antiretroviral treatment program in the world HIV incidence remains high and epidemic control will not be reached without an effective complementary prevention program. The daily provision of combination antiretroviral medication to HIV negative individuals at substantial risk of HIV infection has proven highly effective at preventing HIV infection (known as ‘pre-exposure prophylaxis’ - PreP), but even where PrEP is available uptake amongst key populations has remained sub optimal. The behavioral economic framework provides a unique lens to examine why at-risk individuals are not initiating and persisting on PrEP and in doing so will provide evidence to develop alternative, low cost approaches to encourage optimal decision making around PrEP use.

PI_NAMEs: LONG, LAWRENCE CAMDON (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Africa;AIDS prevention;Anti-Retroviral Agents;antiretroviral therapy;Applications Grants;Behavior;behavior change;Behavior Therapy;Behavioral;behavioral economics;Behavioral Sciences;Belief;Boston;career;career development;Cognitive;cohort;cost;Data;Decision Making;design;Development;Development Plans;Effectiveness;Effectiveness of Interventions;Eligibility Determination;epidemic response;Failure;Focus Groups;Funding;Future;Goals;Government;Health;Health behavior;health care service;health care service utilization;health goals;Health Personnel;high risk;high risk men;high risk population;HIV;HIV Infections;HIV risk;HIV Seronegativity;Human;Human immunodeficiency virus test;improved;Incidence;Individual;Infection;infection risk;informant;innovation;Intervention;Interview;Knowledge;Learning;lens;Medical Records;men who have sex with men;Mentored Research Scientist Development Award;Mentorship;Methods;novel;Participant;Patients;Pharmaceutical Preparations;Pilot Projects;Play;Population;pre-exposure prophylaxis;predictive modeling;prevent;Prevention;Prevention program;Preventive therapy;Process;professor;programs;Psychology;Qualitative Research;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;Reporting;Research;Research Assistant;Research Methodology;Research Personnel;Risk;Risk Behaviors;Risk Reduction;Role;Service provision;Site;skills;social health determinants;Socioeconomic Status;South Africa;South African;structural determinants;Surveys;Testing;theories;tool;Training;Training Activity;treatment program;Universities;uptake;Vulnerable Populations;Work

PROJECT_TITLE: Using behavioral economics to improve the uptake of and persistence on pre-exposure prophylaxis in men who have sex with men to prevent HIV infection

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Disability Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative The ability of the adult brain to undergo plasticity is limited than that observed in young, but some sensory deprivation paradigms can effectively produce plasticity in the adult primary visual cortex (V1). Here we will examine how visual and auditory deprivation differentially alters adult V1 to enhance either contextual or visual inputs, respectively. Our results will not only elucidate the mechanisms of adult cortical plasticity, but will also provide means to selectively enhance specific functionality of the adult V1.

PI_NAMEs: LEE, HEY-KYOUNG  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Adolescent;Adult;Area;area striata;Auditory area;auditory deprivation;awake;braille;Brain;Chemosensitization;Darkness;Data;deaf;Disinhibition;Excitatory Synapse;experience;extrastriate visual cortex;Feedback;Feeding Patterns;first responder;Frequencies;Head;Image;Individual;Interneurons;Investigation;Lateral;Mediating;Methods;Modality;multisensory;Mus;Neurons;novel;Ocular Dominance;optogenetics;Parvalbumins;Pattern;Play;postnatal development;postsynaptic;Reading;recruit;Reporting;resilience;Rodent;Role;Sensory;sensory cortex;Sensory Deprivation;Somatostatin;Speech;Synapses;Testing;Thalamic structure;transmission process;two-photon;Visual;Visual Cortex;visual deprivation;visual information;visual plasticity;visual processing;Visually Impaired Persons;Work

PROJECT_TITLE: Global Synpatic Plasticity Mechanisms in Visual Cortex

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Our proposal seeks to improve HIV outcomes among pregnant and postpartum women living with HIV and their infants in sub-Saharan Africa. We will develop a novel risk calculator to better identify pregnant women who should be the highest priority for intervention to prevent treatment failure and dropouts from HIV care. Next, we will engage women and lay health workers in adapting a promising evidence-based intervention (Problem Management Plus) to address psychosocial stressors and reduce treatment failure and loss to follow up and then pilot the intervention to test its acceptability, feasibility, and preliminary efficacy. This study will contribute to the overall goal of achieving optimal health outcomes for women living with HIV and their families in sub-Saharan Africa.

PI_NAMEs: ABUOGI, LISA LYNN (contact);ONONO, MARICIANAH ATIENO;TURAN, JANET M.

PROJECT_TERMS: adaptive intervention;Address;Adherence;Africa South of the Sahara;antiretroviral therapy;Behavioral;Caring;Cellular Phone;Child;Clinic Visits;Clinical;Cluster randomized trial;Collaborations;Communities;Complex;Data;design;Distress;Dropout;effective intervention;effectiveness/implementation trial;Ensure;Evidence based intervention;experience;Face;Failure;Family;follow-up;Funding;Goals;Health;health goals;high risk;HIV;HIV Infections;human centered design;Hybrids;improved;Infant;Intervention;intimate partner violence;Kenya;Longitudinal Studies;male;Maternal and Child Health;Maternal Health;Mental Depression;Mental Health;Mentors;Methods;mHealth;Minor;Modality;Mother-to-child HIV transmission;Mothers;Newly Diagnosed;novel;Outcome;Performance;Persons;pilot test;Population;Postpartum Period;Postpartum Women;Prediction of Response to Therapy;predictive tools;Pregnancy;Pregnant Women;prevent;primary outcome;problem solving therapy;programs;Psyche structure;psychosocial;Psychosocial Assessment and Care;Psychosocial Factor;psychosocial stressors;Randomized;Research;Resource-limited setting;Resources;Risk;Risk Factors;risk stratification;Sampling;satisfaction;scale up;social stigma;sociodemographics;Specialist;standard of care;Subgroup;Testing;Text Messaging;therapy adherence;three-arm study;tool;Treatment Failure;Treatment outcome;Vertical Disease Transmission;Violence;Viral;Viral Load result;Visit;visit adherence;Woman;women's outcomes;Work

PROJECT_TITLE: Piloting risk stratification and tailored interventions with pregnant and postpartum women with HIV in Kenya to prevent disengagement from care and viral failure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-T(02)]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Relevance Statement The two emerging ‘hallmarks of cancer’ are deregulating cellular energetics and avoiding immune disruption. By integrating cell metabolism and immune function, the principal investigator has consistently made important contributions to our understanding of the fundamental mechanisms of immunometabolism and its impact on cancer, especially in dissecting the interplay between immune signaling and metabolism and synthesizing systems immunology with immunometabolism. The project described in this application will provide an integrative view of immunometabolism, and how it relates to cancer and cancer therapy, with an excellent path to bench-to- bedside translation and clinical development for innovative therapeutics.

PI_NAMEs: CHI, HONGBO  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: adaptive immune response;Algorithms;Area;bench-to-bedside translation;Biological Process;cancer immunotherapy;cancer therapy;Cells;Cellular Metabolic Process;clinical development;clinical translation;CRISPR screen;Dendritic Cells;Development;experience;Foundations;FRAP1 gene;Goals;Heterogeneity;Homeostasis;human disease;Immune;immune function;Immune signaling;Immunity;Immunology;Immunooncology;improved;in vivo;Inflammation;innovation;insight;interdisciplinary approach;Link;Malignant Childhood Neoplasm;Malignant Neoplasms;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;novel;Nutrient;Pathway interactions;Positioning Attribute;pre-clinical;Principal Investigator;Process;Program Description;programs;Proteomics;rapid growth;refractory cancer;Research;Signal Transduction;stemness;System;Systems Biology;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Tissues;Tumor Immunity;tumor microenvironment;Work

PROJECT_TITLE: Integrating systems immunology with immunometabolism and cancer immunity


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE Drinking in adolescence is common, but the persistent consequences of excessive drinking during adolescence are not well understood. The NADIA Administrative Core coordinates the efforts of eight Research Components and one Scientific Core to determine the consequences of binge-like adolescent alcohol exposure on adult brain physiology, structure, chemistry, maturation and behavioral indices of affect, motivation and/or cognition. This information will be important to guide public health policy and develop better tools for the prevention of risky behavior in adolescents.

PI_NAMEs: CREWS, FULTON T (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent alcohol exposure;adolescent binge drinking;adolescent health;Adult;Affect;alcohol consequences;Alcohol consumption;alcohol effect;alcohol exposure;alcohol research;alcohol sensitivity;Alcohols;Animal Model;anxiety-like behavior;Astrocytes;Behavior;Behavioral;behavioral outcome;Brain;Brain Pathology;Chemistry;Choline O-Acetyltransferase;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;Cognitive;Collaborations;Communication;Communities;Complex;Data;data integration;Decision Making;Development;drinking;Ensure;Epigenetic Process;epigenetic regulation;Ethanol;Evaluation;Experimental Designs;Extinction;Faculty;flexibility;Funding;gene editing technology;Gene Expression Regulation;General Population;Genes;Goals;Health Policy;Heavy Drinking;Human;Impulsivity;indexing;Individual;Joints;Leadership;Link;Measures;meetings;Microglia;Molecular;Motivation;National Institute on Alcohol Abuse and Alcoholism;neural;Neurobiology;neurochemistry;neurodevelopment;Neuroimmune;neuroinflammation;Neurons;neurotransmission;Neurotransmitters;new technology;novel;Organization administrative structures;Pathology;Pathway interactions;pharmacologic;Physiological;Physiology;prevent;Prevention;Procedures;Productivity;Progress Reports;psychologic;Psychopathology;Public Health;Publications;Recommendation;repository;Research;Research Design;Research Personnel;Research Support;Review Literature;Risk Behaviors;Role;sex;Sleep disturbances;Structure;symposium;synergism;therapeutic development;Therapeutic Intervention;tool;translational goal;translational potential;translational study;Translations;underage drinking;United States National Institutes of Health;Writing

PROJECT_TITLE: 1/1 NADIA U24 Administrative Core


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD);Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: The second phase of NIH Common Fund 4D Nucleome Network Organizational Hub Narrative The second phase of the 4DN program will study chromatin dynamics in live cells, complex tissues, and disease conditions. The 4DN Organizational Hub is proposed to: (1) coordinate and integrate the efforts of all the funded projects, (2) build an efficient consortium infrastructure to serve as a center for the collaborative efforts, and (3) provide the 4DN web portal as a central resource gateway to access all the 4DN-Network generated tools, policies, guidelines, protocols, reagents, and cell lines.

PI_NAMEs: ZHONG, SHENG  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: 3-Dimensional;Address;American;Architecture;cell bank;Cell Line;Cell Nucleus;cell repository;Cells;Cellular biology;Chromatin;Collaborations;Collection;Communication;Communities;Complex;computerized tools;Credentialing;Data;data exchange;data integration;data portal;data repository;Decision Making;design;Disease;Education and Outreach;Educational Materials;Educational workshop;Ensure;Feedback;Feeds;Funding;Generations;Goals;Group Meetings;Guidelines;Health;Human Genetics;Imaging Device;improved;Infrastructure;interoperability;Joints;Libraries;life span;Manuscripts;Maps;meetings;Methods;migration;Modeling;news;Newsletter;Nuclear;Organizational Efficiency;organizational structure;outreach;Paper;Phase;Policies;portability;Printing;Problem Solving;Process;programs;Protocols documentation;Reagent;Reporting;Research;Resource Sharing;Resources;Schedule;social media;Societies;software repository;statistics;Structure;success;symposium;synergism;Technology;Teleconferences;Tissues;tool;United States National Institutes of Health;Update;user-friendly;Visualization;web portal;web site;webinar;wiki;working group

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(50)R]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Cancer researchers grounded in the field of pathology are critically needed if basic insights into the pathobiology of cancer are to translate into improved patient treatment and better patient outcomes. To address this need, the Oncopathology Training Program at Brigham and Women’s Hospital will provide physicians trained in the field of pathology with the comprehensive mentored research and didactic training experience that is needed to prepare them for careers as cancer investigators. We seek to train future leaders in pathology who not only provide new insights into the cause of cancer, but also bring innovative approaches to the diagnosis and treatment of cancer to the clinic, to the benefit of cancer patients and their families.

PI_NAMEs: ASTER, JON C. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Training Programs

PROJECT_TITLE: Oncopathology Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Clinical Research;Pediatric

ORG_CITY: AMES

ORG_NAME: PARAMETRIC STUDIO, INC.

ORG_STATE: IA

PHR: Project Narrative: The U.S. has more health science STEM jobs available than qualified workers to fill them and lags other OECD nations in math and science, with major achievement gaps and STEM workforce under- representation among women and students of color. With its successful Phase I SBIR results, Parametric Studio Inc (PSI) proved the functionality, feasibility, and usability of MiMICRE, a game-based project platform that uses collaborative bioengineering projects to help address STEM deficiencies, promote 21st-century skills, and reduce under-representation in the future health science and STEM workforce. The PSI team now proposes a Phase II project that will allow the PSI team to complete full development of MiMICRE with all fully tested/validated STEM- related features and capabilities needed for commercial investment and deployment.

PI_NAMEs: WHITMER, CHRISTOPHER ELDON (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: 3D Print;Achievement;Address;Adoption;Attitude;Biological Sciences;Biomedical Engineering;Code;Collaborations;college;Color;commercialization;Communities;Competence;Computer software;cost;COVID-19 pandemic;COVID-19 pandemic effects;Critical Thinking;Custom;Degree program;design;Development;Devices;educational atmosphere;Educational Curriculum;Elements;Employment;Engineering;Environment;essays;experience;Future;Game Based Learning;Goals;Health Sciences;Healthcare;high school;High School Student;improved;Industry;innovation;Instruction;instructor;instrumentation;interest;Investments;Knowledge;Lead;Learning;learning materials;Libraries;Link;Low income;Marketing;mathematical difficulties;Mathematics;mathematics content;Medical;mimetics;Modeling;novel strategies;Occupations;Operating System;Outcome;Performance;Phase;pilot test;Private Sector;Problem Solving;programs;project-based learning;prototype;Qualifying;recruit;Research;response;Science;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;simulation;simulation game;skills;Small Business Innovation Research Grant;STEM career;STEM field;student participation;Students;success;Surveys;System;teacher;Test Result;Testing;Time;tool;Training;Training and Education;undergraduate student;Underrepresented Populations;usability;Validation;virtual;Woman;Work

PROJECT_TITLE: A Virtual Project-Based Learning Sandbox for Mimetics and Medically Inspired Classroom Engineering (MiMICRE)


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: WILMINGTON

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Approximately one million babies die annually in low and middle-income countries due to a brain injury caused by inadequate blood flow and oxygen delivery to the neonatal brain, a condition known as hypoxic ischemic encephalopathy. “Milking” the umbilical cord, a method used to transfer blood from the placenta into the baby before the umbilical cord is clamped, may result in decreased death and brain injury due to lack of blood flow to the brain. This intervention may prevent some conditions or disabilities that have lifelong consequences.

PI_NAMEs: AGHAI, ZUBAIR H (contact);DHADED, SANGAPPA M;KATHERIA, ANUP C

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: 2 year old;Affect;American;Anemia;Animals;Attention;autism spectrum disorder;Birth;Blood;Blood flow;Blood Pressure;Blood Volume;Brain;brain abnormalities;Brain Injuries;Breathing;Cardiovascular system;Cerebral Palsy;Cessation of life;Closure by clamp;college;Controlled Study;cost;Country;Depressed mood;design;Development;disability;Discipline of obstetrics;Enrollment;Ensure;fetal blood;Guidelines;Gynecology;Heart;Heart Rate;Hospitalization;Hospitals;Impairment;implementation cost;improved;Incidence;Income;India;Individual;Infant;International;Intervention;intervention cost;Knowledge;Left;low and middle-income countries;Lung;Magnetic Resonance Imaging;Methods;Milk;mortality;natural hypothermia;neonatal brain;neonatal hypoxic-ischemic brain injury;neonate;Neurodevelopmental Impairment;neuroprotection;Newborn Infant;Outcome;Oxygen;Perfusion;Placenta;prevent;primary outcome;Process;Provider;Pump;Randomized;randomized, clinical trials;Recommendation;Resuscitation;Site;standard of care;Survivors;Term Birth;Testing;Therapeutic;Time;Training;Transfusion;treatment effect;Umbilical Cord Blood;Umbilical cord structure;Work;World Health Organization

PROJECT_TITLE: A Cluster Randomized Clinical Trial of Umbilical Cord Milking to Improve Short and Long-term Outcomes in Neonates Who are Non-Vigorous at Birth


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative A major advance in using immunology to treat disease has been giving patients T cells that have been expanded in the laboratory and are specific for an antigen associated with the patient's medical condition, using either naturally antigen-specific T cells or using gene transfer to make the T cells specific for a particular antigen. Not all patients benefit from these therapies partly because the administered T cells must also have the right machinery to go to the site where they are needed. Antigen displayed on the lining of the local blood vessels normally can direct T cell homing to the right sites and, in this application, we will determine if the same process can also direct homing of expanded T cells, and if so, how to make it more efficient.

PI_NAMEs: MANES, THOMAS DAVID;POBER, JORDAN S (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Immunotherapy;Adoptive Transfer;Affect;allograft rejection;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Autoimmunity;autoinflammatory diseases;Blood Vessels;cancer immunotherapy;CD8B1 gene;Cell Adhesion Molecules;Cell Line;Cell surface;Cells;chemokine;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials;Cross Presentation;cytokine;Cytoplasm;Disease;Dual-role transvestism;effector T cell;Endothelial Cells;Endothelium;experimental study;Gene Transfer;genetic manipulation;Homing;Human;human migration;immunodeficient mouse model;Immunology;Implant;In Vitro;in vitro Model;in vivo;in vivo Model;Infection;Infusion procedures;Interleukin-2;Knowledge;Laboratories;Ligands;Mediating;Medical;Memory;migration;Modeling;Molecular;monolayer;Mus;Organelles;Patients;Pattern;Peptide/MHC Complex;Peripheral;Phenotype;Play;Population;Process;Production;receptor;recruit;Regulatory T-Lymphocyte;response;Role;Signal Induction;Signal Transduction;Site;species difference;success;Surface;T cell differentiation;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Tissues;Treatment Efficacy;Tubular formation;tumor;Vascular Endothelial Cell;Viral Cancer;Virus Diseases

PROJECT_TITLE: Mechanisms and consequences of antigen-dependent T cell homing for adoptive immunotherapies

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SALT LAKE CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Antibiotic overuse at hospital discharge is common, costly, and harmful. Despite evidence that discharge- specific stewardship interventions can improve antibiotic prescribing, these interventions are not feasible for most hospitals. To address this need, we will conduct a 40-hospital cluster randomized trial to evaluate the effectiveness and understand factors influencing implementation of the Reducing Overuse of Antibiotics at Discharge (ROAD) Home intervention, a participatory intervention that helps hospitals select strategies to improve their discharge antibiotic prescribing based on their needs, context, and capacity.

PI_NAMEs: SZYMCZAK, JULIA E.;VAUGHN, VALERIE MICHELE (contact)

PROGRAM_OFFICER_NAME: MILLER, MELISSA

PROJECT_TITLE: Reducing Overuse of Antibiotics at Discharge: The ROAD Home Trial

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Osteogenesis Imperfecta;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative  The goal of this application is to understand the different types of skeletal stem cells in the skull vs. long bones, and how they contribute to bone formation and repair. We will also study the effects of Wnt1 signaling and anti-sclerostin therapy on this population and during repair.

PI_NAMEs: LEE, BRENDAN  (contact);PARK, DONGSU

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Adolescent;Adult;Antibodies;Antibody Therapy;Biological Assay;bone;bone healing;Bone Injury;Bone Regeneration;bone repair;Calvaria;Cartilage;CCR5 gene;Cell Differentiation process;Cell Transplantation;Cells;Cephalic;Characteristics;craniofacial;craniofacial bone;cranium;Data;Defect;Development;early onset;Environment;Flow Cytometry;Gene Expression Profile;Generations;Genetic Models;Goals;healing;Homeostasis;Human;Human Genetics;In Vitro;in vivo;Injury;injury and repair;intravital imaging;KDR gene;Label;Ligands;long bone;Maintenance;Mediating;Mesenchymal;migration;Modeling;Molecular;Morphology;mouse genetics;mouse model;Mus;Mutation;Natural regeneration;Neural Crest;novel;Osteoblasts;Osteogenesis;Osteogenesis Imperfecta;Osteoporosis;Patients;Periosteal Cell;Periosteum;Phenotype;Play;Population;Population Dynamics;postnatal;Proliferating;Regulation;repaired;Reporting;Research Proposals;response;Role;Signal Transduction;single-cell RNA sequencing;Site;Skeletal bone;skeletal stem cell;skeletal tissue;Source;Specific qualifier value;Specificity;stem cell biomarkers;stem cell function;stem cell migration;stem cell model;stem cell population;stem cells;Surgical sutures;Testing;tibia;Tissues;Transplantation;TSC1 gene;WNT Signaling Pathway;WNT1 gene

PROJECT_TITLE: WNT1 Function in Stem Cells in Osteogenesis Imperfecta and Craniofacial-Skeletal Tissues

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Single-cell genomics has recently advanced the lineage tracing field, enabling fine-resolution tracking of individual cells. Unfortunately, these methods have limitations in their reliance upon multiple experimental interventions for cell labeling, causing bifurcation events to be missed, and limitations due to transgene silencing of the components of the single-cell lineage tracing system, making single-cell lineage tracing inapplicable in valuable model systems such as pluripotent cell differentiation. My preliminary results indicate that a CRISPR- Cas12a-guided cytidine deaminase can function as an editor to accrue mutations constantly over time to record lineage, and the application of this editing will create robust lineage tracing systems that can mitigate transgene silencing and dispense with the need for multiple rounds of cell labeling.

PI_NAMEs: VANHORN, SADIE M (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Address;Animal Model;Area;Bar Codes;base;base editing;base editor;Biological Models;Biological Process;Cell Differentiation process;Cell Line;Cell Lineage;Cell model;Cell Reprogramming;Cell Transplantation;cell type;Cells;Cellular biology;Characteristics;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Cytidine;Cytidine Deaminase;Data;Development;discrete time;Disease;disease model;Event;Gene Components;Gene Expression;Gene Silencing;Genes;Genome;genome editor;Heritability;In Vitro;Individual;induced pluripotent stem cell;insight;Intervention;invention;Kidney;Label;Lentivirus;Methods;Modeling;Mutate;Mutation;new technology;novel;Organoids;Outcome;Plasmids;Population;protein expression;Protocols documentation;reconstruction;Resolution;Resources;single cell genomics;single-cell RNA sequencing;synthetic construct;System;Techniques;Technology;Thymine;Time;tool;Transcript;Transgenes;Transgenic Organisms;Validation;Viral;Virus;Work;Writing

PROJECT_TITLE: Developing mutable barcodes for high-resolution single-cell lineage tracing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: ROCHESTER

ORG_NAME: ROCHESTER INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Enabling Rational Design of Drug Targeting Protein-Protein Interactions with Physics- based Computational Modeling. A network of protein-protein interactions (PPIs) is at the core of cells’ and viruses’ abilities to perform their functions and regulate their life-cycles. Developing drugs to modulate these interactions will result in new classes of antivirals and antibiotics, and new therapies to fight diseases characterized by an imbalance in the interaction network, such as some forms of cancer. We propose to use physics-based simulations to develop key missing computational tools that will enable the rational designing of these new classes of antiviral and antibiotic drugs and cancer therapies.

PI_NAMEs: BRINI, EMILIANO  (contact)

PROGRAM_OFFICER_NAME: NANDA, JAGPREET SINGH

PROJECT_TERMS: Affect;Affinity;Anti-viral Agents;Antibiotic Therapy;Antibiotics;Artificial Intelligence;Aspirin;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Beds;Behavior;Benchmarking;Binding;Binding Sites;biological systems;Cancer Etiology;cancer therapy;cancer type;Cells;Complex;Computer Models;computer studies;computerized tools;COVID-19;Data;Databases;design;Development;Diffusion;dimer;Disease;DNA Sequence Alteration;Drug Design;drug discovery;Drug Screening;Drug Targeting;drug-like compound;Equus caballus;experimental study;fighting;Free Energy;Future;Genetic Diseases;Genetic Predisposition to Disease;Grant;Induced Mutation;Infection;Infection prevention;Inflammation;inhibitor;interest;Knowledge;Life Cycle Stages;Ligands;Machine Learning;Malignant Neoplasms;Measures;Methods;Modeling;Molecular;Molecular Conformation;molecular dynamics;Mutation;next generation;nirmatrelvir;novel antibiotic class;novel drug class;novel therapeutics;Paxlovid;Peptides;Pharmaceutical Preparations;Pharmacotherapy;Physics;Property;Protein Engineering;protein folding;protein protein interaction;protein structure prediction;Proteins;Protocols documentation;Race;rational design;Research;response;Role;Sampling;Series;simulation;small molecule;Speed;success;System;Techniques;Testing;tool;Training;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: Enabling Rational Design of Drug Targeting Protein-Protein Interactions with Physics-based Computational Modeling


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

PHR: Centenarian cognitive superagers have exceptional cognitive function despite extreme exposure to the strongest risk factor for cognitive impairment and Alzheimer's disease, aging. The “Resilience/Resistance to AD in Centenarians and Offspring” (RADCO) Study gauges cognitive resilience among centenarian cognitive superagers and their offspring using cognitive testing, neuroimaging, blood biomarkers, and neuropathology and translational studies will identify protective factors and underlying mechanisms that confer resilience or in some cases, even resistance against cognitive decline and dementia.

PI_NAMEs: ANDERSEN, STACY ;BOOKHEIMER, SUSAN Y;PERLS, THOMAS T (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: 3-Dimensional;age related;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Area;arm;Astrocytes;Biological;Biological Assay;Biological Markers;Biology;Blood;Brain;Brain Pathology;Cell Line;Cellular Assay;Centenarian;circulating biomarkers;Cognitive;cognitive function;cognitive testing;Data;Dementia;Development;disability;drug candidate;Drug usage;endophenotype;exome;Exposure to;falls;Functional Magnetic Resonance Imaging;gene discovery;Genes;genetic variant;Human;Impaired cognition;in vitro Model;indexing;induced pluripotent stem cell;Life Expectancy;Measures;Microglia;microRNA biomarkers;MicroRNAs;Modeling;molecular resilience;Nerve Degeneration;neural;neuroimaging;neuroinflammation;Neurons;neuropathology;Neuropsychology;offspring;Organoids;Pathway interactions;Pharmaceutical Preparations;Phenotype;Plasma;promote resilience;Prospective Studies;protective factors;protective pathway;resilience;resilience biomarker;Resistance;Risk;Risk Factors;RNA Sequences;Sampling;Septuagenarian;Serum;sex;Spouses;super ager;Testing;Therapeutic;therapeutic target;Tissues;Translating;translational study;Translations;Work

PROJECT_TITLE: Resilience/Resistance to Alzheimer's Disease in Centenarians and Offspring (RADCO)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: PERLS, THOMAS T (contact)

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: Substance abuse disorders are a chronic human condition where initial consumption leads to long-lasting behavioral changes, driven in part by initial, and then progressive resistance to the intoxicating effects of alcohol as tolerance develops. The results of the proposed studies will provide valuable mechanistic insight into the way initial ethanol exposure causes these long-lasting behavioral changes. This will highlight novel targets for therapeutic intervention with alcohol addiction, which are largely lacking.

PI_NAMEs: ROTHENFLUH, ADRIAN  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Actins;Acute;addiction;Affect;Alcohol abuse;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;Alcohol Phenotype;alcohol response;alcohol sensitivity;alcohol use disorder;Alcoholic Intoxication;Alcohols;Anatomy;Antidotes;Area;ATAC-seq;Automobile Driving;Behavior;Behavior Control;Behavioral;Behavioral Mechanisms;behavioral response;Binding;Biological;Brain;Candidate Disease Gene;candidate identification;candidate validation;Cells;Chromatin;Chronic;Collaborations;Consumption;Cytoskeleton;Data;Dependence;Development;Disease;DNA;dopaminergic neuron;driving force;Drosophila genus;Elements;Engineering;Enhancers;epigenome;Ethanol;experimental study;Family;Feasibility Studies;fly;Funding;gamma-Aminobutyric Acid;Gene Expression Regulation;Genes;Genetic;genetic approach;Genetic Predisposition to Disease;Genetic Transcription;genome wide association study;Goals;Grant;GTPase-Activating Proteins;Guanine;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;Health;Health Hazards;Human;Human Genome;improved;in vivo;in vivo evaluation;Individual;inhibitor;innovation;insight;interest;Intervention;Intoxication;Link;Location;Measures;Mediating;member;Methods;model organism;Modeling;Molecular;Monomeric GTP-Binding Proteins;Motor;National Institute on Alcohol Abuse and Alcoholism;neural;neural circuit;Neurons;Neurotransmitters;new therapeutic target;Nucleic Acid Regulatory Sequences;Orthologous Gene;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Populations at Risk;preference;Promoter Regions;Protein Isoforms;Publications;Publishing;rational design;Regulation;Regulator Genes;Regulatory Element;Research;Research Personnel;Resistance;response;Rewards;rho;rho GTP-Binding Proteins;Risk Factors;Role;RSU1 gene;Sedation procedure;Signal Transduction;Societies;Specificity;Substance abuse problem;System;Testing;Therapeutic Intervention;Tissue-Specific Gene Expression;Tissues;transcription factor;Transcriptional Regulation;transcriptome;transcriptomics;translational approach;translational impact;Translational Research;United States

PROJECT_TITLE: Control of Alcohol Responses by Actin-Regulating Genes

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


PHR: Overall Project Narrative Post-transplant cyclophosphamide (PTCy) has lowered the non-relapse mortality after allogeneic BMT to less than 10% even in the mismatched setting. This proposal will study the period after allogeneic BMT as a unique time to study maintenance therapy to reduce relapse. In addition, the now near universal availability of the procedure, enabled by the favorable safety and cost profile associated with PTCy, opens up examining alloBMT for unique applications, such as solid tumors and HIV.

PI_NAMEs: JONES, RICHARD J (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Acute Myelocytic Leukemia;Adoptive Cell Transfers;Age;AIDS related cancer;Allogenic;Antineoplastic Agents;Autologous;Autologous Transplantation;Biology;Blood;Blood donor;Bone Marrow Transplantation;Budgets;cancer stem cell;Cell Therapy;Cells;Clinic;Complication;cost;Cyclophosphamide;Data;Development;Environment;Excision;FLT3 gene;Funding;Goals;Grant;Guidelines;HIV;human disease;Immune system;Immunologics;Immunotherapy;improved outcome;Infiltration;Infrastructure;International;Laboratories;Leadership;leukemia;Life;Lymphocyte;Lymphoma;Maintenance Therapy;Malignant Neoplasms;Marrow;Morbidity - disease rate;mortality;Multiple Myeloma;Non-Malignant;novel;novel therapeutics;Outcome;Patients;post-transplant;Procedures;programs;Registries;Relapse;Residual Neoplasm;rituximab;Safety;Science;Second Degree Relative;small molecule;Solid Neoplasm;stem cell biology;Structure;Therapeutic;Time;Translational Research;translational study;Translations;Transplantation;Transplantation and Immune System;tumor;Tumor Burden;tumor heterogeneity;Tyrosine Kinase Inhibitor;virtual;Work

PROJECT_TITLE: Bone Marrow Transplantation in Human Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: BOOKHEIMER, SUSAN Y (contact)

PROJECT_TERMS: Adult;Age;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-42;Apolipoprotein E;arterial spin labeling;Attenuated;Behavioral;Bilateral;Biological;Biological Assay;Biological Markers;Blood flow;Brain;Brain imaging;Brain region;brain tissue;Centenarian;Characteristics;Child;Clinical;Cognitive;cognitive function;cohort;cytokine;Dementia;endophenotype;Exposure to;Functional Magnetic Resonance Imaging;high risk;Hippocampus;Hour;Human Resources;Image;Imaging Techniques;Impaired cognition;indexing;Individual;Liquid substance;Longevity;Magnetic Resonance Imaging;Magnetism;Maps;Measures;Medial;mild cognitive impairment;Myelin;Nerve Degeneration;neuroimaging;neuroinflammation;neuropathology;Neuropsychology;offspring;Older Population;Outcome;Parietal Lobe;Participant;Pathologic;Phenotype;Plasma;Positron-Emission Tomography;Predisposition;preservation;protective factors;Recovery;Research Personnel;resilience;Resistance;resistance mechanism;Resolution;Resources;Rest;Risk Factors;Sampling;Spouses;super ager;tau aggregation;tau-1;Testing;therapeutic candidate;Thick;transcriptomics;white matter;White Matter Hyperintensity

PROJECT_TITLE: Resilience and Resistance Phenotypes


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: NARRATIVE Veterinarians play a central role in protecting animal and human health by preserving the efficacy of the antibiotics that their use for their patients. We have created a partnership among a public university, private veterinary hospitals, and a leading industry partner to collect information on how antibiotics are being used in cat and dog practices across the country with no disruption to the participating hospitals. The data will support FDA’s commitment to promoting antimicrobial stewardship.

PI_NAMEs: LANZAS, CRISTINA  (contact)

PROGRAM_OFFICER_NAME: HUEBNER, KATHERINE

PROJECT_TITLE: Automated Data Collection on Antimicrobial Use in Dogs and Cats in a Tertiary Hospital and Private Practices


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Cystic Fibrosis;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Pneumonia;Pneumonia and Influenza;Rare Diseases;Vaccine Related

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE. New approaches to fight Pseudomonas aeruginosa infections are desperately needed. We have already generated a monoclonal antibody to the conserved essential protein EF-Tu and shown it to be able to decrease colonization in a murine model of acute P. aeruginosa pneumonia. Here we will screen spleen cells from immunized mice and blood from humans with high titer antibodies to EF-Tu at single cell level using flow cytometry and an innovative nanoculture microfluidic array, respectively, to generate additional monoclonal antibodies to EF-Tu with even more efficacy based on in vitro binding assays, opsonophagocytic killing, and mouse challenge studies, as a first step to develop novel reagents to treat infections caused by this opportunistic pathogen.

PI_NAMEs: GOLDBERG, JOANNA B (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Active Immunization;Acute;Affinity;Antibiotic Resistance;Antibodies;Antibody Therapy;Antibody titer measurement;Antigens;antimicrobial;B-Lymphocytes;Bacteremia;Bacteria;Bacterial Antibiotic Resistance;Binding;Biological Assay;Blood;Capsicum;Cells;Cellular Structures;Chronic;Clinical Research;Cloning;combat;Communicable Diseases;COVID-19 patient;cystic fibrosis infection;cystic fibrosis patients;Development;Epitope Mapping;Epitopes;fighting;Flow Cytometry;Functional disorder;fungus;Future;Goals;Grant;hospital care;Hospitals;Human;Immune system;immune system function;Immunize;Immunocompromised Host;immunogenic;immunological status;improved;In Vitro;Individual;Industrialization;Infection;Injury;innovation;interest;Investigation;Island;Life;Lipopolysaccharides;Lung infections;Membrane Proteins;Methods;Microfluidics;Modeling;Monoclonal Antibodies;mouse model;Mus;Nature;Nosocomial Infections;Nosocomial pneumonia;novel;novel strategies;novel therapeutics;opportunistic pathogen;passive antibodies;pathogen;patient population;Patients;Peptide Elongation Factor Tu;Peripheral Blood Mononuclear Cell;Persons;Phagocytes;Pharmacologic Substance;Physiological;Pneumonia;pneumonia model;Polysaccharides;post SARS-CoV-2 infection;Process;Protein Biosynthesis;Proteins;Protocols documentation;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pseudomonas aeruginosa pneumonia;Reagent;Resistance profile;response;Role;Serotyping;Sorting;Spain;Spleen;superinfection;Surface;Testing;Time;Universities;vaccine access;vaccine immunogenicity;Vaccines;Washington;Work

PROJECT_TITLE: Monoclonal Antibody to Combat Pseudomonas Aeruginosa


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

PI_NAMEs: KIM, DOO YEON  (contact)

PROJECT_TERMS: 3-Dimensional;abeta accumulation;age related;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Area;Astrocytes;Autopsy;Biological;Blood;Brain;brain cell;Brain Pathology;Brain region;candidate validation;Cell Line;Cell model;Cellular Assay;Centenarian;circulating biomarkers;Code;Cognitive;Data;Dementia;Disease;drug candidate;Drug usage;endophenotype;exome;Exposure to;Gene Frequency;Genes;Genetic;genetic variant;Goals;Human;Impaired cognition;Impairment;induced pluripotent stem cell;Life Expectancy;Measures;Microglia;microRNA biomarkers;MicroRNAs;Modeling;Molecular;molecular resilience;neural;Neuroglia;neuroimaging;Neurons;offspring;Organoids;Pathway interactions;Pharmaceutical Preparations;Phenotype;Privatization;Process;promote resilience;Prosencephalon;protective allele;protective factors;Research;resilience;resilience biomarker;Resistance;Risk Factors;RNA Sequences;Serum;sex;Spouses;super ager;Testing;Therapeutic;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Protective factors and mechanisms


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because visual object recognition and learning is implicated in broad array of cognitive tasks in early the learning of first words, reading and learning the symbol systems of mathematic; the continued risks of children treated for amblyopia and strabismus in perceptual, cognitive and school achievements and the nexus of disrupted visual learning and lexical development in children with Developmental Language Delay and Autism. Understanding infants self-generated active visual experiences is expected to give rise to new diagnostics and behavioral interventions for at-risk infants. Thus, this proposal is relevant to NIH’s mission that pertains to fostering fundamental discoveries and innovative research strategies as a basis for ultimately protecting child health.

PI_NAMEs: SMITH, LINDA B. (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 1 year old;Achievement;Age Months;aged;Algorithms;Amblyopia;autism spectrum disorder;Behavior;Behavior Therapy;Benchmarking;Canis familiaris;Categories;Child;Child Health;Clutterings;Cognitive;cognitive task;Data;Development;Educational process of instructing;experience;Eye;Flowers;Fostering;Foundations;Free Will;Geometry;Goals;Head;Health;Human;Image;Individual;infancy;Infant;innovation;interest;Language Delays;Learning;lexical;Link;Literature;Machine Learning;Mathematics;Measures;member;Methods;Mission;Motor;Movement;Names;Nature;novel;novel diagnostics;object perception;object recognition;Orthography;Pathway interactions;Perception;Play;Preparation;Problem Solving;Process;programs;Property;Public Health;Reading;Reporting;Research;Research Project Grants;Risk;Risk Factors;Role;Schools;Sensory;sensory input;Shapes;skills;Specific qualifier value;statistics;Strabismus;success;System;Testing;Time;Toddler;United States National Institutes of Health;Variant;Vision;Visual;visual cognition;visual information;visual learning;visual object processing;Visual System;word learning;Work

PROJECT_TITLE: Infants' self-generated visual statistics support object and category learning


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: ANDERSEN, STACY  (contact)

PROJECT_TERMS: Affect;Age;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid beta-42;Anatomy;Area;Autopsy;biobank;Biological;Biological Assay;Biological Markers;Blood specimen;Boston;Brain;Centenarian;Clinical Data;Cognitive;cognitive function;Consensus;COVID-19;cytokine;Data;Data Collection;data de-identification;data management;data sharing;Dedications;Dementia;Diagnosis;Disease Marker;Eligibility Determination;Enrollment;Ensure;exome;experience;Familiarity;Fasting;Funding;Future;Gene Expression;Genetic;Genetic Transcription;Impaired cognition;Impairment;innovation;Investigation;Knowledge Portal;Lead;Link;Longevity;Los Angeles;Measures;Mission;Modeling;Molecular;Neurocognitive;neuroimaging;neuropathology;Neuropsychological Tests;Neuropsychology;New York City;offspring;Older Population;Outcome;Participant;participant enrollment;Pathologic;Patient Recruitments;Phenotype;phenotypic data;Plasma;protective factors;recruit;Research Personnel;resilience;Resistance;Resources;RNA;Sampling;Scanning;Secure;Spouses;Statistical Data Interpretation;success;super ager;symposium;System;Tissues;tool;transcriptomics;translational potential;virtual;Work

PROJECT_TITLE: Phenotyping and Biospecimen Core


NIH_SPENDING_CATS: Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative:  The lung alveolar epithelium is exposed to the environment and pathogens and is thus highly susceptible to injury. Repair of the alveolar epithelium requires the activation of alveolar epithelial stem cells by signals from their surrounding niche. In this proposal we address a novel mechanism of bioactive lipid mediated interaction between lung microvascular endothelial cells and alveoli epithelial cells in the reparative niche, and hope to throw new light on the fundamental mechanisms driving lung repair after injury.

PI_NAMEs: LIU, YURU  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: 3-Dimensional;Address;Adhesives;Adult;Agonist;AGTR2 gene;Alveolar;Alveolar Cell Type I;alveolar epithelium;Alveolus;analog;Area;Automobile Driving;Carbon Dioxide;Cell Adhesion;Cell Culture Techniques;Cell Lineage;Cell Shape;Cell surface;Cells;Coculture Techniques;Cytoskeleton;Endothelial Cells;Endothelium;Environment;Enzymes;Epithelial Cells;epithelial repair;epithelial stem cell;Exhibits;Exposure to;genetic approach;Genetic Transcription;Injury;injury and repair;innovation;inorganic phosphate;Knockout Mice;Knowledge;Label;Light;Lipids;Lung;lung injury;lung microvascular endothelial cells;lung repair;Mediating;Modeling;mouse model;Mus;Mutant Strains Mice;novel;Nuclear Translocation;pathogen;Pathway interactions;pharmacologic;Play;Predisposition;Process;Production;programs;Proteins;Pseudomonas aeruginosa;receptor;Regulation;repaired;reparative capacity;Research;response;restoration;Role;Shapes;Signal Transduction;Signaling Protein;SPHK1 enzyme;Standardization;stem cell function;Surface;surfactant;Testing;Therapeutic;Thinness;tissue stem cells;Type II Epithelial Receptor Cell

PROJECT_TITLE: Bioactive lipid mediated Endothelial niche regulation of alveolar epithelial repair

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: NARRATIVE Patients have cardiac outflow tract defects frequently requiring medical intervention. The affected cardiac outflow tract structures include cardiac septum and semilunar valves derive from embryonic progenitor cells in neural crest tissue and endocardium. This research project will determine the molecular and cellular mechanisms downstream of the 22q11.2 deleted region that regulate the functions of these progenitor cells to form the cardiac outflow tract.

PI_NAMEs: MORROW, BERNICE E;ZHOU, BIN  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: 22q11;22q11.2;3-Dimensional;Affect;bicuspid aortic valve;Biological Assay;Cardiac;cardiogenesis;Cell Communication;Cell Lineage;cell motility;Cells;Clinical;Code;congenital heart abnormality;connective tissue growth factor;Defect;Development;Developmental Biology;DiGeorge Syndrome;Disease;Distal;Early identification;Embryo;embryonic stem cell;Endocardium;Endothelin-1;Ensure;experimental study;gene interaction;Genes;Genetic;genetic signature;genetic variant;Heart;Heart Septum;Histology;Human;Immunofluorescence Immunologic;In Situ Hybridization;in vivo;Intervention;Knowledge;Live Birth;malformation;Medical;Mesenchymal;Modeling;Molecular;Morphogenesis;mouse model;Mus;mutant;Mutation;Neural Crest;Neural Crest Cell;Neural tube;Neurophysiology - biologic function;Newborn Infant;NOTCH1 gene;Outcome;Patients;Pattern;Persistent Truncus Arteriosus;Phenotype;Population;Positioning Attribute;Prevalence;Process;programs;Proteins;Pulmonary Circulation;reconstruction;Research Project Grants;restoration;Role;semilunar valve;Signal Transduction;single-cell RNA sequencing;stem cell function;stem cells;Structural defect;Structure;Testing;Tetralogy of Fallot;Tissues;Validation;Ventricular Septal Defects;Ventricular septum

PROJECT_TITLE: Molecular and cellular mechanisms in cardiac outflow tract formation and defects

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative As acquisitions of primary care practices by private equity (PE) firms accelerate nationwide, this proposal focuses on the specific mechanisms by which PE firms may alter provider behavior under different financial incentives in Traditional Medicare and Medicare Advantage, which together cover primary care services for nearly 60 million Americans. We apply newer statistical methods to estimate PE's effects on quality of care and patient outcomes, as well as to assess heterogeneous treatment effects across different patient populations and impacts on health care equity. Findings will provide novel, timely, and comprehensive quantitative assessments of this growing trend of PE practice ownership, helping to inform ongoing state and federal policy efforts to support access to high-value primary care.

PI_NAMEs: SONG, ZIRUI ;ZHU, JANE MINGJIA (contact)

PROGRAM_OFFICER_NAME: EDEN, AIMEE

PROJECT_TITLE: Private Equity Acquisitions in Primary Care: Effects on the Medicare Program

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PROJECT_TERMS: aged;Aging;Alzheimer's Disease;Area;arterial spin labeling;Attenuated;Boston;Brain;Centenarian;Characteristics;Cognition;Cognitive;cognitive ability;cognitive function;Data;data acquisition;Data Analyses;data integration;data repository;Dementia;design;ethnic diversity;experience;Functional Magnetic Resonance Imaging;Goals;Image;Image Analysis;image processing;imaging facilities;Liquid substance;Los Angeles;Magnetic Resonance Imaging;Magnetism;Maps;Measures;Memory;Methods;metropolitan;Modality;neuroimaging;Noise;normal aging;offspring;Output;Parents;Persons;Phenotype;Physiologic pulse;Population;Predisposition;preservation;prisma;quality assurance;racial diversity;Records;Recovery;Research Personnel;resilience;resilience factor;Resistance;Resolution;Rest;Sampling;Site;Spouses;Standardization;statistics;Structure;super ager;Techniques;Testing;time interval;tool;Travel;Universities;Utah

PROJECT_TITLE: Neuroimaging Core


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Understanding the genomic basis of human milk composition is key to developing precision nutrition for preterm infants and other clinical populations of interest. We will take a multi-omic, systems-level view of the mother-milk-infant triad, identifying novel relationships linking maternal and infant health to milk composition. To accelerate milk biosystems discovery, our findings will be shared with the research community through creation of a web-based portal and corresponding data visualization tools.

PI_NAMEs: BLEKHMAN, RAN ;DEMERATH, ELLEN W. (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Acceleration;Behavioral;Biological;biological systems;Birth;Body Composition;cell type;Cells;Cellular biology;Clinical;clinically significant;Cognition;cognitive testing;cohort;Cohort Studies;Communities;Complex;cytokine;Data;data quality;Data Set;data visualization;Development;Diet;donor milk;Educational workshop;Elements;Exclusive Breastfeeding;fecal microbiome;Fortification;Gene Expression;Genetic;genetic association;Genetic Determinism;genomic data;Genomics;gestational weight gain;Goals;Growth;gut health;gut microbiome;Health Benefit;Human;Human Milk;human milk oligosaccharides;human tissue;Individual;Infant;Infant Development;infant gut microbiome;Infant Health;innovation;interest;Life;Link;lipidomics;Lipids;Machine Learning;mammary;Maternal Health;Maternal Physiology;Metabolic dysfunction;metabolomics;microbiome research;Milk;milk microbiome;Milk Substitutes;Modification;Molecular;Molecular Biology;Mothers;Multiomic Data;multiple omics;National Institute of Child Health and Human Development;next generation;novel;Nutritional Support;offspring;Oligosaccharides;Participant;Phenotype;Physical activity;Population;precision nutrition;Premature Infant;Recipe;Research;Research Personnel;Sampling;Shapes;single-cell RNA sequencing;Source;Specimen;statistical and machine learning;Structure;System;Systems Biology;Techniques;Time;transcriptome;United States National Institutes of Health;Variant;Visualization;Visualization software;web portal;Woman;Work

PROJECT_TITLE: Milk-Omics: Systems Biology of Human Milk and Its Links to Maternal and Infant Health


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Emerging HIV treatment and prevention formulations have the potential to expand choices for young people, who face unique challenges to access and use of existing options. Concerns about cost may limit both offering and uptake of new treatments in many settings with severely constrained budgets. We propose to adapt and expand the structure of an adolescent-focused HIV simulation model and to assemble the necessary data to identify the most effective and cost-effective medications and monitoring strategies for the treatment and prevention of HIV among adolescents and young adults in South Africa.

PI_NAMEs: NEILAN, ANNE  (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Address;Adherence;Adolescence;Adolescent;Adolescent and Young Adult;adolescent health outcomes;Adolescent Medicine;Affect;Age;Age Factors;age group;AIDS prevention;Antibodies;Antigens;antiretroviral therapy;Behavior;Budgets;Caring;Cessation of life;Chronic Disease;Clinical;Clinical effectiveness;Clinical Research;Clinical Trials;cohort;Collaborations;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;Data;Death Rate;Decision Making;Development;Diagnosis;Disclosure;Economic Models;Enrollment;Epidemic;Epidemiology;Event;experience;Female;flexibility;Formulation;Foundations;Future;Genotype;Goals;Health;Health behavior;health economics;Health Services Accessibility;HIV;HIV Infections;HIV/AIDS;improved;improved outcome;Impulsivity;Incidence;Infection;Injectable;innovation;Intervention;Intervention Trial;Life Expectancy;low and middle-income countries;male;Methods;Modality;Modeling;models and simulation;Monitor;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;novel;Opportunistic Infections;Oral;Outcome;Outcome Assessment;Persons;Pharmaceutical Preparations;pill;Policies;pre-exposure prophylaxis;prevent;Prevention;Prevention strategy;preventive intervention;Public Health;Regimen;Resources;Risk Factors;Risk Taking;Science;sex;Sex Factors;sexual relationship;social stigma;South Africa;South African;Structure;Study models;Subgroup;System;Time;Toxic effect;treatment strategy;United States;United States National Institutes of Health;uptake;Vaginal Ring;Viral Load result;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Adolescent-tailored HIV treatment and prevention strategies in South Africa: projecting clinical benefits and value

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE This project will determine whether mast cell mediated histamine release triggered by focal neurogenic inflammation is a fundamental mediator of the acute bone resorption precipitated by muscle paralysis. While this intercellular signaling cascade has not previously been implicated in bone, its individual components are well explored in other contexts. Critically, this pathway holds substantial potential to be targeted by antihistamine therapy as a novel strategy to prevent bone loss induced by paralysis or direct neuromuscular dysfunction.

PI_NAMEs: GROSS, TED S. (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Acute;afferent nerve;antagonist;Antihistamines;Attenuated;bone;bone loss;Bone Marrow;Bone Resorption;Bone Resorption Inhibition;Botulinum Toxin Type A;Calcitonin Gene-Related Peptide;Clinical;Connective Tissue;cortical bone;Data;experience;Functional disorder;Gene Expression;Genes;Goals;H2 gene;Histamine;Histamine Antagonists;Histamine Receptor;Histamine Release;Homeostasis;Impairment;Individual;Inflammation;Inflammatory;Injury;Link;mast cell;mechanical load;Mediating;Mediator;Modeling;mouse model;Mus;Muscle;Muscle Contraction;Muscle function;Nerve;Neurogenic Inflammation;neuromuscular;neuromuscular function;Neuropeptides;novel strategies;osteoclastogenesis;Outcome;Paralysed;Pathway interactions;Pharmaceutical Preparations;Physiology;prevent;Proto-Oncogene Protein c-kit;response;Series;Signal Pathway;Signal Transduction;skeletal;Skeleton;Substance P;substantia spongiosa;theories;Therapeutic;tibia;TNFSF11 gene;translational approach

PROJECT_TITLE: Bone Marrow Inflammation and Bone Resorption

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


FUNDING_MECHANISM: RESEARCH CENTERS

PHR: PROJECT NARRATIVE Fragile X syndrome (FXS), the most common inherited form of intellectual disability and a leading genetic cause of autism spectrum disorders (ASD), is caused by the loss of functional fragile X mental retardation protein (FMRP). Recent technological development of 2D and 3D culture derived from human iPSCs provides a new platform to investigate human brain development in a dish, otherwise inaccessible to experimentation. This multi-project Center aims to establish a framework to understand the FMRP-mediated regulation of human brain development at molecular, cellular and system circuitry levels that will enable the development of therapeutic approaches to treat FXS.

PI_NAMEs: JIN, PENG  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 3-Dimensional;5' Untranslated Regions;Adherent Culture;Animal Model;Area;autism spectrum disorder;Behavioral;Binding;Biological Models;Brain;cell type;Cells;CGG repeat;Clinical Trials;crosslinking and immunoprecipitation sequencing;Data;Development;Disease;Dissection;Drosophila genus;drug discovery;Drug Modulation;Electrophysiology (science);FMR1 gene;follow-up;Fragile X Syndrome;Functional disorder;functional loss;GABA Receptor;Gene Expression Regulation;Genetic;genome editing;genome-wide;Goals;Human;Human Development;human disease;human induced pluripotent stem cells;human model;Hypermethylation;In Vitro;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inherited;Intellectual functioning disability;Knowledge;Learning;Link;Mediating;messenger ribonucleoprotein;Messenger RNA;Metabotropic Glutamate Receptors;Modeling;Molecular;mouse model;Mus;neural;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Organoids;Pharmaceutical Preparations;Polyribosomes;preclinical study;promoter;Protein Biosynthesis;Regulation;Research;Research Personnel;RNA;RNA-Binding Proteins;Rodent;Role;screening;Signal Transduction;single cell genomics;single-cell RNA sequencing;small molecule;stem cell model;stem cells;Synapses;synaptogenesis;synergism;System;Technical Expertise;Technology;technology development;Testing;Therapeutic;therapeutic development;three-dimensional modeling;tool;transcriptome;transcriptomics;Translational Regulation;Translations;translatome;Validation

PROJECT_TITLE: FMRP-mediated Regulation in Human Brain Development and Therapeutic Advancement


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PROJECT_TERMS: Accountability;Adherence;Biological Models;Biomedical Engineering;Brain;California;cloud based;Collaborations;Communication;Communities;community engagement;Data;data access;Data Collection;data repository;data sharing;data submission;Dedications;Deposition;design;Development;Disclosure;Disputes;Ensure;FMR1 gene;Foundations;Fragile X Syndrome;Funding;Gene Expression Regulation;General Population;Goals;Human;Human Resources;Individual;Information Dissemination;Information Technology;Infrastructure;innovation;Institution;large datasets;Logistics;Measurable;Mediating;medical schools;meetings;member;Messenger RNA;Molecular;Monitor;mouse model;neural;new therapeutic target;New York;novel;novel therapeutics;operation;Pennsylvania;Peripheral;Persons;Preparation;Productivity;programs;Progress Reports;Protocols documentation;public repository;Regulation;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Science;Secure;Site;success;synergism;System;Technology;Testing;Therapeutic;therapeutic development;three-dimensional modeling;tool;Training;Translational Regulation;United States National Institutes of Health;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bipolar Disorder;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Serious Mental Illness

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This proposal will leverage the Asian Bipolar Genetics Network (A-BIG-NET), an international collaboration of investigators from the U.S., Taiwan, South Korea, Singapore, India and Pakistan, to carry out a molecular genetics study of bipolar disorder in East and South Asia. It will establish a valuable genetics resource with 4x low-pass whole genome sequence and rich phenotype data that will dramatically increase the worldwide diversity of genetics data on bipolar disorder, an important step to accelerate gene discovery in this disorder and advance global mental health equity.

PI_NAMEs: ZANDI, PETER P. (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;Adopted;Adult;Alleles;Asia;Asian;Asian Americans;Asian ancestry;Asian population;Bipolar Disorder;causal variant;Clinical;cohort;Collaborations;comparative;Complement;Consensus;Country;Data;data archive;data collection site;Disease;disorder subtype;DNA;East Asian;Environmental Risk Factor;environmental stressor;Equity;European;European ancestry;experience;field study;Funding;gene discovery;Gene Frequency;Genetic;genetic architecture;genetic association;Genetic Diseases;Genetic Research;genetic resource;genetic risk factor;genetic signature;Genetic study;genetic variant;Genetic Variation;genome sequencing;genomic data;genomic locus;Genomics;Genotype;health care disparity;health disparity;health equity;India;insight;International;Joints;Maps;Measures;Mental disorders;Mental Health;Modeling;Molecular;Molecular Genetics;National Institute of Mental Health;Nature;neuropsychiatric disorder;novel;Outcome;Pakistan;Pathogenesis;Phenotype;phenotypic data;Play;pleiotropism;polygenic risk score;Population;Prevalence;Procedures;Process;Production;Protocols documentation;psychiatric genomics;psychogenetics;Public Health;Publications;Quality Control;rare variant;Records;recruit;Reduce health disparities;Reporting;Research;Research Personnel;Research Project Grants;Resources;Role;Sampling;Sampling Studies;Schizophrenia;severe psychiatric disorder;Singapore;Site;South Asian;South Korea;Taiwan;Time;Uncertainty;Variant;web portal;whole genome;Work

PROJECT_TITLE: 3/4 Asian Bipolar Genetics Network (A-BIG-NET)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-B(60)C]


NIH_SPENDING_CATS: Brain Disorders;Fragile X Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: BASSELL, GARY J (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adult;Animal Model;Automobile Driving;Behavior;Binding;Brain;Cell Proliferation;cell type;Cells;Clinical Trials;Collaborations;comparative;Coupled;crosslinking and immunoprecipitation sequencing;Data;Defect;Development;Disease;Down-Regulation;drug efficacy;effective therapy;Embryo;experimental study;Failure;fetal;FMR1 gene;Fragile X Syndrome;Hippocampus;Human;human induced pluripotent stem cells;Impairment;induced pluripotent stem cell;insight;Joints;Lentivirus;Mediating;Messenger RNA;migration;Modeling;Molecular;Molecular Target;monolayer;Morphology;mouse model;mRNA Translation;Mus;neural;neural model;neurodevelopment;neurogenesis;neuron development;Neuronal Differentiation;neuronal excitability;Neurons;neurophysiology;neurotransmission;novel;Nuclear Pore Complex;Organoids;Outcome;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phenotype;Physiological;preclinical study;primary endpoint;Proliferating;Protein Biosynthesis;Proteins;Regulation;Reporting;Retinoic Acid-Binding Proteins;ribosome profiling;RNA;Role;Signal Transduction;single-cell RNA sequencing;small molecule;Synapses;Synaptic plasticity;synergism;System;Testing;Therapeutic;Therapeutic Intervention;three-dimensional modeling;Tissues;tool development;transcriptome sequencing;translating ribosome affinity purification and RNA-sequencing;Translations;translatome;Work

PROJECT_TITLE: Project 1


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: CHEN, LU  (contact)

PROJECT_TERMS: Acute;Adult;Animal Model;Animals;Autopsy;Behavior;Behavioral;behavioral phenotyping;Biological Models;Brain;cell type;Cells;Cerebrum;Clinical Trials;Cognitive;Cognitive deficits;cognitive function;cognitive testing;Collaborations;Computer Models;Cre driver;Development;Disease;drug discovery;Electrodes;Electrophysiology (science);embryonic stem cell;Enterobacteria phage P1 Cre recombinase;environmental enrichment for laboratory animals;Exhibits;experience;experimental study;fear memory;flexibility;FMR1 gene;Fragile X Syndrome;Functional disorder;Functional impairment;Gene Expression Profiling;Genetic;Goals;Hippocampus;Human;human model;immunocytochemistry;Impairment;in vivo;induced pluripotent stem cell;insight;Investigation;Joints;knowledge base;Learning;Lentivirus Vector;Link;Long-Term Depression;Long-Term Potentiation;Mediating;Memory;memory recall;model organism;Modeling;Molecular;mouse model;Mus;Mutation;Nature;neural circuit;Neurodevelopmental Disorder;Neurologic;Neurologic Dysfunctions;neuromechanism;neuron development;Neurons;novel;Organoids;Outcome;patient derived induced pluripotent stem cells;Patients;Phenotype;prevent;Process;Regulation;Research;Research Project Grants;Runaway;Running;Signal Pathway;Signal Transduction;Slice;small molecule;Synapses;synaptic function;Synaptic plasticity;synergism;System;Testing;Therapeutic;Therapeutic Intervention;Tissues;tool development;Tretinoin;virtual;Work

PROJECT_TITLE: Project 2