ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: NARRATIVE Loss of the Y chromosome in the blood of males increases with age, and it is associated with diminished survival and an increase risk of various diseases. However, it is not known if the loss of the Y chromosome has a causal role in age-associated diseases or whether it is an epiphenomenon of biological aging processes. We will employ novel mouse models to test whether the loss of the Y chromosome in blood cells impacts pathological cardiac remodeling.

PI_NAMEs: WALSH, KENNETH  (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Ablation;Address;Age;age related;Age related pathologies;age-related disease;aging biomarker;aging process;aorta constriction;ATAC-seq;Biological Aging;Blood;Blood Cells;Cardiac;Cardiometabolic Disease;cardioprotection;Cardiovascular Diseases;cardiovascular risk factor;chromosome Y loss;Coculture Techniques;Code;coronary fibrosis;CRISPR/Cas technology;Data;Disease;DNA Sequence Alteration;Elderly;epidemiology study;Exhibits;Fibroblasts;Frequencies;gene-editing approach;Genes;Genomic Instability;Heart;Heart failure;Hematologic Neoplasms;Hematopoiesis;Hematopoietic Neoplasms;Histologic;Human;Hypertrophy;Infiltration;Inflammation;interest;Knockout Mice;Knowledge;life span;Light;Link;Macrophage;male;men;Modeling;mortality;mosaic loss;Mosaicism;mouse model;Mus;Mutate;Mutation;Myocardial;Myocardium;novel;Pathologic;Phenotype;Precancerous Conditions;premalignant;pressure;Procedures;Process;Proteins;Recurrence;Research;Risk;Role;Sex Differences;Signal Transduction;targeted treatment;Technology;Testing;Therapeutic;Transforming Growth Factor beta;Woman;Work;Y Chromosome

PROJECT_TITLE: Mosaic loss of Y chromosome in blood and heart failure

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Asthma;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_CITY: TUCSON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PI_NAMEs: CHU, HONG W (contact)

PROJECT_TERMS: airway epithelium;airway inflammation;airway obstruction;Alleles;Allergens;Anti-viral Therapy;Asthma;asthma exacerbation;asthmatic;asthmatic airway;Binding;Biological Response Modifiers;Body Weight decreased;Cell model;Cells;Confocal Microscopy;CRISPR/Cas technology;cytokine;Distal;Dot Immunoblotting;Environmental Risk Factor;eosinophil;Epithelial Cells;epithelial injury;epithelial wound;Exposure to;Genetic;Genetic Transcription;Goals;Goblet Cells;Human;Hyperplasia;Inflammation;Inflammatory;Influenza A virus;influenza infection;influenzavirus;injured airway;innovation;Interleukin-13;Knockout Mice;Lung;Mediating;Membrane;mouse model;mRNA Expression;MUC5AC gene;Mucins;Mucous body substance;Mus;Natural Immunity;neutrophil;Neutrophil Infiltration;novel;Pathogenesis;Production;promoter;protein expression;Pyroglyphidae;receptor;receptor binding;Regulation;respiratory infection virus;Respiratory syncytial virus;respiratory virus;Rhinovirus;Role;Signal Transduction;single-cell RNA sequencing;STAT3 gene;Testing;TGF-beta type I receptor;tissue injury;Tissues;TOLLIP gene;transcription factor;Transcriptional Regulation;Transforming Growth Factor Beta 2;Viral;Viral Load result;Viral Respiratory Tract Infection;Virus;Virus Diseases;Western Blotting;Work;wound healing

PROJECT_TITLE: Tollip inhibits IL-33 signaling during airway influenza virus infection


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision

ORG_CITY: COLUMBIA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project narrative Understanding how eye lens crystallins can be activated and whether the activated crystallins have better cellular protection capacity will help future studies of identifying most active form of crystallins to treat disease conditions. The proposed study will include studies on the changes occurring in crystallin protein molecule during activation and testing the active preparations in cell culture models replicating stress conditions.

PI_NAMEs: SHARMA, KRISHNA K (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: 3-Dimensional;Adult;Affect;age related;Amyloid beta-Protein;Apoptosis;Apoptotic;Arginine;Biological;Biological Response Modifier Therapy;Cataract;Cell Culture Techniques;Cells;Chemicals;Complex;Crosslinker;Cryoelectron Microscopy;Crystalline Lens;Crystallins;Cytoprotection;Development;Disease;Engineering;experimental study;Exposure to;Family suidae;fascinate;Fluorescence Resonance Energy Transfer;Future;gain of function;Goals;Grant;Hydrogen Peroxide;image processing;In Vitro;in vivo;insight;Investigation;Knowledge;Lead;lens;lens transparency;macromolecule;Maintenance;Measures;Methods;Mitochondria;Modality;Modeling;Modification;Molecular;Molecular Chaperones;mutant;Mutation;novel;oxidative damage;Oxidative Stress;particle;Pathway interactions;Phosphorylation;Phosphorylation Site;Preparation;preservation;prevent;Prevention;Property;Protein Conformation;Protein Engineering;Proteins;Recombinants;reconstruction;replication stress;Reporting;Research Personnel;Resistance;Role;Site;Site-Directed Mutagenesis;small molecule;sodium iodate;Sodium Selenite;stem;Stress;Structure;Structure-Activity Relationship;System;Techniques;Testing;Therapeutic;three dimensional structure;tool;Toxic effect;α-Crystallins

PROJECT_TITLE: Metastable Crystallins: Structure and Stabilization

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: The overall goal of this proposal is to develop a targeted delivery system for immunoregulatory molecules in transplantation that increases their efficacy and diminishes their toxicity, thereby improving transplantation outcomes.

PI_NAMEs: ABDI, REZA  (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: absorption;Acceleration;Achievement;Address;Affinity;Alloantigen;allograft rejection;Allograft Tolerance;Allografting;Antibody-drug conjugates;Antigens;Biodistribution;Biological Assay;Cardiovascular Diseases;Cardiovascular system;Cause of Death;CD3 Antigens;Cells;clinical application;collaborative approach;combinatorial;Consumption;Data;design;Development;dosage;Dose;draining lymph node;Drug Delivery Systems;Drug Kinetics;Drug Targeting;effector T cell;efficacious treatment;Encapsulated;Engineering;Equilibrium;experimental study;Failure;Family;Formulation;Future;Generations;Goals;Graft Rejection;heart allograft;Heart Transplantation;High Endothelial Venule;imaging study;Immune;Immunobiology;immunoregulation;improved;in vivo;innovation;intradermal injection;lymph nodes;Lymphatic;Malignant Neoplasms;Mammals;Medical;Membrane Proteins;Metabolic syndrome;Methods;Molecular;Monoclonal Antibodies;Morbidity - disease rate;multidisciplinary;Mus;nanocarrier;Nanodelivery;nanoparticle;Nanotechnology;nonhuman primate;novel;novel strategies;novel therapeutics;Organ;Organ failure;Organ Transplantation;Outcome;Pathogenesis;Patients;Peripheral;Pharmaceutical Preparations;Process;Regulatory T-Lymphocyte;Research;Safety;Shapes;Sirolimus;Site;Skin Transplantation;success;sugar;Surface;surface coating;System;T-Lymphocyte;targeted delivery;Techniques;Testing;Therapeutic;Therapeutic immunosuppression;Time;Toxic effect;transplant model;Transplant Recipients;Transplantation;virtual

PROJECT_TITLE: Lymph Node Delivery in Transplantation


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: EL PASO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO

ORG_STATE: TX

PHR: Project narrative  MicroRNAs (miRNAs) enrichment was detected at synapse and synaptosomal components; however, the status of synaptosomal miRNAs and their precise roles in Alzheimer's disease progression are completely unexplored. Present study is designed to determine the status of synaptosomal and cytosolic miRNAs in Alzheimer's disease and to unveil their possible roles in amyloid-β and p-tau induced synaptic damage and cognitive dysfunction. The outcome of our study is expected to provide new insights about synaptosome- specific miRNAs and their therapeutic relevance in synaptic dysfunction in Alzheimer's disease.

PI_NAMEs: KUMAR, SUBODH  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Age;Alzheimer's Disease;Alzheimer's disease brain;Amyloid beta-Protein;Autopsy;base;Behavior;Behavioral;Biochemical;Brain;brain control;Cognitive;cognitive function;Complementary DNA;Complex;Data Analyses;Dendritic Spines;design;Development;differential expression;Disease Progression;frontal lobe;Functional disorder;Genes;Genomics;Goals;Hippocampus;Impaired cognition;improved;In Vitro;inhibitor;insight;Knockout Mice;Lead;Link;Mediating;Messenger RNA;Microarray Analysis;MicroRNAs;miRNA expression profiling;Mitochondria;Molecular;Mus;mutant;Neurodegenerative Disorders;neuronal growth;Neurons;neurotransmission;Neurotransmitter Receptor;Neurotransmitters;Outcome;Outcome Study;Pathogenesis;Pathology;Physiological;postsynaptic;postsynaptic density protein;presynaptic;Process;Property;Protein Biosynthesis;Proteins;Proteomics;Publishing;Quantitative Reverse Transcriptase PCR;Regulation;Reporting;Research;RNA;Role;Signal Transduction;Small RNA;Synapses;synaptic function;Synaptic plasticity;Synaptic Vesicles;Synaptosomes;tau mutation;tau Proteins;tau-1;Testing;Therapeutic;therapeutic miRNA;Toxic effect;Transcript;transcriptome sequencing;Transfection;Transgenic Organisms;United States National Institutes of Health;Wild Type Mouse

PROJECT_TITLE: Synaptosomal MicroRNAs, Synaptic Damage and Cognitive Decline in Alzheimer's Disease


NIH_SPENDING_CATS: Asthma;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Lung

PI_NAMEs: KRAFT, MONICA  (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;Acute Respiratory Distress Syndrome;airway epithelium;airway immune response;alveolar type II cell;Antiinflammatory Effect;Asthma;asthmatic;Attenuated;Binding;Biology;cell type;Cells;chemokine;Chronic;Chronic Obstructive Pulmonary Disease;Collectins;Communities;comorbidity;Country;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 severity;COVID-19 susceptibility;COVID-19 treatment;cytokine;cytokine release syndrome;Data;Distal;epidemiology study;Epithelial Cells;Epithelium;Event;Exhibits;Extrinsic asthma;Family;Genetic Transcription;Human;IL-6 inhibitor;Immune response;Immunomodulators;Infection;Inflammation Mediators;Inflammatory Response;Influenza;inhibitor;Innate Immune Response;Interferons;Interleukin 6 Receptor;Interleukin-13;Interleukin-4;Interleukin-6;Investigation;kidney epithelial cell;lung basal segment;Mediating;member;Modeling;Molecular;mortality;mouse model;Natural Immunity;new pandemic;Nose;novel;Participant;Pathogenesis;Phase;Phenotype;Preparation;programs;protective effect;Pulmonary Surfactant-Associated Protein A;receptor;receptor binding;Receptor Inhibition;Research;Respiratory Tract Infections;respiratory virus;response;Role;SARS-CoV-2 infection;Serum;severe COVID-19;Severities;Signal Pathway;Signal Transduction;synergism;Testing;tocilizumab;Viral;virology;Virus;Virus Diseases;Vision;Work

PROJECT_TITLE: Surfactant Protein-A and Type 2 Asthma in SARS-CoV-2 Infection


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Arthritis;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE The active role of osteocytes, cells embedded within bone, in maintaining skeletal health is disrupted with aging. Here we test the possibility that the disruption of osteocyte function with age contributes to age-related bone fragility and joint degeneration. Testing this hypothesis will advance our understanding of the cellular and molecular mechanisms controlling bone quality and joint disease, which will improve the success of clinical efforts to protect musculoskeletal health throughout the lifespan.

PI_NAMEs: HERNANDEZ, CHRISTOPHER JOHN (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Ablation;Acids;Address;Age;age related;age related decline;aged;Aging;aging population;Agonist;arthropathies;biobank;bone;Bone Density;bone fragility;bone loss;bone mass;Bone Matrix;Bone necrosis;bone quality;Cells;cellular targeting;Clinical;clinical development;clinically relevant;cohort;collagenase 3;Communication;cortical bone;Coupled;Data;Defect;Degenerative polyarthritis;Development;differential expression;Disease;Enzymes;Face;Femur;Fracture;gain of function;Genes;Genetic Epistasis;genome wide association study;genome-wide;Goals;Health;Histologic;Homeostasis;Human;human data;Human Genome;Impairment;improved;In Vitro;in vivo;joint destruction;Joints;Knee joint;life span;Link;loss of function;Metabolic Control;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;mouse model;Mus;Musculoskeletal;novel;Oral health;Orthologous Gene;Osteocytes;Outcome;Pathway Analysis;Pattern;Peptide Hydrolases;Phenotype;Pilot Projects;Play;Population;prevent;Process;Property;Publishing;radiological imaging;Regulation;Research;response;Role;Signal Transduction;skeletal;skeletal disorder;Specimen;success;Temporomandibular Joint;Testing;transcriptome sequencing;Transforming Growth Factor beta;Work

PROJECT_TITLE: The mechanistic control of bone quality and joint crosstalk by osteocytes

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: MILWAUKEE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: The Medical Student Summer Research Program (MSSRP) aims to foster the development of biomedical, behavioral and clinical researchers among medical students who are in the early stages of their career decision-making. The MSSRP’s immersive approach exposes students to both the scientific principles underlying cardiovascular, pulmonary and hematological diseases and their translation to new clinical paradigms during intense, summer experiences encompassing laboratory and didactic training within an integrated and collaborative scientific environment. The overall goal is to help ensure that an adequate supply of diverse, well-trained physician scientists is available to address the needs of the public in these interest areas.

PI_NAMEs: RAMCHANDRAN, RAMANI  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Address;Advisory Committees;Affect;Basic Science;Blood;Cardiovascular system;career;Clinical;Clinical Research;Communities;Decision Making;Development;Devices;Disease;Educational Curriculum;experience;Exposure to;Faculty;fundamental research;Funding;Goals;Health;Heart Diseases;Hematology;Laboratory Research;Laboratory Study;Leadership;Lung;Manuscripts;Medical;Medical Education;medical schools;Medical Students;Medicine;Mentors;Modality;Modeling;new therapeutic target;next generation;novel strategies;novel therapeutics;Outcome;Pathway interactions;Physicians;Process;programs;Publishing;Qualifying;Regimen;Research;Research Infrastructure;Research Personnel;Research Training;Science;Scientist;Series;student participation;summer research;summer student;Time;Training;training opportunity;Training Programs;Translating;Translational Research;Update;Wisconsin

PROJECT_TITLE: Medical Student Summer Research Training Program


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Our understanding of human health and disease and our capacity to develop disease treatment hinges critically on knowledge of the three-dimensional architectures and functional mechanisms of cellular macromolecules and macromolecular complexes. The terrestrial transcriptome, shaped in part by the action of ribozymes, comprises RNAs and RNA-protein complexes (RNPs) that play major roles in human health and disease. Nevertheless, knowledge of RNA and RNP function and our ability to target them with small molecules remains limited due to challenges in determining their structures and mechanisms at atomic resolution. The Piccirilli laboratory proposes two lines of investigation into noncoding RNA structure and function (1) the development of target- specific synthetic antibodies as crystallization/cryoEM chaperones for obtaining structures of RNAs, RNPs, and their complexes with small molecules, and (2) use of established ribozymes as model systems and new human ribozymes as exploratory targets to develop and apply chemical approaches to achieve deep understanding of how these catalysts shape the terrestrial transcriptome in health and disease.

PI_NAMEs: PICCIRILLI, JOSEPH ANTHONY (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TITLE: Structure and Function of Non-Coding RNA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: HOUSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Coagulation factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) play an essential role in blood coagulation, and their levels are associated with several arterial and venous thrombotic diseases. We will expand our knowledge of the genetics of FVIII and VWF levels in multi-ethnic populations, and explore complex regulatory mechanisms influencing FVIII and VWF levels such as epistasis and epigenetics. Results from this study will lead to a better understanding of the genomic and epigenetic regulation of FVIII and VWF levels and whether they play an independent or coordinated role in the pathology of thrombotic disease, thereby informing the targeted use of existing and novel therapies.

PI_NAMEs: DE VRIES, PAUL STEFAN;MORRISON, ALANNA C (contact);SMITH, NICHOLAS L

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: ABO blood group system;Adhesions;Affect;Aging;Biological;Blood;Blood coagulation;Blood Platelets;Carrier Proteins;Catabolism;Circulation;Coagulation Process;cohort;Complex;Coronary Arteriosclerosis;Data;Development;Endothelial Cells;epigenetic marker;Epigenetic Process;epigenetic regulation;epigenome;epigenome-wide association studies;Ethnic Population;Factor VIII;Fibrin;Gene Silencing;Genes;Genetic;Genetic Determinism;Genetic Epistasis;genetic variant;Genome;genome wide association study;genomic epidemiology;genomic locus;Genomics;Goals;Heart;Hemostatic Agents;Hemostatic function;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Human;improved;In Vitro;in vivo Model;instrument;Ischemic Stroke;Knowledge;Liver;Maps;Measures;Mediating;Mendelian randomization;Methylation;mouse model;multi-ethnic;Myocardial Infarction;novel;novel therapeutics;Outcome;Pathology;Peripheral arterial disease;Phase;Phenotype;Plasma;Play;Population;prevent;programs;Protein Biosynthesis;Research;Resources;Risk;Role;Sample Size;Sampling;Site;Small Interfering RNA;Testing;therapeutic target;Thrombosis;Trans-Omics for Precision Medicine;Umbilical vein;Venous;venous thromboembolism;von Willebrand Factor;whole genome;Work

PROJECT_TITLE: Analysis of Whole Genome Sequence and Hemostasis Phenotypes

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Cachexia;Cancer;Digestive Diseases;Neurosciences;Nutrition;Obesity

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative  Drug treatments to improve health should not cause sickness, pain, or distress. Our reality, however, is that science and medicine are far from achieving this goal. Understanding how disturbances in feeding behavior (e.g., anorexia/hunger loss, nausea/vomiting) and pathological weight loss or gain occur when treating those who suffer from chronic disease requires us to interrogate neurobiological systems out of balance in such conditions.

PI_NAMEs: DE JONGHE, BART C (contact);DOYLE, ROBERT P;HAYES, MATTHEW R

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: 3-Dimensional;Ablation;Affinity;analog;Anorexia;antagonist;Anti-emetics;Antibodies;Appetite Depressants;Area;Attention;Attenuated;Base Sequence;Behavior;Behavioral;Behavioral Assay;behavioral pharmacology;Binding;Biological Assay;Body Weight;Body Weight decreased;Brain Stem;Cachexia;cancer anorexia;cancer therapy;Cell Nucleus;Cells;Cellular Metabolic Process;chemotherapy;Chronic;Chronic Disease;Circulation;Cisplatin;Clinical;Complex;cytokine;Data;Development;Diabetes Mellitus;Disease;Distress;Drug Kinetics;Emetics;Endothelium;energy balance;Equilibrium;experience;Family;feeding;Feeding behaviors;Fluorescent in Situ Hybridization;GDF15 gene;Generations;genomic platform;glial cell-line derived neurotrophic factor;Goals;Health;Human;Hunger;improved;In Vitro;in vivo;in vivo evaluation;inhibitor;Knockout Mice;Lead;Legal patent;Lesion;Link;Literature;Malaise;Malignant Neoplasms;Measures;Mediating;Mediator;Medicine;Metabolic Diseases;Microglia;Modeling;Molecular;Molecular Conformation;Mus;Nausea;Nausea and Vomiting;neural;Neurobiology;Neurons;novel;Obesity;obesity treatment;Output;Pain;Paper;Pathologic;Penetration;Peptides;Peripheral;Pharmacodynamics;Pharmacotherapy;Phenotype;Plasma;Play;Pregnancy;Process;Production;Publishing;rational design;Rattus;receptor;Regulation;Reporting;Research Personnel;response;Rodent;Role;Science;Serum;Shrews;Sick Role;Signal Transduction;Site;Stimulus;Stress;Structure;Structure of area postrema;Syndrome;System;Technology;Testing;Tissues;trafficking;transcriptome;transcriptomics;Vomiting;Weight Gain

PROJECT_TITLE: Targeting the GDF15-GFRAL system to treat nausea and emesis

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: AMHERST

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: The protozoan parasite Toxoplasma gondii latently infects 11-22% of Americans and can cause disease in immunocompromised patients and fetuses. As the parasite traffics through the body where it encounters diverse environment that it must adapt to or will die. The work proposed here is focused on learning how the parasite adapts to these environments with the ultimate goal of developing new therapies and treatments.

PI_NAMEs: BLADER, IRA J (contact);WEST, CHRISTOPHER M.

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Address;Aerobic;American;Amino Acids;Binding Proteins;Biochemical;Biological Assay;Blood;Brain;Calcium;Cell Physiology;Cell Survival;Cells;Cellular Stress;Characteristics;Complex;Cues;CUL1 gene;Cullin Proteins;Cyst;cytokine;Data;Development;Dictyostelium;Differentiation and Growth;Disease;Distant;Environment;Essential Amino Acids;Exposure to;extracellular;F-Box Proteins;Face;Fetus;genome analysis;Goals;Growth;Heart;Homeostasis;human disease;Hydroxylation;Hypoxia;Hypoxia Inducible Factor;Immune response;Immunocompromised Host;In Vitro;in vivo;Infection;Interferon Type II;Knowledge;Learning;Life;Ligase;Lung;Mediating;Medical;Metabolic;Modification;Muscle;mutant;Names;new therapeutic target;novel therapeutics;Nutrient;Organism;Oxygen;Parasites;pathogen;Pathway interactions;Peptide Elongation Factor 2;Phosphorylation;Phosphotransferases;phyA phytochrome;phyB phytochrome;Polyubiquitin;Procollagen-Proline Dioxygenase;Proliferating;Proline;Protein Biosynthesis;Proteins;Proteome;Protozoa;Publishing;RBX1 gene;recruit;Resistance;response;Retina;Shapes;Stream;Stress;Testing;Tissues;Toxoplasma;Toxoplasma gondii;transcription factor;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Virulence;Work

PROJECT_TITLE: Protist Oxygen Sensing in Human Disease Protist Oxygen Sensing in Human Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-L(02)]


NIH_SPENDING_CATS: Genetics;Immunotherapy

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE / PUBLIC HEALTH RELEVANCE Inflammation and immunity play dominant roles in physiological processes critical to controlling pathologies associated with infectious agents and cancer. Furthermore, immune deregulation can lead to autoimmune or immunodeficiency disorders. Major gaps exist in our understanding of the complex immunoregulatory network that controls these mechanisms. Therefore, increased understanding of the intricate signaling mechanisms central to coordinating these immunomodulatory responses is critical for designing effective immuno- and pharmacotherapies to combat disease.

PI_NAMEs: LIPSCOMB, MICHAEL W (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: allograft inflammatory factor-1;Antigen Presentation;Autoimmune Diseases;autoreactive T cell;Biology;Calcium;Calcium Signaling;Cells;combat;Complex;Coupled;Cyclic AMP-Dependent Protein Kinases;Dendritic Cells;design;Disease;Generations;Genes;Goals;Health;Hematopoiesis;Hematopoietic stem cells;Immune;Immune response;Immunity;Immunobiology;Immunologic Deficiency Syndromes;immunoregulation;Immunotherapy;in vivo;Infectious Agent;Inflammation;innovation;insight;insulitis;Knockout Mice;Knowledge;Laboratories;Macrophage;Malignant Neoplasms;Molecular;molecular mechanics;monocyte;Myeloid Cells;novel;pathogen;Pathology;Pharmacotherapy;phosphoric diester hydrolase;Physiological Processes;Play;Process;Protein Kinase C;Proteins;public health relevance;Publishing;recruit;Research;response;RNA Interference;Role;scaffold;screening;selective expression;Signal Transduction;success;T cell response;Tissues;tool;transcriptomic profiling;Work

PROJECT_TITLE: Deciphering the immunoregulatory network governing antigen presenting myeloid cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative In the United States, 60% of adults have at least one chronic disease such as heart disease, cancer, and diabetes and 40% have two or more. Although research has identified genomic signatures of common diseases, these genomic risk assessments are not used in clinical care to identify, and if appropriate, pre-treat patients at high risk for developing disease. Establishing methods to implement genomic risk assessment and management in clinical care is the vital first step to leverage the power of genomics to prevent disease.

PI_NAMEs: CIMINO, JAMES J;LIMDI, NITA A (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Accounting;Adherence;Adopted;Adult;African American;African ancestry;Alabama;American;Asian;biobank;Blood Glucose;Body mass index;Cause of Death;Cessation of life;Cholesterol;Chronic Disease;Clinic Visits;Clinical;clinical care;Clinical Data;clinical decision support;Clinical Trials;cohort;Collaborations;Communication;Complex;Consent;Data;Development;Diabetes Mellitus;digital;disability;Disease;Disease Management;disorder risk;Education;Educational Materials;Environment;ethical, legal, and social implication;European;Evaluation;experience;Family;Family history of;gene interaction;Genes;Genetic;genetic architecture;genome wide association study;genomic signature;Genomics;Genotype;Health;Health Care Costs;health disparity;health record;Heart Diseases;high risk;Hispanic;implementation outcomes;improved outcome;indexing;Individual;Informatics;Life Style;Link;Malignant Neoplasms;Medical;medically underserved;medically underserved population;Methodology;Methods;Minority Health Research;Modification;Morbidity - disease rate;mortality;Outcome;Participant;Patients;Phenotype;phenotypic data;phenotyping algorithm;polygenic risk score;Population;Population Heterogeneity;Practice Guidelines;Prevalence;prevent;prospective;Public Health;Publications;Race;racial minority;racial minority population;racial population;Recommendation;Recording of previous events;recruit;Reporting;Research;Research Design;Risk;Risk Assessment;Risk Estimate;Risk Management;Risk Reduction;Sample Size;Sampling;Specific qualifier value;statistics;tool;Trust;Underrepresented Minority;underserved community;United States;uptake;visit adherence

PROJECT_TITLE: Integrating Genomic Risk Assessment for Chronic Disease Management in a Diverse Population


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: GAINESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative The proposed research is relevant to public health because it can result in enhanced perioperative care workflow and early intervention, ultimately improving patient outcomes and decreasing hospitalization costs. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to advancing disease diagnosis through medical applications of new tools and technologies, as the proposed research applies advanced computational methods to compute the risk of postoperative complications in real-time.

PI_NAMEs: BIHORAC, AZRA  (contact);RASHIDI, PARISA

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acceleration;Address;Adopted;advanced disease;Algorithms;American;Artificial Intelligence;artificial intelligence model;Artificial Intelligence platform;Behavioral;Benchmarking;Black Box;Bridge to Artificial Intelligence;Caring;Clinical;clinical implementation;Clinical Research;Clinical Trials;Cognitive;Collaborations;collaborative approach;Complication;computerized tools;Computing Methodologies;Critical Care;Data;data integration;data modeling;Data Pooling;Data Set;data sharing;data streams;disease diagnosis;distributed data;Early Intervention;effectiveness evaluation;Environment;Ethics;Evaluation;explainable artificial intelligence;federated learning;Florida;Foundations;Funding;Generations;Health;high risk;Hospital Costs;Hospitalization;Hospitals;Human;human centered computing;improved;Informatics;Infrastructure;innovation;Institution;interoperability;Investments;Legal patent;Machine Learning;machine learning algorithm;Medical;Mission;Modeling;multimodal data;multimodality;novel;operation;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;Performance;Perioperative Care;Physicians;Physiological;Population Heterogeneity;Postoperative Complications;preference;Prevention strategy;Privacy;privacy preservation;Process;Productivity;programs;prospective;prospective test;Psyche structure;Public Health;Publications;Reproducibility;Research;Risk;Risk Assessment;risk mitigation;Science;social health determinants;success;surgical risk;System;Technology;Testing;theories;theory of mind;Time;tool;Training;Trust;trustworthiness;United States;United States National Institutes of Health;Universities;usability;Validation;Work

PROJECT_TITLE: Explainable, Fair, Reproducible and Collaborative Surgical Artificial Intelligence: Integrating data, algorithms and clinical reasoning for surgical risk assessment (XAI-IDEALIST)

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: WORCESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Narrative:  Circadian rhythms play a critical role: they optimize metabolism, physiology and behavior with the time-of-day. Our goal is to uncover the basic molecular and cellular mechanisms governing circadian rhythms and an important complex behavior they control, sleep. To this end, we use Drosophila because this model organism has proven to be particularly potent to reveal fundamental and conserved mechanisms underlying circadian clocks and sleep. Thus, we anticipate that our work will ultimately impact our understanding of diseases and ailments linked to circadian rhythm and sleep disruptions.

PI_NAMEs: EMERY, PATRICK  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Animals;Behavior;Behavior Control;Biological;Biological Clocks;circadian;circadian pacemaker;circadian regulation;Circadian Rhythms;Compensation;Complex;Cyanobacterium;Disease;Drosophila genus;Drosophila melanogaster;Eating;Ensure;Environment;Eukaryota;Feedback;fungus;Genetic Transcription;Goals;Health;Human;Incidence;innovation;Link;Malignant Neoplasms;Mammals;Messenger RNA;Metabolic Diseases;Metabolism;model organism;Modeling;Molecular;Mood Disorders;neural;Neuroglia;neuromechanism;Organism;Output;Periodicity;Personal Satisfaction;Physiology;Planet Earth;Plants;Play;Post-Translational Protein Processing;posttranscriptional;Property;Role;Sleep;Sleep disturbances;Study models;System;Temperature;Time;Variant;Work

PROJECT_TITLE: Molecular and cellular mechanisms underlying circadian rhythms and sleep in Drosophila


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Narrative Thyroid hormone (TH) is a critical mediator of fetal development and then essential for normal health during adulthood. Currently, therapy for those with hypothyroidism (either congenital or acquired later in life) is with L-thyroxine and many individuals on therapy do not feel adequately replaced, in this proposal we put forward experiments designed to develop thyroid hormone secreting follicular cells from human induced pluripotent stem cells. Completion of this work will give us significant insight into the developmental biology of the human thyroid and potentially offer a unique and powerful approach to treat hypothyroidism in humans, furthermore, the development of follicular cells from progenitor cells will give us an ideal model to better understand many diseases of the thyroid that affect human health.

PI_NAMEs: HOLLENBERG, ANTHONY N (contact);KOTTON, DARRELL N.

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: Adult;Affect;Anterior;Area;Attention;Biological Assay;Birth;BMP4;Bone Morphogenetic Proteins;Cell Line;Cell Lineage;cell replacement therapy;Cell Therapy;Cell Transplantation;cell type;Cells;Clone Cells;Computer Models;Cretinism;Defect;Derivation procedure;Development;Developmental Biology;differentiation in vitro;directed differentiation;DNA Sequence Alteration;embryonic stem cell;Endoderm;Engineering;Ensure;epithelial stem cell;Experimental Designs;Fetal Development;FGF2 gene;Fibroblast Growth Factor;Future;gene network;gene regulatory network;Genes;Genetic Processes;Goals;Growth Factor;Health;Heterozygote;Hormone replacement therapy;Hormone secretion;Human;Human Biology;human disease;human induced pluripotent stem cells;human model;Hypothyroidism;immunodeficiency;Immunodeficient Mouse;in utero;In Vitro;in vivo;in vivo regeneration;Individual;induced pluripotent stem cell;insight;Lead;Life;Longevity;Mediator;Methodology;Modeling;molecular phenotype;Mouse Embryonic Stem Cells;Mus;mutant;Mutation;mutation correction;Natural regeneration;novel;Organoids;overexpression;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pluripotent Stem Cells;Population;pre-clinical;preclinical development;Primitive foregut structure;Process;Production;progenitor;Quantitative Evaluations;Rana;reconstitution;Regenerative capacity;regenerative cell;regenerative therapy;Reporter;Resolution;Role;Safety;Signal Transduction;single-cell RNA sequencing;stem cell based approach;stem cell technology;stem cells;success;Testing;Therapeutic;Thyroid Diseases;Thyroid Function Tests;Thyroid Gland;Thyroid Hormones;Thyroxine;Tissues;transcription factor;Transplantation;volunteer;Work

PROJECT_TITLE: Thyroid Follicular Cell Signaling and Development in Humans

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: PROJECT NARRATIVE Our proposed research will identify fuels, such as ketone bodies, that support and direct different protective T cell lineages, as well as the system-level processes that control availability of these fuels. By defining how protective immune responses to infection are supported and directed by ketone body metabolism, the proposed research could be transformative, allowing us to better understand, treat, and prevent infectious diseases. Findings from these studies will provide a springboard for immunometabolic therapeutic research, opening new horizons for leveraging diet—such as exogenous metabolite supplementation or caloric restriction—to regulate host immune response to infection, ultimately boosting host defense and/or enhancing immunization effectiveness.

PI_NAMEs: JONES, RUSSELL  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Acetoacetates;Acetyl Coenzyme A;acute infection;adaptive immunity;Adenosine Triphosphate;Animals;Bacteria;beta-Hydroxybutyrate;Bioenergetics;Blood;Caloric Restriction;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Lineage;cell mediated immune response;Cell Physiology;Cells;Cellular Metabolic Process;Circulation;Citric Acid Cycle;Communicable Diseases;Communities;Couples;cytokine;Data;Diet;Diet Modification;dietary;Dietary Intervention;Drops;Effectiveness;effector T cell;Enzymes;Epigenetic Process;Esters;Fasting;fighting;Gene Expression;Genetic Transcription;Glucose;Goals;Histone Acetylation;histone modification;Host Defense;Immune response;Immunity;Immunization;immunoregulation;In Vitro;in vivo;Infection;Interferon Type II;Intervention;Ketone Bodies;Ketones;Knock-out;Knowledge;Listeria;Listeriosis;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Mediating;Memory;Metabolic;Metabolism;Mitochondria;Modeling;mouse model;Mus;novel;opportunistic pathogen;Outcome;pathogen;Pathogenicity;Pathway interactions;pharmacologic;Phase;prevent;Primary Infection;Process;Production;Research;response;Role;Stable Isotope Labeling;Supplementation;System;T cell differentiation;T cell response;T-Cell Activation;T-Lymphocyte;Techniques;Testing;Therapeutic Research;vaccination strategy;Virus

PROJECT_TITLE: Ketone Body Metabolism in CD8+ T Cell Responses

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: The problems associated with an aging society transcend the boundaries of any specific discipline and play out across multiple biologic and societal domains ranging from individual cells to national and world economies. The six National Institute on Aging center programs address important topics in aging but typically from a specific disciplinary perspective. The objective of the Research Centers Coordinating Network is to initiate new cross‐disciplinary collaborative networks that bring together key thought leaders from each of the 6 NIA centers programs to align approaches across programs that will uncover synergies and insights leading to novel collaborations.

PI_NAMEs: KRITCHEVSKY, STEPHEN B. (contact);LEDERMAN, STEPHANIE

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Achievement;Address;Affect;Aging;aging related disease;Alzheimer's Disease;American;Archives;Award;Behavioral Sciences;Biological;Biology of Aging;Body System;career;Cells;Clinical Research;Clinical Trials;Collaborations;Communities;Competence;Complex;demographics;design;Development;Discipline;Disparity;Economics;Education;Educational workshop;Evaluation;Event;Fostering;Foundations;Future;Geriatrics;Goals;Grant;Guidelines;Health Services Accessibility;improved;Individual;innovation;insight;Institution;interdisciplinary approach;Interdisciplinary Study;interest;Internet;Intervention Trial;Knowledge;Manuscripts;medical schools;multidisciplinary;National Institute on Aging;Neurologic;novel;older adult;Organ;Persons;Play;prevent;Process;programs;prototype;psychologic;Publications;recruit;Research;Research Personnel;Research Support;Resources;Scholars Program;Science;Scientific Advances and Accomplishments;Series;Societies;Structure;support network;symposium;synergism;tool;training opportunity;Transcend;treatment effect;Twitter;web portal;webinar;Work

PROJECT_TITLE: Research Centers Collaborative Network Renewal

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative- Longworth, Michelle S. The de-repression of retrotransposable elements (RTEs) within the human genome leads to upregulation of Type I IFNs which can cause cell death, and this is currently being explored as a potential mechanism to kill cancer cells, in combination with immune checkpoint inhibitors. We discovered that condensin complexes are necessary for the ability of RTEs to induce IFN in epithelial cells (the most common cell type that develops into solid tumors), and in this proposal, we will determine how RTE expression influences condensins to promote Type I IFN induction and uncover novel roles for condensins in RTE-mediated innate immune signaling responses. Results will expand our knowledge of how RTEs activate innate immune responses, and identify new pathways that can be modulated to enhance cancer therapies that rely on RTE-mediated IFN induction to kill cancer cells.

PI_NAMEs: LONGWORTH, MICHELLE S (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: 3' Untranslated Regions;Binding;Biological Assay;cancer cell;cancer therapy;candidate selection;Cell Death;Cell Line;cell type;Cells;Complex;condensin;CRISPR/Cas technology;Cytoplasm;Data;derepression;Development;DNA Damage;Elements;Engineering;Epithelial Cells;Feedback;Foundations;Future;Genes;Genetic Transcription;Genome;Human Genome;Immune checkpoint inhibitor;Immune signaling;inhibitor;Innate Immune Response;Interferon alpha;Interferon Type II;Interferons;knock-down;Knowledge;Ligation;Long Interspersed Elements;Malignant Neoplasms;Mediating;microbial products;mutant;novel;novel therapeutics;Nuclear;Nucleic Acids;Outcome;Pathway interactions;Pattern recognition receptor;Proteins;receptor;Receptor Signaling;repaired;Repression;response;Retroelements;Retrotransposition;Retrotransposon;RNA;Role;Signal Induction;Signal Transduction;Solid Neoplasm;Testing;therapeutic development;Transfection;Translations;Tretinoin;Tumor-Derived;Up-Regulation;Viral;Work

PROJECT_TITLE: Interplay between LINE-1 retrotransposons, condensins, and IFN

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative All organisms continuously perceive and evaluate nutrient availability, demand, and palatability. Recent research has shown that homeostatic drives are as influential in this process as are pleasurable experiences, and our work using the fruit fly, Drosophila melanogaster, has established that aging is modulated by these motivational states. Our proposed studies will dissect the molecular mechanisms through which neural states of feeding motivation influence aging and physiology in flies to illuminate how similar processes may control healthy aging in mammals.

PI_NAMEs: PLETCHER, SCOTT  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acute;Affect;age-related disease;Aggressive behavior;Aging;aging mechanism;aging related;alpha ketoglutarate;Amino Acids;Behavior;Behavioral;Biological Models;Biology of Aging;Brain;Branched-Chain Amino Acids;Caenorhabditis elegans;Cells;Chemosensitization;Chromatin;Citric Acid Cycle;Complex;Consumption;Coupled;Creativeness;Data;Decision Making;Dementia;Diet;dietary;dietary manipulation;Disease;Drosophila genus;Drosophila melanogaster;Eating;Economics;Elderly;Engineering;Environment;epigenetic regulation;Etiology;Evaluation;Event;experience;extend lifespan;feeding;Feeding behaviors;fly;Food;food environment;Food Preferences;Fright;functional decline;Genes;Genetic;Genetic Transcription;Goals;Growth;Health;Health Benefit;Health Promotion;healthy aging;hedonic;Histone H3.3;HTR2A gene;Human;Hunger;Influentials;innovation;innovative technologies;insight;Insulin;Intervention;Life;life span;Longevity;Malignant Neoplasms;Mammals;Measures;Metabolic;Metabolism;model organism;Modification;Molecular;motivated behavior;Motivation;Mus;Nature;Nerve;neural;neural circuit;Neurobiology;neuronal circuitry;Neurons;Neurosciences;novel;Nutrient;Nutrient availability;Nutritional;optogenetics;Organism;Partner in relationship;Pathology;Pathway interactions;Peripheral;Personal Satisfaction;Physiological;Physiology;Play;Population;Prevalence;Process;Reaction;Research;response;Rewards;Risk Factors;Role;Saccharomyces cerevisiae;Satiation;screening program;Serotonin;serotonin receptor;Serotonin Receptor 5-HT2A;Signal Pathway;Signal Transduction;Sirtuins;Societies;Starvation;System;Techniques;Technology;Testing;Tissues;tool;Work

PROJECT_TITLE: Modulation of aging through mechanisms of nutrient demand and reward

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ORG_CITY: CHAPEL HILL

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative To develop Allergists and Immunologists and PhD scientists optimally trained in translational research and fully prepared to pursue independent academic careers by capitalizing on the training infrastructure of two leading Universities: The University of North Carolina and Duke.

PI_NAMEs: PEDEN, DAVID B. (contact);SLEASMAN, JOHN W.

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Research Training in Allergy and Clinical Immunology

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative The proposed research will employ cutting-edge eye tracking methods to investigate fine-scale eye movement differences in psychosis, a topic that has barely been explored. Such an investigation constitutes an important first step towards characterizing the psychosis phenotype, which in turn could clarify the pathophysiology of psychosis and generate new methods for differential diagnosis. The proposed research will also provide a potentially new explanation of visual acuity and reading deficits in psychosis. This explanation, once established, can suggest new treatments and interventions for psychosis patients who exhibit poor acuity or reading ability.

PI_NAMEs: KEANE, BRIAN PATRICK;POLETTI, MARTINA  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Adult;attentional bias;biobehavior;Calibration;caudate nucleus;Cerebellar vermis structure;Characteristics;clinical predictors;Complex;Custom;Data Collection;Differential Diagnosis;digital;Disparate;Dorsal;Dyskinetic syndrome;Exhibits;Eye;Eye Movements;Facial Expression Recognition;Frequencies;frontal eye fields;Functional disorder;Future;gaze;Goals;Head;Helmet;Image;Impairment;improved;interest;Intervention;Investigation;Lateral;Letters;Light;Literature;Measurement;Methods;Motion;neural;novel;oculomotor;oculomotor behavior;Patients;Perception;Persons;Phenotype;Population;Positioning Attribute;Prefrontal Cortex;prevent;Procedures;Process;Psychoses;Psychotic Disorders;PubMed;Reading;reading ability;reading difficulties;Reporting;Research;Resolution;Retina;retinal imaging;Saccades;sample fixation;Sample Size;Schizophrenia;Speed;statistics;Stimulus;Structure;System;tool;Vision;Visual;Visual Acuity;Visual impairment;visual tracking;Writing

PROJECT_TITLE: Fine-scale eye-movement differences in psychosis and their contribution to abnormal vision

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Immunotherapy;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: O’Brien R50 Research Specialist (Clinician Scientist) Project Narrative Funding of Dr. O’Brien’s research efforts within the NCTN Children’s Oncology Group (COG) will contribute to advances in the treatment of children, adolescents, and young adults with acute lymphoblastic leukemia (ALL) through the evaluation of novel targeted therapies with the goal of improving efficacy and decreasing short and long-term toxicities. Over the next decade, the COG ALL committee aims to optimize the incorporation of immune-based therapies including blinatumomab, inotuzumab ozogamicin, and chimeric antigen receptor T-cell therapy as well as evaluate genomically targeted therapies in specific patient subgroups. Pharmacogenomic studies will be critical to identifying predictors of toxicity and response and tailoring therapy with both conventional and novel agents across diverse populations.

PI_NAMEs: O'BRIEN, MAUREEN MEGAN (contact)

PROGRAM_OFFICER_NAME: MAHER, MOLLY ELIZABETH

PROJECT_TERMS: Acute Lymphocytic Leukemia;Adolescent and Young Adult;Antibodies;Antibody-drug conjugates;Apoptosis;Biology;CAR T cell therapy;Child;Child Care;Child Development;Childhood;Childhood Acute Lymphocytic Leukemia;Clinical;Clinical Research;Clinical Trials;design;Development;Evaluation;experience;Funding;Genomics;Goals;high risk;Immunotherapy;improved;improved outcome;individualized medicine;interest;kinase inhibitor;Lead;leukemia;leukemia relapse;leukemia treatment;leukemia/lymphoma;Medical center;member;Molecular;National Clinical Trials Network;new therapeutic target;Newly Diagnosed;Newly Diagnosed Disease;novel;novel therapeutics;Outcome;patient population;patient subsets;Patients;Pediatric Hospitals;Pediatric Oncologist;Pediatric Oncology Group;Pharmacogenomics;Physician Executives;Pilot Projects;Population;Population Heterogeneity;precision medicine;programs;Relapse;Research;response;Scientist;screening;side effect;Specialist;targeted agent;targeted treatment;Time;Toxic effect

PROJECT_TITLE: Pediatric acute lymphoblastic leukemia: Improving outcomes through incorporation of novel targeted therapies into treatment for relapsed and newly diagnosed disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (J1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

ORG_CITY: DEARBORN

ORG_NAME: UNIVERSITY OF MICHIGAN AT DEARBORN

PHR: Project Narrative Macrophages, a type of immune cells, capture microbial pathogens in vesicles known as phagosomes, which are gradually filled with acid as they move towards the center of the immune cell where they fuse with another vesicle known as the lysosome for pathogen elimination. The goal of our proposal is to elucidate how the acid in the phagosome lumen governs the transport of the phagosome. Pathogens that cause severe diseases in humans employ various mechanisms to subvert phagosomal acidification, and therefore insights gained from this study will have significant implications for developing effective methods to combat these highly dangerous microbes.

PI_NAMEs: KONDAPALLI, KALYAN C (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Acids;Bacteria;Binding;Biophysics;Candida;Capsid Proteins;Cell fusion;Cell Line;Cell membrane;Cells;Cholesterol;combat;Communication;Confocal Microscopy;Dangerousness;Data;Disease;Dissociation;Dynein ATPase;Early Endosome;Engineering;Environment;Enzyme Precursors;Equilibrium;experimental study;Extravasation;fluorophore;Generations;Genus Mycobacterium;Goals;Health;Host Defense;Human;image visualization;Immune;Immunofluorescence Microscopy;Impairment;insight;Ions;Kinesin;late endosome;Ligands;Light;Link;Lipids;Liquid substance;live cell imaging;Lysosomes;Macrophage;Maps;Mass Spectrum Analysis;Measurement;mechanical properties;Mechanics;Mediating;Membrane;Membrane Lipids;Methods;Microbe;Microscopy;Microtubules;Molecular Motors;Monitor;Monte Carlo Method;Motility;Motion;Motor;Motor Activity;Movement;mutant;novel strategies;Nuclear;optic trap;optical traps;Organelles;Outcome;pathogen;pathogenic microbe;Pathway interactions;Peroxides;Phagocytes;Phagocytosis;Phagosomes;phosphatidylinositol 3-phosphate;Play;Process;Proteins;Proton Pump;Protons;Publishing;receptor;recruit;Regulation;Research;Role;Salmonella;Side;Sodium;stem;Techniques;Testing;Vesicle;Work

PROJECT_TITLE: Elucidating the role of luminal pH in regulating phagosome transport

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-X (SU)]


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: JACKSONVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NORTH FLORIDA

PHR: Project Narrative Many children with cerebral palsy are often deprived of participation in life activities given limited postural control and walking capabilities, leading to delayed development and low quality of life. Ride-on power mobility devices allow for the self-generated, active control of mobility, with a novel stand-on ride-on device providing an additional support to maintaining upright posture to improve children’s balance and lower extremity strength. Our proposal will be the first study to evaluate biomechanical factors underlying expected changes in balance and mobility function after stand-on ride- on device use and generate fundamental knowledge to guide subsequent intervention work to enhance functional outcomes.

PI_NAMEs: CESAR, GUILHERME MANNA (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: active control;Address;Age;Applications Grants;Area;Attention;balance testing;Biomechanics;Case Series;Case Study;Cerebral Palsy;Characteristics;Child;Classification;Clinical Research;cohort;Coupling;Data;Development;Devices;Early Intervention;equilibration disorder;Equilibrium;falls;Family;Fostering;functional outcomes;Gait;Gastrocnemius Muscle;Goals;Health;improved;Individual;Individuals with physical disabilities;Injury;Intervention;kinematics;Kinetics;Knowledge;Life;Limb structure;Literature;Lower Extremity;Measures;Medical;Medical center;mobility aid;Mobility decline;Modification;Motor;Motor disability;Movement;Muscle;Musculoskeletal Equilibrium;National Institute of Child Health and Human Development;National Institute of Neurological Disorders and Stroke;Neurologic;novel;Outcome;Pattern;peer;Pelvis;Physical activity;physically handicapped;Play;Population;post intervention;Posture;prepuberty;pressure;psychosocial development;Public Health;quadriceps muscle;Quality of life;Reaction;Recommendation;recruit;rehabilitation research;Research;Research Priority;Role;Sampling;Socialization;Societies;spatiotemporal;Strategic Planning;Structure;System;Technology;Testing;Time;United States National Institutes of Health;Walking;Weight;Work

PROJECT_TITLE: Biomechanical Changes Underpinning Stand-on Ride-on Power Mobility Devices for Children with Cerebral Palsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-G (02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Services;Heart Disease;Palliative Care

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Over 280,000 people die from advanced heart failure each year in the United States. Clinical practice guidelines strongly recommend specialist palliative care for people with advanced heart failure to help address their many palliative care needs, however, few receive this vital service. Using mixed methods, this project will identify strategies that increase access to specialist palliative care and improve care near the end of life, findings that can inform the policies and care practices of palliative and cardiology programs nationwide, and improve the care of people with advanced heart failure.

PI_NAMEs: FEDER, SHELLI LEORE (contact)

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: Address;Administrator;Cardiology;care delivery;care outcomes;Caring;Cessation of life;Characteristics;Clinical Practice Guideline;Consultations;Country;Data;data infrastructure;Data Set;deviant;Dimensions;Electronic Health Record;end of life;end of life care;end of life outcomes;experience;Family;Family member;Frequencies;Funding;Goals;Healthcare;Healthcare Systems;Heart Diseases;Heart failure;Hematological Disease;Home;Hospice Care;hospice environment;hospice utilization;Hospitalization;implementation evaluation;implementation facilitation;implementation strategy;improved;innovation;insight;Interview;Investigation;Joints;Knowledge;Life;Logistic Models;Lung Diseases;Medical center;Medicare/Medicaid;Methods;novel;Outcome;palliative;Palliative Care;Patient Care;Persons;Policies;Population;Process;programs;Quality of Care;Recommendation;Reporting;Research;Risk Adjustment;Sampling;satisfaction;Services;Site;Sleep Disorders;Specialist;Standardization;Structure;structured data;Surveys;Symptoms;Time;United States;United States Department of Veterans Affairs;Variant;Workload

PROJECT_TITLE: Identifying Successful Strategies of Specialist Palliative Care Implementation for People with Advanced Heart Failure

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: FLUSHING

ORG_DEPT: PSYCHOLOGY

ORG_NAME: QUEENS COLLEGE

PHR: Although environmental enrichment is proving to be an effective treatment for substance use disorder, almost nothing is known about the behavioral and brain mechanisms by which it is effective. A better understanding of these mechanisms would aid in the development of improved neurobiological and behavioral treatments. The proposed studies are aimed at investigating this.

PI_NAMEs: RANALDI, ROBERT  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Abstinence;abuse victim;addiction;Adolescent;Anhedonia;Animals;Behavior;Behavior Therapy;Behavioral;Behavioral Mechanisms;Brain;Chronic;Clinical;Cognition;Consumption;Cues;Darkness;Data;Development;Disease;Dopamine;dopamine system;dopaminergic neuron;Drug Addiction;drug craving;drug reward;Drug usage;Drug Use Disorder;DSM-V;effective therapy;environmental enrichment for laboratory animals;Epidemic;experience;Exposure to;Extinction;Female;Fiber;Health;Heroin;Heroin Abuse;heroin use;Human;improved;In Situ Hybridization;Light;long term abstinence;male;Measures;Medial;Modeling;mu opioid receptors;negative affect;neural;neuroadaptation;Neurobiology;neuromechanism;non-drug;Nucleus Accumbens;Opioid;opioid abuse;opioid use;overdose death;Pharmaceutical Preparations;Photometry;preference;Prefrontal Cortex;Rattus;receptor;Relapse;relapse prevention;Reporting;response;Rewards;Saline;Schedule;Self Administration;Stress;Substance Use Disorder;substance use treatment;System;Testing;therapy development;Training;treatment strategy;Ventral Tegmental Area;Visualization;Western Blotting

PROJECT_TITLE: Environmental enrichment reverses heroin-caused neural and behavioral adaptations in rats

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-W (SU)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE The research program of this center focuses on the impact of substance use on risk for, development, and progression of chronic diseases. Better understanding of this relationship is expected to benefit individuals with substance use disorders and/or chronic diseases. The center’s projects are led by early career scientists to prepare them for advanced research careers in service of public health.

PI_NAMEs: MONTI, PETER M. (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: addiction;Affect;Alcohol consumption;anxiety symptoms;Applications Grants;Area;Award;biobehavior;biopsychosocial;Businesses;Cannabis;career;career development;Centers of Research Excellence;Child;Chronic Disease;Clinical;clinically relevant;cohort;commune;Communities;Community Health;cost effectiveness;Development;digital;Disease;disorder risk;Enrollment;Environment;ethnic health disparity;Evaluation;experience;Faculty;faculty mentor;Fostering;Funding;Goals;Health;health disparity;high risk;Human Resources;Human Subject Research;Individual;Infrastructure;innovation;insight;Interdisciplinary Study;interest;intergenerational;Intervention;Knowledge;Laboratories;Lead;Learning;life course persistent;Life Cycle Stages;Link;longitudinal, prospective study;Manuscripts;marijuana use;Measures;member;Mental Health;Mentors;Mentorship;mid-career faculty;mood symptom;multidisciplinary;Needles;next generation;Nicotine;novel;Obesity;organizational structure;Outcome;Peer Review;people of color;perinatal period;Persons;Phase;Physiological;Pilot Projects;pregnant;Prevention;Productivity;programs;public health relevance;Publications;Publishing;racial health disparity;recruit;Reproducibility;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Rhode Island;Risk;Risk Factors;Science;Scientist;Services;shared database;Smoke;Smoking;social health determinants;socioeconomics;stress symptom;substance use;Substance Use Disorder;success;Technology;Translational Research;United States National Institutes of Health;United States Public Health Service;Universities;Weight;Work

PROJECT_TITLE: Center for Addiction and Disease Risk Exacerbation

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (C2)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PI_NAMEs: AHLUWALIA, JASJIT SINGH (contact)

PROJECT_TERMS: addiction;Address;Advisory Committees;alcohol abuse therapy;alcohol and other drug;Alcohols;ARHGEF5 gene;biopsychosocial;career;career development;Centers of Research Excellence;Chronic Disease;Clinical;Communities;Complement;design;Development;Development Plans;Disease;disorder risk;Doctor of Philosophy;early-career faculty;Educational workshop;Effectiveness;Ensure;ethnic minority;Evaluation;experience;Faculty;Feedback;Funding;Goals;Grant;Health;health disparity;high risk population;Hospitals;improved;Individual;innovation;Institution;interest;International;Investments;Journals;Laboratories;Leadership;Link;member;Mentors;Minnesota;minority communities;minority health;minority health disparity;Monitor;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;National Institute on Minority Health and Health Disparities;Nicotine Dependence;organizational structure;Phase;Physicians;Pilot Projects;Postdoctoral Fellow;Principal Investigator;programs;Psychologist;racial minority;recruit;Research;Research Ethics;Research Personnel;Research Project Grants;Research Training;Resources;Risk;Science;Scientist;Secure;senior faculty;Series;substance use;success;Training;Training Programs;Underrepresented Populations;underserved community;Underserved Population;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Prevention

PI_NAMEs: TIDEY, JENNIFER W. (contact)

PROJECT_TERMS: Achievement;addiction;Adverse event;Area;base;biobehavior;Biological;Biological Assay;Biological Markers;biopsychosocial factor;Blood;Businesses;career;Centers of Research Excellence;Chronic Disease;Clinical;Clinical Management;Collaborations;Communities;Complement;Consumption;Contracts;cost;COVID-19 pandemic;Data;Data Collection;data management;Databases;design;Development;Diagnostic;disorder risk;eligible participant;Ensure;Equipment;Equipment and supply inventories;Fee-for-Service Plans;follow-up;Funding;Future;Hospitals;Human Subject Research;Hybrids;Immunoassay;innovation;Institution;Institutional Review Boards;instrument;interest;Laboratories;laboratory experience;Leadership;Link;Longitudinal Studies;Maintenance;Measures;Medical History;Methodology;Mission;Modeling;Monitor;Outcome;Participant;participant safety;Patient Recruitments;Persons;Phase;Physiological;Procedures;Process;Productivity;prospective;Public Health Schools;Questionnaires;Recovery;Reproducibility;Research;Research Design;Research Personnel;Research Support;Resources;Risk;Risk Factors;Sampling;Scientist;secondary analysis;Service delivery model;Services;Spanish;substance use;sustainable resource;System;Testing;Time;Training;Translating;Universities;uptake;Work

PROJECT_TITLE: Clinical Laboratory Core (CLC)


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PI_NAMEs: WRAY, TYLER BLAKE (contact)

PROJECT_TERMS: Acceleration;addiction;Address;Advertising;Area;Basic Science;Black race;Budgets;Charge;Chronic Disease;Clinic;Clinical Research;Clinical Trials;Communities;community advisory board;community clinic;community engaged research;Community Health;community organizations;Community Outreach;Complex;Consultations;cultural competence;design;digital;disorder risk;Elements;Enrollment;Ensure;Equity;ethnic minority;ethnic minority population;Exclusion;experience;Goals;Health Care Costs;health disparity;Health Personnel;Hispanic;Hour;Human Resources;Individual;Internet;Intervention;Knowledge;Latino Population;Lead;Literature;Marketing;media use;Mediation;Medical;meetings;member;Methods;Minority Groups;Modernization;Monitor;Not Hispanic or Latino;Organizational Culture;outreach;Participant;Pathway interactions;Patient Recruitments;Patients;Performance;Persons;Phase;Pilot Projects;Population;Population Heterogeneity;Procedures;Process;prospective;Provider;Public Health;racial minority;racial minority population;Recovery;recruit;Registries;Regulation;Relationship-Building;Reporting;Research;Research Activity;Research Personnel;research study;Resource Sharing;Resources;Rhode Island;Sampling;Science;Services;skills;social media;Substance abuse problem;substance use;Substance Use Disorder;System;Technology;Time;Training;Treatment outcome;treatment research;Trust;Underserved Population;web site;Work

PROJECT_TITLE: Recruitment, Engagement, and Community Health (REACH) Research Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse;Tobacco;Tobacco Smoke and Health

PI_NAMEs: MURPHY, CARA  (contact)

PROJECT_TERMS: Abdomen;addiction;Adherence;African American population;Alaska Native;American Indians;Area;Behavioral;Biological Markers;Black race;blood glucose regulation;Blood Pressure;Carbon Monoxide;Cardiovascular Diseases;Central obesity;Cessation of life;Cigarette;cigarette smoke;cigarette smoking;CLC Gene;Clinical;clinical practice;Clinical Research;Clinical Trials;clinically relevant;Collection;combustible cigarette;Data;data management;design;Desire for food;Development;Devices;Diabetes Mellitus;disability;Disease;disorder risk;Educational Status;Electronic cigarette;Energy Intake;Exhalation;Fatty acid glycerol esters;FDA approved;Feasibility Studies;follow-up;Fright;Future;Grant;Harm Reduction;Health;high risk;improved;Individual;Inflammation;Insulin Resistance;Knowledge;Life Expectancy;lipid metabolism;Low income;Measures;Mediation;Medicine;Mentors;Metabolic syndrome;Minority Groups;Morbidity - disease rate;mortality;mortality risk;Nicotine;nicotine patch;nicotine replacement;non-smoker;Obesity;Outcome;Patient Recruitments;pharmacologic;physical inactivity;Population;premature;prevent;preventable death;Procedures;prospective;public health priorities;Race;Randomized;Recommendation;Reduce health disparities;Reporting;Research;Research Personnel;Research Project Grants;Risk;Sampling;satisfaction;Smoke;Smoker;Smoking;Smoking and Health Research;smoking cessation;success;Tissues;Tobacco;tobacco exposure;Tobacco Industry;tobacco products;Tobacco use;Unhealthy Diet;Weight;Weight Gain

PROJECT_TITLE: A Comparison of Electronic Cigarettes and Combination Nicotine Replacement Therapy among Individuals with Obesity who Smoke


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cannabinoid Research;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Substance Misuse;Women's Health Research

PI_NAMEs: GUNN, RACHEL LYN (contact)

PROJECT_TERMS: Acute;addiction;Address;African American;African American Women;Alcohol consumption;Alcohols;Anxiety;Anxiety Disorders;anxiety symptoms;behavior measurement;Behavioral;behavioral and social science;behavioral pharmacology;Biological Markers;biopsychosocial;Birth;Black race;black women;Cannabis;career;Centers of Research Excellence;child bearing;Chronic;Chronic Disease;Clinical;contextual factors;coping;Data;Depressive disorder;depressive symptoms;design;Development;Discrimination;Disease;disorder risk;distress tolerance;Dose;Ecological momentary assessment;effective intervention;Ensure;Equipment;Etiology;Event;experience;Feasibility Studies;Female;First Pregnancy Trimester;Frequencies;Goals;health disparity;Hispanic;Household;Hydrocortisone;improved;Income;Individual;Intervention;Investigation;Laboratories;Latinx;Lead;Leadership;Licensing;Link;marijuana use;marijuana use disorder;marijuana use in pregnancy;Maternal Health;maternal morbidity;Maternal Mortality;Mediating;Mental Depression;Mental Health;Mentorship;Methods;microaggression;Mission;Mood Disorders;mood symptom;Moods;multidisciplinary;negative affect;Negative Reinforcements;neonatal outcome;Not Hispanic or Latino;Outcome;Participant;participant enrollment;Pathological anxiety;Patient Self-Report;people of color;perceived discrimination;Perinatal;perinatal cannabis use;perinatal mental health;perinatal period;peripartum depression;Persons;Population;Postpartum Period;Pregnancy;pregnant;prenatal;Prevalence;Prevention;Process;professor;prospective;Psychological reinforcement;Psychologist;Public Health;Race;racial discrimination;racial disparity;racial diversity;recruit;Relapse;Reporting;Research;Research Design;Research Project Grants;Risk;Risk Factors;Sampling;skills;social determinants;social health determinants;Strategic Planning;Stress;stress management;stress reduction;substance use;Symptoms;Time;United States National Institutes of Health;Universities;Vulnerable Populations;White Women;Woman;Women's Health;Work

PROJECT_TITLE: Prospective Examination of the Impact of Cannabis Use and Social Determinants of Health on Maternal Mental Health


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Mental Health;Mental Illness;Pediatric;Prevention;Substance Misuse;Underage Drinking

PI_NAMEs: MICALIZZI, LAUREN GIOIA (contact)

PROJECT_TERMS: acceptability and feasibility;Acute;addiction;Age;Aggressive behavior;Alcohol consumption;alcohol use disorder;Alcohols;Ambulatory Care;antisocial behavior;Award;Behavior;Behavior Disorders;Behavioral;Biological Markers;Biosensor;Caregivers;Child;Child Behavior;Child Psychiatry;Child Rearing;Chronic;Chronic Disease;Clinical;Conduct Disorder;Conflict (Psychology);cost;Data;data access;Day Care;Decision Making;Development;developmental disease;diagnostic criteria;diaries;Discipline;Disease;disorder risk;Enrollment;Ensure;Equipment;Faculty;Family;follow-up;Funding;Goals;Hair;Hospitals;Hostility;Hour;Household;Hydrocortisone;improved;informant;innovation;Intake;intergenerational;Intervention;Intoxication;Investigation;Joints;Knowledge;Laboratories;Learning;life course persistent;Link;Longitudinal Studies;low socioeconomic status;Measurement;Measures;Mediating;Mediator;Mentors;Mentorship;Methods;Mission;multidisciplinary;novel;Oppositional Defiant Disorder;organizational structure;Outcome;Parent-Child Relations;parental influence;Parents;Participant;Patient Self-Report;Pattern;Peer Review;Persons;Population;Procedures;Process;professor;programs;prospective;Psychopathology;Puberty;Public Health;Randomized;recruit;Reporting;Research;Research Infrastructure;Research Project Grants;Resistance;Resources;retention rate;Risk;Risk Taking;Sampling;Sampling Studies;scale up;Schools;Scientist;sensor;sensor technology;Sleep;Stress;substance use;Substance Use Disorder;Symptoms;Teaching Hospitals;Testing;therapy development;Time;Universities;Wrist;Youth

PROJECT_TITLE: Impacts of Parental Alcohol Use and Stress on Youth Externalizing Psychopathology


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Women's Health Research

ORG_DEPT: CHEMISTRY

PHR: Alternating phosphorylation states of α− and β-tubulin in microtubules define a “toggle switch” model to be explored as a novel decision-point in cell behavior. Phosphorylation of α-tubulin or β-tubulin could determine whether a breast cancer cell metastasizes to a remote site or proliferates into a primary tumor, respectively. The α/β-tubulin toggle switch could have intrinsic biological significance as well as clinical value as a therapeutic target and prognostic indicator of metastatic potential.

PI_NAMEs: ROTENBERG, SUSAN A. (contact)

PROJECT_TERMS: 4T1;alpha Tubulin;Animal Model;behavior in vitro;beta Tubulin;Binding;Biological;Biological Markers;Breast;Breast Cancer Cell;cancer genome;CDC2 gene;cell behavior;Cell division;cell motility;Cell Proliferation;Cells;Cellular Structures;Chemotherapy-Oncologic Procedure;Clinical;Cytoskeleton;Databases;Enzymes;Event;experimental study;Fiber;Genomics;Growth;GTP Binding;Guanosine Triphosphate;Human;Hydrolysis;improved;in silico;In Vitro;in vivo;Malignant Breast Neoplasm;Malignant Neoplasms;MCF10A cells;MDA MB 231;Microtubules;migration;mimetics;Modeling;molecular dynamics;Motility;mouse model;Mus;mutant;Mutate;Mutation;mutation screening;N-Cadherin;Neoplasm Metastasis;novel;Phenotype;Phosphorylation;Phosphorylation Site;Primary Neoplasm;Process;prognostic indicator;Proliferating;Property;Protein Kinase C;Protein Kinase C Inhibitor;Signal Transduction;Site;small molecule inhibitor;Structure;Testing;therapeutic target;tumor

PROJECT_TITLE: Phosphorylation of α/β Tubulin is a 'Toggle Switch' in Human Breast Cancer


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Hypertension;Neurosciences

ORG_CITY: GLASSBORO

ORG_NAME: ROWAN UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Our 24-hour world requires people to work outside normal sleeping hours and is associated with the risk of developing health issues including hypertension; these hours induce a misalignment between the endogenous circadian system, also known as circadian misalignment. Despite these health issues related to a misalignment between the endogenous circadian system there are limited studies determining the mechanisms behind the development of these issues. Thus, the proposed studies will provide a major step in understanding the link between central mechanisms, cardiovascular regulation and associated cardiovascular risk in circadian misalignment.

PI_NAMEs: MARTINEZ, DIANA  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Address;Amino Acid Transporter;Animal Model;Astrocytes;Biological;Biological Process;Biomedical Research;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure regulation;Cardiovascular Diseases;cardiovascular health;Cardiovascular Pathology;cardiovascular risk factor;Cardiovascular system;circadian;Circadian desynchrony;circadian regulation;Data;Development;Disease;Early Diagnosis;Educational Grants;Equilibrium;Excitatory Amino Acids;extracellular;First Generation College Students;Funding;Glutamates;Goals;Health;heart rate variability;Hour;Hypertension;improved;Individual;integration site;Ischemic Stroke;Knowledge;Laboratories;Latinx;Link;Mission;Morphology;National Heart, Lung, and Blood Institute;neural circuit;Neurons;neuroregulation;Neurotransmitters;Nucleus solitarius;Pathway interactions;Pattern;Peripheral;Persons;Presynaptic Terminals;recruit;Reflex action;Regulation;Research;response;Risk;Rodent Model;Role;Rotation;Schedule;shift work;Sleep;Sleep Wake Cycle;Societies;Structure;student retention;student training;Synapses;Synaptic plasticity;Synaptic Transmission;System;Testing;Training;Underrepresented Populations;United States;United States National Institutes of Health;uptake;Work

PROJECT_TITLE: The Role of Astrocytes in Circadian Control of Blood Pressure in the Nucleus of the Solitary Tract


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Microbiome

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: PI: Baerga-Ortiz, Abel Title: Genotoxicity and immunogenicity of the uropathogenic specific protein (usp) in the gut Project Narrative Over the last decade, there has been an explosion of interest in the role of the gut microbiota in the maintenance of human health. While the gut microbiota is generally considered to be beneficial, certain microbial strains have been found, some widely distributed in the population, that harbor toxins and other negative effectors. This proposal aims to dissect the possible damaging effects to intestinal cells of the bacterial uropathogenic specific protein (USP), a toxin originally identified in urinary tract infections, but also found in the GI tract.

PI_NAMEs: BAERGA-ORTIZ, ABEL J (contact)

PROJECT_TERMS: Amino Acid Sequence;Anti-Bacterial Agents;Antibodies;Antibody Response;Architecture;Bacterial Toxins;bacteriocin;biobank;Biological Assay;C-terminal;Caribbean region;catalyst;Cell Death;cell injury;Cell Line;Cell Nucleus;Cells;Clathrin;Colon;colon carcinogenesis;Colorectal;colorectal cancer registry;Colorectal Neoplasms;Confocal Microscopy;Data;Databases;Development;Disease;disorder risk;DNA;DNA Damage;Endothelial Cells;Endothelium;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Escherichia coli;Escherichia coli Infections;experimental study;Explosion;Exposure to;familial colorectal cancer;Feces;Foundations;Functional disorder;Future;Gamma-H2AX;Gastrointestinal Diseases;gastrointestinal epithelium;Gastrointestinal tract structure;Gene Proteins;Genes;genotoxicity;Goals;gut bacteria;gut microbiota;Health;Hemolysin;Hospitals;Human;human tissue;immunogenic;immunogenicity;Immunoglobulin G;Immunoglobulin M;Incubated;Inflammatory Bowel Diseases;inhibitor;Institutional Review Boards;interest;Intestinal Diseases;Intestines;Japan;Label;Laboratories;Maintenance;Mediating;Metagenomics;microbial;Monitor;mutant;Neoplasms;novel;nuclease;Onset of illness;Organoids;pathogenic bacteria;Pathogenicity;Patients;Persons;Phosphorylation;Physiological;Physiology;Plasma;Pontine structure;Population;Proteins;Puerto Rico;receptor;Recombinants;Reporting;Research Personnel;response;Risk Assessment;Risk Factors;Role;Sampling;Serology test;stool sample;Students;Tertiary Protein Structure;Testing;Tissue Engineering;Tissues;Toxic effect;Toxin;Umbilical cord structure;Urinary tract;Urinary tract infection;Veins;Western Blotting;Woman;Work

PROJECT_TITLE: Genotoxicity and immunogenicity of the uropathogenic specific protein (USP) in the gut

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-A (SU)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: COLUMBIA

ORG_DEPT: BIOLOGY

ORG_NAME: BENEDICT COLLEGE

ORG_STATE: SC

PHR: While JQ1 as an inhibitor of epigenetics showed very promising results in treatment of cancer including triple negative breast cancer (TNBC), it developed resistance in TNBC. We propose to test a hypothesis that downregulation of a protein in cell fusion named MFSD2 mediates JQ1-induced cell fusion and drug resistance. Successful completion of the project will lead to future identification of specific MFSD2 activators as drug candidates to prevent JQ1 resistance in TNBC.

PI_NAMEs: AI, WALDEN  (contact)

PROJECT_TERMS: ABCG2 gene;Acetylation;anti-cancer research;Antibodies;Apoptotic;Binding;Bioinformatics;Breast Cancer Cell;Bromodomain;cancer cell;cancer stem cell;cancer therapy;CD14 gene;CD44 gene;Cell Extracts;Cell fusion;Cell Separation;Cells;Chemoresistance;chemotherapy;ChIP-seq;Chromatin;Clinical;Coculture Techniques;college;CRISPR/Cas technology;design;Disease;Down-Regulation;drug candidate;Drug resistance;Epigenetic Process;experience;Fluorescence;Future;Gene Expression;Generations;Growth;Heterogeneity;Histones;Human;Hybrid Cells;Immune;Immunocompromised Host;In Vitro;in vivo;inhibitor;Knock-out;Large-Scale Sequencing;lentivirally transduced;Lysine;Malignant Breast Neoplasm;Mammary Neoplasms;Mammospheres;MDA MB 231;Mediating;Mediator;Modality;Modeling;Molecular Biology;monocyte;Mus;mutant;Names;Nature;neoplastic cell;novel;novel strategies;Oncogenes;overexpression;Population;prevent;Process;programmed cell death ligand 1;Proteins;Qualifying;Reader;receptor expression;Resistance;Resistance development;response;RNA;stem cell biomarkers;syncytin;Tail;targeted treatment;Techniques;Testing;Therapeutic;Training;transcriptome sequencing;triple-negative invasive breast carcinoma;tumor;undergraduate student;Up-Regulation

PROJECT_TITLE: Targeting cell fusion as a novel strategy to tackle JQ1 resistance in triple negative breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-4 (SU)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: PROJECT NARRATIVE The PaRtnEring to build understanding oF gEnomics Responsibly Community Health Worker (PREFER CHW) genomics research education program is a first-of-its-kind training focused on building CHW competencies in genomics to support a diverse genomics research workforce and enhance diversity of participants in genomics research. In partnership with five sites in the Southeast United States we will develop, deliver, and evaluate PREFER CHW. At the conclusion of the program, we will have trained a cohort of 150 CHWs across four states and equipped partner site faculty to continue delivering PREFER CHW in the future.

PI_NAMEs: ALLEN, CAITLIN GLOECKNER (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Address;Adoption;Centers for Disease Control and Prevention (U.S.);cohort;Collaborations;Communities;community building;Community Health Aides;Community Health Networks;Community Workers;Competence;Consensus;design;Disadvantaged;Diverse Workforce;Education;education research;Educational Curriculum;Educational process of instructing;Educational workshop;Effectiveness;Ensure;Evaluation;Faculty;Feedback;Future;genome integrity;Genomic medicine;Genomics;Goals;Growth;Health;health care delivery;health management;High Prevalence;Home;implementation framework;Improve Access;improved;Individual;interest;Intervention;Interview;Knowledge;Lead;Learning;learning materials;Learning Skill;Low Income Population;Maintenance;Medical;member;Methods;Mississippi;Modeling;National Human Genome Research Institute;Neighborhood Health Center;North Carolina;Participant;participant retention;Patient Recruitments;Population Heterogeneity;Preparation;Process;Program Sustainability;programs;Race;racial minority population;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;Research;Research Support;Resources;Role;Rural;service delivery;Site;Social Network;South Carolina;Strategic vision;Surveys;Tennessee;Training;trend;United States;United States National Institutes of Health;Universities;Update;Work

PROJECT_TITLE: PaRtnEring to build understanding oF gEnomics Responsibly: the PREFER Community Health Worker Genomics Research Education Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-M (J2)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: This project will support the use of Tetrahymena thermophila as a tool for basic and applied biomedical research. Research conducted with this organism has contributed fundamental knowledge of key biological processes and revealed understanding of health-related phenomena including cancer, aging, (in)fertility, respiratory and neuroendocrine function. It has also proven useful for practical applications as manufacturing system for vaccine candidates and therapeutics proteins for the treatment of human disease.

PI_NAMEs: CHALKER, DOUGLAS LEE (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Aging;analysis pipeline;applied biomedical research;Applied Research;base;Bioinformatics;bioinformatics resource;Biological Phenomena;Biological Process;Biology;Biomedical Research;Catalogs;Cellular biology;Collection;Communities;cost;Data;data curation;Data Set;Disease;DNA sequencing;Educational process of instructing;Engineering;Ensure;epigenome;Exhibits;Fertility;Funding;Future;Gene Expression;Generations;Genes;Genetic;Genome;genome database;genome resource;genomic data;Genomics;Goals;Growth;Health;Human;human disease;improved;Infertility;Informatics;innovation;interest;interoperability;Investigation;Ion Channel;knockout gene;Knowledge;Laboratories;Lesion;Link;Maintenance;Malignant Neoplasms;manufacturing systems;Mission;Molecular Biology;mutant;Mutate;Neurosecretory Systems;novel;Nuclear;Online Systems;Ontology;operation;Organism;Outcome;Phenotype;Plasmids;practical application;Practice Management;preservation;Production;Proteins;Publications;Recombinant Proteins;repository;Research;Research Personnel;Research Support;Resources;respiratory;science teacher;Scientist;Secure;Services;Speed;Study models;System;Tetrahymena;Tetrahymena thermophila;therapeutic protein;tool;undergraduate student;Universities;Update;user-friendly;Vaccine Antigen;vaccine candidate;Visualization software;Washington;Water;web portal;web site;wiki;Work

PROJECT_TITLE: A Resource Center for Tetrahymena Thermophila

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-J (55)]


NIH_SPENDING_CATS: Genetics;Human Genome


PROJECT_TERMS: Advisory Committees;analysis pipeline;Bioinformatics;biological research;Biomedical Research;Cell Line;Communities;Data;Data Files;Data Set;DNA Sequence;epigenome;Evaluation;Funding;Gene Expression;Genes;genome browser;genome database;genome resource;genomic data;Goals;Guidelines;human disease;improved;Informatics;innovation;interoperability;Investigation;Link;Maintenance;Monitor;Ontology;operation;plasmid DNA;Process;Proteins;Research;Research Personnel;Resources;Sampling;Tetrahymena;Tetrahymena thermophila;Update;usability;web portal;web site;Work


NIH_SPENDING_CATS: Data Science;Genetics;Human Genome

PROJECT_TERMS: Acceleration;Applied Research;Basic Science;Biological;Cellular biology;Communication;Communities;Country;Custom;Data;Data Science;Data Set;data visualization;Databases;Deposition;design;Disease;DNA sequencing;Engineering;Ensure;epigenome;experience;Funding;Future;Gene Expression;Gene Mutation;Genes;Genetic;Genetic study;Genome;genome browser;genome database;genome resource;genomic data;Goals;Growth;Health;Human;improved;Information Centers;knockout gene;Laboratories;Life Cycle Stages;Link;member;Molecular Biology;mutant;Mutate;next generation;Nuclear;Organism;Outcome;Phenotype;plasmid DNA;Price;Research;Research Personnel;Resources;Scientist;Services;Source;Standardization;student participation;Study models;Technology;Tetrahymena;Tetrahymena thermophila;Time;tool;Training;transcriptome sequencing;Translational Research;undergraduate student;Universities;user-friendly;Visualization;Water;wiki


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative New computational tools will be developed to analyze biomolecular conformational ensembles and discover the underlying functional mechanisms. The tools will complement experiments in understanding biomolecular function at the atomic level. The results produced by the tools will be leveraged for drug discovery and biomolecular design.

PI_NAMEs: HAMELBERG, DONALD  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Algorithms;Biochemistry;Biological;biological systems;Biophysics;Collaborations;Communities;Complement;complex data;computerized tools;Coupled;Data;data to knowledge;Dedications;design;drug discovery;Experimental Designs;experimental study;Free Energy;innovation;Knowledge;laboratory experiment;Methods;Mission;Molecular;Molecular Conformation;molecular dynamics;Pharmacologic Substance;Physiological Processes;rapid growth;Sampling;simulation;System;Testing;tool;Use Effectiveness;Work

PROJECT_TITLE: Developing computational tools to complement experiments in understanding biomolecular function from conformational ensembles

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dental, Oral, and Craniofacial Disease

ORG_CITY: CHENEY

ORG_NAME: EASTERN WASHINGTON UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative  This project seeks to expand understanding of how decoration of Notch signaling receptors with sugars influences the formation and function of osteoclasts, bone-dissolving cells. Completion of this work will contribute to knowledge of Notch signaling regulatory mechanisms. In the longer term, better understanding of this phenomenon may lead to new therapies based on finer control of these cells to prevent bone loss.

PI_NAMEs: ASHLEY, JASON WAID (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Architecture;Autoimmune Diseases;bone;Bone Density;bone loss;Bone Matrix;bone preservation;Bone remodeling;Bone Resorption;Cataloging;Cells;Chemosensitization;combinatorial;Development;Disease;EGF gene;Enzymes;Estradiol;Exhibits;experience;experimental study;Extracellular Domain;Failure;Family;Fracture;fringe protein;Fucose;Fucosyltransferase 1;Future;Gene Expression;Genetic Transcription;Giant Cells;glycosylation;glycosyltransferase;Goals;healing;High-Throughput RNA Sequencing;improved;Individual;Infection;Inflammation;Inflammatory;knock-down;Knowledge;life span;Ligands;Measurement;Mediating;member;Metastatic Neoplasm to the Bone;Methods;MFNG gene;Microscopic;mineralization;Modeling;Morphology;mouse model;Mus;next generation;notch protein;Notch Signaling Pathway;novel strategies;novel therapeutics;osteoclastogenesis;Osteoclasts;Osteolysis;overexpression;Pathway interactions;Pattern;Physiology;Positioning Attribute;Postmenopause;prevent;Process;Proteins;receptor;Receptor Activation;Receptor Signaling;recruit;Regulation;repaired;Resistance;response;Retroviridae;Risk;Role;Signal Pathway;Signal Transduction;skeletal;sugar;System;Testing;Therapeutic;therapeutic candidate;therapeutic target;Transferase;Work

PROJECT_TITLE: Fringe regulation of Notch signaling in osteoclasts


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: EDINBURG

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

ORG_STATE: TX

PHR: This study utilizes innovative genomics techniques to address critical barriers to understanding FOXO transcription factor-driven developmental and cellular processes that promote stem cell fate specification and function in the contexts of glioblastoma multiforme (GBM) and myoblasts. Single cell RNA Seq will be used to determine whether FOXO transcription factors drive the fundamental developmental NOTCH Pathway within the context of stem cells and/or in neighboring differentiated cells. This study will also investigate the differential impacts of FOXO factors on the JAK/STAT Pathway in stem cell settings. 1 Updated May 2018

PI_NAMEs: KENIRY, MEGAN E (contact)

PROJECT_TERMS: Address;ATAC-seq;Automobile Driving;Binding;Biological Process;Blood;Cancer Prognosis;Cell Differentiation process;cell fate specification;Cell Lineage;Cell Maintenance;Cell Physiology;Cells;Chimera organism;CRISPR/Cas technology;Cytoplasm;Data;Development;Developmental Process;differential expression;Disease;DNA;Embryo;embryonic stem cell;Environment;ES01;experimental study;FOXO1A gene;FOXO3A gene;Gene Expression;Gene set enrichment analysis;Genes;Genetic Models;Genetic Transcription;genome editing;Genomics;Glioblastoma;Goals;Hand;Hematopoietic;Hispanic-serving Institution;IGF1 gene;innovation;insight;Intestines;Janus kinase;loss of function;Malignant Neoplasms;Maps;Mesenchymal;migration;MLLT7 gene;Mus;Muscle;mutant;Myoblasts;neural;Neurons;NOTCH1 gene;NOTCH3 gene;novel;Nuclear;Output;Pathway interactions;PIK3CG gene;Platelet-Derived Growth Factor;Proteins;Publishing;Receptor Activation;Regulation;Research;Research Personnel;RNA Interference;Role;Sampling;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;STAT3 gene;stem;stem cell biology;stem cell fate;stem cell fate specification;stem cell genes;stem cells;stemness;Students;success;Techniques;transcription factor;transcriptome sequencing;United States;Update;Work

PROJECT_TITLE: Investigating fundamental signal transduction mechanisms impacted by FOXO transcription factors on NOTCH and JAK/STAT Pathways in stem cell contexts


ORG_CITY: BERKELEY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARATIVE The development of single-cell genomics technologies has been a driving force in biomedical research over the past decade because of the throughput, sensitivity, and precision with which such techniques can dissect complex biological systems. The goal of this research program is to develop new hardware and software tools for multimodal precision measurements of single cells and tissues to drive the next generation of data-driven systems biology research.

PI_NAMEs: STREETS, AARON  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Atlases;Bar Codes;Biomedical Research;Cataloging;Cell Physiology;Cells;Cellular Morphology;Chemicals;complex biological systems;Data;Development;Disease;DNA;DNA sequencing;DNA-Protein Interaction;driving force;Epigenetic Process;epigenome;Goals;histone modification;Human;In Situ;insight;Measurement;Measures;Methylation;microfluidic technology;Microfluidics;Microscopy;Molecular;Molecular Biology;multimodality;next generation;novel;optical imaging;Optics;Organ;Phenotype;Positioning Attribute;programs;protein distribution;Proteome;Proteomics;Proxy;Research;sequencing platform;single cell genomics;single-cell RNA sequencing;Software Tools;Spatial Distribution;Systems Biology;Techniques;Technology;technology development;Tissues;tool;transcriptome;Translations;Whole Organism

PROJECT_TITLE: Microfluidic, molecular, and optical tools for multimodal measurement of single cells and tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-H (56)]