NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Genetics;Human Genome;Neurosciences;Substance Misuse

PROJECT_TERMS: Address;Administrative Coordination;Advisory Committees;Alcohol consumption;alcohol research;alcohol response;Alcohols;Animals;Area;behavioral genomics;Bioinformatics;Biometry;Budgets;Collaborations;Committee Members;Community Health Education;Data;data sharing;Development;drinking behavior;Education;Educational Activities;Environment;Event;Extracellular Matrix;Familiarity;Feedback;Future;Genomics;Goals;graduate student;Grant;Human Resources;Information Dissemination;Medical Education;meetings;National Institute of Drug Abuse;National Institute on Alcohol Abuse and Alcoholism;neuroadaptation;outreach;Play;Productivity;programs;Quality Control;Recording of previous events;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Rest;Risk;Role;Science;Services;Structure;Synapses;synergism;Training;Training and Education;Work;Writing

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Chicago

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative The proposed research is relevant to public health because it will optimize a powerful set of genetic tools to monitor with high spatiotemporal resolution the biochemistry linked to neuronal plasticity in the brain. This will enable new studies into basic mechanisms in learning and memory, sensory adaption and investigations into disease-related questions involving recovery from injury, addiction and chronic pain.

PI_NAMEs: DOMBECK, DANIEL A (contact);GRIESBECK, OLIVER ;YASUDA, RYOHEI

PROGRAM_OFFICER_NAME: PUCAK, MICHELE LYNN

PROJECT_TERMS: addiction;Animal Model;awake;base;Behavior;Benchmarking;Biochemical;Biochemistry;biophysical analysis;Biosensor;Brain;Brain imaging;Calcium;calmodulin-dependent protein kinase II;Cell Nucleus;Cell Separation;chronic pain;CREB1 gene;dark rearing;Dendrites;Development;Disease;Electric Stimulation;Environment;Event;experience;experimental study;Feedback;fluorescence imaging;Fluorescence Resonance Energy Transfer;fluorophore;Generations;Genetic;Glutamates;Goals;hemodynamics;hippocampal pyramidal neuron;Hippocampus;Hour;Image;improved;in vivo;Individual;injury recovery;Investigation;Ion Channel;Label;Learning;Libraries;light scattering;Link;Mammalian Cell;Measurement;Measures;Mediating;Memory;Methods;millisecond;Molecular;Monitor;Morphogenesis;Morphologic artifacts;Movement;multiplexed imaging;Mus;Natural regeneration;neural circuit;Neurites;neuronal circuitry;Neuronal Plasticity;Neurons;Noise;novel;novel strategies;operation;Organism;Pathway interactions;Pattern;Performance;Photic Stimulation;place fields;Population;Process;Property;Proteins;prototype;Public Health;receptor;recruit;redshift;Regulation;Reporter;Research;Resolution;response;screening;sensor;Sensory;Signal Pathway;Signal Transduction;Slice;Spatial Behavior;spatiotemporal;Structure;Synapses;Synaptic plasticity;Time;tool;two photon microscopy;two-photon;Validation;Vertebral column;Visual Cortex;way finding

PROJECT_TITLE: Multiplex Imaging of Brain Activity and Plasticity with Optimized FRET/FLIM-based Sensors


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PI_NAMEs: PHILLIPS, TAMARA J. (contact)

PROJECT_TERMS: addiction;Address;Adenylate Cyclase;Affect;Alcohol consumption;alcohol research;alcohol risk;Alcohols;Amygdaloid structure;Animals;antagonist;Astrocytes;Avidity;Behavior;Behavioral;behavioral genomics;Brain;Brain region;Breeding;Cell Nucleus;cell type;Cells;Chronic;chronic alcohol ingestion;Cilia;Clinical;Cognitive;cognitive performance;cognitive testing;Consumption;Data;DNA;DNA analysis;DNA Methylation;efficacy evaluation;Epigenetic Process;Ethanol;Extracellular Matrix;Family;flexibility;Funding;Gene Expression;gene network;Genes;Genetic;Genetic study;Genetic Transcription;Genetic Variation;Goals;Grant;Individual;Individual Differences;individual variation;instrument;Intake;interest;Lead;Length;Macaca;Macaca mulatta;Measures;member;Monkeys;mouse genetics;Mus;neuroadaptation;Neurons;Nucleus Accumbens;Pathway interactions;Performance;Phenotype;Population;preference;Proteins;Protocols documentation;public database;Publishing;Rattus;receptor;Recording of previous events;Research;Residual state;response;Retirement;Rewards;Risk;Role;serotonin receptor;sex;Signaling Molecule;single-cell RNA sequencing;somatostatin receptor 3;Synapses;Tail;Taste Perception;Techniques;Testing;Tissue Sample;Tissues;transcriptome;transcriptome sequencing;Untranslated RNA;Variant;Water

PROJECT_TITLE: Mouse genetics: risk and individual variation


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative This project will generate a harmonized national database of historical redlining, historic and current environmental hazards, housing investment, gentrification, and longitudinal neighborhood demographics and socioeconomics, and examine structural racism as it is embedded in neighborhoods with 1) the resulting inequalities in neighborhood `access and exposure' that drive health opportunities, and 2) disparities in morbidity and mortality risk beginning in mid-life in a nationally representative longitudinal study, the Health and Retirement Study.

PI_NAMEs: MEIER, HELEN CARMON SPINK (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Address;Aging;Air Pollution;Alcohols;American;Area;Behavioral;Cardiovascular Diseases;Censuses;Centers for Disease Control and Prevention (U.S.);Chronic Disease;Cities;Data;Data Set;Data Sources;Databases;demographics;density;Diabetes Mellitus;Disclosure;disparities in morbidity;Economics;Environment;Environmental Hazards;Exposure to;Federal Government;Fire - disasters;Fostering;Geography;Goals;Government;Green space;Grouping;Health;Health and Retirement Study;health care availability;health care service;health disparity;health inequalities;Health Promotion;Healthcare;High Prevalence;high risk;Home;Housing;Hypertension;Individual;Industrialization;Inequality;Institution;Institutional Racism;Insurance;Investments;Knowledge;Life Expectancy;Location;Longitudinal Studies;Maps;Measures;Mediating;Mental Health;metropolitan;middle age;Minority;Morbidity - disease rate;mortality;mortality risk;multiple chronic conditions;Neighborhoods;Outcome;Ownership;Participant;physical conditioning;Policies;Population;Population Dynamics;Poverty;Prevalence;Production;Race;Research;residential segregation;Resources;Risk;Security;Shapes;social;Societal Factors;socioeconomics;Source;Strategic Planning;Structural Racism;Structure;Supermarket;Time;tobacco products;Toxin;United States Environmental Protection Agency;United States National Institutes of Health;Work

PROJECT_TITLE: The impact of redlining and place-based systemic racism on health inequalities at mid-life


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Esophageal Cancer;Genetic Testing;Genetics;Human Genome;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE While millions of Americans harbor the pre-cancerous lesion, Barrett’s esophagus, putting them at elevated risk of esophageal cancer, many will not develop cancer and this progression is poorly understood. This proposed research will determine important contributors to progression and identify how they can be used to predict progression risk.

PI_NAMEs: STACHLER, MATTHEW D (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: advanced disease;American;Aneuploidy;Area;Barrett Esophagus;Benign;Bile Reflux;Biological Assay;Biological Markers;biomarker identification;biomarker panel;Biometry;Biopsy;cancer genomics;Case/Control Studies;Chronic;Clinical;clinical implementation;Clinical Management;clinically relevant;clinically significant;cohort;Collaborations;Collection;Computational Biology;Computational Technique;cost;cost effective;Coupled;Credentialing;Detection;Development;Devices;Diagnosis;Disease;disorder risk;DNA Sequence Alteration;Dysplasia;Early Diagnosis;Endoscopic Biopsy;Endoscopy;epigenomics;Epithelium;Esophageal Adenocarcinoma;Esophageal Tissue;Esophagus;Evaluation;Functional disorder;Funding;Gastroenterologist;Gastroenterology;Gastroesophageal reflux disease;Genome;genomic biomarker;Genomics;Goals;Head;High Prevalence;high risk;Histologic;improved;Incidence;innovation;Institution;Intestines;Left;Lesion;Malignant neoplasm of esophagus;Malignant Neoplasms;Methylation;methylation biomarker;Modeling;Mutation;Mutation Detection;novel;novel therapeutics;Outcome;Pathology;patient population;patient stratification;Patients;Persons;Ploidies;Positioning Attribute;Precancerous Conditions;predictive marker;premalignant;prevent;Procedures;Process;progression risk;Prospective cohort;Publishing;Recommendation;Reporting;Research;Resources;response;Risk;risk stratification;Sampling;screening;Side;Stratification;Structure;subclonal heterogeneity;surveillance strategy;Talents;targeted sequencing;Testing;Time;Tissue Banks;Tissue Sample;Tissues;tool;TP53 gene;Validation

PROJECT_TITLE: Optimization and validation of a biomarker panel for risk stratification in Barrett's esophagus

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: NZUMBE EPIGENETICS

PHR: Project Narrative Improving environmental health literacy (EHL) will help people make more informed choices resulting in better public health. Nzumbe has assembled an outstanding team of environmental scientists, media developers and educators to develop innovative, experiential undergraduate EHL educational tools based on epigenetic science.

PI_NAMEs: ROUNTREE, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Active Learning;Affect;Air;American;Architecture;Award;Basic Science;Behavior;Biological Models;Biology;Brain;Breathing;Businesses;Chemicals;Collaborations;college;Communities;Computer software;Consumption;cost;Custom;Decision Making;Development;Disease;Disease susceptibility;Eating;Education;education cost;Educational process of instructing;Endowment;Environment;Environmental Exposure;Environmental Health;Epigenetic Process;epigenetic regulation;epigenome;Equipment;experience;experimental study;falls;fetal;fictional works;Financial Support;Folic Acid;fungus;Gene Expression Regulation;Genes;genetic makeup;Goals;Grant;grasp;Growth;Habits;hands-on learning;Health;health disparity;health literacy;Health Professional;high school;Home;Human;Human Development;human disease;improved;in silico;innovation;Institution;junior high school;Knowledge;Laboratories;Language;Learning;Learning Module;learning outcome;Life Style;Link;man;Marketing;Measures;member;model organism;National Institute of Environmental Health Sciences;Neurospora;Neurospora crassa;novel;offspring;online delivery;Oregon;Organism;Outcome;Persons;Phase;Phenotype;Play;Policy Maker;Pollution;Population;Pregnancy;Process;Public Health;Reporting;response;Risk;risk mitigation;Role;Safety;Schools;Science;Scientist;Shapes;Small Business Innovation Research Grant;Social Interaction;Statutes and Laws;Stress;Structure;Students;success;Testing;Time;tool;Translations;undergraduate student;Universities;Vertebral column;Visual;Visualization;web based software;Work

PROJECT_TITLE: Using epigenetic science to improve environmental health literacy


NIH_SPENDING_CATS: Genetics;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: Many brain disorders are associated with circadian and myelin phenotypes, but how these two biological processes intersect during brain maturation remains unknown. The proposed experiments aim to deepen our understanding of the circadian mechanisms mediating myelin-forming cell dynamics and myelination in neurodevelopment and early adulthood. Through the development of new model systems allowing us to probe the interaction of both environmental and molecular circadian disruption and developmental and adaptive myelination, we will contribute a more comprehensive understanding of myelin biology, ultimately providing novel chronotherapeutic strategies targeting the dysmyelination associated with numerous brain disorders.

PI_NAMEs: VALDEZ, ERIN G (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Adult;Alzheimer's Disease;ARNTL gene;Attention;Attention deficit hyperactivity disorder;Automobile Driving;Axon;Behavior;Behavioral;Biological;Biological Models;Biological Process;Biology;Brain;Brain Diseases;brain health;Brain Pathology;Cell Density;Cell Differentiation process;Cell Lineage;Cell Maintenance;Cell Proliferation;Cells;Chronic;circadian;Circadian desynchrony;Circadian Dysregulation;circadian pacemaker;Complex;Data;density;Development;Discipline of Nursing;Disease;dysmyelination;Embryo;Embryonic Development;emerging adult;Encapsulated;experimental study;fetal;Foundations;Functional disorder;Genes;Genetic;Genetic Polymorphism;Histology;Hour;in vivo;individuals with autism spectrum disorder;insight;Jet Lag Syndrome;knock-down;Knock-out;Knockout Mice;Learning;Life;Link;Maintenance;Mediating;Memory;Metabolic;Microscopy;Mitotic;Modeling;Molecular;Morphology;Motor;mouse model;Multiple Sclerosis;Mus;Myelin;myelination;Nerve Degeneration;nerve stem cell;Nervous System Disorder;Nervous System Physiology;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neurons;novel;offspring;oligodendrocyte progenitor;Oligodendroglia;optogenetics;Periodicity;Phase;Phenotype;Physiological;postnatal;postnatal development;Pre-Clinical Model;precursor cell;Pregnancy;pregnant;prenatal;Process;Proliferating;Publishing;Research;Resolution;Resting Phase;Role;Running;Signal Pathway;Signal Transduction;Social Behavior;stem cell population;Structure;System;Therapeutic;Time;transcriptome sequencing;transduction efficiency;Variant;white matter;Work;young adult

PROJECT_TITLE: Circadian mechanisms of myelination

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Precision Medicine;Regenerative Medicine

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Narrative Microphysiological tumor systems, which are small human tumors grown outside the body, are useful models for cancer research, drug discovery, and personalized therapy, but they lack clinically relevant imaging endpoints. This project will develop a quantitative and high-resolution approach to image these microtumors using the existing array of clinical PET radiotracers, thus bridging the gap in physical scale that exist between clinical tumor imaging and microphysiological tumor models. The approach will be demonstrated in a pilot study in a cohort of head-and-neck cancer patients.

PI_NAMEs: PRATX, GUILLEM  (contact);SUNWOO, JOHN B;YANG, YUNZHI

PROGRAM_OFFICER_NAME: RIZWAN, ASIF M

PROJECT_TERMS: 3-Dimensional;Address;Animal Cancer Model;Animal Model;anti-cancer research;Biocompatible Materials;Biological;Biological Assay;Biological Markers;Biological Process;Biological Testing;biomedical imaging;Blood Vessels;Cancer Diagnostics;cancer imaging;Cancer Model;Cancer Patient;Capillary Permeability;Cell Culture Techniques;Cell Proliferation;Cells;Characteristics;chemotherapy;Clinical;clinical imaging;Clinical Research;clinical translation;clinical trial on a chip;Clinical Trials;clinically relevant;cohort;Complement;cost;Data;Dedications;Development;Device Designs;Diagnostic;Diagnostic Imaging;Discipline of Nuclear Medicine;drug discovery;Endothelial Cells;Engineering;Environment;experience;Extracellular Matrix;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Foundations;Future;Goals;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;Human;Hypoxia;Image;image translation;imaging approach;Imaging Device;imaging modality;In Vitro;in vivo;individual patient;instrument;interest;Laboratories;Measures;Metabolic;Metabolism;meter;Microfabrication;Microfluidic Microchips;Microfluidics;microPET;Microscopy;Modeling;Molecular;Mus;neovasculature;novel therapeutics;Oncology;Optics;Organoids;Patient imaging;patient response;Patients;Perfusion;perfusion imaging;personalized medicine;Pharmacologic Substance;Physiological;Physiology;Pilot Projects;Positron;Positron-Emission Tomography;pre-clinical;pre-clinical research;preclinical study;preclinical trial;predictive test;Procedures;Process;Property;prospective;quantitative imaging;Radiation therapy;Radioisotopes;Radionuclide Imaging;Radiopharmaceuticals;radiotracer;Reproducibility;Research;Research Personnel;Resolution;response;routine imaging;Running;Sampling;Science;Solid Neoplasm;standard of care;stem cells;System;Therapeutic;Tissue Engineering;Tissues;Tracer;trafficking;Translating;translational study;Treatment Protocols;treatment response;tumor;tumor microenvironment;Tumor Tissue;tumor xenograft;uptake;Validation;vascular tissue engineering;Vascularization;Visualization;With laterality;Work;X-Ray Computed Tomography;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Preclinical microphysiological tumor models for nuclear medicine

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

PI_NAMEs: GUIZZETTI, MARINA  (contact)

PROJECT_TERMS: Accounting;addiction;Adult;Affinity Chromatography;alcohol availability;Alcohol consumption;alcohol effect;Alcohols;Astrocytes;behavioral genomics;Binding;Brain;brain cell;brain parenchyma;Brain region;CCL18 gene;Cell Adhesion Molecules;cell type;Cells;cellular targeting;Chondroitin Sulfate A;Chondroitin Sulfates;Control Animal;Core Protein;differential expression;Disaccharides;Discrimination;drinking;Ethanol;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Extracellular Space;Funding;Genes;Genetic;genome-wide analysis;Glycosaminoglycans;glycosylation;Goals;Harvest;Heparitin Sulfate;Hyaluronic Acid;in vivo;inhibitor;interstitial;Intervention;Linear Models;liquid chromatography mass spectrometry;Medial;Messenger RNA;Methods;Molecular;Molecular Target;Mus;neuroadaptation;Neuronal Plasticity;Nucleus Accumbens;Peptide Hydrolases;polysulfated glycosaminoglycan;preference;Prefrontal Cortex;Proteins;Proteoglycan;Protocols documentation;Research;Ribosomal Proteins;Ribosomes;Risk;RNA;Rodent;Role;sex;Signal Transduction;Structure;sugar;Sulfate;Techniques;Technology;Therapeutic Intervention;tool;transcriptome sequencing;Translating;Translations;translatome;Validation;Water

PROJECT_TITLE: Astrocytes, alcohol, and the extracellular matrix


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Human Genome;Neurosciences;Substance Misuse

PI_NAMEs: CUZON CARLSON, VERGINIA CARMELLA (contact)

PROJECT_TERMS: Age;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol response;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;American;Anatomy;annotation  system;Anterior;Antibodies;Astrocytes;Behavioral;behavioral genomics;Biological Assay;bisulfite sequencing;Brain region;brain tissue;Brodmann's area;Cause of Death;cell type;Cells;chronic alcohol ingestion;cingulate cortex;Consumption;Corpus striatum structure;Cytosine;Data;Data Set;design;Development;DNA Integration;DNA Methylation;DNA methylation profiling;Dorsal;Dose;drinking behavior;effective therapy;Electrophysiology (science);Elements;Engineering;Epigenetic Process;epigenome;epigenomics;Equilibrium;Ethanol;Extracellular Matrix;FDA approved;Female;Fluorescence-Activated Cell Sorting;Gene Expression;Gene Targeting;Genes;genetic manipulation;genome-wide;genome-wide analysis;Genomic Segment;Glutamates;Goals;Heavy Drinking;Individual;Link;Macaca;Macaca mulatta;male;Maps;Methylation;methylome;Modeling;Modification;Molecular;Monkeys;mouse genome;Mus;neural circuit;neuroadaptation;Neurons;neurotransmission;nonhuman primate;novel;Nucleic Acid Regulatory Sequences;Nucleus Accumbens;Pathway Analysis;Pharmaceutical Preparations;pharmacologic;Pharmacology;postsynaptic;preference;presynaptic;Primates;Process;Regulation;Regulator Genes;Relapse;Rodent;Role;Sampling;Self Administration;Signal Transduction;Slice;Specificity;Synapses;synaptic function;Technology;Testing;Tissues;tool;transcriptome sequencing;transcriptomics;translational approach;transmission process;Validation;Viral;Viral Vector;Work

PROJECT_TITLE: Translational examination of alcohol-associated epigenetic signatures: from primates to rodents


PI_NAMEs: GRANT, KATHLEEN A (contact)

PROJECT_TERMS: Alcohol consumption;alcohol effect;alcohol research;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Anatomy;ARHGEF5 gene;Behavior;Behavioral;behavioral genomics;Brain;Brain region;Catabolism;caudate nucleus;CD44 Antigens;Chronic;chronic alcohol ingestion;Cognition;Cognitive;cognitive performance;Corpus striatum structure;Data;Digestion;drinking;Electrophysiology (science);Equilibrium;Ethanol;Extracellular Matrix;Flavonoids;flexibility;Functional Magnetic Resonance Imaging;Funding;gamma-Aminobutyric Acid;Genes;genomic data;Glutamates;Glycosaminoglycans;Goals;Heavy Drinking;Histologic;Hyaluronic Acid;Hyaluronidase;Image;Impaired cognition;interstitial;Knowledge;Link;Long-Term Depression;Long-Term Potentiation;Macaca mulatta;Magnetic Resonance Imaging;Maps;Measures;Mediating;Metabolism;Modeling;Molecular;Monkeys;Motor;Mus;Nature;neural circuit;neuroadaptation;Neurons;novel;Nucleus Accumbens;Output;Performance;prevent;Process;Proteins;Publishing;putamen;receptor;regional difference;Research;Risk;Role;Sensory;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Techniques;transmission process

PROJECT_TITLE: Brain regional extracellular matrix molecules, corticostriatal circuitry function and alcohol drinking in monkeys and mice


PI_NAMEs: FORD, MATTHEW M (contact)

PROJECT_TERMS: Address;Alcohol consumption;alcohol exposure;alcohol response;Alcohols;Animal Model;Animals;Astrocytes;Attenuated;base;behavioral genomics;behavioral phenotyping;Bioinformatics;brain tissue;Breeding;Catabolism;CCL18 gene;Chromium;Chronic;chronic alcohol ingestion;Cognitive;cognitive process;cognitive testing;Collaborations;Controlled Environment;cost;Data;data integration;Databases;Dedications;DNA;DNA Methylation;Dose;drinking;Ethanol;Evaluation;Exhibits;experimental study;flexibility;Funding;Genetic;Genetic Variation;genome-wide;Genomics;Glycosaminoglycans;Grant;Head;High-Throughput Nucleotide Sequencing;Hyaluronan;Inbred Strain;Individual;Investigation;Libraries;Macaca;Macaca mulatta;Maintenance;Massive Parallel Sequencing;Methylation;Modeling;Modification;Motor Activity;mouse model;Mus;neuroadaptation;next generation sequencing;Performance;pharmacologic;Phenotype;Population Heterogeneity;preference;preservation;Procedures;Process;Protocols documentation;Reproducibility;Research;Research Personnel;Research Project Grants;research study;Resource Allocation;Resource Sharing;Resources;Ribosomal RNA;Risk;RNA;RNA analysis;RNA Processing;Role;Sampling;Scheme;Services;single cell analysis;Standardization;Synapses;System;Testing;Tissues;trait;transcriptome;transcriptome sequencing;Transgenic Mice;Translations;Validation;Water;Work

PROJECT_TITLE: Animal & Resource Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

PI_NAMEs: CONRAD, DONALD F. (contact)

PROJECT_TERMS: Alcohol abuse;alcohol exposure;alcohol research;alcohol risk;alcohol use disorder;Alcohols;analysis pipeline;ATAC-seq;Atlases;Automobile Driving;behavioral genomics;Big Data;Bioinformatics;Biological Markers;Biology;Biometry;Brain region;Categories;cell type;ChIP-seq;Computer Analysis;computer science;computing resources;Custom;Data;Data Analyses;data integration;data resource;Data Set;design;differential expression;DNA sequencing;Ensure;Epigenetic Process;experimental analysis;Experimental Designs;experimental study;Gene Expression;Genes;Genome;genomic biomarker;Genomics;high dimensionality;Human;Human Genetics;Individual;innovation;insight;Macaca;Maps;Methylation;Mus;neuroadaptation;Pathway Analysis;Pathway interactions;Pattern;Play;primary endpoint;Public Domains;Reporting;Reproducibility;Research Personnel;Research Project Grants;Resources;Role;Services;Signal Transduction;single-cell RNA sequencing;skills;statistics;success;Techniques;tool;transcriptome sequencing;web platform;Work;Writing

PROJECT_TITLE: Bioinformatics Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Genetics;Human Genome;Neurosciences;Pediatric;Substance Misuse

PI_NAMEs: RUTLEDGE-GORMAN, MARK T (contact)

PROJECT_TERMS: Adolescent;Affect;Age;Alcohol abuse;alcohol effect;alcohol research;alcohol response;Alcohols;ARHGEF5 gene;Athletic;Behavior;behavioral genomics;Biological;Biology;Brain;career;clinical practice;Communities;design;disadvantaged student;Disparity population;Doctor of Philosophy;doctoral student;Education and Outreach;Educational Curriculum;Evaluation;Female;General Population;Genetic;Goals;Health Occupations;Health Personnel;health science research;high school;High School Student;improved;Information Dissemination;Investigation;junior high school;K-12 Education;K-12 student;kindergarten;laboratory experience;Lead;Libraries;male;Medical;meetings;Minority Groups;Mission;National Institute on Alcohol Abuse and Alcoholism;neuroadaptation;Neurosciences;Neurosciences Research;next generation;novel;Outcome;peer;Performance;Policy Maker;Postdoctoral Fellow;Process;programs;Publications;Recovery;Research;Research Personnel;Resources;role model;Safety;school health;Schools;Scientist;Source;Sports;Students;symposium;teacher;Training;Translating;twelfth grade;undergraduate student;Underrepresented Minority;Underserved Population;Universities;Visit;vulnerable adolescent;web site;Work

PROJECT_TITLE: Information Dissemination Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE We propose to investigate the role of a nucleic acid-like protein modification, poly ADP-ribose (PAR) which can drive protein aggregation in stress granules and thereby contribute to age dependent neurodegenerative diseases. The knowledge gained from the proposed study will reveal the underlying mechanism by which PAR nucleates neurotoxic protein aggregation, which can lead to therapy development against the incurable ALS, FTLD, Alzheimer’s and Parkinson’s diseases.

PI_NAMEs: LEUNG, ANTHONY K L;MYONG, SUA  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: age related neurodegeneration;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Antineoplastic Agents;Automobile Driving;Biochemical;Biochemistry;Biophysics;Biotin;Cell model;Cells;Chemicals;Code;Color;Complex;Cytoplasmic Granules;Detection;empowerment;Exhibits;FDA approved;flexibility;fluidity;Fluorescence;Fluorescence Resonance Energy Transfer;Fluorescent Dyes;frontotemporal lobar dementia amyotrophic lateral sclerosis;fused in sarcoma;Knowledge;Label;Laboratories;Length;Link;Liquid substance;Measures;Mediating;Membrane;meter;Methods;Molecular;Molecular Analysis;Molecular Biology;molecular imaging;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neuropathology;neurotoxic;neurotoxicity;novel;Nucleic Acids;Parkinson Disease;Pathologic;Phase;Physical condensation;Poly Adenosine Diphosphate Ribose;Poly(ADP-ribose) Polymerase Inhibitor;Polymers;Positioning Attribute;Post-Translational Protein Processing;Preparation;Property;protein aggregation;Proteins;Proteome;Proteomics;recruit;Regulation;Ribonucleases;Ribonucleoproteins;RNA;RNA-Binding Proteins;Role;single molecule;single-molecule FRET;Solid;stress granule;Structure;Testing;therapy development;Universities;Variant;viscoelasticity

PROJECT_TITLE: Defining the Role of Poly ADP-ribose in Biomolecular Condensation in ALS and FTLD


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because determining how genetic regulation of microglia relates to neuroinflammatory changes seen in Alzheimer's disease is expected to inform future strategies to predict and prevent cognitive decline and progression to dementia. Thus, the proposed research is relevant to the NIA's mission that pertains to developing fundamental knowledge that will reduce the burden of Alzheimer's disease on society.

PI_NAMEs: DE JAGER, PHILIP L (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Acceleration;Adult;Affect;African American;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-Protein;Architecture;Automobile Driving;Autopsy;Binding;Biological;Biological Markers;Brain;brain cell;Brain Diseases;brain health;brain tissue;causal model;Cell Physiology;Cells;Chromosome 1;Chromosome Mapping;Clinical;Clinical Trials;Clinical Trials Design;clinically relevant;Cognitive;cohort;Data;Data Set;Dementia;Development;Disease;Disease susceptibility;drug development;Elements;Future;gene discovery;Gene Proteins;Generations;Genes;Genetic;genetic architecture;Genetic study;genetic variant;genome wide association study;genome-wide;genome-wide analysis;genomic locus;glial activation;Goals;Histologic;Human;Human Biology;human subject;Image;Immune;immune function;Immunotherapy;Impaired cognition;In Situ;In Vitro;in vivo;Individual;innovation;insight;Institution;Investigation;Joints;Knowledge;Ligands;Maps;Measures;Memory;Mendelian randomization;Mental disorders;Microglia;migration;mild cognitive impairment;Mission;Modeling;monocyte;Morphology;multimodality;Myelogenous;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;neuropsychiatric disorder;New York;novel;Onset of illness;Outcome Measure;Participant;Pathology;Phagocytosis;PLCG2 gene;Positron-Emission Tomography;Predisposition;prevent;prospective;Prospective cohort;protein expression;Proteins;Public Health;radioligand;Regulation;religious order study;Research;response;Role;Sampling;Senile Plaques;Societies;Structure;Susceptibility Gene;Synaptosomes;System;tau aggregation;tau Proteins;Testing;therapeutic target;Tissues;trait;transcriptome;Translating;Translations;TREM2 gene;TYROBP gene;Validation;Variant

PROJECT_TITLE: Discovery and validation of genetic variants affecting microglial activation in Alzheimer's disease

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: FARMINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE Many states are aggressively reforming their long-term services and supports systems by constraining the growth of nursing homes and expanding the availability of home and community-based services (HCBS), especially through the growth of Medicaid waiver programs, which intend to delay or avoid nursing home admission for individuals living at home and at risk for nursing home care. This study will determine how living with Alzheimer's disease and related dementia affects health service utilization, achievement of goals of care, and informal caregiver support systems, in a statewide, racially and ethnically diverse population of older adults enrolled in a Medicaid waiver program.

PI_NAMEs: FORTINSKY, RICHARD H (contact);ROBISON, JULIE THOMPSON

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Achievement;Acute;Address;Admission activity;adverse outcome;Affect;Agreement;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Assessment tool;Attenuated;Black race;Caring;Client;Cognitive deficits;Communities;community based service;Connecticut;Data;Dementia;dementia care;Elderly;Eligibility Determination;Emergency department visit;Enrollment;ethnic diversity;Ethnic Origin;Ethnic Population;experience;Funding;Goals;Growth;Health;health disparity;health service use;Health Services;Hispanic;Home;Home Nursing Care;Hospitalization;Impaired cognition;improved;Independent Living;Individual;informal caregiver;informal support;interest;Interview;Journals;Knowledge;Link;Medicaid;Medicaid services;Medicare/Medicaid;meetings;Nursing Homes;older adult;Older Population;Outcome;Participant;patient home care;Peer Review;person centered;Persons;Policies;Population;Population Heterogeneity;Population Programs;Population Study;Professional Organizations;programs;Publications;Race;racial diversity;racial population;Reporting;Retrospective cohort;Risk;Sampling;scientific organization;service programs;Services;Severities;success;Support System;waiver

PROJECT_TITLE: Impact of AD/ADRD on Health-Related Outcomes in a Statewide Population Enrolled in a Publicly-Funded HCBS Waiver Program for Older Adults


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Social Determinants of Health

PHR: Project Narrative The proposed research will provide critical information about home- and community-based services (HCBS) use, health outcomes, and health care costs for people with Alzheimer's disease and related dementias (ADRD). This knowledge will help inform state Medicaid policymakers who are seeking the most effective approach towards HCBS and ultimately improve health outcomes for people with ADRD.

PI_NAMEs: KIM, HYUNJEE  (contact)

PROJECT_TERMS: acute care;Affect;aging in place;Alaska;Alzheimer's disease related dementia;Bathing;care costs;Caring;Communities;community based service;comorbidity;cost;Cost Savings;design;District of Columbia;dual eligible;Elements;Eligibility Determination;Emergency department visit;Enrollment;ethnic minority;Exclusion;falls;Financial Support;Functional impairment;Goals;Health;Health Care Costs;Health Status;Home;Home Nursing Care;Hospitalization;Household;improved;Indiana;Information Systems;Insurance;Knowledge;Link;Low income;Marital Status;Maximum Likelihood Estimate;Medicaid;Medicaid services;Medical;Medicare;Medicare claim;Medicare/Medicaid;older adult;Outcome;Persons;Policies;Policy Maker;poor health outcome;Poverty;preference;Privatization;programs;Quality of life;racial minority;Research;Services;skills;social;sociodemographic factors;Sterile coverings;Time;Variant;Vulnerable Populations;Walking

PROJECT_TITLE: Home and Community-Based Service Use, Health Outcomes, and Health Care Costs for People with Alzheimer's Disease and Related Dementias


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BIRMINGHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The interdisciplinary Cell, Molecular, and Developmental Biology (CMDB) T32 training program is dedicated to training highly motivated students in cell, molecular and developmental mechanisms that contribute to normal and aberrant physiology, disease pathogenesis, and birth defects. The CMDB T32 program selects exceptionally talented predoctoral trainees that matriculate into the UAB Graduate Biomedical Sciences (GBS) umbrella program to provide them with enhanced training and career development opportunities, along with a flexible curriculum that can be tailored to the individual research and career goals of the trainee. Our overarching goal is offer a comprehensive and rigorous training program that nurtures the maturation of students into creative, independent-thinking, research scholars in the biomedical sciences.

PI_NAMEs: BELLIS, SUSAN L (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Cellular biology;Developmental Biology;Molecular Biology;Training Programs

PROJECT_TITLE: Training Program in Cell, Molecular, and Developmental Biology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative: Providing high quality home and community-based care (HCBS) for persons with Alzheimer's disease and related dementias is a national priority. Despite this priority, very little is known about the relationship between HCBS and person-reported outcomes (i.e., value of services from the client perspective) for those with and without AD/ADRD and whether person- reported HCBS outcomes influence health care use. Our proposed study will be the first to provide data on these complex relationships and will help inform the design of HCBS programs.

PI_NAMEs: JUTKOWITZ, ERIC ;SHIPPEE, TETYANA P. (contact)

PROJECT_TERMS: Accident and Emergency department;Address;Admission activity;Adult;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Behavior;care outcomes;care recipients;care systems;Caregiver support;caregiving;Caring;Client;Communities;community based care;community based service;Complex;Data;Dementia;dementia care;design;disability;Enrollment;experience;Family;Family Caregiver;Funding;Goals;Health;Health Care Rationing;health care service utilization;health plan;Healthcare;high risk;Home;Home Care Services;Hospitalization;improved;improved outcome;Infrastructure;innovation;Institution;Investments;Link;Long-Term Care;Measures;Medicaid;Medicaid eligibility;Medicare/Medicaid;Minnesota;nonalzheimer dementia;Nursing Homes;older adult;Older Population;Outcome;person centered;Personal Satisfaction;Persons;Play;Policies;programs;Quality of Care;Recommendation;Recording of previous events;Reporting;Research;Resources;Respondent;response;Role;Self Care;service programs;service providers;service utilization;Services;Surveys;trend;Variant

PROJECT_TITLE: Person-Reported and Health Care Utilization Outcomes of Home and Community Based Care Recipients With and Without Alzheimer's Disease and its Related Dementias


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: This proposal is for continued support for a highly successful Summer Research Program in human genomics for high school students, focusing on students from underrepresented and economically disadvantaged populations. During the eight-week program, students work side by side with NIH funded researchers on ongoing projects.

PI_NAMEs: VANCE, JEFFERY MARVIN (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Advertising;African American;Area;Asian;Awareness;Bioinformatics;Biological Sciences;career;Cities;college;College Preparation;Computational Science;Computers;Country;County;Creativeness;data management;design;disadvantaged student;Economically Deprived Population;Economics;Education;Ensure;Ethnic Origin;experience;Faculty;faculty mentor;field study;Florida;Foundations;Funding;Genetic;Goals;graduate student;Health;high school;High School Student;Hispanic;Home;Human;Human Genetics;human genomics;interest;Internet;Internships;Knowledge;Laboratories;Laboratory Technicians;Latino;Lead;matriculation;member;Memory;Mentors;Mission;National Institute of Neurological Disorders and Stroke;next generation;Not Hispanic or Latino;Participant;Population;Positioning Attribute;Postdoctoral Fellow;Privatization;programs;Race;recruit;Research;Research Personnel;research study;Rewards;Schools;Science;Side;skills;social;socioeconomics;Son;STEM field;Students;success;summer internship;summer research;Supervision;support network;Talents;Time;tool;Training;twelfth grade;Underrepresented Students;United States;United States National Institutes of Health;Universities;Vocational Guidance;Work

PROJECT_TITLE: Summer Research Experience in Biological and Computational Sciences


NIH_SPENDING_CATS: Cancer;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: ORLANDO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

PHR: Project Narrative Doxorubicin is a wonderful anti-cancer drug. Unfortunately, a major side effect of this drug is causing a muscle dysfunction in patients suffering from cancer in the U.S. and around the world. Doxorubicin induces inflammation by attracting M1 macrophages is now becoming a considerable cause of development and progression of muscular dysfunction and fatigue. We report as a preliminary data that presence of M1 macrophages causing immune mediated cell death called pyroptosis and adverse muscle remodeling. We have generated ES-Exosome from ES cells which could be an excellent therapeutic option as these cell free components don't form teratoma and are capable to attenuate pyroptosis and adverse muscle remodeling is proposed in the grant. Overall if successful, ES-Exos will provide protection in DOX induced muscle toxicity by inhibiting pyroptosis and adverse muscle remodeling at short and long term of the disease. Overall if successful ES-Exos could have broad therapeutic option treating in doxorubicin induced toxicity in related diseases as well as in various other muscle dysfunctions.

PI_NAMEs: KUKREJA, RAKESH C;SINGLA, DINENDER KUMAR (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Anti-Inflammatory Agents;anticancer activity;Antineoplastic Agents;Apoptosis;Attenuated;C57BL/6 Mouse;cancer cell;Cancer Patient;cancer therapy;CASP1 gene;Cell Death;Cell Death Induction;cell type;Cells;chemotherapeutic agent;chemotherapy;Clinic;clinical care;common symptom;cytokine;Data;Development;Disease;Doxorubicin;Drug Side Effects;embryonic stem cell;exosome;Fatigue;feasibility testing;Functional disorder;Grant;Human;IL18 gene;Immune;improved;In Vitro;in vivo;Infiltration;Inflammasome;Inflammation;Inflammatory;Interleukin-1 beta;knock-down;Knockout Mice;Macrophage;Malignant Neoplasms;MAPK8 gene;Mediating;MicroRNAs;Mus;Muscle;Muscle Fatigue;Muscle function;muscle strength;Muscle Weakness;Muscular Atrophy;Myocardium;Necrosis;neoplastic cell;novel;Organ;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Phosphorylation;Preparation;Prevalence;Property;Reporting;Role;side effect;Signal Transduction;Skeletal Muscle;Small Interfering RNA;Soleus Muscle;Source;stem cell exosomes;systemic inflammatory response;Teratoma;Testing;Therapeutic;Tissues;TLR4 gene;Toll-like receptors;Toxic effect;Translating;tumor;tumor growth;Xenograft Model

PROJECT_TITLE: Amelioration of Doxorubicin Induced Muscle Dysfunction with Embryoinic stem cells-Derived Exosomes


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The work proposed in this fellowship will reveal candidate pathways that are disrupted in sporadic PSP and has the potential to create a paradigm shift in disease model systems by revealing the extent to which iPSC- derived models recapitulate disease pathology in the human brain.

PI_NAMEs: WHITNEY, KRISTEN  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: 17q21;3-Dimensional;abeta accumulation;Alzheimer's Disease;Amyloid;Astrocytes;Autopsy;Behavioral;Biochemical;Biological Models;Brain;brain cell;brain tissue;Cell Death;Cells;Cellular Morphology;Clinical;clinical translation;Collection;Complex;Data;Development;Disease;disease model;Disease Progression;eIF2 Regulation Pathway;Endoplasmic Reticulum;endoplasmic reticulum stress;engineered stem cells;Environment;Event;Fellowship;Fibroblasts;gaze;Genetic;genome wide association study;Genomics;Gliosis;Goals;Histological Techniques;Human;human disease;human induced pluripotent stem cells;Image;Impaired cognition;induced pluripotent stem cell;innovation;insight;Laboratories;Learning Skill;MAPT gene;Measurement;Measures;Mentorship;Methods;Modeling;Molecular;monolayer;Morphology;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurologic Deficit;neuron loss;Neurons;neuropathology;novel;novel strategies;Organoids;Paralysed;Parkinsonian Disorders;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;Population;Positioning Attribute;Production;Progressive Supranuclear Palsy;Proteins;rare variant;Research;Research Personnel;response;Risk;Role;Secondary to;sensor;Series;skills;Specimen;Stains;stem cell biology;stem cell model;stem cell organoids;stressor;Syndrome;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;tool;Training;transcriptomics;Translational Research;Up-Regulation;Variant;Work

PROJECT_TITLE: The role of astrocytes in the pathogenesis of sporadic tauopathy


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: EAST LANSING

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE A fundamental trait of bacterial pathogens is the ability to scavenge essential nutrients from the host environment. Sulfur is a critical requirement for bacterial growth, but how Staphylococcus aureus acquires sulfur during infection is not known. The objective of this proposal is to establish the strategies utilized by S. aureus to obtain sulfur from the host environment, potentially revealing new therapeutic targets to combat antibiotic recalcitrant infections.

PI_NAMEs: HAMMER, NEAL D. (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: analog;Anatomy;Antibiotic Resistance;Antibiotics;Bacteremia;Biochemical;Catabolism;cell type;Chemicals;combat;comparative;Cysteine;Data;Development;Elements;Endocarditis;Environment;Enzymes;experimental study;Foundations;Gamma-glutamyl transferase;Generations;genetic approach;Genetic Screening;Glutathione;Glutathione Disulfide;Goals;Growth;Health;Homologous Gene;Human;Immune response;Impairment;In Vitro;in vivo;Infection;Infectious Skin Diseases;innovation;Iron;Knowledge;Libraries;Life;Liver;mass spectrometric imaging;Measures;Mediating;Metabolism;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutate;Nature;new therapeutic target;novel therapeutic intervention;Nutrient;Nutritional Requirements;Operon;Organ;Osteomyelitis;pathogen;Pathogenesis;pathogenic bacteria;Prevalence;Process;Proliferating;Reduced Glutathione;reverse genetics;Role;selenocystine;Soft Tissue Infections;Source;Spatial Distribution;Staphylococcus aureus;Sulfur;Support System;System;Systemic infection;Testing;Time;Tissues;trait;transcriptome sequencing;transcriptomics;Virulence;Work

PROJECT_TITLE: Elucidating strategies of Staphylococcus aureus nutrient sulfur acquisition during infection

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative Age-related alterations in attention likely contribute to changes in both spatial representation and episodic memory formation, negatively impacting goal-directed behaviors. The proposed research will leverage immersive virtual reality spatial paradigms along with behavioral and neural markers of attention to examine a) whether and how attention impacts spatial representation and navigation, b) how attention-mediated changes to spatial representation influence episodic memory encoding and memory integration, and c) how age-related cognitive change relates to disruptions in neural systems of attention and episodic memory, and their interactions.

PI_NAMEs: TRAN, TAMMY  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Affect;age difference;age related;age related changes;age related cognitive change;Aging;aging related;Alzheimer's Disease;Attention;attentional control;Attentional deficit;Behavior;behavior measurement;Behavioral;Calibration;Clinical;Code;Cognitive;Cues;Discrimination;Disease;Distal;Environment;Episodic memory;episodic memory impairment;Event;experience;experimental study;Functional Magnetic Resonance Imaging;Future;Goals;Impairment;Individual;Individual Differences;Knowledge;Knowledge acquisition;learned behavior;Learning;learning strategy;Link;locus ceruleus structure;Measures;medial temporal lobe;Mediating;member;Memory;memory encoding;Memory impairment;memory retrieval;method development;Modeling;neural;Neurocognitive;neuromechanism;Neurophysiology - biologic function;novel;older adult;Participant;Pattern;Performance;Play;Process;programs;Regulation;Research;Resolution;Retrieval;Role;scaffold;Scientific Advances and Accomplishments;selective attention;Series;spatial memory;sustained attention;System;Testing;Theoretical model;theories;Time;Training;virtual;virtual environment;virtual reality;virtual reality environment;visual tracking;way finding;young adult

PROJECT_TITLE: Utilizing naturalistic virtual environments to assess age-related alterations of attention and episodic memory


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative We aim to understand the pathogenesis of C9orf72 mutation-induced frontotemporal dementia (C9-FTD), a fatal and incurable neurodegenerative disease. C9-FTD involves the loss of specific neuron populations (vulnerable neurons) and the appearance of disease-associated microglia (pathologic microglia), but the molecular profiles of these cell types are unknown. This application proposes to identify the molecular profiles of vulnerable neurons and pathologic microglia as well as these cells’ spatial proximities and interactions in disease in order to define novel treatment targets for C9-FTD and potentially other neurodegenerative diseases.

PI_NAMEs: DAI, DAVID  (contact)

PROJECT_TERMS: Affect;Age;Appearance;Autopsy;Brain;C9ORF72;Cell Nucleus;cell type;Cells;Cessation of life;Chromium;clinical phenotype;Complex;Computational Technique;Cytoprotection;Data Set;Dementia;Development;Disease;Disease associated microglia;Disease Progression;Environment;excitatory neuron;excitotoxicity;Exhibits;extracellular;Female;Formalin;frontal lobe;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional disorder;Future;Gene Expression Profile;Genes;Genetic;Genomics;Glutamates;Goals;Histological Techniques;Histology;Human;human tissue;Immunofluorescence Immunologic;Immunohistochemistry;Individual;Induced Mutation;Induced Neurons;Inflammatory;Knockout Mice;Lead;Learning;Lesion;Location;male;Maps;Medial;Methods;Microglia;Molecular;Molecular Profiling;Mutation;Nerve Degeneration;neural network;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurologist;neuron loss;Neurons;neuropathology;novel;Paraffin Embedding;Pathogenesis;Pathologic;Patients;Phenocopy;Phenotype;Physicians;Population;protein TDP-43;Race;recruit;Research;resilience;response;RNA;Scientist;sex;single nucleus RNA-sequencing;Slide;Spatial Distribution;Stains;success;targeted treatment;Techniques;Temporal Lobe;Testing;Tissue Embedding;Tissues;Training;transcriptome;transcriptomics;Translational Research;Vulnerable Populations

PROJECT_TITLE: Characterizing Vulnerable Cell Types in C9orf72-FTD


ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE 4’-ethynyl-2-fluoro-2’-deoxyadenosine (EFdA, also known as MK-8591) is an extremely potent inhibitor of HIV, including drug-resistant viral strains, and blocks the virus by a different mechanism than all currently approved anti-HIV drugs. This project will determine the EFdA mechanism of action in the context of HIV infection in cells, and will also study the factors that affect development of high-level HIV resistance to EFdA, why certain HIV viruses that are resistant to other approved antivirals are hypersusceptible to EFdA, and address EFdA’s efficacy and resistance profile in various HIV subtypes. These studies will provide important insights on the design of combination therapies of EFdA with other approved antivirals leading to optimal treatments for HIV-infected patients around the world.

PI_NAMEs: SARAFIANOS, STEFAN G (contact)

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: 2'-deoxyadenosine;Acquired Immunodeficiency Syndrome;Action Potentials;Address;Adherence;Affect;analog;Animal Model;Anti-HIV Agents;Anti-viral Agents;antiretroviral therapy;Belief;Binding;Binding Sites;Biochemical;Biological Assay;Cell Culture Techniques;cell immortalization;Cell Line;Cells;Chronic;Clinic;Clinical;Combined Modality Therapy;Complex;Data;design;Development;Dose;Drug Combinations;Drug resistance;drug resistant virus;Event;Excision;experimental study;Funding;Generations;Genomics;Guidelines;HIV;HIV drug resistance;HIV Infections;HIV resistance;HIV therapy;In Vitro;inhibitor;inhibitor therapy;innovation;insight;Licensing;Modality;Multi-Drug Resistance;Mus;mutant;Mutation;Names;next generation;next generation sequencing;non-nucleoside reverse transcriptase inhibitors;nonhuman primate;novel;novel therapeutics;nucleoside analog;Nucleosides;Nucleotides;optimal treatments;Oral;Outcome;Paper;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;preclinical development;Prevention;Publishing;reconstitution;Research;Resistance;resistance mutation;Resistance profile;Reverse Transcriptase Inhibitors;Reverse Transcription;RNA-Directed DNA Polymerase;Site;Structure;System;Tenofovir;Testing;Time;United States National Institutes of Health;Vertebral column;Viral;viral DNA;Virus;Work;Zidovudine

PROJECT_TITLE: Ultrapotent Inhibitors of Wild-type and Multi-drug Resistant HIV

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: RELEVANCE (See instructions): HIV/AIDS is still a pandemic problem. Targeted innate immune therapies have yet to be developed against this virus. Fundamental research on molecular mechanisms regulating the antiviral APOBEC3 enzymes will stimulate the development of innovative HIV/AIDS therapeutics that work by leveraging this innate immune defense system to extinguish virus replication.

PI_NAMEs: HARRIS, REUBEN S (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Address;Affinity Chromatography;Biochemical;Biochemistry;Bioinformatics;Biological;Black Box;Cell Line;cell type;Cells;Cellular biology;Complementary DNA;Coupled;CRISPR library;Cytosine;Data Set;Deamination;Dedications;Development;enzyme activity;Enzymes;Epitopes;experimental study;Family member;Follow-Up Studies;fundamental research;Genetic;genetic approach;Genetic Screening;Genomics;Guide RNA;HIV;HIV-1;HIV/AIDS;Human;Immune;Immunotherapy;Infection;innovation;Instruction;Mass Spectrum Analysis;Mediating;Molecular;Molecular Virology;Monoclonal Antibodies;Mutation;next generation sequencing;novel strategies;pandemic disease;particle;Pathway Analysis;Pathway interactions;Patients;Phase;Phenotype;Process;protein protein interaction;Proteins;Proteomics;Regulatory Pathway;Reproducibility;Reverse Transcription;RNA;RNA Binding;Series;System;Therapeutic;tool;Uracil;Viral;Viral Physiology;virology;Virus;Virus Assembly;Virus Replication;Work

PROJECT_TITLE: APOBEC3 Proteins in HIV Restriction

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Triple Negative Breast Cancer (TNBC) is an aggressive disease with limited treatment options, and less than 30% of patients with TNBC will survive beyond five years after diagnosis. This project seeks to prove that mitochondrial manipulation is an effective strategy to repolarize macrophages into an anti-tumor state. The results may provide insights towards strengthening and advancing the use of immune therapies in a poor- prognosis cancer.

PI_NAMEs: CHAN, HILDA LYN (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Adopted;Aerobic;angiogenesis;Anti-Inflammatory Agents;breast cancer survival;Cancer Etiology;Cancer Prognosis;cancer subtypes;Categories;Cell Physiology;Characteristics;chemotherapy;Classification;Complex;cytotoxic;cytotoxicity;Data;Development;Diagnosis;differentiation in vitro;Disease;Drug resistance;drug-sensitive;Electron Transport;Elements;Endocrine;Environment;Etiology;experience;flexibility;Foundations;Gene Expression;Gene Expression Profile;Genes;Glycolysis;Goals;Growth;Human;Immune;immune cell infiltrate;immune checkpoint blockade;immunogenic;immunogenicity;Immunotherapy;Impairment;In Vitro;in vivo;Inflammatory;innovation;insight;Longevity;Macrophage;Malignant Breast Neoplasm;mammary;Mediating;Metabolic;Metabolism;Methods;Mitochondria;Modeling;Molecular;Mus;Neoplasm Metastasis;novel;Oxidative Phosphorylation;Pathway interactions;Patients;Periodicity;Phenotype;Population;Positioning Attribute;preference;Prognosis;programs;protein expression;Regulation;Resistance;respiratory;Role;Structure;success;T-Lymphocyte;Testing;Therapeutic;therapeutic target;transplant model;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor stage;Tumor-associated macrophages;tumor-immune system interactions;Tumor-infiltrating immune cells;Women's mortality;Work

PROJECT_TITLE: Combating the Immunosuppressive Tumor Microenvironment in Triple Negative Breast Cancer: The Role of Mitochondrial Dynamics in the Polarization of Tumor-Associated Macrophages


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: More than 60,000 refugees resettled in the Western countries in 2016, of whom 50% are children and adolescents. Devastating war has affected millions of civilians for decades in Iraq, and for nearly a decade in Syria, leading to a refugee crisis. The ultimate goal of the proposed research is to combine developmental psychopathology and biological data to inform the development of novel and effective assessment and treatment approaches in high risk children and adolescents from refugee populations.

PI_NAMEs: JAVANBAKHT, ARASH  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: accelerated epigenetic aging;Adolescent;Adult;Affect;Age;Anxiety;anxiety symptoms;Arabs;Arousal;Behavioral;Biological;Biological Factors;Biological Markers;Child;Child Development;Child Rearing;Childhood;Chronic;cohort;Collection;Country;Data;depressive symptoms;Development;DNA;DNA Methylation;Environmental Impact;Environmental Risk Factor;environmental stressor;epigenetic aging;Epigenetic Process;Exposure to;follow-up;Future;Galvanic Skin Response;Genes;genome-wide;Glucocorticoids;Goals;Health Services;Heterogeneity;high risk;Immigrant;improved;Intervention;Iraq;Knowledge;longitudinal course;longitudinal, prospective study;Measures;Mental Depression;Mental Health;Michigan;migration;Neurobiology;novel;Outcome;Parents;Patient Self-Report;Pediatric cohort;pediatric trauma;Peripheral;physical conditioning;Population;Post-Traumatic Stress Disorders;Procedures;Psychopathology;recruit;Refugee Camp;Refugees;Research;resilience;response;Retrospective Studies;Risk;Risk Factors;Risk Reduction;Saliva;Sampling;Severities;Siblings;Stress;stressor;Sympathetic Nervous System;Symptoms;Syria;Time;transmission process;Trauma;trauma exposure;traumatic stress;United States;War;Work

PROJECT_TITLE: Biological and Environmental Factors Affecting Risk and Resilience Among Syrian Refugee Children

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


PHR: OVERALL - PROJECT NARRATIVE In 2020, there will be an estimated 1.8 million new cancer cases diagnosed and 606,520 cancer deaths in the United States (source: American Cancer Society). The Karmanos Cancer Institute is a not-for-profit, cancer- only research and patient care organization whose mission is to be a transformative leader in cancer care, research, and education through courage, commitment and compassion. Key to achieving this mission is KCI’s research effort, which is conducted among four transdisciplinary Programs, organized to integrate basic, translational, and clinical research with population research-based cancer control activities.

PI_NAMEs: PASCHE, BORIS  (contact)

PROGRAM_OFFICER_NAME: PTAK, KRZYSZTOF

PROJECT_TERMS: Address;African American;African American population;American Cancer Society;anti-cancer research;Area;Attention;Basic Science;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Hospital;Cancer Intervention;Cancer Patient;cancer risk;care delivery site;care providers;Caring;Catchment Area;Censuses;Cessation of life;Cities;Clinic;clinical care;Clinical Research;Communication;Communities;Compassion;Comprehensive Cancer Center;County;Devices;Diagnosis;Disparity;Early Diagnosis;Economically Deprived Population;Education;Epidemiology;ethnic minority;Ethnic Origin;Etiology;Family;Foundations;fundamental research;Funding;Future;Goals;Grant;Healthcare;Home;Household;Income;Institution;Intervention;Invaded;Laboratory Research;Location;Malignant Neoplasms;Medically Underserved Area;member;metropolitan;Michigan;Minority;Minority Enrollment;Minority Groups;Mission;Modeling;Molecular;molecular imaging;Morbidity - disease rate;mortality;multidisciplinary;National Clinical Trials Network;new technology;novel therapeutics;operation;participant enrollment;Pathway interactions;Patient Care;patient engagement;Patients;Peer Review;Persons;Physicians;Population;Population Heterogeneity;Population Research;Population Study;Poverty;Prevention;Process;programs;Protocols documentation;Public Health;Quality of Care;Race;racial minority;Research;Research Contracts;Research Institute;Research Personnel;Research Project Grants;Resource Sharing;Resources;Secure;social disparities;socioeconomic disadvantage;Socioeconomic Factors;Source;suburb;success;Therapeutic;Therapeutic Intervention;Therapeutic Studies;Tissues;tool;Translational Research;treatment center;Treatment Protocols;Tumor Biology;tumor microenvironment;United States;United States Health Resources and Services Administration;Universities;Work

PROJECT_TITLE: CANCER CENTER SUPPORT GRANT


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: PIASENTIN, EVANO  (contact)

PROJECT_TERMS: Achievement;Address;anti-cancer research;Area;Award;Basic Science;Budgets;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer Science;Communication;community center;Continuing Education;Data;data management;Databases;Decision Making;Development;Direct Costs;Discipline;disparity reduction;Documentation;Environment;experience;Extramural Activities;Faculty;Fostering;Funding;Goals;Grant;Home;Immunology;Immunotherapy;Infrastructure;Intervention Studies;Laboratories;laboratory equipment;Leadership;Maintenance;Malignant Neoplasms;Marketing;meetings;member;metabolomics;Michigan;Mission;Monitor;operation;Pilot Projects;Play;Policies;Process;programs;Prostate;Publications;Recommendation;recruit;Reporting;repository;Research;Research Personnel;Resource Development;Resource Sharing;Resources;Risk;Role;Science;Scientist;Services;shared decision making;skills;Strategic Planning;Surveys;survivorship;tumor metabolism;Vision

PROJECT_TITLE: Cancer Center Administration


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Grand mal seizures, also called generalized tonic clonic seizures, can kill persons with epilepsy. We study the effects of these seizure on structure and function of the motor cortex, in animal models of temporal lobe epilepsy.

PI_NAMEs: KAPUR, JAIDEEP  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: AMPA Receptors;Animal Model;Animals;Area;Behavioral;Biochemical;Brain;Cause of Death;Cell Count;conditional knockout;Data;dentate gyrus;Development;eighth grade;Electroencephalography;Electrophysiology (science);Epilepsy;Estrogen Receptors;Exhibits;Experimental Models;experimental study;FDA approved;FOS gene;Fracture;Fright;Genetic Recombination;Glutamates;hippocampal pyramidal neuron;Hippocampus;Image;Immediate-Early Genes;Injury;insight;Investigation;kainate;knockout animal;Knockout Mice;Lasers;Long-Term Potentiation;Maps;Mediating;Methods;Microscope;Modeling;Molecular;Monitor;Motor Cortex;motor learning;Motor Skills;Mus;Neocortex;neocortical;Neurons;novel;patch clamp;Patients;Pentylenetetrazole;Persons;Pharmaceutical Preparations;Population;postsynaptic;promoter;Property;Prosencephalon;Proteins;Refractory;Reporter;Research;response;Risk;Risk Factors;Role;Seizures;Seminal;skill acquisition;Slice;Soft Tissue Injuries;Status Epilepticus;Stimulus;Structure;sudden unexpected death in epilepsy;Synapses;Techniques;Temporal Lobe Epilepsy;Testing;therapeutic target;third grade;Tonic - clonic seizures;transmission process

PROJECT_TITLE: Motor cortex plasticity in temporal lobe epilepsy


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative  Alzheimer’s disease (AD) currently affects millions nationally with no clearly effective treatment that can target disease pathology. This proposal utilizes biophysical, structural and cell biological techniques to test a novel hypothesis that will aide our fundamental understanding of unique structure-function relationships of the protein tau by studying its canonical and disease-associated interactions. Our research will contribute to the field’s understanding of the mechanistic changes in tau behavior that drive AD and other tauopathies and will facilitate the development of novel therapeutic targets for the treatment of tau-based neurodegeneration.

PI_NAMEs: MANCINELLI, CHIARA DIAMANTE (contact)

PROJECT_TERMS: Acetylation;Actins;Address;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Amyloid beta-Protein;Automobile Driving;Behavior;Binding;Biological;Biological Assay;biophysical techniques;Biophysics;Brain;Bundling;Cells;Cellular Assay;Chemicals;Clinical Trials;Cognitive;Data;design;Development;Disease;effective therapy;experimental study;F-Actin;Hyperemia;Impaired cognition;improved;In Vitro;Letters;Lysine;Maps;Mediating;Microfilaments;Microtubule Stabilization;mimetics;monomer;mutant;Mutation;N-Methyl-D-Aspartate Receptors;N-terminal;Nerve Degeneration;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;neuron loss;neurotoxicity;new therapeutic target;NMR Spectroscopy;novel;Nuclear Magnetic Resonance;Pathologic;Pathology;Phosphorylation;Physiological;Play;Post-Translational Protein Processing;postsynaptic density protein;pre-clinical;Process;Proteins;Receptor Activation;Reporting;Research;Resolution;Role;Sampling;Sedimentation process;Senile Plaques;Side;Structure;Structure-Activity Relationship;tau aggregation;tau function;tau interaction;tau microtubule binding domain;tau Proteins;tau-1;tau-microtubule interaction;Tauopathies;Techniques;Testing;Therapeutic;Vertebral column

PROJECT_TITLE: Elucidating the Effects of Post-Translational Modifications on Tau Binding to F-actin and PSD95


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: SHREVEPORT

ORG_DEPT: PHARMACOLOGY

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: Project Narrative Alcoholism is chronically relapsing disorder characterized by behavioral, cognitive, and neurobiological dysfunctions. The importance of the cholinergic circuits of the brain in alcoholism is accepted and has been studied; however, few of these studies have examined the striatal cholinergic interneurons, including any potential subtypes. Therefore, the experiments proposed in this project will lead to a better understanding striatal cholinergic interneurons broadly, and more specifically, how they are affected by acute and chronic alcohol.

PI_NAMEs: SALINAS, ARMANDO  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Ablation;Acute;addiction;Address;Advisory Committees;Affect;Agreement;Alcohol consumption;alcohol craving;alcohol effect;alcohol exposure;alcohol seeking behavior;alcohol sensitivity;Alcoholism;Alcohols;Anatomy;Attention;Basal Ganglia;Behavior;Behavioral;behavioral phenotyping;Biochemical;Biological Assay;Brain;Brain region;career;Cell Count;Cellular Morphology;chemical property;cholinergic;Cholinergic Agonists;cholinergic neuron;Chronic;Cognitive;Cognitive deficits;Corpus striatum structure;Data;design;designer receptors exclusively activated by designer drugs;Desire for food;Disease;Dopamine;Educational process of instructing;Electrophysiology (science);Ethanol;experimental study;Exposure to;Extramural Activities;Faculty;Functional disorder;genetic manipulation;Glutamates;Impaired cognition;Impairment;improved;Impulsive Behavior;in vivo;Institution;interest;Interneuron function;Interneurons;Learning;Light;Literature;Macaca mulatta;Manuscripts;Mentors;Mentorship;Monkeys;Mus;National Institute on Alcohol Abuse and Alcoholism;Neurobiology;Neurons;Performance;Positioning Attribute;preference;problem drinker;Process;Property;Psychological reinforcement;Regulation;Relapse;Research;Research Personnel;Reversal Learning;Rewards;Role;Running;Scientist;Self Administration;skills;Source;Synaptic plasticity;System;Techniques;Testing;Training;Transgenic Mice;Universities;vapor;varenicline

PROJECT_TITLE: Chronic ethanol effects on cholinergic interneurons of the striatum


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Cancer;Genetics;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Urologic Diseases

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative This proposal will elucidate the DNA damage response properties of testicular germ cell tumors (TGCTs) and the cells from which they arise, which will inform the mechanisms underlying their remarkable sensitivity to conventional genotoxic chemotherapy. Understanding the basis of TGCT chemosensitivity will apply broadly to the development of treatments for the many other cancers that do not respond favorably to chemotherapy. Additionally, investigating the malignant transformation of pluripotent cells will be important for improving stem- cell based therapies, which carry the risk of tumorgenicity.

PI_NAMEs: LOEHR, AMANDA  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Aftercare;Alleles;Anchorage-Independent Growth;Apoptosis;Breast Carcinoma;Candidate Disease Gene;Cell Cycle Arrest;Cell Differentiation process;cell transformation;cell type;Cells;Chemoresistance;chemotherapy;Colon Carcinoma;Comet Assay;Development;DNA biosynthesis;DNA Damage;DNA fiber assay;DNA Repair;DNA Replication Timing;DNA Sequence Alteration;Embryo;Embryonal Carcinoma;Embryonal Carcinoma Cell;Embryonic Development;Enterobacteria phage P1 Cre recombinase;Event;Exercise;experience;experimental study;Fibroblasts;Generations;Genes;Genetic Recombination;Genetically Engineered Mouse;Genome;genotoxicity;Germ Cells;Human;improved;In Situ;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Lesion;Lung Carcinoma;Malignant - descriptor;Malignant Neoplasms;Measures;Modeling;mouse model;Mus;Mutagens;Mutate;Mutation;Nature;Neoplasms;neoplastic cell;Oncogene Activation;Oncogenes;Oncogenic;Pathology;Pathway interactions;Phenotype;Pluripotent Stem Cells;pressure;prevent;Proliferating;Property;repaired;replication stress;response;Risk;Risk Reduction;Role;Signal Transduction;Somatic Cell;Spermatocytes;stem cell biomarkers;stem cell therapy;Structure of primordial sex cell;System;Teratocarcinoma;Teratoma;Testicular Germ Cell Tumor;Testicular malignant germ cell tumor;Testicular Neoplasms;Therapeutic;therapy development;Tissue-Specific Gene Expression;Tissues;transcriptome sequencing;treatment response;tumor;tumor initiation;tumor progression;Tumor Suppressor Genes;tumorigenesis;Tumorigenicity;Undifferentiated;young man

PROJECT_TITLE: The role of the DNA damage response in the development and therapeutic sensitivity of malignant testicular germ cell tumors.


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Pediatric;Post-Traumatic Stress Disorder (PTSD);Substance Misuse;Underage Drinking

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: 8. PROJECT NARRATIVE The data collected from the proposed studies will increase not only our understanding of the behaviors associated with alcoholism and PTSD comorbidity, but also how alcohol use during adolescence may alter a person's ability to successfully cope with a traumatic event later in life that can lead to PTSD and abuse of alcohol. The findings will also provide a better understanding of the brain changes associated with these disorders that will help develop new and more effective treatments.

PI_NAMEs: CHANDLER, L JUDSON (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent alcohol abuse;adolescent alcohol exposure;Adult;Age of Onset;Alcohol abuse;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol relapse;alcohol seeking behavior;alcohol use disorder;Alcoholism;Amygdaloid structure;Anxiety Disorders;Behavior;Behavior Control;Behavioral;biological adaptation to stress;Brain;Brain region;Characteristics;clinically relevant;cognitive process;Communication;comorbidity;Complex;conditioned fear;coping;critical period;Cues;Data;design;Development;Disease;drinking behavior;effective therapy;Electrophysiology (science);emerging adult;Ethanol;Event;Exhibits;experience;experimental study;Exposure to;Extinction;Financial Hardship;Fright;GRM5 gene;heart rate variability;High Prevalence;high risk;Human;in vivo;Individual;Inhalation;innovation;interest;Knowledge;Learning;Life;male;Measures;Medial;Mediating;memory process;Mental disorders;Modeling;neural circuit;neuromechanism;Neurons;neuropathology;novel;optogenetics;Patients;Persons;pharmacologic;Phase;Physiological;Play;Post-Traumatic Stress Disorders;Predisposition;Prefrontal Cortex;Procedures;Rattus;receptor;Recording of previous events;Research;Risk;Risk Factors;Role;Self Administration;sensor;Sex Differences;Site;social;Stimulus;Stress;Stress and Coping;stress reduction;stress resilience;Testing;traumatic event;traumatic stress;underage drinking;vapor

PROJECT_TITLE: Adolescent Alcohol Abuse, Traumatic Stress, and Vulnerability to Development of PTSD

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Given that the current cost of Alzheimer’s Disease (AD) and dementia care is currently estimated at over $216 billion annually, treatments to delay or prevent AD-related cognitive decline would alleviate the immense financial burden and emotional toll currently facing patients and caregivers. However, without a better understanding of the genetic and neuronal mechanisms that underly AD, development of these treatments will not be possible. In the short term, I will determine if the gene Dlgap2 is a genuine mediator of AD-related cognitive decline and provide insight into dendritic spines as a therapeutic target of AD; in the long term, I will develop a better understanding of the synaptic mechanisms that contribute to AD and build a framework for future AD research.

PI_NAMEs: OUELLETTE, ANDREW  (contact)

PROJECT_TERMS: Age;age difference;Age Months;Age-associated memory impairment;aged;Aging;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Antibodies;Behavioral Assay;biocytin;Biological;career;career development;Caregivers;causal variant;Cells;Closure by clamp;Cognition;Cognitive;Cognitive aging;Cognitive deficits;cognitive enhancement;cognitive performance;cognitive task;cohort;Communication;Complementary DNA;conditioned fear;cost;Coupling;Data;dementia care;Dendritic Spines;density;Dependovirus;design;Development;Electrophysiology (science);Emotional;Excitatory Postsynaptic Potentials;experimental study;Financial Hardship;Fostering;Functional disorder;Future;gene discovery;Gene Expression;Genes;Genetic;genetic variant;Goals;Health;Hemagglutinin;Heritability;hippocampal pyramidal neuron;Hippocampus;Human;Image;Impaired cognition;Individual Differences;Injections;insight;Intervention;Knowledge;Label;long term memory;Long-Term Potentiation;Longevity;Measures;Mediator;microscopic imaging;Microscopy;Modification;Morphology;mouse genetics;mouse model;Mus;Neurons;new therapeutic target;novel strategies;Outcome;overexpression;Pathogenesis;Pathology;Pathway interactions;Patients;Play;Population;postsynaptic;postsynaptic neurons;Predisposition;prevent;promoter;protective effect;protein expression;Proteins;Publications;Publishing;rate of change;Reporting;Research;resilience;Resolution;Risk Factors;Role;Series;sex;Short-Term Memory;skills;Slice;Stains;Streptavidin;Structure;Synapses;synaptic function;Synaptic plasticity;System;Testing;Therapeutic;therapeutic target;therapy development;Thinness;touchscreen;Training;Vertebral column;Vision;Work

PROJECT_TITLE: Dlgap2 as a Regulator of Alzheimer's Disease Related Cognitive Declines Via Synaptic Modifications


NIH_SPENDING_CATS: Cancer

PI_NAMEs: COTE, MICHELE L. (contact)

PROJECT_TERMS: African American;American;anti-cancer research;Arabs;Area;Award;Awareness;Cancer Biology;cancer care;Cancer Center Support Grant;cancer education;Cancer health equity;cancer initiation;career;career development;Career Mobility;career networking;Catchment Area;Clinical;clinical care;Collaborations;Communities;community engagement;Community Health;Community Healthcare;Comprehensive Cancer Center;continuing medical education;Dedications;Development;Direct Costs;Education;Educational process of instructing;Educational workshop;effectiveness evaluation;Enrollment;Ensure;environmental stressor;Event;Faculty;Fellowship;Female;Fostering;Foundations;Funding;Funding Mechanisms;Future;Gerontology;Goals;graduate student;Health Personnel;Health Professional;high school;High School Student;Hispanic;Infrastructure;Internships;Leadership;leadership development;Malignant Neoplasms;Medical;medical schools;Medical Students;member;Mentors;Molecular Genetics;Molecular Medicine;next generation;Not Hispanic or Latino;novel;Patient Care;Physics;Policies;Postdoctoral Fellow;programs;Race;recruit;Reproducibility;Research;Research Personnel;Resources;response;Schools;Services;skills;Solid;Students;success;symposium;tenure track;Training;Training Activity;Training and Education;Training Programs;training project;Training Support;Translational Research;undergraduate student;United States National Institutes of Health;Universities;Update;Work

PROJECT_TITLE: Cancer Research Training and Education Coordination


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative  Previously our lab observed the accumulation of misfolded lysosomal hydrolases in the endoplasmic reticulum (ER), ER fragmentation, and an inability to induce the unfolded protein response (UPR) in dopamine neurons differentiated from Parkinson’s disease (PD) patients harboring mutations in alpha-synuclein. This failure to effectively clear aggregated proteins in the ER may in part be due to defects in the ER proteostasis pathway ER-phagy, a form of macroautophagy wherein regions of proteostatic stress in the ER are selectively degraded. We intend to test whether ER-phagy plays a role in PD pathogenesis, and if so, whether restoring functional ER-phagy can alleviate ER stress and improve neuronal survival.

PI_NAMEs: ZALON, ANNIE  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: age related;age related neurodegeneration;alpha synuclein;Autophagocytosis;Biochemical;Cells;Co-Immunoprecipitations;Defect;Dementia with Lewy Bodies;Disease;dopaminergic neuron;Dose;Electron Microscopy;Endoplasmic Reticulum;endoplasmic reticulum stress;Failure;Functional disorder;functional improvement;functional restoration;Genes;Genetic;genetic risk factor;Genetic study;genome wide association study;Genomic Segment;glucosylceramidase;Golgi Apparatus;Homeostasis;Hydrolase;immunocytochemistry;Impairment;improved;In Vitro;in vivo;Inclusion Bodies;induced pluripotent stem cell;insight;Laboratory Finding;Lewy Bodies;Link;Literature;loss of function mutation;Mass Spectrum Analysis;Measures;Mediating;Membrane;Midbrain structure;misfolded protein;Modeling;Morphology;Movement Disorders;Mutation;Nature;Neurodegenerative Disorders;Neuronal Differentiation;neuronal survival;Neurons;novel therapeutic intervention;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Persons;Phenotype;Play;Process;protein aggregation;Proteins;proteostasis;proteostasis loss;receptor;Resistance;response;Risk;risk variant;Role;Severities;SNCA gene;sporadic Parkinson's Disease;Stress;Structure;Symptoms;Techniques;Testing;Therapeutic;Toxic effect;trafficking;Variant;Vesicle;Western Blotting;Work

PROJECT_TITLE: The role of ER-phagy in maintaining protein homeostasis in PD patient derived neurons.


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Pediatric;Pregnancy;Rare Diseases;Women's Health Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative During pregnancy, Ebola Virus Disease (EVD) caused by infection with Zaire Ebola virus (EBOV), leads to ~100% loss of the fetus or neonate with or without the additional loss of the mother. This project will begin the process of understanding the pathogenesis of EBOV during pregnancy by determining the route and mechanisms of infection in placental tissues. This data from this project will add to the knowledge regarding viral infections in placental tissues and the barrier role of the placenta as well as the development of potential therapeutics or treatment protocols to improve the maternal and fetal outcomes of EVD.

PI_NAMEs: VAN ERT, HANORA ANNE MARIE (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: 2019-nCoV;Academic Medical Centers;Africa;Antigens;Binding;C Type Lectin Receptors;C-Type Lectins;Cell membrane;Cell surface;cell type;Cells;Cessation of life;Chorionic villi;Clinical;Communicable Diseases;Containment;Data;Dendritic Cells;Development;Discipline of obstetrics;Disease Outbreaks;Ebola Hemorrhagic Fever;Ebola virus;emerging pathogen;Endosomes;Endothelial Cells;Environment;Epithelial Cells;Evaluation;experience;Experimental Animal Model;Family member;Fellowship;fetal;Fetal Death;Fetal Development;fetal loss;Fetal Tissues;Fetus;fetus cell;Fibroblasts;Filoviridae Infections;Filovirus;Funding;Future;Glycoproteins;glycosylation;Goals;Health;Health Sciences;Human;human morbidity;human mortality;Immune response;Immunology;improved;In Vitro;in vivo;Individual;Infection;insight;Iowa;Knowledge;late endosome;Macrophage;Maternal-Fetal Exchange;Maternal-fetal medicine;member;Mentors;Mentorship;Microbiology;Modeling;monocyte;Mothers;Neonatal Mortality;neonate;Outcome;pathogen;Pathogenesis;Pathology;peripheral blood;Personal Satisfaction;Persons;phosphatidylserine receptor;Phosphatidylserines;Physicians;Placenta;placental infection;Play;Polysaccharides;Population;Positioning Attribute;Predisposition;Pregnancy;Pregnant Women;Process;Production;Productivity;receptor;Reproductive Health;Research;Research Design;Research Personnel;Residencies;RNA Viruses;Role;Route;Scientist;Series;skills;Source;symposium;Syncytiotrophoblast;Techniques;tenure track;Testing;Therapeutic;therapeutic development;Tissues;Training;training opportunity;transmission process;Transportation;Treatment Protocols;Tropism;Universities;Viral;Viral Hemorrhagic Fevers;Viral Pathogenesis;viral RNA;viral transmission;Viremia;Virion;virology;Virus;Virus Diseases;Virus Replication;Woman;Work;Zaire Ebola virus;Zika Virus

PROJECT_TITLE: Determining Tropism and Mechanisms of Ebola Virus Entry in Placental Tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-M(20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Alzheimer disease is the most common cause of dementia with no clearly effective disease modifying therapies. Alterations in glial lipid metabolism have been shown to be central to AD pathogenesis, and the present study is designed to evaluate the effects of modulating microglial lipid buffering capacity on inflammation and disease progression in a mouse model of tauopathy. Our findings will inform the development of novel classes of microglia-targeted therapies that may slow the progression of neurological diseases characterized by aberrant lipid metabolism like AD.

PI_NAMEs: TABOR, GEORGE TRAVIS (contact)

PROJECT_TERMS: abeta accumulation;Acceleration;Address;Adipocytes;Adopted;Affect;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease risk;Alzheimer's disease therapy;Amyloid;Amyloid beta-Protein;Amyloidosis;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;arm;Astrocytes;Autopsy;Biogenesis;Biological;biomarker identification;Brain;Brain region;Buffers;Cell Physiology;cell type;Cells;Clinical Trials;CNS degeneration;Complement;Coupled;cytokine;Cytoprotection;Dementia;density;design;Development;diacylglycerol O-acyltransferase;differential expression;Disease;Disease Progression;endoplasmic reticulum stress;Enzymes;Exhibits;extracellular;Fatty Acids;Genes;Genetic;Genetic Risk;Genetic Transcription;Genotype;Goals;Human;Hypoxia;Inflammation;Inflammatory;insight;Intervention;Knock-out;Knowledge;Late Onset Alzheimer Disease;lipid metabolism;lipidomics;Lipids;Lipolysis;Literature;Membrane;Microglia;Mitochondria;Modeling;mouse model;Mus;Myelogenous;Nerve Degeneration;Nervous System Disorder;Neurofibrillary Tangles;Neuroglia;novel;old mice;Pathogenesis;Pathologic;Pathway Analysis;Pathway interactions;Persons;Phagocytes;Phagocytosis;pharmacologic;Phase;Phenotype;Play;preclinical study;Predisposing Factor;Process;Production;Protein Isoforms;response;Role;Sampling;Senile Plaques;Shapes;single-cell RNA sequencing;Stains;Stress;targeted treatment;tau aggregation;tau Proteins;Tauopathies;Therapeutic;Time;Tissues;Toxic effect;transcriptome;transcriptomics;United States;Variant

PROJECT_TITLE: Elucidating roles of microglial lipid droplets in neurodegeneration


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease

ORG_CITY: NEW YORK

PHR: PROJECT NARRATIVE This project aims to delineate the function roles of Hdac4 and Hdac7 in Th17 cell development and inflammatory bowel diseases. The outcome will empower the research community to better understand the fundamental molecular basis of Th17 cell transcriptional program and pathogenicity, and will have great implications in human health and autoimmune diseases, particularly inflammatory bowel diseases.

PI_NAMEs: CHEUNG, KALUNG  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: adaptive immunity;Autoimmune Diseases;Bacterial Infections;Binding;C-terminal;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Lineage;Cell Maintenance;cell type;Cells;Chemicals;ChIP-seq;Chromatin;Colitis;Colon;Colonic inflammation;Communities;Complex;cytokine;Data;Development;Disease;effective therapy;empowerment;Enzymes;gene repression;Genes;genetic approach;Genetic Markers;Genetic Transcription;gut inflammation;HDAC4 gene;HDAC7 histone deacetylase;Health;Helper-Inducer T-Lymphocyte;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;IL10 gene;IL17 gene;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inhibitor;interleukin-23;Interleukin-6;Lamina Propria;Malignant Neoplasms;Maps;Mediating;mesenteric lymph node;migration;Modeling;Molecular;Mucous Membrane;Multiple Sclerosis;murine colitis;Mus;Mycoses;N-terminal;novel;novel therapeutic intervention;Nucleic Acid Regulatory Sequences;Outcome;Pathogenicity;Patients;pharmacologic;Physiological;Play;programs;Proteins;recruit;Regulation;Regulator Genes;Regulatory Element;Regulatory T-Lymphocyte;Repression;Research;Rheumatoid Arthritis;Role;Signal Pathway;single-cell RNA sequencing;T-Cell Development;T-Lymphocyte;Therapeutic;transcription factor;Transcriptional Regulation;transcriptome sequencing;translational potential;virulence gene

PROJECT_TITLE: Role of Class IIa HDACs HDAC4 and HDAC7 in Pathogenic Th17 Cell Development and Colitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(57)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Alcoholism imposes a substantial public health burden but is poorly controlled therapeutically. The lack of effective therapies stems from a poor basic understanding of how the brain perceives alcohol as a rewarding substance. To this end, this research seeks to uncover a new mechanism of alcohol reward to vertically inform therapeutic strategies targeting alcoholism.

PI_NAMEs: MATHUR, BRIAN NEIL (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Address;Alcohol consumption;alcohol effect;alcohol exposure;alcohol misuse;alcohol reward;alcohol use disorder;Alcoholism;Alcohols;Area;Automobile Driving;behavior prediction;Brain;Brain-Derived Neurotrophic Factor;cell type;Chronic;chronic alcohol ingestion;chronic pain;comorbidity;conditioned place preference;Consumption;Data;Disease;Disinhibition;drinking behavior;Dynamin;effective therapy;Electrophysiology (science);Enhancers;Ethanol;Fostering;Functional disorder;Genetic;Goals;in vivo;Inhibitory Synapse;innovation;insight;Investigation;knock-down;Knowledge;Long-Term Depression;Mediating;Mental Depression;Molecular;Motivation;neural circuit;Neurons;neuropsychiatric disorder;novel;Nucleus Accumbens;optogenetics;Output;Pathologic;pharmacologic;Positioning Attribute;postsynaptic;preference;Prefrontal Cortex;Property;Protein Tyrosine Kinase;Public Health;receptor;Receptor Protein-Tyrosine Kinases;Research;Rewards;Role;Signal Transduction;Slice;Source;stem;Structure;Synapses;Synaptic plasticity;Synaptic Transmission;System;Testing;Therapeutic;tool;treatment strategy;vapor;Ventral Tegmental Area;Viral

PROJECT_TITLE: Synaptic Mechanisms of Nucleus Accumbens Disinhibition by Ethanol


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_STATE: MI

PI_NAMEs: WAGNER, KAY-UWE  (contact)

PROJECT_TERMS: Ablation;Address;anti-tumor immune response;Basic Science;Biological Process;Bispecific Antibodies;cancer cell;Cancer Center;Cancer Center Support Grant;cancer survival;Catchment Area;Cell Communication;Cells;Characteristics;chimeric antigen receptor T cells;Clinical;clinical application;clinical investigation;Clinical Markers;Clinical Research;Clinical Treatment;Collaborations;Cyclic GMP;design;Development;diagnostic strategy;Disease;DNA Vaccines;Epigenetic Process;Experimental Models;extracellular;Extracellular Matrix;Genes;Genetic;Genetic study;Goals;Grant;Growth;Human;imaging modality;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immunomodulators;immunoregulation;Immunotherapeutic agent;Immunotherapy;Inherited;innovation;Institution;Intervention;Invaded;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;Mediating;member;Metabolic;metastatic process;Michigan;Mission;Molecular;molecular imaging;Monitor;multidisciplinary;Mutation;neoplasm immunotherapy;Neoplasm Metastasis;neoplastic cell;Neoplastic Cell Transformation;Normal tissue morphology;novel;novel therapeutic intervention;Oncogenes;Organ;paracrine;Paracrine Communication;Peer Review;Phase;pre-clinical research;preclinical study;Process;programs;Proliferating;Proteolysis;Publishing;Research;Research Activity;Research Personnel;response;Schools;Science;Signal Pathway;Signal Transduction;Site;Specimen;Stem cell transplant;Stromal Cells;success;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Tracer;Translational Research;Treatment Protocols;treatment strategy;tumor;Tumor Biology;Tumor Cell Invasion;Tumor Markers;tumor microenvironment;tumor progression;Tumor Suppressor Genes;Tumor-Derived;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;Universities;Work

PROJECT_TITLE: Tumor Biology and Microenvironment