NIH_SPENDING_CATS: Hearing Loss;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE Hearing loss is a prevalent but under-addressed health condition; social, historical and cultural determinants of health must be addressed to advance hearing health. New data-intensive approaches to science can be leveraged to uncover individual and societal causes and consequences of hearing impairment, and the effectiveness of interventions on a large scale. The Population Hearing Health Care (PopHHC) conference promotes inter- disciplinary research with big data to advance and translate knowledge to improve the lives of those living with hearing loss.

PI_NAMEs: HOOD, LINDA J. (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Academy;Address;Adult;Advocate;Aging;Area;Award;Big Data;Caring;Communication;community intervention;community involvement;Country;Data;Databases;Dementia;Development;Discipline;Discipline of Nursing;Disease;Ear;Early identification;Early Intervention;Effectiveness of Interventions;Epidemiology;Etiology;evidence base;Future;Future Generations;Gerontology;Goals;Growth;Health;Health Care Research;health determinants;Healthcare;Healthcare promotion;Hearing;hearing impairment;Impaired cognition;improved;Individual;Infrastructure;innovation;interdisciplinary collaboration;Interdisciplinary Study;interest;intervention program;Investigation;Knowledge;large datasets;Life Cycle Stages;meetings;Mentors;Methodology;Modeling;National Institute on Deafness and Other Communication Disorders;next generation;Nongovernmental Organizations;Participant;Pediatrics;Persons;Population;population health;Population Research;prevent hearing loss;Primary Care;Production;psychologic;Public Health;recruit;Research;Research Methodology;Research Personnel;Research Support;Resources;response;Science;Series;social;Students;symposium;synergism;Technology;tool;Training;Translating;Travel;virtual;Work

PROJECT_TITLE: Annual Meeting of the Population Hearing Health Care (PopHHC) Network

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: DALLAS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: NARRATIVE p53 genes are widely implicated in age-related disease. We discovered that core ancestral properties of these genes act to restrict transposons, which are also broadly implicated in sporadic and heritable pathologies. Initiatives in this proposal will determine how p53 functions to contain these mobile elements.

PI_NAMEs: ABRAMS, JOHN M (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Acute;Address;Age related pathologies;age-related disease;Alleles;Animals;Apoptosis;Binding;biological adaptation to stress;Biology;Biology of Aging;Biosensor;Cancer Patient;cancer prevention;cell growth;cell injury;Cells;Chimera organism;Chromatin;Clinic;Code;Complement;Defect;Deposition;Diagnosis;disabled;Disease;DNA Repair;Drosophila genus;Elements;Epigenetic Process;Fishes;fly;Gene Family;Genes;Genetic;Genetic Models;Genetic Transcription;Genome;genome-wide;Goals;Health;Heritability;Human;human disease;Human Pathology;Hyperactivity;improved;in vivo;Individual;innovation;insight;Link;loss of function;Malignant Neoplasms;Mediating;Modality;Modeling;Molecular;Mus;mutant;Mutant Strains Mice;Mutate;Oncogenic;Pathology;Phenotype;Positioning Attribute;prevent;Process;Proliferating;Property;Protein Isoforms;Proteins;reconstitution;Regulation;Reporting;Repression;Resources;response;restraint;Retroelements;Retrotransposon;Route;senescence;Specific qualifier value;Stress;System;Time;tool;TP53 gene;Trans-Activators;transcription factor;Transcriptional Activation;tumor;Tumor Suppression;virtual;Visualization

PROJECT_TITLE: Suppression of mobile elements by p53 genes

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Palliative Care;Post-Traumatic Stress Disorder (PTSD);Prevention;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Telehealth;Transplantation

ORG_CITY: DURHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: An evidence‐informed, individually-tailored mobile health (mHealth) solution that is available at no cost and is effective in managing posttraumatic stress disorder symptoms could help improve the public health of thousands of stem cell transplant cancer survivors. Those who are low-income and/or are nonwhite are at greatest risk for poor outcomes and stand the greatest chance to benefit. In fact, what is learned in the proposed study could be applied to other cancer centers and thereby lead to improved quality of life in other oncology populations and reduced healthcare costs.

PI_NAMEs: SMITH, SOPHIA K. (contact)

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: adaptive intervention;Address;Allogenic;Anxiety;Applications Grants;Area;Autologous;Cancer Center;cancer diagnosis;Cancer Survivor;cancer therapy;Caring;Characteristics;clinically significant;Cognitive Therapy;Collaborations;Consent;Control Groups;cost;cost effective;Coupling;Data;Data Collection;Development;Diagnosis;Distress;effective therapy;Effectiveness;effectiveness evaluation;electronic data;Eligibility Determination;Ensure;experience;Goals;Health Care Costs;Hematopoietic Stem Cell Transplantation;high risk;Impaired health;improved;improved outcome;Income;Individual;individual patient;individualized medicine;innovation;Intensive Care;Intervention;Knowledge;Lead;Learning;Location;Low income;Malignant Neoplasms;Memory;Mental Health Services;Methods;mHealth;mhealth interventions;mobile application;Modeling;novel;Numbness;Oncology;Outcome;Participant;patient response;Patients;personalized medicine;Persons;Pilot Projects;Population;post intervention;Post-Traumatic Stress Disorders;prevent;Process;programs;Protocols documentation;Public Health;Quality of life;Race;Randomized;Recommendation;reduce symptoms;Regimen;Research;Research Personnel;Resources;Risk;screening;Self Management;Sequential Multiple Assignment Randomized Trial;sex;Sleep disturbances;Specific qualifier value;Stem cell transplant;Surveys;Survivors;symptom management;Symptoms;Testing;Time;tool;transplant survivor;Transplantation;transplantation therapy;Travel;treatment as usual;Treatment Protocols;Treatment-Related Cancer;trial design;United States Department of Veterans Affairs;Videoconferencing;wasting;Work

PROJECT_TITLE: Using a SMART Design to Optimize PTSD Symptom Management Strategies Among Cancer Survivors

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: COLUMBIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Endocrine disrupting chemicals (EDCs) can influence epigenetic reprogramming of germ cells by establishing epigenetic aberrations, also called epimutations, with adverse health outcomes in later generations. The proposed study will identify unique estrogenic chemical (bisphenol A, BPA)- induced epimutations and correct them with nutritional supplements and epigenome editing tools to restore normal health from transgenerational phenotype. The information from this study will provide insights into transgenerational health risks due to EDC exposure during early embryonic life and contributes to development of strategies for management of transgenerational health risks in future generations.

PI_NAMEs: BHANDARI, RAMJI KUMAR (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: 20 year old;Adult;Age;Androgen Receptor;Animal Model;bisphenol A;bisulfite sequencing;Chemical Exposure;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;CpG Islands;Crossbreeding;Databases;Defect;Development;dietary supplements;Disease;DNA;DNA Methylation;egg;Embryo;Endocrine Disruptors;Environment;environmental chemical;Epigenetic Process;epigenome;epigenome editing;epitranscriptome;estrogenic;Exposure to;Failure;Female;Fertility;Fertilization;Fishes;Future;Future Generations;gastrulation;Gender;Generations;genome-wide;Germ Cells;Germ Lines;Goals;Gonadal structure;Health;Histologic;histone modification;Human;Impairment;in vivo;Incidence;Individual;Inherited;insight;interest;Japanese Killifish;Libraries;Life;life history;Literature;male;Mammals;Meiosis;methylome;Mitotic;Modeling;Modification;neuronal cell body;next generation;offspring;Oryziinae;Outcome;Partner in relationship;Pattern;Phenotype;Predisposition;programs;promoter;Puberty;Publishing;pyrosequencing;Recording of previous events;Reproduction;reproductive;reproductive development;Reproductive Health;Research;Research Project Grants;Resistance;Risk;RNA;Role;sex;Sexual Maturation;Site;sperm cell;Spermatids;Spermatocytes;Spermatogenesis;Spermatogonia;Structure of primordial sex cell;subfertility;success;Testing;Time;Tissues;tool;trait;transcriptome;transmission process;Vertebrates;whole genome;young adult

PROJECT_TITLE: Germline transmission of epigenetic alterations to offspring

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: IRVINE

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative This application proposes to develop unique prostate cancer patient-derived organoids and cell resources for dissecting factors and mechanisms (i.e. GARP/TGF-β signaling) leading to immune differences between African American and European American prostate cancer. In addition, a novel strategy for enhancing immune checkpoint therapies in prostate cancer in general and African American prostate cancer in particular may be developed by repurposing Dabigatran etexilate, an anticoagulant drug, through targeting GARP/TGF-β signaling.

PI_NAMEs: AGRAWAL, ANSHU ;ZI, XIAOLIN  (contact)

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: Accounting;Affect;African American;Age;American;androgen independent prostate cancer;anti-CTLA4;anti-PD-1;Anticoagulants;Aspirin;Atrial Fibrillation;Autologous;Autologous Tumor Cell;Benign;Biological Factors;cancer health disparity;Cancer Patient;Cancer Vaccines;Carcinoma;CD8-Positive T-Lymphocytes;Cells;checkpoint therapy;Clinical Trials;clinically relevant;Coculture Techniques;Complex;Cryopreservation;cytotoxic CD8 T cells;Data;Death Rate;Development;Disparity;Dissection;Distant;Docking;effector T cell;Enzyme-Linked Immunosorbent Assay;ERG gene;Ethnic Origin;Ethnic Population;European;Fibroblasts;Flow Cytometry;Formalin;Gene Fusion;Genetic;Gleason Grade for Prostate Cancer;Goals;health disparity;Histology;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immune Tolerance;Immunobiology;Immunohistochemistry;Immunologics;Immunosuppression;Immunotherapy;improved outcome;Incidence;individual patient;Infiltration;Integrins;Interferons;LRRC32 gene;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mediating;men;Modeling;mouse model;Mutation;neoplastic cell;novel strategies;Organoids;overexpression;Paraffin Embedding;Patients;Peripheral Blood Lymphocyte;Persons;Plasma;Play;prostate cancer progression;Prostatic Neoplasms;Provenge;PTEN gene;Race;receptor;Regulatory T-Lymphocyte;Reporting;Resistance;Resources;response;Role;Safety;side effect;Signal Transduction;Socioeconomic Factors;Stains;Stroke prevention;T cell response;T-Lymphocyte;Testing;TGFB1 gene;Tissue Embedding;Tissues;tool;Transforming Growth Factor beta;Transgenic Organisms;tumor;Tumor Escape;tumor growth;tumor microenvironment;tumor xenograft;Tumor-Derived;Variant

PROJECT_TITLE: Ethnicity-determined T cell responses and GARP/TGFbeta1 signaling in prostate cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Hearing Loss;Human Genome;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE 1 in 1000 children are born with some form of inherited hearing loss. We have identified gene, Foxi3, that is activated very early in the development of the ear and causes a severe disruption of the inner ear, middle ear and external ear when mutated. We believe that understanding the function of this gene may help to shed light on the causes of human birth defects.

PI_NAMEs: GROVES, ANDREW K (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Affect;Alleles;ATAC-seq;Auditory;Binding;Biochemical;Bioinformatics;Branchial arch structure;Cell Death;Cell Differentiation process;Cell model;Cells;Central Nervous System;Cephalic;Chick;Chick Embryo;Child;ChIP-seq;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Conductive hearing loss;Congenital Abnormality;craniofacial;critical period;Data;deep sequencing;Defect;Development;Ear;ear development;Ear ossicles;Ectoderm;Embryo;Embryonic Development;embryonic stem cell;Endoderm;Epidermis;Epigenetic Process;ES Cell Line;experimental study;External Ear;Failure;Family;FGF8 gene;forkhead protein;Funding;gain of function;gastrulation;Gene Expression;Gene Expression Profile;gene function;gene repression;Genes;Genetic;Genetic Transcription;genetic variant;genomic locus;Goals;Head;Hearing;hereditary hearing loss;Homeobox Genes;Hour;Human;Immunoprecipitation;inner ear development;interest;Knock-in Mouse;Knockout Mice;Labyrinth;loss of function;Maps;Mesenchyme;microtia;middle ear;Modeling;Molecular;Molecular Analysis;mouse model;Mus;Mutagenesis;mutant;Mutant Strains Mice;Mutate;Mutation;Neural Crest;Neural Crest Cell;neural plate;novel;Nuclear Localization Signal;Otic Placodes;overexpression;Pathogenicity;Patients;Pattern;Phenotype;progenitor;Regulation;Repression;response;Role;Sensorineural Hearing Loss;Series;Signal Induction;Signal Transduction;single-cell RNA sequencing;Structure;Switzerland;Testing;Time;Tissues;transcription factor;Transcription Initiation;Up-Regulation;Variant;Work

PROJECT_TITLE: Genetic Regulation of Inner, Middle and Outer Ear Development

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Physical Activity;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Understanding the role of the LDL receptor related protein (LRP1) and lysyl oxidase (LOX) in aneurysm formation could provide important insights for the management and prevention of aortic aneurysms. This project seeks to investigate how these pathways regulate the development and maintenance of the vasculature and how aerobic exercise modulates these processes. The Aims of the proposal utilize both mouse models of aortopathy and human subjects to address these questions.

PI_NAMEs: UCUZIAN, ARECK A (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: abdominal aorta;Abdominal Aortic Aneurysm;Acute;Address;Aerobic Exercise;age group;Aldehydes;Aminopropionitrile;Aneurysm;Animal Model;Aorta;Aortic Aneurysm;Aortic Diseases;ascending aorta;Attenuated;Baltimore;Biology;Biomechanics;Blood Pressure;Blood Vessels;Cessation of life;Chest;Chronic;Collagen;Copper;Country;crosslink;Data;Deposition;Development;Disease;Disease Progression;Dissection;Doctor of Philosophy;Drug usage;Elasticity;Elastin;Enzymes;Event;Exercise;exercise intervention;experience;extracellular;Extracellular Matrix;Focal Adhesions;Foundations;Gene Mutation;Genes;Genetic;Genetic Determinism;Goals;Heart Rate;Homeostasis;Human;human subject;improved;Inflammatory;Inflammatory Infiltrate;insight;Knowledge;LDL-Receptor Related Protein 1;LDL-Receptor Related Proteins;Lysine;Maintenance;Marfan Syndrome;Maryland;Mediating;Mentorship;Modeling;Molecular;mouse model;Mus;Muscle Contraction;novel;Pathogenesis;Pathway interactions;Patients;Peptide Hydrolases;Physicians;pilot trial;prevent;Prevention;Process;protective factors;Protein-Lysine 6-Oxidase;Proteins;Proteomics;Pulse Pressure;Regulation;Research Personnel;Role;Scientist;Severities;shear stress;Signal Pathway;Signal Transduction;skills;Smooth Muscle Myocytes;Study Subject;Thoracic Aortic Aneurysm;Tissues;Transforming Growth Factor beta;treadmill;United States;Universities;Vascular Diseases;Vascular Smooth Muscle

PROJECT_TITLE: Mechanisms of aortopathy in LRP1 deficiency

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence;Rare Diseases

ORG_CITY: HANOVER

ORG_DEPT: CHEMISTRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative: Bacterial pathogens adapt their strategies by sensing and adapting to signals from the environment within the human host. This study will reveal the molecular characteristics of those signals and the mechanisms of pathogen adaptation and response.

PI_NAMEs: KULL, FREDRICK JON (contact);MUNSON, GEORGE PATRICK

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acinetobacter;Address;alpha helix;Arabinose;Artificial Intelligence;Belief;Binding;Biochemistry;biological adaptation to stress;Biological Models;Categories;Characteristics;Citrobacter rodentium;Collaborations;combat;dimer;Dimerization;DNA;DNA Binding;DNA Binding Domain;Enteral;enteric pathogen;enteroaggregative Escherichia coli;enterotoxigenic Escherichia coli;Environment;Escherichia;Family;Family member;Family suidae;Fatty Acids;Gene Expression;Gene Expression Regulation;Genetic study;Genetic Transcription;Goals;Homologous Gene;Human;human morbidity;human mortality;inhibitor;innovation;Klebsiella;Knowledge;Legionella;Ligand Binding;Ligand Binding Domain;Ligands;long chain fatty acid;Machine Learning;Mediating;member;Metabolism;Microbiology;Molecular;Molecular Conformation;Morbidity - disease rate;mortality;multidisciplinary;novel;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;polypeptide;Positioning Attribute;Protein Family;protein function;Proteins;Pseudomonas;Publishing;Regulator Genes;Regulon;Research;Resolution;response;Role;Salmonella;Salmonella enterica;Shigella;Signal Transduction;small molecule;Specificity;structural biology;Structure;Testing;Therapeutic;trait;transcription factor;Vibrio;Vibrio cholerae;Virulence;virulence gene;Work;Yersinia

PROJECT_TITLE: Virulence gene regulators of enteric bacterial pathogens: Determining the structural and functional mechanisms of small molecule and polypeptide inhibitors

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: LUBBOCK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

PHR: Narrative Coronary heart disease (CHD) remains a major cause of morbidity and mortality in american population. Studies proposed in this application will investigate the novel mechanism of myocardial infarction and using a transgenic mice model with higher or deleted expression of thioredoxin. If successful, thioredoxin or its derivatives could be developed as new therapeutic molecule for treatment of heart failure.

PI_NAMEs: DAS, KUMUDA C (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Acute;Adenine;Affect;American;Apoptosis;Autophagocytosis;Blood flow;Blood Vessels;Cardiovascular Diseases;Cells;Cessation of life;Clinical Management;Clinical Trials;Coronary;Coronary artery;coronary artery occlusion;Coronary heart disease;coronary perfusion;Data;Degradation Pathway;Development;effective intervention;Endothelial Cells;Enzymes;Event;experience;Generations;Heart;Heart failure;Heart Injuries;Human;Hypoxia;Impairment;improved;in vivo;Infarction;inhibition of autophagy;inhibitor;Injury;insight;Intervention;Ischemia;Knockout Mice;Lysosomes;Mediating;MG132;Microcirculation;Molecular Chaperones;Morbidity - disease rate;mortality;mouse model;Mouse Strains;multicatalytic endopeptidase complex;Mus;Muscle Cells;mutant;Myocardial;Myocardial Infarction;Myocardial perfusion;Myocardial Reperfusion Injury;Myocardial tissue;Myocardium;Necrosis;Nitric Oxide;Nitric Oxide Synthase;NOS3 gene;novel;novel therapeutics;Nutrient;oxidation;Oxidoreductase;oxygen transport;Oxygenases;Pathway interactions;Patients;Perfusion;Play;Population;Production;Prognostic Factor;Proteins;Reaction;Reactive Nitrogen Species;Relaxation;Reperfusion Injury;Reperfusion Therapy;Research;Role;Signal Transduction;Superoxides;Testing;tetrahydrobiopterin;Time;Transfection;Transgenic Mice;Transgenic Organisms;translational model;TXN gene;United States;Vascular Diseases;Vascular Endothelium

PROJECT_TITLE: Vascular dysfunction in coronary microcirculation

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Heart failure is a complex disease characterized by the inability of the heart to pump an adequate supply of blood to the body and is often driven by mitochondrial dysfunction. Current therapies for heart failure are limited and aim to alleviate the symptoms of the disease rather than correct the underlying causes. The goals of our proposed studies are to elucidate novel mechanisms to enhance mitochondrial function in the heart in order to normalize myocardial energetics and restore cardiac pump function in heart failure.

PI_NAMEs: MAKAREWICH, CATHERINE A (contact)

PROJECT_TERMS: Affect;Binding;Bioenergetics;Biological Assay;Biology;Calcium;candidate identification;Carbohydrates;Cardiac;Cardiac health;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;Cell Respiration;Clinical;Code;Complex;Computer Analysis;Data;Disease;disease model;Electron Transport;Electron Transport Complex III;Equilibrium;Etiology;Event;experimental analysis;Experimental Models;fatty acid oxidation;Fractionation;gain of function;Gene Deletion;Generations;Genes;Glucose;glucose metabolism;Goals;Heart;Heart Diseases;Heart failure;heart function;heart metabolism;Heart Mitochondria;Homeostasis;Impairment;in vitro Assay;in vivo;Inner mitochondrial membrane;insight;Knockout Mice;Link;link protein;long chain fatty acid;loss of function;mammalian genome;Measures;Membrane;Metabolic;Metabolism;Methods;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Molecular;Molecular Mechanisms of Action;mouse model;Multiprotein Complexes;Mus;Muscle Cells;Myocardial;Myocardial Ischemia;Names;Neonatal;novel;novel strategies;Open Reading Frames;Outcome;Output;overexpression;oxidation;Oxidation-Reduction;Peptides;Performance;Physiological;Play;pressure;Process;protein complex;Protein Import;Proteins;Pump;Rattus;recruit;reduce symptoms;Regulation;Research;Respiration;respiratory;response;Role;Series;Signal Transduction;small hairpin RNA;Stress;symptom treatment;Syndrome;Testing;Therapeutic;therapeutic target;Transgenic Mice;Translational Repression;Vascular blood supply;Ventricular;Virus

PROJECT_TITLE: Microprotein Regulation of Mitochondrial Function

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative: This work will support the popular FreeSurfer neuroimaging analysis software program used by thousands of researchers world-wide. FreeSurfer uses cutting edge algorithms to automatically extract a host of biomarkers from brain imaging data which can be used for research, pharmaceutical evaluation, and diagnosis. This proposal will allow for continued support of FreeSurfer from the developers as well as new development to make FreeSurfer faster, more robust, and easier to interpret.

PI_NAMEs: FISCHL, BRUCE ;GREVE, DOUGLAS NOWLIN (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Adolescent;Algorithms;Alzheimer's Disease;Anatomy;Atlases;Bayesian Modeling;biobank;Biological Markers;Blood Vessels;bone;Brain;Brain imaging;Cell Nucleus;Cerebrum;cognitive development;Computer software;connectome;cranium;Data;data acquisition;deep learning;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;Documentation;Educational process of instructing;Electroencephalography;Engineering;Evaluation;Fatty acid glycerol esters;Framingham Heart Study;Free Will;Functional Magnetic Resonance Imaging;Funding;generative models;Grant;Growth;Hippocampus;Human;human imaging;Image;Individual;Industrialization;Inherited;innovation;large scale data;Lesion;Leukoaraiosis;Machine Learning;Magnetic Resonance Imaging;Maintenance;Manuscripts;Modality;Modeling;Morphologic artifacts;multimodality;Multiple Sclerosis Lesions;neuroimaging;Neurosciences;Operating Rooms;Optics;Output;Pharmacologic Substance;Positron-Emission Tomography;Probability;programs;Publications;Research;Research Personnel;Series;Software Engineering;Stream;Structure;success;Surface;synergism;System;Testing;Thalamic Nuclei;tool;United States National Institutes of Health;Vision;white matter;Work

PROJECT_TITLE: FreeSurfer Development, Maintenance, and Hardening

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project narrative Seasonal influenza remains a serious health threat each year for older Americans despite annual vaccination, particularly those over age 75. We leverage our ongoing, well characterized longitudinal cohort study of influenza vaccination in older adults >75 to investigate immune signatures for vaccine effectiveness and the impact of key host and vaccine factors over time. This project has broad clinical and research implications in immunity and health of older Americans.

PI_NAMEs: LENG, SEAN XIAO (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Address;Affect;Age;age related decline;Aging;American;anti-influenza;Antibodies;Antibody titer measurement;Biological;Blood specimen;breakthrough infection;Cause of Death;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Circulation;Clinical;cohort;Cohort Studies;Collection;Communities;comorbidity;Convalescence;Coupled;cross reactivity;cytokine;Data;Development;Disease;Elderly;Elements;Environmental Exposure;Environmental Risk Factor;Flow Cytometry;flu;Foundations;frailty;functional status;Geriatrics;Health;Hemagglutination;high dimensionality;Immune;immune function;Immune response;Immune system;Immunity;immunological status;Immunologics;Immunology;immunosenescence;Infection;infection risk;Inflammaging;Inflammation Mediators;Influentials;Influenza;influenza infection;Influenza vaccination;Infrastructure;inhibiting antibody;Integration Host Factors;Kinetics;Laboratories;Longitudinal cohort;Longitudinal cohort study;Longitudinal Studies;Molecular;Molecular Virology;Monitor;multiple chronic conditions;older adult;Peripheral Blood Mononuclear Cell;Persons;Phage Display;Plasma;Population;predicting response;predictive signature;Principal Investigator;programs;Public Health;Recommendation;repository;Research;response;Risk;sample collection;Sampling;seasonal influenza;Seasons;senescence;Serology;Serum;single cell sequencing;single-cell RNA sequencing;Specimen;Subjects Selections;T cell receptor repertoire sequencing;T-Lymphocyte;Technology;Time;tool;transcriptome sequencing;universal vaccine;Vaccination;vaccination strategy;vaccine effectiveness;vaccine response;Vaccines;Variant;Virus

PROJECT_TITLE: Leveraging an ongoing longitudinal study of influenza vaccination to define immune signatures of response and risk of infection in older adults >75


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Tuberculosis

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The UCSD Collaborative Clinical Trials Unit (CTU) brings together seven dynamic Clinical Research Sites in the U.S., sub-Saharan Africa, and India, with a proven track record of significant research into the pathogenesis, treatment and prevention of HIV and its related complications and coinfections. Our proposed CTU has the expertise, experience, infrastructure, and access to geographically, racially and ethnically diverse participant populations living with or at risk for HIV to make valuable contributions to the research priorities of the NIAID clinical trials networks.

PI_NAMEs: BENSON, CONSTANCE ANN (contact)

PROGRAM_OFFICER_NAME: MEANS, DAVID MICHAEL

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Administrative Efficiency;Adult;Affect;Africa South of the Sahara;African;African American;AIDS prevention;Anti-Retroviral Agents;Area;Black race;California;Chronic;clinical center;clinical research site;Clinical Treatment;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Clinical Trials Unit;co-infection;Collaborations;Colorado;Communication;Communities;community advisory board;community engagement;Community Networks;community partners;comorbidity;Complex;Disease;drug action;Drug Formulations;Drug resistance in tuberculosis;Education;Enrollment;Epidemic;ethnic diversity;Evaluation;experience;Formulation;Geographic Distribution;Geographic Locations;Geography;Goals;Hepatitis B;high risk;Hispanic;HIV;HIV Infections;HIV prevention trials network;HIV/AIDS;HIV/TB;Hospitals;Hot Spot;India;Inflammation;Infrastructure;innovation;International;Latinx;Leadership;Los Angeles;Mentors;Metabolic;Molecular Epidemiology;National Institute of Allergy and Infectious Disease;neutralizing antibody;novel;Organ;outreach;Participant;Pathogenesis;Performance;Persons;Pharmaceutical Preparations;Population;Populations at Risk;pre-exposure prophylaxis;prevent;Prevention;Preventive vaccine;Productivity;racial diversity;recruit;Research;Research Infrastructure;Research Personnel;Research Priority;Resources;Risk;Shapes;Social Behavior;South Africa;South Asian;Sum;synergism;Talents;Technology;Therapeutic;Therapeutic Clinical Trial;transmission process;trial planning;Tuberculosis;Universities;Viral;working group

PROJECT_TITLE: UCSD Collaborative Clinical Trials Unit


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Maternal Health;Mental Health;Pregnancy;Prevention;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Pre-Exposure prophylaxis (PrEP) represents an opportunity to dramatically reduce the elevated risk of HIV in pregnant and breastfeeding women in sub-Saharan Africa, but shared decision-making about its use is essential to identify appropriate users and promote adherent use. The proposed study aims to develop and pilot test a PrEP shared decision-making aid for pregnant women in Zambia to determine if use of the aid effectively promotes personally appropriate decisions about PrEP use, and to understand if and how its use may serve to promote adherence among PrEP adopters. This aid will be designed according to the relevant values and decision-making needs of pregnant women, their male partners, and antenatal health care workers.

PI_NAMEs: HILL, LAUREN  (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Adherence;Africa South of the Sahara;AIDS prevention;antenatal;antenatal care;Award;Behavior Therapy;Behavioral Research;Breast Feeding;career;career development;Clinical;Cognitive;Complement;Conflict (Psychology);Counseling;Country;Data;Decision Making;design;Development;Doctor of Philosophy;Effectiveness;effectiveness trial;emtricitabine;Ensure;Evaluation;experience;Foundations;Future;Goals;Guidelines;Health Personnel;HIV;HIV Infections;HIV risk;Horizontal Disease Transmission;improved;Individual;Infection;Intervention;Knowledge;Life Style;male;Medical;medication compliance;Medicine;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Modeling;Modification;Mother-to-child HIV transmission;Motivation;Needs Assessment;novel;Nurses;Oral;Participant;patient oriented;Patients;Perception;person centered;Pharmaceutical Preparations;pill;Pilot Projects;pilot test;pilot trial;Plasma;Postpartum Period;pre-exposure prophylaxis;preference;Pregnancy;pregnant;Pregnant Women;prevent;Prevention;Primary Prevention;Process;Productivity;Protective Agents;Provider;Randomized;Recommendation;Research;Research Personnel;Risk;Role;Scientist;Self Efficacy;Services;sex;shared decision making;skills;standard of care;Tenofovir;Testing;theories;therapy design;tool;Training;training opportunity;Training Programs;treatment effect;Vagina;Vertical Transmission;Woman;Zambia

PROJECT_TITLE: Promoting PrEP shared decision-making and adherence among pregnant and breastfeeding women in Zambia

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Hematology;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative In the absence of IL-27, mice infected with the parasite Toxoplasma gondii develop a lethal, T cell-mediated inflammatory response, but the basis for their sepsis-like reaction is poorly understood. Our studies indicate that this immune pathology is characterized by enhanced monocyte responses and the overproduction of GM- CSF. The aim of this proposal, then, is to understand how IL-27 regulates monocyte responses and protects from pathology, and the information gained from this work will further our understanding of cytokine regulatory circuits and how these can be targeted for human health.

PI_NAMEs: ALDRIDGE, DANIEL  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: acute infection;Affect;Automobile Driving;Bone Marrow;CD4 Positive T Lymphocytes;cell mediated immune response;cell type;Cells;Cellular Immunity;cellular targeting;Clinical;Coagulation Process;Colony-Stimulating Factor Receptors;Competence;Complex;Cre lox recombination system;cytokine;cytokine release syndrome;Data;Data Analyses;Data Set;Development;Disease;Disseminated Intravascular Coagulation;Emergency Situation;Equilibrium;experimental study;Flow Cytometry;Gene Expression Profiling;genetic approach;Genetic Transcription;Granulocyte-Macrophage Colony-Stimulating Factor;Granulocyte-Macrophage Colony-Stimulating Factor Receptors;Health;hematopoietic stem cell differentiation;Hematopoietic stem cells;Hemophagocytic Lymphohistiocytoses;high dimensionality;Human;Hyperactivity;Immune;Immune response;immunopathology;immunothrombosis;In Vitro;in vivo;in vivo evaluation;Infection;Inflammatory;Inflammatory Response;Inflammatory Response Pathway;insight;Interferon Type II;Interleukin-6;Knowledge;Laboratory Study;Macrophage;Macrophage activation syndrome;Measures;Mediating;monocyte;Mus;Myelogenous;Parasites;pathogen;Pathologic;Pathology;Pathway interactions;Peripheral;Phenotype;Population;prevent;Process;Production;progenitor;Reaction;receptor;Resistance;Resistance to infection;response;restraint;Role;Sepsis;single-cell RNA sequencing;stem cells;System;T-Lymphocyte;Techniques;Testing;Thrombosis;Tissues;TNF gene;Toxoplasma gondii;Toxoplasmosis;Trauma;Work

PROJECT_TITLE: Impact of IL-27 on monocyte responses to Toxoplasma gondii infection


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: Chicago

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE To bolster their chances at survival in the infected host, viruses have evolved numerous strategies that subvert host antiviral immune functions. In this application, we will characterize the ORF8 protein, an important protein of the deadly human pathogen SARS-CoV-2 virus, that mediates unique functions in suppression of host immune pathways. Our study is significant for progress in understanding the unique biology of SARS-CoV-2, and for the development of new therapeutics.

PI_NAMEs: BOUVIER, MARLENE  (contact)

PROJECT_TERMS: 2019-nCoV;adaptive immune response;adaptive immunity;Address;Affect;Alleles;Antigen Presentation;antiviral immunity;Binding;Biological Assay;Biology;CD8-Positive T-Lymphocytes;Cell surface;Cells;Cellular Immunity;cellular transduction;Characteristics;clinically relevant;Code;Complex;Coronavirus;COVID-19;COVID-19 pathogenesis;COVID-19 treatment;Crystallization;current pandemic;Data;Development;Diagnosis;Disease;Down-Regulation;Endowment;Epitopes;Evaluation;exhaustion;experience;Flow Cytometry;Future;gel electrophoresis;Genomic Segment;Goals;Growth;Histocompatibility;Histocompatibility Antigens Class I;HLA-A gene;HLA-B Antigens;HLA-C Antigens;human pathogen;Immune;Immune Evasion;immune function;Impairment;In Vitro;in vivo;Innate Immune Response;innovation;interest;Interferon Type I;Investigation;Knowledge;Mediating;Molecular;Morbidity - disease rate;mortality;mutant;Mutation;Natural Immunity;Natural Killer Cells;NK Cell Activation;novel;novel therapeutics;Nuclear;Open Reading Frames;pandemic coronavirus;pandemic disease;pathogen;Pathogenesis;Pathologic;Pathway interactions;Patients;Phenotype;pressure;prevent;protein protein interaction;Proteins;Research;response;Role;SARS coronavirus;SARS-CoV-2 genome;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;Scheme;severe COVID-19;small molecule inhibitor;Specificity;Structure;Surface;System;T cell response;therapeutic development;Variant;Viral;Virulence;Virus;Virus Replication

PROJECT_TITLE: Immune evasion by SARS-CoV-2: the role of HLA class I

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

PHR: Project Narrative  Syphilis, caused by the bacterium Treponema pallidum, continues to play prominently as a sexually transmitted infection in the United States and worldwide. Given that the membrane lipoproteins of T. pallidum are recognized as being particularly vital to the biology of the spirochete, we are attempting to discern how the lipoproteins and their metabolic partners play prominently in T. pallidum’s complex parasitic strategy, with an emphasis on flavin utilization, thereby potentially revealing new strategies to thwart the infectious process in humans.

PI_NAMEs: HENDRIXSON, DAVID R (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TITLE: The flavin-centric metabolic lifestyle of Treponema pallidum


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE RNA modifications by adenosine-to-inosine (A-to-I) editing are highly enriched and tightly regulated in the human brain, and their dysregulation has been implicated in the neuropathology of Alzheimer’s disease (AD). This proposal represents a critical step towards identifying functionally important editing sites and hyper-edited genes involved in normal aging and AD etiology, including those that are dynamically regulated across brain regions, discrete cell types, and those that are genetically regulated. Results from this proposal will serve as a valuable resource to expand neuropathological and genetic underpinnings of AD, offering a springboard for more effective therapeutic targets for this devastating disease.

PI_NAMEs: BREEN, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Address;Adenosine;Affect;Affinity;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Apoptosis;Applied Genetics;Automobile Driving;base;Binding;Biological;Biological Process;Brain;brain cell;Brain region;causal variant;cell type;Cells;Central Nervous System;Clinical;Code;Cognitive;cohort;Complex;Computing Methodologies;Cytoplasm;Data;data resource;Dementia;design;Disease;disorder risk;Double-Stranded RNA;dsRNA adenosine deaminase;Elderly;Enzymes;Etiology;Functional disorder;Gene Expression;Genes;Genetic;Genetic Diseases;genetic information;genome wide association study;genome-wide;genomic data;Genomics;Genotype;Guanosine;Human;Individual;Inosine;Interferons;Knowledge;lens;Link;Maps;Masks;Methods;MicroRNAs;Modification;Molecular;Nerve Degeneration;neurobiological mechanism;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuroglia;Neurons;neuropathology;new therapeutic target;normal aging;Nuclear;Onset of illness;Outcome;Pathogenicity;Pattern;Population;posttranscriptional;Process;protein aminoacid sequence;Quantitative Trait Loci;Regulation;Research;Resources;risk variant;RNA;RNA Editing;RNA Sequences;RNA Splicing;RNA Stability;RNA-Binding Proteins;Role;Sampling;Severities;Severity of illness;Site;stress granule;Structure;success;therapeutic genome editing;therapeutic target;therapeutically effective;Tissues;tool;Transcript;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Translation Initiation;Translational Regulation;Translational Repression;Translations;Work

PROJECT_TITLE: Integrative genomic analysis of adenosine-to-inosine editing in Alzheimer's disease

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: The Seattle-Lausanne CTU has an overall goal to make rapid progress in the development of globally effective HIV and TB vaccines. In addition, we will seek improved therapies to successfully treat all persons living with HIV to prevent HIV disease and associated diseases, and in the long-term hope to achieve sustained viral remission without the need for treatment.

PI_NAMEs: MCELRATH, MARGARET JULIANA (contact)

PROGRAM_OFFICER_NAME: ROBY, GREGG A,

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Adult;Area;career;Cessation of life;Clinical;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Clinical Trials Support Unit;Clinical Trials Unit;Communication;Communities;community partners;comorbidity;Data;Decision Making;design;Development;Disease;Disease Management;Disease remission;Enrollment;Ensure;Environment;Epidemic;experience;first-in-human;Fostering;Fred Hutchinson Cancer Research Center;Funding;Future;Goals;HIV;HIV Infections;HIV vaccine;HIV Vaccine Trials Network;Immune;immunoprophylaxis;Immunotherapy;improved;Infrastructure;innovation;insight;Institution;International;Leadership;Link;member;Mentorship;Morbidity - disease rate;National Institute of Allergy and Infectious Disease;neutralizing antibody;next generation;novel;novel therapeutics;operation;pandemic disease;Persons;Pharmacy facility;Phase;Physicians;Population;prevent;Preventive vaccine;Process;Productivity;Regimen;Research;Research Activity;Research Personnel;Research Priority;research study;Resource Allocation;Resources;response;Scientist;Seasons;Site;skills;Structure;Target Populations;Therapeutic;Therapeutic Clinical Trial;Tuberculosis;Tuberculosis Vaccines;Universities;vaccine candidate;vaccine immunotherapy;vaccine trial;Vaccines;Viral;Vision;volunteer;Washington

PROJECT_TITLE: Seattle-Lausanne Clinical Trials Unit


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Serious Mental Illness;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative: Cognitive impairment and brain abnormalities are common and persist after depression remission in those with LLD, compounding dementia risk in both individuals with acute and remitted LLD. In this K23 application, we will examine systemic neural and cognitive benefits of aerobic exercise training in older adults with remitted LLD. This will generate preliminary data regarding neural targets of aerobic exercise training that may translate to cognitive benefits in those with rLLD, a population who remains at high risk for dementia despite successful treatment of depression.

PI_NAMEs: GUJRAL, SWATHI  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acute;Aerobic Exercise;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;analytical method;Area;Attenuated;Award;behavioral health;Biological;Brain;brain abnormalities;brain health;Brain Pathology;Brain region;burden of illness;Clinical;clinical translation;Cognition;Cognitive;cognitive benefits;cognitive change;Cognitive deficits;cognitive enhancement;cognitive function;cognitive performance;cognitive process;Cognitive remediation;Data;Data Analytics;Dementia;dementia risk;depressive symptoms;Diagnosis;disability;Disease remission;Elderly;Exclusion;executive function;exercise intervention;exercise training;experience;Future;geriatric depression;Goals;gray matter;Health;high risk;Hippocampus;Home;Impaired cognition;Impairment;improved;Individual;Intervention;Investigational Therapies;Knowledge;Laboratories;Late Effects;Learning;Life Style Modification;lifestyle factors;Literature;Medical;Memory;Mental Depression;Mental disorders;Methodology;mild cognitive impairment;Moods;mortality;multiple chronic conditions;National Institute of Mental Health;Nerve Degeneration;neural;neural circuit;neuroimaging;neuroimaging marker;neuromechanism;Neuropsychology;neurotoxic;non-demented;Nonpharmacologic Therapy;Occipital lobe;older adult;Outcome;Outcome Measure;Participant;Pharmacological Treatment;Pharmacotherapy;Physical activity;poor health outcome;Population;post intervention;Prefrontal Cortex;preservation;Prevalence;prevent;Process;Randomized;Randomized, Controlled Trials;Recording of previous events;Recovery;Research Personnel;Risk;social engagement;Supervision;Thalamic structure;Training;Translating;translational scientist;trial comparing;Vascular Dementia

PROJECT_TITLE: Aerobic Exercise for Optimizing Cognitive and Brain Health In Remitted Late-Life Depression

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative Alzheimer’s disease is the most common neurodegenerative disease, characterized by pathological deposits amyloid beta and hyperphosphorylated tau. Genetic and molecular studies have uncovered novel pathways implicated in disease risk; however, effective therapies to treat dementia have not yet been developed. The goal of the proposed study is to evaluate the impact of a putative therapeutic target gene on Alzheimer’s disease onset and progression in mice.

PI_NAMEs: SCHAFFER, ASHLEIGH E (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: AD transgenic mice;Age;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Attenuated;Basic Science;behavior test;Behavioral;Biochemical;Bioinformatics;Biological Markers;Brain;Brain Pathology;brain tissue;Caregivers;causal variant;Cause of Death;Childhood;Clinical;cognitive ability;cognitive function;Collaborations;comparison control;Complex;Cytoplasm;Data;Defect;Dementia;Deposition;design;Disease;Disease Progression;disorder risk;dosage;effective therapy;Elderly;Environmental Risk Factor;experience;Foundations;Functional disorder;Future;Genes;Genetic;genetic risk factor;Goals;Heterozygote;Histologic;Histology;Impaired cognition;improved;in vivo;Mediator;Messenger RNA;Molecular;Motor Neuron Disease;mouse model;Mus;Mutant Strains Mice;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;novel;Nuclear RNA;Onset of illness;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Persons;Phenotype;Phosphorylation;Phosphotransferases;preservation;Prior Therapy;protein expression;protein TDP-43;Proteins;Psyche structure;Research;Research Design;RNA;RNA Processing;RNA-Binding Proteins;Sampling;Senile Plaques;Series;Testing;therapeutic development;therapeutic target;Tissue Sample;transcriptomics;Transgenic Mice;Up-Regulation;Variant;Western Blotting;Work

PROJECT_TITLE: Reduced allelic dosage of CLP1 attenuates cognitive dysfunction and pathological burden in transgenic mouse models of Alzheimer’s disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The Pre-doctoral Training in Virology at Yale University supports the education and training of the next generation of virology research scientists. Graduates from this program go on to leading positions in academia, industry and government, where they contribute to finding new approaches to prevent and combat viral diseases.

PI_NAMEs: KUMAR, PRITI  (contact);MOTHES, WALTHER H

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: pre-doctoral;Training Programs;virology

PROJECT_TITLE: Predoctoral Training Program in Virology

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Endocrine Disruptors;Mental Health;Microbiome;Neurosciences;Pediatric

ORG_DEPT: OTHER BASIC SCIENCES

PHR: PROJECT NARRATIVE Triclosan is a nearly ubiquitous exposure that has been phased out in some but not all consumer products due to recognition of its potential deleterious effects, including adverse neurobehavioral development. The proposed research will clarify the potential for triclosan to impact adolescent neurobehavior and elucidate the role of the gut microbiome and its metabolites in this association. This work has the potential to identify modifiable determinants and health effects of the adolescent gut microbiome.

PI_NAMEs: LAUE, HANNAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Academic achievement;Address;Adolescence;Adolescent;Adolescent Behavior;Adult;Affect;Age;antimicrobial;Anxiety;Attention;Attention deficit hyperactivity disorder;Award;Behavior;Behavior assessment;behavioral health;behavioral outcome;Biological;Birth;boys;Brain;Chemical Exposure;Child;Childhood;cohort;Complement;consumer product;Data;Data Collection;Dehydroepiandrosterone Sulfate;Development;Disease;DNA;dysbiosis;Educational workshop;Endocrine Disruptors;Endocrinology;Environment;environmental chemical;Environmental Epidemiology;Environmental Impact;Environmental Risk Factor;Estradiol;Etiology;Exposure to;fecal microbiome;Feces;Female;Follicle Stimulating Hormone;Future;girls;Gonadal Steroid Hormones;Growth;gut bacteria;gut microbiome;gut microbiota;gut-brain axis;Health;Hormonal;Hormonal Change;Hormones;Human;Individual;Infant;informant;interest;Learning;Link;Literature;Luteinizing Hormone;Measurement;Measures;Mediating;Mediation;Mental Depression;Mental Health;Mentors;Mentorship;Metabolism;metabolome;metagenomic sequencing;Methods;Microbe;microbial community;microbiome;microbiome alteration;microbiome analysis;microbiome composition;Modeling;National Institute of Environmental Health Sciences;neurobehavior;neurobehavioral;novel;Outcome;Participant;Perinatal;Phase;Play;Predisposition;Pregnancy;Problem behavior;prospective;Puberty;Research;Research Personnel;Research Priority;response;Risk Factors;Role;Serum;sex;Shapes;skills;Social Functioning;stool sample;Strategic Planning;Structure;Symptoms;System;Testing;Testosterone;Therapeutic;Toxic effect;Toxic Environmental Substances;Training;Triclosan;urinary;Visit;Work

PROJECT_TITLE: Triclosan, pubertal hormones, and the gut microbiome: implications for neurobehavior


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Cardiovascular diseases are the leading cause of death worldwide, accounting for over 30% of all deaths. This project aims to clarify the genetic variation contributing to these diseases by exploring the role of copy number variants, a class of genetic variation that remains underexplored. New methods will be developed to identify copy number variants in existing genotyped cohorts, specific copy number variants influencing cardiovascular traits will be identified, and the underlying extent and sources of copy number variant burden in heritable traits will be assessed.

PI_NAMEs: HUJOEL, MARGAUX  (contact)

PROGRAM_OFFICER_NAME: PURKISER, KEVIN

PROJECT_TERMS: 1q21;Accounting;Affect;Algorithms;All of Us Research Program;Area;Base Pairing;Benign;biobank;Biological;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cessation of life;Characteristics;Chromosome 1;Chromosome Mapping;cohort;Complex;Computer software;congenital heart abnormality;Copy Number Polymorphism;Coronary Arteriosclerosis;Data;Databases;detection method;Disease;disease phenotype;drug development;drug discovery;Frequencies;Genes;Genetic;genetic architecture;Genetic Variation;Genome;genome sequencing;Genomic Segment;Genomics;Genotype;Goals;Grant;Haplotypes;Heart failure;Heritability;identity by descent;Individual;Inherited;Ischemic Stroke;Knowledge;Lipids;Maps;Measurement;member;Mendelian disorder;Methodology;Methods;novel;open source;Participant;Pathogenicity;Phenotype;Play;Population;precision medicine;Predisposition;prevent;programs;Research;Research Personnel;risk variant;Role;Running;Single Nucleotide Polymorphism;SNP genotyping;Source;Statistical Methods;Stretching;Testing;trait;United States;Variant;Veterans;whole genome

PROJECT_TITLE: Exploring the role of genomic copy number variation in cardiovascular disease risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-D(20)L]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Maternal and neonatal morbidity and mortality caused by preeclampsia is a significant global health burden with approximately 10 million pregnancies impacted resulting in nearly half a million fetal or neonatal lives lost each year. A novel relationship may exist between mitochondrial damage and endothelial dysfunction and subsequent development of preeclampsia. Our overall goal is to investigate the mechanism whereby placental hypoxia is responsible for release of ROS and inflammation secondary to mitochondrial DNA (mtDNA) and if there is altered FMD as a result of heightened mtDNA in vessels from placentas in those with preeclampsia.

PI_NAMEs: MCINTOSH, JENNIFER J (contact)

PROJECT_TERMS: Affect;antagonist;Antioxidants;Award;Biology;Blood flow;Blood Vessels;Cardiovascular Diseases;career development;Cells;Child;Circulation;Coagulation Process;cytokine;Data;Development;Development Plans;DNA Damage;endothelial dysfunction;Endothelium;Ensure;Environment;experience;fetal;Fetal Death;Gestational Age;global health;Goals;Human;Human Biology;Hypertension;hypoperfusion;Hypoxia;Impairment;implantation;Inflammation;Inflammatory;inflammatory milieu;Innate Immune System;Institution;International;Invaded;Ischemia;maternal morbidity;Maternal-fetal medicine;Mediating;medical schools;Mentors;Metabolic;Microcirculation;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Modeling;Molecular;mortality;Myography;myometrium;Neonatal;neonatal morbidity;Neonatal Mortality;next generation sequencing;novel;Oxidative Stress;pathophysiology of preeclampsia;Patients;Perfusion;Perinatal;Physicians;Placenta;Placental Biology;Placentation;Positioning Attribute;Pre-Eclampsia;Pregnancy;pregnancy disorder;Pregnant Women;prevent;professor;Reactive Oxygen Species;Research;Research Project Grants;Resources;Risk;Role;Sampling;Scientist;Secondary to;skills;Spiral Artery of the Endometrium;targeted treatment;Techniques;Testing;therapeutic development;Therapeutic Intervention;therapeutic target;Time;Tissues;Toll-like receptors;trophoblast;Vascular blood supply;Vascular Diseases;Vascular Endothelium;vascular injury;Vasodilator Agents;Vasomotor;Video Microscopy;Villous;Wisconsin

PROJECT_TITLE: Novel role for placental endothelial mitochondria in preeclampsia


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Prevention;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE As many as 50,000 unnecessary thyroidectomies are performed in the United States each year because thyroid nodules are deemed indeterminate preoperatively when they are indeed benign. We have developed a new molecular test based on assessing DNA methylation in thyroid nodules that is accurate in preliminary tests and must be tested in the proposed clinical trial.

PI_NAMEs: HAHN, MARIA  (contact);YIM, JOHN H

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Affect;aspirate;Benign;Bilateral;Biological;Biological Assay;Biological Markers;Calcium;Cancer Diagnostics;cancer risk;Cellular Morphology;Classification;Clinical;clinical decision-making;Clinical Management;Clinical Trials;Cytopathology;Data;Decision Making;Development;Diagnostic;diagnostic accuracy;Diagnostic Procedure;Diagnostic Specificity;diagnostic strategy;diagnostic value;DNA Methylation;epigenetic marker;Epigenetic Process;epigenomics;Evaluation;Excision;Failure;Fine needle aspiration biopsy;Gene Expression;Gene Fusion;Gene Mutation;genome-wide;improved;inter-institutional;internal control;Knowledge;Laboratories;Malignant - descriptor;Malignant neoplasm of thyroid;Malignant Neoplasms;Medical center;methylation pattern;Molecular;molecular diagnostics;Morbidity - disease rate;Mutation;Nodule;Operative Surgical Procedures;Papillary thyroid carcinoma;Parathyroid gland;Pathologic;Patients;Performance;Physicians;Pilot Projects;pilot trial;Predictive Value;prospective;Prospective cohort;Publishing;Recurrent Laryngeal Nerve;Reproducibility;Sensitivity and Specificity;Specialist;Specimen;Surgeon;Testing;Thyroid Gland;Thyroid Hormones;Thyroid Nodule;Thyroidectomy;Tissues;Tracheostomy procedure;ultrasound;United States;Validation;Vocal Cord Paralysis

PROJECT_TITLE: Validation of epigenomic biomarkers for thyroid cancer diagnostics

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Any brain function, from smelling a rose to creating the memory of a rose’s smell, and from instructing my fingers to type these words to reading them and understanding their meaning, requires the assembly of an elaborate network of neuronal connections that generate functional neural circuits. Thus, understanding the mechanisms that transform neuronal identities into precise and stereotypic connections is essential for deciphering brain functions and generating therapies for brain disorders. Here, we uncover a novel molecular mechanism by which neurons “realize” their identity and generate stereotypic connections, opening new directions in the therapy of neurodevelopmental disorders and neurodegeneration.

PI_NAMEs: LOMVARDAS, STAVROS  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Affect;Alleles;Amino Acid Sequence;Amino Acid Substitution;Anterior;Astronomy;Axon;axon guidance;Bar Codes;Binding;Biochemical;Brain;brain disorder therapy;Cell Adhesion;Chemical Structure;Chemicals;ChIP-seq;Cilia;Code;Cognition Disorders;Computational algorithm;Computer Analysis;Data;design;endoplasmic reticulum stress;Experimental Designs;experimental study;extracellular;fascinate;Fingers;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;Genomics;insight;Maps;Mediating;Memory;Memory Disorders;Molecular;Nerve Degeneration;neural circuit;Neurodevelopmental Disorder;neuronal patterning;Neurons;Neuropil;novel;Odorant Receptors;Odors;olfactory bulb;Olfactory Epithelium;Olfactory Pathways;olfactory receptor;olfactory sensory neurons;Output;Pathway interactions;Phase;Play;Process;programs;Reading;receptor expression;Receptor Gene;Regulation;Reporter;Role;Seminal;Series;Signal Transduction;single-cell RNA sequencing;Smell Perception;Specificity;Stereotyping;Stress;Structure;Synapses;transcription factor;Transcriptional Regulation;Translating;transmission process;Volatilization;Work

PROJECT_TITLE: Converting stochastic olfactory receptor expression to stereotypic axon guidance programs


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative The olfactory system utilizes a family of receptors to recognize odors that are closely related to the receptors used for neurotransmission and hormonal regulation in the brain and other bodily systems. Understanding how the olfactory receptors detect and discriminate between a vast number of small organic molecules, many of which are similar to drugs in their chemical structure and physical characteristics, will allow us to adopt better strategies for drug development, including better control of side effects, greater efficacy and less tolerance development.

PI_NAMEs: FIRESTEIN, STUART J (contact)

PROJECT_TERMS: Acetates;Acetophenones;Adopted;Afferent Neurons;Agonist;Allosteric Site;antagonist;Area;Behavioral;Binding;Biological;Body System;Brain;Calcium;Cells;Characteristics;Chemical Structure;Chemicals;Chemistry;citral;Classification;Code;Collection;Complex;Data;Development;Discrimination;Dissociation;drug development;Drug Industry;Epithelium;Event;experimental study;Family;Funding;G-Protein-Coupled Receptors;Grant;grasp;high throughput screening;hormone regulation;Human;Image;In Situ;Individual;insight;Investigation;Lead;Light;Medical;Microscopic;Microscopy;Molecular;Monitor;Nature;Neurons;neurotransmission;novel;Odors;Olfactory Pathways;olfactory receptor;olfactory stimulus;Optics;Organic Chemistry;patch clamp;Pattern;Perception;Peripheral;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;programs;Psychophysics;receptor;receptor function;Receptor Inhibition;Resolution;response;Sensory;Sensory Receptors;sensory system;side effect;signal processing;Signal Transduction;Smell Perception;Sorting;Stimulus;Structure;Techniques;Testing;Tissues;virtual;Visualization;Work

PROJECT_TITLE: The perception of odor blends and mixtures: Modulation, Inhibition and Enhancement of Olfactory Receptors alters perception of complex blends

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Narrative Development of hearing in human begins embryonically and continues throughout the first few years of life, but how the sensory cells of the inner ear develop proper connections with the brain is poorly understood. We seek to understand how functional development of inner ear sensory cells leads to formation of synapses, maturation of neurons and transmission of sound information. This information may facilitate restoration of hearing in patients with genetic hearing loss.

PI_NAMEs: GELEOC, GWENAELLE S (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Action Potentials;Address;Affect;Afferent Neurons;Auditory;Auditory system;Birth;Brain;Calcium;Cell Maturation;Cell Physiology;Cell Survival;Cells;cellular transduction;Closure by clamp;Cochlea;deafness;Development;Discrimination;Electrodes;Electrophysiology (science);Embryo;Event;Exhibits;Exocytosis;Fiber;Fire - disasters;gene therapy;Genes;Glutamates;Hair;Hair Cells;Hearing;hearing restoration;hereditary hearing loss;high resolution imaging;Human;Image;Impairment;inner ear development;Inner Hair Cells;Labyrinth;Life;Maintenance;Mechanics;Mediating;Modeling;Morphology;mouse model;Mus;Mutant Strains Mice;Neonatal;neuronal patterning;Neurons;neurotransmission;novel therapeutics;Organ;Organ of Corti;Outcome;Outer Hair Cells;Patients;Pattern;postnatal;postsynaptic;Potassium;presynaptic;Process;Property;receptor;Recovery;restoration;ribbon synapse;RNA;Sampling;Sensory;Signal Transduction;single-cell RNA sequencing;sound;Specific qualifier value;speech in noise;spiral ganglion;superresolution microscopy;Synapses;Synaptic Transmission;synaptogenesis;Technology;Thinness;Tinnitus;Transcript;Transduction Gene;transmission process;Vesicle;Vestibular dysfunction;Vestibular Hair Cells;voltage;Wild Type Mouse;Work

PROJECT_TITLE: Functional development of hair cells and neurons in the inner ear


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative This project aims to transform the study of protein-protein interaction networks, which is the foundation of all biological signaling. By developing a technology for the rapid, inexpensive, and efficacious evolution of protein- protein interaction inhibitors, testing of potential therapeutic protein-protein interaction targets can become routine. This new evolution-based technology will have broad applications in basic cell biology and the study of biological signaling and will open new therapeutic opportunities.

PI_NAMEs: STYLES, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Academia;Acceleration;Adopted;Adoption;Affinity;Antibodies;Area;Bacteriophages;Basic Science;Biological;Biological Assay;Biological Models;Biology;Biosensor;c-myc Genes;Cancer cell line;career;career development;Cellular biology;Clinical;clinical development;cost;Data;design;Development;Diagnostic;Directed Molecular Evolution;Disease;DNA-Directed RNA Polymerase;drug development;drug discovery;Endowment;Ensure;Evolution;experience;fitness;Foundations;Frustration;Future;Generations;Genetic;Genetic Transcription;Goals;Immune Evasion;Immune system;inhibitor;innovation;KRAS2 gene;Laboratories;Lead;Libraries;Link;Maintenance;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;MDM2 gene;Medicine;member;Mentors;Mentorship;Methods;Molecular;Molecular Probes;notch protein;novel;novel therapeutics;Oncogenic;Output;Peptide Library;Play;Postdoctoral Fellow;prevent;Process;professor;programs;Property;protein protein interaction;Proteins;Protocols documentation;RAF1 gene;Research;Research Personnel;Signal Transduction;skills;small molecule;success;synthetic biology;System;Techniques;Technology;Testing;theories;Therapeutic;therapeutic protein;therapeutic target;Time;tool;TP53 gene;Training;Translating;Translational Research;Validation;Variant;Work

PROJECT_TITLE: Development of evolutionary technologies to reprogram protein-protein interactions


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Patient Safety;Pediatric;Pediatric - AIDS;Rare Diseases;Tuberculosis;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: NARRATIVE The Laboratory Center will provide laboratory-based scientific leadership, consultation and laboratory capacity, to enhance IMPAACT's Research Agenda and achieve its Scientific Aims. It will also provide the technical, regulatory and administrative infrastructure and oversight for all laboratory testing done in support of IMPAACT clinical trials.

PI_NAMEs: ALDROVANDI, GRACE M (contact)

PROGRAM_OFFICER_NAME: CLELAND, NAANA G

PROJECT_TERMS: Address;Adolescent;Affect;Anti-Retroviral Agents;Anti-retroviral drug resistance;antiretroviral therapy;Area;assay development;Biological Assay;Blood Volume;Caring;Child;Childhood;Clinical;clinical care;Clinical Trials;Clinical Trials Network;co-infection;Collaborations;comorbidity;Consultations;Data Coordinating Center;design;Development;Diagnosis;Disease remission;Ensure;Epidemic;Evaluation;Formulation;Genetic;Goals;Guidelines;high standard;HIV;HIV/TB;Immune response;improved;Infant;Infrastructure;innovation;interest;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Interruption;Intervention;Knowledge;Label;Laboratories;laboratory experience;laboratory experiment;Laboratory Research;Laboratory Study;Leadership;Licensure;Measurement;Methodology;Monitor;Multi-Drug Resistance;novel;novel strategies;operation;Pathogenesis;Pharmacology;Populations at Risk;Pregnant Women;Prevention;programs;reconstruction;Reproducibility;Research;Research Personnel;Research Priority;Resource-limited setting;Specimen;stem;study population;success;Technology;Testing;Therapeutic Clinical Trial;Total Quality Management;Training and Education;Training Programs;transmission process;Tuberculosis;United States National Institutes of Health;Vertical Disease Transmission;Viral Load result;Vision;Vulnerable Populations;Work

PROJECT_TITLE: International Maternal, Adolescent and Pediatric Therapeutics Clinical Trials Network


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Alternative splicing enables a single gene to produce multiple products and its disruption is a major contributor to many human diseases, including cancers and degenerative disorders. This project will study how disruption of regulatory elements leads to changes in splicing and whether these splicing defects can be interpreted in terms of their causes.

PI_NAMEs: MCGURK, MICHAEL P (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Affect;Alternative Splicing;Back;Binding Proteins;Biological;Biology;career;Characteristics;Communities;Complex;Data;Data Set;Defect;Degenerative Disorder;Development;Disease;Doctor of Philosophy;Environment;Event;Exclusion;Exons;experience;experimental study;Family;field study;flexibility;Future;gene product;Generations;Genes;genetic regulatory protein;Genome;Genomics;Goals;Human;human disease;Individual;knock-down;Large-Scale Sequencing;Lead;Length;Linear Models;Logic;Malignant Neoplasms;Maps;Massachusetts;Mentorship;Methodology;Mutation;Outcome;Pathology;Pattern;Point Mutation;preference;Protein Splicing;Regulation;Regulatory Element;Research;RNA;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;Shapes;Short Tandem Repeat;Site;skills;Source;Statistical Models;Stretching;Structure;Tandem Repeat Sequences;Technical Expertise;Technology;Tissues;tool;Training;Transcript;transcriptome;transcriptomics;Variant;Work

PROJECT_TITLE: Connecting perturbations of RNA binding proteins to their consequences

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Vertebrate genomes from zebrafish to human share deeply conserved non-coding DNA elements (CNEs) that likely act as regulators of neighboring genes. We selected 20 of these DNA elements as they carry risk genetic variations (SNPs) for human health and diseases. In depth analysis of two elements in our list (CNE1 and 19) uncovered the actual genes and the biological process dysregulated in the human traits. Based on this successful proof-of-concepts we propose here to characterize in vivo the remaining 18 elements and associated genetic variations to uncover some of the genetic bases and biological mechanisms affected in 5 human traits for which we have extensive experience and assays.

PI_NAMEs: MOURRAIN, PHILIPPE  (contact);VARSHNEY, GAURAV K

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Affect;Animal Model;Aniridia;base;Biological;Biological Assay;Biological Process;Biology;Blood Vessels;Body Size;Candidate Disease Gene;candidate identification;Cardiovascular system;Cell Line;Chronobiology;circadian;CISH gene;Code;Complex;Conserved Sequence;Coupled;CRISPR/Cas technology;Data;deafness;Defect;detection method;Disease;DNA;DNA Sequence;Elements;Enhancers;Ethnic Population;Evolution;experience;Eye;falls;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Frequency;gene function;Gene Transfer Techniques;Genes;Genetic;Genetic Enhancer Element;Genetic Models;Genetic Risk;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome editing;genome wide association study;Genomic Segment;Growth;Health;Human;Human Biology;human disease;In Situ;in vivo;innovation;insertion/deletion mutation;Laboratories;Light;Link;loss of function;Mediating;Messenger RNA;Methods;model organism;Modeling;Molecular;Molecular and Cellular Biology;Morphology;mutant;Mutation;Neighborhoods;novel strategies;Outcome;Pathology;Pattern;Phenotype;Pigmentation physiologic function;Polydactyly;preservation;Regulation;Regulator Genes;Regulatory Element;Research;Retina;Risk;Role;scoliosis;Skin Pigmentation;Sleep;spatiotemporal;Study models;Synteny;Testing;Time;trait;Triplet Multiple Birth;Untranslated RNA;Validation;Van Buchem disease;vertebrate genome;Work;Zebrafish;zebrafish genome

PROJECT_TITLE: In vivo characterization of CNE/SNPs and identification of cis (dys)regulated genes


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE Despite chemotherapy, acute myeloid leukemia with MLL-rearrangement remains a therapeutic challenge with poor prognosis, and a major barrier to improved outcomes is a lack of mechanism-based, targeted therapies, which requires the discovery of key cancer drivers and gene targets. The proposed research will study a novel dependency of acute myeloid leukemia and dissect the underlying molecular pathways. Knowledge obtained from the proposal will improve our understanding of the transcriptional regulation of MLL-rearranged AML and can be useful for developing targeted therapeutics for this deadly disease.

PI_NAMEs: LU, RUI  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Adult;Affect;Biology;CEBPE gene;Cell Differentiation Induction;Cell Differentiation process;cell growth;cell killing;Cell Line;Cells;chemotherapy;Child;Chimeric Proteins;Chromosomal translocation;comparative;Data;Defect;Dependence;Development;Disease;Disease Outcome;Drug resistance;Enhancers;Failure;Family member;Fusion Oncogene Proteins;Gene Expression;Gene Expression Regulation;Gene Rearrangement;gene repression;Gene Targeting;Genes;Genetic Predisposition to Disease;Genetic Transcription;Genome;Genomic approach;Goals;Growth;Hematologic Neoplasms;hematopoietic differentiation;HOXA9 gene;Human;improved;improved outcome;in vitro Model;in vivo;inhibitor;innovation;insight;Invaded;Knowledge;Laboratories;leukemia;leukemia treatment;Leukemic Cell;leukemogenesis;Lymphoid;Maintenance;Malignant Neoplasms;Mediating;Menin;MLL gene;MLL-rearranged leukemia;Modeling;Molecular;mouse model;Mus;Muscle Development;muscle enhancer factor-2A;Myelogenous;Myeloid Progenitor Cells;myocyte-specific enhancer-binding factor 2;myocyte-specific enhancer-binding-factor 2C;Neurons;new therapeutic target;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Output;paralogous gene;Pathogenesis;Pathway interactions;Patients;Play;preclinical efficacy;Prognosis;programs;Proliferating;protein complex;protein expression;protein function;Proteins;Recurrence;Regulation;Relapse;Repression;Research;Resistance;Role;Sampling;self-renewal;Signal Transduction;targeted treatment;Testing;Therapeutic;Tissues;transcription factor;Transcriptional Regulation;treatment response;tumor;Vertebrates;Work

PROJECT_TITLE: MEF2D-Mediated Transcriptional Control of Acute Myeloid Leukemia

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Services;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Whether to continue breast cancer screening after the age of 74 is a complex clinical decision, and the balance of benefits and harms may vary by patient. The goal of this project is to support decision-making for older women who are considering breast cancer screening by generating individualized estimates of key benefits and harms of screening. We will also develop and pilot a decision aid that incorporates these estimates so that individualized information about the risks and benefits of screening is available to older women who are considering breast cancer screening.

PI_NAMEs: RICHMAN, ILANA  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Age;age group;age-related disease;Aging;American Cancer Society;Area;Award;Benefits and Risks;Biometry;Breast Cancer Detection;Breast Cancer Risk Factor;Cancer Control;cancer prevention;Cessation of life;Clinical;clinically significant;Collaborations;Communication;Complex;Coupled;Data;data access;Data Sources;Decision Aid;Decision Making;design;Development;Diagnosis;Effectiveness;effectiveness testing;effectiveness trial;Environment;Epidemiologic Methods;Epidemiology;Equilibrium;experience;Faculty;Future;Gerontology;Goals;Guidelines;Health;Heterogeneity;Home;improved;Incidence;Individual;Internist;Knowledge;Life Expectancy;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;medical schools;Medicare;Medicare claim;Mentors;Mentorship;Methodology;Modeling;Morbidity - disease rate;mortality;multidisciplinary;neoplasm registry;older adult;older women;Outcome;patient oriented;Patients;personalized decision;Physicians;pilot test;Population;Positioning Attribute;Prevention;Probability;protective effect;Qualitative Methods;randomized trial;Registries;Research;Research Personnel;Risk;Role;screening;Screening for cancer;SEER Program;skill acquisition;skills;success;surveillance data;Techniques;Testing;Time;tool;Training;Uncertainty;United States;United States Preventative Services Task Force;web based decision aid;Woman;women's diagnosis;Work;young woman

PROJECT_TITLE: Supporting Personalized Decision Making for Breast Cancer Screening among Older Women

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE Consumption of sugars, and specifically fructose, has increased dramatically over the past several years. Fructose consumption causes high blood pressure, liver failure, kidney damage and diabetes. Fructose increases salt reabsorption by the kidney; however how it does so is poorly understood. It is also unknown whether the effects of fructose on the kidney cause high blood pressure. This proposal will study these problems.

PI_NAMEs: GARVIN, JEFFREY L. (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: absorption;Adopted;American;Angiotensin II;Angiotensin II Receptor;Angiotensin II Type 1 Receptor Blockers;Blood Pressure;blood pressure elevation;Brush Border;Calories;Cardiovascular Diseases;Cells;Consumption;Cross-Over Studies;Data;Defect;Diabetes Mellitus;dietary;dietary salt;Disease;Diuretics;drinking water;Duct (organ) structure;Enzymes;epithelial Na+ channel;Excretory function;Fructokinases;Fructose;Gene Transfer;glomerular filtration;Glucose;GPI Membrane Anchors;Heart failure;high salt diet;Human;Hypertension;Image;Incidence;inhibitor;insight;Kidney;kidney cortex;Knock-out;Link;Liver Failure;Mediating;Meprin;Messenger RNA;Metabolism;Molecular Biology;Mus;Nephrons;Nephrotic Syndrome;Oxidative Stress;Pathologic;Pathology;Peptide Hydrolases;Persons;Pharmaceutical Preparations;Phospholipase;Phospholipase D;Physiology;Plasma;Play;prevent;Production;Protein Kinase C;Proteins;Rattus;Reactive Oxygen Species;Recommendation;renal damage;Renin-Angiotensin System;Reporting;Role;salt sensitive;salt sensitive hypertension;Sodium Chloride;Source;sugar;Techniques;Testing;Tissues;Trypsin;United States;uptake;urinary;Urokinase;Water

PROJECT_TITLE: The role of the proximal nephron in salt-sensitive hypertension

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

PHR: Project Narrative Induction of tumoricidal functions of tumor-associated macrophages represents a new class of very promising cancer immunotherapy. This study aims to dissect the molecular mechanism regulating antitumor functions of tumor-associated macrophages in triple-negative breast cancer. The understanding of these mechanisms should shed light on the basic principles of cancer immune evasion and inspire the development of novel and effective cancer immunotherapy for triple-negative breast cancer treatment.

PI_NAMEs: FENG, MINGYE  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: anti-cancer;anti-PD-L1 antibodies;Antineoplastic Agents;B-Lymphocytes;Biological Assay;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Treatment;cancer cell;cancer immunotherapy;cancer therapy;CD47 gene;Cell surface;Cell Surface Receptors;Cells;Chemoresistance;chemotherapeutic agent;Clinical Trials;cytotoxicity;Development;Eating;effective therapy;efficacy evaluation;Engraftment;Epidermal Growth Factor Receptor;ERBB2 gene;Estrogen Receptors;Estrogens;Excision;FDA approved;Hematopoietic Neoplasms;Human;Immune;immune cell infiltrate;Immune Evasion;Immune system;Immunologic Surveillance;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Journals;Macrophage;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Molecular;mouse model;Mus;Natural Killer Cells;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Pathway interactions;patient derived xenograft model;Pattern recognition receptor;PD-L1 blockade;pembrolizumab;Phagocytes;Phagocytosis;pre-clinical;Pre-Clinical Model;Primary Neoplasm;Progesterone;Progesterone Receptors;Prognosis;receptor;Resistance;Resistance development;Role;screening;Signal Pathway;Signal Transduction;Site;small molecule;Solid Neoplasm;Subgroup;T-Lymphocyte;Therapeutic;therapeutic target;therapeutically effective;triple-negative invasive breast carcinoma;tumor;Tumor Escape;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;Up-Regulation

PROJECT_TITLE: Targeting tumor-associated macrophages for triple-negative breast cancer treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Two major activated macrophages, classically activated macrophages (M1) and alternatively activated macrophages (M2), play critical roles in various diseases. Manipulation of the M1/M2 macrophage balance has emerged as an attractive approach to the treatment of these diseases, including myocardial infarction and cancer. A noninvasive imaging method to detect M2-like macrophages will provide a powerful tool to monitor disease progression and evaluate the therapeutic efficacy of these emerging therapies.

PI_NAMEs: WANG, CUIHUA  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Advisory Committees;Affinity;Aftercare;analog;Anti-Inflammatory Agents;arginase;Bacteria;bactericide;Binding;Biodistribution;Biological;Biological Assay;biomedical imaging;Cardiopulmonary;cardiovascular imaging;career;CD80 gene;Cells;Colony-Stimulating Factors;Communities;cytotoxicity;Data;design;Detection;Development;Diagnosis;Diagnostic;Disease;Disease Progression;Drug Kinetics;Educational workshop;Equilibrium;Evolution;experience;experimental study;Fibrosis;Fucose;Functional disorder;fungus;Future;General Hospitals;Glioma;Goals;Grant;healing;Heterogeneity;Human;Image;imaging agent;imaging biomarker;imaging modality;imaging probe;Immunology;In Vitro;in vitro Assay;in vivo;in vivo imaging;Inflammation;Inflammatory;inhibitor;instructor;Interferon Type II;Interleukin-10;Interleukin-4;Knowledge;Ligands;Lung Carcinoma;Macrophage;Magnetic Resonance Imaging;Malignant Neoplasms;Mannose;mannose receptor;Maps;Massachusetts;medical schools;meetings;Mentorship;Monitor;mouse model;Myocardial Infarction;Natural Immunity;Neoplasm Metastasis;non-invasive imaging;pathogenic virus;Pathologic;Pathologic Processes;personalized medicine;Phenotype;Play;preclinical study;Production;prototype;Pulmonary Heart Disease;Radiology Specialty;repaired;Reporting;Research;Research Personnel;response;Role;screening;Sensitivity and Specificity;Skin wound healing;spatiotemporal;Structure-Activity Relationship;Surface;symposium;Systems Biology;targeted agent;Technology;therapeutic target;tissue repair;Tissues;TNF gene;tool;Training;Translating;Translations;Treatment Efficacy;treatment response;tumor;tumor growth;Tumor Promotion;Tumor-associated macrophages;wound healing;Wound models;Writing

PROJECT_TITLE: Tracking M2-Like Macrophages in Cardiopulmonary Diseases by Magnetic Resonance Imaging

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

PHR: There is a shortage of researchers trained in both biostatistics and epidemiology with expertise in cardiovascular disease. The objective of the proposed program is to provide cross-training to biostatisticians and epidemiologists, who can become future leaders in cardiovascular disease research investigation.

PI_NAMEs: IRVIN, MARGUERITE R;TIWARI, HEMANT K. (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TITLE: UAB Cardiovascular Disease Predoctoral Training Program in Biostatistics and Epidemiology

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Bioengineering

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative  Our goal is to obtain a fundamental understanding of how the cytoskeletal motors interact with proteins, lipid  membranes, and other biomolecules to power structural arrangements and motile events that are crucial for  eukaryotic life. The cytoskeleton and its molecular motors touch nearly all aspects of normal cell function, as  these proteins are frequently at the nexus of key signaling and developmental pathways. Additionally, there is  a growing appreciation and demonstration that cytoskeletal proteins, molecular motors, and cytoskeletal  adaptors are viable therapeutic targets. Thus, a molecular understanding of cytoskeletal function is of direct  health relevance.

PI_NAMEs: OSTAP, E. MICHAEL (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Acetylation;Actins;Active Sites;Adaptor Signaling Protein;Address;Adhesions;Affect;Affinity;arm;Back;Binding;Binding Proteins;Binding Sites;Biochemical;Biochemistry;Biological;biophysical tools;Biophysics;Cadherins;Calibration;Cardiac;Cell Physiology;Cell-Cell Adhesion;Cells;Cellular biology;Collaborations;Communities;Contracts;Coupled;Coupling;Cryoelectron Microscopy;Cytoskeletal Proteins;Cytoskeleton;design;Development;dimer;disease-causing mutation;Drosophila genus;E-Cadherin;Engineering;Event;experimental study;Family;feeding;Fluorescence Resonance Energy Transfer;force sensor;Funding;Generations;Geometry;Goals;graduate student;Growth;Health;Heart;In Vitro;Individual;inorganic phosphate;insight;Intestines;Intracellular Transport;Intuition;Investigation;Investments;kinetic model;Kinetics;Laboratories;Left;Life;Literature;Measurement;Measures;mechanical force;mechanical load;mechanical properties;Mechanics;mechanotransduction;Mediating;member;Membrane;Membrane Lipids;Methods;MgADP;Microfilaments;Modeling;Molecular;Molecular Conformation;Molecular Motors;Molecular Probes;Motility;Motor;Motor Pathways;Myosin ATPase;Myosin S-1;Myosin Type I;N-terminal;Normal Cell;novel;optic trap;optical traps;Organism;Outcome;Output;Paper;Pathway interactions;Pattern;Phosphatidylinositols;Phylogenetic Analysis;physical property;Physiological;planar cell polarity;Play;polymerization;Polymers;Population;Positioning Attribute;Post-Translational Protein Processing;Preparation;prevent;Process;programs;Progress Reports;Property;protein complex;Protein Isoforms;Proteins;Publications;Publishing;rate of change;recruit;Regulation;Reporting;Research;Research Support;Resolution;response;Role;Rotation;Series;Signal Transduction;single molecule;Site;Skeletal Muscle;Smooth Muscle;Speed;stem;Structure;Subgroup;System;Tail;Techniques;Testing;therapeutic target;Time;Tissues;tool;tool development;Touch sensation;Tropomyosin;virtual;Work

PROJECT_TITLE: Molecular function of Myosin-l

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Depression is a recurrent illness and even with successful antidepressant treatment, older adults with late-life depression are at high risk of recurrence. However, neurobiological processes that contribute to vulnerability to recurrence are poorly understood, limiting our ability to target mechanisms in prevention studies. The current study will elucidate neurobiological contributors to recurrence, examine the interrelationship between recurrence and cognitive decline, and provide data on the predictive utility of clinical monitoring in older adults.

PI_NAMEs: AJILORE, OLUSOLA A. (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Acceleration;actigraphy;Affect;Affective;aging brain;anti-depressive agents;Behavioral;Clinical;clinical practice;Cognitive;cognitive function;cognitive load;cognitive performance;Data;Depressed mood;depressive symptoms;Development;Disease remission;Early Diagnosis;Ecological momentary assessment;Elderly;Environmental Monitoring;Equilibrium;executive function;Exhibits;experience;Functional Magnetic Resonance Imaging;Future;geriatric depression;Goals;high risk;Homeostasis;Impaired cognition;Individual;Laboratories;Longitudinal Studies;Measures;Mental Depression;Monitor;mood symptom;Moods;negative affect;network models;neural;neural network;Neurobiology;neuroimaging;Noise;older adult;Participant;Performance;Predictive Factor;predictive marker;Prevention;Process;prospective;Recording of previous events;Recovery;Recurrence;recurrent depression;Regulation;Reporting;Residual state;Risk;Risk Marker;rumination;Severities;Signal Transduction;single episode major depressive disorder;Site;Sleep;Stress;stress reactivity;Subgroup;Symptoms;Testing;Therapeutic Intervention;Time;Translating;young adult

PROJECT_TITLE: 3/3-Recurrence markers, cognitive burden and neurobiological homeostasis in late-life depression


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Eye Disease and Disorders of Vision;Immunotherapy;Neurosciences

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Research Narrative/Statement: Autoimmune ocular inflammation can lead to permanent blindness due to the irreversible damage caused by autoreactive inflammatory cells. Identifying factors involved in the inflammatory cell entry into the retina and subsequent antigen presentation during uveitis is of significant value. Our work has identified resident microglia in the retina as facilitators of immune cell entry in the initiation of autoimmune uveitis; this proposal aims to define key target cells and molecules that allow for autoreactive immune cells to target the neuroretina in this neuroinflammatory disease.

PI_NAMEs: GREGORY-KSANDER, MEREDITH ;KSANDER, BRUCE R (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;Accounting;Adoptive Transfer;Anti-CD47;Antibodies;Antigen Presentation;Antigen Targeting;Antigen-Presenting Cells;Antigens;Astrocytes;Autoantigens;Autoimmune;Autoimmune Responses;autoimmune uveitis;autoinflammatory;autoreactivity;Blindness;Blood-Retinal Barrier;CD47 gene;cell type;Cells;Central Nervous System;Chronic;cytokine;Data;Development;Disease;Disease Progression;Endothelial Cells;Etiology;Experimental Models;Eye;Goals;Immune;immune cell infiltrate;Immune response;Immune system;Immunization;Immunosuppression;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;Kinetics;Leukocytes;Maintenance;Mediating;MHC Class II Genes;Microglia;Modeling;mouse model;Muller's cell;Mus;neovascular;neural;neuroinflammation;Optic Nerve;Pathogenesis;Patients;Phagocytosis;pharmacologic;Phenotype;Photoreceptors;Population;Prevalence;prevent;Production;PTPNS1 gene;Reaction;receptor;recruit;Regulation;Reporting;Research;response;Retina;RNA Sequences;Role;Sarcoidosis;Secondary to;single-cell RNA sequencing;Syndrome;Systemic disease;T-Lymphocyte;Testing;Time;Tissues;Transgenic Mice;Transgenic Organisms;Uveitis;Uveomeningoencephalitic Syndrome;Vision;Visual impairment;Work

PROJECT_TITLE: Regulation of the neuroinflammatory response in autoimmune uveitis