NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Neurosciences;Precision Medicine;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE In this grant, we propose to identify biomarkers of response and resistance to immunotherapy and potentially new therapeutic targets for patients with brain metastases from breast cancer. Our application is relevant to the public health because there are limited effective systemic therapies for patients with brain metastases. Relevant to the NIH mission, the overarching objective of this study is to identify genetic alterations that are associated with progression in patients with brain metastases receiving immunotherapy, and to explore novel combination therapies, with the goal to identify optimal therapeutic approaches for this common neoplasm.

PI_NAMEs: BRASTIANOS, PRISCILLA KALIOPI (contact);ELLISEN, LEIF W

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Aftercare;Anatomy;angiogenesis;anti-PD-1;Antigen Presentation;Automobile Driving;biomarker identification;Blood;Brain;breast cancer metastasis;cancer cell;cancer complication;cancer genetics;cancer genome;cancer type;candidate identification;Carcinomatosis;CDK4 gene;CDKN2A gene;cell behavior;Cells;Central Nervous System;Cephalic;Cerebrospinal Fluid;chemotherapy;Clinical;Clinical Data;Clinical Trials;Clonal Evolution;Clonal Expansion;Combined Modality Therapy;Common Neoplasm;Complication;computerized tools;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinases;Data;Development;Disease;Exclusion;exhaustion;exome sequencing;Failure;Flow Cytometry;Future;Genetic;Genetic Determinism;Genetic Drift;Genetic Fingerprintings;Genetic Transcription;Goals;Grant;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;immunogenicity;Immunologics;Immunosuppression;Immunotherapy;improved;innovation;Interferons;Leptomeninges;Lesion;Link;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Central Nervous System;Mission;Modeling;mouse model;Mutation;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;Pathway interactions;patient subsets;Patients;pembrolizumab;peripheral blood;pharmacologic;phase II trial;Phenotype;Population;Pre-Clinical Model;pressure;primary endpoint;Primary Neoplasm;Prognosis;Protocols documentation;Public Health;recruit;refractory cancer;Repression;Resistance;resistance mechanism;Resolution;response;response biomarker;RNA;Role;Sampling;single cell analysis;single cell sequencing;single cell technology;single-cell RNA sequencing;Site;Systemic Therapy;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Time;Tissues;translational potential;Treatment Failure;treatment strategy;triple-negative invasive breast carcinoma;tumor;Tumor Expansion;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;United States National Institutes of Health;Work

PROJECT_TITLE: Elucidating resistance mechanisms and enhancing response to immune checkpoint blockade in central nervous system metastases from breast cancer

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Influenza A virus induces respiratory disease, produces yearly seasonal outbreaks, and has pandemic potential. Currently, there is a limited understanding about how the virus transmits and how this influences infection. This research aims to address this gap with the goal of informing interventions that will limit viral spread.

PI_NAMEs: VARGAS-MALDONADO, NAHARA  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Address;aerosolized;Aerosols;Air;Anatomy;Animals;Bar Codes;Breathing;California;Cavia;Climate;Coughing;Data;Deposition;Development;Disease Outbreaks;dosage;Dose;Economics;effective intervention;Environment;Environmental Impact;Environmental Risk Factor;exposure route;Exposure to;flu transmission;Frequencies;Gene Expression;Gene Expression Profiling;Genetic;Genotype;Goals;Human;Humidity;Immune;Immune response;Immunity;Individual;Infection;Inflammatory;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;influenza virus strain;Innate Immune Response;insight;Intervention;Knowledge;Libraries;Location;Lower respiratory tract structure;Mediating;Methods;Modeling;Monitor;Mucous Membrane;Nose;Outcome;Panama;pandemic potential;particle;Pathway interactions;Predisposition;Process;Property;Research;Respiratory Disease;Respiratory Mucosa;Respiratory System;Role;Route;Seasons;Site;Sneezing;Societies;Surface;Temperature;Testing;Time;Touch sensation;transcriptome sequencing;transmission process;Travel;Upper respiratory tract;Viral;viral transmission;Virus;Virus Diseases

PROJECT_TITLE: From exposure to infection: defining factors modulating the efficiency of influenza A virus infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

PHR: NARRATIVE Global influenza vaccination strategies need improvement due to limited seasonal efficacy resulting from changes in surface proteins of the circulating influenza virus variants. Upper respiratory tract CD8+ tissue- resident memory T cells (TRM) offer durable protection against influenza since these cells target highly conserved, internal influenza epitopes. This proposal aims to define the signals that mediate CD8+ TRM development, maintenance, and longevity in the upper respiratory tract, which will inform respiratory virus vaccination efforts to limit severe respiratory tract infection.

PI_NAMEs: KOST, KIRSTEN  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Address;Adoptive Transfer;Antibodies;Antibody-mediated protection;Antigens;Appearance;Automobile Driving;CD8B1 gene;Cell Maintenance;Cells;Cellular Immunity;Cessation of life;conditional knockout;Cre lox recombination system;Cytokine Signaling;Data;Dependence;Deposition;Development;differential expression;Disease;Epitopes;Generations;global health;Health;Hospitalization;Human;Humoral Immunities;Immune;Immunity;Immunocompromised Host;improved;in vivo;Individual;Infection;Influenza;Influenza A virus;influenza infection;Influenza vaccination;influenza virus strain;influenza virus vaccine;influenzavirus;insight;Interleukin-15;intraperitoneal;Knock-out;Knockout Mice;Knowledge;Larynx;Longevity;Lower Respiratory Tract Infection;Lower respiratory tract structure;Lung;Maintenance;Mediating;Membrane Glycoproteins;Membrane Proteins;Microscopy;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;Nasal cavity;neutralizing antibody;novel;Nucleoproteins;pandemic potential;Parabiosis;Pathogenicity;Pharyngeal structure;Play;Polymerase;pressure;prevent;Process;Proteins;Reporting;respiratory;Respiratory System;Respiratory Tract Infections;respiratory virus;Role;Route;seasonal influenza;Seasons;Signal Transduction;System;T-Cell Development;Tamoxifen;Time;tissue resident memory T cell;transcriptome sequencing;Transforming Growth Factor beta;Upper respiratory tract;Vaccination;vaccination strategy;vaccine delivery;vaccine strategy;Vaccines;Variant;Viral;Viral Pneumonia;Virus Replication;Work

PROJECT_TITLE: CD8+ TRM Development and Maintenance in the Upper Respiratory Tract


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: CHICAGO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE HIV-1 undergoes multiple morphological transformations during its life cycle including assembly of the immature virion, maturation of the viral core, and uncoating among many others. Due to the necessity of each of these transitions for viral infectivity, drugs that inhibit these processes or lead to off-pathway structures have great potential as antiretroviral therapies. In this work, a series of multi-scale computational investigations, in conjunction with leading experimentalists, will unveil the molecular mechanisms involved in these morphological transformations.

PI_NAMEs: WALTMANN, CURT  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Affect;antiretroviral therapy;Binding;Biological;Capsid;Capsid Proteins;Cell membrane;Cell Nucleus;Cells;Characteristics;Charge;Cleavage And Polyadenylation Specificity Factor;Collaborations;Colorado;Complex;Computing Methodologies;Crosslinker;Data;design;DNA;DNA Integration;Drug Targeting;Encapsulated;experimental study;Filopodia;Free Energy;Future;gag Gene Products;Genetic Transcription;Grain;Growth;HIV;HIV-1;HIV-1 protease;In Vitro;innovation;Integrase;Integrase Inhibitors;Integration Host Factors;Investigation;Lead;Life Cycle Stages;Lipids;live cell imaging;Maps;medical schools;Membrane;Modeling;Molecular;molecular dynamics;Morphology;mutant;Mutation;Nucleocapsid;Nucleocapsid Proteins;Paint;Pathway interactions;Pharmaceutical Preparations;Phosphatidylinositol 4,5-Diphosphate;Physical condensation;physical property;Polymers;pressure;prevent;Process;Property;Proteins;Research;Resolution;Reverse Transcription;Ribonucleoproteins;RNA;RNA Folding;RNA-Directed DNA Polymerase;RNA-targeting therapy;Rod;Role;Rupture;Sampling;self assembly;Series;Shapes;simulation;Structure;Techniques;Tertiary Protein Structure;Testing;Therapeutic;Time;Transcription Process;United States National Institutes of Health;Universities;Viral;viral DNA;Viral Genome;Viral Packaging;viral RNA;Virion;Virus;Work

PROJECT_TITLE: Assembly and Disassembly Processes in the HIV-1 Life Cycle

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17A-G (20)]


ADMINISTERING_IC: DK

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative The development of treatment options for insulin-dependent diabetics with islet cells, which provide physiological regulation of glucose, could result in dramatic improvements in quality of life, as well as a substantial decrease in disease management complications. Herein, we seek to develop a bioactive macro-scale implant that serves to promote healthy host engraftment and vascularization of the implant, while also reducing the need for anti- rejection drugs, which should significantly enhance treatment options for insulin-dependent diabetics. We believe these studies are highly relevant to the mission of the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) and are designed to result in a significant impact on public health.

PI_NAMEs: LANSBERRY, TAYLOR ROSE (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: 3-Dimensional;3D Print;adaptive immune response;Address;Affect;Allogenic;Allografting;Autoimmune Diseases;Beta Cell;Biocompatible Materials;biomaterial compatibility;bioscaffold;Blood Glucose;blood glucose regulation;Cadaver;Cell Physiology;Cell Therapy;Cells;chronic autoimmune disease;Clinical;Custom;Cytoprotection;Data;design;Designer Drugs;Devices;diabetic;diabetic rat;Diagnosis;Disease;Disease Management;draining lymph node;drug release kinetics;Encapsulated;Engineering;Engraftment;fabrication;Fibrosis;flexibility;Foreign Bodies;Geometry;glycemic control;Goals;Hydrogels;Immune;immune modulating agents;Immune response;Immune system;Immunocompetence;immunoreaction;immunoregulation;Immunosuppression;Immunosuppressive Agents;Impairment;Implant;implantation;improved;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Infusion procedures;Infusion Pumps;Injections;Innate Immune Response;insight;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;Islet Cell;Islets of Langerhans;Islets of Langerhans Transplantation;Kinetics;Liver;local drug delivery;Mechanical Stress;Mechanics;Membrane;Methods;Microcapsules drug delivery system;Microspheres;Mission;Modeling;Motivation;National Institute of Diabetes and Digestive and Kidney Diseases;Outcome;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Physics;Physiological;Play;polydimethylsiloxane;Porosity;preservation;prevent;prototype;Public Health;Quality of life;Rattus;Reproducibility;Research Personnel;response;Risk;Role;scaffold;Site;Stress;Surface;T-Lymphocyte;Techniques;Therapeutic;therapeutic evaluation;therapy development;Thick;Tissues;Translating;transplant model;Treatment Efficacy;United States;Vascularization;Work

PROJECT_TITLE: Engineering a Multi-Therapeutic, 3D-Printed Scaffold for Local Immunoprotection and Favorable Engraftment of Pancreatic Islets for Treatment of Type 1 Diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: PROJECT NARRATIVE Individuals residing in low-income minority neighborhoods often suffer from disproportionately high levels of obesity and other diet-related health conditions. We will conduct multilevel-multicomponent community nutrition interventions addressing multilevel factors that influence food access and dietary behaviors of families with school-aged children in low-income minority neighborhoods.

PI_NAMEs: GRAY, HEEWON L. (contact);STERN, MARILYN

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: access disparities;Address;Affect;African American;African American population;Age;Awareness;Behavior;behavior change;Behavioral;Benchmarking;Biological;Black race;Blood Pressure;Body mass index;Cardiovascular Diseases;Caregivers;Child;Child Behavior;Child Rearing;Chronic Disease;cohort;Communities;community organizations;cooking;Data;density;Diabetes Mellitus;Diet;Diet Habits;dietary;Dietary Assessment;Dietary intake;Dietary Intervention;Disadvantaged;Disease;Disparity;Education;Educational Status;Educational workshop;efficacy trial;Environmental Risk Factor;evidence base;Family;feasibility trial;Feedback;Florida;Focus Groups;Food;Food Access;food environment;food insecurity;fruits and vegetables;Future;Goals;Health;Health Disparities Research;Health Food;Healthy Eating;Hip region structure;Household;implementation intervention;implementation measures;improved;Individual;Inequity;innovation;Intervention;Link;Low income;Measurement;meetings;Methods;Minority;minority communities;minority health;minority health disparity;Modeling;multi-component intervention;National Institute on Minority Health and Health Disparities;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;nutrition education;Obesity;obesity risk;Outcome;Outcome Measure;Parents;Participant;Phase;pilot test;Political Factor;Prevalence;promote resilience;Protocols documentation;Psychosocial Factor;Randomized;Randomized, Controlled Trials;recruit;Reduce health disparities;Reporting;Research;School-Age Population;Series;social;social culture;social health determinants;Societal Factors;sociocultural determinant;Strategic vision;Structural Racism;Supermarket;Support System;Time;tool;Trauma;trial design;Unhealthy Diet;United States Department of Agriculture

PROJECT_TITLE: Community-derived Multilevel-Multicomponent Nutrition Intervention to Reduce Food Access Disparities -FRESH-EATS

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Regenerative Medicine

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE The axolotl salamander is able to perfectly regenerate complex structures, including whole limbs. This project will investigate the regulation of chromatin compaction in fibroblasts by retinoic acid signaling that modifies gene expression to establish the regenerating limb’s proximodistal axis. These studies are critical to understanding the regulatory pathways by which retinoic acid acts and how these mechanisms promote limb regeneration in the axolotl, which may potentiate novel therapeutic targets for tissue regeneration in humans.

PI_NAMEs: MILLER, MELISSA NANETTE (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Ablation;Ambystoma;Amputation;ATAC-seq;Biological;Biological Assay;blastema;Candidate Disease Gene;candidate identification;Catabolism;Cell Nucleus;cell type;Cells;Chromatin;Chromosome Mapping;Cicatrix;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Connective Tissue;Cues;CYP26B1 gene;Cytochrome P450;Cytoplasm;Defect;Development;Digit structure;Distal;DNA;DNA Binding;Dose;Enhancers;Epigenetic Process;epigenetic regulation;Exhibits;experimental study;Family;Family member;Fibroblasts;Forelimb;Gene Expression;Genes;Genetic;Genetic Enhancer Element;Genetic Transcription;Genomics;Hand;Human;In Situ;Injury;insight;limb regeneration;Limb structure;macromolecule;Memory;Methods;Modeling;Modification;Molecular;Molecular Conformation;morphogens;multiple omics;Natural regeneration;new therapeutic target;novel;Nuclear;Nucleic Acid Regulatory Sequences;Pattern;Phenotype;predictive test;Process;programs;promoter;Property;Proteins;receptor;regenerative;Regenerative capacity;regenerative therapy;Regulation;Regulatory Element;Regulatory Pathway;Reporter;Resolution;response;Retinoic Acid Binding;Retinoic Acid Response Element;RNA;Role;Salamander;Shoulder;Signal Transduction;Site;spatiotemporal;Specific qualifier value;Structure;Techniques;Testing;Time;tissue regeneration;Tissues;Training;transcription factor;Transcriptional Regulation;transcriptome sequencing;Tretinoin;Upper arm;Visualization;Work;Wrist

PROJECT_TITLE: Epigenetic regulation of the regenerating axolotl forelimb's proximodistal axis by retinoic acid

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Orphan Drug;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Patients suffering from inv3/(3;3) myeloid leukemias experience low 5-year survival rates (<5%) as a result of a lack of targeted therapies and poor response to standard treatment regimens such as bone marrow transplant in combination with chemotherapy. This work will utilize innovative proteogenomic approaches to identify actionable targets for pharmacological studies and provide key mechanistic insights into the historically “undruggable” inv3/(t3;3) myeloid leukemia cancer cell biology. As a result of this work, I anticipate an addition to research on inv3/t(3;3) myeloid leukemias, with a long term impact of improving overall quality of and length of life for patients.

PI_NAMEs: TURMON, ALEXANDRA CHLOE (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Affect;Area;Biology;bone marrow failure syndrome;Bone Marrow Transplantation;cancer cell;Cancer Vaccines;Cathepsins;Cell Line;Cell surface;Cell Survival;Cells;Cellular biology;chemotherapy;Chromosomal Rearrangement;Chromosome 3;Code;Communities;Complex;Data;Development;developmental disease;Disease;Disease Progression;DNA Sequence Alteration;Embryo;EVI1 gene;experience;Future;Gene Combinations;Gene Expression;Genes;Genomics;Health;Hematopoiesis;Hematopoietic stem cells;HLA-DPB1 gene;Human;IL16 gene;improved;Inherited bone marrow failure;innovation;insight;Interleukin-16;Lead;leukemia;Longevity;Malignant Neoplasms;Mediating;Methodology;Methods;Mutation;Myeloid Leukemia;myeloid leukemia cell;N-terminal;Nature;novel;novel strategies;Oncogenic;overexpression;Pathway Analysis;Patients;Peptide Hydrolases;Pharmacology Study;Precision therapeutics;Production;Protein Isoforms;Proteins;proteogenomics;Proteome;Proteomics;pyridine;Regimen;Reporting;Research;Resistance;response;Rodent;Role;Signal Pathway;Signal Transduction;Signaling Protein;standard care;standard of care;Survival Rate;targeted treatment;Technology;Testing;Therapeutic;therapeutic development;therapeutic target;therapy development;Transcript;transcription factor;Transcriptional Regulation;transcriptome sequencing;Translation Process;Treatment Protocols;tumor;Tumor Suppressor Proteins;tumorigenesis;Tyrosine Kinase Inhibitor;Umbilical Cord Blood;Vaccine Therapy;Validation;Work

PROJECT_TITLE: Deciphering inv3/t(3;3) Myeloid Leukemia Vulnerabilities via Proteogenomics and N-terminal Proteomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09A-R (20)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  Survival requires the accurate prediction of threats at diverse proximity, and aberrant threat computation processes underlie psychiatric disorders such as post-traumatic stress disorders. However, the neural substrates of determining temporal proximity of incoming threats have not been well determined. The proposed work seems to elucidate how the neuromodulator norepinephrine, the second messenger cyclic AMP, and cellular activity in the prefrontal cortex encode temporal threat proximity and underlie adaptive defensive behaviors.

PI_NAMEs: BASU, AAKASH  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Affect;Anatomy;Aversive Stimulus;Behavior;Behavioral;behavioral response;Biosensor;Calcium;Communication;Cues;Cyclic AMP;Data;Disease;Distant;Educational process of instructing;Environment;Event;Fellowship;Fluorometry;Fright;frontal lobe;Future;G-Protein-Coupled Receptors;Goals;Image;improved;in vivo;in vivo calcium imaging;Individual;Investigation;learned behavior;Learning;Link;locus ceruleus structure;Measurement;Measures;Medial;Mediating;Memory;Mental disorders;Mentorship;Modeling;Molecular;neural;neural circuit;Neuromodulator;Neurons;Neurosciences;noradrenergic;Norepinephrine;novel;optogenetics;Outcome;Post-Traumatic Stress Disorders;Prefrontal Cortex;Preparation;Process;Psychological reinforcement;Research;response;Role;Science;Second Messenger Systems;Signal Transduction;Stimulus;System;Techniques;Testing;therapy development;Time;tool;Training;treatment strategy;Work

PROJECT_TITLE: Norepinephrine and second messenger encoding of temporal threat proximity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE The publication of addiction science is highly skewed with underrepresentation in knowledge production and dissemination from people from underrepresented and minoritized population, individuals from low- and middle- income countries and people from non-English-speaking countries. The annual meeting of the International Society of Addiction Journal Editors (ISAJE) is an important forum where important knowledge about addiction science publishing is shared and developed. By being supported to attend the annual ISAJE meetings, increased numbers of editors from underrepresented populations will gain knowledge about addiction editing which will enhance the participation of underrepresented individuals in addiction production and dissemination in the long run.

PI_NAMEs: WILLIAMS, EMILY CATERINA (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: addiction;Address;Alcohols;Award;Canada;career;Case Study;clinical practice;Collaborations;cost;Country;Decision Making;Disabled Persons;disadvantaged background;Discrimination;Disparity;Disparity population;Drug Addiction;Drug usage;editorial;Education;Educational workshop;Equity;equity, diversity, and inclusion;Ethics;ethnic minority population;Ethnic Population;Exposure to;Five-Year Plans;Fostering;Foundations;gender minority group;generative artificial intelligence;Goals;Grant;improved;Income;Individual;International;Journals;Knowledge;Leadership;Learning;lens;Location;low and middle-income countries;meetings;Meleagris gallopavo;member;Minority Groups;Mission;Names;National Institute of Drug Abuse;Paper;Persons;Pharmaceutical Preparations;Population;Portugal;Process;Production;Public Health;Publication Bias;Publications;Publishing;Racial Equity;racial minority population;racism;recruit;Research;research data dissemination;Research Personnel;Resources;Sampling;Science;skills;Societies;South Africa;Substance abuse problem;success;symposium;Training;Travel;Underrepresented Populations;United States National Institutes of Health;Woman;World Bank

PROJECT_TITLE: Annual Conference of the International Society of Addiction Journal Editors: Preparing an underrepresented workforce for editorial board leadership

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 IXR-X (M1)]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Genetics;Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative  The proposed research develops and validates a platform to perform functional assessment of MYH7 variants in parallel in a high throughput fashion, which will inform a contrastive machine learning model to predict additional variants. The results will be validated both by high throughput functional assays and detailed structure function study of myosin. Once completed, we will be able to ascertain pathogenicity of all current and future MYH7 variants and use this information to direct patient care; our strategy can be readily adopted to interpret other inherited cardiomyopathies and other genetic conditions.

PI_NAMEs: KIRK, JONATHAN A;SAMEE, MD. ABUL HASSAN ;ZHANG, LILEI  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Adopted;Affect;Amino Acids;Artificial Intelligence;Bar Codes;beta-Myosin;Biological Assay;Biology;Calcium;Cardiac Myocytes;Cardiac Myosins;Cardiomyopathies;Cell Line;Cell Size;Cells;Cellular Stress;Clinic;Clinical;clinical diagnostics;clinical practice;clinically relevant;ClinVar;Communities;Data;Databases;Defect;design;Development;direct patient care;Engineering;experimental study;Family member;Feedback;Foundations;Future;gain of function;gain of function mutation;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;Genetic Diseases;genetic testing;genetic variant;Genotype;Heart Diseases;Human;human induced pluripotent stem cells;Human Pathology;Hypertrophic Cardiomyopathy;Image;improved;Individual;induced pluripotent stem cell;inherited cardiomyopathy;innovation;Integrase;interest;Libraries;Machine Learning;machine learning algorithm;machine learning model;Measurement;Measures;Microfilaments;Missense Mutation;mitochondrial metabolism;Molecular Diagnosis;molecular phenotype;mouse model;Mutation;Myosin ATPase;Myosin Heavy Chains;National Human Genome Research Institute;Neck;Nonmuscle Myosin Type IIA;novel;Other Genetics;Outcome;Pathogenicity;Pathology;Patient Care;patient derived induced pluripotent stem cells;Patients;Performance;Persons;Phenotype;pluripotent stem cell differentiation;Population;precision medicine;Privatization;protein structure;Proxy;Reactive Oxygen Species;Recommendation;Reporter Genes;Reporting;Research;Resolution;response;Rod;Sampling;Sarcomeres;single cell sequencing;single-cell RNA sequencing;Site;Structure;System;Technology;Testing;Time;tool;Training;Uncertainty;Validation;Variant;variant of unknown significance;X ray diffraction analysis

PROJECT_TITLE: Broadly applicable high throughput variant interpretation and validation for MYH7

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE Malignant gliomas are devastating forms of brain cancer that remain incurable in nearly all patients. In this proposal, we aim to uncover the cellular and molecular mechanisms that regulate neurodevelopmental lineage malignant reprogramming and plasticity that mediates rapid adaptation to targeted oncogene inhibition in these deadly tumors. Using advanced single-cell lineage tracing techniques, quantitative proteomics, and state-of-the- art preclinical models and drugs, this work will yield mechanistic insights into oncogenic regulation of neurodevelopmental identity in glioma and examine whether rationally designed targeted therapy combinations can overcome adaptive resistance to produce more efficacious therapeutic strategies.

PI_NAMEs: CADET, DIMITRI  (contact)

PROJECT_TERMS: Ablation;Adult;Affect;American;Astrocytes;Automobile Driving;Bar Codes;BRAF gene;Brain;Brain Neoplasms;cancer cell;Cell Lineage;Cell Physiology;Cells;Clinical;clinical development;cohort;Combined Modality Therapy;Complex;Coupled;Cytotoxic Chemotherapy;Data;Development;Disease;Disease Progression;DNA Sequence Alteration;Down-Regulation;Drug resistance;Drug Targeting;Environment;Epidermal Growth Factor Receptor;Evolution;Gene Expression;gene therapy;Genetic;Genetic Transcription;Glioblastoma;Glioma;Goals;Heterogeneity;Human;In Vitro;in vitro Model;Individual;innovation;insight;Link;Malignant - descriptor;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;MAP Kinase Gene;Mediating;Modeling;Molecular;molecular targeted therapies;Multipotent Stem Cells;Mutate;neoplastic cell;nerve stem cell;neural;neurodevelopment;Neuroglia;Neurons;non-genetic;novel;Nuclear Pore Complex;oligodendrocyte progenitor;Oligodendroglia;Oncogenes;Oncogenic;Organoids;patient derived xenograft model;Patients;pediatric low grade glioma;personalized therapeutic;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;pre-clinical;Pre-Clinical Model;pressure;Process;progenitor;programs;Proliferating;Protein-Serine-Threonine Kinases;Proteomics;Proto-Oncogene Proteins B-raf;Radial;rational design;receptor expression;Receptor Inhibition;Receptor Signaling;Regulation;Reporter;Resistance;Resolution;response;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem;stem cells;subcutaneous;success;System;targeted treatment;Techniques;Therapeutic;Therapeutic Intervention;therapy resistant;transcriptomics;treatment strategy;tumor;tumor heterogeneity;tumor initiation;Work;Xenograft procedure

PROJECT_TITLE: Brain microenviornment-dependent lineage plasticity drives adaptation to targeted therapy in malignant gliomas

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-C (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Financial security has been identified as a determinant of violence and safety, yet this relationship has not been examined for sexual and gender diverse (SGD) populations despite experiencing disproportionately high rates of violence and facing vulnerability across multiple dimensions of financial security. The proposed study will utilize quantitative, qualitative, and policy evaluation research designs to examine the role of financial security and the impact of policy in shaping SGD violence disparities. Findings from this study will contribute to the evidence base on economic determinants of SGD population health and inform upstream violence prevention strategies in alignment with NIMHD’s strategic plan to address minority health disparities.

PI_NAMEs: KENNEDY, KATRINA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Active Learning;Address;Advocate;Affect;Assistantship;Attention;Automobile Driving;Baltimore;behavioral health;career;Cities;comparative;Crime;Data;Data Analyses;Data Pooling;Degree requirements;design;Dimensions;Discrimination;Disparity;disparity reduction;doctoral student;economic determinant;Education;Educational workshop;Eligibility Determination;Employment;Epidemiologic Methods;evidence base;experience;federal poverty level;Feeling;Foundations;gender diverse;Gender Identity;German population;Goals;Health;Health Disparities Research;health disparity;health equity;Household;improved;Income;Income Tax;Individual;Infrastructure;innovation;insight;Interruption;Intervention;Interview;Investigation;Lead;Life Cycle Stages;life span;Mental Health;Mentors;Mentorship;Methods;minority health;minority health disparity;minority stressor;Modeling;multidisciplinary;National Institute on Minority Health and Health Disparities;nonbinary;Outcome;Pathway interactions;Personal Satisfaction;Persons;physical conditioning;Policies;Policy Analysis;Population;population health;Population Heterogeneity;Poverty;Prevention strategy;protective effect;Public Health;Public Health Schools;Public Policy;Qualitative Evaluations;Qualitative Research;Quantitative Evaluations;Research;Research Design;Research Personnel;Risk Factors;Role;Safety;Scientist;secondary analysis;Security;Series;Services;sexual identity;Sexual violence prevention;Shapes;skills;social;social determinants;social epidemiology;Social Sciences;social skills;social stigma;Societal Factors;Strategic Planning;structural health determinants;Surveys;System;Time;Training;training opportunity;transgender;Translational Research;Unemployment;Victimization;Violence;violence prevention;violence victimization;Wages

PROJECT_TITLE: Characterizing Economic Determinants of Violence and Safety Disparities Among Sexual and Gender Diverse Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Early puberty increases the risk of adverse health outcomes over the life course, including mental health conditions, diabetes, cancer, and cardiovascular disease. During the COVID-19 pandemic, pediatric endocrinology centers across several countries reported large increases in early puberty diagnoses; however, there is currently no epidemiologic data on pandemic-related changes in early puberty in the United States. Using electronic health records from the nation’s largest integrated healthcare system, this study will assess pre–post pandemic changes in precocious puberty diagnoses and timing of pubertal milestones in the general population, with a focus on identifying subgroups most impacted by these changes to inform health equity initiatives and future pandemic response.

PI_NAMEs: ACKER, JULIA  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: 6 year old;Acceleration;Address;Adolescence;Adolescent;Adult;Age;Appearance;Binding;Birth;Black race;boys;Breast;California;Cardiovascular Diseases;Caring;Characteristics;Child;Childhood;Chronic;clinical practice;cohort;Color;Communities;Country;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;design;Development;Diabetes Mellitus;Diagnosis;diagnostic criteria;Disparity;early experience;Economics;Electronic Health Record;Endocrine;Endocrinology;Entire hair of pubis;epidemiologic data;Epidemiological trend;ethnic disparity;Ethnic Origin;Ethnic Population;Etiology;evidence base;experience;Follow-Up Studies;Foundations;Future;future pandemic;General Population;Generations;Geography;girls;Health;health equity;health inequalities;Hormones;Incidence;Inequity;infection rate;innovation;Integrated Health Care Systems;Interruption;Intervention;Investigation;Knowledge;Life Cycle Stages;Link;Malignant Neoplasms;marginalization;Measures;Medical;Medical center;medical specialties;member;Menarche;Menstruation;Mental Health;mortality;multi-ethnic;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Outcome;pandemic disease;pandemic impact;pandemic response;physical conditioning;Play;Population;population based;Population Study;post-pandemic;Precocious Puberty;Psychopathology;pubertal timing;Puberty;Publishing;Quasi-experiment;Race;racial difference;racial disparity;racial diversity;racial population;rare condition;Recording of previous events;Reporting;reproductive;Research;Resources;response;Risk;Role;Sample Size;Sampling;segregation;Series;sex;Site;socioeconomics;Structural Racism;Study Subject;Subgroup;Survival Analysis;Techniques;Testis;Time;transition to adulthood;trend;United States

PROJECT_TITLE: Early Puberty During the COVID-19 Pandemic in a Multi-Ethnic, Population-Based Cohort of Children and Adolescents


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Organ Transplantation;Precision Medicine;Prevention;Transplantation

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Our overarching aim is to use multi-omics profiling, which spans genomics, transcriptomics, proteomics and metabolomics profiling of biospecimens collected at prospective timepoints from cardiac patient’s post-transplantation, for discovery and validation of prognostic and diagnostic biomarkers of post-transplantation complications. We utilize existing whole transcriptomics of endomyocardial biopsies (EMBs) and formalin fixed paraffin embedded (FFPE) EMBs, to discover and validate diagnostic and prognostic signatures of acute rejection. We will also leverage genomic, RNAseq, protein and metabolite datasets from equivalent blood timepoints from additional prospectively collected samples to validate these biological findings.

PI_NAMEs: DENG, MARIO C.;KEATING, BRENDAN JAMES (contact);PIENING, BRIAN DONALD;SNYDER, MICHAEL P.

PROGRAM_OFFICER_NAME: ROBIEN, MARK ANDREW

PROJECT_TERMS: Acute;Allogenic;allograft rejection;Allografting;antibody-mediated rejection;Autoantibodies;Biological;Biological Markers;Biology;biomarker discovery;biomarker validation;Biopsy;Biopsy Specimen;Blood;Cardiac;Chronic;Classification;Clinical;Clinical Trials;clinically relevant;cohort;comorbidity;Complex;cost;Data;data integration;data registry;Data Set;Development;Diagnosis;Diagnostic;diagnostic biomarker;diagnostic signature;Disease;Electronic Health Record;Evaluation;Event;exome sequencing;Failure;Formalin;Freezing;Genetic;genetic architecture;Genetic Polymorphism;genetic variant;Genome;genome wide association study;genome-wide;Genomics;Genotype;Heart;heart allograft;Heart Transplantation;high risk;Histocompatibility;Histologic;Histology;Histopathology;Immune;Immune response;immunoreaction;improved;improved outcome;Individual;insight;Interobserver Variability;Knowledge;Maps;metabolomics;minimally invasive;Minor;Minor Histocompatibility Antigens;Molecular;Molecular Diagnosis;molecular marker;multiple omics;Nature;novel;novel diagnostics;Organ;Outcome;Paraffin Embedding;patient population;Patients;Peptides;Phenotype;Physiology;Plasma;post-transplant;precision medicine;prevent;Procedures;Process;Prognosis;prognostic;Prognostic Marker;prognostic signature;prognostication;prospective;Proteins;Proteomics;Research Personnel;Risk;RNA;Sampling;Sensitivity and Specificity;Site;Solid;standard of care;Standardization;study population;Survival Rate;Symptoms;Technology;Testing;Therapeutic immunosuppression;Time;Tissue Embedding;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics;Transplant Recipients;Transplantation;Validation;Variant;Vascular Diseases

PROJECT_TITLE: Multi-omic Biomarker Discovery and Validation in Heart Transplant Patient Populations

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Shigella flexneri is a major source of diarrheal illness with severity of illness being directly related to the ability of S. flexneri to spread intercellularly between monolayers of intestinal epithelial cells within the colon. Whereas the major steps of intercellular spread are known, the bacterial-host interactions that occur, which allow S. flexneri intracellular passage from one cell to an adjacent cell are not well understood. This proposal aims to define the molecular mechanisms for how Synaptopodin promotes S. flexneri intercellular spread thereby increasing severity of diarrheal illness.

PI_NAMEs: HAMILTON, DESMOND J (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: 5 year old;Actin-Binding Protein;Actins;Amino Acids;Bacteria;Cartoons;Cause of Death;Cell Line;Cell membrane;Cells;Child;Colon;Communicable Diseases;Complex;Cytoskeleton;Cytosol;Data;Detection;Development;Diarrhea;diarrheal disease;Disease;Epithelial Cells;Epithelium;F-Actin;Fiber;Fluorescence Microscopy;Immune;Immunoprecipitation;Infection;insight;intestinal epithelium;Intestines;Invaded;Investigation;knock-down;Knowledge;Long term disability;Mass Spectrum Analysis;Membrane;Microfilaments;mimetics;Modification;Molecular;monolayer;Motility;mutant;Mutation;Nutrient;pathogen;Pathogenesis;pathogenic bacteria;Phenotype;Phosphorylation;Plaque Assay;Polymers;Positioning Attribute;Post-Translational Protein Processing;Process;protein function;Proteins;Proteomics;recruit;Role;Severities;Severity of illness;Shigella;Shigella flexneri;Shigella Infections;Site;Source;Structure;synaptopodin;Tail;Testing;Tight Junctions;Tissues;Vacuole

PROJECT_TITLE: Synaptopodin and its role in Shigella flexneri intercellular spread

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE Hyperphosphorylated tau (ptau), a precursor to neurofibrillary tangles, one of the two hallmark pathologies in Alzheimer’s disease (AD), is found in the locus coeruleus (LC) prior to any other brain region. The purpose of this research is to determine how ptau affects the function of LC neurons and spreads from the LC to forebrain regions important for learning and memory. Understanding the role of the LC in AD may lead to new treatment strategies, reducing the burden of AD on individuals and society.

PI_NAMEs: TISH, MARGARET  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: 3-Dimensional;Address;Affect;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease diagnostic;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;American;Amyloid beta-Protein;Architecture;Area;Arousal;Attention;Autopsy;biological adaptation to stress;Brain;Brain region;Calcium;Catecholamines;Cell Culture Techniques;Cell Nucleus;Cells;Clinical Trials;Dementia;Development;Disease;disease model;Epilepsy;experimental study;Functional disorder;Generations;Goals;Health;Human;human imaging;human induced pluripotent stem cells;human model;human tissue;Hybrids;hyperphosphorylated tau;Image;imaging study;Impaired cognition;Impairment;in vivo;Individual;insight;Learning;locus ceruleus structure;Mediating;Memory;Memory Loss;Midbrain structure;model development;Modeling;Mood Disorders;Mus;Nerve Degeneration;nerve supply;Neurobiology;Neurofibrillary Tangles;neuromelanin;neuron loss;Neurons;neuropathology;Neurotransmitters;noradrenergic;Norepinephrine;novel;novel therapeutic intervention;novel therapeutics;Organ;Organoids;Pathologic;Pathology;Patients;Pattern;Pigments;Predisposition;Property;Prosencephalon;Protocols documentation;Research;Resistance;Resources;Rodent;Rodent Model;Role;Schizophrenia;Senile Plaques;sensor;Sleep Disorders;Societies;Source;species difference;Specific qualifier value;stem;Structure;Symptoms;tau aggregation;tau mutation;tau Proteins;Testing;Time;transcriptome;Transgenic Organisms;transmission process;Work

PROJECT_TITLE: A human organoid approach to understanding the role of the locus coeruleus in Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: Project Narrative Inflammation is ubiquitous in all damage and disease in the central nervous system. Astrocytes in the brain and spinal cord become reactive in response to inflammation, losing key homeostatic functions and gaining harmful functions which may contribute to the progression of neurological disease and degeneration. While previously thought to be a homogenous response, our preliminary data indicates striking brain region differences in inflammatory astrocyte reactivity, and the proposed research will investigate the significance of two region-specific reactive astrocyte factors in neuro-immune interactions, thermoregulation, and behavior.

PI_NAMEs: O'DEA, MICHAEL RYAN (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Acute;Affect;Anorexia;Anti-Inflammatory Agents;Astrocytes;ATAC-seq;Behavior;Behavior monitoring;Binding;Biological Assay;Blood - brain barrier anatomy;Body Temperature;Brain;Brain region;cell motility;cell type;Cells;Central Nervous System;Central Nervous System Diseases;chemokine;conditional knockout;cytokine;Data;diencephalon;Dinoprostone;Disease;Eicosanoids;Endotoxins;Enzymes;experimental study;Fever;Functional disorder;Gene Expression;Genetic Transcription;Goals;Growth Factor Inhibition;Heterogeneity;HGF gene;Hypothalamic structure;Immune;Immune system;Immunologics;Implant;In Situ;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Injections;Injury;insight;Intercellular Fluid;intraperitoneal;Intraperitoneal Injections;Knock-out;knockout animal;Knockout Mice;lipid mediator;lipidomics;Lipopolysaccharides;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Mediator;MET gene;Metabolic;Microdialysis;Microglia;Morphology;Mus;natural hypothermia;Nerve Degeneration;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;Neuroimmune;neuroinflammation;Neurons;neurotoxic;novel;Oxidoreductase;Pathogenesis;Pathology;Peripheral;Phagocytosis;Phase;Physiologic Thermoregulation;Production;Proliferating;Property;Prosencephalon;Protein Secretion;receptor;Receptor Protein-Tyrosine Kinases;recruit;regional difference;Research;response;Role;Sampling;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Specificity;Spinal Cord;Stroke;synaptogenesis;systemic inflammatory response;Telemetry;Telencephalon;Testing;Therapeutic;therapeutic target;Tissues;transcriptome sequencing;transcriptomics;Traumatic Brain Injury;Treatment Factor;Work

PROJECT_TITLE: Functional interrogation of region-specific reactive astrocyte factors in neuroinflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOLOGY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative We aim to develop Specifically Targeted Anti-Microbial Peptides (STAMPs), where one or more Spn peptides direct the activity of an anti-microbial peptide (AMP) to kill Streptococcus pneumoniae (Spn), a major cause of morbidity and mortality worldwide. Our target peptide will be derived from Spn cell-cell communication peptides and will be linked to an AMP via complementary peptide nucleic acid (PNA) adapters. Conclusion of the work will lead to the production of a set of PNA-STAMPs that may efficiently and specifically kill Spn in planktonic cultures and biofilm; it will also provide a framework for the production of PNA-STAMP libraries to expand therapeutics targeting Spn and Gram-positive bacteria.

PI_NAMEs: HILLER, NATALIA LUISA (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: 2 year old;5 year old;Address;Adopted;Anti-Infective Agents;anti-microbial peptide;Antibiotics;antimicrobial;Architecture;Bacteria;beta-defensin 3;Categories;Cause of Death;Cell Communication;Cells;Cessation of life;Child;chronic infection;Competence;cost;Country;Data;Death Rate;density;design;Development;Disease;Effectiveness;Environment;Exhibits;Goals;Gram-Positive Bacteria;Growth;Health;Human;Human Microbiome;human pathogen;improved;in vitro activity;Inflammation;innovation;Intranasal Administration;intravenous administration;large scale data;Length;Link;Microbial Biofilms;minimal inhibitory concentration;Molecular;Morbidity - disease rate;mortality;mouse model;Multi-Drug Resistance;Mus;novel;Oral;pathogen;pathogenic bacteria;Peptide Library;Peptide Nucleic Acids;Peptides;Persons;Pharmaceutical Preparations;pneumonia model;pneumonia treatment;Production;Pseudomonas;rational design;Resistance;resistant strain;screening;Species Specificity;Specificity;Streptococcus mutans;Streptococcus pneumoniae;targeted treatment;Taxonomy;Technology;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;therapy development;Upper respiratory tract;Work

PROJECT_TITLE: PNA-STAMPs: Versatile, Potent and Targeted Antibiotics

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Genetics;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_DEPT: DENTISTRY

PHR: Project Narrative Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic gammaherpesvirus that's main route of transmission occurs through saliva in the oral cavity. KSHV encodes an immediate early virion-associated tegument protein, that is vital for efficient lytic reactivation and virus production and that we have established interaction with key host transcription factors. Little is known about the importance of this host pathogen interaction, and this proposal will reveal the mechanisms by which an oncogenic virus utilizes host transcription factors to promote its own lytic lifecycle.

PI_NAMEs: PALMER, MARLEY  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Affect;Amino Acids;Anti-viral Agents;Autophagocytosis;Binding;Binding Sites;Biological;Cell Cycle Regulation;Cell Line;Cell Physiology;cell type;Cells;ChIP-seq;Co-Immunoprecipitations;college;Complex;Coupled;Data;Data Set;Dentistry;Deposition;Development;Disease;DNA;Engineering;Environment;Epigenetic Process;Epithelial Cells;Evaluation;Family;Feedback;FHA Domain;Florida;forkhead protein;FOXQ1 gene;Future;gammaherpesvirus;Gene Expression;Genes;Genome;genome-wide;genome-wide analysis;Genomic approach;Herpesviridae Infections;Homologous Gene;Human Herpesvirus 8;Image;Immediate-Early Proteins;Impairment;in silico;Infection;insight;Integration Host Factors;Kaposi Sarcoma;knock-down;Life Cycle Stages;Lymphoma cell;Lytic;lytic gene expression;Lytic Phase;Malignant Neoplasms;Membrane;Mentors;Modeling;mutant;Mutation;novel;Oncogenic;Oncogenic Viruses;oral biology;Oral cavity;oral cavity epithelium;pathogen;Phase;Play;primary effusion lymphoma;Primary Infection;Production;Proteins;Proteomics;Publishing;recruit;Regulation;Research;response;Role;Route;Saliva;Site;skills;small hairpin RNA;targeted treatment;therapeutic target;Training;transcription factor;transcriptome;transcriptome sequencing;Transfection;transmission process;Universities;Vesicle;Viral;Viral Genome;Viral Proteins;Virion;virology;Virus

PROJECT_TITLE: Role of FOXK subfamily in KSHV infection

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Infectious Diseases;Lung;Lung Cancer;Mental Health;Prevention;Rare Diseases;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Human Papillomavirus (HPV) has emerged as a leading factor in the development of head and neck cancer (HNC); despite the more favorable prognosis of HPV positive HNC, patients may experience distinct patterns of psychological distress that contribute to health behaviors (i.e., tobacco and alcohol use) and have a direct bearing on relapse, morbidity, and mortality. However, the lack of knowledge of this relationship in the context of HPV positive HNC is a critical barrier to patient care and psychosocial intervention development. In support of the NCI’s mission of helping people with cancer live longer and healthier lives, results from this study will develop an understanding of the unique psychosocial needs of patients with HPV positive HNC and the association to health behaviors and long-term health outcomes.

PI_NAMEs: FENECH, ALYSSA LORRAINE (contact)

PROJECT_TERMS: Academia;Acceleration;Address;Affect;Alcohol consumption;Anxiety;archived data;Behavior;Behavior Therapy;Behavioral;Blood specimen;cancer diagnosis;cancer recurrence;Cancer Survivor;cancer therapy;career;Cessation of life;Clinical;clinical care;cohort;coping;Data;Development;Diagnosis;Discipline;Distress;Epidemic;Equation;Exhibits;experience;facial disfigurement;Fellowship;Fright;Goals;Growth;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;Health;Health behavior;Health behavior and outcomes;Health behavior change;Health Psychology;HPV-negative head and neck cancer;Human papilloma virus infection;Human Papillomavirus;improved;Incidence;Individual;Individual Differences;individual variation;Knowledge;Malignant Neoplasms;Medical;Mental Depression;Mission;Modeling;Morbidity - disease rate;mortality;National Cancer Institute;Oncology;oral HPV-positive head and neck cancers;Outcome;Parents;Patient Care;Patient Self-Report;Patients;Pattern;Persons;physical symptom;Population;Process;Productivity;Prognosis;prognostic;programs;psychological distress;psychosocial;Psychosocial Assessment and Care;Psychosocial Factor;Quality of life;recruit;Recurrence;Relapse;Research;Research Personnel;Resources;Risk;Risk Factors;Role;Scientific Advances and Accomplishments;Second Primary Cancers;secondary analysis;Secondary to;side effect;skills;substance use;Supportive care;Surveys;survivorship;Symptom Burden;therapy development;Time;Tobacco use;Training;United Kingdom;Work

PROJECT_TITLE: Psychosocial Predictors of Health Behaviors and Outcomes in Patients with Human Papillomavirus (HPV) Positive Head and Neck Cancer


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE  This project will examine data from a trial of transcranial direct current stimulation for the reduction of hallucinations. Stimulation targets the right superior temporal sulcus (rSTS), which plays a causal role in the manifestation of hallucinations and is associated with abnormal audiovisual integration in psychosis syndromes. Analyses will determine the accuracy of stimulation by assessing electrophysiological (EEG) biomarkers of audiovisual integration, and the efficacy of the intervention by examining clinical measures of hallucination frequency and severity.

PI_NAMEs: TROTTI, REBEKAH  (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Acute;Anodes;Auditory;Auditory Hallucination;auditory stimulus;Behavior assessment;behavior measurement;Behavioral;Biological Markers;Brain;career;Cephalic;Clinical;clinical efficacy;Clinical Trials;Data;Development;Disability outcome;Disease;Disease Outcome;Distress;Double-Blind Method;Electric Stimulation;Electroencephalography;Electrophysiology (science);experience;Fellowship;follow-up;Frequencies;Hallucinations;improved;Intervention;Israel;Learning;Lesion;Literature;Location;Maps;Measurement;Measures;Medical center;Membrane Potentials;Mental disorders;Methods;Modeling;multisensory;neural;neural circuit;neural correlate;neural stimulation;Neuroanatomy;neuroimaging;Neurologic;Neurosciences Research;Noise;noninvasive brain stimulation;novel;novel strategies;Paper;Participant;Patient Self-Report;Patients;Persons;Phase;Play;Predisposition;Production;Psychiatric therapeutic procedure;psychologic;Psychoses;Psychotic Disorders;psychotic symptoms;Publishing;Ramp;Randomized;Research;research clinical testing;Research Personnel;Research Proposals;Resistance;response;Role;Schizophrenia;Sensory Hallucinations;Severities;Signal Transduction;skills;somatosensory;Structure;Structure of superior temporal sulcus;Supervision;Symptoms;Syndrome;targeted biomarker;Techniques;Testing;tool;Training;transcranial direct current stimulation;translational neuroscience;treatment duration;Treatment Efficacy;Treatment Protocols;Visual;Visual Hallucination;visual stimulus;Work

PROJECT_TITLE: A data-driven framework for mapping transcranial electrical stimulation effects on audiovisual integration and hallucinations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: PROJECT NARRATIVE Children who grow up in disadvantaged neighborhoods because of structural racism experience pervasive health and developmental inequities. Suboptimal sleep health may be a pathway through which neighborhood environments lead to poor child health, but this is not well understood, especially among young children (3-5 years). By using novel Geographic Information Science methods to describe neighborhood environments (neighborhood disorder, greenspace), results of this study will provide critical insight to inform future community and family-level interventions and policy to reduce health inequities related to structural racism.

PI_NAMEs: SCHEIBNER, HANNAH ROSE (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: actigraphy;Address;Adolescent;Adult;Age;aged;assault;Attention;Black race;Cardiometabolic Disease;career;Censuses;Characteristics;Child;Child Health;childhood adversity;Communities;community violence;Connecticut;Crime;Critical Race Theory;Cross-Sectional Studies;Data;design;Deterioration;Development;Disadvantaged;Discipline of Nursing;Disease;Disparity;early childhood;Environment;Equity;experience;Exposure to;Family;Feeling;fighting;Fostering;Foundations;Funding;Future;Genetic Code;Geographic Locations;Geography;Green space;Growth and Development function;Health;health equity;health equity promotion;health inequalities;Health Promotion;Home;Housing;improved;Individual;Inequity;Information Sciences;innovation;insight;Intervention;Knowledge;Lead;Life;life span;Light;Link;low socioeconomic status;Malignant Neoplasms;Marketing;Measures;Memory impairment;Mental Health;Mentorship;Methods;Minority Groups;minority health;Modeling;neighborhood disadvantage;neighborhood safety;Neighborhoods;next generation;Noise;novel;novel strategies;Nursery Schools;Obesity;Outcome;Parents;Pathway interactions;physical conditioning;Physical environment;Policies;poor sleep;Predisposition;Preschool Child;protective factors;Publishing;racial diversity;rapid growth;Reporting;Research;resilience;Risk Factors;robbery;Safety;Sampling;School-Age Population;Science;secondary analysis;segregation;Sleep;sleep health;sleep quality;social;Social Characteristics;social cohesion;Social Environment;social health determinants;solidarity;stem;Structural Racism;Training;Trees;United States;Violence;walkability;weapons;Work;Wrist

PROJECT_TITLE: Examining Effects of Disadvantaged and Equitable Neighborhoods on Sleep in Young Children

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (89)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Hearing Loss;Neurosciences;Rehabilitation

PHR: Project Narrative Cochlear implants effectively restore hearing, but their efficacy diminishes with age due to adults having less neural plasticity than children. Research shows that dark exposure in adult mice can renew auditory plasticity, with corticothalamic neurons in the auditory cortex potentially playing a key role. Therefore, understanding the impact of dark exposure on these neurons could improve hearing loss treatments in adults and provide insights into the brain's adaptation to significant input loss, like in stroke and neurodegenerative diseases.

PI_NAMEs: COLLINS, ANTHONY TYRONE (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acute;Address;Adult;Age;age related;Area;Auditory;Auditory area;auditory processing;Auditory system;auditory thalamus;Axon;Biological;Brain;Cell Nucleus;Cells;Child;Closure by clamp;Cochlear Implants;Cognitive;Color;Communication difficulty;Darkness;deafness;Development;Diabetes Mellitus;Education;Electrophysiology (science);experience;Face;Feedback;Geniculate body structure;Hearing;hearing impairment;hearing loss treatment;hearing restoration;hippocampal pyramidal neuron;Impairment;implantation;improved;Individual;injury recovery;insight;Interneurons;Laboratories;Lasers;Malignant Neoplasms;Mental Health;Modality;Mus;neural prosthesis;Neurodegenerative Disorders;Neuronal Plasticity;Neurons;optogenetics;Output;Parvalbumins;Persons;Play;presynaptic;Property;Pyramidal Cells;recruit;Reporting;Research;response;restoration;Risk;Role;Safety;Scanning;Sensory;sensory cortex;sensory gating;Sensory impairment;sensory input;Signal Transduction;Slice;social;sound;Stroke;success;Synapses;synaptic inhibition;Synaptic Transmission;Testing;Thalamic structure;Time;United States;Vision;Visual Cortex;visual deprivation;Visually Impaired Persons

PROJECT_TITLE: Plasticity of Layer 6 corticothalamic pyramidal cell circuits in the adult primary auditory cortex following visual deprivation

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (13)]


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE Despite the pneumococcus being an opportunistic mucosal pathogen, there has been limited investigation into pneumococcus-mucus interactions. Utilizing commercially available mucin that is similar to human MUC5AC, the most abundant mucin in the respiratory tract, I observed that mucin inhibits LytA-mediated autolysis and promotes long-term pneumococcal stationary phase survival, underscoring the importance of understanding the host-pathogen interactions in the mucosa. Completion of the research outlined in this proposal will establish an in vitro model to provide insight into how mucin prolongs pneumococcal stationary phase survival; this phenotype is common in biofilms that are necessary for nasal passage colonization and are notoriously difficult to treat with traditional antibiotic therapy.

PI_NAMEs: JOHNSON, CYDNEY N (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: airway epithelium;amidase;Antibiotic Therapy;Antibiotics;Area;Autolysin;Autolysis;Bacteria;bacterial genetics;Bacterial Physiology;beta-Lactams;Biochemical;Bioinformatics;Biological Assay;Biology;Bronchitis;Carbon;career development;Cause of Death;Cell Culture Techniques;Cell Death;Cell Wall;Cells;Cessation of life;Child;clinically relevant;Collaborations;community acquired pneumonia;Cues;Cytolysis;Cytoplasm;cytotoxicity;Data;Data Set;Disease;Environment;Epithelium;Escalator;Future;Gases;Gel;Genes;Genetic;Genetic Determinism;Goals;Gram-Positive Cocci;Growth;host colonization;Human;Hydrolysis;In Vitro;in vitro Model;in vivo;in vivo Model;Infection;Infection prevention;Inflammation;Inflammatory Response;Innate Immune System;insight;Investigation;Labyrinth;Lower Respiratory Tract Infection;Lower respiratory tract structure;Lung;macromolecule;Mediating;Metabolic;microbial;Microbial Biofilms;Modeling;Modernization;Molecular Weight;MUC5AC gene;Mucins;Mucous body substance;Mucous Membrane;Mus;Nasopharynx;Neuraminidase;Nitrogen;Nose;Nutrient;Nutritional;pathogen;Pathogenicity;Pathway interactions;Peptidoglycan;Phase;Phenotype;Physiological;Physiology;Pneumococcal Colonization;Pneumonia;pneumonia treatment;prevent;Process;Protein Glycosylation;Publishing;Reporting;Research;Respiratory System;Scientist;Serotyping;Source;Specificity;Streptococcus pneumoniae;Streptococcus pneumoniae plY protein;therapeutic development;therapy design;Tissues;tool;Toxic effect;Training;transposon sequencing;Vaccines;Virulence;Viscosity;Water;World Health Organization

PROJECT_TITLE: Mucin inhibits pneumococcal stationary phase autolysis


NIH_SPENDING_CATS: Contraception/Reproduction;Neurosciences;Pregnancy;Sleep Research;Women's Health Research

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative Pregnancy is a particularly vulnerable state in which inadequate sleep is linked to negative health outcomes, and this might explain why women are reported to sleep more during their first trimester of pregnancy. I developed a novel paradigm in Drosophila melanogaster to model increased sleep drive during gravidity with the goal of understanding its causes and consequences. Further, studying the mechanisms that drive this form of increased sleep need will provide a potential avenue for studying how sleep need is measured, regulated, and fulfilled in general, as is my long term goal as a career scientist.

PI_NAMEs: GLANTZ, ETHAN  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Address;Animal Model;Behavioral;Binding;Biological Models;Calcium;career;Cessation of life;Child;Communication;Compensation;cost;Data;Development;Drosophila genus;Drosophila melanogaster;Drowsiness;early pregnancy;Ensure;experience;Female;First Pregnancy Trimester;fluorescence imaging;fly;Foundations;Future;Goals;Gravid;Gravidity;gut health;Health;health of the mother;Health protection;Homeostasis;hormonal signals;Human;Hypersomnolence;Individual;insight;knowledge base;Life;Link;Longevity;male;Measures;Mechanics;Mentors;Mentorship;Methods;Modeling;Mothers;Mus;Nervous System;neural circuit;Neurons;novel;offspring;Outcome;Partner in relationship;Pathway interactions;Peptides;Physiological;poor sleep;Population;Predisposition;Pregnancy;pregnant;premature;Prevalence;prevent;Public Health;Reporter;Reporting;Reproduction;reproductive;reproductive function;Reproductive Health;Research;Research Personnel;Research Proposals;Risk;Role;Scientist;sex;Signal Transduction;Sleep;Sleep Deprivation;sleep regulation;Sleeplessness;sperm cell;System;Technical Expertise;Testing;Time;Training;voltage;Woman;Women's Health;Work;zygote

PROJECT_TITLE: Using a novel model system to explore the causes and consequences of altered sleep need during pregnancy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative This proposal requests support for participation of early career investigators, women, and underrepresented minorities in the 2024 Biomineralization GRC and GRS allowing them to interact with established investigators in the field. This international conference will provide new insight into common genetic, biochemical, and cellular mechanisms of the biological processes involved in mineralized tissue formation in model organisms. Such understanding will enhance the capabilities to diagnose and treat mineralization related diseases that result from disorders in bone and teeth development and the unwanted formation of minerals in other tissues.

PI_NAMEs: ESTROFF, LARA A (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Affect;aging population;Amelogenesis Imperfecta;Aortic Valve Stenosis;Area;Atherosclerosis;Bacteria;Biochemical;Biochemical Process;Biocompatible Materials;Biological Models;Biological Process;biological systems;Biology;Biomechanics;biomineralization;Biophysical Process;bone;Bone necrosis;Breast Microcalcification;Calcium Carbonate;calcium phosphate;Carbonates;career;Chemicals;Chemistry;Communities;Complement;Complex;Dental;Dental caries;Dental Enamel;Dental Prosthesis;Dentin;Dentistry;Deposition;design;Development;developmental disease;Diagnosis;Disabled Persons;Discipline;Disease;Early Diagnosis;Elements;empowerment;Engineering;Environment;Environmental Science;Event;Female;Fostering;Genetic;Genetic Diseases;Geology;Germany;graduate student;Growth;Health;Homeostasis;Hour;Human;improved;In Vitro;in vivo Model;Industrialization;innovation;inorganic phosphate;insight;International;Invertebrates;Ion Transport;iron oxide;Jaw;Life;Malignant Neoplasms;mechanical properties;Medicine;meetings;mineralization;Minerals;minimally invasive;Minority;model organism;Morbidity - disease rate;multidisciplinary;novel;Oral;Organism;Osteogenesis Imperfecta;Osteoporosis;Pathologic;Pathology;Performance;Phase;physical property;Physics;Physiological;Postdoctoral Fellow;posters;preservation;Prevalence;Prevention approach;Process;programs;Prokaryotic Cells;Property;Quality of life;Request for Proposals;Research;Research Personnel;Scientist;Sea Urchins;self assembly;Silicon Dioxide;Structure;symposium;System;Technology;Time;Tissues;Tooth structure;Translating;Translational Research;Trees;Underrepresented Minority;Underrepresented Populations;Universities;urolithiasis;Vertebrates;Woman

PROJECT_TITLE: 2024 Biomineralization Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 JC (11)]


NIH_SPENDING_CATS: Autoimmune Disease;Dietary Supplements;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Natural Products;Nutrition;Obesity

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative  Dysregulation of indole and phenol metabolite production by the gut microbiome is linked with many diseases. Increasing circulating concentrations of indole or phenol metabolites has shown promise in ameliorating inflammatory bowel disease or obesity in mouse models, respectively, but there are not currently methods to increase gut microbiome production of these important metabolite. This proposal aims to define the relationship between diet and production of indole and phenol metabolites, with the eventual goal to create dietary formulations to help treat microbiome-related diseases such as inflammatory bowel disease and obesity.

PI_NAMEs: ABUSALIM, JENNA  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: 16S ribosomal RNA sequencing;absorption;Affect;Amino Acids;aryl hydrocarbon receptor ligand;Automobile Driving;Bacteria;Biological Response Modifiers;Cellulose;cinnamic acid;Colon;cooking;Data;Diet;Diet Modification;dietary;Dietary Component;dietary control;Dietary Fiber;Dietary Formulations;Dietary intake;Dietary Proteins;Digestion;Disease;Equilibrium;Feces;feeding;Fermentation;Fiber;Food Processing;Foundations;gastrointestinal epithelium;Goals;gut microbiome;gut microbiota;Hippuric acid;histological stains;Homeostasis;Hour;Immune Tolerance;Indoles;Inflammatory Bowel Diseases;Infusion procedures;Intestines;Inulin;Isotopes;Label;Link;liquid chromatography mass spectrometry;Measures;Mechanics;Mediating;Metabolism;Methods;microbial;microbial composition;microbiome;microbiome composition;mouse model;Mucins;Mucous body substance;Mus;Obesity;obesogenic;Patients;Pectins;Phenols;Phenylalanine;Physiological;Physiology;Process;Production;protein aggregation;Protein Denaturation;Protein Secretion;Proteins;Route;Scheme;Serum;Small Intestines;Source;stool sample;Techniques;Testing;Thick;tool;Tryptophan;Work

PROJECT_TITLE: Dissecting the effect of diet on gut microbiome metabolism

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE Ion channels are membrane proteins that allow ions to flow across cell membranes, the basis of electrical signaling. Their precise function is of great importance, and dysfunction in calcium-activated potassium channels in particular has been associated with many pathophysiological conditions, such as hypertension, asthma, renal malfunction, various cognitive impairments, epilepsy, sleep disorders, and Alzheimer’s disease, making these channels excellent drug targets for these conditions. The proposed studies investigate the molecular mechanism by which lipids modulate channel gating and inactivation, whose understanding can have major therapeutic consequences.

PI_NAMEs: NIMIGEAN, CRINA M (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Affect;Alzheimer's Disease;Asthma;Binding;Biological Assay;Calcium;Calcium Binding;Calcium-Activated Potassium Channel;Cell membrane;Cells;Charge;circadian regulation;Circadian Rhythms;Complex;Computer Analysis;Cryoelectron Microscopy;Defect;Dependence;Detergents;Disease;Drug Targeting;Electrophysiology (science);Electrostatics;Endowment;Epilepsy;Functional disorder;Goals;Grant;Hearing;Homologous Gene;Human;Hypertension;Impaired cognition;Investigation;Ion Channel;Ions;Kidney;large-conductance calcium-activated potassium channels;Length;Letters;Ligands;Lipid Bilayers;Lipids;Liposomes;Maintenance;Measures;Mechanical Stress;Membrane;Membrane Lipids;Membrane Potentials;Membrane Proteins;Molecular;Muscle Tonus;Mutagenesis;N-terminal;nanodisk;neurotransmitter release;Neutralization Tests;Organism;particle;Peptides;Phenotype;Physiological;Physiological Processes;Physiology;Play;Potassium;Potassium Channel;Property;Publishing;reconstitution;response;Role;screening;Shaker potassium channel;Signal Transduction;simulation;Sleep Disorders;Sodium Chloride;Stimulus;Structure;success;System;Testing;Therapeutic;therapy design;Thick;Thinness;Tissues;Transmembrane Domain;Variant;Vascular Smooth Muscle

PROJECT_TITLE: Molecular Mechanisms of Potassium Channel Permeation and Gating

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-K (02)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: PROJECT NARRATIVE Climate change, exacerbated by urbanization, is escalating extreme heat events globally, posing significant threats to human health. This longitudinal pilot study based in Miami, Florida investigates the effects of local heat exposure among vulnerable populations, specifically on maternal and pregnancy health, and women’s adaptive behaviors. By analyzing hyperlocal heat assessments and interactions with SDoH, this research aims to inform effective and equitable adaptations to mitigate the risks of heat during pregnancy.

PI_NAMEs: RAMIREZ, JAZMIN  (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Adaptive Behaviors;Address;Adopted;Adoption;adverse pregnancy outcome;Affect;Air Conditioning;Award;Behavior;career;Censuses;Child;Cities;Climate;climate change;climate-related health;cohort;Color;Communities;Community Health;Complex;Congenital Abnormality;County;Dangerousness;Data;Diabetes Mellitus;Disease;Economics;Epidemiology;Equity;Event;Exercise;experience;Exposure to;extreme heat;Fellowship;Florida;Fostering;Future;Health;Health behavior;health equity;Health Hazards;Heat Exhaustion;Home;hospital admission rate;Housing;Human;Humidity;Hypertension;Immigrant;indexing;indigenous community;Individual;interest;Intervention;Knowledge;lens;Link;lonely individuals;Low Birth Weight Infant;Low income;Manuscripts;Maternal Health;maternal outcome;Measurement;Mentors;National Institute of Nursing Research;Neighborhoods;Nurses;Nursing Research;Outcome;Pattern;Persons;Physiologic tolerance;Pilot Projects;Policies;Population;Postdoctoral Fellow;Pregnancy;pregnancy health;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;programs;Psychological Stress;Records;Research;Research Personnel;Risk;risk mitigation;Role;Services;skills;social determinants;social health determinants;Social isolation;stillbirth;Strategic Planning;systematic review;Temperature;Urbanization;Vulnerable Populations;Weather;Well in self;Woman;Work

PROJECT_TITLE: Effects of Heat Exposure on Maternal and Pregnancy Health: Understanding the Role of Social Determinants and Adaptive Behaviors


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is a debilitating and irreversible neurodegenerative disease associated with major disruptions to memory. While memories are thought to be stored in engrams, or ensembles of neurons throughout the brain that are necessary and sufficient for memory expression, it is unknown what biophysical changes occur in these individual engram cells and whether their disruption drives AD-associated memory loss. Here, I will identify and manipulate molecular signatures unique to engram cells in the hippocampus (Aim 1) and assess how these signatures are altered in a mouse model of AD (Aim 2) in order to identify novel molecular targets for AD-associated memory loss.

PI_NAMEs: BULTHUIS, NICHOLAS EDWARD (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: 4-Hydroxy-Tamoxifen;Address;Age;age related changes;age related neurodegeneration;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease model;APP-PS1;Behavioral Paradigm;Bioinformatics;Biophysics;Brain;Breeding;career;Cell Nucleus;Cells;cohort;conditioned fear;dentate gyrus;design;differential expression;Disease;Disease Progression;Dissociation;Engineering;Environment;Euthanasia;Exhibits;experimental study;Exposure to;Flow Cytometry;Fluorescent in Situ Hybridization;Fostering;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Markers;genetic signature;Green Fluorescent Proteins;Hippocampus;Immediate-Early Genes;Impairment;in silico;In Situ Hybridization;Individual;knock-down;Knowledge;Label;Mediating;Memory;memory encoding;Memory impairment;Memory Loss;memory retrieval;Mentors;Molecular;Molecular Profiling;Molecular Target;mouse model;Mouse Protein;Mus;neural;Neurobiology;Neurodegenerative Disorders;Neurons;novel;Nuclear;Nuclear RNA;Operative Surgical Procedures;Oral;Performance;Play;Process;promoter;Reporter;Reporting;Research;Research Personnel;Resolution;Retrieval;RNA Interference;Role;Sampling;single nucleus RNA-sequencing;skills;Sorting;Symptoms;Technical Expertise;Techniques;Testing;therapeutic target;Time;Tissues;Training;Transcript;transcriptome;transcriptome sequencing;Transgenic Organisms;Viral;Writing

PROJECT_TITLE: The impact of Alzheimer's disease on novel genetic signatures of hippocampal memory traces


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative  Breast cancer is the most diagnosed cancer worldwide, accounting for an estimated 12% of all cancer cases in 2020, with promising noninvasive treatments under active development. This proposal aims to develop physics-informed machine learning and magnetic resonance imaging techniques for evaluating noninvasive focused ultrasound treatments for breast cancer. Development of these techniques will provide efficient breast MRI exams for clinical use, support the collection of images to evaluate focused ultrasound breast cancer treatments, and advance current understanding of applying machine learning models to magnetic resonance imaging.

PI_NAMEs: ADAMS, SAMUEL IAN (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Adoption;anti-cancer research;Architecture;Biological;biomarker development;Biomedical Engineering;biomedical imaging;Breast;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;breast imaging;Breast Magnetic Resonance Imaging;cancer clinical trial;cancer diagnosis;career;chemical property;Clinical;clinical care;clinical decision-making;clinical examination;clinical translation;Collection;Comprehension;computerized data processing;coping;cost;Data;Data Set;deep learning;deep learning model;design;Development;Diagnostic radiologic examination;Diffusion;Engineering;Enrollment;Environment;Evaluation;Evolution;Face;Focused Ultrasound;Focused Ultrasound Therapy;Foundations;Future;Goals;healthy volunteer;Image;Imaging Techniques;insight;interest;Intervention;Interventional Imaging;Interventional radiology;Knowledge;Learning;Machine Learning;machine learning model;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Measurement;Measures;Medical Imaging;Mentors;Mentorship;minimally invasive;Modeling;Modernization;Monitor;multidisciplinary;Nature;neural network;neural network architecture;non-invasive imaging;Oncology;Pathway interactions;Performance;physical model;physical property;Physics;Problem Solving;Procedures;Property;Protocols documentation;radiologist;reconstruction;Relaxation;Research;Resources;scientific computing;Signal Transduction;skill acquisition;soft tissue;Standardization;System;Technical Expertise;technique development;Techniques;temporal measurement;Testing;Therapeutic;Time;Tissues;tool;Training;training data;Translations;Uncertainty;Universities;usability;Utah;Validation;Variant;Work

PROJECT_TITLE: Quantitative magnetic resonance imaging for non-invasive breast cancer therapy using physics-informed neural networks.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-B (20)]


ORG_CITY: Nashville

ORG_DEPT: PATHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Individual heterogeneity in progression to type 1 diabetes (T1D) complicates clinical trial enrollment and evaluation. To address this, we will focus on how anti-insulin B lymphocytes, a key player in T1D pathogenesis, acquire the ability to recognize insulin, and how this changes with T1D progression. Completion of these studies will elucidate the influence of somatic hypermutation on insulin affinity and polyreactivity for other antigens, to support future studies that track these changes to predict T1D progression or immunotherapy response.

PI_NAMEs: BASS, LINDSAY EMMA (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Affinity;Amino Acids;Antibodies;Antibody Binding Sites;Antigens;Area Under Curve;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Automobile Driving;autoreactive B cell;B-Cell Antigen Receptor;B-Cell Receptor Binding;B-Lymphocytes;Back;Binding;biobank;career;Cells;Clinical;Clinical Management;clinical trial enrollment;Clinical Trials;cohort;Complications of Diabetes Mellitus;computational pipelines;Cross-Sectional Studies;Custom;Data;design;Development;Diabetes Mellitus;diabetes pathogenesis;Disease;Disease Progression;DNA;Drops;Epitope Mapping;Epitopes;Evaluation;Evolution;Exhibits;experimental study;Future;Germ Lines;Goals;Heterogeneity;Human;Hybridomas;Immune;Immune Tolerance;Immunoglobulin Somatic Hypermutation;Immunotherapy;impaired glucose tolerance;improved;Individual;individual variation;Inflammation;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;islet cell antibody;Knowledge;Link;Lymphocyte;Measures;Mentorship;Molecular;Monitor;mouse model;multidisciplinary;Mus;Mutate;Mutation;oral glucose tolerance;Outcome;Participant;Pathology;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Play;progression risk;Recombinants;response;Risk;Role;Sampling;Scientist;seroconversion;Serum;single cell technology;Specificity;Structure;Symptoms;T-Lymphocyte;Technical Expertise;Technology;Testing;Time;Training;Variant

PROJECT_TITLE: Evolution of B Lymphocyte Insulin Autoantigen Recognition in Type 1 Diabetes

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: NARRATIVE Exposure to early life adversity, such as neglect or abuse, is a major risk factor for developing neuropsychiatric disorders. Although symptoms of these conditions often arise during adolescence, most studies have focused on brain and behavioral changes in adults. This project will instead uncover how early life experiences alter the trajectory of brain development and identify sensitive windows for therapeutics that can be used to prevent or treat mental health disorders in at-risk populations.

PI_NAMEs: GOODPASTER, CAITLIN  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Acute;Adolescence;Adolescent;adolescent brain development;Adult;Amygdaloid structure;Anxiety;Anxiety Disorders;avoidance behavior;Beds;Behavior;Behavioral;Biological;Biological Assay;Brain;Brain region;Caring;Cells;Childhood;Chronic;Cognition;conditioned fear;Development;early experience;early life adversity;early life stress;effective intervention;emerging adult;Emotional;Emotions;Environment;Evolution;Exhibits;experience;experimental study;Exposure to;Fiber;Fluorescence Microscopy;foot;Functional disorder;Genetic;genetic approach;Genetic Risk;Individual;insight;Knowledge;Label;Learning;Life;Life Experience;Light;Link;maltreatment;Maps;Measures;Mediating;Mental Depression;Mental disorders;Mental Health;Modeling;Mood Disorders;Mus;National Institute of Mental Health;neglect;neural circuit;Neurobiology;Neurons;neuropsychiatric disorder;Neurosciences;Optics;optogenetics;Outcome;Pattern;Phobias;Photometry;Pilot Projects;Populations at Risk;Positioning Attribute;postnatal;postnatal development;prevent;Process;programs;Protocols documentation;psychiatric symptom;Recording of previous events;Research;Resources;response;Rewards;Risk Factors;Risk Taking;Safety;Shock;Stress;Symptoms;Synapses;System;Testing;Therapeutic;Tissues;Training;virus genetics;Work

PROJECT_TITLE: Investigating the effects of early life adversity on the developmental trajectory of avoidance circuitry

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Lymphatic Research;Pneumonia and Influenza

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: NARRATIVE The lymphatic system is central in the immune response to both infectious and non-infectious stimuli, yet little is known about the diverse interactions between the immune cells and lymphatic endothelium during infection. My project examines the role of lymphatic endothelial cell signaling through sphingosine-1-phosphate receptor 1 in influenza infection. These studies will provide novel insights into the interactions between immune cells and the lymphatic vessels during infection and inform therapeutic development.

PI_NAMEs: LABOMBARDE, JOCELYN  (contact)

PROJECT_TERMS: acute infection;adaptive immune response;angiogenesis;Antibodies;Antibody Formation;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Architecture;Autoimmune Diseases;B-Lymphocyte Subsets;B-Lymphocytes;Blood Flow Cytometry;Body Weight decreased;CD4 Positive T Lymphocytes;cell motility;Cell Physiology;Cells;chemokine;Chronic;Chronic lung disease;Data;Dendritic Cells;density;Development;Disease;Dose;Endothelial Cells;Enzyme-Linked Immunosorbent Assay;experimental study;Flow Cytometry;G-Protein-Coupled Receptors;Gene Dosage;Gene Expression;Generations;Genes;Human;Immune;Immune response;Immunofluorescence Immunologic;Impairment;improved;Infection;Inflammation;Influenza A virus;influenza infection;influenzavirus;Innate Immune Response;insight;KDR gene;Leukocytes;Ligands;LoxP-flanked allele;Lung;lung injury;lymph flow;lymph nodes;Lymphangiogenesis;Lymphatic;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic Endothelium;Lymphatic System;lymphatic vessel;Lymphedema;Lymphocyte;Malignant Neoplasms;Measures;Mediastinal lymph node group;Mediating;Mediator;Memory;Memory B-Lymphocyte;Morbidity - disease rate;mouse model;Multiple Sclerosis;Mus;novel;Organ;pathogen;Pathology;Phenotype;Play;Population;Proteins;receptor;Reporting;Resolution;response;Role;Shapes;Signal Transduction;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Spleen;Stimulus;Structure of germinal center of lymph node;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte Subsets;tertiary lymphoid organ;Testing;therapeutic development;Tissues;trafficking;transcriptome;transcriptome sequencing;Viral;Virus;Weights and Measures

PROJECT_TITLE: The Role of Lymphatic Endothelial Cell- Expressed Sphingosine-1-Phosphate Receptor 1 on Immune Cell Trafficking and Response to Influenza Virus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (20)]


NIH_SPENDING_CATS: Complementary and Integrative Health;Dietary Supplements;Lung;Nutrition;Obesity

ORG_CITY: CHAPEL HILL

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Pulmonary inflammatory diseases, which are exacerbated with obesity, present a significant challenge to public health. This application studies how dietary docosahexaenoic acid (DHA) can lower pulmonary inflammation in the context of obesity. This will ultimately contribute toward improving lung health in individuals with obesity.

PI_NAMEs: VIRK, RAFIA  (contact)

PROJECT_TERMS: Acute Lung Injury;Adult;Alveolar Macrophages;Anti-Inflammatory Agents;Antiinflammatory Effect;Arachidonic Acids;Automobile Driving;Binding;Biochemical;Biological Assay;Biomedical Research;Biophysics;career;Cause of Death;Cell Culture Techniques;Cell membrane;Cells;cellular targeting;chemokine;Cholesterol;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Research;Consumption;COVID-19;cytokine;Data;diet-induced obesity;dietary;Disease;Docosahexaenoic acid supplementation;Docosahexaenoic Acids;Equilibrium;Esterification;Exhibits;experimental study;Fatty Acids;Flow Cytometry;Fostering;Foundations;FPR2 gene;Future;G-Protein-Coupled Receptors;global health;Homeostasis;Hydroxylation;Imaging Device;Imaging Techniques;Immune;Immunoassay;improved;In Vitro;Individual;Inflammation;Inflammatory;inflammatory lung disease;Inflammatory Response;innovation;interdisciplinary collaboration;Knockout Mice;Laboratories;Leadership;Leukotrienes;lipidomics;Lipopolysaccharides;Lung;Lung Diseases;lung health;lung injury;Macrophage;Mass Spectrum Analysis;Measures;Membrane;Membrane Microdomains;Mentors;Methods;Microscopy;Modeling;molecular dynamics;mouse model;Mus;Myelogenous;novel therapeutic intervention;Obese Mice;Obesity;Omega-3 Fatty Acids;Omega-6 Fatty Acids;Persons;Phenotype;Phospholipids;Polyunsaturated Fatty Acids;Population;Predisposition;Property;Prostaglandins;Public Health;Pulmonary Inflammation;receptor;Research;Research Design;Research Proposals;Resolution;respiratory;response;Role;Severities;Signal Transduction;skills;Solid;Sphingolipids;Techniques;Testing;Therapeutic;Writing

PROJECT_TITLE: Reducing Pulmonary Inflammation in Obesity with Docosahexaenoic Acid

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is a newly identified inflammatory and hematologic disease caused by somatic mutations in UBA1. VEXAS syndrome is present in 1/14,000 individuals, confers high mortality, but there is no effective treatment to date. In this project, I propose to define the cellular and molecular mechanisms of inflammatory reactions in this syndrome by using a VEXAS disease mouse model, to improve our understanding of pathogenesis and to propose potential treatments.

PI_NAMEs: SAWAI-FRANTZ, AYANA  (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Affect;Animal Model;Animals;Appearance;autoinflammatory;autoinflammatory diseases;Birth;blastocyst;Blood;Blood Cells;Bone Marrow;Cell Lineage;Cell model;cell type;Cells;conditional knockout;Cytoplasm;design;Development;Diagnosis;Disease;disease model;disease phenotype;Disease Progression;disease-causing mutation;effective therapy;Enzymes;experimental study;Future;Hematological Disease;Hematopoietic;Hematopoietic stem cells;Human;human disease;immunoreaction;Impairment;improved;Individual;induced pluripotent stem cell;Inflammation;Inflammatory;insight;Knock-out;Knockout Mice;Link;LoxP-flanked allele;Lymphoid;Molecular;mortality;mouse model;Multipotent Stem Cells;Mus;mutant;Mutation;Myelogenous;Myeloid Cells;novel;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Persons;Physiological;Physiology;premature;Protein Isoforms;Proteins;Reaction;Reporter;response;Role;Sampling;Severities;Signal Transduction;Somatic Mutation;Specific qualifier value;stem cell population;stem cells;Syndrome;System;systemic inflammatory response;Tamoxifen;Therapeutic;therapeutically effective;Time;Tissues;tool;Transgenic Mice;Translation Initiation;Up-Regulation;Vacuole;Zebrafish

PROJECT_TITLE: Defining the role of Uba1 in bone marrow physiology and inflammation


PHR: Project Narrative Excessive, reduced or inappropriate cell death often lead to inflammation and is frequently found in many diseases. The 2024 Gordon Research Conference and Gordon Research Seminar on Cell Death will provide a platform for unencumbered scientific exchange, focusing on mechanisms that regulate different cell death modalities and how they impact on host-pathogen interactions, inflammatory diseases and cancer. The conference will foster career development of trainees at all levels, accelerate discovery in these areas, and advance new opportunities for therapeutic intervention in cell death-associated illnesses.

PI_NAMEs: MEIER, PASCAL  (contact)

PROGRAM_OFFICER_NAME: BARTELS, ADELINA EWURA-ABENA

PROJECT_TERMS: Academia;Acceleration;Address;Anti-Inflammatory Agents;Area;Atmosphere;cancer therapy;career;career development;Cell Death;Cells;Clinical;Collaborations;Communication;Communities;Complex;Development;Disease;disease diagnosis;experience;Faculty;Fostering;Funding;Goals;Homeostasis;Hour;Immune;immune activation;Immune response;Immune system;Immune System Diseases;Immunity;Industry;Infection;Inflammation;Inflammatory;innovation;International;Knowledge;Lead;Learning;Malignant Neoplasms;meetings;Mentorship;Minority Groups;Modality;novel therapeutics;Oral;Participant;pathogen;Pathologic;peer;Postdoctoral Fellow;posters;prevent;Process;programs;Request for Proposals;Research;Research Personnel;Resolution;Role;Science;Scientist;Senior Scientist;Signal Transduction;Structure;Students;symposium;Therapeutic Intervention;Time;tissue repair;Tissues;Underrepresented Minority;United States;unpublished works;Vocational Guidance;Work

PROJECT_TITLE: 2024 Cell Death Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 CAB-D (M1)]