NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Sleep Research

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE Sleep problems affect up to 93% of individuals with autism spectrum disorder (ASD). These sleep problems can precede an ASD diagnosis and worsen core ASD symptoms. This project will investigate the relationship between early life sleep loss and ASD in a genetic mouse model of ASD to better understand the molecular consequences of sleep loss in order to allow for targeted intervention.

PI_NAMEs: MEDINA, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Adult;Adverse effects;Advisory Committees;Affect;Age;Animal Model;Applied Skills;autism spectrum disorder;autism symptoms;Behavior;Behavioral;beta catenin;Binding;Brain;C-terminal;career;Cell Nucleus;cell type;Cells;Clinical;Cognition;cognitive ability;Cognitive deficits;cognitive function;Data Analyses;Data Set;Development;Diagnosis;Disease;Down-Regulation;Early Intervention;excitatory neuron;experience;falls;Gene Expression;Gene Expression Profile;gene repression;Genes;Genetic;Genetic Models;Genetic Transcription;Genomics;Glutamates;Goals;Human;improved;Individual;individuals with autism spectrum disorder;Infant;insight;Intervention;Knowledge;Learning;Life;Long-Term Effects;member;model of autism spectrum disorder;Molecular;Molecular Abnormality;mouse model;multiple omics;Mus;mutant;Mutation;neurodevelopment;Neurodevelopmental Disorder;Neurosciences;Neurosciences Research;Nuclear;Nuclear RNA;Nuclear Translocation;Pathway interactions;Phase;Phenotype;Polysomnography;poor sleep;Positioning Attribute;Postdoctoral Fellow;postnatal;pre-doctoral;programs;Proteomics;Publishing;Quality of life;Reporting;Repression;Research;Research Institute;Research Project Grants;response;Role;Scaffolding Protein;Siblings;single nucleus RNA-sequencing;skills;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep quality;Sleeplessness;Study models;Synapses;Synaptic plasticity;Syndrome;Technical Expertise;Testing;Training;transcriptome sequencing;transcriptomics;Wild Type Mouse;WNT Signaling Pathway;Work

PROJECT_TITLE: UNDERSTANDING THE CONSEQUENCES OF SLEEP LOSS IN AN AUTISM MOUSE MODEL

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAN JUAN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PUERTO RICO RIO PIEDRAS

ORG_STATE: PR

PHR: The main goal of the NeuroID program is to increase diversity in the Neurosciences by establishing a cohort of interested students that will receive academic and professional training in neuroscience- related research and developmental activities. Specifically, the NeuroID program will be primarily training dedicated Hispanic undergraduate students, which at the end the program will pursue a research career in Neuroscience. The core of the program is a comprehensive research experience for undergraduate students based on an established research-with-purpose training philosophy that integrates research and community outreach activities, to enhance empathy, social responsibility and self-motivation skills. At the end, students will have the necessary research, academic and professional skills to succeed in a research career in neuroscience.

PI_NAMEs: GARCIA-ARRARAS, JOSE E (contact);MALDONADO-VLAAR, CARMEN SARA

PROGRAM_OFFICER_NAME: JONES, MICHELLE

PROJECT_TERMS: academic program;Academic Training;Active Learning;Area;Biology;career;cohort;Community Outreach;Dedications;Development;Educational workshop;Empathy;experience;Fortification;Funding;Gender;Goals;graduate school;Grant;Hispanic;Hispanic Populations;Institution;interest;Island;Knowledge;Laboratories;learning strategy;Mentors;metropolitan;Motivation;Neurobiology;Neurosciences;Neurosciences Research;Oral;Participant;Philosophy;Population;Privatization;programs;Puerto Rico;Race;recruit;Research;Research Personnel;Science;Series;skills;Social Responsibility;Social status;Students;summer research;Training;Training Activity;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Universities;Vocational Guidance;Writing

PROJECT_TITLE: Neuroscience Research Opportunities to Increase Diversity (NeuroID)


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Lung

ORG_CITY: ELLICOTT CITY

ORG_NAME: LINSHOM MEDICAL INC

ORG_STATE: MD

PHR: Project Narrative This SBIR research will demonstrate a superior method of respiratory monitoring that will be first to enable continuous predictive respiratory monitoring (CPRM) at the patient bedside and in the future at the patient’s home. This research (phase 1 and 2) and innovative product research & development (phase 2) will enable commercialization of the Linshom CPRM that will move the entire field of respiratory monitoring from responsive (too late) to predictive, where patient respiratory decline is identified when health care providers can take action and pre-empt patient decline. This will reduce morbidity, mortality and healthcare expense. The engineering research (phase 2) will re-design and miniaturize the sensor technology allowing these developments to be embedded in multiple additional, smaller form factors (i.e. nasal cannula, home use) to reach more patients in need of continuous, predictive respiratory monitoring.

PI_NAMEs: FELDMAN, RONEN  (contact);URMAN, RICHARD D.

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Accident and Emergency department;Acute;Adoption;Adverse event;Apnea;Cannulas;Capnography;Caring;Chronic;Clinical;Clinical Data;Clinical Research;commercialization;Complex;cost;Data;Data Set;design;Detection;Development;Devices;Diagnosis;Discipline of Nursing;Distress;Early Diagnosis;Engineering;Enrollment;Event;Floor;Funding;Future;Goals;Growth;Health Personnel;Healthcare;Healthcare Systems;Home;Hour;Human;improved;innovation;Intensive Care Units;Intervention;Intubation;large scale production;manufacture;Measurement;Measures;Medical;Methods;miniaturize;miniaturized sensor;Monitor;Morbidity - disease rate;mortality;Nose;novel;novel strategies;Operating Rooms;Outcome;Oxygen saturation measurement;Patient Monitoring;Patient Transfer;Patients;Phase;Physiologic pulse;Physiological;portability;Postoperative Period;preempt;prevent;Process;profiles in patients;prototype;Pulse Oximetry;quality assurance;Research;research and development;Respiration;respiratory;Respiratory Failure;Respiratory physiology;response;Savings;Seminal;Sensitivity and Specificity;sensor;sensor technology;Small Business Innovation Research Grant;sound;standard of care;Statistical Data Interpretation;System;Technology;Temperature;Testing;Tidal Volume;Time;tool;tool development;ventilation;Ventilatory Depression;verification and validation

PROJECT_TITLE: Advanced Prediction of Emerging Respiratory Decline with the Linshom Continuous Predictive Respiratory Sensor (CPRS)


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PI_NAMEs: CORNETT, LAWRENCE E (contact)

PROGRAM_OFFICER_NAME: ARORA, KRISHAN


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Narrative FTD, the second most common form of dementia after Alzheimer's disease, is an incurable illness which leads to inevitable cognitive and behavioral decline. FTD-Tau is characterized by accumulation of toxic aggregates of Tau protein in the brain. Our poor understanding of the molecular mechanisms mediating Tau toxicity onto neurons, and synapses, stands as a critical barrier to identifying effective treatments for FTD. This project will seek to address this gap in knowledge by examining how SUMOylation, a post-translational modification that our labs found to be impaired in FTD, controls tau aggregation and pathological action of Tau on mitochondrial and synaptic functions in animal models as well as patient-derived neurons carrying Tau mutations.

PI_NAMEs: FIORITI, LUANA ;QUINZII, CATARINA M. (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Animal Model;Antioxidants;Behavioral;behavioral impairment;Biochemical;Biological Availability;Biophysics;Brain;Cells;Cognitive;Data;Defect;Dementia;Development;Disease;effective therapy;Electrophysiology (science);enzyme activity;Enzymes;experimental study;Frontotemporal Dementia;Functional disorder;Gene Modified;Hippocampus;Impaired cognition;Impairment;improved;In Vitro;in vitro activity;in vivo;Induced pluripotent stem cell derived neurons;Intervention;Knowledge;Laboratory Finding;Link;Measures;Mediating;Memory;Memory Loss;Messenger RNA;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Mus;Neurons;Normal Statistical Distribution;overexpression;Oxidative Stress;paralogous gene;Pathologic;Patients;polypeptide;Post-Translational Protein Processing;prevent;Production;protein aggregation;Proteins;Reporting;Respiratory Chain;Role;Sequence Homology;Series;SUMO1 gene;Sumoylation Pathway;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;tau aggregation;tau mutation;tau Proteins;Tauopathies;Techniques;Testing;therapeutic target;therapeutically effective;Time;Toxic effect;Ubiquitin;Wild Type Mouse

PROJECT_TITLE: Role of SUMOylation in Mitochondrial/Synaptic Axis Dysfunction Induced by Abnormal Tau in FTD

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Precision Medicine

ORG_CITY: MADISON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This proposal will introduce new statistical approaches for quantifying and reducing biases in genome-wide association studies using family health history as proxy phenotypes. The projects will leverage the rich family health history survey data with matched genomic information in the AllofUs research program to interrogate methodological flaws in current GWAS-by-proxy approaches. The findings may fundamentally change how family health history information will be used in future complex disease genetic studies.

PI_NAMEs: LU, QIONGSHI  (contact)

PROGRAM_OFFICER_NAME: FENG, LI REBEKAH

PROJECT_TERMS: Acceleration;Affect;aged;Alzheimer's Disease;Alzheimer's disease related dementia;Awareness;biobank;Biological;case control;Child;Cognition;cohort;Cohort Studies;Complex;Data;Data Set;Dementia;design;Development;Diagnosis;Disease;Disease Outcome;disease phenotype;Education;Electronic Health Record;Family;Family health status;Family member;Future;Genetic;genetic association;Genetic Diseases;Genetic Research;Genetic study;genetic variant;Genome Components;genome wide association study;genomic data;genomic locus;Genomics;Guidelines;Health;Historical Survey;Human;human disease;improved;Knowledge;late life;Late-Onset Disorder;Link;Medical History;Meta-Analysis;Methodology;Methods;Neurodegenerative Disorders;novel;Outcome;Parental Ages;Parents;Participant;Patient Self-Report;Phenotype;Population;programs;Proxy;Recording of previous events;Research;Research Design;Research Personnel;Respondent;Sample Size;Sampling;social;social factors;Statistical Methods;statistics;success;Testing;trait

PROJECT_TITLE: Characterizing pervasive biases in genome-wide association study using family health history as proxy phenotypes


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Polygenic scores offer the promise of empowering precision medicine by assessing individual-level risk of heritable diseases based on a personal genome. This proposal aims to develop and apply methods that increase accuracy of genetic risk models by analyzing whole-genome sequencing data from population biobank data sets. The methods to be developed will incorporate structural variants and blood-derived somatic mutations not currently considered by existing approaches and will allow analyses of genome-wide SNP and indel variants to scale to hundreds of thousands of sequenced individuals.

PI_NAMEs: LOH, PO-RU  (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: age related;Algorithms;Alleles;analytical method;Base Pairing;biobank;Blood;Blood Cells;Cardiovascular Diseases;cardiovascular risk factor;causal variant;Chromosome abnormality;Clonal Expansion;cohort;Collaborations;Complex;Computer software;Computing Methodologies;cost;Data;Data Set;Disease;disorder risk;DNA;DNA Sequence;empowerment;European ancestry;experience;Frequencies;Future;Gene Frequency;Genes;Genetic;Genetic Diseases;Genetic Models;Genetic Polymorphism;Genetic Risk;genetic risk factor;genetic variant;Genetic Variation;Genome;genome sequencing;genome-wide;genome-wide analysis;Genomics;Genotype;Haplotypes;Hematologic Neoplasms;Heritability;high risk;human disease;improved;Individual;Inherited;insertion/deletion mutation;Letters;Link;Mediating;Memory;Methodology;Methods;Modeling;Mutation;Mutation Detection;Performance;Point Mutation;polygenic risk score;Population;precision medicine;Publications;rare variant;Research;Resolution;Resources;Risk;risk prediction;risk variant;Sampling;Single Nucleotide Polymorphism;SNP array;Somatic Mutation;Source;Statistical Algorithm;Statistical Methods;Structure;Therapeutic;Training;training data;trait;Variant;whole genome

PROJECT_TITLE: Leveraging biobank-scale whole-genome sequencing for polygenic risk prediction

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This proposal promotes intergenerational cardiovascular health (CVH) of women and children in the high burden St. Louis, Missouri, metro region, by rigorously testing HEALTH (Healthy Eating Active Living Taught at Home). This intervention is delivered through the Parents as Teachers (PAT) evidence-based home visiting model in partnership with the study team at Washington University in St. Louis (WUStL), and will further benefit from the ENRICH Collaborative. We will apply expertise in implementation science to ensure the intervention has equitable application and impact across PAT and the ENRICH Collaborative.

PI_NAMEs: DAVILA-ROMAN, VICTOR G.;HAIRE-JOSHU, DEBRA  (contact);TABAK, RACHEL G

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: active lifestyle;Age;American Heart Association;Behavior;Behavioral;Biological;Birth;Black race;Blood Pressure;Body mass index;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Characteristics;Child;child bearing;Child Health;Childbirth;Cholesterol;Chronic Disease;clinical research site;Clinical Trials;Communities;Complex;Diet;Dose;Educational process of instructing;Effectiveness;Enrollment;Ensure;Equity;evidence base;Evidence based practice;experience;Family;follow-up;food insecurity;Foundations;Funding;Generations;Gestational Diabetes;Glycosylated hemoglobin A;health assessment;health disparity;health equity;Healthy Eating;healthy weight;Home;Home visitation;Housing;housing instability;Hybrids;Implementation readiness;implementation science;improved;Individual;innovation;intergenerational;Intervention;kindergarten;Latinx;Lead;Learning;Life;Life Style;lifestyle intervention;Low income;Measures;Missouri;Modeling;Morbidity - disease rate;mortality;Mothers;Outcome;Parent-Child Relations;parental influence;parenting intervention;Parents;Patient Recruitments;Persons;Phase;Physical activity;pragmatic randomized trial;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnant Women;prenatal;Preschool Child;prevent;programs;Protocols documentation;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Resources;Scientific Advances and Accomplishments;screening;Site;Sleep;Smoking;social health determinants;socioeconomic disadvantage;Specific qualifier value;study population;teacher;Testing;Time;treatment as usual;United States National Institutes of Health;Universities;Visit;Washington;Weight;Women's Health;Work;young mother

PROJECT_TITLE: Enhancing Cardiovascular Health Equity in Mothers and Children Through Home Visiting


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Nutrition;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Endoplasmic reticulum (ER)-associated degradation (ERAD) is a principal ER quality-control mechanism; however, its (patho-)physiological role in vivo remains largely unclear. Excitingly, in a recent proteomics screen, we identified ceruloplasmin, a ferroxidase secreted by hepatocytes and a key player in iron metabolism, to be highly accumulated in the ER of ERAD-deficient liver. Hence, we will test the hypothesis that hepatic ERAD plays an essential role in systemic iron metabolism, at least in part, by controlling the turnover of ceruloplasmin protein in the liver.

PI_NAMEs: SUN, SHENGYI  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Aceruloplasminemia;Affect;Alleles;Anemia;Attenuated;autosome;Biochemical;Biogenesis;Biological Assay;cell type;Ceruloplasmin;Circulation;Clinical;cofactor;Data;Defect;diabetes risk;Disease;Dominant-Negative Mutation;Endoplasmic Reticulum;Event;Exhibits;Growth;Health;Hepatic;Hepatocyte;Homeostasis;Human;in vivo;Individual;insight;interest;Iron;iron deficiency;iron metabolism;Iron Metabolism Disorders;Iron Overload;iron oxidation;Kidney Diseases;Laboratories;Link;Liver;Liver diseases;loss of function;Mediating;microcytic/hypochromic anemia;Missense Mutation;Modeling;Molecular;Molecular Weight;Mus;mutant;Mutation;novel;Organ;Pathogenesis;Pathogenicity;Pathologic;Peripheral;Physiological;Physiology;Play;prevent;protein complex;protein folding;protein misfolding;Proteins;Proteomics;proteostasis;proteotoxicity;Quality Control;recruit;Regulation;Reporting;Resistance;response;restraint;Role;Stress;Testing;Tissues;Toxic effect;ubiquitin-protein ligase;Yeasts

PROJECT_TITLE: Novel role of endoplasmic reticulum-associated degradation in iron metabolism

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PI_NAMEs: DEUTSCH, ERIC ;KOSLICKI, DAVID ;RAMSEY, STEPHEN A. (contact)

PROGRAM_OFFICER_NAME: BECK, TYLER

PROJECT_TERMS: Autonomous Relay Agent;data translator;Development

PROJECT_TITLE: Biomedical Data Translator Development of Autonomous Relay Agent: ARAX


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PI_NAMEs: SU, ANDREW I (contact)

PROJECT_TITLE: BioThings Explorer: A platform for distributed knowledge integration across biomedical APIs


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PI_NAMEs: BAUMGARTNER, WILLIAM ANTHONY (contact)

PROJECT_TITLE: High Performance Text Mining for Translator


NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PI_NAMEs: FLANNICK, JASON  (contact)

PROJECT_TERMS: Address;Aloral;Architecture;Bioinformatics;Biological;Catalogs;causal variant;Cell Physiology;Chromatin;ClinVar;Collaborations;Collection;Complex;complex data;Computational algorithm;Computational Biology;computational pipelines;computer science;Data;data analysis pipeline;data harmonization;data integration;Data Set;Data Sources;data translator;Disease;disease classification;Disease susceptibility;disorder risk;epigenomic profiling;Feasibility Studies;Foundations;functional genomics;Genes;Genetic;genetic association;Genetic Diseases;genetic variant;genomic data;Genomic Segment;Goals;Gold;graph database;Human;human disease;Human Genetics;improved;insight;Interview;Knowledge;Knowledge Portal;Link;Mediating;Methodology;Methods;Modeling;Molecular;Online Mendelian Inheritance In Man;open source;Pathogenesis;Pathway interactions;Positioning Attribute;programs;Protocols documentation;Provider;Rare Diseases;Resources;Risk;Running;Science;Service provision;Source;Specific qualifier value;Susceptibility Gene;System;Techniques;Testing;Tissues;tool;Translating;Translations;United States National Institutes of Health;Untranslated RNA;Vision;web portal

PROJECT_TITLE: A Complex Disease Genetics Knowledge Provider for Biomedical Data Translator


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Nutrition;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE This type 1 hybrid effectiveness/implementation trial will estimate the effectiveness and potential sustainability of NFP-Heart. If successful, it can be rapidly disseminated to the >260 organizations delivering NFP nationwide to promote CVH in diverse, under-resourced mothers and offspring.

PI_NAMEs: ALLISON, MANDY ATLEE (contact);SAUDER, KATHERINE A.

PROJECT_TERMS: acceptability and feasibility;active lifestyle;Address;Adult;Birth;Blood Pressure;Body Composition;Body mass index;Body Weight decreased;Breast Feeding;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cause of Death;Characteristics;Child;Child Abuse and Neglect;Child Rearing;Cholesterol;Clinic;Cognitive;Collaborations;Colorado;Consolidated Framework for Implementation Research;critical period;Data;design;Development;diabetes prevention program;Diet;Discipline of Nursing;Disease;Dose;Early Intervention;early pregnancy;Economics;Education;Effectiveness;effectiveness/implementation trial;Employment;ethnic minority;evidence base;Family Nursing;Family Planning;Fathers;Fetal Development;Glucose;Health;Health Insurance;health of the mother;Health Promotion;Healthcare Systems;Healthy Eating;Heart;Home;Home visitation;implementation intervention;improved;Income;Individual;infancy;Infant Care;Injury;intergenerational;Intervention;intervention delivery;Life;lifestyle intervention;Low Income Population;Marriage;Maternal and Child Health;Measures;Mental Health;Methods;Modeling;Mothers;Nulliparity;Nurses;offspring;Outcome;Participant;Persons;Pilot Projects;Population;post pregnancy;Postpartum Period;Pregnancy;pregnancy hypertension;Pregnant Women;prenatal;primary outcome;Procedures;Process;Program Acceptability;programs;Protocols documentation;racial minority;recruit;Reporting;reproductive;Request for Applications;Resources;response;Safety;safety net;Smoking;smoking cessation;smoking exposure;social health determinants;Social Network;Time;treatment as usual;Unemployment;United States;Urban Health;Visiting Nurse;Weight;Weight Gain;Woman;young woman

PROJECT_TITLE: Colorado Nurse Family Heart Trial for the ENRICH program


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE (Parent Grant) The proposed research is relevant to public health since it focuses on understanding the immune evasion mechanism deployed by the human pathogen Schistosoma mansoni. Completion of the proposed study will bring new insights to how schistosomes operate inside the human host and identify potential targets for future therapeutic design that could aid in combating schistosomiasis.

PI_NAMEs: LEE, JAYHUN  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Affect;Anterior;Binding;Biological Assay;Biology;Blood;Blood Circulation;Candidate Disease Gene;cell type;Cells;Complement;Coupled;Cytolysis;Data;design;Development;Ensure;Environment;esophageal gland;feeding;fighting;Future;Gastrointestinal tract structure;Genes;Human;human pathogen;Immune;Immune Evasion;Immune system;In Vitro;Individual;Ingestion;innovation;insight;interest;Mediating;Organ;Parasites;parent grant;Platyhelminths;Play;Praziquantel;prevent;Proteins;Public Health;Publishing;Research;RNA Interference;Role;Schistosoma;Schistosoma mansoni;Schistosomiasis;Skin;Therapeutic;therapeutic target;Tissues;transcriptome sequencing;Work

PROJECT_TITLE: Esophageal gland-mediated immune evasion by the human parasite Schistosoma mansoni

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Obesity is a major public health concern, as it increases the risk for diabetes, heart disease and certain forms of cancer. Obesity, particularly in its most severe form, has an extremely strong genetic basis. Unfortunately, most of the genes that predispose people to obesity, as well as the molecular and cellular pathways those genes participate in, remain unknown. This project builds on the expertise and established collaborative work of two investigators to illuminate how dysfunction of neuronal primary cilium, a specific sub-cellular compartment that functions as an intercellular antenna, causes obesity.

PI_NAMEs: REITER, JEREMY F;VAISSE, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Address;Adenylate Cyclase;Affect;Brain;Calories;Cell Surface Extensions;Cells;Cilia;ciliopathy;Communication;Coupled;CRISPR interference;CRISPR/Cas technology;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cytoplasm;Data;Defect;Desire for food;diabetes risk;Disease;experimental study;Funding;G-Protein-Coupled Receptors;Gene Expression;Genes;Genetic;genetic approach;genetic variant;GTP-Binding Protein alpha Subunits, Gs;Heart Diseases;Homeostasis;Human;Hyperphagia;Hypothalamic structure;in vivo;Inherited;insight;intercellular communication;Laboratories;Leptin;Ligands;Malignant Neoplasms;Melanocortin 4 Receptor;Melanocortin 4 receptor mutation;Molecular;mouse model;Mus;Mutation;Neuronal Dysfunction;Neurons;novel;Obesity;optogenetics;paraventricular nucleus;Pathway interactions;Persons;Positioning Attribute;Proteins;Public Health;receptor;receptor function;Receptor Signaling;Regulation;Research Personnel;Role;Second Messenger Systems;Signal Transduction;Surface;Susceptibility Gene;Synapses;targeted delivery;Testing;tool;trafficking;Work;α-Melanocyte stimulating hormone

PROJECT_TITLE: Obesity in ciliopathies: How neuronal primary cilia control appetite

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Sex steroids regulate body weight and energy homeostasis, but central mechanisms underlying these effects are not fully elucidated. This research proposal aims to establish the medial amygdala as an integrating center for neurosteroid testosterone/estrogen signaling in energy homeostasis. Results from this work will provide some important clues regarding one of the fundamental mechanisms contributing to body weight control.

PI_NAMEs: XU, PINGWEN  (contact)

PROJECT_TERMS: adenovirus mediated delivery;Adrenal Glands;Adrenalectomy;age related;Agonist;Amygdaloid structure;androgen deprivation therapy;Androgen Receptor;androgenic;Androgens;Aromatase;Binding;Body mass index;Body Temperature;Body Weight;Body Weight decreased;Brain;Brain region;Castration;Central Nervous System;Coupled;Data;Development;Diet;diet-induced obesity;Dose;Electrophysiology (science);energy balance;Energy Metabolism;Enzymes;Epidemic;ESR1 gene;Estradiol;Estrogen Receptor 2;estrogenic;Estrogens;Female;Gonadal Steroid Hormones;High Fat Diet;Homeostasis;Hormones;Human;Hypogonadism;Individual;Injections;Knockout Mice;Ligands;LoxP-flanked allele;male;male sex hormones;Medial;Mediating;men;Metabolic;Metabolic Pathway;Metabolic syndrome;Mouse Strains;Mus;Mutant Strains Mice;Mutation;neural;neural circuit;Neurons;neurosteroids;novel;Obesity;Obesity associated disease;obesity development;obesity prevention;Ovariectomy;overexpression;Phenotype;Physical activity;Physical Stimulation;Physiological;Play;prevent;receptor;Receptor Signaling;Regulation;Reporting;Research;Research Proposals;Role;sex;side effect;Signal Pathway;Signal Transduction;Stanolone;Steroids;System;Testing;Testosterone;Weight Gain;weight maintenance;Weight maintenance regimen;Work

PROJECT_TITLE: Testosterone and estrogen signaling pathways in the medial amygdala interact to control energy homeostasis

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

PI_NAMEs: BARANZINI, SERGIO E;HUANG, SUI  (contact)

PROJECT_TERMS: Address;algorithmic bias;Algorithms;antagonist;Autonomous Relay Agent;Big Data;biobank;cancer risk;Chickens;cohort;Conflict (Psychology);Data;Data Analytics;Data Set;Databases;Development;Disease;disorder risk;egg;Epidemiology;Epistemology;experience;improved;interoperability;Knowledge;knowledge graph;knowledge network;Learning;Malignant Neoplasms;Measurement;Medical;medical specialties;Molecular;Multiomic Data;multiple omics;Names;National Center for Advancing Translational Sciences;Pathway interactions;Process;programs;Proteins;Provider;Quality Control;Recording of previous events;Research;Research Personnel;Resources;Role;Science;Signal Transduction;Source;stem cells;System;Technical Expertise;Testing;tool;Vision;Vitamin K;Walking;Weight;Work

PROJECT_TITLE: EVIDARA: Automated Evidential Support from Raw Data for relay agents in Biomedical KG Queries


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Digestive Diseases;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: ITHACA

ORG_NAME: ZYMTRONIX CATALYTIC SYSTEMS, INC.

PHR: Narrative - Human milk oligosaccharides (HMOs), abundant components of human milk, hold extraordinary potential as biomedical and therapeutic agents to treat inflammatory, autoimmune, and allergic diseases, but the unavailability of methods to produce them in large quantities and affordable cost has hindered their systematic study and efforts to leverage their biomedical potential. To significantly improve HMO production efficiency, Zymtronix is applying its proprietary multienzyme immobilization and cell-free biocatalytic manufacturing systems to produce most HMO milk constituents and demonstrated successful production of multiple complex HMOs in Phase I. In this Phase II project, the company will focus on a single syalilated HMO that is more complex than any other previously synthesized using these methods which has been demonstrated to be highly protective against necrotizing enterocolitis (NEC) – a devastating inflammatory gastrointestinal disorder with a 10-50% mortality rate in premature infants and total annual cost burdens upwards of $1B.

PI_NAMEs: CORGIE, STEPHANE CEDRIC (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Adult;Allergic Disease;Animal Model;Anti-Inflammatory Agents;Autoimmune Diseases;Bacteria;Bacterial Adhesins;Biomanufacturing;Breastfed infant;Capital Expenditures;Cells;cGMP production;chemical synthesis;Child Nutrition;Clinic;college;Communities;Complex;cost;cost effective;cytokine;Death Rate;Dependence;Development;Disease;Dose;efficacy study;enzyme activity;Enzymes;Epithelium;feeding;Feeds;Fermentation;Fucose;Funding;Future;Gastroenterology;Gastrointestinal Diseases;Goals;Grant;gut microbiome;Hand;Human;Human Milk;human milk oligosaccharides;Immobilized Enzymes;Immune;immunoregulation;improved;improved outcome;Incidence;Industrialization;Infant;Infant formula;infection risk;Inflammatory;Investigation;Laboratories;Lactose;Legal patent;Leucocytic infiltrate;leukocyte activation;manufacturing systems;Measurement;Medicine;Metabolic;meter;Methodology;Methods;Milk;Mission;Mucous Membrane;Necrotizing Enterocolitis;neonate;novel;nutrition;Outcome;Parasites;pathogen;Phase;Polysaccharides;prebiotics;Premature Infant;prevent;Prevention;primary outcome;Probiotics;Procedures;Process;Production;Property;prophylactic;Rattus;Reaction;Research;Research Personnel;response;Risk;scale up;Severities;Shapes;Sialic Acids;sialylation;Small Business Innovation Research Grant;Source;Surface;System;Technology;technology platform;Therapeutic;Therapeutic Agents;Time;treatment group;United States National Institutes of Health;Viral;Work

PROJECT_TITLE: Scaling-up flow processes for the chemoenzymatic synthesis of a sialylated glycan

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-G (10)]


PHR: PROJECT NARRATIVE The bacterial cell envelope is composed of sugary layers that impede antimicrobials and the immune system. The building blocks that produce these layers are assembled on a lipid carrier that transports them from the inside of the cell to the outside. This proposal describes a program to exploit this lipid carrier to enhance vaccine production strategies while at the same time defining new mechanisms required for cell envelope assembly.

PI_NAMEs: JORGENSON, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Affect;Anti-Bacterial Agents;antimicrobial;Bacteria;cell envelope;Cell membrane;Cell Shape;Cell Wall;Cells;Clinical;Cytoplasm;design;Environmental Hazards;Escherichia coli;Genetic Screening;Gram-Negative Bacteria;Immune system;inhibitor;inorganic phosphate;Knowledge;Life;Lipids;Membrane;Metabolism;mutant;Osmotic Pressure;Pathway interactions;Peptidoglycan;Polymers;Polysaccharides;Process;programs;Recycling;Signal Transduction;Surface;Thinness;Time;tool;Vaccine Production;Vaccines;Work

PROJECT_TITLE: Manipulating undecaprenyl phosphate levels to decipher mechanisms of competing cell envelope assembly pathways in Escherichia coli

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Microbiome;Neurosciences;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Narrative Maternal obesity and consumption of high calorie diets continue to be public health concerns as the perinatal environment provides support that is critical to the proper development and health of offspring. Preliminary data suggests that maternal high fat (HF) diet during development is associated with changes in meal patterning suggesting impaired post-ingestive feedback along the gut-brain axis that may be a result of with microbiota dysbiosis. The current proposal will investigate how perinatal HF diet and dysbiosis alters gut-brain axis development and vagally- mediated controls of feeding in HF offspring and leads to increased susceptibility to obesity and other metabolic disorders.

PI_NAMEs: TAMASHIRO, KELLIE L. K. (contact)

PROJECT_TERMS: Adult;Affect;Afferent Neurons;Behavior;Birth;Brain;Calcium;Calories;Cell Count;Cell Physiology;Child;Cholecystokinin;combinatorial;Communication;comorbidity;Consumption;Coronary Arteriosclerosis;critical period;Data;Development;Diet;diet-induced obesity;dysbiosis;early life exposure;Eating;Energy consumption;Enteroendocrine Cell;Environment;Epidemic;experimental study;Exposure to;Fat-Restricted Diet;Fatty acid glycerol esters;Feedback;feeding;Fetus;Future;genome wide association study;genomic locus;Germ-Free;gut dysbiosis;gut microbiota;gut-brain axis;Health;High Fat Diet;Homeostasis;Hormones;Hyperphagia;Hypertension;Image;Impairment;improved;Individual;Inflammation;Inflammatory;innovation;Interdisciplinary Study;Intervention;intestinal crypt;Intestinal permeability;Intestines;Lactation;Leaky Gut;Life;Malignant Neoplasms;maternal obesity;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic syndrome;Methods;microbiota;microbiota composition;Modeling;mother nutrition;Mothers;neonate;neural;Neurobiology;Neurons;neurotransmission;Non-Insulin-Dependent Diabetes Mellitus;normal microbiota;Nutrient;nutrition;Obesity;obesity in children;offspring;Outcome;Overweight;Pattern;Perinatal;perinatal environment;Perinatal Exposure;Peripheral;Phenotype;physical inactivity;postnatal;postnatal period;prebiotics;Predisposition;Pregnancy;Prevalence;prevent;Public Health;Rattus;Regulation;Resistance;response;Risk;Role;Satiation;Sensory;Signal Transduction;skills;Starch;Stimulus;Structure;systemic inflammatory response;Testing;therapy development;Time;Tracer;translation to humans;Vagus nerve structure;Virus;Weaning;Weight Gain

PROJECT_TITLE: Maternal diet and programming of offspring gut-brain axis


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Diabetes;Pediatric;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE β-cells derived from human stem cells represent a transformative, unlimited source of insulin-producing cells for the treatment of type 1 diabetes, but translation of these cells is hindered by the lack long-term engraftment and function without chronic immunosuppression and use of encapsulation devices that limit engraftment. The objective of this project is to engineer advanced biomaterial delivery technologies to (i) enhance vascularization, survival, and engraftment of SC-β cells and (ii) protect them from rejection by the immune system without the need for encapsulation or chronic immunosuppression.

PI_NAMEs: GARCIA, ANDRES J (contact);MARKMANN, JAMES FRANCIS;SHIRWAN, HAVAL

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Acceleration;Adult;Affect;Animal Model;Autoimmune Diseases;Beta Cell;Biocompatible Materials;Blood Glucose;Body Weight;C-Peptide;Cadaver;Cell Physiology;cell replacement therapy;Cell Survival;Cell Transplantation;Cells;Child;Chronic;Clinical;clinical translation;Clinical Trials;Collagen;Complications of Diabetes Mellitus;delivery vehicle;Development;Devices;diabetes risk;diabetic;Disease;Encapsulated;Engineering;Engraftment;euglycemia;Fasting;Formulation;Future;Gel;Glucose tolerance test;glycemic control;graft function;Graft Survival;Health Care Costs;Homologous Transplantation;Human;human pluripotent stem cell;human stem cells;humanized mouse;Hydrogels;Hypoglycemia;hypoglycemia unawareness;Immune;Immune Evasion;Immune system;Immunocompetent;Immunocompromised Host;Immunologics;Immunology;immunoregulation;Immunosuppression;improved;Injectable;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans Transplantation;Lead;Modeling;Monitor;mouse model;Mus;nephrotoxicity;nonhuman primate;Patients;Pilot Projects;prevent;Prevention;response;Risk;SCID Beige Mouse;Signal Transduction;Site;Source;stem cell biology;Structure of beta Cell of islet;subcutaneous;Technology;Translations;Transplantation;Vascular Endothelial Growth Factors;Vascularization;Vasculogenic;Work

PROJECT_TITLE: Hydrogels for human beta cell survival, function and evasion of immune rejection


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Liver Disease;Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative The rapidly increasing prevalence and serious complications of type 2 diabetes (T2D) underscore its importance as a public health issue. Despite advances in therapeutic options, optimizing glycemic control still remains an elusive goal. Since excessive glucose production is the main source of increased glucose levels in T2D, understanding mechanisms that regulate glucose production would have important therapeutic implications. Our recent data suggest that the brain exerts important restraining effects on the liver’s glucose production, but that elevated fatty acid levels in T2D impair this regulation. Using studies in both humans and rats, we hope to clearly elucidate the impact of fatty acids on the cells in the brain that control glucose production. These studies could therefore lead to new therapeutic target(s) for the treatment of T2D.

PI_NAMEs: HAWKINS, MEREDITH A (contact);ROUTH, VANESSA H

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Address;antioxidant enzyme;ATP sensitive potassium channel complex;Beta Cell;Blood Glucose;blood glucose regulation;Brain;brain control;Cells;Central Nervous System;Chronic;Closure by clamp;Complications of Diabetes Mellitus;Data;Defect;Diabetes Mellitus;diabetic;diabetic rat;Diazoxide;endoplasmic reticulum stress;euglycemia;extracellular;Fasting;Fatty Acids;Glucose;glucose production;glycemic control;Goals;Hepatic;Human;Hyperglycemia;Hypothalamic structure;Impairment;Individual;Infusion procedures;Insulin;Lead;Lipids;Liver;liver transplantation;Mediating;Mitochondria;nerve supply;Neurons;new therapeutic target;Nicotinic Acids;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel therapeutics;Nutritional status;Obesity;Organ;overexpression;Pancreas;patch clamp;Patients;Play;Population;Potassium;Prevalence;prevent;Process;Public Health;Rattus;Regulation;Regulatory Pathway;restoration;restraint;Rodent;Role;Signal Pathway;Signal Transduction;Somatostatin;Source;Testing;Therapeutic;Transplant Recipients;TXN gene;Work

PROJECT_TITLE: Restoring Central Regulation of Glucose Production in Type 2 Diabetes

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Estrogen;Heart Disease;Heart Disease - Coronary Heart Disease;Liver Disease;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Obesity has dramatically increased the burden of cardiovascular disease, and a major goal of the NIH/NIDDK is to reduce this burden. The goal of this application is to discover how to target liver estrogen pathways to improve glucose and lipid abnormalities in obesity and diabetes, which is expected to help reverse the impact of obesity on cardiovascular risk. Our project identifies pathways that mediate sex differences in cardiovascular disease, which is also an NIH priority area.

PI_NAMEs: STAFFORD, JOHN MICHAEL (contact)

PROJECT_TERMS: Anti-Inflammatory Agents;Area;atheroprotective;Atherosclerosis;Attenuated;Binding Proteins;Biology;Carbohydrates;Cardiovascular Diseases;cardiovascular risk factor;Cholesterol;Chronic;Clinical Trials;Closure by clamp;Coronary heart disease;Dependence;Diabetes Mellitus;diabetic;diet-induced obesity;Diphtheria Toxin;Disease;ESR1 gene;Estradiol;estrogenic;Estrogens;Fatty acid glycerol esters;fatty acid oxidation;Fatty Liver;Female;Funding;Glucagon;Glucose;glucose metabolism;glycemic control;Glycogen;Goals;heart disease risk;Hepatic;Hepatocyte;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Human;Hyperglycemia;Hyperinsulinism;Impairment;improved;innovation;insulin sensitivity;Isotopes;Knock-out;Knowledge;Link;lipid biosynthesis;lipid metabolism;Lipids;Liver;Long-Term Effects;male;Mediating;men;Menopause;Metabolic;Metabolic Diseases;Metabolism;Modeling;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nutrient;Obesity;Obesity associated disease;Output;Pathway interactions;Peptides;Physiology;Play;pre-clinical;Prevalence;Property;protective effect;protein activation;Response Elements;reverse cholesterol transport;Risk;Risk Factors;sex;Sex Differences;Side;Signal Transduction;Stress;Techniques;Testing;Therapeutic;therapeutic target;Tissues;Tracer;Triglycerides;United States National Institutes of Health;Very low density lipoprotein;Woman;women's outcomes

PROJECT_TITLE: Therapeutic Potential of Estrogen-Regulated Metabolism and Cardiovascular Risk


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: JACKSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative Insulin resistance is a risk factor for metabolic syndrome and is often observed in patients suffering from obesity, a major risk factor for cardiovascular disease. Endothelin-1 is increased in patients with obesity and may contribute to insulin resistance. The current proposal will elucidate mechanism by which ET-1 contributes to insulin resistance and will provide preclinical evidence to determine if ET-1 antagonists improve insulin sensitivity and cardiovascular outcomes associated with insulin resistance.

PI_NAMEs: SPEED, JOSHUA S (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Address;Adipocytes;adiponectin;Adipose tissue;Affect;Agonist;American;antagonist;Attenuated;Blood Glucose;blood glucose regulation;bosentan;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Clinical;Data;Diabetes Mellitus;diet-induced obesity;Endothelial Cells;Endothelin A Receptor;Endothelin-1;Fasting;Fatty acid glycerol esters;feeding;gain of function;Glucose;Glucose Intolerance;glucose metabolism;glucose tolerance;glucose uptake;Health;High Fat Diet;Human;Hypothalamic structure;Hypoxia;hypoxia inducible factor 1;impaired glucose tolerance;Impairment;improved;In Vitro;in vivo;Incidence;Individual;inhibitor;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;Knock-out;Knockout Mice;Laboratories;leptin receptor;lipid metabolism;Lipids;Lipolysis;Liver;LoxP-flanked allele;Mediating;Messenger RNA;Metabolic Diseases;Metabolic syndrome;Modeling;Morbid Obesity;mouse model;Mus;Muscle;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;obese patients;Obesity;Outcome;overexpression;Patients;Peptides;Peripheral;pharmacologic;Physiological;Plasma;Population;PPAR gamma;pre-clinical;Prevalence;Production;receptor;Receptor Activation;Receptor Inhibition;response;Risk Factors;Rodent;Rodent Model;Scheme;Signal Pathway;Sleep Apnea Syndromes;System;Techniques;Testing;Thinness;Tissues;Transgenic Mice;Triglycerides;Visceral;western diet

PROJECT_TITLE: Endothelin-1 in Obesity and Insulin Resistance


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Eye Disease and Disorders of Vision;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Mustard gas keratopathy (MGK) is a sight-threatening, potentially blinding, chronic corneal disease after mustard exposure. Clinically characterized as persistent corneal epithelial erosions, ocular dryness and pain, and limbal stem cell deficiency, MGK still lacks definitive treatment with the underlying pathogenic mechanisms leading to the chronicity of ocular manifestations after exposure largely unknown. Existing evidence shows chronic inflammation as an important component of MGK, and thus this project, grounded on an established pre-clinical model in our lab, proposes to investigate the precise immune mechanisms that drive the development of MGK after acute mustard exposure.

PI_NAMEs: CHEN, YIHE  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acute;Adverse effects;Antibody Therapy;Antigen-Presenting Cells;Automobile Driving;biological adaptation to stress;CD80 gene;CD86 gene;cell injury;cell motility;Cell Separation;Cells;chemokine;Chronic;Chronic Disease;Chronic lung disease;Clinical;clinical phenotype;Cornea;Corneal Diseases;corneal epithelium;cytokine;Data;Development;Diffuse;draining lymph node;Dry Eye Syndromes;Dryness;Edema;Environment;Epithelial Cells;Epithelium;Exhibits;Exposure to;Eye;Eye diseases;Frequencies;General Population;healing;IL17 gene;Immune;Immunity;Impairment;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Interleukin-1 beta;interleukin-23;Interleukin-6;Keratopathy;Knowledge;Lesion;Light;limbal;long-term sequelae;Lymphoid Tissue;Macrophage;MAP Kinase Gene;mass casualty;Mechlorethamine;Mediating;Medical;migration;Modeling;Molecular Target;mouse model;Mus;Mustard;Mustard Agent;Mustard Gas;nerve damage;neutralizing antibody;novel;ocular pain;ocular surface;Operative Surgical Procedures;Organ;Pain;Palliative Care;Pathogenesis;Pathogenicity;Pathologic;Patients;Penetration;Phase;Phenotype;Play;Pre-Clinical Model;prevent;Production;recruit;Recurrence;Reporting;response;Role;service member;stem cells;Stress;T cell response;Testing;Therapeutic;Time;Tissues;TNF gene;TNFRSF5 gene;Transforming Growth Factor beta;Vision;Visual System;Work

PROJECT_TITLE: Immune Mechanisms of Chronic Ocular Damage after Acute Exposure to Nitrogen Mustard

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-D (CA)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: CARSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CALIFORNIA STATE UNIV-DOMINGUEZ HILLS

PHR: PROJECT NARRATIVE This project aims to evaluate the role of two key affective skills – emotional granularity and interoceptive accuracy – that support coping with stress and uncertainty in adolescence, their relation to childhood adversity, and their role in contributing to resilience or vulnerability to the mental health impacts of daily stressors. A better understanding of the sources of individual differences in emotional granularity and interoceptive accuracy will allow for improvement of existing effective interventions targeting these skills and application of those interventions to improve outcomes among youth exposed to childhood adversity.

PI_NAMEs: WEISSMAN, DAVID G (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Adolescence;Adolescent;adverse childhood events;Adverse event;Affective;aged;Awareness;Behavioral;Brain;career;Categories;Child;childhood adversity;Chronic;Clinical;Cognitive;computerized data processing;coping;Data Analyses;Data Collection;deprivation;Development;Dimensions;Ecological momentary assessment;effective intervention;emotion regulation;Emotional;Emotions;Ensure;Exercise;Expectancy;experience;Exposure to;Feedback;Female;follow up assessment;follow-up;Functional disorder;Future;Goals;Heart Rate;hypothalamic-pituitary-adrenal axis;improved;improved outcome;Individual Differences;Interoception;Intervention;Interview;Label;Laboratories;Learning;Link;Measures;Mediating;Mediator;Mental Health;Methods;Minority;minority student;Modeling;multimodality;neglect;neural;Parents;Participant;Pathway interactions;Personal Satisfaction;Physiological;Poverty;pre-clinical;Process;Psychopathology;Psychophysiology;Psychosocial Stress;Questionnaires;recruit;Regulation;Reporting;Research;Research Methodology;research study;resilience;Resources;Rest;Risk;Role;Sampling;Science;Services;skills;social;Source;Stress;Stress and Coping;stress management;stress resilience;Stressful Event;stressor;Structure;Students;Symptoms;Time;Uncertainty;Underrepresented Students;United States National Institutes of Health;violence exposure;Visit;Youth

PROJECT_TITLE: Emotional Granularity and Interoceptive Accuracy: Affective Skills Linking Dimensions of Childhood Adversity with Adolescent Stress Vulnerability

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (SB)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Digestive Diseases;Food Allergies;Infectious Diseases;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: NARRATIVE Understanding how the immune system impacts the onset and progression of Alzheimer’s disease is critical to identifying new treatments for this devastating disease. Emerging allergic diseases that can drive systemic inflammation may be critical to understanding the pathogenesis of Alzheimer’s disease. This project aims to establish a relationship between tick-induced allergy to mammalian meat and neuroinflammatory molecular and T-cell signatures, thereby establishing a new paradigm for the immunopathogenesis of Alzheimer’s disease.

PI_NAMEs: PLATTS-MILLS, THOMAS A. (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Acute;Address;Adult;Affect;Age;Aging;Algorithms;Allergens;Allergic;Allergic Disease;alpha-gal syndrome;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer’s disease biomarker;American;analytical method;Anaphylaxis;Antibodies;Antigens;Atherosclerosis;Biological Assay;Biological Specimen Banks;Blood;Body System;Brain;candidate marker;Carbohydrates;Cardiovascular Diseases;Cause of Death;Cells;Central Nervous System;chemokine;Chronic;Cluster Analysis;Cognitive deficits;cohort;comparison group;Complex;COVID-19 patient;cytokine;Data;Dementia;design;Development;Disease;Eating;Encephalitis;Epidemiology;Event;experience;Flow Cytometry;follow-up;food allergen;galactosyl-(1-3)galactose;gastrointestinal symptom;Gastrointestinal tract structure;Grant;high dimensionality;High Prevalence;Human;human model;human old age (65+);Hypersensitivity;IgE;Immune;Immune response;Immune system;Immunology;Individual;Infiltration;Inflammation;Inflammatory;insight;Link;Machine Learning;machine learning method;Measures;Meat;Mediating;Methods;Molecular;Molecular Target;Monitor;Neurocognitive;Neurocognitive Deficit;neurocognitive disorder;neuroinflammation;novel;novel therapeutics;older adult;Oligosaccharides;Outcome;parent grant;Parents;Pathogenesis;Patients;Peripheral;Population;Prevalence;Process;profiles in patients;Proteins;Public Health;Reporting;Research;Resources;Role;Sampling;Scientist;Serum;severe COVID-19;Specimen;Symptoms;Syndrome;systemic inflammatory response;T-Lymphocyte;Testing;tick bite;Ticks;tool;United States;Urticaria;Visit;Work;work-study

PROJECT_TITLE: IgE antibodies to the mammalian oligosaccharide galactose-alpha-1, 3-galactose (alpha-gal): immunology, epidemiology and relevance to allergic and inflammatory disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Diabetes;Immunotherapy;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The objective of this project is to induce localized immune tolerance to transplanted human beta cells derived from renewable stem cell sources as a treatment for type 1 diabetes. This project presents a significant step forward in the development of alternative, renewable, and off-the-shelf sources of insulin producing cells for current cell replacement therapy efforts. This project addresses the key technical challenge of systemic administration of immunosuppressive drugs to protect beta cell grafts through introduction of a highly localized immunomodulation and as such, represents the highest level of translational innovation.

PI_NAMEs: PHELPS, EDWARD  (contact);RUSS, HOLGER A.

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Adamantane;Address;anergy;Animal Model;antigen-specific T cells;Antigens;Apoptosis;Architecture;Area;Attenuated;Autoantigens;autoimmune pathogenesis;Autoimmunity;Automobile Driving;behavior influence;Beta Cell;beta cell replacement;beta-Cyclodextrins;Biocompatible Materials;Biological;Biological Assay;Biological Response Modifiers;Biology;Biomedical Engineering;Cadaver;Categories;cell killing;Cell Physiology;cell replacement therapy;Cell surface;Cell Transplantation;Cells;cellular engineering;Chemistry;Clone Cells;Coculture Techniques;Collaborations;compare effectiveness;crosslink;cytotoxic CD8 T cells;design;Development;Diabetes Mellitus;Diabetic mouse;effector T cell;Elements;Encapsulated;engineered stem cells;Engineering;Engraftment;Eragrostis;Exhibits;experimental study;Gel;Generations;Genes;Genome engineering;Glucose;graft function;Graft Rejection;Graft Survival;Human;human model;human stem cell-derived;humanized mouse;Hydrogels;Immune;Immune mediated destruction;Immune system;Immune Tolerance;Immunity;immunoengineering;Immunomodulators;immunoregulation;Immunosuppression;Immunosuppressive Agents;Immunotherapy;Impairment;In Vitro;in vitro Model;in vivo Model;Induction of Apoptosis;Injectable;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;islet;Islet Cell;Islets of Langerhans Transplantation;Knowledge;Ligands;Mechanics;Microspheres;novel;particle;Pathway interactions;Patients;Performance;Polyethylene Glycols;Porosity;pre-clinical;prevent;programmed cell death ligand 1;Property;Reaction;receptor;Resistance;response;revascularization;side effect;Source;Specificity;stem cell biology;stem cells;Structure;Surface;synergism;System;T cell response;T-Lymphocyte;Technology;Testing;therapeutic target;Thinness;TNF gene;Transgenic Animals;Transplantation;Vascularization;Work

PROJECT_TITLE: Local immune modulation for beta cell replacement therapy in type 1 diabetes

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative The incidence of type 1 diabetes (T1D), an autoimmune disease which affects millions of people worldwide, has been rising for the past half century. While both genetic and environmental factors contribute to the risk of developing T1D, recent studies indicate that early-life microbial interactions with the developing immune system offer a critical window of opportunity to influence the immune system’s development to prevent disease. Our study uses an innovative approach that leverages a community of early life microbes to identify microbial products and immune system pathways that may lead to therapies to prevent the development of T1D.

PI_NAMEs: SILVERMAN, MICHAEL A (contact)

PROJECT_TERMS: Adult;Affect;Alleles;Anatomy;Antigen Presentation;Antigens;Autoantigens;Autoimmune Diabetes;Autoimmune Diseases;Autoimmunity;Bacteria;Birth;CD4 Positive T Lymphocytes;Cells;Child;Childhood;Communities;Complex;Data;Development;Diabetes Mellitus;diabetes pathogenesis;Disease;early life exposure;effective therapy;Environmental Risk Factor;Exposure to;Genetic;genetic linkage;Genetic Models;Germ-Free;Gnotobiotic;Goals;Growth;gut microbes;gut microbiome;Haplotypes;Histocompatibility Antigens Class II;HLA Antigens;host microbiota;Human;Immune;Immune response;Immune system;Immunization;immunoregulation;In Vitro;in vivo;Inbred NOD Mice;Incidence;innovation;insight;Insulin-Dependent Diabetes Mellitus;intestinal homeostasis;Intestines;Investigation;islet autoimmunity;Knowledge;Life;Major Histocompatibility Complex;Maps;mass spectrometric imaging;Mediating;member;Metabolic;metabolomics;Microbe;microbial;microbial community;microbial products;microbiome;microbiota;microorganism antigen;microorganism interaction;Modeling;mouse model;Mucous Membrane;Mus;Pathway interactions;Peptides;Peripheral;Persons;Phylogenetic Analysis;Predisposition;prevent;Property;protective effect;Proteins;Publishing;rational design;Regulatory T-Lymphocyte;Research;response;restraint;Risk;Role;Shapes;Site;System;Systems Development;T cell receptor repertoire sequencing;T cell response;T-Lymphocyte;Testing;Therapeutic;Time;tool;Transgenic Mice;Transgenic Organisms;transmission process;validation studies;Weaning;Work

PROJECT_TITLE: Leveraging early-life microbes to prevent type 1 diabetes

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE Non-invasive recordings of human brain activity cannot identify whether the parts of the brain that generate them are undergoing excitation (increased neuronal firing) or inhibition (decreased neuronal firing). We aim to develop a novel non-invasive measure of this moment-to-moment physiological excitability of the human cortex by using the TMS-evoked potential (TEP) – an amplitude deflection in EEG recordings of human cortex that can be elicited by TMS stimulation. We will systematically elicit excitation or inhibition of the same brain area using cognitive processes known to differentially increase or decrease that area’s neuronal firing. We will then test whether these changes are reflected in amplitude changes of the TEP.

PI_NAMEs: WESSEL, JAN R (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Affect;Area;Basal Ganglia;blood oxygen level dependent;Brain;Brain region;Cognitive;cognitive load;cognitive process;cognitive task;Electroencephalography;Evoked Potentials;excitatory neuron;experimental study;extracellular;Eye;Eye Movements;follow-up;frontal eye fields;frontal lobe;Functional Magnetic Resonance Imaging;gaze;Goals;Human;indexing;Individual;inhibitory neuron;Investigation;Magnetic Resonance Imaging;Measures;Memory;Metabolic;Methods;Motor Cortex;Motor Evoked Potentials;Motor Neurons;Movement;Muscle;neural;neural circuit;Neurons;neurotransmission;novel;Physiologic pulse;Physiological;Population;Preparation;Proactive Inhibition;Property;Research;Role;Saccades;Scalp structure;Short-Term Memory;Signal Transduction;Testing;Thalamic structure;Transcranial magnetic stimulation;Work

PROJECT_TITLE: The TMS-evoked potential as a measure of cortical excitation and inhibition during cognitive processes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-H (02)]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Mental Health;Pediatric;Prevention

ORG_NAME: JOSLIN DIABETES CENTER

PHR: PROJECT NARRATIVE Adolescents and young adults with T1D, as a subgroup of the population with T1D, have the poorest glycemic control of all, reaching a peak mean A1c >9% around age 19; they, too, often experience diabetes distress. Diabetes distress is common in persons with type 1 diabetes (T1D) and contributes to suboptimal self-care behaviors and outcomes, especially for the high risk group of adolescents and young adults with T1D. In the proposed 2-year randomized clinical trial, we will implement and assess the impact of a behavioral/psycho- educational intervention to reduce diabetes distress, increase acceptance of self-care behaviors (with or without diabetes technologies), and improve glycemic outcomes in adolescents and young adults, aged 14-25 years, with T1D in order to optimize their short-term and long-term health.

PI_NAMEs: HOOD, KOREY K;LAFFEL, LORI M (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: active method;Adolescent;Adolescent and Young Adult;Age;age group;aged;American;Anger;Area;Attitude;Behavior;Behavioral;Boston;care burden;care delivery;Caring;Childhood;Clinic;Clinical;clinically significant;Collaborations;college;Complex;Continuous Glucose Monitor;Control Groups;COVID-19 pandemic;Data;Dedications;depression prevention;depressive symptoms;Development;Devices;diabetes control;diabetes distress;diabetes education;diabetes management;Diabetes Mellitus;diabetes self-management;Distress;Ensure;evidence base;experience;Frustration;Funding;Glucose;glycemic control;Glycosylated hemoglobin A;group intervention;Health;high risk;high risk population;improved;improved outcome;Individual;Insulin-Dependent Diabetes Mellitus;International;Intervention;intervention participants;Left;life span;Link;Measures;Medical;medical appointment;Mental Health;Meta-Analysis;Monitor;Moods;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Occupational;Outcome;Parents;Participant;Patient Outcomes Assessments;Perception;Persons;poor health outcome;Population;post intervention;primary endpoint;primary outcome;programs;psychoeducational intervention;psychosocial;psychosocial outcome;Randomized;randomized, clinical trials;Recommendation;recruit;remote visit;Research;Research Personnel;Risk;routine screening;Sampling;San Francisco;Schedule;Schools;secondary endpoint;secondary outcome;Self Care;skill acquisition;Societies;Subgroup;Surveys;Symptoms;Technology;Testing;Time;treatment as usual;uptake;usual care arm;virtual;Visit;young adult

PROJECT_TITLE: Improving Glycemia & Reducing Diabetes Distress in Adolescents & Young Adults with T1D

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Women's Health Research

ORG_CITY: FORT COLLINS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Project Narrative The proposed research is highly relevant to public health because the identification of efficacious interventions that integrate mental health-exercise training to improve insulin resistance in adolescents with obesity and depression offers the prospect of mitigating type 2 diabetes (T2D) risk. Adolescent females from historically disadvantaged racial/ethnic and socioeconomic backgrounds disproportionately experience elevated depression symptoms, physical inactivity, poor cardiorespiratory fitness, obesity, insulin resistance, and youth-onset T2D. By rigorously studying the efficacy of cognitive-behavioral therapy (CBT), exercise training, and their combinations to increase physical activity/fitness and ameliorate insulin resistance in adolescent females at-risk for T2D with elevated depression symptoms, the proposed research is poised to contribute to the NIDDK's mission to combat T2D and improve people's health and quality of life.

PI_NAMEs: SHOMAKER, LAUREN BERGER (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Accounting;Address;Adherence;Adolescence;Adolescent;Adult;Aftercare;arm;attentional control;Behavior Therapy;Body mass index;cardiorespiratory fitness;center for epidemiological studies depression scale;child depression;Chronic Disease;Cognitive Therapy;combat;Communities;comorbidity;comparative efficacy;Control Groups;cost;cost effective;cost effective intervention;Data;Depressed mood;depressive symptoms;Diabetes prevention;diabetes risk;Disadvantaged;Disease;Disproportionately impacts women;effective therapy;Effectiveness;efficacious intervention;efficacy study;Ethnic Origin;Ethnic Population;Exercise;exercise training;experience;Fasting;Female;Female Adolescents;fitness;follow-up;Frequencies;Goals;Health;Health education;Healthcare;High Risk Woman;Hour;improved;Individual;Insulin;Insulin Resistance;insulin sensitivity;Intervention;Interview;Life Expectancy;Mediating;Mediator;Mental Depression;Mental Health;Metabolic;Methods;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;Pathway interactions;Persons;Phenotype;Physical activity;Physical Fitness;physical inactivity;Physiological;post intervention;Prevention;Prevention strategy;process evaluation;programs;Public Health;Quality of life;Race;racial population;Randomized;Randomized, Controlled Trials;Research;Risk;sedentary;socioeconomics;standard of care;Stress;Teenagers;Time;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Obesity is associated with “metabolic inflexibility”, which is involved in the pathophysiology of obesity-induced metabolic abnormalities, such as type 2 diabetes and insulin resistance. The proposed studies aim to understand the mechanisms of obesity-induced metabolic flexibility and develop new obesity treatment by using genetically engineered mouse models, cell culture system, and human adipose tissue biopsy samples.

PI_NAMEs: KLEIN, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Acetylation;Adipocytes;Adipose tissue;Adrenergic Agents;Anabolism;Biology;Biopsy Specimen;Blood specimen;Body Weight decreased;Calories;caveolin 1;Cell Culture System;Clinical;clinically relevant;Coenzymes;Data;Dependovirus;Diet;dietary restriction;Energy Metabolism;Enhancers;Enzymes;Exercise;exercise training;feeding;flexibility;Foundations;Functional disorder;Funding;Genetic;Genetically Engineered Mouse;glucose metabolism;Grant;High Fat Diet;Human;Impairment;improved;In Vitro;indexing;insight;Insulin Resistance;insulin sensitivity;insulin signaling;Knockout Mice;Life Style Modification;Link;Liver;Lysine;Mediating;Mediator;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Molecular;mouse model;Mus;Nicotinamide adenine dinucleotide;Nicotinamide Mononucleotide;nicotinamide phosphoribosyltransferase;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;Obesity;obesity treatment;Organ;overexpression;Overweight;Oxidation-Reduction;Persons;pharmacologic;Physiological;Placebos;PPARG gene;Prediabetes syndrome;response;Risk;Rodent;Series;Sirtuins;Skeletal Muscle;Supplementation;System;Tamoxifen;Testing;therapeutic target;Thermogenesis;Tissues;Visceral

PROJECT_TITLE: NAD+ and metabolic flexibility

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


NIH_SPENDING_CATS: Diabetes;Genetics;Obesity

ORG_STATE: MD

PHR: NARRATIVE Loss of mitochondria and oxidative capacity have been implicated in the development or progression of many diseases, from type 2 diabetes to cardiovascular diseases and skeletal muscle diseases. Understanding the mechanisms by which adipose cells respond to physiological signals, such as adrenergic stimulation, to build more mitochondria and higher capacity to oxidize nutrients, can present new ways for intervention in diseases associated with decreased oxidative capacity.

PI_NAMEs: KRALLI, ANASTASIA  (contact)

PROJECT_TERMS: adipocyte biology;Adipocytes;Adipose tissue;Adrenergic Agents;Adrenergic Agonists;Biogenesis;Bioinformatics;Biology;Body Temperature;Brown Fat;Cardiovascular Diseases;Cell Physiology;Cell Respiration;cell type;Cells;Code;Coupled;Cytoplasm;Defect;Development;Disease;Environment;ERR1 protein;estrogen-related receptor;Family;Functional disorder;gain of function;Gene Expression;gene induction;Genes;Genetic Transcription;Genome;Goals;Grant;Health;Heart;Homeostasis;Human;insight;Insulin Resistance;insulin sensitivity;Intervention;Kidney;Lead;lifestyle intervention;Link;Lipids;Liver;loss of function;member;Messenger RNA;Metabolic;Metabolism;Mining;Mitochondria;Mitochondrial Proteins;Molecular;mouse model;Mus;Myopathy;Nature;Non-Insulin-Dependent Diabetes Mellitus;Norepinephrine;novel;Nuclear;Nuclear Orphan Receptor;Nuclear Receptors;Nutrient;Obesity;Obesity associated disease;Organelles;overexpression;oxidation;Oxidative Phosphorylation;Pathway interactions;Pattern;Peroxisome Proliferator-Activated Receptors;pharmacologic;physiologic stressor;Physiological;Physiology;Post-Transcriptional Regulation;posttranscriptional;Proteins;Publishing;receptor;Receptor Signaling;recruit;Regulation;Regulator Genes;Regulatory Element;response;Role;Signal Transduction;Skeletal Muscle;Tertiary Protein Structure;Testing;Therapeutic Intervention;Thermogenesis;Tissues;trait;transcription factor;Transcriptional Regulation;Work

PROJECT_TITLE: Regulators of adipocyte oxidative metabolism

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Dysfunction to insulin secreting cells causes diabetes. Insulin-secreting cells show extensive electrical communication to regulate insulin secretion, and this communication is disrupted during diabetes. Understanding how this electrical communication is disrupted in diabetes will identify targets for retaining normal electrical communication and insulin secretion, thus providing potential drug targets for diabetes prevention.

PI_NAMEs: BENNINGER, RICHARD KP (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Actins;Address;Affect;Animal Model;Beta Cell;Binding;blood glucose regulation;C-terminal;Cell Death;Cell membrane;Cell Physiology;cell type;Cells;Communication;Compensation;Coupling;Cyclic AMP;cytokine;Cytoskeleton;Diabetes Mellitus;Diabetes prevention;diabetic;diabetogenic;Disease;Disease Progression;Drug Targeting;Endocrine;Functional disorder;Funding;gap junction channel;Gap Junctions;Genetic Transcription;Glucose;Goals;Hormones;Human;imaging approach;improved;Inflammatory;Insulin;insulin regulation;Insulin Resistance;insulin secretion;intercellular communication;islet;Islets of Langerhans;Knowledge;live cell imaging;Measures;Mediating;Microtubules;Molecular;mouse model;Nonesterified Fatty Acids;NPAS4 gene;nuclear factors of activated T-cells;Pathway interactions;Pattern;Permeability;Persons;Phosphorylation Inhibition;Physiological;Play;Prediabetes syndrome;preservation;prevent;programs;Proteins;RAS Superfamily Proteins;Regulation;Research;response;Role;Signal Transduction;Testing;therapeutic target;Time;trafficking;Work

PROJECT_TITLE: Gap Junction Communication and Islet Function in Diabetes

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Project Narrative The proposed project will determine the mechanisms that control pancreatic -cell endoplasmic reticulum (ER) Ca2+ (Ca2+ER) handling and their importance regulating islet hormone secretion. Results from this project are expected to provide significant insights into how glucose-stimulated-cell Ca2+ER handling becomes disrupted in T2D and perturbs islet hormone secretion. Thus, the proposed research project will generate fundamental knowledge about human islet -cells that will help reduce the burden of human illness in the context of diabetes.

PI_NAMEs: JACOBSON, DAVID AARON (contact)

PROJECT_TERMS: Ablation;Amino Acids;Animal Disease Models;blood glucose regulation;Calcium-Sensing Receptors;Cell Physiology;Cells;Coupled;Cytoplasm;D Cells;Data;Diabetes Mellitus;diabetes pathogenesis;diabetic;Disease;Dominant-Negative Mutation;driving force;Endoplasmic Reticulum;experimental study;Functional disorder;G alpha q Protein;G-Protein-Coupled Receptors;gain of function mutation;Glucagon;Glucose;Goals;Homeostasis;Hormone secretion;Human;insight;Insulin;insulin secretion;islet;Islets of Langerhans;knock-down;Knowledge;Laboratory Finding;maturity onset diabetes of the young;Mediating;Medical;Membrane Potentials;Molecular;Mus;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Pancreas;Pancreatic delta Cell;Pathogenesis;Pathway interactions;Patients;pharmacologic;Physiological;Population;Potassium Channel;receptor;Receptor Signaling;Research;Research Project Grants;response;Role;Signal Transduction;small hairpin RNA;Somatostatin;Stress;Testing;Transgenic Mice

PROJECT_TITLE: Molecular Mechanisms Regulating Pancreatic Delta Cell Function and Dysfunction

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE Obesity is an inflammatory condition that remains a universal contributor to type 2 diabetes. During the last grant award cycle, we defined pathways that temper the effects of inflammation on insulin sensitivity in obesity. After the next five years, we will know why certain inflammatory signals couple obesity with type 2 diabetes.

PI_NAMEs: HARTIG, SEAN  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Acetates;Adipocytes;Adipose tissue;Adverse effects;Anti-Inflammatory Agents;Aspartoacylase;Award;Binding Proteins;Binding Sites;Body Composition;Body mass index;Brain;carbohydrate metabolism;Carbon;cell type;Chronic;clinical efficacy;comorbidity;Complex;Coupled;cytokine;Cytoplasm;Data;Diabetic mouse;DNA Binding;Educational process of instructing;energy balance;Energy Metabolism;Enzymes;Exposure to;fatty acid metabolism;Feedback;Gene Expression;Genes;Genetic Transcription;Genomics;Goals;Grant;High Fat Diet;Human;Hyperglycemia;IFNGR1 gene;Immune system;Immunotherapy;improved;Inflammation;Inflammatory;Inflammatory Response;insight;Insulin Resistance;insulin sensitivity;Interferon Type II;Knock-out;Knowledge;Link;lipid biosynthesis;lipid metabolism;Lipids;Measures;Mediating;Metabolic;metabolic fitness;Metabolism;metabolomics;Methods;Mitochondria;mitochondrial dysfunction;Molecular;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Obese Mice;Obesity;obesity treatment;Oligodendroglia;Outcome;Overnutrition;Oxidative Phosphorylation;Pathogenicity;Pathway interactions;Phenotype;programs;Receptor Signaling;Repression;Research;response;Rodent;Role;Signal Transduction;STAT1 gene;Stress;Testing;Therapeutic;Tissue Expansion;transcription factor;Transcriptional Activation;Transcriptional Regulation;transcriptome sequencing;transmission process;Weight Gain

PROJECT_TITLE: Metabolic Impacts of Type II Interferon Signals in Obesity


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Dysfunction and death of the insulin-producing β-cell underlies virtually all forms of diabetes, and the protection of β-cells represents an approach to the treatment of diabetes that has yet to be exploited. The 12-LOX pathway represents an attractive target for protection of β-cells, since inhibitors of this pathway have been developed. This proposal will provide a better understanding of how the 12-LOX pathway can be manipulated to protect β-cells.

PI_NAMEs: KULKARNI, ROHIT N.;MIRMIRA, RAGHAVENDRA G (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Abdomen;acid stress;Acids;Active Sites;Adverse effects;Affinity;Applications Grants;Arachidonate 12-Lipoxygenase;Award;Beta Cell;Biology;Cell Line;Cell Physiology;Cells;Cessation of life;Characteristics;Chemicals;Collaborations;conditional knockout;Diabetes Mellitus;Eicosanoids;endoplasmic reticulum stress;Enzymes;Exhibits;expectation;Family;Functional disorder;Funding;G-Protein-Coupled Receptors;Gene Deletion;Genes;Genetic Models;GPR31 receptor;Growth Factor;Human;Human Biology;humanized mouse;Image;Imaging Device;impaired glucose tolerance;in vivo;in vivo Model;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;innovation;insight;Insulin;Insulin Resistance;insulin signaling;Intervention;intravital imaging;islet;Knock-in Mouse;Knock-out;Knockout Mice;Link;Lipids;Lipoxygenase;Mediating;Modeling;Molecular;mouse model;Mus;novel;Obesity;Oxidative Stress;Paper;Pathway interactions;Phase;Polyunsaturated Fatty Acids;pre-clinical;Productivity;Protein Isoforms;Publications;Reagent;receptor;receptor-mediated signaling;release of sequestered calcium ion into cytoplasm;Research Personnel;Role;Signal Transduction;Small Business Technology Transfer Research;System;Testing;Therapeutic;therapeutic target;Time;tool;two-photon;type I and type II diabetes;Validation;virtual;Work

PROJECT_TITLE: Role of 12-lipoxygenase and 12-HETE signaling in beta-cell dysfunction

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Chronic Kidney Disease is predominantly a result of initial injury to the glomerulus, the filtration system in the kidney. Dysregulated signaling between injured visceral and parietal epithelial cells is a major contributor to glomerular dysfunction and eventual kidney failure. In this research proposal, we aim to investigate the mechanisms mediating this cellular crosstalk in glomerular disease.

PI_NAMEs: HE, JOHN CIJIANG;MALLIPATTU, SANDEEP K (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Actins;Address;American;Attenuated;Binding;Cell Adhesion;Cell Cycle;Cell Cycle Checkpoint;Cell Differentiation process;cell type;Cellular Stress;ChIP-seq;Chronic Kidney Failure;comparison control;Cytoskeleton;Data;Development;differential expression;Differentiation Antigens;Disease;druggable target;Epithelial Cell Proliferation;Epithelial Cells;Failure;Family;Feedback;Filtration;Focal and Segmental Glomerulosclerosis;Functional disorder;Genes;GKLF protein;glomerulosclerosis;Goals;healthcare burden;Human;Hyperplasia;injured;Injury;Injury to Kidney;innovation;Kidney;kidney biopsy;Kidney Failure;Kidney Glomerulus;knock-down;Kruppel-like transcription factors;Laboratories;Lesion;Ligands;Maintenance;Mediating;Mediator;member;migration;Mitotic;Modeling;mouse model;Mouse Strains;Mus;mutant;Mutate;novel;Organoids;paracrine;Paracrine Communication;Parietal;Pathogenesis;Pathway interactions;Play;podocyte;postmitotic;Predisposition;prevent;Prevention;Proliferating;Proteomics;Rapidly Progressive Glomerulonephritis;receptor;Receptor Activation;Regulation;Renal glomerular disease;Reporting;Research Proposals;Role;Signal Induction;Signal Transduction;single nucleus RNA-sequencing;Specimen;Stat3 protein;System;Testing;therapeutic target;transcription factor;transcriptome sequencing;United States;Variant;Visceral;Zinc Fingers

PROJECT_TITLE: Mechanisms mediating podocyte-parietal epithelial cell crosstalk in proliferative glomerulopathies

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Autoimmune Disease;Lupus;Prevention

ORG_CITY: Oklahoma City

ORG_NAME: PROGENTEC DIAGNOSTICS, INC.

ORG_STATE: OK

PHR: PROJECT NARRATIVE Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease which causes significant morbidity and early mortality, especially in young minority women. SLE patients are at risk for ongoing heightened clinical disease activity and disease flares that often result in end-organ damage, and are only identified after clinical signs and symptoms have occurred. We propose to validate and prepare advanced marketing/clinical adoption and reimbursement strategies for a select panel of blood proteins that are known to activate or regulate the immune system and feed the results into innovative mathematical algorithms that assign a single, immune system-informed and clinically actionable disease activity or flare prediction scores to provide proactive information as to which SLE patients are likely to have heightened clinical disease activity or who are at risk of imminent disease flare (positive score) for early intervention, organ damage prevention, and reduced need for treatments that carry damaging side effects.

PI_NAMEs: MUNROE, MELISSA E (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Adoption;Algorithms;anti-dsDNA antibodies;Autoimmune Diseases;Biological;Biological Markers;Biological Response Modifiers;Blood Proteins;Blood Tests;Chronic;Clinic;Clinical;Clinical assessments;clinical risk;Clinical Trials;clinically actionable;Code;cohort;Collaborations;commercialization;commercialization readiness;Communities;community setting;Companions;Complement;Complex;Continuity of Patient Care;Current Procedural Terminology Codes;design;Diagnostic tests;disabling symptom;Disease;Disease Management;Early identification;Early Intervention;Early treatment;ethnic diversity;Exhibits;experience;Flare;Funding;Funding Mechanisms;Future;Goals;Immune;Immune system;Immunoassay;immunological status;Immunology;improved;indexing;Industry;Inflammation;innovation;instrument;Intervention;Letters;Lupus;Managed Care;Market Research;Marketing;mathematical algorithm;Measurement;Measures;minority children;Minority Women;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Organ;Pathway interactions;Patients;Perception;Pharmaceutical Preparations;Phase;Plasma;Positioning Attribute;Preparation;prevent;Prevention;prospective;prototype;Quality of life;Reporting;Research;research and development;research clinical testing;Research Design;Research Personnel;rheumatologist;Rheumatology;Risk;Sampling;Serology;side effect;Signal Transduction;Signs and Symptoms;Small Business Innovation Research Grant;Specificity;Steroids;success;systemic autoimmune disease;Systemic Lupus Erythematosus;tertiary care;Testing;Time;Tissues;Toxic effect;Treatment Protocols;Validation;Visit;Waxes;Work

PROJECT_TITLE: Commercialization Readiness of Immune Mediator Based Blood Tests that Inform Concurrent and Future Clinical Disease Activity in Systemic Lupus Erythematosus (SLE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (19)]


ORG_CITY: ATLANTA

ORG_DEPT: NEUROSURGERY

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Approximately one third of patients with temporal lobe epilepsy do not respond to currently available antiseizure drugs, and many are not candidates for surgical resection. Inhibition of activity of a specific cell type in the hippocampus effectively arrests seizures in a rodent model of temporal lobe epilepsy, but translation of this approach is being hampered by the inability to specifically target these cells in human patients as it is impossible to modify genes as in model animals. In this project we will develop a viral vector to specifically deliver a transgene to the hippocampus in non-genetically modified mice with the goal of developing a novel and translatable gene therapy to stop seizures in patients with drug-resistant temporal lobe epilepsy.

PI_NAMEs: GROSS, ROBERT E (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Adult;Alternative Therapies;alternative treatment;Alzheimer's Disease;Animal Model;anti-cancer research;Anticonvulsants;Area;Astrocytes;awake;Award;axonal sprouting;behavioral study;Brain;Calcium;calcium indicator;cell type;Cells;Clinical;Collaborations;Color;dentate gyrus;detection method;Development;Disease;disease model;Disease Progression;Drug resistance;efficacy evaluation;Electroencephalography;Electrophysiology (science);Ensure;Environment;Epilepsy;Event;Excision;excitatory neuron;experience;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;expression vector;extracellular;Face;Fiber;Foundations;Frequencies;Funding;gene therapy;gene-targeted therapy;Genes;Genetic;Genomic Segment;Glutamates;Goals;granule cell;Hippocampal Formation;Hippocampus;Homeobox;Homeodomain Proteins;Human;improved;Injections;innovation;insight;International;Intervention;Intractable Epilepsy;Japan;Kainic Acid;Laboratories;Light;Lymphatic Research;medial temporal lobe;Mediating;Modality;Modeling;Molecular;Molecular Neurobiology;Monitor;Morphology;mouse model;Mus;Nervous System Disorder;Neuroglia;Neurons;neuropsychiatric disorder;neuroregulation;new technology;nonhuman primate;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;Opsin;Parents;Patients;Photometry;Physiology;Play;Population;prevent;Primates;promoter;Proteins;Pyramidal Cells;receptor;Recurrence;Regulation;Research;Resistance;Rodent;Rodent Model;Role;Seizures;selective expression;side effect;Signal Pathway;Temporal Lobe;Temporal Lobe Epilepsy;Testing;therapy development;tool;Transgenes;Transgenic Animals;Transgenic Mice;translational approach;translational potential;Validation;Viral Vector

PROJECT_TITLE: Collaborative Research Fund: Development and validation of a viral vector for targeted inhibition of DG granule cells


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: DOVER

ORG_NAME: DELAWARE STATE UNIVERSITY

ORG_STATE: DE

PHR: Identifying Needs and Building Research Capacity at an Historically-Black University Public Health Relevance  Building research capacity at Historically-Black institutions such as Delaware State University is a strategic investment that not only benefits these institutions, but also contributes to the advancement of scientific knowledge, the reduction of health disparities, and the promotion of diversity and inclusion in research. Building research capacity at HBCUs enables them to conduct research that addresses the unique health needs of their communities, contributing to the reduction of health disparities.

PI_NAMEs: HARRINGTON, MELISSA A (contact);MURRAY-JACKSON, LYNDA HOPE;SUDLER, KIMBERLEY RENEE

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: academic program;Accounting;Address;Administrator;African American;African American population;Area;Benchmarking;Biomedical Research;career;career development;Chemistry;Classification;college;Communities;Dedications;Delaware;Development;diversity and inclusion;Doctor of Philosophy;Effectiveness;Enrollment;Ensure;Environment;experience;Faculty;faculty support;Fostering;Funding;Goals;graduate school;Grant;Growth;Health;health disparity;Historically Black Colleges and Universities;Human Resources;improved;Individual;Infrastructure;innovation;Institution;Interview;Investments;Knowledge;Leadership;Mathematics;Medicine;member;Mentorship;Mission;Needs Assessment;Neurosciences;operation;Play;Population;process improvement;Program Reviews;programs;public health relevance;Recording of previous events;Reduce health disparities;Research;Research Activity;research and development;Research Personnel;Research Project Grants;Research Support;Resources;Role;Science;Scientific Advances and Accomplishments;Services;Site;Strategic Planning;Structure;Students;success;Support System;Thinness;Time;Training;undergraduate research;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;University adminstration;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 XLN (M1)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: EDINBURG

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

PHR: Project Narrative Health research is vital to improving community health and is most effective when conducted synergistically between medical and health professionals (allied health, nursing, social work, clinical psychology) who represent more than 80% of the healthcare workforce. Closing the significant gap in the level of research skills and engagement between medical and health professions is critical to accelerating progress in addressing the most complex challenges on the public health agenda. The successful implementation of the proposed research needs assessment and corresponding action plan will result in an effective model that will support a robust multidisciplinary, interprofessional research capacity to advance health and health disparities research at minority-serving, resource-limited institutions.

PI_NAMEs: LEHKER, MICHAEL W. (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Acceleration;Address;Ally;Behavioral Sciences;biomedical profession;Biomedical Research;Clinical;Clinical Psychology;Clinical Sciences;Communities;Community Health;Complex;Continuity of Patient Care;Critical Pathways;Data;Data Analyses;Discipline of Nursing;disorder prevention;economic disparity;Education;Educational process of instructing;Elements;Ensure;Environment;Evaluation;Evidence based practice;Factor Analysis;Faculty;faculty research;Feedback;Focus Groups;Fostering;Foundations;Funding;Future;Goals;Health;health care availability;Health Disparities Research;health disparity;Health Occupations;Health Professional;Healthcare;Height;Hispanic;Hispanic-serving Institution;improved;Individual;Infrastructure;Institution;Institutional Policy;Interview;Knowledge;Latino;Measurable;Medical;medically underserved;Mexico;Minority;minority health;minority health disparity;Mission;model building;Modeling;multidisciplinary;Nature;Needs Assessment;Outcome;Patient Care;Policies;poor health outcome;Positioning Attribute;Poverty;Procedures;Productivity;Professional Practice;Psychological Factors;Public Health;recruit;Research;research faculty;Research Infrastructure;Research Support;Resources;Scanning;Science;skills;social factors;social health determinants;Social Sciences;Social Work;South Texas;Structure;Students;success;Surveys;Testing;Texas;Training;Underrepresented Students;underserved area;underserved community;Underserved Population;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Reaching New Heights: Strengthening Health Professions Research at a Majority Hispanic-Serving Institution


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PI_NAMEs: AHALT, STANLEY CARLTON (contact);KRISHNAMURTHY, ASHOK KUMAR

PROGRAM_OFFICER_NAME: BECK, TYLER

PROJECT_TERMS: Acceleration;Address;adverse outcome;Algorithms;application programming interface;autoencoder;Automobile Driving;Award;Bayesian neural network;Binding;Clinical;clinical care;cohort;Computational algorithm;Data;Data Analyses;data sharing;design;Etiology;Event;Funding;Goals;Infrastructure;innovation;insight;Institution;Institutional Review Boards;Knowledge;machine learning method;Methods;Modeling;Modification;Multivariate Analysis;Neural Network Simulation;Pathway interactions;patient mobility;patient privacy;preservation;Privacy;Protocols documentation;prototype;Provider;Rare Diseases;recurrent neural network;Research;Schools;Secure;Security;Services;spatiotemporal;Specificity;Statistical Algorithm;Statistical Methods;Time;tool;Translational Research;Work

PROJECT_TITLE: ICEES+ Knowledge Provider: Leveraging Open Clinical and Environmental Data to Accelerate and Drive Innovation in Translational Research and Clinical Care.


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: BIRMINGHAM

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PI_NAMEs: BYRD, WILLIAM E (contact);MIGHT, MATTHEW BRENDON

PROJECT_TERMS: Autonomous Relay Agent;precision medicine

PROJECT_TITLE: Doc Sherlock: An Autonomous Relay Agent for Discovering the  "Unknown Knowns" in Precision Medicine


NIH_SPENDING_CATS: Data Science

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PI_NAMEs: SANTOS, EUGENE  (contact)

PROJECT_TITLE: Pathway Hypotheses Knowledge-base: A Knowledge Source for the Biomedical Data Translator


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

PI_NAMEs: TROPSHA, ALEXANDER  (contact)

PROJECT_TERMS: Autonomous Relay Agent;Generations

PROJECT_TITLE: ARAGORN: Autonomous Relay Agent for Generation Of Ranked Networks