ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: CORAL GABLES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Retinal ischemia-reperfusion (IR) injury is a common clinical condition, which results in necrotic and apoptotic retinal ganglion cell (RGC) death. However, significant attention has been given to IR-induced apoptosis, which can be regulated, but not to necrosis, because it had been viewed as an accidental and unregulated cellular event. We now know that this viewpoint was incorrect and programmed (as opposed to accidental) RGC necrosis can significantly contribute to IR-induced retinal injury through signaling cascades, which will be investigated in detail in the proposed study.

PI_NAMEs: IVANOV, DMITRY V (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;Accidents;Affect;Animal Model;Apoptosis;Apoptotic;Attention;Binding;Biochemical;Biological;CASP8 gene;Caspase;Cell Death;Cell membrane;Cell Survival;cell type;Cells;Clinical;Complex;Data;Deubiquitination;DNA Damage;Event;experimental study;Failure;Feedback;Functional disorder;functional status;Genetic;Induction of Apoptosis;Inflammatory Response;Injury;Ischemia;Literature;MAPK8 gene;Mediating;Mediator;Membrane;Mitochondria;Molecular;Molecular Conformation;multicatalytic endopeptidase complex;NADPH Oxidase;Necrosis;Neurons;neurotoxic;novel therapeutic intervention;Osmosis;oxidative DNA damage;Oxidative Stress;Pathway interactions;Patients;Poly(ADP-ribose) Polymerases;Polymerase;prevent;Production;Proteins;Published Comment;Publishing;Quality of life;Reactive Oxygen Species;Reperfusion Injury;Reperfusion Therapy;Research;Respiration;response;Retina;retinal damage;Retinal Degeneration;Retinal Ganglion Cells;retinal ischemia;retinal neuron;retinal stimulation;Role;Signal Transduction;Swelling;Techniques;Testing;Time;TNF gene;Tumor Necrosis Factor Receptor;Ubiquitination;Vision;Visual impairment

PROJECT_TITLE: Molecular mechanisms of programmed necrosis in the ischemic retina

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Data Science;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Rural Health;Telehealth

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PI_NAMEs: SIMOES, EDUARDO J (contact)

PROJECT_TERMS: Acceleration;Address;Advanced Development;Algorithms;analytical tool;Big Data;Caring;Collaborations;Communities;Complex;complex data;Consultations;COVID-19 pandemic;Data;Data Analytics;data infrastructure;Data Set;Diabetes Mellitus;diabetes risk;digital;Disparity;Disparity population;eHealth;Ensure;Environment;Equity;evidence base;Health;health application;health care service organization;health equity;health goals;health information technology;health management;Health Services Accessibility;Health Technology;Healthcare;heterogenous data;improved;Inequity;Informatics;innovation;instrument;Internet;Intervention;Libraries;meetings;Methodology;mHealth;Missouri;Outcome;Policies;Populations at Risk;programs;Public Health Informatics;Research;Research Personnel;Research Priority;Resources;response;Rural Community;Rural Population;Science;sensor;Services;Site;socioeconomic disadvantage;Source;Stream;Technology;telehealth;Translating;translational progress;Translational Research;Universities;usability;Washington

PROJECT_TITLE: HIDR - Health Informatics in Diabetes Research


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rural Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Environmental heat exposure can have significant health consequences. In particular agricultural workers experience heat-related mortality at a rate 35 times greater than that of the overall US workforce. Through this study we aim to develop biopatch and associated software that can process signals from multiple sensors to generate warning alerts prior to development of symptoms of heat-related illness or dehydration.

PI_NAMEs: HERTZBERG, VICKI STOVER (contact);XIONG, LI ;YEO, WOON-HONG

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Accounting;Acute;Adverse effects;Adverse event;adverse outcome;Affect;Agricultural Workers;Android;Assessment tool;Biological Markers;Biomedical Engineering;Biosensor;Blood;Bluetooth;Body Temperature;Chronic;climate change;Computational algorithm;computer science;Computer software;Confusion;Data;data integration;Data Science;data streams;Dehydration;Detection;Development;Devices;Discipline of Nursing;Dizziness;Electrocardiogram;Electrolytes;Environment;Epidemiology;Equipment;Evaluation;evaporation;experience;Exposure to;extreme heat;Feedback;Feeds;field study;Florida;Future;Generations;Goals;Headache;Health;health assessment;Heart Rate;Heat Stress Disorders;high risk;Hydration status;Immigrant;Impairment;Individual;innovation;Intervention;Intervention Studies;Judgment;Latin America;Learning;Machine Learning;machine learning algorithm;marginalized population;Measures;medical attention;medically necessary care;Methods;Modality;Modeling;Monitor;Morbidity - disease rate;mortality;Motion;multi-task learning;multidisciplinary;multimodality;Muscle Cramp;nanoengineering;Nanomanufacturing;nanomaterials;nanomembrane;nanoscale;Nature;Nausea;network models;novel;Occupational;Occupational Exposure;Outcome;Oxygen;Pattern;Performance;Persons;Physiologic Monitoring;Physiological;Physiology;predictive modeling;prevent;Printing;privacy preservation;Process;Protocols documentation;prototype;Public Health;real world application;recruit;Reporting;Research Personnel;respiratory;response;Risk;sensor;shift work;Signal Transduction;Skin;Skin Temperature;Software Tools;Sweating;Symptoms;Syncope;System;Technology;Temperature;Testing;therapy development;Time;transmission process;trend;Universities;Vomiting;wearable device;Weather;wireless;Work

PROJECT_TITLE: Sensor Hardware and Intelligent Tools for Assessing the Health Effects of Heat Exposure

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project narrative. Protein allostery, in which a perturbation at one site in a protein causes a functional change at a distal site, is fundamental to biological information transfer but challenging to engineer. This proposal establishes a platform that combines high-throughput biophysical characterization of perturbation-driven dynamics with precise computational design to discover disease mechanisms and design new allosteric therapeutics and drugs.

PI_NAMEs: GLASGOW, ANUM AZAM (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: 6-Phosphofructokinase;Affect;Allosteric Regulation;Allosteric Site;Behavior;Binding;Binding Sites;Biochemical;Biological;biophysical properties;biophysical techniques;Biophysics;Biosensor;Buffers;Calorimetry;Complex;Computing Methodologies;Consumption;Coupling;Data;design;Deuterium;Disease;disease diagnosis;Distal;DNA;DNA Binding;Drug Design;Engineering;Environment;Enzymes;Equilibrium;Escherichia coli;Eukaryota;Evolution;Exhibits;experimental study;Family;Feedback;Foundations;Gatekeeping;Gene Expression;Gene Library;Glycolysis;Goals;high throughput screening;Homologous Gene;Homologous Protein;Human;human disease;Hydrogen;Hydrogen Bonding;improved;Individual;innovation;Interferometry;Knowledge;Laboratories;Lac Repressors;large datasets;Learning;Libraries;Ligand Binding;Ligands;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measurement;Mediating;member;Mentors;Mentorship;method development;Methods;Molecular Conformation;Motion;Movement;Mutagenesis;Mutagens;mutant;Mutation;mutation screening;novel strategies;novel therapeutics;Peptides;Pharmaceutical Preparations;Phase;Postdoctoral Fellow;programs;Protein Conformation;Protein Engineering;Protein Family;Protein Isoforms;Proteins;Regulation;repaired;Research;response;sensor;Signal Transduction;simulation;Site;skills;small molecule;Solvents;Specificity;Structure;sugar;System;Techniques;Testing;Therapeutic;therapeutic protein;Time;Titrations;Toxic effect;Training;transcription factor;United States National Institutes of Health;Water;Work

PROJECT_TITLE: Mapping and rewiring protein allostery


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Congenital Structural Anomalies;Digestive Diseases;Genetics;Liver Disease;Organ Transplantation;Orphan Drug;Pediatric;Rare Diseases;Transplantation

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Bile duct paucity can be cured by liver transplantation, but this therapy is hampered by a shortage of donor organs and by potential side effects of long-term immunosuppressive therapy, especially in children. The proposed preclinical studies examine whether enhancing the biliary system in a mouse model of a pediatric liver disease can rescue bile duct paucity, setting the stage for developing a therapy to avoid or postpone liver transplantation in patients.

PI_NAMEs: HUPPERT, STACEY S;JAFAR-NEJAD, HAMED  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Address;Adverse effects;Affect;Age;Alagille Syndrome;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Area;autosomal dominant mutation;Bile Acids;bile duct;Bile Duct Diseases;Bile fluid;Biliary;biliary tract;Binding;Body System;Bypass;Cardiovascular system;cell type;Characteristics;Child;Childhood;Cholestasis;Clinical;clinical care;Clinical Research;Collaborations;Data;Development;developmental disease;Disease;dominant genetic mutation;dosage;end stage liver disease;Exclusion;Foundations;Frequencies;Genes;Genetic;Genetic Models;glycosyltransferase;Goals;Government;Hepatocyte;Heterozygote;Immune;improved;Industry;industry partner;inhibitor;intrahepatic;Intrahepatic bile duct;Kidney;knock-down;Knowledge;Ligands;Liver;Liver diseases;liver injury;liver transplantation;Long-Term Effects;Mediating;Medical;Modeling;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;notch protein;Notch Signaling Pathway;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Organ;Organ Donor;Other Genetics;Pathway interactions;patient population;Patients;Persons;Pharmacologic Substance;Phenotype;Plant Resins;Portal vein structure;postnatal;preclinical study;Pruritus;Publishing;Regulation;Reporting;Research;Severities;side effect;System;targeted treatment;Therapeutic;Therapeutic immunosuppression;therapy development;Time;transcription factor;Transplantation;Treatment Efficacy;treatment strategy;Waiting Lists;Work

PROJECT_TITLE: Targeting POGLUT1 to promote biliary development in Alagille syndrome


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WHITT-GLOVER, MELICIA C (contact)

PROJECT_TERMS: Address;Affect;Attention;Black American;Black Populations;Black race;black/white disparity;Body Weight decreased;Case Study;Civil Rights;Communities;community based research;community partnership;Consultations;Country;COVID-19 disparity;COVID-19 incidence;COVID-19 pandemic;Criminal Justice;Databases;Dedications;Dependence;diabetes control;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;disease transmission;Disparity;distrust;Economics;Education;effective intervention;Effectiveness;Effectiveness of Interventions;Employment;Epidemiology;experience;Exposure to;Food;Funding;Goals;Growth;Health;health care availability;health disparity;health disparity populations;Health Insurance;Health Policy;Health Professional;Healthcare Systems;Housing;improved;International;Intervention;Knowledge;Low income;Measurement;member;Methodology;Mission;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity prevention;obesity treatment;Occupations;online resource;Pennsylvania;Physical activity;Police;Policies;Population Heterogeneity;Racial injustice;Racial Segregation;Recommendation;Research;Research Personnel;Research Proposals;Resources;Risk Factors;Services;Shelter facility;Sick Leave;social;social health determinants;stem;Structural Racism;System;tool;Translating;Translational Research;Typology;Universities;virtual group;Wages;Washington;Weight maintenance regimen

PROJECT_TITLE: SDBA-Solutions to Diabetes in Black Americans


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Despite the widespread use of combination antiretroviral therapy, the prevalence of chronic kidney disease and end-stage kidney disease continues to remain high in patients living with HIV, suggesting that HIV predisposes patients to increased risk for chronic kidney disease. The current proposal will explore how HIV-1 accessory protein Vpr causes kidney tubular cell injury and promotes kidney disease progression in HIV-infected individual, and knowledge gained will allow for development of more effective therapies for HIV-associated kidney disease.

PI_NAMEs: HE, JOHN CIJIANG;KLOTMAN, MARY E.;LEE, KYUNG  (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Acceleration;Age related comorbidities;AIDS-Associated Nephropathy;Animal Model;Anti-Retroviral Agents;Antimitotic Agents;antiretroviral therapy;Apoptosis;Apoptotic;Atrophic;Attenuated;Biopsy Specimen;Bypass;cancer cell;CDC2 gene;CDT1 Gene;Cell Cycle;Cell Cycle Arrest;Cell Cycle Deregulation;Cell Death;cell injury;Cells;Cessation of life;Chromatin;Chronic;Chronic Kidney Failure;Clinical;comparative;Complement;Cytokinesis;Defect;Development;Diabetes Mellitus;Diagnosis;Disease Progression;DNA biosynthesis;DNA Replication Factor;effective therapy;End stage renal failure;epidemiological model;Epithelial Cells;Equilibrium;Fibrosis;G2/M Arrest;Gene Expression;Genes;HIV;HIV Infections;HIV therapy;HIV-1;Human;Hyperplasia;Hypertrophy;In Situ;In Vitro;in vivo;Incidence;Individual;Inflammation;inhibitor;Injury;Injury to Kidney;interstitial;Intervention;Kidney;kidney biopsy;Kidney Diseases;kidney fibrosis;Knowledge;Licensing;Licensing Factor;Measures;Mediating;Mitosis;Mitotic;Mitotic Cell Cycle;Modeling;Molecular;Monitor;mouse model;Mus;new therapeutic target;novel;Pathogenesis;Pathologic;Patients;pharmacologic;Phenotype;Phosphotransferases;PLK1 gene;Polyploid Cells;Polyploidy;premature;Prevalence;Proteins;Proteinuria;Reporter;Reporting;Risk;RNA;Role;single-cell RNA sequencing;Study models;Therapeutic Effect;Therapeutic Intervention;Time;TP53 gene;transcriptome sequencing;transcriptomic profiling;transcriptomics;Transgenic Mice;Tubular formation;Viral Load result;Viral Proteins;vpr Gene Products

PROJECT_TITLE: The role of Vpr-mediated cell cycle dysregulation in HIV-associated kidney disease


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE An important goal in psychiatric neuroimaging is to identify brain-behavior associations for the purpose of identifying biomarkers that are indicative of illness trajectory or inform our biological understanding of psychiatric disorders. The goal of this project is to develop a statistically robust framework to address the limitations of existing inference methods, which have highly inflated false positive rates in many situations. This study will impact public health by improving the rigor and replicability of statistical inference for neuroimaging studies so that results can more accurately inform our understanding of the biological underpinnings of psychiatric illness.

PI_NAMEs: VANDEKAR, SIMON NEIL (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TITLE: Semiparametric Inference for Psychiatric Neuroimaging

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Neurosciences;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Cochlear hair cell loss is a leading cause of noise-induced and age-related hearing loss worldwide. Although surrounding supporting cells show the capacity to produce hair cells in neonatal mice, this plasticity is lost by postnatal day 5. This grant proposes to examine transcription factors hypothesized to be important in maintaining supporting cell fate, with the goal of establishing a gene therapy strategy to regenerate hair cells in vitro.

PI_NAMEs: MORGAN, CHARLES  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Address;Affect;Aging;Applications Grants;Binding;Birds;cell dedifferentiation;Cell Differentiation process;cell injury;Cell Physiology;Cell Proliferation;Cell Reprogramming;cell type;Cells;Cochlea;cochlear development;Collection;Cues;developmental disease;Down-Regulation;epigenomics;Epithelium;experimental study;Exposure to;Family;Fishes;fluorescence imaging;Future;gain of function;Gene Expression Regulation;gene therapy;Genes;Genomic Segment;Goals;Grant;Growth;hair cell regeneration;Hair Cells;hearing impairment;Human;Image;In Vitro;in vivo;Knowledge;Link;loss of function;Maintenance;member;Metabolic;Missense Mutation;Modeling;Muller's cell;Mus;Neonatal;neonatal mice;Neuroglia;NFIA gene;noise exposure;Noise-Induced Hearing Loss;Organoids;ototoxicity;overexpression;Pathway interactions;Physiologic pulse;Population Heterogeneity;postnatal;Presbycusis;prevent;Primrose syndrome;Process;Production;progenitor;Regenerative capacity;regenerative cell;regenerative therapy;Reporter;response;Retina;retinal neuron;retinal regeneration;Role;Sensory;stem-like cell;Supporting Cell;System;Testing;Tissues;transcription factor;transcriptomics;Translational Research;Up-Regulation;Virus Diseases;Work

PROJECT_TITLE: The role of supporting cell de-differentiation in cochlear hair cell regeneration


NIH_SPENDING_CATS: Clinical Research;Diabetes

PI_NAMEs: REEDS, DOMINIC N (contact)

PROJECT_TERMS: Address;Area;Articulation;Award;Black race;Career Mobility;Collaborations;Communities;Cost Savings;Data;Department chair;Development;Diabetes Mellitus;disparity elimination;Eligibility Determination;Ensure;Evaluation;Feedback;Funding;Future;Goals;Grant;Health;health care settings;health equity;improved;innovation;Institution;interest;Intervention;Leadership;Measures;Medicine;meetings;member;Mentors;Mentorship;Mission;Missouri;Modeling;next generation;Population Heterogeneity;programs;Publications;Research;Research Design;Research Personnel;Research Support;Review Committee;Science;Societies;success;Time;Training;Training Activity;Translating;Translational Research;United States National Institutes of Health;Universities;Vision;Washington;Work;World Health

PROJECT_TITLE: PFP- Pilot & Feasibility Program


ADMINISTERING_IC: FD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA DEPT OF AGRICULTURE/FORESTRY

ORG_STATE: LA

PHR: Project Narrative Animal Feed Regulatory Program Standards (AFRPS) Maintenance and the Enhancement of Current Good Manufacturing Practices (cGMP) and Preventive Controls for Animal Food (PCAF) Regulatory Activities Funding under this Cooperative Agreement Grant, “Development and Maintenance of the Animal Feed Regulatory Program Standards with Optional Coordinated Preventive Control Regulatory Activities and Capacity Building (U18) Clinical Trial Not Allowed,” the Louisiana Department of Agriculture & Forestry’s (LDAF), Office of Animal Health & Food Safety, Feed Program Division will be able to maintain full conformance with the Animal Feed Regulatory Program Standards (AFRPS) and support the FDA Preventive Controls Initiative. The overall goal of this project is to develop the capability to maintain conformance to the AFRPS and conduct comprehensive feed inspections covered under 21 CFR Part 507, independent of but in coordination with the FDA. Maintaining full conformance with the AFRPS will assist both Louisiana and the Food and Drug Administration (FDA) to better direct their regulatory activities toward preventing feed manufacturing compliance issues and increasing food safety and Public Health within the United States.

PI_NAMEs: WAGUESPACK, CRAIG  (contact)

PROGRAM_OFFICER_NAME: ISAKSON, ISAIAH

PROJECT_TITLE: Animal Feed Regulatory Program Standards (AFRPS) Maintenance and the Enhancement of Current Good Manufacturing Practices (cGMP) and Preventive Controls for Animal Food Regulatory (PCAF) Activities


ORG_CITY: HARRISBURG

ORG_NAME: PENNSYLVANIA DEPARTMENT OF AGRICULTURE

ORG_STATE: PA

PHR: PA Department of Agriculture Project Narrative- PAR-20-132 Advance efforts for a nationally integrated food safety system by strategically enhancing our state feed safety program through the maintenance funding of the Animal Feed Regulatory Program Standards (AFRPS). By maintaining implementation of these program standards, the PA feed regulatory program can direct regulatory activities toward preventing animal feed safety hazards and responding to animal feed consumer complaints, recalls, investigations, and strategic risk planning surveillance. By maintaining the AFRPS, the animal feed program will be positioned to both lead or assist federal and other state agencies with emerging or present food safety issues. Project will be managed by Erin Bubb and David Dressler, both, full-time management.

PI_NAMEs: BUBB, ERIN  (contact)

PROGRAM_OFFICER_NAME: LITTRELL, KEITH

PROJECT_TITLE: AFRPS Maintenance


ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: AR

PHR: Project Narrative: The Arkansas Department of Agriculture (ADA) developed and implemented a comprehensive Produce Safety Program in the previous FDA Produce Safety Cooperative Agreement Program (PAR-16-137). The Program includes education, outreach, and technical assistance, and an intricate regulatory program comprised of inspections, compliance, and enforcement. The ADA will continue to build and advance the Program by accomplishing key milestones required of the objectives contained within the new CAP.

PI_NAMEs: STOLL, MARK  (contact)

PROGRAM_OFFICER_NAME: VARGO, ADRIANNA

PROJECT_TITLE: Path C The FDA's Cooperative Agreement Program for States and Territories to Implement a National Produce Safety Program.


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

PHR: Project Narrative ADNP is a homeodomain protein that when mutated causes ADNP syndrome. How ADNP regulates neuronal gene expression and the function of its homeodomain is largely unknown. Elucidating ADNP’s role in gene regulation will yield key insights into mechanisms underlying ADNP syndromes and other diseases with ADNP mutations.

PI_NAMEs: SARMA, KAVITHA  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: attenuation;autism symptoms;Binding;Biochemical;Biological Assay;Chromatin Structure;Data;Defect;Development;developmental disease;Disease;Ensure;Epitopes;ES Cell Line;Functional disorder;Gene Expression;Gene Expression Regulation;gene repression;Genome;genome-wide;homeodomain;Homeodomain Proteins;human disease;Impairment;In Vitro;in vivo;in vivo evaluation;insight;Intellectual functioning disability;Link;Malignant Neoplasms;Molecular;Mouse Embryonic Stem Cells;Mouse Protein;mutant;Mutate;Mutation;nerve stem cell;neurodevelopment;Neuronal Differentiation;Neurons;neuroprotection;novel;Nucleic Acid Binding;nucleic acid structure;Nucleic Acids;prevent;programs;Protein Deficiency;protein distribution;protein function;Proteins;Reagent;Regulation;Resolution;Ribonuclease H;RNA;Role;Site;Syndrome;Tertiary Protein Structure;Testing;Transcription Repressor;Zinc Fingers

PROJECT_TITLE: ADNP mechanisms in R-loop regulation during differentiation

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: American Indian or Alaska Native;Diabetes;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: HAIRE-JOSHU, DEBRA  (contact)

PROJECT_TERMS: Address;Alaska Native;American Indians;Awareness;Collaborations;Communities;community academic partnership;community organizations;community partners;design;Development;Diabetes Mellitus;Diabetes prevention;Discipline;Disparity;Educational Activities;efficacious intervention;Environment;Evaluation;Evaluation Research;Event;evidence base;Feedback;Fostering;Foundations;Future;Goals;Grant Review;Health;health equity;Health Professional;innovation;interest;Joints;Knowledge;Leadership;Learning;lectures;Link;Manuscripts;marginalized community;member;Mentors;Mentorship;minority investigator;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Obesity;Populations at Risk;post-doctoral training;Program Reviews;programs;Publishing;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;Science;Scientist;Series;skills;Strategic vision;Stream;Training;Training Activity;Training Programs;Translating;Translational Research;Underrepresented Minority;Universities;Washington;web platform;webinar;Work

PROJECT_TITLE: Enrichment Program


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: Suicidal behavior and schizophrenia (Sz) spectrum disorders are major public health problems affecting Veterans. Recent studies indicate that Veterans exhibit higher suicide risk compared with the general U.S. population. Recent figures estimate the VA treats ~100,000 schizophrenia (Sz) patients each year, accounting for nearly 12% of VA healthcare costs. The PI’s ongoing clinical cognitive neuroscience research at the VA focuses on elucidating the neurobiology of suicidal behavior and Sz using neuroimaging and psychophysio- logical approaches. Suicide prevention and identification of promising new targets for intervention in Sz are critically important goals of the VA. The PI’s track record of federal funding and peer-reviewed publications in these two areas has helped advance the field and her VA-funded grants may identify biomarkers which aid in prospectively identifying Veterans at greatest risk for suicide. This RCS Award will allow the PI to continue and expand her highly collaborative VA research and mentoring of promising VA fellows and clinician-scientists.

PI_NAMEs: HAZLETT, ERIN A. (contact)

PROJECT_TERMS: acceptability and feasibility;Accounting;Acute;Admission activity;Affect;Animal Model;Area;Attenuated;Award;Behavioral;Biological Factors;biomarker identification;Blood;Brain;career;Caring;Clinical;Clinical Research;Cognitive;cognitive control;cognitive neuroscience;Cognitive remediation;Collaborations;Data;Decision Making;Diagnostic;Diffusion Magnetic Resonance Imaging;Disease;Doctor of Philosophy;editorial;Educational process of instructing;Epigenetic Process;Etiology;evidence base;Exhibits;Feasibility Studies;feasibility testing;Feeling suicidal;Functional Magnetic Resonance Imaging;functional outcomes;Funding;Genetic;Goals;Grant;Health Care Costs;high risk;Impairment;implementation intervention;improved;Impulsivity;Individual;Inflammation;Inpatients;Institutional Review Boards;International;Intervention;Journals;Leadership;longitudinal design;Longitudinal Studies;Magnetic Resonance Imaging;Major Depressive Disorder;Manuals;Medical center;medical schools;member;Mentors;mild traumatic brain injury;Motor;MRI Scans;multimodality;National Institute of Mental Health;Natural Language Processing;neural circuit;Neurobiology;Neurocognition;neuroimaging;Neuronal Plasticity;Neurosciences Research;New Jersey;next generation;novel;Oranges;Participant;Pathologic;Patients;Peer Review;Personality Disorders;Phenotype;Pilot Projects;Population;Positioning Attribute;Problem Solving;programs;prospective;Psychiatry;Psychological Factors;Psychology;Psychophysiology;Psychoses;Public Health;Publications;Publishing;Quality of life;Recording of previous events;Research;Research Project Grants;Review Committee;Risk;Risk Factors;Role;Sampling;Schizophrenia;schizophrenia spectrum disorder;Schizotypal Personality Disorder;Scientific Societies;Scientist;Services;Severities;Site;Societies;Study Section;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Symptoms;telehealth;Testing;Treatment Factor;United States;United States National Institutes of Health;Veterans;Work

PROJECT_TITLE: CSRD Research Career Scientist Award Application


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: Boston

ORG_DEPT: CHEMISTRY

ORG_NAME: TUFTS UNIVERSITY MEDFORD

ORG_STATE: MA

PHR: Project Narrative: A Continuous Flow-Based Approach to Automated Microbial Oligosaccharide Synthesis.  This research will result in an inexpensive and predictable approach for the automated construction of biologically important carbohydrates. This proposal is relevant to public health because it will provide a method for the rapid synthesis of carbohydrate libraries to aid in developing next-generation therapeutics and diagnostic tools. The chemistry developed through this proposal is relevant to the part of the NIH's mission that pertains to basic biomedical research.

PI_NAMEs: BENNETT, CLAY SAMUEL (contact);POHL, NICOLA L. B.

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acids;Acinetobacter baumannii;Address;Area;Automation;Biological Phenomena;Biology;Biomedical Research;Carbohydrates;Carbon;Catalysis;Chemicals;Chemistry;Complex;Computer software;Consumption;Coupling;Data;design;Detection;Development;diagnostic development;diagnostic tool;Ensure;Enzymes;ESKAPE pathogens;flexibility;Glycobiology;glycosylation;Goals;graphical user interface;Hour;Human;Human Microbiome;Individual;Infection;Intervention;Laboratories;Libraries;Methods;microbial;Mission;Modeling;Monitor;Monosaccharides;Nature;novel therapeutics;O Antigens;Oligosaccharides;open source;Organism;pathogen;pathogenic bacteria;pathogenic microbe;Phase;Play;Polysaccharides;Process;Production;programs;Public Health;Publishing;rapid technique;Raspberry Pi;Reaction;repository;Reproducibility;Research;Role;Route;Running;S phase;Solid;Structure;sugar;System;Technology;technology platform;therapeutic development;Time;tool;United States National Institutes of Health;Work

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Colorectal Cancer;Digestive Diseases;Rare Diseases;Urologic Diseases

ORG_CITY: EDINBURG

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

PHR: Project Narrative: Colorectal cancer (CRC) is the second deadliest cancer, and patients’ survival rate drops from 90% to 14% when cancer metastasize to the distant organs. Thus, herein, we proposed to investigate role of a long noncoding RNA (LncRNA) in anoikis resistance, and CRC metastasis. This study will provide new insights in CRC metastasis and will help in developing innovative therapeutics to improve patients’ survival, generate data for future NIH proposals and training of Hispanic underserved minority students at the University of Texas Rio Grande Valley (UTRGV), which is a major Hispanic serving institution in South Texas Rio Grande Valley region.

PI_NAMEs: TRIPATHI, MANISH K (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Adult;Anchorage-Independent Growth;Anoikis;anti-cancer research;Anti-sense RNA;Antibodies;Apoptotic;Biological Assay;bioluminescence imaging;Biotin;cancer cell;Cardiovascular system;Cell Cycle;Cell Line;Cells;Clinical;Code;Colon;colon cancer cell line;colon cancer metastasis;colon cancer patients;Colorectal Cancer;colorectal cancer metastasis;Consumption;crosslink;Data;Development;digital;Disease;Distant;Drops;Female;fighting;Freezing;Future;glucose metabolism;Glucose Transporter;glucose uptake;Goals;Hispanic;Hispanic-serving Institution;Human;Immunoprecipitation;improved;In Vitro;in vivo;innovation;insight;Investigation;knock-down;lentivirally transduced;Ligation;Link;link protein;Liver;Luciferases;Lymphatic System;male;Malignant Neoplasms;metastatic colorectal;Minority;minority student;Modeling;Molecular;Monitor;mouse model;Mus;Neoplasm Metastasis;novel;novel therapeutic intervention;Oncogenic;Organ;overexpression;Paraffin Embedding;Pathway interactions;Patients;Phosphorylation;Phosphotransferases;Portal vein structure;Precipitation;Process;programs;protein expression;Proteins;Proteome;Proteomics;Regulation;Research;Resistance;Reverse Transcriptase Polymerase Chain Reaction;RNA;Role;Signal Pathway;Site;Slide;South Texas;stemness;Students;sugar;Survival Rate;SW480;SW620;Testing;Texas;Therapeutic;Time;Tissue Embedding;Tissues;Training;transcriptome sequencing;Transitional Cell Carcinoma;Travel;trizol;underserved minority;United States National Institutes of Health;Universities;Untranslated RNA;Up-Regulation;Western Blotting

PROJECT_TITLE: Role of lncRNA UCA1 in anoikis resistantce and colorectal cancer metastasis


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: MILWAUKEE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative This project will explore how chronic opioid exposure desensitizes Mu opioid receptors and affects the output of the paraventricular nucleus of the thalamus (PVT), and how manipulating neuronal activity in this brain region might reduce aversive behavioral effects associated with opioid withdrawal.

PI_NAMEs: FRIEDMAN, VLADISLAV  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Action Potentials;Address;Adverse effects;Affect;Agitation;Animal Behavior;Anxiety;Arousal;Behavior;behavior test;Behavioral;behavioral phenotyping;Biological Assay;Brain region;CACNA1G gene;Canis familiaris;channel blockers;Chronic;Couples;Cre-LoxP;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;desensitization;Dorsal;Drug Addiction;drug craving;Eating;Electrophysiology (science);Enkephalins;Exhibits;experimental study;Fiber;G-Protein-Coupled Receptors;Genes;Genetic;Glutamates;Grooming;GTP-Binding Proteins;Hunger;Image;Immunohistochemistry;In Situ Hybridization;in vivo;Infusion procedures;Intervention;inward rectifier potassium channel;Ion Channel;Knock-out;Learning;Location;Mediating;Membrane;Messenger RNA;Microinjections;Morphine;mu opioid receptors;Mus;Naloxone;neuroadaptation;Neurons;Neurosciences;novel;Opioid;opioid abuse;Opioid agonist;opioid exposure;opioid mortality;opioid overdose;Opioid Receptor;opioid use;opioid withdrawal;Output;Pharmacology;Photometry;Public Health;real time monitoring;Receptor Activation;Regulation;Relapse;Research;Research Personnel;Rest;Rewards;Rodent;Role;Saline;Severities;Signal Transduction;Slice;Structure of paraventricular nucleus of thalamus;Symptoms;Techniques;Testing;Thalamic structure;Therapeutic;training opportunity;Tremor;United States;Up-Regulation;Viral;voltage;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Regulation of neuronal activity in the paraventricular thalamus by chronic morphine


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Isoniazid-resistant TB (INHr-TB) is the most common form of drug-resistant TB worldwide, and is a precursor to multidrug-resistant TB. INH resistance is rarely diagnosed leading to major gaps in our understanding of this disease. This project will provide critical insight into the epidemiology of INHr-TB including sentinel populations for the emergence of INHr-TB and congregate settings outside the household where INHr-TB is transmitted.

PI_NAMEs: WALSH, KATHLEEN F (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Adolescent;Adult;Affect;aged;Archives;Award;Biological Assay;Biometry;career;career development;Cessation of life;Church;Clinical;community setting;Contact Tracing;Contracts;Country;Data;Detection;Development Plans;Diagnosis;Diagnostic;Disease;Disease Clusterings;Drug resistance;Drug resistance in tuberculosis;Enrollment;Environment;Epidemiologist;Epidemiology;experience;genome sequencing;Genotype;Geographic Information Systems;Germany;Goals;Haiti;Haitian;high risk;Home;Household;improved;indexing;Infection;insight;Internal Medicine;Interview;Isoniazid resistance;Learning;Longitudinal Studies;Lung;Maps;Medicine;Mentorship;Molecular;Molecular Disease;Molecular Epidemiology;mortality risk;Multi-Drug Resistance;Multidrug-Resistant Tuberculosis;Mycobacterium tuberculosis;new epidemic;New York;Newly Diagnosed;Nurses;older adult;Paper;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Physicians;Population;Positioning Attribute;Predisposition;Prevalence;prevent;Prevention;Prevention program;Prevention strategy;Preventive;Preventive therapy;programs;prospective;Publications;Pulmonary Tuberculosis;Research;Research Support;Resistance development;Resources;Rifampin;Risk;Scientist;Sentinel;Single Nucleotide Polymorphism;skill acquisition;skills;spatial epidemiology;Testing;Time;Time trend;Training;transmission process;treatment center;Treatment Failure;trend;Tuberculosis;tuberculosis treatment;United States National Institutes of Health;whole genome;Work;Youth

PROJECT_TITLE: Sentinel populations and transmission hotspots of isoniazid-resistant tuberculosis

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

PHR: PROJECT NARRATIVE The central goal of this research program is to understand the molecular and cellular mechanisms that direct the assembly of of direction selective circuits in the mammalian visual system. These experiments will advance our understanding of visual system circuit development and function that are critical for mediating appropriate responses to image motion. This work may also aid in developing strategies for reestablishing functionally precise connectivity in the visual system following neuronal injury or degeneration.

PI_NAMEs: KOLODKIN, ALEX L (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Antigen-Presenting Cells;Cell Physiology;Cell surface;Cells;Cellular Morphology;Cellular Structures;Complex;Dendrites;Development;differential expression;Dorsal;Event;experimental study;ganglion cell;Generations;Genes;Goals;Image;Integral Membrane Protein;Location;Mediating;Molecular;Morphology;Motion;Mus;Nerve Degeneration;neural;neural circuit;neuron development;Neuronal Differentiation;Neuronal Injury;Neurons;object motion;Optics;Pattern;preference;Process;programs;Protein Secretion;Protein Tyrosine Phosphatase;receptor;Regulation;Research;response;Retina;Retinal Ganglion Cells;selective expression;Series;starburst amacrine cell;Synapses;synaptogenesis;System;Testing;Tissue-Specific Gene Expression;transcription factor;transcriptomic profiling;Visual System;Work

PROJECT_TITLE: Molecular mechanisms underlying direction-selective circuit assembly and function in the mouse visual system

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Inflammatory Bowel Disease;Microbiome;Precision Medicine;Skin Cancer

PHR: PROJECT NARRATIVE Our goal is to characterize intestinal biopsies, gut microbiome, and blood serum specimens from melanoma cancer patients developing colitis as a side effect of treatment with immune checkpoint blockade therapies, and to test whether immune, serologic, and gut microbiome signatures originally discovered in patients with inflammatory bowel disease could be useful predictors, help mitigate symptoms, and improve response to treatment.

PI_NAMEs: COLOMBEL, JEAN-FREDERIC ;FAITH, JEREMIAH JAMES;GNJATIC, SACHA  (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: 16S ribosomal RNA sequencing;anti-CTLA4;anti-PD-1;Antibodies;antimicrobial;Autoantibodies;bacterial community;Biological Assay;Biological Markers;Biological Products;Biopsy;Blood;cancer immunotherapy;Cancer Patient;Cells;Clinic;Clinical;clinical development;Clinical Trials Design;Colitis;Colorectal;Combination immunotherapy;Combined Modality Therapy;Crohn's disease;CTLA4 blockade;CTLA4 gene;cytokine;Data;density;Development;Disease remission;Dose;Enzyme-Linked Immunosorbent Assay;fecal transplantation;Feces;Flowers;frontier;Future;Genetic;Genomics;Gnotobiotic;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;gut microbiome;gut microbiota;Immune;immune checkpoint;immune checkpoint blockade;Immune Targeting;immune-related adverse events;Immunohistochemistry;Immunologic Markers;Immunological Models;Immunologist;Immunotherapy;improved;Inflammatory;Inflammatory Bowel Diseases;Intestines;ipilimumab;Knowledge;Lamina Propria;Learning;Lesion;Life;Malignant Neoplasms;Maps;Measures;Medical Oncologist;Melanoma;Melanoma patient;metagenomic sequencing;microbial;microbiome;microbiome analysis;microbiome composition;microbiome signature;Modeling;Monoclonal Antibodies;Nature;Nivolumab;novel;Patient risk;patient subsets;Patients;peripheral blood;Pharmaceutical Preparations;predictive marker;Predictive Value;Progression-Free Survivals;prospective;Proteins;Proteomics;Recommendation;response;Risk Factors;Safety;Scientist;serological marker;Serology;Serum;Serum Markers;single cell analysis;single-cell RNA sequencing;Specialist;Specimen;Steroids;Structure;Symptoms;targeted agent;Testing;Therapeutic;Tissues;TNF gene;transcriptomics;treatment response;Treatment Side Effects;tumor;tumor-immune system interactions;Ulcerative Colitis

PROJECT_TITLE: Characterizing and predicting colitis in immune checkpoint blockade-treated cancer patients


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative  This proposed research is to develop new statistical estimation and inference methods for deep learning with their applications to neuroimaging genetics for Alzheimer's disease (AD), which is expected to contribute to the elucidation of genetic components and etiology of AD with potential applications to other common diseases, thus facilitating their prevention, early diagnosis and therapeutic development.

PI_NAMEs: PAN, WEI  (contact);SHEN, XIAOTONG TOM

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Advocate;Affect;Alzheimer's Disease;Architecture;Atlases;biobank;Biological;Black Box;Brain;Classification;combinatorial;Communities;Complex;Computer software;convolutional neural network;cost;cost effective;Data;Data Analyses;deep learning;deep learning model;Development;Disease;Documentation;Early Diagnosis;endophenotype;Entropy;Environment;Etiology;feature extraction;feature selection;Genetic;genetic association;genetic variant;genome wide association study;genomic locus;Genotype;high dimensionality;High-dimensional Modeling;Image;improved;Individual;insight;interest;Investigation;Knowledge;Learning;Magnetic Resonance Imaging;Manuals;method development;Methodology;Methods;model building;Modeling;Modification;Nature;neural;neural network architecture;neuroimaging;Noise;novel;novel strategies;Outcome;Performance;Phenotype;predictive modeling;Prevention;Process;programs;Proxy;Psychological reinforcement;Public Domains;Publishing;Pythons;Relaxation;Research;software development;Speed;Statistical Computing;Statistical Methods;success;Testing;theories;therapeutic development;tool;trait;web site;Writing

PROJECT_TITLE: Deep Learning with Neuroimaging Genetic Data for Alzheimer's Disease


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Artificial heart/lung machines used to treat patients with severe lung and heart conditions can be lifesaving but can also result in potentially fatal blood clots and inflammation-driven organ damage. Evidence suggests that a blood protein called factor XII plays a major role in driving both blood clots and inflammation-driven organ damage in patients requiring heart/lung machines. This proposal seeks to define the potential of factor XII as a therapeutic target for patients needing heart/lung machines, identify additional targets, and understand how factor XII drives blood clot formation and organ damage in these settings.

PI_NAMEs: MORALES, DAVID L;PALUMBO, JOSEPH S. (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Animal Model;Animals;Anticoagulants;Anticoagulation;Antisense Oligonucleotides;Artificial Heart;Automobile Driving;Biological;Blood coagulation;Blood Proteins;Blood Vessels;Bradykinin;Cardiac;Cardiac Surgery procedures;Cardiopulmonary Bypass;Circulation;Clinical Trials;Combined Modality Therapy;Complement;Complement Activation;Complement component C6;Coupling;Critical Illness;Data;DNA;Endothelium;Event;experimental study;Exposure to;Extracorporeal Membrane Oxygenation;Factor Analysis;Factor IXa;Factor XI;Factor XIa;Factor XII;Factor XIIa;Fiber;Future;Gene Targeting;Generations;genetic approach;Heart;Heart and Lung machine;Hemorrhage;Hemostatic Agents;Heparin;High-Molecular-Weight Kininogen;In Vitro;Infection;Inflammation;Inflammation Mediators;Inflammatory;insight;interest;Kininogenase;Knowledge;Life;Link;Lung;macromolecule;mechanical circulatory support;Mechanics;Mediating;Membrane Oxygenators;Modeling;Morbidity - disease rate;mortality;Myocardial;Myocardium;Natural Immunity;new therapeutic target;novel;operation;Operative Surgical Procedures;Organ;organ injury;particle;Pathology;Pathway interactions;Patients;Peptide Hydrolases;pharmacologic;Play;Polyphosphates;Prekallikrein;Rattus;respiratory;Risk;Role;Sepsis;Sternotomy;Surgical Hemostasis;System;systemic inflammatory response;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic target;Thrombin;Thromboembolism;thromboinflammation;Thromboplastin;Thrombosis;thrombotic;thrombotic complications;tool;Translating

PROJECT_TITLE: The role of contact pathway factors in mechanical circulation

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Public Health Statement The mammalian transcriptome regulates numerous critical cell functions, and the ability to con- trol the transcriptome will lead to breakthrough cellular therapies for many diseases. We pro- posed to develop tools that can enhance the sensitivity and specificity of transcriptome engi- neering and demonstrate their clinical potential by improving the safety of cell therapy. Success from this work will greatly enhance our ability to design novel therapeutic and diagnostic appli- cations.

PI_NAMEs: WONG, WILSON  (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Antitumor Response;Biological;CAR T cell therapy;Cell Physiology;Cell Therapy;Cells;Chemicals;chimeric antigen receptor;chimeric antigen receptor T cells;Chromatin Structure;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;combat;Cues;cytokine;cytokine release syndrome;Dangerousness;design;Dimerization;Disease;Engineering;extracellular;FDA approved;flexibility;Gene Expression;Genes;Genetic;Genetic Engineering;genome editing;Genome engineering;Guide RNA;Human;Immune;improved;In Vitro;interest;Investigation;Knock-out;Lead;Light;Malignant Neoplasms;Mammalian Cell;Modeling;Mus;novel;novel diagnostics;novel therapeutics;Orthologous Gene;Pharmaceutical Preparations;prevent;Production;programs;Public Health;Publishing;response;Ribonucleases;RNA Degradation;RNA Interference;Safety;Sensitivity and Specificity;sensor;side effect;Signal Pathway;Signal Transduction;Site;small molecule;Specificity;success;Surface Antigens;therapy development;tool;transcription factor;transcriptome;tumor;Work;Xenograft procedure

PROJECT_TITLE: Multiplexed and Logical Control of the Mammalian Transcriptome Using Cas13

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Liver Disease;Regenerative Medicine

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE Inflammation is a protective process that must be terminated in a timely manner by the processes of resolution to achieve organ system health. We have identified a new mechanism by which the lipid mediator sphingosine 1-phosphate (S1P) acts on neutrophil S1P receptor-1 to induce resolution processes and achieve organ health after viral and chemical insults. This proposal will help clarify this poorly understood mechanism and develop new therapeutic approaches to control tissue damage of various organ systems.

PI_NAMEs: HLA, TIMOTHY TUN (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Acetaminophen;Acute Liver Failure;Agonist;antagonist;Anti-Inflammatory Agents;Atherosclerosis;Attenuated;attenuation;Autoimmune Diseases;beta-arrestin;Biological;Blood Vessels;Body System;Cells;Chemicals;Chromatin;Chronic;chronic inflammatory disease;Complex;Coupled;CXCR4 gene;Cytoplasmic Granules;Data;desensitization;Development;Disease;Eicosanoids;Engineering;Epithelium;Event;Exhibits;extracellular;FDA approved;Fibrosis;Foundations;FPR2 gene;Functional disorder;G protein coupled receptor kinase;G-Protein-Coupled Receptors;Gene Expression;Genetic;Genetic Models;Genetic Transcription;Goals;GTP-Binding Proteins;Health;Health system;Hematopoietic;Hepatocyte;High Density Lipoproteins;Homeostasis;Homing;Immune;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Injury;Innate Immune System;innovation;Knowledge;Laboratories;lipid mediator;Liver;liver injury;LTB4R gene;Lung;lung injury;lung regeneration;Lysophospholipids;Macrophage;Mediating;Medicine;Methods;Molecular;Molecular Chaperones;mouse genetics;mouse model;Myelogenous;Myeloid Cells;Natural regeneration;neutrophil;Neutrophil Activation;novel;novel strategies;novel therapeutic intervention;Nuclear;Organ;oxidant stress;particle;Pathology;Pathway interactions;Phagocytosis;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Physiology;Play;Process;programs;Prostaglandins;receptor;Recovery;regenerative;Regenerative response;Regulation;repaired;Research;Resolution;response;Role;Seminal;Signal Induction;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;small molecule;Sphingolipids;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;synergism;targeted treatment;Testing;Therapeutic;tissue injury;tissue regeneration;Tissues;trafficking;transcriptome;Transgenic Mice;Vascular Endothelium;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: Myeloid sphingolipid regulation of tissue resolution and regeneration responses

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE: HIV exposure influences metabolomic pathways important to the development of cardiometabolic disease starting in early life. HEU children are at high risk for comorbid infections in early life, which may lead to systemic inflammation and contribute to cardiometabolic risk in early adolescence. Using novel metabolomic data, this study seeks to understand the impact of HIV exposure, early life infections and inflammatory response, on cardiometabolic outcomes in early adolescence in order to inform future screening and intervention strategies to improve cardiometabolic health among HEU and HU children.

PI_NAMEs: BENGTSON, ANGELA ;PELLOWSKI, JENNIFER ANN (contact);ZAR, HEATHER JOY

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: 10 year old;acylcarnitine;Address;Adolescence;Affect;Amino Acids;arterial stiffness;Bioinformatics;Biological;Biological Markers;biological sex;Biological Specimen Banks;biomarker identification;Birth;Blood Pressure;Branched-Chain Amino Acids;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular system;Child;Child Health;Childhood;Cholesterol;Climacteric;clinical application;Clinical Data;clinically relevant;cohort;Communicable Diseases;comorbidity;Data;Development;diabetogenic;Disease;disorder risk;Dyslipidemias;early adolescence;Early identification;Evaluation;experience;Exposure to;Fatty Acids;Functional disorder;Future;Health;high body mass index;high risk;HIV;Immune;improved;infancy;Infection;infection burden;infection risk;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Infrastructure;Insulin Resistance;Intervention;late life;LDL Cholesterol Lipoproteins;Life;Mediating;Mediation;Metabolic;Metabolic dysfunction;Metabolic Pathway;metabolic profile;metabolome;metabolomics;microbiome;modifiable risk;Molecular;Morbidity - disease rate;mortality;novel;Obesity;Outcome;Participant;Pathogenesis;Pathway interactions;Pediatric epidemiology;peri-urban;Perinatal Epidemiology;Plasma;population based;Positioning Attribute;predictive modeling;prospective;Puberty;Risk;Risk Factors;risk stratification;Sampling;screening;Severities;South Africa;South African;systemic inflammatory response;Time;Triglycerides;urban area;Work

PROJECT_TITLE: Early life determinants of cardiometabolic health from birth to adolescence amongst HIV-exposed and unexposed South African children

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ORG_CITY: CONCORD

ORG_NAME: STATE OF NEW HAMPSHIRE-DEPARTMENT OF AGRICULTURE, MARKETS & FOOD

ORG_STATE: NH

PHR: NH PATH C PAR-21-174  PROJECT NARRATIVE The New Hampshire Department of Agriculture, Markets and Food (DAMF) project titled: Continued Development of the NHDAMF Produce Safety Program under Path C for the Implementation of the FDA Produce Safety Rule is intended to support and build upon the current Produce Safety Program (PSP) in the state of New Hampshire. The DAMF PSP Mission is to: Ensure the safe production of quality produce; assure producer competitiveness in the marketplace; and establish a unified partnership with FDA to achieve an integrated food safety system. DAMF will utilize federal funding to support this project and facilitate the success of achieving the mission goals. Through continued program development, education and training, along with enforcement and compliance, we anticipate that NH’s stakeholders will have the tools to safely produce, harvest, pack or hold fresh produce, which in turn, will build public confidence in the safety of NH’s food systems.

PI_NAMEs: JASPER, SHAWN  (contact)

PROGRAM_OFFICER_NAME: FREDRICK, JEANETTE

PROJECT_TITLE: Path C Continued Development of the NHDAMF Produce Safety Program Under Path C for  Implementation of the FSMA Produce Safety Rule


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Physical Rehabilitation;Prevention;Rehabilitation;Telehealth

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Comprehensive cardiac rehabilitation (CR) programs have repeatedly demonstrated efficacy in reducing morbidity and mortality while improving symptoms and quality of life for patients living with CVD; unfortunately, enrollment, adherence, and completion of CR programs are particularly low and thus patients are not receiving these known benefits. We aim to determine the effectiveness of delivering patient-centered individualized CR programming through a mobile health (mHealth) remote case management system in an effort to a) increase participation in and adherence to CR programming, b) improve known modifiable CVD risk factors, and c) improve near- and mid-term patient-centered outcomes including re-hospitalizations and mortality. Ultimately, this type of enhanced clinical service will provide patients with additional/alternative strategies to engage with clinical care teams and improve healthcare outcomes.

PI_NAMEs: OLSON, THOMAS PATRICK (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Activities of Daily Living;Acute Coronary Event;acute coronary syndrome;Adherence;American;Behavioral;Blood Pressure;Cardiac;Cardiac rehabilitation;Cardiovascular Diseases;cardiovascular disorder risk;care outcomes;Case Management;Cause of Death;Cessation of life;Cholesterol;Chronic;Chronic Disease;Clinical;clinical care;Clinical Practice Guideline;Clinical Services;Consumption;Coronary Arteriosclerosis;coronary event;cost effectiveness;Data;Dedications;design;Developed Countries;Economic Burden;Educational Materials;Effectiveness;effectiveness evaluation;efficacy evaluation;Eligibility Determination;Enrollment;Equation;Event;experience;falls;Goals;Health;health care economics;Healthcare;Heart failure;hospital readmission;improved;Individual;Intervention;Measures;mHealth;Morbidity - disease rate;mortality;Myocardial Infarction;Outcome;participant enrollment;Patient Care;patient oriented;Patient Participation;Patient-Focused Outcomes;Patients;percutaneous coronary intervention;Performance;Pharmaceutical Preparations;Physicians;primary outcome;Procedures;programs;prospective;Quality of life;Randomized, Controlled Trials;Recommendation;Recurrence;Rehabilitation Outcome;rehabilitation service;Research;Risk Factors;Scientist;secondary outcome;Survivors;symptomatic improvement;System;Testing;United States;Well in self

PROJECT_TITLE: Improving Cardiac Rehabilitation outcomes through mobile case management (iCARE)

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Health Services;Mental Health;Mental Illness;Prevention;Primary Health Care;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Suicide is a leading cause of mortality, and suicide deaths have increased substantially in the US over the past two decades. Loneliness is a prevalent risk factor for suicide that has worsened following the COVID-19 pandemic, yet there is a paucity of effective primary care interventions to address loneliness. This study will develop and pilot test two primary care interventions, each utilizing complementary mechanisms, to improve loneliness and reduce suicidal ideation within a model of collaborative care to enhance intervention effectiveness and implementation.

PI_NAMEs: PFEIFFER, PAUL NELSON (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Academy;Acceleration;acceptability and feasibility;Address;Adopted;Adult;Anxiety;Anxiety Disorders;arm;Behavior Therapy;behavioral health;Caring;Case Manager;Cause of Death;Chronic;Clinic;Clinical;Cognitive;Cognitive Therapy;Collaborations;collaborative care;Communities;community organizations;comorbid depression;Complementary therapies;COVID-19 pandemic;design;Development;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness trial;Eligibility Determination;Engineering;Enrollment;Epidemic;Exercise;expectation;experience;Feeling suicidal;follow up assessment;Frequencies;Future;health care settings;health related quality of life;Health Services;Health system;Hybrids;Impairment;implementation/effectiveness;improved;innovation;Intervention;Investigational Therapies;Lead;Link;Loneliness;lonely individuals;Managed Care;Managed Care Programs;Manuals;Measures;Medicare;Medicine;Mental Depression;Mental Health;Meta-Analysis;Modeling;mortality;Outcome;Participant;patient engagement;patient response;Patients;Pharmacotherapy;Pilot Projects;pilot test;Prevalence;Primary Care;primary care clinic;primary care practice;primary care provider;primary outcome;Production;Protocols documentation;Provider;Psychiatry;Public Health;Randomized;Recovery;reducing suicide;Research;Risk Factors;Role;Science;secondary outcome;Services;Site;social;social engagement;social health determinants;Social Interaction;Social isolation;structural determinants;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;Surgeon;Testing;Therapeutic Intervention;three-arm trial;Time;tool;Training;treatment arm;treatment as usual;volunteer

PROJECT_TITLE: Development and Pilot Study of Primary Care Loneliness Interventions to Prevent Suicide


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Neurosciences

ORG_CITY: EAST LANSING

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE (RELEVANCE) The manifestation of gastrointestinal (GI) motility and functional bowel disorders is caused, in part, by alterations to the function or survival of neurons that control GI muscle. The proposed studies investigate how glial cells that surround these neurons regulate their function and how altered glial regulation contributes to dysmotility. A detailed understanding of the role of enteric glia will lead to new therapies to treat GI motility and functional bowel disorders.

PI_NAMEs: GULBRANSEN, BRIAN D. (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Acute;Address;Affect;Biological Assay;calcium indicator;Cells;Chronic;Colitis;Complex;Cues;Data;Development;Disease;Enteral;Enteric Nervous System;excitatory neuron;experimental study;Feedback;Functional disorder;Funding;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal Motility;Genetic;glial activation;Glial Fibrillary Acidic Protein;Goals;Health;Human;Image;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inhibitory neuron;insight;Intestinal Motility;Intestinal Pseudo-Obstruction;Intestines;Irritable Bowel Syndrome;Knockout Mice;Mediator;Modeling;Motility;motility disorder;Motor;motor behavior;Motor Pathways;mouse model;Mus;Muscle;Mutant Strains Mice;neural circuit;neural network;Neural Pathways;Neuroglia;neuroinflammation;neuron loss;neuronal excitability;Neuronal Plasticity;neuronal survival;Neurons;neuroregulation;neurotransmission;Neurotransmitters;Nitrergic Neurons;novel;novel strategies;novel therapeutics;Peristalsis;Pharmaceutical Preparations;Phase;recruit;Recruitment Activity;Reflex action;Regulation;Role;Signal Transduction;Specificity;Synapses;System;Testing;therapeutic development;Tissues;Transgenic Mice

PROJECT_TITLE: Regulation of enteric motor neurocircuits by enteric glia in health and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


NIH_SPENDING_CATS: Hematology;Pediatric

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Women and minorities are underrepresented among the leadership in pediatrics and pediatric subspecialties, including nonmalignant hematology. In this R25 application, we propose to develop a program focused on hematology to recruit recent underrepresented high school graduates and community college students to receive hands-on laboratory experience with experienced faculty mentors, introduction to the field of hematology, career development workshops, scientific presentation and writing skills. This program will help to fill the pipeline to develop future underrepresented researchers in hematology.

PI_NAMEs: HALPERN-FELSHER, BONNIE L;SAKAMOTO, KATHLEEN M (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Address;Advisory Committees;Area;career development;Childhood;Cities;Clinical;Committee Members;Communities;community college;Country;Data;disability;disadvantaged background;Discipline;Disease;Disparity population;Distress;Education Projects;Educational Curriculum;Educational process of instructing;Educational workshop;Eligibility Determination;Ethics;ethnic diversity;Ethnic Population;experience;Exposure to;Faculty;faculty mentor;Feedback;Funding;Future;Goals;graduate school;Grant;Hematology;high school;improved;improved outcome;Individual;Infrastructure;innovation;Institution;interest;Laboratories;laboratory experience;Leadership;lectures;Medical center;Medical Residency;medical schools;Medicine;meetings;Mentors;Mentorship;Mission;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Non-Malignant;Participant;Pediatric Hematology;Pediatrics;Persons;Physicians;Population;Positioning Attribute;Postdoctoral Fellow;posters;Preparation;programs;racial population;recruit;Reduce health disparities;Reporting;Research;Research Personnel;Research Technics;Rotation;Scientist;Sickle Cell Anemia;skills;stem cell biology;student mentoring;student training;Students;summer program;summer research;symposium;Techniques;Thalassemia;Training;Training Programs;trend;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States;United States National Institutes of Health;Universities;university student;Vocational Guidance;Wages;Woman;working group;Writing

PROJECT_TITLE: Increasing Diversity in Hematology: Training for Underrepresented Students

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Transplantation of therapeutic cells to replace damaged tissues holds great potential in treating or providing relief to various illness, such as type 1 and advanced type 2 diabetes, kidney failure and heart disease. At present, cell transplantation is hindered by short-term survival and function of implanted cells and rejection by the patient’s immune system. We propose to develop an adjuvant system using extracellular vesicles (EVs) derived from mesenchymal stem cells to address these impediments in cell transplantation while enabling monitoring of EVs using magnetic particle imaging for adjustment and customization of the adjuvant treatment as needed by individual patients.

PI_NAMEs: ARIFIN, DIAN RESPATI (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Address;Adjuvant;Adjuvant Therapy;Adopted;Alginates;bench to bedside;Beta Cell;Biodistribution;bioluminescence imaging;Blood;capsule;Cations;Cell Therapy;Cell Transplantation;cell type;Cells;Clinic;Clinical;clinical translation;clinically relevant;Cosmetics;cost;design;detection sensitivity;Dose;Drug Delivery Systems;Drug Kinetics;Encapsulated;Engineering;Engraftment;Ensure;Excipients;exenatide;extracellular vesicles;Fatty acid glycerol esters;FDA approved;ferumoxtran;ferumoxytol;follow-up;Food;GLP-I receptor;Heart Diseases;Hot Spot;Hour;Human;Hydrogels;Image;imaging detection;Immune system;immunodeficiency;immunogenicity;Implant;implantation;improved;In Vitro;in vivo;individual patient;Inflammation;Injectable;Injections;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;interest;intraperitoneal;iron oxide nanoparticle;islet;Islets of Langerhans;Islets of Langerhans Transplantation;Japan;Kidney Failure;Kinetics;Label;Life;Ligands;Liposomes;Liver;Logistics;Luciferases;Magnetic Resonance Imaging;Magnetism;Medicine;Mesenchymal Stem Cells;meter;Methods;Microcapsules drug delivery system;Modality;Molecular Weight;Monitor;Morphologic artifacts;Motion;Mus;Non-Insulin-Dependent Diabetes Mellitus;Outcome;particle;Pathologic;Patients;Performance;Pharmacologic Substance;Physicians;Portal vein structure;Positron-Emission Tomography;post-transplant;preservation;Production;Property;Protocols documentation;Radioactive;Reporting;Route;scaffold;single photon emission computed tomography;Site;Spatial Behavior;Surface;System;Techniques;Testing;theranostics;Therapeutic;therapy outcome;Tissues;tool;Tracer;Translations;Transplantation;uptake;Vesicle;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: Theranostic system for targeted, sustained-delivery with quantitative "hot spot" MPI of magnetic extracellular vesicles

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-M(82)S]


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Heart Disease;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative As current resuscitation methods only provide 25-30% of cardiac output and are limited by the inability of clinicians to deliver CPR effectively up to 50% of the time, developing methods to improve cardiopulmonary resuscitation (CPR) is essential to enhance patient survival and reduce brain injuries after cardiac arrest (CA). A promising method to enhance CPR is through a physiological feedback system incorporating measures related to brain oxygen delivery and circulation quality. This grant aims to a) identify the optimal physiological resuscitation target using regional cerebral oxygenation (rSO2) or end tidal carbon dioxide (ETCO2) or combination; b) explore the mechanisms by which the optimal physiological resuscitation target leads to improved survival and neurological outcomes; c) conduct a pilot trial to compare the impact of real-time physiological feedback CPR vs. non-physiological feedback CPR on the ability to restart the heart and achieve improved survival and neurological outcomes.

PI_NAMEs: PARNIA, SAM  (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Address;American Heart Association;Anoxia;Anoxic Encephalopathy;attenuation;Awareness;Biological Markers;Blood specimen;Brain;Brain Injuries;Carbon Dioxide;Cardiac Output;Cardiopulmonary Resuscitation;Caring;Categories;cerebral oxygenation;Cerebrum;Cessation of life;Circulation;Clinical Trials;Conscious;cost;Data;diagnostic accuracy;Dose;Encephalitis;Enzyme-Linked Immunosorbent Assay;Event;Exhibits;Feedback;functional status;Goals;Grant;Health;Heart;Heart Arrest;Hospitals;Hour;Impairment;improved;Incidence;Inflammation;Inflammatory;Injury;Ischemia;Measures;Meta-Analysis;Methods;Monitor;Morbidity - disease rate;mortality;Near-Infrared Spectroscopy;Nervous System Physiology;Nervous System Trauma;Neurologic;Neurological outcome;Neurological status;novel;Observational Study;Organ;Outcome;Outcome Measure;outcome prediction;Oxygen;Patients;Performance;Perfusion;Physiological;pilot trial;primary outcome;Process;prospective;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reperfusion Injury;Reperfusion Therapy;response;Resuscitation;secondary outcome;Serum;Site;survival outcome;Survival Rate;System;Testing;Time;Tissues

PROJECT_TITLE: Goal directed cardiopulmonary resuscitation in cardiac arrest using a novel physiological target: A pilot mechanistic randomized control trial

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: LAS CRUCES

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: PROJECT NARRATIVE The Animal Feed Regulatory Program Standards (AFRPS) establishes a uniform foundation for the regulation of animal feed that establishes the safety and integrity of the U.S. animal feed supply and ensures a uniform and consistent approach to feed regulation among states. While many states may not have sufficient resources on their own, participation in and funding provided by this grant opportunity provides the resources to implement and maintain a viable, aligned feed regulatory program contributing to a nationally integrated feed safety system.

PI_NAMEs: LANEY, KATIE  (contact)

PROGRAM_OFFICER_NAME: BHATTACHARYYA, SOMA

PROJECT_TITLE: New Mexico Department of Agriculture Maintenance of the Animal Feed Regulatory Program Standards


ORG_CITY: TRENTON

ORG_NAME: NEW JERSEY STATE DEPARTMENTR/AGRICULTURE

ORG_STATE: NJ

PHR: NJDA AFRPS Maintenance Phase – Project Narrative This project will help to directly reduce public health risks by sampling for pathogens in animal feed and pet food, which are handled by commercial agricultural workers, as well as homeowners. It will also reduce indirect risk causing illness in animals, which are subsequently consumed, handled or otherwise come in contact with humans.

PI_NAMEs: KELLER, JOHN A (contact)

PROGRAM_OFFICER_NAME: LOWE, SHANNON

PROJECT_TITLE: NJDA AFRPS Maintenance Grant


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Chicago

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The long-term efficacy of adeno-associated virus (AAV) based therapies have been limited in their utility to treat chronic neurological diseases. This is increasingly important as more investigators plan to use AAV to treat various disorders in addition to some therapy protocols finishing clinical trials and receiving FDA approval for patient use. Identifying possible problems with long term efficacy of AAV therapy, as well as alternative approaches to avoid those problems are vital and significant aspects of gene therapy and key for the overall mission of NIH.

PI_NAMEs: HELLER, GREGORY J (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: 3 year old;adeno-associated viral vector;adeno-associated virus 9 delivery;adenovirus mediated delivery;Adult;Affect;Aftercare;Age;aged;Animals;Architecture;Behavioral;Biochemical;Birth;Brain;burden of illness;Capsid Proteins;Catabolism;Cell membrane;cell type;Cells;Cessation of life;Characteristics;chronic neurologic disease;Clinical;Clinical Trials;clinically relevant;Complementary DNA;Data;Demyelinations;Dependovirus;design;Deterioration;Development;Developmental Delay Disorders;Diffuse;Disease;Disease Progression;DNA;dosage;Dose;Effectiveness;Elderly;end of life;Enzymes;Episome;exhaustion;experimental study;Failure to Thrive;Fluorescent in Situ Hybridization;functional restoration;galactosylceramidase;gene therapy;Genes;Globoid cell leukodystrophy;Goals;Hematopoietic Stem Cell Transplantation;Histologic;Histopathology;Immunohistochemistry;immunoreaction;Impairment;improved;Infant;Inherited;Intrathecal Injections;intravenous injection;Investigation;Lesion;leukodystrophy;Life;Life Expectancy;Longevity;Measures;Mendelian disorder;Mission;Modality;Modification;mouse model;Mus;Mutation;Neonatal;Nerve Degeneration;Neurons;neuropathology;oligodendrocyte progenitor;Oligodendroglia;Paralysed;Pathologic;Patients;postnatal;preclinical trial;prevent;Protocols documentation;Psychosine;Quality of life;Recurrent disease;Research Personnel;Signal Pathway;stem cells;success;Teenagers;Testing;Therapeutic;Time;Tissues;treatment duration;Treatment Efficacy;Treatment Protocols;United States National Institutes of Health;vector;viral DNA;Viral Genome;white matter;Wild Type Mouse

PROJECT_TITLE: Improving AAV-based gene therapy for Krabbe Disease


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Arthritis;Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: NARRATIVE  Medicare’s Comprehensive Care for Joint Replacement (CJR) model was redesigned in 2021 to include adjustments for social and clinical risk – measures that could potentially reduce racial/ethnic and socioeconomic disparities in total joint replacement (TJR) care. We will investigate the redesigned CJR’s (rCJR) association with disparities in TJR access, outcomes, and spending, with a focus on the performance of safety-net hospitals. Our work is critical for understanding whether and how the rCJR can be leveraged to reduce TJR disparities nationally, and for realizing the elusive target of equity in TJR care for patients with arthritis.

PI_NAMEs: THIRUKUMARAN, CAROLINE PINTO (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Acute;Adverse event;Age;Area;Arthritis;beneficiary;Black race;bundled payment;Caring;Categories;Clinical;clinical risk;comorbidity;Comprehensive Health Care;Data;design;Disparity;disparity reduction;dual eligible;Eligibility Determination;Emergency department visit;Enrollment;Equity;ethnic disparity;ethnic minority;Funding;Goals;Health;hip replacement arthroplasty;Hispanic;hospital care;hospital readmission;Hospitals;improved;Incentives;Inpatients;Institution;Intervention;knee replacement arthroplasty;low socioeconomic status;marginalization;Measures;Medicare;Medicare/Medicaid;Methods;Modeling;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;Operative Surgical Procedures;Outcome;Outpatients;Pain;Patient Care;Patients;payment;Performance;Policy Analysis;Postoperative Period;Prevalence;Price;racial disparity;racial minority;Relaxation;Replacement Arthroplasty;Research;response;Rewards;Risk;Risk Adjustment;safety net;Social Adjustment;social disparities;social factors;socioeconomic disparity;socioeconomics;surgery outcome;theories;Total Hip Replacement;Vision;Work

PROJECT_TITLE: Association of the redesigned Comprehensive Care for Joint Replacement model with racial/ethnic and socioeconomic disparities in joint replacement surgeries

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: LOS ANGELES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Defects of the skull occur in trauma, stroke, cancer, and congenital anomalies resulting in significant neurological, psychological, social, and vocational burdens. The significant limitations of clinically available materials for calvarial reconstruction have demonstrated a need for targeted regenerative therapies. This proposal is focused on the development of a surgically practical, off-the-shelf, biomaterials-based solution for calvarial regeneration.

PI_NAMEs: LEE, JUSTINE CHIA (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Affect;Autologous;Biocompatible Materials;Biological;Biomechanics;bone;bone healing;Bone Regeneration;Bone Transplantation;Calvaria;Cell Communication;Cells;Cephalic;Clinical;clinical material;clinical translation;Collagen;congenital anomaly;Consumption;cost;cranium;cranium plastic repair;Data;Defect;Development;experimental study;Extracellular Matrix;fabrication;Glycosaminoglycans;Goals;Growth Factor;Human;improved;In Vitro;in vivo;Infection;Inflammation;inhibitor;Knowledge;Malignant Neoplasms;Mediator;Methods;mineralization;Morbidity - disease rate;nanocomposite;nanoparticulate;Natural regeneration;Neurologic;Operative Surgical Procedures;Oryctolagus cuniculus;osteoclastogenesis;Osteoclasts;Osteogenesis;osteogenic;osteoprogenitor cell;paracrine;Performance;pre-clinical;preclinical efficacy;Property;psychologic;reconstruction;regenerative;regenerative approach;regenerative therapy;Research;Safety;scaffold;Secondary to;Site;Skeleton;social;stem cell expansion;stem cells;Stroke;Supplementation;System;technology development;Time;Tissues;Trauma;Tumor necrosis factor receptor 11b;Vascularization;Vocation

PROJECT_TITLE: Osteoclast modulatory biomaterials for skull regeneration


PHR: Narrative Under a multi-PI leadership with a strong track record of scientific and mentorship collaboration, we propose a comprehensive regional interdisciplinary graduate and postgraduate training program (Kidney, Urologic, and Hematologic-Advanced Research Training or KUH-ART) to prepare trainees for long-term productive careers in advanced research in benign nephrology, urology and hematology. The overarching goal of the program is to recruit outstanding KUH trainees from diverse backgrounds and prepare them to lead multidisciplinary teams that produce KUH research with high impact on medical science and clinical outcomes. We benefit from exceptional resources: 1) our location one of the most creative and diverse metropolitan areas in the world, 2) UCLA, the top public University and its affiliates, and 3) relationships to elite research institutions including Caltech and RAND.

PI_NAMEs: FREEDLAND, STEPHEN JAY;GANZ, TOMAS ;SALUSKY, ISIDRO B. (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Academia;Adult;Advocacy;Ally;Area;Basic Science;Benign;Biomedical Engineering;Biotechnology;California;career;Cellular biology;Childhood;Clinical;Clinical Sciences;Collaborations;Communication;Communities;Computational Biology;Creativeness;Development;Developmental Biology;Doctor of Philosophy;doctoral student;E-learning;education research;educational atmosphere;Educational Curriculum;Educational Status;Endocrinology;Engineering;Epidemiology;Evaluation;Exposure to;Fellowship;Funding;Future;Geography;Goals;graduate student;Grant;Health;Health Services Research;Hematology;high school;improved;Incentives;Infrastructure;innovation;Institution;Instruction;inter-institutional;interest;iron metabolism;Iron Metabolism Disorders;Kidney;Kidney Diseases;Kidney Transplantation;Lead;Leadership;lectures;Location;Los Angeles;male;Manuscripts;Master of Science;Measures;Medical;Medical center;medical schools;medical specialties;Medicine;Mentors;Mentorship;metropolitan;minority health;multidisciplinary;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Outcome;outreach program;patient population;Pediatric Hematology;Pharmacology;Physicians;Physiology;Postdoctoral Fellow;pre-doctoral;Preparation;Process;Productivity;Professional Competence;Program Effectiveness;programs;Public Health;Recording of previous events;recruit;Research;Research Personnel;Research Training;Resources;Scholars Program;Science;Scientist;Series;Social Sciences;Students;Supervision;symposium;Talents;Technology;Traineeship;Training;Training Programs;Translational Research;United States National Institutes of Health;Universities;urologic;Urology;Vocational Guidance

PROJECT_TITLE: KUH-ART: Advanced Research Training in Kidney disease, Urology and Hematology


NIH_SPENDING_CATS: Hematology;Kidney Disease;Pediatric

PI_NAMEs: SALUSKY, ISIDRO B. (contact)

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Clinical Research;Eczema / Atopic Dermatitis

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Atopic dermatitis is the most common childhood chronic illness and is often a lifelong disease posting a major public health burden. The role of IgE antibodies has been controversial in atopic dermatitis, but our combined studies demonstrate for the first time that IgE is a key factor in acute itch associated with atopic dermatitis and that certain sugar molecules cause IgE to be more like enhance IgE potency. This project seeks to elucidate the role of IgE glycosylation as a trigger for itch and supports the NIH mission by providing a foundation for novel biomarkers and therapeutics in the management of itch.

PI_NAMEs: CONROY, MICHELLE E (contact);KIM, BRIAN

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Acute;Address;Affect;Affinity;Allergens;Allergic;Allergic Contact Dermatitis;Allergic inflammation;Antibodies;Asthma;Atopic Dermatitis;Basophils;Binding;Bullous Pemphigoid;Cell Degranulation;Cell surface;Childhood;Chronic;Chronic Disease;crosslink;Development;Disease;Disease remission;effective therapy;environmental allergen;Flare;Food Hypersensitivity;Foundations;Glycobiology;glycosylation;Goals;Histamine;Human;human model;IgE;Immunology;in vivo;Inflammation;innovation;Knowledge;Leukotriene C4;Leukotrienes;mast cell;Mediating;Mediator;Mission;mouse model;Mus;novel marker;novel therapeutics;Pathogenesis;Pathogenicity;Pathology;Patients;Pattern;Process;Production;Pruritus;Public Health;pyroglyphid;receptor;Regulation;Relapse;response;Role;Sampling;Severities;Sialic Acids;sialylation;Skin;sugar;Testing;Time;United States National Institutes of Health;Urticaria;Variant;Work

PROJECT_TITLE: Regulation of IgE and Atopic Itch

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Hematology;Kidney Disease

PI_NAMEs: NICHOLAS, SUSANNE B (contact)

PROJECT_TERMS: Association of American Medical Colleges;Basic Science;biomedical scientist;career;Career Choice;Communities;design;Development;Development Plans;Doctor of Philosophy;Education;Educational Curriculum;Ensure;ethnic minority;Evaluation;Exercise;experience;Faculty;Feedback;Fostering;Gender;Goals;Health;health management;Hematology;Human;Individual;Inequity;Infrastructure;Institution;Kidney;Kidney Diseases;Knowledge;Knowledge acquisition;Leadership;Link;male;Medical;member;Mentors;Mentorship;Mission;Modeling;Monitor;novel;Outcome;Participant;programs;racial minority;recruit;Research;Research Personnel;Research Training;Resources;Schools;Science;Scientific Advances and Accomplishments;Scientist;skills;success;Time;TNFSF15 gene;Training Programs;trend;Uncertainty;Urology;women faculty

PROJECT_TITLE: Development Core


NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Stroke;Traumatic Head and Spine Injury

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Millions of stroke survivors have difficulty walking due to weakness on one side of the body; many individuals adopt sedentary lifestyles, worsening their health and quality of life. In the short-term this study will determine preliminary efficacy of a device for significantly improving mobility and independence after stroke while defining techniques for implementation. Long-term, this should result in a clinical intervention that substantially improves walking speed, reduces fall risk, increases activity levels and overall health, and facilitates community access and independence.

PI_NAMEs: MAKOWSKI, NATHANIEL STEVEN (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Activities of Daily Living;Address;Adopted;Ankle;Bypass;cardiovascular health;Case Series;Case Study;Cervical;Clinical;clinical implementation;Clinical Trials;Cognitive;Communities;community setting;Compensation;Contracts;Data;design;Development;Devices;Effectiveness;Electric Stimulation;empowerment;Environment;exoskeleton;fall risk;falls;Fiber;follow-up;foot;functional improvement;functional independence;Future;Gait;Goals;hand dysfunction;Health;Hip region structure;Home;Impairment;Implant;implanted sensor;improved;improved mobility;Individual;innovation;Intervention;Intuition;Joints;Knee;Laboratories;Leg;Length;Life;Limb structure;Lower Extremity;Machine Learning;Measures;Methods;Mobility decline;Motion;Movement;Multiple Sclerosis;Muscle;Nerve;neuroprosthesis;noninvasive brain stimulation;operation;Orthotic Devices;Paresis;Participant;Pattern;Persons;Physical therapy;Physiologic pulse;Pilot Projects;post stroke;Predisposition;Preparation;Prosthesis;Protocols documentation;Quality of life;Rehabilitation therapy;Residual state;Risk Reduction;Safety;Scheme;sedentary lifestyle;Self-Help Devices;sensor;Sensory;Side;Signal Transduction;Social isolation;Speed;Spinal cord injury;stroke survivor;Surface;System;Techniques;Technology;Therapeutic;Thigh structure;Time;tool;Training;treadmill;Upper Extremity;Walking;walking speed;Weight;Work

PROJECT_TITLE: Customizable cooperative multi-joint control to enhance walking mobility after stroke

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Hypertension;Kidney Disease

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Kidney disease and hypertension affect more than 30 million and 70 million adults in the United States, respectively. There is an acute need to train dedicated scientists who will form the future workforce empowered to make discoveries, which lead to the reduction in death and disability from kidney disease and hypertension. The Division of Renal Diseases and Hypertension at the University of Colorado Anschutz Medical Campus T32 Training program provides state-of-the-art research training for MD and PhD scientists in both laboratory-based and clinical studies, with the goal of training the next generation of leaders in the field of nephrology research.

PI_NAMEs: JOHNSON, RICHARD JOSEPH;KENDRICK, JESSICA B (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TITLE: Renal and Electrolyte Disease and Hypertension


PI_NAMEs: BUI, ALEX  (contact)

PROJECT_TERMS: Architecture;Biomedical Research;California;career development;career networking;Collaborations;Communication;Communities;Computer software;Consensus;Development;digital;digital platform;Education;Ensure;Event;experience;Faculty;Fellowship Program;Fostering;Foundations;Funding;Future;Goals;Government;Growth and Development function;Hematology;high school;Home;Individual;Industry;Infrastructure;insight;Institution;Interdisciplinary Study;Kidney;Kidney Diseases;Learning;learning community;learning network;Link;Medical center;meetings;Mentors;Methods;Nongovernmental Organizations;online community;online repository;operation;Outcome;outreach;peer;peer networks;Persons;Postdoctoral Fellow;pre-doctoral;Process;programs;recruit;repository;Research Personnel;Research Training;Resources;Science;Site;Social Network;Students;success;symposium;System;TNFSF15 gene;tool;Training;Training Programs;undergraduate student;United States National Institutes of Health;Universities;Urology;Work

PROJECT_TITLE: Network Core


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Women's Health Research

ORG_CITY: NASHVILLE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: Project Narrative The potential for triple negative breast cancer (TNBC) to relapse and/or spread to other sites after therapeutic interventions depends on the ability of the tumor cells to reactivate growth and motility signals. In this study, we will determine how Annexin A6 promotes TNBC invasiveness and whether the increased expression of Annexin A6 following chronic tyrosine kinase inhibitor (TKI) treatment underlies the poor response of TNBCs to these drugs. Data from this study will improve our understanding of how TNBC cells circumvent the effects of chronic treatment with TKIs to become even more aggressive and/or invasive, key attributes which are associated with TNBC patient mortality.

PI_NAMEs: SAKWE, AMOS MALLE (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Annexin A6;Annexins;ANXA2 gene;Attenuated;Binding;Biochemical;Biological Assay;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;cancer invasiveness;Cancer Relapse;cancer subtypes;cell growth;cell motility;Cell Physiology;Chemoresistance;chemotherapy;Cholesterol;Chronic;clinically relevant;Complex;Data;Degenerative polyarthritis;Development;Drug resistance;Epidermal Growth Factor Receptor;Experimental Models;extracellular;Growth;Heterogeneity;Histones;improved;Incidence;late endosome;live cell imaging;Malignant - descriptor;Malignant Breast Neoplasm;Mediating;Medical;Membrane;Modification;mortality;Motility;Neoplasm Metastasis;neoplastic cell;NF-kappa B;NFKB Activation Pathway;novel;p65;Pathway interactions;Pharmaceutical Preparations;Play;Prognosis;Property;Proteins;Publishing;racial disparity;Relapse;Resistance;response;response biomarker;rho GTP-Binding Proteins;Role;Signal Transduction;Site;Testing;Therapeutic Intervention;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor progression;Tumor Suppressor Proteins;tumorigenic;Tyrosine Kinase Inhibitor;Up-Regulation

PROJECT_TITLE: Mechanisms of Annexin A6 Mediated Basal-like Breast Cancer Progression


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Structural Basis of APOBEC Functions and HIV Restriction  The APOBEC (Apolioprotein B mRNA-editing enzyme catalytic polypeptide) family of cytidine deaminases have diverse important biological functions that include (but not limited to) innate and aquired immunity against HIV/AIDS and other viruses such as HPV and HBV, cholesterol matabolism, heart and skeletal muscle development. Such divserse biological functions are excerted though their ability to interact with nucleic acids (RNA and DNA) and other proteins, either without or with the cytidine deamination activity that may also lead to accidental mutations that can lead to human deseases including immune defficiency and cancer. We propose to study the structure/function of the important family of APOBEC enzymes with focus on their functions related to virus (HIV-1) restriction, which will be valuable for for developing new effective therapies for HIV/AIDS and for the APOBEC-associated diseases and multiple cancers.

PI_NAMEs: CHEN, XIAOJIANG S (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: 3-Dimensional;Accidents;Address;Affinity;Anti-HIV Agents;Antibodies;antiviral immunity;apoB mRNA editing catalytic subunit;APOBEC2 gene;apolipoprotein B mRNA editing enzyme;Binding;Biological;Biological Process;Biology;C-terminal;Cardiac;Cell Physiology;Cholesterol;Cholesterol Homeostasis;cofactor;Complementary DNA;Complex;Cryoelectron Microscopy;Cullin 5 Protein;Cytidine;Cytidine Deaminase;Cytosine deaminase;Deaminase;Deamination;Disease;DNA;DNA Viruses;drug development;effective therapy;elongin B;Enzymes;Family;Generations;genome integrity;Genome Stability;Genomic Instability;Genomics;Goals;Hepatitis B Virus;HIV;HIV Infections;HIV therapy;HIV-1;HIV/AIDS;Human;human disease;Human Genome;Human Papillomavirus;Hyperimmunoglobulin M Syndrome;Immune response;Immune System Diseases;Immunity;immunodeficiency;Immunoglobulin Class Switching;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;Infection;Length;Malignant Neoplasms;Mediating;member;Messenger RNA;Molecular;multicatalytic endopeptidase complex;Muscle Development;Mutation;Myocardium;N-terminal;Natural Immunity;novel;Nucleic Acids;Outcomes Research;pathogenic virus;Play;polypeptide;prevent;Proteins;recruit;Regulation;Research;Retroelements;Retrotransposition;Retroviridae;Reverse Transcription;Risk;RNA;RNA Binding;RNA Viruses;RNA-Directed DNA Polymerase;Roentgen Rays;Role;Single-Stranded DNA;Skeletal Muscle;Specificity;Structure;Substrate Specificity;ubiquitin-protein ligase;Ubiquitination;Uridine;Viral;viral genomics;Viral Physiology;Virion;Virulent;Virus;Virus Diseases;Virus Replication

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]