ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Prevention;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Narrative This research projects intends to fully develop the theranostic capabilities of a targeted fluorescence imaging probe, PSMA- 1-Pc413, that has been used for image guided surgery and photodynamic therapy. This will be accomplished using a syngeneic mouse model of prostate cancer to perform image guided surgery and PDT measuring its stimulation of the immune system. A canine model will be utilized to perform imaged guided surgery followed by PDT and measure collateral damage to surrounding tissues.

PI_NAMEs: BASILION, JAMES PETER (contact);WANG, XINNING

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: Ablation;Address;Adjuvant;Animals;Antigen Receptors;Antigen Targeting;Biochemical;Biodistribution;Biological Markers;C57BL/6 Mouse;cancer cell;Cancer Etiology;Cancer Patient;cancer recurrence;Cancerous;canine model;Canis familiaris;Cells;Cessation of life;Chemotherapy and/or radiation;Clinical;clinical application;clinical translation;Clinical Treatment;Clinical Trials;Development;Diagnosis;Disease;Dose;drug development;Drug Kinetics;efficacy trial;Energy Transfer;Excision;Failure;Feedback;Fluorescence;fluorescence imaging;fluorescence-guided surgery;FOLH1 gene;Foundations;Future;Gland;Goals;high risk;Histopathology;Human;Image-Guided Surgery;imaging probe;Immune response;Immune system;Immunocompetent;Immunologic Monitoring;Immunologic Stimulation;Immunomodulators;Impotence;improved;Incontinence;Injections;innovation;Institution;Invaded;irradiation;Ligands;Light;male;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Metastatic/Recurrent;Microscopic;minimally invasive;Modeling;Molecular;molecular imaging;Morbidity - disease rate;mouse model;Movement;Mus;Muscle;Muscle Cells;Neoplasm Metastasis;Nerve;Nerve-Sparing Surgery;Neurons;Normal Cell;Normal tissue morphology;novel;Operative Surgical Procedures;Oxygen;Pathologic;Pathology;Patients;Pharmaceutical Preparations;Photosensitizing Agents;Physiology;Postoperative Period;prevent;Procedures;Progression-Free Survivals;Prostate;Prostate Ablation;prostate cancer cell;prostate cancer model;prostate cancer risk;Prostatectomy;Prostatic Diseases;Prostatic Neoplasms;PUVA Photochemotherapy;Radiation therapy;Radical Prostatectomy;Reactive Oxygen Species;Recurrence;Recurrent tumor;relapse prevention;Reporting;Research Project Grants;Resected;screening;serum PSA;side effect;skin disorder;success;Surgeon;Surgical margins;System;targeted treatment;Techniques;Technology;Testing;theranostics;Therapeutic;Time;Tissues;Transducers;Treatment Efficacy;Treatment outcome;treatment response;tumor;tumor diagnostic;United States;Unresectable;uptake;Urologic Surgeon;Visualization;Work

PROJECT_TITLE: Fluorescence image guided surgery, adjuvant PDT, and the immune response


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Neurosciences;Nutrition;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PISCATAWAY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Concussion, or mild traumatic brain injury (mTBI), is the most common neurological condition seen in both children and adults, and the incidence of concussions is increasing with a growing awareness of the possible consequences of repetitive concussions on brain health. We identified a protein that protects cognition and accelerates recovery after moderate TBI. The current studies will address whether therapeutics that target this protein can be used to promote recovery after a single mild TBI, paving the way for future drug development for human use.

PI_NAMEs: FIRESTEIN, BONNIE L (contact);MEANEY, DAVID F

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acceleration;Adenosylhomocysteinase;Adult;Affect;Aging;Alzheimer's disease model;Atlases;Attenuated;Awareness;Binding;Brain;Brain Concussion;brain health;Brain Injuries;brain metabolism;Cause of Death;Cell Nucleus;cell type;Cells;Child;Cognition;Cognitive deficits;Complex;Cytoskeleton;Data;Development;dietary;dietary restriction;disability;Disputes;DLG4 gene;drug development;Economic Burden;Elderly;excitatory neuron;excitotoxicity;experimental study;Future;Glutamates;Guanine;guanine deaminase;Hippocampus;Homocysteine;Human;Impaired cognition;improved outcome;In Vitro;in vivo;Incidence;Injury;Life;Light;Link;Literature;Mediating;Metabolic;metabolic profile;Metabolism;Methionine;Methionine Metabolism Pathway;methionine sulfoxide;mild traumatic brain injury;Modeling;Molecular;Molecular Target;Monitor;Morbidity - disease rate;mouse model;Mus;mutant;Natural regeneration;Nervous System Disorder;Neurocognition;Neurologic;neuronal metabolism;Neurons;neuroprotection;novel;Pathway interactions;Patients;Play;Post-Concussion Syndrome;Production;Prognostic Marker;Proteins;Publishing;purine metabolism;Recovery;Recovery of Function;Regulation;Reporting;Risk;Rodent;Rodent Model;Role;Serum;side effect;single nucleus RNA-sequencing;small molecule;Societies;Survivors;Synaptic plasticity;TBI Patients;Testing;Therapeutic;therapeutic target;transcriptome sequencing;Traumatic Brain Injury;treatment strategy;Uric Acid;Work;Xanthines

PROJECT_TITLE: Metabolic Mechanisms of Recovery in Mild TBI

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Mental Health;Pain Research;Social Determinants of Health;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Chronic orofacial pain conditions are unified by high levels of pain-related disability, maladaptive coping (e.g., fear avoidance and catastrophic thinking about pain) and emotional distress (e.g., depression and anxiety). The proposed study will develop, iteratively refine, and establish the feasibility, acceptability and credibility of Face-Forward-Web, the first psychosocial intervention developed through mixed-methods, designed specifically for adults with heterogeneous chronic orofacial pain, and delivered through web-platform (this population’s preferred treatment modality). Face-Forward-Web bypasses key accessibility and scalability-related limitations of existing interventions (including challenges with talk- based therapy, which is often painful and limits engagement in this population) and has the potential to dramatically improve pain, pain-related activity limitations and distress in this population.

PI_NAMEs: GREENBERG, JONATHAN  (contact);VRANCEANU, ANA-MARIA

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Affect;Agreement;Anxiety;Behavioral Model;Behavioral Sciences;Benchmarking;Bypass;Chronic;Clinical Trials;Cognitive Therapy;Communication;coping;cost;craniofacial;Data;Dentists;design;Development;Diagnosis;Distress;Effectiveness;efficacy study;efficacy testing;emotional distress;Ensure;Etiology;evidence base;Evidence based program;Expectancy;experience;Face;Facial Pain;Feedback;Focus Groups;Fright;Future;Goals;Health;improved;Individual;information gathering;Insurance Coverage;Internet;Intervention;Interview;Measurement;Medical;member;Mental Depression;Mental Health;Methods;mindfulness;Modality;Modeling;multi-component intervention;multimodality;National Institute of Dental and Craniofacial Research;Neurologist;novel;Online Systems;Orofacial Pain;Outcome;Pain;pain catastrophizing;Pain management;pain outcome;pain-related disability;Participant;Patients;Persons;Phase;Pilot Projects;Population;preference;Preparation;Procedures;programs;Protocols documentation;prototype;Provider;psychiatric comorbidity;Psychologist;psychosocial;Psychosocial Factor;Questionnaires;Randomized;recruit;Refractory;Relaxation;Reporting;Research Design;Research Support;resilience;Resources;response;satisfaction;Science;Series;side effect;social stigma;Strategic Planning;Technology;Temporomandibular Joint Disorders;Testing;theories;therapy development;Thinking;Time;Training;Travel;underserved community;United States National Institutes of Health;user centered design;web platform;Work

PROJECT_TITLE: Development of "Face-Forward-Web": A novel web-based program targeting pain-related outcomes among patients with heterogeneous chronic orofacial pain

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: Nashville

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Abasic sites in DNA arise spontaneously and as a consequence of many environmental sources including oxidizing agents, nitrosamines, and radiation. In this project we study the mechanisms that recognize and repair these lesions with a focus on a new pathway that we discovered that acts to protect abasic sites in single-stranded DNA from deleterious processing. Completing this project will provide a molecular understanding of how cells manage a common form of DNA damage that is formed in response to many environmental agents.

PI_NAMEs: CORTEZ, DAVID K (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Acute;adduct;Aging;Agrochemicals;Air Pollution;Alkylating Agents;Alkylation;Bacteria;base;Base Excision Repairs;Binding;Biochemical;Bypass;Carbon;Cell Extracts;Cells;Chemicals;Chloroform;Clinical;coping;coping mechanism;Coupled;crosslink;Cysteine;Cytosine;Data;Detergents;Diet;Disease;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA lesion;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;DNA-protein crosslink;embryo cell;endonuclease;environmental agent;Exposure to;Failure;Food;Frequencies;Future;Genetic;genetic approach;Genome;Genome Stability;Genotoxic Stress;Guanine;Health;Human;Hydroxyl Radical;improved;In Vitro;Ionizing radiation;Laboratories;Lesion;Maintenance;Malignant Neoplasms;manufacture;Mediating;Methylation;Modeling;Molecular;Mutagenesis;Mutagens;Mutation;N-terminal;Nitrosamines;Organism;Oxidants;oxidation;Oxidative Stress Induction;Pathway interactions;Plastics;Polymerase;Positioning Attribute;potassium bromate;prevent;Process;Proteins;Proteolysis;Radiation;Reaction;Regulation;repaired;Research Personnel;Research Project Grants;Resolution;response;S phase;Self Direction;Single-Stranded DNA;Site;Solvents;Source;System;Tertiary Protein Structure;Testing;Time;Toxic Environmental Substances;Ubiquitin;UV Radiation Exposure

PROJECT_TITLE: Function of HMCES in abasic site repair and tolerance

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Most patients who undergo surgery to remove liver cancers experience recurrence of their cancer within a few years. We are conducting a clinical trial of immunotherapy before potentially curative surgery for liver cancer, and are investigating the effect of a brief course of immunotherapy on the removed cancers, to understand if immunotherapy can change the cancers to improve cure rates.

PI_NAMEs: HO, WON JIN ;YARCHOAN, MARK  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: 3-Dimensional;Activated Lymphocyte;Adjuvant;Aftercare;anti-PD-1;Antigens;arm;B-cell receptor repertoire sequencing;B-Lymphocytes;bevacizumab;Bypass;Cancer Etiology;CD8-Positive T-Lymphocytes;Cells;Cellular Structures;Clinical;Clonal Expansion;Computational algorithm;Curative Surgery;Cytometry;Data;density;Early treatment;effector T cell;Excision;experience;Future;Genetic Transcription;global health;Goals;Granzyme;Image;Immune;Immune response;Immunophenotyping;immunoregulation;Immunotherapy;immunotherapy clinical trials;improved;improved outcome;Individual;inhibitor;KDR gene;kinase inhibitor;liver cancer model;Lymphoid;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;mortality;multiplexed imaging;Myelogenous;Myeloid Cells;Nature;Needle biopsy procedure;Neoadjuvant Study;Neoadjuvant Therapy;new technology;Nivolumab;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;participant enrollment;Pathologic;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;Perioperative;pre-clinical;Pre-Clinical Model;prevent;Primary carcinoma of the liver cells;Primary Neoplasm;programmed cell death protein 1;programs;reconstruction;recruit;Recurrence;Recurrent disease;RELA gene;Relapse;response;Signal Transduction;Site;Source;spatial relationship;Specimen;Structure;Systemic Therapy;T cell receptor repertoire sequencing;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;tertiary lymphoid organ;Testing;Therapeutic;therapy resistant;three-arm study;trafficking;treatment response;tumor;Tumor Immunity;tumor-immune system interactions;United States

PROJECT_TITLE: Neoadjuvant Immunotherapy Platform Study Reveals Mechanisms of Response in Hepatocellular Carcinoma (HCC)

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: AG

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The rigorous study of factors that contribute to life-course health and aging of the immigrant population in the US cannot be examined adequately based on US data sources alone. This project will establish and analyze linked samples of households in origins and destinations using conventional as well as innovative sampling designs and unique administrative data on sensitive life-stage exposures. Data from this project will improve the understanding of the countervailing forces promoting and undermining Sub-Saharan African immigrant health over time using Ghana as a case study, from where migrant flows to the U.S. have been considerable and increasing in recent decades.

PI_NAMEs: BAWAH, AYAGA A;FLIPPEN, CHENOA ANNE;MERLI, GIOVANNA M (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Academy;Acculturation;Affect;Africa South of the Sahara;African;Aging;American;Area;Black Populations;Black race;Caribbean region;Case Study;Censuses;Collaborations;Community Surveys;Country;Cross-Sectional Studies;Data;Data Sources;design;Destinations;Development;Discrimination;Economic Conditions;Economics;Ensure;Environment;Ethnic Origin;experience;Exposure to;Family;follow-up;Ghana;Health;Health behavior;Health behavior and outcomes;health care availability;health economics;Healthcare;Heterogeneity;Home;Household;human old age (65+);Immigrant;improved;innovation;Institution;instrument;Interview;Investigation;Knowledge;Latin America;Life;Life Cycle Stages;Life Style;Link;Maps;Measures;member;Memory;Mental Depression;Mental Health;Methods;middle age;Migrant;migration;National Health Interview Survey;Native-Born;Nonmigrant;novel strategies;Out-Migrations;Outcome;perceived discrimination;physical conditioning;Population;Probability;Process;Protocols documentation;Race;racial minority;Recommendation;recruit;Research;Resources;Respondent;Role;Sampling;Schools;Shapes;Site;social contact;social determinants;Social Network;socioeconomics;Source;Stress;success;support network;Surveys;Testing;Time;time use

PROJECT_TITLE: Dynamics of Ghanaian immigrants' health in the US: Critical life-stage experiences, social networks, acculturation and selection (GMHeS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M1)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Sleep Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative Thalamocortical communications underlie processes of perception, attention, memory, emotions, and the sleep- wake cycle, and are disrupted in schizophrenia, but the underlying mechanisms of pathology are unknown. The goals of the proposed research project are to test the hypotheses that focal “core” and more widespread “matrix” thalamocortical pathways are differentially affected in schizophrenia, through mechanisms that involve distinct changes in their structure, physiology, and laminar interactions with cortical inhibitory neurons in medial, orbital, and lateral prefrontal cortices. Findings will help us model typical and abnormal brain function and provide the foundation to understand heterogeneous disruption of these networks in sleep disorders, attention deficits, and cognitive and affective impairments in schizophrenia, with important implications for the design of targeted therapeutic interventions.

PI_NAMEs: YAZDANBAKHSH, ARASH ;ZIKOPOULOS, VASILEIOS  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Accounting;Address;Adult;Affect;Affective;Area;Attention;Attentional deficit;attentional modulation;Autopsy;Axon;biophysical model;Brain;brain dysfunction;brain tissue;calbindin;Calcium-Binding Proteins;Caliber;Cell Nucleus;Cognition;Cognitive;cognitive process;Communication;Computer Models;Data;density;design;Diffuse;Disease;Emotions;Equilibrium;excitatory neuron;Exhibits;First Independent Research Support and Transition Awards;flexibility;Foundations;Functional disorder;Goals;Health;Human;Image;Impairment;Individual;inhibitory neuron;Injections;innovation;Internal Capsule;Interneurons;Label;Lateral;Link;Macaca mulatta;Medial;Memory;Mental disorders;Microscopy;Modeling;Monkeys;multimodality;myelination;nerve supply;neural;neural network;neurochemistry;Neurons;Noise;novel;Nuclear;Outcome;Parvalbumins;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Perception;Physiological;Physiology;Prefrontal Cortex;Primates;Process;receptor;recruit;Research Project Grants;Resolution;response;Schedule;Schizophrenia;schizophrenia spectrum disorder;Sensory;Sensory Process;sensory system;Signal Transduction;Sleep;Sleep Disorders;Sleep Wake Cycle;Specificity;Speed;Structure;Synapses;System;targeted treatment;Testing;Thalamic structure;Therapeutic Intervention;Tissues;Tracer;Travel;Variant;vigilance;white matter;Work

PROJECT_TITLE: Organization and Circuit Interactions of Thalamocortical Attentional Networks in Health and Disease

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Hexokinase 2 (HK2), which catalyzes the first committed step in glucose metabolism, is not expressed in most normal adult tissues but is induced in cancer cells. We found that HK2 is also induced in activated hepatic stellate cells and is required for fibrosis. The role of HK2 in liver fibrosis and NASH-induced HCC will be explored.

PI_NAMEs: HAY, NISSIM  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Acetates;Acetylation;Actins;Address;Adult;aerobic glycolysis;Affect;Affinity;Applications Grants;Attenuated;bile duct;cancer cell;Cancer Etiology;Citric Acid Cycle;Collagen;Compensation;cytokine;cytotoxic CD8 T cells;Development;Fibrosis;Gene Expression;gene induction;Genes;Genetic;Glucokinase;Glucose;glucose metabolism;Glutamine;Glycolysis;Hepatic Stellate Cell;Hepatocarcinogenesis;Hepatocyte;hexokinase;Hexokinase 2;Histone Acetylation;Histone Deacetylase;Histones;Impairment;in vivo;Isotope Labeling;Ligation;Liver Fibrosis;liver injury;Mediating;Metabolic;Metabolic dysfunction;mortality;mouse model;Mus;nonalcoholic steatohepatitis;Patients;Physiological;Play;Primary carcinoma of the liver cells;Production;Role;single-cell RNA sequencing;Smooth Muscle;Steatohepatitis;Therapeutic;Time;Tissues;tumor microenvironment;tumorigenic

PROJECT_TITLE: The role of hexokinase 2 in liver fibrosis and NASH-induced HCC

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE We aim to increase the number of Latinas meeting and adhering to physical activity guidelines by integrating stress reduction strategies into their daily life. If women do not meet guidelines, we will provide them with additional help to manage their stress, partly through mindful movement. Meeting and adhering to guidelines at 18 months will improve their heart health.

PI_NAMEs: MARCUS, BESS HYA (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Accelerometer;Acculturation;Address;Adherence;Adopted;aged;arm;Attention;Behavior;behavioral health;Biological Markers;Blood Pressure;Cardiac health;cardiovascular health;care giving burden;Chronic Disease;Communities;comorbidity;cost;Counseling;design;Discrimination;Disparity;disparity reduction;Ecological momentary assessment;empowerment;evidence base;Evidence based intervention;exercise intervention;experience;fitbit;General Population;Glycosylated hemoglobin A;Goals;Guidelines;Habits;Health;Health behavior;Health behavior and outcomes;Health Benefit;health disparity;Home;Hydrocortisone;improved;Incidence;innovation;Intervention;intervention effect;Investments;Laboratories;Latina Population;Life;life span;Lipids;marginalized community;Measures;Mediator;meetings;mindfulness;Mindfulness Training;mindfulness-based stress reduction;Movement;Neighborhoods;Outcome;Participant;Patient Self-Report;Persons;Physical activity;Population;Population Group;Populations at Risk;Premature Mortality;Prevention;Process;programs;Psyche structure;Psychosocial Stress;Randomized;Recommendation;Reduce health disparities;Regimen;remote delivery;remote technology;Research;Research Design;Resources;Science;social stigma;Stress;stress management;stress reduction;stressor;Techniques;Technology;Testing;theories;Time;tool;Underserved Population;United States National Institutes of Health;wasting;Weight;Woman;Work

PROJECT_TITLE: Improving Physical Activity Participation in Latinas with Mindfulness

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE  The Müller glial cells within the retina of non-mammalian species can regenerate retinal neurons and reverse blindness, while mammalian retinae cannot. We have recently determined that the Hippo signaling pathway functions as a molecular block to Müller glial cell-mediated retinal regeneration in mice, but the precise molecular inputs regulating this response are unknown. By uncovering the mechanism of Hippo pathway regulation specifically in Müller glia, we will establish new therapeutic targets to manipulate this pathway to promote mammalian retinal regeneration to treat blindness.

PI_NAMEs: POCHE, ROSS ANTHONY (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Affinity Chromatography;Age related macular degeneration;Alkynes;Amino Acids;Biochemical;Biophysics;Biotin;Blindness;Bypass;CCND1 gene;Cell Cycle;cell injury;Cell Nucleus;Cell Reprogramming;cell type;Cells;Cessation of life;Chemistry;clinical translation;cofactor;Cyclin D1;Data;Endogenous Factors;Ensure;Event;excitotoxicity;experimental study;Foundations;Future;ganglion cell;Gene Expression;Genes;Genetic Transcription;Glaucoma;Glial Cell Proliferation;Gliosis;in vivo;Inflammation;Investigation;Label;Lead;Mass Spectrum Analysis;Mediating;Metabolic;Methionine;Methionine-tRNA Ligase;Molecular;Muller's cell;Mus;mutant;N-Methylaspartate;Natural regeneration;Neuroglia;neuron loss;neuronal survival;Neurons;neuroprotection;new therapeutic target;Nitrosourea Compounds;novel therapeutic intervention;Nuclear;Oncogenes;Pathway interactions;Peptide Synthesis;Phosphorylation;Photoreceptors;prevent;progenitor;programs;protein purification;Proteins;Proteome;Reaction;regeneration potential;regenerative;Regenerative response;Regulation;repaired;Repression;Research;response;Retina;retinal damage;Retinal Degeneration;Retinal Ganglion Cells;retinal neuron;retinal regeneration;Rhodopsin;Rod;Role;sight restoration;Signal Pathway;Signal Transduction;stem cell differentiation;System;Therapeutic;Therapeutic Intervention;therapeutic target;therapy development;Time;Transgenic Mice;Traumatic injury;Variant;Vision;Withdrawal;Zebrafish

PROJECT_TITLE: Characterization of the nascent retinal proteome regulating Hippo signaling during damage

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Health Services;Human Genome;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative This project seeks create a Diagnostic Center of Excellence (DCoE) for Phase III of the Undiagnosed Diseases Network (UDN). Our DCoE will focus on using community-engaged participatory research approach to assure that the UDN is serving diverse and disadvantaged communities. Our DCoE will also seek to improve UDN sustainability and the case solve rate by providing innovative approaches.  .

PI_NAMEs: BALWANI, MANISHA ;GELB, BRUCE D (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Adult;Advocate;Algorithms;Area;Artificial Intelligence;Autoimmune;autoinflammatory;Biomedical Research;Candidate Disease Gene;cell type;Childhood;Cities;Clinical;Clinical Research;Collaborations;Communities;community based participatory research;community engaged research;community engagement;community partners;Complex;congenital immunodeficiency;Data;deep sequencing;Diagnostic;Disease;DNA sequencing;Drosophila genus;Ecosystem;Enrollment;Equity;Exclusion Criteria;exome;experience;Family health status;Federally Qualified Health Center;functional genomics;Genes;Genetic;Genetic Diseases;Genetic Services;genetic variant;Genome;genome sequencing;Genomic approach;Genomic medicine;Genomics;Geography;Germ Lines;Goals;Health system;Human Genetics;Immune;Immune system;Immune System Diseases;immunodeficiency;Immunologic Monitoring;Immunologics;Immunophenotyping;improved;In Vitro;inclusion criteria;Infant;innovation;Institution;Lead;Learning;Leukocytes;Medical Genetics;medical schools;Medicine;Mendelian disorder;metropolitan;Modeling;Mosaicism;neighborhood disadvantage;Neurology;New York City;outreach;Participant;Pathogenesis;Patient Care;Patients;Pediatrics;peripheral blood;Persons;Phase;Phenotype;Physicians;Planet Earth;Population Heterogeneity;programs;recruit;Research;Research Personnel;routine screening;Site;Standardization;success;trait;transcriptome sequencing;United States National Institutes of Health;Urban Population;Variant;Work

PROJECT_TITLE: Mount Sinai Center for Undiagnosed Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (21)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: MADISON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This project—the Future of Families and Child Wellbeing (FF) Third Generation Children’s Study—will collect data on the third generation of the FF study. We will collect information on family/caregiving context, parenting and grandparenting behaviors, and child development for all children born to female members of the original birth cohort as these children reach age 5. The data will facilitate novel and important analyses of intergenerational transmission of parenting behaviors, relationships within families, child development, and gene*environment influences on social and economic wellbeing, including health.

PI_NAMEs: BERGER, LAWRENCE M (contact)

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Achievement;Age;Attention;Award;Behavior;Behavioral;Biological;Biological Factors;Birth;Black race;Book Chapters;Books;caregiving;Child;Child Development;Child Health;Child Rearing;Child Welfare;Cognition;cohort;Cohort Studies;Communities;Comprehension;COVID-19 pandemic;Data;data access;Data Collection;Data Sources;Development;Disadvantaged;distraction;DNA;Documentation;early childhood;Economic Factors;Economics;Emotional;Ensure;Environment;Environmental Risk Factor;Epigenetic Process;Ethnic Origin;executive function;Family;Family member;Fathers;Female;Future;Gender;Generations;Genes;grandparent;Health;Health Policy;Heterogeneity;Hispanic;Household;Inequality;Infant;innovation;intergenerational;journal article;Knowledge;member;Mothers;novel;Outcome;pandemic disease;Paper;Parents;Pattern;Perinatal;Personal Satisfaction;Policies;Population;population based;Population Characteristics;Population Study;post-COVID-19;pregnant;prenatal;Public Health;Race;Research;Research Personnel;Resources;Respondent;response;Sampling;Siblings;social;social factors;Social Policies;Social Well-Being;sociodemographics;socioeconomic disparity;Subgroup;Surveys;Time;transmission process;United States;virtual assessment;Woman;young adult

PROJECT_TITLE: The Future of Families and Child Wellbeing Third Generation Children’s Study

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Neurosciences;Rare Diseases

PHR: PROJECT NARRATIVE Our lab uses the immune system to treat cancer by reprogramming patients’ immune cells (T cells) to target and kill tumor cells. We developed T cells to treat glioblastoma (GBM), a deadly brain tumor, by directly killing tumor cells and releasing a molecule to help other T cells kill tumor cells. Based on their effectiveness in mouse models of GBM, we are initiating a clinical trial to treat GBM patients and will perform extensive studies to understand how this new therapy works in humans. This therapy will potentially improve GBM patient outcomes and provide valuable data on how to use these cells to treat other tumor types.

PI_NAMEs: CHOI, BRYAN ;MAUS, MARCELA VALDERRAMA (contact)

PROJECT_TERMS: Adverse event;Aftercare;Antibodies;Antigen Targeting;Antigens;Back;Binding;Biopsy;Blood;Blood Cells;Blood specimen;Brain;Brain Neoplasms;cancer cell;Catheters;cell killing;Cell Physiology;Cell Proliferation;Cell secretion;cell type;Cells;Cerebrospinal Fluid;Chemoresistance;chimeric antigen receptor;chimeric antigen receptor T cells;Circulation;Clinical;Clinical Trials;Correlative Study;cytokine;Data;Disease;Disparity;effective therapy;Effectiveness;Engineering;Engraftment;Enrollment;Ensure;Epidermal Growth Factor Receptor;Foundations;Funding;Future;Gene Expression Profile;Gene Modified;Glioblastoma;Goals;Hematologic Neoplasms;Human;Immune;Immune system;Immunotherapy;improved;improved outcome;In Vitro;in vivo evaluation;Infiltration;Injections;insight;Intraventricular;Killer Cells;Malignant Neoplasms;Measures;Modification;Monitor;mouse model;Mus;Mutate;Mutation;Myeloid Cells;Natural Killer Cells;neoplastic cell;Newly Diagnosed;Normal tissue morphology;novel;novel therapeutics;Ommaya Reservoir;Patient Care;Patient Monitoring;Patient-Focused Outcomes;Patients;Peripheral;peripheral blood;Persons;Phase I Clinical Trials;Phenotype;pre-clinical;pressure;programmed cell death ligand 1;receptor;Recurrence;Regulatory T-Lymphocyte;Research;Resistance;response;Safety;safety and feasibility;Sampling;Series;side effect;Signal Transduction;Site;Skin;Solid Neoplasm;standard of care;success;Survival Rate;T cell infiltration;T-Cell Activation;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Toxic effect;trafficking;treatment response;tumor;Tumor Antigens;tumor growth;tumor heterogeneity;tumor microenvironment;Tumor Suppression;Tumor Tissue;United States National Institutes of Health;Variant;Work;Xenograft Model

PROJECT_TITLE: Bioactivity of CAR T cells secreting T cell engager-anitbodies in humans with glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE Even though cognitive deficits in schizophrenia and related psychotic disorders have an enormous impact on human health and disability, many patients do not show any cognitive improvement with current antipsychotic medications. Thus, there exists an urgent need to develop insight into the neural substrates and neuroplasticity mechanisms underlying cognition and the discovery of novel antipsychotic medications with the potential to lead to cognitive improvement. This proposal uses innovative, patient-derived iPSC and cerebral organoid techniques to ask mechanistic questions concerning the role of Arc-dependent neuroplasticity in psychotic disorders using high-resolution imaging and functional genomic methods in concert with parallel analysis of clinical outcomes of first-episode psychosis patients treated with lurasidone; it is likely to be of high impact because it focuses on human disease neurobiology in relation to the early stage of psychosis and cognitive deficits in schizophrenia, thereby helping lay a foundation for advancing precision medicine.

PI_NAMEs: HAGGARTY, STEPHEN J;KARMACHARYA, RAKESH  (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: Address;Adult;Animals;Antipsychotic Agents;atypical antipsychotic;behavioral study;Biological Assay;Bipolar Disorder;cell cortex;Cells;Cerebrum;chemical synthesis;Clinical;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;Cognitive;Cognitive deficits;cognitive enhancement;cognitive performance;cohort;Collaborations;Collection;comparative;Critical Pathways;Cytoskeleton;Data;Delusions;Dendritic Spines;density;design;disability;Disease;efficacious treatment;Electrophysiology (science);Enhancers;Equilibrium;Exhibits;exome sequencing;first episode psychosis;first episode schizophrenia;Foundations;Functional disorder;functional genomics;functional outcomes;Genetic;genome wide association study;Glutamates;Hallucinations;Health;high resolution imaging;Human;human disease;human induced pluripotent stem cells;Image;imaging platform;Impaired cognition;Impairment;improved;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;innovation;insight;Learning;Libraries;loss of function;Measurement;Mediating;Memory;memory consolidation;Memory impairment;Messenger RNA;Methods;MK801;Molecular;multi-electrode arrays;multidisciplinary;Mus;N-Methyl-D-Aspartate Receptors;neural;neural network;Neurobiology;Neuronal Plasticity;Neurons;neuropsychiatric disorder;NMDA receptor antagonist;novel;novel therapeutic intervention;Organoids;Outcome;overexpression;Pathway interactions;patient derived induced pluripotent stem cells;patient response;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phenotype;pre-clinical;precision medicine;prevent;Property;protein complex;protein expression;protein function;Proteins;Psychoses;psychotic;Psychotic Disorders;Publications;Quantitative Structure-Activity Relationship;response;Rodent;Role;Schizophrenia;side effect;small molecule;stem cell model;Structure-Activity Relationship;Synaptic plasticity;System;Techniques;Technology;Testing;Therapeutic;Training;transcriptome;treatment response;ziprasidone

PROJECT_TITLE: Targeting Arc to Improve Cognitive Deficits in Psychotic Disorders

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE We seek to increase the clinical acceptance of the novel vaccine platform PARVAX by understanding the mechanisms behind its potency and durability, by improving the platform and by testing the efficacy of novel vaccine candidates for other pathogens. The proposed work is highly relevant for pandemic preparedness, since it will derisk the PARVAX platform enabling the rapid design of new candidates for existing and future pathogens. Moreover, the proposed studies will provide insight on the means to improve the durability, breadth and mucosal immunity of other platforms.

PI_NAMEs: ZABALETA, NEREA  (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;adaptive immunity;Address;Adenoviruses;Affinity;Antibodies;Antibody Response;Antigen-Antibody Complex;Antigen-Presenting Cells;Antigens;B-Lymphocytes;Capsid;Cavia;Cell Maturation;Cells;cellular transduction;Characteristics;Clinical;clinically relevant;Cold Chains;Complex;cost;COVID-19;COVID-19 pandemic;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Dependovirus;Deposition;design;DNA;Dose;efficacy study;efficacy testing;Engineering;Enhancement Technology;epidemic potential;Exhibits;Future;future epidemic;gene therapy;Gene Transfer;Genes;genetic vaccine;Genome;Human;Humoral Immunities;Immune;immune activation;Immunity;immunogenicity;Immunologics;improved;Infection;Influenza A Virus, H1N1 Subtype;influenza infection;influenzavirus;insight;Intramuscular;Kinetics;manufacturing cost;manufacturing process;Memory;Messenger RNA;Modeling;Mucosal Immunity;Mucous Membrane;Mus;Natural Immunity;nonhuman primate;novel;novel vaccines;Osmosis;pandemic disease;pandemic pathogen;pandemic preparedness;pathogen;Pathway interactions;Pattern;Peptides;pre-clinical;Pre-Clinical Model;Prevention;Preventive vaccine;promoter;prototype;Pump;Recombinants;response;RNA vaccine;Safety;safety study;SARS-CoV-2 antigen;Serotyping;Serum;Specificity;Structure of germinal center of lymph node;Surface;T cell response;Technology;technology development;thermostability;Time;TLR9 gene;Transgenes;transmission process;Tropism;vaccination outcome;vaccine candidate;vaccine efficacy;vaccine platform;Vaccines;vector;Work

PROJECT_TITLE: Characterization and optimization of single dose, thermostable and durable vaccine platform towards increased clinical acceptance

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: GENETICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Alzheimer’s disease is the most common neurodegenerative disease and the leading cause of dementia. No cures or disease-modifying treatments are available. The goal of this research is to identify mechanisms underlying the selective vulnerability of norepinephrine-containing neurons in the brain that degenerate in Alzheimer’s disease and mediate prodromal and cognitive symptoms for the development of novel biomarkers and therapeutics.

PI_NAMEs: WEINSHENKER, DAVID  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Acceleration;Affect;Agitation;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease test;American;Animal Model;Animals;Anxiety;Apoptosis;Appearance;Arousal;Autopsy;Behavior;Behavioral;Behavioral Symptoms;Binding;Biological Markers;Brain;Brain region;Catecholamines;Cell Death;cell type;Cells;Chromatography;Clinical Research;Cognition;Cognitive;Cognitive deficits;Cytoplasm;Cytoplasmic Granules;Darkness;Dementia;Development;Disease;Electron Microscopy;Electrophysiology (science);Enzymes;Fiber;Fontana-Masson stain;Foundations;Functional disorder;Gene Expression;Gene Expression Alteration;genetic approach;Goals;Heavy Metals;histological stains;Human;human old age (65+);hyperphosphorylated tau;Image;Immunohistochemistry;Impaired cognition;improved;in vivo;Inflammation;insight;life span;Link;Lipids;Liquid substance;locus ceruleus structure;Magnetic Resonance Imaging;Mediating;Melanins;Memory impairment;Memory Loss;Mental Depression;Metabolism;Methods;Monophenol Monooxygenase;Morphology;Mus;Nerve Degeneration;Neurobehavioral Manifestations;Neurobiology;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuromelanin;Neurons;neuropathology;Neurotoxins;noradrenergic;Norepinephrine;novel;novel marker;novel therapeutics;Pathologic;Pathology;Performance;pharmacologic;Phenotype;Pigmentation physiologic function;Pigments;prevent;Primates;prodromal Alzheimer's disease;Production;protein aggregation;Proxy;Quality of life;Research;Rodent;Rodent Model;Role;Senile Plaques;Skin;Sleep disturbances;Slice;Structure;Study models;Substantia nigra structure;Symptoms;synergism;tau aggregation;tau Proteins;Testing;Time;Tissues;Toxic effect;Toxin;transcriptome sequencing;transmission process;Viral;Viral Vector;Visualization

PROJECT_TITLE: Contribution of neuromelanin to selective vulnerability of locus coeruleus neurons in Alzheimer's disease


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_DEPT: PATHOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Different bones, such as vertebrae each display both different biology and diseases processes, though the basis for these differences is unknown. Here, as a means to establish why vertebrae and limb bones display marked clinical and biologic differences, we will determine how a vertebral stem cell we have discovered governs the physiology of bone formation in the spine.

PI_NAMEs: GREENBLATT, MATTHEW BLAKE (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Address;Adipocytes;Alleles;analog;Architecture;Automobile Driving;Binding;Biological;Biology;bone;bone cell;bone mass;bone turnover;CD 200;Cell Lineage;Cell surface;cell type;Cells;Cellularity;Chondrocytes;Chromatin;Clinical;Data;Defect;Degenerative Disorder;developmental disease;Disease;Dorsal;ENG gene;Etiology;Functional disorder;Gene Deletion;Genetic;Genetic Transcription;Human;in vivo;Label;Ligands;limb bone;Literature;Location;long bone;Maintenance;Manuscripts;Mediating;Methods;mineralization;mouse model;Mus;Nature;Neoplasm Metastasis;neural;novel;Operative Surgical Procedures;Organoids;Orthopedic Procedures;Orthopedics;osteoblast differentiation;Osteoblasts;Osteogenesis;Outcome;Phenotype;Physiologic pulse;Physiological;Physiology;population based;postnatal;Process;progenitor;programs;Property;Protein Secretion;Publishing;recruit;Reporting;response;Role;Sampling;self-renewal;Series;Shapes;Site;skeletal;skeletal disorder;skeletal stem cell;Solid Neoplasm;Source;Spinal Degenerative Disorder;Spinal Fusion;spine bone structure;standard of care;stem;stem cell biology;stem cell niche;stem cells;stemness;System;Therapeutic;transcription factor;Transplantation;tumor;vertebra body;Vertebral Bone;Vertebral column;Xenograft procedure

PROJECT_TITLE: Discovery of a stem cell governing vertebral physiology

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Group A Streptococcus is a top-10 cause of infectious mortality that through several toxins induces distinct cell death programs in different cells of it’s host. Cell death, and the resulting inflammation, contribute to poor patient outcomes during most diseases, including those caused by Streptococci. Understanding the specific molecular mechanisms of death gives therapeutic targets to improve the treatment of necrotizing fasciitis and other severe infections caused by Streptococcus, and tools to more broadly manipulate cell death during infections, aging, cancer, and autoimmune disease.

PI_NAMEs: LAROCK, CHRISTOPHER N (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Aging;Anatomy;Antibiotics;antimicrobial;Autoimmune Diseases;Autophagocytosis;Bacteria;Biological Response Modifiers;Cell Culture System;Cell Death;Cell Physiology;Cell Survival;Cells;Cellulitis;Cessation of life;Chemicals;Clinical;combat;Cues;Data;Disease;Disease Progression;DNA;Eating;Erysipelas;Excision;experimental study;extracellular;Failure;Foundations;Goals;Human;human pathogen;Immune;Immune Evasion;Immune response;Immunity;Immunologic Factors;Impetigo;improved;In Vitro;in vivo Model;Infection;Infectious Skin Diseases;Inflammation;Inflammatory;insight;Invaded;Investigation;keratinocyte;Licensing;Link;Lytic;Malignant Neoplasms;Measures;Mediating;Microbe;microbial;microbiota;Modeling;Molecular;mortality;Mus;mutant;Necrotizing fasciitis;neutrophil;Nuclear;Outcome;pathogen;Pathogenesis;pathogenic microbe;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;Penetration;Peptide Hydrolases;Pharyngeal structure;physical insult;Population;Predisposition;Process;programs;Protein Family;Proteins;Public Health;recruit;Reporter;Resistance;response;Rheumatic Heart Disease;Role;sensor;Serotyping;Signal Transduction;Site;Skin;spreading factor;Stimulus;Streptococcal Infections;Streptococcus;Streptococcus pyogenes;System;Testing;therapeutic target;therapeutically effective;three dimensional cell culture;Tissues;tool;Toxin;transmission process;Variant;Virulence;Virulence Factors;Work;wound healing

PROJECT_TITLE: GSDMA roles in skin innate immune defense

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE The proposed research seeks to evaluate changes in emergency room department utilization, hospitalizations, and uncompensated care among Latinx older adults in Illinois. Using hospital billing and Medicare cost data we leverage a novel natural experiment that expanded health insurance to immigrants previously excluded from health insurance. Our overarching goals is to understand structural inequalities that contribute to health disparities among aging Latinx adults and evaluate potential policy and practice interventions.

PI_NAMEs: MARTINEZ-CARDOSO, ARESHA MAREE (contact)

PROJECT_TERMS: Accident and Emergency department;Address;Adult;Age;Aging;allostatic load;American;baby boomer;Biological;Censuses;Characteristics;Chronic Disease;Clinical;cohort;Community Surveys;community-level factor;cost;County;Data;Documentation;Ethnic Population;Exclusion;experience;Goals;Health;Health and Retirement Study;Health Benefit;health care availability;Health Care Costs;health care disparity;health care service utilization;health determinants;health disparity;health inequalities;Health Insurance;Healthcare;High Prevalence;Hispanic Community Health Study;hospital care;Hospitalization;Hospitals;human old age (65+);Illinois;Immigrant;Immigration;indexing;Inequality;Insurance;Insurance Coverage;Interruption;Intervention;Latino;Latinx;Life Cycle Stages;Link;Low income;Medicaid;Medicare;Morbidity - disease rate;Natural experiment;novel;older adult;Older Population;Outcome;Patients;Policies;Population;Process;programs;public health insurance;Quasi-experiment;racial population;Research;Role;Scholarship;Series;Shapes;Signal Transduction;social health determinants;socioeconomics;Source;Stress;Time;Uncompensated Care;Uninsured

PROJECT_TITLE: Evaluating the roles of healthcare and community factors on healthcare disparities among aging immigrants


NIH_SPENDING_CATS: Cancer;Genetics;Prevention

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Protein kinases and lipid kinases have ATP pockets that are druggable and inhibitors of these two families of enzymes have been approved for treating cancers that have activating mutations in genes encoding these protein or lipid kinases. Yet, mass spec phosphoproteomics reveal that many cancers without obvious genetic aberrations in lipid or protein kinases have enhanced phosphorylation and activation of enzymes that drive anabolic processes. The focus of the proposed research is to utilize the software developed during the previous funding period (described above) to determine what protein kinases are likely to be driving growth of cancers based on changes in phosphorylation in the cancer compared to normal tissue and use this information to identify the appropriate protein kinase inhibitor to treat the cancer.

PI_NAMEs: CANTLEY, LEWIS C. (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Amino Acids;Automobile Driving;C-terminal;Cancer Control;cell growth;Cellular Metabolic Process;Computer software;Enzyme Activation;Enzymes;Event;Family;FRAP1 gene;Funding;Gene Family;Genes;Genetic;glucose uptake;Grant;Growth;Growth Factor;Human;IGF1 gene;inhibitor;inorganic phosphate;Insulin;Intervention;Length;Lipids;loss of function mutation;Malignant Neoplasms;Manuscripts;Mediating;Metabolism;mTOR protein;Mutation;N-terminal;Nature;neoplastic cell;Normal tissue morphology;Oncogenic;Oncogenic Viruses;Paper;Pharmacologic Substance;phosphatidylinositol 3-phosphate;Phosphatidylinositols;phosphoproteomics;Phosphorylation;Phosphotransferases;PIK3CA gene;PIK3CG gene;Positioning Attribute;prevent;Process;Production;Protein Dephosphorylation;Protein Kinase;protein kinase inhibitor;Proteins;Proto-Oncogene Proteins c-akt;PTEN gene;Publishing;Research;Role;Set protein;software development;Substrate Specificity;synthetic peptide;Tissues;tumor metabolism;Tumor Suppressor Genes;Work

PROJECT_TITLE: Role of Phosphoinositides and Protein Kinases in the control of Cancer Metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-E (M1)]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE In the study of regional variation and inequities in the U.S. health care system, too little attention has been paid to the measurement of health care and health “regions,” accounting for heterogeneity across regions, the lack of representation of the full population, and other forms of bias that could affect conclusions drawn from analyses based on Medicare data. Shortfalls include outdated measures based on data 30 years old (e.g., changes in hospital location and numbers), the failure of regions to capture rapidly changing health care markets (e.g., increasingly interwoven health care delivery in the U.S. due to health system mergers and the rise of specialist hospitals), and the inability to generalize to various sub-populations (especially historically and economically marginalized groups). This project seeks to address these concerns by utilizing the latest innovations in network and geospatial analyses to define new analysis areas for health care markets in the U.S. (and a user-friendly tool for forming them), allowing for heterogeneity across population strata and the construction of regional health disparity indices, and the development of statistical methods to account for sources of bias.

PI_NAMEs: O'MALLEY, ALISTAIR JAMES (contact)

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Accounting;Address;Affect;Age;algorithmic bias;Algorithms;Area;Area Analyses;Atlases;Attention;beneficiary;Caring;Catchment Area;Cessation of life;cohort;Communities;community engagement;comparative effectiveness;Comparative Effectiveness Research;conditioning;Containment;Data;data resource;demographics;Detection;Development;Disparity;empowerment;Equation;Ethnic Origin;Ethnic Population;Evaluation;Exclusion;experience;Failure;Fee-for-Service Plans;Future;geographic difference;Geographic Locations;Geography;Goals;Health;health care availability;Health Care Costs;health care delivery;health care disparity;health care model;health care service utilization;health disparity;health inequalities;Health Insurance;Health Policy;Health Professional;Health Status;Health system;Healthcare;Healthcare Market;Healthcare Systems;Heterogeneity;Hospital Referrals;Hospitalization;Hospitals;human old age (65+);improved;indexing;Inequity;innovation;Insurance;insurance claims;interest;Learning;Location;Managed Care;marginalized population;Marketing;Measurement;Measures;Medical;Medicare;Medicare claim;Methodology;Methods;migration;Modernization;neglect;Not Hispanic or Latino;novel strategies;Older Population;Outcome;Patients;Pattern;Patterns of Care;Persons;Physicians;Policies;Policy Maker;Population;practical application;Procedures;Provider;Public Health;Publishing;Quality of Care;Race;racial discrimination;racial disparity;racial population;Reporting;Research;Research Personnel;research study;Resources;Science;Selection Bias;sex;sex disparity;Source;Specialist;Specific qualifier value;Standardization;Statistical Methods;Structural Racism;Survivors;Testing;Time;tool;treatment pattern;Underserved Population;Update;user-friendly;Variant;Visit

PROJECT_TITLE: Geographic Variations in Health Care: Overcoming Bias, Expanding Generalizability, and Improving Relevance

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PITTSBURGH

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: In patients affected by periodontitis, after controlling the disease, periodontists and general dentists need to perform regenerative procedures to re-establish the normal anatomy and function of the periodontium. However current regenerative therapies are ineffective as they are unable to fully regenerate the missing periodontal tissues. With the final goal of developing more effective periodontal regenerative therapies, this research proposal aims at characterizing the periodontal stem cells and at identifying strategies to harness them to endogenously sustain periodontal regeneration.

PI_NAMEs: INTINI, GIUSEPPE  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Affect;Anatomy;AXIN2 gene;Biocompatible Materials;Biological;bone;Bone Regeneration;c-myc Genes;Calvaria;Cardiovascular Diseases;Cell surface;Cells;Complex;Connective Tissue;craniofacial development;Data;Defect;Dental Cementum;Dentists;Development;Diabetes Mellitus;Disease;disorder control;Down-Regulation;Economic Burden;Ectopic Expression;effective therapy;Fostering;Genes;GLI gene;Goals;Health;High Prevalence;Homologous Gene;Human;In Vitro;in vivo;Incisor;induced pluripotent stem cell;ineffective therapies;inhibitor;Investigation;ITGA7 gene;Knowledge;Limb Development;Link;long bone;Lung infections;Molecular;Molecular Profiling;mouse model;Mus;Natural regeneration;novel;novel therapeutics;Oral mucous membrane structure;Osteogenesis;osteogenic;Patients;Periodontal Diseases;Periodontal Ligament;Periodontitis;Periodontium;Persons;Phenotype;Population;postnatal;Procedures;Proliferating;Protocols documentation;Public Health;regeneration potential;regenerative;regenerative therapy;regenerative tissue;Research Personnel;Research Project Grants;Research Proposals;Signal Transduction;single-cell RNA sequencing;six transmembrane epithelial antigen of the prostate 4;skeletal stem cell;Sorting;stem cell expansion;stem cells;Surface;Teratoma;Testing;Therapeutic;Tissues;tool;Tooth Loss;transcription factor;Transplantation;WNT Signaling Pathway

PROJECT_TITLE: Harnessing PRX1 expressing cells for endogenous periodontal regeneration

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Diabetes;Digestive Diseases;Endocrine Disruptors;Health Effects of Indoor Air Pollution;Liver Disease;Nutrition;Obesity

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative: Over 90% of Americans are exposed to the flame-retardant chemical tris(1,3-dichloro-2- propyl) phosphate (TDCPP). TDCPP exposure is positively associated with metabolic syndrome in men, but women are protected from its harmful effects. The proposed studies interrogate the role of nuclear receptors and sex hormones in conferring sex-specific metabolic disruption associated with TDCPP exposure, which will drive our knowledge toward interventions and screening strategies for less harmful flame retardants.

PI_NAMEs: RASHID, CETEWAYO SAIF (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Adipose tissue;Adverse effects;Agonist;American;Androgen Receptor;blood glucose regulation;Body Composition;Body fat;C57BL/6 Mouse;Chemicals;clinical translation;consumer product;Consumption;Data;Development;Diet;dietary;differential expression;Dose;Dust;Endocrine Disruptors;Environment;Environmental Exposure;Environmental Pollutants;Epidemiology;Estrogen Receptors;Evaluation;Event;experimental study;exposed human population;exposure route;Exposure to;fasting plasma glucose;Fatty acid glycerol esters;Fatty Liver;Female;Flame Retardants;follow-up;Frequencies;Future;Genes;Glucose Clamp;glucose production;glucose tolerance;glucose uptake;Gonadal Steroid Hormones;Hand;Hepatic;Human;human female;Hyperglycemia;Hyperinsulinism;Impairment;improved;In Vitro;Industrialization;inorganic phosphate;Insulin;Insulin Resistance;insulin signaling;Intervention;Knowledge;lipid biosynthesis;Liver;liver inflammation;male;Male Castration;Mediating;men;Metabolic;Metabolic dysfunction;Metabolic syndrome;Metabolism;Modeling;mouse model;mRNA sequencing;Mus;Muscle;National Health and Nutrition Examination Survey;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear Receptors;Obesity;off-gassing;Oral cavity;Orchiectomy;Organophosphates;Overnutrition;Pathway interactions;Peripheral;Phosphorylation;Physiological;Phytoestrogens;poor health outcome;Pre-Clinical Model;preclinical study;pregnane X receptor;receptor;Receptor Activation;Receptor Gene;Research;response;RNA Sequences;Rodent;Role;Route;Saline;screening;sex;Sex Differences;Signal Transduction;skeletal tissue;stable isotope;sugar;Suggestion;Testing;Tracer;Transactivation;transcriptome;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;urinary;Urine;Wild Type Mouse;Woman;Xenobiotics

PROJECT_TITLE: Mechanisms of Sex-specific Metabolic Disruption Caused by Organophosphate Flame Retardant Exposure

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Tuberculosis (TB) is the leading cause of death from an infectious pathogen, and more advanced strategies are needed to curb the global epidemic. We aim to develop an innovative, low cost, efficacious protein and adjuvant vaccine candidate for therapeutic protection given in conjunction with drug treatment against Mycobacterium tuberculosis. We expect our findings will lead to understanding key protective immune correlates in the context of therapy, which will also positively impact TB patients and those striving to cure TB.

PI_NAMEs: BALDWIN, SUSAN LOUISE;COLER, RHEA N (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Acute;adaptive immune response;Adjuvant;Animal Model;Antigens;Bacterial Counts;Bar Codes;Biological Sciences;C57BL/6 Mouse;candidate selection;Cause of Death;Cavia;Cells;chemotherapy;Clinical;Clinical Trials;Combined Vaccines;Communicable Diseases;Complement;Consensus;cost;design;Development;Disease;disorder prevention;Dose;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;Ensure;Epidemic;Evaluation;Genetic;Genotype;Goals;guinea pig model;Human;Immune;Immune response;Immunity;Immunization;Immunologic Memory;Immunologics;Immunotherapeutic agent;In Vitro;in vitro activity;in vivo;Individual;Infection;innovation;Intellectual Property;Intramuscular;Knowledge;Lead;lead candidate;Lung;Lung infections;Measures;Methods;Modeling;Montana;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Mus;Mycobacterium tuberculosis;novel;Outcome;pathogen;Patients;Pharmacotherapy;Population;pre-clinical;Pre-Clinical Model;preclinical efficacy;preclinical study;prevent;Prevention;Prevention approach;Primary Infection;Primary Prevention;Property Rights;Proteins;Pulmonary Pathology;Relapse;Research;research clinical testing;response;RNA;Route;Safety;screening;secondary infection;Series;sex;Signal Transduction;Spleen;success;System;Therapeutic;therapeutic candidate;therapeutic vaccine;therapeutically effective;TLR4 gene;Treatment Efficacy;Treatment Protocols;Tuberculosis;Tuberculosis Vaccines;Universities;Vaccination;vaccine candidate;vaccine immunogenicity;Vaccine Therapy;Vaccines;Weight

PROJECT_TITLE: Immunotherapeutic approach for the prevention of secondary infection with drug-resistant TB


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Telehealth

ORG_CITY: NEW HAVEN

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Patients and healthcare providers are increasingly using the patients' portal messaging system for communication. In this study, we propose to extract different types of electronic patient-provider communication (EPPC) in the portal such as information seeking/giving and shared decision making using an innovative natural language processing and machine learning based tool called EPPCminer. We will characterize the distribution of EPPC types in messages and assess the impact of EPPC types on patients' outcomes including adherence, emergency visits and hospitalizations.

PI_NAMEs: JARAD, SAMAH JAMAL FODEH (contact)

PROGRAM_OFFICER_NAME: VANDERPOOL, ROBIN CLINE

PROJECT_TERMS: Address;Adherence;adherence rate;Adverse drug event;Breast;Cancer Patient;cancer therapy;Categories;chemotherapy;Clinic;Clinical;Clinical Management;Code;cohort;Colorectal;Communication;cost;Data;Diagnosis;digital data;digital health;Disseminated Malignant Neoplasm;Economics;Electronics;Emergency department visit;Emergency medical service;Emergency Situation;Emotional;emotional behavior;Empathy;Ensure;follow-up;Food;Frequencies;Future;Goals;Health Personnel;Health system;Hospitalization;Image;improved;improved outcome;innovation;Knowledge;Language;Linguistics;Lung;Machine Learning;Malignant Neoplasms;Manuals;Maps;Measures;Medical;Melanoma;Methods;Modeling;Natural Language Processing;Oral;Outcome;Patient Compliance;patient oriented;patient portal;patient-clinician communication;Patient-Focused Outcomes;Patients;Pattern;personalized health care;Persons;Pharmaceutical Preparations;Pharmacy facility;Population Distributions;prospective;Prostate;Provider;provider communication;Reporting;response;Roter;Sampling;Secure;service utilization;Services;shared decision making;skills;social health determinants;Subcategory;System;Systems Analysis;Telecommunications;tool;Transportation;Trust;United States Department of Veterans Affairs;Variant;Visit;Work

PROJECT_TITLE: Quantifying patient-provider communication using machine learning to assess its impact on metastatic cancer patients' outcomes

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Disability Research;Genetics;Mental Health;Nutrition;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE In this proposal, our overall goal is to examine how two biological processes involved in aging and age-related conditions, cellular senescence and epigenetic alterations, influence adaptations to exercise training in older adults. We will conduct a randomized controlled clinical trial comparing the effects of 6-months of strength training to a health education program on measures of physical function and whole-body metabolism in persons 65 years of age and older. Using risk modeling approaches, we examine how the biological processes, clinical variables (e.g., sex, chronic conditions, medications), and behaviors (e.g., nutrition and sleep), and their interactions, influence changes in these clinically important outcomes in study participants.

PI_NAMEs: FIELDING, ROGER A.;LEBRASSEUR, NATHAN K (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Affect;age related;age related changes;aging mechanism;aging related;Behavior;Behavioral;Biological;Biological Process;blood lipid;blood-based biomarker;Body mass index;Cardiovascular Diseases;Cell Aging;Cells;Chronic;Chronic Disease;circulating biomarkers;Clinical;clinical research site;Clinical Trials;Communities;comorbidity;Data;depressive symptoms;disability;DNA Methylation;Educational Intervention;Elderly;Epigenetic Process;Exercise;exercise training;Exhibits;Fatigue;Foundations;frailty;functional adaptation;Gene Expression;Genetic Transcription;Glucose;Goals;Guidelines;Health education;Health Promotion;Heterogeneity;Homeostasis;Human;human old age (65+);Hypermethylation;Impaired cognition;Impairment;improved;Individual;innovation;Insulin;insulin secretion;insulin sensitivity;interdisciplinary approach;International;intervention participants;late life;Malignant Neoplasms;Measures;Mediating;men;Mental Depression;Metabolic;Metabolism;Mobility disability;Modeling;Modification;Molecular Profiling;morphogens;Muscle;muscle strength;Natural regeneration;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional status;older adult;older women;Outcome;Outcome Measure;Participant;Pathology;Persons;Pharmaceutical Preparations;Physical activity;Physical Function;Physical Performance;Physiological;Physiological Adaptation;primary outcome;Probability;programs;Randomized;Randomized Controlled Clinical Trials;resistance exercise;response;Risk;secondary outcome;senescence;senescence associated secretory phenotype;senescent cell;sex;Site;Skeletal Muscle;Sleep;Stimulus;strength training;Structure;Syndrome;Testing;Tissues;Training and Education;treatment effect;trial comparing;Waist-Hip Ratio;Walking;Whole Blood;Woman

PROJECT_TITLE: The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults (BRIO)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-A (M1)]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Multiple protein fragments called peptides will be arranged in a single biochemical structure to bind to targets expressed uniquely on the surface of liver cancer cells. This contrast agent will be labeled for use with magnetic resonance and laparoscopic imaging for early detection of liver cancer.

PI_NAMEs: WANG, THOMAS D (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Address;Antibodies;Benign;Binding;Biochemical;Biodistribution;Biological Markers;Blood Vessels;cancer cell;CD44 gene;Cell Separation;Cell surface;cell transformation;Cells;Clinical;clinically relevant;Contrast Media;cost;Detection;Development;Diagnostic;Diffuse;Dimensions;Early Diagnosis;Effectiveness;Epitopes;Event;Extravasation;fluorescence imaging;Genetic;GPC3 gene;Hepatocyte;Heterogeneity;human disease;Image;imaging biomarker;immunogenicity;Implant;implantation;improved;in vivo;in vivo imaging;Incidence;Individual;interstitial;Label;Laparoscopy;large scale production;Lead;Length;Lesion;Ligands;Liver;liver cancer model;Location;Magnetic Resonance;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;Methodology;Methods;Modeling;Molecular;Molecular Target;Molecular Weight;monomer;neoplastic cell;novel;optical imaging;Organ;Pathogenesis;patient derived xenograft model;patient population;Patients;Penetration;Peptide Synthesis;Peptides;Performance;Phage Display;Population;pre-clinical;Pre-Clinical Model;Primary carcinoma of the liver cells;Process;Property;Protein Fragment;Proteins;receptor binding;Reproducibility of Results;response;scale up;Screening for cancer;Screening for Hepatocellular Cancer;serological marker;single-cell RNA sequencing;Solid;Solid Neoplasm;specific biomarkers;Specificity;Specimen;Structure;subcutaneous;success;Surface;TACSTD1 gene;Therapeutic;Time;Tissues;transcriptomics;tumor;Tumor Burden;tumor microenvironment;Tumor stage;uptake;α-Fetoproteins

PROJECT_TITLE: Peptide multimer for early detection of hepatocellular carcinoma

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ORG_DEPT: UROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: EZH2 is a well-known histone lysine methyltransferase and an oncogene upregulated in many types of cancer, including prostate cancer. In this project, we will investigate how EZH2 methylates its novel substrate PARP1, and how EZH2-mediated PARP1 methylation in prostate cancer. In addition, we will study how EZH2 plays its role in PARP inhibition-resistant prostate cancer. Successful completion of this project will provide novel mechanistic insights EZH2’s novel functions in DNA damage repair and transcription regulation.

PI_NAMEs: CAO, QI  (contact);NIU, HENGYAO

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Address;Adult;advanced prostate cancer;Affect;Affinity;American;Attention;Binding;Biological;Biological Markers;BMI1 gene;Cancer Etiology;cancer initiation;Cancer Patient;cancer type;Cell Maintenance;Cells;Cessation of life;Chromatin;Chromosomal Instability;Clinical;cofactor;combinatorial;Complex;Core Protein;Data;Defect;design;Development;Diagnosis;DNA;DNA Damage;DNA Repair;Drug resistance;Early Diagnosis;Early treatment;effective therapy;Enhancers;Epigenetic Process;Epithelioid Sarcomas;Follicular Lymphoma;Future;gain of function;gain of function mutation;GATA4 gene;Gene Expression;gene repression;Gene Silencing;Genetic Transcription;genomic locus;Growth;Histone H3;histone methylation;histone methyltransferase;Histone-Lysine N-Methyltransferase;Homologous Gene;homologous recombination deficiency;inhibitor;insight;Lysine;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mediating;men;metabolomics;Metastatic Prostate Cancer;Methylation;Modification;Mus;Neoplasm Metastasis;novel;Oncogenes;Oncogenic;Outcome;overexpression;patient subsets;Patients;Pharmaceutical Preparations;pharmacologic;Play;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Polycomb;prostate cancer cell;prostate cancer model;prostate cancer progression;Prostate Cancer therapy;Prostate carcinoma;protein H(3);Proteins;recruit;refractory cancer;Regulation;Reporting;Repression;Resistance;Resistance development;response;Role;side effect;STAT3 gene;stem cells;Testing;Therapeutic;therapeutic target;therapeutically effective;therapy resistant;Transcript;Transcriptional Regulation;Treatment Efficacy;tumor;tumor progression;tumor xenograft;United States;Work;Xenograft procedure

PROJECT_TITLE: A novel role for EZH2 in PARP regulation and PARPi-resistance in prostate cancer

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Our group has developed a novel antibody capture slide array approach to profile N-glycans of captured glycoproteins. To translate this finding we will establish an inter-disciplinary, multi-institutional research team, working in strategic alliance with both industry and clinical partners to validate our identified biomarker.

PI_NAMEs: MEHTA, ANAND S. (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Acceleration;Acute Disease;Address;AFP gene;Algorithms;Antibodies;Basic Science;Biological Assay;Biological Markers;biomarker development;biomarker identification;biomarker panel;Blinded;cancer type;case control;Case/Control Studies;Chemistry;Chronic Disease;Cirrhosis;Clinical;Clinical Investigator;clinical practice;Consumption;Data;Detection;Development;Diagnosis;Diagnostic;diagnostic algorithm;Discrimination;Disease Management;Engineering;Ensure;Funding Opportunities;Glycoproteins;glycosylation;Goals;improved;Individual;Industrialization;Industry;industry partner;Institution;instrument;Knowledge;Laboratories;Legal patent;Licensing;Link;Liver diseases;machine learning algorithm;MALDI-TOF Mass Spectrometry;Malignant - descriptor;Malignant Neoplasms;mass spectrometric imaging;Measurement;Measures;Medical;Medical center;Methodology;Methods;Modification;multidisciplinary;new technology;novel;Patients;Peptide N-glycohydrolase F;Phase;Polysaccharides;pre-clinical;premalignant;prevent;Primary carcinoma of the liver cells;protein purification;Publications;Quality Control;Reproducibility;Research;Research Methodology;Risk Assessment;Sampling;Serum;Sialic Acids;Slide;South Carolina;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;sugar;Technology;Testing;Texas;Time;Tissues;tool;Translating;Translations;tumor;Universities;Validation

PROJECT_TITLE: Translating glycans into biomarkers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-E (57)]


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative The proposed research is relevant to public health, because there is an unmet need for more effective treatment of non-small cell lung cancer (NSCLC), and our proposed research is focused on evaluating a new agent, a recombinant human protein known as PEPDG278D, for its therapeutic activity in preclinical models of NSCLC by potentially targeting the key vulnerability of therapy-resistant NSCLC cells. Given that PEPDG278D has not shown toxicity in previous animal studies, promising results from the proposed research may lay the groundwork for potential clinical development of this agent for treating NSCLC. Therefore, the proposed research is relevant to the part of NCI’s mission that pertains to accelerating scientific discovery to reduce the burden of cancer and suffering of cancer patients.

PI_NAMEs: ZHANG, YUESHENG  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Acceleration;Address;Animals;Asia;Binding;Cancer Burden;cancer cell;Cancer cell line;Cancer Patient;Cell surface;Cisplatin;Clinical;clinical development;clinically relevant;Collagen;Complement;Complex;Disease;Drug resistance;effective therapy;EGFR Protein Overexpression;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Epithelium;ERBB2 gene;Europe;Extracellular Domain;gemcitabine;Generations;Heterodimerization;Human;IGF1R gene;KRAS2 gene;lung cancer cell;Malignant Breast Neoplasm;Malignant neoplasm of lung;Mediating;Mesenchymal;Metabolism;Mission;Molecular;Monoclonal Antibodies;monomer;mutant;Mutate;Mutation;New Agents;Non-Small-Cell Lung Carcinoma;Normal Cell;novel;Oncogenic;Outcome;overexpression;Patients;Pharmaceutical Preparations;Phosphotransferases;PIK3CA gene;Pre-Clinical Model;Predisposition;Protein Tyrosine Kinase;Proteins;Public Health;receptor function;Receptor Protein-Tyrosine Kinases;Recombinants;Research;research clinical testing;Resistance;resistance mechanism;Signal Transduction;small cell lung carcinoma;targeted agent;Testing;Therapeutic;therapeutic target;therapy outcome;therapy resistant;Toxic effect;Translating;tumor;Tyrosine Kinase Domain;Work;Xaa-Pro dipeptidase

PROJECT_TITLE: Targeted Degradation of EGFR and HER2 in NSCLC

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: WILLS EYE HEALTH SYSTEM

PHR: Project Narrative This research proposal focuses on the development and refinement of innovative image processing and analytical methods that will substantially improve detection of glaucoma and the identification and prediction of its progression in order to prevent blindness. We will develop technology to improve optical coherence tomography (OCT) signal and image quality and harmonize OCTs such that it is possible to be agnostic as to device manufacturer or model. Finally, we will use recently developed analytical techniques including multidimensional information compression analysis (MICA) and enhanced machine learning and deep learning models incorporating clinical features in addition to OCT and visual fields to significantly improve glaucoma detection and the identification of progression and prediction of future disease progression.

PI_NAMEs: SCHUMAN, JOEL S (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: advanced disease;Algorithms;analytical method;Artificial Intelligence;Blindness;Cells;Characteristics;Clinical;Clinical Management;clinical practice;Clinical Research;cohort;Computer software;Data;data harmonization;Data Set;deep learning;deep learning model;denoising;Detection;Development;Devices;Diagnosis;Diagnostic;Diffusion;Dimensions;Discrimination;Disease;Disease Progression;Early Diagnosis;Early identification;Evaluation;Eye;Future;Glaucoma;Health Care Costs;Image;Image Analysis;Image Compression;image processing;imaging biomarker;Imaging technology;improved;innovation;insight;instrument;invention;Laboratories;Machine Learning;machine learning method;machine learning model;Manufacturer;Measurable;Measurement;Methods;Microscopy;Modeling;Monitor;Morbidity - disease rate;Nature;novel;ocular imaging;Optical Coherence Tomography;Outcome;Patient Care;Patients;Performance;personalized medicine;predictive modeling;preservation;prevent;programs;Research;Research Proposals;Risk Factors;Sampling;Scanning;Severity of illness;signal processing;Signal Transduction;Structure;superresolution imaging;supervised learning;support vector machine;Techniques;Technology;Testing;Three-Dimensional Image;Tissues;tool;Translating;Vision;Visual;Visual Fields;Visualization

PROJECT_TITLE: Novel Glaucoma Diagnostics for Structure and Function.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Lymphatic Research;Lymphedema;Nanotechnology;Prevention;Regenerative Medicine;Women's Health Research

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

ORG_STATE: CA

PHR: NARRATIVE Lymphedema affects approximately 200 million patients globally and is associated with regional accumulation of lymph fluid due to obstructions to the lymphatic vessels, accompanied by compromise of local immune function and, ultimately, irreversible structural changes of the affected tissues. To bridge the region of lymphatic obstruction, we propose the implantation of nanofibrillar collagen conduits for driving capillary flow and promoting lymphatic regeneration. These proposed studies aim to develop a novel biomaterials-based therapeutic strategy and then to test its therapeutic efficacy in rodent models of lymphedema.

PI_NAMEs: HUANG, NGAN F. (contact);PAUKSHTO, MICHAEL VITOLDOVICH

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Academia;Acceleration;Address;Affect;Animal Model;associated symptom;Automobile Driving;Axilla;Axillary Lymph Node Dissection;Biocompatible Materials;Biomedical Engineering;biophysical properties;Blood;Blood capillaries;Breast Cancer survivor;Bypass;Cancer Intervention;Cancer Patient;cancer surgery;cancer therapy;Capillarity;Cell Physiology;chemical property;Chronic;Chronic Disease;Clinical;Clinical Research;clinical translation;clinically relevant;Collaborations;Collagen;Control Groups;Country;Data;Deep Vein Thrombosis;density;Development;Devices;Diameter;Disease;Doctor of Philosophy;Drainage procedure;Edema;Engineering;Excision;Extracellular Matrix;Fibrillar Collagen;Formulation;Generations;healing;Healthcare;high risk;high risk population;Histologic;Human;Image;immune function;Implant;implantation;improved;In Vitro;in vivo;Incidence;Indocyanine Green;Industry;Intercellular Fluid;interest;Intervention;irradiation;Length of Stay;Liquid substance;Lymph;lymph flow;lymph nodes;Lymphangiogenesis;Lymphatic;Lymphatic Endothelial Cells;Lymphatic Obstruction;Lymphatic System;lymphatic vessel;Lymphedema;macromolecule;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Measures;mechanical properties;microCT;Microsurgery;Modeling;mouse model;Mus;nanofibrillar;nanoscale;Nanostructures;Natural regeneration;novel;Obstruction;Operative Surgical Procedures;Outcome;Output;Patients;Pattern;Perfusion;Phenotype;Physical therapy;pre-clinical;preclinical study;Prevention;Preventive;preventive intervention;Preventive treatment;Progressive Disease;Property;psychosocial;Rattus;reduce symptoms;Reporting;Risk;Rodent Model;secondary lymphedema;Secondary Prevention;soft tissue;Structure;Swelling;Symptoms;Tail;Technology;Testing;Therapeutic;therapeutic evaluation;Time;Tissues;Translating;translational applications;Translational Research;Treatment Efficacy;treatment group;treatment strategy;Universities;Veins;Visualization

PROJECT_TITLE: Development of a Bioengineered Therapeutic Device for the Prevention of Lymphedema


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Lymphatic Research;Neurodegenerative;Neurosciences;Pancreatic Cancer;Peripheral Neuropathy;Rare Diseases

PHR: Narrative Pancreas cancer is the third leading cause of cancer death in the United States. Recent evidence suggest that the aggressive nature of pancreas cancer is related to interactions between pancreatic nerves and immune cells. In this proposal we will determine how nerve-immune interactions contribute to pancreas cancer and whether targeting nerves can be an effective adjuvant therapy.

PI_NAMEs: SALOMAN, JAMI LYNN (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: 3-Dimensional;Ablation;Adjuvant Therapy;afferent nerve;Afferent Neurons;Allografting;anti-PD-1;anti-PD-L1 therapy;Binding Proteins;Biological Assay;Brain-Derived Neurotrophic Factor;Cancer Etiology;Cancer Model;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Cessation of life;checkpoint therapy;Chemicals;chemotherapy;Combination Drug Therapy;cytotoxicity;Data;Denervation;Development;Disease;Drainage procedure;draining lymph node;efficacy evaluation;Enzyme-Linked Immunosorbent Assay;Exclusion;Exhibits;experimental study;gemcitabine;glial cell-line derived neurotrophic factor;Human;Hypertrophy;Immune;immune checkpoint;Immune response;Immune signaling;Immunologist;Immunosuppression;Immunosuppressive Agents;improved;improved outcome;Induced Neurons;interest;Intervention;Invaded;Leucocytic infiltrate;lymph nodes;Lymphocyte Count;lymphoid structures;Malignant - descriptor;Malignant Lymph Node Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Manipulative Therapies;Membrane;Modeling;mouse model;Mus;Nature;Neoplasm Metastasis;Nerve;Nerve Fibers;nerve supply;Nervous System;neural;Neuroimmune;Neurons;neurotrophic factor;novel;NRP1 gene;Pancreas;Pancreatic Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathway interactions;Patient Care;Patients;PD-1/PD-L1;perineural;Peripheral;Peripheral Nerves;Phenotype;Population;pre-clinical;premalignant;Prognosis;Prognostic Marker;programmed cell death ligand 1;Proliferating;Property;Proteins;Refractory;Regulation;Regulatory T-Lymphocyte;Resected;RNA;Role;Sensory;Signal Transduction;Site;Specimen;Structure;success;System;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Tissues;Transcript;Transgenic Mice;Treatment Efficacy;tumor;Tumor Cell Invasion;tumor growth;tumor microenvironment;tumor progression;Tumor-Derived;Tumor-Infiltrating Lymphocytes;tumorigenesis;tumorigenic;United States;Work

PROJECT_TITLE: Peripheral Nerve Regulation of Pancreas Cancer Progression

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Aging;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The SoCal UDN will serve as a regional Diagnostic Center of Excellence within the national UDN and will offer in-depth expert clinical and research evaluation to improve the diagnosis and care for patients with undiagnosed diseases. We will partner with regional referral centers as well as community programs to expand access to UDN expertise to patients throughout the southwestern US with an emphasis on medically underserved populations. This program will advance our understanding of rare disease pathogenesis and improve the diagnostic process.

PI_NAMEs: ABDENUR, JOSE ;CHAO, ELIZABETH CAROL;LA SPADA, ALBERT R;VILAIN, ERIC J. (contact);XIAO, CHANGRUI

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: age group;American;Area;Biochemical;Biochemical Genetics;Biological;biomedical referral center;California;care coordination;Caring;chatbot;Child;Clinical;clinical care;Clinical Data;clinical infrastructure;clinical phenotype;Clinical Research;clinical research site;Clinical Sciences;Collaborations;Communities;Community Health;Community Hospitals;community partners;cost;County;Data;data management;Data Science;data sharing;design;Diagnosis;Diagnostic;Diagnostic Services;Disclosure;Disease;economic disparity;Economically Deprived Population;Enrollment;Environment;Equity;Evaluation;Evaluation Research;exome sequencing;Foundations;Future;Genetic;Genetic Medicine;Genome;genomic data;Genomic medicine;genomic variation;Genomics;Genotype;Improve Access;improved;Informed Consent;Infrastructure;Institution;Intervention;Laboratories;Left;Machine Learning;Maintenance;Maps;Medical;Medical center;Medical Records;medically underserved population;Modeling;non-genetic;operation;Optics;Oranges;Pathogenesis;Patient Care;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Phenotype;phenotypic data;Physicians;Privatization;Process;programs;Protocols documentation;psychologic;Quality of life;Rare Diseases;Recording of previous events;Research;Research Activity;research clinical testing;Research Infrastructure;Research Personnel;research study;Resources;Sampling;Services;Site;Southwestern United States;Standardization;Technology;Testing;tool;transcriptome sequencing;Translational Research;Travel;Underserved Population;Update;Vietnamese;Work

PROJECT_TITLE: Southern California Undiagnosed Disease Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (21)]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Microbiome;Natural Products;Rheumatoid Arthritis

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Despite strong associative evidence of a gut-joint axis driving inflammatory arthritis such as rheumatoid arthritis (RA) and spondyloarthritis (SpA), the specific mechanisms by which microbes or their products trigger intestinal immune dysregulation in the context of inflammatory arthritis have not been elucidated. The goal of this project is to define one pathway – tryptophan catabolism to indole – by which bacterial dysbiosis of RA and SpA contribute to pathogenic T and B cell responses relevant to disease.

PI_NAMEs: KUHN, KRISTINE A. (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Address;Ankylosing spondylitis;Antibiotics;Arthritis;Aryl Hydrocarbon Receptor;Autoantibodies;Autoimmunity;Automobile Driving;B-Lymphocytes;Bacteria;bacterial metabolism;Catabolism;Cell Differentiation process;Cell Physiology;Cells;cellular targeting;Clinical;cohort;Collagen Arthritis;Crohn's disease;cytokine;Data;Dendritic Cells;Development;Diet;Disease;dysbiosis;Enzymes;Feces;Funding;Gene Expression Profile;Generations;Genes;glycosylation;Goals;gut bacteria;Harvest;host-microbe interactions;Human;IL17 gene;Immune;immune function;Immune response;Immunity;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;Immunologics;In Vitro;in vivo;Individual;Indoles;Inflammatory Arthritis;interleukin-21;interleukin-23;Intestinal Mucosa;Intestines;Investigation;ITGAM gene;joint inflammation;Joints;Knowledge;Link;mesenteric lymph node;Metabolism;metabolomics;Metagenomics;Microbe;microbial;microbiome;Modeling;Modification;Molecular Biology Techniques;monocyte;Mononuclear;mouse model;Mus;novel;pathogenic autoantibodies;Pathogenicity;Pathway interactions;Patients;Pattern;Phagocytes;Pharmaceutical Preparations;Plasma;Population;pre-clinical;Production;receptor;Research;response;Rheumatoid Arthritis;Risk;Sampling;screening;Signal Pathway;Signal Transduction;single cell ATAC-seq;Spondylarthritis;Supplementation;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Tissues;transcriptome sequencing;Translating;Tryptophan;Tryptophan Metabolism Pathway;Work

PROJECT_TITLE: Influence of bacterial tryptophan metabolism on inflammatory arthritis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunotherapy;Nanotechnology;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative Our team has created a plant virus nanotechnology that, when injected into tumors, alters the tumor environment to boost immune responses against the tumor - this method has shown effectiveness in mouse tumor models and canine cancer patients. However, challenges like large tumors needing multiple injections and high fluid pressure in tumors can limit its success. This grant aims to design slow-release polymer blends as injectables, to simplify the procedure and reduce repeat doses. Effectiveness will be evaluated in mice and dogs.

PI_NAMEs: POKORSKI, JONATHAN KYLE;STEINMETZ, NICOLE FRANZISKA (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: 4T1;Affect;Antitumor Response;Avidity;biodegradable polymer;Biological;Biological Products;Blood Vessels;breast cancer metastasis;cancer immunotherapy;Cancer Patient;cancer recurrence;Canis familiaris;CD8B1 gene;cell growth;Cell Physiology;Cells;Clinical Trials;Collaborations;companion animal;Cowpea Mosaic Viruses;Data;Dendritic Cells;design;Development;Devices;Disease;Dose;Drug Delivery Systems;Drug Industry;Effectiveness;efficacy evaluation;Emulsions;Environment;Equipment;ERBB2 gene;Estrogen receptor positive;Event;Face;Foreign-Body Reaction;Formulation;Future;Glycolates;Grant;Histopathology;Immune;Immune response;Immune system;Immunocompetent;Immunologic Memory;Immunosuppression;Immunotherapy;Implant;Industrialization;Infiltration;Injectable;Injections;insight;International;Liquid substance;Love;Macrophage;Malignant Breast Neoplasm;Mammary Neoplasms;manufacturing technology;melting;Metastatic breast cancer;Methods;Modeling;Molds;Molecular;Mouse Mammary Tumor Virus;mouse model;Mus;nanoparticle;Nanotechnology;Natural Killer Cells;Nature;neoantigens;neutrophil;Nonmetastatic;novel;Nucleoproteins;Outcome;particle;pathogen;patient population;Patient Recruitments;Patients;Pattern;Pharmaceutical Preparations;Phase;Phenotype;Plant Viruses;Plasticizers;Polyethylene Glycols;Polymers;polyoma middle tumor antigen;predictive marker;pressure;prevent;Procedures;Process;Prognostic Marker;Proteins;Recurrence;Research;research clinical testing;Resources;Safety;Site;Solid Neoplasm;Solvents;Spain;success;T memory cell;Technology;Temperature;Testing;Toll-like receptors;Transgenic Mice;Translating;Translational Research;Translations;trial enrollment;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Universities;Veterinary Schools;Weight;willingness

PROJECT_TITLE: CPMV-Polymer Devices to Enhance the Outcomes of Intratumoral Immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-U (55)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Mobile computed tomography (CT) is widely used in the neuro intensive care units (ICU) to reduce the risk during the transportation of critically ill patients to a fixed CT scanner. However, it suffers from deteriorated image quality compared to a fixed scanner and is insufficient for the diagnosis of small lesions. In this project, we propose to leverage the benefits from a photon-counting mobile CT, as well as deep learning-based image reconstruction algorithms, to improve the image quality of mobile CT to or beyond the level of a fixed CT scanner.

PI_NAMEs: GUPTA, RAJIV ;WU, DUFAN  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Adverse effects;Adverse event;Affect;Alberta province;Algorithms;Area;bone;Brain;Brain imaging;calcification;Calcium;Caring;Clinical;Computed Tomography Scanners;cranium;Critical Illness;Data;deep learning;deep learning algorithm;deep neural network;Deterioration;Diagnosis;Diagnostic;diagnostic accuracy;Discrimination;Dose;effectiveness evaluation;Extravasation;FDA approved;Goals;Hemorrhage;Image;Image Analysis;Image Enhancement;image reconstruction;imaging capabilities;Implant;improved;Infarction;Inferior;insight;Intracranial Hemorrhages;Iodine;Lesion;Manufacturer;metallicity;Metals;Methods;mobile computing;Monte Carlo Method;Morbidity - disease rate;Morphologic artifacts;Motion;Myelin;Noise;Patient Care;Patients;Photons;Posterior Fossa;Predisposition;prevent;Process;programs;Qualitative Evaluations;Quality of Care;radiologist;Reader;reconstruction;Resolution;Resource-limited setting;Risk;Risk Reduction;routine imaging;routine practice;self supervised learning;simulation environment;soft tissue;spectrograph;Stains;Stroke;Structure;Subarachnoid Hemorrhage;supervised learning;Techniques;Testing;Training;transfer learning;Transportation;Vendor;virtual;white matter;X-Ray Computed Tomography

PROJECT_TITLE: Optimizing Mobile Photon-Counting CT Image Quality via Deep Learning for Neuro Intensive Care Unit

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]