NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: MORRIS, JOHN  (contact)

PROJECT_TERMS: Address;Adult;African American;African American population;Age;aging brain;Aliquot;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid beta-42;Area;Autopsy;Behavioral;Biological Assay;Biological Markers;Blood;Brain;brain magnetic resonance imaging;Caring;Circadian Rhythms;Clinical;Clinical assessments;Cognitive;cognitive function;cognitive testing;cohort;Communities;Data;data exchange;data management;Data Set;Dementia;Dermal;Development;Disease;DNA;education research;Eligibility Determination;Enrollment;Ensure;Etiology;Fibroblasts;Funding;Genetic;Glycosylated hemoglobin A;Grant;Heterogeneity;human old age (65+);Image;Impaired cognition;Individual;induced pluripotent stem cell;informant;Infrastructure;instrument;Life Cycle Stages;Liquid substance;Longitudinal Studies;Measures;metropolitan;mild cognitive impairment;Minority;molecular phenotype;Nature;Neurodegenerative Disorders;Neurologic;neuropathology;Neuropsychology;normal aging;novel;novel strategies;Nuclear Pore Complex;outreach;Participant;Plasma;Population;Population Heterogeneity;Positron-Emission Tomography;pre-clinical;Procedures;programs;Protocols documentation;Psychometrics;racial difference;recruit;repository;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Risk;Sampling;Scientist;Severities;Sex Differences;Sleep;statistics;tau Proteins;tau-1;Third-Party Payer;tool;Training;Vascular Dementia

PROJECT_TITLE: Clinical Core


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Narrative Using a mouse model where classical STAT3 signaling is knocked out only in excitatory neurons, we will investigate the role of the neuronal JAK/STAT pathway in brain inflammation and excitability via transcriptomic, genomic, and functional studies that have the promise of identifying potential disease-modifying therapies.

PI_NAMEs: BROOKS-KAYAL, AMY R.;RUSSEK, SHELLEY J (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acute;Adverse effects;Animal Model;Astrocytes;Attenuated;Binding Sites;biocytin;Brain;brain cell;Brain Diseases;Brain Injuries;Brain-Derived Neurotrophic Factor;Ca(2+)-Calmodulin Dependent Protein Kinase;calmodulin-dependent protein kinase II;Cell Nucleus;cell type;Cells;Chromatin;chromatin remodeling;Computer Models;conditioned fear;Cyclic AMP;Data;Development;dimer;Disease;Disease Progression;DNA;Electrophysiology (science);Encephalitis;Enterobacteria phage P1 Cre recombinase;Epilepsy;Epileptogenesis;excitatory neuron;Frequencies;GABA Receptor;GABA-A Receptor;Gene Expression Regulation;gene network;gene repression;Gene Silencing;Genes;Genetic Transcription;Genome;Genomics;glial activation;Glutamate Receptor;Glutamates;granule cell;GRM5 gene;Hippocampus;Human;Immunity;Impaired cognition;Individual;inducible Cre;Inflammation;Inflammatory;inflammatory marker;inhibitor;inhibitory neuron;Injections;Intervention;JAK2 gene;Janus kinase;kainate;Kainic Acid;Knock-out;Knowledge;Laboratories;Long-Term Depression;Malignant neoplasm of brain;Mediating;Mediator;Medical;Memory impairment;Metabotropic Glutamate Receptors;Microglia;Modeling;Molecular;molecular imaging;Monitor;Morphology;mouse model;multiple omics;Mus;N-Methyl-D-Aspartate Receptors;Nerve Degeneration;neural;neural circuit;Neuroglia;neuroinflammation;neuronal excitability;Neuronal Plasticity;Neurons;Neuropharmacology;neurotransmission;new therapeutic target;Pathogenesis;Pathologic;Pathway interactions;Patients;Pharmacology;Pilocarpine;Population;Predisposition;prevent;promoter;Property;Prosencephalon;Protein Tyrosine Kinase;receptor;Receptor Down-Regulation;receptor downregulation;Receptor Signaling;Recurrence;Reporting;response;response to injury;RNA;Role;Seizures;Signal Transduction;Slice;Sorting;STAT protein;STAT3 gene;Status Epilepticus;Symptoms;Synaptic plasticity;synaptogenesis;Tamoxifen;targeted treatment;Temporal Lobe Epilepsy;Testing;Therapeutic Intervention;Tissues;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Organisms;Wild Type Mouse

PROJECT_TITLE: The STAT3 Response of Excitatory Neurons to Epileptogenic Brain Injury


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PI_NAMEs: XIONG, CHENGJIE  (contact)

PROJECT_TERMS: Action Research;Alzheimer's Disease;Collaborations;Consult;Consultations;Data;Data Analyses;data management;Data Set;data submission;Databases;design;Informatics;Lead;Methodology;novel;Progress Reports;Quality Control;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Statistical Methods;statistics;Techniques;Work

PROJECT_TITLE: Core C:  Data Management & Statistical


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Nutrition;Orphan Drug;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE KSHV, the viral agent of Kaposi sarcoma (KS), alters expression of cellular genes involved in iron metabolism in order to acquire iron for growth while resisting an iron-dependent form of cell death known as ferroptosis. Iron addiction coupled with ferroptosis resistance is a feature of several tumors and activation of ferroptosis is considered a promising therapeutic strategy, but the relationship between iron and ferroptosis in KS has not yet been characterized or explored as a treatment option. Our goal is to address this deficit by (i) defining the importance of iron in KSHV pathogenesis, (ii) understanding how KSHV-infected cells resist ferroptotic death and (iii) evaluating the therapeutic potential of ferroptosis activation in an in vivo KS tumor model.

PI_NAMEs: SKALSKY, REBECCA L (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;addiction;Address;Affect;African;AIDS related cancer;Amino Acid Transporter;Amino Acids;antagonist;Antioxidants;antiporter;antiretroviral therapy;Cancer Etiology;Catalytic Domain;Cell Death;cell growth;Cells;Cellular biology;Cellular Metabolic Process;Cessation of life;clinical epidemiology;cofactor;combat;conventional therapy;Coupled;Cysteine;Cystine;Data;Development;Diagnosis;Disease;Drug Metabolic Detoxication;Elements;Endothelial Cells;enzyme substrate;epidemiology study;Equilibrium;extracellular;Gene Expression;Genes;Glutamates;Glutathione;Goals;Growth;Heme;Herpesviridae;HIV;HIV Infections;HIV-1;Homeostasis;Human Herpesvirus 8;Iatrogenic Kaposi's Sarcoma;Immune;improved;In Vitro;in vivo;Incidence;Infection;innovation;interdisciplinary approach;Iron;iron metabolism;Kaposi Sarcoma;Knowledge;Limes;Lipid Peroxidation;Lipid Peroxides;Lipids;lymph nodes;Lymphatic Endothelial Cells;Malignant Neoplasms;Modeling;Morbidity - disease rate;mortality;neoplastic cell;novel;novel therapeutics;Oncogenic;Oral mucous membrane structure;Organ;overexpression;Oxidation-Reduction;oxidative damage;Oxidative Stress;Pathogenesis;Pathway interactions;Persons;Phenotype;Phospholipids;Predisposition;prevent;programs;Proteins;Research;Resistance;Resource-limited setting;response;Skin;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;transcriptome;tumor;tumor growth;Up-Regulation;uptake;Viral;Virus;virus host interaction;Visceral;Western World

PROJECT_TITLE: KSHV Manipulates Host Iron Metabolism and Ferroptotic Cell Death Pathways, Creating Novel Vulnerability Points for Therapeutic Intervention.

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: PERRIN, RICHARD JUSTIN (contact)

PROJECT_TERMS: Address;African American population;age effect;Aging;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Atrophic;Authorization documentation;Autopsy;autosomal dominant Alzheimer's disease;Biochemical;Brain;Brain Diseases;Brain scan;brain tissue;Cerebrovascular Disorders;Clinical;clinically relevant;Collaborations;Communication;Communities;Data;data management;data sharing;Database Management Systems;Databases;Dementia;Deposition;Development;Diagnosis;Diagnostic;Disease;DNA;Education;education research;Electronics;Equipment and supply inventories;Evaluation;expiration;Family;Feedback;Formalin;Fostering;Freezing;Functional disorder;Future;Genetic;Gliosis;Goals;Hemorrhage;Histology;hyperphosphorylated tau;immunoreactivity;Impaired cognition;improved;Individual;Infarction;Inherited;interest;Investigation;Measures;Memory;Mission;Molecular;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;neuron loss;neuropathology;next generation;Not Hispanic or Latino;Older Population;outreach;Pallor;Paraffin Embedding;Parietal Lobe;Participant;Pathologic;Pathology;Patients;Persons;Phenotype;prevent;Process;Proteins;racial difference;recruit;Registries;Reporting;repository;Research;RNA;Sampling;Scientist;Severities;Signs and Symptoms;Specimen;statistics;tau Proteins;tau-1;Techniques;Testing;Time;Tissue Sample;Tissues;transcriptome sequencing;Universities;Vascular Dementia;Vascular Diseases;Washington;white matter;Work;Writing

PROJECT_TITLE: Core D:  Neuropathology


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Abnormal chromosome numbers in eggs or sperm cause developmental disabilities or miscarriage. These abnormalities often arise because of improper separation of chromosomes caused by defects in meiotic homologous recombination. This project will address fundamental questions about the mechanism and control of recombination and thus is of direct relevance to human reproductive health and disease.

PI_NAMEs: KEENEY, SCOTT  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;Area;ataxia telangiectasia mutated protein;Behavior;Biological Assay;Biology;Cells;Chromatin;chromosome missegregation;chromosome number abnormality;Chromosomes;Complex;Defect;Developmental Disabilities;DNA;DNA Damage;DNA Double Strand Break;DNA Sequence;Double Strand Break Repair;egg;Ensure;Evolution;Excision;Genetic Recombination;Genome;genome integrity;Genome Stability;genome-wide;genomic locus;Heritability;homologous recombination;Human;innovation;Location;male;Mammals;Maps;Meiosis;Meiotic Recombination;Methods;Molecular;Mus;Mutation;nuclease;Nucleotides;offspring;Outcome;Pathway interactions;Process;programs;Pseudoautosomal Region;Regulation;repaired;Reproductive Health;reproductive system disorder;Research;Resolution;response;Risk;risk minimization;Role;Saccharomyces cerevisiae;segregation;Sex Chromosomes;Sexual Reproduction;Shapes;sperm cell;SPO11 gene;Spontaneous abortion;Sterility;Structure;Testing;tool;Trans-Activators;whole genome;Work;Y Chromosome;Yeasts

PROJECT_TITLE: Mechanism and regulation of meiotic recombination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: DENNY, ANDREA  (contact)

PROJECT_TERMS: Address;African American;African American population;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Awareness;Biological Markers;Black race;Caring;Catchment Area;Censuses;Clinical;clinical care;Clinical Research;Cognitive;cohort;Collaborations;Collection;Communities;community advisory board;community engagement;Community Outreach;community partners;County;Coupled;Cultural Sensitivity;Data;Dementia;demographics;Development;Diagnosis;Diagnostic;Disease;Education;Education and Outreach;education research;Educational Activities;Educational workshop;effectiveness evaluation;Eligibility Determination;eligible participant;Faculty;follow-up;Fostering;Goals;Grant;Health Professional;health training;healthy aging;high school;Illinois;imaging study;Individual;interest;Joints;lectures;Link;Longitudinal cohort;meetings;Memory;metropolitan;Missouri;novel;Older Population;outreach;Participant;participant enrollment;participant retention;Persons;Population;Printing;programs;racial difference;Recommendation;recruit;Research;Research Personnel;Residencies;Resources;retention rate;Role;Rural;Scientist;stem;Students;Thinking;Training;Training and Education;training opportunity;Update;volunteer;web-based tool;Work

PROJECT_TITLE: Core E:  Outreach, Recruitment & Engagement


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: FAYETTEVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: Project Narrative – Overall The University of Arkansas - Fayetteville (U of A) will establish the Arkansas Integrative Metabolic Research Center (AIMRC). Through NIH COBRE funding, the AIMRC will help cultivate a critical mass of investigators focused on interdisciplinary collaborative research to understand the role of cell and tissue metabolism in disease and aid in solving human health problems such as cancer, diabetes, and obesity.

PI_NAMEs: QUINN, KYLE PATRICK (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Arkansas;Biochemistry;Bioenergetics;Biological Assay;Biological Sciences;Biomedical Engineering;Biomedical Research;cancer therapy;Cells;Centers of Research Excellence;Chemistry;Collaborations;Collection;college;Complex;computer science;computing resources;Core Facility;Country;Data Science;Data Science Core;Development;Development Plans;Diabetes Mellitus;Disease;Domestic Fowls;Epithelium;Equipment;Exercise;Extramural Activities;Faculty;faculty research;Flow Cytometry;Foundations;Funding;Genetic Code;Goals;Health;High Performance Computing;Human;Image;Imaging technology;insight;Institution;Interdisciplinary Study;Investments;Label;large datasets;Lead;Malignant Breast Neoplasm;Malignant Neoplasms;Medical;medical schools;Melanoma;member;Mentors;Mentorship;Metabolic;metabolic imaging;Metabolism;Methionine Metabolism Pathway;Microscopy;Mission;Mitochondria;Molecular Biology;Morphogenesis;multidisciplinary;Neoplasm Metastasis;nerve supply;new therapeutic target;novel therapeutic intervention;Obesity;Optics;Phase;Pilot Projects;Post-Translational Protein Processing;programs;Radiation Oncology;recruit;repaired;Research;Research Personnel;Research Project Grants;Resources;Role;Science;Services;Signal Transduction;Spectrum Analysis;synergism;Techniques;Technology;Tissues;tool;United States National Institutes of Health;Universities;Veterinary Schools


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

ORG_STATE: CA

PHR: The objectives of this proposal are to develop aging-relevant human neuron models of late-onset Alzheimer's disease, using direct reprogramming technology in combination with CRISPR/Cas9-mediated gene editing, and to dissect the underlying mechanisms of apoE2's protective roles in Alzheimer's disease. The outcomes of the proposed studies will likely identify novel targets for anti-Alzheimer's disease drug development, especially for treating or protecting late-onset Alzheimer's disease.

PI_NAMEs: HUANG, YADONG  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Animal Model;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Cell Aging;Cell Differentiation process;Cell Line;Cell Reprogramming;cell type;Cells;Complement;CRISPR/Cas technology;Disease;disease model;drug development;drug discovery;Elements;Epigenetic Process;Fibroblasts;gene editing technology;Generations;Genes;genetic risk factor;Genotype;Goals;Human;human disease;human induced pluripotent stem cells;induced pluripotent stem cell;induced pluripotent stem cell technology;Late Onset Alzheimer Disease;Late-Onset Disorder;Mediating;Modeling;Modification;Molecular;mouse model;Mus;Mutation;Nature;nerve stem cell;Neurons;novel;Outcome;Pathogenesis;Pathologic;Pathology;Phenotype;prevent;Process;Property;Protein Isoforms;Regenerative Medicine;Reporting;Research;Role;Signal Pathway;Source;species difference;stem cell biology;Technology;therapy development;Transgenic Mice;Variant

PROJECT_TITLE: Study the Protective Roles of ApoE2 in Alzheimer's Disease Using Reprogrammed Isogenic Cells


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Administrator;Advisory Committees;Arkansas;Bioenergetics;Biomedical Research;career development;Cells;Centers of Research Excellence;cohort;Collaborations;Core Facility;Data Science;Development;Development Plans;Disease;empowerment;Ensure;Evaluation;Faculty;faculty mentor;Faculty Recruitment;Funding;Funding Opportunities;Goals;Image;imaging science;Interdisciplinary Study;member;Mentors;Mentorship;Metabolic;metabolic imaging;Metabolism;Methods;Optics;Phase;Pilot Projects;Productivity;programs;repaired;Research;Research Infrastructure;Research Personnel;Research Support;Resource Allocation;Role;Secure;Spectrum Analysis;success;Teacher Professional Development;Technology;Tissues;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: KARCH, CELESTE MARIE (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Age;age related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Architecture;Area;Astrocytes;autosomal dominant Alzheimer's disease;biobank;Biological Assay;Biological Markers;Biological Models;Biological Process;Brain;brain magnetic resonance imaging;brain tissue;Budgets;C9ORF72;Cell Line;cell type;Cells;Charge;Clinical;Cognition;cohort;Collaborations;Collection;Communities;data management;data sharing;Database Management Systems;demented;Dermal;Disease;disorder risk;drug discovery;Electronics;ethnic diversity;European;Family;Family history of;Fibroblasts;Frontotemporal Lobar Degenerations;Future;Gene Expression;Genetic;genetic architecture;genome editing;Genomics;Goals;Grant;Human;Human Genome;human stem cells;Idiopathic Parkinson Disease;Image;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inherited;Laboratories;Late Onset Alzheimer Disease;Link;Liquid substance;Microglia;Molecular;Molecular Analysis;Mutation;Neurodegenerative Disorders;Neurons;neuropathology;novel;novel marker;Oligodendroglia;Organoids;Parkinson Disease;Participant;Pathogenesis;Pathologic;Pathology;Phase;Population;Positron-Emission Tomography;presenilin-1;presenilin-2;Process;Productivity;Program Research Project Grants;protein aggregation;Qualifying;rare variant;Research;Research Personnel;Resources;risk variant;Sampling;Services;skin biopsy;Somatic Cell;specific biomarkers;statistics;stem cell model;stem cells;tool;transcriptome;TREM2 gene;Variant;Work

PROJECT_TITLE: Core F:  Biomarker


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Cannabinoid Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Therapeutic Cannabinoid Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Biased ligand design is an attractive approach for designing drugs that target a particular signaling pathway with high specificity and selectivity to minimize side effects, however, it is also a grand challenge due to lack of computational tools. Also, there is an urgent need to expand the druglike chemical space for promising drug targets which have plenty of potent ligands developed, but unfortunately, no approved drugs. We plan to apply artificial intelligence (AI) techniques to overcome the two challenges by developing interaction profile scoring function models to enable biased ligand design and Drug-GAN models to achieve de novo novel chemical structure design.

PI_NAMEs: WANG, JUNMEI  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Adverse effects;Affinity;Agonist;Algorithms;antagonist;application programming interface;Artificial Intelligence;Binding;Biological Assay;Calibration;cannabinoid receptor;Chemical Structure;Chemicals;CNR1 gene;CNR2 gene;Coin;Computational algorithm;computational platform;Computer Assisted;computerized tools;Computers;Computing Methodologies;Databases;design;Docking;drug candidate;Drug Design;drug development;drug discovery;Drug Modelings;Drug Targeting;drug-like compound;Evaluation;Future;Generations;generative adversarial network;Goals;Grant;improved;Internet;Learning;Libraries;Ligands;machine learning algorithm;Measures;Methods;Modeling;Modernization;Modification;Molecular;network models;novel;novel therapeutics;Outcome;Pathway interactions;Pattern;Pharmaceutical Preparations;Play;Protocols documentation;Public Domains;rational design;Reporting;Research;Resources;Role;screening;Series;side effect;Signal Pathway;Signal Transduction;Specificity;statistics;success;System;Techniques;tool;Training;Validation;virtual screening;web app;web-based tool

PROJECT_TITLE: AI-Powered Biased Ligand Design

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Metabolic activity is dynamically regulated across cell states in development and disease and can contribute to the establishment of cell fate through metabolite-dependent effects on chromatin organization. The goal of this research proposal is to identify the mechanisms by which metabolic pathways drive chromatin changes to support the exit from naïve pluripotency in mouse embryonic stem cells. These studies will enhance our understanding of how metabolic control of gene expression enables successful execution of developmental programs.

PI_NAMEs: JACKSON, BENJAMIN TONNU (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Acetates;Acetyl Coenzyme A;Acetylation;Affect;antiporter;ATP Citrate (pro-S)-Lyase;Binding;Biochemical Reaction;Biological Assay;C-terminal binding protein;career;Cell Fate Control;cell fate specification;cell type;Cells;Chemicals;ChIP-seq;Chromatin;chromatin remodeling;citrate carrier;Citrates;clinical training;cofactor;Competence;Complex;Cytoplasm;Data;defined contribution;Deposition;Development;developmental disease;Disease;Embryonic Development;embryonic stem cell;Enzymes;Equilibrium;Excision;Exhibits;Experimental Genetics;experimental study;Gene Expression;Gene Expression Regulation;Genetic;genetic approach;Genetic Transcription;genomic locus;Genomics;Glucose;Goals;Histone Acetylation;histone modification;insight;Laboratories;LIF gene;Link;Malates;Mass Spectrum Analysis;Measures;Mediating;MEKs;Memorial Sloan-Kettering Cancer Center;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;Mitochondria;Modification;Mouse Embryonic Stem Cells;mutant;NADH;Output;Oxidation-Reduction;pharmacologic;Physicians;pluripotency;pluripotency factor;Process;programs;Pyruvate;Regulation;Reporter;Reporting;Research Proposals;Scientist;self-renewal;sensor;Shapes;Signal Transduction;Specific qualifier value;stem cell differentiation;Supplementation;Testing;tool;Training;Transcription Repressor;Western Blotting;Work

PROJECT_TITLE: Metabolic control of exit from naïve pluripotency

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: CRUCHAGA, CARLOS  (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Autopsy;biobank;Biocompatible Materials;Bioinformatics;Biological databases;Biological Markers;Biology;Biopsy;Blood;Blood specimen;Brain;brain tissue;C9ORF72;Characteristics;Clinical;Collaborations;Communities;Complex;Data;Data Analyses;data management;data sharing;Databases;Dementia;Deposition;Developed Countries;Disease;disease classification;disorder risk;DNA;DNA Library;exome sequencing;Face;Family;Frontotemporal Dementia;functional genomics;Genes;Genetic;Genetic Diseases;genetic information;genetic risk factor;Genetic study;genome sequencing;genome wide association study;Genomics;Genotype;Goals;granulin;Individual;Intention;interest;kindred;Lead;MAPT gene;molecular marker;Molecular Profiling;Multiomic Data;Mutation;Neurodegenerative Disorders;neuropathology;new therapeutic target;novel;novel marker;Parietal Lobe;Participant;Phenotype;Physicians;Plasma;polygenic risk score;Population;presenilin-1;presenilin-2;Process;protein aggregation;protein misfolding;Proteomics;Qualifying;recruit;repository;Research;Research Personnel;risk prediction model;RNA;Saliva;Sampling;statistics;tau Proteins;Tissues;transcriptome sequencing;transcriptomics;whole genome

PROJECT_TITLE: Core G:  Genetics & High Throughput Omics


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: SNIDER, BARBARA JOY (contact)

PROJECT_TERMS: Acceleration;Address;Aging;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;career;career development;Clinical;clinical translation;Competence;Consultations;Coupled;Development;Development Plans;Disabled Persons;Discipline;Disease;Education;education research;Educational Status;effective therapy;Ensure;Environment;evidence base;experience;Exposure to;externship;Faculty;Fellowship;Funding;Future;Goals;Health Professional;Individual;innovation;interest;International;investigator training;Libraries;medical schools;meetings;Mentors;Mentorship;Minority Groups;minority trainee;older adult;outreach;outreach program;Physicians;Population;Postdoctoral Fellow;Prevalence;prevent;Program Development;programs;recruit;Research;Research Personnel;Research Project Grants;Research Training;Residencies;Resources;responsible research conduct;Scholars Program;Scientist;senior faculty;Senior Scientist;Series;Services;skills;success;tool;Training;Training Programs;Translational Research;Underrepresented Minority;Underrepresented Populations;Universities;visiting scholar;Washington;Woman

PROJECT_TITLE: Research Education Component


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Pediatric;Sleep Research;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative In today's twenty-four-hour society, women suffer disproportionately from the negative health consequences associated with sleep loss. Since negative sleep responses to daily challenges may be a predisposing factor for morbidity, it is important to determine the influences of biological sex and reproductive development on the ability to tolerate sleep loss. These experiments use EEG/EMG recording in juvenile and adult mouse models to determine whether genetic, gonadal, and phenotypic determinants of sex are predisposing factors for sleep dysregulation during and after sleep loss.

PI_NAMEs: PAUL, KETEMA N (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Adolescent;Adult;Adult women;Animals;Area;Biological Markers;biological sex;Birth;Brain;Chromosomes;Chronic;Data;Development;dosage;Electrodes;Electroencephalography;Electromyography;Exhibits;experimental study;Female;Feminization;Four Core Genotypes;gene complementation;Genes;Genetic;Goals;Gonadal Hormones;Gonadal Steroid Hormones;Health;Homeostasis;Hour;Implant;improved;Incidence;Injections;Life;Link;male;Masculine;men;Modernization;Morbidity - disease rate;mouse model;Mus;Neonatal;neonatal mice;neonate;non rapid eye movement;Organizational Change;Pathology;Pattern;Phase;Phenotype;Phenotypic Sex;Play;Ploidies;postnatal;Predisposing Factor;prepuberty;pressure;Property;Puberty;Recovery;reproductive development;response;Role;Severities;sex;Sex Chromosomes;Sex Differences;Sexual Development;Sleep;Sleep Deprivation;Sleep Disorders Therapy;Sleep disturbances;Sleep Fragmentations;sleep regulation;Slow-Wave Sleep;Societies;sry Genes;Testing;testis determining factor;Testosterone Propionate;Woman;Women's prevalence;Work;X Chromosome;Y Chromosome

PROJECT_TITLE: Sex differences in the ability to recover from sleep loss: the roles of development and sex chromosome dosage


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative This project is highly relevant to public health because it addresses the need for a resource- appropriate, scaleable tobacco cessation intervention for low-resource settings. There is limited knowledge about how best to translate effective interventions from high-resource settings to low-resource settings and how to use technology to support the ongoing training of busy practitioners. Upon completion, our study will deliver practice-focused strategies that can be adapted to other health issues and other low-resource settings.

PI_NAMEs: RAMANADHAN, SHOBA ;VISWANATH, KASISOMAYAJULA  (contact)

PROGRAM_OFFICER_NAME: PARASCANDOLA, MARK

PROJECT_TERMS: Address;Behavior Therapy;Boston;brief advice;Cancer Control;cancer prevention;Cellular Phone;Cessation of life;Clinic;Cluster randomized trial;Communication;comparison control;Control Groups;Counseling;Country;Credentialing;Dana-Farber Cancer Institute;Data;Data Collection;Dental Clinics;Disease;effective intervention;effectiveness evaluation;effectiveness/implementation study;evidence base;Evidence based program;Exploration, Preparation, Implementation, and Sustainment;Female;Focus Groups;follow-up;Foundations;Frontline worker;Goals;Health;health care delivery;health care settings;Healthcare Systems;Human Resources;hybrid type 1 trial;implementation determinants;implementation framework;implementation outcomes;implementation science;Income;India;Individual;informant;innovation;Intervention;Interview;Knowledge;Link;Literature;low and middle-income countries;male;Malignant Neoplasms;Methods;Modeling;Nongovernmental Organizations;Outcome;Patients;Perception;Pharmacotherapy;pilot test;Population;practice setting;Primary Health Care;primary health center;Program Effectiveness;programs;Public Health;Public Health Schools;Randomized, Controlled Trials;Research;Research Personnel;Resource-limited setting;Resources;routine screening;Running;scale up;Services;Smoke;Smokeless;Smokeless Tobacco;social media;Surveys;Technology;Testing;Time;Tobacco;tobacco cessation intervention;tobacco control;tobacco screening;Tobacco smoke;Tobacco use;Tobacco Use Cessation;tobacco user;Tobacco-Related Carcinoma;Training;Training Support;Translating;treatment arm;treatment as usual;Tuberculosis;United States Public Health Service;Universities;World Health Organization

PROJECT_TITLE: Adapting and evaluating a brief advice tobacco intervention in high-reach, low-resource settings in India

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


PI_NAMEs: THALLAPURANAM, SURESH KUMAR KRISHNASWAMY (contact)

PROJECT_TERMS: Acceleration;Aging;Applications Grants;Arkansas;ATP Synthesis Pathway;Bioenergetics;Biological Assay;Biological Models;Biomedical Research;Cells;Cellular Metabolic Process;Centers of Research Excellence;clinical translation;Collaborations;Communities;Consultations;Coupling;data acquisition;Data Analyses;Data Science Core;design;Disease;Education;Educational workshop;Energy Metabolism;Experimental Designs;experimental study;Flow Cytometry;Fostering;Foundations;Future;Generations;Glycolysis;Goals;Grant;Health;Image;imaging facilities;imaging science;Industry;innovation;insight;Institution;instrument;interdisciplinary collaboration;Malignant Neoplasms;Measurement;Measures;member;Membrane Potentials;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Mitochondrial Diseases;mitochondrial membrane;mitochondrial metabolism;novel;Oxygen Consumption;Pathway interactions;Phase;Preparation;programs;Proton-Motive Force;Protons;Publications;Reactive Oxygen Species;Research;Research Methodology;Research Personnel;Resolution;Respiration;respiratory;Role;Sampling;Services;Spectrum Analysis;Structure;synergism;Techniques;Technology;Tissues;Training;United States National Institutes of Health;Universities;Vision;wound healing

PROJECT_TITLE: Bioenergetics Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Eye Disease and Disorders of Vision

ORG_CITY: TAMPA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Narrative  The long term goal of this proposal is to characterize the microstructural thickness variations of the tear film lipid layer and their association with clinical characteristics of dry eye disease. This work will not only advance our understanding of the factors that contribute to human precorneal tear film dynamics and help identify novel diagnostic biomarkers, but also inform the development of new therapeutics to slow or prevent the development of dry eye disease.

PI_NAMEs: BAI, YUQIANG  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Address;Agreement;Air;Anterior;aqueous;Area;Biological Markers;Characteristics;Clinical;Cornea;Desiccation;Development;Diagnosis;diagnostic biomarker;Disease;Dry Eye Syndromes;Environment;evaporation;Exclusion;Eye;eye dryness;Film;Goals;Grant;Homeostasis;Human;Imaging Techniques;in vivo;Inflammation;interest;Lasers;Link;Lipids;Literature;Measurement;Measures;meter;Methods;Microscopy;National Eye Institute;novel;novel diagnostics;novel therapeutics;ocular surface;Optical Methods;Pattern;Phase;Play;Positioning Attribute;Predisposition;prevent;psychologic;Research;Resolution;Role;Scanning;Severities;Source;Stress;Structure;Sum;Surface;Surface Tension;Symptoms;System;Techniques;Testing;Thick;Thinness;United States National Institutes of Health;Validation;Variant;Work

PROJECT_TITLE: Correlating the microstructural thickness variations of the tear film lipid layer with clinical characteristics of dry eye with a novel optical method

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The maintenance of chromosome integrity is critical for preventing genetic disorders and avoiding cancer. The work described in this proposal will investigate how chromosomes break, and how cells choose different options for repairing that damage. Factors that affect chromosome pairing and orderly DNA replication will be studied to determine how they act to maintain the organization of genetic material in the nucleus, an important factor for its normal function.

PI_NAMEs: GOLIC, KENT G (contact)

PROJECT_TERMS: Affect;Aneuploidy;Area;cancer cell;Cancerous;Cell Nucleus;Cell Physiology;Cells;Centromere;Chromosomal Breaks;Chromosome Breakage;Chromosome Pairing;chromosome replication;Chromosome Structures;Chromosomes;daughter cell;Dicentric chromosome;DNA biosynthesis;DNA Replication Timing;Drosophila melanogaster;Euchromatin;Eukaryota;experimental study;Failure;Frequencies;Gene Expression;Genes;Genetic Diseases;Genetic Materials;Genetic Recombination;Genome;Genome Stability;Germ Cells;Germ Lines;Health;Heterochromatin;Histones;Human;Investigation;Maintenance;male;Malignant Neoplasms;Meiosis;Mitotic Chromosome;Modeling;Mutation;Pattern;prevent;Proteins;repaired;Site;Testing;transmission process;Variant;Work;Yeasts

PROJECT_TITLE: Chromosome breakage, pairing and replication: impacts on cell fate and function


NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Vector-Borne Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The work proposed here seeks to develop and apply powerful machine-learning based software tools for evolutionary genetic inference in humans, mosquito vectors, and other species. Such efforts have important health implications, as they can identify genes involved in adaptation, which in humans are often associated with disease and in mosquitos are often associated with resistance to insecticides and other control efforts.

PI_NAMEs: SCHRIDER, DANIEL R (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Aedes;Affect;Area;Computing Methodologies;Culicidae;Data;Data Analyses;Data Set;Development;Dimensions;Disease;Evolution;Genes;Genetic;Genetic Variation;Genome;genomic data;Genomics;Health;Human;Human Genome;improved;Insecticides;insight;Machine Learning;machine learning method;Methodology;Methods;Natural Selections;novel;novel strategies;Pattern;Phylogenetic Analysis;Play;Population;Proliferating;Public Health;Research;Research Personnel;Resistance;Role;Sampling;Sequence Alignment;Series;Shapes;Software Tools;statistics;success;Testing;Time;time use;tool;Variant;vector;vector mosquito;Work

PROJECT_TITLE: Advancing evolutionary genetic inference in humans and other taxa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: SCHENECTADY

ORG_NAME: UNION COLLEGE

PHR: PROJECT NARRATIVE Increasingly, students in four-year undergraduate Biomedical Engineering programs are expected to gain advanced knowledge and enhanced training for workforce preparedness by engaging in learning experiences outside fundamental engineering content taught in the classroom, such as: (1) immersion and observation in a clinical setting, and (2) understanding the process and pathways of translating biomedical innovation towards commercialization for clinical and patient use. This project seeks to design and deliver valuable hands-on, learner-centered content to Union College's Biomedical Engineering majors through an intensive Summer Clinical Immersion Program at Albany Medical College where students will identify unmet needs in the clinic, feeding directly into a sustained educational experience through an expanded Capstone Design Course Sequence that encourages exploration of the translation pathway while also providing the expertise, resources, and mentoring necessary for students to jump-start their solutions towards commercialization. Union's proposed Summer Clinical Immersion Program and enhanced Capstone Design Course Sequence will not only create solutions to meet current medical needs but will also better prepare undergraduates to contribute immediately to established or startup biomedical device companies, bolster students' understanding and expertise in biomedical device development, and empower them to confidently navigate the path from initial solution to final product.

PI_NAMEs: CURREY, JENNIFER A. (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TITLE: SCIP, HOP & JUMP: Summer Clinical Immersion Program, Hands on Prototyping, and Jump-starting Design Projects towards Translation


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Infectious Diseases;Interstitial Cystitis;Neurosciences;Urologic Diseases;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Lower Urinary Tract Symptoms (LUTS) that a patient perceives are a function of how information flows from the bladder to the brain and how it is interpreted. Growing evidence suggests urinary tract infections (which are far more prevalent in females and than in males) in early childhood are associated with LUTS in later life. Using mouse models, we wish to study how recurrent early life urinary tract infections and the accompanying inflammation alter bladder-to-brain signaling, if these changes are also accompanied by psychological consequences (such as anxiety- and depression-like behavior), and if these changes persist across the lifespan in female mice.

PI_NAMEs: ZDERIC, STEPHEN ANTHONY (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Acrolein;Acute;Address;Adult;Age;Anxiety;anxiety-like behavior;Astrocytes;Basic Science;Behavior;Bladder;Bladder Dysfunction;Brain;brain dysfunction;Brain region;care costs;Catheters;Cell Nucleus;Cells;Clinical;Clinical Research;Communication;comorbidity;Conscious;Cyclophosphamide;Cystitis;cytokine;Data;early childhood;Encephalitis;Esthesia;Etiology;Event;experience;experimental study;Female;Frequencies;frontal lobe;Functional disorder;Future;Hippocampus;IL18 gene;in vivo monitoring;indexing;Inflammasome;Inflammation;Inflammatory;Injections;insight;Interleukin-1 beta;Intervention;late life;Lead;Life;life span;Link;locus ceruleus structure;Low Prevalence;lower urinary tract symptoms;Macrophage;male;Maps;Mental Depression;Microglia;Modeling;mouse model;Mus;Neonatal;Neurons;novel therapeutics;Obstruction;optogenetics;Pathway interactions;Patients;pharmacologic;Phenotype;postnatal;Prosencephalon;psychologic;Quality of life;Recurrence;reduce symptoms;Regulation;Reporting;Research;Rodent;Role;Sensory;Signal Transduction;Specificity;Testing;Therapeutic;Time;tool;Urinary tract infection;Urination;Urologist;Women's prevalence;Women's study

PROJECT_TITLE: Early life bladder inflammatory events in female mice lead to subsequent LUTS in adulthood

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science

PI_NAMEs: RAJARAM, NARASIMHAN  (contact)

PROJECT_TERMS: Acceleration;Aging;Applications Grants;Arkansas;Award;Bioenergetics;Biological Models;Biology;Biomedical Research;Cell Physiology;Cells;Cellular Metabolic Process;Centers of Research Excellence;clinical translation;Collaborations;Communities;Consultations;data acquisition;Data Analyses;Data Science;Data Science Core;Disease;Education;Experimental Designs;Fostering;Foundations;Functional disorder;Funding;Future;Goals;Grant;Image;Image Analysis;imaging approach;Imaging Techniques;Imaging technology;innovation;insight;instrument;interdisciplinary collaboration;Label;Malignant Neoplasms;Medicine;member;Metabolic;metabolic imaging;Metabolism;Microscopy;novel;Optics;Phase;Preparation;programs;Publications;Research;Research Methodology;Research Personnel;Resolution;Resources;Role;Sampling;Services;Spectrum Analysis;Structure;synergism;Techniques;Technology;temporal measurement;Tissues;Training;Translations;United States National Institutes of Health;Universities;Vision;Visualization;wound healing

PROJECT_TITLE: Imaging & Spectroscopy Core


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_DEPT: NEUROSCIENCES

PHR: Project NARRATIVE (two or three sentences, lay summary level) Developmental biology is an interdisciplinary science, incorporating cell and molecular biology, genetics, biochemistry and bioinformatics in whole-animal model systems at the leading edge of modern biomedical research. Training predoctoral and postdoctoral researchers in developmental biology provides the next generation of biomedical researchers with experience in a wide range of model systems for important discoveries in human health and disease.

PI_NAMEs: KWAN, KRISTEN M;YOST, H. JOSEPH  (contact)

PROJECT_TERMS: Developmental Biology;Training Programs

PROJECT_TITLE: Developmental Biology Training Program


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: WU, XINTAO  (contact)

PROJECT_TERMS: Acceleration;Algorithms;Applications Grants;Arkansas;Artificial Intelligence;Big Data;Bioenergetics;Bioinformatics;Biological Models;biomedical informatics;Biomedical Research;Centers of Research Excellence;Charge;Cloud Computing;cohort;Collaborations;Communities;computational platform;computing resources;Consultations;Creativeness;Data;Data Analyses;Data Analytics;data management;Data Management Resources;Data Science;Data Science Core;Data Scientist;Data Set;Data Storage and Retrieval;Databases;design;Discipline;Disease;Education;Educational workshop;Energy Metabolism;Experimental Designs;Explosion;Faculty;Fostering;Funding;Future;Genomics;Goals;Growth;High Performance Computing;Human Resources;Hybrids;Image;innovation;interdisciplinary collaboration;interest;Investments;large datasets;member;Metabolic;metabolic phenotype;Metabolism;Methods;mitochondrial metabolism;Modeling;Modernization;neural network;novel;Pediatric Research;Performance;Phase;Preparation;professor;programs;Proteomics;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Role;Science;Services;skills;Spectrum Analysis;Structure;synergism;Systems Biology;systems research;Techniques;Technology;Training;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: Data Science Core


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Health Services;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Sepsis

ORG_CITY: LA JOLLA

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Sepsis is a common and costly syndrome causing 250,000 deaths/year in the USA and despite much research, almost all new therapies have not helped patients survive longer. Artificial intelligence may allow healthcare workers to identify and treat sepsis by using data available from the electronic health record and has shown major promise to help combat sepsis. The goal of my research is to become an expert who can use new technology to improve the care and well-being of people who have sepsis.

PI_NAMEs: WARDI, GABRIEL  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Accident and Emergency department;acute care;Admission activity;Adoption;Algorithms;Antibiotics;Arithmetic;Artificial Intelligence;Biometry;career development;Caring;Cessation of life;Classification;Clinical;clinical phenotype;clinical practice;Clinical Trials Design;cohort;combat;Complex;Continuity of Patient Care;cost;Critical Care;Data;Data Analyses;Decision Making;deep learning algorithm;deep learning model;design;Detection;Deterioration;Development;Development Plans;Diagnosis;Disease;dissemination science;Documentation;Early identification;Early treatment;Electronic Health Record;Emergency Medicine;Evolution;follow-up;Foundations;Goals;Health Personnel;Heart failure;Heterogeneity;high risk;hospice environment;hospital care;hospital readmission;Hospitalization;Hospitals;Hour;Immune response;implementation science;improved;Infection;innovation;Inpatients;International;Intervention;Intravenous;Investigation;large datasets;Liquid substance;Machine Learning;machine learning algorithm;Medication Errors;Mentors;Modeling;mortality;mortality risk;Myocardial Infarction;Natural Language Processing;new technology;novel;novel strategies;novel therapeutics;operation;Organ failure;Patient Care;Patient Discharge;Patient Readmission;Patients;Pattern;Personal Satisfaction;personalized approach;personalized care;personalized intervention;Persons;Phenotype;Physiology;Pilot Projects;Pneumonia;portability;professor;Provider;Public Health;readmission risk;recurrent infection;Research;research and development;Research Priority;Respiratory Failure;Resuscitation;Risk;risk stratification;Scientist;Seminal;Sepsis;septic patients;Septic Shock;Subgroup;Syndrome;Technology;Testing;Therapeutic;Time;Training;Translating;treatment response;Triage;Update;Vasoconstrictor Agents;wearable device;Work

PROJECT_TITLE: Implementation of Continuum of Care Sepsis Phenotyping and Risk Stratification

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Primary Health Care;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PUBLIC HEALTH RELEVANCE Reducing the health burden of substance use disorders depends on rigorously training clinician scientists to conduct patient-oriented addictions research. This Mid-Career Investigator Award will support Dr. Nahvi to enhance her existing mentoring and leadership activities, and to translate findings from research trials to real- world settings. This mentoring and research plan will build research capacity to improve access to and outcomes of substance use disorder treatment.

PI_NAMEs: NAHVI, SHADI  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: adaptive intervention;addiction;Address;Administrator;Adoption;Agonist;American;Award;Behavior;Buprenorphine;care delivery;career;career development;Caring;Clinical;clinical care;Clinical Management;Clinical Research;clinical translation;Consolidated Framework for Implementation Research;COVID-19 pandemic;Data;Decision Making;Dissemination and Implementation;diversity and equity;Dose;Drops;drug abstinence;Drug Prescriptions;drug testing;Drug usage;early experience;early-career faculty;Emergency Situation;Enrollment;Equity;ethnic minority population;Evidence based treatment;experience;Fatality rate;Fellowship Program;flexibility;Frequencies;Funding;future implementation;Goals;Guidelines;Health;Health Personnel;Health Services Accessibility;high risk;Home;implementation science;Improve Access;improved;Institution;interest;Internist;Intervention;Lead;Leadership;Maintenance;marginalized population;Measures;medication for opioid use disorder;Medicine;Mental disorders;Mental Health;Mentors;Mentorship;Methadone;methadone treatment;Methods;Minority Groups;Modeling;mortality;next generation;novel strategies;Nurses;Opioid;opioid epidemic;opioid overdose;opioid treatment program;opioid use;opioid use disorder;Oral;Outcome;Overdose;overdose death;Overdose reduction;overdose risk;pandemic disease;Participant;patient oriented;Patient Self-Report;Patients;Persons;Pharmacy facility;Physicians;pilot test;Policies;Primary Care;Professional counselor;programs;Protocols documentation;public health relevance;racial minority population;Randomized;randomized trial;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;real world application;Recommendation;Regulation;Relapse;Reporting;Research;Research Personnel;Research Training;Resources;response;risk minimization;Safety;SARS-CoV-2 infection;Schedule;Scientist;skills;social stigma;substance use;Substance Use Disorder;substance use treatment;Survivors;Testing;Therapeutic;Tobacco;Tobacco Use Disorder;Toxicology;Training;Training and Infrastructure;Translating;treatment duration;Treatment outcome;treatment risk;Underrepresented Populations;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;Urine

PROJECT_TITLE: Mentoring investigators to improve health outcomes among persons with opioid and tobacco use disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ORG_DEPT: SURGERY

PI_NAMEs: CHEN, YUAN  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Address;analog;Animal Model;anti-PD-L1 antibodies;Biochemical;Biological;Biological Assay;cancer drug resistance;cancer immunotherapy;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;Cells;Cellular Assay;Clinical Research;Clinical Trials;Colorectal Cancer;Complex;Crystallization;Crystallography;Dendritic Cells;drug discovery;Drug Kinetics;drug metabolism;Drug resistance;Enzyme Inhibition;Enzyme Inhibitor Drugs;Enzyme Kinetics;Enzymes;experience;FDA approved;follow-up;Funding;Goals;high throughput screening;Human;human disease;Immune;Immunomodulators;Immunotherapy;improved;In Vitro;in vivo;inhibitor;innovation;insight;interdisciplinary approach;Interferon Type I;Intravenous infusion procedures;Investigation;Knowledge;Lead;lead optimization;Life;Malignant Neoplasms;Mediating;Medical;Methods;Modeling;Modification;Molecular;Multienzyme Complexes;Mutation;neoplastic cell;novel;Oncogenes;Pathway interactions;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;Phase;Phase I/II Clinical Trial;Post-Translational Protein Processing;Progress Reports;Property;Proteins;Publishing;Regulation;Resistance;resistance mutation;response;Site;small molecule;Solid Neoplasm;Stereoisomer;Structure;Structure-Activity Relationship;Sumoylation Pathway;T cell response;targeted treatment;Therapeutic;therapeutic development;therapeutic target;tumor;Tumor Immunity;Ubiquitin;Ubiquitination;United States National Institutes of Health

PROJECT_TITLE: SUMO Modification and Cancer Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(55)R]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Data Science;Neurosciences;Women's Health Research

PI_NAMEs: SONG, YOUNGHYE  (contact)

PROJECT_TERMS: 3-Dimensional;4T1;Adipose tissue;aerobic glycolysis;Arkansas;Automobile Driving;Bioenergetics;Biomedical Engineering;Brain;Brain-Derived Neurotrophic Factor;Breast Cancer Cell;Breast Cancer Model;cancer cell;CD44 Antigens;CD44 gene;Cell Communication;cell type;Cells;Centers of Research Excellence;Central Nervous System;Clinical Data;clinically relevant;Coculture Techniques;cofactor;Collaborations;Collection;Consumption;Data Analyses;data integration;Data Science;Data Science Core;Development;Disease;DLG4 gene;Event;Exposure to;Fatty acid glycerol esters;Fibroblasts;Glucose;Glutamate Receptor;Glutamate-Ammonia Ligase;Glutamates;Glutaminase;Glutamine;Glycolysis;Goals;Growth;Harvest;Image;Immunofluorescence Immunologic;Implant;implantation;improved;In Vitro;in vivo;infiltrating duct carcinoma;Infiltration;inhibitor;Investigation;lactate dehydrogenase A;Link;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Gland Parenchyma;Mammary Neoplasms;Measures;Mediating;Mentors;Mentorship;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;Metastatic breast cancer;Metastatic malignant neoplasm to brain;Methionine Sulfoximine;migration;Mitochondria;model development;Modeling;Molecular;multiphoton imaging;Mus;Neoplasm Metastasis;neoplastic cell;Nerve Fibers;nerve supply;neurite growth;Neurites;Neurotrophic Tyrosine Kinase Receptor Type 2;Noninfiltrating Intraductal Carcinoma;Optics;oxidation;Oxidation-Reduction;Pathologic;Pathway interactions;Phenotype;Phosphorylation;Play;postsynaptic;Production;repaired;Research;Research Design;Role;scaffold;Signal Transduction;Solid;Spectrum Analysis;Spinal Ganglia;Stains;Stromal Cells;Sulfasalazine;synergism;targeted treatment;Testing;Therapeutic;three dimensional cell culture;three-dimensional modeling;Tissue Engineering;Tissues;tool;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;tumor progression;Up-Regulation;Western Blotting;Work

PROJECT_TITLE: Investigating the role of glutamine metabolism in breast tumor innervation and brain metastasis


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: WASHINGTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: HOWARD UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE (Public Health Relevance Statement) Traumatic brain injury (TBI) perturbs the glucose metabolism of the brain and causes energy crisis that accelerates the development of neurodegenerative diseases in needs of a sensitive imaging tool for diagnosis and prognosis. This project introduces a novel glucose detecting CEST MRI to obtain brain glucose images with resolution ~100 times greater than the current PET images to assist clinicians in determining the best treatments for TBI. We still utilize CEST MRI, in concert with multiple advanced MRIs on a rat model of TBI, to evaluate the treatments of neurological impairments in associated with the disruptions of glucose metabolism.

PI_NAMEs: TU, TSANG-WEI  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acceleration;Acute;Affect;Alzheimer's Disease;analytical method;Animals;Area;Autoradiography;axon injury;Behavioral;Bioenergetics;Biological Assay;Blood - brain barrier anatomy;blood flow measurement;Blood Glucose;Brain;Brain Injuries;brain metabolism;Brain region;brain tissue;Cause of Death;Cerebrovascular Circulation;Cerebrum;Chemicals;Chronic;Clinical;Clinical Trials;clinically relevant;contrast enhanced;Data;design;Development;Diagnosis;Diffuse;Diffusion Magnetic Resonance Imaging;disability;Disease;efficacy evaluation;Energy Metabolism;Epilepsy;Event;Failure;Foundations;Functional disorder;Glucose;glucose metabolism;glucose monitor;Goals;Head;Human;Hypoxia;Image;Image Enhancement;Imaging Device;Immunohistochemistry;Impairment;improved;in vivo;Injury;Intervention;Lithium;Magnetic Resonance Imaging;Maps;Measures;Mechanics;Mental Depression;Metabolic;Metabolic Diseases;Metabolism;Methodology;Microdialysis;Modality;Modeling;Molecular;Mood stabilizers;Nerve Degeneration;Neurodegenerative Disorders;Neurologic;Neurological outcome;neurotransmission;neurotransmitter release;neurovascular;neurovascular coupling;Non-Invasive Detection;non-invasive imaging;non-invasive monitor;novel;Outcome;Pathology;Patients;Perfusion;personalized care;Pharmacotherapy;Phase;Positron-Emission Tomography;Process;Prognosis;prognostic indicator;Protons;Public Health;public health relevance;Publishing;Quality of life;Radioisotopes;Rattus;Recommendation;repaired;Resolution;Risk;Scheme;Sensitivity and Specificity;Severities;Signal Transduction;Source;Spectrum Analysis;TBI Patients;TBI treatment;Techniques;therapy development;Time;timeline;tissue injury;Tissues;tool;Tracer;Translating;Traumatic Brain Injury;treatment effect;Treatment Efficacy;treatment strategy;United States;United States Food and Drug Administration;Valproic Acid

PROJECT_TITLE: In vivo MRI Measures of Brain Metabolism in Traumatic Brain Injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Health Services;Kidney Disease;Pain Research;Patient Safety;Prevention;Urologic Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Preventive pharmacological therapy (PPT) for kidney stones is infrequently used due to gaps in the available evidence. Findings from our study will fill these gaps by providing data on clinically relevant outcomes, treatment tolerability, and potential healthcare savings. In doing so, our findings will help raise provider acceptance of and bolster guideline recommendations for PPT. To the extent that greater provider acceptance and more informed clinical practice guidelines increase the level of PPT use, patients with kidney stones will be the ultimate beneficiaries of our research.

PI_NAMEs: HOLLINGSWORTH, JOHN MALCOLM;SHAHINIAN, VAHAKN B (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Accident and Emergency department;Acute;Adult;Adverse event;Affect;Age;Alkalies;Allopurinol;American;beneficiary;Caring;Chemistry;Chronic Kidney Failure;Citrates;Clinical;Clinical Data;Clinical Management;Clinical Practice Guideline;clinically relevant;Collection;comorbidity;comparative effectiveness;cost;Data;Data Sources;data warehouse;demographics;Development;econometrics;economic implication;Effectiveness;Emergency department visit;Event;evidence base;Excision;Expenditure;experience;Facilities and Administrative Costs;Flank Pain;Funding Agency;Future;Guidelines;Health Care Costs;Health Personnel;Health Promotion;Healthcare;Healthcare Systems;Hospitalization;Hour;Image;innovation;inpatient service;Intervention;Kidney Calculi;Link;Longterm Follow-up;Measures;Medicare;Medicare claim;medication compliance;Observational Study;older adult;Operative Surgical Procedures;Outcome;outpatient programs;Pain;Patient risk;patient subsets;patient tolerability;Patients;payment;Pharmaceutical Preparations;Pharmaceutical Services;pharmacologic;Practice Guidelines;prevent;Prevention;Preventive;Procedures;Productivity;Professional Organizations;Provider;Randomized, Controlled Trials;Recommendation;Recurrence;relapse patients;Reporting;Research;Resources;Running;Sample Size;Savings;Source;Specific qualifier value;surgical service;System;systematic review;Techniques;thiazide;Thiazide Diuretics;treatment as usual;United States Agency for Healthcare Research and Quality;Urine;Veterans Health Administration;Work

PROJECT_TITLE: Real-world effectiveness of preventive pharmacological therapy for patients with kidney stones

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: Project Narrative ECoG is a critical methodological bridge between basic neuroscience findings and our understanding of the human brain in health and disease. However, adoption of ECoG for basic neuroscience, and realizing its full potentials in humans, is impeded by a lack of understanding of the precise biophysical processes generating cortical surface electrical potentials (CSEPs). We propose to use direct electrophysiological monitoring and optogenetic perturbations in rats and mice, combined with biophysically detailed simulations, to reveal the origins of distinct frequency components of ECoG- recorded CSEPs. We hypothesize that distinct CSEP components represent distinct cell types and laminar sources within a cortical column, and thus report different types of information in the local cortical network associated with these sources. This research will provide understanding of the cellular and biophysical origins of ECoG signals.

PI_NAMEs: BOUCHARD, KRISTOFER E. (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TITLE: Origins of ECoG

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Women's Health Research

PI_NAMEs: FAN, CHENGUANG  (contact)

PROJECT_TERMS: Address;Arkansas;Bacteria;Bioenergetics;Breast Cancer Cell;breast cancer diagnosis;Breast Cancer Patient;Breast Epithelial Cells;cancer cell;cancer therapy;Cancerous;Cell Proliferation;Cells;Citrate (si)-Synthase;Citric Acid Cycle;cofactor;Data;Data Analyses;data integration;Data Science;Data Science Core;Detection;Development;Diagnosis;Disease;Enzymes;experimental study;Generations;Genetic Code;Glutamates;Goals;Heterogeneity;Homeostasis;Homologous Gene;Human;Human Cell Line;Image;Individual;innovation;Investigation;Isocitrate Dehydrogenase;Kinetics;Knowledge;Link;Malate Dehydrogenase;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mentors;Metabolic;metabolic imaging;Metabolism;Methods;Molecular;Mutation;novel marker;Oncogenic;Oxidation-Reduction;Pathway Analysis;Pathway interactions;Phosphoamino Acids;phosphoproteomics;Phosphorylation;Phosphorylation Site;Phosphotransferases;Play;Production;Protein Isoforms;Protein Kinase;Proteins;Recombinants;repaired;Reporting;Research;Role;Signal Pathway;Site;Somatic Mutation;Spectrum Analysis;Structural Models;Structure;Substrate Specificity;System;Techniques;Testing;therapeutic target;Tissues;Variant;Woman;Women's Health;Work

PROJECT_TITLE: The role of phosphorylation of isocitrate dehydrogenase in breast cancer


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PISCATAWAY

ORG_DEPT: CHEMISTRY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Computational Enzymology to Study Diverse Catalytic Strategies of RNA PI: Darrin M. York, Rutgers University, Piscataway, NJ 08854-8087 USA. RNA enzymes are fundamental in biology, and have important applications for chemistry, biotech- nology and medicine. The goal of this proposal is to develop and apply a novel computational RNA enzymology approach to gain a predictive understanding of the diverse array of catalytic strate- gies exhibited by RNA enzymes. Powerful computational tools and insightful guiding principles for ribozyme engineering are likely to emerge that enable the design of new biomedical technology and therapeutics.

PI_NAMEs: YORK, DARRIN M (contact)

PROJECT_TERMS: Acids;Active Sites;Address;Adopted;Alkylation;Architecture;Automobile Driving;base;Binding;Biology;Biomedical Technology;Biotechnology;Catalysis;Catalytic DNA;Catalytic RNA;Chemicals;Chemistry;Communities;Computer software;computerized tools;Cryoelectron Microscopy;Crystallography;Data;deep learning;design;Devices;DNA;Engineering;Enzymatic Biochemistry;Enzymes;Equilibrium;Evaluation;Exhibits;Free Energy;Gene Expression;Goals;hammerhead ribozyme;Hepatitis Delta Virus;innovative technologies;insight;Introns;Isotopes;Kinetics;lead ion;Length;Machine Learning;Medicine;Metal Ion Binding;Metals;Methods;Methyltransferase;Modeling;Molecular Biology;molecular dynamics;molecular mechanics;new technology;novel;novel therapeutics;Nuclear;Nuclear Inclusion;Nucleic Acids;Pathway interactions;Play;programs;quantum;Quantum Mechanics;rational design;Reaction;RNA;RNA Computations;RNA Splicing;Role;scaffold;simulation;Site;Structure;Surface;System;Technology;Testing;Tetrahymena;Therapeutic;Thermodynamics;tool;Training;Transferase;Universities;Variant;Water


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Prevention

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Post-meal glucose control is challenging in individuals with type 1 diabetes, and it is associated with diabetes comorbidities. This project will assess the effect of dietary fat and protein on post- meal glucose control and examine if this information can be used in artificial pancreas systems in order to improve glucose control without meal announcement.

PI_NAMEs: EKHLASPOUR, LAYA  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: absorption;Address;Affect;Algorithms;Applications Grants;Artificial Pancreas;Blood Glucose;blood glucose regulation;Bolus Infusion;Carbohydrates;Caring;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;comorbidity;Continuous Glucose Monitor;Data;Data Set;Dedications;Development;diabetes management;Diabetes Mellitus;Dietary Fats;Dietary Proteins;Dose;experience;experimental study;Fatty acid glycerol esters;Food;Gastric Emptying;Gastroparesis;Glucose;glycemic control;Goals;Hour;Hyperglycemia;Hypoglycemia;improved;in silico;Individual;Insulin;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;Knowledge;Learning;Macronutrients Nutrition;Measures;Mentorship;Modeling;Nutrient;Observational Study;Patients;Pattern;Persons;predictive modeling;Process;Proteins;Pump;Randomized, Controlled Trials;rate of change;Reactive hypoglycemia;real time model;Research;Research Personnel;Research Training;response;risk mitigation;Structure;System;Time;Work

PROJECT_TITLE: Modeling and modulating insulin delivery in automated insulin delivery systems to accommodate for meal compositions

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Intracerebral hemorrhage is the most devastating form of stroke, with a mortality rate approaching 40% and with survivors suffering substantial disability. There are currently no proven treatments to limit neurologic injury after intracerebral hemorrhage, creating a critical need for new research into mechanisms of injury that can lead to novel therapeutic targets. Dr. Bevers’ career development plan has outstanding potential to further our understanding of the role of inflammation after brain hemorrhage and in doing so to bring the field closer to potential therapies.

PI_NAMEs: BEVERS, MATTHEW BRADFORD (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acute;adaptive immune response;Adaptor Signaling Protein;Admission activity;Anti-Inflammatory Agents;Binding;Biological Response Modifiers;blood product;Brain Edema;Brain hemorrhage;Brain Injuries;brain parenchyma;career;career development;cell injury;Cell Physiology;Cells;Cerebral Edema;Cerebral hemisphere hemorrhage;cerebrovascular;Clinical;clinical predictors;cohort;Complex;Critical Care;cytokine;Cytometry;Data Analyses;Death Rate;Deterioration;Development;Development Plans;disability;Edema;effective therapy;Effector Cell;Enrollment;Environment;Equilibrium;experience;follow-up;Functional disorder;functional outcomes;General Hospitals;Goals;healthy volunteer;Hematoma;Hemorrhage;Hospitals;Hour;Immune;Immune response;Immunology;improved;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Injury;Innate Immune Response;insight;Institution;Investigation;Laboratories;Link;Lobar;Location;Lymphocyte;Massachusetts;Measures;Mediating;Mediation;medical schools;Membrane;Mentors;Mentorship;Molecular Target;monocyte;mortality;multidimensional data;MyD88 protein;Natural Killer Cells;Nervous System Trauma;Neurologic;Neurological outcome;neurological recovery;Neurologist;Neurology;neurovascular injury;new therapeutic target;novel;novel therapeutics;Outcome;Pathway interactions;patient oriented research;Patients;Pattern;Peripheral;Peripheral Blood Mononuclear Cell;Population;predictive marker;prevent;prospective;Prospective cohort;Proteins;receptor;recruit;Regulation;Regulatory T-Lymphocyte;Research;Research Personnel;Research Project Grants;Resources;Role;Sampling;Scanning;secondary analysis;Secondary to;Signal Transduction;skills;standard of care;Stroke;Structure;Subarachnoid Hemorrhage;Survivors;System;T cell regulation;T-Lymphocyte;Tissues;TLR4 gene;Training;Universities;Water;Woman;X-Ray Computed Tomography

PROJECT_TITLE: Role of Soluble ST2 in Immune Cell Regulation and Secondary Neurologic Injury After Intracerebral Hemorrhage

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;HIV/AIDS;Infectious Diseases;Mental Health;Patient Safety;Precision Medicine;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Despite the remarkable success of combination antiretroviral therapy (cART) in reducing morbidity and mortality related to HIV disease, numerous studies have reported cART-related adverse effects on mental health including depression in people with HIV. Our proposed Bayesian statistical methods for understanding the longitudinal cART effects on depression and optimizing personalized sequential cART assignments will have substantial public health relevance in preventing increased likelihood of HIV transmission, and potential clinical utility by assisting physicians in making effective personalized treatment decisions and contributing to the ultimate goal of precision medicine in HIV.

PI_NAMEs: XU, YANXUN  (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: Address;Adverse effects;Age;Aging;antiretroviral therapy;Area;Bayesian Method;Bayesian Modeling;Behavioral;Caring;Central Nervous System;central nervous system injury;Characteristics;Chronic Disease;Clinical;clinical translation;combinatorial;comorbidity;Complex;complex data;Computational algorithm;Computer software;Data;data complexity;Data Set;Data Sources;demographics;Dimensions;Disease;Disease Outcome;Disease Progression;Drug Combinations;Drug Interactions;drug metabolism;efavirenz;Elderly;Encapsulated;FDA approved;Genetic;Genetic Polymorphism;Goals;Guidelines;Health;Health Care Costs;Heterogeneity;high dimensionality;HIV;HIV Infections;HIV therapy;improved;Individual;kernel methods;Knowledge;Laboratories;Learning;Link;Long-Term Effects;Longitudinal Studies;Mathematics;Measurement;Mediating;Mental Depression;Mental Health;Methods;model building;Modeling;Morbidity - disease rate;mortality;multiple data sources;National Institute of Mental Health;open source;Outcome;Pattern;personalized medicine;Persons;Pharmaceutical Preparations;Physicians;Population;practical application;precision medicine;Prevalence;prevent;Public Health;public health relevance;Recommendation;Recording of previous events;Reporting;Research;Risk;Selection for Treatments;Self Care;side effect;software development;Statistical Methods;Statistical Models;Structure;study population;success;Time;transmission process;treatment adherence;treatment choice;treatment planning;Trees;Uncertainty;United States Dept. of Health and Human Services;user-friendly;Viral;web app;Women's Interagency HIV Study

PROJECT_TITLE: Bayesian Methods for Optimizing Combination Antiretroviral Therapy for Mentalhealth in People with HIV

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Immunotherapy;Microbiome;Nutrition;Skin Cancer

ORG_CITY: FAYETTEVILLE

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

PI_NAMEs: RACINE MIOUSSE, ISABELLE  (contact)

PROJECT_TERMS: Adjuvant;Adopted;Affect;American;Animal Model;Antibodies;Arkansas;Autophagocytosis;Bacterial DNA;Bioenergetics;Body Weight;bone;Brain;cancer cell;Cells;Centers of Research Excellence;Cessation of life;checkpoint therapy;Clinical Trials;CTLA4 gene;Data;Data Analyses;data integration;Data Science;Development;Diet;dietary;dietary restriction;Disease;Disease remission;experimental study;Exposure to;fecal transplantation;Flow Cytometry;Germ-Free;Goals;Growth;gut microbiome;gut microbiota;Homocysteine;Image;Imaging Device;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunocompetent;improved;in vivo imaging;insight;ipilimumab;Literature;Liver;Lung;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Melanoma;Melanoma Tumor;Mentors;Metabolic;Metabolic Pathway;Metabolism;Metastatic Melanoma;Metastatic Neoplasm to the Lung;Methionine;Methylation;microbiome;microbiome alteration;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Monoclonal Antibodies;mortality;mouse model;Mus;Neoplasm Metastasis;Nivolumab;Normal Cell;novel strategies;novel therapeutic intervention;Pathway interactions;Patients;pembrolizumab;Persons;Population;pre-clinical;programmed cell death protein 1;Proteomics;Reactive Oxygen Species;repaired;Research;Research Personnel;Resistance;Resources;responders and non-responders;Role;Sampling;Source;Spectrum Analysis;standard of care;Testing;Therapeutic;Tissues;tumor;Tumor-Infiltrating Lymphocytes;Work

PROJECT_TITLE: Dietary methionine restriction as a therapeutic strategy for metastatic melanoma


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Eye Disease and Disorders of Vision;Genetics;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE. Pterygium is a fibrovascular growth of the conjunctiva that extends into the transparent cornea, causing a decline in vision. Ultraviolet exposure is an established risk factor for pterygium formation, but the exact molecular mechanism leading to pterygium progression is unknown. Here we will test the hypothesis that ultraviolet radiation induces activation of endogenous retroviruses, which are otherwise suppressed at basal conditions, and in turn promoting cell migration via non-canonical NF-κB signaling.

PI_NAMEs: BAKHOUM, MATHIEU FAHIM (contact)

PROJECT_TERMS: Astigmatism;Biological Markers;Cancer Model;Cell Line;cell motility;Cell Proliferation;Cells;Chronic;Clinical;clinical practice;Codon Nucleotides;conjunctiva;Conjunctival Pterygium;Cornea;Coupled;Data;Dependence;derepression;DNA;Double-Stranded RNA;Endogenous Retroviruses;Enzyme-Linked Immunosorbent Assay;Epithelium;Excision;experimental study;Eye;Fibroblasts;Genes;Genetic;genetic manipulation;Genetic Transcription;Goals;Growth;Human;Human Genome;Immunofluorescence Immunologic;Inflammation;Inflammatory Response;innate immune pathways;Intervention;irradiation;knock-down;Laboratories;Link;Mediating;Medical;migration;Molecular;Molecular Target;NF-kappa B;Nuclear;Obstruction;Operative Surgical Procedures;overexpression;Pathway interactions;pharmacologic;Phenotype;Play;Prevention;Principal Investigator;Production;professor;Proteins;Recurrence;Resources;Retroelements;Reverse Transcription;Risk;Risk Factors;RNA;RNA analysis;RNA-Directed DNA Polymerase;Role;Running;Sampling;sensor;Shapes;Signal Pathway;Signal Transduction;Skin;Specimen;Stimulator of Interferon Genes;Telomerase;Testing;Thinness;Transcriptional Activation;transcriptome sequencing;Ultraviolet B Radiation;Universities;Up-Regulation;UV induced;UV Radiation Exposure;vector;Viral;Vision;Visual;Western Blotting

PROJECT_TITLE: Identifying the molecular determinants of pterygium progression

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Genetics

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Public Health Narrative A better understanding of how mutations interact in combination to affect biological processes would improve our ability to predict the effect of genetic variation on health and disease, design proteins and cellular systems with desired functions, and target biological systems with chemical and genetic therapies. New technologies have been developed to measure the effects of large numbers of mutations, singly and in combination, on biochemical properties, but they have never been applied to understand the effects on fitness of the specific set of mutations that have actually occurred in real proteins during real evolutionary processes. Here we combine those technologies with methods to reconstruct the evolutionary history of genes and proteins to reveal the historical effects and interactions among all mutations that occurred over a billion- year long trajectory in the biologically essential protein Hsp90, which helps hundreds of client proteins in the cells of humans and other species fold and function and plays crucial roles in many disorders and diseases.

PI_NAMEs: BOLON, DANIEL N;THORNTON, JOSEPH W (contact)

PROJECT_TERMS: Accidents;Affect;Amino Acid Sequence;Amino Acids;Animals;Architecture;Biochemical;Biological Assay;Biological Models;Biological Process;biological systems;Biophysical Process;biophysical properties;Biophysics;Catalysis;Cells;Chemicals;Client;Conserved Sequence;Data;Disease;Engineering;Enzymes;Eukaryota;Eukaryotic Cell;Event;Evolution;experimental analysis;experimental study;fitness;fungus;Future;gene therapy;Genes;Genetic;Genetic Epistasis;Genetic Variation;Health;Human;improved;insight;Knowledge;Lead;Libraries;Ligand Binding;Measures;Mediating;Methods;Molecular Chaperones;Molecular Conformation;Molecular Evolution;mutant;Mutation;mutation screening;new technology;Outcome;Pattern;Phylogenetic Analysis;Phylogeny;Play;prevent;Process;Property;Protein Engineering;protein folding;Proteins;Public Health;reconstruction;Recording of previous events;Resolution;Role;Saccharomyces cerevisiae;sample fixation;Sampling;Shapes;Signal Transduction;Site;Structure;Structure-Activity Relationship;System;Techniques;Technology;Time;tool;Work;Yeasts

PROJECT_TITLE: Comprehensive analysis of fitness effects and epistasis along a billion-year evolutionary trajectory

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Dissemination and Implementation Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Stroke

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Based on the success of trauma systems, the Alabama Department of Public Health is planning a five-year statewide quality improvement initiative of trauma communications center coordinated stroke triage which aims to transform the fragmented acute stroke care system by coordinating prehospital and inter-facility emergency stroke care. This allows assessment of both the public health impact and the “how and why” of implementation of an innovative acute stroke care model that will aid in future implementation efforts. This project, if successful, can serve as a model for how the trauma system infrastructure that already exists in other regions and states can serve as the basis for a more integrated and effective system of emergency stroke care throughout the US.

PI_NAMEs: GROPEN, TOBY  (contact)

PROGRAM_OFFICER_NAME: JANIS, SCOTT

PROJECT_TERMS: access disparities;Acute;acute stroke;Address;Adoption;Alabama;care systems;Caring;cluster trial;Collaborations;Communication;Data Collection;design;Development;Dimensions;Effectiveness;Effectiveness of Interventions;effectiveness/implementation study;Emergency medical service;Emergency Situation;Equity;Ethnic Origin;Focus Groups;future implementation;Geographic Locations;Goals;Health;Hospitals;Human Resources;Hybrids;implementation efforts;implementation fidelity;improved;improved outcome;Infrastructure;injured;innovation;Intervention;Interview;Ischemic Stroke;Maintenance;Mechanics;Methods;Minority;Modeling;Natural experiment;novel;Outcome;Patient-Focused Outcomes;Patients;Perception;Phase;Population Density;Process;Public Health;Qualitative Methods;Race;racial difference;Reach, Effectiveness, Adoption, Implementation, and Maintenance;rural disparities;severe injury;Severities;socioeconomic disparity;Stroke;success;Surveys;System;Thrombectomy;Training;Trauma;Triage

PROJECT_TITLE: Trauma Communications Center Coordinated Severity-Based Stroke Triage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DIRH-N(09)]


ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Cell division is crucial for life but can also threaten life by causing overproliferation as it does in cancer. The goal of this project is to understand how proteins that drive cell division are produced and how this affects their function. This will help to understand how cell division can go awry and may provide new entry points for blocking uncontrolled division.

PI_NAMEs: HAUF, SILKE  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Affect;Automobile Driving;cancer genetics;cdc Genes;Cell Cycle;Cell Cycle Proteins;Cell Cycle Regulation;Cell division;Cell Physiology;Cells;DNA;feature selection;Fission Yeast;Genes;Genetic Diseases;Genome;Goals;Growth;Human;insight;Life;Link;Malignant Neoplasms;Messenger RNA;model organism;Mutation;Other Genetics;Pathway interactions;precision medicine;Process;Production;Proliferating;protein function;Proteins;Supporting Cell;System;Untranslated RNA;Work

PROJECT_TITLE: How mRNA features of cell cycle genes support proper cell division

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed UCSF-UCB TRAC Center will unite and expand the tuberculosis (TB) research programs of UCSF and UCB to accelerate discovery and to develop new ways to detect, prevent and treat TB infection in humans. By creating a program that helps new researchers navigate the unique difficulties of working on this formidable pathogen and that fosters multidisciplinary collaborations, we envision this Center will increase the vibrancy of TB research in the Bay Area and beyond.

PI_NAMEs: COX, JEFFERY S;NAHID, PAYAM  (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Acceleration;Address;Affect;Area;Award;Basic Science;Biomedical Research;career;career development;Clinical;Clinical Research;Clinical Sciences;cohort;Collaborations;Communication;Communities;community advisory board;community center;community engagement;Complex;Conceptions;Consultations;Country;Data;data management;Dedications;design;Development;Diagnosis;Diagnostic;Discipline;Doctor of Philosophy;Education;Environment;Epidemic;Equity;experience;experimental study;Faculty;flexibility;forging;Fostering;Funding;Future;Goals;Health Sciences;Human;human subject;improved;Income;Infrastructure;innovation;interdisciplinary collaboration;Interdisciplinary Study;International;international partnership;Intervention;Investigation;Laboratories;Laboratory Research;Lead;Leadership;member;Mentors;Mentorship;mobile computing;multidisciplinary;Mycobacterium tuberculosis;next generation;operation;pathogen;Peer Review;Peer Review Grants;Population Sciences;Positioning Attribute;prevent;Prevention;Productivity;Program Development;programs;Research;Research Design;Research Personnel;Resources;Sampling;San Francisco;Scientist;Services;Site;success;System;Technical Expertise;Technology;tool;Training;Training Programs;Tuberculosis;tuberculosis treatment;United States National Institutes of Health;Vaccines;voucher

PROJECT_TITLE: UCSF-UCB Tuberculosis Research Advancement Center (TRAC)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases;Tuberculosis

PI_NAMEs: NAHID, PAYAM  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Administrative Coordination;Advisory Committees;Advocacy;Area;Binding;career;career development;civil society;Clinical;Collaborations;Communication;Communities;community advisory board;community center;community engagement;Consultations;Decision Making;design;Development;Doctor of Philosophy;Ensure;Evaluation;expectation;Extramural Activities;Funding;Goals;Grant;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;International;Leadership;member;Mentors;Mentorship;Mission;Modeling;Modification;Monitor;multidisciplinary;National Institute of Allergy and Infectious Disease;Nerve;Occupational activity of managing finances;operation;organizational structure;Performance;Pilot Projects;Process;programs;Publications;Research;Research Activity;Research Personnel;research study;Resources;Running;Services;sound;Strategic Planning;Structure;Supervision;Survivors;symposium;timeline;Tuberculosis;virtual

PROJECT_TITLE: UCSF-UCB TRAC ADMININSTRATIVE CORE


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Genetics;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Infectious Diseases;Lung;Pediatric;Pneumonia;Pneumonia and Influenza;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The proposed research project will improve public health by advancing our understanding of the impact of cooking-related household air pollution exposure during pregnancy and childhood on lung health development. We will also investigate whether some people are especially susceptible to household air pollution. This will help inform cost-effective policies to protect children during this critical window of susceptibility.

PI_NAMEs: JACK, DARBY  (contact);LEE, ALISON G

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: 1 year old;13 year old;8 year old;Acute;Affect;Age;Air Pollution;airway epithelium;Anthropometry;arm;attributable mortality;Biological;Birth;Blood;blood pressure reduction;Breathing;Carbon Monoxide;cell age;Cell Line;Cells;Cessation of life;Charcoal;Child;Childhood;Chronic Disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;cohort;Cohort Studies;comparison control;cooking;Cookstove;cost effective;cost effective intervention;data repository;Development;disability-adjusted life years;disorder risk;early childhood;Early Intervention;Effectiveness of Interventions;Epithelial Cells;evidence base;Exhibits;Exposure to;fine particles;Fire - disasters;follow-up;Funding;Future;Gases;Gene Expression;Genetic Polymorphism;Genotype;Ghana;Glycoproteins;Growth;Health;Heterogeneity;Household;Household Air Pollution;Human;Hypertension;Impairment;improved;Individual;infancy;Infant;Intention;Intervention;intervention effect;Investments;Life;Life Cycle Stages;Link;low and middle-income countries;Lower Respiratory Tract Infection;Luciferases;lung development;Lung Diseases;lung health;lung preservation;Measures;Messenger RNA;Methods;mRNA Expression;MUC5AC gene;MUC5B gene;Mucins;Mucous body substance;Mus;Mutation;Nasal Epithelium;Outcome;Outcome Assessment;Participant;Persons;Petroleum;Phenotype;Pneumonia;Policies;Predisposition;Pregnancy;Pregnant Women;prenatal;programs;promoter;Public Health;pulmonary function;Randomized;Reporter Genes;repository;Research;Research Project Grants;Respiratory Disease;Respiratory Signs and Symptoms;response;Risk;Risk Reduction;Signal Pathway;Single Nucleotide Polymorphism;Site;Smoke;smoke-induced lung disease;Source;Spirometry;Spottings;Streptococcus pneumoniae;TP53 gene;transcription factor;Transfection;Variant;Wild Type Mouse;Wood material;wood smoke

PROJECT_TITLE: Child Lung Development Following a Cookstove Intervention: Evidence from GRAPHS

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


PI_NAMEs: FAIR, ELIZABETH  (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Area;Award;career;career development;Collaborations;Community of Practice;Country;Development;Discipline;Doctor of Philosophy;Educational workshop;Equity;equity, diversity, and inclusion;Evaluation;Faculty;Feedback;Fostering;Funding;Funding Opportunities;Future;global health;Goals;Grant;Income;Individual;Inequity;innovation;instrument;interdisciplinary collaboration;Interdisciplinary Study;International;international partnership;Leadership;lectures;Link;meetings;member;Mentors;Mentorship;Methods;multidisciplinary;next generation;Outcome;Peer Review;Program Development;programs;Research;research and development;Research Personnel;Resource Allocation;Resources;response;Science;Scientist;Series;Services;Site;skills;Structure;success;tool;Training;Tuberculosis;Vision;Writing

PROJECT_TITLE: UCSF - UCB TRAC Developmental Core


PI_NAMEs: SHETE, PRIYA B. (contact)

PROJECT_TERMS: Acceleration;Affect;Area;Basic Science;bench-to-bedside translation;Bioinformatics;Biological;Biomedical Research;Biometry;career development;Caring;Clinical;clinical center;Clinical Research;clinical research site;Clinical Sciences;cohort;Collaborations;Communities;community advisory board;community center;community engagement;Conceptions;Consultations;cost;COVID-19 pandemic;Data;data management;Data Science;Data Set;Databases;design;Development;Discipline;Disease;Dissemination and Implementation;Doctor of Philosophy;Ecosystem;Epidemiology;Equity;Evaluation;experience;Faculty;Feedback;Fostering;Generations;Goals;Health Status;Human;Human Subject Research;improved;Incidence;Individual;Infrastructure;Infusion procedures;innovation;interdisciplinary approach;International;Intervention Trial;Investigation;Link;meetings;Mentors;Mentorship;Methodology;Methods;mortality;multidisciplinary;novel;Outcome;pandemic disease;Participant;population health;Population Sciences;Populations at Risk;Prevention;programs;Prospective, cohort study;Public Health;repository;Research;Research Design;Research Methodology;Research Personnel;research study;Resources;Risk;scale up;Scientist;searchable database;Services;Social Sciences;Source;Specimen;Statistical Data Interpretation;tool;Training;translational study;Tuberculosis

PROJECT_TITLE: UCSF-UCB TRAC Clinical Sciences Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

PI_NAMEs: JAVID, BABAK  (contact)

PROJECT_TERMS: Acceleration;Address;Animals;Antibiotics;Award;Basic Science;Biomedical Research;biosafety level 3 facility;career;career development;Clinical;clinical center;Clinical Research;clinical research site;Clinical Sciences;Collaborations;combat;Communities;Conceptions;Consultations;Data;Data Analyses;design;Development;Development Plans;Diagnosis;Discipline;Disease;Doctor of Philosophy;Educational workshop;Engineering;Epidemic;Evaluation;experimental study;Face;Faculty;Feedback;Fostering;Funding Mechanisms;Funding Opportunities;Goals;graduate student;high reward;high risk;Human;Human Resources;Immune response;Immunity;Individual;Infectious Agent;Infrastructure;Infusion procedures;innovation;interdisciplinary approach;Interdisciplinary Study;International;Investigation;Investments;Knowledge;Laboratories;Manpower and Training;Mentors;Mentorship;method development;Methods;Modeling;multidisciplinary;Mycobacterium tuberculosis;new technology;next generation;novel;novel therapeutic intervention;novel vaccines;Nursing Faculty;pandemic disease;pathogen;Pathogenesis;Postdoctoral Fellow;prevent;Probability;programs;Protocols documentation;Research;Research Design;research faculty;Research Personnel;Research Training;Resources;Scientist;Services;Site;Technology;Testing;Time;tool;Training;Tuberculosis;tuberculosis treatment;Vaccines;voucher;Work

PROJECT_TITLE: UCSF - UCB TRAC Basic Science CORE