NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: The lack of effective treatment against metastatic cancer is primarily due to the complexity of the disease and incomplete understanding of the key mechanisms. We address this challenge through an unconventional approach that takes advantage of a specific feature of cancer cells distinguishing them from normal cells. We use this unique feature to develop anti-cancer drugs for discovery of agents selective against cancer cells over normal cells. We have developed a clinical candidate (metarrestin) that shows selective inhibition of cancer metastasis in animals. Metarrestin has begun a phase I pancreatic cancer clinical trial at NCI. We will investigate how this compound inhibits cancer behavior and will develop next generation, more specific and potent anti- cancer drugs.

PI_NAMEs: FRANKOWSKI, KEVIN J.;HUANG, SUI  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Address;Adverse effects;analog;Animals;anti-cancer;Antineoplastic Agents;Behavior;Binding;Biological Availability;cancer biomarkers;cancer cell;Cancer cell line;cancer clinical trial;cancer survival;carcinogenesis;Cause of Death;Cell Line;Cells;Cessation of life;Characteristics;Chemicals;Clinic;clinical candidate;clinical practice;Complex;counterscreen;Cytology;cytotoxicity;Development;Disease;Disease Progression;Disseminated Malignant Neoplasm;DNA Binding;drug development;drug discovery;Drug Kinetics;effective therapy;Evaluation;Event;Exhibits;experimental study;gene product;Genes;Goals;Growth;high throughput screening;human cancer mouse model;improved;In Vitro;in vitro Assay;in vivo;inhibitor;Invaded;Knowledge;Libraries;Liver;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Metastasis Induction;Metastatic breast cancer;Metastatic Neoplasm to the Lung;migration;Modeling;Molecular Target;Morphology;Mus;Nature;Neoplasm Metastasis;neoplastic cell;next generation;Normal Cell;novel;novel therapeutics;Nuclear;Nude Mice;Oncogenic;Oral;pancreas xenograft;Pathway interactions;Patient-Focused Outcomes;Patients;Phase;Phase I Clinical Trials;Phenotype;phenotypic biomarker;pre-clinical;Prevalence;Primary Neoplasm;Process;Productivity;prognostic;Property;Proteins;Reducing Agents;Ribosomes;Role;scaffold;screening;small molecule;Structure;Surrogate Markers;targeted agent;Therapeutic;Tissues;tool;Toxic effect;tumor;tumor growth;Tumor Tissue;United States National Institutes of Health;Validation;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Phenotypic marker-guided development of selective antimetastasis therapeutic leads

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NUTRITION

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative State-of-the-art technology for simultaneously isolating and measuring the number and size of high density lipoprotein particles in clinical samples will be developed and validated using gold-standard methods.

PI_NAMEs: ZIVKOVIC, ANGELA M (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Activities of Daily Living;Acute Disease;acute infection;Address;Affinity;Age;Antioxidants;Apolipoprotein A-I;Apolipoproteins;Behavior;Binding;Biological;Biology;Biomedical Research;blood-brain barrier crossing;Cardiovascular Diseases;Characteristics;Chemicals;Cholesterol Esters;Chronic;Chronic Disease;Clinical;Communities;Complex;Coupled;Data;detector;Development;Diagnostic;Diameter;Disease;Ethnic Origin;Excision;Exclusion;experimental study;Exposure to;Fractionation;gel electrophoresis;Glucose;glycation;glycosylation;Health;Heterogeneity;High Density Lipoproteins;High Pressure Liquid Chromatography;immunoregulation;improved;In Vitro;Individual;innovation;instrument;instrumentation;Knowledge;light scattering;Lipids;Lipoprotein (a);Lipoproteins;Longevity;Mass Spectrum Analysis;Measurement;Measures;Mediator;men;Metabolic Clearance Rate;Methods;Mission;Modification;Molecular;Molecular Sieve Chromatography;mortality;Names;National Institute of General Medical Sciences;Nature;Nerve Degeneration;new technology;Nuclear Magnetic Resonance;Optics;Oxidants;oxidation;particle;Particle Size;Performance;Physiological;Plasma;Polysaccharides;Protein Analysis;Proteins;Publishing;receptor;reconstitution;Refractive Indices;Research;Research Personnel;Sampling;Sepsis;Series;Signal Transduction;Structure;System;Technology;theories;Therapeutic;therapeutically effective;Transmission Electron Microscopy;Validation;Woman

PROJECT_TITLE: Development of a Novel Technology for Preparative Fractionation and Characterization of Lipoprotein Particles

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Aortic stenosis is a common disease of the elderly that is caused by narrowing of the heart valve through which the heart pumps blood to the body, and can result in cardiac failure and death. All attempts at medical therapy to slow disease progression have failed, resulting in surgery being the only treatment for aortic stenosis. We will apply advanced imaging in animal models and humans to investigate a potentially treatable cause of aortic stenosis that involves blood platelets attaching to the aortic valve leaflets, thereby triggering adverse valve thickening.

PI_NAMEs: LINDNER, JONATHAN R (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Acceleration;acetovanillone;Acetylcysteine;ADAMTS;Adhesions;Affect;Age;Age Years;aggressive therapy;Animal Model;Animals;Antioxidants;Aorta;aortic valve;aortic valve replacement;Aortic Valve Stenosis;Arteriogram;Atherosclerosis;Binding;Biology;Blood;Blood Platelets;blood pump;Blood Vessels;calcification;Cardiac Death;Cell Proliferation;cell transformation;Clinical Trials;contrast enhanced;Country;cytokine;Data;Dependence;Development;Disease;Disease Progression;Doppler Echocardiography;Doppler Ultrasound;Echocardiography;Elderly;electric impedance;Endothelial Cells;Endothelium;Evaluation;Event;extracellular vesicles;Generations;Goals;Growth Factor;Guidelines;Health Expenditures;Heart;Heart failure;Heart Valves;hemodynamics;high risk;Histologic;Histology;Human;human old age (65+);hypertension treatment;Image;in vivo;indexing;Inflammatory;inhibitor;interstitial cell;Intervention;Investigation;Left;Left Ventricular Function;Left Ventricular Hypertrophy;Left Ventricular Mass;Left Ventricular Remodeling;Ligands;Longitudinal Studies;Low-Density Lipoproteins;Mediating;Mediator;Medical;Methods;Modeling;Molecular Conformation;molecular imaging;mouse model;Mus;non-compliance;non-invasive imaging;noninvasive diagnosis;novel;Operative Surgical Procedures;osteogenic;paracrine;Pathway interactions;Patients;Pattern;PDGFA gene;Peptide Hydrolases;pharmacologic;Phenotype;Plasma;Platelet-Derived Growth Factor;Population;Predictive Factor;prevent;Procedures;Process;Proliferating;prospective;Proteolysis;RANTES;Reactive Oxygen Species;Recombinants;recruit;Research;Resistance;Resources;Sclerosis;Secondary to;Signal Pathway;Signal Transduction;Signaling Molecule;Surface;Systems Biology;Techniques;Testing;therapeutic target;Tissues;transcriptomics;ultrasound;valve replacement;Ventricular;von Willebrand Factor;Wild Type Mouse

PROJECT_TITLE: Advanced Non-invasive Imaging in the Investigation of Aortic Stenosis Pathobiology

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Despite the critical nature of cocaine addiction, current preclinical models devoted to investigating the enduring neural substrates of cocaine addiction have yielded little insight into developing novel treatment targets. In this application, we focus on distinct, time-dependent interventions during abstinence from cocaine self-administration in male and female rats to normalize cocaine-induced dysfunction in the prefrontal cortex thereby decreasing persistent cocaine-seeking. These studies will impact the field of drug abuse research by advancing our understanding of the key neurobiological substrates that mediate relapse to drug-seeking with the potential of leading to possible novel therapeutic targets for men and women suffering from substance use disorders.

PI_NAMEs: MCGINTY, JACQUELINE F. (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Abstinence;addiction;Anxiety;anxiety reduction;anxiety-related behavior;Brain-Derived Neurotrophic Factor;Cocaine;Cocaine Dependence;cocaine seeking;cocaine self-administration;combinatorial;Coupled;CREB1 gene;Cue-induced relapse;Cues;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Dendritic Spines;designer receptors exclusively activated by designer drugs;Diameter;Drug abuse;Early Intervention;effective therapy;Electrophysiology (science);Environment;Extracellular Signal Regulated Kinases;Female;Functional disorder;Future;genetic approach;Genetic study;Glutamates;Head;Image;Individual;Infusion procedures;insight;Intervention;male;Mediating;men;Nature;neural;neuroadaptation;Neurobiology;Neurons;new therapeutic target;novel;Pathway interactions;Performance;Pharmaceutical Preparations;Phase;phase change;Phosphorylation;pre-clinical;Pre-Clinical Model;Prefrontal Cortex;prevent;Protein Dephosphorylation;Protein Kinase A Inhibitor;Proteins;Rattus;Regulation;Relapse;Research;retrograde transport;Rewards;Role;Signal Transduction;Slice;Structure of paraventricular nucleus of thalamus;Substance Use Disorder;Synaptic plasticity;Testing;Time;transmission process;Viral Vector;Withdrawal;withdrawal-induced anxiety;Woman

PROJECT_TITLE: Pathway-specific Intervention in Prelimbic Cortical Circuitry Decreases Cocaine-seeking

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Neurosciences;Prevention;Vaccine Related

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PI_NAMEs: COX, MAUREEN  (contact)

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;adaptive immunity;Adrenergic Agents;afferent nerve;Anti-Bacterial Agents;Antibiotics;Antibodies;Antibody Response;Antigens;Attenuated;Awareness;B-Cell Development;B-Lymphocytes;Bacterial Antibodies;cell injury;Cells;Chemicals;Clostridioides difficile vaccine;Clostridium difficile;Collaborations;Colon;Communication;Critical Pathways;desensitization;Development;Enteral;Exotoxins;Failure;Functional disorder;Generations;Human;Humoral Immunities;Immune;Immune Evasion;immune function;Immune response;Immunity;Immunoglobulin G;Immunoglobulin M;Impairment;Infection;Inflammatory Bowel Diseases;Injections;Intestines;Laboratories;lymph nodes;lymphoid organ;Measures;Memory;Memory B-Lymphocyte;mouse model;Mus;Nerve;nerve supply;Nervous System;Nervous System control;neuron loss;Neurons;Neuropeptides;neurotransmission;neurotransmitter release;neutralizing antibody;Nosocomial Infections;Organism;pathogen;Pathology;Patients;Predisposition;prevent;programs;Proton Pump Inhibitors;Rattus;Recurrence;recurrent infection;response;rho GTP-Binding Proteins;Risk Factors;Role;Signal Transduction;Site;Spleen;Staphylococcus aureus infection;T-Lymphocyte;Testing;Toxic effect;TRPV1 gene;Vaccination;vaccine immunogenicity;Work

PROJECT_TITLE: Nervous system control of immunity to C. difficile


ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative  Immunotherapy related adverse events (irAE), especially the irAE associated with combination of anti- CTLA4 and anti-PD1/PD-L1, are serious clinical problems that affect the cancer treatment efficacy and compliance, as well as patients' quality of life. Our hypothesis is reduction of cell surface and soluble CTLA4 by anti-CTLA-4 antibodies may contribute to irAE. Our work will not only establish a fundamental mechanism of irAE but also a treatment for adverse effect associated with anti-PD-1 and anti-CTLA-4 combination therapy.

PI_NAMEs: SU, LISHAN  (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Ablation;Address;Adverse effects;Adverse event;Affect;Alternative Splicing;anti-CTLA4;anti-CTLA4 antibodies;anti-PD-1;Antibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;Binding;cancer immunotherapeutics;cancer immunotherapy;Cancer Patient;cancer therapy;Cell surface;Clinic;Clinical;Combined Modality Therapy;CTLA4 gene;CTLA4-Ig;Data;effective therapy;Engineering;Exhibits;Experimental Models;Foundations;Genetic;Human;immune checkpoint;Immune checkpoint inhibitor;Immune Targeting;Immunologics;Immunooncology;Immunotherapy;in vivo;interest;ipilimumab;Knock-in;Link;Malignant neoplasm of lung;Malignant Neoplasms;Marketing;Mediating;Melanoma;Melanoma patient;Membrane;Modeling;Molecular;Monoclonal Antibodies;mouse model;Mus;mutant;novel;Pathogenesis;Patients;PD-1/PD-L1;Pre-Clinical Model;preservation;prevent;Prevention;programmed cell death protein 1;prophylactic;Proteins;Publishing;Quality of life;Recycling;Regulatory T-Lymphocyte;Research;Research Personnel;Role;Severities;Testing;Therapeutic;Therapeutic Effect;therapy adverse effect;Toxic effect;treatment adherence;Treatment Efficacy;Tumor Immunity;tumor microenvironment;Work

PROJECT_TITLE: Preserving CTLA-4 immune checkpoint for safer and more effective cancer immunotherapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: WORCESTER

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Both HIV and Mycobacterium tuberculosis (Mtb) establish life-long infections that, despite the development of antiretroviral therapy and antibiotics, cause millions of deaths every year, emphasizing the need to develop a cure. This proposal aims to define the methods by which HIV and Mtb evade immune-mediated clearance by characterizing their common target cell, the macrophage, and how this cell acts to shield these pathogens from immune responses. Insight into these mechanisms will help identify macrophage-specific pathways that can be exploited to make these infected cells more susceptible to immune-mediated clearance, potentiating the development of cure-based strategies for HIV and Mtb infection.

PI_NAMEs: CLAYTON, KIERA L. (contact)

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Anti-Retroviral Agents;Antibiotics;antigen-specific T cells;Antigens;antiretroviral therapy;Apoptosis;Area;Award;Candidate Disease Gene;Cardiovascular Diseases;Caspase;CD4 Positive T Lymphocytes;CD94 Antigen;Cell Communication;Cell Death;cell killing;cell type;Cells;Cessation of life;Characteristics;Chronic;comorbidity;cytokine;Cytomegalovirus;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;design;Development;Doctor of Philosophy;Exhibits;Failure;Future;Gene Expression Profile;Goals;Granzyme;HIV;HIV Infections;HIV/TB;Human;Immune;Immune Evasion;Immune response;Immunity;Immunology;Individual;Induction of Apoptosis;Infection;Inflammation;inhibitor;innovation;insight;Knock-out;Laboratories;Ligands;Liver diseases;Macrophage;Mediating;Methods;Mission;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;Natural Killer Cells;Nature;neutralizing antibody;pathogen;Pathway interactions;Penetrance;Pharmaceutical Preparations;Postdoctoral Fellow;Predisposition;prevent;Productivity;programs;Proteins;Publishing;Research;Resistance;response;side effect;Supervision;systemic inflammatory response;T cell response;T-Lymphocyte;T-Lymphocyte and Natural Killer Cell;therapeutic development;therapy design;therapy development;Tissues;Tuberculosis;Viral;virological synapse;virology;Virus;Work

PROJECT_TITLE: Characterizing Macrophages as "Hide-Outs" for Chronic Pathogens


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention

ORG_CITY: DAYTON

ORG_NAME: DAYTON CLINICAL ONCOLOGY PROGRAM

ORG_STATE: OH

PHR: Dayton Clinical Oncology Program (Dayton NCORP) Project Narrative:  Since 1982, the Dayton Clinical Oncology Program has been fundamental in increasing access to  NCI  clinical  trials  to  patients  in  communities  throughout  Ohio  and  Indiana.  Patients  have  the  opportunity  to  participate  in  treatment,  cancer  control  and  prevention  studies,  along  with  Cancer  Care  Delivery  Research  (CCDR)  without  leaving  their  communities.  This  provides  significant contributions to further development in cancer care.

PI_NAMEs: GROSS, HOWARD M (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Accounting;Address;Adult;Affect;Aftercare;Agreement;anti-cancer research;Area;Automobile Driving;Award;base;Budgets;Bylaw;cancer care;cancer clinical trial;Cancer Control;cancer prevention;cancer therapy;care delivery;Caring;Chairperson;Clinical Oncology;Clinical Trials;Communities;Community Clinical Oncology Program;Community Networks;community organizations;community research;community setting;comorbidity;Consent;Contracts;Data;design;Development;Disparity;Doctor of Medicine;Ensure;Financial Audit;Funding;Genomics;Goals;Governing Board;Grant;Gynecologic Oncology;Health Service Area;Healthcare Systems;Hospitals;Human Resources;improved;Incidence;Indiana;Infrastructure;Institution;interest;Intervention Studies;Longitudinal Studies;Malignant Neoplasms;Medical;Medical center;member;Minority;Mission;Modeling;mortality;multimodality;Nursing Research;Observation in research;Observational Study;Ohio;Oncology;oncology program;Operative Surgical Procedures;patient navigation;Patient-Focused Outcomes;Patients;Pattern;Pharmacy facility;Physicians;Population;Postdoctoral Fellow;Prevention;Principal Investigator;Process;programs;Protocols documentation;Quality of life;Radiation therapy;Reporting;Research;Research Project Grants;Running;screening;Services;Site;social factors;Specialist;team-based care;Time;treatment trial;Underserved Population;Universities;Woman

PROJECT_TITLE: Dayton Clinical Oncology Program


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: RIVERSIDE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Scanning plays a crucial role in defining and maintaining the integrity of the proteome, but it remains one of the least-well understood components of regulated protein synthesis. By directly observing scanning dynamics on single messenger RNAs, we will establish a quantitative molecular mechanistic framework that deepens our understanding of scanning and aids efforts to understand and reverse how it is dysregulated in disease.

PI_NAMEs: O'LEARY, SEAN E (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 5' Untranslated Regions;Address;Agreement;Area;base;Base Sequence;Behavior;Binding;Biochemical;Biological Assay;Biophysics;Cells;Chemicals;cofactor;Complement;Complex;Data;defined contribution;design;developmental disease;Disease;eIF-4B;Ensure;Eukaryota;Event;experimental study;extracellular;Failure;flexibility;Fluorescence;Genetic;Health;Heart;helicase;in vivo;Initiator Codon;insight;Length;Life;Location;Malignant Neoplasms;Measures;Messenger RNA;Methods;Modeling;Molecular;Motion;Nucleotides;Open Reading Frames;Outcome;Peptide Initiation Factors;Phase;Play;Positioning Attribute;Process;Property;Protein Biosynthesis;Proteins;Proteome;Reagent;reconstitution;Refractory;Regulation;Resolution;response;Ribosomes;RNA Helicase;Role;Saccharomyces cerevisiae;Scanning;single molecule;Site;Stimulus;Stress;Structure;synthetic biology;therapeutic development;Time;transcriptome;Translating;Translation Initiation;Translations;Virus Diseases;Visualization;Yeasts

PROJECT_TITLE: Dynamics of Eukaryotic Ribosomal Scanning

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS BOSTON

PHR: PROJECT NARRATIVE Our work will use quantitative and systems biology approaches for analyzing the regulation and function of the Extracellular Signal-Regulated Kinase (ERK) signaling pathway that plays a key role in human and animal development and disease. We focus on the transcriptional interpretation of ERK signals by Capicua (Cic) and other regulators, and will develop an integrated mathematical model for the control of gastrulation, a critical developmental event. Alterations of the ERK signaling pathway in humans are involved in a range of disorders, including Rasopathies, cancer, neurodegenerative diseases, and the autism spectrum disorder (ASD).

PI_NAMEs: VERAKSA, ALEXEY  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Acute;Address;Animals;autism spectrum disorder;Biochemical;Biological;Biological Assay;cancer type;Cells;cohort;Computer Models;Data;data-driven model;design;Development;Developmental Biology;Developmental Process;Disease;DNA Binding;Down-Regulation;Drosophila genus;Embryo;Essential Genes;Event;Experimental Models;Extracellular Signal Regulated Kinases;gastrulation;Gene Expression Regulation;gene repression;Genetic;Genetic study;Genetic Transcription;Goals;Human;human disease;Image;in vivo;in vivo evaluation;insight;Malignant Neoplasms;mathematical model;Mesoderm;Modeling;Molecular;Nature;neurocognitive disorder;Neurodegenerative Disorders;novel strategies;Nuclear;optogenetics;Organ Size;Pathologic;Pathway interactions;Pattern;phosphoproteomics;Phosphorylation Site;Play;Process;Proteins;Regulation;Repression;Research;response;Role;sensor;Signal Pathway;Signal Transduction;Site;System;Systems Biology;Testing;Time;Tissues;Transcription Repressor;Work

PROJECT_TITLE: Mechanisms of signal integration in developmental control of organ size and tissue patterning

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Genetics;Nanotechnology;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE Nanomedicines are playing an increasing role in delivery of cancer therapeutics, however, variability in treatment response significantly limits their effectiveness and clinical translation. To address this shortcoming a nanoparticle-based molecular imaging agent will be developed as a companion diagnostic to visualize the delivery of a new therapeutic nanomedicine for prostate cancer. This agent may be used in the future in men with prostate cancer to select those patients that may benefit from the new nanomedicine.

PI_NAMEs: AGGARWAL, RAHUL ;FLAVELL, ROBERT RICHARD;VANBROCKLIN, HENRY F. (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Address;androgen independent prostate cancer;Animal Model;arm;Biodistribution;Biological Markers;Cancer Model;Cancer Patient;Cell Line;Clinical;clinical translation;cohort;companion animal;companion diagnostics;Companions;Coupling;CT26;Data;Detection;Development;Disease;DNA Damage;Drug Combinations;Drug Delivery Systems;DU145;Effectiveness;efficacy testing;experience;experimental study;Extravasation;FDA approved;feasibility testing;Future;Goals;High Pressure Liquid Chromatography;Human;Image;image-guided drug delivery;imaging agent;Imaging Device;imaging scientist;improved;inclusion criteria;Institutional Review Boards;Investigational Drugs;LAPC4;lymphatic drainage;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Measures;Mediating;men;Metastatic Prostate Cancer;Methods;Modeling;molecular imaging;mutant;Mutation;nanomaterials;nanomedicine;nanoparticle;Neoplasm Metastasis;Normal tissue morphology;novel;novel therapeutics;Outcome;Parents;particle;Patient Care;patient derived xenograft model;Patient Selection;Patients;PC3 cell line;Permeability;Pharmaceutical Preparations;Phenotype;Physicians;Pilot Projects;Play;Poly(ADP-ribose) Polymerase Inhibitor;Polymers;Porosity;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;Prostate Adenocarcinoma;prostate cancer model;Prostate Cancer therapy;Prostatic Neoplasms;Radiation;Radioactivity;Radioisotopes;Radiolabeled;response;Role;Safety;Site;Solid Neoplasm;Testing;testing uptake;Therapeutic;Toxic effect;Tracer;Transgenic Organisms;translational study;Translations;treatment response;tumor;uptake;Vertebral column;Visualization;Zirconium

PROJECT_TITLE: Molecular imaging of novel PARP inhibitor nanomedicine delivery

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Differentiating between causes of shock in the 1.3 million Americans annually who develop shock annually is extremely challenging and requires many clinical experts to provide their perspective. Yet, there is no way for these clinicians to actively share their assessments, build a shared understanding of the cause of shock, and reach a consensus on treatment. The proposed resarch will understand why interprofessional clinicians disagree on the cause of shock, and then design and test a systematic process for interprofessional clinicians to share information, assessments and build a shared understanding of the cause of shock.

PI_NAMEs: BERRY, ANDREW BARNDEN LEWIS;STEY, ANNE M (contact)

PROGRAM_OFFICER_NAME: HAUGSTETTER, MONIKA

PROJECT_TITLE: Shock Patients: Interprofessional Communication to Enhance Diagnosis (SPICED)

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Genetics;Mental Health;Neurosciences;Opioids;Pain Research;Patient Safety;Rehabilitation;Social Determinants of Health

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative Prolonged opioid use after surgery is one of the most common but least understood surgical complications. Little is known about why some people take relatively few opioids, while others go on to consume opioids long after the expected postoperative pain course. This project will examine potential patient factors, including pain sensitivity and transcriptomic influences, on the variation in postoperative pain and opioid use after total knee replacement, a surgery demonstrating great variation in opioid use.

PI_NAMEs: SCHIRLE, LORI  (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Acute;Acute Pain;Adverse effects;Affect;Age;American;Anxiety;Behavioral;Biological;biomarker identification;biopsychosocial;Blood;Brain;Candidate Disease Gene;central sensitization;Chronic;Chronic low back pain;chronic pain;Clinical;Clinical Data;cohort;comorbidity;Complex;conditioned pain modulation;Cross-Sectional Studies;Data;depressive symptoms;design;Development;Disease;DNA;Early identification;Education;Ethnic Origin;Exhibits;Foundations;Future;Gene Expression;Gene Expression Profiling;Genetic;Genetic Variation;genome-wide analysis;Health Care Costs;Helping to End Addiction Long-term;Home;Huntington Disease;Hyperalgesia;Individual;innovation;Inpatients;inter-individual variation;knee replacement arthroplasty;Length;lens;Measurable;Measures;Modeling;Neurodegenerative Disorders;neurophysiology;new therapeutic target;novel;novel strategies;Operative Surgical Procedures;Opioid;opioid epidemic;opioid use;opioid use disorder;Pain;pain catastrophizing;Pain intensity;Pain management;Pain Measurement;pain perception;pain sensitivity;pain symptom;Participant;Patients;Persons;Population;Postoperative Pain;Postoperative Period;potential biomarker;predictive marker;Productivity;prospective;Protocols documentation;psychologic;Psychological Factors;Race;Reporting;Reproducibility;Research;Research Personnel;response;Risk;RNA;Role;Sensory;sex;Sleep;sociodemographic factors;sociodemographics;Solid;Strategic Planning;Substance abuse problem;Surgical complication;surgical pain;Surveys;Symptoms;System;Testing;Time;trait;transcriptomics;United States National Institutes of Health;Variant;Whole Blood;whole genome;Work

PROJECT_TITLE: Variation in Home Opioid Consumption after Total Knee Replacement: Investigating the Role of Pain Sensitivity and Gene Expression

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(83)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Digestive Diseases;Microbiome;Pain Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Irritable bowel syndrome (IBS) affects nearly 11% of the population worldwide, significantly impacts patients’ quality of life and imposes a huge economic burden due to loss of productivity and high healthcare costs. Gut bacteria play an important role in IBS, but the mechanism remains unclear; thus, we do not have effective probiotics to treat IBS. This proposal will uncover how specific bacterial products affect gastrointestinal motility and allow development of more effective probiotic therapies for IBS.

PI_NAMEs: KASHYAP, PURNA C (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Abdomen;Acceleration;Address;adenosine receptor activation;Adrenergic Receptor;Affect;Bacteria;Biological;Butyrates;Categories;Cations;Cell Culture Techniques;Cell Line;Cell Physiology;Colon;Complex;Constipation;Consumption;Data;design;Development;Diarrhea;Disease;Dopamine;Economic Burden;Encapsulated;Enterochromaffin Cells;Epigenetic Process;epigenomics;Feces;Frequencies;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gastrointestinal function;Gastrointestinal Motility;Gastrointestinal Physiology;Gastrointestinal Transit;Gene Expression;Germ-Free;Gnotobiotic;Go Alpha Subunit;Grant;gut bacteria;gut microbes;Health Care Costs;Histone Acetylation;human study;Hypoxanthines;Image;In Vitro;in vivo;Individual;Inflammation;Irritable Bowel Syndrome;Knowledge;Ligands;Link;member;Methods;microbial;microbial based therapy;microbial products;Molecular;mouse model;Mucous body substance;multiple omics;Mus;mutant;Neurons;Norepinephrine;novel;Opitz trigonocephaly syndrome;Organoids;Outcome;Pain;Pathway interactions;Patients;Physiological;Play;Population;Preparation;probiotic therapy;Probiotics;productivity loss;Purinergic P1 Receptors;Quality of life;receptor;receptor expression;Research;response;Rodent Model;Role;Serotonin;Signal Transduction;Site-Directed Mutagenesis;targeted treatment;Testing;Therapeutic;transcriptomics;Transgenic Mice;Tryptamines

PROJECT_TITLE: Mechanisms of alteration of gastrointestinal physiology by gut microbes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(04)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: PORTLAND

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE  The proposed research is to investigate the stage-dependent AMH actions in regulating follicular development and ovarian function, and to evaluate stage-specific AMH modulation in facilitating follicle growth and maturation to improve fertility outcomes. The results will provide critical insight into defining the mechanism of AMH-mediated regulation in cell cycle and energy metabolism during folliculogenesis, developing protocols for optimizing IVF (in vitro fertilization) process, and advancing options for female fertility preservation.

PI_NAMEs: KRIEG, ADAM J (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Adenosine Triphosphate;advanced maternal age;Anabolism;Antral;autocrine;Award;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Proliferation;Consumption;Cortex of ovary;Creatine;Cryopreservation;Data;Development;Embryo;Embryo Transfer;Embryonic Development;Energy Metabolism;Estradiol;Event;Exhibits;experimental study;female fertility;fertility improvement;fertility preservation;Fertilization;Fertilization in Vitro;folliculogenesis;Goals;Gonadotropins;granulosa cell;Growing Follicle;Growth;Human;Hypoxia;Hypoxia Inducible Factor;improved;In Vitro;in vivo;infertility treatment;insight;knock-down;Live-Birth Pregnancy Rate;Macaca;Macaca mulatta;Mediating;Menstrual cycle;Metabolic Pathway;Metabolism;metabolome;Metaphase;Modeling;Molecular;Morphology;mullerian-inhibiting hormone;neutralizing antibody;nonhuman primate;oocyte maturation;Oocytes;Outcome;Ovarian;Ovarian Stimulations;Ovarian Tissue;Ovarian tissue cryopreservation;Ovary;paracrine;Peptides;Physiological;Play;prevent;Primates;Primordial Follicle;Process;Production;Proteins;Protocols documentation;Publishing;Recombinants;Regulation;reproductive function;Reproductive Process;Research;response;Role;success;Supplementation;Testing;tissue culture;transcriptome;Woman

PROJECT_TITLE: Anti-Mullerian Hormone Actions to Control Primate Folliculogenesis

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Prostate Cancer;Urologic Diseases

ORG_CITY: ATLANTA

ORG_DEPT: UROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Prostate cancer is a leading cause of cancer-related death in American men, with lethality due primarily to castration-resistant prostate cancer (CRPC). This study will establish a paradigm-shifting model wherein FOXA1 collaborates with ARID1A, a chromatin modifier, to suppress inflammatory cytokine expression. Further, it will demonstrate the critical role of FOXA1 as a tumor-intrinsic regulator of the PCa immune landscape and pave the way for new therapeutic approaches that sensitize FOXA1-low or mutant CRPC to immunotherapies.

PI_NAMEs: YU, JINDAN  (contact);ZHAO, CHANGSHENG

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: advanced prostate cancer;Affect;American;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;ARID1A gene;Atlas of Cancer Mortality in the United States;Binding;C-terminal;cancer diagnosis;Cancer Etiology;CCL2 gene;CCL20 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell growth;cell motility;Cell Survival;Cells;Cessation of life;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Clinical;Collaborations;CXCL5 gene;cytokine;Cytokine Signaling;Dependence;Development;Enhancers;Epigenetic Process;epigenomics;epithelial to mesenchymal transition;Epithelium;Gene Expression;gene repression;Genes;Human;IL8 gene;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunotherapy;Impairment;Induced Mutation;Infiltration;Inflammatory;inhibitor;insight;Intrinsic factor;knock-down;Knock-out;life span;Macrophage;male;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;men;Mesenchymal;Metastasis Induction;Metastatic Prostate Cancer;Modeling;mouse model;Mus;mutant;Mutate;Mutation;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;novel therapeutic intervention;Operative Surgical Procedures;Pathway interactions;Patients;Phenotype;Play;Point Mutation;Proliferating;Prostate;prostate cancer cell;prostate cancer metastasis;prostate cancer progression;Proteins;Radiation;receptor;recruit;Regulation;Regulatory T-Lymphocyte;Reporting;Repression;Resistance;Resistance development;response;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Somatic Mutation;Testing;TGFB3 gene;Therapeutic;Tissues;Transcription Coactivator;transcription factor;Transcription Repressor;transcriptome;Transgenic Mice;tumor;Tumor Immunity;Tumor-associated macrophages;tumor-immune system interactions;Tumor-infiltrating immune cells;tumorigenesis

PROJECT_TITLE: FOXA1 regulates cytokine signaling and immune landscape in prostate cancer through ARID1A

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-W(80)S]


NIH_SPENDING_CATS: Infectious Diseases;Lung;Pediatric

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: Project Narrative Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection in children and is a cause of respiratory disease in the elderly and the immunocompromised. It therefore has a substantial impact on the healthcare of the US. The goal of these studies is to understand the factors that contribute to inflammation induced by the virus that contributes to the severity of disease.

PI_NAMEs: VARGA, STEVEN M (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Address;Animal Model;Cell Reprogramming;Cells;Child;Chimeric Proteins;Clinical;cytokine;Data;design;Disease;Elderly;Engineering;Ethics;Future;Genes;Glycolysis;Goals;Healthcare;Human;Immune;Immune response;Immune System Diseases;Immunocompromised Host;Impact evaluation;In Vitro;in vivo;Individual;Infant;Infection;Infiltration;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Innate Immune System;insight;interest;Interleukin-1 beta;Interleukin-6;Knockout Mice;Knowledge;Licensing;Link;Lower Respiratory Tract Infection;Lung;Macrophage;Mediating;Metabolic;Metabolism;mouse model;Multiprotein Complexes;Mus;Names;neutrophil;new therapeutic target;Process;Production;Proteins;Reagent;Recombinants;recruit;Reporting;Respiration;respiratory;Respiratory Disease;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Syncytial Virus Vaccines;Respiratory System;response;Role;Severity of illness;Shapes;Signal Transduction;Testing;therapeutic target;vaccine candidate;Variant;Virus

PROJECT_TITLE: Deciphering the complexities of inflammasome activation following RSV infection


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Malaria;Nutrition;Rare Diseases;Vector-Borne Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE There is currently a lack of mechanistic understanding of why humoral immunity against malaria is not efficiently induced. This project will define mechanisms that trigger immune dysregulation during malaria and study the long-term consequences of these events. Determining the pathways that regulate the development and humoral immunity will be broadly important to the fields of infectious disease immunology and vaccinology.

PI_NAMEs: BUTLER, NOAH SULLIVAN (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acceleration;Address;Affect;Affinity;Amino Acid Transporter;Amino Acids;Anti-malarials;Antigens;B-Cell Activation;B-Lymphocytes;Biochemical;Blood;Cell Physiology;Cells;Cellular Metabolic Process;Cessation of life;Communicable Diseases;COVID-19;Data;Dengue;Detection;Development;Diet;Disease;Ebola;Environment;Epigenetic Process;Event;Failure;Genetic;Genetic Transcription;Glutamine;Goals;Human;Humoral Immunities;Hyperactivity;Hypoxia;Immune;Immune response;Immunity;Immunologic Memory;Immunology;Impairment;imprint;improved;Individual;Infection;Infectious Disease Immunology;innovation;Interferons;Intervention;Knowledge;Link;Longevity;Longitudinal Studies;Malaria;Mediating;Memory B-Lymphocyte;Metabolic;Metabolism;Molecular;Mus;Nature;novel;novel strategies;Nutrient;nutrient deprivation;Parasites;pathogen;Pathway interactions;Patients;Pattern recognition receptor;plasma cell development;Plasma Cells;Plasmablast;Plasmodium;Population;Predisposition;programs;Protozoan Infections;Reagent;Receptor Signaling;Reporting;Resistance;Resolution;response;Shapes;Signal Transduction;single cell technology;Spleen;Structure of germinal center of lymph node;Supplementation;System;Testing;tool;Trypanosomiasis;vaccinology

PROJECT_TITLE: Mechanisms and consequences of extrafollicular B cell activation during malaria


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it seeks to determine how gene expression is dynamically regulated by transcription factors and chromatin to direct critical cellular pathways involved in DNA repair, DNA replication and Cell division. This knowledge is important because it will serve as the foundation for development of therapeutics to help modulate cellular growth pathways in diseases such as cancer. Therefore this project is relevant to the part of NIH’s mission of developing fundamental knowledge related to treatment of human disease.

PI_NAMEs: COLEMAN, ROBERT  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Architecture;Binding;Biology;CDKN1A gene;Cell division;cell growth;Cells;Chromatin;cohort;Complex;Data;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Polymerase II;DNA Repair;Exhibits;Foundations;Future;Gene Activation;Gene Expression;Genes;Genetic Transcription;Goals;Grant;histone methylation;Hour;human disease;Image;imaging approach;imaging system;insight;Kinetics;Knowledge;Lead;Length;Link;live cell imaging;live cell microscopy;Malignant Neoplasms;Measures;Memory;Microscopy;Mission;Modeling;Molecular;molecular imaging;Noise;novel;Output;Pathway interactions;Pattern;Peptide Initiation Factors;Phase;Prevalence;Process;promoter;Prothrombin;Public Health;recruit;Regulation;Research;response;SAGA;single molecule;Site;Stimulus;Stochastic Processes;Surveys;System;TAF1 gene;Testing;therapeutic development;Time;TP53 gene;transcription factor;Transcriptional Activation;Transcriptional Regulation;United States National Institutes of Health

PROJECT_TITLE: Dissecting the Dynamic Interplay Between, p53, Chromatin and Transcriptional Bursting in Single Cells

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Hematology

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE This proposal is to identify and test pragmatic strategies to improve timely retrieval of inferior vena cava filters - - devices very commonly implanted but rarely retrieved, resulting in avoidable complications for patients with blood clots -- simultaneously ensuring maturation of this clinician-scientist into an independent investigator.

PI_NAMEs: TRIVEDI, PREMAL S (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Adult;Anticoagulants;Blood coagulation;Blood Vessels;Cardiovascular system;Caring;Child;Clinic;Clinical;Coagulation Process;Colorado;Communities;Computerized Medical Record;contextual factors;Data;Dedications;deep vein;Deep Vein Thrombosis;design;Devices;Doctor of Philosophy;Education;Educational workshop;effectiveness/implementation trial;electronic medical record tool;Ensure;Environment;Excision;experience;follow-up;Fracture;Goals;Guidelines;Health;Health Services;Health system;Heart;Hospitals;Implant;implantation;implementation framework;implementation science;improved;improved outcome;Inferior vena cava structure;Informatics;Injury;Institution;Intervention;Interview;invention;Lead;Leadership;Leg;Life;Literature;Lung;Measures;Medicare;Mentors;Mentorship;Methodology;migration;Morbidity - disease rate;multidisciplinary;Nurses;Organ;Outcome;Outcomes Research;Patient Care;Patient-Focused Outcomes;Patients;Patterns of Care;Penetration;Physicians;pilot test;Positioning Attribute;Practical Robust Implementation and Sustainability Model;pragmatic intervention;prevent;Process;programs;Provider;Publishing;Pulmonary Embolism;Quality of Care;radiologist;Recommendation;Reporting;Research;Research Methodology;Research Personnel;Research Proposals;Resources;Retrieval;Safety;Science;Scientist;skills;Societies;Structure;System;Testing;therapy design;Thrombosis;Time;Training;United States;Universities;Variant;Veins;Vena Cava Filters;venous thromboembolism;Work

PROJECT_TITLE: Implanted but not forgotten: identifying and testing pragmatic strategies to improve inferior vena cava filter retrieval

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Peripheral arterial disease (PAD) is a common complication of diabetes, characterized by decreased vascular supply, ischemia and impaired metabolism in the skeletal muscle. Limited treatment options often lead to limb amputation in alarmingly large number of patients. We plan to investigate the function of a gene named ERR as a potential therapeutic target for PAD via it's stimulatory effects on skeletal muscle metabolism and blood supply.

PI_NAMEs: NARKAR, VIHANG A (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Activities of Daily Living;Aerobic;Aerobic Exercise;Amputation;angiogenesis;Angiogenic Factor;Blood Vessels;Brain Hypoxia-Ischemia;Cardiovascular system;Cell Respiration;Cells;Characteristics;Clinical;comorbidity;Complication;Complications of Diabetes Mellitus;Coupled;Development;Diabetes Mellitus;diabetic;Diabetic mouse;ERR1 protein;Estrogen Nuclear Receptor;Exercise;exercise capacity;exercise intolerance;exercise rehabilitation;Exercise Therapy;Exercise Tolerance;exercise training;Fiber;Functional disorder;Gene Expression;Gene Expression Regulation;Genes;Glucose Intolerance;HIF1A gene;Hindlimb;Hyperglycemia;Hypoxia;Hypoxia Inducible Factor;Impairment;Injections;insight;Intervention;Intramuscular;Ischemia;knock-down;Knock-out;Knockout Mice;Laboratories;Lead;limb amputation;Limb structure;Link;Mediating;Mediator;Medical;Metabolic;Metabolism;mimetics;Mitochondria;mitochondrial dysfunction;Molecular;mouse model;Mus;Muscle;Muscle Fibers;Muscle function;Myopathy;Names;novel;novel therapeutic intervention;Nuclear Orphan Receptor;overexpression;Pain in lower limb;paracrine;Pathology;Patients;Perfusion;Peripheral arterial disease;pharmacologic;Pharmacological Treatment;Physical therapy;programs;Recovery;Recovery of Function;Regulation;Regulatory Pathway;Rehabilitation therapy;Repression;Respiration;response;revascularization;Role;Running;Signal Transduction;Skeletal Muscle;skeletal muscle metabolism;Stimulus;Testing;therapeutic candidate;Therapeutic Intervention;therapeutic target;transcriptome sequencing;Transgenic Mice;Vascular blood supply;Vascular Endothelial Growth Factors;Vascular remodeling;Vascularization;vessel regression;Work

PROJECT_TITLE: New therapeutic strategies for Peripheral Arterial Disease

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: Single stranded DNA has been demonstrated to be hypermutable by a variety of environmental and endogenous mutagens. However, the factors that modulate the susceptibility and specificity of mutagens to ssDNA are not well known. This proposal will investigate genetic factors that impact the mutagenesis of ssDNA in yeast and in cancers.

PI_NAMEs: SAINI, NATALIE  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Acetaldehyde;Alkylating Agents;bioinformatics tool;Bypass;Cell Culture Techniques;Cell Cycle;Cells;Complex;Data;DNA Binding;DNA Damage;DNA damage checkpoint;DNA glycosylase;DNA Repair;Genetic;Genomic Instability;Goals;Human;Individual;interdisciplinary approach;Knowledge;Laboratories;large datasets;Malignant Neoplasms;Mutagenesis;Mutagens;Mutation;next generation sequencing;Outcome;Pathway interactions;Pattern;Polymerase;Positioning Attribute;Predisposition;prevent;Preventive measure;programs;Proteins;replication factor A;Reporter;Research;Research Project Grants;Role;Scientific Advances and Accomplishments;Single-Stranded DNA;Specificity;SS DNA BP;Stretching;System;tool;Work;Yeasts

PROJECT_TITLE: Determining the factors that impact single stranded DNA mutagenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Black family caregivers of older adults with Alzheimer’s disease and/ or related dementias (ADRD) have an increased of risk of mortality as compared to White non-Latino caregivers. Minority caregivers may be able to improve their health outcomes by engaging in specifically designed community-based support programs aimed at increasing caregiver ability and confidence in providing care, perceived rewards of caregiving, and use of adaptive coping strategies. This work addresses a clinical void in culturally responsive interventions developed for Black caregivers of persons with ADRD.

PI_NAMEs: ROBINSON-LANE, SHERIA GRICE (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Address;Age;Alzheimer's disease related dementia;Area;Behavior Therapy;Behavioral;Belief;Black race;Cardiovascular Diseases;care recipients;caregiver quality of life;Caregiver support;Caregivers;caregiving;Caring;Chronic;Chronic Disease;chronic pain;Clinical;Clinical Trials;Cognitive;Cognitive Therapy;Communities;community based research;Community Health;community intervention;coping;Coping Skills;cost;culturally appropriate intervention;Custom;Data;Dementia;Dementia caregivers;design;Development;Diabetes Mellitus;disability;Disease;effective intervention;efficacy testing;Electronics;Ethnic Population;Evaluation;experience;Family;Family Caregiver;feasibility testing;Feedback;Focus Groups;Fostering;Geography;Health;improved;Incidence;information gathering;Intervention;intervention effect;Longitudinal Studies;Marketing;Measures;Mentored Research Scientist Development Award;Minority;Modeling;mortality risk;Nurses;older adult;Outcome;Outcome Study;Participant;patient engagement;Patient Recruitments;Patient Self-Report;Persons;physical conditioning;Physical Function;pilot test;Play;Population;premature;Process;programs;psychological distress;psychosocial outcome;Qualitative Methods;racial population;recruit;Research;Research Design;response;Rewards;Risk;Role;Sampling;satisfaction;Scientist;Self Care;Self Efficacy;Self Management;Shapes;Social support;Spiritual well-being;Spirituality;Stress;stress management;Structure;success;Surveys;Telephone;Testing;therapy design;Time;Training;trend;United States National Institutes of Health;Work

PROJECT_TITLE: Culturally Responsive Support Programming for Black Caregivers of Persons with Dementia

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Mental Health;Palliative Care;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Congruent with the National Cancer Institute’s support of patients and families across the cancer trajectory, researchers will test a problem-solving therapy intervention for family caregivers of individuals with cancer who are receiving outpatient palliative care, providing a much-needed evidence base for caregiver support services in this setting. Potential barriers and facilitators to adoption of the intervention in outpatient palliative care clinics will also be examined, resulting in a greater understanding of the context in which the intervention will be delivered if shown to improve caregiver outcomes.

PI_NAMEs: WASHINGTON, KARLA  (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Address;Adoption;Adverse effects;Ambulatory Care Facilities;American;Anxiety;Attention;attentional control;base;biopsychosocial;cancer care;cancer palliative treatment;cancer therapy;care providers;caregiver interventions;Caregiver support;Caregiver well-being;Caregivers;caregiving;Caring;Clinic;Clinical;comparison group;Complex;Control Groups;coping;Coupled;Data;design;Distress;Effectiveness;Emotional;Event;evidence base;Evidence based intervention;experience;Family;Family Caregiver;family caregiving;frontier;Future;Goals;group intervention;Growth;health care service utilization;Healthcare;Hospitals;improved;Individual;Inpatients;Intervention;Interview;Life;Literature;Malignant Neoplasms;Measures;meetings;Mental Depression;National Cancer Institute;Oncology;Outcome;Outcome Measure;Outpatients;palliative;Palliative Care;Patients;Philosophy;Pilot Projects;Positioning Attribute;preference;problem solving therapy;psychological distress;psychosocial;Qualitative Methods;Quality of life;Randomized;randomized trial;randomized, clinical trials;recruit;Reporting;Research;Research Personnel;response;Risk;Rural;Science;service gap;Service provision;Services;Site;Social Environment;stressor;symptomatology;Testing;Therapeutic Intervention;treatment as usual;United States;Vulnerable Populations;Work

PROJECT_TITLE: Problem-Solving Therapy for Cancer Caregivers: A Randomized Clinical Trial in Outpatient Palliative Care

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative The goal of this project is to design and implement a set of high-throughput reporter assays and computational methods for prioritizing causal genetic variants and identifying driver genes that contribute to the risk for substance use disorders. This is directly relevant to the missions of NIH to improve the capability of diagnosis, treatment, and prevention of these devastating disorders. Similar strategies can be used to study the etiology of other complex diseases.

PI_NAMEs: EDENBERG, HOWARD J (contact);LIU, YUNLONG

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: 3' Untranslated Regions;Adopted;Affect;Alleles;Animals;Astrocytes;Biological Assay;Brain;brain cell;Catalogs;causal variant;Cell Line;cell type;Cells;Code;Complex;Computer Models;Computing Methodologies;Data;design;Diagnosis;Disease;Enhancers;Etiology;experimental study;follow-up;functional genomics;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic variant;Genetic Variation;genome wide association study;genomic variation;Goals;improved;Lead;Machine Learning;Maps;Measures;Mendelian randomization;Methods;Microglia;Mission;Modeling;Multiomic Data;Neurons;Nucleic Acid Regulatory Sequences;Oligodendroglia;Output;Pathway interactions;Phenotype;predictive modeling;Prevention;promoter;Regulatory Element;Reporter;Resources;Risk;Role;Series;Substance Use Disorder;Testing;trait;United States National Institutes of Health;Untranslated RNA;Variant

PROJECT_TITLE: Functional genetic variants in substance use disorders

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ORG_CITY: LEXINGTON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Humans with Type 1 diabetes (T1D) are susceptible to diabetic bone disease and are more likely to suffer a fragility fracture than humans without T1D. Despite this now well-recognized increased risk of osteoporosis and fracture in persons with T1D, it is still not well understood how insulin, or its homolog, insulin-like growth factor 1 (IGF-1), directly affects skeletal well-being in this condition. The studies described in this project will define the relative contributions of insulin and IGF-1 to the molecular, cellular and tissue-level events involved in the development of diabetic bone disease, as well as explore the therapeutic potential of insulin and IGF-1 in preventing and treating diabetic bone disease.

PI_NAMEs: FOWLKES, JOHN L (contact);NYMAN, JEFFRY STEPHEN

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Ablation;Affect;Architecture;bone;Bone Density;bone health;Bone Matrix;bone strength;Characteristics;Clinical;Critical Pathways;Development;Diabetes Mellitus;diabetic;diabetic bone disease;Effectiveness;Event;Evolution;experience;Exposure to;FOXO1A gene;Fracture;fragility fracture;Gene Modified;Glucose;Health;Homologous Gene;Hormones;Human;Hyperglycemia;Impairment;improved;inhibitor;Insulin;Insulin deficiency;Insulin Signaling Pathway;Insulin-Dependent Diabetes Mellitus;Insulin-Like Growth Factor I;Insulin-Like-Growth Factor I Receptor;Intervention;Knockout Mice;Laboratories;Ligands;Maps;mechanical properties;Molecular;mouse model;Mus;Observational Study;Osteoblasts;Osteogenesis;Osteoporosis;osteoprogenitor cell;Pathway interactions;Personal Satisfaction;Persons;pharmacologic;PI3 gene;preclinical study;Predisposition;prevent;Prevention;Production;Proto-Oncogene Proteins c-akt;receptor;Resistance;response;Risk;Rodent Model;Serum;Signal Pathway;Signal Transduction;skeletal;skeletal disorder;Therapeutic;therapeutic target;Tissues;transcriptomics

PROJECT_TITLE: Origins of Skeletal Fragility in Type 1 Diabetes

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Clinical Research;Health Services;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE In regions where malaria transmission is high, chronic asymptomatic malaria infections are common and are major contributors to continued transmission of malaria. A recent field trial showed that asymptomatic screening, testing, and treatment (STT) interventions could reduce transmission from humans to mosquitoes. In this study, I will use agent-based modeling to evaluate the potential impact and cost- effectiveness of STT on long-term malaria control and elimination across a diverse set of epidemiological settings.

PI_NAMEs: HOLDEN, TOBIAS  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: acquired immunity;Affect;Africa South of the Sahara;African;Age;age group;age related;age stratification;Area;arm;asexual;Award;Back;burden of illness;Burkina Faso;Calibration;Case Management;Cessation of life;Chemoprevention;Chronic;chronic infection;Clinical;Clinical stratification;Clinical Trials;combat;Communication;compare effectiveness;cost;cost effectiveness;cost estimate;Country;Culicidae;Data;density;Detection;Dryness;Effectiveness;Epidemiologist;Epidemiology;Familiarity;Fellowship;Fever;field study;global health;Goals;Heterogeneity;Household;Human;improved;in silico;Incidence;Individual;Infection;Infectious Disease Epidemiology;Intervention;intervention effect;Intervention Trial;Malaria;malaria infection;malaria transmission;Malaria Vaccines;Modality;Modeling;models and simulation;National Research Service Awards;novel;Parasites;Persons;Policy Maker;Population;pre-doctoral;prevent;Probability;Publishing;Recording of previous events;Research;Research Personnel;Resources;Role;screening;Seasons;Sex Differentiation;simulation;Site;skills;standard of care;Strategic Planning;Study models;Symptoms;Testing;Time;tool;transmission process;treatment arm;treatment effect;treatment strategy;vector control;Vector-transmitted infectious disease;Work;Writing

PROJECT_TITLE: Quantifying the potential contribution of asymptomatic screening and treatment to malaria control and elimination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Prostate cancer is more common than many other cancers, but its causes are less well understood, partially because research in large, population-based studies has typically been unable to differentiate the molecular subtypes that make up prostate cancer. This proposal seeks to understand in which men some of the most important molecular subtypes of prostate cancer occur; to assess risk factors for specific molecular subtypes to elucidate which subtypes could be prevented and how; and to create new functionality for a widely-used data sharing and exploration platform to make molecular epidemiology data publicly available.

PI_NAMEs: STOPSACK, KONRAD HERMANN (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: Acceleration;Address;Adolescence;Adult;African American;African ancestry;Age;age related;Aging;Androgens;biobank;Biostatistical Methods;Breast Cancer Risk Factor;cancer diagnosis;cancer epidemiology;Cancer Etiology;cancer genomics;cancer risk;cancer type;Carcinogenesis Mechanism;carcinogenicity;cBioPortal;Cells;cohort;Cohort Studies;Common Neoplasm;Communities;Consensus;Credentialing;Data;data exploration;data sharing;Diagnosis;Dietary Practices;Disease;DNA sequencing;early onset;epidemiologic data;ERBB2 gene;Estrogen Receptors;Etiology;ETV1 gene;ETV4 gene;Event;experimental study;Family;Family history of;follow-up;Follow-Up Studies;Gene Fusion;Generations;genetic variant;Gleason Grade for Prostate Cancer;Health;health data;Health Professional;Height;Heterogeneity;human old age (65+);In Situ;In Vitro;Incidence;Inherited;innovation;Insulin-Like Growth Factor I;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Measures;men;Methods;Microarray Analysis;modifiable risk;Molecular;Molecular Epidemiology;Molecular Epidemiology of Cancer;molecular phenotype;Molecular Profiling;molecular subtypes;mortality;MYC gene;Natural History;novel;Obesity;Outcome;Pathology;Physical activity;Physicians;polygenic risk score;Population;population based;Population Study;Prevalence;prevent;Primary Prevention;Progesterone Receptors;prospective;Prospective, cohort study;prostate cancer risk;Prostatic Neoplasms;PSA screening;PTEN gene;Race;Recording of previous events;Research;Risk;Risk Assessment;Risk Factors;Selection for Treatments;Signal Transduction;Smoking;Solid Neoplasm;Tissue Microarray;TMPRSS2 gene;tumor;tumor diagnosis;tumor DNA;tumor heterogeneity;Tumor Subtype;Tumor Suppressor Proteins;Tumor Tissue;Validation;Work

PROJECT_TITLE: Etiologic Heterogeneity Between Molecular Subtypes of Prostate Cancer

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The overarching goal of this K01 Career Development Award is to foster Dr. Andrea Titus’s transition to independence as a social epidemiologist with expertise in examining environmental drivers of cardiovascular disease disparities. The proposed study will draw on multi-level statistical and machine learning approaches to investigate associations between fine particulate matter (PM2.5) and disparities across a range of cardiovascular disease outcomes, leveraging electronic health record data from a national cohort of U.S. veterans. Findings from this work will contribute to the evidence base regarding the pathogenesis of air pollution-attributable cardiovascular outcomes and will shed light on potential population subgroups that may benefit most from targeted interventions to reduce and mitigate air pollution exposures.

PI_NAMEs: TITUS, ANDREA  (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Address;Air Pollutants;Air Pollution;ambient air pollution;Area;Award;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular effects;cardiovascular health;Cardiovascular system;career;Censuses;Cessation of life;Characteristics;Clinical;cohort;Complex;Data;disease disparity;Disease Outcome;Disparity;Disparity population;Economics;Educational workshop;Electronic Health Record;Encapsulated;Environment;Environmental Health;Epidemiologist;Ethnic Origin;evidence base;Exposure to;fine particles;flexibility;Fostering;Goals;Health;health disparity;Hospitalization;Incidence;Individual;Intervention;K-Series Research Career Programs;Link;Literature;long-standing disparities;low socioeconomic status;Machine Learning;machine learning method;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Neighborhoods;novel;Outcome;Particulate Matter;Pathogenesis;Pattern;Policies;Pollution;Population;Predisposition;Procedures;Quasi-experiment;Race;Recording of previous events;Records;Research;Research Design;Residential Mobility;Residual state;Respiratory Disease;Rural;Sampling;secondary analysis;social;social epidemiology;socioeconomic diversity;Socioeconomic Status;Source;statistical and machine learning;stem;Stratification;Structure;Subgroup;symposium;Test Result;Testing;tool;Training;United States;United States Department of Veterans Affairs;urban area;Urbanicity;Variant;Veterans;Wages;Work

PROJECT_TITLE: Identifying disparities in air pollution-attributable cardiovascular health outcomes within a quasi-experimental framework

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

PHR: PROJECT NARRATIVE Klebsiella pneumoniae is a bacterium that frequently causes pneumonia, urinary tract infection, and bloodstream infection and is increasingly causing severe illness and death in hospitalized patients. Resistance to available antibiotics is rising drastically, and new ways to combat this organism are desperately needed. This proposal focuses on understanding the innate and adaptive immune responses to two O-antigen subtypes, O2v1 and O2v2, of Klebsiella pneumoniae to enhance design of vaccines against this pathogen.

PI_NAMEs: ROSEN, DAVID A. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Accounting;Acute;adaptive immune response;Affect;Antibiotic Resistance;Antibiotic-resistant organism;Antibiotics;Antibodies;Antibody Response;Antigens;Bacteria;bacterial fitness;bacterial resistance;bactericide;Bacteriology;Biological Assay;Body Weight decreased;capsule;carbapenem resistant Enterobacterales;carbapenemase;Cessation of life;Clinical;combat;Complement;Conjugate Vaccines;cross immunity;cross reactivity;cytokine;Development;Disease;Enzyme-Linked Immunosorbent Assay;Europe;Exhibits;experimental study;fitness;Flow Cytometry;Future;Galactans;Galactose;Glycosyltransferase Gene;Goals;Gram-Negative Bacteria;healthcare-associated infections;Hospitalization;Hospitals;Human;Humoral Immunities;Immune;Immune response;Immunization;immunogenic;immunogenicity;Immunoglobulin G;Immunologic Techniques;In Vitro;in vivo;Infection;Infection prevention;innate immune function;Innate Immune Response;interest;Klebsiella pneumoniae;Knowledge;Lipopolysaccharides;Literature;Lung;Measures;Mediating;Microbial Biofilms;Monitor;mortality;mouse model;Mus;mutant;Natural Immunity;neutrophil;novel;O Antigens;Organism;Ozone;pathogen;Pathogenesis;Pathogenicity;Patients;Phagocytosis;Phase I Clinical Trials;Phenotype;Pneumonia;pneumonia model;Polysaccharides;Predisposition;prevent;Production;Research Project Grants;Research Project Summaries;Resistance;resistant Klebsiella pneumoniae;Respiratory System;Respiratory Tract Infections;response;Sepsis;Serum;Structure;Surface;Testing;Urinary tract infection;Vaccinated;Vaccination;Vaccine Design;vaccine development;Vaccines;Vertebral column;Virulence;Virulence Factors;Western Blotting

PROJECT_TITLE: Immune recognition of Klebsiella pneumoniae O2v1 and O2v2 O-antigen subtypes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-K(90)]


NIH_SPENDING_CATS: Aging;Genetics;Sarcopenia

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Aging is a complex process where gene expression programs are perturbed. This proposal will uncover a unified model by which RNA methylation regulates coordinated gene programs with aging. Successful completion of the proposed aims should open exciting new prospective and therapeutic possibilities to favor healthy aging and prolong quality of life.

PI_NAMEs: ACCORNERO, FEDERICA  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Address;Adopted;Affect;Aging;aging mechanism;aging process;aging related;Animal Model;Atrophic;Binding;Binding Proteins;Biological;Biological Models;cell age;Cell Physiology;clinically relevant;Complex;Data;Dependovirus;Deterioration;Engineering;Enzymes;Equilibrium;Event;Exercise Tolerance;experimental study;Functional disorder;gain of function;Gene Expression;Gene Expression Process;Genes;Genetic;Genetic Transcription;Growth;Health;healthy aging;Homeostasis;Hypertrophy;in vivo;insight;Knockout Mice;Life;loss of function;Maintenance;Mediating;Mediator;medically necessary care;Messenger RNA;Metabolic;Methylation;Methyltransferase;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;mouse model;Movement;mRNA Translation;Mus;Muscle;muscle aging;muscle form;Muscle function;Muscular Atrophy;novel;novel strategies;old mice;Organ;overexpression;Pathologic;Pathway interactions;Phenotype;Post-Transcriptional Regulation;posttranscriptional;preservation;prevent;Process;programs;prospective;Protein Biosynthesis;protein degradation;Proteome;Quality of life;receptor expression;Regulation;Ribosomes;RNA;RNA methylation;RNA-Binding Proteins;Role;sarcopenia;Signal Transduction;Skeletal Muscle;Stimulus;Testing;Therapeutic;Time;tool;Transcriptional Regulation;Translating;Translations;Tropism;wasting

PROJECT_TITLE: METTL3 in regulation of the aging process

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Clonal hematopoiesis (CH) is associated with increased risk for severe co-morbidities including myeloid malignancy, cardiovascular disease (CVD) and all-cause mortality, which are a significant health concern for which therapeutic approaches have not yet been identified. We hypothesize that targeting the unique inflammatory and metabolic features of HSPC harboring CH-associated mutations can suppress their preferential expansion in the bone marrow (BM), thereby reducing their production of tissue-damaging immune cells that contribute to CVD and other CH-related morbidities. The overall goals of our project are 1) to characterize the role of aberrant glycolytic metabolism as the mechanism selecting for CH HSPC under inflammatory conditions; and 2) establish whether blockade of the NLRP3 inflammasome blocks the inflammatory trigger that drives glycolytic activity and CH HSPC expansion.

PI_NAMEs: PIETRAS, ERIC M (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Address;aging related;Biological Assay;Bone Marrow;Cardiovascular Diseases;Cells;Cellular Metabolic Process;Chronic;chronic inflammatory disease;Clinical;Clonal Expansion;Clone Cells;comorbidity;cytokine;Data;Disease;DNMT3a;Elderly;Evolution;Exhibits;experimental study;Fire - disasters;fitness;Flow Cytometry;Genes;genetic approach;genotoxicity;Glucose;Glycolysis;Goals;Health;Heart;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;HIF1A gene;High Prevalence;Homeostasis;Human;human old age (65+);Hyperactivity;Hypoxia Inducible Factor;Image;Immune;improved;in vivo;Individual;Inflammasome;Inflammation;Inflammatory;inhibitor;innovation;Investigation;Link;Mass Spectrum Analysis;Mediating;Metabolic;metabolic phenotype;Metabolism;Modeling;Molecular Genetics;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutation;Myelogenous;Myeloid Cells;Myeloproliferative disease;novel strategies;Oral Administration;overexpression;Pathogenicity;Pathway interactions;pharmacologic;Phenotype;Prevalence;prevent;Process;Production;Resolution;Risk;Role;Signal Transduction;Smoking History;stem cell expansion;Therapeutic;therapeutic target;Therapeutically Targetable;Tissues;transcription factor;uptake;Work

PROJECT_TITLE: Aberrant glycolysis as a driver of mutant HSPC expansion in clonal hematopoiesis

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Shared decision making prior to lung cancer screening is recommended since lung cancer screening has both benefits and risks. However, shared decision making rarely happens in primary care settings due to difficulty in identifying lung cancer screening eligible patients, lack of patient awareness, lack of provider knowledge, and limited visit time. This pilot study will compare a multi-strategy technology-assisted implementation program to usual care on lung cancer screening uptake, and will provide a foundation for a future large-scale pragmatic trial to improve the uptake of and longitudinal adherence to annual lung cancer screening by supporting shared decision making.

PI_NAMEs: ITO FUKUNAGA, MAYUKO  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Adherence;Agreement;Anxiety;arm;automated text message;Award;Awareness;Benefits and Risks;Cancer Control;Cancer Etiology;cancer prevention;Cardiopulmonary;Cessation of life;Characteristics;Clinic Visits;Clinical;Clinical Informatics;clinical investigation;cognitive interview;Comparison arm;Consumption;Critical Care;Data;Data Collection;design;Development;Education;Electronic Health Record;Electronics;Eligibility Determination;Enrollment;Ensure;Equity;Evaluation;Evidence based practice;experience;Feedback;follow-up;Fostering;Foundations;Funding;Future;Goals;Grant;health communication;health literacy;Health Professional;high risk population;implementation barriers;implementation science;implementation strategy;implementation study;improved;Individual;informant;innovation;Internet;Interview;Knowledge;Language;low socioeconomic status;Lung;lung cancer prevention;lung cancer screening;Malignant neoplasm of lung;Massachusetts;Measures;medical schools;Medicare;Mentored Clinical Scientist Development Program;Mentors;Mentorship;mHealth;Mission;mortality;Motivation;Older Population;Patient Care;Patients;Physicians;Pilot Projects;pilot test;Population;Practical Robust Implementation and Sustainability Model;pragmatic trial;preference;primary care clinic;primary care provider;primary care setting;primary care visit;programs;Provider;Public Health Informatics;Quasi-experiment;Radiation exposure;Randomized;Recommendation;Research;Research Design;Rural Community;Sampling;Scientist;shared decision making;skills;Smoking History;Statistical Data Interpretation;Structure;Surveys;System;Technology;Testing;Text Messaging;Time;tool;Training;treatment as usual;United States;United States National Institutes of Health;United States Preventative Services Task Force;uptake;usability;user centered design;Visit;Work

PROJECT_TITLE: Facilitation of Information Exchange for Shared Decision Making for Lung Cancer Screening

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Eating Disorders;Mental Health;Mental Illness;Nutrition;Obesity;Prevention

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Disordered eating behaviors (DEBs) in type 2 diabetes (T2DM) is an under-recognized clinical issue that has shown to worsen diabetes self-management and increase the risk for health concerns, such as higher triglycerides and poor short-term metabolic control. By partnering with behavioral health providers in real clinical settings and utilizing implementation science methods to evaluate the implementation of a novel intervention to treat DEBs in T2DM, this project has the potential to fill a tremendous unmet need for people with T2DM and accelerate the translation of evidence-based interventions in chronic disease management.

PI_NAMEs: PHIMPHASONE-BRADY, PHOUTDAVONE  (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Acceleration;Address;Adherence;Adoption;Adult;Affect;analytical method;arm;Attitude;Behavior;Behavioral;behavioral health;behavioral health intervention;Behavioral Research;biobehavior;Biological;Blood Glucose;Body mass index;career;Caring;Chronic Disease;Clinic;Clinical;Clinical Trials Design;Cognitive Therapy;Colorado;comparative;Data;Data Analyses;Data Collection;design;diabetes distress;Diabetes Mellitus;diabetes self-management;diet and exercise;Disease;Disease Management;Dissemination and Implementation;Eating;Eating Behavior;Eating Disorders;Education;Educational Intervention;Effectiveness;effectiveness/implementation trial;empowerment;Endocrine;Evaluation;evidence base;Evidence based intervention;Evidence based practice;Evidence based program;Exercise;experience;Fasting;feasibility testing;feasibility trial;fruits and vegetables;Future;glucose monitor;glycemic control;Glycosylated hemoglobin A;Goals;Health;Health Personnel;high body mass index;Hyperphagia;Hypertriglyceridemia;implementation evaluation;implementation framework;implementation science;implementation strategy;improved;Individual;Intake;interest;Intervention;intervention effect;Interview;K-Series Research Career Programs;Laboratories;Learning Skill;Maintenance;Measures;Mediating;Medical;member;Mental Health;Mentors;Mentorship;Metabolic;Metabolic Control;Methods;Neuroendocrinology;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Participant;participant enrollment;Patient Outcomes Assessments;Patients;Persons;Pharmacology;pilot test;Prevention approach;primary care clinic;primary outcome;Procedures;professor;programs;Protocols documentation;Provider;Psyche structure;Psychiatry;Psychologist;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recommendation;recruit;Replicating Effective Programs;Reporting;Research;Research Training;resilience;Risk;Risk Factors;Sample Size;screening;Self Efficacy;self help;Services;skills;Structure;Surveys;Training;Translations;treatment strategy;Universities

PROJECT_TITLE: Balanced and Empowered EaTing (BEET) in Diabetes: A feasibility trial

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Orthopoxviruses;Rare Diseases;Vaccine Related

ORG_CITY: MALVERN

ORG_NAME: VENATORX PHARMACEUTICALS, INC.

ORG_STATE: PA

PHR: PROJECT NARRATIVE In addition to safe and effective vaccines, direct-acting antivirals with complementary mechanisms of action, patterns of resistance and improved toxicity profiles are desperately needed for the Strategic National Stockpile (SNS) to adequately deter the use of smallpox as a bioweapon and to prepare for zoonotic orthopoxviruses with pandemic potential. Following the eradication of smallpox and the subsequent end of the global vaccine campaign, most of the world’s population lost immunological protection to variola virus and to infection by all other orthopoxviruses. As a result, there has been a significant increase in the number of orthopoxvirus spill over events from animal reservoirs into humans. To better prepare for both natural and deliberate threats from orthopoxviruses, we propose high throughput screening of a diversified 200,000 small- molecule library to identify novel antiviral inhibitor classes for the treatment of smallpox disease and other orthopoxviruses with pandemic potential.

PI_NAMEs: COBURN, GLEN  (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Adult;aerosolized;Africa;Animals;Anti-viral Agents;Asia;Biological Assay;Biological Availability;Bioterrorism;bioweapon;candidate selection;Case Fatality Rates;Cells;Cessation of life;Cidofovir;Cowpox virus;cross immunity;cytotoxicity;Development;Disease;Disease Outbreaks;Domestic Animals;Dose;Drug Kinetics;drug-like compound;Environment;Event;Exhibits;Exposure to;Family member;Funding;Future;Genetic;Geographic Distribution;Goals;high throughput screening;Human;human disease;Immunization Programs;Immunologics;improved;Incubated;indexing;Individual;Infant;Infection;inhibitor;Lead;lead optimization;lead series;Libraries;Middle East;Military Personnel;Molecular Target;Monkeypox virus;monolayer;novel;novel virus;Oral;Orthopoxvirus;pandemic potential;pathogen;Pattern;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Population;Predisposition;Preparation;Prevention;Probability;programs;Property;Public Health;Recording of previous events;Reporting;Resistance;response;Risk;Series;Small Business Innovation Research Grant;small molecule;small molecule libraries;Smallpox;smallpox eradication;South America;Structure-Activity Relationship;success;Surface;symposium;Testing;Therapeutic;Toxic effect;transmission process;USSR;Vaccination;Vaccines;Vaccinia;Vaccinia virus;Variant;Variola major virus;Viral;Viral Physiology;Virus;Virus Diseases;Virus Inhibitors;Wild Animals;Zoonoses

PROJECT_TITLE: Discovery of antiviral inhibitors for the treatment of orthopoxvirus infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: Program narrative Africa bears direct morbidity and mortality from poverty-related and neglected tropical diseases including schistosomiasis, which remains endemic in Uganda with an estimated 50% of the population at risk of infection and the associated complications of portal hypertension and fatal upper gastro- intestinal bleeding. Since the description of schistosomiasis in Uganda in the 1950s, efforts to control schistosomiasis remain limited due to incomplete understanding of the pathogen, disease manifestations and transmission mechanisms, and inadequate preventive measures and interventions. Capacity for advanced research training is clearly needed provide schistosomiasis-focused scientists with sufficient capacity to analyze, model and predict relevant clinical case management systems, biological interventions, and disease control efforts in Uganda. 1

PI_NAMEs: ELLIOTT, ALISON ;NAKANJAKO, DAMALIE  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Adult;Advisory Committees;Affect;Africa South of the Sahara;Artificial Intelligence;Behavior;Biology;career;Charge;Collaborations;college;Communities;Computational Biology;Country;Data;Data Science;design;Development;Disease Management;Disease Surveillance;disorder control;Environment;Epidemiology;Exposure to;Faculty;Gastrointestinal Hemorrhage;Genomics;Goals;Grant;Health;Health Sciences;Immunity;Immunology;Infection;Infectious Diseases Research;innovation;Institution;Interdisciplinary Study;International;Intervention;medical schools;Methodology;Modeling;Monitor;multidisciplinary;Needs Assessment;organizational structure;Population;Preparation;Prevention;Process;Production;programs;Research;Research Institute;Research Training;Resources;Risk;Schistosoma;Schistosomiasis;Scientific Advances and Accomplishments;Scientist;Severity of illness;Therapeutic;Training;Training Programs;transmission process;Uganda;Universities;vaccine candidate;vaccinology;vector;vector control;virtual;Virus;Washington

PROJECT_TITLE: Building capacity for Global Infectious Disease Research Training in Schistosomiasis in sub-Saharan Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(55)]


NIH_SPENDING_CATS: Aging;Autism;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Patient Safety

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE High risk for premature mortality is one of the most pressing issues faced by the growing population of autistic older adults but the absence of accurate autism-specific mortality risk prediction tools results in inability to systematically identify those at the highest risk for targeted intervention. This proposal will have a high public health impact by providing critical information about detecting mortality risk among autistic older adults that can ultimately be used to improve life-expectancy among autistic people. This proposal is well-aligned with the NIA’s Strategic Plan, as we seek to “understand disparities related to aging and [inform] strategies to improve the health status of older adults” on the autism spectrum, and NOT-AG-21-020 in that we will analyze existing Medicare claims data to examine “subgroups of older adults with special needs” and “health outcomes in complex multimorbid older adults.”

PI_NAMEs: BISHOP, LAUREN ;HAND, BRITTANY NICOLE (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Academic Medical Centers;adult with autism spectrum disorder;Age;age related;Aging;aging population;Algorithms;Area Under Curve;autism spectrum disorder;autistic;billing data;Characteristics;Chronic;Clinical;clinical practice;Communities;Community Practice;comorbidity;comorbidity Index;Complex;Data;Data Analyses;Disease;Disparity;Elderly;Electronic Health Record;Enrollment;falls;Fatigue;forest;frailty;General Population;Goals;Gold;Health;Health Status;Healthcare Systems;high risk;human old age (65+);improved;indexing;individuals with autism spectrum disorder;innovation;Intervention;Intervention Studies;Life Expectancy;Logic;Machine Learning;Measurement;Measures;Medicare;Medicare claim;member;mortality;mortality risk;novel;Observational Study;older adult;Outcome;outcome prediction;Participant;Pattern;phrases;Population;practical application;predictive tools;preference;Premature Mortality;prospective;Prospective Studies;Public Health;Research;Research Personnel;research study;Risk;Risk Reduction;Sample Size;Special needs;Strategic Planning;Subgroup;Techniques;Testing;Time;Urinary Incontinence;Weight

PROJECT_TITLE: Developing an autism-specific mortality risk index using data from Medicare-enrolled autistic older adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-P(90)S]


NIH_SPENDING_CATS: Biotechnology;Cancer;Networking and Information Technology R&D (NITRD)

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE To realize the full promise of patient-derived xenografts (PDXs) to advance precision therapies for cancer, standardized PDX procedures and coordinated sharing of PDX specimens are needed to validate results across research groups and determine which results may be robust for cancer patients. To address these needs, our PDX Data Commons and Coordination Center unifies the activities of NIH-supported PDX Development and Trial Centers and the National Cancer Institute's Patient-Derived Models Repository. Our Data Commons and Coordination Center uses innovative administrative, cloud computing and bioinformatic approaches to enable PDX method standardization, model sharing, data sharing, and massive-scale data analysis to accelerate translation of PDX studies into cancer clinical trials.

PI_NAMEs: CHUANG, JEFFREY HSU-MIN (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Antineoplastic Agents;Bioinformatics;Biological;Biological Models;Cancer Biology;cancer clinical trial;cancer genomics;Cancer Model;Cancer Patient;Cancer Therapy Evaluation Program;cancer type;candidate identification;candidate marker;Clinical;clinical predictors;Clinical Trials;cloud based;Cloud Computing;Collaborations;Collection;Communication;Communities;computer infrastructure;Coordination and Collaboration;Data;Data Analyses;Data Collection;Data Commons;data modeling;data resource;Data Set;data sharing;data standards;Data Storage and Retrieval;data submission;database of Genotypes and Phenotypes;Databases;Development;diverse data;Drug resistance;efficacy evaluation;Engineering;Environment;experience;Feedback;flexibility;fundamental research;Generations;Genetic;Genomics;genomics cloud;Goals;Grant;Human Resources;Image;improved;Incentives;Information Resources;innovation;insight;Institution;Journals;large datasets;Leadership;Letters;Malignant Neoplasms;Metadata;Methods;Modeling;Molecular;multiple omics;National Cancer Institute;Nature;network models;Outcome;patient derived xenograft model;Patients;Performance;Pharmaceutical Preparations;Phase;pre-clinical;Precision cancer therapy;precision oncology;preclinical study;Process;Publications;Publishing;Recording of previous events;repository;Research;research clinical testing;Resources;response;Review Committee;Science;Scientist;Services;Software Engineering;Specimen;Speed;Standardization;success;The Jackson Laboratory;Therapeutic;tool;Translations;treatment comparison;treatment response;United States National Institutes of Health;Validation;Vision;Work;Xenograft procedure

PROJECT_TITLE: PDXNet Data Commons and Coordinating Center


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Effects of Indoor Air Pollution;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This project will characterize companion (pet) dogs as sentinels for multimorbidities of human cognitive and sensory aging. It will determine the extent to which home environment sources of neurotoxicant heavy metals affect neurocognitive and sensory outcomes in aging and will outline heavy metal-associated metabolic pathways that could be targeted in future therapeutic trials.

PI_NAMEs: MOWAT, FREYA  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Acceleration;Affect;age related;Age-associated memory impairment;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Model;Blindness;Blood;canine model;Canis familiaris;Chemicals;Clinical Trials;Cognition;Cognitive;Cohort Studies;comorbidity;companion animal;Companions;Complex;cost;cost effective;cost efficient;Data;dementia risk;Disease;drinking water;Elderly;Environmental Exposure;Environmental Impact;epidemiology study;experience;exposed human population;Exposure to;Future;Health;Hearing;Heavy Metals;Home;Home environment;House Dust;Human;human model;human morbidity;Impaired cognition;Impairment;innovation;Laboratory Animal Models;life span;Life Style;Link;lipidomics;Longitudinal cohort study;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;metabolomics;Metal exposure;Metals;Methods;middle age;Mission;Modeling;modifiable risk;multiple chronic conditions;Neurocognitive;Neurologic;Neuroprotective Agents;neurotoxic;neurotoxicity;Neurotoxins;offspring;older adult;Organ;Outcome;Outcome Measure;Participant;Pathway interactions;Plasma;Predisposition;Quality of life;Risk;Risk Factors;risk sharing;Sensory;Sentinel;Smell Perception;Source;Specific qualifier value;Testing;Therapeutic;therapeutic target;Therapeutic Trials;Time;timeline;Tissues;Toxic effect;toxicant;Toxicant exposure;translation to humans;United States National Institutes of Health;Vision;Whole Blood;Wisconsin;Work

PROJECT_TITLE: Companion dogs: sentinels for multimorbidity of human neurocognitive-sensory aging and susceptibility to Alzheimer’s disease and related dementias

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative A major goal of HIV-1 vaccine development is induction of effective immune responses. This project will capitalize on our recent structural insights on the membrane-related components of HIV-1 Env to develop innovative immunogen-design strategies to achieve this goal.

PI_NAMEs: CHEN, BING  (contact)

PROGRAM_OFFICER_NAME: CHAKRABARTI, BIMAL KUMAR

PROJECT_TERMS: 2019-nCoV;Animal Model;Antibodies;Antibody Response;Antigens;B-Cell Activation;B-Lymphocytes;Binding;Binding Sites;Cellular biology;Complex;Cytoplasmic Tail;Data;design;Epitopes;Evolution;experience;Glycoproteins;Goals;HIV Envelope Protein gp120;HIV-1;HIV-1 vaccine;Human;human monoclonal antibodies;Immune response;immunogenicity;Immunoglobulin Genes;innovation;insight;Laboratory mice;Length;member;Membrane;Messenger RNA;Modification;Molecular Conformation;Mus;neutralizing antibody;next generation;novel;Peptides;Pharmacologic Substance;Polysaccharides;Production;programs;Property;Protein Engineering;Proteins;rational design;Recombinants;Recording of previous events;Research;Research Personnel;Research Project Grants;response;RNA vaccine;Serum;Structure;Surface;Testing;Transmembrane Domain;Vaccination;vaccine development;Vaccines;vaccinology;Virion;Work

PROJECT_TITLE: Exploring the membrane-related components of HIV-1 Env for immunogen design

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-E(02)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: NARRATIVE The overall goal of this proposal is to dissect the regulation and function, of developmental transcription factors on brain tumor development, and understand how these factors shape the microenvironment. Our studies are important for a more complete understanding of the regulation of gene expression programs in brain cancer.

PI_NAMEs: DENEEN, BENJAMIN ;MACK, STEPHEN C (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Bar Codes;Brain;Brain Neoplasms;Cell Proliferation;Cells;Childhood Malignant Brain Tumor;Chromatin;Chromatin Remodeling Factor;Clinical;Collection;Coupled;Data;Development;Disparate;Electroencephalography;Electroporation;Embryo;Ependymoma;Epigenetic Process;epigenomics;Event;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Fusion;gene repression;Genetic;Genetic Transcription;Genome;gliogenesis;Goals;Growth;Histones;Human;human model;Hyperactivity;in utero;Knowledge;Lead;lead candidate;loss of function;Maintenance;Malignant neoplasm of brain;Malignant Neoplasms;Mediator;member;Metabolic;Modeling;mouse model;Mus;Neuroglia;neuronal tumor;Neurons;neuropeptide Y;Neuropeptides;Neurotransmitters;novel;Oncogenic;overexpression;Pathway interactions;Patients;programs;protein protein interaction;Proteins;Radial;Regulation;RELA gene;Repression;Role;screening;Seizures;Shapes;Site;SMARCA4 gene;Synapses;Testing;Tissue-Specific Gene Expression;transcription factor;Transcriptional Regulation;tumor;tumor initiation;tumor progression;Tumor stage;tumorigenesis

PROJECT_TITLE: Transcriptional Regulation in ZFTA-RELA Ependymoma

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]