FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Primary Health Care;Substance Misuse

ORG_CITY: Boston

ORG_NAME: DYNAMICARE HEALTH, INC.

PHR: PROJECT NARRATIVE Contingency management has successfully increased opioid abstinence and medication adherence in many clinical trials, and buprenorphine is an effective pharmacotherapy in the treatment of opioid use disorder, yet both remain underused as methods to address the opioid epidemic. The purpose of this SBIR fast-track project is to enhance the dissemination of contingency management and increase prescribers’ willingness to serve buprenorphine patients by implementing an incentivized collaborative care model that links their practice to a digital health program that features contingency management at its core. If successful, this project will lead to substantially enhanced access to contingency management services and buprenorphine treatment on a national scale.

PI_NAMEs: DEFULIO, ANTHONY ;GASTFRIEND, DAVID R (contact)

PROGRAM_OFFICER_NAME: FLOOD, MORRIS

PROJECT_TERMS: Abstinence;addiction;Address;Adoption;Agreement;alcohol use disorder;arm;Award;base;Behavioral;Buprenorphine;buprenorphine treatment;Caring;Client satisfaction;Clinic;Clinical;Clinical effectiveness;Clinical Trials;collaborative care;contingency management;Costs and Benefits;Counseling;Data;Data Collection;Data Display;design;Development;digital;digital health;digital treatment;drug abstinence;economic evaluation;economic outcome;efficacy evaluation;Enrollment;Ethical Review;evidence base;Feasibility Studies;Feedback;Fees;Health;health economics;Improve Access;incentive-based intervention;Incentives;information display;Insurance Carriers;Intervention;Legal;Link;Manuals;Marketing;Measures;Medicaid;medication compliance;Meta-Analysis;Methods;Modeling;Monitor;Motivation;Nicotine Use Disorder;novel;Opioid;opioid epidemic;opioid use disorder;Outcome;Outcome Measure;Outpatients;Participant;patient engagement;Patient Monitoring;Patient-Focused Outcomes;Patients;payment;Peer Review;Performance;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Physicians;Policies;primary outcome;Procedures;product development;programs;Provider;provider behavior;psychosocial;Randomized, Controlled Trials;recruit;Research;Sampling;satisfaction;secondary analysis;service delivery;Service delivery model;Services;Small Business Innovation Research Grant;Substance Use Disorder;success;System;Techniques;Technology;Testing;Time;Training;treatment adherence;treatment planning;trend;United States;Urine;willingness

PROJECT_TITLE: Incentivized Collaborative Care to Desseminate Contingency Management


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Gene Therapy;Genetics;Hematology;Immunotherapy;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Development of chimeric antigen receptor (CAR) T cell therapy for acute myeloid leukemia (AML) has been limited in part by a lack of truly tumor-specific target antigens, which can render healthy tissues susceptible to “on-target, off-tumor toxicity.” Engineering combinations of activating and inhibitory synthetic receptors into CAR T cells will address this challenge by enhancing tumor specificity. Here, I will identify inhibitory motifs and critical signaling mechanisms within CAR T cells that will contribute to the design of next-generation CAR T cells for AML, with a specific focus on circumventing endothelial cell toxicity.

PI_NAMEs: RICHARDS, REBECCA MARGARET (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;acute toxicity;Adaptor Signaling Protein;Advisory Committees;Antigen Targeting;Antigens;antileukemic activity;B lymphoid malignancy;Bioinformatics;Biological Models;cancer cell;candidate identification;CAR T cell therapy;career development;CD19 gene;Cell Line;Cell-Mediated Cytolysis;Cells;Cellular biology;chemotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;clinical translation;Cytometry;cytotoxicity;Data;Data Set;design;Development;Development Plans;Diagnosis;education planning;Endothelial Cells;Endothelium;engineered T cells;Engineering;Environment;Equilibrium;Event;experimental study;extracellular;Flow Cytometry;Foundations;Genetic Transcription;Goals;Green Fluorescent Proteins;Growth;Hematopoietic;Hematopoietic stem cells;high dimensionality;Immune system;Immunohistochemistry;Immunology;Immunotherapy;improved;in vitro Model;in vivo;innovation;interest;Interruption;Investigation;leukemia;leukemia initiating cell;leukemic stem cell;Link;Logic;Malignant Neoplasms;Measures;Mediator;Mentors;Mentorship;neoplastic cell;next generation;Non-Malignant;Normal tissue morphology;novel;Patients;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physicians;Predisposition;preservation;Protein Dephosphorylation;protein expression;Protein Tyrosine Phosphatase;Proteomics;PTPN6 gene;receptor;Receptor Activation;Receptor Signaling;recruit;Recurrence;Regulation;Reporter;Research Activity;Research Personnel;Resources;Safety;Sampling;Scientist;Signal Transduction;Signaling Molecule;skills;Stem cell transplant;Structure;success;Surface;Survival Rate;T-Cell Activation;T-Cell Receptor;Techniques;Technology;Testing;therapeutic target;Tissues;Toxic effect;Training;Transcriptional Activation;transcriptome sequencing;transcriptomics;transmission process;tumor;tumor specificity;United States;Universities;Work

PROJECT_TITLE: NOT-gated CAR T cells to overcome on-target, off-tumor toxicity in AML

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Disease;Regenerative Medicine

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: No change   Modified Specific Aims The remarkable regenerative potential of the liver in young mammals is due to the ability of quiescent hepatocytes to nimbly respond to mitogenic signals. This potential is attributed to the coordinated regulation of genes that drive proliferation. We [1, 2] and others [3] demonstrated that this transcriptional response is governed by a hepatic epigenetic code characterized by bivalent marks on pro-regenerative genes and that there is a repressive code on transposable elements (TEs). Our central hypothesis is that the youthful epigenetic code permits transcription factor access to pro-regenerative genes while restricting access to TEs, and that this code is rewritten during aging, resulting in TE activation, parainflammation [4, 5] and regenerative decline [6-8]. To test this, we will establish which elements of the code are critical for regeneration and TE suppression in young animals, determine the mechanism by which these elements compensate for each other in response to epigenome repatterning, and will then define how this code changes during aging.  Using a machine learning approach on multi-omic datasets, we defined the relationship between the chromatin states that comprise the epigenomic landscape in young, quiescent mouse livers and the expression of genes and TEs both in quiescent and regenerating livers following partial hepatectomy (PH) [2]. As expected, TEs are silent, and reside in closed chromatin states, while highly expressed genes fundamental to liver function reside in open states. Surprisingly, open chromatin states also contained thousands of genes that were silent in quiescent livers, including pro-regenerative, E2F target genes. We found that these genes were bivalently marked with active (H3K4me3) and repressive (H3K27me3) modifications in quiescent livers, and, strikingly, that H3K27me3 was depleted from their promoters following PH, concomitant with their activation. This suggests that H3K27me3 is a key element of the epigenetic code that confers regenerative potential to the liver. This is supported by our finding that hepatocyte specific knockout of a key DNA methylation factor, Uhrf1 (Uhrf1HepKO) results in the repatterning of H3K27me3, so that it is depleted from promoters of E2F target genes and enriched on hypomethylated TEs in a process we termed epigenetic compensation. The result is that Uhrf1HepKO mice show premature and sustained activation of pro-regenerative genes and enhanced liver regeneration following PH [1]. We will use a combination of genomic and functional approaches to investigate the role of H3K27me3 in gene and TE regulation in quiescent and regenerating livers and in epigenetic compensation. This will advance the important goal of understanding how the young liver epigenome sustains liver regeneration and suppresses transposon threat, which could be leveraged to develop therapeutic interventions to sustain liver health.  The loss of regeneration capacity in the aged liver [12-17]. is accompanied by widespread epigenetic changes, TE activation and inflammation [9-11]. We hypothesize that these are linked due to shifting of pro-regenerative genes to repressive chromatin states and TEs to active ones. The finding that young animals with constitutive H3K27me3 depletion in hepatocytes develop some of these phenotypes found in older animals [18-20], combined with our hypothesis that H3K27me3 is a key element in the hepatic epigenetic code in young animals, suggests that this mark as a regulator of the hepatic healthspan. We will test the exciting possibility that promoting epigenetic compensation in aged livers could rejuvenate them by facilitating activation of pro-regenerative genes. If successful, this could guide development of therapies to augment regeneration in elderly patients and those suffering from liver failure. specific aims, we will to uncover fundamental mechanisms about how the epigenome regulates genes, TEs and regeneration in the liver throughout the lifespan:  Aim 1. Determine the role of H3K27me3 and Uhrf1 in setting the epigenetic code in young livers. Hypothesis: Epigenetic compensation in Uhrf1HepKO livers shifts H3K27me3 from promoters to suppress TEs. NEW Approaches: In Uhrf1HepKO and WT mouse livers, we will:  1A. Profile genome occupancy of E2F1 and EZH2; and 1B. Deplete H3K27me3 from hepatocytes using pharmacological and genetic approaches and evaluate the effects on TE and gene expression in quiescent and regenerating livers.  Aim 2. Decipher how aging rewrites the hepatic epigenetic code.  Hypothesis: Pro-regenerative genes shift to repressed chromatin states and TEs to active states in aged livers.  NEW Approach: Using publicly available epigenomic data, define chromatin state and transcriptomics of aged human and mouse livers and determine how these changes relate to regeneration component in young livers.  Aim 3. Determine if epigenetic compensation can rejuvenate the liver.  Hypothesis: Epigenetic compensation induced in young mice can extend the youthful epigenetic code to prevent TE expression, parainflammation and enhance liver regeneration during aging.  Approach: Induce epigenetic compensation in young mice by constitutive Uhrf1HepKO and inducible H3K27me3 depletion and, when these animals age, assess changes in TE and gene expression and liver regeneration.

PI_NAMEs: SADLER EDEPLI, KIRSTEN C (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acceleration;access restrictions;Age;aged;Aging;animal old age;Animals;Cell Physiology;Chromatin;Code;Compensation;Complex;Cytoprotection;Data;Data Set;DNA;DNA biosynthesis;DNA Damage;DNA Methylation;DNA Transposable Elements;E2F transcription factors;Elderly;Elements;Epigenetic Process;epigenome;epigenomic profiling;epigenomics;EZH2 gene;flexibility;Foundations;gene discovery;Gene Expression;Gene Expression Regulation;Gene Silencing;Genes;genetic approach;Genetic Transcription;Genome;Genomic Instability;Genomics;Goals;Health;healthspan;Hepatic;Hepatocyte;Human;Inflammation;juvenile animal;Knock-out;life span;Link;Liver;Liver Failure;liver function;Liver Regeneration;Machine Learning;Mammals;Modification;Molecular;Multiomic Data;Mus;Natural regeneration;novel strategies;old mice;older patient;Outcome;Partial Hepatectomy;Pattern;pharmacologic;Phenotype;premature;prevent;Process;programs;Proliferating;promoter;regeneration potential;regenerative;Regenerative capacity;Regulation;Rejuvenation;Repression;response;Role;Signal Transduction;Testing;Therapeutic Intervention;therapy development;transcription factor;transcriptomic profiling;transcriptomics;Work;Writing

PROJECT_TITLE: Regulation of Liver Regeneration by UHRF1

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative:  The proposed research will elucidate the role of acid sensing ion channels (ASICs) and proton in mediating synaptic transmission between Merkel cells and A-afferent fibers, which will uncover the transmission mechanism underlying the sense of touch at Merkel discs. This is highly relevant to public health because it will uncover a new mechanism underlying the sense of touch. This new mechanism will further provide important insights into sensory dysfunctions under pathological conditions such as diabetic and chemotherapy-induced peripheral neuropathy and thereby will have therapeutic implications.

PI_NAMEs: GU, JIANGUO  (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Acids;Action Potentials;Amyloid beta-Protein;ASIC channel;ATP phosphohydrolase;Award;Behavioral;Binding;Cells;chemotherapy;Chemotherapy-induced peripheral neuropathy;Clinical;Data;Dependence;Detection;diabetes mellitus therapy;diabetic;Digit structure;Discrimination;Fiber;Functional disorder;Generations;Hair follicle structure;Human;Immunohistochemistry;Impairment;insight;Ion Channel;ion channel blocker;Ions;Knockout Mice;Knowledge;leukemia;Ligands;Light;Lymphoma;Malignant neoplasm of lung;Malignant Neoplasms;Mammals;Mechanical Stimulation;Mechanics;Mediating;Merkel Cells;Molecular;Molecular Probes;mouse genetics;Mus;Nature;novel;Numbness;Organ;patch clamp;Pathologic;Patients;Peptides;Pharmaceutical Preparations;Pharmacology;Physiology;Piezo 2 ion channel;Play;postsynaptic;pressure;Protein Isoforms;Proton Pump;Protons;Public Health;Quality of life;Rattus;Reporting;Research;response;Rodent;Role;Scientific Advances and Accomplishments;sensor;Sensory;severe injury;Signal Transduction;Social Interaction;Spottings;Stimulus;Structure;Synapses;Synaptic Receptors;Synaptic Transmission;Synaptic Vesicles;Tactile;Techniques;Testing;Therapeutic;Time;Touch sensation;Toxin;transmission process;Vibrissae;Vincristine

PROJECT_TITLE: Cellular and Ion Channel Mechanisms Underlying the Sense of Light Touch in Mammals

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Brain Disorders;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention

ORG_CITY: FORT COLLINS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative  Many studies demonstrate that various environmental toxicants, including heavy metals, pesticides, and infectious pathogens, confer increased risk for Parkinson’s disease (PD) and Alzheimer’s disease (AD). How cumulative environmental exposures to such agents throughout lifespan can promote the development of PD and related disorders remains largely unanswered. The key question being addressed by this R35/RIVER application is how the neuro-immune axis responds to environmental exposures encountered across the lifespan and how the combination of such exposures can trigger the onset of neurological disease.

PI_NAMEs: TJALKENS, RONALD  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Address;Affect;Age;Aging;Alzheimer's Disease;Bacteria;Brain;Cells;Central Nervous System;Complex;Development;Disease;Environmental Exposure;Event;Exposure to;Generations;Genetic;glial activation;Goals;Heavy Metals;Human Resources;Image;Immune signaling;Infectious Agent;Inflammatory;Inflammatory Response;Informatics;Innate Immune Response;life span;Link;Longitudinal Studies;Molecular;Molecular Profiling;Movement Disorders;Nerve Degeneration;Nervous System Disorder;Network-based;neural network;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuroglia;Neuroimmune;neuroinflammation;neurotoxic;Neurotoxins;Parkinson Disease;pathogen;Pathway interactions;Pesticides;Phase;Phenotype;Population;protein aggregation;Regulation;Resources;Risk;Risk Factors;Signal Transduction;tool;Toxic Environmental Substances;Toxicant exposure;transcriptomics;Transgenic Model;Virus;Virus Diseases

PROJECT_TITLE: Deciphering innate immune signaling mechanisms in glial cells linking lifetime environmental exposures to neuroinflammation, protein aggregation and neurodegeneration in Parkinsons disease


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Substantial evidence supports the use of medications to mitigate the harms associated with OUD, but 80% of people with OUD receive no treatment and only a third of those who do access treatment receive evidence- based medications. The present study proposes to develop and test a telehealth intervention for OUD treatment delivery specifically designed for marginalized patients who are likely to struggle with in-person treatment models, which has the potential to impact public health by increasing access to medications for OUD. The mentorship, training, and research activities in this application will prepare the candidate for an independent scientific career conducting intervention research to improve access to substance use disorder treatment and harm reduction services via innovative, low-barrier delivery models.

PI_NAMEs: ARONOWITZ, SHOSHANA V. (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;Applications Grants;Attitude;Black race;Buprenorphine;career;career development;Caring;Case Management;Characteristics;Child Care;Cities;Client satisfaction;Clinic;Clinical effectiveness;Color;Communities;community engaged research;community setting;Country;COVID-19 pandemic;Data;Dedications;design;Development;Development Plans;Drug Screening;Drug usage;Drug user;effective intervention;effectiveness outcome;effectiveness/implementation trial;Enrollment;Equity;Ethics;Ethnography;evidence base;experience;follow-up;Foundations;Frontline worker;geographic barrier;Goals;Grant;Harm Reduction;Health Promotion;Health Services Accessibility;Health Services Research;Hospitals;housing instability;human centered design;implementation barriers;implementation facilitators;implementation outcomes;Improve Access;Individual;innovation;Intervention;intervention mapping;Intervention Studies;Interview;K-Series Research Career Programs;Latino;Lead;Learning;marginalization;marginalized population;Medical;medication for opioid use disorder;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentorship;Modeling;Morbidity - disease rate;mortality;National Institute of Drug Abuse;Neighborhoods;non-opioid analgesic;Opioid;opioid use disorder;Overdose;overdose death;Participant;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;Philadelphia;pilot trial;Policies;Poverty;Prevention;primary outcome;programs;prototype;Provider;Public Health;Reduce health disparities;Research;Research Activity;research and development;Research Personnel;Scientist;secondary outcome;segregation;Self Efficacy;Service delivery model;Services;skills;social stigma;Subgroup;substance use;Substance Use Disorder;System;Technology;telehealth;telehealthcare;Testing;therapy development;Training;Training Activity;Training Programs;Transportation;treatment as usual;treatment program;Underserved Population;United States;Validation;Videoconferencing;Visit;Work;Writing

PROJECT_TITLE: Improving access to opioid use disorder treatment among marginalized patients with a tailored telehealth intervention

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Eukaryotic cells encode thousands of different membrane proteins that are critical for growth and survival. We have discovered a new pathway that directs the biogenesis of multi-pass membrane proteins at the endoplasmic reticulum membrane. Deﬁning how the cellular machinery coordinates this fundamental process is essential for understanding how healthy cells function, with important implications for the treatment of human diseases.

PI_NAMEs: KEENAN, ROBERT J (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Anabolism;Biochemical;Biogenesis;Bioinformatics;Biological;Cell membrane;Cell Physiology;Cells;Cellular biology;Code;Endoplasmic Reticulum;Enzymes;Eukaryota;Eukaryotic Cell;Genes;Genetic;Growth;Human;human disease;Human Genome;insight;Link;Membrane;Membrane Proteins;Molecular;novel;Pathway interactions;Process;Prokaryotic Cells;Proteins;receptor;Transmembrane Domain;Work

PROJECT_TITLE: Membrane protein biogenesis at the ER

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Immunization;Infectious Diseases;Pediatric;Prevention;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Oral vaccines, such as those to protect against rotavirus infection, are less effective in infants in low- and middle- income countries. Infections with enteroviruses at the time of initial vaccination have been implicated as interfering with immune responses to these vaccines, but the mechanisms underlying this interference remain unclear. Understanding how enterovirus infections limit oral vaccine responses, and evaluating whether they may interfere with non-oral vaccines, will be critical to optimizing vaccine administrations to best protect children worldwide from serious viral illness.

PI_NAMEs: BALDRIDGE, MEGAN T (contact);HARRIS, VANESSA CATHERINE;RAMANI, SASIREKHA

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: adaptive immune response;adaptive immunity;Adult;Cessation of life;Child;Childhood;Clinical;clinical efficacy;Clinical Trials;co-infection;cohort;compare effectiveness;Country;Coxsackie Viruses;cytokine;Data;Development;Diarrhea;Enteral;Enterovirus;Enterovirus Infections;Environment;Epithelial Cells;Epithelium;Evidence based intervention;Family Picornaviridae;gastrointestinal epithelium;Ghana;Goals;Hospitalization;Human;Immune;Immune response;Immunity;immunogenicity;immunoregulation;improved;in vivo;Income;Infant;Infection;innate immune pathways;Innate Immune Response;insight;Integration Host Factors;Interferons;Intestines;knockout gene;Knockout Mice;Life;low and middle-income countries;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Oral;Oral Poliovirus Vaccine;oral vaccine;Organoids;Outcome;Pathway interactions;Performance;prevent;Research Personnel;Risk;RNA Viruses;Role;Rotavirus;Rotavirus disease;Rotavirus Infections;Rotavirus Vaccines;seroconversion;Signal Pathway;Signal Transduction;Signaling Molecule;stool sample;System;Testing;Time;TNF gene;Transgenic Organisms;Vaccination;vaccine effectiveness;vaccine efficacy;vaccine immunogenicity;vaccine response;vaccine trial;Vaccines;vaccinology;Variant;Viral;Viral Interference;virome;virus virus interaction;Work;Zambia

PROJECT_TITLE: Enterovirus interference with rotavirus vaccine replication and immunity

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The BabySeq Project was the first randomized controlled trial of genomic sequencing (GS) in apparently healthy infants and provided striking data supporting the medical utility and cost effectiveness of GS in an early adopter cohort. In order to disseminate this technology equitably, it will be crucial to understand its impact on ethnically, racially and socio-economically diverse populations and their health care providers. The goals of this proposed study are to use the infrastructure and protocols developed in BabySeq to study medical, behavioral and economic outcomes associated with implementing GS in an under-represented population of infants at three diverse CTSA sites across the U.S.

PI_NAMEs: GREEN, ROBERT C. (contact);HOLM, INGRID ADELE

PROGRAM_OFFICER_NAME: GOPAL-SRIVASTAVA, RASHMI

PROJECT_TERMS: Address;African American;African ancestry;Age Months;Age of Onset;arm;Behavioral;behavioral outcome;Boston;Childhood;Clinical;clinical care;Clinical Trials;cohort;Communication;Communities;community engagement;Copy Number Polymorphism;cost;cost effectiveness;Data;design;Diagnostic;Disclosure;Disease;disorder risk;Distress;distrust;economic impact;economic outcome;Education;Educational Curriculum;Enrollment;Equity;ethnic diversity;Ethnic Origin;exome sequencing;experience;Family;Family history of;Family member;Feedback;Focus Groups;follow-up;Funding;Future;Genes;genetic counselor;Genetic Predisposition to Disease;genome resource;genome sequencing;Genomics;Geographic Locations;Goals;Health Benefit;Health Care Costs;health care service;health care service utilization;Health Expenditures;Health Personnel;Healthcare;Hispanic;Hispanic ancestry;Iatrogenesis;improved;Infant;Information Management;Infrastructure;innovation;Inpatients;interest;Interview;Laboratories;Learning;Life;Light;Longitudinal Surveys;Medical;Medical Records;Mendelian disorder;Methods;Minority Groups;Modeling;Monitor;Morbidity - disease rate;multidisciplinary;New York City;Newborn Infant;Newly Diagnosed;novel;novel strategies;Outcome;Outpatients;Parent-Child Relations;Parents;Participant;participant enrollment;Pathogenicity;Patient Self-Report;pediatrician;Penetrance;Phenotype;Population;Population Heterogeneity;prevent;primary care setting;programs;Protocols documentation;Psychological Impact;psychosocial;Psychosocial Assessment and Care;Race;racial diversity;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Reporting;Research;Resources;response;retention rate;screening;Site;socioeconomics;Structure;Surveys;Symptoms;Technology;Testing;Training;two-arm study;Underrepresented Minority;Underrepresented Populations;underserved community;Underserved Population;United States National Institutes of Health;Variant;Vision;whole genome

PROJECT_TITLE: Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants


ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Public health relevance Our studies will generate new mechanistic concepts and principles in understanding how cytosolic double- stranded DNA sensing pathways are activated and regulated at the molecular level. New insights and robust assays arising from our research will also aid in the development of therapies targeting various human inflammatory diseases involving these sensors.

PI_NAMEs: SOHN, JUNGSAN  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Active Sites;Autoantigens;Biochemical;Biological Assay;Cells;cofactor;Coupled;Cytosol;Dimerization;Disease;ds-DNA;Electron Microscopy;Foundations;Host Defense;Human;human disease;Inflammatory;Innate Immune System;insight;Invaded;Link;Measurement;mechanical force;Metals;Methods;Molecular;novel therapeutic intervention;Nucleotides;pathogen;Pathway interactions;Periodicity;Phase;programs;public health relevance;Radiation induced damage;Regulation;Research;Role;sensor;Signal Pathway;Signal Transduction;single molecule;Stigmatization;targeted treatment;Testing;therapy development;X-Ray Crystallography

PROJECT_TITLE: Mechanistic Studies of cytosolic double-stranded DNA sensing pathways.


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Primary Health Care;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This project will examine the impacts of insurance expansion policies and federal workforce incentives on timely access to needed surgical care. Though such policies are generally studied in isolation, our approach takes advantage of a double natural experiment to evaluate isolated and combined effects that have not yet been described. Our findings will inform ongoing political debates over the merits and mechanisms of policies aimed at improving access to care through insurance coverage and workforce incentives.

PI_NAMEs: IBRAHIM, ANDREW MOUNIR (contact);SCOTT, JONATHAN WILLIAM

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Abdominal Aortic Aneurysm;Adopted;Adverse event;Advocate;Age Distribution;American;Area;beneficiary;Caring;Colonic Diseases;Colorectal Cancer;Communities;Complication;Congresses;cost;Country;County;Crowding;Data;demographics;density;Disease Progression;Eligibility Determination;Emergency Situation;Evaluation;evidence base;experience;Exposure to;Geography;Health Care Costs;Health Insurance;Health Occupations;health professional shortage areas;Health Services Accessibility;Health system;Healthcare;Hernia of abdominal cavity;high risk;hospital readmission;Improve Access;improved;incentive program;Incentives;Income Distributions;Individual;Inpatients;Insurance;Insurance Coverage;Intervention;Life;Measures;Medicaid;Medicare;Medicare claim;Methods;Modification;mortality;Natural experiment;Obstruction;operation;Operative Surgical Procedures;Outcome;Outpatients;Patients;Policies;Policy Maker;Policy Making;Politics;prevent;Primary Care;primary care provider;Procedures;Provider;Quasi-experiment;Research Design;Resources;response;Rupture;Schedule;simulation;Surgeon;Symptoms;Techniques;Testing;Tracer;Uninsured;United States;United States Centers for Medicare and Medicaid Services;Variant;Ventral Hernia

PROJECT_TITLE: Insurance Coverage and Workforce Incentives to Improve Access to Surgical Care

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Harm Reduction for Substance Misuse;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Dual use of e-cigarettes and cigarettes is common among adults in the United States. Most dual users report using e-cigarettes with the intention of quitting; however, these cigarette smokers are faced with contextual barriers/facilitators to harm reduction as well as daily triggers and settings associated with cigarette smoking. This study proposes identifying these barriers/facilitators and daily triggers and settings of cigarette smoking in adult dual users, which will provide evidence to help research and clinical practice for effective intervention methods to address barriers to harm reduction.

PI_NAMEs: OSIBOGUN, OLATOKUNBO  (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: 21 year old;Address;Adult;Age;Applications Grants;Behavior Therapy;career development;Cigarette;Cigarette Smoker;cigarette smoking;cigarette user;clinical practice;cohort;Competence;contextual factors;Data;design;Development;Development Plans;Ecological momentary assessment;effective intervention;Effectiveness;Electronic cigarette;electronic cigarette use;electronic cigarette user;epidemiology study;experience;Face;Focus Groups;Goals;Harm Reduction;improved;Individual;insight;Intention;interest;Intervention;K-Series Research Career Programs;Knowledge;Learning;Life;longitudinal analysis;Mentors;Methodology;Methods;Nicotine;Nicotine Dependence;nicotine replacement;Outcome;Participant;Pattern;Phase;Pilot Projects;Population;Population Assessment of Tobacco and Health;Positioning Attribute;prevent;Public Health;Qualitative Methods;Randomized, Controlled Trials;recruit;Reporting;Research;Research Design;Research Personnel;Risk;skills;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;social cognitive theory;Statistical Methods;Study Subject;Symptoms;Techniques;therapy design;therapy development;Tobacco;tobacco products;Tobacco use;tool;Training;Translating;United States;Woman

PROJECT_TITLE: Identifying barriers and facilitators of harm reduction among adult dual users of e-cigarettes and cigarettes

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Eye Disease and Disorders of Vision;Health Services;Neurosciences;Pediatric;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Amblyopia is the leading cause of vision loss in children worldwide and the majority of blind children live in low- and middle-income countries. The current standard of care for amblyopia screening is to use devices which detect amblyopia risk factors (ARF) with high false positive rates causing over-referral, unnecessary examinations for children, and increased healthcare cost and resource utilization. This clinic- and community- based study in Nepal will be the first to compare the efficacy and cost of two amblyopia screening strategies and devices: one which detects amblyopia directly using a novel retinal birefringence scanner (RBS) device and the other which detects ARF using an autorefractor (AR) screening device.

PI_NAMEs: OATTS, JULIUS  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Adult;aged;Amblyopia;Biometry;Birefringence;blind;Blinded;Blindness;Boston;California;Child;Childhood;Clinic;Clinical Trials Design;Cluster randomized trial;Collaborations;Communities;Community Outreach;comparative cost effectiveness;comparative efficacy;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;Country;Data;Detection;detection sensitivity;Development;Devices;Diagnosis;diagnostic accuracy;diagnostic screening;diagnostic technologies;Early Diagnosis;economic evaluation;Education and Outreach;Educational Intervention;efficacy evaluation;Enrollment;Environment;Epidemiology;Eye;FDA approved;Foundations;Funding;Future;Glaucoma;Goals;handheld equipment;Health Care Costs;Human Resources;Income;Infrastructure;innovation;International;Intervention;invention;low and middle-income countries;low income country;Mentors;Mentorship;Methodology;Monitor;Monocular Vision;Nepal;new technology;novel;novel diagnostics;Ophthalmologist;Ophthalmology;Outcome;Pediatric Hospitals;Performance;peri-urban;Population;Prevalence;prevent;Prevention;programs;Randomized;randomized trial;Refractive Errors;Research;Research Design;Research Personnel;Resource-limited setting;Resources;Retina;Risk;Risk Factors;San Francisco;Schools;screening;screening program;Services;Specificity;standard of care;success;Techniques;Technology;Testing;Training;United States National Institutes of Health;Universities;Urban Community;Vision;Vision Screening;Visual impairment

PROJECT_TITLE: Community-based amblyopia screening using a novel device


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Eye Disease and Disorders of Vision;Lung;Physical Injury - Accidents and Adverse Effects

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: Mustard gas (MG) is a chemical weapon of mass destruction that can lead to blinding disease of the eye and currently has no effective treatment. This grant proposes to study the role of oxygen, particularly the lack of it (hypoxia), in MG-related eye injuries. In addition, this grant will explore the efficacy of a topical oxygen therapy (supersaturated oxygen emulsion) in treating MG eye injury.

PI_NAMEs: YIN, JIA  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acceleration;Acute;Alkalies;Animals;Apoptosis;Atmosphere;Blindness;Bulla;Cataract;Cells;Chemical Injury;chemical threat;Chemical Weapons;Cornea;corneal epithelium;Corneal Neovascularization;cytokine;Data;Defect;Edema;effective therapy;efficacy evaluation;Emulsions;Enabling Factors;Engineering;Epithelial Cells;Equipment;Event;exposed human population;Exposure to;Eye;Eye diseases;Eye Injuries;Eyelid structure;Fibrosis;Fluorescein;Goals;Grant;healing;HIF1A gene;Histologic;Human;Hypoxia;Hypoxia Inducible Factor;In Vitro;in vivo;Inflammation;Inflammatory;Injections;Injury;Knowledge;Leucocytic infiltrate;limbal;mass casualty;Mechlorethamine;Mediating;mouse model;Mucous Membrane;Mus;Mustard Gas;neovascularization;nerve supply;novel;Oxidative Stress;Oxygen;Oxygen Therapy Care;Pain;Penetration;portability;pressure;Production;Proliferating;Research;Role;Signal Transduction;Skin Tissue;slit lamp imaging;Stains;stem cells;Structure of parenchyma of lung;targeted treatment;Temperature;Testing;Therapeutic;Time;Tissues;Topical application;Training;transcription factor;Treatment Efficacy;Visual impairment;weapons of mass destruction;Work

PROJECT_TITLE: Tissue Hypoxia and Topical Oxygen Therapy in Ocular Mustard Gas Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-F(54)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Hearing Loss;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: PORTLAND

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Narrative According to the World Health Organization prolonged noise exposure is responsible for more than one-third of hearing losses, however no biological cure currently exists. Anti-inflammatory drugs have been shown to ameliorate hearing decline caused by noise exposure, indicating that inflammatory cells such as macrophages may offer a therapeutic target. Completion of this project will further our knowledge of where macrophages in cochlea come from after noise damage and provide insights into how we can design strategies for reducing inflammation in an effort to cure hearing loss.

PI_NAMEs: AJAMI, BAHAREH  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acute;Adult;Age;Anatomy;Animals;Anti-Inflammatory Agents;Biological;Biological Process;Body System;Brain;Cell Therapy;Cells;cellular targeting;Characteristics;Cochlea;Collaborations;Data;design;Development;Disease;Disease Progression;drug discovery;effective therapy;Effectiveness;Embryonic Development;embryonic stem cell;experimental study;Exposure to;Future;Gene Expression;Gene Expression Profile;gene function;Genetic;Genetic Transcription;Growth;Hearing;hearing impairment;hearing loss risk;Heterogeneity;Homeostasis;Human;Immune;Inflammation;Inflammatory;Injury;insight;Intervention;Knowledge;Label;Labyrinth;Letters;Location;Macrophage;Maps;Modeling;Molecular;Molecular Profiling;Molecular Target;monocyte;Morphology;Mus;Noise;noise exposure;Noise-Induced Hearing Loss;normal hearing;old mice;Parabiosis;Pathogenicity;Pathology;Pathway interactions;Pharmaceutical Preparations;Phase;Play;Population;Prevalence;Property;Recovery;regenerative cell;Regenerative pathway;Resolution;response;Role;side effect;single-cell RNA sequencing;Steroids;Temporary Threshold Shift;Therapeutic Intervention;therapeutic target;Tissue-Specific Gene Expression;transcriptomics;Transgenic Organisms;Visit;Work;World Health Organization;young adult

PROJECT_TITLE: Investigating the origin and functional properties of immune cells in noise-induced hearing loss


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Patient Safety;Pregnancy;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative In Georgia, racial disparities in adverse maternal health outcomes, including severe maternal morbidity and maternal mortality, are wide and persistent. Equity-centered, transformational models of care offer promise for reducing these disparities and achieving maternal health equity, however, data sufficient for supporting the adoption of such models into health care practice are lacking. To fill this critical gap, we propose to complete an outcome and process evaluation within a pragmatic randomized controlled trial (RCT) of the integration of community-based patient navigators into the continuum of maternal care of Black women in a safety-net hospital system in metropolitan Atlanta, Georgia.

PI_NAMEs: CHANDLER, RASHEETA ;DUNLOP, ANNE LANG (contact);HERNANDEZ, NATALIE DOLORES

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: Address;Adoption;arm;Birth;Black race;black women;Caring;Chronic;Clinical;Communities;community based research;Community Health;cultural competence;Data;Data Reporting;depressive symptoms;design;Developed Countries;Discrimination;Disparity;disparity reduction;Dose;Effectiveness;effectiveness evaluation;Elements;Equity;ethnic minority;Evaluation;Event;evidence base;experience;Familiarity;Health;health care quality;health care service utilization;health equity;Health Personnel;Health Services;Health system;Healthcare;Hospitals;implementation intervention;implicit bias;Improve Access;improved;Inequity;informant;Institution;Institutional Racism;Intervention;intervention delivery;Interview;Life;Low income;Maternal Health;Maternal health equity;Maternal Health Services;maternal morbidity;Maternal Mortality;Measures;Mediator;meetings;Mental disorders;Methods;metropolitan;Modeling;Morbidity - disease rate;mortality;Mothers;multidisciplinary;National Institute on Minority Health and Health Disparities;Outcome;Participant;patient navigation;patient navigator;Patients;Perception;Perinatal;Policies;Politics;postpartum care;Postpartum Period;pragmatic trial;Pregnancy;Pregnancy Complications;Pregnancy Rate;prenatal;Prenatal care;prevent;preventable death;Preventive care;Primary Care;primary outcome;Process;process evaluation;Quality of Care;Questionnaires;Race;racial disparity;racial minority;racism;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;Resources;Review Committee;safety net;Sample Size;scale up;secondary outcome;severe maternal morbidity;Severities;Shapes;social;Social support;Stress;stress symptom;substance use;System;Testing;Time Management;Uninsured;Woman

PROJECT_TITLE: A Pragmatic Trial of Integrating Community-based Patient Navigation into the Continuum of Maternal Care for Black Women in a Safety-Net Health System: Effects on Maternal Health, Health Care, Morbidit


NIH_SPENDING_CATS: Aging;Bioengineering;Comparative Effectiveness Research;Data Science;Eye Disease and Disorders of Vision;Infectious Diseases;Machine Learning and Artificial Intelligence;Macular Degeneration;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Otitis Media;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The broad aim of this proposal is to develop novel statistical and machine learning methods and software to analyze studies with complex multivariate survival outcomes and high-dimensional covariates. The successful completion of the project will enhance the discovery of risk factors for disease progression, improve the individualized prediction of disease progression trajectories, and to increase the success of precision medicine.

PI_NAMEs: DING, YING  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Acute;Address;Age related macular degeneration;Algorithms;Alzheimer's Disease;Bilateral;Cessation of life;Clinical;Clinical Management;Collection;comorbidity;Complex;Computer software;computerized tools;Data;deep neural network;Development;Diagnostic;Disease;Disease Progression;disorder prevention;disorder risk;ear infection;Event;Eye;Eye diseases;flexibility;frailty;Future;Genetic;high dimensionality;high risk;hormone therapy;Image;improved;individualized medicine;innovation;Joints;Label;large scale data;Literature;loss of function;Machine Learning;machine learning method;Measures;Methodology;Methods;Modeling;Modernization;neural network;Neural Network Simulation;neuroimaging;novel;Observational Study;Otitis Media;Outcome;Patients;personalized predictions;personalized risk prediction;precision medicine;Prevention;primary endpoint;Procedures;randomized, clinical trials;Recommendation;Recurrence;Research;Risk;Risk Assessment;Risk Factors;semiparametric;Shapes;Software Tools;statistical and machine learning;Statistical Methods;statistics;Structure;Subgroup;success;survival outcome;Testing;therapy development;Time;treatment effect;Treatment Efficacy;treatment planning;trial design;Universities;Women's Health;Women's trial

PROJECT_TITLE: New statistical methods and software for modeling complex multivariate survival data with large-scale covariates

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative This application proposes to investigate the structure and dynamics of HIV-1 Env by integrating cryo- electron tomography (cryoET) and single-molecule Förster Resonance Energy Transfer (smFRET) imaging. A detailed understanding of the HIV-1 Env protein will inform antiviral therapies and vaccine design directed against HIV-1 Env.

PI_NAMEs: MOTHES, WALTHER H (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Adopted;Affect;Anti-viral Therapy;Antibodies;Antigens;Automobile Driving;Binding;Binding Proteins;Bulla;CCR5 gene;CD4 Antigens;Cell membrane;Cells;Cellular Membrane;Chimeric Proteins;Cholesterol;Chronic;Classification;Complex;Cryo-electron tomography;Data;data exchange;Development;env Gene Products;Environment;Fluorescence Resonance Energy Transfer;fluorophore;HIV;HIV Envelope Protein gp120;HIV-1;Image;Incubated;insight;instrumentation;Laboratories;Lipids;Mediating;Membrane;Membrane Fusion;Methodology;Methods;Molecular Conformation;Monitor;particle;Positioning Attribute;Process;Protein Conformation;Protein Dynamics;protein function;protein structure;Proteins;Protomer;receptor;Receptor Activation;Resolution;Sampling;single molecule;small molecule inhibitor;software development;Speed;Structure;Surface;System;T-Lymphocyte;Testing;therapy design;Vaccine Design;vaccine development;Vaccines;Viral;Viral Proteins;Virion;Virus;Virus-like particle;Visualization;Work

PROJECT_TITLE: HIV-1 Env protein structure and function assessed by parallel smFRET and cryoET

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Digestive Diseases;Hematology;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative: Allogeneic hematopoietic cell transplantation (HCT) is an effective therapy for a number of malignant and non- malignant blood and metabolic diseases. But its applicability has been limited by its most significant complication, gastrointestinal graft-versus-host disease (GI GVHD). Our proposal aims to understand the role of intestinal stem cells (ISC) metabolism and its impact on GVHD and in regulation of anti-leukemic responses.

PI_NAMEs: REDDY, PAVAN  (contact)

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: Allogenic;Autoimmunity;Bioenergetics;Biology;Butyrates;Cell Maintenance;Cell Therapy;Cells;Cellular Metabolic Process;Complex;Complication;Critical Pathways;Data;Defect;Development;effective therapy;Electron Transport;Epithelial Cells;gastrointestinal;Genetic;Glycolysis;Goals;graft vs host disease;graft vs leukemia effect;Hematological Disease;Hematopoietic Stem Cell Transplantation;Immune;Immunosuppression;insight;intestinal epithelium;Intestinal Graft Versus Host Disease;Intestines;Knockout Mice;leukemia;LGR5 gene;Maintenance;Malignant - descriptor;Mediating;Metabolic;Metabolic Diseases;Metabolism;metabolomics;microbial;Mitochondria;Morbidity - disease rate;mortality;Non-Malignant;novel;Organ;Organ Transplantation;Play;prevent;Propionates;Publishing;Regulation;resilience;response;Role;Seminal;Severities;Severity of illness;single cell sequencing;Solid;stem cell function;stem cells;Succinate Dehydrogenase;T-Lymphocyte;Technology;Testing;Tissues;tumor;Volatile Fatty Acids

PROJECT_TITLE: Intestinal tissue intrinsic mechanisms in regulation of GI GVHD

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: This study aims to develop a quantitative imaging technique of vascular stiffness and flow that can be integrated into conventional ultrasound scanners to inform neurologists and neurosurgeons regarding the stability of a detected carotid plaque detected and its propensity for stroke. This new technology may constitute an important tool for accurate carotid plaque staging and thus timely prevention of stroke.

PI_NAMEs: KONOFAGOU, ELISA E. (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Affect;American Heart Association;Anatomy;Animals;Arterial Fatty Streak;arterial stiffness;Biological Markers;Biomechanics;Biometry;Blinded;Blood flow;Blood Vessels;calcification;Carotid Artery Plaques;Cause of Death;Characteristics;Clinical;clinical practice;Detection;Diagnosis;diagnostic value;disability;elastography;Endarterectomy;Ensure;experience;falls;Family suidae;Fatality rate;Hemorrhage;high risk;Histologic;Hospitalization;Image;imaging biomarker;Imaging Techniques;in vivo;Intervention;intimal medial thickening;Ischemic Stroke;Lipids;Liquid substance;Magnetic Resonance Imaging;Maps;Mechanics;Medicine;Methodology;Modality;Morphologic artifacts;multidisciplinary;Neurologist;Neurology;Neurosurgeon;new technology;Operative Surgical Procedures;Pathology;Patients;Performance;Persons;Physiologic pulse;Pliability;porcine model;Property;quantitative imaging;Radiation;Radiology Specialty;Reader;Recurrence;Reporting;Risk;Risk Assessment;Role;Rupture;screening;simulation;Solid;Staging;statistics;Stenosis;Stroke;stroke event;stroke patient;Stroke prevention;stroke risk;stroke therapy;symptomatology;Systole;Techniques;Technology;Testing;tool;Ultrasonography;ultrasound;United States;Validation;vector

PROJECT_TITLE: Mechanical characterization of carotid plaques for stroke risk assessment

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: The Gene Ontology (GO) knowledgebase is the world’s largest source of information on the functions of genes, and is a foundation for computational analysis in biomedical research. Reac- tome is a popular resource that integrates information about the biological pathways that power all life on earth. The proposed work will better integrate content currently siloed in the two re- sources to provide a more fully interoperable open access resource for the biomedical research community.

PI_NAMEs: DEUSTACHIO, PETER G (contact);MUNGALL, CHRISTOPHER J;SMITH, CYNTHIA LOUISE;THOMAS, PAUL D.

PROGRAM_OFFICER_NAME: WELLINGTON, CHRISTOPHER

PROJECT_TERMS: Automated Annotation;Automation;Biochemical Reaction;Bioinformatics;Biological;Biological Models;Biological Process;Biomedical Research;biomedical resource;Caenorhabditis elegans;Chemicals;Chemistry;Collaborations;Communicable Diseases;Communities;Complex;Computer Analysis;Coupled;Data;data exchange;data mining;data resource;data standards;Databases;Development;digital;diverse data;Ensure;Foundations;Funding;gene function;gene product;Generations;Genes;Goals;Human;Human Biology;Individual;interoperability;knowledgebase;Laboratory mice;Life;Maps;Mediating;model organism;Modeling;Molecular;National Human Genome Research Institute;Nematoda;Ontology;open source;Pathway interactions;Planet Earth;Procedures;Process;protein complex;Protein Family;Proteins;prototype;Reaction;Research Personnel;Resources;Rhea;Source;System;tool;Translating;Validation;Work

PROJECT_TITLE: Reactome and the Gene Ontology: Digital pathway convergence for core data resources

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE Intestinal villi are finger-like projections that increase the intestinal absorptive surface area nearly 100-fold. Abnormalities in villi are found in many gastrointestinal maladies, such as inflammatory bowel and celiac diseases, and are also side effects of damage induced by radiation, chemotherapy, and infection. The regenerative process of villi is often impaired, and persistent villus atrophy can cause significant clinical challenges. In this application, we will determine forces and molecules that act in the mammalian embryo to shape the villi, which will aid in the design of new strategies to promote villus regeneration in vivo and to build replacement tissue ex vivo.

PI_NAMEs: GARTNER, ZEV JORDAN (contact);KLEIN, OPHIR D

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Actins;Adult;Architecture;Area;Artificial tissue;Atomic Force Microscopy;Atrophic;Automobile Driving;blebbistatin;Calcium Signaling;Celiac Disease;Cells;chemotherapy;Clinical;Computer Models;Connexin 43;Data;design;Development;driving force;Embryo;Endothelin;Endothelin Receptor;Engineering;Epithelium;Erinaceidae;experimental study;Fibroblasts;Fingers;Future;Gap Junctions;gastrointestinal;Genes;Genetic Transcription;Goals;Human;Impairment;improved;in vivo regeneration;Infection;Inflammatory Bowel Diseases;inhibitor;Injury;interfacial;intestinal epithelium;intestinal villi;Intestines;Investigation;live cell microscopy;Malabsorption Syndromes;Maps;Measurement;Measures;Mechanics;Mediating;Mesenchymal;Mesenchyme;Modeling;Molecular;monolayer;Morphogenesis;Morphology;Motility;Mus;Myosin Type II;Natural regeneration;non-muscle myosin;Nonmuscle Myosin Type IIA;novel therapeutics;Nutrient;Outcome;Pathway interactions;Patients;Pattern;Phase;Phosphorylation;Physical condensation;Play;Population;Process;programs;Proteins;radiation effect;Radiation induced damage;reconstitution;regenerative;Regenerative research;repaired;replacement tissue;Resolution;Role;Scientist;self organization;Shapes;side effect;Signal Transduction;single-cell RNA sequencing;Site;Small Intestines;Smooth Muscle;Smooth Muscle Myocytes;Source;Stains;Surface;Testing;Tissue Engineering;Tissues;uptake;Villus

PROJECT_TITLE: The physical and molecular mechanisms of intestinal villus morphogenesis and repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


NIH_SPENDING_CATS: Clinical Research;Estrogen;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: PROJECT NARRATIVE This R21 grant application proposes to characterize the effects of gender-affirming testosterone therapy for transgender men on the cellular and innate immunological properties, and susceptibility to HIV-1 infection of cervical mucosa. Using an ex vivo model of HIV-1 infection in cervical explant tissue derived from medically indicated hysterectomies, we anticipate identifying specific alterations in the cervical mucosa that correlate with hormone therapy and increased susceptibility to HIV-1. If successful, our findings will provide vital underpinnings for future studies focused on HIV-1 prevention strategies for trans men.

PI_NAMEs: KAPPES, JOHN CHRISTOPHER;OCHSENBAUER, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: DEY, BARNA

PROJECT_TERMS: adaptive immunity;Adult;Affect;Androgens;Anti-Inflammatory Agents;Applications Grants;assigned female at birth;Bacterial Vaginosis;Biological;cell type;Cells;Cervical;Characteristics;chemokine;cis-female;Community Participation;Coupled;cytokine;dehydroepiandrosterone;Development;Elasticity;Female;Frequencies;Future;gender affirmation;gender affirming hormone therapy;HIV;HIV-1;hormone therapy;Hormones;Hysterectomy;immune function;Immune response;Immunologics;Individual;Infection;innate immune function;Knowledge;Lactobacillus;Libido;Life Style;male;Masculine;Medical;Modeling;mucosal HIV infection;Mucous Membrane;Natural Immunity;Operative Surgical Procedures;Physiological;Population;Predisposition;Prevention strategy;Property;Reporting;Research;Research Proposals;Risk;Risk Factors;Sex Behavior;Sex Characteristics;steroid hormone;Symptoms;T-Lymphocyte;Testosterone;Tissues;Toll-like receptors;transgender;transgender men;transmission process;Vagina;vaginal dryness;vaginal lactobacilli;vaginal microbiome

PROJECT_TITLE: The effects of masculinizing gender-affirming hormone therapy for transgender men on susceptibility to HIV-1 infection modelled ex vivo in cervical mucosal tissue

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Genetics;Liver Disease;Nutrition

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Single-cell transcriptional profiling revealed that the liver is a heterogeneous tissue that consists of hepatocytes distributed in anatomical units, in which periportal hepatocytes are expected to favor fasting metabolism and pericentral hepatocytes tend to be involved in postprandial metabolism. This proposal has the potential to reveal important insight into the anatomical segregation of insulin signaling in the liver to control glucose and lipid metabolism. Understanding the regulation of insulin signaling at the spatial level might reveal the underlying mechanisms by which insulin fails to suppress hepatic glucose production but continues to activate lipogenesis during insulin resistance in humans.

PI_NAMEs: TAO, RONGYA  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Anatomy;blood glucose regulation;Candidate Disease Gene;Cells;Data;diabetic;Diet;Drug Targeting;Exhibits;experimental study;Fasting;Fatty Liver;Follistatin;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;Glucose;glucose metabolism;glucose production;Hepatic;Hepatocyte;High Fat Diet;Homeostasis;Human;Hyperglycemia;Hyperinsulinism;Hyperlipidemia;Impairment;in vivo;innovation;insight;Insulin;Insulin Receptor;insulin regulation;Insulin Resistance;insulin sensitivity;insulin signaling;Investigation;Knock-in Mouse;lipid biosynthesis;lipid metabolism;Lipids;Liver;liver metabolism;Lobule;LoxP-flanked allele;Maps;Mediator;Metabolic;Metabolic Control;Metabolism;Methods;Modeling;Molecular;mouse model;multitask;Mus;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organ;Pathogenicity;Pathologic;Patients;Physiological;Physiology;PIK3CG gene;prevent;programs;promoter;Proteins;Regulation;Regulatory Pathway;Role;segregation;Signal Transduction;Specificity;Time;Tissues;transcriptomic profiling;transcriptomics;Variant;Work

PROJECT_TITLE: Anatomical Regulation of Glucose and Lipid Metabolism by Insulin Signaling in Hepatocytes

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Clinical Research

PHR: These studies will investigate how manipulating the BCL10-MALT1 interaction, a critical protein-protein interaction in immune cells, affects lymphocyte function and impacts a subset of immune/inflammatory diseases. The applicant anticipates that this work will help to identify improved treatments for immune diseases that result from unrestricted MALT1 activity such as psoriasis and colitis. This career development award will provide the applicant with high-level training in lymphocyte biology and other aspects of immunology, thereby allowing her to launch a research career aimed at improving outcomes for patients with immune/inflammatory disease.

PI_NAMEs: MAURER, LISA M (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Achievement;Affect;Animal Model;Antigen Receptors;Antigens;Authorship;Autoimmune;Award;B-Lymphocytes;BCL10 gene;Biochemistry;Bioinformatics;biomedical scientist;Biometry;career;career development;Cells;Colitis;Complex;cytokine;Development Plans;Disease;disease model;Educational Status;Educational workshop;Environment;Event;Experimental Designs;Functional disorder;Goals;Grant;Growth;Immune;Immune System Diseases;immune system function;Immunoglobulin Domain;Immunology;improved;improved outcome;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;inhibitor;insight;K-Series Research Career Programs;Knowledge;Laboratories;Lymphocyte;Lymphocyte Activation;Lymphocyte Biology;Lymphocyte Function;lymphocyte proliferation;Lymphocyte Subset;Lymphoma;Malignant - descriptor;Malignant Neoplasms;Manuscripts;meetings;Mentors;Mentorship;Molecular;mouse model;Mucosa- associated lymphoid tissue lymphoma translocation protein-1;murine colitis;Mus;Organ;Pathogenesis;Pathology;Patient-Focused Outcomes;Peptide Hydrolases;pharmacologic;Phenotype;Physicians;Play;Positioning Attribute;Preparation;Production;Productivity;programs;Proliferating;Protease Inhibitor;Protein Biochemistry;protein complex;protein protein interaction;Proteomics;Psoriasis;Records;recruit;Regulatory T-Lymphocyte;Research;research and development;response;responsible research conduct;Role;scaffold;Scientist;Seminal;Signal Transduction;Signaling Protein;skills;small molecule;systemic inflammatory response;T-Lymphocyte;T-Lymphocyte Subsets;Technical Expertise;Techniques;Therapeutic;Training;transcription factor;Transcriptional Activation;transcriptomics;Universities;Work;Xenograft procedure

PROJECT_TITLE: BCL10-MALT1 protein-protein interaction in lymphocyte function and dysfunction

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Aging;Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Pediatric;Prevention

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: PROJECT NARRATIVE v Current pharmacological approaches to control ocular hypertension in open angle and congenital glaucoma can be effective, but are critically undermined by poor patient compliance, frequently leading to the development of sight-threatening complications, even in patients diagnosed early. This proposal aims to develop a recombinant adeno-associated virus (rAAV) vector-based approach to lower intraocular pressure permanently and safely following a single therapeutic intervention. In this proposal we will evaluate therapeutic effectiveness and safety of our gene therapy vector in 1) a mouse model of congenital glaucoma associated with Axenfeld-Rieger syndrome, and 2) in a canine model of open angle glaucoma; the data generated is expected to support translation for both human and veterinary use and provide strong evidence for the instigation of a phase I/II clinical trial.

PI_NAMEs: KOMAROMY, ANDRAS ;LIPINSKI, DANIEL MARK (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Abbreviations;Address;adeno-associated viral vector;Adherence;Anabolism;analog;Animal Model;Animals;Anterior;anterior chamber;Aqueous Humor;Axenfeld-Rieger syndrome;Blindness;canine model;Canis familiaris;Cell Reprogramming;Cells;Cessation of life;Clinic;Clinical;Clinical Management;clinical translation;Clinical Trials;clinically relevant;college;Complex;Cornea;Data;Defect;design;Development;Dinoprost;Disease;Disease Progression;Disintegrins;Dose;Drainage procedure;Early Diagnosis;Electrophysiology (science);Electroretinography;Ensure;Environment;Eye;Eye diseases;Eyedrops;Failure;Functional disorder;Future;gene therapy;Gene Transduction Agent;Genes;genetic architecture;Glaucoma;Health;Heterozygote;Homeobox;Human;human model;Hydrophthalmos;Inherited;Injections;Intervention;Laboratories;Lasers;Mediating;medical schools;medication compliance;Metalloproteases;Michigan;minimally invasive;Modeling;mouse model;Multimodal Imaging;Mus;Nature;nerve damage;Nerve Degeneration;Nerve Fibers;Neuropathy;normotensive;novel;Ocular Hypertension;Open-Angle Glaucoma;Operative Surgical Procedures;Ophthalmoscopy;Optic Atrophy;Optic Disk;Optic Nerve;optic nerve disorder;Optical Coherence Tomography;Outcome;Painless;Pathway interactions;Patient Compliance;Patients;Pharmaceutical Preparations;pharmacologic;Phase I/II Clinical Trial;Phenotype;Physiologic Intraocular Pressure;Pituitary Gland;prevent;Production;Prostaglandins;Publications;receptor;Recombinant adeno-associated virus (rAAV);Research;Research Personnel;Retina;Retinal Diseases;Retinal Ganglion Cells;Risk;Risk Factors;Safety;Scanning;Serotyping;targeted treatment;Technology;Testing;Therapeutic;therapeutic effectiveness;Therapeutic Intervention;therapy design;Thrombospondins;Tissues;Topical application;Trabecular meshwork structure;transgene expression;translational barrier;Translations;Treatment Efficacy;Treatment Protocols;Universities;Veterinary Medicine;Vision;Vision research;Visual Fields;Wisconsin;Work

PROJECT_TITLE: Development of an IOP-lowering gene therapy treatment for glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Nanotechnology;Prevention;Women's Health Research

PHR: Project Narrative Curative cancer surgery requires removal of all cancer cells - however 20-40% of the time, microscopic tumor cells are left behind, significantly increasing the chance of cancer returning. The goal of this project is to solve this problem through development of an ultrasensitive technology to visualize individual cancers cells in tissue and during surgery. It integrates nanotechnology, protein engineering, and advanced microscope design with the goal of intraoperative imaging of cancer cells with far greater sensitivity than available now.

PI_NAMEs: ANWAR, MEKHAIL  (contact);COHEN, BRUCE E

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: absorption;Address;Affinity;Alloys;Animal Model;Antibodies;antibody engineering;Antibody Specificity;Binding;Biological Assay;biomaterial compatibility;Breast Cancer Model;cancer care;cancer cell;Cancer Detection;cancer imaging;cancer risk;cancer subtypes;cancer surgery;Cell Culture Techniques;Clinical;Coupled;crosslink;Deposition;design;Detection;detector;Development;diagnostic platform;Diffuse;Disease;Engineering;Excision;fluorophore;G-substrate;Goals;Image;Image-Guided Surgery;imager;imaging modality;Imaging technology;Immunoglobulin G;improved;improved outcome;Individual;instrument;instrumentation;integrated circuit;Label;Lanthanoid Series Elements;Lasers;Left;light emission;Lymph Node Involvement;lymph nodes;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;meter;Microscope;Microscopic;microscopic imaging;Modeling;Modernization;molecular imaging;Mus;nano;nanocrystal;nanoparticle;Nanotechnology;Nature;neoplastic cell;new technology;novel;Operative Surgical Procedures;optical imaging;Optics;Outcome;Patients;Photons;pre-clinical;Protein Engineering;Proteins;Recombinants;Resectable;Residual Cancers;Residual Neoplasm;Sensitivity and Specificity;sensor;Silicon;Speed;Surface;Surgical Instruments;Surgical margins;Surgical Models;Technology;Testing;theranostics;Thinness;Time;Tissue imaging;Tissue Sample;Tissue Stains;Tissues;tool;Toxic effect;tumor;two-photon;Visible Radiation;Visualization;Xenograft Model

PROJECT_TITLE: Chip-Scale Intraoperative Optical Navigation with Immunotargeted Upconverting Nanoparticles


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The proposed research is relevant to public health because IgG antibodies are widely used therapeutically to treat cancer, autoimmune and inflammatory diseases, allergies, infectious disease, as well as transplantation. Although IgG1 is widely thought to be the most cytotoxic subclass, preliminary data shown in our application demonstrates that IgG4 can also become a cytotoxic antibody. The project is relevant to NIH's mission because they will establish basic immunology knowledge relating to how IgG its biological, cytotoxic activity, and will enable precise design of tailored effector functions for therapeutic immunoglobulins.

PI_NAMEs: ANTHONY, ROBERT MCCULLOUGH (contact);RAVETCH, JEFFREY VICTOR

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: anti-CD20;Anti-Inflammatory Agents;Antibodies;Antibody Therapy;antibody-dependent cell cytotoxicity;Autoantigens;Autoimmune Diseases;autoinflammatory diseases;B-Lymphocytes;Binding;Biological;Biological Assay;Biology;Biophysics;Blocking Antibodies;CD4 Positive T Lymphocytes;Cell-Mediated Cytolysis;Cells;Clinical;Communicable Diseases;Complement 1q;Complement-Dependent Cytotoxicity;Complex;cytotoxic;Data;defined contribution;design;Development;Disease;Dose;Effector Cell;empowerment;experimental study;Family;gain of function;Galectin 3;Glycoengineering;glycosylation;Goals;Human;Hypersensitivity;IgG Receptors;IgG1;IgG2;IgG3;IgG4;IgG4-related disease;Immune checkpoint inhibitor;Immunoglobulin G;Immunology;immunoregulation;Immunotherapeutic agent;In Vitro;in vivo;Inflammation;Inflammatory;innovation;insight;Intravenous Immunoglobulins;Knowledge;Laminin;Lesion;Malignant Neoplasms;Mediating;Mission;MS4A1 gene;Mus;neoplasm immunotherapy;Pathology;Patients;Phagocytosis;Plasma Cells;Polysaccharides;Post-Translational Protein Processing;programmed cell death protein 1;Public Health;receptor;receptor binding;Recombinant Immune Globulin;Regulation;Research;Resolution;Role;sialylation;Signal Transduction;standard of care;success;Testing;Therapeutic antibodies;Therapeutic Uses;translational impact;Transplantation;United States National Institutes of Health

PROJECT_TITLE: Examining IgG4 sialylation as a gain of function post-translation modification in IgG4-related diseases

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Genetic Testing;Genetics;Health Services;Human Genome;Patient Safety;Prevention

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE This proposal is relevant to public health because it will optimize the delivery of genetic testing and counseling services to cancer patients who are otherwise undertested and underdiagnosed with cancer predisposition. We will compare behavioral and patient reported outcomes of pretest Video Education with Result Dependent dIsclosure (VERDI) vs standard genetic counseling, to provide an evidence-based approach to modern cancer genetics care. We will evaluate the evolving role of genetic counselors as vital stakeholders in ensuring widespread implementation to expand access to genetics care.

PI_NAMEs: RANA, HUMA Q (contact)

PROGRAM_OFFICER_NAME: KULCHAK RAHM, ALANNA LEE

PROJECT_TERMS: Address;Age;Appointment;Behavioral;Breast;Cancer Center;cancer diagnosis;cancer genetics;Cancer Patient;cancer predisposition;Caring;cascade genetic testing;chatbot;Clinic;Clinical;Colorectal;Communication;Communities;community partners;Community Practice;cost;Cost Analysis;Costs and Benefits;Counseling;COVID-19 pandemic;Data;Diagnosis;Disclosure;Disease;disease-causing mutation;Education;Ensure;Environment;Epithelium;Evaluation;evidence base;Family;Family member;Fostering;Gender;Genetic;Genetic Counseling;genetic counselor;Genetic Services;genetic testing;Genomics;Germ Lines;Goals;Guidelines;Implementation readiness;Improve Access;improved;Individual;innovation;Insurance Coverage;Integrated Health Care Systems;interest;Intervention;Interview;Kidney;Knowledge;Malignant Neoplasms;Measurement;Measures;Medical;medical specialties;meetings;Melanoma;Methods;Minority;Modeling;Modernization;novel;Oncology;Operative Surgical Procedures;Outcome;Ovarian;Ovary;Pancreas;patient oriented;Patient Outcomes Assessments;patient safety;Patient-Focused Outcomes;Patients;personalized care;Probability;Process;Prostate;Provider;psychosocial;Public Health;racial diversity;randomized trial;Recommendation;Research;Resources;Role;safe patient;salivary assay;Sampling;Sarcoma;satisfaction;Schedule;service delivery;Service delivery model;Services;standard of care;Standardization;Structure;success;Surveys;System;targeted treatment;Technology;telegenetics;Test Result;Testing;testing uptake;trial comparing;tumor;uptake;virtual genetic counseling;Wait Time

PROJECT_TITLE: A Stakeholder Informed Randomized Trial of Pretest Video Education vs Standard Genetic Counseling for Cancer Patients: Evaluating the Impact on Patients, Providers and Practices


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The immune system governs responses to pathogens and vaccines, and deregulation of immune responses can lead to inflammatory and autoimmune diseases. This program will prepare outstanding scientists to study immune system development and regulation. This will ultimately foster advances in vaccine development and organ transplantation, as well as therapies and immunotherapies for autoimmune disease and cancer.

PI_NAMEs: ALLMAN, DAVID M (contact);OLIVER, PAULA MARIA

PROJECT_TITLE: Immune System Development and Regulation


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: DERMATOLOGY

PHR: PROJECT NARRATIVE The relevance of this grant proposal to public health lies in the fact that it is directed at training talented young investigators including physicians (MDs or MD/PhDs), talented MD/PhD or PhD predoctoral candidates, and PhD investigators to ultimately enter full-time academic careers in basic and/or clinical research and teaching in dermatology, thereby increasing our understanding of cutaneous (skin) biology, and our ability to more effectively treat a broad variety of skin diseases. The public health impact of skin disease is significant, with inflammatory disorders such as highly prevalent atopic dermatitis and psoriasis causing significant morbidity, and cutaneous malignancy causing both morbidity and mortality. It is critical to train new generations of skin disease researchers to more develop new approaches to diagnosis and treatment of such disorders.

PI_NAMEs: CHOATE, KEITH A;GIRARDI, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Dermatology;Training

PROJECT_TITLE: Training in Investigative Dermatology


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Older adults with Alzheimer's Disease and related dementia disorders are at increased risk of a motor vehicle crash due to impairment of the cognitive and sensory functions necessary for safe driving. There is substantial variation in the longitudinal risk of a crash both over time and across individual characteristics and the experience of a crash may alter the clinical course of disease, for instance by accelerating the transition to long term care. Current efforts to reduce the risk and consequences of a crash will be most effective if they can target sentinel points along the trajectory of crash risk where change is most likely.

PI_NAMEs: JOYCE, NINA  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Acceleration;Address;Affect;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Assisted Living Facilities;Automobile Driving;care outcomes;Caring;Characteristics;Clinical;Clinical Course of Disease;clinical diagnosis;Cognitive;comorbidity;Data;Data Sources;Dementia;Diagnosis;Disease;driving behavior;driving safety;Event;evidence base;experience;functional status;Goals;Health;health care service utilization;high risk;Hospitalization;Impaired cognition;Impairment;improved;Individual;individual variation;insurance claims;Intervention;Knowledge;Licensing;Link;Literature;Long-Term Care;Longitudinal trends;Masks;Measures;Medical;Medicare;Medicare claim;mild cognitive impairment;Modeling;New Jersey;novel;older adult;older driver;Outcome;Pattern;Patterns of Care;Phase;Policies;Population Study;Provider;psychologic;Reporting;Research;residential care facility;Risk;Risk Estimate;Risk Reduction;Safety;Sensory;Sentinel;Services;social;Source;Suspensions;Time;unsafe driving;Variant;Vehicle crash

PROJECT_TITLE: The risks and consequences of a motor vehicle crash in older adults with Alzheimer's Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PHR: Project Narrative The goal of this research is to better understand the impact of dysregulated transposable elements (TEs) within individual brain cells in people with and without Alzheimer’s disease (AD). The activation of TEs can lead to inflammation, autoimmunity, and genomic instability. We will examine the consequences of TE activation at multiple levels in different cell types in order to elucidate the underlying mechanisms at work, and explore how they are related to AD.

PI_NAMEs: LEE, EUNJUNG ALICE (contact);WALSH, CHRISTOPHER A.

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Age;age related;age related neurodegeneration;Aging;aging brain;aging process;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Animal Disease Models;Animal Model;Astrocytes;ATAC-seq;Autoimmunity;Autopsy;Brain;brain cell;Brain Diseases;cancer genome;CD8-Positive T-Lymphocytes;Cell Aging;Cell Culture Techniques;Cell Cycle;Cell division;Cell Nucleus;Cell Separation;cell type;Cells;Characteristics;Clonal Expansion;Collection;computerized tools;Computing Methodologies;Coupled;Data;Dependence;derepression;design;Development;DNA Double Strand Break;DNA Methylation;DNA Transposable Elements;Elderly;Elements;endonuclease;Epigenetic Process;epigenetic silencing;epigenomics;Event;examination questions;experimental study;Family;Gene Expression;genome sequencing;genome-wide;Genomic Instability;Genomics;Goals;Health;Heterochromatin;Host Defense;Human;Human Genome;Immune response;Individual;Infiltration;Inflammation;Innate Immune Response;Innate Immune System;Interphase Cell;Measures;Microglia;Nerve Degeneration;Neuroglia;neuroinflammation;Neurons;normal aging;novel;Oligodendroglia;overexpression;Pathway interactions;Peptides;Persons;Population;Prevalence;Protocols documentation;Recovery;Reporting;Research;response;Retrotransposition;RNA;Role;Sampling;single cell genomics;Sorting;Source;T cell infiltration;tau mutation;tau Proteins;Technology;Testing;Time;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;transcriptomics;transposon sequencing;tumor;Variant;whole genome;Work

PROJECT_TITLE: Role of transposon dysregulation in Alzheimer and aging brains revealed by single-cell genomic and transcriptomic analysis


NIH_SPENDING_CATS: Arthritis;Bioengineering;Biotechnology;Osteoarthritis;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Post-traumatic osteoarthritis (PTOA) is a type of joint disease that develops after joint injury, and there are currently no effective treatments to halt or reverse this debilitating condition. This research will study how inhibiting a specific signaling pathway, Wnt/β-Catenin signaling, can stop PTOA disease progression after joint injury. Since the exact biological mechanisms that cause PTOA are still poorly understood, this research will facilitate a greater understanding of the disease process and provide a direction for a potential treatment.

PI_NAMEs: MAERZ, TRISTAN  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Ablation;Advanced Development;Agonist;anti-depressive agents;Arthralgia;arthropathies;Attenuated;Benchmarking;beta catenin;Binding;Biocompatible Materials;Biological;biomaterial compatibility;Biomedical Engineering;bone;bone cell;Bone Spur;Cartilage;cartilage degradation;cell type;Cells;Chondrocytes;Clinical Trials;conditional knockout;Conditioned Culture Media;Data;delivery vehicle;Development;Disease;Disease Progression;Doctor of Philosophy;Dose;Drug Screening;effective therapy;efficacy testing;Engineering;Fibroblasts;Fibrosis;Formulation;G-Protein-Coupled Receptors;Gene Expression;Genetic Transcription;Glycolates;Histology;Human;Hypertrophy;IL6 gene;In Vitro;in vivo;Inflammatory;inhibitor;inhibitor therapy;Injections;Injury;Intra-Articular Injections;joint destruction;joint injury;Joints;Knee;knee pain;knee replacement arthroplasty;Knockout Mice;Leucine-Rich Repeat;LGR5 gene;Ligands;Literature;Local Therapy;Macrophage;Matrix Metalloproteinases;Mediating;Metabolic Clearance Rate;Microspheres;Molecular;Mus;novel;Operative Surgical Procedures;osteoblast differentiation;Osteoblasts;Osteogenesis;osteoprogenitor cell;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Peptide Hydrolases;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phenotype;Process;Rattus;receptor;Reporter;Research;Research Personnel;response;Role;Safety;safety assessment;Sclerosis;Severities;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule;solute;subchondral bone;Synovial Fluid;Synovial Membrane;Synovitis;Testing;Therapeutic;therapy development;Time;tissue regeneration;Tissues;TNF gene;Traumatic Arthropathy;WNT Signaling Pathway

PROJECT_TITLE: Sustained Biomaterial-mediated Inhibition of R-spondin 2 to Target Pathological Wnt Signaling in Post-Traumatic Osteoarthritis

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Patient Safety;Sleep Research

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Patients in the intensive care unit (ICU) frequently experience disturbed sleep which is thought to contribute to ICU delirium, an acute form of cognitive dysfunction that disproportionately increases the risk of both short and long-term neurocognitive morbidity which has a significant public health impact. The aim of this research is to investigate the role of sleep in the development of ICU delirium. Findings from this study will be used to inform sleep-promoting interventions to mitigate ICU delirium risk.

PI_NAMEs: CORDOZA, MAKAYLA  (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: Acute;Address;adequate sleep;Admission activity;Adrenal Cortex Hormones;Adult;Age;Agitation;Alcohol abuse;American;APACHE II;Award;Benzodiazepines;Cardiac Surgery procedures;career;Characteristics;Clinical;clinical care;cognitive function;cohort;Coma;common symptom;Communities;Complex;confusion assessment method;Critical Care;Critical Illness;Data;Delirium;Dementia;Demographic Factors;Development;Disease;Disorientation;Electroencephalography;Electronic Health Record;Environment;Environmental Risk Factor;Evaluation;Event;experience;Frequencies;Future;Goals;Health system;Heart;Home;Hour;human old age (65+);Hypertension;Hypotension;Impaired cognition;improved;improvement on sleep;inattention;Incidence;indexing;Individual;Intensive Care Units;Intervention;Learning;Length of Stay;Lighting;Link;Lung Transplantation;Measures;Mechanical ventilation;Medical Records;Memory impairment;Mentorship;modifiable risk;Morbidity - disease rate;mortality;neurochemistry;Neurocognitive;Neurodegenerative Disorders;Noise;novel strategies;observational cohort study;Operative Surgical Procedures;Outcome;Patient Care;patient oriented;Patients;Pennsylvania;Phase;Physiological;Polysomnography;Population;Postoperative Period;Predictive Factor;predictive modeling;primary outcome;programs;prospective;Public Health;REM Sleep;Research;Research Personnel;Risk;Risk Factors;Role;Scientific Advances and Accomplishments;Sedation procedure;skill acquisition;skills;Sleep;Sleep Apnea Syndromes;Sleep Architecture;Sleep Deprivation;Sleep disturbances;sleep quality;Structure;Survivors;Symptoms;Testing;Thoracic Surgical Procedures;Time;Training;Universities;wireless

PROJECT_TITLE: Evaluating the Role of Sleep in the Development of Intensive Care Unit Delirium

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(79)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lead Poisoning;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Project Narrative Lead (Pb) exposure is a significant public health concern in the US that can cause decrements in cognition, brain and behavior, and an extensive literature of research has shown that the burden of such toxicants is much heavier for individuals at the lowest end of the socioeconomic spectrum in the US. In earlier studies, we found that the association between brain structure and indices of socioeconomic status is much more pronounced among the poorest children, who are also likely to have the highest rates of exposure to Pb. In the large and diverse ABCD cohort, we have an opportunity to disentangle factors related to socioeconomic status from Pb exposure.

PI_NAMEs: SOWELL, ELIZABETH R (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affect;Archives;Area;Attention;Attenuated;Behavior;Behavioral;behavioral outcome;Biological Assay;Brain;Brain region;Child;Child Behavior Checklist;Child Health;Childhood;Cognition;Cognitive;cognitive development;cohort;cost;deciduous tooth;deprivation;Development;Dose;Education;Environment;Ethnic Origin;executive function;Exposure to;externalizing behavior;Family;fetal;Fetal Development;Funding;Future;Geographic Locations;Health;high risk;Home;Human;improved;in utero;Income;indexing;Individual;Intellectual impairment;Language;Lead;lead exposure;Lead levels;Life;Literature;low socioeconomic status;Maps;Measures;Mediating;Mediation;Metals;neighborhood safety;neural;neurodevelopment;neuropsychiatric disorder;neurotoxic;Neurotoxins;novel;Outcome;Parenting Education;Parents;Participant;Pathogenesis;Pattern;Perinatal;postnatal;prenatal;prenatal exposure;Problem behavior;Public Health;Race;recruit;Reporting;Research;Resources;Risk;Risk Factors;Sampling;Second Pregnancy Trimester;sex;Sex Differences;Site;Socioeconomic Status;socioeconomics;Structure;temporal measurement;Testing;Third Pregnancy Trimester;Time;Tooth structure;toxicant;Trees;United States National Institutes of Health;white matter

PROJECT_TITLE: Prenatal and Early Postnatal Lead Exposure on Childhood and Adolescent Brain, Cognitive and Behavioral Development

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE The number of autistic adults reached 5.4 million in the United States in 2017 and is projected to continue to rise, but evidence-based practices to optimize their health and well-being are limited and poor outcomes are common. This study will leverage existing infrastructure to finalize development of a novel support service provided by peers with lived experience, incorporating input from autistic peer specialists, autism researchers, peer support researchers, and experts in peer support training. We will then conduct a pilot randomized controlled trial to examine the effectiveness of the service while also examining feasibility, acceptability, and implementation procedures in preparation for future large-scale testing and dissemination.

PI_NAMEs: SALZER, MARK S.;SHEA, LINDSAY LAWER (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: acceptability and feasibility;Address;adolescent with autism spectrum disorder;Adoption;Adult;adult with autism spectrum disorder;Age;aged;Area;autism community;autism spectrum disorder;autistic;Certification;Childhood;Cities;Clinical;Clinical Trials;Communication impairment;Communities;Community Participation;community partners;comparison intervention;cost;Development;disability;Disease;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness-implementation RCT;effectiveness/implementation study;effectiveness/implementation trial;Employment;empowerment;Evaluation;evidence base;Evidence based intervention;Evidence based practice;experience;Family Relationship;feasibility testing;Feedback;Friendships;Funding;Future;Goals;Health;health determinants;Health Services Accessibility;high school;Housing;Hybrids;implementation facilitators;Individual;individuals with autism spectrum disorder;Infrastructure;inpatient service;interest;Intervention;Intervention Studies;Knowledge;Life;Lived experience;Loneliness;Manuals;Medicaid;Mental disorders;Mental Health;Modality;Motivation;Nature;novel;Occupations;Outcome;Participant;peer;peer support;Personal Satisfaction;Persons;Phase;Philadelphia;poor communities;Population;Population Heterogeneity;Positioning Attribute;Preparation;Prevalence;Procedures;Process;programs;Provider;Public Health;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;resilience;Resources;retention rate;Role;satisfaction;Self Determination;Self Efficacy;Services;severe mental illness;Signal Transduction;social;social engagement;Social Interaction;Social Network;social relationships;Social support;Social Values;Specialist;Structure;success;Supervision;Surveys;System;systematic review;Testing;therapeutic development;tool;Training;Training Support;transition to adulthood;Transportation;treatment as usual;United States;Work;young adult with autism spectrum disorder

PROJECT_TITLE: The effectiveness of an autistic-delivered peer-support intervention for autistic adults: Community Autism Peer Specialist (CAPS) program

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Colorectal Cancer;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Project Narrative Colorectal cancers (CRC) are among the leading causes of death from cancers in the US. Morphologically assessing excised tissue is the gold standard but requires fixation, staining, microscopy and pathology review, taking days and the information not being especially prognostic. This project develops an alternate technology based on chemical imaging evaluation that can provide an assessment within minutes, resulting in a new instrument, artificial intelligence methods for histology and microenvironment-powered prediction of disease course.

PI_NAMEs: BHARGAVA, ROHIT  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Analysis of Variance;analytical method;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence method;Benchmarking;cancer diagnosis;cancer imaging;Cancerous;Caring;Cause of Death;cell type;Cells;chemical addition;Chemicals;Clinical;Code;Collaborations;Colon;Color;Colorectal Cancer;colorectal cancer treatment;Complement;Computer software;Confusion;COVID-19;Custom;Data;deep learning;design;Detection;Disease;Dyes;Early Intervention;Electronics;Epithelial Cells;Excision;experience;follow-up;Foundations;Fourier Transform;Fresh Tissue;Future;Goals;high risk;Histocompatibility Testing;Histologic;Histology;Histopathology;human data;Image;Image Analysis;Imaging Device;imaging system;Imaging technology;Immersion;improved outcome;instrument;Laboratories;Laboratory Chemicals;Laboratory Technicians;lens;Logistic Regressions;Lymph Node Involvement;Machine Learning;Malignant Neoplasms;Measures;Methods;Microscope;Microscopy;Microtomy;Modeling;Modernization;Molecular;Molecular Analysis;Morphology;novel;Operative Surgical Procedures;Optics;Outcome;Pathology;pathology imaging;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Performance;Persons;Polyps;pre-clinical;prevent;Process;prognostic;prognostication;Property;Protocols documentation;Reagent;real-time images;Regression Analysis;Reporting;Research;Resources;Risk;ROC Curve;Route;rural setting;sample fixation;Sampling;screening;seal;Severity of illness;Solid;spectroscopic imaging;Spectroscopy, Fourier Transform Infrared;Speed;Staging;Stains;Statistical Methods;success;Surface;System;Techniques;Technology;technology platform;technology validation;Testing;Time;tissue fixing;Tissue Microarray;Tissues;tool;Training;Translating;translational clinical trial;tumor;tumor microenvironment;usability;Validation;Work

PROJECT_TITLE: Real time colon histopathology by infrared spectroscopic imaging

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Narrative There is continued need to train young researchers who will apply cutting-edge knowledge and interdisciplinary techniques to increase our understanding of the role of immunology and inflammation in infectious diseases, in cancer immunotherapy, and in chronic degenerative diseases such as Alzheimer’s Disease and muscular dystrophies. Following the COVID-19 pandemic, there is also an urgent need to understand protective immunity and the role of the immune system in mediating tissue damage to the lungs and disease severity. A T32 training grant will enable us to continue to provide opportunities for predoctoral students to develop expertise in multiple aspects of the immune response and support our ongoing very successful Immunology Training Program.

PI_NAMEs: PEARLMAN, ERIC  (contact)

PROJECT_TERMS: Grant;Immunology;Research Training

PROJECT_TITLE: Immunology Research Training Grant