ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Diabetes;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Chicago

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Impaired wound healing in type 2 diabetes (T2DM) is a problem of significant morbidity and cost. Inflammation informed mesenchymal stem cells derived extracellular vesicles (MSC EVs) play a significant role in enhanced bone repair and generation through its immunomodulatory potential. Using a translationally relevant and innovative dual delivery system with leucine zipper (LZ) peptide-based hydrogel and alginate beads, this application aims to evaluate the combinatorial use of engineered MSC EVs and growth factor as tools to enhance the rate and quality of bone repair in T2DM.

PI_NAMEs: HUANG, CHUN-CHIEH ;KANG, MIYA  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Acute;Adopted;Affect;Alginates;Anti-Inflammatory Agents;Antiinflammatory Effect;Biological Assay;BMP2 gene;bone;bone growth factor;bone healing;Bone Marrow;bone quality;Bone Regeneration;bone repair;Calcium;Calvaria;Characteristics;Chronic;Clinical;combinatorial;comparison control;Complex;controlled release;cost;crosslink;Cues;cytokine;Data;Defect;design;Diabetes Mellitus;diabetic;Diabetic mouse;Diameter;differential expression;Disease;Encapsulated;engineered stem cells;Engineering;Epidemic;extracellular vesicles;Failure;Foundations;Gel;Generations;Growth Factor;healing;Histology;Hydrogels;Immune response;Immune system;Immunohistochemistry;immunoregulation;Impaired wound healing;in vivo regeneration;Individual;Inflammation;Inflammatory;innovation;Kinetics;Knowledge;Leucine Zippers;Link;Macrophage;Mediating;Mesenchymal Stem Cells;Methods;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;overexpression;Paracrine Communication;Peptides;Phase;physical property;Physiological;Physiology;Play;Process;Property;Protocols documentation;Publishing;Quantitative Reverse Transcriptase PCR;Rattus;recombinant human bone morphogenetic protein-2;regeneration function;regenerative;RGD (sequence);Role;scaffold;self assembly;Signal Transduction;Standardization;System;Systemic disease;Testing;Therapeutic;Tissue Engineering;tool;Training;Treatment outcome;Vesicle;Weight;wound;wound healing

PROJECT_TITLE: Dual Delivery of Engineered EVs and Growth Factor for Bone Regeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTOLARYNGOLOGY

ORG_FIPS: US

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative This project is to study the cochlear micromechanical mechanisms underlying psychoacoustic phenomena by measuring the reticular lamina and basilar membrane vibrations and auditory nerve electrical responses in living cochleae. Results from this study will reveal novel mechanical mechanisms contributing to the pitch of missing fundamentals, psychophysical masking tuning curves, and gap detection. The knowledge gained from this study can be applied in clinics for diagnosing hearing loss in humans.

PI_NAMEs: REN, TIANYING  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acoustic Nerve;Action Potentials;Affect;Apical;Basilar Membrane;Clinic;Cochlea;Complex;Detection;Diagnosis;experimental study;fascinate;Frequencies;Gerbils;hearing impairment;Hearing problem;Human;improved;Inner Hair Cells;Knowledge;Location;Measurement;Measures;Mechanics;Motility;Music;Nerve Fibers;neural;Noise;novel;Outer Hair Cells;Patients;Pitch Perception;Procedures;Psychoacoustics;Psychophysics;response;Role;Scientist;Series;sound;Speech;Stimulus;Testing;vibration

PROJECT_TITLE: Cochlear micromechanical mechanisms underlying psychoacoustic phenomena

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-B(02)M]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Identifying environments as novel or familiar can influence memory and the formation of internal spatial maps, which may be impaired in aging, Alzheimer’s disease, and temporal lobe epilepsy. This proposal investigates a novel inhibitory projection from the hippocampus – a brain region involved in spatial memory and spatial maps – to the supramammillary area, which is a region which can signal spatial novelty. This proposal investigates if this novel projection can signal spatial recognition and suppress spatial novelty signals, providing insight into spatial processing and into hippocampal control of the supramammillary area.

PI_NAMEs: GLASSBURN, LAUREN  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Acute;Aging;Alzheimer's Disease;Alzheimer's disease model;Animal Model;Area;Behavior;Behavioral;Brain;Brain region;calcium indicator;Calcium Signaling;career;Cells;Coupled;Data;dentate gyrus;Development;Discrimination;Electrophysiology (science);Elements;Endoscopes;Environment;experimental study;Exposure to;Familiarity;Fiber;fluorescence imaging;Head;Hippocampus;Impairment;Implant;in vivo;in vivo calcium imaging;inhibitory neuron;Injections;insight;Knowledge;Label;Light;Location;Maps;Memory;memory encoding;memory recognition;Microscope;Minnesota;Mus;Neurons;Neurosciences;novel;object recognition;optical fiber;optogenetics;patient population;postsynaptic;Process;programs;Research;Research Personnel;response;Rodent;Rodent Model;Role;Shapes;Signal Transduction;skills;Slice;spatial memory;Statistical Data Interpretation;Technical Expertise;Techniques;Temporal Lobe Epilepsy;Testing;Training;University resources;Update;Viral;way finding;Work

PROJECT_TITLE: A novel hippocampal GABAergic projection and its potential role in spatial recognition


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT SUMMARY/NARRATIVE – OVERALL  We seek to understand the nature of the pial neurovascular circuit, whose dynamics are characterized by ultralow frequency oscillations near 0.1 Hz that parcellate into separate coherent regions across the cortical mantle. Our approach consists of studies on fundamentals, in terms of optical and MR imaging experiments with mice and theoretical studies of coupled oscillator modes, and applications to humans, in terms of single vessel resolution MR measurements and modeling of oxygen transport. We will use this knowledge to form a mathematical relation between the hemodynamic patterns observed in optical and functional magnetic resonance imaging experiments and the underlying brain state.

PI_NAMEs: DEVOR, ANNA  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Adopted;Affect;Analog Computers;analytical method;Area;arteriole;awake;Behavioral;Blood;Blood capillaries;Blood flow;Brain;Brain region;Cell Nucleus;central pattern generator;Collaborations;Computing Methodologies;constriction;Coupled;Coupling;Data;data acquisition;Data Analyses;Data Collection;data modalities;Dedications;Detection;Diameter;Education;Electroencephalography;Electrophysiology (science);Elements;Endothelium;Esthesia;experimental study;fascinate;Frequencies;Functional Magnetic Resonance Imaging;Generations;graduate school;hemodynamics;Homeostasis;Human;human subject;Image;in vivo;Individual;interest;Joints;Knowledge;Lead;Location;Locomotion;Logic;Magnetic Resonance Imaging;Mathematics;Measurement;Measures;Mechanics;Mediating;Microscopy;Modeling;Mus;Nature;network models;neural;Neuromodulator;Neurons;neuroregulation;Neurosciences;neurovascular;neurovascular coupling;optical imaging;Optics;Output;Oxygen;oxygen transport;Pattern;Periodicity;Phase;Physiology;Process;Publications;Recording of previous events;Regulation;Resolution;Rest;Science;Signal Transduction;Smooth Muscle;spatiotemporal;Spinal;Structure;Technology;Testing;Theoretical Studies;theories;Training;two-dimensional;Vascular blood supply;Vascular Endothelium;vasomotion;Vasomotor

PROJECT_TITLE: Local Neuronal Drive and Neuromodulatory Control of Activity in the Pial Neurovascular Circuit


NIH_SPENDING_CATS: Data Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PROJECT_TERMS: Advisory Committees;Agreement;Attention;Boston;California;Chicago;Collaborations;Data Science Core;Disputes;Ensure;Evaluation;Fostering;Funding;General Hospitals;Goals;Grant;Human Resources;IACUC;Illinois;Infrastructure;Institution;Institutional Review Boards;Intellectual Property;Lead;Leadership;Legal;Massachusetts;material transfer agreement;meetings;Names;Neurons;neuroregulation;neurovascular;Office of Administrative Management;operation;organizational structure;outreach;Procedures;programs;Progress Reports;Publications;Research;Research Activity;Rest;synergism;Universities;University adminstration;Update;Work

PROJECT_TITLE: Administration Core


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Cancer;Skin Cancer

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative This project aims to develop a new type of high-throughput digital cytopathology tool with intrinsic molecular contrast for label-free and slide-free histology. If successful, it will decrease the time to diagnosis/treatment via rapid onsite evaluation of biopsies and reduce the rate of re-excision surgeries for patients.

PI_NAMEs: ZHENG, GUOAN  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: absorption;Address;Adjuvant Therapy;Amino Acids;Anatomy;Area;biological research;Biopsy;Brain Neoplasms;Brightfield Microscopy;cancer imaging;Cell Nucleus;Cells;Chemicals;Code;code development;cost;Critical Care;Cytology;Cytopathology;Cytoplasm;Data;data acquisition;deep neural network;Devices;Diagnosis;diffraction of light;digital;Disease;Dyes;Elements;Engineering;Evaluation;Excision;Fine needle aspiration biopsy;Fluorescence;fluorescence microscope;Glass;Health;Histologic;Histology;histopathological examination;Histopathology;Hospitals;Hour;Image;Imaging Device;immunopathology;Individual;Intervention;Label;Laboratories;lens;Lighting;Lung;Maps;Measurement;Measures;Medicine;meter;Methods;Microscope;Modeling;Modern Medicine;Molecular;Morphology;Mus;Nucleic Acids;Operative Surgical Procedures;Optics;Pathologist;Pathology;Patients;Performance;Phase;Preparation;Process;Proteins;prototype;Quartz;Research Personnel;Resolution;Sampling;sensor;Signal Transduction;Site;Skin Neoplasms;Slide;Specificity;Specimen;Spectrum Analysis;Stains;success;Surgical margins;Surgical Oncology;System;Thick;Time;Tissue Sample;Tissues;tool;tool development;transmission process;tumor;ultraviolet;Ultraviolet Rays;Validation;Variant;virtual;Visible Radiation;Work

PROJECT_TITLE: Label-free digital cytopathology using deep-ultraviolet coded ptychography with intrinsic molecular contrast

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


PI_NAMEs: MISHNE, GAL  (contact)

PROJECT_TERMS: Certification;Computer software;computing resources;Data;data and analysis portal;Data Science;Data Science Core;Data Set;digital data;Image;Link;Magnetism;Metadata;Neurons;neuroregulation;neurovascular;Participant;performance site;Process;Publications;relational database;repository;Research Personnel;Role;Secure;System;Time;two-photon;Visualization software;web portal

PROJECT_TITLE: Data Science Core


NIH_SPENDING_CATS: Biomedical Imaging;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: KLEINFELD, DAVID  (contact)

PROJECT_TERMS: adaptive optics;Area;arteriole;Auditory;Automobile Driving;Behavioral;Blood;Blood capillaries;Blood flow;Brain;BRAIN initiative;Cerebrum;Communication;Cortical Column;Coupled;Data;Data Analyses;Diameter;Electrophysiology (science);Endothelial Cells;Energy-Generating Resources;Equilibrium;experimental study;Frequencies;Functional Magnetic Resonance Imaging;Homeostasis;Human;Image;in vivo optical imaging;Individual;Investigation;Lateral;Lead;lecture notes;Length;Magnetic Resonance Imaging;Measurement;Measures;Medial;Mind;Modality;model design;Modeling;Mus;muscle form;Nature;neuronal excitability;Neurons;neuroregulation;neurovascular;neurovascular coupling;Optics;optogenetics;Oxygen;oxygen transport;Pathway interactions;Pattern;Penetration;Periodicity;Phase;Physiological;Physiology;Play;programs;response;Rodent;Role;Sampling;segregation;Sensory;sensory stimulus;Smooth Muscle;spatiotemporal;Stimulus;System;Testing;theories;tool;Touch sensation;Training;two photon microscopy;two-dimensional;two-photon;vasomotion;Vasomotor;Vibrissae;Vision;Work

PROJECT_TITLE: Project 1


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Kidney Disease;Regenerative Medicine

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: In kidney epithelial repair cells renew by rapidly dividing and progressing through the cell cycle. This process requires dynamic cell shape changes which are controlled by the cellular actin cytoskeleton but how this works is not known. Based on our preliminary data, we will test a novel molecular mechanism whereby the actin regulator Rac1 maintains cell morphology during cell division and thereby promotes epithelial regeneration, knowledge which will aid in the development of new therapeutic targets in kidney disease.

PI_NAMEs: BOCK, FABIAN MAXIMILIAN (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 3-Dimensional;Actins;Actomyosin;Acute Renal Failure with Renal Papillary Necrosis;Apical;Architecture;Biological Process;CDC2 gene;Cell Culture Techniques;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Death;Cell division;Cell membrane;Cell Proliferation;Cell Shape;Cells;Cellular Morphology;Chronic Kidney Failure;Complex;Cyclin B;Cytoskeletal Modeling;Cytoskeleton;Data;Defect;Development;Duct (organ) structure;Ductal Epithelium;Dysmorphology;Electrolytes;Epithelial Cells;epithelial repair;Epithelium;epithelium regeneration;ERM protein;F-Actin;G2/M Transition;high resolution imaging;Histologic;Homeostasis;In Vitro;in vivo;Injury;Ischemia;Kidney;Kidney Diseases;kidney repair;Knowledge;laser capture microdissection;Lead;live cell imaging;M cell;Mechanics;Mediating;Mitosis;Mitotic;Modeling;Molecular;molecular dynamics;Morphology;mutant;Natural regeneration;new therapeutic target;novel;Nutrient;Obstruction;Optics;p21 activated kinase;Phosphotransferases;Play;pressure;Process;Proliferating;Proteins;renal epithelium;Renal tubule structure;repaired;Reperfusion Therapy;Resolution;rho GTP-Binding Proteins;Role;Shapes;spatiotemporal;superresolution imaging;Testing;tissue repair;Tissues;Tube;Tubular formation;Water;Work

PROJECT_TITLE: Rac1 and the actin cytoskeleton in renal tubular repair


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Hydrocephalus;Neurosciences;Rare Diseases;Stroke

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The central goal of the proposed project is to define how inflammation and the clinical morbidities associated with aneurysmal subarachnoid hemorrhage (SAH) can be mitigated with non-invasive vagus nerve stimulation, known as transcutaneous auricular branch vagal nerve stimulation (taVNS). The proposed research is relevant to public health because, given the substantial life-threatening morbidity of SAH, the development of a novel non-pharmacologic method that would be low risk and rapidly scalable would reduce the societal and personal burden of post-SAH morbidity. Thus, the proposed research is relevant to the NINDS mission, which is to develop knowledge about the brain and to use that knowledge to reduce the burden of the neurologic disease of hemorrhagic stroke.

PI_NAMEs: BRUNNER, PETER ;LEUTHARDT, ERIC CLAUDE (contact);ZIPFEL, GREGORY J

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: absorption;Acute;Adult;Aneurysmal Subarachnoid Hemorrhages;Angiography;Anti-Inflammatory Agents;Antiinflammatory Effect;Arthritis;Attenuated;Automobile Driving;Blood;Brain;Brain hemorrhage;Central Nervous System;Cerebral Edema;Cerebrospinal Fluid;Cerebrovascular Spasm;Chronic;Clinical;Clinical Trials;cohort;cytokine;Data;Death Rate;Development;Drainage procedure;effective intervention;Foundations;Functional disorder;Future;Goals;Hemorrhage;Hydrocephalus;IL18 gene;immunoregulation;implantation;improved outcome;Incidence;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory marker;Inflammatory Response;innovation;interleukin-23;Interleukin-6;Intervention;Intracranial Aneurysm;Knowledge;Life;Lifelong disability;Macrophage;Mediating;Methodology;Methods;Mission;Morbidity - disease rate;National Institute of Neurological Disorders and Stroke;Nature;Nerve;Nervous System Disorder;neuroregulation;Nonpharmacologic Therapy;novel;novel strategies;Operative Surgical Procedures;Outcome;Outcome Study;Pathway interactions;Patient-Focused Outcomes;Patients;Penetration;Pharmaceutical Preparations;pharmacologic;Physiological;Play;prospective;Public Health;randomized, controlled study;Randomized, Controlled Trials;Research;Risk;Role;Rupture;Ruptured Aneurysm;Sepsis;Serum;Shunt Device;side effect;Subarachnoid Hemorrhage;Subarachnoid Space;success;systemic inflammatory response;T-Lymphocyte;Testing;TNF gene;Translating;vagus nerve stimulation;Validation;Vasospasm;Ventricular;White Blood Cell Count procedure;Work

PROJECT_TITLE: Non-invasive vagus nerve stimulation to mitigate subarachnoid hemorrhage induced inflammation

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PROJECT_TITLE: Project 2


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE This proposal seeks continued funding for the University of Michigan Genome Science Training Program (GSTP). The goal of the GSTP is to train graduate students and postdoctoral fellows at the interface of the mathematical sciences and human genetics and genomics, a critical area of genome science in which well- trained individuals are in high demand and short supply.

PI_NAMEs: BOEHNKE, MICHAEL L (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TITLE: University of Michigan Training Program in Genomic Science


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The vestibular sensory system housed in the inner ear sends projections to a multitude of regions in the central nervous system; however, how aging impacts central vestibular pathways is poorly understood. In this study, we propose to rigorously determine using state-of-the-art computational image analysis techniques age-related changes in central vestibular structures, and the relationship with behavioral measures of central vestibular function. Findings from this study will be used to drive further critical research questions, including 1) Does vestibular loss contribute to the accelerated decline in cognitive ability and brain structure that occurs in individuals with cognitive impairment and Alzheimer’s disease; and 2) Can vestibular interventions for vestibular loss prevent/mitigate changes in central vestibular pathways?

PI_NAMEs: AGRAWAL, YURI  (contact);RATNANATHER, JOHN TILAK

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acceleration;Accounting;Adult;age related;age related changes;Aging;Alzheimer's Disease;analysis pipeline;animal data;Animal Model;Anterior;Arithmetic;Atrophic;Baltimore;Basal Ganglia;behavior measurement;Biomedical Engineering;Brain;Brain region;Cell Nucleus;Central Nervous System;Clinical;Clinical Skills;Cognitive;cognitive ability;cognitive process;cognitive skill;Complex;computer infrastructure;Data;Dorsal;emerging adult;Equilibrium;executive function;Gait;Grant;healthy aging;Hippocampus;Human;Image Analysis;imaging facilities;imaging science;Impaired cognition;Individual;Infrastructure;Intervention;Labyrinth;Link;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Modeling;Motion Perception;Motor;Motor Cortex;Names;National Institute on Deafness and Other Communication Disorders;Neuroanatomy;neurocognitive test;neuroimaging;novel;older adult;Pathway interactions;Performance;Peripheral;Physiology;Pilot Projects;Posture;Prefrontal Cortex;prevent;Public Health;putamen;Reflex action;Research;Sensory;sensory system;shape analysis;Signal Transduction;skills;Somatosensory Cortex;spatial memory;Structure;Techniques;Thalamic structure;Time;transmission process;Ventral Lateral Thalamic Nucleus;Vestibular function;Vestibular loss;Vestibular nucleus structure;vestibular pathway;vestibular system;way finding

PROJECT_TITLE: Impact of vestibular loss on central vestibular pathways in aging adults


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: ROSEN, BRUCE R (contact)

PROJECT_TERMS: Affect;anatomic imaging;Anatomy;Angiography;area striata;Arousal;Arteries;arteriole;behavior prediction;behavioral response;Blood;blood oxygen level dependent;Blood Vessels;Blood Volume;Brain;Cerebral cortex;cognitive performance;Contrast Media;Coupled;Coupling;Diameter;Electroencephalography;experimental study;ferumoxytol;Foundations;Frequencies;Functional Magnetic Resonance Imaging;hemodynamics;Human;Image;Imaging Device;imaging modality;Iron;Link;Maps;mathematical model;Measurement;Measures;Methods;Morphology;multimodality;Mus;neural;Neurons;neuroregulation;neurovascular;non-invasive imaging;novel;Pattern;phenomenological models;Photic Stimulation;Physiological;Predisposition;programs;Property;Resolution;response;retinotopic;Sensory;Signal Transduction;spatiotemporal;Stimulus;Testing;theories;Time;tool;Vascular Endothelium;vasomotion;Veins;Venous;venule;visual stimulus;Work

PROJECT_TITLE: Project 3


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Narrative  The proposed research aims to understand the role of peer victimization (PV) in alcohol and other substance use outcomes among sexual minority adolescents. A mixed methods approach will be used to identify the proximal, longitudinal and situational conditions under which PV contributes to substance-use related outcomes. Public health implications of the study include informing the development of empirically- supported and tailored interventions to reduce PV and associated health disparities in this vulnerable population.

PI_NAMEs: HEQUEMBOURG, AMY L (contact);LIVINGSTON, JENNIFER A

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Acute;Adolescence;Adolescent;Adult;adverse outcome;Age;Aggressive behavior;Alcohol abuse;alcohol and other drug;Alcohol consumption;alcohol use initiation;Alcohols;assault;Attitude;Belief;Buffers;bullying;coping;Cross-Sectional Studies;cyberbullying;Data;design;Development;diaries;Disclosure;Disparity;Drug usage;emotion dysregulation;emotion regulation;emotional distress;Event;experience;Female;Gender Identity;General Population;harassment;Health;health disparity;Heterosexuality;Heterosexuals;high risk;Homophobia;improved;insight;Intervention;intervention program;Interview;Knowledge;Lesbian Gay Bisexual;Lesbian Gay Bisexual Transgender Queer;life span;Link;Literature;Longitudinal Studies;Longitudinal Surveys;Mediation;Mental Health;Methods;minority stress;minority subjects;Modeling;negative affect;nicotine use;novel;Outcome;Participant;Pathway interactions;Pattern;peer;peer victimization;physical conditioning;Population;Populations at Risk;preservation;Prevention program;Primary Prevention;Process;prospective;protective factors;psychologic;psychosocial;Psychosocial Factor;Public Health;public health priorities;Qualitative Research;queer;racial diversity;Random Allocation;Reporting;Research;Risk Factors;Role;Sampling;Sex Orientation;Sexual Harassment;sexual identity;sexual minority;sexual minority group;sexual minority stress;sexual minority youth;social;social norm;Social Perception;stressor;Students;Substance abuse problem;substance use;Surveys;theories;therapy development;Time;United States National Institutes of Health;verbal;Victimization;Vulnerable Populations;Youth

PROJECT_TITLE: Peer Victimization and Risky Alcohol Use among Sexual Minority Youth: Understanding Mechanisms and Contexts

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Lung;Pulmonary Hypertension;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative: Pulmonary arterial hypertension (PAH) is an incurable and fatal disease. There is a critical need to develop new therapies that effectively halt and reverse the disease by targeting the cellular and molecular mechanisms underlying the pathophysiology of PAH. The long-term goal of this project is to elucidate pathogenic mechanisms in PAH and develop novel curative therapies for this disease.

PI_NAMEs: KLINGER, JAMES RAYMOND;LIANG, OLIN D. (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Adult;Affect;angiogenesis;Binding;biobank;Bone Marrow;CD34 gene;Cells;cellular targeting;cohort;curative treatments;Data;Defect;Development;Disease;Disease Progression;Distal;Endothelial Cells;endothelial regeneration;Endothelium;Enhancers;Europe;fetal;Functional disorder;Gene Expression;Gene Mutation;gene repression;genome sequencing;Goals;Heart Hypertrophy;Hematopoietic;Human;hypoxia-induced pulmonary hypertension;Impairment;induced pluripotent stem cell;inhibitor;innovation;Intracranial Aneurysm;Japan;Knockout Mice;Lentivirus;Life;loss of function mutation;LoxP-flanked allele;Lung;lymphoblastoid cell line;Maintenance;Mediating;Mediator;migration;Molecular;mortality;Mus;mutant;Mutation;novel;novel therapeutics;overexpression;Pathogenesis;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Predisposition;prevent;programs;Progressive Disease;Proliferating;proliferative diabetic retinopathy;Proto-Oncogene Protein c-kit;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary Circulation;Pulmonary Hypertension;Pulmonary Pathology;Pulmonary Vascular Resistance;Recovery;Repression;response;retinal angiogenesis;right ventricular failure;Rodent Model;RUNX1 gene;Sampling;Signal Pathway;Signal Transduction;SOX17 gene;stem cells;symptomatic improvement;Techniques;Testing;Tissues;transcriptome sequencing;transcriptomics;Up-Regulation;Vascular Diseases;vascular injury;Vascular remodeling;whole genome;Wild Type Mouse

PROJECT_TITLE: SOX17/RUNX1 Axis Regulates Endothelial Cell Fate in the Pathogenesis of Pulmonary Arterial Hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cerebrovascular;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: LINNINGER, ANDREAS A (contact)

PROJECT_TITLE: Project 4


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Genetics;Neurosciences;Nutrition

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

PHR: Insects transmit a wide variety of diseases to hundreds of millions of people each year, and the geographic ranges of some of these diseases have been increasing. Many of these insects rely on their chemosensory systems to identify their human hosts, their food, and their mates. This project is designed to elucidate how these systems operate and could lead to new means of manipulating them so as to control these insect vectors of disease.

PI_NAMEs: CARLSON, JOHN R (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Ablation;Afferent Neurons;Aggressive behavior;Animals;Behavior;behavioral response;Biological Models;Code;combinatorial;Dependence;design;Development;Dimensions;Disease;disease transmission;Dose;Drosophila genus;Drosophila melanogaster;Environment;Exhibits;experimental study;Food;genetic analysis;Geography;Goals;Grant;Human;human disease;Individual;Insect Control;insect disease vector;Insect Repellents;Insect Vectors;Insecta;insight;Leg;Libido;Logic;Maps;Measures;Mediating;methyleugenol;Molecular;Molecular Analysis;Molecular Genetics;mutant;Neurons;Odors;Olfactory Pathways;Operative Surgical Procedures;optogenetics;Organ;Oviposition;Partner in relationship;Perception;Persons;Pheromone;Physiological;preference;receptor;response;Role;Sensory;Sensory Receptors;sensory system;Smell Perception;System;Taste Buds;Taste Perception;taste system;Testing;Thinking;Time;transmission process;Volatilization

PROJECT_TITLE: Genetic and Molecular Analysis of Olfaction

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Genetics;Human Genome;Mental Health;Neurosciences;Pediatric;Precision Medicine;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project applies a recent methodological breakthrough in functional magnetic resonance imaging (fMRI) to investigate genetic contributions to the organization of human brain networks, such as central executive networks, whose functions are critical to a variety of clinical and developmental outcomes. Identifying genetic loci that influence the development of personalized functional brain networks and contribute to psychiatric risk will lead to novel mechanistic insights into network dysfunction in mental illnesses, improved classification of at- risk individuals, and the potential for targeted neuromodulation guided by individualized neurogenetics.

PI_NAMEs: ALEXANDER-BLOCH, AARON FELIX (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: 22q11;Acceleration;Adolescence;Adolescent;Adult;Age;Anatomy;Area;association cortex;Atlases;Award;Behavioral;behavioral health;biobank;Brain;brain size;Candidate Disease Gene;career;case control;Childhood;Classification;Clinical;Clinical Trials;Cognition;Cognitive deficits;cognitive development;cohort;Communities;Copy Number Polymorphism;Data;Data Set;Detection;Development;developmental genetics;DiGeorge Syndrome;executive function;functional genomics;Functional Imaging;Functional Magnetic Resonance Imaging;functional outcomes;Future;gene network;Genes;Genetic;genetic architecture;genetic association;Genetic Risk;Genetic study;Genetic Variation;Genome;genome wide association study;genomic locus;Genomics;Goals;Heritability;Human;image processing;imaging genetics;improved;Individual;Informatics;Inherited;innovation;insight;Investigation;Joints;life span;Machine Learning;Magnetic Resonance Imaging;Maps;Measures;Mental disorders;Mental Health;Methodology;Methods;Modeling;network dysfunction;Neuroanatomy;neurodevelopment;neurogenetics;neuroregulation;novel;older adult;open data;Outcome;Participant;Persons;Phenotype;Physicians;precision genetics;Psychopathology;Reporting;Reproducibility;Research;Risk;risk variant;Sampling;Scientist;sensory cortex;sex;Site;SNP array;Standardization;Surface;Syndrome;Testing;Time;tool;transcriptome;Translational Research;Twin Multiple Birth;Variant;Work;Youth

PROJECT_TITLE: The Genetics of Personalized Functional MRI Networks


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Comparative Effectiveness Research;Cost Effectiveness Research;Genetic Testing;Genetics;Human Genome;Precision Medicine;Prevention

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE  Next-Generation DNA sequencing is now widely used in clinical oncology to detect mutations in cancers that inform prognosis and therapeutic options, but is limited in its sensitivity for low-prevalence mutations. This proposal outlines the development and validation of inexpensive, efficient, and ultrasensitive methods for detecting cancer-relevant mutations in clinical specimens. These technologies will be immediately translatable and practical for clinical diagnostics, and will provide enhanced capabilities in a broad range of applications, including the identification of emerging cancer subclones and ultrasensitive screening for the emergence or recurrence of malignancy.

PI_NAMEs: SALIPANTE, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: Accreditation;Address;Adoption;Alleles;analysis pipeline;anti-cancer research;Base Sequence;Bioinformatics;bioinformatics pipeline;bioinformatics tool;Biological;Biological Assay;Bypass;cancer cell;Cancer cell line;Cancer Detection;Cancer Patient;cancer therapy;cell free DNA;Characteristics;CLIA certified;Clinical;clinical diagnosis;clinical diagnostics;clinical material;Clinical Oncology;clinical practice;clinically actionable;clinically relevant;Community Clinical Oncology Program;Consensus;Consensus Sequence;cost;cost effective;cost effectiveness;data analysis pipeline;design;Detection;detection method;Development;Diagnostic;diagnostic value;Disease;DNA;DNA sequencing;Drug resistance;Event;Exhibits;exome;Formalin;Frequencies;Fresh Tissue;Gene Targeting;Genes;Genome;Genomics;Genotype;Goals;improved;Individual;innovative technologies;insertion/deletion mutation;interest;Label;Laboratories;Laboratory Research;Libraries;Ligation;Link;Low Prevalence;Malignant Neoplasms;Measures;Mediating;Methodology;Methods;Molecular;Monitor;Monitoring for Recurrence;mutant;Mutation;Mutation Detection;Neoplasms;neoplastic cell;next generation;next generation sequencing;Noise;novel;Nucleotides;Oncology;Output;Performance;precision medicine;Procedures;Prognosis;prognostic;Property;Protocols documentation;rare cancer;Recurrence;Relapse;research clinical testing;research study;Residual Cancers;Residual state;Resistance;resistance mutation;Sampling;screening;Screening for cancer;sequencing platform;Somatic Mutation;Specificity;Specimen;Techniques;Technology;Therapeutic;tissue fixing;Transposase;tumor;uptake;Validation;Variant;variant of interest;whole genome;Work

PROJECT_TITLE: Efficient, cost-effective, and ultrasensitive sequencing of somatic mutations


NIH_SPENDING_CATS: Genetics;Nutrition;Obesity

ORG_CITY: LITTLE ROCK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE This study will clarify how the obese state impacts gene expression in anterior pituitary somatotropes, including remodeling that may result in suppression of normal function. The study will determine how this suppressed state may impact responses to environmental stress and identify the regulatory pathways that may be compromised. The study will introduce state-of-the-art technologies, which present a unique opportunity for mechanistic insights that are critical to identify targets for therapeutic intervention in the obese state.

PI_NAMEs: CHILDS, GWEN V (contact);MACNICOL, ANGUS M;MACNICOL, MELANIE C

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Address;Adult;adult obesity;Animals;Anterior Pituitary Gland;Anterior Pituitary Hormones;Attenuated;Biological;Biological Assay;blood glucose regulation;Body Weight decreased;Cell Maturation;cell type;Cells;cohort;Desire for food;diet-induced obesity;Disease;energy balance;environmental stressor;Exposure to;Fatty acid glycerol esters;Functional disorder;Gender;Gene Expression;Gene Expression Profile;genetic regulatory protein;Goals;growth hormone deficiency;Hormonal;Hormone secretion;Hormones;Hyperinsulinism;improved;insight;insulin regulation;Knowledge;Laboratories;Leptin;leptin receptor;Light;Mediating;Mediator;Messenger RNA;Metabolic;Metabolic dysfunction;Metabolic stress;miRNA expression profiling;Molecular;Morbid Obesity;mouse model;mRNA Translation;Mus;natural hypothermia;Obese Mice;obese person;Obesity;Pathway interactions;Pattern;Pituitary Gland;Play;Post-Transcriptional Regulation;posttranscriptional;Prevalence;Production;Proteins;Recovery;Regulation;Regulatory Pathway;Research;Resistance;response;sensor;sex;Sex Differences;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Somatotrope Cell;Somatotropin;stem;stem cell biomarkers;stem cell population;stem cells;Stress;targeted treatment;Technology;Testing;Therapeutic Intervention;transdifferentiation;United States National Institutes of Health;Weight

PROJECT_TITLE: The Impact of Obesity on Somatotrope Function

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative  Sporadic Alzheimer's disease (AD) is a major age-related health concern in the US. Single-cell epigenomic profiling of AD vulnerable brain regions in the sporadic natural AD models (degus and dogs) is of high impact. The proposed work will generate invaluable resources for facilitating molecular and circuit studies of sporadic AD by other investigators in the field.

PI_NAMEs: REN, BING ;XU, XIANGMIN  (contact)

PROGRAM_OFFICER_NAME: MORO, MANUEL H

PROJECT_TERMS: 9 year old;abeta accumulation;Acceleration;Age;age related;age related decline;aged;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;American;Anatomy;Animal Disease Models;Animal Model;Animals;Astrocytes;ATAC-seq;Atlases;Behavior;behavior measurement;behavioral impairment;Biological Assay;Brain;brain cell;Brain region;Canis familiaris;Categories;Cell Nucleus;cell type;Cells;Cerebral Amyloid Angiopathy;Chilean;ChIP-seq;Chromatin;Cognitive;comparative;Complement;computational pipelines;Data;data modeling;Data Set;data sharing;Databases;Dementia;Development;Disease;Disease associated microglia;DNA;DNA Methylation;DNA methylation profiling;Enhancers;Epigenetic Process;epigenome;epigenomic profiling;epigenomics;Exhibits;frontal lobe;Gene Expression;Genes;Genetic Markers;Genome;genome-wide;genomic data;Goals;Health;Hi-C;Hippocampus;histopathological examination;Human;human disease;human old age (65+);hyperphosphorylated tau;Impaired cognition;improved;insight;Joints;Knock-in;Late Onset Alzheimer Disease;Ligation;Maps;Methods;Modeling;Molecular;Molecular Target;mouse model;multiple omics;Mus;Mutation;Nerve Degeneration;neural circuit;Neurons;neuropathology;novel therapeutics;Octodon;Octodon degus;older adult;Pathogenesis;Pathologic;Prefrontal Cortex;promoter;Publishing;Recording of previous events;Regulatory Pathway;repository;Research;Research Personnel;Resolution;Resources;Rodent;Sampling;Senile Plaques;single cell genomics;single nucleus RNA-sequencing;Technology;Testing;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Mice;Transgenic Organisms;translational potential;United States National Institutes of Health;validation studies;Variant;Work

PROJECT_TITLE: Comparative Single-Cell Epigenomic Analysis of AD-like Pathogenesis in Unconventional Animal Models


ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: Pulmonary arterial hypertension (PAH) is a life-threatening disease that affects predominantly females of childbearing age characterized by progressive small vessel loss and right heart failure. Most current therapies work by dilating blood vessels, but no treatments have been found that can restore angiogenesis and prevent loss of small vessels. The research project presented here aims at demonstrating that Wnt7a/ROR2 is a major orchestrator for cardiopulmonary angiogenesis and its loss contributes to small vessel loss and right heart failure in PAH.

PI_NAMEs: DE JESUS PEREZ, VINICIO A (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Adherens Junction;Affect;angiogenesis;Animal Model;Blood capillaries;Blood Vessels;Cardiopulmonary;Cardiovascular system;Cell Differentiation process;Cell Extracts;Cell model;cell motility;Cells;chromatin immunoprecipitation;Clinical;Complex;Cytoplasmic Tail;density;Disease;DNA;DNA Methylation;Echocardiography;Endothelial Cells;endothelial dysfunction;Endothelium;Epigenetic Process;epigenetic regulation;Equilibrium;exosome;Female of child bearing age;Fluorescence Resonance Energy Transfer;Focal Adhesions;gene-editing approach;Genetic;Genetic Transcription;Goals;Histone Acetylation;Histone Deacetylation;Human;Hypermethylation;Hypoxia;Hypoxia Inducible Factor;improved;Integrins;KDR gene;Knockout Mice;Life;Ligands;Lung;lung microvascular endothelial cells;lung pressure;Measures;Messenger RNA;Microfluidics;Modeling;Molecular;Morphogenesis;Mus;novel;Outcome;Output;Pathogenesis;Pathologic;Pathway interactions;Patients;Permeability;Phosphorylation;planar cell polarity;prevent;Process;Proteins;Proteomics;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary Hypertension;pyrosequencing;Rattus;Receptor Protein-Tyrosine Kinases;Recombinants;Recovery;Regulation;Repression;Research Project Grants;response;restoration;right ventricular failure;Right Ventricular Function;Role;sensor;Signal Transduction;Supplementation;Testing;Therapeutic;therapeutic evaluation;Tissues;Vascular Endothelial Growth Factors;Vascular Endothelium;Vascular remodeling;VEGFA gene;Ventricular;Work

PROJECT_TITLE: The Wnt7a/ROR2 axis in the pathogenesis of pulmonary arterial hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(05)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: MADISON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Parkinson disease devastates individuals by disrupting vocal communication and significantly impacts health and quality of life, even in the early stages of the disease. While the prevalence of voice deficits in this population is high, little is known about the mechanisms leading to these deficits, and treatment is often ineffective. This research uses both an in vivo animal model and in vitro larynx muscle and brainstem cell culture to study whole biological pathways, molecular targets, and small-molecule therapeutics to identify new treatments for Parkinsonian vocal communication dysfunction.

PI_NAMEs: KELM-NELSON, CYNTHIA A (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Acoustics;Address;Affect;Age Months;Animal Model;Animals;Behavior;Biochemistry;Biological;Brain Pathology;Brain Stem;brain tissue;Caring;Catalogs;Cell Culture Techniques;Central Nervous System;Clinical;Clinical Trials;clinically relevant;Communication;Communication impairment;Data;Data Set;density;differential expression;Disease;disease diagnosis;Disease Progression;Dopamine;drug candidate;Drug Kinetics;drug repurposing;Drug Screening;drug standard;Drug usage;Dysarthria;Dysphonia;early onset;Exhibits;experience;experimental study;FDA approved;Female;Functional disorder;functional outcomes;Future;Gene Expression;Gene Targeting;Genes;Genetic;Genetic Transcription;genetic variant;Goals;Health;Human;Human Genetics;human subject;Idiopathic Parkinson Disease;Image;improved;In Vitro;in vivo;Individual;innovation;Knock-out;Knowledge;Laryngeal muscle structure;Larynx;male;Maps;Measures;Methodology;Modeling;Molecular;Molecular Target;Motor Neurons;Motor Pathways;Nerve Degeneration;Nervous System;Neural Pathways;Neuroanatomy;Neurons;novel;novel therapeutics;Outcome;Parkinson Disease;Parkinsonian Disorders;Pathology;Pathway interactions;patient population;Patients;Peripheral;Peripheral Nervous System;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiological;PINK1 gene;Population;Prevalence;prevent;Production;public health relevance;Quality of life;Rattus;Refractory;Research;response;Rodent Model;Science;Series;sex;single-cell RNA sequencing;small molecule therapeutics;Social Interaction;Structure;System;targeted treatment;Techniques;theories;Therapeutic;Therapeutic Effect;three-dimensional modeling;Time;Tracer;Transcript;transcriptome sequencing;vocal cord;vocalization;Voice;Work

PROJECT_TITLE: Pathways, mechanisms, and treatments of vocal communication deficits in a Parkinson rat model

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Genetics;Heart Disease;Muscular Dystrophy;Pediatric;Pediatric Cardiomyopathy;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE This project is relevant to public health because Duchenne muscular dystrophy (DMD) heart failure is ubiquitous and deadly, however there is a limited understanding of early disease progression due to the lack of relevant human models resulting in no current effective treatments to prevent or limit disease progression. This proposal is designed to allow Dr. Forum Kamdar, an early status investigator, pursue new research directions in cardiac tissue engineering and precise gene editing through the Stephen I. Katz Early Stage Investigator mechanism to develop a 3D DMD heart model using heart cells derived from DMD patient skin cells to understand how the disease progresses with application of force and if these changes can be stopped by correcting the mutation. This research is in tight alignment with NHLBI’s mission to promote the prevention and treatment of heart diseases and enhance the health of all individuals so that they can live longer and more fulfilling lives by identifying the early causes for DMD cardiomyopathy disease progression, test dystrophin gene editing, and to ultimately develop effective, disease-specific treatments to prevent DMD cardiomyopathy.

PI_NAMEs: KAMDAR, FORUM D (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: 3-Dimensional;3D Print;Acceleration;adrenergic stress;base editing;bioink;Biological Models;bioprinting;Calcium;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiomyopathies;career;Cell Line;Cells;clinically significant;Complex;CRISPR/Cas technology;Cytoskeleton;design;Development;Disease;Disease Progression;Duchenne cardiomyopathy;Duchenne muscular dystrophy;Dystrophin;Early identification;early satiety;effective therapy;exon skipping;Extracellular Matrix;functional restoration;gene-editing approach;Generations;Genes;Genetic Transcription;Glycoproteins;Goals;Health;Heart;heart cell;Heart Diseases;Heart failure;Heart Injuries;Homeostasis;Human;human disease;human induced pluripotent stem cells;human model;Individual;induced pluripotent stem cell derived cardiomyocytes;Injury;innovation;Length;Link;mdx mouse;mechanical force;mechanical load;Mechanical Stress;Mechanics;mechanotransduction;Mission;Modeling;Molecular;mouse model;Muscle;muscular dystrophy mouse model;Mutation;mutation correction;National Heart, Lung, and Blood Institute;novel;novel therapeutics;Organ;Outcome;Patients;Phenotype;Physicians;Physiological;pre-clinical;Pre-Clinical Model;pressure;prevent;Prevention;prime editing;protein expression;Proteins;Public Health;Pump;Research;Research Personnel;Research Project Grants;restoration;Role;Sarcolemma;Scientist;Signal Transduction;Skin;Technology;Testing;therapy development;Tissues;transcriptome sequencing

PROJECT_TITLE: 3D Bioprinted Human Model of Duchenne Muscular Dystrophy (DMD) Cardiomyopathy to Study Disease Progression with Imposed Force and Precise Gene Editing

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative This proposal will advance the field of intravitreal gene therapy for inherited retinal diseases. The aims of this proposal will determine the efficacy of intravitreal compared to subretinal gene therapy, the role of pre-existing circulating antibodies in the host that may mitigate the treatment efficacy, and the degree to which ocular inflammation affects the visual rescue. Together, the aims of this study will advance the understanding of intravitreal gene therapy and its relationship with ocular inflammation and treatment efficacy.

PI_NAMEs: MOSHIRI, ALA  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: adaptive immune response;adenovirus mediated delivery;Affect;Aftercare;Agonist;Alleles;analog;Animals;Antibodies;Area;Atrophic;Biological Assay;Birth;Blindness;Blood;Blood specimen;Breeding;Bulla;California;Capsid;CD8-Positive T-Lymphocytes;Cell Death;Cells;Child;Circulation;Classification;Clinical;clinical phenotype;Clinical Trials;comparative efficacy;Complication;Cone;cytokine;Cytometry;Diffuse;Diffusion;Directed Molecular Evolution;Disease;efficacy evaluation;efficacy testing;Electrophysiology (science);Engineering;Exposure to;Eye;FDA approved;fovea centralis;Gene Combinations;gene induction;gene therapy;Gene Transfer;General Anesthesia;Genes;Genetic;Hand;Homozygote;Immune;Immune system;Immunity;Immunize;Immunohistochemistry;Immunologic Surveillance;Immunosuppression;improved;Inflammation;Inflammatory;Inherited;Injections;Interleukin-10;intravitreal injection;Macaca;Macaca mulatta;macula;Measures;Mediating;Medicine;Mendelian disorder;Modeling;Mutation;Myelogenous;Myeloid Cell Activation;neutralizing antibody;nonhuman primate;novel;Operative Surgical Procedures;Outpatients;Patients;Penetration;Persons;Pharmaceutical Preparations;photoreceptor degeneration;Photoreceptors;Phototransduction;Physiological;prevent;Primates;promoter;Randomized;Reaction;Regimen;Reporting;Research;Retina;Retinal Cone;Retinal Detachment;Retinal Diseases;retinal imaging;Retinal macula;Risk;Role;Route;RPE65 protein;seropositive;Serotyping;Severities;Site;Source;Specialist;Structure of retinal pigment epithelium;subretinal injection;Surgical complication;T cell response;Technology;Testing;Therapeutic;Therapeutic Effect;Therapeutic Studies;therapeutically effective;Time;Tissues;transduction efficiency;Transduction Gene;Transgenes;Treatment Efficacy;Triamcinolone;Uveitis;Variant;vector;Viral;Viral Genes;Viral Vector;Virus;Vision;vision science;Visual;Vitrectomy;Vitreous humor

PROJECT_TITLE: Intravitreal gene therapy for inherited retinal disease

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Depression;Disability Research;Health Services;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: NARRATIVE Despite decades of research on dementia caregiving, prior work has largely focused on a primary caregiver, neglecting the reality that caregiving is provided within complex networks that have the potential to both support, but also complicate, the work of caregivers. The public health impact of this study is through profiling the shared compositional and psychosocial characteristics of caregiver networks in the nationally representative National Health and Aging Trends study and associated National Study of Caregiving to better understand how these complex networks impact the well-being and healthcare utilization of persons living with dementia such that interventions and supports may be targeted toward at-risk caregiver networks. Interventions to support these individuals require a more nuanced understanding of the complexities of caregivers’ networks, while the broader field of caregiving research would benefit from widening its perspective to fully examine these networks.

PI_NAMEs: LEGGETT, AMANDA NOEL (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Accounting;Address;Adult;Affect;Age;Aging;Alzheimer's disease related dementia;Anxiety;anxiety symptoms;Attention;Behavior Therapy;beneficiary;care giving burden;care outcomes;care recipients;caregiver functioning;caregiver stress;Caregivers;caregiving;caregiving research;Caring;Characteristics;Classification;Communities;Complex;Conflict (Psychology);coping;Data;Dementia;dementia care;Dementia caregivers;dementia caregiving;depressive symptoms;Eligibility Determination;Emergency department visit;experience;Family;Family Caregiver;Family dynamics;Family member;Friends;Future;Growth;Health;health care service utilization;Healthcare;Hospitalization;human old age (65+);improved;Individual;Infrastructure;Institutionalization;Intervention;Interview;Link;Long-Term Care;Measures;Medicare;Medicare claim;member;Mental Depression;Mental Health;Meta-Analysis;Modeling;Monitor;Nature;neglect;Network-based;Outcome;Participant;Patients;Pattern;Personal Satisfaction;Persons;Population;Population Heterogeneity;primary caregiver;Process;psychosocial;Psychosocial Assessment and Care;psychosocial stressors;Public Health;Reporting;Research;research and development;Respondent;response;Risk;Role;Sampling;Self Care;Services;sleep quality;statistics;Stress;stressor;Symptoms;systems research;Techniques;theories;therapy development;Time;treatment adherence;trend;Work

PROJECT_TITLE: Profiling Psychosocial Dementia Caregiving Networks: The Impact of Dementia Care Networks on Care Outcomes of Medicare Enrollee Persons Living with Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-L(90)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Data Science;Immunotherapy;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Radiation Oncology

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE Radiotherapy for lung cancer is subject to uncertainties in tissue localizations that lead to increased radiation field sizes and spillover radiation to normal tissues, increasing toxicity and limiting the ability to deliver safe and effective treatments. The goal of this proposal is to develop and validate artificial intelligence (AI) methods for tumor and organ segmentation needed for (1) treatment planning, (2) localization at each treatment fraction on cone-beam computed tomography setup scans, and (3) to quantify the feasibility of reducing treatment margins while effectively and safely delivering lung cancer radiation treatments. If successful, the developed AI software tools would result in more accurate and automated tissue localizations, including at the time of treatment, and would consequently enable more focused, less toxic radiotherapy treatments.

PI_NAMEs: VEERARAGHAVAN, HARINI  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: acute toxicity;Address;Affect;Anatomy;Area;Artificial Intelligence;artificial intelligence method;automated segmentation;automated treatment planning;Cancer Etiology;cancer radiation therapy;Cardiotoxicity;Cessation of life;Characteristics;chemoradiation;chemotherapy;Chest;Clinical;clinically relevant;cohort;Collaborations;Combination immunotherapy;Combined Modality Therapy;Complication;Cone;cone-beam computed tomography;Dangerousness;Data Set;deep learning;Disease;Dose;effective therapy;Ensure;Equipment;Esophagus;feasibility testing;Geometry;Goals;Heart;Image;image guided radiation therapy;imaging study;Immunotherapy;improved;improved outcome;innovation;Lead;Learning;Link;Lung;Lung CAT Scan;Lung Neoplasms;lymph nodes;Magnetic Resonance Imaging;Malignant neoplasm of lung;Manuals;Medal;Mediastinum;Methodology;Methods;Modality;Modeling;Monitor;Morbidity - disease rate;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;Organ;Patient Care;Patients;Positioning Attribute;Primary Neoplasm;Publishing;Pulmonary Inflammation;Radiation;Radiation Dose Unit;Radiation Oncologist;Radiation Oncology;radiation response;Radiation therapy;Radiation Therapy Oncology Group;Recurrence;Research;Risk;Risk-Benefit Assessment;Safety;Scanning;Shapes;simulation;Site;soft tissue;Software Tools;Source;standard care;standard of care;Statistical Models;Survival Rate;System;Systemic Therapy;Technology;Testing;The Cancer Imaging Archive;Time;Tissues;tool;Toxic effect;Training;treatment planning;Treatment-related toxicity;tumor;Uncertainty;Unresectable;Work;Workload

PROJECT_TITLE: Safer lung cancer radiotherapy delivery using novel artificial intelligence methods

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Infectious Diseases;Kidney Disease;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: INDIANAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE We developed a novel urine-based HPV test, with test performances comparing favorably to blood-based HPV testing. Using this test, we obtained preliminary data suggesting first details of the physiological processes underlying blood cell free DNA excretion into urine. This proposal will expand on these findings and explore the potential of our test as a biomarker in oropharyngeal cancer patients undergoing curative intent radiation therapy.

PI_NAMEs: LAUTENSCHLAEGER, TIM  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Anus;Bilateral;Biological Markers;Biological Models;biomarker performance;Blood;Blood Cells;blood fractionation;Blood Volume;Body mass index;Cancer Control;Cancer Patient;cell free DNA;Chronic Kidney Failure;Clinical;cohort;Collection;Data;Detection;detection sensitivity;Diagnosis;Disease;DNA;DNA analysis;DNA sequencing;Eligibility Determination;Excretory function;Filtration;Future;Gender;Gene Frequency;Genitalia;Genome;Goals;Head and neck structure;Home;Hour;HPV analysis;HPV oropharyngeal cancer;HPV positive;HPV screening;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Iatrogenesis;Imaging Techniques;improved;in vivo fluorescence imaging;in vivo Model;Incidence;interest;Kidney;Kidney Diseases;Kinetics;Knowledge;Lead;liquid biopsy;Longitudinal Studies;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;men;Methodology;Modeling;Molecular;Monitor;Mutation;Mutation Detection;Nature;Neck Cancer;Nephrectomy;Newly Diagnosed;Nonmetastatic;novel;Oncogenic;Organ;Outcome;Patients;Performance;performance tests;Persons;Pharmaceutical Preparations;Pharyngeal structure;pharyngeal swab;Physiological Processes;Pilot Projects;Plasma;Radiation Dose Unit;Radiation therapy;Rattus;Recurrence;Research;routine care;Screening for cancer;Sensitivity and Specificity;single molecule;Source;Stream;Swab;targeted treatment;Testing;Time;Tissues;Tube;tumor DNA;Urine;Validation

PROJECT_TITLE: Urine based circulating tumor DNA analysis

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Chronic Pain;Natural Products;Pain Research

ORG_CITY: TUSCALOOSA

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PHR: PROJECT NARRATIVE We propose to develop a cold triggered local anesthesia that allows patients to adjust the degree of pain relief according to their changing needs and conditions. With a single perineural injection or site infiltration, the patient can determine the onset of anesthesia, can trigger anesthesia multiple times to mimic the frequent administration of conventional local anesthetics, and can trigger anesthesia for the duration of post-operative pain state.

PI_NAMEs: ZHAO, CHAO  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Absence of pain sensation;Analgesics;Anatomy;Anesthesia procedures;aqueous;biomaterial compatibility;Body Temperature;Bupivacaine;capsule;Cell Survival;Characteristics;chronic pain;Clinical;clinical application;Cold Therapy;Collection;cost;cytotoxicity;design;Dose;drug action;Drug Carriers;Drug Kinetics;efficacy evaluation;Emulsions;Encapsulated;ethylene glycol;Event;Extravasation;Feasibility Studies;Formulation;Frostbite;Goals;Hour;improved;In Vitro;in vivo;in vivo evaluation;in vivo imaging system;Infiltration;Inflammation;Injectable;Injections;Injury;interest;Libraries;Light;Liposomes;Local anesthesia;Local Anesthetics;Long-Term Effects;Medical;Methods;Microscopic;Microspheres;Modeling;Molecular Weight;Morphology;natural hypothermia;operation;Opioid;Organ;Outcome;Pain management;pain relief;Patients;perineural;Pharmaceutical Preparations;Plasma;poly(lactide);polyglycerol;Polymers;Porosity;Postoperative Pain;Postoperative Period;Preparation;prevent;Procedures;Property;Propylene Glycols;Rattus;Reaction;Research;response;Rupture;Safety;sciatic nerve;screening;Sedimentation process;self assembly;Site;Sodium Fluorescein;Stimulus;Structure;Surgical incisions;System;Temperature;Tetrodotoxin;Time;Tissues;Toxic effect;ultrasound;Water;wound

PROJECT_TITLE: Cold triggered Local Anesthesia for Pain Management

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE People rely on cognitive abilities to function in situations and natural environments experienced in daily life, but research studies assess cognition in “one-shot” in a laboratory or clinical setting, which can yield unreliable results. This study will develop a smartphone app carefully designed to assess cognition with several brief (<3 min) tests per day over the course of a week in people with Down syndrome (DS) at risk for Alzheimer’s disease (AD). If successful, this study will provide new insights into DS-AD and could lead to faster results from clinical trials.

PI_NAMEs: HASSENSTAB, JASON J (contact)

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: Address;Adoption;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease blood test;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;autosomal dominant Alzheimer's disease;autosome;Biological Markers;Blood;Cellular Phone;Chromosome 21;Clinic;Clinical;Clinical Trials;Cognition;Cognitive;cognitive ability;cognitive change;cognitive testing;cohort;cost;critical period;Data;design;Development;Devices;digital;digital assessment;Disease;disease phenotype;Down's Syndrome;effectiveness evaluation;Environment;Evaluation;Exhibits;experience;Fatigue;Focus Groups;genetic variant;Geography;Glial Fibrillary Acidic Protein;Goals;Guidelines;handheld mobile device;Hematological Disease;Human Resources;Impaired cognition;improved;Individual;insight;International;Laboratories;Language;Life;lifetime risk;Light;London;Measurement;Measures;Methodology;Methods;Moods;Nature;neurofilament;Observational Study;older adult;open source;Outcome;Paper;Participant;Performance;Persons;Phase;Phenotype;pilot test;Plasma;Population;Predisposition;prevent;Prevention trial;Process;Psychometrics;rate of change;Readiness;Research;research study;Risk;Role;Series;Serum;Site;Sleep;sleep pattern;smartphone application;smartphone based assessment;Source;Stress;stressor;Symptoms;synuclein;tau-1;Techniques;Technology;technology development;Testing;Therapeutic Intervention;Time;Validation;Work

PROJECT_TITLE: DS-ARC: A Remote Digital Cognitive Assessment for Down Syndrome-Associated Alzheimer's Disease

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cancer;Clinical Research;Contraception/Reproduction;Infertility;Pediatric;Pediatric Cancer;Rare Diseases;Transplantation;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE With increasing awareness of oncofertility, more patients are seeking out fertility preservation options. For pre- pubertal female patients, ovarian tissue cryopreservation is the only available option, but it has been optimized for adult ovaries. This work investigates how the pubertal transition affects the structural, cellular, and molecular microenvironment of the pediatric ovary to improve and expand reproductive options for pediatric cancer survivors.

PI_NAMEs: TSUI, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Adult;Affect;Anatomy;Architecture;Atlases;Autologous;Awareness;Biology;Biopsy;Blood Vessels;Brightfield Microscopy;cancer care;Cancer Patient;cell type;Cells;Childhood;childhood cancer survivor;clinical practice;Coculture Techniques;Collagen;Competence;Complex;Cryopreservation;Cryopreserved Tissue;density;Development;Developmental Process;Environment;Exhibits;experimental study;Female;Fertility;fertility preservation;folliculogenesis;Future;Generations;Goals;Growth;Health;Hematoxylin and Eosin Staining Method;Hormonal;Hormones;Human;Immunofluorescence Immunologic;improved;In Vitro;Knowledge;Lead;Live Birth;Malignant Childhood Neoplasm;Malignant Neoplasms;Meiosis;Microscopy;Molecular;multiple omics;Mus;oncofertility;oocyte maturation;oocyte quality;Oocytes;Organ;Ovarian;Ovarian Follicle;Ovarian Tissue;Ovarian tissue cryopreservation;Ovary;paracrine;Paracrine Communication;Patients;pediatric patients;Population;Premature Menopause;prepuberty;preservation;Primordial Follicle;Proteomics;Puberty;puberty transition;Punch Biopsy;Quality of life;Recording of previous events;recruit;Reporting;reproductive;response;retransplantation;Sagittaria;second harmonic;Siblings;single-cell RNA sequencing;Sirius Red F3B;Specimen;Stains;Steroid biosynthesis;Stromal Cells;Structure;success;System;Technology;Testing;timeline;Tissue Transplantation;Tissues;Vascularization;women patients;Work

PROJECT_TITLE: Understanding the microenvironment of the pediatric ovary across the pubertal transition: implications for fertility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-A(20)L]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: Puerto Rican communities continue to experience catastrophic events. Semilla brings health curricula to children at Boys & Girls Clubs so that they may learn in a space they feel safe. The broader impact of Semilla is a community primed for self-care by enhancing their resilience to current and future events.

PI_NAMEs: CAMPOS-RIVERA, MARIBEL  (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: 12 year old;Academic achievement;adverse childhood events;Age;boys;Buffers;care providers;Career Choice;Caring;Child;Child Support;Childhood;Clinic;Clinical;Communication;Communities;community building;Counseling;Dedications;Development;disadvantaged background;Discipline;Disparity population;Education;Educational Curriculum;Emotional;empowerment;Environment;Event;evidence base;experience;Family;Fellowship Program;Future;Future Generations;girls;Goals;Health;Health education;Health Professional;Health Promotion;Individual;informal learning;Infrastructure;innovation;Joints;Learning;life span;medical specialties;Medicine;Mental Health;Mentors;Mindfulness Training;Modeling;neurobehavioral;Participant;Personal Satisfaction;Plants;Poverty;Prevention approach;Process;programs;Puerto Rican;Puerto Rico;Recovery;recruit;Research Personnel;resilience;response;Risk;Rotation;Science;Science, Technology, Engineering and Mathematics;Scientific Inquiry;Scientist;Self Care;service providers;Social Interaction;Stress;Students;System;Thinness;tool;Toxic effect;Training;Training Programs;Underrepresented Populations;Underrepresented Students;Universities;volunteer;Well in self

PROJECT_TITLE: Semilla - planting the seeds of change for Puerto Rico

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Our proposal will focus on mapping novel regulators of expression using a large internationally-collected series of human brain tissues. This work will leverage two different sites to perform the necessary experiments for further validation of these targets and obtaining the data necessary. Final outputs will include a map of novel regulators of DNA-transcript expression which act on known Alzheimer's disease pathology.

PI_NAMEs: MYERS, AMANDA J (contact)

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: Affect;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's Disease Pathway;Amyloid beta-Protein;Anti-sense RNA;Archives;Binding;Biology;Brain;brain tissue;Cell Culture Techniques;Code;Data;Data Collection;differential expression;Disease;DNA;DNA mapping;experimental study;Genetic Transcription;genome wide association study;genomic variation;Genomics;Genotype;Goals;Human;innovation;interest;International;Investigation;knock-down;Laboratories;Late Effects;Late Onset Alzheimer Disease;Length;Maps;Measures;neurogenomics;novel;Oligonucleotides;Outcome;Output;overexpression;Pathogenicity;Pathologic;Pathway interactions;Peptides;Procedures;Process;Proteins;Proteomics;public database;Quantitative Trait Loci;Regulation;Reproducibility;Resources;Risk;risk variant;RNA;Sampling;scaffold;Sequence Alignment;Series;single molecule;single molecule real time sequencing;Site;Specificity;tau Proteins;Techniques;Technology;Testing;Time;Tissue Banks;Transcript;transcriptome sequencing;transcriptomics;Translations;Untranslated RNA;Validation;Variant;web site;Work

PROJECT_TITLE: THE HUMAN BRAINOME III: EQTL REGULATION BY NATURAL ANTISENSE RNA IN ALZHEIMER S DISEASE

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE Globoid cell leukodystrophy (GLD) is a genetic disease characterized by severe neuroinflammation and demyelination, leading to a very early death in most affected individuals. Excitingly, we have discovered that T-cells are present in diseased brain tissue of GLD and they appear to be engaged with a highly activated glial cell type called microglia which we think underlies the aggressive nature of this disease and its pathology. The goal of this project will be to define how these microglial cells function as professional immune cells to foster the pathological activity of T cells and drive brain injury in this untreatable disease.

PI_NAMEs: SUTTER, PEARL A (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: 5 year old;adaptive immune response;Adaptive Immune System;Affect;Age;Anatomy;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Attention;Axon;behavior test;Behavioral;Brain;Brain Diseases;Brain Injuries;brain tissue;Career Choice;Cd68;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;cell type;Cells;Central Nervous System;central nervous system demyelinating disorder;Cessation of life;Characteristics;Child;Clinical;Cognitive deficits;comparison control;Complex;Cytometry;Data;Dedications;Demyelinations;Development;Disease;Disease Marker;Disease Progression;Environment;Exhibits;Exposure to;Family;Flow Cytometry;Fostering;Future;galactosylceramidase;Genetic Diseases;Gliosis;Globoid cell leukodystrophy;Goals;Histocompatibility;Histocompatibility Antigens Class I;Histologic;Human;Image;Immune;Immunohistochemistry;immunological synapse;Immunologics;improved;Individual;Infant;Inflammation;Innate Immune Response;knock-down;Knockout Mice;Lesion;life span;Lipids;Location;loss of function mutation;Major Histocompatibility Complex;Measures;medical schools;Metals;Microglia;mouse model;Mus;Myelin;myelination;Nature;Nervous System Disorder;Neuroglia;neuroimmunology;neuroinflammation;Neurologic;neuropathology;novel;Onset of illness;Outcome;Paralysed;Pathologic;Pathology;Patients;Pattern;Peptides;Physicians;Play;Population;Psychosine;PTPRC gene;recruit;Research;Role;Sampling;Scientist;Severity of illness;single-cell RNA sequencing;skills;spatial relationship;success;Symptoms;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;Techniques;Testing;Thinking;Time;Tissues;Training;Translating;Transmission Electron Microscopy

PROJECT_TITLE: The role of microglia as antigen presenting cells in Globoid Cell Leukodystrophy


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: LAWRENCE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE The development of new chemotherapeutic approaches for the treatment of infectious disease is, by acclamation, one of the preeminent challenges of modern biomedical science. This Phase II proposal is designed to strengthen and enhance the investments and infrastructure established in Phase I for the Center for Chemical Biology of Infectious Diseases. The CBID Center will continue to address critical gaps and enable researchers at the University of Kansas (KU) and associated institutions to apply these tools to better understand and potentially prevent infectious diseases.

PI_NAMEs: HEFTY, P SCOTT (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Address;Animals;Area;base;Biological;Biological Models;Biology;Centers of Research Excellence;Chemicals;Chemistry;Chemotherapy-Oncologic Procedure;Collaborations;Communicable Diseases;Communities;Core Facility;Coupled;design;Development;drug discovery;Education and Outreach;effective therapy;expectation;experience;Faculty;high throughput screening;Infectious Agent;infectious disease treatment;Infrastructure;innovation;Institution;Intervention;Investments;Kansas;member;Mentors;Mentorship;Microbiology;Modernization;multidisciplinary;novel;Organism;Pathway interactions;Pharmaceutical Chemistry;Pharmacologic Substance;Pharmacology;Phase;Pilot Projects;prevent;Principal Investigator;Process;professor;programs;Proteomics;Public Health;recruit;Research;research facility;Research Personnel;Research Project Grants;Resistance;Resources;Science;Scientist;Series;success;Therapeutic;tool;United States National Institutes of Health;Universities;Validation;Work

PROJECT_TITLE: Chemical Biology of Infectious Disease


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

PROJECT_TERMS: Advisory Committees;Arkansas;Biological Sciences;Biology;career;Chemicals;Communicable Diseases;Dedications;Development;Development Plans;Educational workshop;Ensure;Evaluation;expectation;experience;Faculty;Faculty Recruitment;Financial Activity;formative assessment;Funding;Goals;Grant;Human Resources;Individual;Infrastructure;Institution;Kansas;Leadership;Mentors;Mission;Monitor;Nebraska;Occupational activity of managing finances;Oklahoma;outreach;Peer Review;Phase;Pilot Projects;Process;programs;Recommendation;Reporting;Research;research and development;research facility;Research Personnel;Research Project Grants;Resources;Scientist;Services;Specialist;success;Universities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: BROOKLYN

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: Project Narrative National studies show that the third leading preventable causes of death in the United States are alcohol-related, emphasizing the importance of early detection of vulnerability to develop alcohol use disorder ( AUD ), for prevention and treatment. In this project, we will use rich to predict , as well as identify biological, clinical, and demographic features associated with this disease. We will conduct our analyses in AUD diagnosed and unaffected populations stratified by age, sex, and ancestry, which will help advance our understanding of longitudinal multi-modal data and innovative machine learning methods AUD AUD in groups underrepresented in the literature, especially African Americans and females.

PI_NAMEs: KINREICH, SIVAN  (contact)

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: 18 year old;addiction;Address;Adult;Affect;African American;African American population;African Women;Age;age related;age stratification;aged;Alcohol dependence;alcohol use disorder;Alcohols;American;Attention deficit hyperactivity disorder;base;Biological;Biological Factors;Biological Markers;Brain;Cause of Death;Cessation of life;Characteristics;Classification;Clinical;cohort;Complex;Data;data modalities;deep learning;Demographic Factors;demographics;Development;Diagnosis;Disease;disorder risk;Drug usage;Drunk driving;DSM-IV;Early Diagnosis;Electroencephalography;Electrophysiology (science);Environment;Environmental Risk Factor;European;Evaluation;Family Study;Functional disorder;Gender;Genetic;Genetic Markers;Genetic Models;Genetic study;genetics of alcoholism;Goals;gradient boosting;Health;High-dimensional Modeling;Home;improved;Individual;innovation;interest;Learning;Literature;Machine Learning;machine learning algorithm;machine learning method;Major Depressive Disorder;Measures;men;Methods;Modality;model building;Modeling;multidisciplinary;multimodal data;multimodal modeling;multimodality;neurogenetics;neurophysiology;Participant;peer;Performance;personalized diagnostics;personalized medicine;Phenotype;polygenic risk score;Population;population stratification;Post-Traumatic Stress Disorders;precision medicine;prediction algorithm;predictive modeling;Predisposition;Prevention;Psychiatric Diagnosis;Psychiatry;psychosocial;Public Health;Questionnaires;recruit;Research;Research Personnel;resilience;Risk;risk prediction model;Sampling;secondary analysis;sex;Side;Single Nucleotide Polymorphism;sociodemographics;software development;Subgroup;Surveys;Symptoms;Techniques;Testing;Training;Trees;Underrepresented Populations;United States;Validation;Woman;Work

PROJECT_TITLE: Predicting AUD development, risk and resilience phenotypes through integration of multi-modal COGA data

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Immunization;Infectious Diseases;Prevention;Rare Diseases;Social Determinants of Health;Vaccine Related

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE There are unanswered questions regarding the effectiveness of the recombinant zoster vaccine (RZV) on the development and course of herpes zoster (HZ) and herpes zoster ophthalmicus (HZO). Our proposed project will provide needed information on the changing incidence of HZO and uptake of RZV since implementation, as well as the long-term, real-world effectiveness of the vaccine against HZ and HZO and the effectiveness in under-studied populations with immunocompromising conditions or with a history of HZO. This information could be used to justify support to increase vaccination efforts and to inform recommendations on age-eligibility, the need for additional doses, or to target specific populations to reduce the burden of disease.

PI_NAMEs: ACHARYA, NISHA  (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Academy;Address;Adult;Affect;Age;age group;Age Years;aging population;American;Area;Award;Benefits and Risks;Blindness;burden of illness;California;Clinical;clinical care;Clinical Trials;Cornea;Counseling;COVID-19;COVID-19 pandemic;Data;Data Sources;data warehouse;Databases;Development;Dose;Effectiveness;efficacy trial;Electronic Health Record;Eligibility Determination;Epidemiology;Ethnic Origin;Event;evidence based guidelines;Exclusion;Eye;FDA approved;Future;Gender;General Population;General Practices;Grant;health data;Healthcare;Herpes zoster disease;Herpes Zoster Ophthalmicus;high risk;Immunocompromised Host;Incidence;Income;Individual;insight;insurance claims;Intervention;Knowledge;Licensure;Methods;middle age;Monitor;Morbidity - disease rate;Observational Study;Ophthalmology;patient population;Patients;Philadelphia;Policies;policy recommendation;Population;prevent;Public Health;Publishing;Race;Recombinants;Recommendation;Recording of previous events;Recurrence;Registries;Relative Risks;Research;residence;Risk;Risk Assessment;Safety;Secondary Immunization;social health determinants;Specialist;Subgroup;Surveys;Uncertainty;United States;Universities;uptake;Vaccination;vaccine acceptance;vaccine effectiveness;vaccine efficacy;vaccine safety;Vaccines;Veterans Health Administration;Vision;Weighing patient;Zoster Vaccine

PROJECT_TITLE: The Impact of the Herpes Zoster Vaccine on Herpes Zoster Ophthalmicus

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

PI_NAMEs: ROY, ANURADHA  (contact)

PROJECT_TERMS: Address;Area;assay development;base;Biochemical;Biological;Biological Assay;Biology;Cells;Centers of Research Excellence;Chemicals;Collaborations;Communicable Diseases;Communities;Containment;Core Facility;Dedications;Department of Defense;design;Development;Disease;efficacy evaluation;Ensure;Evaluation;experience;Funding;Funding Opportunities;Goals;hazard;high throughput screening;Individual;Infrastructure;Kansas;Laboratory Study;Libraries;microbial;miniaturize;novel;Organism;Outcome;outreach;outreach program;Pathogenesis;Phase;Pilot Projects;Productivity;Public Health;Research;Research Personnel;Research Project Grants;Resources;response;Running;Scientist;screening;screening services;Services;small molecule;small molecule libraries;Specificity;Therapeutic;Therapeutic Agents;tool;Training;United States National Institutes of Health;Universities;Validation;Virulence;Virulence Factors

PROJECT_TITLE: Infectious Disease Assay Development Core


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

PHR: Project Narrative The goal of the proposed work is to develop a high-fidelity, adaptive electronic interface to the nervous system, capable of interfacing to large populations of neurons at cellular resolution, and use it to probe the function of the parallel visual pathways in behaving animals. The technology will be developed by a team with expertise in neurophysiology, visual behavior, electrical engineering, materials science, surgery, and computation. This platform technology will be used to probe fundamental questions about the function of the early visual pathways, and will be generalizable to a wide variety of scientific and clinical applications.

PI_NAMEs: CHICHILNISKY, EDUARDO  (contact);COGAN, STUART F;HORWITZ, GREGORY D;MELOSH, NICHOLAS A

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Achievement;adaptive optics;Algorithms;Anesthesia procedures;Animals;awake;Behavior;biomaterial compatibility;Blindness;Brain;cell type;Cells;clinical application;Code;density;Devices;Discrimination;Electric Stimulation;Electrical Engineering;Electrodes;Electronics;Encapsulated;experience;experimental study;Future;Goals;Holography;implantable device;implantation;in vivo;Individual;infancy;Influentials;instrument;integrated circuit;Joints;Lateral Geniculate Body;Light;Location;Macaca;magnocellular;materials science;meter;miniaturize;Monkeys;Motion;multi-photon;Nerve Fibers;Nervous System;neural;neural circuit;Neurons;neurophysiology;novel;Operative Surgical Procedures;Optic Nerve;Optics;optogenetics;Oryctolagus cuniculus;parvocellular;Pathway interactions;Penetration;Perception;Population;prevent;Primates;prototype;Resolution;Retina;retina implantation;Retinal Ganglion Cells;retinal prosthesis;retinal stimulation;Role;Shapes;signal processing;Signal Transduction;spatial integration;Specificity;Stimulus;Structure;Surface;Techniques;Technology;technology platform;Testing;Time;Tissues;Viral;Vision;vision science;Visual;Visual Cortex;Visual Pathways;Visual Perception;Work

PROJECT_TITLE: Bi-directional neural interface for probing parallel visual pathways

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


PHR: Project Narrative The regulated exocytosis of neurotransmitters from neurons underlies the function of the nervous system. By elucidating this process, and the mechanisms that underly presynaptic plasticity, we will uncover novel targets and approaches to treat pathophysiological states in which neuronal communication is impaired.

PI_NAMEs: CHAPMAN, EDWIN R (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Acidic Amino Acids;Action Potentials;Acute;addiction;Address;Automobile Driving;Back;Binding;Binding Sites;Biological Assay;Brain;Brain region;C2 Domain;Calorimetry;cell type;Communication;complement C2a;complement C2b;Confusion;Corpus striatum structure;Cryoelectron Microscopy;Data;Dense Core Vesicle;Docking;Dopamine;Dorsal;Dose;Electron Microscopy;Exocytosis;experimental study;Freezing;gain of function;Gene Family;Goals;Head;Hippocampus;Hormones;Image;Impairment;Individual;insight;instrument;Ions;Ligands;Measurement;Mediating;member;millisecond;Modeling;Morphologic artifacts;mutant;Mutation;Nerve;Nervous System Physiology;Neuromodulator;Neurons;neurotransmitter release;Neurotransmitters;novel;overexpression;Pathology;Patients;pharmacologic;Physiologic pulse;Play;Preparation;presynaptic;Process;Property;Protein Isoforms;reconstitution;Reporting;Research;Resistance;response;Role;Schizophrenia;sensor;Side;Slice;striosome;Structure;Substance P;synaptic depression;synaptic function;Synaptic plasticity;Synaptic Vesicles;synaptotagmin;synaptotagmin I;Testing;Time;Titrations;tomography;transmission process;vesicular release;Work

PROJECT_TITLE: Synaptotagmin C2B Domain as a Ca2+ Sensing Module

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-G(06)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Influenza;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Pneumonia and Influenza;Precision Medicine;Prevention;Vaccine Related

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Bringing together teams from three complementary disciplines, vaccinology, immunology, and systems biology, we propose to use novel methods for machine learning to examine multiple immune parameters in older healthy weight and obese individuals who are weak and robust responders to advanced-generation influenza vaccine. Analyses include single cell transcriptional and chromatin (multi-ome) profiling of the innate and adaptive compartments, cytokine profiling, multi-dimensional antibody profiling, and enumeration of HA-specific memory B and plasma cell precursors. We will combine transcriptomic, epigenetic and cytokine datasets to uncover both predictive correlates and causal latent factors of variable immunogenicity and compare them between healthy weight and obese individuals.

PI_NAMEs: ALCORN, JOHN F (contact);DAS, JISHNU ;SINGH, HARINDER ;ZIMMERMAN, RICHARD K

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Address;Adult;Affect;Age;age effect;aged;Antibodies;Antibody Response;B-Lymphocytes;Blood specimen;Body mass index;Cell Compartmentation;Cells;Cellular Immunity;Chromatin;cohort;Computer Analysis;Coupled;cytokine;Data Set;Development;Dimensions;Discipline;Effectiveness;Epigenetic Process;exceptional responders;experimental analysis;explainable machine learning;Flow Cytometry;frailty;gene regulatory network;Generations;Genetic;Genetic Transcription;genomic profiling;Genomics;healthy weight;high dimensionality;Immune;Immune response;Immunity;immunogenicity;Immunology;Impairment;Individual;Infection;Inflammation Mediators;Influenza;Influenza prevention;Influenza vaccination;influenza virus vaccine;insight;Knowledge;Machine Learning;machine learning framework;machine learning method;machine learning prediction;Measures;Memory;Memory B-Lymphocyte;middle age;Molecular;molecular marker;Molecular Profiling;multiple omics;novel;obese person;Obesity;older adult;Older Population;Outcome;Participant;Pathway interactions;Pattern;Peripheral Blood Mononuclear Cell;Phenotype;Plasma Cells;Plasmablast;programs;Proteins;Race;response;screening;seasonal influenza;sex;Structure of germinal center of lymph node;System;Systems Biology;Testing;transcriptomics;Vaccination;Vaccine Design;vaccine formulation;vaccine immunogenicity;vaccine response;Vaccines;vaccinology;Variant;Vitamin D;Vulnerable Populations

PROJECT_TITLE: Uncovering latent factors underlying weak and robust responses to influenza vaccine in healthy and obese older adults


PI_NAMEs: JOHNSON, DAVID K (contact)

PROJECT_TERMS: base;biological research;Biology;Centers of Research Excellence;Chemicals;Communicable Diseases;Communities;Complement;Computational Biology;Computer Assisted;Computer Hardware;computerized tools;computing resources;Core Facility;Decision Making;design;Development;Docking;drug discovery;Environment;experience;Facility Accesses;Faculty;high throughput analysis;high throughput screening;improved;Infectious Diseases Research;Informatics;Infrastructure;inhibitor;innovation;insight;interest;Investments;Kansas;lead optimization;Leadership;Ligands;macromolecule;Mission;Modeling;Modernization;molecular modeling;novel strategies;outreach;pathogen;Pathogenicity;Peptides;Phase;Play;Productivity;programs;Protein Engineering;protein function;Proteins;Research;Research Personnel;Research Support;Resources;Role;Scientist;screening;Services;Site;Structure;Techniques;tool;virtual screening

PROJECT_TITLE: Computational Chemical Biology Core


PI_NAMEs: PERERA, CHAMANI  (contact)

PROJECT_TERMS: base;Benchmarking;Biological;Biology;Biomedical Research;Biotin;Centers of Research Excellence;Chemicals;Client;Collaborations;Collection;combat;Communicable Diseases;Communities;Custom;design;Development;drug discovery;Evaluation;experience;fabrication;fluorophore;Fostering;Foundations;Goals;Health;In Vitro;in vivo;innovation;interest;Isotopes;Kansas;Lead;Mission;Molecular Probes;outreach;Pathway interactions;Peptide Synthesis;Peptides;Pharmaceutical Chemistry;pharmacologic;Phase;Pilot Projects;preclinical study;programs;Property;Proteins;Research;Research Personnel;Research Project Grants;screening;Services;small molecule;Structure-Activity Relationship;success;Synthesis Chemistry;Therapeutic;tool

PROJECT_TITLE: Synthetic Chemical Biology Core


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF THE INCARNATE WORD

ORG_STATE: TX

PHR: Project Narrative Relevance: Alzheimer’s disease (AD) covers 70% of the dementia spectrum. It is the 6th killer of people 65 and older in the US and yet the five indicated drugs lack clinical efficacy in slowing disease progression or modifying the disease. Since the disease is multi-factorial, this project will generate single molecules (via structural modifications of Tubastatin A) endowed with combo-activity via sigma receptor signaling and histone deacetylase-6 or HDAC6 isozyme (two promising targets for countering neurodegeneration and declines in cognition), in an effort aimed at probing novel druggable mechanisms towards the ultimate development of disease modifying pharmacotherapeutics for AD.

PI_NAMEs: SIKAZWE, DONALD M (contact)

PROJECT_TERMS: Affinity;Alzheimer's Disease;Amyloid beta-Protein;Analytical Chemistry;Animal Disease Models;antagonist;Applications Grants;Binding;Biological Assay;Cause of Death;Cessation of life;Chemicals;cholinergic;Cholinesterase Inhibitors;Cholinesterases;Clinical;clinical efficacy;Clinical Trials;Cognition;Cognitive deficits;cognitive function;Complex;Data;Dementia;design;Development;Disease;Disease Progression;Drug Design;drug development;Endowment;Enzyme Inhibition;Etiology;Evaluation;Exhibits;Failure;Follow-Up Studies;Future;Glutamates;Goals;HDAC6 gene;Health;Health Care Costs;Histone Deacetylase Inhibitor;human old age (65+);Hydroxamic Acids;Impaired cognition;Impairment;improved;In Vitro;Individual;inhibitor;innovation;Isoenzymes;Lead;Ligands;meetings;Methods;Modification;multimodality;N-Methyl-D-Aspartate Receptors;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;novel;novel therapeutics;Outcome;palliative;Pathogenicity;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;poor health outcome;radioligand;receptor;receptor binding;Receptor Signaling;repaired;Reporting;Research;screening;Second Messenger Systems;Series;sigma receptors;sigma-2 receptor;Signal Transduction;single molecule;small molecule;statistics;Structure-Activity Relationship;Synthesis Chemistry;tau Proteins;Techniques;Testing;Toxic effect

PROJECT_TITLE: Single molecules with multi-mechanistic modes of action as probative anti-Alzheimer’s agents


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_DEPT: PHARMACOLOGY

PHR: Narrative and Public Health Relevance Heart failure is a leading cause of mortality in the United States. Cardiac b1 adrenergic signaling is a critical regulator of cardiac function. We aim to characterize a novel pool of intracellular b1 adrenergic receptor that is essential for cardiac function. We aim to find how to target this pool of receptors in enhancing cardiac function in heart failure.

PI_NAMEs: NAVEDO, MANUEL F;XIANG, YANG K (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: access restrictions;Acute;Adrenergic Agents;Adrenergic Receptor;Affect;aorta constriction;ATP2A2;Attenuated;Biosensor;Calcium;Cardiac;Catecholamines;Cell membrane;Cell surface;Cells;Chronic;Clinical;Complex;Coupling;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Depressed mood;desensitization;EFRAC;Endocytosis;Enzymes;Fluorescence Resonance Energy Transfer;Genetic;Heart;Heart failure;heart function;Human;Impairment;In Vitro;in vivo;Infusion procedures;monoamine;Monoamine Oxidase A;mortality;mouse model;Mus;Muscle Cells;novel;Organic Cation Transporter;overexpression;pharmacologic;Pharmacotherapy;phospholamban;Phosphorylation;Physiological;public health relevance;receptor;Receptor Activation;Receptor Signaling;Regulation;Reporting;Resistance;response;Sarcoplasmic Reticulum;sarcoplasmic reticulum calcium ATPase;Scheme;Signal Transduction;Stress;Testing;therapeutic target;United States

PROJECT_TITLE: Regulation of a cardiac b1AR/SERCA2 complex in heart failure