ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Dysfunction of the blood-nerve barrier (BNB) has been implicated in many peripheral nerve pathologies, including diabetic peripheral neuropathy, but has remained vastly understudied especially in comparison to the blood-brain barrier (BBB). In this proposal, we will investigate the transcriptomic differences between the blood- nerve barrier (BNB) and the blood-brain barrier (BBB) through single cell RNA sequencing in order to better understand the fundamental biology of the BNB. We will also use scRNA-sequencing to investigate the transcriptomic changes to BNB in a mouse model of diabetes, allowing for analysis of the progression of BNB changes leading to its dysfunction during disease.

PI_NAMEs: DANEMAN, RICHARD  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Adult;Age;Astrocytes;Biology;Biopsy;Blood;Blood - brain barrier anatomy;Blood Cells;Blood Vessels;Blood-Nerve Barrier;Body System;Cell Adhesion Molecules;Cell Communication;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Characteristics;clinically relevant;Data;Data Analyses;debilitating pain;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;differential expression;Disease;Endothelial Cells;Environment;Esthesia;experimental study;Extracellular Matrix;Functional disorder;Gene Expression;Genes;Goals;Health;Immune;Immunomodulators;inflammatory marker;inhibitor;Ions;Ligands;Light;Limb structure;Modeling;Molecular;Molecular Analysis;mouse model;Movement;Multiple Sclerosis;Mus;Nerve;Nerve Tissue;Nervous System;neural;Neuroglia;neuronal cell body;Neurons;Neuropathy;neuroregulation;novel;novel therapeutic intervention;novel therapeutics;Optic Nerve;Organ;pathogen;Pathology;Patients;Pericytes;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Permeability;Physiological;Physiology;Population;Process;Property;Proteins;receptor;Regulation;Research Personnel;Resources;Schwann Cells;sciatic nerve;Signal Pathway;single-cell RNA sequencing;solute;Symptoms;Technology;therapeutic target;Tight Junctions;Time;Tissues;Toxin;transcriptome;transcriptome sequencing;transcriptomics;transcytosis;Type 2 diabetic;white matter

PROJECT_TITLE: Molecular analysis of the blood-nerve barrier in health and diabetes

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PI_NAMEs: SHEN, SHAUNNA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS Vaccines;Animals;Biological Assay;Collaborations;Contractor;Contracts;Detection;Ensure;Epidemic;HIV;HIV vaccine;Immune response;Immunization;Immunize;immunogenicity;Immunologic Tests;Immunologics;Immunology;improved;Infection;Infection prevention;Laboratories;Mission;Modeling;National Institute of Allergy and Infectious Disease;neutralizing antibody;nonhuman primate;pre-clinical;Prevention strategy;Reproducibility;Research Personnel;Research Support;simian human immunodeficiency virus;Site;SIV;SIV Vaccines;Standardization;Testing;therapy development;United States National Institutes of Health;vaccine development;vaccine evaluation;Vaccine Research;vaccine strategy;Viral Physiology;virology;Virus;Virus Replication

PROJECT_TITLE: Nonhuman Primate Core Humoral Immunology Laboratory for AIDS Vaccine Research and Development


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: SAN JOSE

ORG_NAME: CCS ASSOCIATES, INC.

ORG_STATE: CA

PHR: This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to understand the basis of pain and enhance clinical pain management.

PI_NAMEs: MANDEL, DIRK  (contact)

PROJECT_TERMS: Affect;Amendment;Area;clinical pain;Clinical Protocols;Clinical Research;Discipline;drug development;drug discovery;Ensure;experience;Familiarity;Guidelines;Helping to End Addiction Long-term;Industry;Investigational New Drug Application;Leadership;Medical;Neurosciences;Pain;Pain management;Pamphlets;Pharmaceutical Preparations;Preparation;Process;Program Development;Quality Control;Recommendation;Research Personnel;Role;Services;Speed;timeline;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: MEDICAL WRITING CONSULTING SERVICES


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The presynaptic voltage-gated calcium channel CaV2.1 drives synaptic transmission, however we lack fundamental understanding of the mechanisms that direct CaV2.1s to the presynaptic terminal. The CaV2.1 C- terminus has emerged as a major regulator of presynaptic CaV2.1 trafficking. This proposal aims to characterize the trafficking functions of key sequences within the CaV2.1 C-terminus, providing insight into the cellular mechanisms of synapse formation and maintenance and the treatment of neuropathies that stem from failures in calcium channel trafficking.

PI_NAMEs: CHIN, MORVEN  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Address;Affect;Axon;Axonal Transport;Biology;C-terminal;Calcium;Calcium Channel;Cell Line;Cell membrane;Cells;Chimera organism;Cytoplasm;Data;Dendrites;Destinations;EF Hand Motifs;Electrophysiology (science);Exhibits;experimental study;Face;Failure;Goals;Golgi Apparatus;Healthcare;Hippocampus;Image;Individual;insight;Maintenance;Mediating;Microscopy;millimeter;Mus;mutant;Mutation;neuronal cell body;Neurons;Neuropathy;neurotransmitter release;novel;P-Q type voltage-dependent calcium channel;Pathway interactions;Phase;Positioning Attribute;postsynaptic;presynaptic;presynaptic neurons;Presynaptic Terminals;Protein Isoforms;Proteins;Role;Route;scaffold;Site;Sorting;Source;stem;superresolution microscopy;Synaptic Membranes;Synaptic Transmission;Synaptic Vesicles;synaptogenesis;Testing;trafficking;Transfection;Travel;Vesicle;Visualization;voltage;Whole-Cell Recordings

PROJECT_TITLE: Dissecting the Forward Trafficking of Presynaptic Voltage Gated Calcium Channels


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Precision Medicine

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NY

PHR: No Text

PI_NAMEs: COHN, ELIZABETH GROSS (contact)

PROGRAM_OFFICER_NAME: MARTINEZ, ERICA

PROJECT_TERMS: All of Us Research Program;Equity;Investigation;Text;Translations

PROJECT_TITLE: The Interdisciplinary Guided Network for Investigation, Translation and Evidence (IGNITE) for All of Us Research Program


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PI_NAMEs: DENNY, THOMAS  (contact)

PROJECT_TERMS: Development;influenza virus vaccine;innovation;manufacture;Safety;Toxic effect;Toxicology;universal influenza vaccine;vaccine platform;Vaccines

PROJECT_TITLE: Collaborative Influenza Vaccine Innovation Centers (CIVICs): Component B: Vaccine Manufacturing and Toxicology Core


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences;Physical Activity;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE – PUBLIC HEALTH RELEVANCE A key goal of “Healthy People 2030” is to improve health of adults through aerobic physical activity, and soccer, which is the most popular sport on earth, is an aerobic outlet for more than 25 million Americans of all ages that provides significant benefits for brain health. However, we and others have shown that repetitive subconcussive head impacts from soccer heading are associated with signs of subclinical brain injury among young adults, which impact function and may pose risk for neurodegeneration. Delineating the risk vs. benefit to cognitive performance from soccer, based upon a robust scientific foundation, can transform perception of risk by stakeholders and facilitate guidanceon soccer participation for young adult players with decades of future needs, and potential to impact their wellbeing, healthcare footprint and productivity for decades.

PI_NAMEs: LIPTON, MICHAEL LAWRENCE (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Adult;Adverse effects;Aerobic;Age;Alleles;American;Anisotropy;apolipoprotein E-4;Attenuated;attenuation;Benefits and Risks;Brain;Brain Concussion;brain health;Brain Injuries;Brain-Derived Neurotrophic Factor;central nervous system injury;Cognitive;cognitive change;cognitive enhancement;cognitive function;cognitive performance;cognitive testing;combat;Diffusion;Diffusion Magnetic Resonance Imaging;Enrollment;Equilibrium;Exhibits;Exposure to;Follow-Up Studies;Foundations;Future;genetic variant;Goals;Harm Reduction;head impact;Health;Healthcare;Impairment;improved;indexing;injury and repair;insight;Joints;Knowledge;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Mediation;Mediator;Morbidity - disease rate;Myelin;Myelin Water Imaging;myelination;Nerve Degeneration;neuroimaging;Outcome;Participant;Personal Satisfaction;Persons;Physical activity;Planet Earth;Play;Productivity;protective effect;public health relevance;Reporting;Risk;risk perception;Role;Sampling;Soccer;Sports;Structure;subconcussion;Testing;Time;VO2max;Water;white matter;white matter change;Work;young adult

PROJECT_TITLE: Heading and Soccer: understanding cognitive risks, benefits, and the potentialmediating role of white matter

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Neurosciences;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke

ORG_CITY: SAN ANTONIO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative Stroke can cause permanent learning, memory, and motor deficits. Adult neural stem cells have the capacity to home to the brain injury and are thought to be an important part of the repair process after stroke. This proposal aims to gain a better understanding of processes that influence adult neural stem cells following stroke and to identify future strategies to increase brain repair following stroke.

PI_NAMEs: SAYRE, NAOMI LEDENE (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Ablation;Acute;Address;Adult;Affect;Animals;Automobile Driving;Brain;Brain Injuries;brain repair;burden of illness;C-terminal;Cell Differentiation process;Cell membrane;cell motility;Cell Nucleus;Cells;chemokine receptor;chromatin immunoprecipitation;Clinical;Cues;Data;Defect;deprivation;Disease;experience;extracellular;Finding by Cause;Functional impairment;Future;Genetic Transcription;Glucose;healing;Home;Impairment;improved;In Vitro;in vivo;insight;Intervention;Ischemia;ischemic lesion;Ischemic Stroke;Knock-out;Knockout Mice;Laboratories;LDL-Receptor Related Protein 1;Learning;Lesion;Ligands;Lipoprotein Receptor;Long term disability;Malignant Neoplasms;Measures;Mediating;Membrane;Membrane Proteins;Memory impairment;Messenger RNA;Methods;Middle Cerebral Artery Occlusion;migration;Modeling;motor deficit;motor impairment;motor recovery;mouse model;Mus;nerve stem cell;nestin protein;neuroblast;Neuroglia;Neurologic;neuroprotection;new therapeutic target;news;novel;Oxygen;Pathway interactions;Patients;post stroke;Process;Production;Proliferating;Protein C;protein expression;Proteins;receptor;receptor binding;Recovery;red fluorescent protein;Regulation;repaired;Research;response;Role;self-renewal;Signal Transduction;Signaling Protein;Site;stem cell biology;stem cell function;stem cell migration;stem cell proliferation;stem cell survival;Stem cell transplant;Stroke;stroke outcome;stroke recovery;subventricular zone;Surgical Models;Survivors;Tertiary Protein Structure;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Time;Tissues;trafficking;transcription factor;Transcriptional Regulation;United States;Up-Regulation;virtual

PROJECT_TITLE: LRP1 as a novel regulator of CXCR4 in adult neural stem cells and post-stroke response

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: Los Angeles

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Pontocerebellar Hypoplasia Type 1b (PCH1b) is a devastating inherited neurological disorder that preferentially affects specific regions of the brain, the pons and the cerebellum, causing children born with this condition to have dramatically reduced lifespans. The mutations that cause PCH1b occur in a gene that encodes a critical component of a molecular machine that is important for the regulation of gene expression. The proposed studies exploit the fruit fly (Drosophila) as a model system to provide insight into molecular mechanisms underpinning PCH1b.

PI_NAMEs: MORTON, DERRICK  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Affect;Alleles;Amino Acid Substitution;Amino Acids;Atrophic;Attention;autosome;Behavior;behavioral phenotyping;Biochemical;Biological;Biological Models;Biology;Biophysics;Brain;brain morphology;Brain region;Breathing;Catalytic Domain;CCRL2 gene;Cell model;Cell Nucleus;Cells;Cerebellum;Child;Childhood;Clinical;Complex;CRISPR/Cas technology;Cytoplasm;Data;Defect;Development;Developmental Delay Disorders;Disease;dosage;Drosophila genus;Enhancers;Etiology;exosome;Fishes;fly;gene editing technology;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;Genetic Screening;Genotype;Goals;Heterogeneity;Homeostasis;Homologous Gene;Human;Impairment;In Situ;in vivo;in vivo Model;Individual;Inherited;insight;Life;life span;Link;Mass Spectrum Analysis;Methods;Microcephaly;Missense Mutation;Modeling;Molecular;Molecular Machines;Motor;motor behavior;motor learning;Movement;Muscular Atrophy;mutant;Mutation;Nervous System;Nervous System Disorder;neurodevelopment;Neurodevelopmental Disorder;Neuronal Dysfunction;Neurons;novel;palliative;Pancreatic ribonuclease;Pathology;Phenotype;Play;Pontine structure;Pontocerebellar hypoplasia;Post-Transcriptional Regulation;Post-Transcriptional RNA Processing;Reporting;Ribonucleases;RNA;RNA Decay;RNA Processing;Role;sensory system;Sequence Deletion;Series;Severities;single-cell RNA sequencing;Spinal Cord;System;Technology;Testing;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Variant;Work

PROJECT_TITLE: Investigating RNA dysregulation in Neurological Disease through study of Pontocerebellar Hypoplasia Type 1b


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: This project studies how cells that die, in particular those neurons dying of necrosis after injury, are recognized by engulfing cells, an event that leads to the internalization and digestion of these dying neurons. During stroke, cancer, and other traumatic situations, many cells undergo necrosis and apoptosis after injury; the swift removal of these cells prevents tissue injury, inflammatory responses, and auto-immune responses, clears the wounded area, and promotes tissue repair. Understanding the mechanisms controlling the recognition of necrotic neurons will have important therapeutic implications in fighting chronic inflammatory and auto-immune diseases, and in treating neurodegenerative diseases and stroke.

PI_NAMEs: ZHOU, ZHENG  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: age related deterioration;Alleles;Alzheimer's Disease;Animals;Apoptosis;Apoptotic;ATP-Binding Cassette Transporters;Autoimmune Diseases;Autoimmune Responses;Axon;axon injury;Biochemical;Caenorhabditis elegans;Cell Death;Cell Death Process;Cell membrane;Cell Separation;cell suicide;Cells;chronic inflammatory disease;Cytoplasm;Development;Digestion;Disease;dominant genetic mutation;Eating;Endoplasmic Reticulum;Endosomes;epithelial Na+ channel;Event;Evolution;Excision;Family;fighting;Gene Mutation;gene product;Genes;genetic analysis;Genetic Epistasis;Genetic Screening;Goals;Health;Homeostasis;Homologous Gene;Human;in vitro Assay;Induced Mutation;Inflammatory Response;Injury;Ion Channel Protein;Learning;Life;Malignant Neoplasms;Mediating;member;Microglia;model organism;Molecular;Morphology;mutant;Natural regeneration;Necrosis;Necrosis Induction;Nematoda;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neurons;novel;Outcome;Pathologic;Pathway interactions;Phagocytes;Phagocytosis;Phenotype;Phosphatidylserines;phospholipid scramblase;Phospholipids;Physiological;Prealbumin;prevent;Process;Protein Family;Proteins;receptor;Recovery;Recycling;repaired;response;Role;Side;Signal Transduction;Stress;Stroke;stroke recovery;Surface;Synapses;tat Protein;Testing;Therapeutic;tissue injury;tissue repair;Touch sensation;Translating;Wounded area

PROJECT_TITLE: How are necrotic neurons recognized by their phagocytes

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: HYATTSVILLE

ORG_NAME: MEDSTAR HEALTH RESEARCH INSTITUTE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Domestic violence incidents are highly under-identified which requires healthcare providers to be able to detect potential domestic violence-related visits by the structure of traumatic injuries, health problems (e.g., migraines, cardiovascular disease, abdominal pain), and verbal cues. We propose to analyze electronic health records associated to domestic violence related visits to emergency department, use data science techniques to identify injury and health problem patterns that frequently co-occur and apply deep learning-based natural language processing methods to learn verbal cues embedded in patient and provider narratives. Moreover, we will conduct semi-structured interviews with emergency department health providers to investigate the barriers to screen for domestic violence among women during patient-provider encounter. 1

PI_NAMEs: TABAIE, AZADE  (contact)

PROGRAM_OFFICER_NAME: BLACHMAN, DARA

PROJECT_TERMS: Abdominal Pain;Accident and Emergency department;Acute;advanced analytics;Anxiety;Battered Women;Behavior;Cardiovascular Diseases;care seeking;Caring;Characteristics;Chronic;chronic pain;Clinical;Code;Collaborations;COVID-19 pandemic;Critical Care;Cues;Data;Data Analyses;Data Collection;data mining;Data Reporting;Data Science;Data Scientist;Decision Support Systems;deep learning;Dependence;Diagnosis;Disproportionately impacts women;Domestic Violence;Economics;Electronic Health Record;Emergency Care;Emergency department visit;Emergency Medicine;Emergency Situation;Emotional;emotional abuse;Environment;experience;Female;Fright;Future;gender-based violence;Goals;Government;Grant;gun violence;Health;Health Personnel;health training;healthcare burden;Healthcare Systems;high risk;Hospitals;Hotlines;ICD-9;improved;Individual;Informatics;Injury;insight;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);internet violence;Interpersonal Violence;Intervention;Interview;intimate partner violence;Investigation;Learning;Life;Maps;Marketing;Medical;men;Methods;mid-career faculty;Migraine;Mining;Modeling;Morbidity - disease rate;mortality;Movement;Natural Language Processing;Nature;Outcome Study;Output;pandemic disease;Patient Self-Report;Patients;Pattern;perpetrators;physical abuse;Play;prevent;Process;programs;Provider;psychologic;Public Health;Reporting;Research;Risk;Role;Scientist;screening;Screening procedure;Services;Sexual abuse;sexual exploitation;sexual violence;Shame;social;Spirituality;Standardization;stay-at-home order;Structure;Survivors;Symptoms;Techniques;Trauma;Traumatic injury;United States;Universities;verbal;Verbal Learning;Violence;violence against women;Violent injury;Virus;Visit;Washington;Woman;Work

PROJECT_TITLE: Barriers to Screen for Domestic Violence among Women in Emergency Department

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative Reproduction is a tightly regulated function of an organism that is crucial to the perpetuation of a species. The regulation of pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), plays an essential role in this reproductive process. The objective of this proposal is to delineate the precisely coordinated pathways by which hormonal signals direct appropriate LH and FSH gene expression, protein synthesis, and secretion to promote sexual maturation and control normal reproductive function.

PI_NAMEs: KAISER, URSULA B. (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Amenorrhea;Animal Model;Award;Cell model;Cell surface;Complex;Contraceptive methods;Couples;Coupling;Delayed Puberty;Endocrine Physiology;experience;Family;Family member;Female;Fertility;Follicle Stimulating Hormone;Frequencies;G(q) Alpha;G-Protein Signaling Pathway;Gametogenesis;Gene Deletion;Gene Expression;Gene Modified;GNRH1 gene;Goals;gonad function;Gonadal Steroid Hormones;Gonadotropin Hormone Releasing Hormone;Gonadotropins;GTP-Binding Protein alpha Subunits, Gs;hormonal signals;Hormones;human model;Hypothalamic structure;In Vitro;in vivo;Infertility;infertility treatment;insight;Luteinizing Hormone;male;Mediating;model building;Molecular;Molecular and Cellular Biology;mouse genetics;mouse model;Mus;Neuropeptides;NR4A2 gene;Nuclear Family;Nuclear Hormone Receptors;Nuclear Receptors;Organism;Ovarian;Pathway interactions;Pattern;peptide hormone;Periodicity;Physiologic pulse;Physiological;Physiology;Pituitary Gonadotropins;Play;Polycystic Ovary Syndrome;Positioning Attribute;Precocious Puberty;Protein Biosynthesis;receptor;Regulation;Regulatory Element;Reproduction;reproductive;reproductive function;Reproductive Medicine;Reproductive Physiology;Reproductive Process;reproductive system disorder;Research;response;Role;Sexual Maturation;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Steroid biosynthesis;Syndrome;System;Testing;therapeutic target;transcription factor;Translating

PROJECT_TITLE: Reproductive physiology of gonadotropin synthesis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Pediatric;Social Determinants of Health

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: PROJECT NARRATIVE The goal of the proposed research is to investigate how clinical genomic sequencing impacts families of pediatric patients. This research will develop an empirically informed framework of normative values important to families of pediatric patients, including ethical, legal, and social implications (ELSI), which will then be used to elicit preferences for features of sequencing from a nationally representative sample of parents in the US. The results of this work will lead to a measure of family utility that integrates ELSI and can be used in a decision analytic model to assess the impact of genomic sequencing and the importance of including family- level ELSI considerations in such analyses.

PI_NAMEs: SMITH, HADLEY STEVENS (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, DAVE J

PROJECT_TERMS: Affect;American;Area;Award;Biological;career;career development;Child;Childhood;Clinic;Clinical;clinical care;clinical implementation;clinically relevant;college;Communication;comparative effectiveness;comparative effectiveness analysis;Country;Data;Decision Making;Development Plans;diagnostic tool;economic evaluation;Effectiveness;effectiveness evaluation;Ethical Theory;ethical, legal, and social implication;Ethics;Evaluation;evidence base;exome sequencing;experimental study;Family;Family member;Family Study;follow-up;Genetic;Genetic Diseases;Genetic Screening;Genomic medicine;Genomics;Goals;Guidelines;Health;health economics;Health Policy;improved;Individual;individual patient;innovation;Insurance Coverage;Interview;Measurement;Measures;Medical center;Medical Ethics;Medical Genetics;medical schools;Medicine;Mentors;Mentorship;Methodology;Methods;Modeling;models and simulation;Nature;Outcome Assessment;Outcome Measure;Outcomes Research;Parents;Pathway interactions;Patient Preferences;Patients;pediatric patients;Pediatrics;Phase;Physicians;Policies;Policy Analysis;population health;preference;Process;professor;programs;Qualitative Research;Recommendation;Research;research clinical testing;Research Methodology;Research Personnel;Research Project Grants;Resources;Sampling;Science;screening guidelines;skills;Structure;tenure track;Testing;Training;uptake;Weight;Work

PROJECT_TITLE: An ELSI-Integrated Evaluation of the Family-Level Utility of Pediatric Genomic Sequencing


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Liver Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Transplantation

ORG_CITY: INDIANAPOLIS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The LT-CARE (Liver Transplant-Community Access for Referral Equity) Pilot Study aims to address disparities in liver transplantation (LT) access for patients with decompensated cirrhosis by developing a multicomponent referral toolkit. Through engaging a diverse group of community partners, including providers and patients/caregivers, LT-CARE seeks to improve equity in LT referral by addressing barriers at the health system, provider, and patient levels. By implementing and pilot testing LT-CARE in community gastroenterology (GI) practices across urban and rural settings, the project aims to evaluate its feasibility, acceptability, and effectiveness in enhancing equitable LT access.

PI_NAMEs: NEPHEW, LAUREN  (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: access disparities;Address;Alcoholic Liver Diseases;Ascites;Black Populations;Caregivers;Caring;Cessation of life;Chronic Disease;chronic liver disease;Cirrhosis;Clinical Research;cognitive interview;Communities;community based research;community engaged research;community partners;County;Disparity;Effectiveness;Engineering;Epidemiologic Methods;Equity;ethnic minority;Ethnic Origin;evidence base;Evidence based practice;experience;Gastroenterology;Goals;Health;health care settings;Health Disparities Research;health disparity;Health system;Healthcare Systems;Hemodialysis;Hemorrhage;Hepatic Encephalopathy;Hispanic;Hospitals;implementation outcomes;implementation science;improved;Indiana;Individual;Intervention;iterative design;Knowledge;Latina;Latino;Latinx;Life;literacy;liver transplantation;Location;Medical;Medicine;Metabolic dysfunction;Pathway interactions;patient population;Patients;Pattern;Persons;Pilot Projects;pilot test;Policies;Population;post implementation;Primary carcinoma of the liver cells;Process;Protocols documentation;prototype;Provider;racial minority;Research Methodology;Resources;Rural;rural counties;rural setting;safety net;Self-Help Devices;Site;social;Statistical Methods;Steatohepatitis;Surveys;Time;transplant centers;Transplantation;Uninsured;United States National Academy of Sciences;Universities;urban setting;usability;Viral hepatitis;Waiting Lists

PROJECT_TITLE: Liver Transplant-Community Access for Referral Equity (LT-CARE) Pilot Study


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Precision Medicine;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Although progress has been made in oral cavity squamous cell carcinoma (OCSCC), the mainstays of treatment continue to be surgery, radiation, and chemotherapy, with metastasis and poor responses to treatment representing the most common reasons patients die from this disease. The study will use advanced imaging and sequencing approaches to determine how architectural features of tumors and other cells in the tumor ecosystem influence a state called hybrid epithelial/mesenchymal (HEM), which we have shown to adversely affect patient outcomes. This ReWARDS R01 proposal will integrate our overarching research goals (predicting response to treatments such as immunotherapy) with our DEIA goals of incorporating more diverse voices in head and neck cancer research.

PI_NAMEs: STOTT, SHANNON L (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Affect;alcohol exposure;anti-cancer research;Architecture;Area;attributable mortality;Biological;Biological Assay;Biology;biomarker development;Cancer Etiology;Carcinogens;Cells;checkpoint inhibition;chemotherapy;Clinical;cohort;Communities;community college;Complex;cost effective;Country;Coupled;Data;Data Set;Deglutition;Demographic Factors;design;Development;Diagnosis;diagnostic biomarker;Disease;Dissociation;Ecosystem;Elements;Environment;epithelial to mesenchymal transition;Epithelium;Exclusion;exhaustion;Exhibits;experimental study;Failure;Goals;Grant;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;health inequalities;Heterogeneity;Histopathology;HPV negative;Hybrids;Image;imaging approach;imaging biomarker;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune Evasion;Immune system;Immunologic Surveillance;Immunotherapy;improved;Individual;innovation;insight;Institution;Invaded;Investigation;Laboratories;Learning;Learning Module;lens;Ligands;Link;Literature;Malignant - descriptor;malignant mouth neoplasm;Maps;Mentors;Mesenchymal;Mesenchymal Cell Neoplasm;Metastatic/Recurrent;Morbidity - disease rate;Morphology;mortality;Mouth Diseases;mouth squamous cell carcinoma;multiple omics;multiplexed imaging;Neoplasm Metastasis;next generation;Ointments;Operative Surgical Procedures;oral biology;Outcome;Pathologic;Pathway interactions;patient stratification;Patient-Focused Outcomes;Patients;Phenotype;Population;portability;predicting response;Prognosis;programs;Proteins;Proteomics;Radiation therapy;Research;Research Personnel;Resource Sharing;responders and non-responders;response;Rewards;RNA;Sampling;Signal Transduction;single-cell RNA sequencing;Smoking;spectrograph;Speech;Stromal Cells;Survival Rate;synergism;T-Lymphocyte;targeted treatment;Techniques;tertiary lymphoid organ;Testing;therapy resistant;Tissues;tobacco exposure;Training;transcription factor;transcriptomics;Translating;Travel;treatment response;treatment stratification;Trust;tumor;tumor heterogeneity;Tumor Markers;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;Visualization;Voice;Work

PROJECT_TITLE: Precision imaging of the spatial regulators of the hybrid epithelial/mesenchymal state in head and neck cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-K (50)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: COLUMBIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The proposed research aims to address health disparity issues prevalent among Asian Americans, the fastest growing racial group in the US, using culturally targeted anti-smoking messages, with focus on high-risk subgroups of Filipino, Korean, and Vietnamese Americans. In the long-term, the findings will inform effective and efficient intervention development in culturally targeted tobacco control by assessing the effect and relative effectiveness of various targeting strategies. The project is relevant to NIMHD’s mission because it will contribute to improving minority health and reduce health disparities by examining how to design effective anti- smoking messages reflecting unique characteristics and cultural values of Asian Americans.

PI_NAMEs: KIM, MINJI  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;American;Antismoking;Asian;Asian Americans;Asian Indian;Attention;Behavior;Behavior assessment;Behavioral;Characteristics;Chinese;Cigarette;Communication;Costs and Benefits;Cultural Sensitivity;cultural values;Data;design;Development;Diabetes Mellitus;Disparity;Effectiveness;effectiveness evaluation;Elasticity;Elements;Equilibrium;Ethnic Population;experimental study;Filipino;Filipino American;Future;Goals;Health;Health behavior;health communication;health disparity;health equity promotion;Health Policy;high risk;Hispanic;improve minority health;Individual;innovation;Interview;Koreans;Latinx population;male;Malignant Neoplasms;Measurement;Measures;Mediator;Methods;Minority Groups;Mission;Modeling;National Institute on Minority Health and Health Disparities;novel strategies;Outcome;Participant;Patient Self-Report;Persuasive Communication;pilot test;Population;population health;Prevalence;Price;primary outcome;Process;programs;Public Health;racial population;Randomized;recruit;Reduce health disparities;relative effectiveness;Reporting;Research;Research Personnel;response;Risk;secondary outcome;Smoker;Smoking;smoking cessation;smoking prevalence;Structure;Subgroup;success;Surface;System;theories;therapy development;Tobacco;tobacco control;Tobacco use;Vietnamese

PROJECT_TITLE: Evaluating culturally appropriate anti-smoking messages for high-risk Asian ethnic subgroups

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Microbiome;Osteoarthritis;Pain Research;Precision Medicine

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Project Narrative The proposed research is relevant to public health because a better understanding of how various microbiome niches increase the risk for osteoarthritis (OA) and/or the development of microbiome-based predictive models for OA clinical care is likely not only to give insights into the causes of OA, but also to give rise to new treatments for OA patients. Thus, this proposal is relevant to the part of the NIH's mission that pertains to fostering fundamental creative discoveries, innovative research strategies, and their applications as a basis for ultimately improving health.

PI_NAMEs: JEFFRIES, MATLOCK  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Affect;Age;age-related disease;Aging;Arthritis;Bacteria;Bacterial DNA;Biological Markers;biomarker development;Blood;Blood specimen;Body mass index;Cartilage;Chronic;Clinical;clinical care;Clinical Trials;clinically relevant;cohort;comparison control;Creativeness;Data;Data Set;deep sequencing;Degenerative polyarthritis;Development;disability;Disease;DNA;Environmental Risk Factor;epigenetic marker;Epigenetic Process;Ethnic Origin;Exhibits;experience;Failure;Fostering;Functional disorder;Future;Genetic;gut microbes;gut microbiome;Health;Hematogenous;Hematogenous Spread;high reward;high risk;Human;improved;Individual;Inflammation;Inflammatory;innovation;insight;Joints;Knee Osteoarthritis;Laboratories;Logistic Models;Machine Learning;machine learning method;Microbe;microbial;microbiome;microbiome research;microbiome sequencing;Mission;model development;Modeling;Mus;Musculoskeletal Diseases;novel;Obesity;Oklahoma;Pain;Pathogenesis;patient population;patient subsets;Patients;Pattern;Peripheral;peripheral blood;Play;Positioning Attribute;potential biomarker;pre-clinical;predictive marker;predictive modeling;Predisposition;Public Health;Publishing;radiological imaging;Recording of previous events;Research;Risk;Risk Factors;Role;Route;Sampling;sex;Sex Differences;Source;Specimen;success;Techniques;Testing;Time;treatment strategy;United States National Institutes of Health;Work

PROJECT_TITLE: The peripheral blood microbiome as a potential biomarker of knee osteoarthritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-L (03)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Neurosciences

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative The purpose of this project is to investigate voice changes associated with speaking in challenging acoustic environments to better inform clinical care for individuals with voice disorders. Many real-life communicative environments include background noise, which poses an obstacle for monitoring and regulating of voice production, especially for those with muscle tension dysphonia. This project, therefore, will fill a crucial theoretical knowledge gap of the underlying mechanisms of the Lombard effect and inform development of individualized clinical assessment and treatment for individuals with sensorimotor deficits underlying their voice disorders.

PI_NAMEs: AARON, ALLISON  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acoustics;Auditory;Behavioral;career;Caring;Clinical;Clinical assessments;clinical care;Clinical Treatment;clinically relevant;clinically significant;Communication;Communication difficulty;Development;Diagnostic;Dysphonia;Educational process of instructing;Environment;evidence base;Excision;experience;Experimental Designs;experimental study;Exposure to;Fatigue;Feedback;Frequencies;Goals;improved;Individual;individualized medicine;insight;Investigation;Knowledge;Life;Link;Loudness;Measures;Modeling;Monitor;Motor;motor control;Muscle Tension;Noise;Occupational;Outcome;Participant;Patient Self-Report;Persons;Phase;Phonation;Process;Production;Ramp;Reporting;Research;response;Restaurants;Sampling;Scientist;Sensorimotor functions;Severities;Shapes;social;spectral energy;Speech;Speech Acoustics;Symptoms;Time;Training;Update;Voice;Voice Disorders;Voice Quality;Work

PROJECT_TITLE: The Lombard effect in muscle tension dysphonia: mechanistic and clinical characterization

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (36)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Nearly 1 in 2 suicide deaths among Hispanic adults involves a firearm, the most lethal suicide method. However, there are critical gaps in characterizing Hispanic firearm suicide deaths and identifying opportunities for preventing firearm suicide among Hispanic adults. Identifying the circumstances preceding firearm suicides among Hispanic adults and generating new information on different typologies of Hispanic adult firearm suicide decedents are critical steps toward developing population-informed and targeted firearm suicide interventions.

PI_NAMEs: GOLDSTEIN, EVAN VICTOR (contact)

PROGRAM_OFFICER_NAME: GOGINENI, ARUNDHATI

PROJECT_TERMS: Address;Adult;Algorithms;Case Fatality Rates;Categories;Cessation of life;Characteristics;Chronic;Clinical;clinical diagnosis;Code;Communities;Coroners and Medical Examiners;Counseling;Data;Demographic Factors;Discrimination;ethnic minority;Ethnic Origin;Evaluation;expectation;experience;Feeling suicidal;Financial Hardship;Firearms;Frequencies;Funding;Future;Gender;Health;Health Disparities Research;Hispanic;Hispanic Populations;improved;Individual;innovation;insight;Intervention;Label;Law Enforcement;Life;Machine Learning;machine learning algorithm;male;Manuals;Mental Health;Mental Health Services;Methods;minority communities;Modeling;Mood Disorders;National Institute on Minority Health and Health Disparities;Natural Language Processing;Natural Language Processing pipeline;Not Hispanic or Latino;Outcome;Ownership;Pain;Patients;Persons;physical conditioning;Population;prevent;Process;Psychopharmacology;Psychotherapy;racial difference;racial minority;Reporting;Research;Research Personnel;Risk Factors;Sampling;Scanning;sex;Subgroup;suicidal behavior;suicidal morbidity;Suicide;Suicide attempt;Suicide prevention;suicide rate;supervised learning;System;Testing;Text;tool;Typology;United States National Institutes of Health;Violence;Work

PROJECT_TITLE: Hispanic Firearm Suicide Decedents: Identifying Circumstances and Typologies with National Violent Death Reporting System Data

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: AMES

ORG_DEPT: GENETICS

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: The overarching goal of the proposed experiments is to create a gene editing method to efficiently introduce small DNA changes into the zebrafish genome for modeling human health. The strategy builds on using homology surrounding CRISPR/Cas9 double-strand breaks for efficient introduction of cargos into the genome. This strategy is expected to have broad utility and function in with high efficiency in other organisms, and thus be broadly applicable to animal models used by the NIH.

PI_NAMEs: ESSNER, JEFFREY J (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Alleles;Animal Model;arm;base editing;Biological Assay;Biological Models;Cells;Coin;Consumption;Cre driver;CRISPR/Cas technology;Data;design;Development;Direct Repeats;disease model;DNA;DNA Integration;DNA Repair Enzymes;dominant genetic mutation;Embryo;Event;experience;experimental study;Frequencies;Gene Delivery;gene-editing approach;Generations;Genes;Genome;Genomics;Germ Lines;Goals;Guide RNA;Health;human disease;human model;in vivo;Injections;Knock-in;Length;Mediating;Messenger RNA;Methodology;Methods;Microinjections;Microscopy;model organism;Modeling;Mutagenesis;next generation;Nucleotides;Oligonucleotides;Optics;Organism;overexpression;Plasmids;prevent;prime editing;Production;Proteins;Reagent;repair enzyme;repaired;Reporter;Reproducibility;RNA;screening;Single Nucleotide Polymorphism;Site;Structure;System;Testing;Time;transmission process;United States National Institutes of Health;Variant;variant of unknown significance;Zebrafish;zebrafish genome

PROJECT_TITLE: Targeted ingression of SNPs into the zebrafish genome

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: SANTA BARBARA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: PROJECT NARRATIVE:  Emotion-regulatory failures are central to mood and anxiety disorders, which afflict over 20% of the adult population in the United States and are challenging to treat. Extant evidence implicates altered function of the lateral prefrontal cortex (LPFC) in these disorders, but the specific contributions of LPFC to adaptive emotion remain poorly understood. The proposed studies harness a combination of state-of-the-art brain imaging analyses and methods that permit causal inference to uncover the roles of distinct LPFC regions in emotional responding and regulation, thereby advancing the development of a model that can be applied to optimize treatment for individuals who suffer from mood and anxiety disorders associated with LPFC dysfunction.

PI_NAMEs: LAPATE, REGINA  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Adult;Advanced Development;Affect;Affective;Amygdaloid structure;Anatomy;Anxiety Disorders;Attenuated;Behavior;Brain imaging;Code;cognitive control;Complex;Data;Disease;emotion regulation;Emotional;emotional functioning;Emotions;Evaluation;Event;Failure;Functional disorder;Functional Magnetic Resonance Imaging;functional MRI scan;Goals;Human;imaging modality;Impairment;Incidence;Individual;innovation;insight;Lateral;Lesion;Major Depressive Disorder;Mental Depression;Mental Health;Modeling;Mood Disorders;Multivariate Analysis;National Institute of Mental Health;Neuroanatomy;Neurocognitive;novel;Personal Satisfaction;Population;Prefrontal Cortex;Process;Regulation;response;Role;Science;showing emotion;Signal Transduction;Specificity;Stimulus;Task Performances;Testing;Time;Transcranial magnetic stimulation;treatment optimization;United States;With laterality;Work

PROJECT_TITLE: Lateral prefrontal organization in emotion: representational and causal mechanisms

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Minority groups including children identified as Black or African American and as Hispanic or Latino, and children who come from low-income families, continue to have lower adherence to the recommended Well- Child preventive care schedule. Focusing on patients who did not attend a scheduled Well-Child visit (“no- showed”), we propose to test and compare text messaging and community health worker outreach as strategies for quickly re-engaging families in care after no-show, and to assess impact for minority groups including families whose preferred language is Spanish. Evaluating effectiveness and cost-effectiveness of both interventions will inform clinical practice and decision-making in healthcare to help ultimately reduce disparities in preventive care.

PI_NAMEs: DEBINSKI, BEATA  (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Academy;Address;Adherence;African American;American;Appointment;Appointments and Schedules;arm;barrier to care;Behavior;behavior change;Black American;Caregivers;Caring;Child;Child Development;Child Health;Child health care;Child Welfare;Childhood;clinical practice;Communities;Community Health Aides;Community Health Systems;cost;Cost Analysis;cost effective;cost effectiveness;cost-effectiveness evaluation;Counseling;Data;data standards;Decision Making;design;Development;Disparity;disparity elimination;disparity reduction;Early Intervention;economic evaluation;Economics;effectiveness evaluation;Eligibility Determination;Emergency department visit;Enrollment;Ensure;Equity;ethnic minority;ethnic minority population;experience;Family;family support;follow-up;Funding;Future;Goals;Grant;Health;Health Care Costs;Health Services Research;Health system;Healthcare;Healthcare Systems;Hispanic;Hospitalization;Human Resources;Immunization;improved;Individual;Institution;Intervention;Language;Latino;Literature;Low Income Population;lower income families;Managed Care;Marketing;Measures;Medicaid;Methods;Minority;minority children;Minority Groups;Modality;Modeling;Motivation;National Institute on Minority Health and Health Disparities;North Carolina;Outcome;outreach;Pathway interactions;Patients;Pattern;Pediatrics;Policies;Population;population health;Positioning Attribute;Preventive;Preventive care;primary outcome;Process;Productivity;Protocols documentation;Provider;racial minority;racial minority population;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Recurrence;Reporting;Research;Resource Allocation;Resources;response;Risk;rural area;Schedule;screening;Seasonal Variations;simulation;social;Spanish;Spanish/English;Standardization;Technology;Testing;Text;Text Messaging;Time;Touch sensation;Transportation;treatment as usual;Trust;Uninsured;uptake;Urban Population;Use Effectiveness;Visit;Well Child Visits;Work

PROJECT_TITLE: Comparing Technological and Relational Approaches to Support Families After a Missed Well Child Visit

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease;Neurosciences;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Aging makes the heart more susceptible to abnormal heart rhythms (arrhythmias) like atrial fibrillation (AF). Despite men and women developing AF at different ages and having different outcomes, little is known about whether there are sex differences in the changes to the atria that happen in aging that predispose to arrhythmias. The goal of this project is to determine sex differences in the atria in aging which may inform future sex-specific strategies for the prevention and treatment of abnormal atrial rhythms.

PI_NAMEs: RIPPLINGER, CRYSTAL MAY;SMITH, CHARLOTTE  (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: 4 year old;Ablation;Acetylcholine;Action Potentials;Acute;adverse event risk;Affect;Age;age difference;Age disparity;Age of Onset;age related;age related changes;age-related disease;aged;Aged, 80 and over;Aging;aging population;Agonist;Animals;Arrhythmia;Atrial Fibrillation;beta-adrenergic receptor;Biochemical;Biochemical Markers;Biological;Biology of Aging;Biophysics;Cessation of life;Characteristics;Clinical Research;Computer Models;Connexins;Data;debilitating symptom;density;Development;Disease;Electrocardiogram;Electrophysiology (science);Etiology;experimental study;Failure;Female;Fibrosis;Future;Generations;Goals;healthy aging;Heart;Heart Abnormalities;Heart Atrium;Heart failure;heart rate variability;heart rhythm;Heterogeneity;Human;human old age (65+);Immunofluorescence Immunologic;in vivo;Individual;insight;Investigation;Ion Channel;Knowledge;male;Maps;mathematical model;Membrane;men;middle age;Modeling;Morbidity - disease rate;morphogens;Morphology;mortality;Muscarinic Acetylcholine Receptor;Muscle Cells;Myocardial Infarction;National Institute on Aging;Nerve;Norepinephrine;normal aging;novel;Optics;Oryctolagus cuniculus;Outcome;Pathologic;Persons;pharmacologic;Phenotype;Play;pre-clinical research;preclinical study;predictive marker;Predisposition;Preparation;Prevalence;Prevention strategy;Process;protein expression;Proteins;Refractory;Research Project Grants;research study;resilience;resilience factor;response;Risk;Risk Factors;Role;sex;Sex Differences;Site;Stains;Stroke;success;Symptoms;Testing;Time;Tissues;Treatment outcome;treatment strategy;voltage;Western Blotting;Woman

PROJECT_TITLE: Investigating sex differences in atrial remodeling and arrhythmia risk in aging

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The early fusion of the cranial sutures, craniosynostosis, is the second most common craniofacial birth defect (1/2500 births). This project seeks to phenotypically, mechanistically and genetically characterize a new zebrafish model of syndromic craniosynostosis, with the goal to obtain critical data for future work to elucidate the pathomechanisms of CRS to develop novel, non-surgical treatment strategies.

PI_NAMEs: HENKE, KATRIN  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Adolescent;Adult;Affect;Alcian Blue;Animal Model;Apoptosis;Birth;bone;Bone Density;Bone Growth;Brain;Calvaria;Candidate Disease Gene;candidate identification;causal variant;Cell Proliferation;Cephalic;Chromosome 2;Clustered Regularly Interspaced Short Palindromic Repeats;Comparative Study;Congenital Abnormality;coronal suture;cost effective;craniofacial;craniofacial development;Craniosynostosis;cranium;Data;Defect;Dermal;Development;Disease;Disease Progression;dominant genetic mutation;Elements;Embryo;Evaluation;Excision;Exhibits;experimental study;Fishes;fluorexon;Formulation;Frequencies;Future;Gene Expression;Gene Mutation;gene network;Genes;Genetic;genetic analysis;genetic linkage analysis;Genetic Screening;genome editing;genome sequencing;Goals;Growth;Hemorrhage;Heterozygote;high risk;human disease;Immunohistochemistry;Impaired cognition;in vivo;in vivo imaging;Incidence;Investigation;Joint structure of suture of skull;Knock-in;Knowledge;Label;Life;Light;Limb structure;Link;Live Birth;malformation;Maps;mechanical properties;Mediating;microCT;Microscopy;Modeling;Modification;Molecular;mutant;Mutation;nanoindentation;nonsynonymous mutation;novel;Operative Surgical Procedures;Osteogenesis;Pathway interactions;Patients;Pattern;Phenocopy;Phenotype;Phosphoproteins;pressure;rapid growth;Regulatory Pathway;Repeat Surgery;Reporter Genes;Scanning;screening;Series;shape analysis;Shapes;Siblings;Signal Pathway;skeletal;skeletal abnormality;Skeletal Development;Skeleton;skull base;small molecule;spatiotemporal;Stains;standard of care;Structure of fontanel of skull;Surgical sutures;suture fusion;targeted treatment;Testing;Time;Tissues;Tooth structure;transcriptome sequencing;transcriptomics;Transgenic Organisms;treatment strategy;Variant;Western Blotting;whole genome;Work;Zebrafish

PROJECT_TITLE: Novel zebrafish model of syndromic craniosynostosis

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW HAVEN

ORG_DEPT: CHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Catalytic C-H bond functionalization has emerged as a powerful approach in organic synthesis for the discovery and production of new pharmaceuticals. The next generation C-H bond functionalization methods described in this proposal will enable the rapid assembly of pharmaceutically relevant compounds, including complex architectures, from simple and readily available inputs. As they are developed, these synthetic methods will be applied to the discovery and optimization of potent and selective ligands to challenging biomolecular targets relevant to the treatment of unmet medical conditions.

PI_NAMEs: ELLMAN, JONATHAN A (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Next-generation C-H functionalization methods for organic synthesis and their applications to biological inquiry


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative: Abdominal aortic aneurysm (AAA) is a life-threatening disease that afflicts ~1.5 million Americans. The progressive dilation of AAA culminates in its fatal rupture, yet there are still no effective therapies other than the risky surgical repairs. For the first time, our study discovered the therapeutic potential of dietary restrictions of single amino acid in preventing AAA in rodents. We further identified a molecular “brake” triggered by such dietary intervention and hence exerted its protection against AAA. The ultimate outcome of this project will lead to the establishment of new paradigms for AAA treatment — through dietary intervention or even drug therapies to activate this molecular “brake”.

PI_NAMEs: WANG, BOWEN  (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: abdominal aorta;Abdominal Aortic Aneurysm;activating transcription factor 3;Adopted;American;Amino Acids;Angiotensin II;Aorta;Arginine;Arginine deiminase;Automobile Driving;Biological;Biological Assay;Caloric Restriction;Cardiovascular Diseases;Cell Survival;Cells;Clinical;Clinical Management;Co-Immunoprecipitations;combat;cost;Cytoprotection;Development;Diameter;dietary;Dietary Intervention;dietary restriction;Disease;effective intervention;effective therapy;Elastases;Elderly;Exhibits;Functional disorder;gain of function;Gender;Genetic Transcription;Health;Health Benefit;Homeostasis;Human;In Vitro;in vivo;Inflammatory;innovation;Intervention;Intervention Studies;knock-down;Knock-out;Knockout Mice;Lead;Lesion;Leucine;Life;loss of function;Mediating;Medical;Metabolic stress;Methionine;Modeling;Molecular;mortality;multi-ethnic;Mus;mutant;Mutation;Newly Diagnosed;novel;Operative Surgical Procedures;Outcome;Paracrine Communication;Pathogenesis;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Phosphotransferases;Pilot Projects;Play;Population;Post-Translational Protein Processing;prevent;Prevention;Proteins;Rattus;Recombinant Proteins;Regulation;repaired;Repression;Resistance;response;Risk Reduction;Rodent;Role;Rupture;screening;Signal Transduction;Smooth Muscle Myocytes;Specimen;Starvation;stress kinase;success;Testing;Therapeutic;Time;transcription factor;Transgenic Organisms;Vascular Smooth Muscle

PROJECT_TITLE: The Role of Amino Acid Starvation Response Kinase GCN2 in Abdominal Aortic Aneurysm

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE This project is important for public health as it endeavors to establish the first online knowledgebase platform encompassing all neurometabolic diseases. This platform aims to allow doctors and scientists free access to valuable information to improve their understanding of these conditions, improve patient care, establish consensus on clinical management, and provide invaluable data to expand research endevours. Consequently, this project aligns with the NIH’s mission to reduce illness and disability.

PI_NAMEs: MARIN-VALENCIA, ISAAC  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Adherence;age group;Area;Artificial Intelligence;base;Basic Science;Biochemical;Biochemical Markers;Biochemical Pathway;Bioinformatics;bioinformatics resource;Birth;Brain;Caring;Case Study;Categories;Cessation of life;Characteristics;Chemicals;Classification;Clinical;Clinical Data;Clinical Management;Clinical Trials;Collaborations;Consensus;cost;Data;Data Analyses;Data Analytics;Databases;Dedications;Defect;design;Development;Diagnostic;disability;Disease;disease classification;Disorder of neurometabolic regulation;Education;effective intervention;empowerment;Ensure;epidemiologic data;Epidemiology;Exhibits;experience;Family;Feedback;Financial Support;Funding;General Practitioners;Genes;Genetic;Genetic Diseases;Goals;Grant;Guidelines;Health Professional;Human;Impairment;improved;Incidence;Infrastructure;Inherited;innovation;insight;International;Intervention;Intuition;knowledgebase;Laboratories;Lesion;Maps;Mass Spectrum Analysis;mathematical analysis;Medical;medical schools;Meta-Analysis;Metabolic;Metabolic Diseases;Metabolic Pathway;Mission;multidisciplinary;Names;Nature;neglect;Nervous System;Nervous System Physiology;Neurobiology;neuroinformatics;Neurologic;Neurologic Deficit;Neurologic Symptoms;Neurologist;next generation sequencing;Nomenclature;Nutrient;Online Mendelian Inheritance In Man;Ontology;open source;operation;Outcome;Pathway interactions;Patient Care;patient population;Patients;Pharmaceutical Preparations;Phenotype;Physicians;premature;Premature Mortality;Production;Provider;Psychiatrist;Public Health;PubMed;radiological imaging;Radiology Specialty;Registries;repository;Research;Research Personnel;scale up;Scientist;side effect;Signs and Symptoms;Site;Software Engineering;Standardization;Structure;Symptoms;System;Technology;Therapeutic;Time;tool;Training;Translating;United States National Institutes of Health;Universities;Update;user-friendly;Visual;Visualization;Waste Products;web app;web portal

PROJECT_TITLE: Universal Database for Neurometabolic Diseases

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: 2. PROJECT NARRATIVE Stanford's RAMP UP program combines career awareness activities with an 8-week summer internship for underrepresented minority/first generation high school students, aimed at addressing diversity and opportunity gaps in oral healthcare professions.

PI_NAMEs: GAUDILLIERE, DYANI ;HELMS, JILL A (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Achievement;Address;African American;American;American Dental Association;Biology;care outcomes;career;career awareness;Career Choice;Categories;cohort;college;Communication;community building;community college;Coupled;craniofacial;Curiosities;Data;demographics;Dental;Dental Assistants;Dental Education;Dental Faculty;Dental Hygiene;Dental Hygienists;Dental Research;Dental Schools;Dental Students;Dentistry;Dentists;design;Destinations;Development;direct application;disability;Discipline;Diverse Workforce;Doctor of Philosophy;Educational Curriculum;Educational workshop;Emotional;Empathy;Ensure;Equity;equity, diversity, and inclusion;ethnic diversity;ethnic minority;Evaluation;experience;Faculty;falls;Family;Feedback;Friends;Funding;Generations;Goals;Grant;health care availability;Health Professional;Healthcare;high school;High School Student;Human Resources;improved;improved outcome;Individual;Institution;interest;International;Internships;Knowledge;laboratory experience;Laboratory Research;Lead;Leadership;Learning;Low income;Medicine;Mentors;Mentorship;Modeling;National Institute of Dental and Craniofacial Research;Native Americans;Operative Surgical Procedures;Oral health;Participant;Pathway interactions;peer support;people of color;Persons;Policies;Population;Positioning Attribute;Process;programs;Quasi-experiment;recruit;regenerative;Regenerative Medicine;Reproducibility;Research;Research Activity;research and development;Research Personnel;Research Project Grants;resilience;Resource-limited setting;Rest;school district;Schools;Science;Scientist;Services;skills;social;Students;success;Suggestion;summer internship;summer program;summer research;symposium;teacher;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;underserved community;Underserved Population;university student;Vocational Education;Woman;Youth

PROJECT_TITLE: Research and Mentoring Program for Underrepresented Pre-dental students (RAMP UP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 TO (21)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Data Science;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: HANOVER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative Title: Characterizing Information Needs and Peer Engagement Regarding Medication for  Opioid Use Disorder on social media Although medications for opioid use disorder (MOUD) are the most effective, evidence-based treatment for OUD, there remain significant knowledge gaps and misperceptions regarding these medications that adversely impact treatment initiation, adherence, and retention. Social media platforms like Reddit contain millions of self-reported narrations on critical MOUD-related treatment information needs and how thousands of individuals with lived experiences address them. By utilizing advanced natural language processing and novel mixed-method solutions on large-scale, population-level Reddit data, this exploratory project aims to characterize clinically relevant MOUD treatment information needs to inform the design of tailored communication programs and interventions (e.g., chatbot) and ultimately improve MOUD treatment access and quality.

PI_NAMEs: PREUM, SARAH MASUD  (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Access to Information;Address;Adherence;Affect;Area;Buprenorphine;Cessation of life;chatbot;Classification;Clinical;clinically relevant;Code;Communication Programs;Complement;Complex;Computing Methodologies;Consult;Data;Data Analytics;Data Science;Data Set;deep learning;Dependence;design;effective therapy;Evidence based treatment;Face;Facebook;Formulation;Foundations;Frequencies;Future;gigabyte;Goals;Health;Health Care Costs;Health Personnel;Health Services Accessibility;improved;Individual;Information and Media;innovation;insight;Institution;Intervention;intervention program;Knowledge;large datasets;Lived experience;medication for opioid use disorder;member;Metadata;Methadone;Methodology;Methods;Misinformation;Modeling;mortality;multidisciplinary;Narration;National Institute of Drug Abuse;Natural Language Processing;Nature;novel;Opioid;opioid epidemic;opioid overdose;opioid use disorder;Outcome;Patient Self-Report;peer;peer support;personalized intervention;Persons;Pharmaceutical Preparations;Pilot Projects;Population;Process;Productivity;Protocols documentation;Published Comment;Qualitative Methods;Recovery Support;Reporting;Research;Resources;Science;Series;social media;social stigma;Stigmatization;Suboxone;Substance Use Disorder;success;Text;treatment strategy;Trust;Work

PROJECT_TITLE: Characterizing Information Needs and Peer Engagement Regarding Medication for Opioid Use Disorder on Social Media

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PI_NAMEs: STAMATATOS, LEONIDAS  (contact)

PROGRAM_OFFICER_NAME: POOLE, STEVEN THOMAS

PROJECT_TERMS: Antigens;B-Lymphocytes;Cells;Complex;COVID-19 vaccine;Cyclic GMP;Excipients;experience;Funding;Goals;HIV-1;Human;in vivo;manufacture;Membrane;nanoparticle;Nanostructures;operation;Pharmaceutical Preparations;Positioning Attribute;Process;programs;response;RNA;RNA amplification;RNA vaccine;Sterility;structured lipid;vaccine candidate;Vaccines;Vial device;Yellow Fever


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Opioid Misuse and Addiction;Opioids;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE Substance us disorder (SUD) and overdose is a national top-three leading cause of pregnancy-associated death, and historically marginalized patients are at greatest risk of overdose or death due to inequitable barriers to treatment retention. Contingency management is one of the most effective incentive-based interventions to improve SUD outcomes, but is understudied and rarely used in the obstetric population. We propose to design and conduct a hybrid efficacy-implementation randomized control trial to test the efficacy of CM after standardized assessment and management of social needs within a SUD-specific prenatal clinic, to improve treatment retention and other SUD/obstetric outcomes and moderate the relationship between social determinants of health and SUD outcomes; implementation outcomes will additionally be assessed for scalability and sustainability in health policy.

PI_NAMEs: BAUMANN WALKER, ANA ;KELLY, JEANNIE CHEN (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Abstinence;acceptability and feasibility;addiction;Address;Adherence;Adoption;Affect;barrier to care;Behavior Therapy;Cessation of life;Child Custody;Clinic;Clinical;Code;community advisory board;Consultations;contingency management;Data;design;Discipline of obstetrics;Disease;Documentation;Economics;effective intervention;efficacy evaluation;efficacy testing;empowerment;Equity;Exercise;Face;Failure;Family;Feedback;Focus Groups;Health;health assessment;Health Expenditures;Health Policy;Health Services;Helping to End Addiction Long-term;Hybrids;implementation evaluation;implementation outcomes;implementation science;improved;incentive-based intervention;Incentives;Inequity;informant;International Classification of Disease Codes;Intervention;Interview;Link;Maintenance;Maps;marginalization;maternal morbidity;Methods;Modeling;Morbidity - disease rate;neonatal outcome;obstetric outcomes;Opiate Addiction;Opioid;opioid misuse;Outcome;Overdose;overdose risk;Participant;patient engagement;Patient Recruitments;patient retention;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Policies;Population;Postpartum Period;Pregnancy;pregnancy related death;pregnant;prenatal;Prenatal care;primary outcome;programs;Protocols documentation;Provider;Public Health;Publishing;Randomized;Randomized, Controlled Trials;Records;Recovery;recruit;Research;retention rate;Science Policy;Screening procedure;secondary outcome;Services;Severities;social;social health determinants;Social Work;Speed;Standardization;Structure;substance use;Substance Use Disorder;Surveys;Testing;Tobacco Use Cessation;treatment as usual;treatment risk;treatment strategy;United States National Institutes of Health;Universities;Visit;Visiting Nurse;Washington;Work

PROJECT_TITLE: Substance Use in Pregnant People - Optimizing Retention in Treatment by Maximizing Opportunities for Management (SUPPORT-MOM)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-E (O1)]


ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE The Center for Viral Systems Biology (CViSB) proposes to host the 2024 annual meeting in San Diego on September 25th and 26th, 2024. The goal of the annual meeting is to report progress, seek new research directions and ideas, and update NIAID on issues of need. The speciﬁc aim of the supplement is to provide the event space, and resources needed to accomplish these goals.

PI_NAMEs: ANDERSEN, KRISTIAN GRAUGAARD (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: California;Collaborations;Communicable Diseases;Communication;Dedications;Development;Event;Fostering;Funding Mechanisms;Goals;Infectious Diseases Research;Leadership;meetings;member;National Institute of Allergy and Infectious Disease;Persons;programs;Progress Reports;Reporting;Research;Research Personnel;Resources;Systems Biology;Time;United States National Institutes of Health;Update;Viral

PROJECT_TITLE: Consortium for Viral Systems Biology (CViSB)


NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Osteoporosis;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: PROJECT NARRATIVE Craniofacial fibrous dysplasia (FD) is one of the more common genetic skeletal dysplasias and is associated with significant morbidity, including vision loss, hearing impairment, dysmorphic facies, fractures and pain. In this proposal, we aim to elucidate the role of TGF-b signaling in driving the fibrotic and excessive bone phenotype associated with FD. The knowledge gained through this proposal can be used to shed light on the pathogenesis of craniofacial FD and identify treatment targets for this disease as well as other diseases of impaired bone growth, including osteoporosis and delayed fracture healing.

PI_NAMEs: WENTWORTH, KELLY LEE (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Affect;Antibodies;Applications Grants;Attenuated;Automobile Driving;Blindness;bone;bone fracture repair;Bone Growth;bone quality;Bone Resorption;Cell Lineage;Cells;Clinical Trials;Collecting Cell;comorbidity;Coupling;craniofacial;craniofacial bone;craniofacial structure;curative treatments;Cyclic AMP;Data;Dental;Deposition;Development;Disabling;disabling disease;Disease;disease model;effective therapy;efficacy testing;experimental study;Extracellular Matrix;Facial asymmetry;Facies;Femur;Fibroblasts;Fibrosis;Fibrous Dysplasia;Fracture;Future;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Expression;gene synthesis;Genes;Genetic;Goals;Growth;Growth Factor;guanine nucleotide binding protein;hearing impairment;Heterotopic Ossification;Histology;Human;human data;Hyperpigmentation;Immunohistochemistry;Impairment;In Vitro;in vivo;induced pluripotent stem cell;inhibitor;Jaw Abnormalities;Kidney;Knowledge;Lesion;long bone;Lung;Maintenance;McCune-Albright Syndrome;Medical;Mesenchymal;Metabolic;microCT;Modeling;Morbidity - disease rate;mosaic;mouse model;Mutation;Myelofibrosis;nano-string;Neural Crest;novel;Organ;Osteitis Fibrosa Disseminata;osteoblast differentiation;Osteoblasts;Osteogenesis;osteogenic;Osteoporosis;osteoprogenitor cell;Pain;Pathogenesis;Pathway interactions;Phenotype;Polyostotic fibrous dysplasia;Precocious Puberty;Proliferating;repaired;response;rib bone structure;Role;Series;serological marker;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;skeletal;Skeletal Development;skeletal disorder;skeletal dysplasia;Skeleton;Skin;skin lesion;Stromal Cells;Testing;therapeutic target;Tissues;Transforming Growth Factor beta;Western Blotting

PROJECT_TITLE: Elucidating the Role of TGF-Beta Signaling in Craniofacial Fibrous Dysplasia of the Bone


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: ORANGEBURG

ORG_NAME: NATHAN S. KLINE INSTITUTE FOR PSYCH RES

PHR: PROJECT NARRATIVE  This project aims to understand the role of a new type of abnormal electrical activity in Alzheimer’s disease (AD): high frequency oscillations (HFOs). HFOs are known to occur in epilepsy but their role in AD remains unknown. Based on pilot data, we hypothesize that HFOs in AD start as a local electrical disturbance in the hippocampus, and as disease progresses, they progressively expand into superficial cortex. We will address this hypothesis using multi-electrode arrays and longitudinal recordings as the animal ages. Finally, we will test whether HFOs contribute to impaired memory, a major AD symptom as well as to AD neuropathology. To that end, we will use two novel strategies that our preliminary data suggest we can disrupt HFOs in vivo either by employing closed-loop optogenetics or by overexpressing a specific K+ channel to also gain novel insights about mechanisms contributing to HFOs in AD.

PI_NAMEs: LISGARAS, CHRISTOS PANAGIOTIS (contact)

PROGRAM_OFFICER_NAME: THOMAS, CIBU PAUL

PROJECT_TERMS: Address;Affect;Age;Age Months;Algorithms;Alzheimer's Disease;Alzheimer's disease model;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Animals;Area;Biological Markers;Blood;Brain;Brain Diseases;brain electrical activity;Cerebrum;Clinical;Data;density;dentate gyrus;Disease;Disease Progression;early detection biomarkers;Electrodes;Electroencephalography;Epilepsy;epileptiform;Event;Exhibits;experimental study;flexibility;Foundations;Functional disorder;Future;gene therapy;Goals;High Frequency Oscillation;Hippocampus;Human;Image;Impairment;Implant;improved;improvement on sleep;in vivo;insight;Investigation;Life;Location;Memory;memory consolidation;Memory impairment;Methods;Modeling;mouse model;multi-electrode arrays;Mus;neuropathology;neurotechnology;new therapeutic target;non rapid eye movement;novel;novel strategies;optogenetics;overexpression;Performance;postnatal;Potassium Channel;Protocols documentation;Repressed Memory;Role;Seizures;Senile Plaques;Sleep;Sleep Stages;Solid;Source;spatiotemporal;Stains;Symptoms;Testing;Tg2576;Time

PROJECT_TITLE: High frequency oscillations in Alzheimer's disease

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Aging;Aphasia;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Mild post-stroke aphasia (operationally defined as a Western Aphasia Battery – Revised Aphasia Quotient > 85) is often disabling but proven treatments are lacking. We propose to use electrical field modeling to optimize TMS stimulation intensity in a double-blind study of continuous Theta Burst Stimulation combined with modified Constraint Induced Language Therapy to treat chronic mild post-stroke aphasia. As a secondary aim, we will explore the effects of the treatment on non-linguistic cognitive functions and assess their role in the genesis of the communication impairment in mild aphasia.

PI_NAMEs: COSLETT, H BRANCH (contact);MARTIN, NADINE

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Affect;Aftercare;Age;Anatomy;Aphasia;Attention;Behavioral;behavioral neurology;brain magnetic resonance imaging;Chronic;chronic stroke;Clinical;cognitive ability;cognitive function;cognitive neuroscience;cognitive testing;Communication;Communication difficulty;Communication impairment;Complex;Data;Disabling;Double-Blind Method;electric field;Evaluation;executive function;Exploratory/Developmental Grant;Functional Magnetic Resonance Imaging;Impairment;improved;Individual;Investigation;Language;Language Therapy;Left;Lesion;lexical;Literature;Location;Measures;Mediating;Memory;Modeling;MRI Scans;neuroregulation;Nonverbal Communication;Outcome Measure;outcome prediction;Participant;Performance;Persons;post stroke;predicting response;primary outcome;Probability;Randomized;Reporting;Rest;Role;Severities;Short-Term Memory;Site;social situation;Speech;Speech Therapy;Stroke;stroke-induced aphasia;theories;therapy design;Time;Transcranial magnetic stimulation;treatment duration;treatment effect;treatment response;verbal;Word Processing;Work

PROJECT_TITLE: Personalized Transcranial Magnetic Stimulation and Constraint Induced Language Therapy to Treat Mild Post-Stroke Aphasia

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Biomedical Imaging;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: R21: Human Craniosynostosis Atlas (HuCA) : Standardizing & Establishing a Public Repository for Genomic and Imaging data. Project Narrative: The Human Craniosynostosis Atlas (HuCA) ultimately seeks to create a standardized data resource for unparalleled characterization of craniosynostosis in humans including multi- modality neuroimaging (CT, multi-contrast MRI) and genotyping, all housed in an established NIH repository and made publicly available. By establishing the standardized data protocols, other craniofacial centers will be able to contribute data that can be analyzed in concert across sites, allowing comprehensive sampling of patients across phenotypic presentations. HuCA is a critical step in deeper characterization of a disease that can lead to discovery of clinically relevant associations between head shape, brain health & genotype which will fundamentally impact how we treat craniosynostosis.

PI_NAMEs: GOLINKO, MICHAEL S;NEWTON, ALLEN T (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Affect;anatomic imaging;animal data;Animal Model;archived data;Atlases;biobank;Biological;Biological Assay;Brain;brain health;Brain Injuries;Breathing;Cephalic;Cheek structure;Child;Child Development;Clinical;clinical care;Clinical Data;clinically relevant;cognitive development;cohort;Communities;Complement;Cosmetics;craniofacial;Craniosynostosis;Data;data access;data acquisition;data exchange;data resource;Data Set;data standards;Databases;Development;Diagnosis;Dimensions;Disease;disease classification;Dose;Eating;FaceBase;file format;Functional Magnetic Resonance Imaging;Funding;genome repository;genome sequencing;genomic data;Genomics;Genotype;Goals;Growth;Head;Human;human data;Image;Impaired cognition;improved;Individual;individual patient;Infant;Infrastructure;interest;Internet;Intuition;Joint structure of suture of skull;Knowledge;Left;Life;low dose computed tomography;Magnetic Resonance Imaging;Metadata;multimodal neuroimaging;National Institute of Dental and Craniofacial Research;Neurocognitive;neuroimaging;operation;Operative Surgical Procedures;Outcome;Output;Parents;Pathway interactions;Patients;Perfusion;Phenotype;Policies;Population;premature;Privacy;protocol development;Protocols documentation;public repository;Quality Control;recruit;repository;Research Personnel;Resources;respiratory;response;Rest;saliva sample;Sample Size;Sampling;shape analysis;Shapes;Site;skeletal;standard of care;Standardization;Structure;Surgical sutures;suture fusion;Swab;synergism;Testing;United States National Institutes of Health;Variant;Vendor;Vision;web portal;web site;whole genome;X-Ray Computed Tomography


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Brain Disorders;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Down Syndrome;Eye Disease and Disorders of Vision;Intellectual and Developmental Disabilities (IDD);Pediatric

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project narrative We will investigate if individuals with Down syndrome (DS) are predisposed to develop Sjogren’s-like disease (SjD) using the DS mouse model Dp16 mice, which will be treated with agonists of toll-like receptors (TLR) and interferon stimulation (e.g. DMXAA) to address if they develop enhanced SjD.

PI_NAMEs: LACRUZ, RODRIGO S. (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Address;Affect;aging population;Agonist;Autoantibodies;Autoimmune Diseases;Case Study;Chromosome 21;Chronic;comorbidity;Data;Dimethylxanthenone Acetic Acid;Disease;Down's Syndrome;Gene Cluster;Genetic;Gland;Goals;Human Chromosomes;Hyperactivity;improved;Individual;Inflammation;Inflammatory Response;inhibitor;Intellectual functioning disability;Interferon Activation;Interferon Receptor;Interferons;lacrimal;Life Expectancy;Link;Lymphocytic Infiltrate;middle age;Molecular;mouse model;Mus;Oral;parent grant;parent project;Patients;Persons;Quality of life;Reporting;response;Saliva;saliva secretion;Salivary;Salivary Glands;Serum;Sialadenitis;Signal Transduction;Sjogren's Syndrome;Syndrome;Testing;TLR7 gene;TLR8 gene;Toll-like receptors;Trisomy;Xerostomia

PROJECT_TITLE: Molecular mechanisms of oral deficiencies in Down syndrome


ADMINISTERING_IC: AT

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Microbiome;Natural Products;Nutrition

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: PROJECT NARRATIVE Terpenoids and carotenoids are naturally occurring small molecules with diverse structures and a growing appreciation of their health impacts. Computer algorithms predict that human gut bacteria can produce these molecules, but their impacts on human health are unknown. This work will use high-throughput screening to reveal whether gut bacteria can make terpenoids and carotenoids, and measure their effects on human colon cells.

PI_NAMEs: CROOK, NATHAN C. (contact);EROGLU, ABDULKERIM

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: absorption;Active Biological Transport;Anabolism;Analytical Chemistry;Anti-Inflammatory Agents;Antibiotics;Antioxidants;Atherosclerosis;Bacteria;Bacteriophages;Beta Carotene;Biochemical;Biochemical Pathway;Biological;Biological Assay;Carotenoids;Carrots - dietary;Cells;Chemistry;Chronic;Colon;Computational algorithm;Consumption;Coupled;cytokine;Data;Derivation procedure;Diet;dietary;Dietary Carotenoid;Diffusion;drug metabolism;Enzymes;Epithelial Cells;Epithelium;Escherichia coli;Exhibits;experimental study;fecal microbiome;Fermentation;fungus;gut bacteria;gut dysbiosis;gut inflammation;gut metagenome;gut microbiome;gut microbiota;Health;high throughput screening;Histidine;Human;Human Microbiome;human subject;Immunity;Immunologics;immunoregulation;improved;Inflammasome;Inflammation;Inflammatory;intestinal barrier;Investigation;Isoprene;Kinetics;Knowledge;Libraries;lipid metabolism;Measures;Metabolic;Metabolic Diseases;Metabolism;metagenome;Metagenomics;Methods;microbial;microbiota;Mining;Molecular;mouse model;Natural Products;novel;Obesity;Oxidoreductase;Pathway interactions;Phosphoric Monoester Hydrolases;phytoene;Plants;prediction algorithm;Prevalence;Prevotella;Process;Proteins;Proteomics;Publishing;Reaction;Research Personnel;secondary metabolite;Signal Pathway;Small intestine mucous membrane;Small Intestines;small molecule;Structure;Supporting Cell;Techniques;terpene synthase;Terpenes;Testing;transcription factor;Tretinoin;Vitamin A;Weight Gain;Work;Xenobiotic Metabolism

PROJECT_TITLE: PHAGE-ENABLED MINING OF GUT METAGENOMES FOR TERPENOID AND CAROTENOID METABOLISM

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Pediatric transplant cardiologists have minutes to decide if a donor heart is a good fit for their patient, a process that involves analyzing over a hundred interconnected variables without the help of data-driven guidelines or risk calculators. We are developing machine learning–based models and an easy-to-use interface to help clinicians predict individualized risk and make informed decisions under severe time constraints. This new approach could increase transplant efficiency and revolutionize transplant acceptance practices.

PI_NAMEs: MCCULLOCH, MICHAEL A. (contact);PORTER, MICHAEL DAVID

PROGRAM_OFFICER_NAME: LOMOTAN, EDWIN A

PROJECT_TITLE: Improving Pediatric Donor Heart Utilization with Predictive Analytics

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Neurosciences;Substance Misuse

ORG_CITY: TALLAHASSEE

ORG_DEPT: NUTRITION

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Intake of excessive amounts of alcohol over a prolonged period is detrimental to health with skeletal muscle commonly being affected. The goal of this research is to determine whether alcohol causes muscle weakness through its dysregulation of the skeletal muscle clock and circadian rhythms. Determining how alcohol influences circadian rhythms in the muscle could lead to the discovery of novel targetable pathways to prevent or remediate the negative effects of alcohol on skeletal muscle, which is functionally important for movement, metabolism, and overall quality of life.

PI_NAMEs: STEINER, JENNIFER LYNN (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Abstinence;Acetaldehyde;Acetates;Acute;Address;Adult;Affect;Alcohol consumption;alcohol effect;alcohol exposure;alcohol measurement;Alcoholic Intoxication;Alcoholic Liver Cirrhosis;Alcoholic Liver Diseases;alcoholic myopathy;Alcohols;Alzheimer's Disease;Behavior;Bioluminescence;Blood;Brain;Chronic;chronic alcohol ingestion;circadian;Circadian Dysregulation;Circadian Rhythms;Circulation;Consumption;Cues;Development;Diet;Disease;disorder risk;Dose;Economics;Equilibrium;Ethanol Metabolism;Etiology;Feedback;Fiber;Foundations;functional decline;Functional disorder;Genes;Genetic;Genetic Transcription;Goals;Hand Strength;Health;high reward;high risk;Human;Impairment;In Situ;In Vitro;in vivo;Intake;Investigation;Knowledge;Lentivirus;Liquid substance;Luciferases;Mediating;Metabolic;Metabolic Diseases;Metabolism;Modality;Molecular;molecular clock;Morbidity - disease rate;mortality;mouse model;Movement;Mus;Muscle;Muscle Fibers;muscle metabolism;Muscle Weakness;Muscular Atrophy;Myopathy;new therapeutic target;novel;Output;Pathway interactions;Periodicity;Peripheral;pharmacologic;physiologic model;Physiological;prevent;preventive intervention;problem drinker;Production;programs;Proteins;Quality of life;remediation;Reporting;Research;Role;Signal Induction;Signal Transduction;Skeletal Muscle;Societies;suprachiasmatic nucleus;System;Tamoxifen;Techniques;Testing;Therapeutic Intervention;therapeutically effective;Tissues;Transfection;Translations;Work

PROJECT_TITLE: Alcohol and the skeletal muscle clock

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PI_NAMEs: ACHARYA, PRIYAMVADA  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TITLE: Administrative Core


PI_NAMEs: BLASI, MARIA  (contact)

PROJECT_TITLE: Developmental Core


PROJECT_TITLE: Core 1 - Structural Biology Core


PI_NAMEs: HENDERSON, RORY  (contact)

PROJECT_TITLE: Core 2 - Computational Biology Core


PI_NAMEs: CAIN, DEREK WILSON (contact)

PROJECT_TITLE: Core 3 - Immunobiology Core


NIH_SPENDING_CATS: HIV/AIDS

PROJECT_TITLE: Project 1 - Molecular Dynamics of HIV-1 Entry: Visualizing Transient Intermediates


PI_NAMEs: ALAM, S. MUNIR  (contact)

PROJECT_TITLE: Project 2 - B cell antigen receptor structure and antigen-BCR interaction dynamics


PROJECT_TITLE: Project 3 - Dynamics of latent HIV-1 reservoirs: High resolution antigenic mapping and strategies to block rebound


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The escalating use of kratom, an herbal substance with opioid-like properties, has raised significant public health concerns due to its potential for abuse and dependence. Preclinical studies report inconsistent effects of the psychoactive constituents of kratom in models of reward. The current human abuse potential study will provide foundational data in determining the risks and dose range of kratom to be evaluated for possible benefits.

PI_NAMEs: VERRICO, CHRISTOPHER D (contact)

PROGRAM_OFFICER_NAME: REISSIG, CHAD

PROJECT_TITLE: A human abuse potential study of kratom

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDER-T (09)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MIAMI

ORG_NAME: MIAMI VA HEALTH CARE SYSTEM

PHR: Type 2 Diabetes (T2D) is characterized by defective adaptation of β-cells to insulin resistance. Most of the research effort has focused on elucidating the physiological, molecular, and genetic components that regulate β-cell mass and insulin secretion, presenting diabetes as a unihormonal disorder. Contrary to this approach, clinical data and animal experiments have shown that alterations in glucagon secretion and α-cell mass play a role in the pathogenesis of hyperglycemia in diabetes and responses to hypoglycemia in patients with diabetes. The goal of this application is to understand how nutrient signaling regulates glucagon secretion and α-cell mass in an effort to develop novel therapies for diabetes and control the incident of hypoglycemia, a limitans factor for optimal diabetes control. These agents could be used in translational experiments to treat diabetes and hypoglycemia by controlling glucagon secretion.

PI_NAMEs: BERNAL-MIZRACHI, ERNESTO  (contact)

PROJECT_TERMS: Acids;Affect;Alpha Cell;Amino Acids;Animal Experiments;antagonist;anterior chamber;B-Lymphocytes;Beta Cell;blood glucose regulation;Cell Line;Cells;Chronic;Clinical Data;Complex;Data;Defect;design;diabetes control;diabetes management;Diabetes Mellitus;diabetes mellitus therapy;diabetogenic;Disease;drug development;EIF4EBP1 gene;Equilibrium;Exhibits;experimental study;Eye;FRAP1 gene;Functional disorder;Funding;Generations;Genetic;Genetic Models;Glucagon;Glucagon Receptor;Glucose;glucose metabolism;Goals;Health;Human;human model;hyperglucagonemia;Hyperglycemia;Hypoglycemia;IGFBP2 gene;improved;in vivo;Individual;insight;Insulin;Insulin Receptor;Insulin Resistance;insulin secretion;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans Transplantation;Knowledge;Liver;Metformin;Modeling;Molecular;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutics;Nutrient;Obesity;Overnutrition;Pathogenesis;Pathway interactions;Patients;physiologic model;Physiological;Play;Predisposition;prevent;Publishing;Receptor Signaling;reconstitution;Regulation;Research;response;Rodent Model;Role;Signal Pathway;Signal Transduction;Sirolimus;Testing;therapy design;Time;TSC1 gene;TSC2 gene;Uncertainty;Veterans

PROJECT_TITLE: mTOR signaling and regulation of alpha-cell mass and function