ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition

ORG_CITY: CHAPEL HILL

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Chronic intestinal scarring and thickening, termed intestinal fibrosis, afflicts up to 40% of Crohn’s disease (CD) patients, yet there is no known cure and few treatment options. The fundamental processes underlying CD-associated fibrosis are unknown, partly due to the lack of relevant animal models that recapitulate this complex disease process. Our lab has developed a novel CD inflammation-associated fibrosis model driven by a metal-binding small molecule of the gut microbiota. The objective of this project is to define the mechanisms by which this metal-binding molecule promotes fibrosis and link microbial metal scavenging with fibrogenic disease.

PI_NAMEs: ARTHUR, JANELLE C (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Adherent Invasive Escherichia coli;Affinity;Animal Model;antimicrobial;Bacteria;Binding;Cell surface;cell type;Cells;Cessation of life;chelation;Chronic;Cicatrix;Clinical;clinically relevant;Coculture Techniques;Colon;Communicable Diseases;comorbidity;Complex;Complication;Crohn's disease;Cues;Data;Development;Diagnostic;Diet;dietary;Disease;disease phenotype;dysbiosis;effective therapy;Escherichia coli;Event;Excision;Exhibits;experience;Fibroblasts;fibrogenesis;Fibrosis;fighting;functional plasticity;Gene Cluster;Genes;Gnotobiotic;Goals;gut inflammation;gut metagenome;gut microbiota;Histologic;Homeostasis;host microbiota;Human;Human Microbiome;in vivo;Individual;Inflammation;Inflammatory Bowel Diseases;Innate Immune System;Interleukin-10;Intestinal Fibrosis;Intestines;Iron;iron deficiency;Lesion;Link;Literature;Macrophage;Macrophage Activation;Mediating;Mesenchymal;metagenome;Metagenomics;Metals;Microbe;microbial;microbial community;microbial products;microbiota;Modeling;Molecular;Molecular Profiling;monocyte;mouse model;Mus;mutant;Myelogenous;novel;Nutrient;Organism;Patients;Phagocytosis;Phenotype;Population;preference;Process;Production;Profibrotic signal;prognostic;Public Health;receptor;Repression;response;Role;small molecule;Specificity;Starvation;Supplementation;Testing;Therapeutic;tissue repair;Tissues;tool;Transcript;Transition Elements;uptake;Variant;Work;yersiniabactin;Zinc;Zinc deficiency

PROJECT_TITLE: Microbiota-mediated fibrotic remodeling in the inflamed intestine

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Lung;Pediatric;Precision Medicine

ORG_CITY: KANSAS CITY

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

ORG_STATE: MO

PHR: Project Narrative These studies will validate and test Histamine Iontophoresis with Laser Doppler monitoring in the prediction of treatment response to an antihistamine in pediatric asthma. These studies will validate the first biomarker for use in guiding asthma treatment in children. The success of this research will allow personalized guidance to asthma treatment and ultimately lead to overall improved asthma outcomes in children.

PI_NAMEs: JONES, BRIDGETTE L. (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: Adrenal Glands;Adverse effects;African American;Allergens;Allergic;Antibody Therapy;Antihistamines;Asthma;Biological Markers;Biological Response Modifiers;biomarker validation;Blood;Bronchoconstriction;Caucasians;Cell Adhesion Molecules;Cessation of life;chemokine;Chemotaxis;Child;Childhood;Childhood Asthma;Chronic Disease;Clinical;clinical biomarkers;Clinical Markers;cost;cytokine;Data;Decision Making;Disease;disease phenotype;Effectiveness;Emergency department visit;Enzymes;eosinophil;Exhalation;Exhibits;experience;Exposure to;Extrinsic asthma;Functional disorder;Generations;Genes;Genetic;Genetic Polymorphism;Genotype;Goals;Guidelines;Histamine;Histamine Receptor;Hypersensitivity;IgE;Immunologic Markers;Immunologics;immunoregulation;improved;Individual;Inhalation;innovation;Iontophoresis;Knowledge;Lasers;Leukotrienes;Link;Literature;Modeling;Monitor;Monoclonal Antibodies;Moods;Morbidity - disease rate;mortality risk;Mucous body substance;neutrophil;Nitric Oxide;novel;Nucleotides;omalizumab;Outcome;Pathway interactions;Patient Selection;Patients;pediatric patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;Phenotype;predicting response;Prediction of Response to Therapy;predictive marker;predictive modeling;Production;pulmonary function;Race;racial population;Regimen;Reproducibility;Research;response;Safety;side effect;Single Nucleotide Polymorphism;skin prick test;Steroids;success;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapy outcome;Treatment Efficacy;treatment response;United States;Weight Gain;Work

PROJECT_TITLE: A Histamine Pharmacodynamic Biomarker to Guide Treatment in Pediatric Asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Wound Healing and Care

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The epithelial lining of the gastrointestinal tract forms a regulated selective-permeable barrier and controls immune defense, which can be significantly compromised by conditions such as inflammatory bowel diseases, ischemia, mechanical injury and surgical procedures. Epithelial intercellular junctions play a pivotal role in barrier regulation. This proposal seeks to identify the molecular basis by which intercellular junction proteins control barrier function in health and disease, and will also identify how these proteins control repair after injury. Knowledge gained from these studies in the short term will provide a better understanding of basic mechanisms that control epithelial barrier function and wound healing, and in the long term, these studies will aid in the development of new therapeutic strategies aimed at strengthening the barrier and in promoting mucosal wound repair.

PI_NAMEs: NUSRAT, ASMA  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Acute;Address;Adherens Junction;Adhesives;beta catenin;Biological;Biopsy;Cell Line;Cell model;cell motility;Cells;Chronic;Colitis;Complex;cytokine;Data;desmoglein 2;Desmosomes;Development;Disease;Epithelial Cells;Epithelium;experimental study;Exposure to;Future;Gastrointestinal tract structure;Goals;gut inflammation;Health;Homeostasis;Human;Hypoxia;Immune;In Vitro;in vivo;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Bowel Diseases;Injury;insight;Integrins;Intercellular Junctions;intestinal epithelium;Intestinal Mucosa;Ischemia;knock-down;Knowledge;Leaky Gut;Leucocytic infiltrate;leukocyte mediator;Link;Mechanics;Mediating;Mediator;Membrane;migration;Modeling;Molecular;Monomeric GTP-Binding Proteins;Mucositis;Mucous Membrane;Mus;novel;novel therapeutic intervention;Operative Surgical Procedures;Pathogenesis;Permeability;Pharmaceutical Preparations;Physiological;Play;prevent;Process;Proliferating;Property;Proteins;Recovery;Regulation;repaired;response;response to injury;Role;Signal Transduction;Signaling Protein;Structure;targeted treatment;Therapeutic;therapeutic development;Therapeutic Intervention;Tight Junctions;vaccine delivery;wound;wound healing

PROJECT_TITLE: Regulation of intestinal epithelial barrier function by intercellular junction proteins in health and disease

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: TR

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PI_NAMEs: SCHLESINGER, SARAH JANE (contact)

PROGRAM_OFFICER_NAME: MERCHANT, CAROL

PROJECT_TERMS: Adherence;Bioinformatics;Biometry;career;Career Choice;career development;Clinical;clinical center;Clinical Research;Clinical Sciences;community engagement;Competence;Conceptions;Degree program;didactic education;Education;Electronic Health Record;empowerment;Epidemiology;experience;Feedback;Formulation;Goals;Grant;Health;Health Professional;Human;Humanities;improved;innovation;Institution;Instruction;Lead;Leadership;Master of Science;meetings;member;Mentors;Methods;Modeling;new technology;Ontology;Participant;Pharmacologic Substance;Phenotype;Physicians;Policies;Privatization;Production;programs;Protocols documentation;Reporting;Reproducibility;Research;Resources;responsible research conduct;Science;Scientist;Special Event;Training;Translational Research;translational scientist;Translations;United States National Academy of Sciences;Universities;Vision

PROJECT_TITLE: Institutional Career Development Core


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative  Foreign-born Latinos in the United States are at risk for poor health outcomes, including poor outcomes for cardiovascular disease. It is uncertain whether or not they receive fewer prevention services for cardiovascular conditions, and if so, which specific factors may be most responsible for the lower receipt of these services. This project will use a highly innovative electronic health record database that contains country of birth information and is linked to community information in order provide policy makers and healthcare providers better information about what cardiovascular prevention services their patients or community members are most at risk for underutilizing.

PI_NAMEs: HEINTZMAN, JOHN  (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Address;Aspirin;authority;barrier to care;Birth;Blood Pressure;Body mass index;Cardiovascular Diseases;Cardiovascular system;Caring;Categories;Clinical;Communities;Community Health Education;Community Health Networks;community-level factor;Country;Cuban;Data;Data Linkages;data resource;Data Set;Databases;Demographic Factors;Disparity;Education;Educational Status;Electronic Health Record;Ethnic Origin;Ethnic Population;ethnic segregation;experience;Fright;Geography;Glucose;Health;health care availability;health care service utilization;health data;Health Personnel;Health Services Research;Healthcare;Immigrant;Immigration;improved;Individual;Inequality;innovation;Insurance;Insurance Coverage;Intervention;Knowledge;Language;Latino;Latino Population;Link;Lipids;Literature;longitudinal dataset;Measurement;Measures;member;Methods;Mexican;Morbidity - disease rate;mortality;Neighborhood Health Center;Not Hispanic or Latino;Outcome;patient oriented;patient-level barriers;Patients;point of care;Policies;Policy Maker;poor communities;poor health outcome;Population;population based;population health;Population Intervention;Poverty;preference;Prevention;prevention service;Preventive service;Provider;Public Health;Race;Recommendation;Reporting;Research;Research Personnel;Resources;Risk;risk stratification;Rural;rurality;Sampling;screening;Screening for cancer;screening services;service utilization;Services;Smoker;social factors;social health determinants;Spanish;Subgroup;Tobacco;United States;urban residence;Vulnerable Populations

PROJECT_TITLE: FOCUS: Foreign Born Latinos Cardiovascular Screening

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

ORG_STATE: CA

PHR: Cannabis use and cannabis use disorder are increasing across the United States, and likely under-recognized among Veterans using VA primary care. This means that Veterans who would benefit from treatment and/or referral are not being identified. Cannabis is often perceived as harmless and marketed as helpful for a range of health conditions, despite a lack of evidence for these claims. Chronic health and mental health conditions that are common among Veterans, including depression, anxiety, posttraumatic stress disorder, and insomnia, are often reported as motivation for cannabis use. However, regular cannabis use may instead maintain or worsen these conditions and contribute to other health risks. This proposal will clarify relationships between patterns of cannabis use and physical and mental health outcomes, identify gaps in care, and assess the need for implementing screening for cannabis use in primary care.

PI_NAMEs: GIBSON, CAROLYN ;KEYHANI, SALOMEH  (contact)

PROJECT_TERMS: Accident and Emergency department;Address;Adult;adverse outcome;Age;aged;Alcohol consumption;Alcohols;Anxiety;Area;Behavior;Behavior Therapy;brief intervention;Cannabis;cannabis use behavior;cannabis withdrawal;Caring;Characteristics;Chronic;Cognitive Therapy;cohort;comorbidity;Confusion;Data;Drug Screening;Drug usage;effective therapy;Ensure;experience;Feeling suicidal;Foundations;Frequencies;Functional impairment;gabapentin;Health;high risk;Hospitalization;improved;Individual;innovation;Intervention;Interview;Malignant Neoplasms;Marijuana Smoking;marijuana use;marijuana use disorder;marijuana user;Marketing;Measures;Medical Records;Mental Depression;Mental Health;Methodology;middle age;military veteran;Monitor;Motivation;motivational enhancement therapy;Needs Assessment;opioid use;Outcome;Patients;Pattern;Pharmaceutical Preparations;physical conditioning;Polypharmacy;Population;Populations at Risk;Post-Traumatic Stress Disorders;Prevalence;Primary Care;primary care patient;primary care provider;primary care setting;prospective;Provider;psychologic;Psychoses;racial minority;Reporting;Respiratory Signs and Symptoms;Risk;Sampling;screening;sexual minority;Sleeplessness;Smoking;Subgroup;Substance Use Disorder;Symptoms;Telephone;telephone based;Tobacco;Tobacco use;Treatment outcome;treatment services;United States;Urine;Validation;Veterans;Women's Health

PROJECT_TITLE: Gaps in Identification, Referral and Treatment of Cannabis Use in VA Primary Care

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: ORLANCE, INC.

ORG_STATE: WA

PHR: Project Narrative The objective of this project is to continue development of a “universal” influenza vaccine that targets all A and B strain viruses. Such a vaccine is needed provide protection against all influenza A and B viruses to a substantial portion of the world’s population.

PI_NAMEs: BAGLEY, KENNETH C (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: Antibodies;Antibody Response;Antigen-Presenting Cells;Antigens;Body Weight decreased;Cells;Clinical;Clinical Trials;Companions;Data;design;Development;Devices;DNA;DNA delivery;DNA Vaccines;Dose;Electroporation;Engineering;Exhibits;experience;Ferrets;Formulation;gene gun;Gold;Human;Humoral Immunities;Immune;Immune response;immunogenicity;Immunologics;Inflammation;Inflammatory Response;Influenza;Influenza A virus;Influenza B Virus;influenza virus strain;influenzavirus;Injections;innovation;Liquid substance;Lung;Macaca;Macaca fascicularis;Macaca mulatta;Modeling;Mucosal Immune Responses;Mucous Membrane;Mus;next generation;nonhuman primate;novel;particle;Pathogenesis;Phase;Population;pre-clinical;Pre-Clinical Model;Preclinical Testing;Predisposition;protective efficacy;Publishing;Reagent;Reporting;response;Role;Safety;safety assessment;Site;Skin;Small Business Innovation Research Grant;Strategic Planning;Syringes;T cell response;T-Lymphocyte;Testing;Toxic effect;United States National Institutes of Health;universal influenza vaccine;unvaccinated;Vaccinated;Vaccination;Vaccine Antigen;vaccine delivery;vaccine development;vaccine evaluation;Vaccines;Viral;Viremia;Virus;Virus Replication

PROJECT_TITLE: Universal Influenza A/B Vaccine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-N(07)B]


ADMINISTERING_IC: DC

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition;Sleep Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PI_NAMEs: ROMAN ORTIZ, CIORANA  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;Affect;Animals;Behavior;Cognitive;Corpus striatum structure;density;dietary;Electroencephalography;Event;executive function;experimental study;extracellular;Extracellular Structure;Fire - disasters;Goals;Grant;Hippocampus;Impairment;improved;in vivo;insight;Knowledge;Learning;locus ceruleus structure;Medial;Mediating;Memory;memory acquisition;memory consolidation;memory recall;Metabolic;Modeling;motivated behavior;neural circuit;Neurons;non rapid eye movement;noradrenergic;novel therapeutics;optogenetics;Pathway interactions;Pattern;Pattern Recognition;Phase;Play;Prefrontal Cortex;Probability;Role;Sleep;sleep spindle;Slow-Wave Sleep;Structure;Task Performances;Taste Perception;tool;Training;trait;Update;Work

PROJECT_TITLE: Metabolic and Dietary Influences on Striatal Contributions to Taste-motivated Behavior


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Microbiome

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative  The human microbiome is shaped by numerous stressors. This project investigates how communities of bacteria change in response to complex and stress environments.

PI_NAMEs: JENSEN, PAUL ANTHONY (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TITLE: Microbial multi-stress responses: from intracellular networks to communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emergency Care;Health Services;Heart Disease;Hematology;Patient Safety;Prevention;Stroke

ORG_DEPT: EMERGENCY MEDICINE

PHR: Project Narrative/Relevance Atrial fibrillation is a common heart rhythm disorder, and it is responsible for up to 1.2 million Emergency Department (ED) visits per year, with an estimated cost of $6.65 billion per year in the United States. In appropriately selected patients per professional guidelines, oral anticoagulants (OACs) prevent strokes, yet clinicians rarely prescribe OACs during an ED visit, leading to delayed and fragmented care. By implementing a clinical decision support tool consistent with evidence-based guidelines and optimizing the tool through feedback from clinicians and patients, this research plan has the potential to improve both the transition of care for ED patients with AF and long-term clinical outcomes.

PI_NAMEs: KEA, BORY  (contact)

PROGRAM_OFFICER_NAME: EINHORN, PAULA T

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Address;Adult;Affect;American;Anticoagulants;Anticoagulation;Arrhythmia;Atrial Fibrillation;Atrial Flutter;Cardiovascular system;care fragmentation;Caring;Case Study;Cellular Phone;Cessation of life;Chronic;Client satisfaction;Clinic;Clinical;clinical decision support;clinical decision-making;Cluster randomized trial;comorbidity;computerized physician order entry;Computers;cost;cost estimate;Data;design;Development;Diagnosis;Disease;Electronic Health Record;Electronics;Emergency Care;Emergency Department evaluation;Emergency Department patient;Emergency Department Physician;Emergency department visit;emergency settings;empowerment;Environment;evidence based guidelines;experience;Feedback;Future;Goals;Guideline Adherence;Guidelines;Health;Health Care Costs;Health system;Healthcare Systems;Heart Diseases;Heart failure;heart rhythm;high risk;Hospitals;implementation tool;improved;Incentives;Individual;Intervention;Knowledge;longitudinal care;Manuals;Medicare;Methods;Mission;Monitor;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Online Systems;Oral;organizational readiness;Outcome;Outpatients;Patient Care;patient engagement;patient oriented;patient population;Patient Selection;Patient-Focused Outcomes;Patients;Pattern;payment;Pharmaceutical Preparations;Physicians;prevent;Prevention;Primary Care;primary outcome;Prophylactic treatment;Proxy;Recommendation;Research;Research Personnel;Resource-limited setting;Resources;Risk;Risk Reduction;Rural;Scientist;secondary outcome;shared decision making;Stroke;stroke patient;Stroke prevention;stroke risk;support tools;System;Testing;Time;tool;Training;trial design;United States;Update;Variant;Warfarin;web portal

PROJECT_TITLE: Optimizing Stroke Prophylaxis of Acute Atrial Fibrillation with an Electronic Clinical Decision Support Tool: A Stepped-Wedge Cluster Randomized Trial Design


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Genetics;Human Genome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE We will conduct new genetic assays of stored biospecimens from the Dutch Hunger Winter Families Study (DHWFS). This is needed to further examine the long-term impact of famine at the time of birth on the development of chronic disease in later life accounting for selective fertility and fetal mortality. Using the famine as a model, the study will significantly increase understanding of how perinatal insults affect health in aging, opening new avenues for intervention to prevent and reverse damage caused by perinatal insult. !

PI_NAMEs: BELSKY, DANIEL WALKER;LUMEY, L H (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: accelerated epigenetic aging;Accounting;Address;Adult;Affect;Age;age related chronic disease;age-related disease;Aging;aging related;aging related disease;Animal Experiments;Biological;Biological Aging;Biological Assay;Birth;Birth Rate;Blood;Blood specimen;Cardiometabolic Disease;cardiometabolism;Characteristics;Child;Chronic Disease;Clinical;Cognitive;cognitive reserve;cognitive testing;cohort;Conceptions;Data;Databases;Development;Disease;DNA Methylation;DNA Sequence;epigenetic aging;Epigenetic Process;Event;evidence base;experimental study;Exposure to;Family Study;Famines;Fertility;fetal;Fetal Growth Retardation;Fetal Mortality Statistics;follow-up;Future;Genetic;genetic analysis;genetic approach;genetic information;genetic selection;genetic testing;genetic variant;Genetic Variation;genome wide association study;genome-wide;Genomics;Genotype;Goals;Health;healthspan;Human;Hunger;improved;in utero;Individual;Infant;Intervention;Knowledge;knowledge base;late life;Life;Life Cycle Stages;Link;Long-Term Effects;Measures;Mediator;member;Methylation;Modeling;multiple omics;Natural experiment;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Obesity;Observational Study;Onset of illness;Outcome;Participant;Pathology;Pathway interactions;Perinatal;perinatal period;polygenic risk score;Population;prenatal;prevent;Prevention strategy;Process;public health priorities;Publishing;Quantitative Trait Loci;randomized trial;Research;Resources;Risk;Sampling Studies;Selection Bias;Siblings;study population;Survivors;Testing;Time;treatment strategy;unethical;War;whole genome;Work

PROJECT_TITLE: Genetic analysis of the Dutch Hunger Winter Families Study to Boost Rigor and Robustness for Testing In-Utero Famine Effects on Aging-Related Health Conditions and Biological Aging

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE As adults move into older age, they tend to acquire more chronic health conditions and disabilities such as hearing loss. To ensure that older adults with hearing loss live longer, healthier lives, research is needed to understand disparities in chronic health conditions and mortality and identify the factors that contribute to these differences. This research will provide evidence to inform initiatives and health promotion programs that will work towards improving the health of older adults with hearing loss.

PI_NAMEs: TAN, NASYA S (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Address;Adult;Affect;Age;aged;Aging;American;Area;Biological Markers;Black race;black women;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;Chronic;cohort;Communication;Cross-Sectional Studies;Data;Data Analyses;Decision Making;Diabetes Mellitus;Diagnosis;disability;Disease;Disparity;ethnic disparity;ethnic minority;Ethnic Origin;experience;Fellowship;Gender;Health;Health and Retirement Study;health difference;health disparity;Health Insurance;health literacy;Health Personnel;Health Promotion;Hearing;hearing impairment;hearing loss risk;high risk;Hispanic;human old age (65+);Hypertension;improved;Individual;Inequity;Interview;Knowledge;Life;Literature;low health literacy;low socioeconomic status;male;Measures;Mediating;Mental Health;Mentors;mortality;Myocardial Infarction;National Research Service Awards;Not Hispanic or Latino;Obesity;older adult;Outcome;Pathway interactions;peer;Persons;Physical assessment;physical conditioning;poor health outcome;Population;population based;pre-doctoral;prevent;Process;programs;psychological distress;Race;racial disparity;racial minority;Reporting;Research;Research Personnel;Risk;Sampling;Services;sex;skills;social determinants;Social Identification;sociodemographic factors;Subgroup;Surveys;Time;Training;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Social Determinants of Cardiovascular Health and Mortality among Older Adults with Hearing Loss

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Orphan Drug;Pain Research;Precision Medicine;Rare Diseases;Sickle Cell Disease

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Public Health Relevance Statement/Project Narrative Sickle cell disease affects millions of people worldwide, and is characterized by painful vaso-occlusive crises (VOC) that cause great morbidity and mortality. Although the main molecular mechanisms causing VOC are known, there are no ways to image them in humans, which hampers clinical research and care. We propose that positron emission tomography (PET) imaging targeting important molecules responsible for VOC will allow precision medicine approaches to transform clinical care, and new endpoints for clinical research of this disease that primarily affects underserved, minority populations in the US and elsewhere.

PI_NAMEs: ANDERSON, CAROLYN J.;NOVELLI, ENRICO M (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Acute;Acute Pain;Address;Adhesions;Adhesives;Adopted;Adverse reactions;Affect;Aftercare;alternative treatment;analog;Antibodies;Attenuated;bench to bedside;beta Globin;Binding;Biological Markers;biomarker driven;Blood;Blood Cells;Blood Vessels;bone;care providers;Cell Adhesion Molecules;Chronic;clinical care;Clinical Management;Clinical Research;Clinical Trials;cost;Dangerousness;Disease;drug development;Drug Targeting;Endothelial Cells;Endothelium;Erythrocytes;experimental study;FDA approved;Future;Genetic Diseases;Grant;Hemin;Hemoglobin;Hemoglobinopathies;Hemolysis;Histology;Human;human model;Human Pathology;Hypoxia;Image;imaging biomarker;in vivo;Inflammatory;inflammatory marker;Inherited;Institution;Institutional Review Boards;Integrin alpha4beta1;Integrins;Ischemia;Knowledge;Link;Lipopolysaccharides;Lung;Measurement;Measures;Mediating;Microfluidics;Minority Groups;Molecular;molecular imaging;Monitor;Monoclonal Antibodies;Morbidity - disease rate;mortality;multidisciplinary;Mus;Mutate;Mutation;Names;neutrophil;new therapeutic target;novel drug class;overexpression;Oxidative Stress;P-Selectin;Pain;Patient imaging;Patients;Persons;Pharmaceutical Preparations;Positron-Emission Tomography;precision medicine;prevent;Process;Prophylactic treatment;public health relevance;Recording of previous events;Research;Resort;response;Reticulocytes;Risk;Role;Safety;Scanning;Seminal;Sickle Cell Anemia;targeted imaging;Testing;Therapeutic;Time;Tracer;Transgenic Organisms;translational potential;Treatment Efficacy;treatment trial;two photon microscopy;Underserved Population;uptake;vaso-occlusive crisis;Visualization

PROJECT_TITLE: PET Imaging of Vaso-Occlussive Crisis in Sickle Cell Disease

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hypertension;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Hurricanes Irma and Maria in 2017 killed over 1000 people in the U.S. territories of Puerto Rico and the US Virgin Islands. One third of deaths after natural disasters have been attributed poorly managed chronic diseases such as diabetes and heart disease. This proposal will develop an emergency preparedness plan to reduce morbidity and mortality due to diabetes, hypertension, and heart failure after natural disasters in the U.S Virgin Islands and Puerto Rico.

PI_NAMEs: HASSAN, SARIA  (contact)

PROGRAM_OFFICER_NAME: MASTERSON, MARY YAA SEDEGAH

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Administrator;Adoption;Affect;burden of chronic illness;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cessation of life;Chronic Disease;Clinic;Clinical;Collaborations;Communication;Communities;Complex;Data;Data Analyses;design;Diabetes Mellitus;Diabetes prevention;Disaster Planning;Disasters;Disease;Disease Management;Disparity;disparity reduction;dynamic system;emergency preparedness;Emergency Situation;Evaluation;Evidence based intervention;experience;Federally Qualified Health Center;Foundations;Frequencies;Funding;Future;Goals;Health Planning Organizations;Healthcare Systems;Heart Diseases;Heart failure;Hurricane;Hypertension;implementation evaluation;implementation facilitators;implementation science;improved;Individual;informant;interest;Intervention;Interview;Knowledge;Lead;Location;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;Methods;Minority;Minority Groups;Modeling;models and simulation;Morbidity - disease rate;mortality;National Institute on Minority Health and Health Disparities;Natural Disasters;patient oriented;patient population;Patients;Pediatrics;Persons;Physicians;Pilot Projects;Policies;Population;Positioning Attribute;post implementation;preventive intervention;primary health center;Procedures;Provider;Puerto Rico;Readiness;Research;Research Methodology;Research Personnel;Research Project Grants;Risk Assessment;Role;Science;Seasons;Self Management;service providers;Services;simulation;Site;skills;socioeconomics;Surveys;System;Testing;Texas;Time;tool;Training;Underinsured;Underserved Population;Uninsured;United States;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;United States Virgin Islands;Vulnerable Populations;Work

PROJECT_TITLE: A Plan to Reduce Non-Communicable Disease-Related Morbidity and Mortality After Natural Disasters

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Complementary and Integrative Health;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Natural Products;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Cryptosporidium is a parasite found worldwide that causes diarrheal disease that can be severe and even fatal in AIDS patients. We have found a compound produced by a marine bacterium that kills Cryptosporidium in culture and in mice. The purpose of this work is to understand the properties and activity of this compound so it can be developed as a drug to treat this parasite.

PI_NAMEs: O'CONNOR, ROBERTA M (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Antiparasitic Agents;Area;asexual;Bacteria;Biological Availability;Cells;Cessation of life;Characteristics;Chronic;Clinical;Complex;Consumption;Cryptosporidiosis;Cryptosporidium;Cryptosporidium parvum;Data;design;Developed Countries;Developing Countries;Development;Diarrhea;diarrheal disease;Disease;Dose;Drug Kinetics;effective therapy;efficacy evaluation;Future;gastrointestinal;Growth;human disease;immune reconstitution;Immunocompromised Host;Immunosuppression;In Vitro;in vivo;Individual;Infant;Infection;innovation;Intestines;Invertebrates;Investigation;lead candidate;Length;Life Cycle Stages;Luciferases;marine;marine natural product;Medical;Mining;Modeling;mouse model;Mus;Natural product discovery;Natural Products;neglect;Neonatal;neonatal mice;nitazoxanide;Oocysts;optimal treatments;Organoids;Parasites;pathogen;Patients;Pharmaceutical Preparations;Pharmacodynamics;Predisposition;Process;Production;Property;Protocols documentation;Regimen;Reporting;Ruminants;Species Specificity;Specificity;Sporozoites;Structure;symbiont;Symptoms;Testing;Therapeutic;therapeutic candidate;therapeutically effective;Time;Toddler;Toxic effect;treatment optimization;treatment strategy;waterborne;waterborne outbreak;Wood material;Work

PROJECT_TITLE: Development of a new marine natural product for the treatment of cryptosporidiosis, an AIDS-defining disease

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Cancer Genomics;Genetics;Human Genome

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE Regulatory T cells (Tregs) are suppressors of the immune system that prevent autoimmune diseases and also dampen immune responses to tumors. The goal of this project is to define the role of the BAF (BRG1-associated factors) chromatin remodeling complex in Treg function. The proposed research will further enhance knowledge of the epigenetic mechanisms that control Treg cells, which can potentially lead to the development of novel Treg-targeting therapies for autoimmune disease and cancer.

PI_NAMEs: HARGREAVES, DIANA CLARE;ZHENG, YE  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: 3-Dimensional;Affect;anti-tumor immune response;Area;Autoimmune;Autoimmune Diseases;Autoimmunity;Binding;Binding Sites;Biochemical;Bioinformatics;Bromodomain;Cancer Model;Cell Lineage;Cell Physiology;Cells;Cellular biology;Chemicals;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Complex;conditional knockout;CRISPR/Cas technology;Development;disease model;Disease Progression;DNA;Drug usage;Epigenetic Process;Equilibrium;experimental study;Failure;FOXP3 gene;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Goals;Hi-C;Homeostasis;Human;Immune response;Immune system;immunopathology;Impairment;improved;in vivo;Inflammatory;inhibitor;insight;Insulin-Dependent Diabetes Mellitus;Knock-out;Knockout Mice;Knowledge;Lead;Link;loss of function mutation;Lymphoproliferative Disorders;Maintenance;Malignant Neoplasms;Melanoma;Modeling;mouse model;Multiple Sclerosis;Mus;novel;novel therapeutics;Ontology;Outcome;Outcomes Research;Play;prevent;Proteins;recruit;Regulation;Regulatory T-Lymphocyte;Repression;Research;Research Personnel;Rheumatoid Arthritis;Role;Screening Result;SMARCA4 gene;Suppressor-Effector T-Lymphocytes;System;T-Cell Development;targeted treatment;Testing;transcription factor;Transcriptional Regulation;transcriptome sequencing;tumor;tumor immunology

PROJECT_TITLE: The role of BAF related complexes in regulatory T cell development and function

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Biotechnology;Natural Products

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Microbes make a number of fascinating chemical compounds, highly interesting “natural products” that are the basis of many drugs. Thus, nature’s biosynthetic machinery is a potential target for engineering to develop new drugs or improve existing ones. These studies will discover the 3D structures and fundamental details about how enzymes catalyze some highly unusual reactions in natural product biosynthesis, thereby aiding drug discovery efforts and advancing fundamental enzymology.

PI_NAMEs: SMITH, JANET L. (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Acetyl Coenzyme A;Acetyltransferase;Active Sites;Amaze;amidation;Amides;Amino Acids;Anabolism;Antibiotics;Area;bioactive natural products;Bioinformatics;Biological Assay;biological systems;Biology;C-terminal;Carboxy-Lyases;Carboxylic Acids;Carrier Proteins;chemical group;chemical reaction;Chemicals;Chemistry;Coenzyme A;Complex;Data;Decarboxylation;design;Development;DNA Sequence Analysis;drug discovery;Engineering;Enzymatic Biochemistry;Enzymes;Erythromycin;Evolution;Family;Family member;fascinate;Flavins;Funding;genomic data;Homologous Gene;Hydroxylation;improved;Individual;Indole Alkaloids;insight;Investigation;Metabolism;Microbe;Mixed Function Oxygenases;Multienzyme Complexes;Natural Products;Nature;novel;novel therapeutics;Oxidoreductase;Pathway interactions;peptide synthase;Peptides;Pharmaceutical Preparations;polyketide synthase;polyketides;Proteins;Reaction;Reporting;secondary metabolite;Shapes;Siderophores;Site;Source;Specificity;structural biology;Structure;Substrate Interaction;System;Testing;Therapeutic;three dimensional structure;tool;Tropolone;unnatural amino acids

PROJECT_TITLE: Structural Biology of Complex Enzymes

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Alzheimer’s disease (AD) pathology is defined by aberrant protein aggregation within the brain, underscoring the importance of neuronal protein degradation and the autophagy-lysosomal system. Of particular interest are the selective autophagy proteins optineurin (OPTN) and BCL-2-associated athanogene 3 (BAG3), which appear to be relevant in the degradation of neuronal tau protein. Therefore, this proposal aims to further the understanding of tau protein degradation via autophagy and define the molecular mechanisms governing OPTN and BAG3 regulation and function in neurons, which may lead to novel therapeutic modalities.

PI_NAMEs: AUGUR, ZACHARY MARK (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Adaptor Signaling Protein;Address;Affect;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Amino Acids;Amyloid beta-Protein;Autophagocytosis;BAG3 gene;BCL1 Oncogene;Biological Assay;Bortezomib;Brain;Clinical;cohort;Compensation;CRISPR/Cas technology;Data;Dementia;excitatory neuron;Exposure to;extracellular;Genetic;Homeostasis;Human;hyperphosphorylated tau;Impaired cognition;Individual;Induced pluripotent stem cell derived neurons;interest;knock-down;Knock-out;Late Onset Alzheimer Disease;Mass Spectrum Analysis;Measures;Mediating;Memory;Modality;Molecular;Molecular Chaperones;multi-electrode arrays;multicatalytic endopeptidase complex;Nerve Degeneration;Neurofibrillary Tangles;Neurons;neuropathology;neurotoxic;new therapeutic target;novel therapeutics;Physiologic pulse;Physiological;Play;Predisposition;Proteasome Inhibitor;protein activation;protein aggregation;protein degradation;Proteins;Proteomics;proteostasis;Protocols documentation;Regulation;religious order study;Reporter;response;Risk;Role;Senile Plaques;small hairpin RNA;Stable Isotope Labeling;System;targeted treatment;tau aggregation;tau Proteins;tau-1;TBK1 gene;Ubiquitin;Western Blotting;Work

PROJECT_TITLE: Selective neuronal autophagy in phosphorylated tau degradation and Alzheimer's disease


ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: PROJECT NARRATIVE The hyperactivity of cell signaling pathways, such as the nuclear factor kappa B (NF-κB) pathway, facilitate cancer progression through the upregulation of cell survival and proliferative activities in numerous malignancies, including acute lymphoblastic leukemia (ALL). Recent reports have found that expression of the Cajal body marker protein coilin is elevated in ALL patients and that coilin positively regulates NF-κB signaling via coilin- mediated microRNA biogenesis. The investigations proposed here will uncover the molecular basis by which coilin is contributing to microRNA biogenesis and cancer progression via the NF-κB signaling pathway and will lay the groundwork for future studies involving therapeutic and biomarker development surrounding coilin- mediated cancer progression.

PI_NAMEs: MCLAURIN, DOUGLAS  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: 20 year old;Acute Lymphocytic Leukemia;Apoptotic;Binding;Biogenesis;biomarker development;cancer cell;Cause of Death;Cell Proliferation;Cell Survival;cell type;Cells;Child;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;Data;Development;Elements;Embryonic Induction;Engineering;fly;Future;Gene Expression;Hyperactivity;Incidence;Inhibition of Apoptosis;Investigation;knock-down;Knock-out;Laboratory Finding;Link;Malignant Neoplasms;Mediating;Mediator;Methyltransferase;Microprocessor;MicroRNAs;Modeling;Modification;Molecular;Mus;NF-kappa B;novel;Nuclear;Nucleoplasm;Pathway interactions;Patients;Phenotype;Plants;Post-Translational Protein Processing;Process;prognostic;Prognostic Factor;Proliferating;protein biomarkers;Proteins;Publishing;Reader;Regulation;Reporting;Ribonucleoproteins;RNA;RNA methylation;Role;Signal Pathway;Signal Transduction;Small Nuclear Ribonucleoproteins;Telomerase;Testing;Therapeutic;therapeutic development;therapy resistant;Transformed Cell Line;tumor progression;tumorigenesis;Untranslated RNA;Up-Regulation;Work;Zebrafish

PROJECT_TITLE: Coilin is a Mediator of m6A RNA Methylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: EAST LANSING

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Understanding how evolutionary forces shape genetic variation for quantitative traits is crucial for determining the prevalence of genetic disease in human populations, but we lack a comprehensive view of how genotype by environment interactions (GxE) contribute to the maintenance of variation. I will address this gap by developing new methods for determining the evolutionary forces shaping GxE and applying them to large genomic and phenotypic datasets. This work will reveal the contributions of local adaptation, variation in evolutionary constraint across environments, and negative selection in maintaining GxE across natural populations.

PI_NAMEs: JOSEPHS, EMILY  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TITLE: Determining the evolutionary forces shaping genotype-by-environment interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


NIH_SPENDING_CATS: Nutrition;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: This project will identify dietary components and how they act via signaling pathways to regulate cell proliferation and differentiation in the context of an intact animal. Due to the highly conserved nature of metabolic signaling, our studies will contribute to understanding of fundamental mechanisms that maintain proliferating pools of cells, with possible implications for human fertility, development, degenerative diseases, cancer, stem cell biology, and parasite biology.

PI_NAMEs: HUBBARD, E. JANE ALBERT (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Animals;Biological Models;Biology;Caenorhabditis elegans;cell behavior;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cells;Complex;Cues;Degenerative Disorder;Development;Diet;dietary;Dietary Component;Dietary Factors;dietary manipulation;Eating;Ensure;Escherichia coli;Fertility;Generations;genetic manipulation;Germ Cells;germline stem cells;Growth;Human;Impairment;in vivo;Insulin;Internet;Laboratories;Link;Maintenance;Malignant Neoplasms;Metabolic;Metabolism;Modeling;Nature;Nutrient;Nutritional;Organ;Organism;Parasites;Process;progenitor;Proliferating;response;Signal Pathway;Signal Transduction;stem;stem cell biology;stem cells;Tissues;Transforming Growth Factor beta

PROJECT_TITLE: Diet and Germline Progenitors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: CA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric;Pediatric Cancer;Physical Activity;Prevention;Rare Diseases

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Cardiovascular complications negatively affect the quality and quantity of life in cancer survivors. This project will explore the role that known cardiotoxic treatments have on cardiovascular complications and the role exercise may play in mitigating these late effects within a specific age group (those diagnosed between the ages of 15 and 20 years old) of cancer survivors. This award will support my development towards becoming an independent nurse scientist dedicated to understanding the effects of cardiotoxic treatments on adolescent and young adult cancer survivors.

PI_NAMEs: HOOVER, BECKY LEIGH (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: 20 year old;Address;Adolescent;Adolescent and Young Adult;Adult;Affect;Aftercare;Age;age group;age related;Alkylating Agents;Anthracycline;Award;Canada;cancer complication;Cancer Survivor;Cancer Survivorship;cancer therapy;cancer type;Cardiac;Cardiotoxicity;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;career;career development;Cessation of life;chemoradiation;chemotherapy;Chest;Child;Childhood Cancer Survivor Study;Childhood Cancer Treatment;clinical care;cohort;Combination Drug Therapy;Data;Data Analyses;Dedications;Development;Development Plans;Diabetes Mellitus;Diagnosis;Dyslipidemias;Event;Exercise;experience;Foundations;Funding;General Population;Goals;Health Promotion;Heart failure;Heart Valve Diseases;Hodgkin Disease;Hypertension;improved;Incidence;Individual;Intention;Intervention;Knowledge;Late Effects;Life;Malignant Childhood Neoplasm;Malignant Neoplasms;Metabolic;Methods;Monoclonal Antibodies;Morbidity - disease rate;mortality;mortality risk;Myocardial Infarction;Myocardial Ischemia;National Cancer Institute;Neck;Nurses;Obesity;Oncology Nurse;Patient Self-Report;Physical activity;Physical Fitness;Play;Population;Prospective, cohort study;quality of life for cancer survivors;Radiation;Reporting;Research;research and development;Research Personnel;Resources;Risk Factors;risk stratification;Role;Scientist;secondary analysis;Siblings;Site;skills;Stroke;Structure;Survivors;survivorship;Testing;Time;Topoisomerase Inhibitors;Training;Tyrosine Kinase Inhibitor;United States;Work;young adult

PROJECT_TITLE: Incidence and Time on Onset of Cardiovascular Risk Factors and Cardiovascular Disease in Adult Survivors of Adolescent and Young Adult Cancer and Association with Exercise


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE During influenza infection, regulation of anti-viral T cells is necessary to promote clearance of the virus and prevent injury of the lung. Dendritic cells activate anti-viral T cells, and both dendritic cells and T cells express a regulatory protein called Tim3. A better understanding of how Tim3 controls immune cells during influenza could lead to new treatments for this disease and other respiratory viruses.

PI_NAMEs: CHO, JOSALYN L (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute;Affect;Antigens;Attenuated;Blocking Antibodies;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Survival;cell type;Cells;Cessation of life;checkpoint receptors;cross immunity;Cross Presentation;Data;Dendritic Cells;Disease;Equilibrium;experimental study;Generations;genetic regulatory protein;Goals;Human;Immune;immune checkpoint;Immune response;Immunity;Immunoglobulins;immunopathology;immunoregulation;Impairment;improved outcome;Infection;Influenza;Influenza A virus;influenza infection;Ligands;Lung;lung injury;lymph nodes;Mediating;Memory;Morbidity - disease rate;mortality;mouse model;Mucins;Mus;neutralizing antibody;novel;novel therapeutics;Outcome;Pharmaceutical Preparations;Phase;Play;prevent;Primary Infection;Process;Qualifying;receptor;Regulation;Research;Respiratory Failure;respiratory virus;response;Role;Serotyping;Severities;Signal Pathway;Signal Transduction;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic target;tissue resident memory T cell;Tissues;tool;Viral;viral resistance;Viral Respiratory Tract Infection;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Regulation of the host immune response to influenza by the checkpoint receptor Tim3


NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: NIH R35 GM118121; DNA transposons and alternative pre-mRNA splicing. D. Rio – PI. PROJECT NARRATIVE DNA transposons and alternative pre-mRNA splicing. D. Rio – PI Mobile genetic elements or transposons are found in the genomes of all organisms and 50% of the human genome is made up of transposable elements with ~ 2.7% corresponding to DNA-based transposons. Alternative pre-mRNA splicing is a common mechanism for regulating gene expression in metazoans. The protein factors involved in controlling DNA transposition and patterns of alternative splicing are found in the human genome, so results obtained in this proposal will have direct relevance and application to human health.

PI_NAMEs: RIO, DONALD C (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 5' Splice Site;Affect;Alternative Splicing;Amyotrophic Lateral Sclerosis;Animals;Behavior;Binding;Binding Sites;Biological Markers;cell type;Cells;cofactor;Complex;Courtship;Cryoelectron Microscopy;Defect;Disease;DNA;DNA Binding Domain;DNA Transposable Elements;DNA Transposons;Drosophila genus;Elements;Exhibits;Family;Gene Expression;Gene Mutation;Genes;Genome;Genomics;Guanosine Triphosphate;Health;Human;human disease;human embryonic stem cell;Human Genome;insight;Introns;Link;male;Malignant Neoplasms;member;Mobile Genetic Elements;mRNA Precursor;Mus;mutant;N-terminal;Neurodegenerative Disorders;Neurons;Organism;Pathway interactions;Pattern;Play;Polyadenylation;premature;Primates;Process;Protein Isoforms;Protein Structure Initiative;Proteins;Proteomics;Reaction;RNA;RNA Binding;RNA Splicing;RNA-Binding Proteins;Rodent;Role;Somatic Mutation;Spliceosomes;Split Genes;Structure;Tissues;Transcriptional Silencer Elements;transcriptome;Transposase;U1 Small Nuclear Ribonucleoprotein;United States National Institutes of Health;Work;Xenopus;Zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Genetics;Hematology;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE  Elucidating mechanisms that regulate erythroid differentiation continues to unveil fundamental discoveries that inform erythroid biology, hematology and broader mechanistic, biological and pathological problems. As mechanistic defects generate ineffective erythropoiesis, e.g. in bone marrow failure syndromes, sickle cell disease and other congenital anemias, which can be resistant to erythropoiesis-stimulating therapeutic agents, new mechanistic knowledge will provide the logic to devise efficacious strategies and advance technology to manufacture blood products from stem cells. Our multi-omic studies utilizing genetically engineered cultured cells and primary mouse and human cells will develop new paradigms to explain how GATA factors govern intracellular small molecule ensembles that control genome function and create feedback loops to regulate GATA factor function, hemoglobin synthesis and erythroid differentiation.

PI_NAMEs: BRESNICK, EMERY H (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Abnormal Red Blood Cell;Adenosine;adenosine transporter;Amino Acids;Apoptosis;Apoptotic;BACH1 gene;beta Globin;Biological;Biology;blood product;Blood Vessels;bone marrow failure syndrome;Carrier Proteins;Cells;ceramide 1-phosphate;Ceramides;Chromatin;cohort;Complement;Complex;Congenital Anemia;Cultured Cells;Defect;Development;dihydroceramide desaturase;Dimensions;Disease;Down-Regulation;Elements;Enhancers;Ensure;Enzymes;Epigenetic Process;Erythroblasts;Erythrocytes;Erythroid;Erythroid Cells;erythroid differentiation;Erythropoiesis;Feedback;Foundations;GATA1 gene;Gene Expression;Genes;Genetic Engineering;Genetic Transcription;Genome;genome editing;genome-wide;Globin;Grant;Hematology;Hematopoiesis;Heme;heme biosynthesis;Hemoglobin;Human;Impairment;innovation;insight;Knowledge;Lead;Link;lipidomics;Lipids;Logic;loss of function;manufacture;Mediating;Metals;migration;Modeling;Molecular and Cellular Biology;multiple omics;Mus;Mutate;Natural regeneration;Pathologic;Pathology;Pathway interactions;prevent;Process;progenitor;Proliferating;Pyruvate Kinase;pyruvate kinase deficiency;Red Blood Cell Count;Regulation;Resistance;SAM Domain;Sickle Cell Anemia;Signal Transduction;Signaling Molecule;small molecule;solute;Sphingolipids;sphingosine 1-phosphate;stem cells;System;Technology;Tertiary Protein Structure;Testing;Therapeutic Agents;transcription factor;Transcriptional Regulation;translational potential;Work;zinc-binding protein

PROJECT_TITLE: Transcriptional Control of Hemoglobin Synthesis and Erythrocyte Development


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: DETROIT

ORG_DEPT: CHEMISTRY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: The Wayne State University (WSU) T34 program seeks to continue its successful training program in biomedical sciences, and is requesting support for 20 undergraduate students per year. Through a structured academic community, additional career development activities, and individualized mentoring, the outstanding, diverse trainees will cultivate highly sought-after skills leading to entrance into Ph.D. and M.D./Ph.D. programs and successful careers in the biomedical sciences.

PI_NAMEs: ALLEN, MATTHEW J (contact);PILE, LORI A

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: academic program;Academic skills;Automobile Driving;career;CCL7 gene;Cities;college;Communities;Coupled;design;Doctor of Medicine;Doctor of Philosophy;Education Projects;Educational process of instructing;experience;Faculty;Funding;Future;Future Generations;Goals;graduate school;graduate student;Growth;Institution;Knowledge;Learning;learning community;member;Mentors;Michigan;Mission;Modification;Population;Positioning Attribute;programs;recruit;Research;research and development;Science;skills;social culture;Structure;Students;success;Training;undergraduate student;Universities;Vision

PROJECT_TITLE: MARC at Wayne State University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: Narrative The proposed program will allow for higher speed and higher resolution operation of inertially limited optical scanners. The technology created in this program will be valuable to a wide range of applications which require high speed, high resolution, non-invasive imaging of tissue in vivo.

PI_NAMEs: XU, CHRIS  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Acceleration;Adoption;arbitrary spin;Brain;Brain imaging;data sharing;design;Devices;Dimensions;Frequencies;Goals;graduate student;Image;improved;in vivo;instrument;Laser Scanning Microscopy;Lasers;lens;Maps;Measurement;Methods;Microscope;multi-photon;multiphoton microscopy;Mus;Nature;Neurons;Neurophysiology - biologic function;Noise;non-invasive imaging;operation;optical imaging;Optical Methods;Optics;Penetration;Performance;Photons;Population;programs;Research;Resolution;response;Rotation;Sampling;Scanning;Shapes;Signal Transduction;Speed;System;Systems Integration;Technology;temporal measurement;Testing;Time;timeline;Tissue imaging;Tissues;Translating;two-photon;Width;Work

PROJECT_TITLE: Improving the Speed of Galvo-Scanners


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Drugs are designed to modulate the function of specific protein disease targets; however, there are currently no general methods for determining all off the unintended targets a drug may modulate leading to toxicity. In this project, we will develop a method designed to determine all the proteins to which a drug binds, which will enable chemists to develop compounds that engage the disease target with higher specificity. We will use this methodology to generate a new class of drug-like compounds that target an important class of cancer proteins; namely the histone deacetylases.

PI_NAMEs: YOUNG, DAMIAN WINSTON;YOUNG, NICOLAS L (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Acceleration;Amino Acids;Area;Bar Codes;Basic Science;Binding;Biochemical Pathway;Biological;blind;candidate selection;Catalogs;Cell Line;Cells;Chemicals;Chromatin;Clinical;clinical application;Collection;combinatorial;Data Analyses;Defect;design;Detection;Development;Disease;drug candidate;Drug Design;drug development;drug discovery;Drug Targeting;drug-like compound;Elements;enantiomer;Enzymes;Frustration;Generations;high throughput screening;Histone Acetylation;Histone Deacetylase;Histone Deacetylase Inhibitor;in vivo;inhibitor;innovation;Isotopes;Libraries;Life;Ligation;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Metabolic;Methodology;Methods;Molecular Mechanisms of Action;Neutrons;novel;novel drug class;Nuclear;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacology;Photoaffinity Labels;Physiological;Piperazines;Process;Proteins;Proteome;Reaction;Reagent;Regulation;Resistance;Resolution;Sampling;scaffold;side effect;Site;small molecule;small molecule inhibitor;Specificity;Statistical Data Interpretation;Structure;success;Support Groups;System;Systems Analysis;Technology;Testing;Toxic effect;Treatment Efficacy;Work

PROJECT_TITLE: Neutron encoded activity based probes

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: The power of genetics to define gene function, to pinpoint the roles of proteins and their individual amino acids, and to predict susceptibility to disease lies at the heart of modern biomedical science. The training offered by our program prepares young scientists to take full advantage of genetic approaches to solve difficult, but important problems in biomedical science and human disease.

PI_NAMEs: CAMILLI, ANDREW  (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Cell Physiology;Molecular Genetics

PROJECT_TITLE: Molecular Genetics of Basic Cell Function

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hearing Loss;Human Genome;Pediatric

ORG_CITY: CORAL GABLES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Program Director/Principal Investigator (Last, First, Middle): Project Narrative The goals of the proposal are to identify novel genetic causes of autosomal recessive non-syndromic deafness in a large repository of families and confirm their causative roles in extensive functional studies. Identified mutations along with their associated audio-vestibular findings will be stored in an online database to facilitate further studies. The outcome of this proposal will expand the scientific knowledge on the genomic basis of deafness, provide better molecular diagnostic tools to the affected families, and identify potential treatment targets for hearing loss. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page

PI_NAMEs: TEKIN, MUSTAFA  (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Affect;analysis pipeline;autosomal recessive trait;autosome;Bioinformatics;Biological;Birth;Candidate Disease Gene;candidate identification;candidate validation;causal variant;Cell Physiology;Cells;Child;Chromatin;Chromosome 8;Clinic;Clinical Data;Clinical Management;clinical translation;clinically significant;Cochlea;Code;Consanguinity;Counseling;CRISPR interference;CRISPR/Cas technology;Data;Databases;deaf;deafness;Diagnosis;diagnostic tool;DNA;empowerment;Enhancers;Etiology;Exclusion;exome sequencing;experimental study;Family;Foundations;FRAP1 gene;Functional disorder;gene discovery;Gene Expression;gene therapy;Genes;Genetic;Genetic Counseling;genetic deafness;genetic testing;Genetic Transcription;genetic variant;genome analysis;genome sequencing;Genomics;Goals;growth differentiation factor 6;hearing impairment;Hearing Tests;Human;Human Cell Line;improved;In Vitro;in vitro Model;Inbreeding;Individual;Infant;Integral Membrane Protein;International;Knock-in Mouse;Knock-out;Knowledge;Link;loss of function;Mediating;member;Modeling;Molecular;Molecular Diagnosis;Molecular Diagnostic Testing;molecular diagnostics;Morphology;mouse genome;mouse model;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Newborn Infant;normal hearing;notch protein;novel;Nucleic Acid Regulatory Sequences;Outcome;Parents;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Population;precursor cell;Principal Investigator;programs;progressive hearing loss;Regulatory Element;repository;reproductive;Research Personnel;Role;Sampling;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Site;standard of care;success;Testing;Therapeutic;Therapeutic Intervention;Time;Translating;Universities;Untranslated RNA;Variant;variant detection

PROJECT_TITLE: A Collaborative Search for New Genes for Non-Syndromic Deafness

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: MERCED

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, MERCED

PHR: PROJECT NARRATIVE In the dynamic cellular environment, high concentrations of small molecules and ions can change rapidly and dramatically over time and in different locations in the cell, but how proteins function in this shifting environment is poorly understood. For disordered proteins, which play major roles in diseases including cancer, Parkinson’s, and Alzheimer’s, such changes in the chemical makeup of the cell can have a major impact on activity and pathology. We propose to study how the cellular environment affects disordered proteins, linking their function to changes in the cell’s chemical composition.

PI_NAMEs: SUKENIK, SHAHAR  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Affect;Alzheimer's Disease;Area;Binding Proteins;Biochemistry;Biology;biophysical techniques;Buffers;Cell Cycle;cell growth regulation;Cell Physiology;Cells;Chemicals;Complex;design;Disease;disorder control;driving force;Ecosystem;Environment;Evolution;experimental study;Goals;Human;Ions;Link;live cell microscopy;Location;Malignant Neoplasms;Molecular;Molecular Conformation;Organism;Parkinson Disease;Pathology;Pathway interactions;Physical Chemistry;Play;Predisposition;protein function;protein structure;Proteins;Proteome;Regulation;Research Personnel;Role;sensor;simulation;small molecule;Structure;Surface;Testing;Time;tool;Tube;Work

PROJECT_TITLE: The Cellular Environment as a Regulator of Intrinsically Disordered Proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: DALLAS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Determinants of cell state reprogramming PROJECT NARRATIVE The proposed research is relevant to public health because understanding the molecular and cellular drivers of cell state is ultimately expected to advance the capability to engineer specific cell types for regenerative medicine. The project is relevant to the part of NIH's mission to accelerate basic biomedical research that increases our understanding of biological processes and lays the foundation for advances to ultimately improve human health.

PI_NAMEs: HON, GARY CHUNG (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Acceleration;Address;Biological Process;Biomedical Research;catalyst;Cell Differentiation process;Cell Reprogramming;cell type;Cells;Couples;Dimensions;Engineering;Epigenetic Process;epigenome;experimental study;Failure;Foundations;Genetic;Germ Cells;Goals;Health;Human;improved;Individual;innovation;insight;Knowledge;Learning;Mission;Molecular;Phenotype;Process;programs;Public Health;Regenerative Medicine;Research;success;transcription factor;transcriptome;United States National Institutes of Health

PROJECT_TITLE: Determinants of Cell State Reprogramming

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE  If we want to unlock the potential of personalized medicine, we first need to understand the impacts of each of the millions of protein sequence variants that exist in the human population. We will create a set of recombinant DNA technologies capable of simultaneously testing thousands of protein variants per experiment while also being generalizable enough to be easily applied to study a wide range of disease- relevant proteins. These biotechnologies will be made freely available to other researchers, and the data we generate during the development will reveal how changes to cancer-related genes promote oncogenesis, and how cancer-driving genes evolve resistance to different approved therapeutics.

PI_NAMEs: MATREYEK, KENNETH A (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Adoption;Amino Acid Sequence;Automobile Driving;Bacteriophages;Bar Codes;Biological;Biological Assay;Biological Models;Biology;Biotechnology;Cell Physiology;Cells;Clinical Data;Code;Collection;complement system;Complex;cost;Data;Development;Disease;DNA;Essential Genes;exome;Experimental Genetics;experimental study;Genes;Genetic;Genetic Engineering;Genetic Transcription;Genotype;Goals;Health;High-Throughput Nucleotide Sequencing;Human;improved;Individual;infancy;interest;Libraries;loss of function;Malignant Neoplasms;Methods;Modification;Molecular;overexpression;personalized medicine;Persons;Phenotype;Play;Population;Process;Proteins;Proteome;recombinase;Reporter;Research;Research Personnel;Resistance;Role;Signal Pathway;synthetic biology;System;Techniques;Technology;Testing;Therapeutic;tool;tumorigenesis;usability;user-friendly;Variant

PROJECT_TITLE: Recombinant DNA technologies for multiplex genetic assays in human cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Teenage Pregnancy;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Adolescent girls and young women in sub-Saharan Africa have the highest rate of undesired pregnancies and HIV incidence (relative to other ages) but little is known about the dynamics of contraceptive use and of HIV-prevention behaviors among this vulnerable age group because face-to-face data collection (the predominate data collection approach in sub-Saharan Africa) is too expensive and time-consuming to collect repeated measures. Therefore, the impact of changing states (income, schooling, residential mobility) on contraceptive use and pregnancy desire, as well as how HIV risk perception changes contraceptive behaviors is understudied. Using cell phones to collect high frequency, longitudinal data is an innovative approach that will lead to new insights about the circumstances surrounding adolescent girls and young women’s sexual and reproductive health, creating actionable data for increased reproductive autonomy.

PI_NAMEs: GREENLEAF, ABIGAIL REGAN (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;Adolescence;Adoption;Adult;Africa South of the Sahara;Age;age group;AIDS prevention;Area;Barbering;Behavior;career;career development;Cellular Phone;child bearing;condoms;Consent;Consumption;Contraception Behavior;Contraceptive Agents;Contraceptive Method Switching;Contraceptive methods;Contraceptive Usage;cost;Data;Data Collection;design;Development;Enrollment;Epidemiology;experience;Family health status;Female Adolescents;follow-up;Fostering;Frequencies;Funding;Future;global health;Goals;Health behavior;Health behavior change;health belief;HIV;HIV Infections;HIV risk;Hybrids;improved;Incidence;Income;Indiana;Infectious Pregnancy Complications;Injectable;innovation;insight;International;Interview;Knowledge;Learning;Logistic Regressions;Marriage;Measures;Mentored Research Scientist Development Award;Mentors;Methods;Modeling;Modernization;National Institute of Child Health and Human Development;novel;Outcome;Ownership;Participant;Pattern;Pediatrics;Perception;Persons;Planned Pregnancy;Planning Theory;Play;Population;Population Dynamics;population health;Population Study;Positioning Attribute;pre-exposure prophylaxis;Pregnancy;Prevalence;Prevention;Probability;professor;protective behavior;Puberty;rapid growth;reproductive;Reproductive Health;reproductive health intervention;Research;Research Activity;Research Personnel;Research Project Grants;Residential Mobility;Resources;response;Risk;risk perception;Sampling;Scholarship;Schools;Sex Behavior;sexual and reproductive health;sexually active adolescent;Shapes;skills;Sociology;Southern Africa;Statistical Methods;STI prevention;Surveys;Swaziland;Telephone;Testing;theories;Time;Training;training project;unintended pregnancy;United States National Institutes of Health;Universities;Woman;Work;young woman

PROJECT_TITLE: DYnamics of Contraception in Eswatini (DYCE)

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


PHR: Project narrative Induction of specific retrotransposon families have been observed during preimplantation development of multiple mammalian species, generating numerous retrotransposon derived promoters that drive alternative, preimplantation specific gene isoforms. Using mouse genetics, next generation sequencing, cell and molecular biology, our proposed studies will comprehensively categorize retrotransposon-dependent gene regulation, functionally characterize specific retrotransposon in essential developmental processes, and elucidate the importance of retrotransposon in gene regulatory diversity among different mammals.

PI_NAMEs: HE, LIN  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: 5' Untranslated Regions;Amino Acid Sequence;Atlases;Automobile Driving;Bioinformatics;Biological Process;blastocyst;Callithrix;Catalogs;Categories;Cattle;Cell Proliferation;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;comparative genomics;CRISPR/Cas technology;Data;Development;Developmental Process;Didelphidae;Economics;Elements;Embryo;Event;Evolution;Exons;Family;Family suidae;gene conservation;Gene Expression;Gene Expression Regulation;Gene Structure;Genes;Genome;genome editing;Genome engineering;Goat;Human;Impairment;implantation;in vivo;Livestock;Macaca mulatta;mammalian genome;Mammals;Mediating;Molecular;Molecular Biology;mouse genetics;mouse genome;Mus;mutant;N-terminal;next generation sequencing;Open Reading Frames;Phenotype;Physiology;Play;Polyadenylation;Pre-implantation Embryo Development;preimplantation;Primates;promoter;Protein Isoforms;Proteins;Publishing;Regulation;Repression;Retrotransposon;RNA;Role;Signal Transduction;single-cell RNA sequencing;System;Technology;Time;Transcript;Transcriptional Regulation;transcriptome sequencing;Validation

PROJECT_TITLE: Retrotransposon derived promoters drive alternative host gene isoforms with important developmental functions

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Streptococcus pyogenes, also known as group A streptococcus (GAS), is an exclusive human pathogen that causes an estimated ~ 600 million cases of strep throat and 500,000 cases of invasive disease-related deaths worldwide. The proposed research is significant and relevant to NIH mission because it is expected to elucidate the molecular details of bacterial communication that contributes to disease pathogenesis and identify novel therapeutic strategies to combat GAS infections.

PI_NAMEs: KUMARASWAMI, MUTHIAH  (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Anabolism;Animals;antagonist;Anti-Bacterial Agents;Antibiotics;antimicrobial;arms race;Bacteria;Bacterial Infections;Biochemical;Biological;Caspase;Cell Physiology;Cessation of life;Chemicals;colonization resistance;combat;commensal bacteria;commensal microbes;Communication;Complex;Conflict (Psychology);Cues;Cytosol;cytotoxicity;Data;delivery vehicle;Development;Disease;disorder control;Engineered Probiotics;Environment;extracellular;Funding;Future;Gene Cluster;Genetic;Growth;Health;Host Defense;Human;human pathogen;Image;Immune system;In Vitro;in vivo;Infection;interdisciplinary approach;interspecies communication;Invaded;Investigation;Knowledge;Left;Mediating;Membrane;Methodology;microbial community;microbiota;Mission;Molecular;mouse model;novel;novel therapeutic intervention;Oral cavity;oral commensal;Oropharyngeal;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Peptide Hydrolases;Peptide Signal Sequences;peptide synthase;Peptides;Pharyngeal structure;Physiological;polyketides;Population;Population Density;prevent;Process;Production;programs;Property;quorum sensing;receptor;Regulation;Research;resistance mechanism;Saliva;scaffold;secondary metabolite;Signal Pathway;Signal Transduction;Site;spatiotemporal;Streptococcal Infections;Streptococcus;Streptococcus pyogenes;Streptococcus salivarius;translational approach;United States National Institutes of Health;Vesicle;Virulence;Virulence Factors

PROJECT_TITLE: Molecular Mechanism of Virulence Regulation in Streptococcus Pyogenes

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE Mitochondria are the major energy producing organelles in eukaryotic cells and their dysfunction is implicated in many human diseases. AAA+ proteases help maintain mitochondrial activity by removing damaged and/or unneeded protein components in a timely fashion. This grant seeks to investigate how AAA+ proteases select and destroy specific mitochondrial proteins to shed light on the molecular basis of related human diseases.

PI_NAMEs: GLYNN, STEVEN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Active Sites;Address;Affinity;Apoptosis;Apoptotic;Architecture;ATP Hydrolysis;ATP phosphohydrolase;Automobile Driving;Binding;Binding Sites;Biochemical;Biological Assay;Catalytic Domain;Cell Physiology;Cells;Collection;Complex;crosslink;Crowding;Dangerousness;Development;Environment;Enzymes;Equilibrium;Eukaryotic Cell;Event;experimental study;Family;Fluorescence Polarization;Functional disorder;Future;Genome;Goals;Grant;Human;human disease;in vivo;in vivo monitoring;Individual;Inner mitochondrial membrane;Kinetics;Knowledge;Link;Maps;Mass Spectrum Analysis;Measures;Membrane;Metabolic;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;Molecular Chaperones;Mutation;Mutation Analysis;Names;Neurodegenerative Disorders;OPA1 gene;Organelles;oxidative damage;Oxidative Phosphorylation;Peptide Fragments;Peptide Hydrolases;Peptide Signal Sequences;Peptides;Phospholipid Metabolism;Physiological;preference;protein degradation;Protein Engineering;Protein Isoforms;Proteins;Proteolysis;Proteome;proteostasis;Quality Control;Reactive Oxygen Species;Regulation;Regulation of Proteolysis;Role;Series;Set protein;Side;Signal Transduction;Site;small molecule;Specificity;Spinocerebellar Ataxias;Structure;Surface;System;Therapeutic;Transmembrane Domain;Yeasts

PROJECT_TITLE: Using rebuilt AAA+ enzymes to uncover the mechanisms of proteolysis at the mitochondrial inner membrane


ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: The goal of this proposal is to understand how cells repair one type of DNA lesion, the double strand break (DSB). DSB repair is essential for a broad range of cellular processes from DNA replication to innate immunity, while dysregulated DNA repair is a hallmark of cancer and other human diseases. Research described in this proposal will increase our understanding of a fundamental biological process and may improve gene editing and chemotherapy.

PI_NAMEs: RICHARDSON, CHRIS  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Aging;Biological Process;Categories;Cell Cycle;Cell Death;cell injury;Cell Physiology;Cells;chemotherapy;Chromatin;Communication;Development;Diagnosis;DNA;DNA Binding;DNA biosynthesis;DNA Double Strand Break;DNA lesion;DNA Repair;Double Strand Break Repair;dynamic system;Event;Excision;falls;Generations;Genes;Genomic Instability;Genomics;Goals;Human;human disease;human DNA;improved;Malignant Neoplasms;Measures;Metabolism;Modeling;Natural Immunity;Outcome;Pathology;Pathway interactions;preservation;Process;protein complex;Proteins;Proteomics;Reagent;Repair Complex;repaired;Research;Resolution;Signal Transduction;Techniques;Therapeutic;Time;tool;Work

PROJECT_TITLE: Defining DNA resection and protein localization changes that occur during DSB repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Human reproductive health can be compromised both genetically or by exposure to myriad compounds found in prescription drugs, food containers and toxic waste products found in the environment. This work is significant because it will identify genetic and biochemical pathways that may be direct targets of these insults during gametogenesis. A detailed understanding of these pathways will aid in identifying the underlying causes of human infertility, birth defects and pregnancy loss by exposure to environmental contaminants.

PI_NAMEs: BURGESS, SEAN M (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3-Dimensional;Address;Aneuploidy;Behavior;Biochemical Pathway;Biology;biophysical properties;Cell Nucleus;Cells;Chromosome abnormality;Chromosome Pairing;Chromosome Structures;Chromosomes;Congenital Abnormality;Data Set;Diffusion;Drug Prescriptions;Ensure;Environment;Environmental Pollutants;epigenetic marker;Equilibrium;Event;Exposure to;Female;Food Container;Gametogenesis;Genetic;Genetic Recombination;Germ Cells;Goals;Homologous Gene;homologous recombination;Human;Image;Infertility;insight;Lead;lens;male;Meiosis;Meiotic Prophase I;model organism;Modeling;Molecular;Motion;Motor;Movement;Nuclear;Nuclear Envelope;Nuclear Pore Complex;Organism;Outcome;Pathway interactions;Polymers;Positioning Attribute;Pregnancy loss;Process;Prophase;reproductive;Reproductive Health;response;Role;Saccharomycetales;sex;Spermatogenesis;Spontaneous abortion;Synapses;telomere;Testing;Time;time use;Waste Products;Work;Yeasts;Zebrafish

PROJECT_TITLE: Homolog pairing in meiosis

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This NIA K76 Beeson Career Development Award resubmission application seeks to develop an electronic health record (EHR) measure (“eMeasure”) of low-value proton pump inhibitor (PPI) prescriptions among older adults, which would represent a timely and potentially transformative innovation in the quality of care field. The proposal also aims to design, pilot test, and implement an intervention consisting of a behavioral economic EHR-based clinical decision support tool to reduce low-value PPI prescriptions among older adults, informing a future NIA R01 application for a multisite pragmatic trial. The long-term goal of the project is to develop state- of-art and scalable methods to utilize the EHR to measure and reduce harmful, low-value care among older Americans.

PI_NAMEs: MAFI, JOHN  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;Adoption;Advanced Development;Aging;aging related;American;Appointment;Award;behavior change;behavioral economics;career;career development;Caring;Categories;Classification;Clinic;Clinical;Clinical Data;clinical decision support;Collaborations;Consensus;Country;Data;Delirium;design;Development;digital;Elderly;Electronic Health Record;electronic structure;evidence base;Funding;Future;Gastroenterologist;General Practices;Geriatrics;Goals;Health;Health Services Research;Health system;Healthcare;Human;human old age (65+);improved;inclusion criteria;inhibitor;inhibitor therapy;innovation;Insurance Carriers;Internal Medicine;Intervention;Intervention Trial;Interview;K-Series Research Career Programs;Knowledge;Lead;Leadership;Learning;Measurement;Measures;Medical;Medical Informatics;Medicare;Mentors;Methods;Modeling;older adult;Paper;Patient Care;Patients;Pharmaceutical Preparations;Pharmacists;Phase;Physicians;pilot test;point of care;Policy Maker;Polypharmacy;Population;pragmatic randomized trial;pragmatic trial;Primary Care;Principal Investigator;professor;Proton Pump Inhibitors;prototype;Publishing;Pump;Quality of Care;Research;Scientist;Secure;Sensitivity and Specificity;Series;Site;skill acquisition;skills;Specific qualifier value;Subgroup;support tools;Testing;therapy design;Time;tool;Training;Uncertainty;United States;United States Agency for Healthcare Research and Quality;Universities;Validity and Reliability;virtual;Work

PROJECT_TITLE: Leveraging Electronic Health Records to Measure and Reduce Harmful, Low-Value Care Among Older Adults


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: NARRATIVE Research in high income countries demonstrates the neurotoxicity of ambient and household air pollution on brain development, yet data are lacking from sub-Saharan Africa (SSA) where exposure magnitudes are among the highest worldwide. We develop a prospective cohort and capacity building to understand early life exposure sources and impacts on child healthy neurodevelopment in Nairobi. We leverage a foundation of linkages between the University of Washington and academic and governmental stakeholders in Kenya to establish a sustained program to inform future clinical trials, screening tools, program and policy.

PI_NAMEs: BENKI-NUGENT, SARAH F. (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 3 year old;Africa South of the Sahara;Age;air monitoring;Air Pollutants;Air Pollution;ambient air pollution;Ancillary Study;Animal Model;Aromatic Polycyclic Hydrocarbons;Attention deficit hyperactivity disorder;Attentional deficit;autism spectrum disorder;Award;biobank;Biological Assay;Biological Markers;biological specimen archives;Brain;Carbon Black;Characteristics;Child;Child Development;Child Health;Childhood;Clinical Trials;cofactor;Cognition;Cognitive;cognitive performance;cohort;Communication;Conceptions;cooking;Country;Data;design;Development;Disease;Disparity;early childhood;early life exposure;Educational workshop;Environmental Health;Environmental Risk Factor;epidemiology study;Evaluation;executive function;experience;Experimental Models;Exposure to;Faculty;fine particles;follow-up;Fostering;Foundations;Future;Goals;Government;Health;Household;Household Air Pollution;Hybrids;Impulsive Behavior;Income;Industrialization;Industry;infancy;Infant;Informal Social Control;innovation;Institution;Intellectual functioning disability;Intervention;Kenya;Laboratories;Language;Life;life span;Link;low income country;Maternal and Child Health;Measurement;Measures;Methods;Modeling;Monitor;mortality;Mothers;Motor;Motor Skills;neurodevelopment;neurotoxic;neurotoxicity;Neurotoxins;novel;Observational epidemiology;Outcome;Particulate Matter;Performance;Pilot Projects;Placenta;Policies;Policy Maker;Policy Making;pollutant;Pollution;postnatal;Pregnancy;prenatal;Private Sector;Process;Productivity;Program Sustainability;programs;prospective;Prospective cohort;Prospective Studies;repetitive behavior;Research;research to practice;Resource-limited setting;Science;Scientist;Screening procedure;skills;Source;student mentoring;Students;Technical Expertise;Third Pregnancy Trimester;Time;Tissues;ultrafine particle;Universities;urinary;Washington;Work

PROJECT_TITLE: Air Pollution Exposures in Early Life and Brain Development in Children


NIH_SPENDING_CATS: Digestive Diseases;Digestive Diseases - (Gallbladder);Liver Disease

ORG_CITY: BURLINGTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Project Narrative  Gallstone disease is one of the most common and most expensive of the digestive diseases in the USA. A major, but poorly understood, contributor to this disease is decreased function of the gallbladder muscle cells that are responsible for gallbladder function. This research will elucidate the mechanisms for decreased muscle function in gallbladder disease, and identify novel approaches to prevent and reverse gallbladder disease.

PI_NAMEs: LAVOIE, BRIGITTE  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Address;Agonist;AKT Signaling Pathway;Animal Model;Animals;Anti-Inflammatory Agents;Applications Grants;Bile fluid;bile salts;Cholecystectomy;Cholecystitis;Cholelithiasis;Cholestasis;Cholesterol;Controlled Environment;cost;Coupling;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclooxygenase Inhibitors;Data;Development;Diet;Digestive System Disorders;Disease;Disease Progression;Evaluation;Event;Experimental Models;experimental study;Foundations;Functional disorder;Gall Bladder Diseases;Gallbladder;Gallbladder Emptying;gallstone disease;high risk;high risk population;Human;hydrophilicity;Hydrophobicity;Image;Impairment;In Vitro;in vivo Model;Individual;Inflammation;insight;Interstitial Cell of Cajal;Knowledge;Lead;Measurement;Mediating;Modeling;Morbidity - disease rate;Motility;motility disorder;Motor;Mus;Muscle;Muscle Cells;Muscle function;novel strategies;optogenetics;Pacemakers;patch clamp;Pathway interactions;Periodicity;PIK3CG gene;Play;Positioning Attribute;Preparation;prevent;Property;protective effect;Research;response;Rest;Role;Signal Transduction;single molecule;Smooth Muscle;Smooth Muscle Myocytes;Sodium Chloride;T-Lymphocyte;Techniques;Testing;Therapeutic;Tissues;Transgenic Mice;Triglycerides;Ursodeoxycholic Acid

PROJECT_TITLE: Mechanisms of gallbladder smooth muscle dysfunction

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Alzheimer’s disease and associated dementias are major public health challenges with a multifold increase expected in the coming decades. This study will develop an advanced deep learning MR analysis technique to better classify and predict the manifestation of Alzheimer’s dementia. The project has considerable potential to immediately address multiple key knowledge gaps in disease etiology and how it manifests in minority ethnic groups.

PI_NAMEs: LIU, ZHONGMING ;PELTIER, SCOTT JAMES (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: 3-Dimensional;Address;African American population;Aging;Alzheimer's Disease;Back;base;Behavior;behavior measurement;behavior prediction;Behavioral;Biological Markers;Brain;brain volume;caucasian American;Classification;clinical application;clinical predictors;Cognitive;cohort;Complement;connectome;Data;Data Reporting;Data Set;deep learning;deep learning model;Dementia;design;Disease;ethnic minority population;Etiology;Evaluation;Functional Magnetic Resonance Imaging;Funding;Goals;Human;human data;Image;Impaired cognition;improved;individual response;Knowledge;Learning;Location;Longitudinal cohort;Measures;Michigan;mild cognitive impairment;Modeling;neuroimaging;Neurologic;Neuropsychology;Not Hispanic or Latino;older adult;open data;Pathology;Pattern;Phenotype;Prevalence;Public Health;reconstruction;Research;Rest;Sampling Studies;Source;Stress Tests;System;Techniques;Time;Training;Work;young adult

PROJECT_TITLE: Deep learning for prediction of Mild Cognitive Impairment and Dementia of the Alzheimer's type

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: College Station

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

PHR: PROJECT NARRATIVE The Food and Drug Administration (FDA) Veterinary Laboratory Investigation Response Network (Vet-LIRN) Veterinary Diagnostic Laboratory Cooperative Agreement Program is designed to promote human and animal health by providing scientific information and building laboratory capacity for routine and emergency response for investigation of outbreaks and to investigate problems with animal feeds and drugs. Detection of outbreaks requires the ability to collect samples from geographically diverse areas. The objective of this proposal is to provide additional infrastructure in Texas to support collection and testing of samples from pets to support the FDA Vet-LIRN mission of protecting human and animal health by prompt recognition of outbreaks and testing of samples associated with outbreaks as well as surveillance assignments as needed by the Vet-LIRN Program Office.

PI_NAMEs: LAWHON, SARA D. (contact)

PROGRAM_OFFICER_NAME: CERIC, OLGICA

PROJECT_TITLE: CVM Vet-LIRN Veterinary Diagnostic Laboratory Program (U18)


ORG_STATE: NY

PHR: PROJECT NARRATIVE The Chemical Biology Training Program at Stony Brook University trains students to work at the interface of chemistry and biology and to apply quantitative skills to solve biomedical problems so that they can make major contributions to the health and welfare of the United States. The training program provides students with skills to communicate the significance of their work to the public and provides a venue for discussing career plans and developing plans to successfully pursue their chosen career path. Training in chemical biology provides graduate students with the chemical and biological methods necessary for developing new and improved diagnostics and therapeutics.

PI_NAMEs: BOON, ELIZABETH M (contact);SEELIGER, JESSICA CHUANG

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Biology;Chemicals;Training

PROJECT_TITLE: Chemical Biology Training Interface


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Kidney Disease;Maternal Health;Pregnancy;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Chronic kidney disease affects more than 2 million American women of childbearing age, and is associated with decreased fertility and increased risk of adverse pregnancy outcomes. Planning for pregnancy prior to conception is advocated for all women but is especially important for women with kidney disease because of their potential complications. This research will develop and test a decision aid that will help women and their kidney doctors share information to support informed decision making related to reproductive health care and pregnancy in women with kidney disease.

PI_NAMEs: OLIVERIO, ANDREA L (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: acceptability and feasibility;Adult;adverse pregnancy outcome;Advocate;Affect;American;arm;Benefits and Risks;Biometry;Board Certification;career;career development;Caring;child bearing;Chronic Kidney Failure;Clinic;cohort;Collaborations;Communication;Computerized Medical Record;Conceptions;Conduct Clinical Trials;Counseling;Coupled;Data;Decision Aid;Decision Making;design;Development;Development Plans;Disease Management;Educational workshop;Effectiveness;effectiveness measure;effectiveness outcome;empowerment;Ensure;Etiology;Evaluation;evidence base;experience;Face;Female of child bearing age;Fertility;fetal;Fostering;Funding;Future;Goals;Grant;Health;Health education;Healthcare;high risk;High-Risk Pregnancy;improved;International;Internist;Intervention;Interview;K-Series Research Career Programs;Kidney;Kidney Diseases;Knowledge;Learning;Literature;Medicine;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Michigan;Morbidity - disease rate;Nephrology;offspring;Outcome;Patient Education;patient oriented;Patients;pediatrician;Physicians;pilot test;Planned Pregnancy;Population;Positioning Attribute;Pre-Eclampsia;Pregnancy;Pregnancy Outcome;premature;Preparation;Process;Prospective, cohort study;Randomized;Randomized, Controlled Trials;Regimen;Reproductive Health;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Risk;Sampling;satisfaction;Science;Scientist;Sexual Dysfunction;shared decision making;Site;skills;Structure;success;Surveys;Technology;Testing;Training;treatment as usual;Uncertainty;United States National Institutes of Health;Universities;Visit;Woman;Women's Health;women's reproductive health;Work

PROJECT_TITLE: Developing a decision aid for reproductive health for women with kidney disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]