ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Uveitis can lead to permanent vision loss and disability if not accurately detected and treated. Due to the subjective nature of clinical assessment and the potential imprecision of categorical data, objective measures of intraocular inflammation are needed. This multi-disciplinary workshop will support early career researchers and trainees in addition to bringing together a diverse roster of ophthalmologists, device representatives, and clinical trialists, to form new collaborations and address potential techniques for objective quantification of intraocular inflammation and their incorporation as endpoints in clinical trials, with the goal of improving patient outcomes.

PI_NAMEs: TSUI, EDMUND  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Address;American;anterior chamber;Anterior uveitis;Aqueous Humor;Area;Artificial Intelligence;Biological Markers;Blindness;Blood Vessels;career;career development;Cells;Childhood;Clinical;Clinical assessments;Clinical Research;Clinical Trials;Clinical Trials Design;clinically relevant;Collaborations;Data;Data Collection;Data Element;data standards;Detection;Development;Devices;disease model;Disease Surveillance;Early Diagnosis;Educational workshop;Environment;Evaluation;Event;experience;Extravasation;Eye;Eye diseases;Failure;Flare;follow-up;Fostering;Funding;Future;Goals;Grant;Health;Image;imaging biomarker;Immune system;improved;Industry;Infiltration;Inflammation;Inflammatory;Infrastructure;International;Knowledge Discovery;Measurement;Measures;Mind;Monitor;multidisciplinary;multiple data types;National Eye Institute;Nature;next generation;Nomenclature;Ophthalmologist;Outcome Measure;Patient-Focused Outcomes;Pharmacologic Substance;Play;Population;preservation;prevent;programs;Proteins;Publications;Reaction;Reproducibility;Request for Proposals;Research;Research Activity;research clinical testing;Research Personnel;Retina;Role;scientific organization;Societies;Specialist;Standardization;standardize measure;Techniques;Technology;Thinking;Travel;United States Food and Drug Administration;Uveitis;Validation;Vision;Visual disability;working group

PROJECT_TITLE: UCLA/American Uveitis Society 2nd International Workshop on Objective Measures for Use in Clinical Trials

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (12)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Immunotherapy;Machine Learning and Artificial Intelligence;Natural Products

ORG_CITY: DUARTE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: Project Narrative The Society for Integrative Oncology (SIO) 21st International Conference, " Full Circle Translational Integrative Oncology: Bedside to Bench and Back - The transformative power of clinical observation to ignite scientific discovery and optimize patient outcomes,” aims to encourage scientific and clinical collaboration across global boundaries to advance the knowledge, therapies, and care delivery of integrative oncology to improve quality of life and clinical outcomes. This conference will also continue to emphasize the training of diverse early career investigators and patient advocates in creating, interpreting, and disseminating evidence- based integrative oncology research, and increasing its potential clinical utility. Ultimately, it is our hope that this conference will provide renewed knowledge of the art and science of integrative oncology to improve patient care outcomes by integrative oncologists and other health care professionals working with individuals and their families living with cancer worldwide.

PI_NAMEs: LEE, RICHARD T (contact);LOPEZ, ANA MARIA

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Advocate;Artificial Intelligence;Back;Basic Science;bench to bedside;Canada;cancer care;cancer therapy;CAR T cell therapy;care delivery;care outcomes;career;Cities;Clinical;clinical application;clinical care;Clinical Trials;clinically relevant;Collaborations;Communities;County;Development;Discipline;diversity and equity;drug discovery;Education;Educational workshop;evidence base;experience;Family;Fostering;Future;Health;Health Professional;Immunooncology;Immunotherapy;improved;improved outcome;Individual;innovation;International;Knowledge;knowledge translation;Learning;lectures;Machine Learning;Malignant Neoplasms;meetings;member;metabolomics;Methods;Mind-Body Intervention;Minority;Natural Product Drug;Natural Products;next generation;nutrition;Oncologist;Oncology;Oral;Oranges;Outcome;Patient advocacy;Patient Care;Patient-Focused Outcomes;Patients;person centered;posters;practical application;Quality of life;Research;Research Methodology;Research Personnel;Science;Societies;Spirituality;symposium;Training;Training Support;translational approach;translational potential;Universities;Woman

PROJECT_TITLE: 21st International Conference of the Society for Integrative Oncology

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-E (M1)]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE Traumatic brain injury (TBI) is one of the top causes of death and disability worldwide, and one of the most challenging neurological conditions to treat due to its complexity. A multidisciplinary exchange of scientific ideas between trainees and investigators at all levels is therefore necessary to continue advancing our understanding of TBI, and to improve clinical care and public health outcomes. The Western Neurotrauma Symposium (WNTS) provided a forum for scientists and clinicians from across the western United States to spotlight our trainees and early investigators and has already initiated collaborations sharing data; and will continue to expand diversity and inclusivity in our field, generate new ideas and develop future research grant opportunities.

PI_NAMEs: PRINS, MAYUMI LYNN (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Address;Anxiety;Attention;Award;Basic Science;Behavioral Sciences;Biological Sciences;blind;Brain Concussion;Businesses;California;career;Cause of Death;Clinical;clinical care;Clinical Sciences;Collaborations;collaborative environment;Communications Media;Country;COVID-19 pandemic;Data;data sharing;Development;disability;disadvantaged student;Discipline;diversity and inclusion;Education;Engineering;Environment;Event;experience;Exposure to;Faculty;Female;Fostering;Funding;Funding Agency;Future;Goals;Grant;House Staffs;improved;Individual;Institution;International;Joints;Knowledge;Laws;Learning;Mathematics;meetings;Military Personnel;minority student;multidisciplinary;National Institute of Neurological Disorders and Stroke;Nervous System Trauma;Neurologic;Neurosciences;new growth;new technology;next generation;Outcome;outreach;Participant;Persons;physical science;Population Heterogeneity;Postdoctoral Fellow;Preparation;programs;Public Health;Race;Research;Research Personnel;Research Project Grants;Rest;Science;Scientist;senior faculty;sex;Soccer;social disparities;social media;Social Sciences;Societies;socioeconomics;Sports;student participation;Students;success;symposium;Time;Traumatic Brain Injury;Traumatic CNS injury;Travel;Underrepresented Populations;Underrepresented Students;United States;Universities;Woman;Work

PROJECT_TITLE: Western Neurotrauma Symposium 2024

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-K (45)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: WORCESTER

ORG_NAME: INTERNATIONAL SOCIETY OF VACCINES

ORG_STATE: MA

PHR: Project Narrative In an academic, non-commercial setting, the ISV Annual Congress uniquely brings together vaccine scientists from all sectors of basic research through clinical development, focused on technologies, best practices, policies, safety, and immunological challenges of different populations to target acute and chronic diseases in humans and animals. The ISV Annual Congress was held mainly in the US but also rotated among other continents to reach a global vaccine community. The 2024 ISV Annual Congress will be held in South Korea in collaboration with International Vaccine Institute (IVI) affiliated with the United Nations Development Programme (UNDP). The program will focus on the very latest epidemiological, scientific, and technological developments related to vaccines, while also providing crucial updates on fundamental scientific advances. ISV is devoted to its global membership, alternating Congress locations to bring together local, regional, and international researchers for fruitful exchange of information with simultaneous virtual offerings for persons unable to physically attend yet also interested in accessing the science and connecting with other scientists.

PI_NAMEs: WEINER, DAVID B. (contact)

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TERMS: Acute Disease;Address;Adjuvant;Affect;Affinity;Age;Animals;Antibodies;Antigens;Area;Artificial Intelligence;Asia;B-Lymphocytes;Basic Science;Biological Response Modifiers;career;Chronic;Chronic Disease;clinical development;clinical implementation;Clinical Trials;Collaborations;Communicable Diseases;Communication;Communities;Congresses;Country;COVID-19;Development;Disease;Disease Outbreaks;Domestic Animals;Elderly;Emerging Communicable Diseases;Ensure;Epidemic;Epidemiology;Equilibrium;Europe;Event;Feedback;Female;Funding;gain of function mutation;Geography;Global Warming;Goals;Grant;Health;Human;Humoral Immunities;Immune;immune activation;Immune response;Immune system;Immunity;immunogenicity;Immunoglobulin Somatic Hypermutation;Immunologic Stimulation;Immunologics;Immunologist;Immunosuppression;Immunotherapeutic agent;Individual;Infant;Infection;Infection prevention;Influenza;Ingestion;insight;interdisciplinary approach;interest;International;Learning;Life Cycle Stages;Location;low and middle-income countries;Malignant Neoplasms;manufacture;maternal vaccination;meetings;member;Mentors;microbiome;Mucosal Immunity;Mutation;National Institute of Allergy and Infectious Disease;Needles;Neonatal;neutralizing antibody;new technology;North America;novel vaccines;pandemic disease;pathogen;Persons;Policies;Population;posters;Poverty;Preventive vaccine;Program Development;programs;Prophylactic treatment;Recording of previous events;Research;research and development;Research Personnel;response;Rhinovirus;RNA vaccine;Rotation;Safety;Science;Scientific Advances and Accomplishments;Scientist;Senior Scientist;Site;Societies;South Korea;Specificity;Students;symposium;T cell response;T-Lymphocyte;Technology;technology development;technology platform;therapeutic vaccine;Time;tool;Toxic effect;Travel;United Nations;Update;Vaccination;Vaccine Antigen;vaccine development;Vaccine Research;vaccine strategy;Vaccines;vaccinology;Vector-transmitted infectious disease;virtual;Wild Animals;Work

PROJECT_TITLE: ISV - International Society for Vaccines 2024 Annual Congress

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 CAB-D (M1)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Mental Health;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: SANTA CRUZ

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative Understanding the neural circuit organization at great precision is a prerequisite to understand the brain functions underlying complex animal behaviors. In this proposed research, we will develop and validate two novel trans-synaptic virus tracer systems to delineate the neural connectivity orthogonally and rapidly. Our proposal has high levels of public health relevance because utilizing our methods to study brain connectivity will enhance understanding of neural circuit organization in both normal and diseased brains, which aligns with NIH’s mission to identify the circuit-specific therapeutic targets to cure brain disorders.

PI_NAMEs: KIM, EUISEOK J (contact)

PROGRAM_OFFICER_NAME: KIM, EUNYOUNG

PROJECT_TERMS: Anatomy;Animal Behavior;Animals;Area;autism spectrum disorder;Behavior;Brain;Brain Diseases;cell type;Cells;cholinergic;Complex;Corpus striatum structure;design;Development;Disadvantaged;Electronic Medical Records and Genomics Network;Engineering;experimental study;Gene Expression;Genomics;Glycoproteins;Hippocampus;in vivo;innovation;Interneurons;Label;Learning;Methods;Mission;Modeling;Monitor;Mus;neural;neural circuit;Neurodevelopmental Disorder;Neuronal Plasticity;Neurons;Neurosciences;novel;Organizational Productivity;Outcomes Research;Output;Parvalbumins;Perception;Population;presynaptic;presynaptic neurons;prevent;Process;public health relevance;Rabies;rabies viral tracing;Rabies virus;rabies virus barcoding;Rattus;Research;RNA Viruses;Schizophrenia;Sendai virus;Slice;Specificity;Synapses;System;Target Populations;Techniques;temperature sensitive mutant;Therapeutic;therapeutic target;timeline;tool;Tracer;United States National Institutes of Health;Variant;vector;Viral;Viral Vector;Virus;virus genetics;Visualization

PROJECT_TITLE: Diversity Supplement for a STEM diversity trainee in the lab


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: PORTLAND

ORG_DEPT: DERMATOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PUBLIC HEALTH RELEVANCE STATEMENT The Montagna Symposium on the Biology of Skin is a conference that has existed for nearly 70 years and creates a unique forum for researchers and physicians to discuss the latest scientific progress on aspects of skin biology that inform about the causes of skin disease. This conference brings together a diverse mix of health professionals and researchers from different fields whose multi-disciplinary interactions are needed to strategize and take action to develop new treatments for diseases involving skin. Over time, many breakthroughs in skin research discussed at the Montagna Symposium have shaped whole fields in science and medicine and the Symposium has also been a key career development step for young researchers and clinicians-in-training to meet and learn from renowned scientific leaders.

PI_NAMEs: LEACHMAN, SANCY ANN (contact);ROOP, DENNIS

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Address;Anniversary;Atmosphere;Award;Back;Basic Science;Biology;Body System;career development;Clinical;Clinical Investigator;Collaborations;Communication;Communities;cost;COVID-19 pandemic;Dermatologist;Dermatology;design;Diagnosis;Discipline;Disease;Dreams;Equilibrium;Fees;Fostering;Foundations;Future;Goals;Grant;grasp;Health;Health Professional;Human;Human Biology;Human body;human disease;innovation;innovative technologies;Journals;Knowledge;Learning;medical specialties;Medicine;meetings;Mission;Molecular;multidisciplinary;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;next generation;novel;Oregon;Organ;Paper;Participant;Patient Care;Peer Review;Persons;Pharmacologic Substance;Physicians;Production;programs;public health relevance;Publications;Regulation;Research;Research Personnel;Science;science and society;Scientific Advances and Accomplishments;Scientist;Shapes;Skin;skin color;skin disorder;Source;Specialist;Structure;symposium;Techniques;Time;tissue resident memory T cell;Training;translational potential;Travel;United States National Institutes of Health;Visualization;waiver

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Menopause;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE: RISE UP is a new breast cancer focused meeting that will bring together medical professionals from across women’s health specialties (e.g. oncologists, gynecologists, radiologists, primary care providers); basic scientists; advocates; entrepreneurs; policy makers; regulators and more, to establish new collaborations that could prove to be paradigm shifting in the breast cancer prevention space. Convening a group of interdisciplinary experts will reduce the silos that currently exist in academia, and create a dynamic, learning environment to energize the fight against breast cancer. Through three focus areas, we aim to leverage what we know about breast cancer detection, treatment and biology and hormonal management strategies to develop novel, innovative ways to approach breast cancer prevention.

PI_NAMEs: ESSERMAN, LAURA J (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Academia;Acceleration;Advocate;American;American Cancer Society;American College of Obstetricians and Gynecologists;American Society of Clinical Oncology;Area;Biology;Biotechnology;Breast;Breast Cancer Detection;Breast Cancer Prevention;Breast Cancer Risk Factor;Breast Cancer Treatment;cancer prevention;cancer subtypes;cancer therapy;Caring;Clinical Oncology;Collaborations;college;Communities;Community Healthcare;Contraceptive methods;design;Development;Discipline;educational atmosphere;Event;Fertility;fighting;Fostering;Funding;Generations;Goals;Gynecologic;Gynecologist;Health;Hormonal;Hormonal Change;Hormones;improved;Incidence;innovation;International;Intervention;Investigation;Investigational Therapies;Investments;Journals;Knowledge;knowledge integration;Leadership;Learning;Life;Life Cycle Stages;Link;Malignant Breast Neoplasm;Medical;medical specialties;meetings;member;Menopausal Symptom;Menopause;mortality;multidisciplinary;novel;Oncologist;Personal Satisfaction;Physicians;Policy Maker;posters;Postpartum Period;Prevention;Primary Care;primary care provider;Prize;Professional Organizations;Prognosis;programs;Publishing;radiologist;Research;Risk Reduction;San Francisco;Scientist;screening;Sexual Health;Silicon;Specialist;symposium;Thinking;Translating;trial design;tumor;Voice;Weaning;Woman;Women's Health;women's prevention;Work

PROJECT_TITLE: RISE UP for Breast Cancer


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: Los Angeles

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: This administrative supplement application is related to parent award U41 NS129514 “HORNET Center for Autonomic Nerve Recording and Stimulation Systems (CARSS)” which aims to develop and disseminate an open-architecture and open-source implantable system for autonomic nerve stimulation and recording system to support clinical research for bioelectronic medicine applications. The objective here is to perform short and long term validation of the CARSS system functionality in small and large animals for three intended use cases: bladder control, hypoglycemia, and unidirectional nerve block. Studies will include the implanted CARSS system components: (1) implantable pulse generator, (2) implantable leads for nerve stimulation; and (3) implantable leads for end-organ sensing.

PI_NAMEs: MENG, ELLIS  (contact);SONG, DONG

PROGRAM_OFFICER_NAME: HUDAK, ERIC MICHAEL

PROJECT_TERMS: Action Potentials;Acute;Address;Administrative Supplement;Animal Testing;Animals;Anterior;Architecture;autonomic nerve;bioelectronics;Biological Sciences;Bladder;Bladder Control;Bladder Dysfunction;Blood Glucose;Bluetooth;Catheterization;Cervical;Chronic;chronic inflammatory disease;Clinical;Clinical Research;clinical translation;Collaborations;Communication;Computer software;Continuous Glucose Monitor;Custom;Devices;Diameter;effectiveness validation;electric impedance;Electrodes;Evaluation;Event;Family;Family suidae;Feedback;Film;Frequencies;Heart failure;Heart Rate;Hyperglycemia;Hypoglycemia;Implant;implantation;implanted sensor;improved;Indiana;Insulin-Dependent Diabetes Mellitus;interest;Life;medical schools;Medicine;Minnesota;Modification;Monitor;multidisciplinary;Nerve;Nerve Block;nerve damage;neural;Neurogenic Bladder;neuroregulation;novel;open source;parent project;Patients;Periodicals;Persons;Physiologic pulse;Physiological;porcine model;prevent;programs;Readiness;Research Personnel;respiratory;Risk;Rodent;Safety;Sense Organs;sensor;Shapes;Sheep;Spinal cord injury;System;Techniques;Technology;Testing;Thinness;United States National Institutes of Health;Universities;Urodynamics;vagus nerve stimulation;Vagus nerve structure;Validation;Work


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CHARLES R. DREW UNIVERSITY OF MED & SCI

PHR: OVERALL PUBLIC HEALTH RELEVANCE South Los Angeles Service Planning Area 6, which comprises 68% Hispanic/Latino and 27% African American individuals, is one of the most underserved and under-resourced locations, with healthcare access and socioeconomic standards that are lower than any other county in Los Angeles and in the US. As a result, these communities have the highest incidence, morbidity, and mortality rates associated with cancer, cardiometabolic diseases, and HIV/AIDS. Our Program will focus on understanding how these socio-economic and environmental factors impact cellular, molecular, genetic, and epigenetic drivers that cause poor health outcomes in our communities, identifying opportunities for interventions to reduce health disparities.

PI_NAMEs: ANDALIBI, ALI ;TORRES-RUIZ, JOSE A (contact)

PROGRAM_OFFICER_NAME: ROUSSOS, GINA PATIENCE

PROJECT_TERMS: Acceleration;Address;African American population;Area;Basic Science;Behavioral;Behavioral Research;biomedical informatics;Budgets;Cardiometabolic Disease;cardiometabolism;Caring;Center for Translational Science Activities;Clinical;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community collaboration;community engaged research;community engagement;Community Outreach;Compassion;County;COVID-19 screening;Death Rate;Development;Discipline;drug discovery;Education;Environmental Risk Factor;Epigenetic Process;exosome;Faculty;Fostering;Funding;Genetic;Goals;health care availability;health disparity;Health Services Research;Hispanic;HIV/AIDS;implementation facilitation;improved;Incidence;Infrastructure;Institution;Intervention;Latino;Latinx;Location;Los Angeles;Malignant Neoplasms;Medicine;Mental Health;Mentors;MicroRNAs;minority health;minority health disparity;Mission;Modeling;Molecular;Monitor;Morbidity - disease rate;next generation sequencing;Outcome;pandemic disease;Pilot Projects;poor health outcome;Postdoctoral Fellow;precision medicine;Prevention;Process;Productivity;programs;public health relevance;Reduce health disparities;Research;research facility;research faculty;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;response;Schools;Science;Services;skill acquisition;Socioeconomic Factors;socioeconomics;statistics;Strategic Planning;Training;Translational Research;Universities

PROJECT_TITLE: Center for Accelerating Excellence in Translational Science (AXIS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 KNL (M1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

PI_NAMEs: VADGAMA, JAYDUTT V. (contact)

PROJECT_TERMS: Acceleration;Advisory Committees;Affect;Applications Grants;Area;Cardiometabolic Disease;career;Clinical Research;Clinical Services;Communication;Communities;community engagement;Dedications;Development;Documentation;Education;Educational workshop;Ensure;Evaluation;Event;Faculty;Funding;Future;Goals;Grant;health disparity;health equity;Health Professional;HIV/AIDS;Individual;Infrastructure;Institution;Journals;Leadership;Los Angeles;Malignant Neoplasms;Manuscripts;Mission;operation;outreach;Performance;Productivity;programs;Publishing;Research;Research Activity;Research Personnel;Research Project Grants;Resource Allocation;Resources;service engagement;Services;Social Justice;success;symposium;Training;Translational Research;Underserved Population;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WU, YANYUAN  (contact)

PROJECT_TERMS: Acceleration;Address;Affect;African American;Area;Behavior;Behavioral;Bioinformatics;Cells;Center for Translational Science Activities;ChIP-seq;Clinical;Clinical Research;cloud platform;Communities;community collaboration;community engagement;Community Outreach;community partners;community research;Computer Analysis;Computer software;Conduct Clinical Trials;Consultations;Data;Data Analyses;design;Development;Discipline;Disease;Disparity population;drug discovery;Educational workshop;Electronic Health Record;Endowment;Environment;epigenomics;ethnic minority;exome;exosome;Faculty;faculty community;Funding;Future;Gene Expression Profiling;genomic profiling;Genomics;Goals;Grant;Health;health disparity;health equity;Health Personnel;improved;Informatics;Infrastructure;Institution;laboratory equipment;Latinx;lectures;Link;Los Angeles;Methodology;methylome;MicroRNAs;Molecular Analysis;National Heart, Lung, and Blood Institute;National Institute on Minority Health and Health Disparities;Neighborhoods;next generation sequencing;Outcome;Outreach Research;Pathway interactions;Phenotype;PhenX Toolkit;Pilot Projects;Precision Health;precision medicine;Productivity;programs;Reduce health disparities;Research;Research Design;research facility;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Resources;Services;social;Social Behavior;social disparities;social health determinants;statistics;Students;Surveys;Techniques;Technology;The Cancer Genome Atlas;tool;Training;transcriptome sequencing;Translational Research;Work

PROJECT_TITLE: Research Capacity Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BAZARGAN, MOHSEN  (contact)

PROJECT_TERMS: Acceleration;Applications Grants;Appointment;Area;Award;Basic Science;Behavioral Research;Behavioral Sciences;biomedical informatics;Biomedical Research;built environment;career;career development;Center for Translational Science Activities;Clinical Research;Clinical Sciences;cohort;Collaborations;community engagement;Complement;Complex;Data;design;Development;Development Plans;Economically Deprived Population;Education;Educational workshop;Ensure;epigenomics;ethnic health disparity;Etiology;Extramural Activities;Faculty;Fostering;Funding;Genomics;Goals;Government;Grant;Grant Review;Health Disparities Research;health disparity;improved;Institution;institutional capacity;investigator training;Journals;Leadership;Los Angeles;Measurable;Medicine;Mentors;Minority;Minority-Serving Institution;National Institute of General Medical Sciences;National Institute on Minority Health and Health Disparities;new technology;PhenX Toolkit;Pilot Projects;post-doctoral training;Postdoctoral Fellow;Productivity;programs;Publications;racial health disparity;recruit;Reduce health disparities;Research;research and development;research faculty;Research Peer Review;Research Personnel;Research Project Grants;Research Support;Science;science teacher;Secure;Series;skills;skills training;social;socioeconomic disadvantage;Structure;success;Technology;tool;Training;Translational Research;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MARTINS, DAVID SANE (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;Affect;African American;African American population;Area;Awareness;Cancer Center;cancer health disparity;Cardiometabolic Disease;Clinical Research;Collaborations;Communities;community based participatory research;community collaboration;Community Developments;community engagement;community organizations;Community Outreach;community partners;community research;Compassion;COVID-19;Decision Making;Development;Dimensions;Disease;Education;empowerment;Ensure;Environment;Evaluation;Feedback;Feeling;forging;Fright;Frustration;Funding;Health Disparities Research;health disparity;Hearing;Hispanic;HIV/AIDS;Infrastructure;Institution;inter-institutional;interest;Knowledge;knowledge translation;Latino;Malignant Neoplasms;Medical;member;Methods;minority communities;Minority Groups;Modeling;multidisciplinary;novel;pandemic disease;Patients;Population Group;Provider;Recording of previous events;Reduce health disparities;Research;Research Personnel;Series;social;social media;Strategic Planning;success;synergism;System;translational approach;translational potential;Translational Research;Translations;Universities;Vaccination;vulnerable community;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine

PROJECT_TERMS: Acceleration;Address;Award;Bioinformatics;career;career development;Clinical Research;college;Data Science;Department chair;Development;Discipline of Nursing;drug discovery;Endowment;Ensure;Faculty;Funding;Grant;Health;Health Disparities Research;health disparity;improved;Individual;Institution;Leadership;Medical;Medicine;member;Mentors;Methods;multidisciplinary;next generation sequencing;Philanthropic Fund;Play;Population Sciences;Precision Health;precision medicine;Process;professor;public health relevance;Records;recruit;recruitment science;Research;Research Personnel;Research Support;Resources;role model;Science;Scientist;Senior Scientist;Series;Social Sciences;statistics;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Recruitment Core


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Childhood Leukemia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

PI_NAMEs: WU, YONG  (contact)

PROJECT_TERMS: absorption;Acceleration;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Affect;African American population;African American Women;analog;Animal Model;Animals;anti-cancer;anticancer activity;Apoptosis;Biological Assay;Black race;cancer care;Cancer cell line;cancer therapy;Categories;Cell Proliferation;Cells;Chemoresistance;chemotherapy;clinical application;Clinical Trials;Cohort Studies;combat;Combined Modality Therapy;design;Development;Disease;Dose;Drug Targeting;efficacy evaluation;Equilibrium;ethnic minority;Excretory function;Exhibits;Future;Germ-Line Mutation;Health;health disparity;high standard;Hispanic;improved;Incidence;inhibitor;innovation;insight;Lactate Transporter;leukemia;Leukemic Cell;Leukocytes;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Marketing;MDA MB 231;Metabolism;Methods;mouse model;Mus;Neoplasm Metastasis;novel;Outcome;overexpression;Patient-derived xenograft models of breast cancer;Patients;personalized approach;personalized medicine;Pharmaceutical Preparations;Phase;Phloretin;preclinical study;Process;Production;Prognosis;Recurrence;Research;Resources;Role;Safety;small molecule inhibitor;Specificity;Statistical Data Interpretation;success;Survival Rate;targeted treatment;Testing;Therapeutic;therapy outcome;Thinness;Toxic effect;Translational Research;Treatment Efficacy;Treatment outcome;treatment strategy;triple-negative invasive breast carcinoma;tumor;Xenograft procedure;young woman

PROJECT_TITLE: Development and Therapeutic Efficacy of a Novel Lactate Transporter inhibitor (MCT4) CB-202 in tumors that overexpress MCT4, such as Triple-Negative Breast Cancer (TNBC) and Acute Myeloid Leukemia (AL


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE We propose to study how family support affects the HIV-related health and mental health outcomes of Latino sexual minority men (LSMM) over time. We will conduct longitudinal data collection and cohort data analysis. We will interview LSMM and family members in Los Angeles, New York, and Miami to identify strategies for engaging family members in health promotion for LSMM.

PI_NAMEs: DEL PINO, HOMERO ERWIN (contact)

PROJECT_TERMS: Acceleration;Affect;AIDS prevention;Alcohol consumption;Anxiety;Behavior;behavior change;Behavioral;behavioral outcome;Biological;cohort;Cohort Studies;Conflict (Psychology);cultural values;Data;Data Analyses;Data Collection;Depressed mood;depressive symptoms;design;Disclosure;Disparity;Distress;Drug usage;Eligibility Determination;Emotional;experience;Family;Family health status;Family member;Family Relationship;Family Study;family support;Feeling suicidal;Focus Groups;Funding;Health;Health behavior;Health Promotion;HIV;HIV diagnosis;HIV Infections;HIV risk;Homophobia;improved;Incidence;Institutional Racism;Intervention;Interview;Latino;Latino Population;Latinx;Longitudinal Studies;Los Angeles;male health;Mediating;Medical;medical appointment;men;men who have sex with men;Mental Health;National Institute of Drug Abuse;New York;Not Hispanic or Latino;Outcome;perceived discrimination;Persons;physical conditioning;Population;Poverty;pre-exposure prophylaxis;Prevalence;Prevention;preventive intervention;Psyche structure;psychological symptom;psychosocial;racism;Random Allocation;Reporting;Research;Risk;Risk Behaviors;service providers;Sex Orientation;Sexual and Gender Minorities;sexual minority men;social stigma;social stressor;stem;Study of Latinos;substance use;Time;Translational Research;Treatment outcome;United States;Unsafe Sex;Viral;Viral Load result;Work;Youth

PROJECT_TITLE: Assessment of Latino SMM Family Relationships and Health Outcomes. Latino sexual minority men (LSMM)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Natural Products;Nutrition;Prostate Cancer;Urologic Diseases

PHR: Project Narrative The proposed project is anticipated to provide a highly effective novel regimen to enhance current treatment of advanced prostate cancer by using two natural products to synergize with chemotherapy drug, in order to reduce disparities in prostate cancer mortality in African-American patients. The combination of these natural compounds will provide additional benefits to patients in treatment of side effects associated with drug therapy.

PI_NAMEs: WANG, PIWEN  (contact)

PROJECT_TERMS: ABCC1 gene;abiraterone;Acceleration;advanced prostate cancer;Adverse effects;Adverse event;Affect;African American;Allium cepa;American;androgen independent prostate cancer;Animal Model;Animals;anti-cancer;Apoptosis;Apoptotic;Apple;arm;Benefits and Risks;Biological Availability;biomarker identification;Blood;Bone Marrow Suppression;cancer health disparity;Cancer Patient;capecitabine;Carrier Proteins;Catechol O-Methyltransferase;Caucasians;Cell Cycle Arrest;Cell Line;Cells;Chemoresistance;chemotherapy;Clinical;Clinical Treatment;Clinical Trials;cohort;Consumption;Control Groups;CWR22Rv1;design;Disease;disparity reduction;docetaxel;Dose;Dose Limiting;Drug Combinations;Drug Kinetics;efficacy evaluation;Enrollment;enzalutamide;Enzymes;Epigallocatechin Gallate;Flavonoids;Goals;Green tea;health care availability;health disparity;Human;improved;In Vitro;in vivo;Induction of Apoptosis;Inhibition of Cell Proliferation;inhibitor;Knockout Mice;LNCaP;Malignant neoplasm of prostate;men;Methylation;Microtubule Depolymerization;Mitosis;mortality;mouse model;Multidrug Resistance-Associated Proteins;Natural Compound;Natural Products;Nature;neoplastic cell;Neutropenia;NF-kappa B;Normal Cell;novel;overexpression;Pathway interactions;Patients;PC3 cell line;Pharmaceutical Preparations;Pharmacotherapy;Phase;phase 1 designs;phase 1 study;phase 2 study;Phase I/II Trial;Phase III Clinical Trials;phase III trial;Phenotype;PIK3CG gene;Placebos;Prednisone;primary endpoint;Property;Prostate;prostate cancer cell;Prostate Cancer therapy;PSA level;PTEN gene;Quercetin;Randomized;randomized trial;Recommendation;recruit;red wine;Regimen;Resistance;response;Risk;Safety;Signal Transduction;standard care;standard of care;success;synergism;Testing;Therapeutic Effect;Toxic effect;Translational Research;Treatment Side Effects;tumor;tumor DNA;tumor growth;tumor xenograft;Up-Regulation;Validation;Vinorelbine;Xenograft Model

PROJECT_TITLE: Phase I/II trial of green tea and quercetin in docetaxel chemotherapy


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Immunotherapy;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The studies outlined in this proposal aim to determine the mechanisms by which activating protein-1 (AP-1) influences natural killer (NK) cell development and function in the setting of acute myeloid leukemia (AML). Our comprehensive approach will allow for a deeper understanding of the developmental and functional consequences of AP-1 pathway signaling in NK cell precursors and mature NK cells in the setting of AML. The studies outlined in this proposal will reveal novel mechanisms that hinder NK cell development and function in AML.

PI_NAMEs: JEREMY, ERIN G. (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: activating transcription factor;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Automobile Driving;Blood Cells;cancer cell;Cell Line;Cell Maturation;Cell Physiology;Cell Separation;Cells;checkpoint receptors;Chromatin;Clinical;Cre lox recombination system;Data;Defect;design;Development;Diagnosis;dimer;DNA Methylation;Epigenetic Process;epigenetic profiling;exhaustion;Family;FOS Protein;Functional impairment;Gene Expression Profiling;Genetic Transcription;Hematologic Neoplasms;Homeostasis;Human;Immune;immune checkpoint;Immune Evasion;Immunologic Surveillance;Immunotherapeutic agent;Impairment;In Vitro;in vivo;in vivo Model;inhibitor;Interferon Type II;leukemia;leukemia relapse;Lymphoid Cell;MAPK8 gene;Mediating;MEK inhibition;MEKs;mouse model;Mus;Myelogenous;Natural Killer Cells;novel;Outcome;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Play;Post-Translational Protein Processing;Precursor Natural Killer Cell;preservation;prevent;Production;programs;Proteins;Regulation;Role;Series;Signal Pathway;Signal Transduction;small molecule inhibitor;stem cells;Survival Rate;targeted treatment;Testing;Therapeutic;therapeutic target;therapeutically effective;transcription factor;Transcriptional Activation;transcriptome sequencing;Treatment Efficacy;Work;Xenograft Model

PROJECT_TITLE: The roles of AP-1 pathway activation in NK cell development and exhaustion programming in AML


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Sleep Research

ORG_CITY: FALLS CHURCH

ORG_NAME: D-PRIME LLC

ORG_STATE: VA

PHR: Project Narrative Insomnia is a highly prevalent disorder with significant health and economic impacts. Unfortunately, the development of therapeutics for insomnia is hindered by suboptimal sleep assessment in clinical trials. This project proposes to further develop the improved patient reported outcome (iPRO) - Sleep Diary, a platform technology, to improve sleep assessment and to optimize therapeutic development for insomnia.

PI_NAMEs: BROOKS, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Address;Agreement;Algorithms;Beds;Behavior;Clinical;clinical development;clinical outcome assessment;clinical practice;Clinical Trials;Collection;commercialization;comorbidity;contextual factors;Data;Data Aggregation;Data Reporting;design;Development;Devices;Diagnostic;diaries;Disease;drug development;Economic Burden;economic impact;effective therapy;efficacy evaluation;Ensure;Error Sources;experience;feasibility testing;Feedback;Freedom;Health;improved;improvement on sleep;Individual;interest;Intervention;Interview;Measurement;Measures;meetings;Mental Health;Methods;Modification;Moods;novel;novel therapeutics;Online Systems;operation;Outcome;Patient Education;Patient Outcomes Assessments;patient retention;Patient Self-Report;Patients;Phase;Phase II Clinical Trials;physical conditioning;Pilot Projects;Population;preservation;primary outcome;Program Appropriateness;Program Development;programs;prototype;Qualifying;Quality of life;Randomized;Reporting;response;Self Assessment;Self Perception;sensor;signal processing;Signal Transduction;Sleep;Sleep Disorders;sleep onset;Sleeplessness;Small Business Innovation Research Grant;Source;Structure;Symptoms;System;technology platform;theories;Therapeutic;therapeutic development;therapeutically effective;Time;tool;tool development;Treatment Efficacy;treatment group;Unconscious State;wearable data;wearable device

PROJECT_TITLE: Improved Patient Reported Outcomes (iPRO) -Sleep Diary: A Tool to Improve Sleep Assessment in Clinical Trials


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: ANN ARBOR

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project narrative An administrative supplement is requested to replace a nearly broken/aging 4-deg deli fridge and -80-deg freezer. Both equipment are essential for our research since they store our biological reagents and samples.

PI_NAMEs: LIU, ALLEN PO-CHIH (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Adhesions;Adhesives;Administrative Supplement;Affect;Aging;Apoptosis;Behavior;Binding;Biochemical;Biocompatible Materials;Biological;biological adaptation to stress;Biological Markers;Biomimetics;Blood Platelets;Blood Vessels;Calcium;Calpain;cancer cell;Cardiovascular system;Cell Death;cell killing;Cell model;Cell Therapy;cell type;Cells;chimeric antigen receptor;Coculture Techniques;Communication;Complex;Coupling;Cytoplasmic Granules;Data;density;Development;Disease;Encapsulated;Endothelial Cells;Engineering;Environment;Enzymes;Epidermal Growth Factor Receptor;Equipment;Exocytosis;exosome;experience;Extracellular Matrix;Future;Goals;Growth;hemodynamics;Human body;Hybrids;Immunotherapy;In Vitro;innovation;intercellular communication;interest;Lateral;Ligands;Lipid Bilayers;Liquid substance;Location;Lytic;Mammalian Cell;Measures;mechanical force;Mechanics;mechanotransduction;Mediating;Membrane;Membrane Fusion;membrane reconstitution;Modeling;Monitor;Morphology;novel;Oxidation-Reduction;Pathology;Patients;Peptides;Physiological;Polymers;prevent;Probability;Process;Proliferating;Property;Reagent;receptor binding;reconstitution;Research;Research Personnel;response;Sampling;shear stress;Signal Transduction;Signal Transduction Pathway;Specificity;stem cells;Stimulus;success;Surface;synthetic biology;System;T-Lymphocyte;Techniques;technology platform;Testing;Therapeutic;Tissues;tool;tumor;Variant;Vascular Endothelial Growth Factors;Vesicle;Work

PROJECT_TITLE: Development of a mechanosensitive synthetic cell for mediating intercellular communication - Administrative Supplement


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Obesity and subsequently type 2 diabetes are increasingly common in pubertal youth, and with a greater degree of insulin resistance, earlier onset of beta-cell failure, and earlier need for insulin therapy than in adults. Medication responses in existing studies in youth-onset type 2 diabetes are poorer than similar studies in adults, with evidence that this aggressive phenotype is leading to earlier onset of diabetes complications. As a result, we now propose to recruit youth with obesity early in puberty and follow them longitudinally over time with serial assessments of insulin sensitivity and secretion, free-living glycemia, physical activity and sleep, mental health and stress, body composition, pubertal stage, and store samples for additional future analyses, with a new focus on understanding the unique, early contributors to development of type 2 diabetes in youth.

PI_NAMEs: KELSEY, MEGAN MORIARTY;NADEAU, KRISTEN JANE (contact)

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: Adolescent;Adult;adverse childhood events;Affect;Age;Behavioral;Beta Cell;biobank;Body Composition;Body mass index;Cell Physiology;Circadian Rhythms;comparison control;Complications of Diabetes Mellitus;critical period;Deterioration;Development;Diabetic Angiopathies;Diagnostic;early onset;Enrollment;Ethnic Origin;Failure;Family;Feedback;follow-up;Funding;Future;glycemic control;Health Care Costs;health disparity;high risk;Hormones;impaired glucose tolerance;Incidence;Individual;innovation;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;Lead;medication compliance;Mental Health;Metformin;Morbidity - disease rate;National Institute of Diabetes and Digestive and Kidney Diseases;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Oral;Pharmaceutical Preparations;Phenotype;phenotypic data;Physical activity;Physiological;Play;Poverty;prevent;Productivity;psychosocial;Puberty;racial minority;racism;Recording of previous events;recruit;Research Personnel;response;Risk;Risk Factors;Role;rural area;Sampling;screening;sedentary lifestyle;Site;Sleep;social health determinants;Stress;Time;treatment response;type 2 diabetes in children;urban area;Youth

PROJECT_TITLE: What Activates Type 2 Diabetes in Children (WATCh)?


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE We propose a hybrid type III effectiveness – implementation trial designed to evaluate best practices for deploying the Screen & Treat approach to cervical cancer screening utilizing self-collected HPV DNA testing within Mozambique´s HIV care and treatment services. This proposal will employ a mixed-method approach, collecting both quantitative and qualitative data. The primary outcome of interest is the number of women screened and the proportion of HPV screen-positive women undergoing treatment, while secondary outcomes will focus on other implementation outcomes, and if successful, will be utilized to inform future research to take this approach to scale across Mozambique.

PI_NAMEs: MOON, D. TROY (contact);SACARLAL, JAHIT ;SALCEDO, MILA DE MOURA BEHAR PONTREMOLI

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: Ablation;Acetic Acids;Acquired Immunodeficiency Syndrome;Address;Africa South of the Sahara;Age;aged;Cancer Control;Cancer Detection;care systems;Caring;Cervical;Cervical Cancer Screening;Cessation of life;Classification;clinical care;Cold Therapy;Collection;Consolidated Framework for Implementation Research;Country;Data;Death Rate;design;detection sensitivity;DNA;Early treatment;Educational workshop;effectiveness evaluation;effectiveness/implementation trial;Eligibility Determination;Equity;Evidence based practice;Exercise;experience;follow-up;Health care facility;Health Personnel;Health Professional;health training;high risk;high risk population;HIV;HPV positive;HPV screening;Human Papillomavirus;Hybrids;implementation outcomes;implementation/effectiveness;Improve Access;improved;Incidence;interest;Intervention;Intervention Trial;Interview;Knowledge;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Methods;model building;Mozambique;Participant;pragmatic intervention;premalignant;Prevalence;primary outcome;Process;programs;Provider;Recommendation;Reporting;routine care;Sampling;scale up;screening;screening program;secondary outcome;Site;Standardization;Testing;treatment services;trial design;University of Texas M D Anderson Cancer Center;uptake;Vaccination;Variant;Virus;Visit;Visual;Woman;World Health Organization

PROJECT_TITLE: A hybrid type III effectiveness-implementation, pragmatic intervention trial for cervical cancer screen and treat in Mozambique

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-M (M2)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: CINCINNATI

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative The research proposed here will investigate magnetic nanoparticles as novel drug delivery vehicles for the treatment of hearing loss using a preclinical animal model. Our goal is to understand how the physical and chemical properties of magnetic nanoparticles impact their performance as drug delivery vehicles in the ear.

PI_NAMEs: SUN, DANIEL Q (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Affect;Animal Model;Behavior;Biodistribution;Biological;Biological Assay;biomaterial compatibility;Brain-Derived Neurotrophic Factor;cancer therapy;career;Cavia;Chemical Engineering;chemical property;Clinic;Clinical;clinical translation;Clinical Treatment;Cochlea;cochlear development;Custom;Data;delivery vehicle;Development;Devices;Diffusion;DNA;Drug Delivery Systems;Drug Kinetics;Ear;Engineering;Equilibrium;Ethics;experience;Face;gene therapy;General Anesthesia;Goals;Growth Factor;guinea pig model;Head and Neck Surgery;Hearing;hearing impairment;hearing loss treatment;Histologic;Histology;Human;Image;Implant;improved;In Vitro;in vivo;Injections;inner ear diseases;interest;iron oxide;K-Series Research Career Programs;Labyrinth;Lead;Liquid substance;macromolecule;magnetic field;Magnetic nanoparticles;Magnetism;Mediating;Mediator;medical schools;Membrane;Mentors;middle ear;minimally invasive;Modeling;molecular size;nanoparticle;Needles;neuronal growth;novel therapeutics;Nucleic Acids;Operative Surgical Procedures;Otolaryngology;particle;Particle Size;Patients;Penetration;Performance;Perilymph;Pharmaceutical Preparations;pharmacokinetic model;Pharmacy (field);physical property;Polyethylene Glycols;Polymers;pre-clinical;Predisposition;professor;Property;Proteins;rational design;Research;Residual state;Risk;round window;Scala Tympani;Science;Scientist;Sensorineural Hearing Loss;Severities;skill acquisition;small molecule;Study models;superparamagnetism;Surgeon;Techniques;Technology;Temporal bone structure;Therapeutic;Tissues;Training;Universities;validation studies;Viral Vector

PROJECT_TITLE: Rational Design of Magnetic Nanoparticles for Cochlear Drug Delivery

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE We expect the knowledge learned from this research to support the initial steps of a paradigm shift towards adolescence as a crucial period for exposure remediation and risk reduction to maintain lifelong cardiometabolic health.

PI_NAMEs: ARGOS, MARIA  (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Adverse effects;Affect;Age;aged;Arsenic;Bangladesh;Biological Aging;Biometry;Biosensor;Blood Pressure;Body mass index;C-reactive protein;Cadmium;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular risk factor;Child Health;Childhood;Cholesterol;Clip;cohort;Data;Development;disease registry;disorder prevention;Disparity population;DNA;DNA Methylation;Environment;Environmental Risk Factor;epidemiology study;epigenome;exposed human population;fasting plasma glucose;Frequencies;Functional disorder;Future;General Population;Goals;Health;high risk;improved;Individual;innovation;insight;Insulin;Knowledge;Laboratories;Lead;Learning;Length;Leukocytes;Life;Life Cycle Stages;Literature;Measures;Mediation;Mercury;Metal exposure;Metals;Methods;Methylation;novel;Outcome;participant enrollment;Pathogenesis;Phenotype;Poison;Population Study;Predisposition;Public Health;remediation;Research;Resources;Risk Reduction;Rural;Sampling;Site;Spottings;Structure of nail of toe;telomere;Testing;Time;Toxic effect;toxic metal;trait;Urine;Visit;Vulnerable Populations;Whole Blood;Youth

PROJECT_TITLE: Impact of Metals on Biological Aging and Cardiometabolic Traits in Adolescents

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Endocrine Disruptors;Prevention;Rare Diseases

ORG_CITY: Fort Lauderdale-Davie

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NOVA SOUTHEASTERN UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Organofluorine compounds, PFAS (per- and polyfluoroalkyl substances) have generated increased public attention due to their ubiquitous presence in the environment and their association with toxicity, especially as a potential risk factor for cancer. This administrative project aims to identify the possible PFAS effects on head and neck cancer invasiveness. The results could provide insight into the potential association between PFAS and head and neck cancer risks, especially for personnel who are occupationally exposed to higher amounts of PFAS.

PI_NAMEs: SUZUKI, MAIKO  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Administrative Supplement;Adverse effects;Ameloblasts;Attention;Award;Behavioral Research;Biological;Biological Assay;Biomedical Research;Cancer cell line;cancer invasiveness;cancer risk;cancer type;Carcinoma;Cell Line;cell motility;Cells;Cellular Stress;craniofacial;Data;Dental;Dental Enamel;Development;Enamel Formation;Environment;Environmental Pollutants;Environmental Risk Factor;Epigenetic Process;Epithelium;Exposure to;Fluorides;Functional disorder;Generations;Grant;Head and Neck Cancer;Health;Human;Human Resources;improved;In Vitro;in vitro Model;in vivo;insight;malformation;malignant mouth neoplasm;Malignant Neoplasms;Malignant Squamous Cell Neoplasm;Mediating;Mesenchymal;Molecular;Mouth Diseases;Mus;Neoplasm Metastasis;novel;Occupational Exposure;Oral;Oxidative Stress;Parents;Pathology;perfluorooctanoic acid;Periodontitis;Play;Poly-fluoroalkyl substances;Preventive;Research;Research Project Grants;Risk Factors;Role;SIRT1 gene;Squamous cell carcinoma;Testing;Therapeutic;Time;Tooth structure;Toxic effect;United States National Institutes of Health;wound healing

PROJECT_TITLE: Epigenetic and Non-epigenetic Role of SIRT1 in Fluoride-induced Cell Stress Administrative Supplement.


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE The island of Puerto Rico has experienced 3 major back-to-back public health emergencies over the past 3 years: Hurricane Maria, a swarm of earthquakes, and the COVID-19 pandemic. This study will use three different but complementary sources of quantitative and qualitative data to study the impact of these public health emergencies on the preparedness, response, recovery and resiliency, as well as patient health care experiences and utilization, among general hospitals and community clinics across the island.

PI_NAMEs: CHAVEZ, LIGIA M.;ORTEGA, ALEXANDER N (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Accident and Emergency department;Adult;Affect;analytical method;Asthma;Back;barrier to care;burden of illness;burnout;Businesses;care systems;Caring;Cellular Phone;Chronic Care;Clinic;Clinics and Hospitals;cohort;Communicable Diseases;Communities;community clinic;Community Health;COVID-19;COVID-19 pandemic;Data;design;Diabetes Mellitus;Dialysis procedure;Disasters;Earthquakes;Electricity;Elements;Emergency Situation;Environmental Hazards;Epidemic;Equipment;Event;experience;Floods;follow-up;Frequencies;Funding;General Hospitals;Government;Health;health care availability;health care delivery;health care disparity;Health care facility;health care service;health care service utilization;health disparity;health disparity populations;Health Personnel;Health Policy;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Homelessness;Hospitals;Hurricane;informant;Infrastructure;insurance claims;Insurance Coverage;Interview;Island;Left;Literature;Long-Term Effects;Measures;Medicaid;Medical;medical supply;Methods;Minority Groups;Modeling;Natural Disasters;novel coronavirus;Occupations;Operative Surgical Procedures;Out-Migrations;Ownership;pandemic disease;patient-level barriers;Patients;Pharmaceutical Preparations;Pharmacy facility;Phase;Poverty;Preventive care;Privatization;Provider;Public Health;public health emergency;Publishing;Puerto Rican;Puerto Rico;Quality of Care;Readiness;Recommendation;Recovery;Research;resilience;Resources;response;Risk Management;Rural;Sampling;Series;Services;Source;Stress;Surveys;System;Time;trend;Unemployment;Uninsured;Water

PROJECT_TITLE: The Puerto Rico Healthcare System Before and After Three Public Health Disasters

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Precision Medicine;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative  The parent award for this administrative supplement aims to identify and validate early-emerging neurobiological markers of ASD that occur before behavioral symptoms manifest to serve as diagnostic, risk, and/or treatment response biomarkers of social dysfunction in ASD. This administrative supplement seeks funding for additional personnel effort to support the continuity of the project following the principal investigator’s critical life event of childbirth.

PI_NAMEs: PUGLIA, MEGHAN H (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Administrative Supplement;Adolescent;Adult;Age;Age Months;aged;Algorithms;Architecture;autism biomarker;autism spectrum disorder;autism symptoms;autistic;autistic behaviour;autistic children;Behavior;behavior observation;Behavioral;Behavioral Symptoms;Biological Markers;biomarker development;biotypes;Brain;Caliber;career;Child;Child Health;Childbirth;Classification;Clinical;Clinical Trials;cognitive ability;cognitive development;cognitive neuroscience;cognitive performance;cohort;Collaborations;Coupling;Data;Data Science;Data Set;Dedications;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Dimensions;Disease;DNA Methylation;Early identification;Early Intervention;effective intervention;Electroencephalography;Enrollment;Entropy;Environment;epigenetic marker;Epigenetic Process;epigenome;Event;Foundations;Funding;Genetic;Goals;Heterogeneity;Human Resources;improved outcome;Individual Differences;individualized medicine;Infant;large scale data;Lead;Life;Link;longitudinal dataset;Longitudinal Studies;Measures;Mentors;Modeling;Nature;neural;neural network;Neurobiology;Neurocognitive;neurodevelopment;neurophysiology;Neurosciences;Noise;novel marker;Outcome;Oxytocin;Oxytocin Receptor;parent project;Pathway interactions;Play;precision medicine;Prediction of Response to Therapy;Predictive Analytics;Premature Infant;Principal Investigator;programs;public health priorities;Receptor Gene;Research;response biomarker;Rest;Risk;Role;Sampling;Sensitivity and Specificity;Series;sex;Signal Transduction;Signs and Symptoms;Social Behavior;social deficits;Social Perception;Stratification;Testing;Time;Training;Treatment outcome;treatment planning;treatment response;Universities;Virginia;Work

PROJECT_TITLE: Temperodynamic neural variability as an early-emerging biomarker of autism spectrum disorders


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Half of all Black men who have sex with men in the United States will get HIV in their lifetime despite engaging in less risky sexual behaviors than men who have sex with men of other racial and ethnic identities. This study will explore relationships of different discrimination experiences and sexual health among young Black men who have sex with men (YBMSM). This study aims to better the sexual health of YBMSM throughout their lives by informing future interventions that helps decrease new cases of HIV and other poor sexual health outcomes.

PI_NAMEs: JANEK, SARAH ELISE (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Address;Age;age group;Age Years;AIDS prevention;Appearance;Awareness;Behavior;Bisexual;black men who have sex with men;Black race;cisgender;community engaged research;community engagement;condomless anal sex;Data;design;Development;Discrimination;Distress;Education;Educational workshop;emerging adult;ethnic diversity;ethnic identity;Ethnic Origin;experience;Fellowship;Foundations;Funding;Future;Gays;gender minority group;Goals;health equity;health inequalities;Health Promotion;Healthcare;Heterogeneity;high risk sexual behavior;Hispanic;HIV;HIV disparities;HIV Infections;improved;Incidence;Income;Individual;Inequity;insight;intersectionality;Intervention;Interview;Knowledge;large datasets;Latino;Letters;Masculine;men who have sex with men;Mentorship;Methods;Minority;Minority Groups;Mission;National Institute of Nursing Research;Outcome;Parents;Participant;Pattern;perceived discrimination;Phase;Population;population health;post-doctoral training;pre-exposure prophylaxis;Prejudice;Race;racial diversity;racial identity;racial minority;Research;Research Personnel;Risk;Sampling;School Nursing;sex;Sex Orientation;Sexual and Gender Minorities;Sexual Health;sexual identity;sexual minority;sexual minority group;sexual minority health;sexual risk behavior;Sexually Transmitted Diseases;Shapes;skill acquisition;skills;Source;Stereotyping;Strategic Planning;Structure;Subgroup;System;Testing;theories;therapy development;Time;Training;transgender women;United States;United States National Institutes of Health;Universities;Unsafe Sex;Variant;Work

PROJECT_TITLE: Intersectional Discrimination and Sexual Health Among Young Black Men who Have Sex with Men: A Mixed Methods Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17B-K (20)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Tuberculosis (TB) is a serious world health problem. A better understanding of Mycobacterium tuberculosis (Mtb) biology and pathogenesis will aid efforts to develop novel strategies for controlling TB. The goal of this proposal is to define the molecular mechanisms of the Mtb SatS protein, which is a novel protein export chaperone required for Mtb pathogenesis. The knowledge gained from these studies will expand our fundamental understanding of bacterial protein export pathways and it has the potential to reveal new drug and vaccine development opportunities for TB.

PI_NAMEs: BRAUNSTEIN, MIRIAM S. (contact);SACCHETTINI, JAMES C

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Antigens;Antitubercular Agents;Attenuated Vaccines;Bacterial Physiology;Bacterial Proteins;Binding Sites;Biochemical;biological systems;Biology;biophysical analysis;Categories;cell envelope;Cessation of life;Complex;Cytoplasm;Data;Development;drug development;Engineering;Environment;Epidemic;Exhibits;extracellular;Future;Genetic;Genus Mycobacterium;Goals;Growth;Health;Hydrophobicity;Immune response;improved;Infection;Interdisciplinary Study;Knowledge;Label;Laboratories;Length;Lipids;Macrophage;Measures;Molecular;Molecular Biology;Molecular Chaperones;mycobacterial;Mycobacterium tuberculosis;novel;novel strategies;novel therapeutics;Pathogenesis;pathogenic bacteria;Pathway interactions;Peptides;Phagosomes;Phosphoric Monoester Hydrolases;Play;prevent;Protein Export Pathway;Proteins;Proteomics;Qualifying;Research Personnel;Roentgen Rays;Role;stoichiometry;Structure;Substrate Specificity;Testing;tool;Tuberculosis;tuberculosis treatment;vaccine development;Virulence;World Health

PROJECT_TITLE: A novel protein export chaperone of Mycobacterium tuberculosis

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Aging;Bioengineering;Cardiovascular;Clinical Research;Health Services;Heart Disease;Networking and Information Technology R&D (NITRD);Prevention;Telehealth

ORG_CITY: NASHVILLE

ORG_NAME: VOLUMETRIX, LLC

ORG_STATE: TN

PHR: Project Narrative Decompensated HF is the leading cause of hospitalization. HF leads to water accumulation in the tissues (lungs and legs) resulting in shortness of breath and leg swelling. This project will advance the development of an accurate, inexpensive, easy to use device (“NIVAHF”) for volume measurements in patients with HF. Use of these devices will ultimately help health care providers and patients prevent water overload. The long-term goal is to prevent costly hospital readmissions, improve quality of life, and reduce mortality in patients with HF.

PI_NAMEs: HOCKING, KYLE MITCHELL (contact);LINDENFELD, JOANN

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Academic Medical Centers;Advanced Development;Algorithm Design;Android;Awareness;Blood capillaries;Breakthrough device;Cardiac Catheterization Procedures;Categories;Certification;Clinic;Clinical;Collaborations;commercialization;Communication;Companions;Congestive Heart Failure;COVID-19;Data;Dehydration;design;Development;Device Designs;Devices;diagnostic tool;Dialysis patients;Disease;Durable Medical Equipment;Early identification;Edema;effective therapy;Elderly;Electronic Health Record;Environment;Evaluation;experience;Experimental Animal Model;Fast Healthcare Interoperability Resources;Freezing;global health;Goals;Health Personnel;Healthcare;Heart failure;hemodynamics;Home;Home environment;Hospital Costs;hospital readmission;Hospitalization;Hospitals;Human;Impairment;improved;Incidence;Industry Standard;Laboratories;Lead;Leg;Legal patent;Licensing;Life;life span;Limb structure;Lung;manufacture;Measurement;Measures;Medical;Medicare;meetings;member;Military Personnel;mobile application;Modification;Monitor;Morbidity - disease rate;mortality;non-invasive monitor;novel;older patient;Outpatients;patient population;Patients;pediatric patients;Peripheral;Phase;Physicians;Physiologic Monitoring;Physiological;pressure;prevent;Process;Provider;Pulmonary Capillary Wedge Pressure;Qualifying;Quality of life;Recurrence;remote monitoring;Shortness of Breath;Signal Transduction;Signs and Symptoms;Small Business Innovation Research Grant;Specific qualifier value;Swelling;Symptoms;Technology;telehealth;Telemedicine;Tissues;trend;Triage;usability;validation studies;Venous;virtual;Water;wearable device;Work

PROJECT_TITLE: Non-Invasive Venous Waveform Analysis (NIVA) in patients with Heart Failure (HF)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Withdrawal avoidance plays a major role in motivated opioid seeking and relapse. The intricate somatic and affective symptoms that accompany opioid withdrawals suggest that brain-wide investigation of the neural mechanisms underlying withdrawals is necessary to understand this complex disorder. This proposal aims to elucidate a brain-wide network mechanism underlying behavioral dysfunction and pathophysiology in opioid withdrawal.

PI_NAMEs: ABDELAAL, KARIM  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: addiction;Address;adverse outcome;Affect;Affective Symptoms;Amygdaloid structure;Area;avoidance behavior;Behavior;Behavioral;behavioral response;Biological Assay;Brain;BRAIN initiative;Brain region;career;career development;Cell Physiology;cell type;Cells;Characteristics;Chronic;cingulate cortex;Code;cohort;Communication;Communities;Complex;Consumption;Creativeness;Custom;Data Analyses;Data Set;Decision Making;design;Development;Disease;Dissociation;Doctor of Philosophy;Down-Regulation;Drug Addiction;Drug Metabolic Detoxication;Electrodes;Electrophysiology (science);experience;Experimental Designs;experimental study;explainable machine learning;Exposure to;Family;Fellowship;Foundations;Frequencies;Functional disorder;Future;Gene Expression Profiling;Goals;Health;high risk;in vivo;in vivo monitoring;Incidence;Individual;interest;Intervention;Intravenous;Investigation;Leadership;learning network;Link;machine learning model;Mediating;Mentors;Mentorship;Modeling;Molecular;Molecular Profiling;Monitor;Motivation;Mus;negative affect;negative emotional state;network models;neural;neural circuit;neuroimaging;neuromechanism;neurophysiology;neuropsychiatry;Neurosciences;novel;novel therapeutics;Nucleus Accumbens;Opioid;opioid abuse;opioid exposure;opioid use;opioid use disorder;opioid withdrawal;optogenetics;oral communication;Overdose;Pattern;Pharmaceutical Preparations;Phase;Phenotype;Play;Positioning Attribute;Positive Reinforcements;Postdoctoral Fellow;pre-doctoral;Prefrontal Cortex;prevent;Relapse;relapse risk;Research;Research Personnel;Research Priority;Research Project Grants;response;Rewards;Role;Self Administration;Severities;Signal Transduction;Site;skill acquisition;skills;skills training;spatiotemporal;Structure;Substance Use Disorder;success;System;Technical Expertise;Techniques;Testing;theories;Therapeutic;therapeutic target;tool;Training;Ventral Tegmental Area;Withdrawal;Withdrawal Symptom;Work;Writing

PROJECT_TITLE: Brain Networks for Addiction

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-L (02)]


NIH_SPENDING_CATS: Biomedical Imaging

ORG_CITY: CULVER CITY

ORG_NAME: WORLD MOLECULAR IMAGING SOCIETY

PHR: Narrative Molecular Imaging is making important breakthroughs in understanding life-threatening diseases. The World Molecular Imaging Congress (WMIC) provides a unique platform where members of several disciplines essential for the field of molecular imaging meet, learn, present, and discuss, the latest advances in the field. The goal of this R13 is to obtain specific funds to support the attendance of students at the graduate and postdoctoral levels, encouraging women, underrepresented minorities and persons with disabilities, to attend the annual WMIC in Montreal, Canada on September 9 – September 13, 2024.

PI_NAMEs: MANNING, HENRY CHARLES (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Academia;Achievement;Area;Basic Science;Biological Process;Biology;Biomedical Engineering;Canada;Cardiology;Cardiovascular system;career development;Categories;Chemistry;Clinic;clinical care;clinical imaging;Clinical Research;clinical translation;Collaborations;Communicable Diseases;Communities;Congresses;cost;Coupled;Data Science;Dedications;Detection;Development;Disabled Persons;Discipline;Disease;doctoral student;Education;Educational workshop;Endocrinology;Engineering;Ensure;Equity;Event;Fostering;Funding;Goals;Government;graduate student;Growth;Healthcare;Hearing;Human Biology;human disease;Image;image guided therapy;Imaging technology;Immunology;Immunotherapy;improved;in vivo imaging;Industry;Infection;Inflammation;innovation;insight;instrumentation;Interest Group;International;Leadership;Learning;Life;Medical Research;Medicine;meetings;member;Mind;Mission;Modality;Molecular;Molecular Biology;molecular imaging;multidisciplinary;multimodality;Nanotechnology;Nature;Neurology;Neurosciences;next generation;Oncology;Operative Surgical Procedures;Optics;Outcome;Pathogenesis;Patient Care;Patient-Focused Outcomes;Physicians;Physics;Postdoctoral Fellow;preclinical imaging;prevent;programs;Research;Research Personnel;Rheumatology;Role;Science;Scientist;Secure;Societies;Students;symposium;Systemic disease;Technology;theranostics;tool;Training;Translational Research;translational scientist;Travel;Trustees;Underrepresented Minority;Underrepresented Populations;Woman;Work;working group

PROJECT_TITLE: 2024 World Molecular Imaging Congress (WMIC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-E (M1)]


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Public Health Relevance Statement Meiosis is a specialized set of cell divisions that generate male (sperm) and female (egg) gametes. In females, meiosis is associated with high rates of chromosome segregation errors, which lead to miscarriage, infertility, and developmental disorders such as Down’s syndrome. This project uses mouse oocytes as a model system to understand the basic molecular mechanisms that regulate female meiosis, thereby shedding a light on why this process is notoriously error prone.

PI_NAMEs: BALBOULA, AHMED  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TITLE: Mechanisms underpinning meiotic spindle formation and behavior


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE Premiere technologies and interdisciplinary training opportunities available to a new generation of researchers in new and emerging aging research models to advance the field. The need for new technologies to better support and study emerging research models in the laboratory and/or the clinic directly is of great need. Our proposal will acquire the newest cellular metabolism technology to study these models across hierarchical levels at the highest sensitivity and resolution.

PI_NAMEs: COHEN, PINCHAS ;CURRAN, SEAN P;LITHGOW, GORDON J;VERDIN, ERIC M. (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: 10 year old;Administrative Supplement;age-related disease;Aging;aging related;Biological;Biology of Aging;California;Cell Count;Cells;Clinic;Communities;design;Faculty;Funding Opportunities;Generations;Genus Hippocampus;Gerontology;Geroscience;Geroscientist;Hand;Image;improved;instrument;Laboratories;Licensing;Measurement;Measures;Metabolism;Methodology;Mitochondria;Modeling;Molecular;new technology;Organ;Organoids;Reagent;Research;Research Personnel;Research Support;Research Training;Resolution;Resources;Sampling;Schools;Services;Shock;Study models;Technology;Tissues;tool;training opportunity;Training Support;United States;Universities;usability

PROJECT_TITLE: The University of Southern California and Buck Institute Nathan Shock Center


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative We seek to understand how parents transmit their anxiety-related thinking patterns to their children. Data from this project will directly inform future studies testing parent-focused treatments for child anxiety. The long-term goal is to improve mental health and functioning in both children and their parents.

PI_NAMEs: ELIAS, COURTNEY BEARD (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: Address;Age;Anxiety;Anxiety Disorders;anxiety symptoms;anxiety treatment;anxious;Award;Behavioral;Black race;Cellular Phone;Child;Child Rearing;Cognitive;Communities;coping;Data;design;Distal;Ecological momentary assessment;Educational process of instructing;ethnic identity;experience;Feedback;Future;Gender;Goals;Health Services Accessibility;improved;Indigenous;intergenerational;Intervention;Interview;Knowledge;life span;Measures;Mental disorders;mental function;Mental Health;Methodology;Modeling;National Institute of Mental Health;novel;Observational Study;Outcome;parent grant;parental role;Parents;Participant;Patient Self-Report;Pattern;people of color;personalized intervention;personalized medicine;Preparation;psychologic;Race;racial identity;Randomized;resilience;response;Risk Factors;Self Assessment;smartphone application;Socialization;Speech;Strategic Planning;Stress;Testing;Theoretical model;theories;Thinking;Time;Translating;transmission process;United States;Visit;Work

PROJECT_TITLE: Parent interpretation bias as a key mechanism of intergenerational transmission of anxiety

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Natural Products

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project Narrative  Our study will investigate the structure and function of emerging PLP-dependent enzymes, discover new PLP-dependent enzymes through genome mining, and elucidate the natural product biosynthetic pathways involving PLP-dependent enzymes with potential novel functions. Our work will not only increase our knowledge of PLP enzymology, but also expand the biocatalytic toolbox for the biocatalytic synthesis of pharmaceutically important noncanonical amino acid building blocks.

PI_NAMEs: HAI, YANG  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Amines;Amino Acids;aminoacid biosynthesis;bioactive natural products;Biology;Carbon;Cell Physiology;Chemicals;Complex;Data;Enzymatic Biochemistry;Enzymes;Family;frontier;Funding;Genome;Goals;Investigation;Knowledge;Laboratories;Metabolism;Mining;Natural Products;Nature;non-Native;novel;parent grant;Pathway interactions;Pharmacologic Substance;Play;programs;Research;Role;Specificity;Structure;Substrate Specificity;Therapeutic;tool;Work

PROJECT_TITLE: Understanding the specificity and non-native catalytic activity of PLP-dependent enzymes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Human cytomegalovirus (HCMV) infection causes severe disease in immunocompromised individuals and is a leading cause of congenital disabilities. Prior research on HCMV-mediated metabolic remodeling were completed in non-physiological, high nutrient culture media with a focus on identifying optimal virus production. The proposed studies will identify how altering nutrients to better recapitulate infection in the human body impacts nutrient utilization and flow during HCMV replication

PI_NAMEs: MOKRY, REBEKAH L (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Address;Amino Acids;Carbon;Cell Culture Techniques;Cells;Citric Acid Cycle;Coenzyme A;Compensation;congenital infection;Culture Media;Cytomegalovirus;Cytomegalovirus Infections;Data;deprivation;Development;Developmental Disabilities;disability;Disease;Disease Progression;Environment;Fatty Acids;flexibility;Glucose;glucose uptake;Glutamine;Herpesviridae;Human;Human body;human model;Immunocompromised Host;Individual;Infection;insight;Investigation;Knowledge;Lipids;Mediating;Membrane;Metabolic;Metabolic Control;Metabolism;Modeling;Molecular;Nucleotides;Nutrient;Oxaloacetates;Physiological;Process;Production;Pyruvate;Regulation;Research;response;Role;Route;Source;Therapeutic;Time;tissue tropism;uptake;Viral;Viral Genome;Viral Proteins;viral rescue;Virus;Virus Replication;Work

PROJECT_TITLE: Impact of diverse nutrient environment on viral replication and metabolite flow in human cytomegalovirus infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-S(20)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma is one of the deadliest solid malignancies, with well-defined transcriptomic subtypes and amino acid dependencies. The study proposed here offers an innovative approach to investigate transfer RNAs as regulators of these phenotypes and robust molecular markers of disease progression. These factors, along with its capacity to elucidate broader mechanisms of cancer biology, underlie the proposal’s significance.

PI_NAMEs: KAWALERSKI, RYAN  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Academic Medical Centers;Affect;amino acid metabolism;Amino Acids;Anticodon;Archives;Basic Science;biobank;Biochemical;Biological;Biological Markers;Biology;Cancer Biology;career development;Cell Line;Cell Physiology;Cell Proliferation;Cell Survival;cell type;Cells;Cellular biology;Chemicals;chemoradiation;Chemoresistance;ChIP-seq;Classification;Clinical;clinical decision-making;clinical practice;Clinical Sciences;Codon Nucleotides;cohort;Colorectal Neoplasms;Couples;Cox Proportional Hazards Models;Cysteine;Data;Data Set;Dependence;deprivation;Development;Diagnosis;Disease;Disease Management;Disease Progression;disorder subtype;Doctor of Philosophy;Epithelium;Exhibits;experimental study;Fostering;Gene Targeting;Genes;Genetic Transcription;Half-Life;High-Throughput Nucleotide Sequencing;Histologic;Histology;Human;In Situ Hybridization;In Vitro;innovation;Investigation;Knock-out;Label;Lead;Link;Literature;Logistics;Lung;Maintenance;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;Medical;Messenger RNA;Metabolic;Metastatic Neoplasm to the Lung;Methods;Modality;Modeling;Modification;Molecular Disease;molecular marker;molecular subtypes;mRNA Decay;mRNA Stability;Nature;Neoplasm Metastasis;neoplastic cell;Normal Cell;Normal tissue morphology;novel;novel marker;Nucleotides;Nutrient availability;Oncogenic;Outcome;Pancreatic Adenocarcinoma;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathogenesis;patient prognosis;Patients;pharmacologic;Phenotype;Physicians;Pilot Projects;pressure;Production;Prognosis;prognostic;programs;Proteins;Regulation;Regulator Genes;Reporting;Research;Research Personnel;Ribosomes;RNA;RNA Polymerase III;Role;Sampling;Scientist;screening;Severity of illness;Site;skills;Solid;Structure;Survival Rate;Survivors;tissue culture;Training;Transcript;transcriptome;transcriptomics;Transfer RNA;Transfer RNA Aminoacylation;Translations;tumor;Tumor stage;tumorigenic;Untranslated RNA;Validation;Work

PROJECT_TITLE: Investigating tRNA biology as a prognostic and oncogenic feature in pancreatic adenocarcinoma


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Nashville

ORG_DEPT: NEUROSCIENCES

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE This proposal aims to understand the contributions of auditory and visual signals in both neural and behavioral responses to audiovisual motion under optimal and suboptimal perceptual conditions. Its findings would provide foundational knowledge critical for efforts to improve human and machine perception when sensory information is degraded, such as in certain cases of vision or hearing loss, or when navigating in darkness. Additionally, insights gained through this proposal would have exceptional translational value for future diagnostic and therapeutic work in clinical conditions increasingly symptomized by (multi)sensory dysfunction (e.g., autism, schizophrenia, and attention deficit hyperactivity disorder).

PI_NAMEs: SCHOENHAUT, ADRIANA  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Algorithms;Anatomy;Anesthesia procedures;Animals;Area;area MST;Attention deficit hyperactivity disorder;Auditory;autism spectrum disorder;Automobile Driving;Behavior;Behavioral;Behavioral Model;Behavioral Paradigm;behavioral response;Binding;Blindness;Brain;Clinical;Complex;Cues;Darkness;Diagnostic;Discrimination;Effectiveness;Environment;Event;experimental study;extrastriate visual cortex;Functional disorder;Future;goal oriented behavior;hearing impairment;Human;human imaging;imaging study;improved;Individual;Individual Differences;insight;Knowledge;Link;loss of function;Macaca;Maps;Medial;Modality;Modeling;Motion;Motion Perception;multisensory;neglect;neural;neural correlate;nonhuman primate;Perception;Performance;Psychophysics;Pulvinar structure;Recording of previous events;response;Role;sample fixation;Schizophrenia;segregation;Sensory;sensory cortex;sensory integration;sensory stimulus;sensory system;Signal Transduction;sound;Source;Specific qualifier value;Stimulus;success;Symptoms;Task Performances;Technology;Therapeutic;Training;Virtual and Augmented reality;Visual;Visual Motion;Visual Pathways;Work

PROJECT_TITLE: Neural Correlates of Auditory, Visual, and Audiovisual Motion Perception in Macaque Extrastriate Cortex


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Rural Health

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Contact PD/PI: Brufsky, Adam M. Project Narrative The goal of the National Clinical Trials Network Lead Academic Participating Site at UPMC Hillman Cancer Center, is to increase our level of participation in conceptualization, development, activation, performance, and reporting on the late-phase clinical trials of the NRG Oncology, ECOG-ACRIN, and Alliance for Clinical Trials in Oncology Network Groups. Page 7 Project Narrative

PI_NAMEs: BRUFSKY, ADAM M (contact);KIRKWOOD, JOHN MUNN

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: American College of Radiology Imaging Network;Cancer Center;Clinical Research;Clinical Trials;Data;Development;Eastern Cooperative Oncology Group;Enrollment;Faculty;Genotype;Goals;improved;Lead;Leadership;member;Mentors;Minority;National Cancer Institute;National Clinical Trials Network;Oncology;parent project;participant enrollment;Performance;Phase;Positioning Attribute;Postdoctoral Fellow;Process;Radiation Oncology;rare cancer;Reporting;Research;Research Personnel;Rural;Site;skills;Special Population;Wages

PROJECT_TITLE: NCI NCTN-Network Lead Academic Participating Site at UPMC Hillman Cancer Center


ADMINISTERING_IC: TS

IC_NAME: AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY

ORG_CITY: SOLNA

ORG_COUNTRY: SWEDEN

ORG_FIPS: SW

ORG_NAME: KAROLINSKA INSTITUTE

PHR: Project narrative Undisputedly, ALS is one of the worst diagnoses for doctors to give and for patients to receive, due to its rapid progression and the current lack of therapeutic options. Identification of potential non-genetic risk factors for ALS, especially the modifiable ones, is therefore of paramount importance in providing new knowledge for disease prevention among high-risk individuals and identifying novel therapeutic targets. Hence, this project aims to use high-quality epidemiological research resources in Sweden, in combination with state-of-the-art molecular technologies and data science, to identify and evaluate air pollution, alone or jointly with infections, as a potential risk and prognostic factor for ALS, focusing on characterizing how and why air pollution could be associated with ALS and contribute to the etiology, progression, and pathophysiology of ALS in humans.

PI_NAMEs: FANG, FANG  (contact)

PROJECT_TITLE: RFA-TS-24-010: Ambient Air Pollution as a Potential Risk Factor for ALS - Using a Multiomics Approach in a High-Quality Epidemiologic Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZTS1 TQD (10)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biotechnology;Brain Disorders;Dementia;Dystonia;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Niemann-Pick disease type C1 (NPC1 disease) is a hereditary disorder characterized by the lysosomal storage of cholesterol and sphingolipids, and clinical signs of progressive cerebellar ataxia, dementia, vertical supranuclear gaze palsy, dysphagia, and early death. Despite the identification of causative mutations and a partial understanding of the function of the lysosomal membrane-bound NPC1 protein, there are no FDA- approved therapies for NPC1 disease. This study will be the first to develop gene therapy approaches that will allow widespread correction of NPC1-associated disease in the brain of a large animal model and will provide proof of concept for advancement of this strategy to the clinics.

PI_NAMEs: VITE, CHARLES H (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: adeno-associated viral vector;Adverse effects;Affect;Animal Model;Ataxia;Basal Ganglia;Binding;Binding Proteins;Biochemical;Brain;Brain Diseases;brain size;Brain Stem;causal variant;Cell Death;Cell Survival;Central Nervous System Diseases;Cerebellar Ataxia;Cerebellar Diseases;Cerebellum;Cerebral cortex;Cessation of life;Cholesterol;cisterna magna;Clinic;Clinical;Clinical Trials;Collaborations;Combined Modality Therapy;Complementary DNA;Cyclodextrins;Data;Deglutition Disorders;Dementia;Disease;Dose Limiting;Dystonia;efficacy clinical trial;efficacy evaluation;Engineering;Evaluation;Family Felidae;FDA approved;Felis catus;Gangliosides;gaze palsy;gene therapy;Genetic Diseases;Hereditary Disease;Histologic;hydroxypropyl-beta-cyclodextrin;Injections;Intracarotid;Life;Mediating;Membrane;Methods;Modeling;Mus;Niemann-Pick Diseases;nonhuman primate;novel;NPC1 gene;Other Genetics;ototoxicity;Pathology;Patients;pre-clinical;prevent;protein expression;Proteins;Purkinje Cells;Reporter Genes;Reproducibility;Research Personnel;Route;Safety;Serotyping;Sphingolipids;Spinocerebellar Ataxias;Testing;Time;Transgenes;Translating;vector;Viral Vector

PROJECT_TITLE: Intracerebroventricular cyclodextrin and AAV-mediated gene therapy forglobal CNS disease correction in feline NPC1 disease

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA AGRICULTURAL AND MECHANICAL UNIV

PHR: Public Health Impact: Florida A&M University proposes establishing the RCMI Center in collaboration and partnerships with community-based organizations to address minority health and health disparities research. The center will enhance FAMU’s research capacity, increase the number of minority research investigators, promote minority health, and aid in the reduction of health disparities.

PI_NAMEs: SOLIMAN, KARAM F.A. (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Achievement;Address;African American;Area;Artificial Intelligence;artificial intelligence algorithm;Awareness;Behavioral;Behavioral Research;Biomedical Research;Breast Cancer therapy;Cancer Biology;career;career development;Cervical Cancer Screening;Clinic;Collaborations;Communities;community engagement;community organizations;Competence;Comprehensive Cancer Center;Data;Detection;Development;Disparity;Doctor of Philosophy;Education;Environment;Evaluation;Extramural Activities;Faculty;Florida;Funding;Goals;Grant;Health Disparities Research;health disparity;Health Promotion;improve minority health;improved;innovation;innovative technologies;Institution;Interdisciplinary Study;Intervention;Investigator-Initiated Research;Knowledge;meetings;Mentors;Minority;Minority Groups;minority health;minority health disparity;Minority Health Research;minority investigator;Minority-Serving Institution;Mission;novel strategies;novel therapeutics;Pain management;Pharmacologic Substance;Pilot Projects;Population;programs;Public Health;recruit;Reduce health disparities;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Proposals;Resources;Science;Scientific Inquiry;screening;Series;skills;Specialized Program of Research Excellence;success;Techniques;tool;Training;Underrepresented Populations;Universities;Vision

PROJECT_TITLE: FAMU Center for Health Disparities Research


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Address;Advisory Committees;Affect;anti-cancer research;Area;artificial intelligence algorithm;Basic Science;Behavioral;Behavioral Research;career;Clinic;Collaborations;Communities;community partnership;Comprehensive Cancer Center;Data;Development;Disease;Disparity population;Educational workshop;Effectiveness;Ensure;Environment;Evaluation;experience;Extramural Activities;Faculty;faculty support;Florida;Funding;Future;Goals;Health;Health Disparities Research;health disparity;improved;Institution;International;Knowledge;member;Mentors;Minority;Minority Groups;minority health;minority health disparity;Monitor;next generation;novel;Outcome;Program Evaluation;programs;racial health disparity;Reduce health disparities;Research;Research Activity;Research Personnel;Research Project Grants;Scientist;Services;skills;success;symposium;Techniques;Training;Universities;Work

PROJECT_TITLE: Administrative Core