ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Medicaid covers the majority of individuals who need opioid use disorder (OUD) treatment and disproportionately covers minoritized populations and those with socioeconomic risk factors. The Medicaid Outcomes Distributed Research Network (MODRN) has supported Medicaid agency efforts to improve OUD treatment by developing novel measures of treatment quality and examining effects of treatment quality on overdose. MODRN will now draw on robust university-state partnerships in 12 states and multistakeholder engagement to inform quality improvement initiatives and Medicaid policy through three integrated research projects aiming to: 1) develop provider-level OUD quality measures using Medicaid administrative data; 2) measure OUD patient-reported outcomes and examine associations with claims-based quality measures to guide quality and equity improvement, and 3) implement and examine the effectiveness of a practice-level quality improvement intervention for OUD.

PI_NAMEs: BARNES, ANDREW JAMES;DONOHUE, JULIE MARIE (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Accounting;barrier to care;behavioral health;beneficiary;Caring;Case Mixes;comparison group;Continuity of Patient Care;Data;Decision Making;Disparity;Effectiveness;effectiveness evaluation;Enrollment;Equity;Ethnic Origin;experience;Federally Qualified Health Center;Feedback;follow-up;Freedom;Goals;Grant;health equity;Healthcare;Housing;Improve Access;improved;Individual;Inequity;Infrastructure;Intervention;intervention effect;Learning;Managed Care;Measurement;Measures;Medicaid;medication for opioid use disorder;Methods;Minority Groups;Modality;Modeling;National Institute of Drug Abuse;novel;opioid treatment program;opioid use;opioid use disorder;Outcome;Outpatients;Overdose;patient engagement;Patient Outcomes Assessments;Patients;perceived discrimination;Pharmaceutical Preparations;Physicians;Policies;Policy Analysis;Policy Maker;Population;Process Measure;programs;Provider;provider factors;psychosocial;Quality of life;Quasi-experiment;Race;Reporting;Research;Research Project Grants;residential segregation;response;Risk Factors;Sampling;Security;social deprivation;socioeconomics;Subgroup;substance use treatment;Surveys;System;Testing;treatment effect;Universities;Variant

PROJECT_TITLE: Improving quality and equity of opioid use disorder treatment using a multi-state Medicaid research network


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE This project investigates the mechanism of neurologic toxicity in chimeric antigen receptor (CAR) T cell therapy, a novel and highly effective cancer immunotherapy that unfortunately has frequent side effects of cognitive disturbances, seizures, or even fatal brain swelling. We have found in a mouse model that white blood cells obstruct capillaries in the brain during neurotoxicity. We will now determine whether dislodging these cells from the vessels can prevent neurotoxicity, whether this mechanism can be recapitulated in a human in vitro brain microvessel model, and how the signaling properties of CAR T cells contribute to toxicity and cell-cell adhesion.

PI_NAMEs: GUST, JULIANE  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: 3-Dimensional;Ablation;Acute;Address;Adhesions;Affect;Aftercare;Animal Model;Antibodies;Basic Science;Behavior;Behavioral;Biology;Biomedical Engineering;Blood capillaries;Blood Vessels;Brain;Brain Death;brain dysfunction;Brain Edema;brain endothelial cell;cancer cell;cancer immunotherapy;Capillary Endothelial Cell;CAR T cell therapy;CD19 gene;Cell Adhesion Molecules;cell type;Cell-Cell Adhesion;Cells;Cellular immunotherapy;Central Nervous System;cerebral capillary;Cerebral Edema;cerebral microvasculature;Child;Childhood;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;cohort;Collaborations;Collagen;Coma;cytokine;cytokine release syndrome;Delirium;Development;Dose;Endothelium;Engineering;Epitopes;Equilibrium;experience;experimental study;Flow Cytometry;Gene Expression Profiling;Genetic;genetically modified cells;Hematologic Neoplasms;Hemorrhage;high risk;Human;Human Engineering;human model;Hydrogels;Hypoxia;Image;Immune system;Immunocompetent;immunological synapse;Immunoprecipitation;Impaired cognition;Impairment;In Vitro;in vitro Model;in vivo;in vivo imaging;in vivo two-photon imaging;Inflammatory;Infusion procedures;Injury;innovation;Integrin Binding;Integrins;Interdisciplinary Study;International;Investigation;knock-down;leukemia/lymphoma;Leukocytes;Link;Malignant - descriptor;Malignant Neoplasms;manufacture;Measures;Mediating;Medical;Modality;Modeling;Molecular;Motor;mouse model;Mus;natalizumab;Neurologic;Neuronal Dysfunction;Neurosciences;neurotoxicity;neurovascular unit;novel;Oncology;Pathway Analysis;Patients;Perfusion;Pericytes;peripheral blood;Phenotype;Plasma;Positioning Attribute;preclinical safety;prevent;preventive intervention;Property;protein protein interaction;Proteins;Protocols documentation;Receptor Activation;receptor binding;Risk;Risk Factors;Safety;Sampling;Seizures;side effect;Signal Induction;Signal Transduction;Small Interfering RNA;Stimulus;systemic inflammatory response;T-Cell Proliferation;T-Cell Receptor Therapy;T-Lymphocyte;Techniques;Testing;Therapeutic Intervention;Toxic effect;Transgenic Organisms;Translating;tumor;Work

PROJECT_TITLE: Endothelial-Leukocyte Adhesion in CAR T Cell Treatment Associated Neurotoxicity

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Cancer

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PI_NAMEs: ASHWORTH, ALAN  (contact)

PROJECT_TERMS: Area;Award;Cancer Center Support Grant;career;Clinical Investigator;Clinical Trials;Development;Dissemination and Implementation;early-career faculty;Ensure;Evaluation;faculty support;Funding;Goals;Grant;Investments;Leadership;Link;Monitor;Nursing Faculty;Pilot Projects;Process;programs;Publications;Research;Research Personnel;Research Support;Source;Strategic Planning;Time;Translations;Wages

PROJECT_TITLE: Developmental Funds

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


PI_NAMEs: SMALL, ERIC J (contact)

PROJECT_TITLE: Shared Resource Management


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: BOSTON

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: PROJECT NARRATIVE Over the past decade, pet dogs with spontaneous disease have been progressively integrated into the preclinical drug and device testing paradigm with the goal of reducing high rates of translational failure that hamper therapeutic advancement. However, precise application and incorporation of data generated from this model system into human health practices remains a significant barrier. Studies outlined in this proposal will leverage two disease settings in pet dogs (cancer and cachexia from heart failure) to develop, optimize, and credential approaches for early detection and intervention, while simultaneously improving and expanding methodologies for effectively connecting information across both species.

PI_NAMEs: LONDON, CHERYL A (contact)

PROGRAM_OFFICER_NAME: CURE, PABLO

PROJECT_TERMS: Address;Adopted;Affect;Aging;Animal Disease Models;Animals;Biological;Biological Assay;Biological Models;Biomedical Engineering;Blood;Cachexia;Cancer Cachexia;Cancer Relapse;Canis familiaris;cardiac cachexia;Caring;Clinical;Clinical Research;Clinical Trials;cohort;Combined Modality Therapy;comparative genomics;Credentialing;Data;Data Commons;data integration;data modeling;Data Set;design;Detection;detection method;Development;Devices;Diagnostic;diagnostic panel;differential expression;digital;Dimensions;Disease;Disease Progression;Drops;Drug Combinations;drug efficacy;Early Diagnosis;Early Intervention;efficacy evaluation;Elements;Enrollment;Ensure;Evaluation;exosome;Failure;Freedom;Funding;Future;Genetic Engineering;genetic manipulation;Genome;genomic data;Genomics;Goals;Health;Health Alliance;Health system;Heart failure;Hemangiosarcoma;Human;human data;human disease;IACUC;improved;individual patient;individualized medicine;Informatics;informatics infrastructure;informatics tool;Infrastructure;innovation;Intervention;liquid biopsy;Machine Learning;Malignant Neoplasms;Medical;Medicine;Methodology;Methods;MicroRNAs;middleware;Modeling;Monitor;multiple omics;Muscle;Muscular Atrophy;Nerve Degeneration;novel;novel strategies;Observational Study;Ontology;Outcome;Parents;patient variability;Patients;Performance;Pharmaceutical Preparations;Phenotype;Pilot Projects;Plasma;Play;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Process;Property;prospective;Publishing;Rapid screening;Recurrent disease;reference genome;Research;Research Infrastructure;Resources;Risk;Role;Sampling;Science;Scientific Advances and Accomplishments;Screening for cancer;Site;Specimen;standard of care;Standardization;Technology;Testing;Therapeutic;therapeutic evaluation;Time;timeline;tool;translation to humans;translational model;translational potential;treatment strategy;trial design;tumor progression;Ultrasonography;ultrasound;United States National Institutes of Health;Validation;Veterinary Medicine;Vocabulary;wasting;Work

PROJECT_TITLE: Optimizing integration of veterinary clinical research findings with human health systems to improve strategies for early detection and intervention


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Address;Advisory Committees;anti-cancer research;authority;Breast Oncology;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer immunotherapy;Clinical Sciences;clinical translation;community advisory board;community engagement;Data;design;disparity reduction;Doctor of Philosophy;Education;equity, diversity, and inclusion;Evaluation;Goals;Health;improved;Individual;Institution;Intervention;Joints;Laboratory Research;Leadership;Malignant Childhood Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medical;Medicine;meetings;member;Mission;molecular oncology;Neurologic Oncology;operation;outcome disparities;Output;Participant;Performance;Physicians;Population Sciences;programs;Research;Resource Sharing;Resources;Role;Services;Site;Strategic Planning;Structure;success;Translational Research;tumor immunology

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: ANDREADIS, CHARALAMBOS  (contact)

PROJECT_TERMS: Address;Affect;Age;anti-cancer research;Area;Cancer Center Support Grant;Catchment Area;Clinical;Clinical Data;Clinical Management;Clinical Protocols;Clinical Research;clinical training;clinical trial enrollment;Clinical Trials;Collaborations;community engagement;Community Outreach;Conduct Clinical Trials;Data;Data Aggregation;data management;demographics;Development;Disease;Disparity;Equity;Ethnic Origin;Gender;Goals;improved;Individual;Infrastructure;Institutional Review Boards;investigator training;Life Cycle Stages;life span;Maintenance;Malignant Neoplasms;Minority;Monitor;patient population;Patients;Population Heterogeneity;protocol development;Race;Reporting;Research;Research Activity;Research Personnel;Research Priority;research study;Research Support;Research Training;Safety;Site;success;Woman;Work

PROJECT_TITLE: Clinical Protocol and Data Management


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: COLUMBIA

ORG_NAME: SC STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: SC

PHR: Project Narrative The South Carolina Department of Agriculture (SCDA) has achieved full implementation and full conformance with all standards of the Manufactured Foods Regulatory Program Standards (MFRPS). Through this cooperative agreement, SCDA will continue to use systematic methods to maintain these achievements along with identifying and overcoming obstacles to maintain full conformance with the 2022 standards and ensure the citizens of South Carolina a safe and wholesome food supply. The South Carolina Food Safety Task Force provides food protection program coordination and information-exchange between industry, academia, state and federal regulators, and other state agencies at scheduled quarterly meetings. 1

PI_NAMEs: DORTON, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: ARESHENKO, NICOLA

PROJECT_TITLE: Continued Implementation and Maintenance of the Manufactured Foods Regulatory Program Standards and Food Protection Task Force by the South Carolina Department of Agriculture


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Hypertension;Maternal Health;Neurosciences;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative The Chronic Hypertension and Pregnancy (CHAP) trial recently led to new recommendations to use antihypertensive treatment for mild chronic hypertension (<160/105 mmHg) during pregnancy based on multiple salutary maternal and newborn outcomes. The CHAP Child Follow-up study now proposed will define the effects of prenatal antihypertensive treatment and superimposed preeclampsia on the neurodevelopment, growth and other cardio-metabolic outcomes of offspring. The results will define the long-term safety and benefits of the new guideline to treat mild chronic hypertension during pregnancy to a goal <140/90 mmHg and potentially lead to preventative strategies that will enhance the future health of children born to women with chronic hypertension.

PI_NAMEs: CHANDLER-LANEY, PAULA CATHERINE;NEWSOM, CASSANDRA R.;SZYCHOWSKI, JEFF M;TITA, ALAN THEVENET N. (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Address;adjudication;adverse outcome;Affect;Age;Age Years;Ancillary Study;Anti-Hypertensive Agents;authority;Birth Weight;Blood;Blood Pressure;blood pressure elevation;Body mass index;Cardiometabolic Disease;cardiometabolism;cardiorespiratory fitness;Cardiovascular system;Cerebral Palsy;Characteristics;Child;Child Health;Childhood;Chronic;Classification;cognitive function;Data;Desire for food;Diabetes Mellitus;Diet;Disease;Dose;Eating Behavior;Enrollment;Ethnic Origin;Fetal Growth Retardation;follow-up;Follow-Up Studies;Frequencies;Functional impairment;Funding;Future;Gestational Age;Glean;Goals;Growth;Guidelines;Health;high risk population;Household;Hypertension;hypertension treatment;Impaired cognition;Impairment;improved;Knowledge;Long-Term Effects;Low Birth Weight Infant;Measures;Mediator;Medical;Mothers;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;Neonatal;neonatal morbidity;Neonatal Mortality;neurodevelopment;Newborn Infant;Obesity;offspring;Outcome;Overweight;Participant;Patients;Perinatal;perinatal outcomes;Persons;Pharmacological Treatment;Physical activity;postnatal;Pre-Eclampsia;Predictive Factor;Pregnancy;Pregnancy Tests;Pregnant Women;Premature Birth;prenatal;Prevention strategy;primary outcome;Race;Randomized;randomized trial;Recommendation;Risk Factors;Safety;Site;Small for Gestational Age Infant;social;Specific qualifier value;Strategic Planning;Stress;synergism;Testing;treatment trial;Underweight;Visit;Woman;women's treatment

PROJECT_TITLE: Offspring Neurodevelopment and Growth after Early Antihypertensive Therapy OR Preeclampsia in Women with Chronic Hypertension and Pregnancy (CHAP Child).

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Sleep Research;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Opioid use disorder (OUD) is a treatable medical illness with three medications FDA approved for treatment. However, persons with OUD report significant sleep disturbance, even when treated with medications for opioid use disorder, leading to high rates of relapse. In this project, we will investigate a special set of photosensitive neurons in the retina as an underlying mechanism for circadian rhythm and sleep disturbance from opioid use and medications for OUD that could lead to novel intervention and improve treatment outcomes.

PI_NAMEs: CROPSEY, KAREN L (contact);GAMBLE, KAREN L

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: actigraphy;Acute;Affect;Agonist;antagonist;Arousal;Attenuated;awake;Behavior;Biological Markers;Brain;Buprenorphine;Cell Physiology;Chronic;chronic pain;circadian;Circadian Dysregulation;circadian regulation;Circadian Rhythms;cohort;craving;Darkness;Data;disorder control;Drowsiness;Drug Prescriptions;economic cost;Electrophysiology (science);Environment;Excessive Daytime Sleepiness;FDA approved;follow-up;ganglion cell;Genetic;health care service utilization;Human;illicit opioid;Impairment;improved;improvement on sleep;Income;individualized medicine;Intervention;Light;Lighting;Macaca mulatta;Mediating;Medical;medication for opioid use disorder;Melatonin;Methadone;Moods;mu opioid receptors;multidisciplinary;Naltrexone;neural;Neurons;non-opioid analgesic;novel;novel marker;Opioid;Opioid agonist;Opioid Antagonist;opioid overdose;opioid use;opioid use disorder;opioid user;Outcome;overdose death;Participant;Pathway interactions;Patients;Periodicity;Persons;Pharmaceutical Preparations;preclinical study;predicting response;prescription opioid;Productivity;Pupil;Pupil light reflex;Quality of life;Recovery;Relapse;Reporting;response;Retina;Retinal Ganglion Cells;Rodent;Safety;Sampling;Selection for Treatments;selective expression;side effect;Sleep;Sleep Apnea Syndromes;Sleep Architecture;Sleep disturbances;Sleep Fragmentations;sleep regulation;Sleeplessness;Slow-Wave Sleep;societal costs;Testing;Treatment outcome;treatment response;United States;Ventilatory Depression;Vision;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Medications for opioid use disorder differentially modulate intrinsically photosensitive retinal ganglion cell function, sleep, and circadian rhythms: implications for treatment


NIH_SPENDING_CATS: Cancer;Social Determinants of Health

PI_NAMEs: CLARKE, JENNIFER LEIGH (contact)

PROJECT_TERMS: Address;Biometry;Cancer Burden;Cancer Center Support Grant;Catchment Area;Clinical Research;Clinical Trials;Discipline;Disease;Ensure;Feasibility Studies;Goals;Investigator-Initiated Research;Malignant Neoplasms;marginalized community;Monitor;Process;Protocols documentation;Research;Research Design;Research Priority;research study;Resources;Review Committee;Site;Strategic Planning;System;Time;underserved community

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ROCHESTER

ORG_NAME: PIRAEUS MEDICAL, INC.

ORG_STATE: MN

PHR: PROJECT NARRATIVE In this Phase II program, we will test the novel ‘wrist-to-brain’ system that provides optimal navigation characteristics to rapidly remove blood clots from arteries in patients suffering from severe stroke. Using a novel hyperthin liner system, our device will improve patient outcomes by allowing the use of the radial artery in the wrist rather than the femoral artery, a crucial capability in elderly patients who have hardened and tortuous arteries. The in vitro, cadaver, and animal testing in this grant will prove the effectiveness and safety of the device and provide all data needed to submit for FDA clearance of this physician-driven innovation.

PI_NAMEs: HUTAR, JARED  (contact);KALLMES, DAVID F

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: Acute;Address;Adoption;Anatomy;Animal Testing;Animals;aortic arch;Area;arterial tortuosity;Arteries;artery occlusion;aspirate;Automobile Driving;Blood coagulation;Blood Vessels;Brain;Bypass;Cadaver;Cardiology;Catheters;Cause of Death;Cerebrovascular system;Characteristics;Circulation;Clinical;Coagulation Process;commercialization;Coronary;Coronary Circulation;Data;Descending aorta;design verification;Device Designs;Devices;Diameter;Dilator;disability;Distal;Effectiveness;Elderly;Endothelium;Evolution;experience;Extravasation;Face;Failure;Family suidae;femoral artery;Femur;Funding;Future;Goals;Grant;Hematoma;Hemorrhage;improved;improved outcome;In Vitro;in vitro testing;in vivo;Inguinal region;Injections;innovation;International;Intervention;Interview;Ischemic Stroke;Leadership;Length;Location;Marketing;Mechanics;Medical;men;Modernization;Neurological outcome;Neurons;novel;older patient;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Performance;Perfusion;Phase;Physicians;Preclinical Testing;Procedures;programs;Radial;radial artery;randomized trial;Resistance;revascularization;Risk;Role;Route;Rupture;Safety;Sales;Site;Small Business Innovation Research Grant;Speed;standard care;Stents;Stroke;stroke patient;success;Suction;System;Testing;Thick;Thinness;Thrombectomy;Torque;usability;Vacuum;Validation;vascular bed;Vasospasm;Woman;Work;Wrist

PROJECT_TITLE: Enabling rapid and effective stroke thrombectomy procedures from a Transradial approach: Combining introducer sheath, guide catheter, and distal access catheter into a single device.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-W(12)B]


NIH_SPENDING_CATS: Aging;Biotechnology;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: San Antonio

ORG_NAME: NEONEURON, LLC

ORG_STATE: TX

PHR: Project Narrative: Parkinson’s disease (PD) is a progressive neurodegenerative disease that is currently incurable and with significant unmet medical needs. In this application  NeoNeuron LLC proposes to conduct U.S. Food and Drug Administration (FDA) requested IND-enabling studies to develop promising cell therapy approach for PD. NeoNeuron met with the FDA and received comments and recommendations to determine the optimal dose level range for the intended cellular product, DA neurons, in an immunocompromised rat model of PD. The proposed study is designed to demonstrate levels of DA neuron engraftment and survival for a 6-month duration and robust evidence of the durable effects of the intended product in vivo.

PI_NAMEs: DAADI, MARCEL  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: Address;Adult;Agreement;Amphetamines;Anatomy;Animal Disease Models;Animals;Area;Axon;Biomedical Research;Blood Cells;Body Weight;Bradykinesia;Brain;Cause of Death;Cell Survival;Cell Therapy;Cell Transplantation;cell type;Cells;Chemistry;Clinical;clinical practice;Clinical Protocols;Clinical Research;Cognitive;Cognitive deficits;cognitive function;cognitive training;commercialization;comparison control;Control Groups;Corpus striatum structure;cost estimate;design;Development;Devices;Disease;Disease Management;disease model;Dopamine;Dopaminergic Cell;dopaminergic neuron;Dose;Educational Intervention;Engraftment;Ethics;fetal;Forelimb;Good Manufacturing Process;graft function;Graft Survival;image guided;Immunocompromised Host;improved;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Injections;insight;Intellectual Property;Investigational Drugs;Lesion;Licensing;Location;manufacture;Medical;Methodology;Methods;Midbrain structure;Modeling;Molecular;Motor;motor function improvement;MPTP Poisoning;nerve stem cell;nerve supply;Nervous System Disorder;Neurodegenerative Disorders;Neurosciences;neurotransmission;non-motor symptom;nonhuman primate;Oxidopamine;Parkinson Disease;pars compacta;Patients;Persons;Pharmaceutical Preparations;Phase;Pluripotent Stem Cells;preclinical study;Preparation;Procedures;product development;Production;Proliferating;Property;Published Comment;putamen;Rattus;Recommendation;Recovery of Function;Regimen;Research Institute;response;restoration;Rotation;Safety;safety assessment;side effect;Skin;Sleep disturbances;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Somatic Cell;Source;stem;stem cell technology;stem cell therapy;Step Tests;Substantia nigra structure;symptom treatment;Symptoms;Technology;Testing;Texas;Therapeutic;Time;Tissues;Toxicology;transcriptomic profiling;transcriptomics;Transplantation;transplantation therapy;Tremor;United States Food and Drug Administration;Universities

PROJECT_TITLE: IND-enabling studies for cell therapy in Parkinson's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative Control of the transcription machinery is vital for human cells to determine their fate and is particularly important for brain cells (neurons and glia) to maintain cell fitness. Toward an understanding of this process, we have elucidated biochemical and structural properties of factors associated with the Integrator complex, which regulates transcription and is frequently mutated in neurological disorders. We will leverage this preliminary information and propose a multi-faceted approach that will generate knowledge with the potential to enhance health, lengthen life, and reduce disability.

PI_NAMEs: PROSCHEL, CHRISTOPH ;TONG, LIANG ;WAGNER, ERIC J (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Active Sites;Address;Architecture;Auxins;Binding;Binding Proteins;Biochemical;Biochemistry;Brain;brain cell;Brain Diseases;C-terminal;Cell Line;cell type;Cells;Cerebellar Ataxia;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cryoelectron Microscopy;Cytoplasm;Cytoplasmic Protein;Cytoplasmic Structures;Defect;disability;Endoribonucleases;experimental study;fitness;functional genomics;Galloway syndrome;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;Genetic Transcription;genetic variant;genome editing;Health;Human;Human Development;human embryonic stem cell;Human Engineering;Knowledge;Laboratories;Licensing;Life;Measures;Mediating;Modeling;Molecular;Muscle hypotonia;mutant;Mutate;Mutation;Neonatal;Nervous System Disorder;Neurobiology;neurodevelopment;Neuroglia;Neurologic;Neurologic Symptoms;Neuronal Dysfunction;Neurons;novel;Nuclear;Null Lymphocytes;Organoids;Pathogenicity;Patients;Pattern;Process;promoter;Property;Proteins;Psychomotor Impairments;Research;Resolution;RNA Polymerase II;Role;Seizures;single-cell RNA sequencing;small molecule inhibitor;stem cells;structural biology;Structure;Syndrome;synergism;System;Testing;Transcript;Transcriptional Regulation;transcriptome sequencing;Untranslated RNA;Variant

PROJECT_TITLE: Probing the Role of Integrator in Neuronal Function

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

PHR: PROJECT NARRATIVE A well-known consequence of aging is a decline in physical function. These declines are a manifestation of the cumulative effects of molecular- and cellular-level impairment that have been stratified into Hallmarks of Aging. Here, we will employ a novel bioinformatic strategy to evaluate the effect of aging on biomolecular communication across the Hallmarks. Next, we will evaluate the physiological relevance of our findings through a series of experimental studies in mice across the lifespan. Ultimately, we anticipate this framework can be used to: 1) predict an individual’s biological age and/or likelihood for future pathology and 2) develop strategies to re-organize, re-wire, and/or reprogram gene networks to preserve a more youthful phenotype.

PI_NAMEs: AMBROSIO, FABRISIA  (contact);MUGLER, ANDREW

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Affect;Age;age effect;age related;aged;Aging;Automobile Driving;Back;Binding;Bioinformatics;Biological;biological age;Biological Markers;Cell Physiology;Cells;Code;Collection;Communication;comparative;Complex;Computer Analysis;Computer Systems;Data;Dependence;Deterioration;Disease;drivers of aging;Entropy;experimental group;experimental study;Feedback;Female;Functional disorder;Future;Gene Expression;gene network;Genes;Genetic;genetic information;genetic manipulation;Goals;hallmarks of aging;Health;Human;Image;Impairment;in vivo;Individual;Influentials;Information Theory;innovation;Intervention;Investigation;Knock-out;Life;life span;Link;loss of function;Maintenance;male;Maps;Measures;Methodology;middle age;Modeling;Molecular;molecular dynamics;Mus;Muscle;muscle aging;Muscle Fibers;Muscle function;Nature;Noise;novel;operation;Organism;Outcome;overexpression;Pathology;Pattern;Phenotype;Physical Function;Physics;Physiological;Population;preservation;Process;programs;Property;Proteins;Rattus;regeneration potential;Science;Series;sex;Signal Pathway;single-cell RNA sequencing;Skeletal Muscle;small hairpin RNA;stem cells;success;System;Testing;Time;Tissues;tool;transcription factor;transcription regulatory network;transcriptome sequencing;Work

PROJECT_TITLE: Genetic information flow in the Hallmarks of Aging: from system-level analytics to mechanistic interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-Z(52)]


NIH_SPENDING_CATS: Aging;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Peripheral artery disease (PAD) is a common cardiovascular disorder that often goes undiagnosed, leading to excess morbidity and mortality, which disparately affects females, racial/ethnic minorities and those in lower socioeconomic groups. We have developed an automated approach to detecting PAD prior to clinician diagnosis using electronic health record data and machine learning algorithms. We propose to validate and strengthen our model by assessing for, and addressing subgroup bias, co-developing clinical care pathways with stakeholders to maximize model utility and provider adoption, and evaluating the effect of an automated PAD screening tool on diagnosis rates and initiation of life-saving medical and behavioral treatments.

PI_NAMEs: ROSS, ELSIE GYANG (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Address;Adoption;Adult;Affect;Algorithms;American;Area Under Curve;Artificial Intelligence;artificial intelligence model;Atherosclerosis;Awareness;Behavior Therapy;Black Populations;Blood Platelets;Calibration;Cardiovascular Diseases;Cardiovascular system;Caring;Clinical;clinical care;Clinical effectiveness;clinical research site;Clinical Trials Design;Cluster randomized trial;cohort;Communities;Data;Data Set;Decision Analysis;demographics;design;Detection;Diagnosis;digital health;Disabling;Discrimination;Disease;disease diagnosis;disease disparity;disparities in morbidity;disparities in women;Disparity in diagnosis;disparity reduction;Early Diagnosis;Electronic Health Record;electronic health record system;Ensure;ethnic minority;Ethnic Origin;Evaluation;Event;evidence base;Exercise;Family;Female;flexibility;Fostering;Goals;Guidelines;Health;health care settings;health disparity;High Prevalence;improved;Individual;innovation;Institution;Intervention;Interview;Leg;Life;limb loss;Limb structure;Lipids;Lower Extremity;machine learning algorithm;Measures;Medical;Methods;Minority;Modeling;Morbidity - disease rate;mortality;mortality disparity;National Heart, Lung, and Blood Institute;novel;Outcome;Outpatients;Pathway interactions;patient population;Patients;Pattern;Performance;Peripheral arterial disease;personalized care;Pharmaceutical Preparations;Population;Population Heterogeneity;Primary Care;primary care setting;Process;prospective;Provider;provider adoption;Race;racial minority;Recommendation;Registries;Research;response;Risk;routine screening;rural dwellers;screening;Screening procedure;sex;Site;smoking cessation;socioeconomics;Subgroup;Symptoms;Technology;tool;trial design;United States Department of Veterans Affairs;Validation;Woman;Work

PROJECT_TITLE: Artificial Intelligence for early Detection of Peripheral Artery Disease (AID-PAD)

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE In this study, we will evaluate the use of the SAMURAI PICU (Situation Awareness incorporating MUltidisciplinary Teams Reduce Arrests In the PICU) bundle to improve early identification of high-risk patients, increase shared situation awareness, and support risk mitigation plans and thereby reduce pediatric in hospital cardiac arrest and improve patient safety. We will utilize a five-center pragmatic prospective Hybrid Type 1 effectiveness-implementation approach leveraging the existing infrastructure of Pediatric Resuscitation Quality Collaborative.

PI_NAMEs: DEWAN, MAYA L (contact)

PROGRAM_OFFICER_NAME: HAUGSTETTER, MONIKA

PROJECT_TITLE: SAMURAI PICU: Situation Awareness incorporating Multidisciplinary Teams Reduce Arrests In the Pediatric ICU

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Precision Medicine;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: NARRATIVE We will test the clinical validity of measuring sensitivity to endocrine therapy (SETER/PR index of gene expression) in archival primary breast cancer samples to predict whether a patient with hormone receptor-positive HER2-negative breast cancer will benefit from an additional 5 years of endocrine therapy. A CLIA-certified laboratory at MD Anderson Cancer Center will measure SETER/PR index in the primary tumor samples from NSABP B-42, a placebo controlled, randomized trial of 5 years extended letrozole treatment, versus placebo, for patients who had completed 5 years of a standard endocrine therapy. The primary analysis will test whether SETER/PR index values in the range 1.10 to 2.10 predicts longer breast cancer-free interval in the patients who received extended letrozole treatment, versus placebo treatment.

PI_NAMEs: SYMMANS, WILLIAM F (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: adjuvant endocrine therapy;Adjuvant Therapy;Biological Assay;breast cancer diagnosis;Cancer Center;Cancer Control;chemotherapy;CLIA certified;Clinical;Data;Disease-Free Survival;Distant;Endocrine;ERBB2 gene;ESR1 gene;Estrogen Receptors;Evaluation;Formalin;Gene Expression;Genes;Genetic Transcription;Genomics;hormone receptor-positive;hormone therapy;improved;indexing;Laboratories;Letrozole;Ligand Binding;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Measures;Molecular;molecular phenotype;molecular subtypes;National Surgical Adjuvant Breast and Bowel Project;Neoadjuvant Therapy;Nodal;Palliative Care;Paraffin Embedding;Pathologic;patient subsets;Patients;Performance;Pharmacodynamics;Placebos;Population;predictive test;Primary Neoplasm;Probability;Progesterone Receptors;Prognosis;prognostic;Prognostic Factor;prognostic index;Proliferating;Publications;Publishing;Randomized;randomized placebo controlled trial;receptor;Recurrence Score;Relapse;Reporting;Reproducibility;Residual state;response;Risk;RNA;Sampling;Science;secondary analysis;side effect;specific biomarkers;Tamoxifen;Testing;Tissue Sample;treatment arm;trial comparing;tumor;Validation;validation studies

PROJECT_TITLE: Evaluation of the Sensitivity to Endocrine Therapy (SET ER/PR) Assay to predict benefit from extended duration of adjuvant endocrine therapy in the NSABP B-42 trial


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Alzheimer’s disease (AD) is the most common cause of dementia affecting over 35 million people worldwide, and this number is expected to triple by 2050. This project examines the role of glycosphingolipids, a specialized class of membrane lipids that are highly abundant in the brain, in AD pathology. Findings of this study will provide important new insight into AD pathology and are likely to lead to novel therapeutic tools for AD treatment.

PI_NAMEs: GUO, ZHONGWU ;ZHAO, JINYING  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: abeta accumulation;Acceleration;Adhesions;Affect;age related neurodegeneration;Aging;aging brain;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease therapeutic;Amyloid beta-Protein;Autopsy;Binding;Biological Process;Brain;Brain Mapping;brain tissue;Carbohydrates;Cell membrane;Cells;Central Nervous System;Ceramides;Cessation of life;Clinical;cognitive ability;cohort;Collection;Communities;Coupled;Data;Dementia;design;Development;Diabetes Mellitus;Disease;DNA Methylation;Drosophila genus;epigenomics;extracellular;Extracellular Space;fly;Freezing;Functional disorder;G(M3) Ganglioside;Ganglioside GM1;Gangliosides;Genes;genetic manipulation;genome wide association study;Genomics;Glycosphingolipids;Goals;Histone Acetylation;Homologous Gene;Human;human tissue;hydrophilicity;Hydrophobicity;Impaired cognition;in vivo;innovation;innovative technologies;insight;Knockout Mice;Knowledge;Lipids;Malignant Neoplasms;Membrane Lipids;Memory;Meta-Analysis;Metabolic Diseases;Metabolism;Methods;MicroRNAs;Motor;multiple omics;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuropathology;new technology;new therapeutic target;novel;novel therapeutics;older adult;Parkinson Disease;Pathologic;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Pilot Projects;Play;Polysaccharides;Prefrontal Cortex;progressive neurodegeneration;protein transport;Proteomics;Rat Transgene;religious order study;response;Role;Sampling;Senile Plaques;Sialic Acids;Signal Transduction;Structure;Systems Biology;tau Proteins;Techniques;Testing;Tissue Sample;tool;transcriptome sequencing;transcriptomics;Validation;Vertebral column;Work;β-amyloid burden

PROJECT_TITLE: Brain glycosphingolipids and Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Obesity;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: The proposed research will examine primary care physicians’ attitudes and beliefs about genetic causes of obesity in Black and White patients, as well as perceptions among Black and White adults with obesity of physicians who endorse genetic explanations of obesity, using a cross- sectional survey, experimental social science methodology, and qualitative focus-groups. The results will inform strategies for combatting misguided notions of genetic differences between racial groups as the basis for obesity-related health disparities and for ensuring that the integration of genetics into healthcare for patients with obesity does not harm members of minoritized groups who are already at the highest risk of obesity-related health problems.

PI_NAMEs: LEBOWITZ, MATTHEW  (contact);PEARL, REBECCA L;TUCKER, CAROLYN M

PROGRAM_OFFICER_NAME: KAUFMAN, DAVE J

PROJECT_TERMS: adult obesity;Affect;African American;American;Attitude;Behavior Therapy;Belief;Biological;Black American;black patient;Black race;black women;caucasian American;Chronic Disease;Clinical;clinical care;clinical decision-making;Clinical effectiveness;Cross-Sectional Studies;Data;Disease;Disparity;DNA;Economics;Educational process of instructing;Empathy;Ensure;environmental disparity;Ethics;ethnoracial disparity;experience;experimental study;Faith;Focus Groups;follow-up;Future;Genetic;Genetic Predisposition to Disease;Health;health disparity;Health Personnel;Healthcare;high risk;Impairment;improved;Individual;Intervention;Judgment;Knowledge;Lead;Learning;Mediating;Mediation;member;Mental disorders;Methodology;Minority Groups;mortality;obese patients;Obesity;obesity genetics;obesity risk;obesity treatment;Outcome;Participant;Patient Agents;Patient Care;patient prognosis;Patients;Perception;Persons;Physician-Patient Relations;Physicians;Prevalence;Primary Care Physician;primary care provider;prognostic;Provider;Quality of life;Race;racial bias;racial difference;racial disparity;racial health disparity;racial minority population;racial population;Reaction;Reading;Research;Respondent;response;Risk;Risk Factors;Role;Sampling;Shapes;social;social health determinants;Social Sciences;Stigmatization;Suggestion;Surveys;Testing;Treatment outcome;trend;United States;Woman

PROJECT_TITLE: GENETIC ATTRIBUTIONS AND RACIALIZED PERCEPTIONS OF OBESITY


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The Reproductive Scientist Development Program plan for career development serves as a model for postgraduate medical education and assures that some of the most promising young physician-investigators in the country will remain in academic investigative obstetrics and gynecology. A great majority of the highly diverse Scholars who have finished Phase II of the Program have dedicated themselves to research in the reproductive sciences and have developed major independent funding support, with many becoming division heads, department chairmen and/or deans at their top tier academic institutions. To date the productivity of RSDP scholars past and present has been outstanding, has contributed greatly to the reproductive sciences, and is a credit for the Program.

PI_NAMEs: SCHUST, DANNY J (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: Basic Science;career;career development;Cellular biology;Clinical;Dedications;Discipline of obstetrics;Doctor of Philosophy;Ensure;experience;Faculty;faculty mentor;Fellowship;Funding;Goals;Gynecologist;Gynecology;Individual;Institution;Laboratory Research;Medicine;member;Mentorship;Mission;Molecular Biology;multidisciplinary;National Institute of Child Health and Human Development;Phase;Physicians;Program Development;programs;Recording of previous events;reproductive;Reproductive Biology;Reproductive Medicine;Reproductive Sciences;Research;Research Support;Residencies;Science;Scientist;Supervision;Time;Wages


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Project Narrative In 2050, the population aged 65 and over is projected to be 84 million, almost double than in 2012, increasing the importance of preserving cognitive health and functional capacity. Adult hippocampal neurogenesis is necessary for memory and emotional regulation, and its function is dependent on vascularization and neuroplasticity. The current controversy regarding the extent to which the human hippocampus can generate new neurons warrants new approaches comparing amounts of adult neurogenesis, vascularization and neuroplasticity in normally aging people and Alzheimer’s Disease.

PI_NAMEs: BOLDRINI, MAURA  (contact)

PROJECT_TERMS: Activities of Daily Living;Adult;adult neurogenesis;Affect;Age;age effect;age related;age related changes;age related decline;aged;Aging;aging brain;aging related disease;Alzheimer's Disease;Alzheimer's disease brain;Anatomy;angiogenesis;Animals;Astrocytes;Autopsy;behavioral response;Blood capillaries;Blood Vessels;Brain;Brain Diseases;Brain region;brain tissue;Cd68;Cell Nucleus;Cells;Clinical assessments;clinical phenotype;Cognitive;Cognitive aging;cognitive function;Collection;Correlation Studies;Cytoplasm;Cytoplasmic Granules;Data;Dementia;Dendrites;dentate gyrus;design;Diagnosis;Disease Progression;DLG4 gene;early life adversity;Educational Status;emotion regulation;Endothelial Cells;entorhinal cortex;Exclusion Criteria;Female;Glial Differentiation;Glial Fibrillary Acidic Protein;gliogenesis;Golgi Apparatus;Health;Hippocampus;Human;human old age (65+);Immunofluorescence Immunologic;Immunohistochemistry;immunoreactivity;indexing;Interview;ITGAM gene;KDR gene;Learning;Length;Letters;Life;life span;Link;Long-Term Potentiation;male;Maps;Measures;Memory;Messenger RNA;Methodology;Methods;Microglia;migration;Molecular;molecular marker;Molecular Target;Morphology;multiple omics;Mus;National Institute of Mental Health;nerve stem cell;nestin protein;Neural Cell Adhesion Molecules;neurofilament;neurogenesis;Neuroglia;Neuronal Differentiation;Neuronal Plasticity;Neurons;neuropathology;new technology;Newborn Infant;newborn neuron;nonhuman primate;normal aging;novel strategies;older adult;Older Population;Oligodendroglia;Pathogenesis;pediatric trauma;Persons;Phase;Phenotype;Population;postsynaptic;preservation;Prevalence;Process;Proteins;Proteomics;psychologic;Psychosocial Stress;Questionnaires;Recording of previous events;Reporting;Research Personnel;RNA;Rodent;Severities;Severity of illness;sex;single nucleus RNA-sequencing;Specificity;spinophilin;Stains;stem cell differentiation;stem cell expansion;stem cells;Stress;Structure;Synapses;Synaptic plasticity;Techniques;Technology;Testing;tissue processing;Tissues;Toxicology;transcription factor;Universities;Vascular Endothelial Growth Factor Receptor-1;Vascularization;Vertebral column;Visualization;Western Blotting;XCL1 gene

PROJECT_TITLE: Comparison of normal aging with Alzheimer's Disease: cellular, synaptic, and vascular indices affecting brain plasticity and neurogenesis


ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE – OVERALL COMPONENT The long term goals of the CaRE2 center are to reduce cancer disparities in Black/African American and Hispanic/Latinx individuals, to train and increase the pool of 120 underrepresented Black/African American and Hispanic/Latinx scientists conducting health disparity research, to increase research capacity at an HBCU (FAMU), and to increase cancer disparity research at UF and USC-NCCC. The proposed two full projects and pilot project include investigators from the three institutions and will leverage on specimens collected across the partnership from Black/African American and Hispanic/Latinx, representing a wide range of subpopulations within these minority groups. Thus, our studies will reveal unprecedented findings about these two understudied minority populations, will be instrumental in transferring cutting edge and innovative technologies to FAMU, and will expand in a significant way the research focus at UF and USC-NCCC to address cancer health disparities in pancreas and lung cancers.

PI_NAMEs: HUGHES-HALBERT, CHANITA A.;REAMS, ROMONIA RENEE;REDDA, KINFE KEN;STERN, MARIANA C (contact);WILKIE, DIANA J

PROGRAM_OFFICER_NAME: BARFIELD-STEWARD, WHITNEY

PROJECT_TERMS: Address;Advocate;African;African American;American;anti-cancer research;Award;Back;Benchmarking;Bioinformatics;Biological;Biological Models;Biomedical Research;Black American;Black Populations;Black race;California;Cancer Center;Cancer Control;cancer health disparity;Cancer Model;Cancer Patient;cancer prevention;career development;Caribbean region;Caring;Catchment Area;Censuses;Central American;Communities;Community Outreach;community partnership;Complex;Comprehensive Cancer Center;Cultural Diversity;Development;Disparity;disparity reduction;Doctor of Philosophy;drug development;Education;education research;Educational Materials;Effectiveness;Evaluation;Extramural Activities;Florida;Fostering;Funding;genetic makeup;genome resource;Goals;Grant;Health;Health Disparities Research;health disparity populations;health equity;Heterogeneity;Hispanic;improved;improved outcome;Incidence;Individual;Infrastructure;innovation;innovative technologies;Institution;Latino;Latino Population;Latinx;Latinx population;Leadership;Location;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;member;Mentors;Methodology;Methods;Mexican Americans;Minority;minority communities;Minority Groups;minority patient;minority trainee;mortality;novel anticancer drug;Outcome;outreach;patient population;Pilot Projects;podcast;Population;Population Heterogeneity;Postbaccalaureate;Postdoctoral Fellow;Process;programs;Publications;Publishing;Reporting;repository;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Resource Sharing;Resources;Scientist;Series;social determinants;South American;Specimen;Students;success;Tissue Model;tool;Training;Training and Education;translational cancer research;Translational Research;Underrepresented Minority;Underrepresented Students;Underserved Population;understudied cancer;United States;Universities;University of Southern California Norris Cancer Center;US State;Use Effectiveness;Work

PROJECT_TITLE: 3/3 Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center


ADMINISTERING_IC: AA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Project Narrative Although research documents the concerning rates of alcohol-related problems (ARPs), including hazardous alcohol use and alcohol-related consequences, among Indigenous populations (including the Lakota people in present day South Dakota), we still know little about how to prevent these deleterious issues that devastate Indigenous communities. The proposed project aims to document and pilot evaluate a culturally grounded mentoring program for Lakota older adolescents and adults that seeks to prevent ARPs and promote holistic well-being via enhancing connection to Lakota culture, social connection, and healthy coping and life skills. The proposed project aligns with the Goals of the NIAAA to prevent and reduce ARPs using culturally appropriate approaches for at-risk groups.

PI_NAMEs: EDWARDS, KATIE M;GARDELLA, JOSEPH HIROYUKI (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: acceptability and feasibility;Accreditation;Address;Adolescent;Adult;alcohol abstinence;Alcohol abuse;alcohol prevention;alcohol related consequences;alcohol related problem;alcohol risk;alcohol use disorder;American Indian community;American Indian Population;American Indians;binge drinking;Cessation of life;community partners;coping;Coping Skills;Criminal Justice;Data;Decision Making;design;Distal;Documentation;Elderly;Emotional;Ethnic Population;Etiology;Evaluation;Evaluation Research;experience;Fostering;Future;Generations;Goals;guidebooks;healing;Health;Health Professional;Immersion;indigenous community;Individual;Injury;innovation;interest;intergenerational;Interview;Knowledge;Lead;Legal;Life;life span;Manuals;meetings;Mental Health;Mentors;Mentorship;National Institute on Alcohol Abuse and Alcoholism;Native-Born;older adult;Outcome;peer support;Perception;Personal Satisfaction;Persons;Populations at Risk;Preparation;prevent;primary outcome;Process;process evaluation;Professional counselor;programs;Psyche structure;psychoeducation;public health research;racial population;Recording of previous events;Recovery;recruit;Relapse;Reporting;Research;Research Personnel;response;Safety;Sampling;Self Efficacy;skills;skills training;sobriety;social;Social isolation;Social Problems;Source;South Dakota;Spirituality;Strategic Planning;stressor;Substance abuse problem;Surface;Surveys;System;Testing;Teton Sioux Indian;Therapeutic;Time;Trauma;Work

PROJECT_TITLE: Pilot evaluation of a Lakota-centered lifespan mentoring program to reduce alcohol related problems and promote holistic wellbeing

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: STERN, MARIANA C (contact)

PROJECT_TERMS: Address;African;African American;African Caribbean;anti-cancer research;Award;Benchmarking;Black race;California;Cancer Center;cancer health disparity;cancer prevention;Cancer Science;Career Mobility;Caring;Central American;Clinical Trials;Collaborations;Communication;Communities;Community Outreach;Comprehensive Cancer Center;Cuban American;Data;Development;Doctor of Philosophy;Education;Education and Outreach;education research;Educational Activities;Ensure;ethnic diversity;Evaluation;Event;Exhibits;Extramural Activities;Florida;Foundations;Funding;gender diverse;Goals;Grant;Growth;Health;Health Disparities Research;health equity;Hispanic;Human Resources;implementation strategy;improved;Individual;Infrastructure;Institution;interest;International;Intranet;Knowledge;Latina;Latino;Latinx population;Lead;Leadership;Link;Mexican;minority engagement;Minority Groups;minority scientist;Mission;Modeling;Monitor;Office of Administrative Management;Online Systems;Outcome;Prevention Research;Principal Investigator;Program Evaluation;programs;Publications;Puerto Rican;racial diversity;Research;Research Personnel;Research Project Grants;Resource Sharing;Scanning;Scientist;Series;sharing platform;South American;Strategic Planning;Structure;success;Supervision;symposium;Underrepresented Minority;United States National Institutes of Health;Universities;University of Southern California Norris Cancer Center;Vision;web site;webinar;Woman;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Down Syndrome Regression Disorder (DSRD) is a devastating condition that is being increasingly identified and is of growing interest in the Down syndrome (DS) community. This study aims to recruit a large cohort of caregivers of adolescents and young adults with DS to develop and validate the Down Syndrome Regression Rating Scale, a novel low-burden assessment tool to aid in the screening and monitoring of DSRD.

PI_NAMEs: BROWN, RUTH C (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Activities of Daily Living;Acute;Address;Adolescent;Adolescent and Young Adult;Adult;Affect;Assessment tool;associated symptom;Benchmarking;brain behavior;Caregivers;Catatonia;Clinic;Clinical;clinical care;Cognitive;cognitive function;cognitive interview;cohort;Cohort Studies;Communities;community engaged approach;Complex;Consensus;Consumption;cost;Country;Data Collection;Delphi Study;Detection;Development;Diagnosis;diagnostic accuracy;diagnostic criteria;Diagnostic tests;disability;Disease;disorder risk;Down's Syndrome;Emotional;Enrollment;Ensure;Etiology;Evaluation;executive function;Exhibits;experience;externalizing behavior;Factor Analysis;Family;Feedback;Financial Hardship;Focus Groups;Funding;Genes;high risk;improved;indexing;Individual;insurance claims;interest;Intervention;Measurement;Measures;Medical;Mental Depression;Modeling;Monitor;Moods;motor symptom;National Institute of Child Health and Human Development;National Institute of Mental Health;Needs Assessment;neuropsychiatry;novel;Outcome Measure;Parents;Patients;Persons;Pharmaceutical Preparations;Phenotype;Physicians;Prevalence;Prevention strategy;Process;Provider;Psychopathology;Public Health;Recommendation;Recording of previous events;recruit;Reporting;Research;Research Personnel;resilience;Risk;Sampling;screening;Sensitivity and Specificity;Services;skills;Specialist;Specificity;Stress;Structure;Symptoms;Syndrome;Testing;Time;tool;Travel;Treatment outcome;treatment response;Validation

PROJECT_TITLE: Development and Validation of the Down Syndrome Regression Rating Scales

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: SALOMON, MATTHEW PHILIP (contact)

PROJECT_TERMS: Achievement;Address;Advanced Malignant Neoplasm;African American;anti-cancer research;Bioinformatics;Biological;Biometry;Black American;California;cancer health disparity;Cancer health equity;Cancer Research Project;Caring;Clinical;Communities;Community Outreach;Comprehensive Cancer Center;computerized data processing;computing resources;Data;Data Analyses;data cleaning;Data Collection;data management;Data Management Resources;data repository;Data Science;Data Set;data sharing;Data Storage and Retrieval;Databases;design;Development;Doctor of Philosophy;drug development;E-learning;Education;education research;Educational Materials;Educational workshop;Ensure;Environmental Exposure;Evaluation;Event;exome sequencing;experimental study;federated data;Florida;Funding;Future;Gene Expression Profiling;genomic data;Goals;Grant;Health;Health Disparities Research;health equity;high dimensionality;High-Throughput Nucleotide Sequencing;Hispanic;human data;Individual;innovation;Institution;Laboratories;lectures;Malignant Neoplasms;Manuscripts;meetings;member;Methodology;Methods;mortality;Mutation;Mutation Analysis;novel;Occupations;outreach;Pilot Projects;Population;Preparation;Procedures;public database;Publications;Quality Control;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Resources;Schedule;Science;Series;Services;single cell sequencing;software as a service;software development;Source;System;Techniques;Tissue Model;Training;Training Support;transcriptome sequencing;Triage;Underserved Population;Universities;University of Southern California Norris Cancer Center;web site;Work

PROJECT_TITLE: Bioinformatics, Statistical and Methodological Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Machine Learning and Artificial Intelligence;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Stimulant Use and Misuse;Substance Misuse;Substance Misuse Prevention

PHR: NARRATIVE Drug checking services, which voluntarily provide individuals who use drugs with information about the contents of specimens of unknown composition, show promise as an overdose prevention tool. However, the scale-up of effective drug checking services is hampered by current technologies, which are costly, technically complex, non- portable, or non-adaptive to emerging drug threats. Novel technologies must address these barriers, and we therefore propose developing and validating DoseCheck, a non- targeted point-of-care technology with the capacity to provide rapid and adaptable identification of emerging threats in order to reduce access barriers to drug checking services in the context of the ongoing North American overdose epidemic.

PI_NAMEs: HALL, DREW ALEXANDER;WERB, DANIEL M (contact)

PROGRAM_OFFICER_NAME: FOSTER, KATRINA L

PROJECT_TERMS: Address;American;Anesthetics;Applied Research;assay development;authority;Automobile Driving;Benzodiazepines;Biological Assay;Biosensor;Canada;carfentanil;Cities;Client;Cocaine;Complex;cost;Country;COVID-19;detection method;Development;Disease Outbreaks;Drug Controls;drug market;Drug usage;Drug user;ecstasy;Effectiveness;Epidemic;Exercise;experience;Federal Government;Fentanyl;Forensic Medicine;Grant;Health;Heroin;high risk;Human;Improve Access;Individual;instrument;interest;Intervention;Investigation;Ketamine;Legal;Machine Learning;machine learning algorithm;Marketing;Mass Spectrum Analysis;Medical Examiners;meetings;Methamphetamine;Morphine;mortality;multidisciplinary;Nature;new technology;Norfentanyl;North America;novel;Opioid;Overdose;overdose prevention;Overdose reduction;Overdose reversal;overdose risk;overdose risk behaviors;Performance;Persons;Pharmaceutical Preparations;Plasma;point of care;Point of Care Technology;Point-of-Care Systems;Policies;Population;Populations at Risk;prevent;preventive intervention;Psychotropic Drugs;public health emergency;Quality-Adjusted Life Years;reagent testing;repository;Research Infrastructure;Risk;Sampling;scale up;service providers;Services;Specimen;Spectroscopy, Fourier Transform Infrared;Stimulant;substance use;synthetic opioid;System;Technical Expertise;Technology;technology development;test strip;Testing;Time;tool;United States;Urine;Validation;Work

PROJECT_TITLE: Development and validation of a novel point-of-care technology for rapid non-targeted identification of emerging opioid and other drug threats


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Orphan Drug;Pancreatic Cancer;Prostate Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Urologic Diseases

PI_NAMEs: SALHIA, BODOUR  (contact)

PROJECT_TERMS: Address;African American;anti-cancer research;Archives;Basic Science;biobank;Biocompatible Materials;Bioinformatics;Black race;California;cancer health disparity;cancer type;career development;Caring;Cell Line;Chemistry;clinical database;clinical translation;Collaborations;Collection;Complex;Conscious;crosslink;Data;Databases;Development;Development Plans;Disparity;drug development;Education;Ensure;ethnic diversity;Evaluation;experience;FDA approved;First Independent Research Support and Transition Awards;Florida;Funding;Future;genomic data;Genomics;Goals;health equity;Hispanic;Human;Implant;Individual;Institution;Latinx;Latinx population;Lead;Leadership;Link;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Research;member;Mentorship;Methodology;Mission;Modeling;Molecular;neoplasm registry;Normal tissue morphology;novel;Organoids;Outcome;pancreatic cancer patients;Pathologic;patient derived xenograft model;patient population;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pilot Projects;Plasma;Population;Prostate;Race;racial diversity;recruit;repository;Research;research and development;Research Personnel;Research Project Grants;Residual state;Resource Sharing;Resources;response;RNA;Role;Sampling;Scientist;Serum;skills;Specimen;success;Technology;technology development;Testing;Tissue Banks;Tissue Model;Tissue Sample;Tissues;Translational Research;tumor;Tumor Tissue;Universities;virtual

PROJECT_TITLE: Tissue Modeling Core


ORG_CITY: CHEYENNE

ORG_NAME: WYOMING STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: WY

PHR: PROJECT NARRATIVE The project “Continued Enhancement of the WDA Manufactured Food Regulatory Program Standards to Ensure Sustainability” is designed to ensure that the Wyoming Department of Agriculture, Consumer Health Services (WDA/CHS) Manufactured Food Program continues to improve and be sustainable by using applicable practices and policies. Wyoming Department of Agriculture, Consumer Health Services intends to provide training to personnel; enhance program development to ensure food safety requirements are being met throughout the state; improve software to better equip inspection personnel; and provide outreach to industry to gain stakeholder input and advance the Manufactured Food Program. The ultimate desirable outcomes for this project would be for WDA/CHS to remain in full implementation and full conformance of all ten of the Manufactured Food Regulatory Program Standards (MFRPS) and continually improve the state’s Manufactured Food Program.

PI_NAMEs: LATHAM, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: D'ANGELO, JENNIFER


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pancreatic Cancer;Racial and Ethnic Minority Health Research;Rare Diseases

PI_NAMEs: HAN, BO  (contact)

PROJECT_TERMS: 3-Dimensional;Acinar Cell;Acinus organ component;Address;African American;African American population;anti-cancer research;biophysical properties;biophysical techniques;Black Populations;Black race;California;Cancer cell line;cancer health disparity;Caring;Cell Line;Cell Reprogramming;Cells;Chronic;chronic pancreatitis;Coculture Techniques;Collagen;combat;comorbidity;Conditioned Culture Media;Data;Development;Disease;Disparity;Duct (organ) structure;Ductal Epithelial Cell;Early Diagnosis;Early treatment;Education;effective therapy;Event;Experimental Models;Extracellular Matrix;Fibronectins;Florida;Funding;Gender;Gene Expression;Genes;Genetic Markers;Goals;health equity;Heterogeneity;Hispanic;Hispanic Populations;Histone Deacetylase Inhibitor;Human;Immune;Immunofluorescence Immunologic;improved;In Situ;Incidence;Individual;Inflammation;Inflammatory;inhibitor;Institution;irritation;Latino;Latino Population;Lesion;Link;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic stress;Metaplasia;Methods;Microscopic;Molecular;mortality;mouse model;Normal Range;novel;Outcome;Oxidative Stress;Pancreas;pancreas development;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic metaplasia;pancreatic stellate cell;Pathway interactions;Patients;Penetration;Peptide Hydrolases;Pharmaceutical Preparations;pharmacologic;Phenotype;Pilot Projects;prevent;Process;Prognosis;Publishing;Race;racial disparity;Role;Sampling;single cell ATAC-seq;Stains;stellate cell;Stromal Cells;System;therapeutic target;Tissues;transcriptome sequencing;treatment response;Trichostatin A;tumor microenvironment

PROJECT_TITLE: Full Project 3


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse;Women's Health Research

PHR: Social safety net programs are critical upstream factors that offset economic stress and can affect people’s ability to access basic shelter, health care and food-related needs, which are particularly salient among parenting women who use drugs. The effects of these programs (Unemployment Insurance [UI], Supplemental Nutritional Assistance Programs [SNAP], Temporary Assistance for Needy Families [TANF], the Earned Income Tax Credit [EITC], and Medicaid) on opioid outcomes remains underexplored; the joint impact of these programs on opioid- related outcomes has not been studied. We propose a mixed-methods convergent parallel design to comprehensively evaluate the separate and combined effects of UI, SNAP, TANF, EITC, and Medicaid (including pathways and mediators), on opioid-related outcomes among low-income parenting women; findings will have concrete real-world impact providing actionable and politically feasible recommendations for changes in these programs to reduce opioid-related burden and promote women’s wellbeing.

PI_NAMEs: MARTINS, SILVIA SABOIA (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: Address;Adult women;Affect;Age;Aid to Families with Dependent Children;Alcohol consumption;behavioral outcome;beneficiary;Black race;black women;Caregivers;caregiving;Cessation of life;Child;Child Rearing;childcare allowance;Chronic;Cities;cohort;Communities;coronavirus pandemic;Death Rate;design;dietary supplements;Drug usage;Economics;Eligibility Determination;Emergency department visit;Employment Status;Epidemic;Ethnic Origin;Ethnography;experience;federal poverty level;food insecurity;Harm Reduction;Health;health care availability;health data;Health Food;Healthcare;Healthcare Systems;Hospitalization;Income Tax;Indigenous;Individual;Intervention;Interview;Joints;Low income;Mediating;Mediation;Mediator;Medicaid;Medical;medication for opioid use disorder;men;Methods;National Institute of Drug Abuse;Not Hispanic or Latino;Opioid;opioid misuse;opioid mortality;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;Pathway interactions;Pattern;Personal Satisfaction;Persons;Policies;Politics;Poverty;programs;public health emergency;Race;Recommendation;Reporting;reproductive;Research;Resources;Risk;Role;safety net;Services;Severities;Shelter facility;social;social service provider;social stigma;Stress;Structure;substance use treatment;Surveys;Testing;unemployment insurance;United States;Update;Variant;Woman

PROJECT_TITLE: Social safety net programs as  interventions to reduce opioid-related harms in reproductive-age women


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Orphan Drug;Racial and Ethnic Minority Health Research;Rare Diseases;Tobacco;Tobacco Smoke and Health

PI_NAMEs: OFFRINGA, ITE A (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;African American;African American population;alpelisib;Alveolar;alveolar epithelium;Amides;Angiogenesis Inhibition;anti-cancer research;anti-cancer therapeutic;BAY 54-9085;Bioinformatics;Biological;Biological Factors;Biological Models;Biomedical Engineering;Black American;black men;Black Populations;Black race;black women;bone;BRAF gene;Bronchiolo-Alveolar Adenocarcinoma;California;cancer cell;cancer health disparity;Carcinogens;Caring;Cell Line;Cell Survival;Cells;Collection;Combined Modality Therapy;cytotoxicity;Data Analyses;Development;Disparity;DNA;Doctor of Philosophy;driver mutation;Drug Combinations;drug development;Education;effective therapy;Epidermal Growth Factor Receptor;Epithelial Cells;Erlotinib;Ethnic Origin;Ethnic Population;exome sequencing;exposure to cigarette smoke;Florida;follow-up;Formalin;Funding;Gel;Gelatin;Gene Mutation;Genes;Genetic;Growth;health disparity;health equity;high risk;In Vitro;in vitro Model;Individual;Inhalation;inhibitor;innovation;interdisciplinary collaboration;Invaded;Knowledge;KRAS2 gene;Leukocytes;Lung Adenocarcinoma;Malignant Bone Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;MAP Kinase Gene;Measures;Medicine;member;men;Metabolism;Metastatic Neoplasm to the Bone;Methodology;Methods;migration;Modeling;Molecular;mutant;Mutate;Mutation;Neoplasm Metastasis;neoplasm registry;Nicotine;novel;novel therapeutics;Organoids;osteogenic;Paraffin Embedding;Pathway interactions;Patients;Pattern;Perfusion;Pharmaceutical Preparations;PIK3CG gene;Porosity;Printing;progenitor;Race;racial difference;racial population;Resources;response;Risk Factors;Sampling;Site;Source;STK11 gene;System;targeted treatment;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Time;Tissue Model;Tobacco smoke;tool;TP53 gene;Treatment Efficacy;treatment response;two-dimensional;Variant;Vascular Endothelial Cell;Woman;Work

PROJECT_TITLE: Full Project 4


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

PHR: PROJECT NARRATIVE A portion of Lyme disease patients continue to experience persistent symptoms even after antibiotic treatment, resulting in a condition called post-treatment Lyme disease syndrome. The cause of this syndrome is unknown but has been proposed to be caused by continuous presence of Borrelia burgdorferi, the causative Lyme disease agent. The experiments in this proposal will examine the roles of the immune response and genetics play in the development of this persistent disease and use novel state of the art tests for detection of Borrelia burgdorferi in patients with post-treatment Lyme disease syndrome.

PI_NAMEs: TOKARZ, RAFAL  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Address;Animal Model;Animals;Antibiotic Therapy;Antibody Response;Antigens;B-Lymphocytes;Biological Assay;Biology;Borrelia burgdorferi;Carditis;Catalogs;Cerebrospinal Fluid;chronic infection;co-infection;Cognition Disorders;cohort;Coupled;Data;density;Detection;detection test;Development;Disease;DNA;Epitope Mapping;Epitopes;experience;experimental study;Exposure to;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic architecture;Genetic Polymorphism;Genetic Transcription;Genome;Genomics;Genotype;Human;Immune response;Immunoglobulin G;Immunoglobulin M;immunoreactivity;improved;Inbred BALB C Mice;Infection;insight;Investigation;Link;Lyme Arthritis;Lyme Disease;Molecular;Molecular Analysis;Mus;next generation;next generation sequencing;novel;Order Spirochaetales;OspC protein;pathogen;Pathogenicity;patient response;Patients;Peptides;Peromyscus;persistent symptom;Plasmids;Play;Post Treatment Lyme Disease Syndrome;Predisposing Factor;prevent;response;RNA;Role;Serology;Serotyping;Serum;Severity of illness;specific biomarkers;Specimen;Syndrome;Testing;tick-borne;Tick-Borne Diseases;Tissue Sample;Tissues;tool;transcriptome;Variant;Vertebrates;Work

PROJECT_TITLE: Genetic basis for persistence of Borrelia burgdorferi


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nanotechnology;Orphan Drug;Pancreatic Cancer;Racial and Ethnic Minority Health Research;Rare Diseases

PROJECT_TERMS: Address;African American population;anti-cancer research;anticancer activity;Black Bear;Black race;California;Cancer Etiology;Caring;Cells;Cessation of life;chemotherapy;cohort;Cytidine Deaminase;Data Set;DCK gene;Deoxycytidine Kinase;design;Diagnosis;Drug Kinetics;Drug usage;Education;efficacy evaluation;efficacy testing;enzyme activity;Epidermal Growth Factor Receptor;Epigenetic Process;ethnic diversity;experience;experimental study;Exposure to;Fc Receptor;Florida;Fluorouracil;Formulation;gemcitabine;Gene Expression;Genetic;Goals;health equity;High Prevalence;Human;improved;in vivo;Incidence;Investigation;irinotecan;Leucovorin;lipophilicity;Malignant Neoplasms;Measures;Metabolism;Modeling;mortality;mouse model;multi-ethnic;Mus;nanoparticle;Nucleoside Transporter;Operative Surgical Procedures;Organoids;oxaliplatin;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic neoplasm;pancreatic PDX models;patient derived xenograft model;patient stratification;Patients;personalized chemotherapy;Phosphorylation;Pilot Projects;Population Heterogeneity;protein expression;Proteins;Publishing;racial difference;racial diversity;Resistance;response;Risk;RNA;Safety;Sampling;SNP genotyping;Solubility;subcutaneous;Surface;Survival Rate;Systemic Therapy;targeted delivery;Testing;therapy outcome;Toxic effect;treatment choice;Treatment Efficacy;tumor;tumor growth;tumor xenograft;uptake;Variant;Wild Type Mouse

PROJECT_TITLE: Pilot Project 5


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse;Substance Misuse Prevention

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE  Although medications for opioid use disorders can markedly reduce overdoses, most people in treatment discontinue treatment prematurely. Quality measures that inform opioid treatment programs of their retention rates relative to their peers, may motivate those programs to undertake quality improvement activities to improve retention, such as by helping patients navigate logistical barriers to receiving treatment. This study will test approaches to developing and disseminating retention and outcome measures to opioid treatment programs.

PI_NAMEs: MARK, TAMI L (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Address;arm;Benchmarking;Buprenorphine;California;Caring;Characteristics;Clinic;Clinical;Cluster randomized trial;Connecticut;County;Disparity;Emergency department visit;experience;Federal Government;Feedback;flexibility;Fostering;Health;Health Personnel;Health Services;Health system;Helping to End Addiction Long-term;Hospitalization;improved;improved outcome;Individual;International;Knowledge;Literature;Los Angeles;Measurement;Measures;medication for opioid use disorder;Methadone;Monitor;mortality;National Institute of Drug Abuse;opioid mortality;opioid treatment program;opioid use disorder;Outcome;Outcome Measure;Overdose;overdose prevention;Overdose reduction;overdose risk;patient navigation;patient oriented;Patients;peer;Performance;Persons;Pharmaceutical Preparations;Policies;Population;premature;Prevention strategy;Probability;programs;Provider;Psychometrics;randomized, clinical trials;Recommendation;Research;Research Personnel;Research Project Grants;retention rate;Review Literature;Risk Reduction;social stigma;socioeconomic disadvantage;substance abuse prevention;Substance Use Disorder;System;telehealth;Testing;Time;Training;Transportation;treatment as usual;treatment program;United States;United States Dept. of Health and Human Services;Universities;Variant;web site

PROJECT_TITLE: HEAL Initiative: Research to Foster an Opioid Use Disorder Treatment System Patients Can Count On


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: RICHEY, JOYCE M (contact)

PROJECT_TERMS: Accountability;Achievement;Advocate;African American;Annual Reports;anti-cancer research;Award;Benchmarking;Black race;California;cancer health disparity;career development;Career Mobility;Caring;Collaborations;Communities;Community Health Education;Community Outreach;Data;Decision Making;design;Development;Doctor of Pharmacy;Doctor of Philosophy;Documentation;Education;Education and Outreach;education research;Educational workshop;Effectiveness;Ensure;Evaluation;Exhibits;Extramural Activities;Faculty;Florida;Fostering;Funding;Goals;Grant;Health Disparities Research;health equity;Hispanic;implementation evaluation;improved;Individual;inter-institutional;Investments;Latino;Leadership;Measures;meetings;member;Mentors;minority trainee;Monitor;multidisciplinary;Online Systems;Outcome;Outcome Assessment;Pathway Analysis;Peer Review;Population;Process;Program Evaluation;programs;Publications;Quantitative Evaluations;Recommendation;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resource Allocation;Resource Sharing;Resources;Scholarship;Science;Scientist;Social Network;success;Surveys;symposium;Training;Underrepresented Minority;Universities;webinar

PROJECT_TITLE: Planning and Evaluation Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE A hallmark symptom of opioid use disorder is compulsive drug use, defined as drug intake despite negative consequences. We will elucidate how opioid self-administration induces transcriptional adaptations within the ventral pallidum with single-cell resolution, and how adaptations within functional ensembles of ventral pallidal neurons predict the development of compulsive opioid intake in a subset of individuals. This insight will be critical for understanding individual variability in susceptibility to prescription opioid abuse and for preventing or reversing the transition to compulsive drug intake in opioid use disorder.

PI_NAMEs: CREED, MEAGHAN C (contact);SAMINENI, VIJAY K

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Address;adverse outcome;Affect;American;Anatomy;Area;Atlases;Basal Ganglia;Behavior;Behavioral;Binding;Brain;Candidate Disease Gene;candidate identification;Catalogs;Cell Differentiation process;Cell Nucleus;cell type;Cells;Censuses;Centers for Disease Control and Prevention (U.S.);Classification;Communities;Conflict (Psychology);Data Set;Development;Disease;Drug Exposure;Drug resistance;drug seeking behavior;Drug usage;Epigenetic Process;epigenomics;Equilibrium;Event;Exhibits;experience;experimental study;Exposure to;Extinction;foot;Foundations;Future;Gene Expression Profile;Genetic;Genetic Transcription;Genomics;Globus Pallidus;Glutamates;Goals;Habenula;Health;Immediate-Early Genes;Individual;Individual Differences;individual variation;insight;Intake;Investigation;Lateral;Measures;Modeling;Molecular;motivated behavior;Motivation;mRNA Expression;Mus;neural;neural circuit;neurochemistry;neuromechanism;Neurons;novel;Nucleus Accumbens;Opioid;opioid exposure;opioid therapy;opioid use;opioid use disorder;Outcome;overdose death;Oxycodone;oxycodone self-administration;Patients;Peptide Initiation Factors;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;Population;Predisposition;prescription opioid;prescription opioid abuse;prescription opioid misuse;prevent;programs;Public Health;Punishment;recruit;Relapse;Reporting;Resistance;Resolution;Resources;Rewards;Risk;Rodent;Role;Self Administration;Series;Shock;single cell sequencing;single nucleus RNA-sequencing;Specificity;Structure;Surveys;Symptoms;targeted treatment;Taxonomy;Technology;Testing;Therapeutic;Time;transcription factor;transcriptome;transcriptomics;Translating;Ventral Tegmental Area;Viral Vector;Virus;Work

PROJECT_TITLE: Ventral pallidal transcriptional adaptations underlying punishment-resistant opioid intake


NIH_SPENDING_CATS: Clinical Research;Genetic Testing;Genetics;Human Genome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Growth restricted preterm infants experience high rates of morbidity and mortality. The prevalence of genetic disorders and contribution to morbidity and mortality are unknown in this population. The purpose of this project is to determine the contribution of genetic disorders to preterm growth restricted birth and to subsequent morbidity and mortality.

PI_NAMEs: HAYS, THOMAS  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: 37 weeks gestation;Aneuploidy;Area;attributable risk;Birth;burden of illness;career development;Categories;Clinical;Clinical Data;clinical data warehouse;Clinical Management;clinical practice;clinically significant;cohort;congenital anomalies of the kidney;Copy Number Polymorphism;Data Set;Databases;defined contribution;Development;Development Plans;Diagnosis;diagnostic strategy;diagnostic value;Disease;Environmental Risk Factor;Epidemiologic Factors;Epidemiologist;Epidemiology;epidemiology study;Etiology;exome sequencing;experience;Family;Funding;Genes;Genetic;genetic counselor;Genetic Diseases;Genetic Research;genetic testing;genetic variant;genomic data;Genomic medicine;Genomics;Gestational Age;Goals;Growth;health record;high risk;high risk population;Home;Human Genetics;improved;Infant;Infection;Institution;Investigation;K-Series Research Career Programs;Life;Link;loss of function;Medical;Medical center;Medical Genetics;Mendelian disorder;Mentors;Molecular;Morbidity - disease rate;mortality;mortality risk;neonatal health;Neonatal Intensive Care Units;Neonatology;Neurocognitive Deficit;Newborn Infant;novel;Oligonucleotides;Other Genetics;Outcome;Pathogenesis;Pathogenicity;perinatal medicine;Population;Positioning Attribute;Pregnancy;Premature Birth;Premature Infant;prenatal exposure;Prevalence;prospective;Publishing;rare genetic disorder;Records;recruit;Research;Research Personnel;Resources;Retrospective cohort;Risk;Risk Factors;sex;skills;Small for Gestational Age Infant;social factors;statistics;Students;Testing;Training;Universities;Variant;Weight;Work

PROJECT_TITLE: The Genetic Basis of Morbidity and Mortality in Small for Gestational Age Preterm Infants

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


PROJECT_TERMS: Academy;Achievement;Address;Admission activity;Advanced Malignant Neoplasm;African American;anti-cancer research;Applications Grants;Applied Research;Award;Basic Science;Behavioral;Behavioral Research;Benchmarking;Bioinformatics;Biomedical Research;Biometry;Black Populations;Black race;California;cancer health disparity;Cancer health equity;career;Career Choice;career development;Caring;Clinical;Clinical Research;Collaborations;Communities;Comprehensive Cancer Center;cost;Data;Discipline;Discipline of Nursing;Doctor of Philosophy;Education;education research;Educational Activities;Engineering;Ensure;Environment;ethnic diversity;Ethnic Origin;Evaluation;experience;Fellowship;Florida;Funding;Genomics;Goals;Government;graduate student;Grant;Health;health care disparity;Health Disparities Research;health equity;Health Professional;Healthcare Systems;higher education;Hispanic;Historically Black Colleges and Universities;Immersion;Impact evaluation;improved;Individual;Institution;interest;International;K-Series Research Career Programs;Knowledge;Latino;Latino Population;Malignant Neoplasms;Manuscripts;medical schools;Medicine;meetings;Mentors;Mentorship;Minority Graduate Student;Minority Groups;minority trainee;Modeling;Monitor;multidisciplinary;Native American Tribe;Oncology;Outcome;Outcomes Research;Patients;peer;Pharmacy facility;Population;Population Research;Postbaccalaureate;Postdoctoral Fellow;posters;pre-clinical;pre-doctoral;Process;Program Evaluation;programs;Public Health;Publishing;Publishing Peer Reviews;Race;racial diversity;recruit;Research;Research Personnel;Research Training;response;Science;Scientist;Site;Structure;Students;success;Training;training opportunity;Training Programs;Training Support;Tribal group;undergraduate student;Underrepresented Minority;United States National Academy of Sciences;United States National Institutes of Health;Universities;University of Southern California Norris Cancer Center

PROJECT_TITLE: Research and Education Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE During the COVID-19 pandemic, the use of telehealth expanded in all healthcare services, including for reproductive health. This work proposes to learn the ways in which telehealth for reproductive healthcare affects timing, costs, and follow-up care, whether telehealth reaches people in areas with greater health inequities, and the attributes of telehealth that patients want. This project will address how telehealth services can be optimized for people of color, low- income people, and immigrants to increase digital inclusion and health equity.

PI_NAMEs: UPADHYAY, USHMA DESAI (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;access disparities;Address;Affect;Area;asynchronous communication;Biometry;Caring;Censuses;Clinic;Clinic Visits;Clinical;cohort;Colorado;Communication;Consultations;Contraceptive methods;Contracts;cost;COVID-19 pandemic;design;Devices;digital;disparity reduction;Electronics;Eligibility Determination;Enrollment;Ensure;Equity;experience;experimental study;Face;follow-up;Funding;geographic disparity;Geography;Goals;Health;health care availability;health care disparity;health care service;health equity;health inequalities;health organization;Health Personnel;Health Services;Healthcare;Immigrant;indexing;Induced Abortion;Inequity;innovation;Institutional Racism;Insurance;Intake;interest;Internet;Language;Learning;Legal;Legal Status;literacy;Low Income Population;Mail Order;marginalization;marginalized population;Market Research;Methods;Mifepristone;Misoprostol;Outcome;Patients;people of color;Persons;Pharmaceutical Preparations;Pharmacy facility;Policies;policy recommendation;Population;preference;Pregnancy;Pregnancy Outcome;Primary Health Care;Privacy;Privatization;Progesterone;programs;Provider;recruit;Reproductive Health;Research;Role;Safety;Schools;Secure;service delivery;Services;Site;social;social vulnerability;Spanish/English;Stigmatization;structural determinants;Surveys;Technology;telehealth;Telephone;Text;Time;Translations;Uterus;Virginia;Visit;Women's Health;Work

PROJECT_TITLE: Telehealth and Reproductive Health Equity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE: Successful completion of this proposal will lead to a trustworthy zero-code federated learning (FL) software framework, lowering the barrier to leverage data from under-served populations in large-scale, secure, de- centralized multi-institutional collaborations, without the need to share patient data, thereby i) overcoming legal, privacy, and data-ownership concerns, and ii) paving the way to address health disparities and inequities, towards accelerating discovery in healthcare. This framework will further support the clinical impact and lifecycle of FL studies by offering a) pre-trained breast cancer risk assessment models leveraging multi-site, ethnically diverse data of women undergoing breast screening, and functionality specific to b) improving these pre-trained models, by including additional geographically diverse sites, c) data synthesis for data augmentation & privacy preservation, based on realistic synthetic data matching each site’s local patient population characteristics, and d) an automated mechanism for quantitative & interpretable determination of optimal privacy preservation.

PI_NAMEs: BAKAS, SPYRIDON  (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute Respiratory Distress Syndrome;Address;Appearance;artificial intelligence model;Astronauts;Attention;Awareness;Benchmarking;Brain Neoplasms;Breast Cancer Detection;Breast Cancer Risk Factor;breast density;cancer diagnosis;cancer type;Cause of Death;Classification;Clinical;clinical translation;Code;Collaborations;Collection;COVID-19 mortality;Data;Data Analyses;Data Set;data sharing;Decentralization;deep learning model;Development;Diagnosis;Diagnostic Procedure;digital;Digital Breast Tomosynthesis;Digital Mammography;digital measure;Disease;diverse data;Early Diagnosis;educational atmosphere;Eligibility Determination;Environment;ethnic diversity;Evaluation;federated learning;Feedback;Friends;frontier;Funding;generative adversarial network;Geography;Goals;health disparity;health disparity populations;health inequalities;Health Insurance Portability and Accountability Act;Health system;Healthcare;Histopathology;Image;imaging modality;improved;Infrastructure;infrastructure development;Institution;laboratory development;Learning;Legal;Libraries;Licensing;Life Cycle Stages;Lymphocyte;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammography;Measures;Medical Imaging;model generalizability;Modeling;New York;novel;open source tool;Ownership;patient population;Patients;Performance;personalized screening;Physiological;Population Characteristics;Population Heterogeneity;pre-trained model;predictive modeling;Privacy;privacy preservation;Privatization;Probability;Procedures;prototype;Publishing;racial diversity;Radiation exposure;Radiation-Induced Cancer;Rare Diseases;Recommendation;Research;Resources;Risk Assessment;Risk Factors;risk stratification;routine screening;Scanning;screening;Secure;Sensitivity and Specificity;Site;Software Framework;Source Code;standard of care;synthetic data;Tissues;Training;Training Activity;trustworthiness;tumor;Tumor-Infiltrating Lymphocytes;Underserved Population;United States National Aeronautics and Space Administration;Woman;women's diagnosis;Work;Workload;X-Ray Medical Imaging

PROJECT_TITLE: Privacy-Aware Federated Learning for Breast Cancer Risk Assessment


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

PI_NAMEs: BAEZCONDE-GARBANATI, LOURDES A. (contact)

PROJECT_TERMS: Academy;Adult;Advisory Committees;Advocacy;Advocate;African American;anti-cancer research;behavior change;Benchmarking;Black American;Black church;Black Populations;Black race;California;cancer health disparity;cancer risk;Cancer Survivor;Caring;catalyst;Church;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community advisory board;community engaged research;Community Outreach;community-centered;Comprehensive Cancer Center;Country;Data;design;Development;Diagnosis;Diffusion of Innovation;Education;education research;Educational Activities;Educational Materials;Evaluation;evidence base;experience;Feedback;Florida;Funding;General Population;Goals;handbook;Health;health belief;health equity;Health Professional;Hispanic;Human;improved outcome;Individual;innovation;Institution;Knowledge;Latino;low socioeconomic status;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;member;men;Mission;Modeling;Multimedia;outreach;Pancreas;Persons;Policy Maker;Population;Population Heterogeneity;programs;Prostate;Reporting;Research;Research Personnel;Research Project Grants;Resources;Risk;Scientist;Spanish/English;Technology;Theoretical model;theories;tool;Training;Training Programs;Universities;University of Southern California Norris Cancer Center;Voice;web site;webinar;Work;Writing

PROJECT_TITLE: Outreach Core