ORG_CITY: BOSTON

PHR: NARRATIVE This project aims to create a "digital twin" of cancer tumors, specifically focusing on a treatment called radiopharmaceutical therapy, which targets cancer cells with precision. Using advanced computer models, our goal is to understand better and predict how cancer treatments work in individual patients, leading to more effective and personalized care. This research holds the promise of significantly improving the outcomes for children with neuroblastoma by offering insights that could lead to treatments that are both more effective in battling the disease and less harmful to the patient's overall health.

PI_NAMEs: MICHOR, FRANZISKA ;MICHOR, FRANZISKA  (contact)

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: absorption;Address;Affect;anti-cancer research;Apoptosis;Architecture;Area;Behavior;biological systems;Blood Vessels;Calibration;cancer care;cancer cell;cancer therapy;Cell Death;Cell Density;Cell model;Cells;Characteristics;Child;Childhood;Clinical;clinical application;Clinical Data;Clinical Trials;clinically relevant;combinatorial;Complement;Complex;Computer Models;Data;Deposition;Development;differential expression;digital twin;Disease;dosage;Dose;dosimetry;Environment;Event;Evolution;Excision;External Beam Radiation Therapy;extracellular;flexibility;Foundations;Generations;Goals;Growth;Growth Factor;Health;Heterogeneity;high risk;Hybrids;Image;Immune;improved;improved outcome;Individual;individual patient;innovation;insight;interest;Intervention;Label;Ligands;Magnetic Resonance Imaging;Malignant Neoplasms;mathematical model;Mathematics;metaiodobenzylguanidine;Methods;migration;Modeling;Molecular;Movement;Nature;Necrosis;neoplastic cell;Neuroblastoma;novel;novel therapeutics;Nutrient;Oncology;Parameter Estimation;parent grant;parent project;patient response;Patient-Focused Outcomes;Patients;Pediatric Oncology;personalized care;Pharmaceutical Preparations;pharmacokinetic model;Phenotype;Positioning Attribute;predicting response;Prediction of Response to Therapy;predictive modeling;pressure;primary endpoint;prototype;Radiation;radiation effect;Radiation Oncology;Radiation therapy;Radiation Tolerance;Radioactive Elements;Radiobiology;radiomics;Radiopharmaceuticals;Random Allocation;Reading;receptor;Recording of previous events;Research;response;Shapes;simulation;single photon emission computed tomography;Specificity;System;Techniques;Testing;Therapeutic;Time;tool;Treatment Efficacy;Treatment outcome;treatment response;treatment strategy;tumor;tumor heterogeneity;Validation;Work

PROJECT_TITLE: A digital twin to track and predict the evolution of pediatric neuroblastoma tumors


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative: Not required for this Administrative Supplement

PI_NAMEs: MATHEE-SCOTT, JANINE R (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Administrative Supplement;autistic children;word learning

PROJECT_TITLE: Prediction and Word Learning in Young Children with Autism Spectrum Disorder


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Emergency Care;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse;Telehealth

ORG_CITY: BIRMINGHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Opioid overdose deaths have reached historically high records in the United States and are particularly concentrated among patients after emergency department (ED) discharge. Evidence-based treatment modules to reduce repeat opioid overdose and mortality are lacking in this patient population. We propose to test a bundled intervention, including telehealth, peer support specialist, buprenorphine, and linkage for definitive care, that is designed to increase treatment uptake in this patient population post-ED discharge, reduce repeat opioid overdoses, and end overdose deaths.

PI_NAMEs: LI, LI  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;addiction;Address;Adherence;Adopted;Alabama;Buprenorphine;Caring;Cessation of life;Client satisfaction;Clinic;Communities;community based treatment;Continuity of Patient Care;craving;Data;design;effective therapy;Effectiveness of Interventions;Eligibility Determination;Emergency Care;Emergency department visit;Enrollment;Evidence based treatment;Expectancy;experience;fentanyl test;Frequencies;Goals;group intervention;health care service utilization;Health Status;high risk;Hospitals;improved;improved outcome;Intervention;Measures;medication for opioid use disorder;Mental Health;Methods;Modeling;Monitor;Motivation;multi-site trial;Naloxone;Nose;novel;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid use disorder;Outcome;Overdose;overdose death;Participant;participant retention;Patient Care;patient population;Patient Recruitments;Patients;peer;peer support;Phase;Physicians;Play;Population;Populations at Risk;primary outcome;programs;Quality of life;Randomized;Randomized, Controlled Trials;Records;Role;satisfaction;Service provision;Signal Transduction;social stigma;Specialist;Substance Use Disorder;telehealth;test strip;Testing;treatment as usual;treatment program;United States;Universities;uptake;Visit

PROJECT_TITLE: A Bundled Intervention to End Opioid Overdoses by Increasing Treatment Uptake Post Emergency Department Discharge

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-E (O1)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PI_NAMEs: BUKREYEV, ALEXANDER  (contact);GARCIA-BLANCO, MARIANO A.

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TITLE: Core A: Administrative Core


PROJECT_TITLE: Core B: Biosafety Level 4 Core


PROJECT_TITLE: Core C: Proteogenomics Core


PROJECT_TITLE: Core D: Bioinformatics and Modeling Core


PROJECT_TITLE: Research Project 2: Role of Posttranscriptional Regulatory Networks in the Pathogenesis of Ebola Virus Disease


PROJECT_TITLE: Research Project 3: Role of Posttranslational Protein Modifications in the Pathogenesis of Ebola Virus Disease


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Immunotherapy;Machine Learning and Artificial Intelligence;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Contact PD/PI: Barcellos-Hoff, Mary H NARRATIVE The type and pattern of immune cell infiltrate in breast cancer is of growing clinical importance as they associate with response to therapy and are the specific target of immunotherapy. However, the factors that influence the genesis of the type of tumor immune microenvironment (TiME) have yet to be defined. Our proposed systematic, mechanistic, high content analysis and modeling of the cellular and molecular mechanisms by which breast cancers evade the immune system focuses on will elucidate key factors that govern the origins of the TiME. Project Narrative Page 7

PI_NAMEs: BARCELLOS-HOFF, MARY HELEN (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: adaptive immunity;Affect;Aftercare;Age;Aging;Anti-Inflammatory Agents;anti-tumor immune response;Aspirin;biobank;Bioinformatics;Biology;Blood;Bone Marrow;BRCA1 gene;Breast Cancer Patient;Breast Cancer Risk Factor;cancer immunotherapy;carcinogenesis;Cell model;Cells;Characteristics;Chimera organism;Chronic;Clinical;clinically significant;Communities;conditional knockout;cyclooxygenase 2;cytokine;Data;deep learning;deep learning model;Development;Distal;Dose;Event;Exhibits;experimental study;Germ-Line Mutation;Goals;high risk population;Histologic;Hodgkin Disease;Immune;immune cell infiltrate;Immune system;immunoregulation;Immunotherapy;Infiltration;Inflammation;innovation;Lymphocyte;Lymphocytic Infiltrate;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary gland;Mammary Tumorigenesis;Methods;Modeling;molecular modeling;monocyte;Mus;Myeloid Cells;Natural Immunity;Nature;neoplasm resource;Non-Malignant;novel;Obesity;Outcome;Parabiosis;Pattern;Phenotype;Plasma;Population;pregnancy-associated breast cancer;Publishing;Radiation;Radiation therapy;Recording of previous events;Reporter;response;Role;Second Primary Cancers;Signal Transduction;Spleen;Stress;Syndrome;systemic inflammatory response;T cell infiltration;Testing;Tissues;Transforming Growth Factor beta;Transplantation;treatment response;tumor;Tumor Escape;Tumor Immunity;Tumor Subtype;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Virus Diseases;Woman;women's treatment

PROJECT_TITLE: Investigating the Genesis of Tumor Immune Microenvironment (TIME) as a function of Inflammation


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Hematology;Immunotherapy;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Sepsis

ORG_CITY: SEATTLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Contact PD/PI: Brakenridge, Scott Charles NARRATIVE Rather than acute mortality, a significant proportion of severe trauma and sepsis patients develop chronic critical illness (CCI), primarily characterized by recurrent infections, a failure to physically rehabilitate and dismal long- term outcomes. The overarching goal of our laboratory’s research program is to define distinct immunologic endotypes after severe injury or sepsis, to determine their role in the chronic inflammation, immunosuppression and muscle wasting, and to delineate their interactions, such that therapeutic interventions may be identified. Project Narrative Page 7

PI_NAMEs: BRAKENRIDGE, SCOTT CHARLES (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute;Administrative Supplement;Age;Area;Catabolism;Chronic;Clinical;clinical development;clinical phenotype;clinically relevant;Critical Illness;cytokine release syndrome;design;Ethnic Origin;Event;Failure;Functional disorder;Genomics;Goals;Health care facility;Heterogeneity;Homeostasis;Hospitals;Immune;Immune response;Immunity;Immunologics;Immunosuppression;indexing;Infection;Inflammation;Inflammatory;Innate Immune Response;innovation;Intensive Care Units;Laboratory Research;Mediating;Mediator;microbial products;mortality;Multiple Organ Failure;Muscle;Muscular Atrophy;novel;Organ;organ injury;Outcome;Pathway interactions;Patients;Phenotype;Production;programs;Race;Recurrence;recurrent infection;Refractory;Research;Resources;Resuscitation;Role;secondary infection;Sepsis;septic patients;severe injury;sex;Source;Supportive care;Survivors;Syndrome;systemic inflammatory response;Therapeutic Intervention;therapeutically effective;Time;Trauma;Trauma patient;Traumatic injury;Work

PROJECT_TITLE: Immunological Endotyping of Chronic Critical Illness after Severe Trauma or Sepsis: Administrative Supplement


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PI_NAMEs: WILKINS, CONSUELO HOPKINS (contact)

PROGRAM_OFFICER_NAME: ALTON, ANGELICA SUZETTE

PROJECT_TERMS: aged;All of Us Research Program;Area;Child;Childhood;Communities;Data;data access;design;Enrollment;Evaluation;evidence based guidelines;Exclusion;Feedback;Future;Genomics;Infrastructure;interest;marginalized population;member;Mental Health;Minority;Minority Groups;Parents;Participant;patient engagement;Personal Satisfaction;Phase;precision medicine;programs;recruit;Research;Research Personnel;Resources;Role;Science;Seminal;Surveys;Time;tool;Voice;Work;young adult

PROJECT_TITLE: Engaging Diverse Stakeholders in Genomic/Precision Medicine Research: The All of Us Research Program Engagement Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Rural Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PULLMAN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: Previous contingency management studies with AI/AN communities did not focus on stimulant use disorder. Contingency management is the only effective treatment for stimulant use. This study could elucidate the rapid translation and impact treatment outcomes of AI/AN communities.

PI_NAMEs: HIRCHAK, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Abstinence;addiction;Address;Adoption;Adult;Affect;Alaska Native;Alaska Native population;alcohol abstinence;Alcohol consumption;alcohol reward;alcohol use disorder;American Indian community;American Indian Population;American Indians;care coordination;Chippewa;Clinic;Clinical Trials;Communities;community advisory board;community based participatory research;Competence;contingency management;Control Groups;culturally appropriate intervention;drug abstinence;Drug usage;Education;effective intervention;effective therapy;Effectiveness;effectiveness evaluation;effectiveness-implementation RCT;effectiveness/implementation hybrid;ethnic diversity;Evidence based intervention;Exclusion;experience;Fatality rate;FDA approved;Feasibility Studies;Fentanyl;healing;health determinants;Hybrids;implementation barriers;implementation facilitators;implementation framework;implementation intervention;implementation outcomes;implementation research;implementation strategy;implementation tool;improved;Indigenous;indigenous community;Individual;Intervention;Interview;Link;marijuana use;medical specialties;Mental Health;Methamphetamine;mortality;novel;opioid misuse;opioid treatment program;Participant;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Poisoning;Policies;programs;Provider;Public Health;racial discrimination;racial diversity;Randomized, Controlled Trials;reinforcer;Research;research to practice;Resources;rurality;Sampling;secondary outcome;Services;Severities;Shoshone Indians;Site;Stimulant;stimulant use;stimulant use disorder;Structure;tool;Training;Translational Research;Translations;Treatment outcome;trial comparing;tribal community;Tribes;uptake;Urine;White Earth;Work

PROJECT_TITLE: Strength in HEALing: Indigenous Community-Led Strategies to Treat Stimulant Use


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Occupational accidents and work-related diseases still occur on a tremendous scale with over 90% of worker injuries and deaths occurring in low- and middle-income countries (LMICs). Many occupational safety and health interventions have been developed and implemented in high-income countries which significantly improve employees’ safety and health; however, their established methods often use in-person training that is impractical in LMICs due to limited resources and budgetary restrictions. Using an mHealth (mobile-based technology for improving health) approach as a foundation, an evidence- based Safety Climate intervention program (which incorporates effective instructional methods and training strategies developed by our team and delivered via mobile methods) will be created and tested in Malaysian companies to address the significant knowledge gap regarding the impact of Safety Climate interventions on workers’ health and safety in LMICs.

PI_NAMEs: HUANG, YUENG-HSIANG  (contact)

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Accidents;Address;Back;Behavior;Behavioral;Benchmarking;Cellular Phone;Cessation of life;Climate;climate science;cognitive interview;Collaborations;Counseling;Country;Data;Data Collection;design;Development;Disease;effectiveness evaluation;Empirical Research;Employee;evidence base;experience;Feedback;Foundations;Frontline worker;Goals;handheld mobile device;Health;Healthcare;high risk;Hospitals;improved;Income;Industry;Injury;Instruction;Intervention;intervention program;Knowledge;Learning;Literature;low and middle-income countries;Malaysia;Malaysian;manufacture;Measures;Medicine;Methods;Occupational Accidents;occupational health/safety;Occupational injury;Occupational Safety;Outcome;Participant;Perception;Persons;Phase;pilot test;programs;Public Health;Reaction;Research;Research Design;Research Personnel;Resources;Safety;safety outcomes;Surveys;Tablets;Techniques;Technology;Testing;tool;Training;Translating;Translations;Validation;Validity and Reliability;Work;worker safety;Workplace

PROJECT_TITLE: Enhancing Malaysian Workers' Safety and Health through Safety Culture and Climate mHealth Interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-P (56)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Orphan Drug;Pediatric;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CORAL GABLES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Narrative Over 300 different inherited mutations have been found in IKs channels that decrease the activity of IKs channels and cause a prolonged cardiac action potential (i.e. Long QT Syndrome), which can lead to cardiac arrhythmias in patients. We have identified a family of compounds that activate IKs channels, shorten the cardiac action potential, and are antiarrhythmic when applied to cardiomyocytes. We will here test variants of these compounds in order to develop a drug that will shorten the cardiac action potential to prevent cardiac arrhythmias and sudden cardiac deaths in Long QT Syndrome patients.

PI_NAMEs: BARRO-SORIA, RENE  (contact);DYKXHOORN, DEREK MICHAEL;LARSSON, HANS PETER;ODENING, KATJA ;TIELEMAN, PETER

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Action Potentials;Animal Model;Animals;Anti-Arrhythmia Agents;Aromatic Amino Acids;Arrhythmia;Binding;Binding Sites;Calcium Channel;Cardiac;Cardiac Myocytes;Cells;Cessation of life;Child;Clinical;Clinical Trials;Computer Simulation;Computers;Data;data modeling;Defect;Dependence;Development;efficacy testing;Electrocardiogram;Electrodes;Exhibits;experimental study;Family;functional restoration;Future;Heart;Human;human induced pluripotent stem cells;In Vitro;in vivo;Individual;induced pluripotent stem cell derived cardiomyocytes;Inherited;insight;Length;Long QT Syndrome;Membrane Potentials;Molecular;Molecular Mechanisms of Action;Movement;Mutation;novel;novel therapeutics;Oryctolagus cuniculus;Patients;personalized medicine;Pharmaceutical Preparations;Pharmacologic Substance;Polyunsaturated Fatty Acids;Potassium;Potassium Channel;preclinical study;prevent;Prevention;Property;Research Personnel;Risk Factors;sensor;simulation;Site-Directed Mutagenesis;Sodium Channel;Structure;sudden cardiac death;System;Techniques;Testing;Transgenic Animals;Transgenic Model;Transgenic Organisms;Variant;Ventricular;Ventricular Fibrillation;voltage;voltage clamp;young adult

PROJECT_TITLE: Polyunsaturated fatty acids as anti-arrhythmic agents.

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Burden of Illness;Cancer;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: WARD, KEVIN  (contact)

PROJECT_TERMS: Annual Reports;anti-cancer research;Cancer Control;Cancer Patient;cancer statistics;Data;Diagnosis;Disease;Geography;Incidence;Infrastructure;insight;Malignant Neoplasms;Monitor;National Cancer Institute;Patients;Population;Prevalence;SEER Program;Social Characteristics;Subgroup;Time;treatment pattern;trend

PROJECT_TITLE: SEER CORE INFRASTRUCTURE SUPPORT


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PI_NAMEs: SHRESTHA, RAJENDRA  (contact)

PROJECT_TERMS: Contracts;Extramural Activities;Research;Software Design;software development

PROJECT_TITLE: THE PURPOSE OF THIS CONTRACT IS TO PROVIDE THE OFFICE OF EXTRAMURAL RESEARCH WITH AGILE SOFTWARE DESIGN AND DEVELOPMENT SUPPORT.


ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PI_NAMEs: WIGGINS, CHARLES  (contact)


ORG_CITY: CLIFTON

ORG_STATE: VA

PHR: “This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to understand the basis of pain and enhance clinical pain management.”

PI_NAMEs: SOUNDARARAJAN, NACHIMUTHU  (contact)

PROJECT_TERMS: analytical method;assay development;authority;Biological Products;Chemicals;Chemistry;clinical pain;Clinical Research;Conduct Clinical Trials;Contracts;design;Development;Dose;Drug Kinetics;drug metabolism;Electronic Mail;Ensure;European;Experimental Designs;Feedback;Formulation;Guidelines;Helping to End Addiction Long-term;Human;International;Investigational Drugs;Lead;lead optimization;manufacture;Marketing;Medicine;member;method development;Methodology;Pain;Pain management;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacy (field);Preparation;Process;product development;programs;Recommendation;Reporting;Research Contracts;Risk;Role;Science;Services;small molecule;Speed;Teleconferences;Telephone;United States National Institutes of Health;Visit

PROJECT_TITLE: PHARMACCEUTICS FORMULATION/CHEMISTRY MANUFACTURING AND CONTROLS CONSULTING SERVICES FOR SMALL MOLECULES AND/OR BIOLOGICS


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CRANBURY

ORG_NAME: WHITE GLOBAL PHARMA CONSU

ORG_STATE: NJ

PHR: Subject matter expert support for developing therapies for neurological disorders

PI_NAMEs: WHITE, RONALD  (contact)

PROJECT_TERMS: Address;assay development;Chemistry;Clinical Research;Contractor;Data;Data Analyses;design;Development;drug development;drug discovery;Drug Kinetics;drug metabolism;Electronic Mail;Experimental Designs;Formulation;Investigational Drugs;Lead;lead optimization;Nervous System Disorder;programs;Protocols documentation;Recommendation;Reporting;Services;Telephone;therapy development;United States National Institutes of Health

PROJECT_TITLE: SUBJECT MATTER EXPERT CONSULTANT FOR DRUG METABOLISM PHARMACOKINETICS [DMPK].


PHR: Subject matter expert support for developing non-addictive therapies for pain

PROJECT_TERMS: Address;assay development;Chemistry;clinical pain;Clinical Research;Contractor;Data;Data Analyses;design;Development;drug development;drug discovery;Drug Kinetics;drug metabolism;Electronic Mail;Experimental Designs;Formulation;Helping to End Addiction Long-term;Investigational Drugs;Lead;lead optimization;Pain;Pain management;programs;Protocols documentation;Recommendation;Reporting;Services;Speed;Telephone;United States National Institutes of Health


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Persons with COPD have significant functional disability but cannot access rehabilitative treatment at hospital-based conventional pulmonary rehabilitation (PR) programs. This project will determine whether an Internet-mediated, pedometer-based walking program can increase physical activity in persons with COPD who cannot access PR, compared to usual care. This proposal has high potential to deliver an immediate solution to a pressing clinical need. The proposed research addresses Rehabilitation R&D Service's current priority area of improving disabled Veterans' health-related quality of life by reducing disease burden and maximizing functional recovery.

PI_NAMEs: MOY, MARILYN L. (contact)

PROJECT_TERMS: Accelerometer;Acute;Address;Adherence;Aerobic Exercise;Affect;American;Anxiety;Area;Behavioral;burden of illness;Cause of Death;Cessation of life;Chronic Obstructive Pulmonary Disease;Clinical;cost;Couples;deconditioning;disabled;Disease;Dyspnea;Education;efficacy evaluation;efficacy study;efficacy testing;Exercise;exercise adherence;exercise capacity;exercise intensity;exercise intervention;experience;Face;Feedback;functional disability;Geography;Goals;Guidelines;health related quality of life;High Prevalence;Home;Hospitalization;Hospitals;improved;Individual;Informal Social Control;Instruction;Internet;Intervention;Maintenance;Measures;Mediating;Medical;Medical center;Mental Depression;Monitor;Morbidity - disease rate;mortality;Motivation;online community;Outcome;Outpatients;Participant;Patients;pedometer;Persons;Physical activity;Physical Exercise;physical inactivity;programs;pulmonary function;pulmonary rehabilitation;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;Recovery of Function;Rehabilitation therapy;Research;research and development;Resources;Risk;Safety;sedentary lifestyle;Self Efficacy;Self Management;Services;Social support;standard of care;Technology;technology intervention;theories;Time;Travel;treatment as usual;United States;Veterans;Veterans Health Administration;walker;walking program;web site;web-based intervention;Writing

PROJECT_TITLE: Leveraging Technology to Address Access and Adherence to Conventional Hospital-Based Pulmonary Rehabilitation in Veterans with COPD

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Minimal information is available on the health care experiences and needs of Veterans with spinal cord injury or disorders (SCI/D) who identify as lesbian, gay, bisexual or transgender (LGBT). Veterans and Active Duty Service Members with SCI/D have access to a large comprehensive system of specialty care within the VA health care system for physical and mental health care across their lifetime. The mission of the VA SCI/D Centers is to maximize function and independence and promote quality of life, and SCI/D care covers physical functioning, wellness, medical and surgical needs, and psychosocial care provided via inpatient, outpatient and telehealth settings. However, Veterans with SCI/D who identify as LGBT may have additional health problems and concerns that are not addressed by standard SCI/D programs as VA providers may lack the experience, sensitivity, and/or knowledge to manage their specific needs. The goal of this study is to collect information from patients and providers to better understand these issues in order to offer quality care to these Veterans.

PI_NAMEs: KIRATLI, BEATRICE JENNY (contact)

PROJECT_TERMS: access disparities;active duty;Address;Age;Area;Attention;Attitude;Awareness;Behavior;Bisexual;Bladder;Body Image;Caring;Chronic;Classification;Clinical;clinical care;cohort;Communities;Complex;Country;Data;design;Development;disability;Discipline;Discipline of Nursing;Discrimination;Disease;distrust;Equity;Ethnic Origin;Exclusion;experience;Face;Female;Fright;Future;Gays;Geographic Locations;Goals;harassment;Health;health care availability;health equity;health equity promotion;health inequalities;Health Personnel;Health Professional;health service use;Health Surveys;Healthcare;Healthcare Systems;improved;Individual;injured;innovation;Inpatients;International;Intersex;Interview;Intestines;Knowledge;Lesbian;Lesbian Gay Bisexual;Lesbian Gay Bisexual Transgender;Literature;Lived experience;male;Mammography;marginalization;Medical;medical specialties;member;Mental Depression;Mental Health;Mental Health Services;Methodology;Military Personnel;Mission;Modeling;novel;Nurse Practitioners;Nurses;Operative Surgical Procedures;Outpatients;Participant;patient oriented;Patients;perceived discrimination;Personal Satisfaction;Persons;physical conditioning;Physical Function;Physicians;Pilot Projects;Policies;Population;population based;programs;Prostate;Provider;Psychologist;psychosocial;Psychosocial Assessment and Care;Publishing;Qualitative Research;Quality of Care;Quality of life;racial population;Recording of previous events;recruit;Rehabilitation therapy;Reporting;Research;Research Methodology;Research Personnel;Resistance;Resources;Risk;Rural;rural setting;Sampling;screening;service member;Services;Sex Functioning;Sexual and Gender Minorities;sexual trauma;Sexuality;social;social culture;Social Workers;Societies;Spinal cord injury;Structure;Suicide;Surgeon;Surveys;System;telehealth;Testing;Training;Training Programs;transgender;transgender men;transgender women;Trust;urban setting;Validation;Veterans;Woman

PROJECT_TITLE: Clinical care needs and experiences for patients with spinal cord injury identifying as LGBT

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Rare Diseases;Rural Health;Vector-Borne Diseases;West Nile Virus

ORG_CITY: Columbus

ORG_DEPT: ZOOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: The proposed research will generate the first ever customizable, multispecies, multiannual models of WNV transmission. This research will employ simulations to identify when and where control interventions will be most effective to reduce WNV transmission, thereby improving human and animal health. As other arthropod-borne diseases (e.g., St. Louis and Lacrosse encephalitis; Lyme disease) also show seasonal patterns of disease transmission, the results of the proposed research will enhance understanding of WNV transmission dynamics, and the ecology and evolution of multiple arthropod-borne diseases.

PI_NAMEs: MEUTI, MEGAN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Affect;Animals;arboviral disease;Arboviruses;Automobile Driving;Birds;Cities;Code;Collection;Communities;Culicidae;Data;Disease;disease transmission;Ecology;Epidemic;Evolution;falls;Goals;Health;Human;improved;Intervention;La Crosse encephalitis;Livestock;Location;Lyme Disease;mathematical model;Measures;migratory bird;Modeling;Ohio;open source;Pattern;Phylogenetic Analysis;predictive modeling;Research;Research Personnel;Resolution;Rural;rural area;Seasons;simulation;Site;Testing;Time;urban area;Urbanization;viral transmission;Weather;West Nile viral infection;West Nile virus;Work

PROJECT_TITLE: Modeling biotic and environmental drivers of seasonal West Nile virus transmission

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-U (55)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Vibrio cholerae is the etiologic agent of the severe human diarrheal disease cholera, which is responsible for severe morbidity and mortality in developing countries around the world. These proposed studies will characterize Vibrio cholerae-gut microbiome interactions in the protective mucus layer of the gut during V. cholerae infection, with the goal of better understanding how V. cholerae using intestinal mucin to promote pathogenesis and interactions with resident microorganisms and the host, and, potentially, discovering novel therapeutic and prophylactic interventions for cholera.

PI_NAMEs: HSIAO, ANSEL ;ZHU, JUN  (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Adherence;Affect;Area;Automobile Driving;Bangladesh;Carbohydrates;Carbon;Cell model;Cells;Characteristics;Cholera;cohort;Communities;Complex;Developing Countries;Diarrhea;diarrheal disease;Disease;Disease Outcome;disease phenotype;dysbiosis;enteric infection;Enzymes;Epithelial Attachment;Epithelial Cells;Epithelium;Etiology;fecal microbiota;Fibronectins;fitness;Genetic Determinism;Genetic Techniques;Genetic Transcription;Glycoproteins;Gnotobiotic;Goals;Goblet Cells;Growth;gut microbes;gut microbiome;gut microbiota;host-microbe interactions;Human;Human Characteristics;In Vitro;in vivo;Individual;Infection;Intervention;Intestines;Malnutrition;Mediating;member;Metabolic;Metabolism;Metalloproteases;Microbe;microbial community;microbiome;microbiota;microorganism;microorganism interaction;Modeling;Molecular;Morbidity - disease rate;mortality;Motility;Muc 2 protein;Mucin-2 Staining Method;mucinase;Mucins;Mucolytics;Mucous body substance;Mucous Membrane;Mus;mutant;novel therapeutics;Outcome;pathogen;Pathogenesis;Penetration;Play;Population;Population Heterogeneity;Predisposition;Process;Production;Proliferating;prophylactic;Proteins;Recurrence;resident commensals;Resistance;Resistance to infection;Resolution;response;Role;Series;Shapes;Site;Small Intestines;Source;Specificity;Structure;Surface;Testing;tissue culture;Variant;Vibrio cholerae;Vibrio cholerae infection;Virulence;Virulence Factors

PROJECT_TITLE: The role of a bifunctional mucinase in modulating personalized gut microbiota-Vibrio cholerae interactions during infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMII-U(01)]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL

ORG_ZIPCODE: SW7 3RP

PI_NAMEs: CHESLER, LOUIS  (contact);HOELDER, SWEN

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acute;age group;Alleles;Allografting;anaplastic lymphoma kinase;aspirate;Binding;Biological;Biological Availability;biomarker development;Brain;C57BL/6 Mouse;CAR T cell therapy;CD276 gene;Cell Line;Cell surface;Cells;Chemicals;Chemotherapy and/or radiation;Child;Childhood;Childhood Solid Neoplasm;chimeric antigen receptor T cells;Clinical;clinical implementation;clinical translation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;combat;cost;Coupled;CRISPR/Cas technology;Dependence;Development;Disease;drug development;Drug Targeting;drug testing;early phase clinical trial;efficacy study;Engineering;Ependymoma;Equilibrium;Evaluation;Ewings sarcoma;experimental study;Future;Genetic;Genetic Engineering;Genetic Transcription;Glioma;Glues;high risk;Human;Immunocompetent;improved;in vivo;in vivo Model;Infection;inhibitor;innovation;insight;Intervention;kinase inhibitor;Lentivirus Vector;Libraries;Malignant Childhood Neoplasm;Methods;Modeling;mortality;mouse model;Mus;mutant;MYCN gene;Neoadjuvant Therapy;Neural Crest;Neuroblastoma;neuroblastoma cell;non-genetic;novel;Nuclear RNA;Oncogenes;Oncogenic;Oncoproteins;Oral;Output;overexpression;Pathway interactions;patient derived xenograft model;patient engagement;Patient Representative;Patients;Pediatric Neoplasm;Pediatric Oncology;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;Phenotype;Phosphotransferases;pre-clinical;preclinical efficacy;preclinical evaluation;preclinical study;Preclinical Testing;Preparation;pressure;Procedures;Production;progenitor;programs;protein degradation;Protein Inhibition;protein protein interaction;Proteins;Protocols documentation;research clinical testing;Research Personnel;Resistance;Resistance development;resistance mechanism;resistance mutation;response;Risk;RNA Transport;screening;small molecule;Solid Neoplasm;structural biology;success;Survival Rate;synovial sarcoma;Testing;Therapeutic;Transgenic Model;Transplantation;tumor;Tumor Biology;tumor-immune system interactions;Validation;Variant;Virus;Xenograft procedure

PROJECT_TITLE: PROTECT - Develop therapeutics to target oncogenic drivers of solid tumours in children


NIH_SPENDING_CATS: Aging;Genetics;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE My research program aims to identify the proteins and signaling pathways that coordinate mRNA translation to prevent catastrophic proteostatic collapse. Defects in translation, RNA-protein granules, and protein degradation are associated with degenerative conditions of the nervous, muscular, and skeletal systems, cancer, diabetes, aging, and neurodevelopmental disorders. A mechanistic understanding of protein homeostasis will aid in the development of novel therapeutic strategies to improve health across the lifespan.

PI_NAMEs: MOON, STEPHANIE LYNN (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;age related neurodegeneration;Aging;Alleles;Back;Cell Physiology;Cell Survival;Cells;Collaborations;Communication;Cytoplasmic Granules;Defect;Degenerative Disorder;Degradation Pathway;Development;Diabetes Mellitus;Eukaryota;Feedback;Feeds;Genes;Genetic Diseases;Genome engineering;Goals;hallmarks of aging;Health;Human;human disease;Human Genetics;Impairment;improved;Intervention;life span;live cell imaging;Malignant Neoplasms;Maps;Mediating;Messenger RNA;Molecular;mRNA Translation;multicatalytic endopeptidase complex;muscular system;Nervous System;Neurodevelopmental Disorder;novel;novel diagnostics;novel therapeutic intervention;optogenetics;Outcomes Research;prevent;programs;Protein Biosynthesis;protein degradation;Proteins;Proteome;proteostasis;proteostasis loss;Quality Control;Regulation;Research;Research Personnel;response;RNA;Role;Signal Pathway;Skeletal system;Stress;stressor;System;Translation Initiation;Translational Regulation;Translational Repression;Translations;Ubiquitin;Work

PROJECT_TITLE: Mechanisms of Translation Regulation During Stress

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: WASHINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The proposed research aims to study the intrinsic and synaptic adaptations of pyramidal neurons in the layer V of the primary motor cortex using experimental models of Parkinson’s disease (PD). With this research, we will gain mechanistic understanding of the aberrant motor cortical activity seen in individuals afflicted by PD, providing critical insight into PD’s pathophysiology that can help us to improve the treatment of this devastating disease. Therefore, this research is relevant to the missions of the NIH and the NINDS.

PI_NAMEs: CHU, HONG-YUAN  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Affect;Age;aging related disease;Basal Ganglia;Biological Markers;biophysical techniques;Bradykinesia;Brain;Cells;cellular pathology;Clinical Research;Closure by clamp;Corpus striatum structure;Coupled;Data;defined contribution;design;Development;Disease;Disease Progression;dopaminergic neuron;Economic Burden;Electrophysiology (science);Exhibits;Experimental Models;Experimental Parkinsonism;experimental study;Functional disorder;Functional impairment;Gene Expression;Genetic;Heterogeneity;hippocampal pyramidal neuron;Impairment;improved;Individual;Induced Neurons;insight;Knowledge;Lesion;Levodopa;Link;Mission;mitopark mouse;Modeling;Molecular;Motor;motor control;Motor Cortex;motor deficit;motor disorder;Motor Skills;motor symptom;mouse model;Mus;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;neural circuit;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;novel;optogenetics;Oxidopamine;Parkinson Disease;Parkinsonian Disorders;patch clamp;pharmacologic;Physiological;Play;Population;Property;Pyramidal Tracts;Research;response;Role;Secondary to;socioeconomics;Structure;Substantia nigra structure;Synapses;Techniques;Time;tool;United States National Institutes of Health

PROJECT_TITLE: Motor cortical circuitry adaptations in experimental Parkinson's disease

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PUBLIC HEALTH RELEVANCE This study aims to contribute to the elimination of persistent tobacco use disparities among sexual and/or gender minority (SGM) groups; disparities which are worse in places with high levels of stigma against SGM people. Drawing from Empowerment Theory and building on findings from Oklahoma, we will work with community partners to (1) inform, (2) develop, and (3) pilot test the protocol for a smoking cessation intervention tailored for sexual and/or gender minority (SGM) people who live in high stigma places. Findings from this project will improve understanding of the factors that support smoking cessation for SGM people, and will develop and assess the feasibility and acceptability of a novel and scale-able intervention protocol to improve smoking cessation outcomes for SGM people who live in challenging environments that exacerbate SGM tobacco use inequities.

PI_NAMEs: DURAZO, ARTHUR ;MCQUOID, JULIA  (contact)

PROGRAM_OFFICER_NAME: HERRMANN, EVAN SULLIVAN

PROJECT_TERMS: acceptability and feasibility;Address;Adult;AIDS prevention;arm;Attitude;Automobile Driving;Behavior;behavior change;behavior test;Behavior Therapy;Behavioral;Buffers;California;Cellular Phone;Cessation of life;Characteristics;Cognitive;Communities;community empowerment;Community Participation;community partners;Country;design;Development;digital;Disease;Disparity;dissemination science;Ecological momentary assessment;empowerment;Ensure;Environment;evidence base;Exclusion;experience;Exposure to;Facebook;Feedback;follow-up;Fostering;Future;gender minority;gender minority group;Generations;Health;Health behavior change;Hour;implementation framework;improved;Individual;Inequity;informant;innovation;Integrative Therapy;Intervention;Interview;iterative design;minority stress;minority stressor;Motivation;Municipalities;National Institute of Drug Abuse;nicotine replacement;novel;Oklahoma;Outcome;Outcome Assessment;Participant;Persons;Phase;pilot test;Policies;Political Factor;Politics;Practical Robust Implementation and Sustainability Model;Process;protocol development;Protocols documentation;public health relevance;Qualifying;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Records;recruit;remote delivery;Self Efficacy;sexual minority;Site;smartphone application;Smoking;smoking abstinence;Smoking Behavior;smoking cessation;Smoking Cessation Intervention;social;social stigma;Social support;Stress and Coping;Substance Addiction;substance use treatment;success;Testing;theories;therapy adherence;therapy design;Tobacco;Tobacco use;volunteer;Work;Youth

PROJECT_TITLE: Developing An Empowerment Theory-Based Smoking Cessation Intervention for Sexual and/or Gender Minority People with Community Partners

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE Intimate partner violence (IPV) is common and particularly dangerous during the perinatal period. Healthcare- community linkages, particularly through use of community-based doulas, offer an important opportunity to support perinatal survivors and ultimately reduce IPV and improve health outcomes. Through a community- academic partnership, this study will evaluate the effectiveness of a healthcare based universal empowerment intervention delivered during prenatal visits compared with universal empowerment plus an IPV-trained doula in reducing perinatal IPV.

PI_NAMEs: MENDEZ, DARA DANEEN;RAGAVAN, MAYA  (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Administrator;Advocate;arm;Asian;Behavior;Behavior Control;Birth;Black race;Buffers;Caring;child protective service;Clinical Trials Design;Coercion;Communities;community academic partnership;community clinic;community clinical linkage;community engaged research;Community Healthcare;comparative effectiveness;Dangerousness;Data;design;Discrimination;Disparity;dosage;Economics;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;empowerment;Epidemic;Equity;Evaluation;evidence base;experience;Family Planning;Feeling;Future;future implementation;gender diverse;Harm Reduction;Health;health care service;health care settings;health equity;health equity promotion;Healthcare;healthcare community;Healthcare Systems;hybrid type 1 trial;Hybrids;Immigration;implementation determinants;implementation intervention;implementation science;implementation trial;improved;Indigenous;Infant Health;innovation;Institution;Intervention;intervention effect;Interview;intimate partner violence;Latinx;Law Enforcement;Low income;marginalization;marginalized community;marijuana use;Measures;Mediating;Mediation;Mental Depression;Methodology;Modeling;multi-racial;multidisciplinary;Neighborhoods;novel;Outcome;outcome disparities;Pacific Islander;Participant;Patient Self-Report;Patients;Pediatrics;Pennsylvania;people of color;Perinatal;perinatal cannabis use;perinatal health;perinatal period;Persons;Policy Maker;Postpartum Period;Poverty;Practical Robust Implementation and Sustainability Model;Pregnancy;Premature Birth;prenatal;Prenatal care;primary outcome;Privacy;psychologic;Public Health;Race;Randomized;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;recruit;Reporting;Reproductive Health;Research;Research Personnel;Resources;response;Safety;Schedule;school based health center;screening;secondary outcome;Self Efficacy;Services;social factors;Social support;Social Work;standard of care;structural determinants;Surveys;Survivors;System;Testing;Tobacco use;Training;Trust;Violence;Visit;Work

PROJECT_TITLE: Novel doula intervention to leverage clinic-community connections to support perinatal intimate partner violence survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-N (07)]


ORG_DEPT: PATHOLOGY

PHR: Narrative: Despite advances in the field of organ transplantation, including development of a variety of immunosuppressive medications, rejection of transplanted organs remains a major challenge and places a major burden on public health resources in the United States. In this application, we study fibrosis, the process of tissue scarring that occurs during rejection and ultimately leads to failure of the transplanted organ.

PI_NAMEs: BHOJ, VIJAY  (contact);NAJI, ALI

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: allograft rejection;Allografting;Area;Basic Science;Biological Markers;Biopsy;Bronchiolitis Obliterans;Cause of Death;Cell surface;cell type;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;Cicatrix;Clinical Trials;cohort;Collagen;Complex;coronary fibrosis;Data;Deposition;Development;Diagnostic;effective therapy;Evaluation;Evolution;experience;Extracellular Matrix;Failure;fibroblast-activating factor;Fibroblasts;Fibrosis;Functional disorder;graft failure;Health Resources;heart allograft;Heart Transplantation;Human;Image;Immune;immune cell infiltrate;Immune system;Immunosuppression;Immunotherapy;improved;Intervention;isoimmunity;Kidney;kidney allograft;Knock-in Mouse;Lead;lung allograft;Lung Transplantation;Malignant Neoplasms;Mediating;Modality;Modeling;Molecular;mouse model;Mus;myocardial injury;Natural History;Non-Malignant;novel;novel strategies;novel therapeutics;Organ;organ transplant rejection;Organ Transplantation;Outcome;Participant;Pathogenicity;Pathologic;Patients;Peptide Hydrolases;PET/CT scan;Pharmaceutical Preparations;pharmacologic;Population;post-transplant;preclinical study;prevent;Process;Profibrotic signal;protein expression;Protein Kinase;Proteomics;Public Health;Research Personnel;restoration;retransplantation;Sampling;Signal Pathway;Signaling Protein;Testing;Therapeutic;therapeutic target;Tissues;tool;Transcript;transcriptomics;transplant model;Transplant Recipients;Transplantation;tumor;tumor microenvironment;United States;Vascular Diseases;Work

PROJECT_TITLE: Fibroblast Activation Protein as a Potential Diagnostic and Therapeutic Target to Treat Chronic Allograft Dysfunction

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: To develop targeted and durable suppression against anti-drug antibody formation. Integrate a novel antibody- based receptor with physiological T cell receptor signaling (TRuC) to redirect Treg antigen specificity. Understand molecular and cellular mechanisms of suppression towards a soluble antigen.

PI_NAMEs: BISWAS, MOANARO  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Adoption;Affect;Affinity;allograft rejection;anti-CD20;Antibodies;antibody engineering;Antibody Formation;Antibody Response;Antibody Specificity;Antigens;Apoptosis;Autoimmune Diseases;Autoimmunity;Automobile Driving;B-Cell Activation;B-Lymphocytes;Biological Response Modifier Therapy;Blood Coagulation Factor;BLR1 gene;CD3 Antigens;Cell Therapy;Cells;cellular targeting;cellular transduction;chemokine receptor;Chemosensitization;chimeric antigen receptor;chimeric antigen receptor T cells;clinical translation;cytokine;Data;design;Development;Disease;Dose;Engineering;Environment;Epitopes;Equilibrium;Factor VIII;FOXP3 gene;functional outcomes;Genetic Diseases;Genetic Transcription;Glycogen storage disease type II;Hematopoietic Neoplasms;Hemophilia A;Human;Humoral Immunities;Immune;immune activation;immune modulating agents;Immune response;Immune Tolerance;immunoregulation;Immunosuppressive Agents;improved;in vivo;innovation;Interleukin-2;Intervention;Ligand Binding;Ligands;Mendelian disorder;Modeling;Molecular;Molecular Conformation;mouse model;Mus;Nature;next generation;novel;Other Genetics;Outcome;overexpression;Pathogenicity;PD-1/PD-L1;peripheral tolerance;Pharmaceutical Preparations;pharmacologic;Physiological;posttranscriptional;Pre-Clinical Model;programmed cell death ligand 1;Proliferating;receptor;Receptor Cell;Receptor Signaling;Recombinant Proteins;Recombinants;Recurrence;Regimen;Regulation;Regulatory T-Lymphocyte;Replacement Therapy;Risk;Role;Signal Transduction;Sirolimus;Site;Specificity;Structure of germinal center of lymph node;Supplementation;Surface;T cell therapy;T-Cell Activation;T-Cell Proliferation;T-Cell Receptor;Testing;Translating;Transplantation;Transplantation Tolerance;Treatment Efficacy;treatment strategy

PROJECT_TITLE: Optimizing precision Treg therapy to control anti-drug antibodies

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Immunotherapy;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Inflammation in the placenta can cause harm to the developing baby and to future pregnancies; yet, often there is no explanation as to why it occurred. Our goal is to uncover the interactions between the mother’s immune system and the fetal placenta that are altered, resulting in a chronic villitis of unknown etiology diagnosis at birth. Understanding these interactions can lead to new ways to diagnose and treat this damaging inflammation, leading to improved pregnancy and infant outcomes.

PI_NAMEs: ENNINGA, ELIZABETH ANN LIESER (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: adaptive immune response;Address;Adrenal Cortex Hormones;alpha-beta T-Cell Receptor;Anti-Inflammatory Agents;Antigen Targeting;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Aspirin;Biological;Biological Markers;Biological Products;Birth;Blood;Cell Death;Cell Line;Cell Physiology;Cell-Mediated Cytolysis;Cells;checkpoint receptors;chemokine;Chorionic villi;Chronic;Clinical;clinically significant;Clone Cells;Cloning;comparison control;cytokine;cytotoxicity;Data;Development;Diagnosis;Disease;Disease Outcome;embryo/fetus antigen;Enrollment;Ensure;Epitopes;Etiology;Exposure to;fetal;Fetal Growth Retardation;Fetus;Future;Goals;Immune;immune checkpoint;immune modulating agents;Immune response;Immune Tolerance;Immunologics;Immunology;improved;in utero;Infant;infant outcome;Infection;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;innovation;insight;Institution;Interleukin-1 beta;Intravenous Immunoglobulins;Ligands;Major Histocompatibility Complex;maternal immune system;Maternal-Fetal Exchange;Mediating;Morbidity - disease rate;mortality;multidisciplinary;Necrosis;neurodevelopment;novel;novel strategies;nuclear factors of activated T-cells;Outcome;Pathogenesis;Pathology;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;Phenotype;Placenta;Plasma;Population;Pregnancy;Pregnancy Outcome;prevent;Prevention;prospective;receptor;receptor expression;Recurrent disease;Reporter;Resources;response;Role;Sampling;screening;Severities;Severity of illness;Signal Transduction;Source;Specificity;stillbirth;Stromal Cells;T cell infiltration;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;therapeutic evaluation;Tissues;TNF gene;trophoblast;Up-Regulation;Villus;Viral;Virus;Virus Diseases

PROJECT_TITLE: Defining T cell-placenta immune mechanisms in chronic villitis

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Asthma;Lung

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Patients with asthma have persistent respiratory problems because of inflammation in their airways. This research will investigate how the interaction of immune cells and environmental allergens causes immune responses and inflammation in the airways. Successful completion of this project will provide new prevention and therapeutic strategies for asthma and related airway diseases.

PI_NAMEs: KITA, HIROHITO  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Acute;Address;Adult;airborne allergen;Airway Disease;airway inflammation;Allergens;Allergic Disease;Animals;Antigens;arm;Asthma;CD4 Positive T Lymphocytes;Cell Physiology;cell type;Cells;Chronic;chronic inflammatory disease;Cues;cytokine;Development;Diagnosis;Disease;Environment;environmental allergen;eosinophil;Epithelium;experience;Exposure to;Financial Hardship;Functional disorder;Genes;genetic approach;Genetic Transcription;genome wide association study;germ free condition;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;House mice;Human;Human body;IL2RB gene;Immune;Immune response;Immunity;Immunologic Memory;Immunologics;Inflammation;Interleukin-13;Interleukin-5;Interleukins;Knowledge;Laboratory mice;Lung;Lymphocyte;Lymphocyte Count;Lymphoid Cell;Mediating;Medical;Memory;Microbe;microbial;mouse model;Mus;novel;novel strategies;pathogen;Patients;Physiological;Play;Prevention;Process;Research;Research Support;Resources;respiratory;Respiratory Tract Diseases;response;Rodent;Role;RORA gene;Single Nucleotide Polymorphism;Source;Structure of parenchyma of lung;Technical Expertise;Th2 Cells;Therapeutic;tissue resident memory T cell;tool;TSLP gene;Work;Zebrafish

PROJECT_TITLE: Roles of Group 2 Innate Lymphoid Cells in Asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The proposed research is relevant to public health because many clinical and experimental vaccines fail to generate long-lasting humoral immunity, which is a key to preventing infection in the long term. The proposed study’s expected result is an in-depth understanding of the transcriptional regulation generating long-lasting humoral immunity that will be instrumental in identifying targets for pharmacological intervention and designing an immunomodulator/vaccine adjuvant that can enhance the duration of long-lasting humoral immunity upon vaccination. Thus, the proposed research is relevant to the NIH’s mission to develop fundamental knowledge that will help to reduce the burdens of human disease and disability.

PI_NAMEs: ROY, KOUSHIK  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Adoptive Transfer;Affinity;Antibodies;Antibody Affinity;Antigens;B cell differentiation;B Cell Proliferation;B-Cell Antigen Receptor;B-cell receptor repertoire sequencing;B-Lymphocytes;Binding;Cell Differentiation process;Cell Surface Receptors;Cells;Cellular biology;Clinical;Communicable Diseases;Data;design;Development;dimer;disability;Disease;Flow Cytometry;Fluorescence;Generations;Genes;Genetic;Genetic Transcription;Goals;Hemagglutinin;human disease;Humoral Immunities;I-kappa B Proteins;Immunity;Immunization;Immunize;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;Immunomodulators;improved;in vivo;Infection;Infection prevention;Influenza;influenza infection;influenza virus vaccine;influenzavirus;inhibitor;innovation;insight;Intervention;intravital imaging;Knockout Mice;Knowledge;Laboratories;Mediating;Memory B-Lymphocyte;Mission;Modeling;Mus;Mutate;neutralizing antibody;NF-kappa B;pathogen;pharmacologic;Phenotype;Physiological;Plasma Cells;preference;programs;Property;Public Health;Receptor Signaling;Reporter;Research;response;Role;Signal Transduction;Specificity;Structure of germinal center of lymph node;success;Testing;TNFRSF5 gene;Transcriptional Regulation;transcriptome sequencing;Translating;United States National Institutes of Health;Vaccination;vaccination strategy;Vaccine Adjuvant;vaccine response;vaccine-induced immunity;Vaccines;Viral Load result;Viral Pathogenesis;Work

PROJECT_TITLE: Role of the NFkB signaling network in generating memory B cell and long-lived plasma cell

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative In addition to the significant social, psychological, and physical tolls of eosinophilic gastrointestinal diseases (EGIDs), the annual healthcare burden of eosinophilic esophagitis alone is estimated to reach $1.4 billion. The prevalence of EGIDs in children and adults is increasing worldwide, yet the mechanisms whereby eosinophils contribute to pathology or pathogenesis of disease is not known. The overall goals of this project are to identify functions of intestinal tissue eosinophils that impact GI diseases and to define core cellular processes that govern these functions. Completion of this proposal will provide fundamental insights to speed the development of precision eosinophil-modulating therapies to treat EGIDs and other GI diseases associated with eosinophilia.

PI_NAMEs: SPENCER, LISA ANN (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Abdominal Pain;Abscess;Adrenal Cortex Hormones;Adult;Affect;Allergens;Allergic;Allergic inflammation;Biological;Biology;Biopsy;Cell Physiology;Cells;Child;Chronic;cytokine;Data;Deglutition Disorders;density;Development;Diarrhea;Disease;disease model;Disease Outcome;eosinophil;Eosinophilia;Eosinophilic Esophagitis;eosinophilic gastroenteritis;Eosinophilic Gastrointestinal Disease;Epithelium;Exhibits;Flow Cytometry;food allergen;Food Hypersensitivity;Functional disorder;functional outcomes;Funding;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal tract structure;Genetic;genetic approach;Genetic Transcription;Goals;Health;healthcare burden;Heterogeneity;high dimensionality;Histologic;Home;Homeostasis;Human;human tissue;Immune;Immune response;Immunobiology;Impairment;improved;In Situ;in vivo;Inflammation;Inflammatory;Inflammatory Response;Inhalation;insight;Intestines;Knowledge;Large Intestine;Leukocytes;Lung;Maps;Mediating;microbial host;microbiome;migration;Modeling;Morphology;mouse model;Mucous Membrane;Mus;notch protein;novel;Nutrient;Oral;Organ;overexpression;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Phenotype;Pilot Projects;Precision therapeutics;Prevalence;prevent;protein biomarkers;psychologic;Publishing;Reflux;Regulation;restoration;Role;scaffold;Signal Transduction;Small Intestines;social;spectrograph;Speed;Symptoms;Therapeutic;therapeutic target;Tissues;tool;transcriptome;Translating;uptake;Villus;Vomiting

PROJECT_TITLE: Eosinophil functions in allergic gastrointestinal diseases


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Lung;Machine Learning and Artificial Intelligence;Radiation Oncology

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: According to NOT-CA-24-015, a project narrative is not applicable.

PI_NAMEs: SAMEI, EHSAN ;YANG, XIAOFENG  (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: 3-Dimensional;Address;Administrative Supplement;Anatomy;Area;Big Data Methods;cancer site;Characteristics;Clinical;Clinical Research;Cloud Computing;cone-beam computed tomography;cost efficient;Data;deep learning;design;Development;digital assessment;digital twin;Dose;empowerment;Ensure;falls;Funding;heuristics;Image;image guided;improved;innovation;insight;Interdisciplinary Study;interest;Lung;Machine Learning;Medical;Methods;Modality;model design;Modeling;Monte Carlo Method;Motion;novel;Outcome;parent project;Parents;participant enrollment;Patients;Performance;Physicians;Precision therapeutics;preemptive intervention;Protocols documentation;Radiation Dose Unit;Radiation Oncology;Radiation therapy;reconstruction;Research;Resources;respiratory;response;Roentgen Rays;Scheme;success;Technology;temporal measurement;Time;Training;treatment comparison;Treatment outcome;trend;tumor;tumor behavior;tumor progression;Update;Variant;X-Ray Computed Tomography

PROJECT_TITLE: Personalized Digital Twin for Precise Lung Stereotactic Body Radiation Therapy (SBRT)

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Prevention

ORG_CITY: ATHENS

ORG_NAME: NYTRICX INC.

PHR: PA-20-272, Nytricx, Inc., STTR Phase II – Supplemental - Narrative “Ultra-low Fouling and Anti-infective and Anti-thrombotic Nitric Oxide Releasing Intravascular Catheters" (Parent Grant 2 R42 HL149595-02A1) The objective of the supplemental funding request is to support catheter manufacturing to reinforce the Nytricx intravascular silicone-based catheter with nylon monofilament such that the catheter withstands power injection up to 300 PSI for diagnostic CTs.

PI_NAMEs: SHEBUSKI, RONALD J. (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Adsorption;Affect;Anti-Infective Agents;base;Catheters;Computer Assisted;computer-assisted diagnostics;Coupled;Diagnostic;Environment;Funding;Gases;Infection;Injections;manufacture;Microbial Biofilms;Nitric Oxide;Nitric Oxide Donors;Nylons;parent grant;Phase;Polymers;pressure;prevent;Prevention;Property;Protein Structure Initiative;Proteins;Silicones;Small Business Technology Transfer Research;Technology;Thrombosis;thrombotic;tomography


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: NUTRITION

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE Not having enough healthy food to eat during pregnancy can lead to health disparities for both moms and babies, so some healthcare systems are offering “medically tailored groceries”—foods chosen by a nutritional professional and available to be picked up for several weeks or months-- to address this. Sometimes, lack of transportation or other challenges can make it hard for families to take advantage of MTG. Our study helps us understand if delivering MTG to a family’s home, as well as adding nutrition and cooking education, can improve outcomes for moms and babies.

PI_NAMEs: BORAWSKI, ELAINE A. (contact);GLENN, ALISSA

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Address;Adopted;arm;Behavior;Behavioral;Birth;Birth Weight;Black race;Child;Chronic;Chronic Disease;Cities;Clinic;Clinical;clinical care;community academic partnership;community clinic;community partnership;Consensus;Consumption;cooking;County;Data;Death Rate;delivery complications;design;Diabetes Mellitus;dietary;Discipline of obstetrics;Discrimination;disorder prevention;disparity reduction;dosage;Eating;Education;effectiveness testing;Environment;Equipment;Equity;evidence base;Family;Fatigue;Fetal health;Food;Food Access;food insecurity;food preparation;food security;fruits and vegetables;Funding;Future;Gestational Age;Gestational Diabetes;Glycosylated hemoglobin A;Goals;Government;Health;Health behavior and outcomes;health disparity;Health Food;Health system;healthcare community;Healthcare Systems;high risk;High-Risk Pregnancy;Home;Housing;Hypertension;improved;improved outcome;income disparities;Individual;Infant Mortality;Institution;Intake;Intervention;Intervention Trial;Length of Stay;lens;Life;Link;literacy;Low income;Malignant Neoplasms;Marketing;Maternal Health;Mediating;Medicaid eligibility;Medical;Medical center;medication compliance;Medicine;Mental Health;Mission;Modeling;Nutrient;nutrition;Nutritional;Ohio;Outcome;Parents;Pathway interactions;Patient Care;patient population;Patients;Persons;postnatal;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnant;Pregnant Women;premature;Premature Infant;Prenatal care;Prenatal Nutrition;Prevention;Process;programs;Provider;racial disparity;Randomized;Recommendation;Role;Sample Size;Security;Self Efficacy;skills;social;social health determinants;social stigma;Special Supplemental Nutrition Program for Women, Infants, and Children;Stress;success;System;tool;Transportation;treatment arm;treatment planning;United States;University Hospitals;uptake

PROJECT_TITLE: The Role of Medically Tailored Groceries in Mitigating Food Insecurity and Improving Pregnancy Outcomes through Clinic-Community Partnerships


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: Project Narrative Men and women who inject drugs and living with HIV are less likely to adhere to antiretroviral therapy (ART) or continue with opioid substitution therapy. To address the paucity of interventions to improve these outcomes, the proposed project will develop and assess preliminary impact of a family-engaged support intervention, called Project Vuselela, led by peer navigators. ART adherence and OST continuation are the primary outcomes. Findings will provide essential information for related family-engaged interventions globally.

PI_NAMEs: DANIELS, JOSEPH  (contact);MANYUCHI, ALBERT EDGAR

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Address;Adherence;African;AIDS prevention;antiretroviral therapy;Awareness;Behavior;behavior change;Biometry;Caring;Cities;Clinic;Clinical;Cognitive;Communities;community advisory board;Country;Decision Making;Dimensions;Drug usage;Drug user;Effectiveness;efficacy trial;Ensure;Evidence based practice;experience;Family;Family member;Family Practice;family support;Feedback;Goals;Guidelines;Harm Reduction;Health Services Accessibility;HIV;HIV/TB;implementation measures;implementation protocol;improved;improved outcome;Individual;Infrastructure;Injecting drug user;injection drug use;interest;Intervention;intervention mapping;Intervention Studies;Intervention Trial;Interview;Joints;Low income;Measures;men;Modeling;Motivation;Needs Assessment;Opioid replacement therapy;Outcome;Participant;peer;Persons;Pharmaceutical Preparations;Pilot Projects;pilot test;Play;Population;Population Density;preference;Prevalence;primary outcome;Procedures;process evaluation;programs;Randomized;Randomized, Controlled Trials;recruit;Research;research study;response;Role;service providers;Services;skills;social;South Africa;South African;standard of care;successful intervention;Support System;theories;therapy adherence;therapy design;therapy development;therapy outcome;Time;Training;Trauma;treatment adherence;Treatment outcome;trend;trial design;urban setting;Viral;Woman;Work

PROJECT_TITLE: An intervention integrating peer navigation and family engagement to improve ART and OST adherence in South Africa


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Target-directed microRNA degradation (TDMD) is a mechanism by which endogenous target RNAs degrade specific microRNAs to modulate gene expression. Treatment of T-cell acute lymphoblastic leukemia (T-ALL) cells by glucocorticoid induces apoptosis through BIM expression, which can lead to microRNA-221/222 degradation via TDMD. We will examine how microRNA-221/222 degradation may contribute to T-ALL apoptosis, globally profile TDMD events and explore the role of TDMD during glucocorticoid-treatment of T-ALL.

PI_NAMEs: LICHT, JONATHAN D.;XIE, MINGYI  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute T Cell Leukemia;acute T-cell lymphoblastic leukemia cell;Adenosine;Affect;aged;Apoptosis;Apoptotic;Base Pairing;Binding;Biochemical;bioinformatics pipeline;Biology;cancer cell;cancer diagnosis;Cancer Intervention;cancer therapy;Cell Death;Cell Line;Cell Membrane Permeability;Cells;chemotherapy;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collecting Cell;combat;CRISPR screen;CRISPR/Cas technology;crosslink;Data Set;Degradation Pathway;Development;Dexamethasone;differential expression;DNA;Elements;Enzymes;Event;gene discovery;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;genetic information;Genetic Transcription;genome-wide;Glucocorticoid-induced apoptosis;Glucocorticoids;Hematopoietic Neoplasms;Hybrids;improved;Induction of Apoptosis;innovation;leukemia;Leukemia Acute Lymphoblastic Chemotherapy;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mediating;Messenger RNA;MicroRNAs;mitochondrial membrane;Mixed B- and T-Cell Leukemia;Molecular;Mus;mutant;Mutate;Mutation;Mutation Analysis;Names;novel;novel therapeutics;Nucleotides;Oncogene Activation;Oncogenic;Pathologic;Pathway Analysis;Pathway interactions;patient derived xenograft model;Patients;Persons;Physiological;prevent;pro-apoptotic protein;Process;Proteins;Protocols documentation;Regulation;Repression;Resistance;resistance mechanism;response;RNA;Role;Sampling;Sequence Analysis;Small RNA;standard care;Steroids;System;Tail;Therapeutic Intervention;therapeutic RNA;Transcript;transcriptome sequencing;Translating;Translations;Tumor Suppressor Proteins;ubiquitin ligase;Untranslated Regions;Untranslated RNA;Uridine;Validation;Xenograft Model

PROJECT_TITLE: Exploring microRNA degradation in T-cell acute lymphoblastic leukemia

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: CHAMPAIGN

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: RELEVANCE (See Instructions): Results from our surveillance sampling, AdV phylodynamics, advanced computational tools and predictive transmission Is will provide knowledge of disease transmission in a spillover hotspot. Our protocol will demonstrate how tools and predictive models will provide knowledge of disease transmission pathways in complex environments. The proposed work will enable future research targeting dangerous but rarepathogens, such as single-stranded RNA viruses of zoonotic origin (e.g., Ebola). Transmission d ynamics of viral pathogens will inform proactive health and conservation policies to i reduce cross-species disease transmission at a time of increasing climate change and human-wildlife interactions.

PI_NAMEs: STUMPF, REBECCA  (contact)

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TERMS: Address;Adenoviruses;Affect;Africa;African;Animals;anthropogenesis;Area;Biodiversity;Bioinformatics;bioinformatics tool;Biometry;Catarrhine;Cattle;Chickens;climate change;Communities;Complex;Computer Analysis;computerized tools;Dangerousness;Data;Decision Making;density;Disease;Disease Outbreaks;Disease Pathway;disease transmission;DNA sequencing;Domestic Animals;Ebola;Environment;epizootic;fly;Genetic;Genome;Genomics;Grain;Health;Health Benefit;Human;improved;Insecta;insight;Instruction;Integration Host Factors;Knowledge;Modeling;Molecular;Monkeys;next generation;next generation sequencing;nonhuman primate;Order Coleoptera;Organism;pathogen;pathogenic virus;Pathway interactions;Phylogenetic Analysis;Phylogeny;Policies;Population;predictive modeling;Prevalence;prevent;Protocols documentation;Public Health;Quality of life;Research;RNA Viruses;Route;Rural;Sampling;Soil;Source;surveillance data;Targeted Research;Techniques;Ticks;Time;tool;Training;transmission process;Uganda;Variant;Viral;viral transmission;Virus;Water;Wild Animals;Work;Zoonoses

PROJECT_TITLE: Pathogen Transmission Dynamics among Wildlife and Human Settlements in Rural Western Uganda


ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Narrative Antibiotics severely alter the gut microbiome producing a state of microbial imbalance called dysbiosis. How dysbiosis affects cancer progression is largely unknown. This project will expand our understanding of the crosstalk between the gut microbiome, the tumor microenvironment, and cellular immunotherapy during antibiotic-induced dysbiosis.

PI_NAMEs: DINGS, RUUD P.M. (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Acceleration;Affect;Ampicillin;Antibiotic Therapy;Antibiotics;Blood Vessels;Cancer Patient;Cell Adhesion Molecules;Cellular immunotherapy;chimeric antigen receptor T cells;Ciprofloxacin;Clinic;Clinical;combat;commensal bacteria;Congenic Mice;Data;Defect;Development;Distal;Dorsal;dysbiosis;Effectiveness;effector T cell;Endothelial Cells;Endothelium;Extravasation;fecal transplantation;fighting;Flow Cytometry;Fluorescence Microscopy;Foundations;Frequencies;Future;Gastrointestinal tract structure;Goals;gut microbiome;gut microbiota;Homeostasis;Human;Image;Immune;Immune checkpoint inhibitor;Immune system;immunogenic;Immunosuppression;Immunotherapy;improved;Incidence;Infection;Intercellular adhesion molecule 1;intravital microscopy;Investigational Therapies;Knowledge;Leukocyte Trafficking;Leukocytes;Malignant Neoplasms;MEL Gene;Melanoma;Metronidazole;microbiome;Modeling;Molecular;Morbidity - disease rate;Mus;Neomycin;Nude Mice;optoacoustic tomography;pathogenic bacteria;Patients;Publishing;response;rRNA Genes;Solid Neoplasm;success;Supplementation;T cell infiltration;T cell therapy;T-Lymphocyte;Therapeutic;therapy development;Time;TNF gene;trafficking;transcriptome sequencing;Treatment Efficacy;Trimethoprim-Sulfamethoxazole;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Suppression;unpublished works;Vancomycin;Work

PROJECT_TITLE: Improvement of cellular immunotherapy during dysbiosis- Resubmission

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Radiation Oncology;Rare Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Radiation therapy for the clinical management of brain tumors and metastases is linked with severe cognitive decline and neuroinflammation in cancer survivors. We hypothesize that radiation-induced aberrant activation of the glial complement cascade play a causal role in development of cognitive impairments. This proposal will address glial complement activation mechanism and translationally feasible intervention to curtain this unmet medical need.

PI_NAMEs: ACHARYA, MUNJAL M (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Ablation;Acute;Address;Adult;Aftercare;Alzheimer's Disease;Anaphylatoxins;Animals;antagonist;Apoptotic;Astrocytes;astrogliosis;Behavior assessment;Biopsy;blood-brain barrier permeabilization;Brain;brain dysfunction;Brain Injuries;Brain Neoplasms;C5a anaphylatoxin receptor;cancer invasiveness;Cancer Survivor;cancer therapy;Cells;Chronic;Clinical;Clinical Management;clinically relevant;Cognition;Cognitive;Cognitive deficits;cognitive function;Complement;Complement 1q;complement 1q receptor;Complement 3a;Complement 5a;Complement Activation;complement system;Complex;Cranial Irradiation;cytokine;Data Set;design;Development;Dose;effectiveness testing;Epilepsy;Foundations;Gene Expression Profile;Genes;Genetic;glial activation;Glioma;Gliosis;Hour;Human;Hypertrophy;Immune signaling;Immunocompetent;Impaired cognition;Impairment;improved;Inflammation;Intervention;knock-down;Link;link protein;Malignant neoplasm of brain;Malignant neoplasm of central nervous system;Malignant Neoplasms;Mediating;Mediator;Medical;Metastatic malignant neoplasm to brain;Microglia;Molecular;mouse model;Mus;Nerve Degeneration;Neurobiology;neurogenesis;neuroinflammation;neuroprotection;neurotransmission;novel;Oral;Outcome Study;Oxidative Stress;Patients;pediatric low grade glioma;pharmacologic;Play;Production;Prognosis;Proteins;Quality of life;Radiation;Radiation therapy;receptor;Receptor Inhibition;Reporting;response;restoration;Rodent Model;Role;Signal Transduction;standard of care;stem cell proliferation;Synapses;synaptic pruning;temozolomide;Testing;Therapeutic;Therapeutic Intervention;therapy design;Tissues;TLR4 gene;Transgenic Organisms;treatment response;tumor;tumorigenic

PROJECT_TITLE: Glial immune signaling in radiation-induced brain injury

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: CHICAGO

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Immunotherapies hold immense potential to provide cures for many cancers and metastatic disease, but the complexity of activating and sustaining anti-tumor immune responses will necessitate combinatorial treatment regimes and a better understanding of how the tumor microenvironment (TME) affects response. Here we develop a in vitro model of the tumor-immune circuit which allows precise control over spatial, molecular, cellular, and mechanical aspects of the TME that affect response to immunotherapy, and use it for both mechanistic studies as well as high-throughput predictive screening of immune therapies in a tumor- or patient- specific manner.

PI_NAMEs: SWARTZ, MELODY ANN (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Address;Adverse event;Affect;anti-tumor immune response;Binding;Biological Models;Biomechanics;Breast Cancer Model;cancer immunotherapy;cancer type;cell killing;cell type;Cells;Characteristics;chemokine;Chemosensitization;chimeric antigen receptor T cells;Collaborations;Collagen;Combination immunotherapy;combinatorial;Communication;Complement;Complex;cost;cytokine;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Development;Devices;Disease;draining lymph node;Engineering;Environment;Exclusion;Exhibits;experimental study;extracellular;Extracellular Matrix;Face;flexibility;Goals;high throughput screening;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunomodulators;immunoregulation;Immunosuppression;Immunotherapy;immunotoxicity;improved;In Situ;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;insight;interest;interstitial;Leukocytes;Lymph;Lymphangiogenesis;Lymphatic;Lymphatic Endothelial Cells;Malignant Neoplasms;Maps;Mechanics;Mediator;Melanoma;Metastasis Suppression;Minority;Modeling;Molecular;Morphology;mouse model;Mus;Nature;neoantigens;Neoplasm Metastasis;neoplastic cell;neutrophil;novel;novel therapeutic intervention;Outcome;parallelization;Patients;Perfusion;personalized approach;Play;pre-clinical;Predictive Value;Primary Neoplasm;Process;Pump;response;Role;screening;Signal Transduction;spatial relationship;Stratification;System;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;Testing;tool;Transfection;tumor;tumor heterogeneity;tumor immunology;tumor microenvironment;tumor-immune system interactions;Vascular Endothelial Growth Factor C

PROJECT_TITLE: Probing cellular, molecular and biomechanical barriers to immunotherapy in the tumor microenvironment with organotypic in vitro models of the tumor-lympho-immune interface

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Rural Health

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Narrative The diversification of genomics research cohorts is a national priority intended to accelerate research and improve individualized prevention, treatment and care. Concrete, tailored strategies are needed to ethically engage various individuals living in the rural South to promote equitable access to genomic discovery and translation. Thus, the proposed study leverages a multi-disciplinary team and stakeholder-engaged approach to ultimately identify best practices for community translation of genomic discoveries.

PI_NAMEs: FLETCHER, FAITH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, DAVE J

PROJECT_TERMS: Acceleration;Alabama;Back;biobank;Caring;cohort;Collection;Communication;Communities;community engagement;County;Data;Deep South;Education;Equity;Ethics;evidence base;Family;Family history of;Feedback;follow-up;genetic information;genetic testing;Genomics;Guidelines;Healthcare;Hospitals;improved;Individual;individualized prevention;Informed Consent;Institutional Review Boards;Knowledge;Learning;Medical;Medical History;medically underserved population;Methods;multidisciplinary;Occupations;Phase;precision medicine;preference;Privacy;Process;Recording of previous events;recruit;Research;Research Personnel;Research Priority;research study;Resources;Rural;rural dwellers;Rural Population;social;Structure;Technology;translational genomics;Translations;Trust;Underrepresented Populations;underserved community

PROJECT_TITLE: Developing Evidence-Based Guidance for Engaging Rural Residents in the Deep South in Genomics Research: A Stakeholder-Driven Perspective


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cardiovascular;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative We have identified 2.5-fold higher prevalence of doxorubicin-induced cardiotoxicity (DIC) in African American (AA) than European American survivors yet the biological basis of this racial disparity in DIC is poorly understood. We will use human induced pluripotent stem cell-derived cardiomyocytes derived from AA survivors to discover novel genetic variants for DIC and validate the mechanisms by which these genetic variants influence this potentially fatal drug complication. This knowledge will provide clinicians with a validated genomic tool to predict if a patient will experience DIC and a route to discover genotype-specific cardioprotective drugs.

PI_NAMEs: BURRIDGE, PAUL W. (contact);SAPKOTA, YADAV

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TERMS: Adolescent;Adult;Affect;African American;Age;Algorithms;alternative treatment;American;Anthracycline;Area;ATAC-seq;Biochemical;Biological;Biological Assay;Blastoma;Body mass index;cancer diagnosis;Cancer Patient;Candidate Disease Gene;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Cardiotoxicity;chemotherapy;Chest;Child;childhood cancer survivor;Chromatin;Clinical;clinical application;Clinical Data;clinical risk;cohort;Common Terminology Criteria for Adverse Events;Complication;Correlation Studies;Coupled;CRISPR/Cas technology;Cryopreservation;Data;Detection;differential expression;Dose;Doxorubicin;Drug Prescriptions;Drug usage;Enhancers;epigenome;Etiology;European;experience;Exposure to;Gene Expression;Genes;Genetic;Genetic study;genetic variant;Genome;genome editing;genome sequencing;genome wide association study;genomic predictors;genomic tools;Genomics;Genotype;Heart failure;Heart Transplantation;Hematologic Neoplasms;High Prevalence;Human;human induced pluripotent stem cells;human model;In Vitro;Individual;induced pluripotent stem cell derived cardiomyocytes;innovation;interest;Knowledge;leukemia;Linkage Disequilibrium;Lymphoma;Malignant Childhood Neoplasm;Maps;Mediating;member;Metabolism;Methodology;Modality;novel;Oncologist;Online Systems;Participant;Pathway interactions;Patients;pediatric patients;Performance;Pharmaceutical Preparations;Phenotype;Physiological;Predisposition;prevent;Process;promoter;Quantitative Trait Loci;racial disparity;Radiation therapy;RARG gene;Regulatory Element;Research;response;Risk;Risk Factors;risk prediction;risk prediction model;Risk Reduction;RNA Splicing;Role;Route;Saint Jude Children's Research Hospital;Sampling;Sarcoma;sex;Single Nucleotide Polymorphism;Solid;Survivors;Time;tool;transcriptome;transcriptome sequencing;Translating;user-friendly;Validation;Variant;whole genome;Work

PROJECT_TITLE: Predicting and Preventing Chemotherapy-Induced Cardiotoxicity in African American Children


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: NARRATIVE MDM2 and its numerous isoforms are key regulators of the expression and function of the p53 gene, a critical tumor suppressor that prevents inappropriate cell growth and proliferation. The proposed research will study the molecular connection between DNA damage, MDM2 isoform switching, p53, and cancer. Unraveling this pathway could lead to the discovery of novel therapeutic intervention points and thus be a crucial stepping-stone for cancer drug discovery.

PI_NAMEs: CHANDLER, DAWN S (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Adult;Alanine Transaminase;Alternative Splicing;Antineoplastic Agents;Astrocytoma;Automobile Driving;Binding;Binding Proteins;Bioinformatics;Biological Assay;Biology;Biophysics;Breast;Cancer Biology;cancer therapy;cancer type;cell growth;Cell Line;Cell Proliferation;cell type;Cells;Cellular Stress;Chemistry;chemotherapeutic agent;Childhood Glioma;combinatorial;Complex;Coupled;Data;design;Disease;DNA Damage;Dominant-Negative Mutation;drug discovery;Engineering;Event;Excision;exon skipping;Exons;Future;gene-editing approach;Generations;Genetically Engineered Mouse;Genome;Genotoxic Stress;genotoxicity;Glioma;Goals;High-Throughput Nucleotide Sequencing;Human;In Vitro;industry partner;Knowledge;Length;liposarcoma;Lung;Lymphoma;Malignant Childhood Neoplasm;Malignant Neoplasms;MDM2 gene;Measures;Mechanics;Mediating;Methodology;Methods;MicroRNAs;Modality;Modeling;Molecular;mouse model;mRNA Precursor;Mus;Mutation;novel;novel therapeutic intervention;Nuclear;Nuclear Protein;Nuclear RNA;Oligonucleotides;Oncogenic;Outcome;Ovary;overexpression;Pathway interactions;Pharmacologic Substance;Phenotype;Play;Positioning Attribute;prevent;Primary Neoplasm;Property;Protein Isoforms;Proteins;Publishing;Regulation;Regulatory Element;Repression;Research;response;Rhabdomyosarcoma;RNA;RNA Biochemistry;RNA metabolism;RNA Processing;RNA Sequences;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Stress;System;Technology;Testing;Therapeutic;Therapeutic Intervention;therapy design;TP53 gene;tumor;tumor progression;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;Variant;Viral;Work;Xenograft procedure

PROJECT_TITLE: Mdm2 Alternative Splicing in DNA Damage and Cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Cancer;Chronic Pain;Neurodegenerative;Neurosciences;Orphan Drug;Ovarian Cancer;Pain Research;Peripheral Neuropathy;Prevention;Rare Diseases;Women's Health Research

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Ovarian cancer affects only women for which cisplatin is a commonly used chemotherapeutic drug but it causes neurotoxicity leading to painful neuropathy, cognitive decline, called `chemobrain' and alterations in gait with increased propensity to fall/fractures, which may continue even after the discontinuation of treatment. We hypothesize that the activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase plays a critical role in cisplatin-induced damage to the nervous system and that inhibition of these pathways will attenuate cisplatin-induced neurotoxic side effects in female mice with ovarian cancer. We expect that the results of our study will lead to the development of novel therapeutics to reduce the debilitating sequelae of cisplatin in women with ovarian and other cancers.

PI_NAMEs: BOTA, DANIELA ANNENELIE (contact);GUPTA, KALPNA

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Adverse effects;Affect;Aftercare;Alzheimer's Disease;anticancer activity;Antineoplastic Agents;Attention;Attenuated;attenuation;Axon;axon injury;Behavioral;Bioenergetics;blood-brain barrier crossing;Brain;Breast;Breast Cancer Model;C57BL/6 Mouse;Cancer Model;Cancer Patient;cancer therapy;Cell Line;chemobrain;chemotherapeutic agent;chemotherapy;Chemotherapy-induced peripheral neuropathy;Cisplatin;Clinical;Clinical Trials;Cognitive;Cognitive deficits;cognitive testing;Data;Dendritic Spines;density;Development;Diagnosis;disability;Disease Progression;DNA Damage;Dose;druggable target;Electrophysiology (science);Epithelial ovarian cancer;Excitatory Synapse;executive function;experience;falls;FDA approved;Female;Fracture;Gait;health disparity;Hippocampus;Impaired cognition;Impairment;improved;In Vitro;in vivo;Individual;Induced Neurons;Induction of Apoptosis;Inflammation;information processing;inhibitor;Injury;Intervention;Kidney;kinase inhibitor;Length;male;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;MAPK8 gene;Memory;men;Mitochondria;Mitochondrial DNA;Mitogen-Activated Protein Kinase Kinases;Mitogen-Activated Protein Kinases;Mitogens;Molecular;Morphology;Motor;multidisciplinary;Mus;N-terminal;Nerve;Nerve Fibers;nerve stem cell;Nervous System;neural;Neurologic;neuron apoptosis;Neurons;Neuropathy;neurotoxic;neurotoxicity;neurotransmission;novel;novel strategies;novel therapeutics;Nuclear;Numbness;ototoxicity;Ovarian;Oxidative Stress;Oxygen;p38 Mitogen Activated Protein Kinase;Pain;painful neuropathy;Painful Paresthesias;Pathway interactions;patient mobility;Patients;Performance;Peripheral;Peripheral Blood Stem Cell;peripheral nerve damage;Peripheral Nervous System;Peripheral Nervous System Diseases;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Platinum Compounds;Play;prevent;Preventive treatment;Process;processing speed;Proto-Oncogene Proteins c-jun;Quality of life;Rattus;Reporting;Rodent Model;Role;Sensory;side effect;Signal Pathway;Signal Transduction;Skin;Small Interfering RNA;small molecule inhibitor;SP600125;Spinal Ganglia;Symptoms;taxane;Testing;Therapeutic;Time;Toxic effect;Transgenic Organisms;translational potential;United States;Vinca Alkaloids;Woman

PROJECT_TITLE: Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Genetics;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative: The overarching goal of this study is to identify effective metabolic based diagnostic and therapeutic strategies to improve the overall survival of patients with Non-small cell lung cancer (NSCLC). We propose to investigate the positron emission tomography (PET) tracer, 18F-BnTP as a novel metabolic diagnostic and to develop metabolic based therapeutic strategies targeting oxidative mitochondrial metabolism in therapy resistant KRAS/LKB1 and EGFR mutant lung tumors. This work represents a new approach to overcoming therapy resistance in KRAS/LKB1 and EGFR mutant lung tumors – one in which the tumor’s metabolic and bioenergetic dependencies are profiled and then selectively targeted.

PI_NAMEs: SHACKELFORD, DAVID B (contact)

PROJECT_TERMS: 3-Dimensional;Address;advanced disease;American;Area;Biguanides;Bioenergetics;Biological Markers;Biopsy;Cancer Patient;cancer therapy;Cell Line;Cell Respiration;checkpoint therapy;Classification;Clinical;Complex;Data;Dependence;Diagnosis;Diagnostic;diagnostic strategy;Disease;Disease Resistance;Dissection;driver mutation;Electron Transport;Epidermal Growth Factor Receptor;Exhibits;fluorodeoxyglucose;Functional Imaging;Gene Expression Profiling;Genetically Engineered Mouse;Goals;Health;Human;image guided;imaging probe;Immuno-Chemotherapy;Immunotherapy;improved;in vivo;in vivo evaluation;in vivo imaging;inhibitor;Knowledge;KRAS2 gene;Lung Adenocarcinoma;Lung Neoplasms;Maintenance;Malignant neoplasm of lung;Measures;Membrane Potentials;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;Mitochondria;mitochondrial membrane;mitochondrial metabolism;mutant;Mutation;nano-string;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel diagnostics;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenic;Oxidative Phosphorylation;patient derived xenograft model;Patients;Phenotype;Phosphorylation Inhibition;Physiological;Positron-Emission Tomography;Rationalization;Research;Resistance;Resistance development;Site;Spirometry;stem;STK11 gene;Structure;superresolution microscopy;Survival Rate;targeted treatment;Testing;Therapeutic;therapy development;therapy resistant;Time;Tracer;treatment response;tumor;tumor initiation;tumor metabolism;Tyrosine Kinase Inhibitor;uptake;Work

PROJECT_TITLE: In vivo imaging of mitochondria structure and function in therapy resistant lung tumors

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PI_NAMEs: EISEN, JONATHAN A.;NEWSOME, SETH ;SHAPIRO, KAREN  (contact);VANWORMER, ELIZABETH

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Environmental forces shape the ecology of virulent parasites in coastal ecosystems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-U (55)]