NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Ocular inflammatory disease represents an important and disproportionate cause of visual morbidity, yet real- world data to inform appropriate health policy regarding disparities in its development, progression, treatment patterns, and economics are lacking. Indeed, the restricted scope of prior case series and population studies render the epidemiology of uveitis to be poorly understood, particularly for vulnerable populations in the healthcare safety net setting. This project seeks to leverage the strengths of two unique databases, a national medical claims database and electronic medical record data from our local healthcare safety net, which contain large and diverse cohorts of patients, to explore health disparities in the development, progression, and treatment of ocular inflammatory diseases – a foundational step in innovating targeted interventions to mitigate these disparities.

PI_NAMEs: TOY, BRIAN  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: access disparities;Address;Affect;Age;age group;age related;American;Area;barrier to care;Biological;Biostatistical Methods;Blindness;career development;Caring;Case Series;Cataract;Chronic Disease;Cicatrix;Classification;Clinical;clinical care;clinical database;Clinical Informatics;Clinical Research;Clinical Services;Code;cohort;comorbidity;Computerized Medical Record;cost;County;Data;Data Mart;Data Set;Databases;Development;Diagnosis;Disease;disease diagnosis;Disparity;disparity reduction;economic disparity;Economics;Education;Environment;Epidemiology;Ethnic Origin;experience;Formularies;Foundations;Future;Geography;Glaucoma;Goals;Grant;hazard;Health;Health Care Costs;health disparity;health economics;Health Policy;Health Services;Health Services Research;Health system;Healthcare;Healthcare Systems;high risk;immunomodulatory therapies;improved;Incidence;Income;indexing;Inflammation;Inflammatory;Informatics;innovation;insight;Insurance;interest;International Classification of Diseases;Intervention;Knowledge;Leadership;Logistics;Longitudinal Studies;Los Angeles;Low income;Low Income Population;low socioeconomic status;Manuscripts;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modeling;Morbidity - disease rate;multidisciplinary;novel;Patient Care;Patients;Pattern;Patterns of Care;Persons;Pharmaceutical Preparations;Pharmaceutical Services;population based;Population Heterogeneity;Population Intervention;Population Study;practice setting;Prevalence;programs;Race;racial disparity;Rare Diseases;Regression Analysis;Reporting;Research;Risk;Risk Factors;risk stratification;safety net;Sampling;Science;Scleritis;sex;skills;Smoking;Smoking Status;socioeconomic disparity;Socioeconomic Status;socioeconomics;standardized care;Steroids;Surgeon;Target Populations;Testing;Training;treatment comparison;treatment pattern;Treatment Protocols;United States;Uveitis;Validation;Vision;Visual;Vulnerable Populations;Writing

PROJECT_TITLE: Health Disparities in the Development, Persistence, and Progression of Uveitis and Ocular Inflammation in the United States


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Rural community health workers embedded in clinical survivorship care teams—CHW-clinical survivorship care teams—is a strategy to improve fragmented rural survivorship care, adherence to follow-up, and facilitate linkages to local resources to overcome socio-economic barriers to care. This project will examine the feasibility, acceptability, and implementation of a pilot telehealth CHW-clinical survivorship care team intervention focused on resource referrals and connections, symptom management between follow-up care visits, and improving adherence to post treatment follow-up care recommendations of lung cancer survivors from rural areas. This research will contribute to the lack of literature addressing the implementation of survivorship care models to improve rural survivorship outcomes and eliminate disparities in rural-urban survival rates.

PI_NAMEs: LEWIS, MARQUITA W. (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: acceptability and feasibility;Active Learning;Address;Adherence;Adopted;Advocate;Aftercare;barrier to care;cancer care;Cancer Center;Cancer Control;cancer health disparity;Cancer Survivor;Cancer Survivorship;cancer survivorship care;care coordination;career;Caregivers;Caring;Clinical;clinical care;Communities;Community Developments;community engagement;Community Health;Community Health Aides;Cost Analysis;Counseling;County;Data;Development;disparity elimination;Distal;Division of Cancer Control and Population Sciences;Early Diagnosis;early screening;Economics;effectiveness/implementation trial;Exploration, Preparation, Implementation, and Sustainment;Face;feasibility testing;Financial Hardship;Financial Support;follow-up;Future;Geography;Goals;Health;Health Care Costs;health disparity;Health Professional;implementation cost;implementation evaluation;implementation framework;implementation science;improved;improved outcome;Incidence;insight;Intervention;Interview;Light;Link;Literature;Malignant neoplasm of lung;Managed Care;medically underserved;member;Mentors;Mentorship;Methods;Modeling;Monitor;Oncologist;Outcome;outcome disparities;Participant;patient navigation;patient navigator;Patients;Phase;Preparation;Process;Program Development;programs;Provider;PrP gene;Recommendation;Recurrence;Research;Research Project Grants;Resources;Role;Rural;Rural Appalachia;rural area;Rural Community;rural dwellers;rurality;screening;side effect;Site;skills;social;social health determinants;Social Workers;socioeconomics;Specialist;success;Support Groups;survival disparity;Survival Rate;Survivors;survivorship;symptom management;telehealth;therapy development;Training;Travel;Treatment outcome;trial design;Trust;Universities;Urban Health;urban setting;Visit

PROJECT_TITLE: Improving adherence to posttreatment follow-up care for rural lung cancer survivors through a community-clinical survivorship care team model

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Wound Healing and Care

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Individual cells experience continuous assaults due to daily wear-and-tear, accidents, trauma, or infections and diseases that can lead to a ruptured cell cortex. Their survival depends on how efficiently and effectively they can repair such injuries. The focus of the proposed research is to investigate the regulatory mechanisms that facilitate proper cell wound repair in order to guide new therapies for treating damage and to identify key molecular players for informing regenerative medicine and/or improving clinical drug delivery approaches.

PI_NAMEs: PARKHURST, SUSAN M (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Accidents;Actins;Actomyosin;Address;assault;Biochemical;Biological;Biological Assay;Biological Process;cell cortex;cell injury;Cell membrane;Cell model;Cell Survival;Cells;Cessation of life;Clinical;clinically relevant;Complement;Complex;Cytokinesis;Cytoskeleton;daily functioning;Development;Discipline;Disease;Drosophila genus;Drug Delivery Systems;E-Cadherin;Embryo;Ensure;environmental stressor;Event;experience;experimental study;gene conservation;Gene Family;Genes;Genetic;genetic approach;Genetic Screening;Goals;healing;Homeostasis;Human;Image;imaging approach;improved;Individual;Infection;Infection prevention;Injury;injury and repair;insight;Integral Membrane Protein;interest;Ion Channel;Lesion;Malignant Neoplasms;Mammalian Cell;Medical;Membrane;model organism;Molecular;Nature;Neoplasm Metastasis;novel therapeutics;Nuclear Envelope;Organ;Organism;Pathway interactions;Pattern;physiologic stressor;Physiological;Play;Positioning Attribute;preservation;Process;Proteins;recruit;Regenerative Medicine;Regulation;repair model;repaired;Research;response;response to injury;Role;Rupture;seal;Speed;Structure;superresolution imaging;Time;Tissues;Trauma;Work;wound;wound closure;wound healing;Wound models

PROJECT_TITLE: Molecular and Cellular Mechanisms of Wound Repair

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: PEROJECT NARRATIVE The east and central Africa (ECA) region is a global hotspot for emerging infectious diseases (EID), associated with recurrent outbreaks of viral hemorrhagic fevers and detection of viruses emerging elsewhere that are capable of causing high morbidities and mortalities such as highly pathogenic influenza, Zika, and Middle East respiratory syndrome coronavirus (MERS-COV). We propose to establish an Emerging Infectious Disease Research Center (EIDRC), headquartered in Nairobi but with surveillance distributed throughout the region. The Center will conduct pilot research on maintenance and transmission of RVF virus and MERS-CoV; conduct systematic pathogen discovery and development of diagnostics and research reagents; and support response to outbreaks of suspected EID the region by conducting timely clinical and socio-cultural outbreak research that enhances characterization of outbreaks, leading to implementation of prevention and control measures.

PI_NAMEs: NJENGA, M KARIUKI (contact)

PROGRAM_OFFICER_NAME: WOODSON, SARA ELAINE

PROJECT_TERMS: Africa;Africa South of the Sahara;African;Agriculture;Air;Animals;arid land;Asia;Berlin;Birth;Camels;Centers for Disease Control and Prevention (U.S.);Central Africa;Cessation of life;China;Circulation;Clinical;Clinical Research;cohort;Collaborations;Communicable Diseases;Communities;community living;Congo;Coronavirus;Coronavirus Infections;Country;County;Democratic Republic of the Congo;density;Development;diagnostic development;Disease;Disease Outbreaks;Disease Surveillance;Dromedaries;Eastern Africa;Ebola;Emerging Communicable Diseases;emerging pathogen;emerging virus;Environment;Epidemic;Europe;experience;field study;follow-up;Food;forest;Frequencies;Genotype;global health;Health;health care availability;health seeking behavior;High Prevalence;Hospital Referrals;Human;human disease;improved;Incidence;Infant;Infection;Infectious Diseases Research;Influenza;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H5N1 Subtype;influenza epidemic;Infrastructure;International;Kenya;Knowledge;Laboratories;Life Style;Livestock;Longitudinal cohort study;Maintenance;Marburgvirus;marginalization;marginalized community;Measures;Middle East;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Morbidity - disease rate;mortality;Occupations;outbreak response;Outpatients;pathogen;Pathogenicity;Phenotype;physical conditioning;Physicians;Pilot Projects;Population;Predisposition;Prevention;programs;Public Health;Reagent;Recurrence;Regional Disease;Reporting;Research;respiratory;response;Rift Valley Fever;Rift Valley fever virus;Risk;Risk Assessment;Role;Sampling;Scientist;Seroprevalences;Services;Severe Acute Respiratory Syndrome;Severities;Severity of illness;Site;social culture;Tanzania;Telephone;Testing;translational study;transmission process;Travel;Tropical Medicine;Uganda;United States;Universities;vector;Veterinarians;Viral;viral detection;Viral Hemorrhagic Fevers;viral outbreak;Viral reservoir;viral transmission;Virulence;Virulent;Virus;Virus Diseases;Virus Shedding;Visit;Washington;World Health Organization;ZIKA;Zoonoses

PROJECT_TITLE: Emerging Infectious Diseases Research Center - East and Central Africa


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE: Emergency general surgery (EGS) is associated with the highest risk, acuity, complication rates, and cost in general surgery - particularly the subset of emergency laparotomy patients, which suffer the worst EGS outcomes - and is increasingly recognized as a surgical public health crisis. Despite a number of major postoperative complications occurring commonly after discharge (notably over 40% of surgical site infections), recovery for surgical patients once discharged to home remains understudied and ripe for improvement and innovation including use of novel digital solutions. Using systems engineering approaches, REST-PSLL (Re-engineering Surgical Recovery and Transitions Using Technology Patient Safety Learning Laboratory) has the end goal of enabling safe surgical recovery at home for emergency laparotomy patients.

PI_NAMEs: MARQUARD, JENNA LOUISE;MELTON-MEAUX, GENEVIEVE B (contact);WICK, ELIZABETH C

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: REST-PSLL: Re-engineering Surgical Recovery and Transitions Using Technology Patient Safety Learning Laboratory

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: The goal of my research is to develop and test healthcare delivery models in the VA health care system to improve the delivery of quality, efficient, and patient-centered care. I have led > 30 federally funded (HSR&D, QUERI) and foundation projects. I am collaborating with the Offices of Rural Health (ORH) and Connected Care. Additionally, I am the PI/Co-PI of 3 IIRs, 2 ORH funded projects, and 2 industry-funded projects occurring in the VA. I am the PI of a U01 and a K12 training grant both from NHLBI. Since 2013, I published >160 papers. More than half of these were coauthored with VA mentees. I am the primary mentor for 2 CDAs, secondary mentor on 6 other CDA/K awards. Proposed activities include: 1) develop methods for scaling and adapting interventions for veterans with comorbid conditions, 2) facilitate the evaluation of models of virtual care as they pertain to the Mission Act legislation, and 3) mentorship. The Senior RCS award will allow me to enhance my contributions to the VA HSR&D mission and improve care for Veterans with chronic conditions.

PI_NAMEs: BOSWORTH, HAYDEN B (contact)

PROJECT_TERMS: Achievement;Address;Adherence;Adoption;Aging;American Heart Association;Area;Award;Behavior;Books;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;care coordination;career;Caring;Chronic;Chronic Care;Chronic Disease;Circulation;Clinical;Clinical Trials;Collaborations;Communication;comorbidity;complex chronic conditions;Computerized Medical Record;connected care;Counseling;Dedications;Deimplementation;Development;disparity elimination;Doctor of Philosophy;Educational Curriculum;Educational process of instructing;Effectiveness;Effectiveness of Interventions;effectiveness trial;Enrollment;Ensure;Evaluation;Faculty;Focus Groups;Foundations;Funding;Goals;Grant;Guidelines;health care delivery;health care disparity;health care quality;Health Information National Trends Survey;Health Sciences;Health Services;Health Services Accessibility;Health Services Research;Health system;Healthcare Systems;Heterogeneity;HIV;Home;Homogeneously Staining Region;Hypertension;hypertension control;implementation science;Improve Access;improved;indexing;Individual;Industry;interest;International;Intervention;Intervention Studies;Investigator-Initiated Research;K-Series Research Career Programs;Knowledge;Lead;Leadership;Low Literacy Population;Medicaid;Medication Management;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Meta-Analysis;Methodology;Methods;Mission;Modeling;Monitor;National Heart, Lung, and Blood Institute;North Carolina;nursing intervention;operation;Outcome;Paper;Patient Education;patient response;Patient-Centered Care;Patients;Peer Review;personalized medicine;Pharmacists;Population;population health;post intervention;Postdoctoral Fellow;pragmatic trial;Preventive care;Primary Care;Principal Investigator;Program Appropriateness;programs;Provider;Publications;Publishing;Qualitative Methods;Quality of Care;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;research study;research to practice;Resources;response;Risk;Risk Management;Risk Reduction;Role;Rural;Rural Health;rural healthcare;rural setting;Scholars Program;Scientist;Self Management;self-management program;Service delivery model;Services;Statutes and Laws;Stroke;Study Section;System;Technology;Telemedicine;telephone based;Testing;Time;Training;Translating;treatment as usual;treatment effect;treatment response;United Kingdom;United States National Institutes of Health;Update;uptake;Veterans;virtual assessment;virtual healthcare;virtual model;Work;working group

PROJECT_TITLE: HSR&D Senior Research Career Scientist Award

STUDY_SECTION_NAME: HSR-7 Capacity Building[HSR7]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Up to 80% of high grade serous ovarian cancer (HGSC) patients succumb to their disease due to both lack of early detection and limited therapeutic options. Genomic analysis of these tumors has suggested that up to 50% may have difficulty in repairing damage to their DNA which might make them therapeutically sensitive to a variety of available drugs; and functional analyses of HGSC tumor cells has revealed that many tumor cells are defective in repairing specific damage generated when the cells duplicate their DNA. The work in this proposal will help to better understand how HGSC tumor cells with defects in repairing this type of damage interact with the surrounding normal cells, and how these interactions lead to sensitivity and resistance to certain therapies.

PI_NAMEs: HILL, SARAH JAMES (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Adjuvant Chemotherapy;Advisory Committees;Aftercare;B-Lymphocytes;Biological Models;Blood Vessels;Cancer Biology;Cancer Patient;Carboplatin;career;Cell Communication;Cells;Clinical;clinical training;Coculture Techniques;combat;Combined Modality Therapy;Complement;crosslink;cytokine;cytotoxicity;Dana-Farber Cancer Institute;Defect;Dendritic Cells;Development;Disease;DNA;DNA Repair;DNA replication fork;DNA Sequence Alteration;Early Diagnosis;Environment;Epithelium;Equipment and Supplies;Evolution;experience;Financial Support;Flow Cytometry;gene repair;Generations;Genetic Fingerprintings;Genetic Transcription;Genomics;Goals;Growth;Growth Factor;human tissue;Immune;In Vitro;innovation;insight;Institution;Knowledge;Lead;Leadership;Macrophage;Malignant neoplasm of ovary;Medical Oncology;Mesenchymal;Molecular;multidisciplinary;Natural Killer Cells;Neoadjuvant Therapy;neoplastic cell;neutrophil;Normal Cell;novel;Organoids;Pathway interactions;Patients;Pharmaceutical Preparations;Platinum;prevent;professor;programs;Publications;Publishing;repaired;Research;Research Personnel;Research Training;Residencies;Resistance;response;Selection for Treatments;Serous;single-cell RNA sequencing;skills;Stress;Stromal Cells;System;Systemic Therapy;T-Lymphocyte;targeted treatment;Technology;Therapeutic;therapy resistant;Time;Tissue Sample;Training;treatment response;tumor;tumor microenvironment;Tumor-infiltrating immune cells;Vision;Work

PROJECT_TITLE: Dissecting the interaction between DNA damage repair defects and the tumor microenvironment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: STATE COLLEGE OF OPTOMETRY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Myopia (nearsightedness) is a leading cause of vision impairment. It is a growing public health concern because its prevalence is increasing significantly, which increases the prevalence of several vision-threatening conditions associated with myopia and more vision loss. This project examines gene expression in the eye to identify the cellular and molecular mechanisms controlling eye growth and the development of myopia. The results will provide important insights about the causes and control of myopia in children and form the basis for new and effective treatments to reduce myopia and vision loss.

PI_NAMEs: BENAVENTE-PEREZ, ALEXANDRA  (contact);ROSKA, BOTOND

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Age;Agonist;Animal Model;antagonist;Biochemical;Biochemical Pathway;Bioinformatics;Biological;Biology;Blindness;Callithrix;Candidate Disease Gene;Cell model;cell type;Cells;cellular targeting;Child;Choroid;Clinical Research;comparison group;Complex;Complication;Contact Lenses;Data Set;Development;disorder of macula of retina;effective therapy;emmetropization;epigenome;epigenomics;Evidence based treatment;experience;experimental study;Extracellular Matrix;Eye;Eye Development;Fibroblasts;functional genomics;Future;gene environment interaction;Gene Expression;gene regulatory network;Genes;genome sequencing;genome wide association study;Genomics;Glaucoma;Grant;Growth;Growth and Development function;Human;Hyperopia;Immunohistochemistry;In Situ Hybridization;insight;International;Investigation;knockout gene;large datasets;lens induction;Mass Spectrum Analysis;Methodology;Methods;MicroRNAs;Modeling;Molecular;Molecular Analysis;Molecular Target;mouse model;Myopia;new technology;new therapeutic target;nonhuman primate;novel therapeutics;Optics;Output;Pathway interactions;Perception;Peripheral;Pharmaceutical Preparations;Population;postnatal;Prevalence;primate development;Probability;Process;Proteins;Proteome;Proteomics;Public Health;Refractive Errors;Regulatory Pathway;Research;Research Personnel;Resolution;Resource Sharing;response;Retina;Retinal Detachment;Risk;Sclera;Signal Pathway;Signal Transduction;single cell technology;Techniques;Technology Assessment;Testing;Tissue-Specific Gene Expression;Tissues;transcriptome;transcriptomics;Translations;Treatment Efficacy;Validation;validation studies;Vision;Visual;Visual impairment

PROJECT_TITLE: Molecular Mechanisms of Emmetropization and Experimental Myopia at Single Cell Resolution

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Wound Healing and Care

ORG_CITY: WASHINGTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative (max. 2-3 sentences)  The nerves on the corneal surface play roles in dry eye disease and diabetes. Their dysfunction can cause  chronic pain and contribute to photophobia and migraines and their loss leads to corneal inflammation and  keratitis. The experiments proposed will improve our understanding of how corneal sensory nerves are  maintained and how they regenerate after injury.

PI_NAMEs: STEPP, MARY ANN  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: afferent nerve;Apical;Axon;Blindness;Cell Physiology;Cells;central nervous system injury;chronic pain;circadian regulation;Cornea;corneal epithelium;Corneal Injury;Cytoplasm;Darkness;Data;Debridement;Dendritic Cells;density;Diabetes Mellitus;diabetic;Dry Eye Syndromes;Epithelial Cells;Epithelium;experience;experimental study;Exposure to;Functional disorder;Funding;Goals;Growth;Herpesviridae Infections;Homeostasis;Impairment;improved;In Vitro;in vivo;Inflammation;Injury;injury recovery;intraepithelial;Irritants;Keratitis;Knowledge;Lead;Light;Lysosomes;Mammals;Mediating;Metabolic;Migraine;Mitochondria;Mitomycin C;Molecular;Mus;Natural regeneration;Nerve;Neuroglia;neuron loss;Neuroprotective Agents;Neurotrophic Keratitis;ocular surface;ocular surface disease;Pathology;Phagocytosis;Phase;Photophobia;Play;preservation;prevent;Recurrence;reinnervation;Research;response;response to injury;Rest;Resting Phase;Role;Secondary to;Signal Transduction;Stress;Stroke;Structure of retinal pigment epithelium;Structure of trigeminal ganglion;Surface;Testing;Therapeutic;Time;Tissues;Topical application;Trauma;Virus Diseases;Vision;Work;wound healing

PROJECT_TITLE: Molecular mechanisms of corneal recurrent erosion formation

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Hematology;Human Genome;Precision Medicine;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Mutations to DNA acquired during the lifetime of an organism may accumulate and result in a tendency for the groups of cells, or clones, that harbor them to grow faster and thus expand. Such clones, including those with alterations to their chromosomes such as deletions or duplications of DNA, are detected in the blood of >5% of older individuals and cause increased mortality through increased risk of cardiovascular disease, infection, cancer, kidney disease and lung disease. We will use genomics and computational approaches to estimate the rates at which these clones are expanding in 1.3 million individuals to understand the molecular causes and consequences of expanding clones on aging health and disease.

PI_NAMEs: AUER, PAUL L.;BICK, ALEXANDER  (contact);SCHEET, PAUL A

PROGRAM_OFFICER_NAME: RAGHAVACHARI, NALINI

PROJECT_TERMS: Address;Affect;Age;Aging;aging mechanism;aging related disease;Area;biobank;Biological;Blood;Blood Cells;blood fractionation;Blood specimen;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cell Lineage;Cell Proliferation;cell type;Cells;Chromosome abnormality;Chromosomes;Chronic Disease;Chronic Lymphocytic Leukemia;clinical phenotype;Clonal Expansion;Clonal Hematopoietic Stem Cell;cohort;Collection;Computing Methodologies;Data;Development;differential expression;Disease;Disease Outcome;disorder risk;DNA;DNA Sequence Alteration;Environmental Risk Factor;Epidemiology;Gene Expression;Gene Expression Profile;Genes;Genetic;Genome;Genomic approach;genomic data;Genomics;Health;healthy aging;Hematology;Hematopoiesis;Hematopoietic stem cells;high risk;Human;Immune;improved;Individual;individualized prevention;Infection;Inflammation;Inflammatory;insight;Integration Host Factors;Intervention;Kidney Diseases;Knowledge;Lead;Learning;life span;Loss of Heterozygosity;Lung Diseases;Lymphoid;Malignant Neoplasms;Maps;Measures;Mediating;Methods;Modeling;Molecular;molecular modeling;mortality;mosaic;Mosaicism;Multi-Ethnic Study of Atherosclerosis;multidisciplinary;Mutate;Mutation;Myelogenous;National Heart, Lung, and Blood Institute;novel;Older Population;Organism;Pathway interactions;Pattern;phenome;Phenotype;Pneumonia;Point Mutation;Population;population health;Predictive Factor;Predisposing Factor;Process;programs;prospective;Research Activity;Risk;Risk Factors;Sampling;screening;single-cell RNA sequencing;Site;Somatic Mutation;statistics;stem cell differentiation;success;Surveys;targeted treatment;therapeutic development;Time;Tissues;Trans-Omics for Precision Medicine;transcriptome sequencing;United States National Institutes of Health;whole genome;Women's Health;Work

PROJECT_TITLE: Establishing the dynamics of lymphoid clonal hematopoiesis and its aging-related disease consequences

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: The proposed work is relevant to public health because the discovery of molecular mechanisms of Rhes- SUMO mediated cell-type specific role and interneuronal transport of cargo in animal models is ultimately expected to increase understanding of mechanisms of Rhes-SUMO signaling in neurological disorders, as well as provide framework for developing novel therapeutic strategies, based on novel mechanisms-based approaches. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to acquiring basic insights that will aid to lessen the pain of human of disability.

PI_NAMEs: SUBRAMANIAM, SRINI  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Actins;Address;Affect;Aging;Anatomy;Animal Diseases;Animal Model;Animals;Area;Atrophic;Autophagocytosis;Behavior;Behavioral;Binding;Brain;Brain Diseases;Brain region;cell type;Cells;Corpus striatum structure;Cultured Cells;Data;disability;Disease;disease model;Disease Progression;Distant;DRD2 gene;drug discovery;Energy Metabolism;Etiology;expression vector;farnesylation;Genetic Diseases;Genetic Transcription;Glutamine;Homologous Gene;Human;Huntington Disease;Huntington gene;In Vitro;in vivo;Inflammation;inhibition of autophagy;inhibitor;insight;Interneurons;Knock-in Mouse;Knowledge;Link;live cell imaging;Mass Spectrum Analysis;Mediating;Membrane;Mission;Modification;Molecular;Mus;mutant;Nanotubes;Nervous System Disorder;Neuroglia;Neurons;neuropathology;new therapeutic target;novel;novel therapeutic intervention;Onset of illness;Oxidative Stress;Pain;Pathogenesis;Pathway interactions;Peripheral;pharmacologic;Phenotype;polyglutamine;Post-Translational Protein Processing;prevent;Process;Proteins;Public Health;ras Proteins;Reporter;Research;Role;Route;Signal Transduction;Slice;Specificity;SUMO1 gene;Sumoylation Pathway;Synapses;Testing;Tissues;Toxic effect;Transgenic Animals;transmission process;Transportation;Ubiquitin;United States National Institutes of Health;Viral Vector;white matter;Work

PROJECT_TITLE: Rhes-SUMO Pathway in Huntington disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: DAVIS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE The mission of our collaborative Bridges to the Baccalaureate program is to help diversify the pool of biomedical research scientists in the United States. Our program partners with American River College (ARC), a local community college, to support students as they transfer from ARC to UC Davis, a four-year baccalaureate degree granting institution and finish their degrees in normative time. We accomplish these goals by providing authentic research training experiences at both ARC and UC Davis that build our trainees’ sense of belonging in biomedical research, understanding of ethical and moral responsibilities, and rigorous technical skills required for their academic and professional success.

PI_NAMEs: ELLEFSON CROWDER, MARINA LYN;FACCIOTTI, MARC TANCREDI (contact);TOPINKA, JOHN

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Academic skills;American;Bachelor's Degree;Biological Sciences;Biology;Biomedical Engineering;biomedical scientist;bridge program;bridge to the baccalaureate;career development;CCL7 gene;Collaborations;college;Communities;community college;Data Analyses;Elements;Environment;Exclusion;experience;Experimental Designs;Exposure to;Faculty;faculty mentor;faculty research;Generations;interest;Low income;Mentorship;Mission;outreach;Population;Professional Competence;programs;recruit;Reproducibility;Research;Research Support;Science;Students;success;Time;Training;Training Programs;transfer student;undergraduate research;undergraduate research experience;undergraduate student;United States National Institutes of Health;university student;Woman

PROJECT_TITLE: Bridges to the Baccalaureate

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE An expansive array of inherited retinal diseases emanate from one general etiology: mutations in Peripherin 2 (PRPH2); however, clinical manifestation of PRPH2-diseases can vary, even amongst those with the same mutation. We propose to explore the role of Rom1 in modulating Prph2-disease phenotypes by assessing the outcomes of Rom1 modulation in clinically recapitulative animal models of Prph2-associated disease. Identification of common mechanisms of Rom1 modification between differing Prph2 diseases can move the field towards exploring broader methods of treatment for this wide spectrum of diseases.

PI_NAMEs: IKELLE, LARISSA  (contact)

PROJECT_TERMS: Address;Affect;Affinity Chromatography;Animal Model;Attention;Backcrossings;Behavior;Binding;Biochemical;Bypass;cell type;Clinical;Co-Immunoprecipitations;Complex;conditional knockout;Cone;Data;Development;Disease;disease heterogeneity;disease model;disease phenotype;effective therapy;Electron Microscopy;Etiology;Exhibits;Future;Goals;Golgi Apparatus;Health;Homo;Homologous Gene;Imaging Techniques;Impairment;In Vitro;in vivo;in vivo Model;Inherited;innovation;interest;Investigation;Knock-out;Knowledge;Leucine Zippers;Macular degeneration;macular dystrophy;Maintenance;Membrane Microdomains;Membrane Proteins;Methods;microscopic imaging;Modeling;Modification;Molecular Conformation;Morphogenesis;mutant;Mutation;Nature;Neural Retina;Outcome Assessment;Outcome Study;overexpression;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Pattern;pattern dystrophies;peripherin;Phenotype;photoreceptor degeneration;Photoreceptors;Process;Proteins;Psammomys;Rattus;Research;Resolution;Retina;Retinal Diseases;Retinitis Pigmentosa;Rod;Rod Outer Segments;Rodent Model;Role;Sand Rats;Severity of illness;Silicon Dioxide;Structure;syntaxin;Testing;Therapeutic;therapeutically effective;Three-dimensional analysis;trafficking;Vertebrate Photoreceptors

PROJECT_TITLE: The differential behavior of Prph2/Rom1 in rods and cone contributes to Prph2-associated disease heterogeneity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: RICHMOND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Astrocytes, the most abundant glial cells in the central nervous system, perform a multitude of evolutionary conserved functions including, metabolic support to neurons, regulating blood-brain barrier, and modulating synapse-formation, -function and -plasticity, and are crucial in maintaining normal brain homeostasis. Dynamic crosstalk between astrocytes and neuronal synapses modulates most if not all of these functions, yet the molecular mechanism of neuron-astrocyte cross-communication at the synapse is largely untapped. Based on our preliminary studies, we propose a novel mechanism of neuron-astrocyte crosstalk at the synapse via S1P/S1PR1 signaling that regulates astrocyte function and neuronal synapse formation, function and plasticity.

PI_NAMEs: SINGH, SANDEEP KUMAR (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Astrocytes;Blood - brain barrier anatomy;Brain;Brain Diseases;Brain Pathology;Calcium;Central Nervous System;Communication;Coupled;Data;Development;Drug Targeting;Excitatory Synapse;Glutamates;Glypican;Goals;GTP-Binding Proteins;hevin;Homeostasis;In Vitro;in vivo;insight;Knock-out;Knowledge;Link;Mediating;Metabolic;Molecular;Morphogenesis;Morphology;Mus;Nervous System Disorder;neural circuit;Neuroglia;neuronal circuitry;neuronal growth;neuronal survival;Neurons;neuropathology;neurotransmission;novel;Process;Protein Secretion;Proteins;Publishing;receptor;Research;Role;Shapes;Signal Pathway;Signal Transduction;Sphingolipids;sphingosine 1-phosphate;sphingosine kinase;Sphingosine-1-Phosphate Receptor;Structure;Synapses;synaptic function;synaptogenesis;Testing;thrombospondin 4;Thrombospondins;vesicular glutamate transporter 2

PROJECT_TITLE: S1P-S1PR1 in bidirectional Neuron-Astrocyte communications

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: ITHACA

ORG_NAME: SCIENCENTER

PHR: PROJECT NARRATIVE BioBuilding: A traveling exhibit for future biomedical engineers Sciencenter The Sciencenter will develop a traveling exhibition on biomedical engineering for small to mid- sized museums across the nation, bringing together graduate students and faculty from Cornell University’s Meinig School of Biomedical Engineering and experts in exhibit development and reaching rural audiences from the Sciencenter and the University of Montana spectrUM Discovery Area to develop hands-on learning experiences that improve public understanding and appreciation for biomedical engineering and its impact on public health. BioBuilding will engage non-expert audiences through a hands-on exhibition and supporting interactive activities that highlight ongoing research and applications from biomedical engineering that are improving human health. This project will increase knowledge and interest in biomedical engineering amongst rural youth 6-12, with a longer-term goal of encouraging career development in this and related STEM fields by supporting a more comprehensive, diverse pipeline.

PI_NAMEs: TESTA, ADRIENNE  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Address;Affect;Age;Area;Awareness;Behavioral Research;bilingualism;Biomedical Engineering;Biomedical Research;career;career development;Clinical Research;Communication;Communities;Creativeness;design;Development;Diagnosis;Disease;effectiveness evaluation;Evaluation;evidence base;exhibitions;Exhibits;experience;Faculty;Family;field trip;Fostering;Future;General Population;Goals;graduate student;Growth;Hand functions;hands-on learning;Health;health equity;Health Sciences;Healthcare;Home;Human;improved;innovation;inquiry-based learning;interest;Journals;Knowledge;Learning;Medicine;Methods;Modeling;Montana;Museums;next generation;Outcome;outreach;Peer Review;Persons;posters;Process;programs;prototype;Public Health;Quality of life;Research;Research Design;Research Methodology;Resources;Rural;Rural Community;Schools;Science;science education;Scientist;skills;Spanish/English;square foot;Standardization;STEM field;symposium;teacher;Training;Travel;United States National Institutes of Health;Universities;Youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: Aurora

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proposed research is relevant to NEI mission because it studies fundamental circuit mechanisms that are involved in visual perception. Our work will provide novel theoretical and empirical approaches to understand neuronal function in and beyond the retina.

PI_NAMEs: POLEG-POLSKY, ALON  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Amacrine Cells;Animals;animation;Architecture;Behavioral;Biophysics;Brain;Calcium;Cell Communication;Cell Physiology;cell type;Cells;Characteristics;Complex;computer studies;Data;design;Electrophysiology (science);Elements;expectation;experimental study;extracellular;feature detection;Glutamates;Goals;Image;improved;innovation;insight;Interneurons;Linear Models;Machine Learning;machine learning model;Maps;Masks;Methodology;Mission;Modeling;Motion;Mus;Nature;neural circuit;Neurons;novel;novel strategies;object motion;Organism;Output;Outsourcing;Population;Positioning Attribute;Primates;Procedures;Process;receptive field;Research;response;Rest;Retina;Retinal Ganglion Cells;Shapes;Signal Transduction;simulation;Site;spatiotemporal;Speed;Stimulus;Stream;Surveys;Techniques;Technology;Testing;theories;Time;Translating;Visual;visual information;Visual Perception;visual processing;Work

PROJECT_TITLE: Novel experimental and machine learning - assisted techniques to assess receptive field functionality in the retina

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE We have identified a series of novel compounds that reduce the production of Low Density Lipoprotein Cholesterol (LDL-C) from the liver, and we reason that the compounds act as irreversible inhibitors of carboxylesterase 1 in hepatocytes. They represent a new class of compounds that could potentially be used to treat homozygous familial hypercholesterolemia (hoFH), steatosis, and as a complement to statins to help the general population meet cholesterol goals. We propose to determine the compound’s mechanism of action and whether they are effective in humanized mouse models.

PI_NAMEs: DUNCAN, STEPHEN A (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Affinity;Alleles;antagonist;Binding;Binding Proteins;Biochemical;Biological Assay;candidate identification;Carboxylesterase 1;Cardiovascular Diseases;Cessation of life;Characteristics;Chemical Structure;Cholesterol;Collection;Complement;Coronary Arteriosclerosis;Crystallography;Data;drug discovery;efficacy evaluation;Enzyme Inhibition;Enzymes;Equilibrium;esterase;Evaluation;Familial Hypercholesterolemia;Family;Fatty Liver;Formulation;General Population;Goals;Healthcare;Hepatic;Hepatocyte;High Density Lipoproteins;high resolution imaging;Human;human induced pluripotent stem cells;humanized mouse;hypercholesterolemia;induced pluripotent stem cell;inhibitor;Investigational New Drug Application;LDL Cholesterol Lipoproteins;Lead;Left;Libraries;Lipids;Liver;liver injury;loss of function mutation;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Mass Spectrum Analysis;Measures;Mediating;Metabolism;Molecular;mouse model;Mus;Mutation;novel;Oxidoreductase;particle;Patients;Pharmaceutical Preparations;Physiology;preclinical development;prevent;Production;Property;Proteins;Resistance;Risk;Role;Safety;Series;Serum;side effect;small molecule;South Carolina;Specificity;Structure-Activity Relationship;success;Sulfhydryl Compounds;Triazines;Triglycerides;Variant;Very low density lipoprotein;Very low density lipoprotein cholesterol;X-Ray Crystallography

PROJECT_TITLE: Inhibition of hepatic (V)LDL production by a novel antagonist of carboxyl esterase 1

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Kidney Disease;Organ Transplantation;Social Determinants of Health;Transplantation

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative A crisis in the United States is that nearly 100,000 individuals are on the list for a kidney transplant and almost half die or become too sick while waiting because of a profound shortage of kidneys. Millions of healthy Americans are potentially willing and able to donate a kidney, but due to knowledge and communication barriers, the tremendous potential of live donation to meet the need for kidneys remains unrealized. To address the problem, we developed a novel educational and communication solution for transplant candidates to increase their access to live donor kidney transplantation that, once tested, will be disseminated nationwide.

PI_NAMEs: FEELEY, THOMAS ;KAYLER, LIISE  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Address;American;animation;Attitude;Behavior;Cessation of life;Cognition;Cognitive;Communication;Communication Barriers;community collaboration;Community of Practice;Consensus;Data;design;Devices;Dialysis procedure;dosage;E-learning;Education;Education and Outreach;Educational Intervention;Effectiveness;effectiveness testing;Electronic Mail;End stage renal failure;Ensure;Evaluation;evidence base;experience;Exposure to;Family;flexibility;follow-up;Friends;Funding;Future;Goals;Health;health communication;implementation strategy;improved;Individual;innovation;interest;Intervention;intervention effect;intervention refinement;Intervention Studies;Kidney;Kidney Diseases;Kidney Transplantation;Knowledge;Learning;Length;Link;Living Donors;living kidney donor;Measures;member;Metadata;Mission;Modeling;Morbidity - disease rate;mortality;Multicenter Trials;multidisciplinary;Multimedia;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Online Systems;optimal treatments;Organ Donations;Outcome;outreach;Participant;patient oriented;Patient Self-Report;Patients;Persons;Pilot Projects;post intervention;premature;Process;process evaluation;Quality of life;Randomized, Controlled Trials;Readiness;Recommendation;recruit;Reporting;Research;Research Personnel;research study;Risk;Self Assessment;Self Efficacy;social media;Social Network;Social support;Societies;Stream;success;Surveys;symposium;Technology;Testing;Text;therapy development;tool;transplant centers;Transplant Surgeon;Transplantation;treatment as usual;United States;uptake;web site

PROJECT_TITLE: Increasing Live Donor Kidney Transplantation Through Video-based Education and Mobile Communication

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Lung;Networking and Information Technology R&D (NITRD);Pediatric;Telehealth

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE This project will help address one of the leading causes of mortality in young children worldwide, acute lower respiratory illnesses (ALRI), through a mobile health decision support tool called ALRITE. ALRITE is designed as a point-of-care decision support tool to aid health workers in diagnosing and treating young children with ALRI in Uganda. The proposed study is a critical step towards the ultimate goal of improving outcomes for pediatric ALRI in resource-constrained settings.

PI_NAMEs: ELLINGTON, LAURA E (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Active Learning;Acute;Address;Adherence;Adoption;Africa South of the Sahara;aged;Antibiotics;Asthma;Breathing;Bronchiolitis;Bronchodilator Agents;care delivery;career development;Case Management;Categories;Cessation of life;Chest;Child;Childhood;Chronic Disease;clinical care;clinical decision support;Clinical effectiveness;Collaborations;college;Community Health Aides;Complex;Consolidated Framework for Implementation Research;cost;Coughing;Data;design;Development Plans;Diagnosis;Disease;Education;Effectiveness;Environment;Epidemiology;Evaluation;evidence base;experience;Feasibility Studies;Focus Groups;global health;Goals;Grant;Guideline Adherence;Guidelines;Health;Impact evaluation;implementation determinants;implementation facilitation;implementation outcomes;implementation research;implementation science;implementation strategy;improved;improved outcome;Information Sciences;Infrastructure;Integrated Health Care Systems;International;Interruption;Intervention;Interview;Leadership;Life;low and middle-income countries;Lung;Maps;Master of Science;Measures;medical schools;Mentored Clinical Scientist Development Program;Mentorship;Methods;mHealth;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Outcome;Outcome Assessment;Outcome Measure;participant retention;pediatric health outcomes;Penetration;Physicians;pilot test;Pneumonia;point of care;Pragmatic clinical trial;pragmatic trial;preference;Prevention strategy;primary outcome;Process;prototype;Public Health;Public Health Schools;Quasi-experiment;Recommendation;Research;Research Activity;Research Personnel;Resource-limited setting;Resources;respiratory;Running;Series;skills;smartphone application;support tools;Surveys;Symptoms;Systems Integration;Testing;Time;tool;Training;Training Activity;treatment strategy;Triage;trial design;Uganda;Universities;usability;Washington;Wheezing;World Health Organization

PROJECT_TITLE: Evaluating a mobile health tool to improve management of pediatric acute respiratory illness in Uganda

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: This application proposes to study the role of nonsense mediated decay in nonsense mutation biology and the pharmacologic correction of nonsense mutations. This proposal uses the human genetic disorder Cystic Fibrosis as a model; however, approximately 10% of all genetic diseases are caused by nonsense mutations which historically have been difficult to treat. This work will increase the understanding of nonsense mutation heterogeneity and may lead to the development of precision medicine approaches to treat nonsense mutations thereby significantly reducing disease burden worldwide.

PI_NAMEs: MICHICICH, MARGARET  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Alleles;amlexanox;Animal Model;Animals;antibiotic G 418;beta Thalassemia;Bioinformatics;Biological Assay;Biological Models;Biology;burden of illness;Caffeine;career;Cell Physiology;cell type;Cells;Clinical Research;Clinical Trials;Communication Research;Congenic Mice;Cystic Fibrosis;cystic fibrosis mouse;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Development;Disease;Drug Combinations;drug testing;Duchenne muscular dystrophy;efficacy testing;Embryo;Failure;Forskolin;Future;Genes;Genetic Diseases;Genotype;Heterogeneity;Heterozygote;Human;Human Genetics;human tissue;improved;In Vitro;in vitro Model;in vivo;in vivo evaluation;in vivo Model;Inbred CFTR Mice;inhibitor;Intestines;Location;Low Prevalence;Measures;Modeling;mouse model;Mus;Mutation;mutation correction;Nonsense Codon;Nonsense Mutation;Nonsense-Mediated Decay;novel;Organoids;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;pre-clinical;precision medicine;Predisposition;premature;prevent;Process;protein folding;protein function;Proteins;Resistance;resistance mutation;restoration;Role;Science;Severities;Severity of illness;Small Intestines;Swelling;Techniques;Terminator Codon;Testing;Therapeutic;Tissues;Toxic effect;Training;Transcript;Translating;Translational Research;Translations;Treatment Efficacy;treatment response;Work

PROJECT_TITLE: Investigating the role of NMD in Nonsense Mutation Biology and Therapeutic Strategies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE An emerging paradigm in cancer immunology states that the aberrant transcription of repeat RNA in cancer is a critical mechanism for engaging tumor intrinsic and extrinsic immune and regulatory factors, and an untapped source of potential therapeutic targets. Using a set of approaches from statistical physics, our team predicted repeat RNA stimulates receptors of the innate immune system, confirmed this hypothesis in a key subset of immune cells, and showed classes of repeat RNA can correlate with response to immunotherapies. Our goal is to identify the classes of structural and sequence features of repeat mediated immune activation in solid tumors and clarify their specific consequences for tumor evolution, the state of the immune microenvironment, and cancer immunotherapies.

PI_NAMEs: GREENBAUM, BENJAMIN  (contact);TING, DAVID TSAI

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Antigen-Presenting Cells;Antigens;Archives;Biological Assay;Cancer cell line;cancer immunotherapy;Cancer Patient;Cancerous;Cells;Clinical;cohort;Colon Carcinoma;Colorectal Cancer;cost;cytokine;Cytotoxic T-Lymphocytes;Dendritic Cells;design;Detection;Double-Stranded RNA;Epigenetic Process;Evolution;exosome;experience;Family;fitness;Genetic Transcription;Goals;Human;Immune;immune activation;immune checkpoint blockade;Immune response;Immune signaling;Immune system;Immunohistochemistry;Immunologic Markers;Immunologic Receptors;Immunologics;Immunotherapy;in silico;In Situ Hybridization;In Vitro;in vitro Assay;in vivo;Individual;Innate Immune Response;Innate Immune System;interdisciplinary approach;Length;Link;liquid biopsy;Machine Learning;Macrophage;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;mathematical model;Measures;Mediating;Methods;mimicry;Modeling;Molecular Biology;neoantigens;Normal tissue morphology;novel;novel marker;Oncornaviruses;Outcome;pathogen;Pathway interactions;patient subsets;Patients;Pattern;Phenotype;Physics;Plasma;Procedures;Production;Prognosis;Property;receptor;Recording of previous events;Repetitive Sequence;response;RNA;RNA analysis;Role;role model;Sampling;single molecule;Solid Neoplasm;Source;Spatial Distribution;Statistical Models;stem;Structure;System;Technology;therapeutic target;tool;Transcript;transcriptome sequencing;transcriptomics;Treatment Efficacy;treatment response;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;tumor-immune system interactions;uptake;Validation;Virus

PROJECT_TITLE: A Statistical Physics Framework for Understanding the Role of Repeat RNA in Tumor Immunity


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Nashville

ORG_DEPT: CHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: NARRATIVE Underrepresented minority (URM) scholars at predominately White institutions (PWIs) often contend with numerous challenges that impact their research success and productivity. There are empirically supported problems with recruiting and retaining URM faculty in academia and the biomedical workforce. The overarching goal of the Faculty Accomplished Community that Cultivates Equity and Success in Science (ACCESS) Program, is to provide URM early and mid-career faculty with tools and resources needed to be successful biomedical scientific leaders by centering wellness and resiliency.

PI_NAMEs: ROBINSON, RENA A. S. (contact);STEVENS-WATKINS, DANELLE J

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Academia;Affect;Applications Grants;Asian;Biomedical Research;black men;Black race;black women;burnout;career;career life balance;career networking;Climate;cohort;Collaborations;Color;Communication;Communities;coping;Coupled;design;Development;Development Plans;Ensure;Equity;experience;Faculty;faculty mentor;faculty research;fighting;follow-up;Funding;Goals;Grant;Hispanic;holistic approach;Home;Institution;Journals;K-Series Research Career Programs;Knowledge;Latino;marginalization;Measures;member;Mentors;mid-career faculty;Motivation;Needs Assessment;Outcome;Output;Participant;Pattern;people of color;Politics;Postdoctoral Fellow;Productivity;programs;Publications;Race;recruit;Reporting;Research;Research Project Grants;resilience;Resources;Science;Self Efficacy;senior faculty;Services;skill acquisition;skills;social;social capital;Social Network;Social support;Stress;stress reduction;Structural Racism;success;tenure track;tool;Training;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Well in self;Wellness Center;Writing

PROJECT_TITLE: Ensuring success in academia for underrepresented faculty to advance biomedical science research


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Columbus

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative A diverse workforce requires encouraging mentors, interesting projects and engaging opportunities. This summer experience will capitalize on experts in the field to grow undergraduate interest in biomedical informatics and data science and encourage engagement in professional experiences that solve complex public health problems. The dual-mentorship experience, with a clinical or operational expert and a methods or quantitative expert will give the students a well-rounded and unique experience fostering collaborative science and giving them a competitive edge for graduate applications.

PI_NAMEs: HEBERT, COURTNEY L. (contact);ZHANG, PING

PROJECT_TERMS: Address;Artificial Intelligence;Bioinformatics;biomedical informatics;Biometry;career;career development;Clinical;Clinics and Hospitals;Collaborations;college;Complex;computerized tools;Country;Creativeness;Critical Thinking;Data Collection;Data Science;Dedications;design;Disparity;Diverse Workforce;Doctor's Degree;Education;Educational Curriculum;Educational workshop;Electronic Mail;Environment;evidence base;experience;Exposure to;Faculty;Feedback;Fostering;Future;Goals;Graduate Education;graduate school;Graduation Rates;Grant;Health Sciences;implementation science;Individual;Informatics;innovation;insight;Institution;interdisciplinary collaboration;Interdisciplinary Education;interest;Internships;Journals;Knowledge;Laboratory Research;learning outcome;Medical center;Medicine;member;Mentors;Mentorship;Methods;Monitor;Ohio;online tutorial;Outcome;peer;population health;Positioning Attribute;Productivity;programs;Public Health;Published Comment;Research;research faculty;Research Project Grants;Resources;Science;skill acquisition;Structure;student participation;Students;summer internship;summer program;summer research;Surveys;Technical Expertise;Testing;Thinking;Training;Training and Education;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Work

PROJECT_TITLE: OSU Summer Internship Program in Biomedical Informatics and Data Science


ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: PROJECT NARRATIVE This award will enable the development and testing of a new computational tool for non-invasively predicting the risk of rupture of abdominal aortic aneurysms based on estimating their rupture potential index. This research is expected to challenge the current guidelines for clinical management of the disease, as well as the presurgical planning capabilities of vascular and endovascular aneurysm repair.

PI_NAMEs: FINOL, ENDER A (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Abdomen;abdominal aorta;Abdominal Aortic Aneurysm;abdominal CT;abdominal pressure;Aneurysm;Award;Biomechanics;Blood Vessels;Clinic;Clinical;Clinical Management;Clinical Research;clinical translation;comorbidity;Computer software;computerized tools;Consent;Death Rate;Detection;Development;Diameter;Disease;Disease Management;Elasticity;Event;Exhibits;Finite Element Analysis;follow-up;Future;Geometry;Goals;Growth;Guidelines;Human Subject Research;Image;indexing;Individual;Knowledge;Life;Measurement;Measures;Mechanical Stress;Mechanics;Membrane;Methods;Modeling;Operative Surgical Procedures;Outcomes Research;Patient observation;Patients;Periodicals;Physics;prevent;Probability;Procedures;Property;prospective;Protocols documentation;Recommendation;repaired;Research;research study;Residual state;Risk;Risk Assessment;risk prediction;Rupture;Ruptured Abdominal Aortic Aneurysm;Shapes;standard of care;Stress;Surveillance Program;Technology;Testing;theories;Thick;Thrombus;Tissues;ultrasound;X-Ray Computed Tomography

PROJECT_TITLE: A NONLINEAR MEMBRANE BASED ANALYSIS FOR ESTIMATING THE RUPTURE POTENTIAL OF ABDOMINAL AORTIC ANEURYSMS

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Infectious Diseases;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: WOODINVILLE

ORG_NAME: BANFIELDBIO INC.

PHR: Project Narrative Within the US, ticks transmit 18 human pathogens, the most injurious being the bacteria that cause Lyme disease, for which there are an estimated 476,000 cases per year. There is a critical need for improvement in tick management products as the incidence of tick-borne diseases is rising with the changing climate and current tick-repellent and/or acaricidal products employ a pyrethroid chemical to which ticks are increasingly resistant. We aim to formulate polymeric microparticles designed to carry non-volatile acaricides into granules and fibers capable of controlled release of volatile repellents and/or toxicants; granules would be used in landscape applications to remove and repel ticks, and fibers would be incorporated into the fabric used to make outerwear garments that protect humans from acquiring and being bitten by ticks.

PI_NAMEs: BANFIELD, MICHAEL GILBERT (contact);CRAWLEY, SYDNEY ;JOINER, JILLIAN ;REISKIND, MICHAEL HAY;WEST, ANDRE ;WILLIAMS, SCOTT C.

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: acaricide;Adult;Ambylomma americanum;Area;Award;Bacteria;Behavior;Biological Assay;Bite;Black-legged Tick;Characteristics;Chemicals;climate change;Clothing;commercialization;controlled release;Cytoplasmic Granules;Data;design;Detection;Development;Dose;efficacy evaluation;Ensure;Evaluation;experimental study;Fiber;Filament;Formulation;Geographic Locations;global temperature;Goals;Habitats;Human;human disease;human pathogen;improved;Incidence;Insecticides;Invaded;Journals;Laboratories;laboratory experiment;Legal patent;Longevity;Lyme Disease;manufacture;manufacturing scale-up;manufacturing technology;meetings;Methods;Mus;novel;Outcome;Paper;Participant;particle;Pathway interactions;Peer Review;Permethrin;Persons;Pest Control;Phase;Poison;Polymers;Porosity;preference;prevent;Preventive treatment;Procedures;Production;prototype;Publications;Publishing;pyrethroid;research and development;Resistance;Resistance development;Route;scale up;Site;Solvents;Statistical Data Interpretation;Technology Transfer;Testing;Textiles;tick bite;Tick Control;tick transmission;Tick-Borne Diseases;Ticks;Toxic effect;toxicant;vector;Volatilization;Walking;Work;Writing

PROJECT_TITLE: Polymeric matrix loaded with tick repellent or toxic compositions for incorporation into fabrics or for granular dispersal

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-C(12)]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: SHEFFIELD

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: CERTARA UK LIMITED

ORG_ZIPCODE: S1 2BJ

PHR: Project Narrative Virtual bioequivalence (VBE) uses mechanistic physiologically-based pharmacokinetic models to simulate realistic virtual cohorts of patients which can replace full clinical trials. However, well-defined workflows and examples of VBE applications are lacking; this study will develop an integrated VBE platform yielding optimal decisions for a matter directly related to the health and safety of patients, and their optimal treatment. Our software platform will help generic drug development and regulatory reviews, but also innovators’ drug development, enhancing drug efficacy, availability and safety for all the world’s population.

PI_NAMEs: BOIS, FREDERIC  (contact);CRISTOFOLETTI, RODRIGO

PROGRAM_OFFICER_NAME: ALAM, KHONDOKER

PROJECT_TITLE: A State-of-the-Art Virtual Bioequivalence Platform and Case Studies on Complex Formulations, Systemic and Local Concentration-based Bioequivalence


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: ABUJA

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: UNIVERSITY OF ABUJA

PHR: PUBLIC HEALTH RELEVANCE  Nearly half of Nigerian adults have hypertension, and Nigeria has announced a national sodium reduction program for population-level hypertension prevention and control based on the WHO’s best buy SHAKE package. Using a type 3 hybrid study design and the EPIS, CFIR, and RE-AIM frameworks, we will perform a baseline health needs assessment (UG3 phase) and follow-up assessments (UH3 phase) using stakeholder interviews, population surveys, and retail surveys. This embedded study will optimize local, regional, and national implementation and will provide generalizable knowledge about implementation strategies to lower dietary sodium intake at scale.

PI_NAMEs: HUFFMAN, MARK D;OJJI, DIKE BEVIS (contact)

PROGRAM_OFFICER_NAME: BRUNO, FERNANDO PEREIRA

PROJECT_TERMS: Address;Adopted;Adoption;Adult;Advocacy;Age;China;Chronic;Collaborations;Communities;Consumption;contextual factors;cost;Cross-Sectional Studies;crowdsourcing;Data;Data Collection;Developing Countries;dietary;Dietary Assessment;Dietary Sodium;Disease;Effectiveness;effectiveness measure;empowerment;Environment;evidence based guidelines;Excretory function;Exploration, Preparation, Implementation, and Sustainment;Failure;follow up assessment;follow-up;Food;Food Supply;Funding;global health;Health;Healthy Eating;Hour;Hybrids;Hypertension;hypertension control;hypertension prevention;implementation barriers;implementation cost;implementation evaluation;implementation measures;implementation outcomes;implementation research;implementation strategy;Industry;insight;Intake;International;International Agencies;Intervention;Interview;Knowledge;knowledge translation;Label;Laws;Maintenance;Marketing;Mass Media;Measurement;Measures;meetings;member;Methods;Modeling;multidisciplinary;National Heart, Lung, and Blood Institute;Nature;Needs Assessment;Nigeria;Nigerian;novel;Outcome;Phase;Policies;Policy Maker;Policy Making;Population;Population Programs;population survey;Preparation;Prevention;Process;Proctor framework;Program Development;programs;public health relevance;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Design;Research Methodology;Research Training;Resource-limited setting;Restaurants;rural area;rurality;salt intake;scale up;sex;Sodium;Source;Strategic vision;Surveys;System;tool;Training;Training Programs;United States Food and Drug Administration;Universities;urban area;urinary

PROJECT_TITLE: Evaluating the Implementation and Scale-Up of Nigeria National Sodium Reduction Program


ADMINISTERING_IC: AR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH This UCLA/UCSD Acne Center of Research Translation (CORT) is composed of a multidisciplinary team involving basic scientists and physician scientists engaged in translational research. Working together, leveraging innovative technologies and institution resources, the proposed research will lead to advances in understanding how the relationship of the skin microbiome in acne and healthy skin, as well as lipid metabolism, with the host immune response contributes to the pathogenesis of acne and skin homeostasis. The outcomes of this research will provide insight into strategies to alter the interaction of the microbiome, lipid metabolism and the immune response in order to change the course of acne and other inflammatory skin diseases.

PI_NAMEs: GALLO, RICHARD L;MODLIN, ROBERT L (contact)

PROGRAM_OFFICER_NAME: GREEN PARKER, MELISSA C

PROJECT_TERMS: Acne;Address;adipokines;Architecture;Bacteria;base;Bioinformatics;Biological;Biopsy Specimen;cathelicidin;cell type;Cells;Center for Translational Science Activities;Clinical and Translational Science Awards;Communities;Core Facility;Cutaneous;Data;data integration;Dermal;Dermatology;design;Development;Disease;disease model;Environment;Faculty;Feasibility Studies;Fibroblasts;Fostering;Generations;Genes;genetic signature;Goals;graduate student;Homeostasis;Human;Immune response;Immunology;In Vitro;Inflammation;Inflammatory;innovation;innovative technologies;insight;Institution;Intervention;Lesion;Link;lipid metabolism;lipidomics;Lipids;Macrophage;Maps;Medical Students;meetings;member;Mentors;Metagenomics;Microbe;microbial;microbial genomics;Microbiology;microbiome;microbiota;Modeling;Molecular;multidisciplinary;Mus;network models;novel therapeutic intervention;Outcomes Research;Pathogenesis;Patients;Physicians;Pilot Projects;Population;Postdoctoral Fellow;Production;programs;Proliferating;Public Health;Reactive Oxygen Species;Research;Research Personnel;Research Project Grants;Research Support;Resources;response;Role;Scientist;Sebum;Shapes;single-cell RNA sequencing;Site;Skin;skin disorder;skin microbiome;Squalene;stem cells;Testing;Time;transcriptomics;Translational Research;TREM2 gene

PROJECT_TITLE: Acne: a disease of lipid metabolism, microbiome and the immune response


NIH_SPENDING_CATS: Clinical Research;Microbiome

PI_NAMEs: MODLIN, ROBERT L (contact)

PROJECT_TERMS: Acne;Advisory Committees;Advocacy;American;Area;Budgets;Center for Translational Science Activities;Clinical Investigator;Collaborations;Communication;Communications Media;Communities;Dermatology;Disease;Ensure;Evaluation Research;Financial Support;flexibility;Fostering;Goals;Human Resources;Immune response;Immunology;Individual;Infrastructure;inter-institutional;Leadership;lipid metabolism;meetings;Microbiology;microbiome;Office of Administrative Management;operation;outreach;Patients;Productivity;programs;recruit;Reporting;Research;research and development;Research Personnel;Resources;Rosacea;Running;Schedule;Scientist;Site;Skin;skin disorder;skin microbiome;Societies;Structure;synergism;Translational Research;translational scientist;Underrepresented Populations;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Data Science;Genetics;Human Genome;Microbiome

PI_NAMEs: PELLEGRINI, MATTEO  (contact)

PROJECT_TERMS: Acne;Bioinformatics;Biology;Biopsy;cell type;Cells;Complex Mixtures;Data;Data Analyses;data analysis pipeline;data integration;Data Set;data tools;data visualization;Dedications;Disease;disease model;experience;Familiarity;Generations;Genes;Genetic;genomic data;genomic profiling;Genomics;Human;Immune;Immune response;Individual;Inflammatory;innovation;Lead;lipid metabolism;lipidome;lipidomics;Measures;member;Methodology;microbiome;Modality;Modeling;multiple data types;novel therapeutics;Process;programs;repository;Research;Research Personnel;Sampling;Services;Skin;skin biopsy;Techniques;Technology;tool;transcriptome;transcriptome sequencing;transcriptomics;two-dimensional;web site

PROJECT_TITLE: Bioinformatics Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: SEATTLE

ORG_DEPT: NEUROSURGERY

PHR: Narrative: Worldwide, traumatic brain injury (TBI) is a leading cause of death and disability among children and adolescents. We aim to test whether pediatric TBI treatment guided by invasive intracranial pressure monitoring produces better patient outcomes than care guided by a protocol without invasive monitoring. Study findings will inform clinical practice in treating pediatric severe TBI globally. Focused didactic and experience-based learning opportunities will increase the research capacity of pediatric intensivists in Latin America.

PI_NAMEs: CHESNUT, RANDALL M (contact);LUJAN, SILVIA B;MOYA-BARQUIN, LUIS ;PRIDGEON, JAMES STEPHEN;SULZBACHER, STEVEN I.;TEMKIN, NANCY R;VIDETTA, WALTER

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: 13 year old;acute care;Address;Adolescent;Adult;age related;Algorithms;Argentine;biomedical referral center;Brain;Brain Injuries;care outcomes;Caring;Cause of Death;Child;Childhood;clinical examination;clinical practice;Collaborations;Consensus;cost;Data;Databases;Developing Countries;Development;disability;Disease;efficacy testing;Electronics;Environment;Epidemic;Equipment and supply inventories;experience;Future;global health;Goals;Guatemala;Guidelines;HIV/AIDS;Human Resources;Image;Impairment;improved;improved outcome;Incidence;Infrastructure;Injury;injury burden;Intensive Care;Intracranial Pressure;Investigation;Journals;Latin America;Latin American;Learning;Length of Stay;Literature;low and middle-income countries;Malignant Breast Neoplasm;Measures;Monitor;mortality;Neurological outcome;New England;non-invasive imaging;Observational Study;Outcome;Outcome Measure;Patient Care;Patient-Focused Outcomes;Pattern;pediatric trauma;pediatric traumatic brain injury;Phase;Policies;Population;post-trauma;Prevention Measures;programs;Protocols documentation;Publishing;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Recovery;Recovery of Function;Research;Research Ethics;Research Personnel;Resources;Risk;Site;Societies;Spinal cord injury;Subgroup;targeted treatment;TBI Patients;TBI treatment;Testing;Thinking;Training;trauma care;trauma centers;Traumatic Brain Injury;treatment guidelines;Treatment Protocols;trend;trial comparing;Ventricular;Violence;Work

PROJECT_TITLE: Pediatric Severe Traumatic Brain Injury in Latin America – A Randomized Trial Comparing Two Management Protocols


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Genetics;Infectious Diseases;Microbiome;Nutrition

PI_NAMEs: GALLO, RICHARD L (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acne;Adult;Antibiotic Resistance;Antimicrobial Resistance;Atopic Dermatitis;Awareness;Bacteria;Behavior;Bioinformatics;Biological;Cells;Center for Translational Science Activities;Childhood;Clinical;Clinical Research;Collaborations;Complex;cost effective;Coupled;Data;Data Analyses;data integration;Data Set;data standards;Disease;DNA;Education;Elements;Equipment and supply inventories;Event;experience;Fermentation;Fibroblasts;Functional disorder;gene function;Generations;Genes;genetic information;Genome;Genomics;Goals;Growth;Human;Immune response;in vivo;insight;keratinocyte;large datasets;Libraries;lipid metabolism;lipidome;lipidomics;meetings;member;Metabolic;metabolome;metabolomics;metagenome;Metagenomics;Methodology;Microbe;microbial;Microbial Biofilms;microbial community;Microbial Genetics;Microbiology;microbiome;microbiome research;Modeling;multiple omics;Mus;Netherton syndrome;next generation;next generation sequencing;Organism;pathogen;Patients;Phenotype;Procedures;Process;Production;Protocols documentation;Psoriasis;Publishing;quorum sensing;Resistance profile;Resolution;Resources;Ribosomal RNA;Rosacea;Sampling;screening;sequencing platform;Shotguns;Site;Skin;skin microbiome;skin microbiota;Software Tools;Standardization;Swab;synergism;Taxonomy;Techniques;Technology;Testing;Toxin;Training;Training and Infrastructure;transcriptome;transcriptomics;Validation;Work

PROJECT_TITLE: Microbiology and Metagenomics Core


PROJECT_TERMS: Acne;Address;Animal Model;antimicrobial;Architecture;Bacteria;Binding;Bioinformatics;Biological;Biological Factors;Biopsy Specimen;cathelicidin;Cell Communication;cell type;Cells;Characteristics;Chronic;Complex;Cutaneous;cytokine;Data;Development;disability;Disease;Drug resistance;Elements;Fibroblasts;Functional disorder;Genes;Genomics;Goals;Host Defense;Human;Immune;immune activation;Immune response;Impairment;In Vitro;Inflammation;Inflammatory;Inflammatory Response;insight;Intervention;keratinocyte;Knowledge;Lesion;Link;lipid metabolism;lipidome;lipidomics;Lipids;Macrophage;Maps;Mass Spectrum Analysis;Mediating;Medical Care Costs;Mesenchymal Stem Cells;Metagenomics;microbial;Microbiology;microbiome;Modeling;Molecular;molecular marker;network models;novel therapeutic intervention;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pattern;Population;Process;Production;programs;psychologic;Reactive Oxygen Species;Research Personnel;Research Project Grants;Research Project Summaries;response;Role;Sampling;Sebum;Shapes;side effect;Signal Transduction;single-cell RNA sequencing;Site;Skin;skin disorder;skin microbiome;Squalene;Techniques;Testing;Time;TLR2 gene;transcriptomics;treatment strategy;TREM2 gene


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Tissue-based gene expression classifiers (GECs) are being increasingly utilized for men with localized prostate cancer to enhance the discriminatory power of standard clinicopathologic models and improve patient risk stratification. However, there remains a lack of evidence to support the widespread implementation of any of the GECs in clinical practice, with no prospective data demonstrating clinical utility or clinical impact of GEC testing on patient outcomes such as tumor control and quality of life. This work will produce a method to compare and implement risk thresholds across multiple GECs simultaneously, test the clinical utility and clinical impact of GEC testing in a new randomized trial of men with favorable risk prostate cancer, and perform long-term follow-up of the first ever randomized trial of GEC testing after radical prostatectomy (G- MINOR trial) to comprehensively determine the clinical impact of GEC use in localized prostate cancer.

PI_NAMEs: MORGAN, TODD M. (contact);SPRATT, DANIEL EIDELBERG

PROGRAM_OFFICER_NAME: GRIMES, GENEVIEVE M

PROJECT_TERMS: Address;Biochemical;Biopsy;Brain Neoplasms;cancer care;Cancer Control;Cancer Etiology;Cancer Patient;Categories;Classification;Clinical;clinical decision-making;clinical practice;clinical risk;clinically relevant;cohort;Conduct Clinical Trials;cost;Data;Decision Making;Development;Diagnosis;Discrimination;Disease;Eligibility Determination;Erectile dysfunction;Evaluation;expectation;Failure;follow-up;Future;Gene Expression;Genetic;Genomics;Goals;Grouping;Guidelines;Health Expenditures;Healthcare Systems;high risk;high risk men;improved;Incidence;Individual;Indolent;Longterm Follow-up;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Melanoma;men;Methods;Michigan;Modeling;Morbidity - disease rate;Nature;Newly Diagnosed;Outcome;overtreatment;Pathologic;Patient Care;Patient risk;Patient-Focused Outcomes;Patients;personalized medicine;Population;price lists;prospective;prostate cancer risk;Prostatectomy;Prostatic Neoplasms;Quality of life;Radiation Oncology;Radical Prostatectomy;Randomized;randomized trial;randomized, clinical trials;Recommendation;Recurrence;Recurrent disease;Registries;Reporting;Research;Risk;risk stratification;Shapes;Staging;Stratification;System;targeted treatment;Testing;Time;Tissues;Treatment Failure;Treatment-Related Cancer;tumor;Tumor Biology;tumor progression;ultrasound;uptake;Urinary Incontinence;Urologic Surgical Procedures;Urology;Walking;Work;years lived with disability

PROJECT_TITLE: Determining the clinical impact of gene expression testing in localized prostate cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Data Science;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Lymphatic Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: MISSISSIPPI STATE

ORG_NAME: MISSISSIPPI STATE UNIVERSITY

ORG_STATE: MS

PHR: Project Narrative The extracapsular extension (ECE) of the tumor in the lymph nodes is a significantly high-risk feature in head and neck cancers, which usually require pathologic confirmation. Predicting ECE during preoperative evaluation becomes a piece of critical information for clinicians planning treatment to avoid neck dissection and potential late toxicity such as fibrosis and worse lymphedema. This proposal will develop and evaluate a novel robust machine learning approach to facilitate both 1) understanding of using robust machine learning for directly ECE diagnosis on CT scans without manually annotating the lymph node information, and 2) assisting interpretation of the CT images through deep learning for ECE identification to enable improved clinical diagnostic efficiency and accuracy.

PI_NAMEs: DUGGAR, WILLIAM NEIL;WANG, HAIFENG  (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Adopted;Affect;Algorithms;Ally;American Joint Committee on Cancer;Anatomy;Area;Artificial Intelligence;artificial intelligence algorithm;Bioinformatics;Biological Markers;Cancer Biology;cancer biomarkers;Cessation of life;chemoradiation;Clinic;Clinical;clinical diagnostics;clinical implementation;Clinical Markers;Clinical Pathology;Communication;comparative;Computational Science;Consumption;cost effective;craniofacial;Craniofacial Abnormalities;Data;Data Science;Data Set;deep learning;Dental;Detection;Development;Diagnosis;Diagnostic Neoplasm Staging;diagnostic tool;disease diagnosis;Disease Progression;Evaluation;explainable machine learning;Extracapsular;Extramural Activities;Fibrosis;Funding;Future;Goals;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;Health Care Costs;high risk;HPV analysis;HPV negative;HPV positive;Human Papillomavirus;Image;Image Analysis;image guided;improved;improved outcome;interest;Knowledge;large datasets;lymph nodes;Lymphedema;Machine Learning;machine learning algorithm;machine learning method;Magnetic Resonance Imaging;Malignant Neoplasms;Manuals;Medical Imaging;Mission;Modality;Modeling;multimodal fusion;National Institute of Dental and Craniofacial Research;Neck Dissection;novel;Operative Surgical Procedures;Oral;Organ;Outcome;Pathologic;Pathological Staging;Pathology;Patients;PET/CT scan;Positron-Emission Tomography;Postoperative Period;Precision cancer therapy;precision medicine;Precision therapeutics;prediction algorithm;Process;Prognosis;Prognostic Marker;programs;Publishing;Radiation therapy;Radiology Specialty;Research;Research Design;Research Project Grants;Role;Salivary;Security;Site;Staging;Staging System;success;survival outcome;targeted treatment;Techniques;Testing;The Cancer Imaging Archive;Time;tool;Toxic effect;Translational Research;treatment planning;Treatment-related toxicity;Trust;tumor;Validation;validation studies;Work;X-Ray Computed Tomography

PROJECT_TITLE: Optimization and Validation of a Cost-effective Image-Guided Automated Extracapsular Extension Detection Framework through Interpretable Machine Learning in Head and Neck Cancer

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Genetics;Microbiome

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: The host 16-hydroxylates progesterone as a means of Phase I metabolism to excrete progesterone from the body. Intravenous administration of 16-hydroxyprogesterone resulted in urinary excretion of 17alpha-prenanolone and 17apha-progesterone which indicates that this excretion product is significantly modified in the gut and reabsorbed. This is significant because the side-chain is inverted during this process, and likely affects physiological function particularly in colon physiology and reproductive health.

PI_NAMEs: RIDLON, JASON MICHAEL (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: absorption;Address;Adrenal Cortex Hormones;Affect;Amino Acid Sequence;Anaerobic Bacteria;Androgens;Androstenedione;Bacteria;bacterial metabolism;Base Sequence;bile acid metabolism;biobank;Biochemical;Bioinformatics;Biological Assay;Collection;Colon;Colon Carcinoma;Cytochrome P450;Data;dehydroxylation;Disease;Enzyme Inhibitor Drugs;Enzymes;Escherichia coli;Excretory function;Feces;Funding;Gene Cluster;gene discovery;Genes;Goals;gut bacteria;gut microbiome;Health;Homologous Gene;host-associated microbial communities;Human;Human Microbiome;Hydrocortisone;Hydroxylation;Hydroxyprogesterone;immune function;innovation;Intestines;intravenous administration;Ketones;Ketosteroids;Knowledge;Libraries;Malignant neoplasm of prostate;Maps;Metabolic Biotransformation;Metabolism;metabolomics;Metagenomics;Methodology;microbial;microbiome;Mission;Mixed Function Oxygenases;novel;Organism;Oxygen;Pathway interactions;Peripheral;Phase;Phylogenetic Analysis;Physiological;Physiology;prevent;Probiotics;Process;Progesterone;protein expression;protein folding;Protein Isoforms;Reaction;Reproductive Health;Reproductive Physiology;Research;Risk Factors;Role;screening;stereochemistry;steroid metabolism;Steroids;stool sample;synthetic biology;therapeutic target;Tissues;transcriptome sequencing;transcriptomics;Transketolase;translational approach;United States National Institutes of Health;urinary;Urinary tract;Urine

PROJECT_TITLE: Gut bacterial metabolism of the side-chain of corticosteroids

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Prevention

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE This Training Program is designed to prepare the next generation of researchers who will fill workforce needs in cancer behavioral and psychosocial research. Cancer remains a leading cause of death and a major source of disability in the United States and throughout the world. The goal of the Training Program is to ensure that a talented and well-trained group of PhD and MD researchers is available in the years ahead to meet research needs to understand behavioral and psychosocial determinants and sequelae of cancer, reduce cancer risk, increase early disease detection, and improve the lives of community members who have developed cancer.

PI_NAMEs: CELLA, DAVID  (contact);HITSMAN, BRIAN L;YANEZ, BETINA

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Behavioral;Cancer Control;cancer prevention;psychosocial;Research Training

PROJECT_TITLE: Behavioral and Psychosocial Research Training in Cancer Prevention and Control

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: The Center for Visual Science at the University of Rochester has a large and vibrant community of 41 scientists engaged in vision research. We seek to renew our NEI P30 Core funding that allows us to maintain a staff of 10 highly-skilled experts who are software, optical, mechanical, and electrical engineers, in addition to a histologist and a clinical imaging professional. These technical staff members meet the collective needs of CVS faculty in achieving their research goals of understanding normal vision, as well as diseases of the visual system and the therapies to treat them.

PI_NAMEs: MARCOS, SUSANA  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: adaptive optics;Animal Model;Behavior;Cellular biology;clinical imaging;Communities;Computer software;Core Grant;Custom;Data Analyses;data modeling;Disease;Electrical Engineering;Eligibility Determination;Ensure;Equity;Eye diseases;Faculty;Funding;Generations;Goals;Grant;Histology;Human;Image;in vivo imaging;Institution;instrumentation;Mechanics;member;Microscopy;Mission;Modeling;Monkeys;Mus;neuromechanism;novel;Optics;Oryctolagus cuniculus;Productivity;Research;Research Personnel;Research Support;Resolution;Resources;retinal imaging;Scientist;Services;skills;Source;Stimulus;Technical Expertise;Technology;Universities;Vision;Vision research;vision science;Visual System

PROJECT_TITLE: Core grant for vision research


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Data Science;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Injury - Accidents and Adverse Effects;Stroke;Telehealth;Traumatic Head and Spine Injury

PI_NAMEs: DEANGELIS, GREGORY C (contact)

PROJECT_TERMS: 3-Dimensional;Ballistics;behavior test;Behavioral;Blindness;Blood flow;Calcium;Cells;clinical application;Collaborations;Computer software;computerized data processing;Core Grant;Custom;data acquisition;Data Analyses;design;Development;Electrodes;Engineering;Environment;Evaluation;experience;experimental study;Eye;Eye Movements;Faculty;fluorescence lifetime imaging;Generations;Human;Image;imaging approach;imaging capabilities;imaging modality;Impairment;Industry Standard;instrument;large datasets;member;Methods;Motion;Movement;neural;novel;novel strategies;optogenetics;Pathway Analysis;Patient Education;Photons;remote monitoring;Reporter;Research;Research Project Grants;Research Support;Retina;Services;sight restoration;software development;Software Tools;stem cell therapy;Stimulus;Stroke;stroke patient;Technology;temporal measurement;Time;Training;Traumatic Brain Injury;virtual reality;vision development;Vision research;vision science;Visual;visual stimulus;Visualization

PROJECT_TITLE: Computing Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Vaccine Related

ORG_CITY: NEW YORK

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative  SARS-CoV-2 infection can cause severe lung damage and death, and there are no effective medications or vaccines to treat or prevent the disease. Despite the ongoing efforts to develop antibodies against the virus’ spike protein, scientists have focused very little effort on TMPRSS2 as an alternative target. The overarching goal of this proposal is to use human pluripotent stem cell (hPSC)-derived lung organoids and air-liquid interface cultures, in combination with a SARS-CoV-2 hamster model, to identify underlying mechanism(s) blocking viral entry and to test the efficacy of AL20 (a TMPRSS2 monoclonal antibody) and serine protease inhibitors (serpins, which are endogenous inhibitors of TMPRSS2) for preventing SARS-CoV-2 infection.

PI_NAMEs: CHEN, YA-WEN  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 2019-nCoV;3-Dimensional;ACE2;Age;Air;airway epithelium;alveolar type II cell;Animal Model;Antibodies;Apoptosis;Binding;Binding Proteins;Case Study;Cell Line;Cell surface;Cell Survival;cell type;Cells;Cessation of life;Clinical;Complex;COVID-19;COVID-19 impact;COVID-19 susceptibility;COVID-19 treatment;cytotoxicity;Data;Disease;Distal;DNA Sequence Alteration;dosage;drug candidate;efficacy evaluation;efficacy testing;Endocytosis Induction;Ensure;Environment;Epithelial Cells;Family;Goals;Hamsters;Human;Human Characteristics;human disease;human pluripotent stem cell;Immunologics;In Vitro;in vivo;Incubated;Individual;individual patient;Infection;infection rate;Inflammation;Influenza A virus;inhibiting antibody;inhibitor;insight;Lead;Learning;Liquid substance;Lung;lung injury;Mediating;Mesocricetus auratus;Modeling;Molecular;Monoclonal Antibodies;Mus;Mutate;neutralizing antibody;novel;novel therapeutic intervention;novel therapeutics;Organoids;pandemic disease;Passive Immunization;Pathogenesis;Patients;Peptide Hydrolases;Pharmaceutical Preparations;pluripotent stem cell differentiation;Population;prevent;Process;Production;Proteins;Pulmonary Pathology;receptor;Regulation;Resistance;respiratory;respiratory virus;response;RNA Viruses;Role;SARS coronavirus;SARS-CoV-2 entry inhibitor;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 spike protein;Scientist;Serine Proteinase Inhibitors;Serpins;stem cells;Structure;System;Testing;therapeutic candidate;Time;Tissues;TMPRSS2 gene;Transgenic Organisms;transmission process;trend;unvaccinated;vaccine hesitancy;vaccine-induced immunity;Vaccines;Variant;Viral;viral entry inhibitor;Virus;Virus Diseases;Work

PROJECT_TITLE: TMPRSS2 as a potential target for treatments of COVID-19 and respiratory infectious viruses in lung

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(05)]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: MACON

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MERCER UNIVERSITY MACON

ORG_STATE: GA

PHR: PROJECT NARRATIVE Autism spectrum disorder (ASD) frequently goes undetected in rural communities or is detected late, which can impair the ability of children with ASD to thrive both mentally and socially. Lack of awareness about ASD symptoms and resources among clinicians and community members in rural areas is a significant contributor to delayed diagnosis. Expanding our Autism Spectrum Resources in Georgia webpage into an online ASD ToolKit and developing an accompanying online course for Georgia healthcare workers will provide information and guidance on providing care for patients with ASD.

PI_NAMEs: ROTSCHAFER, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Address;Adult;Advertisements;Affect;Age;Area;Autism Diagnosis;autism spectrum disorder;autism symptoms;autistic children;Awareness;biomedical resource;Cellular Phone;Child;Child Care;Clinical Trials;Code;Collaborations;commune;Communities;continuing medical education;County;Databases;Dedications;Dentists;Diagnosis;Diagnostic;diagnostic criteria;Disease;Disparity;Early Intervention;Education;evidence base;executive function;experience;Failure;Family;Feedback;Focus Groups;Friends;Geography;Goals;Health;health care availability;Health Personnel;Health Resources;Home;Impairment;Income;Independent Living;Individual;individuals with autism spectrum disorder;Information Resources;innovation;insight;Intervention;Knowledge;Language;language impairment;Link;literacy;Literature;Maps;medical schools;Medical Students;medically underserved;MedlinePlus;meetings;member;Mission;neighborhood disadvantage;Newsletter;online course;Pamphlets;Parents;Patient Care;Patients;Physicians;prevent;Process;programs;Provider;Psyche structure;Reading;repetitive behavior;Research;Resources;Rural;rural area;Rural Community;rural counties;rural families;Rural Health;sensory processing disorder;service providers;Services;Severities;Shapes;Signs and Symptoms;sixth grade;social;social communication;Social support;socioeconomic disadvantage;Spanish;Support Groups;symptomatic improvement;Symptoms;telehealth;Testing;Therapeutic;Therapeutic Intervention;Thinking;Time;tool;Training;treatment center;underserved community;United States National Library of Medicine;Universities;Urban Community;usability;web page;web site;Writing

PROJECT_TITLE: Autism Spectrum Disorder in Rural Georgia: Education and Resources


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: MERIGAN, WILLIAM H (contact)

PROJECT_TERMS: adaptive optics;Anatomy;animal imaging;Animals;Anterior;Antibodies;Awareness;Behavior;clinical imaging;Communities;Core Grant;Cornea;design;Development;Electrophysiology (science);Equipment;experience;Faculty;fundus imaging;Future;Goals;Grant;Harvest;Histologic;Histology;Human;human imaging;Image;imaging facilities;imaging Segmentation;In Situ Hybridization;instrument;Lateral Geniculate Body;Macaca;Maintenance;Measures;member;Methods;Microscopic;Microscopy;Monkeys;Morphology;Mus;Myopia;Optical Coherence Tomography;optical imaging;Optics;optogenetics;Pericytes;Property;Psychophysics;receptive field;Research;Research Activity;response;Retina;Retinal Ganglion Cells;retinal imaging;Role;Specialist;Structure;Students;superior colliculus Corpora quadrigemina;System;Technology;Testing;tissue preparation;Tissues;Training;Tretinoin;Vision;Vision research;Visual System;Visualization

PROJECT_TITLE: IMAGING CORE