NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: Los Angeles

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: There is a pressing need for new therapeutic strategies that rescue multiple forms of ALS and FTD, particularly those with unknown genetic etiologies. The proposed study will validate a new therapeutic mechanism, the induction of secretory autophagy, that we found through high-throughput screening to be one of the most potent ways of rescuing the degeneration of neurons derived from patients with diverse forms of ALS. We anticipate that this study will establish PIKFYVE kinase suppression and the activation of secretory autophagy as critical therapeutic targets for ALS, FTD, and related neurodegenerative diseases.

PI_NAMEs: ICHIDA, JUSTIN KAWIKA (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Address;Aging;ALS patients;Alzheimer's Disease;Alzheimer's disease patient;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotides;Autophagocytosis;Autophagosome;C9ORF72;causal variant;Cell Reprogramming;Chemicals;Complex;Data;Dipeptides;Disease;Dose;Drosophila genus;efficacy evaluation;efficacy validation;exosome;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Gene Mutation;Genes;Genetic;Genetic Predisposition to Disease;high throughput screening;Human;In Vitro;in vivo;Individual;Induced Neurons;induced pluripotent stem cell;inhibitor;Lipids;Lysosomes;Mainstreaming;Mediating;misfolded protein;Modeling;motor neuron degeneration;Motor Neurons;mouse model;multicatalytic endopeptidase complex;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;neuronal survival;Neurons;new therapeutic target;novel therapeutic intervention;novel therapeutics;Pathway interactions;Patients;Phenotype;Phosphotransferases;presenilin-1;prevent;protein TDP-43;Proteins;proteostasis;Research;sporadic amyotrophic lateral sclerosis;superoxide dismutase 1;System;Technology;Therapeutic;therapeutic target;therapeutically effective;Thinking;trafficking;Treatment Efficacy;Ubiquitin;Vesicle

PROJECT_TITLE: Validating Secretory Autophagy as a Therapeutic Strategy for Diverse Forms of ALS and FTD

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE This project, entitled “Mechanism and Consequences of Reverse Transcription in HIV-1 Cores,” will determine the mechanism by which the viral capsid promotes HIV-1 reverse transcription and define the structural and biochemical changes in the HIV-1 core that occur during specific stages of reverse transcription. Collectively, the information obtained in this project will be useful in the development and mechanistic understanding of antiviral drugs targeting the viral capsid.

PI_NAMEs: AIKEN, CHRISTOPHER R (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Amino Acid Substitution;Anti-Retroviral Agents;Anti-viral Agents;Atomic Force Microscopy;Binding;Binding Sites;Biochemical;Biological Assay;Biological Metamorphosis;biophysical techniques;Capsid;Cells;cellular targeting;Clinical Trials;Complex;Computer Models;Creativeness;crosslink;crosslinking and immunoprecipitation sequencing;deep sequencing;Development;Disease;DNA biosynthesis;Drug Targeting;ds-DNA;Ensure;Enzymes;Exhibits;experimental study;Genetic Transcription;genomic RNA;Goals;Helper-Inducer T-Lymphocyte;High-Throughput Nucleotide Sequencing;HIV;HIV-1;immunodeficiency;Immunoprecipitation;improved;In Vitro;Infection;inhibitor;insight;Integrase;Length;Maps;Medicine;Modeling;Molecular;Molecular Virology;mutant;Mutation;Negative Staining;nucleic acid binding protein;Nucleic Acids;Nucleoproteins;Nucleotides;particle;Pattern;Penetration;Peptide Hydrolases;Perilla;Persons;Pharmaceutical Preparations;Phytic Acid;Productivity;Proteins;Public Health;Radiolabeled;Reaction;Research;Reverse Transcription;RNA Binding;RNA-Directed DNA Polymerase;Role;scaffold;Series;Structure;Study models;System;Technology;Testing;therapeutic target;therapy resistant;Transmission Electron Microscopy;uptake;Viral;viral DNA;Viral Genome;viral genomics;Viral Physiology;Viral Proteins;viral RNA;Virus Diseases;Work

PROJECT_TITLE: Mechanisms and Consequences of Reverse Transcription in HIV-1 Cores

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: COLLEGE STATION

ORG_DEPT: CHEMISTRY

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative  Oxidation reactions are a critical class of organic transformations that enable installation of the structural complexity and chemical functionality critical for the activity of molecular therapeutics. Electrocatalysis represents an attractive approach to oxidation chemistry that avoids the typical requirement for stoichiometric chemical oxidants, however, fundamental challenges in coupling electrochemistry with organic synthesis prevent widespread implementation of these methods. The objective of this proposal is to develop new chemical strategies to harness electrochemically generated hypervalent iodine intermediates to enable an array of oxidative substrate functionalization reactions relevant to the synthesis of complex structures, such as molecular therapeutics.

PI_NAMEs: POWERS, DAVID C (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Metal-Free Electrocatalysis for Fine-Chemical Synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MADISON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Although plasma membrane protrusion and invagination are fundamental processes in all mammalian cells, very little is known about how they may be linked during normal neuron development. Here we will study the function of a protein family that may integrate invagination and protrusion and in doing so regulate process formation and neuronal migration in the developing brain. This protein family has also been implicated in Huntington's disease and several forms of cancer, underscoring the importance of this research for human disease of neuronal and non-neuronal origin.

PI_NAMEs: DENT, ERIK W (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Actin-Binding Protein;Actins;Address;Affect;Axon;Binding;Brain;Cell membrane;Cell Physiology;cell type;Cells;Cerebral cortex;CRISPR/Cas technology;Curiosities;Cytoskeleton;Data;Dendrites;design;Destinations;Development;dimer;dosage;Electroporation;Endocytic Vesicle;Endocytosis;Endocytosis Induction;Event;experimental study;Family;Family member;Filopodia;human disease;Huntington Disease;Immunoprecipitation;in utero;in vivo;insight;internal control;knock-down;Label;Link;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;Membrane;Microfilaments;Microtubules;migration;Molecular;Morphology;Mus;Nerve Degeneration;nervous system development;Nervous System Physiology;Neurites;neuron development;neuronal replacement;Neurons;novel;novel strategies;overexpression;Pattern;Peripheral;Play;polymerization;Polymers;Positioning Attribute;Process;Protein Family;protein function;Proteins;Publishing;Reagent;Reporter;Research;rho GTP-Binding Proteins;RNA Splicing;Role;Set protein;Signal Pathway;Structure;Techniques;Testing;TRIP10 gene;Variant;Vesicle;Work

PROJECT_TITLE: F-BAR proteins in neuronal migration and process formation


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cachexia;Emerging Infectious Diseases;Infectious Diseases;Lung;Microbiome;Nutrition;Orphan Drug;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: BERKELEY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE This proposal will identify the role of the microbiome in susceptibility to the human pathogen Mycobacterium tuberculosis. We will leverage genetically identical mice with diverse microbiomes and differing susceptibility to M. tuberculosis to pinpoint microbial and host factors contributing to infection burden and disease severity.

PI_NAMEs: WOLF, ASHLEY ROBIN (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Acceleration;active method;Area;Body Weight decreased;Cachexia;Cancer Model;Clinical;Clostridium difficile;commensal microbes;Communicable Diseases;Complex;COVID-19;Data;Dietary Factors;Disease;disease heterogeneity;Distal;Environmental Risk Factor;experience;fecal transplantation;follow-up;Future;Genetic;Genome;Germ-Free;Gnotobiotic;gut bacteria;gut microbiome;gut microbiota;Heterogeneity;House mice;Housing;Human;Human Genetics;human pathogen;Immune;immune function;Immune response;Immune system;immune system function;Immunocompromised Host;Immunologic Stimulation;improved;in vitro Assay;Individual;Infection;infection burden;Infection Control;Integration Host Factors;interest;Klebsiella;Laboratories;Life;Link;Lung;Malnutrition;Measures;Mediating;Metabolic;Metabolism;metabolomics;microbial;microbial community;microbial composition;microbiome;microbiome composition;microbiome research;microbiota;microbiota composition;Modeling;mouse model;Mus;Mycobacterium tuberculosis;new therapeutic target;novel;novel therapeutics;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Patients;personalized medicine;Persons;Phenotype;Physiological;Play;Predisposition;Prevention;Prophylactic treatment;Reproducibility;Research;response;Role;Route;Salmonella;Severities;Severity of illness;Shapes;Site;Source;stool sample;Symptoms;therapeutic target;Time;Transplantation;Tuberculosis;Variant;Vibrio cholerae;wasting;Work

PROJECT_TITLE: The role of the gut microbiome in susceptibility to Mycobacterium tuberculosis

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative This proposed research is expected to lay the foundation for advances in disease diagnosis, treatment, and personalized care through the integration and interpretation of cross-sectional and longitudinal data from multiple sources; it will contribute valuable tools and methods with potential for identiﬁcation of novel molecular targets for therapeutic interventions and for discovery of novel disease subtypes for improved patient prognosis.

PI_NAMEs: SAFO, SANDRA E (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Affect;Biological Markers;Biological Process;Charge;Clinical;Clinical Data;cohort;Complex;Data;Data Set;Disease;disease diagnosis;disorder subtype;Environmental Risk Factor;Epidemiology;Foundations;Genes;Genetic;Genomics;Heterogeneity;improved;insight;Lateral;machine learning algorithm;machine learning method;Medicine;metabolomics;Methods;Modeling;Molecular;molecular targeted therapies;multiple data sources;novel;Organ;Pathogenesis;Pathway Analysis;patient prognosis;patient subsets;personalized care;Production;Prognosis;Research;Source;statistical and machine learning;Systems Biology;Technology;theories;Therapeutic;Therapeutic Intervention;therapeutic target;Time;tool;Work

PROJECT_TITLE: Statistical and Machine Learning Methods to Address Biomedical Challenges for Integrating Multi-view Data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Microbiome;Sexually Transmitted Infections;Urologic Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE Chlamydia trachomatis is a common sexually transmitted bacteria, but we don’t understand why only some men who exposed to it get chlamydia and then spread this disease. We propose to study the microbiology and immunology of this pathogen in men to gain insights that will help us improve chlamydia management and prevention.

PI_NAMEs: JORDAN, STEPHEN J.;NELSON, DAVID EMMET (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;aged;Antibiotics;Antibodies;Antibody-mediated protection;Automobile Driving;Bacteria;Behavioral;Biological;Biological Assay;Blood;care seeking;Centers for Disease Control and Prevention (U.S.);cervicovaginal microbiome;Characteristics;Chlamydia;Chlamydia trachomatis;Clinical;comorbidity;Cross-Sectional Studies;diaries;Disease;Enrollment;Enzyme-Linked Immunosorbent Assay;Epidemic;Epidemiology;experience;Exposure to;Female;Heterosexuals;High Risk Woman;Immune;Immune response;Immune system;Immunity;Immunologics;Immunology;improved;Incubated;Infection;infection risk;Inflammation;insight;Knowledge;Longitudinal Studies;male;Measures;Mediating;men;metagenomic sequencing;Microbiology;microbiome composition;microorganism;Microscopy;Natural History;novel strategies;Nucleic Acid Amplification Tests;Organism;Outcome;Participant;pathogen;Patient Self-Report;Persons;Play;Predisposition;prevent;Prevention;Prospective Studies;Recommendation;Recording of previous events;reproductive tract;Resistance;Risk;Role;routine screening;screening;screening program;seropositive;sex;Sex Behavior;Sexual Partners;Sexual Transmission;Sexually Transmitted Diseases;Shapes;Signs and Symptoms;Slide;Specimen;Surveys;Symptoms;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Time;transmission process;Urethra;urethral microbiome;Urethritis;Urine;Visit;Woman

PROJECT_TITLE: The natural history of C. trachomatis urethral infections in men who have sex with women


ADMINISTERING_IC: HL

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  The Northwestern HeartShare Data Translation Center will provide overall management and oversight of the HeartShare program via 4 cores, including Administrative/Outreach, Data Portal, Data Management, and Cohort Cores. By providing a diverse investigative team and complementary areas of expertise, the HeartShare Data Translation Center will achieve the primary goals of HeartShare: (1) to develop a rich resource for the research community for the detailed study of heart failure; and (2) to advance the science of identifying novel heart failure subtypes to promote a tailored, precision medicine approach to heart failure patients in order to reduce morbidity and mortality.

PI_NAMEs: KHO, ABEL N.;LUO, YUAN ;SCHOLTENS, DENISE M;SHAH, SANJIV J (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Acceleration;Address;adjudication;advanced analytics;Ancillary Study;Area;biobank;Bioinformatics;Biological Specimen Banks;Biometry;Blood Vessels;Cardiac;Cardiovascular system;catalyst;Clinical;clinical center;Clinical Informatics;Clinical Research;cohort;Cohort Studies;Collaborations;Collection;Committee Members;Communication;Communities;computer human interaction;cost;Data;Data Aggregation;Data Coordinating Center;data integration;data management;data portal;data quality;Data Science;Data Scientist;Data Set;Disparate;Doctor of Philosophy;effective therapy;EFRAC;EHR research;electronic consent;Electronic Health Record;Ensure;Epidemiology;experience;Follow-Up Studies;Goals;health data;Heart failure;Height;Image;image archival system;International;Investigation;Leadership;Machine Learning;machine learning pipeline;Medicine;meetings;mHealth;Molecular;Monitor;Morbidity - disease rate;mortality;Multicenter Studies;multiple omics;National Heart, Lung, and Blood Institute;next generation;novel;novel strategies;Observational Study;Ontology;operation;Outcome;outreach;Participant;Patient-Focused Outcomes;Patients;phenomics;Phenotype;precision medicine;preservation;Prevalence;programs;prospective;Protocols documentation;recruit;remote consent;Research;Research Personnel;Research Priority;Resources;Sampling;Science;Site;skill acquisition;Standardization;statistics;Surveys;therapeutic target;tool;Trans-Omics for Precision Medicine;Translational Research;Translations;Universities;Validation;web based interface;working group

PROJECT_TITLE: HeartShare DeCODE-HF: Data translation center to Combine Omics, Deep phenotyping, and Electronic health records for Heart Failure subtypes and treatment targets


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine

PI_NAMEs: SHAH, SANJIV J (contact)

PROJECT_TERMS: Adipose tissue;advanced analytics;Affect;analytical tool;Applied Research;augmented intelligence;biobank;Biological Markers;Caring;catalyst;clinical investigation;Clinical Sciences;Clinical Trials;Cloud Computing;cohort;Communication;Communities;Complex;Consumption;Data;Data Collection;data de-identification;data integration;data portal;data resource;Data Science;Data Set;Data Sources;Data Storage and Retrieval;data visualization;Democracy;Development;Devices;Dimensions;Disparate;diverse data;Doctor of Philosophy;Echocardiography;Ecosystem;effective therapy;EFRAC;Electrocardiogram;Electronic Health Record;Ensure;Failure;FAIR principles;Fast Healthcare Interoperability Resources;frailty;frontier;Funding;Goals;Health;health data;Heart;Heart failure;Heterogeneity;Home;Image;improved;Individual;Informatics;Infrastructure;Insurance Carriers;Internet;interoperability;Investigation;Kidney;Lead;Leadership;Logical Observation Identifiers Names and Codes;Lung;medical schools;Medicine;member;mHealth;mobile application;Mobile Health Application;MRI Scans;Multiomic Data;multiple chronic conditions;multiple omics;Muscle;National Heart, Lung, and Blood Institute;novel;novel strategies;online repository;Online Systems;Participant;patient engagement;Patients;Phenotype;preservation;Privatization;programs;Qualifying;Registries;remote consent;Research;Research Personnel;Research Priority;Resources;sensor;skeletal tissue;stem;Strategic vision;Syndrome;Test Result;Testing;Therapeutic;tool;Trans-Omics for Precision Medicine;Translational Research;Translations;United States Agency for Healthcare Research and Quality;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Universities;Update;Visualization;web app;working group

PROJECT_TITLE: Data Portal Core


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_DEPT: PEDIATRICS

PHR: Allergic diseases and asthma are among the most common diseases, and are increasing for reasons that are not well understood. The goal of this program is to provide training in clinical and translational research to physician scientists who wish to pursue academic careers devoted to research, education and leadership in these critical areas of unmet medical need.

PI_NAMEs: GERN, JAMES E. (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Wisconsin Allergy Research Training (WISCART) Program

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: Project Narrative The embryonic ventral telencephalon is the developmental origin of numerous brain structures and cell populations such as the basal ganglia and cortical interneurons. These structures and cell populations are critical for higher brain functions and are often causally involved in neuropsychiatric disorders such as schizophrenia, autism, and drug addiction. By investigating the cellular and molecular mechanisms that control the developmental progression of neural progenitor cells in the ventral telencephalon, the proposed study will not only improve our understanding of brain development and brain function but also advance treatments of nervous system disorders.

PI_NAMEs: CAO, XINWEI  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Affect;Amygdaloid structure;Apical;autism spectrum disorder;Basal Ganglia;Binding;Bioinformatics;Biological;Biological Assay;Brain;Cell Count;Cell model;cell type;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;clinically relevant;cofactor;combinatorial;comparative;Complement;Complex;conditional knockout;Critical Pathways;data integration;Data Set;Development;Dissection;DNA Binding;DNA Binding Domain;Drug Addiction;Embryo;Enhancers;Exhibits;fly;Genes;Genetic;Genetic Transcription;Histologic;Homeostasis;improved;In Situ;In Situ Hybridization;in vivo;insulinoma associated 1;Interneurons;Knock-out;Knockout Mice;Knowledge;Ligation;Mammals;Medial;Mediating;Molecular;molecular marker;mouse model;Multipotent Stem Cells;Natural regeneration;nerve stem cell;Nervous System Disorder;nestin protein;neurodevelopment;neurogenesis;Neuroglia;Neurons;neuropsychiatric disorder;novel;Organ;Orthologous Gene;Output;Pathway interactions;Pattern;Phenotype;Population;progenitor;Property;Repression;Research;Role;Schizophrenia;Signal Pathway;single-cell RNA sequencing;Source;Specificity;stem cell population;Structure;synergism;Telencephalon;Testing;Tissues;Transcription Coactivator;transcription factor;Transcriptional Regulation;transcriptome sequencing;tumorigenesis

PROJECT_TITLE: Understanding the developmental progression of subpallial neural progenitor cells

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine

PROJECT_TERMS: advanced analytics;Artificial Intelligence;autism spectrum disorder;automated image analysis;biobank;Bioinformatics;Biological;Biological Markers;Cardiac;cardiometabolism;Cardiovascular Diseases;cardiovascular risk factor;career;catalyst;Characteristics;Classification;Clinical;cloud storage;cohort;Communication;Communities;Coupled;Data;Data Coordinating Center;data management;Data Pooling;data portal;Data Reporting;data resource;Data Sources;data standards;Dedications;deep learning;Detection;Development;Dimensions;Discipline;Disease;disorder subtype;Disparate;Echocardiography;EFRAC;Electrocardiogram;Electronic Health Record;Ensure;experience;experimental study;Foundations;Functional disorder;Goals;Health Technology;Heart failure;heart failure with reduced ejection fraction;Home;Image;image archival system;Individual;innovation;Investigation;Kidney;Leadership;Lipids;Machine Learning;mHealth;Modeling;Molecular Probes;Monitor;Multicenter Studies;multiple omics;National Heart, Lung, and Blood Institute;Natural Language Processing;novel;open data;operation;Organ;Outcome;Pathway interactions;Patient Self-Report;Patients;Phenotype;phenotypic data;precision medicine;preservation;Procedures;programs;Proliferating;prospective;Reporting;Research;Resistance;Resource Sharing;Resources;statistics;Structure;Syndrome;Systems Biology;Techniques;Therapeutic;therapeutically effective;tool;Trans-Omics for Precision Medicine;Translations;Ventricular;Visualization;Work

PROJECT_TITLE: Data Management Core


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative A growing number of repeat expansion disorders have been shown to accumulate toxic repeat- associated non-ATG (RAN) proteins in patient neurological tissues. This proposal will characterize the accumulation of RAN proteins across multiple CAG·CTG repeat expansion disorders using novel repeat-specific antibodies. Additionally, we have designed AAV and small molecule approaches aimed at the protein kinase R (PKR) pathway to inhibit RAN translation. Using these tools we will test our central hypotheses that RAN protein pathology is a common feature shared across CAG·CTG expansion disorders and that inhibiting the protein kinase R pathway will reduce RAN protein levels and mitigate disease.

PI_NAMEs: BANEZ-CORONEL, MONICA ;RANUM, LAURA P.W (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: 3' Untranslated Regions;Affect;Antibodies;Ataxia;Autopsy;Bacterial Artificial Chromosomes;Behavioral;Brain;C-terminal;C9ORF72;CAG repeat;Categories;Cells;Collection;CRISPR/Cas technology;Cultured Cells;design;Development;Disease;Disease Progression;experimental study;FDA approved;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Genetic;genetic approach;Human;human disease;human tissue;Huntington Disease;improved;in vivo;Individual;induced pluripotent stem cell;inhibitor;insight;Introns;Knock-in Mouse;Length;LY6E gene;Metformin;MJD1 protein;Molecular;Mus;Mutation;Neurologic;Neurons;neuropathology;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Open Reading Frames;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;polyglutamine;Protein Biosynthesis;protein kinase R;Proteins;Reading Frames;RNA;Severity of illness;Site;small molecule;Spinocerebellar Ataxias;Testing;Therapeutic;Time;Tissues;tool;Toxic effect;Transcript;transcriptomics;Transgenic Organisms;Translations

PROJECT_TITLE: Contribution of RAN proteins to HD, SCA3 other CAG.CTG expansion diseases

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Heart Disease;Patient Safety

ORG_CITY: SEATTLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Heart failure (HF) care is costly, complex, and often fragmented which impacts quality of care, safety, and other patient outcomes. Structured interprofessional bedside rounds (SIBR)—a model that was developed to bring together health professionals and patients using a structured format to collaboratively arrive at a daily plan of care—has been associated with improvements in many care team and patient outcomes but model fidelity (adherence) varies. Rigorous study of SIBR fidelity when analyzing impacts on care and outcomes is needed to determine whether and how SIBR can reliably lead to improvements.

PI_NAMEs: BLAKENEY, ERIN LINDSEY (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Active Learning;Address;Adherence;Adopted;Adult;Adverse event;Affect;American;Caring;Characteristics;Childhood;Clinical Pathways;Clinical Research;Collaborations;Communication;Complex;cost;Data;design;Development;Disparity;disparity reduction;Electronic Health Record;empowerment;Evaluation;Event;evidence base;experience;Family;Family member;Foundations;Funding;Future;Goals;Grant;Health;Health Policy;Health Professional;Heart failure;Heart Transplantation;Heart-Assist Devices;hospital readmission;Hospitalization;Hospitals;Implant;implementation evaluation;implementation science;improved;innovation;Inpatients;Intervention;Intervention Studies;Interview;Knowledge;Lead;Length of Stay;Linear Models;Link;Managed Care;Medical;Medical center;member;Mentors;Mentorship;Methods;Modeling;National Heart, Lung, and Blood Institute;novel;Observational Study;Outcome;Outcomes Research;Palliative Care;Pathway interactions;Patient Admission;Patient Care;patient engagement;patient oriented;Patient-Centered Care;Patient-Focused Outcomes;Patients;Play;Policy Maker;Population;Positioning Attribute;Postdoctoral Fellow;Prospective, cohort study;Quality of Care;Questionnaires;readmission rates;Regression Analysis;Reporting;Research;Research Design;Research Methodology;Research Personnel;Resolution;Role;Safety;Sampling;satisfaction;Site;standard of care;Structure;success;Survival Rate;System;Testing;Time;Training;Universities;Variant;Washington;Work

PROJECT_TITLE: Implementation and Sustainment of Team-Based Practice Transformation to Improve Heart Failure Care and Outcomes

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lead Poisoning;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project narrative Ensuring healthy neurodevelopment for children can lead to tremendous societal gain. We propose a modeling framework that can improve our understanding of how early life factors impact neurodevelopment, which could inform targeted prevention and intervention strategies.

PI_NAMEs: LIU, SHELLEY HAN (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Advisory Committees;Affect;Age;Biological;Biometry;Birth;Boston;career;Child;Childhood;Cities;Clinical;Cognitive;cognitive skill;cohort;Committee Members;Communities;Complement;Complex;Computer software;Data;Development;Dimensions;Dose;Ensure;Environment;environmental stressor;Equation;executive function;Factor Analysis;Factor V;fetal lead exposure;flexibility;Funding;Genetic;Goals;Growth;Health Policy;Health Sciences;improved;Individual;interest;International;Intervention;Joints;Knowledge;Lead;lead exposure;Letters;Life;Life course epidemiology;Link;Literature;low socioeconomic status;Machine Learning;machine learning model;maternal stress;Measurement;Measures;medical schools;meetings;Mentors;Methods;Mexico;Modeling;multimodality;neurobehavior;neurobehavioral;neurodevelopment;Neuropsychology;New York City;nutrition;open source;Output;population health;postnatal;Predictive Factor;prenatal;prevent;Prevention;Prevention strategy;Process;professor;programs;prospective;Psychometrics;Research;Research Personnel;response;Risk Factors;Role;Rotation;Short-Term Memory;skills;social;social stressor;Socioeconomic Status;software development;statistics;Structure;success;Task Performances;Testing;theories;Time;tool;Training;United States National Institutes of Health;user friendly software;Variant;web app

PROJECT_TITLE: Improving precision in modeling childhood executive function trajectories using psychometrics

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

PROJECT_TERMS: Artificial Intelligence;augmented intelligence;Award;Biological;Cardiology;cardiovascular disorder epidemiology;Cardiovascular system;clinical center;Clinical Data;Clinical Investigator;Clinical Trials;Cohort Studies;Collaborations;Complex;computer science;Data;data acquisition;Data Analyses;Data Collection;Data Coordinating Center;data repository;Data Scientist;data standards;design;EFRAC;Electronic Health Record;Enrollment;Ensure;epidemiology study;Equipment;experience;Fellowship Program;follow-up;Follow-Up Studies;Funding;Genome;Goals;Greenland;health data;Heart;Heart failure;heart failure with reduced ejection fraction;Human Resources;Industry;Infrastructure;innovation;Institution;International;Laboratories;Leadership;Medicine;Mentors;mHealth;Modeling;Monitor;Multicenter Studies;National Heart, Lung, and Blood Institute;Observational Study;outreach;participant enrollment;patient retention;Patients;phenome;Phenotype;Postdoctoral Fellow;preservation;Process;programs;prospective;Protocols documentation;Qualifying;Records;Research;Research Personnel;Resources;Site;skills;skills training;Source;Standardization;Syndrome;synergism;Trans-Omics for Precision Medicine;Translations;United States National Institutes of Health;Universities

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Genetics;Human Genome;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: RALEIGH

ORG_DEPT: BIOLOGY

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Narrative. Over the last 30 years, the rapid increase in the prevalence of the cluster of conditions such obesity, high blood pressure and elevated lipids in children has led to the hypothesis that the epigenetic mechanisms required to adjust to ever-increasing environmental exposures contribute to obesity outcomes; however, epigenetic regions that alter obesity risk are still unknown. We recently identified human imprinted gene control regions throughout the genome, and our goal is to now develop a custom chip to measure DNA methylation of these regions, and determine whether we can use them to predict at birth those children who will develop these diseases and the extent to which environmental chemicals contribute to their formation. Doing so will allow the scientific community to determine of role of genomic imprinting in the mechanistic origins of these chronic diseases.

PI_NAMEs: HOYO, CATHRINE  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: 5 year old;Adolescent;Affect;Age;aged;Alanine Transaminase;Alleles;Bioinformatics;Biological Assay;Birth;bisulfite sequencing;Blood Pressure;Body mass index;Body measure procedure;Cadmium;cell type;Cells;Central obesity;Child;Childhood;Chromatin Structure;Chronic Disease;clinically actionable;cohort;Communities;comorbidity;Consensus;CpG dinucleotide;Cues;Custom;Cytosine;Data;deep sequencing;Deposition;Desire for food;Development;Disease;DNA;DNA Methylation;Early Diagnosis;Ectoderm;Elements;Embryo;Embryonic Development;Endoderm;environmental chemical;Environmental Exposure;Environmental Pollutants;Epidemiology;Epigenetic Process;epigenome;Exposure to;Fatty acid glycerol esters;fetal;Functional disorder;Gene Dosage;Gene Expression;Genes;Genetic;genetic variant;Genome;genome-wide;Genomic Imprinting;Germ Cells;Germ Layers;Goals;GRB10 gene;Growth;Growth Disorders;H19 gene;Health;Heavy Metals;histone modification;Human;Human Genome;human tissue;Hyperglycemia;Hyperlipidemia;Hypertension;IGF2 gene;imprint;Individual;interest;Knowledge;Life;Life Cycle Stages;Link;Lipids;Liver Dysfunction;Maps;Measurement;Measures;Mediating;Mesoderm;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Methods;Methylation;Modification;Molecular Profiling;non-alcoholic fatty liver disease;novel;Nucleic Acid Regulatory Sequences;Nutrient;Obesity;obesity risk;offspring;Outcome;Parents;Pathway interactions;Peripheral;Placenta;PLAGL1 gene;prehypertension;prenatal;prenatal exposure;preservation;Prevalence;Protocols documentation;Proxy;Records;Reporting;response;Role;Sampling;Satiation;Screening procedure;Site;Somatic Cell;Specific qualifier value;Specimen;Testing;Tissues;toxic metal;Trace metal;Triglycerides;whole genome

PROJECT_TITLE: Novel imprint control regions (ICRs) responsive to environmental exposures

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative  Spatial transcriptomics is a groundbreaking new technology that allows measurement of gene ac- tivity in a tissue sample while mapping where the activity is occurring. Successful proﬁling of spatial gene expression can signiﬁcantly advance the frontier of transcriptomics research and associate these variations with human health and diseases. The aim of this proposal is to develop bioinformatics in- frastructures and computational tools for spatial transcriptomics studies.

PI_NAMEs: CHEN, MENGJIE  (contact);ZHOU, XIANG

PROGRAM_OFFICER_NAME: GAO, JEAN XUEJING

PROJECT_TERMS: Achievement;Address;Architecture;Awareness;bioinformatics infrastructure;Biological;Breast Cancer Patient;Case/Control Studies;Cell Culture Techniques;Clinical Research;cohort;Collection;Communities;Computer software;computerized data processing;computerized tools;Data;Data Analyses;Data Set;Data Sources;deep learning;deep neural network;Detection;Development;digital;dimension reduction;Dimensions;Disease;Event;falls;Foundations;frontier;Gene Expression;Genes;genomic data;Genomics;Goals;Health;Heterogeneity;histological image;Human;Image;Immune response;innovation;Investigation;Joints;Link;Location;Malignant Neoplasms;Maps;Measurement;Methodology;Methods;multiple data sources;Neurodegenerative Disorders;new technology;novel;open source;Pattern;Performance;phase II trial;Phenotype;Property;rapid detection;Research;Resolution;Sample Size;Sampling;simulation;single-cell RNA sequencing;Slide;Software Tools;Structure;Technology;technology platform;tissue culture;Tissue Sample;Tissues;tool;Training;transcriptomics;transfer learning;translational study;Treatment outcome;user friendly software;user-friendly;Validation;Variant;Work

PROJECT_TITLE: Developing new computational tools for spatial transcriptomics data

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Dissemination and Implementation Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Approximately one million women undergo an induction of labor in the US annually and more than one-third of these inductions end in cesarean delivery (CD). We propose a large (2300 women), multicenter, pragmatic, randomized trial to test the central hypothesis that outpatient cervical ripening with a Foley catheter will 1) decrease the primary CD rate and 2) reduce maternal and neonatal morbidity. Given the long time-lag between effectiveness studies and widespread implementation, we will additionally explore barriers and facilitators to implementation to enable rapid uptake and dissemination of our findings with a Type 1 hybrid effectiveness- implementation trial.

PI_NAMEs: CAHILL, ALISON G;LEVINE, LISA DANIELLE (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Abnormal placentation;arm;Birth;care delivery;Caring;Catheters;Cervical Ripening;Cesarean section;Client satisfaction;cost;COVID-19 pandemic;Data;Diagnosis;Diagnostic;Dissemination and Implementation;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness study;effectiveness/implementation study;effectiveness/implementation trial;Endometritis;Exposure to;Future;Goals;health care service utilization;Health system;Hemorrhage;Home;hospital readmission;Hospitals;Hypoglycemia;implementation determinants;implementation facilitators;improved;improvement on sleep;Induced Labor;Infection;innovation;Inpatients;insight;Internal Medicine;Intervention;Interview;Label;Labor Dystocia;maternal morbidity;maternal outcome;maternal risk;Measures;Medical;Meta-Analysis;Methods;Morbidity - disease rate;Multicenter Trials;Neonatal;neonatal hypoxic-ischemic brain injury;neonatal morbidity;novel;Nulliparity;Nurses;Outpatients;parous;Patients;Perception;pragmatic randomized trial;Pregnancy;Procedures;Process;Provider;Public Health;Publishing;Randomized;randomized trial;Relaxation;Resources;Respiratory distress;Risk;Risk Reduction;Safety;safety outcomes;satisfaction;Sepsis;Shapes;standard of care;Surveys;Testing;Time;Transfusion;uptake;venous thromboembolism;Visit;Woman;Wound Infection

PROJECT_TITLE: A multicenter pragmatic randomized trial evaluating effectiveness and safety of outpatient Foley catheter for cervical ripening in nulliparous women: a Type 1 hybrid effectiveness-implementation study

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

ORG_STATE: MD

PHR: PROJECT NARRATIVE – OVERALL The Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) will develop and conduct innovative behavioral, community-based, translational, therapeutic, microbicide, and vaccine trials in youth ages 13-24 at risk for HIV and living with HIV, with a focus on the inclusion of minors. This initiative will center on collaboratively conducted interventional research aimed at reducing new HIV infections and investigating HIV treatments in this disproportionately medically underserved, gender and racial/ethnic minority, and/or substance abusing youth population. The ATN OCC will facilitate transdisciplinary research through organizational leadership and collaboration support for the ATN-specific agenda that will address substantial and disproportionate gaps in health outcomes across the HIV prevention and care continuum for youth.

PI_NAMEs: DRIVER, BARBARA  (contact);REIRDEN, DANIEL HUNTER

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Address;Adherence;Adolescent;Adolescent and Young Adult;adolescent health outcomes;Adolescent Medicine Trials Network;adolescent substance abuse;Affect;Age;AIDS prevention;Alaska Native;American Indians;antiretroviral therapy;Behavioral;Black race;Budgets;Clinical Trials;Collaborations;Communication;Communities;Continuity of Patient Care;design;Dropout;Enrollment;Ensure;Epidemiology;equity, diversity, and inclusion;ethnic minority;experience;gender minority;Geographic Locations;Geography;Health;HIV;HIV diagnosis;HIV Infections;HIV/AIDS;improved;Infection;Infrastructure;innovation;Intervention;Intervention Studies;Latino;Leadership;Life Cycle Stages;Maintenance;Manuals;Measures;Medical;medically underserved;meetings;men who have sex with men;microbicide;Midwestern United States;Minor;Mission;Monitor;multi-racial;Office of Administrative Management;operation;Outcome;Participant;pediatric human immunodeficiency virus;Performance;performance site;Pharmacologic Substance;Population;Positioning Attribute;pre-exposure prophylaxis;Procedures;programs;Protocols documentation;Qualifying;quality assurance;Quality Control;racial minority;recruit;Regimen;Reporting;Research;Research Personnel;Resources;Risk;Safety;Science;screening;Site;Specimen;success;symposium;System;Therapeutic;timeline;Training;transmission process;underserved minority;United States;United States National Institutes of Health;vaccine trial;Vendor;web site;Work;Youth

PROJECT_TITLE: Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: PAUL, MARY E (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adolescent and Young Adult;Adolescent Medicine Trials Network;Advisory Committees;Advocate;Affect;African American population;age group;AIDS prevention;Area;Black race;Caring;case-based;Cities;Clinical Trials;Collaborations;college;Communities;community advisory board;community engagement;community organizations;Conduct Clinical Trials;County;COVID-19;COVID-19 pandemic;design;Development;Discipline of Nursing;Drug Kinetics;Epidemic;ethnic minority population;Evaluation;experience;Failure;Feedback;Future;gender minority youth;Goals;Health;health inequalities;Healthcare;Heterosexuals;high risk;Hispanic;HIV;HIV diagnosis;HIV Infections;HIV/AIDS;Homeless Youth;Human immunodeficiency virus test;human old age (65+);Human Resources;improved;improved outcome;Individual;Infection;innovation;Intervention;Laboratories;Latino;Latinx;Lead;Leadership;Low income;male;marginalized community;Medicaid;Medical;Medicine;meetings;member;Minority Groups;Modality;Modeling;motivational enhancement therapy;Newly Diagnosed;novel strategies;Online Systems;operation;Outcome;outreach;participant enrollment;Pediatric Hospitals;Pharmacy facility;pre-exposure prophylaxis;prevent;Prevention;prevention service;programs;racial minority;recruit;Reporting;Research;research study;Risk;Services;sexual minority group;Site;Structure;Technology;testing services;Texas;transmission process;Treatment Effectiveness;treatment services;Uninsured;United States;uptake;Work;Youth

PROJECT_TITLE: Baylor College of Medicine Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: BELZER, MARVIN E (contact)

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;Adolescent Medicine Trials Network;Adult;adult of color;Advisory Committees;Advocacy;anti-racism;Area;California;care systems;Caring;CCL21 gene;Child;children of color;Cities;Clinic;Clinical;Clinical Research;clinical research site;Clinical Services;Clinical Trials;Clinical Trials Network;Cohort Studies;Collaborations;Communities;community advisory board;community based service;community engagement;community organizations;community partners;community partnership;Complex;County;Databases;design;Development;Education;epidemic preparedness;experience;Family;Funding;Future;Gays;gender diverse;Goals;Government;Health;HIV;HIV/AIDS;HIV/STD;Homelessness;Hospitals;innovation;Intervention;Investigational Drugs;Laboratories;Laboratory Research;Latinx;Lead;Leadership;lens;Lesbian;Lesbian Gay Bisexual Transgender Queer;Los Angeles;Medical;Medicine;Mental Health Services;Modeling;multidisciplinary;National Institute of Child Health and Human Development;National Institute of Drug Abuse;operation;participant enrollment;Pediatric Hospitals;people of color;Pharmaceutical Services;Pharmacy facility;positive youth development;Prevention;prevention service;programs;protocol development;Protocols documentation;Public Health;recruit;Research;Research Project Grants;research study;Risk;Secure;Services;sex;Site;Structure;substance use prevention;transgender;treatment services;Universities;Work;young adult;young man

PROJECT_TITLE: Children's Hospital Los Angeles Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)


ORG_CITY: PHOENIX

ORG_NAME: TRANSLATIONAL GENOMICS RESEARCH INST

ORG_STATE: AZ

PHR: Project Narrative Identifying multi-omic QTLs at cell-type resolution is critical for advancing the field of functional genomics and improving our understanding of the genetic architecture of complex disease. However, we currently lack methods to identify QTLs from single cell ‘omics data and there are no available methods for identifying multi- omic QTLs. We aim to develop, validate, and deploy these methods using data from primary human lung tissue and PBMCs collected from patients with pulmonary fibrosis and healthy controls.

PI_NAMEs: BANOVICH, NICHOLAS ELI (contact);MCCARTHY, DAVIS JAMES

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Adoption;Age;Allelic Imbalance;Architecture;Automobile Driving;Benchmarking;biobank;Biological;Blood;cell type;Cells;Characteristics;Chromatin;Communities;Complex;Computational Biology;Computer software;computerized data processing;computerized tools;Data;Data Analyses;Data Collection;Disease;DNA Methylation;flexibility;Foundations;functional genomics;functional improvement;Gene Expression;Gene Expression Regulation;Generations;Genes;genetic architecture;Genetic study;Genetic Transcription;Genetic Variation;genome wide association study;genome-wide;Genomic approach;genomic data;genomic platform;Genomics;Genotype;Goals;High-Throughput Nucleotide Sequencing;histone modification;Human;human genomics;human tissue;improved;In Vitro;Individual;insight;Lung;Maps;Messenger RNA;method development;Methods;Modeling;Modernization;Molecular;multiple omics;Normal tissue morphology;novel;open source;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Phenotype;Positioning Attribute;Process;Proliferating;Proteins;Pulmonary Fibrosis;Quantitative Trait Loci;Research Personnel;Resolution;risk variant;Role;Sampling;single cell ATAC-seq;single cell genomics;single cell proteins;single cell technology;single-cell RNA sequencing;Specificity;Stress;Structure of parenchyma of lung;System;Techniques;Technology;Testing;Tissues;tool;transcriptomics;Variant;Work

PROJECT_TITLE: Integrated analysis of multi-omic QTLs at single cell resolution


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Sexually Transmitted Infections

PI_NAMEs: RAKHMANINA, NATELLA YURIEVNA (contact)

PROJECT_TERMS: Academy;Acquired Immunodeficiency Syndrome;Adolescent;Adolescent and Young Adult;Adolescent Medicine Trials Network;Adult;age group;aged;AIDS prevention;American;antiretroviral therapy;Area;Assessment tool;Behavioral Sciences;Black race;Capital;care systems;Caring;Child;Childhood;Chlamydia;Clinical;clinical center;Clinical Sciences;Clinical Trials;Cohort Studies;Collaborations;Communities;community engagement;community organizations;cooking;Counseling;County;Data;Development;District of Columbia;Eligibility Determination;Enrollment;Ensure;Epidemic;European;Funding;Goals;Gonorrhea;Guidelines;Health;Health Services Accessibility;high school;HIV;HIV diagnosis;HIV Infections;HIV prevention trials network;HIV-infected adolescents;HIV/AIDS;Hospitals;Hotlines;Human immunodeficiency virus test;implementation science;Incidence;Industry;Infection;innovation;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;Investigational Drugs;Laboratories;Leadership;Maryland;Methodology;metropolitan;Minority;Modeling;National Children's Study;novel;operation;Outcome;Participant;Pediatric HIV/AIDS Cohort Study;pediatric human immunodeficiency virus;Pediatrics;peer support;Pharmacy facility;Physicians;poor health outcome;Positioning Attribute;pre-exposure prophylaxis;Prevalence;prevent;Prevention;prevention service;Productivity;programs;Psychosocial Assessment and Care;Public Health;Publishing;Readiness;Recording of previous events;recruit;Research;Research Personnel;Risk;Role;Schools;screening;Sexually Transmitted Diseases;Site;Social Sciences;Teletherapy;testing services;tool;treatment services;United States;United States Dept. of Health and Human Services;United States National Institutes of Health;Washington

PROJECT_TITLE: Children's National Hospital Site Consortium  - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Mental Health;Mental Illness;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PUBLIC HEALTH NARRATIVE Anxiety sensitivity, reflecting the fear of bodily sensations, is a risk factor for the maintenance and relapse of smoking. This study is designed to address the question – is a smoking cessation intervention personalized to high anxiety sensitive smokers and adapted for implementation by the YMCA effective among racially/ethnically diverse samples? This protocol provides recommended treatment to achieve cessation and randomizes individuals to high-intensity exercise vs. low intensity exercise as a strategy to engage the mechanisms relevant to high anxiety sensitive smokers to improve smoking cessation outcomes.

PI_NAMEs: CHENEY, MARSHALL ;SMITS, JASPER  (contact);ZVOLENSKY, MICHAEL J.

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: Abstinence;Address;Adult;Affect;Affective;Anxiety;Anxiety Disorders;anxiety reduction;anxiety sensitivity;anxiety symptoms;Black race;bodily sensation;burden of illness;Caring;Cessation of life;cigarette smoking;Communities;community based evaluation;community based treatment;community intervention;comorbidity;Control Groups;Counseling;demographics;depressive symptoms;design;Diagnostic;disability;Discrimination;Disease;Distress;dysphoria;Education;efficacy evaluation;efficacy research;efficacy study;efficacy trial;Emotional disorder;Esthesia;ethnic diversity;ethnic minority;Ethnic Origin;Ethnic Population;Etiology;evidence base;Exercise;exercise intensity;exercise prescription;Exposure to;Failure;follow-up;Fright;General Population;Heart Rate;implementation framework;improved;Individual;instructor;Intervention;intervention effect;Interview;Investigational Therapies;Latinx;Literature;long term abstinence;low socioeconomic status;Maintenance;Mediating;Mediator;Mental Depression;Minority;Modeling;Moods;negative affect;negative mood;nicotine craving;Nicotine Dependence;nicotine replacement;Nicotine Withdrawal;Outcome;Participant;perceived discrimination;personalized intervention;Phase;phase 3 study;phase III trial;Prevalence;prevent;preventable death;Process;process evaluation;programs;Protocols documentation;Provider;Psychopathology;Public Health;quality assurance;quitline;Race;racial diversity;racial minority;racial population;racism;Randomized;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Relapse;Reporting;Research;Risk;Risk Factors;Sampling;Smoke;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;smoking prevalence;smoking relapse;Smoking treatment;Social support;Societies;Stress;stress symptom;Symptoms;Syndrome;Testing;therapy development;Tobacco;trial comparing;United States;Work

PROJECT_TITLE: Efficacy and implementation of exercise-based smoking cessation treatment for adults with high anxiety sensitivity

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SIMPSON, KAREN  (contact)

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;Address;Adolescent;Adolescent and Young Adult;Adolescent Medicine Trials Network;adolescent substance abuse;Affect;Age;AIDS prevention;Area;Articulation;Award;Awareness;Black race;Caring;Catchment Area;Chicago;Cities;Clinic;Clinical;Clinical Trials;Collaborations;combat;Communities;community collaboration;community engagement;Community Health Networks;community organizations;Community Outreach;community partners;Continuity of Patient Care;Contracts;cooking;County;detention center;Development;Diagnosis;Diagnostic;Education;emtricitabine;Epidemic;ethnic minority;Event;experience;Foundations;Fumarates;gender minority group;Goals;Grant;Health;Health education;Health system;Healthcare;High Prevalence;high risk;Hispanic;HIV;HIV diagnosis;HIV Infections;HIV-infected adolescents;HIV/AIDS;Hospitals;Illinois;implementation intervention;improved;Individual;Infection;infection rate;Infectious Diseases Research;innovation;Intervention;Intervention Studies;Laboratories;Leadership;Longitudinal cohort study;low socioeconomic status;Medical Research;medically underserved;meetings;men who have sex with men;Methods;Midwestern United States;minority communities;Modeling;multidisciplinary;new technology;operation;Participant;Patients;Pediatric Hospitals;Persons;Pharmacy facility;pre-exposure prophylaxis;Prevalence;Prevention;Prevention approach;Prevention strategy;preventive intervention;Primary Prevention;Productivity;programs;Provider;Public Health;racial minority;Recording of previous events;recruit;Research;Research Project Grants;research study;Research Support;Risk;Safety;safety net;Secondary Prevention;Services;Sexual Health;sexual minority group;Sexually Transmitted Diseases;Side;Site;Structure;Tenofovir;tertiary prevention;Testing;United States;Universities;virtual;Vulnerable Populations;Washington;Work;Youth

PROJECT_TITLE: The Hektoen Institute of Medical Research Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Humans and other animals organize themselves into social groups in which each member both contributes to and benefits from the well-being of the whole, especially in the presence of environmental challenges—however little is known about how group level interactions are coordinated by neural circuits. Using cutting-edge tools for automated behavior tracking and neural circuit dissection, this proposal will examine how medial prefrontal cortex projections regulate group behaviors during environmental stress. This research will enhance our understanding of how social behaviors at the level of the group are coordinated by the brain, and will pave the way for more effective therapeutic strategies to combat social response to challenge and stress in humans.

PI_NAMEs: RAAM, TARA  (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Address;Anatomy;Animals;autism spectrum disorder;Automobile Driving;Behavior;Behavioral;behavioral study;Biological;Biological Assay;Brain;Brain region;Buffers;Calcium;Cells;cognitive capacity;cold stress;cold temperature;combat;Communication;Complex;Computer Models;Computer Vision Systems;Data;Decision Making;designer receptors exclusively activated by designer drugs;Detection;Disease;Dissection;Emotional;environmental stressor;experimental study;Foundations;Genetic;genetic manipulation;Health;Hormones;Human;Hypothalamic structure;Image;Impairment;in vivo;in vivo imaging;Individual;Investigation;Knock-out;Laboratory Study;Lateral;Literature;Maps;Medial;Mediating;member;Mental disorders;Mental Health;Mus;neural;neural circuit;Neurodevelopmental Disorder;neuromechanism;Neurons;Neuropeptides;novel;novel strategies;Nucleus Accumbens;Oxytocin;Pathway interactions;Personal Satisfaction;Phase;Physiological;Population;Prefrontal Cortex;Problem Solving;Productivity;Publishing;Regulation;Research;Research Personnel;Resource Sharing;response;Role;Schizophrenia;self organization;Shapes;Signal Transduction;social;Social Behavior;Social Environment;Social Functioning;social group;Social Interaction;statistical and machine learning;Stress;stress management;stressor;Symptoms;Technical Expertise;Technology;Temperature;Testing;Thalamencephalon;therapeutically effective;tool;Training;Virus;virus genetics;Work

PROJECT_TITLE: Neural basis of collective behavior during environmental stress


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Primary Health Care;Social Determinants of Health

PI_NAMEs: MAYER, KENNETH H (contact)

PROJECT_TERMS: Address;Adolescent Medicine Trials Network;Age Years;authority;behavioral health;behavioral study;Boston;Caring;Clinical Trials;Clinical Trials Design;Collaborations;Communication;community advisory board;community engagement;Community Health Education;Conduct Clinical Trials;Contracts;County;design;Drops;Enrollment;Ensure;Epidemic;Federally Qualified Health Center;Funding;gender minority youth;Goals;Grant;harm reduction programs;Health;Health system;HIV;HIV Seropositivity;HIV/AIDS;Housing;Human Resources;improved;Infrastructure;Injecting drug user;innovation;Intervention;Investigational Drugs;Justice;Laboratories;Leadership;Legal;Massachusetts;Mediation;Medical;meetings;member;Monitor;Neighborhood Health Center;New England;New Hampshire;operation;participant retention;Pharmacy facility;Phase;Prevention;Primary Care;Process;programs;Protocols documentation;Public Health;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Risk;Schools;screening;sexual minority youth;Sexually Transmitted Diseases;Site;social health determinants;System;transmission process;Work;Youth

PROJECT_TITLE: Fenway Community Health Center, Inc., Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention

PI_NAMEs: AGWU, ALLISON L (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescent;Adolescent and Young Adult;adolescent health outcomes;Adolescent Medicine;Adolescent Medicine Trials Network;Adult;Advocate;Age;Age Years;AIDS clinical trial group;antiretroviral therapy;Baltimore;Black race;Caring;Childhood;Clinical;clinical care;Clinical Research;Clinical Trials;Clinical Trials Design;Clinical Trials Network;cohort;Collaborations;Communicable Diseases;Communities;Community Networks;community organizations;Continuity of Patient Care;Data Collection;design;Development;Disease Progression;disease transmission;disorder risk;Disparity;Drug Kinetics;empowerment;Ensure;epidemic preparedness;Equity;experience;Failure;Funding;Goals;Government;Hispanic;HIV;HIV diagnosis;HIV Infections;HIV-infected adolescents;HIV/AIDS;Home;improved;Industry;Infrastructure;innovation;Institution;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;Intervention Studies;Investigational Drugs;Latinx;Lead;lens;Lived experience;marginalization;Maryland;member;multidisciplinary;novel;operation;Outcome;Outcomes Research;Persons;Policies;Policy Maker;Population;Prevention;Productivity;programs;protocol development;Public Health;recruit;Research;Research Activity;Research Infrastructure;Research Personnel;retention rate;Risk;Science;Site;Social Behavior;State Government;success;synergism;Testing;Translational Research;Underrepresented Populations;United States;Universities;Vaccines;Viral;virtual;Voice;young adult;Youth

PROJECT_TITLE: Johns Hopkins University Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative  This project would be the first to test in humans a central hypothesis derived from animal models related to a mechanism underlying the antidepressant effects of ketamine. We will test in patients with treatment resistant depression whether the neural and antidepressant effects of ketamine are prevented by pretreatment with an antagonist of the amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptor (AMPAR).

PI_NAMEs: DRIESEN, NAOMI R (contact);HYDER, DEWAN SYED FAHMEED;KRYSTAL, JOHN H.

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Acids;AMPA Receptors;Anesthetics;Animal Model;antagonist;anti-depressive agents;antidepressant effect;Attenuated;base;Biological;Biological Markers;Brain;Calibration;Cerebral cortex;Cerebrum;Clinical;clinically significant;Crossover Design;Data;density;depression model;depressive symptoms;disability;Distress;Dose;Excitatory Amino Acid Antagonists;FDA approved;follow-up;Functional Magnetic Resonance Imaging;Glutamate Receptor;Glutamates;Half-Life;Hamilton Rating Scale for Depression;Hour;Human;imaging biomarker;Impairment;improved;Individual;information gathering;Infusion procedures;intravenous administration;Ketamine;Literature;Maps;Measures;Medial;Mental Depression;Metabolic;metabolic rate;N-Methylaspartate;neural;Neurobiology;Neuronal Plasticity;Oxygen;Patients;Pharmaceutical Preparations;Placebos;pre-clinical research;preclinical study;prevent;Receptor Activation;response;Rest;restoration;Safety;Saline;single episode major depressive disorder;Symptoms;Synapses;Testing;Therapeutic;Therapeutic Effect;Time;treatment-resistant depression

PROJECT_TITLE: AMPA Receptor Components of the Antidepressant Response to Ketamine in Humans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-B(90)M]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: GAUR, ADITYA H (contact)

PROJECT_TERMS: Academia;Acquired Immunodeficiency Syndrome;Address;Adolescent;Adolescent Medicine;Adolescent Medicine Trials Network;African American population;Age;Area;Arkansas;Behavioral;Black Populations;Cities;Clinic;Clinical;clinical development;Clinical Research;clinical research site;clinical trial implementation;Clinical Trials;Clinical Trials Design;Collaborations;Communities;community advisory board;community organizations;community partners;community partnership;comorbidity;County;design;Development;Diagnosis;Epidemic;Fortification;Funding;General Population;Geography;Health;Healthcare;HIV;HIV Infections;HIV/AIDS;Human Resources;Income;Individual;Infection;infection rate;Infrastructure;innovation;interest;Intervention;Intervention Studies;Investments;Laboratories;Leadership;meetings;metropolitan;microbicide;Minor;Mississippi;Missouri;Names;novel;novel strategies;operation;pandemic disease;Persons;Pharmacy facility;Policies;Population;Poverty;prevent;Public Health;Radial;recruit;research facility;Research Infrastructure;Research Personnel;Risk;rural area;Saint Jude Children's Research Hospital;Schools;Site;Strategic Planning;Tennessee;Therapeutic;Thinking;United States;Universities;urban area;vaccine trial;virtual;Writing;Youth

PROJECT_TITLE: St. Jude Children's Research Hospital - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS

PI_NAMEs: ABDALIAN, SUE ELLEN (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Administrator;Adolescent;Adolescent Medicine;Adolescent Medicine Trials Network;Advertisements;Advocacy;Appointment;artist;Back;biobehavior;Biomedical Research;children of color;Clinic;Clinical;clinical research site;Clinical Trials;Collaborations;Communities;community advisory board;community collaboration;community organizations;Community Outreach;Complex;Dancing;Data Storage and Retrieval;Decision Making;design;Development;Education;Enrollment;Ensure;Epidemic;Ethics;Event;experience;feasibility research;Feedback;Funding;Gays;gender diverse;Goals;Government Agencies;Health;Hepatitis;High Prevalence;HIV;HIV-infected adolescents;HIV/AIDS;HIV/STD;Hot Spot;implementation strategy;Incidence;innovation;Instagram;Institution;interest;Intervention;Intervention Studies;Investigational Drugs;Laboratories;Leadership;Link;Louisiana;Marketing;medical schools;meetings;member;Modeling;Monitor;operation;outreach;Participant;Patient Recruitments;pediatric department;Persons;Pharmacy facility;Policies;Process;Productivity;programs;Protocols documentation;Recording of previous events;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;research study;retention rate;Risk;Sampling;Secure;Services;Site;social media;Solid;Training;Trust;Universities;Update;Visit;Walking;Work;Youth

PROJECT_TITLE: The Administrators of the Tulane Educational Fund dba TUHSC Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Tri


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Vaccine Related

PI_NAMEs: EMMANUEL, PATRICIA J (contact)

PROJECT_TERMS: Address;Adolescent and Young Adult;adolescent health;Adolescent Medicine Trials Network;Age;AIDS prevention;antiretroviral therapy;Area;arm;Bay Region;Behavior Therapy;Behavioral;Caring;Childhood;Clinic;Clinical;clinical infrastructure;clinical translation;Clinical Trials;Collaborations;Communication;Communities;community based research;community empowerment;Community Participation;comorbidity;County;COVID-19 vaccine;Data;demographics;empowerment;Enrollment;Epidemic;Equity;experience;Feedback;Florida;Fostering;Funding;Future;Health;Health system;HIV;HIV Infections;HIV-infected adolescents;HIV/AIDS;home test;Human immunodeficiency virus test;Immune;improved;Individual;Infrastructure;innovation;Institution;Intervention;Investigational Drugs;Laboratories;Leadership;Link;member;Mental Health;Methods;Modeling;multidisciplinary;novel therapeutics;operation;Participant;patient population;Pharmacy facility;Phase;Prevention;programs;Protocols documentation;Public Health;recruit;Research;Research Infrastructure;Research Personnel;Resources;response;Risk;Services;Sexually Transmitted Diseases;Site;Structure;Substance abuse problem;Surveys;Teenagers;Testing;Therapeutic;Therapeutic Studies;therapy adherence;Training;Translational Research;Universities;Vaccination;vaccine hesitancy;vaccine response;vaccine trial;web page;web site;Work;Youth

PROJECT_TITLE: University of South Florida Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)


PI_NAMEs: DRIVER, BARBARA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adolescent Medicine Trials Network;Agreement;Clinical;Clinical Trials;Collaborations;Communication;community advisory board;Dedications;Development;Devices;Documentation;Dropout;Enrollment;Ensure;experience;Funding;Goals;Good Clinical Practice;HIV-infected adolescents;HIV/AIDS;human subject protection;Infrastructure;Intervention;Intervention Studies;Investigational Drugs;Knowledge;Laboratories;Lead;Leadership;Manuals;Measures;meetings;Methodology;Modification;Monitor;National Institute of Child Health and Human Development;operation;Performance;performance site;Pharmacologic Substance;Policies;Procedures;Program Development;programs;protocol development;Protocols documentation;quality assurance;Quality Control;Recording of previous events;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resources;Risk;Safety;Schedule;Site;Specimen;Structure;symposium;System;Technology;timeline;tool;Training;United States National Institutes of Health;Vendor;Visit;web site;Work

PROJECT_TITLE: Operations and Collaborations Center - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE The Outcomes and Affordability of Observation Status for Children (OASIS) study will characterize the shift in observation stay assignment of pediatric patients, evaluate the impact of omitting observation stay data when calculating the Agency for Healthcare Research and Quality (AHRQ) Pediatric Quality Indicators, and assess Out-of-Pocket costs for pediatric observation stays using large-scale health care administrative data.

PI_NAMEs: RAVAL, MEHUL V. (contact);TIAN, YAO

PROGRAM_OFFICER_NAME: SAGATOV, ROBYN

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Obesity is a major public health problem. We propose to elucidate how the effects of prenatal obesogen exposure are transmitted, leading to a transgenerational predisposition to obesity. The successful completion of this research will make important contributions to understanding epigenetic transgenerational inheritance, how obesity is transmitted down the generations and will provide insights into how obesity can be prevented and the obesity pandemic curtailed.

PI_NAMEs: BLUMBERG, BRUCE  (contact);SHIODA, TOSHIHIRO

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Adipocytes;Adult;adult obesity;Affect;Animal Model;Animals;Automobile Driving;Biological;Biology;bisphenol A;Cell Count;Cell Separation;Chemical Exposure;Chemicals;ChIP-seq;Chromatin;Chromatin Structure Alteration;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Consumption;Data;design;Desire for food;Diet;Dietary Fats;Disease;disease transmission;DNA;DNA Sequence Alteration;DNA-Binding Proteins;Dose;drinking water;Embryo;Endocrine Disruptors;energy balance;Environment;Environmental Exposure;Environmental Risk Factor;environmental stressor;Enzymes;Epigenetic Process;epigenomics;Etiology;Experimental Designs;Experimental Models;experimental study;Exposure to;Fasting;Fat-Restricted Diet;Fatty acid glycerol esters;Future;Future Generations;Gene Expression;Generations;genome analysis;Germ Lines;Goals;Health;Health Care Costs;Hi-C;Higher Order Chromatin Structure;hormone regulation;Human;human model;Hyperglycemia;Hyperinsulinism;Inherited;insight;Insulin Resistance;Insulinase;Intervention;Knockout Mice;Lactation;Life;Link;Literature;Liver;male;Memory;men's group;Messenger RNA;Metabolic Diseases;metabolic phenotype;Metabolism;Modeling;Molecular;mouse model;mRNA Expression;multiple omics;Mus;Non-Insulin-Dependent Diabetes Mellitus;Nuclear Proteins;Nuclear Receptors;Obesity;obesity prevention;obesogen;Onset of illness;Outcome;pandemic disease;Phenocopy;Phenotype;phthalates;Play;Predisposition;Pregnancy;pregnant;prenatal;prevent;Prevention;Productivity;Public Health;Publishing;rapid weight gain;Repression;Reproducibility;Research;Resistance;response;Risk Assessment;Rodent;Role;Satiation;Series;Structure of primordial sex cell;Techniques;Technology;Testing;transgenerational epigenetic inheritance;transmission process;tributyltin

PROJECT_TITLE: Chromatin contacts are germline-transmissable vehicles underlying epigenetic transgenerational inheritance

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Palliative Care;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Sexual and gender minority (SGM) patients with cancer have asked for programs that can 1) improve their quality of life and 2) help their caregivers as well. However, very few programs that serve cancer patients and their caregivers together have included the perspectives of SGM community members. Our project will address this gap by adapting an intervention, called FOCUS, with feedback from the SGM community, and then test the adapted intervention, FOCUS-SGM, to see if it is acceptable for SGM cancer patients and their caregivers.

PI_NAMEs: HASTERT, THERESA ANN;KAMEN, CHARLES STEWART (contact)

PROGRAM_OFFICER_NAME: DEAN, DAVID WORTH

PROJECT_TERMS: acceptability and feasibility;Address;Affect;arm;cancer care;Cancer Control;Cancer Control Research;Cancer Patient;cancer recurrence;Caregivers;caregiving;Chronic stress;cisgender;Clinic;Clinical Trials;Code;Collaborations;Communication;Communities;community engaged research;Community Outreach;community partners;Consultations;coping;design;Diagnosis;Disparity;Effectiveness;Emotional;evidence base;experience;Face;Family;Feedback;Focus Groups;follow up assessment;follow-up;Friends;Future;gender minority community;gender minority group;gender minority health research;Goals;Grant;Health;Healthcare Systems;Heterosexuals;Improve Access;improved;informal caregiver;Intervention;Lesbian Gay Bisexual Transgender;Lesbian Gay Bisexual Transgender Queer;Link;Malignant Neoplasms;Manuals;member;minority patient;minority stress;Modeling;Monitor;mortality;Names;Outcome;Outcome Measure;Patients;Persons;phenomenological models;pilot trial;Population;post intervention;Problem Solving;programs;psychoeducation;psychoeducational intervention;psychological distress;psychosocial;Psychosocial Assessment and Care;Quality of life;Randomized;randomized trial;recruit;Resources;response;Sampling;Self Efficacy;Services;Sexual and Gender Minorities;sexual minority group;sexual relationship;Stigmatization;symptom management;System;Testing;theories;Transcript;Treatment Efficacy;trial planning;Uncertainty;Waiting Lists

PROJECT_TITLE: Adapting the FOCUS Program for Sexual and Gender Minority (SGM) Cancer Patients and Caregivers


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Genetics;Immunotherapy;Prevention;Women's Health Research

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE  By combining the awesome power of mouse genetics, precious clinical samples, and cutting-edge technologies, this multidisciplinary team is poised to illuminate a novel function of T cell-specific BRCA1 in antitumor immunity, immunotherapy, and transcriptional regulation. The proposed work promises to have a far- reaching conceptual and translational impact on the current understanding of BRCA1 tumor suppressor function and development of new cancer prevention options for BRCA1 mutation carriers.

PI_NAMEs: HU, YANFEN ;LI, RONG  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Affect;Age;Attenuated;BRCA1 gene;BRCA1 Mutation;Breast Epithelial Cells;breast tumorigenesis;Cancer Biology;Cancer Etiology;cancer immunotherapy;cancer prevention;cancer risk;CD8-Positive T-Lymphocytes;Cells;Cellular biology;Clinical;cohort;Complement;Coupled;Data;Defect;Development;Dimensions;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;driving force;epithelial repair;Epithelium;experimental study;Foundations;Genetic;Genomic Instability;genomic tools;Germ Lines;Germ-Line Mutation;Heterozygote;Human;Immune;Immune Evasion;Immune system;Immunotherapy;Impairment;Incidence;Knock-out;Knowledge;Label;Laboratory Finding;lifetime risk;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Mass Spectrum Analysis;Mature T-Lymphocyte;Molecular;mouse genetics;multidisciplinary;Mus;mutant;mutant mouse model;mutation carrier;mutational status;neoplasm immunotherapy;Neoplasms;neoplastic cell;novel;Oncogenes;Operative Surgical Procedures;Positioning Attribute;preclinical study;prophylactic;repaired;Research;response;Risk;Risk Reduction;Role;Sampling;Somatic Cell;T-Lymphocyte;Technology;Testing;Time;tool;Transcriptional Regulation;translational impact;tumor;Tumor Immunity;tumor immunology;Tumor Suppressor Proteins;tumorigenesis;virtual;Woman;Work

PROJECT_TITLE: T Cell-Specific BRCA1 Function in Antitumor Immunity and Immunotherapy

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: RICE UNIVERSITY

PHR: PROJECT NARRATIVE In this proposal, we will develop a general platform to specifically deliver epigenetic inhibitors to the bone and demonstrate their utilities for the treatment of skeletal micrometastases of breast cancer. These active bone- targeted epigenetic inhibitors will afford a promising avenue for the treatment and prevention of bone metastases and multi-organ metastases from the bone lesion site.

PI_NAMEs: XIAO, HAN  (contact);ZHANG, XIANG

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Adverse effects;Affinity;Antitumor Response;Binding;Biology;bisphosphonate;bone;Bone Diseases;Bone Metastases Prevention;Bone neoplasms;Brain;breast cancer metastasis;breast cancer progression;Breast Cancer survivor;Breast Cancer therapy;cancer cell;Cancer Cell Growth;cancer therapy;Cell Physiology;Cells;Cessation of life;Clinic;Collaborations;college;Communities;Data;design;Destinations;Diagnosis;Disseminated Malignant Neoplasm;Distant;Engineering;Enhancers;Enzymes;Epigenetic Process;epigenetic therapy;Estrogen receptor positive;Exhibits;Genomics;Goals;Histones;Homing;Homologous Gene;hormone therapy;Human;iliac artery;Immune;Immunosuppression;Impairment;improved;In Vitro;in vivo;inhibitor;Injections;knock-down;Lesion;limb bone;Liver;Lung;Malignant Bone Neoplasm;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Medicine;Metastatic Neoplasm to the Bone;Micrometastasis;Modeling;Modification;Molecular;mouse model;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel therapeutic intervention;Nude Mice;Operative Surgical Procedures;Organ;osteogenic;Osteolytic;Patients;Phenotype;prevent;Primary Neoplasm;Prodrugs;Prognosis;programs;Reporting;Research;Rice;self-renewal;Series;Shapes;Site;skeletal;Skeletal system;Skeleton;small molecule inhibitor;Solid;stem;stem cells;stemness;T cell response;T-Lymphocyte;targeted treatment;Therapeutic;therapeutic target;Time;Tissues;Toxic effect;Transferase;Treatment Efficacy;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Universities;Visceral;Xenograft procedure

PROJECT_TITLE: Modulation of Epigenetic Target in the Bone to Treat Breast Cancer Metastasis


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Depression;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative This work aims to characterize how adolescent brain development supports the maturation of memory-guided decision-making. Adolescence is a period of the lifespan accompanied by heightened risk for maladaptive decision-making, a profile that confers risk for psychopathology, including depression. By identifying how neurodevelopment shapes the ability to use positive memories to guide adaptive decision-making, these findings could have direct implications for understanding why adolescents are at increased risk for depression.

PI_NAMEs: INSEL, CATHERINE  (contact)

PROJECT_TERMS: Acceleration;Adaptive Behaviors;Adolescence;Adolescent;adolescent brain development;Adult;Age;artificial neural network;Award;Behavior;Behavioral;career;Categories;Clinical;cognitive neuroscience;cognitive process;cognitive testing;computational neuroscience;Computer Models;Corpus striatum structure;Data;data de-identification;Data Set;Decision Making;depressive symptoms;Development;Eating;Episodic memory;Event;experience;Failure;Food;Fostering;Foundations;Functional Magnetic Resonance Imaging;Goals;Hippocampus;Individual;Knowledge;Learning;life span;Link;longitudinal design;Machine Learning;maladaptive behavior;Measures;Mediating;Memory;Mental Depression;Mental Health;Methods;Modeling;neural;neural network;neurobiological mechanism;neurodevelopment;neuroimaging;novel;Outcome;Pathway interactions;Phase;Postdoctoral Fellow;predictive modeling;Prefrontal Cortex;Process;Psychopathology;Research;research study;Research Training;Rewards;Risk;risk prediction;Sampling;Sesame - dietary;Shapes;Specific qualifier value;Specificity;Support System;System;Techniques;Testing;Theoretical model;Training;transition to adulthood;translational approach;two-dimensional;Work;Youth

PROJECT_TITLE: Computational and neurodevelopmental mechanisms of memory-guided decision-making


ADMINISTERING_IC: DC

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Mental Health;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: EL PASO

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO

PHR: PROJECT NARRATIVE  Substance use disorders are continuously rising, affecting over 35 million people worldwide in 2020, and appear to be associated with hearing and/or vestibular losses that cause communication barriers and lack of physical independence, respectively. This large-scaled, multi-site project will be the first to systematically examine the implications of substance misuse on both hearing and vestibular function and to determine the factors that increase the risk for hearing and/or vestibular dysfunction in people with substance use disorders. Considering the steady increase in substance misuse since the coronavirus pandemic, an understanding of the effects of substance misuse on the auditory and vestibular systems and associated risk factors will guide otologic and audiological diagnostic practices and facilitate the development of accessible interventions to enhance communication, health, and the well-being of people with substance use disorders.

PI_NAMEs: CHIAO, AMANDA  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Accidents;addiction;Adult;Affect;Afferent Pathways;Age;alcohol misuse;Alcohols;Anxiety;Audiology;Auditory;Auditory Brainstem Responses;Auditory system;Automobile Driving;Awareness;behavior measurement;Biological;biological sex;Biometry;Caring;Case Study;childhood hearing loss;Chronic;Cochlea;Cochlear Hearing Loss;cohort;Communication;Communication Barriers;comorbidity;Complication;Control Groups;coronavirus pandemic;Data;demographics;Development;Diagnosis;Diagnostic;Early identification;Employment;Epidemiology;equilibration disorder;Equilibrium;Equity;Ethnic Origin;fall risk;Frequencies;Future;Goals;Hair Cells;Head;Health;health disparity;Healthcare;Hearing;hearing impairment;hearing loss risk;hearing range;Hearing Tests;human old age (65+);Illicit Drugs;improved;Incidence;Intervention;Ischemia;Knowledge;Labyrinth;Literature;low socioeconomic status;marginalization;Measures;Medicine;Mental Health;Minority;minority communities;Minority Groups;minority health disparity;Minority Status;Modeling;Noise;Not Hispanic or Latino;novel;oculomotor;Opioid;opioid misuse;otoacoustic emission;Otolaryngology;ototoxicity;Outcome;Overdose;Participant;Patients;Pattern;Peripheral;permanent hearing loss;Personal Satisfaction;Persons;Pharmaceutical Preparations;physical conditioning;Physiological;Physiology;Population;Positioning Attribute;prescription opioid;Prevalence;Probability;Quality of life;Questionnaires;Race;Recommendation;Recovery;recruit;Rehabilitation therapy;Reporting;Research;Research Design;Residual state;Risk;Risk Factors;risk prediction;Secondary to;Severities;sex;Sex Differences;Site;social;social factors;Societies;Socioeconomic Status;socioeconomics;speech in noise;Speech Perception;substance misuse;substance use;Substance Use Disorder;Testing;Time;Trauma;Unemployment;Vascularization;Vestibular dysfunction;Vestibular function;Vestibular Hair Cells;Vestibular loss;vestibular pathway;vestibular system;Visual Acuity;Work

PROJECT_TITLE: Characterizing the Effects of Chronic Substance Misuse on Auditory and Vestibular Function


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: NEUROSURGERY

PHR: Project Narrative Recurrent mutations in Isocitrate Dehydrogenase 1 and 2 (IDH1/IDH2) drive several epigenetically dysregulated solid and hematological malignancies, most of which remain incurable. IDH mutant (IDHm) gliomas are a form of malignant brain cancer. IDH gliomas are more common in younger adults, are initially sensitive to chemotherapy and radiation, yet universally result in lethal recurrence following variable periods of remission. These vexing clinical features of IDHm glioma are partially explained by multiple recently described mechanisms through which IDHm tumor cells escape surveillance by the human immune system. Using mouse models and tumor samples derived from human patients, our group has discovered defective signaling in the Retinoic Acid pathway as a major driver of tumor-induced immune escape. Remarkably, clinical regimen containing All-Trans Retinoic Acid and Immune Checkpoint Inhibitors cure aggressive IDHm gliomas in an immunocompetent mouse model. This recent discovery led to a human clinical trial, recently opened at the University of Pennsylvania, to investigating All-Trans Retinoic Acid and Retifanlimab (a PD-1 inhibiting monocloncal antibody) in patients with recurrent IDHm glioma. Despite this promising development, several substantial questions regarding the mechanism of ATRA action remain unanswered. In this proposal, we set out to answer some of those questions by identifying the specific immune cells responsible for the therapeutic activity of All- Trans Retinoic Acid in IDHm gliomas. Equally importantly, we propose a thoroughly designed set of experiments in mouse models to predict response to ATRA and ATRA+Immune Checkpoint blockade, particularly in patients who receive ATRA or ATRA+Immune Checkpoint blockade prior to surgical resection as part of our trial. This proposal leverages recent advances in immune profiling of tumor tissue and circulating blood immune cells to carefully dissect immune cell populations and genetic signatures that are required for response to therapy in IDHm glioma and provide a readout for immunotherapeutic efficacy of ATRA and potentially other immune-directed therapies in IDHm gliomas. If successful, our proposal will contribute several important data points to help advance the discovery of additional immunotherapeutic strategies to substantially extend the lives of patients with IDHm glioma.

PI_NAMEs: AMANKULOR, NDUKA MGBECHINYERE (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Address;Adjuvant;Age;Antibodies;Biological Markers;Blood;Brain;Brain Neoplasms;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;Cessation of life;checkpoint inhibition;Chemotherapy and/or radiation;Clinical;clinical efficacy;Clinical Trials;cohort;Combined Modality Therapy;Data;design;Development;Diffuse;Disease remission;Dose;Epigenetic Process;epigenetic silencing;Evaluation;Excision;Exclusion;exhaustion;Exhibits;experimental study;Future;Gene Expression Profile;gene network;genetic signature;Genetic Transcription;Genotype;Glioma;Goals;Hematologic Neoplasms;Human;human subject;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunocompetent;immunogenic;immunogenicity;Immunologic Markers;Immunologic Monitoring;Immunologic Surveillance;Immunologics;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Infiltration;Inflammatory;Institutional Review Boards;Interferon Type II;Interferons;Isocitrate Dehydrogenase;Knowledge;Lymphocyte;Lymphocyte Function;Lymphocytic Infiltrate;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Mediator;Modality;Modeling;mouse model;Mus;mutant;Mutation;Myelogenous;Myeloid-derived suppressor cells;Natural Killer Cells;Neoadjuvant Therapy;neoplastic cell;Operative Surgical Procedures;Output;Pathway interactions;Patients;PD-1 inhibitors;Pennsylvania;Performance;Phase II Clinical Trials;Population;pre-clinical;predicting response;Prediction of Response to Therapy;programmed cell death protein 1;Recurrence;Regimen;Regulatory T-Lymphocyte;Reporting;Resistance;response;restoration;Retinoids;Sampling;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sleeping Beauty;small molecule;Solid;specific biomarkers;Specificity;Specimen;T cell receptor repertoire sequencing;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte and Natural Killer Cell;Techniques;Testing;Therapeutic;Therapeutically Targetable;Tissues;transcriptome sequencing;treatment response;Tretinoin;tumor;Tumor Biology;tumor eradication;Tumor Immunity;Tumor Tissue;Tumor-Infiltrating Lymphocytes;Universities;Validation;XCL1 gene;young adult

PROJECT_TITLE: Interrogating Mechanisms of Anti-tumor Immunity in Human Subjects and Murine Models of IDH-Mutant Glioma Treated with All-Trans Retinoic Acid and PD-1 Inhibition


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

ORG_DEPT: OPHTHALMOLOGY

PHR: Yale Core Grant for Vision Research Project Narrative The overall objective of the Yale Vision Research Core Program is to provide fundamental and innovative technologies to support and enhance vision research at Yale University. With three key resource/service Core modules, this Program will aid the ongoing research projects of vision research investigators by providing facilities and expertise that cannot be readily supported by individual research grants. This Core Program will enhance scientific interactions between current and future vision researchers at Yale and will facilitate the development of vision research programs for new investigators and for established investigators interested in entering the field of vision research.

PI_NAMEs: DEMB, JONATHAN B (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Appointment;Basic Science;Behavior;Behavioral;Biological Models;Cell Culture Techniques;Cells;cellular imaging;collaborative environment;Computers;Core Grant;Custom;Department chair;Dependovirus;design;Development;DNA;Environment;fabrication;Faculty;Fishes;fly;Fostering;Foundations;Functional Imaging;Funding;Future;Genotype;Histology;Human;Image;Individual;Infrastructure;innovation;innovative technologies;Institution;interest;Investments;Laboratories;Microscope;Minor;Molecular Biology;Mus;Neurosciences;neurotechnology;nonhuman primate;Ophthalmology;Production;programs;Protocols documentation;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Research Project Summaries;Resources;Retina;Services;superior colliculus Corpora quadrigemina;Techniques;Technology;Thalamic structure;Tissues;Training;trend;Universities;Virus;Vision;vision development;Vision research;vision science;Visual Cortex;Visual System

PROJECT_TITLE: Yale Core Grant for Vision Research


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TERMS: Administrator;Advisory Committees;Core Facility;Core Grant;Doctor of Philosophy;Ensure;Equipment;Equity;Evaluation;Faculty;Feedback;flexibility;Funding;Goals;Grant;Individual;Infrastructure;Laboratories;meetings;programs;Records;Reporting;Research Personnel;Research Project Grants;Resources;Running;senior faculty;Services;Structure;Vision;Vision research

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: ZHOU, Z JIMMY (contact)

PROJECT_TITLE: Neurotechnology & Fabrication Core


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences

PI_NAMEs: KIM, IN-JUNG  (contact)

PROJECT_TERMS: adeno-associated viral vector;Area;Cell Differentiation process;Cells;Consultations;Core Grant;Custom;Dependovirus;design;DNA Modification Process;DNA Viruses;Equipment;experience;Gene Delivery;Gene Modified;Genetic;Genetic Techniques;Genetically Modified Animals;Genotype;Histologic;Histological Techniques;immunogenicity;Immunohistochemistry;Knowledge;Laboratories;laboratory experience;Laboratory Personnel;Mediating;Modernization;Molecular;Molecular Biology;Molecular Biology Techniques;Mus;Neurons;Pathogenicity;Persons;Plasmids;Preparation;Production;programs;Research;Research Personnel;Resources;Services;Source;Students;Techniques;tool;Training;transgene delivery;transgene expression;Transgenic Animals;Viral;Viral Vector;Virus;Vision;Vision research

PROJECT_TITLE: Virus Production & Molecular Biology Core