NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease related dementia;animal data;Animal Model;Automobile Driving;Bioinformatics;Biological;Biological Specimen database;Biology;cancer prevention;Collaborations;college;Communication;Communities;Comparative Biology;comparative genomics;Consensus;cost effective;Data;data exchange;data management;Data Set;Databases;Dedications;DNA Repair;Ensure;Epigenetic Process;epigenome;Evaluation;Evaluation Research;Foundations;Funding;Genome;Genomic approach;Genomics;Goals;Information Dissemination;insight;Institution;Joints;Laboratories;Leadership;Longevity;Maintenance;Mass Spectrum Analysis;Mediation;medical schools;Medicine;meetings;Methods;Midwestern United States;model organism;Modernization;Molecular;Monitor;Octodon;organizational structure;Preparation;Program Research Project Grants;programs;Progress Reports;Publications;Reagent;Regulation;Research;Research Activity;Research Personnel;Resolution;Resource Sharing;Resources;Rodent;Somatic Mutation;Specimen;Structure;success;synergism;Techniques;Technology;United States National Institutes of Health;Universities;videoconference;Washington;web site

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PI_NAMEs: SELUANOV, ANDREI  (contact)

PROJECT_TERMS: 5 year old;African;Aging;aging clocks;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Animal Model;animal tissue;Animals;Astrocytes;Balaena;Behavioral;Biocompatible Materials;Biological;Biological Assay;Biological Markers;Blood;Brain;Breeding;Cell Culture Techniques;Cell Line;Cell Separation;Cells;Chiroptera;Collaborations;Collection;comparative genomics;Comparative Study;cost;Data;Databases;Development;Disease susceptibility;DNA;DNA analysis;DNA Damage;Engineering;Ensure;Enzymes;Epigenetic Process;epigenome;experimental study;Fibroblasts;Funding;Gamma Rays;gene therapy;Genes;Goals;HAS2 gene;Health;healthspan;Human;Hyaluronidase;IACUC;Impaired cognition;improved;Individual;induced pluripotent stem cell;inhibitor;Intervention;intervention effect;Knock-in;Knock-out;Knockout Mice;life span;Longevity;Malignant Neoplasms;Mammals;Mass Spectrum Analysis;Measures;Mole Rats;Molecular;Monitor;mouse model;Mus;Mutation;Neurofibrillary Tangles;Octodon;Organism;overexpression;Pathogenesis;Pathologic;programs;Proteomics;Protocols documentation;Quality Control;Repair Complex;Reproducibility of Results;Research Personnel;resilience;Resistance;Resources;RNA;Rodent;Sampling;screening;Senile Plaques;sex;Shrews;single cell sequencing;Solid;South American;Standardization;Stress;tau Proteins;Testing;Time;Tissue Banks;Tissue Harvesting;Tissues;Transgenic Mice

PROJECT_TITLE: Primary Cells, Tissues, and Animals Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-D (J3)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: ZHANG, ZHENGDONG  (contact)

PROJECT_TERMS: age related neurodegeneration;age-related disease;Aging;aging process;aging related;Alzheimer's Disease;Alzheimer's disease model;Animal Model;Animals;ATAC-seq;Balaena;Bioinformatics;Cells;Chiroptera;Collection;Communities;comparative;Comparative Biology;comparative genomics;Comparative Study;Computer software;computerized data processing;Computers;Data;Data Analyses;data integration;data portal;data sharing;data standards;data warehouse;Dedications;design;DNA;epigenome;Freezing;Funding;Genome;genomic data;Genomics;Geographic Locations;Goals;improved;Informatics;Infrastructure;Knowledge;Laboratories;life span;Longevity;Maintenance;Malignant Neoplasms;Mammals;Mediating;Methylation;methylome;methylomics;Modeling;Mole Rats;Molecular;Mutation;novel;Octodon;online resource;Online Systems;Phylogenetic Analysis;Predisposition;Privatization;Process;Program Research Project Grants;programs;Proteomics;Research;Research Personnel;Research Project Grants;Resistance;Resources;Rodent;Role;Services;Speed;synergism;Technology;Tissues;tool;transcriptomics;web site;whole genome;Whole Organism;Work

PROJECT_TITLE: Bioinformatics  and Data Integration Core


PI_NAMEs: GORBUNOVA, VERA  (contact)

PROJECT_TERMS: ADP ribosylation;Affect;Age;aged;Aging;aging biomarker;aging clocks;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;animal tissue;anti aging;Balaena;Cells;Centenarian;Chiroptera;cohort;Collaborations;Collection;combinatorial;comparative genomics;Cytoplasm;Data;derepression;DNA;DNA analysis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Transposable Elements;Double Strand Break Repair;Down-Regulation;Enzymes;epigenetic aging;epigenetic clock;Epigenetic Process;epigenome;Evolution;extend lifespan;Fibroblasts;Funding;gene repair;gene therapy;Genes;Genome;Genome Stability;Genomic Instability;Health;healthspan;histone modification;Histones;Human;improved;Individual;Inflammation;inhibitor;innovation;insight;Intervention;intervention effect;Knock-in;Knock-out;life span;Light;Longevity;Maintenance;Mammals;Mass Spectrum Analysis;Measures;Mediating;metabolomics;Modality;Modification;Mole Rats;mouse model;Mus;Mutation;nanoparticle;Neuronal Differentiation;novel;Nuclear;Octodon;old mice;Onset of illness;Organism;overexpression;Pathway interactions;Positioning Attribute;Post-Translational Protein Processing;Proteins;Proteomics;rate of aging;Reader;Repair Complex;Research Personnel;RNA;RNA-Binding Proteins;Somatic Mutation;Testing;Therapeutic;transcriptomics;Variant

PROJECT_TITLE: Mechanisms of epigenome stability in long-lived species.


PROJECT_TERMS: 5 year old;Acceleration;Administrative Supplement;Age;age-related disease;aged;Aging;aging biomarker;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Amino Acid Sequence;Amyloid beta-Protein;amyloid formation;animal data;Animal Model;Animals;Astrocytes;Atlases;behavior test;Biological Markers;Brain;Brain Pathology;brain tissue;Breeding;Cells;Cognitive;Collaborations;Communities;comparative;Comparative Biology;comparative genomics;Data;data integration;Data Set;Degenerative polyarthritis;Deposition;Development;Disease;Disease Progression;Disease Resistance;Disease susceptibility;DNA Damage;DNA Repair;DNA Sequence Alteration;effective therapy;Enzymes;epigenetic clock;epigenome;Etiology;extend lifespan;functional decline;Funding;Genes;Genome;Goals;HAS2 gene;healthspan;Hematopoietic System;Human;human disease;Hyaluronan;Hyaluronic Acid;Impaired cognition;Induced Neurons;Inflammation;Inflammatory Response;insight;Lead;life span;Longevity;Mass Spectrum Analysis;Measures;Medical;Methionine;methionine sulfoxide reductase;Modeling;Mole Rats;Molecular;Molecular Weight;mouse model;Mus;Mutation;Natural Resistance;Nerve Degeneration;novel;novel strategies;Octodon;Octodon degus;oxidation;Oxidative Stress;Pathway interactions;Peripheral;pharmacologic;Predisposition;protective pathway;protein aggregation;Proteins;Proteome;Proteomics;Protocols documentation;rate of aging;Research;resilience;Resistance;Resources;Rodent;Role;single-cell RNA sequencing;South American;Testing;Thymus Gland;Tissues;trait;transcriptome;transcriptomics;Transgenes;Universities

PROJECT_TITLE: Novel animal models of brain longevity and Alzheimer's disease


PI_NAMEs: VIJG, JAN  (contact)

PROJECT_TERMS: Age;age related;age-related disease;Aging;aging biomarker;aging clocks;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Animal Model;Animals;Automobile Driving;Balaena;Brain;Candidate Disease Gene;Cells;comparative genomics;Core Assembly;Detection;Development;Disease;Disparate;DNA;DNA Methylation;DNA methylation profiling;DNA Repair;DNA Sequence Alteration;drivers of aging;Epigenetic Process;epigenome;Fibroblasts;Frequencies;Gamma Rays;Genome;genome sequencing;genome-wide;Genomics;Induced Mutation;Intervention;irradiation;L1 Elements;Life;life span;Longevity;longevity gene;Low Dose Radiation;Maintenance;Mammals;Maps;Measures;Methods;Methylation;methylome;Mole Rats;molecular clock;mouse model;Mutagens;Mutation;Normal Cell;Normal tissue morphology;novel strategies;Octodon;Octodon degus;overexpression;Play;Radiation;Radiation exposure;radiation response;Repetitive Sequence;resilience;Rodent;Rodent Model;Role;single molecule;Somatic Mutation;Stress;Technology;Testing;transcriptome;transcriptome sequencing;Variant

PROJECT_TITLE: Genome and epigenome stability in long- and short-lived animal species


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PI_NAMEs: GLADYSHEV, VADIM N. (contact)

PROJECT_TERMS: Address;Adult;Aging;aging biomarker;aging clocks;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Animal Model;Animals;Balaena;Benchmarking;Biological;biological age;Biological Markers;Brain;Cardiac Myocytes;Cell Differentiation process;Cell Reprogramming;cell type;Cells;Chromosomes;Collaborations;comparative;comparative genomics;Data;Data Set;Development;Disease;Embryo;epigenetic clock;Epigenetic Process;epigenome;Fibroblasts;Genome;Goals;healthspan;Human;induced pluripotent stem cell;insight;Intervention;intervention effect;Life;life span;Longevity;Mammals;mature animal;metabolome;Modeling;Modification;Mole Rats;Molecular;Molecular Profiling;mouse model;multiple omics;Mus;Mutation;Nature;Neurons;Octodon;Organoids;Pattern;Phase;predictive marker;Predisposition;programs;rate of aging;Rattus;Reporting;Rodent;Shrews;Stimulator of Interferon Genes;System;Testing;Time;Tissues;tool;transcriptome;transcriptomics;Whales

PROJECT_TITLE: Multi-omics biomarkers and molecular features of aging, longevity and Alzheimer's disease


ADMINISTERING_IC: HG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: The rapidly developing field of precision and genomic medicine offers enormous opportunities to transform research and clinical practice. This postdoctoral training program brings together three outstanding components to build a world-class training program in genomic medicine: 1) an internationally-recognized faculty of experienced mentors with expertise in precision and genomic medicine, 2) outstanding institutional resources bridging clinical, genomic, and data sciences, and 3) deep engagement with cutting edge, collaborative initiatives at the regional, national, and international levels to provide rich training experiences. Our goal is to provide rigorous, multidisciplinary training for a new generation of scientific leaders who can drive progress in the field.

PI_NAMEs: REHM, HEIDI L;SMOLLER, JORDAN W (contact)

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TERMS: Genomic medicine;precision medicine;Training Programs

PROJECT_TITLE: Mass General Brigham Training Program in Precision and Genomic Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-M (J1)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: The main goal of the Structural Biology and Molecular Biophysics Training Program at the University of Pennsylvania is to train a cadre of superlative students and put them on the trajectory to achieve success and leadership roles at the highest levels of academic and industrial science in this core area of biomedical research. We will leverage the immense resources, 45 outstanding faculty trainers, and talented graduate students of UPenn to accomplish this goal. The program will do so with a premium put on training in the technically challenging aspects of experimentation in this area of biomedicine, scientific thinking, integration of structural biology and molecular biophysics research within the broader biomedical scientific community, presentation skills, career-focused exploration, and achieving success through promoting and rejoicing diversity and inclusion in the scientific workplace and community.

PI_NAMEs: BLACK, BEN E. (contact);RHOADES, ELIZABETH

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: Structural biology and molecular biophysics training program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative In the United States, 19 to 25 million children make more than 29 million emergency department (ED) visits each year. The Pediatric Emergency Medicine Training Program offers unique training in biomedical informatics and genomics for the next generation of leaders in pediatric acute care research. Thus, when ill or injured children arrive at the ED, they can receive the best evidence-based care, with the most effective diagnostics and treatments possible.

PI_NAMEs: MANDL, KENNETH D. (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Emergency Medicine;pediatric emergency;Research Training

PROJECT_TITLE: Research Training in Pediatric Emergency Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-R (90)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Complementary and Integrative Health;Hematology;Prevention

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE Although clinical guidelines recommend that sexual health be routinely discussed clinically for all patients with a cancer diagnosis, a lack of training for oncologists in how to discuss sexual health effectively with patients serves as perhaps the single most critical impediment to clinical communication about this topic. The objectives of the proposed project are to (1) develop a novel, virtual group-based course to train fellows in hematology-oncology in effective clinical communication about sexual health (SHIFT; Sexual Health Integrative Fellowship Training), and (2) evaluate the acceptability and impact of the course across two fellowship programs. This project has public health relevance because enhancing hematology-oncology fellows’ communication skills about sexual health with their patients could enhance delivery of cancer care and improve outcomes for patients’ sexual health and overall quality of life.

PI_NAMEs: REESE, JENNIFER BARSKY (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;advanced disease;Aftercare;Behavior Therapy;Belief;biopsychosocial;Body Image;cancer care;cancer diagnosis;Cancer Patient;cancer site;care outcomes;Caring;Clinical;clinical care;Clinical Practice Patterns;cohort;Communication;curriculum development;Dana-Farber Cancer Institute;design;Development;Diagnosis;Distress;Education;Emotional;Erectile dysfunction;Evidence based intervention;Expectancy;experience;Faculty;Failure;Fatigue;Feedback;Fellowship;Fellowship Program;Foundations;Fox Chase Cancer Center;Gender;gender minority;Goals;Guidelines;Health;health communication;Healthcare;Hematology;improved;improved outcome;Individual;innovation;Instruction;Integrative Medicine;Intervention;Intervention Studies;Knowledge;Malignant Neoplasms;method development;Methods;minority patient;Modeling;Nature;neglect;novel;Oncologist;Oncology;Outcome;Pain;Patient Compliance;patient population;patient subsets;patient-clinician communication;Patient-Focused Outcomes;Patients;Pattern;Personal Satisfaction;preference;Process;public health relevance;Qualitative Research;Quality of life;Readiness;Recommendation;Reporting;Research;Research Project Grants;Self Efficacy;Series;sex;Sex Behavior;Sexual and Gender Minorities;Sexual Health;sexual minority;Sexual Partners;Site;skill acquisition;skills;skills training;social cognitive theory;Surveys;Testing;theories;Time;Training;Training and Education;Veins;virtual;virtual group;women patients;Work

PROJECT_TITLE: Addressing the Training Gap in Oncology on Sexual Health: Development of the Sexual Health Integrative Fellowship Training (SHIFT) Course for Hematology-Oncology Fellows

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: CAMDEN

ORG_DEPT: BIOLOGY

ORG_NAME: RUTGERS THE STATE UNIV OF NJ CAMDEN

ORG_STATE: NJ

PHR: The mission for the U-RISE at Rutgers University - Camden program is to increase the number of well-prepared students from underrepresented groups for highly selective Ph.D. or combined M.D.-Ph.D.-level training in the biomedical sciences. The U-RISE at Rutgers University - Camden program will achieve this mission by expanding and supporting the established curricular research training curriculum.

PI_NAMEs: FRIED, NATHAN THOMAS;LEE, KWANGWON  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Academic achievement;Academic support;Address;Biological Sciences;Biology;Biomedical Research;bridge program;career;career awareness;CCL7 gene;cohort;Collaborations;Communities;community building;Degree program;design;Development;Doctor of Medicine;Doctor of Philosophy;Educational workshop;Eligibility Determination;Fostering;Goals;Grant;Growth;handbook;Institution;interest;leadership development;Location;Mentors;Mentorship;Outcome;Population;programs;recruit;Research;Research Training;resilience;responsible research conduct;Safety;skill acquisition;skills;STEM field;STEM student;Students;success;Talents;Training;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities

PROJECT_TITLE: U-RISE at Rutgers University - Camden

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The Washington University T32 training grant “Multidisciplinary Training in Alzheimer and Related Dementias” (ADRD-T32) is designed to prepare the next generation of researchers in Alzheimer disease and related dementias. The program provides training in collaborative, multidisciplinary research for predoctoral and postdoctoral trainees from a variety of disciplines, emphasizing translational research and utilization of large scale NIH-supported data sets.

PI_NAMEs: MCDADE, ERIC MARTIN;SNIDER, BARBARA JOY (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Alzheimer's disease related dementia;multidisciplinary;Training

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (J2)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: NASHVILLE

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: Project Narrative Historically Black Colleges and Universities (HBCUs) remain critically essential in training a significant number of diverse Science, Technology, Engineering and Math (STEM) graduates. The effects of COVID-19, and other emerging public health threats continue to have an unrelenting impact on all aspects of society and will require continued development of new therapeutics to help prevent deaths, which requires a diverse representation of educators and researchers, particularly from HBCUs, to make innovative contributions in this area. The proposed HBCU/MSI Mentored Research Program in the Structural Biology of Human Pathogens at Meharry Medical College will provide a 10-week intensive, hands-on mentored research experience for students (community college, undergraduate, medical) to gain the skill of solving protein structures using X-ray crystallography.

PI_NAMEs: DAVIS, JAMAINE S (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: 3-Dimensional;Academia;Academic Medical Centers;Area;Authorship;Biomedical Research;Biophysics;Black race;career;career development;Cessation of life;combat;Communicable Diseases;community college;Computer software;course development;COVID-19;COVID-19 impact;COVID-19 pandemic;Crystallization;Data;Data Collection;data structure;design;Development;Development Plans;Disease;Doctor of Medicine;Doctor of Philosophy;drug development;Economic Burden;Education;Educational process of instructing;Educational workshop;Ethnic Population;Evaluation Research;experience;Faculty;Funding;future outbreak;Genomic Centers for Infectious Diseases;Global Awareness;Goals;hands on research;Historically Black Colleges and Universities;human pathogen;improved;Individual;Industry;Infectious Agent;innovation;interest;Journals;lectures;Medical;medical schools;Medicine;member;Mentors;Mentorship;Microbiology;Mission;National Institute of Allergy and Infectious Disease;next generation;novel;novel therapeutics;Oral;Participant;Play;posters;prevent;Production;Productivity;Program Evaluation;programs;Protein Biochemistry;protein structure;protein structure prediction;Proteins;Protocols documentation;Public Health;Publications;Publishing;racial population;recruit;Research;Research Personnel;Research Project Grants;Research Training;Roentgen Rays;Schools;Science;Science, Technology, Engineering and Mathematics;Scientist;skills;Societies;Structural Biochemistry;Structural Biologist;structural biology;structural genomics;Structure;Students;summer program;summer research;symposium;Therapeutic;three dimensional structure;Training;Training and Education;Training Programs;undergraduate student;Underrepresented Minority;underrepresented minority student;underserved community;virtual;virtual platform;Work;X-Ray Crystallography

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 TC-D (J1)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: PITTSBURGH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE Training a strong cadre of graduate students and postdoctoral fellows in vision research will guarantee a new generation of scientists who will study the visual system in health and disease. The IVS training program provides a multidisciplinary and rigorous understanding of the visual system, from eye to brain and from basic and translational perspectives, and graduates will forge novel approaches in advancing vision science and developing intervention and therapeutic frameworks.

PI_NAMEs: BEHRMANN, MARLENE ;KINCHINGTON, PAUL R. (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Training Programs;vision science

PROJECT_TITLE: Interdisciplinary Visual Sciences (IVS) Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (05)]


ORG_CITY: STONY BROOK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE Disseminated candidiasis, the 3rd most common hospital-acquired infection, results in kidney damage. Interleukin-17 plays an unexpected kidney protective role in disseminated candidiasis. The objective of this project is to understand in detail the mechanisms of IL-17-mediated renal protection with a long-term goal of using this knowledge for therapeutic benefits.

PI_NAMEs: BISWAS, PARTHA SARATHI (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: aggressive therapy;anti-fungal agents;Apoptosis;Apoptotic;autoinflammatory diseases;Autopsy;Basic Science;Candida albicans;Candidiasis;Caspase;Cell Communication;Cell Line;cell type;Cells;Cessation of life;chemokine;chromatin immunoprecipitation;Complex;conditional knockout;cytokine;Data;Death Rate;Development;diagnostic tool;Disseminated candidiasis;Distal;drug resistance development;Early Diagnosis;effective therapy;Electron Transport;Enzymes;Epithelial Cells;Event;Exhibits;Family;Functional disorder;Fungal Drug Resistance;fungus;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Grant;Human;Hyphae;IL17 gene;Immune response;Immunity;in vivo;Infection;Inflammatory;inhibitor;insight;Invaded;Iron-Sulfur Proteins;Kidney;Knockout Mice;Knowledge;Link;lymphoid organ;Mediating;member;Membrane Potentials;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Morbidity - disease rate;mortality;Mus;Mutation Analysis;Mycoses;Nicotinamide adenine dinucleotide;Nosocomial Infections;novel;Organ;Oxidative Phosphorylation;Oxidoreductase;pathogenic fungus;Pathway interactions;Patients;pharmacologic;Phenotype;Play;prevent;Production;promoter;Psoriasis;Receptor Signaling;Regulation;renal damage;Research;Respiratory Chain;RNA Interference;Role;Scheme;Sepsis;Signal Pathway;Signal Transduction;Systemic infection;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissues;Toxic effect;Tubular formation;Ubiquinone;Vaccines

PROJECT_TITLE: IL-17-epithelial cells interaction in organ damaging infections

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative This post-doctoral research fellowship program trains individuals for careers in academic medicine to conduct scientific research in the field of complementary, integrative, and whole person health. This is an important and growing area of health that requires ongoing research to better understand mechanisms, efficacy, cost effectiveness, translation and implementation into our modern healthcare system.

PI_NAMEs: YEH, GLORIA Y (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Complementary Medicine;Integrative Medicine;Research Training

PROJECT_TITLE: Research Training in Complementary and Integrative Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (03)]


NIH_SPENDING_CATS: Aging

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The Duke University/University of North Carolina (UNC) Advancing Diversity in Aging Research Program is an innovative research training program designed to offer training and support to undergraduate students from diverse backgrounds at Duke University and UNC-Chapel Hill to pursue careers in aging and resilience research. By combining the unique strengths of both institutions, this program will sow the seeds for the development of a cadre of diverse scientists with expertise in aging research and promote a strong community of researchers who are equipped to optimize reserve and resilience among older adults.

PI_NAMEs: BAKER, TAMARA A;MARQUINE, MARIA  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Admission activity;African American population;Aging;Black Populations;career;Career Choice;career development;Clinical;cohesion;Communities;community engagement;community involvement;Creativeness;design;Development;Development Plans;education research;Educational Curriculum;Enrollment;Environment;ethnic minority population;Evaluation;experience;Exposure to;Faculty;Feeling;Fostering;Funding;Goals;graduate school;Grant;Group Meetings;health disparity;Hispanic Populations;Hour;Human Development;improved;Individual;Infrastructure;innovation;Institution;interest;Knowledge;Latino Population;life span;Lived experience;meetings;Mentors;Middle Eastern;multidisciplinary;North African;North Carolina;Not Hispanic or Latino;older adult;Outcome;Outcome Measure;peer;Peer Group;Persons;Population;programs;public trust;racial minority population;Research;Research Activity;Research Personnel;Research Training;resilience;resilience research;Resources;Science;Scientist;Senior Scientist;skills;social disparities;Students;success;Talents;Thinking;tool;Training;Training Programs;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities

PROJECT_TITLE: Duke/UNC ADAR Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (J2)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE Roswell Park Comprehensive Cancer Center is one of only a small number of freestanding, NCI-designated, comprehensive cancer centers, and the only comprehensive center in New York State (NYS) outside of Manhattan. Roswell Park has a rich history of leadership in basic discovery, translational, clinical and population- based science in cancer research. In recent years Roswell Park has pushed the boundaries of excellence in cancer research and has experienced exponential growth in faculty recruitment, programmatic and scientific excellence, a robust clinical trial portfolio and accrual to investigator-initiated trials, population cancer science development and a broader footprint in the WNY catchment area and community with a focus on diversity, equity and inclusion. We propose here to be a leader in the development of innovative approaches in cancer research to improve the quality of care for our patients in our catchment area and beyond, to enhance collaborative efforts between scientists and physicians toward a more effective translation of our discoveries into paradigm changing patient practices and interventions and policies, to train and develop the next generation of investigators through innovative oncology-focused programs, to focus on the needs of our catchment area of WNY relevant to our cancer burden and related disparities through research and outreach using effective strategies for education, prevention, treatment and survivorship and to cultivate, value and support diversity, equity, inclusion and belonging across our cancer center employees, scientists, physicians, nurses and healthcare staff, students and trainees and leadership toward a more productive and diverse workplace and to serve our community more effectively. Roswell Park continues to play a primary role in discovery and innovation that enable us to deliver the best cancer care to our patients in New York State, around the country and around the world.

PI_NAMEs: JOHNSON, CANDACE S (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Address;Alaska Native;anti-cancer research;Area;Award;Basic Science;Black American;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer education;cancer prevention;Cancer Science;cancer therapy;Care given by nurses;Catchment Area;Clinic;Clinical;Clinical Sciences;Clinical Trials;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Country;Development;Diagnosis;Discipline;Disparity;diversity and equity;Education;Employee;Equity;equity, diversity, and inclusion;experience;Faculty;Faculty Recruitment;Funding;Grant;grasp;Growth;health equity promotion;Healthcare;high risk;Hispanic Americans;Human Resources;Humanities;improved;Infrastructure;innovation;Institution;Intervention;investigator-initiated trial;Leadership;Malignant Neoplasms;member;Mission;mortality;National Cancer Institute;Native Americans;New York;next generation;Oncology;outreach;Paper;Patients;peer;Peer Review;Physicians;Play;Policies;Population;population based;Population Sciences;Positioning Attribute;Prevention;Prevention education;Productivity;programs;Publications;Quality of Care;Recording of previous events;recruit;Request for Applications;Research;Research Personnel;Resource Sharing;Resources;Role;Science;Scientific Advances and Accomplishments;Scientist;Screening for cancer;Students;survivorship;Tobacco use;Training;Training and Education;translational potential;Translations;treatment trial;Underrepresented Minority;underserved community;Workplace

PROJECT_TITLE: Roswell Park Cancer Center Support Grant

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: HENRY, DALE  (contact)

PROJECT_TERMS: Acceleration;Administrator;anti-cancer research;Applications Grants;Businesses;Cancer Center;Cancer Center Support Grant;Cell Therapy;Communication;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Custom;Data;Development;Documentation;Education;Electronics;Ensure;Equipment;equity, diversity, and inclusion;Evaluation;experience;Faculty;Faculty Recruitment;Flowers;Fostering;Funding;Future;Genetic;Genomics;Goals;grasp;Guidelines;healing;Humanities;implicit bias;Information Technology;Infrastructure;Institution;instrumentation;Investments;Knowledge;Laboratories;Leadership;leadership development;Malignant Neoplasms;Marketing;meetings;member;Mission;Modeling;Monitor;Newsletter;Occupational activity of managing finances;Organization and Administration;Patient-Centered Care;Periodicals;personalized approach;Philanthropic Fund;Pilot Projects;Play;Procedures;Process;Program Development;programs;Publications;recruit;Research;Research Support;Resource Sharing;Resources;Role;Science;Services;Standardization;Strategic Planning;success;Support System;System;Teacher Professional Development;Training;Training and Education;Update;web page

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Pediatric

PI_NAMEs: SESHADRI, MUKUND  (contact)

PROJECT_TERMS: Admission activity;anti-cancer research;Award;Cancer Center;Cancer Center Support Grant;cancer education;cancer epidemiology;Cancer Science;Career Choice;career development;career life balance;Career Mobility;Catchment Area;Cities;Collaborations;college;Communication;community engagement;Community Outreach;Databases;demographics;Dental;design;Discipline of Nursing;Diverse Workforce;Doctor of Philosophy;Education;education research;Educational workshop;Enrollment;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;Event;experience;Faculty;faculty community;faculty mentor;Feedback;Fellowship Program;Future;graduate medical education;Grant;high school;high school program;High School Student;human old age (65+);improved;Institution;K-12 student;Knowledge;Leadership;Malignant Neoplasms;Mandatory Programs;Measures;Medical;Medical Students;Medicine;Mentored Clinical Scientist Development Program;Mentors;minority trainee;Mission;National Heart, Lung, and Blood Institute;Native American Research Center for Health;next generation;Nurses;Oncology;oncology program;operation;Outcome;outreach;Participant;Performance;post-doctoral training;Postdoctoral Fellow;Productivity;Program Development;programs;recruit;Research;Research Support;Residencies;resilience;Resource Sharing;Scholars Program;Schools;Science;Series;Students;summer internship;summer research;Surgical Oncology;Systems Integration;Teacher Professional Development;Training;Training and Education;Training Programs;Travel;trend;tumor immunology;Underrepresented Minority;Universities;university student;Writing;Youth

PROJECT_TITLE: Cancer Research Training and Education Coordination


PI_NAMEs: RODRIGUEZ, ELISA MARIE (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;Benchmarking;Biomedical Research;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Survivor;care delivery;career development;Caregivers;Catchment Area;Climate;Collaborations;Communication;Communities;community advisory board;community collaboration;community engagement;Community Outreach;Data;Development;diversity and equity;diversity and inclusion;Doctor of Philosophy;Education;Educational Status;Educational workshop;Employee Engagement;Ensure;Environment;equity, diversity, and inclusion;Evaluation;Faculty;Faculty Recruitment;Feedback;Goals;improved;Individual;Infrastructure;insight;Institution;Leadership;Logic;meetings;member;Mentors;mid-career faculty;Minority;Modeling;Monitor;operation;Organizational Change;outreach;Pathway interactions;Patients;Population;Population Heterogeneity;Population Sciences;Process;programs;Published Comment;recruit;Research;Resource Allocation;Role;Strategic Planning;structural determinants;Students;Surveys;theories;Time;tool;Training;Training and Education;Training and Infrastructure;unconscious bias;Underrepresented Populations;Woman;Work;Workforce Development;working group

PROJECT_TITLE: Plan to Enhance Diversity


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: REPASKY, ELIZABETH A (contact)

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;adrenergic stress;Affect;Aging;anti-tumor immune response;Anxiety;Area;Award;Back;base;Basic Science;bench to bedside;biological adaptation to stress;Biological Markers;Biology;biomarker identification;Biophysics;Cancer Burden;cancer cell;Cancer Center Support Grant;cancer health disparity;Cancer Patient;cancer therapy;Catchment Area;Chronic stress;Clinical;clinical application;Clinical Research;Clinical Trials;clinically relevant;clinically significant;Collaborations;Communities;Comprehensive Cancer Center;Crime;cytotoxic;Data;Development;Disease;Disparity;disparity reduction;Doctor of Philosophy;Ecosystem;Education;Epigenetic Process;Evaluation;experience;Faculty;Financial Hardship;Funding;Future;Goals;Grant;Immunosuppression;Immunotherapy;improved;improved outcome;Individual;Inflammation;Institution;Intervention Trial;Knowledge;Laboratory Research;Learning;Link;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;member;Metabolic stress;Mission;modifiable risk;Molecular;National Comprehensive Cancer Network;Neighborhoods;neoplastic cell;Nerve;Neuroimmune;new therapeutic target;next generation;novel therapeutic intervention;novel therapeutics;Organism;Outcome;Pathway interactions;Patient-Centered Care;Patient-Focused Outcomes;Patients;Peer Review;Peer Review Grants;Population;Pre-Clinical Model;programs;Psychological Stress;Publications;PUVA Photochemotherapy;Quality of life;racial discrimination;Radiation;Radiation therapy;Regimen;Reporting;Research;Research Personnel;Resource Sharing;Risk Factors;Role;rural patients;Science;Scientist;Series;Signal Pathway;Signal Transduction;social health determinants;social stressor;Source;Strategic Planning;Stress;Survivors;Therapeutic Intervention;therapy outcome;Time;Training;Travel;treatment response;tumor;Tumor Immunity;tumor microenvironment;tumor progression;UV induced;Work

PROJECT_TITLE: Cancer Stress Biology


NIH_SPENDING_CATS: Biotechnology;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: TANG, DEAN G. (contact)

PROJECT_TERMS: Address;Androgen Antagonists;anti-cancer research;anti-cancer therapeutic;Area;Basic Science;Big Data;Breast;cancer cell;Cancer Center;Cancer Center Support Grant;cancer health disparity;cancer heterogeneity;cancer stem cell;Catchment Area;Clinical;clinical translation;Clinical Trials;Collaborations;Colon;Communities;community engagement;Community Outreach;Conduct Clinical Trials;Data Analyses;design;Developmental Therapeutics Program;drug development;Drug Targeting;Education;Ensure;epigenome;Etiology;Faculty;faculty mentor;Fostering;Funding;Funding Mechanisms;Goals;Graduate Education;Grant;health disparity;Home;Immune;Immune checkpoint inhibitor;innovation;Institution;Investigational Therapies;Investments;Journals;Leadership;Lung;Malignant Neoplasms;member;Mentors;Mission;Molecular;new therapeutic target;next generation;novel;novel anticancer drug;novel therapeutic intervention;novel therapeutics;Peer Review;Pharmaceutical Preparations;Postdoctoral Fellow;Productivity;Program Development;Program Reviews;programs;Prostate;proteostasis;Publications;recruit;Reduce health disparities;refractory cancer;Research;Research Personnel;Resistance;resistance mechanism;Resource Sharing;Science;Scientist;Series;small molecule inhibitor;stem cells;Strategic Planning;Systems Biology;targeted agent;Therapeutic;therapeutic development;therapy resistant;Training;Training and Education;transcriptome;Translating;Translational Research;translational study;treatment strategy;tumor-immune system interactions;Tyrosine Kinase Inhibitor;Work

PROJECT_TITLE: Developmental Therapeutics


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health;Women's Health Research

PI_NAMEs: AMBROSONE, CHRISTINE B. (contact)

PROJECT_TERMS: Address;African American population;Ancillary Study;anti-cancer research;Area;biobank;Black race;black women;Breast Cancer Patient;Breast Cancer Risk Factor;Cancer Center Support Grant;cancer diagnosis;cancer education;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;cancer therapy;career development;Catchment Area;Central obesity;chemotherapy;Cigarette;Cigarette Smoker;Collaborations;Communities;community advisory board;community engagement;Community Outreach;Data;data repository;Disease;Elements;epidemiology study;equity, diversity, and inclusion;Evaluation;exhaust;experience;Exposure to;Feedback;Fostering;Funding;Future;Genomics Shared Resource;Goals;Grant;grasp;Guidelines;Humanities;Immunotherapy;improved;Individual;insight;Institution;Intervention;Journals;Leadership;Malignant Neoplasms;Mammary Neoplasms;meetings;member;Menthol;Mentorship;Mission;modifiable risk;Molecular;Morbidity - disease rate;mortality;National Comprehensive Cancer Network;Needs Assessment;Outcome;Pathogenicity;Patients;Peer Review;Persons;Phenotype;Physical activity;Policies;Population Sciences;prevent;Prevention education;Primary Prevention;Process;Productivity;Program Development;programs;Publications;Publishing;Quality of life;recruit;Research;Research Personnel;Resource Sharing;Risk;Risk Factors;risk prediction model;Risk Reduction;Science;Shapes;shift work;smoking cessation;Southwest Oncology Group;success;survival outcome;survivorship;Susceptibility Gene;Teacher Professional Development;Tobacco Use Cessation;Tobacco-Related Carcinoma;Training;Training and Education;Treatment outcome;Tumor-Infiltrating Lymphocytes;Underrepresented Populations;vaping;Variant;Vitamins;White Women;Work

PROJECT_TITLE: Population Sciences


PI_NAMEs: ABRAMS, SCOTT I. (contact)

PROJECT_TERMS: Accounting;Active Immunotherapy;anti-cancer research;anti-tumor immune response;Automobile Driving;Award;base;Basic Science;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer immunotherapy;Cancer Patient;cancer type;career;Catchment Area;Cell Therapy;Cellular immunotherapy;Chicago;chimeric antigen receptor T cells;Clinic;Clinical;clinical application;Clinical Research;clinical trial enrollment;Clinical Trials;Collaborations;Communities;community collaboration;community engagement;Community Outreach;Complex;Comprehensive Cancer Center;Dedications;Development;Dysmyelopoietic Syndromes;Education;Encapsulated;Enrollment;Ensure;Environment;Environmental Risk Factor;Faculty;Fostering;Funding;Funding Opportunities;Goals;Grant;grasp;Growth;Health;Hematologic Neoplasms;Human;Humanities;Immune system;Immunologic Markers;Immunology;Immunooncology;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;in vivo imaging;Incidence;Infrastructure;innovation;Innovative Therapy;Institution;Intervention;investigator-initiated trial;Journals;Lead;Leadership;Longevity;Lymphoid;Malignant neoplasm of ovary;Malignant Neoplasms;member;Mentors;Mission;Molecular Profiling;Myelogenous;neoplasm immunotherapy;neoplastic;next generation;novel;Paper;Patient Care;patient population;Patients;Peer Review;Physicians;Positioning Attribute;pre-clinical;Pre-Clinical Model;prevent;Process;Productivity;programs;Public Health;Publications;Qualifying;Quality of life;Recording of previous events;recruit;Research;Research Support;resistance mechanism;Resource Sharing;response;Risk;Role;safety assessment;Science;Scientist;small cell lung carcinoma;Solid;stem;Strategic Planning;Strategic vision;Targeted Research;Testing;Therapeutic;therapeutic target;therapy resistant;Therapy trial;Training;Training and Education;Translating;translational pipeline;Translational Research;treatment trial;Tumor Escape;Tumor Immunity;tumor immunology;Underrepresented Minority;Universities;Work

PROJECT_TITLE: Tumor Immunology and Immunotherapy


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Social Determinants of Health

PI_NAMEs: BOUCHARD, ELIZABETH  (contact)

PROJECT_TERMS: Advocate;anti-cancer research;Appalachian Region;Area;Automobile Driving;Awareness;black women;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;cancer risk;Catchment Area;Clinical Trials;Colorectal Cancer;Communication;Communities;community academic partnership;community advisory board;community engaged research;community engagement;community engagement process;community organizations;Community Outreach;community partners;Comprehensive Cancer Center;County;Data;data resource;Dedications;design;Diagnosis;Disparity;Doctor of Philosophy;education resources;Educational Materials;Equity;evidence base;Evidence based intervention;Federally Qualified Health Center;Fostering;Funding;Funding Mechanisms;Future;Geography;Goals;Government;Growth;Health;health assessment;health disparity;health equity promotion;high risk;improved;Infrastructure;innovation;Intervention;Lead;Leadership;Logic;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;member;Mission;Modeling;Monitor;mortality;New York;nutrition;Outcome;Patients;Physical activity;Pilot Projects;Policies;Population;population health;prevent;Process;programs;Reporting;Research;Research Activity;Research Project Grants;Resources;rural area;Science;Scientist;Screening for cancer;social determinants;social health determinants;Source;Strategic Planning;surveillance data;Tobacco use;underserved community;urban area;Vision;Work

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy

PROJECT_TERMS: Advisory Committees;Aging;Animals;authority;Award;Biological Assay;Biology;Budgets;Cancer Center;Cancer Center Support Grant;cancer research center director;Catchment Area;Clinical Sciences;Collaborations;Community Outreach;Comprehensive Cancer Center;Computer software;CRISPR/Cas technology;Decision Making;Dedications;Development;Developmental Therapeutics Program;Ensure;equity, diversity, and inclusion;Faculty;Faculty Recruitment;faculty support;flexibility;Foundations;Fund Raising;Funding;Future;gene editing technology;Goals;Grant;high reward;high risk;human subject;Immunotherapy;Individual;Infrastructure;innovation;Institution;Investments;Laboratories;Leadership;Malignant Neoplasms;Measures;Mediating;member;metabolomics;Monitor;Mus;neoplasm immunotherapy;novel therapeutics;Peer Review;personalized medicine;Philanthropic Fund;Pilot Projects;Population Sciences;precision medicine;Process;programs;Protocols documentation;Publications;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Review Committee;Risk Taking;Science;service utilization;Services;Standardization;Strategic Planning;Stress;success;System;Techniques;Therapeutic;Translational Research;tumor immunology

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention

PROJECT_TERMS: Acceleration;Advisory Committees;African American;anti-cancer research;Area;authority;Benchmarking;Businesses;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer prevention;cancer research center director;Catchment Area;Cell Therapy;Clinical;clinical care;Clinical Trials;Colorectal Cancer;Communication;Communities;community advisory board;community building;community engagement;community organizations;Community Outreach;community partners;Comprehensive Cancer Center;Country;Decision Making;Dedications;Disease;Early Diagnosis;Education;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;experience;Faculty;Feedback;Fostering;Funding;Future;Goals;Grant;grasp;Growth;Humanities;improved;Individual;Investments;Lead;Leadership;low dose computed tomography;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;medical specialties;meetings;member;Michigan;Mission;Monitor;operation;outreach;Paper;Patient-Centered Care;Persons;Population Research;Populations at Risk;Positioning Attribute;Process;programs;Recommendation;recruit;Reporting;Research;Research Priority;Resource Allocation;Resource Sharing;rural area;screening;Site;Strategic Planning;success;Time;Training and Education;Translational Research;Travel;Work

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Biotechnology;Cancer

PROJECT_TERMS: Advisory Committees;anti-cancer research;Area;biobank;bioimaging;bioinformatics resource;Bioinformatics Shared Resource;Biomedical Research;Biometry;Cancer Center Support Grant;Cancer Patient;Communication;community engagement;comparative;Comprehensive Cancer Center;Consultations;cost effective;data management;data repository;Development;drug discovery;Ensure;Equipment;Experimental Neoplasms;Flow Cytometry Shared Resource;Future;gene discovery;Gene Targeting;Genomics;Genomics Shared Resource;Goals;Good Manufacturing Process;health communication;Human Resources;Image Cytometry;Immune;improved;Individual;Informatics;Institution;Investigational Drugs;Investments;Leadership;Marketing;member;metabolomics;metabolomics resource;Mission;Modeling;Nicotine;Occupational activity of managing finances;Office Management;Oncology;operation;Pathology;Patient Care;Policies;Process;Productivity;Research;Research Support;Resource Sharing;service delivery;Services;Site;software development;Strategic Planning;Technology;tobacco products;tool;Training;Transgenic Organisms;tumor

PROJECT_TITLE: Shared Resource Management


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: PUZANOV, IGOR  (contact)

PROJECT_TERMS: Adverse event;Amendment;anti-cancer research;Budgets;cancer care;Cancer Center Support Grant;Caring;Catchment Area;Clinic;Clinical;Clinical Data;clinical investigation;Clinical Protocols;Clinical Research;clinical trial implementation;Clinical Trials;Collaborations;COVID-19;Data;data integrity;data management;Databases;Development;Direct Costs;Disease;Doctor of Philosophy;Documentation;Early Therapeutic-Clinical Trials Network;Education;Educational Materials;electronic data;electronic data capture system;Electronics;Ensure;Faculty;Funding;General Hospitals;Goals;Grant;high standard;Industry;Informatics;Informed Consent;Infrastructure;Institution;Institutional Review Boards;Intervention;Investigational New Drug Application;investigator-initiated trial;Leadership;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Manuals;member;Minority;Minority Access;Minority Groups;Monitor;National Cancer Institute;National Clinical Trials Network;New York;Outcome;Ovarian;pandemic disease;participant safety;Performance;Policies;Procedures;Process;Productivity;programs;Protocols documentation;quality assurance;Regulation;Reporting;Reproducibility of Results;Research;Research Activity;Research Personnel;research study;Resources;Review Committee;Safety;Seminal;Services;Site;System;Time;Training and Education;Work

PROJECT_TITLE: Clinical Protocol and Data Management


PROJECT_TERMS: Address;Adverse event;arm;authority;Cancer Center Support Grant;Catchment Area;Clinical;Clinical Management;Clinical Research;Common Terminology Criteria for Adverse Events;Comprehensive Cancer Center;Data;Disease;Elements;Ensure;Evaluation;Frequencies;Funding;Goals;Guidelines;improved;Instruction;Intervention Trial;Investigational Drugs;Link;Malignant Neoplasms;Minority Groups;Mission;Monitor;operation;Process;Protocols documentation;Rare Diseases;recruit;Research;Research Design;Research Personnel;Resources;response;Review Committee;Risk;Safety;Science;Services;Site;Solid Neoplasm;System;Therapeutic Intervention;Time

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE Mental illness affects approximately 15% of the population, creates enormous disability and cost, and has been stubbornly persistent over the decades. To fundamentally alter this trajectory we must recruit and train the next generation of physician-scientist researchers who will generate the advances in diagnosis, treatment, prevention, and cure that we need to alleviate this burden. Yale’s T32-funded Clinical Neuroscience Research Training Program, of which this is a renewal application, has an exceptional track record of training psychiatric physician-scientists, which we here aim to continue and enhance.

PI_NAMEs: PITTENGER, CHRISTOPHER JOHN (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TITLE: Clinical Neuroscience Research Training Program in Psychiatry

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (01)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE With the rise in the impact of cardiovascular disease on U.S. and world health, and the rapid advances in imaging technologies and cardiovascular biology, it is critical to train the next generation of investigators in technology- based cardiovascular imaging research. Stanford University has world-class faculty, the necessary resources, and the collaborative milieu to address the major public health problem of cardiovascular disease. This multidisciplinary T32 training program in Cardiovascular Imaging at Stanford (CVIS) is designed to train postdoctoral fellows in clinical, engineering, and molecular imaging technology, and to foster their development into investigators dedicated to identifying innovative solutions and capable of translating basic research into clinical success to combat cardiovascular diseases.

PI_NAMEs: NIEMAN, KOEN ;PAULY, JOHN M.;WU, JOSEPH C. (contact)

PROGRAM_OFFICER_NAME: ERIM, ZEYNEP

PROJECT_TITLE: Multi-Disciplinary Training Program in Cardiovascular Imaging at Stanford

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-D (J1)]


PHR: Project Narrative This proposal aims to maintain and expand a residency research training program that recruits medical graduates with demonstrated research experience and prepares them to become independent physician- scientists with careers in psychiatric or neuroscience research, a key NIMH goal. This 4-year program will provide participants with extensive mentorship, formal research training, access to pilot funding, and protected research time. Program trainees will be well-prepared to rapidly progress on the path to NIH K or R awards, accelerating the transition to careers as independent investigators who can address cutting edge psychiatric and neuroscience challenges with public health impact.

PI_NAMEs: DE BIASI, MARIELLA ;KAYSER, MATTHEW S;OQUENDO, MARIA A (contact)

PROJECT_TERMS: Acceleration;Address;Applications Grants;Attention;Award;Basic Science;career;career development;Clinical;clinical care;Clinical Research;Clinical Sciences;clinical training;Collaborations;Communities;Complex;Data Collection;Dedications;Development;Development Plans;education research;Engineering;Environment;Ethics;Ethnic Origin;experience;Extramural Activities;Fellowship;flexibility;Foundations;Funding;Gender;Goals;Heart;Historically Black Colleges and Universities;Individual;innovation;Institution;Interdisciplinary Study;interest;K-Series Research Career Programs;Lead;Leadership;Learning;Medical;medical schools;Medicine;meetings;Mental Health;Mentors;Mentorship;Mission;Monitor;National Institute of Mental Health;Neurology;Neurosciences;Neurosciences Research;next generation;novel;Participant;Pediatric Hospitals;Pennsylvania;Personal Satisfaction;Philadelphia;Physicians;Positioning Attribute;Preparation;programs;Psychiatrist;Psychiatry;Public Health;Publications;Race;recruit;Religion;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;Residencies;Risk;Schools;Scientist;skills;Socioeconomic Status;Structure;Students;success;Supervision;Talents;Time;Training;training opportunity;Training Programs;translational neuroscience;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Update;Veterans Hospitals;Veterinary Medicine;Visit;Writing

PROJECT_TITLE: Educating Physician Scientists in Psychiatry (EPSP): Firing up the next generation of translational and clinical neuroscientists

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (01)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology

PHR: Project Narrative Mass spectrometry is a powerful and robust technique for the analysis and quantification of complex collection of proteins, peptides, lipids, and small molecule metabolites. Currently, there is only a single mass spectrometer at the University of Rochester (UR) available for proteomic experiments. This instrument is currently being used at full capacity and lacks functional capabilities that are required or advantageous for several ongoing NIH-funded projects being conducted by the user-base of the UR Mass Spectrometry Resource Laboratory (MSRL). The proposed purchase of the timsTOF HT mass spectrometry system will facilitate proteomic experiments at UR by providing researchers a suite of novel tools that take advantage of the Trapped Ion Mobility (TIMS) analyzer and Parallel Accumulation and Serial Fragmentation (PASEF) features of the instrument. Specifically, the rapid sequencing speeds of the instrument will greatly alleviate project backlogs, reduce turnaround times and bring down the per-experiment costs of proteomics projects. These capabilities will enhance the ability of UR researchers to conduct large-scale proteomic experiments that require high proteome coverage and large number of samples and replicates. A number of projects described by the users of this instrument have clinical implications and will be analyzing proteomes within disease models that have direct relevance to the development of therapies that can improve human health. These projects, which are funded by 20 NIH grants, either require or will be significantly aided by the requested timsTOF HT instrument.

PI_NAMEs: GHAEMMAGHAMI, SINA  (contact)

PROGRAM_OFFICER_NAME: CHEN, YONG

PROJECT_TERMS: 3-Dimensional;Address;Aging;Area;base;biological research;Charge;Clinical;college;Communities;computerized data processing;Core Facility;Data;data acquisition;Data Analyses;Data Storage and Retrieval;Dedications;Detection;Development;Ensure;experience;Fingerprint;Funding;high throughput analysis;Institution;instrument;instrumentation;ion mobility;Ions;Label;Laboratories;Laboratory Research;liquid chromatography mass spectrometry;mass spectrometer;Mass Spectrum Analysis;Medical center;Medical Research;member;Minor;Modernization;New York;programs;Property;Protein Analysis;protein complex;Proteomics;Reproducibility;Research;Research Project Grants;Resolution;Resources;Running;Services;Speed;System;Technology;Time;tool;United States National Institutes of Health;Universities

PROJECT_TITLE: timsTOF HT LC-MS System for UR Proteomics Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-T (30)]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE. The fields of microbiology and immunology (M&I) have been at the epicenter of recent transformative scientific discoveries as well as unprecedented public health challenges that have fueled demand for professionals in these fields. Translating these discoveries into novel strategies to combat pathogens and improve human health involves complex interdisciplinary research and requires the broad perspectives of a science and healthcare workforce that reflects the diverse skills and peoples of our nation. To fill this acute workforce need, the Supporting Under-represented Minorities in Microbiology and Immunology Research (SUMMIR) program will utilize the robust resources of the University of Maryland School of Medicine and partner institutions to provide integrated research experiences, courses for skills and professional development and multi-faceted mentoring that will inspire undergraduate interns who comprise the next generation of leaders in these fields.

PI_NAMEs: HARBERTS, ERIN MARIE;HASSEL, BRET A (contact);SCANLON, KAREN

PROJECT_TERMS: Active Learning;Acute;Admission activity;antimicrobial;Baltimore;Basic Science;Black race;Career Choice;Career Mobility;career networking;Cities;Clinical Research;cohort;combat;Communities;Community Outreach;Complex;Course Content;Databases;Dedications;Development;Diverse Workforce;Educational Activities;Educational process of instructing;Educational workshop;effectiveness evaluation;Engineering;Environment;Equity;experience;Faculty;faculty mentor;Fostering;Foundations;Goals;hands on research;Health;Health Personnel;Healthcare;Historically Black Colleges and Universities;Human;Immunology;improved;Individual;innovation;Institution;Interdisciplinary Study;interest;Internships;junior high school;Laboratories;Laboratory culture;Leadership;Learning Module;lectures;LinkedIn;Maryland;medical schools;Mentors;Microbiology;Minority;Mission;Modernization;National Institute of Allergy and Infectious Disease;next generation;novel;novel strategies;Outcome;outreach;pathogen;peer;peer coaching;Persons;Population;postgraduate education;Program Sustainability;programs;Public Health;recruit;Research;Research Personnel;Research Project Grants;Resources;Schools;Science;Services;skill acquisition;skills;success;summer internship;symposium;Talents;teaching laboratory;Techniques;Therapeutic;Training and Education;Training Technics;Translating;undergraduate education;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;Universities;University resources;workforce needs

PROJECT_TITLE: Supporting Under-Represented Minorities in Microbiology and Immunology Research (SUMMIR)


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: DERMATOLOGY

PHR: The goal of the Penn Dermatology Research T32 Training Program is to train the next generation of independent investigators to become leaders in cutaneous biology and dermatology. Skin diseases are very prevalent, represent a major health burden, and have a profound impact on quality of life. By training diverse, multi-disciplinary investigators that span basic, translational, and clinical research, we seek to improve mechanistic understanding and identify novel therapeutic targets for skin disease, leading to improved health and overall quality of life.

PI_NAMEs: GRICE, ELIZABETH ANNE (contact);MARGOLIS, DAVID

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: Penn Dermatology Research Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 SP (M1)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE The current and future success of science in solving the drug addiction problem is dependent on collaborative partnerships between diverse researchers, clinicians, and affected communities that deliver discovery to addiction prevention and clinical care. Attaining this goal is increasingly dependent on interdisciplinary, team- based, clinical and community translational research and the ultimate objective of this training program is to develop this next generation of addiction investigators. As the sole NIDA T32 training program at the only academic medical center in the state of Arkansas, the proposed program seeks to use training and career development to meaningfully impact the immense public health problem of drug addiction at both the national, regional, and state levels.

PI_NAMEs: FANTEGROSSI, WILLIAM E;ZIELINSKI, MELISSA JEAN (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: addiction;Training

PROJECT_TITLE: Translational Training in Addiction

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 MXS-T (J1)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: This long-standing training program in Environmental Health Sciences at Johns Hopkins University provides state of the art training for the next generation of scientists in environmental sciences with the purpose of detection and evaluation of the health impacts of hazardous environmental agents on susceptible populations and the development of prevention/treatment strategies that will mitigate the impact of these exposures on human health.

PI_NAMEs: WILLS-KARP, MARSHA  (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Environmental Health;Training Programs

PROJECT_TITLE: Training Program in Environmental Health Sciences

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS (T)]


ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE The Cell and Molecular Biology Training Grant seeks to broadly train PhD students in cell and molecular biology to adapt to changing needs in the biomedical research work force. This Predoctoral Training Program includes education and research opportunities to investigate the molecular and cellular basis of fundamental biological processes that range from cell signaling and architecture to gene expression, employing a wide array of model systems and state of the art imaging, molecular/cellular assays, and high throughput technologies. Career development opportunities are also central to the training program.

PI_NAMEs: BARTOLOMEI, MARISA S. (contact);MARKS, MICHAEL S

PROJECT_TERMS: Cellular biology;Molecular Biology;Training Programs

PROJECT_TITLE: Training Program in Cell and Molecular Biology

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The Training Program in Precision Environmental Health Sciences (TPEHS) is a joint initiative of Baylor College of Medicine, The University of Texas Health Science Center at Houston Schools of Public Health and of Biomedical Informatics, and The University of Texas MD Anderson Cancer Center. This multidisciplinary program provides the next generation of pre- and post-doctoral trainees the skills to be successful working at the intersection of Genomics/epigenomics, Environmental Health, and Data Science to improve our understanding of environment influences on human health and disease.

PI_NAMEs: WALKER, CHERYL L. (contact)

PROJECT_TERMS: Environmental Health;Training

PROJECT_TITLE: Training in Precision Environmental Health Sciences


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Aging;Arthritis;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Neurodegenerative;Neurosciences;Osteoarthritis;Pain Research;Peripheral Neuropathy;Women's Health Research

ORG_CITY: BIDDEFORD

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NEW ENGLAND

ORG_STATE: ME

PHR: Project Narrative Osteoarthritis (OA) pain is heterogeneous with distinct mechanisms across stages of OA pain that are poorly understood and contributes to the variable therapeutic efficacy of treatments for OA pain. Moreover, OA pain is more common and reported to be more severe in females compared to males. This grant explores whether pathological changes in innervation of the OA joint and adjacent muscle determines transition between mid- stage and advanced OA pain and whether this occurs in a sex dependent fashion that increases susceptibility of females to develop more severe OA joint pain.

PI_NAMEs: KING, TAMARA E (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: activating transcription factor 3;Address;afferent nerve;Afferent Neurons;Animals;Applications Grants;Arthralgia;Arthritis;Axon;axon injury;Cell Nucleus;Cells;chronic pain;comparison control;Data;Degenerative polyarthritis;Diameter;Disabling condition;Female;Fiber;Future;Grant;High Prevalence;Human;immunoreactivity;Impairment;improved;Incidence;individualized medicine;innovation;insight;Investigation;joint destruction;joint injury;Joint Instability;Joints;Knee joint;Knee Osteoarthritis;Label;male;Modeling;mouse model;Mus;Muscle;Muscle function;Nerve;nerve damage;Nerve Fibers;nerve injury;nerve supply;neuronal cell body;Neurons;Nociceptors;osteoarthritis pain;Pain;Pain management;pain patient;painful neuropathy;Pathologic;Pathology;Patients;Persistent pain;Phenotype;Population;Predisposition;Recommendation;Reporting;Resistance;Rest;Role;selective expression;Sensory;sex;Sex Differences;sexual dimorphism;Spinal Ganglia;Techniques;Therapeutic;Thinness;tibialis anterior muscle;Tissues;Treatment Efficacy;treatment strategy;women versus men

PROJECT_TITLE: Mechanisms underlying sex differences in emergence of advanced osteoarthritis pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-A (SU)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: LEXINGTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Living stock resources are needed for the Mexican axolotl so that investigators can develop research models and translate biological information that is relevant to human health and disease. The Mexican axolotl is a primary vertebrate model for organ regeneration, tissue repair, and post-embryonic development.

PI_NAMEs: VOSS, STEPHEN RANDAL (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Acceleration;Address;Adolescent;Adopted;Adult;Ambystoma;Ambystoma mexicanum;Animals;Area;Award;Biological;Biomedical Research;Body part;Brain;Breeding;Cellular biology;Collaborations;Collection;Communities;Complement;Computer software;cost;Cryopreservation;Custom;Data;data management;Data Reporting;Databases;design;Development;Disease;Education;electronic data;Embryo;Embryonic Development;Ensure;Equipment and supply inventories;Evolution;Funding;Future;Genes;Genetic;genetic resource;Genome;Genomics;Germ;handheld equipment;Health;health record;Heart;Human;improved;Informatics;Infrastructure;International;Jaw;Kentucky;Knock-out;Laboratories;Life;Limb structure;Louisiana;Metadata;Methods;Modeling;multiple data types;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of General Medical Sciences;National Institute of Neurological Disorders and Stroke;Natural regeneration;Neurobiology;operation;Organ Model;organ regeneration;outreach;Physiology;Population;Positioning Attribute;Postembryonic;Practice Management;preservation;Process;Protocols documentation;recruit;Reproducibility;Research;Research Personnel;Research Support;Resources;Retina;Retrieval;Salamander;Shipping;single-cell RNA sequencing;sperm cell;sperm cryopreservation;Spinal Cord;System;Tail;Technology;Time;timeline;tissue repair;Tissues;Transgenic Organisms;Translating;United States National Institutes of Health;Universities;user friendly software;Vertebrates;water quality;web site;wireless;Work;Writing

PROJECT_TITLE: Ambystoma Genetic Stock Center - Revision to Include Curation and Informatics Component

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-J (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Alzheimer’s disease and related dementias refer to a wide group of relentless neurodegenerative diseases, with as yet unknown etiologies. This renewal application seeks continued funding to train predoctoral students studying clinical and translational aspects of Alzheimer’s disease and related dementias. Trainees from diverse backgrounds will receive support to participate in didactic coursework, mentored research and professional development in preparation for a future career in clinical and translational research in Alzheimer’s disease and related dementias.

PI_NAMEs: CHAKRABARTY, PARAMITA ;LEWIS, JADA M (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Alzheimer's disease related dementia;Clinical;pre-doctoral;Training

PROJECT_TITLE: Clinical and Translational Predoctoral training in Alzheimers Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (J2)]


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE Although soft tissue sarcomas can be treated surgically, for patients with advanced disease there are few effective systemic therapies. By discovering the molecular alterations that drive the formation and growth of sarcomas, we have an opportunity to identify new types of therapy for these deadly diseases. This insight into sarcoma biology will also allow for more precise diagnosis and prognosis and will identify biomarkers that predict how the tumor will respond to specific treatments.

PI_NAMEs: SINGER, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: UJHAZY, PETER

PROJECT_TERMS: Adjuvant Therapy;Adult;advanced disease;Animal Cancer Model;animal model development;Automobile Driving;Biological;Biological Markers;Biology;biomarker identification;biomarker validation;Blood Banks;Cancer Center Support Grant;cancer/testis antigen;career;Cell Line;Childhood;Clinic;Clinical;clinical application;clinical care;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Collection;Combined Modality Therapy;Complex;Core Facility;Data;Data Set;Databases;Dedications;Dependence;design;Development;Diagnosis;Disease;efficacy testing;engineered T cells;Epigenetic Process;experience;Genetic;Goals;Grant;Growth;Histologic;Human;human model;Immunotherapy;improved;Infrastructure;inhibitor;innovation;insight;Institution;inter-institutional;Investigation;Investigational Therapies;Link;Malignant Neoplasms;Medical Informatics;Methylation;Modeling;Molecular;Molecular Genetics;Morbidity - disease rate;mortality;multidisciplinary;Natural History;neoantigens;new therapeutic target;novel;novel marker;Operative Surgical Procedures;Outcome;outcome prediction;Pathogenesis;Pathologic;Pathway interactions;Patient Care;patient derived xenograft model;patient population;Patient risk;Patients;Population;preclinical development;predictive marker;predictive modeling;Prognosis;prognostication;programs;prospective;recruit;Research;Research Project Grants;Resistance;resistance mechanism;Resources;response;Risk Assessment;risk selection;RNA vaccine;Role;Sarcoma;Scientist;Signal Pathway;Soft tissue sarcoma;specific biomarkers;Specimen;Standardization;Structure;synergism;synovial sarcoma;Systemic Therapy;T-Cell Receptor;targeted treatment;Therapeutic;therapeutic target;therapy development;Tissue Banks;Tissues;Toxic effect;Translating;Translational Research;tumor;Xenograft procedure

PROJECT_TITLE: SPORE in Soft Tissue Sarcoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-6 (J1)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Rare Diseases

PROJECT_TERMS: Bioinformatics;Biological Specimen Banks;Biometry;blood resource;career;Cell Line;Clinical;Clinical Management;Clinical Trials;Collaborations;Communication;Communities;Data;data management;Databases;Development;Education;Ensure;Epigenetic Process;Ethnic Population;experience;Fostering;Genetic;Genomics;Grant;Human Resources;Institution;Laboratories;Link;Medical;meetings;member;Molecular;Monitor;Occupational activity of managing finances;Office of Administrative Management;operation;Pathology;Patient advocacy;Patient Compliance;patient privacy;Principal Investigator;programs;quality assurance;racial population;Regulation;Reporting;Reproduction spores;Research;Research Personnel;Research Project Grants;Services;Soft tissue sarcoma;Structure;symposium;Tissue Banks;tissue resource;Training;Translational Research;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Precision Medicine;Rare Diseases

PHR: RP1: Molecular Determinants of GIST Pathogenesis Narrative Gastrointestinal stromal tumor (GIST), a common subtype of soft tissue sarcoma, often exhibits aggressive clinical behavior, and is incurable in advanced and metastatic settings. Through genomic and clinical analysis of large cohorts of patients with GIST, we associated MAX/MGA/MYC genetic alterations and arm-level deletions of 1p with metastatic GIST and poor relapse-free survival in resected GIST. Here, we propose comprehensive, collaborative, and multidisciplinary studies to investigate the mechanisms of MAX/MGA/MYC perturbation involved in aggressive GIST behavior, identify, and validate molecular biomarkers predictive of recurrence risk, and develop a combinatorial pathologic-genomic nomogram to guide adjuvant imatinib therapy decisions and identify novel strategies to target metastasis in advanced GIST.

PI_NAMEs: CHI, PING  (contact)

PROJECT_TERMS: Adjuvant;Adjuvant Therapy;arm;Assessment tool;Behavior;behavior in vitro;Biological Markers;cancer genomics;cell behavior;Cell Cycle;Cell Differentiation process;cell growth regulation;Cell Physiology;Cells;Chromatin;chromosome 5q loss;classification trees;Clinical;clinical care;clinical investigation;clinical practice;cohort;combinatorial;Complex;Coupled;Critical Care;Decision Trees;Disease Progression;Engineering;epigenome;ETV1 gene;Event;Evolution;Excision;Exhibits;FOXF1 gene;Gastrointestinal Neoplasms;Gastrointestinal Stromal Tumors;Gene Mutation;Genetic;Genome;Genomics;Goals;Helix-Turn-Helix Motifs;Heterodimerization;high risk;Human;Imatinib;improved;In Vitro;in vivo;Indolent;Investigation;Knowledge;Leucine Zippers;Location;Logistic Regressions;loss of function mutation;Loss of Heterozygosity;Machine Learning;Malignant Neoplasms;Mesenchymal Cell Neoplasm;Metabolism;migration;Mitotic;Modeling;Molecular;molecular marker;multidisciplinary;multiple omics;mutant;Mutation;Neoplasm Metastasis;Nomograms;Nonmetastatic;novel;novel strategies;novel therapeutic intervention;Oncogenic;Operative Surgical Procedures;Pathogenesis;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;PDGFRA gene;PRC1 Protein;pre-clinical;predictive marker;predictive modeling;Primary Neoplasm;prognostic value;prospective;Receptor Protein-Tyrosine Kinases;Recurrence;Regression Analysis;regression trees;Relapse;Resectable;Resected;response;Risk;Risk Assessment;risk stratification;Sampling;Sarcoma;Scheme;single cell ATAC-seq;single nucleus RNA-sequencing;Site;Soft tissue sarcoma;Survival Analysis;System;Transcription Coactivator;transcription factor;transcriptome;Translational Research;Trees;tumor;tumor behavior;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;Tyrosine Kinase Inhibitor;United States National Institutes of Health;Unresectable;Validation;Variant

PROJECT_TITLE: Project 1: Molecular Determinants of GIST Pathogenesis


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Orphan Drug;Precision Medicine;Rare Diseases

PHR: RP2: Targeting Hippo Pathway Dependence in Genetically Complex Sarcomas NARRATIVE New treatment options are urgently needed for the most common and clinically aggressive types of sarcoma with complex genomic alterations: well-differentiated and dedifferentiated liposarcomas, myxofibrosarcoma, and undifferentiated pleomorphic sarcoma. The proposed studies will elucidate the role of the Hippo signaling pathway and the translation factor eIF4A in these deadly sarcomas and will include preclinical testing of a new eIF4A inhibitor. By advancing eIF4A inhibition toward clinical trials, the proposed work will likely lead to more effective treatment for patients with genetically complex sarcomas and perhaps other eIF4A-dependent cancers.

PROJECT_TERMS: ABCB1 gene;advanced disease;antitumor effect;Automobile Driving;Biological Markers;Bypass;Cancer Model;cell growth;Cell Line;Cell model;Cell Proliferation;Cells;Clinic;Clinical;Clinical Trials;Collaborations;combat;Combined Modality Therapy;common treatment;Complex;Critical Pathways;Data;Dedifferentiated Liposarcomas;Dependence;design;Development;DNA Sequence Alteration;DNA sequencing;Drug Kinetics;Drug resistance;effective therapy;efficacy evaluation;efficacy study;Feedback;FRAP1 gene;Gene Dosage;Gene Expression Profile;genetic signature;Genetically Engineered Mouse;Genomics;Genotype;Goals;Growth;Histologic;Human;Immune Targeting;Immunocompetent;improved;inhibitor;innovation;Institution;Invaded;knock-down;Lead;liposarcoma;Malignant Fibrous Histiocytoma;Malignant Neoplasms;MAP Kinase Gene;Maps;meetings;Messenger RNA;migration;Modeling;molecular subtypes;mRNA Expression;mRNA Translation;Mus;Myxoid Malignant Fibrous Histiocytoma;Neoplasm Metastasis;new therapeutic target;novel drug class;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncogenic;Oncoproteins;Operative Surgical Procedures;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patient risk;Patient-Focused Outcomes;Patients;Pattern;Pharmacology Study;Phase;Phase I Clinical Trials;PIK3CG gene;pre-clinical;Pre-Clinical Model;precision oncology;preclinical efficacy;preclinical safety;Preclinical Testing;predictive marker;Prodrugs;Production;Prognostic Marker;Proliferating;Proteins;Proto-Oncogene Proteins c-akt;Recurrent disease;Regimen;Relapse;Research Project Grants;Resistance;ribosome profiling;Ribosomes;Risk Assessment;RNA Helicase;Role;Sampling;Sarcoma;Series;Signal Pathway;Signal Transduction;Soft tissue sarcoma;targeted treatment;Testing;Therapeutic;Tissue Sample;Toxic effect;Transcription Coactivator;transcriptome sequencing;translation factor;Translations;treatment strategy;trial design;tumor;tumorigenesis;Work;Xenograft Model

PROJECT_TITLE: Project 2: Targeting the Hippo Pathway in Genetically Complex Sarcomas


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunization;Immunotherapy;Orphan Drug;Rare Diseases;Vaccine Related

PHR: RP3: Identifying Targetable Epigenetic and Immuno-Oncologic Vulnerabilities in Synovial Sarcoma NARRATIVE This project will develop and evaluate new treatment strategies for synovial sarcoma by (1) examining how a specific genetic alteration affects epigenetic regulation and identifying anticancer drugs that target the resulting vulnerabilities, (2) developing an engineered T cell-based therapy to recognize the protein resulting from the fusion of two genes that occurs only in synovial sarcoma, and (3) evaluating the efficacy and immunogenicity of an mRNA vaccine designed to induce immune responses to the fusion protein and other synovial sarcoma- specific antigens, in combination with an immune-modulating antibody in a clinical trial.

PI_NAMEs: LADANYI, MARC  (contact)

PROJECT_TERMS: 2019-nCoV;Affect;Amino Acid Sequence;anti-PD-L1 antibodies;Antibodies;Antigens;Antineoplastic Agents;Biological Response Modifiers;cancer genomics;cancer/testis antigen;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Line;Cells;Chemicals;Childhood;Chimeric Proteins;Chromatin;Clinical;Clinical Trials;Clonal Expansion;cohort;Collaborations;COVID-19 pandemic;CTAG1 gene;Data;Dependence;derepression;DNA Methylation;Drug Targeting;efficacy evaluation;Endogenous Retroviruses;engineered T cells;Epigenetic Process;epigenetic regulation;epigenetic therapy;Epitopes;experience;Gene Transfer;Genes;Genetic;Genetic Transcription;genomic profiling;Genomics;Goals;Haplotypes;Histones;Immune;Immune response;Immunity;Immunization;Immunobiology;immunodeficiency;immunogenic;immunogenicity;immunoregulation;Immunotherapy;In Vitro;in vivo;innovation;Interdisciplinary Study;Interferon Type I;Libraries;loss of function;Lysine;Measures;Mediating;Messenger RNA;Metastatic Synovial Sarcoma;Metastatic/Recurrent;Methylation;Methyltransferase;Modeling;Mus;Mutation;neoantigens;novel;novel therapeutic intervention;Patients;Peptides;Phase I/II Clinical Trial;Polycomb;polypeptide;Population;preferentially expressed antigen in melanoma;programs;prospective;protein aminoacid sequence;Proteins;Proteolytic Processing;Recurrence;Resectable;response;retroviral transduction;RNA vaccine;Safety;Sarcoma;Soft tissue sarcoma;synergism;synovial sarcoma;T cell response;T cell therapy;T-Cell Receptor;T-Cell Receptor Genes;T-Lymphocyte;Testing;Therapeutic;Time;Tissues;tumor;Vaccine Design;vaccine platform;Vaccines;Xenograft procedure;young adult

PROJECT_TITLE: Project 3: Identifying Targetable Epigenetic and Immuno-Oncologic Vulnerabilities in Synovial Sarcoma


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Rare Diseases

PI_NAMEs: ANTONESCU, CRISTINA R (contact)

PROJECT_TERMS: Animal Model;Animals;Apoptosis;Archives;Basic Science;Bioinformatics;Biological Assay;Biological Specimen Banks;Biometry;Blood;Cancer Center;Cell Line;Cell Survival;Center Core Grants;Clinical;clinical database;Clinical Trials;Collaborations;Collection;Correlative Study;cost effective;Databases;design;digital;Ensure;Evaluation;Fibrosis;Fluorescent in Situ Hybridization;Formalin;Freezing;Generations;Genes;Genetic Screening;Human;human tissue;Image;immune cell infiltrate;immunohistochemical markers;Individual;Induction of Apoptosis;Infrastructure;Institution;Institutional Review Boards;Microscopic;Molecular;Molecular Abnormality;Morphology;mouse model;Mus;Mutation;Necrosis;Normal tissue morphology;novel;Nucleic Acids;Office of Administrative Management;Paraffin Embedding;participant enrollment;Pathologic;Pathology;peripheral blood;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Pilot Projects;Plasma;Play;programs;Proliferating;Protocols documentation;Research;Research Personnel;Research Project Grants;Resources;response;Role;Sampling;Sarcoma;Scanning;Serum;Services;Soft Tissue Neoplasms;Soft tissue sarcoma;Specimen;tissue archive;Tissue Embedding;Tissue Microarray;tissue preparation;Tissue Sample;Tissues;Translational Research;treatment response;tumor;Validation;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Core A: Biospecimen Repository and Pathology


PI_NAMEs: QIN, LI-XUAN  (contact)

PROJECT_TERMS: Address;analytical method;Attention;Bioinformatics;bioinformatics pipeline;Biological Assay;Biological Specimen Banks;biomarker identification;Biometry;Biostatistics Core;Cell Line;Center Core Grants;Clinical;Clinical Data;Clinical Research;clinical trial analysis;Clinical Trials;Collaborations;comparison group;Consult;Core Facility;Data;Data Analyses;data format;Data Sources;Databases;Deposition;design;Disease;diverse data;Doctor of Philosophy;Ensure;experience;Experimental Designs;genomic data;Goals;Graph;Human;Institution;laboratory experiment;Laboratory Research;Leadership;Manuscripts;member;Memorial Sloan-Kettering Cancer Center;Methodology;Methods;Molecular;Molecular Analysis;molecular marker;Molecular Profiling;mouse model;novel;outcome prediction;Pathology;Patient advocacy;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Population;Preparation;primary endpoint;Procedures;protocol development;Protocols documentation;public repository;Publications;Randomized;Reporting;Reproducibility;Research;research data dissemination;Research Design;Research Personnel;Research Project Grants;research study;Resources;response;Sample Size;Sampling;Sarcoma;Science;secondary endpoint;Soft tissue sarcoma;Statistical Data Interpretation;survival outcome;Testing;translational cancer research;translational goal;tumor;Update;Validation;Work;Writing

PROJECT_TITLE: Core B: Biostatistics and Bioinformatics Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Rare Diseases

PI_NAMEs: TAP, WILLIAM D. (contact)

PROJECT_TERMS: Adult;Advocacy;Advocate;Affect;Age;age group;Area;Attention;Awareness;Basic Science;Bioinformatics;Biological;Biological Markers;Biology;Biometry;Cancer Center;Cancer Therapy Evaluation Program;Caregivers;Caring;Childhood;childhood sarcoma;Clinical;Clinical Cancer Center;Clinical Research;clinical trial protocol;Clinical Trials;Clinical Trials Unit;Collaborations;community collaboration;Complement;Conduct Clinical Trials;Correlative Study;cost effective;Data Analyses;Data Collection;design;Development;Developmental Therapeutics Program;Disease;disorder subtype;Early Therapeutic-Clinical Trials Network;Education;Ensure;Epigenetic Process;Epithelium;experimental study;Financial Support;Genetic;Government;Hematopoietic Neoplasms;Immunotherapeutic agent;improved;Individual;Infrastructure;Liquid substance;Malignant Neoplasms;member;Memorial Sloan-Kettering Cancer Center;Mesenchymal;novel;novel therapeutics;Oncologist;Oncology;outreach;Participant;Pathogenicity;Pathology;Patient advocacy;patient advocacy group;patient population;Patient Recruitments;Patients;Performance;Pharmacologic Substance;pre-clinical;prevent;Process;Prognosis;programs;Protocols documentation;Rare Diseases;Research;Research Personnel;Research Project Grants;Resources;Running;sample collection;Sarcoma;Site;Soft tissue sarcoma;Structure;Survival Rate;Therapeutic;translational goal;Translational Research;Translations;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Work

PROJECT_TITLE: Core C: Clinical Trials and Patient Advocacy


PROJECT_TERMS: Address;Animals;Award;Biology;Budgets;Clinical;Clinical Trials;Collaborations;Complement;Creativeness;Development;Diagnosis;Funding;Future;Generations;Goals;Growth;Human;improved;innovation;Institution;Intervention;Investigator-Initiated Research;Knowledge;Leadership;member;Memorial Sloan-Kettering Cancer Center;Natural History;Pathogenesis;Patients;Philanthropic Fund;preference;Procedures;Process;Prognosis;Program Research Project Grants;programs;Publications;recruit;Research;Research Personnel;Research Project Grants;Research Support;Sarcoma;Soft tissue sarcoma;stem;success;Talents;Testing;Translational Research;Underrepresented Populations;Women's Group

PROJECT_TITLE: Developmental Research Program


PI_NAMEs: HAMEED, MEERA  (contact)

PROJECT_TERMS: Appointment;Attention;Award;career;Career Choice;career development;Cellular biology;Clinical;Clinical Investigator;Clinical Pathways;Collaborations;Colon Carcinoma;Computational Biology;Core Facility;Dedications;Development Plans;Diagnosis;Disease;Disease Management;Education;Educational Curriculum;Eligibility Determination;Ensure;Faculty;Funding;Goals;Grant;Individual;innovation;Institution;interest;Investigation;investigator training;Knowledge;Laboratories;Laboratory Scientists;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;medical schools;meetings;member;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;minority investigator;Molecular Biology;Monitor;Pathway interactions;Peer Review;Physicians;programs;Publications;Qualifying;Recording of previous events;recruit;Reproduction spores;Research;Research Personnel;Research Project Grants;Research Support;Sarcoma;Scientist;skills;Soft tissue sarcoma;Source;success;symposium;Systems Biology;Talents;Time;Training;Training and Education;translational cancer research;translational impact;translational potential;Translational Research;Underrepresented Minority;Underrepresented Populations;Universities;Woman

PROJECT_TITLE: Career Enhancement Program


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: Drexel University proposes to establish a robust and innovative program, Drexel DREAM (Diversity, Research, Experiential Learning, Research Skills and Aging Science, and Mentorship) Scholars Program, to enhance the diversity of the biomedical, behavioral, and clinical research workforce in aging research. The DREAM Scholars program is built upon 5 pillars: 1) leverages the university’s commitment to diversity in students, faculty, and staff, and health equity in the communities we serve; 2) faculty expertise in aging research approaches that span the continuum from the bench to policy in three key thematic areas: preventing and managing chronic conditions, enhancing active and purposeful living, and enabling aging in place; 3) experiential learning; 4) an innovative virtual learning community where students obtain digital badges for mastering new knowledge in research skills and aging science; and 5) faculty mentorship for each DREAM Scholar throughout their undergraduate studies. We will recruit and train 22 underrepresented minority (URM) students who completed freshman year to participate in the DREAM Summer track- a noncredit full-time 10- week paid summer aging research training and 38 URM students in their sophomore, pre-junior, or junior year, to participate in the DREAM CO-OP Scholar Track- a noncredit full-time 26-week paid aging research training program as their cooperative education rotation.

PI_NAMEs: DIMARIA-GHALILI, ROSE ANN (contact);SELL, CHRISTIAN

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Achievement;Active Learning;Aging;aging in place;anti-racism;Area;Articulation;Awareness;Behavioral Research;Biomedical Research;career;Cells;Chronic;Clinical Research;Collaborations;college;Communities;cultural equity;Data;digital;Discipline of Nursing;E-learning;Education;effectiveness evaluation;Equity;essays;experience;Exposure to;Faculty;faculty mentor;Fostering;Funding;Future;Goals;graduate school;Grant;health equity;Health Occupations;implementation evaluation;implementation process;innovation;International;Knowledge;Learning;learning community;Medicine;member;Mentors;Mentorship;Oral;Paper;Personal Growth;Policies;posters;prevent;Program Sustainability;programs;recruit;Reporting;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;response;responsible research conduct;Review Literature;Rotation;Scholars Program;Scholarship;Science;Scientist;Shapes;skills;social health determinants;Societies;statistics;Students;theories;Thinking;Training;Training Programs;undergraduate education;undergraduate student;underrepresented minority student;Universities;Writing

PROJECT_TITLE: Drexel DREAM (Diversity, Research, Experiential Learning, Aging Science, and Mentorship) Scholars Program


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: SAN JOSE

ORG_NAME: SAN JOSE STATE UNIVERSITY

PHR: PROJECT NARRATIVE: Molecular mediators of muscle spindle mechanosensation. The ability to move through an unpredictable environment relies on stretch-sensitive sensory neurons in the muscle and many conditions, including aging, chemotherapy treatment, and neuromuscular diseases, can impair the function of these neurons. This research investigates how altered function in proteins necessary for the function of these sensory neurons, including the mechanically sensitive ion channel PIEZO2, impairs their ability to sense and transmit muscle movement information. The results of these studies will provide important information about how these sensory neurons work and determine whether the consequences of dysfunction in these proteins differs if it occurs throughout the lifespan or starts in adulthood.

PI_NAMEs: WILKINSON, KATHERINE ANNE (contact)

PROGRAM_OFFICER_NAME: BISSONETTE, GREG

PROJECT_TERMS: Action Potentials;Adult;Affect;Afferent Neurons;Aging;Anatomy;Angelman Syndrome;arm;Arthrogryposis;body position;body sense;chemotherapy;Chemotherapy-induced peripheral neuropathy;Compensation;Data;Development;Dietary Fats;Disease;Distal;Electrophysiology (science);Environment;Functional disorder;gain of function mutation;Gait;Genes;Genetic Diseases;Glutamates;Goals;Impairment;improved;insight;Ion Channel;Ion Channel Gating;Late-Onset Disorder;Length;life span;Mechanics;Mechanoreceptors;mechanotransduction;Mediating;Mediator;Membrane;Modeling;Molecular;Molecular Target;Motor;motor behavior;motor deficit;mouse model;Movement;Muscle;Muscle function;Muscle Spindles;Mutation;Neuromuscular Diseases;neuronal cell body;Neurons;Phase;Phenotype;Piezo 2 ion channel;Positioning Attribute;Property;Proprioception;Proprioceptor;Proteins;Reflex action;Reporting;Research;response;SCN1A protein;Sensory;Severities;Sodium Channel;stretch reflex;Stretching;Supplementation;Testing;Time;Translating;transmission process;vesicular release;voltage;Work