ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Cancer;Chronic Pain;Clinical Research;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE Over half of all patients receiving taxane- or platinum-based chemotherapy for breast or gastrointestinal cancers experience a dose-limiting toxicity called chemotherapy-induced peripheral neuropathy (CIPN), which can involve numbness, tingling, pain, and sensitivity to cold in the hands and feet. There are few effective treatments for CIPN because the development of CIPN in humans is not well understood. This project will learn more about how the brain’s processing of bodily sensations might play a role in CIPN to inform new biomarkers and treatments for CIPN that will help alleviate the burden of chemotherapy on patients with cancer.

PI_NAMEs: KLECKNER, IAN ROBERT (contact)

PROGRAM_OFFICER_NAME: ACEVEDO, AMANDA MARIE

PROJECT_TERMS: Address;Affect;Age;Amyloid beta-Protein;Attention;Belief;Biological Markers;bodily sensation;Brain;brain magnetic resonance imaging;Breast;Breast Cancer therapy;C Fiber;Cancer Patient;cancer therapy;chemotherapy;Chemotherapy-induced peripheral neuropathy;Chemotherapy-Oncologic Procedure;Clinical;Clinical Trials;Communication;Data;Data Set;Detection;Development;Dose;Dose Limiting;Eating;effective therapy;Exercise;Exhibits;experience;FDA approved;Feeling;follow-up;foot;Functional disorder;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;gastrointestinal;Hand;Human;Impairment;innovation;insight;Insula of Reil;Interoception;Learning;Light;Longitudinal cohort study;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Measures;Meditation;mortality;MRI Scans;Muscle Cramp;Nervous System;neural;neurofilament;neurotoxic;novel;Numbness;observational cohort study;Pain;Patient Self-Report;Patients;Perception;Peripheral;peripheral nerve damage;Peripheral Nerves;Pharmaceutical Preparations;pharmacologic;Platinum;prophylactic;psychologic;Questionnaires;Reference Values;Reporting;Research;Rest;Role;Schedule;Serum;Severities;Sterile coverings;Symptoms;System;Tactile;taxane;Testing;theories;Time;time interval;Touch sensation;Toxic effect;Treatment-related toxicity;Walking;Work;Writing

PROJECT_TITLE: Longitudinal assessment of the role of interoception in chemotherapy-induced peripheral neuropathy (CIPN) along the cancer chemotherapy continuum

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE: Electrochemical generation of NO (E-NOgen) from simple inorganic nitrite using Cu(II)-ligand complexes is a completely new and promising technology to create NO on demand for inhaled NO (INO) treatments, use in oxygenators to prevent systemic inflammatory response syndrome (SIRS) during extracorporeal circulation, and to create novel antimicrobial/thromboresistant intravascular (IV) catheters. However, current Cu(II)-ligand catalysts are quite sensitive to dioxygen (O2), with increasing O2 levels leading to dramatically decreased NO generation rates. In the proposed research, completely new Cu(II)-ligand catalysts will be synthesized that greatly decrease the O2 sensitivity of the E-NOgen systems, and new materials and enzyme coatings will be developed that improve NO output (reducing loss of NO via reaction with O2 in the materials), enabling higher levels of NO production for a wide range of medical applications.

PI_NAMEs: LEHNERT, NICOLAI  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acceleration;Air;Animal Model;Anti-viral Agents;Antibiotic Resistance;antimicrobial;Area;Arteries;Attention;Bacteria;Bacterial Infections;Blood;Blood coagulation;carboxylate;catalyst;catheter related infection;Catheters;Chronic;Coagulation Process;Complex;Copper;cost;Cystic Fibrosis;Dedications;Devices;Diffusion;Dioxygen;Effectiveness;Electrodes;Elements;Enzymes;Extracorporeal Circulation;Family suidae;Fiber;fighting;Gases;Generations;glucose oxidase;Goals;Grant;Hospitals;Hydrogen Bonding;Hydrophobicity;Immobilization;improved;Infection;Infection prevention;infection risk;Inhalation;inhaled nitric oxide;Intensive Care;Ions;Leukocytes;Ligands;Local Anti-Infective Agents;Lung;lung failure;Lung Transplantation;Mediator;Medical;Medicine;Membrane;Methods;Microbial Biofilms;Neonatology;Nitric Oxide;Nitric Oxide Donors;Nitrites;Nitrogen;Nitrogen Dioxide;novel;Output;Oxidases;Oxidation-Reduction;Oxygenators;Patients;Performance;Phase;Physiological;Platelet Activation;Polyethylenes;Polymers;Porosity;portability;prevent;Prevention;Production;Publications;Pulmonary Hypertension;Reaction;Research;Respiratory Tract Infections;Risk Reduction;Safety;SARS-CoV-2 infection;scaffold;Sepsis;Sheep;sheep model;Silicones;Sinusitis;Stream;Surface;System;Systemic Inflammatory Response Syndrome;Technology;Testing;Therapeutic Uses;Thrombosis;Time;Tube;Tuberculosis;United States National Institutes of Health;Vasodilator Agents;Veins;voltage

PROJECT_TITLE: Optimization of Cu(II)-ligand catalysts, membrane materials, and coatings for O2-tolerant, portable, and low-cost electrochemical nitric oxide generation devices/catheters

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: The proposed research will integrate rigorous computational and experimental methods to study the transcriptional regulation of telomere-associated genes and immune checkpoint genes. The results of this research will help predict potential resistance mechanisms against therapies targeting the TERT promoter mutations that occur frequently in multiple cancer types and assist in developing effective combinatorial therapies.

PI_NAMEs: SONG, JUN S (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Acceleration;Address;Affinity;anti-PD-L1 therapy;Binding;biological adaptation to stress;Biological Response Modifiers;cancer cell;cancer type;Cell Cycle;Cell Physiology;combinatorial;Communication;Complex;Computer Analysis;computer framework;Data;detection of nutrient;dimer;Enhancers;Epigenetic Process;experimental analysis;Funding;Genes;Genetic Transcription;genome-wide;Goals;immune checkpoint;Immunologic Surveillance;Immunotherapy;improved;knowledge of results;Malignant Neoplasms;Mediating;Metabolic;Methods;Molecular;mutant;Mutate;Mutation;novel;novel strategies;overexpression;Pathway interactions;Pattern;Phenotype;Play;Precision therapeutics;predictive modeling;programmed cell death ligand 1;programs;promoter;Proteins;rapid technique;recruit;Recurrence;Regulation;Regulatory Element;Research;Resistance;resistance mechanism;response;RNA-Directed DNA Polymerase;Role;targeted treatment;Telomerase;telomere;Telomere Maintenance;Testing;TFE3 gene;Therapeutic;Therapeutic Intervention;therapeutically effective;transcription factor;transcription regulatory network;Transcriptional Regulation;treatment response;tumor;Work;YY1 Transcription Factor

PROJECT_TITLE: Predicting Transcriptional and Epigenetic Networks in Cancer from Sequencing Data

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The thermogenic beige adipocytes improve metabolic homeostasis by dissipating energy as heat. Our study focuses on gaps in understanding the mechanisms of induction and function of neonatal beige adipocytes. Given that neonatal beige adipocytes rejuvenate in adulthood, our study may lead to novel targets to induce beige adipocytes to improve metabolic health.

PI_NAMEs: RAMAKRISHNAN, SADEESH KUMAR  (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Ablation;Adipocytes;Adipose tissue;Adult;Attention;Binding Proteins;Cells;Characteristics;Child;ChIP-seq;Chromatin;Coenzyme A-Transferases;Data;Enzymes;Epigenetic Process;Family;Fatty acid glycerol esters;Gene Activation;Genes;Genetic Transcription;Glucose;Glycolysis Inhibition;HDAC3 gene;Health;Hepatic;Histone Deacetylase;Histone H3;Histones;Homeostasis;Impairment;improved;In Vitro;in vivo Model;insight;ketogenesis;ketogentic;Ketone Bodies;knock-down;Knock-out;Link;lipid biosynthesis;Liver;liver ablation;Mediating;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;Molecular;mouse model;Mus;Neonatal;neonate;nerve supply;novel;Obesity;Physiologic Thermoregulation;Physiological;Physiology;postnatal;pup;recruit;Rejuvenation;Repression;Role;Serum;Temperature;Testing;Thermogenesis;transcriptome sequencing

PROJECT_TITLE: Deciphering the physiology of neonatal beige adipocytes

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Narrative The ARIC neurocognitive cohort will now answer the compelling need to better understand risk of Alzheimer's dementia and Alzheimer's related dementias (AD/ADRD) among the oldest-old (85+ years) where current risk factors are not predictive. ARIC takes a comprehensive approach by studying a large diverse group of people from middle age to the oldest age with over three decades of rigorous data collection on every aspect of their lives. This renewal builds on very high productivity (245 papers since 2009) to continue rigorous data collection (proposed visits 11-13 accumulating 4732 dementia cases, half over age 85 by 2028) with a focus on blood biomarkers and outcomes across every aspect of aging.

PI_NAMEs: CORESH, JOSEF  (contact);MOSLEY, THOMAS H

PROGRAM_OFFICER_NAME: MONTASSER, MAY ESMAT

PROJECT_TERMS: Acceleration;Address;African American;African American population;Age;Aged, 80 and over;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Ancillary Study;apolipoprotein E-4;Attenuated;attenuation;Behavior;Biological Markers;Black race;Blood;Blood Vessels;blood-based biomarker;Brain Diseases;Brain imaging;Clinical;Cognition;Cognitive;cognitive function;cohort;Communities;Data;Data Collection;data sharing;Dementia;dementia risk;Diagnosis;Epidemiology;Evaluation;Event;Female;follow-up;frailty;Gait speed;Genetic Markers;genomic biomarker;Glial Fibrillary Acidic Protein;Hand Strength;Health;health equity;hearing impairment;Hospitalization;human old age (65+);human very old age (85+);Image;Impaired cognition;improved;innovation;K-Series Research Career Programs;late life;Life Cycle Stages;life span;Light;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;Metabolic Marker;middle age;mild cognitive impairment;modifiable risk;Modification;multimodality;multiple chronic conditions;Nerve Degeneration;Neurocognitive;neurofilament;novel marker;older adult;Older Population;Outcome;Paper;Participant;Pathology;Persons;Pharmaceutical Preparations;Phenotype;Physical Function;Physical Performance;Plasma;Population;Positron-Emission Tomography;predictive marker;Predictive Value;Prevention;Productivity;progression marker;Proteins;Proteomics;Publishing;Race;Research;Risk;Risk Factors;sex;Sleep;Sleep disturbances;social health determinants;Socioeconomic Status;socioeconomics;tau-1;vascular risk factor;Visit;Walking;Work

PROJECT_TITLE: ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Non-contact anterior cruciate ligament (ACL) injuries are accompanied by severe short- and long-term consequences, including early-onset osteoarthritis. The proposed research will identify kinematic and morphologic factors that are associated with elevated tension within the ACL functional bundles. Since elevated ACL tension reflects increased vulnerability to ligament failure, the proposed studies will provide crucial criteria that will identify those who are at high risk for injury and also enable targeted intervention strategies to those who are likely to benefit from injury prevention training.

PI_NAMEs: DEFRATE, LOUIS E. (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Age;Anterior Cruciate Ligament;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;Athletic;Biological;Body mass index;Characteristics;Clinical;Contralateral;Data;Deceleration;Degenerative polyarthritis;early onset;exhaustion;experience;Failure;Fatigue;Female;Femur;high risk;high risk population;imaging biomarker;in vivo;Injury;injury prevention;Intervention;Isotonic Exercise;kinematics;Knee;Knee Injuries;Knowledge;Lateral;Leg;Length;Ligaments;male;Measures;Mechanics;Methodology;Morphology;Motion;Movement;Multimodal Imaging;muscle strength;novel;Patients;Pattern;Protocols documentation;Race;Recording of previous events;Research;Risk;Risk Factors;Rotation;sex;Sports;Testing;three-dimensional modeling;Training;Translations;United States;women subjects

PROJECT_TITLE: In vivo ACL mechanics and risk factors for injury

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases;Lung

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Public Health Relevance Statement: Lung infections caused by Gram-negative `superbugs' is very difficult to treat due to the resistance to almost all current antibiotics except polymyxins. Inhaled polymyxin therapies have been increasingly used as the last resort globally; however, the lack of appropriate delivery system and dearth in pharmacological information have led to insufficient efficacy and pulmonary adverse effects. Our multi- disciplinary project will develop innovative aerosol delivery systems of polymyxin combinations with cutting-edge technologies to provide much safer and efficacious treatments for deadly Gram-negative lung infections.

PI_NAMEs: LI, JIAN ;ZHOU, QI  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: 3-Dimensional;Adverse effects;Aerosol Drug Therapy;Aerosols;alveolar epithelium;Amikacin;Aminoglycosides;Animals;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;antimicrobial;Apoptosis;Attenuated;attenuation;bacterial resistance;Biochemical Pathway;Cells;Cessation of life;Clinic;Clinical;Clinical Research;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Combating Antibiotic Resistant Bacteria;Combined Modality Therapy;dosage;Drug Exposure;Drug Interactions;Drug Kinetics;Drug resistance;Dryness;efficacious treatment;Electrostatics;Epithelial Cells;Epithelium;Evaluation;Exhibits;fine particles;Fluorescence Microscopy;Formulation;Freeze Drying;Future;Genes;Genomics;Gram-Negative Bacteria;Human;human data;Image;Imaging Techniques;improved;In Vitro;in vivo;Inhalation;Inhalation Therapy;innovation;interdisciplinary approach;Intravenous;Knowledge;Legal patent;Lung;Lung infections;Machine Learning;manufacture;Mediating;Microbial Biofilms;Mitochondria;Modeling;multidisciplinary;Multiple Bacterial Drug Resistance;multiple omics;Mus;National Institute of Allergy and Infectious Disease;Nebulizer;novel;Oxidative Stress;pathogen;Pathway interactions;Patient Compliance;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacotherapy;Plasmids;Polymyxin Resistance;Polymyxins;Powder dose form;Predisposition;prevent;Proteomics;public health relevance;Regimen;Reporting;Resistance;Resistance development;Roentgen Rays;Route;Superbug;Synchrotrons;System;Techniques;Technology;therapeutic target;therapeutically effective;Tissue Model;Tobramycin;Toxic effect;transcriptomics;Treatment Efficacy;uptake

PROJECT_TITLE: Aerosol delivery of combinational therapeutics targeting deadly lung infections

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Microbiome;Substance Misuse

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE The intestine and the liver are anatomically and physiologically connected, referred to as the gut-liver axis, which also plays a key role in the pathogenesis of several liver diseases. Here, scalable human gut-liver models containing primary cells will be developed for in vitro applications, such as compound screening and disease modeling, and be used to elucidate the effects of reciprocal tissue crosstalk on cell phenotype modulation.

PI_NAMEs: ALLBRITTON, NANCY L.;KHETANI, SALMAN R (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: 3-Dimensional;Affect;alcohol effect;Alcohol Nutrition;Alcoholic Liver Diseases;Anatomy;Animals;Anti-Inflammatory Agents;Basic Science;Bile fluid;Biological Assay;Cell Compartmentation;Cell Differentiation process;cell type;Cells;Chemicals;Cirrhosis;Clinical;Coculture Techniques;Coupled;Custom;Cytochrome P450;design;Development;Disease;disease model;Drug Screening;drug testing;Endothelial Cells;Engineering;enzyme activity;Epithelium;experimental study;Extracellular Matrix;fatty liver disease;Flushing;Future;Gases;Gel;Growth;gut microbiota;Gut Mucosa;gut-liver axis;Hepatic;Hepatic Stellate Cell;Hepatocyte;high reward;high risk;Hour;Human;human model;In Vitro;in vitro Model;in vivo;Individual;Industrialization;intestinal barrier;Intestinal permeability;Intestines;Kupffer Cells;Liver;Liver diseases;Measures;Metabolic;metabolic-associated fatty liver disease;microbiome;microbiome composition;microbiota;Microfluidics;Modeling;Molecular;Mucous body substance;Organ;Outcome;Overnutrition;Oxygen;pathogen;Pathogenesis;Pathology;Pattern;pharmacologic;Phenotype;Physiological;Physiology;Play;Portal vein structure;problem drinker;Research;Research Personnel;Resources;Rodent;Role;screening;self assembly;Sensitivity and Specificity;spheroids;stem cells;Surface;Technology;Time;Tissues;Toxicology;transcriptome;transcriptome sequencing;Xenobiotic Metabolism

PROJECT_TITLE: A Human Gut-Liver Platform with Microbiome Interactions for In Vitro Toxicology

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: NARRATIVE Polymicrobial infections are an increasing concern for human health. In this project, we will study the inter- kingdom interaction between the pathogen Salmonella enterica serovar Typhimurium (STm) and the opportunistic pathogenic yeast Candida albicans in the gut. We will analyze direct microbe-microbe, as well as immune mediated mechanisms that lead to a blunted immune response, higher weight loss and higher STm dissemination in mice during co-infection.

PI_NAMEs: BEHNSEN, JUDITH  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Adult;Antibiotic Resistance;Bacteria;Bacterial Adhesins;Binding;Body Weight decreased;Candida;Candida albicans;Cecum;Cell surface;Cells;Clinical Research;co-infection;Coculture Techniques;Colon;Crohn's disease;cytokine;Data;dectin 1;Disease;disease model;Epithelial Cells;Epithelium;Etiology;Exhibits;Farnesol;foodborne;Fungal Components;fungal microbiota;fungus;Gastroenteritis;gastrointestinal;Gene Expression;Genes;Glucans;Gnotobiotic;Goals;gut inflammation;gut microbiome;Health;Human;Hyphae;Immune;immune cell infiltrate;Immune response;immunological status;immunoregulation;In Vitro;in vivo;Infection;Inflammatory;Inflammatory Response;Invaded;Liver;Macrophage;Mediating;Microbe;microbial;microbiome components;microbiome composition;Microscopy;Modeling;mortality;mouse model;Mus;Parasites;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Patients;Persons;Phagocytosis;polymicrobial biofilm;Process;Proteins;quorum sensing;receptor;response;Role;Salmonella enterica;Salmonella infections;Salmonella paratyphi;Salmonella typhi;Salmonella typhimurium;Severity of illness;Signaling Molecule;Spleen;Systemic infection;Testing;Toxin;transcriptome sequencing;Virulence;virulence gene;Virus;Yeasts

PROJECT_TITLE: Inter-kingdom interactions of Salmonella Typhimurium and Candida albicans in the gut

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IMII-U (01)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: MINNEAPOLIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative: This proposed work is relevant to public health because it develops a novel high-throughput method for extracting valuable information from metagenomic data, with a focus on critical antimicrobial resistance genes and the pathogens that harbor them. This contribution is significant because it will enable improved clinical and public health decisions regarding antibiotic use and interventions to break transmission of antimicrobial resistant pathogens. The outcomes of the work therefore support NIH's mission to reduce morbidity and mortality by combating antimicrobial resistance.

PI_NAMEs: NOYES, NOELLE  (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Adopted;Algorithms;Antibiotics;antimicrobial;Antimicrobial Resistance;antimicrobial resistant infection;antimicrobial resistant pathogen;Applied Research;Bacteria;bacterial community;Base Sequence;Basic Science;Biological Assay;Cessation of life;Characteristics;Classification;Clinical;clinical application;Color;combat;Communities;Complex;cost;Custom;Data;deep sequencing;design;direct application;DNA;Ecology;Environment;Event;Generations;Genes;Genome;Genomics;Goals;Graph;health application;Healthcare;heuristics;Hospitals;improved;In Situ;Incidence;indexing;innovation;Intervention;Knowledge;Knowledge Discovery;manufacture;metagenomic sequencing;Metagenomics;Methodology;Methods;microbial;microbial community;microbiome;microbiome research;Mission;Modern Medicine;Molecular;Morbidity - disease rate;mortality;nanopore;novel;Outcome;pathogen;Patient-Focused Outcomes;Patients;Performance;Phenotype;Population;prevent;programs;Public Health;Public Health Applications Research;Research;Resistance;Resistance development;resistance gene;resistome;Role;Sampling;Scientific Advances and Accomplishments;Sensitivity and Specificity;Time;transmission process;United States National Institutes of Health;Work

PROJECT_TITLE: Triple-enriched metagenomics for robust resistome analysis

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Cellular response and adaptation to stress is a fundamental aspect of normal tissue homeostasis, and in cancer, cellular adaptation manifests detrimentally as cancer cell resistance to therapy. This project addresses the current lack of methods for multiome single-cell and spatial fate tracking and computational cell fate prediction in systems where cell population dynamics are shaped by survival and adaptation. The proposed experimental and computational methods are generally applicable to the study of time-dependent cellular processes in biology and medicine, and the data generated will advance our understanding of drug resistance in cancer.

PI_NAMEs: SHAFFER, SYDNEY ;ZHANG, NANCY R (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Adoption;analysis pipeline;ATAC-seq;Automobile Driving;Bar Codes;biological adaptation to stress;biological systems;Biology;cancer cell;Cell Death;Cell Differentiation process;Cell Line;Cell Lineage;Cell Physiology;Cell Survival;cell type;Cells;Cellular Stress;Cessation of life;Clinical;Communities;Complex;computational pipelines;computer framework;Computer software;computerized tools;Computing Methodologies;CRISPR/Cas technology;Data;data analysis pipeline;Development;Disease;DNA Sequence;Drug resistance;Drug Targeting;Epigenetic Process;Experimental Genetics;experimental study;Exposure to;fascinate;Genetic;Genetic Transcription;Goals;Growth;Heterogeneity;Homeostasis;Human;human disease;In Situ;in vivo;Individual;interest;Label;Learning;Malignant Neoplasms;Medicine;method development;Methods;multimodality;Multiomic Data;multiple omics;Mutate;neoplastic cell;new technology;Normal tissue morphology;novel;open source;Outcome;Patients;Pharmaceutical Preparations;Population;Population Dynamics;Procedures;Process;Proliferating;Protocols documentation;reconstruction;Resistance;Resolution;response;RNA;Role;Sampling;senescence;Shapes;Signal Transduction;single cell sequencing;single cell technology;Site;Source;Stress;stressor;System;Techniques;Technology;Testing;therapy resistant;Time;Time Study;Tissues;tool;transcription factor;transcriptome sequencing;transcriptomic profiling;transcriptomics;trend;tumor;Validation;Variant;Work;XCL1 gene

PROJECT_TITLE: Multiomic single cell and spatial interrogation of mechanisms in cellular adaptation to stress


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_DEPT: NEUROLOGY

PHR: Project Narrative The primary goals of this project are to understand the network brain activity that underlie slowness of movement (bradykinesia) in Parkinson's disease and to identify specific neural pathways associated with improved bradykinesia via deep brain stimulation (DBS). Specifically, we look to describe the pathophysiological activity in the pallidum and pallido-motor cortex (M1) network that are associated with slowness of movement (bradykinesia), a cardinal sign of PD, their spatial topography within the internal segment of the globus pallidus (GPi) and to identify activation of pallidothalamic pathways through coherence- based directional deep brain stimulation, which results in improved bradykinesia. Data from this project will provide the rationale for targeting substructures and/or pathways within or around GPi for patient-specific, physiologically-based stimulation and for the development of closed-loop stimulation paradigms.

PI_NAMEs: AMAN, JOSHUA E (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Acceleration;Algorithms;awake;Axon;Basal Ganglia;Biological Markers;biomarker identification;biophysical model;Biophysics;Bradykinesia;Brain;Characteristics;Clinical;Computer Models;Data;Deep Brain Stimulation;Development;disability;Dorsal;education pathway;effective therapy;Electrocorticogram;Exhibits;Follow-Up Studies;Frequencies;Globus Pallidus;Goals;High Frequency Oscillation;high resolution imaging;Image;Implant;improved;Independent Living;individualized medicine;innovation;Lateral;Lead;Location;Measures;meetings;Microelectrodes;Modeling;Motor;Motor Cortex;motor function improvement;Motor Pathways;Movement;neural;Neural Pathways;neurophysiology;novel;Operating Rooms;Operative Surgical Procedures;Outcome;Parkinson Disease;participant enrollment;Pathway interactions;Patients;Physiological;Play;Positioning Attribute;Postoperative Period;potential biomarker;Preparation;Reporting;Resolution;Rest;Role;Severities;Site;Spatial Distribution;Technology;Thalamic structure;Time;tool

PROJECT_TITLE: Characterizing the pathophysiological role of the pallido-thalamocortical motor pathway in Parkinson's disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: A more durable vaccine for respiratory viral pathogens, including SARS COV2 and influenza, is the long term goal of many laboratories. We have discovered a novel population of CD8 T cells in mice vaccinated through skin with MVA vectors that respond rapidly and efficiently to viral infection and challenge of lung without compromising lung parenchymal space. Our goal is to fully understand how these cells are generated, how they interact with lung vasculature, and how to enhance their protective capacity, in order to devise the best approach for reproducibly preventing morbidity and mortality after lung viral infection.

PI_NAMEs: KUPPER, THOMAS S. (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: 2019-nCoV;absorption;Acute;adhesion process;Alveolus;anti-CD20;Antibodies;Antigens;Area;ATAC-seq;B-Lymphocytes;Behavior;Biological;Blood;Blood capillaries;Blood Vessels;Carbon Dioxide;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular biology;Cessation of life;combat;Cross Presentation;Dedications;Dermis;design;Dimensions;economic cost;Environment;Epigenetic Process;Epithelium;Epitopes;Excretory function;Extravasation;Flow Cytometry;Gases;Gastrointestinal tract structure;Gene Expression Profile;Generations;Genetic Models;Genetic Transcription;Goals;Grant;Half-Life;Hour;Human;Immediate-Early Genes;Immune;Immunity;Immunization;Immunize;Immunologic Memory;improved;in vivo;Infection;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;interest;Intramuscular;Intravenous;intravital microscopy;Kinetics;Laboratories;Light;Lung;Lung infections;Measures;Mediating;Memory;Modeling;Modified Vaccinia Virus Ankara;Morbidity - disease rate;mortality;Mucous Membrane;Mus;Nature;neutralizing antibody;novel;Oral;Organ;pandemic disease;pathogen;pathogenic virus;Peripheral;Phenotype;Population;poxvirus vectors;preservation;prevent;Property;Proteins;Pulmonary Challenge;pulmonary function;Reproducibility;reproductive;Research Personnel;respiratory;respiratory pathogen;response;single-cell RNA sequencing;Skin;Skin Tissue;skin vaccination;Spleen;Structure of parenchyma of lung;T cell response;T memory cell;T-Lymphocyte;TCR Activation;Technology;Testing;Time;tissue resident memory T cell;Tissues;Transgenic Mice;Transgenic Model;Vaccinated;Vaccination;Vaccines;vector;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases;Writing

PROJECT_TITLE: Skin vaccination and generation of protective lung-tropic memory T cells

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Pancreatic cancer is the second leading cause of cancer-related death, with less than 5% survival after 5 years; although patients succumb to metastases, there are no specific diagnostic markers or therapeutic strategies aimed at treating metastases, particularly due to an almost complete lack of knowledge on the molecular drivers of metastatic progression. Using a combination of comparative transcriptomics and a novel functional screen, we identified a novel metabolic pathway (that includes an aminoacid transporter and a conjugating enzyme) in metastatic lesions, which inhibition completely halted the growth of metastases without affecting the primary tumors; furthermore, preliminary data indicate that they may provide metabolic fitness for metastatic cells to grow in these foreign niches, indicating that these lesions evolve by acquiring non-genetic adaptations. In this proposal, we will take advantage of biochemistry, cell biology, mouse models and samples from human patients in order to molecularly characterize this pathway, with the potential to change treatment for this devastating disease.

PI_NAMEs: MOSTOSLAVSKY, RAUL  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Ablation;Affect;Agar;Amino Acid Transport System A;Amino Acid Transporter;Amino Acids;ATAC-seq;Automobile Driving;Autopsy;Biochemical;Biochemistry;Biological Assay;cancer cell;Cancer Etiology;cancer heterogeneity;cell community;Cells;Cellular Assay;Cellular biology;Cessation of life;Chromatin;chromatin modification;comparative;Coupled;Cysteine;Data;diagnostic biomarker;digital;Disease;Disease Progression;Doxycycline;driver mutation;Drug Metabolic Detoxication;Enzymes;Epigenetic Process;epigenomics;Extracellular Matrix;Extracellular Matrix Proteins;Fibronectins;fitness;Foundations;Future;Gene Deletion;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;genetic manipulation;Genetic Transcription;Genetically Engineered Mouse;Genomics;Glutathione;Glutathione S-Transferase;Growth;Hepatocyte;Heterogeneity;Human;in vivo;insight;Knock-out;Knowledge;Label;Lesion;Link;Liver;lung metastatic;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;Metabolic;metabolic fitness;Metabolic Pathway;metabolomics;Molecular;mouse model;Neoplasm Metastasis;Nodule;non-genetic;novel;Nutrient;overexpression;Oxidative Stress;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;Phenotype;Population;Primary Neoplasm;programs;Proliferating;Protein Secretion;Proteins;Reporter;repository;Resolution;Role;Sampling;Serine;Shapes;Specimen;System;Therapeutic;Tissue-Specific Gene Expression;Tissues;transcription factor;transcriptome sequencing;transcriptomics;Transplantation;tumor growth;Up-Regulation;uptake;validation studies

PROJECT_TITLE: A novel, glutathione-dependent metabolic pathway drives metastatic outgrowth in pancreatic cancer

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eczema / Atopic Dermatitis;Pediatric;Prevention

ORG_CITY: PORTLAND

ORG_DEPT: DERMATOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Decentralized clinical trials are a new form of clinical study designed to expand access to studies and reduce the burden on study participants by using technology, such as mobile phones, to collect data from home. This study creates a new way to identify new onset atopic dermatitis (eczema) and grade the severity of the skin condition using a mobile phone by parents or guardians. This will allow a more patient-centered approach to testing the best ways to treat and prevent eczema and allergies – a significant global health problem.

PI_NAMEs: SIMPSON, ERIC L (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 5 year old;Address;Affect;Age;Area;Asthma;Atopic Dermatitis;Cellular Phone;Child;Childhood;chronic inflammatory disease;Clinic;Clinical Research;Clinical Trials;Clinical Trials Network;cohort;Collaborations;Communities;community setting;comorbidity;COVID-19 pandemic;Data;Decentralization;Dermatologist;Dermatology;Development;diagnostic criteria;disability burden;Disease;Disease remission;Documentation;Early Diagnosis;Early Intervention;Early intervention trials;early onset;Eczema;Enrollment;Ensure;Exanthema;experience;Family;Food Hypersensitivity;Future;Genetic;global health;Goals;high risk;Home;Hybrids;Hypersensitivity;Image;Immunologics;improved;indexing;Infectious Skin Diseases;Infrastructure;International;Intervention;Life;Longitudinal Studies;Measurement;Measures;mobile application;Neurodevelopmental Disorder;novel;Outcome;Outpatients;Parents;Participant;patient oriented;Patients;Pediatric cohort;Persons;Photography;prevent;Questionnaires;Recording of previous events;recruit;Report (document);Reporting;Research;Research Design;Research Personnel;Research Priority;Risk;Role;Secure;Severities;Severity of illness;Skin;skin barrier;skin lesion;Software Engineering;Standardization;success;Technology;Testing;Therapeutic;Therapeutic Intervention;Time;tool;Vendor;virtual

PROJECT_TITLE: Parent-directed remote identification and severity assessments enabling decentralized trials in atopic dermatitis

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_DEPT: PSYCHOLOGY

ORG_NAME: HUNTER COLLEGE

PHR: Project Narrative/Relevance Statement Chronic social defeat stress, a rodent paradigm widely used for investigating the effects of stress on circuits underlying mood and anxiety disorders, reliably leads to deficits in social interaction. This project addresses the role of fear circuits in mediating stress-induced social avoidance by targeting 1) amygdala input to the nucleus accumbens, 2) prelimbic input to the amygdala, and 3) by characterizing dynamic patterns of neural activity between all three regions. The findings have the potential to significantly broaden our current understanding of how chronic exposure to a social stressor modulates networks mediating learned social behavior.

PI_NAMEs: BURGHARDT, NESHA STAR (contact);LIKHTIK, EKATERINA

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Address;Affect;American;Amygdaloid structure;Animals;Anxiety;Anxiety Disorders;avoidance behavior;Avoidance Learning;Behavior;behavioral response;Brain region;Cell Nucleus;Cells;Chronic;Chronic stress;clinically relevant;Communication;comorbidity;Coping Skills;Data;depressed patient;Disease;experimental study;Exposure to;fear memory;Fright;Future;Genetic;genetic manipulation;in vivo;Individual;innovation;Learning;Literature;Maps;Medial;Mediating;memory retrieval;Mental Depression;Mental disorders;Methodology;Methods;Mood Disorders;Motivation;Mus;neural;neural patterning;neurophysiology;novel;Nucleus Accumbens;Pathway interactions;Patients;Physiology;Post-Traumatic Stress Disorders;Predisposition;Prefrontal Cortex;Regulation;response;Retrieval;reward circuitry;Rewards;Risk Factors;Risk Reduction;Rodent;Rodent Model;Role;Route;sex;Site;social;Social Anxiety Disorder;Social Behavior;social defeat;social engagement;Social Interaction;social learning;social stressor;Socialization;Stress;stress reduction;stressor;System;Testing;Time;Ventral Tegmental Area;Work

PROJECT_TITLE: Circuit-level regulation of social avoidance learning in chronically stressed mice

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Radiation Oncology

ORG_CITY: BIRMINGHAM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Radiotherapy (RT) induces a wide array of immunomodulating effects and offers an “ideal” therapeutic option to overcome therapeutic resistance to anti-CTLA-4 and anti-PD-1/L1, a significant unmet medical need. This project is designed to identify heretofore unknown T cell-intrinsic mechanisms underlying RT and then exploit them (+RT) to overcome immunotherapeutic resistance.

PI_NAMEs: SHI, LEWIS ZHICHANG (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Acetates;Acetyl Coenzyme A;Adjuvant;anti-CTLA4;anti-PD-1;anti-PD1 therapy;anti-tumor immune response;Area;bench-to-bedside translation;Bypass;cancer care;cancer infiltrating T cells;cancer type;Cell Maturation;chemotherapy;Clinical;Clinical Trials;Clinical Trials Design;clinically relevant;combinatorial;Complex;Cross-Priming;cytotoxicity;Data;Databases;Dendritic Cells;design;Dose;drug repurposing;Equilibrium;Eragrostis;FDA approved;Fractionation;FRAP1 gene;Future;gain of function;Genetic;Glycolysis;Goals;HMGB1 gene;Human;Hypoxia Inducible Factor;immune activation;immune checkpoint blockers;Immune response;Immune system;immunogenic;Immunologics;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In Situ;inhibitor;interest;Interferons;JAK1 gene;Malignant Neoplasms;Mediating;Medical;Melanoma;Metabolic;Metabolic Control;metabolic fitness;Mining;Molecular;Mus;neoantigens;neoplastic cell;novel;novel therapeutics;Oxidation-Reduction;Pathway interactions;Patients;pharmacologic;Process;Production;programs;Publishing;Radiation therapy;rational design;Regimen;Regulatory T-Lymphocyte;Reporting;Resistance;resistance mechanism;Role;Sampling;Seminal;Shapes;Signal Transduction;STAT3 gene;Stimulator of Interferon Genes;success;Supplementation;System;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;therapy resistant;Time;Treatment Efficacy;tumor;Tumor Debulking;Tumor Immunity;Tumor Suppression;Vaccines

PROJECT_TITLE: T cell-intrinsic metabolic control of radiotherapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Clinical Research;Food Allergies

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE IgE is an antibody produced by B cells in people with food allergies and asthma, and it can cause life-threatening anaphylaxis, especially in those with food allergy. We discovered a new type of T cell that promotes B cell production of IgE, but we do not know how the signals from this T cell control the IgE B cell response. Our lab developed the techniques necessary to discover these molecular pathways in human and mouse B cells that promote anaphylaxis-inducing IgE.

PI_NAMEs: EISENBARTH, STEPHANIE CAROLINE (contact);WILLIAMS, ADAM

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Ablation;Acute;Affinity;Allergens;Allergic;Allergic Disease;allergic response;Anaphylaxis;Antibodies;Antibody Response;Antigens;Asthma;Automobile Driving;B cell differentiation;B-Lymphocyte Subsets;B-Lymphocytes;Blocking Antibodies;Cell Communication;Cell Culture System;Cell Lineage;Cell Physiology;Cell Survival;Cells;ChIP-seq;Confocal Microscopy;crosslink;cytokine;Data;Developed Countries;Environmental Risk Factor;Equilibrium;Exposure to;food allergen;Food Hypersensitivity;Genetic;glycosylation;Helper-Inducer T-Lymphocyte;Human;Hypersensitivity;IgE;IgG1;IL4 Signaling Pathway;Image;Immune;Immunofluorescence Immunologic;Immunoglobulin Class Switching;Immunoglobulin M;Immunologics;Impairment;In Vitro;in vivo;Inhalation;inhibitor;Interleukin 4 Receptor;Interleukin-13;interleukin-13 receptor;interleukin-21;Interleukin-4;Knock-out;Knockout Mice;Life;Longevity;lymph nodes;Mass Spectrum Analysis;mast cell;Mediating;Molecular;Mus;novel;Pathologic;Pathway interactions;Patients;Persons;PIK3CG gene;plasma cell differentiation;Plasma Cells;Plasmablast;prevent;Production;Proteomics;rational design;Reaction;receptor;Receptor Signaling;Regional Anatomy;Regulation;Resolution;response;Role;sialylation;Signal Pathway;Signal Transduction;STAT6 gene;Structure of germinal center of lymph node;Surface;System;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;Therapeutic Intervention;transcriptome sequencing;transcriptomics;Uncertainty;Work

PROJECT_TITLE: Immune Mechanisms Regulating Allergy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-B (57)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Alzheimer's disease (AD) is the most common dementia characterized by progressive cognitive decline, and there are obstacles prevent the development of new therapeutic strategies and their translation to human patients. This proposal is based upon analysis of human AD cases and animal models, as it bridges multiple aspects of AD pathology: discovery of unique oxidative stress pathway, new aspects of microglial biology and dysfunction, and basic mechanisms of cell adhesion/phagocytosis in the context of disease. We will answer how exactly oxidation causes microglial dysfunction in AD and how to prevent/inhibit their detrimental consequences in AD.

PI_NAMEs: BYZOVA, TATIANA V (contact);PODREZ, EUGENE A

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Adhesions;Affect;Age related macular degeneration;age-related disease;Aldehydes;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Amyloid beta-Protein;Animal Model;Biology;Brain;brain tissue;Cell Adhesion;Cell Separation;Chemicals;Complex;Dementia;design;Development;Disease;Disease Progression;Economic Burden;Event;Exposure to;fatty acid oxidation;Functional disorder;Gliosis;Human;human disease;Human Pathology;Impaired cognition;In Vitro;in vivo;Integrin-mediated Cell Adhesion Pathway;Intervention;Lead;Leukocyte Adhesion Deficiency;Ligands;Link;Lipid Peroxidation;Lipids;Membrane;Membrane Proteins;Methods;Microglia;migration;Modeling;Modification;Molecular;Monitor;mouse model;Mus;Mutate;Mutation;Myeloid Cells;Nerve Degeneration;Neurodegenerative Disorders;novel;novel therapeutic intervention;novel therapeutics;Outcome;oxidation;oxidative damage;Oxidative Stress;Oxidative Stress Pathway;Pathologic;Pathology;Pathway interactions;Patients;Phagocytosis;Polyunsaturated Fatty Acids;Population;Post-Translational Protein Processing;preservation;prevent;Prevention;Process;protein function;protein structure;Proteins;Proteomics;receptor;Reporting;Role;Site;socioeconomics;Specimen;superoxide dismutase 1;System;Technology;translation to humans;vesicle transport

PROJECT_TITLE: Novel oxidative pathway targets microglia in Alzheimer's disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Narrative This project will determine how several multi-protein complexes and other proteins together produce functional messenger RNAs for the cellular energy generating machinery of important parasites by changing the mRNA information content after synthesis from DNA and do so differentially in parasites in humans versus in the transmitting insect. The research may aid development of drugs for multiple pathogens and provide insights into the functions of proteins that have important roles in controlling the utilization of information encoded in RNA or DNA in higher organisms, including humans.

PI_NAMEs: STUART, KENNETH D (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Affect;Affinity Chromatography;Amino Acids;Binding;Blood Circulation;Catalytic Domain;Cells;Characteristics;Chemicals;Complex;crosslink;Data;deep sequencing;Dependence;Development;DNA;DNA biosynthesis;drug development;Drug Targeting;Electron Transport;endonuclease;Enzymes;Equipment and supply inventories;Eukaryota;Goals;Guide RNA;HTATIP2 gene;Human;Immunoprecipitation;in vivo;Insecta;insertion/deletion mutation;insight;Knock-in;Label;Life Cycle Stages;Link;loss of function mutation;Messenger RNA;Methods;Mitochondria;Mitochondrial DNA;mitochondrial messenger RNA;Modeling;Molecular Conformation;Multiprotein Complexes;Mutagenesis;mutant;Mutation;Mutation Analysis;mutation screening;new therapeutic target;Nucleic Acids;Organism;Parasites;pathogen;Post-Translational Protein Processing;practical application;Process;Property;protein complex;protein crosslink;protein function;Proteins;Regulation;Research;Reverse Transcriptase Polymerase Chain Reaction;RNA;RNA Editing;RNA Processing;RNA-Protein Interaction;Role;Site;Structural Models;Structure;System;Tertiary Protein Structure;Testing;transmission process;Trypanosoma;Trypanosoma brucei brucei;vector;Visualization

PROJECT_TITLE: Mitochondrial DNA of Normal and Mutant Trypanosomes

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE (RELEVANCE) The proposed research is directly related to public health because understanding the mechanisms of small cell lung cancer initiation and progression is expected to give rise to new types of diagnoses, treatments, and preventions for small cell lung cancer. Thus, this study is relevant to the part of NIH’s mission that pertains to fostering fundamental creative discoveries and innovative research strategies as a basis for ultimately protecting health.

PI_NAMEs: PARK, JAE-IL  (contact);PARK, KWON-SIK

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Ablation;Acceleration;Actins;Antigen Presentation;Antigen Presentation Pathway;Binding Proteins;Biological Models;Biology;biomarker discovery;cancer genomics;cancer initiation;Cancer Patient;Cell Lineage;Cells;Chemotherapy and/or radiation;Chromatin;chromatin remodeling;Clinical;Collaborations;Complex;conditionally replicative adenovirus;Creativeness;Development;Diagnosis;Disease;Effectiveness;Engineering;Epigenetic Process;Epithelial Cells;experimental study;Extensive Stage;Fostering;Foundations;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genetically Engineered Mouse;Goals;Group Meetings;Health protection;Human Resources;Hyperplasia;Image;immune checkpoint blockade;Immunotherapy;Impairment;innovation;innovative technologies;insight;Intervention;Investigation;Knock-out;Knockout Mice;Knowledge;Laboratories;loss of function mutation;Lung;Malignant - descriptor;Malignant Neoplasms;Microscopy;Mission;Modeling;Molecular;Molecular Profiling;mouse model;Mus;Mutate;Mutation;Neoplasms;neoplastic;Neuroendocrine Cell;Neurosecretory Systems;novel;Nuclear;patient derived xenograft model;patient stratification;Persons;Play;polymerization;Polymers;predicting response;Prevention;Proteins;Public Health;RB1 gene;Recurrence;Research;response;Role;small cell lung carcinoma;Solid;System;targeted treatment;Testing;therapy development;TP53 gene;transcriptome;transcriptomics;tumor;tumor initiation;Tumor Markers;tumor progression;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;United States National Institutes of Health;Universities;Virginia;virtual

PROJECT_TITLE: CRACD-controlled cell plasticity and small cell lung cancer

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative Parents require skills to initiate and sustain protective family communication about sexuality and health with gay, bisexual, or queer (GBQ) male adolescents. The proposed study is relevant to public health as it is centered on helping parents answer and meet the sexuality-specific questions and needs of GBQ youth after they disclose sexual orientation. This study seeks to test the efficacy of Parents ASSIST as a parent-child sexuality communication intervention that educates and trains parents to be purveyors of inclusive health information as GBQ sons come of age at home.

PI_NAMEs: FLORES, DALMACIO DENNIS (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: acceptability and feasibility;Address;Adolescence;Adolescent;adolescent health;Affect;Affective;Age;Anxiety;anxiety symptoms;arm;Asian Americans;Attention;Attitude;Behavior;Behavioral Model;Belief;Bisexual;Black race;Child;children of color;cisgender;Color;Communication;comparison control;Control Groups;Country;depressive symptoms;Disclosure;Distal;Education;Educational workshop;efficacy testing;ethnic minority;Ethnic Origin;Event;evidence base;Family;Family health status;Family Relationship;Fathers;follow-up;Fortification;Fostering;Frequencies;Gays;Gender;gender minority group;gender minority youth;Generations;Health;Health behavior;health disparity;Health Promotion;health seeking behavior;Health Services;Home;Hybrids;improved;Individual;innovation;Interruption;Intervention;intervention effect;late life;Latinx;Learning;Lesbian Gay Bisexual Transgender Queer;Life;long-standing disparities;male;Male Adolescents;Mediating;member;Mental Depression;Mental Health;Mental Health Services;Methods;minority health;online intervention;Outcome;parental role;parenting intervention;Parents;Participant;Personal Satisfaction;physical health service;Play;preference;Preventive Health Services;Process;programs;protective factors;Public Health;queer;Race;racial minority;Randomized;Randomized, Controlled Trials;recruit;Recurrence;Reporting;Research;response;Sampling;Schools;screening;Self Efficacy;Series;sex;Sex Education;Sex Orientation;sexual minority group;sexual minority male;sexual minority youth;Sexuality;skills;social media;Son;Statutes and Laws;synchronous contact;Teenagers;Testing;theories;Time;trend;Voice;Work;Youth

PROJECT_TITLE: Intervention to improve parent communication about sexuality with sexual minority male adolescents

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: MD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: ATLANTA

ORG_NAME: CLARK ATLANTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The incidence of prostate cancer is 1.6, and the mortality rate is 2.5 times higher in African-American men when compared to Caucasian men. The reasons for this increased risk for African-American men are multifactorial social, behavioral, economical, and systemic differences that result in biological tranformities leading to cancer. Combined strategies based on biomedical research, social/behavioral investigations and community engagement are required to combat this disease in the African-American community, and the Center for Cancer Research and Therapeutic Development (CCRTD) at Clark Atlanta University (CAU) is focused on the trilateral approaches to conduct basic research in prostate cancer, train the next generation of scientists in prostate cancer and build trust in the African-American community through engagement, education, outreach, and culturally- sensitive dissemination of our research agenda.

PI_NAMEs: KHAN, SHAFIQ A (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Accreditation;Affect;African American;African American student;anti-cancer research;Architecture;Award;Awareness;Basic Science;Behavior;Behavioral;behavioral and social science;Behavioral Research;Biological;Biological Sciences;Biomedical Research;Black American;Caliber;Cancer Biology;cancer therapy;Caucasians;Chemistry;Cities;college;combat;Communities;community engagement;Community Health Education;Community Outreach;Core Facility;Data;Data Storage and Retrieval;Death Rate;Decision Making;Dedications;Development;Disease;drug discovery;Early Diagnosis;Early treatment;Education;Education and Outreach;Equipment;Equity;Ethnic Origin;Faculty;Faculty Recruitment;Family;Future Generations;Graduate Degree;graduate student;Health Disparities Research;higher education;Historically Black Colleges and Universities;improved;Incidence;Infrastructure;Institution;interest;International;Investigation;Laboratories;Lateral;Malignant neoplasm of prostate;Malignant Neoplasms;member;men;Modernization;NCI Center for Cancer Research;next generation;Outcome;outreach;outreach program;Parents;Pilot Projects;Population;Postdoctoral Fellow;Prevention;Privatization;Process;programs;racial diversity;recruit;Research;Research Activity;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Research Training;Risk;Schools;Science;Scientist;social;Social Work;socioeconomics;Students;Teacher Professional Development;tenure track;Therapeutic;therapeutic development;Training;Training and Education;translational approach;Translational Research;Trust;undergraduate student;United States National Institutes of Health;Universities

PROJECT_TITLE: Enhancement of Cancer Research at Clark Atlanta University

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 ML (A1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Prostate Cancer;Urologic Diseases

PI_NAMEs: HINTON DIRICKSON, CIMONA VAUGHN (contact)

PROJECT_TERMS: Accountability;Address;Adherence;advanced prostate cancer;Advisory Committees;African American;anti-cancer research;Area;Award;behavioral health;Behavioral Research;Biomedical Research;cancer health disparity;Cancer Research Project;Charge;Collaborations;Communication;Communities;community engagement;Crystallization;design;Development;Development Plans;Educational workshop;Evaluation;Extramural Activities;Faculty;Faculty Recruitment;Funding;General Population;Goals;Grant;Health;Health Disparities Research;Human Resources;Infrastructure;innovation;Institution;interest;Leadership;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;member;men;Mentors;Mentorship;Mission;Monitor;National Institute on Minority Health and Health Disparities;NCI Center for Cancer Research;Occupational activity of managing finances;Office of Administrative Management;Output;Participant;Pilot Projects;Postdoctoral Fellow;Preparation;Principal Investigator;Productivity;Program Evaluation;programs;recruit;Reporting;Research;Research Activity;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response;Scientist;Series;Services;social;Students;success;symposium;Technology;therapeutic development;Translating;United States National Institutes of Health;Universities;University adminstration

PROJECT_TITLE: ADMINISTRATIVE CORE


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Social Determinants of Health;Urologic Diseases

PI_NAMEs: ALHASSAN, MUSTAPHA  (contact)

PROJECT_TERMS: Address;Advocacy;African American;anti-cancer research;Area;Award;Behavioral Research;Biological;Biomedical Research;cancer education;cancer health disparity;cancer therapy;combat;Communities;community academic partnership;community advisory board;community collaboration;community engagement;community partners;Creativeness;Disease;Education;Educational process of instructing;Focus Groups;Fostering;Goals;Health;health disparity;improved;Incidence;Knowledge;Learning;Malignant neoplasm of prostate;member;men;metropolitan;mortality;NCI Center for Cancer Research;outreach;Participant;programs;prostate cancer prevention;Radio;Research;research and development;research in practice;Research Project Grants;Scientist;Series;Services;social;socioeconomics;therapeutic development;Universities

PROJECT_TITLE: COMMUNITY ENGAGEMENT CORE


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Prostate Cancer;Urologic Diseases

PHR: Chemoresistant prostate cancer is lethal with no cure. This Research Project is to develop bromocriptine, an approved non-oncology drug, as a safe, effective, and affordable precision therapy for the subtypes of chemoresistant prostate cancer. Our drug repurposing approach will allow a prompt translation from bench research into bedside care of cancer patients, therefore having significant public health impacts.

PI_NAMEs: WU, DAQING  (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;African American;androgen independent prostate cancer;Animals;anti-cancer research;Benign;Biological Markers;Biology;Bromocriptine;cancer care;cancer health disparity;Cancer Patient;cancer subtypes;cancer therapy;Caring;Caucasians;Cell Cycle Arrest;Cell Death;Cell Line;Chemoresistance;chemotherapy;Clinical;Clinical Pharmacology;Combined Modality Therapy;Complex;cost;Death Rate;Development;Disease;Disease Progression;docetaxel;Dopamine D2 Receptor;dosage;Dose;DRD2 gene;drug discovery;drug repurposing;European;Exhibits;Genetic;Growth;Heterogeneity;Human;improved;in vivo;inhibitor;innovation;Knowledge;Malignant neoplasm of prostate;Molecular;Molecular Target;mortality;mouse model;NCI Center for Cancer Research;Non-Insulin-Dependent Diabetes Mellitus;novel;Oral Administration;Outcome;patient derived xenograft model;Patients;Pattern;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;Phenotype;Positioning Attribute;potential biomarker;pre-clinical;Pre-Clinical Model;Precision therapeutics;preclinical efficacy;prostate cancer cell;Prostate Cancer therapy;Proteome;Public Health;Qualifying;Research;research and development;research clinical testing;Research Project Grants;Resistance;Route;Safety;Schedule;screening;Signal Transduction;skeletal;Solid;standard of care;targeted treatment;therapeutic development;therapeutically effective;Tissues;Toxic effect;Translating;Translations;trial design;Universities;Validation;Xenograft procedure

PROJECT_TITLE: RESEARCH PROJECT 1: DAQING WU


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Prostate Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Urologic Diseases

PI_NAMEs: CHAUDHARY, JAIDEEP  (contact)

PROJECT_TERMS: Address;advanced prostate cancer;alpha helix;androgen independent prostate cancer;Androgen Receptor;androgen sensitive;anti-cancer research;Apoptotic;Attenuated;Biology;cancer biomarkers;cancer cell;cancer stem cell;cancer survival;Castration;CD44 gene;Cells;Chemotherapy and/or radiation;Clinical;combat;combinatorial;Combined Modality Therapy;Complex;constitutive expression;Development;Differentiation Inhibitor;DNA Methylation;DU145;effective therapy;Epigenetic Process;epigenetic silencing;Epithelial Cells;Exhibits;EZH2 gene;FK506 binding protein 5;Genetic Transcription;Goals;Growth;Helix-Turn-Helix Motifs;histone methylation;Individual;inducible gene expression;Intervention;Knockout Mice;Ligands;LNCaP;Malignant neoplasm of prostate;Malignant Neoplasms;Molecular;Molecular Chaperones;Morphogenesis;Mus;Natural regeneration;NKX3-1 gene;novel;Nude Mice;Oncogenes;Oncogenic;Pathway interactions;PC3 cell line;Pharmaceutical Preparations;Phenotype;prevent;Prevention;programs;Property;Prostate;prostate cancer cell line;prostate cancer progression;Proto-Oncogene Proteins c-akt;PTEN gene;receptor expression;regenerative;Regulation;Resistance;Role;Signal Transduction;small molecule;Specific qualifier value;stem cell biomarkers;stem cell population;stem cells;stemness;Steroid Receptors;tacrolimus binding protein 4;Therapeutic;therapeutically effective;TP53 gene;tumor;tumor initiation;tumor progression;Tumor Promoters;Tumor Promotion;Tumor Suppressor Proteins;Tumorigenicity;Universities;Up-Regulation

PROJECT_TITLE: Epigenetic Silencing of Inhibitor of Differentiation 4 (ID4) Promotes Stem Cell and Castration Resistant Phenotype in Prostate Cancer


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Urologic Diseases

PI_NAMEs: CINAR, BEKIR  (contact)

PROJECT_TERMS: advanced disease;Affect;African American;African American population;American;androgen independent prostate cancer;Androgens;anti-cancer research;Attenuated;Behavior;Binding;Biochemical;Biological;Biology;bone;burden of illness;cancer cell;Cancer Cell Growth;Cancer Etiology;cancer health disparity;cancer initiation;cancer type;Castrate sensitive prostate cancer;Castration;Cause of Death;Cell Differentiation process;cell growth;Cell Line;cell motility;Cell Proliferation;Cells;Cessation of life;Chromatin;Chromatin Remodeling Factor;Clinical;clinically significant;cohort;Communities;Data;Data Set;Development;Disease;Disease Surveillance;disparity reduction;effective therapy;enzalutamide;Etiology;Exposure to;EZH2 gene;Gene Amplification;Gene Expression;Genetic Engineering;Genetic Transcription;Goals;Growth;hormonal signals;improved;in vivo;inhibitor;insight;Invaded;Knock-out;Knowledge;Laboratories;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Mass Spectrum Analysis;member;men;Metastatic Prostate Cancer;migration;Modeling;Molecular;mortality;Neoplasm Metastasis;Nuclear;Oncogenic;Outcome;Pathway interactions;Patient Care;Patient Selection;Patients;Pattern;Phenotype;Play;Polycomb;PRC1 Protein;preservation;Prognosis;Progression-Free Survivals;prostate cancer cell;prostate cancer cell line;prostate cancer model;prostate cancer progression;Prostatic Neoplasms;protein complex;protein protein interaction;Proteins;Proteomics;Quality of life;Race;Relapse;Research;Resistance;Role;Science;sex;Signal Transduction;stemness;targeted treatment;Tertiary Protein Structure;Testing;therapeutic target;Tissues;transcription factor;Transcription Regulatory Protein;Tropism;tumorigenesis;United States;Universities

PROJECT_TITLE: Crosstalk between YAP1 and Polycomb Group Protein SCML2 in Prostate Cancer


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Social Determinants of Health;Urologic Diseases

PROJECT_TERMS: Achievement;Address;African American population;anti-cancer research;Applications Grants;Area;Award;Basic Science;Behavioral;behavioral and social science;Behavioral Sciences;Benchmarking;Biological;biological research;Cancer Biology;cancer health disparity;career;career development;Communities;Data;Development;Discipline;Education;effective intervention;Faculty;Foundations;Funding;Funding Agency;Goals;Grant;Health Disparities Research;health disparity;improved;interdisciplinary approach;interdisciplinary collaboration;Investigation;Malignant neoplasm of prostate;Measures;Medical Research;member;Mentors;Methods;mid-career faculty;Minority Groups;Monitor;National Institute on Minority Health and Health Disparities;NCI Center for Cancer Research;Outcome;outreach;Peer Review;Performance;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;Process;professor;programs;prospective;Prostate Cancer therapy;Psychology;Publications;recruit;Research;research and development;Research Personnel;Research Proposals;Resources;Schools;Scientific Advances and Accomplishments;Scientist;skills;social;social factors;social science research;Social Sciences;Source;success;symposium;Teacher Professional Development;technology development;tenure track;Testing;theories;therapeutic development;Underserved Population;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: INVESTIGATOR DEVELOPMENT CORE


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

PI_NAMEs: LIOU, GEOU-YARH  (contact)

PROJECT_TERMS: Address;Administrator;African American;African American population;African Caribbean;American;animal care;anti-cancer research;Basic Science;Bioinformatics;Biological Factors;Biomedical Research;Biometry;Cancer Etiology;cancer health disparity;cancer type;Caucasians;Cellular biology;Cessation of life;Chemoresistance;Clinical Research;clinically relevant;cloud storage;Collaborations;Core Facility;Data;Data Storage and Retrieval;Death Rate;Development;Disparity;Ensure;Environmental Risk Factor;Equipment;Funding;Future;Genetic;Genomics;Histology;Image;Incidence;Infrastructure;instrument;instrumentation;Laboratories;Laboratory Personnel;Malignant neoplasm of prostate;Malignant Neoplasms;member;men;Methodology;Mission;Molecular Biology;NCI Center for Cancer Research;Neoplasm Metastasis;operation;Pathogenesis;Patients;Pharmaceutical Preparations;Pilot Projects;Postdoctoral Fellow;pre-clinical;pre-clinical research;Proteomics;racial disparity;Reproducibility;Research;research and development;research facility;Research Infrastructure;Research Personnel;Research Project Grants;Research Project Summaries;Research Support;Resources;Risk Factors;Role;Scientist;senior faculty;Services;Signal Transduction;structural biology;success;Techniques;Therapeutic;therapeutic development;Tissue Banks;tissue resource;tool;Training;Translational Research;Universities;Update;Vision

PROJECT_TITLE: RESEARCH CAPACITY CORE


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Patient Safety;Radiation Oncology

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  The overarching goal of this proposal is to enable clinical use of linear-energy-transfer (LET) in spot scanning proton therapy (SSPT) for head and neck (H&N) cancer based on patient outcomes with adverse event (AE) sites contoured using following-up medical images (CT, PET, and MR etc.) to minimize the risks of AEs. We will develop dose-LET volume histogram (DLVH) based plan evaluation and treatment planning methods in SSPT for H&N cancer management using patient outcomes and following-up medical imaging analysis-derived dose-LET volume constraints (DLVCs) and develop the empirical AE models using domestic seed spot analysis based on medical imaging analysis. The success of this study will open new avenues in SSPT plan evaluation and treatment planning, leading to precision radiation therapy and improved clinical outcomes.

PI_NAMEs: LIU, WEI  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adverse event;adverse event risk;Affect;Benchmarking;Biological;Biological Process;Brain;cell killing;Characteristics;Clinic;Clinical;clinical application;Clinical Data;clinical practice;clinically relevant;Complication;Control Groups;Data;Data Analyses;Deposition;Dose;Evaluation;Exclusion;Feedback;follow-up;Goals;Head and Neck Cancer;Head and neck structure;Image;Image Analysis;improved;in vivo;Incidence;Linear Energy Transfer;Location;Logistic Regressions;Magnetic Resonance Imaging;Maps;Medical Imaging;Methods;Modeling;Necrosis;New York;Noise;Normal tissue morphology;novel;Organ;Osteoradionecrosis;Outcome;patient variability;Patient-Focused Outcomes;Patients;Performance;Photons;Physics;population based;Positron-Emission Tomography;Probability;prospective;proton therapy;Protons;Quality of life;Radiation therapy;Reporting;Risk;risk minimization;Scanning;Serious Adverse Event;Signal Transduction;Site;Spottings;standard of care;Statistical Models;Structure;success;Surface;System;Technology;Testing;tool;treatment planning;tumor;Uncertainty;Universities;Variant;Visualization

PROJECT_TITLE: Dose Linear Energy Transfer Volume Histogram and Dosimetric Seed Spot Analysis in Spot Scanning Proton Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-B (02)]


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: BERKELEY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Chromatin and its fundamental unit, the nucleosome, constitute a mechanical barrier that controls DNA accessibility and is, therefore, a major mechanism of control of gene expression. Here, we combine biophysical approaches including optical tweezers, single-molecule fluorescence, cryo-electron microscopy/tomography, and in vivo quantitative confocal imaging to investigate how epigenetic modifications, pioneer factors, chromatin remodelers, chromatin- associated proteins, and histone chaperones modulate the magnitude of the mechanical barrier of a single nucleosome and nucleosome arrays, and how they affect transcription by Pol II. The precise measurement of these mechanistic details will provide the physical framework to understand how gene expression is regulated by chromatin.

PI_NAMEs: BUSTAMANTE, CARLOS JOSE (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Adopted;Affect;Binding Proteins;Biological Assay;biophysical techniques;Cells;CHD1 gene;Chromatin;confocal imaging;Cryo-electron tomography;Cryoelectron Microscopy;DNA;Drosophila genus;Elongation Factor;Embryo;Environment;Epigenetic Process;Eukaryotic Cell;experimental study;flexibility;Fluorescence;FOXO1A gene;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Genomic DNA;Histone H1;Histones;In Vitro;in vivo;in vivo fluorescence imaging;Individual;Ionic Strengths;laser tweezer;Length;live cell imaging;Measurement;mechanical properties;Mechanics;Methods;Modality;Modification;Molecular;Molecular Chaperones;Monitor;Nucleic Acids;Nucleosomes;optic tweezer;particle;Physical Chemistry;Play;Polymerase;Positioning Attribute;Post-Translational Protein Processing;protein crosslink;Proteins;reconstruction;Regulation;Repression;Resolution;RNA Polymerase II;Role;single molecule;Solvents;Spectrum Analysis;Structure;tomography;Transcription Elongation;Variant

PROJECT_TITLE: Physical Chemistry of Nucleic Acids

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Data Science;Digestive Diseases;Dissemination and Implementation Research;Machine Learning and Artificial Intelligence

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: NARRATIVE Dealing with cancer places great stress not only on the patient but also on that patient's spouse or partner, and couples find that communicating about cancer and how it is affecting their lives and relationship can become challenging even in the best of relationships. This study looks at how couples dealing with cancer communicate with each other across settings and time (within a single conversation and over the course of days and months), and whether patterns of communication can be identified that are associated with better or worse long-term emotional and relationship adjustment and well-being. This information will be used to develop screening tools to identify couples who may need more support and to explore how these tools can be used in clinical settings.

PI_NAMEs: LANGER, SHELBY  (contact);PORTER, LAURA S

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Address;Adoption;Affect;Affective;Area;Arousal;Behavior;Behavioral;brief screening;Cancer Patient;caregiving;Characteristics;Clinic;Clinical;clinical practice;Code;Cognitive;Collaborations;Colon Carcinoma;Colorectal Cancer;Communication;communication behavior;Consolidated Framework for Implementation Research;coping;Couples;Data;data integration;Data Science;Data Set;Development;Dimensions;Disclosure;Disease;Distress;Ecological momentary assessment;efficacious intervention;Emotional;Enrollment;Expressed Emotion;follow-up;Frequencies;Goals;implementation barriers;improved;Individual;International;Intervention;Interview;intimate behavior;large datasets;Machine Learning;machine learning method;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Methods;Modeling;Moods;multimodal data;novel;Oncology;Outcome;Participant;Partner Communications;Patient Self-Report;Patients;Pattern;Personal Satisfaction;Persons;Phase;Process;prospective;Provider;Psychological adjustment;psychological distress;Rectal Cancer;Reporting;Research;Risk;Sampling;satisfaction;Science;Screening procedure;social;Spouses;Statistical Methods;Stress;Testing;theories;therapy development;Time;tool;Video Recording

PROJECT_TITLE: Couple Communication in Cancer: A Multi-Method Examination - Renewal - 1

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Kidney Disease;Nutrition

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Mitochondrial dysfunction leading to metabolic dysregulation is a key component in the development of chronic kidney disease, a growing global health problem. The proposed studies will use a model to study kidney cell type-specific mitochondria to define the role of local ketone metabolism within the kidney. As suppression of a key ketogenic gene is associated with kidney disease, these studies will not only advance our understanding of kidney cell type-specific metabolism, but also identify potential therapeutic interventions to enhance kidney ketogenesis and prevent kidney disease.

PI_NAMEs: HUEN, SARAH  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;absorption;Acetyl Coenzyme A;Acute;Adult;Biochemical Pathway;Biological Assay;Breeding;Cell Separation;cell type;Cells;Chronic Kidney Failure;Coenzyme A-Transferases;combat;conditional knockout;Consumption;Data;data integration;Defect;Depressed mood;Development;Disease;Distal;Distal convoluted renal tubule structure;End stage renal failure;Enterobacteria phage P1 Cre recombinase;Enzymes;Exclusion;Exhibits;Fasting;fatty acid oxidation;Fatty Acids;Fibrosis;Functional disorder;Generations;Genes;Genetic Models;Genus Hippocampus;global health;Health;Homeostasis;Human;in vivo;Individual;Infusion procedures;Injury;Injury to Kidney;innovation;Investigation;Ischemia;ketogenesis;ketogentic;Ketones;Kidney;kidney biopsy;kidney cell;kidney cortex;Kidney Diseases;kidney metabolism;Knock-out;Knockout Mice;Label;Liver;Measures;Metabolic;Metabolism;metabolomics;Methods;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;multiple omics;Mus;nephrogenesis;novel;novel therapeutics;Nuclear RNA;Organ;overexpression;oxidation;Pathway interactions;Pattern;Perfusion;Peripheral;Phase;Predisposition;preference;Prevalence;prevent;Property;Proteomics;Proximal Kidney Tubules;renal ischemia;Reperfusion Injury;Research;Respiration;respiratory;response;Role;Source;Stress;Testing;Therapeutic Intervention;transcriptome sequencing;Tubular formation;United States;Work

PROJECT_TITLE: Defining intra-renal ketone metabolism in kidney health and disease

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Depression;Epilepsy;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Simultaneous brain-behavior quantification for mental states can provide novel neural-physiological markers to enable personalized therapies for diverse mental disorders but remains immensely difficult. Our interdisciplinary team will develop novel hardware and software tools that address several challenges on the physiology, behavior, machine learning, and ethics fronts to enable multimodal neural-physiological-behavioral sensing and machine learning for mental states. Our multimodal, convergent, and integrated tools will likely enable unique brain-behavior insights into human emotion functioning applicable to broad domains of mental health.

PI_NAMEs: SHANECHI, MARYAM  (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Accelerometer;Address;Affect;Anxiety;aptamer;Architecture;Arousal and Regulatory Systems;autism spectrum disorder;Behavior;Behavior monitoring;Behavioral;Biological Markers;Biomechanics;Brain;brain behavior;Chemicals;computer scientist;Computer software;Data;Data Collection;Data Reporting;deep learning;design;Diagnostic;Disease;Dissociation;Electrodes;Electroencephalography;emotional functioning;Emotions;Engineering;Enzyme-Linked Immunosorbent Assay;Epilepsy;Ethical Issues;Ethics;Evaluation;Facial Expression;Fright;Galvanic Skin Response;Generations;Goals;heart rate variability;high dimensionality;Human;Hydrocortisone;Implant;Individual;insight;Internet;Joints;Language;Learning;Machine Learning;Measurement;Measures;Mental Depression;Mental disorders;Mental Health;mental state;Methods;Modality;Modeling;Monitor;Moods;motion sensor;multimodal data;multimodal fusion;multimodal modeling;multimodality;National Institute of Mental Health;Natural Language Processing;Negative Valence;neural;neuromechanism;Neurosurgeon;Noise;novel;Operative Surgical Procedures;Participant;Patient Self-Report;Patients;personalized medicine;Physiologic Monitoring;Physiological;Physiology;Printing;Privacy;Psyche structure;Psychiatrist;recurrent neural network;Research Domain Criteria;response;Scientist;sensor;Site;Skin;social;social anxiety;Social Interaction;Social Processes;Software Tools;statistics;Stress;System;temporal measurement;Testing;Time;tool;Transistors;Trust;virtual human;wearable device

PROJECT_TITLE: Novel multimodal neural, physiological, and behavioral sensing and machine learning for mental states

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-E (01)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Disease;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Methionine adenosyltransferase (MAT) is an essential enzyme as it is responsible for the formation of S- adenosylmethionine, a key molecule that is required for normal cell function. Normal liver expresses mainly MAT1A and patients with alcohol-associated liver disease (ALD) have reduced expression of MAT1A. We have found MAT1A protein is selectively depleted in the nucleus and mitochondria in ALD, and this can lead to abnormal gene expression and mitochondrial injury. The goals of this project are to understand the underlying mechanisms for depletion of MAT1A protein in these organelles, their consequences and whether targeting them can protect from the development of ALD.

PI_NAMEs: LU, SHELLY CHI-LOO (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Address;Alcoholic Liver Diseases;Alcohols;Amides;Anabolism;Antioxidants;Area;Binding;Biological;casein kinase II;Catalytic Domain;Cell Nucleus;Cell Physiology;ChIP-seq;cis-trans-Isomerases;cofactor;CRISPR/Cas technology;CYP2E1 gene;Cytosol;Data;Development;dimer;DNA methylation profiling;efficacy evaluation;Enzymes;Epigenetic Process;epigenome;Event;extracellular vesicles;follow-up;FOXM1 gene;Funding;Future;Gene Abnormality;Gene Expression;Genes;Genetic Transcription;genome-wide;Glutathione;Goals;Hepatocyte;Histones;Human;Impairment;In Vitro;in vivo;Inflammation;Injury;Isoenzymes;Isomerism;Knockout Mice;Link;Liver;Liver diseases;liver injury;LoxP-flanked allele;Mammals;Mediating;methionine adenosyltransferase;Methylation;Mitochondria;Mitochondrial Matrix;Modeling;Molecular Conformation;Mus;National Institute on Alcohol Abuse and Alcoholism;Nature;new therapeutic target;NIMA;Normal Cell;novel;Nuclear;Nuclear Export;Nuclear Import;Nuclear Localization Signal;Oncoproteins;Organelles;Patients;Peptide Signal Sequences;Peptidylprolyl Isomerase;Phosphorylation;Population;Post-Translational Protein Processing;prevent;Process;Proline;Proteins;Protocols documentation;Regulation;Reporting;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Serine;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;Sumoylation Pathway;Testing;transcriptome sequencing;Up-Regulation;Work

PROJECT_TITLE: Methionine Adenosyltransferase α1 and Its Interactome in Alcohol-Associated Liver Disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biotechnology;Genetics;Lung;Rare Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE In this proposal, an RNA regulation mechanism through NUDT21 is demonstrated to play a critical role in regulating macrophage function and inflammation during Acute Respiratory Distress Syndrome (ARDS), a prevalent and life-threatening lung injury. We designed a series of cellular and animal studies to prove whether modulating the NUDT21 pathway in macrophages could attenuate ARDS. These studies can ultimately lead to the discovery of new targets for the treatment of ARDS patients.

PI_NAMEs: MILLS, TINGTING WENG (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: 3' Untranslated Regions;Acute;Acute Respiratory Distress Syndrome;Algorithms;alveolar epithelium;Animals;Attenuated;Bacterial Infections;Binding;Bioinformatics;Biological Assay;Bone Marrow;Bronchoalveolar Lavage;Bypass;Cells;comparison control;cytokine;Cytometry;Data;design;Development;Disease;Distal;Down-Regulation;Edema;Epithelial Cells;Event;gain of function;Gene Expression;Genes;Genetic study;Goals;Human;Hypoxemia;Hypoxia;Hypoxia Inducible Factor;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory lung disease;inflammatory marker;inhibitor;innovation;Internal Ribosome Entry Site;Investigation;Knock-out;Knockout Mice;Length;Life;Lipopolysaccharides;Lung;lung injury;Macrophage;Mediating;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myelogenous;novel;novel strategies;novel therapeutic intervention;nudix hydrolase;overexpression;Pathogenesis;Pathway interactions;Patients;Play;Poly(A) Tail;Polyadenylation;posttranscriptional;prevent;Production;protein expression;Proteins;Pseudomonas aeruginosa;Pulmonary Inflammation;Regulation;Repression;Resources;RNA;RNA-Binding Proteins;Role;Sampling;screening;Series;single-cell RNA sequencing;Site;Technology;Testing;Therapeutic;therapeutic target;Tissues;Transcript;transcription factor;transcriptome sequencing;Translating

PROJECT_TITLE: Macrophage NUDT21-mediated alternative polyadenylation in lung injury

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: AMHERST

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Narrative Our research demonstrated that a mobile produce market can have a significant positive impact on diets of residents in lower-income communities. We want to test this program more widely to determine if the effect can be replicated and develop a best-practices toolkit to help others sustainably implement the program.

PI_NAMEs: LEONE, LUCIA A (contact)

PROGRAM_OFFICER_NAME: AGURS-COLLINS, TANYA

PROJECT_TERMS: Behavior Therapy;Body mass index;Businesses;Carotenoids;Chronic;cluster randomized design;Cluster randomized trial;Communities;community college;community engaged approach;community engagement;community organizations;Community Outreach;Computer software;Consumption;Control Groups;cooking;cost;Country;Data;Dermal;design;Diet;dietary;Dose;Eating;Education;Effectiveness;effectiveness measure;effectiveness testing;effectiveness/implementation hybrid;environmental intervention;Evaluation;Face;farmers markets;Fatty acid glycerol esters;Feedback;Fingers;flexibility;follow-up;Food;Food Access;food environment;Food Preferences;fruits and vegetables;Funding;Future;Health;health disparity;Health Food;Healthy Eating;Heart Diseases;Height;Hour;Housing;hybrid type 1 design;implementation framework;implementation process;Improve Access;improved;Income;Individual;informant;Intake;Intervention;intervention participants;Interview;Knowledge;Low income;Low Income Population;Malignant Neoplasms;Marketing;Measurement;Measures;member;Minority;Minority Groups;Modeling;Neighborhood Health Center;Neighborhoods;Nonprofit Organizations;North Carolina;nutrition education;Obesity;Outcome;Participant;Patient Self-Report;Periodicals;Persons;Population;Preparation;Price;Process;process evaluation;Process Measure;Program Effectiveness;programs;Qualifying;Randomized;Randomized, Controlled Trials;recruit;Reporting;Request for Proposals;Research;research study;Running;Sales;saturated fat;Scanning;Selection Criteria;Self Efficacy;Site;skills;social cognitive theory;Socioeconomic Status;Sodium;success;sugar;Surveys;Techniques;Telephone;Testing;theories;Time;underserved community;Unhealthy Diet;Update;Vulnerable Populations;Weight

PROJECT_TITLE: Effectiveness and Implementation of a Research Tested Mobile Produce Market Designed to Improve Diet in Underserved Communities


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Genetics;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative This project will employ state-of-the-art molecular, biochemical, and genetic techniques in mice to identify the cell types and mechanisms that regulate and functionally recruit the IGF-2/IGF-2R system in the hippocampus to form long-term memory. It will test the hypotheses that IGF-2 released by specific cell types, such as pericytes, activates IGF-2R expressed by target cells, such as neurons, to regulate, via vesicle trafficking, de novo translation induced by learning and its coupling to autophagy, a fundamental molecular node that controls plasticity changes essential for memory formation. Targeting this novel mechanism should provide important insights for treating disorders associated to memory impairment.

PI_NAMEs: ALBERINI, CRISTINA M (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Affinity;Alzheimer's Disease;Angelman Syndrome;Astrocytes;autism spectrum disorder;Autophagocytosis;Award;Basal Cell;base;Behavioral;Binding;Biochemical;Biochemistry;Biological;Biology;Brain;Brain region;CCAAT-Enhancer-Binding Proteins;cell type;Cells;Coupling;Cyclic AMP-Responsive DNA-Binding Protein;Data;Defect;Dependovirus;Development;Disease;Dorsal;effective therapy;Endosomes;Endothelial Cells;enhancer binding protein;Enterobacteria phage P1 Cre recombinase;Episodic memory;excitatory neuron;Fibroblasts;Frontotemporal Dementia;Gene Expression;Genes;Genetic Techniques;Goals;Hippocampus;Huntington Disease;IGF Type 2 Receptor;IGF2R gene;Immunohistochemistry;Impaired cognition;In Situ Hybridization;inhibitory neuron;insight;Insulin-Like Growth Factor II;Investigation;knock-down;Knock-out;Learning;Ligands;long term memory;LoxP-flanked allele;Lysosomes;mannose 6 phosphate;Mediating;Memory;memory consolidation;Memory impairment;Memory Loss;memory retention;memory retrieval;Methods;Microglia;Molecular;mouse genetics;mouse model;mRNA Translation;Mus;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuronal Plasticity;Neurons;novel;Oligodendroglia;Organelles;Outcome;Parkinson Disease;Pathologic;Pathway interactions;Pericytes;prevent;Process;promoter;Protein Biosynthesis;protein degradation;protein metabolism;Proteins;Proteomics;Publications;Rattus;receptor;Receptor Activation;Recombinants;recruit;Research;resilience;response;ribosome profiling;Role;Site;spatial memory;System;Techniques;Testing;Time;tool;trafficking;Training;transcription factor;transcriptome sequencing;Translating;Translations;Transmission Electron Microscopy;Vascular Dementia;Vesicle;WAVE protein;Work

PROJECT_TITLE: Gene Expression in Long-Term Memory

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Immunotherapy;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PIs: Bradshaw, Elizabeth M., Ph.D. and Wassim Elyaman, Ph.D. Title: Microglia antigen presentation in the CNS of Alzheimer's disease Project Narrative Relevance to public health. This project is of direct relevance to Alzheimer's disease, as we are studying isolated immune populations from the CNS of individuals with Alzheimer's disease. We will be examining the phenotype, antigens being presented and antigen reactivity of individual single-immune cells. We will be examining the interaction of the pathogen hypothesis and the CNS immune cells in the human system.

PI_NAMEs: BRADSHAW, ELIZABETH M;ELYAMAN, WASSIM  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Age;age related neurodegeneration;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease risk;antigen binding;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Area;Autoimmune Diseases;Autopsy;B-Lymphocytes;Bar Codes;Binding;Blood;Blood Vessels;Brain;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Separation;Cells;Central Nervous System;Clone Cells;Complex;cytokine;cytotoxic;Dementia;Dendritic Cells;DNA;Doctor of Philosophy;Effector Cell;Etiology;Event;Extracellular Protein;Genes;genetic association;Genetic Predisposition to Disease;Genetic study;genome wide association study;Goals;Hippocampus;Histocompatibility Antigens Class II;HLA Antigens;Human;Immune;Immune response;Immune system;Impaired cognition;in vivo;Individual;Infectious Agent;Infiltration;Innate Immune System;insight;Label;Late Onset Alzheimer Disease;Libraries;Link;Macrophage;Major Histocompatibility Complex;Microglia;Morphology;Names;Natural Killer Cells;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;neuropathology;novel;Older Population;Parkinson Disease;pathogen;pathogenic bacteria;pathogenic fungus;pathogenic virus;Pathogenicity;Pathology;Peptides;Peripheral;Phase;Phenotype;Population;Predisposition;Prefrontal Cortex;Process;Proteins;Public Health;Regulatory T-Lymphocyte;Reporting;Resolution;response;Risk Factors;Role;Senile Plaques;Specificity;Stains;Susceptibility Gene;System;T cell infiltration;T cell receptor repertoire sequencing;T-Cell Activation;T-Lymphocyte;Techniques;Technology;Validation;Viral