NIH_SPENDING_CATS: Bioengineering;Biotechnology;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SACRAMENTO

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA STATE UNIVERSITY SACRAMENTO

PHR: Project Narrative The supplement will provide a high-speed centrifuge with rotors to support a project aimed at the discovery and characterization of novel compounds that hold promise as novel antimalarial agents. The requested instrument is essential for the planned research and will replace an older model that broke down recently.

PI_NAMEs: PAULA, STEFAN FRANZ (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Age;Anti-malarials;Artemisinins;ATP phosphohydrolase;Binding Sites;Biological Assay;Biomedical Research;Ca(2+)-Transporting ATPase;Calcium;Chemicals;Chemistry;chemotherapy;Chloroquine;combat;Communicable Diseases;Communities;Complex;Computational Technique;Computing Methodologies;cost;Culicidae;Dangerousness;Development;Disease;Docking;drug candidate;drug development;Drug resistance;Drug Targeting;Education;Educational process of instructing;Effectiveness;Elements;Environment;Enzymatic Biochemistry;Enzyme Interaction;Enzymes;experimental study;fighting;Foundations;Generations;global health;Goals;Grant;Group Meetings;Homology Modeling;Hour;Hydroquinones;Infection;inhibitor;innovation;Institution;instrument;interest;Ion Transport;Knowledge;Libraries;Life;Ligands;Malaria;Measures;Mediating;Membrane;Methods;Modeling;Modification;Molecular;molecular dynamics;molecular modeling;multidisciplinary;Naphthoquinones;Nature;new therapeutic target;novel;novel therapeutics;Organic Synthesis;Parasites;Pharmaceutical Preparations;Pharmacology;Physiological;Plasmodium;Plasmodium falciparum;Preventive;programs;Property;Proteins;Protocols documentation;prototype;Publications;Quantitative Structure-Activity Relationship;Recombinants;repaired;Reporting;Research;Research Personnel;resistant strain;Saccharomyces cerevisiae;Sampling;scaffold;Site-Directed Mutagenesis;skills;small molecule;small molecule inhibitor;Speed;Structural Models;Structure;student training;Students;symposium;Therapeutic Agents;Time;tool;Training;transmission process;undergraduate research;undergraduate student;underrepresented minority student;vaccine development;Validation;Vendor;virtual

PROJECT_TITLE: Development of phenolic small molecule inhibitors of PfATP6, a Plasmodium calcium ATPase


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NOVATO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

ORG_STATE: CA

PHR: OVERALL PROJECT NARRATIVE  Age is the most important risk factor for developing Alzheimer’s disease and related dementias, but the mechanisms and development of successful treatments remain elusive. We propose to determine how age- related changes in both neurons and non-neuronal brain cells can drive these pathologies, with the long term goal of using these insights into effective interventions.

PI_NAMEs: ELLERBY, LISA M (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: 3-Dimensional;Affect;Age;age related;age related changes;age related neurodegeneration;Age-associated memory impairment;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Applications Grants;Astrocytes;Automobile Driving;Bioinformatics;Brain;brain cell;Cell Aging;Cell Communication;Cell Culture Techniques;Cell Death;cell type;Cells;Clinical;Collaborations;cost;Data;Dementia;Development;Disease;Disease Progression;Economics;effective intervention;effective therapy;Emotional;Endothelial Cells;Etiology;Family;Goals;Head;Human;induced pluripotent stem cell;Inflammation;insight;interest;Intervention;Knowledge;Macrophage;member;Metabolic;Metabolism;metabolome;Modeling;Molecular;mouse model;Mus;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurons;novel;novel strategies;Oligodendroglia;Organoids;Pathology;Patients;Pharmaceutical Preparations;Phenotype;Population;Productivity;Program Research Project Grants;programs;Proteome;Proteomics;Publishing;Recording of previous events;Research;Research Personnel;Research Project Grants;response;Risk;Risk Factors;Role;senescence;senescent cell;senolytics;social;Testing;Time;transcriptomics;Translating

PROJECT_TITLE: Cellular senescence and cell fate/interactions as drivers of Alzheimer's and age-related dementias


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Physical Injury - Accidents and Adverse Effects;Sarcopenia

ORG_CITY: Houston

ORG_NAME: RIDGELINE THERAPEUTICS, LLC

ORG_STATE: TX

PHR: PROJECT NARRATIVE RT-002, a novel mechanism-of-action small molecule therapeutic developed by Ridgeline Therapeutics, effectively rejuvenates aged skeletal muscle satellite cells and stimulates recovery following musculoskeletal injury. This supplemental project will complete the final critical GLP toxicity/toxicokinetic minipig study needed to submit an investigational new drug (IND) application to begin clinical trials of RT-002 to accelerate functional recovery from hip injuries in elderly patients.

PI_NAMEs: NEELAKANTAN, HARSHINI  (contact)

PROGRAM_OFFICER_NAME: FOX, JENNIFER THERESA

PROJECT_TERMS: Acceleration;Acute;Administrative Supplement;Adult;Adverse effects;Age Years;aged;Aldehyde oxidase;Award;Biological Availability;Blood;Body Weight;Canis familiaris;Cardiac;Cardiotoxicity;Cells;Clinical;clinical candidate;Clinical Pathology;Clinical Trials;cohort;cost;Desire for food;Dose;Dose Limiting;drug candidate;Drug Kinetics;efficacy validation;Elderly;Electrocardiogram;Enzymes;Erythrocytes;Feces;Female;food consumption;Funding;Hepatocyte;Hip Fractures;Hip Injuries;Histology;Human;human old age (65+);In Vitro;in vivo;Investigational Drugs;Investigational New Drug Application;Kilogram;male;manufacture;Measures;meetings;Metabolic;metabolic abnormality assessment;Metabolic Biotransformation;Microscopic;Miniature Swine;Monkeys;Mus;Muscle;muscle aging;Muscle function;muscle progenitor cell;muscle strength;musculoskeletal injury;NAT2 gene;National Institute on Aging;neutrophil;novel;novel therapeutics;old mice;older patient;Operative Surgical Procedures;Ophthalmology;Oral;Organ Weight;Outcome;Pharmaceutical Preparations;Pharmacology Study;Phase;Pre-Clinical Model;preclinical development;preclinical safety;Process;process optimization;programs;Quality of life;Rattus;Recovery;Recovery of Function;Regimen;Rejuvenation;repaired;Rodent;Safety;scale up;Serum;sex;Skeletal Muscle;Skeletal Muscle Satellite Cells;small molecule therapeutics;stem cells;Therapeutic;therapeutic development;Time;Tissues;Toxic effect;Toxicokinetics;Toxicology;Troponin;U-Series Cooperative Agreements;Validation;validation studies

PROJECT_TITLE: Preclinical Development of a Novel Therapeutic to Rejuvenate Aging Muscle Stem Cells and Enhance Muscle Strength and Function Post Hip Fracture


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: YORK

ORG_NAME: ASSOCIATION OF FOOD AND DRUG OFFICIALS

ORG_STATE: PA

PHR: AFDO 2024 Alliance to Support the Activities of the Integrated Food Safety System (IFSS), Including the Grade A Milk Safety and National Shellfish Sanitation Programs  Application: Project Narrative The Association of Food and Drug Officials’ (AFDO) efforts under this cooperative agreement are intended to facilitate long-term improvements to the national food safety system by strengthening federal – state collaborations and improving state’s regulatory surveillance and protection programs for manufactured foods, Grade A milk, and shellfish sanitation programs. AFDO will support and contribute to the Manufactured Food Regulatory Program Alliance (MFRPA) as they work with states to develop best practices, develop and support training initiatives, and assist state programs in achieving programmatic improvement and conformance with the Manufactured Food Regulatory Program Standards (MFRPS). Through effective interagency collaboration, workforce development strategies, development of critical communication and data sharing strategies, and funding for state Grade A Milk and Shellfish program training and equipment, this project will help achieve a nationally Integrated Food Safety System (IFSS) and assist the U.S. Food and Drug Administration (FDA) in achieving their mandates under the Food Safety Modernization Act (FSMA).

PI_NAMEs: KENNELLY, PATRICK  (contact)

PROGRAM_OFFICER_NAME: LAC, ANH

PROJECT_TITLE: Continuing to Support and Enhance an Integrated Food Safety System Through Implementation of Program Standards, Data Sharing, Collaboration, and State Training and Equipment Grants.

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 ORA-T (04)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE This proposal seeks to develop a new class of b-strand/sheet mimics capable of disrupting the aggregation of amyloid proteins. These compounds will be used to selectively target the fibrilization and transmission of toxic tau filaments from cell to cell. The research plan incorporates chemical synthesis, structural characterization, and biological evaluation of novel peptide and protein mimics to probe neurodegenerative protein assemblies.

PI_NAMEs: DEL VALLE, JUAN R (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Adopted;alpha helix;Alzheimer's Disease;Alzheimer's disease patient;Amination;Amyloid;amyloid formation;Amyloid Proteins;Amyloidosis;aqueous;Area;beta pleated sheet;Binding;Biological;Biological Assay;Brain;Brain Diseases;Cells;Characteristics;chemical synthesis;Chemicals;corticobasal degeneration;Cryoelectron Microscopy;Cues;Data;design;Development;Diagnostic;Disease;DNA;Enzyme-Linked Immunosorbent Assay;Evaluation;Event;Excision;Exhibits;Face;Filament;flexibility;Fluorescence;Frontotemporal Dementia;Growth;Hydrogen Bonding;In Vitro;Inherited;inhibitor;interest;Lead;Libraries;Ligands;mimicry;Modeling;Modification;Molecular Conformation;Molecular Probes;Morphology;mutation screening;Nerve Degeneration;Neurodegenerative Disorders;neurotoxic;novel;Pathogenicity;Pathologic;Patients;Peptide Hydrolases;Peptides;peptidomimetics;Phenotype;Phosphoric Monoester Hydrolases;Phosphotransferases;Pick Disease of the Brain;Play;Polymorph;protein aminoacid sequence;Protein Conformation;protein folding;Protein Isoforms;protein protein interaction;protein structure;Proteins;Recombinants;Reporter;Research;Resistance;Resolution;Role;Scanning;Secondary Protein Structure;Series;Solid;solid state;Structure;Surface;System;tau aggregation;tau mutation;tau Proteins;Tertiary Protein Structure;Testing;Therapeutic;Translating;transmission process;Vertebral column

PROJECT_TITLE: Chemical approaches to selectively target beta-rich amyloidosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-M]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: TUCSON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative/ Public Health Relevance Inflammatory bowel diseases (IBD) are complex, multifactorial disorders characterized by impaired host- microbiome interactions that lead to chronic and relapsing intestinal inflammation with an incompletely understood etiology. In the parent application, we demonstrated that poly-ADP-ribosylation (PARylation), a post-translational protein modification known to profoundly affect cellular functions in other systems, plays an active role in gut epithelial cell biology, host-microbiome interactions, and mucosal inflammatory responses. This administrative supplement is geared towards providing additional support for a minority graduate student (Catherine Ellis), an exceptional PhD candidate in the Kiela lab, who identified a novel pathway responsible for promoting pathological and excessive PARylation in the inflamed gut mucosa, thus contributing to the severity and progression of inflammation.

PI_NAMEs: GHISHAN, FAYEZ KHALAF;KIELA, PAWEL R (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Address;Adenosine Diphosphate Ribose;Administrative Supplement;ADP ribosylation;Affect;Amino Acids;anti aging;bacterial community;Biology;candidate identification;Cell Compartmentation;Cell Physiology;Cellular biology;Chronic;Coenzyme A;cofactor;Colitis;Colon;commensal bacteria;comparative;Complex;Data;design;Disease;DNA Repair Enzymes;Doctor of Philosophy;efficacy evaluation;Energy Metabolism;Epithelial Cells;Epithelium;Etiology;FDA approved;fecal transplantation;Functional disorder;gastrointestinal;gastrointestinal epithelium;Genetic Transcription;Germ-Free;gut inflammation;gut microbiota;Gut Mucosa;Homeostasis;host microbiome;Human;Hyperactivity;Immune response;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Bowel Diseases;inflammatory marker;Inflammatory Response;inhibitor;Injury;Knock-out;Lactosylceramides;large bowel Crohn's disease;lipidomics;Lipids;Maintenance;Marketing;Mediating;Metabolic;metabolomics;Microbe;microbial community;microbial composition;microbiota;Mind;Minority Graduate Student;Modeling;Mucositis;Mucous Membrane;murine colitis;Mus;nicotinamide-beta-riboside;novel;oral supplementation;Outcome;parent grant;parent project;Parents;Pathogenesis;Pathologic;Pathway interactions;Patients;pharmacologic;Play;Poly(ADP-ribose) Polymerases;Polymerase;Post-Translational Protein Processing;Predisposition;Process;protein function;Proteins;public health relevance;Recovery;Regulatory T-Lymphocyte;Relapse;Risk;Role;Sampling;screening;Severities;Sirtuins;Sphingolipids;stool sample;Stress;Supplementation;System;Testing;Work

PROJECT_TITLE: Diversity Supplement to PARP1 and PARylation as novel effectors of gut inflammation

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

PHR: Project Narrative – Parent Grant P30 CA010815 Members of the Wistar Cancer Center elucidate the mechanistic underpinning of malignancy, pursue innovative disease models, and identify novel tumor vulnerabilities suitable for therapeutic intervention. Driven by collaboration and partnership, the Wistar Cancer Center delivers on innovative basic and translational cancer research, brings cutting-edge science to the community, trains the next generation of research leaders, and strives to advance its discoveries to the clinic for the benefit of cancer patients and their families.

PI_NAMEs: ALTIERI, DARIO C (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Adoptive Transfer;anti-PD-1;Antigen-Presenting Cells;Antigens;Antitumor Response;Autologous;Autologous Tumor Cell;B-Lymphocytes;Basic Cancer Research;Biological Assay;Cancer Center;Cancer Center Support Grant;cancer immunotherapy;Cancer Patient;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Communication;Cell Line;cell type;Cells;Center Core Grants;checkpoint therapy;Clinic;Clinical Trials;Collaborations;Communities;Complex;CTLA4 gene;cytotoxicity;Dendritic Cells;disease model;dosage;Drug resistance;Environment;Epithelial Cells;Evaluation;exome sequencing;experience;Experimental Models;Family;Fibroblasts;Generations;Goals;Grant;Growth;Hematopoietic stem cells;Histocompatibility;Human;humanized mouse;Immune;Immune checkpoint inhibitor;Immune response;Immunologics;Immunooncology;Immunotherapy;improved;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;inhibitor;innovation;Investigation;keratinocyte;Laboratories;Lesion;Macrophage;Malignant Neoplasms;mast cell;Mature T-Lymphocyte;Mediating;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;member;Mesenchymal;Minor;Modeling;Modification;monocyte;mouse model;Mus;Natural Killer Cells;neoantigens;neoplastic cell;next generation;novel;novel strategies;novel therapeutic intervention;Organ;Organoids;parent grant;patient derived xenograft model;Patient Selection;Patients;Peptides;Peripheral Blood Mononuclear Cell;Phenotype;Preparation;programmed cell death ligand 1;programmed cell death protein 1;Protein Array;Protein Fragment;Proteins;Protocols documentation;reconstitution;Relapse;repository;Reproducibility;Research;Resistance;Resistance development;response;Role;Science;Sequential Treatment;Skin;Source;Specialized Program of Research Excellence;Specificity;stem;Structure;System;T cell receptor repertoire sequencing;T cell response;T-Cell Development;T-cell diversity;T-Cell Receptor;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic Intervention;therapy resistant;Thymic epithelial cell;Thymus Gland;Training;transcriptome sequencing;translational cancer research;translational potential;tumor;Tumor Antigens;tumor microenvironment;tumor specificity;Tumor-infiltrating immune cells

PROJECT_TITLE: Immunological approaches to overcoming therapy resistance in human tumors


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE Reactive astrocytes are common features of neurodegenerative diseases and normal aging, but their role is still poorly understood and can encompass both beneficial and harmful effects. Understanding the molecular mechanisms that lead to astrocyte activation and defining the heterogeneity of astrocyte activation will lead to novel astrocyte-targeted therapies. This training proposal aims to understand the causes and effects of astrocyte reactivity in the context of Alexander Disease (Aim 1) and aging and neurodegeneration (Aim 2).

PI_NAMEs: BATTAGLIA, RACHEL  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Affect;Age;age related neurodegeneration;Aging;aging process;aging related disease;Alexander Disease;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Antibodies;Astrocytes;autosomal dominant mutation;axon growth;Biological Assay;Biology;Brain;Calcium Signaling;career;casein kinase;casein kinase II;CASP6 gene;cell type;Cells;Central Nervous System;Central Nervous System Diseases;central nervous system injury;Coculture Techniques;CRISPR/Cas technology;Cytoskeleton;Data;Development;Disease;Disease Progression;Drosophila genus;efficacy evaluation;Environment;experience;experimental study;Extracellular Matrix;Fiber;fly;Functional disorder;Future;Gene Expression;Generations;Genes;Genetic;genetic approach;gerotherapeutic;Glial Fibrillary Acidic Protein;Glycoproteins;Glypican;Goals;Heparan Sulfate Proteoglycan;Heparitin Sulfate;Heterogeneity;Human;human induced pluripotent stem cells;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inflammation;Intermediate Filament Proteins;Knock-out;leukodystrophy;Link;Maintenance;Mass Spectrum Analysis;Measures;Mechanics;Mediating;Missense Mutation;Modeling;Modification;Molecular;Morphology;mouse model;Mus;mutant;Mutate;Mutation;Nerve Degeneration;nervous system development;Neurodegenerative Disorders;Neurodevelopmental Disorder;neurogenesis;Neuroglia;neuronal growth;Neurons;normal aging;novel;novel therapeutic intervention;Pathologic;Pathway interactions;Patients;pharmacologic;Phase;Phenotype;Phosphorylation;Phosphotransferases;Physiological;Play;Postdoctoral Fellow;prevent;programs;protein aggregation;Protein Secretion;Proteoglycan;Proteolysis;Proteomics;proteostasis;Research;Research Personnel;Research Project Grants;response to injury;Role;Secretory Component;Severity of illness;Signal Transduction;Site;small molecule inhibitor;synaptogenesis;System;targeted treatment;Techniques;Testing;Toxic effect;Training;Treatment Efficacy;Work

PROJECT_TITLE: Function of reactive astrocytes in aging and neurodegenerative disease


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: In this multicomponent application for an Administrative Supplement for U54 AI170752, the first component will accelerate membrane protein technologies for HIV-1 Env studies, aimed at structural dissection of the mechanisms of antibody interactions to the Membrane Proximal External Region (MPER), understanding HIV- 1 coreceptor tropism and elucidating the mechanism of a gp41 directed fusion inhibitor. The second component will add a Direct Detector Camera to our existing Tundra microscope to enable routine high resolution cryo-EM data acquisition for HIV-1 Env samples. The third component will acquire a Nanotemper Monolith X for robust equilibrium measurement of challenging biomolecular interactions with minimal sample consumption.

PI_NAMEs: ACHARYA, PRIYAMVADA  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Acceleration;Administrative Supplement;Affinity;Antibodies;Area;B-Cell Antigen Receptor;Binding;biological systems;Biology;career;Cells;Clinical Trials;Collaborations;Complex;Computer Analysis;Consumption;Country;Coupled;Cryo-electron tomography;Cryoelectron Microscopy;Data;data acquisition;Data Collection;detector;Disease Progression;Dissection;Drug Targeting;Ensure;env Gene Products;Enzyme-Linked Immunosorbent Assay;Epitopes;Equilibrium;Equipment;Event;expectation;experimental study;Funding;G-Protein-Coupled Receptors;global health;Goals;Hand;Highly Active Antiretroviral Therapy;HIV;HIV-1;immune activation;Infection;inhibitor;insight;Knowledge;Measurement;Measures;Mediating;Medicine;Membrane;Membrane Proteins;memory CD4 T lymphocyte;Methods;Microscope;mimetics;Molecular;Molecular Conformation;Morbidity - disease rate;mortality;neutralizing antibody;news;novel;novel vaccines;particle;Persons;Preventive vaccine;Production;Proteins;Publications;receptor;Reporting;Reproducibility;Research;Resolution;Rest;Role;Sampling;Scientist;Site;structural biology;Structure;System;Technology;Time;tool;Training;transmission process;trend;Tropism;Vaccination;Vaccines;Viral;viral rebound;Virus Latency;World Health Organization


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Neurosciences;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Cytomegalovirus viremia is associated with mortality in persons with advanced HIV disease. It is unknown if cytomegalovirus viremia is driving the risk, or is rather a sensitive marker of immune dysfunction in those at risk for poor clinical outcomes. The objective of this study is to determine the dynamics of CMV viremia over time in persons with advanced HIV disease and concomitant cryptococcal meningitis, to establish how CMV viremia impacts mortality in a time-dependent fashion, and to identify if an impaired host immune response is associated with active CMV viremia.

PI_NAMEs: SKIPPER, CALEB P (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Africa;AIDS-Related Opportunistic Infections;anti-fungal agents;Anti-Retroviral Agents;Antigens;Automobile Driving;Biological Assay;Biometry;career;CD4 Lymphocyte Count;CD4 Positive T Lymphocytes;Cell Count;cell mediated immune response;Cell surface;Cells;Central Nervous System;Central Nervous System Infections;Cessation of life;Clinical;Clinical Immunology;Clinical Trials;Clinical Trials Design;cohort;Collaborations;Communicable Diseases;Competence;Conduct Clinical Trials;Cryptococcal Meningitis;Cryptococcus;cytokine;Cytomegalovirus;Data;Data Analyses;design;Development;Diagnosis;Disease;DNA;Education;Enrollment;Ethics;Excess Mortality;Exclusion Criteria;experience;Exposure to;Flow Cytometry;Future;Goals;hazard;Helper-Inducer T-Lymphocyte;high risk;HIV;HIV/AIDS;Human;Immune;immune reconstitution;Immune response;Immune System Diseases;Immunity;Immunologic Markers;Immunology;immunoregulation;Impairment;improved;improved outcome;Inflammatory;interest;Interferon alpha;Interferon Type II;Interferons;International;Intervention;Intervention Trial;Knowledge;magnetic beads;Measurement;Measures;Medicine;Meningitis;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Minnesota;Modeling;mortality;mortality risk;Mycoses;Neurocognitive;Opportunistic Infections;Organ;Organ Transplantation;Outcome;Participant;pathogen;Patients;Peripheral Blood Mononuclear Cell;Persons;Pharmacotherapy;Phenotype;Plasma;Population;population stratification;prevent;Prevention;professor;prospective;Publishing;randomized trial;randomized, clinical trials;Recommendation;Relapse;Research;Research Personnel;Resource-limited setting;response;Risk;Risk Factors;risk mitigation;risk prediction;risk stratification;routine care;screening;Serum;Severities;skills;Solid;sound;study population;subcutaneous;Syndrome;T cell response;T-Cell Activation;Testing;therapy design;Time;Training;translational immunology;Translational Research;Universities;Viremia

PROJECT_TITLE: Impact of longitudinal CMV viremia on opportunistic neuroinfections in advanced HIV disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Regenerative Medicine

ORG_CITY: MILWAUKEE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Not Applicable

PI_NAMEs: VELDMAN, MATTHEW B (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Cholesterol;mevalonate;optic nerve regeneration;Pathway interactions;Regulation

PROJECT_TITLE: Regulation of successful optic nerve regeneration by the mevalonate/cholesterol pathway


ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The 2025 meeting of the SBSRN will be co-hosted by the Penn and UNC CFARs and will partner with the Inter-CFAR Substance Use Research Committee (I-SURC) and the National CFAR CAB Coalition (N3C). The meeting will bring together early-stage investigators, established investigators from CFARs and ARCs, community representatives, and NIH program officials, will be fully aligned with the OAR and EHE research priorities, and will disseminate and critique cutting edge HIV science. SBSRN 2025 will begin with a day devoted to mentoring ESIs followed by a one-day scientific symposium and will provide attendees with opportunities for networking and collaboration development.

PI_NAMEs: COLLMAN, RONALD G (contact)

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Basic Science;Behavioral;behavioral and social science;Behavioral Sciences;Clinical Sciences;Collaborations;Communities;community advisory board;community engagement;community research;cost;Country;Critiques;design;Development;Discipline;ethnic minority;Ethnic Population;Evaluation;experience;Feedback;Funding;Future;Goals;Grant;Historically Black Colleges and Universities;HIV;HIV/AIDS;Human Resources;insight;Leadership;Location;Maryland;meetings;member;Mentors;National Institute of Child Health and Human Development;National Institute of Drug Abuse;National Institute of Mental Health;NIH Office of AIDS Research;Participant;peer;Persons;Prevention Research;Process;programs;Publishing;racial minority;racial population;Reporting;Request for Applications;Research;Research Personnel;Research Priority;Resource Sharing;Role;Science;Scientist;social;Social Sciences;substance use;success;symposium;Time;Travel;treatment research;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Penn - Center for AIDS Research - Inter-CFAR Meeting: Social and Behavioral Sciences Research Network


ORG_CITY: WASHINGTON

ORG_NAME: NATIONAL ACADEMY OF SCIENCES

ORG_STATE: DC

PHR: Project Narrative Understanding how the nervous system develops, functions, ages, and interacts with the environment—in both health and disease—and developing safe and efficacious interventions for nervous system disorders are deeply challenging. Many federal agencies are involved in this endeavor, including the National Institutes of Health, the Food and Drug Administration, the National Science Foundation, the Department of Veterans Affairs, and the Department of Defense, as well as academic institutions, private sector companies, disease-focused organizations, and philanthropic foundations, both in the United States and worldwide. The National Academies of Sciences, Engineering, and Medicine’s Forum on Neuroscience and Nervous System Disorders provides a neutral venue for leaders from across these groups to exchange information, ideas, and differing perspectives, with ultimate goal of contributing to accelerating the pace of discovery in neuroscience research and the development of therapies for nervous system disorders.

PI_NAMEs: POSEY NORRIS, SHEENA MARIA (contact)

PROGRAM_OFFICER_NAME: SCOTT, KELLIE

PROJECT_TITLE: Forum on Neuroscience and Nervous System Disorders Proposal

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDRH-T (01)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Eczema / Atopic Dermatitis;Machine Learning and Artificial Intelligence;Psoriasis;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Psoriasis and atopic dermatitis are chronic inflammatory skin diseases that are influenced by environmental exposures. There is a need to develop better approaches monitor the human exposome remotely. In this diversity supplement proposal, we use a novel non-invasive liquid biopsy approach and cutting-edge bioinformatics methods to identify dysregulated pathways and biomarkers in psoriasis and atopic dermatitis.

PI_NAMEs: LIAO, WILSON  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Atopic Dermatitis;Bioinformatics;Biological Markers;chronic inflammatory skin;Collection;Cutaneous;Environmental Exposure;Environmental Risk Factor;Guidelines;Home;Human;Immune;Immunobiology;Inflammatory;Knowledge;liquid biopsy;Machine Learning;Mediating;Methods;Monitor;multiple omics;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;parent grant;Pathway interactions;Patients;Psoriasis;remote monitoring;Research;Skin;skin disorder;Technology

PROJECT_TITLE: Exposome Monitoring for Skin Diseases through Liquid Biopsy Multiomics


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE This administrative supplement proposal seeks to expand the Latino Colorectal Cancer Consortium, a multi- institutional effort to build research infrastructure and study biological contributors to colorectal cancer disparities experienced in the U.S. Latino population by increasing representation from Latino individuals residing in the Midwest and southeast Florida. Evidence suggests that Puerto Rican and Cuban Latino individuals (prominent communities in these two regions) experience worse CRC mortality than Mexican Latino and non-Hispanic white individuals, and this study will permit examination of differences in immune responses that may impact these adverse clinical outcomes. This study will create an opportunity to study how within-group heterogeneity contributes to disparate CRC outcomes with novel molecular and epidemiologic data that will be expeditiously shared with the scientific community.

PI_NAMEs: SCHMIT, STEPHANIE L. (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Administrative Supplement;Age;Alternative Splicing;anti-cancer research;Area;Awareness;Biological;Biological Factors;Biological Markers;Blood;Body mass index;Budgets;Cancer Etiology;cancer health disparity;Characteristics;Clinic;Clinical;cohort;Collection;Colorectal Cancer;Communities;Country;Cuban;Data;data integration;Death Rate;deprivation;Development;Diagnosis;digital pathology;Disparate;Disparity;Disparity population;Dominican;early-career faculty;Elements;epidemiologic data;Epidemiologic Factors;Epidemiology;ethnic disparity;ethnic minority population;Ethnic Origin;Ethnic Population;experience;Family;Florida;Funding;Genetic;Genetic Predisposition to Disease;Genetic study;genomic profiling;Genomics;Germ Lines;Grant;Health;Health behavior;health disparity;health equity;Health Services Accessibility;Heterogeneity;Hispanic;Immune;immune function;Immune response;Immunotherapy;improved;Individual;Institution;Institutional Review Boards;interest;Investigation;Latina;Latino;Latino Population;Latinx;Life Style;Mediating;men;Methodology;Mexican;Midwestern United States;minority scientist;Molecular;mortality;Mutation;Not Hispanic or Latino;novel;Ohio;Outcome;parent grant;parent project;Participant;Pathologic;Patient Recruitments;Patients;Persons;Physical activity;Pilot Projects;Population;prognostic;Protocols documentation;Puerto Rican;Questionnaires;Race;racial minority;racial population;Recording of previous events;recruit;Research;Research Infrastructure;research study;Resources;response;Risk Factors;Saliva;Sampling;Science;Screening for cancer;sex;social;sociodemographic factors;sociodemographics;Somatic Mutation;South American;Spanish;Subgroup;Surveys;survival outcome;T cell response;T-Lymphocyte;Time;Tissue Procurements;tumor;Tumor Tissue;Underrepresented Minority;Woman;Work

PROJECT_TITLE: Investigation of within-Latino heterogeneity in colorectal cancer mutational and T cell profiles

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Antimicrobial Resistance;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - B;Immunization;Infectious Diseases;Liver Disease;Orphan Drug;Pediatric;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative The NIH established collaborative HIV/AIDS Clinical Trials Networks to advance the science of HIV prevention and treatment and to contribute to the end of the HIV epidemic. The UNC Global HIV Treatment and Prevention Clinical Trials Unit will contribute to the work of all four NIH HIV Clinical Trials Networks by enrolling those populations most affected by HIV and by providing innovate scientific leadership and by contributing to the leadership of the networks.

PI_NAMEs: ERON, JOSEPH J (contact);HOSSEINIPOUR, MINA CHRISTINE;WOHL, DAVID A

PROGRAM_OFFICER_NAME: GUBB, STEPHANIE MAJER

PROJECT_TERMS: acute infection;Adherence;Adolescent;adolescent woman;Adult;Affect;Africa;African;AIDS prevention;antiretroviral therapy;Area;black women;Caring;Cells;Child;Childhood;Clinical;Clinical Investigator;Clinical Research;clinical research site;Clinical Treatment;Clinical Trials;Clinical Trials Network;Clinical Trials Support Unit;Clinical Trials Unit;co-infection;Collaborations;Communication;Communities;community engagement;comorbidity;Complex;data management;Dedications;Development;Disease remission;Doctor of Philosophy;Drug Kinetics;Drug resistance in tuberculosis;early phase trial;Enrollment;Epidemic;experience;Female Adolescents;follow-up;gender diversity;Goals;Hepatitis B;Hepatitis B Virus;high risk;high risk population;HIV;HIV Antibodies;HIV drug resistance;HIV vaccine;HIV/AIDS;HIV/TB;Incidence;Individual;Infant;Injecting drug user;innovation;International;Intervention;Investigation;Laboratories;Lead;Leadership;Malawi;men of color;men who have sex with men;Mind;Mother-to-child HIV transmission;National Institute of Allergy and Infectious Disease;Newly Diagnosed;North Carolina;novel;Nucleosides;organizational structure;Participant;participant retention;pathogen;Patient Recruitments;Pharmaceutical Preparations;Pharmacy facility;Phase;phase 3 study;Population;Populations at Risk;Positioning Attribute;pre-exposure prophylaxis;pregnant;Pregnant Women;Prevention;prevention clinical trial;Prevention trial;Principal Investigator;Prisoner;Public Health;Race;Recording of previous events;recruit;Research;Research Personnel;Risk;Sampling;Science;Scientist;Senior Scientist;skills;Southeastern Asia;Southern Africa;Talents;Testing;Therapeutic;Therapeutic Clinical Trial;transgender women;translational scientist;treatment as prevention;treatment trial;Tuberculosis;Tuberculosis Vaccines;United States National Institutes of Health;Universities;Vaccine Clinical Trial;vaccine trial;Vaccines;Vietnam;viral rebound;virtual;Virus;Virus Activation;volunteer;Work;young man;young men who have sex with men;young woman

PROJECT_TITLE: University of North Carolina Global HIV Prevention and Treatment Clinical Trials Unit 2024 Supplement


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Infertility;Maternal Health;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Dilation & curettage (D&C) is one of the most common surgical procedures performed on women throughout the World, with resulting intrauterine fibrosis developing in ~40% of women who undergo D&C in the postpartum (6wk period after birth), but is very rare after D&C in nonpregnant women (<1%). While stem/progenitor cells are crucial for endometrial repair, the role of these cells and underlying molecular mechanisms in this susceptibility of the endometrium to fibrosis and abnormal repair are unknown. This work will have an important impact on the reproductive field by revealing mechanisms underlying abnormal uterine repair, and on the medical field at large by providing insights into the body’s physiological anti-fibrotic wound healing mechanisms, leading to a deeper understanding of the pathogenesis of fatal idiopathic fibrotic diseases in other organs.

PI_NAMEs: TAL, RESHEF  (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Ablation;Adhesions;Adult;Affect;Archives;Asherman Syndrome;Bar Codes;Biology;Birth;Cell Aging;Cell Communication;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cicatrix;Cre-LoxP;Dangerousness;Data;Development;Dilatation and Curettage;Disease;Endometrial;Endometrium;Event;exhaustion;Fertility;Fibroblasts;Fibrosis;Functional disorder;Gene Expression Profile;Genetic;Goals;Habitual Abortion;Heart;Human;iatrogenic injury;idiopathic pulmonary fibrosis;Immunofluorescence Immunologic;Immunohistochemistry;In Vitro;in vitro Assay;Infertility;Injury;innovation;insight;Knowledge;Liver;Lung;Mechanics;Medical;Menstrual cycle;Mesenchymal Stem Cells;Modeling;Molecular;mouse model;multiple omics;Mus;National Institute of Child Health and Human Development;Natural regeneration;new therapeutic target;novel;Operative Surgical Procedures;Organ;Pathogenesis;Pathway interactions;Patients;Physiological;Play;Population;Postpartum Period;Predisposition;Pregnancy;Pregnancy Complications;Pregnancy loss;Premature Birth;prevent;Prevention;profibrotic fibroblast;Property;Proteins;Recurrence;repaired;Reporter;reproductive;Research Priority;response;response to injury;Role;senescence;sequencing platform;single cell technology;single-cell RNA sequencing;Specimen;stem cells;stemness;System;Time;tissue mapping;Tissues;transcriptome;Trauma;Uterus;Woman;Work;wound healing

PROJECT_TITLE: THE ROLE OF MESENCHYMAL PROGENITOR CELLS IN ABNORMAL UTERINE REPAIR

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Nutrition;Sleep Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Alzheimer’s disease is a pressing healthcare issue for our healthcare system and the more than five million patients and families affected by the disease. This research will help understand how changes in the circadian clock contribute to worsening neuronal function, contributing to our understanding of the disease’s cause and potentially uncovering new strategies for prevention or treatment.

PI_NAMEs: GAMBLE, KAREN L;ROBERSON, ERIK D (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Ablation;Affect;Alabama;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloidosis;Animal Model;Animals;Area;ARNTL gene;Autophagocytosis;Behavioral;Bioinformatics;Biology;career development;Cell Physiology;Cells;Chronobiology;Chronotherapy;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;cognitive function;college;Data;Dendritic Spines;dentate gyrus;Development;Development Plans;disadvantaged background;Disease;Diurnal Rhythm;Education;Effectiveness;Electroencephalography;Ensure;epileptiform;Event;excitatory neuron;Excitatory Postsynaptic Potentials;experience;experimental study;Family;Fasting;Fatigue;feeding;Functional disorder;Funding;Future;Gambling;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Government;Grant;Healthcare;Healthcare Systems;High Fat Diet;high school;Household;Impaired cognition;Impairment;improved;inhibitory neuron;innovation;insight;Interneurons;Internships;Intervention;Investigation;knock-down;Laboratories;Learning;Light;LoxP-flanked allele;Medical;Medicine;Membrane;Minority;Molecular;molecular clock;Morphogenesis;mouse model;multiple sclerosis patient;Mus;neural;Neurofibrillary Tangles;neuronal excitability;Neurons;Ontology;Operative Surgical Procedures;parent project;Parents;Parvalbumins;Pathogenesis;Pathology;Pathway interactions;patient population;Patients;Pattern;Periodicity;Personal Satisfaction;pharmacologic;Phase;Physiology;Positioning Attribute;Predisposition;prevent;Prevention strategy;Property;Prosencephalon;Protocols documentation;Recovery;Research;Research Training;Resources;Scholars Program;Scholarship;Science;Scientist;Seizures;Siblings;Single Parent;Sleep;Students;success;symptomatic improvement;Symptoms;synaptic function;Synaptic plasticity;Testing;Time-restricted feeding;tool;Transcript;transcriptome sequencing;Universities;Variant

PROJECT_TITLE: Circadian changes in network excitability and Alzheimer disease pathogenesis


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Complementary and Integrative Health;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Metabolism of glucose and amino acids is critical to the growth of many cancers, including glioblastoma, but treatments to target tumor metabolism remain under-studied. I have identified a susceptibility pathway to the amino acid, cysteine, in glioblastoma, and treatment of glioblastoma cells with cysteine compounds causes glioblastoma cell death, particularly in the setting of glucose deprivation. The proposed research will define the mechanism by which cysteine induces glucose dependence and will use animal models of glioblastoma to validate the use of cysteine therapy combined with a very low carbohydrate (ketogenic) diet as well as radiation and chemotherapy for glioblastoma. 1

PI_NAMEs: NOCH, EVAN K. (contact)

PROJECT_TERMS: Acetylcysteine;Advisory Committees;Amino Acids;Animal Model;Antibiotics;Biological Markers;Biology;Blood Glucose;cancer cell;Carbohydrates;career;career development;Ceftriaxone;Cell Death;Cell Line;Cells;Chemotherapy and/or radiation;clinical development;Clinical Trials;combinatorial;Combined Modality Therapy;Cysteine;Cysteine Metabolism Pathway;Cystine;cytotoxic;cytotoxicity;Data;Dependence;deprivation;Development Plans;Diet;Drug Metabolic Detoxication;early phase clinical trial;Effectiveness;efficacy testing;Electron Transport;Environment;enzyme activity;Exhibits;extracellular;Foundations;Funding;Future;Gene Expression;Glioblastoma;Glioma;glioma cell line;Glucose;glucose metabolism;glucose uptake;Glutamates;Glutathione;Goals;Growth;Homocysteine;Human;Hydrogen Peroxide;Hypoglycemic Agents;Hypoxia;Image;improved;in vivo;Institution;International;Intervention;Investments;Junior Physician;ketogenic diet;ketogentic;luciferin;Malignant Neoplasms;Measures;Mediating;Medicine;Mentors;Mentorship;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methionine Metabolism Pathway;Mitochondria;molecular imaging;mouse model;Mus;NADP;neoplastic cell;neuro-oncology;Neurology;neurotoxicity;Normal tissue morphology;novel;novel therapeutic intervention;Oncologist;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Patients;Pentosephosphate Pathway;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;Physicians;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;precision medicine;Predisposition;Production;professor;Pyruvate;Radiation;Reactive Oxygen Species;Reducing diet;Research;Research Personnel;response;Role;Science;Scientist;Secure;skills;spheroids;Stress;synergism;System;temozolomide;Testing;The Cancer Genome Atlas;Toxic effect;Training;Transgenic Organisms;Translating;translational approach;Translations;Treatment Efficacy;tumor;Tumor Escape;tumor metabolism;Tumor Tissue;United States National Institutes of Health;Up-Regulation;uptake;Work;Xenograft procedure

PROJECT_TITLE: Targeting Cysteine Susceptibility in Glioblastoma


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

ORG_STATE: MD

PHR: Project Narrative Ref: Grant Number: 5UM1AI108568-11 Principal Investigator: Merlin Robb, MD, PhD Project Title: The Military HIV Research Program (MHRP) Clinical Trial Unit Subject: Supplemental Funding Identifying individuals with multidrug resistant TB is the critical first step in PHOENIx MDR TB. It is often the case that these cases and their families are located at some distance from the CRS clinic and participants are currently being evaluated at the nearest Kenyan health clinic. In order to efficiently maintain all required research activities, the KEMRI WRP site (CRS 12501) and Moi University Clinical Research Center (MUCRC) are requesting purchase of a van configured to permit all activities required for the PHOENIx study visit to include phlebotomy, storage of blood tubes pending processing at the main CRS laboratory. Both the Kericho and Moi site will require these vans to obviate the use of peripheral health clinics and accommodate the wide geographic dispersion of PHOENIx participants.

PI_NAMEs: AKE, JULIE A.;ROBB, MERLIN L (contact)

PROGRAM_OFFICER_NAME: ROBY, GREGG A,

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Africa;Blood;Budgets;Clinic;Clinical Research;clinical research site;Clinical Trials Unit;Doctor of Philosophy;Domestic Partners;Electronic Mail;Family;Foundations;Funding;Geography;Grant;Health;HIV;Individual;Laboratories;Lead;Military Medicine;Military Personnel;Multidrug-Resistant Tuberculosis;Neurofibromin 2;Participant;Peripheral;Principal Investigator;programs;Research;Research Activity;Site;Specialist;Tube;Universities;Vendor;Venous blood sampling;Visit


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: FAIRFAX

ORG_NAME: ICF, INC., LLC

ORG_STATE: VA

PI_NAMEs: LEAHY, ERIN  (contact)

PROJECT_TERMS: Affect;Cancer Control;Cessation of life;Division of Cancer Control and Population Sciences;Grant;Incidence;Malignant Neoplasms;Mission;Morbidity - disease rate;National Cancer Institute;operation;Population Sciences;programs;Qualifying;quality of life for cancer survivors;Recurrence;Research;Risk Reduction;Scientific Advances and Accomplishments;Services;tool

PROJECT_TITLE: PROJECT MANAGEMENT, TECHNICAL, COMPUTING, AND ADMINISTRATIVE SUPPORT SERVICES FOR THE DIVISION OF CANCER CONTROL AND POPULATION SCIENCES (DCCPS)


ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PI_NAMEs: GADDIS, NATHAN  (contact)

PROJECT_TERMS: Area;Bioinformatics;Data Analytics;genome wide association study;tool development

PROJECT_TITLE: DATA ANALYTICS, STATISTICAL AND BIOINFORMATIC ANALYSIS AND TOOL DEVELOPMENT, Genome wide association studies (GWAS)


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Radiation Oncology;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: While radiation is a major treatment modality used in the management of oral squamous cell carcinoma (OSCC), a significant proportion of patients, particularly those with more advanced disease, fail to respond to therapy; thus, resulting in poor patients' outcomes and the urgent need to identify an appropriate sensitizer. We have identified thyroid hormone receptor interacting protein 13 (TRIP13) as a key player in modulating response to radiation, based on its role in promoting non-homologous end joining (NHEJ). The main objective of this work is to understand the molecular mechanisms underlying TRIP13-mediated NHEJ, with the goal of providing rationale for a mechanism-based therapy to sensitize OSCC to radiation, and utilize activation status of this protein as a predictive marker of response to radiation therapy.

PI_NAMEs: HUTCHINSON, MARSHA-KAY NORISSA DEANNA (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Address;advanced disease;aggressive therapy;Antibodies;ATP phosphohydrolase;ATPase Domain;Attenuated;Binding;Biological;Cell Line;Cell Survival;Cetuximab;Complex;cytotoxic;Data;Disease;DNA;DNA Damage;DNA-dependent protein kinase;Double Strand Break Repair;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Exposure to;Failure;FDA approved;Genetic Engineering;genetically modified cells;Goals;Human Cell Line;Hydrolysis;Immunohistochemistry;Impairment;improved;In Vitro;in vivo;Incidence;insight;Investigation;irradiation;Knowledge;Laboratories;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Modality;Molecular;mouth squamous cell carcinoma;Mus;Mutation;neoplastic cell;Nonhomologous DNA End Joining;novel;novel strategies;Oncogenic;overexpression;Pathway interactions;patient prognosis;Patient-Focused Outcomes;Patients;Peptides;Phosphorylation;Pilot Projects;predictive marker;Proteins;Radiation;Radiation Induced DNA Damage;Radiation induced double strand break;radiation resistance;radiation response;Radiation therapy;Radiation Tolerance;Radiation-Sensitizing Agents;radioresistant;Receptor-Interacting Protein;Recurrence;Recurrent tumor;repaired;Role;Site;Survival Rate;Testing;Thyroid Hormone Receptor;tumor;Western Blotting;Work

PROJECT_TITLE: Elucidating the Molecular Mechanism of TRIP13-mediated Radiation Resistance in Oral Squamous Cell Carcinoma

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: LOGAN

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PI_NAMEs: HURST, BRETT  (contact)

PROJECT_TERMS: Advanced Development;Anti-viral Agents;Biological Assay;Cell Line;Contracts;Development;In Vitro;in vitro testing;Maintenance;Orthobunyavirus;Paramyxovirus;pathogen;screening;therapeutic development;Viral;Virus

PROJECT_TITLE: Task B22: Comprehensive In Vitro Antiviral Screening Against BSL-4 Pathogens


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PI_NAMEs: BEASLEY, DAVID  (contact)

PROJECT_TERMS: Animal Model;Contracts;Development;Evaluation;infectious disease model;medical countermeasure;Nipah Virus;therapeutic development;Virus Diseases

PROJECT_TITLE: Task A90: Establishment of a Small Animal Model of Nipah Virus (NiV) Infection for Assessment of Medical Countermeasures Efficacy


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Chronic Obstructive Pulmonary Disease;Clinical Research;Health Services;Lung;Machine Learning and Artificial Intelligence;Prevention;Primary Health Care;Telehealth

ORG_CITY: LOUISVILLE

ORG_NAME: TELE-STETHOSCOPE INC.

ORG_STATE: KY

PHR: The research supports development of technology that allows ordinary mobile phones to be used to detect COPD in patients remotely. The intent is to improve early detection of the disease in frontline medicine, thereby improving outcomes and lowering healthcare costs. The technology is scientifically important in that it relies on dynamics modeling rather than lung capacity evaluation or imaging and employs a novel, rigorous approach to AI.

PI_NAMEs: WOLFSON, DAVID  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acoustics;Air;Algorithms;Area;artificial intelligence algorithm;Auscultation;Cardiopulmonary;Cellular Phone;Chronic Obstructive Pulmonary Disease;Classification;Clinical;COVID-19 detection;Data;Devices;Diagnosis;Diagnostic;Disease;Early Diagnosis;Echocardiography;EFRAC;Emergency Medicine;Evaluation;Failure;Frequencies;Funding;Health Care Costs;Heart;hemodynamics;Hospitals;human study;Image;improved;improved outcome;innovation;Legal patent;Logistic Regressions;Lung;Lung Capacity;Medicine;microphone;Modeling;neural network;new technology;novel;novel strategies;Organ;Outcome;Patient Recruitments;Patients;Performance;Phase;Physical Examination;Physicians;Physics;Primary Care;Primary Care Physician;Publishing;Pulmonology;recruit;Research;Research Support;respiratory;Running;Schedule;Side;Specificity;Stethoscopes;success;Talents;Technology;technology development;telehealth;Telephone;Testing

PROJECT_TITLE: A breakthrough mobile phone technology that aids in early detection of COPD - TABA fund supplement


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Emergency Care;Heart Disease;Pediatric

ORG_CITY: PIKESVILLE

ORG_NAME: CORAM TECHNOLOGIES, INC.

PHR: NARRATIVE – STTR PHASE II Cardiac arrest kills hundreds of thousands of Americans each year, but survival is improved with bystander cardiopulmonary resuscitation (CPR). CPR is required by law to be taught in most U.S. high schools, but instructional methods are outdated, non-standardized, and ineffective. Building on the success of our Phase I prototype, we propose finalizing for commercial production a novel, interactive CPR video game experience that combines the drama of a live-action cardiac arrest film with a "CPR Spring" device, to improve learning of CPR skills that should translate into improved survival from cardiac arrest.

PI_NAMEs: TOFT, LORREL ELIZABETH BROWN (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: Address;Affect;American;Auditory;Cardiopulmonary Resuscitation;Chest;Computers;cost;Data;Devices;digital;digital media;Drama;Educational process of instructing;Emotional;experience;Feedback;Female;Film;gender disparity;Goals;Grant;handheld mobile device;Heart Arrest;high school;High School Student;Human;improved;Instruction;instructor;Laws;Learning;Manikins;Methods;Modernization;multisensory;North America;novel;out-of-hospital cardiac arrest;Outcome;Persons;Phase;Play;Production;Property;prototype;Reporting;response;Schools;skill acquisition;skills;Small Business Technology Transfer Research;Students;success;Tactile;teacher;Teaching Method;Time;Training;Translating;Video Games;Visual;wireless communication;wireless fidelity

PROJECT_TITLE: Using Interactive Digital Media to Teach Cardiopulmonary Resuscitation to High School Students


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PI_NAMEs: PATTERSON, THOMAS  (contact)

PROJECT_TERMS: Advanced Development;anti-fungal agents;Biological Assay;combat;Contracts;Development;Disease;fungus;In Vitro;in vitro testing;Maintenance;pathogen;screening;therapeutic development;Toxin

PROJECT_TITLE: Task A26: In Vitro Screening for Antifungal Activity Against Fungal Disease Pathogens


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

ORG_STATE: CA

PI_NAMEs: MIRASILAS, JON  (contact)

PROJECT_TERMS: Antibiotic Resistance;Antibodies;Antimicrobial Resistance;Biological;Chemistry;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Development;Development Plans;Drug Kinetics;Evaluation;Gram-Negative Bacteria;In Vitro;in vivo;Interventional Agent Development;Lead;manufacture;pathogen;pre-clinical;product development;programs;Safety;Services;Therapeutic;therapeutic development;Toxicology;Toxin;Update

PROJECT_TITLE: Task A07: Updating Generic Version of Product Development Plan for Monoclonal Antibiotic-Resistant Antibodies


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases

PROJECT_TERMS: Biological;Chemistry;Communicable Diseases;Development;Development Plans;Drug Kinetics;Evaluation;In Vitro;in vivo;Interventional Agent Development;Lead;manufacture;Monoclonal Antibodies;pathogen;pre-clinical;product development;programs;Safety;Services;Therapeutic;therapeutic development;Toxicology;Toxin;Update

PROJECT_TITLE: Task A07: Updating Generic Version of Product Development Plan for Monoclonal Antibodies


PROJECT_TERMS: Biological;Chemistry;Communicable Diseases;Development;Development Plans;Drug Kinetics;Evaluation;In Vitro;in vivo;Interventional Agent Development;Lead;manufacture;pathogen;pre-clinical;product development;programs;Safety;Services;Therapeutic;therapeutic development;Toxicology;Toxin

PROJECT_TITLE: Task C23: Continuation of Oxfendazole Stability Studies


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: MANASSAS

ORG_NAME: AMERICAN TYPE CULTURE COLLECTION

PI_NAMEs: RASHID, SUJATHA  (contact)

PROJECT_TERMS: Antimicrobial Resistance;Basic Science;biological research;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Communities;Contracts;Emerging Communicable Diseases;Gram-Negative Bacteria;Gram-Positive Bacteria;Microbiology;National Institute of Allergy and Infectious Disease;pathogen;preservation;priority pathogen;product development;Production;Reagent;repository;Research;Research Activity;research and development;Resources

PROJECT_TITLE: Microbiology and Infectious Diseases Biological Research Repository (MID-BRR): AMR Research Activities


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: Basic Science;biological research;Communicable Diseases;Communities;Contracts;Emerging Communicable Diseases;Microbiology;National Institute of Allergy and Infectious Disease;pathogen;preservation;priority pathogen;product development;Production;Reagent;repository;Research;research and development;Resources

PROJECT_TITLE: Microbiology and Infectious Diseases Biological Research Repository (MID-BRR)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PROJECT_TERMS: Basic Science;biological research;Communicable Diseases;Communities;Contracts;Emerging Communicable Diseases;Influenza;Microbiology;National Institute of Allergy and Infectious Disease;pathogen;preservation;priority pathogen;product development;Production;Reagent;repository;Research;Research Activity;research and development;Resources;universal influenza vaccine

PROJECT_TITLE: Microbiology and Infectious Diseases Biological Research Repository (MID-BRR): Universal Influenza Vaccine Research Activities


ORG_CITY: DESSAU-ROSSLAU

ORG_COUNTRY: GERMANY

ORG_FIPS: GM

ORG_NAME: IDT BIOLOGIKA GMBH

PI_NAMEs: TRUSHEIM, HEIDI  (contact)

PROJECT_TERMS: Adjuvant;Bacterial Drug Resistance;Biological Products;cell bank;Clinical Research;Communicable Diseases;Contracts;COVID-19 vaccine;Cyclic GMP;Development;Development Plans;manufacture;next generation;novel vaccines;pathogen;Phase;product development;Services;System;United States Food and Drug Administration;vaccine delivery;vaccine development;Vaccines

PROJECT_TITLE: Task V34: Master Cell Banks Manufacturing for Next Generation SARS-CoV-2 Vaccines


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Within couples where both members smoke (i.e., dual-smoker couple), little attention has been paid to understanding the unique needs of sexual and/or gender minority (SGM) couples (i.e., couples with at least one individual identifying as SGM). Although SGM groups remain underrepresented in research, evidence strongly suggests they experience a disproportionate cancer burden, with tobacco being a leading cause of preventable disease and death among SGM groups. Using both quantitative and qualitative methodology, we will examine heterogeneity in the experiences of SGM people who smoke and are in a dual-smoker couple relationship to inform future work investigating heterogeneity in SGM experiences during cessation and the development of cessation interventions tailored for SGM people who have smoking partners.

PI_NAMEs: VANDELLEN, MICHELLE RENEE (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Abstinence;Attention;Automobile Driving;Awareness;Behavior;Cancer Burden;Cessation of life;Code;cost effectiveness;Couples;Data;Development;Disease;Disparity;efficacy evaluation;Environmental Risk Factor;evidence base;experience;financial incentive;Future;Gender Identity;gender minority;Heterogeneity;improved;Impulsive Behavior;Impulsivity;Individual;interest;Intervention;Interview;Knowledge;Malignant Neoplasms;Measures;member;Methodology;Methods;Motivation;Outcome;parent project;Parents;Persons;preference;Randomized, Controlled Trials;recruit;Research;response;Sampling;Sex Orientation;sexual identity;sexual minority;Side;Smoke;Smoker;Smoking;Smoking Behavior;smoking cessation;social;stressor;Structure;Surveys;Tobacco;Work

PROJECT_TITLE: Randomized Controlled Trial of Dyadic Financial Incentive Treatment for Dual Smoker Couples: Evaluation of Efficacy, Mechanisms, and Cost Effectiveness

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE OVERALL Alzheimer’s disease (AD) affects an estimated 5.8 million Americans, with patient numbers expected to triple over the next 30 years, yet there is no cure. There is an urgent need to stop, prevent, and treat AD. By establishing marmoset models of AD, we will be able to investigate primate-specific cellular and molecular root causes that underlie the pathogenesis and progression of AD and support future translational studies to accelerate the pace of bringing therapies to patients.

PI_NAMEs: CARTER, GREGORY W;RIZZO, STACEY J;SILVA, AFONSO C (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Acceleration;Affect;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;American;animal care;animal model development;Behavioral;Bioinformatics;Biological Assay;Biology of Aging;Callithrix;Clinical Protocols;Cognitive;Communities;comparative;data dissemination;data resource;Dedications;Disease;Disease Progression;Early Onset Alzheimer Disease;Event;Fibroblasts;Future;gene editing technology;Genes;Genetic;Genetic Diseases;Genetic Engineering;Genetic Risk;genomic signature;Genomics;Goals;Human;in vivo;Intervention;Investigation;Knowledge;Late Onset Alzheimer Disease;Life;Modeling;Molecular;multidisciplinary;multimodality;Mutation;Neurodegenerative Disorders;neurodevelopment;neuroimaging;neuropathology;novel;Onset of illness;open data;Pathogenesis;Pathologic;Patients;Phenotype;Population;presenilin-1;prevent;Primates;Process;Protocols documentation;Research;Research Project Grants;Resource Sharing;Resources;risk variant;Study models;Therapeutic;translational study;Validation

PROJECT_TITLE: U19 MARMO-AD Supplement: Resources for Marmoset Fibroblasts Conversion Pipeline


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Nonalcoholic fatty liver disease (NAFLD), which worsens cardiovascular disease and commonly causes cirrhosis, is the most prevalent cause of liver dysfunction in Western countries. The studies performed herein will be the first to reveal the importance of hepatocyte ketogenesis in regulating the most predictive index of poor prognosis in NAFLD pathogenesis, fibrosis. These studies will quantify how ketogenesis feeds back to regulate mitochondrial oxidative function in the liver, determine how ketone metabolism becomes dysregulated in NAFLD, and provide new potential intervenable metabolic nodes within distinct liver cell compartments to prevent NAFLD complications.

PI_NAMEs: CRAWFORD, PETER A (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Acceleration;Acetoacetates;Acinus organ component;adverse outcome;amino acid metabolism;Back;beta-Hydroxybutyrate;Bioenergetics;blind;Carbohydrates;Carbon;Cardiovascular Diseases;Cell Compartmentation;Cells;Chemicals;Cirrhosis;Citric Acid Cycle;Coenzyme A-Transferases;Compensation;Country;diabetes pathogenesis;Drug Targeting;Electrons;Energy Supply;Equilibrium;Exhibits;experimental study;Fatty acid glycerol esters;fatty liver disease;Feedback;feeding;Feeds;fibrogenesis;Fibrosis;Funding;Genetic;Geography;Health;Hepatic;Hepatic Fibrogenesis;Hepatocyte;High Fat Diet;Homeostasis;Human;Hydroxybutyrates;indexing;Injury;Insulin Resistance;Intervention Studies;intrahepatic;Investigation;Isotopes;ketogenesis;ketogentic;Ketone Bodies;Ketones;Knock-out;Knowledge;Kupffer Cells;Lipids;Liver;Liver diseases;Liver Dysfunction;Liver Fibrosis;liver function;liver injury;Liver Mitochondria;liver transplantation;Macrophage;Malignant neoplasm of liver;Mass Spectrum Analysis;Measurement;Measures;Metabolic;Metabolism;metabolomics;Mitochondria;mitochondrial oxidative dysfunction;Mus;Myeloid Cells;NADH;Nicotinamide adenine dinucleotide;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Nuclear Magnetic Resonance;Observational Study;oxidation;Oxidation-Reduction;Oxidoreductase;Oxygen;Pathogenesis;Pathogenicity;Phylogeny;preservation;prevent;Production;Prognosis;Protons;Proxy;Public Health;Publishing;Reporting;respiratory;Risk;Role;Severities;Signal Transduction;succinyl-coenzyme A;Testing;therapeutic target;Tracer;Transferase;Triglycerides

PROJECT_TITLE: Ketone Body Metabolism and Integrated Metabolic Homeostasis

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOCA RATON

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative  There is some intriguing evidence that changes in the way older individuals carry out a complex activity of daily living may herald the beginning of cognitive decline. One of these complex activities is driving. We propose testing the ability of the increasingly popular sensors placed in cars to track driver behavior (following too close, drifting out of one's lane, distracted driving) to provide early warnings of cognitive decline, allowing the individual time to seek further testing and treatment and to make plans for the future.

PI_NAMEs: NEWMAN, DAVID ;TAPPEN, RUTH M (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Activities of Daily Living;Age;Aging;Algorithms;Alzheimer's Disease;American;Automobile Driving;Awareness;Behavior;Brain;Chronic;Clinical;Cognition;Cognitive;cognitive change;cognitive function;cognitive testing;Complex;Computer software;cost;Data;Databases;Dementia;Detection;Diagnostic;Disease Progression;distracted driving;distraction;driving behavior;Early Diagnosis;Emotional;Enrollment;Evaluation;evaluation/testing;executive function;Exhibits;experience;Family;Future;Gender;Goals;Government;Grouping;human old age (65+);Impaired cognition;indexing;Individual;innovation;interest;Language;Measurable;Measurement;Measures;Medical;Medicare;Memory;Methods;mild cognitive impairment;Modernization;Monitor;older adult;older driver;Older Population;open source;Output;Participant;Performance;Persons;Public Health;recruit;Reporting;Research;Research Project Grants;response;Risk;Safety;screening;screening program;sensor;Services;Societies;Symptoms;System;Techniques;Technology;Testing;Time;Translating;Vehicle crash;Visual attention;Visuospatial;Weather;wellness visit;willingness

PROJECT_TITLE: In-Vehicle Sensors to Detect Cognitive Change in Older Drivers


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: MADISON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Modified Public Health Relevance Section We propose to establish the Midwest Center for Cryo-Electron Tomography (MCCET) at the University of Wisconsin, Madison, a National Service Network Hub for Cryo-Electron Tomography. The MCCET will provide national and international access to state-of-the-art equipment and well-trained technical staff to support the growing need for cryo-ET of biomedically-relevant specimens from isolated macromolecules to tissue from organisms. The MCCET will enable researchers, inside and outside of the national network of service centers, to prepare specimens suitable for on-site cryo-ET data acquisition and data processing, and to train and cross-train in a broad-range of cryo-ET workflows.

PI_NAMEs: WRIGHT, ELIZABETH R (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Administrative Supplement;Administrator;Biochemistry;Biological Sciences;Carbon;Cell Culture Techniques;Complex;computer scientist;computerized data processing;Computers;Cryo-electron tomography;Cryoelectron Microscopy;cryogenics;data acquisition;Data Collection;Database Management Systems;Development;Devices;Discipline;Electron Microscope;Electron Microscopy;Ensure;Equipment;evaporation;experience;Fluorescence;Grant;Human Resources;Image;Image Analysis;image processing;improved;Individual;innovation;Institution;instrumentation;International;Ions;Laboratory culture;Light Microscope;macromolecule;materials science;member;Methods;Midwestern United States;Molecular Biology;operation;Organelles;Organism;Pattern;Postdoctoral Fellow;Preparation;preservation;pressure;public health relevance;Recording of previous events;recruit;Research;Research Personnel;Resources;Robot;Role;Sampling;Scanning;Services;Site;skills;small molecule;Specimen;Standardization;System;Teacher Professional Development;Technology;technology development;Tissues;Training;Training Activity;United States National Institutes of Health;Universities;Validation;virtual;Wisconsin

PROJECT_TITLE: Administrative Supplement: The Midwest Center for Cryo-Electron Tomography

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(51)-R]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE “Understanding regional variation in cancer care delivery and outcomes among American Indian and Alaska Native people” is a one-year study which will use data from the North American Association of Central Cancer Registries Cancer in North America database to examine regional differences in predictors of timely and guideline-concordant cancer care, and cancer survival, among AIAN people. In an exploratory aim, we will also investigate whether these predictors vary between AIAN people living in Purchased/Referred Care Delivery Areas (i.e., counties that are served by or adjacent to IHS facilities) and those that are not. These data will provide critical information to understand causes of AIAN cancer disparities that can be used to drive future structural and programmatic interventions using a local approach, among a population that has often been either excluded from cancer surveillance and health services research for small sample sizes, or treated as one homogeneous population, ignoring known regional heterogeneity.

PI_NAMEs: BURKARD, MARK E (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Address;Affect;Age;Alaska Native;Alaska Native population;American;American Indian Population;American Indians;Area;Behavior;Breast;Budgets;Cancer Burden;cancer care;cancer health disparity;cancer site;cancer survival;cancer therapy;care delivery;care outcomes;Caring;Clinical;Collaborations;Colorectal;Communities;County;Data;data registry;Databases;Diagnosis;Disparate;disparity reduction;Event;evidence base;evidence based guidelines;Exclusion;experience;Future;Goals;Guidelines;health care quality;Health Care Quality Indicators;health care settings;Health Services;Health Services Research;Health system;Healthcare;Heterogeneity;improved;Incidence;Individual;innovation;interest;Intervention;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Managed Care;Measures;Mediating;Mediation;Modeling;Modification;mortality;Neighborhoods;neoplasm registry;North America;Northern Plains;Not Hispanic or Latino;Outcome;outcome prediction;Outcomes Research;Patients;Persons;Population;Prevalence;Quality of Care;regional difference;Research;response;rurality;Sample Size;Services;sex;social;Socioeconomic Status;Staging;structural health determinants;surveillance data;survival disparity;therapy development;Time;Tobacco use;Tribes;United States Indian Health Service;Variant;Work

PROJECT_TITLE: Regional differences in guideline-concordant cancer care and outcomes among American Indian Alaska Native people


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Genetics;Human Genome;Microbiome

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE A fundamental understanding of mechanisms regulating skin barrier function is essential to effectively prevent and manage skin conditions associated with epidermal barrier dysfunction such as, atopic dermatitis, psoriasis, and photoaging. Skin microbiome can improve barrier function and is an untapped resource for developing microbiota-based therapies that can prevent skin diseases. The proposed studies will deepen understanding of skin barrier regulation and lead to identification of microbiota-based therapeutics for preventing skin barrier dysfunction.

PI_NAMEs: UBEROI, AAYUSHI  (contact)

PROJECT_TERMS: Acne;Adhesions;Advisory Committees;Air Pollutants;Allergens;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Atopic Dermatitis;Attenuated;Bioinformatics;career;cell type;commensal microbes;Complex;Coupled;Data Set;Dehydration;design;Disease;Ecology;Ecosystem;efficacy testing;Environment;Environmental Exposure;Epidermis;epithelial repair;Epithelium;Flowers;Functional disorder;Genetic Transcription;Germ Lines;Germ-Free;Gnotobiotic;Goals;high throughput screening;Home;Homeostasis;host microbiome;host microbiota;Human;Immune;improved;In Vitro;Infection;Inflammation;inhibitor;Knock-out;Ligand Binding;Ligands;Mass Spectrum Analysis;Mediating;member;Mentors;metabolomics;metagenomic sequencing;Metagenomics;microbial;microbial community;microbiome;microbiota;Modeling;mouse model;Multiomic Data;multiple omics;Mus;Names;novel therapeutics;pathogen;Pathway interactions;Patients;Pennsylvania;Permeability;Phase;pollutant;Precision therapeutics;Premature aging syndrome;prevent;Probiotics;Psoriasis;Receptor Signaling;Regulation;repaired;Research;resident commensals;Resources;response;Role;Rosacea;sensor;Signal Transduction;skills;Skin;skin barrier;skin disorder;skin microbiome;Skin repair;System;Systems Biology;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Tight Junctions;tool;Training;transcription factor;transcriptome sequencing;transcriptomics;Tryptophan;Tryptophan Metabolism Pathway;Ultraviolet Rays;Universities;UV induced;Xenobiotics

PROJECT_TITLE: Decoding microbial-Aryl Hydrocarbon Receptor interactions at the skin barrier interface

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Genetics;Human Genome;Microbiome

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative New understanding of microbiome communities have shifted paradigms on what determines eukaryotic host health. We seek to understand how microbiomes assemble, what drives microbiome community succession and strain evolution, and how microbiome network structure confers stability and host homeostasis. We seek to understand these question by harnessing the microbiomes of microbes because with this understanding we might gain new insights into how microbiomes fail in disease, ultimately leading to new insights into how microbiomes can be modulated to develop microbiome-based therapeutics.

PI_NAMEs: JACKREL, SARA LINDSAY (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Identifying the Rules Governing Host-Microbiome Composition and Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

PHR: NARRATIVE Informative variability is the key to prediction and therefore it is critical to better understand heterogeneities within underrepresented groups to address current cancer research inequities. We will perform state-of-the-art multi-dimensional transcriptome characterization to describe tumor heterogeneities within three underrepresented groups. We will explore associations between transcriptome variables, risk factors and outcomes to determine possible causes and consequences of within-group differences and provide new avenues to advance equity in cancer prevention, control and outcomes in these underrepresented populations.

PI_NAMEs: ULRICH, CORNELIA M (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Address;Age;anti-cancer research;Area;Biological;Biological Process;Biology;Cancer Patient;cancer prevention;Characteristics;Clinical;Clinical Management;clinical predictors;clinical risk;comorbidity;Companions;Data;Data Element;Data Set;Dimensions;Elements;Environmental Exposure;epidemiologic data;Epidemiology;Equity;Ethnic Origin;Focus Groups;Gene Expression;Gene Expression Profile;gene function;Genetic;Genetic Risk;genetic risk factor;Goals;Hand;health care availability;health management;Hereditary Malignant Neoplasm;Heterogeneity;Hispanic;Hispanic Populations;improved;indexing;Individual;Inequity;insight;interest;Intervention;Isometric Exercise;Knowledge;Life Style;low socioeconomic status;Malignant Neoplasms;Measures;member;Methods;Modeling;Modification;Molecular;multiple datasets;novel;Outcome;Parents;participant enrollment;Patients;Pattern;Population;Population Database;preservation;Principal Component Analysis;prognostic;Recording of previous events;Research;Resolution;Resources;response;Risk;Risk Factors;risk prediction;rural area;sex;Signal Transduction;sociodemographics;socioeconomic disadvantage;socioeconomics;Source;Sum;transcriptome;transcriptome sequencing;transcriptomics;tumor;tumor heterogeneity;Underrepresented Populations;Utah;Work

PROJECT_TITLE: Heterogeneity of tumor transcriptomics in underrepresented populations

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ORG_CITY: BOSTON

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The predoctoral (F99) phase of this proposal will investigate neuromuscular dysfunction when faced with genetic disease, aging and injury, and use gene therapy as a treatment strategy. Neuromuscular decline for all age- related neurodegenerative disorders maybe linked to accelerated biological aging. The K00 portion of this proposal will study cellular reprogramming of the motor unit as a way to improve motor unit longevity and resilience when faced with genetic disease, aging and injury.

PI_NAMEs: RICH, KELLY  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Adult;age acceleration;age related neurodegeneration;aged;Aging;aging mechanism;Biological Aging;career;career development;Cell Aging;cell injury;Cell Reprogramming;cell type;Chronology;Communication;design;Development Plans;Disease;disease phenotype;Epigenetic Process;experience;Foundations;Functional disorder;gene therapy;Genetic;Genetic Diseases;Genetic Predisposition to Disease;genetic variant;Genome;Goals;improved;Individual;Injury;Institution;Link;Longevity;Mediating;Mentorship;Motor;Motor Neurons;Nerve Degeneration;Nervous System;neuromuscular;Outcome;Pathology;Phase;Phenotype;Physiological;Physiology;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Publications;repaired;Research Personnel;resilience;Risk Factors;Science;Scientist;skills;Technical Expertise;tenure track;Testing;Therapeutic;therapy development;Tissues;transcription factor;transcriptomics;transgene delivery;translational research program;treatment strategy;Viral Vector;Work

PROJECT_TITLE: Cellular reprogramming to promote longevity, resilience, and repair in motor unit degeneration


ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive and fatal disease that affects ~180,000 Americans. To date there are very limited treatment options for IPF with many patients requiring lung transplantation as the last resort. Our lab has identified a activation of Sineoculis homeobox homolog 1 (SIX1) and its co-factor eyes absent homolog (EYA) in IPF; however how the SIX1/EYA1 axis modulates lung fibrosis is not known and will be studied in this proposal.

PI_NAMEs: KARMOUTY-QUINTANA, HARRY  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Adult;Affect;age related;alveolar epithelium;alveolar type II cell;American;Attenuated;autocrine;Biological Assay;Bleomycin;Cell Aging;Cell Proliferation;Cell Separation;Cells;Chronic;Cilia;Clinical;cofactor;Complex;Cre lox recombination system;Data;Defect;Deposition;Development;Disease;Disease Progression;DNA Damage;Drug Approval;Embryo;Epithelial Cells;epithelial injury;Epithelium;Etiology;Experimental Models;Extracellular Matrix;Eye;Family;Fibroblasts;Fibrosis;Functional disorder;gain of function;Genes;Genetic Transcription;Homeobox;Homologous Gene;Human;Hyperplasia;idiopathic pulmonary fibrosis;Immunohistochemistry;improved;In Vitro;in vivo;Inflammatory;Injury;Interstitial Lung Diseases;Link;loss of function;Lung;lung development;lung injury;Lung Transplantation;Malignant Neoplasms;Mediating;Mediator;member;Mesenchymal;Messenger RNA;Modeling;Mus;Mutation;nintedanib;novel;novel therapeutics;Organogenesis;overexpression;paracrine;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Pirfenidone;Prevalence;prevent;Process;Production;Prognosis;Proliferating;Protein Isoforms;Proteins;Pulmonary Fibrosis;pulmonary function;Pulmonary Surfactant-Associated Protein C;Role;senescence;senescence associated secretory phenotype;Signal Transduction;Structure of thyroid parafollicular cell;Techniques;Telomere Length Maintenance;TERF1 gene;Testing;transcription factor;Type II Epithelial Receptor Cell;Up-Regulation

PROJECT_TITLE: Sineoculis Homeobox Homolog 1 (Six1) in Pulmonary Fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Breast cancer is the leading cause of cancer death among US Latinas. Latinas are at high risk of obesity and obesity-related diseases, which are associated with poorer cancer outcomes. In a new trial testing culturally- tailored weight loss interventions in Latina breast cancer survivors, we will add new measures to assess social determinants of health and neighborhood characteristics at trial enrollment. We will study how social determinants of health and neighborhood characteristics affect how Latina breast cancer survivors engage with the culturally-tailored weight loss programs and how much weight they lose.

PI_NAMEs: GREENLEE, HEATHER  (contact)

PROGRAM_OFFICER_NAME: AGURS-COLLINS, TANYA

PROJECT_TERMS: Accountability;Address;Administrative Supplement;Affect;anti-cancer research;Assessment tool;Body Weight decreased;Breast Cancer survivor;built environment;California;Cancer Etiology;Cessation of life;Characteristics;Cohort Studies;community advisory board;Community Health;Data;Data Collection;diabetes prevention program;digital;disability;effective intervention;Failure;food insecurity;Funding;Geography;Health;healthy weight;high risk;housing instability;interest;Latina;Latina Population;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Neighborhoods;Noise;Obesity associated disease;obesity risk;Outcome;Pathway interactions;Population Heterogeneity;programs;Questionnaires;recruit;Registries;remote delivery;Research Support;Resources;response;Safety;Screening procedure;SEER Program;Sequential Multiple Assignment Randomized Trial;social;social health determinants;success;Testing;tool;Transportation;trial design;trial enrollment;United States Centers for Medicare and Medicaid Services;walkability;Washington;Weight;weight loss intervention;weight loss program

PROJECT_TITLE: Using a SMART design to evaluate remotely delivered, culturally tailored weight loss interventions among Latina breast cancer survivors

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Copper is an essential trace nutrient important for fundamental processes including respiration, removal of toxic oxygen radicals, cell signaling, and tissue development. Copper is also toxic, and impaired import and distribution is associated with a number of human diseases including Menkes disease, a fatal genetic Cu deficiency that is characterized by severe postnatal developmental defects. These studies focus on gaining a deeper knowledge of how cells balance copper levels during dynamic states like tissue development by focusing on how the copper is prioritized to control the signaling pathways that promote or inhibit development and how expression of genes regulating Cu import and distribution are regulated.

PI_NAMEs: VEST, KATHERINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: ATP phosphohydrolase;Cell Differentiation process;Cells;cofactor;Copper;Data;Defect;Deficiency Diseases;Development;developmental disease;differentiation in vitro;Disease;Equilibrium;Excision;Gene Expression;Genetic;Golgi Apparatus;Growth Factor;Homeostasis;human disease;Impairment;in vivo;Iron;Knowledge;Menkes Kinky Hair Syndrome;Metabolic Pathway;Muscle Fibers;Muscle hypotonia;Mutation;Nerve Degeneration;Neurons;Normal tissue morphology;Oxidative Phosphorylation;Post-Transcriptional Regulation;postnatal;posttranscriptional;prevent;Process;programs;Reactive Oxygen Species;Regulation;Regulatory Pathway;Research;Respiration;RNA;Role;Series;Signal Pathway;Signal Transduction;skeletal muscle differentiation;therapy development;Tissue Differentiation;Tissues;Trace Elements Nutrition;Work

PROJECT_TITLE: Function and regulation of copper in mammalian tissue differentiation

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative The Pde6cfloxSTOPN/Arr3CreERT2 and Gnat2floxSTOPN/Arr3CreERT2 programmable preclinical models will provide a platform on which to test ongoing research studies aimed at increasing restoration of visual function following gene therapy for cone-mediated dystrophies.

PI_NAMEs: TSANG, STEPHEN H (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Address;Adult;Affect;Age;Alleles;alpha Subunit Transducin;American;Animal Model;brain circuitry;career;Cessation of life;Clinical;clinically relevant;Color;Cone;Cone dystrophy;Cre driver;CRISPR/Cas technology;critical period;cyclic nucleotide-gated cation channel;design;Diagnosis;Disease;Engineering;Enrollment;Functional disorder;gene therapy;Gene therapy trial;Genes;Genetic;Genome engineering;Genotype;Goals;GTP-Binding Proteins;guanine nucleotide binding protein;Human;improved;inducible Cre;Mediating;Metabolic;Modeling;Molecular;Mus;Mutation;novel;Nuclear;Ophthalmology;Outcome;Pathologic;Pathway interactions;Patients;Phenotype;phosphodiesterase 6;phosphoric diester hydrolase;photoreceptor degeneration;Photoreceptors;Play;Pre-Clinical Model;Protocols documentation;Reporter;Research;research study;restoration;Retinal Cone;Retinal Degeneration;Retinal Diseases;Retinal Dystrophy;Retinitis Pigmentosa;Rod;Scientist;Study models;Synapses;synaptogenesis;System;Tamoxifen;Techniques;Testing;Therapeutic;Therapeutic Intervention;Time;Translating;Vertebrate Photoreceptors;Vision;visual dysfunction

PROJECT_TITLE: Defining Barriers to Gene Therapy

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: CLEVELAND

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE (from the parent grant 5R01AG058066) Alzheimer disease (AD) and related disorders (ADRD) are the most common causes of cognitive impairment in older individuals, with no effective long-term treatment or prevention. Examining genetic and biomarker profiles of older, cognitively unimpaired individuals will provide insight into AD/ADRD protective biological mechanisms. This will be done leveraging and building on our unique family-based longitudinal cohort of mid- Western Amish individuals.

PI_NAMEs: HAINES, JONATHAN L (contact);PERICAK-VANCE, MARGARET A.;SCOTT, WILLIAM K

PROGRAM_OFFICER_NAME: FENG, LI REBEKAH

PROJECT_TERMS: Acceleration;Affect;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Amish;biobank;Biological;Biological Markers;case control;Case/Control Studies;Clinical Trials;Cognition;Cognitive;cohort;Communities;Data;data repository;Data Set;design;Development;DNA;druggable target;effective therapy;Environmental Risk Factor;experience;Family;Founder Generation;Genes;Genetic;Genetic Variation;genome wide association study;Genomics;Goals;high risk;Impaired cognition;in silico;In Vitro;Indiana;Individual;insight;Longitudinal cohort;Neurodegenerative Disorders;novel;Ohio;Older Population;parent grant;Participant;Plasma;Population;pre-clinical;Prevention;progression marker;protective allele;protective factors;rare variant;Research;Research Design;risk variant;Signal Transduction;Testing;Variant

PROJECT_TITLE: Protective Genetic Varients for Alzheimer Disease in the Amish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(90)]


NIH_SPENDING_CATS: Brain Disorders;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: DETROIT

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE  Age-dependent neurodegeneration is a major health and socioeconomic burden that will worsen as  human lifespan steadily increases. The mechanisms of degeneration initiation and progression remain poorly understood. This proposal centers on identifying common and distinct themes of the biology of the disease of the family of polyglutamine disorders with the goals of: 1) treating them in the clinic and 2) continuing the scientiﬁc and professional development of Dr. Nuga, postdoctoral fellow in the Todi lab.

PI_NAMEs: TODI, SOKOL  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Academia;age related neurodegeneration;age-related disease;Animal Disease Models;Animals;Award;biochemical tools;Biology;Birds;Black race;Cancer Biology;career;Cell Physiology;Cells;Cellular biology;Clinic;comparative;Complement;Complex;Culture Techniques;Data;Dentatorubral-Pallidoluysian Atrophies;Development;Disease;disease model;Doctor of Philosophy;Drosophila genus;Economic Burden;empowerment;Ensure;Eye;Faculty;Family;Family member;Female;fly;Funding;Future;Generations;Genetic;Goals;Growth;health economics;High School Student;Human;Huntington Disease;Individual;Induced Neurons;Informatics;interest;Investigation;Kennedy Syndrome;Laboratories;Learning;Length;life span;Link;Mammalian Cell;medical schools;member;Mentors;Modeling;Molecular;Muscular Atrophy;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroprotection;Pathogenicity;Pathology;Pathway interactions;Patients;pharmacologic;Pharmacology;polyglutamine;Positioning Attribute;Postdoctoral Fellow;Process;protein complex;Proteins;Proteomics;Publications;Research;Research Activity;Scientist;Secure;Series;socioeconomics;spinal and bulbar muscular atrophy;Spinocerebellar Ataxias;Techniques;Therapeutic;Therapeutic Intervention;Training;transcriptome sequencing;transcriptomics;Type 1 Spinocerebellar Ataxia;Universities;Work

PROJECT_TITLE: Common themes of the biology of disease in polyglutamine disorders