NIH_SPENDING_CATS: Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE This research proposal seeks to define how vaccination alters the course of gammaherpesvirus infection in immunocompetent mice, using the murine gammaherpesvirus 68 model system. While there is clear evidence that the immune system can limit gammaherpesvirus-induced infection, the stage at which infection is disrupted and the cell type(s) involved in protection remain poorly defined. By analyzing viral infection and immune parameters associated with control of gammaherpesvirus infection in the context of vaccination, these studies seek to address this gap in knowledge of gammaherpesvirus infection and disease in susceptible populations.

PI_NAMEs: CLAMBEY, ERIC T;VAN DYK, LINDA F. (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;acute infection;adaptive immune response;Address;Adoptive Transfer;Affect;Anti-viral Agents;Antibodies;Attenuated;Attenuated Vaccines;B-Lymphocytes;Biological Models;Cancer Etiology;CD8-Positive T-Lymphocytes;Cell Differentiation process;cell type;Cells;cross immunity;Cues;cytokine;Data;defined contribution;Dendritic Cells;Detection;Development;Disease;DNA Tumor Viruses;Frequencies;gammaherpesvirus;high dimensionality;Human;Human Herpesvirus 4;Human Herpesvirus 8;human pathogen;Immune;Immune Evasion;Immune system;Immunity;Immunocompetent;Immunosuppression;In Vitro;in vivo;Inactivated Vaccines;Individual;infected B cell;Infection;Inflammatory;Innate Immune Response;insight;Integration Host Factors;interest;Interferon Type II;Kaposi Sarcoma;Knowledge;latency-associated nuclear antigen;latent infection;latent nuclear antigen;Lytic Phase;Macrophage;Macrophage Activation;Malignant Neoplasms;Medical;Methods;mouse model;Mus;Myelogenous;Myeloid Cells;Non-Hodgkin's Lymphoma;Oncogenic Viruses;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Population;Predisposition;prevent;Primary Infection;Process;Regulation;Research Proposals;response;Risk;Role;single cell analysis;Stimulus;success;System;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;Training;Tropism;Vaccination;vaccination protocol;vaccine efficacy;vaccine trial;Vaccines;Viral;Virus;Virus Diseases

PROJECT_TITLE: Therapeutic targets in gammaherpesvirus infection

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE We recently published an easy-to-use battery that can predict upcoming reuse events in patients being treated for opioid use disorder (OUD), and we then migrated that battery to a smartphone platform and demonstrated retention and compliance of over 85% in an OUD population. Our analysis of existing clinical trial data suggests that adjusting buprenorphine dosing in response to reuse events reduces relapse rates. Here we propose to: (1) test the hypothesis that our battery can be used to trigger dose adjustments before reuse events and that this has the effect of reducing reuse and relapse in medication-based OUD treatment; (2) examine the willingness of clinicians to employ this strategy; and (3) examine the cost-effectiveness of these adjustments.

PI_NAMEs: GLIMCHER, PAUL W (contact);MURPHY, SEAN M.;ROTROSEN, JOHN P;TOFIGHI, BABAK

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Algorithms;American;Basic Science;behavior prediction;Buprenorphine;Cellular Phone;Clinical Trials;cohort;Contracts;Cost Analysis;cost effectiveness;Cost Measures;Data;Data Analyses;Dose;Dropout;Effectiveness;Event;Eye;Goals;Homelessness;illicit opioid;instrument;Measurement;Methadone;migration;National Institute of Drug Abuse;Opiate Addiction;Opioid;opioid misuse;opioid use;opioid use disorder;Output;Patients;Pharmaceutical Preparations;Physicians;Policies;Population;Probability;Publishing;Recovery;Relapse;response;Surveys;System;Testing;tool;treatment as usual;Treatment Effectiveness;usability;willingness

PROJECT_TITLE: SOAR: Smartphones for Opioid Addiction Recovery

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Social Determinants of Health

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative: Social stress in humans increases the risk for depression resulting in anhedonia—a loss of interest in pleasurable stimuli—which can manifest within social domains and lead to severe social impairments. Mouse models of social stress are useful to better understand the biological underpinnings of stress-impaired social behavior deficits. Our results show that activation of lateral septum in susceptible mice following social defeat occludes social reward and preference promoting social avoidance behavior.

PI_NAMEs: RUSSO, SCOTT JAMES (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Adolescent;Adult;Anhedonia;avoidance behavior;Behavior;Behavioral;Biological;Biological Assay;Brain;brain circuitry;brain dysfunction;Brain region;bullying;cell type;Chronic;Complex;conditioned place preference;Cues;Data;Development;Diagonal Band Nucleus;Dissection;experience;Feeling;Female;Fiber;FOS gene;Fright;gamma-Aminobutyric Acid;Genetic;Histologic;Human;Image;Impairment;In Situ Hybridization;in vivo;interest;Lateral;Link;male;Maps;Measures;Mediating;Mental Depression;Modeling;Molecular;Motivation;mouse model;Mus;neural;neural circuit;Neurons;neuropsychiatry;Neurotensin;novel;Nucleus Accumbens;optogenetics;Pattern;Photometry;Physiological;Population;Predisposition;preference;prevent;Property;Reaction;Research;resilience;response;reward circuitry;Rewards;Risk;Rodent;Rodent Model;Role;Same-sex;Signal Transduction;Slice;social;Social Behavior;Social Conditions;Social Controls;social defeat;Social Interaction;Social isolation;social stress;Stimulus;Stress;Syndrome;Testing;Time;tool;Viral;Work

PROJECT_TITLE: Neural Circuit Mechanisms of Stress-Impaired Social Reward

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative Radiation therapy (RT), a key pillar of cancer management, causes a common, yet often ignored, side effect – immune system suppression (i. e., radiation-induced lymphopenia [RIL]). Severe RIL has been linked to poor cancer treatment outcomes, presumably due to the reduced tumor surveillance by the immune system, thereby increasing disease recurrence and distant metastasis after RT. We propose approaches, strengthened greatly by the Digital Twins for Radiation Oncology supplement, to identify clinical and dosimetric factors that predict the risk and severity of RIL and understand the impact of RIL on the immune diversity and profile as it affects clinical outcomes; to develop models that can accurately predict the risk of RIL line clinical factors; and to use such models in the optimization of radiation dose distributions to mitigate RIL and its impact on outcomes.

PI_NAMEs: HONG, THEODORE S (contact);MOHAN, RADHE

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: Adjuvant;Affect;Amendment;Bathing;Biological Markers;Blood;cancer therapy;Characteristics;chemoradiation;chemotherapy;Clinical;clinical decision-making;Clinical effectiveness;clinical practice;cohort;Confidence Intervals;Data;Data Scientist;Development;digital twin;Disease;Distant Metastasis;Dose;Effectiveness;Esophagus;Feedback;Future;Goals;Heart;Immune;Immune system;Immunologic Surveillance;immunological diversity;Immunosuppression;Immunotherapy;immunotoxicity;improved;Incidence;indexing;individual patient;Institution;Intensity modulated proton therapy;interest;Investigation;Knowledge;Link;Lung;Lymphocyte;Lymphocyte Count;Lymphocyte Depletion;Lymphopenia;Machine Learning;machine learning model;Malignant neoplasm of brain;Malignant neoplasm of esophagus;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;model development;Modeling;Modification;multiscale data;Outcome;parent grant;parent project;Parents;participant enrollment;patient response;Patient-Focused Outcomes;Patients;personalized risk prediction;Phase I Clinical Trials;phase I trial;Photons;Predictive Factor;predictive modeling;prospective;proton therapy;Protons;Radiation;Radiation Dose Unit;radiation mitigation;Radiation Oncologist;Radiation Oncology;radiation risk;Radiation therapy;Radiation Tolerance;Recurrent disease;Research;response;Risk;risk prediction;Severities;side effect;Site;Spleen;System;Testing;Toxic effect;treatment optimization;Treatment outcome;treatment planning;trial planning;tumor;Uncertainty;Update;virtual;Work

PROJECT_TITLE: Digital Twin for Radiation-Induced Immune Suppression Estimation and Reduction


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PUBLIC HEALTH RELEVANCE The proposed research uses ecological momentary assessment (EMA) to characterize patterns of cannabis and tobacco use and co-use in a sample of 150 sexual minority young adults (SMYAs), and the indirect effects of daily minority stressors on associations between sexual orientation sub-groups (bisexual/bisexual+ vs monosexual SMYAs) on single and co-use patterns. Research aimed at understanding the processes and consequences related to cannabis and tobacco use and co-use in this vulnerable group has very high public health significance given the elevated rates of single use of cannabis and tobacco in SMYAs versus their heterosexual peers, the rising ubiquity of cannabis use and co-use with a variety of tobacco products in this age group, and significant changes in cannabis policies (including legal marketing of cannabis products).

PI_NAMEs: COHN, AMY M (contact);ROMM, KATELYN

PROGRAM_OFFICER_NAME: GOGINENI, ARUNDHATI

PROJECT_TERMS: Address;Age;age group;Alcohol consumption;Automobile Driving;Behavioral Mechanisms;Bisexual;Cannabis;cannabis cessation;Cannabis policy;Cannabis retail;cannabis use behavior;Cigar;Cigarette;Cognitive;Consumption;coping;Data;Development;Discrimination;Disparity;Disparity population;Ecological momentary assessment;Electronic cigarette;Emotional;Ethnic Origin;experience;Future;Gays;Gender;General Population;Goals;Health;health disparity;Heterosexuals;hookah;Individual;insight;Intervention;Legal;Lesbian;Lesbian Gay Bisexual Transgender Queer;Liquid substance;Literature;Marijuana Dependence;marijuana use;Mental Health;minority stress;minority stressor;Moods;Nicotine Dependence;non-cigarette tobacco product;novel;Outcome;pansexual;Participant;Pattern;peer;perceived discrimination;Persons;Policies;Population;Process;Psyche structure;Public Health;public health relevance;queer;Race;Reduce health disparities;Relaxation;Reporting;Research;response;Risk;Sampling;sex;Sex Orientation;sexual identity;sexual minority;sexual minority group;Smoking;stressor;Subgroup;substance use;Testing;theories;therapy design;Time;Time Factors;Tobacco;tobacco advertising;tobacco products;Tobacco use;Tobacco Use Cessation;tobacco user;Vaporizer;Vulnerable Populations;young adult

PROJECT_TITLE: Ecological momentary assessment of daily minority stressors and cannabis and tobacco co-use among sexual minority young adults

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Mental Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PI_NAMEs: CHEN, IRVIN S.Y.;KITCHEN, SCOTT G (contact)

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E


NIH_SPENDING_CATS: HIV/AIDS;Human Fetal Tissue;Mental Health


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: RINDGE

ORG_NAME: Q2I, LLC

ORG_STATE: NH

PHR: PROJECT NARRATIVE Nearly 5 million people are on probation and parole supervision. This project will study the effectiveness of the Probation and Reentry Coach App (PARCA) and Justice Team (JT) portal, a technology-based intervention to help justice-involved people (JIP) address opioid use.

PI_NAMEs: TAXMAN, FAYE S (contact)

PROGRAM_OFFICER_NAME: FLOOD, MORRIS

PROJECT_TERMS: acceptability and feasibility;Address;Analgesics;Appointment;Area;Awareness;Caring;Case Manager;Client;Clinical;Communication;Communities;cost;cost comparison;County;criminal behavior;dashboard;Data;design;Development;digital health;digital tool;Disease;Disparate;Effectiveness;effectiveness evaluation;effectiveness study;Environment;Event;experience;Failure;follow-up;General Population;Goals;Health;Health Technology;Heroin;Housing;improved;Individual;insight;Intervention;Interview;Investments;Justice;Learning;Legal patent;Length;Letters;Link;Location;Measures;Medical;medication for opioid use disorder;mobile application;naloxone dispensing;novel;Opioid;opioid use;opioid use disorder;Outcome;overdose prevention;Oxycodone;parole;parolee;Persons;Phase;Population;Positioning Attribute;primary outcome;probation;probationer;Process;Progress Reports;Public Health;Randomized;rearrest;recidivism;recruit;relapse prevention;Research;Resources;retention rate;secondary outcome;Self Management;service providers;Services;sharing platform;Small Business Technology Transfer Research;social health determinants;Substance Addiction;substance use;substance use treatment;success;Supervision;Support Groups;System;Technology;technology intervention;Testing;Texas;Time;treatment program;treatment services;United States;user centered design;Work

PROJECT_TITLE: PARCA (a digital tool) to improve Justice and Health


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse;Women's Health Research

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Over 100 Americans lose their lives to the opioid epidemic each day, demonstrating that this is a critical public health topic. Results from this project will provide an understanding of how brain function relates to opioid consumption. These data have the potential to lead to the development of improved treatments for individuals who suffer from an opioid use disorder.

PI_NAMEs: KAMENS, HELEN M (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Address;Adult;American;Animals;awake;Behavior;Biological Markers;Brain;Brain region;Buprenorphine;Characteristics;Chronic;Consumption;Cross-Sectional Studies;Data;design;Development;Economic Burden;effective therapy;examination questions;Exposure to;Female;Foundations;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;Health;Human;imaging study;improved;Individual;Individual Differences;innovation;Intake;Laboratories;male;men;Meta-Analysis;Methadone;Methodology;Methods;Modeling;Morphine;Mus;neural;neural circuit;neural network;Neurobiology;neuroimaging;neuromechanism;novel;Nucleus Accumbens;Opioid;opioid abuse;Opioid abuser;opioid epidemic;opioid exposure;opioid misuse;opioid overdose;opioid use;opioid use disorder;opioid user;opioid withdrawal;Overdose;Participant;Pharmaceutical Preparations;Prefrontal Cortex;prescription opioid;Public Health;Publishing;Reporting;Research Personnel;Rest;Rodent;secondary analysis;sex;Sex Differences;sex variable;substance use;Techniques;Treatment outcome;United States;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Neural mechanisms underlying opioid consumption


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: CHAPEL HILL

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative We discovered a robust anabolic response in human cartilage that follows a distal-proximal axis gradient (high in the ankle joint and low in the hip joint); this response was modulated by the same master regulators that regulate limb regeneration in animals capable of limb regeneration. This project investigates the origins of these master regulators in synovial cells, the mechanisms involved, and how aging effects these mechanisms in human joint tissue.

PI_NAMEs: HSUEH, MING-FENG  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Age;age effect;age related;Aging;aging population;Animal Model;Animals;Ankle;ankle joint;appendage;Area;Arthritis;Award;Bioinformatics;Biology of Aging;Biometry;career;career development;Cartilage;Cell Separation;cell type;Cells;chronic pain;Clinical Trials;Colon;complex data;Data;Data Analyses;Data Set;Degenerative Disorder;Degenerative polyarthritis;Development;Development Plans;Distal;Educational Status;Educational workshop;Environment;Fibroblasts;fighting;Future;Gene set enrichment analysis;Goals;Health;Hip Joint;Hip region structure;Homeostasis;Human;improved;improved outcome;Incidence;Injury;injury and repair;joint destruction;joint inflammation;joint injury;Joints;Knowledge;limb regeneration;Macrophage;Mediating;meetings;Mentored Research Scientist Development Award;Mentors;Mentorship;MicroRNAs;Molecular;Morbidity - disease rate;Musculoskeletal;Natural regeneration;neutrophil;novel;novel therapeutic intervention;older adult;Older Population;Pathway Analysis;Pathway interactions;Patient-Focused Outcomes;Patients;physically handicapped;Physiology;Population;prevent;Process;professor;Proteins;Proteomics;Quality of life;recruit;regenerative;regenerative therapy;Research;Research Activity;research and development;Research Personnel;resilience;response;Science;Signal Pathway;skill acquisition;skills;Source;statistics;Stress;Sweden;Synovial Cell;Synovial Membrane;T-Lymphocyte;Testing;Therapeutic;therapeutic miRNA;therapy development;Time;Tissues;Training;Training Activity;Translational Research;Universities;Virginia;Work

PROJECT_TITLE: Novel Mechanisms Of MicroRNA-Mediated Anabolic Effects In Age-Related Osteoarthritis

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Women in South Asia, including India, often migrate from their husbands’ home back to their parents’ home in pregnancy and for delivery, which may have implications for maternal and child heath, yet this phenomenon is understudied. We will conduct a multisite longitudinal study in India to understand and describe this phenomenon (which we call temporary childbirth migration) and measure its impact on infant and maternal health, with a primary outcome of preterm birth.

PI_NAMEs: DIAMOND-SMITH, NADIA GRIFFI (contact);EL AYADI, ALISON M

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: affection;Area;Asia;Asian Women;Back;Birth;Breast Feeding;care outcomes;Caring;Cessation of life;Child;Child health care;Childbirth;Coin;Communities;Comprehensive Health Care;Continuity of Patient Care;Contraceptive Agents;cost;Data;Data Collection;data collection site;Dimensions;Disadvantaged;Dose;early pregnancy;Economics;Emotional;Empathy;Ensure;family support;Geography;Health;health care availability;Health Policy;health practice;Healthcare;Heterogeneity;Home;Housekeeping;Husband;improved;India;Infant;Infant Care;Infant Health;infant outcome;Interview;Laws;Left;Longitudinal cohort;Longitudinal Studies;Maternal and Child Health;Maternal Health;maternal morbidity;maternal outcome;Measurement;Measures;Mediator;Medical Records;Migrant;migration;Modeling;mortality;Mothers;National Institute of Child Health and Human Development;neonatal health;Neonatal Mortality;Newborn Infant;Outcome;Parents;Pathway interactions;Pattern;Perinatal Care;perinatal health;perinatal outcomes;perinatal period;perinatal women;Personal Satisfaction;Phase;Policies;postnatal;Postpartum Period;Postpartum Women;Pregnancy;Pregnancy Outcome;Pregnant Women;Premature Birth;Prenatal care;Prevalence;primary outcome;Public Health;recruit;Risk;secondary outcome;Site;Social support;sociodemographic factors;sociodemographics;South Asian;Surveys;time use;uptake;Vaccination;Visit;Woman;Women Status

PROJECT_TITLE: Temporary childbirth migration: understanding the magnitude and implications for maternal and infant health

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Osteoporosis;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Osteoporosis is a prevalent disease in the aging population affecting more than 10 million Americans. Vertebral fractures from osteoporosis have debilitating consequences such as pain and immobility, resulting in substantial socioeconomic burden. This proposal aims to develop a novel quantitative imaging methodology using a clinical photon-counting detector CT system to comprehensively characterize trabecular and cortical bone in the spine, and enable the early detection of compromised bone quality and subsequently facilitate a timely initiation of pharmacologic therapies and monitor patient’s response to such therapies.

PI_NAMEs: BAFFOUR, FRANCIS ;RAJENDRAN, KISHORE  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: 3-Dimensional;Adult;Affect;aged;aging population;American;bone;Bone Density;bone fragility;bone loss;bone mass;bone quality;Cadaver;Clinical;clinical care;clinical practice;clinically significant;cortical bone;Custom;Data;deep learning;denoising;design;Diagnostic;diagnostic strategy;Disease;Distal;Dual-Energy X-Ray Absorptiometry;Early Diagnosis;Economic Burden;Elderly;Evaluation;Fracture;fracture risk;Geometry;Goals;Health Personnel;high risk;Hyperparathyroidism;Image;imaging biomarker;Immobilization;improved;in vivo;Individual;innovation;Intervention;Limb structure;Longitudinal cohort study;Lupus;Measures;meter;Methodology;microCT;Monitor;Morbidity - disease rate;Morphology;morphometry;musculoskeletal imaging;Noise;novel;Osteoporosis;osteoporosis with pathological fracture;Osteoporotic;Pain;Patient Monitoring;patient response;Patients;Peripheral;personalized management;pharmacologic;photon-counting detector;Plasma Cells;Postmenopause;Preparation;Prevention;Property;Protocols documentation;quantitative imaging;Radial;Reference Standards;Reporting;Research;Resolution;Resources;response;Risk;Roentgen Rays;Screening procedure;segmentation algorithm;Site;skeletal;socioeconomics;Software Tools;Specimen;Spinal Fractures;spine bone structure;Spine surgery;Standardization;Structure;substantia spongiosa;success;System;Techniques;Technology;Therapeutic Intervention;tibia;Time;Translating;two-dimensional;United States Food and Drug Administration;Vertebral Bone;Vertebral column;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Comprehensive assessment of bone quality using clinical photon-counting detector CT

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Osteoarthritis;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Meniscus injuries are very common and frequently lead to early onset osteoarthritis, a leading cause of disability. This project will identify biomechanical and biological predictors of cartilage degeneration after meniscus injury and partial meniscectomy. Our findings will be utilized to improve care and outcomes for patients suffering from meniscus injuries.

PI_NAMEs: DEFRATE, LOUIS E.;GOODE, ADAM ;MCNULTY, AMY L (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: articular cartilage;Biochemical;Biological;Biological Factors;Biological Markers;biomechanical test;Biomechanics;Body Weight decreased;Cadaver;Caring;Cartilage;cartilage degradation;Cells;Characteristics;Clinical;clinical phenotype;Cluster Analysis;Computer Models;Data;Degenerative polyarthritis;demographics;Development;Dinoprostone;disability;early onset;Environment;Flow Cytometry;Future;Goals;Health;high risk;Image;imaging biomarker;Immune;improved;improved outcome;in vivo;Individual;Inflammation Mediators;Inflammatory;joint destruction;joint inflammation;joint injury;Joints;Knee;Knee Osteoarthritis;Lateral;Lead;Machine Learning;Macrophage;Magnetic Resonance Imaging;Maps;Matrix Metalloproteinases;Measures;Medial;Medial meniscus structure;meniscus injury;Meniscus structure of joint;Metabolic;Methods;Nonpharmacologic Therapy;Operative Surgical Procedures;Orthopedic Procedures;Participant;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmacologic Substance;Phenotype;Physical Rehabilitation;Physical therapy;Play;predictive modeling;prevent;primary outcome;Procedures;Public Health;radiological imaging;random forest;rehabilitation strategy;response;Risk;Roentgen Rays;Role;Serum;Speed;Subgroup;Synovial Fluid;targeted treatment;Techniques;Thick;three-dimensional modeling;Time;Tissues;treadmill;Validation;Walking

PROJECT_TITLE: Biomechanical and Biological Predictors of Cartilage Health Following Meniscus Injury

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE Oxycodone seeking increases after prolonged abstinence from drug self-administration. This proposal will combine novel chemoproteomic methods with a rat model to investigate projection-specific subcellular proteomes to advance our molecular understanding of mechanisms underlying oxycodone craving and relapse.

PI_NAMEs: LI, XUAN ANNA (contact);NEMES, PETER

PROGRAM_OFFICER_NAME: MCCLURE-BEGLEY, TRISTAN DAVID

PROJECT_TERMS: Abstinence;addiction;Amygdaloid structure;Analysis of Variance;analytical tool;Animal Model;Area;Bioinformatics;Brain;Cells;chemoproteomics;clinically relevant;Cluster Analysis;Complex;Corpus striatum structure;craving;Cues;Data;Data Analytics;Development;differential expression;Dorsal;drug abstinence;drug of abuse;drug relapse;Experimental Models;Exploratory/Developmental Grant;Exposure to;Female;Fluorescence;Fluorescence-Activated Cell Sorting;Genes;Genetic Transcription;Goals;Incubated;innovation;insight;interest;Intervention;Label;male;Mass Spectrum Analysis;Mediating;Methods;Modeling;Modernization;Molecular;Molecular Target;Mus;National Institute of Drug Abuse;neural;neuromechanism;neuronal cell body;neuronal circuitry;Neurons;Neuropeptides;Neurosciences;next generation sequencing;novel;Nucleus Accumbens;Ontology;Opioid;opioid epidemic;Oxycodone;oxycodone seeking;oxycodone self-administration;Pathway Analysis;Pharmaceutical Preparations;pharmacologic;postsynaptic;prescription opioid abuse;presynaptic;Presynaptic Terminals;Principal Component Analysis;prolonged abstinence;protein distribution;Proteins;Proteome;Proteomics;psychostimulant;Publishing;Rattus;Relapse;Resolution;Role;seal;Self Administration;Sorting;stem cells;Subcellular Fractions;Substance Use Disorder;Surveys;Synaptosomes;Techniques;Technology;Testing;Therapeutic;tool;transcriptomics;Translations;Viral;Work

PROJECT_TITLE: Subcellular Proteomics in Orbitostriatal Circuits in Incubation of Oxycodone Craving

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative This project will be the first to prioritize the daily experiences of bisexual and multigender-attracted (bi+) young adults and their partners when examining the proximal and prospective association between alcohol use and intimate partner violence (IPV) perpetration. In doing so, this study will enhance the scientific knowledge of alcohol use and IPV disparities among bi+ young adults and their partners – a population at high risk for heavy drinking and IPV – while addressing methodological limitations of existing alcohol-related IPV research that hinders the development of inclusive interventions. By identifying theoretically-informed daily experiences unique to bi+ young adults and their partners that potentiate (e.g., bi+ minority stress) or mitigate (e.g., partner support) alcohol-related IPV, results will provide critically-needed evidence of specific factors that should be targeted in alcohol-related IPV interventions for this priority population.

PI_NAMEs: BREM, MEAGAN JACQUELYN (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Adult;Age;Alcohol consumption;alcohol effect;alcohol related consequences;alcohol use disorder;Alcohols;Attenuated;Attitude;Behavior;binge drinking;Bisexual;Bisexuality;Characteristics;Conflict (Psychology);Couples;Data;design;Development;diaries;Discrimination;Disparity;drinking;effective intervention;experience;Exposure to;Foundations;Future;Gays;Gender;Gender Identity;Goals;harassment;Health;Heavy Drinking;Heterosexuals;high risk;Individual;Intervention;intimate partner violence;Knowledge;Lesbian;Link;Literature;Methodology;minority stress;minority stressor;neglect;Outcome;perceived discrimination;Persons;Population;pressure;Prevalence;Prevention;Process;prospective;psychologic;recruit;Reporting;Research;resilience;Risk;Role;sexual aggression;sexual identity;sexual minority;sexual minority stress;social stigma;Stigmatization;Stress;stressor;theories;Victimization;violence perpetration;young adult

PROJECT_TITLE: Daily Impact of Sexual Minority Stress on Alcohol-Related Intimate Partner Violence among Bisexual+ Young Adults: A Couples' Daily Diary Study

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Brain Disorders;Breastfeeding, Lactation and Breast Milk;Childhood Injury;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: NEUROLOGY

PHR: NARRATIVE In this proposal, we demonstrate the development of a therapeutic pipeline for preterm WMI in which pro- myelinating compounds are identified using a novel high-throughput screening method, followed by in vitro and in vivo validation and testing. Using our fabricated micropillar arrays, we propose to screen naturally occurring nutritional compounds found in breast milk to identify/confirm/validate compounds and pathways that promote myelination. We believe that our extensive experience with myelination and oligodendrocyte lineage cells and the strong preliminary data with the identification of N-acetylneuraminic acid (NANA) as a promyelinating compound, place us in a unique position to spearhead a novel approach for the development of therapeutics for WMI in premature infants.

PI_NAMEs: CHAN, JONAH R (contact);OSTREM, BRIDGET LAMONICA

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Acids;Affect;analog;Animal Model;bench to bedside;Brain Injuries;Breastfed infant;Bypass;Carbohydrates;Cell Lineage;cell type;Cells;Central Nervous System;Chronic;Coculture Techniques;cognitive disability;Cytoplasm;Data;Development;Dose;effective therapy;Esters;experience;experimental study;extracellular;global health;high throughput screening;Human;Human Milk;Hypoxia;Image;In Vitro;in vivo;Infant;insight;Knock-out;Libraries;Lysosomes;Membrane Proteins;Methodology;Methods;Modeling;Molecular Target;Motor disability;motor recovery;Mus;Myelin;myelination;N-Acetylneuraminic Acid;Neonatal;neonate;Neurological outcome;Neurons;novel;novel strategies;Nutritional;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Outcome Measure;Pathway interactions;Pinocytosis;Positioning Attribute;precursor cell;Premature Infant;Safety;scaffold;screening;Seizures;Sialic Acids;System;Testing;Therapeutic;therapeutic development;trafficking;translational potential;two-dimensional;uptake;Validation;Visualization;white matter injury

PROJECT_TITLE: Investigating the therapeutic potential of maternal breast milk components for preterm white matter injury

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Astrocyte border formation is a conserved feature of many CNS disorders but there are fundamental gaps in our understanding of the context specific functions of astrocytes borders across different CNS disorders because of the lack of robust bioassays to evaluate these cells. Here, we will advance a new bioassay to study the diverse states of astrocyte borders by using injectable biomaterials that controllably release small molecules and viral vectors to stimulate the formation and characterization of astrocytes borders. Successful completion of this project will lead to identification of conserved- and context-dependent functions of astrocyte borders and provide the foundations on which to explore therapeutic targeting of astrocyte border cells.

PI_NAMEs: O'SHEA, TIMOTHY MARK (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TITLE: Studying astrocyte borders using injectable biomaterials

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: RICHMOND

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE Primary care consolidation under health system ownership is increasing, but it is unclear how this will impact clinicians’ ability to achieve the National Academy of Medicine’s vision of High- Quality Primary Care and Whole Health. We will use multimedia elicitation surveys and focus group interviews to assess the impact of ownership on the delivery of high-quality care and to describe how contextual factors may help or hinder care. This information will inform national efforts and practice interventions to advance high-quality primary care and whole health.

PI_NAMEs: BROOKS, E. MARSHALL  (contact)

PROGRAM_OFFICER_NAME: EDEN, AIMEE

PROJECT_TITLE: Assessing the Impact of Health System Ownership on Fulfilling the Vision of High-Quality Primary Care and Whole Health

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Columbia University Department of Ophthalmology proposes to serve as the Coordinating Center for SIGHT STUDIES Evaluating the Effectiveness of Telehealth-Based Programs to Detect Glaucoma Among High-Risk Populations in Community Health Settings. The Coordinating Center will support Component A Awardees by providing scientific and logistical support to study the community-based interventions designed by Awardees. By serving as the administrative hub, the Coordinating Center will facilitate the development of a common, standardized protocol, coordinate the process to support communication, provide the website infrastructure for information exchange, and assist with the dissemination and translation of research findings.

PI_NAMEs: HARK, LISA A. (contact);SHUKLA, AAKRITI

PROGRAM_OFFICER_NAME: SANDERS, CELESTE

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 OHI (02)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative We will study the ubiquitin pathway in human cells and yeast, with an emphasis on identify roles for poorly understood ubiquitin ligases. This work will have a large emphasis on identifying substrates and determining the repercussions of not targeting those substrates.

PI_NAMEs: TOCZYSKI, DAVID PAUL (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Affinity;Alkylating Agents;Biological;Biological Process;CDK4 gene;Cell Cycle Progression;Cells;Chemicals;Complex;CRISPR library;CRISPR screen;CUL5 gene;Cytoskeleton;Dedications;DNA Damage;F-Box Proteins;FBXW7 gene;Genes;Genetic;Genetic Screening;Genetic Transcription;genome integrity;Human;Individual;inhibitor;Laboratories;Ligase;Mammalian Cell;Mass Spectrum Analysis;Metabolic Pathway;Methods;Mitochondria;Mitosis;mutant;Nuclear Export;Pathway interactions;Phenotype;Phosphorylation;Post-Translational Protein Processing;Post-Translational Regulation;protein folding;response;RNA Processing;Role;Signal Transduction;Specificity;Stress;System;Translations;Ubiquitin;ubiquitin ligase;Ubiquitination;Work;Yeasts

PROJECT_TITLE: Regulation by post-translation modifications in response to stress

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The interpretation of new variants, especially those revealed by genetic testing in the clinic, is difficult and hampers the use of genetic information to improve the diagnosis and treatment of disease. To empower variant interpretation, we propose the Center for Actionable Variant Analysis which would measure the effect of ~200,000 single nucleotide variants in ~32 of the most clinically important genes.

PI_NAMEs: FOWLER, DOUGLAS M;STARITA, LEA  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: actionable mutation;Benign;Biological Assay;Catalogs;Cell Survival;Cells;Clinic;Clinical;Clinical Data;Code;Consensus;Data;data analysis pipeline;data sharing;Diagnosis;Disease;Elements;empowerment;Ensure;Genes;genetic information;genetic testing;genetic variant;Genome;genome editing;Goals;Human Biology;improved;Individual;Life;Massive Parallel Sequencing;Measurement;Measures;Metadata;Methods;Modeling;multiplex assay;Nucleotides;Pathogenicity;Patient Care;Phenotype;Production;protein function;Proteins;Reagent;Reproducibility;Resolution;RNA Splicing;Single Nucleotide Polymorphism;Variant;variant of unknown significance;Work

PROJECT_TITLE: The Center for Actionable Variant Analysis; measuring variant function at scale


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Climate-Related Exposures and Conditions;Clinical Research;Contraception/Reproduction;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PUBLIC HEALTH RELEVANCE Weather extremes and air pollution impact birth outcomes, but the role of combinations of temperature, humidity, and air pollution together is not well understood. We propose to improve methods to estimate local temperature, humidity, and air pollution patterns at residential addresses, and investigate their acute association with spontaneous preterm birth in large datasets. Improving the ability to construct complex spatio- temporally varying environmental exposure estimates will inform future weather and air quality warning systems.

PI_NAMEs: JUST, ALLAN C. (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Acute;Address;administrative database;adverse pregnancy outcome;Air;air monitoring;Air Pollutants;Air Pollution;anthropogenesis;Assessment tool;Big Data;Birth;career;career development;Cessation of life;Chronic;Chronic Disease;Climate;climate change;climate-related health;cohort;Communication;Communities;Complex;cost estimate;Crossover Design;Data;data registry;Data Set;deprivation;Environmental Epidemiology;Environmental Exposure;Environmental Risk Factor;epidemiologic data;epidemiological model;Epidemiology;epidemiology study;Event;extreme temperature;extreme weather;fine particles;follow-up;Functional disorder;Future;future climate scenario;Gestational Age;Goals;greenhouse gases;Health;health application;Health Planning;Health Resources;health warning;Heat Waves;Home;Hospitals;Human;Humidity;improved;Individual;Infant;instrument;large datasets;Link;Literature;Machine Learning;Manuals;Measurement;Medical;Membrane;Methods;mobile application;Modeling;Modification;multidisciplinary;Neighborhoods;New York;novel;Outcome;Particulate Matter;Pattern;Perinatal Epidemiology;perinatal health;Persons;Phenotype;Philadelphia;Policies;Population;Population Characteristics;Positioning Attribute;predictive modeling;Predisposition;Pregnancy;Premature Birth;Premature Labor;Public Health;public health relevance;Race;Registries;remote sensing;Reproductive Health;reproductive outcome;Research;Resolution;response;Risk;Role;Rupture;Rural;Science;Series;sex;spatiotemporal;stressor;Subgroup;Surface;System;Technology;Temperature;temporal measurement;Testing;Time;Training;ultra high resolution;United States National Aeronautics and Space Administration;Variant;water vapor;Weather;Work

PROJECT_TITLE: Extreme temperature, humidity, air pollution and spontaneous preterm birth


NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE Our studies will use a model in which in utero exposure to maternal anti-Caspr2 antibody has sex-dependent effects on parvalbumin interneuron (PVI) development leading to altered sociability in male offspring. We will study the epigenetic changes that disrupt the normal maturation of PVIs and how that contribute to network imbalance in male, but not, female mice.

PI_NAMEs: BRIMBERG, LIOR  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adjuvant;Adult;Affect;Age;Antibodies;Apical;Apoptosis;Apoptotic;autism spectrum disorder;autistic children;Behavioral;behavioral phenotyping;Brain;calretinin;candidate identification;Cell Nucleus;Cells;Child;Cholecystokinin;Chromatin;Cleavage Under Targets and Release Using Nuclease;comparison control;Data;Dendrites;Development;disorder risk;Electrodes;Epigenetic Process;epigenetic regulation;Equilibrium;excitatory neuron;Exhibits;Exposure to;Extracellular Domain;Female;Functional disorder;Gene Expression Profile;Genetic;Genetic Transcription;hippocampal pyramidal neuron;Hippocampus;Human;human monoclonal antibodies;Immunization;Immunize;Immunoglobulin G;Immunohistochemistry;Implant;In Situ Nick-End Labeling;Interneuron function;Interneurons;Label;Location;male;Maternal antibody;Measures;Medial;Mediating;Mental disorders;migration;Modeling;Mothers;mouse model;Mus;Nervous System Disorder;neuronal cell body;Neurons;novel therapeutic intervention;Nucleic Acid Regulatory Sequences;offspring;Parvalbumins;Pathway interactions;Pattern;Phenotype;Physiologic pulse;Physiological;Play;postnatal;postsynaptic;Predisposition;Pregnancy;prenatal exposure;progenitor;Proliferating;Property;Proteins;Pyramidal Cells;receptor;Regulation;Regulator Genes;Research;response;risk variant;Role;sex;Sex Bias;Sex Differences;single nucleus RNA-sequencing;Slice;Somatostatin;stem cell proliferation;stem cells;Synapses;Techniques;Time;transcription factor;Transposase;Ventricular

PROJECT_TITLE: Sex dependent dysregulation of parvalbumin interneurons as a pathway to Autism Spectrum Disorder

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Comparative Effectiveness Research;Dementia;Hypertension;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Precision Medicine;Prevention

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative Hypertension is an important modifiable risk factor for Alzheimer's disease and related dementias (AD/ADRD), but the optimal blood pressure (BP) treatment target in older adults remains unclear, and intensive BP treatment may increase the risk of serious adverse events. By pooling individual data from multiple trials and employing advanced statistical methods, this proposal aims to identify subgroups that would benefit the most from intensive BP control for preventing cognitive decline and those at risk of serious adverse events. The findings will inform personalized BP targets and precision medicine strategies aimed at preventing AD/ADRD and promoting healthy aging.

PI_NAMEs: MA, YUAN  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adopted;Adverse event;adverse event risk;Affect;Age;aged;Alzheimer's disease related dementia;Alzheimer's disease risk;Blood Pressure;blood pressure control;Brain Ischemia;Cardiovascular system;cerebral hypoperfusion;Characteristics;Clinical;clinical practice;clinically relevant;Cognition;Cognitive;cognitive function;cognitive testing;Complex;cost effective;Data;Data Pooling;Dementia;dementia risk;Detection;Development;Dimensions;disorder risk;Equation;Evaluation;Event;fall injury;family burden;forest;Health;Health Status;healthy aging;Heterogeneity;Hypertension;Hypotension;Impaired cognition;improved;Individual;individualized medicine;insight;Knowledge;large scale data;late life;Life Expectancy;Machine Learning;machine learning algorithm;machine learning method;Methods;mild cognitive impairment;Modeling;modifiable risk;Nature;novel;older adult;Outcome;overtreatment;personalized approach;Population;precision medicine;prevent;Prevention;primary outcome;protective effect;Public Health;Randomized;randomized trial;Risk;Sample Size;secondary outcome;Serious Adverse Event;Societies;Specific qualifier value;Statistical Methods;Subgroup;Syncope;treatment effect;trial comparing;Variant;Work

PROJECT_TITLE: Precision blood pressure control, cognition and adverse events in older adults: detecting heterogeneity in treatment effects in randomized trialsusing machine-learning approaches

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative Alzheimer's Disease has recently been shown to be exacerbated by stress. This proposal seeks to establish new mechanisms that link Alzheimer's Disease pathology and physiologic stress response pathways.

PI_NAMEs: JUSTICE, NICHOLAS J (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: acute stress;Adrenal Cortex Hormones;affective disturbance;Age;Aggressive behavior;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Animals;antagonist;Anxiety;anxiety-related behavior;Behavior;behavior test;Behavioral;biological adaptation to stress;Blood Circulation;Body Size;Brain;Caregivers;Cell Nucleus;Cells;Chronic;Circulation;cognitive performance;comorbidity;Corticotropin;Corticotropin-Releasing Hormone;Deposition;design;Disease;Disease Progression;DNA cassette;Early Diagnosis;Early treatment;Electrophysiology (science);Endocrine;Enterobacteria phage P1 Cre recombinase;Etiology;experimental study;familial Alzheimer disease;FOS gene;Functional disorder;Glucocorticoids;Goals;Health;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Image;Immunofluorescence Immunologic;improved;in vivo;Knock-in;Knowledge;Link;Measures;Mediating;Mental Depression;Mental Health;Methods;Morphology;mouse model;Mouse Protein;Mus;mutant;Mutation;Nerve Degeneration;neural circuit;neuronal excitability;Neurons;neuropsychiatric symptom;neuropsychiatry;novel;Output;patch clamp;Pathogenesis;Pathway interactions;Patients;pharmacologic;Phenotype;Physiological;Pilot Projects;prevent;Production;Publishing;Quality of life;Regulation;Reporter;Rest;selective expression;Senile Plaques;Signal Transduction;Stains;Stress;Synapses;System;Testing;Toxic effect;Transgenes;Work

PROJECT_TITLE: Direct activation of CRF neurons by Abeta disrupts the stress response in Alzheimer's Disease

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE (verbatim, original text) We will develop a first-year-of-life, MRI-based predictive test for later autism spectrum disorder (ASD) diagnosis in a new cohort of infants (N=250) at high familial risk. This project has high public health relevance because of its promise for early, presymptomatic identification of infants who will develop ASD, making possible more efficient presymptomatic intervention studies of those infants at ultra-high risk.

PI_NAMEs: PIVEN, JOSEPH ;PRUETT, JOHN R (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: 2 year old;Affect;Age;Age Months;Appearance;Area;autism spectrum disorder;autism symptoms;autistic;Behavior;Behavioral;Biological Markers;Brain imaging;Categories;Characteristics;Child;Classification;Clinical;clinical predictors;clinical research site;Clinical Trials;clinically relevant;cohort;cost effective;Data;Detection;Development;Diagnosis;Diagnostic;Dimensions;Disease;Early Intervention;Education;Enrollment;Family;Funding;Future;Goals;Health Benefit;high risk;high risk infant;Impairment;Individual;infancy;Infant;Infrastructure;Intervention;Intervention Studies;joint attention;Language;Life;Magnetic Resonance Imaging;Measures;Methods;MRI Scans;neuroimaging;Outcome;Parents;pharmacologic;Population;predictive test;Predictive Value;presymptomatic testing;prospective;Public Health;public health relevance;Publishing;repetitive behavior;research clinical testing;Research Personnel;Rest;Risk;Sample Size;Sampling;Shapes;Siblings;Site;social;success;Surface;Testing;Text;Time;tool;Treatment outcome;Triage;Validation

PROJECT_TITLE: MRI Based Presymptomatic Prediction of ASD


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: NEW YORK

PHR: PROJECT NARRATIVE Dr. Christopher Morrison is a mid-career researcher who specializes in spatial epidemiologic studies of environmental strategies to prevent injuries. This K18 Career Enhancement Award will provide protected time to develop new content-area expertise in firearm injury prevention. Dr. Morrison will work with a team of new senior collaborators to conduct analyses of the National Longitudinal Study of Adolescent to Adult Health (Add Health), to identify modifiable predictors of firearm violence and develop interventions to prevent its occurrence.

PI_NAMEs: MORRISON, CHRISTOPHER NEIL (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Adolescence;Adolescent;Adolescent and Young Adult;Adult;aged;Attitude;Award;behavior influence;biobehavior;black men;career;career development;Cause of Death;Cessation of life;Characteristics;Cities;Code;Cohort Studies;Collaborations;community engagement;community violence;Complement;Complex;cost;Cox Proportional Hazards Models;Cues;Data;Dedications;design;Development Plans;Discipline;Economics;Ecosystem;Environment;Epidemiology;epidemiology study;Equation;experience;Exposure to;Feedback;Firearms;Goals;Growth;Gun injury;gun violence;Health;high risk;Home;Homicide;Hospitals;Household;Individual;Inequity;injured;Injury;injury prevention;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Intervention;intervention program;K-18 conjugate;Leadership;Learning;Life;Life Cycle Stages;Link;Longitudinal Studies;Measurement;Measures;Mental Health;Modeling;mortality;National Longitudinal Survey of Adolescent to Adult Health;neighborhood disadvantage;Neighborhoods;Outcome;Participant;Patient Self-Report;peer;Personal Satisfaction;Persons;physical conditioning;Policies;Polynomial Models;Populations at Risk;Positioning Attribute;prevent;Prevention;Prevention Research;preventive intervention;Process;professor;programs;Prospective, cohort study;protocol development;Protocols documentation;recruit;Research;Research Activity;Research Personnel;Research Priority;Resources;response;Risk;Safety;Sampling;Schools;Science;Scientist;secondary analysis;Shapes;Site;skills;social;social learning;Source;spatial epidemiology;Structure;Surveys;theories;Time;Training;United States;Universities;Victimization;Violence;violence perpetration;violence prevention;violence victimization;visiting scholar;Work

PROJECT_TITLE: Individuals' Longitudinal Risks for Firearm Violence Perpetration and Victimization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (51)]


NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Childhood Injury;Clinical Research;Emergency Care;Health Services;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Rehabilitation;Unintentional Childhood Injury

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Traumatic injury contributes to more deaths among children and adolescents in the United States than all other causes combined, and is the leading cause of preventable morbidity in pediatrics with over 100,000 children a year at risk of experiencing long-term impairments after severe injury. The goal of this proposal is to identify potentially modifiable post-injury clinical factors that contribute to poor long-term outcomes after pediatric trauma. Improving clinical management after an injury has occurred in order to optimize recovery may complement injury prevention efforts to reduce the overall burden of severe traumatic injury in children.

PI_NAMEs: KILLIEN, ELIZABETH Y (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Acute;Acute respiratory failure;Address;Admission activity;Adolescent;Affect;Award;Burn injury;career;Caring;Categories;Cause of Death;Cessation of life;Characteristics;Child;Child Health;Childhood;Childhood Injury;Clinical;Clinical Data;Clinical Management;cohort;Collaborations;Complement;Continuity of Patient Care;Critical Care;Critical Illness;Data;Database Management Systems;Deterioration;Development;Diagnosis;Dimensions;Ensure;experience;Exposure to;Family;Functional disorder;functional outcomes;functional status;Funding;Goals;Health;health assessment;health related quality of life;Health Status;Healthcare;Hospitalization;Hospitals;Housing;Hypoxemia;Impaired health;Impairment;improved;Injury;injury prevention;Intensive Care Units;Interdisciplinary Study;Intervention;long term recovery;Managed Care;Measures;Mechanical ventilation;Medical center;medical complication;Medicine;Mental Health;Mentorship;Methodology;Morbidity - disease rate;mortality;Multicenter Studies;National Institute of Child Health and Human Development;Organ;Outcome;Outcome Assessment;Patients;Pediatric Hospitals;pediatric trauma;Pediatrics;Post-Traumatic Stress Disorders;Prevention strategy;primary endpoint;Process;programs;Prospective Studies;psychosocial;Quality of life;Recovery;recruit;Research;Research Design;Research Personnel;Research Project Grants;Risk;Schools;Sedation procedure;Sepsis;Series;Service delivery model;severe injury;Severities;Shock;skill acquisition;Statistical Methods;Survivors;Time;Training;Trauma;Trauma patient;Traumatic injury;treatment strategy;United States;Universities;virtual;Washington;Work

PROJECT_TITLE: Clinical factors associated with long-term recovery following pediatric critical illness and injury

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PUBLIC HEALTH NARRATIVE: If successful, this project will provide evidence for the use of a peer navigation linkage to care model for integrated HIV care, HIV prevention care, and substance use disorder services for people living with HIV or at high risk for seroconversion, who also have a substance use disorder, as they are transitioning through jail. Development of an HIV-status neutral service delivery model for individuals with a range of substance use disorders, not only for opioids but also other illicit and licit substances, will benefit HIV prevention in Atlanta and other jurisdictions with similar drug use profiles.

PI_NAMEs: CONERLY HOLLIDAY, RHONDA C;SPAULDING, ANNE C (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Adherence;Administrator;Admission activity;Adoption;Adult;Affect;AIDS prevention;Alcohol consumption;antiretroviral therapy;Area;Behavioral;Black Populations;Black race;care outcomes;Caring;Case Management;cisgender;Client;clinical care;Cocaine;Communities;Consolidated Framework for Implementation Research;cost;cost estimate;County;Data;detention center;Development;Diagnosis;drug testing;Drug usage;Effectiveness of Interventions;effectiveness/implementation trial;efficacy trial;Epidemic;Evaluation;experience;Feedback;Frequencies;Funding;General Population;Goals;Health Services Accessibility;Heroin;heroin use;Heterosexuals;high risk;HIV;Hybrids;implementation barriers;implementation strategy;implementation study;implementation trial;Imprisonment;improved;Incidence;Individual;informant;information gathering;injection drug use;innovation;Intervention;intervention delivery;Intervention Studies;Interview;Jail;Justice;Legal;Legal system;Link;Maintenance;male;marijuana use;Measurement;Measures;Medical;medication compliance;metropolitan;Modeling;Motivation;Names;National Institute of Drug Abuse;Opioid;opioid use;Outcome;Outcome Measure;Outpatients;Participant;peer;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;pilot test;Population;Populations at Risk;pre-exposure prophylaxis;Prevention;primary outcome;Protocols documentation;Public Health;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Design;Risk;Risk Behaviors;Role;scale up;secondary outcome;Self Efficacy;seroconversion;Service delivery model;Services;Site;skills;social cognitive theory;Stimulant;substance use;Substance Use Disorder;Supervision;System;Testing;transgender;transgender women;transmission process;treatment as usual;treatment planning;trial design;Urine

PROJECT_TITLE: The Hub for Research in Atlanta on Addressing SUD to Promote HIV Elimination at Reentry (THRASHER)

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: HEIDELBERG

ORG_COUNTRY: GERMANY

ORG_FIPS: GM

ORG_NAME: EUROPEAN MOLECULAR BIOLOGY LABORATORY

PHR: To ensure effective communication between basic and clinical researchers, practicing clinicians and patients, there has to be a consistent well managed set of names for all human genes, which HGNC has provided since 1979. Having these names enables new discoveries, avoids confusion and prevents patient harm, by helping to ensure that everyone refers to a given gene using the same name.

PI_NAMEs: BIRNEY, EWAN  (contact);BRUFORD, ELSPETH ;FINN, ROBERT

PROGRAM_OFFICER_NAME: DI FRANCESCO, VALENTINA

PROJECT_TERMS: Area;authority;base;Biology;Canis familiaris;Cattle;Chickens;Clinical;clinical practice;clinically relevant;Code;Collaborations;Communication;Complex;Confusion;Consensus;Coupled;Cytochrome P450;Data;data exchange;data integration;Data Set;Databases;Drug Metabolic Detoxication;Ensure;Equus caballus;Family;Freezing;Funding;Future;Gene Duplication;Gene Family;gene product;Genes;Genetic Transcription;Genome;genomic data;Glucuronosyltransferase;Glutathione S-Transferase;Goals;Healthcare;Human;Human Genome;human genomics;interest;Language;Lead;Learning;Life;Machine Learning;Mammals;Manuals;member;model organism;Modeling;multiple data sources;Mus;Names;Nomenclature;novel;olfactory receptor;Open Reading Frames;Orthologous Gene;Pan Genus;parallelization;Patients;pharmacologic;Phenotype;precision medicine;prevent;Process;Proteins;prototype;Pseudogenes;Public Health;Publications;Publishing;Rattus;Research Personnel;Resources;RNA;Science;Source;Standardization;Study models;success;Syntenic Conservation;tool;Training;Untranslated RNA;Update;user-friendly;vertebrate genome;Vertebrates;web site;Work;Xenopus;Zebrafish

PROJECT_TITLE: The Nomenclature of Human and Vertebrate Genes


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative The olfactory system allows humans to evaluate the quality of food sources and to avoid harmful chemicals, thereby promoting overall health and quality of life. Relatively little is known about how higher order brain structures process olfactory information in mammals. The proposed experiments will further decipher the pattern of neural activity that underlies odor features in the olfactory cortex.

PI_NAMEs: DEWAN, ADAM KABIR (contact);VINCIS, ROBERTO

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Address;Affinity;Animals;Behavior;behavior measurement;Behavioral;behavioral study;Brain;Chemicals;Code;Data;Data Set;density;Detection;Development;Dimensions;Electrophysiology (science);Exhibits;experimental study;Exposure to;food quality;Future;Health;Human;improved;Individual;innovation;Knowledge;Learning;Left;Location;Mammals;Modeling;Mus;neural;neural correlate;neural network;neural patterning;neuromechanism;Neurons;Neurosciences;Noise;novel strategies;Odors;olfactory bulb;Olfactory Cortex;Olfactory Pathways;Operant Conditioning;Pattern;Perception;piriform cortex;Population;Process;Quality of life;receptor;Receptor Activation;response;Rodent;Signal Transduction;Silicon;Smell Perception;Source;spatiotemporal;Stimulus;Structure;System;Techniques;Testing

PROJECT_TITLE: An innovative approach to cracking odor coding in the piriform cortex

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Hematology;Rare Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project NARRATIVE Cellular properties can be altered by expression of a variant form of a protein. A particularly egregious situation arises from expression of a mutant transcription factor that exerts a dominant effect on the wild type form co-expressed in the same cell. The proposal is directed at establishing a new tool that selectively removes the mutant factor, leaving the wild type form intact and thus restoring a normal phenotype to the cell.

PI_NAMEs: BIEKER, JAMES J (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Address;Alleles;Anemia;Binding;Binding Sites;Biological;Categories;Cell Culture Techniques;cell type;Cells;Congenital dyserythropoietic anemia;Coupled;design;Development;Disease;DNA;DNA Binding;DNA Binding Domain;Dysplasia;erythroid Kruppel-like factor;Excision;experimental study;falls;Future;gene correction;Gene Expression Profile;Goals;Hematological Disease;Hematopoietic System;Heterozygote;high risk;In Vitro;in vitro testing;in vivo;innovation;innovative technologies;Kidney Diseases;leukemia;Medical;Methods;Missense Mutation;Morbidity - disease rate;mutant;Mutation;Patients;Pattern;Phenotype;Play;Property;protein expression;Proteins;Publishing;Role;Science;Series;small molecule;Solvents;Structure;success;technology development;Testing;tool;transcription factor;Urologic Diseases;Variant

PROJECT_TITLE: Development of selective degradation strategies towards mutant transcription factors

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: PATHOLOGY

PHR: NARRATIVE Microglia is a specialized cell type in brain that eliminates debris and dying neurons. Our recent data show that microglia cells, in a rare human early-onset dementia disease, known as Nasu-Hakola Disease, due to mutations in genes that control microglia activation and waste removal properties, have a specific dysregulated signature. We propose to investigate two crucial molecular pathways that could lead to these dysfunctional responses in vitro using microglia derived from pluripotent stem cells and in vivo in mouse models to understand how they impact microglia function. We believe that this research may advance our understanding of brain alterations in multiple neurodegenerative diseases.

PI_NAMEs: COLONNA, MARCO  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Adolescence;age related;Aging;Alzheimer's Disease;Apoptotic;Astrocytes;Astrocytosis;Attention;Attenuated;Automobile Driving;autosome;Binding;Biological Aging;Blood Vessels;Bone Cysts;Brain;Brain Pathology;Cause of Death;Cell Differentiation process;cell type;Cells;Central Nervous System;Cessation of life;cognitive function;Complex;cytokine;Data;Dementia;Dependence;Deterioration;disability;Disease;Disease Progression;early onset;embryo cell;Embryonic Development;Epidemiology;Excision;Exhibits;Family;Foundations;Fracture;Funding;Funding Mechanisms;gain of function;Gene Expression;Gene Expression Profile;Generations;Genes;Goals;Grant;Heterozygote;Human;human induced pluripotent stem cells;Impairment;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;Inherited;insight;Interleukin-10;Interleukin-6;Knock-in Mouse;Knock-out;Lead;Lipids;Lipoproteins;loss of function mutation;Macrophage;MAP Kinase Gene;Mediating;Mediator;Microglia;Molecular;Molecular Profiling;mouse model;Mus;mutant;Mutate;Mutation;myelination;Neurodegenerative Disorders;neuron loss;Neurons;Occipital lobe;Oligodendroglia;overexpression;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Phagocytosis;Phenotype;Phospholipids;Phosphorylation;Pluripotent Stem Cells;Production;programs;Property;Proteins;Reaction;receptor;Recurrence;repair function;Research;response;restraint;Risk;Role;RUNX1 gene;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Specimen;STAT3 gain of function;STAT3 gene;Stimulus;Symptoms;therapeutic target;tissue repair;Tissues;transcription factor;transcriptome;Transforming Growth Factor beta;transmission process;TREM2 gene;TYROBP gene;Tyrosine Phosphorylation;Variant;wasting;wound healing

PROJECT_TITLE: Elucidating the mechanisms by which microgliopathy causes early-onset dementia


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Biotechnology;Diabetes;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHYSICS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The proposed research is relevant to type 1 diabetes therapeutics, as the molecular phenotype of long-survival β cell could lead to the development of disease modifying interventions to improve the function of these cells. The goal of this project is highly relevant to the first mission of the HIRN (the consortium on beta cell death and survival).

PI_NAMEs: LIU, JING  (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Affect;Age;Alternative Splicing;Artificial Intelligence;Autoimmunity;Beta Cell;Binding;bioimaging;Bioinformatics;Body mass index;C-Peptide;Cell Death;cell dedifferentiation;Cell Nucleus;Cell Physiology;Cell Survival;Cells;Cellular Stress;Classification;Computer Vision Systems;computerized tools;Consensus;convolutional neural network;Cytoplasm;Data;deep learning;Development;Diabetes Mellitus;diabetes pathogenesis;Dimensions;Disease;Disparity;Evolution;Exhibits;Fluorescent in Situ Hybridization;functional improvement;Genetic Transcription;global health;Goals;Heterogeneity;Human;human imaging;human tissue;Hypoglycemia;illness length;Image;image registration;imaging informatics;Immune;Immune mediated destruction;Immune system;Impaired cognition;Individual;Insulin;Insulin-Dependent Diabetes Mellitus;Intervention;islet;Knowledge;Libraries;Life;Machine Learning;machine learning method;mathematical model;Mediating;Messenger RNA;Methods;MicroRNAs;Microvascular Dysfunction;Mission;Modeling;molecular imaging;molecular phenotype;mRNA Expression;Network-based;Noise;non-diabetic;Nuclear Envelope;Organ Donor;Paint;Pancreas;pancreas imaging;Pathologic;Persons;Phenotype;Process;protein expression;Proteins;Proteomics;Readiness;Research;Residual state;Resolution;restoration;RNA;Role;segmentation algorithm;sex;single molecule;Spatial Distribution;supervised learning;Testing;Therapeutic;Tissues;tool;transcriptome;transcriptomics;unsupervised learning;Work

PROJECT_TITLE: Image based Spatial Transcriptomics to Identify Beta Cell Phenotypes in Type 1 Diabetes


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Substance Misuse;Tobacco

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The findings from the proposed Supplement will enhance the activities of the parent award (Project SMART; R01DA054236) and a previous supplement by yielding research findings from the perspectives of social media influencers (SMIs) who would potentially collaborate on increasing the reach and impact of the intervention currently evaluated in the parent award. While the parent project focuses on effectiveness of tailoring of health messages to SGM youth, the supplement study will add crucial information to explore strategies to successfully partner with SMIs in future health communication interventions. Together, these findings would lead to the intervention being more likely to be integrated in the community, narrow the research-practice gap, ensure intervention approaches arising from this research are appropriate and sustainable for real-world settings, and ultimately reduce vaping among SGM youth.

PI_NAMEs: TAN, ANDY SL (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Age;Characteristics;cigarette smoking;Collaborations;Communities;Data Analyses;Education;Educational Intervention;Effectiveness;effectiveness evaluation;Ensure;expectation;experience;Future;Goals;Guidelines;Health;health communication;Health education;health organization;insight;interest;Intervention;Interview;Media Intervention;Modeling;Motivation;Outcome;parent project;Parents;Predisposition;prevent;Prevention;preventive intervention;Recommendation;Research;Research Personnel;response;Sexual and Gender Minorities;social;social factors;social media;Source;Suggestion;Surveys;Teenagers;theories;vaping;young adult;Youth

PROJECT_TITLE: Project SMART: Social Media Anti-vaping Messages to Reduce ENDS Use Among Sexual and Gender Minority Teens


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Hypertension;Machine Learning and Artificial Intelligence;Sleep Research

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Continuous monitoring of nocturnal blood pressure can help early diagnosis of developing cardiac conditions, reveal short term blood pressure variations, and also help the physician monitor differences in variations in response to medication for hypertensive patients. Moreover, the comfort and convenience of a wearable monitor would allow measurement in the natural context of daily life, including important nocturnal measurements, and reduce the burden of adherence on the user. The system will also provide feedback on quality of measurements to allow the users or care-givers to gauge reliability.

PI_NAMEs: JAFARI, ROOZBEH  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Adherence;Adult;advanced analytics;Affect;Age;Ambulatory Blood Pressure Monitoring;analytical method;Anti-Hypertensive Agents;arterial stiffness;Arteries;Awareness;Biometry;Blood flow;Blood Pressure;Blood Pressure Monitors;Blood Volume;Calibration;Cardiac;Cardiovascular Diseases;Cardiovascular system;Caring;Characteristics;Clinical;cohort;comorbidity;Data;Data Collection;Derivation procedure;design;Development;Devices;digital;Early Diagnosis;effectiveness validation;Environment;FDA approved;Feedback;Future;Healthcare;Heart Rate;Home;Hour;Human;Hypertension;hypertensive;insight;instrument;Investigation;Learning;Legal patent;Life;Link;Literature;Machine Learning;Marketing;Measurement;Measures;Mercury;Methods;Microfabrication;model development;Modeling;Monitor;monitoring device;Morphologic artifacts;Motion;motion sensor;Movement;multidisciplinary;Nature;Nocturnal Hypertension;novel;novel strategies;Organ;Outcome;Outcomes Research;Participant;Patient Monitoring;Patient risk;patient stratification;patient subsets;Patients;Pattern;Penetration;performance tests;Pharmaceutical Preparations;Physicians;Physiologic pulse;Physiology;Positioning Attribute;prognostic value;Proxy;Recording of previous events;Regimen;Research;response;Risk;Risk Factors;Science;sensor;sex;Signal Transduction;Site;Skin;Sleep;Sleep Deprivation;sleep position;Sphygmomanometers;Structure;Supination;Supine Position;System;Techniques;Technology;Time;Uncertainty;Validation;Variant;wearable device;wearable monitor;wearable sensor technology;willingness;Work;World Health Organization;Wrist;wrist worn device

PROJECT_TITLE: An Unobtrusive Continuous Cuff-less Blood Pressure Monitor for Nocturnal Hypertension

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Data Science;Dementia;Genetics;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Sleep Research

ORG_STATE: NY

PHR: Project Narrative The proposal aims to study two areas in the brain that are affected early in Alzheimer’s disease. We will use advanced gene expression techniques to understand how changes in these areas lead to memory loss and sleep problems. This will be combined with existing data on electrophysiology, behavior and sleep data.

PI_NAMEs: HUSSAINI, S. ABID  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Address;advanced analytics;Affect;Algorithms;Alzheimer's Disease;Amyloid beta-Protein;analysis pipeline;analytical tool;Architecture;Archives;Area;Arousal;Behavior;Benchmarking;Brain;Brain region;Characteristics;cloud based;cluster computing;Cognitive;complex data;computerized data processing;Computers;Custom;Data;data integration;Data Set;Database Management Systems;design;distributed archives;Early Diagnosis;Elasticity;Electrophysiology (science);entorhinal cortex;Evaluation;extracellular;FAIR principles;Functional disorder;Gene Expression;Genes;Goals;Hippocampus;Histology;Impaired cognition;Implant;improved;Knock-in Mouse;large datasets;Lead;locus ceruleus structure;Manuals;Memory;Memory impairment;Memory Loss;memory process;Mus;neural;Neuronal Dysfunction;Neurons;neurophysiology;novel strategies;open source;Parents;Pathology;Preparation;Process;Property;Publications;Publishing;remote location;Reproducibility;Research;Research Personnel;Resources;response;simulation;Sleep;Sleep Disorders;Sleep disturbances;Sorting;Standardization;System;tau aggregation;tau Proteins;Tauopathies;Techniques;Technology;Time;Tissues;tool;transcriptomic profiling;transcriptomics;Validation;Visualization software

PROJECT_TITLE: Electrophysiological Evaluation of Brain Regions Vulnerable to Alzheimers Disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Contact PD/PI: Pluciennik, Anna Public health relevance Genome instability is a hallmark a wide range of disease-states including cancer and neurologic conditions. Over two dozen neurodegenerative, musculoskeletal, and neurological disorders are caused by triplet repeat expansions, the mechanisms of which are not well understood. The studies proposed here will provide a deeper understanding of the crosstalk between DNA repair pathways and the impact of this crosstalk on repeat expansion and will also yield novel mechanistic insights into the function of enzymes that modulate repeat expansion, and will thus have wide-ranging biomedical implications. Project Narrative Page 7

PI_NAMEs: PLUCIENNIK, ANNA  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Attenuated;Biochemical;Cell Physiology;Chromosomal Rearrangement;cofactor;Deoxyribonucleases;Disease;DNA;DNA Damage;DNA Interstrand Cross-Link Repair;DNA Repair;DNA Repair Pathway;DNA Sequence;DNA Structure;Elements;environmental agent;Enzymes;Fragile X Syndrome;Friedreich Ataxia;Genetic;Genetic study;Genome;Genome Stability;Genomic Instability;Human Genome;Huntington Disease;insight;interest;Length;Malignant Neoplasms;Metabolism;Mismatch Repair;Molecular;Musculoskeletal Diseases;Mutation;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;novel;nuclease;Pathway interactions;prevent;Process;Production;protein protein interaction;Proteins;Proteomics;public health relevance;repair function;repaired;Replication Error;Role;Structure;Trinucleotide Repeats

PROJECT_TITLE: Crosstalk between DNA repair pathways in repeat instability


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition;Prevention

PHR: PROJECT NARRATIVE The nature of Inflammatory Bowel Disease (IBD) suggests genetically susceptible individuals are persistently colonized with mildly pathogenic microbial strains or lack colitoprotective strains. The majority of human gut microbiota strains remain stably colonized in our gastrointestinal tract from years to decades. Using microbial strain tracking methods and gnotobiotic mouse models of colitis, we will assess if colitogenic and colitoprotective human gut microbes stably or transiently colonize the human gut microbiota and explore the practical implications for this stability in the context of fecal microbiota transplantation for ulcerative colitis.

PI_NAMEs: FAITH, JEREMIAH JAMES (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Acute;Affect;Animal Model;Award;Bacteria;Characteristics;Chronic;clinical remission;Clinical Research;Clostridium difficile;Colitis;Collection;Communities;Crohn's disease;Disease;Disease remission;Donor person;Engraftment;Environmental Risk Factor;Escherichia coli;fecal microbiota;fecal transplantation;Future;Gastrointestinal tract structure;Genetic;genome sequencing;Germ-Free;Gnotobiotic;Goals;gut microbes;gut microbiome;gut microbiota;Human;human disease;IL2RA gene;Immune;Immune response;improved;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Intervention;Intestines;member;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial;microbiome;microbiome composition;microbiota;Minor;Mucosal Immune System;Mucous Membrane;murine colitis;Mus;Nature;novel;novel therapeutic intervention;novel therapeutics;Organism;pathogen;Pathogenicity;Patients;Penetrance;Persons;Pharmaceutical Preparations;Phenotype;Placebos;post-transplant;Predisposition;prevent;Prevention;Randomized, Controlled Trials;Recurrence;Relapse;relapse patients;relapse prediction;Role;Sampling;Severities;Severity of illness;System;T-Lymphocyte;Testing;Therapeutic;Time;Translations;Transplant Recipients;transplantation therapy;Ulcerative Colitis;virtual

PROJECT_TITLE: The Influence Of Gut Microbiota Stability In Inflammatory Bowel Disease

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention

ORG_CITY: MADISON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE FOR PARENT AWARD R01AI164690 Influenza virus engages cellular factors that are necessary for successful infection. Here we study the function of RNA:protein complexes formed during infection by both viral and host components. These studies will provide insight into the viral and host factors that regulate viral replication and host innate immune responses, and may ultimately identify new targets for therapeutic intervention.

PI_NAMEs: MEHLE, ANDREW  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Address;Affect;anti-influenza;Anti-viral Agents;Anti-viral Response;Binding;Binding Proteins;burden of illness;Cells;cellular targeting;Complex;Data;Detection;Development;direct application;disorder control;economic cost;Environment;Equilibrium;Event;experimental study;gene product;genetic association;Goals;Health Care Costs;Healthcare;Immune;immune activation;immunogenic;Impairment;Infection;Influenza;influenza infection;influenza outbreak;influenzavirus;Infrastructure;innate immune pathways;Innate Immune Response;insight;Integration Host Factors;Interferons;Invaded;Knowledge;Medical;Messenger RNA;Molecular;Morbidity - disease rate;mortality;new therapeutic target;novel;novel therapeutic intervention;Nucleic Acids;Nucleoproteins;Outcome;pandemic disease;parent project;pathogen;Pathway interactions;Pattern recognition receptor;Pharmacotherapy;prevent;Process;Production;Productivity;protein complex;Proteins;Public Health;public health intervention;Recurrence;Research;response;Ribosomes;RNA;RNA amplification;RNA-Protein Interaction;Role;seasonal influenza;sensor;Severities;Shapes;Strategic Planning;success;Testing;Therapeutic;Therapeutic Intervention;Translations;United States National Institutes of Health;universal influenza vaccine;Vaccination;Viral;Viral Physiology;Viral Proteins;viral RNA;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: RNA:protein interactions that dictate the success of influenza virus infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE To address public concern about high prescription drug prices and access to medications, legislators have adopted price ceiling control policies, such as monthly out-of-pocket caps for insulin, annual out-of-pocket caps for prescription drugs, and drug affordability boards with the power to set payment ceilings for high-cost prescription drugs. While price ceiling control policies are promising tools to improve access to and utilization of the targeted medications, they may have broader market effects. Using state-level insulin out-of-pocket caps as a case study, we examine whether price ceiling control policies lead to changes in the use of clinically preferred products to manage diabetes.

PI_NAMEs: DISTEFANO, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: KARACA, ZEYNAL

PROJECT_TITLE: Measuring the Impact of Price Ceiling Controls: A Case Study of Insulin Out-of-Pocket Caps

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE We engineered the first viable pre-clinical mouse model (termed Vac14ducky) of the pediatric VAC14-associated neurodegenerative disease, and using this new model, we have developed and completed preliminary analyses of a novel gene therapy (AAV9-hVAC14opt) for this disease. Following a single neonatal intrathecal injection of AAV9-hVAC14opt, the overall health and motor function of adult Vac14ducky mice was successfully rescued compared to vehicle-treated mice, with no detectable toxicities in control mice. Building on these exciting and promising results, the study proposed here will 1) define a minimal effective dose and 2) test post-symptomatic efficacy of AAV9-hVAC14opt in anticipation for IND application to the FDA.

PI_NAMEs: RIOS, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: 1 year old;adeno-associated virus 9 delivery;Adult;Affect;Age;Back;Brain;Cell Death;Cell Differentiation process;Cell Physiology;Cell Survival;Cells;Central Nervous System;Child;Childhood;Codon Nucleotides;Complex;Disease;Disease Progression;DNA Sequence Alteration;Dose;effective therapy;efficacy testing;Engineering;Evaluation;experimental study;Fibroblasts;Forelimb;Functional disorder;Gene Mutation;gene replacement therapy;gene therapy;Genes;Genetic;Goals;Hand Strength;Health;Human;human disease;improved;in vivo;Inherited;interest;Intrathecal Injections;Length;Life;Lipids;Medical;Missense Mutation;Modeling;Motor;motor function improvement;mouse model;Multiprotein Complexes;Mus;Mutant Strains Mice;Mutation;Neonatal;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;neuromuscular;novel;novel therapeutics;Osmotic Pressure;Parents;Patients;Phenotype;Play;Positioning Attribute;postnatal;pre-clinical;Pre-Clinical Model;pre-Investigational New Drug meeting;Preclinical Testing;prevent;progressive neurodegeneration;protein complex;Proteins;Recessive Genes;response;Role;Rotarod Performance Test;scaffold;Signal Transduction;Spinal Cord;Spinal Ganglia;Spinal Muscular Atrophy;Splice-Site Mutation;Striatonigral Degeneration;symptom treatment;Symptoms;Testing;Therapeutic;Tissues;tool;Toxic effect;Toxicology;Transcript;Treatment Efficacy;Vacuole;Weaning;Yeasts

PROJECT_TITLE: Pre-clinical testing of a novel gene therapy for pediatric neurodegenerative disease

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

PHR: Individuals with opioid use disorder are more likely to smoke cigarettes and have more difficulty quitting smoking than the general population, and they are also more likely to have problems with chronic pain. This research will examine whether switching to very low nicotine content cigarettes for four weeks can reduce symptoms of withdrawal, dependence, and pain-related urge to smoke in this population—factors that present significant barriers to quitting smoking. This research represents an important first step toward developing and testing an intervention to help people with opioid use disorder and chronic pain quit smoking and improve their health.

PI_NAMEs: MANNELLI, PAOLO ;SWEITZER, MAGGIE M (contact)

PROGRAM_OFFICER_NAME: HERRMANN, EVAN SULLIVAN

PROJECT_TERMS: Abstinence;Acetylcholine;Adherence;Aftercare;antinociception;Attenuated;Back Pain;Behavior;Behavioral;Biological Markers;Buprenorphine;buprenorphine treatment;Chronic;chronic pain;chronic pain management;chronic pain patient;Cigarette;cigarette smoke;cigarette smoking;clinical pain;common treatment;comorbidity;Complex;Counseling;craving;Cross-Priming;Data;Dependence;design;Development;Dose;Ecological momentary assessment;Exhibits;experience;Extinction;Frequencies;General Population;Goals;Health;Health Care Costs;Hour;Hyperalgesia;improved;Individual;insight;interest;Intervention;Interview;Laboratory Study;Learning;low nicotine content cigarette;Measures;medication for opioid use disorder;meetings;Motivation;Negative Reinforcements;Neurotransmitters;Nicotine;Nicotine Dependence;Nociceptors;non-cancer chronic pain;non-opioid analgesic;Opioid;Opioid agonist;opioid agonist therapy;Opioid Analgesics;opioid use;opioid use disorder;opioid withdrawal;osteoarthritis pain;Outcome;Pain;Pain intensity;Pain interference;pain outcome;pain relief;pain sensitivity;Participant;Pathway interactions;Patient Self-Report;Patients;Persons;Phase;Population;Positive Reinforcements;prescription opioid;Price;Productivity;Psychological reinforcement;Randomized;Reaction;reduce symptoms;Reporting;Research;Risk;Risk Factors;Role;Self Efficacy;Smoke;Smoking;smoking abstinence;Smoking Behavior;smoking cessation;Smoking Cessation Intervention;Stimulus;substance use;success;System;Testing;therapy development;Time;Tobacco;Tobacco smoking behavior;Tobacco use;tool;Visit;Vulnerable Populations;willingness;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Targeting Reinforcement Mechanisms for Smoking Cessation Using Very Low Nicotine Content Cigarettes in Individuals with Opioid Use Disorder and Chronic Pain

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Microbiome;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Impaired oral and systemic health associated with adverse childhood experiences (ACEs) disproportionately impacts children, especially those who belong to racial or ethnic minority groups. A strong epidemiological association has been identified between ACEs and dental caries, but the limited understanding of the biological factors underlying ACE-associated dental caries remains an essential knowledge gap. Given the substantiated role of the brain–gut–microbiome axis in ACE-associated systemic diseases and the induction of stress response molecules in saliva, the brain–oral microbiome (BOM) axis may serve as a plausible mechanism through which ACE-associated dental caries impact the oral microbiome, and studying the BOM axis may generate knowledge to inform clinical management and future policies to mitigate caries disparity in children with early-life adversities.

PI_NAMEs: TRAN, NINI CHAICHANASAKUL (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Adult;adverse childhood events;Affect;aged;Asthma;Behavioral;Biochemical;Biological;biological adaptation to stress;Biological Factors;Biological Markers;biological systems;Biometry;biopsychosocial;Brain;Caries prevention;Child;childhood adversity;Clinical;Clinical Management;Clinical Research;cohort;Cohort Studies;Complex;cost;cross immunity;demineralization;Dental;Dental caries;Dental Enamel;Development;Diet;Disease;disease disparity;Disparity;Dose;dysbiosis;early life adversity;Economic Burden;Enrollment;Environment;Epidemiology;ethnic minority population;Etiology;experience;Future;Goals;gut microbiome;Health;Healthcare;high risk;high risk population;host microbiome;Immune;Immune response;Immune system;Immunity;Immunologic Markers;Immunologics;Impairment;imprint;infection risk;innovation;Integration Host Factors;Intervention;Investigation;Knowledge;Life;Link;Los Angeles;Medical;Metagenomics;microbial;microbial composition;microbiome composition;Modeling;Morbidity - disease rate;mortality;Mouth Diseases;multi-ethnic;Neurosecretory Systems;Obesity;Oral;Oral health;oral microbiome;Pathologic;Pathway interactions;Personal Satisfaction;Play;Policies;poor health outcome;Population;Prevalence;Preventive care;Preventive dental care;Process;Psychological Factors;psychosocial;Public Health;Publishing;racial minority;recruit;Reporting;Research Design;Resolution;Resources;response;response biomarker;Role;Saliva;saliva sample;Salivary;sex;Sleep disturbances;social factors;sociodemographics;Stress;Stressful Event;stressor;study population;Systemic disease;Testing;Trauma;traumatic event;underserved community;United States;Urban Community;Work

PROJECT_TITLE: The Role of Brain-Oral-Microbiome Axis in Adverse Childhood Experiences-associated Dental Caries in Children

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]