NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Networking and Information Technology R&D (NITRD);Nutrition;Patient Safety;Physical Activity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Narrative We use Electronic Health Records (EHR) data of over 527,000 patients with incident diabetes who were diagnosed and treated in the Southern California Kaiser Permanente (KPSC) health care system from 1993- 2020 to update the United Kingdom’s Prospective Diabetes Study (UKPDS) risk equations. KPSC’s diverse and vast membership further allows us to estimate UKPDS risk equations separately for major racial/ethnic groups. We will also explore the impact of health behaviors on diabetes trajectories including exercise and referrals to diabetes and weight management education classes.

PI_NAMEs: NAU, CLAUDIA LEONIE (contact)

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: African American;African American population;African Caribbean;Amputation;Asian;Asian Americans;Asian Indian;Behavior Therapy;Behavioral;Biological;Black race;Blindness;British;California;Cessation of life;Characteristics;Chronic Disease;clinical decision support;cohort;Complications of Diabetes Mellitus;Congestive Heart Failure;cost;Cost Effectiveness Analysis;Data;Data Set;diabetes education;diabetes management;Diabetes Mellitus;diabetes risk;Diabetic Retinopathy;diabetic ulcer;Diagnosis;diet and exercise;Disease Progression;Disparity;East Asian;Education;Electronic Health Record;Equation;Equity;Ethnic Origin;Ethnic Population;Event;Exercise;experience;follow-up;Goals;Health;Health behavior;health equity;Healthcare Systems;Hispanic;Hispanic Americans;improved;Incidence;Individual;Information Systems;Integrated Health Care Systems;Kidney Failure;Left;lifetime risk;member;Methodology;Modeling;models and simulation;mortality;Myocardial Infarction;Myocardial Ischemia;Needs Assessment;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Outcome;outcome prediction;Outcome Study;Patient Education;Patient Self-Report;Patients;Persons;Physical activity;Play;Population;Population Group;Population Heterogeneity;Preparation;Prevalence;prospective;Race;racial difference;racial population;Reporting;Risk;Risk Estimate;risk stratification;Role;Sampling;Sampling Studies;secondary analysis;semiparametric;Services;social;sociodemographics;Stroke;Subgroup;Time;Ulcer;United Kingdom;United States;Update;Validation;Weight maintenance regimen

PROJECT_TITLE: New Risk Models for Diabetes Complications Using Electronic Health Records

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Vaccine Related

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: OYAGEN, INC.

ORG_STATE: NY

PHR: There is an urgent need for the development and commercialization of highly effective treatments for COVID-19. Currently there are only limited FDA-approved therapeutics to combat the SARS- CoV-2 (CoV-2) virus that has caused the COVID-19 global pandemic, killing more than 6.4 million people worldwide to date. OyaGen has discovered that sangivamycin is a highly potent antiviral for CoV-2. Sangivamycin was proven safe when evaluated in human cancer clinical trials performed in the 1960’s. It however was ineffective against cancer and abandoned. In this Phase I SBIR application, preclinical studies are proposed in response to FDA guidance that will be IND- enabling and a prerequisite to Phase I clinical trial safety and pharmacokinetics evaluation in healthy volunteers. The development of sangivamycin as a therapeutic for infected patients is a medical countermeasure for immunocompromised people who may not benefit from vaccine immunization as well as a stop gap therapeutic for new strains of CoV for which current vaccines may be less effective. Importantly, our data support that sangivamycin has the potential to enhance the efficacy of other therapeutics as a combination therapy option in the future.

PI_NAMEs: BENNETT, RYAN P (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Acute;Adenosine;Agreement;Animal Model;animal safety;Animals;anti-cancer therapeutic;Anti-viral Agents;anti-viral efficacy;attributable mortality;Body Weight decreased;cancer clinical trial;Canis familiaris;Caymans;Cells;chemical synthesis;Chemicals;Chickens;China;Clinic;Clinical;Clinical Trials;combat;Combined Modality Therapy;commercialization;comparison control;Control Animal;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 therapeutics;COVID-19 treatment;Data;design;Development;Dose;Drops;Drug Kinetics;Drug resistance;Ducks;effective therapy;Enzymes;Evaluation;Family suidae;FDA approved;Felis catus;Ferrets;fighting;Formulation;Funding;Future;Goals;Guide RNA;Half-Life;Hamsters;healthy volunteer;Hour;Human;human subject;Immunization;Immunocompromised Host;In Vitro;in vivo;Individual;Infection;Inflammatory Response;Intravenous;intravenous injection;Label;Legal patent;Licensing;Lower respiratory tract structure;Lung;Macaca;Malignant Neoplasms;Maximum Tolerated Dose;medical countermeasure;meetings;Mesocricetus auratus;Modeling;Mus;Nasal cavity;National Institute of Allergy and Infectious Disease;nucleoside analog;Outcome;Ownership;pandemic disease;Patients;Persons;Pharmacologic Substance;Phase;Phase I Clinical Trials;Phosphorylation;preclinical development;preclinical study;programs;Published Comment;Pulmonary Inflammation;Recommendation;Recovery;Regimen;remdesivir;Research;research facility;resistant strain;response;RNA;Safety;sangivamycin;SARS coronavirus;SARS-CoV-2 antiviral;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 variant;Serum;Severe Acute Respiratory Syndrome;Small Business Innovation Research Grant;small molecule;Technology;Testing;Texas;Therapeutic;therapeutic candidate;timeline;Tissues;Tritium;Upper respiratory tract;Vaccines;Variant;Viral;Viral Load result;viral RNA;Viremia;World Health Organization

PROJECT_TITLE: IND-Enabling Development of a Small Molecule COVID Therapeutic

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Three plasma phosphorylated tau epitopes (p-tau231, p-tau181, p-tau217) have recently emerged as important tools to study Alzheimer’s disease (AD) pathophysiology. However, the difference in performance between these epitopes to identify the AD continuum is poorly understood, making it difficult for the field to choose the plasma p-tau epitope or combination of epitopes that will advance for widespread use in clinical trials and practice. We will measure the p-tau231, p-tau181, p-tau217 assays in longitudinally collected plasma samples, with associated positron emission tomography tau and amyloid-beta, from individuals across the AD spectrum to elucidate the performance of each p-tau epitope to use in research and clinical settings.

PI_NAMEs: PASCOAL, THARICK  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta deposition;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Amyloid beta-Protein;beta amyloid pathology;Biological Assay;Biological Markers;Blood;Blood Tests;Brain;Bypass;Cerebrospinal Fluid;Characteristics;Classification;Clinical;clinical practice;Clinical Trials;Cognitive;cohort;Collection;Data;Dementia;design;Deterioration;Diagnosis;Diagnostic;Disease;Disease Progression;drug candidate;drug development;Early identification;Enrollment;Epitopes;follow-up;Functional disorder;Future;Goals;Head;head-to-head comparison;Image;Individual;large scale data;Light;Measurement;Measures;mild cognitive impairment;Monitor;Neurobehavioral Manifestations;neurofilament;novel;Outcome;Participant;Pathology;Patient Care;Patients;Performance;Plasma;Population;Positron-Emission Tomography;programs;Rapid screening;recruit;Research;Research Design;research study;Sampling;Scanning;screening;Sensitivity and Specificity;Sum;tau aggregation;tau Proteins;tau-1;Technology;Testing;Threonine;tool;Visit

PROJECT_TITLE: Head-to-head comparisons of high-performance plasma phospho-tau epitopes for the detection of Alzheimer's disease

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PI_NAMEs: BAUMAN, MELISSA DAWN (contact)

PROJECT_TERMS: Acute;Address;Age Months;Animal Model;Animals;Autopsy;Bacterial Infections;Behavior;Behavioral;behavioral outcome;behavioral phenotyping;Biological Assay;Biological Markers;Biological Models;Biopsy;Birth;Blood specimen;Brain;brain tissue;cell type;Child;Clinical;Cognitive;cognitive control;cohort;Collaborations;computer framework;Conceptions;cytokine;Data;Decidua Basalis;Development;Diagnosis;Disease;Environment;epidemiology study;Etiology;Evaluation;Exhibits;experience;Exposure to;Female;fetal;fetal blood;Fetal Tissues;Gene Expression;Goals;gray matter;Growth;Heterogeneity;Human;human disease;Immune;immune activation;immune function;Immune system;Impairment;indexing;Infection;Inflammatory;inflammatory marker;insight;Knowledge;Lead;Link;Macaca mulatta;male;maternal immune system;Measurement;Measures;Mental disorders;Modeling;Monkeys;Motivation;Mus;Neuroanatomy;neurobehavioral;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;Neuroimmunomodulation;nonhuman primate;offspring;Outcome;Outcome Measure;patient population;Peripheral;Phenotype;Physiology;Placenta;Population;postnatal;postnatal period;Pre-Clinical Model;Predictive Factor;Predisposition;Pregnancy;prenatal;prepuberty;Primates;resilience;response;Risk;Risk Factors;Rodent;Sampling;Schizophrenia;sex;Sex Differences;social;Social Behavior;Structure;success;Systems Development;Time;timeline;tissue archive;Tissue Sample;Tissues;Virus Diseases;Woman;women's treatment;young adult

PROJECT_TITLE: Project 3: Neurodevelopment in an NHP MIA model


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LITTLE ROCK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE  Intracellular membrane trafficking that mediates the delivery of secretory and endocytic cargo proteins and lipids is critical for a range of cellular functions, including protein secretion, post-translational modifications, signaling, cell polarization, and cell maintenance. Defects in membrane trafficking can underlie or exacerbate many human diseases, including cancer, diabetes, Alzheimer’s disease, cystic fibrosis, Hermansky-Pudlak syndrome, and congenital disorders of glycosylation. In this project, we will uncover the molecular basis for protein-protein interactions and regulations of key components of the Golgi trafficking machinery and create a novel cellular model to study congenital disorders of glycosylation.

PI_NAMEs: LUPASHIN, VLADIMIR V (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Affect;Affinity Chromatography;Alzheimer's Disease;autosome;base;Binding;Biochemical;Biotinylation;bone;Categories;Cell Line;Cell Maintenance;Cell model;Cell Physiology;Cells;Congenital disorders of glycosylation;Conserved Sequence;Cystic Fibrosis;Defect;Development;Diabetes Mellitus;Disease;Docking;Environment;Enzymes;Fibroblasts;flexibility;Fluorescence Microscopy;glycosylation;Golgi Apparatus;golgin;Hermanski-Pudlak Syndrome;Human;human disease;human induced pluripotent stem cells;Impairment;In Vitro;in vivo;induced pluripotent stem cell;Intracellular Membranes;Kinetics;Label;Leg;Lipids;Liver;Malignant Neoplasms;Medial;Mediating;Membrane;Membrane Fusion;Microcephaly;Microscopic;Microscopy;Modeling;Molecular;Mutation;Nature;Neurologic;Neurons;novel;Occupations;Pathway interactions;Patients;Phenotype;Physiological;polarized cell;Population;Post-Translational Protein Processing;Process;protein protein interaction;Protein Secretion;Protein Sortings;Proteins;Proteomics;receptor;Recycling;Regulation;Set protein;Signal Transduction;skeletal;SNAP receptor;stem cells;success;Symptoms;System;Testing;therapy development;tissue/cell culture;Tissues;trafficking;Treatment Protocols;ultra high resolution;Vesicle;vesicle transport

PROJECT_TITLE: Characterization of mammalian COG complex-interacting Golgi trafficking machinery

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CINCINNATI

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Heart failure is the no. 1 killer in United States, with rates expected to rise by 25% by 2030. However, our understanding of the molecular mechanism leading to cardiac hypertrophy and heart failure is still limited. This proposal aims at exploring the mechanism as well as therapeutic targets for cardiovascular disease.

PI_NAMEs: GAO, CHEN  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: 3' Untranslated Regions;Alternative Splicing;Area;Binding;Biology;Cardiac;Cardiac Myocytes;Cardiology;Cardiovascular Diseases;career;career development;Cell Nucleus;coronary fibrosis;crosslinking and immunoprecipitation sequencing;Development Plans;Disease;Disease Progression;Event;experimental study;fetal;Foundations;Functional disorder;Future;Gene Delivery;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;Goals;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;In Vitro;in vivo;Inflammatory;insight;Ischemia;Knowledge;Mediating;Messenger RNA;MicroRNAs;Molecular;Molecular Analysis;mouse model;mRNA Decay;Mus;Muscle;Muscle Cells;Myocardial Infarction;novel;Nuclear;Organ;Outcome;Pathogenesis;Pathologic;Pathology;Phase;Physiology;Play;post-doctoral training;Post-Transcriptional Regulation;posttranscriptional;pressure;Process;Protein Isoforms;Proteins;Regulation;Reperfusion Injury;Reporting;Repression;Research;Research Personnel;response;ribosome profiling;Ribosomes;RNA;RNA Decay;RNA metabolism;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;skills;Stress;Supervision;Testing;Tetanus Helper Peptide;therapeutic target;transcriptome;transcriptomic profiling;Transgenic Mice;Translations;United States;Variant

PROJECT_TITLE: Novel Mechanism of RBFox1 Mediated RNA Metabolism in Heart Failure

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Women's Health Research

PI_NAMEs: GESCHWIND, DANIEL H (contact)

PROJECT_TERMS: Address;Affect;Animal Model;Archives;autism spectrum disorder;Behavior;Behavioral;behavioral outcome;Biological;biomarker identification;Blood;Brain;brain cell;Brain region;cell type;Cells;cohort;Collaborations;Corpus striatum structure;cytokine;Data;data integration;design;Development;Disease susceptibility;Dose;Environmental Risk Factor;epidemiology study;Female;fetal;FOXP3 gene;Funding;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic study;Genetic Transcription;Human;human disease;Image;Immune;immune activation;Immune response;Immunologic Factors;immunoreactivity;Individual;insight;Interneurons;Intervention;Link;male;Male Adolescents;Measures;Mediating;Mental disorders;Methylation;Modeling;Molecular;Mothers;mouse model;Multivariate Analysis;Mus;neurobehavioral;Neurobiology;Neurodevelopmental Disorder;Neuroimmune;Neuroimmunomodulation;Neurons;neuropathology;neuropsychiatric disorder;nonhuman primate;novel;Nuclear;offspring;Outcome;Pathway Analysis;Pathway interactions;Phenotype;Placentation;Poly I-C;Population;postnatal;Predisposition;Prefrontal Cortex;Pregnancy;prepuberty;prevent;regional difference;Regulator Genes;Regulatory T-Lymphocyte;repetitive behavior;resilience;response;Risk;Risk Factors;Sampling;Schizophrenia;sex;Sex Differences;Spliced Genes;Structure;success;Synapses;System;Time;Tissues;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;whole genome;Work

PROJECT_TITLE: Project 4: Refining transcriptional networks in MIA


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Social Determinants of Health;Substance Misuse;Violence Research

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Up to 68% of child welfare cases involve a caregiver with an alcohol and/or other substance use disorder (AOSUD), which is significant given that in 2020 there were 3.9 million child welfare referrals involving 7.1 million children! Child welfare professionals lack knowledge of AOSUDs and their evidence-based treatments and many caregivers’ AOSUDs go unidentified and untreated, which puts children at greater risk for maltreatment and out-of-home placements. The proposed training program seeks funding to enhance Virginia Commonwealth University’s (VCU) federally-supported Title IV-E child welfare professional training program with specialized training on AOSUDs integrated with ongoing clinical/peer supervision and tele-education, creating an innovative training model that can be adopted across the country’s network of almost 150 Title IV-E programs to improve child welfare outcomes nationally.

PI_NAMEs: CHARTIER, KAREN G. (contact);GOMEZ, REBECCA JEAN

PROGRAM_OFFICER_NAME: DUCHARME, LORI

PROJECT_TERMS: addiction;Address;Adopted;alcohol abuse therapy;alcohol use disorder;Alcohols;Area;behavior change;Caregivers;Child;Child Abuse and Neglect;Child Welfare;Clinical;Communities;Competence;Complex;Country;Development;Education;education research;Educational Models;Educational workshop;effective intervention;effective therapy;Evidence based intervention;Evidence based program;Evidence based treatment;Family;Feedback;Fellowship Program;foster care;Funding;Goals;Health Professional;high risk;Home;improved;Individual;innovation;Intervention;Interview;Knowledge;Link;maltreatment;Medical;medication-assisted treatment;Methods;Modeling;multidisciplinary;opioid epidemic;Outcome;outreach program;Patients;peer;Prevention;Professional Practice;programs;Provider;Psychiatry;Public Health;Qualifying;Qualitative Methods;recruit;Resources;response;Risk;screening;Services;skills;social stigma;Social Work;Social Workers;Specialist;standardize measure;Stigmatization;Substance abuse problem;substance use;Substance Use Disorder;Supervision;System;Time;Training;Training and Education;Training Programs;underserved community;United States Substance Abuse and Mental Health Services Administration;Universities;Virginia

PROJECT_TITLE: Equipping social workers on the front line: The child welfare and addiction specialist fellowship program

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Rehabilitation;Stroke

ORG_CITY: CHAPEL HILL

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Standardized and psychometrically sound methods for assessing speech impairments after left hemisphere stroke will improve transparency, consistency, and accuracy of clinical management. The identification of clinically valid performance profiles will improve precision of diagnosis and treatment.

PI_NAMEs: HALEY, KATARINA L (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TITLE: Speech Profiles and Cue Responsiveness After Left Hemisphere Stroke

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Schizophrenia;Serious Mental Illness;Women's Health Research

PI_NAMEs: CARTER, CAMERON S. (contact)

PROJECT_TERMS: Address;Adolescence;Age;Age Months;anatomic imaging;Anatomy;Animals;Anterior;Behavior;Behavioral;Behavioral Assay;behavioral study;Biological Markers;Brain;brain circuitry;cingulate cortex;Clinical;clinically relevant;cognitive control;Computer Models;Corpus striatum structure;COVID-19 pandemic;Data;Data Analyses;Detection;Development;Diffusion Magnetic Resonance Imaging;Dopamine;early adolescence;Epidemiology;epidemiology study;extracellular;Female;frontal lobe;Functional disorder;Functional Magnetic Resonance Imaging;Funding;gray matter;Heterogeneity;Human;Image;imaging study;Immune;immune activation;Immune response;immunoreactivity;Incentives;Individual;insight;Link;Magnetic Resonance Imaging;male;maternal immune system;Measurement;Measures;Mental disorders;Midbrain structure;Modeling;Molecular;Mothers;Motivation;mouse model;Mus;neural;neural circuit;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;Neuroimmune;Neuroimmunomodulation;neuroinflammation;neuromelanin;nonhuman primate;novel;offspring;Outcome;Patients;Phenotype;Pilot Projects;postnatal;postnatal period;Pregnancy;Proxy;Psychopathology;recruit;resilience;Resolution;Risk;Role;Sampling;Scanning;Schizophrenia;Self-Injurious Behavior;serial imaging;sex;Sex Differences;social;Symptoms;synaptic function;System;Testing;Thick;Time;Tissues;Water;women's outcomes;young adult

PROJECT_TITLE: Project 5: Systems and circuits in MIA and schizophrenia


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Immunotherapy;Mental Health;Palliative Care;Patient Safety

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Treatment with immune checkpoint inhibitors is promising for many types of cancer. Self-management of symptoms with timely reports to the healthcare providers is necessary to prevent immune-related adverse events. A highly scalable intervention sequence consisting of an automated telephone intervention with need- based addition of a counseling intervention for survivors with persisting psychological distress will be tested in this project.

PI_NAMEs: BADGER, TERRY A (contact);SIKORSKII, ALLA

PROGRAM_OFFICER_NAME: MITCHELL, SANDRA A

PROJECT_TERMS: active control;active control group;adaptive intervention;Address;Affect;Anxiety;Cancer Survivor;cancer therapy;cancer type;Characteristics;Cognitive;Common Terminology Criteria for Adverse Events;Communication;Counseling;Data;design;Diagnosis;Dose;Electronic Health Record;Electronic Mail;Emergency department visit;Emotional;end of life;evidence base;Exanthema;experience;Fatigue;Guidelines;handbook;Health Insurance Portability and Accountability Act;Health Personnel;health service use;Health Services;Hematologic Neoplasms;Hispanic;Hospitalization;Immune checkpoint inhibitor;immune-related adverse events;improved;indexing;Individual;Interruption;Intervention;Interview;Lead;Link;Malignant Neoplasms;Mediating;Mental Depression;Monitor;Oral;Organ;Pain;Participant;Patient Outcomes Assessments;Patient Selection;Population;post intervention;prevent;primary outcome;Printing;psychological distress;Randomized;Reporting;Resources;response;Science;secondary outcome;Self Efficacy;Self Management;Sentinel;Sequential Multiple Assignment Randomized Trial;Severities;sleep difficulty;Social support;Solid;Spanish;Steroids;success;Supportive care;Survivors;symptom management;symptom self management;symptomatic improvement;Symptoms;Systemic Therapy;Technology;Telephone;Testing;Time;treatment guidelines;Treatment-Related Cancer;trial design;Voice;Work

PROJECT_TITLE: Adaptive Symptom Self-Management to Reduce Psychological Distress and Improve Symptom Management for Survivors on Immune Checkpoint Inhibitors

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: OMAHA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Ovarian cancer is the deadliest gynecologic malignancy, accounting for ~25,000 cases and ~15,000 deaths annually in the United States. This project investigates RHNO1, a newly discovered oncoprotein and potential therapeutic target in this disease. Our studies will investigate the role of RHNO1 in ovarian cancer and identify the first small molecule inhibitors that inhibit the function of this protein.

PI_NAMEs: KARPF, ADAM R. (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Ablation;Accounting;Address;advanced disease;Apoptosis;Ascites;Binding;Biochemical Pathway;biological adaptation to stress;Biological Assay;Biological Markers;cancer cell;Cancer cell line;Cancer Patient;cancer therapy;Carboplatin;Cell Line;Cell Survival;Cells;Cessation of life;CHEK1 gene;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;counterscreen;Development;Diagnosis;Disease;Disease Resistance;DNA biosynthesis;DNA Damage;DNA Repair;Drug Design;Drug Targeting;Epithelial Cells;Exhibits;Fluorescence Polarization;Future;Goals;Greater sac of peritoneum;Growth;high standard;high throughput screening;homologous recombination;Human;Hus1 protein;Image;Immunohistochemistry;Implant;in vivo;inhibitor;innovation;intraperitoneal;Investigation;Kinetics;Knock-out;knockout gene;Luciferases;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Measures;Mediating;Modeling;Morbidity - disease rate;mortality;Mus;Mutation;Neoplasm Metastasis;new therapeutic target;Normal tissue morphology;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Nude Mice;Oncogenes;Oncogenic;Oncoproteins;Orphan;overexpression;Pathway interactions;Pharmaceutical Preparations;Play;Proliferating;protein complex;protein function;protein protein interaction;Proteins;RAD9A gene;Recurrence;Recurrent disease;replication stress;Reporting;Resistance;response;Role;Serous;Signal Transduction;Site;small molecule;small molecule inhibitor;small molecule libraries;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic development;Therapeutic Index;therapeutic target;Time;tumor;tumor growth;United States;Western Blotting;X-Ray Crystallography;Xenograft procedure

PROJECT_TITLE: Targeting RHNO1 in Ovarian Cancer


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Neurosciences;Pediatric

PI_NAMEs: IOSIF, ANA-MARIA  (contact)

PROJECT_TERMS: Address;Adolescence;Animal Model;Area;Basic Science;Behavior;Biological Models;Biometry;Biostatistics Core;Brain;Characteristics;Clinical;Collaborations;Consultations;Data;Data Analyses;Data Collection;Data Correlations;data dictionary;data quality;data sharing;Databases;design;Development;Education;education research;Ensure;epigenetic marker;experience;Experimental Designs;experimental study;Faculty;Funding;Genetic Markers;Goals;Grant;hands-on learning;Human;Human Resources;immune activation;Immunologic Factors;Individual;innovation;Knowledge;Leadership;Machine Learning;Manuscripts;Mental disorders;Mentors;Methodology;Mission;Modeling;multi-scale imaging data;Neuroimmunomodulation;next generation;novel;offspring;Preparation;Psychopathology;Publications;Quality Control;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Role;skills;sound;Statistical Data Interpretation;Statistical Methods;statistics;Students;Subgroup;Techniques;Testing;Training;Work;young adult

PROJECT_TITLE: UC Davis Conte Center: Biostatistics Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: NARRATIVE: Speech and language learning impairments have been linked to deficits in processing the complex spectral and temporal structure of sound. This project investigates cellular mechanisms of auditory perception in zebra finches, focusing on how early experience shapes the intrinsic physiological properties of neurons that may enable them to process rapid temporal modulations in vocalizations. Understanding these mechanisms will give insight into analogous processes in human speech development.

PI_NAMEs: MELIZA, CHAD DANIEL (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustic Stimulation;Acoustics;Affect;Area;Auditory;Auditory area;Auditory Perception;auditory processing;Auditory system;bird song;Birds;Brain;Cell membrane;Cells;Chick;Classification;Communication;Communication impairment;Complex;Cues;Data;design;Development;Developmental Communication Disorders;Developmental Process;Disease;Dyslexia;early experience;effective intervention;effective therapy;Electron Microscopy;Electrophysiology (science);Environment;experience;experimental study;Exposure to;extracellular;Face;Failure;Fire - disasters;Foundations;Goals;Hearing;Human;Immunofluorescence Immunologic;Impairment;in vivo;Infant;Injections;insight;Intrinsic drive;Language;Language Development;Language Development Disorders;Learning;Life;Link;Measurement;Measures;Membrane;Memory;Modeling;neural;neuromechanism;Neurons;Noise;noise exposure;Parents;Patients;Perception;Phase;Phonetics;Physiological;Poverty;Probability;Process;Property;Protein Analysis;protein expression;protein transport;Research;response;Role;Shapes;Signal Transduction;Slice;Social Environment;Songbirds;sound;specific language impairment;Speech;Speech Development;Speech Perception;Speech Sound;statistics;Stimulus;Structure;Systems Development;Testing;tutoring;vocalization;zebra finch

PROJECT_TITLE: Experience-dependent plasticity of auditory processing for vocal communication

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Genetics

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE We propose to investigate the role of transcriptionally generated G-quadruplex (G4), R-loop and DNA supercoiling in transcription and translation. Potential G4 forming sequences are prevalent in regulatory regions of human and e. coli genome and the G4 formation can up or downregulate gene expression including many oncogenes. Defining the molecular mechanism will contribute to the development of rational cancer drugs.

PI_NAMEs: MYONG, SUA  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: 5' Untranslated Regions;Address;Agreement;antibiotic G 418;Antineoplastic Agents;Biochemical;biochemical tools;Cell-Free System;Cells;cis acting element;Data;Dependence;Development;DNA;Escherichia coli;Excision;experience;G-Quartets;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Genomics;Goals;helicase;Human;Human Genome;Hybrids;In Vitro;Length;Measures;Mediating;Messenger RNA;Molecular;Molecular Conformation;Movement;Nucleic Acid Regulatory Sequences;Oncogenes;Output;plasmid DNA;Plasmids;Positioning Attribute;prevent;Process;Production;promoter;Promoter Regions;Proteins;recruit;Regulator Genes;Reporting;Research;Ribosomes;RNA;Role;single molecule;Slide;Sorting;Structure;Structure-Activity Relationship;Superhelical DNA;System;telomere;Telomere-Binding Proteins;Testing;Transcription Initiation Site;translational impact;Translations;Type I DNA Topoisomerases

PROJECT_TITLE: Gene Expression Modulated by G4, R-loop and DNA Supercoiling

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: ORANGEBURG

ORG_DEPT: BIOLOGY

ORG_NAME: CLAFLIN UNIVERSITY

ORG_STATE: SC

PHR: 8. Project Narrative The proposed Undergraduate-Research Initiative for Student Enhancement (U-RISE) at Claflin University (CU) consists of interdisciplinary research projects that 18 U-RISE Trainees will conduct under the supervision of a total of 15 researchers at CU and in collaboration with institutions that have research-intensive environments focusing on National Institutes of Health Training Programs over a five-year period. At CU, the project will be conducted in various laboratories (Biology, Chemistry, Mathematics-Computer Science and Engineering) in the School of Natural Sciences and Mathematics, with selected projects integrated with community-based participatory public health research to help address pertinent health disparities with collaborating external mentors. This project will enhance students’ enthusiasm in research and promote career development with an increased number of underrepresented students entering and completing Ph.D. or MD/Ph.D. programs in biomedical-focused sciences.

PI_NAMEs: ASSANIE-SHIVJI, SAMINA NOORALI;MCCUTCHEON, GLORIA S (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Address;African American;Area;Biology;career;career development;Chemistry;Collaborations;Communities;computer science;Cultural Sensitivity;Doctor of Philosophy;Education;Engineering;Environment;Faculty;faculty mentor;Female;First Generation College Students;Future;graduate school;health disparity;Historically Black Colleges and Universities;holistic approach;Humanities;Interdisciplinary Study;Internships;Interview;Journals;Laboratories;Manuscripts;Mathematics;matriculation;Mentors;Mentorship;Methodist Church;Minority Recruitment;Natural Sciences;Oral;posters;Preparation;programs;public health research;recruit;Research;Research Ethics;Research Personnel;Research Proposals;responsible research conduct;Schools;Science;Scientist;skills;South Carolina;STEM field;Strategic Planning;Students;Supervision;supportive environment;Training;Training Activity;Training Programs;undergraduate research;Underrepresented Students;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: U-RISE at Claflin University through Collaborative Interdisciplinary Mentoring in Biomedical Sciences

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: AT

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Palliative Care;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed study aims to develop a culturally relevant mind-body intervention for Black patients diagnosed with advanced cancer. Because the mind-body intervention improves quality of life and symptoms of cancer patients, the developed culturally relevant mind-body intervention will be promising to improve health and reduce health disparities in Black advanced cancer patients.

PI_NAMEs: CHO, DALNIM  (contact);MILBURY, KATHRIN

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Advanced Malignant Neoplasm;Area;arm;attentional control;Benchmarking;black patient;Black Populations;Black race;Cancer Control;cancer diagnosis;Cancer Patient;Cancer Survivor;care providers;Caregivers;Clinical;Cohort Studies;Compassion;Control Groups;coping;Data;Diagnosis;Disparity;Dose;effective intervention;Emotional;Exclusion;Faith;Family;Family Caregiver;Family member;feasibility testing;Future;gratitude;Health;Health Services Accessibility;Healthcare;improved;interest;Intervention;intervention delivery;Intervention Studies;Interview;Joints;Knowledge;Literature;Malignant Neoplasms;Meditation;meetings;Mind-Body Intervention;mind/body;mindfulness;Not Hispanic or Latino;Palliative Care;Participant;patient population;Patients;physical symptom;pilot test;Play;Population;population based;primary caregiver;primary outcome;Procedures;programs;Protocols documentation;psychoeducational intervention;psychological distress;psychological symptom;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Reduce health disparities;Reporting;Research;retention rate;Role;Sampling;Severities;Solid;success;Supportive care;Surveys;Survival Rate;Symptoms;Techniques;Testing;treatment arm;trial design;United States National Institutes of Health;Videoconferencing

PROJECT_TITLE: Randomized controlled trial to test feasibility of a culturally adapted meditation-based support intervention for Black patients dealing with advanced cancer


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Tuberculosis remains a leading cause of death around the world, and new treatments are needed to curb the epidemic. This work will help us understand the ways that non- protective immune responses are generated upon infection, allowing disease to be established. We anticipate that this work will facilitate future development of new anti- tuberculosis treatments.

PI_NAMEs: BARCZAK, AMY K (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Antitubercular Agents;arm;Bacteria;biological adaptation to stress;Cause of Death;Cells;Clinical Treatment;Complex;CRISPR/Cas technology;cytokine;Data;Development;Dimensions;Disease;Eicosanoid Production;endoplasmic reticulum stress;Enzyme-Linked Immunosorbent Assay;Epidemic;Equilibrium;Event;Future;Gene Expression Profile;Gene Expression Profiling;Genetic;Genetic Transcription;Growth;Histopathology;Human;human disease;Immune;Immune response;Immunologic Receptors;improved;in vivo;individual response;Infection;Infection Control;Inflammation;Inflammatory Response;Inhalation;innate immune pathways;Innate Immune Response;interest;Interferon Type I;Interferons;Interleukin-1;Knowledge;Link;Lipids;Literature;Lung;Macrophage;Measures;metabolomics;Microscopy;Mitochondria;Modeling;Molecular;mouse model;Mycobacterium tuberculosis;novel;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Patients;Play;Production;Productivity;recruit;response;Role;Sampling;Shapes;Signal Transduction;small molecule;small molecule inhibitor;Testing;Therapeutic;therapeutic target;Tissues;tool;Tuberculosis;tuberculosis treatment;uptake;Western Blotting;Whole Organism;Work

PROJECT_TITLE: Elucidating the path to type I IFNs in TB infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

ORG_CITY: DALLAS

ORG_NAME: BAYLOR RESEARCH INSTITUTE

PHR: NARRATIVE Older adults are at risk for ICU-acquired cognitive decline discernible from clinical, biological, and imaging- related changes in the brain following delirium and critical illness. Our Driving Rehabilitation and Innovation for Evaluating Risk in Post Intensive Care Unit Survivors (DRIVE-PICS) application seeks to implement in-vehicle kinematic driving data with neurocognitive assessments for essential formative work to develop data-based insights into driving behaviors. DRIVE-PICS is designed to contribute to a critical gap in health promotion to develop an evidence-based, in-vehicle driving assessment system to provide actionable driving safety data and rehabilitation strategies tailored to older ICU survivors, their care partners, and clinicians.

PI_NAMEs: DANESH, VALERIE  (contact);MCDONALD, ANTHONY D.

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Admission activity;Affect;Attention;automobile accident;Automobile Driving;Behavior assessment;behavior change;Behavioral;Biological;Brain;Caring;Clinical;clinical diagnosis;Cognitive;cognitive change;Cognitive deficits;cohort;Compensation;Complex;cost;Critical Illness;Data;Data Collection;Delirium;Dementia;design;Diagnosis;driving behavior;driving performance;driving safety;Employment;Enrollment;evidence base;experience;Funding;Future;Goals;health care service utilization;Health Promotion;high risk;Hospitals;Image;Impaired cognition;improved;innovation;insight;Intensive Care;Intensive Care Units;kinematics;Licensing;Life;life span;Measures;Monitor;Movement;Neurocognitive;Neurologic;normal aging;novel;older adult;older driver;Older Population;physical impairment;Physicians;post stroke;Predisposition;processing speed;programs;Protocols documentation;psychologic;Quality of life;Recovery;recruit;rehabilitation strategy;Rehabilitation therapy;Reproducibility;Research;response;Risk;Risk Factors;risky driving;Safety;safety assessment;sensor;skills;Special needs;Spinal cord injury;Strategic Planning;Stroke;success;Survivors;survivorship;Syndrome;System;Technology;therapy development;Time;United States;Universities;Vehicle crash;virtual;Visit;Work

PROJECT_TITLE: Driving Rehabilitation and Innovation for Evaluating Risk in Post-Intensive Care Unit Survivors (DRIVE-PICS)

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ATHENS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Public Health Statement There has developed a great need in contemporary society for veterinarians trained in the methodology of basic research but, unfortunately, veterinary students are often not aware of the career possibilities in these areas of need. The expansion of biotechnology frontiers require contributions by veterinary scientists capable of evaluating whole animal health issues while being expert, or at least conversant, with the rapidly evolving technologies. We believe our proposed training grant (third renewal) “Georgia Veterinary Scholars Summer Research Program” will make veterinary students more aware of and likely to pursue careers in research. Such veterinary research scientists will then be particularly well equipped to identify unique features of various animal models of human disease, to advance studies in translational medicine and animal health, to navigate the interface of animal and ecological health, and to be leaders in public health.

PI_NAMEs: SANCHEZ, SUSAN  (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: animal cloning;Animal Model;Animal Welfare;Animals;Area;Biology;Biomedical Research;biomedical scientist;career;college;Communication;Communities;comparative;Creativeness;design;Development;Discipline;Emerging Communicable Diseases;Environment;Ethics;Exercise;experience;Exposure to;Food Safety;Fostering;frontier;Future;Genes;Grant;Health;human disease;human model;Imagination;Journals;Medical;Medical Device;Mentors;Oral;Persons;pre-doctoral;programs;Public Health;recruit;Relaxation;Research;Research Personnel;responsible research conduct;Role;Scholars Program;Schools;Site Visit;skills;student mentoring;Student recruitment;Students;summer program;summer research;Talents;Time;Training;translational medicine;United States National Institutes of Health;Universities;Veterinarians;Veterinary Medicine;Writing


ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Cilia are tiny hair-like projections on the surface of the cell that can serve as antennae to sense the cell’s environment or beat to move fluid. Defects in cilia cause disorders known as ciliopathies that affect numerous organs, including the brain, kidneys, eyes, and lungs, which require cilia for their formation or function. The aim of this project is to understand how a newly discovered family of widely conserved, yet poorly understood, ciliary proteins contributes to cilia assembly and function.

PI_NAMEs: WINEY, MARK  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Adolescent;Affect;Axonal Transport;Behavior;beta Tubulin;biophysical analysis;Biophysics;Bos taurus;Brain;Cattle;cell motility;Cell Physiology;Cell surface;Cells;Centrioles;Centrosome;cerebrospinal fluid flow;Chlamydomonas;Chlamydomonas reinhardtii;Cilia;ciliopathy;cilium motility;comparative;Cryoelectron Microscopy;Defect;dimer;Disease;Distant;egg;Electron Microscopy;Environment;Epilepsy;Eukaryotic Cell;experimental study;Extracellular Fluid;Eye;Family;Functional disorder;Genetic;Goals;Hair;Human;Human Pathology;Hydrocephalus;improved;Individual;Infertility;Inherited;Juvenile Myoclonic Epilepsy;Kidney;kinetosome;Lead;Liquid substance;Lung;Mammalian Oviducts;Maps;Mediating;Microscopy;Microtubule Triplet;Microtubules;Mitosis;Motility;Movement;Mucous body substance;Mus;mutant;Myoclonus;Neurons;Normal Cell;novel therapeutic intervention;Null Lymphocytes;Organ;Organism;Orthologous Gene;Pathogenesis;Pathology;Pathway interactions;Phenotype;Play;Point Mutation;Polymers;Post-Translational Protein Processing;Predisposition;Primary Ciliary Dyskinesias;Process;protein function;protein structure;protein transport;Proteins;Proteomics;recruit;Resolution;rib bone structure;Role;Seizures;sex;Site;Sperm Motility;Stress;Structure;Tetrahymena;Tetrahymena thermophila;tool;trafficking;Tubulin;Vertebrates;Work

PROJECT_TITLE: MIPS (Microtubule Inner Proteins) function in cilia and basal bodies


NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Depression;Drug Abuse (NIDA only);Mental Health;Mental Illness;Natural Products;Neurosciences;Pain Research;Substance Misuse;Therapeutic Cannabinoid Research

PHR: A reason for the scarcity of safe and efficacious therapies these pain and comorbid depression is our limited knowledge of viable targets. In this project, we will use integrated positron emission tomography / magnetic resonance imaging to test the hypothesis that cannabidiol (CBD), compared to placebo, 1) reduces pain- and depression-related neuroinflammation, and 2) normalizes striatal function, in chronic low back pain patients. By studying the neural and neuroimmune responses to CBD, this study will advance our knowledge about the mechanisms of action of this drug, and help us understand which conditions might benefit the most from its use.

PI_NAMEs: GILMAN, JODI ;LOGGIA, MARCO LUCIANO (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Analgesics;Animals;Anterior;antidepressant effect;arm;Astrocytes;Beck depression inventory;Behavior;Behavioral;Brain;brain circuitry;Brief Pain Inventory;Cannabidiol;cannabinoid receptor;Cannabinoids;Cannabis;Chronic low back pain;chronic pain;cingulate cortex;clinical pain;Clinical Research;comorbid depression;comorbidity;Complex;Consumption;Corpus striatum structure;Data;depressive behavior;depressive symptoms;Disease;Dose;Double-Blind Method;drug action;efficacious treatment;Evaluation;Exhibits;FDA approved;financial incentive;Functional disorder;Functional Magnetic Resonance Imaging;Generations;glial activation;Heterogeneity;Incentives;Individual;Inflammatory;Investigational New Drug Application;Knowledge;Link;Magnetic Resonance Imaging;Maintenance;Marketing;Measures;Mediating;Mental Depression;Methodology;Microglia;MRI Scans;neural;Neuroglia;Neuroimmune;neuroinflammation;Pain;pain behavior;Pain management;pain model;pain patient;pain reduction;pain symptom;Pathway interactions;Patients;Peripheral;Pharmacology;Physiology;Placebos;Plants;Play;Positron-Emission Tomography;Pre-Clinical Model;preclinical study;Proteins;radioligand;Randomized;Reaction Time;Reporting;response;Rewards;Signal Transduction;Signaling Protein;Spinal Cord;Structure;Testing;Thalamic structure;Therapeutic;therapeutic target;United States

PROJECT_TITLE: Evaluation of Cannabidiol for Reduction of Brain Neuroinflammation

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: NARRATIVE Axons (the long cellular connections among nerve cells) typically fail to regrow when severed, leading to paralysis after spinal cord injury. We have discovered a series of compounds that promote the growth of axons in the brain and spinal cord. The goal of this proposal is to improve the properties of these compounds to generate candidate drugs that can be tested in clinical trials of injured patients.

PI_NAMEs: AL-ALI, HASSAN  (contact);BIXBY, JOHN L;LEMMON, VANCE P

PROGRAM_OFFICER_NAME: CYWIN, CHARLES L

PROJECT_TERMS: absorption;Address;Adult;analog;Animal Model;Animal Testing;Axon;axon growth;axon injury;axon regeneration;Biological Assay;Bladder;Brain;Breathing;Cells;Central Nervous System;central nervous system injury;Chemicals;Chemistry;Chronic;Clinical;clinical candidate;Clinical Trials;Complex;cost;Development;drug candidate;drug development;Drug Kinetics;Drug Targeting;Economic Burden;Effectiveness;Failure;Family;Generations;Goals;Growth;Health Insurance;Healthcare;Healthcare Systems;Heart;improved;In Vitro;in vivo;in vivo evaluation;Individual;inhibitor therapy;injured;Injury;Intellectual Property;International;Intestines;Investigation;kinase inhibitor;Lead;lead candidate;lead optimization;Legal patent;Machine Learning;Metabolism;Modeling;Motivation;Mus;Natural regeneration;neuron loss;Neurons;novel;novel therapeutic intervention;painful neuropathy;Paralysed;Patients;Persons;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Phenotype;Phosphotransferases;preclinical development;Property;Protocols documentation;psychologic;Rattus;Regenerative capacity;Reproducibility;Research;Risk;screening;Series;Sexual Dysfunction;small molecule;Source;Spinal Cord;Spinal cord injury;Structure-Activity Relationship;Synthesis Chemistry;Testing;Therapeutic;therapeutic candidate;Thinking;Toxic effect;Toxicology;translational potential;United States National Institutes of Health;Work

PROJECT_TITLE: Developing a kinase inhibitor drug to treat spinal cord injury


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Prevention

ORG_CITY: JACKSONVILLE

ORG_NAME: ENVIRONMENTAL MUTAGENESIS/GENOMICS SOC

PHR: Members of the Environmental Mutagenesis and Genomics Society (EMGS) have expertise in multiple disciplines covering all aspects of basic and applied research on mechanisms and consequences of responses to genotoxic agents. Integration of these disciplines remains the central focus of the Society, and the annual meetings are key to the dissemination of information and fostering of interactions between researchers and individuals who must make informed regulatory decisions with respect to environmental health hazards. Funding is being sought for these meetings to help provide a forum in which students, postdoctoral fellows, and early- stage investigators can develop and enhance their careers by sharing information with established scientists through formal scientific sessions and informal interactions.

PI_NAMEs: BEMIS, JEFFREY C (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Academia;Applied Genetics;Applied Research;Area;Award;Basic Science;Caliber;Canada;career;career development;cell injury;Cells;Chicago;Cities;Communities;Congenital Abnormality;cost;Data;Decision Making;Development;Discipline;Disease;disorder prevention;DNA;DNA Damage;DNA Repair;Doctor of Philosophy;Education;Educational workshop;Ensure;Environment;Environment and Public Health;environmental agent;Environmental Exposure;Environmental Health;environmental mutagens;Environmental Risk Factor;epidemiology study;Epigenetic Process;epigenome;Fees;Fertilization;Financial Hardship;Financial Support;Fostering;Foundations;Fox Chase Cancer Center;Funding;Future;Future Generations;Genetic;Genome;Genomics;genotoxicity;Goals;Government;Grant;Health;Health Hazards;Human;Individual;Industrialization;Industry;Information Dissemination;Inherited;interest;International;Knowledge;Lead;lectures;Malignant Neoplasms;meetings;member;Mission;Molecular;multidisciplinary;Mutagenesis;Mutagens;Mutation;National Institute of Environmental Health Sciences;Nerve Degeneration;Neurodegenerative Disorders;Organism;Outcome;Pathway interactions;Population;Postdoctoral Fellow;posters;Premature aging syndrome;prevent;Process;Professional Organizations;professor;Public Health;Public Relations;Reaction;Regulation;Research;Research Personnel;response;Risk Assessment;Role;Running;Science;Scientific Societies;Scientist;Societies;special interest group;Students;symposium;Tissues;Toxicogenetics;Toxicogenomics;Translational Research;Travel;Universities;Whole Organism

PROJECT_TITLE: 2023-2025 Annual Meetings of the Environmental Mutagenesis and Genomics Society (EMGS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 ARL-W (13)]


ADMINISTERING_IC: HG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Many researchers use DNA sequencing to study disease and biology, and analyzing this data requires sophisticated software capable of piecing together puzzles made of billions of fragments of DNA. Our main strategy for assembling these puzzles, aligning sequencing reads to a reference genome, suffers from the “reference bias” problem, where a lack of inclusiveness in the reference genome used causes it to give incorrect answers. We propose a new index data structure that tackles this problem while allowing for the extremely fast queries needed to keep up with fast DNA sequencers.

PI_NAMEs: LANGMEAD, BENJAMIN THOMAS (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TITLE: Efficient and scalable pangenomes with the move structure

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE This project charts the process of human biological niche construction: the formation of lived individual ecosystems at the intersection of genes, environment, & experience. We will measure genetic and environmental influence on social looking and brain growth in order to identify specific gene-by-environment- by-age transactions, transactions that typically canalize normative social development and that also offer the potential to identify optimal intervention targets to prevent or preempt the development of social disability.

PI_NAMEs: JONES, WARREN  (contact);SHULTZ, SARAH

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: Accounting;Adolescence;Affect;Age;Atlases;autism spectrum disorder;autistic children;behavior change;Behavioral;Behavioral Genetics;Biological;Birth;Brain;Child;Child Development;clinically significant;cognitive ability;cohort;Competence;Data;Development;Developmental Course;Dizygotic Twins;early childhood;Ecosystem;Enrollment;Environment;experience;Future;Genes;Genetic;Genetic study;Genetic Variation;Growth;Human;improved;Individual;infancy;Infant;insight;Intervention;Laboratories;late life;Learning;Life;Magnetic Resonance Imaging;Measures;Modeling;Monozygotic twins;Nature;Neurodevelopmental Disability;neuroimaging;Pathway interactions;Pattern;Personality;Phenotype;preempt;prevent;Process;prospective;psychologic;Research;Shapes;social;Social Behavior;Social Development;Social disability;social learning;spatiotemporal;Standardization;standardize measure;Testing;Therapeutic;Time;Transact;Twin Multiple Birth;Variant;Visual;visual tracking;Walking

PROJECT_TITLE: Measuring gene-environment transactions to identify sensitive periods for infant social behavior & brain growth

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Infectious Diseases;Maternal Health;Microbiome;Neurosciences;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Cesarean delivery, the most common major surgical procedure in the US, is the strongest risk factor for maternal infection (a top 3 cause of death during childbirth). Adjunctive azithromycin compared to standard antibiotic prophylaxis alone is proven (through our large C/SOAP trial and other studies) to be highly effective in preventing infection after cesarean - with authorities now recommending consideration of its use while calling for more information on long-term health outcomes after exposure at birth. We propose a US multi-center long-term follow- up study of children from the parent C/SOAP trial at age 7 (6-9) years to evaluate childhood obesity/growth and neurodevelopment after perinatal exposure to adjunctive azithromycin (complementing our NICHD grant evaluating pulmonary and gastrointestinal health scored at the 6th percentile); findings from this study will be used to inform and strengthen national and global health care policy regarding the safety of adjunctive azithromycin to reduce maternal infection after cesarean delivery.

PI_NAMEs: SUBRAMANIAM, AKILA  (contact)

PROGRAM_OFFICER_NAME: TAYLOR-ZAPATA, PERDITA

PROJECT_TERMS: 7 year old;Accounting;Address;Adoption;Adverse effects;Age;aged;American College of Obstetricians and Gynecologists;Antibiotic Prophylaxis;Antibiotics;antimicrobial;Asthma;authority;Award;Azithromycin;behavioral impairment;biobank;Biometry;biophysical properties;Birth;Breast Feeding;Budgets;Cause of Death;Cefazolin;Cephalosporins;Cerebral Palsy;Cesarean section;Cessation of life;Child;Childbirth;Childhood;cognitive ability;cohort;Cohort Studies;Companions;Complement;Cost Savings;Data;Diet;Dose;Endometritis;Enrollment;Exposure to;follow-up;Follow-Up Studies;Functional disorder;Functional impairment;Funding;Future;gastrointestinal;gastrointestinal function;global health;Grant;Growth;gut dysbiosis;Half-Life;Health;Health Care Costs;Health Policy;hospital readmission;Human Milk;Immune;Incidence;infant gut microbiome;Infection;Infection prevention;Inflammatory;Intervention;intrapartum;Life;Longitudinal Studies;Longterm Follow-up;Lung;Macrolides;male;Maternal Mortality;Measures;Mediating;Metabolic;Methods;microbiome research;Morbidity - disease rate;Mothers;Motor;National Institute of Child Health and Human Development;neonatal morbidity;Neonatal Mortality;neonatal outcome;neurodevelopment;neurodevelopmental effect;Neurodevelopmental Impairment;Newborn Infant;Obesity;obesity in children;obesity risk;offspring;Operative Surgical Procedures;Outcome;overweight child;Parents;Perinatal;Perinatal Exposure;Placebos;placental transfer;Population;Postoperative Period;prenatal;prenatal exposure;prevent;primary outcome;Prophylactic treatment;Puerperal Infection;pulmonary function;randomized trial;Recommendation;Reporting;Research Design;respiratory;response;Risk;Risk Factors;Safety;Site;social factors;Surgical incisions;Surgical Wound Infection;trial design;United States National Institutes of Health;Visit;Weight Gain;Woman;Wound Infection

PROJECT_TITLE: Childhood follow-up study of obesity and neurodevelopment after perinatal exposure to adjunctive azithromycin prophylaxis for cesarean delivery

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE In this project we search to validate the use of a new type of MRI technique, called Deuterium Metabolic Imaging (DMI) as a tool to detect abnormal glucose metabolism in brain tumors. We test the new technology by comparing with existing methods for validation, and also to reveal any improved performance. In addition, the use of DMI is evaluated as technique to detect early treatment effects in brain tumors.

PI_NAMEs: DE FEYTER, HENK  (contact);DE GRAAF, ROBIN A

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Achievement;Address;analog;Benchmarking;Brain;Brain imaging;Brain Neoplasms;brain tumor imaging;cancer cell;Cells;chemotherapy;Choline;Clinic;Clinical;Consumption;contrast imaging;Coupling;Deoxyglucose;Detection;Deuterium;Development;Diagnosis;Disease;Disease Management;Disease Progression;Dose;early detection biomarkers;Early Diagnosis;Evaluation;Evolution;Foundations;Future;Glioblastoma;Glucose;glucose metabolism;glucose uptake;Glutamates;Glutamine;Glycolysis;Goals;Image;Imaging Device;imaging modality;Imaging Techniques;Immune;improved;in vivo;Infusion procedures;insight;Label;Lesion;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Measurement;Measures;Metabolic;metabolic imaging;Metabolism;Methods;Monitor;N-acetylaspartate;neuro-oncology;new technology;Normal tissue morphology;oxidation;Oxygen;Pathway interactions;Patients;Pattern;Performance;Positron-Emission Tomography;Primary Brain Neoplasms;Process;Radioactive;Research;Research Project Grants;response biomarker;Rodent Model;Scanning;Signal Transduction;Solid Neoplasm;Staging;standard of care;technique development;Techniques;Technology;temozolomide;Testing;Time;Tissues;tool;treatment effect;treatment response;tumor;tumor growth;tumor metabolism;tumor progression;Tumor Volume;Validation;Visualization;Warburg Effect

PROJECT_TITLE: Validation of imaging brain tumor metabolism using deuterated glucose

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Digestive Diseases;Immunotherapy;Nanotechnology;Rare Diseases;Stomach Cancer;Women's Health Research

ORG_CITY: DAVIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative  Human epidermal growth factor receptor 2 (HER2) is overexpressed in over 20% breast cancers, and to a lesser degree in gastric cancers, colorectal cancer, ovarian cancers and bladder cancers. Here, we will develop a novel HER2-targeting transformable cancer targeting nanoplatform (TCTN) that not only can directly suppress HER2 dimerization and signaling leading to tumor cell death, but can also greatly augment systemic anti-tumor immune response.

PI_NAMEs: LAM, KIT S (contact)

PROGRAM_OFFICER_NAME: GRODZINSKI, PIOTR

PROJECT_TERMS: 4T1;Abscopal effect;anti-cancer;anti-PD1 antibodies;anti-tumor immune response;aqueous;Biodistribution;Blood Tests;Body Weight decreased;Breast Cancer cell line;Breast Cancer Model;cancer type;Cell Death;Cells;chelation;chemotherapy;Colorectal Cancer;Derivation procedure;design;Development;Dimerization;Disease remission;Dose;Epidermal Growth Factor Receptor;esterase;Esters;Future;Galectin 1;Hispanic;Homing;hormone therapy;Human;imaging modality;imaging system;Imiquimod;Immune;Immune response;immune stimulatory agent;Immunocompetent;Immunologic Adjuvants;Immunologic Stimulation;Immunotherapeutic agent;Implant;improved;In Situ;in vivo monitoring;inhibitor;innovation;Integrin alpha4beta1;Integrins;intravital imaging;Ligand Binding;Ligands;Light;Lighting;Macrophage;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of urinary bladder;Malignant Neoplasms;malignant phenotype;malignant stomach neoplasm;Mediating;Memory;Micelles;Modeling;Monoclonal Antibodies;Mouse Mammary Tumor Virus;Mus;nano;Nanodelivery;nanofibrillar;nanotechnology platform;nanotherapeutic;nanotherapy;neoplastic cell;novel;optical imaging;overexpression;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Peptides;Permeability;Pertuzumab;Phototherapy;Porphyrins;Positron-Emission Tomography;Proliferating;receptor;Regimen;Reporting;resiquimod;response;self assembly;side effect;Signal Transduction;Site;T-Lymphocyte;targeted treatment;Therapeutic Studies;Time;Transgenic Mice;translational potential;Trastuzumab;Treatment Efficacy;tumor;Xenograft Model;Xenograft procedure

PROJECT_TITLE: HER2-targeting transformable nanotherapeutic platform against HER2+ cancers


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Immunotherapy;Infectious Diseases;Malaria;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Vector-Borne Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

PHR: Most adjunctive treatments developed to date against cerebral malaria have not reduced fatal outcomes mainly because treatments have focused on clearance of circulating parasites but neglected the involvement of damaging parasite and host factors appearing early in infection or remaining after treatment. The proposed study uses 3D in vitro models, animal, and human studies to clarify our understanding of the role of NRG1/ErbB4 and PD1/PD-L1 signaling in HCM severity in order to target NRG1 in clinical trials with the ultimate goal of improving survival rates in children with cerebral malaria. The proposed study will clarify the role of NRG-1 in attenuation of ECM and human cerebral malaria (HCM) and mechanisms mediating its function.

PI_NAMEs: FORD, BYRON D.;STILES, JONATHAN K. (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: 3-Dimensional;Aftercare;Algorithms;Angiopoietin-2;ANGPT1 gene;Animal Model;Animals;Anti-Inflammatory Agents;Antibodies;Apoptosis;Apoptotic;artemether;Attenuated;attenuation;Autopsy;Behavioral;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Brain;brain dysfunction;Brain Edema;brain endothelial cell;Brain Injuries;brain tissue;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Culture Techniques;cell injury;Cerebral Malaria;Cerebrum;Cessation of life;Child;Chimeric Proteins;Clinical Trials;Cognition;Collaborations;Coma;Conscious;CXCL10 gene;Cytolysis;Dendritic Cells;Disease;disease prognosis;effectiveness evaluation;Encephalitis;Epithelial Cells;ErbB4 gene;Erythrocytes;Ethics;Extracellular Matrix;Falciparum Malaria;Fatal Outcome;Gene Expression;Genes;genetic variant;Goals;Heart failure;Heme;heme oxygenase-1;HRP-2 protein;Human;Human Experimentation;human induced pluripotent stem cells;human stem cell-derived;human subject;Impairment;improved;In Vitro;in vitro Model;Inbred BALB C Mice;Induced Neurons;induced pluripotent stem cell;Induction of Apoptosis;Infection;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Integration Host Factors;Interferons;Intravenous;Magnetic Resonance Imaging;Malaria;Matrix Metalloproteinases;Mediating;Microcirculation;Modeling;monocyte;mortality;Mus;neglect;Neuregulin 1;neurobehavioral;Neuronal Injury;Neuropeptides;neurovascular unit;Organoids;Parasites;Participant;Pathogenesis;PD-1 blockade;PD-1/PD-L1;Peptides;Peripheral Blood Lymphocyte;Phosphorylation;Plasmodium berghei;Plasmodium falciparum;Predisposition;Production;programmed cell death ligand 1;programmed cell death protein 1;prospective;Proto-Oncogene Proteins c-akt;receptor;Recovery;recruit;Regulatory Pathway;Reporting;Resistance;Role;Serum;Severities;Severity of illness;Signal Pathway;Signal Transduction;STAT3 gene;Survival Rate;Survivors;T-Cell Activation;T-Lymphocyte;tau Proteins;Testing;Therapeutic;Therapeutic Agents;Tissues;Translating;Urine

PROJECT_TITLE: Protective role of Neuregulin-1 against cerebral malaria-induced neuronal injury and behavioral sequelae


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Cancer;Childhood Leukemia;Clinical Research;Hematology;Mental Health;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Relevance to Public Health This project has relevance for public health because results will provide a more precise understanding of the long-term effects of chemotherapy on the developing brain, and shed light on the pathophysiology of chemotherapy-induced cognitive dysfunction, thus laying the foundation to improve the therapeutic index of cancer therapy by guiding clinical trials of protective interventions aimed at reducing the permanent burdens of curative treatment for leukemia.

PI_NAMEs: COLE, PETER D.;SUSSMAN, ELYSE S (contact);WAGSHUL, MARK E

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Acute Lymphocytic Leukemia;Age;Attention;Attentional deficit;behavior measurement;behavior test;Behavioral;Brain;brain dysfunction;cancer therapy;causal model;chemotherapy;Child;Childhood;Childhood Acute Lymphocytic Leukemia;Chronic;clinical outcome measures;Clinical Trials;Cognition;Cognitive;cognitive ability;Cognitive deficits;cognitive development;cognitive function;cognitive skill;curative treatments;Data;design;Development;Discrimination;efficacy testing;Electrophysiology (science);Event;executive function;Exhibits;Exposure to;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Impaired cognition;Impairment;improved;indexing;Inferior;Intervention;Leukemia Acute Lymphoblastic Chemotherapy;leukemia treatment;Link;Long-Term Effects;Longitudinal Studies;Measurable;Measures;Memory;Memory impairment;Modeling;multimodal data;neural;neural patterning;Neurocognitive;neuroimaging;Neurologic Process;neurophysiology;Neuropsychological Tests;neurotoxicity;novel strategies;Occupational;Outcome Measure;Pathway interactions;Patients;Pattern;Performance;Pharmacotherapy;Play;prevent;Prevention strategy;Process;Protocols documentation;Public Health;public health relevance;Quality of life;Research;Role;Schools;Sensory;sensory discrimination;Sensory Process;Severities;sex;Short-Term Memory;skills;Specificity;Standardization;Structure;Survivors;targeted treatment;Testing;Therapeutic Index;tool;treatment effect;treatment strategy

PROJECT_TITLE: Characterization of brain dysfunction during development in survivors of childhood acute lymphoblastic leukemia


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Scaling Up Research Ethics and Research Integrity (SURER) Project Project narrative  With increasing number and scope of research projects, the University of Maryland School of Medicine, Center for Bioethics and Research and University of Ibadan, Nigeria identified need to build capacity for mentored Responsible Conduct of Research (RCR), research/scientific integrity (RSI), Conflict of Interest (CoI), Diversity, Equity, and Inclusion (DEI), Safe Working Environment and Sexual Harassment training to strengthen research environment in Nigeria. We engage our successful training resources, technologies, and models to create new institutional resources and infrastructure, conduct advocacy, build public and professional awareness, implement training and innovative e-mentoring for RCR, RSI, CoI, DEI, Safe Working Environment and Sexual Harassment in sixteen Nigerian universities. We use the experiences and expectations of our trainees and use these to create a Learning Educational Program (LEP) with regular adjustments and updates to our curriculum contents and training examples.

PI_NAMEs: ADEBAMOWO, CLEMENT ADEBAYO (contact);ADEJUMO, ADEBAYO OLAYIWOLA;OGUNDIRAN, TEMIDAYO OLUSADE

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Advocacy;Advocate;Attitude;Awareness;Belief;Bioethics;Case Study;Collaborations;Conflict of Interest;Disease;Doctor's Degree;Education;Educational Curriculum;Environment;equity, diversity, and inclusion;Ethics;Ethics Consultation;expectation;experience;Growth;Humanities;Hybrids;Infrastructure;innovation;Institution;institutional capacity;International;Knowledge;Learning;Link;Maryland;Medical;medical schools;Mentors;Modeling;Needs Assessment;Nigeria;Nigerian;novel;Office Management;Persons;Procedures;Program Development;programs;repository;Research;Research Ethics;Research Personnel;Research Project Grants;Resources;responsible research conduct;scale up;Sexual Harassment;Technical Expertise;Technology;Training;Training Programs;Universities;Update;Variant;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(56)R]


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The third most common disease category in the U.S. after cancer and heart disease is autoimmune disease. Yet, treatments mainly rely on immunosuppressive drugs with significant side effects that are not curative and do not induce long term remissions. Our studies propose to reprogram neutrophils, abundant in blood and traditionally viewed as short-lived cells evolved to kill pathogens, into cells that re-educate autoreactive T cells to be tolerant to self-antigens, which in turn could reverse autoimmunity.

PI_NAMEs: MAYADAS, TANYA N (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Abbreviations;acquired immunity;American;ANCA vasculitis;Antibodies;antibody conjugate;Antigen Presentation;Antigen Presentation Pathway;Antigen-Antibody Complex;Antigen-Presenting Cells;Antigens;Antineutrophil Cytoplasmic Antibodies;Arginine;ATAC-seq;Autoantigens;Autoimmune Diseases;Autoimmunity;Autologous;Automobile Driving;autoreactive T cell;Binding;Biological Response Modifiers;Blood;Categories;CD8-Positive T-Lymphocytes;CD8B1 gene;cell killing;Cells;cellular imaging;ChIP-seq;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;Complex;CRISPR/Cas technology;Cross Presentation;cytokine;Data;Dendritic Cells;Deposition;design;Disease;Disease Outcome;Disease remission;Endocytosis;Endocytosis Induction;Endosomes;Epigenetic Process;epigenetic regulation;extracellular;Fluorescein-5-isothiocyanate;Frequencies;Generations;Genes;Genetic Screening;genetic signature;Genetic Transcription;Glomerulonephritis;Grant;Granulocyte-Macrophage Colony-Stimulating Factor;Heart Diseases;Histones;Human;humanized mouse;Hybrids;Immune;Immune system;Immune Tolerance;Immunity;immunogenic;Immunoglobulin G;Immunologics;Immunosuppressive Agents;in vivo;insight;Kidney;Knock-out;Lupus;Malignant Neoplasms;Mediating;MHC Class I Genes;Molecular;mouse model;Mus;neutrophil;Neutrophil Infiltration;novel therapeutic intervention;Ovalbumin;Ovum;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;patient subsets;Patients;Peroxidases;Pharmaceutical Preparations;Play;Population;programs;Property;Protein-arginine deiminase;proto-oncogene protein Spi-1;Regulation;Repression;response;Role;Route;Sampling;side effect;single-cell RNA sequencing;Stimulus;Systemic Lupus Erythematosus;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;trafficking;transcription factor;Tumor Immunity;validation studies

PROJECT_TITLE: Regulators of immune complex mediated neutrophil antigen presentation

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Rural Health;Social Determinants of Health;Suicide;Suicide Prevention

PHR: Sexual and Gender Minorities (SGM) living in rural areas and small cities in the United States are disproportionately affected by depression and suicide, yet little research has explored how pervasive and persistent experiences of SGM-related stigma, discrimination and trauma (i.e., distal minority stressors) may be associated with depression, suicide ideation, and suicide attempts among diverse rural SGM sub- populations. We will use online approaches to enroll 2000 rural SGM (500 each: cisgender sexual minority female, cisgender sexual minority male, transfeminine, and transmasculine persons) participants from across the US and administer repeat measures over 12 months to determine whether: classes of stigma, discrimination, and traumatic experiences vary across SGM subgroups; these exposures are associated with increased prevalent/incident depression, suicidal ideation, and suicide attempts; and if identity, psychological, and proximal minority stress related factors mediate and/or moderate these associations. Building on these findings, we will compare the relative acceptability of various technology-delivered intervention components for depression and suicide prevention that can be targeted to diverse rural SGM communities and their heterogenous experiences of distal minority stressors.

PI_NAMEs: MURRAY, SARAH SUTHERLIN-MCIVOR (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Age;Area;Baseline Surveys;cis-female;cis-male;cisgender;Cities;cognitive interview;cohort;Collaborations;Communication;Consultations;Country;Data;depression prevention;Development;Discrimination;Disparity;Distal;Enrollment;epidemiology study;ethnic identity;Ethnic Origin;evidence based guidelines;experience;experimental study;Feeling suicidal;Female;follow-up;Funding;Gays;gender minority community;gender minority group;gender minority health disparity;gender minority health research;General Population;Geography;Goals;Health;health disparity;Heterogeneity;Heterosexuals;high risk;improved;innovation;Institute of Medicine (U.S.);interest;Intervention;Intervention Studies;Investigation;Lesbian Gay Bisexual Transgender Queer;Life Cycle Stages;Literature;marginalization;Measures;Mediating;Mediator;men who have sex with men;Mental Depression;Mental disorders;Mental Health;Mental health promotion;Methods;metropolitan;minority stress;minority stressor;Modeling;Outcome;Participant;Pathway interactions;peer;Persons;Population;Population Programs;preference;Procedures;programs;prospective;Prospective cohort;protective factors;Psychiatric epidemiology;psychologic;Public Health Schools;Questionnaires;Race;Recommendation;Reporting;Research;Research Personnel;Risk Factors;Rural;rural area;rural counties;Sample Size;Sampling;Services;Sexual and Gender Minorities;sexual minority female;sexual minority group;sexual minority health;sexual minority male;social stigma;Strategic Planning;Subgroup;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Surveys;Technology;technology intervention;therapy development;Time;transfeminine;transmasculine;Trauma;United States;United States National Institutes of Health;Universities;young adult

PROJECT_TITLE: Prospective Cohort of Rural US LGBTQ Persons to Definitively Characterize Depression and Suicidal Ideation Burdens, Determinants, and Preferred Intervention Approaches

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma (PDAC) is in urgent need of therapeutic strategies that offer an improvement in clinical outcome and the targeting of cancer metabolism represents a promising approach in developing anti- cancer therapies. We have discovered that pH homeostasis is achieved in PDAC cells by employing the trans- Golgi network (TGN) as a “proton sink”, and we have developed a TGN pH biosensor assay for high-throughput (HT) screening of small molecules. The novel compounds that we identify will result in a loss of pH homeostasis and cancer-selective cell death, and may serve as chemical starting points to be further developed into safe and effective therapeutic agents for PDAC.

PI_NAMEs: COMMISSO, COSIMO  (contact);HEYNEN-GENEL, SUSANNE

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;analog;antiporter;Area;Biological Assay;Biological Models;Biosensor;cancer cell;Cancer Etiology;cancer therapy;cancer type;Cell Death;Cell membrane;cell transformation;Cells;Cessation of life;Chemicals;Clinical;Clinical Trials;Complement;Cytosol;cytotoxicity;Data Analyses;Death Rate;design;Development;Disease;Diversity Library;Ensure;extracellular;fitness;Future;Glycolysis;Golgi Apparatus;Grant;high throughput screening;improved;in vivo;inhibitor;innovation;Ion Transport;Ions;kinase inhibitor;lead optimization;Libraries;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Metabolic;Metabolism;miniaturize;Modality;mouse model;mutant;neoplastic cell;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Organelles;Outcome;overexpression;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;pH Homeostasis;Pharmaceutical Preparations;Play;prevent;Process;Production;Protons;Research;Role;scaffold;screening;small molecule;small molecule inhibitor;Stress Fibers;Structure-Activity Relationship;Survival Rate;Testing;Therapeutic;Therapeutic Agents;therapeutically effective;tool;trans-Golgi Network;tumor metabolism;United States;Validation;Warburg Effect;Work

PROJECT_TITLE: Discovery of Novel Inhibitors Targeting trans-Golgi Network Acidification in Pancreatic Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-W(55)R]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Nanotechnology

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE Dental enamel is unique in biology, as it is the only epithelial derived mineralized tissue and has a remarkable architecture based on extremely thin fibers of 50 nm in diameter that are woven into a fracture resistant and hard tissue for optimal mastication. This renewal application expands on a new paradigm that will decipher how the organic protein matrix of the developing enamel controls and guides enamel structure and will also initiates study towards the engineering of an enamel-like material in vitro.

PI_NAMEs: HABELITZ, STEFAN FRIEDRICH (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: 3-Dimensional;Acids;Adopted;Ameloblasts;amelogenin;Amino Acid Sequence;Amyloid;Apatites;Architecture;beta pleated sheet;Binding;Biological;Biology;Biomimetics;biomineralization;C-terminal;calcium phosphate;Carrier Proteins;copolymer;Cryoelectron Microscopy;Crystallization;Data;Dental Enamel;Dentin;Deposition;design;Development;Diameter;Enamel Formation;enamelin;Engineering;Epithelium;Event;Excision;experimental study;Extracellular Matrix;Family suidae;Fiber;Film;Fracture;Future;Growth;Habits;Histidine;Human;Hydrolysis;hydrophilicity;In Situ;In Vitro;in vitro Model;Ions;Length;Mastication;Metalloproteases;Methods;mineralization;Minerals;Modeling;Molecular;molecular modeling;Morphology;mouse model;nano;nanofiber;nanolithography;nanomaterials;nanometer;Pattern;Peptides;Phase;Phosphorylation;Polymers;Process;Protein Secretion;Proteins;Proteolysis;Recombinant Proteins;Recombinants;Resistance;Resolution;Role;scaffold;self assembly;Series;Specialized Epithelial Cell;Structure;Testing;Thinness;three dimensional structure;three-dimensional modeling;Tissues;X ray diffraction analysis

PROJECT_TITLE: Amelogenin Nanoribbons In Enamel Development And Engineering

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: PHOENIX

ORG_NAME: ARIZONA VETERANS RESEARCH AND EDUCATION FOUNDATION

PHR: Project Narrative Neurological disease (e.g., Alzheimer’s Disease and Related Dementias), injury (e.g., traumatic brain injury), and aging trigger inflammation that goes on to activate microglial immune cells in the brain. In this proposal, we develop molecular tools for the rod microglia variant, which follow the onset, progression, and resolution of neurological conditions. The tools will identify, isolate, and interrogate cell surface markers, genes, and proteins unique to this microglia variant, which can be used for diagnosis, prognosis, and potential treatment.

PI_NAMEs: LIFSHITZ, JONATHAN  (contact);STABENFELDT, SARAH E

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Actins;Address;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloidosis;Antibodies;antibody mimetics;antigen binding;Antigens;Autopsy;Binding;Biological;biomarker panel;Biomedical Engineering;Brain;Brain Injuries;Cd68;Cell Physiology;Cell surface;Cells;Chemical Exposure;Clinical;Collection;Cyclization;Cytoskeleton;Data;Data Set;Dendrites;design;Diagnosis;Diagnostic;differential expression;Diffuse Brain Injury;digital;Disease;disease model;Disease Progression;Epilepsy;Evolution;Experimental Models;Female;fluid percussion injury;Fluorescent in Situ Hybridization;Functional disorder;Future;Gene Expression;Genes;glial activation;Goals;Hand;Harvest;histological stains;Human;Immune;Immunohistochemistry;Impairment;Inflammation;Inflammatory;Injury;Intervention;Investigation;Knowledge;Laboratories;laser capture microdissection;Libraries;male;Mental disorders;Microglia;Microscopic;mimetics;Modeling;Molecular;Morphology;Motility;mouse model;Movement;nano-string;nerve injury;Nervous System Disorder;Nervous System Trauma;neural repair;Neurodegenerative Disorders;neuroinflammation;Neurologic;neuromechanism;neuronal cell body;Neurons;neuropathology;Paresis;Pathogenicity;Pathologic;Pathology;Pathway Analysis;Peptides;Phage Display;pharmacologic;Pharmacologic Substance;Phenotype;prevent;Process;Prognosis;prognostic;Proteins;Publications;Regional Disease;Regulation;repaired;Reporting;Research Project Grants;Resolution;RNA;Rod;Role;sex;Signal Induction;single-cell RNA sequencing;Site;Stroke;Structure;Surface;Swelling;Techniques;theories;Thick;Time;Tissues;tool;tool development;transcriptome sequencing;transcriptomics;Traumatic Brain Injury;Typhoid Fever;Variant;verification and validation;Visualization;Western Blotting

PROJECT_TITLE: Molecular Tool Development to Identify, Isolate, and Interrogate the Rod Microglia Phenotype in Neurological Disease and Injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Renal cell carcinoma (RCC), the 8th most common form of adult cancer in the US, is in need of novel therapeutic strategies to overcome resistance to existing therapies. My preliminary studies have revealed that deregulation of the Hippo-YAP/TAZ pathway represents a major molecular hallmark in RCC, and is a key mechanism used by RCC cells to maintain their transcriptional homeostasis. Employing patient-derived RCC tumor models and clinically viable inhibitors, my study will establish the therapeutic potential and mechanisms of actions for YAP/TAZ-based therapies in RCC.

PI_NAMEs: MCINTOSH, ALEC THOMAS (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Address;Adult;Affect;bHLH-PAS factor HLF;Binding;Cell Line;Cell Nucleus;Cessation of life;Clear cell renal cell carcinoma;Clinical;Clinical Trials;combat;Complex;confocal imaging;CRISPR interference;CRISPR/Cas technology;Data;Data Set;Development;Disease;DNA;Drug Targeting;Enhancers;Epigenetic Process;epigenomics;Fluorescent in Situ Hybridization;Generations;Genes;Genetic;genetic element;genetic signature;Genetic Transcription;Genomics;Growth;Harvest;Homeostasis;Immune checkpoint inhibitor;Immunofluorescence Immunologic;improved;In Vitro;in vivo;in vivo Model;industry partner;inhibitor;insight;Literature;Maintenance;Malignant Epithelial Cell;Malignant Neoplasms;mechanical signal;Mediating;Metastatic Renal Cell Cancer;Modeling;Molecular;mutant;Mutate;novel therapeutic intervention;novel therapeutics;Nutrient;Oncogenic;Oncoproteins;Oral;Output;Pathogenesis;Pathway interactions;Patients;pharmacologic;Phase;Phase I Clinical Trials;Phosphotransferases;Physical condensation;prevent;promoter;Protein Dephosphorylation;Regulatory Element;Renal Cell Carcinoma;Reporting;Resistance;Resolution;response;Scaffolding Protein;segregation;Signal Transduction;Site;small molecule inhibitor;targeted treatment;TAZ gene;Techniques;Technology;Testing;Therapeutic;therapy resistant;Tissue Microarray;Tissues;transcription factor;treatment effect;Treatment outcome;tumor;tumor microenvironment;United States;Xenograft procedure

PROJECT_TITLE: The Oncogenic functions of YAP/TAZ in Renal Cell Carcinoma


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Human Genome;Kidney Disease;Organ Transplantation;Prevention;Rare Diseases;Transplantation

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This application requests support to study predictors and immune signals of recurrent glomerular diseases after kidney transplantation. This research has the potential to refine the pathogenetic model of recurrent glomerular diseases, improve donor-recipient matching, and discover more effective therapies. Our goal is to reduce recurrent glomerular diseases and ultimately improve transplant survival.

PI_NAMEs: BATAL, IBRAHIM  (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Acute;Address;Allografting;Antibodies;Biopsy;Clinical Data;clinically relevant;cohort;Data;design;Development;Diffuse;Disease;disorder control;DNA;Donor Selection;effective therapy;Ensure;Failure;Fc Receptor;Focal and Segmental Glomerulosclerosis;follow-up;Future;Galactose;Gene Expression Profiling;Genetic;Genetic Models;Genetic Predisposition to Disease;Genetic Risk;genome wide association study;genome-wide;Genomics;Genotype;Goals;Health;IGA Glomerulonephritis;IgA1;Immune;Immune signaling;Immune Targeting;Immunoglobulin G;Immunologic Factors;Immunologic Monitoring;Immunotherapy;improved;Incidence;Individual;Inherited;Kidney;kidney allograft;Kidney Diseases;Kidney Failure;Kidney Transplantation;Mediating;member;Membranous Glomerulonephritis;Microanatomy;nano-string;nephrin;novel;Pathogenesis;Patient Monitoring;Patients;Phospholipase A2;Polysaccharides;post-transplant;precision medicine;Prognosis;Recurrence;Recurrent disease;Regimen;Renal glomerular disease;Request for Applications;Research;Research Personnel;Risk;Risk Factors;risk variant;Role;Secondary to;Serology;Serum;Signal Transduction;SNP array;Steroid-resistant idiopathic nephrotic syndrome;Steroids;Technology;Testing;transcriptomic profiling;transplant centers;Transplant Recipients;Transplantation;Tumor Necrosis Factor Superfamily Ligands;Up-Regulation

PROJECT_TITLE: Genetics and Immune Predictors for Recurrent Glomerular Diseases in the Kidney Allograft

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ORG_CITY: BOSTON

PHR: Using brain lesions and deep brain stimulation to identify an epilepsy circuit Focal epilepsy affects over 30 million patients worldwide and identifying the brain circuits involved in epilepsy can lead to better, more targeted treatments. Here, we use maps of human brain connectivity and a technique recently developed by our lab to identify the brain circuits connected to lesions causing epilepsy and brain stimulation sites treating epilepsy. Identification of these circuits will help identify lesion patients at highest risk for epilepsy, guide DBS programming, and provide a more precise therapeutic target for future brain stimulation trials.

PI_NAMEs: FOX, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Affect;Age;Amnesia;Anterior;Anticonvulsants;Atlases;Basal Ganglia;Brain;Brain Diseases;Brain hemorrhage;Brain Neoplasms;Cerebellum;Clinical;comparison control;connectome;Data;Data Set;Deep Brain Stimulation;Disease;Distant;Electrodes;Enrollment;Epilepsy;Freedom;Frequencies;Future;high risk;Human;implantation;improved;Intractable Epilepsy;Ischemic Stroke;Lesion;Location;Magnetic Resonance Imaging;Maps;Mental Depression;Metastatic malignant neoplasm to brain;neurosurgery;new therapeutic target;novel therapeutics;Parkinsonian Disorders;Partial Epilepsies;Patients;Penetrating Head Injuries;physically handicapped;post stroke;primary outcome;prospective;Registries;response;Risk;risk minimization;Seizures;sex;Site;Stroke;stroke outcome;stroke patient;stroke trials;Techniques;Testing;Thalamic structure;therapeutic target;Time;Trauma;Tuberous Sclerosis;tumor;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Using Brain Lesions and Deep Brain Stimulation to Identify an Epilepsy Circuit

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: Project Narrative Dementia with Lewy bodies (DLB) is a relatively common disorder that causes debilitating cognitive and psychiatric decline. No cure or effective therapies exist for these symptoms because the biological processes driving them are poorly understood. This project will analyze thousands of proteins in the brains and spinal fluid of individuals with DLB to better define its underlying biology and identify key proteins that can help us better monitor and treat this disease.

PI_NAMEs: HIGGINBOTHAM, LENORA  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: affective disturbance;alpha synuclein;Alzheimer's Disease;Alzheimer's disease brain;Amygdaloid structure;Anti-Anxiety Agents;Antipsychotic Agents;Area;Automobile Driving;Autopsy;Binding;biobank;Biochemical;Bioinformatics;Biological Markers;Biological Process;Biology;Brain;brain based;Cerebral cortex;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Cholinesterase Inhibitors;Clinical;Clinical Management;Co-Immunoprecipitations;Cognitive;comparison control;Competence;Complex;Data;Data Set;debilitating symptom;Dementia with Lewy Bodies;Deposition;Deterioration;Diffuse;Disease;effective therapy;Endothelium;experimental study;frontal lobe;Functional disorder;Funding;Goals;Impaired cognition;Individual;innovation;Laboratories;Link;link protein;Maps;Mass Spectrum Analysis;Measures;Mentors;Mentorship;Metabolic;Metabolic Pathway;Metabolism;Molecular;Molecular Profiling;Monitor;motor disorder;Nerve Degeneration;Neurobehavioral Manifestations;Neurologist;Neurons;neuropsychiatry;non-motor symptom;novel;novel marker;Observational Study;Parkinsonian Disorders;partial response;Pathogenesis;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Physicians;Pilot Projects;Precipitation;Preparation;Procedures;Process;Productivity;Protein Analysis;Proteins;Proteome;Proteomics;psychiatric symptom;Psychoses;Reproducibility;Research;Resources;Sampling;Scientist;stem;Symptoms;synuclein;synucleinopathy;System;Techniques;Temporal Lobe;Therapeutic;Tissues;Training;treatment response;Validation;Western Blotting;Work

PROJECT_TITLE: Identifying Pathophysiological Signatures of DLB Cognitive and Neuropsychiatric Decline Using a Systems-Based Proteomic Approach

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]