NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Prevention;Rehabilitation;Rural Health;Stroke

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative New treatments are urgently needed to treat, prevent, and promote recovery from stroke. We aim to continue to serve as a regional coordinating center in Stroke Net and conduct clinical trials in a regional network consisting of the hub at UTHealth in Houston and spoke stroke centers throughout Texas and Oklahoma. Our consortium provides stroke care to an incredibly diverse patient population in the South Central United States and has broad, multidisciplinary expertise in clinical trials for acute stroke, stroke prevention, and stroke recovery.

PI_NAMEs: SAVITZ, SEAN I (contact)

PROGRAM_OFFICER_NAME: MCCARTHY, SEAN PATRICK

PROJECT_TERMS: acute stroke;Adult;Anticoagulants;Applications Grants;Area;Attention;bench to bedside;Brain hemorrhage;career;career development;Caring;Cerebral hemisphere hemorrhage;Clinical Research;clinical research site;clinical trial participant;Clinical Trials;Coagulation Process;Collaborations;Conduct Clinical Trials;design;Development;Devices;disability;Disease;Education;Enrollment;Ensure;ethnic diversity;Ethnic Population;Impairment;Lead;Leadership;Link;Mentorship;metropolitan;Minority Recruitment;Multi-Institutional Clinical Trial;multidisciplinary;National Institute of Neurological Disorders and Stroke;novel;novel marker;novel therapeutics;Oklahoma;patient population;Patients;pediatric patients;Philosophy;Population Heterogeneity;pre-clinical;prevent;Productivity;programs;racial diversity;racial population;randomized trial;randomized, clinical trials;Recording of previous events;Recovery;recruit;Rehabilitation therapy;Research;research study;Retrieval;rural area;Scientist;Site;stem cells;Stroke;stroke patient;Stroke prevention;stroke recovery;stroke therapy;stroke trials;Testing;Texas;Training;United States;Woman;working group

PROJECT_TITLE: Gulf Regional Area Stroke Program and Oklahoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (17)]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Human communication evolved in a social context. Its natural ecology is face-to-face dyadic conversation, which entails mirroring of facial expression/gaze and spoken language, and rhythms in turn-taking. In this planning grant we convene a diverse multidisciplinary team, including ethicists, to develop and validate a tool for quantification of dyadic communication behavior across modalities, sensitive to temporal patterns, and computational frameworks for analysis. The tool will be both in-person and via remote platform.

PI_NAMEs: CORCORAN, CHERYL MARY (contact);GRINBAND, JACK ;PARVAZ, MUHAMMAD ADEEL

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TITLE: Interpersonal behavioral synchrony in virtual and in-person dyadic conversation

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SXC-N (O1)]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Social Determinants of Health;Stroke

ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE Stroke is a leading cause of disability and death that is affected by one’s socioeconomic status and race/eth- nicity. The New York City Collaborative Regional Coordinating Center (NYCC-RCC) will contribute to learning about stroke in high-risk and understudied patients. The NYCC-RCC has experience running and developing clinical trials and will leverage this expertise to discover new treatments and train the next generation of stroke researchers.

PI_NAMEs: LORD, AARON SYLVAN;MEHLER, MARK F;MOCCO, J DUFFY (contact)

PROJECT_TERMS: acute stroke;Adult;Affect;Area;care systems;career;career development;Caring;Cessation of life;Childhood;Childhood stroke;Clinical;Clinical Research;Clinical Trials;community engaged approach;community engagement;community partnership;comorbidity;Complement;Conceptions;Coupled;Data Collection;Data Science;design;Development;Dimensions;disability;Discipline;Disease;education planning;Educational Curriculum;Enrollment;Ensure;Epigenetic Process;Equity;Ethnic Origin;experience;Funding;Future;Health system;high risk;Improve Access;improved;Information Networks;Information Technology;Infrastructure;innovation;Institution;Investments;Leadership;Learning;Link;Maintenance;Mentorship;Mission;Modeling;mortality;New York City;next generation;novel;organizational structure;participant enrollment;Pathogenesis;Patients;pediatric patients;Performance;performance site;Population;Population Heterogeneity;Positioning Attribute;pre-clinical;Prevention;Process;Productivity;Program Development;programs;Race;recruit;regenerative;Rehabilitation therapy;Research;Research Personnel;Resolution;Resources;risk stratification;Running;Science;Site;Socioeconomic Status;stem cell therapy;stem cells;Stroke;stroke intervention;stroke patient;stroke risk;stroke therapy;stroke trials;StrokeNet clinical trials;Structure;Syndrome;Technology;Therapeutic;Thrombectomy;Time;Training;Training Programs;Translational Research;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Vocational Guidance;Vulnerable Populations


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CHICAGO

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

ORG_STATE: IL

PHR: The genome is stable in chronic myeloid leukemia (CML) compared to other myeloid malignancies, permitting long-term successful treatment with tyrosine kinase inhibitors (TKIs). However, with progression to blast crisis (BC), genomic instability increases. Also, ~50% of CML patients develop mutations in the CML-specific BCRABL oncogene that lead to TKI-resistance. We found aberrant activation of the innate immune response in human subjects and a murine model of CML. We also found enhanced reactive oxygen species production with efficient detoxification in CML until TKI-resistance or BC develop. The first goal of these studies is to determine the role of immune dysregulation in disease progression in CML. 50% of CML patients with a sustained, major molecular response to TKIs remain in remission after stopping these agents. Current clinical tools do not define who will relapse, but we found that interaction of CML cells with αβT cells predicted relapse after TKI-discontinuation. Our second goal is to determine if this interaction enhances leukemia cell persistence during TKI-treatment.

PI_NAMEs: EKLUND, ELIZABETH ANN (contact)

PROJECT_TERMS: abl Oncogene;Acceleration;Age;Antibodies;Bcr-Abl tyrosine kinase;Binding Sites;Blast Phase;Bone Marrow;CD34 gene;Cell Communication;Cells;Characteristics;Chromosomal translocation;Chronic Myeloid Leukemia;chronic myeloid leukemia cell;Chronic Phase;Chronic-Phase Myeloid Leukemia;Clinical;cohort;discontinuation study;Disease Progression;Disease remission;DNA Damage;Drug Metabolic Detoxication;Emergency Situation;Event;Failure;Funding;Generations;Genome;Genomic Instability;Goals;Granulopoiesis;Hematopoietic stem cells;Human;human subject;Immune;Impairment;inhibitor;Innate Immune Response;interest;knock-down;leukemia relapse;Leukemic Cell;leukemic stem cell;leukemogenesis;Mitochondria;Modeling;Molecular;molecular marker;molecular targeted therapies;mouse model;Mus;Mutagenesis;Mutation;Myeloproliferative disease;NADPH Oxidase;neutrophil;Neutrophilic Leukemia;pathogen;Pathway interactions;Patients;Phagocytes;Phagolysosome;Physiological;Point Mutation;Process;Production;progenitor;promoter;Protein Isoforms;Protein Tyrosine Kinase;Reactive Oxygen Species;Relapse;relapse patients;relapse prediction;Remission Induction;Resistance;response;Risk;Role;single-cell RNA sequencing;Source;standard of care;stem cell expansion;Stimulus;Stress;T-Lymphocyte;therapeutic target;therapy duration;tool;Transplantation;Tyrosine Kinase Inhibitor

PROJECT_TITLE: Identifying molecular markers that predict relapse after therapy discontinuation in chronic myeloid leukemia.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 HEMA-G (01)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Life expectancy is increasing worldwide and is expected to hit 90 years by 2030. Sarcopenia (the age-related loss of muscle mass and function), is associated with a high risk of morbidity-disability, decreased quality of life, increased burden of treatment and caregiving, and increased mortality. No medication is currently available to treat sarcopenia. Therefore, there is a substantial unmet clinical need for effective treatments of sarcopenia. Fortunately, we have identified a Chromogranin A peptide called Catestatin, which improved grip strength in older mice. In addition, we have identified a Catestatin mimetic small molecule pharmacophore TKO-10-18 that works in a similar fashion as Catestatin. The results obtained in older mice studies can then be translated to humans where these compounds can promote healthy rehabilitation by increasing grip strength and the resultant improvement in muscle function.

PI_NAMEs: MAHATA, SUSHIL K (contact)

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acetylcholine;adenylate kinase;Adult;Affect;age effect;age related;age related changes;age-related muscle loss;Aging;aging related disease;Amphiregulin;angiogenesis;Anti-Inflammatory Agents;AREG gene;Award;Axon;Biogenesis;Biological Products;Blood capillaries;caregiving;Characteristics;chemokine;cholinergic;Cholinergic Receptors;Chromogranin A;Clinical;cytokine;Cytoplasmic Granules;Data;density;Development;disability;Disease;Drug Kinetics;Economics;effective therapy;Electron Microscopy;Enzyme-Linked Immunosorbent Assay;Exhibits;frailty;Functional disorder;functional independence;Future;Gastrocnemius Muscle;Genes;Glucose Transporter;Glycogen;Half-Life;Hand Strength;Health;high risk;Human;improved;In Situ;in vivo evaluation;Inflammation;Interleukins;intraperitoneal;Knockout Mice;Lead;Legal patent;Life Expectancy;Link;Literature;Measures;mimetics;Mitochondria;Morbidity - disease rate;mortality;Mus;Muscarinic Acetylcholine Receptor;Muscle;muscle form;Muscle function;muscle regeneration;Muscle satellite cell;muscle strength;Neuromuscular Junction;novel therapeutics;old mice;Oral;Outcome;Pathway interactions;Peptides;Pharmaceutical Preparations;pharmacophore;Phenotype;Phosphorylation;Plasma;Play;Population;PPAR gamma;pre-IND studies;Presynaptic Terminals;Proliferating;Public Health;Publishing;Quality of life;Regulation;Regulatory T-Lymphocyte;Rehabilitation therapy;Risk;Role;Saline;sarcopenia;sciatic nerve;Signal Transduction;SIRT1 gene;small molecule;Societies;Soleus Muscle;Synaptic Vesicles;Testing;therapeutic target;Translating;transmission process;Visualization;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: Catestatin and its mimetic pharmacophore TKO-10-18 as potential therapies for age-associated muscle loss and the consequent frailty

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Here we seek to use mechanistic insights to develop a novel RNA-based approach targeting regulatory T cells as a potential therapy for acute myocarditis. We will investigate the mechanisms whereby a long noncoding RNA, BCYRN1, increases the proliferation, migration and activation of human regulatory T cells. Studies in a mouse model of virally-induced myocarditis will test whether BCYRN1, or shorter synthetic derivatives, will abbreviate the disease course, and/or decrease the severity, of acute myocarditis.

PI_NAMEs: MARBAN, EDUARDO  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Abbreviations;Acute;Acute Myocarditis;adaptive immune response;Advanced Development;Autologous;Binding;Biological Assay;Biology;Cardiac;cardiac regeneration;Cardiogenic Shock;Cardiomyopathies;cardioprotection;Cell Physiology;Cell Proliferation;Cell Therapy;Cells;Characteristics;Cholecystokinin;Clinical;Consumption;cost;Coxsackie Viruses;cytokine;Data;Dendritic Cells;Dilated Cardiomyopathy;Disease;disease model;Dissection;Dose;drug development;early phase clinical trial;Echocardiography;effective therapy;EFRAC;Elements;Enzyme-Linked Immunosorbent Assay;extracellular vesicles;FDA approved;Flow Cytometry;FOXP3 gene;Goals;Growth Factor;Guidelines;Heart;Heart failure;heart function;Heart Injuries;Histology;Human;Immune;Immunosuppressive Agents;improved;In Vitro;in vivo;in vivo evaluation;in vivo regeneration;Infiltration;Inflammatory;Infusion procedures;Injury;Innate Immune Response;insight;Insulin-Dependent Diabetes Mellitus;Interleukin-10;Luc Gene;Macrophage;Measures;Mediating;Medical;Methods;MicroRNAs;migration;Modeling;Molecular;mortality;mouse model;Mus;Myocarditis;Myocardium;neutrophil;novel;Nucleotides;organ transplant rejection;Patient Admission;Pharmaceutical Preparations;Porifera;pre-clinical;Production;Proliferating;Proteins;Recovery of Function;recruit;Regulatory T-Lymphocyte;Reporter Genes;Reporting;RNA;Rodent Model;Severities;Solid;Structure;success;Survivors;Symptoms;T-Lymphocyte;Testing;Therapeutic;Time;tissue repair;Transforming Growth Factor beta;Untranslated RNA;Ventricular Arrhythmia;Vesicle;Viral;Virus Diseases

PROJECT_TITLE: Regulatory T cell augmentation by a long noncoding RNA: mechanisms and therapeutic applications in myocarditis

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The NorCal-RCC (Regional Coordinating Center 13) leads a regional clinical trials network of site that are committed to conducting high-quality clinical research to improve stroke prevention, acute stroke treatment, and recovery from stroke as part of the NIH Stroke Net clinical trials network. The NorCal-RCC network engages with diverse populations of stroke patients to advance and accelerate stroke clinical research through its support of high-impact clinical trials in the regional and national network as well as its support of training for the next generation of leaders in stroke clinical research.

PI_NAMEs: KIM, ANTHONY SUYOUNG (contact)

PROJECT_TERMS: Acceleration;Active Sites;Acute;acute stroke;Asian Pacific Islander;Beds;California;career;career development;cerebral arteriopathy;Childhood stroke;Cities;Clinic;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Network;Communities;community engagement;County;COVID-19;Dedications;Education;Enrollment;Equity;experience;Faculty;Financial Support;Funding;General Hospitals;Goals;Hawaii;Health;Health system;Healthcare Systems;high risk;Hospitals;imaging biomarker;improved;Informed Consent;Infrastructure;innovation;Inpatients;Latino;Lead;Leadership;Medical center;Mission;multidisciplinary;National Institute of Neurological Disorders and Stroke;next generation;Participant;patient population;Patient Transfer;Patients;Pediatric Hospitals;Peer Review;Population;Population Heterogeneity;Prevention;Program Development;programs;Protocols documentation;Recording of previous events;Recovery;Registries;Rehabilitation therapy;Reporting;Research;Research Personnel;Research Training;Role;Salinas Valley;San Francisco;Science;Services;Site;Steroids;Stroke;stroke outcome;stroke patient;Stroke prevention;stroke recovery;stroke therapy;stroke trials;Stroke Volume;StrokeNet clinical trials;StrokeNet trials;success;System;telestroke;Thrombectomy;Training;Training Support;Translational Research;Translations;United States Department of Veterans Affairs;United States National Institutes of Health;Universities

PROJECT_TITLE: NIH StrokeNet- NorCal Regional Coordinating Center RCC13


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Wound Healing and Care

ORG_CITY: San Leandro

ORG_NAME: MERCATOR MEDSYSTEMS, INC.

PHR: RELEVANCE The changing demographics of Western societies include an aging population with a near epidemic of obesity, insulin resistance, and diabetes mellitus, causing a dramatic rise in the prevalence of peripheral artery disease (PAD) and its worst form, critical limb-threatening ischemia (CLTI), which impairs the ability to walk, causes pain, nonhealing ulcers and gangrene, and can lead to major amputations in the lower extremities. Among individuals most severely affected, revascularization of the lower extremities to restore circulation is the most effective therapy; however, to date, there has been no effective pharmaceutical strategy to reduce the incidence of restenosis due to intimal hyperplasia in below-the-knee (BTK) peripheral arteries. Therefore, the relevance of this proposal lies in its potential to improve patency of lower extremity interventions, reduce morbidity, and reduce the significant financial burden currently associated with the treatment of PAD and CLTI.

PI_NAMEs: SEWARD, KIRK  (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Address;Affect;Aftercare;Age;aging population;American;Amputation;analog;Ankle;antiproliferative drugs;Area;ARNT gene;Arteries;artery occlusion;Balloon Angioplasty;Blinded;Blood flow;Blood Vessels;Bypass;Catheterization;Catheters;cell motility;Chemistry;chronic ulcer;Circulation;Clinical;Clinical Protocols;Clinical Trials;clinically relevant;Code;Combined Modality Therapy;comorbidity;Contracts;Controlled Clinical Trials;Data;demographics;design;Development;Devices;Diabetes Mellitus;Disease;Distal;Dose;Drug Delivery Systems;effective therapy;Effectiveness;efficacy evaluation;Enrollment;Failure;FDA approved;Feedback;Financial Hardship;follow-up;foot;Formulation;Freedom;Freeze Drying;Funding;Gangrene;Goals;Good Manufacturing Process;Grant;Human;Hyperplasia;Impairment;improved;Incidence;Individual;Infusion procedures;innovation;Insulin Resistance;Intervention;Ischemia;Kinetics;Knee;Laboratories;Lead;Left;Leg;Legal patent;Lesion;Limb structure;liquid formulation;Lower Extremity;manufacture;manufacturing organization;Medial;Mediation;Morbidity - disease rate;Needles;New Drug Approvals;novel;Obesity Epidemic;Operative Surgical Procedures;Outcome;Pain;Participant;Patients;Pericytes;Peripheral;Peripheral arterial disease;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Phase;Phase II Clinical Trials;Phase III Clinical Trials;phase III trial;Phenotype;Placebos;Prevalence;prevent;Prevention;primary endpoint;Procedures;Production;Proliferating;Protocols documentation;Rana catesbeiana;Randomized;Randomized, Controlled Trials;Recovery;Research;Resources;restenosis;revascularization;Safety;Sample Size;Signal Transduction;Sirolimus;Small Business Innovation Research Grant;Smooth Muscle Myocytes;Societies;Solid;Stenosis;Stents;Structure of popliteal artery;success;Superficial Femoral Artery;surgical risk;Survival Rate;Techniques;Testing;Therapeutic;Tissues;Toes;Translating;Tunica Adventitia;Ulcer;United States Centers for Medicare and Medicaid Services;Vascular blood supply;Vascular remodeling;Walking

PROJECT_TITLE: Improved Sirolimus-Analog Adventitial Delivery to Enhance Outcomes in Below-the-Knee Peripheral Artery Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (O1)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Emergency Care;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Substance Misuse;Telehealth;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: LAS VEGAS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: PROJECT NARRATIVE 683,000 women are sexually assaulted annually in the United States, half of whom develop chronic posttraumatic stress disorder (PTSD) and thus have markedly increased risk for cannabis use disorder (CUD). The current proposal will test the acceptability, initial efficacy, and mechanisms underlying a novel digital therapeutic targeting risk for PTSD-CUD, which could address the critical need for PTSD-CUD prevention for the 100,000 women who annually present for emergency care after sexual assault. In this research context, the applicant will receive key training in multisite, emergency-care based RCTs, advanced statistical analyses for RCTs and ecological momentary assessment data, biobehavioral mechanisms underlying PTSD-CUD prevention, and professional development, launching her independent research career focused on reducing the public health burden of PTSD-CUD among sexual assault survivors by leveraging digital therapeutics.

PI_NAMEs: SHORT, NICOLE AMAI (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Accident and Emergency department;Address;Adverse effects;Affect;American;Anti-Anxiety Agents;Anxiety Disorders;anxiety reduction;anxiety sensitivity;anxious;Arousal;assault;Attenuated;Automobile Driving;biobehavior;Cannabis;cannabis craving;career;Caring;Cellular Phone;Chronic Post Traumatic Stress Disorder;Clinical;Clinical Trials;clinically significant;Cognitive Therapy;Cohort Studies;comorbidity;computerized;cost;craving;cue reactivity;Cues;Dangerousness;Data;design;Development;digital;digital treatment;Disease;disorder prevention;Distress;Ecological momentary assessment;efficacious treatment;efficacy evaluation;Emergency Care;Emergency Situation;Fright;Incidence;Intervention;Intervention Studies;Knowledge;marijuana use;marijuana use disorder;Measures;Mental Health;Mentors;Methods;Modeling;modifiable risk;Modification;National Institute of Drug Abuse;novel;observational cohort study;Observational Study;Outcome;Patient Self-Report;physical conditioning;Physiological;post-trauma;Post-Traumatic Stress Disorders;Pregnancy;prevent;Prevention approach;Preventive;preventive intervention;prospective;psychoeducation;Public Health;Randomized;Relaxation;Reporting;Research;response;Risk;Risk Factors;Severities;sexual assault;Sexually Transmitted Diseases;Site;skills;Statistical Data Interpretation;substance use;Surveys;Survivors;Symptoms;targeted treatment;Technology;Testing;therapeutic target;Training;Training Programs;Trauma;Treatment Efficacy;Treatment outcome;treatment strategy;United States;usability;Visit;wearable device;Woman;Work;Wrist

PROJECT_TITLE: Development of a digital therapeutic targeting anxiety sensitivity to reduce PTSD-SUD in women presenting for emergency care after sexual assault.

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ORG_CITY: COLUMBIA

ORG_NAME: HARRY S. TRUMAN MEMORIAL VA HOSPITAL

ORG_STATE: MO

PHR: Project Narrative Blast-induced mild traumatic brain injury (mTBI) can cause long-term disabilities in service personnel exposed to blast in combat or during military training. These disabilities impose socioeconomic burdens on patients, families, and society. Using an established, highly reproducible open-field blast mouse model, our studies demonstrated ability for the high-energy blast waves to rupture membranes and intracellular components in the brain tissue. This project is aimed at investigating mechanism(s) of the signature ‘invisible injury’ sustained in affected service personnel. Using a transgenic mouse model expressing human tau, studies will further examine the role of tau on key linkages between low-level blast exposure(s) and underlying ultrastructural damage as well as molecular changes reflecting oxidative stress and mitochondrial dysfunction. Understanding of the pathogenesis of mTBI-induced cognitive deficits due to blast will advance opportunities for preventative and treatment strategies.

PI_NAMEs: GU, ZEZONG  (contact)

PROJECT_TERMS: Acceleration;Affect;Afghanistan;Alzheimer's Disease;Alzheimer's disease pathology;Animal Model;Anxiety;Area;Autopsy;Axon;Behavior;Behavior assessment;Behavioral;Biochemistry;Bioenergetics;biological adaptation to stress;Biological Markers;biomarker discovery;blast exposure;Blast Injuries;Brain;Brain imaging;brain tissue;cell type;Cells;chronic traumatic encephalopathy;Classification;Cognitive;Cognitive deficits;combat;Defect;Department of Defense;Development;disability;Discipline;Economic Burden;Etiology;Evaluation;Exposure to;Family;functional outcomes;head impact;hTau Mice;Human;Human Resources;Imaging Techniques;Immunohistochemistry;Impairment;in vivo;in vivo imaging;inhibitor;Injury;insight;instrumentation;Intention;Investigation;Iraq;Laboratories;Lead;Lifelong disability;Link;Long term disability;Mediating;Membrane;Metabolic;metabolic profile;meter;mild traumatic brain injury;Military Personnel;Missouri;Mitochondria;mitochondrial dysfunction;Molecular;Molecular Biology;molecular imaging;mortality;mouse model;Mus;Myelin;Neurodegenerative Disorders;Neurologic Deficit;neuropathology;neuropsychiatric disorder;Outcome;Oxidative Stress;Pathogenesis;Pathologic;Pathology;Patients;Plasma;Positioning Attribute;Positron-Emission Tomography;pressure sensor;Prevention;Prevention strategy;Prone Position;Protocols documentation;Reporting;Reproducibility;Research;research facility;Research Personnel;response;Role;Rupture;Scanning;service member;Services;Sex Differences;single photon emission computed tomography;Societies;socioeconomics;Speed;Stains;System;Systems Biology;tau aggregation;tau expression;tau Proteins;tau-1;Tauopathies;Techniques;Testing;Time;Training;Transgenic Mice;Transmission Electron Microscopy;Traumatic Brain Injury;treatment strategy;Universities;Validation;Veterans;Veterans Hospitals;War;white matter;wound

PROJECT_TITLE: CTBI: Tauopathy in Mice and Human: Effects of Open-Field Low-Intensity Blast on Brain Ultrastructure and Outcomes in Mild Traumatic Brain Injury


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Hematology;Lymphatic Research;Lymphoma;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: The current treatment for brain tumors is often not effective and causes substantial side-effects. Molecular profiling of these tumors in recent years has uncovered genetic alterations which may render them sensitive to drugs targeting these alterations. The goal of our research program is to determine how to exploit these potential vulnerabilities with new drugs.

PI_NAMEs: MELLINGHOFF, INGO K (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: Adult;Agammaglobulinaemia tyrosine kinase;Biopsy;Brain Neoplasms;Central Nervous System Lymphoma;chemotherapy;Clinical;Combined Modality Therapy;Development;Drug resistance;Drug Targeting;Epidermal Growth Factor Receptor;Evaluation;Evolution;Genetic study;Glioblastoma;Glioma;Goals;Human;Impaired cognition;inhibitor;Isocitrate Dehydrogenase;Knowledge;Maintenance;Malignant Neoplasms;Modeling;Molecular;Molecular Profiling;mutant;Mutation;novel therapeutics;oncogene addiction;Oncogenic;Operative Surgical Procedures;Pathway interactions;Patients;Pharmacology Study;Phosphotransferases;Primary Brain Neoplasms;programs;Radiation therapy;Research;side effect;Signal Pathway;Signal Transduction;targeted treatment;Therapeutic;Toxic effect;tumor;tumor heterogeneity

PROJECT_TITLE: Molecular Mechanisms of Drug Resistance in Primary Brain Tumors


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Mental Illness;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Exercise offers great potential as a first-line, formally prescribed intervention for anxiety disorders, but research is needed to improve exercise engagement, establish the optimal titration for exercise prescriptions, and identify which mechanisms to target to optimize outcomes in practice. This Career Development Award project examines a novel exercise titration method as compared to low intensity exercise with objective assessment of heart rate based intensity goals (as target engagement), assessment of real-time changes in mood following exercise (through ecological momentary assessment), neuroeconomic assessment of exercise decision-making, and their association with anxiety and adherence outcomes in sedentary individuals with a primary anxiety disorder and moderate to high anxiety sensitivity. Findings will inform optimal exercise titration methods as well as identify potential mechanisms to support the development of personalized approaches to prescribing exercise as an evidence-based intervention for anxiety.

PI_NAMEs: SZUHANY, KRISTIN L. (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Achievement;Address;Adherence;Adult;Affect;American;Anxiety;Anxiety Disorders;anxiety sensitivity;anxiety symptoms;anxiety treatment;Area;Biological Assay;Blinded;career;Caring;Clinical;college;Computer Models;cost;Data;Data Analyses;Decision Making;Development;Diagnostic;Dose;Ecological momentary assessment;Esthesia;evidence base;Evidence based intervention;Exercise;exercise intensity;exercise intervention;exercise prescription;Exercise Therapy;Exposure to;flexibility;follow-up;Fright;Future;Goals;Grant;Growth;Guidelines;Heart Rate;Human;Impairment;improved;Individual;Intervention;Investigational Therapies;K-Series Research Career Programs;Machine Learning;Maps;Maximum Heart Rate;Measures;Mediator;Medicine;meetings;Mental Health;Mentors;Mentorship;Methods;Modeling;Moods;Movement;National Institute of Mental Health;neuroeconomics;Neurologic;neuromechanism;novel;Outcome;overtreatment;Participant;Patients;personalized approach;Pharmaceutical Preparations;physical conditioning;Physiological;Positioning Attribute;positive mood;precision medicine;Psychiatry;psychologic;Psychotherapy;Randomized;Recommendation;Research;Research Personnel;response;sedentary;Severities;side effect;Sports Medicine;Standardization;Symptoms;Techniques;Time;Titrations;Training;Work

PROJECT_TITLE: Optimizing Exercise for the Treatment of Anxiety


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: WHITERIVER

ORG_NAME: WHITE MOUNTAIN APACHE TRIBE

ORG_STATE: AZ

PHR: PROJECT NARRATIVE: The White Mountain Apache-JHU NARCH XI builds on our 40-year partnership addressing tribal health disparities and promoting tribal health autonomy. For NARCH XI, Apache students and faculty will receive training in public health, biomedical and behavioral sciences, and develop applied skills through three research studies addressing: Staphylococcus aureus; drug and alcohol use; and, breast cancer screening.

PI_NAMEs: CRAIG, MARIDDIE J (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Academic Training;Address;Alaska Native;Alcohol consumption;Alcohols;American Indians;Apache;Apache Indians;Apache Tribe;Applied Skills;Behavioral Sciences;Breast Cancer Detection;brief intervention;cancer care;Clinic;combat;Communities;community advisory board;community based participatory research;cultural competence;culturally appropriate intervention;Data Collection;design;Development;Diagnosis;Discipline;Disease;Drug usage;Education;Evaluation;evidence base;experience;Faculty;Goals;Grant;Health;health disparity;Health Priorities;Health Promotion;high risk;improved;Indian reservation;Individual;innovation;Institution;intergenerational;Intervention;Knowledge;Lead;life span;Measures;Mentors;Methodology;Methods;Modeling;Motivation;Native American Research Center for Health;Opioid;Outcome;Output;Phase;prevent;programs;protective factors;Provider;Public Health;public health intervention;Research;Research Methodology;Research Personnel;Research Project Grants;research study;Research Training;Resources;Risk;Scientist;skills;Staphylococcus aureus;Structure;Students;substance use;Teacher Professional Development;therapy design;therapy development;Time;tool;Training;tribal health;Tribes;Universities;Vulnerable Populations;White Mountain Apache;Woman

PROJECT_TITLE: WMAT-JHU NARCH XI Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y(55)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

PHR: PROJECT NARRATIVE: NARCH XI will build on the successful partnership between WMAT and JHU to advance the tribe's sovereignty in health research and education. We are creating a future where community members will lead our health agencies and research agenda. NARCH has been a way to change research from a tool that once exploited Native people to an agent of change for future health and well-being.

PI_NAMEs: BARLOW, MARY ALLISON (contact)

PROJECT_TERMS: Address;Alcohols;Ally;Apache;Apache Tribe;binge drinking;Breast Cancer Detection;brief intervention;Communication;Communities;community advisory board;community engaged intervention;Data;design;Diagnosis;Drug usage;Education;Evaluation;experience;Faculty;Future;Goals;Health;improved;Information Dissemination;Interdisciplinary Study;Intervention;Lead;member;Mentors;Monitor;Native American Research Center for Health;Native-Born;Opioid;Personal Satisfaction;Process;Reporting;Research;Research Project Grants;Research Training;Resource Development;Resources;Risk;Safety;Staphylococcus aureus infection;Strategic Planning;Structure;Students;substance use;Teacher Professional Development;Technical Expertise;tool;Training;training opportunity;tribal health;tribal lands;tribal leader;tribal member;Tribes;Universities;White Mountain Apache;White Women;Woman;Youth

PROJECT_TITLE: NARCH XI White Mountain Apache Tribe (WMAT)- Johns Hopkins University (JHU) Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Opioids;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Underage Drinking

PHR: PROJECT NARRATIVE The Apache-JHU Bright Horizons study will conduct qualitative research in collaboration with a Community Advisory Board to design and evaluate the impact of a brief alcohol use intervention for adolescents who have engaged in recent severe drinking through a randomized controlled trial. The intervention will be delivered by Apache Community Mental Health Specialists to address cultural and logistical barriers to care and build local capacity in alcohol use interventions and research methods. This study will address critical public health needs—the rise of severe alcohol use nationally, the prevalence of polysubstance use, and the impact of the current COVID pandemic on alcohol and drug use—by targeting risk and protective factors identified through previous community-driven research.

PI_NAMEs: CWIK, MARY  (contact)

PROJECT_TERMS: 17 year old;acceptability and feasibility;Acute;Address;Adolescent;Adult;Age;Aggressive behavior;alcohol abstinence;Alcohol consumption;alcohol-related death;Alcohol-Related Disorders;Alcohols;American Indian Population;Apache;Apache Tribe;Attention;barrier to care;behavioral health;binge drinking;brief intervention;Case/Control Studies;Cognitive Therapy;Collaborations;Communities;community advisory board;Community Participation;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;culturally appropriate intervention;Data;data management;Decision Making;design;deviant peer;Disparity;drinking;Drug usage;Educational Curriculum;Educational process of instructing;effectiveness testing;Elements;emotion regulation;Enrollment;Ethics;ethnic minority;Evidence based intervention;experience;Family;follow-up;Foundations;Friends;Funding;Goals;Grant;Home;Impulsivity;Indigenous;Individual;innovation;Intervention;intervention participants;Interview;Knowledge;Literature;Master of Science;member;Mental Health;Mental Health Services;Mentors;Modeling;mortality;motivational enhancement therapy;Native American Research Center for Health;Native Americans;native youth;Native-Born;neighborhood disadvantage;novel;Opioid;opioid use;Participant;Pattern;peer;Peer Pressure;Persons;Phase;polysubstance use;Population;post intervention;Prevalence;preventive intervention;Problem Solving;Process;programs;protective factors;Public Health;Qualitative Methods;Qualitative Research;Race;Randomized, Controlled Trials;Reporting;Research;Research Methodology;Research Personnel;research study;Risk;Risk Factors;Schools;Self-Injurious Behavior;Series;service delivery;Severities;skills;Social Problems;Specialist;substance abuse prevention;substance use;substance use prevention;Suicide;System;Techniques;Theoretical model;therapy design;therapy development;Time;tool;Training;tribal health;Tribes;White Mountain Apache;Youth

PROJECT_TITLE: Bright Horizons: Designing and Evaluating a Brief Intervention to Address Alcohol, Opioid, and other Substance Use among At-Risk Apaches


NIH_SPENDING_CATS: American Indian or Alaska Native;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

PHR: PROJECT NARRATIVE In the Southwest United States, the American Indian population is disproportionately affected by morbidity and mortality related to Staphylococcus aureus infections. Existing strategies have not been sufficient to control S. aureus disease and new approaches are urgently needed. This proposal will address this public health need by designing and evaluating a community-informed approach to education and decolonization to prevent S. aureus disease among high-risk individuals that could be adapted and replicated in other American Indian populations.

PI_NAMEs: HAMMITT, LAURA  (contact)

PROJECT_TERMS: 2 year old;acceptability and feasibility;Address;Adherence;Adult;Affect;American Indian community;American Indian Population;American Indians;Amputation;antimicrobial;Apache Tribe;Applied Research;Bacterial Infections;behavior change;Cessation of life;Clinic;Collaborations;Communicable Diseases;Communities;community engaged intervention;Control Groups;cost;Data;Data Analyses;design;Development;Diabetes Mellitus;Disease;Disparity;Education;Educational Materials;efficacy evaluation;Enrollment;experience;Focus Groups;Goals;Health;Health Personnel;Healthcare Systems;high risk;high risk population;Hospitalization;hospitalization rates;Household;Incidence;inclusion criteria;indexing;Individual;Infection;Infectious Skin Diseases;Intervention;Interview;Knowledge;Licensure;Local Anti-Infective Agents;member;Mentorship;methicillin resistant Staphylococcus aureus;Methodology;Morbidity - disease rate;mortality;Native American Research Center for Health;Necrotizing fasciitis;novel strategies;Outcome;Participant;patient population;Patients;Periodicals;Persons;Pneumonia;Population;Prevalence;prevent;Prevention;primary outcome;Protocols documentation;Public Health;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Recurrence;recurrent infection;Regimen;Reporting;Research;Resource-limited setting;Rural;rural Americans;secondary outcome;Sepsis;Services;Soft Tissue Infections;Staphylococcus aureus;Staphylococcus aureus infection;Time;Training;trend;tribal community;tribal lands;tribal member;United States;United States Indian Health Service;Vaccines;Visit;Water;White Mountain Apache;Work

PROJECT_TITLE: Community-informed interventions to address the large burden of Staphylococcus aureus infections on the White Mountain Apache Tribal lands


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse;Telehealth;Women's Health Research

PHR: PROJECT NARRATIVE The overall goal of this research is to develop, implement and evaluate scalable, culturally relevant interventions to improve breast cancer screening and, ultimately, stage of diagnosis and survival among White Mountain Apache (WMA) women. This study leverages recent formative data collection and community readiness for intervention; and is designed to produce evidence-based scalable interventions for American Indian and other rural populations to improve breast cancer survival rates in settings that are at increasing risk for breast cancer and have lower survival rates.

PROJECT_TERMS: Address;Age;aged;Alaska Native Women;American Indian Women;American Indians;Apache;Arizona;arm;behavior change;Breast Cancer Detection;Breast Cancer Early Detection;Breast Cancer Patient;Breast Cancer Risk Factor;breast cancer survival;cancer care;Caring;Clinic;Communities;community advisory board;community based participatory research;Continuity of Patient Care;COVID-19;COVID-19 pandemic;COVID-19 screening;culturally appropriate intervention;Data Collection;design;Diagnosis;Disease;Distant;Education;Educational Curriculum;efficacy evaluation;Eligibility Determination;Epidemiology;Ethnic Origin;evidence base;experience;Family;Focus Groups;Funding;Goals;Grant;Health;Healthy People 2020;improved;Individual;Intervention;Interview;Learning;learning community;Learning Module;Localized Disease;Malignant Breast Neoplasm;Mammography;mHealth;Morbidity - disease rate;mortality;Motivation;Names;Native American Research Center for Health;nutrition;obesity risk;Outpatients;patient navigator;peer;Physical activity;Population;Process;Provider;Race;Randomized;Readiness;Recording of previous events;Research;Resources;Rural Population;Schedule;screening;Stress;Survival Rate;System;Tablets;telephone coaching;Testing;Time;tool;Transportation;tribal community;tribal lands;tribal leader;uptake;Visit;Voice;White Mountain Apache;Woman;women's diagnosis;Women's Health;Women's study;Work

PROJECT_TITLE: Developing and evaluating scalable and culturally relevant interventions to improve breast cancer screening among White Mountain Apache women


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative This project will determine the cognitive and psychosocial impact of returning research results to healthy older adults that indicate 5-year risk of developing Alzheimer Disease. Understanding this will enable future Alzheimer research studies to be designed in a way that maintains scientific integrity while also respecting participant wishes to understand their risk of developing Alzheimer Disease.

PI_NAMEs: HARTZ, SARAH  (contact);MOZERSKY, JESSICA

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: African American;Age;Aging;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;arm;behavior change;Biological Markers;Brain;Clinical;Clinical Trials;Clinical Trials Design;Cognitive;cognitive change;cognitive testing;cohort;Communication;Consent;Data;Dementia;design;Development;Disease;Early intervention trials;Educational Materials;Enrollment;Ethics;Evaluation;Event;Foundations;Fright;Future;future implementation;Genetic;Genotype;Goals;health care service utilization;Healthcare;healthy aging;implementation science;Individual;Informed Consent;innovation;interest;Interview;Knowledge;Longitudinal cohort;Longitudinal Studies;Magnetic Resonance Imaging;Methodology;Methods;neuroimaging;older adult;Outcome;Participant;Patient Recruitments;Patients;Persons;Positron-Emission Tomography;pre-clinical;primary outcome;Process;psychosocial;psychosocial outcome;Race;racial difference;Randomized;randomized, clinical trials;Recommendation;Regrets;Reporting;Research;research study;Resources;Risk;Risk Adjustment;Scanning;secondary analysis;sex;Signs and Symptoms;Solid;success;Test Result;Testing;Thinking;Training Activity;trial enrollment;two-arm study;United States National Academy of Sciences;Universities;uptake;Washington

PROJECT_TITLE: Returning Research Results that Indicate Risk of Alzheimer Disease to Healthy Participants in Longitudinal Studies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-SEIR-B(80)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE MYODL122R mutated rhabdomyosarcoma (RMS) are a particularly aggressive pediatric muscle cancer that has an extremely poor prognosis, even despite multi-modal treatment with surgery, radiation, and chemotherapy. Here, we will identify the molecular programs underlying these aggressive RMS, including those that modulate cancer stem cell function, cell state, and therapy resistance. This work will define new pathways and therapeutic targets to kill MYOD1L122R mutant RMS that are likely shared across RMS subtypes.

PI_NAMEs: LANGENAU, DAVID MICHAEL (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Accounting;Affect;Aggressive behavior;Alleles;Animal Genetics;Animal Model;Antibodies;ATAC-seq;Automobile Driving;Binding;Binding Sites;Biological;Cancer Model;cancer stem cell;Cell model;Cell surface;cell type;Cells;Cessation of life;chemotherapy;Childhood;Childhood Soft Tissue Sarcoma;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Complex;Data;Development;Diagnosis;Disease;DNA Binding;Doxycycline;Drug Targeting;Exhibits;Genes;Genetic Engineering;Genetic Transcription;Goals;Grant;Growth;Heterogeneity;Human;In Vitro;innovation;Knock-in;Knock-out;Maintenance;malignant muscle neoplasm;Malignant Neoplasms;Modeling;Molecular;multiple omics;Mus;mutant;Mutate;Mutation;neoplastic cell;novel;Oncogenic;Operative Surgical Procedures;Outcome;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;PIK3CA gene;Production;Prognosis;programs;Proteins;Radiation therapy;refractory cancer;Relapse;Reporting;Resistance;Rhabdomyosarcoma;Role;single-cell RNA sequencing;Skeletal Muscle;Specificity;stem cell fate;stem cell function;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;transcription factor;translational impact;tumor;tumor growth;United States;Work;Xenograft procedure;Zebrafish

PROJECT_TITLE: Mechanisms of aggressive Rhabdomyosarcoma.

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness;Sleep Research;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Suicide in LGBTQ young adults has reached a crisis level, but our ability to predict and prevent suicide has not improved in 50 years. We will use brain imaging, actigraphy, and smartphone technology to measure critical social precipitants of suicidality and their interaction with general risk factors. With machine learning, a technique based on artificial intelligence, we will combine these sources of data to determine the way suicidal thoughts and behaviors develop over hours, days, and months.

PI_NAMEs: FORBES, ERIKA E (contact);SILK, JENNIFER S

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: actigraphy;Address;Adult;Affect;Affective;affective neuroscience;Age;Artificial Intelligence;Behavior;behavior change;brain based;brain circuitry;Brain imaging;Cellular Phone;Characteristics;Clinical;Communities;Computational Technique;Data;Data Analytics;Demographic Factors;Development;Distal;Distress;Ecological momentary assessment;Emergency Situation;emerging adult;Equilibrium;Event;Exclusion;experience;Face;family support;Feeling suicidal;follow-up;Frequencies;Functional Magnetic Resonance Imaging;functional MRI scan;Goals;health disparity;Hospitalization;Hotlines;Hour;Impulsive Behavior;Impulsivity;Individual Differences;Intervention;Interview;Lesbian Gay Bisexual Transgender Queer;Lesbian Gay Bisexual Transgender Queer Questioning;longitudinal design;Machine Learning;Measures;Mediator;Mental Health;minority stress;Modeling;modifiable risk;Moods;negative affect;neural;neuromechanism;Neurosciences;Pain;Participant;Population;Predictive Value;Prevention;Protocols documentation;Psychiatry;Recording of previous events;recruit;Recurrence;Regulation;Reporting;response;Risk Factors;Role;Safety;Same-sex;Self-Injurious Behavior;sensor;Shame;Sleep;Sleep disturbances;sleep quality;smartphone based assessment;social;Social Environment;social media;social model;social stigma;Source;Standardization;suicidal;suicidal behavior;Suicide;suicide model;Suicide prevention;suicide rate;Techniques;Technology;Testing;Text;Text Messaging;theories;Thinking;Time;trait;transgender;Victimization;Visit;young adult

PROJECT_TITLE: Social-Affective Vulnerability to Suicidality among LGBTQ Young Adults: Proximal and Distal Factors


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: TEMPE

ORG_DEPT: PHYSICS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: Project Narrative At the intracellular level, life's events unfold at spatiotemporal scales whose direct observation presents pro- found challenges to ﬂuorescence-based imaging and spectroscopic methods. To unravel life's events at the single molecule level, current methods exploit specialized hardware, long data acquisition periods, and other techniques thereby stressing sensitive samples with light and often compromising either spatial or temporal resolution altogether. Here, instead, we propose novel mathematical tools to resolve biological events with minimal spatiotemporal compromise often using orders of magnitude less data on our way toward capturing reaction-diffusion of single interacting molecules from just thousands of recorded photons.

PI_NAMEs: PRESSE, STEVE  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: adaptive optics;Antibiotics;Biological;Caenorhabditis elegans;Cell Nucleus;Chemistry;Collaborations;cost;Data;data acquisition;data exchange;detector;Deterioration;Diffusion;Disease;disease diagnostic;DNA;Energy Transfer;Escherichia coli;Event;Fluorescence;fluorescence imaging;Funding;Future;Image;in vivo;insight;Knowledge;Label;Learning;Life;Lifting;Light;Lighting;Maps;Mathematics;Methods;MicroRNAs;Modeling;Monitor;Morphologic artifacts;National Institute of General Medical Sciences;Nature;Nobel Prize;Noise;novel;Photons;Process;Property;Proteins;Publications;quantum;Reaction;Refractive Indices;Resolution;Sampling;single molecule;spatiotemporal;Spectrum Analysis;stoichiometry;Stress;Structure;Techniques;temporal measurement;Therapeutic Agents;tool;trafficking;transcription factor;Work

PROJECT_TITLE: Toward high spatiotemporal resolution models of single molecules for in vivo applications


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Skin Cancer

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative We identified a novel candidate driver of cutaneous squamous cell carcinoma (cSCC), a disease that disfigures one million and kills thousands of people annually. Preliminary results indicate that this candidate regulates the expression of extracellular matrix genes and DNA repair pathways, which are critical both for maintaining epidermal homeostasis and for cancer progression. This proposal will define the regulatory mechanism in normal epidermis and determine how mutation alters cSCC progression.

PI_NAMEs: DROLL, STEPHENIE  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Acceleration;Adherence;Adhesions;ATPase Domain;Binding;Biological Assay;Biological Markers;Biological Sciences;Biology;Biomedical Research;cancer genomics;Cancer Prognosis;Cancerous;carcinogenesis;career;Catalytic Domain;CDK4 gene;cell behavior;cell motility;Cell-Cell Adhesion;Cell-Matrix Junction;Cells;Chicago;ChIP-seq;Chromatin;Chromatin Remodeling Factor;cofactor;Communication;Core Facility;Data;Deposition;design;Development;Disease;DNA Binding;DNA Damage;DNA Repair;DNA Repair Pathway;ECM receptor;Educational workshop;epidermal stem cell;Epidermis;Epithelium;Equilibrium;experimental study;Extracellular Matrix;Focal Adhesions;Future;Gene Expression;Gene Expression Regulation;gene repair;gene repression;Genes;Genomic approach;genomic data;Genomics;Histone H2A;Homeostasis;Human;human tissue;indexing;Induced Mutation;insight;Integrins;Intercellular Junctions;Invaded;ITGA5 gene;keratinocyte;Kinetics;knock-down;Knowledge;LacZ Genes;Laminin;Length;Maintenance;Malignant Neoplasms;Mediating;Mentorship;Microscopy;migration;Modeling;Molecular;Motility;Mus;Mutate;Mutation;new therapeutic target;novel;Oncogenes;Operative Surgical Procedures;Pathway interactions;Persons;post-doctoral training;programs;Proliferating;protein protein interaction;Proteins;Proteomics;RAS genes;recruit;Research;Role;Scaffolding Protein;skills;Skin;Skin Cancer;Skin Carcinoma;skin squamous cell carcinoma;skin xenograft;small hairpin RNA;Squamous cell carcinoma;Supervision;Testing;therapeutic target;Thick;Tissue Model;Tissues;Training;transcriptome sequencing;tumor;tumor progression;Tumor Weights;United States;Universities;Up-Regulation;Variant;Western Blotting;Xenograft Model

PROJECT_TITLE: Characterizing the role of SRCAP in Epidermal Homeostasis and Squamous Cell Carcinoma


NIH_SPENDING_CATS: Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) is a progressive degenerative disease of the brain that results from a repeat expansion mutation that triggers production of a toxic protein. We will explore how this toxic protein is made, how its production contributes to FXTAS relevant symptoms in model systems and how we might block its production. Our long term goal is to leverage these findings to develop novel therapies for FXTAS patients and patients with other repeat expansions that cause neurodegeneration.

PI_NAMEs: TODD, PETER K (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: 5' Untranslated Regions;Address;Affect;age related;age related neurodegeneration;Biochemical;biochemical tools;biological adaptation to stress;Biological Models;Brain;Brain Diseases;Bypass;Cell Line;Cellular Stress;CGG repeat;CGG repeat expansion;Complex;Data;Degenerative Disorder;Disease;disease model;Drosophila genus;effective therapy;Event;Excision;Fragile X Gene;FXTAS;Genetic;Goals;Human;human induced pluripotent stem cells;Impairment;Induced pluripotent stem cell derived neurons;Inherited;Initiator Codon;Initiator tRNA;innovation;Intervention;Knock-out;Location;Mediating;Messenger RNA;Monitor;mouse model;Mus;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurons;novel;novel therapeutics;Nucleotides;Open Reading Frames;Pathogenesis;Pathogenicity;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Peptide Initiation Factors;Peptides;Persons;Phenotype;Phosphorylation;Play;prevent;Process;Production;protein aggregation;Protein Biosynthesis;Protein Kinase;Proteins;Reading Frames;Recycling;Reporter;response;Ribosomes;RNA;Role;Scanning;Series;stem cell model;Stress;stress granule;Symptoms;Techniques;Testing;Therapeutic;therapeutic target;Tissues;tool;Toxic effect;Translating;Translation Initiation;Translations;Ubiquitin;Viral;Virus Diseases

PROJECT_TITLE: CGG repeat associated translation in Fragile X-associated Tremor/Ataxia Syndrome


ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Atherosclerosis is an inflammatory/metabolic disease in which cells of the artery wall remodel to form a plaque that can narrow vessel lumens or rupture and block blood flow. This grant aims to understand the changes in endothelial cell fate that govern vessel remodeling and the pathways by which these changes promote disease. We will identify spatial and gene expression characteristics of susceptible EC subpopulations that mediate these transitions and elucidate the cellular positive feedback loops that mediate disease progression.

PI_NAMEs: SCHWARTZ, MARTIN A (contact);SIMONS, MICHAEL

PROGRAM_OFFICER_NAME: PLAYFORD, MARTIN P

PROJECT_TERMS: advanced disease;Appearance;Arterial Fatty Streak;Arteries;Atherosclerosis;Attention;Binding;Blood flow;Blood Vessels;Cell Proliferation;Cells;cerebral cavernous malformations;Characteristics;cytokine;Cytometry;Data;Deposition;Development;Disease;Disease Progression;Disease Resistance;Endothelial Cells;Endothelium;Event;Evolution;Extracellular Matrix;Feedback;Fibronectins;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Grant;Growth;Health;Heterogeneity;Human;human tissue;Image;immunocytochemistry;Inflammation;Inflammatory;Integrin alpha5beta1;Integrins;Leukocytes;Life Style;Link;Machine Learning;Macrophage;Maps;Mediating;Mesenchymal;Metabolic Diseases;Minor;Molecular;Molecular Profiling;mouse model;Mus;novel;Paint;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Phenotype;Population;Predisposition;Process;Production;programs;Proteomics;recruit;repaired;Resistance;response;Role;Rupture;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Smooth Muscle Myocytes;Stimulus;Techniques;Therapeutic;therapeutic target;therapy resistant;Time;tool;Transforming Growth Factor beta;Up-Regulation;vascular inflammation;Vascular Permeabilities;Work

PROJECT_TITLE: Endothelial-to-mesenchymal transition and atherosclerosis

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric - AIDS;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Despite recent advances in biomedical interventions that reduce the risk of HIV acquisition, worldwide an estimated 1.7 million people acquired HIV in 2018. Eliminating the pandemic will require a safe and effective HIV vaccine. Only through human clinical trials held to the highest scientific, ethical and regulatory standards will the goal of an HIV vaccine be realized.

PI_NAMEs: GILBERT, PETER B. (contact);HUANG, YUNDA ;JANES, HOLLY

PROGRAM_OFFICER_NAME: CALDER, THOMAS JAMES

PROJECT_TERMS: Address;Adherence;AIDS prevention;analysis pipeline;Antibody-mediated protection;antiretroviral therapy;Automobile Driving;Behavioral;Biological Assay;biomarker development;Biometry;Case/Control Studies;Clinical Data;Clinical Trials;Clinical Trials Network;clinically relevant;Collaborations;Computational Biology;cost efficient;Data;data acquisition;Data Analyses;data analysis pipeline;Data Coordinating Center;Data Element;data exchange;data management;design;Drug Kinetics;efficacy trial;Encapsulated;Engineering;Ensure;Epidemiology;Epitopes;Ethics;Evaluation;first-in-human;Futility;Genes;Genetic;Goals;Good Clinical Practice;high throughput analysis;HIV;HIV Infections;HIV vaccine;HIV Vaccine Trials Network;HIV-1;HIV-1 vaccine;HIV/AIDS;Human;Immune;immune function;Immune response;immunogenicity;Immunologics;Immunology;Incidence;Infant;Infection;Information Systems;Information Technology;Injectable;innovation;Intervention;Laboratories;Leadership;Licensure;Measures;Mediator;Methodology;Methods;Modality;Modeling;Modification;Monitor;Monoclonal Antibodies;National Institute of Allergy and Infectious Disease;neutralizing antibody;neutralizing monoclonal antibodies;Noise;novel;novel vaccines;operation;Oral;pandemic disease;pediatric human immunodeficiency virus;Persons;pharmacokinetic model;Phase;phase III trial;Phenotype;Population;Practice Management;pre-exposure prophylaxis;predictive modeling;prevent;Prevention;Procedures;programs;Protocols documentation;Qualifying;Quality Control;Regimen;Research;Research Activity;Research Design;Research Personnel;Resource-limited setting;Resources;response biomarker;Risk;Risk Assessment;Risk Behaviors;Risk Reduction;Safety;screening;Secure;Signal Transduction;Specific qualifier value;Standardization;Statistical Methods;Statistical Models;Surrogate Endpoint;System;Testing;Time;tool;trial design;Tuberculosis Vaccines;Underrepresented Minority;Vaccination;Vaccine Clinical Trial;Vaccine Design;vaccine efficacy;vaccine evaluation;vaccine immunogenicity;vaccine trial;vaccine-induced antibodies;Vaccines;vaccinology;Validation;Variant;Viremia;virology;Virus

PROJECT_TITLE: SDMC: HIV Vaccine Trials Network


NIH_SPENDING_CATS: Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Stem cells in the bone marrow produce all blood cells over the lifetime of an individual. We can, however, not maintain these cells in vitro, which would have major applications for the treatment of genetic and malignant blood diseases. The goal of this proposal is further study the specific cell biology of these cells and, using these findings, develop a novel strategy to maintain and expand blood stem cells in vitro.

PI_NAMEs: SNOECK, HANS-WILLEM E (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Alleles;Anemia;Apoptosis;Area;Attenuated;Biogenesis;Blood Cells;Bone Marrow;Bone Marrow Cells;Buffers;Calcium;Cell Compartmentation;Cell Maintenance;Cells;Cellular biology;Endowment;Environment;Epigenetic Process;epigenetic regulation;experimental study;Fetal Liver;Functional impairment;Funding;Genetic;Glycolysis;Goals;Guanosine Triphosphate Phosphohydrolases;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic stem cell expansion;hematopoietic stem cell quiescence;Hematopoietic stem cells;Hematopoietic System;In Vitro;Individual;Interferon alpha;Interferons;Lymphoid;Maintenance;Malignant - descriptor;Mediating;Membrane;Metabolism;microbiome;Mitochondria;mitochondrial metabolism;Molecular;Mus;mutant;Neonatal Mortality;novel strategies;nuclear factors of activated T-cells;OPA1 gene;Organelles;Perinatal mortality demographics;Phenotype;Play;Process;Production;progenitor;Publishing;reconstitution;Regulation;Respiration;response;Role;self-renewal;Signal Induction;Signal Transduction;Site;small molecule;STAT1 gene;stem cell biology;stem cells;Testing

PROJECT_TITLE: Mitochondrial Regulation of Hematopoietic Stem Cells

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Early exposure to research is a key component to increasing the number of physician-scientists. This research training fellowship proposal, that features highly engaged faculty and strong institutional support, will promote long-term medical student involvement in heart, lung, blood and sleep-related research. Participation in the fellowship is one of the first critical steps to the research distinction track and beyond, and it is cited by many medical school graduates as the basis for their decision to make research a part of their career.

PI_NAMEs: ROGHAIR, ROBERT D (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TITLE: Medical Student Summer Research Program


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: MINNEAPOLIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE: Osteonecrosis of the femoral head (ONFH) is a major cause of hip osteoarthritis and subsequent total joint replacement. Our research aims to improve clinical management and treatment of ONFH, and thereby reduce the overall burden of osteoarthritis, by advancing medical imaging techniques to enable earlier diagnosis of the disease and better prediction of clinical outcome to inform treatment decisions.

PI_NAMEs: JOHNSON, CASEY PETER (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Age;Animal Model;Animals;Apoptosis;Automobile Driving;bone;Bone necrosis;Cell Death;Child;chronic pain;Clinical;clinical imaging;Clinical Management;Clinical Treatment;Contralateral;Contrast Media;Degenerative polyarthritis;Detection;Diagnosis;Diffusion;Disease;disease diagnosis;Disease Progression;Early Diagnosis;Early treatment;efficacy evaluation;Evaluation;experimental study;Failure;Family suidae;femur head;Fibrosis;Gadolinium;Goals;Hip Joint;Hip Osteoarthritis;Hip region structure;hip replacement arthroplasty;Histologic;Image;imaging modality;Imaging Techniques;Implant;improved;improved outcome;in vivo;in vivo imaging;Injury;injury and repair;Intervention;Ischemia;ischemic injury;Joints;Legg-Perthes Disease;Lifelong disability;Magnetic Resonance Imaging;Maps;Marrow;Measures;Medical Imaging;Methods;Monitor;Motion;Necrosis;novel therapeutics;Operative Surgical Procedures;Osteogenesis;Outcome;Patient-Focused Outcomes;Patients;pediatric patients;Perfusion;perfusion imaging;Pilot Projects;porcine model;predict clinical outcome;preservation;prevent;radiological imaging;Regional Perfusion;Relaxation;repaired;Replacement Arthroplasty;Research;response;Risk;Second Look Surgery;Severities;Specimen;Study models;Surgical Decompression;Techniques;Therapeutic Intervention;Time;Total Hip Replacement;Translating;treatment response;Vascular blood supply;Work;young adult

PROJECT_TITLE: Early Detection and Monitoring of Osteonecrosis of the Femoral Head

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: DENTISTRY

PHR: NARRATIVE The identification of genetic factors that influence the size and shape of typical human facial features can provide important insights into the biological mechanisms that contribute to both normal and atypical facial development. The current proposal seeks to expand our knowledgebase by leveraging existing datasets to map genomic regions associated with human facial morphology, delineate functional variants at implicated loci with high-throughput experimental screening tools, and identify variants across the genome that impact clinically-relevant aspects of facial growth.

PI_NAMEs: CLAES, PETER ;SHAFFER, JOHN R;WEINBERG, SETH M (contact);WYSOCKA, JOANNA

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: 3-Dimensional;Address;Adolescence;Adolescent;African;Algorithms;Architecture;Automobile Driving;Biological;Biological Assay;Biology;Brain;candidate identification;cell type;Cephalic;Chromatin;chromatin immunoprecipitation;chromosome conformation capture;Chromosome Mapping;clinically relevant;cognitive development;cohort;Complex;Complex Genetic Trait;Congenital Abnormality;craniofacial;craniofacial structure;Data;data resource;Data Set;design;Development;Disease;Dysmorphology;embryo cell;Enhancers;Etiology;European;Experimental Designs;experimental study;Face;Funding;Future;Gene Expression;gene expression variation;Genes;Genetic;genetic analysis;genetic architecture;Genetic Enhancer Element;genetic linkage;Genetic Markers;Genetic Models;Genetic Polymorphism;genetic variant;Genetic Variation;Genome;Genome Scan;genome wide association study;genome-wide;Genomic Segment;Genomics;Genotype;Goals;Growth;Height;Heritability;Human;human embryonic stem cell;Image;image processing;improved;Individual;innovation;insight;Knowledge;knowledgebase;Lead;longitudinal dataset;Magnetic Resonance Imaging;Maps;Methods;Modeling;Molecular;Morphology;multi-ethnic;Nature;Neural Crest Cell;Normal Range;novel;Nucleic Acid Regulatory Sequences;Operative Surgical Procedures;Orthodontics;Outcome;Outcome Study;Pathway interactions;personalized medicine;personalized therapeutic;Phase;Phenotype;Population;promoter;rate of change;reconstruction;Reporter;Research Design;Sample Size;Sampling;Screening procedure;Series;shape analysis;Shapes;Signal Transduction;Sorting;Source;success;Surface;Syndrome;targeted treatment;Techniques;Technology;Testing;Therapeutic Intervention;trait;treatment planning;United States National Institutes of Health;Variant;variant detection;Weight

PROJECT_TITLE: The Genetic Architecture of Human Facial Morphology

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Aging;Genetics;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Structural plasticity of neurons in the brain can rewire circuits during development, in response to experiences, injury, diseases, and aging, and is crucial for brain function and health. Our knowledge of the genes and mechanisms regulating structural plasticity between development, adulthood, and in aging is limited, in part due to technical barriers in studying this complex process in mammalian brains. We propose use of a robust model of experience-dependent structural plasticity in C. elegans to identify conserved genes and molecular mechanisms that regulate structural plasticity across the lifespan, which will provide fundamental knowledge about this understudied form of plasticity and potentially uncover novel therapeutic targets.

PI_NAMEs: HART, MICHAEL P (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Adhesions;Adult;Age;age related decline;Aging;aging brain;Behavior;Behavioral;Behavioral Assay;Brain;brain health;Caenorhabditis elegans;Cell Adhesion;Cell Adhesion Molecules;Complex;CRISPR/Cas technology;Defect;Development;Disease;Down Syndrome Cell Adhesion Molecule;emerging adult;experience;experimental study;gene conservation;gene interaction;gene network;Genes;Genetic;Health;Hermaphroditism;Injury;insight;Knowledge;Learning;Life;life span;male;Measures;member;Modeling;Molecular;molecular targeted therapies;Morphology;Nematoda;Nervous System;Nervous System Disorder;Neurites;Neurodevelopmental Disorder;neuronal circuitry;Neuronal Plasticity;Neurons;neuropsychiatric disorder;new therapeutic target;novel;Output;Pathogenesis;Process;Protein Isoforms;Proteins;Regulation;Resolution;response;Role;scaffold;sex;Signal Transduction;Signaling Molecule;Structural Models;Synapses;Synaptic plasticity;System;Testing;Therapeutic Intervention;tool;transgene expression;Transgenic Organisms

PROJECT_TITLE: Genetic and molecular regulation of experience-dependent structural plasticity

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Genetics;Neurosciences;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Cerebellar injury is a frequent complication of pre-term birth and can lead to reduced cerebellar size and contribute to long-term neurodevelopmental problems, including in motor, cognitive, social and language development. We recently found that the newborn mouse cerebellum has remarkable regeneration potential, as it can recover from the loss of three cell types. Our model systems therefore represent a powerful system to uncover the cellular responses and molecular mechanism required during brain regeneration as a basis for developing strategies to enhance repair of cerebellar injuries.

PI_NAMEs: JOYNER, ALEXANDRA L. (contact)

PROJECT_TERMS: Address;age related;Astrocytes;autism spectrum disorder;Biological Models;Birth;Brain;Candidate Disease Gene;candidate identification;cell behavior;Cell Death;cell killing;Cell Nucleus;cell type;Cells;Cerebellar Cortex;Cerebellum;Clinical;Cognition;cognitive development;Complication;Computing Methodologies;Dedications;Development;Embryo;Environmental Risk Factor;Equilibrium;experimental study;functional gain;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;genetic approach;genetic signature;Genetic Transcription;Goals;granule cell;Growth;Human;Image;Immune;Injury;insight;Interneurons;irradiation;Label;Language;Language Development;Lobule;loss of function;Microglia;Modeling;Molecular;Motor;Motor Skills;Mus;mutant;Mutate;Natural regeneration;Neonatal;neonatal brain;nestin protein;Neurodevelopmental Problem;Neuroglia;Neurons;Newborn Infant;novel;Output;Paper;Pathway interactions;Performance;Perinatal;Population;postnatal;precursor cell;Premature Birth;Production;progenitor;Proliferating;Prosencephalon;Publishing;Purkinje Cells;Reactive Oxygen Species;Recovery;regeneration potential;Regenerative response;repaired;Resolution;response;response to injury;Risk Factors;Role;SHH gene;Signal Pathway;Signal Transduction;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Slice;Social Development;Social Functioning;Social Processes;stem;stem cell population;stem cell proliferation;stem cells;Stimulation of Cell Proliferation;System;Techniques;Testing;therapy development;Third Pregnancy Trimester;Time;Transgenic Mice;Validation;white matter;Work

PROJECT_TITLE: Signaling Pathways that Regulate Scaling and Regeneration of the Cerebellum

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Mental Health;Neurosciences;Stroke

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative Despite the importance of math skills in daily life tasks and the role of mathematics as a symbolic communication system, relatively little is known about the neural correlates of math or its interaction with language processing in the brain. The proposed research will explore this relationship by utilizing the lesion method and converging with a functional dataset, which will inform cognitive models of how numeracy abilities are organized in the brain and linked to language areas during both functional and disordered performance. This novel work investigating the neural correlates of numeracy through the lens of known language areas and pathways will shed light on math abilities, particularly as they relate to language, and will improve understanding of the consequences of related disorders, such as the frequently co-morbid aphasia and acalculia following stroke.

PI_NAMEs: DURICY, ERIN  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Address;Adult;angular gyrus;Anisotropy;Aphasia;Area;behavior test;Behavioral;Brain;Brain region;brain volume;Broca's area;career;career development;Code;Cognition;Cognitive;cognitive skill;Communication;Communication Research;comorbidity;Coupled;Data;Data Set;design;Diffusion Magnetic Resonance Imaging;diffusion weighted;Disease;Education;experience;Factor Analysis;Fiber;Foundations;Functional Magnetic Resonance Imaging;Future;Goals;grasp;gray matter;hemisphere damage;improved;Individual;Inferior frontal gyrus;interdisciplinary approach;interest;intraparietal sulcus;Knowledge;Language;Language Disorders;language processing;Left;lens;Lesion;Life;Link;Literature;Magnetic Resonance Imaging;Maps;mathematical ability;Mathematics;Measures;Mediation;Methodology;Methods;Modeling;multimodal neuroimaging;Necrosis;neural;neural correlate;Neurobiology;neuroimaging;Neuropsychology;novel;Pathway interactions;Performance;Play;Process;Reporting;Research;Research Personnel;Role;Sampling;Semantics;Severities;skills;Solid;Stroke;Structure;success;Symptoms;System;Techniques;theories;tractography;Variant;vector;verbal;Visual;white matter;Work

PROJECT_TITLE: Neural Basis of Math and Aphasia


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: NARRATIVE We will develop new types of fluorescent proteins, reporters and optogenetic tools for imaging, detection and light-regulation of molecular processes and interactions in mammalian cells, tissues and model animals. These probes will emit or be activated in the near-infrared spectral range where tissue transparency is the highest and will use the heme-derived compound biliverdin, naturally available in mammalian tissues, as the chromophore. The planned genetically encoded near-infrared optical probes will allow non-invasive visualization, sensing and light-control of the biochemistry and physiology of cells, organs and whole organisms in normal and pathological conditions, as well as spectral multiplexing with optical reagents of the visible range.

PI_NAMEs: VERKHUSHA, VLADISLAV  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: absorption;Animal Model;Animals;Antigens;Biliverdine;Biochemistry;cell growth regulation;Cell Physiology;Cells;chromophore;Complement;Detection;Development;Engineering;Enzymes;Exhibits;Fluorescent Probes;Gene Delivery;Heme;Imaging Device;imaging probe;improved;in vivo;in vivo imaging;Knowledge;Light;light scattering;Lighting;Mammalian Cell;Mammals;Metabolism;Molecular;nanobodies;Near-infrared optical imaging;non-invasive imaging;novel;Optics;optogenetics;Organ;Pathologic;Performance;Photochemistry;Photoreceptors;Physiology;Phytochrome;Process;protein function;Proteins;Reagent;receptor;Regulation;Reporter;Signal Induction;spatiotemporal;Technology;Tissues;tool;Visualization;Whole Organism

PROJECT_TITLE: Near-infrared fluorescent probes and optogenetic tools


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Cellular crosstalk is a process through a message transmitted between cells. Intercellular crosstalk of hepatocytes and non-parenchymal cells (i.e. Mφ and LSEC) is crucial for the maintenance of liver homeostasis. Under the pathological condition, hepatocyte damage results in the activation of fibrotic Mφ and LSEC. Thereby these cells play a critical role in the control of hepatic inflammation and the development of liver fibrosis. Exosomes are small membrane-bound extracellular vesicles and serve as natural carriers of signaling molecules such as cytokines for prompting cellular crosstalk. This project will identify a major cellular and molecular mechanism for the role of exosomes released from HCV-infected hepatocytes in promoting intercellular communication with non-parenchymal cells (i.e. Mφ and LSEC), leading to the development of liver fibrosis. The findings from our proposed research will provide a rationale basis of novel immunotherapeutic strategies that target molecules inducing pro-fibrotic factors through HCV-derived exosomes.

PI_NAMEs: HAHN, YOUNG S. (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Affect;Anti-Inflammatory Agents;Anti-viral Agents;Apoptotic;Automobile Driving;Binding;Biological Markers;Bypass;CASP3 gene;Cell Differentiation process;Cells;Chronic;Chronic Hepatitis C;chronic liver disease;Cirrhosis;Clinical;Coculture Techniques;cytokine;Data;design;Development;Disease Progression;end stage liver disease;Endothelial Cells;Equilibrium;exosome;extracellular vesicles;Fibrosis;Frequencies;Generations;Goals;Health;Hepatic;Hepatic Stellate Cell;Hepatitis C;Hepatitis C Therapy;Hepatitis C virus;Hepatocyte;Homeostasis;Human;humanized mouse;Immune;immunoregulation;Immunotherapeutic agent;In Vitro;in vivo;Inflammatory;Inflammatory Response;insight;intercellular communication;Life;Liver;liver development;Liver diseases;Liver Fibrosis;liver inflammation;Macrophage;Maintenance;Mediating;Membrane;MicroRNAs;Molecular;monocyte;mouse model;nanoparticle delivery;new therapeutic target;novel;novel therapeutic intervention;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;peripheral blood;Persons;Plasminogen Inactivators;Play;Population;Pre-Clinical Model;prevent;Prevention;Primary carcinoma of the liver cells;Principal Investigator;Process;Production;Profibrotic signal;programs;Regulation;Reporting;Research;Risk;Role;Severities;Signal Transduction;Signaling Molecule;stellate cell;Surface;Testing;Therapeutic;Therapeutic Agents;Transforming Growth Factor beta;transmission process;Virus;Work

PROJECT_TITLE: Role of HCV exosomes in intercellular communication

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-W(02)M]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Non-human primate (NHP) models of human genetic diseases provide valuable platforms for testing the safety and efficacy of novel strategies to prevent, delay, or reverse disease pathophysiology. Although numerous such models have been identified, multiple challenges, including the long-term availability of carriers with particular mutations, threaten both the propagation and availability of these models to investigators. The goal of this project is to develop a National embryos, to NHP Model Embryo Resource (NNMER) to help investigators cryopreserve gametes, and fibroblasts from NHP models of human disease and which will provide investigators with access these valuable disease models for studies of disease pathogenesis and to test the safety and efficacy of novel therapies.

PI_NAMEs: HANNA, CAROL BAILEY MCCORMICK;SHERMAN, LARRY S. (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Affect;Age;Aging;Animal Model;Animals;Assisted Reproductive Technology;autosome;Behavioral;blastocyst;Breeding;cancer predisposition;Clinical;cognitive capacity;Collection;Cryopreservation;Dermatologic;Development;Disease;disease model;Disease Progression;Embryo;embryo cryopreservation;Ensure;Female;Fertilization in Vitro;Fibroblasts;Foundations;Functional disorder;Generations;Genes;Genetic;Genetic Carriers;Genetic Diseases;Genetic Models;Genetic Research;Genome;Genomics;Genotype;Germ Cells;Goals;Human;human disease;Human Genetics;human model;Human Resources;Immunologics;Inherited;interest;Laboratories;Macaca;Macaca mulatta;male;Modeling;Molecular;Mus;Mutation;Neuroanatomy;Neurologic;nonhuman primate;novel;novel strategies;novel therapeutic intervention;novel therapeutics;offspring;Oregon;outreach;Pathogenesis;Patients;Phenotype;Pre-Clinical Model;pre-clinical research;precision medicine;preclinical development;preclinical study;Preclinical Testing;preservation;prevent;Primate Diseases;Primates;prospective;Protocols documentation;Publications;Rain;rare variant;reproductive;Research;research and development;Research Personnel;Resources;Rodent;Rodent Model;Safety;safety assessment;safety testing;Study models;symposium;Testing;Therapeutic;therapeutic development;tool;Training;Vaccine Research;Variant;web site

PROJECT_TITLE: A National NHP Embryo Resource of Human Genetic Disease Models


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Genetics;Human Genome;Lung;Pediatric;Social Determinants of Health

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative  This project will investigate the relationship between psychosocial experiences and health in children affected by asthma and their asymptomatic siblings. The goal is to dissect the role of different cell types, disease status versus psychosocial environment, and genetic variation in transcriptional dysregulation observed in children with asthma living in risky family environments.

PI_NAMEs: LUCA, FRANCESCA ;PIQUE-REGI, ROGER  (contact);ZILIOLI, SAMUELE

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Affect;African ancestry;Americas;Asthma;asthmatic;Behavior Therapy;Biological;Blood;Blood Cells;cell type;Cells;Cellular Immunity;Child;Child Health;Childhood;Chronic Disease;cohort;Collecting Cell;Complex;Data;design;Diagnosis;Disease;Emotional;Environment;Environmental Risk Factor;experience;Family;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic association;Genetic Transcription;genetic variant;Genetic Variation;genome-wide;Genotype;Glucocorticoids;Goals;Health;Hospitalization;Human;Hydrocortisone;Immune;immune function;immune health;Immunomodulators;Individual;Industrialization;Infection;Inflammatory;inter-individual variation;Leukocytes;Libraries;Maps;Measures;Mediating;Mediator;Medical;metropolitan;Mitogens;Molecular;Outcome;Pathway interactions;Pattern;Peripheral;Peripheral Blood Mononuclear Cell;Personal Satisfaction;Phenotype;physical conditioning;Population;Process;psychosocial;Psychosocial Factor;psychosocial resources;psychosocial stressors;pulmonary function;recruit;Resistance;response;Risk;Role;Sampling;Self Disclosure;Severities;Severity of illness;Siblings;single cell analysis;single-cell RNA sequencing;social relationships;Stimulus;Symptoms;trait;Transcriptional Regulation;transcriptome;transcriptome sequencing;Treatment/Psychosocial Effects;Youth

PROJECT_TITLE: Psychosocial and Genetic Effects on Gene Expression and Asthma

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Most patients diagnosed with acute myeloid leukemia (AML), a lethal blood and bone marrow cancer, must face disease recurrence (or relapse), which emerges due to development of chemoresistance. This proposal seeks to leverage drugs that target the anti-apoptotic pathway using functional biological tools to prevent and treat relapse. This work will provide a deeper understanding of pathways that are essential to the development of chemoresistance and reveal novel therapeutic opportunities.

PI_NAMEs: GARCIA, JACQUELINE SUEN (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Academic support;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Allogenic;Apoptosis;Apoptotic;Area;BCL1 Oncogene;BH3 Domain;BH3 peptide;Biological;Biological Assay;Biology;Blood;Busulfan;career;career development;Cells;Chemoresistance;Chemosensitization;chemotherapy;Clinical;Clinical Investigator;Clinical Research;clinical training;clinical translation;Clinical Trials;Combined Modality Therapy;conditioning;cytochrome c;Dana-Farber Cancer Institute;Data;Dependence;design;Development;Diagnosis;Dose;Drug Combinations;Drug Exposure;Drug Targeting;Elderly Acute Myeloblastic Leukemia;Face;Funding;Gene Family;Goals;Hematopoietic Stem Cell Transplantation;high risk;Human;improved;in vivo;Individual;inhibitor;instructor;interest;International;Investigation;kinase inhibitor;Laboratories;lenalidomide;leukemia;leukemia relapse;leukemia treatment;Malignant Bone Marrow Neoplasm;MCL1 gene;Measures;Mediator;medical schools;Medicine;Mentors;Mentorship;mimetics;Mitochondria;Mutation;myeloblast;novel;novel drug combination;novel strategies;novel therapeutic intervention;novel therapeutics;older patient;Pathway interactions;patient derived xenograft model;patient oriented;Patients;Peptides;Pharmaceutical Preparations;pilot trial;precision drugs;prevent;Program Development;Protein Family;Qualifying;Readiness;Recurrent disease;Regimen;Relapse;relapse risk;Research;Research Methodology;Research Personnel;Research Project Grants;Resistance;Resources;response;Risk;Role;Safety;Sampling;skills;sound;Therapeutic;therapeutic target;Time;tool;Training;Translational Research;translational scientist;Transplant Recipients;Transplantation;Treatment Failure;Treatment outcome;Work

PROJECT_TITLE: Enhancing Venetoclax Activity in Chemoresistant Acute Myeloid Leukemia

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: DURANGO

ORG_DEPT: BIOLOGY

ORG_NAME: FORT LEWIS COLLEGE

ORG_STATE: CO

PHR: PROJECT NARRATIVE Diversity in science and research is important in meeting the health needs of the nation. The long-term goal of this proposal is to maintain a sustainable biomedical and behavioral research training program that will more than double the number of underrepresented (UR) students graduating with a STEM (Science, Technology, Engineering and Math) degree and pursuing a Ph.D. in biomedical or behavioral research. This goal will be achieved by providing UR students an increased awareness of graduate research, by better preparing UR students to enter Ph.D. granting programs, and by graduating and enrolling more UR students in Ph.D. granting programs.

PI_NAMEs: MILLER, KENNETH AARON (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: African American population;Behavioral Research;Behavioral Sciences;Biochemistry;Biology;Biomedical Research;biomedical scientist;career;Chemistry;cohort;college;Development;Doctor of Philosophy;Educational workshop;Eligibility Determination;Engineering;Enrollment;experience;Extramural Activities;faculty mentor;financial literacy;Fostering;Foundations;Funding;Goals;graduate school;graduate school preparation;Health Sciences;Hispanic;Hispanic Populations;Institution;matriculation;Native Hawaiian or Other Pacific Islander;oral communication;Physics;Population;Positioning Attribute;Preparation;programs;Psychology;Reproducibility;Research;Research Training;responsible research conduct;skills;social;Student Selections;Students;success;summer research;Training;Training Programs;undergraduate student;underrepresented minority student;Underrepresented Students;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: U-RISE at Fort Lewis College

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE Studies of reinforcement learning over the past two decades have shown that the brain possesses multiple decision systems, including an inferential or “model-based” system that utilizes an internal model for planning, and a retrospective or “model-free” system that repeats reinforced actions. This proposal seeks to determine the connectivity patterns and dynamics of local and long-range synaptic inputs that arbitrate between these decision- making systems. A greater mechanistic understanding of arbitration holds promise for developing novel therapies for disorders in which arbitration is thought to go awry, such as obsessive-compulsive disorder, which is thought to reflect a predominance of the model-free system.

PI_NAMEs: DEMAEGD, MARGARET LOUISE (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;Anatomy;Animals;Arbitration;Behavior;Behavior monitoring;Behavioral Model;behavioral study;Brain;cell type;Chronic;cognitive task;Computing Methodologies;Confocal Microscopy;Corpus striatum structure;Data;Decision Making;Disease;Dorsal;Electrophysiology (science);Environment;Excitatory Postsynaptic Potentials;Exhibits;experience;flexibility;free behavior;Future;Genetic;Goals;Human;Implant;In Vitro;in vivo;Injections;Interneurons;Knowledge;Lateral;Lead;Learning;Logic;Measures;Medial;Mediating;Methods;Microelectrodes;microscopic imaging;Modeling;neural;neural circuit;Neurons;novel;novel therapeutics;Obsessive-Compulsive Disorder;optogenetics;Pattern;Population;Prefrontal Cortex;Process;Psyche structure;Psychological reinforcement;Rattus;Reporting;response;simulation;statistics;Structure;Synapses;System;Techniques;Testing;Theoretical Studies;Tracer;Uncertainty;Viral;Visual;Whole-Cell Recordings;Work

PROJECT_TITLE: Circuit mechanisms of arbitration between distinct reinforcement learning systems


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Public Health Relevance Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes affected individuals to tumors of the nervous system, and other disease manifestations. To identify how tumors form we are using mouse models and modern methodologies to study tumour-immune interactions. These state-of-the art interdisciplinary approaches allow us to study the role of NF1, early stages of tumorigenesis and to identify points for tumour prevention and therapeutic intervention.

PI_NAMEs: RATNER, NANCY  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Adoptive Transfer;Affect;Alleles;Animal Model;Animals;Antibodies;Antigen Presentation;Antigen-Presenting Cells;B-Lymphocytes;Back;Benign;CD8-Positive T-Lymphocytes;cell dedifferentiation;Cell Line;Cell model;cell type;Cells;Characteristics;chemokine;CXCL10 gene;CXCL9 gene;CXCR3 gene;cytokine;Data;Dendritic Cells;Development;disabled;Disease;Fibroblasts;G Protein-Coupled Receptor Signaling;Gene Expression;Genetic Diseases;Hereditary Disease;Immune;In Vitro;Individual;interdisciplinary approach;Interferon Type I;Interferon Type II;Interferons;knockout gene;Link;Macrophage;Maintenance;Methodology;Modernization;mouse model;Mus;neoplastic cell;Nervous System Neoplasms;neurofibroma;Neurofibromatoses;Neurofibromatosis 1;NF1 gene;NF1 mutation;Pathway interactions;Patients;Peripheral Nervous System;Peripheral Nervous System Neoplasms;precursor cell;preventive intervention;Production;public health relevance;Rag1 Mouse;receptor;Recording of previous events;recruit;response;RNA;Role;Schwann Cells;self-renewal;Signal Transduction;single-cell RNA sequencing;Spleen;STAT3 gene;System;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic Intervention;therapeutic target;transcriptome;transcriptomics;tumor;Tumor Antigens;tumor initiation;tumor specificity;tumorigenesis

PROJECT_TITLE: Mitogenic Activities in Neurofibromatosis

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]