ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: Projective Narrative The rising prevalence of obesity within our Veteran and non-Veteran population leads many people to weight cycle, dramatically altering the adipose tissue immune environment and increasing inflammation. The immune system within adipose tissue develops an obesogenic memory to weight cycling, potentiating poor metabolic outcomes. Our goal is to identify mechanisms of immune memory to better define the pathogenesis of obesity associated metabolic disorders. Specifically, we will study the surface protein, CD70, an adaptor protein essential for T cell memory formation. Using gene knockout and antibody studies, we will determine how loss of T cell memory formation during weight gain and weight loss impacts adipose tissue inflammation and metabolic outcomes.

PI_NAMEs: HASTY, ALYSSA H (contact)

PROJECT_TERMS: Adaptive Immune System;Adaptor Signaling Protein;Address;Adipocytes;Adipose tissue;Affect;Animals;Antibodies;Antibody-mediated protection;Antigen-Presenting Cells;Antigens;Area;Attenuated;Award;Binding;Body Weight;Body Weight decreased;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;career;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death;Cell Separation;Cell Surface Proteins;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chronic;Clonal Expansion;combat;Data;Dedications;Defect;dietary;Disease;effector T cell;Environment;exhaustion;Food;Funding;Genomic DNA;genomic platform;glucose tolerance;Goals;Granzyme;Health Personnel;Human;Immune;Immune system;Immunologic Memory;Immunologics;Immunotherapeutic agent;Impairment;improved;Individual;Inflammation;Inflammatory;Inflammatory Response;Innate Immune System;knockout gene;Knockout Mice;Laboratories;Life;Life Style Modification;Ligands;Mediating;member;Membrane Proteins;Memory;Mentors;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Modeling;mouse model;Mus;Obese Mice;obese person;Obesity;obesogenic;Outcome;Parents;Pathogenesis;Patients;Persons;Phase;Play;Population;Prevalence;prevent;Prevention;Publishing;receptor;Receptor Signaling;recruit;Reporting;Research;Risk;Role;sedentary lifestyle;senescence;single cell sequencing;single-cell RNA sequencing;Stimulus;T cell clonality;T memory cell;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Therapeutic;Time;Training;Veterans;Virus;Weight;Weight Gain;Wild Type Mouse;Work

PROJECT_TITLE: Immunological Memory of Obesity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 DEIR-W (01)]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Pediatric;Prevention;Rare Diseases

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PUBLIC HEALTH RELEVANCE STATEMENT The tau protein is widely expressed in brain cells and is critical to brain function. In humans, a mutation in the gene encoding for tau (MAPT R406W) changes the protein and makes it easier for tau to abnormally accumulate, ultimately causing frontotemporal dementia (FTD). This proposal aims to study when FTD starts by studying biomarkers of FTD in a family of rhesus monkeys carrying an exact replicate of the human MAPT R406W FTD-related mutation. This project has the potential to aid patients, because to know when FTD starts will help define when to begin future treatments to prevent the disease.

PI_NAMEs: EMBORG, MARINA  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Adolescent;Adult;Age;animal old age;Animals;Atrophic;Autopsy;autosome;Award;behavior test;Behavioral;Binding;Biological Assay;Biological Markers;Blood;Brain;brain cell;Brain region;Child;Clinical;Clinical Research;clinical translation;Cognitive;Data;Data Set;Databases;Dementia;design;Development;Diagnosis;Disease;dominant genetic mutation;Early identification;Evaluation;Family;Filament;flexibility;Frontotemporal Dementia;Future;Genes;Genetic;Genetic Counseling;Genetic Diseases;genetic predictors;Genetic Screening;Genetic study;genetic testing;Glial Fibrillary Acidic Protein;Gliosis;Goals;gray matter;Human;human data;Image;Infant;Inherited;Interleukin-6;Language Disorders;Learning;Letters;Life;life span;Light;Link;Liquid substance;Macaca mulatta;Magnetic Resonance Imaging;MAPT gene;Measures;Memory Loss;metabolomics;Minor;Monkeys;Moods;Motor;motor behavior;MRI Scans;Mutation;mutation carrier;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;neuroprotection;nonhuman primate;offspring;older adult;Parkinsonian Disorders;Pathologic Processes;patient screening;Patients;Personality;Phenotype;Point Mutation;Positron-Emission Tomography;preclinical study;predictive test;prevent;Primates;Protein Isoforms;Proteins;Proteomics;public health relevance;Recommendation;Research;Resources;response;Rhesus;Sequence Homology;sex;Sexual Maturation;Stress;Symptoms;tau mutation;tau Proteins;tau-1;Tauopathies;Testing;timeline;white matter;Wisconsin;young adult

PROJECT_TITLE: Frontotemporal dementia in rhesus macaques

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Huntington

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MARSHALL UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE In 2022, fentanyl overdose was the leading cause of death for US adults aged 18 - 45. This striking statistic underscores the urgent need to discover and characterize the genetic causes of fentanyl addiction, a highly heritable disease. The successful completion of this project, in which we will use genetically diverse mice to better understand the genes that cause individuals to abuse fentanyl, will contribute to the development of novel, more effective addiction treatments.

PI_NAMEs: DICKSON, PRICE EVANS (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: addiction;Adult;aged;Alleles;Anatomy;approach behavior;Automobile Driving;Awareness;Behavior;behavior test;Bioinformatics;Biological Assay;Brain;Cause of Death;cell type;Cells;Cocaine Dependence;cocaine self-administration;Communities;Data;Development;differential expression;Disease;Dose;drug craving;Drug usage;Electrophysiology (science);Exhibits;experience;experimental study;Exposure to;Extinction;Female;Fentanyl;fentanyl abuse;fentanyl overdose;fentanyl self-administration;Foundations;Future;Genes;Genetic;genetic analysis;genetic approach;genetic resource;Genomics;Goals;Heritability;Human;Inbred Mouse;Incentives;Individual;Intravenous;Laboratories;male;Maps;mid-career faculty;Motivation;mouse genetics;Mus;neurophysiology;next generation sequencing;novel;Nucleus Accumbens;Operant Conditioning;paired stimuli;patch clamp;Pathologic;Pharmaceutical Preparations;pharmacologic;Phenotype;Price;professor;Protein Isoforms;Public Health;Quantitative Trait Loci;Recombinants;Relapse;Resistance;Resources;response;Rewards;Risk Assessment;Role;Scanning;Self Administration;single nucleus RNA-sequencing;statistics;Stimulus;System;Techniques;theories;Time;transcriptome sequencing;transcriptomics;Universities;vector;Work

PROJECT_TITLE: Dissecting the shared genetic mechanisms driving fentanyl addiction, cocaine addiction, and incentive sensitization using the Collaborative Cross mouse panel

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Hypertension;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PITTSBURGH

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Traumatic brain injuries (TBIs) are heterogeneous and affect approximately 69 million persons annually worldwide, causing debilitating and enduring complex cognitive and psychosocial impairments regardless of injury location, yet the preclinical research to date has largely overlooked attention and emotional deficits post- TBI, which may be exacerbated by the presence of clinical comorbidities. The overarching aim of this R21 proposal is to remedy the paucity of studies examining comorbidities during the TBI recovery phase, by exploring how adult-onset hypertension (i.e., high blood pressure), a common underlying condition for approximately 50% of the adult United States population, may impact long-term motor, complex cognitive, and anxiety-like alterations subsequent to pediatric or adult injuries. The findings from the proposed preclinical studies, carried out in both male and female rats, will advance our understanding of neurobehavioral and histopathological alterations in survivors of brain trauma living with comorbid hypertension, as well as facilitate identifying mechanisms through which therapeutic and rehabilitative approaches may be targeted to relevant symptoms in the clinic.

PI_NAMEs: BONDI, CORINA OANA (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: 14 year old;Adult;Adult women;Affect;Age;American Heart Association;Animal Model;Anxiety;Area;Arteries;Astrocytes;Attention;Behavior assessment;Behavioral Assay;bench to bedside;Blood flow;Brain region;Cardiovascular Diseases;Cessation of life;Childhood;Childhood Injury;Chronic;Clinic;Clinical;clinically relevant;Cognitive;comorbidity;Complex;Contralateral;controlled cortical impact;Corpus striatum structure;decubitus ulcer;design;Development;Diagnosis;disability;Emergency department visit;Emotional;Equilibrium;Exhibits;experimental study;Female;flexibility;Funding;Future;Glial Fibrillary Acidic Protein;Heart Rate;Hippocampus;Histologic;Human;Hypertension;hypertensive;Immunohistochemistry;Impaired cognition;Impairment;Impulsivity;Inbred SHR Rats;Inbred WKY Rats;injured;Injury;Ipsilateral;Knowledge;Learning;Lesion;Location;male;Medical;Menstrual cycle;Modality;Motor;Muscle;Myocardial Infarction;neurobehavioral;Neurocognitive;neuroinflammation;Neurologic;neuronal survival;normotensive;novel;Outcome;Parietal;Patients;Persons;Phase;Phenotype;Physiological;Population;pre-clinical;Pre-Clinical Model;pre-clinical research;preclinical study;premature;psychosocial;Quality of life;Rattus;Reaction Time;Rehabilitation therapy;Research;Research Project Grants;response;Rotarod Performance Test;Schools;Severities;Sex Differences;Shock;Stroke;Survivors;sustained attention;Symptoms;Testing;Thalamic structure;Therapeutic;Time;Tissues;Traumatic Brain Injury;Traumatic Brain Injury recovery;United States;United States Department of Veterans Affairs;United States National Institutes of Health;Walking;Woman;young adult

PROJECT_TITLE: Neurobehavioral and pathophysiological effects of traumatic brain injury in spontaneously hypertensive rats

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Obesity is among the most pressing and costly medical challenges confronting modern society. While neurons that express agouti-related protein (AgRP) are implicated in the regulation of energy balance, our recent work suggests there are distinct subsets of AgRP neurons that mediate different metabolic and behavioral functions. The identification and characterization of distinct subsets of AgRP neurons, and mapping their downstream projections will advance our understanding of energy homeostasis and has the potential to identify novel therapeutic strategies for obesity.

PI_NAMEs: MORTON, GREGORY J (contact);PERS, TUNE HANNES

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Acute;Anatomy;ART protein;Behavioral;behavioral response;Bioinformatics;Biological;Biological Process;blood glucose regulation;Brain;Brain region;Cells;Closure by clamp;Computational Technique;CRISPR/Cas technology;Cues;Data;Development;Diabetes Mellitus;Disease;energy balance;Energy Intake;Energy Metabolism;Exhibits;experience;Fasting;feeding;FOS gene;Future;gain of function;Genetic;Genetic Transcription;ghrelin;Glucose;Goals;Growth;Health;Heterogeneity;Homeostasis;Hormonal;Hyperglycemia;Hyperphagia;Hypothalamic structure;Injections;Intake;intraperitoneal;Knowledge;Laboratories;Leptin;Leptin deficiency;leptin receptor;Maps;Mediating;Medical Care Costs;Metabolic;Metabolism;Modernization;Molecular;motivated behavior;mouse genetics;multidisciplinary;Mus;neural;Neurons;novel;novel strategies;novel therapeutic intervention;Nutrient;Obesity;obesity treatment;Pathogenesis;Physiological;Play;Population;Population Heterogeneity;Regulation;Reproduction;Resources;response;Rewards;Role;segregation;Sensory;Signal Transduction;single-cell RNA sequencing;skills;Social Behavior;Societies;Stains;Stimulus;Structure of nucleus infundibularis hypothalami;success;synergism;Techniques;Temperature;Thermogenesis;transcriptome;transcriptomics;Universities;unpublished works;Viral;Work

PROJECT_TITLE: Identifying and characterizing molecular and circuitry-based heterogeneity of AgRP neurons.

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Clinical Research;Cystic Fibrosis;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Rare Diseases;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE While our knowledge of the effects of climate change on human health is expanding, including evidence that transient changes in local ambient temperatures can lead to acute exacerbations of asthma and COPD, the effects of temperature change on long term respiratory outcomes are unknown. The goal of this proposal is to identify relationships between temperature changes and longitudinal lung function using a cystic fibrosis model. This valuable information will provide additional insight and predictions for the effects of climate change on human health.

PI_NAMEs: COLLACO, JOSEPH MICHAEL (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Accreditation;Acute;Address;Affect;Age;Air;Air Pollution;Area;Asthma;asthma exacerbation;Australia;burden of illness;Caring;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Climate;climate change;Clinical;cohort;Cohort Studies;Complex;Cross-Sectional Studies;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;data integration;Disparity population;Environmental Risk Factor;environmental tobacco smoke;Ethnic Origin;experience;falls;Foundations;Future;General Population;Genetic;Goals;Health;health data;Heart Diseases;Hematological Disease;Household;Human;Income;Individual;insight;Knowledge;life span;Location;Longitudinal Studies;Lung;Lung Diseases;lung health;Maps;Measures;Mediating;Mediation;Methods;Modeling;mortality;National Health and Nutrition Examination Survey;National Heart, Lung, and Blood Institute;Natural experiment;Outcome;patient registry;Persons;Population;Predisposition;Prevalence;Pulmonary Cystic Fibrosis;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Qualifying;Race;Research;research study;Resolution;respiratory;respiratory morbidity;respiratory pathogen;Role;Seasons;Sleep Disorders;social epidemiology;social health determinants;Socioeconomic Factors;socioeconomics;Techniques;Temperature;Testing;Time;trait;United States;Weather

PROJECT_TITLE: Climate Change and Longitudinal Lung Function

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: Project Narrative Allogeneic hematopoietic cell transplantation (Allo-HCT) is a curative therapy for hematological malignancies, but graft versus host disease (GVHD), especially chronic GVHD, remains the major cause of morbidity and mortality of long-term survivors. The proposed studies will unravel the pathogenesis of chronic GVHD and develop new approach for preventing and treating chronic GVHD.

PI_NAMEs: ZENG, DEFU  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Allogenic;Antibodies;Autoantibodies;Autoimmune;autoreactivity;B-Lymphocytes;Biological;Blood;CD19 gene;CD4 Positive T Lymphocytes;Cell Communication;Cells;chemokine;chronic graft versus host disease;Chronic Phase;curative treatments;Cutaneous;CXCL13 gene;cytokine;cytotoxic;cytotoxicity;Dendritic Cells;Development;Disease;Fibroblasts;Fibrosis;Frequencies;graft vs host disease;graft vs leukemia effect;Granulocyte-Macrophage Colony-Stimulating Factor;Granzyme;Guide RNA;Helper-Inducer T-Lymphocyte;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Human;IgG autoantibodies;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;Infiltration;Interferons;Interleukin-13;interleukin-21;leukemia/lymphoma;Liver;Long-Term Survivors;Lung;Lymphocyte;Lymphoid Tissue;Lymphopenia;Macrophage;Measures;Mediating;Memory;Memory B-Lymphocyte;memory CD4 T lymphocyte;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;novel;novel strategies;Organ;Pathogenesis;Pathogenicity;Pathway interactions;Patients;PD-1/PD-L1;Penetration;Peripheral;Plasmablast;Play;preservation;prevent;Prevention;Production;progenitor;Receptor Signaling;Regulation;Role;Signal Transduction;Skin;Skin graft;STAT3 gene;stem;stem cells;stemness;Syndrome;T-Lymphocyte;tertiary lymphoid organ;Testing;Tissue Differentiation;Tissues;TNF gene

PROJECT_TITLE: Role of autoreactivity in pathogenesis of chronic graft versus host disease

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: ES

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Diabetes;Digestive Diseases;Endocrine Disruptors;Health Effects of Indoor Air Pollution;Microbiome;Nutrition;Obesity;Prevention

PHR: PROJECT NARRATIVES Diabetes is a complex disease is caused by an interaction among genetic, behavioral, and environmental factors. The legacy flame retardants polybrominated diphenyl ethers (PBDEs) and the current-use flame retardant alternative tetrabromobisphenol A TBBPA (sometimes called “regrettable substitute”) are linked to diabetes in humans and animal models. The proposed study will use genetically modified mouse models to mechanistically investigate how early life flame retardant exposure mediated dysbiosis in the gut microbiome modulates host nuclear receptor signaling and contributes to delayed onset of diabetes phenotype in adulthood, especially following exposure to a secondary risk factor later in life such as a western diet.

PI_NAMEs: CUI, JULIA YUE  (contact);GU, HAIWEI ;MANI, SRIDHAR

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Adult;adult obesity;Animal Model;Animals;Anti-diabetic Drugs;Anti-Inflammatory Agents;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Behavioral;cell type;Cells;Chemicals;ChIP-seq;Complex;constitutive androstane receptor;CYP3A4 gene;Cytochrome P450;Development;Diabetes Mellitus;diabetic;Diet;diet-induced obesity;Dietary Factors;Disease;dysbiosis;early life exposure;Economic Burden;Effectiveness;Endocrine;Endocrine disruption;Environmental Risk Factor;Epidemiology;Exposure to;fecal transplantation;Flame Retardants;Gene Expression;Gene Modified;Genes;Genetic;Genotype;Germ-Free;Grant;gut dysbiosis;gut inflammation;gut microbiome;gut microbiota;gut-liver axis;Hepatic;Hepatocyte;High Fat Diet;high risk;hormone metabolism;Human;human model;Immune;Indoles;Industrialization;Inflammation;Inflammatory;inflammatory marker;Intervention;Intestinal Content;Intestines;Isotopes;Leaky Gut;lens;Life;Link;Liver;liver injury;Mediating;Mediator;Metabolism;metabolomics;Metagenomics;Microbe;microbial;microbial signature;microbiome;mimicry;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear Receptors;Obesity;obesogenic;offspring;Oral;Organ;Outcome;Pancreas;pandemic disease;Pathogenesis;Phenotype;Physiological;polybrominated diphenyl ether;postnatal;Pregnancy;pregnane X receptor;Prevalence;prevent;Propionic Acids;pup;receptor;Receptor Activation;Receptor Signaling;remediation;Research;response;Risk Factors;Role;Sampling;Serum;Shotgun Sequencing;Signal Transduction;social;species difference;Testing;tetrabromobisphenol A;Thyroid Hormones;Time;transcriptomics;Transgenic Mice;Tryptophan;Tryptophan Metabolism Pathway;United States;Volatile Fatty Acids;Weaning;western diet

PROJECT_TITLE: Developmental flame retardant exposure, gut microbiome, and obesity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (03)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Genetics;Human Genome;Prevention;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Alcohol use disorder (AUD) and related problems kill over 3 million people each year and account for up to 6% of global deaths. We propose to perform genome-wide association studies and use high throughput reporter assays to identify variants and genes related to alcohol sensitivity and tolerance, two key risk factors for AUD; then replicate and validate our findings using diversity outbred mice and gene expression analysis. These results will advance our knowledge of the etiologies of alcohol related problems and facilitate the development of novel treatment and prevention strategies.

PI_NAMEs: LAI, DONGBING  (contact);LIU, YUNLONG ;PARKER, CLARISSA C

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: African ancestry;Alcohol consumption;alcohol effect;alcohol related gene;alcohol related problem;alcohol sensitivity;alcohol use disorder;Alcohols;Architecture;Ataxia;Biological;Biological Assay;Brain;brain cell;Brain region;brain tissue;Categories;causal variant;Cell Line;cell type;Cells;Cessation of life;Chronic;cost effective;Data;Databases;Development;Diagnosis;Diagnostic;Disease;DSM-IV;endophenotype;Ethanol Metabolism;Etiology;European ancestry;Face;Family;Gene Expression;Gene Expression Profiling;gene network;Genes;Genetic;genetic analysis;genetic architecture;Genetic Recombination;Genetic Research;genetic variant;genome wide association study;genome-wide;Genomics;Graph;Health;Heritability;Human;Human body;human data;Human Genome;improved;In Vitro;Individual;Intake;Knowledge;Maintenance;Maps;Measures;Mediating;Mendelian randomization;model organism;mouse genome;Mus;natural hypothermia;Nature;Neighborhoods;novel;novel strategies;Orthologous Gene;Outcome;Pathway interactions;Persons;Phenotype;Population;Prevalence;Prevention strategy;Quantitative Trait Loci;Recurrent disease;Relapse;Reporter;Resolution;response;Risk Factors;Role;Sample Size;Signal Transduction;single-cell RNA sequencing;Societies;study population;Symptoms;therapeutic target;Tissues;trait;Transcript;translational approach;translational genetics;treatment strategy;Variant

PROJECT_TITLE: Translational genetic analysis in human and mouse GWAS to identify the genomic architecture of alcohol sensitivity and tolerance

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Contraception/Reproduction;Estrogen;Pediatric;Physical Injury - Accidents and Adverse Effects;Women's Health Research

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH Injuries to the anterior cruciate ligament (ACL) of the knee joint are rising, particularly for the female adolescent population, yet the mechanisms driving age- and sex-specific ACL tissue adaptations that may lead to increase injury risk are unclear. The goal of this proposal is to determine how the timing and level of sex hormones impact ACL bundle size and function. Such information will be critical to provide guidance for patient-specific injury risk and treatment algorithms.

PI_NAMEs: FISHER, MATTHEW B (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;Age;Age Months;age related;age related changes;Algorithms;Animals;Anterior Cruciate Ligament;anterior cruciate ligament injury;Area;Automobile Driving;Behavior;Biological Assay;Biomechanics;Cells;Childhood;Clinical Trials;Data;early adolescence;Estrogen Receptors;Estrogens;Estrus;Euthanasia;Evaluation;Exhibits;experience;Family suidae;Female;Female Adolescents;Funding;Geometry;Goals;Gonadal Steroid Hormones;Gonadotropins;Growth;Hormones;Human;immature animal;individualized medicine;Injury;Joint Laxity;Knee joint;Lateral;Link;Magnetic Resonance Imaging;male;Measures;Menstrual cycle;Methods;multidisciplinary;Ovulation;Patients;Periodicity;Persons;Phase;Population;porcine model;prevent;Progesterone;Progress Reports;Property;pubertal timing;Puberty;Public Health;receptor;Research;response;Risk;Risk Factors;Risk Reduction;Role;Serum;sex;skeletal;Structure;Testing;Testosterone;Time;tissue stress;Tissues;treatment group;treatment strategy;Work

PROJECT_TITLE: Role of Hormones on Bundle-Specific ACL Function in the Growing Knee Joint

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Down Syndrome;Eczema / Atopic Dermatitis;Intellectual and Developmental Disabilities (IDD);Pediatric

ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Individuals with Down syndrome (DS) often present with inflammatory skin diseases such as atopic dermatitis (AD) and alopecia areata (AA). They represent a vulnerable population that is seldom included in clinical trials. We propose a clinical trial to evaluate the long-term safety, efficacy, and mechanisms of two novel JAK1 (abrocitinib) and JAK3/TEC (ritlecitinib) inhibitors, recently FDA-approved for AD and AA respectively, in patients with DS, so that individuals with DS can be appropriately treated.

PI_NAMEs: BOGUNOVIC, DUSAN ;GUTTMAN, EMMA  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Adolescent;Adult;Affect;aged;Alopecia;Alopecia Areata;Alzheimer's disease risk;Area;Arthritis;Atopic Dermatitis;Attenuated;Autoantibodies;Autoimmune;Autoimmune Diseases;Biopsy;Blood;Body Surface Area;Cardiac;Case Series;Case Study;Celiac Disease;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromosome 21;Chronic;chronic inflammatory skin;Clinical Research;Clinical Trials;comorbidity;cytokine;Data;Dermatologic;Dermatology;Disease;disorder control;Dose;Down's Syndrome;Eczema;effective therapy;Erythema;Evaluation;experience;FDA approved;Genetic;Genetic Transcription;Goals;Hematological Disease;Hematology;Hidradenitis Suppurativa;Hypothyroidism;immune activation;Immune system;improved;indexing;Individual;Inflammation;Inflammatory;inhibitor;Insulin-Dependent Diabetes Mellitus;Intellectual functioning disability;Interferon Receptor;JAK1 gene;JAK2 gene;JAK3 gene;Joints;Measures;Molecular;Molecular Profiling;Monitor;Neoplasms;Neurobehavioral Manifestations;Newborn Infant;novel;novel therapeutics;Oral;Painless;Pathway interactions;patient oriented;Patient Outcomes Assessments;patient population;patient subsets;Patients;Peripheral;Pharmaceutical Preparations;phase 3 study;Phase II Clinical Trials;Physicians;Population;primary endpoint;Proteins;Proteomics;Protocols documentation;Psoriasis;Quality of life;Regimen;Reporting;Research Personnel;response;Rheumatoid Arthritis;Risk;Safety;Sampling;Scalp structure;Scientist;Severities;Severity of illness;side effect;Signal Transduction;single-cell RNA sequencing;Skin;skin disorder;standard of care;Symptoms;Testing;Time;tool;transcriptomics;treatment duration;United States;Vitiligo;Vulnerable Populations

PROJECT_TITLE: Use of specific JAK inhibition on inflammatory skin and scalp diseases in Down syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-B (56)]


ORG_DEPT: PATHOLOGY

PHR: Project Narrative The heart’s inability to make new muscle cells and resulting maladaptive remodeling of muscle structure and function is a key driver of heart failure. This project focuses on a factor that [1] prevents cardiac muscle cells from transitioning to pathologic immature states incompetent of mounting a proper growth response to cardiac stress and [2] controls the frequency with which muscle cells transition to stress-induced immature states, as we postulate the number of myocytes recruited into these states predicts the nature and severity of pathologic remodeling and ultimately heart failure. Thus the long-term goal of this project is therapeutically protecting the heart from these maladaptive immature state transitions by redeploying this factor in select cardiac muscle cells.

PI_NAMEs: DAVIS, JENNIFER MICHELLE (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Adult;aorta constriction;biological adaptation to stress;Biological Assay;Biological Markers;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac tissue engineering;Cell Nucleus;Clonal Expansion;Competence;Contracts;Data;Environment;Exercise;Failure;fetal;Frequencies;Gene Expression;Gene Expression Profiling;Generations;Genes;Genetic;Genetic Recombination;Genetic Transcription;Goals;Growth;Heart;Heart failure;heart function;heart preservation;Histologic;Histology;Human;Human Engineering;human induced pluripotent stem cells;human model;Hyperplasia;Hypertrophy;inducible Cre;Injury;Knock-out;Mediating;Membrane;Metabolic;Modeling;mosaic;Mosaicism;Mus;Muscle Cells;Muscle function;muscular structure;Myotonic Dystrophy;Nature;Nuclear;Nude Rats;overexpression;Pathologic;Patients;Performance;Phase;Physiological;Population;postnatal;postnatal development;preservation;pressure;prevent;programs;recruit;Reporter;response;RNA-Binding Proteins;role model;Severities;single nucleus RNA-sequencing;Stress;stress tolerance;stressor;Testing;Therapeutic;Time;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Transplantation;Width;Workload

PROJECT_TITLE: Integrating Transcriptome Reprogramming Into Cardiac Plasticity Regulatory Mechanisms

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: P30 _ CCDI_Data UseSupplement TITLE: Pilot study to link clinical and imaging data from the electronic medical record (EMR), Children's Brain Tumor Network (CBTN) and the Molecular Characterization Initiative (MCI). PROJECT NARRATIVE: We propose to conduct a pilot study in partnership with Amazon Web Services (AWS) and Children's Brain Tumor Network (CBTN) operations teams to 1) develop a pipeline to support automatic data extraction from the electronic medical record, 2) increase imaging data available through CBTN and CCDI and 3) connect MCI and CBTN data at the participant level.

PI_NAMEs: LYNCH, THOMAS JAMES (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: anti-cancer research;bioinformatics pipeline;Biological;Brain Neoplasms;Cancer Center Support Grant;cancer diagnosis;Central Nervous System Neoplasms;Child;Clinical;Clinical Data;cloud based;Communities;Comprehensive Cancer Center;Computerized Medical Record;Data;Data Collection;Data Element;data sharing;Ecosystem;electronic data;Enrollment;Genomics;Image;Institution;Link;Magnetic Resonance Imaging;Malignant Childhood Neoplasm;Malignant Neoplasms;member;Molecular;Newly Diagnosed;operation;Participant;Pediatric Hospitals;Pilot Projects;Positioning Attribute;Primary Neoplasm;Process;Resources;Site;tool;web services

PROJECT_TITLE: CCSG Supplement: To Enhance the Utility of Data Available through the Childhood Cancer Data Initiative (CCDI) Ecosystem

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Nutrition;Obesity

ORG_CITY: HERSHEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE Obesity is a worldwide health problem that greatly increases the risk for developing hypertension and cardiovascular disease. Despite this impact, the underlying causes and optimal therapeutic tools for obesity- related hypertension are still poorly understood. This proposal will identify mechanisms by which the protective hormone angiotensin-(1-7) may improve cardiovascular and metabolic functions in individuals with obesity hypertension, to hopefully enhance understanding of this disease.

PI_NAMEs: ARNOLD, AMY CHRISTINE (contact);GAMBOA, ALFREDO

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Acute;Address;angiotensin I (1-7);Angiotensins;Animal Model;Anti-Hypertensive Agents;Area;Blood Pressure;blood pressure elevation;blood pressure reduction;Blood Vessels;brachial artery;Cardiovascular Diseases;Cardiovascular system;Catecholamines;Chronic;Clinical;Clinical Data;Closure by clamp;contrast enhanced;Cross-Over Studies;Data;Development;Diameter;Disease;Double-Blind Method;endothelial dysfunction;Endothelium;Epidemic;Etiology;Glucose Clamp;glucose production;glucose uptake;Health;Hormones;Human;Hyperinsulinism;Hypertension;hypertensive;improved;Individual;Infusion procedures;innovation;Insulin;Insulin Resistance;insulin sensitivity;Intravenous;Knowledge;Laboratories;Measures;Mediating;Metabolic;metabolic profile;Methods;Modeling;mouse model;multidisciplinary;Muscle;Nerve;Nitric Oxide;novel;Obese Mice;Obesity;Obesity Related Hypertension;obesity treatment;Organ;Outcome;patient population;Patients;pharmacologic;Physiological;Placebo Control;Pure Autonomic Failures;Randomized;recruit;Renin-Angiotensin System;Research;response;Risk;Rodent Model;Role;shear stress;stable isotope;Testing;Therapeutic;tool;Ultrasonography;Vascular Endothelium;Vasodilation

PROJECT_TITLE: Angiotensin-(1-7) and Cardiovascular Derangements in Obesity Hypertension

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Pain Research

ORG_CITY: HANOVER

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project narrative Though placebo treatments are pharmacologically inert, they induce active neurobiological processes related to patients’ expectations, learned associations, perceived care and support, and hope for the future. Studying placebo treatments provides a window into these crucial context variables that will help understand vulnerability and resilience to mental health disorders and beyond. This project continues a successful program of research on the brain mechanisms of placebo effects, taking the work in new directions critical for understanding mental health.

PI_NAMEs: WAGER, TOR D. (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: active method;Acupuncture Therapy;Address;Affect;Affective;Alcohol abuse;Amygdaloid structure;Anxiety;Area;Awareness;base;Behavior;behavior measurement;behavior prediction;Behavioral;behavioral study;Biometry;Brain;brain based;Brain Diseases;brain pathway;Brain region;Cardiovascular Diseases;care providers;Caring;Characteristics;Clinical;clinical care;clinical pain;clinically significant;cognitive performance;cognitive process;Competence;Computer Models;Cues;Disease;Drug abuse;Electroencephalography;emotional distress;expectation;experience;Extinction;Fright;Functional Magnetic Resonance Imaging;Funding;Future;gastrointestinal function;Grant;healing;Health Promotion;Human;Implanted Electrodes;improved;Insula of Reil;Interpersonal Relations;Intervention;Learning;Mediating;Medical Students;Mental Depression;Mental disorders;Mental Health;mental state;Mind;mindfulness;Modeling;multidisciplinary;multimodality;Nature;negative affect;neural;Neurobiology;neurochemistry;neuroimaging;Neurologic;Neuronal Plasticity;Neurosciences;Operative Surgical Procedures;Pain;Pain management;Parkinson Disease;patient expectation;Patients;Pattern;Perception;Persons;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Placebo Effect;Placebos;Play;Process;programs;Protocols documentation;Provider;Psyche structure;psychologic;Psychotherapy;Quality of Care;Regulation;Relaxation;Research;resilience;Resistance;response;Safety;Sampling;Science;Shapes;Sleep;social;social influence;social neuroscience;Stimulus;substance use;Suggestion;Symptoms;System;Testing;Therapeutic Effect;Time;Work

PROJECT_TITLE: The neural bases of placebo effects and their relation to regulatory processes

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Metabolic disorders such as obesity, diabetes and insulin resistance involve the communication between metabolic organs. During the last grant award cycle, we defines the crosstalk between the vascular system and metabolic organs that fails in diabetes and insulin resistance. After the next five years, we will know more about this crosstalk during physiological condition and how its dysregulation contributes to obesity and other metabolic disorders.

PI_NAMEs: PI, XINCHUN  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Adipocytes;Adipose tissue;Affect;Award;beta-adrenergic receptor;Binding Proteins;Biochemical;Biological Assay;Biological Availability;Blood;Body System;Bone Morphogenetic Proteins;Carbon;Communication;Complex;Coupled;Data;detection of nutrient;Diabetes Mellitus;Diabetic mouse;Endocrine;Endothelial Cells;Endothelium;energy balance;Environmental Risk Factor;experimental study;Fasting;Fatty Acids;feeding;Food;Funding;Genetic;genetic variant;Gluconeogenesis;Glycerol;Grant;Hepatic;High Fat Diet;Homeostasis;Human;improved;insight;Insulin Resistance;insulin sensitivity;Knockout Mice;Lipase;Lipolysis;Liquid substance;Liver;Mediating;Metabolic;Metabolic Diseases;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Microscopy;Morphology;mouse model;Neurons;Nonesterified Fatty Acids;Nutrient;Nutrient availability;Obesity;obesity treatment;Organ;Overnutrition;Persons;Physiological;Plasma Proteins;PPAR alpha;Proteins;Reaction;Receptor Signaling;Refractory;Regulation;Regulator Genes;Repression;response;Rodent;Role;Serum;Signal Transduction;sterol esterase;Testing;Tissues;transcription factor;Vascular Endothelium;Vascular System

PROJECT_TITLE: Metabolic crosstalk through vascular endothelium-secreted factors


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Chicago

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Compared to APOE3, with APOE4 there is greater neurovascular dysfunction in aging and Alzheimer's disease. The proposed research is highly relevant to public health because it will explore a novel mechanism of how APOE contributes to neurovascular dysfunction in Alzheimer's disease.

PI_NAMEs: TAI, LEON MAING (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Acute;Address;Age;Aging;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;apolipoprotein E-3;apolipoprotein E-4;Behavior;Behavioral;Biology;Blood Vessels;Brain;brain endothelial cell;Cell Physiology;cell type;Cells;Cellular Metabolic Process;Central Nervous System;Cerebral endothelium;Chronic;Cognition;Data;Disease;Endothelial Cells;Environment;Exposure to;Functional disorder;fundamental research;gain of function;gene-targeted therapy;genetic risk factor;Genotype;Goals;Homeostasis;Human;Impaired cognition;In Vitro;in vivo;insight;Intercellular Fluid;knock-down;Knowledge;Link;Metabolic Pathway;Metabolism;Mitochondria;Molecular;Mus;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;Neurophysiology - biologic function;neurovascular;novel;Nutrient;Outcome;Oxidative Phosphorylation;Pathologic;Pathology;Pathway interactions;Peripheral;Physiological;Physiology;Plasma;Play;prevent;Public Health;Publishing;Reactive Oxygen Species;Research;Role;Side;Signaling Molecule;Stroke;Tamoxifen;Testing;therapeutic development;therapeutic target;Traumatic Brain Injury

PROJECT_TITLE: Deciphering molecular mechanisms that underlie brain endothelial cell dysfunction with APOE4

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-H (55)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: BLACKSBURG

ORG_DEPT: BIOLOGY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Invasive aspergillosis, caused by the filamentous fungus Aspergillus fumigatus, is a leading cause of death in immunocompromised patients. With the emergence of Azole-resistant A. fumigatus, improving existing therapies and understanding the molecular mechanism of fungal adaptation to antifungals is imperative. Our proposal will specifically study the role of the septin cytoskeleton in A. fumigatus response to the antifungal caspofungin using a combination of proteomics, genetic, molecular, cell biology, and in vivo approaches.

PI_NAMEs: VARGAS-MUNIZ, JOSE  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Address;Affect;anti-fungal agents;Aspergillosis;Aspergillus fumigatus;Azole resistance;base;beta-Glucans;Biology;Candida albicans;Candidate Disease Gene;Caspofungin;Cause of Death;Cell Cycle;Cell Cycle Progression;Cell membrane;Cell Physiology;Cell Wall;Cells;Cellular biology;Cellular Structures;Complex;Cytokinesis;Cytoskeleton;Death Rate;design;Drug Targeting;Etiology;Eukaryota;Exposure to;Family;fungicide;fungus;Gene Deletion;Genes;Genetic;Genetic Epistasis;Grant;GTP-Binding Proteins;Guidelines;Higher Order Chromatin Structure;Homeostasis;Human;human pathogen;Immunocompromised Host;improved;improved outcome;in vitro testing;in vivo;Incidence;knockout gene;Knowledge;Liquid substance;Mass Spectrum Analysis;Mediating;Molds;Molecular;mouse model;Mutagenesis;Neck;novel;novel therapeutic intervention;pathogenic fungus;Pathway interactions;patient population;Patient-Focused Outcomes;Pharmaceutical Preparations;Phosphopeptides;Phosphorylation;Phosphotransferases;Play;Post-Translational Protein Processing;Predisposition;Proteins;Proteomics;Recommendation;recruit;response;Role;Saccharomyces cerevisiae;scaffold;Scaffolding Protein;Signal Transduction;Solid;Stress;Structure;success;Susceptibility Gene;targeted treatment;Testing;Treatment outcome;Vascular Plant

PROJECT_TITLE: Elucidating the molecular mechanisms of septin-dependent drug response to the antifungal caspofungin in the human pathogen Aspergillus fumigatus

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunization;Immunotherapy;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Vaccine Related

ORG_CITY: SAN ANTONIO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Public Health Relevance/Narrative Cancer represents a significant public health burden. We are studying an immune cell population playing an essential function during tumor vaccine therapies. The knowledge of these cells will lay the basis for improving current tumor vaccine therapies.

PI_NAMEs: ZHANG, NU  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Acute;acute infection;Address;Adjuvant;Advanced Malignant Neoplasm;Antigens;Biology;Cancer Patient;cancer vaccination;Cancer Vaccines;CD8-Positive T-Lymphocytes;Cells;Cellular biology;Chronic;Defect;Development;draining lymph node;Exhibits;experience;Future;Genetic Induction;genetic signature;Genetic Transcription;Germ Cells;Immune;immune checkpoint blockade;Immune response;Immunity;improved;improved outcome;in vivo;Infiltration;insight;Investigation;Knowledge;Lymph Node Tissue;Lymphoid;Malignant Neoplasms;Memory;migration;Minor;Modeling;mouse model;Mucous Membrane;Names;neoplasm immunotherapy;novel;Organ;pathogen;Patients;Pattern;Play;Population;prevent;Process;progenitor;programs;Property;Public Health;public health relevance;rational design;Recording of previous events;Residencies;response;Series;Site;stem;stem cell differentiation;stem cell population;stem cells;Surface;System;T cell differentiation;T cell response;T cell therapy;T cell transcription factor 1;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Testing;therapy design;tissue resident memory T cell;Tissues;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Transforming Growth Factors;Transgenic Organisms;translational potential;Travel;tumor;Tumor Immunity;tumor microenvironment;vaccine efficacy;vaccine response;Vaccine Therapy;Virus Diseases

PROJECT_TITLE: Lymphoid residency of Tcf-1+ CD8+ T cells during tumor vaccine responses


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Immunotherapy;Organ Transplantation;Orphan Drug;Prevention;Rare Diseases;Transplantation

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Long-term survival of transplanted heart grafts without the need for chronic use of immunosuppression will provide a better quality of life for organ transplant recipients. The proposed studies will explore innovative ways to achieve immunosuppressive drug-free long-term patient survival after heart transplantation.

PI_NAMEs: EZZELARAB, MOHAMED B (contact)

PROGRAM_OFFICER_NAME: SHAW, JULIA M

PROJECT_TERMS: allograft rejection;Allografting;Attenuated;Biodistribution;Cell Therapy;chimeric antigen receptor;Chronic;Clinical;clinical translation;clinically relevant;Clonal Expansion;Clone Cells;cytokine;Data;Development;effector T cell;Endothelial Cells;Engineering;Exhibits;Feedback;Foundations;Functional disorder;Generations;graft dysfunction;Graft Rejection;Graft Survival;heart allograft;Heart failure;Heart Injuries;Heart Transplantation;Home;humanized mouse;IL7 gene;IL7R gene;Immunity;Immunosuppression;Immunosuppressive Agents;Immunotherapy;in vivo;Incidence;Inflammatory;Inflammatory Response;Infusion procedures;Injury;innovation;Interleukin 7 Receptor;Interleukin-15;interleukin-15 receptor;Interleukin-6;Interleukins;islet allograft;loss of function;Mediating;migration;Molecular;Monkeys;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;neutralizing monoclonal antibodies;nonhuman primate;novel;organ transplant recipient;Oxidative Stress;Pathogenicity;Patients;Play;prevent;Prevention;Production;Quality of life;Reactive Inhibition;Reactive Oxygen Species;Reagent;receptor;Regulatory T-Lymphocyte;Research;Resistance;Resources;Rhesus;Rodent;Role;T cell regulation;T cell therapy;T memory cell;T-Lymphocyte;Testing;Therapeutic;Time;Tissues;Treatment Efficacy;Treg therapy;United States National Institutes of Health

PROJECT_TITLE: Mechanisms and Therapeutic Targeting of T cell Regulation in Heart Allograft Recipient Monkeys


NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_DEPT: PHARMACOLOGY

PHR: Expansion and superior functionality are hallmarks of fetal hematopoietic stem cells. The Notch signaling pathway is essential for function and maturation of hematopoietic stem cells while in the fetal liver, and we propose to identify how the signaling in the fetal niche regulates the expression of novel target genes, which lead to expansion of fetal hematopoietic stem cells. We will use this knowledge for the therapeutic expansion of cord blood cells and rejuvenation of adult bone marrow stem cells.

PI_NAMEs: PAJCINI, KOSTANDIN  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Ablation;Acclimatization;Address;Adult;Affect;aged;Animal Model;antimicrobial;Biological;Biological Assay;Biological Models;Biology;Blood Cells;bone aging;Bone Marrow;Bone Marrow Stem Cell;cathelicidin;cathelicidin antimicrobial peptide;cell type;Cells;Complex;Core-Binding Factor;Cytoplasmic Granules;Data;Embryonic Development;Engraftment;experimental study;Family;Family member;fetal;Fetal Development;Fetal Liver;fetal stem cell;fitness;Gene Deletion;Genes;Genetic Transcription;Growth;Hematopoiesis;Hematopoietic;hematopoietic gene;hematopoietic stem cell expansion;Hematopoietic Stem Cell heterogeneity;Hematopoietic stem cells;hemogenic endothelium;Impairment;improved;in vivo;Knowledge;Label;Ligands;liver development;Megakaryocytes;Methodology;Multipotent Stem Cells;Mus;Myelogenous;Myeloid Progenitor Cells;neutrophil;notch protein;Notch Signaling Pathway;novel;Pathway interactions;Peptides;Physiological;Play;Population;postnatal;Process;progenitor;Proliferating;Protein Secretion;Proteins;Publishing;rapid growth;receptor;Receptor Activation;Recommendation;reconstitution;Rejuvenation;Reporter;Role;Running;self-renewal;Signal Pathway;Signal Transduction;single cell analysis;Site;Source;stem cell expansion;stem cell function;stem cell growth;stem cell proliferation;stem cell survival;Surface;Testing;Text;Therapeutic;Time;Tissues;transcriptome sequencing;Transgenic Animals;Transgenic Model;Transgenic Organisms;Transplantation;Umbilical Cord Blood;Venus;Visualization;Work

PROJECT_TITLE: Notch signaling regulates stem cell function in the fetal liver hematopoietic niche

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Aging;Asthma;Behavioral and Social Science;Clinical Research;Lung;Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Walking impairments are debilitating and common but poorly understood in older persons with asthma (OPWA). This study will examine the effects of brain structure and function, controller medication adherence and asthma control on walking performance in 240 persons with and without asthma age 60-80 years. The expected findings will shed light on underlying asthma-specific brain circuitry disruptions, and modifiable disease management targets that will inform physical, cognitive, and pharmacological treatments to improve walking, prevent mobility impairments, and improve related health outcomes among OPWA.

PI_NAMEs: FELDMAN, JONATHAN M.;HOLTZER, ROEE  (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Address;Age;Aging;Asthma;Attention;Attenuated;Behavioral;biobehavior;Brain;brain circuitry;brain control;brain magnetic resonance imaging;Cognition;Cognitive;cognitive function;cognitive performance;Cognitive Therapy;comparison control;Dementia;design;Disease;Disease Management;Electronics;Exhibits;functional near infrared spectroscopy;Gait abnormality;Gait speed;gray matter;Health;Hemoglobin;human old age (65+);Impaired cognition;improved;Intervention;Knowledge;Learning;Literature;Locomotion;Magnetic Resonance Imaging;Measurement;Measures;medication compliance;Meta-Analysis;Methods;Mobility decline;Morbidity - disease rate;mortality;neural;Neurologic;Neurologic Examination;normal aging;novel marker;older adult;Older Population;Outcome;Outcome Study;Patient Self-Report;Pattern;Performance;Persons;Pharmacological Treatment;poor health outcome;Population;Prefrontal Cortex;Prevalence;prevent;Process;Protocols documentation;Public Health;Publishing;pulmonary function;Recording of previous events;Resources;Risk;Sampling;Structure;System;Thick;Walking;walking performance;walking speed;white matter

PROJECT_TITLE: The influence of asthma on walking in older adults: brain predictors, medication adherence and asthma control

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Pediatric;Physical Rehabilitation;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

PHR: PROJECT NARRATIVE The proposed research will address finding barriers to speech therapy services for underrepresented populations to ascertain their access to health care services. To achieve this, we will use MarketScan databases to evaluate access to speech therapy services. Completion of this project will advance the candidate’s pursuit of addressing health care disparities for underrepresented populations as it relates to receiving speech therapy and health care services as an independent clinical research scientist.

PI_NAMEs: SUDA, KJ  (contact)

PROGRAM_OFFICER_NAME: ELWOOD, WILLIAM N

PROJECT_TERMS: Address;administrative database;Adolescent;adverse event risk;Affect;Algorithms;Anxiety;Asian;barrier to care;Behavioral Research;biomedical referral center;Black race;career;Caring;Characteristics;Child;Childhood;Cleft Palate;Clinical;Clinical Research;cohort;Communication;Communities;Data;Data Set;Databases;Dental;Dental General Practice;Development;Diagnosis;Disease;Economic Burden;effective intervention;Exhibits;Face;Family;Family psychotherapy;follow-up;Foundations;Funding;Future;Goals;Grant;Health;health care availability;health care disparity;health care service;Health Disparities Research;health disparity;Health Insurance;Health Services Research;Health system;Healthcare;high risk;human old age (65+);Improve Access;improved;Individual;Insurance;interest;Intervention;Interview;Knowledge;Latinx;Leadership;Left;Literature;Loneliness;Long-Term Effects;Medical;Mental Depression;Mentors;Methodology;minority children;Nasal cavity;Occupational;Operative Surgical Procedures;Oral;Otolaryngologist;Outcome;palate repair;Parents;patient safety;Patients;Pediatric Hospitals;pediatric patients;Personal Satisfaction;Pharmaceutical Preparations;Pharyngeal structure;Policies;Population;Privatization;programs;Publishing;Qualitative Methods;Qualitative Research;Recommendation;repaired;Research;Research Methodology;Research Personnel;Risk Reduction;Schedule;Scientist;secondary analysis;Services;skills;social;Social Problems;Socialization;socioeconomics;sound;Speech;Speech Disorders;Speech Intelligibility;Speech Therapy;success;Therapeutic Intervention;Training;Translating;Transportation;Underrepresented Populations;Work

PROJECT_TITLE: Pediatric Adverse Event Risk Reduction for High Risk Medications in Children and Adolescents: Improving Pediatric Patient Safety in Dental Practices


ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE – OVERALL Compared to patients in the US, Nigerian patients present with colorectal cancer at a younger age and with more advanced disease and worse survival. While the reasons for these disparities are multi-factorial, our NIH-funded studies suggest unique biology and a potential role for immunotherapy in improving outcomes. The Nigerian Immuno-Oncology Research (NOLA) program will synergize our existing strengths in global cancer disparities research and immuno-oncology to address clinically meaningful questions regarding colorectal cancer immunobiology and clinical care of patients with immunotherapy in Nigeria, and how these factors can be leveraged to address colorectal cancer disparities.

PI_NAMEs: ALATISE, OLUSEGUN ISAAC;KINGHAM, T PETER (contact);SANCHEZ VEGA, FRANCISCO

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Address;advanced disease;Africa South of the Sahara;African;Age;American;Area;Atlases;biobank;Biological;Biological Factors;Biological Markers;Biological Specimen Banks;Biology;Blood Banks;Cancer Center;cancer health disparity;cancer immunobiology;Cancer Patient;Cells;chemotherapy;Clinical;clinical care;Collaborations;colon cancer patients;Colorectal Cancer;Complex;cost;Country;Data;Data Collection;data management;Data Set;data sharing;Databases;Diagnosis;Disease;Disparity;diverse data;effective therapy;Ensure;Ethnic Population;European ancestry;falls;Fluorouracil;Fostering;Frequencies;Funding;Future;Genetic;Goals;Health Disparities Research;health disparity;Immune;immune cell infiltrate;Immunobiology;immunogenic;Immunologic Factors;Immunooncology;Immunotherapy;immunotherapy trials;improved outcome;Incidence;Income;indexing;Infrastructure;Knowledge;low and middle-income countries;Malignant Neoplasms;Medical Oncologist;Memorial Sloan-Kettering Cancer Center;Mentorship;Microsatellite Instability;Microsatellite Repeats;modifiable risk;multidisciplinary;neoplastic cell;Nigeria;Nigerian;Oncology;Oncology Group;Operative Surgical Procedures;Outcome;Pathologic;Pathologist;Patient Care;Patient Selection;Patients;Phenotype;Pilot Projects;Population;programs;prospective;racial population;Radiation;Research;Research Personnel;Research Priority;Research Project Grants;Resources;response;Risk Factors;Role;side effect;Specimen;standard of care;Structure;Surgeon;synergism;Therapeutic;Toxic effect;transcriptome sequencing;tumor;tumor microenvironment;tumor-immune system interactions;Underrepresented Populations;United States National Institutes of Health;whole slide imaging;Work

PROJECT_TITLE: Addressing cancer disparities in Nigeria through Immuno-oncology Research – The NOLA Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (J1)]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: KINGHAM, T PETER (contact)

PROJECT_TERMS: Address;Advisory Committees;Africa South of the Sahara;African;anti-cancer research;Applications Grants;authority;Awareness;biobank;Biological Factors;Biology;cancer care;cancer health disparity;Cancer Patient;Collaborations;Colorectal Cancer;Colorectal Polyp;Communication;Communities;Complex;Data;Data Analyses;data management;data resource;data sharing;Decision Making;Diagnosis;Discipline;Disparity;editorial;Educational Curriculum;Ensure;Epidemiologist;Evaluation;experience;Faculty;Fostering;Foundations;Funding;Future;Goals;Grant;health disparity;Human Resources;Immunobiology;Immunooncology;improved;Infrastructure;Institution;interest;International;Lead;Leadership;low and middle-income countries;Malignant Neoplasms;Manuscripts;Medical;Medical Oncologist;meetings;member;Mentorship;metabolomics;Monitor;multidisciplinary;Nigeria;Nigerian;Office of Administrative Management;Oncology;Oncology Group;online repository;Operations Research;Outcome;Pathologist;Pathology;Patient Compliance;patient privacy;Patients;Play;point of care;Positioning Attribute;Preparation;Process;Productivity;Program Evaluation;programs;Regional Cancer;Regulation;Research;Research Personnel;Research Project Grants;research study;Research Support;Resources;Risk Factors;Role;Science;Services;Site;Slide;social health determinants;success;symposium;synergism;System;Teaching Hospitals;Training;Training Programs;translational scientist;United States National Institutes of Health;Universities;Urine;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy

PROJECT_TERMS: Address;American;Artificial Intelligence;Basic Science;biobank;Biological Markers;Biology;Cancer Control;cancer health disparity;cancer immunobiology;Cancer Patient;cell type;Cells;Classification;Clinical;Clinical Research;cohort;Collaborations;college;colon cancer patients;Colorectal Cancer;Comparative Study;cost effective;Country;Data;Data Set;Diagnosis;digital pathology;Disparity;Epithelium;Foundations;Freezing;Future;Goals;High-Frequency Microsatellite Instability;Immune;immune checkpoint blockade;Immunobiology;immunogenic;immunogenicity;Immunohistochemistry;Immunooncology;Immunotherapeutic agent;Immunotherapy;immunotherapy trials;improved;Income;insight;Investigation;low and middle-income countries;Methods;Microsatellite Instability;multimodality;Nigeria;Nigerian;novel;Outcome;outcome disparities;Pathologist;pathology imaging;patient stratification;Patients;Phase;Population;programs;Protocols documentation;rational design;Research;Research Project Grants;Research Support;Resected;resistance mechanism;Resolution;Resources;response;scale up;single cell analysis;Slide;Specimen;success;Suspensions;Techniques;therapeutic target;transcriptome sequencing;transcriptomic profiling;Translating;Translational Research;tumor;tumor immunology;tumor microenvironment;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;whole slide imaging;Work

PROJECT_TITLE: Research Project


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Mutations in ASNA1 result in human cardiomyopathy, highlighting its importance for cardiac function. However, little is known as to the specific role of ASNA1 in cardiomyocytes, and how mutations in ASNA1 result in cardiomyopathy. Proposed studies are aimed at understanding the function of ASNA1 in cardiac muscle at the molecular, cellular, and physiological levels, and gaining insights into mechanisms by which mutations in ASNA1 cause cardiomyopathy.

PI_NAMEs: CHEN, JU  (contact)

PROJECT_TERMS: Ablation;Address;Adult;Alleles;Apoptosis;Arsenites;ATP phosphohydrolase;Autophagocytosis;Binding;Biogenesis;Biology;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiomyopathies;Cell membrane;Cellular Membrane;Cessation of life;Childhood;clinically relevant;Complex;Defect;Development;Dilatation - action;Dilated Cardiomyopathy;Embryo;Endoplasmic Reticulum;Exhibits;genetic manipulation;Goals;Golgi Apparatus;Heart;Heart Abnormalities;heart function;Heterozygote;Homologous Gene;Human;human induced pluripotent stem cells;Hydrophobicity;Impairment;Individual;induced pluripotent stem cell derived cardiomyocytes;infancy;insight;Integral Membrane Protein;Knock-in;Knockout Mice;Knowledge;Lead;lipid biosynthesis;loss of function;LoxP-flanked allele;Mediating;Membrane;Membrane Proteins;Missense Mutation;Modeling;Molecular;Molecular Chaperones;Morphogenesis;mouse model;Mus;Mutant Strains Mice;Mutation;Myocardium;new therapeutic target;Nonsense Mutation;novel;Nuclear Envelope;null mutation;Outer Mitochondrial Membrane;Pathway interactions;Patients;Perinatal mortality demographics;Phenotype;Physiological;Play;postnatal;Process;Protein Family;Proteins;Proteome;Quality Control;receptor;Role;SGTA gene;Structure;Tail;Thinness;Tissues;trafficking;Transgenic Mice;Transmembrane Domain;Ventricular

PROJECT_TITLE: Molecular basis of ASNA1 cardiomyopathy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Prevention

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Over 30 million adults in the U.S. have type 2 diabetes, which can result in devastating complications such as strokes, kidney failure, and amputation if not well-managed. Day-to-day self-management by adults with type 2 diabetes, including glucose monitoring, taking medications, and healthy habits, is essential to avoid diabetes complications, yet, despite the rapidly expanding availability of wearable glucose and activity monitors, successful self-management remains challenging for many. This research aims to develop and test an approach to help adults use their personal diabetes information from wearable devices to achieve and sustain healthy diabetes self-management, which will reduce diabetes complications, and improve health and quality of life for people with type 2 diabetes.

PI_NAMEs: LOW, CARISSA A;ROSLAND, ANN-MARIE  (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: Accelerometer;Adult;Amputation;arm;Behavior;behavior change;Behavior Therapy;Behavioral;Chronic;Clinical;clinical research site;Clinical Trials;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Data;Data Display;data platform;Data Reporting;data visualization;design;diabetes distress;diabetes education;diabetes management;Diabetes Mellitus;diabetes self-management;efficacy clinical trial;efficacy trial;empowerment;Enrollment;evidence base;feasibility trial;Feedback;fitbit;Friends;Future;Glucose;glucose monitor;Glycosylated hemoglobin A;Goals;Habits;Health;Health behavior;health data;health literacy;Health Status;human centered design;improved;Informal Social Control;innovation;insight;interactive visualization;Intervention;Intervention Trial;Interview;Kidney Failure;Knowledge;Link;Methods;Modernization;Monitor;Motivation;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Participant;Patients;Persons;Pharmaceutical Preparations;pilot test;pilot trial;Preparation;Protocols documentation;Quality of life;Randomized;randomized trial;recruit;Research;response;Risk Reduction;Sampling;Self Determination;Self Management;Site;Stroke;Structure;success;Techniques;Testing;theories;Time;tool;Treatment Efficacy;trend;Visualization;wearable device;wearable monitor;web platform

PROJECT_TITLE: Patient-generated health data connections to empower diabetes management success


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

ORG_CITY: FULLERTON

ORG_NAME: CALIFORNIA STATE UNIVERSITY FULLERTON

PHR: Project Narrative  Project EAGER: Guiding CSUF students to genomics graduate programs through curriculum development, mentorship, research, and inclusive support. Bridging opportunity gaps and empowering diverse undergraduates for impactful contributions in genomics. Fostering a community of aspiring scientists prepared for successful graduate careers.

PI_NAMEs: BACHTROG, DORIS ;BEHSETA, SAM ;DER, JOSHUA ;HUELSENBECK, JOHN P.;NIKOLAIDIS, NIKOLAS  (contact)

PROGRAM_OFFICER_NAME: HERNANDEZ-RAMON, ELENA ESTELA

PROJECT_TERMS: Academic support;Address;Adoption;Automobile Driving;California;career;Career Choice;career development;cohort;Collaborations;collaborative environment;Communication;Communities;community building;community organizations;Consultations;cultural competence;curriculum development;Development;Disparity;Ecosystem;Education;Educational Curriculum;Educational Models;Educational process of instructing;Educational workshop;Elements;empowerment;Ensure;Environment;Equity;Event;experience;Face;Faculty;faculty mentor;Financial Support;Fostering;Foundations;Funding;Future;Genomics;Goals;hands on research;Height;Individual;Industry;Infrastructure;innovation;Institution;Institutionalization;Interdisciplinary Education;interest;Joints;Knowledge;Laboratories;laboratory experience;Learning;matriculation;meetings;Mental Health;Mentors;Mentorship;Methodology;Mission;Modeling;next generation;Organizational Culture;outreach;Personal Growth;Personal Satisfaction;Phase;Play;pressure;programs;project-based learning;real world application;Records;Recruitment Activity;Research;Research Personnel;Resources;Role;Scientist;Shapes;skill acquisition;skills;social;social organization;STEM career;Student Selections;Students;success;summer research;support network;Teaching Method;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;virtual;virtual platform;Vision;Work

PROJECT_TITLE: Project EAGER: Enabling Access to Genomics Experience and Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-M (J2)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BINGHAMTON

ORG_DEPT: CHEMISTRY

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Project Narrative  This project explores the structural basis of key molecular interactions that are responsible for the cellular membrane disruption induced by amyloidosis of b-amyloid peptides. The outcomes will provide insights on the pathological roles of both Ab amyloidogenic aggregates and cellular plasma membranes in Alzheimer’s disease.

PI_NAMEs: QIANG, WEI  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: aggregation pathway;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;Amyloid Fibrils;amyloid peptide;Amyloidosis;Binding;Biological Assay;C-terminal;Cell Line;Cell membrane;Cells;Cellular Assay;cellular imaging;Cellular Membrane;Defect;Detergents;Development;Environment;Experimental Designs;experimental study;Extravasation;Fluorescence;Freezing;Funding;Future;Goals;Heterogeneity;Human;Hydrophobicity;Individual;insight;Kinetics;Knowledge;Lead;Lipids;Liposomes;Location;Measurement;Membrane;Methodology;Methods;Modeling;Molecular;Molecular Conformation;Molecular Probes;Monitor;Mus;Nature;Neuroblastoma;Neurons;neurotoxic;neurotoxicity;NMR Spectroscopy;Nuclear;Outcome;Pathologic;Pathway interactions;Peptides;Permeability;Process;Relaxation;Resolution;Role;Sampling;solid state nuclear magnetic resonance;Spectrum Analysis;System;Techniques;Time;Toxic effect;Vertebral column;Water

PROJECT_TITLE: Molecular Structural Basis of Non-specific Neuronal Membrane Disruption Induced by Early-Stage Beta-Amyloid Peptide Aggregation

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Serious Mental Illness

ORG_CITY: STONY BROOK

ORG_DEPT: PSYCHIATRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: This project will test whether depression encompasses two distinct subtypes: chronic-intermittent and time- limited. We will leverage a cohort of 550 females who were studied previously from age 14 to 21 and will now follow them to age 26 to learn about causes and consequences of these subtypes. Our findings will help to better guide research and services to address the high burden of depression.

PI_NAMEs: KLEIN, DANIEL N;KOTOV, ROMAN I (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Address;Adolescent;Adolescent Development;Adult;Age;Characteristics;childhood adversity;Chronic;chronic depression;Clinical;cohort;Data;depression model;Depressive disorder;design;Deterioration;Development;Diagnostic;disability;Disease;disorder subtype;Dopamine;DSM-V;early adolescence;Electroencephalography;Electrophysiology (science);emerging adult;Emotional;Emotions;Etiology;Event;experience;Exposure to;Family;feasibility testing;Female;follow-up;Functional impairment;Genetic Complementation Test;health service use;Heterogeneity;high risk;high risk population;Image;Impairment;Incidence;indexing;Intervention;Learning;Life;Literature;Longitudinal Studies;machine learning method;Magnetic Resonance Imaging;Measures;Mediating;Mental Depression;Mental Health;Mental Health Services;Modality;Modeling;neuromelanin;novel;Occupational;Outcome;Pathway interactions;Patient Self-Report;Personality;Personality Traits;Persons;Pharmacotherapy;Phenotype;Placebo Effect;Population;prediction algorithm;prospective;Psychotherapy;Public Health;Recording of previous events;Recurrence;Research;Resolution;Rewards;Risk;Risk Factors;Role;Sampling;Selection for Treatments;Services;Signal Transduction;social;stressor;Subgroup;suicidal;Symptoms;System;Testing;theories;therapy development;Time;treatment response;Typology;Ventral Tegmental Area;Woman;young adult;young woman

PROJECT_TITLE: Developmental pathways model of depression heterogeneity

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Prevention;Rehabilitation;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Demographically, aging and neurodegenerative conditions are projected to steadily rise; individuals with these characteristics and conditions are more likely to require surgical interventions for underlying conditions and are at increased risk for the development of Perioperative Neurocognitive Disorders (PNDs) that will soon reach epidemic proportions. Currently, there are no therapies that can mitigate this inexorable rise in PNDs which results in decreased quality of life, higher mortality and is estimated to incur annual US healthcare costs in the 1st year after diagnosis of ~ $33 billion. By establishing that sgp130Fc, selective IL-6 trans- signaling blocker, can safely reduce the vulnerability of high-risk mouse models for PNDs, a pharmaceutical preparation (olamkicept) currently undergoing successful Phase II trials for inflammatory bowel disease (another IL-6 trans-signaling condition), can be repurposed for randomized clinical trials to prevent and/or treat PNDs in high-risk patients.

PI_NAMEs: MAZE, MERVYN  (contact);TERRANDO, NICCOLO

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: AD transgenic mice;Address;Adult;Affect;age effect;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Model;Attenuated;Behavior;Behavioral Assay;biomarker development;blood-brain barrier disruption;blood-brain barrier permeabilization;bone fracture repair;bone healing;Brain;Caregivers;cell type;Cells;Characteristics;Clinical;Clinical Research;Clinical Trials;cohort;combat;Complication;cost;cytokine;Data;Delirium;Dementia;Development;Diagnosis;early onset;efficacy evaluation;efficacy study;Epidemic;Female;follow-up;Formulation;Foundations;Fright;functional independence;Gene Proteins;General Anesthesia;Genetic;Health Care Costs;Healthcare Industry;high risk;Hippocampus;Immune;Impaired cognition;Impairment;In Vitro;in vivo;inattention;Individual;Infection;Inflammatory;Inflammatory Bowel Diseases;Interleukin-6;Interruption;Intervention Studies;Investigation;Life;Lung infections;male;Mediating;Memory;Memory impairment;Memory Loss;Meta-Analysis;Modeling;mortality;mouse model;Mus;Nerve Degeneration;neurocognitive disorder;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurons;old mice;older adult;older patient;Operative Surgical Procedures;Orthopedic Surgery;Output;Ovariectomy;overexpression;Patients;Perioperative;Pharmaceutical Preparations;Phase;phase II trial;Phosphorylation;Play;Population;Postoperative Period;postoperative recovery;pre-clinical;prevent;Prevention;Procedures;Process;prophylactic;Proteins;Quality of life;randomized, clinical trials;Recovery;regenerative;Reporting;Risk;Role;Safety;safety study;Severities;sex;Signal Transduction;single-cell RNA sequencing;Site;spatial memory;STAT protein;Stat3 protein;Symptoms;Syndrome;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tibial Fractures;Tissue-Specific Gene Expression;Transgenic Organisms;Up-Regulation;Wild Type Mouse;wound healing

PROJECT_TITLE: IL-6 Trans-signaling increases vulnerability to Postoperative Cognitive Decline in Aging and Alzheimers Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


ORG_CITY: DETROIT

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative A better understanding of the mechanisms regulating response to anti-HER2 antibodies is critical for the development of improved clinical strategies, and the inclusion of a diverse patient population and consideration of group- and individual-level genetic differences is essential for ensuring that these strategies are equitable. This work will provide the basis for moving towards a more race-inclusive, equity-focused precision medicine approach to the use of immunotherapies to improve overall treatment response, identify novel biomarkers, and reduce racial disparities in outcomes.

PI_NAMEs: GIBSON, HEATHER MARIE;PURRINGTON, KRISTEN S. (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Acceleration;adaptive immunity;Age;Antibodies;Antibody Therapy;Area;Autoimmunity;Biological;Biological Factors;Black race;black women;Breast Cancer Epidemiology;Cancer Biology;Cancer Burden;cancer health disparity;cancer site;CD8-Positive T-Lymphocytes;Censuses;Characteristics;Chicago;Cities;Clinical;Cohort Studies;Collaborations;Comprehensive Cancer Center;County;Development;Diagnosis;Disparity;Ensure;Environment;Equity;ERBB2 gene;experience;Face;Funding;Future;Gene Frequency;Genes;Genetic;Genetic Variation;Goals;Grant;Guidelines;Health Disparities Research;health disparity;Home;Household;Immune;Immune Tolerance;Immunooncology;immunoregulation;Immunotherapy;improved;Income;Individual;Infiltration;Infrastructure;innovation;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Medically Underserved Area;member;metropolitan;Michigan;Modeling;Monoclonal Antibodies;multi-ethnic;multidisciplinary;Natural Immunity;New Agents;novel marker;Outcome;Pathway interactions;patient population;Patient Self-Report;Patients;Population Heterogeneity;Poverty;precision medicine;Productivity;Prognosis;Race;racial difference;racial disparity;Recurrence;Regulation;Research Personnel;Research Project Grants;response;Role;sociodemographic factors;standard care;Structure;Translational Research;Trastuzumab;treatment response;tumor;Tumor Immunity;tumor-immune system interactions;United States Health Resources and Services Administration;Universities;White Women;Work

PROJECT_TITLE: Disparities in Immuno-oncology Outcomes in Detroit (DIODE)


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Immunotherapy;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative The Administrative Core contributes to the overall efficiency of the P20 by centralizing and leveraging the existing administrative infrastructure of the Karmanos Cancer Institute (KCI), an NCI-designated Comprehensive Cancer Center, thereby streamlining processes and eliminating duplication of effort. This robust administrative infrastructure conserves the resources of KCI’s Research Administration and allows investigators the ability to concentrate on the science of this P20, establish meaningful and productive multidisciplinary collaborations, and develop large-scale extramural grant submissions.

PI_NAMEs: SCHWARTZ, ANN G. (contact)

PROJECT_TERMS: Advisory Committees;Antibody Therapy;Applications Grants;Cancer Center;Cancer Center Support Grant;Collaborations;Communication;Comprehensive Cancer Center;Development;Disparity;Ensure;ERBB2 gene;Extramural Activities;Genetic;Goals;Grant;Health Disparities Research;health disparity;Health Sciences;Immunooncology;Immunotherapy;Infrastructure;innovation;Institution;Interdisciplinary Study;Leadership;Macrophage;Malignant Neoplasms;meetings;Molecular Epidemiology;Monitor;National Cancer Institute;Occupational activity of managing finances;Outcome;Participant;Process;Productivity;programs;racial difference;Regulation;Research;Research Institute;Research Personnel;Research Project Grants;Resources;response;Science;social health determinants;Structure;System;timeline;Translational Research;tumor immunology;United States National Institutes of Health


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunization;Immunotherapy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: Project Narrative Elucidation of the mechanisms regulating this process will unveil critical signatures that may distinguish therapeutic success or failure and contribute to health disparities. A better understanding of hereditary immune regulators may lead to novel co-therapeutic drug development, and better biomarkers to guide clinical decision- making.

PI_NAMEs: GIBSON, HEATHER MARIE (contact)

PROJECT_TERMS: adaptive immunity;Affect;African ancestry;Age;Animal Model;Antibodies;Antibody Therapy;antibody-dependent cellular phagocytosis;Antigen Presentation;Binding;Biological;Biological Assay;Biological Markers;Biological Response Modifiers;black patient;Black Populations;Black race;black women;Blood specimen;Breast Cancer Risk Factor;Candidate Disease Gene;CD8-Positive T-Lymphocytes;Cells;Chromosome 10;Chromosome 6;Classification;Clinical;clinical decision-making;Code;Cytometry;Data;density;design;Diagnosis;Disease-Free Survival;Disparity;drug development;Epidermal Growth Factor;Equity;Excision;Exhibits;experience;Failure;Fc Receptor;Gene Frequency;Genes;Genetic;genetic linkage analysis;Genetic Polymorphism;Genetic Variation;genomic locus;Genotype;Growth Factor;health care disparity;health disparity;Heterozygote;Human;Human Chromosomes;Image;Immune;immune activation;immune cell infiltrate;Immunologist;Immunooncology;Immunotherapy;improved;Inbred Mouse;Inflammatory;Inherited;interest;Lead;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Measures;Mediating;Methods;Minor;Modeling;Monoclonal Antibodies;mouse model;multiplexed imaging;Mus;Natural Immunity;Natural Killer Cells;Neoadjuvant Therapy;novel;Operative Surgical Procedures;Orthologous Gene;Outcome;overexpression;Pathway interactions;Patient Self-Report;Patient-Focused Outcomes;Patients;Pattern;peripheral blood;Phagocytosis;Play;Population;Population Heterogeneity;Pre-Clinical Model;preclinical study;Process;Proteins;Quality of Care;Race;receptor;Recombinants;Recurrence;Relapse;response;Role;Sampling;Scheme;Scientist;Signal Transduction;Single Nucleotide Polymorphism;single-cell RNA sequencing;socioeconomic disparity;Socioeconomic Factors;Stage at Diagnosis;Stains;success;T cell infiltration;T-Cell Activation;T-Lymphocyte;Technology;Testing;Therapeutic;therapy outcome;Time;Toxic effect;transcriptomics;Trastuzumab;Treatment outcome;tumor;Tumor Antibodies;Tumor Antigens;tumor heterogeneity;Tumor Immunity;Tumor Tissue;Tumor-infiltrating immune cells;Validation;Variant

PROJECT_TITLE: Project 1


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Regenerative Medicine

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: Narrative Mitochondria are essential for cell survival not only as sources of ATP but also as factors that control intracellular signaling. The role of mitochondrial generated ROS and signaling in regulating bone regeneration is currently unknown. This proposal seeks to identify the role of two novel mitochondrial related factors BNIP3 and NIX in regulating digit regeneration to elucidate mechanisms that can be targeted to enhance bone regeneration.

PI_NAMEs: GUNTUR, ANYONYA R (contact);SAMMARCO, MIMI C;TOWER, ROBERT

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Ambystoma;Amputation;BCL2/Adenovirus E1B 19kd Interacting Protein 3-Like;Bioenergetics;Biology;blastema;Bone Regeneration;Bone Tissue;Carbon;Cell Differentiation process;Cell Physiology;Cell Survival;Cells;Cellular Metabolic Process;Cues;Data;Development;digit regeneration;Digit structure;epithelial wound;Epithelium;Generations;genetic regulatory protein;Growth;Histology;Homeostasis;HRK gene;Immunofluorescence Immunologic;In Vitro;Injury;interest;Intervention;knock-down;Knockout Mice;Legal patent;limb regeneration;Link;Mammals;Maps;Mediating;member;Metabolic Control;mineralization;Mitochondria;Modeling;Mus;Musculoskeletal;Natural regeneration;novel;Organelles;Osteoblasts;Pathway interactions;Pattern;pharmacologic;Play;Process;Production;progenitor;Proteins;Reactive Inhibition;Reactive Oxygen Species;regeneration model;regenerative;Regenerative response;Regulation;response;Role;Signal Transduction;soft tissue;Source;Structure;Tadpoles;Testing;Transcript;transcriptomics;Transgenic Mice;Vertebrates;Zebrafish

PROJECT_TITLE: Mitochondrial function regulates ROS-mediated patterning following injury

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: The Centers for Disease Control and Prevention (CDC) designated Carbapenem-Resistant Acinetobacter baumannii (CRAb) an “urgent threat pathogen” for which novel therapies are desperately needed. To address this crisis, we propose to design novel inhibitors of the β-lactamases present in CRAb and discern how these inhibitors can gain better entry into the cell. As we determined that overexpressing certain β-lactamase genes (OXA -lactamases) creates unique cellular vulnerabilities by making certain gene products essential for survival, we will look for small molecules to inhibit those gene products.

PI_NAMEs: BONOMO, ROBERT A. (contact);RATHER, PHILIP N.

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acceleration;Acinetobacter baumannii;Active Sites;Address;amidase;Animal Testing;Antibiotics;Awareness;Bacteria;bacterial resistance;beta-Lactam Resistance;beta-Lactamase;Binding;Binding Sites;Boronic Acids;candidate identification;Carbapenem-resistant Acinetobacter;Categories;Cells;cellular targeting;Centers for Disease Control and Prevention (U.S.);Chemistry;Clinical;Collection;Color;COVID-19 pandemic;design;Drug resistance;Electronics;Enzymes;Exhibits;functional group;Funding;gene product;Genes;Genetic Variation;Goals;Healthcare;Healthcare Systems;high throughput screening;Hospitals;Hot Spot;Hydrolysis;Imipenem;improved;in vitro activity;Infection;inhibitor;insight;Intensive Care Units;interdisciplinary approach;Ions;Iron;iterative design;Kinetics;Lactamase;Lung infections;Mediating;Medical;Modification;Molecular;molecular modeling;Multienzyme Complexes;Nature;novel;novel strategies;novel therapeutics;Organism;overexpression;pathogen;Pathway interactions;Penetration;Peptidoglycan;Periodicity;periplasm;Pharmaceutical Chemistry;Pharmaceutical Preparations;Production;Property;Reaction;Resistance;scaffold;Serine;Side;small molecule;success;targeted treatment;VDAC1 gene;Zinc

PROJECT_TITLE: Understanding B-Lactam Resistance in Acinetobacter baumannii

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (90)]


NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE Mutations in the chromatin modifier ASH1L have been associated with autism spectrum disorders and epilepsy. ASH1L regulates large groups of genes simultaneously, including other genes that have been associated with autism and seizures such as FOXP1. We find that there are sex-specific differences in the presentation of the epilepsy and autism in patients with mutations in ASH1L. Our goals in this proposal are 1) clinically characterize patients with ASH1L mutations that variable degrees of phenotypic severity, and 2) identify the cellular defects and molecular signatures associated with ASH1L in stem cell experimental systems derived from a cohort of male and female patients with variable phenotypic severity.

PI_NAMEs: LIU, JUDY SHIH-HWA;LIZARRAGA, SOFIA BEATRIZ (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Address;Affect;Alternative Splicing;ASH1L gene;Attention deficit hyperactivity disorder;Attentional deficit;autism spectrum disorder;boys;Brain;Caring;Cells;Chromatin;Chromatin Remodeling Factor;Clinical;clinical phenotype;Clinical Research;Clinical Trials;cognitive function;cohort;Communities;Data;Defect;Deposition;Development;dimorphism;Disease;Environment;Epigenetic Process;Epilepsy;Evaluation;Family;Female;FOXP1 gene;Functional disorder;Future;Gene Expression;Gene Mutation;Genes;genetic risk factor;Genetic study;Genetic Transcription;genome-wide;Gilles de la Tourette syndrome;girls;Goals;high reward;high risk;histone methyltransferase;histone modification;Human;Human Genetics;Hyperactivity;improved;Individual;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Intellectual functioning disability;Intervention;Knowledge;Lead;Link;male;Medical;Molecular;molecular phenotype;Molecular Profiling;Mutation;Neurocognitive;Neurodevelopmental Disorder;Neurologic;neuron development;Neurons;neuropsychiatric disorder;Outcome;Patient Care;patient derived induced pluripotent stem cells;Patients;Persons;Phenotype;Physicians;Polycomb;Post-Translational Protein Processing;preclinical study;prenatal stress;Prevalence;Process;programs;Repressor Proteins;Research;response;risk variant;Schizophrenia;Seizures;Severities;sex;Sex Differences;specific biomarkers;stem cells;Structure;System;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;transcriptome;women patients;Work

PROJECT_TITLE: Uncovering sex-specific differences in ASH1L-disease

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative: Solid tumors are hard to treat with CAR T cells because the antigens they express are heterogenous. We propose the clinical translation of an approach that synergizes clinical imaging with T cell therapy to overcome the current limitations of toxicity, antigen loss variants and cost of engineered T cell therapy through the application of a bio-orthogonal image-enabled adaptable CAR (ImAC) method where CAR T cells can be tracked by imaging after infusion, and delivery of CAR T cells with tailored payloads can be monitored through noninvasive imaging. We will optimize the ImAC method in rigorous preclinical assays and then test feasibility, safety and response in a Phase I clinical trial for women with advanced ovarian cancer.

PI_NAMEs: FARWELL, MICHAEL DAVID;POWELL, DANIEL J. (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: adverse event monitoring;Affinity;Antibodies;Antibody-drug conjugates;Antigen Targeting;antigen-specific T cells;Antigens;antitumor effect;Antitumor Response;Ascites;Autologous;Binding;Biological;Biological Assay;Biological Products;cancer cell;Cancer Model;Cancer Patient;Cancer Remission;cancer therapy;CAR T cell therapy;Cell Therapy;Cells;cellular targeting;Cerebral Edema;Cessation of life;Chemistry;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical development;clinical imaging;clinical translation;combat;cost;Coupling;cytokine;Data;design;Diagnostic Imaging;Docking;Dose;Drug Delivery Systems;Engineered Gene;engineered T cells;Engraftment;experimental study;FDA approved;feasibility testing;first-in-human;folate-binding protein;Folic Acid;FOLR1 gene;Functional Imaging;gene therapy;Generations;Goals;Hand;Human;human cancer mouse model;Image;image guided;imaging probe;Immune;immune modulating agents;Immunity;Immunologic Receptors;immunopathology;improved;improved outcome;in vivo;in vivo imaging;Infusion procedures;Injections;Ligands;Macrophage;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Mediating;medication safety;Methods;molecular imaging;Monitor;multidisciplinary;Mus;non-invasive imaging;Normal tissue morphology;novel;Oncology;ovarian neoplasm;Patients;Peripheral;PET/CT scan;Phase;Phase I Clinical Trials;phase I trial;Phenotype;Physicians;Population;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;Prediction of Response to Therapy;Process;Protein Isoforms;Reagent;receptor;receptor binding;reconstitution;Recurrence;Research Personnel;response;Risk;Route;Safety;safety and feasibility;safety assessment;Schedule;Serous;Serum;small molecule;Solid;Solid Neoplasm;Specificity;synergism;synthetic biology;T cell therapy;T-Cell Receptor;T-Lymphocyte;targeted agent;targeted cancer therapy;Testing;theranostics;Therapeutic;Toxic effect;trafficking;translational approach;Translations;tumor;Tumor Antigens;tumor microenvironment;tumor specificity;Tumor-associated macrophages;tumor-immune system interactions;Variant;Woman;women's clinical trial;X-Ray Computed Tomography;Xenograft Model

PROJECT_TITLE: Dual-targeted DOTA CAR T cells with image-guided monitoring for solid tumor treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (J2)]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Lymphatic Research;Mental Health;Neurosciences;Pediatric;Prevention;Sleep Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Adolescents with type 1 diabetes (T1D) are at increased risk for problems with diabetes management and poor glycemic control. This randomized controlled trial will assess whether a behavioral intervention to improve sleep duration and quality will improve diabetes outcomes and executive function. We will also utilize advanced magnetic resonance imaging (MRI) methods in a subset of adolescents to understand mechanisms by which sleep duration affects brain health.

PI_NAMEs: JASER, SARAH SANDERS (contact);JORDAN, LORI CHAFFIN

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Adolescent;Adult;Affect;Age;Behavior;Behavior Therapy;Behavioral;behavioral sleep intervention;Blood Glucose;Blood Vessels;Brain;brain abnormalities;brain health;Caregivers;Cerebrospinal Fluid;Child;Childhood;Circadian Rhythms;clinical care;Clinical Research;Cognition;cognitive ability;cognitive function;COVID-19;Data;Development;diabetes management;Diabetes Mellitus;Diffusion Magnetic Resonance Imaging;Drainage procedure;efficacy testing;Endocrinologist;Equipment and supply inventories;executive function;Exhibits;experience;Family;fluid flow;Functional disorder;glycemic control;Glycosylated hemoglobin A;glymphatic clearance;glymphatic dysfunction;glymphatic flow;glymphatic system;high risk;Image;imaging modality;Impaired cognition;improved;improvement on sleep;Individual;Individual Differences;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Intercellular Fluid;Intervention;Leadership;Link;Liquid substance;Magnetic Resonance Imaging;Measures;meetings;Metabolic;modifiable risk;Motion;motivational enhancement therapy;multidisciplinary;Neurologist;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Outcome;Outcome Assessment;Pathway interactions;pilot trial;poor sleep;Population;Population Heterogeneity;programs;Proteins;psychoeducation;Psychologist;Questionnaires;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Recording of previous events;recruit;Risk;Risk Factors;Sampling;Self Assessment;Self Care;skills;Sleep;sleep behavior;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep quality;Structure;Surrogate Markers;Techniques;Teenagers;telephone session;Time;treatment as usual;United States National Institutes of Health;Waste Products;wasting;white matter;Work;Youth

PROJECT_TITLE: Sleep Promoting Intervention to Improve Diabetes Outcomes and Executive Function in Adolescents with T1D