ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: Boston

ORG_NAME: TUFTS UNIVERSITY MEDFORD

ORG_STATE: MA

PHR: RELEVANCE (See instructions): Stress is a major contributor to the development and maintenance of alcohol use disorder (AUD). Our preliminary data  in rats show that the neural mechanisms that signal alcohol’s aversive effects, which may serve to limit alcohol  drinking, are dysregulated following predator odor stress exposure. The proposed studies will elucidate the role of a  neural circuit in stress-induced tolerance to alcohol aversion and stress-induced escalation of alcohol self-administration in rats, and inform future research to identify novel targets for the prevention and treatment of AUD.

PI_NAMEs: WEERA, MARCUS MATTHIAS (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Acute;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol misuse;alcohol sensitivity;alcohol use disorder;Alcohols;Amygdaloid structure;Animal Model;Applications Grants;Area;Award;behavior test;Bobcat;Brain;career;career development;Cessation of life;coping;Data;data submission;Development;Dose;economic cost;Exhibits;experimental study;Exposure to;Faculty;Fiber;Foundations;Funding;Future;Genetic;genetic testing;Glutamates;Goals;Habenula;Heavy Drinking;Human;Hypothalamic structure;Immunohistochemistry;improved;in vivo;indexing;Individual;Individual Differences;Institution;Instruction;Investigation;Lateral;Maintenance;Measures;Mediating;Mediator;Mentors;neural circuit;Neurobiology;neuromechanism;Neurons;Neurosciences;new therapeutic target;novel;Odors;paired stimuli;Phase;Photometry;Positioning Attribute;Prevention;Principal Investigator;Procedures;programs;Psyche structure;Public Health;Publishing;Rattus;Research;research and development;response;Rewards;Role;Secure;Self Administration;Signal Transduction;skill acquisition;Stimulus;Stress;Stress and Coping;stress reactivity;Stressful Event;Techniques;tenure track;Testing;Training;Training Support;traumatic stress;Urine;Work

PROJECT_TITLE: Lateral Hypothalamus Circuits in Stress-Induced Blunting of Alcohol Aversion& Escalation of Alcohol Self-Administration

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: NARRATIVE People with disabilities, including those who are deaf and hard of hearing, are still vastly underrepresented in STEM graduate education programs, health science professions, and cancer research settings. The University of Rochester James P. Wilmot Cancer Institute, in partnership with the Rochester School for the Deaf, seeks to establish the Future Deaf Scientists program in Rochester, NY and nationwide to inspire, grow, and increase deaf student participation in STEM and cancer research fields. The FDS program is an inclusive mentored research education and training program that empowers deaf high school students to envision themselves as future STEM researchers capable of decreasing cancer disparities.

PI_NAMEs: HALL, WYATTE CHRISTOPHER;O'REGAN, RUTH  (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Address;American Sign Language;anti-cancer research;bilingualism;Biomedical Research;Cancer Center Support Grant;cancer health disparity;career;Communication Barriers;Communities;community engagement;Community Outreach;cultural competence;deaf;deaf students;Degree program;design;disability;Disabled Persons;Disparity;Drops;Education;education research;educational atmosphere;Educational Curriculum;Educational Models;Effectiveness;empowerment;Environment;Event;experience;Face;forging;Funding;Future;Graduate Degree;Graduate Education;hard of hearing;health literacy;Health Occupations;high school;High School Student;higher education;improved;Individual;innovation;Institution;Instruction;Learning Skill;Linguistics;Malignant Neoplasms;Mentors;National Cancer Institute;next generation;Outcome;Participant;Patient Self-Report;personalized approach;Population;posters;Program Effectiveness;Program Evaluation;programs;Publications;Recreation;Research;Research Personnel;Research Training;role model;Schools;Science;Scientist;Secondary Schools;Services;Site;skills;STEM career;STEM field;STEM research;STEM student;student participation;Students;summer institute;summer internship;Surveys;symposium;systemic barrier;Training;Training Programs;undergraduate student;United States National Institutes of Health;Universities

PROJECT_TITLE: Future Deaf Scientists Program at Wilmot Cancer Institute

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE- OVERALL While Delaware has high quality healthcare compared to other states, Delaware still has significant inequities in health and healthcare for non-White Delawareans; further, Delaware lags behind other states in a number of areas, including drug deaths, obesity, high preventable hospitalization rates, multiple chronic conditions and cancer. As such, the overarching goal for the continuation of the ACCEL CTR Program is to create a unified Delaware Clinical and Translational Research Community (inclusive of investigators and community members) that breaks down existing barriers, capitalizes on the unique strengths of its partners to establish infrastructure and accelerates the creation of equitable solutions that improve the health of all Delawareans and all Americans.

PI_NAMEs: HICKS, GREGORY E (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Acceleration;Adult;African American;Agreement;American;Area;Asian;Award;Biometry;Black race;Budgets;Caucasians;Cessation of life;Child Health;Childhood;Clinical;clinical infrastructure;Clinical Research;Communities;community engagement;Community Outreach;Delaware;design;Development;Epidemiology;Equity;Ethnic Origin;Evaluation;Funding;Goals;Grant;Growth;Health;health care quality;health equity;health inequalities;Health Promotion;Healthcare;Healthcare Systems;Hispanic;hospitalization rates;Hospitals;improved;Infrastructure;innovation;Institution;Intention;Investments;Learning;Letters;Malignant Neoplasms;member;Mission;Modeling;Modification;multiple chronic conditions;Native Americans;Obesity;Outreach Research;Pharmaceutical Preparations;Pilot Projects;Population;population health;Population Heterogeneity;Population Research;programs;racial diversity;Recommendation;recruit;Research Design;Research Personnel;Rural;Scientist;Societies;Structure;System;Time;Training;Translational Research;translational research program;translational scientist;Universities;Work;Writing

PROJECT_TITLE: Delaware Clinical and Translational Research ACCEL Program


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Estrogen;Women's Health Research

ORG_CITY: Columbus

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Resistance to endocrine therapy and recurrence are the leading causes of mortality in breast cancer patients. Prolyl hydroxylation (P4H) is an enzyme that hydroxylates proline into 4-hydroxyproline of collagens. This investigation will uncover a novel uncanonical role of P4HA1 in endocrine resistance by regulation ROS-ER stress pathway, and explore P4HA1 as a novel therapeutic target for endocrine resistant luminal breast cancer.

PI_NAMEs: XIONG, GAOFENG  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: 4-Hydroxy-Tamoxifen;acquired treatment resistance;Binding;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;cancer cell;Cells;Clinical;clinical practice;Collagen;combinatorial;Data;Disease Progression;Drug Combinations;Endocrine;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;Estrogen receptor positive;Estrogen Receptors;Estrogen Therapy;Estrogens;experimental study;Fulvestrant;Goals;hormone therapy;Hydroxylation;Hydroxyproline;in vivo;inhibitor;Investigation;knock-down;Malignant Breast Neoplasm;Malignant Neoplasms;Molecular;mortality;new therapeutic target;novel;overexpression;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Peptides;Proline;protein expression;Proteins;Reactive Oxygen Species;Recurrence;Regimen;Regulation;Relapse;Resistance;Role;Sampling;Selective Estrogen Receptor Modulators;Stress;Tamoxifen;Testing;Therapeutic;therapeutic target;therapy resistant;tumor;tumor growth;Xenograft Model

PROJECT_TITLE: Role of P4HA1 in Endocrine Resistance of Breast Cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: AIKEN

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT AIKEN

ORG_STATE: SC

PHR: One third of all human birth defects are associated with craniofacial malformation, such as cleft palate, suture closure defects, or lack of bone formation. We are using the zebrafish model to investigate the cellular and molecular mechanisms underlying development of cartilage and bone of the skull and jaw. By identifying the mechanisms producing normal craniofacial patterning in zebrafish we can investigate how disruption of these processes causes craniofacial diseases in humans.

PI_NAMEs: DELAURIER, APRIL F (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Animal Model;ATAC-seq;Biological Models;Biomedical Research;bone;Bone Growth;Bone structure;BRAF gene;Branchial arch structure;Bruck-de Lange syndrome;career;Cartilage;cartilage development;Cartilage Matrix;Cell Separation;Cells;cellular targeting;Cephalic;Chemicals;Chondrocytes;Chromatin;chromatin modification;Cleft Palate;cofactor;Communication;Complex;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial development;craniofacial structure;cranium;CRISPR/Cas technology;Critical Thinking;Data;Data Analyses;Defect;Development;Disease;disease model;Dissection;DNA Sequence Alteration;Educational Curriculum;Elements;Embryo;Environment;Enzymes;Epigenetic Process;Failure;Fetal Alcohol Syndrome;Future;Gene Abnormality;Gene Expression;Gene Modified;gene repression;Generations;Genes;Genetic;Genetic Transcription;Goals;Growth;HDAC1 gene;HDAC4 gene;HDAC8 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;In Situ Hybridization;Individual;inhibitor;Investigation;Jaw;KDM1A gene;loss of function;Medicine;Messenger RNA;migration;Modeling;Molecular;Molecular Target;mutant;Neural Crest;Neural Crest Cell;novel;Osteogenesis;Outcome;Pathway interactions;Pattern;Peer Review;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phenotype;prevent;Process;Production;protein complex;Publications;Regulation;Repression;Research;Research Design;reverse genetics;Role;Sampling;skeletal;Skeletal Development;Skeleton;skills;Specific qualifier value;Students;Surgical sutures;Syndrome;Techniques;Testing;Training;transcriptome sequencing;Transgenic Organisms;undergraduate research experience;undergraduate student;Work;Zebrafish

PROJECT_TITLE: Understanding the role of Hdacs in zebrafish craniofacial development

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (SF)]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Neurosciences

ORG_CITY: SPARTANBURG

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA

PHR: Project Narrative MicroRNAs (miRNAs) are critical regulators of gene expression and may be causative factors in disease development. This study will examine what genes are targeted by increased levels of an understudied miRNA- miR-718- and the relationship of these gene targets to changes in epigenetics in a human neuronal cell line.

PI_NAMEs: SHORTER, KIMBERLY R (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acetylation;Acute;Affect;angiogenesis;Apoptosis;Apoptotic;Autophagocytosis;Base Pairing;Binding;Biochemical;Biological Assay;Calcium Channel;Calcium Signaling;cancer cell;Cardiovascular Diseases;Cardiovascular Pathology;Cardiovascular system;Cell Line;Cells;CREB1 gene;Data;Databases;Dendritic Spines;Development;Disease;DNA;DNA Methylation;DNA methylation profiling;DNA Modification Methylases;DNA Sequence;Down-Regulation;ds-DNA;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;epigenetic regulation;Etiology;experience;Feedback;Flow Cytometry;Foundations;Future;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic Transcription;genome-wide;Health;Histone Acetylation;histone methylation;histone modification;Histones;Human;human subject;In Vitro;innovation;insight;interest;Knowledge;Laboratories;Life;Literature;Lysine;Maintenance;Malignant Neoplasms;Messenger RNA;methyl group;Methyl-CpG-Binding Protein 2;Methylation;Methyltransferase;MicroRNAs;Mitochondria;Modeling;Modification;Molecular;mRNA Expression;mRNA Transcript Degradation;Mus;Nervous System Disorder;Neurodevelopmental Disorder;Neurons;overexpression;Pathway interactions;Pattern;Perchlorates;Phosphorylation;Post-Transcriptional Regulation;Process;Production;promoter;Proteins;PTEN gene;Regulation;Regulator Genes;Research;Reverse Transcription;RNA;RNA Binding;RNA Interference;Role;Sampling;Small Interfering RNA;Stains;Synapses;System;Techniques;Tissues;transcription factor;transcriptome sequencing;Translating;Traumatic Brain Injury recovery;treatment group;undergraduate student;Untranslated RNA;Up-Regulation;Western Blotting;whole genome;Work

PROJECT_TITLE: In Vitro Identification of miR-718 targets and miR-718-induced epigenetic modifications


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CLEVELAND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative Our cells are constantly subjected to DNA damage, with single-stranded breaks (SSBs) being the most common form; fortunately, intricate mechanisms are in place to repair this damage. This research project focuses on unraveling how three essential DNA repair proteins (PARP1, LIG3, and PNKP) mend SSBs within nucleosomes, the physiologically relevant form of DNA. The insights gained through this study hold the potential to develop innovative treatments for cancer and neurological disorders, directly contributing to improved health outcomes.

PI_NAMEs: KIM, TAE HUN  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: ADP ribosylation;Base Excision Repairs;Biological Assay;biophysical tools;cancer therapy;Cells;Chromatin;Complex;Cryoelectron Microscopy;Detection;Disease;DNA;DNA Damage;DNA Library;DNA ligase III;DNA Ligases;DNA Repair;DNA Repair Gene;Drug Design;Enzymes;Family;Foundations;Genome Stability;Goals;Health;Histone Acetylation;histone modification;Histones;improved;innovation;inorganic phosphate;insight;Ligase;Malignant Neoplasms;Maps;member;Molecular;Mutation;Nervous System Disorder;next generation sequencing;Nucleosomes;Outcome;Pathway interactions;Phase;Phosphoric Monoester Hydrolases;Physiological;Play;Polynucleotide 5'-Hydroxyl-Kinase;Positioning Attribute;Process;Proteins;Radioactivity;recruit;repaired;Research;Research Project Grants;Role;Single Strand Break Repair;Site;Structure;Techniques;Therapeutic;Zinc Fingers

PROJECT_TITLE: Mechanistic Insights into Single-Strand Break Repair Within Chromatin

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


ADMINISTERING_IC: DK

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: NEW YORK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Brown adipose tissue in adult humans has been associated with reduced prevalence of type 2 diabetes and cardiovascular disease, suggesting that modulating brown fat function could result in significant public health benefits. Although we have developed an increasingly detailed understanding of environmental and biological determinants of brown fat function in humans, we know very little about its genetic determinants. The goal of this proposal is to identify genetic variants regulating brown fat function that are associated with metabolic phenotypes, determine whether predicted functional variants in brown fat genes regulate metabolic traits, and dissect the function of these variants in cellular models, offering the potential to identify new therapeutic targets.

PI_NAMEs: COHEN, PAUL  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Adipocytes;Adrenergic Agonists;Adult;African ancestry;Age;Animal Model;Area;bench to bedside;biobank;Biological;Biological Markers;Biology;Blood Glucose;Body mass index;Brown Fat;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cell model;Cerebrovascular Disorders;Clinical;clinical phenotype;Code;cohort;comorbidity;Congestive Heart Failure;Coronary Arteriosclerosis;Creativeness;Data;Data Set;Diabetes Mellitus;Diagnostic tests;Disease;Dyslipidemias;Energy Metabolism;FAT gene;Genes;Genetic;Genetic Determinism;genetic variant;genome editing;Genotype;Goals;Health;Health Benefit;Heterogeneity;Hispanic ancestry;Human;Human Biology;Human Genetics;Hypertension;improved;Individual;innovation;insight;Insulin Resistance;insulin sensitivity;Link;loss of function;Mammals;Measures;Metabolic;Metabolic Diseases;metabolic phenotype;Morbidity - disease rate;mortality;mouse model;multiple omics;natural hypothermia;new therapeutic target;Newborn Infant;Non-Insulin-Dependent Diabetes Mellitus;novel;obese person;Obesity;Outcome;Overweight;Patients;phenome;Phenotype;Population;Predisposition;Prevalence;Prospective Studies;Public Health;Regulation;Research;Resources;Role;Series;sex;System;Temperature;Testing;Thermogenesis;trait;Variant;virtual

PROJECT_TITLE: A Systems Approach for Elucidating Genetic Determinants of Human Brown Adipose Tissue Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-S (M3)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Natural killer (NK) cells play a key role in early control of multiple viral infections. Recent evidence from our group has shown that CD89, the IgA receptor, is expressed on a subset of NK cells particularly enriched in the mucosae. Further, unlike typical functions, this receptor may serve as checkpoint receptor for this cell population. This proposal is designed to explore the biology and therapeutic potential of this novel population. The outcome of these investigations will provide the rationale to further harness NK cells for vaccine design, curative or other therapeutic interventions against HIV.

PI_NAMEs: REEVES, ROGER KEITH (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Activities of Daily Living;Anatomy;Antibodies;antiretroviral therapy;Area;Autologous;B-Lymphocytes;Biology;CD3 Antigens;Cd68;Cells;checkpoint receptors;Clone Cells;cohort;Color;Cytometry;Cytotoxic T-Lymphocytes;Data;design;Disease Progression;Event;Exclusion;Gastrointestinal tract structure;Harvest;Helper-Inducer T-Lymphocyte;HIV;HIV Infections;Human;IgA receptor;Immune;immune function;Immunoglobulin A;Immunologics;Infection;Infection Control;Infusion procedures;Innate Immune System;innovation;interest;Intervention;Investigation;jejunum;Kinetics;Knowledge;Lentivirus Infections;Lymphoid Tissue;Macaca;Macaca mulatta;Measures;Mediating;mucosal site;Mucous Membrane;multiplexed imaging;Myeloid Cells;Natural Killer Cells;nonhuman primate;novel;novel therapeutic intervention;Outcome;Pathologic;peripheral blood;personalized medicine;Phenotype;Play;Population;prevent;preventive intervention;Public Health;Publishing;receptor;Receptor Cell;Regulation;Research;Role;Sampling;Signal Transduction;simian human immunodeficiency virus;Site;SIV;Stains;T-Lymphocyte;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;Vaccine Design;vaccine development;Viral Load result;Viral reservoir;Virus Diseases;Virus Replication

PROJECT_TITLE: Harnessing CD89+ NK Cells for Novel Therapeutic Interventions Against HIV/SIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-E (02)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Trichotillomania and excoriation disorder are disabling psychiatric conditions with limited effective treatments. This research uses a series of complementary neurogenomic investigations to significantly advance our understanding of the genes and neurodevelopmental pathways that contribute to these conditions. This is relevant to public health because it advances our fundamental knowledge of the underlying mechanisms that lead to trichotillomania and excoriation disorder, which has the potential to identify novel treatment targets to ultimately reduce the burden of these conditions.

PI_NAMEs: OLFSON, EMILY HUNT (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Area;Award;Biological;Brain;career;Child;Child Rearing;cohort;comparison control;Copy Number Polymorphism;Data;Development;Disabling;Disease;DNA Damage;DNA Sequence;DNA sequencing;effective therapy;Ensure;Excoriation;exome;First Degree Relative;gene network;Genes;Genetic;Genetic Risk;genetic variant;genome-wide;Genomics;Goals;Hair;improved;Individual;induced pluripotent stem cell;Inherited;Intervention;Investigation;Knowledge;Mentors;multidisciplinary;Mutation;neural;Neurobiology;neurogenetics;neurogenomics;neuropsychiatry;novel;Obsessive-Compulsive Disorder;Organoids;Parents;Pathway interactions;Patients;Pattern;pharmacologic;Physicians;programs;Public Health;Recurrence;repetitive behavior;Research;Research Personnel;risk variant;Role;Scientist;Series;sex;single-cell RNA sequencing;skills;Skin;success;Systems Analysis;Training;transcriptomics;Trichotillomania;Variant;Work

PROJECT_TITLE: Neurogenomic Investigations of Trichotillomania and Excoriation Disorder


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Skin Cancer

ORG_CITY: MURFREESBORO

ORG_DEPT: CHEMISTRY

ORG_NAME: MIDDLE TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: Relevance to Public Health. Metastatic melanoma is the deadliest of all skin cancers and new therapies are needed to treat primary and recurring diseases. The proposed project will identify novel FHP analogues that will be capable of overcoming clinical taxane resistance either as a single therapy or as an adjuvant to existing therapies with broad therapeutic utilities and desirable PK profile. The application will also provide new FHP analogues that are efficient against diverse cancer cell lines, including multidrug resistant sublines.

PI_NAMEs: BANERJEE, SOUVIK  (contact)

PROJECT_TERMS: Adjuvant;analog;angiogenesis;Antimitotic Agents;Apoptosis;Binding;Binding Sites;Biological Assay;Blood Vessels;BRAF gene;Cancer Biology;cancer cell;Cancer cell line;cancer therapy;Cell Line;Chemicals;Clinical;clinical efficacy;Clinical Trials;Colchicine;Complex;cytotoxicity;Data;design;Development;dimer;Disease;Disseminated Malignant Neoplasm;docetaxel;Dose;Dose Limiting;Drug resistance;drug-sensitive;Exhibits;Feedback;Generations;Hematopoietic;Human;Immune checkpoint inhibitor;improved;In Vitro;in vivo;indexing;Inhibition of Cell Proliferation;inhibitor;innovation;insight;Interdisciplinary Study;Laboratories;lead optimization;Malignant Breast Neoplasm;Malignant Neoplasms;Maximum Tolerated Dose;MEKs;melanocyte;Melanoma;Melanoma Cell;Metabolic;Metastatic Melanoma;Microtubules;Mitosis;Mitotic;Modification;molecular modeling;mouse model;Multi-Drug Resistance;multidrug resistant cancer;Mutation;neurotoxicity;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Paclitaxel;Patients;Pharmaceutical Preparations;polymerization;Polymers;Prognosis;Proliferating;Property;Public Health;Pyrazines;Pyrimidine;pyrimidine analog;Quinoxalines;Recurrence;Recurrent disease;refractory cancer;Research;Research Training;Resistance;Resolution;response;Roentgen Rays;Route;scaffold;screening;Series;Site;Skin Cancer;Structure;Structure-Activity Relationship;student training;success;Survival Rate;Synthesis Chemistry;taxane;Testing;Therapeutic;therapeutically effective;Toxic effect;Tubulin;tubulin polymerization inhibitor;tumor;tumor growth;water solubility;Work;Xenograft procedure

PROJECT_TITLE: Discovery of fused heterocyclic pyrazine based novel anti-mitotic agents for metastatic melanoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-7 (SF)]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_CITY: LAWRENCE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE Many basic biological processes depend on RNAs that must first adopt specific conformations. Our research will determine how the conformation of a critical RNA element located at the end of the hepatitis C virus genome changes when it interacts with other viral RNAs and how these conformational transitions control essential biological processes like viral replication and assembly. The insights made during this project will elucidate the fundamental biochemical mechanisms governing the function of this specific viral RNA element and contribute to a more comprehensive understanding of the functional capabilities of non-protein coding RNAs.

PI_NAMEs: HOLMSTROM, ERIK D (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Adopted;Amino Acids;Area;Behavior;Biochemical;Biological;Biological Process;Biology;Cessation of life;Chromatography;Code;conformational conversion;Cryoelectron Microscopy;Disease;effective therapy;Elements;Fluorescence Resonance Energy Transfer;Genetic;Hepatitis C virus;insight;Kinetics;Knowledge;Label;Lipids;Microscopy;Molecular Conformation;nano;Nucleosome Core Particle;Nucleotides;particle;Pathogenicity;physical model;Polyproteins;Process;Proteins;Regulation;Research;Research Project Grants;RNA;single molecule;Spectrum Analysis;Structure;Translations;treatment planning;United States;Untranslated RNA;Viral;Viral Genome;viral RNA;Virus;Virus Assembly;Virus Replication

PROJECT_TITLE: Uncovering the Biochemical Mechanisms of Riboregulatory Interaction Involving the Hepatitis C Virus 3'X RNA

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: R01 Project Narrative Dendritic cells are critical regulators of innate and adaptive immunity. By promoting their inherent tolerogenic functions in vivo using innovative approaches and technology, it may be possible to effectively regulate anti- donor immunity, extend graft survival and allow immunosuppressive drug withdrawal-achieve transplant tolerance.

PI_NAMEs: THOMSON, ANGUS W (contact)

PROGRAM_OFFICER_NAME: SHAW, JULIA M

PROJECT_TERMS: adaptive immunity;Address;Adoptive Transfer;Agonist;Alloantigen;Anti-Inflammatory Agents;Autologous;Biological Markers;Blood;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Clinical Trials;clinically relevant;Data;Dendritic Cells;drug withdrawal;extracellular vesicles;Family member;Funding;Generations;Goals;Graft Survival;Human;humanized mouse;Immune;Immunity;Immunoglobulins;immunoregulation;Immunosuppression;Immunosuppressive Agents;In Situ;in vivo;Infusion procedures;Innate Immune System;innovation;insight;kidney allograft;Kidney Transplantation;Leukocytes;Ligation;liver transplantation;Maintenance;Monoclonal Antibodies;mTOR Inhibitor;Mus;Myeloid Cells;nanobiologic;nanoparticle;National Institute of Allergy and Infectious Disease;Natural Immunity;nonhuman primate;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Organ Transplantation;Patients;Pharmaceutical Preparations;Physiologic pulse;post-transplant;predictive marker;prevent;programmed cell death ligand 1;programs;receptor;Regimen;Regulation;Regulatory T-Lymphocyte;Reporting;Research Design;Rhesus;Rodent;Sirolimus;T cell response;T-Lymphocyte;Technology;Testing;Therapeutic;Tissues;transplant model;Transplant Recipients;Transplantation;Transplantation Tolerance;Universities;Up-Regulation;Withdrawal;Work

PROJECT_TITLE: Innovative approaches to enhance regulatory myeloid cell function and renal transplant survival in nonhuman primates

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Narrative The study aims to develop advanced computational methods to understand how our genes affect our response to disease treatments. By applying cutting-edge techniques like deep learning, we hope to create personalized treatments for various complex diseases, such as cancer, autoimmune disorders, infectious diseases, and more. This research aligns with the NIH’s mission to advance disease treatment and has the potential to benefit many individuals in the future.

PI_NAMEs: CHIU, YU-CHIAO  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;advanced disease;Affect;Autoimmune Diseases;Award;Bioinformatics;Biological;Biology;Cells;Chemicals;Clinical;clinical investigation;Collaborations;Communicable Diseases;Communities;Complex;computer framework;Computing Methodologies;computing resources;cost effective;Data;data modalities;deep learning;deep learning model;Disease;disease model;Drug Interactions;drug repurposing;Education;empowerment;Engineering;Environment;evidence base;experience;Explosion;FAIR principles;follow-up;Future;Genes;Genetic;Genomics;Hematopoietic;Individual;Infrastructure;innovation;insight;Laboratories;large language model;Literature;machine learning model;Malignant Neoplasms;Mentors;Mission;Molecular;Molecular Mechanisms of Action;Multiomic Data;multiple omics;novel;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;personalized medicine;Pharmaceutical Preparations;Pharmacogenomics;Phenotype;Proteomics;Publishing;Research;Resources;response;Scientist;Techniques;Technology;Therapeutic Agents;therapeutic target;Time;tool;transcriptomics;Translational Research;Treatment Efficacy;treatment optimization;treatment strategy;United States National Institutes of Health;Virus Diseases

PROJECT_TITLE: Novel computational approaches for pharmacogenomics of complex diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-D (55)]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Dementia;Immunotherapy;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: GAINESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative/Public Health Relevance Lewy Body Dementia (LBD) is part of a spectrum of sporadic and hereditary neurodegenerative disorders called α-synucleinopathies (SPs) which includes Parkinson's disease (PD) and Parkinson's disease dementia, with no disease modifying interventions and in which progressive accumulation of intracellular inclusions of the misfolded protein α-synuclein (α-syn) into Lewy bodies in the nervous system is a characteristic feature. Investigators at the University of Florida have developed a novel molecular guided T cell therapy (MCT) that can target patho- logical α-syn, improving survival and behavior and reducing brain microstructural impairment in a preclinical mouse model. This research supplement will evaluate non-invasive and quantitative tracking of this novel therapy in an animal model of LBD using a new molecular imaging modality called magnetic particle imaging, providing a tool for mechanistic studies of MCT accumulation in the brain during LBD treatment.

PI_NAMEs: RINALDI-RAMOS, CARLOS M (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: adaptive immune response;Address;Administrative Supplement;Adoptive Cell Transfers;alpha synuclein;Alzheimer's Disease;Animal Model;Animals;Behavior;Biodistribution;Biological Assay;blood-brain barrier crossing;Brain;Brain region;cancer cell;cancer immunotherapy;cancer therapy;Cell Therapy;Cells;Central Nervous System;Characteristics;combat;Development;Diagnosis;Disease;Effectiveness;effectiveness outcome;Etiology;Euthanasia;Evaluation;Event;experience;Florida;Glioblastoma;Goals;Grant;Histology;Image;imaging modality;Immune;Immunotherapy;Impact evaluation;Impairment;improved;in vivo;Inherited;insight;Intervention;Label;Lewy Bodies;Lewy Body Dementia;Lewy Body Disease;Magnetic Resonance Imaging;Magnetism;Malignant Neoplasms;Manuscripts;Measures;Melanoma;misfolded protein;Modification;Molecular;molecular dynamics;molecular imaging;Monitor;mouse model;Mus;Mutation;nanoparticle;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;non-invasive imaging;novel;novel therapeutics;Outcome;Parents;Parkinson Disease;Parkinson's Dementia;particle;Pathologic;Pathology;Performance;pre-clinical;Pre-Clinical Model;pre-formed fibril;proteostasis;public health relevance;Publishing;quantitative imaging;Reporting;Research;Research Personnel;Research Support;responders and non-responders;Route;Safety;Signal Transduction;Site;Stratification;survival outcome;synucleinopathy;T cell therapy;T-Lymphocyte;targeted treatment;Techniques;Therapeutic;therapeutic effectiveness;Time;tool;Tracer;trafficking;tumor;United States National Institutes of Health;Universities;uptake;Work

PROJECT_TITLE: Magnetic Particle Imaging to Track T Cells in Molecular Guided T Cell Therapy for LBDs

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Contraception/Reproduction;Genetics

ORG_CITY: QUEENS

ORG_NAME: ST. JOHN'S UNIVERSITY

PHR: 1 This project explores how sperm development is regulated at the molecular and cellular level to 2 give the sperm proper morphology and fertilization competency. The findings from this project 3 will improve our understanding about the genetic regulation of cell differentiation in general. This 4 new knowledge will further help us understand the basic biology of certain causes of human 5 infertility and offer new insights into developing drugs to treat parasitic nematode infection.

PI_NAMEs: MEI, XUE  (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Affect;Alleles;Biological;Biology;Caenorhabditis elegans;Candidate Disease Gene;Cell Differentiation process;Cells;Competence;Data;Defect;Development;Drops;Fertility;Fertilization;Gene Expression;gene function;Genes;Genetic;genetic analysis;Genetic Transcription;genome sequencing;Germ Cells;Goals;Hermaphroditism;Human;improved;In Vitro;Infertility;insight;Integral Membrane Protein;Ions;Iron;Knock-out;Knowledge;male;male fertility;Maps;Meiosis;Molecular;Molecular Cloning;Morphology;Motility;Mutagenesis;mutant;Mutate;Mutation;Nematoda;Nematode infections;Organism;paralogous gene;Parasitic nematode;Partner in relationship;Pathway interactions;Peptide Hydrolases;Pharmaceutical Preparations;Phenotype;Phosphoric Monoester Hydrolases;Phosphotransferases;Point Mutation;Post-Translational Protein Processing;posttranscriptional;Process;Protein Biosynthesis;Protein phosphatase;Proteins;Regulation;Repression;Research;Role;screening;Signal Pathway;Signal Transduction;sperm cell;sperm function;Spermatids;Spermiogenesis;Sterility;System;temperature sensitive mutant;Testing;Tissue-Specific Gene Expression;whole genome;Work;Zinc

PROJECT_TITLE: Regulation of sperm activation in C. elegans


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BATON ROUGE

ORG_DEPT: PATHOLOGY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project Narrative Chronic inflammation and the resulting autoxidation of polyunsaturated fatty acids to lipid electrophiles form deleterious protein post-translational modifications and are major drivers of many human diseases. Our research program will use a model cell system, Staphylococcus aureus, to characterize polyunsaturated fatty acid autoxidation in cells, elucidate the molecular determinants of lipid electrophile formation, and identify the protein targets of lipid electrophiles. These studies will define the molecular interactions in cells that drive diseases associated with inflammation and validate targets for future therapies to treat and prevent these diseases.

PI_NAMEs: BEAVERS, WILLIAM NORRIS (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: adduct;Affinity;Affinity Chromatography;Amino Acids;Antioxidants;Back;Bacteria;Binding;Biological Models;Biological Process;Cardiovascular Diseases;Cell model;Cells;Characteristics;Chemistry;Chronic;Chronic Disease;Clinical Trials;Complex;cyclooxygenase 1;design;Diabetes Mellitus;Disease;Doctor of Philosophy;Enzymes;Failure;Future;Generations;Homeostasis;Human;Human body;human disease;Inflammation;Injury;Invaded;Lipids;Lipoxygenase;Malignant Neoplasms;Mammalian Cell;Maps;Mediating;Metabolic;Mitochondria;Mitochondrial Proteins;Molecular;Nerve Degeneration;oxidation;pathogen;Pathology;Pathway interactions;peroxidation;Polyunsaturated Fatty Acids;Post-Translational Protein Processing;Predisposition;prevent;Process;programs;Prostaglandin-Endoperoxide Synthase;protein function;Proteins;Proteomics;Reaction;Research;Role;Signal Transduction;small molecule;Source;Staphylococcus aureus;Structure;System;tissue repair;tool;Toxic effect;Validation

PROJECT_TITLE: Pathways of peroxidation: defining the autoxidation of polyunsaturated fatty acids and the cellular consequences

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_DEPT: PHARMACOLOGY

PHR: Telomere maintenance is essential for genome stability and the prevention of cancer and degenerative diseases. The proposed research will examine how environmental genotoxic and oxidative stress cause accelerated telomere shortening, and the pathways that preserve damaged telomeres. This project will reveal how various forms of telomeric DNA damage impact telomere function, cellular function and organism health.

PI_NAMEs: OPRESKO, PATRICIA L (contact)

PROGRAM_OFFICER_NAME: HEACOCK, MICHELLE

PROJECT_TERMS: Acceleration;Animal Model;Award;base;cancer cell;cancer prevention;carcinogenesis;Cell Culture Techniques;Cell Physiology;Cell Proliferation;cell type;Cells;Chromosomes;Chronic;Degenerative Disorder;DNA Damage;DNA lesion;Environment;Excision Repair;experimental study;flexibility;Functional disorder;Funding;Generations;Genetic;Genome Stability;Genotoxic Stress;Goals;Guanine;Health;Human;human tissue;innovation;Knowledge;Learning;Lesion;Maintenance;Measures;model organism;Mus;National Institute of Environmental Health Sciences;nucleobase;Organ;Organism;Outcome;Oxidative Stress;parent grant;Pathway interactions;Phase;Phenotype;Population;preservation;programs;Proliferating;Proteins;repaired;Research;System;Technology;telomere;telomere damage;telomere loss;Telomere Maintenance;Telomere Shortening;tool;Transgenic Organisms;Translating;Work;Zebrafish

PROJECT_TITLE: Supplement to Promote Diversity


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Dental, Oral, and Craniofacial Disease;Headaches;Migraine;Neurosciences;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative The chronic comorbidity of migraine and temporomandibular disorders is a significant, but overlooked, public health concern. Its underlying molecular mechanisms are not well understood, and there is a lack of evidence- based treatment approaches. Using a multidisciplinary approach our studies are anticipated to validate S1PR1 as a novel target, with FDA-approved functional S1PR1 antagonists as a unique monotherapy approach, for therapeutic intervention in this chronic comorbidity.

PI_NAMEs: AKERMAN, SIMON  (contact);ROMERO-REYES, MARCELA ;SALVEMINI, DANIELA

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Agonist;Animal Model;antagonist;Astrocytes;Attenuated;Behavioral;Biochemical;Biochemistry;Chronic;clinical translation;comorbidity;Coupled;Data;Development;disability;Disease;disease model;Dose;Electrophysiology (science);Evidence based treatment;experience;Family;FDA approved;Female;field study;Gene Expression;Genetic;genetic approach;Immunohistochemistry;in vivo;Inflammasome;Inflammation;Inflammatory;insight;interdisciplinary approach;Interleukin-1;Intervention;Investigation;Knowledge;Laboratories;Ligands;Link;male;marenostrin;Mass Spectrum Analysis;Measures;Mediating;Migraine;Modeling;Molecular;molecular targeted therapies;multiple sclerosis treatment;neurobiological mechanism;Neuroglia;neuroinflammation;Neurons;new therapeutic target;Nociception;non-opioid analgesic;novel;Outcome;Pain;Pain Disorder;pain model;pain outcome;painful neuropathy;Pathway interactions;patient population;Patients;Performance;pharmacologic;Pharmacologic Actions;Pharmacology;Pilot Projects;Population;Positioning Attribute;pre-clinical;Pre-Clinical Model;preclinical development;Prevalence;prevent;Preventive;Process;Production;Proteomics;Protocols documentation;Public Health;Publishing;receptor;Reporting;response;Risk;Rodent;Role;Safety;Serum;Severities;Signal Pathway;Signal Transduction;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Spinal;Symptoms;targeted treatment;Temporomandibular joint disorder pain;Temporomandibular Joint Disorders;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy outcome;Time;TMD treatment;topiramate;Translating;Treatment outcome;treatment strategy;Trigeminal Nuclei;Trigeminal Pain;Trigeminal System;Validation;Work

PROJECT_TITLE: Molecular basis for functional S1PR1 antagonists in the treatment of comorbid migraine and temporomandibular disorders

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Primary Health Care

PHR: PROJECT NARRATIVE The use of medications with risk of harm is prevalent among persons with Alzheimer’s disease and related dementias (ADRD) during post-acute care transitions, and associated with dire consequences; yet multiple barriers exist that make it difficult to deprescribe these medications in this population. This proposed study aims to use the mixed methods approach to develop a home-based intervention to improve deprescribing of risky medications for older adults with ADRD during post-acute care transitions that is based on existing services and resources in home health care. Study results and training from this K76 application will result in a potentially sustainable deprescribing intervention based in home health care services, which can improve medication safety and health outcomes of older adults with ADRD during post-acute care transitions and beyond.

PI_NAMEs: WANG, JINJIAO  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acceleration;acceptability and feasibility;Acute;acute care;Address;Adopted;Advocacy;Alzheimer's disease care;Alzheimer's disease patient;Alzheimer's disease related dementia;Antipsychotic Agents;arm;Award;care coordination;Caregiver support;Caregivers;Caring;Cessation of life;Clinical;clinical practice;Clinical Trials;Communication;Communities;comorbidity;Complex;concept mapping;Conduct Clinical Trials;Confidence Intervals;Data;Data Analyses;Data Set;Dementia;dementia care;design;Development;Diagnosis;Discipline of Nursing;Doctor of Philosophy;Dose;Drug Prescriptions;Education;effectiveness testing;Elderly;Enrollment;Environment;experience;feasibility testing;Feedback;follow-up;Foundations;functional decline;Funding;General Population;Gerontology;Goals;Health;health care delivery;health care service;health care service utilization;Health Services for the Aged;Healthcare;Home;Home Care Services;Hospitalization;Impaired cognition;improved;indexing;innovation;Inpatients;Institutionalization;Intervention;intervention effect;intervention refinement;Interview;Knowledge;leadership development;Link;Long-Term Care;Medicare claim;medication safety;Medicine;Mentors;Methods;Monitor;multidisciplinary;multiple chronic conditions;novel;older adult;older patient;Older Population;Outcome;patient safety;Patients;Persons;Pharmaceutical Preparations;Pharmacy facility;Polypharmacy;Population;post intervention;Prevalence;primary care provider;Process;professor;programs;Provider;Psychiatry;Psychology;Quality of life;Recommendation;Registered nurse;Research;Research Personnel;Resources;Risk;Role;routine practice;Sampling;School Nursing;Services;skills;Symptoms;Syndrome;System;Training;trend;Universities;Work

PROJECT_TITLE: Deprescribing for Post-Acute Care Older Patients with Dementia in Home Health Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-6 (M1)]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Digestive Diseases;Immunotherapy;Inflammatory Bowel Disease;Microbiome

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Immune checkpoint inhibitor blockade (ICB) with monoclonal antibodies against CTLA-4 and PD-1, is widely used to promote anti-tumor immune responses in a range of human cancers but can also lead to inflammatory toxicities. Colitis is a common and severe type of adverse which can lead to treatment discontinuation. Using a newly developed model of ICB-induced colitis, we propose studies to understand how the microbiota and intestinal immune cells trigger colitis after ICB.

PI_NAMEs: NUNEZ, GABRIEL  (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Animal Model;anti-CTLA4;anti-CTLA4 antibodies;anti-tumor immune response;Antibodies;Antigens;Antitumor Response;Applications Grants;Automobile Driving;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;Cells;Colitis;Colon;Critical Pathways;CTLA4 blockade;CTLA4 gene;cytotoxic;Dendritic Cells;Development;Fc domain;Gene Targeting;Generations;germ free condition;gut inflammation;Human;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune Targeting;immune-related adverse events;Immunological Models;Immunologics;in vivo;Inflammatory;inhibitor;integrin alpha4beta7;Intervention;Intestines;Laboratory mice;Lymphocyte;Malignant Neoplasms;Melanoma patient;member;Microbe;microbiome;microbiota;Monoclonal Antibodies;Mus;nanobodies;neutrophil;Pathogenicity;Patients;PD-1 blockade;PD-1 inhibitors;Peripheral;Population;programmed cell death ligand 1;programmed cell death protein 1;Receptor Signaling;reconstitution;Regulation;Regulatory T-Lymphocyte;Resistance;Role;Signal Pathway;symbiont;T-Lymphocyte;Testing;Tissues;Toxic effect;Transgenic Mice;tumor

PROJECT_TITLE: Microbiota-Immune Interactions in CTLA-4 Antibody Blockade-Induced Colitis

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_DEPT: GENETICS

PHR: Project Narrative By exchanging genetic variants between populations, admixture has profoundly shaped human population history, courses of natural selection, and phenotypes and disease burdens across populations. Failure to consider admixture or the use of wrong models can lead to major adverse consequences in biomedical applications. This research combines analytical, computational, and experimental approaches, and will generate novel insight into the evolutionary and functional consequences of admixture, improve our knowledge of complex traits etiology, and inform strategies to help reduce health disparity in admixed, underserved populations.

PI_NAMEs: ZHANG, XINJUN  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Acceleration;Admixture;adverse outcome;biobank;Biological;burden of illness;Complex;Computing Methodologies;Drosophila genus;East Asian;Etiology;Event;Evolution;experience;Failure;fitness;Generations;Genes;Genetic;genetic architecture;genetic variant;Genetic Variation;Genome;genomic data;Genomics;Health;Human;Human Genetics;improved;Individual;insight;Knowledge;Macaca mulatta;machine learning method;method development;Modeling;Modernization;Natural Selections;novel;Phenotype;phenotypic data;Population;Process;Recording of previous events;Records;Reduce health disparities;Research;Shapes;simulation;South American;Statistical Methods;System;Time;tool;trait;Underserved Population;Work

PROJECT_TITLE: Deciphering The Evolutionary and Biological Impact of Human Admixture

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Aging;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Nutrition;Obesity;Prevention;Wound Healing and Care

ORG_CITY: ROCHESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: ROCHESTER INSTITUTE OF TECHNOLOGY

PHR: Project Narratives  Obesity is a risk factor for several diseases, two of which are diabetes and chronic wounds:  85% of adults Americans with type 2 diabetes mellitus (T2DM) are overweight or obese,  and 30% of obese adults have the disease.  The overall premises of this proposal is to develop a predictive mathematical model of  obesity-induced diabetic chronic wound that focuses on better understanding the role of  major glucose/glycogen exchange factors, which were previously represented by constant  parameters, by modeling them with variable functions.  This project offers a potential to reinvent the modeling of glucose-insulin dynamical sys-  tem in obesity-induced diabetic chronic wound by enhancing the quality of virtual patients  development, necessary for assessing new experimental or approved drugs.

PI_NAMEs: SIEWE, NOURRIDINE  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Adult;adult obesity;Affect;American;Area;Blood;Blood Glucose;Body Weight decreased;Calibration;Cells;chronic infection;chronic wound;Clinical Trials;Cutaneous;cytokine;Data;design;Development;Diabetes Mellitus;diabetic;Diabetic Foot Ulcer;diabetic patient;diabetic wound healing;Diet;Dietary Intervention;dieting;Differential Equation;Diphosphates;Discipline;Disease;dynamic system;efficacy evaluation;Endothelial Cells;Fasting;feeding;Foundations;Future;Glucagon;Gluconeogenesis;Glucose;glucose 1 phosphate;Glucose Plasma Concentration;glucose transport;glucose uptake;Glucose-6-Phosphate;Glycogen;glycogen metabolism;Guanine Nucleotide Exchange Factors;Habits;Health;Hepatitis B Virus;High Prevalence;Hour;Human;human old age (65+);Impaired healing;improved;in silico;Injections;innovation;Insulin;Insulin Resistance;insulin signaling;invention;Isomerism;Knowledge;Lead;lipid mediator;Literature;Liver;Malignant Neoplasms;mathematical model;Metformin;Methods;Modeling;Muscle Contraction;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity management;Osteoporosis;Overweight;Pathogenesis;Patients;Pharmaceutical Preparations;Physiological;Prediabetes syndrome;predictive modeling;Process;Production;Radial;Reaction;Research;Risk Factors;Role;Series;Signal Pathway;Skin wound healing;SLC2A1 gene;Stromal Cell-Derived Factor 1;success;System;Techniques;Time;tool;Translating;Type 2 diabetic;type I and type II diabetes;Uridine;Vascularization;virtual;virtual human;virtual patient;Work;wound closure;wound healing

PROJECT_TITLE: Mathematical Models for Obesity-Induced Type 2 Diabetes Mellitus and Chronic Wound Healing


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Human disease is inherently heterogenous, and every cell in a person’s body has a different protein expression, presentation of antigens, and structural environment. The proposed research aims to develop microscopy techniques that will allow us to reconstruct not only the three-dimensional structural network of cells and tissues in biological material such as tumors, but also the 3D variation in molecular expression, simultaneously. Such techniques will ultimately allow us to determine how cells and tissue work, or fail to work, cooperatively in the progression of diseases such as cancer and identify new opportunities for treatment.

PI_NAMEs: KING, SARAH BAILEY (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;absorption;Antigen Presentation;Biocompatible Materials;Biological;biological research;Biology;Cancer Biology;Cells;cellular imaging;Color;Development;Disease;Disease Progression;Electron Microscopy;Environment;Fibroblasts;fluorescence imaging;Functional Imaging;Genotype;Heterogeneity;high resolution imaging;human disease;Image;imaging modality;Infrastructure;Label;light microscopy;Location;Malignant Neoplasms;Microscopy;Molecular;molecular imaging;nanoscale;Optics;Pancreas;Persons;photoemission;programs;protein expression;Proteins;receptor;Research;Resolution;Specificity;structural imaging;Techniques;Tissue Sample;Tissues;treatment strategy;tumor;tumor metabolism;Variant;Visualization;Work

PROJECT_TITLE: Realizing BRAVE-EM for Nanoscale Multicolor Imaging in Biology: Biological Real-space Absorption Visualization by photoEmission Electron Microscopy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-F (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Dementia;Dissemination and Implementation Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE  Preventive care with delayed benefits and short-term harms, such as breast cancer screening, may be unnecessary or inappropriate in older adults with AD/ADRD. This project aims to examine the perspectives of older women with AD/ADRD and their caregivers on how they respond to messaging on breast cancer over- screening and make decisions about de-implementation. The results will enhance the generalizability of messaging strategies for reducing breast cancer over-screening from the parent R01 and inform new interventions to de-implement unnecessary or inappropriate care in older adults with AD/ADRD.

PI_NAMEs: SCHOENBORN, NANCY  (contact)

PROJECT_TERMS: Administrative Supplement;Adult;Advocacy;Affect;Alzheimer's disease related dementia;Attitude;Behavioral;Belief;Breast Cancer Detection;Caregivers;Caring;Case Study;Clinical;Clinical Treatment;Cognitive;Communication;Communities;Data;Data Collection;Decision Making;Deimplementation;Dementia;Development;Diagnosis;Ensure;Feedback;Future;General Population;Health Professional;Health system;human old age (65+);insight;Intervention;Interview;Language;Life;Life Expectancy;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Maryland;Morbidity - disease rate;mortality;neuropsychiatric symptom;novel;older adult;older women;overtreatment;parent grant;parent project;Parents;Patients;preference;Preventive care;Process;psychological distress;recruit;response;routine screening;screening;Screening for cancer;Severities;support tools;Surveys;synergism;Testing;Training;Woman

PROJECT_TITLE: Messaging Strategies to Reduce Breast Cancer Over-Screening in Older Women

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PHR: PROJECT NARRATIVE Understanding the genomic basis of traits that affect survival and reproduction is of great importance to understanding human health and disease. Our proposal leverages tissue-specific assays of gene regulation, field collections, and the integration of predictive models for sequence data with population/quantitative genetic approaches to address the fundamental challenge of connecting genotype to phenotype in the premier biomedical mammalian model system (house mice). In doing so, we will address fundamental questions on the evolution of gene regulation and complex traits.

PI_NAMEs: MACK, KATYA  (contact)

PROJECT_TERMS: Address;Affect;Alleles;Behavior;Biological Assay;Biological Models;Biology;Blood Chemical Analysis;Chromatin;Collection;Complex;Data;Disease;Environment;Evolution;fitness;gene environment interaction;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;genetic approach;genetic variant;Genetic Variation;Genome;Genomics;Genotype;Goals;Health;House mice;Human;human disease;Human Genetics;Kidney;Link;Measures;Phenotype;Physiology;Play;Population;predictive modeling;Process;Quantitative Genetics;reconstruction;Reproduction;Role;Scanning;single-cell RNA sequencing;Surveys;Testing;Tissues;trait;Untranslated RNA;Variant;variant detection;Work

PROJECT_TITLE: Gene regulation and the genetic basis of complex traits


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Nanotechnology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: CLEVELAND STATE UNIVERSITY

PHR: Project Narrative This R03 project aims to establish the foundation for developing an extracellular vesicle (EV)-based therapy for treating critical Volumetric Loss Defects (VML) injuries caused by traumatic incidents such as road accidents, major falls, or fire breakouts. Specifically, in this project, we will develop a new class of customizable therapeutic EVs by controlled pre-conditioning of parent cells and understand the role of the therapeutic EVs in influencing myogenesis towards healthy muscle formation. The results of this pilot project will set the basis for future elaborate studies that will introduce a full-proof EV-based regenerative medicine therapy for treating patients with critical VML injuries or other injuries that require muscle regeneration.

PI_NAMEs: SIKDER, PRABAHA  (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Accidents;Adipose tissue;Affect;Allografting;Amputation;Biogenesis;Biological Assay;Biological Process;Biomedical Engineering;Cell Therapy;Cells;Chronic;Collaborations;Complication;Defect;design;Development;Dimensions;efficacy evaluation;Engineering;Exhibits;exosome;experience;extracellular vesicles;falls;Fibrosis;Fire - disasters;fire fighter;follow-up;Foundations;Future;Genes;Goals;healing;Immune;Immunohistochemistry;Impairment;infection rate;Inflammation;Injury;insight;Life;Lifelong disability;Limb structure;Mediating;medical schools;Medicine;Mesenchymal Stem Cells;MicroRNAs;Morbidity - disease rate;Morphology;Muscle;Muscle Cells;muscle regeneration;Musculoskeletal;musculoskeletal injury;myogenesis;nano;nanoparticle;Ontology;Operative Surgical Procedures;Outcome;Pain;Parents;Pathway interactions;Patients;Physical therapy;Pilot Projects;Positioning Attribute;preconditioning;primary outcome;Quantitative Reverse Transcriptase PCR;Regenerative Medicine;Research;Role;scaffold;severe burns;Signal Pathway;Site;Skeletal Muscle;Small RNA;Sports;standard of care;Symptoms;Testing;Therapeutic;therapeutic development;Tissue Engineering;tissue regeneration;transcriptome sequencing;Transfection;Transmission Electron Microscopy;Transplantation Surgery;Trauma;Treatment Efficacy;Universities;volumetric muscle loss;Western Blotting

PROJECT_TITLE: Bioengineering of Customized Exosomes as a Cell-free Therapy for Volumetric Muscle Loss Injuries Proposal

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Our primary objective is to elucidate the intricate regulatory mechanisms through which membrane lipids and cell signaling pathways modulate voltage sensing of ion channels. By using state-of-the-art techniques, notably patch-clamp fluorescence lifetime imaging (FLIM) and Förster resonance energy transfer (FRET), the proposed experiments will yield comprehensive mechanistic insights. These insights have the capacity to unravel novel therapeutic avenues for addressing disease conditions.

PI_NAMEs: DAI, GUCAN  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Address;Amino Acids;biophysical techniques;Cardiac;Chemistry;Cholesterol;Coupling;cyclic-nucleotide gated ion channels;Dimensions;Disease;Environment;Exercise;experimental study;Fluorescence;fluorescence lifetime imaging;Fluorescence Resonance Energy Transfer;Fluorometry;Genetic Code;Goals;improved;inflammatory pain;insight;Investigation;Ion Channel;Ion Channel Gating;Label;Laboratories;Lipids;Measurement;Measures;Membrane;Membrane Lipids;Molecular Conformation;Mutation;nano;neuronal excitability;Neurons;novel therapeutics;Pacemakers;painful neuropathy;patch clamp;Physiological Processes;Play;Proteins;Regulation;Role;sensor;Signal Pathway;Signal Transduction;Site;somatosensory;Spinal Ganglia;Techniques;Transition Elements;virtual;voltage

PROJECT_TITLE: VOLTAGE-SENSING MECHANISMS OF ION CHANNELS IN DYNAMIC LIPID MEMBRANES


NIH_SPENDING_CATS: Diabetes

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative In Type 2 diabetes (T2D), the loss of controlled release of the hormone, insulin, by pancreatic islet β-cells is well-defined as a key event in the transition from insulin resistance to frank diabetes. The molecular mechanisms underlying these defects are not completely understood yet could have considerable therapeutic value if islet β-cell function could be restored. Our studies will use sophisticated imaging techniques to explore how metabolic changes in glucose sensing lead to defects in insulin production in the development of T2D.

PI_NAMEs: STEPHENS, SAMUEL BRANDON (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Address;Beta Cell;Buffers;Cell model;Cell Physiology;controlled release;Coupled;Data;Defect;defined contribution;design;Development;Diabetes Mellitus;Diet;disulfide bond;Disulfides;Endoplasmic Reticulum;endoplasmic reticulum stress;Environment;Equilibrium;Event;exhaustion;Exocytosis;Failure;functional decline;Functional disorder;Generations;Genetic;Glucose;glucose metabolism;Glutathione;Goals;Homeostasis;Hormones;Human;Imaging Techniques;Impairment;Insulin;insulin granule;Insulin Resistance;islet;Islets of Langerhans;Knock-in;Lead;Link;Mediator;Metabolic;Metabolic Control;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;mouse model;Mus;Mutation;NADP;Non-Insulin-Dependent Diabetes Mellitus;non-Native;novel;Organelles;Oxidation-Reduction;Pathway interactions;pharmacologic;prevent;Production;Proinsulin;Protein Disulfide Isomerase;Regulation;Reporter;Reporting;restoration;Rodent;Role;Secretory Cell;Secretory Vesicles;System;Testing;Therapeutic;trafficking;TXN gene

PROJECT_TITLE: Metabolic control of beta-cell secretory organelle function

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Perturbations of the intercellular signaling systems that control organ growth are a major source of human disease, associated with a wide range of developmental, physiological disorders as well as most forms of cancer. The proposed research is relevant to public health because solving how such systems normally function to direct as well as terminate growth as organs develop is essential for the development of more effective diagnostic and therapeutic treatments for this enormously broad range of afflictions. Thus, the proposed research is relevant to NIH's mission to reduce the burden to society arising from genetic and environmental disorders of fundamental aspects of human development and physiology.

PI_NAMEs: STRUHL, GARY  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Animals;Body part;Bone Morphogenetic Proteins;Cells;Complement;Complex;Development;Diagnostic;Dimerization;Disease;Drosophila frizzled protein;Drosophila genus;Family;Fatty acid glycerol esters;fly;G-Protein-Coupled Receptors;Gene Expression;Gene Structure;Genes;Genetic;Genetic Enhancer Element;Goals;Growth;Health;Human;Human Development;human disease;insight;Leg;Logic;Malignant Neoplasms;man;member;Mission;Modeling;Molecular;morphogens;Organ;organ growth;Pattern;Physiological;Physiology;Porifera;programs;Protein Secretion;Proteins;Public Health;receptor;recruit;Research;response;Role;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;Societies;Source;System;Testing;Therapeutic;Tissues;tool;transcription factor;Transgenic Organisms;United States National Institutes of Health;Wing;Work

PROJECT_TITLE: Morphogen control of organ growth in Drosophila

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_CITY: BETHESDA

ORG_NAME: U.S. NATIONAL INST/CHILD HLTH/HUMAN DEV

PHR: PROJECT NARRATIVE Phenotypic heterogeneity is a process that allows populations of genetically identically bacteria to form behaviorally distinct sub-populations, such as antibiotic tolerant persister cells. Small RNAs (sRNAs) form regulatory feedback loops associated with many heterogeneously expressed processes. This proposal aims to examine how sRNAs contribute to phenotypic heterogeneity in bacteria and how sRNAs themselves are expressed across individual bacteria in a population.

PI_NAMEs: ZHU, DENNIS  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Amyloid fibers;Anabolism;anti-microbial tolerance;antibiotic tolerance;Antigens;antimicrobial;Bacteria;Behavior;Behavioral;behavioral phenotyping;Binding;Cells;combat;cost;Data;Development;Drug resistance;Environment;environmental change;Escherichia coli;extracellular;Feedback;Fiber;Filament;Flagella;Flagellin;Flow Cytometry;Fluorescent in Situ Hybridization;Gene Expression;Genes;Genetic Transcription;Growth;Heterogeneity;Immune;Immune Evasion;Individual;Infection;Investigation;Kinetics;Link;Liquid substance;Measurement;Measures;Mediating;Messenger RNA;Metabolism;Methodology;Microbial Biofilms;Modality;Molecular;Monitor;Motility;mutant;Noise;Outcome;pathogenic bacteria;Pathway interactions;Pattern;Phase;Phenotype;Physiologic pulse;Population;Post-Transcriptional Regulation;Process;Processed Genes;promoter;Proteins;Regulation;Regulatory Pathway;Reporter;Research;Research Proposals;RNA;Role;Sampling;Series;single-cell RNA sequencing;Small RNA;Structure;Surface;Testing;Time;transcription factor;Translational Repression;Translations

PROJECT_TITLE: Investigation of small RNA expression in single cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-B (MK)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Human Genome;Infectious Diseases;Regenerative Medicine

ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE The next generation of human health improvements and medical advances will continue to be driven by the ability to use cells as therapeutics. Current strategies to utilize cell-based therapeutics have made remarkable progress but remain limited in terms of persistent efficacy and patient safety in large part because they rely upon disruption of our native genetic code. This project will enable innovative new ways to safely and effectively repurpose human cells as customizable medicines without alterations to the human genome to ultimately prevent and better treat a wide range of human ailments.

PI_NAMEs: HILTON, ISAAC  (contact)

PROJECT_TERMS: Adopted;Adverse event;Area;Award;base editing;Biological Process;Biotechnology;Cell Physiology;Cell Therapy;cell type;Cells;cellular engineering;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;cost;CRISPR/Cas technology;cytotoxic;cytotoxicity;Dependence;Development;DNA;DNA Viruses;Double Stranded DNA Virus;Elements;empowerment;Engineering;Ensure;epigenetic silencing;epigenome;Episome;Exhibits;experience;extrachromosomal DNA;Foundations;Funding;Gene Expression Profile;gene product;gene therapy;Gene Transduction Agent;Genetic;Genetic Code;genetic payload;genetic technology;Genetic Transcription;Genome;genome editing;Genomics;Goals;hazard;Health;Herpes Simplex Infections;Human;Human Engineering;Human Genome;improved;innovation;Integrase;Interleukin-10;Interleukin-2;Medical;Medicine;Methods;Mission;Modality;Mus;National Institute of Biomedical Imaging and Bioengineering;Neurons;next generation;Outcome;Output;Pathologic;patient safety;Patients;prevent;prime editing;Process;programs;promoter;Property;Reporter Genes;Research;Research Personnel;response;Safety;scaffold;Shapes;Site;small molecule;synergism;synthetic biology;System;Technology;technology platform;Therapeutic;therapeutic gene;Time;tool;transcription factor;transcriptome;transduction efficiency;transgene expression;Transgenic Organisms;Transposase;United States National Institutes of Health;Validation;vector;Viral;Viral Vector;Virus;Virus Integration;Work

PROJECT_TITLE: Engineering therapeutic cellular functions using robust and highly programmable extrachromosomal genetic technologies

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative (Supplement) This supplement aims to bring Kylie Wright, who is underrepresented (i.e., disabilities, first generation of college, low socioeconomic status, female in neuroscience) in the sciences, our institution, and the U.S., to work under the parent grant (R01AG072658). This project offers an ideal context for Kylie's research and career development, given her future career goals to complete a postdoctoral fellowship and become an independently funded academic scholar on neurobiological and physiological changes underlying decision making in aging/ADRD. Working towards all three parent grant aims, Kylie will have the opportunity to (i) acquire a strong conceptual background in aging/ADRD and decision neuroscience; (ii) gain invaluable hands-on experiences in advanced statistical analysis of behavioral, physiological, and neuroimaging data; and (iii) enhance her academic writing and scientific communication skills via completion of her dissertation and publications/presentations.

PI_NAMEs: EBNER, NATALIE C (contact);LIGHTHALL, NICHOLE ;WILSON, ROBERT C

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: age related;Aging;Alzheimer's disease related dementia;Anterior;Awareness;Behavioral;Brain;career;career development;Clinical;Cognitive;college;Communication;Cues;Data;Data Analyses;Decision Making;Development;disability;Disabled Persons;distrust;Emotional;Emotions;experience;Face;Fellowship;Female;Fostering;Functional Magnetic Resonance Imaging;Funding;Future;Generations;Goals;Grant;Institution;Insula of Reil;interest;Knowledge;Learning;low socioeconomic status;Mentors;neural circuit;Neurobiology;Neurocognitive;neurofeedback;neuroimaging;neurophysiology;Neurosciences;older adult;Oral;parent grant;Physiological;Postdoctoral Fellow;Process;Publications;Research;research and development;Research Personnel;Risk;Science;Signal Transduction;skills;social;social neuroscience;Social Sciences;Statistical Data Interpretation;success;Testing;Time;Training;Trust;Work;Writing

PROJECT_TITLE: Characterizing and Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging (Diversity Supplement)


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Rare Diseases;Usher Syndrome

ORG_DEPT: NEUROSCIENCES

PHR: NARRATIVE Hearing loss is a major health problem that is frequently of genetic origin and commonly disrupts the development and function of hair bundles of cochlear hair cells. We propose here to study several genes linked to genetic forms of hearing loss that affect hair bundle development and function. We propose to elucidate the molecular function of these genes and the pathophysiological processes associated with mutations in these genes that cause hearing loss.

PI_NAMEs: MUELLER, ULRICH  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Affect;Antibodies;Binding;Biochemical;Biological;Birth;Cell Physiology;Cells;Clarin-1;Cochlea;Collaborations;Coupled;Data;deafness;Defect;Development;Disease;Electron Microscopy;Electrophysiology (science);Epitopes;gene function;Gene Modified;Genes;Genetic;Goals;Gold;Hair;Hair Cells;Health;hearing impairment;Human;Immunofluorescence Immunologic;Immunohistochemistry;insight;Knowledge;Laboratories;Letters;Lighting;Link;link protein;Maps;Methods;Microscopy;Molecular;Morphogenesis;Mus;mutant;Mutant Strains Mice;Mutation;Pathogenesis;Pathway interactions;Pattern;Process;protein complex;protein distribution;Proteins;Publishing;ribbon synapse;Role;Scanning Electron Microscopy;Sensory impairment;Structure;Synapses;Techniques;Tertiary Protein Structure;Testing;WHRN gene

PROJECT_TITLE: Molecular Mechanisms of Clarin-1 and Clarin-2 function in mechanosensory hair cells

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative This proposal is aimed at the fundamental development of exploiting acetal radicals in organic synthesis to provide rapid delivery of high-value ketones and vicinal heteroatom compounds. This research is poised to tackle challenges in forging challenging C–C bonds to provide chemists with new synthetic capabilities that improve access to pharmaceutically relevant compounds. Specifically, readily available, environmentally-friendly acetals are used to promote reactions that streamline the synthesis to fluorinated ketones and a diversity of chiral molecular scaffolds.

PI_NAMEs: KIM, DANIEL KWANWOO (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Development of Acetal Radicals in Organic Synthesis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: LONG BEACH

ORG_NAME: CALIFORNIA STATE UNIVERSITY LONG BEACH

ORG_STATE: CA

PHR: Human Immunodeficiency Virus Type 1 (HIV-1) and Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) remain significant public health concerns. Assembly of HIV-1 and SARS-CoV-2 virus particles occurs within cholesterol-rich membrane microdomains, or lipid rafts. This study will determine how the lipid- raft scaffold protein AnnexinA2 recruits both HIV-1 Nef and SARS-CoV-2 Spike to sites of viral assembly, which may inform the development of novel antiviral therapies.

PI_NAMEs: RAMIREZ, PETER WILLIAM (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Affect;Anti-viral Therapy;Binding;Biology;Calcium Binding;Cell membrane;Cell Physiology;Cell surface;Cells;Cellular Membrane;Cholesterol;Coronavirus;COVID-19 pandemic;CRISPR/Cas technology;Data;Development;Endoplasmic Reticulum;experimental study;Goals;Golgi Apparatus;HIV;HIV-1;Host Defense;Human;Infection;innovation;Integration Host Factors;Investigation;knock-down;Knock-out;Knowledge;Left;Lipid Binding;Maps;Mediating;Membrane;Membrane Microdomains;Modeling;Molecular;new therapeutic target;novel;novel therapeutic intervention;Outcome;pandemic potential;pathogen;Pathogenesis;pathogenic virus;Pathway interactions;Persons;pharmacologic;Population;Prevalence;Process;Proteins;Public Health;receptor;recruit;Research;Retroviridae;RNA Viruses;Role;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Scaffolding Protein;Site;Sphingolipids;Testing;Therapeutic;therapeutically effective;trafficking;Viral;Viral Matrix Proteins;Viral Proteins;Virion;Virus;Virus Assembly;Virus Diseases;Virus Replication;Virus-like particle

PROJECT_TITLE: Determining the role of AnnexinA2 in HIV-1 and SARS-CoV-2 assembly

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

PHR: PROJECT NARRATIVE: Despite the recent clinical successes of RNA therapeutic systems such as the COVID- 19 mRNA vaccines, there remain fundamental knowledge gaps in RNA therapeutic design and delivery that must be addressed to enable broad clinical translation. To bridge these gaps, the proposed program will develop ultrasensitive multiplexed tools to interrogate how RNA cargo and carrier properties govern functional RNA delivery and how RNA therapeutic systems and the host influence each other. Success of this work will build an integrated understanding of RNA therapeutic system design rules and host factors that govern RNA delivery and individual response.

PI_NAMEs: WU, CONNIE  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Adopted;Adsorption;Area;Biological;Clinical;clinical translation;COVID-19;design;Detection;Dimensions;Disease;Drug Delivery Systems;Engineering;Environment;experience;Foundations;Immune response;improved;in vivo;in vivo evaluation;individual response;innovation;Integration Host Factors;Knowledge;Messenger RNA;Methodology;Mission;Molecular;mRNA delivery;nanocarrier;nanomaterials;nanoparticle;nanoparticle drug;National Institute of General Medical Sciences;Pharmaceutical Preparations;programs;Property;Proteins;rational design;Renaissance;Resolution;RNA;RNA delivery;RNA vaccine;Scientific Advances and Accomplishments;screening;single molecule;success;System;Technology;therapeutic nanoparticles;therapeutic RNA;tool;Untranslated RNA;Work

PROJECT_TITLE: Multidimensional approaches to understand and improve RNA therapeutic design and delivery


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Cardiovascular;Diabetes;Maternal Health;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Recent studies have confirmed that endocrine interactions play a significant role in causing and contributing to various common health issues, especially obesity, type 2 diabetes, and the resulting cardiovascular problems. The objective of this proposal is to establish a strong connection between mammary gland and metabolic tissue in order to thoroughly investigate the way by which mammokines communicate in health and disease conditions. Our approach involves initially utilizing newly developed precision proteomics, transcriptomics, computational methods, validation, and assess the potential for new endocrine interactions to be used as therapies in mouse models of metabolic disorders.

PI_NAMEs: RAJBHANDARI, PRASHANT  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Adipocytes;Adipose tissue;Affect;Bioinformatics;Breast Feeding;Cardiovascular Diseases;Cardiovascular system;cell type;Cells;Child;Communication;Computing Methodologies;data integration;Development;Diabetes Mellitus;diabetes mellitus therapy;diabetes risk;Disease;Endocrine;Endocrine disruption;Endocrine Glands;Epithelium;experimental study;Goals;Health;health of the mother;Health Promotion;Hepatocyte;Homeostasis;Human;innovation;islet;Liver;Mammary Duct;Mammary gland;Maternal Health;maternal wellbeing;Metabolic;Metabolic Diseases;Metabolism;Mothers;mouse model;multiple datasets;Mus;neonatal health;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity biomarkers;obesity treatment;offspring;Organ;Pancreas;paracrine;Paracrine Communication;Pathologic;Pathway interactions;Phenotype;Physiological;Play;Principal Investigator;Proteomics;Research;Resources;Risk Reduction;Role;Signal Transduction;Signaling Molecule;success;Technology;Tissues;Training;transcriptomics;Validation;Woman

PROJECT_TITLE: Decoding endocrine and paracrine communication through mammokines

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-S (M3)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hypertension;Kidney Disease;Patient Safety;Prevention

ORG_CITY: CLEVELAND

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Public Narrative It is well known that patients with chronic kidney disease (CKD) are at a high risk of cardiovascular disease (CVD). However, the choice of antihypertension medications for blood pressure-lowering is still a topic of debate. The differences in the effects of these agents also remain unclear due to the limited number of clinical trials conducted. To address these questions, we will leverage data from two large-scale observational and clinical studies, namely the Chronic Renal Insufficiency Cohort (CRIC) and the Systolic Blood Pressure Intervention Trial (SPRINT). Our goal is to exclusively investigate the effects of these medications in CKD patients by employing advanced causal inference techniques. The methods we propose are general and can be applied to other studies and medical specialties facing similar analytical challenges. Software packages and a Shiny app will be publicly available for applications in research and clinical practice.

PI_NAMEs: RAHMAN, MAHBOOB ;WANG, MING  (contact)

PROGRAM_OFFICER_NAME: EINHORN, PAULA T

PROJECT_TERMS: Address;Adult;Affect;African American;African ancestry;analytical method;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Anti-Hypertensive Agents;Anti-Inflammatory Agents;Area;arm;Benefits and Risks;Biomedical Research;Biometry;Blood Pressure;blood pressure intervention;blood pressure medication;blood pressure reduction;Blood Vessels;Calcium Channel;Calcium Channel Blockers;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;cardiovascular risk factor;Cardiovascular system;Chronic Kidney Failure;Chronic Kidney Insufficiency;clinical decision-making;clinical practice;Clinical Practice Guideline;Clinical Research;cohort;Cohort Studies;Combination Medication;Combined Modality Therapy;Communities;comparative;Comprehension;Computer software;Conduct Clinical Trials;Consensus;cost;Data;Data Analytics;data resource;Data Science;Disease Outcome;Disease Progression;Diuretics;education resources;Effectiveness;Effectiveness of Interventions;Elements;Evaluation;Event;Exhibits;experience;flexibility;Goals;Grant;Health;high risk;Hypertension;illness length;improved;inhibitor;innovation;Intervention Trial;Kidney;Kidney Diseases;Knowledge;large scale data;Mediating;Mediation;Mediator;medical specialties;Methods;Mission;mortality;mortality risk;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;novel;Observational Study;Outcome;Participant;Patients;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Population;Probability;Property;Public Health;Race;randomized, clinical trials;real time monitoring;Recommendation;renal damage;Renal function;Renin-Angiotensin System;Research;Risk;Risk Reduction;Sampling;Scheme;Selection Bias;Severity of illness;simulation;Statistical Methods;Structural Models;Structure;Subgroup;Techniques;Time;tool;treatment comparison;treatment effect;treatment group;treatment strategy;United States;user friendly software;user-friendly;Variant;web site;Weight;Work

PROJECT_TITLE: Assessment of the Impact of antihypertensive Medications on vascular and renal outcomes in Chronic Kidney Disease (AIM-CKD)

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Digestive Diseases;Immunization;Orphan Drug;Precision Medicine;Rare Diseases;Stomach Cancer;Women's Health Research

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE – The vast majority of patients with advanced gastric cancers become refractory to anti- HER2 antibody-drug therapies. The use of predictive biomarkers to guide antibody-drug response are necessary for improving survival in patients with gastric cancer and for sparing them from unnecessary toxicity. This proposal seeks to optimize a novel non-invasive imaging approach that can identify the sensitivity or resistance of Trastuzumab-drug conjugates in gastric cancer.

PI_NAMEs: RIBEIRO PEREIRA, PATRICIA MANUELA  (contact);TU, ZHUDE

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Aftercare;Antibodies;Antibody Therapy;Antibody-drug conjugates;Binding;Biological;Biological Markers;Classification;Clinic;Clinical;Clinical Research;clinical translation;Data;Drug resistance;Early treatment;Environment;ERBB2 gene;Evaluation;Exhibits;experience;FDA approved;feasibility testing;Foundations;Funding;Future;gastric cancer cell;Goals;Human;Image;image guided;imaging approach;imaging biomarker;imaging study;Imaging Techniques;ImmunoPET;improved;In complete remission;ineffective therapies;inhibitor;innovation;Investigation;Label;Lead;Malignant Breast Neoplasm;Malignant Neoplasms;malignant stomach neoplasm;Measurement;Measures;Membrane;Methods;molecular imaging;Monitor;mouse model;Mus;Mutation;new therapeutic target;non-invasive imaging;novel;Outcome;outcome prediction;Pathway interactions;patient derived xenograft model;Patient Selection;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phosphotransferases;Positron-Emission Tomography;potential biomarker;pre-clinical;preclinical study;predictive marker;Proteins;Radiolabeled;radiotracer;Randomized;receptor;Refractory;Reproducibility;Research;Research Personnel;Resistance;Resistance development;resistance mechanism;response;Role;Saline;Sampling;Signal Transduction;small molecule;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Stomach;Stomach Neoplasms;targeted imaging;targeted treatment;Testing;Therapeutic Studies;therapy outcome;Time;Tissues;Toxic effect;Translational Research;Trastuzumab;Treatment Efficacy;Treatment outcome;treatment response;tumor;Tumor Antibodies;tumor heterogeneity;Tumor Markers;Tumor Volume;uptake;Validation

PROJECT_TITLE: S1PR1-targeted PET imaging to predict and monitor response to HER2-targeting antibody-drug conjugates

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (M2)]


NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE RNA binding proteins (RBPs) help manage cell functions by interacting with RNA in specific locations within cells, and these interactions can change, especially under stress or in disease. Current techniques struggle to pinpoint these interactions precisely inside cells. Our proposal outlines innovative methods to map these interactions, which could improve the understanding and treatment of diseases linked to RBP malfunctions.

PI_NAMEs: LUNA, JOSEPH M (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Cell model;Cell Physiology;Cells;Computer Analysis;Data;Data Set;design;Disease;Event;experimental analysis;Foundations;Future;Health;Human;improved;Individual;innovation;insight;Knowledge;Label;Light;Link;Location;Maps;Membrane;Methods;Modeling;novel;Organelles;Pathologic;Physiological;Play;posttranscriptional;predictive modeling;Process;programs;Protein Biosynthesis;Resolution;ribosome profiling;RNA;RNA Binding;RNA metabolism;RNA-Binding Proteins;RNA-Protein Interaction;Role;Spatial Distribution;Stress;stress granule;Subcellular Spaces;System;Techniques;Testing;Therapeutic;tool;transcriptome sequencing;Translations

PROJECT_TITLE: Mapping RNA Binding Protein Interactions Within Cellular Microenvironments

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-D (55)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Electronic Nicotine Delivery Systems;Immunotherapy;Infectious Diseases;Lung;Lung Cancer;Prevention;Rare Diseases;Tobacco;Tobacco Smoke and Health

ORG_CITY: DURHAM

ORG_NAME: NORTH CAROLINA CENTRAL UNIVERSITY

PHR: PROJECT NARRATIVE Although the deleterious effects of traditional cigarette smoking have been documented widely, significantly less is known about the health effects and safety profiles of new (introduced widely only within the past 15 yrs) and emerging tobacco products, i.e., E-cigarettes, on the lung. This proposal seeks to expand upon our understanding of the use and effect(s) of new and emerging tobacco products. Through these studies, we will (1) mechanistically investigate the pulmonary consequences of E-cigarette use, or vaping, and (2) whether vaping renders the lung more susceptible to pulmonary disease initiation and progression due to microbial challenge.

PI_NAMEs: ONYENWOKE, ROB U (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: A549;Acute;Acute Lung Injury;adaptive immunity;Aerosols;airway epithelium;airway inflammation;Alveolar Macrophages;Bacteria;Biological Assay;Bioluminescence;bronchial epithelium;Cell Count;Cell Line;Cell model;Cell Proliferation;Cell Survival;Cells;Chronic;cigarette smoke;cigarette smoking;combustible cigarette;combustible tobacco;Consumption;cytokine;Cytokine Activation;cytotoxicity;Data;Development;disability;Disease;Distal;Distress;Dose;Electronic cigarette;electronic cigarette use;electronic cigarette user;electronic liquid;Emerging Tobacco Products;Endotoxins;Epithelial Cells;Euthanasia;Exposure to;Flow Cytometry;functional status;Goals;Health;Human;Immune;Immune Cell Suppression;Immune response;Immune System Diseases;immunosuppressed;Immunosuppression;In Vitro;in vivo;in vivo imaging system;in vivo Model;Infection;infection rate;Infectious Agent;Inflammation;Inflammatory Response;Klebsiella pneumoniae;Knowledge;Lipopolysaccharides;Lung;Lung Diseases;Lung infections;lung injury;Malignant neoplasm of lung;Marketing;Measures;Mediating;microbial;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myeloid-derived suppressor cells;Natural Immunity;Necrosis;neutrophil;Nosocomial Infections;novel;Organ;Outcome;pathogen;pathogenic microbe;Pathology;Phenotype;Pneumonia;Population;Predisposition;Primary Cell Cultures;Property;pulmonary function;Pulmonary Inflammation;Pulmonary Pathology;recruit;Resolution;Respiratory Disease;Respiratory Tract Infections;Risk;Safety;Smoke;Spirometry;Stains;Syndrome;Time;Tobacco smoking behavior;Toxic effect;vaping

PROJECT_TITLE: Vaping has an immunosuppressive effect, rendering the lung more susceptible to microbial infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (SF)]


NIH_SPENDING_CATS: Genetics;Human Genome;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: NORFOLK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: EASTERN VIRGINIA MEDICAL SCHOOL

ORG_STATE: VA

PHR: Project Narrative: Idiopathic Pulmonary Fibrosis (IPF) is a fatal disease with altered epigenomics and associated with high mortality. This proposal will explore if blocking Brd4, an epigenetic regulator, will block the upregulation of profibrotic genes thus alter the cell phenotype. This study will evaluate the efficacy of using Brd4 inhibitor as a therapeutic method to improve the resolution of persistent lung fibrosis; the completion of this study will further our understanding of this deadly disease and uncover novel therapeutic molecular targets.

PI_NAMEs: SANDERS, YAN  (contact);THANNICKAL, VICTOR J.

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acetylation;Acetyltransferase;Actins;Adult;Affect;Apoptosis;ATAC-seq;Automobile Driving;Binding;Binding Sites;Biological Assay;Bromodomain;C57BL/6 Mouse;Cardiac;Cell Physiology;cell type;Cells;Cellular Stress;Chromatin;chromatin immunoprecipitation;chromatin modification;Collagen;CRISPR/Cas technology;Data;Disease;Down-Regulation;efficacy evaluation;Elements;Enhancers;Enzymes;EP300 gene;Epigenetic Process;epigenetic regulation;epigenomics;Etiology;Family;Fibroblasts;Fibrosis;Gene Expression;Genes;Genetic Transcription;genome-wide;Hematology;Histone Acetylation;histone acetyltransferase;histone modification;Histones;idiopathic pulmonary fibrosis;improved;in vivo;in vivo Model;inhibitor;Kidney;Knockout Mice;Liver Fibrosis;Lung;Lung Diseases;lung injury;lung repair;Lysine;Maps;Mediating;member;Methods;molecular targeted therapies;mortality;Myofibroblast;NADPH Oxidase;novel;novel therapeutics;old mice;Organ;Pancreas;Pathogenesis;pharmacologic;Phase I/II Clinical Trial;Phenotype;Play;Post-Translational Protein Processing;Pre-Clinical Model;Process;profibrotic cytokine;promoter;Promoter Regions;Proteins;Pulmonary Fibrosis;Reader;recruit;Regulatory Element;repaired;Reporting;Research;Resolution;response;Role;Small Interfering RNA;Smooth Muscle;Solid Neoplasm;Testing;Therapeutic;therapeutic target;transcription factor;Transcriptional Regulation;transcriptional reprogramming;Transforming Growth Factors;Up-Regulation

PROJECT_TITLE: Bromodomain-containing Protein 4 in Profibrotic Gene Expression and Lung Fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular

PHR: PROJECT NARRATIVE  This investigation addresses the clinical need to assess the long-term impact of thoracic endovascular aortic repair using multiple endografts for the dissected aorta, by identifying the key biomechanical and hemodynamic features to characterize aortic remodeling. The proposed technology will provide essential data to select the patients who can expect a favorable outcome, help find the optimal composition of devices to treat the patient, provide a reliable guideline for CT-based feature extraction to track the long-term aortic remodeling during the follow-up period and determine the optimal interval to acquire the follow-up CTs. The results data will be applicable to improve the current endograft design to the next level to treat extensively dissected aorta.

PI_NAMEs: SUH, GA-YOUNG KELLY (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;Address;Aorta;aortic arch;Aortic Diseases;Aortic Rupture;Biomechanics;Blood;Blood flow;Chest;Clinical;Comparative Study;Computer Analysis;computer framework;Computer Models;Data;design;Devices;Diameter;Disease;Dissection;Distal;FDA approved;feature extraction;follow up assessment;follow-up;Geometry;Goals;Guidelines;hemodynamics;Hemorrhage;Human;Implant;improved;indexing;Intestines;Investigation;Kidney;Left;Length;Life;Liquid substance;Longterm Follow-up;Measures;Metals;Monitor;next generation;Operative Surgical Procedures;Outcome;Patient Selection;Patients;Persons;pressure;prevent;radiological imaging;repaired;Rupture;seal;Selection Criteria;shear stress;Spinal Cord;Stents;Techniques;Technology;Textiles;Thoracic aorta;Time;Tubular formation;Vascular blood supply;X-Ray Computed Tomography

PROJECT_TITLE: Biomechanics and Hemodynamics of Human Aorta with Remodeling after Endovascular Repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-7 (SF)]