ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE Understanding how cell fates are specified in the embryo is a long standing goal of developmental biology. Here we explore a previously unappreciated epithelial to mesenchymal transition in the posterior endoderm, one of the three germ layers that comprise the early embryo, wherein cells invade the neighboring tailbud mesenchyme and potentially contribute to neuromesodermal fates. Understanding signals that regulate this process, the identity of these cells and their progeny, and their potential to differentiate along a remarkably wide range of lineages may have potentially far reaching implications for the study of induced pluripotency, cell reprogramming, and directed differentiation, as well as the pathogenesis of cancer, which commonly originates in endodermally derived tissues, and propagates via epithelial to mesenchymal transition.

PI_NAMEs: NERURKAR, NANDAN L (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Adult;Atlases;Biochemical;Biophysics;Birds;Brain;cell behavior;cell fate specification;Cell Line;Cell Reprogramming;Cells;Chick Embryo;Complex;Cues;Development;Developmental Biology;directed differentiation;Dorsal;Ectoderm;Ectoderm Cell;Embryo;Embryology;Embryonic Development;Endoderm;Endoderm Cell;epithelial to mesenchymal transition;experimental study;gastrulation;Genes;Germ Layers;Goals;in vivo Model;Invaded;Investigation;Malignant Neoplasms;Maps;Mesenchyme;Mesoderm;Mesoderm Cell;Multipotent Stem Cells;Neural tube;notochord;novel;Organ;Pathogenesis;Pattern;pluripotency;Population;Process;progenitor;programs;prospective;Regulation;Research;segregation;Shapes;Signal Transduction;single-cell RNA sequencing;Source;Specific qualifier value;stem;stem cell population;stem cells;Stereotyping;Surface;Time;Tissues;Totipotent;transcriptomics;Tube;Work

PROJECT_TITLE: Investigation of a neuromesendodermal progenitor population in the posterior avian endoderm

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Family caregivers play a central role during a Veteran’s critical care (medical care for a life-threatening illness or injury) hospitalization and survivorship. Yet, up to 73% of caregivers experience anxiety and 97% experience depression during a critically ill patient’s hospital stay. Addressing family caregiver needs, including informational and emotional processing, social support and self-care, during key moments early in a family’s crisis may moderate the development of caregiver psychological distress. This research focuses on determining common key moments in the caregiver experience that can lead to distress (Aim 1), designing psychosocial intervention components to meet caregiver needs during these key moments (Aim 2), and testing the feasibility and acceptability of these components (Aim 3), which seek to moderate the development of psychological distress among caregivers of critically ill Veterans.

PI_NAMEs: BLOK, AMANDA CONSTANCE (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Admission activity;Anxiety;anxiety reduction;arm;Award;Awareness;Behavior;career;Caregiver support;Caregiver well-being;Caregivers;Caring;Clinical;Clinical Trials;Complex;Conduct Clinical Trials;connected care;Critical Care;Critical Illness;Data;decision-making capacity;design;Development;Distress;effectiveness/implementation trial;Elements;Emotional;Environment;Evidence based practice;experience;Family;Family Caregiver;family support;feasibility testing;Feedback;Funding;Goals;Health;Hospitalization;Impairment;informal caregiver;information processing;Injury;innovation;Intervention;intervention delivery;Interview;Knowledge acquisition;Length of Stay;Life;Link;loved ones;Medical;meetings;member;Mental Depression;Mentorship;Methodology;Methods;mobile computing;Nurses;Outcome;Outcome Measure;Patient Admission;patient engagement;Patients;Pattern;Persons;Pilot Projects;Play;Process;programs;psychological distress;Psychological Impact;psychosocial;Psychosocial Assessment and Care;psychosocial resources;Qualitative Methods;Readiness;Recovery;Research;Research Methodology;Research Personnel;Research Proposals;Resources;Role;Scientist;Self Care;Social support;Structure;Surveys;Survivors;survivorship;Technology;technology intervention;Testing;theories;therapy design;therapy development;Time;tool;Training;usability;user centered design;Veterans;virtual healthcare;Visual;Vulnerable Populations;Work

PROJECT_TITLE: Family-Centered Co-Design of a Technology-Facilitated Intervention for Family Caregivers of Critical Care Survivors

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: GALVESTON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Project Narrative Arthropod-borne viruses, such as dengue, Zika and Mayaro, are emerging at an accelerating rate in Central and South America. The Coordinating Research on Emerging Arboviral Threats Encompassing the Neotropics (CREATE-NEO) project will provide a nimble and flexible network of surveillance sites in Central and South America coupled to cutting-edge modeling approaches in order to anticipate and counter these threats to public health.

PI_NAMEs: HANLEY, KATHRYN ALYCE;VASILAKIS, NIKOS  (contact)

PROGRAM_OFFICER_NAME: WOODSON, SARA ELAINE

PROJECT_TERMS: Acceleration;Acute;Address;Age;Americas;Animals;arboviral disease;Arbovirus Infections;Arboviruses;Area;arthropod-borne;Back;Biodiversity;Brazil;Central America;Chikungunya virus;Circulation;Cities;climate change;Clinical;cohort;Cohort Studies;Collection;Coupled;Culicidae;Data;Deforestation;Dengue Virus;design;Detection;diagnostic technologies;Disease;Emergency Situation;emerging pathogen;enzootic;Enzyme-Linked Immunosorbent Assay;experience;flexibility;Frequencies;Genetic Recombination;Genetic Variation;Habitats;high risk;Human;Immune;Infection;insight;International;Invaded;Invertebrates;Machine Learning;Malaria;Maps;Mayaro virus;Measles;Mediating;Modeling;Movement;nanobodies;nonhuman primate;novel;novel diagnostics;Oropouche virus;Panama;pathogen;prospective;Public Health;Research;Risk;Route;Sampling;seroconversion;Site;South America;Spatial Distribution;Structure;surveillance network;Testing;Time;transmission process;Travel;Vaccination;vector;vector control;Vector-transmitted infectious disease;Venezuela;viral transmission;Virus;West Nile virus;Yellow Fever;Yellow fever virus;Zika Virus;Zoonoses

PROJECT_TITLE: Coordinating Research on Emerging Arboviral Threats Encoing the Neotropics (CREATE-NEO)


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PISCATAWAY

ORG_DEPT: GENETICS

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative: The cells lining our intestine are critical for absorbing nutrients, preventing infection, and are the source of colon cancer. These cells are not uniform, but perform specialized functions, and in turn, these different cells utilize energy differently. The proposed work is relevant to human health because it will reveal how cellular metabolism is controlled in different cell types lining the intestine; and new mechanisms of metabolic control could provide therapeutic entry points to bolster regenerating cells to repair the intestine or suppress changes induced by an obesogenic diet.

PI_NAMEs: VERZI, MICHAEL P. (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: 3-Dimensional;Adult;Automobile Driving;Binding;Binding Proteins;Binding Sites;Biogenesis;Biological Assay;Cell Line;cell regeneration;Cell Respiration;cell type;Cells;Cellular Metabolic Process;Chromatin Loop;cofactor;Colon Carcinoma;Data;Development;Diet;dietary;dietary excess;Dietary Fats;Disease;Electron Transport;Energy-Generating Resources;Enhancers;Enterocytes;Environment;enzyme activity;epigenomics;Epithelial Cells;Epithelium;epithelium regeneration;ERR1 protein;estrogen-related receptor;Exposure to;fatty acid oxidation;Fatty Acids;fetal;Gene Expression;Gene Expression Regulation;Genes;Genetic Models;Genetic Transcription;Genome;Glycolysis;Goals;Health;High Fat Diet;HNF4A gene;Homeostasis;Human;Infection prevention;insight;Intestinal Diseases;intestinal epithelium;Intestines;Knock-out;Knockout Mice;life span;Link;Literature;Malignant Neoplasms;Mediating;Metabolic;Metabolic Control;Metabolism;metabolomics;Mitochondria;mouse model;Muscle;mutant mouse model;Natural regeneration;new technology;novel;Nuclear Receptors;nutrient absorption;obesity risk;obesogenic;Organogenesis;Organoids;oxidation;Oxidative Phosphorylation;Oxygen;paralogous gene;Pathologic;Play;Process;promoter;Proteomics;regenerative;Regulation;repaired;Reporting;Research;Respiration;response;response to injury;Role;Shapes;Source;stem;stem cell division;stem cells;stemness;Stress;Testing;Therapeutic;tissue regeneration;Tissues;transcription factor;tumorigenesis;Up-Regulation;Villus;Work;YY1 Transcription Factor

PROJECT_TITLE: Mechanisms Driving Metabolic Shifts in the Intestinal Epithelium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_DEPT: PEDIATRICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: The National Institutes of Environmental Health Sciences (NIEHS) has prioritized the need to examine health effects of chemical mixtures, as well as the joint effects of chemical and social stressors, to better reflect real-life exposure scenarios and inform more refined policies to protect the public. We will address gaps in our understanding of the role of metal exposures in the prenatal programming of transdiagnostic pathways to preadolescent anxiety and depressive symptomatology, including interactions with broadly measured stress domains, and the role of placenta signaling. Explicating modifiable environmental risk factors and early biomarkers of risk so that interventions can be applied early to promote optimal development may have significant implications for prevention of chronic psychopathology.

PI_NAMEs: WRIGHT, ROSALIND J (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Adolescence;Affect;Age;Anxiety;Anxiety Disorders;Arousal;Arsenic;Attention;Attention deficit hyperactivity disorder;Autonomic nervous system;Behavior;behavior measurement;Behavioral;Biogenesis;biological adaptation to stress;Biological Assay;Biological Markers;Biological Testing;Birth;Blood;Brain;Brain region;Cadmium;Central Nervous System;Chemicals;Childhood;Chronic;Clinical;Cognition;cognitive control;cognitive process;cognitive system;cohort;comorbidity;Complex;Complex Mixtures;Conduct Disorder;Data;Depressive disorder;depressive symptoms;Development;Diagnostic;Dimensions;Disease;early detection biomarkers;early life adversity;Emotional disorder;Environment;environmental chemical;Environmental Risk Factor;Event;Exposure to;externalizing behavior;fetal;follow-up;General Population;Health;hypothalamic-pituitary-adrenal axis;in utero;Individual;infancy;Intelligence;Intervention;Joints;Lead;Learning;lens;Life;Link;Longitudinal Studies;Manganese;Measures;Mediation;Mediator;Mental Depression;Mental Health;Mercury;Metal exposure;metal poisoning;Metals;MicroRNAs;Molecular;Mood Disorders;Morbidity - disease rate;Motion;National Institute of Environmental Health Sciences;Negative Valence;nervous system development;neural;Neurosecretory Systems;neurotoxicity;Outcome;Oxidative Stress;Pathway interactions;Performance;Persons;Physiological;Placenta;Plasma;Policies;post-traumatic symptoms;preadolescence;Pregnancy;prenatal;prenatal exposure;prenatal stress;Prevention;Process;programs;psychologic;Psychopathology;Psychosocial Factor;Psychosocial Stress;Public Health;Regulation;Research;Research Domain Criteria;Risk;Risk Assessment;Risk Factors;Role;Shapes;Signal Transduction;social stressor;Stress;stressor;symptomatology;Symptoms;Synaptic Transmission;System;theories;Time;Tissues;trait;Umbilical Cord Blood;Work;Youth;Zinc

PROJECT_TITLE: Prenatal metal-stress mixtures and transdiagnostic pathways to preadolescent internalizing disorders: Role of placental molecular signaling

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Lung;Precision Medicine;Pulmonary Hypertension

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The field of Redox Biology is rapidly advancing with the introduction of improved tools and insight to understand how disrupted redox-regulated signaling pathways contribute to pathogenesis of pulmonary vascular diseases. This project will establish how the content or distribution of a critical vascular antioxidant enzyme, extracellular superoxide dismutase, contributes to pathologic redox regulated signaling in pulmonary hypertension and provide the foundation for novel targeted therapeutic approaches.

PI_NAMEs: NOZIK, EVA S. (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Age;Animal Model;antioxidant enzyme;Award;Binding;Biology;Blood Vessels;CD44 gene;Cell Communication;Cells;design;Development;Disease;Electron Spin Resonance Spectroscopy;enzyme activity;epigenetic regulation;experimental study;extracellular;Extracellular Matrix;Fibroblasts;Fibrosis;Foundations;Funding;Future;Gene Expression;Genetic Polymorphism;Growth;Half-Life;Homeostasis;Human;Hyaluronan;improved;In Vitro;in vivo;Individual;individual variation;Inflammasome;Inflammation;insight;Knock-in;Knowledge;Location;Lung;Macrophage;Metabolism;Mission;mitochondrial dysfunction;Modification;Mouse Strains;Mus;Natural Immunity;new therapeutic target;novel therapeutic intervention;Oxidation-Reduction;Pathogenesis;Pathologic;Precision Medicine Initiative;Predisposition;programs;Property;Pulmonary Circulation;Pulmonary Hypertension;pulmonary vascular disorder;receptor;Regulation;Research;Research Infrastructure;Research Project Grants;Resource Sharing;response;Series;Severities;Signal Pathway;Signal Transduction;Superoxide Dismutase;Testing;tool;Transforming Growth Factor beta;Translating;Translations;Vascular remodeling;Work

PROJECT_TITLE: SOD3 regulation of redox sensitive signaling in pulmonary vascular diseases


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Psychosis;Schizophrenia;Serious Mental Illness;Women's Health Research

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative  The use of antipsychotic medication among pregnant and lactating women has increased in frequency in recent years. However, antipsychotic efficacy for psychiatric illness has not been directly tested in this population, and many unanswered questions remain about the potential effects of antipsychotics on the development of the fetus, neonate, and infant. We hope to determine whether antipsychotics are effective for pregnant women with severe mental illness and whether they have any measurable effects on infant development.

PI_NAMEs: ROBAKIS, THALIA K (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Adolescence;Adverse effects;adverse pregnancy outcome;Affect;antenatal;Antipsychotic Agents;anxiety symptoms;Auditory;Behavior;behavior observation;behavioral outcome;Bipolar Disorder;Body Size;Caring;Child;Clinical;Cognitive;comparison group;Controlled Study;course development;Data;Data Set;Development;Diagnosis;Disease;Dopamine;Dopamine D2 Receptor;Electroencephalography;emerging adult;Emotional;Equilibrium;Exposure to;Female of child bearing age;Fetal Development;Fetus;Frequencies;Fright;Gestational Diabetes;Goals;Growth;Hemorrhage;Home visitation;in utero;Infant;Infant Development;infant outcome;Interneurons;Interview;Investigation;Lactation;Longitudinal cohort study;male;Measurable;Measures;Mediating;Mental Depression;Mental disorders;Mood stabilizers;Moods;Mothers;Motor;Neonatal;neonatal outcome;neonate;nerve stem cell;Netherlands;neural;neurobehavioral;non-affective psychoses;Observational Study;obstetric outcomes;offspring;Outcome;Outcome Study;Perinatal;Pharmaceutical Preparations;Pilot Projects;Placenta;Population;Postpartum Period;Pre-Eclampsia;Prefrontal Cortex;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;prenatal exposure;Prevalence;Proliferating;prospective;Psychiatry;Psychoses;psychosocial outcome;psychotic;Psychotic Disorders;Pyramidal Cells;recruit;Relapse;Risk;risk/benefit ratio;sensory gating;Serum;severe mental illness;sex;Short-Term Memory;Signal Transduction;Social Functioning;spatial memory;Syndrome;Testing;Time;Toddler;Woman;women's treatment

PROJECT_TITLE: Developmental effects of antenatal exposure to antipsychotics


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: WASHINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Understanding the effects of vertical integration on healthcare quality, patient outcomes, and cost will be of high importance to payers and policymakers, in deciding how to respond to the vertical integration trend. If we find quality improvements, this would justify investing in and encouraging vertical integration. If we find no significant effects or negative effects on quality, this would support policies that discourage integration.

PI_NAMEs: MOGHTADERI, ALI  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Acute myocardial infarction;Address;Affect;Ambulatory Care;Area;Cardiac;Cardiology;Cardiovascular Diseases;Cardiovascular system;care coordination;care costs;care delivery;Caring;Classification;clinical practice;Collaborations;Colorado;Complex;cost;Data Set;Employment;Evaluation;experience;financial incentive;Growth;Health;health care delivery;health care quality;Health Services;Healthcare;Heart failure;Hospitalization;Hospitals;improved;innovation;Inpatients;Insurance Carriers;Investments;Left Ventricular Ejection Fraction;Length of Stay;Location;Longitudinal cohort;Measures;medical specialties;Medicare;Methods;Monitor;mortality;multidisciplinary;Natural experiment;novel;Outcome;Outpatients;parity;Patient Care;Patient-Focused Outcomes;Patients;payment;Physicians;Pilot Projects;pilot test;Policies;Policy Maker;Price;Private Practice;Procedures;Process;Provider;readmission rates;Recurrence;Research;Research Design;Research Personnel;research study;revascularization;Sample Size;Sampling;Sampling Studies;Sea;Services;Taxes;Testing;Time;time use;Treatment Failure;trend;Variant;Visit

PROJECT_TITLE: Effect of Hospital-Cardiologist Integration on Clinical Practice, Healthcare Quality, and Medicare Spending

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: RELEVANCE  Investigating the mechanism of action of the cytokine macrophage migration inhibitory factor is essential to better understand its genetic contribution to rheumatoid arthritis, which is the most common inflammatory arthritis in the United States. Experiments with mouse models and cell cultures are excellent tools for such studies, which also permit evaluation of precision-based treatments that may be tailored to patients with high expression forms of the MIF gene.

PI_NAMEs: BUCALA, RICHARD J (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Acceleration;Adoptive Transfer;Alleles;Arthritis;arthropathies;Autoimmune Diseases;Binding;Biological Response Modifier Therapy;Blood;Cardiovascular Diseases;CD44 gene;Cell Culture Techniques;Cells;Chronic Childhood Arthritis;Clinical;Collagen;cytokine;Data;Disease;Disease Progression;drug-like compound;effective therapy;Evaluation;Exons;experience;Experimental Arthritis;experimental study;Fc Receptor;Fibroblasts;Genes;Genetic;Genetic Polymorphism;Genotype;Glucocorticoids;Human;human migration;Immunology;immunopathology;Induction of Apoptosis;Inflammation;Inflammatory;Inflammatory Arthritis;inhibitor;insight;joint destruction;Joints;Laboratories;life span;Macrophage;Mediating;Memory;Microsatellite Repeats;Migration Inhibitory Factor;Morbidity - disease rate;mouse model;Mouse Strains;Mus;novel;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;peripheral blood;Phase;Phenotype;Play;Population;Production;programs;promoter;Protein Isoforms;prototype;receptor;Recurrent disease;Refractory;Relapse;research clinical testing;response;Rheumatoid Arthritis;risk variant;RNA Splicing;Role;Scleroderma;Signal Transduction;Site;Symptoms;Synovial Fluid;Synovial joint;Synovial Membrane;Synovitis;Systemic Lupus Erythematosus;T cell response;T memory cell;T-Lymphocyte;Testing;Tissues;tool;trafficking;transcription factor;translational impact;treatment response;United States;Variant;Vasculitis;Work

PROJECT_TITLE: Defining the Pathogenic Contribution of High Genotypic MIF Expression


NIH_SPENDING_CATS: Duchenne/ Becker Muscular Dystrophy;Genetics;Human Genome;Muscular Dystrophy;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Duchenne muscular dystrophy (DMD) is a devastating pediatric disease caused by mutations in the dystrophin gene, leading DMD boys to wheelchair, followed by premature death within the second/third decade of their life. There is not yet a definitive cure of the disease; however, the recent entry into clinical trials of gene therapies approaches aimed at restoring dystrophin in DMD boys prompted an interest to evaluate the full spectrum of alterations caused by dys deficiency and whether they can be completely or partly restored upon gene therapy. This proposal will address this urgent issue, by investigating the relationship between dystrophin deficiency and the altered tri-dimensional genome topology and deregulated gene expression in DMD muscles, and by determining whether these alterations could be reversed upon dystrophin replacement.

PI_NAMEs: PURI, PIER LORENZO (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Architecture;ATAC-seq;Binding;Bioinformatics;boys;Cells;Cessation of life;Childhood;ChIP-seq;Chromatin;Chromatin Structure;chromosome conformation capture;Chronic Disease;Data;Data Analyses;Dimensions;Disease;Disease Progression;Duchenne muscular dystrophy;Dystrophin;Elements;Epigenetic Process;Evaluation;Event;Exhibits;Experimental Models;Fingerprint;follow-up;functional genomics;Funding;Gene Expression;Gene Expression Profile;Gene Expression Profiling;gene therapy;gene therapy clinical trial;Genes;Genetic Transcription;Genome;genome integrity;genome-wide;Genomic Instability;Genomics;Hi-C;histone modification;Human;human induced pluripotent stem cells;human model;in vivo;in vivo Model;induced pluripotent stem cell;interest;Knowledge;Life;Logic;mdx mouse;membrane skeleton;Modeling;mouse model;Mus;Muscle;Muscle Contraction;Muscle Fibers;Muscular Dystrophies;mutant;Mutation;Nuclear;Output;Pathogenesis;Pathogenicity;Patients;Predisposition;premature;promoter;protein complex;Recovery;Regulation;response;restoration;Sarcolemma;skeletal;Skeletal Muscle;skeletal muscle wasting;Stimulus;Technology;Therapeutic;Transcription Alteration;transcriptome;transcriptome sequencing;Transforming Growth Factor beta;Treatment Efficacy;treatment response;United States National Institutes of Health;Untranslated RNA;virulence gene;Wheelchairs;Wild Type Mouse

PROJECT_TITLE: Pathogenic Alterations of the 3D Epigenetic Landscape in Dystrophin-Deficient Skeletal Muscles and Reversal by Dystrophin Re-Expression


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BOSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative The goal of our research program is to understand the mechanisms that eliminate proteins from the cell. Because protein breakdown regulates important processes such as cell division, understanding these pathways may help us develop new treatments for diseases such as cancer.

PI_NAMEs: KING, RANDALL W (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Biological;Biology;Cell division;Cell Physiology;Cell Survival;Cells;Disease;drug development;enzyme substrate;Enzymes;Excision;experimental study;Genome;Goals;Health;Human;insight;interest;Knowledge;Malignant Neoplasms;Methods;Modernization;Modification;Molecular Target;multicatalytic endopeptidase complex;Mutation;new therapeutic target;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;Process;programs;protein protein interaction;Proteins;Proteomics;Regulation;Regulatory Pathway;Research;Role;Signal Transduction;Specificity;Substrate Specificity;System;Ubiquitin;ubiquitin ligase;Ubiquitin-Conjugating Enzymes;Ubiquitination;virtual

PROJECT_TITLE: Mechanistic Analysis of the Ubiquitin-Proteasome System

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Childhood voice disorders can have profound influences on communication that, in turn, can impact physical, cognitive, and emotional development. Here we leverage the expertise of a multidisciplinary team to develop objective measures of voice quality, specifically targeting the pediatric population in the first NIH-funded laboratory study of pediatric voice quality perception. This pre-translational research introduces a theoretical framework grounded in principles and models from auditory perception and is focused on improving diagnostic procedures and treatment outcome measures for children.

PI_NAMEs: DEALARCON, ALESSANDRO ;EDDINS, DAVID A. (contact);SHRIVASTAV, RAHUL

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Adult;Aftercare;Age;age difference;Anatomy;Area;Auditory Perception;Award;Basic Science;Behavioral;bench to bedside;Child;Childhood;Clinical;Clinical assessments;clinical decision-making;clinical practice;Clinical Protocols;Clinical Research;Clinical Trials;clinically relevant;Cognitive;cognitive neuroscience;Communication;Computing Methodologies;Data;Databases;design;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Dimensions;Disease;Dryness;Dysphonia;Emotional;Ensure;Evaluation;evidence base;experience;Funding;Future;guided inquiry;Health;Healthcare;Hearing;Height;High Prevalence;Human;improved;improved outcome;indexing;innovation;Knowledge;knowledge base;Laboratories;Laboratory Study;Language;Leadership;Measurement;Measures;Medical center;meetings;Methods;Modeling;multidisciplinary;National Institute on Deafness and Other Communication Disorders;NIH Program Announcements;novel;Outcome;Outcome Measure;Pathologist;Patients;Pediatric Hospitals;Perception;perceptual organization;Periodicity;personalized diagnostics;Phonation;Physiology;Pitch Perception;Population;Prevalence;Procedures;Process;programs;Property;Protocols documentation;Qualifying;Rapid diagnostics;Reporter;Research;Research Methodology;Research Personnel;Resources;Role;Running;Science;Series;Severities;signal processing;Signal Transduction;Site;Source;Speech;statistics;Stimulus;Strategic Planning;success;Targeted Research;Testing;Time;Translational Research;Treatment outcome;United States National Institutes of Health;Voice;Voice Disorders;Voice Quality

PROJECT_TITLE: Pediatric dysphonia: Multidisciplinary advances to improve voice quality outcomes

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: The NJ/NY Hazardous Materials Worker Training Center will provide training in hazardous materials, environmental careers, and disaster preparedness in Federal Region 2. The public health impact of training provided by the Center will prevent and reduce injuries and illness due to potential risks during hazardous waste operations, emergency and disaster response. Training provided is the vital to educating workers in safety and health issues. The Center is well-prepared to conduct the training proposed in this application. Center members have significant existing collaborations with their proposed target populations. The Center has successfully met their training projections in previous years of funding. The Center has trained over 450,000 workers, providing over 3.8 million contact hours of training with funds from the NIEHS WTP.

PI_NAMEs: ROSEN, MITCHEL A (contact)

PROGRAM_OFFICER_NAME: PERSAUD, ERIC

PROJECT_TERMS: Address;Adult;Area;Awareness;career;Career Choice;career development;Caring;chemical responder;climate change;Collaborations;Communities;Competence;Critical Thinking;Dangerousness;Data;Development;disability;Disadvantaged;disaster resilience;Disasters;Disease;Ebola;Education;Educational Curriculum;Educational process of instructing;Emergency response;emergency service responder;Emergency Situation;Employment;Employment Opportunities;Environmental Health;Evaluation;Funding;Generations;Harm Reduction;hazard;hazardous materials worker;Hazardous Substances;Hazardous Waste;Hazardous Waste Operations and Emergency Response;Hazardous Waste Sites;Health;Health Hazards;Health Personnel;health training;Hour;Human Resources;Hurricane;Immigrant;Individual;Injury;instructor;Knowledge;Low income;member;Migrant;minority communities;Morbidity - disease rate;mortality;Municipalities;National Institute of Environmental Health Sciences;New Jersey;New York;New York City;occupational health/safety;operation;opioid epidemic;peer learning;Police;Population;Poverty;prevent;Prevention;programs;Public Health;Public Health Schools;Puerto Rico;Readiness;Recording of previous events;response;Risk;Safety;Site;skills;Source;Strategic Planning;Target Populations;Techniques;Training;Training Programs;Underemployment;Unemployment;United States Virgin Islands;Universities;volunteer;Work;worker safety;Workplace

PROJECT_TITLE: Hazardous Materials Worker Health and Safety Training


NIH_SPENDING_CATS: Prevention

PROJECT_TERMS: Academia;Address;Adult;climate change;Communities;Competence;Critical Thinking;Dangerousness;Data;Development;disability;Disease;Education;Educational Technics;Emergency response;Emergency Situation;Environmental Engineering technology;Environmental Pollution;Evaluation;Excision;Exposure to;Generations;Goals;hazard;hazardous materials worker;Hazardous Substances;Hazardous Waste Operations and Emergency Response;Hazardous Waste Sites;Health;Injury;Knowledge;member;Methods;Morbidity - disease rate;mortality;National Institute of Environmental Health Sciences;New Jersey;New York;occupational health/safety;Occupations;peer learning;Police;Population;prevent;process improvement;programs;Public Health Schools;Public Sector;Puerto Rico;Recording of previous events;resilience;restoration;Risk;Safety;safety engineering;skills;Specialist;Target Populations;Training;Training Programs;Transportation;Underserved Population;United States Virgin Islands;Universities;Work;Workplace

PROJECT_TITLE: Hazardous Materials Worker Health and Safety Training- HWWTP


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The encephalitic, arthropod-borne alphaviruses including Venezuelan, eastern and western equine encephalitis viruses can cause fatal disease in humans and equines. There are no licensed human vaccines or antiviral drugs for the alphaviruses and the trivalent veterinary vaccine, given against VEEV, EEEV and WEEV, is poorly immunogenic, requiring frequent boosts. Together, these alphaviruses possess potential for use in biowarfare/bioterrorism and also present a threat for large-scale outbreaks. Based upon recent advances in understanding of the virulence mechanisms of each of these viruses, we propose to generate highy attenuated, immunogenic and stable live attenuated vaccines that can be used either as veterinary or human vaccines. We will test the possibility of using them as single virus formulations or as multivalent formulations against the encephalitic alphaviruses.

PI_NAMEs: KLIMSTRA, WILLIAM B (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: adaptive immune response;Address;Aerosols;Alpha Virus;Animal Disease Models;Animals;Anti-viral Agents;Anti-viral Therapy;Antibody Response;Antigen Presentation;Arboviruses;arthropod-borne;Attenuated;Attenuated Vaccines;attenuation;Biological Warfare;Bioterrorism;blind;Competence;cross immunity;Culicidae;cytokine;Death Records;design;Development;Disease;Disease Outbreaks;Domestic Animals;Dose;Eastern Equine Encephalomyelitis;Encephalitis;Encephalitis Viruses;Equus caballus;Evaluation;Formalin;Formulation;Genetic;Genome;Human;Imaging Techniques;Immune;Immunization;Immunize;immunogenic;immunogenicity;Immunologic Stimulation;In Vitro;in vivo;Inactivated Vaccines;Individual;Infection;Injections;Innate Immune Response;Licensing;Mediating;Mus;Mutagenesis;mutant;Mutation;next generation;Nucleotides;Pathogenicity;preclinical study;preservation;Process;protective efficacy;Reporter;Risk;Route;Safety;Techniques;Technology;Testing;Time;transmission process;Tropism;Vaccinated;vaccine access;vaccine candidate;Vaccine Design;vaccine development;vaccine efficacy;vaccine evaluation;vaccine formulation;vaccine strategy;Vaccines;Venezuelan;Venezuelan Equine Encephalitis Virus;Virulence;Virus;Virus Replication;Western Equine Encephalitis Virus

PROJECT_TITLE: An Informed Approach to Live Attenuated Vaccines against Encephalitis Alphaviruses

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Not Applicable per RFA-ES-19-003

PROJECT_TERMS: Academic Training;Adult;Advocacy;apprenticeship;Area;career;Career Ladders;career preparation;Certification;Chinese American;Communities;Community Health;Community Health Aides;community organizations;community partnership;Competence;County;Critical Thinking;curriculum enhancement;Cypress;Dangerousness;Data;design;Development;Education;Educational Curriculum;Enrollment;Environment;environmental disparity;Environmental Exposure;Environmental Health;environmental justice;Evaluation;Event;Exposure to;Flushing;Frequencies;Funding;Geographic Locations;Goals;Grant;Hazardous Substances;Hazardous Waste;Health;health disparity;health plan;Hospitals;Hour;Immigrant;Immigrant worker;Individual;Industry;Island;Job Ladders;Justice;Knowledge;Life;Link;literacy;Low income;Low Income Population;Marketing;Medical center;Methods;metropolitan;Minority;minority communities;Monitor;neighborhood disadvantage;New Jersey;New York;New York City;Occupational Exposure;Occupational Health;Occupations;outreach;Participant;peer learning;Perinatal;Policy Maker;Presbyterian Church;prevent;Prevention;Procedures;programs;Public Health;Recording of previous events;Recovery;recruit;Reduce health disparities;remediation;resilience;Safety;Science;screening;skills;Steel;Students;Target Populations;Technology;Training;Training Programs;U-Series Cooperative Agreements;Underemployment;underserved community;Unemployment;Urban Health;vulnerable community;Vulnerable Populations;Work;Workplace;Youth

PROJECT_TITLE: Hazardous Materials Worker Health and Safety Training Cooperative Agreement ECWTP


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: The myelin sheath surrounding axons is essential for the proper function of the nervous system and its disruption causes many devastating diseases including multiple sclerosis. G protein coupled-receptors (GPCRs) are excellent therapeutic targets. Here, we propose to characterize how adhesion GPCR GPR56 mediates cell-cell communication during central nervous system myelin development.

PI_NAMEs: PIAO, XIANHUA  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Actins;ADGR1 gene;Adhesions;Agonist;antagonist;Attention;Axon;Bilateral;Binding;Biology;Biotinylation;Brain;Cell Communication;Cell Proliferation;Cells;Cellular biology;cellular development;Cellular Morphology;Central Nervous System;Coculture Techniques;Corpus Callosum;Data;Defect;Demyelinating Diseases;design;Development;Disease;Expression Profiling;F-Actin;Failure;Family;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic;Glutaminase;Human;In Vitro;in vivo;inhibitor;Injury;Laminin;Ligands;loss of function mutation;Mediating;member;Membrane;Microglia;Microgyria;Modeling;mouse model;Multiple Sclerosis;Mus;Myelin;Myelin Sheath;myelination;Natural regeneration;Nervous System;nervous system development;Nervous System Disorder;Nervous System Physiology;Neuroglia;new therapeutic target;novel;novel therapeutics;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Optic Nerve;Pathway interactions;Pattern;pharmacologic;Play;polymerization;Polymers;precursor cell;Process;protein expression;Proteins;Proteomics;Publishing;remyelination;repaired;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Slice;stem cell expansion;Testing;therapeutic target;transglutaminase 2;Work;Zebrafish

PROJECT_TITLE: Adhesion G Protein-Coupled Receptors in CNS Development and Regeneration


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Prevention

PROJECT_TERMS: Academia;Address;Adult;Anthrax disease;Awareness;Caring;chemical responder;Collaborations;community organizations;Competence;Critical Thinking;Dangerousness;Data;Development;disaster resilience;Disasters;Disease;Ebola;Education;Educational Curriculum;Emergency medical service;emergency preparedness;Emergency Situation;Evaluation;Event;experience;first responder;flexibility;Goals;hazard;hazardous materials worker;Hazardous Substances;Hazardous Waste Operations and Emergency Response;Health;Health Hazards;Health Personnel;high risk;Hospitals;Hour;Human Resources;Hurricane;influenza outbreak;Injury;interdisciplinary approach;Knowledge;Knowledge acquisition;Language;language training;Letters;man-made disasters;meetings;member;Mental Health;Migrant;Modeling;Naloxone;National Institute of Environmental Health Sciences;Natural Disasters;neighborhood safety;New Jersey;New York;occupational health/safety;operation;Opioid;peer learning;peer support;Policy Developments;prevent;Prevention;Prevention approach;programs;Provider;Public Health Schools;Public Sector;Publishing;Puerto Rico;Readiness;Recording of previous events;resilience;Resources;response;Safety;skills;Spanish;Spanish/English;Substance abuse problem;Target Populations;Techniques;Trainers Training;Training;Training Programs;treatment center;United States Virgin Islands;Universities;volunteer;Work;Workplace;ZIKA

PROJECT_TITLE: Hazardous Materials Worker Health and Safety Training- HDPTP


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases;Lung

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Public Health Relevance Statement Dendritic cells (DC) are professional antigen presenting cells that serve critical roles in both innate and adaptive immune responses. This project investigates how DC focally deliver cytokines like interleukin 33 to T cells for shaping the inflammatory vs. anti-inflammatory responses generated within the respiratory mucosa through mechanisms dependent upon the enigmatic pore-forming protein Perforin-2.

PI_NAMEs: HERBERT, DE'BROSKI R (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Acute;adaptive immune response;Address;Adopted;airborne allergen;Airway Disease;Anti-Inflammatory Agents;Antigen-Presenting Cells;Antigens;Automobile Driving;B-Lymphocyte Subsets;Bacteria;Biochemical;Biological Assay;Bone Marrow;Cell Communication;Cell Death;Cell membrane;Cell Physiology;Cell Shape;Cells;Cellular biology;Chimera organism;chromatin immunoprecipitation;Chronic;chronic inflammatory disease;chronic rhinosinusitis;cytokine;Cytolysis;Cytoplasm;Data;Dendritic Cells;Development;Disease;draining lymph node;experimental study;Exposure to;Family;FOXP3 gene;GATA3 gene;Genes;Genetic Transcription;Growth Factor;helminth infection;Helminths;Human;IFNAR1 gene;Immunity;immunoregulation;Immunosuppression;Impairment;Infection;Inflammation;Inflammatory;Inflammatory Response;Influenza A virus;Inhalation;Innate Immune Response;Interferons;Interleukin-1;Interleukins;IRF4 gene;ITGAX gene;Location;Macrophage;mass spectrometric imaging;Mass Spectrum Analysis;Mediating;Mediator;Membrane;microbicide;Molecular;mouse model;Mucous Membrane;Mus;mutant;Myelogenous;N-terminal;Nasal Polyps;Necrosis;novel;Operative Surgical Procedures;Parasites;pathogen;Pathway interactions;Patients;Peptide Signal Sequences;perforin 2;Phagolysosome;Population;prevent;programs;protein aminoacid sequence;Protein Secretion;Proteins;public health relevance;Reagent;receptor;Regulatory T-Lymphocyte;Reporting;respiratory infection virus;Respiratory Mucosa;respiratory pathogen;respiratory virus;response;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Specimen;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Testing;theories;Therapeutic Intervention;Tissues;trafficking;transcription factor;VDAC1 gene;Virus;Virus Diseases;Work

PROJECT_TITLE: Perforin 2 controls unconventional cytokine release from mucosal APC


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Narrative Health disparities in obesity begin in infancy and continue to worsen throughout the lifespan. Preventing rapid weight gain in infancy among communities of color and economically marginalized populations is a priority area of clinical research, and responsive parenting appears to be a promising prevention approach. Embedding a responsive parenting obesity prevention in a pediatric primary care setting that families are familiar and engaged with has the potential to bolster uptake and improve health outcomes.

PI_NAMEs: RYBAK, TIFFANY MARY (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 2 year old;3 year old;Address;Adherence;Adult;adverse childhood events;Advocate;Affect;Aftercare;Age;age group;Age Months;Anxiety;Appetitive Behavior;Area;attentional control;Behavioral;behavioral health;Black race;Body mass index;cardiometabolism;Caregivers;Caring;Child;Child Rearing;Childhood;Clinical Research;Clinical Trials;Color;Communities;comorbidity;comparative efficacy;comparison control;Control Groups;critical period;Cues;Cultural Sensitivity;Data;Development;Digestive System Disorders;disadvantaged background;Distress;Eating Behavior;Educational process of instructing;efficacious intervention;Enrollment;Ethnic Origin;Family;feeding;Feeding behaviors;Focus Groups;Food;Goals;Growth;Health;Health Care Costs;health disparity;Health Personnel;Healthcare;high risk;high risk infant;Hispanic;Home;Home visitation;improved;Incidence;Income;infancy;Infant;infant adiposity;infant temperament;innovation;Intervention;intervention delivery;Latinx;Length;Life;life span;Low income;lower income families;marginalization;marginalized population;Mediator;Medical;Modeling;modifiable risk;Not Hispanic or Latino;novel;Nurses;nutrition;Obesity;obesity in children;obesity prevention;obesity risk;Outcome;parenting intervention;Parents;Participant;Phase;pilot test;population health;Postpartum Depression;Poverty;prevent;Prevention;Prevention approach;Prevention program;Preventive care;preventive intervention;Primary Care;primary care setting;primary outcome;process evaluation;programs;Protocols documentation;Psychologist;Public Health;public health insurance;Race;Randomized, Controlled Trials;rapid weight gain;recruit;Reduce health disparities;Regulation;Research;Research Personnel;Research Project Grants;Risk;Risk Factors;satisfaction;Self Efficacy;Services;skills;Sleep;sleep behavior;Solid;Specialist;Stigmatization;Stress;therapy development;Time;tool;treatment adherence;treatment as usual;treatment effect;treatment group;trial comparing;uptake;Visit;Weight;Weight Gain;Well Child Visits;Youth

PROJECT_TITLE: A Novel Obesity Prevention Program for High-Risk Infants in Primary Care

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ORG_DEPT: ORTHOPEDICS

PHR: Cell- and matrix-mediated mechanisms drive the formation of tendon hierarchical structure necessary for proper mechanical function. Collagen XII, a fibril-associated collagen, is known to play a structural role in forming flexible bridges between collagen fibrils, and our recent data also indicate a novel role for collagen XII in tendon cell organization and communication. Using mouse models to spatiotemporally modulate collagen XII expression, our proposed studies will define the temporal roles of collagen XII in cell organization and matrix assembly during the phases of tendon development and healing, which is highly significant in both furthering our understanding of why tendons heal poorly and providing guidance for future therapies.

PI_NAMEs: DYMENT, NATHANIEL A.;SOSLOWSKY, LOUIS J (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 3-Dimensional;Actins;cell behavior;Cell Communication;Cells;Clonal Expansion;Collagen;Collagen Fiber;Collagen Fibril;Communication;Confounding Factors (Epidemiology);Data;Deposition;Development;Disease;Embryo;Embryonic Development;Exhibits;Extracellular Matrix;Fiber;Fibril-Associated Collagens;Fibroblasts;flexibility;Future;Gap Junctions;Gel;Goals;Growth;healing;Impaired healing;Impairment;improved;in vivo;Injury;innovation;intercellular communication;knock-down;Knock-out;Knockout Mice;Knowledge;Measures;Mechanics;Mediating;mouse development;mouse model;nanoscale;new therapeutic target;novel;Outcome;Pattern;Phase;Play;Population;Positioning Attribute;postnatal;postnatal development;Process;progenitor;Qualifying;repaired;response;response to injury;Role;Shapes;Smooth Muscle;spatiotemporal;Structure;tendon development;Tendon Injuries;Tendon structure;Testing;Time;Tissues

PROJECT_TITLE: Critical role of collagen XII in cell- and matrix-mediated mechanisms regulating acquisition of tendon structure and function in development and the injury response

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Comparative Effectiveness Research;Digestive Diseases;Health Services;Prevention;Primary Health Care;Rehabilitation;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE We are currently facing unprecedented challenges in survivorship care delivery, including serious gaps in survivorship care (e.g., underuse of guideline-recommended cancer surveillance services and underuse of recommended preventive care services); these issues are compounded by the growing population of cancer survivors and the predicted oncology workforce shortage. To address these issues, we will conduct a prospective cluster randomized trial of two models of cancer survivorship care in early-stage colorectal cancer and breast cancer survivors cared for in a community-based, integrated health care setting. We will test the efficacy of an embedded PCP model (experimental condition) in which survivorship-trained PCPs are embedded within an oncology practice, compared to the oncology physician model (usual care) that is the default condition in this healthcare system.

PI_NAMEs: HAHN, ERIN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: ETON, DAVID T

PROJECT_TERMS: Address;Aftercare;Age;Breast Cancer Risk Factor;Breast Cancer survivor;California;Cancer Detection;Cancer Model;Cancer Patient;cancer recurrence;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer therapy;cardiovascular risk factor;care coordination;care delivery;care systems;Caring;Chronic Disease;Cluster randomized trial;Colonoscopy;Colorectal Cancer;Communication;Communities;comorbidity;Complex;Computerized Medical Record;Data;Detection;Disease;disorder prevention;Effectiveness;efficacy evaluation;efficacy testing;Growth;Guidelines;health care settings;Healthcare;Healthcare Systems;Hospitalization;Hospitals;human old age (65+);improved;Individual;Institution;Integrated Health Care Systems;International;Knowledge;Late Effects;Lipids;Literature;Localized Disease;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;Managed Care;Measures;Medical;Medical center;Modeling;Nature;Newly Diagnosed;novel;Observational Study;Oncology;Outcome;Patient Outcomes Assessments;patient population;patient-clinician communication;Patients;Perception;Phase;Physicians;Pilot Projects;Population;preference;Preventive care;Primary Care;primary care provider;primary outcome;prospective;Provider;psychosocial;Quality of Care;Quality of life;randomized trial;Recommendation;Recurrence;Reporting;Research;Resources;Risk;Risk Management;risk stratification;screening;secondary outcome;Self Efficacy;Services;Structure;Survivors;survivorship;System;Testing;Time;Training;treatment as usual;trial comparing;urgent care;Vaccination;Work

PROJECT_TITLE: The EPICS (Engaging Primary care in Cancer Survivorship) study: A trial of novel models of care for cancer survivors


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The work proposed will lead to scientific understanding of visuomotor functions in two areas of the human cortex, the posterior parietal cortex and primary motor cortex. The results will have direct relevance to the development of neuroprosthetic medical devices that can use the complimentary features of both areas. Such devices can help people with severe paralysis from spinal cord lesion and other traumatic accidents, peripheral neuropathies, amyotrophic lateral sclerosis, multiple sclerosis, and stroke.

PI_NAMEs: ANDERSEN, RICHARD A (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Accidents;Advanced Development;Algorithms;Amyotrophic Lateral Sclerosis;Anatomy;Area;arm;Ballistics;Behavioral;Body mass index;Body part;Brain;Brain region;California;Clinical Trials;Code;Cognitive;Complex;Computers;Conduct Clinical Trials;Contralateral;Data;design;Development;Devices;Electrodes;experimental study;FDA approved;Freedom;Future;Goals;Hand;Healthcare;Hospitals;Human;Implant;improved;Individual;Ipsilateral;Joints;Knowledge;Limb structure;Los Angeles;Medical Device;medical schools;Memory;Microelectrodes;Motor;motor behavior;Motor Cortex;Movement;Multiple Sclerosis;neural;neural prosthesis;Neurons;neurophysiology;neuroprosthesis;neuroregulation;neurosurgery;Outcome;Paralysed;Parietal Lobe;Participant;Patient Recruitments;Patients;Pattern;Performance;Peripheral Nervous System Diseases;Persons;Phase;Population;practical application;Property;Prosthesis;Prosthesis Design;Quadriplegia;Quality of life;Research;Research Design;Robotics;Sampling;Self-Help Devices;Side;Signal Transduction;Site;Specificity;Speed;Spinal Cord Lesions;Stroke;System;Technology;Testing;Time;Translating;Universities;Vision;Visual;visual motor;Work

PROJECT_TITLE: Visuomotor Prosthetic for Paralysis


ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Narrative. 15-Prostaglandin dehydrogenase (15-PGDH) degrades prostaglandin E2 (PGE2), a signaling molecule that promotes tissue repair and regeneration in multiple tissues. Therefore, inhibitors of 15-PGDH elevate PGE2 levels in tissue and may represent therapeutics for diseases characterized by ulceration or tissue damage. Here, we will use structure-based methods to design inhibitors of 15-prostaglandin dehydrogenase, determine the cell types that express and respond to 15-PGDH, and decipher the cytokine network that regulates tissue repair in response to PGE2.

PI_NAMEs: MARKOWITZ, SANFORD D.;PIEPER, ANDREW A;READY, JOSEPH M (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Acceleration;Adult;Alleles;analog;Backcrossings;Binding;Biochemistry;Biological Availability;Biotechnology;Biotinylation;Bleomycin;Bone Marrow;Bone Marrow Transplantation;Brain;Cell Fraction;cell type;Cells;Chemicals;cognitive function;Collaborations;Collection;Colon;Complex;conditional knockout;Cryoelectron Microscopy;cytokine;Cytokine Network Pathway;Cytokine Signaling;Data;Data Set;defined contribution;design;dextran sulfate sodium induced colitis;Dinoprostone;Disease;disease model;Drug Targeting;Engineering;Enzymes;Exclusion;Foundations;Future;Growth;Hematopoietic;Hippocampus;improved;in silico;in vivo;Individual;Inflammation;inhibitor;Injury;Joints;Kidney Diseases;Knock-out;knockout gene;Knockout Mice;Lead;Legal patent;Liver;LoxP-flanked allele;Macrophage;Maps;Mediating;Methods;Microglia;Modeling;molecular dynamics;mouse model;Mouse Strains;mRNA Expression;Mus;Neurons;Neurosciences;Oral;Organ;Oxidoreductase;Partial Hepatectomy;Pattern;Penetration;Peripheral;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;preservation;prevent;programs;Prostaglandins;protein expression;Proteins;Publications;Pulmonary Fibrosis;Recovery;Reporting;Research;Resolution;response;Rodent;Role;scaffold;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;small molecule;small molecule inhibitor;Specificity;Spleen;Stromal Cell-Derived Factor 1;structural biology;Structure;Techniques;Technology;Testing;Therapeutic;therapeutic target;three dimensional structure;Tissue Model;tissue regeneration;tissue repair;Tissues;Trauma;Traumatic Brain Injury;Ulcer;Ulcerative Colitis;Visualization

PROJECT_TITLE: Chemical, Structural and Cell-Signaling Interrogation of 15-Prostanglandin Dehydrogenase in Tissue Repair and Regeneration


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Back Pain;Genetics;Human Genome;Pain Research

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Low back pain experienced by millions of Americans is linked to degenerative disc disease, a condition that afflicts the spine. The goal of the proposal is to understand the cellular, metabolic, molecular and genetic factors contributing to disc degeneration using an animal model of spontaneous disc degeneration.

PI_NAMEs: RISBUD, MAKARAND V (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acute;Address;Affect;American;Animal Model;Back;Biological;burden of illness;Candidate Disease Gene;Canis familiaris;Cell Aging;Cell Physiology;Cell Survival;Cells;ChIP-seq;Chronic;Dasatinib;Data;Disease;early onset;Etiology;Excision;Exhibits;experience;Gene Expression;Genes;Genetic;genetic manipulation;Genetic Variation;genome wide association study;Genotype;Gerbils;Goals;Health;Health Status;Human;in vivo;Inbred Strains Mice;Inflammatory;Injury;insight;insurance claims;Intervention;Intervertebral disc structure;intervertebral disk degeneration;LG/J Mouse;Link;Low Back Pain;Measures;Metabolic;metabolic profile;Metabolism;metabolomics;Modeling;Modification;Molecular;mouse genome;mouse model;Mouse Strains;Mus;Mutation;Neck;Neck Pain;novel;nucleus pulposus;Opioid;opioid abuse;opioid mortality;Organ Culture Techniques;Pathogenesis;Pathology;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Pilot Projects;Population;Prevalence;prevent;Process;Publishing;Quantitative Trait Loci;Quercetin;regenerative;regenerative tissue;Reporting;Resolution;Risk Factors;Sand Rats;senescence;senescent cell;senolytics;SM/J Mouse;SNP array;Structure;Testing;therapeutic development;Time;Tissue Preservation;Tissues;trait;transcriptome;transcriptome sequencing;transcriptomics;Traumatic injury;Variant;Vertebral column;years lived with disability

PROJECT_TITLE: Targeting cell senescence in a novel model of spontaneous disc degeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ORG_CITY: WICHITA

ORG_DEPT: BIOLOGY

ORG_NAME: WICHITA STATE UNIVERSITY

ORG_STATE: KS

PHR: Narrative – Overall The goal of this research is to understand how variation in the number of oligosaccharide chains attached to follicle-stimulating hormone (FSH) affect fertility and other age-related issues in women, such as osteoporosis. This integrated research program will study FSH binding to its receptor, altering receptor oligomerization, activating different signal initiators, and stimulating different pathways both in cells and in whole organisms. The potential translational outcomes of this research is potentially improved drugs for infertility treatment or for ameliorating the bone-damaging effects of age-related increased FSH in the blood.

PI_NAMEs: BOUSFIELD, GEORGE R (contact)

PROJECT_TERMS: Address;Affect;Age;age effect;age related;aged;Aging;Agonist;Alternative Splicing;American;Antral;Arrestins;ATAC-seq;Back;Binding;Binding Sites;Biochemical;Biological;Blood;bone;Bone Density;bone loss;bone mass;Cell Line;Cell membrane;Cells;Circulation;Cleavage Under Targets and Release Using Nuclease;Confusion;Coupled;Coupling;CREB1 gene;Cryoelectron Microscopy;Cyclic AMP;Development;Disparate;Elderly;Engineering;Enzyme-Linked Immunosorbent Assay;Enzymes;Estrogens;Evaluation;Exhibits;Feedback;Female;female reproductive system;Fertility;Fertility Agents;fertility improvement;Follicle Stimulating Hormone;Follicle Stimulating Hormone Receptor;Funding;Genes;Genetic Models;Genetic Transcription;Genitourinary system;Glycoproteins;glycosylation;Goals;granulosa cell;Green Fluorescent Proteins;GTP-Binding Proteins;Health;Hormone Receptor;Hormones;Human;human female;hypothalamic pituitary ovarian axis;Impairment;improved;in vivo;Infertility;infertility treatment;inhibin;Injections;Knock-out;Knockout Mice;Knowledge;Laboratories;LH Receptors;Lifting;Ligand Binding;Link;Lipids;Location;Measures;Mediating;Membrane;Membrane Proteins;Menstrual cycle;Molecular;Molecular Conformation;monomer;Morbidity - disease rate;mouse genetics;mouse model;mullerian-inhibiting hormone;Mus;N-Glycosylation Site;nanodisk;Obesity;older women;Oligosaccharides;Organism;Osteoclasts;Osteoporosis;Outcome;Outcomes Research;Ovarian;Ovarian aging;Ovarian Granulosa Cell;Ovary;Pathway interactions;Pattern;Perimenopause;Physiological;Pituitary Gland;Play;Polysaccharides;Preparation;Process;Progesterone;programs;Protein Hormone Receptor;psychologic;Reagent;receptor;Receptor Activation;Reproduction;reproductive;reproductive senescence;Research;response;Role;Rotation;Side;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Steroid Receptors;Steroids;structural biology;Structure;System;Thyrotropin Receptor;Tissues;trafficking;transcription factor;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;translational potential;Uterine hemorrhage;Variant;vasomotor symptoms;Whole Organism;Woman;young woman

PROJECT_TITLE: The Aging Pituitary/Gonadal Axis


NIH_SPENDING_CATS: Aging

PROJECT_TERMS: Advisory Committees;Aging;Applications Grants;college;Colorado;Committee Members;Communication;Communities;Consultations;Data;Feedback;Fostering;Funding;Goals;Institution;Lead;London;Manuscripts;Medical;Medical center;meetings;Nebraska;Participant;Performance;performance site;Pituitary Gland;Play;Preparation;Principal Investigator;Program Reviews;programs;Progress Reports;Publications;Reporting;Research;Review Committee;Role;Schedule;symposium;United States National Institutes of Health;Universities;Wichita;Work

PROJECT_TITLE: Core A: Administrative Core


PI_NAMEs: MAY, JEFFREY V. (contact)

PROJECT_TERMS: Aging;Antibodies;Antigens;Area;Biochemical;Biological;Biological Assay;Capillary Electrophoresis;Cattle;Cell Differentiation process;Cell Line;Cell Physiology;Cells;Chinese Hamster Ovary Cell;comparative;Complex;Conditioned Culture Media;Cryopreserved Cell;design;Detection;Development;Enzyme-Linked Immunosorbent Assay;Estradiol;experimental study;Family suidae;Follicle Stimulating Hormone Receptor;Gene Expression;Genes;Glutamine;granulosa cell;Harvest;Hormones;Human;Human Follicle Stimulating Hormone;human model;Hybridomas;immunoaffinity chromatography;Immunologics;improved;In Vitro;in vivo;Individual;LH Receptors;Liquid substance;manufacturing run;Measures;Membrane;milligram;Modeling;Monitor;Monoclonal Antibodies;mouse model;Mus;mutant;Mutate;Oocytes;Ovarian;Ovarian Follicle;Pituitary Gland;Preparation;Procedures;Production;Progesterone;programs;Proteins;quality assurance;Quality Control;Radioimmunoassay;Rattus;Reagent;receptor;receptor binding;Receptor Mediated Signal Transduction;Recombinants;repository;Role;screening;Serum;Source;Specimen;steroid hormone;System;Systems Development;Testing;Testosterone;tool;Transfection;Ultrafiltration;uptake;urinary;Urine;Validation;Variant;vector;Western Blotting;Work

PROJECT_TITLE: Core B: FSH Glycoform Production, Purification, and Analysis


NIH_SPENDING_CATS: Aging;Burden of Illness;Clinical Research;Clinical Trials and Supportive Activities;Osteoporosis;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation;Women's Health Research

PHR: PROJECT NARRATIVE Public Health Relevance: Falls are common and devastating for long-term care residents, yet fall prevention strategies have been largely unsuccessful. This study examines a novel approach for maintaining/improving muscle health with a bone health agent that should pave the way for a falls/fracture prevention trial in this vulnerable cohort.

PI_NAMEs: GREENSPAN, SUSAN L (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: 3-Dimensional;absorption;Activities of Daily Living;Address;Adult;adverse outcome;age group;Attenuated;Biochemical;Biochemical Pathway;bone;Bone Density;bone health;bone loss;bone mass;Calendar;Cessation of life;cohort;Communication;Communities;comorbidity;comparison control;Controlled Clinical Trials;Creatine;Death Rate;Dependence;disability;Distal;Double-Blind Method;efficacy evaluation;efficacy testing;Elderly;Electronics;Enrollment;Event;Face;Fall prevention;fall risk;falls;Fracture;Frail Elderly;frailty;functional outcomes;GDF8 gene;Goals;Hand Strength;Health;high risk;Hip Fractures;Hip region structure;Hospitalization;human old age (65+);improved;Incidence;Individual;innovation;Institutionalization;Knee;Knowledge;Link;Long-Term Care;Measures;Mechanics;Mediating;Medical Care Costs;men;Meta-Analysis;Mobility decline;Molecular Target;Monitor;Morbidity - disease rate;mortality;Multicenter Trials;Muscle;Muscle function;muscle strength;Muscular Atrophy;N-terminal;neglect;Notification;novel;novel strategies;older adult;older men;older women;Oral;Osteocalcin;Osteopenia;Osteoporosis;osteoporosis with pathological fracture;Outcome;Participant;Pathway interactions;Patients;Peptides;Personal Satisfaction;Pharmaceutical Preparations;Physical Function;Pilot Projects;Polypharmacy;Population;portability;preservation;prevent;Prevention;Prevention strategy;Prevention trial;primary outcome;Procollagen Type III;public health relevance;Quality of life;Randomized;reduced muscle mass;Reporting;Research;Research Personnel;Safety;sarcopenia;sedentary;Serious Adverse Event;Site;skeletal;Soft Tissue Disorder;Spinal Fractures;statistics;Structure;success;symposium;Syndrome;System;Techniques;Telephone;Time;Translating;ultrasound;Vulnerable Populations;Woman;Zoledronic Acid

PROJECT_TITLE: Preserving Geriatric Muscle with an Osteoporosis Medication

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE: Overall Addiction is a chronic relapsing brain disorder, and understanding how the brain can go awry will speed the design of more effective therapies. The University of Minnesota has thriving communities of both NIDA-supported addiction researchers and biomedical technology innovators. By bringing these communities together, our Center for Neural Circuits in Addiction would drive innovative, high-impact research at the local and national level to help curtail this growing health problem.

PI_NAMEs: THOMAS, MARK JOHN (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Address;Adoption;Anatomy;Animals;base;Behavior;Biological;biomarker identification;Biomedical Technology;Brain;Brain Diseases;Brain region;Catalysis;cellular imaging;Chronic;Cognition;Collaborations;Communities;Complement;computational platform;connectome;Consumption;cost;craving;Custom;Data;Data Analyses;Data Collection;design;Development;Discipline;Drug Addiction;Economics;effective therapy;Endowment;Exhibits;Exposure to;Fiber;Fluorescence;Functional disorder;Funding;Future;Goals;Head;Health;Image;imaging facilities;imaging modality;Individual;Informatics;Information Dissemination;innovation;innovative technologies;Institution;interest;Interruption;Knowledge;Label;Leadership;Maps;Measures;mental function;Microscope;Mind;Minnesota;Mission;Modality;Molecular;Monitor;multimodality;National Institute of Drug Abuse;neural;neural circuit;Neurons;Neurosciences;Neurosciences Research;new technology;novel;novel therapeutics;optical imaging;Pattern;Pharmaceutical Preparations;Photometry;Pilot Projects;Positioning Attribute;Prevention;Process;promoter;Reagent;Relapse;Research;Research Personnel;Resources;Serotyping;Signal Transduction;Specific qualifier value;Speed;Substance Use Disorder;Techniques;Technology;Testing;tool;Training and Education;United States National Institutes of Health;Universities;vector;Viral;Virus;Work

PROJECT_TITLE: Center for Neural Circuits in Addiction


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PROJECT_TERMS: addiction;career;Collaborations;Communities;Consultations;Core Facility;Data Set;design;Development;Drug Addiction;Education;Education and Outreach;Ensure;Event;experience;Faculty;Funding;Goals;Heart;Individual;instrument;International;Measures;Medical;medical schools;member;Minnesota;Mission;National Institute of Drug Abuse;neural circuit;Neurosciences;operation;outreach;Physician Executives;Play;professor;recruit;Research;Research Personnel;Resources;Role;Science;Technology;tenure track;Training;Universities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: GUDA, CHITTIBABU  (contact)

PROJECT_TERMS: Aging;Archives;Area;ATAC-seq;Bioinformatics;bioinformatics tool;biological research;Cells;Characteristics;Chromatin;Cleavage Under Targets and Release Using Nuclease;cloud based;Collaborations;Communities;computer infrastructure;Core Facility;Cryoelectron Microscopy;Custom;Data;data access;Data Analyses;data analysis pipeline;Data Set;Databases;differential expression;Distant;Educational workshop;Environment;Epigenetic Process;experimental analysis;experimental study;Family suidae;Gene Expression;Gene Expression Profile;gene product;Generations;Genes;Genomics;Geographic Locations;glycosylation;Goals;Human;Human Resources;Image;Individual;innovation;Link;Location;Maps;Mass Spectrum Analysis;Medical center;Metadata;Methods;miRNA expression profiling;Modeling;Multiomic Data;multiple omics;Mus;Nature;Nebraska;next generation sequencing;Pathway Analysis;Pathway interactions;Pituitary Gland;Polysaccharides;programs;protein expression;Proteomics;Protocols documentation;Rattus;Research;Research Project Grants;Resources;Sampling;Science;searchable database;Signal Transduction;single-cell RNA sequencing;Site;Structure;success;Techniques;Technology;Testing;Tissues;tool;Training;Training Activity;Training and Infrastructure;training project;transcriptome sequencing;transcriptomics;Universities;Validation;Variant;Visualization;web interface;web portal;web services;webinar

PROJECT_TITLE: Core C: Bioinformatics and Genomics Core


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Gene Therapy;Genetics;Neurosciences;Substance Misuse

PI_NAMEs: WICKMAN, KEVIN D (contact)

PROJECT_TERMS: addiction;adeno-associated viral vector;adenovirus mediated delivery;Animals;Antibodies;Area;arm;base;Behavior;Capsid;cell type;Cells;cellular imaging;Communities;connectome;Coupled;Custom;Data;data acquisition;Data Analyses;Dependovirus;design;DNA;Ectopic Expression;Elements;Encapsulated;Engineering;Enterobacteria phage P1 Cre recombinase;Evaluation;Feedback;FLP recombinase;Future;Gene Delivery;Generations;Genome;Goals;improved;innovation;insight;interest;Investigation;Investments;Life;Maps;Measures;Mediating;Medical;Methodology;Minnesota;Mission;Modeling;multimodality;Mus;Nervous System;neural circuit;neuronal excitability;Neurons;Neurosciences;Neurosciences Research;nonhuman primate;Nucleic Acid Regulatory Sequences;Performance;permissiveness;Population;Process;Production;programs;promoter;Property;Proteins;Quality Control;Rattus;receptor;recombinase;Reporting;Research;research and development;Research Personnel;Research Project Grants;Risk;scaffold;screening;Serotyping;Services;skills;Specific qualifier value;Specificity;success;Surface;synergism;Tertiary Protein Structure;Tissues;tool;transduction efficiency;Transgenes;Transgenic Animals;Transgenic Organisms;Tropism;Universities;vector;Vertebral column;Viral;viral gene delivery;Viral Vector;Virus;virus tropism

PROJECT_TITLE: Viral Innovation Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Immunization;Infectious Diseases;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: GALVESTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE Research on emerging viruses and arthropod-borne viruses requires diverse collections of virus strains as well as antibodies, antigens and other reagents that cannot be made at many scientific institutions. The World Reference Center for Emerging Viruses and Arboviruses (WRCEVA), established over 5 decades ago, maintains a comprehensive, diverse collection of over 8,000 virus strains in 21 families, as well as related reagents to enable emerging virus research worldwide.

PI_NAMEs: WEAVER, SCOTT C (contact)

PROGRAM_OFFICER_NAME: WOODSON, SARA ELAINE

PROJECT_TERMS: 2019-nCoV;Adopted;Aedes;African;anthropogenesis;Antibodies;antibody diagnostic;Antigenic Diversity;Antigens;Arboviruses;arthropod-borne;Asia;biodefense;Bioterrorism;bioweapon;Chikungunya virus;Clinical;Collaborations;Collection;Communities;Complementary DNA;Coronavirus;COVID-19;COVID-19 pandemic;cross immunity;Cryoelectron Microscopy;Culicidae;Databases;deep sequencing;Dengue;Development;Diagnostic;Ebola virus;Ecology;effective intervention;Electron Microscopy;Emergency response;Emergency Situation;emerging virus;Epidemic;Epidemiology;Evolution;Family;Flavivirus;Foundations;Funding;Generations;Genetic Variation;Genomics;Goals;Growth;Health;Human;human disease;Immune Sera;improved;In Vitro;in vivo;Infection;Institution;International;Intervention;Laboratories;Location;Methods;Middle East Respiratory Syndrome Coronavirus;National Institute of Allergy and Infectious Disease;new outbreak;new pandemic;new technology;New York;next generation sequencing;novel;outbreak response;pandemic disease;Pathogenesis;Pattern;Phenotype;Phylogenetic Analysis;Play;Principal Investigator;programs;Public Health;Qualifying;Reagent;Recording of previous events;repository;Research;Research Support;Role;Sampling;Scientist;Serology;Source;South America;Taxonomy;Technology;Testing;Therapeutic;Training;transmission process;trend;United States National Institutes of Health;Universities;Vaccine Design;vaccine development;Vaccines;vector transmission;Viral;Viral Genome;Virus;Virus Diseases;virus identification;Visit;Yellow Fever;Yellow fever virus;ZIKA;Zoonoses


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE The number of individuals with clinical Alzheimer's disease (AD) is rapidly increasing worldwide due to aging of the population, but current cognitive measures lack sufficient sensitivity and specificity to detect subtle decline within the preclinical phase. There is a critical need for tools that are sensitive to AD neuropathology during the preclinical phase that are low-cost, high-access, and fast to administer that can be used across educationally, linguistically, and culturally diverse older individuals. The goal of this project is to identify metrics for semantic impairment in diverse individuals that correlate with AD neuropathology and predict clinical decline.

PI_NAMEs: VONK, JET M.J. (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Adult;Age;age effect;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Amyloid;Amyloid beta-Protein;Animals;apolipoprotein E-4;Area Under Curve;autosome;Biological Markers;Black race;Canis familiaris;Caregivers;Categories;Clinical;clinical diagnosis;clinical predictors;Clinical Research;Cognitive;cognitive testing;cohort;cost;Data;Dementia;Demographic Factors;demographics;Diagnosis;diagnostic accuracy;early detection biomarkers;Early Diagnosis;Education;Epidemiology;Episodic memory;Equation;Ethnic Origin;Ethnic Population;experience;Foundations;Frequencies;Gender;gender difference;Genes;Goals;Hippocampus;Hispanic;Iguanas;imaging biomarker;Impairment;Individual;Inherited;Intervention;Intervention Trial;Investigation;Knowledge;Language;Length;lexical;Linear Models;Linguistics;Longitudinal cohort;Magnetic Resonance Imaging;Maps;Measures;Medial;Memory impairment;Modeling;mutation carrier;Names;neuroimaging marker;neuropathology;Neuropsychology;non-demented;normal aging;novel;older adult;Older Population;Outcome;Parietal;Participant;Patients;Performance;Persons;Phase;Population;Positron-Emission Tomography;pre-clinical;Predictive Value;Process;prognostic model;programs;Psycholinguistics;Race;racial population;Research;Semantic memory;semantic processing;Semantics;Sensitivity and Specificity;sex;Spanish;Specificity;Statistical Data Interpretation;Symptoms;Testing;Thinness;Time;tool;Training;trait;Translating;Universities;Variant;Walking;Work

PROJECT_TITLE: Preclinical markers of Alzheimer's disease using psycholinguistic semantic measures


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

PI_NAMEs: MERMELSTEIN, PAUL G (contact)

PROJECT_TERMS: 3-Dimensional;addiction;Algorithms;Anatomy;Antibodies;Atlases;base;Behavior;Brain;brain based;brain circuitry;Brain imaging;Brain Mapping;Brain region;Central Nervous System;Collection;Communities;computational platform;Computer software;connectome;Custom;Data;data acquisition;Data Analyses;data handling;data repository;Data Set;Dedications;design;Development;Disadvantaged;Drug Addiction;Effectiveness;Equipment;equipment acquisition;experimental study;Goals;Grant;Histology;Image;imaging approach;imaging facilities;imaging modality;imaging system;improved;Individual;Informatics;Infrastructure;innovation;instrumentation;Label;Laboratories;large datasets;Medical;member;method development;Methodology;Methods;Microscopy;Minnesota;Mission;Modernization;Mus;Nervous System;neural circuit;Neuroanatomy;Neuroglia;Neurons;new technology;nonhuman primate;Optics;Pathway interactions;Penetration;Photobleaching;portability;Procedures;Protocols documentation;Publishing;Rattus;Refractive Indices;Registries;repository;Research Personnel;Resolution;Resources;Scanning;Services;Software Design;software development;Specificity;Standardization;Structure;Supercomputing;Techniques;Technology;technology development;Three-Dimensional Imaging;tissue fixing;tissue preparation;Tissues;Universities;Viral

PROJECT_TITLE: Structural Circuits Core


PI_NAMEs: KUMAR, T. RAJENDRA  (contact)

PROJECT_TERMS: Acceleration;Affinity;Age;age related;age related changes;Aging;aging related;Alleles;Antibodies;Binding;Biochemical;Biological;Biological Process;bone;bone aging;bone loss;Cells;Clinical;Collaborations;Cre driver;Densitometry;Elements;Engineering;enzyme pathway;Epidemiology;ESR1 gene;Estrogen decline;Estrogen Receptors;Estrogens;Estrus;Event;Face;Female;Follicle Stimulating Hormone;Follicle Stimulating Hormone Receptor;folliculogenesis;gel electrophoresis;Genes;Genetic;genetic approach;Genetic Engineering;Genetic Models;Germ Cells;glycosylation;Goals;Gonadal structure;Health;Heterogeneity;Histologic;hormonal signals;hormone analog;Hormones;Human;Human Follicle Stimulating Hormone;human old age (65+);imaging study;improved;In Vitro;in vivo;Individual;Intervention;Knock-out;Knockout Mice;life span;Link;Mediating;Menstrual cycle;mouse model;Mus;Mutant Strains Mice;Mutation;novel;novel therapeutics;Osteoclasts;Ovarian;Ovarian aging;Ovarian Follicle;Ovariectomy;Ovary;Perimenopause;Phenotype;Physiological;Physiology;Pituitary Gland;Play;Polysaccharides;Postmenopause;preservation;Prevention;Production;promoter;Recombinant Follicle Stimulating Hormone;reproductive;RNA;Role;Signal Pathway;Signal Transduction;Sorting;Specificity;sugar;Testing;Tetanus Helper Peptide;Tissues;transcriptome sequencing;Transgenes;Transgenic Organisms;Urine;Variant;Woman;X-Ray Computed Tomography;young woman

PROJECT_TITLE: Project 1: Functional Analysis of Age-Specific FSH Analogs Using Genetically Altered Mice


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: PROJECT NARRATIVE CSHL Laboratory Course in Advanced Techniques in Molecular Neuroscience This application seeks funds to support an advanced neuroscience lab-based short course at Cold Spring Harbor Laboratory, New York. The course aims to provide advanced training in state-of- the-art molecular approaches in neuroscience. Trainees include advanced graduate students, postdoctoral researchers and young faculty from throughout the United States and abroad. The selection process for entry into these courses is highly competitive, and trainees leave the course armed with new techniques, know-how and potential collaborators to apply to their own areas of research. A significant proportion of trainees subsequently undertake basic or applied research in diseases of mental health and/or neurological disorders. Methods and concepts taught in the course are disseminated to the wider research community through the publication of laboratory manuals and online resources.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Applied Research;Area;astrocyte progenitor;ATAC-seq;Attention;Bacterial Artificial Chromosomes;Basic Science;Binding;Biological Assay;Cell Culture Techniques;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;Course Content;design;Detection;Disease;Educational process of instructing;Electrophysiology (science);Engineering;Ensure;Environment;Exercise;experience;Faculty;Female;forging;Funding;Future;gene delivery system;genome editing;genome-wide;graduate student;Home;Image;Immunoprecipitation;in vivo;Individual;Institution;instructor;interest;Laboratories;laboratory curriculum;laboratory manuals;lecturer;Mainstreaming;medical specialties;member;Mental Health;Messenger RNA;Methodology;Methods;mid-career faculty;Molecular;Molecular Neurobiology;nerve stem cell;Nervous System Disorder;neural;Neurobiology;Neurosciences;Neurosciences Research;New York;online resource;Participant;Pharmacology;Physicians;Postdoctoral Fellow;Preparation;Process;programs;protein crosslink;Publications;Reaction;recruit;Reporting;Research;Research Personnel;RNA;RNA Binding;Role;Scientist;Series;Specific qualifier value;Students;Techniques;Time;Tissues;tool;Training;Training Programs;transcription factor;Transgenic Organisms;Translating;Underrepresented Minority;United States;Update;vector;Viral Vector;Work

PROJECT_TITLE: CSHL Advanced Techniques in Molecular Neuroscience Course


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: EBNER, TIMOTHY J (contact)

PROJECT_TERMS: 3-Dimensional;addiction;Address;Aging;analytical tool;Animals;Behavior;Brain;Brain imaging;cellular imaging;Cerebral cortex;Chronic;Cognition;Communities;Computer software;computerized tools;cost;Data;Decision Making;design;Development;Disease;Dorsal;Elements;Engineering;Equipment;experimental study;Failure;Fiber;Free Will;Head;Human Resources;Image;Image Enhancement;imaging capabilities;Imaging Device;imaging modality;Imaging Techniques;Imaging technology;improved;in vivo;in vivo imaging;Individual;Laboratories;learning network;Magnetic Resonance Imaging;Magnetism;manufacture;Methods;Microscope;miniaturize;Minnesota;Modeling;Modernization;Monitor;mouse model;Movement;Mus;National Institute of Drug Abuse;nervous system imaging;Nervous System Physiology;neural;neural circuit;neuroimaging;Neurons;Neurosciences;Neurosciences Research;novel therapeutics;optical imaging;Optics;Pattern;Perception;Photometry;Photons;Process;Productivity;programs;Rattus;Relapse;Research;Research Infrastructure;Research Personnel;Residual state;Resolution;Resources;Services;spatiotemporal;Speed;Structure;Surface;Techniques;Technology;Time;tool;Training;Universities;Visualization;Work

PROJECT_TITLE: Imaging Cells during Behavior Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Complementary and Integrative Health;Heart Disease;Physical Activity;Prevention

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative This project ultimately aims at optimizing the non-invasive monitoring of exercise therapy in heart failure patients to potentially improve outcome. The research strategy is designed to systematically develop an innovative cardiac diffusion tensor MRI method that overcomes major shortcomings of the conventional methods and aims at immediate clinical translation. Successful completion of this project will result in a clinically robust cardiac diffusion tensor MRI method that can effectively monitor the efficacy of exercise therapy and potentially improve treatment of heart failure.

PI_NAMEs: NGUYEN, CHRISTOPHER T (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: 3-Dimensional;Address;Aerobic;Affect;Agreement;Architecture;Biological Markers;Biopsy;Blood;Bone Marrow;Cardiac;Cardiac Myocytes;cardioprotection;Cell Therapy;Cessation of life;Clinical;clinical translation;cohort;Compensation;Consensus;coronary fibrosis;Data;denoising deep learning;design;Detection;Diffusion;Diffusion Magnetic Resonance Imaging;Dose;Echocardiography;effective therapy;Effectiveness;Electrocardiogram;Evaluation;Exercise;Exercise Therapy;exercise training;Exhibits;Family suidae;Fiber;Fluorescence Microscopy;functional loss;Genetic Transcription;Heart failure;heart function;Histology;improved;improved outcome;in vivo;Incidence;Individual;innovation;insight;Institution;Light;Magnetic Resonance Imaging;Maps;Measures;Methodology;Methods;Monitor;Motion;MRI Scans;multitask;Mus;Myocardial;Myocardial Infarction;Myocardium;new technology;non-invasive imaging;non-invasive monitor;novel;Outcome;Pacemakers;Patients;Pattern;Pharmaceutical Preparations;pre-clinical;preclinical study;preservation;Prevalence;Prognostic Marker;prognostic tool;prognostic value;Property;reconstruction;Reproducibility;Research;RNA marker;Scanning;sedentary;Signal Pathway;Slice;Structure;Tachycardia;Techniques;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Time;Tissues;tomography;tool;Translating;Treatment outcome;United States

PROJECT_TITLE: Serial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRI

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


PI_NAMEs: HAYDEN, BENJAMIN Y (contact)

PROJECT_TERMS: addiction;Address;Anatomy;Animal Model;Animals;Behavior;Behavioral;behavioral phenotyping;Brain;Brain region;cellular imaging;Chronic;Cocaine;Collection;Communication;Communities;computer infrastructure;connectome;connectome data;Data;data integration;Data Set;Databases;Development;diffusion weighted;Drug Exposure;drug seeking behavior;Exposure to;Extramural Activities;Functional Magnetic Resonance Imaging;Generations;Genetic Recombination;Heroin;Human;improved;Individual;Infrastructure;innovation;insight;International;Light;Link;Maps;Methodology;Methods;Minnesota;Mission;Monkeys;multimodality;Mus;neural;neural circuit;neuroimaging;Neurons;nonhuman primate;novel;Online Systems;Opioid;optical imaging;Pattern;Pharmaceutical Preparations;Population;repository;Research;Research Personnel;Resources;response;Rest;Rodent;Scanning;Scientist;searchable database;Self Administration;Source;Standardization;Stimulant;Time;Universities;usability;Visualization;web platform;Work

PROJECT_TITLE: Addiction Connectome Core


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Electronic Nicotine Delivery Systems;Neurosciences;Prevention;Stroke;Tobacco;Tobacco Smoke and Health

ORG_CITY: LUBBOCK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

PHR: Project Narrative:  It is known that metformin (MF), a widely prescribed, firstline anti-diabetic drug, can positively modulate lipid, metabolic and inflammatory profiles. Interestingly, recent reports show that MF treatment before and after ischemic injury reduces stress and inhibits inflammatory responses. Recent published work by our group and as well as current preliminary data reveal that MF promotes the activation of counteractive mechanisms which drastically reduce tobacco smoke (TS) and e-cigarette (e-Cig) toxicity at both the brain and cerebrovascular levels, protects BBB integrity, and improves stroke outcome. Ultimately our data suggest that repurposing MF could provide a suitable prophylactic and/or post stroke therapeutic agent to be utilized for a high risk, stroke-prone populations of smokers and possibly early stage former smokers.  To this end, the goal of our current research endevour is to understand further the mechanisms and extent to which metformin can prevent/reduce BBB damage and subsequent ischemic stroke injuries in high risk populations of smokers and vapers. We are concurrently exploring the inhibition of pathological mechanisms related to the dysregulation of Nrf2, which is similarly involved in TS/e-Cig cerebrovascular impairments.

PI_NAMEs: ABBRUSCATO, THOMAS J (contact);CUCULLO, LUCA

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Address;Animals;Anti-diabetic Drugs;artery occlusion;Attenuated;Behavioral;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;blood-based biomarker;Brain;brain endothelial cell;Brain Injuries;brain tissue;Cardiovascular system;Caring;Carotid Arteries;Cell Separation;Cerebral Ischemia;cerebrovascular;Chronic;chronic stroke;Clinical;Clinical Research;comorbidity;Data;Disease;Dose;Edema;effectiveness evaluation;Electronic cigarette;electronic liquid;Endothelium;environmental tobacco smoke exposure;Evaluation;Female;fluoro jade;former smoker;Gender;Goals;Grant;Health;Hemorrhage;high risk;high risk population;Histologic;Hour;Impairment;improved;In Vitro;in vivo;Infarction;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;Investigation;Ischemia;Ischemic Brain Injury;ischemic injury;Ischemic Stroke;Laboratories;Link;Lipids;male;Measurement;Mediating;Meta-Analysis;Metabolic;Metformin;Mitochondria;Molecular;Molecular Target;mortality;Mus;Neurologic;Neurons;neuroprotection;never smoker;NF-kappa B;Nicotine;Nicotine Withdrawal;nuclear factor-erythroid 2;Outcome;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Pathologic;Pathway interactions;Plasma;Population;post stroke;preclinical study;prevent;prophylactic;Proteins;Publications;Publishing;Reactive Oxygen Species;Recovery;Reperfusion Injury;Reporting;Research;response;restoration;Risk;Risk Factors;Signal Pathway;Small Interfering RNA;Smoke;Smoker;Smoking;Stains;stress reduction;Stroke;stroke outcome;stroke risk;stroke therapy;System;Therapeutic;Therapeutic Agents;Thrombomodulin;Time;Tobacco smoke;tobacco smoke exposure;Tobacco smoking behavior;Toxic effect;treatment group;vaper;vaping;vapor;vascular endothelial dysfunction;vascular inflammation;Withdrawal;Woman;Work

PROJECT_TITLE: Repurposing Metformin to Offset Stroke Risk and Injury in Comorbid Populations of Smokers

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS-R]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: LOS ANGELES

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative  As pharmaceutical targets become more complex, organic methodologies that form complex carbon skeletons from simple precursors are especially desirable. The proposed research seeks to study classic carbon- –carbon bond forming methodologies and apply them in novel ways toward the synthesis of the complex hydrocarbon dodecahedrane. The chemistry developed in this proposal will provide insight into the synthesis of complex molecules from simple substrates, which constitutes basic research toward the furtherment of human health.

PI_NAMEs: MCDERMOTT CATENA, LUCA  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: 3-Dimensional;Alkenes;Area;Basic Science;Biochemistry;Carbon;carbon skeleton;chemical synthesis;Chemistry;Complex;Cyclization;design;Development;dimer;Drug Industry;functional group;fundamental research;Health;Human;human disease;Hydrocarbons;improved;insight;Investigation;Isomerism;Medicine;Methodology;Methods;molecular assembly/self assembly;National Institute of General Medical Sciences;novel;novel therapeutics;Organic Synthesis;Pentas;Pharmaceutical Preparations;Pharmacologic Substance;Phase;pi bond;Play;Polyenes;rapid technique;Reaction;Research;research study;Research Support;Role;Route;scaffold;Site;small molecule;Training;Validation;Variant

PROJECT_TITLE: Total Synthesis of Dodecahedrane via Carbon–Carbon Bond Forming Cascades


PROJECT_TERMS: addiction;Address;Award;Awareness;Behavior;brain tissue;cell type;cellular imaging;Collaborations;Communities;Complement;connectome;connectome data;Consultations;Creativeness;Data;Evaluation;experience;Faculty;Feedback;Fentanyl;Fostering;Funding;Goals;Grant;Individual;Industry;Infrastructure;innovation;Interneurons;Macaca;member;Minnesota;National Institute of Drug Abuse;neural circuit;novel;Nucleus Accumbens;Parietal;Pilot Projects;Policies;Positioning Attribute;Procedures;programs;Progress Reports;Recommendation;Reporting;Research;research data dissemination;Research Personnel;Research Project Grants;Schedule;Technical Expertise;translational potential;United States National Institutes of Health;Universities;Viral;web site;Work

PROJECT_TITLE: Pilot Projects Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: The proposed project will investigate the mechanisms by which NKT cells engineered to express a tumor-specific chimeric antigen receptor mediate anti-tumor activity against neuroblastoma, one of the most common and deadly type of cancer in children. The results may lead to new immunotherapeutic strategies and clinical trials in neuroblastoma and other types of pediatric and adult cancers.

PI_NAMEs: METELITSA, LEONID S (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: adaptive immune response;Address;Adult;anti-tumor immune response;Antigens;Applications Grants;Autologous;B lymphoid malignancy;cancer immunotherapy;cancer type;Cell Line;Cell Therapy;Cell Transplantation;Cells;cellular engineering;Cellular Metabolic Process;Characteristics;Child;Childhood;chimeric antigen receptor;chimeric antigen receptor natural killer cells;chimeric antigen receptor T cells;Clinical;Clinical Trials;Cytotoxic T-Lymphocytes;Data;Development;Elements;Engineering;Evaluation;exhaustion;experimental study;first-in-human;fitness;Frequencies;gain of function;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;Goals;high risk;Human;Immunotherapeutic agent;Immunotherapy;In Vitro;in vivo;Innate Immune Response;Interleukin-15;Investigation;Knowledge;Large T Antigen;loss of function;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Memory;Metabolic;metabolic fitness;Metabolism;Modeling;Molecular;Mus;Neoplasm Metastasis;neoplastic cell;Neuroblastoma;neuroblastoma cell;next generation;NK Cell Activation;overexpression;Pathologic;Pathway interactions;Patients;peripheral blood;Phase I Clinical Trials;Phenotype;pre-clinical;preclinical study;preservation;Primary Neoplasm;Proliferating;Property;Protocols documentation;Publications;Reporting;Research;Resistance;response;Role;SELL gene;Side;Simian virus 40;single-cell RNA sequencing;Site;Solid Neoplasm;System;T cell therapy;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;therapeutic target;tool;Toxic effect;Transactivation;transcription factor;Transcriptional Activation;Transgenic Organisms;tumor;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;WNT Signaling Pathway

PROJECT_TITLE: CAR NKT Cell Immunotherapy of Neuroblastoma

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Aging;Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Infertility;Women's Health Research

PI_NAMEs: DAVIS, JOHN S (contact)

PROJECT_TERMS: advanced maternal age;Affect;Affinity;Age;Aging;Apoptosis;ATAC-seq;Binding;Bioinformatics;Biological;Cell Differentiation process;Cell Line;Cell Physiology;Cell Proliferation;Cells;Child;Childbirth;Chromatin;Cleavage Under Targets and Release Using Nuclease;Coupled;CREB1 gene;Cyclic AMP-Dependent Protein Kinases;Data;Development;Diagnosis;diminished ovarian reserve;Employment;Estrogens;Event;Fertilization in Vitro;Follicle Stimulating Hormone;Follicle Stimulating Hormone Receptor;gain of function;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Genomics;glycosylation;Goals;Gonadotropins;granulosa cell;Growth;Health;hormonal signals;Human;improved;In Vitro;in vitro Model;in vivo;Individual;Infertility;Irregular Menstruation;Knowledge;Longevity;loss of function;Mediating;Medical;Menopause;Modeling;Modification;mouse model;mullerian-inhibiting hormone;Mus;Natural Fertility;novel;Occupations;Older Population;older women;oocyte maturation;Ovarian;Ovarian aging;ovarian failure;Ovarian Follicle;Pathology;Pathway interactions;Pattern;Perimenopause;Phosphorylation;Physiological;Pituitary Gland;Play;pro-aging;Process;programs;Proliferating;protein activation;Repression;reproductive;Reproductive Health;Research Personnel;response;Role;Sampling;senescence;Serum;Signal Pathway;Signal Transduction;small hairpin RNA;Social Change;Steroid biosynthesis;Testing;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Translating;Withdrawal;Woman

PROJECT_TITLE: Project 2: Role of Glycosylation in FSH Signaling in FSH Target Cells