NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Prevention;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE This project is relevant to public health because it will generate knowledge about the effects of state financing policies on the implementation of the federal “988” law and the National Suicide Prevention Lifeline. The project will produce information about how the implementation of policies that finance the Lifeline can by optimized to prevent suicide death—a top priority of NIMH.

PI_NAMEs: PURTLE, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Adopted;Adoption;Age;American;Area;Authorization documentation;Cellular Phone;Cessation of life;Characteristics;Code;contextual factors;Data;Databases;Digit structure;Distal;Ecology;Effectiveness;effectiveness outcome;Emotional;Ethnic Origin;evidence base;Evidence based intervention;Exploration, Preparation, Implementation, and Sustainment;falls;federal policy;Feeling hopeless;Fees;Foundations;Funding;Future;Health;Heterogeneity;Hotlines;implementation determinants;implementation fidelity;implementation outcomes;implementation science;implementation strategy;improved;innovation;instrument;Interview;Knowledge;Laws;Leadership;Legal;Maps;Measures;Medicaid;Mental Health;National Institute of Mental Health;Outcome;Perception;Policies;Policy Analysis;prevention service;Process;psychological distress;Psychometrics;Public Health;Race;reducing suicide;Reporting;response;Route;Self-Injurious Behavior;Services;Statutes and Laws;Strategic Planning;Structure;success;suicidal;suicidal morbidity;Suicide;Suicide prevention;suicide rate;Surveys;System;telephone based;Time;Training;trend;United States;United States Agency for Healthcare Research and Quality;Violence

PROJECT_TITLE: Implementation of the Federal 988 Suicide and Mental Health Crisis Hotline Policy: Determinants and Effects of State Policy Implementation Financing Strategies

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: CHARLESTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE Currently, no established pharmacological treatments for the prevention and management of noise-induced hearing loss (NIHL) exist, owing largely to the lack of a comprehensive understanding of the precise molecular mechanisms and signaling pathways mediating sensory hair cell injury. This resubmission of a competing renewal application employs preclinical mouse models subjected to a variety of severities of noise exposure for investigation of both molecular mechanisms and prevention of NIHL by applying cutting-edge analytical technology. The outcome of this proposal will guide the design of novel clinical interventions for the prevention of NIHL, benefiting the quality of life of individuals and reducing healthcare costs.

PI_NAMEs: SHA, SU-HUA  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acute;adeno-associated viral vector;Adopted;Adult;Affect;Animal Model;Antioxidants;attenuation;Auditory;Autophagocytosis;Biochemical;Calcium;Calmodulin;CaM kinase I activator;Cell Death;cell injury;Cell Nucleus;Cell Survival;Cessation of life;Clinical;Clinical Trials;Cochlea;cytokine;Cytokine Gene;Data;design;dosage;Epigenetic Process;Event;Exposure to;Failure;FK506;Fluorescent in Situ Hybridization;G9a histone methyltransferase;Gene Expression;Gene Expression Profile;Gene set enrichment analysis;Genetic Transcription;Goals;Hair Cells;Health Care Costs;hearing impairment;hearing loss treatment;Immunohistochemistry;in vivo;Individual;inhibitor;inner ear diseases;innovation;insight;Intervention;Investigation;Measurement;Mediating;Mediator;Metabolic;Metabolic Pathway;Modeling;Molecular;mouse model;Mus;Noise;noise exposure;Noise-Induced Hearing Loss;novel;novel therapeutic intervention;nuclear factors of activated T-cells;Nuclear Translocation;otoprotectant;Outcome;Outer Hair Cells;Pathologic;Pathology;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phosphotransferases;pre-clinical;Preparation;Presbycusis;prevent;Prevention;preventive intervention;Protein Isoforms;Quality of life;Reactive Oxygen Species;Recovery;Research;response;Role;Sensory Hair;Severities;Signal Pathway;Signal Transduction;single cell genomics;single-cell RNA sequencing;small hairpin RNA;Small Interfering RNA;STK11 gene;Surface;Synapses;System;Technology;Temporary Threshold Shift;Testing;Therapeutic;Therapeutic Intervention;tool;transcription factor NF-AT c3;Transfection;Virus

PROJECT_TITLE: Molecular mechanism in noise-induced hearing loss

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Nutrition;Obesity;Prevention;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

PHR: This research seeks to move the needle forward on effective digital weight control treatment to reduce rural health disparities by simultaneously investigating 3 online intervention components that are personnel- intensive to determine which combination of these “high touch” treatment components produces optimal weight losses among adults with overweight and obesity who live in rural regions of the United States.

PI_NAMEs: KRUKOWSKI, REBECCA A.;WEST, DELIA SMITH (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Accountability;Address;Adult;Aftercare;Age;Area;Behavior Therapy;Behavioral;Body Weight decreased;Chronic Disease;Clinical;Communities;comorbidity;Congresses;cost;County;Diabetes Mellitus;diabetes prevention program;Dietary intake;digital;digital delivery;digital intervention;digital treatment;Effectiveness;Electronic Mail;Elements;Enrollment;ethnic minority;Ethnic Origin;evidence base;experience;experimental study;Feedback;Gender;Geography;health disparity;Human;Human Resources;implementation cost;Individual;Informal Social Control;Internet;Intervention;Life Style;lifestyle intervention;male;Mediator;Minority;Monitor;Motivation;multiphase optimization strategy;Needles;Obesity;obesity treatment;online intervention;Outcome;Overweight;Participant;Persons;Physical activity;Pilot Projects;Policies;Population;prevent;Problem Solving;Process;Professional counselor;programs;Public Health;Race;racial minority;Randomized;recruit;remote delivery;Research;Resources;Risk;Rural;rural area;Rural Community;rural counties;rural dwellers;rural health disparities;Rural Population;rural setting;sex;Site;Social support;Subgroup;telephone coaching;Testing;Time;Touch sensation;treatment optimization;treatment program;underserved community;United States;United States Centers for Medicare and Medicaid Services;video session;Weight;Weight Gain;weight loss intervention;Weight maintenance regimen

PROJECT_TITLE: Addressing Rural Health Disparities by Optimizing "High Touch" Intervention Components in Digital Obesity Treatment


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Menopause;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHIATRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE The cumulative rate of repeated trauma exposure is disproportionately greater in Black communities of urban, low socioeconomic status. While studies suggest that hormonal changes may influence mood symptoms in women, perimenopausal women have received minimal focus in trauma-related mental health research. The current study aims to address this gap in knowledge by investigating neuroendocrine mechanisms underlying longitudinal changes in trauma-related hyperarousal and responsivity to threat during the perimenopause.

PI_NAMEs: MICHOPOULOS, VASILIKI  (contact);STEVENS, JENNIFER STRAFFORD

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: accelerated epigenetic aging;Acute;Address;Age;Amygdaloid structure;anxiety symptoms;Biological Factors;Black race;black women;Blood;Brain region;Clinical;conditioned fear;Data;depressive symptoms;Development;Epigenetic Process;Estradiol;experience;Extinction;Face;Female;Fright;Functional Magnetic Resonance Imaging;Goals;Gonadotropins;Hormonal;Hormonal Change;Hospitals;Hypersensitivity;Interview;Knowledge;life span;Link;low socioeconomic status;Mental Health;mood symptom;mortality;mortality risk;Neurobiology;Neuroendocrinology;neuroimaging;Neurosecretory Systems;Outcome;Ovarian Steroid Hormone;Perimenopause;Population;Positioning Attribute;Post-Traumatic Stress Disorders;Prefrontal Cortex;Premenopause;Prevalence;Process;psychologic;Psychopathology;Psychophysiology;recruit;reproductive;Research;response;Risk;sex;socioeconomics;steroid hormone;Stimulus;Structure;symptom treatment;Symptoms;Testing;Time;Trauma;trauma exposure;Urban Community;Variant;Woman;Work

PROJECT_TITLE: Neuroendocrine Mechanisms Underlying Perimenopausal Risk for Trauma-Related Hyperarousal in Black Women


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Disease;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Biliary fibrosis is a process of peri-portal scarring within the liver that is caused by diseased bile ducts and often progresses to end stage liver disease. Thus, it is necessary to understand the mechanisms regulating biliary fibrosis and to identify pathways that can be targeted therapeutically. This proposal will focus on understanding how lncRNAs affect epigenetic regulation in bile duct cells (cholangiocytes) and how this leads to the release of molecules that subsequently activate hepatic stellate cells and perpetuate biliary fibrosis.

PI_NAMEs: HUEBERT, ROBERT CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Affect;Antisense Oligonucleotides;Area;bile duct;Bile Duct Diseases;Biliary;Biliary Atresia;Biliary cirrhosis;Binding;Biological Assay;Biology;ChIP-seq;cholangiocyte;Cholestasis;Chromatin;chromatin isolation by RNA purification sequencing;Chronic;Cicatrix;congenital hepatic fibrosis;connective tissue growth factor;Data;Deposition;derepression;Disease;Ductal Epithelial Cell;end stage disease;end stage liver disease;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;epigenetic silencing;epigenome;Epithelium;Event;Exclusion;Extracellular Matrix;EZH2 gene;fibrogenesis;Fibronectins;Fibrosis;Foundations;gene network;Gene Silencing;Genetic Transcription;Hepatic Stellate Cell;histone modification;Histones;Homologous Gene;Human;Hybrids;Immunoprecipitation;in vivo;Injury;Intervention;Knock-out;Knockout Mice;Lead;Liver;Liver diseases;liver transplantation;locked nucleic acid;Lysine;Mediating;Mediator;Mesenchymal;Microfluidics;Modernization;Molecular;Molecular Target;mouse model;Mus;novel;novel therapeutic intervention;Organoids;paracrine;Paracrine Communication;Pathologic;Pathway interactions;Patients;Pharmacology;prevent;Primary biliary cirrhosis;primary sclerosing cholangitis;Process;Production;recruit;response;RNA;Role;Signal Induction;Signal Transduction;Signaling Molecule;System;targeted treatment;Technology;Testing;TGFB2 gene;Therapeutic;therapeutic RNA;transcriptome sequencing;Transferase;Transforming Growth Factor beta;Transforming Growth Factor Beta 2;Untranslated RNA;Up-Regulation

PROJECT_TITLE: Molecular Mechanisms of Cholestatic Fibrogenesis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative The immune system is important for fighting off infection with bacteria, viruses and fungi and can also eliminate tumors in some individuals with cancer. One type of immune cell that plays a particularly important role in eliminating viruses, some bacteria and tumor cells is the so-called CD8 T cell. The studies described in this proposal will lead to a better understanding of how CD8 T cells respond (or not) to cancer and as such may lead to better therapies for treating cancer by identifying novels ways to enhance immune responses to cancer.

PI_NAMEs: KANE, LAWRENCE P. (contact)

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: Affinity;antigen-specific T cells;Antigens;Antitumor Response;Bacteria;Binding;Biological Assay;C57BL/6 Mouse;CAR T cell therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Immunity;chimeric antigen receptor T cells;Clinical Research;Colon Carcinoma;Core Facility;CTLA4 gene;cytotoxic CD8 T cells;cytotoxicity;Discrimination;engineered T cells;Epitopes;Exclusion;fighting;fungus;Future;Genetic;Hematologic Neoplasms;Hybridomas;Immune;immune checkpoint blockade;Immune response;Immune system;In Vitro;Individual;Infection;Infiltration;Infusion procedures;Knowledge;Ligands;Lymphocytic choriomeningitis virus;Malignant Neoplasms;MC38;Mediating;Methylcholanthrene;Modality;Modeling;Monoclonal Antibodies;mouse model;Mus;Mutate;neoantigens;Neoplasm Transplantation;neoplastic cell;novel;Ovum;Patients;Peptides;Physiologic pulse;Play;Population;preclinical study;programmed cell death protein 1;Proliferating;recruit;Reporting;Research Personnel;response;Ribosomal Proteins;Role;Sensitivity and Specificity;success;T cell response;T-Cell Activation;T-Cell Development;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Epitopes;targeted treatment;Testing;Therapeutic;Transgenes;Transgenic Mice;Transplantation;tumor;Tumor Antigens;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Vaccination;Virus;Virus Diseases;weapons

PROJECT_TITLE: Novel TCR transgenic mice to study tumor neoantigen-specific T cell responses

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (O1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Muscular Dystrophy;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Narrative  The endoplasmic reticulum (ER) stress response appears is a universal feature of all cardiomyopathies as well as healing after cardiac injury or disease initiation. Here we have identified a novel function for thrombospondin3 (Thbs3) and Thbs4 as intracellular regulators of the ER pathway shuttling of membrane attachment complexes, such as the integrins and dystrophin-glycoprotein complex (DGC), which impacts the stability of the plasma membrane in heart and skeletal muscle. Understanding the mechanisms whereby the Thbs proteins regulate cellular attachment complexes in the plasma membrane has profound medical relevance as many forms of heart disease are associated with altered membrane strength and cellular connection to the extracellular matrix.

PI_NAMEs: MOLKENTIN, JEFFERY D (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Acute;Address;Adhesions;Amino Acids;Award;Biological;biological adaptation to stress;Biological Process;Calcium Binding;Cardiac;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Cell membrane;Cell-Matrix Junction;Cells;Chronic Disease;Collaborations;Complex;Data;Dilated Cardiomyopathy;Disease;Disease susceptibility;Drosophila genus;Dystrophin;Effectiveness;Endoplasmic Reticulum;endoplasmic reticulum stress;experimental study;Extracellular Matrix;Family;Family member;Funding;Gene Family;Gene Frequency;gene therapy;Genes;Glycoproteins;Goals;healing;Heart;Heart Diseases;Heart failure;Heart Injuries;Human;in vivo;Injury;Integrin Binding;Integrins;Knock-in Mouse;Knockout Mice;Mechanics;Mediating;Medical;Membrane;Modeling;Molecular;Molecular Chaperones;mouse model;Mus;Muscle Cells;Muscular Dystrophies;Muscular dystrophy cardiomyopathy;Mutation;Myocardium;Netherlands;novel;novel strategies;overexpression;Pathway interactions;Patients;Play;Positioning Attribute;Predisposition;proband;protein complex;protein function;Protein Glycosylation;Protein Secretion;Proteins;Recycling;Regulation;RGD (sequence);Role;Rupture;Sarcolemma;Series;Signal Transduction;Site;Skeletal Muscle;Stimulus;Stress;Therapeutic;therapeutic gene;Thrombospondin 1;thrombospondin 3;thrombospondin 4;Thrombospondins;Transgenic Mice;Translating;Variant;Work

PROJECT_TITLE: Thrombospondin 4 regulates adaptive ER stress responseRenewal - Resubmission - 1

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Microbiome;Neurosciences;Prevention;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed translational research is relevant to public health because it will launch our understanding of if and how fecal microbial transplant treatment strategies may ameliorate the negative consequences of chemotherapy. Thus, the proposed research is relevant to part of NCI/NIH’s mission that pertains to reducing cancer-related comorbidities, which in turn, improves health and quality of life.

PI_NAMEs: PYTER, LEAH M (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Adherence;Affect;Anorexia;anxiety-like behavior;Attention;Attenuated;autism spectrum disorder;Autologous;Behavior;behavior influence;Behavior Therapy;Behavioral;Behavioral Symptoms;Brain;brain research;Breast Cancer Patient;Cancer Patient;cancer therapy;Central Nervous System Diseases;chemokine;chemotherapy;Clinical;Clinical Research;Clinical Trials;Clostridium difficile;Cognitive;Cognitive deficits;Communication;comorbidity;Data;Diarrhea;Dose;dysbiosis;efficacy evaluation;Excision;Fatigue;Feasibility Studies;fecal transplantation;Foundations;Functional disorder;Future;gastrointestinal;Goals;gut dysbiosis;gut microbiome;gut microbiota;Health;Immunotherapy;improved;ineffective therapies;Infection;Inflammatory;inflammatory marker;innovation;Intervention;Knowledge;Life;loved ones;Malignant Neoplasms;Mammary Neoplasms;Methods;microbial;microbial based therapy;Microglia;Mission;Modeling;Moods;mortality;Mus;Neurobiology;novel;novel therapeutics;Patients;Pharmaceutical Preparations;Population;pre-clinical;prevent;Preventive treatment;Psyche structure;Public Health;Publishing;Quality of life;Radiation;Research;Research Project Grants;response;Rodent;Role;Saline;Scientist;side effect;Signal Transduction;standard of care;Stem cell transplant;Supportive care;systemic inflammatory response;Testing;Therapeutic;Time;Translating;Translational Research;Transplant Recipients;transplantation therapy;treatment strategy;tumor;United States National Institutes of Health;Work

PROJECT_TITLE: Fecal microbial transplantation for chemotherapy behavioral side effects

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: PHILADELPHIA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE Articular cartilage disorders, including osteoarthritis, are a major cause of suffering and healthcare costs worldwide. The overall objective of this study is to delineate mechanisms by which collagen III regulates chondrocyte behaviors and the production of a cartilage extracellular matrix (ECM) that is capable of efficient transmission of loads across articular surfaces and resistant to degradation. Our proposed experiments will investigate how collagen III regulates chondrocyte behaviors, including their production and maintenance of a high-quality ECM and how this knowledge can be harnessed to improve therapeutic strategies to prevent cartilage degeneration and resurface damaged joints.

PI_NAMEs: HAN, LIN  (contact);VOLK, SUSAN W

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 3-Dimensional;Acceleration;Age Months;aggrecan;Aging;Architecture;articular cartilage;Atomic Force Microscopy;Attenuated;Behavior;Biocompatible Materials;Biological Assay;Biomechanics;Calcium Signaling;Cartilage;cartilage degradation;Cartilage Diseases;Cartilage Matrix;Cells;Chondrocytes;Clinical;clinical application;Collagen;Collagen Fibril;Collagen Type III;crosslink;Cytoskeleton;Data;Degenerative polyarthritis;density;Diameter;Disease;Dose;experimental study;Extracellular Matrix;Extracellular Matrix Degradation;Fibrillar Collagen;Gene Expression;Gene Expression Profiling;Growth;Harvest;Health;Health Care Costs;Heterogeneity;Human;Hydrogels;Image;Immunofluorescence Immunologic;Impairment;improved;In Situ;In Vitro;in vivo;Inflammatory;Injury;innovation;Integrins;Interleukin-1 beta;Intervention;joint injury;Joints;Knockout Mice;Knowledge;laser capture microdissection;Maintenance;Mechanics;mechanotransduction;Medial meniscus structure;Mediating;Mediator;meter;Modeling;Modulus;Molecular;mouse model;multidisciplinary;Mus;nano;nanomechanics;novel;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;Pattern;Phenotype;Play;postnatal;Predisposition;preservation;prevent;Production;regenerative approach;Regulation;Resistance;response;Role;Signal Transduction;Stimulus;Structure;Surface;Techniques;Testing;Therapeutic;therapeutic target;Thick;Tissue Engineering;Tissues;transcriptome sequencing;transmission process;Traumatic Arthropathy;young adult

PROJECT_TITLE: Roles of Type III Collagen in the Matrix Assembly and Mechanobiology of Cartilage

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Dietary Supplements;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative Existing bone regenerative biomaterials are featured with inabilities to mimic the native tissue composition, and slow bone regeneration among others. In this proposal, we will reach a fundamental understanding of unprecedented synergistic optoelectro-metabonegenic regulation mechanism in bone repair, will design biomimetic optoelectroactive citrate biocomposites to achieve promoted bone repair. Our study will hold the potential to transform the fields of issue engineering and regeneration, and bioelectronics among others.

PI_NAMEs: YU, CUNJIANG  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Address;Anatomy;Animal Experiments;Architecture;Biocompatible Materials;bioelectronics;Biomimetics;bone;Bone Development;Bone Diseases;bone healing;Bone Matrix;Bone Regeneration;bone repair;Calcium;Calcium Channel;calmodulin-dependent protein kinase II;Cells;Cellular Metabolic Process;Cephalic;Chemicals;Citrates;Clinical Treatment;Collaborations;Combined Modality Therapy;Complex;Defect;design;Development;Developmental Process;disability;Effectiveness;Electric Stimulation;Energy consumption;Energy Metabolism;Energy Supply;Engineering;Exhibits;Family;FRAP1 gene;Goals;In Situ;in vivo;Inflammatory Response;Light;Lighting;Mechanics;Mediating;member;Mesenchymal Differentiation;Mesenchymal Stem Cells;mineralization;Minerals;Mitochondria;Modeling;Natural regeneration;next generation;novel;novel strategies;Orthopedics;Osteoblasts;Osteogenesis;osteogenic;Oxidative Phosphorylation;pain reduction;Pathway interactions;Performance;Physiological;Play;Process;Protein Biosynthesis;Proteins;Rattus;regenerative;Regulation;Research Proposals;Role;scaffold;Signal Pathway;Skeletal system;solute;stem cell differentiation;stem cells;Stimulus;Time;Tissues;Translating;voltage;wireless

PROJECT_TITLE: Optoelectroactive citrate biocomposites for bone regeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Obesity

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Modified Public Health Relevance Section Type 2 diabetes and NAFLD are emerging as two of the most critical global health challenges of the 21st century. This grant will provide important new insights into the role of altered hepatic mitochondrial function in  the pathogenesis in these diseases and novel hepatic mitochondrial-targeted therapies.

PI_NAMEs: PETERSEN, KITT F;SHULMAN, GERALD I (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acute;Address;Adolescent;Affect;Agonist;awake;Body Weight decreased;Child;Chronic;Cirrhosis;Clinical Trials;Data;Development;Diabetes Mellitus;Disease;Elderly;Fatty acid glycerol esters;Fatty Liver;General Population;global health;Glucagon;Glucagon Receptor;glucagon-like peptide 1;Gluconeogenesis;glucose metabolism;Grant;Hepatic;hepatic gluconeogenesis;Human;Individual;Infusion procedures;insight;Insulin Resistance;insulin sensitivity;ketogenesis;lipid metabolism;Lipids;Liver;Liver diseases;liver metabolism;Liver Mitochondria;Measures;Methods;Mitochondria;mitochondrial metabolism;Modeling;Muscle Mitochondria;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;nonhuman primate;novel;obesity treatment;oxidation;Participant;Pathogenesis;Patients;Phase;Physiological;public health relevance;Pyruvate Carboxylase;Resolution;Rodent;Rodent Model;Role;Science;sex;Steatohepatitis;targeted treatment;Testing;Tracer;Triglycerides;Weight

PROJECT_TITLE: Targeting hepatic mitochondrial oxidation to treat NAFLD, NASH and type 2 diabetes

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Certain higher visual motion areas have been found to mature surprisingly early, as early as the primary visual cortex. Developmental models will therefore need to include their action, in addition to that of the primary visual cortex, to appropriately capture the forces shaping early visual development. To fill this gap and improve our understanding of the mechanisms responsible for normal development, this project focuses on the interaction between primary visual cortex and higher motion area PSS during early visual development in the ferret.

PI_NAMEs: NIELSEN, KRISTINA J. (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Adult;Age;age related changes;animal old age;Area;area MT;area striata;Automobile Driving;Complex;Data;Development;Endowment;Excision;experimental study;Exposure to;extracellular;Eye;Feedback;Ferrets;flexibility;Gatekeeping;Goals;Homologous Gene;improved;Injections;Lateral Geniculate Body;Measures;model development;Modeling;Motion;Nature;neural;optogenetics;Pathway interactions;Phase;Primates;Process;Residual state;response;Role;Shapes;Signal Transduction;Standard Model;Sum;Testing;Thalamic structure;Time;Tracer;Training;Vision;vision development;Visual;Visual Motion;visual processing;visual stimulus

PROJECT_TITLE: Early development of higher visual motion area PSS mechanisms and consequences

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Osteoporosis;Prevention

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE There is a decrease in bone mineral density (BMD) as we age, increasing our risk for fractures and developing osteoporosis, a significant public health problem. Currently, most patients with low BMD are not screened using dual energy x-ray absorptiometry (DXA), therefore there is a need for opportunistic screening for low BMD. This proposal proposes using deep learning analysis of radiographs to identify patients at risk for low BMD who would benefit from DXA.

PI_NAMEs: SEBRO, RONNIE  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Age;Alcohol consumption;Architecture;Artificial Intelligence;artificial intelligence model;attenuation;bone;Bone Density;bone quality;Categories;Clinical;clinical care;clinical practice;Data;Death Rate;deep learning;deep learning model;Development;Devices;Diagnosis;Disease;Dual-Energy X-Ray Absorptiometry;Evaluation;Femur;Fracture;fracture risk;Future;Goals;Health Care Costs;Healthcare;Height;Hip Fractures;Hip region structure;Image;imaging biomarker;Imaging Techniques;Implant;improved;Income;Individual;innovation;Life;Locomotion;Maintenance;Measurement;Measures;metallicity;Modeling;Morbidity - disease rate;mortality;Neck;novel;older patient;Orthopedics;Osteopenia;Osteoporosis;osteoporosis with pathological fracture;Osteoporotic;Pain;Parents;Patient Care;patient screening;Patients;Postmenopause;predictive marker;predictive tools;prevent;Probability;Process;Public Health;Publishing;radiomics;Recording of previous events;Replacement Arthroplasty;Reporting;Reproducibility;Rheumatoid Arthritis;Risk;Risk Adjustment;Risk Marker;risk prediction;sample fixation;Scanning;Science;screening;sex;Site;Smoking Status;standard measure;Steroids;substantia spongiosa;Techniques;Testing;tool;Trabecular Bone Score;United States;Vertebral column;Weight;Woman;Work;World Health Organization;X-Ray Computed Tomography

PROJECT_TITLE: Deep learning for opportunistic screening for osteoporosis and osteopenia from radiographs

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-G (O1)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative Malfunction of the midbrain dopamine system is associated with a variety of pathological conditions including depression, anhedonia, apathy, schizophrenia, addiction, eating disorders and Parkinson’s disease. Deeper understanding of mechanisms that regulate dopamine activity will provide foundations for understanding the causes of various psychiatric disorders and for identifying potential targets for treatment.

PI_NAMEs: UCHIDA, NAOSHIGE  (contact);WATABE-UCHIDA, MITSUKO

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Anatomy;Anhedonia;Aversive Stimulus;Behavior;Brain;Brain region;cell type;Corpus striatum structure;Cues;Data;Development;Disease;Dopamine;dopamine system;dopaminergic neuron;Dorsal;Eating Disorders;Electrophysiology (science);Event;Exhibits;expectation;Fiber;Foundations;gamma-Aminobutyric Acid;Generations;Genetic;Glutamates;Label;Learning;Link;Maps;Mental Depression;Mental disorders;Methods;Midbrain structure;Modeling;Molecular;Mood Disorders;Motivation;Movement;neural circuit;neuromechanism;Neurons;Neurotransmitters;novel;optogenetics;Parkinson Disease;Pathologic;Pattern;Photometry;Play;postsynaptic;predictive modeling;presynaptic neurons;Process;Rabies virus;Regulation;Research;response;Rewards;Role;Schizophrenia;sensor;Sensory;Shapes;Signal Transduction;Stimulus;Testing;Time;tool;transmission process;Ventral Striatum;Ventral Tegmental Area;Work

PROJECT_TITLE: Dissecting the neural circuit mechanisms that generate dopamine neuron activity

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: TUCSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Adolescence is marked by an increase in vulnerability to mental disorders due to a profound structural and functional reorganization of the brain. We propose a series of studies that will generate new insights into the developmental changes that support the maturation of the amygdalo-orbitofrontal reward circuits. The application is based on the hypothesis that the maturation of these reward circuits underlies both social and non-social behaviors that are re-tuned and expanded during adolescence.

PI_NAMEs: CHANG, STEVE W. C.;GOTHARD, KATALIN M (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent Behavior;Adult;Affective;Amygdaloid structure;Anxiety;Area;Behavior;Behavior monitoring;Behavioral;Benefits and Risks;Brain;Cells;Cognitive;COVID-19 pandemic;Data;Decision Making;design;Development;discounting;Disparity;Economics;Education;emotion regulation;Emotional;Emotional Bonds;Endocrine;Endocrinology;Female;Foundations;Frequencies;gaze;Glean;Goals;gray matter;Hormonal;Human;Impulsivity;Incidence;Individual;innovation;insight;International;joint attention;Joints;Knowledge;Longitudinal Studies;Macaca;male;Measures;Mental Depression;Mental disorders;Mental Health;Modeling;Monitor;Monkeys;Motivation;MRI Scans;multidisciplinary;myelination;neural;neural circuit;neuroimaging;Neurons;neurophysiology;nonhuman primate;nutrition;Outcome;Partner in relationship;peer;Peer Group;Performance;pleasure;Population;Prefrontal Cortex;Process;Property;Psychological reinforcement;Puberty;Race;response;Rest;reward processing;Rewards;Risk;Risk Estimate;Risk Taking;Saccades;Sampling;Serial Magnetic Resonance Imaging;Series;Severities;sex;skill acquisition;social;Social Behavior;Social Environment;social group;Social Interaction;Social isolation;social skills;Social status;statistics;Stress;Suicide;Testing;Time;United States National Institutes of Health;white matter;Youth

PROJECT_TITLE: Maturation of Social and Non-Social Reward Processing in the Adolescent Amygdala and Orbitofrontal Cortex


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Emergency Care;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: CLEVELAND

ORG_DEPT: NEUROLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE The Case Western Reserve University Stroke Net Regional Coordinating Center proposes to continue as a regional coordinating site. We have proven our ability to conduct stroke trials within the network and to interact with other sites, the National Coordinating Center, and the Data Monitoring Center. Additionally, we have expanded our coordinating center and are well positioned to accelerate our participation in Stroke Net over the next 5 years.

PI_NAMEs: SUNDARARAJAN, SOPHIA  (contact);UCHINO, KEN

PROGRAM_OFFICER_NAME: MCCARTHY, SEAN PATRICK

PROJECT_TERMS: Academic Medical Centers;Acceleration;Accident and Emergency department;Acute;acute care;Adult;Agreement;Air;Blood Vessels;career development;Caring;Child;Childhood;Clinic;Clinical Trials;Clinical Trials Design;Clinical Trials Unit;Collaborations;Community Hospitals;County Hospitals;Critical Care;Data;Education;Emergency Medicine;Enrollment;Ensure;Ethnic Origin;functional electrical stimulation;Funding;Health;Healthcare;Hospitals;Human Resources;Image;Individual;Intervention;Leadership;Medical center;member;Mentors;Mentorship;Michigan;Monitor;Neurologist;Neurosurgeon;novel therapeutics;Nurse Practitioners;Ohio;organizational structure;Participant;participant enrollment;patient population;Pennsylvania;Physical Medicine;Physical Rehabilitation;Physicians;Population;Positioning Attribute;Prevention;Race;Recovery;Rehabilitation therapy;Research Personnel;Resources;Role;Route;Running;Rural;Scientist;screening;sex;Site;Specialist;Stroke;stroke clinical trials;stroke patient;Stroke prevention;stroke trials;Structure;study population;success;Surgeon;System;Training;Transportation;trial enrollment;United States Department of Veterans Affairs;Universities;University Hospitals;West Virginia;Work;working group

PROJECT_TITLE: Case Western Reserve University StrokeNet University Regional Coordinating Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (17)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE The major goal of this research program is to develop improved ways of conducting human disease association studies by comprehensively identifying new variants and genes which contribute to complex human diseases and traits. Although sequencing the entire genome is now possible in large-scale disease focused gene mapping studies, available methods for analyzing sequence data are fundamentally unable to identify all genetic variation, particularly in large multi-ethnic studies. We will build a new system based on a diverse set of reference genomes to comprehensively identify complex genomic variants in a large multi-ancestry study and assess their contribution to human diseases and complex traits.

PI_NAMEs: HALL, IRA M (contact);STITZIEL, NATHAN OLIVER

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Accounting;Admixture;All of Us Research Program;analysis pipeline;Awareness;Benchmarking;biobank;Biology;cardiometabolic risk;cardiometabolism;Chromosome Mapping;cohort;Communities;Complex;Coronary Arteriosclerosis;Coronary heart disease;Data;data resource;Data Set;deep learning;design;Diploidy;Disease;disorder risk;experience;Funding;gene expression variation;Generations;Genes;Genetic;genetic association;Genetic Diseases;genetic variant;Genetic Variation;Genome;genome analysis;Genome Mappings;genome sequencing;Genomics;Genotype;Genotype-Tissue Expression Project;Goals;Graph;Haplotypes;Heritability;Human;human disease;Human Genome;human pangenome;improved;Individual;insertion/deletion mutation;insight;interest;Length;Literature;Maps;Measures;Medical;Methods;Minisatellite Repeats;Modeling;multi-ethnic;National Human Genome Research Institute;next generation;novel;novel strategies;pan-genome;Participant;Pattern;Performance;phenome;Phenotype;Population;Population Heterogeneity;Production;programs;reference genome;Research;Resources;Risk;Risk Factors;Role;Sample Size;Sampling;Single Nucleotide Polymorphism;System;Tandem Repeat Sequences;Testing;Time;tool;trait;Trees;Variant;variant detection;whole genome;Work

PROJECT_TITLE: A paradigm for comprehensive genetic association studies of complex disease using pangenomic methods and local ancestry inference

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Cardiovascular;Estrogen;Heart Disease;Prevention;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Aortic valve stenosis (AVS) is a prevalent disease with no current treatment options other than surgical valve replacement. Advanced age and being male are the top risk factors for developing AVS, but it is not well understood why these features lead to increased disease risk. In the proposed work, we aim to build systems that mimic numerous aspects of valvular aging and sex differences to try to better understand what causes the onset of this disease. The long-term impacts of this work could be improved prevention, diagnosis, and treatment of AVS.

PI_NAMEs: MASTERS, KRISTYN S (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Address;Age;age related;age related changes;age-related disease;aged;Aging;Animal Model;aortic valve;aortic valve disorder;Aortic Valve Stenosis;Behavior;Benchmarking;Biochemical;Biological;biophysical properties;Biophysics;Bioreactors;cardioprotection;cell age;Cell Aging;cell behavior;Cells;Characteristics;Chronology;Controlled Environment;design;Diagnosis;Disease;disease model;disorder risk;Elderly;Elements;Engineering;Environment;Estrogens;Etiology;Event;Exhibits;Experimental Models;experimental study;Extracellular Matrix;Failure;Female;genotypic sex;Gonadal Steroid Hormones;hemodynamics;Hormonal;Hormonal Change;Human;human disease;human old age (65+);improved;In Vitro;in vitro Model;in vivo Model;Influentials;interstitial cell;Intervention;Investigation;Lead;Liquid substance;male;Mechanics;Memory;men;Menopause;Methods;Modeling;normal aging;Normal tissue morphology;novel;novel strategies;Onset of illness;Pathogenesis;Pathologic;Pathology;Pharmaceutical Preparations;Phenotype;Physical environment;Play;Predisposition;Prevalence;Prevention;prospective;response;Risk;Risk Factors;Role;scaffold;sex;Sex Differences;sexual dimorphism;shear stress;Side;Signal Pathway;Stimulus;Stress;Structure;Surgical Valves;System;Testing;therapeutic development;three dimensional structure;Tissue Engineering;Tissues;Validation;valve replacement;Woman;Work

PROJECT_TITLE: Engineered models of age-related biochemical, biophysical, and hormonal changes to elucidate mechanisms of aortic valve disease onset

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Neurosciences

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE Up to 44 million U.S. adults have difficulty hearing in noisy situations despite having no measurable hearing loss, and there is currently no consensus on how to diagnose or treat these individuals. The proposed studies will investigate the contribution of an auditory reflex to listening in background noise for adults with and without self- reported listening difficulties. The knowledge gained from these studies will contribute to improved diagnosis and interventions for individuals with listening difficulties.

PI_NAMEs: MERTES, IAN B. (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;Adult;age group;Animals;Area;Auditory;Auditory Brainstem Responses;auditory reflex;Auditory Threshold;Behavioral;Brain;Brain Stem;case control;Classification;Cochlea;Cognitive;Consensus;Contralateral;design;Development;Diagnosis;Diagnostic tests;Disease;Ear;Electrophysiology (science);Exhibits;Expenditure;experience;Foundations;Goals;Health;Hearing;hearing impairment;Human;improved;Individual;innovation;Intervention;Knowledge;Labyrinth;Measurable;Measures;Medial;National Institute on Deafness and Other Communication Disorders;Nature;neural;Noise;normal hearing;otoacoustic emission;Participant;Patient Self-Report;Peripheral;Physiologic pulse;Physiological;Positioning Attribute;programs;Quality of life;Questionnaires;Reaction Time;recruit;Reflex action;Research;Resources;response;Restaurants;Role;Sensorineural Hearing Loss;sex;Signal Transduction;sound;Speech;speech in noise;Testing;Translating;verbal;Work

PROJECT_TITLE: Olivocochlear Efferent Function: Associations with Hearing in Noise and Listening Effort

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_NAME: CARI HEALTH, INC.

ORG_STATE: CA

PHR: CARI Health proposes to develop a system for electrochemical medication detection in blood to provide immediate assessments of methadone metabolic rates in patients. Using biomarkers for drug metabolism has been a long-time goal for opioid use disorder care providers to enable safer, more effective prescription dosing. CARI’s innovative point-of-care methadone precision dosing system will enable science-based personalized care for patients in medication for opioid use disorder (MOUD) treatment, which has the potential to quickly stabilize patients, improve retention rates, and reduce relapse and overdoses.

PI_NAMEs: SCHMIDLE, PATRIK  (contact)

PROGRAM_OFFICER_NAME: KOSTOV, YORDAN VALTCHOV

PROJECT_TERMS: Address;Adopted;Algorithms;Benefits and Risks;Biological Markers;Blood;Blood specimen;Bone Pain;care providers;Caring;Categories;Chills;Classification;Clinical;Clinical Research;Clinical Trials;Commercial grade;commercialization;Computer software;Conduct Clinical Trials;Data;data and analysis portal;data pipeline;data platform;design;Detection;Devices;Diarrhea;Dose;Dropout;drug metabolism;Drug Prescriptions;Drug usage;Electrodes;experience;Feasibility Studies;fentanyl use;Fever;Fingers;Fright;Genetic;Goals;Health;Human;human subject;Hypertension;improved;Individual;innovation;Institutional Review Boards;Interview;Laboratories;Maintenance;Measurement;Measures;medication for opioid use disorder;meetings;Metabolic;metabolic rate;Metabolism;metabolomics;Methadone;methadone treatment;Methods;mobile application;mortality;Myalgia;Nausea;novel;Opiate Addiction;opioid use;opioid use disorder;Overdose;Pathway interactions;patient retention;Patients;Perception;Performance;personalized care;Pharmaceutical Preparations;Phase;Physical Dependence;point of care;Point of Care Technology;Prevalence;Printing;Relapse;relapse patients;response;retention rate;Risk;Sampling;Science;sensor;Serum;side effect;Signal Transduction;Small Business Innovation Research Grant;Software Validation;Specific qualifier value;System;Tachycardia;Technology;Testing;Therapeutic;Time;validation studies;Variant;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Methadone Dosing System (MDS)

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Genetic studies of prostate cancer have been tremendously successful in identifying more than 150 genomic risk regions that harbor variants increasing risk. Unfortunately, the causal mechanisms through which disease risk is altered at these loci remains elusive. In this proposal we develop and apply new statistical and experimental methods to find causal variants and genes for prostate cancer. Our proposal centers on germline variation that alter disease risk through up/down regulation of key risk genes.

PI_NAMEs: FREEDMAN, MATTHEW L (contact);PASANIUC, BOGDAN

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: 3-Dimensional;Address;Affect;Automobile Driving;Big Data;Biological Assay;Cancer cell line;causal variant;Cell Line;cell type;Chromatin;Clinic;cohort;Collaborations;Computing Methodologies;Consumption;cost;Data;Data Set;disorder risk;Down-Regulation;Epigenetic Process;epigenetic variation;epigenome editing;epigenomics;Etiology;experience;Foundations;functional group;Funding;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic association;Genetic Diseases;Genetic study;Genetic Variation;Genome;genome editing;genome wide association study;genome-wide analysis;Genomics;Genotype-Tissue Expression Project;Germ Lines;Germ-Line Mutation;Goals;Histones;improved;Individual;Inherited;innovation;Joints;Linkage Disequilibrium;LNCaP;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Mediating;men;Methods;Modeling;Modification;Molecular Conformation;multiple data types;new therapeutic target;next generation;novel;overexpression;Pathogenesis;personalized medicine;Population;Prostate;prostate cancer model;prostate cancer risk;prostate carcinogenesis;Regulation;Regulatory Element;Resolution;Risk;risk variant;Site;Solid;Statistical Algorithm;success;Susceptibility Gene;targeted treatment;The Cancer Genome Atlas;three dimensional structure;Time;Tissues;trait;Transcript;transcriptome;transcriptomics;Translating;Validation;Variant;whole genome

PROJECT_TITLE: Elucidation of the genetic mechanisms driving prostate tumorigenesis through integrative computational and functional approaches

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: East Dundee

ORG_NAME: AMERICAN SOCIETY OF ANDROLOGY

PHR: As a result of the American Society of Andrology (ASA) Annual Meeting, scientists will learn new findings to further their own research in male reproduction. Healthcare providers will be able to translate advances in biology into improved prevention, diagnosis and management of male infertility and reproductive disorders. If funded, this grant would provide an additional five years of support for trainees to attend and benefit from the Annual Meeting.

PI_NAMEs: GERTON, GEORGE L. (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: American;Andrology;Area;Award;Basic Science;Big Data;Biochemistry;Biology;career;Categories;Cellular biology;Charge;Clinical;clinical practice;Collaborations;Data;Dedications;Diagnosis;Disabled Persons;Discipline of obstetrics;Disease Management;Educational workshop;Employment;Endocrinology;Environmental Health;Equilibrium;Event;Funding;Generations;Genetic;Goals;Government Agencies;Grant;Gynecology;Health;Health Personnel;Hearing;improved;innovation;Institution;interest;Laboratories;Laboratory Technicians;Learning;lectures;male;male health;Male Infertility;Medical;Medicine;medicine man;meetings;member;Minority;Molecular;Molecular Biology;multidisciplinary;next generation;Nurses;Oral;Participant;Patients;Physicians;posters;Prevention;Private Practice;profession allied to medicine;Professional Organizations;programs;Reproduction;Reproductive Biology;reproductive function;reproductive system disorder;Reproductive Technology;Research;Research Personnel;Resource Sharing;Rewards;Sampling;Science;Scientist;Societies;Students;symposium;Technology;training opportunity;Translating;Translations;Travel;undergraduate student;Universities;Update;Urology;veterinary science;Woman;Work

PROJECT_TITLE: American Society of Andrology Annual Meeting

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_DEPT: VETERINARY SCIENCES

PHR: PROJECT NARRATIVE Combination antiretroviral therapy (cART) represents an historic advance in modern medicine, but these drugs are not curative. However, progress toward an HIV-1 cure has been very slow. We contend that our best hope for achieving a sustained HIV-1 remission in the absence of cART is to force latent proviruses into a deeper and irreversible state of latency. The central hypothesis of this application is that exogenous expression of a naturally occurring HIV-1 antisense transcript (Ast) will lead to robust, durable, sequence-specific silencing of HIV-1.

PI_NAMEs: ROMERIO, FABIO  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: Adult;Affect;Anti-Retroviral Agents;antiretroviral therapy;Base Pairing;Binding;Biological;Caring;CD4 Positive T Lymphocytes;Cell model;Cells;Chromatin;Chronic;clinical practice;Complex;Data;design;Development;Disease remission;DNA Sequence;Drug toxicity;Economics;emerging virus;Engineering;Epigenetic Process;epigenetic silencing;EZH2 gene;Feedback;Gene Expression;Genes;Genetic Transcription;Goals;HDAC2 gene;HIV;HIV-1;Human Genome;humanized mouse;Immunologics;Impairment;improved;In Vitro;in vivo;Individual;Infection;Inflammation;Interruption;Life;life time cost;Logistics;Lymphoid Tissue;Methylation;Modeling;Modern Medicine;Modification;mouse model;new technology;novel;novel strategies;Patients;peripheral blood;Persons;Pharmaceutical Preparations;Polycomb;posttranscriptional;prevent;protein TDP-43;Proviruses;reconstitution;recruit;Reporting;Repressor Proteins;Retroelements;Ribose;RNA;RNA Binding;RNA Stability;RNA-Protein Interaction;Sequence Homology;Series;Shock;Testing;Therapeutic;Therapeutic Agents;Tissues;Toxic effect;Transcript;transcription factor;Treatment-related toxicity;Virus Diseases;Virus Replication;Work;YY1 Transcription Factor

PROJECT_TITLE: Sustained HIV Remission via Sequence-Specific Epigenetic Silencing of Latent Proviruses


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Services;Hypertension;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: UNIVERSIDAD PERUANA CAYETANO HEREDIA

PHR: PROJECT NARRATIVE Hypertension is the major contributor to the global burden of disease. Completion of the proposed cluster randomized trial will provide compelling, robust evidence on the effects of a multicomponent intervention aimed at reducing blood pressure levels in a high-risk, vulnerable population in Puno, Peru. These data are urgently needed to inform policies in low- and middle-income countries on the health gains that can be obtained by implementation strategies geared towards reducing reduce hypertension among vulnerable populations.

PI_NAMEs: CHECKLEY, WILLIAM ;DAVILA-ROMAN, VICTOR G.;GENG, ELVIN H.;HARTINGER, STELLA MARIA (contact)

PROGRAM_OFFICER_NAME: BRUNO, FERNANDO PEREIRA

PROJECT_TERMS: Acceleration;Address;Adoption;Adult;Affect;aged;Altitude;Andean;Awareness;barrier to care;Behavior Therapy;Behavioral;Blood Pressure;blood pressure reduction;burden of illness;Caring;Chronic Care;Clinical;Clinical Research;Clinical Trials;Cluster randomized trial;Collaborations;Communities;community based care;community based service;Community Health;Community Health Aides;Community Healthcare;community intervention;Consolidated Framework for Implementation Research;cost;cost effectiveness;cost-effectiveness evaluation;Country;Data;Detection;Diabetes Mellitus;Diagnosis;Diet;dietary;disability-adjusted life years;Educational workshop;Effectiveness;effectiveness evaluation;Enrollment;Ensure;Epidemic;Epidemiology;Event;experimental study;follow-up;Health;health care settings;Health Fairs;Health Resources;health service use;Health system;High Prevalence;high risk;human centered design;Hypertension;hypertension control;hypertension treatment;implementation evaluation;implementation fidelity;implementation outcomes;implementation science;implementation strategy;implementation/effectiveness;Indigenous;Individual;innovation;Intervention;Intervention Trial;Interview;Investments;Link;low and middle-income countries;Measures;Methods;Modeling;models and simulation;Monitor;Morbidity - disease rate;mortality;multi-component intervention;Non-Insulin-Dependent Diabetes Mellitus;Outcome;patient engagement;patient population;Patients;Persons;Peru;Peruvian;Pharmaceutical Preparations;Phase;Policies;Policy Maker;Population;Positioning Attribute;Poverty;pragmatic trial;primary outcome;Probability Samples;Process;Public Health;Qualitative Methods;Randomized;Research;response;Rural;Savings;scale up;secondary outcome;service delivery;Service delivery model;Services;Shapes;success;Surveys;System;Testing;Time;treatment as usual;trial design;Tuberculosis;usability;Vulnerable Populations

PROJECT_TITLE: Addressing HyperteNsion and Diabetes through Community-Engaged Systems in Puno Peru (ANDES study)


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Project Narrative Immunotherapy is a highly attractive treatment modality for brain cancer patients. Unfortunately, currently available immunotherapies are not effective in GBM because T cell infiltration and activation are inhibited by immune suppressive myeloid and glioma cells. Successful completion of this study will reveal how S100A4 expression in glioma and immune cells suppress T cell infiltration and activation and generate necessary preclinical data to evaluate whether S100A4 is a viable target as a novel immunotherapy to treat GBM.

PI_NAMEs: YUN, KYUSON  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;aggressive therapy;Anti-Inflammatory Agents;Astrocytes;Biological Response Modifiers;Bone Marrow;Brain Neoplasms;Calcium-Binding Proteins;cancer cell;Cancer Patient;cancer type;Cells;Cementation;chemokine;chemotherapy;cytokine;Data;Data Analyses;Disease;Disease Progression;effector T cell;Environment;extracellular;genetic signature;Glioblastoma;Glioma;Goals;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune Evasion;Immune system;Immune System Diseases;immunoregulation;Immunosuppression;immunosuppressive macrophages;Immunotherapy;immunotherapy trials;in vivo imaging;Inflammatory;insight;Interleukin-10;knock-down;Laboratories;Leukocytes;Literature;Macrophage;Malignant neoplasm of brain;Malignant Neoplasms;Manuscripts;Mediating;Mediator;Mesenchymal;Microglia;Modality;molecular phenotype;molecular subtypes;monocyte;mouse model;multi-photon;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasm Metastasis;novel;novel strategies;Operative Surgical Procedures;Patients;Penetration;Phenotype;polarized cell;pre-clinical;Preparation;programs;protein function;Radiation therapy;recruit;Recurrence;Regulation;Regulatory T-Lymphocyte;Reporting;Role;S100A4 gene;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Solid Neoplasm;stem cell self renewal;Stromal Cells;success;T cell infiltration;T-Lymphocyte;Testing;The Cancer Genome Atlas;Tissues;trafficking;tumor;tumor-immune system interactions;virtual;Visualization;Work

PROJECT_TITLE: S100A4 mediated immune suppression in GBM


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Childhood Obesity;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative This proposal is a clinical trial in children who are at increased risk of developing nonalcoholic fatty liver disease (NAFLD) because of a first-degree relative with liver disease or type 2 diabetes and because of Hispanic ethnicity. The trial will test if an intensive home-based diet intervention to lower dietary sugar will prevent fat in the liver and the onset of NAFLD.

PI_NAMEs: VOS, MIRIAM B. (contact);WELSH, JEAN A.

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: 9 year old;Address;adipokines;Adipose tissue;Adult;Affect;Age;Alanine;behavior change;Biochemical;Biological Markers;Body Composition;Cardiovascular Diseases;chemokine;Chemosensitization;Child;Child Psychology;Clinical;Clinical Trials;Complex;Consumption;Counseling;Development;Diabetes Mellitus;diabetes risk;Diet;Dietary intake;Dietary Intervention;Dietary Sugars;Disease;disorder prevention;Dyslipidemias;Ethnic Origin;Family;Fatty acid glycerol esters;fatty acid oxidation;Fatty Liver;Feces;First Degree Relative;follow-up;Food;Future;Genetic;Genetic Polymorphism;genetic testing;genetic variant;Guidelines;Health;health care disparity;health disparity;Health Promotion;Hepatic;high risk;high risk population;Hispanic;Home;Home visitation;Hour;Image;improved;Inflammation;innovation;Insulin Resistance;insulin sensitivity;Intervention;Intervention Studies;Intramuscular;Juice;lifetime risk;lipid biosynthesis;lipid metabolism;Lipids;Liver;Liver Cirrhosis;Liver diseases;liver inflammation;liver transplantation;Longitudinal Studies;Magnetic Resonance Imaging;Malignant neoplasm of liver;Metabolic dysfunction;Metabolic Pathway;metabolome;metabolomics;Methods;Minority;Mission;Monitor;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Nursing Research;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Nursing Research;Nutritional Study;Obesity;Obesity associated liver disease;Observational Study;Onset of illness;Overweight;Pancreas;Patient Recruitments;Pattern;pediatric non-alcoholic fatty liver disease;Pediatric Research;Phase;Physiological;Plasma;prepuberty;prevent;Prevention;Prevention strategy;Prevention trial;primary health center;primary outcome;Primary Prevention;programs;Puberty;Randomized;randomized trial;randomized, clinical trials;Recording of previous events;Reduce health disparities;Research;research facility;response;Risk;Role;secondary outcome;Site;subcutaneous;sugar;Testing;Time;Transferase;treatment as usual;trial comparing;United States;Urine;Visceral

PROJECT_TITLE: Prevention of Pediatric NAFLD in Hispanic Children

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: WINSTON-SALEM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Narrative Microtubule impairments are implicated in several stages of Alzheimer's disease (AD) progression; it is caused by overproduction of hyperphosphorylated tau and poor mechanisms to clear the accumulation. We propose to create an innovative, clinically relevant AD targeting strategy using novel small molecule-based probes to image microtubules with positron emission tomography (PET). Our approach could significantly improve imaging strategies to track AD, and the ability to more precisely treat patients with neurodegenerative diseases early on.

PI_NAMEs: SOLINGAPURAM SAI, KIRAN  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta accumulation;AD transgenic mice;Affinity;Aftercare;Age Months;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer’s disease biomarker;Amyloid beta-Protein;APP-PS1;Attention;Autoradiography;Axonal Transport;beta amyloid pathology;Binding;Biochemical;Biodistribution;Biological Assay;Biological Markers;Brain;Cessation of life;Clinical;clinical imaging;Clinical Treatment;Clinical Trials;clinically relevant;Cognitive;cohort;Cytoskeleton;Data;density;Dependence;diagnostic biomarker;Disease;Disease Progression;Early Diagnosis;extracellular;Future;Glioblastoma;Goals;human subject;hyperphosphorylated tau;Image;imaging agent;imaging biomarker;imaging properties;imaging study;Impaired cognition;Impairment;improved;In Vitro;in vivo;in vivo imaging;innovation;Laboratories;Magnetic Resonance Imaging;Malignant neoplasm of brain;Measures;Methods;microPET/CT;Microtubule stabilizing agent;Microtubules;Modality;mouse model;Mus;Nature;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroimaging;Neurons;neuropathology;novel;overexpression;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Patients;Pharmaceutical Preparations;Positron-Emission Tomography;precision medicine;Process;Production;Reducing Agents;Reporting;Research;Research Personnel;scaffold;Signal Transduction;small molecule;Stabilizing Agents;standard care;Stratification;Structural Protein;targeted treatment;tau aggregation;tau Proteins;tau-1;Tauopathies;Techniques;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Therapeutic Studies;Time;tool;Tracer;transgenic model of alzheimer disease;Transgenic Organisms;translational potential;Treatment Protocols;treatment strategy;Tubular formation;uptake;Wild Type Mouse;Work;X-Ray Computed Tomography

PROJECT_TITLE: Evaluating microtubule binding as a potential imaging biomarker for Alzheimer's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: KANSAS CITY

ORG_NAME: STOWERS INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: MO

PHR: Narrative Protein aggregation is most often linked to loss of memory, such as in Alzheimer’s disease; however, aggregation of family RNA-binding protein stabilizes memory. The current proposal seeks to better understand the atomic level structure of these functional aggregates from human brain, their function in memory, and synaptic translation in mice. Understanding the structure and function of memory-promoting protein aggregates would be important to understand how protein aggregates can disrupt memory and will help develop meaningful treatment.

PI_NAMEs: SI, KAUSIK  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Acute;Address;Adult;Alzheimer's Disease;Amyloid;Amyloid beta-42;Animals;Aplysia;Autopsy;Binding Proteins;Biochemical;Biological;Biological Assay;Brain;brain tissue;Cell Physiology;Cells;Clinical Trials;Complex;CPE-binding protein;Cre lox recombination system;Cryoelectron Microscopy;Cytoplasmic Structures;Cytoplasmic Tail;Development;Disease;Drosophila genus;effective therapy;Excision;experience;Failure;Family;Family member;Foundations;Future;Human;human subject;hydrophilicity;Hydrophobicity;Immune;improved;In Vitro;in vivo;insight;Invertebrates;Knowledge;Length;Light;Link;Lobe;long term memory;Mammals;Memory;memory consolidation;Memory impairment;Memory Loss;memory recall;Methods;Modeling;Molecular;mRNA Translation;Mus;Nervous System;Neurodegenerative Disorders;Neurons;non-Native;Pathologic;Polyribosomes;preclinical trial;prion-like;Process;Property;Prosencephalon;protein aggregation;Protein Family;Protein Isoforms;Proteins;Proteome;proteostasis loss;RANK protein;Resistance;Resolution;RNA Binding;RNA-Binding Proteins;Source;standard of care;Structure;Synapses;System;tau Proteins;Techniques;Tertiary Protein Structure;Testing;TEV protease;Thinking;Tissues;Training;Translations

PROJECT_TITLE: Structure and function of mammalian CPEB2 aggregates in normal and AD brain

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS-R]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: CORAL GABLES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Current gaps in understanding the molecular mechanisms linking intraocular pressure to glaucoma pathology can be filled by utilizing a novel spiking ocular hypertension model. I will use this model to determine the role that endogenous neuroinflammation plays in dysfunction and death of retinal ganglion cells after exposure to repetitive mild spikes in intraocular pressure. The results of this project will improve our knowledge of early cellular responses triggered by IOP fluctuations associated with common lifestyle activities, and likely identify new targets for clinical treatment and slowing of glaucoma progression.

PI_NAMEs: SPURLOCK, MARKUS  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Ablation;Acute;acute stress;Affect;Angle-Closure Glaucoma;Antigen-Antibody Complex;Apoptosis;Axonal Transport;Blindness;Blood Pressure;Caffeine;Calcium;Calcium Channel;CASP1 gene;Cell Death;Cell Death Induction;Cell Density;cell injury;Cell Physiology;Cell Separation;Cell surface;Cell Survival;Cessation of life;Chronic;Clinical;Clinical Treatment;Complex;cytokine;Data;Disease;Electrophysiology (science);Electroretinography;endoplasmic reticulum stress;Environmental Wind;Event;Exercise;Exposure to;Eye;Functional disorder;Genes;Genetic;Glaucoma;Head;Human;improved;Inflammasome;Inflammatory;Injury;insight;instrument;Intake;Interleukin-1;Intervention;Ischemia;ischemic injury;Knockout Mice;Knowledge;Life Style;Link;Mechanical Stress;Mechanoreceptors;Metabolic stress;Modality;Modeling;Molecular;mouse model;Mus;neuroinflammation;Neuronal Dysfunction;Neuronal Injury;Neurons;neurotoxic;novel;Ocular Hypertension;Operative Surgical Procedures;Oxidative Stress Induction;Pathology;Pathway interactions;Pattern;Persons;Pharmaceutical Preparations;pharmacologic;Physiologic Intraocular Pressure;Play;pressure;Proteins;receptor;Receptor Signaling;Recurrence;Regulation;Research;response;retinal damage;retinal ganglion cell degeneration;Retinal Ganglion Cells;Risk;Risk Factors;Rodent;Role;sensor;Signal Pathway;Signal Transduction;Stress;Stroke;Surface;Testing;Time;TRPV channel;VDAC1 gene;Vision;Weight Lifting;Wild Type Mouse

PROJECT_TITLE: Role and regulation of inflammasome in the intraocular pressure-induced injury of retinal ganglion cells


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: LITTLE ROCK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE This project is in line with the NEI mission to support research studying visual disorders and their mechanisms. It aims to enhance our knowledge of the mechanisms underlying retinal ischemic diseases including diabetic retinopathy, glaucoma, retinopathy of prematurity, and vein occlusion. Moreover, the project has the potential to translate the cross talk between the arginase pathway and histone deacetylase 3 in myeloid cells as a new therapeutic target for these retinal disorders.

PI_NAMEs: FOUDA, ABDELRAHMAN  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Abbreviations;Academia;Anabolism;ARG2 gene;arginase;Arginine;arm;Award;Bioenergetics;Blindness;Blood Vessels;career;career development;Career Mobility;Cells;Cessation of life;chromatin modification;Chronic;Clinical;Data;diabetic;Diabetic Retinopathy;Disease;effective therapy;Enzymes;Flow Cytometry;Functional disorder;Genetic Transcription;Glaucoma;Goals;Grant;HDAC3 gene;Histone Deacetylase;Immune;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;Institution;Interleukin-1 beta;Investigational Drugs;Ischemia;ischemic injury;knock-down;Knockout Mice;Knowledge;Laboratories;Laboratory Finding;Macrophage;Mass Spectrum Analysis;Mediating;Mediator;Mentors;Metabolic;Metabolism;Mission;Mitochondria;Mus;Myelogenous;Myeloid Cells;Nerve Degeneration;Neuronal Injury;neuroprotection;neurovascular;neurovascular injury;new therapeutic target;Nitric Oxide;Nitric Oxide Synthase;NOS2A gene;novel;novel therapeutics;Ornithine;Ornithine Decarboxylase;Outcome;Oxidative Stress;Paper;Pathologic Processes;Pathology;Pathway interactions;Pattern;Phase;Phenotype;Polyamines;Production;programs;protective effect;Protein Isoforms;Publishing;Putrescine;Recombinants;repair function;Reperfusion Injury;Reperfusion Therapy;Research;Research Personnel;research study;Research Support;Retina;Retinal Diseases;retinal ischemia;retinal neuron;Retinopathy of Prematurity;Role;Science;Secure;Signal Transduction;skill acquisition;Stress;Testing;Therapeutic;TNF gene;Training;Translating;Translational Research;Up-Regulation;Urea;urea cycle;Vascular Diseases;vascular injury;vein occlusion;Vision Disorders;Vision research;vision science

PROJECT_TITLE: Role of Arginase 1 in Retinal Ischemia-Reperfusion Injury

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: The proposed research is relevant to Veterans because they are at higher risk for tauopathies, and this proposal aims to establish the consequences of the association of tau and frontotemporal dementia, a devastating tauopathy. The expected results will inform future efforts to clarify the relationship between tau and ribosomes on memory decline, a common symptom of virtually all dementias. Therefore, the proposed research is relevant to the NIH mission.

PI_NAMEs: ABISAMBRA, JOSE FRANCISCO (contact)

PROJECT_TERMS: Affect;Affinity;aging population;Alzheimer's Disease;Biological Assay;Brain;brain dysfunction;brain tissue;Cell Physiology;Cells;Chromosome 17;Cognitive;common symptom;Complex;Data;Dementia;design;Development;Disease;effective therapy;Frontotemporal Dementia;Functional disorder;Future;Genetic;Goals;high risk;Human;Impairment;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;innovation;Knockout Mice;Knowledge;Link;Maps;Measures;Mediating;Memory;Memory impairment;Memory Loss;Messenger RNA;Microtubule Stabilization;Mission;Modeling;Molecular;mouse model;Mus;Mutation;Neuronal Dysfunction;novel;novel therapeutic intervention;Organ;overexpression;Pathogenesis;Pathologic;Pathology;Persons;Physiologic pulse;Protein Biosynthesis;Proteins;Proteomics;Publishing;Puromycin;Recombinant Proteins;Recombinants;Regulation;Research;Ribosomal Interaction;Ribosomal Proteins;Ribosomes;Risk;RNA;RNA-Binding Proteins;Screening procedure;Symptoms;targeted treatment;tau aggregation;tau expression;tau mutation;tau Proteins;Tauopathies;Testing;therapeutic target;trafficking;Transcript;Translating;translation factor;Translational Repression;Translations;translatome;United States National Institutes of Health;Veterans;virtual;Work

PROJECT_TITLE: Contributions of tau-mediated translational dysregulation to pathogenesis and progression of fronto-temporal dementia


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: Project Narrative This grant aims to understand the molecular and regulatory details of how a novel and conserved subfamily of heme-binding proteins responds to glyoxal-related toxicity. The data derived from this work is expected to shed light on the understudied area of glyoxal induced cellular stress, and how it regulates cellular metabolic changes and disease.

PI_NAMEs: ULIJASZ, ANDREW T (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Aging;Amino Acids;Anabolism;Antibiotics;antimicrobial;Area;Arginine;Atherosclerosis;Bacteria;Binding;Binding Proteins;biological adaptation to stress;Biological Assay;Calcium-Binding Proteins;cell envelope;Cells;Cellular Stress;Cellular Structures;Complex;Crystallography;Cysteine;Darkness;Data;Dedications;Diabetes Mellitus;Disease;Drug Metabolic Detoxication;Enzymes;Eukaryota;Excision;experimental study;Family;Fluorescence Resonance Energy Transfer;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;Glycolysis;Glyoxal;Goals;Grant;Growth;Health;Heart Diseases;Heme;heme-binding protein;Histidine;Homeostasis;Homologous Gene;Human;human disease;Hypertension;Iron;Knowledge;Life;Literature;Longevity;Lysine;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Membrane;Metabolic;Metabolism;Methods;Mixed Function Oxygenases;Modification;Molecular;mutant;Mutation;Names;Nature;Nerve Degeneration;Nervous System Disorder;Neurons;novel;novel antibiotic class;Nuclear Magnetic Resonance;Nutrient availability;Operon;Organism;Oxidative Stress;pathogenic bacteria;Pathway interactions;Pattern;Planet Earth;Polysaccharides;Predisposition;Process;protein function;Proteins;Pseudomonas;Pseudomonas aeruginosa;Pyruvaldehyde;Quinolones;quorum sensing;Regulation;remediation;Research;response;Role;Side;Signal Pathway;Signal Transduction;stem;Stress;Structure;superresolution imaging;superresolution microscopy;System;Techniques;Time;Toxic effect;Toxin;transcriptome sequencing;uptake;Vesicle;virtual;Virulence Factors;Work

PROJECT_TITLE: A novel family of conserved glyoxal toxicity response proteins.

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative: This proposal is designed to understand how a post-transcriptional mechanism that determines mRNA fate by altering mRNA length contributes to timely and efficient differentiation of macrophages. These cells of the innate immune system are critical for combating infections and for tissue repair, but blocks to their differentiation can lead to leukemias. Thus, the proposed research is relevant to the part of NIH's mission that pertains to advancing fundamental knowledge of important cell processes that could lead to novel treatment strategies for human disease.

PI_NAMEs: MOORE, CLAIRE L (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: 3' Untranslated Regions;Abate;Acute leukemia;Acute Myelocytic Leukemia;Address;Adult;Affect;Antigen Presentation;Binding Sites;Biology;Cell Cycle;Cell Differentiation process;Cell Physiology;Cell Proliferation;cell type;Cells;Code;Consensus;cytokine;Data;Degenerative Disorder;design;Disease;Effector Cell;Ensure;experience;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide;Global Change;Goals;human disease;Immune system;immunoregulation;Infection;Inflammatory;Innate Immune System;knock-down;Knowledge;Length;leukemia;Macrophage;Malignant Neoplasms;Maps;Messenger RNA;Microbe;migration;Mission;Modeling;Molecular;mRNA Precursor;neoplastic cell;novel;novel therapeutics;overexpression;Pathology;Pathway interactions;Pattern;Phagocytosis;Play;Poly(A) Tail;Polyadenylation;Polyadenylation Pathway;Positioning Attribute;posttranscriptional;precursor cell;Process;Production;Proliferating;protein function;Protein Isoforms;Proteins;Regulation;Reporter;Research;response;RNA;RNA Stability;Role;Sequence Analysis;Site;Survival Rate;System;Tail;Testing;Therapeutic;tissue repair;Tissues;tool;transcriptome sequencing;Translations;treatment strategy;trend;tumor progression;United States National Institutes of Health;whole genome

PROJECT_TITLE: Defining the Role of Alternative Polyadenylation in Macrophage Differentiation and Function

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: Asthma;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Machine Learning and Artificial Intelligence;Patient Safety;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE This application will use high-dimensional and longitudinal KPSC EHR data collected retrospectively to identify potential risk factors for asthma exacerbation and subsequently develop and validate a risk prediction model based on electronic health records (EHR) in intermittent asthma patients. The application will also establish a prospective cohort of patients with intermittent asthma and collect patient-reported information (PRI) via survey to further characterize the patients and to develop a risk prediction model based on both EHR and PRI. Our findings present opportunities to provide personalized care (e.g., develop or adjust treatment plans, provide personal asthma action plans accordingly, and refer patients to asthma specialists when necessary) for all and for specific racial/ethnic groups and thus improve the quality of care and reduce asthma burden in this growing population.

PI_NAMEs: CHEN, WANSU  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Acute;Adrenal Cortex Hormones;Affect;Age;Air;Air Pollutants;American;Anxiety;Asthma;asthma exacerbation;asthma inhaler;asthmatic patient;Belief;burden of illness;California;Caring;Categories;Chest;Chronic;Classification;Clinical;community-level factor;Complex;Comprehensive Health Care;Consultations;Coughing;Crime;Data;Data Sources;deep learning;Disease Management;Economic Burden;Electronic Health Record;Emergency Situation;ethnic diversity;Ethnic Population;Etiology;evidence base;Frequencies;Future;Guidelines;health care service;health care service organization;health plan;Health Surveys;Heterogeneity;high dimensionality;high risk;high risk population;Impairment;improved;individual patient;Inflammatory;insight;Integrated Health Care Systems;Intervention;Joints;Knowledge;Machine Learning;Measures;Medical;Medical center;Medicine;Mental Depression;Methods;model development;Modeling;multi-ethnic;Neighborhoods;Oral;patient stratification;Patients;personalized approach;personalized care;personalized management;personalized risk prediction;Pharmaceutical Preparations;Phenotype;Physicians;Population;predictive modeling;predictive tools;Prevalence;Productivity;prospective;Prospective cohort;Provider;Publishing;pulmonary function;Pulmonary function tests;Quality of Care;racial diversity;racial population;Reporting;Research;Retrospective cohort study;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;Severities;sex;Shortness of Breath;social health determinants;Specialist;Surveys;Symptoms;Terminology;Time;Translations;treatment planning;violent crime;Wheezing;Work

PROJECT_TITLE: Predicting Exacerbations of Asthma in Real-World Patients with Low Medical Utilization (PEARL)

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The increasing incidence of youth-onset type 2 diabetes (YoT2D), disproportionately affecting racial and ethnic minority youth often with multiple socioeconomic stressors, is a major public health concern. YoT2D has increased complications, rapid progression, and high rates of treatment failure compared to adult T2D, but the risk factors and pathophysiologic drivers that cause certain youth to progress to YoT2D are not fully understood. This multi-site consortium will follow a cohort of early pubertal youth with prediabetes over three years to investigate which risk factors best predict progression to YoT2D, and clarify the early pathophysiology of YoT2D development, in order to create improved prevention and early treatment strategies.

PI_NAMEs: MAGGE, SHEELA NATESH (contact)

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: 13 year old;14 year old;adipokines;Adolescent;Adult;Adult Children;adverse childhood events;Affect;African ancestry;Age;Asian;B-Lymphocytes;Baltimore;Behavioral;Beta Cell;Black Populations;Black race;Blood Pressure;Body Composition;Body mass index;boys;cardiovascular risk factor;Cardiovascular system;care providers;Cell Physiology;Cell secretion;Child;Childhood;children of color;Chronic stress;Clinic;Clinical Research;Clinical Trials;clinically relevant;cohort;Communities;Continuous Glucose Monitor;Coupled;depressive symptoms;Development;diabetes prevention program;diabetes risk;Diagnosis;Diet;Disease;Dual-Energy X-Ray Absorptiometry;early onset;Early treatment;Education;Endocrinology;Enrollment;Epigenetic Process;ethnic diversity;ethnic minority;Ethnic Origin;European ancestry;experience;Failure;Family;Family history of;fasting glucose;Fatty acid glycerol esters;Fatty Liver;fitness;Florida;Functional disorder;Future;Genetic;genetic risk factor;girls;Glucagon;Glucose;Glycosylated hemoglobin A;health care availability;health care disparity;Health system;Hepatic;High Density Lipoproteins;high school;Hispanic;Hispanic Populations;Hour;Impaired fasting glycaemia;impaired glucose tolerance;Impairment;improved;in vivo;Incidence;Income;Inflammatory;innovation;Insulin;Insulin Resistance;Kinetics;Learning;Life;Lipids;Longitudinal cohort;Low income;mathematical model;Measures;Metabolic;metabolic phenotype;Metformin;Methodology;Microvascular Dysfunction;Minority;minority children;Minority Groups;Minority Health Research;Modeling;Morbidity - disease rate;multidisciplinary;neighborhood disadvantage;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Not Hispanic or Latino;novel;Obesity;obesity in children;OGTT;Outcome;Overweight;Pacific Islander;pandemic disease;Parents;particle;Patient Self-Report;pediatrician;Pharmacotherapy;Phenotype;Physical activity;Physiological;Prediabetes syndrome;predictive modeling;preservation;Prevalence;Prevention;Prevention strategy;Primary Care;progression risk;Puberty;Public Health;Race;racial diversity;racial minority;Recording of previous events;recruit;retention rate;Risk;Risk Factors;risk variant;Site;social;social health determinants;socioeconomic disadvantage;socioeconomic disparity;socioeconomics;Source;South Asian;statistics;stressor;Techniques;Testing;Treatment Failure;treatment strategy;Trust;trustworthiness;Visceral;Youth

PROJECT_TITLE: The PRIORITY Study: from PRedIctiOn to pReventIon of youth-onset TYpe 2 diabetes


ORG_CITY: MINNEAPOLIS

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Regulatory T cells play an important role in preventing autoimmune disease. We have discovered a new type of regulatory T cell that we believe has evolved to deal with two specific types of autoimmune disease – namely dampening immune responses following viral infections, thereby preventing excessive immune- mediated tissue damage, and autoimmune disease, such as lupus, which are characterized by high amounts of interferon. The studies proposed in this grant will test this hypothesis.

PI_NAMEs: FARRAR, MICHAEL ARCHIBALD (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 1918 influenza pandemic;Affect;Antigens;Autoantigens;Autoimmune Diseases;Autoimmunity;Bacteria;Cell Physiology;cell type;Cells;Cellular biology;Complex;Coronavirus;Cytoprotection;Data;Dendritic Cells;Development;Disease;FOXP3 gene;Funding;Gene Expression;Genes;genetic signature;Grant;Hybridomas;IL2RA gene;Imiquimod;Immune;Immune response;Immune Tolerance;in vivo;Infectious Agent;Inflammation;Influenza;influenza infection;Interferon Type I;Interferons;LoxP-flanked allele;Lupus;Mediating;migration;Modeling;mouse model;Mus;novel;Organism;pandemic influenza;pathogen;Pathogenicity;Pathology;Peptides;Play;prevent;Prevention;Process;progenitor;programs;reduce symptoms;Regulatory T-Lymphocyte;response;Role;secondary lymphoid organ;Signal Transduction;single-cell RNA sequencing;Sjogren's Syndrome;Source;Specificity;STAT1 gene;stem cells;Stromal Cells;Structure of parenchyma of lung;Systemic Lupus Erythematosus;T-Cell Development;T-Cell Receptor Genes;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Thymic epithelial cell;Thymus Gland;Tissues;transcriptomics;TYRP1 gene;Up-Regulation;Viral;Virus;Virus Diseases;Visualization

PROJECT_TITLE: Development of Immune Tolerance

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Chronic Pain;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Opioids;Pain Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE A substantial neuroimmune overlap exists between preclinical evidence of prenatal alcohol exposure (PAE) and opioid-mediated immune actions with convergence suspected to occur upon activation of the innate immune receptor, TLR4, resulting in proinflammatory cytokine and neurological dysfunction. A strikingly similar mechanism is observed from PAE-primed glial-immune actions from a minor nerve injury, supporting the application in this proposal of a mouse model of PAE to understand how exaggerated TLR4 activation is engaged following morphine exposure for treating pain that paradoxically prolongs pathological pain states such as allodynia. Identifying mechanisms underlying morphine’s proinflammatory effects worsening allodynia rather than suppressing it in PAE offspring is critical as clinical research suggests that individuals with a history of PAE are more likely to engage in substance use disorders, and a biological vulnerability to develop adverse neuroimmune interactions from opioids exposure may play a role, in part, to future opioid misuse.

PI_NAMEs: NOOR, SHAHANI  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Acute;Adult;Alcohol abuse;alcohol exposure;Alcohols;allodynia;Animal Model;antagonist;Astrocytes;Behavioral;Biological;cell type;Cells;Central Nervous System;Chronic;chronic pain management;circular RNA;Clinical;Clinical Research;Cognitive;Curiosities;cytokine;Data;Disease susceptibility;Dose;Down-Regulation;Endogenous Factors;enhancing factor;Etiology;Evaluation;Family;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Functional disorder;Future;Gene Expression Profiling;Goals;High Prevalence;Hyperalgesia;Immune;Immune System Diseases;Immunologic Receptors;in vivo;Individual;Infiltration;Inflammasome;Inflammatory;Injury;Interleukin-1 beta;Investigation;late life;Light;Macrophage;Macrophage Activation;marenostrin;Mediating;Messenger RNA;Minor;Modeling;Morphine;mouse model;mu opioid receptors;Mus;Naloxone;Nerve;nerve injury;neurobehavioral;Neuroglia;Neuroimmune;Neurologic Dysfunctions;novel;offspring;Opioid;opioid exposure;opioid misuse;Outcome;overexpression;Pain;Pain management;Pathologic;Pathology;Pathway interactions;Peripheral;Physiological Adaptation;Population;pre-clinical;Predisposition;Pregnancy;Prevalence;Process;Production;Proteins;Public Health;Rattus;receptor;Receptor Activation;Receptor Signaling;Recording of previous events;response;Risk;Risk Factors;risk mitigation;Role;Signal Transduction;single-cell RNA sequencing;Spinal;stem;Substance abuse problem;substance use;Substance Use Disorder;Therapeutic;TNF gene;Toll-like receptors;Touch sensation;Transcription Initiation;Untranslated RNA;Work

PROJECT_TITLE: Prenatal alcohol exposure generates vulnerability to the proinflammatory effects of morphine and adverse neuroimmune consequences

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative Through long-range DNA looping interaction, genetic variants in non-coding DNA can lead to gene misregulation and human diseases. We will comprehensively study on how DNA variants affect the DNA looping using mouse pancreatic β cells as a model system. This study will advance our understanding of the genome function in the context of 3D space and provide a launch pad for future human studies.

PI_NAMEs: ATTIE, ALAN D;JIN, FULAI  (contact);LI, YAN

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: 3-Dimensional;Address;Affect;Alleles;Architecture;ATAC-seq;Beta Cell;Binding;Binding Sites;bioinformatics tool;Biological;Biological Models;Biology;Budgets;Cell Line;Cell Physiology;cell type;Cells;Chromatin;Chromatin Loop;chromosome conformation capture;Cohort Studies;Collection;Complex;cost;CRISPR screen;Data;data resource;deep learning;deep sequencing;Diabetes Mellitus;Disease;DNA;DNA Sequence;Enhancers;Epigenetic Process;epigenome;epigenomics;Etiology;Euchromatin;Event;functional genomics;Future;Gene Expression;Genes;Genetic;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;genomic data;Genotype;Goals;Heritability;Heterochromatin;Heterozygote;Hi-C;Human;Human Biology;human disease;Human Genome;Hybrids;improved;In Situ;in vivo;Inbred Strains Mice;insight;Insulin Antibodies;invention;islet;Islets of Langerhans;Knowledge;Literature;male;Mammalian Genetics;mammalian genome;Maps;Methods;Modeling;Modernization;Molecular;mouse genetics;Mouse Strains;Multiomic Data;Mus;Names;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;Phenotype;Physiological;Population;promoter;Property;Publishing;Quantitative Trait Loci;Regulatory Element;Reporting;Research;Resolution;Role;single cell ATAC-seq;single-cell RNA sequencing;Sorting;Structure;Structure of beta Cell of islet;Surveys;Technology;Time;Tissues;tool;trait;Transcriptional Regulation;transcriptome;Translating;Untranslated RNA;Variant;Visualization;Work;XCL1 gene

PROJECT_TITLE: Mapping heritable chromatin loop variants with allele-specific Hi-C analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(02)M]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

PHR: Project Narrative  Fundamental questions about membrane protein structure and function are still unanswered. Novel technologies and genetic tools are required to advance our mechanistic understanding about the action of these systems in both normal and diseased states. Our studies will reveal fundamental insights about the visual system and will reveal novel strategies to combat retinal disease.

PI_NAMEs: PARK, PAUL S (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Adopted;Atomic Force Microscopy;autosome;Biochemical;Biochemical Reaction;Biological Assay;Biological Process;Biophysics;blue cone monochromacy;Cell Physiology;Cells;Cellular biology;Chemicals;Classification;Clinical;combat;Cone;Defect;Disease;effective therapy;Equilibrium;Event;Fluorescence Resonance Energy Transfer;Functional disorder;G-Protein-Coupled Receptors;Gene Modified;Genes;Genetic;Goals;Health;Hot Spot;In Vitro;in vivo;Inherited;innovation;insight;Knock-in Mouse;Knowledge;Light;Link;member;Membrane;Membrane Proteins;Methods;Molecular;Molecular Chaperones;mouse model;Mus;mutant;Mutation;nano;nanoscale;Nature;new technology;new therapeutic target;Night Blindness;novel;novel strategies;Opsin;Pathogenesis;Phenotype;photoreceptor cell outer segment;Photoreceptors;Phototransduction;Physiological;Physiology;Play;Point Mutation;prevent;Process;programs;Property;protein function;protein structure;Proteins;receptor;Receptor Activation;Research;response;Retina;Retinal Degeneration;Retinal Diseases;retinal rods;Retinitis Pigmentosa;Retinoids;Rhodopsin;Rod;rod outer segment disc;Rod Outer Segments;Role;Scheme;Scientific Inquiry;Severities;Signal Transduction;Site;Structure;success;System;targeted treatment;Testing;three dimensional structure;tool;Vision;Vision Disorders;Visual System;Visualization

PROJECT_TITLE: PHOTOTRANSDUCTION IN HEALTH AND DISEASE

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative  As the cost of DNA sequencing has become increasingly affordable in the past decade, the amount of genomic data procured for a typical biomedical research project has grown rapidly. As a result, it is becoming increasingly essential for the scientists  conducting the biomedical research to have the core computational skills required to perform the appropriate analyses for their experiments. Our proposed courses will teach these researchers (1) how to use the appropriate workflows for each type of dataset/experiment, (2) how the tools work under the hood, and (3) how to interpret the results of these workflows in a biomedically-meaningful way.

PI_NAMEs: PEVZNER, PAVEL A (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Address;Algorithms;Big Data;Bioinformatics;Biological;biological research;Biological Sciences;Biomedical Research;Bypass;Communities;Computational Biology;cost;Data Analyses;Data Set;Development;DNA sequencing;E-learning;Education;education research;Educational Curriculum;Educational process of instructing;Event;experience;experimental study;Exposure to;Funding Opportunities;genomic data;Genomics;Goals;Individual;innovation;instructor;Journals;Learning;Methods;Modernization;online resource;Paper;Patient Recruitments;Problem Solving;professor;Publishing;Research Personnel;Research Project Grants;Resources;response;science education;Scientist;skills;Software Tools;Students;symposium;Textbooks;Time;tool;Underrepresented Minority;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: DEVELOPMENT OF ONLINE COMPUTATIONAL GENOMICS SPECIALIZATION

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]