NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The proposed research will elucidate the basic molecular mechanisms underlying cilia- dependent vertebrate Hedgehog pathway, an essential cell-signaling pathway required for embryonic development and adult tissue homeostasis. The fundamental knowledge gained through this work is expected to aid research that is aimed at development of therapeutic agents to combat birth defects and human cancers linked to errors in this pathway.

PI_NAMEs: SUBRAMANIAN, RADHIKA  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Acceleration;Adult;Basal cell carcinoma;base;Binding;Binding Proteins;Binding Sites;Biochemical;Biological;Biological Assay;Biology;Catalytic Domain;Cell Nucleus;Cell Physiology;Cell surface;Cells;Cilia;Cilium Microtubule;combat;Complex;Congenital Abnormality;Craniofacial Abnormalities;Cyclic AMP-Dependent Protein Kinases;Cytoplasm;Data;developmental disease;Distal;Embryonic Development;Erinaceidae;experience;gene repression;Genetic Transcription;Glioma;Goals;hedgehog signal transduction;Hedgehog signaling complex location;Homeostasis;Human;Image;imaging modality;Impairment;Importins;In Vitro;insight;Kinesin;Knowledge;Link;Location;malformation;Malignant Neoplasms;Mediating;Medulloblastoma;Microtubules;Molecular;Mutagenesis;Mutation;Newborn Infant;Nuclear;Nuclear Import;Nuclear Localization Signal;Nuclear Proteins;Nuclear Translocation;Oncogenes;Oncoproteins;Organelles;Output;Pathway interactions;Phosphotransferases;Plus End of the Microtubule;Positioning Attribute;prevent;Process;programs;Property;protein complex;Protein Dynamics;protein protein interaction;Proteins;Protocols documentation;Reaction;real-time images;Recombinant Proteins;reconstitution;recruit;Regulation;Research;Resolution;scaffold;Series;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Protein;single molecule;Site;skeletal;smoothened signaling pathway;Structure;Techniques;Therapeutic;therapeutic development;Time;Tissues;Total Internal Reflection Fluorescent;Transcription Coactivator;transcription factor;Transcription Factor Oncogene;tumor;Visualization;Work

PROJECT_TITLE: Protein dynamics underlying cilium-dependent Hedgehog signaling

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: LM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Pediatric

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Meta-analyses shape clinical recommendations and policy, so it is critical to understand the extent to which their conclusions remain credible given the numerous biases that can affect their constituent studies. The current project will develop statistical methods that help rigorously characterize the credibility of individual meta-analyses by accounting flexibly for multiple biases, and that forecast the results of new studies based on potentially biased meta-analyses. This project will rigorously calibrate confidence in health-relevant conclusions from individual meta- analyses.

PI_NAMEs: MATHUR, MAYA  (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TITLE: Statistical Methods for Modern Evidence Syntheses with Multiple Biases

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Biomedical Imaging;Lung;Rare Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Not applicable to Scientific Core.

PI_NAMEs: MO, GARY CH (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Address;Algorithms;Animals;Anti-Inflammatory Agents;beta catenin;Biosensing Techniques;Biosensor;Cell Size;Cell surface;Cells;cellular imaging;Color;Concentration Camps;CREB1 gene;Cues;Cyclic AMP;Development;Diameter;Dissection;Environment;Family;Flow Cytometry;Functional Imaging;Genetic Transcription;Goals;Grain;Heterogeneity;Image;imaging approach;imaging study;Immune;In Situ;In Vitro;in vivo;Inflammation;Inflammatory;Injury;insight;interest;intravital imaging;intravital microscopy;Janus kinase;Kinetics;Lung;lung imaging;lung injury;lung repair;Macrophage;Macrophage Activation;Metabolic;Metabolism;Methodology;Methods;migration;Molecular;Monitor;Morphologic artifacts;Motion;Mus;Myelogenous;Myeloid Cells;novel;novel strategies;Outcome;Paracrine Communication;Pathway interactions;Pattern;Phase;Phosphorylation;Phosphotransferases;Process;programs;Property;protein kinase A kinase;Proteins;Reagent;Recovery;Regulation;Resolution;respiratory;response;Signal Pathway;Signal Transduction;Sorting;Source;spatiotemporal;STAT protein;Substrate Interaction;success;superresolution microscopy;Surface;Testing;Time;Tissues;tool;transcription factor;two-photon;ultra high resolution;Variant;Visual

PROJECT_TITLE: Advanced Imaging Core

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHARLESTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: While it was initially believed that only a minority of CRC are driven by inflammation, studies showing that treatment with anti-inflammatory medications may prevent or delay the development of CRC in hereditary and sporadic cases, clearly identify inflammation as a key driver in the development and progression of all types of CRC. Yet, it is still unclear what are the mechanisms that in the complex intestinal environment contribute to the activation of the inflammatory pathways that initiate CRC. Our finding that the downregulation of the complement C3aR down-regulation may be an early event that causes CRC development in human and in our novel mouse model, suggest that identifying the mechanisms linking loss of C3aR to the development of CRC will not only further our understanding of CRC but is highly significant for the prevention of CRC.

PI_NAMEs: GUGLIETTA, SILVIA  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Affect;Anaphylatoxins;Anti-Bacterial Agents;Anti-Inflammatory Agents;APC gene;ApcMin/+ mice;Automobile Driving;Bioinformatics;Biological Assay;Biology;Bone Marrow;C3AR1 gene;cancer initiation;cell type;Cells;Characteristics;Chimera organism;Coculture Techniques;cohort;Colon;Colon Carcinoma;Colonic inflammation;Colonic Neoplasms;Colorectal Cancer;colorectal cancer prevention;Communication;Complement;Complement 3a;complement C3a receptor;complement system;Complex;cytokine;Cytometry;Data;Data Set;Development;dimensional analysis;Down-Regulation;dysbiosis;Environment;Epidemiology;Epithelium;Equilibrium;Event;experimental study;fecal transplantation;follow-up;Functional disorder;Gastrointestinal tract structure;Gatekeeping;Health;high dimensionality;Human;Image;Immune;immune cell infiltrate;immune function;Immune response;Immune system;Inflammation;Inflammatory;Inherited;intestinal barrier;intestinal epithelium;intestinal homeostasis;intestinal tumorigenesis;Intestines;Invasive Lesion;Investigation;Lesion;Link;Measures;mesenteric lymph node;Methylation;microbial;Microbiology;microbiota;Mining;Minority;Modeling;Molecular;monolayer;mouse model;Mucosal Immune Responses;Mucous Membrane;multidisciplinary;Mus;Mutation;Natural Immunity;novel;Organoids;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;prevent;Process;Production;Property;receptor;Research Personnel;response;Role;Seminal;Small Intestines;Specimen;Testing;tumor;tumor microenvironment;tumorigenesis;tumorigenic;Work

PROJECT_TITLE: Role of the complement C3a receptor on immune and non immune intestinal barrier functions and microbiota in colorectal cancer development

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biotechnology;Clinical Research;Genetics;Hematology;Human Genome;Infectious Diseases;Lung;Rare Diseases;Sepsis

PI_NAMEs: DUDEK, STEVEN M (contact)

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;African American;biobank;Bioinformatics;Biometry;Blood;Blood specimen;Bronchoalveolar Lavage;Categories;Clinical;Clinical Data;clinical database;clinical phenotype;Code;Critical Illness;Data;Development;Diagnostic;Disease Outcome;Doctor of Philosophy;Enrollment;Etiology;Excision;Genomics;Hispanic;Human;Human Resources;Immune Tolerance;improved;Individual;Inflammatory;Informatics;innovation;Institution;Institutional Review Boards;Latino;Lung;lung injury;Lymphocyte;Macrophage;Mechanical ventilation;Mediating;Medicine;Methodology;novel strategies;Pathway interactions;patient population;patient subsets;Patients;Peripheral Blood Mononuclear Cell;Pharmacology;Phase;Phenotype;Pneumonia;Population;Process;professor;programs;Protocols documentation;Pulmonology;repaired;Reporting;repository;Research;Research Personnel;Resolution;Resources;respiratory;Role;Safety;sample collection;Sampling;Sepsis;sepsis induced ARDS;Severities;Severity of illness;single-cell RNA sequencing;Specialist;Specimen;Structure;Syndrome;transcriptome sequencing;transcriptomics;treatment response;Underrepresented Populations;Universities;Work

PROJECT_TITLE: Patient Sampling and Genomics Core


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHICAGO

ORG_DEPT: UROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: OVERALL: PROJECT NARRATIVE The SPORE in Prostate Cancer brings together basic scientists, clinicians, pathologists, biostatisticians, bioinformaticists and advocates who together will work to improve the outcome of patients with prostate cancer through experiments to understand the basic biology and through the design and conduct of innovative paradigm-shifting clinical trials.

PI_NAMEs: ABDULKADIR, SARKI A. (contact);HUSSAIN, MAHA H

PROGRAM_OFFICER_NAME: SCROGGINS, BRADLEY TODD

PROJECT_TERMS: Advocacy;Advocate;Aggressive course;American;androgen independent prostate cancer;anti-cancer research;Antibody Therapy;Antitumor Response;Basic Science;Bioinformatics;Biology;Biometry;Biopsy Specimen;Blood specimen;bone;c-myc Genes;Cancer Etiology;cancer genetics;Cancer Patient;career;Catchment Area;Chicago;Clinical;Clinical Sciences;Clinical Trials;cohort;Collaborations;Combined Modality Therapy;Comprehensive Cancer Center;Core Facility;Dedications;design;Development;Diagnosis;Disease;DNA Damage;efficacy evaluation;experience;experimental study;Family member;FDA approved;Focus Groups;Friends;Funding;Genetic Transcription;Health;Health system;Human;humanized monoclonal antibodies;immune checkpoint blockade;Immune system;Immunotherapy;improved;improved outcome;Infrastructure;inhibitor;innovation;Innovative Therapy;Institution;investigator-initiated trial;Leadership;Malignant neoplasm of prostate;Measurable;Measures;Mediating;member;men;Metastatic Prostate Cancer;MHC Class I Genes;mortality;mouse model;Myelogenous;National Cancer Institute;new technology;novel;novel strategies;novel therapeutics;Oncogenic;Pathologist;Pathway interactions;Patient Care;patient population;Patient-Focused Outcomes;Patients;Pharmacologic Substance;Phase I Clinical Trials;Phosphorylation;PIK3CG gene;Poly(ADP-ribose) Polymerase Inhibitor;Pre-Clinical Model;pre-Investigational New Drug meeting;preclinical study;programmed cell death protein 1;programs;prostate cancer model;Prostate specific antigen measurement;PTEN gene;Qualifying;Quality of life;recruit;Regulation;Rejuvenation;Research;Research Personnel;Research Project Grants;Resistance;safety study;Scientist;Signal Transduction;Source;STING agonists;success;T cell infiltration;T-Cell Activation Pathway;Talents;targeted treatment;Testing;Therapeutic;Tissues;Translating;Translational Research;Translations;Treatment Efficacy;tumor;tumor microenvironment;tumor-immune system interactions;Universities;Visceral;Work

PROJECT_TITLE: SPORE in Prostate Cancer


PHR: CORE A: NARRATIVE The SPORE Administrative, Leadership Development and Advocacy (Admin) Core provides integration and strong leadership and coordinates oversight of projects and cores to ensure that scientific objectives are accomplished such that the SPORE can have the greatest impact on patients with prostate cancer.

PI_NAMEs: ABDULKADIR, SARKI A. (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Advocacy;anti-cancer research;Cancer Center;Cancer health equity;career;Chicago;Collaborations;Communities;Comprehensive Cancer Center;Dedications;Department of Defense;Development;Diagnosis;Education;Ensure;Evaluation;Foundations;Funding;Health system;improved outcome;innovation;Intervention;Laboratory Scientists;Lead;Leadership;leadership development;Malignant neoplasm of prostate;Medical Oncologist;multidisciplinary;next generation;organizational structure;Pathologist;Patient-Focused Outcomes;Patients;Productivity;programs;Research;Research Personnel;Research Project Grants;Structure;Testing;Training;Translational Research;United States National Institutes of Health;Universities;Urologist

PROJECT_TITLE: Administrative, Leadership Development and Advocacy Core


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Lung;Rare Diseases;Regenerative Medicine

PHR: Not applicable to individual Projects.

PI_NAMEs: KIM, KIWOOK  (contact)

PROJECT_TERMS: Abbreviations;Address;Anti-Inflammatory Agents;calmodulin-dependent protein kinase II;Cells;Collaborations;CREB1 gene;Cyclic AMP-Responsive DNA-Binding Protein;Data;Electrophysiology (science);extracellular;Gene Deletion;Heterogeneity;Individual;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Injury;innate immune function;Innate Immune Response;inward rectifier potassium channel;Ion Channel;Ions;Lead;Left;Ligands;Lung;lung injury;lung repair;Macrophage;Mediating;Metabolic;meter;Microbe;Modeling;novel;Oncogenes;optogenetics;Pathway interactions;Patients;Phenotype;Potassium;Potassium Channel;programs;pulmonary function;Purinoceptor;Regulation;Resolution;response;Role;Rous Sarcoma;Signal Pathway;Signal Transduction;SRC gene;STAT1 gene;STAT1 protein;STAT6 gene;STAT6 Transcription Factor;success;Testing;Tissues;transcription factor;Transcriptional Activation

PROJECT_TITLE: Ion Flux Regulation of Macrophage Plasticity in Lung Injury and Repair


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative The overall goal of this Center is to uncover and define the mechanisms by which epithelial genes contribute to the development, persistence, progression, remission, and resolution of allergic disorders so that effective strategies can be developed to prevent the onset and/or halt the progression of allergic disease.

PI_NAMEs: KHURANA HERSHEY, GURJIT K. (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Affect;Allergic;Allergic Disease;Allergic inflammation;allergic response;Atopic Dermatitis;Basic Science;Black race;Cellular biology;Child;Childhood Asthma;comorbidity;Data;Data Analyses;data integration;design;Development;Disease;Disease Progression;Disease remission;Doctor of Medicine;Doctor of Philosophy;Educational workshop;empowerment;Environment;epidemiology study;Epithelial Cells;Epithelium;Foundations;Funding;Genes;Goals;Heterogeneity;Homeostasis;Hypersensitivity;IgE;Individual;Inflammatory;Infrastructure;insight;Knowledge;Life;Longitudinal cohort;Molecular;novel;Organ;Pathogenesis;Pathway interactions;Pediatric Hospitals;Peptide Hydrolases;Phenotype;Play;Population;prevent;Prevention strategy;Principal Investigator;prospective;Protease Inhibitor;racial difference;receptor;Regulation;Research Personnel;Resolution;response;Risk;Risk Factors;Role;Serine Proteinase Inhibitors;Skin;Surface;Testing;Therapeutic;therapy development;Tissues;Transcription Repressor;Translational Research;treatment strategy;United States National Institutes of Health;virtual

PROJECT_TITLE: Epithelial Genes in Allergic Inflammation


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: SANTA CRUZ

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: RELEVANCE TO PUBLIC HEALTH Despite decades of research and much progress, certain subtypes of leukemia remain highly resistant to treatment. Our recent work shows that one determinant of the aggressive behavior of leukemia is a protein that regulates post-transcriptional gene expression, insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3). By determining how this protein contributes to leukemia causation and understanding the underlying mechanism, we will define novel diagnostic, prognostic and therapeutic approaches in these highly aggressive malignancies.

PI_NAMEs: RAO, DINESH S;SANFORD, JEREMY ROBERT (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: 3' Splice Site;3' Untranslated Regions;Acute leukemia;Aggressive behavior;Alternative Splicing;Binding;Binding Proteins;Binding Sites;Biological Assay;Biology;Cancer Biology;cancer initiation;cancer type;cell transformation;Cells;Chimeric Proteins;clinical translation;Competitive Binding;conditional knockout;crosslink;Data;Development;Diagnostic;diagnostic value;Disease;Equilibrium;Etiology;experimental study;Fetal Development;Foundations;Gene Combinations;Gene Expression;Gene Expression Regulation;Genes;genetic approach;Genetic Models;Hematologic Neoplasms;Human;IGFBP2 gene;Immunoprecipitation;In Situ;In Vitro;in vivo;insight;insulin regulation;Insulin-Like Growth Factor II;Investigation;Knock-out;Knowledge;leukemia;leukemic stem cell;Maintenance;Malignant - descriptor;Malignant Neoplasms;Measurement;Mediating;Mediator;Messenger RNA;MicroRNAs;migration;Modeling;Molecular;Molecular Biology;mRNA Precursor;mRNA Stability;Mus;Mutation;Nature;novel;novel diagnostics;novel therapeutic intervention;Oncogenic;Oncology;overexpression;Pathogenesis;Play;Post-Transcriptional Regulation;posttranscriptional;Production;Prognosis;prognostic;Proliferating;Protein Isoforms;Proteins;Public Health;Publishing;Regulation;Regulator Genes;Reporter;Research;Resistance;reverse genetics;RNA;RNA Splice Sites;RNA Splicing;RNA Stability;RNA-Binding Proteins;RNA-Induced Silencing Complex;RNA-Protein Interaction;Role;Signal Transduction;Signaling Protein;Site;Solid;stem cells;Structure;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;Transcript;transcription factor;transcriptomics;Translating;Translations;tumorigenesis;Untranslated RNA;Work

PROJECT_TITLE: Protein-RNA interactions in cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGA-P(07)S]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Prostate Cancer;Urologic Diseases

PHR: CORE B: NARRATIVE The Biostatistics and Bioinformatics Core (Core B) has three primary responsibilities: 1) development, maintenance and enhancement of preclinical and clinical database functionality to support all Prostate SPORE Projects; 2) application of state-of-the art bioinformatics pipelines for pre-processing and analysis of high- dimensional omics data; and 3) biostatistical contribution to study design, data analysis and interpretation of results for all preclinical and clinical Prostate SPORE Projects to ensure that all reported program accomplishments undergo rigorous evaluation.

PI_NAMEs: KOCHERGINSKY, MASHA  (contact)

PROJECT_TERMS: Address;Adherence;Affinity;Binding;Bioinformatics;bioinformatics pipeline;Biological;Biometry;Cell Physiology;Cells;Chicago;ChIP-seq;Clinical;Clinical Data;clinical database;clinical trial participant;Clinical Trials;Code;cohort;Collaborations;Complement;Comprehensive Cancer Center;Computer software;Computer Systems;Consultations;Custom;Data;Data Analyses;Data Analytics;data integration;data management;data registry;data resource;Data Science;Data Set;data standards;Databases;Dedications;Development;differential expression;Dose;Ensure;Environment;Evaluation;Experimental Designs;experimental study;Faculty;Fostering;Funding;Gene set enrichment analysis;Genes;genetic manipulation;genome browser;Health system;high dimensionality;High Performance Computing;High-Throughput Nucleotide Sequencing;improved;Individual;innovation;Investigation;Link;Maintenance;Malignant neoplasm of prostate;Maps;medical schools;member;Modification;Molecular;Monitor;Monitoring Clinical Trials;Ontology;Output;Pathway interactions;Patients;Phase I Clinical Trials;pre-clinical;preclinical study;programs;Prostate;Protocols documentation;reference genome;Registries;Reporting;repository;Reproducibility;Research;Research Design;Research Personnel;Safety;Secure;single-cell RNA sequencing;Site;Statistical Data Interpretation;synergism;Techniques;Time;Tissue Sample;Tissues;transcriptome sequencing;Universities;Visualization

PROJECT_TITLE: Biostatistics and Bioinformatics Core


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Ependymomas in children carry a dismal prognosis and have no effective treatment options. We aim to unravel how epigenetic and metabolic pathways are integrated in these tumors. Targeting this integrated pathway will simultaneously tackle two dysfunctional tumor drivers, thus enabling the development of effective therapies.

PI_NAMEs: NAGRATH, DEEPAK ;TAMRAZI, BENITA ;VENNETI, SRIRAM  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Address;Adjuvant;Adjuvant Therapy;Adolescent;Adult;alpha ketoglutarate;Biological;Biological Assay;Biology;Cell Line;Cell Proliferation;Cells;Child;Childhood Ependymoma;ChIP-seq;Chromatin;Citric Acid Cycle;Classification;Clinical;Clinical Trials;Clinical Trials Design;cofactor;combat;Critiques;Data;demethylation;design;Development;Disease;DNA;DNA Modification Process;effective therapy;enzyme pathway;Enzymes;Ependymoma;Epigenetic Process;Exhibits;EZH2 gene;Gene Expression;Genes;Genetic;genome-wide;Genomics;Germ-Line Mutation;Glucose;glucose metabolism;Glycolysis;Goals;Heterogeneity;Hexokinase 2;hindbrain;histone modification;Histones;In Vitro;in vivo;Infant;inhibitor;Interruption;Isocitrate Dehydrogenase;Isotopes;Knowledge;Link;Lysine;Magnetic Resonance Spectroscopy;male;Malignant Neoplasms;Measures;Mediating;Metabolic;metabolic imaging;Metabolic Pathway;Metabolism;Methyltransferase;mitochondrial metabolism;Modification;Molecular;Morbidity - disease rate;mortality;Mutation;neoplastic cell;non-invasive monitor;novel;nutrient metabolism;Oncogenes;Oncogenic;Operative Surgical Procedures;overexpression;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Posterior Fossa;Production;Prognosis;programs;protein expression;Proteins;Protocols documentation;Radiation;Recurrence;Regulation;Research;sex;Somatic Mutation;spectroscopic imaging;standard care;targeted therapy trials;Therapeutic;therapeutic development;therapeutic effectiveness;Treatment Efficacy;Tricarboxylic Acids;tumor;tumor growth;uptake;Work

PROJECT_TITLE: Targeting integrated metabolic and epigenetic pathways in childhood ependymomas

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-J(02)M]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Genetics;Lung;Rare Diseases;Regenerative Medicine

PI_NAMEs: MEHTA, DOLLY  (contact)

PROJECT_TERMS: Acetyl Coenzyme A;Address;Alveolar;Alveolar Macrophages;Anti-Inflammatory Agents;Attenuated;Binding;Cell Nucleus;cell type;Cells;Collaborations;Cyclic AMP Response Element;Data;Epigenetic Process;epigenetic regulation;Generations;Genes;genetic signature;Genetic Transcription;Histone Acetylation;Histones;Homeostasis;Immune;Immune response;Impairment;Individual;Inflammatory;Injury;interstitial;ITGAM gene;ITGAX gene;Lung;Lung infections;lung injury;lung repair;Macrophage;Mediating;Metabolism;Mitochondria;Modeling;monocyte;mortality;Mus;Myelogenous;Nuclear;Pathway interactions;Phenotype;Play;Population;PPAR gamma;prevent;Production;Property;Pyruvate;Pyruvate Dehydrogenase Complex;pyruvate dehydrogenase kinase 4;Regulator Genes;repair function;repair strategy;repaired;Repression;Resolution;Role;Seminal;Sentinel;Signal Transduction;Sorting;Specific qualifier value;STAT6 gene;Testing;tissue repair;tool;transcription factor;Up-Regulation

PROJECT_TITLE: CREB Programming of Alveolar Macrophage Population and Inflammatory Lung Injury


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Prevention

ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Colorectal cancer (CRC) represents a very serious public health concern: in the United States, both men and women have an approximately 1 in 20 chance of developing CRC during their lifetimes, with 50,000 Americans succumbing to CRC annually. The ability of certain human gut bacteria to produce the genotoxic molecule colibactin has been correlated with incidence of CRC in humans and shown to affect CRC development in mice. This research program will elucidate how colibactin interacts with and damages DNA and will develop strategies for inhibiting colibactin production, providing a greater understanding of colibactin's role in CRC and laying the groundwork for new strategies to prevent and treat cancer.

PI_NAMEs: BALSKUS, EMILY PATRICIA (contact)

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: Achievement;Affect;Alkylating Agents;American;Anabolism;Animal Model;animal tissue;Biological;Biology;Boronic Acids;Cancer Biology;Cancer Etiology;cancer initiation;cancer prevention;cancer therapy;carcinogenesis;Cells;Cessation of life;Chemicals;Chromosomal Instability;Colitis associated colorectal cancer;colon cancer patients;colon carcinogenesis;Colorectal Cancer;colorectal cancer prevention;commensal bacteria;Development;Diagnosis;Disease;DNA;DNA Adducts;DNA Damage;DNA Double Strand Break;DNA Interstrand Crosslinking;DNA Sequence Alteration;Enzymes;Escherichia coli;Eukaryotic Cell;Exposure to;Funding;Future;Gene Cluster;Genome;genotoxicity;Goals;Grant;guided inquiry;gut bacteria;gut microbes;gut microbiota;host-associated microbial communities;Human;Human Cell Line;Human Microbiome;In Vitro;in vivo Model;Incidence;Individual;Infection;Inflammatory Bowel Diseases;inhibitor;insight;interdisciplinary approach;Island;Knowledge;Location;Malignant Neoplasms;Mediating;men;Metabolic Pathway;Metabolism;Methods;microbial;microbial community;Microbiology;microbiome research;Molecular;mouse model;murine colitis;Mus;Mutagens;Pathway interactions;Patients;peptide synthase;Physiological;Play;polyketide synthase;Prevalence;prevent;Production;programs;Proteobacteria;Public Health;Research;Role;secondary metabolite;small molecule;small molecule inhibitor;Specificity;structural biology;Structure;Techniques;Toxicology;tumor progression;tumorigenesis;United States;Woman;Work

PROJECT_TITLE: Understanding the Mechanism of a Gut Microbial Genotoxin Involved in Colorectal Carcinogenesis


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Infectious Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative Persons with HIV (PWH) on antiretroviral therapy have an increasing risk of mortality from cardiovascular disease that is likely multifactorial. Chronic inflammation due to co-infection with cytomegalovirus (CMV) alters the memory T cell repertoire and antibody responses and is likely important in the pathogenesis of cardiovascular disease. This proposal focuses on the role of CMV-specific immune cells in the progression of atherosclerotic disease in PWH; aligning with the NIH HIV/AIDS research priorities and NHLBI's mission to investigate newly discovered pathobiological mechanisms important to the onset of atherosclerotic cardiovascular disease and identify factors that account for differences in health among populations.

PI_NAMEs: WANJALLA, CELESTINE N (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;ADGR1 gene;Adult;alpha-beta T-Cell Receptor;Animal Model;antagonist;Antibodies;Antibody Response;antiretroviral therapy;Aorta;Arterial Fatty Streak;Atherosclerosis;Award;Biology;Blood;Blood Vessels;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career development;Cause of Death;CD4 Positive T Lymphocytes;Cell Line;Cell Separation;Cells;Cellular Immunity;chemokine receptor;Chimera organism;Chronic;Clinical Research;co-infection;cohort;Collaborations;Communicable Diseases;Coronary artery;Cytomegalovirus;Data;Development;Development Plans;Disease;Disease Pathway;Endothelium;Engraftment;Epidemiology;Epitopes;Event;Foundations;Funding;health difference;high risk;HIV;HIV Seronegativity;HIV/AIDS;Home;Human;Image;Immune;Immune response;Immunology;immunomodulatory strategy;Implant;Individual;Infiltration;Inflammation;Infrastructure;Institution;Intervention Trial;Intravenous;Knowledge;Label;Leadership;Ligands;Linear Regressions;Link;Measures;Mentored Clinical Scientist Development Program;Mentored Patient-Oriented Research Career Development Award;Mentors;Metabolic Diseases;microbial;Mission;Modeling;Morbidity - disease rate;mortality;mortality risk;mouse model;Mus;National Heart, Lung, and Blood Institute;novel;Pathogenesis;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Physicians;Population;Publishing;recruit;Regression Analysis;Research;Research Priority;Resources;responsible research conduct;Risk Factors;Role;Science;Scientist;seropositive;skills;Structure of thyroid parafollicular cell;Subgroup;Surface;T memory cell;T-cell receptor repertoire;T-Lymphocyte;Tennessee;Testing;Tissues;Training;Translational Research;United States National Institutes of Health;Virus;Work;X-Ray Computed Tomography

PROJECT_TITLE: Anti-cytomegalovirus Immune Responses in Atherosclerotic Cardiovascular Disease in Persons Living with HIV

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Title: Genetic Studies of Cortex Structure and Development PROJECT NARRATIVE (3 sentences) Dysregulation of cortical development is central to epilepsy, mental deficiency, autism and schizophrenia. Understanding the genetic circuitry controlling the development and function of the cortex is essential to interpret human allele variants in people who have neuropsychiatric disorders. Our results will provide critical information about the genetic control of cortical progenitors and neurons and, once integrated with human genetic information, this will lead to insights into how abnormalities in specific gene networks cause human neuropsychiatric disorders.

PI_NAMEs: RUBENSTEIN, JOHN L. R. (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Alleles;ATAC-seq;autism spectrum disorder;Automobile Driving;Binding;Biological Assay;cell cortex;cell type;Cerebral cortex;ChIP-seq;Chromatin Remodeling Factor;Code;conditional mutant;Development;Diagnosis;disorder risk;Enhancers;epigenomic profiling;epigenomics;Epilepsy;Etiology;gene network;Genes;Genetic;genetic information;Genetic study;Genetic Transcription;genetic variant;Genomics;Hippocampus;Histone H3;Histones;Human;human disease;Human Genetics;in vivo;insight;Lysine;Mental deficiency;Mus;Mutation;Neuronal Differentiation;Neurons;neuropsychiatric disorder;novel;Pattern;Persons;progenitor;promoter;Prosencephalon;Regulation;Regulatory Element;Research;Risk;Role;Schizophrenia;Signal Transduction;spatiotemporal;Specific qualifier value;Structure;subventricular zone;Testing;transcription factor;Transgenic Mice;Transgenic Organisms;transmission process;Untranslated RNA;Ventricular;Work

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: TEMPE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: RELEVANCE  The DNASU Plasmid Materials Repository’s collects or create genes and other DNA-based resources, verifies that they are correct, maintains them safely for long term storage, and distributes them worldwide at low cost to scientific researchers to accelerate research and discovery. Sharing these plasmids will continue to provide tools to develop a better understanding of disease and potential biomarker targets to aid in disease diagnosis and treatment.

PI_NAMEs: LABAER, JOSHUA  (contact);MAGEE, D MITCHELL

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: 11 year old;Academia;Acceleration;analytical tool;Archives;Bacteria;Bar Codes;Bioinformatics;bioinformatics pipeline;Biological;Biological Process;Biomedical Research;Cells;Cloning;Collection;Communities;Complementary DNA;computer infrastructure;computer program;Computer software;cost;Cultured Cells;Custom;Darkness;Data;data handling;Databases;Dedications;Deposition;design;Deterioration;Development;Disease;disease diagnosis;DNA;DNA purification;DNA Sequence;e-commerce;Ensure;Equipment;experience;Explosion;expression cloning;Expression Library;expression vector;Fees;Fees and Charges;flexibility;Functional disorder;Funding;Gene Transfer;Genes;Genetic;Genetic Recombination;Genome;genome sequencing;Glycerol;Government;Growth;Heart;Human;human disease;Human Resources;improved;In Vitro;Individual;Industry;Informatics;Infrastructure;Insecta;interest;Investments;Knowledge;Length;Libraries;Link;member;Methods;Minority;model organism;Modernization;National Institute of General Medical Sciences;next generation sequencing;Ontology;Open Reading Frames;Operating System;operation;Organism;outreach;Pathway interactions;Plasmids;potential biomarker;Price;Process;Production;programs;protein expression;protein function;Protein Structure Initiative;Proteins;Proteome;Protocols documentation;Publications;Reading Frames;Recovery;repository;Research;Research Personnel;Resource Sharing;Resources;Sales;Scientist;Services;Side;Site;social media;software development;software systems;Software Tools;System;targeted biomarker;Time;tool;tool development;Update;user-friendly;vector;Vertebral column;virtual;Visit;web site

PROJECT_TITLE: NIGMS National and Regional Resources - DNASU


NIH_SPENDING_CATS: Cancer;Clinical Research;Prostate Cancer;Urologic Diseases

PHR: CORE C: NARRATIVE The SPORE Biospecimen Pathology Core collects biospecimens and associated clinical and pathologic data on patients who consent to collection. The Core disseminates samples with approval from the Tissue Review and Disbursement Committee and also provides support for SPORE projects through various histologic analyses.

PI_NAMEs: YANG, XIMING J (contact)

PROJECT_TERMS: Archives;Benign;Biological;Biological Assay;Biopsy;Blood;Blood specimen;Cancer Patient;Chicago;Clinical;Clinical Trials;Collection;Consent;Data;Databases;Diagnosis;DNA;Early Diagnosis;Formalin;Freezing;Genomic DNA;Goals;Histologic;Histology;Histopathology;Hospitals;Human;Immune;Immunohistochemistry;Immunophenotyping;improved;innovation;Institutional Review Boards;Lasers;Liquid substance;Malignant - descriptor;Malignant neoplasm of prostate;Microscopy;Mus;Needle biopsy procedure;Paraffin Embedding;Pathologic;Pathology;Patients;Peripheral Blood Mononuclear Cell;Plasma;premalignant;Preparation;prospective;Prostate;Prostate Cancer therapy;Prostatic;Quality Control;Regulation;Research Activity;Research Personnel;RNA;Sampling;Serum;Services;Specimen;Spottings;success;Tissue Embedding;Tissues;Translational Research;Universities;Urine;Whole Blood

PROJECT_TITLE: Biospecimen Core


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: This proposal will support innovative training for graduate students in Neuroscience at Washington University in St. Louis. The Program is known for its depth and breadth of molecular, cellular and systems research on the nervous system and its diseases, integrated into strong mentoring, skill and career development opportunities. This new training grant supports the Neuroscience Program’s efforts to develop students’ key skills in statistical, experimental and quantitative reasoning while they address cutting-edge research questions in the brain sciences.

PI_NAMEs: HOLY, TIMOTHY ;KERSCHENSTEINER, DANIEL  (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TITLE: Neuroscience Training Program at Washington University


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Genetics;Lung;Rare Diseases

PI_NAMEs: REHMAN, JALEES  (contact)

PROJECT_TERMS: Acetyl Coenzyme A;Acute Lung Injury;Adult;Alveolar Macrophages;Anti-Inflammatory Agents;ATP Citrate (pro-S)-Lyase;beta catenin;Binding;Blood Vessels;Cell Line;Cell Nucleus;cell type;Cells;Characteristics;cofactor;Collaborations;Complex;Data;Endothelial Cells;Endothelium;Enzymes;Epigenetic Process;epigenetic regulation;epigenome;G-Protein-Coupled Receptors;Generations;Genetic Transcription;high resolution imaging;Histone Acetylation;Homeostasis;Human;Image;Immune;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Injury;Instruction;interstitial;ITGAM gene;Leucine-Rich Repeat;Licensing;Life;Lipoprotein Receptor;LoxP-flanked allele;Lung;lung injury;Macrophage;Measures;Mediating;Metabolic;Metabolism;metabolomics;migration;Mitochondria;mitochondrial metabolism;Modeling;Modification;monocyte;mouse model;Mus;NADH;optogenetics;Patients;Phenotype;Population;prenatal;Process;programs;Proteins;receptor;Regulation;Resolution;Respiration;response to injury;Role;Signal Transduction;single-cell RNA sequencing;synthetic biology;Testing;tissue injury;tissue repair;Tissues;Transcription Coactivator;Transcriptional Activation;Transcriptional Regulation;transcriptomics;WNT Signaling Pathway

PROJECT_TITLE: Endothelial Instruction of Macrophage Fate in Inflammatory Lung Injury


NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Hematopoietic stem cells (HSCs) are rare cells within human bone marrow that are responsible both for the life-long replenishment of all blood cell lineages and for the curative effects of bone marrow transplantation. The creation of human induced pluripotent cells holds great promise for cellular regeneration therapies, but we cannot currently instruct these cells to specifically generate HSCs in vitro. The overall goal of this application is to determine the molecular cues and behaviors that instruct HSC fate in the vertebrate embryo and from human pluripotent stem cells such that these events may ultimately be replicated routinely to generate patient- specific HSCs for clinical utility.

PI_NAMEs: TRAVER, DAVID ;WILLERT, KARL H (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Anemia;Area;Autoimmunity;Behavior;Binding;Biochemical;Biochemistry;Biological;Biological Models;Biology;Blood;Blood Cells;Bone Marrow;Bone Marrow Transplantation;Cell Differentiation process;Cell Lineage;cell regeneration;Cell Reprogramming;Cell Therapy;Cells;Clinic;Clinical;Cues;Derivation procedure;Development;Developmental Biology;differentiation in vitro;differentiation protocol;directed differentiation;Disease;early embryonic stage;effective therapy;Embryo;Engineering;Epidermal Growth Factor Receptor;Event;experimental study;extracellular;FZD9 gene;Gene Expression Profile;Genetic;Goals;Hematological Disease;Hematopoietic;hematopoietic stem cell emergence;hematopoietic stem cell expansion;hematopoietic stem cell fate;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;hemogenic endothelium;Human;human induced pluripotent stem cells;human pluripotent stem cell;human stem cells;Immune;improved;In Vitro;in vivo;insight;interest;Lateral Mesoderm;Learning;leukemia;Life;Maps;Mediating;Medicine;Methods;Molecular;Molecular Target;Monitor;Motivation;Mus;novel;Outcome;Pathway interactions;Patients;pluripotency;Population;Principal Investigator;Property;Protocols documentation;receptor;reconstitution;regenerative therapy;Reporting;Research;Role;Series;Signal Transduction;single cell sequencing;skills;Somites;Source;Specificity;stem cell biology;Stem Cell Development;stem cell proliferation;Therapeutic;Tissue Engineering;tool;transcriptome;Translating;Transplantation;transplantation therapy;vertebrate embryos;Vertebrates;WNT Signaling Pathway;WNT9A gene;Zebrafish

PROJECT_TITLE: Wnt signaling in hematopoietic development

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Prostate Cancer;Urologic Diseases

PHR: PROJECT 1: NARRATIVE The oncoprotein MYC (c-MYC, N-MYC and L-MYC) is implicated in the majority of human cancer, including prostate cancer. We have generated first-in-class small molecule inhibitors of MYC with in vivo efficacy and tolerability that we plan to develop for the treatment of castration-resistant prostate cancer.

PROJECT_TERMS: Address;androgen independent prostate cancer;Animal Model;Anti-androgen Therapy;Apoptosis;Binding;Biological Assay;c-myc Genes;Castration;Cells;Chemicals;Chromatin;circulating DNA;Clinical;clinical application;cohort;Complex;Coupled;CWR22Rv1;cytotoxicity;Data;Disease;Drug Kinetics;enzalutamide;Gene Amplification;Gene Expression;genetic approach;Genetic Transcription;Goals;Heterodimerization;Human;Impairment;in silico;In Vitro;in vivo;in vivo Model;inhibitor;Lead;leukemia;Link;Malignant neoplasm of prostate;Malignant Neoplasms;Maximum Tolerated Dose;Mediating;Modeling;mouse model;multicatalytic endopeptidase complex;Mus;MYC Family Protein;Neuroendocrine Prostate Cancer;novel;novel therapeutics;Oncogenes;Oncoproteins;overexpression;Pathway interactions;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacodynamic biomarker;pharmacophore;Phase I Clinical Trials;phase I trial;Phosphorylation;Play;pre-clinical;Pre-Clinical Model;pre-Investigational New Drug meeting;preclinical study;Proliferating;prostate cancer cell;prostate cancer cell line;prostate cancer model;Prostate Cancer therapy;protein expression;Recurrence;Regulation;research clinical testing;Resistance;RNA Splicing;Role;Safety;scaffold;Series;small molecule;small molecule inhibitor;small molecule libraries;Specificity;Therapeutic;therapy resistant;Threonine;Toxicology;tumor;tumor growth;Tumor Tissue;Tumorigenicity;Ubiquitin;Up-Regulation

PROJECT_TITLE: Project 1: Targeting the MYC Pathway in Prostate Cancer


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE We create new methods for identifying the alternative structures populated by macromolecules. Direct modeling of multiple conformations aids structure-based drug design and protein engineering.

PI_NAMEs: FRASER, JAMES SOLOMON (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Antibiotic Resistance;Biological;Catalysis;Chemicals;Computer software;Computing Methodologies;Cryoelectron Microscopy;Crystallography;Data;Data Collection;data reuse;Dedications;density;Deposition;design;Development;Disclosure;Drug Design;Engineering;Enzymes;Equilibrium;Glutamate-Ammonia Ligase;Goals;Grant;Heterogeneity;Hydrogen;Image;improved;innovation;interest;Ligand Binding;Ligands;macromolecule;Maps;Methods;Modeling;Modification;Molecular Conformation;Mutation;National Institute of General Medical Sciences;Phosphoric Monoester Hydrolases;Population;Printing;Protein Conformation;Protein Engineering;Proteins;PTPN1 gene;Radiation induced damage;Research;Research Personnel;Roentgen Rays;screening;Signal Transduction;structural biology;Structure;Technology;Temperature;Testing;Validation;web site;Work

PROJECT_TITLE: Discovering and Manipulating Macromolecular Conformational Ensembles

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Asthma;Lung

PROJECT_TERMS: Agreement;Allergic;Allergic Disease;Allergic inflammation;Asthma;Atopic Dermatitis;Award;Budgets;Child;Communication;Communication Programs;Cost Savings;Data Analyses;data integration;Dedications;Disease;Eosinophilic Esophagitis;Epithelial Cells;Epithelium;Expenditure;Funding;Funding Opportunities;Genes;Goals;Infrastructure;Institution;member;Monitor;National Institute of Allergy and Infectious Disease;Notification;Policies;Procedures;programs;Progress Reports;Regulatory Affairs;Reporting;Research;Research Personnel;Resources;Role;Structure;timeline;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Eczema / Atopic Dermatitis;Food Allergies;Genetics;Human Genome;Pediatric

PI_NAMEs: MARTIN, LISA J (contact)

PROJECT_TERMS: Address;Affect;Allergic;Allergic Disease;Allergic inflammation;Allergic rhinitis;Asthma;Atopic Dermatitis;Basic Science;Bioinformatics;Child;Clinical Research;Clinical Sciences;Communities;comorbidity;Coupled;Data;Data Analyses;data integration;data sharing;Development;Disease;Disease remission;Educational workshop;Ensure;Environment;Eosinophilic Esophagitis;Epidemiology;epidemiology study;Epigenetic Process;Epithelial Cells;Epithelium;follow-up;Food Hypersensitivity;Funding;gene network;Genes;Genetic;Genomics;Goals;Heterogeneity;Hypersensitivity;improved outcome;Individual;Inflammation;Infrastructure;insight;Life;Link;Longitudinal cohort;microbiome;Molecular;novel;Organ;Pathogenesis;Pathway interactions;phenotypic data;Physiological;Positioning Attribute;Process;programs;Quantitative Genetics;racial difference;Reproducibility;Research;Research Design;Research Personnel;Resolution;response;Risk Factors;Role;Standardization;statistics;success;Surface;synergism;System;Testing;therapeutic target;Tissues;transcriptomics;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: Data Integration and Analysis Core


NIH_SPENDING_CATS: Asthma;Eczema / Atopic Dermatitis;Food Allergies;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Affect;Age;age effect;Age of Onset;Allergens;Allergic;Allergic Disease;Allergic inflammation;Allergic rhinitis;Asthma;Atopic Dermatitis;Biodiversity;Biological;Biological Factors;Black Populations;Black race;Blood;Cell Degranulation;Child;Childhood Asthma;Clinical;Clinical Data;cohort;comorbidity;Complex;Data;data integration;design;Development;Disease;Disease Progression;Disease remission;Disparity;editorial;Educational workshop;Environmental Risk Factor;Epithelium;filaggrin;Flow Cytometry;Food;Food Hypersensitivity;Gene Expression Profile;Genes;Genetic;genome-wide;health disparity;Heterogeneity;Hypersensitivity;Immune;Immunologics;Immunophenotyping;Laboratories;Length;Life;Literature;Longitudinal cohort;Longitudinal Studies;mast cell;Melanins;Methods;Morbidity - disease rate;mortality;Mutation;Natural History;Organ;Outcome;Participant;Pathogenesis;Pathway interactions;Patient Self-Report;Pattern;peripheral blood;Phenotype;Population;Prevalence;prospective;Proxy;Public Health;Race;racial bias;racial difference;racial population;Research;Resolution;Respiratory Signs and Symptoms;Risk;Risk Factors;Severities;sex;Skin;skin microbiome;social culture;Socioeconomic Factors;socioeconomics;Subgroup;Time;Transcend;transcriptomics;United States National Institutes of Health

PROJECT_TITLE: Refining the Atopic March: Mechanisms of Progression in Black and White Children


NIH_SPENDING_CATS: Asthma;Eczema / Atopic Dermatitis;Food Allergies;Genetics;Lung;Pediatric;Prevention

PI_NAMEs: KOTTYAN, LEAH CLAIRE (contact)

PROJECT_TERMS: Affect;Alleles;Allergic;Allergic inflammation;Allergic rhinitis;Asthma;Atopic Dermatitis;Attenuated;Automobile Driving;biochemical tools;Biological Assay;Black race;candidate identification;Caspase;CCL20 gene;Child;Childhood Asthma;Clinical;cohort;comorbidity;CRISPR/Cas technology;Data;design;Development;Disease;Disease Progression;DNA Methylation;Educational workshop;Emollients;Environmental Exposure;Environmental Risk Factor;Epidemiologic Factors;Epithelium;Family member;filaggrin;Filament;Follow-Up Studies;Food Hypersensitivity;Foundations;Functional disorder;Funding;Future;Gene Expression;Genes;Genetic;genetic variant;genome wide association study;genomic locus;Genotype;Health;Homeostasis;Human;IL8 gene;Immunophenotyping;Individual;Infant;Inflammation;informatics tool;Intervention;Investigation;keratinocyte;Knowledge;Life;Link;loss of function;loss of function mutation;minority subjects;Molecular;mRNA Expression;multiple chronic conditions;Mutation;Other Genetics;Outcome;Patients;Prevalence;prevent;Prevention strategy;progression risk;protein aggregation;protein expression;protein function;Public Health;recruit;Regulation;Reporter;Reporting;Risk;Risk Factors;Role;Signal Transduction;Site;Skin;skin barrier;skin microbiome;Stratum corneum;Structure;synergism;targeted sequencing;Testing;Time;Tissues;United States National Institutes of Health;Variant

PROJECT_TITLE: Filaggrin Expression in Atopic Dermatitis: Regulation and Impact on Disease Progression


PI_NAMEs: ROTHENBERG, MARC E. (contact)

PROJECT_TERMS: Ablation;adaptive immunity;Adult;Agonist;Allergic inflammation;antagonist;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Atopic Dermatitis;Attenuated;Biological;Biological Assay;Calpain;Caspase;CCL26 gene;Cell Differentiation process;Cell Physiology;Cells;Childhood;chromatin immunoprecipitation;Chronic Disease;chronic inflammatory disease;clinically significant;cytokine;Data;Defect;Desmosomes;Diagnostic;Differentiated Gene;Differentiation Antigens;Disease;Eosinophilic Esophagitis;Epithelial Cells;Epithelium;Esophagus;FDA approved;food allergen;Foundations;Functional disorder;gene product;Genes;Genetic Predisposition to Disease;Genetic Transcription;genome-wide analysis;Genomics;Goals;Grant;Immunity;Immunologics;Impairment;improved;Inflammation Mediators;innovation;Interleukin-13;Interleukin-4;Knock-out;Knockout Mice;Link;Maintenance;Mediating;Modeling;Molecular;Morbidity - disease rate;Mus;Nuclear Translocation;Omeprazole;overexpression;Pathogenesis;Pathway interactions;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Production;programs;promoter;Protease Inhibitor;protein expression;Proteins;Proton Pump Inhibitors;Regulation;repaired;Reporter;Repression;Research;response;Role;sensor;Serine;Serine Protease;Skin;Squamous Epithelium;Stimulus;Susceptibility Gene;synergism;Testing;Therapeutic;transcription factor;Transcription Repressor;transcriptome;transcriptome sequencing;translational study;TSLP gene;virtual

PROJECT_TITLE: Role of AHR, OVOL1, and SPINK7 in Eosinophilic Esophagitis


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging;Networking and Information Technology R&D (NITRD)

ORG_CITY: AUSTIN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: 8. Project Narrative The over-arching theme of this program is to train “comprehensive imaging scientists” in the skills necessary to identify clinically relevant problems and develop techniques to improve the prevention, detection, diagnosis, and treatment of human diseases. Trainees learn the full trajectory of medical imaging, including the application of machine learning methods, and emphasis is placed on experiential learning in clinical environments. The global program outcome is for our students to acquire the skill set needed to improve healthcare through imaging science.

PI_NAMEs: MARKEY, MIA K (contact);RYLANDER, HENRY GRADY

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: imaging informatics;imaging science;Training Programs

PROJECT_TITLE: Comprehensive Training program in Imaging Science and Informatics


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Public Health Significance: Over the next four years, the Jackson Heart Study Hypertension Working Group (JHS-HWG) will conduct research to identify approaches to prevent hypertension and improve blood pressure control in African Americans. Also, the JHS-HWG will provide career development opportunities for early stage investigators conducting hypertension research.

PI_NAMEs: LEWIS, CORA E (contact);OGEDEGBE, OLUGBENGA G.;SHIMBO, DAICHI ;SPRUILL, TANYA M

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Accountability;Address;Adult;Africa;African;African American;African American population;Ambulatory Blood Pressure Monitoring;American;American Heart Association;Applications Grants;Area;Award;Behavioral;Black Populations;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;Cardiology;Cardiovascular Diseases;career;career development;Clinic;cohort;college;comparative;Coronary Artery Risk Development in Young Adults Study;Data;Development;Development Plans;Diastolic blood pressure;Disease;Educational workshop;Enrollment;Event;evidence base;Funding;Goals;Grant;Guidelines;hazard;Health;Health behavior;health disparity;Hypertension;hypertension control;hypertension prevention;implementation intervention;improved;Incidence;Infrastructure;innovation;Jackson Heart Study;K-Series Research Career Programs;Knowledge;Leadership;Life Expectancy;Light;Manuscripts;Measurement;Measures;Medicare claim;member;Mentors;Mentorship;minority investigator;National Health and Nutrition Examination Survey;National Heart, Lung, and Blood Institute;next generation;Organ;Paper;Parents;Participant;peer coaching;Peer Group;Peer Review;Phenotype;phenotypic data;Population;Population Research;pre-doctoral;Preparation;prevent;Principal Investigator;Public Health;Publications;Publishing;Questionnaires;Recommendation;Recording of previous events;Research;Research Methodology;Research Personnel;Risk;Role;Sample Size;Science;social health determinants;Statistical Data Interpretation;Time;Training;Training Activity;Underrepresented Minority;United States National Institutes of Health;Visit;Woman;working group;Writing

PROJECT_TITLE: Incorporation of a Hypertension Working Group into the Jackson Heart Study

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Prostate Cancer;Urologic Diseases

PHR: PROJECT 2: NARRATIVE We propose to define the potential patient population with prostate cancer who would likely respond to our novel immunotherapeutic antibody. We also propose to evaluate therapeutic efficacy when combined with frontline standard therapy of mPC in preclinical models. The proposed pre-clinical study will provide rationale for optimal designing of clinical trials. As the antibody is currently under IND-enabling studies, finally, we propose to conduct Phase I clinical trial in mPC patients.

PI_NAMEs: WU, JENNIFER D (contact)

PROJECT_TERMS: androgen independent prostate cancer;Androgen Receptor;Antibodies;Antigen-Antibody Complex;Antigens;Archives;Binding;Biological;bone;Cancer Patient;CD34 gene;CD8-Positive T-Lymphocytes;Cell Physiology;Cell surface;Cells;Characteristics;checkpoint therapy;Circulation;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Colon;Combined Modality Therapy;Data;Disease;Disease Resistance;Dose;Drug Kinetics;Epithelium;Event;first-in-human;Fostering;Future;Genomics;Goals;Granzyme;Hormones;Human;Immune;immune checkpoint blockade;immune clearance;Immune Evasion;Immune system;Immunologic Cytotoxicity;Immunologic Surveillance;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Impairment;improved;inhibitor;Knowledge;Malignant neoplasm of prostate;Mediating;Membrane;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Modeling;Monoclonal Antibodies;Myeloid-derived suppressor cells;Neoplasm Metastasis;nonhuman primate;novel;Oxidative Stress;patient population;Patient Selection;Patients;Pharmacodynamics;Phase;phase 2 study;Phase I Clinical Trials;Population;pre-clinical;Pre-Clinical Model;preclinical study;Prostate;prostate cancer cell;prostate cancer model;Prostatic Neoplasms;receptor;Recommendation;Resistance;resistance mechanism;response;Safety;Sampling;Serum;Signal Transduction;Solid Neoplasm;Stress;Surface;synergism;System;targeted treatment;Testing;Time;Tissue Sample;Toxic effect;Translating;Treatment Efficacy;trial planning;tumor;Tumor Tissue;Tumor-associated macrophages;Vaccines;Variant;Visceral;Visceral metastasis

PROJECT_TITLE: Project 2: Re-directing the Sensitivity of Metastatic Castration-Resistant Prostate Cancer to Immunotherapy


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition;Pediatric

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the intestinal parasitic infection, Giardia lamblia, is a globally distributed intestinal pathogen that causes both acute and chronic infections in humans; for unknown reasons, some people, especially undernourished children, are incapable of clearing Giardia. These children may become sick from Giardia without knowing it -- Giardia seldom causes symptoms, but the parasite independently associates with poor growth and gut dysfunction. Seeking to address the hypothesis that chronic Giardia and Giardia-induced gut damage result from a change in intestinal microbiota as a consequence of low dietary protein intake, this study will identify new pathways of disease following intestinal pathogen infection that could lead to new or improved treatments for impaired gut function.

PI_NAMEs: BARTELT, LUTHER A (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: acute infection;adaptive immunity;Address;Affect;Animal Model;Animals;Antibiotics;Aromatic Amino Acids;Attenuated;Bacteria;bacterial community;bile acid metabolism;Bile Acids;Bile fluid;bile salts;Body Weight decreased;Cellular Immunity;Child;Child Development;Child Health;Chronic;chronic infection;Clinical;clinically relevant;Communities;Complex;Cresol;Data;dehydroxylation;deprivation;Development;Diarrhea;Diet;dietary;Dietary Proteins;Disease;Disease Pathway;enteric infection;enteric pathogen;Environment;Enzymes;Epithelium;Family;Functional disorder;Germ-Free;Giardia;Giardia lamblia;Gnotobiotic;Growth;gut health;gut microbes;gut microbiota;Health;Host Defense;Human;humoral immunity deficiency;Immunity;Immunocompetent;Impairment;improved;Individual;Infection;Inflammation;Injury;innovation;intestinal barrier;Intestinal permeability;Intestines;Lactobacillus;Lamina Propria;Life;Malnutrition;Mediating;Metabolic;Metabolism;metabolomics;Metagenomics;Microbe;microbial;microbial community;microbiota;Modeling;Molecular;mouse model;Mucositis;Mucous Membrane;Mus;normal microbiota;novel;novel marker;Nutrient;nutrition;Oral;Outcome;Parasites;Parasitic infection;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Permeability;permissiveness;Persons;Physiology;Predisposition;prevent;Protein Deficiency;protein intake;Proteins;Proteolysis;prototype;Public Health;Reducing diet;Research;Risk;Role;Secondary to;Small Intestines;Symptoms;synergism;T-Lymphocyte;Testing;Therapeutic;Toxin;Transplantation;Tyrosine;Weaning

PROJECT_TITLE: Interactions of dietary protein intake and intestinal resident microbiota affecting susceptibility to persistent Giardia infection and Giardia mediated enteropathy

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: PROJECT NARRATIVE  The U.S. is facing a serious health crisis of rising rates of maternal mortality and severe morbidity, which are attributable to multiple factors, such as the persistent, deep shortages of maternal care workforce in disadvantaged urban communities and rural areas. The proposed study aims to examine whether recent workforce policy interventions, especially the expansion of National Health Service Corps (NHSC) since 2009, help reduce disparities in maternal care and outcomes between shortage areas and other areas. Our study findings will have important implications for the upcoming implementation of the 2018 Improving Access to Maternity Care Act, the latest NHSC policy change intended to better serve reproductive-age women in shortage areas by further increasing the NHSC supported maternal care providers.

PI_NAMEs: YU, HAO  (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Address;Affect;Affordable Care Act;Age;Age Years;American;Area;Birth;Budgets;care delivery;care providers;Caring;Childbirth;clinical care;cost;Country;County;Data;Data Files;Disadvantaged;Disparity;disparity reduction;Education;Ethnic Population;experience;Funding;Funding Agency;Geographic Locations;Goals;Growth;Gynecologist;Health;health disparity;Health Personnel;health professional shortage areas;Healthcare;Hospital Mortality;Hospitalization;Hospitals;Improve Access;Intervention;Investments;Length of Stay;Literature;Live Birth;Maternal Health;Maternal Mortality;Medically Underserved Area;Methods;Morbidity - disease rate;National Health Service Corps;Nurse Midwives;Outcome;Persons;Policies;Policy Maker;Policy Making;Prenatal care;programs;Provider;Quasi-experiment;racial population;Recovery;recruit;reproductive;rural area;Scholarship;severe maternal morbidity;Students;urban area;Urban Community;Woman;World Health Organization

PROJECT_TITLE: Reducing Maternal Health Disparities: Effects of Recent Health Workforce Policies

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Lung;Pulmonary Fibrosis

ORG_CITY: AMHERST

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Pulmonary fibrosis is a progressive disease that leads to death, but little is known about the mechanism of disease progression. In this project, we propose to develop an engineered lung slice model to study the biomechanical mechanism of differential stretch-induced spatial progression of pulmonary fibrosis. The proposed model will facilitate the research efforts in this important, while poorly examined and traditionally less accessible, area of pulmonary research.

PI_NAMEs: ZHAO, RUOGANG  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;Adenoviruses;Adopted;Affect;Alveolar;Alveolus;animal tissue;Animals;Area;Biomechanics;Bleomycin;Cell Culture Techniques;cell growth;cell injury;Cells;Cessation of life;Complex;Computer Models;cost;Data;design;Development;Devices;Disease;Disease Progression;Engineering;epithelial injury;Evolution;Fibrosis;fibrotic lung;flexibility;Growth;Human;idiopathic pulmonary fibrosis;Image;improved;In Vitro;in vitro Model;in vivo;innovation;Lung;Lung Diseases;Lung fibrogenesis;lung injury;Maps;Mechanics;mechanotransduction;Membrane;Microscopic;Modeling;mouse model;Organ;Pattern;Population;preservation;Profibrotic signal;Progressive Disease;Pulmonary Fibrosis;Pulmonary Pathology;Rattus;reconstitution;Research;Research Personnel;Resolution;Sampling;scaffold;Slice;Spatial Distribution;spatiotemporal;Stretching;Structure;Structure of parenchyma of lung;System;Techniques;Testing;therapy development;Thick;Tissue Engineering;Tissue Model;Tissues;Transforming Growth Factor beta;Vacuum

PROJECT_TITLE: Modeling pulmonary fibrosis progression caused by differential mechanical stretch

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


PHR: DEVELOPMENTAL RESEARCH PROGRAM (DRP): NARRATIVE The SPORE Developmental Research Program provides yearly funding to 4-6 projects that have promising translational potential. It is anticipated that investigators who develop their pilots sufficiently may replace main projects that are not progressing or will secure independent funding in prostate cancer research.

PI_NAMEs: ABDULKADIR, SARKI A. (contact)

PROJECT_TERMS: advanced prostate cancer;anti-cancer research;Area;Chicago;Clinic;Development;Developmental Process;flexibility;Funding;Goals;Health system;innovation;insight;interest;Leadership;Malignant neoplasm of prostate;medical schools;meetings;member;minority investigator;Mission;Monitor;Peer Review;Pilot Projects;Process;programs;Progress Reports;Prostate;recruit;Request for Applications;Research;Research Personnel;Review Committee;Secure;Structure;System;Translating;translational potential;United States National Institutes of Health;Universities;web site;Woman;Writing

PROJECT_TITLE: Developmental Research Program


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: The University of Pennsylvania Innovation In Suicide Prevention Implementation Research (INSPIRE) Center’s overarching goals are: (1) to develop and adapt practice-based and other suicide prevention interventions for minority and disenfranchised groups, and (2) to design and test implementation strategies to optimize how evidence-based practices can be brought to scale efficiently and with high fidelity, for optimal effectiveness. INSPIRE will prioritize strategies that can be deployed rapidly in a range of practice settings, including those with limited resources, thereby increasing their reach and public health impact. Using state-of-the-science methods from participatory research to actively engage stakeholders from many sectors – patients, providers, and payers – and applying innovative, interdisciplinary behavior change and implementation science methods to develop, adapt, and evaluate cost effective interventions, INSPIRE will be poised to be transformational for suicide prevention.

PI_NAMEs: BROWN, GREGORY K (contact);OQUENDO, MARIA A

PROGRAM_OFFICER_NAME: MAVANDADI, SHAHRZAD

PROJECT_TERMS: 15 year old;Accident and Emergency department;Address;Affect;age group;aged;Behavior;behavior change;Black Populations;Caring;Cause of Death;Cognitive Therapy;Collaborations;Community Healthcare;Cost Analysis;cost effective;cost effective intervention;Data;Death Rate;design;disenfranchised population;Disparate;Disparity population;effective intervention;Effectiveness;ethnic minority;evidence base;Evidence based intervention;Evidence based practice;follow-up;Foundations;Funding;General Population;Goals;health care settings;health economics;health information technology;high risk;Hispanic Populations;Home;Homophobia;implementation research;implementation science;implementation strategy;Individual;innovation;interdisciplinary approach;Interdisciplinary Study;Intervention;Intervention Studies;Lesbian Gay Bisexual Transgender;Low income;Machine Learning;Marriage;Mentors;Methodology;Methods;Minority Groups;Modeling;Not Hispanic or Latino;novel;novel strategies;Organizational Culture;Patients;Pennsylvania;perceived discrimination;Persons;Pilot Projects;Policies;Population;Populations at Risk;practice setting;Prevention Research;preventive intervention;Provider;Psychiatry;Psychology;Public Health;racial minority;racism;Recording of previous events;reducing suicide;Research;Research Design;Research Personnel;Resources;Risk;Safety;same-sex marriage;scale up;Scholars Program;Science;Scientist;Services;sex;Sexual and Gender Minorities;suicidal individual;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;telehealth;Testing;Training;Underrepresented Populations;Underserved Population;Universities;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Penn Innovation in Suicide Prevention Implementation Research (INSPIRE) Center


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Suicide;Suicide Prevention

PI_NAMEs: BROWN, GREGORY K (contact)

PROJECT_TERMS: Administrative Efficiency;Advisory Committees;Area;Attention;Award;Biometry;career;career development;Clinic;clinical center;clinical epidemiology;Collaborations;Communication;Communities;community engagement;Consultations;Creativeness;design;Development;Doctor of Philosophy;Ensure;Evaluation;evidence base;experience;Generations;Health;health economics;health information technology;implementation research;implementation science;innovation;interdisciplinary collaboration;Interdisciplinary Study;Knowledge;Lead;Leadership;Link;Logistics;Machine Learning;Manuscripts;Medical;medical schools;meetings;Mentors;Methods;Minority Groups;Monitor;National Institute of Mental Health;Newsletter;novel;Pediatric Hospitals;Philadelphia;Pilot Projects;Policies;Policy Maker;Population;Positioning Attribute;Prevention Research;Prevention strategy;programs;Provider;Psychiatry;Psychology;Research;Research Personnel;Research Project Grants;Resources;Scholars Program;School Nursing;Science;Scientist;Seminal;service coordination;service organization;social media;Strategic Planning;Suicide;Suicide prevention;synergism;tool;Training Programs;Underrepresented Populations;Underserved Population;web site;Work


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer

ORG_CITY: EDWARDSVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: SOUTHERN ILLINOIS UNIV AT EDWARDSVILLE

PHR: According to American Cancer Society, over 1.9 million new cases with approximately 609,360 deaths are expected from cancer in the United States in 2022. Besides, chronic drug treatment may result in development of resistance to the first-line anti-cancer therapies. Our approach to discover newer therapeutics is via targeting the mRNA translation initiation complex, eIF4F that is in feed-forward loop relationship with the oncogenic signaling pathways involved in metastasis and drug resistance.

PI_NAMEs: PATEL, BHARGAV ASHOKBHAI (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: 3-Dimensional;A549;Address;Affinity;American Cancer Society;anti-cancer;Binding;Binding Proteins;Binding Sites;Biological Assay;cancer cell;Cancer cell line;cancer drug resistance;cancer therapy;career;cell growth;Cell Line;Cell Proliferation;Cessation of life;Characteristics;Chemoresistance;Chronic;Clinical Trials;Complex;design;Development;Disease;Docking;Drug Kinetics;Drug resistance;Eukaryotic Initiation Factor-4F;Evaluation;Financial Hardship;Fireflies;Fluorescence Polarization;FRAP1 gene;Funding;Goals;Health;helicase;high throughput screening;Human;In Vitro;inhibitor;Interruption;Luciferases;Malignant Neoplasms;MDA MB 231;Medicine;Messenger RNA;mimicry;mRNA Translation;Neoplasm Metastasis;novel;novel therapeutics;Oncogenic;operation;Outcome Study;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacophore;Pharmacotherapy;Phosphotransferases;PIK3CG gene;Play;Principal Investigator;Process;Prognosis;programs;Property;Protein Biosynthesis;Protein Inhibition;protein protein interaction;Proteins;Proto-Oncogene Proteins c-akt;Publishing;Reaction;Regulation;Renilla;Research;Research Design;Resistance;Resistance development;Ribosomes;Role;scaffold;Scaffolding Protein;Scanning;screening;Signal Pathway;Signal Transduction;small molecule;small molecule inhibitor;Societies;Solubility;Structure;Students;Surface;targeted agent;Testing;Training;trait;Translation Initiation;Translational Repression;Translations;tumor;tumor progression;tumorigenesis;United States;Writing

PROJECT_TITLE: Targeting central regulation of oncogenic signaling through inhibition of translation initiation complex eIF4F


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: CAREER ENHANCEMENT PROGRAM (CEP): PROJECT NARRATIVE The Career Enhancement Program is a critical component of the SPORE in Prostate Cancer, in that it ensures that there will be a continuous influx of talented investigators devoted to prostate cancer research.

PI_NAMEs: CATALONA, WILLIAM J (contact)

PROJECT_TERMS: anti-cancer research;Award;biomedical scientist;career;Chicago;Comprehensive Cancer Center;Credentialing;Department chair;Electronic Mail;Ensure;Epidemiologist;experience;Extramural Activities;Faculty;flexibility;Funding;Future;Grant;Health system;Individual;Institution;interest;Leadership;Length;Letters;Malignant neoplasm of prostate;Medical Oncologist;meetings;member;Mentors;Minority;Molecular;Monitor;Pilot Projects;Process;programs;recruit;Research Personnel;Research Project Grants;Science;Secure;Source;Structure;success;System;Talents;translational cancer research;Underrepresented Populations;Universities;Urologist;web site;Woman;Work

PROJECT_TITLE: Career Enhancement Program


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

PHR: PROJECT NARRATIVE Reductions in white matter microstructure have been implicated as a central feature of Alzheimer’s disease (AD); yet, the molecular drivers of white matter alterations are unknown. The goal of this project is to perform rigorous evaluation of the genetic and molecular pathways of medial temporal lobe white matter microstructure that contributes to accelerated cognitive decline in AD. Such work will serve as a catalyst for the identification of novel therapeutic targets for neurodegenerative disease.

PI_NAMEs: ARCHER, DEREK B (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Academic Medical Centers;Acceleration;Accounting;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease risk;Architecture;Area;Atrophic;Automobile Driving;Award;Axonal Transport;Baltimore;Big Data Methods;biobank;Biological;Brain;Candidate Disease Gene;career;career development;Career Mobility;catalyst;Clinical;Cognitive;cohort;Complex;computing resources;Data;Data Analyses;data harmonization;Data Set;Dedications;Diffusion Magnetic Resonance Imaging;Ensure;Environment;Evaluation;Extracellular Space;Foundations;Functional disorder;Funding;Future;Gene Expression;Genes;Genetic;genetic analysis;genetic architecture;Genetic Diseases;Genetic study;Genetic Techniques;genetic variant;genome resource;genome wide association study;genome-wide;genome-wide analysis;Genomics;Goals;gray matter;hippocampal atrophy;Image;imaging genetics;Impaired cognition;in vivo;Laboratories;large scale data;Lead;life span;Longitudinal cohort;Longitudinal Studies;Measurement;medial temporal lobe;Mediating;Memory;Mentors;Minority;Modeling;Molecular;multidisciplinary;myelination;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;neuroinflammation;new therapeutic target;novel;Oligodendroglia;Participant;Pathway Analysis;Pathway interactions;polygenic risk score;Positioning Attribute;pre-clinical;Process;professor;Registries;religious order study;Research;research and development;research study;Resolution;Resources;risk variant;Role;Senile Plaques;Signal Transduction;skills;Structure;tau aggregation;Techniques;Technology;Testing;Tissues;tractography;Training;trait;Validation;Variant;Water;white matter;white matter damage;Wisconsin;Work

PROJECT_TITLE: Genetic Contributors to White Matter Microstructure in Aging and Alzheimers Disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Cardiovascular;Neurosciences

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: We will define mechanisms for regional formation of aneurysms in the aorta, a deadly disease with no therapies. We will focus on a neurotransmitter produced by fat surrounding the aorta. This novel target may provide a therapeutic target for aneurysmal disease.

PI_NAMEs: CASSIS, LISA A (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Abdomen;abdominal aorta;abdominal fat;Adipocytes;Anatomy;Aneurysm;Angiotensin II;antagonist;Aorta;aortic arch;Aortitis;Area;Brown Fat;Calcium;Catabolism;Cations;Cd68;Chest;Complement;Dangerousness;Data;Deamination;Development;differential expression;Diffuse;Disease;Elements;Environmental Risk Factor;Enzymes;Exposure to;Fatty acid glycerol esters;Functional disorder;Genetic;Human;Hydrogen Peroxide;In Vitro;in vivo;Inflammasome;Inflammation;Infusion procedures;Ion Channel Gating;Left;Length;Ligands;Link;Lipopolysaccharides;Macrophage;male;Mediating;Mitochondria;mitochondrial dysfunction;Modeling;Monoamine Oxidase;Mus;Mutant Strains Mice;Myelogenous;Necrosis Induction;nerve supply;neural;Neurons;Neurotransmitters;new therapeutic target;novel;Peripheral;Production;Protein Isoforms;Reactive Oxygen Species;receptor;recruit;regional difference;Regulation;Reporting;Respiration;Risk;Role;Rupture;Serotonergic System;Serotonin;sex;Sex Chromosomes;Side;Source;Stimulus;therapeutic target;Thermogenesis;Thoracic aorta;Tropisetron;Tryptophan;Tryptophan 5-monooxygenase;Tunica Adventitia;uptake;Vascular Diseases

PROJECT_TITLE: The serotonergic system in periaortic fat regulates regional aortopathy development

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Human Genome;Precision Medicine

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: PROJECT NARRATIVE We will use our model system to characterize the genetic mechanisms that underlie seasonal rhythms, including genes and molecular pathways that are conserved across animals. Since many human diseases exhibit seasonal rhythms but cannot be examined at the same molecular level as our model, our project will generate results that can be used to enhance human health. We will also use our model to shed light on the molecular and evolutionary processes that generate individual- and population-level patterns in human disease risk and are being used in personalized medicine to diagnose and treat human illness.

PI_NAMEs: DELMORE, KIRA  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Admixture;admixture mapping;Animal Model;Animals;Area;Behavior;Behavioral;Behavioral Genetics;Biological Models;Brain region;comparative;Conflict (Psychology);Diagnosis;Disease;disorder risk;Evolution;Exhibits;fitness;Gene Expression Regulation;Genes;Genetic;Genetic Recombination;Genetic study;genetic variant;Genetic Variation;Genome;genomic locus;Genomics;Health;Human;human disease;Hybrids;Individual;Infrastructure;innovation;insight;Knowledge;Laboratories;Link;Mediating;member;migration;Modeling;Molecular;novel strategies;Pathway interactions;Pattern;personalized medicine;Phenotype;phenotypic data;pleiotropism;Population;Process;reproductive;Research;Role;Seasons;Shapes;Songbirds;Source;System;Taxonomy;Testing;Tissues;trait;Variant;Work

PROJECT_TITLE: When genomes collide: using hybrid zones to transform our understanding of behavioral and speciation genetics.

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_CITY: CLEMSON

ORG_DEPT: GENETICS

ORG_NAME: CLEMSON UNIVERSITY

PHR: HEALTH RELEVANCE The world’s population is rapidly growing older, with a concomitant decrease in physical function of older individuals. Pharmacological inhibition of the angiotensin-converting enzyme (ACE) is an effective therapy in improving age-related impairment of physical function and is a potential strategy to slow human aging, but there is variation in improvement of physical performance following ACE inhibition that is likely due to genetic variation. This research will identify novel genes, pathways, and mechanisms that contribute to the beneficial effects of angiotensin- converting enzyme inhibitor therapy on age-related decline in physical mobility, one of the most debilitating effects of aging.

PI_NAMEs: ANHOLT, ROBERT R. H;DE LUCA, MARIA ;MACKAY, TRUDY F. (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Address;Affect;Age;age difference;age effect;age related;age related decline;age-related disease;Aging;Angiotensin-Converting Enzyme Inhibitors;Angiotensins;Animal Model;anti aging;Area;Binding;Bioenergetics;Biological;Biological Models;Biology;Blood flow;blood pressure medication;Blood Vessels;Candidate Disease Gene;candidate selection;Cardiovascular system;Categories;Cell Physiology;Chest;coisogenic;Data;design;differential expression;Drosophila genus;Drosophila melanogaster;drug action;effective therapy;Enzyme Inhibition;Enzyme Inhibitor Drugs;Enzymes;extend lifespan;Failure;Female;fly;gene conservation;Gene Expression;Genes;Genetic;Genetic study;Genetic Variation;genome resource;genome wide association study;genome-wide;genomic biomarker;genomic predictors;Genotype;Goals;hallmarks of aging;Health;Health Status;healthspan;healthy aging;hemodynamics;Homologous Gene;Human;Hypertension;improved;in vivo;Individual;Individual Differences;inhibitor therapy;insight;Intervention;Intervention Studies;Invertebrates;knock-down;life span;Lisinopril;Locomotion;Longevity;male;Maps;Mediating;Metabolic Pathway;Metabolism;metabolome;Mitochondria;Mobility decline;Modeling;Morphology;Motor Activity;mouse model;Muscle;Muscle Mitochondria;novel;Older Population;Ontology;Organ;Pathway interactions;Peptidyl-Dipeptidase A;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Physical Function;physical impairment;Physical Performance;Play;Population;preservation;Publishing;Regulatory Pathway;Renin-Angiotensin System;Research;response;RNA Interference;Role;senescence;Signal Pathway;Skeletal Muscle;System;Testing;Tissues;trait;transcriptome;Variant;Vertebrates;Walking;Work

PROJECT_TITLE: Genetic Basis of Lifespan and Healthspan Extension by ACE Inhibition in Drosophila

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Dissemination and Implementation Research;Machine Learning and Artificial Intelligence;Mental Health;Patient Safety;Prevention;Suicide;Suicide Prevention

PI_NAMEs: MANDELL, DAVID S (contact)

PROJECT_TERMS: Address;Adherence;Administrator;base;behavioral health;Businesses;Clinical Trials Data Monitoring Committees;Communication;Communities;cost;Cost Analysis;cost effective;Data Analyses;data harmonization;data management;Data Pooling;data sharing;design;Discipline;Economics;Effectiveness;Ensure;Ethics;Evaluation;evidence base;Goals;human subject protection;implementation cost;implementation framework;implementation measures;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Incubators;Industry;innovation;Institutional Review Boards;Intervention;Lead;Machine Learning;Measurement;Measures;meetings;member;Mental Health;Methodology;Methods;Modeling;Natural Language Processing;novel;Output;Patient Self-Report;Pennsylvania;Pilot Projects;Population;Prevention Research;preventive intervention;Process;Productivity;prototype;Qualitative Research;Quantitative Evaluations;Reporting;Research;Research Design;Research Personnel;Research Project Grants;research to practice;Resources;Safety;safety assessment;scale up;Science;stakeholder perspectives;Standardization;statistics;Suicide;Suicide prevention;System;Testing;Time;Time and Motion Studies;tool;Universities;uptake;web site

PROJECT_TITLE: Methods Core


ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Millions of people in the U.S. and worldwide have been diagnosed with Parkinson’s disease, a progressively debilitating disorder characterized by abnormal movement function. The goal of this study is to identify the specific changes in neuronal activity and connectivity between cortical and subcortical brain regions that are associated with the onset and progression of individual motor abnormalities associated with Parkinson’s disease. The results of this study will provide the understanding necessary for the refinement of current and development of future therapies, e.g. deep brain stimulation, transcranial magnetic and electrical stimulation and gene therapy, directed at modulating the neuronal activity in the basal ganglia-thalamocortical circuit responsible for the development of parkinsonian motor symptoms.

PI_NAMEs: JOHNSON, LUKE AARON;VITEK, JERROLD L (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine;Animals;Anterior;Area;Basal Ganglia;Bradykinesia;Brain region;Cells;Characteristics;Coupling;Data;Deep Brain Stimulation;design;Development;Diagnosis;Disease;Dopamine;Dorsal;Drug-Induced Dyskinesia;Dyskinetic syndrome;Electric Stimulation;Evolution;Frequencies;Functional disorder;Funding;Future;Gait;Gait abnormality;gene therapy;Globus Pallidus;Goals;improved;Individual;L-DOPA induced dyskinesia;Levodopa;Modeling;Motor;Motor Cortex;motor disorder;motor symptom;Movement;MPTP model;MPTP non-human primate;Neurons;neurophysiology;neuroregulation;Nodal;nonhuman primate;Parkinson Disease;Parkinsonian Disorders;Pattern;Peripheral Nerve Stimulation;Persons;Physiological;Population;Prefrontal Cortex;Preparation;receptive field;response;Rest;Role;Sensory;sensory cortex;Severities;Site;somatosensory;Somatosensory Cortex;Structure;Structure of subthalamic nucleus;targeted treatment;Thalamic structure;therapy development;Transcranial magnetic stimulation;Work

PROJECT_TITLE: Neurophysiological Mechanisms Underlying Parkinsonian Motor Signs

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Genetics

PHR: Project Narrative Ribosomes are essential molecular machines required in all cells to make proteins, and different cell types produce different numbers of ribosomes to suit their varying needs. Tight control over ribosome production is essential for normal tissue function, but our understanding of the regulatory proteins that exert this control is limited. This proposal seeks to identify key proteins that control ribosome production in different cell types in mammals, and understand their roles in maintaining normal tissue development and health.

PI_NAMEs: PARALKAR, VIKRAM R. (contact)

PROJECT_TERMS: Binding;Biogenesis;Biological Models;Biology;cell type;Cells;Chromatin;Complex;Development;Disease;DNA Binding;Energy consumption;Epigenetic Process;Eukaryota;Functional disorder;genetic regulatory protein;Genetic Transcription;Goals;Health;Homeostasis;Human;In Vitro;in vivo;Knowledge;Malignant Neoplasms;Mammals;Maps;Molecular Machines;mouse model;Mus;Mutation;Normal Cell;Normal tissue morphology;novel;Organ;Organism;Process;Production;Proteins;Proteomics;Regulation;Reporting;Ribosomal DNA;Ribosomal RNA;Ribosomes;ribosomopathy;RNA;Role;Tissues;transcription factor;Work

PROJECT_TITLE: Regulation of rRNA transcription in mammalian tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Eye Disease and Disorders of Vision;Heart Disease;Neurosciences;Prevention;Stroke

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Strokes caused by blood clots coming from the heart are the most feared types of stroke and cause a high rate of death and disability. Central retinal artery occlusion (CRAO) is a type of ischemic stroke affecting the back of the eye whose mechanisms are poorly understood. The objective of this study is to clarify the relationship between disorders causing clotting in the heart and CRAO and, in doing so, identify a new group of patients who are vulnerable to future, preventable strokes from the heart.

PI_NAMEs: MAC GRORY, BRIAN  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Academic Medical Centers;Acute;Address;Affect;Age;Anticoagulation;Applied Research;Area;Atrial Fibrillation;Attenuated;Awareness;Back;beneficiary;Biological Markers;Biometry;Blood coagulation;Blood Vessels;Brain imaging;Cardiac;Cardiac Electrophysiologic Techniques;Cardiology;cardiovascular risk factor;career;Carotid Atherosclerotic Disease;Carotid Stenosis;Central Retinal Artery Occlusion;Cerebrovascular Disorders;Cerebrum;Clinic;Clinical Investigator;Clinical Research;Coagulation Process;cohort;Collaborations;comorbidity;Comparative Effectiveness Research;Cross-Sectional Studies;Data;Data Science;Data Set;Databases;Death Rate;Development;Diagnosis;Diagnostic;Diameter;disability;Disease;Electrocardiogram;Embolism;Etiology;evidence base;Eye;Failure;Fright;Functional disorder;Future;Goals;Heart;Heart Atrium;Heart Diseases;heart rhythm;Incidence;indexing;insight;Institution;Internal Carotid Artery Stenosis;Investigation;Ipsilateral;Ischemic Stroke;K-Series Research Career Programs;Knowledge;Left;Life;Link;Medicare;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Monitor;multidisciplinary;Neurology;novel;Observation in research;Observational Study;Ophthalmology;Pathogenesis;Pathology;Pathway interactions;patient oriented;patient subsets;Patients;Persons;Pharmacy facility;Physicians;Physiological;Play;Population;population based;prevent;Prevention strategy;prospective;Publications;Recurrence;Research;Research Design;Research Personnel;Retina;Risk;Risk Factors;risk mitigation;Role;Sampling;Scientist;Secondary Prevention;Sentinel;Serum;sex;skills;Societies;Stenosis;Stroke;Structure;Testing;Therapeutic Embolization;Thrombus;Time;Training;Ultrasonography;Ventricular;Ventricular Dysfunction;Visual disability;Walking

PROJECT_TITLE: Cardioembolism as a Mechanism of Central Retinal Artery Occlusion


NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative With new HIV infections in the US stalled at about 40,000 per year, the US government has laid out an ambitious plan, End the HIV Epidemic (EHE), which aims to reduce new HIV infections by 90% over ten years. We propose to expand the Cost-effectiveness of Preventing AIDS Complications (CEPAC) computer simulation model, to determine the cost-effectiveness of biomedical interventions, including pre-exposure prophylaxis (PrEP), strategies to engage patients along the full continuum of HIV care, and novel ART regimens. We will then use optimization modeling to identify the best combination of biomedical and implementation approaches, in different settings and populations, to achieve the goals of the End the HIV Epidemic Initiative.

PI_NAMEs: FREEDBERG, KENNETH ALAN (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;antiretroviral therapy;California;care costs;Caring;Clinical;Collaborations;Complex;Computer Simulation;Computers;Continuity of Patient Care;cost;cost effective;cost effectiveness;Cost Savings;County;design;Detection;Diagnosis;disorder prevention;Disparity;Early Diagnosis;Early treatment;economic disparity;economic impact;effective therapy;Effectiveness of Interventions;emtricitabine;Epidemic;evidence base;experience;Fumarates;geographic disparity;Goals;Guidelines;Health;Health system;high risk;HIV;HIV diagnosis;HIV Infections;HIV therapy;Human immunodeficiency virus test;improved;Incidence;Infection;Injectable;International;Intervention;Investments;Laboratories;Lamivudine;Los Angeles;mathematical model;Mathematical Model Simulation;Mathematics;Methods;Modeling;models and simulation;Monitor;neutralizing antibody;next generation;NIH Office of AIDS Research;novel;Outcome;patient engagement;Persons;Pharmaceutical Preparations;Population;pre-exposure prophylaxis;prevent;Prevention;programs;Public Health;racial disparity;Regimen;Research;Research Personnel;Research Priority;Resource Allocation;Resources;Risk;Services;simulation;State Government;Strategic Planning;Tenofovir;Treatment Protocols;United States;United States Dept. of Health and Human Services;Use Effectiveness;Work

PROJECT_TITLE: Cost-Effectiveness of Preventing HIV Complications

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Serious Mental Illness

PHR: PROJECT NARRATIVE: PUBLIC HEALTH RELEVANCE Given the prevalence and the personal, social, and economic burden of major depressive disorder, it is imperative to develop a more comprehensive understanding of the brain in this condition. This innovative research program will yield important advances for the neural conceptualization of depression that is based on person-specific brain organization. Addressing this important but underexplored issue promises to ultimately contribute to the development of brain-based treatments in psychiatry and thus improved interventions, not only for major depression, but also for other mental illnesses.

PI_NAMEs: SACCHET, MATTHEW D (contact)

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TERMS: Address;Affect;Affective;Aftercare;Agreement;Amygdaloid structure;Anhedonia;antagonist;anti-depressive agents;Anxiety;anxiety spectrum disorders;anxious;Architecture;Arousal;Behavior;Behavioral;behavioral outcome;behavioral response;biosignature;Brain;brain based;Brain Mapping;Bupropion;burden of illness;Cardiology;Clinical;clinical care;Clinical Trials;cognitive control;Cognitive deficits;comorbidity;Complex;Corpus striatum structure;Data;Data Set;data sharing;Databases;Development;Diagnosis;Diagnostic;Disease;Disease remission;Dopamine Uptake Inhibitors;Economic Burden;Exhibits;Foundations;Functional Magnetic Resonance Imaging;Future;Goals;Hippocampus;improved;Individual;Individual Differences;individual variation;innovation;Intervention;kappa opioid receptors;Lateral;Link;Machine Learning;Major Depressive Disorder;Maps;Medial;Medical;Mental Depression;Mental disorders;Methodology;Methods;Moods;neural;neural model;Neuroanatomy;neuroimaging;Norepinephrine;Oncology;organizational structure;Outcome;Parietal Lobe;Patients;Pattern;Performance;Persons;Pharmacology;Pharmacotherapy;precision medicine;predicting response;Prediction of Response to Therapy;Prefrontal Cortex;Prevalence;programs;Psychiatry;public health relevance;Recurrence;Research;response;Selective Serotonin Reuptake Inhibitor;Sertraline;social;Stress;Symptoms;Syndrome;System;Testing;theories;Translations;Treatment outcome;treatment response

PROJECT_TITLE: Individualized brain systems and depression


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Lung

PHR: Narrative: The proposed training program at the University of Texas at Austin is an inter-professional education partnership between the Schools of Social Work and Medicine. The proposed program aims to recruit and retain promising pre- and postdoctoral scholars from underrepresented groups to train and engage them in behavioral, population, and implementation science research to promote health equity in heart and lung diseases. Key innovations include recruitment and mentoring activities firmly grounded in the reality that cultural and racial/ethnic diversity in the scientific workforce is critical to the production of innovative scientific knowledge, a team-based mentoring approach with a near-peer mentoring component, and cross-fertilization of social work and medical trainees.

PI_NAMEs: CASTRO, YESSENIA ;CUBBIN, CATHERINE  (contact);MATSUI, ELIZABETH C.

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Cardiovascular Diseases;diversity and equity;health equity;Lung Diseases;Research Training;Scientist

PROJECT_TITLE: Research Training to Promote Scientist Diversity & Health Equity in Cardiovascular & Lung Disease