NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Depression;Disability Research;Hearing Loss;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Prevention;Rehabilitation

ORG_CITY: MADISON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The purpose of the proposed project is to characterize how hearing-related behavior in daily life underlies the association between hearing loss and poor social-emotional health outcomes and whether hearing aid use can moderate this association. The proposed research is relevant to public health because it will determine how and to what extent audiologic intervention can moderate the risks of depression, loneliness, and isolation following hearing loss. Findings from this study will provide evidence for the role of audiology in quality of life improvement, lay groundwork for new clinical practices to maximize intervention benefits in daily life, and demonstrate new ways to conceptualize and measure intervention outcomes.

PI_NAMEs: JORGENSEN, ERIK JORGEN (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acoustics;Address;Adult;Affect;age-related disease;American;Audiology;Auditory;Award;Behavior;behavior change;Classification;Clinic;Clinical;clinical practice;Communication;Conceptions;Ecological momentary assessment;Effectiveness;Effectiveness of Interventions;Emotional;Environment;Epidemic;Evidence based practice;Future;Goals;Health;Hearing;Hearing Aids;hearing impairment;hearing loss treatment;improved;Individual;Intervention;Length;Life;Life Style;Loneliness;Machine Learning;machine learning classification;Measures;Mental Depression;Methods;Modeling;National Institute on Deafness and Other Communication Disorders;novel;Outcome;Outcome Measure;Participant;patient engagement;Persons;Public Health;Quality of life;Research;Risk;Risk Reduction;Role;social;Social isolation;sound;Speech;speech in noise;Standardization;Strategic Planning;Surveys;Technology;Time;Work

PROJECT_TITLE: Hearing-related behavior and its relationship to hearing aid use and social-emotional health outcomes


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: EMERGENCY MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The University of Michigan (UM) proposes the continuation of a UM Regional Coordinating Stroke Center (RCC) as part of Stroke Net. The RCC will facilitate enrollments in stroke-related clinical trials within both the University of Michigan and its affiliated sites. The RCC will also provide research experiences and career enhancement opportunities to early-stage investigators and will continue to propose stroke clinical trials.

PI_NAMEs: BROWN, DEVIN L;SCOTT, PHILLIP  (contact)

PROGRAM_OFFICER_NAME: MCCARTHY, SEAN PATRICK

PROJECT_TERMS: Accident and Emergency department;acute stroke;Adult;Advisory Committees;Agreement;Applied Research;Area;Basic Science;Biological Markers;biomarker development;care systems;career;Cause of Death;Childhood stroke;Clinical;Clinical Research;Clinical Sciences;clinical trial enrollment;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Clinical Trials Support Unit;Collaborations;Conduct Clinical Trials;data quality;Dedications;design;Development;disability;Eligibility Determination;Emergency Care;Emergency Medicine;Enrollment;Ethnic Origin;experience;Faculty;Fellowship Program;Foundations;Funding;Geographic Locations;Glacier;Goals;Health;Home;Hospitals;Informed Consent;Infrastructure;innovation;International;investigator training;Lead;Leadership;Mentorship;Michigan;Mission;multidisciplinary;National Institute of Neurological Disorders and Stroke;Neurological emergencies;Neurology;neurosurgery;patient population;Patients;pediatric emergency;Phase;Phase III Clinical Trials;Population;Prevention;programs;protocol development;Public Health Schools;Recording of previous events;Records;Recovery;recruit;Rehabilitation therapy;Research;Research Personnel;Research Training;Resources;Scholars Program;Site;Sleep;Speed;Stroke;stroke clinical trials;stroke intervention;stroke patient;Stroke prevention;stroke trials;StrokeNet clinical trials;success;synergism;System;Testing;Thrombectomy;Training;Training and Education;Training Programs;treatment trial;trial design;Underrepresented Minority;United States National Institutes of Health;Universities;Wood material;working group

PROJECT_TITLE: University of Michigan Regional Coordinating Stroke Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (17)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative This K24 Mid-Career Investigator Award seeks support for Dr. Cosgrove, professor of psychiatry at Yale and Co-Director of the Translational Alcohol Research Program (TARP), an NIAAA-funded T32 for postdoctoral fellows and residents; training and mentorship activities supported by this award will take place in the context of a project on the Yale-Specialized Center of Research Excellence (SCORE) that is focused on investigating sex differences in the neurochemistry and treatment for alcohol use disorder (AUD). The K24 award will support Dr. Cosgrove in her career development with training in the areas of alcohol-related metabolomics, alcohol-induced liver disease, and mentorship skills, with a focus on diversity, equity and inclusion, with the goal of providing mentorship to a diverse group of mentees with a wide range of alcohol interests.

PI_NAMEs: COSGROVE, KELLY P. (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Achievement;alcohol abuse therapy;alcohol measurement;alcohol research;alcohol use disorder;Alcoholic liver damage;Alcoholic Liver Diseases;Alcohols;Area;Award;Biological;biomarker identification;Body System;Brain;Brain imaging;career;career development;Cells;Centers of Research Excellence;Clinical;Clinical Treatment;Cognition;Collection;course development;Data;Data Collection;Data Set;density;Development;Development Plans;Doctor of Philosophy;drinking;Equilibrium;equity, diversity, and inclusion;Faculty;Fostering;Functional disorder;Funding;Goals;graduate student;Grant;imaging biomarker;Imaging Techniques;Immune;improved;Individual;interest;K-Series Research Career Programs;kappa opioid receptors;Knowledge;Liver;Maintenance;Manuscripts;Measures;meetings;men;Mentors;Mentorship;metabolome;metabolomics;Microglia;Mid-Career Clinical Scientist Award (K24);Moods;National Institute on Alcohol Abuse and Alcoholism;negative affect;Nerve Degeneration;neurochemistry;Neurocognitive;Neurosciences;new therapeutic target;Participant;patient oriented;patient oriented research;Persons;Plasma;Positioning Attribute;Positron-Emission Tomography;Postdoctoral Fellow;professor;programs;Psychiatry;Recording of previous events;Recovery;recruit;Research;Research Design;Research Ethics;Research Personnel;Research Project Grants;Sampling;Scientist;sex;Sex Differences;skills;Specialized Center;Stress;stress reactivity;student mentoring;Synapses;System;Techniques;Training;Treatment outcome;undergraduate student;Woman;Work;Writing

PROJECT_TITLE: Mentoring in the Clinical Neuroscience of Alcohol Use Disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Physical Rehabilitation;Rare Diseases;Rehabilitation;Scleroderma;Telehealth

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: Project Narrative The purpose of this proposed study is to prepare for a multisite randomized controlled trial that will examine the efficacy of a telerehab intervention to improve upper extremity function in patients with systemic sclerosis. We will establish our multisite research team, develop our study procedures and regulatory documents, and train our occupational therapists who will assess outcomes and provide the intervention for the trial. This planning period will allow us to develop a robust U01 grant application to test the efficacy of telerehab which will provide an important step in knowledge of how to provide treatment for patients with rare disease.

PI_NAMEs: KHANNA, DINESH ;MURPHY, SUSAN L. (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Acceleration;acceptability and feasibility;Affect;Applications Grants;arm;arm function;Autoimmune;Blood Vessels;Caring;Chronic;Client satisfaction;clinical practice;clinical trial protocol;Clinical Trials;Collaborations;Communities;community clinic;Comparison arm;Complication;Conduct Clinical Trials;Connective Tissue Diseases;Contracture;COVID-19 pandemic;Cutaneous;Data;data management;design;Development Plans;Diffuse;disability;Disease;Early Intervention;Education;Effectiveness;efficacy evaluation;efficacy testing;efficacy trial;Equity;evidence base;experience;Foundations;functional improvement;functional loss;Geography;Goals;Hand;Health Services Accessibility;Health system;high risk;implementation barriers;implementation intervention;improved;Institutional Review Boards;Intervention;Intervention Trial;joint mobilization;Joints;Knowledge;Lupus;Manuals;medical specialties;Methods;mobile application;Modeling;Monitor;Movement;Multi-Institutional Clinical Trial;multi-site trial;Occupational Therapist;Occupational Therapy;operation;Outcome Assessment;Pain;Patient Care;Patients;Persons;Pharmacological Treatment;physically handicapped;pilot test;Population;practice setting;Preparation;prevent;Procedures;Process;programs;Protocols documentation;Provider;Quality of life;randomized, clinical trials;Randomized, Controlled Trials;rare condition;Rare Diseases;Recommendation;recruit;rehabilitation service;Rehabilitation therapy;remote delivery;Reporting;Research;Research Personnel;Rheumatoid Arthritis;Running;Safety;Scleroderma;Self Management;Services;Severity of illness;Site;Skin;Specialist;Structure;symptom management;System;Systemic Scleroderma;telehealth;telerehabilitation;Testing;Therapeutic Intervention;Training;Translations;Travel;Upper Extremity;Work

PROJECT_TITLE: Planning for a Multisite Efficacy Trial of Upper Extremity Telerehabilitation for Systemic Sclerosis

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Ciliopathies are complex genetic disorders that can exhibit severe birth defects due to abnormalities in the formation or function of the cilium. A large number of proteins are thought to be involved in the cilium, but in only a few of these do we know the molecular pathways in which they function and whether they are associated with disease (ciliopathies). In this proposal, we take advantage of the explosion of genomic information from patients with rare developmental disorders and recent advances in identifying genes associated with the cilium to identify novel ciliopathies in rare and undiagnosed disease repositories, generate precision engineered mouse models corresponding to these patients, define the molecular and cellular pathways responsible for their birth defects, and generate data that can be used to predict therapeutic strategies through CPAM's drug discovery pipeline.

PI_NAMEs: YODER, BRADLEY K. (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Affect;Animal Model;Animals;Automobile Driving;Biochemistry;Bioinformatics;bioinformatics tool;Biology;Body System;candidate identification;Cellular biology;Cilia;ciliopathy;cilium biogenesis;cilium motility;Classification;Clinical;Communities;Complex;Computational Biology;Congenital Abnormality;Congenital cerebellar hypoplasia;congenital heart abnormality;craniofacial;CRISPR/Cas technology;Cystic kidney;Data;data repository;Data Science;Data Set;Defect;Development;developmental disease;Diagnosis;Diagnostic;diagnostic tool;Disease;disease diagnostic;drug discovery;Dysplasia;early pregnancy;Engineering;Erinaceidae;Evaluation;Exhibits;Explosion;FRAP1 gene;Functional disorder;G-Protein-Coupled Receptors;Generations;Genes;Genetic;Genetic Diseases;genetic testing;genetic variant;Genomics;Goals;Health;Human Development;Hydrocephalus;Hypogonadism;improved;indexing;Individual;International;Knockout Mice;Late pregnancy;Liver;Machine Learning;Maintenance;malformation;Medicine;meetings;Methods;Microcephaly;Modeling;Molecular;molecular diagnostics;Morphology;mouse model;mutant;Mutant Strains Mice;Neural Tube Closure;Neural Tube Defects;notch protein;novel;null mutation;Outcome;Pancreas;Pathogenicity;Pathway Analysis;Pathway interactions;Patients;Phenotype;Platelet-Derived Growth Factor;Positioning Attribute;Pregnancy;Process;protein expression;protein transport;Proteins;Proteome;Protocols documentation;Publications;Rapid screening;Rare Diseases;Regulation;repository;response;Retinal Diseases;Role;Sensory;Severities;Signal Pathway;Signal Transduction;Situs Inversus;skeletal;Source;Structural Congenital Anomalies;Structure;Symptoms;Syndrome;Testing;Therapeutic;tool;trafficking;transcriptome sequencing;Translating;Variant;variant of interest;variant of unknown significance;Work;Xenopus;Zebrafish

PROJECT_TITLE: Mechanisms of ciliopathy associated structural birth defects

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Cannabinoid Research;Chronic Pain;Digestive Diseases;Endocannabinoid System Research;Inflammatory Bowel Disease;Neurosciences;Pain Research;Social Determinants of Health;Therapeutic Cannabinoid Research;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE (RELEVANCE) Abdominal pain is driven, in part, by alterations to the sensitivity of sensory neurons that innervate the intestine. The proposed studies investigate how glial cells interact with sensory neurons to influence abdominal pain and how these interactions are influenced by sex, inflammation, and early life adversity. Understanding these fundamental mechanisms that regulate gut sensory function will lead to new therapies to treat abdominal pain in irritable bowel syndrome and inflammatory bowel disease.

PI_NAMEs: GULBRANSEN, BRIAN D. (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Abdominal Pain;Ablation;Acute;Adverse event;afferent nerve;Afferent Neurons;Animal Model;Biological Assay;Calcium;Cell Communication;Cells;cellular imaging;Chronic;Colitis;Colon;Communication;Data;Development;Disproportionately impacts women;early experience;early life adversity;early life stress;effective therapy;Endocannabinoids;Enteral;Event;Exhibits;experience;experimental study;Female;Funding;Gastroenteritis;gastrointestinal;Genes;Genetic;Goals;Histamine;Histamine N-Methyltransferase;Hypersensitivity;Image;imaging study;Immune;improved;In Vitro;in vivo;Inflammation;Inflammatory Bowel Diseases;insight;Intestines;Irritable Bowel Syndrome;Knowledge;Label;Life;Life Experience;male;maternal separation;Measurement;Measures;Modeling;Monoacylglycerol Lipases;Mus;Neonatal;Nerve;Nerve Fibers;Neuroglia;neurotransmission;Nociception;Nociceptors;novel;novel therapeutics;Pain;Pain management;Peripheral;Physiological;Predisposition;Proteins;response;Risk Factors;RNA;Sensory;sex;Sex Differences;sexual dimorphism;Signal Transduction;Stress;Testing;therapeutic development;Tissues;Transgenic Animals;Transgenic Mice;Transgenic Organisms;Visceral;Visceral pain;Whole Organism

PROJECT_TITLE: Enteric glia and visceral pain

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Our gut microbial symbionts contribute to our overall metabolism, impacting physiological processes and disease susceptibility. The proposed studies aim to further explore how gut microbes, through nutritional inputs like a high protein diet, generate a specific metabolite that impacts heart physiology, and susceptibility for development of heart failure.

PI_NAMEs: HAZEN, STANLEY L (contact)

PROGRAM_OFFICER_NAME: SHANBHAG, SUJATA MADHUKAR

PROJECT_TERMS: Acute;Adrenergic beta-Antagonists;Adrenergic Receptor;Animal Disease Models;Animal Model;Awareness;beta-adrenergic receptor;Biological Markers;Cardiac Myocytes;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular disorder risk;Catecholamines;Cells;Chronic;Clinical;clinical prognostic;Clinical Research;Companions;Complement;Complex;Data;design;Development;Diet;dietary;dietary constituent;Dietary Proteins;Disease;disease model;Disease susceptibility;EFRAC;Endowment;Engineering;Enzymes;Etiology;fecal transplantation;Fibrosis;Functional disorder;Functional impairment;Gene Expression;Generations;Genetic;genetic approach;Germ-Free;Gnotobiotic;Goals;gut microbes;gut microbiome;gut microbiota;Health;Heart;Heart Diseases;Heart failure;heart failure with reduced ejection fraction;heart function;Homeostasis;Human;Impairment;in vivo;Inflammatory;Infusion procedures;Intake;Investigation;Knock-out;Knockout Mice;Knowledge;Left;Link;Longterm Follow-up;Macronutrients Nutrition;Manuscripts;Mediating;Metabolic;Metabolism;metabolomics;Microbe;microbial;microbial community;microbiota metabolites;Modeling;mouse model;multidisciplinary;Mus;Myocardial;novel;Nutrient;Nutritional;Observational Study;Organism;Pathogenesis;Pathway interactions;Patient risk;Patients;pharmacologic;Phenotype;Phenylalanine;Phenylalanine Metabolism Pathway;Physiological;Physiological Processes;Physiology;Plasma;pre-clinical;Predisposition;preservation;Prevention;Production;Prognosis;prognostic value;protein expression;Proteins;Publishing;Receptor Signaling;response;Risk;Risk Factors;Role;Signal Pathway;Signal Transduction;Structure;Study models;symbiont;System;Testing;therapeutic target;Thrombosis;thrombotic;Tissues;trait;Transforming Growth Factor beta;Transplantation;trimethyloxamine;Ventricular;Ventricular Remodeling

PROJECT_TITLE: Gut microbial dietary phenylalanine metabolism and heart failure

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Data Science;Digestive Diseases;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Pancreatic Cancer;Precision Medicine;Prevention;Rare Diseases;Skin Cancer

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE The RAS gene family encodes the central components of the RAS signaling pathway, which is the most frequently altered oncogenic pathway across all cancers but is especially prominent in pancreatic, colorectal, lung, and skin malignancies. These RAS-driven cancers collectively account for the largest single source of cancer-related mortality in the United States but are often treatable if intercepted at an early stage, meaning that new strategies are desperately needed to anticipate and prevent RAS-driven cancers. In this proposal, I outline an interdisciplinary research project grounded in my 12 years of experience in genomic data science to systematically discover new inherited genetic factors that influence the onset, progression, and dynamics of RAS-driven cancer, which has the potential to uncover previously unknown facets of cancer biology, enable preventative screening tailored to an individual’s inherited genetic risk, improve equity in clinical oncology, and nominate new targets for the prevention or treatment of these devastating malignancies.

PI_NAMEs: COLLINS, RYAN LEWIS (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Age of Onset;Biology;Cancer Biology;cancer diagnosis;Cancer Etiology;cancer genome;cancer initiation;cancer risk;Cancer Science;cancer type;career;Cell model;Cessation of life;Chromosome Mapping;Clinical;clinical care;Clinical Data;Clinical Oncology;Code;cohort;Collection;Colorectal;Colorectal Adenocarcinoma;Colorectal Neoplasms;computer framework;Dana-Farber Cancer Institute;Data;data integration;Data Science;Data Set;design;Detection;Disease;Early Intervention;Ecosystem;Ensure;Environment;Equity;Event;Evolution;Exhibits;experience;Foundations;Frequencies;gain of function;Gene Expression;Genetic;genetic architecture;genetic association;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genetic study;genetic variant;genome sciences;genome sequencing;genome-wide;genomic data;genomic variation;Genomics;Germ Lines;Germ-Line Mutation;Goals;Heritability;high risk population;human genomics;improved;Individual;Inherited;Intercept;Interdisciplinary Study;Knowledge;KRAS2 gene;Laboratories;lifetime risk;Lung;Lung Adenocarcinoma;Lung Neoplasms;Malignant Neoplasms;Medical Oncology;Melanoma;Mentors;Mentorship;Methods;Modernization;mortality;Motivation;mouse model;mutant;Mutation;mutational status;neoplastic cell;new therapeutic target;Nucleotides;Oncogenic;Oncology;Outcome;Pancreas;Pancreatic Adenocarcinoma;pancreatic neoplasm;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Population;Population Heterogeneity;post-doctoral training;Postdoctoral Fellow;precision oncology;prevent;Prevention;Preventive screening;Productivity;Prognosis;programs;rare variant;RAS driven cancer;RAS driven tumor;RAS Family Gene;RAS genes;ras Oncogene;Ras Signaling Pathway;Research;Research Project Grants;Resources;Risk;Risk Factors;Role;screening;Screening for cancer;skills;Skin Malignancy;Skin Neoplasms;Somatic Mutation;Source;Statistical Models;statistics;targeted treatment;Technical Expertise;Testing;therapeutic development;Training;transcriptomics;treatment response;tumor;tumor progression;Tumor Subtype;United States;Untranslated RNA;Variant;virtual;Work

PROJECT_TITLE: Dissecting the Role of Germline Genetics in RAS-Driven Cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (O1)]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE We plan to conduct an effectiveness trial to evaluate the benefits and barriers to hybrid closed loop (HCL) pump therapy in underserved adults with type 1 diabetes, and to apply the learnings to develop an implementation toolkit to support broader adoption of HCL in underserved communities.

PI_NAMEs: WEISSBERG-BENCHELL, JILL ;WOLPERT, HOWARD A (contact)

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: Address;Adoption;Adult;Algorithms;arm;Automation;Behavioral;Bionics;Black Populations;Body Weight;Boston;Clinic;Clinical;clinical decision-making;clinical practice;Collaborations;Continuous Glucose Monitor;cost;Data;Decision Aid;Development;Devices;diabetes management;Diabetes Mellitus;diabetes self-management;Diabetic Ketoacidosis;Disparity;Ecological momentary assessment;Educational workshop;effectiveness evaluation;effectiveness study;effectiveness trial;efficacy trial;Eligibility Determination;emerging adult;ethnic minority;Evaluation;Event;expectation;experience;follow-up;Funding;Glucose;hands-on learning;health equity;Healthcare;high risk population;Hispanic Populations;hospitalization rates;Hybrids;Hypoglycemia;improved;Individual;individual patient;Injection of therapeutic agent;Injections;instrument;Insulin;Insulin-Dependent Diabetes Mellitus;Insurance;Insurance Coverage;International;Interview;Lead;Life;Lived experience;Low income;Medicaid;Medical center;Methodology;Methods;Minority Groups;Modernization;mortality;multidisciplinary;Not Hispanic or Latino;novel;operation;Pancreas;Patient Education;patient population;Patient Preferences;Patient Selection;Patients;Perception;Persons;preference;primary outcome;programs;Psychologist;psychosocial;public health insurance;Pump;Qualifying;racial minority;Randomized;randomized effectiveness trial;recruit;Research;Research Personnel;Risk;Risk Factors;Role;Running;Safety;safety net;Scientist;secondary outcome;shared decision making;shift work;social;stressor;Structure;support tools;Surveys;System;Technology;Time;tool;Training;Translations;underserved community;Underserved Population;United States National Institutes of Health;user centered design;Weight Gain

PROJECT_TITLE: Effectiveness Trial to Support Adoption of Hybrid Closed Loop Therapy in Underserved Adults with Type 1 Diabetes: Impact of System Functionality and Features on Lived Experience

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-M (O1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PUBLIC HEALTH NARRATIVE Most smokers are interested in quitting, more than half attempt to quit each year, and nearly all relapse within a year, largely due to difficulty managing cravings, which is a prominent symptom of withdrawal. Cigarette craving has been a target for smoking cessation treatments, however, these treatments have yielded low abstinence rates thereby prompting calls for novel treatment approaches to reduce cigarette cravings. Based on compelling laboratory data, utilization of olfactory stimuli represent a novel approach to improve smoking cessation and mitigate cigarette cravings; thus, this study will: 1) build upon basic, laboratory research to refine and evaluate the effect of a novel olfactory stimulation delivery system on cigarette cravings in vivo during a smoking cessation attempt, and 2) determine whether an olfactory stimulation delivery system can increase successful smoking cessation when paired with an established smartphone-based smoking cessation intervention.

PI_NAMEs: BUSINELLE, MICHAEL S.;GAREY, LORRA  (contact);SAYETTE, MICHAEL ANDREW

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Abstinence;Address;Adult;Age;Attenuated;Basic Science;Behavioral Research;biobehavior;cancer health disparity;Cellular Phone;Cessation of life;cigarette craving;cigarette smoking;Clinical;Clinical Trials;Cognition;craving;Crossover Design;Data;design;digital delivery;direct application;disability;Discipline;Disparity;Ecological momentary assessment;Emotional;Emotions;Environment;feasibility testing;flexibility;follow up assessment;follow-up;Frequencies;Future;Gel;General Population;Generations;Goals;Guidelines;improved;in vivo;innovation;interest;Intervention;Interview;Knowledge;Laboratories;Laboratory Research;Link;Low income;Malignant Neoplasms;Mental disorders;Methodology;Methods;mHealth;MMP11 gene;Monitor;Motivation;Nature;neurobehavioral;Neurobiology;Nicotine Dependence;nicotine patch;novel;novel strategies;Odors;Olfactory Pathways;olfactory stimulus;Outcome;Participant;Patient Self-Report;Phase;population based;portability;Prevalence;preventable death;Protocols documentation;Public Health;Publishing;racial minority;Randomized;Randomized, Controlled Trials;recruit;Relapse;Reporting;Research;Research Design;seal;sex;smartphone application;Smell Perception;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking intervention;Smoking treatment;Specific qualifier value;successful intervention;Surveys;System;Telephone;Testing;theories;Translating;Underserved Population;United States;Withdrawal Symptom;Work

PROJECT_TITLE: An Innovative Digitally-Delivered Olfactory Method for Reducing Cigarette Cravings and Supporting Smoking Cessation

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-9 (O1)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Brain Disorders;Endocrine Disruptors;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention

ORG_DEPT: NEUROLOGY

PHR: Project Narrative Parkinson’s disease (PD) is a systemic neurologic disorder and proteinopathy, influenced by the dysfunction of autophagy lysosomal pathways resulting in the accumulation of aggregated protein and neurodegeneration. Chlorinated solvents, such as trichloroethylene (TCE), are pervasive air and water contaminants and are linked to PD risk epidemiologically. This proposal investigates how inhalation of TCE impairs lysosomal function, in part by activation of LRRK2, uncovering novel mechanisms for PD risk from environmental solvent exposure.

PI_NAMEs: DE MIRANDA, BRIANA  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Acceleration;Adult;aging related disease;air contaminant;alpha synuclein;Autophagocytosis;Brain;brain tissue;Chronic;Corpus striatum structure;Data;Degradation Pathway;Dementia;design;Development;Disease;disorder prevention;disorder risk;dopaminergic neuron;Dose;Enteral;Environment;Environmental Exposure;Environmental Health;Environmental Pollutants;Environmental Pollution;Environmental Risk Factor;epidemiologic data;Epidemiology;Etiology;Experimental Models;exposed human population;Exposure to;Female;Functional disorder;Funding;Genetic Risk;genetic risk factor;Homeostasis;Human;Immunohistochemistry;Impaired cognition;Impairment;improved;In Vitro;in vivo;Individual;Industrialization;Inhalation;Inherited;Injections;Lewy Bodies;Link;Location;LRRK2 gene;Lysosomes;male;Measures;Mediating;Membrane;Metals;Midbrain structure;Modeling;Modification;Morphology;Motility;motor disorder;Movement Disorders;Mus;National Institute of Environmental Health Sciences;Nerve Degeneration;Nervous System Disorder;neuron loss;Neurons;neuropathology;neurotoxicity;novel;novel strategies;Oral;Organic solvent product;Outcome;Outcome Assessment;Oxidative Stress;Parkinson Disease;Parkinsonian Disorders;Pathogenicity;Pathology;Pathway interactions;Patients;Peripheral;Pesticides;pharmacologic;Phosphorylation;Phosphotransferases;Play;pre-formed fibril;prevent;Process;protein aggregation;Protein Degradation Inhibition;Protein Kinase;Proteins;Proteolysis;proteostasis;proteostasis loss;Rattus;Research;response;Risk;risk variant;Rodent;Role;sensor;Severities;Signal Transduction;Solvents;sporadic Parkinson's Disease;Strategic Planning;Structure;synucleinopathy;System;Testing;Time;Tissues;Toxic effect;Toxic Environmental Substances;toxicant;Transgenic Mice;Trichloroethylene;Volatilization;Water Pollutants;Work

PROJECT_TITLE: The role of lysosomal impairment in trichloroethylene induced Parkinsonian neurodegeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 ARL-S (R1)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Sensory deprivation in one modality results in adaptive reorganization in the spared modalities, a phenomenon known as crossmodal plasticity. This proposal seeks to identify, for the first time, when crossmodal functional changes emerges during early development and the underlying neural circuit rearrangement. Results from the proposed experiments will provide a clear template to guide investigation of early crossmodal changes in other sensory pathways (e.g., somatosensory), will accentuate the impact of well-balanced ambient sensory environment in sensory development and will shed light on novel therapeutic interventions for the recovery of function of deprived senses in infants with sensory disorders, e.g., congenital hearing impairment.

PI_NAMEs: MUKHERJEE, DIDHITI  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Adult;Age;Auditory;Auditory area;auditory deprivation;awake;Axon;Bilateral;Birth;Brain;Calcium;Cells;Child;Clinical;Compensation;congenital hearing loss;critical period;deprivation;Development;Ear;Electrophysiology (science);Environment;experience;experimental study;External auditory canal;extracellular;Eye;Genetic;Image;Impairment;In Vitro;in vivo;in vivo calcium imaging;Infant;Investigation;Lasers;Literature;Modality;Mus;Neonatal;nerve supply;Nervous System;neural circuit;Neural Pathways;neuronal circuitry;Neurons;Newborn Infant;novel therapeutic intervention;patch clamp;Pathway interactions;Patients;Peripheral;placebo group;postnatal;pup;Recovery of Function;response;Retina;Scanning;Sensory;sensory cortex;Sensory Deprivation;Sensory Disorders;Shapes;Slice;somatosensory;sound;Stimulus;Testing;Thalamic structure;Time;transmission process;two-photon;Visual Cortex;visual deprivation

PROJECT_TITLE: Crossmodal plasticity in the auditory cortex in the precritical period

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cardiovascular

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative: The University of Houston Cardiovascular Undergraduate Research Experience (UH-CURE) will engage underrepresented minority undergraduate students in hands-on heart, blood, and lung research. Students will also participate in educational and professional development activities that will inspire and prepare students to succeed in biomedical research careers.

PI_NAMEs: MCCONNELL, BRADLEY K (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Asian Americans;Attention;Awareness;Biomedical Research;Blood;Cardiovascular system;career;cohort;Collaborations;college;Communication;cultural competence;Cultural Sensitivity;Data;Data Analyses;Development;Development Plans;Disadvantaged;diversity and equity;Education;Education Projects;education research;education resources;Educational process of instructing;Enrollment;Evaluation;experience;experimental study;Exposure to;faculty mentor;Fellowship;Foundations;Future;Goals;graduate school;graduate student;Health;Heart;Hispanic Populations;Hispanic-serving Institution;Human Resources;Individual;innovation;insight;Institution;Instruction;interest;International;Laboratory Research;Learning;Lung;Measures;Mental Health;Mentors;Mission;National Heart, Lung, and Blood Institute;Native Americans;news;next generation;Pacific Island Americans;Participant;pedagogy;Population Heterogeneity;Productivity;Program Evaluation;programs;Qualifying;Recording of previous events;Reporting;Research;Research Personnel;Research Training;Resources;Scientist;skills;Students;success;summer program;Surveys;symposium;Training;Training and Education;Training Programs;Transferable Skills;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;Universities;Well in self;Writing

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-K (O1)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Estrogen;Women's Health Research

ORG_CITY: DAYTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WRIGHT STATE UNIVERSITY

PHR: Project Narrative There is urgent need to identify new therapeutic targets for treating advanced ER+ breast cancer (BC) with endocrine therapy (ET) resistance and/or metastasis. Based on our important findings we postulate that FBXL16, a poorly-studied F-Box protein, promotes ER+ BC development, metastasis and ET resistance by upregulating the stability and expression levels of ERα (both wild type and the ligand-binding domain (LBD) activating mutants) and co-activator SRC-3 and thus the oncogenic ERα signaling. If proven true, our study would advance our understanding of the mechanisms underlying ET resistance and metastasis of ER+ BC, and would provide a rationale to develop novel therapy against FBXL16 for treating advanced ER+ BC, in particular those driven by ERα with LBD activating mutations.

PI_NAMEs: LONG, WEIWEN  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: advanced breast cancer;Advanced Malignant Neoplasm;Aromatase Inhibitors;Biological Assay;Breast Cancer Cell;Breast Cancer Patient;Cancer Cell Growth;Cell Line;cell motility;Cells;Clinic;Cultured Cells;Development;Drug resistance;Drug Targeting;Endocrine;ESR1 gene;Estrogen Receptors;Estrogens;Experimental Models;F-Box Proteins;FDA approved;Fulvestrant;Gene Expression;Goals;Growth;hormone therapy;Hormones;Immunoprecipitation;In Vitro;in vivo;innovation;Letrozole;Ligand Binding Domain;Malignant Breast Neoplasm;Mammary gland;Mammary Neoplasms;MCF7 cell;Mediating;Metastatic breast cancer;Metastatic Neoplasm to Lymph Nodes;Molecular;Mouse Mammary Tumor Virus;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Mutation;NCOA3 gene;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutics;Oncogenic;overexpression;Patients;Pharmaceutical Preparations;Play;Prognostic Marker;protein protein interaction;Proteins;Proteomics;Relapse;Resistance;response;Role;Selective Estrogen Receptor Modulators;Signal Transduction;small hairpin RNA;T47D;Tamoxifen;Testing;Therapeutic;therapy resistant;Transgenic Organisms;tumor;tumor growth;tumor progression;tumor xenograft;ubiquitin-protein ligase;Ubiquitination;Up-Regulation;Western Blotting;Xenograft procedure

PROJECT_TITLE: FBXL16 as a novel factor in promoting endocrine therapy resistance and metastasis of ER+ breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Q (81)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Data Science;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Lung;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Exposure to wildfire smoke is known to adversely impact the pulmonary system, though there remains an overall lack of knowledge surrounding the mechanisms and health risks across this highly variable exposure landscape of wildfire smoke, particularly within the expanding Wildland Urban Interface (WUI). This grant is designed to leverage the experimental strengths across in vitro, in vivo animal, and human systems to provide data needed for the health risk assessment of complex wildfire smoke mixtures. Findings will yield populations that are at heightened risks for health effects of wildfire smoke inhalation exposures based upon nearby fuel sources, and data will be used to effectively quantify these risks across difficult to study exposure scenarios that now require health guidances.

PI_NAMEs: RAGER, JULIA  (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Address;Animals;anthropogenesis;Area;Asthma;Atmosphere;Benchmarking;Big Data;Biological;Biology;Biomass;biomass fuel;biomass smoke;Bronchitis;Bronchoalveolar Lavage Fluid;Burn injury;Cell Death;Cell Hypoxia;Cells;Cellular Stress;Characteristics;Chemicals;Chronic Obstructive Pulmonary Disease;climate change;Complex;computational toxicology;Computer Models;Data;Data Science;demographics;design;Disease;disorder prevention;Dose;Dyspnea;Elements;Encapsulated;Environment;Environmental Health;Ethics;Evaluation;exposed human population;Exposure to;extracellular vesicles;Feasibility Studies;Female;forest;Foundations;Future;Genetic Transcription;Goals;Grant;Health;Histopathology;Human;human study;Human Subject Research;Human Volunteers;Hypoxia;hypoxia inducible factor 1;improved;In Vitro;in vivo;Incidence;Individual;Inflammation;Inhalation;Inhalation Exposure;Injury;innovation;Institution;Knowledge;Laboratories;Lung;male;Measures;Mediation;meetings;Metals;Methods;Modeling;Molecular;Molecular Profiling;multiple omics;Mus;National Institute of Environmental Health Sciences;novel;Outcome;particle;Pathway interactions;Plastics;Population;Prevalence;Protein Analysis;protein biomarkers;Proteins;Proteomics;Public Health;public health relevance;pulmonary function;Research;Respiratory Tract Infections;response;Risk;Risk Assessment;Risk Estimate;risk prediction;Sampling;Severities;Signal Transduction;Smoke;smoke inhalation;Solid;Source;Sputum;stem;Stress;success;System;Testing;tissue injury;tool;Toxic effect;Toxicology;transcriptomic profiling;transcriptomics;Translations;volunteer;Wildfire;Wood material;Work

PROJECT_TITLE: Wildland Urban Interface Exposure Toxicity in Cells, Animals, and Humans


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Rural Health;Stroke

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative The Stroke Net Regional Coordinating Center-University of Pittsburgh (STN-UP) will continue to leverage the regional dominance of UPMC in healthcare, the CTSI, existing clinical research collaborations at the University of Pittsburgh and other institutional resources for its successful clinical trials infrastructure. The STN-UP will continue practices that have led to successful trial recruitment and regional research network administration, while adopting new measures to further increase efficiency and capacity for entering patients into trials with equitable representation of women and minorities, and contribute to the educational, collaborative, and administrative functions of the National Clinical Coordinating Center (NCC), the National Data Management Center (NDMC) and the overall network. The combined efforts of NIH Stroke Net and STN-UP will ensure that diverse patients have access to impactful stroke trials and maintain specialized training for clinician researchers.

PI_NAMEs: NOGUEIRA, RAUL GOMES;ROCHA, MARCELO  (contact)

PROJECT_TERMS: Acute;Admission activity;Adopted;Adult;Advisory Committees;Agreement;Ambulatory Care Facilities;Applications Grants;Area;career;career development;Catchment Area;cerebrovascular;Childhood;Childhood stroke;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Network;Collaborations;collaborative approach;Communities;Community Hospitals;Consultations;Data Coordinating Center;Dedications;Development;Discipline;Doctor of Philosophy;Education;education research;Emergency Care;Enrollment;Ensure;Equity;Ethnic Population;Evaluation;experience;Faculty;faculty research;Fellowship;Fostering;Funding;Geographic Locations;Health;Healthcare;Hospitals;improved;Industry;Infrastructure;innovation;insight;Institution;Institutional Review Boards;Maryland;Measures;Medical center;meetings;Mentors;Minority;Minority Groups;Minority Health Research;Minority Recruitment;National Institute of Neurological Disorders and Stroke;Neurology;Neurosciences;next generation;outreach;Participant;participant enrollment;participant retention;Patient Recruitments;Patients;Pennsylvania;Performance;performance site;Physicians;Population;Presbyterian Church;Prevention;programs;Publications;Qualifying;racial population;Randomized;Recovery;recruit;Rehabilitation therapy;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;retention rate;Rotation;Rural;rural area;Satellite Centers;skills;Stroke;Stroke prevention;stroke trials;StrokeNet trials;Structure;suburb;success;Support Groups;Telemedicine;Time;Training;Translational Research;trial planning;trustworthiness;underserved area;United States National Institutes of Health;Universities;Update;Woman;working group

PROJECT_TITLE: NIH StrokeNet Regional Coordinating Center - University of Pittsburgh (STN-UP)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: HARTFORD

ORG_NAME: HARTFORD HOSPITAL

PHR: PROJECT NARRATIVE Metabolic and bariatric surgery (MBS) is the most effective treatment for severe obesity; however, many patients experience significant weight regain that undermines improvements in physical and mental health. MBS patients are advised to engage in regular PA to prevent significant weight regain, but most do not, and interventions do not address patients' low internal drive to be regularly active. This study tests an Acceptance and Commitment Therapy-based intervention designed to motivate bariatric patients to make sustainable changes in physical activity to prevent significant weight regain.

PI_NAMEs: BOND, DALE S (contact);LILLIS, JASON

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Adherence;Adult;adult obesity;Affect;bariatric surgery;Bariatrics;Behavior;Behavioral;Body mass index;Body Weight;Body Weight decreased;Clinical;clinical practice;comorbidity;Complication;COVID-19;Data;Education;Educational workshop;effective intervention;effective therapy;Electronic Mail;Emotions;exercise intervention;experience;Feedback;follow-up;Future;Generations;Goals;Guidelines;Health;Health behavior;Health behavior change;Health Promotion;high risk;Hour;Impairment;improved;Intervention;Learning;Life Expectancy;Life Style Modification;Link;Maintenance;Measures;Mediator;Mental Health;Metabolic;Monitor;Morbid Obesity;Morbidity - disease rate;mortality;Motivation;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity treatment;Operative Surgical Procedures;Outcome;Participant;Patients;Performance;Persons;Pharmaceutical Preparations;Physical activity;physical conditioning;physical impairment;Physical therapy;pilot test;Postoperative Period;prevent;Prevention;primary outcome;Procedures;Psyche structure;psychosocial;Quality of life;Randomized;randomized trial;Reporting;Risk;secondary outcome;success;symposium;targeted treatment;Telephone;Testing;theories;therapy design;Thinking;Time;Touch sensation;treatment effect;United States;Videoconferencing;vigorous intensity;Weight;weight loss intervention

PROJECT_TITLE: Using Acceptance and Commitment Therapy to Promote Autonomous Motivation for Increased Physical Activity and Improved Weight Loss Maintenance in Bariatric Surgery Patients: A Randomized Trial

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Pediatric

ORG_CITY: ASHLAND

ORG_DEPT: BIOLOGY

ORG_NAME: ASHLAND UNIVERSITY

PHR: PROJECT NARRATIVE This project will use the zebrafish as a cost-efficient model system to characterize the roles that novel genes play in regulating eye lens development. The proposed experiments will address open questions about how lens cells lose their nuclei and organelles to produce the transparency of the lens and prevent cataract, while also adding to our general understanding of how cells remodel themselves in diverse tissues. Undergraduate college students at Ashland University will gain valuable experience using innovative genome manipulation, molecular biology, bioinformatic and cell visualization techniques while conducting these studies.

PI_NAMEs: POSNER, MASON  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Address;Animals;Anterior;Autophagocytosis;Binding;Bioinformatics;biological adaptation to stress;Biological Models;Blindness;Blood Cells;cancer cell;Cardiomyopathies;Cataract;Cell Differentiation process;Cell Nucleus;cell type;Cells;Cellular Structures;Communities;cost efficient;CRISPR screen;CRISPR/Cas technology;Crystalline Lens;Defect;Development;Developmental Biology;differential expression;Epithelial Cells;Erythroid Cells;Excision;experience;experimental study;Eye;fiber cell;Fishes;Funding;gene discovery;Gene Expression;Gene Expression Regulation;gene function;Gene Proteins;Genes;Genetic;Genetic Transcription;Genome;Guide RNA;Image;innovation;insight;Knock-out;Laboratories;Larva;Learning;lens;Lens development;Lens Fiber;lens transparency;Life;Location;loss of function;Malignant Neoplasms;Mammals;Messenger RNA;Metabolic;Mitochondria;mitochondrial autophagy;Mitosis;Modeling;Modernization;Modification;Molecular;Molecular Biology;mRNA Expression;Mus;Muscle;mutant;Mutate;novel;Nuclear;Organelles;Organism;Penetrance;Phenotype;Play;Post-Transcriptional Regulation;prevent;Process;Proteins;proteostasis;Regulation;Research;RNA-Binding Proteins;Role;screening;Signal Transduction;Signaling Molecule;Study models;System;Techniques;Testing;Tissue Differentiation;Tissues;Training;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Translations;undergraduate student;Universities;university student;Visualization;Work;Zebrafish;zygote

PROJECT_TITLE: Identification and characterization of genes regulating zebrafish lens development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-R (86)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: NEWARK

ORG_DEPT: CHEMISTRY

ORG_NAME: NEW JERSEY INSTITUTE OF TECHNOLOGY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The high spatial and temporal resolution of light makes optical regulation using the light-responsive group an appealing approach for cellular events controlling, which has broad applications in cell biology, neurobiology, and biomedicine. Due to the fundamentally importance of light-responsive groups and the shortage of tools with effective red-to-near infrared sensitivity, we will try to develop an efficient system using rigidified structures based on weak covalent bond, and apply them in drug delivery for cancer treatment. Given the wide usage of these optical tools in basic science and biomedical application, these techniques would allow timed delivery of targeted bioactive molecules in deep tissue.

PI_NAMEs: ZHANG, YUANWEI  (contact)

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: absorption;Address;Area;Basic Science;Biological;Biological Assay;biological research;Biological Sciences;Biology;Boron;cancer therapy;Cell Culture Techniques;Cellular biology;cellular imaging;Chemical Structure;Chemistry;chromophore;Complex;covalent bond;design;Development;Dissociation;Drug Delivery Systems;Environment;Event;Evolution;Exhibits;experience;Experimental Designs;experimental study;Extinction;Family;Fluorescence;Frequencies;Funding;gene therapy;Harvest;improved;In Vitro;in vivo;interest;Ions;irradiation;Kinetics;Knowledge;Lanthanoid Series Elements;Light;Malignant Neoplasms;materials science;Modification;Molecular;Monitor;multidisciplinary;nanoparticle;Neurobiology;Neurons;novel;Opsin;Optics;organic base;Organic Synthesis;Penetration;Photons;Phytochrome;precision drugs;Preparation;Process;Prodrugs;programs;Property;Reaction;Regulation;Research;Research Personnel;Resolution;Sampling;scaffold;Scientist;Signaling Molecule;spatiotemporal;Spectrum Analysis;Structure;Surface;System;targeted delivery;Techniques;temporal measurement;Time;Tissues;tool;Toxic effect;Training;Translations;tumor;two-photon;undergraduate student;United States National Institutes of Health;water solubility;Work

PROJECT_TITLE: Efficient red-to-NIR photo-uncaging and applications in therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (80)]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Congenital Structural Anomalies;Data Science;Dental, Oral, and Craniofacial Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Velopharyngeal (VP) anomalies, often associated with cleft palate and other craniofacial conditions, can have a substantial impact on speech and communication abilities as well as overall quality of life if unsuccessfully repaired. This investigation will provide the foundation for a successful line of focused, translational research to improve clinical assessments and speech outcomes in children born with VP anomalies as well as reduce the need for subsequent revision surgeries by developing a method for automated, pre-operative, objective, patient- specific anatomic assessment. The results of this proposal will directly contribute to NIDCD’s mission to improve the health of children with speech and resonance disorders associated with velopharyngeal dysfunction by enabling a high impact collaboration between speech physiology, craniofacial/plastic surgery, data science, and biomedical engineering, particularly in the area of precision medicine, to improve speech and surgical outcomes for children with cleft/craniofacial conditions.

PI_NAMEs: MASON, KAZLIN  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: 3-Dimensional;Acceleration;Age;Air;Algorithms;analytical method;Anatomy;Area;Artificial Intelligence;automated algorithm;automated analysis;Biomedical Engineering;Bone Tissue;care burden;Child;Child Health;Childhood;Cleft Palate;Clinical;Clinical assessments;clinical care;clinical decision-making;clinical development;clinical practice;clinical translation;Collaborations;Communication;Computational Geometry;computerized tools;convolutional neural network;craniofacial;Craniofacial Abnormalities;Data;Data Science;Data Set;Decision Making;deep learning;deep learning algorithm;Development;Disease;early childhood;Etiology;Evaluation;Face;Failure;Fostering;Foundations;Friends;Functional disorder;Future;Goals;improved;innovation;interest;Investigation;large datasets;large scale data;life span;Live Birth;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Manuals;Measurement;Mechanics;Methodology;Methods;Mission;Morphology;Muscle;National Institute on Deafness and Other Communication Disorders;Nose;novel;operation;Operative Surgical Procedures;Oral;Outcome;patient population;Patients;Physiology;Plastic Surgical Procedures;precision medicine;Procedures;Process;Process Assessment;prospective;Quality of life;Recommendation;repaired;Reporting;Research;Sample Size;Second Look Surgery;Severities;Site;soft tissue;Speech;Strategic Planning;Structure;success;surgery outcome;Surgical Management;Technology;Testing;Time;Tissues;tool;tool development;Training;translational applications;Translational Research;Variant;Work

PROJECT_TITLE: Development of an MRI Guided Machine Learning Algorithm to Assess the Velopharyngeal Mechanism


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Machine learning-based predictors trained to distinguish between pathogenic and benign genetic variants have become an integral part of causal variant discovery and clinical variant classification. However, they have found limited use in genetic and genomic disease risk estimation, largely because the scores they output are not directly interpretable as disease risk, thus, making them inconsistent with current practices in genetic and genomic medicine. The objective of this study is to develop rigorous computational and statistical frameworks for the integration of variant pathogenicity predictors into the calculation of disease risk from single genes and whole genomes in a manner that is compatible with medical guidelines, accurate and clinically useful.

PI_NAMEs: PEJAVER, VIKAS RAO (contact)

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Address;Adoption;Advisory Committees;American;Benign;biobank;biomedical data science;Calibration;causal variant;Classification;Clinical;clinical decision-making;Code;cohort;Communities;Computer software;Data Science;Data Set;database of Genotypes and Phenotypes;Development;Development Plans;Disease;disease-causing mutation;disorder risk;Genes;Genetic;Genetic Medicine;genetic testing;genetic variant;Genome;genome-wide;genomic data;Genomic medicine;Genomics;Guidelines;Human Genome;Individual;Infrastructure;innovation;Lead;Machine Learning;machine learning algorithm;machine learning model;Measures;Medical;Medical Genetics;medical schools;Mendelian disorder;Methods;Modeling;Molecular Biology;molecular pathology;novel;Odds Ratio;open source;Outcome;Output;Pathogenicity;phenotypic data;polygenic risk score;Population Genetics;Prevalence;Principal Investigator;programs;Proteins;rare variant;Relative Risks;Reporting;Research;Resources;Risk;Risk Estimate;risk prediction;risk prediction model;risk variant;supervised learning;Terminology;Testing;tool;Training;Translating;United States National Institutes of Health;Untranslated RNA;Update;Variant;Weight;whole genome;Work

PROJECT_TITLE: Systematic integration of variant interpretation tools into genetic and genomic risk prediction

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (O2)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Pediatric;Prevention

ORG_CITY: KNOXVILLE

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: Project Narrative Strategic and interactive approaches driven by sociocultural, cognitive, and language theories have accumulated a large body of evidence documenting improvements in more complex oral and written language skills. Growing evidence demonstrates that more complex sign language skills positively predict literacy skills and may lead to improved health outcomes. This project involves new applications of theory-driven strategic and interactive approaches in an intervention program to target sign language development in deaf children between 5 and 8 years old who are at high risk of language delays.

PI_NAMEs: HOLCOMB, LEALA  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 8 year old;Academic skills;Acceleration;Address;Age;aged;Area;Articulation;Behavioral;career;Characteristics;Child;clinical application;Cognitive;cognitive function;Communication;Competence;Complex;critical period;Data;Data Collection;deaf;design;Development;disability;Dose;Educational Intervention;efficacy evaluation;efficacy testing;evidence base;executive function;experimental study;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Family;Foundations;Friends;Future;Goals;Health;high risk;implementation protocol;improved;Individual;innovation;Instruction;Intervention;intervention program;iterative design;Knowledge;Language;Language Delays;Language Development;Linguistics;literacy;Literature;Manuals;meetings;Modification;Monitor;National Institute on Deafness and Other Communication Disorders;Oral;Outcome;physical conditioning;Population;post intervention;Preparation;prevent;Process;Protocols documentation;Psyche structure;Randomized, Controlled Trials;remediation;Reporting;Research;Research Design;response;Sampling;scaffold;Short-Term Memory;Sign Language;skills;social;social culture;Standardization;teacher;theories;therapy design;Training;Work;Writing

PROJECT_TITLE: Strategic and Interactive Signing Instruction (SISI): An intervention program to support sign language development in deaf children


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_NAME: KANSAS CITY UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Breast cancer is a broad range of diseases that account for approximately 6% of all cancer-related deaths worldwide and ranks as the second most common cancer diagnosis among women. While much is known about breast cancer, elucidating the metabolic processes associated with poor patient outcomes, such as the development of chemotherapeutic resistance, is crucial. The proposed project will identify important genomic and phenotypic alterations in breast cancers due to the expression and activation of the pregnane X receptor (PXR) in response to pharmacotherapeutics commonly used in the treatment of breast cancer and identify new targets to treat breast cancer more effectively.

PI_NAMEs: CREAMER, BRADLEY ALLEN (contact);STAUDINGER, JEFFREY L

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: ABCB1 gene;Apoptosis;Biological Assay;Biological Sciences;Breast Cancer cell line;Breast Cancer Model;breast cancer progression;Breast Cancer Treatment;cancer diagnosis;Cancer Etiology;cancer type;Cell Cycle;cell growth regulation;Cell Survival;Cells;Cessation of life;Chemoresistance;Cities;college;Critical Pathways;CYP3A4 gene;Data;Dental;Development;Diagnosis;Disease;drug metabolism;Drug resistance;Drug usage;Effectiveness;Enzymes;Gene Expression Alteration;Gene Targeting;Genes;Genetic Transcription;Genomics;Goals;Homeostasis;Human;improved;In Vitro;innovation;Intestines;Invaded;Kansas;Knowledge;Liver;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Medicine;Metabolic;Metabolic Pathway;Metabolism;Modeling;Motility;Mutagens;Neoplasm Metastasis;neoplastic cell;Outcome;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Play;pregnane X receptor;Receptor Activation;receptor expression;Regulation;Research;response;Role;skills;Students;Testing;Therapeutic;therapeutic target;therapy resistant;Tissues;Training;transcription factor;transcriptome;transcriptome sequencing;Universities;women's diagnosis;Women's mortality;Xenobiotic Metabolism;Xenobiotics

PROJECT_TITLE: Investigating the Roles of Pregnane X Receptor in Human Breast Cancers

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cannabidiol Research;Cannabinoid Research;Chronic Liver Disease and Cirrhosis;Complementary and Integrative Health;Digestive Diseases;Hepatitis;Liver Disease;Natural Products;Nutrition;Obesity;Therapeutic Cannabinoid Research

ORG_CITY: GREELEY

ORG_NAME: UNIVERSITY OF NORTHERN COLORADO

ORG_STATE: CO

PHR: Project narrative Obesity-induced non-alcoholic fatty liver disease (NAFLD) and NAFLD-induced liver cancer are increasingly prevalent in the United States and worldwide with no FDA-approved medicine developed. This project aims to investigate the efficacy of Cannabigerol (CBG, a non- psychoactive component of cannabis) with or without combination of cannabidiol (CBD) in treatment of NAFLD/NASH, considering promising preliminary results. Successful completion of the studies can provide basis for a prospective treatment for chronic liver diseases and expand our understanding on how these diseases progress.

PI_NAMEs: HAN, YUYAN  (contact);PULLEN, NICHOLAS ALEXANDER

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Acute;Address;Alcohols;Animals;Anti-Inflammatory Agents;Antiinflammatory Effect;Antioxidants;Attenuated;Biological Assay;Body Weight;C57BL/6 Mouse;Cannabidiol;cannabigerol;cannabinoid receptor;cannabinoid treatment;Cannabinoids;Cannabis;CD3 Antigens;CD8B1 gene;Cells;cholangiocyte;choline deficient diet;chronic liver disease;Cirrhosis;comparison control;Complementary therapies;CXCR6 gene;cytokine;Cytometry;Data;Deposition;Derivation procedure;Diet;Disease;dosage;drinking water;efficacy evaluation;Enzyme-Linked Immunosorbent Assay;epidemiology study;Fatty Liver;FDA approved;Female;Fibrosis;Flow Cytometry;food consumption;Fructose;Future;Goals;group intervention;Hepatobiliary;Hepatocyte;Hepatotoxicity;High Fat Diet;Histologic;Human;IL2RA gene;Immune;immune cell infiltrate;Immunofluorescence Immunologic;In Vitro;in vivo;Infiltration;Inflammation;Inflammation Mediators;Insulin Resistance;Interleukin-2;Interleukin-6;Intervention;Left;Lipids;Liver;Liver Fibrosis;liver function;liver inflammation;liver injury;Lymphocyte Subset;male;Malignant neoplasm of liver;marijuana user;mast cell;Measures;Medicine;Metabolic syndrome;Methionine;Modeling;Molecular;mouse model;Mus;neuroprotection;non-alcoholic fatty liver;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;Obesity;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;Patients;peripheral blood;Physiological;Plants;Population;PPAR gamma;Prevalence;Primary carcinoma of the liver cells;prospective;PTPRC gene;Quantitative Reverse Transcriptase PCR;receptor;recruit;reduce symptoms;Reporting;Research;senescence;Solid;Spleen;Suspensions;Symptoms;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic Effect;Time;Tissues;TNF gene;transcriptome sequencing;Treatment Efficacy;treatment group;Ultraviolet Rays;United States;Weight;Western Blotting;Work

PROJECT_TITLE: The therapeutic effect of cannabigerol (CBG) with or without cannabidiol (CBD) in diet-induced non-alcoholic fatty liver disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Social Determinants of Health

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative Efforts to improve the diversity of the medical, biomedical and behavioral research workforce are important. This training program provides short-term research training experiences to college undergraduates that stimulate and sustain their interest in careers in the biomedical sciences and/or the health professions. By increasing the diversity of the biomedical and behavioral science workforce, the efforts of this proposal will enhance research efforts and positively impact health outcomes.

PI_NAMEs: LEWIS, BRIAN C (contact);MANDREKAR, PRANOTI

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Area;Award;Behavioral Research;Behavioral Sciences;Biomedical Research;Caliber;Cardiovascular Diseases;career;career networking;Clinical;college;Communication;Communities;cost;Degree program;Development;disability;Disability status;Doctor of Philosophy;Doctor's Degree;doctoral student;economic disparity;Economics;Educational Background;educationally disadvantaged;Eligibility Determination;Enrollment;Environment;epidemiology study;Ethics;ethnic disparity;Ethnic Origin;Event;experience;Faculty;Financial Support;Funding;Goals;graduate student;Growth;Health;Health Occupations;Hematological Disease;Human Resources;improved;Institution;interest;International;Investments;Laboratories;lectures;Lung Diseases;Massachusetts;Measures;Medical;Medical Research;medical schools;Medical Students;meetings;member;National Heart, Lung, and Blood Institute;Outcome;Participant;Postdoctoral Fellow;posters;Process;programs;Race;Reproducibility;Research;Research Assistant;Research Personnel;Research Support;Research Training;responsible research conduct;Science;Series;skills;social;Social Network;social organization;Structure;Students;success;support network;Training;training opportunity;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: UMass Chan Medical School Summer Undergraduate Research Program


NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE Age related macular degeneration (AMD) is a leading cause of vision loss in individuals over 55 years of age and is increasing as the population gets older. Treatment options for early AMD are limited, but evidence from observational studies suggests that whole foods, Mediterranean diets and low glycemic load (LG) diets are associated with lower progression of AMD and vision loss. Our goal is to assess the feasibility of a dietary intervention and plan for a future multicenter clinical trial to test a cost-effective approach to slow AMD progression and vision loss.

PI_NAMEs: HARTNETT, MARY ELIZABETH RUTH (contact)

PROGRAM_OFFICER_NAME: SHOAIBI, AZADEH

PROJECT_TERMS: 7-ketocholesterol;Address;Adopted;Advanced Glycosylation End Products;Affect;Age;Age related macular degeneration;Age Years;Animal Model;Basic Science;Behavior Therapy;Behavioral;Biological Assay;Biological Markers;Blindness;Blood Glucose;cardiovascular disorder risk;Clinical Trials;cohort;Complement;Consumption;Continuous Glucose Monitor;cost effective;data management;data tools;Deposition;design;Development;Diabetes Mellitus;Diet;dietary;Dietary intake;Dietary Intervention;Disease;dysbiosis;Elderly;Endocrinologist;Enrollment;Environment;epidemiology study;Europe;experimental study;Fasting;Feasibility Studies;Food;Functional disorder;fundus imaging;Future;Glucose;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Grant;Human;improved;Individual;innovation;insulin sensitivity;Intervention;Intervention Studies;Learning;Legal Blindness;legally blind;Lipids;Manuals;Measures;Mediterranean Diet;metabolic profile;metabolome;metabolomics;microbiome;Multi-Institutional Clinical Trial;Multicenter Studies;non-diabetic;Obesity;Observational Study;organizational structure;Outcome Measure;oxidation;Patients;Population;Procedures;prospective;Protocols documentation;Quality Control;recruit;Research;Research Support;Retina;retinal imaging;Retrospective Studies;Risk;Risk Factors;Risk Reduction;Sample Size;Site;Specialist;Techniques;Testing;Time;Tissues;tool;Unhealthy Diet;United States National Institutes of Health;Vision;western diet;willingness

PROJECT_TITLE: Feasibility Studies for the Future Mediterranean Glucose Lowering Dietfor Vision Extension in AMD (M-GLOVE-AMD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (01)]


NIH_SPENDING_CATS: Cancer;Machine Learning and Artificial Intelligence;Precision Medicine

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE My long-term goal is to build quantitative models that predict and circumvent cancer therapy resistance, specifically focusing on protein kinases currently targeted by over 75 FDA-approved inhibitors. Unfortunately, multiple kinase mutations have been found to resist known inhibitors and drastically reduce patient survival rates, and it remains unclear why these mutations induce such dramatic drug-resistance. Through a combination of high-throughput experiments, physics-based simulation, and machine learning based data-science methods, I will identify the mechanistic impact of clinically observed kinase mutants and build models that predict if a drug- resistant mutant is newly sensitive to alternative clinical therapeutics.

PI_NAMEs: SINGH, SUKRIT  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Affinity;Atlases;Benchmarking;Binding;Biophysics;cancer therapy;Clinical;clinical database;clinical predictors;cluster computing;Collaborations;computational platform;Computers;crizotinib;Data;Data Science;Data Set;Databases;drug repurposing;Drug resistance;Drug Targeting;Ensure;Enzymes;experimental study;FDA approved;Free Energy;Future;Goals;Grant;Home;Hybrids;improved;in silico;Induced Mutation;inhibitor;insight;kinase inhibitor;Left;Machine Learning;machine learning model;Malignant Neoplasms;Maps;markov model;Measures;Methods;model building;model generalizability;Modeling;Molecular;Molecular Conformation;molecular dynamics;mutant;Mutation;Non-Small-Cell Lung Carcinoma;optimal treatments;Oranges;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Phosphotransferases;Physics;Population;precision oncology;predictive modeling;Predisposition;Probability;Property;Protein Kinase;Regimen;Resistance;resistance mutation;Running;Signal Transduction;simulation;Structure;Survival Rate;Therapeutic;Time;treatment planning;Treatment Protocols;tumor;tumor progression;Work

PROJECT_TITLE: Quantitatively predicting drug-resistant mutations to improve precision oncology


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: FAYETTEVILLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: This project will provide public health researchers and policy makers qualitative, historical research to make sense of the quantitative materials emerging from Russia as well as the cultural resonance and popularity of Putin’s health campaigns. This research will root these programs in anxieties over a century of demographic challenges. By outlining programs from the Russian- Soviet-then-Russian state not to control women’s reproductive health but improve men’s behaviors this project will provide a new view of Russian pronatalism as a mask for anxiety over male weakness.

PI_NAMEs: STARKS, TRICIA  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Accidents;Address;Adult;Age;Alcohol consumption;Alcohols;American;Anxiety;Attention;Behavior;Birth;Birth Rate;Cardiovascular Diseases;Cessation of life;Consumption;COVID-19;Developed Countries;drinking;Drops;Economics;falls;Female;Fright;Funding;Future;Gender;Government;Harm Reduction;Health;Health Campaign;Heart Diseases;Image;Imagery;improved;International;Legal;Life;Life Expectancy;Longevity;male;male health;Malignant Neoplasms;man;Masks;men;Monograph;Policies;Policy Maker;Politics;poor health outcome;Population;Posture;programs;Public Health;Recovery;Regulation;Reporting;Research;Research Personnel;Russia;Smoke;Smoking;success;Tobacco;Tobacco use;Ukraine;War;warning label;Woman;women's reproductive health

PROJECT_TITLE: Save the Men! Russian Male Health in Crisis from the Revolution to Today

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 ZH-P (01)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Dissemination and Implementation Research;Mental Health;Mental Illness;Pain Research;Telehealth

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE This proposal is a partnership between Washington University and Wysa, a mental health app company, to refine an existing digital mental health intervention that addresses symptoms of depression and/or anxiety and coexisting chronic pain (Wysa for Chronic Pain) for the unique challenges and technology use patterns of middle-aged and older adults. Using a human-centered design approach, novel just-in-time adaptive interventions (JITAIs) will be created to improve the usability of Wysa for Chronic Pain for this target population. The real-world effectiveness of these adaptations will be assessed, and the final package of adaptations will be made widely available to the public by the completion of the study period.

PI_NAMEs: CHENG, ABBY LING-LEE (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: adaptive intervention;Address;Age;age group;American;Anxiety;anxiety symptoms;awake;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Caregivers;Caring;chatbot;Child;Chronic;chronic pain;chronic pain management;Clinical;clinically significant;Cognitive;Cognitive Therapy;depressive symptoms;design;digital;digital delivery;digital health;digital mental health;digital treatment;disability;Discover, Design, Build, and Test Framework;Educational process of instructing;effective intervention;Effectiveness;effectiveness evaluation;effectiveness/implementation study;effectiveness/implementation trial;Exercise;Functional impairment;Goals;Human;human centered design;human old age (65+);Hybrids;improved;Intervention;Interview;Link;literacy;Measures;Mediating;member;Mental Depression;Mental disorders;Mental Health;middle age;mindfulness;Mindfulness Training;Mobile Health Application;Modeling;Modification;novel;older adult;Pain;pain reduction;Participant;patient engagement;Patients;Pattern;Persons;physical conditioning;Pilot Projects;Population;preference;Prevalence;primary outcome;Professional counselor;Randomized;randomized trial;randomized, clinical trials;Reporting;Research;Series;Sleep;sleep quality;Specific qualifier value;Structure;Target Populations;Technology;technology intervention;Testing;Text;theories;Theory of Change;Time;tool;Universities;usability;Washington

PROJECT_TITLE: Digital mental health intervention for middle-aged and older adults with depression and/or anxiety and coexisting chronic pain

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative The goal of this application is to elucidate of how neutralizing and protective antibodies recognize structural ensembles of flavivirus virions. Understanding the structural basis of flavivirus virion antigenicity could facilitate the development of diagnostic reagents and new vaccine approaches.

PI_NAMEs: CROWE, JAMES E;DIAMOND, MICHAEL S (contact);FREMONT, DAVED H.;KUHN, RICHARD J.

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Adopted;Affect;Amino Acid Substitution;Amino Acids;Antibodies;Antibody Formation;Antibody Response;Antigens;B-Lymphocytes;Binding;Biophysics;Cell Separation;Cessation of life;Complex;Congenital Abnormality;Cryoelectron Microscopy;Dengue Virus;Development;diagnostic development;Diagnostic Reagent;Diamond;dimer;Distant;E protein;Encephalitis;Engineering;Epidemic;Epitopes;experimental study;Flavivirus;Gene Modified;Generations;Genes;Goals;high risk;human disease;human monoclonal antibodies;Immunization;Immunize;immunogenicity;improved;Incubated;Infection;insight;Life;Link;Maps;Microcephaly;Molecular Conformation;Monoclonal Antibodies;murine monoclonal antibody;Mus;Mutation;Nature;Neurologic;Neutralization Tests;neutralizing antibody;neutralizing monoclonal antibodies;novel;novel vaccines;Paper;particle;Powassan virus;prevent;Property;Publishing;Resistance;RNA Viruses;Sampling;Serotyping;Serum;Shock;Sorting;Structure;Surface;Syndrome;Temperature;Testing;therapeutic candidate;Therapeutic Monoclonal Antibodies;Tick-Borne Encephalitis Virus;tick-borne flavivirus;Time;Translating;vaccine development;vaccine platform;Vaccines;Variant;Viral;Virion;Virus;West Nile virus;Yellow fever virus;Zika Virus;Zika virus vaccine;ZIKV infection

PROJECT_TITLE: ANTIBODY-BASED PROTECTION AGAINST FLAVIVIRUSES

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Agent Orange & Dioxin;Behavioral and Social Science;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BRUNSWICK

ORG_NAME: BOWDOIN COLLEGE

ORG_STATE: ME

PHR: The proposed research project is relevant to public health because it is the first book-length interdisciplinary historical study of the environmental origins and consequences of a major chronic illness. Sweet Blood: Diabetes and the Changing Nature of Modern Health will benefit biomedical scientists, clinicians, historians of medicine, and public health experts by shedding new light on the deep historical antecedents to current social determinants of health. The project is germane to the Public Health Service because it explains how shifting relationships with mutable ecologies create or reinforce inequalities between individuals and populations, further driving diabetes prevalence alongside socioeconomic disparities.

PI_NAMEs: KLINGLE, MATTHEW WILLIAM (contact)

PROJECT_TERMS: agent orange;Animals;Automobile Driving;Behavior;biomedical scientist;Black race;Blood;Book Reviews;Books;Chemicals;Chronic Disease;Clinical Treatment;Collection;college;commercialization;comorbidity;Complications of Diabetes Mellitus;Congresses;Consult;Contracts;Diabetes Mellitus;diabetogenic;Diagnosis;Dioxins;Disease;Disputes;Ecology;Educational process of instructing;Environment;environmental change;Epidemic;Epidemiology;Etiology;Exposure to;falls;Funding;Gender;Gifts;global health;Grant;Health;health inequalities;Herbicides;History of Medicine;Human;Image;Individual;Inequality;Inequity;innovation;Insulin;interest;Journals;Knowledge;Length;Libraries;Literature;Location;Manuscripts;Maps;Medicine;Methodology;Microbe;Modernization;Nature;Newspapers;North America;Paper;Peer Review;Periodicals;Population;Prevalence;Prevention;Productivity;Public Health;Publications;Publishing;Race;Recording of previous events;Research;Research Project Grants;Running;sabbatical;Scholarship;Science;Scientist;Series;Services;Shapes;social;social determinants;social epidemiology;social health determinants;socioeconomic disparity;Source;teacher;Technology;Testing;Time;Training;Twin Multiple Birth;United States National Institutes of Health;United States National Library of Medicine;United States Public Health Service;Universities;Veterans;Vietnam;War;Washington;Work;Writing


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Precision Medicine;Telehealth

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO UNIVERSITY

PHR: Narrative Social anxiety is a highly prevalent and debilitating mental health concern, yet treatment strategies are difficult to access and do not work for everyone. Targeting specific mechanisms maintaining social anxiety is an important research goal and the current study will directly test a new brief self- guided internet-based treatment that addresses avoidance and attentional control as part of the intervention. The role of attention (where someone is looking) and audio vocal behavior (like how loud someone is speaking) on treatment outcomes will be tested to inform future experimental therapeutics, to better enhance and personalize treatments for social anxiety.

PI_NAMEs: RUBIN, MIKAEL  (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: 18 year old;Address;Adult;anxiety symptoms;arm;Attention;attentional control;Behavior;Caring;Clinical;Clinical Sciences;Clinical Trials;clinically significant;Cognitive Therapy;Communities;Computer software;COVID-19 pandemic;Data;Development;digital treatment;efficacious treatment;efficacy testing;Elements;Evidence based treatment;experience;Exposure to;Eye Movements;Fostering;Fright;Future;gaze;Goals;graduate student;Health Resources;Health Services Accessibility;Heterogeneity;Home;improved;Individual;individual response;individualized medicine;insight;International;Internet;Intervention;Investigational Therapies;Journals;Knowledge;Learning;Loudness;Mediating;Mediation;Mediator;member;Mental Health;Mentors;Modeling;new technology;next generation;Outcome;Participant;patient engagement;personalized medicine;Persons;Pilot Projects;Population;Prediction of Response to Therapy;Prevalence;Process;Protocols documentation;Publications;Randomized Controlled Clinical Trials;Reporting;Research;Research Methodology;Research Personnel;Role;Sampling;Scientist;screening;social;social anxiety;social factors;social interventions;social situation;symposium;Symptoms;Teleconferences;Testing;Therapeutic Intervention;Time;Training;training opportunity;Treatment Efficacy;treatment optimization;Treatment outcome;treatment response;treatment strategy;undergraduate student;virtual reality;virtual reality exposure;Visual attention;visual tracking;web-based intervention

PROJECT_TITLE: Testing the role of attentional and audio vocal mechanisms in a new internet-based intervention for social anxiety: iExposure

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Human behaviors seamlessly integrate perceptual and mnemonic information. To understand how the brain supports these abilities, this project will develop and evaluate biologically plausible computational models of medial temporal lobe-dependent behaviors, incorporating traditional neuroscientific methods within a deep learning framework. This integrated approach provides an unprecedented opportunity for understanding both typical and atypical memory-related behaviors, laying a foundation for future work to develop diagnostic and therapeutic tools to treat mnemonic-related disorders.

PI_NAMEs: BONNEN, TYLER  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Adaptive Behaviors;Address;Animal Behavior;Animals;Apical;Arbitration;Architecture;Articulation;awake;Award;Behavior;behavior measurement;Behavioral;Brain;clinical application;cognitive neuroscience;computer framework;Computer Models;conditioned fear;Data;deep learning;deep learning model;design;Diagnostic;discrimination task;Disease;Electrophysiology (science);Evaluation;Event;experience;Familiarity;Foundations;Functional Magnetic Resonance Imaging;Future;Human;in vivo;insight;Institution;Learning;Lesion;Macaca;Measurement;Measures;medial temporal lobe;Memory;memory recognition;Methodology;Methods;model building;Modeling;Monkeys;multimodality;Nature;Neuroanatomy;Neurobiology;neuroimaging;Neuropsychology;novel;object perception;Outcome;Participant;Pattern;Perception;Performance;Phase;Play;Positioning Attribute;Postdoctoral Fellow;Primates;Proxy;Psychological reinforcement;Research;Research Personnel;Research Project Grants;Resources;Role;Sensory;sensory cortex;sensory integration;shot learning;Stimulus;Structure;success;System;theories;Therapeutic;tool;Training;Variant;ventral visual stream;Visual;Visual Cortex;visual discrimination;Visual Perception;Visual System;Work

PROJECT_TITLE: Biologically Plausible Computational Models of Perirhinal Cortex


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative The study proposed in this F99/K00 application investigates the relationship between Heart Rate Variability (a measure of autonomic nervous system function) and brain states in healthy, moderate to heavy daily alcohol drinkers following periods of typical consumption and abstinence. To date, the study design has been completed and all data collected, with preliminary analyses run. The F99 phase of the project will involve the remaining analyses investigating connectivity changes with and outside of the Default Mode Network across drinking states, while future directions of the project, to be conducted during a postdoctoral fellowship and the K00 phase of this fellowship, will include more advanced dynamic assessments of brain states using functional networks.

PI_NAMEs: PETERSON-SOCKWELL, HOPE  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Abstinence;Academia;Acute;alcohol abstinence;Alcohol consumption;alcohol cue;alcohol exposure;alcohol use disorder;Alcohols;Attention deficit hyperactivity disorder;Autonomic Dysfunction;Autonomic nervous system;Behavior;Brain;career;Central Nervous System;Chronic;Cognitive;collaborative environment;Communities;Community Networks;Complex;Consumption;coping;craving;Data;Data Collection;Depressed mood;Development;discounting;Doctor of Philosophy;drinking;Educational process of instructing;Emotional;executive function;experience;Faculty;Fellowship;flexibility;Foundations;Functional Magnetic Resonance Imaging;Future;Goals;heart rate variability;Heavy Drinking;Imagery;Individual;Investigation;Knowledge;Learning;Link;Literature;Measures;Mentors;Methods;MRI Scans;Nervous System Physiology;neural;Neurobiology;Neurosciences;Participant;Patients;Peripheral;Peripheral Nervous System;Phase;Physiological;Postdoctoral Fellow;Prevention;Process;Productivity;Recovery;Regulation;Relapse;Research;Research Design;Research Personnel;Research Project Grants;resilience;response;Rest;Running;Scanning;Science;Series;skills;Stress;Structure;Students;System;Techniques;Time;Training;Variant;Youth

PROJECT_TITLE: Dynamic functional connectivity of the default mode network in youth with ADHD


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Hematology;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Brain pathologies such as neurodegenerative diseases and brain tumors have alterations in redox signaling. In the F99 phase of this proposal, brain tumor models are utilized to elucidate the mechanism by which brain tumor initiating cells suppress oxidative damage to promote their survival. For the K00 phase, continued studies with brain tumor models will shift focus to elucidate impacts on the bone marrow (BM) microenvironment to alter myeloid lineages and recruitment into the brain.

PI_NAMEs: TUY, KAYSAW C (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Award;Bioenergetics;biological adaptation to stress;Biological Assay;Biology;Blood - brain barrier anatomy;Blood Vessels;Bone Marrow;Bone Marrow Cells;Bone remodeling;Brain;Brain Neoplasms;Brain Pathology;cancer cell;Cell Death;Cell Death Induction;cell growth;Cell Maintenance;Cell Survival;Cells;Cellular Metabolic Process;Clinical;cofactor;Communication;cranium;Cues;Data;Denervation;Development;Disease;Disease Progression;Dopa-Responsive Dystonia;Enzymes;Epigenetic Process;experience;Fibroblasts;Genes;Genetic Transcription;Genomic Instability;Glioblastoma;Glioma;Glucose;Growth;GTP Cyclohydrolase;GTP Cyclohydrolase I;Hematologic Neoplasms;Hematopoietic stem cells;Immune;Immunosuppression;Immunotherapy;improved;Infiltration;Inflammation;inhibitor;Intervention;Investigation;Iron;Link;lipid metabolism;Lipid Peroxidation;Lipids;Lymphopenia;Maintenance;Malignant - descriptor;Malignant Neoplasms;Metabolic;Metabolism;metabolomics;Modeling;Myelogenous;Myeloid-derived suppressor cells;Myelopoiesis;nerve stem cell;nerve supply;Nervous System Disorder;neural;Neurodegenerative Disorders;neuroinflammation;neurotransmission;neurotransmitter uptake;Nitric Oxide;Non-Malignant;Nonesterified Fatty Acids;novel;Nutrient;nutrient deprivation;Oxidation-Reduction;oxidative damage;Oxidative Stress;Palmitates;Parkinson Disease;Pathology;Pathway interactions;patient prognosis;Patients;Penetrance;Pharmaceutical Preparations;pharmacologic;Phase;Play;Population;Postdoctoral Fellow;preclinical study;Predisposition;preservation;Production;Publishing;Reactive Oxygen Species;recruit;Recurrent tumor;Regulation;Reporting;Research;Resistance;Role;Sensory Receptors;Signal Transduction;stemness;Supporting Cell;tetrahydrobiopterin;Therapeutic;Therapeutic Intervention;Training;transcriptomics;tumor initiation;tumor microenvironment;Vascularization;Work

PROJECT_TITLE: Contribution of the Skull Bone Marrow during Neuroinflammation


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Regenerative Medicine

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Most cells of the central nervous system lose their ability to produce new neurons during early development, necessitating innovative approaches for replacing damaged neurons. Embryonic retinal pigment epithelium (RPE) cells can be induced to regenerate retinal neurons, and this proposal interrogates how changes in the RPE gene regulatory landscape culminate in a loss of regenerative competency. Together, the proposed research and training plan are foundations for building a career as a principal investigator exploring mechanisms of vertebrate central nervous system regeneration.

PI_NAMEs: TANGEMAN, JARED A (contact)

PROJECT_TERMS: Acute;Address;Adult;Amphibia;ASCL1 gene;ATAC-seq;Automobile Driving;Behavior;Binding;Binding Sites;Bioinformatics;Biological Assay;career;career development;Cell Differentiation process;cell type;Cells;Central Nervous System;Characteristics;Chick Embryo;Chickens;Chromatin;Cleavage Under Targets and Release Using Nuclease;Competence;computer infrastructure;Data;Data Analyses;data handling;data modalities;Data Set;Development;Development Plans;effective therapy;Embryo;Environment;epigenomics;Excision;experience;FGF2 gene;Foundations;Future;Gene Activation;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene regulatory network;Genes;Genetic Transcription;genome-wide;Genomics;Goals;Grant;Homeobox;Human;in silico;Injury;innovation;insight;Intervention;model organism;Modeling;Moderate Activity;mouse model;Multiomic Data;multiple omics;Natural regeneration;Nerve Regeneration;neural;Neural Retina;neurogenesis;neuron regeneration;neuronal replacement;Neurons;novel;novel strategies;Organism;Outcome;Output;outreach;pedagogical content;Phase;Pigmentation physiologic function;Population;Positioning Attribute;Postdoctoral Fellow;Principal Investigator;programs;regenerative;Regenerative capacity;Regenerative response;Replacement Therapy;Research;Resolution;Retina;retinal damage;retinal neuron;retinal regeneration;Role;Route;single nucleus RNA-sequencing;skills;Source;Structure of retinal pigment epithelium;System;Techniques;Time;Training;Training and Infrastructure;transcription factor;transcriptome sequencing;transcriptomics;treatment response;Vertebrates;Work;Writing;Zebrafish

PROJECT_TITLE: Elucidating the gene regulatory networks that drive neural regeneration


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Mental Health;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Despite the importance of social functioning to both health and psychiatric illness, relatively little is known about the neural processing mechanisms of live human face viewing. While activity in the right temporoparietal junction has been shown to distinguish live face viewing from humanoid robot face viewing, the neural features of that activity and their correlates in stimulus acquisition remain to be seen. This proposal will use simultaneous functional Near Infrared Spectroscopy, electroencephalography, eye-tracking, and pupillometry during live face and robot face viewing to test the hypothesis that visual sensing strategy is an active contributor to the neural processing of live human faces.

PI_NAMEs: KELLEY, MEGAN  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Academia;Address;advanced analytics;Appearance;Arousal;Attention;Behavior;Binding;Brain;career;Characteristics;Clinical;Code;cognitive system;complex data;Computer Models;Coupled;Coupling;Data;data acquisition;Data Analyses;data management;Data Set;Dedications;design;Development;Disease;Dyslexia;Electroencephalography;experience;Experimental Designs;experimental study;Eye;Eye Movements;Face;Face Processing;Factor Analysis;Follow-Up Studies;forging;Frequencies;Functional disorder;functional near infrared spectroscopy;Funding;gaze;Goals;Health;Human;humanoid robot;Impairment;Learning;Literature;Mental disorders;Mission;Motion;multimodal data;multimodality;neural;Neurocognition;Neurocognitive;neuromechanism;Participant;patient population;Patients;Perception;Phase;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Pupil;Research;Research Personnel;Research Project Grants;Robot;Role;Schizophrenia;showing emotion;simulation;skills;social;social cognition;Social Functioning;Social Interaction;source localization;Special Population;statistics;Stimulus;System;Techniques;Testing;theories;Time;Time Management;Training;Transcend;United States National Institutes of Health;Visual;visual tracking

PROJECT_TITLE: Basic neural processing mechanisms of live human face viewing