ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: NARRATIVE  One of the core questions in biology is how the genetic alteration in a cell translates into organ-level phenotype, especially for the phenotypes affecting human health. We propose to develop a multiscale, integrative imaging platform that probes organ-scale phenotype, subcellular phenotype, and single-cell genotype in the same tissue by innovating appropriate chemical and imaging tools. The new platform will help researchers identify the molecular basis of structural and functional abnormalities in diseased tissues and study how a focal point of abnormality affects nearby cells and propagates.

PI_NAMEs: HAN, HEE-SUN  (contact)

PROJECT_TERMS: Abnormal Cell;Address;Affect;autistic;Biological;Biology;Brain;Cell Communication;Cell Physiology;cell type;Cells;Cellular Morphology;Chemicals;Chemistry;Clustered Regularly Interspaced Short Palindromic Repeats;complex biological systems;Defect;Development;Disease;Environment;Functional disorder;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic manipulation;Genotype;Health;Human;Image;Imaging Device;imaging platform;In Situ;In Vitro;in vivo;Individual;innovation;intercellular communication;Link;Molecular;Molecular Abnormality;Multimodal Imaging;multiple omics;Mutation;Near-infrared optical imaging;Neurons;Organ;Organism;Pathogenicity;Phenotype;protein profiling;Proteomics;Quantum Dots;Research Personnel;RNA;Science;Series;Shapes;single cell sequencing;System;Technology;Thick;Tissue Engineering;Tissue imaging;Tissues;tool;transcriptome;transcriptomics;Translating

PROJECT_TITLE: Chemical toolbox for multiscale, integrative imaging: Connecting cellular gene expression to organ-scale phenotype


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PI_NAMEs: JOHNSON, DAVID K (contact)

PROJECT_TERMS: Affect;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Back;Biological Markers;Black Populations;Black race;Caring;Catalogs;Censuses;Cerebrovascular Disorders;Clinical;Clinical Research;clinically significant;Cognition;Cognitive;Cognitive aging;cohort;Color;Communities;Community Actions;community based participatory research;community engagement;Consent;Cultural Backgrounds;Data;Dementia;dementia burden;dementia risk;design;Development;digital;digital media;Disease;disease classification;Economics;Educational Background;effective therapy;Elderly;Environment;epidemiology study;ethnic minority population;Etiology;Event;experience;Faculty;Feedback;Goals;Health;high risk;Hispanic;Hispanic Populations;Impaired cognition;Incentives;indexing;Individual;interest;Knowledge;late life;Lead;Lesion;Magnetic Resonance Imaging;Marketing;Measures;Minority Recruitment;Not Hispanic or Latino;novel;older adult;outreach;Participant;Persons;Phase;Phenotype;Play;Population;Population Heterogeneity;Process;programs;Public Health;racial minority;Recording of previous events;recruit;Research;Resources;Risk;Role;Services;Site;social;social media;tailored messaging;Time;tool;trend;Underrepresented Populations;Vascular Diseases;vascular risk factor;Visit;white matter;White Matter Hyperintensity

PROJECT_TITLE: Recruitment and Retention Core


ADMINISTERING_IC: FD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: WASHINGTON

ORG_NAME: NATIONAL ACADEMY OF SCIENCES

ORG_STATE: DC

PHR: PROJECT SHORT NARRATIVE The purpose of the ILAR Roundtable is to foster communication and problem solving among the many different constituencies with strong interests in the use and welfare of laboratory animals in research and testing, including, government agencies, pharmaceutical and consumer product corporations, vendors, animal advocacy groups, professional societies, and academic institutions , including scientists and veterinarians. The objectives of all workshops organized by the ILAR Roundtable are to: 1 ) provide a forum in which to stimulate open dialogue, exchange information and foster communication ; 2) promote collaboration among a wide range of entities interested in the development of cutting edge laboratory animal research topics; and 3) facilitate discussion on more effective, efficient and humane use of animals and use of animal alternatives in biomedical research.

PI_NAMEs: BERGER, KAVITA MARFATIA (contact)

PROGRAM_OFFICER_NAME: ORR, ROBERT

PROJECT_TITLE: Workshops of the National Academies Roundtable on Science and Welfare in Laboratory Animal Use (ILAR Roundtable)


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Hematopoietic stem cells (HSCs) regenerate all blood and immune cells throughout life, but their function declines with age. This proposed fellowship will investigate the role of Heat shock factor 1 and Transglutaminase 2 in promoting protein homeostasis and HSC fitness during aging. Uncovering mechanisms that promote HSC function and regenerative capacity is critical for identifying therapeutic targets that can increase HSC fitness and immune function during aging, a critical need for an increasingly older population.

PI_NAMEs: ZHOU, FANNY JIAHUA (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: activation-induced cytidine deaminase;adaptive immunity;Age;age related;age related changes;age related decline;aged;Aging;Anemia;Binding;Binding Sites;Biogenesis;Biological Assay;Blood;Blood Cells;Blood Coagulation Disorders;Bone marrow failure;Cell Nucleus;Cell Survival;Cells;Cellular Stress;ChIP-seq;Cytoplasm;Data;DNA Sequence Alteration;Elements;Exhibits;experience;Fellowship;fitness;Gene Expression;Genes;Genetic Complementation Test;Genetic Transcription;hallmarks of aging;Health;Heat Losses;Heat shock proteins;heat shock transcription factor;heat-shock factor 1;Heat-Shock Response;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;hematopoietic stem cell aging;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Hematopoietic System;Human;Immune;immune function;Immunity;Impairment;improved;Incidence;Inflammation;insight;Knockout Mice;Laboratory Finding;Life;Lymphoid;middle age;misfolded protein;Molecular Chaperones;multicatalytic endopeptidase complex;Mus;Myelogenous;new therapeutic target;old mice;older adult;Older Population;Outcome Study;Oxidative Stress;Pathway interactions;preservation;prevent;Process;progenitor;programs;promoter;protein aggregation;Protein Biosynthesis;Protein Disulfide Isomerase;protein folding;Proteins;Proteome;proteostasis;proteostasis loss;proteotoxicity;reconstitution;regeneration function;Regenerative capacity;regenerative cell;Regulation;response;Role;self-renewal;single-cell RNA sequencing;stem cell aging;stem cell function;Stress;Testing;therapeutic target;trafficking;transcription factor;transcriptome sequencing;transglutaminase 2;Transplantation;Up-Regulation;young adult

PROJECT_TITLE: The Role of Hsf1 in Hematopoietic Stem Cell Aging


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PI_NAMEs: KELLER-HAMILTON, BRITTNEY L (contact)

PROJECT_TERMS: Acute;addiction;addiction liability;Address;Adult;Affect;Anabasine;Animal Model;Area;arm;base;Behavior;behavioral economics;Biochemical;Brain;cancer biomarkers;cancer risk;Characteristics;Cigarette;Cigarette Smoker;cost;Crossover Design;Dependence;design;Dimensions;Dizziness;Double-Blind Method;Drug Kinetics;Ecological momentary assessment;Ensure;Epithelium;experience;follow-up;Fostering;Gene Expression;Genes;Harm Reduction;Health;Health Benefit;High Prevalence;host microbiome;Human;indexing;Industry;Inflammatory;innovation;Isomerism;Laboratories;Manufacturer;Measures;Methods;Microbe;Modified Risk Tobacco Product;Nicotine;nicotine replacement;Nicotinic Agonists;Nicotinic Receptors;Ohio;Oral;oral microbiome;Outcome;Outcome Study;Participant;Persons;Phase;Plasma;Positioning Attribute;Preparation;Prevalence;Procedures;programs;Public Health;Randomized;Regulation;Reporting;Rewards;Risk;Sampling;Science;Smokeless Tobacco;smokeless tobacco user;Smoker;snus;Standardization;Taste Perception;Time;Tobacco;Tobacco Industry;tobacco products;Tobacco use;tobacco user;tobacco-free;Toxic effect;toxicant;Universities;uptake;Visit;Youth

PROJECT_TITLE: Project 2: Informing oral nicotine pouch regulations to promote public health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-R]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Infants with injuries concerning for abuse (e.g., extremity fracture) can have additional important injuries (e.g., brain injuries, certain additional fractures) that are clinically occult and only revealed with imaging. While neuroimaging can identify clinically occult head injuries from abusive head trauma, clinicians must weigh the neuroimaging-associated risks of sedation or radiation with the risks of missing a clinically or forensically important injury, while having little clinical guidance to inform their decisions. The proposed research is designed to benefit an AHRQ priority pediatric population through development of a clinical decision rule (CDR) that identifies which well-appearing infants undergoing abuse evaluations are at high risk of intracranial injury from abusive head trauma and warrant neuroimaging.

PI_NAMEs: HENRY, MARIA KATHERINE (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Optimizing targeted, equitable use of neuroimaging in cases of suspected infant physical abuse

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHICAGO

ORG_NAME: UCHICAGO ARGONNE, LLC

ORG_STATE: IL

PHR: GM/CA@APS is a national user facility that provides cutting-edge technologies for visualizing the 3D structures of protein and DNA molecules in atomic detail. Knowledge of 3D structures is essential to understanding how proteins and DNA perform their normal functions in living systems, how mutations in some proteins cause cancer progression, how drugs bind to their target proteins, how receptor proteins respond to external stimuli and transmit information from outside to inside the cell, how pathogens evade detection by our immune system, and how our proteins detect infection by pathogens. At the facility, an extremely intense, focused X-ray beam is scattered from proteins packed in a crystal. The X-ray scattering is measured and used to solve 3D structures by the method of X-ray crystallography. Located at the Advanced Photon Source, Argonne National Laboratory, GM/CA provides the sophisticated instrumentation and highly automated software necessary for recording and analyzing the scattering data used in 3D structure determination.

PI_NAMEs: FISCHETTI, ROBERT F. (contact);SMITH, JANET L.

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: 3-Dimensional;Address;Aging;Attention;beamline;Binding;Biochemistry;Cancer Etiology;Capital;Cells;cluster computing;Collimator;Communication;Communities;Community Outreach;Computer software;computerized data processing;computing resources;Coupled;Crystallography;Data;Data Analyses;data analysis pipeline;Data Collection;Data Storage and Retrieval;Deposition;Detection;detector;Devices;Diameter;DNA;Educational workshop;Ensure;Environment;Equipment;experience;experimental study;Failure;Feedback;Floor;Fluorescence;Friends;Funding;Goals;graphical user interface;Immune system;improved;Individual;Infection;instrument;instrumentation;Intuition;Knowledge;Laboratories;Macromolecular Complexes;Maintenance;Measures;Membrane;Methodology;Methods;Michigan;Modernization;Mutation;National Institute of General Medical Sciences;Nature;Noise;operation;Optics;Organism;outreach;Paper;pathogen;Peer Review;Performance;Periodicals;Pharmaceutical Preparations;Photons;Positioning Attribute;Preparation;programs;protein complex;protein structure;Proteins;Protocols documentation;Publishing;receptor;repaired;Resolution;Resources;Robotics;Roentgen Rays;Running;Sampling;Scanning;Schedule;Schools;Science;screening;Site;Source;Speed;Stimulus;structural biology;Structure;success;System;Technology;three dimensional structure;three-dimensional visualization;Time;tool;Training;transmission process;tumor progression;Universities;user-friendly;Viscosity;Visualization;X-Ray Crystallography

PROJECT_TITLE: GM/CA@APS: A Macromolecular Crystallography Resource


PI_NAMEs: FISCHETTI, ROBERT F. (contact)

PROJECT_TITLE: Administration Component

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-T]


ORG_CITY: DALLAS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative While the scaffolding protein Caveolin-1 has been implicated in disease progression in cancer, its precise role remains controversial. This proposal aims to leverage innovations in imaging, computational analysis, and zebrafish disease models to test the mechanosensory role of Caveolin-1 as a putative plasticity factor in Ewing Sarcoma, an aggressive pediatric bone and soft-tissue cancer. The anticipated results will reveal a mechanism of non-genetic cellular adaptation to diverse microenvironmental cues, providing unique insight into the drivers of metastasis and drug resistance.

PI_NAMEs: SEGAL, DAGAN  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Acute;Area;Biochemical;biological adaptation to stress;Biological Assay;Biology;Biosensor;Bone Tissue;Cancer Biology;cancer cell;Cancer Model;cancer type;caveolin 1;Cell Physiology;Cells;Childhood;Chimeric Proteins;Classification;Clinical Treatment;Computer Analysis;Computer Vision Systems;Cues;Data;Development;differential expression;disease model;Disease Progression;Drug resistance;Environment;Evolution;Ewings sarcoma;Experimental Models;Explosion;extracellular;Flow Cytometry;Foundations;functional plasticity;Gene Expression Profile;Genetic;Heterogeneity;high resolution imaging;Image;imaging approach;innovation;insight;knock-down;Knock-out;Laboratory Study;Lead;Malignant Childhood Neoplasm;Malignant Neoplasms;MAP Kinase Gene;mechanical force;mechanical signal;Mechanics;Membrane;Microscopy;Modality;Modeling;Molecular;Molecular Target;Morphology;Mutation;Neoplasm Metastasis;neoplastic cell;non-genetic;Oncogenic;Organizational Change;Osmotic Pressure;overexpression;Pathway interactions;Pattern;Physiological;post-doctoral training;Postdoctoral Fellow;Process;Proliferating;Ras Signaling Pathway;Regulation;Resources;response;Role;Scaffolding Protein;segregation;Signal Transduction;skills;soft tissue;spatiotemporal;System;Techniques;Testing;three dimensional cell culture;Three-dimensional analysis;Time;trafficking;Training;Tumor Promotion;tumorigenesis;Work;Xenograft procedure;Zebrafish

PROJECT_TITLE: The context-dependent role of Caveolin-1 as a driver of cellular adaptation in Ewing Sarcoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Cardiovascular;Complementary and Integrative Health;Heart Disease;Lung;Natural Products;Nutrition;Physical Activity;Prevention;Pulmonary Hypertension

ORG_CITY: MANHATTAN

ORG_DEPT: MISCELLANEOUS

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: PROJECT NARRATIVE  Pulmonary hypertension (PH) is a disease characterized by pulmonary vascular remodeling, impaired cardiac function, respiratory muscle weakness, and exercise intolerance; however, mechanisms underlying vascular dysfunction in respiratory and cardiac muscle with PH have never been determined. Therefore, using a unique combination of techniques (fluorescent microspheres, isolated blood vessel preparation, contractility measures), the current proposal will determine the distribution of diaphragm blood flow and diaphragm and coronary vasomotor function in PH rats with an emphasis on the therapeutic efficacy of pharmacological (Nrf2 activator) and exercise treatments to improve vascular and contractile function. The proposed experiments will enhance the knowledge of PH pathogenesis which may provide the foundation for development of therapeutic targets designed to improve blood flow regulation, survival, and quality of life in PH patients.

PI_NAMEs: SCHULZE, KIANA MARIE (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Acetylcholine;Anatomy;Animal Disease Models;Antioxidants;arteriole;base;Blood flow;Blood Vessels;Cardiac;career;Cessation of life;Coronary;Critical Thinking;cytokine;Data;Dependence;design;Development;Disease;Educational process of instructing;Elements;endothelial dysfunction;Endothelium;Environment;Exercise;exercise intervention;exercise intolerance;Exercise Therapy;exercise training;experimental study;Foundations;frontier;Functional disorder;Gases;Goals;Health;Heart;Heart failure;heart function;Impairment;improved;in vivo;Incubated;Inflammatory;insight;Kansas;Kinesiology;Knock-out;Knowledge;Laboratories;Measurement;Measures;Medial;Mediator;Messenger RNA;meter;Microspheres;Mitochondria;Molecular;Muscle Fatigue;Muscle function;Muscle Weakness;Myocardium;novel;nuclear factor-erythroid 2;Outcome;Oxidation-Reduction;oxidative damage;Oxidative Stress;Oxygen;Pathogenesis;Pathway interactions;Patients;Perfusion;pharmacologic;Physiological;Physiology;Preparation;preservation;protein expression;Pulmonary Hypertension;pulmonary vascular remodeling;Quality of life;Rattus;Reactive Oxygen Species;Regimen;Regulation;Relaxation;Research;Resistance;Respiration;Respiratory Diaphragm;Respiratory Muscles;Respiratory physiology;right ventricular failure;Role;sedentary;Skeletal Muscle;skills;Structure;Sulforaphane;Techniques;Testing;therapeutic development;therapeutic target;Time;Training;transcription factor;Transcriptional Activation;Treatment Efficacy;Universities;Up-Regulation;Vascular Diseases;Vascular resistance;Vasodilation;Vasomotor;Work;Workload

PROJECT_TITLE: Role for Nrf2 and exercise in mitigating pulmonary hypertension-induced vascular dysfunction


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

PI_NAMEs: SMITH, JANET L. (contact)

PROJECT_TERMS: Achievement;Area;base;beamline;Communication;Communities;Computer software;computerized data processing;Crystallography;data analysis pipeline;Data Collection;Data Set;data structure;detector;Development;Documentation;Education;Education and Outreach;Educational Activities;Educational process of instructing;Educational workshop;experience;experimental study;Goals;graphical user interface;improved;interest;Internet;Location;meetings;Methods;operation;outreach;Persons;Press Releases;Procedures;programs;Publications;remote location;Research;Resources;Role;Safety;Sampling;Schools;Site;structural biology;Students;symposium;Technology;Telephone;Time;Training;Travel;Update;Visit;web site;Writing

PROJECT_TITLE: User Training and Outreach Component


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Aging;aspirate;beamline;Capital;Computer software;computerized data processing;Crystallography;Data;Data Analyses;Data Collection;data integration;Data Set;density;detector;Diameter;Environment;Equipment;experience;experimental study;Failure;Floor;Friends;Funding;Goals;graphical user interface;improved;instrument;Intuition;Lead;Maintenance;Methods;Modernization;National Institute of General Medical Sciences;operation;Optics;Peer Review;Performance;Periodicals;Positioning Attribute;Process;programs;Protocols documentation;repaired;Resources;Roentgen Rays;Sampling;Scanning;Schedule;Scheme;screening;Site;Source;Speed;Structure;success;System;Testing;Time;user-friendly;Visualization

PROJECT_TITLE: Macromolecular Crystallography Operations Core


PI_NAMEs: MAYS, DARREN M (contact)

PROJECT_TERMS: abuse liability;Address;Adult;Affect;Behavior;behavior measurement;Behavioral;behavioral economics;Cigarette;Cognitive;Color;Communication;Dependence;design;Dimensions;Electronic cigarette;experimental study;Future;Goals;Harm Reduction;Human;Industry;innovation;interest;Label;Laboratories;laboratory experiment;Marketing;Measures;Methods;Modified Risk Tobacco Product;Nicotine;Nicotine Dependence;novel;novel strategies;Ohio;Oral;Perception;Persons;Predisposition;preference;Proliferating;Psychophysiology;Public Health;Regulation;Risk;risk perception;Sales;Sampling;Science;Smokeless Tobacco;smokeless tobacco user;Smoker;Source;Tobacco;Tobacco Industry;tobacco products;tobacco regulatory science;tobacco user;tobacco-free;tool;Toxic effect;Universities;Visual;young adult

PROJECT_TITLE: Project 3: Nicotine Product Claims on Appeal, Perceptions, and Use Behavior


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Nutrition;Obesity;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Epidemiologic studies identify that obesity and the related metabolic syndrome nonalcoholic fatty liver disease (NAFLD) are major risk factors of hepatocellular carcinoma (HCC). The goal of this proposal is to investigate how the nuclear receptor CAR regulates tumor lipid synthesis to promote HCC, and determine whether simultaneously blocking CAR and lipid uptake is therapeutically effective in obesity related HCC. 1

PI_NAMEs: DONG, BINGNING  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Affect;Agonist;Antihistamines;Cancer Etiology;CAR receptor;CD36 gene;Cessation of life;Clinical Trials;Combined Modality Therapy;Compensation;deprivation;Development;Diet;Effectiveness;epidemiology study;Essential Fatty Acids;Fatty Acids;FDA approved;feeding;Gene Expression;gene synthesis;Genetic Suppression;Genetic Transcription;Goals;Grant;Growth;High Fat Diet;Histamine Agents;Human;in vivo;Incidence;inhibitor;Knock-out;Link;lipid biosynthesis;lipid metabolism;Lipids;liver cell proliferation;Malignant Epithelial Cell;Malignant neoplasm of liver;Mediating;Metabolic syndrome;modifiable risk;Molecular;Mus;neutralizing antibody;non-alcoholic fatty liver disease;novel therapeutic intervention;Nuclear Receptors;Obesity;overexpression;pharmacologic;Primary carcinoma of the liver cells;programs;Repression;Risk Factors;Role;Testing;Therapeutic;Therapeutic Effect;therapeutic target;therapeutically effective;Toxic effect;tumor;tumorigenesis;uptake;Xenograft procedure

PROJECT_TITLE: Lipid Metabolism in Liver Cancer

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Genetics

ORG_CITY: STANFORD

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The initiation of DNA replication is tightly regulated to maintain genome integrity, yet the molecular mechanisms that underlie this fundamental process are poorly understood, especially in multicellular organisms. Key proteins involved in replication initiation are poorly conserved between yeast and humans, and mutations in these proteins cause genetic diseases. This project will employ a powerful single-molecule approach that we developed to dissect the mechanism of replication initiation, delineate the exact roles of replication initiation proteins, and understand why mutations in these proteins cause disease.

PI_NAMEs: CHISTOL, GHEORGHE  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Biochemical;Biological Markers;cancer cell;Cell Proliferation;Disease;DNA analysis;DNA biosynthesis;DNA-Protein Interaction;Genetic;Genetic Diseases;Genome;genome integrity;Genome Stability;Human;imaging platform;insight;Laboratories;Life;Malignant Neoplasms;Methods;Molecular;Mutation;new therapeutic target;novel;Oncogene Activation;Organism;overexpression;Peptide Initiation Factors;Process;Proliferating;Proteins;rare genetic disorder;Regulation;Replication Initiation;Replication Origin;Role;single molecule;Structure;Time;Visualization;Work;Yeasts

PROJECT_TITLE: Structure-Function Analysis of DNA Replication Initiation Factors Implicated in Disease

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE Atrial Fibrillation (AF) is the most common type of cardiac arrhythmia, affecting over 40 million people globally. Small conductance calcium-activated potassium channels (SK channels) retain a unique role in the integration of the intracellular Ca2+ and membrane potentials within the heart. Our approaches integrating patch-clamp, TIRF microscopy, super-resolution immunofluorescence imaging, optogenetics and genetic manipulations may elucidate the mechanism of SK2 channels regulation by PIP2, and present a potential, novel therapeutic target for atrial arrhythmias.

PI_NAMEs: TRINH, PAULINE  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Action Potentials;Affect;Arrhythmia;Atrial Fibrillation;Benign;Binding;Binding Proteins;Binding Sites;Calcium;Calcium-Activated Potassium Channel;calcium-activated potassium channel small-conductance;Cardiac;Cardiac Myocytes;Cell membrane;Clinical;Closure by clamp;Coronary Arteriosclerosis;Coupling;Fluorescence Microscopy;Functional disorder;genetic manipulation;Heart;Heart Abnormalities;Heart Atrium;Heart Diseases;Heart failure;heart rhythm;Human;human induced pluripotent stem cells;Image;Immunofluorescence Immunologic;induced pluripotent stem cell derived cardiomyocytes;insight;interdisciplinary approach;interest;Ion Channel;Knowledge;Laboratories;Life;Lipids;Maintenance;Membrane;Membrane Potentials;Membrane Proteins;Mentors;Mentorship;MicroRNAs;Molecular;mortality;Mus;Muscle Cells;Mutation;Myocardial dysfunction;new therapeutic target;novel;Nutrient;Optics;optogenetics;Organ;Oryctolagus cuniculus;Oxygen;patch clamp;Pathologic;Patients;Perfusion;Persons;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phosphorylation;Physicians;Physiological;Play;Potassium Channel;Protein Dephosphorylation;Protein Isoforms;Proteins;Regulation;Reporting;Role;Ryanodine Receptor Calcium Release Channel;Scientist;Signal Transduction;stem cell biology;sudden cardiac death;Techniques;Testing;therapeutic target;trafficking;Training;ultra high resolution;Ventricular

PROJECT_TITLE: Regulation of cardiac small-conductance calcium-activated potassium channels by PIP2


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Despite huge progress in understanding the biological function of every human gene, significant hurdles remain, among them to establish a systematic catalogue of cellular phenotypes associated with each gene. The pilot phase of the Molecular and Cellular Phenotypes of Null Alleles in Cells (MorPhiC) program will study the feasibility, scalability, required scope, and utility of such a catalogue. Our proposed Data Resource and Administrative Coordinating Center (DRACC) will develop and deploy infrastructure and tools to provide the highest quality MorPhiC data resource, analyze, annotate, and disseminate MorPhiC data, integrating external data & information, and serve as an administrative and coordination center.

PI_NAMEs: BURDETT, ANTHONY JOHN CHARLES;SCHURER, STEPHAN C (contact);SMEDLEY, DAMIAN ;YEUNG-RHEE, KA YEE

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Alleles;Aloral;Atlases;Big Data to Knowledge;Biological;Biological Assay;Biological Models;Biological Process;Catalogs;Cell Line;Cell model;Cells;cloud based;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;Complex;Computer software;computerized data processing;Controlled Environment;Data;Data Analyses;data management;data resource;Data Set;Data Sources;data standards;Dependence;Development;Disease;experience;FAIR principles;Feasibility Studies;Foundations;Future;Gene Expression;gene function;Genes;Genetic Diseases;Genetic Variation;Genome;genome wide association study;Human;Human Genome Project;human model;informatics infrastructure;Infrastructure;insight;Institution;International;knock-down;knockout gene;Knockout Mice;Leadership;Libraries;Life Cycle Stages;Maps;member;Metadata;model organism;Modeling;Molecular;molecular phenotype;Mus;National Human Genome Research Institute;Network-based;operation;Phase;Phenotype;portability;Positioning Attribute;Process;Production;programs;Protocols documentation;Quality Control;Reproducibility;Research;research and development;Resources;Specific qualifier value;Strategic vision;System;Techniques;Technology;Tissues;tool;Validation;Visualization;web portal;Whole Organism

PROJECT_TITLE: MorPhiC Data Resource and Administrative Coordinating Center


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE  This study seeks to link a group of hospitals to measure and share the rates of diagnostic errors, to understand underlying causes of diagnostic errors, and develop ways that hospitals, clinicians, and patients can work together to avoid diagnostic errors and harms due to those errors. We will test how data sharing and collaboration improve diagnostic processes and develop approaches which can be sustained into the future. Our approach represents a novel application of rigorous outcome adjudication to the problem of inpatient diagnostic errors using a learning health system model.

PI_NAMEs: AUERBACH, ANDREW D (contact);SCHNIPPER, JEFFREY LAWRENCE

PROGRAM_OFFICER_NAME: COSBY, KAREN

PROJECT_TITLE: Achieving Diagnostic Excellence through Prevention and Teamwork (ADEPT)


PI_NAMEs: FERKETICH, AMY K (contact)

PROJECT_TERMS: 3-Dimensional;addiction;Address;Adolescent and Young Adult;Adult;Age;base;Behavior;Categories;Characteristics;Cigarette;Classification;Complement;craving;Data;Dependence;design;Dimensions;Disparity;Ecological momentary assessment;Electronic cigarette;electronic cigarette use;Ensure;Environment;Equity;Evaluation;Evolution;experience;Fostering;Goals;Harm Reduction;improved;Industry;Isomerism;Laboratories;Laboratory Study;Lesbian Gay Bisexual Transgender;Manufacturer;Marketing;Mental disorders;Modified Risk Tobacco Product;Monitor;Nicotine;Nicotine Dependence;novel;Observational Study;Ohio;Oral;Outcome;Participant;Pattern;Perception;Persons;Population;population health;Proliferating;prospective;Public Health;queer;Recording of previous events;Regulation;Research;Risk;risk perception;rural dwellers;Sales;Salts;Sampling;Science;Sensory;Smokeless Tobacco;smokeless tobacco user;Smoker;social;Surveys;Time;Tobacco;tobacco advertising;Tobacco Industry;tobacco products;Tobacco use;tobacco user;trend;United States Food and Drug Administration;Universities;Withdrawal;Youth

PROJECT_TITLE: Project 4: A Naturalistic Observation of Electronic Cigarettes and Oral Nicotine Pouch Product Use Among Adolescents and Young Adults


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE Neovascular glaucoma (NVG) is a potentially blinding secondary glaucoma characterized by anterior segment neovascularization, leading to elevated intraocular pressure and poor visual prognosis. The objective of this proposal is to investigate the role of Angiopoietin-like 4/Neuropilins, alone or in combination with VEGFs, as regulators of iris/angle neovascularization. The ultimate goal of our investigations is to design better therapeutic modalities for the prevention and treatment of NVG.

PI_NAMEs: MONTANER, SILVIA V (contact);SODHI, AKRIT SINGH

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Adjuvant;Affinity;Angiogenesis Inhibitors;Angiogenic Factor;Angle-Closure Glaucoma;ANGPTL4 gene;Animal Model;antagonist;Anterior;anterior chamber;aqueous;Aqueous Humor;Area;Binding;blood vessel development;Blood Vessels;cell motility;central retinal vein occlusion;Clinical Management;combinatorial;Conjunctival Pterygium;Cornea;Corneal Neovascularization;Data;design;Development;diabetic;Diagnosis;diagnostic biomarker;Diffuse;Diffusion;Disease;Disease Management;Early identification;effective therapy;Eye;Eye diseases;gene product;Glaucoma;Goals;Growth;Hypoxia;In Vitro;in vivo;inhibitor;insight;Investigation;Iris;Ischemia;Light Coagulation;Medical;Membrane;Methods;Modality;Molecular;Neovascular Glaucoma;neovascularization;Neuropilin-1;Neuropilins;novel;novel diagnostics;novel therapeutics;NRP1 gene;Open-Angle Glaucoma;Operative Surgical Procedures;Pathogenesis;Patients;Physiologic Intraocular Pressure;prevent;Prevention;Prevention approach;Prevention therapy;Process;Prognosis;proliferative diabetic retinopathy;receptor;Refractory;response;Retina;Retinal Diseases;retinal ischemia;Risk;Role;Secondary to;sickling;Signal Transduction;Stimulus;Surface;Syndrome;synergism;targeted treatment;Therapeutic;therapeutic target;therapeutically effective;Tissues;Trabecular meshwork structure;Treatment Protocols;Uveal Melanoma;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;vein occlusion;Visual;Visual impairment

PROJECT_TITLE: Elucidation of novel anti-angiogenic therapies for the prevention and treatment of neovascular glaucoma


ORG_CITY: PROVIDENCE

ORG_DEPT: PEDIATRICS

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE – OVERALL The Universities, Hospitals and Community Organizations in Rhode Island are well positioned to bridge the gaps between the worlds of clinical and basic science. Using the targeted resources of an IDeA-CTR Award, the Brown Institute for Translational Sciences, and a statewide consortium of collaborators, hospitals, universities, non-profit organizations and government agencies, will draw on the resources already developed in the NIH Institutional Development Award (IDeA) programs (core labs and faculty development programs) to enhance the Advance Clinical and Translational Research Program’s (Advance-CTR) ability to support clinical and translational research. We will serve as a bench-to-bedside research network and career development umbrella for the investigator community in affiliated institutions. In so doing, we will enhance patient-centered research and accelerate discoveries and health innovations to benefit our communities and to serve our State.

PI_NAMEs: ROUNDS, SHARON IRENE SMITH (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Acceleration;Address;Area;Award;Basic Science;bench to bedside;Big Data;Biological;biomedical informatics;Biometry;career;career development;Caring;Clinical;clinical application;Clinical effectiveness;clinical infrastructure;clinical practice;Clinical Research;Clinical Sciences;clinical translation;Collaborations;Communities;community engaged research;community engagement;Community Mental Health Services;community organizations;Community Outreach;Core Facility;cost;COVID-19;Data;demographics;Development;Discipline of Nursing;Education;Environment;Epidemiology;Evolution;Extramural Activities;Fostering;Funding;Funding Opportunities;Future;Goals;Government Agencies;Grant;Health;health care delivery;health disparity;health equity;Health Policy;Health Priorities;Health Services;Health system;Healthcare Systems;Home;hospital organization;Hospitals;Human Resources;improved;Infrastructure;innovation;Institution;laboratory development;life span;Mentors;Modeling;multidisciplinary;National Institute of General Medical Sciences;New England;Nonprofit Organizations;organizational structure;Outcome;patient oriented;Pharmacy facility;Pilot Projects;Population;Positioning Attribute;prevent;Productivity;Program Development;Program Evaluation;programs;Protocols documentation;Public Health;Publications;Research;Research Design;Research Infrastructure;Research Personnel;Research Proposals;Research Support;Resources;Rhode Island;Services;success;synergism;Teacher Professional Development;Testing;Training;Translating;Translational Research;translational research program;translational scientist;United States National Institutes of Health;Universities;virtual;Vulnerable Populations

PROJECT_TITLE: Advance Clinical and Translational Research (Advance-CTR)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The mechanisms underlying the loss and recovery of consciousness from general anesthesia remain poorly understood. This project aims to use human cerebral organoids, which are brain-like structures derived from human pluripotent stem cells, to isolate the molecular mechanisms that cause induction and emergence from anesthesia. Completion of this project may not only aid in the development of methods aimed at actively inducing recovery of consciousness from anesthesia, but may also lay the foundation for using human cerebral organoids in the search for interventions for pathological states of unconsciousness, such as coma and vegetative states, for which there currently no treatments or animal models.

PI_NAMEs: TOKER, DANIEL  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: 3-Dimensional;Acetylcholine;Aminobutyric Acids;Anesthesia procedures;Anesthetics;Animal Model;Area;Assessment tool;awake;Awareness;basal forebrain;Brain;care costs;Cerebrum;Chemosensitization;cholinergic;Clinical;Coma;Complex;Conscious;Delirium;Development;Dopamine;Embryo;Entropy;Event;excitatory neuron;Exhibits;experience;Exposure to;Feedback;Foundations;Frequencies;General Anesthesia;high throughput screening;Histamine;Human;human induced pluripotent stem cells;human pluripotent stem cell;human tissue;hypocretin;Hypothalamic structure;improved;In Vitro;in vivo;Induced pluripotent stem cell derived human neuron;inhibitory neuron;Intervention;Lateral;Length of Stay;locus ceruleus structure;mammilloinfundibular nucleus structure;Mediating;method development;Modeling;Molecular;neural;neural circuit;Neuroglia;Neurons;neuroregulation;noradrenergic;Norepinephrine;novel;novel therapeutics;Organoids;Pathologic;Patients;Persistent Vegetative State;phenomenological models;Play;Process;Propofol;Protocols documentation;raphe nuclei;receptor;Recovery;Research;respiratory;Role;screening;Structure;System;Testing;Thalamic structure;Time;tool;Unconscious State;Vegetative States

PROJECT_TITLE: Causal mechanisms of anesthetic induction and emergence in human cortical organoids


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE - OVERALL This P01 aims to improve therapy for Pancreatic cancer, one of the most lethal of cancers, and nonmelanoma skin cancer, the most ubiquitous cancer in the United States. We use visible light activation to not only destroy the cancer itself, but also to increase the efficacy of other treatments such as chemotherapy and immunotherapy while minimizing the toxicity associated with the latter. Our overall strategy includes two clinical trials (in Projects 1 and 2), and preclinical studies (Project 3) which together will ultimately allow patient customized combination treatments that will benefit even those patients whose disease has stopped responding to any of the conventional treatments.

PI_NAMEs: HASAN, TAYYABA  (contact);MAYTIN, EDWARD V

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Acceleration;Animals;anti-PD-1;Automobile Driving;Behavior;Biological Markers;Budgets;cancer therapy;cancer type;Categories;checkpoint inhibition;chemotherapy;Clinical;Clinical Research;clinical translation;Clinical Trials;cohort;Collaborations;Combined Modality Therapy;confocal imaging;conventional therapy;cost;cytotoxic;design;Development;Diagnostic;Disease;Dose;dosimetry;Economic Burden;Eligibility Determination;Endoscopic Ultrasonography;Endoscopy;Environment;Excision;Fibroblasts;Fluorouracil;Future;high resolution imaging;Human;Image;image guided;Imaging Device;Immune;immune cell infiltrate;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immunocompetent;immunogenic cell death;Immunologic Monitoring;Immunologics;immunoregulation;Immunotherapy;improved;Incidence;Industry;Infiltration;innovation;Knowledge;Learning;Lesion;Literature;lymph nodes;Lymphocyte Subset;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Microsatellite Instability;Modeling;Molecular;Molecular Target;Monitor;Morbidity - disease rate;mortality;mouse model;Mus;novel;optical imaging;Optics;Organoids;Outcome;Pancreatic Adenocarcinoma;pancreatic cancer model;pancreatic cancer patients;Pancreatic carcinoma;Pancreatic Ductal Adenocarcinoma;Pathway interactions;patient subsets;Patients;Pattern;PD-1/PD-L1;Peer Review;pembrolizumab;Permeability;pharmacologic;pre-clinical;Pre-Clinical Model;preclinical study;Process;Prognosis;Program Research Project Grants;programmed cell death protein 1;programs;Proteins;Publications;PUVA Photochemotherapy;Radiology Specialty;radiomics;recruit;Regimen;Research;Research Project Grants;response;side effect;Skin Cancer;Skin Carcinoma;success;symposium;T-Cell Activation;T-Lymphocyte Subsets;Techniques;Therapeutic;Time;tool;Toxic effect;treatment response;treatment strategy;tumor;Tumor Escape;tumor microenvironment;Tumor-Infiltrating Lymphocytes;ultrasound;United States;Verteporfin;Visible Radiation;Vitamin D;Work;X-Ray Computed Tomography

PROJECT_TITLE: Photodynamic Priming of Cancer and Image-guidance for Optimal Immune Response


ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Graft injury is unavoidable during heart transplant procedures, where surgical procedures and graft ischemia times will generate potent immune responses that may contribute to the development of immunosuppressant- resistant fibrosis and vasculopathy leading to chronic rejection. This proposal will study how macrophage recognition of allogeneic MHCI components within the graft confounds their reparative functions. I will also define novel macrophage allorecognition pathways and target them to evaluate if this blocks chronic rejection.

PI_NAMEs: WARUNEK, JORDAN  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Acceleration;Address;Alloantigen;Allogenic;angiogenesis;Antibodies;Apoptotic;Automobile Driving;B-Lymphocytes;Binding;Biochemistry;Bioinformatics;Biological Assay;Biotinylation;Bone Marrow;career;Cells;Cellular Immunology;Chronic;Cicatrix;Clinical;Co-Immunoprecipitations;Collaborations;Complex;cytokine;Data;Dendritic Cells;Development;Disease;Early identification;Enzymes;Exposure to;Extracellular Matrix;Fibroblasts;Fibrosis;Flow Cytometry;Fostering;Foundations;FRAP1 gene;Generations;glucose uptake;Graft Rejection;Graft Survival;H2 gene;heart allograft;Heart Transplantation;Homeostasis;Immune response;Immunoglobulins;Immunology;Immunosuppressive Agents;In Vitro;in vivo;Inbred BALB C Mice;Incubated;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injury;insight;interest;Ischemia;isoimmunity;Knockout Mice;Ligation;Lymphocyte;Macrophage;Macrophage Activation;Major Histocompatibility Complex;Manuscripts;Mediating;Mentorship;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Molecular;Molecular Immunology;monocyte;Myocardial Ischemia;Natural Killer Cells;NF-kappa B;novel;Operative Surgical Procedures;Organ;Organ Preservation;Organ Transplantation;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern;Phenotype;Phosphorylation;PLCgamma2;post-transplant;Postdoctoral Fellow;Preparation;prevent;Procedures;Process;programs;Proteins;Proteomics;Reaction;receptor;receptor-mediated signaling;Recombinants;repair function;repaired;Reperfusion Injury;Research;Research Personnel;Resistance;resistance mechanism;response;restoration;Role;Shapes;Signal Induction;Signal Transduction;single-cell RNA sequencing;Site;Solid;stem cells;Structure of thyroid parafollicular cell;symposium;T-Lymphocyte;Testing;Time;tissue repair;Tissues;Training;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Organisms;Transplantation;Vascular Diseases;wound healing

PROJECT_TITLE: Defining How Macrophage Allorecognition Impacts Tissue Repair After Transplantation


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: PADBURY, JAMES F (contact)

PROJECT_TERMS: Advisory Committees;Award;Basic Science;Bioinformatics;Biological Sciences;Biology;biomedical informatics;Biometry;Businesses;career;Caring;Clinical;clinical infrastructure;clinical investigation;clinical practice;Clinical Research;Clinical Sciences;clinical translation;Collaborations;college;Communication;Communities;community engagement;Community Outreach;cyber infrastructure;Databases;Development;Discipline;Discipline of Nursing;Ecosystem;Education;Engineering;Ensure;Environment;Epidemiology;epidemiology study;Evaluation;experience;Extramural Activities;Fostering;Funding;Funding Opportunities;Goals;Government Agencies;Growth;Health;Health Policy;Healthcare;Healthcare Systems;Home;Hospitals;improved;industry partner;Institution;inter-institutional;Knowledge;Leadership;life span;medical schools;Medicine;Mentors;Mission;Modeling;New England;operation;organizational structure;Pharmacy facility;Phenotype;Pilot Projects;Policies;Population;population based;Procedures;Process;Program Development;programs;Public Health Schools;Research;Research Activity;Research Design;Research Infrastructure;Research Personnel;Research Support;Resources;Rhode Island;Running;Schools;Services;Source;Structure;success;Surveys;System;Teacher Professional Development;Training;Translational Research;Universities;Writing

PROJECT_TITLE: Administrative Core


PI_NAMEs: WAGENER, THEODORE LEE (contact)

PROJECT_TERMS: Accountability;Achievement;Adult;Budgets;Collaborations;Communication;Data;data sharing;Dimensions;Electronic cigarette;electronic cigarette use;Ensure;Evaluation;experience;Fostering;Funding;Goals;Grant;Industry;Information Dissemination;Institution;Isomerism;Judgment;Knowledge;Leadership;Logistics;Manuscripts;Marketing;Measures;meetings;Nicotine;Occupational activity of managing finances;Ohio;Oral;Pattern;Persons;Pilot Projects;Product Packaging;Public Health;public policy on tobacco;Regulation;Reporting;Research;Research Personnel;Resource Allocation;Resource Sharing;Schedule;Science;Services;smokeless tobacco user;Smoker;Structure;Tobacco;Tobacco Surveillance;tobacco user;Toxic effect;translational impact;Travel;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core (AC)


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Genetics;Immunization;Immunotherapy;Nanotechnology;Neurodegenerative;Neurosciences;Prevention;Vaccine Related

ORG_CITY: BUFFALO

ORG_NAME: POP BIOTECHNOLOGIES, INC

ORG_STATE: NY

PHR: Project Narrative The objective of this proposed project is to develop a multivalent "mosaic" vaccine, termed SNAP-AD, targeting multiple epitopes of Aβ and tau simultaneously with a novel spontaneous nanoliposome antigen particle (SNAP) vaccine system and to investigate its therapeutic effects for treating Alzheimer’s disease (AD) in a transgenic mouse model. A positive outcome of this project would potentially lead to a novel vaccine for the treatment of AD and AD-related dementia, which would have an immense impact on the health of our society.

PI_NAMEs: DAI, CHUNLING ;HUANG, WEI-CHIAO  (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: 3xTg-AD mouse;abnormally phosphorylated tau;Affect;Age;Alzheimer Vaccines;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;American;Amyloid beta-Protein;Animals;Antibodies;Antibody Response;Antigens;Anxiety;Basic Science;Behavior;behavior test;Biochemical;Biotechnology;Brain;C-terminal;Clinical Trials;cognitive function;Collaborations;COVID-19 vaccine;Dementia;Developmental Disabilities;Disease;Dose;drug development;Drug Kinetics;Epitopes;Etiology;Exhibits;extracellular;Goals;Health;Human;Immune;Immune system;Immune System Diseases;Immunization;Immunize;immunogenic;Immunotherapy;Impaired cognition;improved;Individual;innovation;Institution;Intervention;Lipids;Liposomes;manufacture;Methods;mosaic;Motor Activity;mouse model;Mus;N-terminal;nanoliposome;nanoparticle;Nature;Neurofibrillary Tangles;neuroinflammation;new therapeutic target;New York;novel;novel vaccines;Outcome;particle;Pathogenesis;Pathology;Peptides;Pharmaceutical Preparations;Phase;phase 1 study;phase 3 testing;Phase II Clinical Trials;preclinical study;prevent;Preventive;Proteins;Protocols documentation;Pyroglutamate;Quality of life;Reproducibility;Research;response;Rodent Model;Role;Safety;Senile Plaques;Societies;Surface;System;tau Proteins;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic target;therapeutic vaccine;therapeutically effective;Transgenic Mice;vaccine development;Vaccines;Wild Type Mouse

PROJECT_TITLE: Mosaic Display of Multivalent Tau and A-Beta peptides on Immunogenic SNAP Liposomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-P(11)B]


PHR: Stroke-related disability - including cognitive impairment and dementia - is a public health epidemic and a key national research priority in the United States. Because of its disproportionately high impact on health disparity populations, understanding the mechanisms of post-stroke cognitive decline is a matter of equitable health care delivery. DISCOVERY, the proposed collaborative nationwide network of clinical sites with access to diverse acute stroke US populations has the expertise, experience and capacity to execute a large prospective study that will unravel the mechanisms of post-stroke cognitive disability, early recovery after stroke, and potential targets for personalized prevention, intervention, and rehabilitation.

PI_NAMEs: GREENBERG, STEVEN M;ROST, NATALIA S (contact)

PROGRAM_OFFICER_NAME: GARCIA, LINA FERNANDA

PROJECT_TERMS: Acceleration;Acute;acute stroke;Address;Adult;Alzheimer's disease related dementia;Amyloid beta-Protein;Aneurysmal Subarachnoid Hemorrhages;Biological Markers;Blood;Blood Vessels;Brain;Brain Injuries;Brain Pathology;burden of illness;Cerebral hemisphere hemorrhage;cerebrovascular;Characteristics;Classification Scheme;Clinical;clinical application;clinical research site;Clinical Trials;Clinical Trials Design;Cognitive;cognitive disability;cognitive load;cohort;Cohort Studies;comorbidity;Complex;deep learning;Dementia;dementia burden;dementia risk;disability;Environmental Risk Factor;Epidemic;epigenomics;Equitable healthcare;Ethnic Origin;Evaluation;Event;exome sequencing;experience;experimental study;Exposure to;functional outcomes;Future;General Population;Genetic;Genetic Predisposition to Disease;genome wide association study;Genomics;Goals;health care delivery;health disparity;health disparity populations;Hemorrhage;hospital care;Hour;imaging biomarker;Impaired cognition;improved;Incidence;indexing;Individual;individual patient;individualized prevention;Inflammation;Intervention;Intervention Trial;Ischemia;Ischemic Stroke;Knowledge;Leadership;Lesion;Life Cycle Stages;Liquid substance;Location;Magnetic Resonance Imaging;Measurable;Mediating;Methylation;Microvascular Dysfunction;Modeling;morphometry;multiple omics;Nerve Degeneration;neuroimaging;non-demented;Outcome;outcome prediction;Participant;Pathologic;Pathology;Patient Selection;patient stratification;Patients;Perfusion;personalized medicine;Population;population based;Population Heterogeneity;Positron-Emission Tomography;post stroke;post stroke cognitive impairment;Predisposition;prevent;Prevention trial;Process;prognostication;prospective;Prospective Studies;Public Health;Race;Recovery;recruit;Rehabilitation therapy;repository;Research;Research Priority;resilience;response;Risk;Risk Factors;Role;Series;Serum;sex;statistics;Stroke;stroke cognitive outcome;stroke event;stroke patient;stroke recovery;Subgroup;Symptoms;synergism;tau Proteins;Testing;Time;Translations;United States;Variant;vascular injury;vascular risk factor

PROJECT_TITLE: DISCOVERY: Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative This project aims to identify mechanisms by which the brain links reward values to specific past and future actions, as well as to understand how the functions of evaluating past rewards and predicting future rewards are subdivided within the brain. This is likely to provide knowledge that will be relevant for drug addiction and other compulsive disorders.

PI_NAMEs: SJULSON, LUCAS L (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Address;Animals;Automobile Driving;awake;Brain;cell type;Choice Behavior;Code;Collection;Consumption;Corpus striatum structure;Decision Making;Detection;Disease;Drug Addiction;drug relapse;Drug usage;Evaluation;Exhibits;Future;Hippocampus;in vivo;Knock-in Mouse;Knowledge;Link;Measures;Mus;Neurons;new therapeutic target;novel;optogenetics;Pattern;Physiological Processes;Population;Predictive Value;Process;Property;Public Health;Relapse;reward processing;Rewards;Silicon;Site;Sleep;Synapses;Testing;therapeutic target;therapeutically effective;Time;transcriptomics;Update;Ventral Striatum

PROJECT_TITLE: Hippocampal interactions with striatal subnetworks for reward prediction and evaluation

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence

ORG_CITY: ARLINGTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: Project Narrative Improvement of optical microscopy that provides high spatial and temporal resolution can impact numerous fields of biomedical research. I propose to combine a novel microscopy technique and advanced computational post- processing to provide the next generation of imaging tools for biomedical researchers. This technology will help to move biomedical research forward by understanding subcellular events to tissue-level outcomes that are critical in cell biology or pathophysiology.

PI_NAMEs: LEE, JUHYUN  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Algorithms;attenuation;automated segmentation;Behavior;Behavioral;Biomedical Research;cell behavior;Cell model;cell motility;Cell Physiology;Cell Shape;Cell Size;Cells;Cellular biology;cellular imaging;deep learning;Dependence;detector;Dimensions;Ensure;Evaluation;Event;Fluorescence;Functional disorder;high resolution imaging;Histopathology;Image;Imaging Device;Imaging Techniques;improved;in vivo;in vivo monitoring;Individual;Lateral;learning network;lens;Light;Maximum Likelihood Estimate;mechanical stimulus;Microscope;Microscopic;Microscopy;migration;millimeter;Modality;Monitor;Morphogenesis;Morphology;Motion;nanometer;nanometer resolution;nanoscale;next generation;Noise;novel;optical imaging;Optics;Organism;Organogenesis;Outcome;Phenotype;Research Personnel;Resolution;response;restoration;sensor;Signal Transduction;spatiotemporal;Techniques;Technology;temporal measurement;Tissues;Training;ultra high resolution

PROJECT_TITLE: High spatiotemporal optical imaging to study dynamics of 3D cell motion and behavior in living organisms


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: WILSON, IRA B (contact)

PROJECT_TERMS: Address;Attention;Award;career;Certification;Clinical;Clinical Research;Communities;community engaged research;community engagement;Competence;Curriculum Management System;Development;Education;Educational Curriculum;Educational workshop;Entrepreneurship;Equity;evidence base;Evolution;experience;Extramural Activities;Faculty;Feedback;Funding;Funding Mechanisms;Funding Opportunities;Goals;Grant;Health;health care disparity;health disparity;Health Priorities;Healthcare;human subject;improved;Individual;infrastructure development;innovation;K-Series Research Career Programs;Learning;Mental Health;mentoring community;Mentors;National Institute of General Medical Sciences;Obesity;overdose death;Participant;Personal Satisfaction;Phase;Pilot Projects;Population;population health;Positioning Attribute;Preparation;programs;Recommendation;Research;Research Infrastructure;Research Personnel;Resources;response;Rhode Island;Science;Secure;senior faculty;Series;Services;skills;Structure;tool;Training;training opportunity;Training Programs;Translational Research;Underrepresented Populations;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Professional Development Core


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PROJECT_TERMS: abuse liability;Academia;Acceleration;Address;Analytical Chemistry;Applications Grants;Basic Science;behavioral economics;behavioral pharmacology;Cancer Center;Cancer health equity;career;career development;Cells;clinical center;Clinical Sciences;Clinical Trials;Collaborations;Competence;Comprehensive Cancer Center;Data Analyses;design;Development;Dimensions;early-career faculty;Ecological momentary assessment;Education;Environment;Evaluation;experience;Exposure to;Faculty;Faculty Recruitment;Feedback;Fostering;Funding;Future;Goals;graduate student;Grant;health equity;Human;Individual;Industry;Infrastructure;Institution;Intervention Studies;Isomerism;Journals;K-Series Research Career Programs;Knowledge;laboratory experiment;Lawyers;Leadership;lectures;marginalized population;Measurement;Mentors;Mentorship;Mission;Modeling;Monitor;next generation;Nicotine;Observational Study;Occupations;Ohio;Oncology;Outcome;outreach;Pilot Projects;Policies;Positioning Attribute;Postdoctoral Fellow;Principal Investigator;process evaluation;Professional Organizations;Program Evaluation;programs;Psychophysiology;Public Health;recruit;Research;Research Activity;Research Personnel;Research Project Grants;response;Science;Scientist;skills;Societies;Source;Structure;Students;success;Tobacco;tobacco control;Tobacco Industry;tobacco products;tobacco regulatory science;Toxic effect;Training;Training Activity;Training and Education;training opportunity;Training Programs;Translational Research;undergraduate research experience;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Career Enhancement Core


ORG_CITY: MINNEAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Brain function is built atop connections made between neurons. The proposed Center for Mesoscale Connectomics will use multiple imaging and neuroanatomical methods across nonhuman primates and humans to build an accurate, fine-grained wiring diagram of the brain. We will start with connections between the frontal and parietal lobes, with the eventual goal of mapping connections across the whole brain.

PI_NAMEs: AKKIN, TANER ;FAIR, DAMIEN A;HEILBRONNER, SARAH RACHEL;LENGLET, CHRISTOPHE ;UGURBIL, KAMIL  (contact);YACOUB, ESSA ;ZIMMERMANN, JAN

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TERMS: Anatomy;Attention;Axon;Behavior;Brain;Brain Mapping;Brain region;Central Nervous System;Cognition;Communication;Complex;Computer Analysis;connectome;Data;data acquisition;Data Analyses;Data Collection;Data Set;Decision Making;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;executive function;Fiber;fluorescence imaging;Foundations;frontal lobe;Funding;Goals;Grain;Human;human subject;Image;Imaging Techniques;in vivo;Injections;Joints;Label;Link;Literature;Macaca;Macaca mulatta;Magnetic Resonance Imaging;Maps;meter;Methods;Minnesota;Modality;Modeling;multimodality;neural network;Neural Pathways;Neuroanatomy;Neurons;nonhuman primate;novel;Optical Coherence Tomography;optical imaging;Parietal;Parietal Lobe;Pattern;Population;Protocols documentation;Research Personnel;Resolution;Structure;Techniques;Tissues;tool;tractography;Universities;Variant;Visualization

PROJECT_TITLE: BRAIN CONNECTS: Center for Mesoscale Connectomics


PHR: PROJECT NARRATIVE: Bacterial respiratory tract infections are the most common reason for hospitalization in children with tracheostomy (an artificial airway placed in the neck that allows children to breathe), yet there is very limited evidence available to help prevent, diagnose or treat this condition. This AHRQ R01 project will evaluate 1500 hospitalizations in children hospitalized at one of five freestanding children's hospitals to determine what factors influence clinicians to diagnose and treat suspected bacterial tracheostomy-associated infections, such as pneumonia, with antibiotics. Through our multicenter prospective study, we expect to identify strategies to reduce antibiotic exposure and hospitalizations in this vulnerable patient population that account for increased health care utilization.

PI_NAMEs: RUSSELL, CHRISTOPHER JOHN (contact)

PROGRAM_OFFICER_NAME: MILLER, MELISSA

PROJECT_TITLE: Diagnosis and management of pediatric tracheostomy-associated infections

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


PI_NAMEs: EL HELLANI, AHMAD  (contact)

PROJECT_TERMS: abuse liability;Acute;addiction;Adolescent and Young Adult;Adult;Affect;Air;American;analytical method;Behavior;cardiovascular endothelium;Cardiovascular system;Cell Culture Techniques;Cells;Cessation of life;Characteristics;Chemicals;Cigarette;Cigarette Smoker;Complement;Data;design;Dimensions;Disease;e-cigarette aerosols;Electronic cigarette;electronic liquid;Epidemic;Epithelium;Equipment;Evaluation;evidence base;experience;Formulation;Goals;Grant;Harm Reduction;Health;heated tobacco products;High Prevalence;hookah;Human;improved;in vitro testing;Industry;innovation;Intervention Studies;Isomerism;Knowledge;Laboratories;Lebanon;Liquid substance;Lung;Mainstreaming;Malignant Neoplasms;Manuscripts;Marketing;Measurement;microbial;microbial composition;Modeling;Monitor;never smoker;Nicotine;novel;Ohio;Oral;Oral Tobacco;Output;Pathway interactions;Perception;Pilot Projects;Play;Policies;population health;Prevalence;programs;Property;Public Health;Publications;Qualifying;quality assurance;Quality Control;Records;Regimen;Regulation;Research;Research Design;Research Personnel;Resources;response;Role;Sales;Science;skills;smokeless tobacco user;Standardization;Techniques;Testing;timeline;Tobacco;Tobacco Industry;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;Toxic effect;toxicant;Toxicology;United States Food and Drug Administration;Universities;uptake;vaping;Work;Youth

PROJECT_TITLE: Product Evaluation and Manipulation Core (PEMC)


PI_NAMEs: SCHMID, CHRISTOPHER H. (contact)

PROJECT_TERMS: Address;analytical method;analytical tool;Area;Bioinformatics;biomedical informatics;Biometry;Clinical;Clinical Research;Collaborations;Communities;community engagement;Community Outreach;Community Participation;Consultations;cyber infrastructure;Data;Data Analyses;Data Collection;Decision Making;design;Development;Diffusion;Discipline;Education;Educational Models;Educational process of instructing;Educational Technology;Enrollment;Environment;Epidemiology;experience;faculty research;Foundations;Goals;Health;health data;Health protection;improved;Infrastructure;innovation;Institution;Investments;Learning;Link;Methods;Modality;multidisciplinary;Persons;Phase;Pilot Projects;programs;Qualifying;Qualitative Research;Research;Research Design;Research Personnel;Research Support;Resources;Rhode Island;satisfaction;Schedule;skills;Structure;tool;Training;Training Support;Translational Research;translational scientist;Universities;web portal;web site;Work

PROJECT_TITLE: Biostatistics, Epidemiology, and Research Design Core


NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Pathogenic collagen-producing fibroblasts accumulate and persist at sites of fibrosis in progressive silica- associated pulmonary fibrosis. We hypothesize that targeted removal of collagen1a1-expressing fibroblasts through genetic ablation or sensitization to apoptosis after Bcl-2 knockdown will reduce fibrosis in a silica-induced progressive fibrosis mouse model. The results of our studies should provide insight into the dependence of fibrosis progression on Col1a1-expressing fibroblasts and development of novel therapeutic strategies to stop fibrosis progression that will improve the outcomes for patients with silica-induced fibrotic lung disease; as there are currently no FDA approved therapies.

PI_NAMEs: FOSTER, DANIEL G (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Ablation;Address;Affect;Alveolus;American;Apoptosis;Apoptotic;Automobile Driving;BCL2 gene;Cells;Cessation of life;Cicatrix;Collagen;Dependence;Deposition;Development;Diphtheria;diphtheria toxin receptor;Disease Progression;Dust;Excision;Exposure to;Extracellular Matrix;FDA approved;Fibroblasts;Fibrosis;fibrotic lung;fibrotic lung disease;Flow Cytometry;Gases;Genetic;Histologic;Hydroxyproline;Image;Impairment;improved outcome;in vivo evaluation;inducible gene expression;Industry;Inhalation;insight;knock-down;Label;Location;Lung;Measures;Mediator;Methods;microCT;Mining;Modeling;Molecular;mouse model;Mus;Myofibroblast;novel;novel therapeutic intervention;Outcome;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Population;Predisposition;prevent;Process;profibrotic fibroblast;Proteins;Pulmonary Fibrosis;Pulse Oximetry;Resistance;Respiratory Failure;response;Risk;Risk Factors;Signal Transduction;Silicon Dioxide;Silicosis;Site;Stains;Structure of parenchyma of lung;Testing;Therapeutic Intervention;Therapeutically Targetable;Time;Tissues;Toxin;Work;wound healing

PROJECT_TITLE: Targeted Death of Collagen1a1-Expressing Fibroblasts Reduces Silica-Induced Pulmonary Fibrosis


PI_NAMEs: SHANG, CE  (contact)

PROJECT_TERMS: abuse liability;addiction;Address;Adult;Algorithms;Assessment tool;career;Categories;Code;Collection;combustible tobacco;Data;data dissemination;Data Sources;Databases;design;Development;Dimensions;Drops;Electronic cigarette;electronic cigarette use;Ensure;Evaluation;Experimental Designs;experimental study;Fostering;Goals;Industry;innovation;interest;Isomerism;Manufacturer;Marketing;medical specialties;Methodology;Methods;Mission;Monitor;Natural Language Processing;Nicotine;Nicotine Dependence;novel;Ohio;Oral;Pattern;Persons;Pilot Projects;Play;Policies;policy recommendation;Product Packaging;Public Health;Publications;Questionnaires;Recording of previous events;Regulation;Research;Research Design;response;Role;Science;Smokeless Tobacco;Source;Standardization;Stimulus;Surveys;Tobacco;tobacco advertising;Tobacco Industry;tobacco products;Tobacco Surveillance;Tobacco use;tobacco user;Toxic effect;translational impact;translational potential;trend;Universities;vaping;Vendor;Visual;web site

PROJECT_TITLE: Marketing Monitoring Core (MMC)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: NUNN, AMY STEWART (contact)

PROJECT_TERMS: Address;Africa;African American;Award;Bioinformatics;Black race;burden of illness;China;Cities;Clinical;clinical practice;Clinical Research;Communities;community collaboration;community engaged research;community engagement;Community Health;Community Outreach;Community Participation;community setting;Counseling;Data Analyses;Data Collection;Disparate;Elements;Ensure;Epidemiology;ethnic diversity;experience;Feedback;General Population;Goals;Grant;Health;health disparity;Health Personnel;Health Priorities;Home;Human Resources;Immigrant;improved;India;Infrastructure;Intervention;Knowledge;Latinx;Latinx population;Leadership;learning community;Medical Care Team;member;Mentors;Mission;New England;Outcome;Patients;personalized approach;Philosophy;Policies;Policy Maker;Population;practice-based research network;primary care practice;Process;Production;programs;Public Policy;Publications;racial diversity;Reduce health disparities;Relationship-Building;Research;Research Activity;research and development;Research Design;Research Methodology;Research Personnel;Research Project Grants;research study;Research Support;Rhode Island;Solid;Southeastern Asia;success;System;Testing;Time;Training;Translating;Translational Research;translational research program;Writing

PROJECT_TITLE: Community Engagement and Outreach Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_DEPT: NEUROLOGY

PHR: Project Narrative Postural instability and gait disturbances are important factors contributing to decreased mobility, falls and reduced quality of life in people with Parkinson’s disease, yet the mechanisms contributing to these motor signs are poorly understood and current treatments are often insufficiently effective. This project will use transcranial magnetic stimulation, deep brain stimulation (DBS) and patient-specific computational models of DBS, in conjunction with quantitative measures of motor function to explore the hypothesis that neuronal pathways projecting to the extensor muscles of the ankle are preferentially affected in PD in comparison to ankle flexors, and these abnormalities contribute to deficits in gait. These experiments will increase our understanding of the impact of disease and DBS on leg muscle function in PD which could lead to refinement and/or development of therapies to improve postural stability and gait in people with PD.

PI_NAMEs: LECY, EMILY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Acute;Affect;aging population;Ankle;Axon;Basal Ganglia;behavior measurement;Behavioral;Bradykinesia;Brain Stem;comparison control;Computer Models;Data Collection;Deep Brain Stimulation;Development;Disease;dopamine replacement therapy;Efferent Pathways;experimental study;Extensor;falls;Flexor;Force of Gravity;Future;Gait;Gait abnormality;Gastrocnemius Muscle;Generations;Globus Pallidus;Half-Life;Human;Impairment;improved;Individual;insight;Intervention;Knowledge;Leg;Length;Levodopa;Lower Extremity;Measures;Mediating;Methods;Mobility decline;Modeling;Morbidity - disease rate;Motor;Motor Cortex;Motor Evoked Potentials;Movement;multimodality;Muscle;Muscle function;muscle strength;Neural Pathways;Neurodegenerative Disorders;Neurons;neurophysiology;North America;novel;Outcome;Parkinson Disease;Participant;Pathway interactions;Patients;Performance;Persons;Phase;Physiologic pulse;Play;Posture;posture instability;Prevalence;Process;Property;Quality of life;Reaction Time;Research;Resistance;response;Role;Scientist;skills;Soleus Muscle;Structure of subthalamic nucleus;Testing;Therapeutic Effect;therapy development;tibialis anterior muscle;Torque;Training;Transcranial magnetic stimulation;Upper Extremity;Walking

PROJECT_TITLE: EFFECTS OF DISEASE AND PALLIDAL DEEP BRAIN STIMULATION ON ANKLE MUSCLE CONTROL IN PARKINSON'S DISEASE


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Immunotherapy;Radiation Oncology;Skin Cancer

PHR: NARRATIVE – Project 1 This project will advance new therapeutic approaches that use photodynamic therapy (PDT), 5-fluorouracil, and Vitamin D as immune-priming agents, with subsequent addition of immune checkpoint inhibition (ICI) for the treatment of advanced squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), which together represent the most common of all human cancers. Preclinical experiments in mouse models, and clinical studies in patients with SCC and BCC, will be done with the aid of advanced optical fluorescence techniques provided by Core B and Core C to detect changes in initial photosensitizer levels and immune cell recruitment post-PDT. These experiments will allow us to determine the precise timing of increased checkpoint molecule expression and recruitment of specific populations of immune cells into tumors after PDT treatment, thereby establishing a rationale and a therapeutic window for designing a new combination treatment regimen that will benefit patients by improving treatment outcomes for advanced SCC and BCC.

PI_NAMEs: MAYTIN, EDWARD V (contact)

PROJECT_TERMS: 3-Dimensional;Aminolevulinate;anti-PD1 antibodies;anti-tumor immune response;arm;Basal cell carcinoma;Biological Models;Blood;Blood specimen;Blood Vessels;cancer infiltrating T cells;Cancer Patient;cancer therapy;Cells;checkpoint inhibition;checkpoint therapy;Clinical Research;Clinical Trials;Collaborations;Combined Modality Therapy;comparative;Cytometry;cytotoxic;Data;design;Dimensions;Dose;dosimetry;Ensure;Excision;experimental study;Exposure to;Fluorescence;Fluorouracil;Future;Goals;healthcare burden;Histologic;Human;Image;image guided;Immune;immune activation;immune cell infiltrate;immune checkpoint;Immune checkpoint inhibitor;Immune response;immunogenic cell death;Immunologic Markers;Immunologics;immunomodulatory therapies;Immunotherapy;improved;in vitro Model;Inbred HRS Mice;innovation;Lymphocyte;Macrophage;Malignant Epithelial Cell;Malignant Neoplasms;Measures;Metabolic Clearance Rate;Modeling;Mohs Surgery;Molecular;Mononuclear;Morbidity - disease rate;mortality;mouse model;Mus;Nature;Neoadjuvant Therapy;neoplastic cell;neutrophil;Neutrophil Infiltration;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Optics;optimal treatments;Oral;organ transplant recipient;Organoids;overexpression;Patient Recruitments;patient subsets;Patients;Pattern;Peripheral Blood Mononuclear Cell;Photosensitizing Agents;Pilot Projects;Population;pre-clinical;preclinical study;programmed cell death protein 1;Proteins;PUVA Photochemotherapy;recruit;Regimen;Risk;Safety;Skin Cancer;Skin Carcinoma;Skin Neoplasms;skin squamous cell carcinoma;Societies;Squamous cell carcinoma;Subgroup;T-Cell Activation;T-Lymphocyte;Techniques;Testing;Therapeutic;therapy resistant;three dimensional cell culture;Three-dimensional analysis;three-dimensional modeling;Time;Tissues;Toxic effect;TP53 gene;Treatment Failure;Treatment outcome;Treatment Protocols;treatment response;tumor;tumor microenvironment;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;UV induced;UV Mutagenesis;Verteporfin;Vitamin D

PROJECT_TITLE: Project 1: 5FU and Vitamin D as Neoadjuvants for Photodynamic Priming to Enhance Skin Cancer Therapy


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE The persistence of chronic pulmonary sequelae following acute respiratory viral diseases such as COVID-19 is developing into a significant public health burden, however the mechanisms underlying this condition remain unknown. Aged individuals in particular, are at increased risk of adverse long-term outcomes after severe viral pneumonia. The goal of these studies is to understand how persistent immune dysfunction post infection, a consistent feature in aged individuals, contributes to impaired alveolar regeneration and dysplastic lung repair.

PI_NAMEs: NARASIMHAN, HARISH  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Accounting;Acute;Acute Disease;Address;Adopted;adverse outcome;age related;aged;Aging;aging population;Alveolar;alveolar epithelium;Area;Bioinformatics;Bronchoalveolar Lavage Fluid;CD8B1 gene;Cell Differentiation process;Cells;Cessation of life;Chronic;Chronic Disease;Coculture Techniques;Coupled;COVID-19;Cytokeratin 8;cytokine;Data;Data Set;Development;Epithelial Cells;epithelial stem cell;Exhibits;Fibrosis;Genetic;Goals;healthcare burden;Healthcare Systems;high dimensionality;high risk;Human;human old age (65+);Immune;Immune response;Immune system;Immune System Diseases;Impairment;improved;In Vitro;in vivo;Individual;Infection;Inflammation;Influenza;Injury;insight;Interleukin-1 beta;Kinetics;Lung;Lung Capacity;lung repair;Macrophage;Maintenance;Mediating;Memory;Middle East Respiratory Syndrome;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Myelogenous;Natural regeneration;Organoids;Outcome;pandemic disease;Pathologic;Pathology;Phase;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;Predisposition;Process;Public Health;pulmonary function;Pulmonary Inflammation;Recovery;repaired;Reporting;respiratory;Rhinovirus;Risk;Role;SARS coronavirus;SARS-CoV-2 infection;self-renewal;Severities;Signal Transduction;single-cell RNA sequencing;spatial integration;Stains;System;T memory cell;Techniques;Therapeutic;Time;Tissues;transcriptomics;Transitional Cell;Viral;Viral Pneumonia;Viral Respiratory Tract Infection;Virus;Virus Diseases

PROJECT_TITLE: Immune-epithelial progenitor interactions drive age-associated dysplastic lung repair post viral pneumonia


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Prevention

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE Immune checkpoint inhibitors (ICIs) are new cancer immunotherapy agents that are effective in treating some advanced and metastatic cancers and improve the likelihood of patients living with the disease. Since we still know little about their survivorship needs, we aim to characterize the long-term survival and physical and psychosocial symptom trajectories of patients treated with ICIs for advanced and metastatic cancer. Our findings are expected to provide much-needed data that can inform new evidence-based intervention strategies to optimize cancer survivorship care for these patients.

PI_NAMEs: KAMEN, CHARLES STEWART;SAKODA, LORI ;YAO, SONG  (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Address;Adopted;advanced disease;Advanced Malignant Neoplasm;Age;Behavioral;behavioral health;Biological Markers;Body Composition;California;Cancer Center;cancer diagnosis;cancer immunotherapy;cancer survivorship care;cancer therapy;cancer type;Caring;checkpoint therapy;Clinical;clinical practice;clinical predictors;cohort;community academic partnership;Companions;Comprehensive Cancer Center;Data;demographics;design;Diagnosis;Dimensions;Disease;Disease remission;Disseminated Malignant Neoplasm;Enrollment;Ethnic Origin;Evidence based intervention;FDA approved;follow-up;Health behavior;Immune checkpoint inhibitor;Immune response;Immunotherapeutic agent;Immunotherapy;improved;In complete remission;Inferior;Infusion procedures;Intervention;ipilimumab;Learning;Length;Life Style;Longitudinal Studies;Maintenance Therapy;Malignant neoplasm of lung;Malignant Neoplasms;Melanoma;Metastatic Melanoma;Modeling;Mutation;partial response;Patient Outcomes Assessments;patient population;Patients;Phase;Population;Predictive Factor;predictive marker;Preparation;Prognosis;programmed cell death ligand 1;Progression-Free Survivals;Prospective cohort;psychosocial;Psychosocial Factor;psychosocial wellbeing;Quality of life;Race;racial disparity;Renal Carcinoma;response;sex;side effect;Sister;survival prediction;Survivors;survivorship;Symptoms;Therapeutic;tumor;Universities;Unresectable

PROJECT_TITLE: A Multi-Institute Survivorship Study of Patients Living with Advanced Cancer Who Have Had Durable Response to Immune Checkpoint Inhibitors


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases;Skin Cancer

PHR: NARRATIVE – Project 2 Pancreatic cancer is a deadly disease that is very resistant to chemotherapy, partly because the tumor is encased in a fibrous shell that helps the cancer disguise itself from the body's immune system. The purpose of this project is to create an immunologically-based treatment that first damages the primary pancreatic tumor using a light activated drug that disrupt the fibrous shell (allowing chemotherapeutic treatments to reach the cancer), and also causes the tumor to release damage signals that permit the patients' own immune system to identify and attack the cancer. This research could help immune-activating drugs (currently ineffective on their own) to become more effective for treating pancreatic cancer, both the primary lesions as well as distant metastases.

PI_NAMEs: WANG, KENNETH K (contact)

PROJECT_TERMS: Abscopal effect;advanced pancreatic cancer;Adverse event;Area;aspirate;Basal Cell Cancer;Biological Markers;Blood Vessels;Cancer Patient;cancer recurrence;CD8-Positive T-Lymphocytes;Cells;Cessation of life;Characteristics;chemotherapy;Clinic;Clinical;clinical outcome assessment;college;Combined Modality Therapy;Common Terminology Criteria for Adverse Events;cytotoxic;Development;Disease;Distant Metastasis;dosimetry;Endoscopic Ultrasonography;Fine needle aspiration biopsy;Flow Cytometry;Fluorescence;Goals;Granzyme;Hour;Image;image guided;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immune system;Immunologic Stimulation;Immunotherapy;improved;in vivo;indexing;Inflammatory Infiltrate;Intravenous;Intravenous Bolus;Left;Light;London;Lymph Node Tissue;lymph nodes;Lymphocyte;Lymphocyte Subset;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Malignant Squamous Cell Neoplasm;Measurement;Melanoma;Metastatic Neoplasm to the Lung;microendoscopy;Microsatellite Instability;Molecular;Monitor;Mus;Necrosis;Necrosis Induction;Needles;Neoplasm Metastasis;optical fiber;Oral mucous membrane structure;Outcome;pancreatic cancer model;pancreatic cancer patients;Pancreatic carcinoma;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;Patients;Pattern;pembrolizumab;Perfusion;Perioperative;Peripheral;peripheral blood;Peripheral Blood Lymphocyte;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;phase 2 study;Phase II Clinical Trials;Photosensitizing Agents;Population;predicting response;Primary Lesion;Primary Neoplasm;Process;programmed cell death ligand 1;programmed cell death protein 1;Progression-Free Survivals;PUVA Photochemotherapy;Quality of Life Assessment;radiomics;recruit;Regulatory T-Lymphocyte;Research;Residual Neoplasm;Resistance;response;Sampling;Signal Transduction;Skin Cancer;Skin Neoplasms;T-Cell Activation;T-Lymphocyte;Therapeutic;Toxic effect;tumor;tumor progression;Universities;Verteporfin;Work;X-Ray Computed Tomography

PROJECT_TITLE: Project 2: Intratumoral PDT Induces PDP-based Enhancement of PD-1 Inhibition in Pancreatic Carcinoma


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cardiovascular;Cerebrovascular;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Stroke

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Atrial fibrillation (AF) is the most common cardiac arrhythmia and a major cause of stroke. AF causes significant morbidity and mortality, and its prevalence is rising dramatically. We aim to leverage innovative computational tools and high-quality, extensive data (1.6 m patients, augmented with social determinants of health information) to improve the accuracy and equitably of stroke risk prediction. The work proposed here will use machine learning and artificial intelligence to identify novel clinical risk factors and social determinants of heath that impact AF risk and outcomes. This will provide better, more personalized, and equitable stroke risk stratification and prevention for patients with AF.

PI_NAMEs: REISINGER, RAQUEL  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Adult;Affect;American;Arrhythmia;Artificial Intelligence;artificial intelligence method;artificial intelligence model;Atrial Fibrillation;Awareness;Big Data;Blood;Blood coagulation;Blood flow;Brain;Cardiology;Caring;Cause of Death;Classification;Clinical;clinical risk;clinical training;Coagulation Process;comorbidity;Complex;computerized tools;Computing Methodologies;Confounding Factors (Epidemiology);Data;Data Set;Development;Diagnosis;Disparity;disparity reduction;Equity;Etiology;experience;explainable artificial intelligence;health care disparity;health data;health disparity;Health system;Heart Atrium;Hospital Costs;improved;Individual;innovation;Knowledge;large datasets;Machine Learning;machine learning method;Mathematics;Mentorship;Methods;model building;Modeling;Morbidity - disease rate;mortality;multidisciplinary;novel;Outcome;outcome prediction;patient subsets;Patients;Physicians;Population Heterogeneity;Prevalence;Prevention;Prevention therapy;Publishing;Research Personnel;Risk;Risk Factors;Risk Management;risk prediction;risk prediction model;risk stratification;Scientist;social;social health determinants;socioeconomics;standard of care;Stroke;Stroke prevention;stroke risk;synergism;therapy development;tool;Training;Travel;treatment guidelines;Universities;Utah;web app;Work

PROJECT_TITLE: Developing Explainable AI for Equitable Risk Stratification of Atrial Fibrillation and Stroke

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research

PI_NAMEs: ROUNDS, SHARON IRENE SMITH (contact)

PROJECT_TERMS: Address;Adopted;Affect;Area;Award;catalyst;Centers of Research Excellence;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communication;Communities;community based research;community collaboration;community engaged research;community engagement;Community Outreach;Consultations;COVID-19 pandemic;Data;Development;Diagnosis;Discipline;Disease;Electronics;Environment;Evaluation;Event;Evolution;experience;Extramural Activities;Faculty;Fostering;Funding;Generations;Goals;Grant;Health;Health Priorities;Health Promotion;Health Status;Healthcare;Hybrids;improved;innovation;Institution;inter-institutional;interdisciplinary collaboration;K-Series Research Career Programs;Lead;Letters;medically underserved;Mentors;Needs Assessment;Online Systems;Persons;Pilot Projects;Population;posters;Prevention approach;Process;programs;Public Health;Request for Applications;Research;Research Personnel;Review Committee;Rhode Island;Services;success;Surveys;symposium;synergism;Talents;translational approach;Translational Research;translational scientist;virtual

PROJECT_TITLE: Pilot Projects Program


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

PHR: Narrative Pancreatic cancer is a devastating disease with poor response to most therapies, including immunotherapy, which is the new hope for cancer management. Therefore, we propose a new treatment approach to overcome the major obstacle of non-responsiveness of pancreatic cancers to immunotherapy, by transforming non- responding, immunologically “cold” tumors, to “hot” responsive ones using red light activation of a drug already FDA approved with no serious reported toxicities. Combined with a novel real-time, high-resolution imaging system this strategy is expected to provide the ideal timing of immunotherapy drugs thus enhancing efficacy, reducing toxicities and expanding the immunotherapy eligible pancreatic cancer patient population (presently only 1-3%).

PI_NAMEs: HASAN, TAYYABA  (contact)

PROJECT_TERMS: 3-Dimensional;Abscopal effect;Animals;anti-PD-1;anti-PD-L1;anti-PD-L1 therapy;anti-PD1 therapy;anti-tumor immune response;Area;Autologous;Bilateral;Biological Markers;Blinded;Blood Vessels;cancer imaging;Categories;Cell Line;Cell Survival;checkpoint inhibition;Chemoresistance;chemotherapy;Clinical;Collaborations;Combination Drug Therapy;Combined Modality Therapy;cytokine;Data;design;Diameter;Dimensions;Disease;dosage;Dose;dosimetry;efficacy evaluation;Eligibility Determination;FDA approved;Fine needle aspiration biopsy;functional status;Future;Generations;Goals;Heterogeneity;high resolution imaging;Human;Image;image guided;imaging capabilities;imaging platform;imaging system;Immune;immune cell infiltrate;immune checkpoint blockade;immune resistance;Immune response;immune-related adverse events;Immunocompetent;immunogenic;immunogenic cell death;Immunologic Monitoring;Immunologics;immunoregulation;Immunotherapeutic agent;Immunotherapy;in vivo;innovation;insight;Intervention;KPC model;Light;Literature;Lymphocytic Infiltrate;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Metabolic;Microsatellite Instability;migration;Modeling;Molecular Target;Monitor;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Organoids;Outcome;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathologist;patient population;Patients;PD-1/PD-L1;pembrolizumab;Performance;Peripheral Blood Mononuclear Cell;Permeability;Pharmaceutical Preparations;pharmacologic;Phenotype;Photosensitizing Agents;point of care;Pre-Clinical Model;preclinical study;Process;PUVA Photochemotherapy;Radiation;Radiology Specialty;radioresistant;Receptor Protein-Tyrosine Kinases;Refractory;Reporting;Research;Resolution;response;statistics;Study models;subcutaneous;success;Survival Rate;synergism;Technology;Testing;Therapeutic;therapy design;therapy outcome;three-dimensional modeling;Time;tool;Toxic effect;treatment response;treatment strategy;Treatment-related toxicity;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Volume;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;Tyrosine Kinase Inhibitor;Validation;validation studies;Verteporfin;Visualization

PROJECT_TITLE: Project 3: Immune Checkpoint Inhibition Therapy Enhanced by Integrated Photodynamic Treatment and Image Guidance in Preclinical Models of Pancreatic Cancer


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: DALLAS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Autophagy is an important cell biological mechanism that cells use to restore energy supplies at time of starvation and to rid themselves of damaging content such as aggregated proteins, dysfunctional mitochondria or invading bacteria. Interruption of autophagy causes neuronal degeneration of neurons and photoreceptor cell dysfunction. The specific aims described in this proposal will explore the mechanisms boosting starvation-independent autophagy to address cellular challenges without the damage that can result from excessive autophagy.

PI_NAMEs: KRAMER, HELMUT J (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Acinus organ component;Address;Adult;age related;Alternative Splicing;analog;Autophagocytosis;Autophagosome;Bacteria;Biochemical;Biological;biological adaptation to stress;Calibration;Cell Physiology;Cells;Communicable Diseases;Cytoplasm;Data;Drosophila eye;Drug Targeting;Energy Supply;Eye;FRAP1 gene;Functional disorder;Genes;Genetic;Goals;Grant;Growth;inhibition of autophagy;interest;Interruption;Invaded;life span;Light;Link;Lysosomes;Macular degeneration;Malignant Neoplasms;Mammalian Cell;Measures;Membrane;Metabolic;Metabolic stress;Metabolism;Mitochondria;Modeling;Molecular;mTOR inhibition;mutant;Mutation;Nerve Degeneration;Nervous System;Neurons;Organelles;Oxidative Stress;Pathway interactions;pharmacologic;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;photoreceptor degeneration;Photoreceptors;Physiological;Physiology;Post-Translational Protein Processing;Process;protein activation;protein aggregation;protein function;Proteins;proteostasis;Quality Control;Research;response;Role;side effect;Signal Pathway;Signal Transduction;Sirolimus;Starvation;Stress;Testing;Time;Toxic effect;trafficking;Visual System;Work;Yeasts

PROJECT_TITLE: GENETICS OF ENDOCYTIC TRAFFICKING IN THE DROSOPHILA EYE

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Pediatric;Rare Diseases

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project narrative: This proposal uses Drosophila as a model organism to unravel novel regulatory mechanism by which, the evolutionarily conserved protocadherins Dachsous and Fat coordinate growth and patterning to create organs of proper size and shape. This work will have an impact on our understanding of congenital developmental disorders such as Maldergem and Hennekam syndromes, resulting from mutations affecting this signaling pathway.

PI_NAMEs: MISRA, JYOTI R. (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Address;Affect;Biological Models;Body System;Cadherins;Cell Adhesion Molecules;Cell membrane;Cytoplasmic Tail;Defect;Development;developmental disease;Drosophila genus;Endocytosis;Fatty acid glycerol esters;Genes;Growth;Hennekam syndrome;Image;Image Analysis;inhibitor;insight;Malignant Neoplasms;Mediating;model organism;Morphogenesis;morphogens;mutant;Mutation;Myosin ATPase;novel;Organ;Pathway interactions;Pattern;planar cell polarity;Play;quantitative imaging;Recycling;Regulation;Role;Shapes;Signal Pathway;Signal Transduction;trafficking;Van Maldergem syndrome;Work

PROJECT_TITLE: Regulation of tissue growth and morphogenesis by Fat cadherins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]