NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative Combination therapy, by targeting more than one oncoogenic pathways, is an effective strategy to combat drug resistance. This project will develop a critically needed approach for systematic discovery of combination therapeutic targets.

PI_NAMEs: TAN, KAI  (contact);TASIAN, SARAH KATHLEEN

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Acute Lymphocytic Leukemia;Algorithm Design;Algorithms;ATAC-seq;B-Cell Acute Lymphoblastic Leukemia;cancer cell;Cell Line;Cell Proliferation;Cell Survival;Chemicals;Child;ChIP-seq;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;combat;Combined Modality Therapy;Complex;Cytokine Receptors;Data;Development;Disease;disease heterogeneity;Drug resistance;Drug Targeting;Engineering;experimental study;follow-up;gene correction;gene network;gene regulatory network;Gene Targeting;Genes;Genetic;Genetic Medicine;Genetic Transcription;Genomics;Goals;high risk;Histones;Human;In Vitro;in vivo;Institution;kinase inhibitor;Knock-out;Malignant Neoplasms;Methods;Multiomic Data;Mutation;novel strategies;novel therapeutic intervention;Oncogene Deregulation;Oncogenes;Oncogenic;Outcome;Pathway interactions;patient derived xenograft model;Patients;Performance;Pharmaceutical Preparations;Philadelphia;phosphoproteomics;Phosphotransferases;Prevalence;protein expression;Proteome;Proteomics;rational design;Regulatory Pathway;Research;research clinical testing;Research Personnel;Resistance development;resistance mutation;Sampling;side effect;Signal Pathway;Signal Transduction;small molecule;small molecule inhibitor;synergism;Systems Biology;Testing;Therapeutic Intervention;therapeutic target;therapy development;Time;Toxic effect;transcriptome sequencing;Translational Research;young adult

PROJECT_TITLE: Towards rational design of combination therapeutic targets


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This application aims to characterize clinical specimens and preclinical models to determine the quantitative changes in protein abundance, protein modifications including phosphorylation, glycosylation, acetylation, ubiquitination, as well as protein interaction networks, to discover, verify, and confirm cancer protein targets associated with genomic alterations using state-of-the-art mass spectrometry based proteomic technologies. Understanding the molecular network in carcinogenesis is essential for the advancement of precision cancer medicine and development of a successful strategy to reduce cancer mortality.

PI_NAMEs: CHAN, DANIEL WANYUI;ZHANG, HUI  (contact)

PROGRAM_OFFICER_NAME: HILTKE, TARA

PROJECT_TERMS: Acceleration;Acetylation;Advanced Malignant Neoplasm;Bioinformatics;Biological;Biological Assay;Biometry;Cancer Biology;cancer diagnosis;cancer genomics;cancer therapy;cancer type;carcinogenesis;Center for Translational Science Activities;Clinical;clinical center;Clinical Research;cohort;Collaborations;Communities;Data;Data Analyses;data resource;Databases;Development;Diagnostic;DNA Sequence Alteration;experience;Future;Generations;Genes;Genome;genome analysis;genomic data;Genomics;glycoproteomics;glycosylation;Goals;Human;improved;Infrastructure;International;Knowledge;Label;Literature;Malignant Neoplasms;Mass Spectrum Analysis;Mission;Modeling;Molecular;mortality;multidisciplinary;multiple reaction monitoring;new technology;Normal tissue morphology;Organoids;Pathway interactions;patient derived xenograft model;Patients;phosphoproteomics;Phosphorylation;Pilot Projects;Play;Post-Translational Protein Processing;pre-clinical;Pre-Clinical Model;precision medicine;precision oncology;Process;prognostic;programs;protein complex;protein protein interaction;Proteins;proteogenomics;Proteome;Proteomics;Protocols documentation;Publishing;repository;Reproducibility;Research;Research Personnel;Resources;Role;Sampling;Scientist;Signal Pathway;Signal Transduction;Specimen;Standardization;success;technological innovation;Technology;technology development;technology platform;Therapeutic;Tissue Model;translational study;Translations;tumor;Tumor Tissue;Ubiquitination;Work

PROJECT_TITLE: Proteogenomic Characterization of Tumor Tissues and Preclinical Models with High Precision


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Cancer;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Although artificial intelligence (AI) based computer aided diagnosis systems have been shown to be useful in lung cancer screening and diagnosis, current radiology practice still suffers from (1) high rates of missed tumors and (2) imprecise lung nodule characterization (malignant vs. benign). The goal of this proposal is to create novel AI algorithms, called radiologist-centered AI, which tightly integrate in real time the radiologist's reading pattern and AI via an eye-tracking device and to demonstrate their improved efficacy via lung cancer screening experiments using low-dose CT scans. The outcome of this research will be a virtual cognitive assistant (VCA) for radiologists, truly actively collaborating with them instead of passively acting as second opinion tools or replacing them, and ultimately further reducing lung cancer-related deaths.

PI_NAMEs: BAGCI, ULAS  (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: Address;Adopted;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;attenuation;Benign;Black Box;calcification;Cancer Etiology;career;Cessation of life;Classification;Clinical;clinical decision-making;clinical diagnostics;Cognitive;Collaborations;Communication;computer human interaction;Computer-Assisted Diagnosis;cone-beam computed tomography;Cues;Data;deep learning;deep learning algorithm;deep reinforcement learning;design;Detection;Devices;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Procedure;educational atmosphere;efficacy evaluation;efficacy validation;Event;experience;experimental study;Feedback;flexibility;gaze;Glass;Goals;Human;Image;improved;inattention;insight;Intuition;Label;Learning;learning algorithm;Learning Module;learning network;Length;Location;low dose computed tomography;lung cancer screening;Lung Neoplasms;Lung nodule;Mainstreaming;Malignant - descriptor;Malignant neoplasm of lung;Measurement;Measures;men;Methodology;Modeling;mortality;Nodule;novel;Outcomes Research;Pattern;Pennsylvania;Performance;Phase;Probability;Process;radiologist;Radiology Specialty;Reading;Reproducibility;Research;sample fixation;satisfaction;Scanning;screening;Screening for cancer;Screening procedure;Second Opinions;Shapes;statistics;synergism;System;Techniques;technological innovation;Technology;Testing;Texture;Three-Dimensional Image;Time;tool;Training;tumor;United States;United States National Institutes of Health;Universities;Update;virtual;Visual attention;visual search;visual tracking;Visualization;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Radiologist-Centered Artificial Intelligence (RCAI) for Lung Cancer Screening and Diagnosis

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Sleep Research

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Chronic insufficient sleep during the school week is an ever present concern for children and adolescents with consequences particularly for attention and impulsivity. We currently lack an ability to mechanistically detect which child will be most vulnerable to insuffient sleep. To address this need, we propose an at-home sleep restriction experiment mirroring a school week, with neuroimaging, performance testing, and assays of neural arousal and circadian timing to untangle factors altering children with severe attention and impulsivity experience the consequences of sleep loss.

PI_NAMEs: SALETIN, JARED MEYER (contact)

PROGRAM_OFFICER_NAME: MACHLIN, LAURA STONER

PROJECT_TERMS: 13 year old;Academic achievement;Acute;Address;Adolescent;Adult;Affect;Arousal;Attention;Attention deficit hyperactivity disorder;Behavior;Behavioral Mechanisms;Biological Assay;Brain;brain behavior;brain dysfunction;Child;Childhood;Chronic;circadian;Circadian Rhythms;Classification;Clinic;Cognition;Cognitive;cognitive development;comparative;Complex;complex modeling;Data;Data Collection;design;Dimensions;Electroencephalography;Enrollment;Excessive Daytime Sleepiness;experience;experimental study;Functional Magnetic Resonance Imaging;Goals;Home;Image;Impairment;Impulsivity;inattention;indexing;Individual Differences;innovation;Machine Learning;Mediating;Mediator;Melatonin;memory recall;Mental Health;Methods;Middle School Student;Modeling;National Institute of Child Health and Human Development;National Institute of Mental Health;neural;Neurocognitive;Neurocognitive Deficit;neurocognitive test;Neurodevelopmental Disorder;neuroimaging;Outcome;Participant;Pattern;Performance;performance tests;Phase;Phenotype;Physiological;Physiology;Population;Predictive Factor;Psyche structure;resilience;Rest;Risk;Risk Factors;Sampling;Schools;simulation;Sleep;Sleep Deprivation;Sleep disturbances;sleep regulation;Study Subject;success;sustained attention;Symptoms;tau Proteins;Testing;Validation;Work;Youth

PROJECT_TITLE: Brain-behavior vulnerability to sleep loss in children: a dimensional study of attention and impulsivity

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative This cluster randomized trial is relevant to public health because it is the first implementation science study to develop and evaluate community-level working groups that aim to reduce household burning of plastic waste, a common exposure in rural low-income communities globally. Findings will be used to develop impactful community-driven public health actions in socially- and environmentally-disadvantaged communities in rural Guatemala. The project is relevant to the NIEHS mission because it fosters collaboration between research and community groups in the conduct of community-engaged research that aims to improve household and ambient air quality.

PI_NAMEs: SAIKAWA, ERI ;THOMPSON, LISA MARIE (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: 3-Dimensional;Address;Adoption;Adult;Age;Air;air monitoring;Air Pollutants;Air Pollution;ambient air pollution;Antimony;Area;Aromatic Polycyclic Hydrocarbons;Behavior;behavior change wheel;Behavior Therapy;Biological Markers;Biological Monitoring;Burn injury;Carbon Black;carcinogenicity;Central America;Cessation of life;Chemicals;Child;Cluster randomized trial;Collaborations;combustion product;Communities;community engaged research;cooking;Cookstove;Country;Developing Countries;Dissemination and Implementation;Effectiveness;Endocrine;Endocrine disruption;Environment;Environmental Hazards;Environmental Risk Factor;Evaluation;Exposure to;fine particles;Fire - disasters;Fostering;Future;Gases;Goals;Guatemala;hazard;Health;Health Hazards;health related quality of life;Household;Household Air Pollution;Human;implementation evaluation;implementation fidelity;implementation framework;implementation research;implementation science;improved;Incineration;Income;India;Infrastructure;innovation;International;Intervention;intervention program;Intervention Studies;Intervention Trial;Lead;low and middle-income countries;Low income;low income country;Maintenance;Measurable;Measures;member;Methodology;Methods;Mission;Modeling;Morbidity - disease rate;mortality;Motivation;National Institute of Environmental Health Sciences;neighborhood disadvantage;neurodevelopment;Peru;Petroleum;phthalates;Pilot Projects;Plastics;Policies;Policy Maker;pollutant;Population;Pregnant Women;premature;programs;Public Health;Random Allocation;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recycling;Refuse Disposal;Reporting;reproductive;reproductive function;Research;Research Personnel;Resource-limited setting;response;Rural;Rwanda;scale up;Smoke;social;solid fuel;Time;Tracer;trial design;uptake;urinary;Urine;volatile organic compound;Waste Management;wasting;Woman;Wood material;Work;working group

PROJECT_TITLE: Combustion of plastic waste and human health effects in Guatemala

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative Because the disease risk experienced by an individual is intimately tied to the evolutionary history of the population, a better understanding of the evolutionary forces that contribute to risk in modern day people will help improve clinical practices and personalized care. Using Native Hawaiians and Latinos as examples, the results of the research program proposed in this application will provide a better understanding of the demographic and adaptive histories, and elucidate the evolutionary etiology for elevated risks of diseases such as obesity, type-2 diabetes, and childhood leukemia, in these understudied populations.

PI_NAMEs: CHIANG, CHARLESTON  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Acceleration;Address;Alleles;Childhood Leukemia;clinical practice;Collaborations;Communities;Complex;Data Analyses;Development;Disease;disorder risk;Disparity;ethnic minority;Etiology;European;experience;Future;Genealogical Tree;Genetic;genetic analysis;genetic architecture;genetic epidemiology;genetic evolution;Genetic Research;genome resource;Genomics;Goals;health disparity;Heritability;Historical Demography;Human;improved;Individual;Latino Population;Medical Genetics;Meta-Analysis;method development;Modernization;Native Hawaiian;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Performance;personalized care;Persons;phenome;Phenotype;Polynesian;Population;Population Genetics;Population Heterogeneity;Positioning Attribute;pressure;programs;Recording of previous events;Research;Risk;Thinking;trait;Variant

PROJECT_TITLE: An evolutionary framework to elucidate and interpret the genetic architecture of complex traits in diverse populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Regional myocardial ischemia that leads to myocyte necrosis results in focal scar formation and a reduction in ventricular systolic function. Initially, myocardial and cellular remodeling serve to compensate for decreased systolic function by maintaining stroke volume and systemic perfusion. However, progressive remodeling can become injurious leading to further myocyte loss and decompensation. One pivotal factor that determines the degree to which remodeling occurs is the constitutive properties of the focal scar. Data suggest that there is a direct relationship between replacement scar stiffness and subsequent ventricular remodeling. Therefore, to improve outcomes for Veterans who suffer myocardial ischemia and infarction it is critical and necessary to define the cellular, molecular and biomechanical processes that govern and determine myocardial scar physical properties. Accordingly, we have focused our research efforts on defining the role of one novel cellular mechanism and its molecular determinants in myocardial ischemia induced scar formation.

PI_NAMEs: DELEON-PENNELL, KRISTINE Y (contact)

PROJECT_TERMS: 3-Dimensional;Anterior Descending Coronary Artery;Binding;Biomechanics;Cardiac;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell secretion;Cell Separation;Cells;Characteristics;Cicatrix;clinical practice;Clinical Treatment;Coculture Techniques;Collagen;Compensation;cytokine;cytotoxic;Data;Deposition;Echocardiography;Engraftment;experimental study;Extracellular Matrix;Extracellular Matrix Degradation;Fibroblasts;Fibrosis;Flow Cytometry;gain of function;Goals;Granzyme;healing;Health;Healthcare;Healthcare Systems;Heart;heart function;Hypertrophy;Immunohistochemistry;Impairment;improved;improved outcome;Infarction;Inflammatory;inhibitor;Injury;Ischemia;Knowledge;Left;Left Ventricular Dysfunction;Left Ventricular Remodeling;Left ventricular structure;Ligation;loss of function;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Mechanics;Mediating;Methods;migration;Mission;Molecular;mouse model;Mus;Muscle Cells;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;Necrosis;Necrosis Induction;novel;overexpression;PAR-1 Receptor;Paracrine Communication;Pathway interactions;Peptides;Perfusion;Personal Satisfaction;Phenotype;physical property;Physiological;Play;Population;preservation;Process;Production;Proliferating;Property;Proteomics;Research;Role;scaffold;Signal Transduction;Stress;Stroke Volume;Structure;T-Lymphocyte;Targeted Research;Testing;Tissue Inhibitor of Metalloproteinases;Translations;Ventricular;Ventricular Function;Ventricular Remodeling;Veterans

PROJECT_TITLE: Innate-like CD8+ T-cells facilitate in cardiac remodeling post-MI


ADMINISTERING_IC: AA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Heavy and frequent alcohol use remains a key public health concern, particularly among young adults. The proposed work will collect intensive momentary assessment data to examine associations between higher-risk alcohol use episodes (binge, high-intensity, blackout drinking) and multiple indices of next-day (post- intoxication) cognitive functioning. By identifying the acute impacts of varying levels of alcohol use intensity on next-day cognitive functioning as well as the day- and person-level characteristics that moderate these associations, our findings will have critical implications for the role of alcohol use on everyday cognitive functioning and highlight subgroups most in need of monitoring and early intervention.

PI_NAMEs: LINDEN-CARMICHAEL, ASHLEY NICOLE (contact);MOGLE, JACQUELINE

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Activities of Daily Living;Acute;Age;age group;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol measurement;alcohol risk;alcohol use disorder;Alcohols;Attention;Behavior;binge drinking;Brain;Buffers;Cannabis;Characteristics;Clinical;Cognition;Cognitive;cognitive function;Corpus Callosum;cost estimate;Data;Development;diaries;drinking;Early Intervention;Episodic memory;Event;executive function;experience;Female;hangover;Health;Heavy Drinking;high intensity drinking;high risk;Impaired cognition;indexing;Individual;Injury;Interruption;Intervention;Intoxication;Investigation;late life;Light;male;marijuana use;meetings;Memory;middle age;Monitor;Moods;morphometry;National Institute on Alcohol Abuse and Alcoholism;Outcome;Overdose;Patient Self-Report;Performance;Persons;Positioning Attribute;Prevention;Public Health;Reporting;Research;Risk;Role;Sampling;Severities;sex;sexual assault;Short-Term Memory;Signal Transduction;Sleep;Strategic Planning;Subgroup;substance use;Symptoms;Time;United States Substance Abuse and Mental Health Services Administration;Work;young adult

PROJECT_TITLE: An Ecological Investigation of Acute Next-Day Effects of Alcohol Use on Daily Cognitive Functioning

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: Project Narrative The overall goal of the MARC program at the University of Texas at San Antonio is to provide a comprehensive evidence-based training and support infrastructure that enables underrepresented undergraduates at UTSA to develop as biomedical and behavioral scientists who transition into, and complete, doctoral level training programs (e.g. Ph.D. or M.D./Ph.D.). Our trainees will contribute to public health by enhancing the creativity and productivity of the national biomedical and behavioral workforce. Those who follow an academic path will also help to diversify the nation’s universities as faculty who are more representative of all Americans.

PI_NAMEs: BAREA-RODRIGUEZ, EDWIN J (contact);CASSILL, AARON

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Admission activity;American;Award;Bachelor's Degree;Biology;Biomedical Engineering;Biomedical Research;career;CCL7 gene;Chemical Engineering;Chemistry;Computational Technique;Creativeness;Data;Development;disability;Disadvantaged;Diverse Workforce;Doctor of Philosophy;Educational workshop;Engineering;Ensure;ethnic minority population;Event;experience;Faculty;faculty research;Financial Support;Future;Goals;Government;Health;Industry;Institution;instructor;Interview;laboratory experience;Lead;Learning;Mathematics;Mentors;Modernization;novel strategies;peer networks;Persons;Philosophy;Physics;Play;Population;Positioning Attribute;programs;Psychology;recruit;Research;Research Training;Role;Schools;Science;Scientist;skills;student training;Students;summer research;symposium;Texas;Training;undergraduate student;Underrepresented Students;United States;Universities;Writing

PROJECT_TITLE: MARC at the University of Texas at San Antonio

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative The long-term goal of the Indiana Genomics Research Training Program for Data Scientists (INGEN4DS) is to increase the diversity of the genomics workforce by producing well-trained data scientists with genomics expertise. Training will be available for 8 students each year with the goal of these students joining the genomics workforce or matriculating into PhD programs in genomics. This goal will be accomplished by providing hands-on training with genomics data and participation in state-of-the-art genomics research in areas relevant to human health, such as cancer and rare genetic diseases.

PI_NAMEs: HUANG, KUN ;LIU, YUNLONG  (contact)

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Academia;Address;Admission activity;Area;Articulation;Bioinformatics;Biomedical Research;career;Career Choice;career development;cohort;college;Communication;Communities;Computational Biology;computing resources;Consultations;Data Analyses;Data Science;Data Scientist;Degree program;design;Development;Development Plans;disability;Doctor of Philosophy;Doctor's Degree;educational atmosphere;Employment;Enrollment;Ethics;Ethnic Population;expectation;experience;Faculty;faculty mentor;falls;Funding;genomic data;Genomics;Goals;Graduate Education;graduate school;hands on research;Health;Healthcare;Human;improved;Indiana;Individual;Industry;innovation;Institution;interest;Knowledge;Laboratories;Learning;Letters;Malignant Neoplasms;Master of Science;matriculation;member;Mentors;Mentorship;Methodology;Needs Assessment;Oral;Paper;Population Group;posters;Productivity;programs;public trust;Publications;Qualifying;rare genetic disorder;Readiness;Recommendation;recruit;Reporting;Reproducibility;Research;Research Project Grants;Research Training;responsible research conduct;Rotation;Safety;Science;science education;Scientist;Secure;Series;skills;social;STEM field;student participation;Students;success;symposium;Talents;Training;training data;Training Programs;Travel;undergraduate student;underrepresented minority student;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities;Writing


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Substance Misuse

ORG_CITY: Chicago

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Liver damage induced by chronic alcohol drinking (alcoholic liver disease, ALD) remains an important health problem in the United States and ranks among the major causes of morbidity and mortality in the world, and affects millions of patients worldwide each year, with no accepted therapy available to halt or reverse this process in humans. The recent preliminary studies in our laboratory demonstrated that chronic alcohol exposure is associated with increased expression of nicotinamide N-methyltransferase (NNMT) in the liver. Our further investigations suggest that NNMT inhibition confers protection against alcohol-induced fatty liver development, suggesting that NNMT plays a pathological role in the development of ALD and represent an ideal therapeutic target for the clinical intervention. In this proposal, we will utilize state of the art approaches to test our hypotheses using both cell culture and animal models.

PI_NAMEs: SONG, ZHENYUAN  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Affect;alcohol effect;alcohol exposure;alcohol prevention;Alcoholic Fatty Liver;Alcoholic Liver Diseases;Alcohols;Anabolism;Animal Model;Animals;arginase;Arginine;Cell Culture Techniques;Chronic;chronic alcohol ingestion;Cirrhosis;Clinical;CpG Islands;Cytoprotection;Data;Development;Diet;Disease;DNMT3a;Enzymes;Epigenetic Process;Essential Amino Acids;Event;Exposure to;Fatty Liver;FDA approved;Fibrosis;Gene Expression;Genes;Genetic;Health;Hepatic;Hepatocyte;Homeostasis;Human;improved;Inbred C57BL Mice;Individual;inhibitor;Injections;innovation;insight;Intervention;Investigation;knock-down;Knock-out;Knockout Mice;Laboratories;Lipids;Liver;liver development;Liver Failure;liver injury;LoxP-flanked allele;male;Mediating;Metabolic;Metabolism;metabolomics;Methionine Metabolism Pathway;Methylation;Mitochondria;Modeling;Morbidity - disease rate;mortality;Mus;Niacinamide;Nicotinamide N-Methyltransferase;novel;novel therapeutic intervention;old mice;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Performance;pharmacologic;Play;PPAR gamma;Preventive;Process;promoter;Protein Acetylation;Proteins;Reaction;Reporting;Research;response;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Sampling;Scheme;sensor;SIRT1 gene;small hairpin RNA;Steatohepatitis;targeted treatment;Testing;Therapeutic;therapeutic target;Transactivation;transmethylation;Treatment Efficacy;United States;Up-Regulation

PROJECT_TITLE: Hepatic Nicotinamide N-Methyltransferase (NNMT) as a Pathogenetic Mechanism and Therapeutic Target for Alcoholic Liver Disease

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_DEPT: PHARMACOLOGY

PHR: Narrative Streptococcus pyogenes (Group A Streptococcus, GAS) is responsible for human diseases of the respiratory tract, skin, connective tissues, and circulatory and immune systems. This proposal seeks to investigate the underlying mechanisms explaining how this bacterium suppresses effective immune responses. These experiments are important to determine whether inhibiting the bacterial immunosuppressive activities is a viable strategy to treat or prevent infections.

PI_NAMEs: FEDERLE, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Adherence;Aftercare;Agonist;attenuation;Bacteria;Binding;C Type Lectin Receptors;capsule;Cardiovascular system;Cause of Death;Cell Death;Cell Extracts;Cell Fractionation;Cells;Characteristics;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;Complement;Connective Tissue;cytokine;Data;Detection;Diglycerides;Disease;empowerment;Enzymes;Evaluation;experimental study;Fatty Acids;Gases;Gene Activation;Gene Cluster;Gene Expression Profile;Genes;genetic signature;Genome;High Pressure Liquid Chromatography;Host Defense;Human;human disease;Hyaluronan;Immune;Immune Cell Suppression;Immune response;Immune signaling;Immune system;Immunoglobulins;Immunosuppression;in vitro Model;in vivo;Infection;Infection prevention;Infectious Agent;Inflammatory;Inflammatory Response;inhibitor;innate immune function;Interleukin-6;Knock-out;Lectin;Link;Lipids;lipoteichoic acid;Location;Lymphocyte;Macrophage;Macrophage Activation;Mass Spectrum Analysis;Metabolic Pathway;Methods;microbial;Microbial Biofilms;Modeling;Molecular Weight;Muramidase;Mus;Myeloid Cells;Nasopharynx;novel;oxidation;Oxidative Phosphorylation;pathogen;Pathway interactions;Phagocytes;Phagocytosis;Physiological;Polymers;Production;Publishing;quorum sensing;recruit;Reporter;Reporting;Resistance;Respiratory Tract Diseases;response;RNA Interference;sialic acid binding Ig-like lectin;Sialic Acids;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Skin;skin disorder;Streptococcus pyogenes;Structure;Surface;System;Testing;Tissue Model;Tissues;Toll-like receptors;Tonsil;transcriptome sequencing;transcriptomic profiling;transcriptomics;translational proteomics;Upper respiratory tract;Validation;Virulence Factors;Western Blotting

PROJECT_TITLE: Macrophage Immunosuppression by Quorum-Induced Streptococcus pyogenes

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ORG_CITY: CHAPEL HILL

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: OVERALL Project Narrative This program project grant application focuses on the DNA tumor viruses, Epstein-Barr Virus (EBV), Kaposi Sarcoma-associated Herpesvirus (KSHV), and human papillomavirus (HPV) to identify the critical mechanisms by which these agents induce human cancer and deregulate cell growth. The projects will investigate how these viruses modulate cellular processes including cell signaling pathways, epigenetic networks, and immune evasion and will explore potential therapeutics to treat virus-associated cancers.

PI_NAMEs: DAMANIA, BLOSSOM A (contact);RAAB-TRAUB, NANCY JOAN

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Animal Model;Applications Grants;Awareness;Biochemical;Bioinformatics;Biological;Biological Assay;Biology;Biometry;Biostatistics Core;Cancer Etiology;carcinogenesis;Cell Culture Techniques;cell growth;Cell Physiology;Cells;ChIP-seq;co-infection;Cryoelectron Microscopy;Development;DNA Tumor Viruses;Electron Microscopy;Environment;Epigenetic Process;Epstein-Barr Virus Infections;equity, diversity, and inclusion;exosome;Experimental Models;extracellular vesicles;Fostering;gammaherpesvirus;Gene Expression;Genes;genetic approach;Genomics;Goals;graduate student;Herpesviridae;Human;human disease;Human Herpesvirus 4;Human Herpesvirus 8;Human Papillomavirus;Immune Evasion;Immune response;Immune signaling;Immunity;In Vitro;in vivo Model;Individual;innovation;Integration Host Factors;Investigation;Knowledge;Laboratories;Life Cycle Stages;Link;Malignant Neoplasms;Mediating;Messenger RNA;Methodology;MicroRNAs;Molecular;Neoplasm Metastasis;neoplastic cell;new therapeutic target;next generation sequencing;novel;novel therapeutics;Oncogenic;Oncogenic Viruses;oncology program;Pathway interactions;Photometry;Population;Postdoctoral Fellow;primary effusion lymphoma;Process;Program Research Project Grants;programs;Property;Research;Research Personnel;RNA;Role;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Structure;System;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Training;tumor;tumor microenvironment;tumorigenesis;Untranslated RNA;Viral;Viral Genes;Viral Pathogenesis;Viral Proteins;Virus;virus related cancer

PROJECT_TITLE: Viral Oncogenesis, Latency, and Replication


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Pediatric;Rare Diseases

PHR: Project 1 Project Narrative Project 1 continues to explore the biology of gammaherpesviruses and will probe the role of extracellular vesicles or exosomes in viral carcinogenesis. We will look at single extracellular vesicles by super resolution microscopy and cryo EM, and explore novel treatment approaches.

PI_NAMEs: DITTMER, DIRK P (contact)

PROJECT_TERMS: Adult;Affect;Africa South of the Sahara;analytical tool;Antineoplastic Agents;Biological Assay;Biology;Blood Vessels;Burkitt Lymphoma;cancer therapy;CD81 gene;Cells;chemotherapy;Child;Childhood;Circulation;Clinical;clinical infrastructure;clinically significant;Complement;Cryoelectron Microscopy;curative treatments;Cytotoxic Chemotherapy;Data;delivery vehicle;Doxorubicin;Drug Delivery Systems;Endothelium;epidemiologic data;Epstein-Barr Virus Infections;exosome;Exposure to;extracellular vesicles;Foundations;Funding;Future;gammaherpesvirus;Grant;High Dose Chemotherapy;Human;Human Herpesvirus 4;Human Herpesvirus 8;Human Papilloma Virus Vaccination;Image;in vivo;Individual;Infection;Infrastructure;Kaposi Sarcoma;Liposomal Doxorubicin;LMP1;lymph nodes;lymphatic vessel;Lymphoma;Lymphomagenesis;Lytic;Malignant Childhood Neoplasm;Malignant Neoplasms;MicroRNAs;Molecular;novel;novel marker;Paclitaxel;particle;Pathogenesis;Persons;Phase I Clinical Trials;Plasma;Population;Process;programs;Puberty;Publishing;Role;standard of care;Structure;superresolution microscopy;Testing;therapeutic evaluation;Time;tumor;tumor microenvironment;tumorigenesis;vaccine delivery;Vaccines;Viral;Viral Cancer;viral carcinogenesis;Viral Genome;Virion;Virus;Visualization

PROJECT_TITLE: Modulation of tumorigenesis by viral exosomes


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Rare Diseases;Women's Health Research

PHR: Project 2: Project Narrative A subset of HPV types are the causative agents of cervical cancer and are also associated with an increasing number of oropharyngeal squamous carcinomas (OSCC). EBV and KSHV are also found in the oral cavity and cause oral cancers. Similar to HPV, EBV and KSHV link their replication cycles to epithelial differentiation. Our studies focus on the influence of RNA molecules (R-loops and long non-coding RNAs) in the life cycle of HPV as well as KSHV and EBV in the oral epithelium and their effects on viral pathogenesis.

PI_NAMEs: MOODY, CARY A (contact)

PROJECT_TERMS: Affect;Architecture;carcinogenesis;cell type;Cells;Cellular biology;Chromatin;Chromosomes;Data;Development;differential expression;DNA;DNA biosynthesis;DNA Damage;DNA Tumor Viruses;Environment;Epithelial Cells;Epithelium;Exhibits;Future;Gene Expression;Genetic Transcription;Genomic Instability;Goals;Herpesviridae;high risk;High-Throughput Nucleotide Sequencing;HPV-High Risk;Human;Human Herpesvirus 4;Human Herpesvirus 8;Human papilloma virus 31;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Hybrids;Infection;insight;keratinocyte;Knowledge;Lesion;Life Cycle Stages;Link;Location;low and middle-income countries;Lytic Phase;lytic replication;Lytic Virus;malignant mouth neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Modification;new therapeutic target;novel strategies;Oncogenic Viruses;Oncoproteins;Oral;Oral cavity;oral cavity epithelium;Oropharyngeal;Oropharyngeal Squamous Cell Carcinoma;overexpression;Pathogenesis;Pathway interactions;premalignant;Production;Productivity;programs;Proliferating;Regulation;replication stress;RNA;Role;Saliva;Source;Squamous cell carcinoma;Stratified Epithelium;Subcellular Anatomy;Testing;therapeutic development;transcriptome;transmission process;tumorigenesis;Undifferentiated;Untranslated RNA;Viral;viral DNA;Viral Genome;Viral Pathogenesis;Virion;Virus;virus host interaction;virus related cancer;Virus Replication;Work

PROJECT_TITLE: Viral-host interactions that influence the life cycle of DNA tumor viruses


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Serious Mental Illness;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: MILWAUKEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN MILWAUKEE

ORG_STATE: WI

PHR: PROJECT NARRATIVE Identifying youth victims of violence most at risk for long-term post-traumatic distress is a pressing public health problem. This work seeks to identify dysregulation in neural circuitry supporting cognitive and affective processes two weeks after victimization predicts PTSD and other post-trauma symptom twelve months later. These data will advance our understanding of neurobiological factors associated with vulnerability to specific trauma-related pathology and provide an important step toward identifying appropriate early interventions in the wake of violence victimization.

PI_NAMEs: LARSON, CHRISTINE L (contact);LEVAS, MICHAEL N

PROGRAM_OFFICER_NAME: BORJA, SUSAN EILEEN

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Adult;Affect;Affective;Age;aged;Amygdaloid structure;Anxiety;Behavior;Behavioral;Biological Markers;Brain;brain health;child and adolescent victimization;Chronic Post Traumatic Stress Disorder;clinical care;Cognitive;cognitive control;cognitive function;Communities;comorbid depression;Complement;Data;Development;Dimensions;Discrimination;Distress;Early Intervention;Early-life trauma;Elements;emotion regulation;emotional functioning;Environment;Event;Exhibits;Family;follow-up;Functional disorder;Genetic;Goals;Health;high risk;Hormonal;Impairment;improved;Individual;injured;innovation;Intervention;Knowledge;Life;life span;Link;Machine Learning;Measures;Mental Depression;Mental disorders;Mental Health;multidisciplinary;neighborhood disadvantage;Neighborhoods;neural;neural circuit;neurobehavioral;Neurobiology;neuroimaging;Outcome;Parents;Pathology;Patient Self-Report;Pattern;Pediatric Hospitals;Performance;physical assault;post-trauma;Post-Traumatic Stress Disorders;Predictive Factor;predictive marker;preventive intervention;Process;programs;prospective;Psychopathology;Public Health;Quality of life;recruit;reduce symptoms;Reporting;Research;resilience;Risk;Risk Factors;Risk Marker;risk prediction;Sampling;Schools;sexual assault;Signal Transduction;social;Social Functioning;socioenvironmental factor;Specific qualifier value;stress symptom;Substance abuse problem;Suicide attempt;Symptoms;System;Time;Translating;Trauma;trauma exposure;trauma symptom;Traumatic injury;traumatic stress;Victimization;Violence;violence exposure;violence victimization;Wisconsin;Work;Youth;youth violence

PROJECT_TITLE: Acute predictors of long-term post-trauma outcomes in youth victims of violence


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PHR: Project 3 Project Narrative In this application, we propose to explore how the oncogenic gammaherpesviruses, KSHV and EBV, modulate host immune pathways and contribute to oncogenesis. Investigating the various mechanisms involved in modulation of host immunity and oncogenesis by these tumor viruses will inform our understanding of the biology and pathogenesis of these viruses. Our findings will also pave the way for future therapies to treat virus-associated cancers.

PI_NAMEs: DAMANIA, BLOSSOM A (contact)

PROJECT_TERMS: Adenosine;Adenosine Triphosphate;Apyrase;ATP phosphohydrolase;Automobile Driving;B-Cell Lymphomas;B-Lymphocytes;Biology;Cancer Burden;cancer cell;Cell Proliferation;Cells;Cellular biology;Cervix Carcinoma;co-infection;Code;Development;DNA Tumor Viruses;DNA Viruses;dsRNA adenosine deaminase;EBV reactivation from latency;ecto-nucleotidase;Endothelium;Epithelium;Epstein-Barr pathogenesis;Epstein-Barr Virus-Related Lymphoma;Equilibrium;extracellular;Future;gammaherpesvirus;Generations;Growth;Human;Human Herpesvirus 4;Human Herpesvirus 8;Human Papillomavirus;Immune;immune activation;Immune response;Immune signaling;Immunity;in vivo;infected B cell;Inflammatory;Inflammatory Response;Kaposi Sarcoma;Life Cycle Stages;Lymphoma;Lymphomagenesis;Lymphoproliferative Disorders;Lytic;Malignant Neoplasms;malignant oropharynx neoplasm;malignant stomach neoplasm;Mediating;Mitochondrial RNA;Nasopharynx Carcinoma;Oncogenic;Oncogenic Viruses;Oxidative Phosphorylation;Pathway interactions;primary effusion lymphoma;Proteins;Purines;reactivation from latency;Reporting;RNA;Role;Satellite Viruses;Signal Pathway;Signal Transduction;Stimulus;Transforming Growth Factor beta;tumorigenesis;Tumorigenicity;Viral;Viral Pathogenesis;Virus;Virus Diseases;virus related cancer

PROJECT_TITLE: Gammaherpesviral interactions with the host cell


FUNDING_MECHANISM: OTHERS

ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Traumatic brain injury (TBI) impacts 1.7 million people per year in the United States5. TBI often results in chronic changes in cognition and mood that we cannot effectively treat3,4. The likelihood of sustaining a brain injury is increased for military personnel. 15-20% of soldiers serving in Iraq and Afghanistan experienced a TBI during deployment6. The proposed research investigates the brain mechanisms contributing to persistent cognitive deficits following frontal TBI. Preclinical models are necessary to employ invasive techniques to measure, manipulate, and restore brain activity that will ultimately inform human TBI research. The current proposal aligns with the VA’s mission to identify clinically relevant biomarkers used to predict patient outcomes and assess treatments for Veterans. New treatment options follow a precision medicine approach: targeting a specific brain area/function that is individualized based on each unique trauma. This research tests the effectiveness of precision stimulation to remediate cognitive behaviors after TBI by restoring brain activity through neuroplasticity.

PI_NAMEs: KOLOSKI, MIRANDA FRANCOEUR (contact)

PROJECT_TERMS: Acute;Address;Afghanistan;Animal Model;Animals;Anxiety;Area;associated symptom;Attentional deficit;Automobile Driving;Axon;Behavior;Behavioral;behavioral impairment;Behavioral inhibition;Bilateral;Biological;Biological Markers;Brain;brain based;Brain Concussion;Brain Injuries;Brain region;Central Nervous System;Chronic;Clinical Research;clinically relevant;Cognition;Cognitive;Cognitive deficits;cognitive function;Cognitive remediation;cohort;Communication;controlled cortical impact;Contusions;Corpus striatum structure;Coupling;cranium;debilitating symptom;Decision Making;Discrimination;Effectiveness;effectiveness testing;Electric Stimulation;electrical potential;Encephalitis;experience;flexibility;Frequencies;Goals;gray matter;Hemorrhage;Human;Impairment;improved;Impulsivity;Inflammation;Inflammatory;Injury;insight;Interruption;Intervention;Iraq;Knowledge;Lateral;Learning;Location;Measures;Mediating;Mental Depression;Mental disorders;Methods;Military Personnel;Mission;Modeling;Molecular;Mood Disorders;Moods;neural;Neurobehavioral Manifestations;neuromechanism;Neuronal Plasticity;neurophysiology;neuroregulation;new therapeutic target;novel;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Patients;Pattern;Periodicals;Periodicity;persistent symptom;Persons;pre-clinical;Pre-Clinical Model;precision medicine;Preclinical Testing;Prefrontal Cortex;Procedures;psychiatric symptom;Psychological reinforcement;Rattus;remediation;Reproducibility;Research;Reversal Learning;Rewards;Risk;Rodent;Rodent Model;Role;Running;Severities;Soldier;Structure;Symptoms;Techniques;Testing;Therapeutic Intervention;Training;translational potential;Trauma;Traumatic Brain Injury;Traumatic Brain Injury recovery;United States;Update;Veterans;white matter

PROJECT_TITLE: Molecular and neural mechanisms associated with injury and recovery from traumatic brain injury


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Infectious Diseases

PHR: Project 4 Project Narrative The goal of this research program is to determine whether Epstein Barr virus alters the growth or cellular expression of HPV infected cells through transfer of EBV proteins or BART noncoding RNAs. The BART RNAs, which are the most abundantly expressed viral genes in vivo, can be processed to express 44 miRNAs or are intricately and distinctly spliced into multiple long noncoding (lnc) RNAs. This proposal will also assess the effects of the BART RNAs on cell growth properties and determine how the lnc RNAs affect cellular expression.

PI_NAMEs: RAAB-TRAUB, NANCY JOAN (contact)

PROJECT_TERMS: Affect;Agar;Alternative Splicing;Biological Assay;Biological Process;bisulfite sequencing;Bromodeoxyuridine;cell growth;Cell Line;Cell Physiology;Cell secretion;Cells;ChIP-seq;co-infection;Coculture Techniques;Collaborations;CpG Islands;Deposition;Development;DNA;Epithelial Cells;Epithelium;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Exons;exosome;experimental study;extracellular vesicles;Gene Cluster;Gene Expression;Gene Silencing;Genes;Genetic Transcription;Genomics;Goals;Growth;Human Herpesvirus 4;Human papilloma virus infection;Human Papillomavirus;Immunoprecipitation;In Vitro;in vivo;Incidence;Infection;keratinocyte;LMP1;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Membrane Proteins;Methylation;MicroRNAs;Migration Assay;mRNA sequencing;Mus;NOD/SCID mouse;novel strategies;Nuclear Pore Complex;Oncogenic;opportunistic pathogen;Oral;oral HPV;oral infection;Oropharyngeal;Pathway interactions;permissiveness;persistent EBV infection;Population;Process;Production;programs;promoter;Property;Protein Isoforms;Protein Secretion;Proteins;Research;RNA;RNA Splicing;Signal Pathway;Small RNA;Stains;Structure;Testing;Throat Cancer;Transcript;transcriptome sequencing;transforming virus;tumor;tumorigenesis;Ubiquitination;Untranslated RNA;uptake;Viral;Viral Genes;viral genomics;Viral Oncogene;Viral Proteins;Virus;Virus Diseases;virus related cancer;Visualization;Western Blotting;whole genome;Xenograft procedure

PROJECT_TITLE: Tumorigenesis by the Epstein Barr Virus


NIH_SPENDING_CATS: Cancer;HIV/AIDS

PHR: Core A: Administrative Core Project Narrative The Administrative Core (Core A) will provide the structure for the overall program and will facilitate interactions between the four Projects and the two other Cores. It will provide scientific leadership, facilitate scientific exchange between all components in the program and provide fiscal support for all projects and cores. In summary, Core A will promote programmatic interactions and foster the exchange of information and reagents to ensure all aspects of a successful and productive program project.

PROJECT_TITLE: Administrative Core A


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Infectious Diseases

PHR: Core B: Vironomics and Biostatistics Core Project Narrative Core B, Vironomics and Biostatistics, provides bioinformatics support for all projects and specializes in systems and high-throughput biology. Both analysis and “wet-lab” sequence generation are combined in one unit to maximize efficiency.

PROJECT_TERMS: 2019-nCoV;Bioinformatics;bioinformatics infrastructure;Biological Assay;Biology;Biometry;Biopsy;Biostatistics Core;Cell Line;Cell Lineage;Cells;ChIP-seq;Clinical;Comprehensive Cancer Center;Cytomegalovirus;Data Security;data sharing;Dedications;distinguished professor;DNA;Ensure;Evolution;exome sequencing;extracellular vesicles;FAIRE sequencing;Formalin;Funding;Generations;Genetic Transcription;Genome;Grant;Guidelines;Herpesviridae;Herpesvirus 1;Hour;Human;Human Herpesvirus 4;Human Herpesvirus 8;Human Papillomavirus;Hybridization Array;Infrastructure;innovation;instrument;Ions;Lead;Lesion;Life Cycle Stages;Linux;Location;Malignant Neoplasms;Maps;member;Messenger RNA;MicroRNAs;miRNA expression profiling;Molecular Biology;Molecular Virology;mRNA sequencing;nanopore;next generation;next generation sequencing;North Carolina;novel;Oncogenic Viruses;Open Reading Frames;performance site;Plasma;Policies;Program Research Project Grants;Research Personnel;Resources;RNA;RNA Splicing;Saliva;Sampling;sequencing platform;Services;single cell analysis;single cell sequencing;single-cell RNA sequencing;statistics;System;Technology;technology validation;Time;tissue fixing;transcriptome sequencing;tumor;Tumor-Derived;tumorigenesis;United States National Institutes of Health;Untranslated RNA;Viral;viral genomics;Viral Pathogenesis;virology;Virus;whole genome

PROJECT_TITLE: Vironomics and Biostatistics Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases

PHR: Core C: EM and Mass Photometry Structural Core Project Narrative Core C, Electron Microscopy and Mass Photometry provides support for all projects in the area of structural biology including EM, cryoEM, Mass Photometry and immuno-EM. Both routine analysis and long-range in- depth studies are conducted with members of the program project.

PI_NAMEs: GRIFFITH, JACK D (contact)

PROJECT_TERMS: Antibodies;Area;Base Pairing;Binding;Binding Proteins;Binding Sites;Biochemical;Biological Assay;Cells;Chromatin Loop;Collaborations;Complex;Comprehensive Cancer Center;Cryoelectron Microscopy;density;detection assay;dimer;DNA;DNA replication fork;DNA-Directed RNA Polymerase;Electron Microscopy;exosome;experimental study;extracellular vesicles;Funding;Gelshift Analysis;Gene Expression;Genetic Recombination;Genetic Transcription;Genomic DNA;Gold;Grant;Herpesviridae;Herpesvirus 1;Human Herpesvirus 4;Human Herpesvirus 8;Human Papillomavirus;Hybrids;Image;Immunology procedure;Immunoprecipitation;In Vitro;Individual;Laboratories;Location;Maps;Measures;member;Metals;Methods;Microtomy;Modeling;Molecular Weight;monomer;nano;Nature;Negative Staining;North Carolina;novel;novel strategies;oncology program;particle;performance site;Photometry;Preparation;Productivity;Program Research Project Grants;programs;protein complex;Proteins;recombinase;Research Project Grants;RNA;Sampling;Side;single molecule;Specificity;structural biology;Techniques;Technology;Terminal Repeat Sequences;Transcript;Transmission Electron Microscopy;tumorigenesis;Viral;viral DNA;Virus;Virus Replication;Visualization;Work

PROJECT_TITLE: Structural Core


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Autism;Brain Disorders;Complementary and Integrative Health;Dietary Supplements;Disability Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Nutrition;Pediatric;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT: The potential harm of folate excess and underlying molecular mechanisms warrant careful exploration given that all the pregnant women are recommended to take prenatal folic acid supplement and US is a country with mandatory folic acid grain fortification. If this finding is further confirmed, optimizing maternal folate levels preconception and during pregnancy holds promise to improve child neuro-developmental outcomes, in addition to other known beneficial health effects.

PI_NAMEs: WANG, XIAOBIN ;XIE, HEHUANG  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Adipocytes;Affect;Anxiety;ASD patient;Attention;autism spectrum disorder;Biological Process;Birth;bisulfite sequencing;Blood specimen;Boston;case control;Cell Differentiation process;Child;Clinical;cohort;Cohort Studies;comorbidity;Conceptions;cost effectiveness;Country;Coupled;Data;Defect;demethylation;design;Development;Developmental Disabilities;disorder risk;DNA biosynthesis;DNA Methylation;Drosophila genus;Environmental Exposure;Epidemic;Family;FMR1 gene;Folic Acid;Folic Acid Deficiency;Folic acid fortification;folic acid supplementation;Fortification;Fragile X Syndrome;Frequencies;frontal lobe;Funding;Genes;genome-wide;Genomic Instability;Grain;Health;Human;improved;in utero;Individual;insight;Intake;Investigation;Laboratory Study;Link;Measures;Messenger RNA;Metabolism;Methodology;Methylation;Micronutrients;Modification;Molecular;mouse model;Multivitamin;Mus;National Health and Nutrition Examination Survey;nerve stem cell;novel;Outcome;overexpression;Pattern;peripheral blood;Phosphorylation;Plasma;polysome profiling;postnatal development;Pregnancy;Pregnant Women;prenatal;Prevalence;prospective;protein expression;Protein Overexpression;Proteins;Public Health;public health relevance;Reader;Recommendation;Risk;RNA;RNA methylation;Role;Sampling;Shapes;Site;Societies;stem cell proliferation;Supplementation;Testing;Tissues;toxicant;trait;Transcript;Transcriptional Regulation;transcriptome;Translations;Umbilical Cord Blood;United States National Institutes of Health;Untranslated RNA;Variant;Vitamin B Complex

PROJECT_TITLE: Functional RNA Modifications, Micronutrient Exposure, Developmental Disabilities


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Heart Disease;Hypertension;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE There is a critical need to develop effective strategies to mitigate the cardiotoxic effects of breast cancer therapies and to improve cardiovascular health in breast cancer survivors. We propose a randomized controlled trial of intensive systolic blood pressure (SBP) control (goal SBP <120 mm Hg) versus standard SBP control (goal SBP <140 mm Hg) among 130 patients with breast cancer at risk for cardiotoxicity due to hypertension and treatment with cardiotoxic cancer therapies. Results will: 1) establish critical data to inform clinical implementation of an intensive SBP control strategy for patients with breast cancer at risk for cardiotoxicity, 2) provide functional and mechanistic insights into the effects of intensive SBP control on mitigation of cardiotoxicity risk, and 3) guide future cardio-oncology practice recommendations on the role of HTN management to improve cardiovascular health in patients with cancer.

PI_NAMEs: YU, ANTHONY FRANCIS (contact)

PROGRAM_OFFICER_NAME: DIMOND, EILEEN

PROJECT_TERMS: Address;Adrenergic beta-Antagonists;Adverse event;Algorithms;Angiotensin-Converting Enzyme Inhibitors;Anthracycline;Attenuated;Biological Markers;Blood Pressure;blood pressure control;Breast Cancer survivor;Breast Cancer therapy;Breast Cancer Treatment;cancer care;cancer initiation;cancer therapy;Cardiac Myocytes;cardioprotection;cardiorespiratory fitness;Cardiotoxicity;Cardiovascular Diseases;cardiovascular health;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;cell free DNA;Cessation of life;chemotherapy;circulating biomarkers;Clinical;clinical implementation;clinically significant;comorbidity;CXCL10 gene;Cyclic GMP;Data;Development;efficacy evaluation;Epidermal Growth Factor Receptor;Event;Exclusion;Frequencies;Future;Goals;Guidelines;Heart failure;high risk;Human;Hypertension;hypertension control;hypertension treatment;Image;Impairment;improved;Inflammation;insight;Intervention;Investigation;Knowledge;Left Ventricular Ejection Fraction;Long-Term Survivors;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Modeling;modifiable risk;Morbidity - disease rate;mortality;myocardial injury;Myocarditis;Natriuretic Peptides;Oncology;Outcome;Oxygen Consumption;Patient Outcomes Assessments;Patients;Play;prevent;primary outcome;Prognostic Marker;Quality of life;Random Allocation;randomized trial;Randomized, Controlled Trials;Recommendation;Risk;Risk Factors;Role;Safety;secondary outcome;standard care;Stimulator of Interferon Genes;Stress;Stroke;targeted agent;targeted treatment;therapy development;Toxic effect;treatment response;treatment trial;trial design;Troponin;Woman;women's prevention;Work

PROJECT_TITLE: Intensive Blood Pressure Control During Cardiotoxic Breast Cancer Treatment (PROTECT) Trial

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: Newark

ORG_DEPT: PSYCHIATRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative The results of this project will enhance our understanding of the causes and health-related consequences of drinking from adolescence through early midlife. The results may inform the development of more effective, tailored programs of prevention and intervention.

PI_NAMEs: DICK, DANIELLE M;SALVATORE, JESSICA E (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Address;Adolescence;Adolescent;Age;Alcohol abuse;alcohol consequences;Alcohol consumption;alcohol effect;alcohol misuse;Behavior;biobank;Calendar;career;Clinical;cohort;Communication;Creativeness;Data;Dependence;design;Development;Diagnostic;DNA;drinking;early adolescence;Education;Employment;Environment;Environmental Risk Factor;Epidemiology;Etiology;Event;experience;Family;Female;Finland;Foundations;gene environment interaction;General Population;Genes;genetic epidemiology;Genetic Risk;Goals;Grant;Health;Individual;informant;Infrastructure;innovation;Intervention;Interview;Knowledge;knowledge base;Laboratories;late life;Life;life history;life span;Longitudinal Studies;Measures;middle age;Modernization;Molecular Genetics;National Institute on Alcohol Abuse and Alcoholism;National Longitudinal Survey of Adolescent to Adult Health;Nature;Neurocognitive;Outcome;Parents;Participant;Patient Self-Report;Pattern;peer;Personal Satisfaction;Personality;Persons;Phase;physical conditioning;Play;population based;Predisposition;Prevention program;programs;prospective;protective factors;Public Health;recruit;Registries;Research;Risk Factors;Role;Salivary;Sampling;satisfaction;Siblings;Sleep;Spouses;substance use;Surveys;Testing;theories;Time;Translating;Twin Multiple Birth;Twin Studies;Variant;Work;young adult

PROJECT_TITLE: The development of alcohol misuse and related problems from adolescence to early midlife

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cancer;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative Magnetic resonance (MR) is a safe method for brain imaging that does not rely upon ionizing radiation. We will develop MR detection of HDO generated from metabolism of [2H7]glucose as a sensitive biomarker of glucose uptake and metabolism in the brain. Our overall goal is to develop a robust, MR based metabolic imaging paradigm for detection of cerebral glucose utilization that can be applied to all areas of brain research and to clinical targets of brain dysfunction.

PI_NAMEs: BANKSON, JAMES A;KODIBAGKAR, VIKRAM D.;MERRITT, MATTHEW E (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: Acceleration;Address;Agreement;Animal Model;Appearance;Area;Basic Science;Biochemistry;Biological;Biological Markers;Blood Vessels;Brain;brain dysfunction;Brain imaging;brain metabolism;brain research;Calibration;Cancer Detection;Cancer Model;Carbon;Cerebrum;Chemical Shift Imaging;Chemicals;Childhood;Citric Acid Cycle;Clinical;clinical diagnosis;Cognition;Complex;Consumption;Contrast Media;Data;Deoxyglucose;Detection;detection method;Deuterium;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;dosage;Dose;Electromagnetic Energy;experimental study;Face;fluorodeoxyglucose positron emission tomography;Functional disorder;Future;Generations;Glucose;glucose metabolism;Glucose tolerance test;glucose uptake;Glutamates;Glutamine;Glycolysis;Goals;Guidelines;Hour;Hybrids;Image;imaging agent;imaging approach;imaging modality;improved;in vivo;inhibitor;Injections;insight;insulin sensitivity;interest;Intracellular Space;Ionizing radiation;Longitudinal Studies;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Metabolic;metabolic imaging;Metabolism;Methods;Modeling;multiparametric imaging;Neurosciences;Noise;oxidation;Pediatric Oncology;Peripheral;Population;Positron-Emission Tomography;Production;Radiation exposure;reconstruction;Relaxation;Reporter;Reporting;Research;Resolution;response;Sampling;Science;Signal Transduction;Site;Specificity;spectroscopic imaging;Sprague-Dawley Rats;success;targeted imaging;Techniques;Testing;Time;Tissues;Tracer;tumor;Validation;Work

PROJECT_TITLE: HDO Imaging is a Quantitative Marker of Cerebral Glucose Oxidation

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

ORG_STATE: OH

PHR: Project Narrative This project is aimed to determine the neuropharmacological effects of compounds acting on glutamate transporters for the attenuation of alcohol consumption and alcohol relapse behaviors. The innovative features of this proposal are to reveal the pharmacological actions of promising novel beta-lactams to determine their pharmacological and therapeutic effects for the treatment of alcohol dependence. By the end of the project, we anticipate identifying at least one advanced molecule that possesses the drug-like properties and pharmacokinetic profile needed to qualify for advancement to development.

PI_NAMEs: ABOU-GHARBIA, MAGID ;SARI, YOUSSEF  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol preferring rats;alcohol relapse;alcohol seeking behavior;alcoholism therapy;Alcohols;analog;Antibiotics;Antiinflammatory Effect;antiporter;Attenuated;attenuation;Behavior;beta-Hydroxybutyrate;beta-Lactamase;beta-Lactams;Biological Assay;Biological Markers;Brain region;brain reward regions;Ceftriaxone;Chemicals;Chronic;Clavulanic Acids;Clinical;Clinical Trials;Cocaine;Consumption;Cystine;Data;Dependence;Development;Dose;drinking behavior;drug action;Drug Addiction;Drug Kinetics;drug of abuse;Effectiveness;Ethanol;Ethanol dependence;Excitatory Amino Acid Transporter 1;Excitatory Amino Acid Transporter 2;extracellular;FDA approved;Female;Glutamate Transporter;Glutamates;Goals;Homeostasis;In Vitro;in vivo;inflammatory marker;inhibitor;Injections;innovation;Intake;Lactams;Lead;Link;Lipids;lipophilicity;Liver;male;Medial;Membrane;Monobactams;neurochemistry;neuroinflammation;Neuropharmacology;neuropsychiatric disorder;novel;novel therapeutics;Nucleus Accumbens;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacologic Actions;PPAR alpha;preclinical study;Prefrontal Cortex;Procedures;Property;Proteins;Qualifying;Rattus;Relapse;scaffold;Therapeutic Effect;transmission process;Up-Regulation;uptake;Work

PROJECT_TITLE: Novel GLT-1 activators for the treatment of alcohol dependence: preclinical studies

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: PROJECT NARRATIVE The proposed Translational Coordination and Dissemination Center (TCDC) for the Somatic Cell Genome Editing Consortium (SCGE) will support integration of activities across the SCGE Program, using the extensive expertise of the team of investigators and program staff at the Medical College of Wisconsin. The SCGE TCDC will coordinate management and communication, establish platforms for communication and outreach, data and resource dissemination, and support intra-consortium collaborations. The goal of the SCGE TCDC is to facilitate and accelerate translational research projects from the pre-clinical stage through regulatory approval and clinical trials.

PI_NAMEs: DWINELL, MELINDA R (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Academia;Acceleration;Biological Assay;Clinic;Clinical Trials;Collaborations;Communication;Communities;Complex;Data;data access;Data Element;data format;data management;data platform;data quality;Development;disease-causing mutation;distributed data;Education and Outreach;Educational Activities;Educational workshop;Elements;ethical, legal, and social implication;experience;Foundations;Funding;genome editing;Goals;Government;Individual;Industry;Infrastructure;Leadership;medical schools;meetings;member;Organ;Outcome;outreach;Participant;Patients;Phase;Policies;pre-clinical;preclinical study;Procedures;Process;programs;Protocols documentation;Research Design;Research Personnel;Research Project Grants;Resources;Schedule;scientific organization;Series;somatic cell gene editing;success;System;Technology;Testing;Tissues;tool;Translating;translational goal;Translational Research;Translations;United States National Institutes of Health;user-friendly;Validation;virtual;Visualization;Wisconsin;Work;working group

PROJECT_TITLE: Translational Coordination and Dissemination Center for the SCGE Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-X(70)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease;Pediatric;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Lysosomal storage diseases are caused by genetic defects leading to anomalous accumulation of metabolites in lysosomes, the degradative and recycling compartment of the cell. These toxic products, when accumulated in large amounts, can be harmful to humans. The identification of novel mechanisms that regulate autophagy and compounds that improve cellular and organ function would lead to novel treatments for several human diseases including lysosomal storage disorders.

PI_NAMEs: CATZ, SERGIO DANIEL (contact);CHERQUI, STEPHANIE ;CUERVO, ANA MARIA;GAVATHIOTIS, EVRIPIDIS

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Affect;Animal Model;Apoptosis;Autophagocytosis;Biochemical;Brain;Cell Compartmentation;Cell Death;cell dedifferentiation;Cell model;Cell Physiology;Cells;Cellular biology;Cessation of life;Child;Chronic Kidney Failure;Clinical;Complement;Complementary therapies;Cysteamine;Cystine;Cystinosis;Data;Defect;detection of nutrient;Deterioration;Development;Disease;Down-Regulation;Event;Eye;Failure;Fanconi Syndrome;Functional disorder;functional improvement;Goals;Growth;Homeostasis;Human;human disease;Human Pathology;Impairment;improved;in vivo;Injury to Kidney;Kidney;LDL-Receptor Related Protein 2;Lead;Link;Liver;Lysosomal Storage Diseases;Lysosomes;Mediating;Membrane;Molecular;Molecular Chaperones;Mus;mutant;Mutation;nephropathic cystinosis;Nervous System Disorder;novel;novel therapeutics;Organ;Pathogenesis;Pathology;Pathway interactions;Patients;pediatrician;Pharmaceutical Chemistry;Predisposition;Proteins;receptor;reconstitution;Recycling;Regulation;Renal function;repaired;Research;Role;small molecule;superresolution microscopy;Testing;tissue injury;Tissues;trafficking;translational approach;young adult

PROJECT_TITLE: Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Project Narrative This partnership project between academic institutions (Johns Hopkins University and the University of Illinois at Urbana-Champaign) and vaccine development company (Advanced Bioscience Laboratories) and associated CMOs is to accelerate the development of a vaccine candidate against enterotoxigenic Escherichia coli (ETEC), the category B priority pathogens of NIH, serious threats of antibiotic resistance of CDC, and a top cause of children's diarrhea and travelers' diarrhea. Currently, there are no licensed vaccines for ETEC, but a unique multivalent subunit vaccine candidate (MecVax) developed based on a novel vaccinology platform is demonstrated to be broadly immunogenic and protect against ETEC clinical diarrhea and intestinal colonization in animal models. A broadly protective vaccine for ETEC can prevent >200 million diarrhea clinical cases and save nearly 100,000 lives annually.

PI_NAMEs: ZHANG, WEIPING  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Adherence;Adjuvant;aged;analytical method;Animal Model;Animals;anti-toxin;Antibiotic Resistance;Antibiotics;Antibodies;Antibody Response;Antigens;Bacteria;Bacterial Adhesins;Biological Assay;Biological Sciences;Biomass;Buffers;Category B pathogen;Cause of Death;cell bank;Cells;Cessation of life;Child;Clinical;Clinical Research;cognitive development;Collaborations;Cyclic GMP;Dehydration;Developing Countries;Development;Diarrhea;disability-adjusted life years;Dose;Economics;Engineering;enterotoxigenic Escherichia coli;Enterotoxins;Epitopes;Escherichia coli Adhesins;Escherichia coli Infections;Escherichia coli Vaccines;Excision;experience;Family suidae;Formulation;Goals;gut colonization;Heterogeneity;Homeostasis;Illinois;Immunity;immunogenic;Immunologic Tests;Immunologics;Industrialization;industry partner;innovation;Institution;International;juvenile animal;Knowledge;Laboratories;Leadership;Licensing;Life;Liquid substance;Malaria;manufacture;manufacturing test;Measles;Mediating;Modeling;novel;Nutritional;Oryctolagus cuniculus;Outcome;Plasmids;Play;pre-clinical;pre-Investigational New Drug meeting;preclinical study;Preparation;prevent;Process;product development;Production;protein expression;protein purification;Proteins;Protocols documentation;Public Health;Qualifying;receptor;Records;Reference Standards;Role;Running;Safety;Shigella Vaccines;Side;Small Intestines;Structure;Subunit Vaccines;synergism;Testing;Toxicology;Toxin;Traveler's diarrhea;UNICEF;United States National Institutes of Health;Universities;vaccine candidate;vaccine development;vaccine formulation;Vaccine Research;Vaccines;vaccinology;Virulence;Work;years of life lost to disability

PROJECT_TITLE: Development of MecVax, a Cross Protective Subunit Vaccine for ETEC


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse;Women's Health Research

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: This study develops, implements, and rigorously tests the effectiveness of an intervention administered in prenatal care to reduce women’s alcohol consumption during pregnancy, reduce alcohol-related birth outcomes, and reduce the proportion of infants observed with physical, cognitive, motor, and neurodevelopmental deficits at 6- and 12-month follow-up.

PI_NAMEs: DICLEMENTE, RALPH J (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: Address;Affect;alcohol abstinence;Alcohol consumption;alcohol consumption during pregnancy;alcohol risk;Alcohols;Biological Markers;Birth;Birth Rate;Characteristics;Cities;clinical care;clinically significant;Cognitive;Cognitive deficits;Collaborations;Computers;Counseling;Country;design;Development;Effectiveness of Interventions;effectiveness testing;efficacy evaluation;Eligibility Determination;Evidence based intervention;Face;Family health status;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;follow-up;Glucuronides;Growth;High Prevalence;Human;Hybrids;Infant;Informed Consent;Intervention;intervention effect;Knowledge;Laboratories;Maternity Hospitals;Medical Records;Mothers;Motivation;Motor;motor deficit;Neurodevelopmental Deficit;Outcome;Participant;Physical assessment;Pilot Projects;point of care;Pregnancy;Pregnant Women;Premature Birth;prenatal;Prenatal care;preventive intervention;Randomized;Randomized, Controlled Trials;Recommendation;recruit;reduced alcohol use;Reproduction;Research;Research Personnel;Risk;Russia;Schedule;Second Pregnancy Trimester;standard of care;Testing;theories;Third Pregnancy Trimester;Treatment Efficacy;Urine;Woman

PROJECT_TITLE: Designing a Hybrid Intervention Strategy to Reduce Alcohol Exposed Pregnancies.


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Genetics;Mental Health;Neurosciences;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Alcohol misuse is often associated with pathological aggression, a recurrent pattern of disruptive and violent behavior, with a staggering socioeconomic impact. The animal studies proposed in this application will identify the mechanisms underlying the common causes of these two conditions, as well as their reciprocal interac- tions. Our results may lead to the identification of new targets for the treatment and prevention of alcohol-asso- ciated violence.

PI_NAMEs: BORTOLATO, MARCO  (contact);MANGIERI, REGINA A.

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Acute;Adolescence;Adverse effects;Aggressive behavior;alcohol abuse therapy;alcohol and other drug;alcohol comorbidity;Alcohol consumption;alcohol effect;alcohol misuse;alcohol prevention;alcohol reinforcement;alcohol reward;alcohol risk;Alcohols;Alleles;Anger;Animal Model;Animals;antagonist;Behavioral;Biological;Child Abuse and Neglect;Clinical;comorbidity;Complex;conditioned place preference;Corticotropin-Releasing Hormone;CRF receptor type 1;Data;Development;Dopamine;Dose;drug of abuse;early life exposure;early life stress;Economic Burden;economic impact;Electrophysiology (science);Enzymes;Female;gene environment interaction;Genes;Genetic Carriers;Genotype;Glutamate Receptor;high risk;Human;Impairment;Individual;Life;Link;male;Modeling;Monoamine Oxidase A;Mus;mutant;Mutation;N-Methylaspartate;neurobiological mechanism;Neurons;novel therapeutics;Nucleus Accumbens;Pathologic;Pattern;postnatal;preference;Prefrontal Cortex;Prevention;Process;pup;Receptor Activation;receptor function;Recording of previous events;Recurrence;Regimen;reinforced behavior;Research;Serotonin;Shapes;Signal Transduction;Slice;social;socioeconomics;Testing;Time;transmission process;Variant;Violence

PROJECT_TITLE: Disentangling the biological links between violence and alcohol use

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Behavioral and Social Science;Social Determinants of Health

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed Washington State University ESTEEMED program (MIRA) will equip high achieving freshman and sophomores from underrepresented groups with the skills needed to complete their undergraduate degrees, matriculate into a graduate program, and pursue a career in biomedical research. Through the WSU MIRA program, a diverse and well-trained pool of scientists and engineers will contribute to creative and innovative health solutions allowing the United States to remain a world leader in biomedical sciences. Moreover, by increasing diversity in the biomedical sciences workforce MIRA will enable the United States to eliminate health disparities across the nation by providing an empathetic workforce that reflects all socioeconomic backgrounds.

PI_NAMEs: GIZERIAN, SAMANTHA ;KOSTYUKOVA, ALLA S.;LANIER, MARY SANCHEZ (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Academic advising;academic preparation;Academic support;Acculturation;Achievement;Adopted;Area;Award;Bachelor's Degree;Biomedical Research;biomedical scientist;career;career networking;college;Communication;Communities;community building;Creativeness;Critical Thinking;Degree program;Development;Development Plans;disadvantaged background;Doctor's Degree;Education;Educational Curriculum;Educational workshop;Empathy;Engineering;Environment;Event;Evidence based practice;experience;Family;Feeling;Foundations;Frustration;Goals;graduate school;Health;health disparity;high school;improved;Individual;innovation;Intervention;Knowledge;Mathematics;matriculation;Measurable;Measures;meetings;Mentors;Monitor;Motivation;novel;oral communication;Outcome;Pathway interactions;peer;peer coaching;Personal Satisfaction;Population;Preparation;Productivity;programs;Research;Research Personnel;Research Project Grants;Resources;role model;Scholars Program;Science;Scientist;skills;social;social integration;Social support;socioeconomics;STEM field;student participation;Students;success;supportive environment;symposium;tool;Training;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;underserved community;Underserved Population;United States;Universities;Washington;Writing

PROJECT_TITLE: Motivating Innovation and Research Achievement (MIRA)


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Tracheal intubation (TI) in the neonatal intensive care unit (NICU) is frequently complicated by adverse safety outcomes such as adverse tracheal intubation associated events, multiple TI attempts, and oxygen desaturation. We have developed, refined, and tested a Personalized INtubation Safety (PINS) Bundle that targets 5 evidence-based domains for a prospective and individualized approach to TI planning and management. We propose a pragmatic stepped wedge cluster randomized trial of NICU patients who are intubated across 8 participating hospitals to determine if the PINS Bundle, compared to no PINS Bundle, reduces the incidence of adverse tracheal intubation associated events.

PI_NAMEs: FOGLIA, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Accounting;Address;Adverse event;Caring;Child;Childhood;Classification;Clinical;Cluster randomized trial;Competence;Critical Illness;Educational Status;Educational workshop;Effectiveness;effectiveness evaluation;Emergency Situation;Ensure;Equipment;Event;evidence base;experience;Extubation failure;Funding;Goals;high risk;Hospitals;improved;Incidence;Individual;Infant;Infrastructure;Institution;Intention;Intervention;Intratracheal Intubation;intraventricular hemorrhage;Intubation;Laryngoscopes;Laryngoscopy;Learning;Life;Mechanical ventilation;Methodology;Modification;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;National Institute of Child Health and Human Development;Neonatal;neonatal airway;Neonatal Intensive Care;Neonatal Intensive Care Units;neonatal patient;neonate;Outcome;Oxygen;Paralysed;Patient risk;patient safety;Patient-Focused Outcomes;Patients;personalized approach;post intervention;practice factors;Premature Infant;Premedication;primary outcome;Procedures;prospective;prototype;Provider;Randomized;Recommendation;Registries;Research;Resuscitation;Risk;Risk Assessment;Safety;safety outcomes;secondary outcome;Site;skills;success;Testing;Time;tool;treatment effect;Update;uptake;ventilation

PROJECT_TITLE: Optimizing Tracheal Intubation Outcomes and Neonatal Safety (OPTION SAFE)

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE An estimated 1 in 5 women and 1 in 15 men experience sexual violence. We seek to reduce this violence through a new Motivational Interviewing intervention to decrease heavy drinking and encourage young adults to intervene with their peers to prevent sexual assault—an approach known as bystander intervention.

PI_NAMEs: DILILLO, DAVID  (contact);GERVAIS, SARAH JEAN

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Adopted;Alcohol consumption;alcohol intervention;Alcoholic beverage heavy drinker;Alcohols;attentional control;Attitude;Behavior;Behavior Therapy;college;Communities;comparative efficacy;design;diaries;Diffuse;drinking;Education;Educational Intervention;efficacy testing;Electronics;Evaluation;Evaluation Studies;Event;evidence base;experience;Goals;Heavy Drinking;high risk;Hour;Impairment;Individual;Intervention;intervention program;Intoxication;Knowledge;Measurement;Measures;men;Methods;Motivation;motivational enhancement therapy;multimodality;novel;Outcome;Participant;Patient Self-Report;peer;Persons;Positioning Attribute;post intervention;Prevalence;prevent;Prevention;preventive intervention;Program Evaluation;psychoeducation;Public Health;Randomized, Controlled Trials;Readiness;recruit;reduced alcohol use;Reporting;response;Risk;Risk Factors;Sampling;sexual assault;sexual violence;Sexual violence prevention;Testing;Time;Training;Training Programs;Violence;virtual reality;Woman;young adult

PROJECT_TITLE: RCT of a combined MI intervention to address bystander behaviors in the context of alcohol use

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE The goal of this proposal is to advance the pre-clinical development of a broad spectrum Shigella vaccine consisting of Shigella flexneri (S. flex.) 2a, and S. sonnei O-polysaccharide (OPS) conjugated to Shigella IpaB (a highly immunogenic and protective Type III secretion system protein) using innovative technology: cell-free expression of IpaB and precise (site-specific) OPS-IpaB conjugation. S. flex 2a OPS-IpaB elicited robust immune responses in mice and afforded high levels of protection against S. flex 2a and S. sonnei lethal infection; a bivalent S. flex 2a and S. sonnei OPS-IpaB conjugate vaccine is expected to have broad efficacy and cover the most relevant disease-causing serotypes. UMB and Vaxcyte have partnered to refine and scale up vaccine production, assess vaccine efficacy and protective immunity in animal models, and establish cGMP manufacturing procedures in preparation for toxicology studies and clinical evaluation.

PI_NAMEs: PASETTI, MARCELA F (contact)

PROJECT_TERMS: 3 year old;5 year old;Adjuvant;Advanced Development;Affect;Age;Agonist;aluminum sulfate;Animal Model;Antibiotic Resistance;Antibodies;Antigens;antimicrobial;Antimicrobial Resistance;Biological Assay;Carrier Proteins;Cavia;Cells;Child;Childhood;Clinical;Clinical Trials;cognitive disability;Combined Vaccines;Conjugate Vaccines;cost;cross reacting material 197;Cyclic GMP;Day center care;Developed Countries;Development;Developmental Disabilities;Diarrhea;Diphtheria Toxoid;disability;Disease;Disease Outbreaks;Dysentery;Evaluation;Exotoxins;experimental study;Fc Receptor;Formulation;Goals;Human;IgG1;Immune;Immune response;Immune Sera;Immunity;Immunize;immunogenic;immunogenicity;Immunoglobulin G;Immunologics;Immunology;immunoreactivity;Immunosuppression;Impaired health;In Vitro;in vivo;Individual;Industrialization;Infection;infection risk;innovative technologies;Institution;Intramuscular;Life Expectancy;Link;Lung;manufacture;manufacturing scale-up;Maryland;Medical;Modeling;Multi-Drug Resistance;Mus;mutant;novel;O Antigens;Oligosaccharides;Organism;Oryctolagus cuniculus;Pathogenicity;Pattern;Phagocytes;Polysaccharides;Poverty Areas;preclinical development;Preparation;prevent;Procedures;Process;process optimization;Proctocolitis;protective efficacy;protein expression;Protein Secretion;Proteins;Pseudomonas aeruginosa;Pulmonary Challenge;receptor binding;Reporting;Research;research clinical testing;resistant strain;response;Safety;Sanitation;scale up;Serotyping;Serum;Severities;Shigella;Shigella flexneri;Shigella Infections;Shigella sonnei;Shigella Vaccines;Site;System;Technology;Testing;Tetanus Toxoid;Time;TLR4 gene;Toddler;Toxicology;Type III Secretion System Pathway;Universities;unvaccinated;vaccine candidate;vaccine efficacy;Vaccine Production;vaccine strategy;Vaccines;Water

PROJECT_TITLE: O-polysaccharide (OPS)-IpaB Conjugate Vaccine to Prevent Shigellosis


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Vanderbilt FIRST will build on prior success and implement novel, equitable and inclusive strategies to recruit, retain, mentor and promote early-career scientific faculty from racial groups historically excluded from science. Ultimately, efforts will lead to sustainable transformation and an institutional culture of inclusive excellence.

PI_NAMEs: GAMA, VIVIAN ;RAVER, C CYBELE;WILKINS, CONSUELO HOPKINS (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Academia;American Indians;anti-racism;Arts;Basic Science;Black race;career;career development;cohesion;Communities;Compensation;Data;Decision Making;Development;Disparity;diversity and inclusion;Doctor of Philosophy;Early identification;Education;effectiveness evaluation;Engineering;Environment;Equity;equity, diversity, and inclusion;ethnic diversity;Ethnic Population;Evaluation;evidence base;Exclusion;experience;Faculty;Fostering;Funding;Goals;graduate student;health equity;Health Sciences;higher education;Hispanic;improved;Inequity;innovation;Institution;Institutional Policy;Institutional Racism;Justice;Latinx;Lead;Leadership;lectures;lens;marginalization;Measures;Medicine;member;Mentors;Minority Groups;novel;Outcome;Pacific Islander;Policies;Positioning Attribute;Postdoctoral Fellow;Process;programs;Public Health;racial diversity;racial minority population;racial population;recruit;research faculty;Research Personnel;Resource Development;Resources;Role;Science;Scientist;Senior Scientist;Series;social;Strategic vision;success;Teacher Professional Development;tenure track;Trauma;United States National Institutes of Health;Universities;Woman;women faculty;Work

PROJECT_TITLE: Vanderbilt FIRST - Elevating Excellence and Transforming Institutional Culture


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: WILKINS, CONSUELO HOPKINS (contact)

PROJECT_TERMS: Academia;Accountability;Address;American Indians;Appointment;Area;Award;Basic Science;Black race;career;Climate;cohort;Communication;Data;Doctor of Philosophy;Ensure;Equity;equity, diversity, and inclusion;Ethnic Population;Exclusion;experience;Faculty;Fostering;Goals;health equity;Home;Human Resources;Individual;Infrastructure;innovation;Institution;Institutional Policy;Institutional Practice;Knowledge;Latinx;Leadership;Medicine;organizational climate;Organizational Efficiency;organizational structure;Pacific Islander;Policies;Principal Investigator;Productivity;programs;racial diversity;racial minority population;racial population;recruit;Resource Development;Resources;Secure;Teacher Professional Development;tenure track;tool;United States National Institutes of Health

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-W]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE This resubmitted training program will prepare PhD students and postdoctoral researchers to conduct research on prevention and treatment of chronic diseases such as cancer, stroke, or Alzheimer’s Disease and Related Disorders among older adults. Our program emphasizes giving trainees the skills to move from evidence to public health impact via implementation and translational efforts. This proposal would renew support for a second cycle building on the successes of the first five years of the program.

PI_NAMEs: CAWTHON, PEGGY MANNEN;TORRES, JACQUELINE MARIE (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TITLE: Translational Epidemiology - Training for Research on Aging and Chronic disease


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: HASTY, ALYSSA H (contact)

PROJECT_TERMS: Address;Award;career;career development;Career Mobility;cohort;collaborative environment;Communities;community building;Department chair;Development;early-career faculty;Elements;Ensure;Environment;equity, diversity, and inclusion;Ethnic Population;expectation;Face;Faculty;faculty mentor;faculty support;Feeling;Foundations;Freedom;Funding;gender equity;Goals;graduate school;Grant;health equity;Individual;Inequity;innovation;Institution;interest;Leadership;leadership development;lectures;Letters;Medicine;meetings;member;Mentors;mid-career faculty;next generation;operation;peer;peer networks;Positioning Attribute;Productivity;Program Development;programs;Race;racial diversity;Racial Equity;racial minority;racial minority population;recruit;Research;Resources;Role;Scientist;senior faculty;Senior Scientist;Series;Services;skill acquisition;skills;social;Social support;Socioeconomic Status;Stereotyping;success;Talents;Teacher Professional Development;tenure track;Training;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Faculty Development Core


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE About half of women presenting for breast cancer screening in the U.S. have dense breast tissue, which makes cancer detection more difficult on mammography, even when performed as a tomosynthesis exam (3D mammography), and puts these women at a higher risk of delayed detection and breast cancer death. Yet, there is no consensus on which supplemental screening technique should be offered to improve cancer detection among women with dense breasts. In this work, we will perform the first multi-institutional trial (called Density MATTERS) to evaluate whether adding the functional imaging technique of molecular breast imaging (MBI) to tomosynthesis or performing MBI instead of tomosynthesis can improve cancer detection and reduce late-stage cancers, thereby providing a cost-effective, well-tolerated, and safe screening solution to reduce the burden of breast cancer in women with dense breasts.

PI_NAMEs: HRUSKA, CARRIE B (contact);RHODES, DEBORAH

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: 3-Dimensional;Address;Adoption;Advanced Malignant Neoplasm;Algorithms;attenuation;Biopsy;Breast;Breast Cancer Detection;Breast Cancer Early Detection;breast density;breast imaging;cancer clinical trial;Cancer Detection;cancer invasiveness;Cessation of life;Characteristics;Clinical;clinical practice;Clinical Trials;cohort;comparative cost effectiveness;Complex;Consensus;cost;cost comparison;cost effective;Country;Coupled;Data;Dedications;denoising;density;Detection;detector;Diagnostic;diagnostic accuracy;Digital Breast Tomosynthesis;Dose;empowerment;Failure;Functional Imaging;Gadolinium;Gamma Cameras;Head;high risk;Image;Image Guided Biopsy;image processing;imaging detection;Imaging Techniques;Imaging technology;improved;Institution;Laws;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;Mammographic screening;Mammography;Masks;Mission;Modality;Molecular;mortality;Multi-Institutional Clinical Trial;Outcome;Participant;patient population;Patients;Performance;Phase II Clinical Trials;Population;Positioning Attribute;practice setting;prevent;prospective;Radiation;Radiation Dose Unit;Radiation exposure;radiotracer;Reader;research clinical testing;Resolution;Risk;Roentgen Rays;Safety;screening;Screening for cancer;screening guidelines;Screening procedure;screening program;Statutes and Laws;supplemental screening;Technetium 99m;Techniques;Technology;Testing;Tissues;tomosynthesis;tool;Translating;tumor;uptake;Validation;Woman;Women's mortality;Work

PROJECT_TITLE: Density MATTERS Clinical Trial

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative Deficits in neuronal circuit assembly in the visual system are implicated in a variety of disorders; thus, establishing correct wiring patterns of neuronal circuits during development is essential for proper brain functioning. The proposed research has high levels of public health relevance because we will combine circuit level insights on long-range neuronal connectivity development with gene expressions to illuminate a new way to determine novel therapeutic targets for neurodevelopmental disorders such as schizophrenia and autism. This work aligns with NIH’s mission to transform the understanding and treatment of visual disorders and mental illnesses.

PI_NAMEs: KIM, EUISEOK J (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Adhesions;analog;Anatomy;Anterolateral;Area;area striata;autism spectrum disorder;Axon;Birth;Brain;Cell Adhesion Molecules;cell type;Cells;Data;Date of birth;Defect;Development;Developmental Process;Disease;Dyslexia;extrastriate visual cortex;Family;Feedback;Foundations;Gene Expression;Genetic;genetic manipulation;Goals;Human;In Situ Hybridization;Individual;innovation;insight;Knowledge;Label;Link;Medial;Mediating;Mental disorders;Messenger RNA;Methods;Mission;Modeling;Molecular;Motor;Mus;neural;neural circuit;Neurodevelopmental Disorder;neuromechanism;neuronal circuitry;neuronal patterning;Neurons;Neurosciences;new therapeutic target;novel therapeutics;Outcome;Output;Pattern;Phenotype;presynaptic neurons;prevent;Process;Production;programs;Projections and Predictions;Property;public health relevance;rabies viral tracing;Regulation;Research;Role;Schizophrenia;Sensory;single molecule;Solid;Source;Specific qualifier value;Specificity;Synapses;synaptic pruning;Testing;Therapeutic Intervention;Thymidine;United States National Institutes of Health;V1 neuron;virus genetics;Vision Disorders;Visual;Visual Cortex;Visual System;Work

PROJECT_TITLE: Developmental Mechanisms of Fine-scale Cortico-cortical Circuit Formation

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]