ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: SAINT LOUIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Public Health Relevance Statement Sexual minority adolescents (SMA; ages 13-17) are more likely to experience intimate partner violence (IPV) than their heterosexual peers. However, research on the relationship between IPV and individuals who identify as a sexual minority has largely focused on adults. The overarching goal of this study is to explore the prospective relationship among IPV experiences, risk and resilience factors, and other behavioral health outcomes in a national cohort of SMA.

PI_NAMEs: GOLDBACH, JEREMY THOMAS (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: Academy;Address;Adolescence;Adult;Advisory Committees;Age;Anxiety;Area;Attention;Attenuated;Behavior;Behavior Control;behavioral health;Characteristics;Cities;cohort;Cross-Sectional Studies;demographics;Development;Emotional;emotional abuse;epidemiology study;Ethnic Origin;Etiology;experience;Failure;Female;Forcible intercourse;Frequencies;Friends;Future;Gays;Gender;Gender Identity;gender minority group;Geography;Goals;Health;help-seeking behavior;Heterosexuals;High Prevalence;Homelessness;Hybrids;Individual;Intervention;intimate partner violence;lens;Lesbian;Lesbian Gay Bisexual Transgender;Literature;Lived experience;Longitudinal Studies;male;Measurement;Measures;Medicine;Mental Depression;Mental Health;Methods;minority stress;Outcome;Participant;Pattern;peer;perpetrators;physical abuse;poor health outcome;Population;prospective;protective factors;psychologic;Psychopathology;Public Health;Race;recruit;Reporting;Research;resilience;resilience factor;Respondent;Risk;Risk Factors;role model;Sampling;Science;Services;Severities;sexual assault;sexual minority;sexual minority group;sexual minority youth;Sexuality;social media;Social support;substance use;Time;United States National Institutes of Health;Urbanicity;verbal;Victimization;Violence;violence perpetration;violence victimization;Work

PROJECT_TITLE: Trajectories of intimate partner violence among sexual minority youth

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Precision Medicine;Primary Health Care;Telehealth

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE Digital mental health interventions are a cost-effective and efficient approach to expanding the accessibility and impact of psychological treatments; however, little guidance exists for selecting the most effective program for a given individual. In the proposed study, we will use machine learning to create decision rules for selecting the digital program that is most likely to be the optimal intervention for each user. These treatment recommendations can be implemented in the context of large healthcare delivery systems to improve the delivery of digital mental health interventions at scale.

PI_NAMEs: FARCHIONE, TODD J. (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Address;algorithm development;algorithmic methodologies;Algorithms;Anxiety;Area;Behavioral;Characteristics;Clinical;clinical decision-making;clinical trial participant;Cognitive;Cognitive Therapy;cost;cost effective;design;Development;Diagnostic;digital;digital delivery;digital healthcare;digital intervention;digital mental health;Disease remission;Effectiveness;Emotional disorder;evidence base;Evidence based intervention;Health;health care delivery;Healthcare Systems;improved;Individual;Individual Differences;ineffective therapies;Internet;Intervention;Judgment;Lead;Machine Learning;machine learning algorithm;Mental Depression;Mental disorders;Mental Health Services;National Institute of Mental Health;Neurotic Disorders;optimal treatments;Outcome;Patients;Pattern;Personal Satisfaction;personalized medicine;Precision therapeutics;Primary Care Physician;programs;Protocols documentation;Psychological Impact;Randomized;randomized, clinical trials;Recommendation;relative effectiveness;Research;resilience;response;Sample Size;supervised learning;Symptoms;System;Testing;theories;Therapeutic;Thinking;Time;treatment response;Work

PROJECT_TITLE: Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Genetic evidence implicates dysregulation of lipid metabolism and immune function in the neurodegenerative pathogenesis of Alzheimer's disease (AD), what is less clear is how these different factors combine to affect brain aging and AD risk. In this project we will combine highly validated state-of-the-art lipidomic profiling with genetics and brain imaging data to identify both peripheral and central lipid metabolic pathways contributing to AD risk and resilience allowing for identification of new biomarkers to identify those at high risk of developing AD as well as new therapeutic targets for the prevention and treatment of AD.

PI_NAMEs: ARNOLD, MATTHIAS ;KADDURAH-DAOUK, RIMA F (contact);MEIKLE, PETER JOHN

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Acceleration;Affect;Age;age effect;age related changes;Aging;aging brain;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;amyloid pathology;Apolipoprotein E;Area;Atlases;biobank;Biochemical Pathway;Biochemistry;Biological Markers;biomarker identification;blood lipid;Brain;brain health;Brain imaging;Catalogs;CD36 gene;Cells;Cognition;cognitive change;cohort;Data;data integration;Data Set;data sharing;Dementia;Diet;Disease;Disease Progression;Disease susceptibility;drug development;drug discovery;Drug Targeting;Early identification;Early Intervention;Ethers;Evolution;Failure;Genes;Genetic;genetic risk factor;genome wide association study;Genotype;Glucose;Heterogeneity;high risk;Human;Immune;immune function;Immune system;immunoregulation;Impaired cognition;improved;Informatics;insight;Intervention;Investments;Late Onset Alzheimer Disease;Least-Squares Analysis;Life Style;lifestyle intervention;Link;lipid metabolism;lipid transport;lipidome;lipidomics;Lipids;loss of function;Machine Learning;Maps;Mediating;Mediation;Medicine;Mendelian randomization;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Methods;Modeling;Molecular;Monitor;multiple omics;Nerve Degeneration;new therapeutic target;novel;novel therapeutic intervention;Outcome;Pathogenesis;Pathway interactions;Peripheral;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Plasma;Population Study;predictive signature;Predisposition;preservation;prevent;Prevention;Process;Regulation;Reporting;Reproducibility;Research;resilience;Resources;Risk;Risk Factors;risk variant;Role;Sampling;Sex Differences;Systemic disease;Time;tool;Treatment Efficacy;Variant;Work

PROJECT_TITLE: Metabolic age to define influences of the lipidome on brain aging in Alzheimer's disease


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: RALEIGH

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE In this proposal, new methods to access libraries of peptide conformers are described. These methods will ultimately enable structure-activity relationships (SAR) studies of bioactive peptides, while increasing protease stability and rigidifying peptide secondary structures. Taken together, this should expedite the discovery of peptidomimetics with improved therapeutic potential.

PI_NAMEs: PROULX, CAROLINE  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TITLE: New Strategies for Peptide Mimicry


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative The Preventing infant infections by Implementation Science in Malawi (PRI3SM) project will conduct 3 related studies addressing the main reasons for pediatric HIV infections in Malawi, supported by administrative, implementation science and data science and analytical cores. Project 1 and Project 2 focus on preventing new infections in Mothers during pregnancy and breastfeeding and Project 3 focuses on promptly testing infants born to mothers with potential higher risk to transmit based on missing key services. PRI3SM has potential to reduce pediatric infection in Malawi and may provide a successful model for other countries to follow.

PI_NAMEs: HOSSEINIPOUR, MINA CHRISTINE (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Address;Adoption;AIDS prevention;antenatal;antiretroviral therapy;Behavior;Breast Feeding;Caring;case finding;Child;Child Care;Childhood;Clinic;Clinic Visits;Clinical Research;Clinical Sciences;cohort;Communities;community based service;Community Outreach;cost;Country;Data Analytics;Data Science;Development;Diagnosis;Drops;Early Diagnosis;Early treatment;Effectiveness;effectiveness evaluation;effectiveness measure;effectiveness outcome;Ensure;Epidemiology;experience;Foundations;Frequencies;future implementation;Goals;Health;high risk;High Risk Woman;HIV;HIV Infections;Human immunodeficiency virus test;Immunization;implementation measures;implementation outcomes;implementation science;implementation strategy;Infant;infant infection;infant outcome;Infection;Injectable;innovation;Intervention;Lactation;Malawi;Modeling;Mother-to-child HIV transmission;Mothers;National Institute of Child Health and Human Development;novel;Oral;pediatric human immunodeficiency virus;pediatric human immunodeficiency virus infection;Personal Satisfaction;point of care;Policies;Population;Positioning Attribute;Postpartum Period;pre-exposure prophylaxis;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;prevent;Prevention;Program Evaluation;programs;Prophylactic treatment;Protocols documentation;Regimen;Registries;Request for Applications;Research;Research Personnel;Research Project Grants;Risk;Safety;Science;seroconversion;Service delivery model;Services;Structure;Testing;tool;transmission process;treatment program;United States National Institutes of Health;uptake;Vertical Disease Transmission;Viral;Viral Load result;Woman

PROJECT_TITLE: Preventing Infant Infections with Implementation Science in Malawi


NIH_SPENDING_CATS: Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Pediatric;Prevention

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS prevention;biobank;Caring;Childhood;Clinical;Clinical Trials Network;cohort;Collaborations;Collection;Communication;community partners;Data;Data Analytics;Data Science;Decision Making;Dedications;Electronic Mail;Ensure;Evaluation;Foundations;Funding;Goals;Grant;Health;HIV;Human Subject Research;implementation research;implementation science;implementation strategy;Individual;Infant;infant infection;Information Systems;Infrastructure;instrument;International Maternal Pediatric Adolescent AIDS Clinical Trials;Malawi;Manuscripts;meetings;Mission;Monitor;National Institute of Child Health and Human Development;operation;Parents;Perinatal;Play;Policies;pre-exposure prophylaxis;pregnant;Preparation;prevent;Procedures;Program Evaluation;programs;Progress Reports;Protocols documentation;Regimen;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;research study;Role;Safety;Schedule;Science;Site;Specimen;symposium;Training;Update;Woman;Work;working group

PROJECT_TITLE: Administrative Core [Parent Title: PREVENTING INFANT INFECTIONS WITH IMPLEMENTATION SCIENCE IN MALAWI]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: ATHENS

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE Trypanosoma cruzi is an obligate intracellular parasite of the kinetoplastid family that infects upwards of 10 million people in the Americas with approximately 30% developing life-threatening clinical disease. As part of its basic nutrient acquisition strategy, T. cruzi directly ingests extracellular material via an enigmatic endocytic structure known as the cytostome/cytopharynx complex (SPC) and this study seeks to characterize the molecular machinery responsible for constructing, powering and regulating this endocytic organelle. Our work seeks to address a longstanding question regarding the primary role of the SPC in the parasite life cycle as it serves as one of the major points of contact in the host-pathogen interface during infection.

PI_NAMEs: ETHERIDGE, RONALD DREW (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Adult;Americas;Arthropod Vectors;Basic Science;Biological;Biology;burden of illness;Cell membrane;Cells;Chagas Disease;Clinical;combat;comparative;Complex;CRISPR/Cas technology;Cytosol;Data;Defect;Digestion;Disease;electron tomography;Elements;Endocytosis;Environment;Etiology;extracellular;Family;Feces;feeding;Gastrointestinal tract structure;Gene Deletion;gene editing technology;Genetic;Goals;Growth;Hindgut;Human;Individual;Infection;Ingestion;Insect Vectors;Insecta;insight;Invaded;Knock-out;knockout gene;Leishmania;Life;Life Cycle Stages;lipidomics;Lipids;Measurable;Mediating;Molecular;Molecular Analysis;Molecular Motors;Molecular Target;Motor;mutant;Myosin ATPase;neglect;novel;Nutrient;obligate intracellular parasite;Oral;Organelles;Organism;Orphan;Parasites;Parasitic infection;pathogen;Pathway interactions;Persons;Play;Populations at Risk;Process;protein complex;Proteins;Proteomics;Publishing;Rectum;Resources;Role;Structure;subcellular targeting;Surface;Techniques;Time;tool;transmission process;Trypanosoma brucei brucei;Trypanosoma cruzi;Tubular formation;uptake;Validation;vector;vector transmission;Vesicle;virtual;Work

PROJECT_TITLE: Elucidating the Role of Endocytosis Via the Cytostome in the Life Cycle of Trypanosoma cruzi

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

PI_NAMEs: PENCE, BRIAN W (contact)

PROJECT_TERMS: Address;Applied Research;Breast Feeding;Clinical Sciences;Data Collection;Development;doctoral student;Ensure;Evaluation;evidence base;Evidence based intervention;experience;Fellowship;Funding;Goals;Guidelines;HIV;implementation evaluation;implementation facilitation;implementation intervention;implementation measures;implementation outcomes;implementation research;implementation science;implementation strategy;improved;infant infection;innovation;Institution;International;Internships;Intervention;Knowledge;Learning;Malawi;Manuscripts;Measurement;meetings;member;Mental Health;Mentors;Monitor;North Carolina;organizational readiness;Outcome;Parents;postnatal;prevent;Prevention;programs;protocol development;real world application;Research;Research Design;Research Personnel;Research Project Grants;Resources;scale up;Science;Scientist;Series;skills;synergism;Testing;tool;Training;Training Programs;Translating;Translational Research;Translations;United States National Institutes of Health;Validation;Vertical Disease Transmission;Wit;Woman

PROJECT_TITLE: Implementation Science Core [Parent Title: PREVENTING INFANT INFECTIONS WITH IMPLEMENTATION SCIENCE IN MALAWI]


NIH_SPENDING_CATS: Bioengineering;Data Science;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

PI_NAMEs: CHAGOMERANA, MAGANIZO  (contact)

PROJECT_TERMS: Acceleration;Active Learning;Adherence;AIDS clinical trial group;algorithm development;analytical method;Aptitude;Biometry;Breast Feeding;built environment;Caring;Childhood;clinical care;Clinical Investigator;Clinical Trials;Clinical Trials Network;cohort;Collaborations;Collection;Common Data Element;Competence;Conceptions;Data;Data Analyses;Data Analytics;Data Collection;data management;Data Management Resources;data quality;Data Science;Database Management Systems;Databases;Dedications;design;Development;Discipline;diverse data;Electronics;Ensure;Epidemiology;Evaluation;Faculty;Family;Funding;Goals;Health;HIV prevention trials network;implementation research;implementation science;improved;Incidence;Infant;infant infection;Information Systems;Intervention;intervention effect;Link;Malawi;maternal outcome;mathematical model;Measurement;meetings;Mentors;Methods;Modeling;Monitor;Mothers;novel strategies;Observational Study;Outcome;Paper;Parents;Patient Outcomes Assessments;pediatric human immunodeficiency virus infection;perinatal HIV;pre-exposure prophylaxis;prediction algorithm;pregnant;Prevalence;prevent;Program Research Project Grants;programs;quality assurance;Quality Control;Registries;Regulation;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resource Sharing;Risk Factors;Sample Size;Scientist;Security;skills;Source;Statistical Data Interpretation;statistics;synergism;System;Systems Development;tool;Training;transmission process;United States National Institutes of Health;uptake;Vertical Disease Transmission;Viral Load result;Woman

PROJECT_TITLE: Data Science and Analytical Core [Parent Title: PREVENTING INFANT INFECTIONS WITH IMPLEMENTATION SCIENCE IN MALAWI]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: NEW HAVEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative  Our goal is to elucidate how biophysical inputs from tissue microenvironments program molecular and cellular interactions and drive phenotypic state transitions.

PI_NAMEs: MAK, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TITLE: Systems Biophysics of Multiscale State Transitions in Cells and Tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE This research proposal seeks to augment immune therapy responses in high-risk neuroblastoma, an aggressive pediatric solid tumor, by validating tumor cell lineage state as an indicator of immunogenicity and by developing strategies to relieve the epigenetic repression of tumor cell-intrinsic immune response genes. These studies have the potential to enable the stratification of patients who are most likely to benefit from immune therapy and to stimulate the design of clinical trials involving combinations of epigenetic and immune-based therapies to target the specific immune evasion mechanisms utilized by neuroblastoma cells.

PI_NAMEs: GEORGE, RANI E. (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Adoptive Immunotherapy;Adoptive Transfer;Adrenergic Agents;Affect;anti-tumor immune response;Antibodies;Antigens;Biological Markers;cancer cell;CD94 Antigen;Cell Lineage;Cell Therapy;Cells;Characteristics;Childhood Extracranial Solid Tumor;Childhood Solid Neoplasm;Clinical Trials Design;Cluster Analysis;Complex;Cytotoxic T-Lymphocytes;Data Set;design;Development;Epigenetic Process;Exhibits;Gene Activation;Gene Expression Profile;Genes;genetic signature;Goals;Heterogeneity;high risk;humanized mouse;Immune;immune activation;immune cell infiltrate;immune checkpoint blockade;Immune Evasion;Immune response;Immune Response Genes;Immune system;immunogenic;immunogenicity;Immunologics;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;Infiltration;Inflammatory Response;innate immune sensing;innovation;Licensing;Ligands;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Mesenchymal;Mesenchymal Cell Neoplasm;Modeling;Molecular;Monoclonal Antibodies;Mutation;MYCN gene;Natural Killer Cell Immunotherapy;Natural Killer Cells;neoplastic cell;Neural Crest;Neuroblastoma;neuroblastoma cell;Neurons;NK Cell Activation;NK cell therapy;Oncogenes;Patient Selection;patient stratification;Patients;Phenotype;Population;pre-clinical;Primary Neoplasm;Productivity;programs;Property;receptor;Regimen;Repression;Research Proposals;Resistance;response;Role;Sampling;Shapes;single-cell RNA sequencing;success;T cell infiltration;T cell therapy;T-Lymphocyte;Testing;transcription factor;Translating;treatment response;treatment strategy;tumor;tumor growth;tumor microenvironment;Tumor Suppression;Undifferentiated;Up-Regulation

PROJECT_TITLE: Cell lineage as an indicator of immune response in neuroblastoma

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Drug Abuse (NIDA only);Stimulant Use and Misuse;Substance Misuse

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Cocaine (COC) use disorder (CUD) remains a significant concern for which there is no FDA-approved medication treatment. Preclinical studies provide ample support for the potential clinical utility of stimulating the glucagon- like peptide 1 (GLP-1) receptor (GLP-1R) to treat CUD. The design of the current human clinical pharmacology study will accurately predict the potential clinical efficacy of a GLP-1R agonist for reducing COC use.

PI_NAMEs: VERRICO, CHRISTOPHER D (contact)

PROGRAM_OFFICER_NAME: FOSTER, KATRINA L

PROJECT_TERMS: Abstinence;abuse liability;Acceleration;Acute;Adverse effects;Adverse event;Agonist;Attenuated;Behavior;Behavior Therapy;Blood Pressure;Chronic;Clinical;clinical efficacy;Clinical Pharmacology;clinical practice;clinical predictors;Clinical Research;Cocaine;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;Cocaine Users;Cognitive Therapy;conditioned place preference;Data;design;Development;Dopamine;Dose;Drug Interactions;drug seeking behavior;Eating;Evaluation;exenatide;Experimental Designs;FDA approved;GLP-I receptor;glucagon-like peptide 1;Goals;Heart Rate;Human;improved;Laboratories;laboratory experiment;Laboratory Study;Legal;Maintenance;Mediating;Medical;Molecular Target;National Institute of Drug Abuse;novel;Nucleus Accumbens;Outcome;Outcome Measure;Participant;Persons;Pharmaceutical Preparations;Pharmacology Study;Pharmacotherapy;Phase II Clinical Trials;Physiological;Placebos;pre-clinical;preclinical study;primary outcome;Procedures;Psychological reinforcement;Public Health;Questionnaires;Randomized;Rodent;Safety;secondary outcome;Self Administration;Serum;social;Strategic Planning;subcutaneous;Testing;Therapeutic;Translational Research;treatment effect;Treatment Effectiveness;Treatment outcome;treatment strategy

PROJECT_TITLE: A Human Laboratory Study of Exenatide for Reducing the Reinforcing Effects of Cocaine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-A(02)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Eye Disease and Disorders of Vision;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Glaucoma is a leading source of vision loss worldwide and is frequently associated with elevated intraocular pressure (IOP). This study aims to investigate the actin cytoskeleton and extracellular matrix of normal and glaucomatous trabecular meshwork cells at two dynamic cellular structures important for regulating IOP. Results may provide new information about how normal eyes regulate IOP, while providing new avenues to explore to develop novel therapies to reduce elevated pressure in glaucoma patients.

PI_NAMEs: KELLER, KATE E (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Actin-Binding Protein;Actins;Affect;Anterior;Antibodies;aqueous;Aqueous Humor;Area;Automobile Driving;Binding;Biogenesis;Biological;Biological Assay;Blindness;CD44 gene;cell cortex;Cell membrane;Cell Physiology;Cell Shape;Cell surface;Cells;cellular imaging;Cellular Structures;Communication;Complex;Confocal Microscopy;Cytoskeleton;Data;extracellular;Extracellular Matrix;Extracellular Matrix Degradation;Eye;Filopodia;Funding;Gelatinase A;Genes;Glaucoma;Human;human tissue;In Situ;inhibitor;insight;Integral Membrane Protein;Integrins;kinase inhibitor;knock-down;Length;live cell imaging;Matrix Metalloproteinases;Measures;mechanical force;Mechanics;Membrane;membrane model;Modeling;Molecular;Molecular Conformation;Monitor;Myosin ATPase;Nanotubes;novel;novel strategies;novel therapeutics;Pathology;Pathway interactions;Patients;Perfusion;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphorylation;Physiologic Intraocular Pressure;Play;pressure;Proteins;receptor;Receptor Activation;Regulation;Research;Resistance;response;Rest;rho;rho GTP-Binding Proteins;Rho-associated kinase;Risk Factors;RNA Interference;Role;Site;Source;Stress Fibers;Stretching;Structure;Testing;therapeutically effective;Time;Tissues;Trabecular meshwork structure;ultra high resolution;Vesicle

PROJECT_TITLE: Extracellular Matrix and Outflow Resistance


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Long acting injectable Cabotegravir (CAB-LA) was recently approved for pre-exposure prophylaxis (PrEP) among at those at higher risk of HIV acquisition including pregnant and breastfeeding women. However, questions remain on the safety of this drugs during pregnancy and breastfeeding population. In this project, we aim to compare the safety of CAB-LA and oral TDF/FTC with respect to adverse pregnancy outcomes and infant development both through a surveillance registry of PrEP users who become pregnant and through an in-depth safety cohort.

PI_NAMEs: SAIDI, FRIDAY  (contact)

PROJECT_TERMS: Achievement;Address;Adherence;Adopted;Adverse event;adverse pregnancy outcome;Affect;Africa South of the Sahara;AIDS prevention;antenatal care;Anti-Retroviral Agents;antiretroviral therapy;Area;Birth;Birth Rate;Breast Feeding;Caregivers;Categories;Childhood;Classification;Clinical;cohort;Data;Device or Instrument Development;Diagnosis;District Hospitals;Drug usage;early childhood;emtricitabine;Enrollment;Ensure;Exposure to;Face;Female;fighting;follow-up;Fumarates;Goals;Grant;Growth;Growth and Development function;Health;high risk;HIV;HIV Infections;Human immunodeficiency virus test;Human Milk;implementation barriers;implementation science;improved;in utero;Incidence;Infant;Infant Development;Infant Health;infant infection;infant morbidity;infant morbidity/mortality;Infection;Injectable;Intervention;Lamivudine;Learning;Longitudinal Studies;Malawi;Maternal Exposure;Maternal Health;maternal safety;medication safety;Methods;Monitor;Mother-to-child HIV transmission;Mothers;Neurocognitive;Nutrition Assessment;Oral;Outcome;Parents;Perinatal;perinatal outcomes;Perinatal transmission;Pharmaceutical Preparations;Population;Postpartum Period;pre-exposure prophylaxis;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;prevent;programs;prospective;Registries;Reporting;Research Personnel;Risk;risk/benefit ratio;Safety;safety outcomes;Signal Transduction;Site;Small for Gestational Age Infant;Spontaneous abortion;stillbirth;Structure;System;Tenofovir;Time;United States Food and Drug Administration;Vertical Disease Transmission;Woman;Women's cohort;World Health Organization

PROJECT_TITLE: Project 1 - Surveillance and monitoring systems to identify strategies to improve perinatal practices [Parent Title: PREVENTING INFANT INFECTIONS WITH IMPLEMENTATION SCIENCE IN MALAWI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Food Allergies;Infectious Diseases;Nutrition;Prevention

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Gastrointestinal parasites are widely present in humans globally and may paradoxically drive both strong anti- parasite immune responses and prevent unwanted responses to self and environmental antigens through induction of tolerance mechanisms. We will use two parasitic infection models in mice that drive opposing Th1 or Th2 responses and ask how these anti-parasite T cell responses are generated by tracking parasite-specific T cells, and how they impact on responses to food antigens. These studies will provide novel and important insights into how parasites promote tolerogenic or pathogenic responses to gut antigens.

PI_NAMEs: EDELSON, BRIAN TODD (contact);HSIEH, CHYI S

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Address;Africa;Age;Allergens;Allergic Disease;Antigen Presentation;Antigens;Antiparasitic Agents;Autoimmune Diseases;Cause of Death;CD4 Positive T Lymphocytes;Cells;Child;Cholera Toxin;Chronic;cohort;Cryptosporidium;Data;Development;Diarrhea;diarrheal disease;dietary;Disease;Disparate;Effector Cell;effector T cell;Environment;Eragrostis;Experimental Models;Food;food antigen;Food Hypersensitivity;gastrointestinal;Generations;global health;gut colonization;helminth infection;Helminths;Homeostasis;Human;Hybridomas;Hygiene;Immune response;Immune Tolerance;immunopathology;in vivo;Incidence;Infection;insight;Interleukin-10;intestinal homeostasis;Intestinal parasite;Intestines;Knowledge;Laboratories;Maintenance;Modeling;Morbidity - disease rate;Mucosal Immune Responses;Mus;Nematospiroides dubius;novel;Oral;oral tolerance;Organism;Parasite Control;Parasites;Parasitic infection;pathogen;Pathogenicity;Pest Control;Phenotype;preservation;prevent;Prevention;Production;recurrent infection;Regulatory T-Lymphocyte;response;Risk;Rodent;Role;Sanitation;Small Intestines;Specificity;T cell response;T-Cell Development;T-cell receptor repertoire;T-Lymphocyte;Testing;Time;tool;transcription factor;Transgenic Mice;Transgenic Organisms;United States;Wild Type Mouse

PROJECT_TITLE: Role of Intestinal Parasites on Regulating Immune Responses to Gut Antigens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(57)]


ADMINISTERING_IC: DK

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: This project seeks to connect cellular function to gene expression during the maturation of human stem cell- derived islet organoids (SC-islets), with the goal of building better human models of islet development and physiology and new transplantation therapeutics for type 1 diabetes. To do so, it will develop (1) soft, stretchable tissue-embedded sensor arrays to chronically trace how individual endocrine progenitors develop, mature and form coordinated 3D islet networks; (2) tissue clearing and spatial-omics methods to map hormones, biomarkers, gene expression, and infer cell identity from intact SC-islets; and (3) computational methods to integrate single- cell functional and transcriptional data. Ultimately, these technologies will allow us to address major challenges for generating of functionally mature SC-islets for biomedical research and human therapeutics.

PI_NAMEs: LIU, JIA  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: 3-Dimensional;Address;Adult;Alpha Cell;autoimmune pathogenesis;Bar Codes;Beta Cell;Biological Markers;Biomedical Research;Blood Glucose;blood glucose regulation;Cell Differentiation process;Cell Physiology;cell type;Cells;Chronic;circadian;Coma;Computational Biology;Computing Methodologies;Custom;Data;Defect;Development;diabetic;Electronics;Endocrine;endocrine pancreas development;Film;functional loss;Gene Expression;Genetic Transcription;Glucagon;Glucose;Goals;Heterogeneity;Hormones;Human;human model;human stem cell-derived;Image;In Situ;In Vitro;in vivo;Individual;Injections;Insulin;Insulin-Dependent Diabetes Mellitus;invention;islet;Islet Cell;Islets of Langerhans;Kinetics;Label;Life;Life Expectancy;Maps;Mediating;Methods;Monitor;multimodality;nanoelectronics;Nerve;nerve supply;new technology;Organoids;Physiology;Positioning Attribute;progenitor;Resolution;Risk;Role;sensor;side effect;single-cell RNA sequencing;spatiotemporal;Stains;stem cell biology;stem cell population;Stem cell transplant;stem cells;success;Systems Biology;Technology;Therapeutic;Thinness;Tissue Embedding;Tissues;transcriptomics;Transplantation;Vascularization

PROJECT_TITLE: Charting human islet maturation via combined soft nanoelectronics and single-cell spatial transcriptomics


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Glaucoma is the second leading cause of blindness in the US and worldwide, and the only available treatment is reduction of intraocular pressure. Papilledema is optic nerve swelling caused by increased intracranial pressure, which has the potential to cause significant vision loss. Based on our promising pilot studies, we will develop and refine USVE for assessing glaucoma and papilledema as they are both dependent on the biomechanics of ocular tissues, including the posterior sclera surrounding the optic nerve head and USVE may have the ability to stratify the risk of glaucomatous damage and the propensity toward the development of papilledema and vision loss.

PI_NAMEs: CHEN, JOHN JING-WEI;SIT, ARTHUR J;ZHANG, XIAOMING  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Affect;Aftercare;Age;Back;Bilateral;biomechanical test;Biomechanics;Blindness;Characteristics;Clinic;Clinical;clinical biomarkers;cohort;Contralateral;Cornea;Data;Development;Diagnosis;Disease;disorder risk;Elastic Tissue;Elasticity;elastography;Enrollment;Eye;Eye diseases;Funding;Gender;Glaucoma;Grant;in vivo;Individual;Intracranial Hypertension;Knowledge;Measurement;Measures;Mechanics;Medical;Methods;Modeling;Modification;new therapeutic target;Normal Range;novel;Operative Surgical Procedures;Optic Disk;Optic Nerve;optic nerve disorder;Outcome;Papilledema;Pathogenesis;Patients;Physiologic Intraocular Pressure;Pilot Projects;pressure;Property;Pseudotumor Cerebri;recruit;Research;Resolution;Risk;Risk Factors;risk stratification;Role;Sclera;Severities;Speed;Swelling;Techniques;Tissues;ultrasound;viscoelasticity;Viscosity

PROJECT_TITLE: Noninvasive ultrasound vibro-elastography for assessing ocular disorders


NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE With improved HIV treatment outcomes for HIV-infected pregnant and breastfeeding women, an increasing proportion of new infant infections stem from incident maternal infections; in Malawi, one third of infant transmissions are due to HIV infections that are acquired during breastfeeding. Linking breastfeeding women to effective HIV prevention, specifically HIV pre-exposure prophylaxis (PrEP), is necessary to decrease postpartum HIV incidence, but PrEP uptake and persistent use has been limited by poor implementation of postpartum HIV testing and fragmented PrEP service delivery. In this project, we will evaluate an integrated postpartum prevention package intervention consisting of HIV testing, male partner engagement, integrated PrEP services, and community-based follow-up for defaulters, examining effects on PrEP uptake, persistence, and associated costs to inform HIV prevention programs and policies in sub-Saharan Africa.

PI_NAMEs: RUTSTEIN, SARAH E. (contact)

PROJECT_TERMS: Abstinence;Address;Adherence;Africa South of the Sahara;AIDS prevention;Appointment;Behavioral;Biological;Breast Feeding;budget impact;Caring;Childhood;Clinic;Cluster randomized trial;Communities;cost;cost effective;Cost Effectiveness Analysis;Counseling;Cross-Sectional Studies;Data;Diagnostic Reagent Kits;Dose;effectiveness evaluation;effectiveness outcome;Eligibility Determination;female reproductive tract;follow-up;Formulation;Goals;Guidelines;Health;Health care facility;high risk;HIV;HIV Infections;HIV risk;HIV Seronegativity;Hormonal;Human immunodeficiency virus test;Hybrids;Immunization Programs;implementation outcomes;implementation science;implementation strategy;implementation/effectiveness;Improve Access;improved;Incidence;incremental cost;Infant;infant infection;Infection;Injectable;International;Intervention;intervention cost;Interview;Late pregnancy;Link;Malawi;male;Measures;Methods;microcosting;Modeling;Mothers;novel;Oral;Outcome;Parents;Partner Notification;Patient Self-Report;Patients;pediatric human immunodeficiency virus infection;peer;perinatal HIV;Perinatal transmission;Persons;Pharmacy facility;Physiological;Policies;Policy Maker;post implementation;Postpartum Period;Postpartum Women;pre-exposure prophylaxis;Pregnancy;pregnant;premature;prevent;Prevention;Prevention program;primary outcome;Proctor framework;programs;prospective;Provider;Randomized;Recommendation;Research Personnel;Risk;Risk Assessment;scale up;screening;secondary outcome;self testing;seroconversion;service delivery;Services;sex;Sex Behavior;Site;standard of care;stem;synergism;Testing;theories;Time;tool;Training;transmission process;treatment arm;Treatment outcome;Unsafe Sex;uptake;Vaccination;Vertical Disease Transmission;Visit;Woman

PROJECT_TITLE: Project 2 - Improving HIV prevention among postpartum women in Lilongwe, Malawi: the postpartum prevention package [Parent Title: PREVENTING INFANT INFECTIONS WITH IMPLEMENTATION SCIENCE IN MALAWI]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE Normal brain function depends on the orderly development of circuits in the cerebral cortex and on their intact function. Knowledge of the normal circuitry provides a foundation for understanding the causes of impaired brain function and developing corrective measures. Our studies of the normal circuitry between early visual cortical areas will provide greater insight into the causes and effects of central vision defects when these circuits are damaged by stroke or other neurological or developmental cause. In particular, our studies of feedback circuits between different visual cortical areas will help our understanding of how these pathways mediate the influence of stimulus context on neuronal responsivity, spatial integration, and changes in visual sensitivity associated with top-down attention. Moreover, understanding how these circuits operate in normal vision will provide a foundation for understanding the consequences of their dysfunction in neurological and psychiatric disorders, such as autism, schizophrenia and attention deficits disorders, which have been directly linked to abnormalities in inter-areal connectivity [e.g. Belmonte et al. J. Neurosci. (2004) 24:9228-9231; Lynall et al. J. Neurosci. (2010) 30:9477-9487].

PI_NAMEs: ANGELUCCI, ALESSANDRA  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Affect;Algorithms;Anatomy;Area;area V1;area V2;Attention;Attention Deficit Disorder;Attentional deficit;autism spectrum disorder;Automobile Driving;base;Biological Models;Brain;brain dysfunction;cell type;Cells;Cerebral cortex;Code;Color;Complex;cytochrome c oxidase;Defect;density;design;Development;Disease;extrastriate visual cortex;Feedback;Foundations;Functional disorder;Funding;Goals;Human;insight;Investigation;Knowledge;Label;Link;Maps;Measures;Mediating;Mental disorders;Methods;Modeling;Motion;Neocortex;Nervous System Disorder;Neurologic;Neurons;Noise;nonhuman primate;novel;optical imaging;optogenetics;Output;Pathway interactions;Primates;Probability;Property;Rabies virus;receptive field;Research;response;Role;Schizophrenia;segregation;sensory cortex;Shapes;Signal Transduction;spatial integration;Stimulus;Stream;Stroke;Structure;System;Target Populations;Testing;tool;V1 neuron;V2 neuron;Viral;Vision;Visual;Visual attention;Visual Cortex;Visual evoked cortical potential;visual stimulus;Visual System;Visuospatial;Work

PROJECT_TITLE: Anatomical and functional organization of inter-areal feedback circuits in the visual cortex, and their impact on neuronal responses

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: At least more than one million individuals may have suffered a mild traumatic brain injuries (mTBIs) in the US in any single year, and the long term neurological consequences are devastating. Our proposal focuses on the molecular intersection of mild TBI with neuropathological signs of dementia. Given our expertise in the molecular pathways converging on the endoplasmic reticulum, we are optimally position to successfully complete the proposed work and identify novel therapeutic intervention strategies.

PI_NAMEs: ABISAMBRA, JOSE FRANCISCO (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Adopted;Affect;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Animals;Area;Biological Markers;Blood;Brain;brain cell;brain dysfunction;Brain Injuries;brain parenchyma;Cell Death;cell type;Cessation of life;Chemicals;Chronic;Clinical;Closed head injuries;Cognitive;cognitive benefits;cognitive testing;cohort;Craniocerebral Trauma;Data;Dementia;Deposition;Disease;Electrophysiology (science);Endoplasmic Reticulum;endoplasmic reticulum stress;Event;experimental study;Functional Magnetic Resonance Imaging;genetic manipulation;Grant;high risk;Hyperactivity;Image;imaging approach;Immunohistochemistry;Impaired cognition;In Vitro;in vivo;in vivo evaluation;Individual;inhibitor;injured;Injury;Intervention;Link;Magnetic Resonance Imaging;Manganese;Measures;Mediating;mild traumatic brain injury;Modeling;Molecular;Molecular Conformation;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;Neurologic;Neuronal Dysfunction;neuropathology;neurotoxic;new therapeutic target;non-invasive imaging;novel;novel marker;novel therapeutic intervention;Outcome Measure;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Persons;Positioning Attribute;Predisposition;prevent;primary outcome;Production;protective pathway;protein aggregation;Protein Biosynthesis;Proteins;Proteomics;Recording of previous events;recruit;repository;Research;Resistance;Resources;secondary outcome;sensor;Serum;Severities;Signal Transduction;stem;Surveys;tau aggregation;tau Proteins;Tauopathies;Techniques;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Time;tissue degeneration;Tissues;Transgenic Mice;translatome;Traumatic Brain Injury;United States;Viral;Wild Type Mouse;Work

PROJECT_TITLE: The molecular intersection of tau, TBI, and PERK

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD-M]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Globally, entrenched barriers to HIV testing for infants and young children exposed to HIV have left more than two-fifths of children living with HIV undiagnosed and one-half without access to life-saving antiretroviral therapy, perpetuating a widening treatment gap between adults and children living with HIV. To address this glaring gap, and optimize HIV treatment for the mothers of these infants and young children, we have developed a new and integrated differentiated service delivery model, coined PAC-Man, to bring a package of evidence-based elimination of mother-to-child transmission (EMTCT) of HIV services out of the clinic and into the community for mother-infant pairs at the highest risk for poor HIV outcomes. In this project, we will use established implementation science theories, strategies, and outcomes to integrate the PAC-Man model into routine HIV care settings in Malawi, and rigorously evaluate the model using a pragmatic, stepped-wedged trial design in hopes of demonstrating its impact for use in real-world EMTCT programs in sub-Saharan Africa.

PI_NAMEs: HERCE, MICHAEL EMMANUEL (contact)

PROJECT_TERMS: Address;Adoption;Adult;Africa South of the Sahara;Age;antiretroviral therapy;Back;Breast Feeding;care systems;Caring;case finding;Case Management;Child;Childhood;Clinic;Coin;Communities;cost;Country;Data;diagnostic platform;Drops;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness/implementation hybrid;Enrollment;evidence base;Evidence based practice;Exposure to;Failure;field survey;Funding;Guidelines;Health care facility;Health Services;Health system;high risk;HIV;HIV diagnosis;Human immunodeficiency virus test;Immunization;implementation outcomes;implementation science;implementation strategy;Improve Access;Infant;infant infection;Intervention;Left;Life;Location;Malawi;maternal outcome;Methods;Modeling;Monitor;mortality;Mother-to-child HIV transmission;Mothers;Newly Diagnosed;novel;Outcome;Outpatients;Parents;pediatric human immunodeficiency virus;point of care;point-of-care diagnostics;poor health outcome;Population;Pregnancy;pregnant;prevent;primary outcome;programs;Random Allocation;Randomized;Recommendation;Risk;Sampling;screening;Series;Service delivery model;Services;Site;standard of care;Subgroup;Technology;Testing;theories;trial design;uptake;Vertical Disease Transmission;Viral;Viral Load result;Woman;Zambia

PROJECT_TITLE: Project 3 - Point-of-care Active Case finding & Management (PAC-Man) Model [Parent Title: PREVENTING INFANT INFECTIONS WITH IMPLEMENTATION SCIENCE IN MALAWI]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pancreatic Cancer;Prevention;Rare Diseases

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE Screening for the early detection of pancreatic ductal adenocarcinoma and its precursors requires tests which are sensitive, feasible, and acceptable to a wide population base while easily administered outside of high- volume referral centers. The OHSU Research Unit proposes two complementary approaches to screening, one using a novel extracellular vesicle-based assay that can be obtained rapidly and with very low blood volumes, and a second that modifies standard magnetic resonance imaging techniques to detect subtle evidence of focal fibroinflammatory changes in the pancreas, a common feature of pancreatic intraepithelial neoplasia, using a quantitative technique called magnetic resonance fingerprinting.

PI_NAMEs: COTE, GREGORY A;GUIMARAES, ALEXANDER SAVIO RAMOS;SEARS, ROSALIE C (contact);SHEPPARD, BRETT C

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Address;Atrophic;Awareness;Biological Assay;Biological Markers;biomarker validation;biomedical referral center;Biopsy;Blood;Blood Volume;Body Fluids;Cancer Biology;Case/Control Studies;chronic pancreatitis;Circulation;Clinic;Clinical;Clinical Trials;cohort;Collaborations;community engagement;Community Outreach;Complex;Consumption;Contrast Media;Cyst;Data;design;Detection;Diagnosis;Diagnostic;dielectric property;Duct (organ) structure;Early Diagnosis;early screening;Eligibility Determination;Enrollment;Ensure;Excision;extracellular vesicles;FDA approved;Fibrosis;Fingerprint;Focus Groups;Gadolinium;Genetic;High grade dysplasia;high risk;high risk population;Home;Hydrogels;Image;imaging biomarker;imaging modality;imaging science;Imaging Techniques;implementation science;Inflammation;innovation;Interobserver Variability;Interview;Lesion;Liquid substance;Longitudinal Studies;Machine Learning;Magnetic Resonance;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Measures;member;Methods;Microelectrodes;Microfluidic Microchips;minority communities;Mission;Modeling;Molecular;Morphology;Mucinous Neoplasm;multidisciplinary;nanoparticle;novel;Oregon;outreach;Pancreas;pancreas imaging;Pancreatic Ductal Adenocarcinoma;Pancreatic Intraepithelial Neoplasia;Papillary;participant enrollment;patient engagement;Patient Participation;Patients;Pattern;Phase;phase 3 study;Plasma;Population;population based;programs;Protocols documentation;recruit;Reproducibility;Research;Resources;risk stratification;Rural Minority;Sampling;Science;screening;Screening for cancer;Screening procedure;Source;Techniques;Testing;Time;tissue registry;Tissue Sample;tumor;Underrepresented Minority;Underrepresented Populations;Validation;volunteer;Work

PROJECT_TITLE: Validation of novel imaging and molecular tests for early detection of pancreatic cancer through risk-stratified community engagement programs


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE We must better understand cortical and thalamic circuitry and thalamocortical/corticothalamic relationships to follow information flow and other aspects of thalamic and cortical functioning. This fundamental information may be a prerequisite to understanding and better dealing with a number of cognitive defects, like schizophrenia, Alzheimer's, etc.

PI_NAMEs: KASTHURI, NARAYANAN ;SHERMAN, S. MURRAY  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Abbreviations;Address;Alzheimer's Disease;Anatomy;Anterior;Area;ascorbate;Attention;Auditory area;Automobile Driving;Axon;Brain;Brain region;Catalogs;Cell Nucleus;cell type;Cells;Cellular Morphology;Characteristics;Classification;Cloning;Cognitive deficits;Complex;Comprehension;connectome;Cytoplasm;Data;Data Set;Dendrites;Dependovirus;Dorsal;Electron Microscope;Electrons;Engineering;Excitatory Postsynaptic Potentials;falls;flexibility;Future;Genetic;Geniculate body structure;Glutamates;Goals;hippocampal pyramidal neuron;image reconstruction;Individual;Injections;interest;Interneurons;Knowledge;Label;Lateral;Lateral Dorsal Nucleus;Lateral Geniculate Body;Lateral posterior nucleus of thalamus;Learning;Maps;Medial;Metabotropic Glutamate Receptors;Methods;Microscopic;Mitochondria;Modeling;Morphology;Motor Cortex;Mus;Nature;neuroimaging;Neurons;Nuclear;Pathway interactions;Pattern;Peroxidases;Physiological;Population;Property;Pulvinar structure;Research;Retina;retinal axon;Rodent;Schizophrenia;Somatosensory Cortex;Source;Stream;Structure;Synapses;Techniques;Terminology;Testing;Thalamic Nuclei;Thalamic structure;tool;vector;Ventral Posterior Nucleus;Vertebral column;Vesicle;virtual;Visual Cortex

PROJECT_TITLE: Connectome of circuits within and between thalamus and cortex


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE. Leakage of the tricuspid valve, which is located between the right atrium and right ventricle, is extremely common and, if not treated, can significantly impact the health of patients. The current gold-standard for treatment is a surgical approach known as tricuspid annuloplasty, which unfortunately does not have high long-term success rates and fails in approximately one third of patients. This proposal is relevant to public health as we aim to better understand a new tricuspid valve disease mechanism, tricuspid valve maladaptation, that could be used as future therapeutic target toward improving the currently poor outcomes for patients with tricuspid valve regurgitation.

PI_NAMEs: RAUSCH, MANUEL KARL (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Acute;American;Animals;Area;Benefits and Risks;Biological;Chronic;clinically relevant;Computer Simulation;Death Rate;Dilatation - action;Disease;experience;Extravasation;Fibrosis;Future;Growth;Health;Heart;Heart Valve Diseases;high risk;Human;Image;Implant;improved;In Vitro;Individual;innovation;Intervention;journal article;Knowledge;Measures;Mechanics;member;minimally invasive;Morbidity - disease rate;mortality;new therapeutic target;Operative Surgical Procedures;Outcome;Pathologic;patient population;Patient-Focused Outcomes;Patients;Phenotype;prophylactic;Public Health;Pulmonary Hypertension;Recording of previous events;Recurrence;repair strategy;Repeat Surgery;Right atrial structure;right ventricular remodeling;Right ventricular structure;Sheep;sheep model;Speed;standard care;Stimulus;success;Techniques;Testing;Therapeutic;therapeutic target;Thick;Three-Dimensional Imaging;Tissues;treatment response;Tricuspid Valve Insufficiency;Tricuspid valve structure;Ultrasonics;Visualization;Work

PROJECT_TITLE: Tricuspid Valve Maladaptation: Its Stimuli, its Effect on Valve Function, and its Response to Therapy

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative  Effective diagnosis and treatment of depression in people living with HIV (PWH) is a critical public health issue, and HIV infection and depression may act through common myeloid mechanisms to exacerbate behavioral and functional changes. Outlined in this K01 application is a multifaceted series of experiments designed to investigate the effects of in vivo and in vitro antidepressants on viral dynamics and inflammation in peripheral and CNS myeloid cells in multiple models (clinical cohorts of PWH and iPSC-derived mono and co-cultures). These studies will significantly advance our understanding of the antidepressant-mediated cellular mechanisms in HIV neuropathogenesis, guiding personalized medication in depressed PWH, and this opportunity will provide comprehensive training and a solid foundation on which to build a successful and independent research program.

PI_NAMEs: MATT, STEPHANIE MARIE (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Acceleration;Affect;Agonist;anti-depressive agents;antidepressant effect;antiretroviral therapy;Behavioral;Biometry;biotypes;Bupropion;career;career development;Cells;Chronic;chronic infection;Clinical;Coculture Techniques;cognitive function;cohort;Collection;combinatorial;comorbidity;Complex;cytokine;Data;Depressed mood;depressive symptoms;design;Development;Diagnosis;Disease Progression;Drug usage;efficacious treatment;Environment;Experimental Designs;Foundations;Genetic Transcription;Glutamates;Goals;Health;HIV;HIV Infections;Human;Image;Immune;immunoregulation;Impaired cognition;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inflammation;Inflammatory;Institution;Investigation;Knowledge;Laboratories;Link;Macrophage;Mediating;Mental Depression;Mentored Research Scientist Development Award;Mentors;Messenger RNA;Microglia;Modeling;monocyte;Myelogenous;Myeloid Cells;Neurobehavioral Manifestations;neuroimmunology;Neurologic;Neurons;Neuropathogenesis;neuropsychiatry;Neuropsychological Tests;neurotransmission;Neurotransmitter Receptor;Neurotransmitters;NF-kappa B;novel;Nuclear Translocation;Pathogenesis;Pathology;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Plasma;Population;programs;Psychoneuroimmunology;Public Health;Quality of life;receptor;Receptor Activation;Regimen;Research;Research Personnel;Residual state;Resistance;Role;Sampling;Series;Signal Transduction;skills;Solid;Techniques;Testing;therapy adherence;therapy resistant;Time;Training;Treatment Efficacy;treatment-resistant depression;Viral;Viral reservoir

PROJECT_TITLE: The role of antidepressants in central and peripheral myeloid HIV persistence and inflammation

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Cardiovascular;Chronic Pain;Heart Disease;Neurosciences;Pain Research

ORG_CITY: NEW YORK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Narrative This project seeks to understand how the activity of tandem pore (K2P) potassium channels is modulated within the cell. K2P channels have been implicated as possible targets for treatment of several diseases, including chronic pain, arrhythmia, and depression, though there are currently no medications that primarily target K2Ps. We aim to investigate the ways in which K2P channel activity is modulated, in the hope that these findings will uncover avenues to develop drugs that target this ion channel family.

PI_NAMEs: RIEGELHAUPT, PAUL MICHAEL (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Address;Affect;Affinity;Architecture;Arrhythmia;Behavior;Binding Sites;Biological Assay;Biology;Biophysics;Blood Vessels;Cardiac;Cells;chronic pain;chronic pain management;clinical practice;Combinatorics;Cryoelectron Microscopy;Crystallization;Cues;Data;design;Detergents;Development;Disease;drug development;Drug Targeting;Eicosanoids;Electrodes;Electrophysiology (science);Endocrine;Environment;experimental study;Family;Goals;Human;improved;in vivo;Individual;Ion Channel;Ions;Knowledge;Lipid Binding;Lipids;Mass Spectrum Analysis;Measures;mechanical force;Mechanics;Membrane;Membrane Potentials;Mental Depression;Modeling;Molecular;Molecular Conformation;Movement;mutant;Mutate;mutation screening;nanodisk;Neurons;Nonesterified Fatty Acids;novel;Output;particle;patch clamp;Pharmaceutical Preparations;Pharmacology;Phospholipids;Physiological;Physiology;Play;Potassium;Potassium Channel;potassium ion;protein reconstitution;proteoliposomes;Regulation;Research;Resolution;response;Rest;Role;Signal Transduction;Site-Directed Mutagenesis;small molecule;Specificity;Stretching;Structural Models;Structure;Temperature;Therapeutic;Therapeutic Agents;tool;Transmembrane Domain;voltage clamp;X-Ray Crystallography

PROJECT_TITLE: Molecular mechanisms of Tandem Pore potassium channel gating and regulation

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Dietary Supplements;Eye Disease and Disorders of Vision;Macular Degeneration;Natural Products;Neurodegenerative;Neurosciences;Nutrition;Prevention

PHR: Project Narrative Carotenoids such as lutein and zeaxanthin are probably the safest and most cost-effective nutrients available to prevent retinal disease such as age-related macular degeneration (AMD), but their incorporation into practice sometimes precedes basic and clinical support for their usage. The results of our studies will advance mechanistic knowledge of their physiological functions at a molecular level, which will enable basic studies that account for their roles in retinal neuroprotection, as well as clinical studies that will lead to rational, scientifically supported decisions about treatments to prevent visual loss throughout a person’s lifetime.

PI_NAMEs: BERNSTEIN, PAUL STEVEN (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: adeno-associated viral vector;age related;Age related macular degeneration;Animal Model;ATP binding cassette transporter 1;Basic Science;Binding Proteins;Biochemical;Biochemistry;Biological Assay;Blindness;Carotenoids;Carrier Proteins;Cells;Child Development;Clinical;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;Complex;cost effective;Data;Dedications;Deposition;Development;Diet;dietary;Dietary Intervention;Disease;Drusen;Elderly;Enzymatic Biochemistry;Enzymes;experimental study;Eye;Eye diseases;Fluorescence Microscopy;fovea centralis;Future;Genetically Engineered Mouse;Goals;Grant;GSTP1 gene;HDL receptor;Health;Health Promotion;High Density Lipoprotein Cholesterol;Human;Image;imaging study;Imaging Techniques;Immunohistochemistry;In Situ;in vivo;Individual;Infant formula;innovation;insight;Intervention;intravitreal injection;Isomerase;Isomerism;Knowledge;Laboratories;Laboratory Research;Lasers;life span;Light;Lutein;macula;Mediating;meso-zeaxanthin;Metabolic;Metabolism;Methods;Microscope;Microscopy;Molecular;mouse model;Mus;Mutagenesis;Nature;neuroprotection;next generation;novel;Nutrient availability;overexpression;oxidative damage;Pathway interactions;Patients;Persons;Pharmacology;Physiological;Physiology;Pigments;prenatal;prevent;Primates;Probability;Protein Biochemistry;protein biomarkers;Proteins;Raman Spectrum Analysis;randomized, clinical trials;Research;Resolution;Retina;Retinal Diseases;Retinal macula;Role;RPE65 protein;Site-Directed Mutagenesis;Spatial Distribution;SR-BI receptor;standard of care;structural biology;Supplementation;Testing;Tissues;Transgenic Organisms;translational impact;United States;uptake;Vision;Visual System;Wild Type Mouse;Xanthophylls;zeaxanthin

PROJECT_TITLE: Biochemistry and Pharmacology of the Macular Carotenoids

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Majority of patients who are resuscitated from sudden cardiac arrest have poor neurological outcomes. Although virtually all comatose post-cardiac arrest patients are sedated after successful cardiopulmonary resuscitation, the effects of sedation on the brain function of post-arrest patients are unknown. This study will seek to elucidate the effects of post-cardiac arrest sedation on recovery of brain function using advanced electrophysiological and genetic tools in male and female mice subjected to experimental cardiac arrest.

PI_NAMEs: ICHINOSE, FUMITO  (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Address;Adopted;Adult;Adult women;Anesthesia procedures;Anesthetics;Attenuated;Biological Markers;Brain;Brain Injuries;Brain Ischemia;Cardiopulmonary Resuscitation;Caring;Cause of Death;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Circulation;Coma;Dexmedetomidine;Electroencephalography;Electrophysiology (science);Encephalopathies;Exclusion;Female;Genetic;Guidelines;Heart Arrest;Hospitals;Hyperemia;Hypothalamic structure;improved;Infusion procedures;innovation;Intravenous infusion procedures;Ketamine;Knowledge;male;Metabolic;Metabolism;Methods;Mus;natural hypothermia;Nervous System Trauma;neural;Neurological outcome;neurological recovery;Neurons;neurophysiology;neuroprotection;Outcome;Patients;Physiological;poor sleep;prevent;Prevention;Propofol;Publishing;Recovery;Role;Sedation procedure;Sleep;sleep quality;Slow-Wave Sleep;Survival Rate;Temperature;Testing;tool;virtual;Withdrawing Care

PROJECT_TITLE: Role of Sedation in the Post-Cardiac Arrest Neurological Recovery

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Genetics;Human Genome;Precision Medicine;Prevention;Social Determinants of Health

PHR: Project Narrative This proposal aims to characterize gene-environment interactions (i.e., genetic effects modified by environment) underlying complex traits in humans. We will develop statistical tests to identify historical genetic responses to the Agricultural Revolution during human evolution, which will inform our understanding and study of the current epidemics of complex diseases because they are likely results of gene-lifestyle mismatches. We will develop computational tools and perform large-scale empirical analysis in large population cohorts to characterize gene-environment interactions, to prioritize actionable environmental exposures for clinical intervention, and to improve genetic prediction for precision medicine.

PI_NAMEs: YE, KAIXIONG  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Agriculture;Attenuated;biobank;bioinformatics tool;Clinical;cohort;Complex;computational pipelines;computerized tools;Coupled;Data;Databases;Dedications;Disease;DNA;Environment;Environmental Exposure;Environmental Risk Factor;Epidemic;Etiology;Evolution;Future;gene environment interaction;Genes;Genetic;genetic architecture;genetic epidemiology;genetic predictors;Genetic Risk;genetic variant;Genetic Variation;Genome;genome wide association study;Human;human disease;improved;insight;Intervention;Life Style;Measures;Mendelian randomization;Meta-Analysis;Methods;novel;Outcome;Pattern;phenome;Phenotype;Polygenic Traits;Population;portability;precision medicine;Research;Resources;response;Role;Shapes;Statistical Models;statistics;Subgroup;Testing;tool;trait;web site

PROJECT_TITLE: Gene-Environment Interactions in Human Evolution and Complex Traits

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: ORANGE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: CHAPMAN UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative People post-stroke retain the capacity to modify walking patterns explicitly using biofeedback and implicitly when encountering changes in the walking environment. This proposal will assess changes in muscle activation patterns associated with walking modifications driven explicitly vs. implicitly, to determine whether individuals generate different amounts of co-contraction during explicit vs. implicit walking modifications. Understanding how walking modifications driven explicitly vs. implicitly influence co-contraction will allow us to identify approaches that can more effectively restore muscle activation toward pre-stroke patterns, promoting mechanism-based recovery of walking function.

PI_NAMEs: SANCHEZ, NATALIA  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Age;Agonist;antagonist;Awareness;Behavior;Biofeedback;Brain Stem;Chronic;Clinical;clinical decision-making;Clinical Trials;comparison control;Compensation;Cues;Data;design;Disabled Persons;Educational Intervention;Environment;Foundations;Future;Gait abnormality;gait rehabilitation;Generations;Goals;hemiparetic stroke;Impairment;indexing;Individual;insight;Interruption;Intervention;Joints;kinematics;Kinetics;Length;Lesion;Lower Extremity;Measures;Mediating;Modification;Motor;motor control;motor impairment;Movement;Muscle;Nervous System Trauma;neural;Neural Pathways;neuroimaging;neuromuscular;neuroregulation;novel strategies;Participant;Pathway interactions;Pattern;Persons;post stroke;primary outcome;Protocols documentation;Recovery;Rehabilitation therapy;Research;Research Priority;Residual state;Resources;response;restoration;Speed;Stroke;stroke survivor;Testing;therapy design;Time;Torque;Training;treadmill;treatment response;verbal;Visual;Walking;walking intervention;walking rehabilitation;Work

PROJECT_TITLE: Determining the effects of increased demands for voluntary adjustments on the neuromuscular control of walking post-stroke


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Organ Transplantation;Transplantation

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Liver transplantation is the standard treatment for end-stage liver disease; yet, many procured livers are discarded due to ischemia-reperfusion injury (IRI), perpetuating a vast donor shortage that increases waitlist times and patient mortality. This proposal seeks to utilize small RNA drugs to silence known mediators of IRI in liver grafts during the transplantation process. Findings from this study will inform the development of therapies that increase the number of viable liver grafts, saving the lives of thousands of liver disease patients.

PI_NAMEs: BUCHWALD, JULIANNA E (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Acetylgalactosamine;Affect;Apoptosis;Biochemical Markers;Blood Vessels;CD95 Antigens;Cell Death;cell injury;Cessation of life;Chemicals;Chemistry;Clinical;Closure by clamp;Cryopreservation;cytokine;design;end stage liver disease;Euthanasia;experimental study;FDA approved;Gene Expression;Genes;Goals;Hepatic Tissue;Hepatocyte;Histology;Hour;Human;implantation;improved;In Vitro;in vivo;in vivo imaging;Individual;Inflammation;Inflammatory;Inflammatory Infiltrate;innate immune pathways;Innate Immune Response;Ischemia;knock-down;Liver;Liver diseases;Liver Dysfunction;Liver Failure;liver function;liver inflammation;liver injury;liver ischemia;liver preservation;liver transplantation;Measures;Mediating;Mediator;Messenger RNA;Modeling;mortality;Necrosis;Neutrophil Infiltration;Organ;Outcome;oxidative damage;Oxidative Stress;Pathology;Pathway interactions;Patients;Perfusion;Pharmaceutical Preparations;preservation;Process;Proteins;Rattus;receptor;Reperfusion Injury;Reperfusion Therapy;response to injury;siRNA delivery;Small Interfering RNA;Small RNA;standard care;subcutaneous;Technology;Testing;therapy development;Traction;Transaminases;transcriptome;transcriptome sequencing;Transplantation;uptake;Waiting Lists

PROJECT_TITLE: Investigating siRNA-mediated inhibition of ischemia-reperfusion injury during the liver transplantation process


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Radiation Oncology

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative: The proposed research aims to develop and translate a novel 3D prompt gamma imaging system for in-vivo dose verification of proton radiotherapy. This technique would allow us to image the actual in-vivo proton beam range and dose distribution delivered during treatment. Such capabilities would allow for monitoring of the accuracy of treatment delivery (via measured changes to the delivered beam range/dose) on a daily basis, providing a means to ensure proper dose delivery is maintained over the course of treatment, thus minimizing the negative effects that current range uncertainties have on treatment delivery.

PI_NAMEs: POLF, JERIMY C.;REN, LEI  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: 3-Dimensional;Address;Anatomy;Award;Brain;Calibration;Cancer Patient;Cell Nucleus;Characteristics;Clinical;clinical translation;Collaborations;Computer software;computerized data processing;Data;Deposition;Detection;Development;Dose;Ensure;Funding;Gamma Rays;Goals;Grant;Image;image guided;image processing;image reconstruction;imaging modality;imaging system;improved;in vivo;in vivo imaging system;Industry;industry partner;innovation;Inpatients;Lead;Legal patent;Location;Maps;Maryland;Measures;Methods;Monitor;Morphologic artifacts;Normal tissue morphology;novel;Patients;Pelvis;Photons;Pilot Projects;prevent;Procedures;Process;Prostate Cancer therapy;prostate radiotherapy;proton beam;Proton Radiation;Protons;prototype;Publications;quality assurance;Radiation;Radiation therapy;rapid growth;Rectum;Research;Signal Transduction;simulation;success;System;Techniques;therapy development;Three-Dimensional Image;Tissues;Toxic effect;Translating;Translations;Treatment Efficacy;tumor;Uncertainty;United States National Institutes of Health;Work

PROJECT_TITLE: 3-dimensional prompt gamma imaging for online proton beam dose verification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-S(57)R]


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Cataracts remain as the leading cause of blindness in the world. Lens transparency relies on a bulk of elongated and interlocked fiber cells, coupled into a syncytial unit by gap junctions. This project will elucidate the gap knowledge about the mechanistic regulation of fiber cell interlocking structures including protrusions and ball-and-sockets and lens calcium homeostasis. This project will further identify novel genetic variances that are essential for the formation and maintenance of lens transparency throughout lifetime.

PI_NAMEs: GONG, XIAOHUA  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Adhesions;Aging;Biochemical;Biological;Blindness;Calcium;Calcium Channel;Calpain;Cataract;Cell Maturation;Cell Nucleus;Cells;Chromosome 2;Circulation;Communities;Complex;Connexins;Coupled;Cytoskeleton;Equilibrium;F-Actin;Fiber;fiber cell;functional loss;gain of function;Gap Junctions;Genes;Genetic;Genetic Models;Genetic Variation;Homeostasis;Knock-out;Knockout Mice;Knowledge;lens;lens cortex;Lens Fiber;lens transparency;Link;Maintenance;Mediating;Membrane;Methods;MIP gene;Modeling;Morphogenesis;mosaic;mouse genetics;Mouse Strains;Mus;mutant;novel;Nuclear;Other Genetics;Pathologic;periaxin;postnatal;prevent;protein degradation;Regulation;Research;Research Project Grants;Research Proposals;Scaffolding Protein;Severities;Shapes;Side;Stress;Structure;Surface;System;Testing

PROJECT_TITLE: Cataractogenesis, Connexin Mutants and Genetic Modifier(s)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Z(02)M]


ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative The proposed work aims to develop better anti-adhesions surgical sealants utilizing local release anti- inflammatory oligopeptides from biodegradable polymers by site specific deposition. This approach has the propensity to be a potent tool in surgery and general biomaterials fabrication. The goal of this research is to correlate material properties to in vitro and in vivo surgical sealant efficacy, leading to progress over existing clinical treatment options and improved procedural outcomes.

PI_NAMEs: KOFINAS, PETER  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Abdomen;Abdominal Cavity;Acute;Adherence;Adhesions;Adopted;Adsorption;Affinity;Agonist;Anastomosis - action;Animal Model;Animals;Anti-Inflammatory Agents;Antiinflammatory Effect;Apolipoprotein E;Apolipoproteins;Appearance;Area;Biocompatible Materials;biodegradable polymer;Biological;biomaterial compatibility;Blood Proteins;Carboxymethylcellulose;Cholesterol Homeostasis;Chronic;chronic pelvic pain;Cicatrix;Clinical;clinical translation;Clinical Treatment;Clinical Trials;Coagulation Process;combinatorial;Complication;controlled release;cytokine;Data;Deposition;design;Development;efficacy evaluation;Elasticity;elastomeric;Elastomers;Exhibits;Extravasation;fabrication;Female infertility;Fiber;Fibrin;Fibroblasts;fibrogenesis;Film;Foundations;Gel;Glycolates;Goals;Health Care Costs;Hemostatic Agents;holistic approach;Human;Hyaluronic Acid;Implant;improved;In Vitro;in vivo;Inflammatory;Inflammatory Response;injured;Injury;Intestinal Obstruction;Intestines;intraperitoneal;Ischemia;Kinetics;Ligation;lipid transport;Lipoproteins;Liquid substance;Measures;mechanical properties;Mesothelium;Modeling;Molecular Weight;mouse model;Mus;novel;Oligopeptides;Operative Surgical Procedures;Organ;Outcome;Pathology;Pathway interactions;peptidomimetics;Peritoneal;Pharmaceutical Preparations;Polymers;porcine model;Postoperative Period;preclinical efficacy;preclinical evaluation;pressure;prevent;Prevention;prevention evaluation;Prevention strategy;Proliferating;Property;Protein Isoforms;Proteins;Qualifying;receptor binding;Research;Safety;Scheme;seal;sealant;Severities;Site;Small Intestines;Solid;success;Surface;System;targeted treatment;Techniques;therapeutic target;Time;Tissues;tool;Topical application;translational barrier;Trauma;Treatment Efficacy;Work;wound;wound healing

PROJECT_TITLE: Sprayable Polymer Blends for Prevention of Site Specific Surgical Adhesions


PHR: Project Narrative The proposed research is relevant to public health, as well as the mission of NIHLBI, because it will ultimately inform treatment options to decrease the risk of having an adverse cardiovascular event during physical activity in individuals with T1D. Upon successful completion of the proposed project, we expect our contribution to be an initial understanding of possible interactive mechanisms responsible for evoking exaggerated blood pressure responses in those with T1D, and whether sex differences play a role.

PI_NAMEs: STONE, AUDREY J (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: Affect;arm;ASIC channel;Attenuated;Autonomic Dysfunction;Axon;Biochemical;Blood flow;Blood Pressure;blood pressure elevation;Cardiovascular Diseases;Cardiovascular system;Cessation of life;Circulation;Contracts;Dangerousness;Data;diabetic rat;Disease;Disease Progression;Electrophysiology (science);Event;Evolution;Exercise;Female;Functional disorder;Goals;Health;Heart Rate;Hindlimb;Hyperglycemia;Immunohistochemistry;improved;in vivo;Individual;innovation;Insulin-Dependent Diabetes Mellitus;Knock-out;Location;male;Measures;Mechanics;Metabolic;Mission;Modeling;mortality;Muscle;Muscle Contraction;Muscle Fibers;Myocardial Infarction;Nerve Endings;neural;Neurons;Outcome;Oxygen;Pattern;Persons;pharmacologic;Phase;Physical activity;Population;premature;Process;Proteins;Public Health;Rattus;receptor;Reflex action;Research;response;Risk;Role;Sensory;sex;Sex Differences;Skeletal Muscle;Spinal Ganglia;Stroke;Techniques;Testing;Thinness;Western Blotting;Work

PROJECT_TITLE: Mechanisms of Type 1 Diabetes in the Autonomic Control of Circulation During Exercise

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The research funded by this proposal aims to understand how changes in cellular metabolism help cells fight viral infections. Broadly, this metabolic reprograming involves changes in the activity of numerous enzymes in cell, but how this is accomplished remains to be understood. A better understanding of this process may help facilitate the development of improved treatments for viral infections and other diseases.

PI_NAMEs: MARSH, E NEIL (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Anti-viral Agents;Anti-viral Response;Biochemical;Biological;Cell Line;Cell membrane;Cells;Cholesterol;Complex;Development;Disease;DNA-Directed RNA Polymerase;Endoplasmic Reticulum;enzyme mechanism;Enzymes;Eukaryotic Cell;Fatty Acids;fighting;Flavivirus;Funding;HIV/HCV;Human;Immune signaling;improved;Infection prevention;Influenza A virus;Innate Immune Response;Interferons;Mammalian Cell;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Nucleotides;Outcome;oxidation;Pathway interactions;Process;Property;protein protein interaction;Proteins;Regulation;Research;Research Support;response;RNA Viruses;Signal Pathway;Transfection;ubiquitin ligase;United States National Institutes of Health;viperin;Viral;Viral Physiology;Viral Proteins;Virus;Virus Diseases;Virus Inhibitors;Virus Replication

PROJECT_TITLE: Mechanisms of Enzyme Regulation by Viperin in the Cellular Antiviral Response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-H (56)]


NIH_SPENDING_CATS: Prevention

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative Cytokinesis, the physical division of one cell into two daughter cells, is a highly conserved process central to development and tissue maintenance. Cytokinesis is tightly regulated so that it occurs only after chromosome replication and segregation to prevent catastrophic genomic instability and cell death. The goal of the Gould lab is to advance understanding of how the molecules essential for successful cytokinesis are assembled into an actin- and myosin-based macromolecular structure and regulated so that assembly occurs only at the correct time and place in the cell.

PI_NAMEs: GOULD, KATHLEEN L (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Actins;Architecture;Biochemistry;calcineurin phosphatase;casein kinase I;Cell Cycle;Cell Death;Cell division;Cell membrane;Cells;chromosome replication;Chromosome Segregation;CSNK1A1 gene;Cues;Cytokinesis;daughter cell;design;Development;Ensure;Enzymes;event cycle;Family;Fission Yeast;Genetic;Genetic Screening;Genomic Instability;Goals;Homeostasis;Human;human disease;interdisciplinary approach;Knowledge;Learning;Maintenance;Microscopy;Mitotic Checkpoint;model organism;Molecular Structure;Myosin ATPase;Phosphotransferases;physical separation;prevent;Process;Proteins;Proteomics;Regulation;Research;Role;scaffold;Signal Transduction;Time;Tissues;Work;Yeasts

PROJECT_TITLE: Cell Division Signaling

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Antimicrobial Resistance;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: This grant will generate new chemical tools and approaches needed to build a comprehensive understanding of bacterial cell wall synthesis and signal transduction. This work will fill in major gaps in fundamental knowledge, critical for the future development of novel antibiotics and strategies to combat antibiotic-resistant bacterial diseases.

PI_NAMEs: CARLSON, ERIN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Adjuvant;Anabolism;Antibiotic Resistance;Antibiotics;Area;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;beta-Lactams;Biochemistry;Biology;Cell division;cell growth;Cell Survival;Cell Wall;Cells;chemical synthesis;Chemicals;combat;Cytoplasm;Development;Disease;Disparate;Environment;environmental change;environmental stressor;Enzymes;Exposure to;Family;Foundations;Future;Genome;Grant;Internet;Investigation;Knowledge;Label;Lead;Leadership;Libraries;Ligands;Maps;Mass Spectrum Analysis;Methods;Microbiology;morphogens;novel;Organism;Penicillin-Binding Proteins;periplasm;Planets;Protein Family;Protein Kinase;protein-histidine kinase;Proteins;Qualifying;Research;Resistance to infection;response;Role;Signal Transduction;Stimulus;Testing;tool;transmission process;United States National Institutes of Health;Virulence;Vision;Work

PROJECT_TITLE: Chemical Strategies to Map Bacterial Response to Environmental Change

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOCHEMISTRY

PHR: NARRATIVE It has become increasingly clear in recent years that metabolism exerts a profound influence on the behaviors of cells, tissues and organisms. We posit that much of this effect is mediated by direct physical interactions between metabolites and macromolecules, like proteins and RNAs. We have developed and validated a platform technology that enables the discovery of such interactions, and now propose to implement if in a more systematic way to define mechanisms whereby metabolites signal to influence normal and disease physiology.

PI_NAMEs: RUTTER, JARED P (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TITLE: Mechanisms of metabolite signaling


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: STONY BROOK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE The goal of our research program is to develop and validate new sampling, scoring, and chemical searching techniques, for more accurate prediction of molecular recognition at the atomic level, to enable greater understanding of biological systems relevant to public health. We are creating new molecular assembly platforms to facilitate from-scratch construction (de novo design, molecular evolution) of small organic molecules with cheminformatics properties customized to the binding site(s) being targeted. We apply our tools to make testable predictions in collaboration with experimental groups, and we make them widely available to the research community.

PI_NAMEs: RIZZO, ROBERT C. (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Algorithms;Bacterial Drug Resistance;Basic Science;Binding Sites;Biological;biological systems;Ceramidase;Chemicals;cheminformatics;clinically relevant;Collaborations;Communities;Computer Models;Computer software;computerized tools;Data;Databases;Descriptor;design;design verification;Development;Docking;Ebola;empowerment;Epidermal Growth Factor Receptor;ERBB2 gene;experience;experimental group;fatty acid-binding proteins;Geometry;Goals;Growth;HIV;improved;interest;laboratory experiment;Lead;Libraries;Ligands;Malignant Neoplasms;method development;Methodology;Methods;molecular assembly/self assembly;Molecular Computations;Molecular Evolution;molecular recognition;Mycoses;New Agents;Outcome;Pharmaceutical Preparations;Productivity;Program Development;programs;Property;Proteins;Protocols documentation;Public Health;Research;Sampling;Software Design;Specificity;Structure;System;Techniques;Thinking;tool;user-friendly;Validation;Viral;web server;ZIKA

PROJECT_TITLE: Development, Validation, and Application of Structure-based Tools for Computational Molecular Design

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Cancer;Infectious Diseases;Natural Products;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE. Our research program seeks to elucidate the mechanism of action and clinical potential of anticancer and anti- microbial metabolites and synthetic compounds. We pursue advances in chemical synthesis and strategy to gain access to these molecules and modify their structures with precision. Our work will continue to deliver new preclinical candidates for the treatment of cancers and drug-resistant infections.

PI_NAMEs: HERZON, SETH B. (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Alkylation;Anabolism;Anions;anomer;anti-cancer;Antibiotics;antimicrobial;Bacterial Infections;Binding;Biological;cancer therapy;chemical synthesis;Chemistry;chemotherapy;Clinical;Collaborations;Coupling;Crystallography;Data;Development;dimer;DNA;DNA Repair Gene;Drug resistance;Excision;Funding;Glycosides;glycosylation;Goals;Guanine;Hydroxyl Radical;in vivo;Infection;Inhibition of Cancer Cell Growth;insight;Lead;lomaiviticin A;Malignant neoplasm of ovary;Malignant Neoplasms;Methods;MGMT gene;Modernization;Molecular;mouse model;mutant;natural antimicrobial;Natural Products;novel;Peroxides;Platinum;pleuromutilin;Positioning Attribute;pre-clinical;programs;Protons;Reaction;Reagent;Research;resistance mechanism;Ribosomes;secondary metabolite;Structure;Structure-Activity Relationship;Tissues;translational study;Tropolone;tumor;Work

PROJECT_TITLE: Synthetic and translational studies of antitumor and antimicrobial natural products.


ORG_CITY: LUBBOCK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

PHR: Project Narrative Ion-coupled transporters play important roles. We will characterize two Na+-coupled transporters that is involved in health and serves as a prototype for the study of ion-coupled transport mechanisms structurally and functionally. The expected outcome will improve our fundamental knowledge of active transport and impact novel drug development. 1

PI_NAMEs: GUAN, LAN  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Active Biological Transport;Amino Acid Transporter;Amino Acids;Architecture;Binding;Binding Proteins;Biochemical;Biological Assay;biophysical techniques;Cations;Cell Physiology;Cells;Chronic Disease;Communities;Complement;Coupled;Coupling;Cryoelectron Microscopy;Data;Deuterium;Development;Disease;drug development;Drug Kinetics;Epithelium;Health;Hydrogen;improved;inhibitor;insight;Ion Cotransport;Ions;Kinetics;Knowledge;Laboratories;Malignant Neoplasms;Mass Spectrum Analysis;Membrane Proteins;Methods;Molecular;Molecular Conformation;molecular dynamics;nanobodies;novel;novel therapeutic intervention;novel therapeutics;Nutrient;Outcome;particle;Play;prototype;Publishing;reconstitution;Research;Role;scaffold;Structural Biochemistry;structural biology;Structure;Substrate Specificity;sugar;symporter;tool

PROJECT_TITLE: An integrated approach to understanding the molecular mechanisms of cation-coupled transport


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Relevance to Public Health, Project Narrative Through this project we will support and maintain an essential resource for the creation of the IGVF Catalog. The Catalog will incorporate results from IGVF experimental investigation, and computational analyses using a wealth of information on genomic variants impact on function. One of the essential data sources of these analyses is the collected knowledge of the ENCODE Consortium provided via the ENCODE Portal that serves as the primary data warehouse for ENCODE data.

PI_NAMEs: CHERRY, J. MICHAEL (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Archives;Award;Biomedical Research;Catalogs;Cells;Charge;Cloud Computing;Cloud Service;Communities;Complex;Computer Analysis;Computer software;Data;Data Coordinating Center;data management;Data Set;Data Sources;data warehouse;Databases;design;Disease;Educational workshop;Electronic Mail;Elements;Gene Expression;genetic variant;genome annotation;Genomics;Goals;Grain;graph database;Human;Human Genome;Informatics;interest;Internet;Investigation;Knowledge;knowledge graph;knowledgebase;Maintenance;Metadata;Minor;molecular phenotype;online resource;Pathway Analysis;privacy preservation;Process;Public Health;Reagent;Regulation;Regulatory Element;Reporting;repository;Research;Research Personnel;Resources;response;Role;Services;Side;social media;software development;Structure;Students;Technical Expertise;Technology;Tissues;Update;Variant;Work

PROJECT_TITLE: Maintenance of ENCODE Portal, an essential resource for the IGVF Catalog

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Antimicrobial Resistance;Cancer;Colorectal Cancer;Digestive Diseases;Infectious Diseases;Microbiome;Natural Products

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Proposal Narrative This proposal focuses on a.) the development of new synthetic tactics to access exceptionally rare, biologically relevant hetercyclic compounds and b.) the design, synthesis, and use of novel chemical probes to understand broadly deployed, fundamental metabolic pathways that govern polysaccharide metabolism in prominent human gut bacteria. The work will provide new synthetic strategies to enable the discovery of novel biologically active compounds, and new chemical tools to facilitate a broader understanding of foundational metabolic processes of human gut bacteria that is relevant to human health and disease.

PI_NAMEs: WHITEHEAD, DANIEL CHARLES (contact)

PROJECT_TITLE: Chemical synthesis to access rare heterocycles and tool compounds to probe bacterial polysaccharide metabolism


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Given that American Indian (AI) persons experience one of the most extreme smoking inequities, a scalable and culturally-aligned smoking cessation intervention could have a meaningful public health impact in this population. Through engagement with tribes and AI serving clinics and nationally drawn community advisory boards (CABs), our team has conducted multiple preliminary studies to culturally tailor NCI’s Smokefree TXT and QuitGuide smartphone app for AI persons. The present study will culturally-align the final Smokefree resource (Smokefree.gov) and then utilize mixed-methods to evaluate the efficacy of Smokefree for Natives, a suite of culturally-aligned digital cessation resources, among AI persons who smoke.

PI_NAMEs: CARROLL, DANA MOWLS (contact);PICKNER, WYATT

PROGRAM_OFFICER_NAME: PRUTZMAN, YVONNE M

PROJECT_TERMS: 18 year old;Abstinence;Address;age effect;Agreement;American Indian community;American Indian Population;American Indian Tribe;American Indians;Behavior Therapy;Biochemical;Caucasians;Cigarette;Clinic;Clinical Trials;Collaborations;Communities;community advisory board;community engagement;community partners;comparative;Creativeness;Data;demographics;digital;Disparity;effective intervention;efficacy evaluation;efficacy testing;Equity;evidence base;experience;Facebook;General Population;Geographic Locations;Geography;Goals;Grief reaction;healing;Health;Home;improved;Indigenous;Inequity;interest;Intervention Studies;Interview;Malignant Neoplasms;Mediator;Methodology;Methods;Native Americans;natives;Outcome;Participant;Perception;Persons;Pharmacotherapy;Population;programs;Public Health;Random Allocation;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Research;Resources;response;Sampling;satisfaction;sex;smartphone application;Smoke;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking-related cancer;social media;Source;Spirituality;Subgroup;substance use;Technology;Text;Tobacco;Tobacco use;tribal Nation;Tribes;United States Substance Abuse and Mental Health Services Administration;web site;Work

PROJECT_TITLE: Randomized Clinical Trial of a Culturally-Tailored Suite of Smoking Cessation Resources for American Indian Persons

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-P (55)]


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative This research aims to determine the structure, dynamics, and function of membrane proteins involved in bacterial pathogenesis and survival. The understanding of these molecular interactions provides insights into protein-protein molecular recognition, the rational design of novel targeted liposomal therapeutics, and novel antibiotics.

PI_NAMEs: COLUMBUS, LINDA M (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TITLE: Biophysical understanding of pathogen-host membrane protein interactions for drug discovery and delivery


ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative  Synthetic methods that rapidly generate complex organic molecules are critical for the development of selective biological probes and therapeutics. The overarching goal of this project is to explore transition metal redox catalysts for the reductive generation of carbene equivalents from readily available gem-dihalo starting materials. Using this approach, we will develop cycloaddition reactions that form odd-membered rings and vinylidene carbon–carbon coupling reactions that form chiral building blocks.

PI_NAMEs: UYEDA, CHRISTOPHER  (contact)

PROJECT_TITLE: Transition Metal Catalyzed Reductive Carbene Transfer Reactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]