PROJECT_TERMS: Apoptosis;biological adaptation to stress;Biological Assay;cancer cell;Cell Survival;Cytosol;design;Disease;Dislocations;Endoplasmic Reticulum;Environment;HepG2;inhibitor;interest;Luciferases;Malignant Neoplasms;misfolded protein;Process;Proteasome Inhibitor;protein misfolding;Proteins;Rabies;Rabies virus;Recombinants;Reporter;response;Role;screening;small molecule;small molecule inhibitor;therapeutic development;Toxic effect;Triage;Viral;Work

PROJECT_TITLE: Identifying inhibitors of ER retrotranslocation/dislocation


ACTIVITY: ZIA

ADMINISTERING_IC: TR

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

PI_NAMEs: SIMEONOV, ANTON  (contact)

PROJECT_TERMS: analog;Atherosclerosis;Blood Platelets;Cardiovascular system;Carotid Artery Diseases;Chronic Granulomatous Disease;Endothelial Cells;Exhibits;Generations;Genes;Goals;Immune System Diseases;inhibitor;loss of function;Mutation;NADPH Oxidase;Patients;Phagocytes;Reactive Oxygen Species;Research;Site;small molecule inhibitor

PROJECT_TITLE: NADPH-oxidase 2 inhibitors for cardiovascular indications


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

PI_NAMEs: ZAKHAROV, ALEXEY  (contact)

PROJECT_TERMS: analog;Binding Sites;Biological Assay;Cells;Genetic Transcription;Goals;high throughput screening;Human;inhibitor;Malignant Neoplasms;Messenger RNA;miniaturize;novel;Oncogenes;overexpression;Pharmaceutical Chemistry;programs;Proteins;Proteome;Role;screening;small molecule;Testing;Translational Repression;Translations;Treatment Efficacy;tumor progression

PROJECT_TITLE: Identification of Myc translation inhibitors


NIH_SPENDING_CATS: Cancer;Neurodegenerative;Rare Diseases

PI_NAMEs: MARUGAN, JUAN  (contact)

PROJECT_TERMS: Agonist;analog;Automobile Driving;Basic Science;Binding Sites;Biological Assay;Cancer Model;Cells;Coupling;drug candidate;Fabry Disease;Health;Human;Human Genome;improved;Lipids;Measures;Metabolism;Mitochondria;Modeling;mouse model;National Center for Advancing Translational Sciences;novel;paralogous gene;pharmacologic;Phenotype;Production;programs;Rare Diseases;Research;tool;Translations

PROJECT_TITLE: Identification of modulators of TRAP1


NIH_SPENDING_CATS: Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

PROJECT_TERMS: Antibiotic Therapy;Antibiotics;antimicrobial;Awareness;Bacteria;Binding;Biological Assay;biophysical techniques;Borrelia;Borrelia burgdorferi;Chronic;Clinical;Collaborations;counterscreen;Development;Disease;Etiology;experience;follow-up;Goals;Infection;inhibitor;Libraries;Lyme Disease;Measures;Methods;miniaturize;mouse model;novel;Order Spirochaetales;Pathogenicity;Patients;Post Treatment Lyme Disease Syndrome;Prevalence;protein protein interaction;Proteins;Reporting;screening;Series;small molecule inhibitor;Testing;Tick-Borne Diseases

PROJECT_TITLE: Identification of inhibitors of BB323 and BB238 interaction in Borrelia burgdorferi (chronic Lyme disease)


NIH_SPENDING_CATS: Biotechnology;Microbiome;Patient Safety

PI_NAMEs: HALL, MATTHEW  (contact)

PROJECT_TERMS: Bacteria;Beta-glucuronidase;Biochemical;Biological Assay;Cells;Chemicals;Disease;Dose Limiting;Drug toxicity;Enzymes;Exhibits;follow-up;high throughput screening;Homology Modeling;in vitro Assay;inhibitor;Lead;microbiome;miniaturize;National Center for Advancing Translational Sciences;novel;Orthologous Gene;Pharmaceutical Chemistry;Pharmaceutical Preparations;Powder dose form;programs;Series;small molecule;small molecule libraries;Therapeutic;Toxic effect;Validation;virtual screening

PROJECT_TITLE: qHTS to Identify Small Molecule GUS Inhibitors


NIH_SPENDING_CATS: Brain Disorders;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;analog;Arachidonate 15-Lipoxygenase;Biological Assay;Cells;design;Disease;disease model;Goals;improved;In Vitro;in vivo Model;inhibitor;Pharmaceutical Chemistry;protein complex;Proteins;Research;Research Personnel;Role;screening;small molecule;small molecule inhibitor;Structure;Traumatic Brain Injury;Work

PROJECT_TITLE: Improving 15-LOX-2 small molecule inhibitors through medicinal chemistry and structure-guided design


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: XU, XIN  (contact)

PROJECT_TERMS: absorption;Acceleration;Address;Adult;Agonist;Aldehyde oxidase;Animals;Antibodies;antibody detection;antibody test;aqueous;artificial intelligence model;Bile fluid;Binding Proteins;Biodistribution;Biological;Biological Assay;Biological Products;Biophysics;Blood;Caco-2 Cells;Cell Membrane Permeability;Cell Survival;Cells;Chemicals;Child;Clinic;Clinical Trials;Collaborations;cost;Country;COVID-19;CYP2C9 gene;CYP3A4 gene;Cytosol;Data;Data Set;design;Development;Devices;Dose;drug candidate;drug development;drug discovery;Drug Kinetics;drug metabolism;drug-like compound;Duchenne muscular dystrophy;efficacy study;Electrical Resistance;Ensure;Enzymes;Evaluation;Excretory function;Extramural Activities;Failure;falls;first-in-human;Gene Expression;gene therapy;Generations;Goals;good laboratory practice;Grant;GS-441524;Hepatic;Hepatocyte;High Pressure Liquid Chromatography;high throughput screening;Human;Human Cell Line;human study;immunogenicity;in silico;In Vitro;in vivo;Incubated;innovation;International;Intestines;Intramural Research;Investigational New Drug Application;Kinetics;Laboratory Animals;Lead;Libraries;Liquid Chromatography;Liquid substance;Liver Microsomes;Machine Learning;macromolecule;Manuscripts;Mass Spectrum Analysis;Measurement;Measures;Medicine;meetings;Membrane;Metabolic;Metabolism;Metaphyseal chondrodysplasia;method development;Methods;Microsomes;Mission;model development;Modeling;models and simulation;Monitor;Mus;National Center for Advancing Translational Sciences;novel;novel therapeutics;open label;Oral;Oral Administration;Peptides;Performance;Permeability;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;Plasma;Plasma Proteins;Play;pre-clinical;preclinical study;Process;Prodrugs;Property;Protein Engineering;Proteins;Protocols documentation;PTH gene;PubChem;Publications;Publishing;Rattus;Reagent;Recombinants;Regimen;remdesivir;Reproducibility;Research;Research Personnel;Research Project Grants;Resolution;Resources;Role;Safety;safety study;Sampling;Scientist;Small Business Innovation Research Grant;small molecule;Solubility;Structure;subcutaneous;Sulfhydryl Compounds;symposium;System;tandem mass spectrometry;Techniques;Technology;therapeutic candidate;therapeutic development;Tight Junctions;Tissue Extracts;tool;Toxic effect;toxicant;Toxicology;Translational Research;United States National Institutes of Health;Urine;Validation;wasting;web site;Work

PROJECT_TITLE: Pharmacokinetics and Drug Metabolism


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

PROJECT_TERMS: Automobile Driving;Basic Science;bcr-abl Fusion Proteins;Binding;blood-brain barrier crossing;Brain;Brain Neoplasms;Cells;Clinical;Collaborations;drug candidate;Glioblastoma;Health;Human;Human Genome;improved;In Vitro;in vivo;inhibitor;interest;Modality;Myristates;National Center for Advancing Translational Sciences;novel;Oncogenic;pharmacologic;Phosphotransferases;programs;Rare Diseases;Reporting;Research;Resistance;resistance mutation;Testing;Therapeutic;tool;Translations;tumor initiation;Tyrosine Kinase Inhibitor

PROJECT_TITLE: Characterizing inhibitors of tyrosine protein kinase ABL1 (ABL1) in human glioblastoma


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases

PROJECT_TERMS: Anti-Bacterial Agents;Antibiotics;Automobile Driving;bacterial metabolism;Basic Science;Biological Assay;Cells;clinical practice;Complex;cyanine dye 5;Development;drug candidate;Drug Targeting;Elongation Factor;Escherichia coli;Fluorescence Resonance Energy Transfer;Fluorescent Dyes;Formulation;Future;Gram-Negative Bacteria;Guanosine Triphosphate;Health;high throughput screening;Homologous Gene;Human;Human Genome;improved;In Vitro;in vivo;Infectious Skin Diseases;inhibitor;Modeling;Mycobacterium tuberculosis;National Center for Advancing Translational Sciences;natural product derivative;novel;Organism;pathogen;Permeability;pharmacologic;Phenylalanine-Specific tRNA;programs;Protein Biosynthesis;Rare Diseases;Reagent;Reporting;Research;screening;small molecule libraries;Streptomyces;Testing;tool;Transfer RNA Aminoacylation;Translations;Work

PROJECT_TITLE: Identifying novel antibiotics by targeting the EF-Tu complex formation


PROJECT_TERMS: Affect;Anti-Inflammatory Agents;Antiinflammatory Effect;Autoimmune Diseases;Automobile Driving;Basic Science;Biological Assay;Body System;cell immortalization;Cell Line;cell type;Cells;Chromosome Mapping;Clinical;Development;Dose Limiting;drug candidate;Drug Prescriptions;Engineering;Exposure to;Gene Expression Profiling;Generations;Genes;Genomics;Glucocorticoids;Goals;Health;healthy volunteer;high throughput screening;Human;Human Genome;Immune;Immune Targeting;Immunosuppression;improved;In Vitro;in vivo Model;Inflammatory;Measures;mimetics;Molecular;monocyte;nanobodies;National Center for Advancing Translational Sciences;novel drug class;Pathway interactions;Performance;Pharmaceutical Preparations;pharmacologic;Production;programs;Protocols documentation;Rare Diseases;Reporter;Reporting;Reproducibility;Research;response;side effect;small molecule;Testing;tool;transcriptome sequencing;Translations;Work

PROJECT_TITLE: Selective targeting of immune-specific glucocorticoid-sensitive genes


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

PROJECT_TERMS: Amphotericin B;antagonist;anti-fungal agents;Antifungal Therapy;Aspergillus fumigatus;Automobile Driving;Azoles;Basic Science;Biological Assay;Candida albicans;Candida glabrata;clinical efficacy;Cryptococcus neoformans;Death Rate;drug candidate;Fungal Drug Resistance;Health;high throughput screening;Human;Human Genome;improved;Mycoses;National Center for Advancing Translational Sciences;pathogenic fungus;Patients;Pharmaceutical Preparations;pharmacologic;Predisposition;programs;Rare Diseases;Reporting;Research;resistance mechanism;screening;tool;Translations;Work

PROJECT_TITLE: Antifungal Antagonism Screening


NIH_SPENDING_CATS: Brain Disorders

PROJECT_TERMS: addiction;Alcohols;Automobile Driving;Basic Science;Binding Sites;Biological Assay;Databases;drug candidate;Early identification;Electrophysiology (science);Fluorescence;GIRK2 subunit, G protein-coupled inwardly-rectifying potassium channel;Health;Homology Modeling;Human;Human Genome;improved;in silico;Ion Channel;Molecular Bank;molecular modeling;N-terminal;National Center for Advancing Translational Sciences;Pharmaceutical Preparations;pharmacologic;programs;Rare Diseases;Reporting;Research;screening;Screening Result;tool;Translations;Work

PROJECT_TITLE: Identification of GIRK2 channel modulators


PI_NAMEs: RAI BANTUKALLU, GANESHA  (contact)

PROJECT_TERMS: aldehyde dehydrogenases;Aldehydes;ALDH1A2 gene;Betaine;Biochemical;Biological Assay;Cells;Cellular Assay;Chemicals;Data Set;Development;Disease;Environmental Pollutants;Enzymes;Family;follow-up;Future;gamma-Aminobutyric Acid;Goals;high throughput screening;in silico;Inflammation;inhibitor;Libraries;Malignant Neoplasms;Molecular Probes;National Center for Advancing Translational Sciences;nutrient metabolism;Obesity;Pharmaceutical Preparations;pharmacologic;Process;Protein Isoforms;Role;screening;Signal Transduction;Specificity;Therapeutic;Tretinoin

PROJECT_TITLE: Identification of isoform-selective ALDH inhibitors


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Cancer;Infectious Diseases;Psoriasis;Regenerative Medicine;Skin Cancer;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: FERRER, MARC  (contact)

PROJECT_TERMS: 3-Dimensional;Anti-viral Agents;Atopic Dermatitis;biofabrication;Biological Assay;bioprinting;cancer cell;Cancer Model;Cells;Chemosensitization;chemotherapeutic agent;clinical predictors;cohort;Collaborations;Collection;cytokine;Dermis;Disease;disease model;disease phenotype;disease-in-a-dish;drug discovery;Drug Modelings;Drug Screening;Endothelial Cells;Epidermis;Fibroblasts;Fibrosis;Fluorescence Microscopy;Goals;high throughput screening;Human;Immune;in vitro Assay;induced pluripotent stem cell;Infection;keratinocyte;Label;Libraries;Macrophage;Malignant Neoplasms;Measures;Melanoma;Mesenchymal Stem Cells;microbiome;Modeling;Morphology;National Center for Advancing Translational Sciences;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Oncology;Outcome;Patients;Permeability;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Protocols documentation;Psoriasis;Reporter;response;Scleroderma;screening;Simplexvirus;Skin;Skin Cancer;skin disorder;skin fibrosis;skin squamous cell carcinoma;Skin Tissue;Stress;stressor;Techniques;Testing;Th2 Cells;Therapeutic Effect;Thick;Tissue Engineering;Tissue Model;Tissues;Universities;Vascularization;Virus;Virus Diseases;Virus Replication;Washington

PROJECT_TITLE: 3D Bioprinted skin models for drug screening


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Lung;Lung Cancer;Orphan Drug;Prevention;Rare Diseases;Urologic Diseases

PROJECT_TERMS: 3-Dimensional;Aftercare;airway epithelium;angiogenesis;anti-cancer therapeutic;Antitumor Drug Screening Assays;Biological Assay;biomarker discovery;bioprinting;Bladder;Breast;cancer cell;Cancer Cell Growth;Cancer Detection;Cancer Model;Cell Line;Cell model;Cells;cellular imaging;Collection;Development;drug development;drug discovery;Drug Modelings;Drug Screening;efficacy testing;Endothelial Cells;Epithelial Cells;Epithelium;Fibroblasts;Fluorescence;Fluorescence Microscopy;Functional disorder;Goals;Growth;Human;Image Analysis;Immune;Immunodeficient Mouse;In Vitro;Label;lentivirally transduced;Lung;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;Mesothelial Cell;Mesothelioma;Modeling;Monitor;monolayer;Morphology;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Non-Small-Cell Lung Carcinoma;Oncology;Pericytes;pharmacologic;Physiological;Physiology;preclinical efficacy;Preclinical Testing;predictive test;prevent;Proliferating;Proteins;Protocols documentation;Recurrent disease;response;screening;Structure of parenchyma of lung;Surface;Therapeutic;Therapeutic Intervention;Tissue Model;Tissues;transcriptomics;tumor;tumor growth;Vascularization;vasculogenesis;Xenograft procedure

PROJECT_TITLE: 3D Bioprinted lung cancer models for drug screening


NIH_SPENDING_CATS: Aging;Bioengineering;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PROJECT_TERMS: 3-Dimensional;angiogenesis;bevacizumab;bioprinting;Blood-Retinal Barrier;Bruch's basal membrane structure;Choroid;Choroidal Neovascularization;clinically relevant;Disease;Drug Modelings;Drug Screening;Engineering;Extracellular Matrix;Exudative age-related macular degeneration;Goals;human induced pluripotent stem cells;hypoxia inducible factor 1;improved;in vitro Model;Macrophage;Modeling;new therapeutic target;Pathologic Neovascularization;Phenotype;Photoreceptors;Prevention;Recovery;Recurrence;Retina;Retinal Diseases;senescence;Structure of retinal pigment epithelium;Techniques;Therapeutic;therapeutic development;therapeutic target;Tissue Model;Tissues;Vascular Endothelium;Vascularization;Virus Diseases;Vision;ZIKV infection

PROJECT_TITLE: 3D Bioprinted retina models for drug screening


PROJECT_TITLE: Profiling of methyltransferases


NIH_SPENDING_CATS: Rare Diseases

PROJECT_TERMS: Adenoviruses;Automobile Driving;Basic Science;Binding;Biological Assay;biophysical techniques;candidate identification;design;drug candidate;Health;Human;Human Genome;improved;Lead;National Center for Advancing Translational Sciences;novel;pharmacologic;programs;Rare Diseases;Reagent;Reporting;Research;small molecule;Testing;tool;Translations;Viral Physiology;virtual screening;Work

PROJECT_TITLE: Modulators of RPS14 with broad antiviral activity


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease;Rare Diseases

PI_NAMEs: HENDERSON, MARK  (contact)

PROJECT_TERMS: Automobile Driving;Autosomal Dominant Polycystic Kidney;Basic Science;Cations;Cell membrane;disease-causing mutation;drug candidate;Health;high throughput screening;Human;Human Genome;improved;Integral Membrane Protein;molecular modeling;Mutation;National Center for Advancing Translational Sciences;novel;pharmacologic;polycystic kidney disease 1 protein;programs;Rare Diseases;Research;Testing;tool;Translations;virtual screening

PROJECT_TITLE: High-throughput screening to identify modulators of PKD2 function


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Neurosciences;Orphan Drug;Rare Diseases

PROJECT_TERMS: Automobile Driving;Basic Science;Brain;brain cell;Breast;Cells;combinatorial;drug candidate;Drug Kinetics;efficacy study;Formulation;Health;high throughput screening;Human;Human Genome;improved;inhibitor;Metastatic malignant neoplasm to brain;National Center for Advancing Translational Sciences;novel;pharmacologic;programs;Rare Diseases;Research;screening;small molecule;tool;Toxic effect;Translations

PROJECT_TITLE: High-throughput screening to identify inhibitors of breast-to-brain metastasis


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PROJECT_TERMS: Binding;Biological Assay;Cell Membrane Permeability;Complex;data acquisition;Development;Devices;Dose;Environment;experimental study;Heating;high throughput screening;improved;Kinetics;lead optimization;luminescence;melting;Methods;nanoluciferase;Proteins;prototype;rapid testing;response;screening;small molecule;Technology;Time;Variant

PROJECT_TITLE: Development of high-throughput CETSA target engagement assays


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Estrogen;Prostate Cancer;Urologic Diseases;Women's Health Research

PROJECT_TERMS: advanced disease;Androgens;Binding;Biochemical;Biological Assay;breast cancer progression;Cellular Assay;Chemicals;Clinical;Collection;Estrogens;Excision;Goals;hormone therapy;Hormones;inhibitor;Ligands;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;multicatalytic endopeptidase complex;National Center for Advancing Translational Sciences;novel strategies;Nuclear Hormone Receptors;Nuclear Receptors;Pharmaceutical Chemistry;Polyubiquitin;prevent;Production;receptor;receptor function;Reporting;Research;RNA Interference;small molecule inhibitor;System;Therapeutic Intervention;Ubiquitin;ubiquitin isopeptidase

PROJECT_TITLE: Identification of small molecule inhibitors of DUB3


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

PROJECT_TERMS: Antibiotic Therapy;Antibiotics;antimicrobial;Area;assay development;Awareness;Bacteria;Biological Assay;Borrelia;Borrelia burgdorferi;Caseins;Cells;Characteristics;Chronic;Development;Disease;Enzymes;Etiology;experience;extracellular;Fluorescence Resonance Energy Transfer;fluorophore;Genetic Transcription;Growth;Helicobacter pylori;High temperature of physical object;high throughput screening;Homologous Gene;Immune response;Impairment;inhibitor;Label;Literature;Lyme Disease;Molecular Chaperones;Order Spirochaetales;Pathogenesis;Pathogenicity;Patients;Peptides;periplasm;Post Treatment Lyme Disease Syndrome;Prevalence;Protein Family;Proteins;Quality Control;Recombinants;redshift;Reporting;screening;Series;Serine Protease;small molecule;small molecule inhibitor;Specificity;Surface;Testing;Therapeutic Effect;Tick-Borne Diseases;Tissues;tool;Validation;virtual screening;Virulence

PROJECT_TITLE: Screening for small molecule inhibitors of B. burgdorferi HtrA


NIH_SPENDING_CATS: Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

PROJECT_TERMS: Antibiotics;Automobile Driving;Basic Science;Biological Assay;Borrelia;Borrelia burgdorferi;cytotoxicity;Diagnosis;Doxycycline;drug candidate;Focal Infection;Health;Human;Human Genome;improved;interest;Luciferases;Lyme Disease;microbial;Miniaturization;National Center for Advancing Translational Sciences;Pathway interactions;Pharmaceutical Preparations;pharmacologic;programs;Rare Diseases;Recombinants;Reporting;Research;Ribosomes;screening;small molecule libraries;standard care;Structure;Tick-Borne Diseases;tool;Translations;Treatment Protocols;United States;Work

PROJECT_TITLE: Screening for B. burgdorferi borreliacidal/borreliastatic compounds


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Liver Disease;Lung;Neurosciences;Pneumonia;Pneumonia and Influenza

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Address;Air;airway epithelium;Alveolar;Alveolar Cell;Anti-viral Agents;Anti-viral Therapy;antiviral drug development;Area;atypical pneumonia;betacoronavirus;biofabrication;bioprinting;Brain;Cells;Clinical;clinical efficacy;Communities;Community Developments;Coronavirus;COVID-19;COVID-19 patient;COVID-19 pneumonia;Disease;drug development;drug repurposing;Epithelial Cells;Epithelium;Event;Hepatocyte;Human;Immune;in vitro Assay;Infection;influenzavirus;Intestines;Laboratories;Liquid substance;Liver;Lung;Microfluidics;Modeling;National Center for Advancing Translational Sciences;neural;Neurons;novel;pandemic disease;parainfluenza virus;Pathology;Perfusion;Permeability;Pharmaceutical Preparations;Physiological;Positioning Attribute;programs;Protocols documentation;Public Health;Research Activity;research and development;Research Support;respiratory;respiratory virus;response;SARS-CoV-2 infection;Societies;spheroids;Structure of parenchyma of lung;System;Testing;Therapeutic Intervention;thrombotic;Tissue Model;Tissues;Tracheobronchial;Translational Research;United States National Institutes of Health;Vaccines;Variant;Vascularization;Viral;Viral Physiology;Virus;Virus Diseases

PROJECT_TITLE: COVID-19: 3D Bioprinted Tissue Models for Respiratory Viruses


NIH_SPENDING_CATS: Breast Cancer;Cancer;Radiation Oncology;Women's Health Research

PROJECT_TERMS: analog;anti-cancer therapeutic;cancer cell;cancer type;Cell Death;Cell Line;Chemistry;chemotherapy;Coupling;Cytoprotection;Diversity Library;Glutathione Disulfide;glutathione peroxidase;Human;Hydrogen Peroxide;inhibitor;Libraries;Methods;National Center for Advancing Translational Sciences;Non-Small-Cell Lung Carcinoma;novel;Oxidative Stress;Pathway interactions;Powder dose form;Radiation therapy;Reactive Oxygen Species;Recombinants;Role;screening;Selenocysteine;selenoenzyme;small molecule;small molecule inhibitor;Testing;therapy resistant;triple-negative invasive breast carcinoma

PROJECT_TITLE: Screening for novel inhibitors of Glutathione Peroxidase 1 and 4


PROJECT_TERMS: 5'-AMP-activated protein kinase;Adenosine Monophosphate;Autophagocytosis;Biological Assay;Cells;Cholesterol;Data;Disease;efficacy study;Homeostasis;improved;in vivo;Lysosomal Storage Diseases;Mass Spectrum Analysis;Measures;Metabolism;methyl-beta-cyclodextrin;Modeling;National Center for Advancing Translational Sciences;novel;Pathway interactions;Pharmaceutical Chemistry;Protein Kinase;response;Scientist;small molecule;Stress;Testing;Work

PROJECT_TITLE: AMPK synthetic activators


PI_NAMEs: INGLESE, JAMES  (contact)

PROJECT_TERMS: Alleles;alpha synuclein;American;Anti-Infective Agents;Area;autosome;behavioral phenotyping;Biological Assay;Biological Models;Caenorhabditis;Caenorhabditis elegans;Cell Culture Techniques;Cell Line;Cell Membrane Permeability;cell type;Characteristics;Chemical Agents;Chemical Exposure;Chemicals;Collaborations;Cyclic Peptides;Cytometry;Data;design;Development;Disease;disease phenotype;DNA Sequence Alteration;dopaminergic neuron;Drug Screening;drug-like compound;Engineering;Enhancers;Exhibits;experimental study;Fluorescence;follow-up;Foundations;Funding;Future;gene conservation;gene function;Gene Mutation;Genes;Genetic;Genetic Transcription;genome editing;Genotype;Goals;Health;high throughput screening;Homologous Gene;Human;human disease;Human Pathology;Image;in vivo;Infectious Agent;inhibitor;instrumentation;interest;Investigational Therapies;Knock-out;Label;Laboratories;Laser Scanning Cytometry;Lasers;Lead;Libraries;Life;Link;LRRK2 gene;Measures;Medical center;meetings;membrane activity;Methods;Mitochondria;model organism;Monitor;Motility;mutant;Mutation;National Institute of Neurological Disorders and Stroke;Nematoda;Nerve Degeneration;neuron loss;neuronal survival;Neurons;novel;novel therapeutic intervention;Organism;Parkin;Parkinson Disease;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;Phosphoglycerate Mutase;Process;Proteins;Proteomics;Reporter;screening;small molecule libraries;Societies;Sorting;System;Testing;Therapeutic;Therapeutic Agents;Time;Tissues;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: C. elegans as a model organism for human disease through the application of phenologs


PROJECT_TERMS: Automobile Driving;Basic Science;Collaborations;Disease;drug candidate;efficacy study;Evaluation;Goals;Health;Human;Human Genome;improved;inhibitor;Modeling;mouse model;mutant;National Center for Advancing Translational Sciences;Nerve Degeneration;Parkinson Disease;pharmacologic;Phosphotransferases;programs;Rare Diseases;Research;Role;Testing;tool;Translations

PROJECT_TITLE: Evaluation of cAbl allosteric inhibitors in Gaucher-Parkinson


PROJECT_TERMS: autoinflammatory diseases;Biochemical;Biological Assay;Blindness;Cells;Disease;Fever;Goals;Gout;Headache;Helicobacter pylori;high throughput screening;Immune;Inflammation;Inflammatory Bowel Diseases;Inherited;Inhibition of NF-KB activation;inhibitor;Lead;Link;Malignant Neoplasms;Monitor;Mutation;Periodicals;Phosphorylation;Phosphotransferases;Recombinants;reduce symptoms;Reporter;Reporter Genes;Reporting;Role;sensor;Signal Transduction;small molecule;small molecule inhibitor;small molecule libraries

PROJECT_TITLE: Identification of ALPK1 inhibitors


NIH_SPENDING_CATS: Infectious Diseases

PROJECT_TERMS: antagonist;Anti-Retroviral Agents;Biological Assay;brain tissue;Cells;Cerebrospinal Fluid;Combined Modality Therapy;Detection;Diversity Library;Hela Cells;HIV;lead optimization;Miniaturization;National Center for Advancing Translational Sciences;Peripheral Blood Mononuclear Cell;Pharmaceutical Chemistry;Proteins;screening;success;T-Lymphocyte;tat Protein;Transcript;Validation;Viral Load result;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: HTS screening and identification of HIV-Tat antagonists


PROJECT_TERMS: Binding;Biochemical;Biological Assay;Biological Process;Chemicals;Clinic;Collection;Complex;Development;Docking;Enzyme Inhibitor Drugs;enzyme substrate;Epigenetic Process;Histamine;Individual;inhibitor;methyl group;Methyltransferase;Norepinephrine;novel;Pharmaceutical Chemistry;Play;protein structure;Rare Diseases;S-Adenosylhomocysteine;S-Adenosylmethionine;Signal Pathway;simulation;small molecule;small molecule inhibitor;small molecule libraries;Structure;therapeutic candidate;virtual;Work

PROJECT_TITLE: Identification and development of a small molecule probe for GNMT


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: Address;Antibiotic Resistance;Bacterial Drug Resistance;Bacterial Infections;Biological Assay;Clinical;Combined Modality Therapy;Drug Combinations;Drug Kinetics;Drug resistance;Fiber;Infection;Kinetics;Liquid substance;Measures;miniaturize;Modeling;National Center for Advancing Translational Sciences;Pharmaceutical Preparations;Public Health;response;screening;System

PROJECT_TITLE: Assay optimization and screening for measuring the kinetics of antibacterial resistance emergence


PROJECT_TERMS: Address;Anti-Bacterial Agents;Antibiotics;Bacterial Infections;Bacteriophages;Biological Assay;Cells;density;Drug Combinations;Emerging infection;Evaluation;Measurement;Mediating;Multi-Drug Resistance;novel;Optics;Pharmaceutical Preparations;preclinical development;Pseudomonas aeruginosa;Risk;screening;Testing;Work

PROJECT_TITLE: Challenges in Detecting Synergistic Activity of Phage-Mediated Bacterial Killing with Antibiotics in High-Throughput Format


NIH_SPENDING_CATS: Infectious Diseases;Orphan Drug;Rare Diseases

PROJECT_TERMS: Automobile Driving;Basic Science;Biological Assay;Cells;Cessation of life;drug candidate;Health;Human;Human Genome;improved;Lipoxygenase;National Center for Advancing Translational Sciences;new therapeutic target;pathogenic bacteria;pharmacologic;Polyunsaturated Fatty Acids;programs;Pseudomonas aeruginosa;Rare Diseases;Research;screening;small molecule inhibitor;Theft;tool;Translations;Work

PROJECT_TITLE: Identification of small molecule inhibitors of Pseudomonas aeruginosa lipoxygease (pLOXA)-induced ferroptosis


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PROJECT_TERMS: Biological Assay;Biology;cancer cell;Cells;Chemicals;Chromatin;Collaborations;Collection;cost effective;Development;Dose;Enzymes;Epigenetic Process;Ewings sarcoma;Goals;high throughput screening;Investigational Therapies;Measures;National Center for Advancing Translational Sciences;Pattern;Research;response;screening;small molecule;Testing

PROJECT_TITLE: Development of a HT-ATACseq assay to identify epigenetic regulators of Ewing Sarcoma cancer cells (Chemical Biology Consortium/NCI Experimental Therapeutics Collaboration)


PROJECT_TERMS: cancer cell;Cell model;Cells;Chemicals;chemotherapy;Clinical;Collection;cytotoxic;drug sensitivity;Follow-Up Studies;high throughput screening;Invaded;Libraries;Muscle;Neoplasm Metastasis;novel;Oncology;Organ;Phase;prostate cancer cell;prostate cancer cell line;Resistance;small molecule;Smooth Muscle;taxane;Testing;Toxic effect

PROJECT_TITLE: Identifying small molecules with selective toxicity towards muscle invasive prostate cancer cells


NIH_SPENDING_CATS: Autism;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health

PROJECT_TERMS: autism spectrum disorder;Automobile Driving;Basic Science;Cell surface;drug candidate;Health;high throughput screening;Human;Human Genome;improved;Investigation;molecular modeling;National Center for Advancing Translational Sciences;novel;pharmacologic;programs;Proteins;Rare Diseases;Reporting;Research;small molecule;Testing;tool;trafficking;Translations;virtual screening;Work

PROJECT_TITLE: Identification of small molecules that improve trafficking of NLGN4X/Y for autism


NIH_SPENDING_CATS: Biotechnology

PROJECT_TERMS: Affinity;Automobile Driving;Basic Science;cytokine;Disease;drug candidate;ERCC3 gene;Health;high throughput screening;Human;Human Genome;improved;Inflammatory;interest;Methods;National Center for Advancing Translational Sciences;Nuclear Protein;pharmacologic;Phenocopy;Production;programs;Proteins;Proteomics;Rare Diseases;Research;screening;small molecule;Spironolactone;tool;Translations

PROJECT_TITLE: Identification of small molecule degraders of XPB for inflammatory diseases


PROJECT_TERMS: Automobile Driving;Basic Science;Behavior;Biotin;Biotinylation;Dasatinib;drug candidate;Extramural Activities;Health;Human;Human Genome;improved;Label;Ligase;Mass Spectrum Analysis;Methods;Methotrexate;Molecular;National Center for Advancing Translational Sciences;pharmacologic;programs;Proteins;Rare Diseases;Research;small molecule;System;tool;Translations

PROJECT_TITLE: Characterizing molecular interactomes using TurboID


PROJECT_TERMS: Antibodies;Automobile Driving;Basic Science;Blood - brain barrier anatomy;Cerebral endothelium;Chemistry;drug candidate;Encapsulated;exosome;Fc domain;Health;Human;Human Genome;improved;Ligands;Methods;National Center for Advancing Translational Sciences;novel strategies;pharmacologic;Phospholipids;Polysaccharides;programs;Rare Diseases;Research;System;tool;transcytosis;Translations;Vesicle

PROJECT_TITLE: New approaches for facilitating transcytosis of biologically active molecules


PROJECT_TERMS: Adopted;Biological Assay;cancer type;Cell Physiology;Cells;Collection;Complex;Development;Disease;drug repurposing;Drug Screening;Family member;Goals;high throughput screening;Libraries;Mediating;miniaturize;Monitor;multicatalytic endopeptidase complex;nanoluciferase;National Center for Advancing Translational Sciences;Play;Protein Family;Proteins;Publications;Reporter;Reporting;Role;screening;Signal Transduction;small molecule;Triage;ubiquitin ligase;ubiquitin-protein ligase;Validation

PROJECT_TITLE: Screening for small molecule modulators of SCFbTrCP ubiquitin ligase complex


NIH_SPENDING_CATS: Breast Cancer;Cancer;Orphan Drug;Rare Diseases;Women's Health Research

PROJECT_TERMS: Adopted;Automobile Driving;Basic Science;Biological Assay;Breast Cancer cell line;Cancer Cell Growth;Cell Differentiation process;Cells;Collection;demethylation;Development;drug candidate;drug repurposing;Drug resistance;Drug Screening;Genes;Goals;Health;histone demethylase;Histone H3;Human;Human Genome;improved;in vivo;KDM5B gene;Libraries;Lysine;Malignant Neoplasms;miniaturize;Monitor;National Center for Advancing Translational Sciences;Neoplasm Metastasis;novel;overexpression;pharmacologic;programs;Proteins;Rare Diseases;Reporter;Reporting;Research;screening;small molecule;small molecule inhibitor;Specificity;tool;Translations;tumor growth;Validation;Western Blotting;Work

PROJECT_TITLE: Screening for small molecule degraders of KDM5A & B


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Automobile Driving;Basic Science;Biological Assay;Cancer Control;cell motility;Cell Physiology;Cells;Cytoplasm;design;Development;Disease;drug candidate;Drug Targeting;Enzymes;Family;Health;Human;Human Genome;improved;In Vitro;inhibitor;Inositol;Inositol Phosphates;insight;lead optimization;Lipids;Malignant Neoplasms;member;Miniaturization;National Center for Advancing Translational Sciences;novel drug class;Pharmaceutical Chemistry;pharmacologic;pharmacophore;Pharmacotherapy;Phosphorylation;Phosphotransferases;Play;Positioning Attribute;programs;Protein Kinase;Proteins;Publications;Rare Diseases;Recombinants;Research;Role;screening;Signal Transduction;small molecule inhibitor;Structure;tool;Translations;tumor growth;tumor metabolism;Validation

PROJECT_TITLE: In vitro screen for inhibitors of the inositol kinases ITPK1 and PPIP5K


NIH_SPENDING_CATS: Aging;Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Neurodegenerative;Neurosciences;Rare Diseases

PROJECT_TERMS: Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Autophagocytosis;Biological Assay;Cells;Cluster Analysis;Disease;Drug Screening;Golgi Apparatus;Neurodegenerative Disorders;Parkinson Disease;Pathway interactions;Property;protein aggregation;screening;small molecule;Spastic Paraplegia;Syndrome

PROJECT_TITLE: Screening for drugs that mobilize ATG9A from the Golgi as a potential therapy for SPG type 47, 50, 51 and 52 diseases


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Hematology;Liver Disease;Rare Diseases

PROJECT_TERMS: Affect;Bilirubin;Biliverdin reductase;Biliverdine;Binding;Biochemical;Biological Assay;Biophysics;Catabolism;Characteristics;Crigler-Najjar Syndrome;Development;DNA;Heme;high throughput screening;Hyperbilirubinemia;in vivo;inhibitor;Libraries;Neuronal Dysfunction;Newborn Infant;novel;Pharmaceutical Preparations;Production;Proteins;Reporting;screening;Serum;Services;virtual screening

PROJECT_TITLE: Development of inhibitors of biliverdin reductase for toxic hyperbilirubinemia


NIH_SPENDING_CATS: Hematology;Orphan Drug;Rare Diseases;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Binding;Biological Assay;Biophysics;Bone Marrow Transplantation;Development;Disease;Fetal Hemoglobin;Future;high throughput screening;inhibitor;Laboratories;Length;Methods;new therapeutic target;Phosphotransferases;Production;Proteins;Protocols documentation;Reporting;Sickle Cell Anemia;Treatment Cost;Work

PROJECT_TITLE: Development of inhibitors of RIOK3 for sickle cell anemia


PROJECT_TERMS: Affect;anti-cancer;Automobile Driving;Basic Science;Binding;Biological Assay;Cells;Complex;Development;drug candidate;Genes;Goals;Health;high throughput screening;Human;Human Genome;Immune;Immune response;Immunity;improved;Inflammatory Response;Interferon alpha;Interferon Type I;Interferons;ISG15 gene;JAK1 gene;Knock-out;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant Neoplasms;Messenger RNA;National Center for Advancing Translational Sciences;Oncogenic;pharmacologic;programs;Proteins;Rare Diseases;receptor;Reporting;Research;Role;screening;Signal Transduction;small molecule inhibitor;small molecule libraries;Specificity;T cell differentiation;Testing;tool;Translations;tumor;tumor growth;tumor microenvironment;ubiquitin-specific protease

PROJECT_TITLE: Identification of small molecule inhibitors of USP18


PI_NAMEs: PATNAIK, SAMARJIT  (contact)

PROJECT_TERMS: Binding;Biological Availability;Biological Process;Clinic;Collection;Crystallization;Development;Drug Design;Histamine;improved;inhibitor;methyl group;Methyltransferase;Norepinephrine;Oral;Pharmaceutical Chemistry;Pharmaceutical Preparations;Play;Property;Rare Diseases;Reporting;Roentgen Rays;S-Adenosylhomocysteine;S-Adenosylmethionine;Series;Signal Pathway;small molecule;Structure;therapeutic candidate;Transferase;Work

PROJECT_TITLE: Identification and development of a small molecule probe for HNMT


NIH_SPENDING_CATS: Biotechnology;Cancer;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: SHEN, MIN  (contact)

PROJECT_TERMS: anti-cancer;Biological Assay;Bortezomib;Cell Line;cellular targeting;Collaborations;Collection;cytotoxic;cytotoxicity;drug discovery;Ewings sarcoma;FDA approved;Follow-Up Studies;high throughput screening;Jurkat Cells;lactacystin;Libraries;Malignant Neoplasms;multicatalytic endopeptidase complex;National Center for Advancing Translational Sciences;new therapeutic target;Pharmaceutical Preparations;screening;small molecule;small molecule libraries;Source;Technology;Testing;Universities;Work

PROJECT_TITLE: Cytotoxicity profiling of Genesis library in A673 and Jurkat cells


NIH_SPENDING_CATS: Biotechnology;Rare Diseases

PROJECT_TERMS: Adaptor Signaling Protein;Automobile Driving;Autophagocytosis;Autophagosome;Basic Science;Binding;Binding Sites;Biological Assay;Cells;Chimera organism;Complement;design;drug candidate;Fluorescence Polarization;Health;high throughput screening;Homeostasis;Human;Human Genome;improved;interest;Lysosomes;National Center for Advancing Translational Sciences;novel;Pathway interactions;pharmacologic;programs;Protac;Rare Diseases;receptor;Recycling;Reporter;Reporting;Research;small molecule;Stress;Testing;tool;Translations;virtual screening

PROJECT_TITLE: Identifying LC3 binders to develop lysosome-targeting chimeras


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

PROJECT_TERMS: 3-Dimensional;amnion;Anti-Inflammatory Agents;Arum;Award;Biological Assay;bioprinting;Cell Culture Techniques;cell growth;Cell Survival;Cells;Collaborations;cytokine;Decidual Cell;Disease;Drug Screening;Ensure;Epithelial Cells;Exposure to;fetal;fetus cell;Goals;Grant;healthy pregnancy;Inflammation;Inflammatory;Lipopolysaccharides;Maternal-Fetal Exchange;Metabolic;Microfluidics;Modeling;National Center for Advancing Translational Sciences;pharmacologic;Premature Birth;prevent;Side;Testing;Tissue Model;Tissues

PROJECT_TITLE: 3D Bioprinting of feto-maternal barrier tissue models


NIH_SPENDING_CATS: Bioengineering;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Prevention

PROJECT_TERMS: 3-Dimensional;Actins;antifibrotic treatment;Award;BAY 54-9085;Biological Assay;bioprinting;Cell Proliferation;Cell Survival;Cells;Cirrhosis;Clinic;Collaborations;Data;Disease;disease model;Disease Progression;drug candidate;Drug Controls;drug discovery;drug induced liver injury;Drug Screening;Endothelial Cells;Engineering;Environmental Risk Factor;Fatty Acids;Fatty Liver;Fibrosis;Funding;Generations;Genetic;Glucose;Goals;hepatic acinus structure;Hepatocyte;high-throughput drug screening;Human;Immunofluorescence Immunologic;in silico;Inflammatory;Kupffer Cells;Lipids;Liver;Liver diseases;Liver Fibrosis;Measures;Medical;Modeling;Molecular;Monitor;National Center for Advancing Translational Sciences;National Institute of Environmental Health Sciences;non-alcoholic fatty liver;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Pharmaceutical Preparations;pharmacologic;Phenotype;predictive modeling;prevent;Primary carcinoma of the liver cells;Procollagen;progression marker;Reactive Oxygen Species;response;screening;Severity of illness;Signal Transduction;Smooth Muscle;spheroids;stellate cell;Testing;Therapeutic;Tissue Model;Toxic effect;toxicant;Toxicology;United States National Institutes of Health;Universities;Vascularization

PROJECT_TITLE: 3D bioprinting of liver tissue models


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Myasthenia Gravis;Neurosciences;Pediatric;Rare Diseases;Regenerative Medicine

PROJECT_TERMS: 3-Dimensional;Acetylcholine;bioink;Biological Assay;bioprinting;Cells;Chemical Stimulation;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Congenital Myasthenic Syndromes;Contracts;Development;Disease;Drug Screening;Elasticity;Electric Stimulation;Engineering;Foundations;gene therapy;Goals;In Vitro;Individual;induced pluripotent stem cell;instrument;Laboratories;magnetic field;manufacturing scale-up;Measures;mechanical properties;Modeling;Motor Neurons;Muscle;Muscle Contraction;muscle engineering;Muscle Fibers;mutant;Myoblasts;Myopathy;National Center for Advancing Translational Sciences;National Institute of Neurological Disorders and Stroke;Neuromuscular Diseases;Neuromuscular Junction;Neurons;Output;Patients;Process;programs;Reader;response;Robot;Skeletal Muscle;Testing;Therapeutic;therapeutic development;Time;tissue culture;Tissue Engineering;Tissue Model;Virus;ward

PROJECT_TITLE: 3D bioprinting of skeletal muscle and neuromuscular junction tissue models


PROJECT_TERMS: Acids;Amino Acids;analog;Antineoplastic Agents;Applications Grants;ATP-Binding Cassette Transporters;Autoimmune;Autoimmune Diseases;Binding;Biochemical;Biochemistry;Biological Assay;Cancer cell line;Carbon;Chemicals;Clinical;cofactor;Collaborations;Complex;design;Development;Dihydrofolate Reductase;Dihydrofolate Reductase Inhibitor;Disease;DNA biosynthesis;drug discovery;Enzymes;Evaluation;Extramural Activities;Folic Acid;Folic Acid Antagonists;gamma-Glutamyl Hydrolase;high throughput screening;Hydrolysis;improved;insight;Intracellular Transport;Laboratories;member;Metabolism;Methotrexate;methotrexate analog;Mutate;Names;National Center for Advancing Translational Sciences;novel;Nucleic Acids;nucleobase;overexpression;Pathway interactions;Pharmacology;Phenotype;polyglutamates;Prodrugs;programs;Protac;protein expression;Proteins;prototype;Purines;Reaction;resistance mechanism;Rheumatoid Arthritis;Scientist;Series;side effect;Specificity;Technology;Tetrahydrofolates;Therapeutic;therapy resistant;thymidylate;Translations;Work

PROJECT_TITLE: Anti-folate chemotype protein degraders


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: THOMAS, CRAIG  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;antagonist;anti-depressive agents;cancer cell;Cancer Control;cellular targeting;Collaborations;Communities;Development;Drug Kinetics;Dysmyelopoietic Syndromes;Enzymes;FLT3 gene;high throughput screening;inhibitor;Ions;IRAK4 gene;Ketamine;Lead;Metabolic;Methods;Molecular Conformation;Multiple Partners;novel;Pathway interactions;Pharmaceutical Chemistry;pharmacologic;Phenotype;Protein Isoforms;Pyruvate Kinase;receptor;Reporting;Research;research clinical testing;scaffold;side effect;small molecule;tool

PROJECT_TITLE: Bioactive small molecule development


PROJECT_TERMS: 3-Dimensional;Architecture;Biopsy;Cell model;Cells;comparative;Complex;Data;Disease;disease model;drug discovery;drug repurposing;Evaluation;experimental study;facsimile;Genomics;Heterogeneity;Human;innovation;insight;Manuscripts;metabolomics;Methodology;Methods;model design;Modeling;Molecular;Molecular and Cellular Biology;next generation;novel;novel drug class;novel therapeutics;Organoids;Outcome;Patients;Peer Review;Physiological;Proteomics;Publishing;screening;small molecule;spheroids;Techniques;Technology;three dimensional cell culture;tissue culture;Tissue Model;Tissue Sample;tissue/cell culture;Tissues;transcriptomics

PROJECT_TITLE: Disease model design and evaluation


NIH_SPENDING_CATS: Chronic Pain;Genetics;Human Genome;Neurosciences;Pain Research;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: TRISTAN, CARLOS  (contact)

PROJECT_TERMS: Absence of pain sensation;addiction;Address;Afferent Neurons;Analgesics;Cell model;chronic pain;chronic pain management;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Dependovirus;drug development;Engineering;Epigenetic Process;epigenome;experimental study;Fingers;gene repression;Genes;Genetic study;Genomics;Goals;Guide RNA;Human;Human Genetics;human induced pluripotent stem cells;In Vitro;in vivo;induced pluripotent stem cell;Inherited;inhibitor;innovation;loss of function mutation;mouse model;Mus;National Center for Advancing Translational Sciences;Nociception;Nociceptors;Opioid;Outcome Study;Pain;pain model;Promoter Regions;Proteins;Protocols documentation;Reagent;Repression;Risk;Serotyping;side effect;Sodium Channel;System;Testing;Therapeutic;transcriptome sequencing;transgene expression;Translations;Vertebral column;voltage;Zinc Fingers

PROJECT_TITLE: Optimization of Long-lasting Analgesia via Targeted Epigenetic Repression (LATER) for human use


NIH_SPENDING_CATS: Biotechnology;Neurosciences;Pain Research;Stem Cell Research;Stem Cell Research - Embryonic - Human

PROJECT_TERMS: Affect;Afferent Neurons;Agreement;Analgesics;assay development;axon growth;Biological Assay;Boston;Calcium;Cell Culture Techniques;cell type;Cells;Clinical Trials;Coculture Techniques;Collaborations;commercialization;Communities;Cyclic AMP-Dependent Protein Kinases;differentiation protocol;disease model;Electrophysiology (science);Film;Gene Expression Profile;Health;Human;Human Biology;Image;induced pluripotent stem cell;inflammatory pain;inhibitor;Injury;Legal patent;Licensing;Microglia;Modeling;Molecular;Motor Neurons;Mus;National Center for Advancing Translational Sciences;Neurites;Neuroglia;Neurons;Nociceptors;novel;outcome prediction;Pediatric Hospitals;Peripheral;Peripheral Nervous System Diseases;Pharmaceutical Preparations;pharmacologic;Phenotype;prevent;Proteomics;Protocols documentation;Publications;Publishing;Reporter;Reporting;Research;response;Schwann Cells;screening;Screening procedure;single cell analysis;stem cells;Time;transcriptome sequencing

PROJECT_TITLE: Characterization of human induced nociceptors produced by a novel iPSC differentiation protocol for disease modeling


NIH_SPENDING_CATS: Chronic Pain;Diabetes;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Precision Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

PROJECT_TERMS: Address;Afferent Neurons;Collaborations;diabetic;Diabetic Neuropathies;diabetic patient;differentiation protocol;Genetic;Goals;individual patient;induced pluripotent stem cell;Measures;multiple omics;National Center for Advancing Translational Sciences;Neuropathy;new therapeutic target;Nociceptors;Organoids;Pain;pain reduction;pain sensation;patient derived induced pluripotent stem cells;patient population;Patients;Peripheral Nervous System Diseases;Phenotype;Proteomics;Protocols documentation;Sensory;Stimulus;Testing;transcriptomics;Type 2 diabetic;Variant

PROJECT_TITLE: Multi-omic analysis of diabetic neuropathy in iPSC derived sensory neurons


NIH_SPENDING_CATS: Cancer;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Women's Health Research

PROJECT_TERMS: Adult;Affect;Afferent Neurons;Animal Model;axonal degeneration;Back;Cancer Patient;cancer therapy;Carboplatin;Cells;chemotherapy;Chemotherapy-induced peripheral neuropathy;Coculture Techniques;Collaborations;Collecting Cell;differential expression;Disease;dosage;Dose;effective therapy;Family member;Gap Junctions;Genetic;Human;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Intervention;Malignant Female Reproductive System Neoplasm;Manuscripts;Methods;mimetics;Modeling;Molecular;Morphology;Muscarinic Acetylcholine Receptor;National Center for Advancing Translational Sciences;Neuroglia;Newly Diagnosed;novel therapeutics;Paclitaxel;Pain;Pathologic;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Peripheral Nervous System Diseases;Physiological;plexin;Pluripotent Stem Cells;Predisposition;premature;prevent;Quality of life;receptor expression;research and development;Risk Factors;Rodent;Semaphorins;side effect;Signal Transduction;stem cells;Symptoms;taxane;therapy development

PROJECT_TITLE: Studies of Chemotherapy Induced Peripheral Neuropathy (CIPN) in iPSC-derived


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Chronic Pain;Natural Products;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

PROJECT_TERMS: 3-Dimensional;3D Print;Acceleration;Address;Afferent Neurons;Anatomy;Animal Model;Architecture;biocompatible polymer;biofabrication;Biological Assay;Biomedical Engineering;bioprinting;Capsaicin;Cell Differentiation process;Cell Line;Cell model;Cell Physiology;Cells;Cellular Assay;Cellular biology;Chemical Agents;Clinic;clinical development;Clinical Trials;Development;Disease;drug candidate;drug development;drug discovery;Drug Modelings;Drug Screening;drug structure;efficacy study;Electrophysiology (science);Engineering;Ensure;Failure;first-in-human;Genetic;Goals;Health;Helping to End Addiction Long-term;high throughput screening;Human;Human Biology;human model;human tissue;Hydrogels;IL4 gene;Immune;improved;In Vitro;in vivo;induced pluripotent stem cell;Infrastructure;Intervention;Lead;Libraries;manufacture;Measures;Methods;Modeling;Morphology;National Center for Advancing Translational Sciences;Nociceptors;Normal tissue morphology;novel;novel therapeutics;Opiate Addiction;opioid epidemic;opioid misuse;opioid use;Pain;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacology;Physiological;Physiology;pre-clinical;preclinical efficacy;Predictive Value;preservation;Printing;Process;programs;Protocols documentation;Pruritus;Public Health;Risk;safety study;Science;screening;Skin;Skin Tissue;small molecule libraries;Source;Stimulus;stressor;Techniques;Technology;Testing;Therapeutic;Tissue Engineering;Tissue Microarray;Tissues;Toxic effect;Translational Research;United States Food and Drug Administration;United States National Institutes of Health;Vascularization;Work

PROJECT_TITLE: Innervated 3D skin models for pain sensing


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Chronic Pain;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Peripheral Neuropathy;Substance Misuse

PROJECT_TERMS: 3-Dimensional;Acceleration;addiction;Address;Agonist;allodynia;Analgesics;Animal Model;Animals;antagonist;Binding;Biological Assay;Biology;bioprinting;Cell Line;Cell model;Chemicals;Chemistry;chronic itch;chronic pain;clinic ready;Clinical;Clinical Trials;Collaborations;design;Disease;drug candidate;efficacy study;Engineering;Extramural Activities;first-in-human;Genes;Genomics;Goals;Health;Helping to End Addiction Long-term;high throughput screening;Human;Human Biology;human model;human subject;improved;induced pluripotent stem cell;Infrastructure;Inherited;inhibitor;insight;Intervention;Investigational Drugs;Ion Channel;Ion Channel Gating;Lead;Libraries;Link;loss of function;loss of function mutation;Machine Learning;mechanical allodynia;Mechanics;Mechanoreceptors;Methodology;Modeling;nanobodies;National Center for Advancing Translational Sciences;novel;novel therapeutic intervention;novel therapeutics;Opiate Addiction;opioid epidemic;opioid misuse;opioid overdose;Overdose;Pain;Pain management;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Piezo 1 ion channel;Piezo 2 ion channel;pre-clinical;preclinical efficacy;Process;Pruritus;Public Health;Quantitative Structure-Activity Relationship;response;Risk;safety study;Science;screening;small molecule;stable cell line;Stretching;System;Tactile;Testing;Tissue Microarray;Tissues;tool;Touch sensation;Translational Research;Translations;United States Food and Drug Administration;United States National Institutes of Health;virtual;virtual screening;Work

PROJECT_TITLE: Chemical Modulators of the PIEZO2 Mechanoreceptor for the Study and Treatment of Pain


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Chronic Pain;Headaches;Migraine;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

PROJECT_TERMS: 3-Dimensional;Acceleration;addiction;Address;Affinity;Analgesics;Animal Model;Animals;antagonist;Antibodies;Biological Assay;Biology;bioprinting;Blood - brain barrier anatomy;Brain;Cell model;Cells;Chemicals;Chemistry;chronic pain;chronic pain management;clinic ready;Clinical;Clinical Trials;design;Disease;drug candidate;Effectiveness;efficacy study;Extramural Activities;first-in-human;Genomics;Health;Helping to End Addiction Long-term;high throughput screening;Human;Human Biology;human model;improved;induced pluripotent stem cell;Inflammatory;Infrastructure;insight;Intervention;Investigational Drugs;Lead;Methodology;Migraine;migraine treatment;Modeling;nanobodies;National Center for Advancing Translational Sciences;Neuropeptides;neutralizing antibody;nociceptin;novel;novel therapeutics;Opiate Addiction;opioid epidemic;opioid misuse;opioid overdose;Overdose;Pain;Patients;peptide P;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Play;pre-clinical;preclinical efficacy;prevent;Process;Public Health;receptor;response;Risk;Role;safety study;Science;screening;small molecule;Substance P;success;System;Testing;Tissue Microarray;Tissues;tool;Translational Research;Translations;United States Food and Drug Administration;United States National Institutes of Health;Work

PROJECT_TITLE: Developing Brain-penetrant Antibodies Against Substance P and CGRP Neuropeptides for Treatment of Migraines


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Natural Products;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

PROJECT_TERMS: 3-Dimensional;Absence of pain sensation;abuse liability;Acceleration;addiction;Address;Agonist;Analgesics;analog;Animal Model;Animals;antagonist;Binding;Biological Assay;Biological Models;Biology;bioprinting;blood-brain barrier crossing;Boston;Cell model;Cells;Chemicals;Chemistry;clinic ready;Clinical;Clinical Trials;Complex;Cryoelectron Microscopy;design;Development;Disease;drug candidate;druggable target;efficacy study;exhibitions;Extramural Activities;first-in-human;Galanin;galanin receptor;Galectin 1;GALR1 Galanin Receptor;Genomics;GTP-Binding Proteins;Health;Helping to End Addiction Long-term;high throughput screening;Human;Human Biology;human model;improved;induced pluripotent stem cell;Infrastructure;insight;International;Intervention;Investigational Drugs;Lead;lead optimization;lead series;Libraries;Ligand Binding;Ligands;Mediating;Medicine;Methodology;Methods;Midbrain structure;Modeling;mu opioid receptors;Mutagenesis;National Center for Advancing Translational Sciences;Natural Products;Neuropeptides;novel;novel therapeutics;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid overdose;Opioid Receptor;opioid use disorder;Overdose;Pain;Patients;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;positive allosteric modulator;pre-clinical;preclinical efficacy;Process;Public Health;receptor;response;Rewards;Risk;safety study;Science;screening;small molecule;Spinal Cord;Structure;Structure-Activity Relationship;symposium;System;Testing;Tissue Microarray;Tissues;tool;Translational Research;Translations;United States;United States Food and Drug Administration;United States National Institutes of Health;Work

PROJECT_TITLE: Targeting -opioid Receptor-Galanin Gal1 Receptor Heterodimers for the Treatment of Opioid Use Disorder (OUD)


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Natural Products;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Physical Injury - Accidents and Adverse Effects;Prescription Drug Misuse;Substance Misuse

PROJECT_TERMS: 3-Dimensional;Acceleration;addiction;Address;Analgesics;analog;Animal Model;Animals;beta-arrestin;Binding;Biological Assay;Biology;bioprinting;Cell model;Central Nervous System;Chemicals;Chemistry;clinic ready;Clinical;Clinical Trials;Collaborations;Data;design;Development;Disease;drug candidate;drug-like compound;efficacy study;Electrophysiology (science);Extramural Activities;first-in-human;G-Protein-Coupled Receptors;Genomics;Habenula;Health;Helping to End Addiction Long-term;high throughput screening;Human;Human Biology;human model;Immune system;improved;Individual;induced pluripotent stem cell;Infrastructure;insight;Intervention;Investigational Drugs;Lead;lead optimization;Libraries;long term abstinence;Manuscripts;Medial;Methodology;Modeling;Morphine;Motivation;mu opioid receptors;Mus;National Center for Advancing Translational Sciences;Natural Products;Neurons;novel;novel therapeutics;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid overdose;Orphan;Overdose;Oxycodone;Pain;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Play;pre-clinical;preclinical efficacy;Process;Property;Public Health;receptor;response;Risk;Role;safety study;Science;screening;Series;Structural Models;System;Testing;Tissue Microarray;Tissues;tool;Translational Research;Translations;United States Food and Drug Administration;United States National Institutes of Health;Work

PROJECT_TITLE: Development of Gpr151 Modulators for the Treatment of Opioid Dependence


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Chronic Pain;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Peripheral Neuropathy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

PROJECT_TERMS: 3-Dimensional;Acceleration;addiction;Address;Analgesics;analog;Animal Model;Animals;Biological Assay;Biological Availability;Biology;bioprinting;Cell model;Chemicals;Chemistry;Chemotherapy-induced peripheral neuropathy;chronic pain;chronic pain management;clinic ready;Clinical;clinical candidate;Clinical Trials;Collaborations;cytotoxicity;design;Disease;Docking;drug candidate;Drug Kinetics;efficacy study;Equilibrium;Extramural Activities;first-in-human;Genomics;Goals;Health;Helping to End Addiction Long-term;high throughput screening;Human;Human Biology;human induced pluripotent stem cells;human model;improved;induced pluripotent stem cell;Infrastructure;inhibitor;insight;Intervention;Investigational Drugs;Lead;lead series;Legal patent;Machine Learning;Medicine;Methodology;Microsomes;Modeling;National Center for Advancing Translational Sciences;Nociceptors;non-opioid analgesic;novel;novel therapeutics;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid overdose;Oral;Overdose;Pain;painful neuropathy;Patients;Periodicity;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;pharmacophore;pre-clinical;preclinical efficacy;Process;Public Health;Quality of life;Quantitative Structure-Activity Relationship;response;Risk;safety study;Science;screening;Sodium Channel;Sumoylation Pathway;Surface;System;Testing;Tissue Microarray;Tissues;tool;Translational Research;Translations;United States Food and Drug Administration;United States National Institutes of Health;virtual;virtual screening;voltage;Work

PROJECT_TITLE: Optimization of Allosteric Regulators of the NaV1.7 Sodium Channel for Chemotherapy-induced Peripheral Neuropathy (CIPN)


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Chronic Pain;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

PROJECT_TERMS: 3-Dimensional;Acceleration;addiction;Address;Affinity;Analgesics;Animal Model;Animals;Binding;Biological Assay;Biological Availability;Biology;bioprinting;Brain;Cell Membrane Permeability;Cell model;Chemicals;Chemistry;Clinic;clinic ready;Clinical;Clinical Trials;design;Disease;drug candidate;efficacy study;extracellular;Extramural Activities;first-in-human;FOLH1 gene;follow-up;Genomics;Glutamates;Health;Helping to End Addiction Long-term;high throughput screening;Human;Human Biology;human model;Hydrolysis;improved;induced pluripotent stem cell;Infrastructure;inhibitor;insight;Intervention;Investigational Drugs;Lead;Ligands;Liquid Chromatography;liquid chromatography mass spectrometry;melting;Membrane;metalloenzyme;Methodology;Modeling;N-acetylaspartate;National Center for Advancing Translational Sciences;Neuropeptides;novel;novel therapeutics;Opiate Addiction;opioid epidemic;opioid misuse;opioid overdose;Oral;Overdose;Pain;Pain management;pain sensation;Patients;Penetration;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;pilot test;Powder dose form;pre-clinical;preclinical efficacy;Process;Public Health;Radioactivity;response;Risk;Running;safety study;Science;screening;small molecule;small molecule inhibitor;Stream;System;tandem mass spectrometry;Testing;Tissue Microarray;Tissues;tool;Translational Research;Translations;transmission process;United States Food and Drug Administration;United States National Institutes of Health;Validation;Work;Zinc

PROJECT_TITLE: High Throughput Screen to Identify Glutamate Carboxypeptidase II (GCPII) Brain-Penetrable-Inhibitors for the Treatment of Pain


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Chronic Pain;Natural Products;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

PROJECT_TERMS: 3-Dimensional;Acceleration;addiction;Address;adenylyl cyclase 1;Analgesics;Animal Model;Animals;Binding;Binding Sites;Biological Assay;Biology;bioprinting;blood-brain barrier permeabilization;Cell model;Chemicals;Chemistry;Chronic inflammatory pain;chronic pain management;clinic ready;Clinical;Clinical Trials;Cyclic AMP;design;Development;Disease;drug candidate;efficacy study;Enzymes;Extramural Activities;first-in-human;Follow-Up Studies;Genomics;Health;Helping to End Addiction Long-term;high throughput screening;Human;Human Biology;human model;improved;induced pluripotent stem cell;Infrastructure;inhibitor;insight;Intervention;Investigational Drugs;Knockout Mice;Lead;Libraries;Literature;Methodology;miniaturize;Modeling;National Center for Advancing Translational Sciences;Natural Products;Neuronal Plasticity;Neurons;non-opioid analgesic;novel;novel therapeutics;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid overdose;Overdose;Pain;pain processing;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;pre-clinical;preclinical efficacy;preclinical study;Process;Public Health;Research;response;Rewards;Risk;safety study;Science;screening;Site;small molecule inhibitor;System;Testing;Tissue Microarray;Tissues;tool;Translational Research;Translations;United States Food and Drug Administration;United States National Institutes of Health;Work

PROJECT_TITLE: Adenylyl Cyclase 1 (AC1) Inhibitors as Opioid Alternatives for Chronic and Inflammatory Pain


PROJECT_TERMS: 3-Dimensional;Ablation;Acceleration;addiction;Address;Analgesics;analog;Animal Model;Animals;antagonist;atrial natriuretic factor receptor A;atrial natriuretic factor receptor B;Attenuated;Biological Assay;Biology;bioprinting;Cell Line;Cell model;Characteristics;Chemicals;Chemistry;clinic ready;Clinical;Clinical Trials;Collaborations;Data;design;Disease;drug candidate;Drug Kinetics;efficacy study;Extramural Activities;first-in-human;follow-up;Genomics;Goals;Health;Helping to End Addiction Long-term;high throughput screening;Human;Human Biology;human model;improved;induced pluripotent stem cell;Infrastructure;insight;Interneurons;Intervention;Investigational Drugs;Laboratories;Lead;Libraries;Ligand Binding;Methodology;Modeling;Mus;National Center for Advancing Translational Sciences;Natural Products;Neurons;novel;novel therapeutics;Opiate Addiction;opioid epidemic;opioid misuse;opioid overdose;Overdose;Pain;Patients;Perception;Peripheral;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;polypeptide;pre-clinical;preclinical efficacy;Preclinical Testing;Process;Pruritus;Public Health;receptor;response;Risk;safety study;saluretic;Science;screening;selective expression;Sensory Ganglia;Signal Pathway;small molecule;Source;Specificity;Spinal;Spinal Cord;System;Testing;Tissue Microarray;Tissues;tool;Translational Research;Translations;United States Food and Drug Administration;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: Npr1 Antagonists for Pain and Itch


PROJECT_TERMS: Active Sites;Affinity;Amides;Anabolism;analog;Animals;Anti-malarials;Aromatic Amino Acids;Bacteria;Basic Science;Binding;Binding Sites;Biological;Biological Assay;Biotechnology;Boston;Caenorhabditis elegans;Categories;Cell Membrane Permeability;Cells;Chemicals;Chemistry;Chorismate Mutase;Collaborations;Cyclic Peptides;design;Development;Disease;Economic Burden;Enzymes;Fermentation;fungus;Goals;Health;improved;In Vitro;in vivo;Infectious Agent;inhibitor;insight;interfacial;Kansas;Laboratories;Lead;Libraries;Ligands;marine;Mediating;Medicine;membrane activity;Metabolic;Methodology;Michigan;microorganism;Modality;model organism;Molecular;Natural product discovery;natural product inspired;Natural Products;Nature;Nematoda;novel;Organism;Orthologous Gene;pathogen;Pathogenesis;pathogenic microbe;Pathogenicity;Pathway interactions;Peptide Library;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;Phase;Plants;Plasmodium falciparum;programs;Property;Publishing;repository;Resistance;Resources;screening;shikimate;Source;Staphylococcus aureus;Structure;Structure-Activity Relationship;System;Testing;Therapeutic;Tokyo;Translations;Tuberculosis;Universities;Virulence Factors;Work

PROJECT_TITLE: Discovery and Design of Novel Molecular Modalities for Chemical Probe and Therapeutic Lead Discovery


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

PROJECT_TERMS: Adopted;Automobile Driving;Basic Science;Biochemical;Biological Assay;cancer clinical trial;Cell membrane;Cell Physiology;Cells;Colorectal;cytotoxic;Diffuse intrinsic pontine glioma;drug candidate;Early Endosome;Endosomes;Goals;Health;high throughput screening;Human;Human Genome;improved;inhibitor;Malignant Neoplasms;National Center for Advancing Translational Sciences;Neuroblastoma;Oncology;Pancreas;Performance;pharmacologic;Play;Polyamines;polycation;programs;Proteins;Putrescine;Rare Diseases;Recycling;Reporting;Research;Role;small molecule;Specificity;Spermidine;Spermine;System;tool;trafficking;Translations;tumorigenic;uptake;Work

PROJECT_TITLE: Identification of inhibitors of the polyamine transporter ATP13A3


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Immunotherapy;Neurodegenerative;Neurosciences

PROJECT_TERMS: Adopted;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid;antagonist;Automobile Driving;Basic Science;Binding;Biological Assay;Brain;Cognitive;Dementia;Deposition;Development;Disease;drug candidate;Excision;Goals;Health;high throughput screening;Human;Human Genome;immunotherapy clinical trials;improved;Intervention;Measures;Messenger RNA;miniaturize;National Center for Advancing Translational Sciences;Neurons;Pathologic;Pathology;pharmacologic;Poly(A)+ RNA;Polyadenylation;Predisposition;preservation;programs;Property;Rare Diseases;Research;RNA Binding;Severities;small molecule;small molecule inhibitor;targeted treatment;tau Proteins;Tauopathies;Therapeutic;therapeutic effectiveness;tool;Toxic effect;Translations;Work

PROJECT_TITLE: Targeting MSUT2 binding to polyA mRNA for Alzheimer's disease


PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Automobile Driving;Basic Science;Biological Assay;Cell Therapy;Cells;design;Disease;drug candidate;Endosomes;Enzymes;Gaucher Disease;Generations;Health;Human;Human Genome;improved;Lipids;Measurement;Measures;Membrane;Minor;molecular modeling;National Center for Advancing Translational Sciences;novel;Pharmaceutical Chemistry;pharmacologic;phosphatidylinositol 4-phosphate;Phospholipids;Phosphotransferases;PIK3CG gene;programs;Rare Diseases;Research;small molecule;Specificity;Study models;tool;trafficking;Translations

PROJECT_TITLE: Identification of small molecules for PI4K2a BRET measurements


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: 2019-nCoV;Acceleration;Binding;Complex;Cryoelectron Microscopy;drug development;Future;Generations;Goals;Image;insight;interest;Methods;Molecular Weight;Mutation;nanobodies;National Center for Advancing Translational Sciences;Procedures;protein complex;protein structure;Proteins;System

PROJECT_TITLE: Incorporating NCATS' single-domain antibodies into the Legobody system


PROJECT_TERMS: Adopted;Anti-Inflammatory Agents;antimicrobial;Binding;Blood Vessels;CD47 gene;Cells;Generations;Goals;Immune;Immune response;Inflammatory;Innate Immune Response;Macrophage;nanobodies;National Center for Advancing Translational Sciences;neoplastic cell;pathogenic bacteria;Phenotype;programmed cell death ligand 1;programs;response;Therapeutic;Tissues;tumor;Tumor-associated macrophages;wound healing

PROJECT_TITLE: Discovery of single-domain antibodies targeting CD206


PROJECT_TITLE: Discovery of single-domain antibodies targeting MFSD8


NIH_SPENDING_CATS: Aging

PROJECT_TITLE: Discovery of single-domain antibodies targeting fibril plaques


NIH_SPENDING_CATS: Neurosciences;Rare Diseases

PROJECT_TERMS: Automobile Driving;Basic Science;Biological Assay;Carrier Proteins;Cryoelectron Microscopy;deafness;Development;Disease;Drosophila genus;drug candidate;Family;Glutamates;Goals;Health;Human;Human Genome;improved;In Vitro;in vivo;insight;interest;member;Mutation;nanobodies;National Center for Advancing Translational Sciences;Neurons;pharmacologic;programs;Proteins;Rare Diseases;Research;Structure;Synaptic Vesicles;therapeutic development;tool;Translations;Transportation

PROJECT_TITLE: Discovery of single-domain antibodies targeting VGLUT


PROJECT_TERMS: Automobile Driving;Basic Science;Cryoelectron Microscopy;Disease;Disease Progression;drug candidate;Gene Silencing;Goals;Health;Human;Human Genome;Image;improved;Missense Mutation;Muscular Dystrophies;Mutation;nanobodies;National Center for Advancing Translational Sciences;pharmacologic;programs;Proteins;Rare Diseases;Research;Research Personnel;Resolution;Testing;tool;Translations

PROJECT_TITLE: Discovery of single-domain antibodies targeting SMCHD1


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

PROJECT_TERMS: Automobile Driving;Basic Science;Cells;drug candidate;Dysplasia;Goals;Health;Hip region structure;Human;Human Genome;improved;Ion Channel;Molecular Conformation;Movement;Mutation;nanobodies;nanodisk;National Center for Advancing Translational Sciences;pharmacologic;Piezo 2 ion channel;programs;Proteins;Protocols documentation;Rare Diseases;Research;scoliosis;skeletal abnormality;tool;Touch sensation;Translations

PROJECT_TITLE: Discovery of single-domain antibodies targeting Piezo2


NIH_SPENDING_CATS: Rare Diseases

PROJECT_TERMS: Automobile Driving;Basic Science;Cryoelectron Microscopy;Diacylglycerol Kinase;Disease;drug candidate;Enzymes;flexibility;Goals;Health;Human;Human body;Human Genome;Image;improved;Methods;Movement;nanobodies;National Center for Advancing Translational Sciences;pharmacologic;Phosphotransferases;programs;Proteins;Rare Diseases;Research;Resolution;Tertiary Protein Structure;tool;Translations

PROJECT_TITLE: Discovery of single-domain antibodies targeting DGKq


PROJECT_TERMS: Antigen Presentation Pathway;antigenic peptide transporter;ATP-Binding Cassette Transporters;Automobile Driving;Basic Science;Biological Assay;CD8B1 gene;Cell surface;Cells;clinical application;Collaborations;Complex;Cytosol;drug candidate;Endoplasmic Reticulum;Family;Goals;Health;Human;Human Genome;Immunity;improved;inhibitor;Libraries;Major Histocompatibility Complex;Membrane;National Center for Advancing Translational Sciences;National Institute of Allergy and Infectious Disease;Nuclear Pore Complex;Peptide Transport;Peptides;pharmacologic;Play;programs;protein complex;Proteins;Rare Diseases;Reporting;Research;Role;Sampling;screening;small molecule inhibitor;small molecule libraries;Surveys;T-Lymphocyte;TAP1 gene;TAP2 gene;tool;Translations

PROJECT_TITLE: Identification of small molecule inhibitors of TAP protein


PROJECT_TERMS: Ablation;antagonist;Appetite Stimulants;blood glucose regulation;Data;Diabetes Mellitus;Energy Metabolism;Enteroendocrine Cell;experimental study;G-Protein-Coupled Receptors;Genetic;Glucose;glucose tolerance;Goals;GPR17 gene;gut-brain axis;Hypothalamic structure;improved;Insulin;insulin secretion;Intervention;intestinal epithelium;Leptin;Ligands;Manuscripts;Medical;Neurons;Obesity;Orphan;Peptides;receptor;reduced food intake;Reporting;Role;screening;Signal Transduction;small molecule;small molecule libraries;Writing

PROJECT_TITLE: Identification of small molecule antagonist of GPR17 receptor


NIH_SPENDING_CATS: Cancer;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

PROJECT_TERMS: Antibody-drug conjugates;Automobile Driving;Basic Science;BCL2 gene;BRCA mutations;cancer cell;Cancer cell line;Cells;Data;drug candidate;Goals;Health;Human;Human Genome;improved;inhibitor;Libraries;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;mutant;National Center for Advancing Translational Sciences;Pathway interactions;Patients;pharmacologic;Poly(ADP-ribose) Polymerase Inhibitor;programs;Proteins;Rare Diseases;Reporting;Research;Resistance;Resistance development;screening;small molecule;synergism;tool;Translations;Treatment Efficacy

PROJECT_TITLE: Identification of IMMU-132-synergistic small molecules in Olaparib-resistant ovarian cancer cells


ACTIVITY: ZIC

ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Dental, Oral, and Craniofacial Disease;Genetics

PI_NAMEs: SZABO, ROMAN  (contact)

PROJECT_TERMS: Archives;Clustered Regularly Interspaced Short Palindromic Repeats;Consultations;Cryopreservation;Derivation procedure;Electroporation;Embryo;Embryo Transfer;experimental study;Fertilization in Vitro;gain of function;gene editing technology;Gene Modified;Gene Targeting;Generations;Genes;Injections;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Location;loss of function;mouse model;Mouse Strains;Mus;National Institute of Dental and Craniofacial Research;Operative Surgical Procedures;preservation;Principal Investigator;Research;Research Personnel;Services;Shipping;sperm cell;sperm cryopreservation;Transgenic Organisms

PROJECT_TITLE: Gene Targeting Core, NIDCR DIR


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PI_NAMEs: MAHADEVAN, VIVEK  (contact)

PROJECT_TERMS: base;Bioinformatics;bioinformatics tool;Biological Assay;Biological Sciences;bisulfite sequencing;Cells;ChIP-seq;Chromium;Collaborations;Communities;computerized data processing;Core Facility;Counseling;Custom;Data;Data Analyses;Data Collection;design;Diagnosis;differential expression;Dissociation;DNA;DNA Sequence;DNA sequencing;DNA Sequencing Facility;exome;exome sequencing;Generations;Genes;Genetic Research;genome sequencing;Genomics;Hereditary Disease;Image;innovation;Ions;Libraries;methylome;microbiome sequencing;MicroRNAs;miRNA expression profiling;Mission;Molecular;National Institute of Child Health and Human Development;next generation sequencing;Production;Research;Research Personnel;ribosome profiling;RNA;Running;Sampling;Services;single cell ATAC-seq;single molecule;single-cell RNA sequencing;Sulfate;targeted exome sequencing;Technology;technology platform;transcriptome sequencing;transcriptomics;Update;Variant;whole genome

PROJECT_TITLE: Molecular Genomics Sequencing Core Facility


ACTIVITY: ZIG

ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

PI_NAMEs: LOVINGER, DAVID M (contact)

PROJECT_TERMS: Accreditation;Anesthesia procedures;animal care;Animal Care and Use Committees;Animal Experimentation;Animal Husbandry;Animal Welfare;Animals;Area;biological research;Breeding;Clinical Research;Communicable Diseases;Communities;comparative;Containment;Cryopreservation;Derivation procedure;Development;disease diagnosis;Ensure;environmental enrichment for laboratory animals;Equipment;Euthanasia;Evaluation;Food;hazard;Health;Healthcare;Hemorrhage;Hour;Injections;International;Intramural Research Program;Laboratory Animal Science;Laboratory Animals;Logistics;Maryland;Medicine;Mission;model development;Modification;Monitor;Mus;National Institute on Alcohol Abuse and Alcoholism;Operative Surgical Procedures;Oral;Participant;Pathologic;Phenotype;Play;Policies;policy recommendation;Preparation;Principal Investigator;Procedures;programs;Rattus;Regulation;Research;Research Personnel;Research Support;restraint;Role;sample collection;Services;Substance administration;Tissue Banks;Training;United States National Institutes of Health;Veterinarians;Water;Weaning

PROJECT_TITLE: Office of Laboratory Animal Science


ADMINISTERING_IC: FD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: HONOLULU

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: QUEEN'S MEDICAL CENTER

ORG_STATE: HI

PHR: Project Narrative Our project will create a “Hawai‘i Health Equity Research and Outreach Network (HAWAI‘I HERON)” that will provide resources to support efforts to improve health equity for Asian American, Native Hawaiian and other Pacific Islander (AA-NHPI) populations. This work will be in collaboration with the Food and Drug Administration and other minority-serving institutions and will include a pilot study examining AA-NHPI patient preferences for diabetes medications. HAWAI‘I HERON has the potential to strengthen health equity focused research, outreach and communications, and training and mentoring of diverse students and junior researchers.

PI_NAMEs: SETO, TODD B (contact);TAIRA, DEBORAH ANN

PROGRAM_OFFICER_NAME: LEE, CHRISTINE


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

ORG_STATE: MD

PI_NAMEs: HEIMBROOK, DAVID  (contact)

PROJECT_TERMS: Amendment;American College of Radiology Imaging Network;Annual Reports;Authorization documentation;Back;bench to bedside;Biological;Blood;Brain Neoplasms;cancer Biomedical Informatics Grid;cancer imaging;cancer therapy;Cetuximab;Clinical;clinical center;Clinical Data;clinical database;Clinical Research;Clinical Trials;Collaborations;Communities;computer-assisted diagnostics;Contracts;Contrast Media;Cyclotrons;data management;Databases;Decision Making;Dedications;Deoxycytidine;Development;Diagnosis;diagnostic tool;drug development;early phase clinical trial;Education and Outreach;Educational workshop;Estrogen Receptors;Ferumoxtran-10;ferumoxytol;Goals;Growth;Half-Life;Hypoxia;Image;imaging agent;imaging informatics;imaging platform;imaging program;Informatics;infrastructure development;innovation;interest;Internet;Investigation;Investigational Drugs;Joints;Letters;lymph nodes;Magnetic Resonance Imaging;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant Neoplasms;Manufacturer;Medical;Medical Imaging;meetings;Metastatic breast cancer;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Mission;Modality;molecular imaging;Monitor;outreach;Pamphlets;patient stratification;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Positioning Attribute;preclinical study;Preparation;Procedures;Program Development;programs;Proliferating;Radiopharmaceuticals;Regulatory Affairs;Reporting;Research;Research Personnel;Scientific Societies;Serious Adverse Event;single photon emission computed tomography;Site;Systems Biology;Testing;Tetrahydrouridine;text searching;The Cancer Imaging Archive;Therapeutic;therapeutic development;Thymidine;tomography;Tracer;Translations;treatment response;United States National Institutes of Health;virtual;Work;Writing

PROJECT_TITLE: DCTD Cancer Imaging


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Hepatitis - C;Infectious Diseases;Liver Disease;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PI_NAMEs: SLAYDEN, RICHARD  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Animal Model;Basic Science;Clinical Trials;Collaborations;Communities;Contracts;Development;Devices;Drug Combinations;drug testing;Extramural Activities;Hepatitis B Virus;Hepatitis C virus;HIV;Investigational New Drug Application;Investigator-Initiated Research;Licensure;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis complex;National Institute of Allergy and Infectious Disease;novel therapeutics;pre-clinical;Private Sector;product development;repository;Research;research clinical testing;research study;Resources;Services;Testing;Therapeutic;therapeutic development;United States Food and Drug Administration;Work

PROJECT_TITLE: Testing of Drug Combinations For Mycobacterium tuberculosis (MTB) in Mice


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PI_NAMEs: DENNY, THOMAS  (contact)

PROJECT_TERMS: Accreditation;Acquired Immunodeficiency Syndrome;Biological;Biological Assay;Biometry;CD4 Positive T Lymphocytes;Clinical;Clinical Research;comorbidity;computerized;Contracts;Cryopreservation;Data;Data Management Resources;data submission;Educational workshop;electronic data;European;Evaluation Methodology;Freezing;Funding;HIV Seropositivity;HIV/AIDS;Human;Immunologic Tests;Immunologics;Immunology;Immunology procedure;International;Laboratories;Leukapheresis;Libraries;Medicine;Methodology;Monitor;National Institute of Allergy and Infectious Disease;performance tests;Peripheral Blood Mononuclear Cell;Plasma;Prevention;Process;programs;Qualifying;Quality Control;Reagent;Resources;Respondent;Sampling;Site;Specific qualifier value;Standardization;Support Contracts;Testing;Training;United States Food and Drug Administration;Validation;Viral Load result;Whole Blood

PROJECT_TITLE: Immunology Quality Assessment (IQA) Program


NIH_SPENDING_CATS: Data Science;HIV/AIDS;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Authorization documentation;biobank;Catalogs;Clinical Data;cloud based;Cloud Service;Communities;Contracts;dashboard;Data;data access;Data Collection;data dashboard;data ecosystem;data hub;data management;data repository;data resource;Data Science;Data Set;data sharing;Data Storage and Retrieval;data tools;diverse data;Documentation;Extramural Activities;FAIR principles;Funding;Generations;Goals;Human;Individual;Information Systems;International;Intramural Research;Intuition;Investments;Link;Location;Medical center;Metadata;Modernization;National Institute of Child Health and Human Development;Office of Administrative Management;online resource;Participant;Policies;population health;Privacy;Publications;rehabilitation research;Reporting;Reproducibility;Research;research and development;Research Personnel;research study;Research Support;Resources;secondary analysis;Secure;Specimen;Strategic Planning;System;tool;United States National Institutes of Health;usability;web app;web services

PROJECT_TITLE: NICHD DATA AND SPECIMEN HUB (DASH) MODERNIZATION


ADMINISTERING_IC: DK

FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Social Determinants of Health

PROJECT_TERMS: Affect;authority;Businesses;Caring;Characteristics;clinical care;Communication;Communities;community organizations;Complications of Diabetes Mellitus;Counseling;Deductibles;design;diabetes management;Diabetes Mellitus;diabetes risk;diabetogenic;Diet;Disparity;disparity reduction;Effectiveness;Environment;Epidemic;Evaluation;evidence base;experimental study;Funding;Glucose;Goals;Health;Health behavior;health care model;health care service organization;health goals;health plan;Health system;Healthcare;Home;improved;innovation;Intervention;Local Government;Logistics;Medicaid;Modeling;Natural experiment;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Observational Study;payment;Persons;Physical activity;Play;Policies;Population;Prediabetes syndrome;prevent;Prevention;primary care setting;Productivity;Program Evaluation;programs;Public Health;Research;response;Risk Factors;social health determinants;System;Target Populations;Translations;Work

PROJECT_TITLE: Interdepartmental Designation of Authority (IDDA) NEXT-D3


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: SAN JOSE

ORG_NAME: CCS ASSOCIATES, INC.

ORG_STATE: CA

PI_NAMEs: SIGMAN, CAROLINE  (contact)

PROJECT_TITLE: PROVIDE A VARIETY OF CRITICAL CANCER PREVENTION INFORMATION MANAGEMENT FUNCTIONS


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Neurosciences

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PHR: Developing therapies for neurological disorders

PI_NAMEs: GREEN, CAROL E (contact)

PROJECT_TERMS: Animal Welfare;Award;bench to bedside;Biological Products;Chemistry;Client;Contractor;Contracts;design;Dosage Forms;Equipment;experience;flexibility;Formulation;good laboratory practice;Good Manufacturing Process;Heart Diseases;Hematological Disease;International;Laboratory Animals;Lung Diseases;manufacture;member;Modernization;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Drug Abuse;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;novel;novel therapeutics;Office for Human Research Protections;operation;Pharmacologic Substance;Pharmacology;Principal Investigator;Production;programs;Qualifying;Regulation;Request for Proposals;research and development;Resources;response;Science;Scientist;screening;Services;small molecule;small molecule therapeutics;Testing;therapy development;Toxicology;Translational Research;United States Food and Drug Administration;United States National Institutes of Health;Work

PROJECT_TITLE: IGF::OT::IGF TASK ORDER #001  PERFORMANCE AREA 1  MANAGEMENT AND OPERATIONS SUPPORT


FUNDING_MECHANISM: SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHALFONT

ORG_NAME: POLYGON HEALTH ANALYTICS LLC

ORG_STATE: PA

PI_NAMEs: YAO, LIXIA  (contact)

PROJECT_TERMS: anti-cancer research;Clinical;Clinical Data;clinical practice;cloud based;commercialization;Computer software;Data;Data Analyses;Data Commons;data modeling;design;Development;Diagnosis;efficacious treatment;Genomics;Goals;Health;Image;innovation;insight;Knowledge;Malignant Neoplasms;multimodal data;Multiomic Data;Natural Language Processing;Ontology;Pathology;Pathology Report;petabyte;Phase;prototype;repository;risk stratification;Scanning;Small Business Innovation Research Grant;Specific qualifier value;Squamous cell carcinoma;The Cancer Genome Atlas;tool;user-friendly

PROJECT_TITLE: TOPIC NUMBER:  464 SBIR PHASE ICLOUD-BASED MULTIMODAL DATA ANALYSIS SOFTWARE FOR THE CANCER RESEARCH DATA COMMONS


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Cancer

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PI_NAMEs: WANG, XIAO-JING  (contact)

PROGRAM_OFFICER_NAME: HUBBARD, LEAH

PROJECT_TITLE: Treating recurrent HNSCC with radiation and dual TGF-Beta/PD-L1.


NIH_SPENDING_CATS: Bioengineering;Cancer;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: AUSTIN

ORG_NAME: ANACONDA, INC

ORG_STATE: TX

PI_NAMEs: BEDNAR, JAMES  (contact)

PROJECT_TERMS: Address;anti-cancer research;Awareness;Big Data;cancer type;Cells;Clinical Research;Collaborations;Communication;Communities;Complement;Complex;Computer software;Data;data access;Data Analyses;Data Commons;data exploration;Data Files;Data Science;Data Set;data visualization;Development Plans;Dimensions;flexibility;Foundations;Funding;improved;Individual;insight;interactive visualization;large datasets;Libraries;Malignant Neoplasms;Modality;multidimensional data;multimodal data;multimodality;open data;open source;patient population;Performance;Phase;prototype;Pythons;Reproducibility;Research;Research Personnel;Sampling;software development;Source;Specific qualifier value;symposium;Techniques;Testing;Text;tool;Training;usability;Visualization;Visualization software;web app;web site;Work

PROJECT_TITLE: TOPIC 464: CLOUD-BASED MULTIMODAL DATA ANALYSIS SOFTWARE FOR THE CANCER RESEARCH DATA COMMONS


NIH_SPENDING_CATS: Cancer;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: PRINCETON

ORG_NAME: IMPACT BUSINESS INFORMATION SOLUTIONS INC.

ORG_STATE: NJ

PI_NAMEs: KRISHNAMOORTHY, RAJ  (contact)

PROJECT_TERMS: Address;Adopted;Clinical Data;cloud based;cohort;Data;Data Commons;data de-identification;data harmonization;data integration;data privacy;data resource;Data Set;Development;Ecosystem;Encapsulated;Environment;Genomic Data Commons;Genomics;Healthcare;hospital organization;Hospitals;Image;indexing;Metadata;Modality;Modeling;multimodal data;multimodality;Patients;Phase;Production;prototype;Public Domains;Radiology Specialty;Records;repository;Research;Research Personnel;Retrieval;Security;Small Business Innovation Research Grant;Testing;Textiles;Training

PROJECT_TITLE: TOPIC NUMBER: 464 SBIR PHASE I - UNIFIED DATA COMMONS SOLUTION FOR PUBLIC DOMAIN,IN-HOUSE AND THIRD-PARTY MULTIMODAL CLINICAL DATA.


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PI_NAMEs: LI, YONG  (contact)

PROGRAM_OFFICER_NAME: VLAD, ANDA MIOARA

PROJECT_TITLE: Administrative Core


ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PI_NAMEs: MAITRA, ANIRBAN  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TITLE: TBEL Admin Core


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Cancer;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: RESTON

ORG_NAME: CARAHSOFT TECHNOLOGY CORPORATION

ORG_STATE: VA

PI_NAMEs: DRINKWINE, TERRY  (contact)

PROGRAM_OFFICER_NAME: WEBER, MICHAEL NICHOLAS N

PROJECT_TERMS: Acceleration;Address;Biomedical Research;Cloud Computing;Cloud Service;cloud storage;Communities;computerized tools;Data;Data Commons;data ecosystem;data repository;Data Science;Data Set;Economics;FAIR principles;Funding;Goals;Image;Individual;large datasets;Modeling;Modernization;Phase;Policies;Procedures;Process;programs;Research Infrastructure;Research Personnel;Science;Series;service providers;Services;Strategic Planning;Technology;Testing;United States National Institutes of Health;Work

PROJECT_TITLE: STRIDES


NIH_SPENDING_CATS: Cancer;Data Science;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHANTILLY

ORG_NAME: FOUR POINTS TECHNOLOGY, LLC

PI_NAMEs: LIPKIN, JOEL A (contact)


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: OVERALL PROJECT NARRATIVE Physicians currently lack robust and reliable personalized tools to guide patient management in a landscape of expanded adjuvant immune checkpoint inhibition (ICI) treatment. The NYU Melanoma SPORE is directed at discovering, refining, and validating predictive and prognostic biomarkers for high-risk resected melanoma patients considering ICI treatment. The successful validation of these novel biomarkers has immense potential to improve melanoma patient clinical management and outcomes and could be extended to the increasing number of cancers treated with ICI.

PI_NAMEs: OSMAN, IMAN  (contact);WEBER, JEFFREY S

PROGRAM_OFFICER_NAME: KUZMIN, IGOR A

PROJECT_TERMS: Address;Adjuvant;Adjuvant Study;Adjuvant Therapy;Area;Autoantibodies;Award;Biology;biomarker identification;Cancer Patient;checkpoint inhibition;Clinical;clinical care;clinical development;Clinical Management;Custom;Data;expectation;Funding;Genetic Transcription;genomic biomarker;high risk;Immune;Immunobiology;Immunologic Adjuvants;Immunotherapy;improved;Infrastructure;insight;Maintenance;Malignant Neoplasms;Melanoma;Melanoma patient;Modality;mouse model;multiple omics;New York;novel;novel marker;optimal treatments;Organ;Outcome;Paper;patient biomarkers;patient response;Patient-Focused Outcomes;Patients;Peripheral;personalized biomarkers;Physicians;pre-clinical;predictive marker;Prognostic Marker;programs;Publications;Publishing;Recurrence;Research Project Grants;Resected;Resources;response;response biomarker;Science;Selection for Treatments;Serum;Site;success;SYK gene;T-Lymphocyte;therapeutic evaluation;Tissues;tool;Toxic effect;Treatment-related toxicity;Universities;Validation;Work

PROJECT_TITLE: NYU Melanoma SPORE


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PI_NAMEs: MOAVEN, OMEED  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Antibodies;anticancer activity;Area;Biomedical Engineering;cancer immunotherapy;checkpoint inhibition;chemotherapy;Clinical Trials Design;conventional therapy;design;Disease;Enzymes;Excision;Extracellular Matrix;fighting;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immune system;Immunologics;Immunooncology;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;interest;Malignant neoplasm of pancreas;Malignant Neoplasms;Modality;multimodality;Nature;neoplastic cell;novel;Oncology;Oncolytic viruses;Operative Surgical Procedures;pancreatic cancer patients;Patients;PD-1 inhibitors;Pre-Clinical Model;prevent;Recommendation;Recurrence;Research;Resistance;resistance mechanism;response;Safety;Solid Neoplasm;therapy resistant;Toxic effect;Treatment Efficacy;tumor;Tumor Escape;tumor microenvironment;Vertebral column;Vesicular stomatitis Indiana virus;Viral

PROJECT_TITLE: A novel oncolytic virus for pancreatic cancer immunotherapy


ORG_CITY: YEMASSEE

ORG_NAME: ALPHA GENESIS INC

ORG_STATE: SC

PI_NAMEs: WESTERGAARD, GREG  (contact)

PROJECT_TERMS: Accreditation;aged;animal care;Animals;Breeding;Caring;clinical translation;Communicable Diseases;Contractor;cooperative study;Ethics;Funding;Genetic;genetic pedigree;Genetic Variation;germ free condition;Government;Human;Immunology;Individual;Infrastructure;Institution;International;Laboratory Animals;Macaca;Macaca fascicularis;Macaca mulatta;Maintenance;Major Histocompatibility Complex;Medical;Modeling;Monkeys;National Institute of Allergy and Infectious Disease;nonhuman primate;novel therapeutics;operation;Physiology;Research;Research Personnel;Risk;sound;Testing;Therapeutic immunosuppression;Transplantation;Transplantation Tolerance

PROJECT_TITLE: NIAID SPF MACAQUE BREEDING COLONIES