PHR: NARRATIVE Homology-directed repair that is dependent on the tumor suppressors BRCA1-BARD1 and BRCA2 is the most conservative pathway to repair chromosomal breaks and damaged replication forks and is also needed for the preservation of stressed replication forks against attrition. When this pathway is lost, then cell transformation and cancer can occur. This shared resource of the Program, termed Chromosomal and Replication Analysis (CRA) Core, is directed by an experienced, NCI RO1- funded researcher in the field and will help investigators define the DNA replication, chromosomal and cellular outcomes when key regulators of the most important steps in HDR become dysfunctional. 1

PI_NAMEs: HROMAS, ROBERT A (contact)

PROJECT_TERMS: Aneuploidy;Attenuated;BARD1 gene;Binding;Biochemical;Biological;Biological Assay;brca gene;BRCA1 gene;BRCA2 gene;BRCA2 Mutation;Breast;Cancer Patient;Cell Cycle;Cell Cycle Progression;Cell Line;Cell model;Cell Survival;cell transformation;Cells;Chromosomal Breaks;Chromosomal Instability;Chromosomal Stability;Chromosomal translocation;Chromosome abnormality;chromosome replication;Chromosome Structures;Chromosomes;clinically relevant;Complex;CRISPR/Cas technology;Cytogenetic Analysis;Cytogenetics;Data;DNA;DNA Binding;DNA biosynthesis;DNA Double Strand Break;DNA fiber assay;DNA Repair;DNA Replication Damage;DNA replication fork;Double Strand Break Repair;Ensure;Epigenetic Process;Event;Excision;EXO1 gene;experience;Failure;Filament;Functional disorder;Funding;G-Banding;G1 Phase;gene editing technology;Gene Mutation;Genes;Genome;Hereditary Disease;Histones;Immunofluorescence Immunologic;Impairment;inhibitor;Invaded;Knock-in;Lead;Malignant Neoplasms;Measures;Mediating;Metaphase;Microscopy;Mitotic;Modification;mutant;Mutate;Mutation;Neoplastic Cell Transformation;Nonhomologous DNA End Joining;nuclease;Nucleoproteins;Outcome;Ovarian;p53-binding protein 1;Pathway interactions;Phase;Phenotype;postmitotic;preservation;Process;Program Research Project Grants;programs;Prostate;protein complex;Proteins;Rad51 recombinase;Reader;recruit;Regulation;Repair Complex;repaired;replication stress;Reporter;Reporting;Research Personnel;Research Project Grants;Resistance development;Resource Sharing;RNA Interference;Services;Single-Stranded DNA;small hairpin RNA;Small Interfering RNA;Stress;success;synergism;Tail;Translating;Tumor Suppressor Proteins;tumorigenesis

PROJECT_TITLE: Core 2: Chromosome Replication and Analysis (CRA) Core


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: SAN ANTONIO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Identification of the structure function relationships of intrinsically disordered proteins are central to understand- ing their biological function in homology directed repair (HDR) of DNA double strand breaks. The Structural Biology and Biophysics Core will provide atomic resolution mapping of critical protein-protein and protein-nucleic acid interactions of complexes important for HDR. The insights provided by the Core will assist Program Project Investigators in dissecting the mechanisms of 53BP1 regulation of 5’ strand resection and the formation of RAD51-ssDNA nucleoprotein fragments, processes important for HDR.

PI_NAMEs: LIBICH, DAVID STEVEN (contact)

PROJECT_TERMS: Address;Affinity;Amino Acids;Binding;Binding Proteins;Binding Sites;Biochemical;Biological Process;biophysical analysis;biophysical properties;biophysical techniques;Biophysics;Calorimetry;cancer cell;Cell Cycle;Cell Cycle Stage;Cells;Chromatin;Chromosomal Rearrangement;Collaborations;Complex;Consultations;Coupled;Cryoelectron Microscopy;Dana-Farber Cancer Institute;Data Analyses;design;Development;Disease;DNA;DNA Double Strand Break;DNA Repair;DNA replication fork;Double Strand Break Repair;Ensure;environmental agent;Epigenetic Process;Excision;Exposure to;Filament;G1 Phase;Genome;Health Sciences;Human;In Vitro;insight;Kinetics;Laboratories;Lasers;Leadership;Lesion;Ligands;light scattering;Link;Maps;Measures;Mediating;Methodology;Methods;Molecular;Molecular Sieve Chromatography;mutant;Nature;Nonhomologous DNA End Joining;Nucleic Acid Binding;nucleic acid binding protein;Nucleic Acids;Nucleoproteins;p53-binding protein 1;Pathway interactions;Photometry;Positioning Attribute;Preparation;Process;programs;Protein Analysis;protein complex;protein protein interaction;protein purification;protein structure;Proteins;Reader;Regulation;repaired;Research;Research Personnel;Research Project Grants;Resolution;Services;Single-Stranded DNA;Site;stoichiometry;Stretching;structural biology;Structure;Structure-Activity Relationship;Surface Plasmon Resonance;Techniques;Tertiary Protein Structure;Texas;Thermodynamics;Universities;Work;X-Ray Crystallography

PROJECT_TITLE: Core 3: Structural Biology and Biophysics (SBB) Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-H (J1)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health

ORG_CITY: BOSTON

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Informing mental health policy requires a broad array of skills and knowledge. The Harvard Training Program in Mental Health Policy seeks to train policy researchers, providing the knowledge and skills to inform and evaluate policy affecting individuals with mental illness, as well as to inspire pre- and post-doctoral trainees to devote their career to the study of mental health policy. The Program has successfully trained social scientists and clinicians who have expanded the evidence base for the field.

PI_NAMEs: COOK, BENJAMIN LE;HUSKAMP, HAIDEN A. (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TITLE: Health Policy Training Program: Promoting Outcomes, Quality, Equity and Diffusion of Advances

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (04)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging

ORG_CITY: LA JOLLA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The UC San Diego Department of Radiology is submitting a competitive renewal of its postdoctoral training program that focuses on developing clinician-scientists through a year of laboratory research followed by 32 weeks of protected research time during the subsequent 4 years of residency training. This program trains radiologists to become clinical-translational research faculty, who ultimately can be competitive for NIH grant funding, industry collaboration and entrepreneurship. Trainees will be supported by 12 radiology and 12 non‐ radiology mentors that together have 103 active grants and over $28M in grant support (current year funding).

PI_NAMEs: CHANG, ERIC Y;RAKOW-PENNER, REBECCA ANN (contact)

PROGRAM_OFFICER_NAME: ERIM, ZEYNEP

PROJECT_TITLE: Training Clinical Scientists in Radiological Imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-D (J1)]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: Columbus

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The research experience supported by this training grant enhances recruitment of DVMs into graduate programs or other research career tracks. This translates into an increased proportion of DVMs who ultimately pursue research-oriented careers in academia, government, and industry, thereby addressing the national need for veterinary scientists who are an essential component of our biomedical research force. We will build upon this trajectory by establishing a formal relationship between the training program and a unique component of the veterinary medical curriculum at the Ohio State University: Career Areas of Emphasis.

PI_NAMEs: OGLESBEE, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Advisory Committees;Agriculture;Animals;Appointment;Area;Basic Science;Biomedical Research;career;career development;certificate program;Collaborations;college;commercialization;Communication;Communities;comparative;Data;Development;disorder prevention;Educational Curriculum;Employment;Enrollment;Ensure;Environmental Science;epidemiology study;experience;Faculty;faculty mentor;Food;Goals;Government;Health;Human;Individual;Industry;Intellectual Property;interest;Journals;Life;Medical;Medical Education;Medical Students;Medicine;Mentors;Ohio;Oral;Positioning Attribute;posters;programs;Public Health;Publications;Publishing;Reproducibility;Research;Research Project Grants;Science;skills;Student Selections;Students;success;summer research;symposium;Training;Training Activity;Training Programs;translational study;Veterinarians;Veterinary Medicine

PROJECT_TITLE: Short term training for veterinary students

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-J (80)]


NIH_SPENDING_CATS: Mental Health;Pediatric

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: The Duke-North Carolina Central University (NCCU)-Interdisciplinary Postdoctoral Training Program in Child Psychiatric and Neurodevelopmental Conditions (DN-IPT) is a partnership between Duke University School of Medicine and North Carolina Central University which will provide two to three years of intensive postdoctoral interdisciplinary research training to MD, PhD, and MD/PhD recipients with a focus on child psychiatric and neurodevelopmental conditions, as well as the developmental origins of adult psychiatric disorders. The DN-IPT will provide Trainees with focused, rigorous, in-depth training in a) our central theme of an interdisciplinary, developmental neuroscience research approach; and b) one or more of five research methodologies to interrogate this theme: (1) brain imaging; (2) computational approaches; (3) digital health; (4) interventions; and (5) preclinical models with an emphasis on enhancing diversity, equity, and inclusion at all phases of the research process.

PI_NAMEs: DAWSON, GERALDINE ;LEE, JU-AHNG ;POSNER, JONATHAN E (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Child;North Carolina;post-doctoral training;programs;Training Programs;Universities

PROJECT_TITLE: Duke-North Carolina Central University (NCCU)-Interdisciplinary Postdoctoral Training Program in Child Psychiatric and Neurodevelopmental Conditions Program (DN-IPT)

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (01)]


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Eye Disease and Disorders of Vision;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The goal of the proposed training program is to prepare students for careers as highly creative, inquisitive and productive scientists. We seek to provide the trainees, who are pursuing their PhD in Neuroscience, with broad- based interdisciplinary training relevant to understanding a variety of diseases and disorders of the nervous system. Through didactic coursework, laboratory research, career development training, and instruction in the responsible conduct of research, the students supported through this training mechanism will be poised to make important contributions to preventing and curing a spectrum of neurological and psychiatric disorders, such as autism, epilepsy, schizophrenia, dementias, communicative disorders, and addiction.

PI_NAMEs: MALKOVA, LUDISE  (contact);VANMETER, ASHLEY S

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Neurosciences;pre-doctoral;Training

PROJECT_TITLE: Predoctoral Training in Integrative Neuroscience

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (03)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: BIRMINGHAM

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Our goal is to renew the University of Alabama at Birmingham (UAB) Cancer Prevention and Control Training Program T32 training grant, the only one in the heart of the United States Deep South. We intend to train the next generation of cancer prevention and control scientists to conduct transdisciplinary research – an approach to creating new knowledge that builds upon standard team science approaches via exposure to new perspectives. Program components include high-quality mentorship by dual-mentor teams, experiential learning, and didactive courses that foster (a) knowledge acquisition regarding cancer prevention and control research, transdisciplinary research, and research ethics; and (b) professional, relational, and leadership skill development.

PI_NAMEs: ANEJA, RITU  (contact);NORIAN, LYSE A;SMITH, ELLEN MARY LAVOIE

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Cancer Control;cancer prevention;Training Programs

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative To help ensure that the nation’s biomedical, clinical, and behavioral cancer research workforce remains strong, we present our vision for the next 5 years of the Case CCC Cancer-focused Summer Undergraduate Research (CanSUR) Program. The objectives of the program are to recruit 32 highly motivated undergraduate students from diverse backgrounds each year and (1) provide them with a cancer research experience including project development, execution, interpretation, and reporting of research results; (2) educate them about available cancer research career opportunities; and (3) provide Cancer-Focused Career and Scientific Enrichment Curriculum to help prepare them for the next step in a cancer research/oncology-focused career.

PI_NAMEs: JACKSON, MARK W. (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Admission activity;Advocate;Affinity;anti-cancer research;Appointment;Area;Authorship;Behavioral;bench to bedside;Biomedical Research;Cancer Biology;Cancer Center;cancer education;cancer health disparity;cancer prevention;cancer therapy;career;Career Choice;Clinical;college;Committee Members;Communication;community building;Comprehensive Cancer Center;Core Facility;curriculum development;Development;disadvantaged background;Education;Educational Curriculum;Ensure;Evaluation;experience;Faculty;Fostering;Funding;Future;Goals;graduate school;graduate student;Habits;Health Professional;Immersion;Individual;Institution;Journals;Laboratories;Learning;Learning Module;learning strategy;lectures;Malignant Neoplasms;medical schools;meetings;member;Mentors;Mentorship;Minority Groups;Oncology;Outcome;Participant;Patients;peer;peer coaching;Persons;Population Research;Positioning Attribute;Postdoctoral Fellow;programs;Publications;Readiness;recruit;Reporting;Research;Research Ethics;Research Personnel;Research Project Grants;Research Technics;Safety;satisfaction;Scientist;skill acquisition;skills;social;Solid;Speed;Structure;student participation;success;summer program;summer research;symposium;Training;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;Underserved Population;Universities;university student;virtual reality;Vision;War;workforce needs;Writing


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Data Science;Neurosciences

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: NARRATIVE The mission of our Neuroscience Training Program is to create the preeminent neurophotonics training program that will produce the next-generation of investigators capable of rigorously and creatively developing and applying photonics methods across a wide array of neuroscience sub- fields to advance our understanding of the brain in health and disease. Our trainees will gain the foundational knowledge of the field that will permit them to continue to grow with the field and efficiently translate their breakthroughs from the academic lab to real world applications. In addition to building a field-defining neurophotonics curriculum, combining technical training, computational / data analysis, and critical thinking skills, we will provide robust training in the professional and operational skills required for success in this highly interdisciplinary field.

PI_NAMEs: BOAS, DAVID A (contact);CHEN, JERRY L;SANDER, MICHELLE YEN-LING

PROJECT_TITLE: Graduate Training at the Interface of Neuroscience, Optical Engineering and Data Science

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-R (15)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: TUCSON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE  This multidisciplinary training program is designed to train pre-doctoral students (6 per year) to investigate the underlying the roles of Infection and Inflammation as Drivers of Aging. Increased training in biomedical sciences pertinent to the biology of aging is critical to address the needs of the growing number of older adults, that will make over a quarter of the US population and ~1.5 billion people worldwide by 2050. Specific training in the roles of infection and inflammation as drivers of aging will help understand and treat sources of inflammation that propagate and aggravate many chronic diseases of old age, including arthritis, cancers, cardiovascular, metabolic and neurodegenerative diseases, like Alzheimer’s and Parkinsons.

PI_NAMEs: GOODRUM, FELICIA D;NIKOLICH, JANKO Z. (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: drivers of aging;Infection;Inflammation;pre-doctoral;Training Programs

PROJECT_TITLE: Infection and Inflammation as Drivers of Aging (IIDA) Predoctoral Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (J2)]


PHR: We aim to launch the Duke Psychiatry Physician Scientist Track Program (Duke-PPST) to train world-class psychiatrist-scientists by providing coordinated and sustained mentoring and research experiences. The Duke- PPST will address the critical workforce shortage of psychiatrist-scientists including those working in child psychiatry, an area of particular strength in our department. The Duke-PPST will also add needed geographic diversity to NIMH R25 programs (currently only 2 programs are in the South, despite the South comprising nearly 40% of the US population) and will enhance diversity among the psychiatrist-scientist workforce through recruitment and support of trainees under-represented in medicine.

PI_NAMEs: POSNER, JONATHAN E (contact);VESTAL, HEATHER S

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acceleration;Acute;Adolescent Psychiatry;Age;American;Appointment;Area;Biometry;Brain;Brain Diseases;BRAIN initiative;burden of illness;career;Child Psychiatry;Clinical;clinical training;Communities;COVID-19 pandemic;Dedications;Doctor of Philosophy;Education Projects;education research;Ensure;experience;Faculty;Financial Support;flexibility;Funding;Geography;Goals;Grant;Health Sciences;Historically Black Colleges and Universities;Home;Human;Human Subject Research;improved;innovation;Institution;Knowledge;Leadership;Life;Medical;medical schools;Medical Students;Medicine;Mental disorders;Mental Health;Mentors;Methods;National Institute of Mental Health;Neurosciences;next generation;North Carolina;Outcome;Pathway interactions;Physician Shortage Areas;Physicians;Play;Population;Positioning Attribute;Post Graduate Year;Prevalence;Program Evaluation;programs;Psychiatrist;Psychiatry;Publishing;Recording of previous events;recruit;Reporting;Research;research in practice;Research Personnel;Research Support;Research Training;Residencies;response;Role;Rotation;Schedule;Science;Scientist;Services;success;Supplementation;symposium;Talents;Therapeutic;Time;Training;Training and Infrastructure;Training Programs;Translating;Travel;United States National Institutes of Health;Universities;Wages;Work;Writing

PROJECT_TITLE: Duke University Psychiatry Physician-Scientist Residency Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (01)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Effective treatments of vision loss in 15 million Americans who live with impaired vision will require integration of basic, applied and clinical vision research. The goal of the T32 Vision Training program at the University of Utah is to equip new generations of predoctoral and postdoctoral students with multidisciplinary knowledge and practical expertise to achieve this.

PI_NAMEs: KRIZAJ, DAVID  (contact);VETTER, MONICA L

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TITLE: Vision Research Training Grant at the University of Utah

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (05)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Cancer

ORG_CITY: ROCHESTER

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Since 2004, the Clinical and Translational Cancer Control Research Training Program (CCRTP) has appointed 49 exceptional postdoctoral trainees including next years’ class (36 PhDs:13 MDs) to prepare them for independent careers in the multidisciplinary arena of cancer control research through research, didactic training, and professional development. By providing exceptional mentoring and a unique, state-of-the-art environment, the CCRTP prepares trainees to better understand the numerous debilitating side effects of cancer treatment, develop novel interventions, advance standards of care, and improve quality of life for patients with cancer, survivors, and their caregivers.

PI_NAMEs: JANELSINS, MICHELLE C (contact);MORROW, GARY R;PEPPONE, LUKE JOSEPH

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Cancer Control Research;Clinical;Training Programs


ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The population of older adults in the United States is expanding rapidly as is the understanding of the aging biology and engineering. In order to better train scientists to improve the health of older adults, clinical, biological, and engineering disciplines need to be brought together to solve problems and improve health of older adults. The purpose of this training program is to train postdoctoral fellows in translational aging research so that they can go on to become scientists focused on improving the health of older adults.

PI_NAMEs: ABADIR, PETER M.;WALSTON, JEREMY D (contact)

PROGRAM_OFFICER_NAME: DUTTA, CHHANDA

PROJECT_TITLE: Translational Aging Research Training Program


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative. The Harvard Therapeutics Graduate Program (TGP) will train PhD students for academic and industry careers in the discovery, evaluation, and safe clinical use of drugs. This interdisciplinary program will recruit students from multiple Harvard PhD programs to build a diverse and inclusive community focused on therapeutic science, with a strong emphasis on professional skills development and career mentoring in addition to rigorous science.

PI_NAMEs: GOLAN, DAVID E. (contact);MITCHISON, TIMOTHY J

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: pharmacologic;Science;Training

PROJECT_TITLE: Training in Pharmacological Sciences

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Data Science;Health Services;Urologic Diseases;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE The AUGS/DUKE UrogynCREST program will teach participants how to utilize large datasets to perform research that will improve the delivery of high-quality health care for patients with pelvic floor disorders and encourage reproducible research. By providing creative educational activities that focus on research skills development and bringing together expertise in health services research, biostatistics, decision science, and data science, the program will add structure to the health data science education for assistant professor level faculty in urogynecology. Overall, the program will shape future scientific leaders in urogynecology by encouraging the development of clinician-scientists and provide the skills and mentorship for invigorating data discovery and tools for investigations in health service research specifically addressing pelvic floor disorders.

PI_NAMEs: AMUNDSEN, CINDY  (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: Academia;Address;Age;Agreement;American;Area;Biometry;career;Clinical;clinical decision-making;Clinical Research;Code;cohort;Collaborations;Connective Tissue;Country;Creativeness;Data;Data Analyses;Data Discovery;data repository;Data Science;data science education;Data Set;data tools;Databases;Dedications;design;Development;E-learning;Education;education research;Educational Activities;Educational process of instructing;Environment;expectation;experience;Faculty;Fecal Incontinence;Fostering;Funding;Future;Goals;Grant;hands on research;Health;health care quality;health data;Health Services;Health Services Research;Healthcare;improved;Infrastructure;injured;innovation;Institution;Instruction;interest;Investigation;Journals;Knowledge;large datasets;Leadership;Learning;Manuscripts;meetings;Mentors;Mentorship;Metadata;Methodology;Methods;multidisciplinary;Muscle;next generation;Participant;Patient Care;Patient Recruitments;peer coaching;Peer Review;Pelvic Floor Disorders;pelvic organ prolapse;Pelvis;Persons;Play;professor;programs;protocol development;Public Health;Publications;racial diversity;recruit;repository;Reproducibility;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;responsible research conduct;Role;Science;Scientific Advances and Accomplishments;Scientist;Shapes;skill acquisition;skills;Societies;socioeconomics;Source;Specific qualifier value;stem;Structure;System;Teaching Method;tool;Training;Training Programs;Universities;Urinary Incontinence;virtual;Woman;Women's Health;women's treatment;Work

PROJECT_TITLE: UrogynCREST Program

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetic Testing;Genetics;Health Services;Human Genome

ORG_DEPT: GENETICS

PHR: Genetic counselors are vital to genomic medicine, but research questions in which they have key insights remain unanswered because most genetic counselors lack the practical experience, research methods expertise, and necessary research community to formulate, conduct, and lead large-scale research projects. PROMOTE-GC is designed to address these barriers by providing a part-time, 2-year research training experience for master’s-level genetic counselors that includes 1) mentored intensive research experiences, 2) training in research methods, and 3) support in building a durable, multidisciplinary professional research community they can call on in the future. This training benefits not only the individual genetic counselor participants, but also the genomic medicine enterprise by enhancing the research capacity of these vital members of the workforce.

PI_NAMEs: JAMES, CYNTHIA A;RASMUSSEN, SONJA ANN (contact)

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TERMS: Address;Area;Award;Bioethics;Businesses;career;Caring;cascade genetic testing;Clinical;clinical care;clinical investigation;Clinical Sciences;Collaborations;Communication;Communities;Counseling;course sequence;Data Analyses;design;disability;Discipline of Nursing;Doctor of Philosophy;early experience;Eligibility Determination;empowerment;Enrollment;ethical, legal, and social implication;experience;Family;flexibility;Foundations;Funding;Future;Genetic;Genetic Counseling;genetic counselor;genetic testing;Genome;Genomic medicine;Genomics;Goals;Grant;Individual;insight;interest;Interest Group;Journals;Lead;Leadership;Manuscripts;Medical;Medical Genetics;medical specialties;meetings;member;Mentors;Methods;multidisciplinary;National Human Genome Research Institute;Oral;outreach;Participant;Patients;Persons;Positioning Attribute;posters;Preparation;Professional Organizations;programs;Public Health Schools;Recommendation;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;Role;Scientist;Series;Site;skills;Students;summer institute;Supervision;symposium;Test Result;Time;Training;Training and Education;Training Programs;Travel;undergraduate student;United States National Institutes of Health;Universities;Vital capacity;webinar;Widespread Disease;Work

PROJECT_TITLE: Promoting Genetic Counselors in Independent Research Through Advanced Training and Education (PROMOTE-GC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-T (J1)]


NIH_SPENDING_CATS: Clinical Research;Mental Health

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE The objective of the Boston University Medical Campus-Massachusetts General Hospital Global Psychiatric Clinical Research Training Program (BUMC-MGH GPCRTP) is to develop independent clinical scientists who can address the most pressing global mental health challenges. The postdoctoral fellowship is a three-year clinical research training program that combines rigorous didactic instruction, clinical research methods training from Boston University and Harvard University, practice in working effectively with disadvantaged communities, and immersive, mentored research experiences in Barbados, Ethiopia, Peru, South Africa, Uganda and/or Ukraine.

PI_NAMEs: HENDERSON, DAVID C (contact);O'CLEIRIGH, CONALL MICHAEL

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Boston;Clinical Research;General Hospitals;Massachusetts;Medical;Training Programs;Universities

PROJECT_TITLE: Boston University Medical Campus- Massachusetts General Hospital Global Psychiatric Clinical Research Training Program


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The Martinos Center at MGH requires reinvestment in its Siemens Eclipse HP cyclotron infrastructure to ensure continued access to PET radioisotopes for its dynamic MR-PET imaging program. Instead of replacing the cyclotron, a series of upgrades will extend its lifespan by 10-15 years and support an extraordinarily strong and growing user community. This cost-effective plan will guarantee a reliable supply of radioisotopes and radiotracers for NIH-funded investigators' research and beyond.

PI_NAMEs: HOOKER, JACOB M. (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Applications Grants;Boston;Brain;Carbon;Clinical Trials;Communities;Computer software;Computers;Copper;cost effective;Cyclotrons;Development;Elements;Ensure;experimental study;Fluorine;Funding;General Hospitals;Heart Research;human imaging;human study;Image;imaging program;Infrastructure;innovation;instrument;Investments;Isotopes;life span;Magnetic Resonance;Maintenance;manufacture;Massachusetts;Medical;Minor;Modernization;nonhuman primate;Positron-Emission Tomography;preclinical study;Production;programs;Protocols documentation;Radiochemistry;Radioisotopes;radiotracer;Research;Research Personnel;Resource Sharing;Rodent;Scanning;Series;Services;Shipping;Solid;Source;System;United States National Institutes of Health;Vacuum

PROJECT_TITLE: Revitalization and upgrade of cyclotron

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-M (30)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Nashville

ORG_DEPT: NEUROLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE The prevalence of Alzheimer’s disease is rising dramatically as the population ages, with 13.8 million Americans expected to be affected by 2050. There is a pressing need to prepare basic and clinical scientists with cutting-edge, interdisciplinary research training to foster innovative research advances that address the complex, overlapping pathological processes underlying this growing public health issue.

PI_NAMEs: JEFFERSON, ANGELA L. (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Alzheimer's Disease;Training Programs

PROJECT_TITLE: Vanderbilt Interdisciplinary Training Program in Alzheimer's Disease


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The proposed training plan will educate early stage graduate students in the broad and interdisciplinary field of neuroscience. The program includes didactic coursework, training in critical thinking, experimental design and analysis, rigorous evaluation of laboratory research, and sustained experience in experimental science as well as training in personal and professional ethics, professional skill development, and career planning, all leading to a doctoral degree in neuroscience. Training takes place in an academic medical center environment with both fundamental basic research and translational and clinical research, allowing us to prepare trainees both intellectually and technically to become the next generation of neuroscientists, which is critical to the understanding and treatment of neuropsychiatric disorders.

PI_NAMEs: MONK, KELLY R (contact);WRIGHT, KEVIN

PROJECT_TITLE: Multidisciplinary Training in Neuroscience


PHR: PROJECT NARRATIVE Americans fear blindness more than virtually any other health problem. Approximately 14 million Americans, or approximately 6% of people aged 12 years and older, are visually-impaired. This will become an increasing clinical and public health problem as the population ages. Fundamental advances in science and technology have enormous promise for the treatment of eye disease. The premise of this proposal is to train the next generation of vision scientists in basic, clinical, and translational vision research to further our understanding of the underlying causes of ocular diseases and develop new clinical therapies for their treatment.

PI_NAMEs: JIA, YALI ;KELLER, KATE E (contact)

PROJECT_TITLE: Translational Vision Science Research at Oregon Health & Science University


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: FORT WORTH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

PHR: Narrative Training in the neurobiology of aging and Alzheimer's Disease is proposed to address the ever- increasing number of individuals in our society who have age-associated nervous system diseases and conditions, including Alzheimer's Disease. We propose to continue a successful interdisciplinary predoctoral training program that focuses on scientific excellence and leadership, diversity training, and preparation of trainees for successful careers in the neurobiology of aging and Alzheimer's Disease, through intensive research, research-related activities and publication of high-quality research reports.

PI_NAMEs: BARBER, ROBERT CLINTON;SUMIEN, NATHALIE  (contact)

PROJECT_TITLE: Training in the Neurobiology of Aging and Alzheimer's Disease


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE There is a shortage of qualified clinician-scientists, particularly in Radiology to support and/or advance imaging science to enable non-invasive quantitative biomarker analyses to fuel discoveries aimed at detecting, treating, monitoring disease response to therapy, or understanding human diseases. The UT Southwestern (UTSW) campus and the Department of Radiology specifically, have outstanding and extensive physical and human resources and many well-funded, well-known, and experienced mentors to attract, engage and train future clinician scientists in Radiology. We developed a novel training model that engages trainee physicians in research early and keeps them engaged throughout their tenure that was highly successful during the prior award which we are renewing with yet more improvements.

PI_NAMEs: MATTREY, ROBERT F (contact);PEDROSA, IVAN ;YOKOO, TAKESHI

PROGRAM_OFFICER_NAME: ERIM, ZEYNEP

PROJECT_TERMS: imaging scientist;Scientist;Training

PROJECT_TITLE: Training Clinician Scientists as Outstanding Clinicians and Imaging Scientists


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The Integrative Physiology of Aging T32 will train the next generation of MD and PhD scientists to better understand and study ways to keep people healthy as they age. The T32 stresses: 1) co-mentoring trainees by primary and associate mentors; 2) individualized career development plans; and 3) team science training.

PI_NAMEs: MOREAU, KERRIE  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Aging;Grant;Physiology;Training

PROJECT_TITLE: Integrative Physiology of Aging Training Grant


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: The Bloomington Drosophila Stock Center is the U.S. repository and distribution center for genetically characterized strains of Drosophila melanogaster, an insect used in thousands of laboratories worldwide both to investigate fundamental biological processes and to understand cellular mechanisms related to human diseases.

PI_NAMEs: COOK, KEVIN R (contact);KAUFMAN, THOMAS CHARLES;PARKS, ANNETTE L.;TENNESSEN, JASON MICHAEL;WHITWORTH, CALE ;ZHENG, XIANGZHONG

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Aging;base;Behavior;Biological;Biological Models;Biological Process;Brain;cell type;Cells;Cellular biology;Characteristics;Collection;Communities;Complex;Computers;Consultations;cost;Country;Custom;data management;Development;Discipline;Disease;Drosophila genus;Drosophila melanogaster;drug discovery;Eukaryota;Evolution;Experimental Genetics;Fees;fly;Funding;Future;Gene Expression;Genes;Genetic;genetic resource;genetic strain;Genetic study;genetic technology;Genome;Genotype;Goals;Grant;Health;Human;human disease;improved;Income;Indiana;Individual;Informatics;Information Management;Information Resources;Infrastructure;Insecta;International;Investigation;Investments;Laboratories;Maintenance;Management Information Systems;medical specialties;Metabolism;Methodology;model organism;Modeling;Molecular;Nerve;Neurobiology;Neurons;operation;Organism;Pathology;Pattern;Physiological;Physiology;Population Biology;preservation;Process;Productivity;programs;Recovery;Reporter Genes;Reporting;repository;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resource Development;Resources;Role;Sampling;Scientist;screening;Secure;Services;Source;success;Technology;Tissues;tool;Training;Transgenes;trend;United States National Institutes of Health;Universities;web site;Work

PROJECT_TITLE: Bloomington Drosophila Stock Center at Indiana University

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-J (55)]


NIH_SPENDING_CATS: Genetics;Neurosciences

PI_NAMEs: WHITWORTH, CALE  (contact)

PROJECT_TERMS: Aging;base;Behavior;Biological;Biological Models;Biological Process;Brain;cell type;Cells;Cellular biology;Characteristics;Collection;Communities;Complex;Computers;Consultations;cost;Country;Custom;data management;Development;Discipline;Disease;Drosophila genus;Drosophila melanogaster;drug discovery;Eukaryota;Evolution;Experimental Genetics;Fees;fly;Funding;Future;Gene Expression;Genes;Genetic;genetic resource;genetic strain;Genetic study;genetic technology;Genome;Genotype;Goals;Grant;Health;Human;human disease;improved;Income;Indiana;Individual;Informatics;Information Management;Information Resources;Infrastructure;Insecta;International;Investigation;Investments;Maintenance;Management Information Systems;medical specialties;Metabolism;Methodology;model organism;Modeling;Molecular;Nerve;Neurobiology;Neurons;operation;Organism;Pathology;Pattern;Physiological;Physiology;Population Biology;preservation;Process;Productivity;programs;Recovery;Reporter Genes;Reporting;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resource Development;Resources;Role;Sampling;Scientist;screening;Secure;Services;Source;success;Technology;Tissues;tool;Training;Transgenes;trend;United States National Institutes of Health;Universities;web site;Work

PROJECT_TITLE: Resource Component: Acquisition, maintenance and distribution of Drosophila stocks


PI_NAMEs: PARKS, ANNETTE L. (contact)

PROJECT_TITLE: Curation and Informatics Component: Improving data management infrastructure


PI_NAMEs: COOK, KEVIN R (contact)

PROJECT_TERMS: Aging;Applied Research;base;Behavior;Biological;Biological Models;Biological Process;Brain;cell type;Cells;Cellular biology;Characteristics;Collection;Communities;Complex;Computers;Consultations;cost;Country;Custom;data management;Development;Discipline;Disease;Drosophila genus;Drosophila melanogaster;drug discovery;Eukaryota;Evolution;Experimental Genetics;Fees;fly;Funding;Future;Gene Expression;Genes;Genetic;genetic resource;genetic strain;Genetic study;genetic technology;Genome;Genotype;Goals;Grant;Health;Human;human disease;improved;Income;Indiana;Individual;Informatics;Information Management;Information Resources;Infrastructure;Insecta;International;Investigation;Investments;Maintenance;Management Information Systems;medical specialties;Metabolism;Methodology;model organism;Modeling;Molecular;Nerve;Neurobiology;Neurons;operation;Organism;Pathology;Pattern;Physiological;Physiology;Population Biology;preservation;Process;Productivity;programs;Recovery;Reporter Genes;Reporting;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resource Development;Resources;Role;Sampling;Scientist;screening;Secure;Services;Source;success;Technology;Tissues;tool;Training;Transgenes;trend;United States National Institutes of Health;Universities;web site;Work

PROJECT_TITLE: Applied Research Component: Improving genetic resources available to the research community


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project narrative This multidisciplinary five-year education program is designed to provide opportunities of early research exposure for high-school students, with the focus on promoting neuroimaging and data science technologies for AD/ADRD research. The program includes a set of asynchronous/synchronous short courses, hands-on practice, mentored research, scientific development activities, and a cloud-based computational platform for analyzing neuroimaging data. The expected outcome is to attract high-school students in AD/ADRD research and train next-generation investigators with computational skill-sets for solving real-world healthcare problems in AD/ADRD.

PI_NAMEs: KAUR, JASLEEN ;KIM, MINJEONG ;WU, GUORONG  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease related dementia;biomedical imaging;Biometry;Brain;career;clinical application;cloud based;Collection;computational platform;computer science;computerized tools;connectome;Consensus;Cultural Backgrounds;Data;Data Analyses;Data Collection;data management;Data Science;Data Scientist;design;Development;Disease;Disease Progression;Ecosystem;Education;Education Projects;education research;Educational Curriculum;empowerment;Engineering;Environment;experience;Exposure to;Faculty;Fostering;Foundations;Funding;Future;Goals;hands on research;Healthcare;High School Outreach;High School Student;Hybrids;Image;Image Analysis;image processing;imaging study;in vivo;Industrialization;interest;Joints;lectures;Machine Learning;Magnetic Resonance Imaging;Mathematics;member;Mental Health;Mentors;Mentorship;morphometry;multidisciplinary;neuroimaging;neuroimaging marker;Neurology;next generation;North Carolina;Outcome;outreach;Outreach Research;Pathology;Performance;personalized medicine;Physics;Positron-Emission Tomography;programs;prospective;Psychiatry;Radiology Specialty;Reproducibility;Research;Research Ethics;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;response;Schools;Science;Science, Technology, Engineering and Mathematics;science, technology, engineering, mathematics, and medicine;Scientist;Series;skills;Standardization;Statistical Data Interpretation;STEM program;student participation;Student recruitment;student training;Students;success;summer program;summer research;Technology;tool;Training;Training Programs;Translating;treatment strategy;Underrepresented Populations;United States National Institutes of Health;Universities;Visualization;Work;World Health

PROJECT_TITLE: Summer Research Education Program for Promoting Computational Neuroimaging Technology in Alzheimer's Disease (AD) and AD-Related Dementias (ADRD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-D (J1)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome

ORG_CITY: HUNTINGDON

ORG_NAME: JUNIATA COLLEGE

ORG_STATE: PA

PHR: Project Narrative This study will introduce a paradigm shift in how the microbiome alterations characterizing C. difficile infection (CDI) are viewed, one that would be highly clinically relevant toward improving our knowledge, and potentially our treatment, of a disease responsible for over 1.5 billion dollars in annual healthcare costs in the United States. The data from this project will help establish the role of fungi in CDI, especially C. glabrata; the role of fungi could help to explain the persistently elevated rate of treatment failures observed in current CDI therapy. The results of this project will broaden the scientific community’s understanding of the pathogenesis of CDI, while furthering work by Dr. Lamendella’s team, suggesting that fungi may be a therapeutic target in treating CDI.

PI_NAMEs: LAMENDELLA, REGINA   (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Accounting;Affect;Age;animal data;Anti-Bacterial Agents;anti-fungal agents;Antibiotic Therapy;Antibiotics;Bacteria;Bacterial Infections;Big Data;biobank;Bioinformatics;Biological;Biological Markers;Biomedical Research;Candida albicans;Candida glabrata;Chronic;Clinical;clinically relevant;Clostridium difficile;cohort;Collaborations;Communities;comorbidity;complex biological systems;computerized tools;Country;Data;Development;Diarrhea;differential expression;Disease;DNA;Enterococcus;Environment;Exhibits;experience;FDA approved;Feces;Fostering;Funding;Funding Mechanisms;Fungal Components;fungus;Future;Gastrointestinal tract structure;Gender;Genes;Genome;genome-wide;Genomics;Goals;Growth;Health Care Costs;Health Expenditures;Human;Immune response;Immunologic Markers;Immunologics;immunoregulation;improved;Individual;Infection;Knowledge;Lead;Link;Machine Learning;machine learning model;Maps;member;Metabolic;Metabolic Pathway;metabolomics;Metadata;Metagenomics;metatranscriptomics;microbial;Microbial Biofilms;microbial genome;microbiome alteration;microbiome research;Modeling;multiple omics;Mus;neural network;Nosocomial Infections;novel;Nutrient;Outcome;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;potential biomarker;Prevalence;programs;Publishing;quorum sensing;recruit;Recurrence;Relapse;Research;Research Personnel;Resources;RNA;Role;Scientist;Severities;Severity of illness;Signal Pathway;skills;stool sample;Students;Taxonomy;Technology;therapeutic target;tool;Treatment Failure;Treatment outcome;Underrepresented Students;United States;University Hospitals;Validation;Visualization;Work

PROJECT_TITLE: Multi-omics integration to model the differential metabolic activities of Candida glabrata and bacteria in humans with C. difficile infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 MMO-D (J1)]


ORG_NAME: HOWARD UNIVERSITY

PHR: Project Narrative Howard University is a research-active Historically Black University that is uniquely positioned to recruit a strong cadre of talented recent baccalaureate graduates and train them for research- focus careers in Alzheimer’s Disease and Related Dementias (ADRD). We propose the development of the HU-ERA program to significantly address the deficit in the number of Black and African Americans in ADRD-focused PhD or MD/PhD programs or ADRD-research industry positions. Selected trainees will be provided with intensive, mentored research experiences, professional development, and career building activities to expand skills and expertise relevant to ADRD-focused biomedical research.

PI_NAMEs: ALLARD, JOANNE S (contact);DUTTAROY, ATANU ;SHARMA, SUDHA

PROJECT_TERMS: Academic Medical Centers;Achievement;Address;Admission activity;Affect;African American;African American population;age related;age-related disease;Aging;aging brain;aging population;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;American;Biomedical Research;biomedical scientist;Black American;career;Clinic;Clinical Investigator;cohort;Communication;Critical Thinking;Data Analyses;Dedications;Degenerative Disorder;Degree program;Dementia;design;Development;Discipline;Disease;Doctor of Philosophy;education research;education resources;Educational Activities;Educational workshop;Elderly;Elements;Environment;equity, diversity, and inclusion;Ethics;experience;Faculty;forging;Fostering;Funding;graduate school;Growth and Development function;Health;Historically Black Colleges and Universities;human old age (65+);human very old age (85+);Individual;Industry;insight;Institution;Interdisciplinary Study;interest;International;Interview;Laboratories;Leadership;Longevity;matriculation;Measures;Medical;Mentors;Mentorship;minority communities;Mission;Monitor;Neurosciences Research;Occupations;Pathway interactions;Population;Positioning Attribute;Postbaccalaureate;Prevalence;Private Sector;Program Effectiveness;programs;Qualifying;Race;racial diversity;Records;recruit;Reproducibility;Research;Research Personnel;Research Training;responsible research conduct;Science;Scientist;Secure;Self Efficacy;Series;skills;success;symposium;Talents;Therapeutic;therapeutic development;Time;Training;Training Activity;Training and Education;Training Programs;undergraduate student;Underrepresented Minority;Universities;virtual;Work

PROJECT_TITLE: The Howard University Expanding Research in Alzheimer's Disease and Related Dementias  Postbaccalaureate Research Education Program (HU-ERA-PREP)


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The proposed studies are aimed at determining how neurons in the external globus pallidus and their synaptic targets control motor output. By surveying cellular, circuit, and behavioral alterations in an animal model of Parkinson’s disease, our goal is to provide a framework for new and improved therapeutic strategies.

PI_NAMEs: CHAN, SAVIO  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Adult;Animal Model;Axon;Basal Ganglia;Behavioral;Calcium-Binding Proteins;cell type;Cells;Chronic;Corpus striatum structure;Disease;Dopamine;dopaminergic neuron;Dorsal;Electrophysiology (science);Elements;experimental study;FOXP2 gene;Functional disorder;Funding;Genetic;Globus Pallidus;Goals;improved;in vivo;insight;Intervention;Investigation;Knowledge;Lesion;Modeling;Molecular;Monitor;Motor;Motor Activity;motor behavior;motor control;Motor Neurons;Motor output;Movement;Mus;neural;neuronal cell body;Neurons;Optics;optogenetics;Oxidopamine;Parkinson Disease;Parvalbumins;patch clamp;Pathway interactions;Pattern;Play;Process;Property;Regulation;Reporter;Research;Role;Series;Shapes;Signal Transduction;Site;Speed;statistics;Substantia nigra structure;Surveys;Symptoms;Synapses;Taxonomy;Testing;Therapeutic;Time;tool;transcription factor;Translations

PROJECT_TITLE: Investigation of Pallidal Neurons in Motor Inhibition

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Natural products are both an essential source of novel drugs and widely used by the U.S. public as dietary supplements in and for self-medication. This training program will continue to support the education of the next generation of scientists with the knowledge and skills to discover new therapeutic agents and be responsible for establishing the safety and efficacy of health products from natural sources.

PI_NAMEs: ORJALA, JIMMY ;PAULI, GUIDO F (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Complementary Health;Integrative Medicine;Natural Products;Research Training

PROJECT_TITLE: Research Training in Natural Product Complementary and Integrative Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (03)]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: LAS VEGAS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: Project Narrative Esophageal squamous cell carcinoma (ESCC) is the deadliest of all human squamous cell carcinomas, and has a relatively low five-year survival rate. Abnormalities in stress response signaling and epithelial to mesenchymal transition (EMT) have gained prominence as cancer promoting mechanisms. These studies will define whether radiation-induced persistent pATF2 stress response signaling, is a key node in promoting EMT and changes in the microenvironment that facilitate radiation-induced ESCC initiation and/or progression.

PI_NAMEs: PLUTH, JANICE M (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: 3-Dimensional;Acute;Address;Affect;Architecture;Area;ATF2 gene;Biological;Biological Assay;Biological Markers;biomarker identification;cancer cell;cancer risk;cancer therapy;carcinogenesis;Cell Culture System;Cell Survival;cell transformation;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Data;Dependence;Detection;DNA Repair Pathway;Dose;early detection biomarkers;Early identification;Environment;Epidermal Growth Factor Receptor;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Esophageal Adenocarcinoma;esophageal carcinogenesis;Esophageal Squamous Cell Carcinoma;Esophagus;Event;Exposure to;Fibroblasts;fractionated radiation;Fractionation;Gene Expression Profiling;Growth;Homeostasis;Human;human tissue;Hypoxia;Immunofluorescence Immunologic;Immunohistochemistry;improved;in vivo;Inflammation;innovation;insight;intercellular communication;Invaded;Kinetics;Knowledge;Link;Malignant - descriptor;Malignant neoplasm of esophagus;Malignant Neoplasms;Mediating;Mesenchymal;Modeling;Modification;Molecular;Morphology;Mutate;Mutation;neoplastic cell;Neoplastic Epithelial Cell;Normal Cell;Oncogenes;Organoids;Oxidative Stress;Pathway interactions;patient stratification;Patient-Focused Outcomes;Patients;permissiveness;Phenotype;Phosphorylation;Physiological;Predisposition;premalignant;Proliferating;Proteins;Radiation;radiation effect;Radiation exposure;Radiation therapy;Radiation-Induced Change;Recording of previous events;Regimen;Resistance;Risk;Risk Reduction;Role;senescence;Signal Transduction;Site;Squamous cell carcinoma;Stains;Stress;Stress Response Signaling;stressor;Survival Rate;System;Testing;Therapeutic;three dimensional cell culture;three-dimensional modeling;Tissue Differentiation;Tissue Engineering;Tissue Model;Tissue Stains;Tissues;transcription factor;Transcriptional Activation;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;Transforming Growth Factors;Translating;treatment response;tumor;tumor initiation;tumor progression;Untranslated RNA;Vimentin;Work

PROJECT_TITLE: Mechanistic understanding of role of ATF2 signaling in radiation-induced esophageal cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-X (SU)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Data Science;Mental Health

ORG_CITY: NEW YORK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative: Mental health disorders are a major cause of disability that significantly reduces the quality of life. As new technologies emerge for assessing mental health disorders and as research design becomes increasingly complex, the Department of Biostatistics at Columbia University, in partnership with Columbia’s Department of Psychiatry and New York State Psychiatric Institute, has developed an innovative program to train predoctoral scholars in biostatistical methods, machine learning, data science, and interdisciplinary research in order to meet the emerging challenges brought by cutting edge technologies and big data. The program will build on the Department’s strengths and decades of success in rigorous training of biostatisticians to prepare trainees as next-generation leaders in mental health biostatistics and data science (MH-BDS).

PI_NAMEs: OGDEN, TODD ;WANG, YUANJIA  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Biometry;Data Science;Mental Health;Research Training;Training Programs

PROJECT_TITLE: Research Training Program in Mental Health Biostatistics and Data Science

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (01)]


NIH_SPENDING_CATS: Bioengineering;Social Determinants of Health

ORG_CITY: PENSACOLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WEST FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Health concerns of the 21st century necessitate collaborative research efforts of an intelligent and skilled workforce. The diversity of professional research scientists can only result when all intelligent students are given the opportunity to ascertain their potential. The University of West Florida NIH URISE Scholars program will provide training opportunities and financial, academic, social, and professional support critical to recruitment and retention of students from underrepresented and disadvantaged backgrounds. These efforts are necessary to broadening and diversifying the pipeline of talented biomedical students to ensure.

PI_NAMEs: CAVNAR, PETER J.;JANOSIK, ALEXIS ;MOLEK, KAREN SINCLAIR (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: academic preparation;Biology;career;CCL7 gene;Chemistry;Development;Development Plans;disabled students;Doctor of Philosophy;Educational workshop;Emotional;Engineering;Enrollment;ethnic minority;Ethnic Origin;experience;Florida;Funding;graduate school;Individual;Institution;Life;living-learning community;matriculation;Mechanics;Mentors;Modeling;Names;Nature;physical conditioning;Physics;Preparation;programs;racial minority;Reproducibility;Research;resilience;Resources;Scholars Program;Series;social integration;socioeconomics;Students;Support System;Training;Underrepresented Students;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: U-RISE at the University of West Florida

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: OVERALL: NARRATIVE Diffuse large B-cell lymphoma (DLBCL) is an aggressive and clinically heterogeneous malignancy derived from germinal center (GC) B-cells. The central hypothesis of this P01 program is that different scenarios of aberrant GC immune synapse signaling to chromatin is the primary driver of these diverse DLBCL phenotypes and explains the divide between GCB and ABC DLBCLs. The various projects will synergistically probe this question from different perspectives, using innovative and cutting-edge technologies developed by the scientific cores, expecting to yield fundamental new insights into DLBCL pathogenesis and precision therapies.

PI_NAMEs: CERCHIETTI, LEANDRO C (contact);FLOWERS, CHRISTOPHER R

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Address;Age;age effect;Aging;aging process;B-Lymphocytes;Basic Science;biological heterogeneity;Biological Models;Biology;Biometry;Cell Fate Control;Cells;Chromatin;Chromatin Remodeling Factor;Classification;Clinical;Clinical Sciences;Communities;Complex;computational pipelines;Data;Data Analyses;Data Set;Databases;Development;Disease;disease phenotype;Epigenetic Process;epigenome;Etiology;Genetic;Genetic Transcription;Genetically Engineered Mouse;Genomics;Goals;graphical user interface;Image;Immune;immunological synapse;Immunologics;Immunotherapy;Informatics;innovation;insight;Integration Host Factors;large cell Diffuse non-Hodgkin's lymphoma;Lesion;Life Expectancy;Link;Lymphoma;Lymphoma cell;Lymphomagenesis;Malignant - descriptor;Malignant Neoplasms;malignant state;Mediating;Mediator;Methods;Modeling;molecular subtypes;Mutation;Nature;Pathogenesis;Pathology;Pathway interactions;Phenotype;Phosphotransferases;Physiological;Population;Precision therapeutics;Process;Program Research Project Grants;programs;Reaction;repository;Resources;Shapes;Signal Induction;Signal Transduction;Somatic Mutation;Structure of germinal center of lymph node;Systems Biology;targeted treatment;Technology;Therapeutic;Therapeutic Intervention;therapeutic target;Thinking;transcription factor;Translating;Translational Research;tumor;tumor eradication;tumor-immune system interactions;Work

PROJECT_TITLE: Epigenetic basis and therapeutic targeting of the unique lymphoma immunological niche

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-H (J1)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PHR: CORE A_ADMINISTRATIVE CORE: NARRATIVE The overall goal of the Administrative Core (Core A) is to assure the successful oversight and coordination of all Projects and Cores of the P01 Program, through expert guidance in fiscal management, centralized communication, and general administration for all activities.

PI_NAMEs: CERCHIETTI, LEANDRO C (contact)

PROJECT_TERMS: Affect;Award;Biological Models;Biometry;Biostatistics Core;Cancer Center Support Grant;Collaborations;Committee Members;Communication;Communication Research;Computational Biology;conflict resolution;data management;Development;Educational workshop;Ensure;Epigenetic Process;epigenomics;Evaluation;Event;Flowers;Funding;Genomics;Goals;Grant;Hematologic Neoplasms;Human Resources;Image;immunological synapse;Immunologics;Institution;Lead;Leadership;lectures;Lymphoma;Malignant Neoplasms;meetings;member;Monitor;Multiple Myeloma;National Cancer Institute;Notification;novel;Participant;Pathology;Program Research Project Grants;programs;Publications;recruit;Regulation;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Schedule;Services;Side;Strategic Planning;success;symposium;therapeutic target;Training;Translational Research

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PHR: PROJECT 1: NARRATIVE This proposal explores how somatic mutations in chromatin modifier genes synergize to alter the epigenetic and 3D genomic landscapes of B-cells to drive formation of profoundly immune-evasive lymphomas. Specifically, the investigators will identify the basic mechanism through which the common CREBBP and KMT2D enhancer regulatory proteins synergize to drive lymphomagenesis and engage in aberrant cross-talk with T-cell subpopulations. Based on their mechanistic discoveries they will develop novel therapeutic regimens aimed at restoring the functionality of the immune system and making these tumors vulnerable to immune eradication.

PI_NAMEs: MELNICK, ARI M. (contact)

PROJECT_TERMS: 3-Dimensional;Acetylation;Acute Myelocytic Leukemia;Affect;Architecture;B-Cell Lymphomas;B-Lymphocytes;BCL6 gene;Biochemical;Cells;Chromatin;Chromatin Remodeling Factor;Clone Cells;Combination immunotherapy;Complex;Coupled;CREBBP gene;cytotoxic CD8 T cells;Data;Development;Enhancers;Environment;Epigenetic Process;epigenetic therapy;epigenome;Follicular Lymphoma;functional restoration;Genes;Genetic;genetic regulatory protein;Genomics;Helper-Inducer T-Lymphocyte;Histocompatibility Antigens Class II;histone acetyltransferase;histone methyltransferase;Histones;Immune;immune checkpoint blockade;Immune Evasion;Immune system;Immunologic Surveillance;immunological synapse;Immunologics;Immunosuppression;Immunotherapy;Impairment;large cell Diffuse non-Hodgkin's lymphoma;Lead;Link;Literature;loss of function mutation;Lymphoma;Lymphomagenesis;Malignant - descriptor;Mediating;Missense Mutation;mutant;Mutation;Nonsense Mutation;novel;novel therapeutics;Oncogenes;Outcome;overexpression;Patients;Phenotype;Precision therapeutics;prevent;programmed cell death protein 1;programs;Proteins;rational design;Reaction;receptor;Receptor Signaling;recruit;Regimen;Regulator Genes;Repression;Research Personnel;response;Series;Signal Transduction;Somatic Mutation;Structure of germinal center of lymph node;Synapses;synergism;T-Lymphocyte;Therapeutic;therapeutic target;TNFRSF5 gene;tumor;Tumor Biology;tumor eradication;Tumor Escape;Tumor Promotion;Tumor Suppressor Proteins;tumor-immune system interactions;Work

PROJECT_TITLE: Project 1 Melnick


PHR: PROJECT 2: NARRATIVE In lymphoma signals that rapidly transmit information from the extracellular environment to alter gene expression and cell programming are aberrantly active resulting in a persistent growth and differentiation program. We study these signals and their function in lymphoma with the hypothesis that aggressive and difficult to treat lymphoma are highly dependent on them.

PI_NAMEs: JOSEFOWICZ, STEVEN ZVI (contact)

PROJECT_TERMS: activated B cell like;aged;Autoimmune;Automobile Driving;B-Cell Antigen Receptor;B-Lymphocytes;Biochemical;cell transformation;Cells;Centrocyte;Characteristics;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;CREBBP gene;Data;defined contribution;Dependence;derepression;Development;Differentiation and Growth;Environment;Epigenetic Process;Epstein Barr Virus B cell lymphoma;Epstein-Barr Virus-Related Lymphoma;Event;extracellular;Gene Expression;Genes;genetic signature;Genetic Transcription;Goals;Growth;Histone H3;Histones;Human;Human Herpesvirus 4;human model;immunological synapse;Immunologics;Inflammatory;knock-down;large cell Diffuse non-Hodgkin's lymphoma;Lymphoma;Lymphoma cell;Lymphomagenesis;Maintenance;Malignant - descriptor;MAP Kinase Gene;Memory B-Lymphocyte;Modeling;Molecular;mouse model;Mus;Mutagenesis;mutant;Mutation;NF-kappa B;novel;Oncoproteins;patient derived xenograft model;Patients;Phenotype;Phosphorylation;Phosphotransferases;Plasma Cells;programs;Protamine Kinase;recruit;Resistance;response;Rest;scaffold;Shapes;Signal Induction;Signal Pathway;Signal Transduction;small molecule inhibitor;Structure of germinal center of lymph node;System;T-Lymphocyte;Testing;therapeutic target;Toll-like receptors;transmission process;tumor;Viral;Viral Oncogene

PROJECT_TITLE: Project 2 Josefowicz


NIH_SPENDING_CATS: Aging;Cancer;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PHR: PROJECT NARRATIVE The purpose of our studies is to understand if a common type of aggressive lymphoma (diffuse large B-cell lymphoma) represents a biologically distinct entity when arises in elderly people. We will study epigenetic mechanisms associated with aging in favoring the activity of oncogenes and how this process may represent unique therapeutic vulnerabilities. If successful, these studies will launch the development of specific and likely low-toxicity treatments that could benefit elderly patients with incurable lymphomas.

PROJECT_TERMS: Accounting;activated B cell like;Affect;Age;age related;aged;Aging;Architecture;Attenuated;Automobile Driving;B-Lymphocytes;Biological;Biological Assay;Biology;cell community;Cells;Characteristics;chemotherapy;Chromatin;clinically relevant;cohort;combinatorial;comparative;Complex;Data;design;Development;Diagnosis;Disease;DNA Methylation;DNA Modification Process;Dose;Elderly;Enhancers;Epigenetic Process;Event;Extracellular Matrix;Fibroblasts;Gene Expression;Growth;healthy aging;Helper-Inducer T-Lymphocyte;Hematopoietic;Histones;Immune;immune cell infiltrate;Immune signaling;Immuno-Chemotherapy;immunological synapse;Immunologics;Impairment;improved;In Vitro;in vivo;individualized medicine;Inflammaging;Inflammatory;Inflammatory Infiltrate;Integration Host Factors;Intrinsic factor;large cell Diffuse non-Hodgkin's lymphoma;Lymphoma;Lymphoma cell;Lymphomagenesis;Malignant - descriptor;Malignant Neoplasms;Modeling;Molecular;Mus;Mutation;NF-kappa B;novel;novel therapeutic intervention;old mice;older patient;Older Population;Oncogenes;Oncogenic;Outcome;Pathologic;Pathology;Pathway interactions;Patients;Pattern;permissiveness;Persons;pharmacologic;Phenotype;Physiological;Physiology;Post-Translational Protein Processing;pre-clinical;Predisposition;Process;Prognosis;programs;Proliferating;promoter;rational design;Reaction;Regimen;Resistance;response;Role;Signal Transduction;Soil;Stimulus;Stromal Cells;Structure of germinal center of lymph node;Subgroup;System;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic target;Tissues;Toxic effect;Transcription Alteration;Treatment-related toxicity;tumor-immune system interactions;tumorigenesis;Work

PROJECT_TITLE: Project 3 Cerchietti


PHR: PROJECT 4: NARRATIVE The activated B-cell-like subtype of diffuse large B-cell lymphoma (ABC-DLBCL) is driven by chronic active B- cell receptor (BCR) signaling and constitutive NFκB activity. Here we aim to characterize the role of BCR and NFκB signaling in molding the epigenetic landscape of ABC DLBCL through transcription factors that recruit the histone acetyltransferase CREBBP. We will investigate the role of CREBBP in maintaining the expression of BCR and NFκB signaling genes, which may establish selective CREBBP inhibition as an attractive therapeutic strategy in ABC DLBCL.

PI_NAMEs: GREEN, MICHAEL RICHARD (contact)

PROJECT_TERMS: Acetyltransferase;activated B cell like;Affinity;aged;antagonist;Autoimmune;Automobile Driving;autoreactive B cell;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;BCL6 gene;Biological Models;Biology;Cell Line;Cells;Cellular biology;Centrocyte;Chemicals;Chromatin;Chronic;Classification;Cleavage Under Targets and Release Using Nuclease;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CREBBP gene;Engineering;Enhancers;EP300 gene;Epigenetic Process;epigenomics;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Enhancer Element;genetic signature;Genetic Transcription;Genetically Engineered Mouse;Histone Acetylation;histone acetyltransferase;Histone H3;Histones;Immunologics;inducible gene expression;inhibitor;IRF4 gene;large cell Diffuse non-Hodgkin's lymphoma;Light;Link;loss of function mutation;Lymphoma;Lymphomagenesis;Lysine;Mediating;Mediator;Memory;Modeling;Molds;molecular marker;mouse model;Mutant Strains Mice;Mutate;Mutation;Oncogenes;Outcome;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Phosphorylation;Physiological;Plasmablast;precision medicine;prevent;Process;Prognosis;programs;Proteins;Reaction;receptor;Receptor Signaling;recruit;Recurrence;RELA gene;Repression;response;rituximab;Role;Signal Pathway;Signal Transduction;Signaling Protein;Structure of germinal center of lymph node;Surface;Testing;Therapeutic;therapeutic target;TNFRSF5 gene;tositumomab;Transcription Coactivator;transcription factor;Transcriptional Activation;tumor;Tumor Suppressor Proteins

PROJECT_TITLE: Project 4 Green-Davis


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PHR: CORE 1 LYMPHOMA MODEL SYSTEMS: NARRATIVE The preclinical models and therapeutics core (LMSC) scope is relevant to public health because it provides an effective strategy for developing cancer models for comprehensive tumor profiling. These resources will enable project leaders to define selected lesions' pathogenetic role and identify their relevance in mouse and human tissue samples using engineered mouse models and PDX and PDO models. The construction of innovative platforms will provide new tools to cross-validate experimental findings, dissect the molecular culprits, and discover novel therapeutic avenues. The proposed research is relevant to the NCI’s mission to conduct and fund research in cancer.

PI_NAMEs: INGHIRAMI, GIORGIO  (contact)

PROJECT_TERMS: 3-Dimensional;Allogenic;Animals;Antibodies;Autologous;Automobile Driving;B-Lymphocytes;Biological;Biological Assay;Biological Models;cancer cell;Cancer Model;CD34 gene;Cell Line;Cell model;Cells;Chromatin;Clinic;Clinical;Collaborations;Complex;Data;Databases;Defect;Derivation procedure;design;Dissection;drug testing;Elements;Engineering;EP300 gene;Epigenetic Process;epigenome;established cell line;Evolution;Fingerprint;Fostering;Funding;Gene Expression;Gene Expression Regulation;Generations;Genetic;Genetic Transcription;Genetically Engineered Mouse;Genome;Genomics;Human;human tissue;humanized mouse;Immune;immunodeficiency;Immunologics;Impairment;In Vitro;in vitro activity;in vivo;in vivo Model;innovation;Intervention;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;lentiviral-mediated;Lesion;Libraries;Lymphocyte;Lymphoid;Lymphoma;Maintenance;Malignant Neoplasms;Mission;Modality;Modeling;Molecular;Morphology;mouse model;Mus;Neoplasms;novel;novel strategies;novel therapeutics;Older Population;Oncogenic;Organoids;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pre-Clinical Model;preclinical evaluation;Preclinical Testing;Prediction of Response to Therapy;predictive marker;Preparation;Primary Neoplasm;programs;Public Health;Reagent;Research;Research Personnel;Resources;Role;Sampling;Services;System;targeted treatment;Testing;Therapeutic;Therapeutic Studies;therapeutic target;three dimensional cell culture;tissue resource;Tissue Sample;Tissues;tool;transcriptome sequencing;Transgenic Organisms;Translating;translational cancer research;Treatment Protocols;treatment response;tumor;tumor heterogeneity;tumor xenograft;Validation;web site;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Core 1: Lymphoma models


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Rare Diseases

PHR: CORE 2_ BIOSTATISTICS AND COMPUTATIONAL BIOLOGY: NARRATIVE The Biostatistics and Computational Biology (BCB) Core for this P01 will enable cost-effective data processing, analysis, and contextualization of the omics data generated for all Projects and ensure rapid dissemination and easy access of these data.

PI_NAMEs: MASON, CHRISTOPHER EDWARD (contact)

PROJECT_TERMS: Algorithms;bioinformatics resource;Biological Assay;Biological Models;biomarker discovery;Biometry;Cancer Center;cancer genomics;Cancer Personalized Profiling by Deep Sequencing;Cells;ChIP-seq;Cleavage Under Targets and Release Using Nuclease;Clinical;Clonality;Complex;complex data;Computational Biology;computational suite;computerized data processing;computerized tools;computing resources;cost effective;Custom;Data;data access;Data Analyses;data integration;Data Set;data sharing;database of Genotypes and Phenotypes;deep learning;design;Digital Imaging and Communications in Medicine;Ensure;Environment;Epigenetic Process;epigenome;epigenomics;experience;experimental study;Faculty;Genetic;Genetic Transcription;genome sequencing;genomic data;Genomics;Genus Mentha;graphical user interface;Health Insurance Portability and Accountability Act;Hematopoietic Neoplasms;Hi-C;high throughput analysis;Human;Image;Immunologics;Infrastructure;Institution;large cell Diffuse non-Hodgkin's lymphoma;Learning;Libraries;Lymphoma;machine learning method;Manuscripts;Maps;Measures;Medicine;metabolomics;Methamphetamine;Methods;Modeling;mouse model;multimodal data;Multiomic Data;multiple omics;Mus;nanopore;next generation sequencing;novel marker;open source;Organoids;Pathology;Patients;Preparation;Process;Production;Program Research Project Grants;Publishing;Quality Control;Reporting;repository;Reproducibility;Research;Research Personnel;Research Project Grants;response;RNA methylation;Running;Sample Size;Sampling;sequencing platform;single cell ATAC-seq;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;Statistical Data Interpretation;statistics;Study models;Survival Analysis;Techniques;terabyte;Testing;therapeutic target;tool;transcriptome;transcriptome sequencing;transcriptomics;University of Texas M D Anderson Cancer Center;Visualization


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Rare Diseases

PHR: CORE 3_MULTIPARAMETER IMAGING AND PATHOLOGY: NARRATIVE The MPIP core will: 1) collect and distribute specimens and patient samples to P01 investigators, providing for a uniform pathology review and classification all P01 clinical specimens, and 2) develop and provide state-of the art imaging services critical to successful molecular analysis of mouse and human LBCL across the P01.

PI_NAMEs: PATEL, SANJAY SHUTISH (contact)

PROJECT_TERMS: Address;Animal Model;B-Cell Lymphomas;bioinformatics pipeline;Biological Assay;Biological Models;Biological Specimen Banks;Biological Specimen database;biomarker identification;Biometry;Blood specimen;cellular imaging;Classification;Clinical;clinical prognostic;clinically relevant;Collaborations;Collection;Computational Biology;Cytogenetics;Data;data repository;Databases;demographics;Development;Diagnosis;Diagnostic;Disease Resistance;DNA;Ensure;Epigenetic Process;Goals;Hematopathology;Human;human disease;Image;image archival system;Immunofluorescence Immunologic;Immunologics;Immunophenotyping;In Situ;Individual;individual patient;Information Services;Information Systems;Infrastructure;innovation;Institution;Laboratory Study;large cell Diffuse non-Hodgkin's lymphoma;Link;Lymphoma;Methods;minimally invasive;Molecular;Molecular Analysis;molecular marker;molecular pathology;multidisciplinary;Mus;Needle biopsy procedure;new technology;new therapeutic target;novel;Outcome;Pathologic;Pathology;pathology imaging;Patients;pre-clinical;Procedures;Prognostic Factor;prognostication;Recording of previous events;Records;Research Personnel;response;RNA;sample collection;Sampling;screening;Secure;Services;shared database;Specimen;Stains;standard of care;Techniques;Technology;Test Result;therapeutic target;Tissue Banks;Tissue Microarray;tissue resource;Tissue Sample;Tissues;transcriptomic profiling;Translational Research;Treatment outcome;tumor;University of Texas M D Anderson Cancer Center;Validation;Work

PROJECT_TITLE: Core 3: MPIP.


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative The goals of this interdepartmental Ph.D. program are (1) to organize neuroscientists at Harvard Medical School, its affiliated hospitals, and Harvard College into a single training faculty cohort; and (2) to train research scientists and teachers who are interested in mental health, diseases of the nervous system, and fundamental mechanisms of the brain.

PI_NAMEs: ASSAD, JOHN  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TITLE: Ph.D. Training in Neuroscience

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (03)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Niacin, or vitamin B3, is an essential nutrient linked to NAD+ metabolism, and critical to energy metabolism. It must be consumed through the diet since we are unable to synthesize or store it, and most metabolic pathways related to niacin and NAD+ are anabolic (involved in synthesis, or reclamation/salvage of the molecule). This application explores the potential relationship of 4PY, a terminal metabolite of NAD+ and niacin metabolism, with cardiovascular health, using analytical, genetic, molecular, cellular and physiological approaches, and preclinical models of disease.

PI_NAMEs: HAZEN, STANLEY L (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: 2-hydroxypyridine;Acute;adenovirus mediated delivery;Animal Model;Aorta;Arterial Fatty Streak;Arterial Injury;Arteries;Atherosclerosis;Attention;Biological Assay;Biology;Blood Platelets;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Cell model;Cells;Cereals;Cessation of life;Chemicals;Chronic;Clinical;Clinical Trials;clinically significant;cohort;combat;Consumption;Coronary;Country;Coupled;Data;Development;Diet;Diet and Nutrition;dietary;Disease;disease model;Disease Outcome;disease phenotype;Dose;Energy Metabolism;Event;expectation;Food;Fortification;Fostering;Gene Expression Profile;Genes;Genetic;Genetic study;genetic variant;genome wide association study;genome-wide;gut microbiome;Health;Hepatic;Human;Human Genetics;in vivo;Inflammatory;insight;Institutionalization;Intake;Investigation;Isomerism;knock-down;Knockout Mice;LDL Cholesterol Lipoproteins;Link;liquid chromatography mass spectrometry;Low-Density Lipoproteins;Mass Spectrum Analysis;Medicine;Metabolic Pathway;Metabolism;metabolomics;Microbiology;Micronutrients;Molecular;monocyte;mortality risk;mouse model;Myocardial Infarction;National Health and Nutrition Examination Survey;Nature;Niacinamide;Nicotinamide N-Methyltransferase;Nicotinic Acids;novel;novel diagnostics;novel therapeutics;Nutrient;nutrition;Pathogenesis;Pathway interactions;Pellagra;Phenotype;Physiological;Plasma;Plasma Enhancement;Pre-Clinical Model;programs;Public Health;Pyridones;recruit;Renal function;Research;Residual state;Risk;Risk Factors;safety assessment;short hairpin RNA delivery;stable isotope;Stroke;Structure;Study models;Testing;Thrombosis;thrombotic;Tryptophan;ultrasound;Validation;Variant;Vascular Endothelial Cell;vascular inflammation;Work

PROJECT_TITLE: Nutrition, terminal NAD metabolites and cardiovascular disease

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Immunization;Immunotherapy;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE: Recent FDA accelerated approvals of aducanumab and lecanemab for early-stage Alzheimer’s disease, and reported positive phase 3 results from donaneab, provide the first disease-modifying treatments to date, albeit with modest-to-moderate slowing of cognitive decline and the presence of potentially fatal vascular side effects known as Amyloid-Related Imaging Abnormalities (ARIA) in a subset of treated patients. Here, we will test our hypothesis that anti-amyloid antibodies with higher binding affinities for vascular amyloid are more likely to cause ARIA by comparing the biological and pathological binding characteristics of 4 clinical anti-amyloid antibodies to parenchymal plaque and vascular amyloid in human AD brain tissues and staining in amyloid mouse models. In addition, we will compare in vivo the ability of the murine analogs of 3 of the anti-amyloid antibodies to both lower plaque and vascular amyloid burden and induce ARIA in 5XE4 mice and, test antibody cocktails containing an anti-amyloid antibodies and either an anti-APOE mAb or an anti-complement C1s1 antibody to mitigate ARIA.

PI_NAMEs: LEMERE, CYNTHIA A (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: abeta accumulation;Abeta clearance;Acceleration;Aducanumab;Adverse effects;Affinity;aged;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Amyloid;Amyloid beta-Protein;Amyloid deposition;analog;Antibodies;Antibody Affinity;antibody immunotherapy;antibody test;Antibody Therapy;Apolipoprotein E;apolipoprotein E-4;Autopsy;Binding;Biochemical;Biological;Blocking Antibodies;Blood - brain barrier anatomy;Blood Vessels;brain tissue;Cells;Cerebral Amyloid Angiopathy;Cerebrovascular system;Characteristics;Classical Complement Pathway;Clinic;Clinical;Combined Modality Therapy;Complement;Complement Activation;Complement component C1s;Deposition;Disease;Edema;Enzyme-Linked Immunosorbent Assay;Excision;extracellular;Extravasation;Face;Health;Hemorrhage;high risk;Human;Image;Immune;immune activation;Immune response;Immunohistochemistry;Immunoprecipitation;Immunotherapy;Impaired cognition;Impairment;improved;in vivo;Inflammation;Inflammatory Response;Injections;Measures;Mediating;Medicare;Methods;Modeling;Monoclonal Antibodies;monomer;mouse model;Mus;Neuroglia;neuroinflammation;novel;Passive Immunization;Pathologic;patient subsets;Patients;Pharmaceutical Preparations;Phase;Phase III Clinical Trials;phase III trial;Positron-Emission Tomography;Press Releases;prevent;Proteins;Recombinants;recruit;Reporting;research study;Risk;Safety;sample fixation;Senile Plaques;side effect;Signal Transduction;Site;Stains;Swelling;targeted treatment;Testing;Time;Uncertain Risk;vascular inflammation;β-amyloid burden

PROJECT_TITLE: Understanding and Mitigating Vascular Side-Effects Associated with Anti-Amyloid Immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-M (91)]


NIH_SPENDING_CATS: Transplantation

PHR: PROJECT NARRATIVE Red blood cell (RBC) transfusion is a powerful therapeutic tool and the most common form of transplantation in clinical practice, yet the immune system of the transfusion recipient can respond to these foreign RBCs and cause harm through antibody production. We have developed a mouse model of RBC transfusion to identify the early signals that trigger the immune system to respond to donor RBCs. Such an understanding is an important step towards developing targeted therapies to block this detrimental immune response, especially in those who require lifelong RBC transfusion support such as those with sickle cell disease.

PI_NAMEs: EISENBARTH, STEPHANIE CAROLINE;WILLIAMS, ADAM  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Adsorption;Alloantigen;Allogenic;Alloimmunization;Animal Model;Antibodies;Antibody Formation;Antibody Response;Antigens;B-Cell Activation;B-Lymphocytes;Binding;Biological Assay;Biological Models;Biology;Blood;CD4 Positive T Lymphocytes;Cell Line;cell type;Cells;Chronic;Clinical;clinical care;clinical practice;Collaborations;cytokine;Data;Dendritic cell activation;Dendritic Cells;Disease;DNA;Early identification;Erythrocyte Transfusion;Erythrocytes;Excision;Family;Fetus;Graft Rejection;high risk;Homologous Transplantation;Human;humoral immunity deficiency;Immune;immune activation;Immune response;Immune system;Immunologic Receptors;improved;In Vitro;Inflammation;inhibitor;Innate Immune Response;Innate Immune System;insight;Isoantibodies;Life;Ligands;Mediating;Medical;Methods;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Nature;new therapeutic target;Newborn Infant;nucleotide receptor;Nucleotides;Organ Transplantation;pathogen;Pathology;Pathway interactions;Patients;Pattern recognition receptor;Phagocytosis;Pharmaceutical Preparations;pharmacologic;Pre-Clinical Model;prevent;Process;Production;Quality of Care;Reaction;receptor;Receptor Cell;Receptor Signaling;Reporter;response;RNA;Role;Safety;screening;Sickle Cell Anemia;Signal Transduction;Solid;Spleen;Splenocyte;Sterility;System;T-Lymphocyte;targeted treatment;Testing;Therapeutic;TLR7 gene;Toll-like receptors;tool;Transfusion;Transplantation;Work

PROJECT_TITLE: Innate immune triggers of alloantibody induction

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Project Narrative Alzheimer’s disease and related dementias (ADRD) are devastating brain disorders that disproportionately affect US minorities, who are underrepresented in ADRD genetics research. This supplement to the Alzheimer’s Disease Sequencing Project (ADSP)-Phenotype Harmonization Consortium will fund the preparation of electronic medical record-based phenotypes and research data from the Million Veterans Program (MVP)—one of the world’s largest diverse genetic research cohorts, including nearly 1 million US Veteran Volunteers—for eventual coordinated investigation by ADSP investigators. This work will therefore increase the diversity and power of future ADSP genetic studies.

PI_NAMEs: HOHMAN, TIMOTHY J (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Address;Affect;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;biobank;Biological Markers;Black race;Blood Vessels;Brain Diseases;brain magnetic resonance imaging;Cardiovascular Diseases;Caring;Charge;Chromosome Mapping;Clinical;clinical imaging;Code;cohort;Collaborations;Communities;comorbidity;computational platform;Computerized Medical Record;Data;data access;data analysis pipeline;Data Commons;data dictionary;Data Files;data format;data integration;Databases;dementia risk;demographics;Deposition;Development;Diabetes Mellitus;Diagnosis;Diagnostic;Education;endophenotype;executive function;Frequencies;Funding;Future;Genetic;Genetic Research;Genetic Risk;Genetic study;genome sequencing;Genotype;Heterogeneity;Hispanic;human old age (65+);Image;imaging facilities;Impaired cognition;improved;Individual;Infrastructure;Investigation;machine learning algorithm;machine learning classification;machine learning model;Manuals;Maps;Medical;Medical center;Metadata;Methods;Minority;Neurocognitive;neurocognitive test;neuroimaging;neuropathology;Neuropsychology;Output;Participant;Performance;Phenotype;phenotypic data;Pilot Projects;Policies;Population;Population Heterogeneity;Preparation;Prevalence;Privacy;Process;programs;Protocols documentation;Race;Reporting;Research;Research Personnel;Risk;risk variant;Short-Term Memory;Site;structured data;symptomatology;Testing;Trans-Omics for Precision Medicine;Underrepresented Populations;United States;Validation;vascular risk factor;Veterans;Veterans Health Administration;volunteer;whole genome;Work

PROJECT_TITLE: MVP Data Integration into the ADSP Phenotype Harmonization Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-S (J1)]


ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE: OVERALL AND SIX ESSENTIAL CHARACTERISTICS The overarching goal of the Sidney Kimmel Cancer Center (SKCC) is to leverage research expertise to reduce the overall incidence, burden, and mortality from cancer in Greater Philadelphia and beyond. SKCC goals are realized through unique strengths in addressing cancer problems through collaboration across basic, clinical, and population research disciplines. SKCC is nucleated at Thomas Jefferson University (TJU) and enriched by fully integrated research consortium partner from Drexel University (DU); building on these strengths, SKCC focuses on addressing catchment area needs through nurturing transdisciplinary research, expanding innovative research capabilities, extending outreach and clinical research into the community, and enhancing the pace of bench-to-bedside discovery.

PI_NAMEs: CHAPMAN, ANDREW  (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Address;Adult;Advanced Malignant Neoplasm;anti-cancer research;Area;barrier to care;Basic Science;Belief;bench to bedside;bioimaging;Bioinformatics;Biometry;Breathing;Cancer Burden;cancer care;Cancer Center;Cancer Control;Cancer Detection;cancer genomics;cancer health disparity;Cancer Patient;cancer risk;cancer therapy;Catchment Area;cellular oncology;Characteristics;Charge;Cities;Clinical;clinical care;Clinical Research;Clinical Trials;Collaborations;college;Communities;community engagement;Community Outreach;Compassion;Comprehensive Cancer Center;Comprehensive Health Care;County;Data Science;Delaware;Development;Discipline;Disease;Disparity;disparity elimination;Disparity population;Diverse Workforce;diversity and equity;diversity and inclusion;Effectiveness;Environment;Equity;equity, diversity, and inclusion;Evolution;Family;first-in-human;Flow Cytometry;Fostering;Funding;Goals;health equity;health equity promotion;Heart;Hospitals;Human;Immune Targeting;Immunologic Monitoring;immunoregulation;improved;Incidence;Informatics;Infrastructure;innovation;Institution;interdisciplinary collaboration;Intervention;Investments;Joints;Lead;Leadership;lens;life span;Life Style;Malignant Neoplasms;Medical Research;member;Mission;molecular oncology;mortality;NCI-Designated Cancer Center;New Jersey;next generation;novel;novel strategies;operation;Outcome;Outreach Research;Pathology;Peer Review;Pennsylvania;personalized cancer care;Phase;Philadelphia;Physicians;Population;population health;Population Research;Prevention strategy;programs;Quality of life;Regulation;Research;Research Personnel;Resource Sharing;Role;safety net;Scientist;Services;social health determinants;Strategic Planning;structural biology;survivorship;Talents;Testing;Training;Training and Education;translational oncology;Translational Research;underserved community;Underserved Population;United States National Institutes of Health;Universities;Urban Community;Vision;Work

PROJECT_TITLE: Translational Research in Cancer

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: HUESSER, MATTHEW HOWARD (contact)

PROJECT_TERMS: Adherence;anti-cancer research;arm;Automobile Driving;base;Businesses;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer research center director;career;Catchment Area;Clinic;Clinical;Clinical Management;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community engagement;Community Outreach;Contracts;Data Collection;Development;digital platform;Documentation;Environment;equity, diversity, and inclusion;Extramural Activities;Faculty Recruitment;Fostering;Funding;Goals;Grant;Growth;Guidelines;Human Resources;improved;innovation;Institution;interdisciplinary collaboration;Investments;Leadership;Malignant Neoplasms;Marketing;meetings;member;Mission;Monitor;next generation;operation;Operations Research;Pathway interactions;Philadelphia;Process;programs;Publications;Reporting;Research;Research Activity;Research Infrastructure;Research Institute;Research Personnel;Resource Sharing;Resources;Science;Services;Strategic Planning;Structure;System;Time;Training;Translating;Translational Research;Universities;Vision;Work

PROJECT_TITLE: Cancer Center Administration


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: KIM, FELIX JINHYUN (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Basic Science;Cancer Burden;Cancer Center;cancer health disparity;career;career development;Catchment Area;Characteristics;Clinical;Clinical Research;Clinical Sciences;clinical trial implementation;Communities;community engagement;Community Outreach;Competence;Comprehensive Cancer Center;Development;Disparity;Diverse Workforce;diversity and equity;Doctor of Philosophy;Education;Environment;equity, diversity, and inclusion;expectation;Faculty;Fellowship;Fostering;Funding;Goals;Grant;Growth;Health;Health Disparities Research;high school;Individual;Infrastructure;innovation;Institution;Investments;Laboratories;Leadership;Learning;learning community;Malignant Neoplasms;member;Mentors;Mentorship;Mission;NCI Center for Cancer Research;next generation;novel;Population Sciences;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Preparation;Productivity;programs;Publications;Research;Research Personnel;Research Training;Resources;Training;Training Activity;Training and Education;training opportunity;Training Programs;Translational Research;undergraduate student;Universities;Work

PROJECT_TITLE: Cancer Research Training and Education Coordination (CRTEC)