ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

PHR: PROJECT NARRATIVE Variety of genetic mutations can cause pediatric disease where white matter in the brain is destroyed or not properly formed. However, despite clinical genome sequencing many of these children with devastating brain disease remain undiagnosed. This project aims to resolve all cases of undiagnosed white matter disease using new sequencing technology combined with disease-specific model systems to provide novel insights into molecular targets for disease diagnosis and advance therapeutic intervention.

PI_NAMEs: BERNARD, GENEVIEVE ;BONKOWSKY, JOSH LEITCH;PASTINEN, TOMI  (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Acceleration;Affect;Alleles;Artificial Intelligence enhanced;base;Biological Models;Blood specimen;Brain;Brain Diseases;Candidate Disease Gene;candidate validation;Cells;Central Nervous System;Cerebrum;Cessation of life;Child;Childhood;Cities;Classification;Clinical;clinical sequencing;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Complex;Cytosine;Data;data resource;Data Set;Detection;Development;Diagnostic;disability;Disease;disease diagnosis;DNA;DNA Methylation;DNA Sequence Alteration;endophenotype;exome;Family;follow-up;functional genomics;Generations;Genes;Genetic Diseases;Genetic Transcription;genetic variant;Genome;genome analysis;genome sequencing;genomic data;Genomic medicine;genomic profiling;Genomics;Goals;Graph;Haploidy;Health system;Homeostasis;Human Genome;in vivo;Incidence;Individual;induced pluripotent stem cell;Inherited;insight;Kansas;leukodystrophy;Live Birth;Maps;Methylation;methylome;model organism;Modeling;Molecular Diagnosis;Molecular Target;Mutation;Myelin;myelination;Nervous System Disorder;Neurologic;novel;novel sequencing technology;Nucleotides;Oligodendroglia;Parents;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Pediatric cohort;Peripheral Blood Mononuclear Cell;phenome;Phenotype;Prognosis;programs;Protein Isoforms;Rare Diseases;rare genetic disorder;reference genome;Regulatory Element;Repetitive Sequence;Resistance;Resources;Retinal blind spot;RNA;Running;Sampling;Structure;Tandem Repeat Sequences;Therapeutic Intervention;tool;Universities;Untranslated RNA;Utah;Variant;variant detection;variant of unknown significance;white matter;White Matter Disease;whole genome;Zebrafish

PROJECT_TITLE: Unraveling the Genomic Causes for Unsolved Leukodystrophy Patients by HiFi-GS

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project narrative Eukaryotic protein kinases regulate important cellular processes through their ability to phosphorylate themselves and substrate proteins and alteration of the mechanisms that control kinase activation leads to pathological conditions including cancer. Here we will investigate a novel mechanism of kinase activation through hydroxylation of proline residues by proline hydroxylase enzymes. We will determine the functional impact of the signaling pathways converging on proline hydroxylases, the cancer phenotypes elicited in the mouse brain by dysregulation of this novel pathway of kinase activation and the consequences on the global proteome and phosphoproteome.

PI_NAMEs: LASORELLA, ANNA  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Address;Alanine;Automobile Driving;beta catenin;Binding;Biology;Brain;brain control;Brain Neoplasms;cancer stem cell;cancer type;Cell Physiology;Cells;comparative;Complex;computerized tools;Cyclic AMP-Dependent Protein Kinases;Cyclin-Dependent Kinases;Data;Development;Disabling;Enzymes;Event;experimental study;Family;Genetic study;Glioblastoma;Glioma;Gliomagenesis;Glycogen Synthase Kinase 3;Glycogen Synthase Kinases;Hydroxyl Radical;Hydroxylation;ID2 gene;Impairment;Indolent;inhibitor;Inhibitor of Differentiation Proteins;inorganic phosphate;interest;Knock-in Mouse;Knowledge;Laboratories;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;member;Metabolic;Metabolism;Mitochondria;Mitogen-Activated Protein Kinases;Molecular;Molecular Conformation;mouse model;Mus;mutant;Mutation;Neurons;Normal Cell;notch protein;novel;Oncoproteins;Oxygen;Pathologic;Pathway interactions;Phenotype;phosphoproteomics;Phosphorylation;Phosphotransferases;Play;polypeptide;Primary Neoplasm;Procollagen-Proline Dioxygenase;prognostication;Proline;Proline-Directed Protein Kinases;promoter;protein activation;Protein Isoforms;Protein Kinase;Proteins;Proteome;Proteomics;Proto-Oncogene Proteins c-akt;Reaction;recruit;Regulation;Regulatory Pathway;Reporting;Role;self-renewal;Signal Pathway;Signal Transduction;Site;Specificity;therapeutic target;Tissues;Translations;tumor;Tumor Promotion;Tumor Suppressor Proteins;tumorigenesis;Tyrosine Phosphorylation;ubiquitin ligase;Work

PROJECT_TITLE: Activation of protein kinases by proline hydroxylation

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Summary Pathological increases in adipose tissue, including white adipocytes studied here, are major risk factors for Type 2 diabetes and cardiovascular diseases, whereas brown adipose tissue has potential anti-obesity properties. White adipose tissue has an inherent plasticity to turn on the brown adipocyte gene program to increase energy expenditure. Therefore, understanding and manipulating the biological programs governing these two distinct adipose cell phenotypes may have therapeutic potential to combat obesity, insulin resistance, and heart disease.

PI_NAMEs: RAJBHANDARI, PRASHANT  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Ablation;Achievement;Address;Adipocytes;Adipose tissue;Adrenergic Agents;Adult;Anti-Inflammatory Agents;ATAC-seq;Biological;Bone Marrow;Bone Marrow Transplantation;Brown Fat;Cardiovascular Diseases;Cell secretion;cell type;Cells;chemokine;ChIP-seq;Chromatin;combat;cytokine;Data;Diabetes Mellitus;diet-induced obesity;Doxycycline;energy balance;Energy Metabolism;Enhancers;Event;Fatty acid glycerol esters;Fluorescence-Activated Cell Sorting;Future;Gene Expression;Gene Expression Profile;gene network;gene repression;Genes;Genetic Transcription;genome-wide;glucose tolerance;Goals;Heart Diseases;Hematopoietic;Homeostasis;Immune;improved;Inflammation;Inflammatory;Insulin Resistance;insulin sensitivity;Interleukin-10;interleukin-10 receptor;knock-down;Knockout Mice;Knowledge;Link;Mediating;Metabolic;Metabolism;Mitochondria;Modeling;Molecular;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity treatment;Pathologic;Pathway interactions;Phenotype;Pilot Projects;Population;Process;Production;programs;Promoter Regions;Property;Publishing;Receptor Signaling;reconstitution;Regulation;Reporting;Respiration;Risk Factors;Role;Signal Transduction;single-cell RNA sequencing;STAT3 gene;T-Lymphocyte;Testing;Therapeutic;Thermogenesis;transcriptome sequencing;Work

PROJECT_TITLE: Interleukin-10 mediated immune cell-adipocyte crosstalk in adipose thermogenesis

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Rare Diseases

ORG_CITY: COLLEGE PARK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PUBLIC HEALTH RELEVANCE This proposal is relevant to public health because it will introduce novel, nonperturbative, nondestructive, elasticity-based metrics and finite element modeling to the evaluation and management of keratoconus progression, a disease that is significantly more common than previously thought, and for laser vision correction for myopia, which is reaching epidemic proportions in most developed countries, including the US. This approach will allow for the first in vivo analysis of the ability of Brillouin microscopy to predict keratoconus progression before vision loss occurs and facilitate individualizing laser vision correction for myopia and corneal cross-linking for keratoconus.

PI_NAMEs: RANDLEMAN, JAMES BRADLEY;SCARCELLI, GIULIANO  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Address;Automation;Behavior;biomechanical test;Biomechanics;Blindness;Clinical;clinical imaging;clinically relevant;Cornea;crosslink;Data;density;Developed Countries;Diagnosis;diagnostic value;Disease;Disease Progression;Early identification;Elasticity;Elements;Epidemic;Evaluation;Eye;Funding;Goals;Heterogeneity;Image;improved;in vivo;in vivo evaluation;individualized medicine;instrument;Keratoconus;Keratoplasty;Laser In Situ Keratomileusis;Lasers;Maps;Measurement;Measures;mechanical properties;Mechanics;Microscope;Microscopy;Modeling;Modulus;Morphology;Motion;Myopia;next generation;novel;Operative Surgical Procedures;Optics;Outcome;outcome prediction;Pathological Dilatation;Patients;Pattern;Performance;Photorefractive Keratectomy;Prediction of Response to Therapy;predictive modeling;Predisposition;Prevalence;procedure safety;Procedures;Process;programs;progression risk;Property;Public Health;public health relevance;Quality of life;Refractive Errors;Research;Resolution;response;Safety;Scanning;screening;Shapes;Side;Surgical incisions;surgical risk;Techniques;technological innovation;Technology;Testing;Thick;Time;tomography;tool;Treatment outcome;treatment planning;Vision;Work

PROJECT_TITLE: Cornea biomechanical analysis with Brillouin microscopy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project narrative  Neurons and glia form highly specific attachments during brain development. Disruption of neuron- glia attachments is associated with neurodevelopmental disorders, including autism and schizophrenia, as well as long-term neurological risk, including failure to recover from stroke or traumatic brain injury. This project uses a precisely defined neuron-glia attachment in the model organism C. elegans to identify the genes that enable a single neuron to select the correct glial partner.

PI_NAMEs: HEIMAN, MAXWELL  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Ablation;Adherens Junction;Adhesions;Affect;Afferent Neurons;Alpha-mannosidase;Animals;autism spectrum disorder;Award;BAIAP1 gene;Behavioral Assay;Brain;Cadherins;Caenorhabditis elegans;Calcium;Cell Adhesion;Cell Adhesion Molecules;cell type;Cell-Matrix Junction;Cells;Cilia;Collection;Complex;Data;Defect;Dendrites;Dendritic Spines;Development;Developmental Process;Dorsal;Embryo;Epithelium;Event;experience;Failure;Genes;Genetic;genetic manipulation;Genetic Screening;Goals;Growth;Homologous Protein;Human;Image;innovation;Lasers;Lateral;Learning;Length;Mediating;model organism;Modeling;Modification;Molecular;Morphology;mutant;Neural Cell Adhesion Molecule L1;Neurodevelopmental Disorder;Neuroglia;Neurologic;Neurons;Nose;novel;Organ;Oxygen;Polysaccharides;Positioning Attribute;Process;Proteins;Proteoglycan;response;Risk;Role;Scaffolding Protein;Schizophrenia;Sensory;Shapes;Site;Stereotyping;Stimulus;Stretching;Stroke;Structure;superresolution microscopy;Synapses;System;Traumatic Brain Injury;Tube;Visualization;Work

PROJECT_TITLE: Development of specific neuron-glia attachments

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NORTHPORT

ORG_NAME: NORTHPORT VA MEDICAL CENTER

PHR: This grant proposal will investigate how to optimize antibodies to the polysaccharide capsule of carbapenem resistant Klebsiella strains. We will use animal models to determine what combination and which antibodies are the best candidates. These infections are common both in hospitalized military personnel and in Veterans. They are very difficult to treat and associated with a high mortality. _____________________________________________________________________________________________________________________ __________________ PHS 398 (Rev. 5/01) Page _

PI_NAMEs: FRIES, BETTINA  (contact)

PROJECT_TERMS: Adjuvant Therapy;aerosolized;Affinity;alternative treatment;Animal Model;Anti-Infective Agents;Antibiotics;Antibodies;Applications Grants;Bacteria;Binding;Biological Assay;capsule;carbapenem resistance;Collaborations;combat;Communities;comorbidity;COVID-19 pandemic;Data;Diagnosis;Disease;emerging pathogen;Encapsulated;epidemiology study;Epitopes;Exhibits;experience;Extended-spectrum β-lactamase;Funding;Goals;Healthcare;Heterogeneity;Hospitalization;Hospitals;Hour;Human;In Vitro;in vivo;Infection;Inflammatory Response;Injury;intraperitoneal;Klebsiella;Klebsiella pneumoniae;Laboratories;Lead;lead candidate;lead optimization;Life;Lung;Lung infections;Methods;Military Personnel;Modality;Modeling;Monoclonal Antibodies;Monoclonal Antibody Therapy;mortality;multi-drug resistant pathogen;Multiple Bacterial Drug Resistance;murine monoclonal antibody;Mus;mutant;Nebulizer;novel;pathogen;patient population;Patients;Persons;Pneumonia;pneumonia treatment;Polymyxins;Polysaccharides;preservation;Prevalence;prevent;protective efficacy;Proteins;Publishing;Rehabilitation Centers;Renal function;Reporting;Resistance;resistant Klebsiella pneumoniae;Risk;Sepsis;severe COVID-19;Soldier;Solid;Specificity;State Hospitals;Testing;Texas;Therapeutic Monoclonal Antibodies;tigecycline;United States;Urinary tract infection;Vaccines;Variant;Veterans;Wound Infection

PROJECT_TITLE: Optimization of therapeutic mAbs to carbapenem resistant Klebsiella clone ST258

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 INFB-K (01)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will provide mechanistic knowledge about the generation of the optokinetic reflex from the retina to the motor response. Such fundamental knowledge will enable more sensitive diagnosis of nervous system disorders, with the possibility of precisely linking specific OKR characteristics to specific pathology, thus advancing the clinical use of this simple, non-invasive, and evolutionarily conserved reflex.

PI_NAMEs: DUNN, FELICE A (contact);KOLODKIN, ALEX L

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: attenuation;Behavior;behavior influence;Behavioral;cell behavior;Cell Physiology;cell type;Cells;Characteristics;Clinic;Clinical;clinical application;Computer Models;Cues;Dedications;Dependence;Development;Diagnosis;Diagnostic;differential expression;Disease;Environment;Eye;Eye Movements;Functional disorder;ganglion cell;Generations;Genes;Genetic;Goals;Head Movements;Health;Image;improved;Individual;Inferior;insight;Knowledge;Lead;Ligands;Link;loss of function;Maps;Measures;Molecular;Morphology;Motion;Motor;mouse genetics;Nervous System Disorder;nervous system disorder diagnosis;Neurologic;Neurons;Noise;Optics;Organism;Outcome;Output;Pathology;Perception;Physiological;Population;preservation;Process;Property;Public Health;receptor;Receptor Signaling;Reflex action;Research;response;Retina;Role;Sensory;Signal Pathway;Signal Transduction;single cell sequencing;statistics;Stimulus;Structure;Synapses;System;Translating;vestibular system;Vision;Vision Disorders;Visual;Visual System;Work

PROJECT_TITLE: Retinal mechanisms underlying the optokinetic reflex

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Hypertension;Kidney Disease

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE Renin released from juxtaglomerular cells, the first-step and rate-limiting enzyme of the circulating renin- angiotensin-aldosterone system, plays an essential role in the regulation of extracellular fluid volume and blood pressure. The most important among the control mechanisms of renin release is a pressure-sensing mechanism, denominated as the intrarenal baroreceptor, however, the nature of the intrarenal baroreceptor and in particular, the central questions about this pressure-sensing mechanism: what the exact mechano-sensor is in juxtaglomerular cells and how it controls renin synthesis and secretion, remain elusive. This project aims to determine whether syndecan-1 is a key mechano-sensor of the intrarenal baroreceptor mechanism in juxtaglomerular cells that controls renin synthesis and secretion, regulates the circulating renin-angiotensin- aldosterone system, and thus contributes to the maintenance of fluid and electrolyte homeostasis and blood pressure.

PI_NAMEs: WEI, JIN  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: abdominal aorta;Address;Affect;Angiotensin I;Angiotensinogen;Aortic coarctation;arteriole;Blood Pressure;Blood Vessels;C-terminal;Cell Physiology;Cells;Characteristics;Chondroitin Sulfates;Circulation;Cytoplasmic Tail;Cytoskeleton;differential expression;Electrolytes;Elements;Endocrine;Environment;Enzymes;Excretory function;extracellular;Extracellular Domain;Extracellular Fluid;Feedback;Genes;Genetic;Genetic Markers;Heparitin Sulfate;Homeostasis;Impairment;in vitro Model;in vivo Model;Juxtaglomerular Apparatus;Juxtaglomerular Cell;Kidney;kidney cell;kidney vascular structure;Knock-out;Left;Liquid substance;Maintenance;Membrane;Microdissection;Molecular;mouse model;mRNA Expression;Mus;N-terminal;Nature;novel;Perfusion;Pilot Projects;Play;preservation;Pressoreceptors;pressure;Production;protein expression;Proteoglycan;Regulation;renal artery;Renin;Renin-Angiotensin-Aldosterone System;Resolution;response;Role;single-cell RNA sequencing;Smooth Muscle Myocytes;Sodium;syndecan;Systemic blood pressure;Techniques;tool;transcriptome;transcriptomic profiling;urinary;Vascular resistance;Vascular Smooth Muscle

PROJECT_TITLE: Identification of a mechanosensor in juxtaglomerular cells for the regulation of renin synthesis and secretion

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: Aurora

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Understanding how virus-associated, non-infectious, long-lasting exosomes reprogram cells to be more permissive to infection and to produce a proinflammatory environment provides a novel mechanism by which virus infection causes pathologies distal from the original site of infection and expands the spectrum of virus- associated diseases. These mechanistic steps will provide therapeutic targets to prevent persistent pathologies produced by these virus-induced exosomes.

PI_NAMEs: BUBAK, ANDREW N (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: acute infection;Acyclovir;Adult;Afferent Neurons;Aging;Anti-viral Agents;Anti-viral Response;antigen detection;Area;Astrocytes;Autonomic ganglion;Biological Assay;Biological Process;Blood Vessels;Cell Communication;Cell Reprogramming;cell type;Cells;Central Nervous System;cerebrovascular;Chickenpox;Chronic;chronic pain;Cranial Nerves;cytokine;Data;Diagnosis;Diameter;Disease;Distal;Distant;ds-DNA;Endosomes;Exanthema;exosome;Exposure to;extracellular vesicles;Fibroblasts;Genetic Transcription;Herpes zoster disease;Herpesvirus 1;Herpesvirus Type 3;Hour;Human;IL8 gene;Immune Evasion;Immune response;Immune system;Immunosuppression;Individual;Infection;Inflammation;Inflammatory;inflammatory milieu;Interferon Type II;Interferons;Interleukin-1 beta;Interleukin-10;Interleukin-2;Interleukin-4;Interleukin-5;Interleukin-6;Intervention;Keratitis;Mass Spectrum Analysis;Mediating;MicroRNAs;Myelitis;nerve supply;Neurons;neurotropic virus;next generation sequencing;novel;Nucleic Acids;Organ;pathogen;Pathogenicity;Pathologic;Pathology;Pathway interactions;permissiveness;persistent symptom;Plasmids;Population;Postherpetic neuralgia;prevent;Primary Infection;Process;programs;Proteins;Proteomics;Research;Research Personnel;response;Role;Sensory;Site;Small RNA;Spinal Cord;Spinal Cord Diseases;spinal nerve posterior root;Stroke;System;Testing;therapeutic target;therapy development;Time;Tissues;TNF gene;Transcript;Transfection;varicella-zoster virus immediate early protein 62;Vascular Diseases;Vasculitis;Viral;Viral Antigens;viral detection;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Remote cellular reprogramming by non-infectious, pathogenic varicella zoster virus exosomes

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


ED_INST_TYPE: SCHOOLS OF NUTRITION

NIH_SPENDING_CATS: Aging;Atherosclerosis;Brain Disorders;Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Neurosciences;Nutrition;Prevention;Stroke

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: This project renewal will leverage the power of serial biomarkers measures to investigate the interrelationships of novel microbiome-generated AAA metabolites with initiation, extent, and clinical onset of subclinical CVD, clinical CHD, and total mortality. Primary aims include: (1) to investigate the independent relationships of serial measures of plasma aromatic amino acid (AAA)-derived microbial metabolites with longitudinal onset and progression of subclinical CVD; (2) to investigate the independent relationships of serial measures of plasma AAA-derived microbial metabolites with incident CVD events; (3) to investigate the independent relationships of serial measures of plasma AAA-derived microbial metabolites with total mortality. Secondary Aims include focuses to investigate (a) the independent dietary, lifestyle, and demographic predictors of plasma AAA- derived microbial metabolites and change in these metabolites over time in two diverse community-based populations; and (b) potential effect modification of metabolite-outcome associations by age, sex, race/ethnicity, socioeconomic status, background diet, lipid-lowering medication use, renal function, and prevalent CVD.

PI_NAMEs: HAZEN, STANLEY L;MOZAFFARIAN, DARIUSH  (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Adhesions;Adult;Age;age related;Area;Aromatic Amino Acids;Atherosclerosis;beef;Biological;Biological Markers;Black race;Blood specimen;Blood Vessels;brain health;Cardiac;cardiovascular health;Chickens;Chinese;Circulation;Clinical;clinically relevant;cohort;Communities;Complement;Consumption;coronary artery calcium;Cresol;Dairying;Data;Deamination;design;Development;Diet;diet-induced obesity;dietary;Disease;egg;Enzymes;Ethnic Origin;Evaluation;experimental study;Fermentation;Fishes;Future;gut microbes;gut microbiome;Health;Hispanic;host microbiome;Human;human population study;Indican;Indoles;Infarction;interest;Intervention Studies;Intestinal permeability;Ischemic Stroke;Life;Life Style;Link;Lipids;Liver;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;Measures;Meta-Analysis;Metabolic;Metabolism;microbial;microbiome;middle age;Modification;Molecular;mortality;Multi-Ethnic Study of Atherosclerosis;Neurologic;new therapeutic target;novel;Nutrient;Outcome;oxidation;Oxidative Stress;Participant;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacological Treatment;Phenylalanine;Plant Proteins;Plasma;platelet function;Population;population based;Preventive treatment;Propionic Acids;prospective;Prospective cohort;Protein Biosynthesis;Race;Renal function;Reproducibility;Research;Residual state;Risk;Risk Factors;sex;small molecule;Smoking;Socioeconomic Status;Source;Specificity;stable isotope;stroke event;stroke outcome;stroke risk;Sulfate;Testing;Thrombosis;Time;Tryptophan;Tryptophan Metabolism Pathway;Tyrosine;Work

PROJECT_TITLE: Aromatic Amino Acids, Microbiome-Generated Metabolites, and Incident Subclinical and Clinical CVD and Mortality

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Genetic Testing;Genetics;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

ORG_STATE: PA

PHR: PROJECT NARRATIVE: In 2010, more than 1 million infants born preterm (at less than 37 weeks of gestation) died worldwide, making it the second leading cause of death in children under the age of 5 years. The overarching goals of this study are to develop blood tests for both the early detection and ongoing prediction of pregnancy complications that result in preterm birth (PTB). The proposed study will improve our understanding of the biology of preterm birth and lead to the development of new diagnostic/screening tools to help us identify women at high risk of preterm birth for whom an intervention may be tested and for whom intervention is most critically needed.

PI_NAMEs: PETERS, DAVID GERARD (contact);SIMHAN, HYAGRIV N

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: 37 weeks gestation;5 year old;Affect;analytical method;analytical tool;Aneuploidy;Biology;Blindness;Blood Tests;Cause of Death;cell free DNA;Child;Chronic;Chronic Disease;Chronic lung disease;Clinical;clinical diagnosis;Clinical Management;clinical predictive model;clinical predictors;cognitive disability;Complex;Consensus;Country;Data;deafness;Developing Countries;Development;Diagnosis;Diagnostic;Discipline of obstetrics;Disease;DNA;DNA Methylation;Early Diagnosis;epigenomics;Etiology;Event;Expectancy;experience;fetal;Fetal Growth Retardation;Fetal Tissues;Fetus;Goals;High Risk Woman;High-Risk Pregnancy;human disease;Hypertension;improved;Incidence;Individual;Infant;Inflammation;Intervention;Learning Disabilities;liquid biopsy;Medical;Membrane;Methods;Methylation;methylomics;microdeletion;Modeling;Modernization;molecular phenotype;Newly Diagnosed;noninvasive diagnosis;novel diagnostics;Outcome;Pathologic;Pathway interactions;Patients;Pattern;Phenotype;Placenta;Plasma;post pregnancy;Pre-Eclampsia;predictive modeling;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnancy hypertension;Pregnant Women;Premature Birth;Premature Infant;Premature Labor;Prenatal care;prenatal testing;Principal Investigator;Process;programs;prospective test;Risk;Rupture;Sampling;screening;Screening procedure;standard of care;Statistical Models;Stratification;Syndrome;Testing;Time;Tissues;tool;United States;Visual impairment;Woman;Work

PROJECT_TITLE: Development of Non-invasive Liquid Biopsy Screening Tool for Preterm Birth Causes and Consequences

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Transplantation;Wound Healing and Care

PHR: Project Narrative Valvular heart disease affects over 2.5% of the US population. While transcatheter valve interventions can substantially decrease patient risk in comparison to open surgery, existing catheters do not provide the capability to easily cut or remove diseased valve tissue as is done during open surgery. The goal of this project is to increase patient eligibility and to enhance the accessibility of transcatheter valve repair by developing easy-to-use catheter technology for cutting diseased valve tissue during valve replacement.

PI_NAMEs: DUPONT, PIERRE E (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Ablation;Acute;Address;Adoption;Affect;Algorithm Design;Anatomy;Anterior;Aorta;aortic valve;aortic valve replacement;artery occlusion;base;Bioprosthesis device;Blood flow;calcification;Cardiopulmonary Bypass;Cardioscopes;Catheters;Complex;Consumption;Coronary;Coronary artery;Coronary Artery Bypass;Coronary Occlusions;Data;Death Rate;design;Development;Device Removal;Devices;Disease;Early Intervention;Electrosurgery;Eligibility Determination;Embolism;Emergency Situation;Excision;Exclusion;Femur;Frequencies;Future;Goals;Health;Heart Valve Diseases;Hospital Mortality;implantable device;in vivo evaluation;Incidence;innovation;Intervention;Laceration;Lasers;Left;Location;Methods;Mitral Valve;mitral valve replacement;Modification;mortality;Obstruction;Operative Surgical Procedures;optical fiber;Optics;Patient imaging;patient population;Patient risk;Patients;percutaneous coronary intervention;Performance;Physiologic pulse;Population;prevent;Procedures;Process;Prosthesis;Qualifying;Radial;Recovery;repaired;Research;Risk;Surface;Surgical Valves;System;Techniques;Technology;Thick;Time;Tissues;tool;valve replacement;Ventricular;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: Simple and Effective Laceration of Potentially-calcified Leaflets as an Adjunct to Transcatheter Valve Replacement

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ORG_CITY: CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative Progressive weight loss has been frequently associated with cancer progression with approximately 50-80% of patients developing this condition. This application seeks to identify the mechanisms that trigger cachexia and explore therapeutic opportunities to reverse this chronic condition in the context of cancer.

PI_NAMEs: IRUELA-ARISPE, M. LUISA  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: absorption;Address;Affect;Atrophic;Blood capillaries;Blood Vessels;Body Weight;Body Weight decreased;Cachexia;Cancer Cachexia;Cancer Etiology;Cancer Patient;cancer therapy;carcinogenesis;Carcinoma;Cells;Cessation of life;Chronic;Clinical;Compensation;Complex;cytokine;Data;design;Development;dietary;Dietary Intervention;Distant;Early Diagnosis;effective therapy;efficacy evaluation;Endothelial Cells;Endothelium;Etiology;Evaluation;experimental study;extracellular vesicles;Failure to Thrive;Fibrosis;Food;food consumption;Functional disorder;Genetically Engineered Mouse;Goals;Greater sac of peritoneum;Growth;Impairment;Implant;improved;Individual;Inflammation;Inflammatory;innovation;Intercellular Junctions;Intervention;Intervention Trial;intestinal villi;Intestines;KDR gene;Knowledge;lacteal;Lipids;Liquid substance;Location;Lymphatic;lymphatic dysfunction;Lymphatic Endothelium;Lymphatic function;lymphatic vessel;Malabsorption Syndromes;Malignant Neoplasms;MAP3K7 gene;Measurable;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Molecular;mouse model;Mus;Muscle;muscle form;Neoplasm Metastasis;Nodule;Normal tissue morphology;Organ;Patients;Phenotype;Phosphorylation;preclinical trial;prevent;Proteolysis;Quality of life;Recovery;reduced food intake;Regulation;repaired;Research Personnel;response;Risk;sarcopenia;Signal Pathway;Signal Transduction;Site;Skeletal Muscle;Skin;subcutaneous;Survival Rate;Testing;Therapeutic;therapeutic evaluation;Time;trafficking;Treatment Efficacy;treatment response;tumor;Tumor Burden;tumor progression;Tumor stage;Tumor-Derived;Vascular Endothelium;Vascular Permeabilities;Villus;Weight

PROJECT_TITLE: Rewiring Cancer-Induced Abnormalities in the Vascular Barrier


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative Across the state of Maryland, communities of color and low wealth populations are differentially burdened by environmental hazards and the cumulative impacts of chemical and non-chemical stressors and structural factors including pathogenic infrastructure that produce environmental health disparities (i.e., environmental injustice). To better identify and characterize environmental justice (EJ) communities, we plan to update Maryland Environmental Justice Screen (MD EJSCREEN), an environmental justice screening and mapping (EJSM) tool by the integration of air quality data and use of mixed methods approach- stakeholder feedback through focus groups and interviews and advanced statistical and geostatistical methods. This project is relevant to public health because it may: (1) help track disparities in air pollution exposure; (2) improve our capacity to track cumulative impacts of chemical and non-chemical stressors; (3) better visualize and track exposure-disease associations including health disparities at the neighborhood level; and (4) assist with microtargeting high risk areas that need mitigation strategies and investments to eliminate environmental injustice and improve public health.

PI_NAMEs: WILSON, SACOBY MIGUEL (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Address;Air;Air Pollution;Area;Biometry;Censuses;Chemicals;Climate;climate change;climate impact;coarse particles;Color;Communities;community center;community engagement;cost;Data;data platform;Decision Making;Development;Discrimination;Disease;Disparity;Economics;Environmental Hazards;environmental health disparity;environmental justice;Equity;experience;Exposure to;Feedback;fine particles;Focus Groups;Geography;Growth;Health;health disparity;high risk;improved;indexing;Individual;Inequity;Information Sciences;Infrastructure;innovation;Intervention;Interview;Investments;Justice;Lived experience;Maps;Maryland;Measures;meetings;Methodology;Methods;Modeling;Monitor;National Institute of Environmental Health Sciences;Natural Resources;Neighborhoods;Nitrogen Dioxide;novel;Outcome;Ozone;Pathogenicity;pollutant;Pollution;Population;Public Health;Qualitative Methods;racism;Readiness;Recovery;resilience;Resolution;response;Risk;screening;Screening procedure;segregation;sensor;social;sociodemographics;Statistical Data Interpretation;Strategic Planning;stressor;structural determinants;Structural Racism;System;Time;tool;Update;Visualization;Vulnerable Populations;Work

PROJECT_TITLE: Maryland EJSCREEN 4.0: Integration of Cumulative Impacts, Structural Racism and Discrimination, and Air Quality to Better Visualize and Assess Environmental Health Disparities

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LOS ANGELES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Relevance to public health: Differences in genome sequence underlie susceptibility to virtually every human disease, and predicting the effects of specific sequence differences is a crucial step in improving diagnosis, prevention, and treatment. Such predictions are currently challenging for differences that lead to changes in proteins, and all but impossible for differences that may instead alter the abundance of proteins. The proposed research will enable development of more accurate predictive models of the effects on health of all types of sequence sequence differences with currently unclear significance, leading to better diagnostic precision.

PI_NAMEs: KRUGLYAK, LEONID  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Agriculture;artificial intelligence model;Bar Codes;Biological;Biological Assay;Biological Models;Biomedical Research;Catalogs;causal variant;Cells;Chromosome Mapping;Code;Communities;Complex;CRISPR/Cas technology;Data;Data Set;design;Development;Diagnosis;diagnostic accuracy;disease diagnosis;DNA;DNA Sequence;Engineering;Ensure;Experimental Designs;feature selection;fitness;Frequencies;Gene Frequency;Genes;genetic manipulation;genetic variant;Genetic Variation;Genome;genome sequencing;genome-wide;genomic locus;Genomics;Genotype;Goals;Guide RNA;Haploidy;Health;High-Throughput Nucleotide Sequencing;Human;human disease;improved;Individual;interest;large datasets;large scale data;Libraries;Location;Machine Learning;Maps;Massive Parallel Sequencing;Measures;Medical;Modeling;Nonhomologous DNA End Joining;Oligonucleotides;Organism;Patients;Performance;performance tests;personalized diagnostics;Phenotype;Plasmids;Population;predictive modeling;Predisposition;Prevention;Proteins;Public Health;rare variant;repaired;Reproducibility;Research;Resolution;Saccharomyces cerevisiae;Sample Size;Sampling;scale up;single cell sequencing;single-cell RNA sequencing;Site;Statistical Methods;success;System;Testing;Time;tool;Training;trait;Transcript;Untranslated RNA;Validation;Variant;variant of unknown significance;virtual;yeast genetics;Yeasts

PROJECT_TITLE: High-throughput experimental determination and computational prediction of variant effects in yeast

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Nonalcoholic steatohepatitis (NASH) affects up to 12% of the United States population and lacks any effective therapies. We and others have recently generated compelling evidence that low doses of the commercially available generic drug digoxin can reduce steatosis, inflammation, and fibrosis in several murine models of NASH, and can reduce inflammation in healthy human subjects. The proposed research to ascertain that digoxin improves human NASH will be transformative in providing care for this patient population and of significant relevance to public health; it will also be pertinent to NIH’s mission of fostering innovative research strategies and their applications as a basis for ultimately improving health.

PI_NAMEs: BANINI, BUBU AMA (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: acute liver injury;Affect;Aftercare;Alcoholic Hepatitis;Anti-Inflammatory Agents;Antigen-Antibody Complex;Area;Binding;Biopsy;Cardiac;Cardiac Glycosides;Caring;CCL2 gene;CCL20 gene;Cell Differentiation process;Cells;Cholesterol;chronic liver disease;chronic liver injury;Cirrhosis;Clinic;Clinical;clinical practice;Clinical Trials;clinically relevant;CXCL1 gene;CXCL10 gene;cytokine;Data;Development;Digoxin;Dose;Double-Blind Method;Drug Industry;Economics;effective therapy;end stage liver disease;Enzyme-Linked Immunosorbent Assay;Epidemic;Fatty Liver;Fibrosis;Flow Cytometry;Fostering;Generic Drugs;Genes;Genetic Transcription;Goals;Granzyme;Health;healthy volunteer;heart function;Hepatic;Hepatic Stellate Cell;Hepatocyte;hepatoprotective;Human;human model;human subject;Hypoxia Inducible Factor;Immune;Immune response;Immunobiology;Immunohistochemistry;Immunologic Stimulation;immunoregulation;improved;In Vitro;in vitro Assay;Inflammation;Inflammatory;innovation;Interdisciplinary Study;Interleukin-10;Interleukin-6;Investigation;K ATPase;Lipopolysaccharides;Liver;liver biopsy;Liver Cirrhosis;Liver Fibrosis;liver inflammation;Macrophage;Malignant neoplasm of liver;Mediating;Mission;monocyte;Mortality Determinants;mouse model;Mus;Myelogenous;Myeloid Cells;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel therapeutics;Nuclear;Oral;patient population;Patients;peripheral blood;Peripheral Blood Lymphocyte;Pharmaceutical Preparations;Physical Examination;Placebo Control;Placebos;Plasma;Platelet-Derived Growth Factor;Population;prevent;primary endpoint;Production;Public Health;Publishing;Pyruvate Kinase;Quality of life;Randomized;Reporting;Research;response;Role;Safety;safety assessment;Serum;side effect;Stains;Steatohepatitis;Surveys;T-Lymphocyte;Target Populations;Testing;Therapeutic;Time;Tissues;Titrations;TNF gene;transcription factor;Transcriptional Activation;transcriptome sequencing;Translations;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Oral digoxin for the treatment of NASH

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Genetic Testing;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: INDIANAPOLIS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Alzheimer’s Disease (AD) is a complex, heritable brain disorder without known effective treatment. The proposed methods and tools will have considerable potential for discovery of genetic biomarkers to help monitor the disease progression and provide insights of downstream molecular mechanism toward the development of Alzheimer’s disease. These results can help with candidate screening in clinical trials and provide stratified risk groups to facilitate the development of therapeutic intervention.

PI_NAMEs: WANG, XIAOQIAN ;YAN, JINGWEN  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: abeta deposition;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid;Beds;biobank;Biological;Biological Markers;Brain;Brain Diseases;Brain imaging;Cells;Cerebrospinal Fluid;Classification;Clinical;clinical trial recruitment;Clinical Trials;cohort;Complex;Data;data modalities;deep ocean;Detection;Development;Diagnosis;Disease;Disease Progression;DNA;early detection biomarkers;Early Diagnosis;early screening;effective therapy;Etiology;Evolution;follow-up;Gene Expression;Gene Proteins;Genes;Genetic;Genetic Identity;Genetic Markers;Genetic Variation;Genotype;Genotype-Tissue Expression Project;Goals;graph neural network;Heritability;Heterogeneity;Image;imaging biomarker;Impairment;improved;Individual;individual variation;infancy;insight;Learning;Magnetic Resonance Imaging;Methods;Modality;Modeling;Molecular;molecular marker;Monitor;multimodality;Multiomic Data;multiple omics;multitask;Nerve Degeneration;Nervous System Trauma;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;novel;Outcome;Pathologic;Pathology;Pattern;Phase;Phenotype;phenotypic biomarker;Positioning Attribute;Positron-Emission Tomography;preservation;protein expression;Proteins;Proteome;Quantitative Trait Loci;Resources;Risk;Risk Factors;risk stratification;Sample Size;Scheme;screening;serial imaging;Severities;Shapes;Staging;Structure;Subgroup;Symptoms;Syndrome;tau Proteins;Testing;therapeutic development;Therapeutic Intervention;tool;transcriptome;transfer learning;Trees;Visit

PROJECT_TITLE: Characterizing the progression of Alzheimer's disease with multi-omic genetic and imaging data

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Lymphatic Research;Lymphoma;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This proposal will improve the automatic analysis of longitudinal, multi-time point PET/CT images of lymphoma by developing contextually-aware and multimodal vision-language deep learning algorithms. Quantitative PET metrics are highly predictive of outcome for lymphoma and could be used to improve the efficacy of PET-adapted therapy, but quantification of whole-body PET/CT images is time consuming and automated analysis of interim- therapy images is technically challenging. This project will address these challenges by designing and validating deep learning PET analysis algorithms that can simultaneously consider baseline and interim PET scans, thus mimicking the processes used by physicians, and also by designing semi-supervised multimodal algorithms that can use the information in radiology narrative reports for enhanced image analysis.

PI_NAMEs: BRADSHAW, TYLER J (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;Address;Adult;Algorithmic Analysis;Algorithms;automated algorithm;automated analysis;Awareness;Biological Response Modifier Therapy;Childhood;Childhood Hodgkin's Lymphoma;Clinical;clinical care;Clinical Trials;Complex;Consumption;cost;Data;Data Set;deep learning;deep learning algorithm;deep learning model;Dependence;design;Detection;Development;Diagnosis;diagnostic accuracy;Disease;Disease-Free Survival;diverse data;Evaluation;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Future;Goals;health record;Hodgkin Disease;Image;Image Analysis;Image Enhancement;imaging biomarker;improved;Inflammatory;Institution;Interobserver Variability;Knowledge;Label;Language;Learning;Lesion;longitudinal analysis;longitudinal positron emission tomography;Lymphoma;Measures;Methods;Modeling;multimodal learning;multimodal modeling;multimodality;multiple datasets;Non-Hodgkin's Lymphoma;Outcome;outcome prediction;Patient Care;patient health information;Patient-Focused Outcomes;Patients;Performance;Phase III Clinical Trials;phase III trial;Physicians;Physiological;Positron-Emission Tomography;predict clinical outcome;predicting response;predictive marker;Process;prognostic value;Radiologic Finding;radiologist;Radiology Specialty;Reading;Recording of previous events;Reporting;Residual state;response;Scanning;serial imaging;Site;standard of care;supervised learning;Technology;Text;Time;tool;Training;treatment strategy;uptake;Vision;Visual;X-Ray Computed Tomography

PROJECT_TITLE: Multimodal Learning for Contextually-Aware Longitudinal PET/CT image analysis

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Prevention

ORG_CITY: CORVALLIS

ORG_DEPT: CHEMISTRY

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The service life of dental composite restorations is estimated to be about 10 years, with replacement mainly due to recurrent caries caused by bacterial biofilms forming at the margins and within interfacial gaps. The proposed project will design and develop new divalent metal ions releasing dental materials to promote the oral microbiome diversity and extend the longevity of dental restorative materials, thus contributing to the NIH's aim of advancing human health through fundamental research.

PI_NAMEs: KOLEY, DIPANKAR  (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: Address;Adhesions;AlamarBlue;antimicrobial;Attention;Bacteria;Behavior;Biological;Biological Assay;biomaterial compatibility;Buffers;Cells;Chemicals;Clinical;clinically relevant;Complex;Composite Resins;composite restoration;Confocal Microscopy;Coupled;cytotoxicity;Data;Dental;Dental caries;Dental Materials;Dental Plaque;Dental Pulp;design;Development;Devices;Diffusion;divalent metal;effectiveness evaluation;effectiveness testing;electric impedance;Environment;Evaluation;Excision;Exposure to;Failure;Filler;Formulation;Foundations;fundamental research;Future;Glass;Growth;Hardness;Health;Human;human subject;Hydrogen Peroxide;improved;In Situ;In Vitro;in vitro Model;in vivo;in vivo evaluation;innovation;interfacial;Ions;Kinetics;Lactic acid;Life;Longevity;Measurable;Measurement;Measures;Mechanics;Metabolic;Metals;meter;microbial;Microbial Biofilms;microbial colonization;microbiome;microbiome alteration;Microscopic;Microscopy;microsensor;Modeling;novel;Nutrient;oral biofilm;Oral cavity;oral microbiome;organic acid;Performance;Persons;Plant Resins;polymicrobial biofilm;Population;Predisposition;prevent;Recurrence;Reproducibility;Research;Resolution;restoration;restorative dentistry;restorative material;Root Caries;Saliva;Scanning;sensor;Services;Specimen;Surface;Techniques;Testing;Time;Tooth Demineralization;Tooth structure;Undifferentiated;United States National Institutes of Health;volunteer;Width

PROJECT_TITLE: Microenvironmental characterization and manipulation to prevent secondary caries

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ODCS-K (90)]


ADMINISTERING_IC: MH

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE  As the most numerous non-neuronal cell types in the mammalian brain, astrocytes are proposed to regulate neuronal function via intracellular Ca2+-dependent signaling, which becomes deranged in numerous neurological and psychiatric disorders. The goal of this project is to elucidate the contribution of astrocyte Ca2+ signaling to the prefrontal neural circuit function and avoidance behavior. The proposed research is highly relevant to a broad range of mental disorders and may guide the development of innovative treatment.

PI_NAMEs: YU, XINZHU  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Action Potentials;Acute;Address;Affect;Animal Behavior;Anxiety Disorders;Area;Astrocytes;Attenuated;Aversive Stimulus;avoidance behavior;Behavior;behavior test;Behavioral;Blood Vessels;Brain;Brain Diseases;cell type;Cells;Central Nervous System;Characteristics;Color;Communication;Complex;Confocal Microscopy;Data;Development;Disease;Emotions;experimental study;Fiber;Fostering;gamma-Aminobutyric Acid;Genetic;genetic approach;genetic manipulation;Genetic Techniques;Glutamates;Goals;Heterogeneity;Human;Image;Impairment;in vivo;infancy;innovation;insight;intercellular communication;Investigation;Link;Medial;Mediating;Memory;Mental disorders;microendoscope;Modeling;Monitor;Mus;Nervous System Disorder;neural;neural circuit;neurobiological mechanism;Neuroglia;Neurons;neuropsychiatric disorder;Neurosciences;novel;novel therapeutics;optogenetics;Pathway interactions;Patients;pharmacologic;Photometry;Physiological;Physiology;Play;Population;Prefrontal Cortex;Process;receptor;Regulation;Reporting;Research;response;Rodent;Role;Series;Signal Transduction;Slice;spatiotemporal;Synapses;Testing;tool;Transgenic Mice;Work

PROJECT_TITLE: Astrocytic regulation of prefrontal neural circuits and avoidance behavior

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Disease;Organ Transplantation;Transplantation

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE End stage liver disease accounts for nearly 80,000 deaths a year in the United States, and we have less than 6,000 donor livers of adequate quality for transplantation. Increasing numbers of donor livers are discarded due to fatty liver disease because of the danger of post-transplant failure, and this clinical trial will use normothermic perfusion to assess and improve the quality of fatty livers to allow them to be safely transplanted. We will also develop new techniques to accurately assess the safety and transplantability of donor livers, as well as identify potentially therapeutic targets for intervention during normothermic machine perfusion.

PI_NAMEs: YEH, HEIDI  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Address;Admission activity;Adoption;Adverse effects;Allografting;Blood Vessels;care costs;Case Series;Cessation of life;Circulation;Clinical;clinical research site;Clinical Trials;cost;Cost Analysis;Cryopreservation;Data;Defect;Disease;Donor person;economic evaluation;end stage liver disease;experience;experimental group;Failure;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Financial Hardship;Functional disorder;graft failure;Graft Survival;Health;Hepatocyte;Hospitals;Impairment;improved;Incidence;indexing;Infiltration;insight;Intervention;Ischemia;ischemic injury;lipidomics;Liver;liver function;liver transplantation;meetings;metabolomics;Mission;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;Organ;Organ Donor;Outcome;oxidative damage;Pathway interactions;Patients;Perfusion;Pilot Projects;post-transplant;pre-clinical;preclinical study;Prevalence;Prevention;primary endpoint;Publishing;Recovery;Renal Replacement Therapy;Reperfusion Injury;Reporting;Research;response;Risk Factors;safety assessment;secondary endpoint;Serum Markers;Severities;success;Techniques;Technology;therapeutic target;therapy design;Time;transcriptomics;transplant centers;Transplantation;United States;Waiting Lists

PROJECT_TITLE: Normothermic perfusion of steatotic livers for transplantation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (04)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

PHR: NARRATIVE This proposal will develop novel methods using expansion microscopy to characterize the three- dimensional structure of the genome. These methods will reveal the spatial organization of different regulatory interactions in the genome with near nucleosome resolution, with the goal of understanding how different parts of the genome interact to regulate gene expression.

PI_NAMEs: BEWERSDORF, JOERG ;GIRALDEZ, ANTONIO J (contact);WANG, SIYUAN

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: 3-Dimensional;Address;Architecture;Bar Codes;Benchmarking;Biological Process;Cells;Cellular biology;Chromatin;chromatin protein;Chromatin Structure;Communities;Competence;Development;Disease;DNA;DNA Sequence;Enhancers;Epigenetic Process;epigenome;Equipment;experimental study;Fluorescent in Situ Hybridization;fluorophore;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;genetic variant;Genome;genome analysis;genome-wide;genome-wide analysis;genomic locus;Genomics;Goals;Hi-C;Histones;Homeostasis;Human;Image;imaging approach;imaging modality;improved;In Situ;Individual;insight;interest;Label;Link;Location;Measures;Metabolic;Methods;Microscopy;Modification;multimodality;nanometer resolution;nanoscale;novel;novel strategies;Nuclear;Nucleosomes;Organelles;Outcome;Population;Positioning Attribute;promoter;Proteins;Regulatory Element;Research;Research Personnel;Resolution;RNA;Role;Site;Structure;Structure-Activity Relationship;superresolution imaging;superresolution microscopy;Techniques;Testing;three dimensional structure;Three-dimensional analysis;Tissues;tool;trait;transcription factor;Transcriptional Activation;Visualization;whole genome;Work

PROJECT_TITLE: Multimodal Analysis of the Genome Architecture Using Expansion Microscopy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (80)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: CENTRE FOR ADDICTION AND MENTAL HEALTH

ORG_STATE: ON

PHR: PROJECT NARRATIVE A core symptom of body dysmorphic disorder (BDD) is perceptual distortions for appearance, which contributes to poor insight and delusionality, limits engagement in treatment, and puts individuals at risk for relapse. Results from this revised study, adding a body processing experiment to the existing face processing experiments, will provide a more comprehensive understanding of factors accounting for a broad range of appearance concerns in BDD. This will lay the groundwork for next-step translational perceptual retraining approaches to address face and body perceptual distortions.

PI_NAMEs: FEUSNER, JAMIE  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Anxiety;Appearance;Arousal;Attention;Behavior;Behavioral;Belief;biomarker discovery;Body Dysmorphic Disorder;Body Image;Body part;Body Size;Brain;Chest;clinical predictive model;Compulsive Behavior;convict;Data;digital;Dimensions;Disease;dorsal visual stream;emotion regulation;Emotional;experimental study;explainable machine learning;Eye;Eye Movements;Face;Face Processing;Functional Magnetic Resonance Imaging;gaze;General Population;Goals;Head;High Prevalence;Individual;inpatient psychiatric treatment;insight;Intervention;Investigation;Lobule;machine learning prediction;Measures;Mental Depression;Modeling;Motor;Motor Cortex;multisensory;Nature;Neck;neural;Neurobiology;neuroimaging;neuromechanism;neuroregulation;novel;Occupations;parent project;Parietal;Participant;Perception;Perceptual distortions;phenomenological models;Pilot Projects;Play;potential biomarker;precision medicine;Procedures;relapse risk;remediation;Research;Role;Saccades;Sampling;sensorimotor system;sensory integration;Severities;Shapes;Skin;Stimulus;Suicide attempt;Symptoms;System;Testing;Thigh structure;Thinking;tool;Training;Visual System;visual tracking

PROJECT_TITLE: Neural mechanisms of perceptual abnormalities and their malleability in bodydysmorphic disorder

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE In day-to-day life, we often flexibly select actions based on what we anticipate the outcomes will be. Stressors and adversities lead to failures in flexible goal seeking, causing organisms to defer to familiar, routinized behaviors that can contribute to compulsions, smoking, over-eating, and other health concerns. Our goal is to understand the learning and memory processes controlling action flexibility, and how they are disrupted by prolonged social isolation.

PI_NAMEs: GOURLEY, SHANNON LEIGH (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: adhesion receptor;Amygdaloid structure;Anatomy;Award;Behavior;Cell Adhesion;cell cortex;Cells;Chronic;compulsion;Dangerous Behavior;Dendritic Spines;Development;Disinhibition;Enterobacteria phage P1 Cre recombinase;Extracellular Matrix Proteins;Failure;flexibility;Food;Gene Expression;Gene Silencing;Gene Transfer;Genetic;genetic approach;Goals;Habits;Health;Hippocampus;Human;Hyperphagia;Immediate-Early Genes;improved;Integrins;Lead;Learning;Life;Mediating;Memory;memory encoding;memory process;memory retrieval;Mus;Nature;neglect;Nerve Growth Factor Receptors;Neurons;Operant Conditioning;Organism;Outcome;Pathologic;Pattern;Population;postsynaptic;prospective;Proteins;receptor;response;restraint;Retrieval;Rewards;Rho-associated kinase;Rodent;Signal Transduction;Site;Smoking;Social isolation;Source;Stress;stressor;System;Tamoxifen;Testing;therapeutic target;Time;tool;Training;Transgenic Mice;Vertebral column;Viral;Visualization

PROJECT_TITLE: Integrated mechanisms for orbitofrontal cortical control of memory and choice

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Visual cortical prostheses represent a promising treatment for patients with acquired blindness, but so far have these devices have used relatively simple strategies to deliver electrical stimulation to the visual cortex. This project will test whether use of stochastic variability in electrical stimulation pulse timing and amplitude, and use of electrical stimulation pulses precisely timed relative to ongoing alpha rhythms, can lead to better activation of visual pathways, and enhanced production of visual percepts. If effective these electrical stimulation strategies will lead to development of visual cortical prostheses that are safer and more effective, and could improve the performance of other brain computer interfaces.

PI_NAMEs: YOSHOR, DANIEL  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Accommodation phosphene;Acquired Blindness;Adult;Alpha Rhythm;Area;Award;Awareness;blind;Blindness;Brain;brain computer interface;Cerebral cortex;Charge;Clinical Trials;Communication;Computer software;Conscious;Data;design;Development;Device Safety;Devices;efficacy evaluation;Electric Stimulation;Electrodes;experimental study;Eye;Frequencies;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Future;Generations;Human;improved;information processing;innovation;interest;Left;Light;Longevity;Measurement;Measures;Methods;neural;neural circuit;novel;Optic Nerve;Patients;Pattern;Perception;Performance;Persons;Phase;Physiologic pulse;Production;Prosthesis;Protocols documentation;Quality of life;Reporting;Research;Research Personnel;Resolution;Retina;Safety;Spottings;System;Techniques;Technology;Testing;Time;Training;transmission process;Vision;vision development;Visual;Visual Cortex;visual information;Visual Pathways;Visual Perception;visual stimulus;Visually Impaired Persons;wireless

PROJECT_TITLE: Naturalistic electrical stimulation strategies for effective visual cortical prostheses

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Nanotechnology;Women's Health Research

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative-Relevance to Public Health We propose to develop a tumor cell and vasculature-targeted, cold-responsive nanotechnology-potentiated cryoimmunotherapy for treating both primary and metastatic cancer. This novel cancer therapy strategy may be invaluable for combating cancer metastasis and recurrence, which are the main causes of mortality in breast and many other types of cancer, to minimize the mortality and morbidity of cancer patients.

PI_NAMEs: HE, XIAOMING  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: 4T1;American;Binding;Blood;Blood Vessels;Breast;Breast Cancer Cell;breast cancer metastasis;cancer cell;Cancer Etiology;cancer immunotherapy;Cancer Patient;cancer recurrence;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;Cell Death;Cell division;Cells;Cessation of life;chemotherapy;Clinic;Clinical;cold temperature;Conventional Surgery;Cosmetics;Cryosurgery;Cytosol;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Dendritic Cells;Disseminated Malignant Neoplasm;Distant;Drug Delivery Systems;Drug usage;Encapsulated;Excision;Freezing;Frostbite;Gene Delivery;Heating;Hematologic Neoplasms;High temperature of physical object;Hour;hyperthermia treatment;Ice;Immune;immune cell infiltrate;Immune response;Immune system;Immunization;immunogenic cell death;Immunologics;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Literature;lymphoid organ;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Medical;Memory;Microtubule Stabilization;minimally invasive;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;Myeloid-derived suppressor cells;nanomaterials;nanoparticle;Nanotechnology;Nature;Neoplasm Metastasis;neoplastic cell;novel;Operative Surgical Procedures;Outcome;Paclitaxel;Pattern;Peripheral;Pharmaceutical Preparations;prevent;Primary Neoplasm;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;Public Health;receptor;Regulatory T-Lymphocyte;Reperfusion Therapy;Reporting;response;Safety;Shapes;Small Interfering RNA;Solid Neoplasm;success;T-Cell Activation;Temperature;Testing;Therapeutic;Time;time use;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Ultrasonography;Woman;Work

PROJECT_TITLE: Cold-responsive gene and drug delivery-potentiated cryoimmunotherapy

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Biotechnology;Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Genetics;Infectious Diseases;Lung;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE This application uses data from a large group of well-characterized subjects from the COPDGene Study, which includes 5 and 10 year follow-ups and extensive available genomics datasets. We will use the state-of-the-art Phage ImmunoPrecipitation Sequencing (PhIP-seq) technology to efficiently and comprehensively profile 3,000 blood samples for autoantibodies and antibodies from prior viral infections. We will determine whether infections with certain viruses and/or the development of specific autoantibodies are associated with more rapid progression of COPD.

PI_NAMEs: HERSH, CRAIG P;RUCZINSKI, INGO  (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Acceleration;Acute;adaptive immune response;adaptive immunity;Airway Disease;airway epithelium;Antibodies;Autoantibodies;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;Automobile Driving;autoreactivity;B-Lymphocytes;Bioinformatics;Biological Assay;Biometry;Blood specimen;CD8-Positive T-Lymphocytes;chest computed tomography;Chronic;Chronic Obstructive Pulmonary Disease;Clinical;clinical phenotype;Complement;Computational Biology;Coughing;Data;Data Set;Development;Disease;Disease Outcome;disease phenotype;Disease Progression;Epidemiology;Female;follow-up;Gene Expression;Genes;Genetic;genetic epidemiology;genomic data;Genotype;HLA Antigens;human virome;Immune;Immune response;improved;Infection;Inflammation;Inflammatory;Integration Host Factors;Interferons;Lead;Link;Lung CAT Scan;Lymphoid Follicle;Measures;Modeling;Molecular Immunology;Molecular Mimicry;Morbidity - disease rate;mortality;Mucous body substance;multidisciplinary;novel;novel strategies;Pathway interactions;peripheral blood;Phage ImmunoPrecipitation Sequencing;Plasma;Predisposition;Prevention;Production;Pulmonary Emphysema;pulmonary function;pulmonary function decline;Pulmonary function tests;Research;respiratory;respiratory virus;response;Risk Factors;Role;Sample Size;Sampling;Severity of illness;sex;Shortness of Breath;Symptoms;Technology;Testing;transcriptome sequencing;transcriptomics;vaccine acceptance;vaccine development;Variant;Viral;Viral Antibodies;Virus;Virus Diseases;Visit;Whole Blood;Woman;X-Ray Computed Tomography

PROJECT_TITLE: Defining the Role of Viral Infections and Autoantibodies in Chronic Obstructive Pulmonary Disease Progression


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics

ORG_CITY: RICHMOND

ORG_DEPT: BIOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: NARRATIVE The proposed study directly addresses one of the key challenges in the field of geroscience: What are the conserved mechanisms of longevity across evolutionarily divergent organisms? This proposal will address this question by analyzing the function of conserved essential genes in regulation of longevity. As a result we will reveal new aging genes and unknown components of conserved aging pathways with mechanistic framework that can be tested directly in mammalian systems and might ultimately lead to the development of new therapies to increase human healthspan.

PI_NAMEs: KAYA, ALAATTIN  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Address;Affect;age related;age related changes;Aging;aging gene;aging mechanism;aging process;Biogenesis;Biological Availability;Caenorhabditis elegans;Candidate Disease Gene;Cell Aging;Cell Physiology;Cells;Complex;Data;design;Development;dosage;Essential Genes;Eukaryota;Evolution;experimental study;extend lifespan;functional genomics;functional group;gene conservation;Gene Dosage;Gene Expression;gene function;Genes;Genetic;Genetic Epistasis;genetic testing;Genetic Transcription;genome-wide;Geroscience;Goals;healthspan;healthy aging;Homologous Gene;Human;Human Resources;insight;Invertebrates;knockout gene;Life;life span;Longevity;longevity gene;Longevity Pathway;Maps;Measurement;Mediating;Molecular;molecular phenotype;mRNA Expression;mRNA Surveillance;multicatalytic endopeptidase complex;Nematoda;novel strategies;novel therapeutics;Organism;Orthologous Gene;overexpression;Pathway interactions;Pattern;Persons;Pharmacologic Substance;Phenotype;Play;proteostasis;proteostasis loss;rate of aging;Regulation;RNA Interference;Role;screening;Signal Pathway;skills;Source;stem;System;Testing;tool;transcriptome sequencing;Translations;Validation;Yeasts

PROJECT_TITLE: UNDERSTANDING OF ESSENTIAL GENE FUNCTION IN AGING

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE STATEMENT One in nine women is expected to develop breast cancer during her lifetime, and 1 in 27 will die of it. In our recent study, we have demonstrated success in treating BRCA1-mutant cancer cells with E3 ligase deficiency using a new therapeutic approach but currently there is no testing available to identify patients who have a loss of E3 ligase function BRCA1 variant. In this study, we propose to develop new biomarkers that will allow us to identify BRCA1 deficiency by examining the expression profile of the ubiquitination protein substrates of BRCA1 so that it can allow us to stratify patients that can be most benefit from our proposed treatment.

PI_NAMEs: KONG, KIMI Y (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: BARD1 gene;Benign;biological adaptation to stress;Biological Markers;brca gene;BRCA1 gene;BRCA1 Mutation;BRCA2 gene;Breast Cancer Patient;Breast Cancer Treatment;cancer cell;cancer risk;Cell Death;Cells;Cessation of life;Characteristics;Clinical;Clinical Management;Complex;Correlation Studies;cyclophilin B;Cyclosporine;Data;Dependence;Diagnosis;Disease;DNA Repair;efficacy study;Endoplasmic Reticulum;Endoplasmic Reticulum Degradation Pathway;Enzyme-Linked Immunosorbent Assay;Expression Profiling;Freezing;Gene Expression;Gene Mutation;Genes;Genetic Complementation Test;genetic information;Germ Lines;Hereditary Breast Carcinoma;homologous recombination deficiency;improved;In Vitro;in vivo;Induced Mutation;Inherited;Investigation;loss of function mutation;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Mediating;Methylation;Modeling;Molecular Chaperones;mutant;Mutation;novel therapeutic intervention;overexpression;Pathogenicity;patient screening;patient stratification;Patients;Pattern;PERK kinase;Phase II Clinical Trials;Phenotype;Phosphotransferases;Probability;prognostic model;promoter;protein expression;Proteins;proteostasis;public health relevance;Relapse;Reporting;Research;Resistance;response;response biomarker;Ribonucleases;Sampling;sensor;Signal Pathway;Stains;Stress;success;targeted treatment;Testing;Therapeutic;tumor;ubiquitin-protein ligase;Ubiquitination;Uncertainty;Variant;variant of unknown significance;Woman;Work

PROJECT_TITLE: Biomarkers For BRCA1-Deficient Cancers

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics;Human Genome;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BERKELEY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative White adipose tissue has a central role in maintaining whole-body metabolic health, thus it is critical to understand how adipocyte develops and how it remodels in response to high caloric diet. We propose that TET3 is a critical epigenetic regulator in homeostatic control of adipocyte development under chow-fed conditions and diet-induced adipose expansion. We address this question by using integrated physiological, genomic, and epigenomic profiling, and targeted epigenetic editing approaches on a newly-developed APC-specific Tet3 KO mice.

PI_NAMEs: KANG, SONA  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: 3-Dimensional;Address;adipocyte differentiation;Adipocytes;Adipose tissue;Adult;Affect;ATAC-seq;Biological Assay;Biology;blood glucose regulation;Brown Fat;Cells;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;conditional knockout;demethylation;Development;Diet;DNA;DNA Methylation;DNA methylation profiling;Embryo;Enzymes;Epigenetic Process;epigenetic regulation;epigenomic profiling;epigenomics;extracellular;Fibrosis;Funding;gain of function;Gene Expression;Genes;Genetic Transcription;genomic profiling;Genomics;Glucose Intolerance;Goals;Health;High Fat Diet;Homeostasis;improved;in vivo;Inflammation;Insulin Resistance;insulin sensitivity;Knockout Mice;lipid biosynthesis;loss of function;Mediating;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolism;Methylation;methylome;Modeling;Morphology;mouse genetics;mouse model;multiple omics;Mus;new therapeutic target;NFIX gene;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Obesity;Phenotype;Physiological;Play;PPAR gamma;precursor cell;prevent;Process;Regulation;Regulatory Element;Reporter;response;Role;single-cell RNA sequencing;Site;Specificity;Testing;transcription factor;transcriptomics;Transplantation

PROJECT_TITLE: Epigenetic regulation of adipose development and remodeling

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Pediatric;Substance Misuse;Women's Health Research

ORG_CITY: SPRINGFIELD

ORG_NAME: BAYSTATE MEDICAL CENTER, INC.

PHR: PROJECT NARRATIVE Mothers with substance use disorders face unprecedented stress in their roles as parents working to care for their children while maintaining healthy recovery. Mothering from the Inside Out (MIO) is the first attachment- based parenting intervention designed specifically for mothers in recovery from substance use disorders that has been shown to have bigenerational benefit in multiple randomized controlled trials. This project will: (a) test the effectiveness of MIO among women in outpatient addiction treatment under ‘real-world’ conditions, (b) further elucidate the MIO mechanism of change associated with improvements in caregiver behavior and maternal mental health outcomes, and (c) assess key implementation constructs to support optimal uptake and treatment in future dissemination studies; closing an important science-to-service gap for an underserved population in an effort to support maternal and child health simultaneously.

PI_NAMEs: PEACOCK-CHAMBERS, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: 5 year old;Acceleration;addiction;Address;Affect;attenuation;Behavior;Behavioral;Birth;Caregivers;caregiving;Caring;Cessation of life;Characteristics;Child;Child Care;Child Development;Child Rearing;Client;Climacteric;Clinic;Clinical;cohort;Communities;community academic partnership;community based treatment;community clinic;community partners;community setting;compare effectiveness;critical period;Data;depressive symptoms;Development;Dissemination and Implementation;Distress;Drug usage;Education;Effectiveness;effectiveness evaluation;effectiveness study;effectiveness testing;effectiveness/implementation study;effectiveness/implementation trial;efficacy trial;Emotional;Emotions;Enrollment;Ensure;Environment;evidence base;Evidence based practice;Exhibits;Face;follow-up;Future;General Population;Health;Health Personnel;Hybrids;implementation determinants;implementation evaluation;implementation outcomes;implementation process;implementation strategy;improved;Individual;Interruption;Massachusetts;Maternal and Child Health;maternal caregiving;maternal drug use;maternal outcome;Mediating;Mediator;Mental Health;Methodology;Methods;Mind;Modeling;mortality;Mother-Child Relations;Mothers;multidisciplinary;National Institute of Drug Abuse;offspring;organizational climate;Outcome;Outpatients;Overdose;parenting intervention;Parents;Pharmaceutical Preparations;Postpartum Period;Pregnancy;primary outcome;Problem behavior;Professional counselor;program dissemination;Public Health;Randomized;randomized effectiveness trial;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Recovery;recruit;reduced substance use;Relapse;Research;Research Personnel;Research Project Grants;Risk;Role;routine care;Science;secondary outcome;Security;service gap;Services;Site;Stress;substance use;Substance Use Disorder;substance use treatment;Testing;therapy design;Training;treatment as usual;treatment optimization;Treatment outcome;treatment program;Underserved Population;uptake;Woman

PROJECT_TITLE: A Type I Hybrid Effectiveness-Implementation Trial of "Mothering from the Inside Out" (MIO)

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Digestive Diseases;Neurosciences

ORG_CITY: RENO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Project Narrative Intrinsic and extrinsic nerves modulate movements of the GI tract, however the underlying patterning of GI motility depends upon intrinsic myogenic behaviors. The propulsive contractions of the colon (colonic migrating motor complexes or CMMC) are thought to be due to neurogenic motor patterns programmed within the myenteric plexus and direct innervation of smooth muscle cells. Recent work on this project has introduced important new information about how colonic motor activity is initiated and propagated. We are investigating mechanisms and functions of interstitial cells of Cajal (ICC) of which there are four classes in colonic muscles. These cells generate spontaneous, stochastic Ca2+ release events that activate Cl- channels (encoded by Ano1) in the plasma membrane, causing transmembrane inward currents. Neural inputs regulate Ca2+ signaling in ICC, thus modulating the myogenic drive on colonic motility. Loss or disabling of the basic functions of ICC (e.g. blocking Ca2+ signaling or ANO1 channels) causes defects in colonic motor activity, including decreased smooth muscle excitability, inhibition of phasic contractions, and disruption in major motility patterns, such as CMMCs. Because neural signals are transduced by ICC, damage to ICC makes it difficult or impossible to restore colonic motility by enhanced neural output. In the next funding period mechanisms responsible for Ca2+ transients in colonic ICC-MY and regulation of these events by enteric motor neurons will be characterized. Integration of activity between smooth muscle cells and ICC will be studied, and mechanisms responsible for initiation and propagation of propulsive contractions will be clarified. Animal models of ICC loss will also be characterized to develop new tools for testing therapeutics for motility disorders associated with ICC loss (e.g. slow transit constipation).

PI_NAMEs: BAKER, SAL  (contact);SANDERS, KENTON M

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: 3-Dimensional;Address;Aging;Anatomy;Animal Model;Animals;Behavior;Cell membrane;Cell Shape;Cells;Characteristics;Colon;Comparative Study;confocal imaging;Consensus;Constipation;Cytoskeleton;Data;Defect;Diabetes Mellitus;Disabling;Distal;Electrophysiology (science);Enteral;Event;experimental study;Extracellular Matrix;Family;Funding;Gap Junctions;gastrointestinal;Gastrointestinal Motility;Gastrointestinal tract structure;Giant Cells;high resolution imaging;Human;Image;improved;In Situ;insight;Interstitial Cell of Cajal;Investigation;Knowledge;Learning;loss of function;Maintenance;Mediating;Membrane;Membrane Potentials;Migrating Myoelectric Complex;Modeling;Morphology;Motility;motility disorder;Motor;Motor Activity;Motor Neurons;mouse model;Movement;Mus;Muscle;mutant;Myenteric Plexus;Nerve;nerve supply;neural;neuromechanism;Neurons;neuroregulation;neurotransmission;Neurotransmitters;Normal Cell;novel;Obstruction;Operative Surgical Procedures;optogenetics;Organ;Outcome;Output;Pacemakers;Pathology;Patients;Pattern;Peristalsis;Phase;Physiology;Population;preclinical study;Publishing;receptor;Regulation;response;Role;sensor;Signal Transduction;Small Intestines;Smooth Muscle;Smooth Muscle Myocytes;Stomach;Stretching;Symptoms;Techniques;Testing;therapeutic evaluation;Time;Tissues;tool;Transgenic Organisms;Work

PROJECT_TITLE: Role of interstitial cells of Cajal in patterned colonic motor activity

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Human Genome

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE Aortic aneurysm is a life-threatening disease characterized by the dilation of the vessel wall due to loss of vascular integrity and dysfunction of resident cells. The studies of this proposal will investigate the causal relationship between modifications of aortic vascular cell’s extracellular environment and changes in cell genome organization and gene expression through processes called epigenetic mechanisms. The proposed studies will greatly enhance our understanding of the mechanisms regulating vascular cell behavior in aneurysm.

PI_NAMEs: GOMEZ, DELPHINE  (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: Actins;Actomyosin;Aneurysm;Aorta;Aortic Aneurysm;Area;Automobile Driving;beta Aminopropionitrile;Binding;biomechanical test;Biomechanics;Blood Vessels;cell behavior;Cell Culture System;cell dedifferentiation;Cell Differentiation process;Cell Lineage;Cell Nucleus;Cell Physiology;Cells;Cessation of life;Chromatin;chromatin remodeling;Consensus;Cytoskeleton;Data;Defect;demethylation;depolymerization;Disease;Dissection;Environment;Epigenetic Process;epigenetic regulation;epigenome editing;epigenomics;Etiology;Evolution;Experimental Models;extracellular;Extracellular Matrix;Extracellular Matrix Degradation;Focal Adhesions;Functional disorder;Gene Expression;gene repression;Genes;Genetic study;Genome;Genomics;histone modification;Homeostasis;Human;human model;In Vitro;in vivo Model;innovation;interdisciplinary approach;Knockout Mice;Life;loss of function;mechanical force;mechanotransduction;Medial;Mediating;Microfilaments;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Contraction;Mutation;novel;novel therapeutic intervention;Nuclear;Operative Surgical Procedures;Organizational Change;Pathogenesis;Pathway interactions;Patients;Phenotype;Play;premature;Prevention;Process;Property;prophylactic;protective pathway;protein complex;Proteins;Regulation;Repression;Risk Factors;Role;Rupture;Severity of illness;single-cell RNA sequencing;Smooth Muscle Myocytes;Specimen;Testing;Therapeutic;Thoracic Aortic Aneurysm;Tissues;Translating;transmission process;Tretinoin;Vascular Smooth Muscle;Vinculin;Writing

PROJECT_TITLE: Mechano-epigenetic disruption in aortic aneurysm

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Neurosciences

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Growing evidence shows that noise exposure and hearing loss induce profound changes in the central auditory system from brainstem to cortex and that dysfunction of ion channels, termed channelopathies, has been linked to many neurological disorders, including deafness and tinnitus. This project aims to study calcium permeable ion channels and their synaptic function, and how hearing loss affects these ion channels and synaptic properties. The research proposed here will establish a new view of the role of presynaptic calcium permeable channels in synaptic function and their role after injury, providing the basic groundwork for future strategies for the treatment of channelopathies and hearing disorders.

PI_NAMEs: HUANG, HAI  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Action Potentials;Affect;analog;Animal Model;ascorbate;Attenuated;Auditory;Auditory system;Brain;Brain Stem;Calcium;Cations;Chemical Synapse;Data;deafness;Dendrites;digital;Earplug;Exocytosis;Frequencies;Functional disorder;Future;Glutamates;Goals;Hearing;hearing impairment;Hearing problem;Hybrids;Image;Immunohistochemistry;information processing;Injury;insight;Ion Channel;Link;Maps;Mediating;Membrane Potentials;millisecond;mouse model;Mus;Nervous System Disorder;neural circuit;neuronal cell body;Neurons;neurotransmission;neurotransmitter release;noise exposure;Pathologic;Permeability;pharmacologic;Physiological;Physiological Processes;Physiology;postsynaptic;presynaptic;Presynaptic Terminals;Probability;Property;recruit;Recycling;Research;Rest;Role;Signal Transduction;Site;Sodium;sound frequency;Synapses;synaptic function;Synaptic Transmission;Synaptic Vesicles;Techniques;Tinnitus;tool;Transgenic Mice;treatment strategy;two-photon;uptake;Vesicle;voltage;Work

PROJECT_TITLE: Synaptic mechanisms of auditory information processing

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_CITY: PROVIDENCE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE Candida albicans is frequently found in the gastrointestinal (GI) tract where its presence is highly relevant to public health as it directs local and systemic immune responses, as well as has the potential to translocate out of this niche to cause life-threatening systemic infections. The research outlined here will provide detailed mechanistic information into how C. albicans is able to grow in the GI tract including competition with the repertoire of bacterial species found in this niche.

PI_NAMEs: BENNETT, RICHARD JOHN (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Adhesions;anti-fungal agents;Antibiotic Therapy;Antibiotics;Asthma;Attention;Bacteria;bacteriome;Bar Codes;Behavior;Biological Assay;Candida albicans;cell injury;Cell secretion;cell type;Cells;Custom;Data;Death Rate;Disease;Enabling Factors;Engineering;Environment;Epithelial Cells;Exclusion;Exhibits;experimental study;Filament;fitness;fungus;gastrointestinal;Gastrointestinal tract structure;Genes;Growth;gut colonization;Health;host colonization;Human;Hyphae;Immune response;Immunologic Stimulation;Infection;Inflammatory Bowel Diseases;insight;interest;Intestines;Intrinsic factor;Invaded;Life;Link;microbiota;Modeling;Morphology;mouse model;Mucous Membrane;Mus;Mycoses;novel;pathobiont;pathogenic fungus;Pathologic;Peptides;Play;Population;Production;programs;Property;Proteins;Public Health;Pulmonary Inflammation;Research;Role;Sepsis;Series;Spatial Distribution;Supplementation;Symbiosis;Systemic disease;Systemic infection;Techniques;Tissues;Toxin;transcription factor;Virulence;Yeasts

PROJECT_TITLE: C. albicans-intrinsic mechanisms defining gut colonization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IMII-U (01)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: BOSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative. Improper gene expression causes many diseases, including developmental defects and cancer. The goal of this project is to understand the fundamental processes by which genes are expressed and regulated. This understanding will be essential for designing treatments and drugs to restore normal gene expression in diseased cells or to alter gene expression patterns to create pluripotent stem cells and specific differentiated cell types.

PI_NAMEs: BURATOWSKI, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Affect;analysis pipeline;Antibodies;arm;Binding;Biochemical;Biological Assay;C-terminal;Cell Differentiation process;cell type;Cells;Characteristics;Chromatin;chromatin immunoprecipitation;chromatin modification;Chromatography;Collaborations;Color;Complex;Coupled;Coupling;Defect;Development;Disease;Dyes;Elongation Factor;Engineering;Enzymes;Event;experimental study;factor A;flexibility;Foundations;Funding;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic Techniques;Genetic Transcription;Genomics;Goals;HIV;Immobilization;improved;In Vitro;Individual;insight;Kinetics;Knowledge;Label;Location;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Medical;Messenger RNA;Methods;Methyltransferase;Microscopy;millisecond;Modeling;Modification;Molecular;Monitor;mRNA guanylyltransferase;Mutation;N-terminal;Nuclear Extract;Nucleosomes;Organism;Pattern;Pattern Recognition;Peptides;Pharmaceutical Preparations;Phenotype;Phospho-Specific Antibodies;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Plants;Pluripotent Stem Cells;Process;Productivity;Protein Binding Domain;Proteins;Radial;Resolution;RNA Polymerase II;RNA Processing;Series;single molecule;Specificity;stoichiometry;Structure;System;tat Protein;Techniques;Testing;therapy design;Thinking;Time;Total Internal Reflection Fluorescent;Transcript;Transcription Elongation;transcription factor;transcription factor TFIIH;Transcription Process;Untranslated RNA;Viral;Visualization;Work;Yeasts

PROJECT_TITLE: mRNA Capping Enzyme

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rehabilitation;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: SURGERY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Breast reconstruction is a critical part of comprehensive breast cancer treatment. Decisions about breast reconstruction would benefit from decision aids, which improve decision quality but are not often used. We propose to adapt a proven decision aid called BREASTChoice for use on mobile devices and to disseminate it widely by leveraging social media and online communities.

PI_NAMEs: LEE, CLARA NAN-HI (contact)

PROGRAM_OFFICER_NAME: EVERSON, NICOLE MARIE

PROJECT_TERMS: Adoption;Age;American;Appearance;Black race;Body Image;Breast Cancer Patient;Breast Cancer survivor;Breast Cancer Treatment;Cancer Survivor;Clinical;community partners;Complication;Conflict (Psychology);Data;Decision Aid;Decision Making;design;Diffusion of Innovation;digital;Effectiveness;effectiveness outcome;Electronic Health Record;Facebook;Family;Family member;Friends;handheld mobile device;Health;health care availability;Hispanic;Image;Impairment;implementation research;impression;improved;interest;Internet;Interruption;Intervention;Interview;Knowledge;Latina;Mammaplasty;Mastectomy;Media Campaign;Methods;Modeling;Modification;novel strategies;older adult;Older Population;online community;Operative Surgical Procedures;Participant;Patients;Persons;Phase;preference;Production;Quality of life;Randomized, Controlled Trials;Readiness;reconstruction;Recovery;Reporting;Risk;satisfaction;social media;Surveys;Testing;theories;Time Series Analysis;tool;Training;treatment choice;Twitter;Underserved Population;uptake;usability;web site;Woman

PROJECT_TITLE: Dissemination of a breast reconstruction decision tool through social media and online communities

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety

ORG_STATE: MD

PHR: Project Narrative  Removing membranes from the surface of the retina is among the most common vitreoretinal surgeries performed in the US. This delicate procedure can have a high incidence of intraoperative complications, that could benefit from the use of robotic assistance. Current limitations and challenges of robotic approaches include cumbersome setup, limited access to important portions of the retina, and lack of force feedback to the surgeon. To consistently enable human utilization of robotics in epiretinal membrane peeling, we propose to develop a novel system that will fuse tool-tissue force information with intraoperative guidance via a high-dexterity robotic assistant surgical platform with cooperative and teleoperated control.

PI_NAMEs: IORDACHITA, IULIAN IOAN (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Acceleration;Address;Biological;chicken egg;Clinical;Clinical Trials;Complication;Coupled;design;Development;dexterity;Diabetic Retinopathy;Disease;Distal;Epiretinal Membrane;Excision;Eye;Family suidae;force feedback;Forcep;Freedom;Goals;Grant;Hand;Human;Hybrids;Image;improved;in vivo;Incidence;Injury;innovation;instrument;Intraoperative Complications;Intuition;Laparoscopic Surgical Procedures;Lifting;macula;Macular Hole;Mechanics;Membrane;meter;Methods;Micromanipulation;microrobot;Microsurgery;minimally invasive;novel;Ocular Pathology;Operating Rooms;Operative Surgical Procedures;Ophthalmologic Surgical Procedures;Ophthalmologist;optical fiber;Patient Care;Patients;Positioning Attribute;Postoperative Complications;Procedures;Quality of life;Reproducibility;response;Retina;Robot;robot assistance;robotic system;Robotics;Safety;Scheme;sensor;Sensory Thresholds;Snakes;Surface;Surgeon;Surgical Instruments;System;Systems Integration;Tactile;Technology;teleoperation;Testing;Tissues;tool;Translations;Trauma;trend;Vitrectomy;Work

PROJECT_TITLE: Enabling Dexterous Intraocular Surgery with Robotic Assistance

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Infectious Diseases;Racial and Ethnic Minority Health Research

ORG_CITY: NEW YORK

ORG_DEPT: DENTISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Periodontitis is a chronic disease affecting millions of people globally and has complex underlying cellular and molecular drivers. Here, we aim to leverage a systems biology functional approach to dissect the cellular states driving periodontitis and the added burden of type 2 diabetes. We will characterize clinical samples by single-cell expression profiling, perform advanced computational analyses, and test regulators of cell state and signaling that may offer future novel therapeutic targets.

PI_NAMEs: MOMEN HERAVI, FATEMEH  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Affect;Anti-Inflammatory Agents;Apoptotic;Automobile Driving;Bioinformatics;Biological;Black Populations;Blood specimen;Cell Physiology;Cells;Chronic;Chronic Disease;Circulation;Clinical;college;Complex;Computer Analysis;Data Analyses;Dental;Disease;Disparity;Down-Regulation;Epigenetic Process;Event;Funding;Future;gain of function;Gene Expression;Genetic Transcription;Gingiva;Goals;health disparity;Health Services Accessibility;Heterogeneity;Immune;immune checkpoint;Immune Tolerance;Individual;Inflammation;Inflammatory;innovation;Label;Link;loss of function;low socioeconomic status;Macrophage;Macrophage Activation;Medicine;Metabolic;Methodology;Methods;microbial;Minority;Minority Groups;Molecular;Molecular Target;monocyte;Myelogenous;Myeloid Cells;Natural Immunity;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Pathogenesis;Pathway interactions;Patients;PD-1 pathway;PD-1/PD-L1;Periodontitis;peripheral blood;Persons;Phenotype;Play;Population Heterogeneity;Positioning Attribute;Predisposition;Prevalence;programmed cell death ligand 1;Race;racial minority population;recruit;Reporting;Resolution;Risk;Risk Factors;Role;Sampling;Severities;Signal Transduction;single-cell RNA sequencing;systemic inflammatory response;Systems Biology;Techniques;Testing;Therapeutic;Thinking;Tissue Sample;Tissues;Tooth Loss;transcriptomics;Translational Research;Universities;Work

PROJECT_TITLE: Single-cell RNA-sequencing for functional analysis of monocytes and macrophages in periodontitis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]