NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Neurosciences;Rare Diseases;Stomach Cancer

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: NARRATIVE Upon completion of the human genome project, there was immense expectation that the newly gained information would bring critical understanding as well as cure for diseases such as cancer. But the complexity of the genome revealed a huge chasm between measuring and understanding—joint interpretation of genomes and transcriptomes is a bottleneck to progress in medicine, where advances stagnate compared to advances in quantification and manipulation. We examine genomes in the context of the resource environment that surrounds their respective carrier cells, and aim to understand energetic contingencies for the evolution of resistance to cytotoxic therapies.

PI_NAMEs: ANDOR, NOEMI  (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Affect;Apoptosis;Brain Neoplasms;brain tissue;cancer cell;Cancer cell line;cancer type;Cell Death;Cell Energetics;Cell Line;Cell Proliferation;Cell Survival;Cells;chromosome missegregation;Chromosome Segregation;Chromosomes;Clinical;Coin;Computing Methodologies;cost;Cytotoxic Chemotherapy;Data;Diploidy;Disease;DNA;DNA Damage;DNA sequencing;Dose;Drug Monitoring;Drug Targeting;Endowment;Environment;Event;Evolution;expectation;experimental study;fitness;Fluorescence Microscopy;gastric cancer cell;Gastric Tissue;Generations;Genetic Materials;Genome;Genomic Segment;Genomics;Glioblastoma;Glucose;Growth;Haploidy;Human Genome Project;Image;imaging platform;in silico;In Vitro;in vivo;inorganic phosphate;Joints;Knowledge;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;malignant stomach neoplasm;mathematical methods;mathematical model;Measures;Medicine;Microtubules;migration;Mitotic;Modeling;neoplastic cell;Outcome;Oxygen;Parents;Patients;Pharmaceutical Preparations;Phase;Phenotype;Ploidies;Population;Population Heterogeneity;prevent;Process;Prognosis;programs;Proliferating;replication stress;Research;Resistance;Resources;response;Risk;Role;S phase;segregation;single cell sequencing;single-cell RNA sequencing;Somatic Cell;Spatial Distribution;Stomach;Stomach Neoplasms;Testing;Time;Tissues;transcriptome;translational potential;tumor;tumor DNA;tumor heterogeneity;tumor metabolism;Validation;Vinblastine

PROJECT_TITLE: Characterizing cytotoxic therapy induced shifts in the cost-to-benefit ratio of high ploidy

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Services;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE This proposal aims to develop innovative new methods to improve the clinical management of breast calcifications detected on screening mammograms. The proposed research is relevant to public health because it seeks to reduce the harms of mammography screening and to facilitate more personalized treatment planning for women diagnosed with early-stage breast cancer. The proposed research is relevant to the part of NIH’s mission that seeks to foster creative discoveries to improve health.

PI_NAMEs: GRIMM, LARS J (contact);RYSER, MARC

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Address;Appearance;Benign;Biological;Biological Markers;Biology;Biopsy;Breast;Breast Cancer Detection;breast lesion;calcification;Calibration;Cancer Biology;Classification;Clinical;clinical decision-making;Clinical Management;clinical practice;Clinical Trials;cohort;Computer Assisted;Computer Vision Systems;Creativeness;Data;Databases;Decision Making;Development;Diagnosis;Diagnostic;Diagnostic Imaging;Dimensions;Disease;Disease Progression;epigenetic clock;Evolution;Excision;Failure;follow-up;Fostering;Foundations;Goals;Growth;Harm Reduction;Health;Health Care Costs;Histopathology;Image;imaging biomarker;improved;In Situ Lesion;Indolent;infiltrating duct carcinoma;innovation;Joints;Lead;Lesion;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Mathematics;Measures;Methods;Mission;Modality;Modeling;Monitor;Morbidity - disease rate;multidisciplinary;neoplastic;Noninfiltrating Intraductal Carcinoma;Operative Surgical Procedures;Outcome;overtreatment;Pathology;Patient Monitoring;Patient risk;Patients;Pattern;Performance;personalized medicine;Practice Guidelines;predictive marker;Predictive Value;Prognosis;prognostic;prognostic model;prospective;psychological distress;Public Health;radiological imaging;radiologist;radiomics;Research;Resources;Risk;risk stratification;screening;screening guidelines;screening program;serial imaging;Surgical Oncology;Testing;Time;tissue biomarkers;Tissue Sample;Tissues;treatment planning;tumor;Uncertainty;United States;United States National Institutes of Health;Woman;women's diagnosis;Work

PROJECT_TITLE: Dynamic imaging and tissue biomarker models to delineate indolent from aggressive breast calcifications


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Adoptive T cell therapy, though promising, faces significant hurdles for the treatment of patients with solid tumors, including the need for conditioning chemotherapy. In mouse models, the investigators observed that T cells endowed with synthetic IL9 receptor signaling have great promise in the treatment of solid tumors even in the absence of conditioning chemotherapy. In this proposal, they will study how synthetic IL9R signaling rewires T cells for better anti-tumor effects, overcoming the need for conditioning chemotherapy.

PI_NAMEs: KALBASI, ANUSHA  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Address;Adoptive Cell Transfers;Adoptive Transfer;Antigens;antitumor effect;ATAC-seq;Automobile Driving;Binding;Biology;cancer therapy;Cells;Characteristics;chemotherapy;Chimera organism;chimeric antigen receptor;Chromatin;Chronic;conditioning;CTAG1 gene;cytokine;Cytokine Receptors;Data;draining lymph node;effector T cell;Endowment;engineered T cells;Epigenetic Process;exhaustion;Extracellular Domain;Face;Functional disorder;Gene Expression Profile;Genetic Transcription;Goals;Hematologic Neoplasms;Homing;Human;IL2 gene;IL4R gene;IL7R gene;IL9 gene;Immunotherapy;improved;In Vitro;in vivo;Infiltration;Interleukin 2 Receptor;Interleukin 2 Receptor Gamma;Interleukin-2;interleukin-21 receptor;lymph nodes;Maps;Memory;Modeling;mouse model;Mus;next generation;novel strategies;Patients;Peripheral;Phenotype;Phosphorylation;Positioning Attribute;prevent;programs;rational design;receptor;Receptor Signaling;Research Personnel;Resistance;Role;safety and feasibility;Series;Signal Transduction;Solid Neoplasm;stem cells;success;synthetic biology;T cell therapy;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Toxic effect;transcriptomics;Translating;translational therapeutics;transmission process;tumor

PROJECT_TITLE: Synthetic IL9R signaling to rewire T cells for adoptive cell therapy of cancer

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Neurodegenerative;Rare Diseases

ORG_CITY: NOTRE DAME

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative Amyotrophic lateral sclerosis (ALS) is a severe and deadly disease. The proposed research will contribute to our fundamental understanding of how these diseases result from proteins folding upon entering biological structures known as membrane-less organelles. The project will accomplish this by making the first real-time measurements of this process using vibrational spectroscopy and imaging.

PI_NAMEs: SERRANO, ARNALDO L (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;Alzheimer's Disease;Amyloid;Amyotrophic Lateral Sclerosis;Biological;Biophysical Process;Biophysics;Cells;Complex;Crowding;design;Disease;Disease Progression;driving force;Gel;Goals;Hydration status;Hydrogels;Image;In Situ;infrared microscopy;infrared spectroscopy;Liquid substance;Membrane;Microscopy;Non-Insulin-Dependent Diabetes Mellitus;Organelles;Peptides;Phase;Polymers;Process;programs;protein folding;protein structure;Proteins;Reporting;Research;Role;Secondary Protein Structure;Spectrum Analysis;Structure;System;Techniques;temporal measurement;tool;two-dimensional;Work

PROJECT_TITLE: Protein Structure, Dynamics, and Aggregation in Phase Separated Droplets


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative This project investigates the underlying mechanisms related to the acquisition of de novo pro-metastatic properties in breast tumor cells after treatment with neo-adjuvant chemotherapy. Outcomes will reveal how the tumor microenvironment influences the generation of cancer cell subpopulations that have the ability to both disseminate and seed a new tumor at the metastatic site. Findings will be applied toward new diagnostic and therapeutic tools for counteracting this unwanted side-effect of neo-adjuvant chemotherapy.

PI_NAMEs: KARAGIANNIS, GEORGE S (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Actins;Adjuvant Chemotherapy;Aftercare;Anatomy;Animal Model;Award;Behavior;Biology;Blood Vessels;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Breast Carcinoma;cancer cell;Cancer Etiology;cancer stem cell;career development;Cell Communication;Cells;Cellular biology;Chemoresistance;chemotherapy;Clinical;clinical care;Collaborations;college;conditional knockout;Coupled;CSF1 gene;Cyclophosphamide;density;design;Development;Dichloromethylene Diphosphonate;Disseminated Malignant Neoplasm;Distant;Doxorubicin;Education;Endothelial Cells;Ensure;Environment;Ephrins;experimental study;Frequencies;Funding;Generations;Genetic;genetic regulatory protein;Goals;Hematogenous;Histopathology;Imaging Device;Immune;improved;In Vitro;in vitro Assay;in vivo;Infiltration;inhibitor;interest;Intervention;intravital imaging;Laboratories;Literature;Lung;Macrophage;Malignant Breast Neoplasm;Mammary Neoplasms;MDA MB 231;Mediating;Medicine;Mentors;Metastasis Induction;Metastatic Neoplasm to the Lung;metastatic process;Microanatomy;microscopic imaging;Microscopy;Modality;Modeling;Molecular;mortality;mouse model;multi-photon;multiphoton microscopy;Mus;Neoadjuvant Therapy;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;notch protein;novel diagnostics;novel therapeutics;Outcome;Paclitaxel;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Phase;Phenotype;Physicians;predictive marker;Primary Neoplasm;Property;Protein Isoforms;Publications;recruit;Reporter;Research;response;Role;Scientist;Secondary to;side effect;Signal Pathway;Signal Transduction;Site;stem;stem cell biology;stem cell biomarkers;stem cell niche;Stem Cell Research;stem cells;stemness;System;Testing;tissue fixing;tool;Touch sensation;Training;Transgenic Animals;Transgenic Organisms;translational medicine;Translational Research;Transplantation;treatment strategy;tumor;tumor growth;tumor initiation;tumor microenvironment;Tumor-associated macrophages;Universities;Xenograft procedure

PROJECT_TITLE: Prometastatic Effects of Neoadjuvant Chemotherapy in Breast Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Sleep Research

ORG_CITY: Boulder

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Circadian clocks are present in most tissues of the body with importance for optimal physiological function and behavior. This project will utilize rigorous circadian approaches to systematically test novel hypotheses about the regulation of known biomarkers of peripheral circadian rhythms in humans, and for discovery of new biomarkers of peripheral rhythms in humans. We anticipate our findings will be the first step in developing novel circadian based treatments for aligning peripheral clocks and for developing novel circadian biomarkers that will advance our scientific understanding of circadian rhythms.

PI_NAMEs: WRIGHT, KENNETH P (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Address;Adipose tissue;analytical tool;Behavior;Behavioral;Biological Markers;biomarker development;biomarker identification;Body Temperature;bone;C-reactive protein;Cells;chemokine;circadian;Circadian desynchrony;circadian pacemaker;Circadian Rhythms;Clinical Trials;Cues;Darkness;Data;Development;Disease;Eating;Endothelial Cells;Endothelium;Food;fundamental research;Future;Gene Expression;ghrelin;Glucocorticoids;Glucose;Goals;Health;Hepatic;Hormones;Human;Hydrocortisone;IgE;Immune;improved;in vivo;Isomerism;Knowledge;Leptin;Ligands;Light;light entrainment;Lipids;Liver;Melatonin;men;Metabolic;Methodology;novel;novel marker;Outcome;Parathyroid gland;Peptide YY;Periodicity;Peripheral;Phase;Physical activity;Physiological;Physiological Processes;Plasma Proteins;Plasminogen Activator Inhibitor 1;Precision Medicine Initiative;Process;Proteins;Proteome;Proteomics;Protocols documentation;Publishing;Randomized;Regulation;Research;response;Sampling;Sleep;Small Intestines;Specificity;Stomach;Strategic Planning;Structure;suprachiasmatic nucleus;Sympathetic Nervous System;Testing;Theoretical model;Time;Tissues;treatment strategy;United States National Institutes of Health

PROJECT_TITLE: Biomarkers for Peripheral Circadian Clocks in Humans

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Data Science;Disability Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Pediatric;Rare Diseases

ORG_CITY: PARKTOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: WITS HEALTH CONSORTIUM (PTY), LTD

PHR: Developmental disorders (DD) represent a spectrum of often severe disabilities that are present from birth or early childhood. The Deciphering Developmental Disorders in Africa study (DDD-Africa) was started to describe and define the causes of DD in Africa, and this resource holds the potential for much more discovery, using data science- and omics techniques. To advance our knowledge, we propose to use the clinical information, genetic data, and DNA resources from the DDD-Africa study to increase diagnostic yield and make new discoveries about the causes of DD in African patients. These findings will lead to population-relevant and scalable solutions for Africa, fast-tracking genomics efforts for global health.

PI_NAMEs: LOMBARD, ZANE  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Acceleration;Address;Affect;Africa;African;American;Artificial Intelligence;Awareness;Birth;Caring;Cessation of life;Childhood;Chronic disability;Clinical;Clinical Data;clinical heterogeneity;Collaborations;Communicable Diseases;Complex;Computer software;Country;Data;Data Science;Death Rate;Democratic Republic of the Congo;developmental disease;Diagnosis;Diagnostic;disability;Disability phenotype;Disease;DNA;DNA Methylation;early childhood;Ecosystem;epidemiologic data;Ethics;exome;exome sequencing;experience;Genetic;genetic disorder diagnosis;Genetic Heterogeneity;Genetic Predisposition to Disease;Genetic Services;genome resource;genome-wide analysis;Genomic approach;Genomics;Genotype;global health;Health;health data;Healthcare;improved;indexing;Individual;Infant Mortality;innovation;Intellectual functioning disability;Knowledge;Knowledge Discovery;Medical;Medical Genetics;methylation pattern;Morbidity - disease rate;neglect;Neonatal Mortality;novel;Parents;Participant;Patients;Phenotype;phenotypic data;Population;population based;Prevalence;Public Domains;Rare Diseases;Reporting;Research;Resource Sharing;Resources;Sampling;Signs and Symptoms;South Africa;Survivors;Syndrome;Techniques;Time;tool;Translating;Variant;Work

PROJECT_TITLE: Advancing discovery for developmental disorders - expanded analysis of the DDD-Africa resource

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-L(70)R]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The Washington University Chronic Kidney Disease National Resource Center aims to improve resources available to the chronic kidney disease research community. This Center will provide a mechanism to test the pathogenicity of genetic variants of uncertain significance, resources to interrogate metabolism in vitro and in vivo, and an incubator space to further develop single cell omics technologies. A key objective is to share these resources with the larger O’Brien consortium and kidney research community to enhance research on the pathophysiology of chronic kidney disease.

PI_NAMEs: HUMPHREYS, BENJAMIN D. (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acceleration;Address;Adopted;Affect;Area;Bar Codes;Benign;bioinformatics pipeline;Biological Assay;biomedical resource;Cardiovascular system;Cell Culture Techniques;Cell Nucleus;Cells;Chronic;Chronic Kidney Failure;Code;Communication;Communities;computational pipelines;Consultations;cost;CRISPR/Cas technology;Data Analyses;Development;Disease;Diverse Workforce;Doctor of Medicine;Doctor of Philosophy;Education;Equipment;Evolution;Family;Fibrosis;Functional disorder;Funding;Genes;Genetic;Genetic Techniques;genetic testing;genetic variant;Genomic medicine;Genus Hippocampus;Goals;hands on instruction;improved;in silico;in situ sequencing;In Vitro;in vitro Assay;in vivo;Incubators;Injury;Injury to Kidney;Kidney;kidney biopsy;kidney metabolism;Lead;Leadership;Metabolic;Metabolism;metabolomics;Modeling;Morbidity - disease rate;mortality;multiple omics;Mus;novel therapeutic intervention;oxidation;Pathogenicity;Pathologic;Patients;Population;Pre-Clinical Model;programs;Proteins;Protocols documentation;Radioactive;recruit;Research;Research Personnel;Resolution;Resource Development;Resource Sharing;Resources;response to injury;RNA Splicing;Scientific Advances and Accomplishments;Services;single cell technology;stable isotope;Students;summer student;Techniques;technological innovation;Technology;Testing;Time;Tissues;tool;Tracer;Training;transcriptomics;Tubular formation;Underrepresented Minority;United States National Institutes of Health;Universities;Validation;Variant;variant of unknown significance;Washington;Work

PROJECT_TITLE: Washington University Chronic KidneyDisease National Resource Center


NIH_SPENDING_CATS: Genetics;Human Genome;Kidney Disease

PROJECT_TERMS: Automobile Driving;Bar Codes;bioinformatics pipeline;Biological Assay;biomedical resource;Cells;Chronic;Chronic Kidney Failure;Collaborations;Communication;Communities;cost;Cultured Cells;Development;Disease Progression;Diverse Workforce;diversity and inclusion;Doctor of Medicine;Doctor of Philosophy;Environment;Evolution;Faculty;Genes;genetic variant;Genus Hippocampus;Goals;in situ sequencing;In Vitro;in vivo Model;Infrastructure;Investigation;Kidney;kidney fibrosis;Lead;Leadership;Measures;Medical Students;metabolic phenotype;Metabolism;mouse model;new technology;new therapeutic target;novel;outreach;programs;Recovery;Research;Research Personnel;Resolution;Resource Development;Resources;Role;single nucleus RNA-sequencing;Spirometry;stable isotope;summer student;Technology;tool;Tracer;transcriptomics;Universities;Validation;Variant;Washington;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: MINER, JEFFREY H (contact)

PROJECT_TERMS: Affect;Amino Acid Sequence;Amino Acids;base;Benign;Biological Assay;Cell Culture Techniques;Chronic;Chronic Kidney Failure;Classification;clinical care;Code;Complex;cost effective;cost effectiveness;CRISPR/Cas technology;Cultured Cells;design;developmental disease;Diagnosis;Disease;DNA;Etiology;exome sequencing;Exons;experimental study;Family;Family Planning;Founder Generation;Gene Expression;Genes;Genetic;genetic disorder diagnosis;genome sequencing;genome wide association study;genome-wide;improved;in silico;In Vitro;in vitro Assay;in vivo;Kidney;Kidney Diseases;Link;Mediating;Mendelian disorder;Modeling;mouse genome;mouse model;Mus;Mutation;Pathogenesis;Pathogenicity;Pathology;Patients;protein function;Proteins;Research Personnel;research study;Resources;RNA;RNA Splicing;Services;Silicon Dioxide;Single Nucleotide Polymorphism;Symptoms;Testing;Time;trafficking;Universities;Validation;Variant;variant of unknown significance;Washington;whole genome

PROJECT_TITLE: Variant Validation Core


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE This application seeks support for an MD/PhD Program in Medicine, the Social Sciences, and Alzheimer’s Disease and Related Dementias (AD/ADRD) at the University of Chicago (UC) and Rush University (RU). The proposed program will produce MD/PhD graduates trained in medicine, a quantitative social science or related profession (Economics, Sociology, Psychology, Comparative Human Development, Public Health Sciences Business, Public Policy, and Social Work), and interdisciplinary approaches to AD/ADRD research. AD/ADRD research training areas will include: (1) the epidemiology of AD/ADRD; (2) the content, organization, and financing of care for persons with dementia; (3) behavioral, health system and community interventions aimed at the prevention, early identification, and treatment of AD/ADRD; (4) the care workforce and the role of formal and informal caregivers in health outcomes for persons with AD/ADRD; and (5) methodological issues prominent in AD/ADRD research.

PI_NAMEs: MELTZER, DAVID O (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Alzheimer's disease related dementia;Doctor of Philosophy;Medicine;programs;Social Sciences

PROJECT_TITLE: MD/PhD Program in Medicine, the Social Sciences and Alzheimer's Disease and Related Dementias


NIH_SPENDING_CATS: Kidney Disease;Nutrition

PI_NAMEs: GEWIN, LESLIE S (contact)

PROJECT_TERMS: Address;Affect;Biological Assay;biomedical resource;Cell Count;Cells;Chronic;Chronic Kidney Failure;Communities;Consult;Consultations;Data;design;disease model;Disease Progression;Doctor of Medicine;Doctor of Philosophy;Education;Electron Transport;Equipment;Faculty;fatty acid oxidation;Functional disorder;Genes;Genus Hippocampus;Glucose;Human;In Vitro;in vivo;Injury;Injury to Kidney;instrumentation;interest;Isotopes;Kidney;Kidney Diseases;liquid chromatography mass spectrometry;long chain fatty acid;Measures;Metabolic;Metabolism;metabolomics;Methods;Mitochondria;nutrition;Obesity;oxidation;Palmitates;Pathway interactions;Pharmaceutical Preparations;Play;Pre-Clinical Model;Process;protein expression;Proteins;Protocols documentation;Pyruvate;Radioactive;Reagent;Recommendation;Renal function;Renal tubule structure;Reproducibility;Reproducibility of Results;Research;Research Personnel;Resolution;Resources;Respiration;response;Role;Services;Spirometry;stable isotope;Standardization;Tissues;Tracer;Training;transcriptomics;Tubular formation;Universities;Update;Validation;Washington;Writing

PROJECT_TITLE: Metabolism Core


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Acute kidney injury (AKI) is a major cause for morbidity and mortality in hospitalized patients and is being increasingly recognized as a cause for chronic kidney disease and AKI doubles the length of stay in the hospital, increasing health care resources. The UAB-UCSD O’Brien Center for Acute Kidney Injury Research is an interdisciplinary center of excellence in AKI-related research, and is now proposing to be a member of the O’Brien Kidney Consortium as one of eight U54 National Resource Centers. This theme-based Center proposes to share resources, methods, and innovations with the Consortium to attract new scientific expertise into the field.

PI_NAMEs: AGARWAL, ANUPAM  (contact)

PROJECT_TERMS: Acceleration;Acute Renal Failure with Renal Papillary Necrosis;Address;Alabama;Biomedical Research;California;Center Core Grants;Chronic Kidney Failure;Clinical;Clinical Research;Collaborations;Collection;Communities;Core Facility;Data;Development;digital;Ecosystem;Electronic Health Record;Ensure;Environment;experience;Extramural Activities;Fostering;Functional disorder;Funding;Health;Healthcare;Hospitalization;Hospitals;Imagination;improved;in vivo imaging;Infrastructure;innovation;Institution;Investigation;Kidney;Kidney Diseases;Learning;Length of Stay;Machine Learning;member;metabolomics;Methods;Mission;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Paper;Patients;pre-clinical;pre-clinical research;Prevention;Publications;quality assurance;Quality Control;Reproducibility;Research;Research Peer Review;Research Personnel;Resource Development;Resource Sharing;Resources;Rodent Model;Services;summer student;Technology;Testing;tool;Training Programs;Translational Research;Universities

PROJECT_TITLE: UAB-UCSD O'Brien Center for Acute Kidney Injury Research


NIH_SPENDING_CATS: Kidney Disease

PHR: Project Narrative As per the RFA, not needed for individual components.

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Administrator;Alabama;authority;base;biomedical resource;California;catalyst;Collaborations;collaborative environment;Communication;Communities;Data;Decision Making;Development;Discipline;Doctor of Philosophy;Effectiveness;Ensure;Extramural Activities;Faculty;Fostering;Funding;Generations;Goals;Grant;Growth;Individual;Infrastructure;Institution;Interdisciplinary Study;Investments;Kidney;Laboratories;Logistics;Maintenance;Medical Research;Medical Students;meetings;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;novel;operation;outreach;pre-clinical;Productivity;programs;quality assurance;Quality Control;recruit;Reproducibility;Research;Research Personnel;Resource Development;Resource Sharing;Resources;Scientist;Services;Standardization;Structure;Students;success;summer student;synergism;Training and Education;Training Programs;United States National Institutes of Health;Universities;web site


PROJECT_TERMS: Adopted;Bar Codes;Bioinformatics;bioinformatics pipeline;Biological;Biology;Biomedical Research;biomedical resource;Cell Communication;Cell Nucleus;Cell Physiology;cell type;Cells;Chromatin;Chronic;Chronic Kidney Failure;Code;Communities;computational pipelines;Computer Analysis;cost;cost effective;Data;Data Analyses;Development;Dissociation;Equipment;Evolution;experimental study;Fibrosis;Future;Gene Expression;Generations;Genetic Transcription;Genomics;Heterogeneity;Human;Hyperactivity;in situ sequencing;Injury;intercellular communication;Investigation;Kidney;kidney fibrosis;Laboratories;Maps;Measurement;Measures;Methods;Microfluidics;Morphology;mouse model;multiple omics;Mus;nephrogenesis;Nuclear;Organ;Physiological;Protocols documentation;Reagent;repaired;Research;Research Personnel;Resolution;Resource Development;Resources;response;sample fixation;Sampling;Signal Pathway;single cell technology;single nucleus RNA-sequencing;single-cell RNA sequencing;Source;Stress;Suspensions;System;Technology;Testing;Time;tissue preparation;Tissues;Tn5 transposase;transcriptome sequencing;transcriptomics;Universities;Washington;Writing;XCL1 gene

PROJECT_TITLE: Development Core


NIH_SPENDING_CATS: Cancer

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE Physician-scientists functioning at the interface between laboratory research and clinical practice play a critical role in the translation of scientific discoveries into new diagnostics and therapeutics. The Clinical Scholars Biomedical Research Training Program (CSTP) is designed to prepare board eligible/certified physician- scientists to carry out independent laboratory-based research aimed towards clinical translation. These individuals will increase our understanding of the pathogenesis of cancer and lead the development of new cancer treatments.

PI_NAMEs: CHI, PING  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Networking and Information Technology R&D (NITRD)

PI_NAMEs: NEYRA, JAVIER A. (contact)

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;base;Basic Science;Benchmarking;Big Data;biobank;Bioinformatics;bioinformatics resource;bioinformatics tool;Biological Specimen Banks;Center Core Grants;Classification;Clinical;Clinical and Translational Science Awards;clinical center;Clinical Data;clinical data repository;clinical database;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communication;Communities;computing resources;Consultations;COVID-19;Data;data acquisition;data mining;data resource;Databases;design;Development;digital;electronic health data;Electronic Health Record;Epidemiologic Monitoring;Epidemiology;federated learning;Female;Funding;Goals;Healthcare;Heterogeneity;Human;Human Resources;Incidence;Individual;Industry;Infrastructure;innovation;Institution;interest;Kidney;Kidney Diseases;Link;male;Medicine;Methodology;Methods;novel;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Peer Review;Peptides;personalized medicine;Phenotype;Policies;pre-clinical;preclinical evaluation;preclinical imaging;programs;Public Health;Publications;Registries;Research;Research Personnel;Resource Development;Resources;response;Risk;Risk Factors;Science;small molecule;Structure;success;Technology;therapeutic target;tool;Translating;Translational Research;Translations;treatment effect;United States National Institutes of Health;Validation

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE We lack specific knowledge of the causes of neuromuscular impairment in post-stroke gait. The purpose of this proposal is to use state-of-the-art techniques in biomechanics and neurophysiology to investigate the complex web of impairments in people with reduced knee flexion following stroke. The information obtained from this work will lead towards improved and targeted interventions.

PI_NAMEs: SULZER, JAMES  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Abnormal coordination;abnormal reflex;Address;Affect;Age;Behavior;Belief;Biomechanics;clinically significant;Compensation;Complex;Computing Methodologies;conditioning;conventional therapy;Couples;Coupling;Data;Development;Educational Intervention;Exhibits;exoskeleton;experience;experimental study;femoral nerve;foot;functional restoration;Gait;Gait abnormality;Goals;H-Reflex;Hip region structure;Homosynaptic Depression;Human;Hyperactivity;Hyperreflexia;Impairment;improved;Individual;innovation;Internet;Intervention;kinematics;Knee;Knowledge;Lead;Link;Methods;Modeling;Motion;Motor Neurons;multidisciplinary;multimodality;Muscle;Muscle Weakness;Musculoskeletal;Nervous System Trauma;neural;Neurologic;neuromuscular;Neuronal Plasticity;neurophysiology;neuroregulation;Neurotransmitters;novel;novel strategies;Orthotic Devices;Pathologic;Pattern;Pelvis;Peripheral Nerve Stimulation;Persons;Phase;Physical therapy;post stroke;presynaptic;prevent;Procedures;Protocols documentation;quadriceps muscle;Qualifying;rectus femoris;Reflex action;Research;response;Robotics;Role;Self-Help Devices;side effect;Soleus Muscle;Spinal;spinal reflex;stem;Stimulus;stretch reflex;Stroke;targeted treatment;Techniques;Testing;treatment planning;Walking;Work;working group

PROJECT_TITLE: Combining neurophysiology and biomechanics to delineate post-stroke gait impairments

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE: The flow of protons across membranes is critical for bioenergetics, signaling and other biological processes. The transport of protons across cellular membranes could be potentially toxic to cells had proton channel proteins not fine-tuned their selectivity and rate of transmission (conductivity). This proposal aims to understand the mechanisms by which these proton channels achieve and fine-tune proton selectivity and conductivity through the detailed study of the influenza A virus matrix protein 2 and synthetic designed proton channels.

PI_NAMEs: KRATOCHVIL, HUONG TRAN (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Acids;Affect;Amines;Binding;Bioenergetics;Biological Process;Biophysics;Cell membrane;Cells;Cellular Membrane;Charge;computer studies;Crystallography;deprotonation;design;Diffusion;Dimensions;Disease;Drug resistance;Event;Glutamine;Hydration status;Hydrogen Bonding;Influenza;Influenza A virus;infrared spectroscopy;Ions;Lead;Length;Lipid Bilayers;Measurement;Mediating;Membrane;Molecular;Molecular Conformation;molecular dynamics;Motion;mutant;Mutation;novel;Pathway interactions;Permeability;Pharmaceutical Preparations;Phase;Play;Positioning Attribute;Process;Proteins;protonation;Protons;Replication-Associated Process;resistance mutation;Resolution;Role;Signal Transduction;Site;Stream;Structure;Testing;Time;transmission process;two-dimensional;Vertebral column;Viral;Virus Replication;Visualization;Water;Work

PROJECT_TITLE: Proton Conduction Pathways in Proton Channel Proteins

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: MANHATTAN

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: Project Narrative The presence of ion atmospheres around charged biomolecules is known to affect their properties and interactions. Here we develop a new view of ion atmospheres using an innovative combination of solution theory and local electroneutrality constraints. This new view has consequences for our understanding of several biophysical approaches used to characterize biomolecules and their properties, and has subsequent implications for a wide range of systems governing a variety of health-related problems.

PI_NAMEs: SMITH, PAUL E (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Affect;Agreement;Anions;Atmosphere;Behavior;biological systems;biomacromolecule;biophysical analysis;biophysical techniques;Biophysics;Boltzmann equation;Cations;Cell Physiology;Charge;Computer Simulation;Coupled;Crystallization;Data;Disease;DNA;DNA-Binding Proteins;DNA-Protein Interaction;Electrolytes;Experimental Models;Grain;Health;improved;In Vitro;innovation;Ionic Strengths;Ions;Knowledge;Lipid Bilayers;Liquid substance;macromolecule;Molecular;molecular dynamics;Morphologic artifacts;Nature;neglect;novel strategies;Osmosis;Osmotic Pressure;Phase;Play;pressure;Process;Property;Proteins;Rationalization;Research Personnel;Resolution;Role;Route;Salts;Series;Shapes;simulation;small molecule;Sodium Chloride;Solubility;Solvents;Structure;System;Temperature;theories;Thermodynamics

PROJECT_TITLE: Theory and Simulation of Local Electroneutrality and Ion Atmospheres in Biological Systems

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


PI_NAMEs: SANDERS, PAUL W. (contact)

PROJECT_TERMS: Acceleration;Acute Renal Failure with Renal Papillary Necrosis;animal imaging;Animal Model;animal model development;Animal Testing;Area;base;Basic Science;Benchmarking;Biological Assay;Blood Vessels;Capital;career;Cell Line;Cells;Communities;Core Facility;Country;COVID-19 pandemic;Creatinine;Data;design;Education;Educational Activities;Environment;Evaluation;Faculty;Feedback;Female;field study;Fostering;Functional disorder;Goals;hemodynamics;Human;human disease;human model;Human Resources;In Vitro;in vivo Model;Individual;insight;interest;Ischemia;Kidney;kidney cell;Kidney Transplantation;Knowledge;Liquid substance;male;Medicine;meetings;member;Metabolic;Metabolism;Methodology;Methods;Micropuncture;Mission;mouse model;Nephrons;novel;Operative Surgical Procedures;Oxygen Consumption;Patients;Peer Review;Physiological;Physiology;pre-clinical;preclinical study;Preventive;Procedures;Process;Production;Publications;Quality Control;Renal function;renal tubular reabsorption;Reperfusion Injury;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Rodent;Rodent Model;Sampling;Sepsis;Services;skills;Technical Expertise;Techniques;Technology;therapeutic evaluation;tool;Training;Translations;Transplantation;Tubular formation;web site

PROJECT_TITLE: Pre-Clinical Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Clinical Research;Data Science;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Acceleration;Acute Renal Failure with Renal Papillary Necrosis;Address;Adoption;Anatomy;Animal Model;Area;Artificial Intelligence;Big Data;Biologic Characteristic;Biological;Biological Assay;Biology;biomedical resource;Caring;Classification;Clinical;Clinical Research;Data;Data Analyses;data harmonization;data management;data platform;Development;digital;Disease;Electronic Health Record;Etiology;Evaluation;federated learning;Feedback;Focus Groups;Future;Goals;health inequalities;Heterogeneity;high standard;Image;implementation science;improved;in vivo imaging;Incubated;Incubators;Individual;Infrastructure;innovation;Institution;Interview;Kidney;Leadership;Learning;Magnetic Resonance Imaging;metabolomics;Methodology;Methods;Microfluidics;Molecular;multi-task learning;new technology;novel;novel therapeutics;Pathway interactions;patient oriented;Patients;Peptides;Persons;Phenotype;phenotypic data;Physiology;Policies;Positron-Emission Tomography;pre-clinical;pre-clinical research;preclinical imaging;Procedures;Protocols documentation;Reproducibility;Research;research clinical testing;Research Methodology;Research Personnel;Resolution;Resource Development;Resources;response;Risk;Services;small molecule;Sustainable Development;System;Technology;Testing;Thinking;Time;Tissues;tool;translational applications;Translational Research;treatment effect;Validation

PROJECT_TITLE: Resource Development Core


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;Human Genome;Immunization;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: MADISON

ORG_NAME: DNASTAR, INC.

ORG_STATE: WI

PHR: The immune system of each individual produces roughly 1010 different antibodies, collectively known as their antibody repertoire, that are critical for responding to infections and vaccinations and which also play a key role in autoimmune diseases. Generating the immense diversity unique to each individual requires complex biology at each level of central biology: germline DNA, expressed mRNA in the antibody producing B-cells and the 3D structures of the final protein antibodies themselves as well as their interactions with target antigens. In this project, we use cutting edge software approaches to decipher and mine this crucial branch of the immune system with the goal of accelerated development of next-generation diagnostics and therapeutics.

PI_NAMEs: BLATTNER, FREDERICK R;DURFEE, TIMOTHY J (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 3-Dimensional;Acceleration;Adaptive Immune System;Affinity;Allergens;Antibodies;Antibody Affinity;Antibody Formation;Antibody Repertoire;antigen binding;Antigen Targeting;Antigens;Autoimmune Diseases;B-cell receptor repertoire sequencing;B-Lymphocytes;Binding;Biology;Biotechnology;Cells;Characteristics;clinical care;clinical decision-making;Clonal Expansion;Code;Communities;Complex;Computer Hardware;Computer software;Computers;contig;cost effective;Data;deep learning;Development;Diagnostic;diagnostic development;Distant;DNA;Emerging Technologies;environmental agent;Epitopes;Future;Genes;Genetic;Genetic Recombination;Genomics;Germ Lines;Goals;Grouping;Haplotypes;Health;Healthcare;Hour;Human;Immune system;Immunoglobulin Somatic Hypermutation;improved;in silico;Individual;Infection;interest;Libraries;Light;Malignant Neoplasms;member;Messenger RNA;Modeling;Molecular Conformation;Molecular Immunology;Nature;neutralizing antibody;novel diagnostics;pathogen;Performance;personalized medicine;Phase;Play;Population;Process;programs;protein purification;protein structure;Proteins;Recording of previous events;Research;research and development;Resources;response;Role;Running;SARS-CoV-2 spike protein;screening;software development;Specialist;Specificity;structural biology;Structure;System;Technology;Therapeutic;therapeutic development;three dimensional structure;tool;transcriptome sequencing;Translating;Vaccination;Validation;Variant;virtual

PROJECT_TITLE: Software for the complete characterization of antibody repertoires: from germline and mRNA sequence assembly to deep learning predictions of their protein structures and targets


ORG_CITY: LAWRENCE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

PHR: Project Narrative The proposed research will facilitate development of modeling techniques capable of delivering starting points for structure-based drug design by providing structural information on docking modes of existing and potential drug targets.

PI_NAMEs: VAKSER, ILYA  (contact)

PROJECT_TERMS: Assessment tool;automated assessment;Benchmarking;Binding;Biology;blind;Cell Physiology;Cells;Communities;Complex;Computer Assisted;data resource;Database Management Systems;Databases;Development;Disease;Docking;Drug Design;Drug Targeting;experimental study;Feedback;frontier;Goals;Growth;improved;Individual;Joints;Kinetics;Knowledge;Libraries;Life;macromolecular assembly;Macromolecular Complexes;macromolecule;Medicine;Methodology;Methods;Modeling;Molecular;molecular recognition;Molecular Structure;new therapeutic target;operation;Probability;Procedures;Process;protein complex;Proteins;Protocols documentation;reconstruction;Research;Resource Development;Resources;Role;role model;Source;structural biology;Structural Models;Structure;System;Techniques;tool;Update;user-friendly;Visualization software

PROJECT_TITLE: Integrated Resource for Protein Recognition Studies

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


NIH_SPENDING_CATS: Cancer;Skin Cancer

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Melanoma is an important public health problem with increasing incidence worldwide. Thus, there is an urgent need to develop better and longer lasting therapies for this cancer. This is particularly critical for patients with NRAS-mutant melanoma, a highly aggressive tumor type with limited treatment options. We will capitalize on our discovery that the ribosomal protein S6 kinase 2 (S6K2) is essential for the survival of NRAS-mutant tumors. The purpose of this proposal is to investigate the role of S6K2 for melanoma survival and drug resistance. We aim at providing the preclinical basis to enable the development of novel and efficacious therapies for NRAS-mutant melanoma, an aggressive and deadly disease.

PI_NAMEs: VILLANUEVA, JESSIE  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Biochemical;Biology;BRAF gene;cancer therapy;cancer type;Cell Death;Cell Line;Cell Survival;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Data;Dependence;design;Development;digital;Disease;Disease Progression;Drug resistance;effective therapy;efficacious treatment;Enzymes;experience;Fostering;FRAP1 gene;Genes;genetic approach;Goals;Homeostasis;Immunotherapy;improved;improved outcome;Incidence;inhibitor;Knock-out;Link;lipid metabolism;Lipid Peroxidation;Lipids;MAP Kinase Gene;Mediating;MEKs;Melanoma;Melanoma Cell;Melanoma patient;Metabolic;Metabolic Control;metabolic profile;Mitogen-Activated Protein Kinase Inhibitor;Molecular;Molecular Target;mouse model;mutant;Mutation;neoplastic cell;new therapeutic target;novel;novel strategies;novel therapeutics;Oncogenic;Oxidation-Reduction;Pathway interactions;Patients;Pharmacotherapy;Phosphotransferases;PIK3CG gene;Population;PPAR alpha;pre-clinical;Prognosis;Proliferating;Protein Isoforms;Public Health;Reactive Oxygen Species;Relapse;Reporting;Research;Resistance;response;restraint;Ribosomal Protein S6 Kinase;Role;Signal Transduction;Skin Cancer;targeted treatment;Testing;Therapeutic;therapeutic target;therapeutically effective;Toxic effect;transcriptomics;tumor;tumor heterogeneity;tumor microenvironment;Up-Regulation

PROJECT_TITLE: Targeting S6K2 to Overcome Drug Resistance in NRAS-mutant Melanoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: New Generation of General AMBER Force Field for Biomedical Research We plan to develop a new generation of general AMBER force field (GAFF3) for studying biomolecule-ligand interactions. GAFF3 will be critically evaluated in protein-ligand and nucleic acid-ligand binding free energy predictions using a novel GPU-accelerated λ-dynamics based orthogonal space tempering (OST) algorithm. We will apply a variety of strategies to further improve the performance of GAFF3 until it approaches the best performance an additive force field model can achieve.

PI_NAMEs: WANG, JUNMEI  (contact);YANG, WEI

PROJECT_TERMS: ABCG2 gene;Acceleration;Agonist;Algorithms;antagonist;Benchmarking;Binding;Binding Proteins;Biochemical;Biological;Biological Models;Biomedical Research;Biophysics;Boron;Charge;Chemicals;comparative;Computer Assisted;Computer software;Coupled;Data;Data Set;Development;Divalent Cations;Docking;Drug Design;Drug Targeting;Elements;Evaluation;Event;field study;Free Energy;Generations;Goals;improved;insight;Ligand Binding;Ligands;macromolecule;mechanical force;Methods;Modeling;Molecular;Molecular Conformation;molecular mechanics;neural network;next generation;novel;novel strategies;Nucleic Acids;Outcome;Pathway interactions;Performance;Pharmaceutical Preparations;Play;Positioning Attribute;Procedures;Proteins;Published Comment;receptor;Reproduction;Research;Role;Sampling;Selenium;simulation;small molecule;success;Techniques;Testing


PHR: PROJECT NARRATIVE We are applying recent advances in our understanding of the biology of prostate cancer to develop new treatments that are matched to the specific underlying causes of an individual’s disease. Our program will allow us to better distinguish between slow-growing cancers and those that require more aggressive treatment, better predict which drugs will work for which patients, better assess if the treatments patients are receiving are working, and develop new therapies for men with advanced disease who are not or no longer benefitting from available treatments.

PI_NAMEs: CHEN, YU ;SCHER, HOWARD I (contact)

PROGRAM_OFFICER_NAME: SCROGGINS, BRADLEY TODD

PROJECT_TERMS: Address;Adoption;advanced disease;aggressive therapy;androgen deprivation therapy;Androgen Receptor;anti-cancer research;behavioral response;Biological Assay;Biological Markers;Biology;Blood;Blood Tests;cancer clinical trial;cancer therapy;Castration;cellular imaging;Cessation of life;Clinic;Clinical;clinical practice;clinically relevant;clinically significant;Collaborations;Data Set;Dedications;design;Development;Disease;Disease Management;Disease Progression;Disease Resistance;Disseminated Malignant Neoplasm;DNA Repair;DNA Sequence Alteration;drug development;efficacy evaluation;Functional disorder;Genomics;Germ Lines;Goals;Heterogeneity;high risk;Histologic;Hormones;Human;Image;imaging biomarker;improved;improved outcome;Individual;Indolent;Industry;inhibitor;Institution;Localized Disease;Malignant neoplasm of prostate;Malignant Neoplasms;Memorial Sloan-Kettering Cancer Center;men;Molecular;molecular imaging;molecular subtypes;multidisciplinary;Mutation;Neoplasm Metastasis;new therapeutic target;next generation;novel;novel diagnostics;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;outcome prediction;Pathway interactions;Patient risk;Patients;Pharmaceutical Preparations;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;Pre-Clinical Model;preclinical development;predicting response;Prevalence;prognostic model;programs;Prostate;prostate cancer progression;Quality of life;RB1 gene;Receptor Signaling;Recommendation;Reproduction spores;Research;Research Personnel;Research Project Grants;Resistance;response;Risk;Role;Science;Signal Transduction;Specific qualifier value;targeted agent;targeted treatment;Therapeutic;Therapeutic Intervention;therapy resistant;tissue biomarkers;Tissues;TP53 gene;Translating;translational potential;Treatment Efficacy;treatment response;trial design;tumor growth;tumor heterogeneity;Tumor Subtype;Validation;virtual;Work;working group

PROJECT_TITLE: SPORE in Prostate Cancer


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Urologic Diseases

PI_NAMEs: SCHER, HOWARD I (contact)

PROJECT_TERMS: cancer clinical trial;career;clinical trial enrollment;Collaborations;Committee Members;Communication;Communities;community engagement;computer network;Data;data management;Data Management Resources;data science management;Deposition;Development;Doctor of Philosophy;editorial;Educational Activities;Ensure;Fostering;Funding;genomic data;Grant;Human Resources;Infrastructure;Institution;Maintenance;Malignant neoplasm of prostate;Manuscripts;Medical;meetings;member;Memorial Sloan-Kettering Cancer Center;Minority Groups;minority patient;National Cancer Institute;Occupational activity of managing finances;Office of Administrative Management;operation;Patient advocacy;patient engagement;programs;Prostate;Publications;Regulation;Reporting;repository;Research;Research Personnel;Research Project Grants;scientific organization;Services;support network;Training;Translational Research;Underserved Population;Work

PROJECT_TITLE: Core A: Administrative Core


ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative The proposed research will develop chemical approaches to investigate protein glutathionylation triggered by the reactive oxygen species. These approaches will be used to understand protein glutathionylation that serves as underlying mechanisms of cell migration. Insights learned from the proposed research will benefit development of diagnostic and therapeutic strategies for migration-related disorders.

PI_NAMEs: AHN, YOUNG-HOON  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Advanced Malignant Neoplasm;Affect;Biochemical;Bioinformatics;Biological;Biological Assay;Biological Process;Biotin;Cell Line;Cell Migration Induction;cell motility;Cells;Cessation of life;Chemicals;chronic wound;Cysteine;D-Amino Acid Dehydrogenase;Data;Detection;diagnostic development;Disease;Economic Burden;Engineering;Event;fluorophore;Foundations;genetic regulatory protein;Glutathione;glutathione synthase;Guanosine Triphosphate Phosphohydrolases;Hydrogen Peroxide;Immune response;Impairment;In Situ;innovation;insight;Isotope Labeling;Learning;Link;Malignant Neoplasms;Mammalian Cell;Maps;MCF7 cell;Mediating;migration;Migration Assay;Molecular Target;mortality;mutant;Neoplasm Metastasis;novel;Organelles;oxidation;Oxidation-Reduction;Phosphoric Monoester Hydrolases;Play;Population;PPP2CA gene;Predisposition;Production;protein function;Protein S;Proteins;Proteomics;Reaction;Reactive Oxygen Species;Reporter;Research;Role;screening;Signal Pathway;Signaling Molecule;spatiotemporal;Sulfhydryl Compounds;System;Therapeutic;tissue repair;Work;wound;wound healing

PROJECT_TITLE: Chemical Proteomic Strategy to Investigate Cysteine Glutathionylation

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Human Genome;Immunotherapy;Precision Medicine;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE This project will leverage our deep institutional experience in somatic and germline tumor profiling to identify genomic alterations associated with progression to the lethal metastatic phenotype and molecular features associated with response to approved targeted and immune-based therapies in DNA damage repair–deficient prostate cancers. This will entail sequencing of thousands of tumor samples and integration of data from plasma sequencing and whole-genome sequencing to define molecular features that cannot be elicited by tumor panel sequencing alone. We expect that this project will result in new and refined treatment approaches for men with advanced and metastatic prostate cancer.

PI_NAMEs: SOLIT, DAVID B. (contact)

PROJECT_TERMS: advanced prostate cancer;Alleles;androgen independent prostate cancer;Area;Basic Science;BRCA2 gene;Cancer Patient;Castration;cell free DNA;Clinical;clinical development;Clinical Sciences;clinical sequencing;Clinical Trials;Clonality;cohort;Data;data integration;Data Set;Disease;Disease Progression;Disease Resistance;disorder risk;DNA analysis;DNA Repair;DNA Repair Disorder;DNA Repair Pathway;DNA Sequence Alteration;Doctor of Philosophy;drug response prediction;Enrollment;experience;FDA approved;Frequencies;Funding;Gene Mutation;gene repair;Genes;Genetic Determinism;Genetic Fingerprintings;genome analysis;genome sequencing;genomic data;genomic predictors;Genomics;Germ Lines;Goals;Heterogeneity;high risk;homologous recombination deficiency;immune checkpoint blockade;Immunotherapy;individual patient;inhibitor therapy;Institution;Institutional Review Boards;Investigational Therapies;Leadership;Localized Disease;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metastatic Prostate Cancer;Microsatellite Instability;Mismatch Repair Deficiency;Molecular;Molecular Profiling;Molecular Target;mutant;Mutation;mutational status;Natural History;Neoplasm Metastasis;novel;Operative Surgical Procedures;optimal treatments;Outcome;PARP inhibition;Pathway interactions;Patient Selection;patient subsets;Patients;pembrolizumab;Phenotype;Plasma;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;predict clinical outcome;Primary Neoplasm;profiles in patients;prognostic;prospective;prostate cancer progression;Recurrence;Recurrent disease;Resistance;response;Risk Reduction;Sampling;Solid Neoplasm;standard care;targeted sequencing;targeted treatment;Testing;treatment response;tumor;tumor heterogeneity;Variant;whole genome

PROJECT_TITLE: Project 1: Genomic Predictors of Clinical Outcomes and Response to Targeted Therapy in Advanced Prostate Cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Precision Medicine;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE Androgen blockade forms a main pillar of prostate cancer treatment, but even potent second-generation androgen receptor signaling inhibitors are only effective for a limited time, with most cancers ultimately progressing. We recently discovered a cellular growth factor, neuregulin 1, secreted by the local prostate cancer microenvironment, that promotes the survival of prostate cancer cells under conditions of androgen blockade. We aim to 1) study whether targeting neuregulin 1 can make androgen-directed therapies more effective, 2) discover other microenvironment-mediated mechanisms driving resistance to androgen-targeted therapies, and 3) develop therapeutic strategies to overcome these mechanisms to improve the cure rates for men with high-risk prostate cancer.

PI_NAMEs: CARVER, BRETT STEWART (contact)

PROJECT_TERMS: abiraterone;Acetates;Address;Adjuvant Study;advanced prostate cancer;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;antagonist;Automobile Driving;Basic Science;cancer cell;cancer initiation;cell growth;Cells;Clinical;clinical development;Clinical Sciences;Clinical Trials;cytokine;Cytokine Receptors;Data;Dependence;Development;Disease;Disease Progression;disorder control;DNA Sequence Alteration;Doctor of Philosophy;early phase clinical trial;enzalutamide;Epithelial Cells;ERBB2 gene;Generations;Genes;Genetically Engineered Mouse;Goals;Growth Factor;high risk;Hormones;Human;improved;Individual;inhibitor;Ligands;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mediating;Mediator;men;Metastatic Prostate Cancer;Molecular;Mus;Neoadjuvant Therapy;Neuregulin 1;Nonmetastatic;novel;novel strategies;Pathologic;Pathway interactions;Patients;Phase;Phase III Clinical Trials;phase III trial;PI3K/AKT;PIK3CG gene;Play;Population;Population Dynamics;Pre-Clinical Model;precision medicine;Precision medicine trial;preclinical trial;Prevalence;primary endpoint;Prior Therapy;Prostate;prostate cancer cell;prostate cancer model;prostate cancer risk;Prostate Cancer therapy;Prostatectomy;Proto-Oncogene Proteins c-akt;PTEN gene;Radical Prostatectomy;receptor;Receptor Inhibition;Receptor Signaling;Recurrence;Reporting;Resistance;response;Role;Science;Shapes;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Specimen;Stromal Cells;synergism;targeted treatment;Technology;Therapeutic;therapeutic target;Time;Tissue-Specific Gene Expression;tumor microenvironment;Work

PROJECT_TITLE: Project 2: Overcoming Microenvironment-Mediated Resistance to AR Pathway Inhibition in High-Risk Prostate Cancer


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Genetics;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Improving our ability to recover from injuries like heart attacks and strokes is a major goal of regenerative medicine. Stem cells produce new tissues after injury, but we do not fully understand the mechanisms that control their behavior. This proposal will leverage the unlimited regenerative capacity and abundant stem cell population in planarian flatworms to identify the signaling pathways that control stem cell responses to surgical injuries.

PI_NAMEs: ADLER, CAROLYN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Amputation;Animals;Apoptosis;Automobile Driving;Behavior;Biochemistry;Biological Assay;cell behavior;Cell Cycle;Cell Cycle Arrest;Cell Differentiation process;Cell division;Cells;Chemicals;Cues;design;differentiation in vitro;DNA;DNA Repair;embryonic stem cell;Epidermal Growth Factor Receptor;Extracellular Signal Regulated Kinases;Fibroblast Growth Factor Receptors;flexibility;forkhead protein;Foundations;Future;G2/M Checkpoint Pathway;gene conservation;gene regulatory network;Genes;Goals;Homeostasis;improved;Induction of Apoptosis;injured;Injury;Kinetics;knock-down;lens;Ligands;Membrane;Methods;Microtubules;Mitogen-Activated Protein Kinases;model organism;Molecular;Monitor;Myocardial Infarction;Natural regeneration;Nocodazole;Organ;organ regeneration;Pathway interactions;Pharmacology;Pharyngeal structure;Phosphorylation;Phosphotransferases;Physiological;Planarians;Platyhelminths;Pluripotent Stem Cells;progenitor;Proliferating;Radiation;receptor;regenerative approach;Regenerative capacity;Regenerative Medicine;response;response to injury;RNA Interference;RNA interference screen;Signal Pathway;Signal Transduction;single cell sequencing;single-cell RNA sequencing;stem cell differentiation;stem cell population;stem cell proliferation;stem cells;Stroke;Surgical Injuries;Technology;Testing;tissue regeneration;Tissues;Transcript;Transcriptional Activation;transcriptome;transcriptome sequencing;Up-Regulation

PROJECT_TITLE: Mechanisms driving stem cell responses to injury in planarians

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE Recent genomics studies have shown that men with castration-resistant metastatic prostate cancer harbor an unexpectedly high frequency of alterations in the tumor suppressor genes TP53 and RB. In laboratory studies, we have found that these alterations lead tumor cells to change their identity and thereby become resistant to anticancer therapies that target the androgen receptor. In this project, we will characterize these altered tumor cells through single-cell analysis, evaluate four inhibitory therapies that may delay, prevent, or even reverse the changes that cause resistance, and develop blood-based biomarkers that can be incorporated into clinical trials to predict and monitor patient response to these types of therapies.

PI_NAMEs: SAWYERS, CHARLES L. (contact)

PROJECT_TERMS: abiraterone;Address;Adenocarcinoma;androgen independent prostate cancer;Androgen Receptor;Atlases;Biological Assay;Biological Markers;biomarker validation;Biopsy;Blood;blood-based biomarker;cancer clinical trial;cancer therapy;Castration;Cell Death;cell free DNA;Cells;Chromatin;Chromogranins;Chromosomal Instability;Clinical;clinical development;Clinical Trials;Confusion;Copy Number Polymorphism;Cytokeratin;Cytokeratin-8 Staining Method;Data;Detection;Development;Diagnostic;DNA analysis;DNA Markers;DNA Sequence Alteration;Drug Targeting;Eligibility Determination;enzalutamide;EP300 gene;Epithelium;Evaluation;Evolution;exome;experience;EZH2 gene;Fibroblast Growth Factor Receptors;Frequencies;Funding;Future;Genetic Markers;Genetically Engineered Mouse;Genomics;Goals;Growth;Heterogeneity;Histology;Human;human tissue;Imaging technology;Immunofluorescence Immunologic;Immunohistochemistry;Inflammatory;inhibitor;insight;Institutional Review Boards;Inter-tumoral heterogeneity;Investigation;JAK1 gene;JAK2 gene;Janus kinase;Laboratory Study;Lead;Malignant neoplasm of prostate;Measures;men;Mesenchymal;Metastatic Prostate Cancer;Modeling;Molecular;Monitor;morphological criteria;Morphology;Mus;Mutation;Neoplasm Circulating Cells;neoplastic cell;Neurosecretory Systems;new therapeutic target;novel;Organoids;Pathway interactions;Patient Monitoring;patient response;Patients;Phenotype;Phosphotransferases;Population;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;Prediction of Response to Therapy;prevent;programs;Prospective Studies;Prostate;Prostate Adenocarcinoma;Prostate-Specific Antigen;Proteins;RB1 gene;Receptor Signaling;research clinical testing;Resistance;resistance mechanism;response;RNA;Sampling;Science;Series;Signal Pathway;single cell analysis;single cell ATAC-seq;single cell technology;single-cell RNA sequencing;Source;specific biomarkers;Specimen;standard measure;stem;success;Synaptophysin;T-Cell Activation;targeted cancer therapy;targeted treatment;Technology;therapeutic development;Therapeutic Effect;Therapeutic Intervention;therapeutic target;Tissue Microarray;Tissues;TP53 gene;transcriptome sequencing;tumor;tumor DNA;tumor heterogeneity;Tumor Suppressor Genes;Undifferentiated;whole genome;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Project 3: Therapeutic Targeting of Lineage Plasticity in Castration-Resistant Prostate Cancer


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Neurosciences

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The aim of this proposal is to enhance the career development of the candidate through 1) a didactic Master of Science program in translational research as well as formal neuroscience training and 2) patient-oriented research in autonomic neuromodulation. A longstanding goal of cardiovascular research is to characterize the role of the autonomic nervous system in the pathogenesis of cardiac arrhythmias and technical advances in neuroscience have given rise to powerful new ways to interact with neural circuits. Application of these new methodologies in the investigation of the cardiac-neural axis and in the treatment of patients with VT storm may provide critical information regarding the mechanistic characterization of complex autonomic pathways and help establish the role of a novel method of neuromodulation.

PI_NAMEs: MARKMAN, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Ablation;Advisory Committees;American;Anti-Arrhythmia Agents;arm;Arrhythmia;Autonomic ganglion;Autonomic nervous system;Autonomic Pathways;Cardiac;Cardiac ablation;Cardiac Electrophysiologic Techniques;Cardiovascular Diseases;Cardiovascular system;career;career development;Catecholamines;Catheters;Cervical;Clinical;Clinical Trials;cohort;Complement;Complex;Critical Illness;cytokine;Data;Development;efficacy evaluation;Electrophysiology (science);Evaluation;experience;Frequencies;Funding;Future;Goals;Health Resources;heart innervation;Hour;improved;Inflammatory;innovation;interdisciplinary collaboration;Interruption;Investigation;ischemic cardiomyopathy;Magnetism;Master of Science;Measurable;Measurement;Measures;Medicine;Mentors;Mentorship;Methodology;Methods;Morbidity - disease rate;mortality;nerve supply;neural;neural circuit;Neural Pathways;neuromechanism;neuroregulation;Neurosciences;Neurosciences Research;novel;Operative Surgical Procedures;Pathogenesis;Pathway interactions;patient oriented research;Patients;Peripheral;Physiological;Positioning Attribute;primary endpoint;Procedures;programs;Property;Protocols documentation;Publishing;Randomized;Refractory;Reproducibility;Research;Research Personnel;Risk;Role;Structure of stellate ganglion;sudden cardiac death;Sympathectomy;Synapses;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;tool;Training;Training Programs;transcutaneous stimulation;Translational Research;United States National Institutes of Health;Vasodilation;Ventricular;Ventricular Arrhythmia;Ventricular Tachycardia;Work

PROJECT_TITLE: Mechanistic refinement of non-invasive autonomic neuromodulation for cardiac arrhythmia

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE Through the work of the MSK SPORE in Prostate Cancer, supported by the Biospecimen Repository Core, we hope to increase our understanding of the clinical, biologic, and genetic basis of prostate cancer to improve patient outcomes; to facilitate a range of scientific activities that could lead to new genomic- and proteomic- based interventions for cancer, including target identification and validation; and to develop new biomarkers, diagnostics, and pharmacogenomic analyses.

PI_NAMEs: GOPALAN, ANURADHA  (contact)

PROJECT_TERMS: animal tissue;anti-cancer research;Antibodies;Bioinformatics;Biological;Biological Assay;Biological Markers;Biological Specimen Banks;Biometry;Biopsy;Blood;Blood specimen;Cancer Intervention;Characteristics;Clinical;Clinical Chemistry;Clinical Laboratory Improvement Amendments;Clinical Trials;Collaborations;Communities;Consent;Credentialing;data quality;design;Diagnostic;digital;disease model;Documentation;Evaluation;exosome;follow-up;Formalin;Freezing;Gene Expression Profiling;Genes;Genetic;Genomics;Germ Lines;Goals;Guidelines;human tissue;Image;improved;In Situ Hybridization;Individual;Institutional Review Boards;Laboratories;Malignant neoplasm of prostate;Measures;Methodology;Microdissection;Morphology;mouse model;Mus;Needle biopsy procedure;Neoplasm Metastasis;neoplasm resource;novel;novel marker;Nucleic Acids;Paraffin Embedding;participant enrollment;Pathologic;Pathology;Patient-Focused Outcomes;Patients;Performance;Pharmacogenomics;Phenotype;Pilot Projects;Plasma;Play;Pre-Clinical Model;Preparation;Process;prospective;Prostate;prostate cancer model;Proteomics;Protocols documentation;Publications;quality assurance;Quality Control;Radical Prostatectomy;Recording of previous events;relational database;Research;Research Personnel;Research Project Grants;Research Support;Role;Sampling;Scanning;Serum;Services;Specimen;Stains;Standardization;System;tissue archive;Tissue Embedding;Tissue Microarray;Tissue Procurements;Tissue Sample;Tissues;Translational Research;Tube;tumor;Validation;web site;Whole Blood;Work;Xenograft Model

PROJECT_TITLE: Core B: Biospecimen Repository


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE The Biostatistics and Bioinformatics Core assists the research efforts of the Memorial Sloan Kettering Cancer Center SPORE in Prostate Cancer investigators, contributing to the design and analysis of clinical, genomic and laboratory research, and the development of valid conclusions. The core provides statistical analysis and consultancy as well as ongoing quality assurance. The core has also established a data quality working group to improve the quality of SPORE data.

PI_NAMEs: GONEN, MITHAT  (contact)

PROJECT_TERMS: Address;advanced prostate cancer;anti-cancer research;Area;Bioinformatics;Biometry;Clinical;clinical trial analysis;Clinical Trials;Clinical Trials Design;Collaborations;Computing Methodologies;Data;Data Analyses;data quality;design;Development;Doctor of Philosophy;Experimental Designs;Formulation;Genomics;improved;Individual;Laboratories;laboratory experiment;Laboratory Research;Malignant neoplasm of prostate;member;Memorial Sloan-Kettering Cancer Center;Methodology;Outcome Assessment;Phase;Population;pre-clinical;preclinical study;preclinical trial;primary endpoint;Procedures;Protocols documentation;quality assurance;Randomized;Research;Research Methodology;Research Personnel;Role;Sample Size;secondary endpoint;Statistical Data Interpretation;trial design;working group

PROJECT_TITLE: Core C: Biostatistics & Bioinformatics Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Pediatric Cancer;Prevention;Primary Health Care;Rare Diseases

ORG_CITY: MARBLEHEAD

ORG_NAME: IMPLENOMICS LLCS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Adolescents and young adults living with HIV experience higher premature mortality from cancer than their uninfected peers. In Zambia, because of multilevel barriers, interventions for early diagnosis and optimized treatment to reduce this cancer mortality are underutilized for this disproportionally impacted cohort. In this study, we will test peer-to-peer education and support strategies to increase use of early diagnosis services in HIV treatment facilities and improve compliance with cancer treatment in the cancer center.

PI_NAMEs: MBIZVO, MICHAEL ;MSADABWE, SUSAN CITONJE;SUBRAMANIAN, SUJHA  (contact)

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: Address;Adherence;Administrator;Adolescent and Young Adult;Adult;African;Age Years;AIDS related cancer;antiretroviral therapy;Cancer Burden;cancer care;Cancer Center;Cancer Control;cancer diagnosis;Cancer Model;Cancer Patient;cancer referral center;cancer risk;cancer therapy;care delivery;Caring;CD4 Lymphocyte Count;Childhood;cohort;Communities;Consultations;Continuity of Patient Care;Cost Analysis;cost effectiveness;cost-effectiveness evaluation;Country;Data;Data Set;design;Diagnostic Services;Diagnostic tests;Disease;Early Diagnosis;Early Intervention;economic evaluation;Education;effectiveness evaluation;Ensure;evidence base;experience;Face;Feedback;future implementation;Goals;Guidelines;Health care facility;Health Policy;Health Services;Healthcare;Healthcare Systems;HIV;HIV diagnosis;Hospitals;implementation efforts;implementation evaluation;implementation outcomes;implementation science;implementation trial;improved;Incidence;incremental cost-effectiveness;Individual;individual patient;Intervention;Investments;Kaposi Sarcoma;Knowledge;Learning;learning network;Link;Malignant Childhood Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mediating;member;Methods;Modeling;Morbidity - disease rate;mortality;Non-Hodgkin's Lymphoma;Nurses;Oncology;Outcome;Pamphlets;Patients;peer;peer learning;peer support;peri-urban;Persons;Physicians;Policies;policy implication;Policy Maker;premature;Premature Mortality;Prevalence;Preventive service;Primary Care;Process;Professional counselor;programs;Provider;Province;randomized trial;Rapid diagnostics;Recommendation;Reporting;Research;Resource-limited setting;Risk;Role;rural area;scale up;Screening for cancer;Self Efficacy;service uptake;Services;Signs and Symptoms;simulation;Specialist;survivorship;Testing;theories;treatment as usual;treatment optimization;treatment planning;treatment program;unethical;urban area;Vulnerable Populations;Work;Zambia

PROJECT_TITLE: Integrated delivery of cancer control interventions for adolescents and young adults living with HIV in Zambia


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE The study of prostate cancer has been limited by a lack of quality models that accurately recapitulate its molecular and phenotypic diversity. The Preclinical Models Core (Core D) is an essential component of our SPORE in Prostate Cancer because it will provide unparalleled access to state-of-the-art patient-derived and genetically engineered models. The core will also provide expert histopathologic analyses and preclinical trial design.

PI_NAMEs: CHEN, YU  (contact)

PROJECT_TERMS: androgen independent prostate cancer;Animal Model;biobank;BRCA2 gene;Cell Line;CHD1 gene;Clinical;Collaborations;design;Disease;DNA;Doctor of Philosophy;Engineering;Epithelial Cells;ERBB2 gene;Funding;Generations;Genes;Genetic Engineering;Genetically Engineered Mouse;Goals;Histologic;homologous recombination;Human;human disease;In Vitro;in vivo Model;interest;Knock-in Mouse;Knock-out;Malignant neoplasm of prostate;Modeling;Molecular;mouse model;Mouse Strains;Mus;Mutation;neuroendocrine differentiation;novel;NRG1 gene;Oncogenic;Organoids;Pathway interactions;patient derived xenograft model;Patients;Phenotype;PIK3CG gene;Poly(ADP-ribose) Polymerase Inhibitor;Pre-Clinical Model;preclinical trial;Prostate;prostate cancer model;Proteins;repository;Research Personnel;Resources;RNA;Services;success;therapy resistant;Tissues;Transgenic Organisms;Translational Research;trial design;validation studies

PROJECT_TITLE: Core D: Preclinical Models Core


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Prostate Cancer;Urologic Diseases

PHR: Project Narrative Designed to complement both research projects and other Cores within the MSK SPORE in Prostate Cancer, the goal of the Biomarkers Core is to accelerate the development and approval of biomarker tests that link biology to clinical outcomes. This will enable more informed diagnostic and therapeutic decisions, so that patient outcomes are improved.

PROJECT_TERMS: Academia;Acceleration;Address;Adherence;Basic Science;Benefits and Risks;Biocompatible Materials;Bioinformatics;Biological Assay;Biological Markers;Biological Specimen Banks;Biology;biomarker development;Biometry;Blood;Characteristics;Clinic;Clinical;clinical care;clinical practice;Clinical Protocols;Clinical Services;clinically relevant;Collection;Complement;Consent;Credentialing;Decision Making;design;Development;Diagnostic;Disease;disease heterogeneity;Disease Management;disease prognosis;drug development;Drug usage;Ensure;Evaluation;FOLH1 gene;Generations;Goals;Government;Human;Image;imaging biomarker;improved;improved outcome;Industry;innovation;Institutional Review Boards;interdisciplinary collaboration;Laboratories;laboratory development;Leadership;Link;Liquid substance;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;Methods;Modeling;Molecular;molecular oncology;Monitor;novel;Oncology;Organizational Models;Organoids;Outcome;Pathogenesis;Pathway interactions;patient derived xenograft model;Patient risk;Patient-Focused Outcomes;Patients;Positron-Emission Tomography;Pre-Clinical Model;Process;Program Development;programs;Protocols documentation;Publications;Qualifying;Reporting;Research Personnel;Research Project Grants;Resources;sample collection;Sampling;Schedule;Services;Structure;success;Technology;Testing;Therapeutic;Time;Translating;tumor;tumor growth;United States Food and Drug Administration;Validation

PROJECT_TITLE: Core E:Biomarkers Core


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Prostate Cancer;Urologic Diseases

PROJECT_TERMS: Acceleration;Address;Androgen Receptor;base;Biological Assay;Clinical;community center;Complement;Custom;Data;Development;Diagnosis;Disease Management;Doctor of Philosophy;Ensure;Etiology;Funding;Future;Generations;Goals;Growth;Health;high reward;high risk;Infusion procedures;innovation;Institution;International;Investigator-Initiated Research;Leadership;Life;Malignant neoplasm of prostate;Medicine;meetings;Memorial Sloan-Kettering Cancer Center;NCI Center for Cancer Research;Neoplasm Circulating Cells;New York;next generation sequencing;Peer Review;Pilot Projects;preference;Prevention;programs;prostate cancer prevention;Prostate Cancer therapy;Publications;Publishing;Qualifying;Reaction Time;Research;Research Personnel;Research Project Grants;Resources;Review Committee;Series;success;Techniques;Technology;Translational Research;translational research program;Universities;Urogenital Diseases;Work;working group

PROJECT_TITLE: Developmental Research Program


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

PI_NAMEs: EASTHAM, JAMES A (contact)

PROJECT_TERMS: anti-cancer research;Area;Basic Science;Biology;Biometry;Cancer Biology;cancer genetics;career;Clinical;Clinical Research;design;Education;Epidemiology;Ethics;experience;Exposure to;Faculty;Funding;Institution;inter-institutional;interest;knowledge base;Laboratory Research;lectures;Malignant neoplasm of prostate;member;Memorial Sloan-Kettering Cancer Center;Mentors;Participant;Physicians;professor;programs;Prostate;recruit;Research;Research Personnel;Resources;Schedule;Scientist;symposium;Teacher Professional Development;Training;Translational Research;Visit

PROJECT_TITLE: Career Enhancement Program


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE People living with HIV may have cognitive impairment despite treatment with antiretroviral therapy, and research using human autopsy brain samples and conducted in animal models has shown that injury to synapses in the brain might be an important underlying pathology of this impairment. We have developed a new PET imaging agent that binds to a protein in the vesicles of presynaptic nerve terminals, and shown in preliminary studies that scans using this tracer have the potential to be an imaging marker of synaptic density in well-treated people living with HIV. This study will use this new PET imaging agent to compare synaptic density in well-treated people living with HIV to HIV-negative control participants, and to investigate the relationship between neuroinflammation, synaptic density, and cognitive impairment in HIV.

PI_NAMEs: SPUDICH, SERENA S (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Address;Age;Animal Model;antiretroviral therapy;Autopsy;Binding;Biological;Biological Markers;Blood;Brain;brain dysfunction;brain tissue;Central Nervous System;cerebral atrophy;Cerebrospinal Fluid;Chronic;Clinical;clinical translation;Complex;Data;density;Disease;Enrollment;Ethnic Origin;Etiology;frontal lobe;Functional disorder;Future;Gender;glial activation;Glycoproteins;Goals;Hippocampus;HIV;HIV encephalitis;HIV Seronegativity;HIV-associated neurocognitive disorder;Homeostasis;Human;Image;imaging agent;imaging biomarker;immunoreactivity;Impaired cognition;Impairment;improved;Inflammation;Injury;Intervention;Intervention Studies;Investigation;Laboratories;Learning;Ligands;Measures;Mediating;Membrane Proteins;Memory;Methodology;Microglia;mild neurocognitive impairment;Modeling;Molecular;Monitor;multimodality;Nervous System Disorder;neural circuit;Neurocognitive;Neuroimmune;neuroinflammation;Neurologic;neurological pathology;neuron loss;Neuronal Injury;Neuropathogenesis;neuropathology;novel;novel therapeutic intervention;Organ;Outcome;parallel processing;Participant;Pathology;Persons;Pilot Projects;Population;Positron-Emission Tomography;presynaptic;presynaptic neurons;Presynaptic Terminals;programs;prospective;Proteins;radioligand;radiotracer;Recording of previous events;Research;Research Priority;Role;Sampling;Scanning;Structural defect;substance use;Synapses;Synaptophysin;therapeutic target;Tracer;treatment effect;Vesicle;Viral;white matter

PROJECT_TITLE: PET IMAGING OF SYNAPTIC DENSITY COMBINED WITH NEUROIMMUNOLOGIC MEASURES TO REVEAL MECHANISMS OF HIV NEUROPATHOGENESIS DURING ART


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Protein-protein interactions (PPIs) are very important in biology yet have been hard to study with selective small- molecule probes. In particular, there are few systematic methods to stabilize an individual PPI. For drug discovery, stabilization could be as important as inhibition; for chemical biology, stabilization offers much greater specificity, allowing us to study the role of a single PPI in a complex network. For example. 14-3-3 proteins alter the function of hundreds of proteins, regulating major signal-transduction pathways, transcription factors, and cell-cycle progression. In this project, we will develop protein-protein stabilization approaches that will allow us to prospectively target specific 14-3-3/client complexes with drug-like molecules. These PPI stabilization methodologies could be extended to other PPI networks and to inducing non-native complexes to create new functions.

PI_NAMEs: ARKIN, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Adaptor Signaling Protein;Address;Binding;Binding Proteins;Binding Sites;Biological;Biological Models;Biological Process;Biology;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation Pathway;Cells;Cellular Assay;Chemicals;Client;Complex;design;Development;Disease;Disulfides;drug discovery;drug-like compound;enzyme activity;ESR1 gene;Estrogen Receptors;estrogen-related receptor;flexibility;FOXO1A gene;fusicoccin;Genetic Transcription;Glues;Goals;Homodimerization;Human;immune modulating agents;Individual;inhibitor;insight;iterative design;Knowledge;Learning;Length;Link;Malignant Neoplasms;Methodology;Methods;Modification;Molecular;Molecular Conformation;Multiprotein Complexes;Natural Products;Nature;Nerve Degeneration;non-Native;novel;novel therapeutics;Outcome;Peptides;Pharmaceutical Preparations;Phosphopeptides;Phosphorylation;Phosphotransferases;Physiological Processes;Play;Positioning Attribute;prospective;Protac;protein complex;Protein Isoforms;protein protein interaction;Proteins;Proteome;proteostasis;raf Kinases;rare genetic disorder;Role;scaffold;Scaffolding Protein;screening;Serine;Signal Transduction;Signal Transduction Pathway;Site;small molecule;Specificity;Structure;Surface;synthetic protein;System;Technology;Testing;Therapeutic;Threonine;tool;transcription factor;Transcriptional Regulation;Translating;ubiquitin ligase

PROJECT_TITLE: Systematic stabilization of specific protein-protein interactions


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Obese children are more likely to experience psychological distress and social isolation in the short term, and are more likely to become obese adults with heightened associated disease burden. Prevalence of obesity is high among children in low-income and minority populations, and it is these very populations that are suffering most from COVID-19. Our study of the impact of the prolonged school closures mandated by COVID-19 on weight status of low-income children and the mitigating potential of emergency food programs promises findings critical to safeguarding the health of this generation of children as well as making effective policy with respect to disease prevention and disaster preparedness.

PI_NAMEs: OHRI-VACHASPATI, PUNAM  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;adult obesity;Affect;Authorization documentation;Body mass index;burden of illness;Catchment Area;Characteristics;Child;Cities;Communities;community-level factor;Coronavirus;coronavirus pandemic;cost;COVID-19;COVID-19 impact;COVID-19 pandemic;current pandemic;Data;Data Collection;delivered meals;Dietary Practices;Dimensions;Disasters;disorder prevention;Electronics;Elements;Eligibility Determination;Emergency Situation;energy balance;Environment;excessive weight gain;experience;falls;Family;feeding;Food;Food Assistance Programs;food insecurity;Food Safety;Funding;Future;Generations;Health;Height;improved;Interruption;K-12 student;Knowledge;Length;Literature;Long-Term Effects;Low income;lower income families;Measurement;Measures;Minority Groups;New Jersey;Nurses;Nutritional;Obesity;obesity in children;operation;Outcome;pandemic disease;Parents;Physical activity;Policies;Population;post-COVID-19;Prevalence;Price;programs;protective effect;psychological distress;Qualifying;Readiness;Research;response;safety net;school closure;School Enrollments;school reopening;Schools;sedentary;Social isolation;Structure;Students;Time;Time Series Analysis;trend analysis;Unhealthy Diet;United States Department of Agriculture;United States National Institutes of Health;Weight;Weight Gain;Weights and Measures

PROJECT_TITLE: The impact of COVID-19 related school closures on children's weight status


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Lung;Machine Learning and Artificial Intelligence;Orphan Drug;Precision Medicine;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative In this proposal, we will identify proteins that predict different rates of progression in patients with idiopathic pulmonary fibrosis. Using protein data, we will also develop a protein signature to predicts near-term changes in lung function, which could speed drug development by reducing the number of patients needed for an idiopathic pulmonary fibrosis clinical trial.

PI_NAMEs: OLDHAM, JUSTIN M (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;antifibrotic treatment;Biological;Biological Markers;biomarker driven;biomarker identification;biomarker signature;Blood;Categories;Cessation of life;Characteristics;Clinical Trials;clinically actionable;cohort;Collaborations;Custom;Data;Data Science;Development;drug development;Ensure;experience;Fibrosis;fibrotic interstitial lung disease;Foundations;Funding;Geography;Goals;Heterogeneity;idiopathic pulmonary fibrosis;innovation;Interstitial Lung Diseases;Investigation;Knowledge;Linear Regressions;Lung Transplantation;Machine Learning;Malignant Neoplasms;Mediator;Methodology;Modeling;Molecular;mortality;National Heart, Lung, and Blood Institute;new therapeutic target;nintedanib;novel;novel marker;novel therapeutics;Outcome;Patients;performance tests;Pharmaceutical Preparations;Phase III Clinical Trials;Phenotype;Pirfenidone;Plasma;pointed protein;Positioning Attribute;precision medicine;predictive marker;Progressive Disease;prospective;Proteins;proteomic signature;Proteomics;Publishing;Pulmonary Fibrosis;pulmonary function;pulmonary function decline;recruit;Registries;Research;Research Personnel;Resources;Sample Size;Speed;Technology;tool;treatment effect;treatment group;Validation;Vital capacity;Work

PROJECT_TITLE: Proteomic Profiling of Idiopathic Pulmonary Fibrosis Progression Trajectory

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: RELEVANCE TO PUBLIC HEALTH This project is relevant to public health because it directly addresses gaps in the bioscience/medical workforce pipeline, particularly with respect to the participation of minority and under-represented communities. The innovative three-phase program 1) integrates in-school instruction in the high level bioscience competencies required for 21st century careers and extensive exposure to different careers with 2) online dual-enrollment courses that demystify the college experience as well as providing guidance in the skills and strategies needed for independent learning while 3) providing an intensive residential career awareness program with near-peer mentor support. The program includes training for teachers implementing the material and for the near-peer mentors who will interact with the students, and will thus help students master critical health-related subject matter, develop their scientific reasoning skills, health literacy and increases their awareness of science and health care careers so they can make informed career choices.

PI_NAMEs: JACQUE, BERRI H (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Adult;Antimicrobial Resistance;Awareness;Biological Sciences;Biotechnology;Boston;career;career awareness;Career Choice;Career Exploration;Case Study;Clinical Trials;cohort;college;Commerce;Communities;Compensation;Competence;Degree requirements;demographics;design;Disease;Drug Design;Dual Enrollment;E-learning;educational atmosphere;Educational Curriculum;Educational process of instructing;Educational workshop;Effectiveness;eleventh grade;Ethnic Origin;Evaluation;expectation;experience;Exposure to;Financial Support;Fostering;Gender;Goals;Grant;Health;health literacy;Healthcare;high school;High School Student;HIV;Human;improved;Infrastructure;innovation;Instruction;Internships;Interruption;Laboratories;Learning;Learning Skill;lens;Massachusetts;Medical;medical schools;Medicine;Mentors;Minority;Minority Participation;minority undergraduate;model development;Modeling;novel;Occupations;online course;online resource;Outcome;Participant;peer coaching;Phase;Population;Preparation;Problem Solving;programs;prototype;Public Health;Readiness;Resources;role model;Role playing therapy;Rural Community;Scholarship;School Teachers;Schools;Science;Scientist;Self Efficacy;self-directed learning;Series;skills;STEM career;STEM field;student participation;Students;success;Talents;teacher;Teacher Professional Development;Teaching Materials;Technology;Testing;Thinking;Time;Time Management;tool;Training;Translating;twelfth grade;undergraduate student;Universities;Urban Community;wasting

PROJECT_TITLE: The Great Diseases: Bridging biomedical career exploration, competency building and mentoring

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Hematology;Immunotherapy;Lung;Lung Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: AUGUSTA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Public health narrative This study will focus on understanding the biological mechanisms and clinical implications of the CD73- adenosinergic checkpoint in head and neck cancer on tumor progression and following radiotherapy, which greatly impacts patient survival. This study is highly relevant to human health and the results obtained in this study will lead to the rapid development of translational strategies to improve cancer treatment and maximize therapeutic gains.

PI_NAMEs: CUI, YAN  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: 5'-Nucleotidase;Adenosine;ADORA2A gene;advanced disease;Affect;Alcohol consumption;Biological;Cancer Model;cancer therapy;Carcinogens;Cell Death;Cell surface;Cells;chemoradiation;Clinical;Clinical Research;cohort;CTLA4 gene;Dendritic Cells;Development;Disease Progression;Enzymes;Evolution;extracellular;Fibroblasts;Genetically Engineered Mouse;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Health;high dimensionality;Human;Hypoxia;Immune;immune checkpoint;immune checkpoint blockade;immunosuppressed;Immunosuppression;improved;Individual;insight;Lead;Leukocytes;Link;Macrophage;malignant mouth neoplasm;Malignant Neoplasms;Mediating;Modality;Modeling;Mouse Strains;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Myeloproliferative disease;Natural Killer Cells;neoplastic cell;oral HPV-positive head and neck cancers;oral tissue;Outcome;Pathway interactions;patient subsets;Patients;Pattern;PD-1/PD-L1;peripheral blood;Postoperative Period;pre-clinical;Pre-Clinical Model;Productivity;Public Health;Purinergic P1 Receptors;Radial;Radiation therapy;receptor;Receptor Cell;Regimen;Role;Sampling;small molecule inhibitor;spatial relationship;Specimen;T-Cell Activation;T-Lymphocyte;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;therapy outcome;Tobacco use;Tongue;tool;Toxic effect;translational approach;tumor;Tumor Immunity;tumor microenvironment;tumor progression;tumor-immune system interactions;Validation

PROJECT_TITLE: Targeting the CD73-adenosinergic pathway in head and neck cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Neurosciences;Opioids;Substance Misuse

ORG_CITY: SOLNA

ORG_COUNTRY: SWEDEN

ORG_FIPS: SW

ORG_NAME: KAROLINSKA INSTITUTE

PHR: NARRATIVE Alcohol use disorder (AUD) is a serious condition, which we study in a rat model and in cell culture. We search conditions for prevention of relapse with the approved drug naltrexone mainly acting on the enkephalin/MOP receptor and with agents acting on the dynorphin/KOP receptor systems. Comprehensive analysis of changes in circuitry in the central nucleus of the amygdala are guided by super-resolution imaging and mechanistic studies at a molecular level.

PI_NAMEs: MARTIN-FARDON, REMI ;TALISMAN, TIJANA ;TERENIUS, LARS Y (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Abstinence;Acute;Affect;Alcohol abuse;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol use disorder;Amygdaloid structure;Animal Behavior;Animal Model;Animals;antagonist;Attenuated;Autopsy;Behavioral;behavioral phenotyping;Binding;Binding Sites;Brain;brain tissue;Cell Culture Techniques;Cell membrane;Cell Nucleus;Cells;Chronic;Clinical;clinical effect;clinical examination;Clinical Trials;Complex;Country;craving;Cytoskeleton;Data;Dependence;Dose;Drug Targeting;Dynorphins;Elements;Enkephalins;epidemiology study;Ethanol;Ethanol dependence;FDA approved;Fluorescence;fluorescence imaging;Fluorescence Spectroscopy;Future;Gene Expression;Genes;Genetic Polymorphism;Genotype;Global Change;hedonic;Homo;Imaging Techniques;Immunohistochemistry;In Situ;indexing;Individual;insight;interest;Investigation;kappa opioid receptors;Lateral;Length;Life;life span;Lipids;Medical;Membrane;Membrane Microdomains;Mental Depression;Microscopy;Modeling;Molecular;mu opioid receptors;Naltrexone;nanoscale;Negative Reinforcements;Neurons;neuropsychiatry;novel;Opioid;Opioid Antagonist;Opioid Receptor;personalized medicine;Pharmaceutical Preparations;Pilot Projects;prevent;Proteins;Publishing;Rattus;Reaction;receptor;Receptor Signaling;Recording of previous events;Relapse;relapse prevention;Resolution;Scandinavian;self organization;Signal Transduction;single molecule;social;Societies;Specimen;Spectrum Analysis;superresolution imaging;superresolution microscopy;System;Techniques;Technology;Testing;Time;tissue preparation;trafficking;Transcript;translational approach

PROJECT_TITLE: Drug targeting the dynamics of opioid systems in alcohol dependence

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]