NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Genomic information largely flows from DNA to RNA to protein. This project will employ computational strategies to better predict protein level changes from mRNA measurements. We believe the results will have strong potential to further improve the utility of functional genomics experiments to assess gene expression output across biomedical research fields.

PI_NAMEs: LAU, EDWARD  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Amino Acid Sequence;Area;Base Sequence;Biological;Biological Factors;Biological Process;Biomedical Research;Cells;Code;cohort;Data;deep learning;design;differential expression;Dimensions;Disease;DNA;Engineering;experimental study;feature selection;functional genomics;Future;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene interaction;Gene Targeting;Genes;Genome;Genomics;Goals;gradient boosting;Immunoassay;improved;In Vitro;insight;knock-down;Knowledge;Language;Learning;learning strategy;machine learning method;Mass Spectrum Analysis;Measurement;Measures;Messenger RNA;Methods;model building;Modeling;Molecular;mRNA sequencing;Neighborhoods;Output;Performance;Post-Transcriptional Regulation;pre-trained model;predictive modeling;Prevalence;protein protein interaction;Proteins;Proteome;Proteomics;Proxy;random forest;Research;Research Personnel;RNA;Sampling;self supervised learning;Software Tools;Structure;supervised learning;System;Techniques;Technology;Time;tool;Transcript;transcriptome;transcriptomics;Translating;Translations;Validation;vector;wasting;web app;Western Blotting;Work

PROJECT_TITLE: Feature Engineering to Infer Proteomic Changes from mRNA Data

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: OD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics

ORG_CITY: KINGSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE Mitochondrial dysfunction (MD) is common to several human diseases including non-alcoholic liver disease and diabetes as well as aging and age-related diseases. Currently, the role of MD in the etiology of such diseases has not been clearly determined. The purpose of this proposal is to characterize a new mouse model where we can finely tune MD in single tissues at specific developmental stages to more accurately investigate how single tissues react and cope with MD in health and disease states.

PI_NAMEs: COPPOTELLI, GIUSEPPE ;ROSS, JAIME MARIE (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: absorption;ACTA1 gene;Address;Affect;age-related disease;Aging;aging brain;aging related;Alopecia;Alzheimer's disease related dementia;Anemia;Animal Model;Apoptosis;Auditory;Behavioral;Biochemical;Bioenergetics;Body Weight decreased;brain health;Cardiovascular Diseases;Caring;Catalytic Domain;Cause of Death;Cell Nucleus;Cells;Cessation of life;Chronic;Citrate (si)-Synthase;Cognition;Compensation;coping;cost;Cre driver;Development;Diabetes Mellitus;Disease;disorder prevention;Embryo;Etiology;Excision;Family;Fatty acid glycerol esters;Fatty Liver;Financial Hardship;Functional disorder;Genomics;Goals;Health;Histologic;Homeostasis;Hospice Care;hospice environment;human disease;Impaired cognition;Impairment;Induced Mutation;inducible Cre;Inflammation;Insulin Resistance;interest;Knock-in;Knock-in Mouse;Knowledge;Kyphosis deformity of spine;Life;life span;Long-Term Care;LoxP-flanked allele;Malignant Neoplasms;Mediating;Metabolic;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;Modeling;Molecular;mouse model;Mus;Muscle;Myopathy;Nervous System Disorder;non-alcoholic fatty liver disease;novel;novel therapeutic intervention;Obesity;Organ;Osteoporosis;Oxidative Phosphorylation;Pathology;Persons;Phenotype;Play;Polymerase;Reaction;Regulation;Resources;Role;sarcopenia;Scientist;senescence;social;Stains;subcutaneous;System;Testing;Therapeutic;Time;Tissues;United States;Visual;Work;World Health Organization

PROJECT_TITLE: Novel Knock-in mtDNA Mouse Model to Study Mitochondrial Dysfunction

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric

ORG_CITY: BERKELEY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative The spatial and temporal coordination of gene transcription is crucial to ensure that fundamental biological processes, such as embryonic development, are successfully orchestrated, thereby allowing for the normal functioning of an organism. By leveraging an endemic group of pupfishes from the Bahamas, which exhibit extremely divergent craniofacial morphologies, I propose a multi-omics approach to unravel and functionally test the gene networks and regulatory regions of the genome controlling changes in gene expression underlying their naturally divergent craniofacial development.

PI_NAMEs: PALOMINOS CHACON, MARIA FERNANDA  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Adult;Affect;African;Alleles;Alternative Splicing;ATAC-seq;Bahamas;base;Binding;Biological Models;Biological Process;Candidate Disease Gene;career;CCRL2 gene;Cell Proliferation;cell type;Chondrocytes;Chromatin;Chromatin Structure;CISH gene;clinically relevant;Complex;craniofacial;craniofacial development;CRISPR/Cas technology;Cyprinodons;Cyprinodontidae;Data;Development;differential expression;Disease;Disparate;Disparity;egg;Elements;Embryo;Embryonic Development;Evolution;Exhibits;feeding;First Pharyngeal Arch;Fishes;Gene Expression;gene interaction;gene network;gene regulatory network;Gene Transfer Techniques;General Practitioners;Genes;Genetic;Genetic Polymorphism;Genetic study;Genetic Transcription;Genome;genome-wide;genome-wide analysis;Genomics;Genotype;Growth;hatching;Head;Human;Human Biology;human disease;In Situ Hybridization;Island;Jaw;Laboratories;Larva;Life;Link;Mandible;Maxilla;Meckel's cartilage;Modeling;Morphogenesis;Morphology;multiple omics;Muscle;mutant;Mutation;novel;Nuclear;Nucleic Acid Regulatory Sequences;Oral;Organism;Phenotype;Post-Transcriptional Regulation;Postdoctoral Fellow;predictive modeling;Probability;Process;Production;programs;Proteins;Radiation;Reaction;Regulation;Regulatory Element;Reporting;Research;Route;segregation;spatiotemporal;Specialist;Spliced Genes;Structure;Sum;System;Tail;teleost fish;Testing;Time;Tissue-Specific Gene Expression;Tissue-Specific Splicing;Tissues;Tooth structure;transcription factor;transcriptome;transcriptome sequencing;Variant;Vertebrates;Work

PROJECT_TITLE: Novel gene regulatory networks underlying two specialized modes of craniofacial development in a new model system of pupfishes

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND

PHR: PROJECT NARRATIVE Children born very preterm are at increased risk for poor neurodevelopmental outcomes including specific deficits in attention and executive function that may limit their long-term health and potential. This proposal aims to understand whether variations in caregiving quality (e.g., caregiver sensitivity and structuring) are associated with attention and executive function outcomes in very preterm children at school age, a critical yet understudied developmental period. The knowledge to be gained from this proposal has direct public health benefits as it could improve identification of preterm children at highest risk for cognitive deficits and provide information regarding modifiable caregiver behaviors that could serve as future intervention targets.

PI_NAMEs: CAMEROTA, MARIE  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Academic achievement;Academic support;Address;adverse outcome;Age;Attention;Attention deficit hyperactivity disorder;Award;Behavior;Birth;Caregivers;caregiving;Child;Child Development;Child Health;Code;Cognitive;Cognitive deficits;cognitive development;cohort;cost;Cues;Data;Development;Developmental Process;Dimensions;Environmental Risk Factor;Executive Dysfunction;executive function;extreme prematurity;Family;Family Characteristics;Funding;Future;Gestational Age;Health;Health Benefit;high risk;Impaired cognition;Impairment;improved;Incidence;infancy;Infant;Intervention;intervention effect;Investigation;Knowledge;Life;Link;Low Birth Weight Infant;low socioeconomic status;Measures;Medical;Morbidity - disease rate;National Institute of Child Health and Human Development;Neonatal;neurobehavior;neurobehavioral;Neurodevelopmental Deficit;Neurodevelopmental Disorder;novel;Nursery Schools;Outcome;Parents;peer;performance based measurement;Phenotype;Population;Predisposition;Pregnancy;Premature Birth;Premature Infant;prevent;programs;prospective;protective factors;Protocols documentation;psychological distress;Public Health;Recording of previous events;recruit;Research;Resources;Risk;Risk Factors;Role;Sampling;scaffold;School-Age Population;Schools;skills;Strategic Planning;Structure;Testing;theories;Time;United States National Institutes of Health;Variant;Visit;Work

PROJECT_TITLE: Caregiving Influences on Attention and Executive Function in Children Born Very Preterm

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: CHARLESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE Polyploid cancer cells have emerged as a dangerous subpopulation of tumor cells but remain poorly characterized. This proposal seeks to identify genes that allow this subpopulation to arise and form daughter cells and to use archived, de-identified samples from ovarian cancer will be analyzed for putative markers of polyploid cancer cells. Results from this project serve as a foundation for detection of polyploid cancer cells in cancer specimen and to develop novel therapies aimed at eliminating this population or the formation of daughter cells.

PI_NAMEs: DELANEY, JOE R;VOELKEL-JOHNSON, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Adjuvant Chemotherapy;Aneuploidy;Angiogenesis Inhibitors;Archives;bevacizumab;Biogenesis;Bioinformatics;Biological Markers;cancer cell;Cancer Patient;Cell Line;Cell Nucleus;Cells;Characteristics;chemotherapy;Chromosomal Instability;Chromosomes;Clinical;CRISPR screen;CRISPR/Cas technology;Cytoplasm;Dangerousness;Data;daughter cell;Detection;Doxorubicin;driving force;drug development;Environment;Essential Genes;Event;Exhibits;experimental study;Exposure to;Foundations;Future;galactosylgalactosylglucosylceramidase;Generations;Genes;Genetic;Genome;Heterogeneity;Histologic;Human;Immunohistochemistry;improved;improved outcome;interest;KDR gene;Knock-out;Knowledge;Laboratories;Lesion;Life Cycle Stages;Maintenance;Malignant - descriptor;Malignant neoplasm of ovary;Malignant Neoplasms;Melanoma Cell;Methods;Molecular;Molecular Abnormality;Morphology;Mothers;Mutation;N-palmitoylsphingosine;Nature;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;novel therapeutics;Operative Surgical Procedures;Ovarian;Ovarian Serous Adenocarcinoma;participant enrollment;Pathologist;Patients;Pharmaceutical Preparations;Platinum;Ploidies;Polyploid Cells;Polyploidy;Population;Prevalence;prevent;Prognosis;prognostic;Prognostic Marker;protein biomarkers;Proteins;Protocols documentation;Regulation;repaired;Resistance;Role;Sampling;screening;senescence;Serous;Solid;Solid Neoplasm;Specimen;Stains;Stress;synergism;taxane;therapeutic target;therapy outcome;therapy resistant;TP53 gene;transcriptome sequencing;tumor;Tumor Debulking;tumor initiation;whole genome;Work

PROJECT_TITLE: Identification of essential biomarkers in the polyploid cancer cell lifecycle

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-5 (M1)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Kidney Disease;Pediatric;Sepsis

ORG_DEPT: PEDIATRICS

ORG_STATE: CO

PHR: Patients who develop sepsis-associated acute kidney injury have high rates of morbidity and mortality and there are no effective treatment options for this disease. We will prospectively enroll critically ill children and leverage multiple clinical trials of critically ill adults and children to further investigate a potential mechanism (complement activation) that causes this disease and gain mechanistic insight into site and extent of complement activation. This proposal will inform future clinical trials in critically ill children and adults with sepsis by identifying treatment windows and stratification levels for predictive enrichment for a future interventional trial testing a therapeutic complement inhibitor.

PI_NAMEs: STENSON, ERIN K (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acute Kidney Tubular Necrosis;Acute Renal Failure with Renal Papillary Necrosis;Address;Admission activity;Adult;age related;Ancillary Study;bactericide;Binding;biobank;Biological Assay;Biological Markers;Biology;Biometry;Biopsy;Bolus Infusion;career;career development;Cells;Child;Childhood;Chronic Kidney Failure;Clinical Research;Clinical Trials;Cohort Studies;Colorado;Complement;Complement Activation;Complement Factor B;Complement Inactivators;Conduct Clinical Trials;Creatinine;Critical Care;Critical Illness;Critically ill children;Cytolysis;Data;Death Rate;Dedications;Deposition;Development;Development Plans;Diagnosis;Dialysis procedure;Disease;effective therapy;Emergency Situation;Enrollment;Environment;Epithelial Cells;Evaluation;Event;experience;FDA approved;Foundations;Future;Goals;Grant;Hour;Immune response;improved outcome;inhibitor;Injury;innovation;insight;Intensive Care Units;Intervention Trial;Isotonic Solutions;K-Series Research Career Programs;Kidney;Knowledge;Liquid substance;Manuscripts;Measures;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methods;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Multicenter Trials;multidisciplinary;Mus;Nephrology;Organ;Organ failure;Outcome;Pathogenesis;Pathway interactions;patient oriented research;patient stratification;Patients;Pediatric Hospitals;pediatric sepsis;Physicians;Pilot Projects;pilot trial;Play;Positioning Attribute;Preparation;prevent;professor;prognostic;programs;prospective;Prospective, cohort study;Publications;Publishing;Randomized;randomized placebo controlled trial;recruit;Renal tubule structure;Research;Role;Scientist;Sepsis;septic;septic patients;Severities;Site;skills;Stratification;targeted treatment;Testing;Therapeutic;Therapeutic Trials;Therapeutic Use Study;Time;Training;Translating;Tubular formation;United States;Urine;Wild Type Mouse;Work;Writing

PROJECT_TITLE: Complement Activation in Sepsis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: FORT COLLINS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: PROJECT NARRATIVE This Career Development Award proposal centers around examination of how thermal stress affects arbovirus- vector-host interactions, with a focus on antiviral immunity and inflammation in the host. The objectives of this study are to (1) develop a Chiropteran model for assessing innate immunity and inflammasome activation in bats exposed to thermal stress; (2) characterize host-vector interactions and host immune response following intradermal inoculation of bats with mosquito salivary gland extract (3) quantify ZIKV infection dynamics at different temperatures in bat cell lines. The anticipated results will contribute to ecoimmunology and arbovirology studies by expanding our understanding of how heat stress impacts bat immunology and the dynamics of arbovirus- vector-host interactions.

PI_NAMEs: FAGRE, ANNA  (contact)

PROJECT_TERMS: Aedes;Affect;Animal Model;Animals;Anti-viral Response;antiviral immunity;Arbovirus Infections;Arboviruses;Area;Arthropod Vectors;Attention;Award;Biomedical Research;Bite;Body Temperature;career;career development;Cell Line;Cells;Characteristics;Chiroptera;climate change;Clinical;Communities;comparative;Complex;Culicidae;Cutaneous;Data;Dedications;Development;diagnostic biomarker;Disease;Ecological Change;Environmental Health;Environmental Impact;Epidemiology;Euthanasia;experience;Exposure to;Faculty;Foundations;Fruit;Funding;Geography;Heart Rate;Heat shock proteins;Heat Stress;Immune;Immune response;Immunity;Immunologics;Immunology;Immunosuppression;Implant;In Vitro;in vivo;Infection;Inflammasome;Inflammation;Inflammatory Response;Injections;Innate Immune System;Jamaican;K-Series Research Career Programs;Kinetics;Knowledge;land use;Leukocytes;mast cell;Mentorship;metabolomics;Methodology;Methods;migration;Modeling;Molecular Chaperones;Monitor;multiple omics;Natural Immunity;novel;Outcome;pathogen;Pathology;Pathway interactions;Physiologic pulse;Physiological;Physiology;Population;Positioning Attribute;Predisposition;programs;protein function;Proteomics;Public Health;recruit;Regulation;Reproduction;Research;Research Personnel;response;Role;Salivary Glands;Stains;Stress;Study models;subcutaneous;System;Taxonomy;Technology;Temperature;tenure track;thermal stress;Time;time use;tissue culture;Training;transcriptomics;transmission process;vector;Viral;Virus;Virus Diseases;virus host interaction;Virus Replication;Work;Zika Virus;ZIKV infection

PROJECT_TITLE: Developing a Chiropteran model to study the impact of thermal stress on antiviral immunity and inflammatory responses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-J (80)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: ImmunoPET is an emerging non-invasive imaging technique that can fulfill the promise of in vivo pathology assessment. This proposal leverages advances in lipid nanoparticle technology to synthesize immunoPET probes with optimized pharmacokinetics and to identify the ideal LNP administration strategy in patients. Successful execution of this project will lead to a revolutionary, streamlined and modular platform for immunoPET molecular imaging/therapy that is immediately testable in patients.

PI_NAMEs: NG, SHEUNG CHEE THOMAS  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Address;Adoption;Affect;Antibodies;Benchmarking;Binding;Bioreactors;Bispecific Antibodies;chelation;Chemicals;Clinical;clinical imaging;clinical translation;Complex;COVID-19 pandemic;Development;Disease;Drug Kinetics;Equity;Exhibits;FDA approved;FOLH1 gene;Goals;Half-Life;Healthcare Systems;Hospitals;Human;Image;imaging agent;imaging capabilities;imaging facilities;imaging probe;Imaging Techniques;Immune;Immunoglobulin Fragments;Immunohistochemistry;ImmunoPET;improved;in vivo;Individual;Infection;Inflammation;Injectable;Intravenous;intravenous administration;intravenous injection;Investigation;Kinetics;Label;lipid nanoparticle;Malignant Neoplasms;manufacture;Mediating;Messenger RNA;Mind;Modeling;molecular imaging;mouse model;mRNA Expression;Mus;non-invasive imaging;novel;optical imaging;Pathology;Pathway interactions;patient population;Patients;Pharmacology;Pharmacy facility;Population;Positron-Emission Tomography;primary care setting;Production;prostate cancer model;Proteins;Radiation Toxicity;Radioimmunoconjugate;Radioisotopes;Radiolabeled;radiotracer;Resources;Route;Self Administration;Signal Transduction;small molecule;socioeconomic disadvantage;Staging;subcutaneous;supply chain;System;targeted imaging;Techniques;Technology;Therapeutic;therapeutic protein;Time;Tissues;Tracer;translational impact;Translations;tumor;uptake;Validation;virtual monitoring

PROJECT_TITLE: Optimized and accessible immuno-PET using lipid nanoparticle-mediated in vivo bioreactor

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative: The proposed research addresses a significant health inequity among children (asthma morbidity) with innovative approaches and will result in a sophisticated machine learning model to identify children at highest risk of morbidity, an engaged community advisory board of caregivers of children with asthma, and critical pilot data on the feasibility and acceptability of an integrated social and asthma care intervention. This work aligns with the NHLBI’s Objective 3 (understanding causes of and identifying strategies to effectively address population health disparities) and 7 (leveraging emerging opportunities in data science to open new frontiers in heart, lung, blood, and sleep disorders). The results of this proposal may enable early identification of children with asthma at risk for hospitalization and a family-centered and caregiver-endorsed integrated social and asthma care intervention which, when paired together, has the potential to improve health equity and reduce morbidity among children with asthma.

PI_NAMEs: TYRIS, JORDAN  (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Absenteeism;acceptability and feasibility;Accounting;Achievement;Address;Adult;Affect;Area;Asthma;barrier to care;Black race;Calibration;career;career development;Caregivers;Caring;Child;Child Care;Child Health;Childhood;Childhood Asthma;Chronic;Clinic Visits;Clinical;Clinical Trials Design;Communities;community advisory board;community engagement;Complex;Data;Data Science;design;Development Plans;Disparity;disparity reduction;District of Columbia;Early identification;Education;Educational process of instructing;Effectiveness;efficacy evaluation;Emergency department visit;Employment;Environment;experience;Family;Focus Groups;frontier;Funding;Future;Goals;Growth;Health;health disparity;health disparity populations;health equity;health equity promotion;health inequalities;Health Services Accessibility;Healthcare;Heart Diseases;Hematological Disease;high risk;high school;Hispanic;Home;Hospitalization;Hospitals;improved;Individual;Inequity;innovation;interest;Intervention;Knowledge;literacy;Lung Diseases;Machine Learning;machine learning method;machine learning model;Medical;Mentored Clinical Scientist Development Program;Mentors;Methodology;Methods;Modeling;Morbidity - disease rate;National Heart, Lung, and Blood Institute;Non-linear Models;Outcome;outcome disparities;patient oriented research;Pharmaceutical Preparations;population based;Psychosocial Stress;Quality of life;Randomized, Controlled Trials;recruit;Registries;Research;Research Design;Research Methodology;Research Personnel;Research Proposals;Resources;Risk;risk prediction;Shapes;Sleep Disorders;social;social adversity;social factors;social health determinants;statistics;Surveys;telehealth;Testing;therapy design;Training;Translating;Universities;Washington;Work;Youth

PROJECT_TITLE: Family-centered integration of social and medical care to promote health equity among children with asthma

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (MA)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative: Associations between malaria-transmitting Anopheles mosquitoes and Wolbachia bacteria are both rare in nature and challenging to establish in laboratory settings, precluding the utility of Wolbachia in malaria control. It is not understood why Anopheles seem to be largely incompatible with Wolbachia infections, despite these bacteria infecting an estimated 60% of insect species, including many other mosquitoes. In this proposal, I outline a plan to investigate the basis of this incompatibility and overcome it, while simultaneously pursuing an alternate use of Wolbachia-induced Cytoplasmic Incompatibility in a gene drive approach.

PI_NAMEs: ADAMS, KELSEY LEANNE (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Aedes;Affinity Chromatography;Anopheles gambiae;Anopheles Genus;Anti-malarials;Arbovirus Infections;Arboviruses;Area;Automobile Driving;Award;Bacteria;Biocontrols;Bioinformatics;Biological Process;Biology;Cells;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combat;Culicidae;Cytoplasm;Dengue Virus;Drosophila melanogaster;Embryo;endosymbiont;Engineering;Ensure;Equipment;experience;Failure;Female;female fertility;female reproductive tract;flexibility;Frequencies;functional genomics;Funding;gene drive system;Gene Expression;Gene Transfer Techniques;Generations;Genes;Genetic;Genetic Engineering;Genetic Induction;Genomics;Germ Lines;Human;Immune response;In Vitro;in vivo;Infection;Infertility;innovation;Insecta;insight;Knock-out;Knowledge;Laboratories;Link;Malaria;malaria mosquito;malaria transmission;male;Mass Spectrum Analysis;mathematical model;Mathematical Model Simulation;Medical;Mentors;Microinjections;Molecular;mosquito reproduction;mosquito-borne pathogen;Nature;novel strategies;Parasites;pathogen;Phase;Phenotype;Plasmodium;Plasmodium falciparum;Population;Positioning Attribute;Postdoctoral Fellow;predictive modeling;prevent;Public Health Schools;Reporting;reproductive;reproductive toxicity;Research;Research Personnel;Robotics;Role;Scientist;Shapes;skills;Specialist;Specificity;stem;System;Testing;Time;tool;Toxic effect;Training;transcriptome sequencing;Transgenes;transgenic insect;transmission process;Tropism;Variant;vector;vector control;vector-borne infection;viral transmission;Wolbachia;Work;Zika Virus

PROJECT_TITLE: Harnessing Wolbachia-induced conditional infertility for control of the malaria mosquito

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Genetics;Hematology;Nutrition;Obesity;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Millions globally are at risk of nutritional stress and these external signals serve as a potent regulator of human physiology and pathophysiology. It is largely unknown why sickle cell disease (SCD) presents with variable severity between patients. As much of the pathology in SCD is driven by neutrophils, we aim to evaluate how nutritional stress regulates neutrophils development, function, and contribution to SCD severity, with applications to other neutrophil-driven diseases.

PI_NAMEs: MACK, ETHAN ANDREW (contact)

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TERMS: Adolescent;Adult;Age;Atlases;Binding;Biological Assay;Biology;Birth;Blood Platelets;Blood specimen;Body mass index;Bone Marrow;Caloric Restriction;career development;Cell Adhesion Molecules;Cell Physiology;Cells;Characteristics;Child;cohort;comparison control;Computational Biology;cytokine;Data;Data Set;Development;Diet;Diet and Nutrition;dietary;dietary control;Disease;Disease Outcome;disease phenotype;early experience;Early identification;early life exposure;Endothelial Cells;Epigenetic Process;experience;Exposure to;extracellular;Faculty;Fat-Restricted Diet;Flow Cytometry;Functional disorder;Genetic;Genetic Diseases;Genetic Transcription;Goals;granulocyte;Granulopoiesis;Hematologist;Hematology;Hemoglobin concentration result;Hemolysis;high body mass index;High Fat Diet;Human;Immune;Immune system;Immunologist;Immunology;in utero;Inequity;Inflammation;Institutional Review Boards;Learning;Life;Malnutrition;Measures;Mediating;Mentors;mortality;mouse model;Mus;Mutation;Nature;neutrophil;Neutrophil Activation;new therapeutic target;novel;nutrition;Nutritional;Nutritional Study;Obese Mice;Overnutrition;Overweight;Pathogenesis;Pathology;Patients;Pediatric Hospitals;Pennsylvania;Philadelphia;Physicians;Physiology;Play;Population;postnatal;Pregnancy;Process;Production;progenitor;Regulation;Research;response;Risk;Role;Sampling;Scientist;Severities;Severity of illness;Shapes;Sickle Cell Anemia;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;skills;social;stem cell population;Stress;stressor;Stroke;Time;Tissues;Training;transfusion medicine;Translational Research;Universities;vascular injury;Weaning;Weight;Work

PROJECT_TITLE: The impact of diet on granulopoiesis, neutrophil function, and sickle cell disease pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (M3)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric

PHR: PROJECT NARRATIVE Neurodevelopmental disorders are common, affecting 3% of the global population; these conditions include global developmental delay/intellectual disability, epilepsy, and autism spectrum disorder and are collectively associated with significant healthcare costs for the many children and families affected. Interneuronopathies are becoming more widely recognized as an important cause of neurodevelopmental disorders, with Fragile X and autism both associated with interneuron impairment. This K08 proposal will elucidate both the mechanism and the timeline during which EIF4A2, a DEAD-box encoding gene and novel regulator of interneurons, alters interneuron development, providing direction for future investigations of interneuron-targeted therapeutics.

PI_NAMEs: DUNCAN, ANNA RUTH (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acute;Address;Advisory Committees;Affect;alpha Tubulin;autism spectrum disorder;Award;Biological Assay;Biological Models;Brain;Bromodeoxyuridine;calbindin;calretinin;career;career development;Cells;Child;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;confocal imaging;CRISPR/Cas technology;Cytoskeletal Proteins;Data;Development;Differentiation Antigens;Doctor of Philosophy;Drosophila genus;Electrophysiology (science);Epilepsy;Eukaryotic Initiation Factor-1;Eukaryotic Initiation Factors;Event;Family;Fertilization;Fragile X Syndrome;Functional disorder;Future;gain of function;gamma-Aminobutyric Acid;Generations;Genes;Genetic;Genetic Predisposition to Disease;global developmental delay;Goals;Health Care Costs;Hour;Image;Immunohistochemistry;Impairment;improved;In Situ Hybridization;in vivo;infant outcome;Intellectual functioning disability;International;Interneurons;Investigation;K-Series Research Career Programs;knock-down;Larva;Lead;loss of function;Mentors;Mentorship;Messenger RNA;migration;Modeling;Movement;Mus;Muscle hypotonia;mutant;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;neurogenetics;Neurons;novel;overexpression;Parvalbumins;Pathogenicity;Phenotype;Play;Poly(A) Tail;Population;postmitotic;Process;progenitor;Prosencephalon;protein expression;Proteins;Reporter;Research;Risk;RNA Helicase;Role;Scientist;Secondary to;Seizures;skills;Somatostatin;SOX6 gene;Stem Cell Development;stem cell differentiation;stem cells;Swimming;System;Tail;targeted treatment;Testing;timeline;Transgenic Organisms;Translational Repression;Translations;United States National Institutes of Health;Variant;Western Blotting;Zebrafish

PROJECT_TITLE: Understanding the Role of EIF4A2 in Neurodevelopment

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-B (02)]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Dissemination and Implementation Research;Health Services;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Telehealth

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Remote patient monitoring (RPM) data provides an opportunity to evaluate disease activity and progression and inform management, however the volume of data exceeds clinicians’ cognitive capacity. Clinical decision support (CDS) tools can address this issue by automating data processing and making the information available and actionable at the point of care. The proposed studies align with NHLBI priorities to leverage data science and optimize implementation research, and further aim to improve interstitial lung disease (ILD) care delivery and outcomes by: (1) identifying provider and health-system level barriers to a CDS tool informed by RPM data, (2) evaluating the performance of ILD-risk classification algorithms using RPM data (3) piloting an RPM-informed CDS tool to evaluate its implementation and effectiveness potential in ILD.

PI_NAMEs: FARRAND, ERICA DAVONNE (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;Adult;algorithm training;Algorithms;Area;arm;Artificial Intelligence;Automatic Data Processing;Award;Behavioral;Blood;care delivery;care outcomes;career;Caring;Chronic;Chronic Disease;Chronic lung disease;Classification;classification algorithm;Clinic;Clinical;clinical decision support;clinical decision-making;clinical practice;Clinical Trials;Cognitive;cognitive capacity;Complex;COVID-19 pandemic;Data;Data Science;Decision Making;design;digital health;digital intervention;digital tool;Disease;Disease Management;disease model;Disease Progression;disorder risk;Effectiveness;effectiveness/implementation study;Electronic Health Record;Ensure;Evolution;expectation;experience;Fellowship;Funding;Goals;health care delivery;health related quality of life;Health system;Healthcare;high risk;Human;Hybrids;implementation evaluation;implementation framework;implementation research;implementation science;implementation strategy;improved;Informatics;Infrastructure;Interstitial Lung Diseases;Intervention;Intervention Studies;Interview;Machine Learning;Maps;Mentored Clinical Scientist Development Program;Mentorship;Methodology;Methods;Modality;Modeling;Monitor;Multicenter Studies;National Heart, Lung, and Blood Institute;novel;novel strategies;Outcome;Output;Oxygen;Oxygen saturation measurement;Patients;Performance;personalized care;personalized management;Persons;Physicians;pilot trial;point of care;programs;Provider;provider-level barriers;Public Health Informatics;pulmonary function;Pulse Oximetry;remote assessment;remote monitoring;remote patient monitoring;Research;Research Activity;Research Design;Research Methodology;Research Priority;Research Support;Resources;Risk;ROC Curve;scale up;Scientist;skills;Spirometry;Structure;support tools;System;system-level barriers;telehealth;Testing;theories;therapy design;tool;Training;Training Activity;United States;uptake;usability;Visit;Work

PROJECT_TITLE: Remote Evaluation and Surveillance of Patients with Interstitial Lung Disease (RESPOND-ILD): Transforming ILD Care Delivery with Remote Monitoring


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Narrative Liver fibrosis, as a result of many chronic liver diseases, leads to liver decompensation and liver-related mortality. During liver injury, the hepatic stellate cells (HSCs), also known as perisinusoidal cells, transdifferentiate into proliferative, fibrogenic myoﬁbroblasts which are the primary source of liver fibrosis. The role of autophagy, a highly conserved cell degradation pathway, in HSC activation is ambiguous. We propose to revisit the role of autophagy in HSC activation and fibrogenesis using novel autophagy and metabolic assays.

PI_NAMEs: NIGHOT, PRASHANT  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Aging;Alcoholic Liver Diseases;antifibrotic treatment;autocrine;Autophagocytosis;Autophagosome;Biological Assay;Body Weight decreased;Bypass;Caloric Restriction;Cell Death;Cell Physiology;cell type;Cells;Cessation of life;chronic liver disease;Collagen;cytokine;Degradation Pathway;Deposition;Detection;Development;Disease;Exercise;exosome;Extracellular Matrix;Fasting;fibrogenesis;Fibrosis;Flow Cytometry;Foundations;Goals;Health;Hepatic Stellate Cell;Hepatocyte;hepatocyte injury;Inflammatory;inhibition of autophagy;insulin sensitivity;Intervention;Investigation;Knowledge;Light;lipid metabolism;Lipids;Liver;Liver diseases;Liver Fibrosis;liver injury;Liver parenchyma;Lysosomes;Manuscripts;Mediating;Mediator;Membrane;Metabolic;Metabolic dysfunction;metabolic profile;Metalloproteases;Metformin;Microtubule-Associated Proteins;Modification;Morphology;mortality;Myofibroblast;novel;Obesity;Oxidative Stress;Paracrine Communication;Play;prevent;Process;Profibrotic signal;Proteins;Public Health;Research;response;Role;Source;Steatohepatitis;Structure;Techniques;Therapeutic;timeline;Tissues;tool;transdifferentiation;Viral hepatitis;Visit

PROJECT_TITLE: Autophagy and Hepatic Stellate cells activation

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Cannabidiol Research;Cannabinoid Research;Childhood Obesity;Clinical Research;Complementary and Integrative Health;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Natural Products;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Substance Misuse;Therapeutic Cannabinoid Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Cannabis use is on the rise, yet pregnant people and parents may not be aware of the potential risks to their children. Our study will examine when and how early-life exposure to cannabis impacts childhood adiposity and cardiometabolic health. It is hoped that our study will add to the limited data on this topic and help to spur widespread public health messaging about the potential risks of using cannabis while pregnant.

PI_NAMEs: MOORE, BRIANNA F (contact)

PROGRAM_OFFICER_NAME: DRGONOVA, JANA

PROJECT_TERMS: 10 year old;5 year old;Adult;Affect;African American population;Animal Model;Automobile Driving;Awareness;Birth;Birth Weight;Black American;Brain;Breast Feeding;Cannabidiol;Cannabinoids;Cannabis;cannabis cessation;cardiometabolism;Child;Child Health;child protective service;Childhood;cohort;Colorado;Compensation;Data;Development;Diet;dietary;early life exposure;Environmental Exposure;epidemiologic data;epidemiology study;Exposure to;fasting glucose;Fatty acid glycerol esters;Fetal Development;Fetal Growth Retardation;fetal marijuana exposure;Fetus;Folic Acid;Future;Glucose;Glucose Intolerance;Goals;Growth;Health;Health Personnel;high body mass index;High Prevalence;Individual;Intake;Intervention;Joints;Knowledge;large datasets;Learning;Legal;Life;life span;Link;Low Birth Weight Infant;marijuana legalization;marijuana use;maternal serum;Measures;Metabolic;Metabolic Diseases;Modeling;novel;Nutrient;Obesity;obesity in children;obesity risk;offspring;Omega-3 Fatty Acids;Outcome;Pancreas;Parents;Patient Self-Report;Patients;Persons;Pilot Projects;Positioning Attribute;postnatal;Predisposition;Pregnancy;pregnant;prenatal;prenatal exposure;Property;protective factors;Public Health;rapid growth;Rattus;Recreation;recruit;Reporting;Research;response;Risk;risk mitigation;Sampling;Testing;Tetrahydrocannabinol;therapy design;Tobacco;tobacco exposure;Tobacco use;trait;trend;Umbilical Cord Blood

PROJECT_TITLE: Prenatal exposure to cannabis and child cardiometabolic health outcomes

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Systemic inequities permeate all aspects of society and negatively impacts the work environment. We will conduct a cluster randomized trial to test an intervention designed to promote inclusive excellence. We will follow participants for two years to assess the impact of the intervention. Additionally, we will study neuro responses before and after the intervention.

PI_NAMEs: IDOKO, RONALD ;RUBIO, DORIS M (contact);WHITE, GRETCHEN

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Academia;Academy;Address;Anxiety;Behavior;Behavioral;Biomedical Research;Black Populations;Centers for Disease Control and Prevention (U.S.);Charge;Climate;Cluster randomized trial;Cognitive;Communities;comorbidity;comparison intervention;Conscious;Control Groups;cost;Dedications;design;Diabetes Mellitus;Diagnosis;disability;Diverse Workforce;Education;empowerment;Equity;Ethnic Origin;Evidence based intervention;experience;Faculty;functional MRI scan;gender expression;Gender Identity;Goals;health disparity;Heart Diseases;Hypertension;improved;Inequity;Institution;Intervention;intervention delivery;knowledge base;Lead;Leadership;Medical;Mentors;neural;neural correlate;neurobehavioral;Neurobiology;organizational climate;Participant;participant interview;patient engagement;Persons;Policies;Postdoctoral Fellow;Process;professional atmosphere;programs;psychologic;Public Health;Publications;Qualitative Research;Race;Racial Equity;racism;Randomized;Randomized, Controlled Trials;Religion;Research;Resources;response;Risk;sex;Sex Orientation;Site;Site Visit;social;Socialization;Societies;Socioeconomic Status;Stimulus;Structure;System;Testing;Text;therapy design;Thinking;Training;unconscious bias;Unconscious State;Universities;Waiting Lists;web site;Work

PROJECT_TITLE: Promoting Inclusive Excellence

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-W (RI)]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Diabetes;Genetics;Human Genome;Immunization;Immunotherapy;Patient Safety;Pediatric;Precision Medicine

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Antibody and antibody fusion protein therapies may halt loss of endogenous insulin production in recently- diagnosed Type 1 Diabetes (T1D) through Fc gamma receptor (FcγR)-associated mechanisms. The goals of this proposal are: 1) to identify genetic variants in FcγR loci that associate with therapeutic efficacy in completed T1D immunotherapy trials and 2) to evaluate the impact of associated loci on FcγR protein expression and function. These studies are expected to aid in generation of a precision medicine strategy to target subjects with or at-risk for T1D who may benefit from immunotherapies with FcγR-associated mechanisms of action.

PI_NAMEs: SHAPIRO, MELANIE R (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Address;Affect;Affinity;Aftercare;alefacept;Antibodies;Antibody Therapy;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Area Under Curve;Autoimmune Diseases;autoimmune pathogenesis;B-Lymphocytes;Biological Assay;Blood specimen;C-Peptide;CD3 Antigens;CD58 gene;cell type;Cells;Chimeric Proteins;Clinical;clinical efficacy;Code;cohort;Copy Number Polymorphism;cross reactivity;CTLA4 gene;Data;Diagnosis;Dose;FCGR2B gene;FCGR3A gene;Flow Cytometry;Generations;genetic association;genetic effector;genetic variant;Genotype;Germ Lines;Globulins;Goals;Hematologic Neoplasms;Human;IgG Receptors;IgG1;Immune;immune modulating agents;Immune Tolerance;Immunoglobulin G;Immunotherapeutic agent;Immunotherapy;immunotherapy trials;improved;Individual;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Intervention Trial;Knowledge;Label;Lymphoma;Malignant Neoplasms;Measures;Mediating;Metabolic;Micro Array Data;monocyte;MS4A1 gene;Natural Killer Cells;Natural Selections;Oryctolagus cuniculus;Participant;Patients;Phagocytosis Induction;Pharmaceutical Preparations;Pharmacodynamics;Pharmacogenomics;precision medicine;preservation;Production;protein expression;protein function;Proteins;Quantitative Trait Loci;receptor;receptor binding;receptor expression;receptor function;Regulation;Remission Induction;response;Rheumatoid Arthritis;Risk;rituximab;Signal Transduction;Single Nucleotide Polymorphism;Structure of beta Cell of islet;success;T-Lymphocyte;Targeted Fusion Protein Therapy;Testing;Therapeutic;Therapeutic antibodies;thymocyte;Transplantation;treatment effect;Treatment Efficacy;treatment group;United States National Institutes of Health;Validation;Variant;Whole Blood

PROJECT_TITLE: Fcy Receptor-Mediated Pharmacogenomics of Antibody Therapies in Type 1 Diabetes

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Biomedical Imaging;Chronic Pain;Clinical Research;Neurodegenerative;Neurosciences;Osteoarthritis;Pain Research;Peripheral Neuropathy

PHR: Project Narrative: The discordance between pain presentation and structural damage in knee osteoarthritis is a crucial issue that hampers both effective clinical management and the development of disease-modifying therapies. This is in part related to different pain phenotypes (nociceptive, nociplastic and neuropathic-like) underlying the chronic pain experience. This proposal investigates the relationship between pain phenotypes and structural damage in knee osteoarthritis.

PI_NAMEs: JARRAYA, MOHAMED  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Address;Adult;Affect;Biological Markers;Biometry;Bone Marrow;career development;Categories;Characteristics;Chronic;chronic pain;clinical development;clinical investigation;Clinical Management;Clinical Research;Clinical Trials Design;cohort;Data;Degenerative polyarthritis;design;Development;Discipline;Disease;effusion;Environment;Epidemiology;Etiology;Evaluation;experience;Funding;Funding Opportunities;General Hospitals;Goals;Grant;Grouping;Health Care Costs;Image;imaging biomarker;improved;Individual;interdisciplinary approach;International;Joints;Knee;Knee Osteoarthritis;knee pain;knee replacement arthroplasty;Knowledge;Lead;Lesion;Magnetic Resonance Imaging;Massachusetts;Measures;Medical;medical schools;Meniscus structure of joint;mineralization;Musculoskeletal;Nervous System;neuroinflammation;Neuropathy;Neurosciences;Nociception;novel therapeutics;Observational Study;osteoarthritis pain;Outcome;Pain;Pain Assessment Tool;Pain Measurement;Pain Nature;Pain Research;pain symptom;Participant;Pathology;Patient Outcomes Assessments;patient subsets;Patients;Persistent pain;Persons;Phenotype;phenotypic biomarker;Prospective Studies;Psychology;Public Health Schools;radiological imaging;radiologist;Radiology Specialty;Research;Research Personnel;response;Rheumatology;Sensory;Series;Severities;skills;Source;structural determinants;Subgroup;success;Symptoms;Synovitis;targeted treatment;Testing;Time;Training;treatment strategy;Work

PROJECT_TITLE: Unraveling the discordance between structural damage and pain phenotypes in knee osteoarthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Maintaining clarity of vision is one of the most important tasks performed by the visual system. This is achieved through the oculomotor process of accommodation. The proposed research will evaluate how accommodation is influenced by properties of natural images such as variation in the spectra of light entering the eye, as well as variation in the spatial properties of the imagery.

PI_NAMEs: CHIN, BENJAMIN MING (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Augmented Reality;Automobile Driving;Award;Behavior;Clinic;Clinical;Color;Complex;Cues;Data;Diagnosis;Ensure;Environment;experience;experimental study;Eye;Goals;Human;human model;Image;Imagery;improved;insight;Joints;Knowledge;Laboratories;lens;Life;Light;Mathematics;Measurement;Measures;Mentors;model building;Modeling;Myopia;oculomotor;ophthalmic examination;Optics;Outcome;Pathway interactions;Patients;Persons;Phase;predicting response;predictive modeling;Procedures;Process;Property;Refractive Errors;Research;response;Retina;retinal imaging;Statistical Models;statistics;Stimulus;Technology;Theoretical model;theories;Translating;Variant;Visible Radiation;Vision;Vision research;Visual;Visual Accommodation;Visual Acuity;visual information;visual stimulus;Visual System;Work

PROJECT_TITLE: Accommodation to polychromatic stimuli

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (03)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Depression;Genetics;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The offspring of parents with major depression have a very high risk of developing mood disorders and other psychopathology themselves. The neurobiological and genetic mechanisms that lead to their vulnerability or resilience remain unclear. Leveraging a unique translational approach with hypotheses generated from rodent studies applied to highly characterized clinical studies and then extended to large diverse population samples, this proposal will investigate hippocampal, genetic and childhood environmental factors that predict onset of depression in children at high risk for mood disorders.

PI_NAMEs: VAN DIJK, MILENNA TAMARA (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adolescent;adverse childhood events;Adverse event;Affect;Age;Award;Biological;blood oxygenation level dependent response;Brain;Brain region;Child;Childhood;Classification;Clinical;Clinical Data;clinical phenotype;Clinical Research;Cognitive;cognitive development;cohort;Collection;Data;Data Set;demographics;dentate gyrus;depressive behavior;depressive symptoms;Development;Diagnosis;Dimensions;disability;Disease;Distress;DNA;Ensure;Environment;Environmental Risk Factor;Event;examination questions;Exercise;experience;Family;Family Study;Frequencies;Functional Magnetic Resonance Imaging;Future;Gene Expression;Gene Expression Profile;Generations;Genetic;Genetic Polymorphism;Genetic Risk;genome wide association study;Goals;high risk;high risk population;Hippocampus;Human;Hyperactivity;Impairment;Individual;Individual Differences;intergenerational;Intervention;Knowledge;large datasets;Link;Longitudinal Studies;Magnetic Resonance Imaging;Major Depressive Disorder;Measures;Mediating;Mental Depression;Mentors;Mentorship;Methods;Modeling;Molecular;Mood Disorders;mortality;mouse model;Mus;neural;Neurobiology;neurogenesis;neuroimaging;Neurons;Neurophysiology - biologic function;New York;novel;offspring;Outcome;Parents;Phase;polygenic risk score;Population;population based;Population Heterogeneity;Predictive Factor;Predisposition;Preparation;Psychopathology;Recording of previous events;Research;resilience;response;Rest;Risk;Risk Estimate;Risk Factors;risk prediction;Rodent;Rodent Model;Sampling;sex;skills;Stimulus;Structure;Symptoms;Testing;theories;Training;Translating;translational approach;transmission process;Universities;Variant;Work;Youth

PROJECT_TITLE: Hippocampal and Genetic Mechanisms Underlying Development of Depression in Children at High Family Risk


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: AMHERST

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative The proposed project addresses unique points related to reproducible development of human iPSC-derived salivary gland organoids, with secretory function and controlled symmetry breaking, via optimization of the physicochemical properties of viscoelastic hydrogels to control progenitor colony differentiation and morphogenesis.

PI_NAMEs: MOHAMED, MOHAMED ALAA ELDEIN (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Acinar Cell;Address;Adhesives;Affect;allyl sulfide;American;Architecture;Autoimmune Diseases;Biochemical;Biological;Biophysics;Cell Communication;cell type;Cells;Characteristics;Complex;Cues;Deglutition;Dependence;Derivation procedure;design;Development;Disease;disease model;Distal;drug discovery;Ductal Epithelial Cell;Ectodermal Dysplasia;Embryo;Embryonic Development;Encapsulated;Engineering;epithelial stem cell;Epithelium;Event;exposed human population;Extracellular Matrix;Feedback;Functional disorder;Generations;Genetic Diseases;Germ Layers;Gland;gland development;Goals;Growth;Head and Neck Cancer;Human;human induced pluripotent stem cells;Hyaluronic Acid;Hydrogels;immunogenic;In Vitro;in vitro Model;induced pluripotent stem cell;Infection;innovation;irradiation;Mastication;matrigel;mechanical properties;Mechanics;microbial;Modeling;Morphogenesis;morphogens;mouse model;Organoids;Outcome;Patients;Peptides;Pluripotent Stem Cells;Polyethylene Glycols;pre-clinical;prevent;Process;progenitor;Property;Protocols documentation;regenerative therapy;Relaxation;Reproducibility;response;restoration;Risk;saliva secretion;Salivary Glands;self assembly;self organization;Site;Sjogren's Syndrome;spatiotemporal;Specific qualifier value;Standardization;stem cell differentiation;stem cell fate;stem cells;Stress;Submandibular gland;Time;Tissues;translational applications;Transplantation;tumorigenic;United States;viscoelasticity;Xerostomia

PROJECT_TITLE: Engineered Viscoelastic Hydrogels for Optimized Generation and Transplantation of Human iPSC-Derived Salivary Gland Organoids to Treat Hyposalivation

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 JC (11)]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Congenital heart disease is the most common type of birth defect, the leading cause of infant death in the United States and often requires surgery. This study will create guidelines on the best way to perform surgeries with computer simulations. When these guidelines are applied in the operating room, patients will have better surgical outcomes and thus live better, longer, healthier lives.

PI_NAMEs: KAISER, ALEXANDER D (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: 3-Dimensional;Affect;Aorta;aortic valve;aortic valve disorder;Area;Bicuspid;bioprinting;Birth;Blood flow;Blood Pressure;Cardiac;Cardiac Surgery procedures;Cardiovascular system;career development;Categories;Child;Child Health;Childhood;Clinic;Clinical;Clinical Research;clinical translation;Clinical Trials;collaborative environment;Computer Models;Computer Simulation;Computing Methodologies;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;Data;Defect;design;Development Plans;Diameter;Differential Equation;Disease;Engineering;engineering design;Environment;experience;Family suidae;flexibility;Functional disorder;Geometry;Growth;Guidelines;Heart failure;Heart Valves;Height;Human;Image;imaging study;improved;improved outcome;In Vitro;in vitro testing;Infant Mortality;innovation;Judgment;Knowledge;Lead;Length;Liquid substance;Magnetic Resonance Imaging;mathematical methods;Mathematics;Measures;Medical;Medical Imaging;Mentors;Methods;Modeling;models and simulation;Motion;multimodality;novel;Operating Rooms;Operative Surgical Procedures;Outcome;patient population;Patients;Pediatric cardiology;Performance;Physiologic pulse;Postoperative Period;Procedures;Prosthesis;prototype;randomized, clinical trials;repaired;Research;Research Personnel;Resources;Risk;simulation;skills;Stenosis;Structure;success;Surgeon;surgery outcome;Techniques;Tissues;tool;Training;Translating;United States;Universities;Validation;valve replacement;Work

PROJECT_TITLE: Optimizing Congenital Aortic Valve Surgery with Simulation-Guided Design

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (MA)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative  During development, each olfactory sensory neuron needs to choose a single odorant receptor (Or) out of a large family of similar genes, and previous research in mice (which have >1,000 Ors) and flies (which have 60 Ors) produced an idea that large Or families employ stochastic gene choice, while small Or families follow deterministic specification. The jumping ant Harpegnathos saltator lies in between these extremes, possessing 376 Or genes, most of which are not interspersed throughout the genome, but located within tandem genomic arrays that contain up to tens of genes. In this proposal, I will test a model where each olfactory neuron in ants expresses a single locus, either a single gene or an array, using the same deterministic mechanism as Drosophila, followed by a novel mechanism of stochastic promoter choice within the arrays.

PI_NAMEs: SIERIEBRIENNIKOV, BOGDAN  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Alleles;Anti-sense RNA;Antibodies;Ants;Architecture;ATAC-seq;Binding Sites;Biological;Biological Assay;Brain;candidate validation;Cells;Chromatin;Chromosomes;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Code;conflict resolution;CRISPR interference;Data;derepression;Development;DNA;DNA Polymerase II;Drosophila genus;Drosophila melanogaster;Enhancers;experimental study;Family;Feedback;fly;Gene Cluster;gene correction;Gene Family;gene repression;Genes;Genetic Transcription;Genome;genomic locus;Genomics;In Situ Hybridization;Individual;Location;Mammals;Modeling;mouse genome;Multiomic Data;multiple omics;Mus;Neurons;novel;Nucleic Acid Regulatory Sequences;Odorant Receptors;Olfactory Pathways;olfactory receptor;olfactory sensory neurons;Open Reading Frames;Pattern;Polymerase;prevent;Production;promoter;protein expression;Proteins;receptor expression;Receptor Gene;Research;RNA;Role;Sensory Receptors;single nucleus RNA-sequencing;Site;Smell Perception;Specific qualifier value;Technology;Testing;Time;Transcript;transcription factor;Transgenic Organisms;Translating;Translations

PROJECT_TITLE: Bridging stochastic and deterministic paradigm of olfactory receptor choice in ants

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: Washington

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: AMERICAN UNIVERSITY

PHR: PROJECT NARRATIVE Dr. Petruzzi is a clinical social worker and health equity researcher who focuses on healthcare access disparities and social work intervention efficacy. The overall purpose of this Career Development Award is to provide Dr. Petruzzi with the training, career development, and mentorship necessary to become an independent, intervention researcher that develops, measures, and implements culturally adapted interventions that simultaneously address the mental health and social needs of underserved Latina women. The specific aims of this proposal are to 1) conduct a community assessment to identify the mental health and social needs of Latina women and inform the development of a culturally adapted intervention; 2) to combine and culturally adapt two, evidence based interventions (problem-solving therapy and patient navigation) for Latinas to improve perinatal mental health; and 3) conduct a feasibility study to assess the acceptability and feasibility of the culturally adapted intervention.

PI_NAMEs: PETRUZZI, LIANA J (contact)

PROGRAM_OFFICER_NAME: GOGINENI, ARUNDHATI

PROJECT_TERMS: acceptability and feasibility;access disparities;Address;antepartum depression;Anxiety;career;career development;Caring;Childbirth;Clinical;clinical trial implementation;Clinical Trials;Clinical Trials Design;Collaborations;Communities;community advisory board;community based participatory research;community engagement;Community Health Aides;Community Healthcare;community intervention;community partners;Community Surveys;Coping Skills;culturally appropriate intervention;Data;Depression screen;design;Development;Disparity;Educational workshop;effectiveness/implementation design;effectiveness/implementation hybrid;ethnic minority;ethnic minority population;Ethnic Minority Women;Evidence based intervention;experience;Feasibility Studies;Federally Qualified Health Center;Feedback;Feeling suicidal;Focus Groups;food insecurity;Future;Goals;Health;Health behavior;health care availability;health care settings;health equity;health literacy;Healthcare Systems;high risk;hospital care;implementation science;improved;Individual;innovation;Insurance Coverage;Intervention;K-Series Research Career Programs;Latina;Latina Population;Latinx;Linguistics;Manuscripts;Maternal Health;maternal morbidity;Maternal Mortality;Measures;medical schools;meetings;Mental Depression;Mental Health;Mental Health Services;Mentors;Mentorship;Morbidity - disease rate;mortality;National Institute on Minority Health and Health Disparities;Nature;novel;obstetric care;Outcome;patient navigation;Patients;Perinatal;perinatal health;perinatal mental health;perinatal period;peripartum depression;population health;Post-Traumatic Stress Disorders;Postdoctoral Fellow;Postpartum Depression;Postpartum Period;Postpartum Women;Pregnancy;pregnant;Pregnant Women;prenatal;primary outcome;problem solving therapy;programs;Provider;Public Health;racial minority;racial minority population;racial minority women;Randomized, Controlled Trials;recruit;Reduce health disparities;Research;Research Design;Research Personnel;Risk Factors;risk mitigation;secondary outcome;Services;skill acquisition;social;Social support;Social Work;Social Workers;Spanish;Standardization;Stress;suicidal;symposium;Symptoms;Texas;Therapeutic Intervention;therapy development;Third Pregnancy Trimester;Time;Training;Transportation;treatment as usual;Treatment Efficacy;Trust;United States;Violence;White Women;Woman;Writing

PROJECT_TITLE: Improving Perinatal Mental Health among Latinas through a Culturally Adapted, Multi-Level Intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (M2)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE The United States has one of the highest incarceration rates and releases over 7 million individuals from jails and prisons annually. This project aims to develop a robust methodology for identifying incarcerated individuals within large healthcare databases, enabling a comprehensive examination of their surgical care. Despite their constitutional right to healthcare, minimal data on the disparities in the surgical care of incarcerated individuals is available, and ultimately, this endeavor holds the potential to catalyze broader healthcare improvements, reducing illness and disability within this marginalized community.

PI_NAMEs: CUPERTINO, ANA PAULA;FLEMING, FERGAL J (contact);LORIA, ANTHONY PATRICK

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Academia;access disparities;Acute;Address;Admission activity;black men;Caring;Cessation of life;Chronic Disease;Code;Collaborations;combat;Communicable Diseases;Communities;Complex;Computerized Medical Record;Constitution;County;court;Data;Data Sources;Databases;disability;Disparity;Ensure;Equity;ethnic minority;Ethnic Origin;experience;Foundations;Future;Health;health care delivery;health care disparity;Healthcare;Hernia;high risk;Hispanic;HIV;Hospitals;Imprisonment;improved;Individual;innovation;inpatient surgery;insight;International Classification of Diseases;Intervention;Jail;Knowledge;Law Enforcement;Legal;Link;male;marginalized community;Medical;Mental disorders;Methodology;Methods;minimally invasive;Minority;Modeling;Morbidity - disease rate;mortality;mortality disparity;multidisciplinary;neighborhood disadvantage;New York;Operative Surgical Procedures;Outcome;Patients;Policies;Policy Analysis;Population;Predictive Value;Prisons;Process;Public Health;Race;racial minority;Research;Research Personnel;Resources;Sample Size;Severity of illness;socioeconomics;Source;Source Code;Specificity;statistics;Substance Use Disorder;Supervision;surgery outcome;Surgical complication;surgical research;System;systematic review;underserved community;United States;United States Agency for Healthcare Research and Quality;Universities;Validation;Viral hepatitis;Work

PROJECT_TITLE: Unlocking Equity: Validating Methodologies & Evaluating Surgical Care for Incarcerated Individuals

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: TULSA

ORG_NAME: LAUREATE INSTITUTE FOR BRAIN RESEARCH

ORG_STATE: OK

PHR: Narrative Inflammation is thought to play a role in the pathogenesis of major depressive disorder (MDD), but the exact immunoregulatory mechanisms are not well understood. This proposal will leverage an ongoing experimental medicine study using lipopolysaccharide to compare immune mechanisms and regulation of the toll-like receptor 4 inflammatory pathway in MDD and healthy participants in both the blood and the brain. The results may provide a roadmap for understanding how the immune system is dysregulated in MDD and for the identification of novel therapeutic targets.

PI_NAMEs: FIGUEROA-HALL, LEANDRA KALI (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Acids;Acute;Agonist;Astrocytes;Behavioral;Blood;blood-brain barrier crossing;Brain;C-reactive protein;Chronic stress;Clinical assessments;Clinical Data;Clinical Research;cytokine;Data;Depressed mood;depressive symptoms;Detection;detection platform;Disease;Double-Blind Method;Endotoxemia;evidence base;Exposure to;extracellular vesicles;Flow Cytometry;Hour;IL8 gene;Immune;Immune response;Immune signaling;Immune system;Immunoassay;Immunologics;immunoregulation;Impairment;in vivo;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Infusion procedures;Interleukin-6;Investigation;Leaky Gut;Ligands;Lipopolysaccharides;lymphotoxin beta;Major Depressive Disorder;Mediating;Medicine;Mental Depression;microbial;Microglia;Molecular;Moods;mRNA Transcript Degradation;new therapeutic target;next generation sequencing;novel;Participant;pathogen;Pathogen detection;Pathogenesis;Pathway interactions;Pattern;Peripheral;Phase;Physiological;placebo controlled study;Placebos;Plasma;Play;preclinical study;primary outcome;Production;Proteins;Psychiatry;Randomized;Recording of previous events;Regulation;Research Personnel;response;Risk;RNA;Role;safety assessment;Saline;Sampling;Serum;Severities;Signal Transduction;Stress;Techniques;Time;TLR4 gene;TNF gene;Training;transcriptome sequencing;Visit

PROJECT_TITLE: In vivo inflammatory challenge to elucidate the role of the toll-like receptor 4 pathway in depression


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Genetics;Infectious Diseases;Inflammatory Bowel Disease;Microbiome;Precision Medicine

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  Innate lymphoid cells reside on the mucosal surface and orchestrate tissue homeostasis; however, their regulatory mechanisms and clinical significance in intestinal inflammation remain unclear. Here, we intend to unravel the mechanistic role of IRE1α-XBP1-mediated endoplasmic reticulum stress in innate lymphoid cells and their implications in inflammatory bowel disease, using a comprehensive approach involving multicellular organoid culture, mouse models, and human samples. After completion of these studies, I anticipate I will be well-prepared to establish an independent research program and be highly competitive for R-series grants.

PI_NAMEs: CAO, SIYAN  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Acute;Advisory Committees;Antibodies;Antigen Presentation;Autoimmune;Bacterial Infections;Biological Assay;Biological Markers;Career Choice;career development;Cell Communication;Cells;Cellular Stress;Cessation of life;chromatin immunoprecipitation;Chronic;Clinical Research;clinically significant;Coculture Techniques;cohort;Colitis;Committee Members;Communities;Crohn's disease;cytokine;Cytokine Gene;Data;Development Plans;Disease Management;disease model;Doctor of Medicine;Doctor of Philosophy;endoplasmic reticulum stress;Ensure;enteric infection;Epithelial Cells;Exhibits;experience;experimental study;Fellowship;Fibrosis;Frequencies;Funding;Gastroenterology;Gene Expression;Genetic;Genetic Transcription;genome wide association study;Goals;Grant;gut inflammation;gut microbiome;helminth infection;Homeostasis;Human;human data;Immune;Immunology;Inflammation;Inflammatory;Inflammatory Bowel Diseases;instructor;Interleukin-12;interleukin-23;intestinal epithelium;Intestinal Fibrosis;intestinal homeostasis;Intestines;Knowledge;Knowledge acquisition;Laboratories;Link;Lymphocyte;Lymphoid Cell;Mediating;medical schools;Medicine;Mentors;Mentorship;Messenger RNA;Metagenomics;microbial;microbiome;Mitochondria;Modeling;Modification;mouse model;mRNA Decay;Mucous Membrane;murine colitis;Mus;Natural Immunity;novel;Organoids;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peripheral;personalized management;Physiological;Positioning Attribute;precision medicine;predicting response;Production;Program Development;programs;Proliferating;Proteins;Reactive Oxygen Species;Research;Research Personnel;response;response biomarker;RNA;Role;Sampling;Series;skills;Stimulus;Stress;success;Surface;T-Lymphocyte;targeted treatment;Technical Expertise;Therapeutic Intervention;Tissues;transcriptomics;treatment response;Universities;Washington;Work;XBP1 gene

PROJECT_TITLE: Endoplasmic Reticulum Stress Controls Innate Lymphoid Cells in Intestinal Inflammation

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Substance Misuse

PHR: Narrative. While alcohol misuse remains a leading cause of preventable death and disability, non-alcoholic beverages that seek to mimic alcohol (e.g., non-alcoholic beers, non-alcoholic wines, non-alcoholic liquor, and “mocktails”) are drastically increasing in popularity, especially among people who consume alcohol. This project will examine whether non-alcoholic beverage consumption helps to reduce alcohol use or paradoxically stimulate it. Clarifying the potential utility of non-alcoholic beverages and whether their effects differ based on alcohol use history will ultimately inform clinical recommendations for people with alcohol use disorder and public health messaging at large.

PI_NAMEs: BOWDRING, MOLLY  (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: addiction;Address;Adult;Age;alcohol abuse therapy;alcohol behavior;Alcohol consumption;alcohol craving;alcohol cue;alcohol misuse;alcohol research;alcohol use disorder;Alcohols;approach behavior;Area;Award;Beer;Behavior;Behavioral;Beverages;Blood alcohol level measurement;career;Cellular Phone;Clinical;clinical practice;Clinical Practice Guideline;Clinical Research;Consumption;craving;Cues;Data;Dedications;Diagnosis;Diagnostic;disability;distilled alcoholic beverage;drinking;Ecological momentary assessment;experience;Goals;Habits;Health Policy;Health Professional;incentive salience;Individual;Individual Differences;insight;Intervention;Interview;Knowledge;Licensing;Marketing;Measures;Mentors;Mentorship;Methodology;Methods;Modeling;National Institute on Alcohol Abuse and Alcoholism;non-alcoholic;novel;Participant;Pattern;Persons;Phase;portability;prevent;preventable death;Prevention strategy;Provider;Psychologist;psychosocial outcome;Public Health;Recommendation;Recording of previous events;recruit;reduced alcohol use;reinforcer;Reporting;Research;Research Personnel;response;Role;Sales;Sample Size;social;Study models;Subgroup;Surveys;Testing;theories;Time;Training;translational research program;Wine

PROJECT_TITLE: Non-alcoholic beverages: A foundational assessment of their potential utility in reducing alcohol use

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2 (AA)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE  Cardiovascular (CV) toxicities from common cancer therapies (trastuzumab, anthracyclines, or left chest radiation) can lead to cardiovascular disease (heart failure, myocardial infarction, and stroke) and are more common among marginalized racial and ethnic groups, and those with adverse social determinants of health (SDOH) such as lower levels of socioeconomic status and living in disadvantaged neighborhoods or rural areas. Yet, the role of complex SDOH in CV toxicity disparities among breast cancer survivors is unknown, and few studies have considered the intersections among race, ethnicity, and other SDOH. This K01 aims to: 1) identify the extent of disparities in incident CV toxicity among breast cancer survivors in Arkansas based on race, ethnicity, neighborhood socioeconomic status, and geography; and 2) develop a predictive algorithm for risk stratification in breast cancer survivors at high risk for CV toxicity using machine-learning approaches that incorporate race, ethnicity, and SDOH to move beyond describing disparities in CV toxicities to informing targeted interventions to improve the CV health of breast cancer survivors.

PI_NAMEs: PARK, YONG-MOON MARK (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Address;advanced analytics;Age;analytical method;Anthracycline;Arkansas;Bayesian Modeling;Black race;breast cancer diagnosis;Breast Cancer survivor;Breast Cancer survivorship;cancer epidemiology;Cancer Survivor;Cancer Survivorship;cancer therapy;Cardiac;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Chest;Clinical;clinical data repository;Clinical Decision Support Systems;Clinical Medicine;comorbidity;Competence;Complex;Data;Data Analyses;Databases;Development;Diagnosis;Dimensions;Disparity;Dyslipidemias;electronic health information;Electronic Health Record;electronic health record system;Ethnic Origin;Ethnic Population;experience;Female Breast Carcinoma;follow-up;Functional disorder;General Population;Geography;Goals;Grant;Health Disparities Research;health disparity;Healthcare;Heart failure;high risk;Hypertension;improved;Individual;Insurance Coverage;intersectionality;Intervention;intervention program;K-Series Research Career Programs;Left;Link;longitudinal analysis;Machine Learning;machine learning method;machine learning prediction;Malignant Breast Neoplasm;Malignant Neoplasms;marginalization;Mediating;Mediation;Medical;Modeling;Morbidity - disease rate;mortality;Myocardial Infarction;National Heart, Lung, and Blood Institute;neighborhood disadvantage;Neighborhoods;neoplasm registry;Non-Insulin-Dependent Diabetes Mellitus;Oncology;population health;prediction algorithm;Prevention program;Preventive Medicine;Public Health;Race;racial population;Radiation;Recurrent tumor;Research;Research Personnel;Risk;risk prediction model;risk stratification;Role;rural area;Science;Services;skills;social epidemiology;social factors;social health determinants;socioeconomic disparity;Socioeconomic Status;socioeconomics;Stroke;tool;Toxic effect;Training;Trastuzumab;Treatment-Related Cancer;Universities;Woman;World Health

PROJECT_TITLE: Understanding disparities in cardiovascular toxicity among breast cancer survivors in Arkansas

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (MA)]


ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative This proposal will provide insight into how the potent sex-steroid hormone 17-estradiol (E2) controls gene expression programs in a cell-type specific manner in the hippocampus, a brain region important for learning and memory whose function is compromised during aging and in certain mental health disorders. The proposed research is relevant to public health because it will improve our understanding of the neurobiological underpinnings that support healthy cognitive function, and inform the development of sex-specific therapeutic intervention strategies to treat neuropsychiatric disorders influenced by the hormonal milieu. Moreover, this work is particularly relevant to the NIMH’s first Strategic Objective (Strategy 1.1) which seeks to define cellular and molecular gene regulatory mechanisms relevant to cognitive function and mental health.

PI_NAMEs: TUSCHER, JENNIFER J (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Adult;Aging;Anabolism;Aromatase;Astrocytes;ATAC-seq;Binding;Biological Assay;Brain;Brain region;Categories;Cell Nucleus;cell type;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;cognitive function;CREB1 gene;CRISPR interference;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;Development;Dimerization;DNA;Dorsal;Electrophysiology (science);Enzymes;Epigenetic Process;ESR1 gene;Estradiol;Estrogen Receptors;estrogenic;Estrogens;experimental study;Female;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;genetic signature;Genetic Transcription;genomic locus;Glutamates;Gonadal Steroid Hormones;Hippocampus;Hormonal;Hour;improved;Individual;insight;Interneurons;Intervention;Learning;life span;long term memory;male;Mediating;Membrane;Memory;Mental disorders;Mental Health;Molecular;Morphology;National Institute of Mental Health;Neurobiology;Neuroendocrinology;neuronal excitability;Neuronal Plasticity;Neurons;neuropsychiatric disorder;neuroregulation;novel;Oligodendroglia;Outcome;Pathway interactions;pharmacologic;Physiology;Play;Population;prevent;Process;Production;programs;Property;Public Health;receptor;Recreation;Regulation;Research;Resolution;response;Response Elements;Rodent;Role;sex;Signal Transduction;single nucleus RNA-sequencing;Testing;Therapeutic Intervention;therapeutic target;tool;transcription factor;Transcriptional Regulation;transcriptomics;Transposase;treatment strategy;Work

PROJECT_TITLE: Estradiol-mediated Gene Signatures in Hippocampal Memory


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Pediatric;Primary Health Care

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: This project will develop new statistical methods for evaluating the causal effects of bundled (multi- component) treatment. The methods will help in understanding the mechanisms by which complex interventions affect dental outcomes, including behaviors such as taking children to the dentist. The methods may also help in formulating new treatments and predicting their effects. The statistical methods will be applied to real data from a recently completed randomized clinical trial of a multi- component intervention to improve dental care usage and dental caries outcomes. This research will thus yield new statistical methods and knowledge that may lead to improved study designs and predictions of new treatment effects, and ultimately, better health care and dental outcomes.

PI_NAMEs: ALBERT, JEFFREY M (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: 6 year old;Affect;Attention;Behavior;Caregivers;causal model;Child;Clinical Trials;Complex;Computerized Medical Record;Cost efficiency;Data;Data Analyses;Dental;Dental Care;Dental caries;Dental Research;Dentists;design;Development;Disadvantaged;Education;electronic medical record system;Enrollment;Future;Healthcare;improved;Individual;interest;Intervention;intervention effect;Knowledge;Measurement;Measures;Mediation;Mediator;Medicaid;method development;Methodology;Methods;Modeling;multi-component intervention;National Institute of Dental and Craniofacial Research;NIH Program Announcements;novel;Oral health;Outcome;Outcome Measure;Patients;Policies;primary care setting;Property;Provider;Randomized;randomized, clinical trials;Research;Research Design;Research Personnel;Research Project Grants;response;simulation;standard care;Statistical Methods;Time;treatment adherence;treatment effect;two-arm trial;user-friendly;Variant;Well Child Visits

PROJECT_TITLE: Modeling Causal Effects of Components of Bundled Interventions with Application to a Multilevel Dental Caries Clinical Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 CC (13)]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Prevention;Sepsis

PHR: Narrative Severe trauma followed by hemorrhagic shock (T/HS) through cell priming mechanisms predisposes patients to infection with sepsis being a prominent contributor to late death in these patients. Few specific targets linking T/HS to elevated risk of sepsis have been identified since the mechanisms of T/HS-primed infection remain unclear. This proposal is to investigate a novel mechanism underlying T/HS-predisposed sepsis, in which T/HS-induced arachidonic acid (AA) metabolite-lipoxygenase feedback loop causes macrophage death and dysfunction, and therefore, subsequent augmented infection and organ injury. Furthermore, this study will test new therapeutic potential to improve the outcomes of post-T/HS infection.

PI_NAMEs: FAN, JIE  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Address;Affect;ALOX15 gene;Antiinflammatory Effect;Arachidonic Acids;Automobile Driving;Bacteria;Cells;Cessation of life;Clinic;Clinical;enzyme feedback;Enzymes;Face;Fatty Acids;Feedback;Functional disorder;Gene Modified;Generations;Genetic;GPR31 receptor;Hemorrhagic Shock;Heterogeneity;Hospitalization;Hydroxyeicosatetraenoic Acids;improved;improved outcome;In Vitro;in vivo;Infection;Inflammation;inhibitor;knockout gene;Knockout Mice;Link;Lipoxygenase;Lung;Macrophage;Mediating;Messenger RNA;Modeling;mortality;mouse model;new therapeutic target;novel;novel therapeutics;organ injury;Pathway interactions;Patients;Phagocytosis;Plasma;post-trauma;predictive marker;Predisposition;Prevention;Prevention strategy;Regulation;response;Risk;Role;secondary infection;Secondary to;Sepsis;single cell proteins;Survival Rate;Survivors;Testing;Therapeutic;Time;Transcriptional Regulation;Trauma;Trauma patient;Up-Regulation

PROJECT_TITLE: Mechanism of Trauma/Hemorrhagic Shock-Predisposed Sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-D (02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Mental Health;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PUBLIC HEALTH RELEVANCE High blood pressure is estimated to cost the United States 131 to 198 billion dollars annually. High blood pressure is one of the most influential risk factors for cardiovascular disease, which is a leading cause of death in the United States. Despite increased knowledge, awareness and uptake in hypertensive medications, racial/ethnic disparities in hypertension persist. Physical activity (PA) is a key, modifiable lifestyle modification that can improve BP outcomes and reduce hypertension risk. Yet, uptake of PA remains low among Black women. We propose to test the proof-of-concept of a technology-delivered mindful walking intervention among Black women with hypertension to increase PA and reduce BP.

PI_NAMEs: KALINOWSKI, JOLAADE  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Address;Adult;Affect;arm;Asian Women;Awareness;Black race;black women;Blood Pressure;blood pressure reduction;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Caring;Cause of Death;Child Care;Connecticut;cost;Death Rate;Dedications;design;Development;Diabetes Mellitus;Diastolic blood pressure;Disease;Disparity;efficacy trial;Emotions;Enrollment;Environment;Equipment;ethnic disparity;exercise adherence;exercise intervention;Facebook;Facebook delivery;Feasibility Studies;feasibility testing;Feedback;Focus Groups;Future;Goals;Guidelines;Health;Health behavior;Hispanic Women;Home;Hypertension;hypertensive;improved;Incidence;Individual;Influentials;Informal Social Control;insight;Intervention;intervention delivery;intervention refinement;Investments;Knowledge;Life Style Modification;Link;Mentors;mind/body;mindfulness;Modality;Modeling;moderate-to-vigorous physical activity;modifiable risk;Outcome;Participant;perceived stress;Pharmaceutical Preparations;Physical activity;Population;post intervention;Preparation;Prevalence;Privatization;public health relevance;racial disparity;Recommendation;recruit;remote delivery;Research;Research Personnel;Risk;Risk Factors;Role;rumination;Safety;Schedule;Self Care;self-compassion;skills;social expectations;social media;Social support;Stress;stress management;stress reduction;Technology;Testing;therapy design;therapy development;Training;Transportation;treadmill;United States;Universities;uptake;Walking;walking intervention;White Women;Woman;Work

PROJECT_TITLE: Proof of Concept Trial of a Mindful Walking Intervention for Black Women with Hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-A (M1)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Neurodegenerative;Neurosciences;Rehabilitation;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

PHR: PROJECT NARRATIVE:  One of the devastating, yet understudied outcomes of stroke is a persistent deterioration of cognitive abilities in stroke survivors. Previous studies and my preliminary data suggest that transcranial direct current stimulation (tDCS) indicate that this non-invasive brain stimulation methodology may provide an important therapeutic approach to combat post-stroke cognitive impairment. Further, my research proposal will explore understudied mechanisms by which tDCS exerts its effect on cognitive function in stroke survivors.

PI_NAMEs: PINTO, CAMILA  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: acute stroke;Age;Animals;Anodes;Award;Back;Blood flow;Blood Vessels;Brain;brain cell;brain electrical activity;brain tissue;Case Series;Cause of Death;cerebral hemodynamics;Cerebrovascular Circulation;Cerebrum;Chronic;Clinical;Cognition;Cognitive;cognitive ability;cognitive function;cognitive performance;cognitive process;cognitive testing;combat;Controlled Clinical Trials;cost effective intervention;Data;Data Correlations;Dementia;Deterioration;Diagnosis;effective therapy;Electroencephalography;Endothelium;Enrollment;executive function;experience;flexibility;functional near infrared spectroscopy;functional outcomes;Health Care Costs;Healthcare Systems;hemodynamics;High Prevalence;hypoperfusion;Impaired cognition;Impairment;improved;Individual;innovation;interest;Intervention;Ischemic Stroke;Lesion;Long term disability;Measures;Mediating;Mentors;Metabolic;Methodology;Microvascular Dysfunction;mild cognitive impairment;multimodality;Neurons;Neurosciences Research;neurovascular;neurovascular coupling;noninvasive brain stimulation;novel;Participant;Patients;Phase;Pilot Projects;placebo group;post stroke;post stroke cognitive impairment;Prefrontal Cortex;prospective;Public Health;Quality of life;Randomized;Reporting;Research;Research Personnel;Research Proposals;response;Rest;Role;Scalp structure;sex;Short-Term Memory;skills;Stroke;stroke event;stroke outcome;stroke recovery;stroke survivor;stroke therapy;survival outcome;Techniques;Testing;Therapeutic;Therapeutic Intervention;transcranial direct current stimulation;United States;United States National Institutes of Health;Vascular Cognitive Impairment;Work

PROJECT_TITLE: Non-invasive brain stimulation and neurovascular mechanisms of post-stroke cognitive impairment

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Serious Mental Illness

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE This research aims to develop a novel personalized transcranial magnetic stimulation approach tailored explicitly to depressive disorders. The proposed work will involve neuroengineering developments of a closed-loop stimulation system, experimental research in humans, and a feasibility trial. These efforts will improve our understanding of the brain mechanisms and therapeutic options in depression.

PI_NAMEs: ALEKSEICHUK, IVAN  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Action Potentials;Adult;Affect;Aftercare;Anatomy;approach/avoidance behavior;Area;Behavior;Behavioral;Biological Markers;Brain;career;Chemosensitization;Chronic;Clinical;Clinical Trials;Cognition;cognitive testing;Compensation;Coupled;Coupling;Cross-Over Studies;depressive behavior;Depressive disorder;depressive symptoms;Development;disability;Double-Blind Method;Drug resistance;electric field;Electroencephalography;Electrophysiology (science);Equilibrium;experimental study;FDA approved;Feasibility Studies;feasibility trial;Frequencies;Functional disorder;Future;Goals;Hamilton Rating Scale for Depression;Human;Image;improved;improved outcome;Individual;individual variation;individualized medicine;insight;inter-individual variation;Intervention;Left;Life;Link;magnetic field;Magnetic Resonance Imaging;Major Depressive Disorder;Mental Depression;Mental disorders;Methods;Modernization;Motor;neural;neural circuit;Neuronal Plasticity;Neuronavigation;Neurons;Nicotine Dependence;novel;Obsessive-Compulsive Disorder;Outcome;Patients;Performance;Periodicity;Personal Satisfaction;personalized approach;personalized medicine;Phase;Physiologic pulse;placebo controlled study;Population;precision medicine;precision neuromodulation;Prefrontal Cortex;programs;Protocols documentation;prototype;Randomized;reduce symptoms;repetitive transcranial magnetic stimulation;Research;Research Personnel;Role;skills;Societies;spatial integration;spatiotemporal;Specificity;success;Suicide attempt;Symptoms;System;Technology;Testing;Therapeutic;Time;Transcranial magnetic stimulation;Treatment outcome;United States;Work

PROJECT_TITLE: Personalized Closed-loop Theta Burst Stimulation for Treatment of Depression


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Activated microglia/macrophages play key roles in the pathogenesis of Alzheimer’s disease (AD). The goal of this proposal is to develop a CD206-specific PET probe that can cross the blood-brain barrier to noninvasively detect CD206+ microglia/macrophages and reparative inflammation in AD.

PI_NAMEs: WANG, CUIHUA  (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Affinity;allodynia;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;amphiphilicity;Amyloid;Amyloid deposition;Anti-Inflammatory Agents;attenuation;behavioral outcome;Binding;Biochemical;Biodistribution;blood-brain barrier crossing;Brain;cell injury;Cells;Clinical;cost;Data;Deposition;design;Development;Equilibrium;first-in-human;Flow Cytometry;fluorodeoxyglucose positron emission tomography;Fucose;Future;Glioblastoma;Glioma;Glycoproteins;Goals;hydrophilicity;Hydrophobicity;Image;imaging approach;imaging modality;imaging probe;Infiltration;Inflammation;Inflammatory;Innate Immune Response;Integral Membrane Protein;iron oxide nanoparticle;Label;Length;Lipids;lipophilicity;Macrophage;Magnetic Resonance Imaging;Mannose;mannose receptor;Maps;Measures;Microglia;Monitor;mouse model;Mus;Nervous System Disorder;Neurofibrillary Tangles;Non-Invasive Detection;non-invasive imaging;novel;novel therapeutics;Output;pathogen;Pathogenesis;Pathologic;Peroxidases;Phagocytes;Phagocytosis;Phenotype;Play;Positron-Emission Tomography;pre-clinical;Process;Property;Proteins;repaired;response;Rodent Model;Role;Serum;Specificity;Surface;tau aggregation;tau Proteins;Testing;Therapeutic;therapeutic biomarker;Therapeutic Effect;therapeutic target;tissue repair;tool;Tracer;Transgenic Organisms;treatment effect;tumor;water maze;Work;Wound models

PROJECT_TITLE: Development of an amphiphilic PET probe to detect CD206+ microglia/macrophages in Alzheimer's disease

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]