NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Alcohol use disorders are common in the U.S. Alcohol (ethanol) directly modulates ion channels that control the excitability of neurons. The goal of this grant is to investigate the structural and functional mechanisms underlying ethanol-dependent activation of potassium channels and develop novel pharmaceutical agents that specifically modulate the effects of ethanol in the brain.

PI_NAMEs: SLESINGER, PAUL A (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Affect;Affinity;Agonist;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol measurement;alcohol seeking behavior;alcohol use disorder;Alcohol withdrawal syndrome;alcohol-related death;Alcoholism;Alcohols;Amygdaloid structure;analog;Anticonvulsants;Behavior;Behavioral;Behavioral Model;Binding;binge drinking;Blood;Brain;Cause of Death;Central Nervous System;Chronic;Complex;conditioned place preference;conditioning;dopaminergic neuron;Ethanol;Ethanol dependence;excitatory neuron;Exhibits;FDA approved;Fiber;Funding;genome wide association study;GIRK1 subunit, G protein-coupled inwardly-rectifying potassium channel;GIRK2 subunit, G protein-coupled inwardly-rectifying potassium channel;glutamatergic signaling;Glutamates;Goals;Grant;GTP-Binding Proteins;Hippocampus;Human;in vivo;Inhalation;Inhalation Exposure;innovation;Intoxication;inward rectifier potassium channel;Ion Channel;Knockout Mice;Legal;Ligands;Measures;Medial;Mediating;Memory;Modeling;Molecular;mouse model;neuronal excitability;Neurons;neurotransmitter release;Neurotransmitters;novel;novel strategies;novel therapeutics;Nucleus Accumbens;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Photometry;Potassium;Potassium Channel;Prefrontal Cortex;prevent;Property;Proteins;Rewards;screening;sensor;small molecule;structural biology;Testing;tool;United States;vapor;Withdrawal;Work

PROJECT_TITLE: Structural Analysis of Alcohol-dependent Activation of GIRKs

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE STATEMENT: The proposed work seeks to advance and broadly deploy MRI methods to visualize regional lung function rapidly, non-invasively and 3-dimensionally. Here we apply these techniques to patients with idiopathic pulmonary fibro- sis where we seek to observe therapy response earlier than is possible with conventional lung function tests.

PI_NAMEs: DRIEHUYS, BASTIAAN  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: 3-Dimensional;Acceleration;Adoption;Alveolar;base;Biological Markers;Biomedical Technology;Blood capillaries;Cessation of life;Chest;Chronic;Chronic Obstructive Pulmonary Disease;Cicatrix;Clinical;clinical care;clinical decision-making;Clinical Research;cohort;cost;COVID-19;Detection;Development;Diagnosis;Diffusion;Disease;Disease Progression;Dose;Erythrocytes;experience;Fibrosis;fibrotic lung disease;Functional impairment;Functional Magnetic Resonance Imaging;functional status;Gases;Goals;Health;Hospitalization;idiopathic pulmonary fibrosis;Image;Impairment;improved;Individual;individual patient;Industry;Inhalation;innovation;interest;interstitial;Intervention Trial;Lung;Lung Diseases;Magnetic Resonance Imaging;Malignant Neoplasms;Measurement;Measures;Methods;Mission;Modality;Monitor;Multicenter Studies;Multicenter Trials;nintedanib;normal aging;novel;novel strategies;novel therapeutics;Outcome;outcome prediction;Pathology;Patient Care;Patients;Pattern;Pharmaceutical Preparations;Phenotype;physiologic model;Physiological;Pirfenidone;Placebos;Positioning Attribute;Prevalence;Prognosis;programs;Property;Protocols documentation;public health relevance;Publishing;pulmonary function;pulmonary function decline;Pulmonary function tests;pulmonary vascular disorder;Reader;reconstruction;Research;side effect;Site;Standardization;structural imaging;Techniques;Technology;Testing;therapeutic biomarker;therapeutic development;Time;Tissues;tool;Transplantation;Treatment Efficacy;treatment response;United States National Institutes of Health;uptake;Vendor;ventilation;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary Fibrosis

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Orphan Drug;Patient Safety;Radiation Oncology;Rare Diseases;Transplantation

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Dry mouth due to radiation therapy is a significant toxicity experienced by many head and neck cancer patients, for which there is no effective treatment. We will perform a clinical trial to test the safety of injecting mesenchymal stromal cells (MSCs) isolated from a patient’s bone marrow into their salivary glands to treat this debilitating condition. It is our long-term objective to develop this innovative approach into a new and effective treatment to improve the lives of our patients suffering from dry mouth caused by radiation therapy.

PI_NAMEs: KIMPLE, RANDALL J. (contact)

PROGRAM_OFFICER_NAME: FISCHER, DENA

PROJECT_TERMS: Acupuncture Therapy;Adipose tissue;Affect;Applications Grants;Autologous;Autologous Transplantation;Bone Marrow;Cancer Center;Candy;Caring;Cell Separation;Cell Therapy;Cells;Characteristics;Chewing Gum;Cholinergic Agonists;Clinical;Clinical Protocols;Clinical Trials;Clinical Trials Design;cohort;Conduct Clinical Trials;Cryopreservation;Data;Deglutition;Dental caries;Dentition;design;Dimensions;Disease;Dose;Dysgeusia;effective therapy;efficacy evaluation;efficacy testing;emotional functioning;Engineering;Enrollment;Ensure;Environment;epithelial stem cell;Esthesia;experience;Fatigue;Fibrosis;first-in-human;Functional disorder;Future;Goals;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;healing;Hyperbaric Oxygen;Impairment;implantation;improved;improved outcome;Infection;Infrastructure;Injections;innovation;Institution;Interferon Type II;Knowledge;Lead;Legal patent;Licensing;Lubricants;lymph nodes;Manuals;Marrow;medical schools;mesenchymal stromal cell;morphogens;Mus;National Institute of Dental and Craniofacial Research;Natural regeneration;non-invasive imaging;nutrition;Nutritional status;Outcome;Outcome Measure;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Phase;phase 2 study;phase I trial;preclinical study;primary endpoint;Primary Neoplasm;Procedures;Production;Public Health;Quality of life;Radiation;Radiation therapy;Recommendation;Recovery;Regenerative capacity;Reporting;research clinical testing;Research Personnel;Resources;response;Role;Safety;safety testing;Saliva;saliva composition;saliva function;Salivary;Salivary Glands;secondary endpoint;side effect;Site;Sleep;Social Functioning;stem cell biology;Stimulant;Structure;study population;Submandibular gland;success;sucking;System;Taste Perception;Technology;Therapeutic;Time;tool;Toxic effect;United States National Institutes of Health;Universities;Water;Wisconsin;Work;Xerostomia

PROJECT_TITLE: Intra-salivary gland autotransplantation of marrow mesenchymal stromal cells for treatment of radiation induced xerostomia


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Genetics;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT (Narrative) Monocytes may contribute to the normal ontogeny of microglia and produce pathological microglia after neonatal brain injury. This project will characterize monocyte-derived microglia in normal development and pathological microglia after neonatal brain injury in murine models. Positive outcomes of the project may shed mechanistic insights and have a translational value for clinical management.

PI_NAMEs: KUAN, CHIA-YI  (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Ablation;Acute;ARHGEF5 gene;Bacterial Artificial Chromosomes;Behavior;behavioral outcome;Biological Availability;Birth;Brain;Brain Hypoxia-Ischemia;Brain Injuries;CCL2 gene;cell type;Cells;Chronic;Clinical;Clinical Management;Clinical Trials;cognitive function;cytokine;Data;Development;developmental disease;Dichloromethylene Diphosphonate;Disease;Disease associated microglia;Dose;Generations;Genes;Growth;Heterogeneity;Heterozygote;Histologic;Histology;hypoxic ischemic injury;Hypoxic-Ischemic Brain Injury;immune cell infiltrate;Impairment;improved;Inflammation;inhibitor;Injections;Injury;insight;Intravenous;Invaded;Label;Lipopolysaccharides;Liposomes;Location;Macrophage;Maps;Mediating;Methods;Microglia;Modeling;monocyte;mouse model;Mus;NADPH Oxidase;Neonatal;Neonatal Brain Injury;neonatal hypoxic-ischemic brain injury;neonatal injury;neonatal period;Nerve Degeneration;neural network;neurodevelopment;neuron loss;neurotoxicity;new therapeutic target;novel;Oral;Outcome;Pathologic;Perinatal Brain Injury;prenatal;progenitor;public health relevance;Role;single-cell RNA sequencing;Source;Stroke;Structure of choroid plexus;Synapses;Tamoxifen;Testing;Therapeutic Effect;Toxin;transcriptome;transcriptome sequencing;Transgenic Mice;TREM2 gene;Yolk Sac

PROJECT_TITLE: Monocyte-Derived Microglia in Development and after Neonatal Brain Injury

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Research has established that compounds aimed at neuropeptide Y (NPY) receptors are protective against dependence-induced alcohol drinking, and our recent findings show that compounds targeting NPY receptors are also protective against excessive binge-like drinking in mice when targeted to regions of the extended amygdala. Expected results in the current application will significantly expand our recent observations by showing the NPY circuits in the medial prefrontal cortex modulate binge-like ethanol drinking by providing top- down modulation of the extended amygdala.

PI_NAMEs: THIELE, TODD ERIC (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Abstinence;Address;Agonist;Alcohol consumption;alcohol exposure;alcohol response;alcohol seeking behavior;alcohol sensitivity;alcohol use disorder;Alcohols;Amygdaloid structure;antagonist;Anxiety;Attention;Behavior;binge drinking;Brain;Cell Nucleus;Consumption;Dangerousness;Dependence;Disease;Down-Regulation;drinking;drug of abuse;early experience;Electrophysiology (science);Ethanol;Female;Fright;Funding;Genetic;Glutamates;Goals;Grant;Health;hippocampal pyramidal neuron;Histologic;immunoreactivity;Infusion procedures;Injections;innovation;insight;Intake;Investigation;Knowledge;Learning;Link;Literature;male;Medial;Mediating;Mus;neural circuit;Neurobiology;neurochemistry;Neuronal Plasticity;Neurons;neuropeptide Y;Neuropeptide Y Receptor;novel;overexpression;Pathway interactions;Pattern;Prefrontal Cortex;Preparation;problem drinker;receptor;receptor expression;Receptor Signaling;Recording of previous events;Relapse;Reporter;Research;Role;Signal Transduction;Site;Slice;Structure of terminal stria nuclei of preoptic region;Testing;tool;Transgenic Organisms;Viral;Virus;Whole-Cell Recordings

PROJECT_TITLE: Neuropeptide Y: Role in Ethanol Intake and Sensitivity


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Machine Learning and Artificial Intelligence

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

ORG_STATE: CA

PHR: PROJECT NARRATIVE Although the field has discovered many hallmarks of aging, the causes and connections between these hallmarks are largely unknown due to the fact that we do not know how each protein changes in a proteome during aging. To fill the gap, we have developed a new high-throughput method and machine learning tools to systematically track the fate of each individual protein, including its expression, localization, aggregation, and timing of these changes (4D fate map), during the replicative aging of budding yeast. Our pilot test of this method revealed novel aging mechanism of mitochondria and the proposed work will advance both the breadth and depth of our molecular understanding of aging by establishing a 4D reference map of aging proteome for the field, which will help determine the new mechanisms and connections between different aging hallmarks (e.g., mitochondrial and vacuole/lysosome dysfunction).

PI_NAMEs: ZHOU, CHUANKAI  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: age related;age related changes;Aging;aging mechanism;Belief;Biochemistry;Biogenesis;Biological Process;cell age;Cell Aging;Cell Physiology;Cells;Cellular Structures;Charge;Collaborations;Communities;Complement;Complex;Defect;design;Devices;Dimensions;Drosophila genus;Engineering;Event;Functional disorder;Genes;Genetic;Genetic Transcription;Goals;Grant;hallmarks of aging;Image;imaging modality;Individual;innovation;Investigation;Island;Left;Libraries;Link;Longevity;Lysosomes;Machine Learning;machine learning method;Maps;Membrane Potentials;Methods;Mining;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Mitochondrial Proteins;Molecular;Molecular Profiling;novel;Organelles;overexpression;Pathway interactions;pilot test;prevent;Proteins;Proteome;Proton Pump;Protons;receptor;Reporting;Research;Research Personnel;Resolution;Role;Saccharomycetales;Signal Transduction;Site;Time;tool;transcription factor;Transcriptional Activation;transmission process;vacuolar H+-ATPase;Vacuole;Work;yeast protein;Yeasts

PROJECT_TITLE: Multidimensional mapping of proteome changes and mechanisms underlying yeast replicative aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Data Science;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Homicide and Legal Interventions;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse;Violence Research

ORG_CITY: CHICAGO

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative The opioid crisis has shifted into a ‘fourth wave’ of high mortality, characterized by the mixture of synthetic opioids with stimulants. This project will integrate time-sensitive medicolegal death investigation data on fatal drug overdoses, which are currently unavailable to the public. We will leverage both structured and unstructured data from death certificate, toxicology, police, and coroner/medical examiner reports to identify points of intervention and prevention strategies to combat the rapidly evolving opioid crisis.

PI_NAMEs: POST, LORI ANN (contact)

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: access restrictions;Accidents;addiction;Address;Age;Agreement;analog;Censuses;Cessation of life;Characteristics;Cocaine;combat;comparative;Coroners and Medical Examiners;County;Criminal Justice;Data;Data Element;data exchange;Data Science;Data Set;data sharing;Databases;Death Certificates;Death Rate;Demography;Drug Combinations;Economics;epidemiologic data;Epidemiologist;Epidemiology;epidemiology study;Ethnic Origin;Event;Federal Government;Fentanyl;Foundations;Frequencies;Funding;Gender;Geographic Locations;Geography;Government Agencies;Health;Homicide;implementation science;Imprisonment;Individual;Informatics;Interdisciplinary Study;Intervention;Intoxication;Investigation;Law Enforcement;Location;Medical Examiners;Medical History;Medicine;men;Mental Health;Methamphetamine;Methods;mortality;novel therapeutics;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid use disorder;Overdose;overdose death;Persons;Pharmaceutical Preparations;Police;Policies;Prevention;Prevention strategy;Process;Public Health;Race;Recording of previous events;Records;Reporting;Research;Research Personnel;Resources;response;Role;Route;Rural;Secure;sex;Signal Transduction;Sociology;Source;State Government;Stimulant;stimulant use;Structure;structured data;Suicide;synthetic opioid;System;Time;Toxicology;United States;Universities;unstructured data;usability;Variant;Violence;Vital Statistics;Woman

PROJECT_TITLE: Leveraging state drug overdose data to build a comprehensive case level national dataset to inform prevention and mitigation strategies.


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Genetics;Liver Disease;Nutrition;Obesity;Prevention

ORG_CITY: SAN ANTONIO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: NARRATIVE The most abundant divalent cation, Mg2+, is essential for cellular functions and perturbations are associated with several clinical conditions, including obesity, cardiovascular diseases, diabetes, nonalcoholic fatty liver disease (NAFLD), chronic kidney disease, and cancer; however, the molecular events that directly link Mg2+ to metabolic disease progression are still elusive. Our proposed studies will reveal a previously unexplored mechanism linking mitochondrial Mg2+ dynamics to key hepatic metabolic pathways, which may offer new therapeutic approaches for the treatment of T2DM and comorbidities such obesity and NAFLD.

PI_NAMEs: BAUR, JOSEPH A.;MUNISWAMY, MADESH  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Ablation;Address;Adipocytes;Adipose tissue;Adopted;Animals;Biochemical;Biochemistry;Bioenergetics;Biological;biophysical techniques;blood glucose regulation;Body Composition;Body Weight;Brown Fat;candidate identification;Cardiovascular Diseases;Cell Physiology;Cells;Chronic Kidney Failure;Citrates;Clinical;comorbidity;CRISPR/Cas technology;Data;Detection;Development;Diabetes Mellitus;diet-induced obesity;dietary;dietary control;Disease;disease model;Disease Progression;Divalent Cations;Energy Metabolism;Eukaryota;Event;experimental study;Failure;Fatty acid glycerol esters;fatty acid oxidation;Fatty Liver;feeding;fibroblast growth factor 21;Functional disorder;Gene Expression Profile;Genetic;genetic approach;genetic regulatory protein;Glucose;glucose metabolism;glucose production;Glycolysis;Health;Hepatic;Hepatocyte;HIF1A gene;Homeostasis;Hyperglycemia;Impairment;In Vitro;in vivo;innovation;insight;interest;Intervention;Ion Channel;Knockout Mice;Ligands;Link;lipid biosynthesis;lipid metabolism;Lipids;Liver;liver function;liver metabolism;Liver Mitochondria;Magnesium;Malignant Neoplasms;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Migraine;Mitochondria;Mitochondrial RNA;Modeling;Molecular;mouse model;Mus;Nervous System Disorder;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Obesity;obesity prevention;oxidation;Pathologic Processes;Pathway interactions;Patients;pharmacologic;Phenotype;Physiological;Physiology;Plasma;Play;Pre-Eclampsia;preservation;Prevalence;prevent;Public Health;Quality Control;Regulation;respiratory;restoration;RNA Splicing;Role;Sepsis;Signal Transduction;small molecule;Stress;Structure;Testing;Therapeutic;transcriptome sequencing;treatment strategy;Triglycerides;uptake;Weight Gain;western diet

PROJECT_TITLE: Mechanisms and therapeutic potential of blocking the mitochondrial Mg2+ channel Mrs2 in obesity and NAFLD

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE This project will complete a longitudinal data infrastructure including most of the U.S. population from 1940 through 2020. The new data resource will enable health scientists to use information on early-life and ancestral experiences—such as parental economic status, childhood environmental exposures, policy conditions, social institutions, and neighborhood characteristics—to investigate of the health, well-being, and mortality of Americans over their lives and through generations.

PI_NAMEs: ALEXANDER, JOSEPH T. (contact);GENADEK, KATHERINE R

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Address;Affect;Aging;American;Behavioral;Biological;Birth;Birth Place;Censuses;Cessation of life;Characteristics;Child;Childhood;County;Couples;Data;data centers;data infrastructure;data resource;Data Set;Data Sources;Date of birth;Demography;Development;Economics;Education;Environmental Exposure;experience;functional status;Funding;Generations;Geography;Goals;Health;health data;Healthcare;Household;improved;Individual;Information Resources;Infrastructure;innovation;Institution;Investigation;Investments;late life;Life;Life Cycle Stages;Life Experience;Link;Longitudinal Studies;Medicaid;Methods;Modernization;mortality;Names;Neighborhoods;Outcome;Pathway interactions;Personal Satisfaction;Policies;Population;population based;population health;Process;Records;Reproductive Health;Research;Research Personnel;Research Priority;Resources;Respondent;Scientist;Security;Series;Services;social;social factors;Social outcome;Social Security Number;Surveys;Time;United States Social Security Administration;Use of New Techniques;Work;World War II;young adult

PROJECT_TITLE: Baseline Data for the Longitudinal Study of Aging

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cerebrovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Hypertension;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE  While stroke is the third leading cause of death among African Americans (AA) and blood-pressure is a major risk factor of stroke, genetic susceptibility to stroke and hypertension of AAs is less well studied than that of other ethnic groups. The objective of this study is to identify variants predicting various types of genomic features in AAs, and to integrate the functional regulation information into AA-specific genetic association analysis of stroke and blood pressure. Discovery of genetic variants that predispose to stroke and blood pressure is a crucial step toward understanding genetic mechanisms that may lead to novel prevention and treatment strategies in this under-studied ethnic group.

PI_NAMEs: HSU, LI  (contact);KOOPERBERG, CHARLES L;REINER, ALEXANDER P

PROGRAM_OFFICER_NAME: JAQUISH, CASHELL E

PROJECT_TERMS: African American;African American population;African ancestry;American;Blood Pressure;Cause of Death;Characteristics;Clinical;Complex;Computer software;Data;demographics;Detection;Diastolic blood pressure;Disease;Disparity;Elements;Encyclopedia of DNA Elements;ethnic diversity;Ethnic Origin;Ethnic Population;European;European ancestry;Gene Expression;Genetic;genetic association;Genetic Predisposition to Disease;Genetic study;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;genome-wide analysis;genomic locus;genomic predictors;Genomics;Genotype;Goals;Health behavior;Heritability;Hypertension;improved;Incidence;Individual;insight;Mediating;Methods;Methylation;Minority;Modeling;Molecular;Motivation;Nature;novel;open source;Pathway interactions;pleiotropism;Population;Prevention strategy;Proteins;Proteomics;public repository;Quantitative Trait Loci;racial population;Regulation;Risk;Risk Factors;Sample Size;Sampling;social determinants;Socioeconomic Status;Statistical Methods;statistics;Stroke;stroke risk;Tissues;trait;Trans-Omics for Precision Medicine;transcriptome sequencing;treatment strategy;Variant;Work

PROJECT_TITLE: Integrative Genomics into Genetic Association Studies of Blood Pressure and Stroke in African Americans

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The inability to target preventive therapy to children at highest risk of tuberculosis (TB) progression is a major barrier to its scale-up in high burden countries. This study will identify novel host biomarkers and determine the best biomarker panels (i.e., biosignatures) that can meet the World Health Organization-recommended diagnostic accuracy thresholds for a test of TB progression in young children. If successful, the results will be the first step needed to make progress toward addressing the critical unmet need for better tests to target TB preventive therapy.

PI_NAMEs: CATTAMANCHI, ADITHYA  (contact);ERNST, JOEL D.

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: 5 year old;Acute;Address;Adolescent;Adult;Antibodies;Antibody Response;Antigen-Antibody Complex;Antigens;B-Lymphocytes;biobank;Bioinformatics;bioinformatics pipeline;Biological;Biological Assay;Biological Markers;biomarker discovery;biomarker identification;biomarker panel;biomarker signature;biosignature;Blood Banks;Candidate Disease Gene;candidate identification;candidate marker;Cell Death;Cells;Cessation of life;Characteristics;Child;Childhood;Clinical;clinically relevant;cohort;Country;diagnostic accuracy;Disease;Disease Progression;Early Diagnosis;Early treatment;Evaluation;field study;Funding;Gambia;Gene Expression Profile;Genes;Genetic Transcription;Growth;high risk;HIV;human model;Immune;Immunologic Sensitization;Immunologics;immunopathology;In Vitro;in vivo;Infection;Injury;insight;ion mobility;Link;Machine Learning;Mass Spectrum Analysis;Measures;metabolomics;mouse model;Mouse Strains;multiple omics;mycobacterial;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;National Institute of Allergy and Infectious Disease;next generation;novel;novel marker;Pathogenesis;Pathway Analysis;Pathway interactions;Performance;Phage ImmunoPrecipitation Sequencing;Plasma Cells;point of care;point of care testing;Predictive Value;Preventive therapy;Preventive treatment;Proteins;Proteome;Proteomics;Recommendation;Research;Resolution;response;RNA;Role;Sampling;scale up;Secondary to;segregation;South Africa;Specific qualifier value;Subgroup;System;targeted biomarker;Testing;Therapy trial;tissue injury;Tissues;Training;Translating;Tuberculosis;Tuberculosis diagnosis;tuberculosis immunity;Uganda;Urine;Vietnam;Viral Respiratory Tract Infection;Whole Blood;World Health Organization

PROJECT_TITLE: PROgression of Tuberculosis infECTion in young children living with and without HIV: the PROTECT study


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Disability Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative The objective of the present proposal is to transform the design experience for BME undergraduates at UAB, from freshman to senior year. Activities include a new freshman/sophomore clinical innovation course, a summer clinical immersion for rising juniors, and enhanced design and engineering content in the senior capstone experience. Direct exposure to clinicians and their problems, using clinical matchmaking software developed at UAB, will provide invaluable experiences in needs finding, customer discovery, and the development of engineering solutions that have market potential.

PI_NAMEs: EBERHARDT, ALAN W. (contact);TYLER, WILLIAM J

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Acceleration;Address;aging population;Alabama;Berry;Biomedical Engineering;Businesses;Clinical;Collaborations;commercialization;Comprehension;Computer software;Coupled;course sequence;Creativeness;design;Development;Device or Instrument Development;Devices;disability;Disabled Persons;disabled students;early experience;Education;Educational Curriculum;Educational process of instructing;Engineering;engineering design;Entrepreneurship;experience;Exposure to;Faculty;Feedback;Fostering;Foundations;Free Will;Healthcare Systems;Hospitals;Immersion;improved;innovation;Instruction;interdisciplinary approach;Learning;learning outcome;lectures;Marketing;Medical;Medical Device;Medical Technology;Medicine;Mission;Modeling;multidisciplinary;neurosurgery;novel;Orthopedic Surgery;Output;pandemic disease;Participant;Procedures;Process;product development;programs;prototype;provider communication;Public Health;satisfaction;Science;Self-Help Devices;Services;simulation;skills;software development;Student recruitment;Students;success;Technology;Thinking;Time;Translating;undergraduate education;undergraduate student;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Transforming the BME Design Experience from Freshman to Senior Year


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: DETROIT

ORG_DEPT: PEDIATRICS

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE We aim to determine the clinical utility of ‘dynamic tractography’: a novel method for visualizing electrical neural transfers that incorporates the underlying white matter tracts and supporting linguistic processing. We will also determine how well objective electrophysiology biomarkers will improve the prediction of language outcomes following epilepsy surgery. This project will ultimately optimize understanding of how the human brain develops its language network dynamics.

PI_NAMEs: ASANO, EISHI  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: 3-Dimensional;Acute;Adult;Age;age related changes;Anatomy;animation;Anterior;Area;Atlases;Auditory;Auditory Perception;auditory stimulus;Behavior;Biological Markers;Brain;Brain Mapping;Brain region;Childhood;Clinical;clinical practice;Code;cognitive function;cohort;Coupled;Coupling;Data;Development;Diffusion Magnetic Resonance Imaging;Dimensions;Dissociation;Electric Stimulation;Electroencephalography;Electrophysiology (science);Epilepsy;Evaluation;Event;Fiber;Frequencies;Goals;Grant;High Frequency Oscillation;Human;improved;Individual;individual patient;innovation;Language;Language Disorders;language outcome;lexical;lexical retrieval;Linguistics;Location;machine learning model;Magnetic Resonance Imaging;Maps;Methods;Modeling;Morphologic artifacts;Movement;Names;neural;Neurobiology;Neuropsychology;neurosurgery;novel;Older Population;Operative Surgical Procedures;Outcome;Parietal;Pathologic;Pathway interactions;patient subsets;Patients;Performance;Phase;Phonetics;Physiologic pulse;Physiological;Postoperative Period;predictive modeling;preservation;programs;prospective;recruit;resilience;response;Seizures;sound;Speech Sound;Stimulus;Superior temporal gyrus;Techniques;Temporal Lobe;Testing;Time;tractography;Validation;Visual;Visualization;white matter;white matter damage

PROJECT_TITLE: Functional brain mapping in pediatric neurosurgery

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dementia;Depression;HIV/AIDS;Heart Disease;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Almost half of all people diagnosed with HIV in the United States are older than 50 years and are expected to live near normal life expectancies given effective antiretroviral therapy; however, people aging with HIV are at increased risk for dementia, as well as depression and cardiovascular disease. In this project, we will develop a multimorbidity simulation model for dementia, depression, cardiovascular disease, and HIV and will use the model to project chronic disease outcomes, quality of life, and costs associated with aging. The overall goal is to investigate the long-term clinical and economic consequences of different strategies to reduce dementia and multimorbidity among people aging with HIV.

PI_NAMEs: HYLE, EMILY PARKER (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Advocate;Age;Age Years;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;antiretroviral therapy;Area;Cardiovascular Diseases;cardiovascular disorder prevention;care costs;Caring;Chronic Disease;Clinical;clinical care;Clinical Trials;clinically relevant;cohort;Cohort Studies;Collaborations;comorbidity;cost;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost of dementia;Cost of Illness;cost outcomes;Data;Dementia;dementia risk;depression model;design;Development;Diagnosis;Disease;disease model;Disease Outcome;economic outcome;Economics;effective therapy;Epidemiology;Etiology;Event;evidence base;experience;Functional disorder;Future;General Population;Goals;Guidelines;Health Care Costs;Heart;high risk;HIV;Impaired cognition;improved;Incidence;Individual;innovation;interest;International;Intervention;Life Expectancy;life time cost;Major Depressive Disorder;Mental Depression;Mental Health;Methods;Modeling;models and simulation;modifiable risk;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;multiple chronic conditions;National Institute on Aging;Neurocognitive;novel;Outcome;Patients;Persons;Policies;Population;prevent;Prevention;Prevention strategy;Public Health;Quality of life;Recording of previous events;Research;Resources;Risk;Risk Factors;Strategic vision;Structure;synergism;Time;Treatment Effectiveness;United States;Update;Vulnerable Populations

PROJECT_TITLE: The CHARMED model: a multimorbidity simulation model for people aging with HIV

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NORMAN

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: The emergence of multi-drug resistance in already challenging Gram-negative infections and the dry pipeline of broad-spectrum antibiotics demand alternative strategies to preserve activities of clinical antibiotics. This project is focused on development of a promising approach to inhibit multidrug efflux pumps. If successful, studies will identify novel efflux inhibitors with desired biochemical activities and primed for specific clinical applications.

PI_NAMEs: ZGURSKAYA, HELEN I (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acinetobacter baumannii;Address;Affect;antibiotic efflux;Antibiotic Resistance;Antibiotics;Area;Bacteria;Bacterial Infections;Biochemical;Cell Membrane Permeability;Chemosensitization;Chimeric Proteins;chronic infection;Clinical;clinical application;clinical development;Colistin;Complex;design;Development;drug discovery;Drug Efflux;Dryness;efflux pump;Escherichia coli;experimental study;Funding;Goals;Infection;inhibitor;insight;Kinetics;Knowledge;Libraries;Membrane;Membrane Fusion;Modeling;Molecular;Molecular Conformation;Multi-Drug Resistance;multidisciplinary;Multidrug-resistant Acinetobacter;Multiple Bacterial Drug Resistance;novel;Pathogenesis;periplasm;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;preclinical study;preservation;Proteins;Pump;Research;Resistance;resistance mechanism;resistant strain;response;Role;Series;simulation;Structure;Structure-Activity Relationship;Therapeutic;therapeutic target;tool;Toxic effect;Virulence

PROJECT_TITLE: Transport across two membranes by AcrAB-TolC

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: MILWAUKEE

ORG_NAME: UNIVERSITY OF WISCONSIN MILWAUKEE

PHR: PROJECT NARRATIVE  The  ABCD  Study  consortium  uses  multimodal  brain  imaging,  cognitive  and  clinical  assessments,  bioassays,  mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and  social functioning in 11,878 9- 10 year- olds to be followed over 10 years, to determine the effects of substance  use  on  adolescent  brain  and  cognitive  development.  This  ABCD  Research  Project  Site  will  follow  and  assess  participants  enrolled  in  the  study.  These  data  will  be  shared  with  the  scientific  community  to  address  a  comprehensive range of questions concerning youth development.

PI_NAMEs: LARSON, CHRISTINE L;LISDAHL, KRISTA MAURINE (contact)

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 11/21 ABCD-USA Consortium: Research Project Site at UWM


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: Project Narrative  Neurons are among the most long-lived cell types in our bodies, as they are generally never replaced and must a maintain function for our entire lifetime. One vital aspect of maintaining neuronal health is the preservation of a healthy pool of the energy-producing organelle within the cell, the mitochondria, as multiple neurodegenerative diseases are caused by defects in mitochondrial function. The work in this proposal will study a newly discovered way in which neurons break down their damaged mitochondria through outsourcing this breakdown process to their cellular neighbors known as glial cells.

PI_NAMEs: INSOLERA, RYAN  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TITLE: Mechanistic investigation of in vivo pathways of neuronal mitochondrial degradation

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: DAVIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Second generation antipsychotics (SGAs) produce highly variable effect/side effect profiles in patients, and most patients cycle through several medications before finding one with a tolerable therapeutic window. I propose that differences in receptor signaling and trafficking properties at the D3 dopamine receptor in response to distinct SGAs contributes to their variable effects. My research will refine our understanding of a non-canonical signaling pathway directly impacted by SGAs and could ultimately inform new avenues for more effective treatment of neuropsychiatric conditions.

PI_NAMEs: KEESHEN, CAROLINE MARIE (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Acute;Affect;Affinity;Agonist;antagonist G;Antipsychotic Agents;Arrestins;Axon;Behavior;behavior measurement;Behavioral;Behavioral Model;Binding;Biological Assay;Biological Models;Bipolar Disorder;Cell model;Cells;Chronic;Clinical;Clozapine;Clozaril;Cognitive;Coupled;Couples;desensitization;Detection;Development;Dopamine;Dopamine D2 Receptor;dopamine D3 receptor;Dopamine Receptor;effective therapy;Electrophysiology (science);Endocytosis;Event;Exhibits;experimental study;Family;flexibility;G-Protein-Coupled Receptors;Generations;Goals;GTP-Binding Proteins;Impairment;improved;In Vitro;in vivo;insight;Ligand Binding;Ligands;LoxP-flanked allele;MAPK3 gene;Mediating;Mental Depression;Midbrain structure;mimetics;Molecular;Motor Activity;Mus;mutant;Mutation;Names;neural;neuropsychiatry;neuroregulation;next generation;novel therapeutics;Outcome;patch clamp;patient population;Patients;Pharmaceutical Preparations;Phosphorylation;Phosphorylation Site;Phosphotransferases;Population;pre-clinical;Prefrontal Cortex;prepulse inhibition;prevent;profiles in patients;Property;protein activation;Protein Kinase C;protein kinase C kinase;Protein Sortings;quetiapine;Quinpirole;radioligand;receptor;Receptor Down-Regulation;receptor downregulation;Receptor Signaling;Receptor Up-Regulation;receptor upregulation;recruit;Research;Resistance;response;scaffold;Schizophrenia;Second Messenger Systems;Serine;Seroquel;severe mental illness;side effect;Signal Pathway;Signal Transduction;Signaling Protein;Site-Directed Mutagenesis;stable cell line;Startle Reaction;System;Testing;Therapeutic;Threonine;Time;trafficking;Work

PROJECT_TITLE: Molecular determinants of Arrestin-mediated dopamine D3R modulation of the T-type Ca2+ channel CaV3.2


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Natural Products

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Narrative Fundamental new synthetic approaches and new synthetic methodology and their use in the discovery of new therapeutics for the treatment of cancer will emerge from the studies, and a fundamental understanding of the mechanism of action and the interaction of biologically active natural products with their biological target will be developed. New approaches to the synthesis of vinblastine and related new drugs that improve on the potency, selectivity, and efficacy of clinically used natural products (vinblastine and vincristine) will be discovered, including those that are active against vinblastine-resistant and multidrug-resistant (MDR) tumors.

PI_NAMEs: BOGER, DALE L (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: ABCB1 gene;Address;Affinity;Alkenes;analog;antineoplastic antibiotics;ATP-Binding Cassette Transporters;Binding;Biological;Biology;cancer therapy;Catalysis;Cells;Chemicals;Clinic;Clinical;clinical efficacy;Complex;Coupling;cycloaddition;cyclopropenone;depolymerization;design;Development;Diels Alder reaction;dimer;DNA Binding;Dose Limiting;Drug Efflux;effective therapy;Electron Transport;Electrons;Evaluation;Grant;Human;Hydrogen;Hydrogen Bonding;improved;Indoles;innovation;insight;Investigation;Isomerism;ketal;Mediating;Medicine;member;Methodology;Microtubules;Mitosis;Modern Medicine;Molecular;Multi-Drug Resistance;multidrug resistant cancer;Natural Product Drug;Natural Products;novel strategies;novel therapeutics;Oncology;Organic Synthesis;overexpression;Oxadiazoles;Pharmaceutical Preparations;pre-clinical;programs;propadiene;Property;protein protein interaction;Proteins;Protocols documentation;Reaction;Refractory;Resistance;Resistance profile;Site;Solvents;Source;Structure;Therapeutic;Toxic effect;Triazines;Tubulin;tumor;Vinblastine;vinblastine analog;Vinca Alkaloids;Vincristine

PROJECT_TITLE: Antitumor Antibiotics

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: RELEVANCE Deep brain stimulation (DBS) is a powerful clinical technology, positively impacting the lives of tens of thousands of patients worldwide. However, DBS surgical targeting technology and post-operative programming practices have been relatively stagnant over the history of the therapy. We propose that new tools are needed to analyze the effects of stimulation on individual patients and evaluate novel stimulation strategies. Therefore, the goal of this project is to apply the latest advances in magnetic resonance imaging, DBS computational modeling, and holographic visualization to the clinical practice of subthalamic DBS for the treatment of Parkinson’s disease.

PI_NAMEs: MCINTYRE, CAMERON  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 3-Dimensional;Anatomy;Axon;Biomedical Engineering;Brain;Clinical;clinical practice;Complex;Computer Models;Data;Data Set;Deep Brain Stimulation;Devices;Dictionary;Dimensions;Electrodes;Evolution;Fingerprint;Frequencies;Goals;Hand;hologram;holographic model;holographic visualization;Holography;Image;improved;individual patient;individualized medicine;interest;Link;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Measurement;Methods;Modeling;Modernization;motor symptom;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Navigation System;Neurologist;Neurosurgeon;neurosurgery;novel;novel strategies;Operative Surgical Procedures;Parkinson Disease;Pathway interactions;Patients;Perioperative;Physiologic pulse;Population;Postoperative Period;Procedures;Property;Protocols documentation;Quality of life;Quantum Mechanics;reconstruction;Recording of previous events;Research;Research Project Grants;Research Subjects;Resolution;Running;Scientific Advances and Accomplishments;Signal Transduction;Stimulus;Structure of subthalamic nucleus;System;Technology;Therapeutic;three-dimensional visualization;Time;tissue mapping;Tissues;tool;Translating;Update;Visualization

PROJECT_TITLE: Application of Advanced Imaging and Visualization to Clinical Deep Brain Stimulation

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Project Narrative RNA viruses like SARS-CoV-2 cause devastating impacts on public health, the economy, and our daily lives in the U.S. and worldwide. To fight these pathogens, scientists need simple techniques to study the effect of viral mutations and how they impact disease severity, transmission, or evasion of vaccine- or natural-derived immunity. These studies will develop novel techniques and tools, enabling more scientists to research how mutations impact viruses and may serve as the basis for future vaccine candidates or diagnostic tools.

PI_NAMEs: WEGER, JAMES D (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;airway epithelium;Applied Research;Attenuated Vaccines;Bacteria;Basic Science;Biology;Biomedical Research;burden of illness;Bypass;Cells;Circular DNA;Clonality;Cloning;Communities;Complementary DNA;Coronavirus;Data;Databases;deep sequencing;Dengue Vaccine;Dengue Virus;Dengvaxia;diagnostic tool;Disease;DNA;DNA biosynthesis;DNA chemical synthesis;DNA Viruses;empowerment;Epithelial Cells;Escherichia coli;Family;fighting;Flaviviridae;Flavivirus;fundamental research;Future;Genetic;Genetic Determinism;Genome;Genotype;Goals;Growth;Human;Immune Evasion;Immunity;In Vitro;innovation;Kinetics;Link;Measures;Mediating;Methods;Mission;Molecular;Molecular Virology;mutant;Mutation;Nose;novel;novel strategies;pathogen;Pathogenesis;Phenotype;Plasmid Cloning Vector;Plasmids;Point Mutation;Polymerase;promoter;Protocols documentation;Public Health;Reaction;recombinant virus vaccine;Recombinants;reconstitution;Reporter;Research;Resource Sharing;Resources;reverse genetics;RNA Viruses;SARS-CoV-2 B.1.1.529;SARS-CoV-2 variant;Scientist;Serotyping;Severe Acute Respiratory Syndrome;Severity of illness;System;Techniques;tool;Toxic effect;transmission process;Tube;United States National Institutes of Health;vaccine candidate;Vaccines;variants of concern;Viral;Viral Genome;virology;Virus;Virus Assembly;virus genetics;Virus Replication;Work;Yeasts

PROJECT_TITLE: An innovative and straightforward approach to construct and manipulate viral infectious clones

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE The Genomics Research Experience for Master’s Students (GEMS) Fellows R25 summer research program will train students enrolled a master’s degree in biostatistics, statistics, data science, computer science or related quantitative discipline in sophisticated statistical and computational methods for the analysis of cancer genomics data and precision oncology. GEMS is hands-on, immersive and interdisciplinary with several components that make the program unique: access to the world's leading resources of cancer genomics data and tools; dual- mentorship team science model by Memorial Sloan Kettering (MSK) faculty comprising basic, translational, biostatistical, epidemiological and clinical scientists who are leaders in their fields; student pairing with a peer advisor; and a lecture/mini workshop series on cutting-edge genomic technologies and high dimensional data analysis given by program faculty who are world experts. GEMS fellows will execute an impactful research project as well as experience scientific discovery through collaborative multidisciplinary team science.

PI_NAMEs: PANAGEAS, KATHERINE S (contact);SHEN, RONGLAI

PROGRAM_OFFICER_NAME: ZAHIR, NASTARAN

PROJECT_TERMS: Academia;Address;biomarker discovery;Biomedical Research;Biometry;Brain Drains;cancer genomics;career;career development;Clinical;Clonal Evolution;Complex;computer infrastructure;computer science;Computing Methodologies;Data;Data Analyses;data resource;Data Science;Data Scientist;Decision Making;Degree program;Development;Discipline;disease classification;DNA;Education;Educational workshop;Enrollment;Environment;Epidemiology;Evaluation;experience;Exposure to;Faculty;Feedback;Fellowship;Fellowship Program;follow-up;frontier;Genomic approach;genomic data;genomic tools;Genomics;Goals;hands on research;high dimensionality;Individual;Industry;Internships;Interview;knowledge translation;Learning;lectures;Letters;Malignant Neoplasms;Master of Science;Medicine;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;Methodology;Methods;Modeling;Modernization;multidimensional data;multidisciplinary;multimodality;neoplasm resource;next generation;next generation sequencing;parallel computer;Participant;Patients;peer;Performance;Population;precision oncology;Process;Program Evaluation;programs;prospective;Proteins;Recommendation;Records;recruit;Reproducibility;Research;Research Project Grants;Research Training;risk stratification;RNA;Science;Scientist;Series;single cell genomics;skills;Statistical Methods;statistics;Structure;student training;Students;success;summer internship;summer research;Surveys;Techniques;Technology;theories;Time;tool;Training;training data;transcriptome;Translating;Translational Research;Tumor Biology;whole genome

PROJECT_TITLE: Genomics Research Experience for Master's Students (GEMS) Fellowship

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: HOUSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: NARRATIVE Understanding the process of atherosclerosis and its progression is essential to decrease cardiovascular disease burden. Our goal is to use multi-omics technologies to identify novel genetic determinants and metabolites associated with atherosclerosis so that more efficacious intervention strategies can be appropriately administered. The results of this research will enable continued scientific progress toward an understanding of cardiovascular disease etiology.

PI_NAMEs: YU, BING  (contact)

PROGRAM_OFFICER_NAME: YAN, YE

PROJECT_TERMS: adjudication;African;African American population;Atherosclerosis;atherosclerosis risk;Atherosclerosis Risk in Communities;biobank;Biochemical Pathway;Bioinformatics;Biological;Biometry;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;Carotid Arteries;Cause of Death;clinical risk;Cloud Computing;coronary artery calcium;Coronary Artery Risk Development in Young Adults Study;Coronary heart disease;Data;Development;Diet;Education;effective intervention;efficacious intervention;Environment;Ethnic Origin;Ethnic Population;Etiology;European;Event;Exhibits;Framingham Heart Study;Functional disorder;Future;gene product;genetic architecture;Genetic Determinism;genetic variant;genome sequencing;Genomics;Goals;high risk;Hispanic Americans;Hispanic Community Health Study/Study of Latinos;Human;Impairment;Incidence;Individual;Inflammation;Inflammatory;Infrastructure;Intervention;Intervention Studies;intimal medial thickening;Jackson Heart Study;Knowledge;late life;Life Style;Link;Lipids;Measures;Mediating;Mendelian randomization;Metabolic;Metabolic dysfunction;Metabolism;metabolome;metabolomics;middle age;Minority;Modeling;Molecular;Morbidity - disease rate;mortality;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;multiple omics;novel;oxidation;Pathway interactions;Physical activity;polygenic risk score;Positioning Attribute;prevent;Prevention;Process;programs;Research;Resources;Risk Factors;Role;secondary analysis;sex;Single Nucleotide Polymorphism;social determinants;Stroke;Technology;Testing;Time;trait;Trans-Omics for Precision Medicine;Variant;whole genome;Work

PROJECT_TITLE: Molecular Determinants of Atherosclerotic Cardiovascular Disease in Multi-ethnic Populations

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Narrative The Nonhuman Primate Reagent Resource (NHPRR) develops, manufactures, and distributes research reagents for more than 21 years. These species-matched immunologic tools help investigators develop and utilize preclinical monkey models of human diseases–from infectious diseases to organ transplantation. This application describes the scientific and operational goals for our resource program's next cycle, using new reagent development methodologies and expanded community outreach plans to maximize the NHPRR's impact in nonhuman primate research.

PI_NAMEs: ENGELMAN, KATHLEEN ;MAGNANI, DIOGO  (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Acceleration;Animal Model;Animals;Antibodies;antibody detection;Biological;Biological Markers;Biological Response Modifier Therapy;Biological Testing;Cells;Communicable Diseases;Communities;Community Outreach;Data;Databases;design;Development;Development Plans;Discipline;Disease;disease model;Electronics;Engineering;Five-Year Plans;Formulation;Future;Goals;Human;human disease;human model;Immune;Immunologics;Immunomodulators;immunoregulation;improved;in vivo;in-vitro diagnostics;Infrastructure;large scale production;manufacture;Methodology;Modeling;Monkeys;Monoclonal Antibodies;Names;Natural Killer Cells;next generation;nonhuman primate;novel;novel therapeutics;operation;Organ Transplantation;outreach;Pathogenesis;Peptide Hydrolases;Population;pre-clinical;Production;programs;Quality Control;Reaction;Reagent;Recombinant Antibody;Recombinants;Records;Research;Research Personnel;Resources;response;Role;Scientific Advances and Accomplishments;Services;Source;Technology;tool;Translational Research;Vaccines;web site

PROJECT_TITLE: Nonhuman Primate Reagent Resource


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Social Determinants of Health;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Repeated cycles of binge alcohol intoxication and withdrawal are associated with impaired social behaviors, compounding interpersonal problems associated with alcohol abuse and hastening the progression to alcohol use disorder (AUD). Unfortunately, few treatment options are currently available that specifically address the social symptoms of alcohol abuse. This study will employ a rodent model of binge alcohol consumption to elucidate serotonergic mechanisms of alcohol’s deleterious effect on social behavior, with an eye toward developing new treatments for AUD.

PI_NAMEs: FLANIGAN, MEGHAN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: 3-Dimensional;Abstinence;Acute;Address;Affective;alcohol abstinence;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol effect;alcohol exposure;alcohol relapse;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholic Intoxication;Alcohols;Award;Back;Behavior;Behavioral;binge drinking;Brain;Buffers;Cell Nucleus;Cell Physiology;cell type;Cells;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;COVID-19 pandemic;Darkness;Data;design;Development;drinking;Electrophysiology (science);Equilibrium;experience;experimental study;Female;Fiber;Foundations;Future;G alpha q Protein;Gene Expression;Generations;Genetic;genetic manipulation;Habenula;Heavy Drinking;hindbrain;impaired driving performance;Impairment;in vivo;Individual;knock-down;Lateral;Medial;Mediating;Modeling;Molecular;Mood Disorders;Mus;negative emotional state;neurobiological mechanism;neuronal excitability;Neurons;neuroregulation;novel;overexpression;patch clamp;Patients;Pattern;Persons;Phase;Photometry;Physiological;Physiological Adaptation;Physiological Processes;Physiology;prevent;programs;receptor;receptor expression;Receptor Signaling;Recording of previous events;Regulation;Relapse;Research;Research Personnel;response;Rewards;Risk;Rodent;Rodent Model;Role;Serotonin;serotonin receptor;sex;Signal Transduction;skills;social;Social Behavior;Social Behavior Disorders;social deficits;Social Functioning;Social Interaction;Social Problems;Social support;Stimulus;Substance Use Disorder;Symptoms;System;targeted treatment;Technical Expertise;Techniques;Testing;tool;Training;transcriptomics;translating ribosome affinity purification and RNA-sequencing;translatome;Treatment outcome;Viral;virus genetics;Woman

PROJECT_TITLE: Regulation of alcohol-induced social disturbances by lateral habenula serotonin receptors

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Racial and Ethnic Minority Health Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative The objective of this program is to train clinical and translational physician-scientists to develop new cancer treatments and improve cancer care delivery at the Montefiore Einstein cancer center. This will be achieved through a coordinated program of mentoring, innovative didactic courses, and emphasis on diversity based equity care delivery for underserved population via an interdisciplinary collaborative design.

PI_NAMEs: SAENGER, YVONNE MARGARET;VERMA, AMIT K. (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Albert Einstein Cancer Center;Basic Science;Biometry;cancer care;Cancer Center;cancer research center director;care delivery;career;Catchment Area;Clinical Investigator;Clinical Oncology;Clinical Research;Clinical Trials;community engagement;Community Outreach;comparative effectiveness;design;Development;Discipline;Doctor of Medicine;Doctor of Philosophy;Ecosystem;Educational Curriculum;Educational workshop;Enrollment;Equity;Evaluation;Funding;Goals;Grant;Immunotherapy;Institution;Investigational Therapies;K-Series Research Career Programs;Leadership;Liquid substance;Malignant Neoplasms;medical schools;Medicine;Mentored Clinical Scientist Development Program;Mentors;Minority;Minority Groups;Modeling;next generation;novel;Oncology;Outcome;Participant;patient oriented;Population;Population Heterogeneity;Positioning Attribute;Principal Investigator;programs;Publications;Qualifying;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;senior faculty;Solid Neoplasm;Therapeutic;Therapeutic Research;Training;Training Programs;Translational Research;translational scientist;underserved minority;Wages;Writing

PROJECT_TITLE: Diversity-focused Montefiore Einstein Clinical Oncology Training Program in the Bronx


ADMINISTERING_IC: ES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: RALEIGH

ORG_DEPT: BIOLOGY

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: NARRATIVE The aim of the Center for Human Health and the Environment is to understand how human health, at both the individual and population level, is impacted by environmental factors and to implement this knowledge to prevent and/or reduce the adverse impacts of environmental factors on human health.

PI_NAMEs: FENTON, SUE  (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Affect;Area;Award;Back;base;Basic Science;Behavior;Bioinformatics;Biological;Biology;career;career development;Cells;Cellular biology;Collaborations;Communication;Communities;community engagement;community partners;Comparative Pathology;Consultations;Core Facility;cost;Data Science;Dedications;Discipline;Engineering;Environment;Environmental Exposure;Environmental Health;Environmental Impact;Environmental Risk Factor;environmental stressor;Epidemiology;Epigenetic Process;epigenome;Exposure to;Extramural Activities;Fostering;Funding;Future;Genes;Genetic;Genome;Genomics;Grant;Health;health science research;Health Sciences;Human;human disease;Image;improved;Individual;Infrastructure;innovation;Institution;instrumentation;Integrative Medicine;Interdisciplinary Study;Interest Group;Investments;Knowledge;Leadership;Link;literacy;lung health;medical schools;member;Mentors;metabolomics;Metal exposure;Mission;model organism;multidisciplinary;multiple omics;National Institute of Environmental Health Sciences;Neurosciences;Neurosciences Research;next generation;North Carolina;Organ;Outcome;Paper;Pathologic;Pathway interactions;Phenotype;Philosophy;Physics;Pilot Projects;Poly-fluoroalkyl substances;Population;Population Sciences;Population Study;prevent;Productivity;Program Development;programs;Proteomics;Public Health;Publishing;Research;Research Personnel;Research Project Grants;Resources;Science;statistics;stressor;success;synergism;Systems Biology;Technology;technology platform;Tissues;toxic metal;Toxicology;Training;Translational Research;Translations;Underrepresented Populations;United States National Institutes of Health;Universities;Veterinary Medicine;Vision;Visualization;Woman

PROJECT_TITLE: Center for Human Health and the Environment (CHHE)

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(P)]


NIH_SPENDING_CATS: Social Determinants of Health

PROJECT_TERMS: Affect;Area;Behavior;career;career development;Clinical;Communication;Communities;cost effective;Ensure;Environment;environmental enrichment for laboratory animals;Environmental Exposure;Environmental Health;Environmental Impact;environmental stressor;Epigenetic Process;Extramural Activities;Fostering;Funding;Future;Genetic;Goals;Grant;Health;health science research;Historically Black Colleges and Universities;Human;human disease;improved;Information Centers;Infrastructure;instrumentation;interdisciplinary collaboration;Interest Group;Knowledge;Leadership;lung health;medical schools;member;mid-career faculty;Mission;Neurosciences;news;North Carolina;Outcome;Pilot Projects;Population;Program Development;programs;Public Health;Research;Research Personnel;Research Project Grants;Services;success;Technology;technology platform;Training;Translational Research;Translations;transmission process;Travel;Underrepresented Populations;Universities;voucher;Woman

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS]


NIH_SPENDING_CATS: Data Science

PI_NAMEs: COLLIER, DAVID  (contact)

PROJECT_TERMS: Affect;Basic Science;Bioinformatics;Biological Models;Clinical;Clinical Research;Communication;Communities;community engagement;community organizations;community partners;Core Facility;Data;data curation;data integration;data management;Data Science;data science resource;Data Scientist;data streams;data visualization;Dedications;Discipline;Ensure;Environment;Environmental Exposure;Environmental Health;Environmental Impact;Epidemiologist;Epidemiology;experimental study;Funding;Goals;Health;health data;health science research;Health Sciences;Human;Human Resources;human study;improved;Institution;Integrative Medicine;Interdisciplinary Study;International;knowledgebase;Libraries;Link;member;method development;Mission;Modeling;Population;Population Study;Prevention;Public Health;public health priorities;Research;Research Personnel;Resources;Sampling;Scientist;Specialist;Structure;success;System;Tissues;Translating;Translational Research;Translations

PROJECT_TITLE: Integrated Health Sciences Facility Core


NIH_SPENDING_CATS: Genetics

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative To capture the landscape of somatic mutations at the single-molecule level from a range of cell or DNA input using Tn5 transposase, the proposed research aims to develop a Tn5 based duplex sequencing (Tn5-duplex-seq) method in a single-well workflow, which resolves complementary strands by strand orientation from simple PCR-based capture. Tn5-duplex-seq technology can transform our understanding of somatic mutations through the innate comprehensiveness of this technique, by capturing both clonal as well as the rarest somatic mutations, and providing the basis for determining somatic single base or structural variation accurately. Ultimately, our tool will be accessible, cost-effective, and scalable to be used by the larger scientific community and easily integrated with pipelines of the Somatic Mosaicism across Human Tissues (SMaHT) Network.

PI_NAMEs: CHOUDHURY, SANGITA  (contact);LEE, EUNJUNG ALICE;WALSH, CHRISTOPHER A.

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Aging;Alleles;analytical method;analytical tool;base;Benchmarking;Bioinformatics;Brain;Cataloging;Catalogs;Cell Nucleus;cell preparation;cell type;Cells;Communities;computerized tools;Consensus;Copy Number Polymorphism;cost;cost effective;cost effectiveness;Data;Data Analyses;data analysis pipeline;Detection;Development;Disease Progression;DNA;DNA Repair;DNA Sequence Alteration;DNA sequencing;experience;flexibility;genetic profiling;Genome;Germ Layers;Heart;Human;Human Biology;Human Development;Human Genome;human tissue;Individual;Informatics;insertion/deletion mutation;Institution;Knowledge;life span;Medicine;Methods;Microsatellite Repeats;Mosaicism;Mutation;Mutation Spectra;Nature;Nucleotides;Pattern;Phase;Preparation;preservation;prevent;Procedures;Quality Control;rare variant;Research;Resolution;Sampling;scale up;single molecule;Single Nucleotide Polymorphism;Somatic Mutation;Standardization;Techniques;Technology;technology development;Technology Transfer;Tissues;Tn5 transposase;tool;Validation;Variant

PROJECT_TITLE: Detection and Characterization of Somatic Mutations in Human Tissue Utilizing Duplex-Consensus Sequencing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-K(70)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Relevance to Public Health Biomarkers for pre-clinical stages of Alzheimer's disease (AD) have become increasingly important for the development of preventative interventions. For neuroimaging, positron emission tomography (PET) imaging of amyloid beta (Aβ) and tau protein provide early imaging markers of AD and can track disease progression but are expensive and require the use of radioactive tracers. This project aims to develop and evaluate a noninvasive, quantitative and economical imaging marker of AD based on the complexity or regularity of resting state functional magnetic resonance imaging (fMRI).

PI_NAMEs: JANN, KAY  (contact);WANG, DANNY JJ

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease care;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Architecture;autosomal dominant Alzheimer's disease;Biological Markers;Brain;Clinical;clinical care;Clinical Research;cloud based;Cognitive;cohort;Computer software;connectome;Data;Dedications;Development;Disease;Disease Marker;Disease Progression;Entropy;Frequencies;Functional Magnetic Resonance Imaging;functional MRI scan;Genotype;Goals;imaging biomarker;Impaired cognition;indexing;information processing;Inherited;Ions;Late Onset Alzheimer Disease;Machine Learning;Magnetic Resonance Imaging;Measures;mild cognitive impairment;Modeling;multimodality;mutation carrier;Neurocognitive;Neurofibrillary Tangles;neuroimaging;Neuronal Injury;Neurons;neurophysiology;novel;Pathology;Pattern;Performance;Population;Positron-Emission Tomography;pre-clinical;preventive intervention;Process;public database;Public Health;Radioactive Tracers;Reporting;Rest;Sample Size;Series;Signal Transduction;Staging;Statistical Data Interpretation;tau Proteins;Techniques;Testing;Time;tool

PROJECT_TITLE: Complexity of FMRI in Alzheimer's Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: BALTZEGAR, DAVID ANDREW (contact)

PROJECT_TERMS: Address;Area;Bioinformatics;cluster computing;Communities;complement system;Computer software;Consultations;Core Facility;cost;Data;Data Analyses;data exchange;data management;Data Science;Data Storage and Retrieval;data visualization;Dedications;design;Education;Eligibility Determination;Ensure;Environment;Environmental Exposure;Environmental Health;Environmental Impact;Environmental Risk Factor;epigenomics;Evaluation;Experimental Designs;Funding;Genomics;Health;Health Sciences;Human;Human Resources;in silico;In Vitro;in vivo;Informatics;innovation;instrumentation;Integrative Medicine;interest;Knowledge;Laboratories;large datasets;Link;Management Information Systems;Maps;Measurement;member;Memory;metabolomics;Metals;Methodology;Methods;Mission;Monitor;multidisciplinary;multiple omics;novel;parallel computer;Pathway interactions;Performance;Phase;Population Study;Procedures;programs;Proteomics;Publications;Qualifying;quality assurance;Quality Control;Reaction;Reporting;Research;Research Personnel;Resources;Sampling;Schedule;Scientist;Services;small molecule;Solid;Structure;Techniques;Technology;technology platform;Toxic Environmental Substances;Training;transcriptomics;Translations;Universities;voucher;web server;web site

PROJECT_TITLE: Systems Technologies Core


NIH_SPENDING_CATS: Biotechnology;Social Determinants of Health

PI_NAMEs: HOPPIN, JANE  (contact)

PROJECT_TERMS: Adverse effects;Affect;Animal Model;Applications Grants;Biological;Canis familiaris;Cavia;Cells;Collaborations;Comparative Pathology;Consultations;cost;Dedications;Development;Domestic Animals;Endocrine system;Environment;Environmental Exposure;Environmental Health;Environmental Risk Factor;Evaluation;Family suidae;Fishes;Genetic Engineering;Genetically Modified Animals;Health;health science research;Histology;Human;human disease;in vivo;in vivo Model;Laboratories;Lesion;Link;Malignant Neoplasms;member;Microtus;Mission;model organism;Molecular;Molecular Analysis;Mus;Neurologic;Organ;Organism;Oryctolagus cuniculus;Oryziinae;Outcome;Pathologic;Pathology;Pathway interactions;Publications;Rattus;Reproduction;Scientist;Sheep;Systems Biology;Techniques;Technology Assessment;technology platform;Tissues;Toxic effect;Toxic Environmental Substances;Training;Vertebrates;Xenopus;Zebrafish

PROJECT_TITLE: Comparative Pathology Core


NIH_SPENDING_CATS: Bioengineering;Digestive Diseases;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Public health relevance In addition to its nutrient-absorption functions, gut epithelium is the site in which neural, immune, microbial and dietary factors interact. These multi-system interactions critically regulate whole-body physiology ranging from metabolism, immunity to cognition. At the foundation of these interactions are the healthy and balanced number of gut epithelial cells. As the largest exposed surfaces of the body, billions of cells are shed from the human gut epithelium every day. These lost cells are constantly replaced by intestine stem cells. Activity of intestine stem cell has to be precisely controlled or it may cause tumorigenesis. Currently, 200,000 new cases of gastrointestinal tract cancers are reported each year. Therefore, deciphering the mechanisms that regulate intestine stem cell behavior and gut homeostasis is important for understanding how gut homeostasis is maintained in normal conditions but altered in diseases.

PI_NAMEs: XIANG, YANG  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Adenosine;Adult;Biochemical;Biological;biological adaptation to stress;Biological Assay;Body Surface;cell behavior;Cell Count;Cell membrane;Cell Physiology;cell type;Cells;Chemicals;Cognition;Colorectal Cancer;Cues;Defect;Detection;Dietary Factors;Disease;Drosophila genus;Electrophysiology (science);Enterocytes;Enteroendocrine Cell;Epithelial Cells;Epithelium;Exposure to;fly;Food;Foundations;Gastrointestinal Diseases;gastrointestinal epithelium;gastrointestinal function;Gastrointestinal tract structure;Generations;Genetic;Goals;gut homeostasis;Health;Homeostasis;Human;Image;Immune;Immunity;Impairment;in vivo;innovation;Intestines;Irritants;Knock-in;Knowledge;Lipids;Liquid substance;Malignant neoplasm of gastrointestinal tract;Mammals;mechanical force;mechanical signal;Mechanics;mechanotransduction;Mediating;Membrane;Membrane Fluidity;Metabolism;microbial;Midgut;mutant;neural;Neurodegenerative Disorders;Neurons;novel;nutrient absorption;Peristalsis;Physiological;Physiology;Pilot Projects;programs;Property;Protein Isoforms;public health relevance;Purinergic P1 Receptors;Purines;Purinoceptor;receptor;Regulation;Reporting;response;Role;selective expression;sensor;sensory stimulus;Shapes;shear stress;Signal Transduction;Signaling Molecule;Site;stem cell biology;stem cell proliferation;stem cells;Stimulus;Stretching;synergism;System;Tachykinin;Testing;Time;tissue regeneration;Tissues;tool;TRP channel;TRPA channel;tumorigenesis

PROJECT_TITLE: Mechanical regulation of intestine stem cell-mediated tissue homeostasis in Drosophila

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: BINDER, ANDREW R. (contact)

PROJECT_TERMS: Attention;Awareness;Collaborations;Communication;Communities;community engagement;Community of Practice;community partners;Consult;Core Facility;dissemination strategy;Education;Environment;Environmental Exposure;Environmental Health;Environmental Impact;Environmental Risk Factor;forging;Fostering;Funding;Health;health communication;Health education;health knowledge;health literacy;Human;Infrastructure;insight;interest;Interest Group;Knowledge;Lead;Leadership;Link;literacy;Mission;North Carolina;novel;prevent;Publishing;Research;research data dissemination;Research Personnel;Resources;Scholarship;social;social media;Suggestion;symposium;Translating;Translations;vulnerable community;Vulnerable Populations;Work

PROJECT_TITLE: Community Engagement Core


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: FAYETTEVILLE

ORG_NAME: FAYETTEVILLE STATE UNIVERSITY

PHR: Relevance: The U-RISE program is designed to provide trainees the knowledge, skills, and experiences for Ph.D. degree completion and entry into the biomedical research workforce to reduce or eliminate healthcare disparities in this country.

PI_NAMEs: RAYNOR, JAMES EDWARD (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: academic preparation;Awareness;Bachelor's Degree;Benchmarking;Biology;Biomedical Research;Chemistry;cohort;college;computer science;COVID-19 pandemic;Degree program;design;Development;efficacy research;Evaluation;Event;evidence base;experience;Forensic Sciences;Funding;Future;Goals;graduate school;higher education;Institution;Intervention;Interview;Light;mathematical sciences;matriculation;Measures;meetings;Mentors;Methods;minority trainee;North Carolina;Phase;Process;Program Effectiveness;programs;Research;Research Training;Self Efficacy;Series;skills;Students;System;Talents;Training;Training Activity;Training Programs;Underrepresented Minority;underrepresented minority student;Universities;virtual

PROJECT_TITLE: U-RISE Program at Fayetteville State University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Clinical Research;Social Determinants of Health

PI_NAMEs: WANG, HONG  (contact)

PROJECT_TERMS: Address;Area;Award;base;Behavior;career;career development;Clinical;Collaborations;Communities;community partners;Core Facility;Data;Disease;Environment;Environmental Health;Environmental Impact;Environmental Risk Factor;Epigenetic Process;Extramural Activities;Faculty;Fostering;Funding;Genes;Genetic;Goals;Health;health science research;high risk;Human;innovation;Interdisciplinary Study;interest;Interest Group;Link;lung health;medical schools;member;Mentors;Mission;National Institute of Environmental Health Sciences;Neurosciences;North Carolina;Pilot Projects;Policies;Population;programs;public health research;recruit;Research;Research Personnel;Research Support;Resources;skills;Strategic Planning;success;United States National Institutes of Health;Universities

PROJECT_TITLE: Pilot Project Program


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Social perception is a fundamental feature of social communication, with impairments in this process leading to an inability to form meaningful and stable relationships, severely affecting individuals’ physical and mental well- being. Yet, how the brain perceives and transforms social cues into socially appropriate behavior remains poorly understood. This proposal will identify neuronal populations and genomic pathways in the brain that process social status cues and guide socially competent behavior enabling us to better understand the neurobiology of social perception.

PI_NAMEs: CURLEY, JAMES PATRICK (contact);TRAINOR, BRIAN C

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Address;Affect;Amygdaloid structure;Animals;autism spectrum disorder;Behavior;behavior test;Behavioral;Brain;brain cell;Brain region;Cell Nucleus;Cellular Compartment Analysis;Characteristics;Complex;Cues;Data Set;differential expression;Emotional;Environment;Exposure to;Female;Fluorescent in Situ Hybridization;Foundations;Gene Expression;Gene Expression Profile;Genetic Markers;Genetic Transcription;Genomics;Housing;Human;Hypothalamic structure;Impairment;In Situ Hybridization;Individual;innovation;Knowledge;Loneliness;male;Measures;Medial;Molecular;multidisciplinary;Mus;neural;neural patterning;Neurobiology;Neurodevelopmental Disorder;Neurons;Neuropeptide Receptor;Neurosciences;novel;Odors;Output;Oxytocin;Oxytocin Receptor;Pathway interactions;Pattern;Perception;Personal Satisfaction;Population;Primates;Process;Productivity;programs;receptor;Regulation;Research;response;Rodent;Role;Sensory;sex;sex variable;Signal Transduction;single nucleus RNA-sequencing;social;Social Behavior;Social Change;social communication;Social Discrimination;Social Dominance;Social Environment;Social Hierarchy;Social Interaction;Social Perception;social relationships;Social status;Stimulus;System;Techniques;Testing;Time;tool;Transcriptional Activation;transcriptomic profiling;Translational Repression;Translations;Vasopressin Receptor;Vasopressins;Well in self;Work

PROJECT_TITLE: Neural processing of status signals in social hierarchies

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Immunotherapy;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative Relapsed leukemia after allogeneic hematopoietic stem cell transplantation (allo-SCT) is the major obstacle for successful allo-SCT, and its response to donor lymphocyte infusion (DLI) involves reversal of T cell exhaustion. The objective of these studies is to specifically define and target the mechanisms by which exhausted T cell subsets mediate DLI efficacy and are themselves shaped by oncogenic pathways. At the same time, the proposed studies will establish a paradigm for mapping co-evolving cancer-immune interactions within the tumor microenvironment relevant for immunotherapeutic outcomes beyond DLI.

PI_NAMEs: BACHIREDDY, PAVAN  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Advisory Committees;Allogenic;antigen-specific T cells;Architecture;Automobile Driving;Behavior;Biological Models;Biology;Blood;Bone Marrow;candidate identification;career;career development;Cell Communication;Cells;Chromatin;Chronic Myeloid Leukemia;Clinical;Clonality;Communities;Computational Biology;Dana-Farber Cancer Institute;Data;design;Development Plans;Donor Lymphocyte Infusion;Environment;Epigenetic Process;epigenomics;Evolution;exhaust;exhaustion;Exhibits;exome;Functional disorder;functional genomics;Gene Expression;gene regulatory network;Genetic;Genomics;Goals;graft vs leukemia effect;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Heterogeneity;Human;Immune;Immune system;Immunology;Immunosuppression;Immunotherapeutic agent;Immunotherapy;in silico;in vivo;Infusion procedures;insight;International;leukemia;leukemia relapse;Leukemic Cell;Malignant Neoplasms;Maps;Mediating;Mentorship;Modeling;Molecular;molecular phenotype;Molecular Profiling;Mononuclear;mortality;mouse model;Mus;Mutation;neoantigens;novel;Oncogenic;Oncology;Outcome;Pathway interactions;Patients;PD-1 inhibitors;PD-1 pathway;Physicians;Population;post-transplant;progenitor;Records;Recurrent disease;Regulation;Relapse;repaired;Research;Research Personnel;Resistance;response;Role;Scientist;Shapes;single-cell RNA sequencing;stem;Stem cell transplant;Study models;System;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Time;Training;transcriptome;transcriptomics;tumor;Tumor Immunity;tumor microenvironment;Viral

PROJECT_TITLE: Elucidating Human Leukemia and T Cell Interactions within the Tumor Microenvironment

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative The use of broadly neutralizing antibodies as a therapy or potential cure for HIV is promising, but a major obstacle to testing its potential is determining in what patients it may be most beneficial. We are developing a rapid turnaround assay using a single cell viral outgrowth neutralization assay (scVONA), which obtains information about the functional viral reservoir in patients and its sensitivity to bNAbs within two weeks.

PI_NAMEs: CHEN, BENJAMIN K (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: analysis pipeline;Anti-viral Agents;Antibody Therapy;barrier to testing;Bioinformatics;Biological Assay;CD4 Lymphocyte Count;CD4 Positive T Lymphocytes;Cell Line;Cell model;Cells;Clinical;Cloning;Coculture Techniques;cohort;combinatorial;cost;Detection;Development;DNA;env Genes;Flow Cytometry;genetic analysis;genetic resistance;high throughput screening;HIV;HIV-1;Immune;Immune response;immunoregulation;In Vitro;in vivo;Individual;Infection;International;Laboratories;latent HIV reservoir;Length;Link;Maps;Measures;Mediating;Neutralization Tests;neutralizing antibody;novel;Patients;Phase;Phenotype;Property;Protocols documentation;Recording of previous events;Reporter;Resistance;resistance mutation;Resolution;RNA;RNA Splicing;Sampling;Sensitivity and Specificity;Sequence Analysis;sex;Site;Sorting;T-Cell Activation;Testing;Therapeutic Studies;Time;Titrations;Transcript;Transcriptional Activation;Viral;Viral Load result;Viral reservoir;Virus;Virus Latency

PROJECT_TITLE: Quantifying bNAb neutralization of the HIV latent reservoir


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative: Heart disease is the leading cause of morbidity and mortality in the United States and cardiomyocyte hypertrophy is a major hallmark in disease progression. Understanding of the fundamental mechanism of gene regulation at the level of protein synthesis in cardiomyocytes in normal physiology and during cardiomyocyte hypertrophy will provide novel insights for preventive and therapeutic interventions of heart disease. In this proposal, we will investigate the function and mechanism of translation control mediated by a novel double-stranded RNA element in synergy with upstream open reading frames, which is required for maintaining cardiac physiological homeostasis. These studies will provide proof-of-concept evidence to support developement of novel therapeutic targets and RNA-based modality for treating cardiac pathological hypertrophy.

PI_NAMEs: YAO, PENG  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: 5' Untranslated Regions;Animals;Antisense Oligonucleotides;aorta constriction;Biochemical;Bioinformatics;Biological;Biological Assay;Biology;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cell Culture System;Cells;Chemistry;CRISPR/Cas technology;Data Analyses;Databases;design;Development;Disease Progression;Double-Stranded RNA;Elements;Exhibits;GATA4 gene;Gene Expression Regulation;Genetic;genome editing;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Homeostasis;Human;human disease;human embryonic stem cell;Hypertrophy;Initiator Codon;innovation;insight;Intervention;Knock-in Mouse;Left;loss of function;Mediating;Modality;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;new therapeutic target;novel;novel therapeutic intervention;Open Reading Frames;Output;Pathogenicity;Pathologic;Peptides;Phenotype;Physiology;pressure;preventive intervention;Protein Biosynthesis;protein expression;Proteins;Regulation;Repression;ribosome profiling;RNA;RNA Helicase;Role;Specificity;Stress;Structure;synergism;Technology;Therapeutic Intervention;therapeutic RNA;Trans-Activators;Transcript;transcription factor;Translating;Translational Repression;Translations;United States

PROJECT_TITLE: uORF-mediated Translational Control of Cardiac Transcription Factor Expression

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: ANESTHESIOLOGY

PHR: Given the central role of mitochondrial dysfunction in Alzheimer’s disease (AD), defining the impact of AD-relevant, pathological tau species on mitochondrial/neuronal function is of critical importance. The genetic model C. elegans provides an excellent system for elucidating the impact of pathological posttranslational modifications of tau on mitochondrial biology and neuronal health as a function of age. The results of these studies have the potential of identifying unique targets for intervention to attenuate disease progression.

PI_NAMEs: JOHNSON, GAIL V. W. (contact);NEHRKE, KEITH

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Ablation;Acceleration;Acetylation;Address;Affect;Age;Age of Onset;age related;age related neurodegeneration;Aging;Alzheimer's Disease;Alzheimer's disease brain;Attenuated;Auxins;Behavioral;biological adaptation to stress;Biology;Biosensor;Buffers;Caenorhabditis elegans;Cells;Collaborations;comparative;CRISPR/Cas technology;Data;Dedications;Diet;Disease;disease model;Disease Progression;early onset;Epitopes;Exercise;Exhibits;Foundations;functional decline;Gene Modified;Genes;Genetic;Genetic Models;genetic resource;Genetic Transcription;genome resource;Health;healthy aging;Homeostasis;imaging approach;Impairment;insight;Intervention;Knowledge;Lentivirus;Measures;Mediator;Metabolic;mimetics;Mitochondria;mitochondrial dysfunction;model organism;Modeling;Molecular;Mus;mutant;Mutation;Nematoda;Neurodegenerative Disorders;neuron loss;Neuronal Dysfunction;Neurons;neurotoxicity;novel;Nuclear;optogenetics;Organelles;Output;overexpression;Oxidative Stress;Pathogenesis;Pathologic;Pathway interactions;Phenotype;Phosphorylation;Physiological;Play;Post-Translational Protein Processing;Process;Proteins;proteostasis;proteotoxicity;Quality Control;receptor;response;Role;Severities;Signal Pathway;Signal Transduction;Site;stem;Stress;Structure;System;tau aggregation;tau expression;tau function;tau mutation;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;Time;Toxic effect;Transgenic Model;Transgenic Organisms;Translating;translational potential;Ubiquitin

PROJECT_TITLE: Tau Post-Translational Modifications and Mitochondrial Quality Control

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Anxiety can emerge as early as pre-school age (4-6) and is often linked to anxiety in the parent. While we believe that this transmission is driven by both genetics and parenting behavior, we do not understand the moment-to-moment interactions that support intergenerational transmission. The current longitudinal study will examine patterns of dyadic social dynamics captured in neural and physiological synchrony and emotion modeling as the transmission mechanisms, with the potential to translate findings into dyadic interventions.

PI_NAMEs: PEREZ-EDGAR, KORALY E (contact);PERLMAN, SUSAN B

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Affect;Age;Animal Model;Anxiety;Anxiety Disorders;anxiety symptoms;Arousal;Arousal and Regulatory Systems;Attention;Behavior;Behavioral;Biological;Buffers;calcification;Caregivers;Child;Child Rearing;childhood anxiety;Climate;Cognitive;cognitive control;coping;Coupled;Coupling;Data;Development;developmental disease;Diagnosis;Diagnostic;Distress;dyadic interaction;early childhood;Electroencephalography;Emotional;Emotions;Ensure;Environment;Event;experience;Exposure to;Family dynamics;Family Relationship;Fathers;fetal programming;Fright;functional near infrared spectroscopy;Genetic;Genetic Load;human model;in vivo;Individual;Informal Social Control;intergenerational;Intervention;Link;Literature;Longitudinal Studies;Measures;Mediating;middle childhood;Modeling;Mothers;multimodality;Negative Valence;neural;novel;Nursery Schools;Outcome;Parents;Pathway interactions;Pattern;peer;Physiological;Pregnancy;Process;Protocols documentation;Psychopathology;Psychophysiology;psychosocial;Questionnaires;recruit;Regulation;Research Domain Criteria;response;Risk;Sampling;School-Age Population;Series;sex;Shapes;Signal Transduction;social;Social Environment;Speech;Stress;Symptoms;System;Temperament;Time;Translating;transmission process;Trier Social Stress Test;Variant;visual tracking;Withdrawal

PROJECT_TITLE: Parent-to-child anxiety transmission in early childhood: Capturing in-the-moment mechanisms through emotion modeling and biological synchrony

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE  The central amygdala (CeA) is a subnucleus of the amygdala that encodes ‘valence’, defined as the subjective value assigned to sensory stimuli that impacts consequential behavior. It remains unclear whether different valences (positive or negative) are processed in the same or distinct cells, I hypothesize that the corticotropin-releasing factor (CRF)-expressing neurons in the CeA process both valances but in a state- dependent manner. My proposed research will determine whether the order of two experiences holding different valences results in a biased state dependence that favors valence coding by CeA-CRF towards the initial experience.

PI_NAMEs: KONG, MI-SEON  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Address;Affect;Affective;Amygdaloid structure;Anxiety;Appetitive Behavior;Behavior;Behavioral;behavioral outcome;behavioral response;Brain;Brain region;cell type;Cells;Code;Corticotropin-Releasing Hormone;Decision Making;Dependence;designer receptors exclusively activated by designer drugs;Desire for food;Development;directed attention;Emotional;experience;experimental study;Fright;Genetic;Genetic Techniques;Imaging Techniques;in vivo calcium imaging;Incentives;Infusion procedures;innovation;insight;Learning;Light;Link;Mediating;Mediator;Molecular;motivated behavior;Motivation;mouse genetics;Negative Valence;neural circuit;neuronal circuitry;Neurons;Nucleus Accumbens;optogenetics;Output;Physiological;Play;Positive Valence;Process;Regulation;Reporting;Research;response;Rewards;Role;sensory stimulus;Stimulus;Structure;System;Techniques;Testing;Tetanus Toxin;Thalamic structure;tool;Training

PROJECT_TITLE: Orchestrating state-dependent modulation of motivations in central amygdala CRF neurons