NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: NOTRE DAME

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project narrative Mechanobiology has emerged as a new frontier in T cell biology. However, the mechanisms are poorly understood, which impact our collective ability to understand, predict, and control T cell immune recognition. Here, the mechanisms of T cell mechanobiology will be elucidated and used to better understand and control T cell recognition, with wide implications for understanding and manipulating the immune system in health and disease.

PI_NAMEs: BAKER, BRIAN M (contact);EVAVOLD, BRIAN D

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Accounting;Address;Affect;Affinity;alpha-beta T-Cell Receptor;Antigens;Automobile Driving;Behavior;Binding;Biological Process;Biology;Cartoons;cell behavior;Cell Communication;Cell Physiology;Cellular biology;Cellular Immunity;Collaborations;Complex;computer framework;Computer Simulation;design;Disease;Education;Engineering;Epitopes;foot;frontier;Goals;Health;Immune;Immune system;immunogenicity;Immunologics;Immunologist;Immunotherapy;improved;infancy;Infection;interest;Kinetics;Knowledge;lens;Libraries;Ligands;Lymphocytic choriomeningitis virus;Measurement;mechanical force;Membrane;Mus;Mutation;Nature;Output;Peptide/MHC Complex;Peptides;Physics;predictive modeling;Productivity;Property;Proteins;Publishing;receptor;response;Science;screening;Signal Transduction;simulation;Specificity;Structure;success;T cell response;T-Cell Immunologic Specificity;T-Lymphocyte;Testing;theories;Thymus Gland;Tumor Antigens;Variant;Viral;Viral Antigens;Virus Diseases;Work;Writing

PROJECT_TITLE: Mechanisms and manipulation of force dependent behavior in T cell biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-F(90)]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: BRONX

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Narrative Aging has been known to be a common risk factor to the large group of age-related disorders, including Alzheimer’s disease and related dementias (AD/ADRD). However, the mechanisms by which aging increases vulnerability to the toxicity of proteins related with AD remain unknown. This Program Project aims at answering this question building in the multidisciplinary team assembled (with expertise in biology of aging, neurodegeneration, lysosomal biology, metabolism, nutrient sensing, immunology, stem cells, medicinal chemistry, drug development and advance imaging procedures), the programmatic approach and the series of tools, resources and models developed by the team in previous periods. We will analyze if the age- dependent changes in autophagy are behind the aggravating effect of aging in AD-related proteotoxicity and test if preventing autophagy deterioration with genetical, chemical and dietary intervention is beneficial in this context. Our studies may ultimately lead to fundamental insights in understanding, treating or preventing AD and other common diseases related with loss of proteostasis that affect our elders.

PI_NAMEs: CUERVO, ANA MARIA (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Acceleration;Adipose tissue;Advisory Committees;Affect;Age;age effect;age group;age related;age related changes;age-related disease;Aging;aging process;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Animal Model;anti aging;Attenuated;Autophagocytosis;biological adaptation to stress;Biology;Biology of Aging;Biometry;Brain;Cardiovascular system;Cell Physiology;Cellular biology;Chemicals;Chronic;Chronic Disease;Communication;comorbidity;Data Analyses;data integration;Dendritic Cells;detection of nutrient;Deterioration;Diabetes Mellitus;dietary;Dietary Intervention;Disease;drug development;Elderly;Experimental Models;Faculty;Genetic;Geroscience;glucose metabolism;Goals;group cooperation;healthspan;Hematopoiesis;Hematopoietic System;Image;Imaging Techniques;Immune;Immune response;Immune system;Immunology;Impairment;improved;in vivo imaging;Incidence;Inflammation;Inflammatory;innovation;insight;Institution;Intervention;Life;lipid metabolism;Liver;Lymph;Lymphatic System;Mammals;Mediating;member;Metabolic;Metabolism;Modeling;Molecular Chaperones;mouse model;multidisciplinary;Nerve Degeneration;novel;Organ;Organism;Pancreas;Pathology;Pathway interactions;Patients;Peripheral;Pharmaceutical Chemistry;Play;Positioning Attribute;pre-clinical;prevent;Process;programs;Proteins;proteostasis;proteostasis loss;proteotoxicity;Quality Control;Research Activity;Resolution;Resources;response;Risk Factors;Role;Sampling;Series;Skeletal Muscle;stem cell biology;stem cell function;stem cells;Stress;System;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic;Tissues;tool;Toxic effect;Transcend;Transference

PROJECT_TITLE: Autophagy in aging: testing geroscience in Alzheimer's disease


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Data Science;Drug Abuse (NIDA only);Genetics;Human Genome;Patient Safety;Precision Medicine;Substance Misuse

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Drug response is inherited in much the same way as other traits like height, hair color, and the risk for some diseases. Pharmacogenomics studies how human genetic (DNA) variation influences the response to drugs. The PharmGKB resource aims to catalog all the human variation that impacts drug response, so that individual genetic data can be used to choose drugs for the individual that are more likely to work, and less likely to cause side effects.

PI_NAMEs: KLEIN, TERI ELLEN (contact);WHIRL-CARRILLO, MICHELLE

PROGRAM_OFFICER_NAME: MINEAR, MOLLIE A

PROJECT_TERMS: Academia;Adverse effects;Adverse event;Area;Basic Science;Binding;Catalogs;Clinic;Clinical;clinical care;clinical implementation;Clinical Research;clinically significant;ClinVar;Collaborations;Communities;Complement;computer infrastructure;Computer software;Computing Methodologies;Data;data integration;data interoperability;data sharing;Dedications;Development;Devices;Discipline;Disease;DNA;Dose;drug efficacy;Drug Kinetics;Drug Prescriptions;Environment;experience;FAIR principles;flexibility;Funding;Generations;Genes;Genetic;Genetic study;Genetic Variation;Genome;genome resource;Genomic medicine;Genomics;Guidelines;Hair Color;Health;Height;Human;Human Genetics;improved;Individual;information organization;Inherited;International;Intervention;Knowledge;Knowledge acquisition;knowledge integration;knowledgebase;Label;Laboratories;Literature;Measures;Medical;Medicine;Methods;Mission;Molecular;Molecular Biology;National Human Genome Research Institute;novel;outreach program;Pathway interactions;Patients;Pediatrics;Persons;Pharmaceutical Preparations;Pharmacodynamics;Pharmacogenetics;Pharmacogenomics;pharmacokinetics and pharmacodynamics;Pharmacology;Phenotype;Physiological;Positioning Attribute;precision medicine;Procedures;programs;public repository;Research;Research Personnel;Resources;response;Rest;Risk;Role;Rural;Safety;side effect;Source;standard of care;success;synergism;Testing;Therapeutic;Time;tool;Toxic effect;trait;Translational Research;United States National Institutes of Health;Variant;Vision;web page;web site;Work

PROJECT_TITLE: PharmGKB

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)S]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative

PHR: Narrative  This core is essential for coordinated functioning and integration of the projects and cores into a cohesive program. It allows for faster and more efficient progress toward the elucidation of the molecular basis for the functional decline of organs and systems with age and the contribution of this deterioration to increased susceptibility to disease. The core has a key sub-component responsible for data integration and interpretation and that will also serve to monitor rigor on experimental design and data analysis.

PROJECT_TERMS: Administrative Personnel;Advisory Committees;Age;age-related disease;Aging;Alzheimer's Disease;Animal Experimentation;Animal Model;Arbitration;Area;Autophagocytosis;Awareness;biocomputing;Biology of Aging;Biometry;Budgets;central database;Communication;Communities;Computer software;Continuing Education;Data;Data Analyses;Data Collection;data curation;data integration;data management;Data Storage and Retrieval;Database Management Systems;Dedications;Deterioration;Disease;Disputes;Educational process of instructing;Educational workshop;Evaluation;Experimental Designs;Formulation;functional decline;Funding;Future;Geroscience;Goals;Grant;Human Resources;Individual;Institution;interest;investigator training;Joints;large datasets;Maintenance;material transfer agreement;meetings;member;Mentors;Mission;Molecular;Monitor;Online Systems;Organ;Output;power analysis;Predisposition;Procedures;Program Research Project Grants;programs;Progress Reports;proteostasis;proteotoxicity;Protocols documentation;Quality Control;Reagent;Reproducibility;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Resolution;Resources;Sampling;Schools;Scientist;Secure;Services;Standardization;Statistical Data Interpretation;Statistical Methods;symposium;System;Techniques;Testing;Text;tool;Training;training opportunity;Training Programs

PROJECT_TITLE: Core A - AdministrativeCore/Biocomputational Unit


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: AUGUSTA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative  We discovered that the natural product EnnA is a novel Heat Shock Protein 90 (Hsp90) inhibitor that exhibits a powerful antitumor activity through a novel mechanism involving dual effects: cancer cell toxicity that increases its immunogenicity, and modulation of the tumor microenvironment that reduces immunotolerance. Mechanistically, Enniatin A binds to the middle domain of Hsp90 and reduces the protein level of several oncogenic proteins and the programmed cell death ligand-1 (PDL-1), a key mediator of tumor-induced immune tolerance. Enniatin A is a promising compound combining to eradicate cancer through inactivation of the Hsp90 pathway.

PI_NAMEs: CHADLI, AHMED  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: 4T1;Achievement;Affect;Amino Acids;anti-CTLA4;anti-tumor agent;Antigen-Presenting Cells;Antigens;antitumor effect;Antitumor Response;Apoptotic;Autophagocytosis;Binding;Binding Sites;Biochemical;Breast Cancer Model;Breast Cancer Patient;Breast Cancer therapy;cancer cell;Cancer Patient;cancer therapy;cancer type;carcinogenesis;CD28 gene;CD8-Positive T-Lymphocytes;Cell Death;cell mediated immune response;Cell membrane;Cell surface;Cells;chemotherapy;Client;Clinical;clinical efficacy;Combination immunotherapy;combinatorial;Cross Presentation;CTLA4 blockade;CTLA4 gene;Cyclic Peptides;cytotoxic;Data;design;dimer;Docking;dosage;Drug Kinetics;ERBB2 gene;Event;Exhibits;experience;Generations;Goals;Head and Neck Cancer;Heat-Shock Proteins 90;Heat-Shock Response;HSP 90 inhibition;Immune;immune cell infiltrate;immune checkpoint blockade;Immune response;Immune system;Immune Tolerance;Immuno-Chemotherapy;immunogenic;immunogenic cell death;immunogenicity;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;Infiltration;inhibitor;innovation;insight;interest;Ligands;Malignant Breast Neoplasm;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Mediator;Melanoma;Membrane;Metastatic Melanoma;Minority;Modeling;Molecular;Molecular Chaperones;mouse model;Mus;Mutate;Mutation;Natural Products;Neoplasm Transplantation;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Oncogenic;Outcome;overexpression;Pathway interactions;patient response;Pharmaceutical Preparations;Play;Population;preclinical development;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;protein expression;Proteins;receptor;recruit;Regimen;Renal Carcinoma;Role;side effect;Site;small molecule;Solid Neoplasm;stem;success;Surface;Surface Plasmon Resonance;System;T cell infiltration;T-Cell Activation;T-Lymphocyte;targeted agent;Testing;Therapeutic;Therapeutic Effect;therapeutic effectiveness;Toxic effect;Translating;Transplantation;Treatment Efficacy;treatment response;triple-negative invasive breast carcinoma;tumor;tumor eradication;tumor growth;tumor microenvironment;Tumor Promotion;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: A novel therapeutic strategy to eradicate breast cancer through Hsp90 inhibition and reduced immune tolerance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: Narrative   This core is essential for all the four projects in this program as it allows the study of proteostasis in the whole  tissue and at the cellular level by using different imaging modalities. The core has a component of imaging  service to provide support to routine imaging procedures and sample preparation and a key component of  innovation that will develop new imaging procedures on superresolution and light-sheet microscopy for use in  the study of proteostasis in aging. The core provides support for interpretation of imaging data as well as monitors  rigor on experimental design and image data analysis.

PI_NAMEs: BRAVO-CORDERO, JOSE JAVIER  (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Animals;Antibodies;Area;Autophagocytosis;Brain;Cell model;Characteristics;Communities;Computer software;Confocal Microscopy;Core Facility;cost;Cost efficiency;Data;Data Analyses;data integration;Databases;Dedications;Development;Disease;Dyes;Electron Microscopy;Equipment;Experimental Designs;Fluorescence;Funding;future implementation;Geroscience;Goals;high resolution imaging;Image;Image Analysis;imaging capabilities;imaging modality;imaging platform;Imaging Techniques;Imaging technology;Immunofluorescence Immunologic;In Vitro;in vivo;in vivo imaging;Individual;innovation;Institution;instrumentation;interest;intravital imaging;intravital microscopy;Light;live cell imaging;Liver;lymph nodes;member;Methods;Microscopy;Molecular;molecular dynamics;Monitor;mouse model;Mus;nanoscale;new technology;Operative Surgical Procedures;Organ;Organelles;Pancreas;Peripheral;Physiological;Preparation;Procedures;programs;proteostasis;proteotoxicity;Protocols documentation;Quality Control;Reagent;Reporter;Research Personnel;Resolution;Resources;routine imaging;Sampling;Schools;Services;single molecule;spatiotemporal;Specimen;Standardization;superresolution imaging;superresolution microscopy;Techniques;Technology;Testing;Text;Therapeutic;Time;Tissues;tool;Training;Translations;two photon microscopy;two-photon;ultra high resolution

PROJECT_TITLE: Core B - Advance Imaging Core


ADMINISTERING_IC: TR

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Precision Medicine

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY

PHR: Project Narrative-Overall AIMINGS Center The vision of this proposed Artificial Intelligence, Modeling, and Informatics, for Nutrition Guidance and Systems (AIMINGS) Center is to implement computational and data science approaches and tools to advance nutrition for precision health in a way that accounts for the complex systems involved. Such approaches and tools that help better understand and address the systems both within individuals and surrounding individuals could not only transform nutritional research and guidance, but also do so with other areas of health.

PI_NAMEs: LEE, BRUCE Y (contact)

PROJECT_TERMS: Accounting;Address;Algorithms;All of Us Research Program;Architecture;Area;Artificial Intelligence;Behavioral;built environment;clinical application;cloud based;Complex;Computational Science;computing resources;contextual factors;Data;data imputation;Data Science;Data Set;Department of Defense;Diet;Dietary Practices;Economics;Face;flexibility;Food Patterns;Funding;Genes;Genetic;Goals;Health;Human Resources;Individual;Individual Differences;individual response;Informatics;Information Systems;insight;Knowledge;Laboratories;Learning;Metabolism;Methods;microbiome;Modeling;novel strategies;nutrition;Nutritional;operation;Pathway interactions;Persons;Physiological;Precision Health;precision nutrition;prediction algorithm;preservation;programs;Proteins;Public Health;Research;Resources;response;Skin;social;Structure;System;tool;tool development;United States National Institutes of Health;virtual;virtual human;virtual laboratory;Vision

PROJECT_TITLE: Artificial Intelligence, Modeling, and Informatics for Nutrition Guidance  and  Systems (AIMINGS) Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-A(90)S]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Genetics;Inflammatory Bowel Disease

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Dysregulated mitochondrial pathways have been increasingly implicated in inflammatory bowel disease (IBD), with the major focus being in the context of epithelial cells. We have observed that a number of IBD- associated genes regulate mitochondrial functions, which in turn, modulate key responses across a range of pattern recognition receptors (PRR) in macrophages. We will define mechanisms for mitochondrial contributions to PRR-initiated outcomes in human macrophages, determine roles for fine-tuning these outcomes in vivo in intestinal inflammation and infection, and establish how these mitochondrial functions are modulated by IBD-associated genetic variants and in intestinal tissues.

PI_NAMEs: ABRAHAM, CLARA  (contact)

PROGRAM_OFFICER_NAME: PERRIN, PETER J

PROJECT_TERMS: antimicrobial;Binding;Cells;Colitis;Communication;Cyclic GMP;cytokine;Data;Endoplasmic Reticulum;endoplasmic reticulum stress;enteric infection;enteric pathogen;Epithelial Cells;Foundations;Genes;genetic variant;Glycolysis;gut inflammation;Homeostasis;Human;human disease;Immune;Immune response;Immunity;Impairment;improved outcome;in vivo;Inflammatory Bowel Diseases;inflammatory modulation;Innate Immune Response;insight;Intestines;Laccase;Ligands;loss of function;Macrophage;Mediating;mesenteric lymph node;Metabolic Pathway;Microbe;microbial products;Mitochondria;Mitochondrial DNA;monocyte;Mus;Natural Immunity;Nucleotides;Outcome;Pathway interactions;Patients;Pattern recognition receptor;Permeability;Play;Predisposition;Proteins;Reactive Oxygen Species;Regulation;Respiratory Chain;response;Risk;risk variant;Role;Sodium Dextran Sulfate;Stimulator of Interferon Genes;Testing;therapeutic target;Tissues;Variant

PROJECT_TITLE: Mitochondrial Mechanisms Promoting Innate and Intestinal Immunity

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PHR: All four Projects require the use of similar age-controlled autophagy and CAN proteotoxicity associated with Alzheimer’s disease mouse models, but focus on different tissues. Centralizing the procedures involving animals in the Core: 1) maximizes animal use; 2) offers uniformity across the different projects; and 3) allows integration of the information obtained from different systems by the different projects. The interventions performed by the core to modulate autophagy may help set the basis for future anti-aging interventions.

PI_NAMEs: MACIAN, FERNANDO  (contact)

PROJECT_TERMS: Address;Affect;Age;age related changes;Aging;aging gene;aging process;Alzheimer's Disease;Alzheimer's disease model;animal care;animal colony;animal data;Animal Diseases;animal facility;Animal Model;Animal Technicians;Animals;anti aging;Area;Autophagocytosis;behavior test;Biology of Aging;Brain;Breeding;Cellular biology;Chemicals;Consultations;Cost efficiency;Data;Databases;design;Diet;Disease;Disease Progression;Dissection;Equilibrium;experimental study;functional restoration;Future;Gene Modified;Genetic;Genetic Models;Genetically Modified Animals;Genotype;Geroscience;Goals;Health;healthspan;Human Resources;improved;in vivo;Individual;interest;Intervention;Intranet;Laboratories;life span;Link;Maintenance;member;model design;Modeling;Monitor;mouse model;Mus;old mice;Online Systems;Onset of illness;Organ;Peripheral;pharmacologic;prevent;Procedures;programs;proteostasis;proteotoxicity;Regulation;Reporter;Reporting;Research;Research Personnel;Resources;Role;Scheme;Schools;Series;Services;System;Testing;Text;Therapeutic;Tissue Banks;Tissue Sample;Tissues;Transgenic Animals;Transgenic Mice;Veterinarians;Weaning

PROJECT_TITLE: Core C - Proteostasis Animal Models Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: RELEVANCE (See instructions):  In this grant we will illuminate the molecular details responsible for LSD's actions at the molecular level.  We will combine structural studies of psychedelic receptors complexed with LSD and related drugs. We  will also interrogate the role of specific differences between rodent and human receptors as well as  transcriptional changes downstream of psychedelic drug actions.

PI_NAMEs: ROTH, BRYAN L. (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Anxiety;Automobile Driving;Biochemical;Biogenic Amine Receptors;Biogenic Amines;ChIP-seq;Chromatin;Complex;Cryoelectron Microscopy;Disease;Dopamine Receptor;drug action;Drug Interactions;drug of abuse;experimental study;Family;Future;G-Protein-Coupled Receptors;Genetic Polymorphism;Genetic Transcription;Goals;Grant;Hallucinogens;HTR2A gene;Human;In Vitro;in vivo;Individual;insight;Instruction;interest;Lysergic Acid Diethylamide;Mediating;Mental Depression;Mescaline;Molecular;mouse model;Mus;N,N-Dimethyltryptamine;Neurons;Pharmaceutical Preparations;Pharmacology;Phase II Clinical Trials;preclinical study;programs;psilocin;Psilocybin;Psychoses;Public Health;Publications;Rattus;receptor;Research;Rodent;Role;serotonin receptor;Serotonin Receptor 5-HT2A;side effect;structural determinants;Structure;Technology;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Mechanistic insights into LSD actions at 5-HT2A serotonin receptors

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: Narrative This core will provide novel chemical compounds as modulators of a variety of autophagy pathways and chemical tools to investigate the relationship of autophagy modulation in Alzheimer’s disease onset and progression. The core will also aim to develop first-in-class targeted small molecules for autophagy pathways to investigate therapeutic effects in Alzheimer’s disease and Alzheimer’s disease-related dementias.

PI_NAMEs: GAVATHIOTIS, EVRIPIDIS  (contact)

PROJECT_TERMS: age-related disease;Aging;Agonist;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;assay development;Autophagocytosis;Biological;Biological Assay;Biological Availability;Biology;Biology of Aging;Brain;brain tissue;cell type;chemical synthesis;Chemicals;Clinical Drug Development;Communities;computer studies;Dedications;design;Development;Disease Progression;Drug Design;Drug Kinetics;effective intervention;effective therapy;Endosomes;Evaluation;experimental study;Formulation;Future;Geroscience;Goals;Immune system;improved;in vivo;Individual;innovation;insight;instrumentation;interest;Laboratories;Lead;lead optimization;Mediating;Metabolism;Mitochondria;Modeling;Molecular Chaperones;Mus;new therapeutic target;novel;Onset of illness;Oral;Organ;Pathology;Pathway interactions;Peripheral;Permeability;Pharmaceutical Chemistry;Pharmacodynamics;pharmacologic;pre-clinical;prevent;Procedures;Process;Production;programs;Property;Protocols documentation;Reagent;Research Personnel;Research Project Grants;Resources;Respiration;retinoic acid receptor alpha;Schools;screening;Services;small molecule;small molecule libraries;Structure-Activity Relationship;Technology;Testing;Text;Therapeutic;Therapeutic Effect;Tissues;tool;Treatment Efficacy;Validation;Work

PROJECT_TITLE: Core D - Chemical Biology and Therapeutics Innovation Core


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation

ORG_CITY: ATHENS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Project Narrative Large scale, traumatic orthopedic injuries can leave individuals with lifelong limitations in daily function. Some injuries, such as volumetric muscle loss injuries, are particularly challenging and currently guidelines for treatment of the muscle remain elusive. Our work seeks to understand if the local muscle environment and metabolism is limiting to adaption during various treatment and rehabilitation approaches.

PI_NAMEs: CALL, JARROD A (contact);GREISING, SARAH M

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Activities of Daily Living;Acute;Address;Amputation;Axotomy;Biomedical Technology;Bypass;Chemicals;Chronic;Clinic;Clinical;clinical care;comorbidity;Coupled;Cues;daily functioning;Denervation;Effectiveness;Environment;evidence base;Exercise;exercise training;Failure;Fatty acid glycerol esters;Foundations;functional disability;Functional disorder;Functional impairment;functional improvement;functional outcomes;functional restoration;Guidelines;Impairment;improved;Individual;injured;Injury;Knowledge;limb injury;Mechanics;Medical Care Costs;Metabolic;Metabolic syndrome;Metabolism;Mitochondria;mitochondrial dysfunction;Mobility decline;Modality;Modeling;Motor;Motor Neurons;Movement;Muscle;Muscle Fibers;Muscle function;muscle grafts;muscle physiology;Muscular Dystrophies;Myopathy;Natural regeneration;nerve supply;neuromuscular;Neuromuscular Junction;Orthopedics;Outcome;Passive Range of Motion function;Pathologic;Pathology;patient population;Patients;Physical activity;Physical Medicine;Physiological;Physiology;Population;presynaptic;Property;Publishing;Recovery of Function;recruit;regeneration potential;regenerative;Regenerative capacity;Regenerative Medicine;regenerative rehabilitation;Rehabilitation Outcome;rehabilitation strategy;Rehabilitation therapy;repaired;Research;response;sarcopenia;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle plasticity;skeletal muscle wasting;soft tissue;Source;standard of care;Technology;Testing;Tissues;treatment guidelines;two photon microscopy;volumetric muscle loss;Work

PROJECT_TITLE: Pathological Foundations of Skeletal Muscle After Volumetric Muscle Loss and Targets For Rehabilitation

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Cancer;Data Science;Dental, Oral, and Craniofacial Disease;Networking and Information Technology R&D (NITRD);Orphan Drug;Patient Safety;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: Chicago

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Cancers that depend on the spatial location of the disease affect all ethnicities, and are diagnosed each year in large numbers in the United States, leading to large, rich repositories of patient data. This project develops a longitudinal decision support tool to assist clinicians in selecting treatments that balance survival and side-effects responses to cancer therapy. The project will lead to better insights into the biological and therapeutic factors related to cancer survival and toxicity, allowing personalization of care at the individual level.

PI_NAMEs: CANAHUATE, GUADALUPE ;FULLER, CLIFTON DAVID;MARAI, GEORGETA-ELISABETA  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Accounting;Address;Affect;Age;age group;American Joint Committee on Cancer;Anatomy;Big Data;Biological;Biomedical Computing;Biomedical Engineering;Cancer Center;cancer diagnosis;cancer survival;cancer therapy;Characteristics;chemotherapy;Chemotherapy and/or radiation;Chronic;Clinic;Clinical;clinical care;clinical decision support;Clinical Management;Clinical Research;cohort;Complex;Computer Models;computer science;computerized tools;Computing Methodologies;Country;Data;data repository;Data Set;Decision Support Model;Decision Support Systems;Development;Diabetes Mellitus;Diagnosis;Disease;diverse data;Dose;Epidemic;Equilibrium;Ethnic Origin;Ethnic Population;Extramural Activities;Funding;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;high dimensionality;Hybrids;Image;improved;in silico;Individual;individual patient;individualized medicine;innovation;insight;Learning;Left;Location;Malignant neoplasm of brain;Malignant neoplasm of lung;Malignant Neoplasms;Mental disorders;Methodology;Methods;Modeling;Modification;Morbidity - disease rate;mortality;Nausea;novel;nutrition;Oncologist;Operative Surgical Procedures;optimal treatments;Organ;Outcome;outcome prediction;Patient Outcomes Assessments;patient stratification;Patients;personalized care;personalized medicine;predictive modeling;Probability;Process;prospective;prototype;Psychological reinforcement;Public Health;Quality of life;Radiation Dose Unit;Radiation therapy;Radiation Tolerance;Reporting;repository;response;Risk;risk prediction;risk prediction model;Selection for Treatments;serial imaging;side effect;Staging;standard of care;Substance abuse problem;support tools;survival outcome;symptom cluster;Therapeutic;Therapeutic Intervention;Time;Toxic effect;training data;Treatment outcome;treatment planning;treatment response;treatment strategy;Treatment-related toxicity;tumor;United States;Update;Validation;Xerostomia

PROJECT_TITLE: Longitudinal Spatial-Nonspatial Decision Support for Competing Outcomes in Head and Neck Cancer Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-E(09)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

PHR: Narrative Although it is well accepted that aging is a risk factor for the so call age-related disorders such as for example Alzheimer’s disease and related dementias, the mechanism(s) by which aging increases vulnerability to those disorders and whether interventions to slow down aging will be protective against age-related disorders has not been fully explored. This project investigates the impact of aging of one of the mechanisms used by cells as defense against intracellular toxicity and damage on the onset and progression of a highly prevalent disease among our elders, Alzheimer’s disease. We will use the plethora of molecular information on these surveillance mechanisms obtained in our previous studies to boost their function in old organisms with the goal of prevent or delay onset of neurodegeneration.

PROJECT_TERMS: Acceleration;acquired immunity;Adipose tissue;Affect;Age;age effect;age related changes;age-related disease;Aging;aging brain;aging related disease;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Animal Model;Animals;Attenuated;Autophagocytosis;base;Biological Aging;Biometry;Brain;cell growth regulation;Cell Physiology;Cells;Central Nervous System;Chemicals;Collaborations;comorbidity;Compensation;Dementia;Disease;Disease Progression;drug development;effective intervention;Elderly;Endosomes;Enhancers;Failure;Funding;Future;Genetic;Genetic Enhancement;Genome;Geroscience;Goals;hallmarks of aging;Hand;Hematopoietic System;Image;Imaging technology;Immune system;in vivo;Incidence;Intervention;Knowledge;Liver;loss of function;Maintenance;Mediating;Metabolic;Metabolism;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;mouse model;Mus;Natural Immunity;Nerve Degeneration;Neurons;novel;old mice;Onset of illness;Organ;Organism;Pathway interactions;Patients;Peripheral;Pharmacotherapy;Physiological;prevent;Prevention;Process;programs;Proteins;proteostasis;proteostasis loss;proteotoxicity;prototype;Public Health;Quality Control;response;Risk Factors;small molecule;Stress;System;tau mutation;tau Proteins;Tauopathies;Technology;Testing;Therapeutic;Time;tissue degeneration;Tissues;tool;Toxic effect;Transgenic Mice;Translations;Up-Regulation;Work

PROJECT_TITLE: Proj 1 - Interplay between peripheral autophagy and AD in aging


NIH_SPENDING_CATS: Cancer;Cervical Cancer;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: HERSHEY

ORG_DEPT: PATHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Narrative The work proposed here will develop the co-infection model system necessary to directly examine the basic premise of our hypothesis that BV bacteria promote HPV persistence and tumor progression, and contraceptive promotes HPV cancer development via altering vaginal microbiome. This is the first study to characterize, and to examine the impact of BV bacteria, hormonal contraceptive on papillomavirus associated cancer using natural papillomavirus infection model.

PI_NAMEs: GILBERT, NICOLE MARIE;HU, JIAFEN  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acceleration;aged;Anti-Bacterial Agents;Atypia;Automobile Driving;Bacteria;Bacterial Vaginosis;Biochemical;Biological;Biological Assay;Biological Models;Cancer Etiology;cancer invasiveness;carcinogenesis;Cervarix;Cervical dysplasia;Cervix Neoplasms;Cessation of life;Clinical Management;co-infection;cofactor;Contraceptive Agents;Contraceptive Usage;curative treatments;cytokine;Cytology;Data;Development;Diagnostic;Disease Progression;DNA;Dysplasia;Epidemiology;Epithelial Cells;Epithelium;Estradiol;Evaluation;Female;Future;Gardasil;Gardnerella;Gardnerella vaginalis;genital infection;Gonadal Steroid Hormones;Harvest;Histologic;hormonal contraception;Hormones;Human;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune response;Impairment;Incidence;Infection;Inflammatory Response;insight;Intervention;intraepithelial;Kinetics;Lactobacillus;Lavage;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medroxyprogesterone;Medroxyprogesterone 17-Acetate;metagenomic sequencing;microbial;microbiome;microbiome components;Modeling;Molecular;Monitor;mouse model;Mucous body substance;Mus;Neoplasms;novel;novel diagnostics;novel therapeutic intervention;Observational Study;Organism;Pap smear;Papillomavirus;Papillomavirus Infections;Patients;Pre-Clinical Model;Predisposition;Prevotella;Process;prophylactic;Proteins;Publishing;Reporting;reproductive;reproductive tract;Ribosomal RNA;Risk;RNA;Role;Sampling;sex;Sexually Transmitted Diseases;Squamous cell carcinoma;Testing;therapy development;Time;Tissues;tool;translational study;tumor progression;Vaccines;Vagina;Vaginal Human Papilloma Virus;vaginal microbiome;Viral;viral DNA;Virus Diseases;Woman;Work

PROJECT_TITLE: A co-infection model for papillomavirus associated infections and cancers

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Immunotherapy;Lymphatic Research;Neurodegenerative;Neurosciences

PHR: Narrative The goal of this project is to analyze the very early protein’s modifications that precede the protein aggregates typical of Alzheimer ’s disease. Additionally, a second goal is to analyze the role of the lymphatic fluid in transporting the brain-associated molecular signature to the cervical lymph-nodes in physiological and pathological conditions.

PI_NAMEs: SANTAMBROGIO, LAURA  (contact)

PROJECT_TERMS: Active Immunotherapy;adaptive immune response;Address;Affect;age related;Aging;aging brain;aging process;aging related;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-Protein;Antigens;Autoantigens;Autophagocytosis;Awareness;Biochemical;biophysical analysis;Blood;Brain;Brain Drains;brain parenchyma;Brain Pathology;Cells;Cellular biology;Cervical;Cervical lymph node group;Clinical Trials;Communication;Complex;Data;Degenerative Disorder;Dendritic Cells;Development;Disease;Endosomes;Event;Geroscience;Goals;humanized mouse;Immune;Immune response;Immune system;Immune System Diseases;Immunologic Surveillance;Immunotherapy;Inflammation;Inflammatory;Lymph;lymphatic circulation;Lymphatic System;Maps;Mediating;Modification;Molecular;Molecular Profiling;mouse model;Mus;Nerve Degeneration;old mice;Organ;Organelles;Oxidation-Reduction;Passive Immunotherapy;Pathologic;Pathology;Pathway interactions;Peptide Mapping;Peptides;Peripheral;Phase;Phenotype;Physiological;Play;Post Translational Modification Analysis;Post-Translational Protein Processing;Process;protein aggregation;Proteins;Proteome;Proteomics;proteostasis;proteostasis loss;Role;Stains;synthetic peptide;System;T cell response;T-Lymphocyte;Testing;Therapeutic;Trust;Vaccination;Weather

PROJECT_TITLE: Proj 2 - Lymphatic system as a conduit for age-related defective proteostasis in AD


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Adolescent Sexual Activity;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Teenage Pregnancy;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Alcohol use and sexual risk behaviors are significant public health concerns, especially among young women with sexual victimization histories. The proposed study seeks to advance our knowledge of specialized intervention strategies to reduce alcohol-related sexual risk behavior in young women impacted by sexual victimization. Development and testing of a novel technology-based intervention to address the unique needs of this high-risk and underserved group is crucial to reducing alcohol-related sexual risk and consequences.

PI_NAMEs: BLAYNEY, JESSICA ALLISON (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: acceptability and feasibility;Address;Age;Alcohol consumption;alcohol content;alcohol intervention;alcohol research;Alcohols;Award;Baseline Surveys;Behavior;Behavior Therapy;Child Sexual Abuse;Communication;comparison control;comparison intervention;condoms;coping;Cues;Data;Development;Distress;drinking;Dropout;Educational workshop;emotion regulation;Enhancement Technology;experience;Exposure to;Faculty;Feedback;follow-up;Frequencies;Funding;Goals;high risk;HIV;improved;Individual;innovation;Intervention;intervention delivery;intervention effect;intervention refinement;Interview;intimate partner violence;Knowledge;Mediating;Mediation;Mentors;Methods;Mission;Modeling;Motivation;National Institute on Alcohol Abuse and Alcoholism;new technology;Online Systems;Participant;Pathway interactions;Pattern;peer;Phase;pilot test;post-doctoral training;Postdoctoral Fellow;Procedures;product development;programs;prototype;Public Health;Randomized;Recording of previous events;Reporting;Research;Research Personnel;revictimization;Risk;Risk Assessment;Role;Running;Safe Sex;Scientist;Self Medication;Severities;sex;Sexual Partners;sexual risk behavior;sexual risk reduction;sexual trauma;sexual victimization;Sexually Transmitted Diseases;skills;skills training;social;statistics;Surveys;Target Populations;Technology;technology intervention;Testing;theories;therapy design;therapy development;Time;tool;Training;transmission process;Trauma;treatment effect;Treatment Efficacy;Underserved Population;United States National Institutes of Health;Universities;usability;user centered design;Victimization;violent relationship;Washington;web-based intervention;Woman;Work;young adult;young woman

PROJECT_TITLE: Technology-based intervention for alcohol-related sexual risk behaviors in young women with sexual victimization histories


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Hematology;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Attenuated recycling of cellular components (autophagy) frequently occurs in aging immune cells and perturbs normal cell function and immunity. We will be the first to investigate how autophagy-impaired immune cells contribute to and are affected by neurodegeneration and AD. Our study may provide a new therapeutic avenue for patients with dementia, and potentially a paradigm for other age-associated tissue and organ-degenerative processes.

PROJECT_TERMS: adaptive immunity;Address;Affect;Age;age related;age related changes;Age related pathologies;age-related disease;Aging;aging brain;aging related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid beta-Protein;Animals;Attenuated;Autoimmunity;Automobile Driving;Autophagocytosis;Biometry;Body System;Bone Marrow;Brain;brain cell;Brain Drains;Cardiovascular Diseases;Cell Compartmentation;Cell Physiology;Cells;Central Nervous System;Chemicals;Cues;Data;Data Analyses;Defect;Dementia;Deterioration;Development;Elderly;Epigenetic Process;Erythroid Cells;Functional disorder;functional restoration;Generations;Genetic;Geroscience;Growth;hallmarks of aging;Hematology;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic stem cells;Homeostasis;Image;Imaging technology;Immune;immune function;Immune system;Immunity;immunosenescence;Impaired cognition;Impairment;improved;in vivo;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;innovation;insight;Knowledge acquisition;Lesion;Lymph;Lymphoid Cell;Macrophage;Mediating;Molecular Chaperones;monocyte;mouse model;Mus;Myeloid Cells;Natural Immunity;Nerve Degeneration;neuroinflammation;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;old mice;Organ;Organism;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Peripheral;Population;pre-clinical;precursor cell;prevent;Process;progenitor;protein aggregation;proteostasis;proteostasis loss;proteotoxicity;Public Health;Recurrence;Recycling;Regulation;Reporter;restoration;Role;stem cells;Stress;System;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic target;tissue degeneration;Tissues;tool;Work

PROJECT_TITLE: Proj 3 - Dysregulation of hematopoiesis and peripheral immune function and autophagy in aging and age-related diseases


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Immunization;Infectious Diseases;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health;Vaccine Related

PHR: Project Narrative Hepatitis B virus (HBV) remains endemic in many regions of the world, and prevention measures beyond vaccination are necessary to reach disease elimination goals. In sub-Saharan African settings like the Democratic Republic of the Congo (DRC), where HBV prevalence is 3.3% (~3.5 million infections), limited available evidence indicates that horizontal exposures in households and communities are driving endemicity. This proposal applies epidemiological, spatial, and genomic approaches to a large household study of HBV in Kinshasa, DRC, to understand HBV transmission dynamics and drivers of transmission and will inform expanded prevention programs towards elimination efforts.

PI_NAMEs: MORGAN, CAMILLE  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Africa;Africa South of the Sahara;African;antenatal;antenatal care;Asia;Automobile Driving;Behavior Therapy;Birth;Capital;career;Caring;Case/Control Studies;Cessation of life;Childhood;chronic infection;Cities;clinical practice;clinical training;clinically relevant;Communicable Diseases;Communities;community transmission;Country;Data;data management;Democratic Republic of the Congo;Demographic and Health Surveys;design;Disease;Dose;Enrollment;Epidemiologic Methods;Epidemiology;Fellowship;Future;Genetic;genetic analysis;Genetic Diseases;genetic epidemiology;Genetic Variation;Genomic approach;Geographic Locations;Geography;Goals;Hepatitis B Prevalence;Hepatitis B Transmission;Hepatitis B Vaccination;Hepatitis B Vaccines;Hepatitis B Virus;Hepatology;high risk;high risk population;HIV;Horizontal Disease Transmission;Household;improved;Individual;Infant;Infection;Infectious Disease Epidemiology;Infrastructure;innovation;Interdisciplinary Study;Intervention;Knowledge;member;Mentors;Methods;Molecular;Molecular Epidemiology;Morbidity - disease rate;mortality;Mothers;North Carolina;Odds Ratio;offspring;Organizational Objectives;Participant;pathogen;Pattern;Perinatal transmission;Phylogenetic Analysis;Physicians;Population;Population Genetics;Prevalence;Prevention Measures;Prevention program;Prevention strategy;programs;Prophylactic treatment;Research;Research Infrastructure;Research Proposals;Resources;Risk Factors;Role;Sampling;scale up;Scientist;screening;skills;spatial epidemiology;Statistical Models;STEM research;theories;Training;transactional sex;Translating;Translational Research;transmission process;Universities;Vaccination;Vaccines;Variant;Vertical Disease Transmission;Vertical Transmission;virology;Virus Diseases;Work;World Health Organization

PROJECT_TITLE: Spatial and molecular epidemiology of hepatitis B transmission in the Democratic Republic of the Congo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-A(20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention

PHR: Project Narrative Alzheimer’s disease and related dementias (AD/ADRD) are neurodegenerative disorders characterized by progressive dementia caused in part by proteoxicity and neuronal death. AD/ADRD are the 6th leading cause of mortality in the U.S. and affects approximately 5.4 million individuals in the U.S. This number is projected to increase to 13.8 million by mid-century. Unfortunately, despite significant research, the deliverables have been marginal due to complex multifactorial causes of AD/ADRD. Studies in this application will test new incisive hypotheses that restoring global metabolic function and preventing AD- related proteotoxicity by activating macroautophagy (MA) will delay cognitive decline. Studies will also determine whether dietary interventions that activate MA will delay cognitive decline in models of AD- related proteotoxicity.

PI_NAMEs: SINGH, RAJAT  (contact)

PROJECT_TERMS: Acceleration;Affect;Age;age group;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Amyloid beta-Protein Precursor;Animals;Autophagocytosis;Autopsy;Biochemical;Biometry;blood glucose regulation;Brain;Cartoons;Central Nervous System;Clinical;Cognition;Cognitive;Cognitive deficits;Collaborations;Complex;cost effective;Data;data integration;data management;Defect;Dementia;Development;Diabetes Mellitus;Diet;dietary;Dietary Intervention;Disease;disease model;Disease Progression;Disorientation;Energy Metabolism;Event;experimental study;Failure;Fatty acid glycerol esters;feeding;feeding plan;Funding;gamma secretase;Geroscience;Glucose;glucose metabolism;healthspan;Hippocampus;Homeostasis;Human;Hypothalamic structure;Image;imaging approach;Impaired cognition;improved;Incidence;Individual;Inflammatory;Insulin Resistance;Intervention;MAPT gene;Memory Loss;Metabolic;Metabolic dysfunction;Metabolic syndrome;Metabolism;Modeling;mortality;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutritional;Obesity;obesity prevention;Pathogenicity;Patients;Peripheral;Pharmacogenetics;Play;prevent;Pro-Opiomelanocortin;protein aggregation;Proteins;proteostasis;proteostasis loss;proteotoxicity;Public Health;Regulation;Research;response;Risk Factors;Role;Senile Plaques;Stress;System;tau Proteins;Testing;Tg2576;theories;Tissues;Toxic effect;Work

PROJECT_TITLE: Proj 4 - AD and metabolic regulation in aging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Progress in the development of in vivo biomarkers for the subregions of the medial temporal lobe (MTL), which have distinct functional roles and vulnerabilities to disease pathologies, has been hindered due to a lack of valid, standard segmentation protocols. The proposed research will leverage ongoing efforts and multicentric datasets to develop a harmonized MTL subregions segmentation protocol and validate it in clinical populations of early- stage Alzheimer’s disease and semantic variant Primary Progressive Aphasia. The proposed research is aligned with the goals of standardizing neuroimaging tools, and will have broad implications for reproducible research.

PI_NAMEs: OLSEN, ROSANNA KATHLEEN;WANG, LEI  (contact);WISSE, LAURA ELSKE MARIA

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Acceleration;Address;Adoption;Affect;Alzheimer's Disease;Amyloid beta-Protein;Anatomy;Atlases;Atrophic;automated segmentation;Autopsy;Biological Markers;biomarker development;Brain region;Brodmann's area;Cardiovascular Diseases;cardiovascular risk factor;Cerebrum;Clinical;cognitive function;Cognitive Science;Collaborations;Communities;comparison control;Computer software;Consensus;Data;Data Set;Dementia;Development;Disease;Educational Materials;Educational workshop;Elements;entorhinal cortex;Failure;Foundations;Funding;Goals;Hippocampus;Histology;Image;Impairment;improved;in vivo;International;Internet;Magnetic Resonance Imaging;Manuals;Masks;Measurement;Measures;medial temporal lobe;member;Mental disorders;Methods;mild cognitive impairment;MRI Scans;Nervous System Disorder;Neurodegenerative Disorders;neuroimaging;Neurologic;neuropathology;Outcome Measure;Pathologic;Pathologic Processes;Pathology;Patients;Persons;Population;Positron-Emission Tomography;Primary Progressive Aphasia;Procedures;Process;programs;Protocols documentation;Reporting;Reproducibility;Research;Resolution;Risk;Role;Scanning;Semantics;Specificity;Standardization;Structure;tau Proteins;Testing;tool;Training;Training and Education;Variant;Visualization;Volunteer Organization;Work

PROJECT_TITLE: A harmonized medial temporal lobe subregion segmentation protocol: an essential element for dementia research


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Alcohol use disorder and prenatal alcohol exposure continue to impose a tremendous burden on society and efficacious treatment options are severely lacking. The proposed work will investigate a novel aspect of alcohol exposure in adults and during pregnancy, which is mediated by direct interactions between metabolic and epigenetic processes. This new knowledge can be leveraged to develop novel treatments for these disorders.

PI_NAMEs: EGERVARI, GABOR  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Abstinence;Acetate-CoA Ligase;Acetates;Acetyl Coenzyme A;Acetylation;Acute;addiction;Adult;Affect;Alcohol consumption;alcohol effect;alcohol exposure;alcohol seeking behavior;alcohol testing;alcohol use disorder;Alcohols;Amygdaloid structure;Animal Model;Association Learning;Behavior;Behavioral;binge drinking;Biological;Brain;brain dysfunction;Brain region;career;Cells;Chromatin;cofactor;Cognition;Complex;Corpus striatum structure;craving;Cues;Data;Deposition;Development;Developmental Gene;Disease;disease phenotype;DNA;Dorsal;efficacious treatment;Enzymes;Epigenetic Process;epigenetic regulation;Ethanol;Ethanol Metabolism;Etiology;Executive Dysfunction;executive function;Faculty;fetal;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Development;Future;Gene Expression;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;Genomics;Hippocampus;Histone Acetylation;histone acetyltransferase;Histones;Human;in utero;inhibitor;insight;Isotope Labeling;Knock-out;Knowledge;Label;Learning;Link;Mediating;Memory;Metabolic;Metabolism;Modeling;mouse model;Mus;Nature;negative emotional state;Neurobiology;Neuronal Differentiation;Neurons;Neurophysiology - biologic function;novel;Nuclear;Nuclear Translocation;Pathway interactions;Peripheral;pharmacologic;Pharmacologic Substance;Play;Positioning Attribute;postnatal;Prefrontal Cortex;Pregnancy;prenatal;Process;programs;Property;Proteomics;Regulation;Relapse;Research;Rewards;Rodent Model;Role;Signal Transduction;skills;Societies;Source;Structure;Techniques;tenure track;Teratogens;Testing;Therapeutic;therapeutic target;Time;Training;treatment strategy;Ventral Striatum;Withdrawal;Work

PROJECT_TITLE: Epigenetic-metabolic aspects of alcohol use disorder and early developmental alcohol exposure


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Hodgkin's Disease;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Molecular mechanisms underlying virus-mediated B cell transformation are not completely understood. Through multi-dimensional, high-throughput single cell approaches, we will characterize B cell molecular signatures associated with pre-cancerous and cancerous states. Defining markers of early cancer development and accurate assessment of tumor heterogeneity is necessary to improve therapeutic strategies aimed at mitigating viral cancers.

PI_NAMEs: SKALSKY, REBECCA L (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Archives;Area;B-Cell Acute Lymphoblastic Leukemia;B-Cell Development;B-Cell Lymphomas;B-cell receptor repertoire sequencing;B-Lymphocytes;Biological;Cancer Burden;Cancerous;Cell Culture Techniques;Cell Line;Cell surface;cell transformation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chronic infection;CRISPR screen;Dependence;Development;Diagnostic;Differentiation Antigens;Dimensions;Disease;EBV-associated disease;Environment;Epstein Barr Nuclear Antigen 3;Epstein-Barr pathogenesis;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Malignant Neoplasm;experimental study;gammaherpesvirus;Gene Expression;gene product;genetic manipulation;genetic signature;Genetic Transcription;Goals;Growth;Heterogeneity;Human;Human Herpesvirus 4;Immune;immune checkpoint;Immunocompromised Host;Immunophenotyping;improved;In Vitro;in vivo;Individual;infected B cell;Infection;Infectious Agent;infectious disease model;Integration Host Factors;IRF4 gene;Knowledge;latent infection;Link;LMP1;Longitudinal Studies;Lymph Node Tissue;lymphoblastoid cell line;Lymphocryptovirus;Lymphoid Tissue;Lymphoma;Lymphoproliferative Disorders;Macaca mulatta;Malignant Neoplasms;Maps;Measures;Mediating;Methods;MicroRNAs;Modeling;Molecular;molecular dynamics;molecular marker;Molecular Profiling;MS4A1 gene;multiple omics;mutant;Nature;Pathway interactions;Patients;permissiveness;pre-clinical;Pre-Clinical Model;Predisposition;premalignant;Process;programs;Proliferating;Proliferation Marker;Property;Refractory;Resolution;Resources;Rest;Rhesus;Sampling;Side;single-cell RNA sequencing;Techniques;Therapeutic;time use;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;tumor;Tumor Antigens;tumor heterogeneity;Tumor Tissue;Viral;Viral Cancer;Viral Proteins;Virus;Virus Diseases

PROJECT_TITLE: Characterizing single cell states of activated and transformed B cells in rhesus macaque models


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Project Narrative Randomized controlled trials (RCTs) are considered the “gold standard” study design to determine the effectiveness of therapeutic interventions; however, they often suffer from rigor and transparency problems, leading to potential research waste. The proposed research will develop a set of natural language processing (NLP) methods to identify information related to rigor and transparency from RCT reports (protocols and results publications). These methods will support tools and resources that assist stakeholders of clinical research in maintaining high reporting standards, synthesizing information on methodological quality, and fostering open science practices, and will contribute to improvements throughout the scientific ecosystem, leading to better patient care and health policy.

PI_NAMEs: KILICOGLU, HALIL  (contact);MAYO-WILSON, EVAN

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: Adherence;base;Characteristics;Classification;clinical care;clinical practice;Clinical Practice Guideline;Clinical Research;computable knowledge;Computing Methodologies;Consumption;design;Ecosystem;editorial;effectiveness evaluation;Effectiveness of Interventions;empowerment;Evidence Based Medicine;Fostering;Foundations;Goals;Guideline Adherence;Guidelines;Health Policy;Human;improved;Information Retrieval;Journals;Literature;Medical;Methodology;Methods;Modeling;Natural Language Processing;Online Systems;Ontology;open data;open label;Outcome;Participant;Patient Care;Patients;Peer Review;prevent;Process;Protocols documentation;Publications;Publishing;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Readability;Recommendation;Reporting;Research;Research Design;Research Methodology;Resources;Risk Assessment;Screening procedure;Selection Bias;Semantics;Structure;study characteristics;support tools;systematic review;Terminology;Text;text searching;therapeutic effectiveness;Therapeutic Intervention;Time;tool;wasting

PROJECT_TITLE: Computational Methods, Resources, and Tools to Assess Transparency and Rigor of Randomized Clinical Trials

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Dissemination and Implementation Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROGRAM NARRATIVE Low- and middle-income countries (LMIC) face a huge and growing burden of chronic conditions and the research capacity to address these issues is extremely limited. This training program in research, implementation and team science will train 24 multidisciplinary researchers from nursing, medicine and public health in Ethiopia who will launch careers focused on designing, implementing, and evaluating interventions, programs, and policies to address chronic conditions.

PI_NAMEs: ALI, MOHAMMED KUMAIL;GARY, REBECCA A (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;Attention;Cardiometabolic Disease;career;Chronic;Chronic Disease;Country;design;Discipline;Discipline of Nursing;Ensure;Ethiopia;Funding;higher education;implementation science;Individual;Institution;Interdisciplinary Study;Kidney Diseases;life span;low and middle-income countries;Medicine;Mentors;Mentorship;Policies;Postdoctoral Fellow;Prevention;Productivity;programs;Public Health;recruit;Research;Research Personnel;response;rural setting;Science;Shapes;skills;Training;Training Programs;Translations;Universities;urban setting;Work

PROJECT_TITLE: Training on ImplemenTAtioN and team Science for NCD Control (TITANS) program


NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Substance Misuse

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Persistence for longer periods of time and during periods of heavy immune surveillance may select for features that allow infected cells to evade detection and clearance by the immune system. Such features may be enriched in infected cells that entered the reservoir early in untreated infection. A better understanding of features that make patient-derived reservoir cells more resistant to clearance may inform the development of improved clearance strategies.

PI_NAMEs: ARCHIN, NANCIE MARIE;JOSEPH, SARAH BETH (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Adjuvant;Affect;Age;Antigen Presentation;Antigens;antiretroviral therapy;Autologous;Biological Assay;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Separation;Cells;Cholesterol Homeostasis;Clonal Expansion;cytokine;Cytotoxic T-Lymphocytes;design;Detection;Development;Early identification;Effector Cell;efficacy evaluation;Environment;Epigenetic Process;feature selection;gene repression;Genetic;Genetic Transcription;Genome;Genomics;Goals;Half-Life;HIV;HIV Antigens;HIV Infections;HIV-1;Immune;immune clearance;immune function;Immune response;Immune system;Immunologic Surveillance;immunoregulation;improved;Individual;Infection;Inflammatory;inhibitor;Integration Host Factors;integration site;Lymphocyte Function;Malignant Neoplasms;Measures;Mediating;Methodology;Mitogens;novel strategies;Participant;Patients;Persons;Phenotype;Population;Predisposition;pressure;Property;Proteins;Proviruses;Refractory;Resistance;response;Serum;Signal Transduction;T-Lymphocyte;Testing;Time;Transforming Growth Factor beta;Viral;Viral reservoir;Virus;Work

PROJECT_TITLE: Identifying Roadblocks to Antigen Expression and Enhancing Killing of HIV-Infected Cells That Are Refractory to Clearance


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunotherapy;Precision Medicine;Regenerative Medicine;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Approval was recently obtained for the treatment of triple negative breast cancer with neo- adjuvant therapy, and adjuvant immunotherapy. Some patients may be overtreated, and others may develop resistance to therapy that is undetected until disease progression. We are applying tissue engineering technologies to develop a niche for the monitoring the systemic effects of residual disease as reflected by the presence of immune and/or tumor cells, which we apply to reduce undertreatment and identify resistance to therapy at early times.

PI_NAMEs: JERUSS, JACQUELINE SARA;SHEA, LONNIE D (contact)

PROGRAM_OFFICER_NAME: RIZWAN, ASIF M

PROJECT_TERMS: Adjuvant;Adjuvant Therapy;advanced disease;Blood;Blood Vessels;Breast Cancer Cell;burden of illness;cancer cell;cancer initiation;Cells;chemotherapy;Clinical Management;Clinical Research;cost;Disease;Disease Progression;Disease regression;Disease Surveillance;Distal;Distant;Early Intervention;Effectiveness;Elements;Engineering;Excision;Foreign Bodies;Gene Expression Profile;Gene Expression Profiling;Goals;Growth;Histologic;Histology;Home;Immune;immune cell infiltrate;immune checkpoint blockade;Immune system;Immunologics;Immunotherapy;Implant;improved;improved outcome;In complete remission;in vivo;individualized medicine;Infiltration;liquid biopsy;Location;longitudinal analysis;Lung;Macrophage;Malignant Breast Neoplasm;Metastatic breast cancer;minimal risk;Molecular;Molecular Analysis;molecular phenotype;Monitor;Morbidity - disease rate;Mus;Myeloid-derived suppressor cells;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;new technology;Operative Surgical Procedures;Organ;Pathologic;Patient Self-Report;patient stratification;patient subsets;Patients;Pattern;Phenotype;Primary Neoplasm;Procedures;prognostic signature;prognostic value;recruit;Recurrence;Recurrent disease;Research;Residual Neoplasm;Resistance;Resistance development;resistance mechanism;response;scaffold;Site;Solid;Solid Neoplasm;success;Symptoms;Systemic disease;T-Lymphocyte;targeted treatment;Technology;Therapeutic;therapy resistant;Time;Tissue Engineering;Tissues;tool;Treatment Efficacy;treatment response;triple-negative invasive breast carcinoma;tumor;tumor progression

PROJECT_TITLE: Tissue engineering tools for monitoring the cellular and molecular response to therapy

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Substance Misuse

PHR: Narrative Psychiatric disorders, including alcohol use disorder and other stress-related disorders (e.g., post-traumatic stress disorder, major depressive disorder and others), are a set of chronic, non-communicable diseases (NCDs) that constitute a global public health problem of enormous economic, social, and medical cost internationally. Low and middle-income and developing countries such as Thailand are disproportionately affected due to both unique stressors experienced and less well-established institutional infrastructures (facilities, personnel, and research) dedicated to the understanding, treatment and prevention of psychiatric disorders; especially so during the COVID-19 pandemic when many countries, including Thailand, experienced extensive shutdowns and an interruption of the tourist industry, a major source of income. In the current application, we propose a collaborative research training program in the interdisciplinary and translational research of stress, alcohol use and psychopathology between three Thai institutes (the Chulalongkorn University Faculty of Medicine (a leading medical research center in Thailand and established collaborator, the lead Thai site), Phramongkutklao Hospital and Medical College in Bangkok, Thailand (a new collaborator), and Prince of Songkla University in Hat Yai, Thailand (also a new collaborator)) and the Yale University School of Medicine in the U.S.

PI_NAMEs: GELERNTER, JOEL ;POTENZA, MARC N (contact)

PROJECT_TERMS: Address;Affect;Alcohol consumption;Alcohols;Chronic;Clinical;clinical translation;Clinical Trials;Collaborations;Communities;community research;Dedications;design;Developing Countries;Development;Disease;Drug Addiction;economic disparity;Economics;Environment;experience;Faculty;Fellowship;Genetic;Genetic study;Goals;Health;Health Professional;Hospitals;implementation research;Income;Infrastructure;Institution;Interdisciplinary Study;International;Lead;Medical Care Costs;medical schools;Medicine;Mental disorders;Molecular Biology;multidisciplinary;Names;neuroimaging;Policy Research;Population;Postdoctoral Fellow;pre-doctoral;prevent;Prevention;programs;Psychiatry;Psychopathology;Psychopharmacology;Public Health;Recording of previous events;Research;Research Personnel;Research Training;Scientist;Site;social;Stress;stress related disorder;Substance Use Disorder;Thailand;Training;Training Programs;Translational Research;Universities

PROJECT_TITLE: The Robert T. Malison Yale-Chulalongkorn Stress, Alcohol Use and Psychopathology Training Program


NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

PHR: Project Narrative HIV incidence and mortality are increasing markedly in Georgia despite many available evidence-based interventions to prevent HIV, which are sub-optimally implemented due to challenges in delivery in key populations like PWID and MSM, where the epidemic is concentrated. The proposed Georgian Implementation Science Fogarty Training (GIFT) Program is designed with short-, medium- and long-term training to address the current implementation gap through training of 4 faculty and 6 doctoral students at Ilia State University (in collaboration with Yale University), creating a regional resource and training hub and to provide a summer bootcamp training program each year for local and regional implementers.

PI_NAMEs: ALTICE, FREDERICK LEWIS (contact);ESSERMAN, DENISE ;KIRTADZE, IRMA

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: AIDS prevention;Biometry;Biostatistical Methods;Central Asia;Collaborations;Communities;Counseling;Data;Databases;design;Discrimination;doctoral student;Eastern Europe;Educational Curriculum;Elements;Epidemic;Evidence based intervention;experience;Faculty;Government;HIV;Hybrids;implementation research;implementation science;implementation trial;Infection;Injecting drug user;Institution;Institutionalization;international partnership;Knowledge;Learning;low and middle-income countries;Medicine;men who have sex with men;Mentors;Modeling;mortality;Needle-Exchange Programs;next generation;opioid agonist therapy;Outcome;Phase;Population;Populations at Risk;pre-exposure prophylaxis;Prevalence;prevent;programs;Public Health;Research;Research Methodology;Research Personnel;Resources;skills;social stigma;Student recruitment;Teacher Professional Development;Testing;Time;Training;Training Programs;treatment as prevention;Universities

PROJECT_TITLE: Georgian Implementation Science Fogarty Training Program (GIFT)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(56)]


NIH_SPENDING_CATS: Asthma;Health Effects of Indoor Air Pollution;Lung

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The proposed research is relevant for human health and disease because allergic asthma is currently on the rise in the United States, therefore there is a need to understand the mechanisms that drive disease in order to identify new targets for the development of therapeutic options. Our proposal has identified Blimp-1 as a novel tissue-specific driver of allergic asthma that is required for the development of allergen-specific Th2 cells known to drive inflammation of the lung and subsequent airway inflammation. Therefore, this research has translational significance for patients with asthma while also elucidating basic mechanisms of the pathogenesis of allergic disease and T cell responses to allergens.

PI_NAMEs: POHOLEK, AMANDA CATHERINE (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: adaptive immune response;airway inflammation;Allergens;Allergic;Allergic Disease;Asthma;Autoimmunity;Automobile Driving;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Physiology;cell type;Cells;Chronic;chronic inflammatory lung disease;cytokine;Data;Dendritic Cells;Development;Disease;Effector Cell;effector T cell;environmental allergen;Exposure to;Extrinsic asthma;GATA3 gene;Generations;Health;Health Care Costs;Hour;Human;Immune;Immune response;Immunity;Immunization;In Situ;Inflammation;Inflammatory;inflammatory milieu;Inhalation;Interleukin-10;Interleukin-13;Interleukin-4;Interleukin-5;ITGAX gene;Kinetics;Lung;Mediastinal lymph node group;Mediating;Memory;memory CD4 T lymphocyte;Molecular;Morbidity - disease rate;mouse model;Mus;novel;Pathogenesis;Pathway interactions;Patients;Phenotype;Play;Production;Pulmonary Inflammation;Pyroglyphidae;recruit;Reporter;Reporting;Research;response;Role;Route;Shapes;Site;Skin;STAT3 gene;Structure of parenchyma of lung;System;T cell differentiation;T cell response;T memory cell;T-Cell Activation;T-Cell Development;T-Lymphocyte;Tamoxifen;Testing;Th2 Cells;Therapeutic;therapeutic development;therapeutic target;Tissues;Transcription Repressor;transcriptome;transcriptome sequencing;United States;Work

PROJECT_TITLE: Lung-specific expression and function of Blimp-1 in T cells impacting allergic asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Substance use, particularly the use of stimulants and opioids in the fourth wave of the opioid epidemic, are a major public health problem. Research is needed to develop new substance use disorder treatments and to determine how to best broadly disseminate the treatments that are currently available and effective. The National Institute on Drug Abuse’s National Drug Abuse Treatment Clinical Trials Network (CTN) and the Big South/West Node will contribute their expertise to solving the substance use problems impacting our Southern region as well as nationally.

PI_NAMEs: POTTER, JENNIFER SHARPE;SHOPTAW, STEVEN J;TRIVEDI, MADHUKAR H. (contact)

PROGRAM_OFFICER_NAME: BERTZ, JEREMIAH WILLIAM

PROJECT_TERMS: Academy;Acceleration;addiction;Address;African American;AIDS prevention;American;American Indians;Ancillary Study;Area;Arkansas;Buprenorphine;Bupropion;California;Caring;Cause of Death;Clinical;clinical care;Clinical Treatment;Clinical Trials Network;cohort;Collaborations;Communities;comorbidity;Databases;design;Development;dissemination science;Doctor of Philosophy;Dose;Drug abuse;Drug usage;Electronic Health Record;Ethnic Population;Evidence based practice;experience;Family Physicians;Foundations;Funding;Genetic Complementation Test;Geographic Locations;Geography;Goals;Health;health care settings;Health Sciences;Healthcare Systems;Hepatitis C virus;Hispanic;HIV;HIV Seropositivity;HIV/HCV;hospital readmission;Immigrant;implementation science;implementation study;improved;indexing;Informatics;Infrastructure;innovation;International;Lead;Leadership;Length of Stay;Los Angeles;Louisiana;Measurement;Medical center;medically underserved population;Mentors;Methamphetamine;Methamphetamine use disorder;metropolitan;Mission;Modeling;Multi-Institutional Clinical Trial;multi-site trial;Naltrexone;Names;National Institute of Drug Abuse;next generation;novel;Oklahoma;Opioid;opioid epidemic;opioid use disorder;Patient Discharge;patient population;Peer Review;Persons;Pharmacotherapy;Policy Maker;Population;prevention practice;Primary Care;Productivity;programs;Public Health;Publications;Publishing;racial diversity;racial population;readmission risk;Recovery;Research;Research Design;Research Personnel;Resources;response;Risk;risk prediction;Rural;rural area;rural setting;Scholars Program;Science;Scientist;screening;Senior Scientist;Site;Solid;Stimulant;stimulant use;stimulant use disorder;substance misuse;substance use;Substance Use Disorder;Texas;therapy development;Training;Transcranial magnetic stimulation;Translational Research;Underinsured;underserved area;Universities;urban setting;Workforce Development

PROJECT_TITLE: NIDA Clinical Trials Network: Big South/West Node


NIH_SPENDING_CATS: Autism;Bioengineering;Biotechnology;Brain Disorders;Genetic Testing;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Prevention

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: NARRATIVE To systematically investigate the mechanisms of risk genes implicated in diseases and disorders including autism spectrum disorder and neurodevelopmental delay, we will establish functional genomic technologies called Perturb-map and Perturb-seq as in vivo genetic screening tools. We will combine a series of genomic technologies including tissue clearing, high-throughput imaging, single-cell multi-omics, and in vivo CRISPR- Cas9 gene editing, to seek cellular mechanisms across brain regions and their effects in cytoarchetecture and neuronal projectome in intact, whole brains. This interdisciplinary approach is set to establish modular and broadly applicable tools to allow discoveries of key anatomical, cellular, molecular, and circuit-level mechanisms related to diverse genetic variants in human diseases and disorders.

PI_NAMEs: JIN, XIN  (contact)

PROGRAM_OFFICER_NAME: DI FRANCESCO, VALENTINA

PROJECT_TERMS: 3-Dimensional;Address;Affect;Anatomy;Artificial nanoparticles;autism spectrum disorder;Biological;Biological Process;Biology;Brain;Brain region;brain research;brain tissue;cell motility;cell type;Cells;Cellular Morphology;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;Corpus striatum structure;CRISPR/Cas technology;Data;delivery vehicle;Detection;Development;Disease;Elements;Embryonic Development;Equity;experience;flexibility;fluorescence imaging;functional genomics;Gene Delivery;gene editing technology;Gene Expression;gene function;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic Screening;Genetic screening method;Genetic study;genetic variant;Genome;genomic tools;Genomics;Goals;Guide RNA;Harvest;human disease;Human Genetics;Image;improved;In Situ;in vivo;interdisciplinary approach;Investigation;Light;Location;Maps;Methodology;Methods;Molecular;Morphology;multiple omics;Names;Nature;Neocortex;neural circuit;Neurons;neuropsychiatric disorder;Neurosciences;novel;Optics;Pathologic;Phenotype;Population;Reaction;Reporter;Resolution;Risk;risk variant;Science;screening;Screening procedure;Series;Serotyping;single cell genomics;Spatial Distribution;Specificity;System;Technology;Thick;Tissues;tool;transgene delivery;Transgenes;Transposase;Work

PROJECT_TITLE: In vivo Perturb-map: scalable genetic screens with single-cell and spatial resolution in intact tissues


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE The proposed training grant, Advancing Implementation Research Capacity in Vietnam (ARC), will strengthen Implementation Science (IS) research capacity at the individual and institutional level at Hanoi University School of Public Health in Vietnam and regionally through a partnership with Laos’ University of Health Sciences. Engaging students, research faculty and public health professionals in IS training has the potential to accelerate implementation and scale-up of noncommunicable disease (NCD)-related evidence-based interventions in the context of HIV care in Vietnam and reduce the burden of NCDs among people living with HIV/AIDS.

PI_NAMEs: NGUYEN, BICH NGOC;SHELLEY, DONNA R (contact);YANG, LAWRENCE H

PROJECT_TERMS: Academia;Acceleration;Active Learning;antiretroviral therapy;attributable mortality;career;Career Mobility;Caring;Collaborations;Data;Disease;Educational Curriculum;Enrollment;Equity;Evidence based intervention;experience;forging;Foundations;Funding;Future;global health;Goals;graduate student;Health;health disparity;Health Policy;Health Professional;Health Sciences;Health system;Healthcare Systems;High Prevalence;HIV;HIV Infections;HIV/AIDS;implementation research;implementation science;improved;Individual;Institution;Institutionalization;Intervention;Investments;Knowledge;Laos;Learning;low and middle-income countries;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;New York;Outcome;Policies;Policy Maker;population health;prevent;programs;Public Health;Research;research faculty;Research Methodology;Research Personnel;Risk Factors;scale up;Schools;skills;System;Tobacco use;Training;Training Programs;Translational Research;Translations;United States National Institutes of Health;Universities;Vietnam


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Diffuse intrinsic pontine glioma (DIPG), the leading cause of brain tumor-related mortality of childhood in the US, is driven by aberrant chromatin structures. This grant application proposes to better elucidate the molecular basis for these aberrations. Insights gained from the experiments proposed here will pave way for future therapeutic development to ultimately allow children burdened with this disease to live longer, healthier lives.

PI_NAMEs: REICH, TYLER J (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Ablation;Achievement;Address;Affinity;anti-cancer;Applications Grants;Binding;Biochemical;Biochemistry;Biological Assay;Biology;Brain Neoplasms;Cancer Biology;career;cell growth;Cell Maintenance;Cell Proliferation;cell type;Cells;Child;Childhood;Childhood Brain Neoplasm;Childhood Malignant Brain Tumor;Chromatin;Chromatin Structure;Clinical;Clinical Trials;Collaborations;Complex;CpG Islands;CRISPR/Cas technology;Data;defined contribution;design;Development;Diffuse;Diffuse intrinsic pontine glioma;Disease;DNA;Ensure;Environment;Event;experimental study;Fatal Outcome;Foundations;Future;Gene Expression;gene repression;Gene Silencing;Genes;Genome;genome-wide;Genomics;Glioma;glioma cell line;Gliomagenesis;Growth Suppressor Genes;Higher Order Chromatin Structure;Histone H3;Histones;Human;human disease;improved;In Vitro;inhibitor;innovation;insight;Institution;Kinetics;Life;loss of function mutation;Lysine;Malignant Neoplasms;Measures;Mediating;Mentors;Methionine;Methylation;Methyltransferase;Modeling;Molecular;mortality;mouse model;Multienzyme Complexes;Mutate;Mutation;novel therapeutics;oncohistone;Outcome;Pathogenesis;Patients;Physicians;Polycomb;Post-Translational Protein Processing;PRC1 Protein;preclinical efficacy;Predisposition;prevent;Prognosis;promoter;Proteomics;Rationalization;recruit;Recurrence;Regulation;Reporting;Research;Research Personnel;Residual state;Resistance;Resources;Role;Scientist;Series;Site;Specific qualifier value;Testing;Therapeutic;therapeutic development;therapeutic target;Tissues;Training;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;Universities;Variant;virtual;Wisconsin;Work

PROJECT_TITLE: Defining the Roles of Polycomb Repressive Complex 2 (PRC2) Subcomplexes in H3 K27M Gliomas


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Obesity

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: Project narrative The proposed research is relevant to public health, as obesity and NAFLD/NASH create major economic and social burdens. Deciphering the underlying mechanisms of obesity and NAFLD/NASH are important to identify and validate pharmacologically viable targets. Successful completion of this project will unravel the role of the E3 ubiquitin ligase Ube4A in hepatocyte metabolism and survival and in the development and progression of NAFLD/NASH.

PI_NAMEs: CHAKRABORTY, ANUTOSH  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: adenoviral mediated;Adipocytes;Biological Assay;Caspase;Cell Death;Cell Death Induction;Cell Survival;Cells;Cellular Metabolic Process;Cellular Stress;Cessation of life;Cirrhosis;Dependovirus;Development;diet-induced obesity;Diphosphates;Disease;DNA Damage;Economics;Endoplasmic Reticulum;endoplasmic reticulum stress;Energy Metabolism;Enzymes;Fatty Acids;Fatty Liver;Genome;glucose uptake;Glycolysis;Goals;Hepatocyte;Homeostasis;Human;Hyperinsulinism;Impairment;In Vitro;in vivo;Inflammation;inhibitor;Injury;innovation;Inositol;Insulin Resistance;insulin sensitivity;insulin signaling;Knock-out;Knockout Mice;Link;Liver;liver injury;Malignant Neoplasms;Mediating;Mediator;Metabolic;Metabolic dysfunction;Metabolism;Modeling;Mus;mutant;Mutate;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Obese Mice;obese person;Obesity;obesogenic;overexpression;Oxidative Stress;Oxidative Stress Induction;Oxygen Consumption;Palmitates;Pathway interactions;Patients;pharmacologic;Pharmacotherapy;prevent;Process;Production;protein degradation;Proteins;Proteome;proteostasis;Public Health;Regulation;Research;response;Risk Factors;Role;Site;social;Stress;stressor;System;Testing;Therapeutic;Tissues;tool;transcriptome sequencing;Tunicamycin;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;uptake;Vitamin K 3;western diet

PROJECT_TITLE: Determining hepatocyte-specific mechanisms by which Ube4A regulates NAFLD/NASH

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Health Services;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Sepsis

ORG_CITY: MIAMI

ORG_NAME: INFOTECH SOFT, INC.

ORG_STATE: FL

PHR: Deep-CDS is a cloud-based semantic data lake for clinical decision support that integrates data across a hospital’s informatics resources to capture a comprehensive picture of each patient’s health status and utilizes a deep graph generative model to assess risk of developing sepsis-related symptoms and complications.

PI_NAMEs: KABUKA, MANSUR R. (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Admission activity;Adverse event;Algorithms;Antibiotics;Artificial Intelligence;Back;Businesses;Caregivers;Caring;Cessation of life;Clinical;clinical care;clinical decision support;Clinical Practice Guideline;clinical predictors;cloud based;Computer software;Data;data harmonization;data ingestion;data integration;data lake;data modeling;Data Set;Death Rate;deep learning;deep learning model;Deterioration;Development;Diagnosis;Diagnostic;diagnostic tool;Early identification;Engineering;Ensure;Evaluation;evidence base;Fast Healthcare Interoperability Resources;Feedback;Floor;generative models;Grant;Graph;Health;health data;Health Personnel;Health Professional;Health Status;Hospital Mortality;Hospitalization;Hospitals;Hour;improved;improved outcome;Incidence;inpatient service;Inpatients;Intensive Care;Intervention;Knowledge;knowledge graph;knowledgebase;Laboratories;large datasets;Learning;learning progression;Legal patent;Length of Stay;Libraries;Life;Machine Learning;Maintenance;Managed Care;member;Metadata;Methods;model generalizability;Modeling;Monitor;Morphologic artifacts;mortality risk;National Institute of General Medical Sciences;Nurses;Patient Admission;Patient Monitoring;patient population;Patient risk;Patient Transfer;Patient-Focused Outcomes;Patients;Phase;Physicians;pilot test;point-of-care diagnostics;Population;predictive modeling;Process;Prognosis;prototype;Publishing;Quality of Care;Reporting;Resource Informatics;response;Risk;Risk Assessment;Risk Factors;Risk Reduction;risk stratification;Semantics;Sepsis;septic;septic patients;Septic Shock;Serious Adverse Event;Services;Specificity;Survival Rate;Symptoms;System;Taxonomy;Technology;Testing;Therapeutic;Time;tool;Training;training data;treatment response;trend;trend analysis;United States;Update;usability;user centered design;ventilation;Visualization

PROJECT_TITLE: Deep-CDS: Deep Learning Semantic Data Lake for Clinical Decision Support


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Hematology;Networking and Information Technology R&D (NITRD);Orphan Drug;Patient Safety;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease;Telehealth

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: Project Narrative/Public Health Relevance Statement Hydroxyurea (HU) is a commonly prescribed disease-modifying medication, approved by the Food and Drug Administration (FDA), for adolescents with sickle cell disease; however, low hydroxyurea adherence limits the use of this medication in clinical practice. In addition, the longitudinal relationship between hydroxyurea adherence and patients' health-related quality of life, such as pain, fatigue and depression, has not been studied, and, to date, mobile health or mHealth interventions for hydroxyurea adherence have not been evaluated in adolescents with sickle cell disease. This study will examine the relationship between hydroxyurea adherence and health-related quality of life overtime among adolescents with sickle cell disease, and determine if a mobile or smartphone app (HU-Go) is a feasible and an acceptable intervention that can improve hydroxyurea (HU) adherence in this population.!

PI_NAMEs: BADAWY, SHERIF MOHAMED (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adolescent;Adolescent and Young Adult;Adopted;Affect;African American;Age;Age Months;American;Award;behavior change;Behavior Therapy;Behavioral;behavioral clinical trial;behavioral health intervention;Biological Markers;Biometry;career;career development;Cellular Phone;Chronic;Chronic Disease;clinical outcome assessment;clinical practice;Clinical Trials;Collaborations;compliance behavior;cost effectiveness;Cross-Sectional Studies;Data;debilitating pain;Dedications;design;Development;Development Plans;Disease;Education;efficacy evaluation;Electronics;Environment;Evaluation;evidence base;experience;Fatigue;feasibility testing;Foundations;Future;Genetic Diseases;Goals;Guidelines;Habits;Health;Health Care Costs;health care service utilization;health related quality of life;Health Services Research;Healthcare;hydroxyurea;improved;Individual;Institution;interest;Intervention;Intervention Studies;K-Series Research Career Programs;Laboratories;Lead;Learning;Live Birth;Measures;medical schools;medication compliance;Mental Depression;Mentors;mHealth;mhealth interventions;Minority Groups;mobile application;mobile computing;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Organ;Outcome;Outcomes Research;Pain;patient oriented;Patient Outcomes Assessments;patient-level barriers;Patients;pediatric department;Pediatric Hematologist;Pediatric Hospitals;Perception;Pharmaceutical Preparations;Physicians;poor health outcome;Population;Prospective, cohort study;prototype;Psychological Factors;public health relevance;Pulmonary Heart Disease;Randomized, Controlled Trials;Recommendation;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Review Literature;Scientist;Self Determination;Self Management;Sickle Cell Anemia;skills;smartphone application;Social isolation;Stroke;Structure;Surveys;Tablets;Techniques;Technology;Text Messaging;theories;Theory of Change;therapy development;Training;United States Food and Drug Administration;Universities;usability;user centered design;Variant;Work

PROJECT_TITLE: An mHealth Strategy to Improve Medication Adherence in Adolescents with Sickle Cell Disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative People who are diagnosed with thyroid cancer often receive radioactive iodine therapy. This therapy can lead to many symptoms that patients did not expect. Patients also report difficulty managing these symptoms. The first goal of this project is to develop a web-based intervention that provides information and support to patients with thyroid cancer who receive radioactive iodine therapy. The second goal is to test if the intervention reduces patient symptom burden.

PI_NAMEs: CARR, ALAINA L (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: acceptability and feasibility;Address;Adverse effects;Aftercare;alternative treatment;Appointment;Behavior Therapy;Behavioral;Behavioral Model;Cancer Control;Cancer Patient;cancer therapy;cancer type;career development;Caring;Cellular Phone;Clinical;Clinical Trials Design;common symptom;Computers;Control Groups;coping;Coping Skills;Data;design;Development;Devices;Diagnosis;digital health;digital technology;Distress;Education;Educational Intervention;Eligibility Determination;empowerment;Endocrine;Enrollment;European Organization for Research and Treatment of Cancer;Evidence based intervention;experience;Feedback;Focus Groups;Follicular thyroid carcinoma;follow-up;Frequencies;Frustration;Functional disorder;Future;Goals;Gold;Grant;health related quality of life;Individual;Information Management;Intervention;intervention effect;Interview;Knowledge;lacrimal;Lacrimal gland structure;Late Effects;Leadership;Malignant neoplasm of thyroid;Malignant Neoplasms;Measures;Mentors;Mentorship;Nose;novel;Online Systems;Oral health;oral mucositis;Pain;Papillary Carcinoma;Participant;patient population;Patient Selection;Patient-Focused Outcomes;Patients;Persons;Phase;pilot test;Population;primary outcome;Prognosis;Provider;Radioactive Iodine;radioiodine therapy;Randomized;Randomized, Controlled Trials;Recommendation;reduce symptoms;Reporting;Research;Research Design;Research Personnel;Salivary;Salivary Glands;Second Primary Cancers;secondary outcome;Self Efficacy;side effect;skills;Sleep;social cognitive theory;Social Functioning;Stress;support tools;survival outcome;Survival Rate;survivorship;Symptom Burden;symptom management;symptom treatment;symptomatic improvement;Symptoms;System;Technology;technology intervention;Testing;therapy design;therapy development;tool;Training;treatment as usual;treatment comparison;treatment effect;Treatment Efficacy;Treatment Side Effects;understudied cancer;usability;web-based intervention;Writing

PROJECT_TITLE: The development of a technology-based information support intervention (iSupport) among patients with differentiated thyroid cancer post radioactive iodine therapy


ORG_CITY: College Station

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

PHR: Protein radicals are involved in a range of both beneficial as well as harmful chemical reactions in living organisms. Little is know about these species since they are highly challenging to study in their natural protein environment and in model systems. We are developing a library of well-structured model proteins that has enabled detailed studies of the fundamental chemical properties of amino-acid radicals.

PI_NAMEs: TOMMOS, CECILIA  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: absorption;Agreement;Amino Acids;analog;Benchmarking;Biological;Biological Models;cell injury;chemical property;chemical reaction;Chemicals;cofactor;Coupled;Cysteine;Data;density;Dependence;design;Dimerization;driving force;electron donor;Electron Spin Resonance Spectroscopy;Electron Transport;Electrons;Encapsulated;Engineering;Environment;Enzymes;Experimental Designs;Family;Film;Foundations;Generations;Glycine;Goals;Hydration status;Hydrogen;in vivo;Kinetics;Libraries;Life;Location;Maps;Measures;Mediator;Metals;Methods;Micelles;Modeling;molecular mechanics;Motion;Nature;NMR Spectroscopy;novel;Organism;Outcome;oxidation;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;Photosensitizing Agents;Planet Earth;Positioning Attribute;Process;Property;Proteins;Protocols documentation;Protons;Quantum Mechanics;Reaction;Relaxation;Research Project Grants;Role;Route;Ruthenium;Sampling;Side;Site;Spectrum Analysis;Structure;System;Testing;Theoretical model;theories;Thermodynamics;Time;tool;Tryptophan;two-dimensional;Tyrosine;Vertebral column;Water;Y protein

PROJECT_TITLE: Understanding Protein Radicals

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]