ADMINISTERING_IC: AA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Narrative Alcohol exposure is associated with aberrations in alternative splicing, but the functional consequences of this are unknown. Genome engineering approaches using Drosophila melanogaster provide an opportunity to understand this at a highly mechanistic level. Here we interrogate how alcohol-induced aberrant splicing of Drosophila D2-like Receptor influences behavior and neural dynamics, which will establish a connection between dynamic alternative splicing and changes in nervous system function.

PI_NAMEs: BROWN, TARIQ  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Adult;Affect;Alcohol consumption;alcohol exposure;alcohol memory;alcohol response;alcohol use disorder;Alcohols;Alternative Splicing;Amino Acids;Axon;Behavior;Behavior assessment;behavior change;behavior influence;Behavioral;Biological Assay;Brain;Calcium;career;cell type;Cells;Cellular Neurobiology;chronic alcohol ingestion;Communication;Corpus striatum structure;Cues;Custom;Data Analyses;Dendrites;Development;Dopamine;Dopamine D2 Receptor;Dopamine Receptor;dopaminergic neuron;Drosophila genus;Drosophila melanogaster;Environment;Ethanol;Event;Excision;experience;Experimental Designs;experimental study;Fc Receptor;Fellowship;fly;Future;Gene Expression;Genes;Genetic;genetic approach;genetic manipulation;Genome;Genome engineering;Goals;Head;Human;Image;In Vitro;Individual;Institution;Intoxication;knock-down;Locomotion;Mammals;Measures;Memory;memory encoding;memory retrieval;Mentors;Modeling;Molecular;Mushroom Bodies;mutant;Nervous System Physiology;neural;neural circuit;neurogenetics;Neurons;neuropsychiatric disorder;Neurosciences;Odors;Oral;Output;Pathology;Pattern;Phenotype;Positioning Attribute;Post-Translational Modification Site;Post-Translational Protein Processing;postsynaptic;preference;presynaptic;prevent;programs;Property;Protein Isoforms;protein protein interaction;Proteins;receptor;receptor function;Receptor Gene;Relapse;response;Retrieval;Rewards;RNA Processing;RNA Splicing;Rodent;Role;Sensory;Serine;Sucrose;sugar;superresolution imaging;Technical Expertise;temporal measurement;Testing;Tissues;Training;Transcript;two-photon;Universities;Variant;Ventral Tegmental Area;Work;Writing

PROJECT_TITLE: Alcohol-Induced Alternative Splicing in Drosophila Memory Circuits


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Liver Disease;Nanotechnology;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative In spite of the major success of immune checkpoint inhibitory (ICI) antibodies capable of triggering immune responses to solid cancers, pancreatic ductal adenocarcinoma (PDAC) responds poorly to this intervention due to an immune depleted or “cold” tumor microenvironment. In this application, we will develop a series of nanocarriers to deliver chemotherapeutic drugs to induce “immunogenic cell death” (ICD), which is capable of creating a “hot” tumor environment that can be further exploited to obtain a sustained immune response. The cornerstone of the PDAC immunotherapy platform is a silicasome nanocarrier, which has the ability to deliver ICD stimuli in combination with synergistic small molecule inhibitors that interfere in local immune suppressive pathways.

PI_NAMEs: NEL, ANDRE ELIAS (contact);ZINK, JEFFREY I

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Adjuvant;Adoptive Transfer;Agonist;alternative treatment;Antibodies;Antigen-Presenting Cells;Blocking Antibodies;C-terminal;cancer cell;cancer immunotherapy;cancer site;Cell Death Induction;Cells;checkpoint receptors;chemotherapeutic agent;chemotherapy;Cholesterol;Combination immunotherapy;Custom;CXCR4 gene;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;design;Desmoplastic;Development;Dinucleoside Phosphates;Drug Combinations;Drug Delivery Systems;Duct (organ) structure;Encapsulated;Environment;Exclusion;experimental study;Failure;Gene Delivery;Generations;Genetic Engineering;Genetic Transcription;Glycogen Synthase Kinase 3;Glycolates;Goals;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immuno-Chemotherapy;immunogenic cell death;immunogenicity;immunological status;Immunologics;Immunosuppression;Immunotherapy;improved;inhibitor;Innate Immune System;innovation;Integrin alphaVbeta3;Integrins;Intervention;irinotecan;Lipid Bilayers;Lipids;Liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Memory;Metabolic Pathway;metastasis prevention;Metastatic Adenocarcinoma;Metastatic Neoplasm to the Liver;migration;mortality;Myeloid Cells;Myeloid-derived suppressor cells;nano;nanocarrier;nanoparticle;nanoparticle delivery;nanopolymer;neoantigens;Neoplasm Metastasis;Neuropilin-1;novel strategies;Organ;Outcome Study;overexpression;oxaliplatin;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;PD-1 pathway;PD-1/PD-L1;PDL1 pathway;Penetration;Peptides;Periodicity;Pharmaceutical Preparations;Pharmacologic Substance;prevent;Primary Neoplasm;Prodrugs;programmed cell death protein 1;programs;receptor;recruit;Research;Resistance;response;Role;Science;Series;side effect;Silicon Dioxide;Site;small molecule inhibitor;Solid;Stimulator of Interferon Genes;Stimulus;Stromal Cell-Derived Factor 1;success;synergism;T cell response;T memory cell;T-Lymphocyte;targeted delivery;Techniques;Testing;Therapeutic;Time;transcytosis;treatment strategy;Tryptophan 2,3 Dioxygenase;tumor;Tumor Antigens;tumor microenvironment;Tumor-associated macrophages;uptake;Vaccination

PROJECT_TITLE: Use of a Nano-Enabled Platform for Pancreatic Cancer Immunotherapy


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Rare Diseases;Rehabilitation

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative This project seeks to 1) identify articulation-based dysarthria subgroups derived from articulatory performance profiles of talkers with a variety of underlying neurological conditions using a taxonomic (data-driven) classification approach, 2) determine the articulatory performance characteristics that uniquely differentiate these subgroups, 3) determine if the disease type varies systematically across the identified articulation-based subgroups, and 4) determine the extent to which auditory- and visual-perceptual judgements of articulatory performance map onto the findings of speech kinematic measures. The proposed project is highly relevant to public health and the mission of NIH and NIDCD because it aims to advance our understanding of articulatory impairment patterns and how they may vary across talkers with dysarthria. New discoveries from this project will set the stage for future research efforts that aim to elucidate the subgroup-specific articulatory mechanisms that underlie speech intelligibility loss and recovery in these talkers and facilitate personalized dysarthria management and the development of new, impairment-specific intervention strategies.

PI_NAMEs: MEFFERD, ANTJE  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Affect;Age;Amyotrophic Lateral Sclerosis;Articulation;Auditory;Behavior;Behavior Therapy;career;Characteristics;Classification;Clinic;Clinical;clinical practice;Cluster Analysis;cohort;Control Groups;Coupling;Cueing for speech;Data;design;Development;Disease;disorder subtype;Dysarthria;Ensure;Exhibits;feasibility testing;Goals;Grain;Huntington Disease;Hypokinesia;Impairment;impression;improved;Infrastructure;Intervention;Jaw;kinematics;Knowledge;Link;Lip structure;Loudness;Maps;Measures;Mission;Mixed Dysarthrias;Motor;motor impairment;Movement;Multiple Sclerosis;National Institute on Deafness and Other Communication Disorders;Neurodegenerative Disorders;Neurologic;Outcome;Outcome Study;Parkinson Disease;Pattern;Performance;Positioning Attribute;Posture;Public Health;Reading;Recommendation;Recovery;Reporting;Research;sex;Social isolation;Speech;Speech Intelligibility;Subgroup;System;Taxonomy;Textbooks;Therapeutic Intervention;Tongue;Translations;United States National Institutes of Health;Video Recording;virtual;Visual;Work

PROJECT_TITLE: A taxonomic articulation-focused approach to dysarthria classification

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Disability Research;Hearing Loss;Mental Health;Neurodegenerative;Neurosciences;Prevention;Rehabilitation

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Hearing loss is a risk factor for Alzheimer’s disease (AD) and other forms of cognitive impairment in humans. In mice, hearing loss causes cognitive impairment reflecting hippocampal dysfunction. We will use a mouse model of AD to disambiguate whether hearing loss specifically accelerates key AD pathologies such as accumulated amyloid β plaques and hyperphosphorylated tau, and to determine whether neuronal activity patterns in the hippocampal network are disrupted by hearing loss, to provide insight into the mechanisms through which hearing loss causes cognitive impairment.

PI_NAMEs: BIGELOW, JAMES  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: abeta accumulation;Ablation;Acceleration;Address;Adult women;Affect;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Animal Model;Animals;apolipoprotein E-4;Area;arm;attenuation;Auditory;Auditory area;auditory pathway;Behavioral;Biochemical;Brain;Chronic;Clinical;Cochlea;Cochlear Hearing Loss;Communication difficulty;comorbidity;Compensation;Dementia;dementia risk;Development;disability;Disease;Disease Progression;Education;entorhinal cortex;Epidemic;Epidemiology;epidemiology study;Etiology;familial Alzheimer disease;Functional disorder;Genes;Genetic;hearing impairment;hearing loss treatment;Heterozygote;Hippocampus;Histologic;Hormones;Human;Hyperactivity;hyperphosphorylated tau;Impaired cognition;Impairment;Implant;Individual;insight;Intervention;Learning;Link;male;Memory;Memory impairment;Mental Depression;Metabolic;Metabolic dysfunction;modifiable risk;Monitor;mouse model;Mus;Mutation;neural;Neurofibrillary Tangles;Neurons;neurophysiology;Noise;noise exposure;Outcome;oxidation;Pathology;Pattern;Performance;pharmacologic;Phenotype;Physiological;Physiology;Population;prevent;Prevention;Psychosocial Factor;Public Health;Radial;Rattus;response;Risk Factors;risk mitigation;risk sharing;Rodent;Role;Senile Plaques;Severities;sex;side effect;social;Social isolation;sound;spatial memory;Stress;Symptoms;tau-1;Testing;therapeutic target;Time;timeline;Tissues;treatment strategy;Withdrawal

PROJECT_TITLE: The role of hearing loss in cognitive impairment and Alzheimer’s disease pathology


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: POMONA

ORG_DEPT: BIOLOGY

ORG_NAME: CALIFORNIA STATE POLY U POMONA

PHR: PROJECT NARRATIVE: Acquired mutations in cancers, including liquid cancers such as leukemia, can lead to drug resistance in cancer cells. The proposed studies in this proposal will seek to investigate how chromosome rearrangement between Daple and tyrosine kinase receptors lead to leukemias, and the tools that will be generated may offer a new modality to target such mutations. Insights gained through the proposed studies will provide a mechanistic insight into the Daple-Kinase gene fusion and to establish zebrafish as a rapid and personalized disease model for therapeutic testing.

PI_NAMEs: EAR, JASON  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Address;Affect;Award;BAY 54-9085;Biochemical;Biological Assay;biological research;Blood Vessels;cancer cell;cancer therapy;career;Cell Count;cell growth;Cell Line;Cells;Centrosome;Chromosomal Rearrangement;Chromosomes;Coiled-Coil Domain;Combined Modality Therapy;Cultured Cells;Dimerization;disease model;Dominant-Negative Mutation;dosage;Drug resistance;Embryo;embryo tissue;Embryonic Development;Exposure to;FLT3 gene;fluorescence imaging;Fluorescence Resonance Energy Transfer;Gene Activation;Gene Fusion;gene product;Genes;GTP-Binding Proteins;Health;Hematopoietic;Hematopoietic Neoplasms;Heterotrimeric GTP-Binding Proteins;Homeostasis;Human;Imatinib;In Vitro;in vivo Model;inhibitor therapy;insight;Lead;leukemia;Leukemic Cell;Life;Ligand Binding Domain;Liquid substance;Lymphocyte;Lymphoma cell;Malignant Neoplasms;MAPK3 gene;MEKs;Messenger RNA;Microscopy;Modality;Modeling;Molecular;Monitor;Mus;mutant;Mutation;Myeloproliferative disease;Nature;new therapeutic target;novel;novel therapeutics;Oncogenic;Organism;overexpression;Pathway interactions;patient response;patient subsets;Patients;PDGFRB gene;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Play;Population;protein oligomer;protein protein interaction;Proteins;Proto-Oncogene Proteins c-akt;Ras/Raf;receptor;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Regulation;Resistance;response;Role;Scaffolding Protein;side effect;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;Signaling Protein;Solid Neoplasm;Students;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic protein;Time;tool;Training;transcriptomics;tumor;tumor progression;Tyrosine Kinase Domain;Tyrosine Kinase Inhibitor;Up-Regulation;Western Blotting;WNT Signaling Pathway;Work;Zebrafish

PROJECT_TITLE: Elucidating the molecular mechanism of Daple- FLT3 and Daple-PDGFRB gene fusion in blood cancers


ADMINISTERING_IC: DK

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: MADISON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Obesity and its related metabolic disorders are at historic prevalence throughout the world. There is no reliable way to predict what diet is ideal for metabolic health on an individual basis. This project will explore the role of genetic variation in the response to two popular diets (high-fat/low-carb, vs. low-fat/high-carb) in a genetically diverse mouse population and discover the genes and pathways that mediate diet responsiveness.

PI_NAMEs: ATTIE, ALAN D (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Adipose tissue;Affect;American Heart Association;Animal Model;Automobile Driving;Biological Markers;Biological Models;blood lipid;Body Weight;Candidate Disease Gene;Carbohydrate Metabolism Pathway;Carbohydrates;cardiometabolism;Chromosome Mapping;Clinical;Clinical Markers;Clinical Research;Consensus;Data;density;Diet;Diet Research;dietary;Dietary Intervention;Distal;Eating;experimental study;Fatty acid glycerol esters;gene discovery;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic architecture;Genetic Determinism;Genetic Markers;Genetic Screening;Genetic study;genetic variant;Genetic Variation;genome wide association study;genomic locus;Genomic Segment;Genotype;glucose tolerance;Goals;gut microbiome;gut microbiota;Health;Human;human model;Inbred Strains Mice;Individual;Individual Differences;Insulin Resistance;insulin secretion;insulin sensitivity;interest;Intestines;Isotope Labeling;ketogentic;lean body mass;Link;lipid metabolism;Lipids;Lipoproteins;Liver;Mammals;Maps;Mass Spectrum Analysis;Measurement;Measures;Mediating;Mediation;Mediator;Metabolic;Metabolic Control;Metabolic Diseases;Metabolic Marker;Metabolic Pathway;Metabolism;metagenomic sequencing;microbiome;model organism;Modeling;Molecular;molecular marker;molecular phenotype;mouse model;Mouse Strains;Mus;Muscle;Nutrient;Obesity;Outcome;Pathway interactions;personalized medicine;Persons;Phenotype;Physiological;Physiology;Plasma;Play;Population;predictive marker;Prevalence;Production;protein metabolism;Quantitative Trait Loci;Recommendation;Research;Resolution;response;Role;Skeletal Muscle;Small Intestines;SNP array;stable isotope;Synteny;Testing;Time;Tissues;Tracer;trait;Translating;Validation;Weight Gain;whole genome

PROJECT_TITLE: Genetic Control of Metabolic Flux in Response to Diet


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Age-related macular degeneration is the leading cause of blindness in the elderly in the US and is a significant public health issue that is projected to worsen due to the rapidly aging population. Here we aim to understand how retinal cells change in normal aging and how these normal age-related changes differ from the changes that lead to age-related macular degeneration. This project will allow us to detect age-related macular degeneration earlier and will produce new tools to monitor retinal cells that will facilitate the development and testing of preventative therapies to slow or prevent vision loss in age-related macular degeneration.

PI_NAMEs: ROSSI, ETHAN A (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: adaptive optics;Age;age related changes;Age related macular degeneration;Aging;aging population;aging related;Area;Atrophic;Biological Markers;Blindness;Bruch's basal membrane structure;Case/Control Studies;Cells;Cessation of life;Choroid;Classification;Clinical;clinical decision-making;clinical diagnosis;clinical imaging;cohort;Complex;Correlation Studies;Cross-Sectional Studies;Cytoplasmic Granules;Data;Data Set;Detection;Development;Diagnostic Procedure;Disease;Drusen;early onset;Elderly;Evaluation;Eye;fluorophore;Foundations;Genetic;Goals;Health;healthy aging;Histology;Histopathology;Human;Image;Image Analysis;imaging modality;imaging platform;improved;in vivo;Individual;Knowledge;Lipofuscin;Machine Learning;macula;Maps;Melanins;Methods;Microscopic;Modeling;Monitor;morphometry;multimodality;neurovascular unit;nonhuman primate;normal aging;Ophthalmoscopy;Optical Coherence Tomography;Optics;Perfusion;Phenotype;Photoreceptors;Prevalence;prevent;Preventive therapy;Preventive treatment;Primates;Public Health;Research;restorative treatment;Retina;Retinal Cone;Retinal Degeneration;retinal imaging;Retinal Photoreceptors;Risk;Secondary to;Spatial Distribution;Structure;Structure of retinal pigment epithelium;System;Techniques;Technology;Testing;therapy design;Therapy Evaluation;Time;Tissues;tool;Variant;Vertebrate Photoreceptors;Vision;Work

PROJECT_TITLE: Distinguishing normal aging from age-related macular degeneration at the level of single cells in the living human eye

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Immunotherapy;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Traumatic injuries from burns, blasts, or major surgery disrupts normal immune system functions, which can lead to the development of life-threatening infections and prolonged critical illnesses. Targeted immunotherapies for traumatic injuries to restore immune system function have not yet been developed and are urgently needed. This project studies the scientific processes involved in using specific natural immunostimulatory DNA as a novel treatment approach to enhance immune system health in immune compromised trauma patients that are at risk of dying from complications of their injuries.

PI_NAMEs: LEDERER, JAMES A. (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;Affect;Agonist;antimicrobial;Bacterial DNA;Binding Sites;Biological Assay;Blood;Bone Marrow;Bone Marrow Involvement;Burn injury;Burn Trauma;Catalogs;cell injury;Cell Reprogramming;Cells;Chimera organism;Cleavage Under Targets and Release Using Nuclease;Critical Illness;cytokine;Cytometry;Development;DNA;DNA Sequence;donor stem cell;Effector Cell;Emergency Situation;Epigenetic Process;Eukaryotic Cell;Flow Cytometry;Gene Expression Profiling;Genetic Transcription;germ free condition;Granulopoiesis;Hematopoietic;hematopoietic stem cell differentiation;hematopoietic stem cell niche;Hematopoietic stem cells;Histones;Homeostasis;Human;Immune;immune health;Immune response;Immune system;immune system function;Immunity;Immunologics;Immunology;Immunophenotyping;immunoregulation;Immunotherapeutic agent;Immunotherapy;In Vitro;Infection;injured;Injury;injury recovery;insight;Life;Lung;Mediating;medical countermeasure;mesenchymal stromal cell;Methodology;Mitochondria;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;novel;Operative Surgical Procedures;Opportunistic Infections;organ injury;Peripheral;Persons;Phenotype;Population;pre-clinical;Process;programs;Proteomics;Proto-Oncogene Protein c-kit;Radiation Injuries;Reaction;Recovery;Regulator Genes;Research;response;Risk;Role;Signal Transduction;Solid;Sorting;targeted treatment;Testing;therapeutic DNA;Therapeutic Intervention;Time;TLR9 gene;Training;trait;transcription factor;transcriptome sequencing;Translating;Trauma;Trauma patient;Traumatic injury;treatment effect

PROJECT_TITLE: Targeting Trained Immunity in Trauma-Induced Immune Dysregulation

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dementia;Depression;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care;Sleep Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The proposed research will promote the public health of more than 15 million Americans who serve as family caregivers for relatives with Alzheimer’s disease and related dementias. It will assess whether stress reduction therapy incorporating guided imagery practices that promote perspective taking and empathy can improve the effects of family caregiver skills training delivered remotely by smartphone. It will also test the feasibility of using smartphone estimated markers to track caregiver insomnia and stress, which could eventually help reduce caregiver suffering and healthcare costs by identifying early warning signs of treatment failure and symptomatic worsening.

PI_NAMEs: JAIN, FELIPE A. (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Accounting;adaptive intervention;Adult;Affect;Age;Age Years;Aging;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapy;American;Area;Attention;Award;Behavior;Behavioral;behavioral phenotyping;Brain;care giving burden;care recipients;Caregiver Burden;caregiver depression;Caregiver research;caregiver stress;Caregivers;caregiving;Caring;Cellular Phone;Chronic stress;clinical effect;Data;Data Science;Dementia;Dementia caregivers;depressive symptoms;Development;digital;digital phenotyping;Early identification;Ecological momentary assessment;Emotional;Emotional Stress;Empathy;exhaustion;Exhibits;Face;Family;Family Caregiver;Family member;Feasibility Studies;feasibility testing;follow-up;Friends;Guided imagery;Health Care Costs;high risk;Imagery;improved;improvement on sleep;Individual;Institutionalization;Intervention;K-Series Research Career Programs;Lead;Link;loved ones;Machine Learning;Measurement;Measures;Mediating;medical schools;Mental Depression;Mental Health;mentalization;Mentors;Methods;Mind;mindfulness;Mindfulness Training;mobile application;mobile delivery;Modeling;Monitor;Moods;multimodality;National Institute on Aging;Nature;negative mood;novel therapeutics;older adult;Outcome;Outcome Assessment;Participant;Patient Self-Report;Patients;perceived stress;perspective taking;physical conditioning;Population;predict clinical outcome;Prefrontal Cortex;Preparation;primary outcome;Psychiatrist;psychologic;psychological symptom;Public Health;Publishing;Randomized, Controlled Trials;remote delivery;Reporting;Research;Research Personnel;Research Support;Research Training;Risk;Role;Schizophrenia;secondary outcome;Self Care;sensor;skills;skills training;Sleep;Sleep disturbances;Sleeplessness;smartphone application;social;Social Environment;Strategic Planning;Stress;stress reduction;Symptoms;Testing;Time;tool;Training;Transact;Treatment Failure;Treatment outcome;treatment response;Universities;Washington;Work;young adult

PROJECT_TITLE: Mobile app delivered Mentalizing Imagery Therapy to augment remote family dementia caregiver skills training: a pilot randomized, controlled trial with outcomes assessment using digital phenotyping


ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Mechanisms of Endogenous DNA Damage Promotion This project leverages Escherichia coli as a tractable, proven cancer model for discovery of functions and consequences of a large, diverse, conserved network of proteins that promote DNA damage and genome instability, with the goal of modeling functions of large numbers of cancer proteins currently poorly understood. The DNA damage-up proteins (DDPs) were discovered in E. coli, their human homologs shown to be cancer predictive, and also to promote DNA damage and mutation. This project uses the E. coli model to uncover both mechanisms that generate spontaneous endogenous DNA damage, and the functions and mechanisms of DNA-damage promotion by bacterial and human DDPs, to understand how many cancer-promoting proteins drive cancers, which may potentially enable universal, economical cancer/disease screening, and novel anti-cancer drug targets.

PI_NAMEs: MILLER, KYLE M;ROSENBERG, SUSAN M (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Alzheimer's Disease;anti-cancer;Automobile Driving;Bacterial DNA;Biological Markers;Biological Process;cancer biomarkers;Cancer Diagnostics;Cancer Etiology;Cancer Model;cancer prevention;Cells;Closure by clamp;cost;Data;Defect;Diagnosis;Diagnostic;Disease;Disease susceptibility;DNA;DNA Binding;DNA Damage;DNA Methylation;DNA Modification Methylases;DNA Repair;DNA Repair Gene;DNA replication fork;DNA Sequence Alteration;DNA Structure;Drug Targeting;Equilibrium;Escherichia coli;Event;experimental study;gain of function;Genes;Genome;genome sequencing;genome-wide;Genomic Instability;Goals;Heat shock proteins;Homologous Gene;Human;Human Cloning;human DNA;human DNA damage;human model;inhibitor;innovation;insight;Link;loss of function;loss of function mutation;Malignant Neoplasms;Maps;Methylation;Mismatch Repair;Modeling;Molecular;Mutagenesis;Mutation;neural;novel anticancer drug;Oncogenes;Oncogenic;Oncoproteins;Output;Pathology;Patient-Focused Outcomes;Pharmaceutical Preparations;Phenotype;predictive modeling;Production;protein function;Proteins;Reagent;RNA;Role;Route;Sampling;screening;Signal Transduction;Single-Stranded DNA;success;synthetic construct;Testing;Therapeutic;transcription factor;transcriptome;translation to humans;Translations;tumor;whole genome;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Q(02)M]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Cocaine;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: SOCIAL SCIENCES

PHR: Project Narrative Substance use disorders (SUDs) are highly prevalent among formerly incarcerated individuals, and drug overdose rates are elevated post-incarceration. The proposed research represents an opportunity to identify individual and environmental-level predictors of opioid and/or cocaine use over a one-year period among formerly incarcerated individuals, and to determine whether they are receiving adequate levels of addiction treatment. The proposed research will identify substance use treatment gaps and influential factors that are amenable to intervention in the interest of informing effective responses to problematic substance use.

PI_NAMEs: ROWELL-CUNSOLO, TAWANDRA LASHONE (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: addiction;Address;adverse outcome;American;Area;Caring;Characteristics;Cocaine;cocaine use;Cocaine Users;Communities;Criminal Justice;Data;Diagnosis;Drug usage;Environment;Environmental Risk Factor;experience;Exposure to;Frequencies;Gender;General Population;Health Services Accessibility;Heroin Users;high risk;high risk behavior;Home;Hospitalization;Illicit Drugs;illicit opioid;Imprisonment;Income;Individual;Influentials;Institution;interest;Intervention;Measures;Medicine;Mental Health;mortality risk;multilevel analysis;Neighborhoods;New York;New York City;novel;Opioid;opioid overdose;opioid use;opioid user;Overdose;overdose risk;parole;Participant;Pathway interactions;Patients;people of color;Pharmaceutical Preparations;poor communities;Population;probation;Race;Recommendation;Reporting;Research;Residential Mobility;Resources;response;Risk;Risk Factors;Severities;Site;social;Societies;substance use;Substance Use Disorder;substance use treatment;Supervision;theories;Time;time use;transitional housing;Treatment Effectiveness;treatment services;United States

PROJECT_TITLE: Examining predictors of substance use and treatment adequacy among formerly incarcerated opiod and cocaine users

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


PHR: Iron balance in the body must be closely controlled to provide this essential nutrient for red blood cell production, but to prevent the damaging effects of too much iron on a number of organs including the liver, heart, and pancreas. This proposal will investigate how the liver senses iron levels in the body to control production of a hormone called hepcidin that is critical to keep body iron in balance. Our work will help to understand how iron balance is disrupted in diseases of too little or too much iron including anemia, hemochromatosis, and b- thalassemia, with the ultimate goal to identify new ways to treat these diseases.

PI_NAMEs: BABITT, JODIE L (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Affect;Anemia;Anemia due to Chronic Disorder;Animal Model;beta Thalassemia;Binding;Binding Sites;Biological Assay;Biology;BMP6 gene;Bone Morphogenetic Proteins;Cell Culture Techniques;ChIP-seq;chromatin immunoprecipitation;Chronic Disease;Clinical Trials;Communication;conditional knockout;Data;Databases;Diet;Disease;Endothelial Cells;Endothelium;Equilibrium;Erythrocytes;Erythropoiesis;Ferritin;Functional disorder;Funding;Genetic;Genetic Transcription;Goals;Health;Heart;Hemochromatosis;Hepatocyte;hepcidin;Hereditary Disease;Hereditary hemochromatosis;HFE2 gene;Homeostasis;Hormones;Human;Hypoxia Inducible Factor;improved;In Vitro;in vivo;inhibitor;insight;Iron;iron absorption;iron deficiency;Iron Metabolism Disorders;Iron Overload;jun Oncogene;Kinetics;knock-down;Knock-out;Knockout Mice;Ligands;Liver;Macrophage;Mediating;Messenger RNA;metal transporting protein 1;Modeling;Molecular;mouse model;Mus;novel therapeutic intervention;novel therapeutics;Nucleic Acid Regulatory Sequences;Nutrient;Organ;overexpression;Oxidative Stress;Pancreas;Pathway interactions;Persons;pharmacologic;Physiology;Play;prevent;Production;Proteomics;Publishing;Reactive Oxygen Species;receptor;Regulation;Regulatory Pathway;Reporter;response;Role;Signal Pathway;Signal Transduction;Signaling Protein;Site-Directed Mutagenesis;Smad Proteins;Source;Testing;TFRC gene;Thalassemia;therapeutic target;Tissues;Toxic effect;transcription factor;transcriptome sequencing;Transferrin;uptake;validation studies;Work

PROJECT_TITLE: Regulation of Iron Homeostasis by BMP Signaling

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Adolescent alcohol use, particularly during early adolescence, is a risk factor for excessive alcohol use in adulthood; however, neuronal changes underlying increased alcohol use have not been fully characterized. This project will use cutting-edge techniques to investigate the function of a particular neuronal population and its role in increased adulthood drinking following adolescent alcohol exposure.

PI_NAMEs: SICHER, AVERY  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Adolescence;Adolescent;adolescent alcohol effect;adolescent alcohol exposure;adolescent alcohol misuse;adolescent binge drinking;Adult;Affect;Age;Agonist;Alcohol abuse;Alcohol consumption;alcohol content;Alcohol dependence;alcohol effect;alcohol exposure;alcohol risk;alcohol use disorder;Alcohols;Animal Model;Animals;Behavioral;binge drinking;Blood;Calcium Signaling;Cells;Closure by clamp;Clozapine;Consumption;Darkness;designer receptors exclusively activated by designer drugs;Development;drinking;early adolescence;effective intervention;Electrophysiology (science);experimental study;Fiber;genetic manipulation;Goals;Heavy Drinking;in vivo;Intervention;Life;Link;Modeling;Mus;neuroadaptation;neuronal excitability;Neurons;neuropsychiatry;Oxides;patch clamp;Pattern;Pharmacological Treatment;Photometry;Population;Public Health;Reporting;Risk;Risk Factors;Role;Somatostatin;Substance Use Disorder;Synapses;Techniques;therapeutic target;underage drinking;Virus;voltage clamp;Vulnerable Populations

PROJECT_TITLE: Investigating the effects of adolescent binge drinking on prelimbic somatostatin circuitry


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: NARRATIVE The proposed research aims to understand how the EPHA2 cell surface receptor integrates both mechanical and biochemical cues from the tumor microenvironment to regulate tumor progression and metastasis via its canonical and non-canonical signaling mechanisms in cancer cells. Results from this research could lead to new approaches to inhibit tumor metastasis.

PI_NAMEs: PASQUALE, ELENA B (contact);YANG, JING

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Affect;Binding;Biochemical;Biological Assay;Breast Cancer Cell;Breast Cancer Model;breast cancer progression;cancer cell;cancer invasiveness;Cell membrane;Cell Surface Receptors;Consensus;CSNK1A1 gene;Cues;Cyclic AMP-Dependent Protein Kinases;EPHA2 gene;EphA2 Receptor;Ephrins;Epithelium;extracellular;Extracellular Matrix;in vivo;Invaded;Ligand Binding;Ligand Binding Domain;Ligands;LYN gene;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Mammary Neoplasms;mechanical force;mechanical signal;Mechanics;mechanotransduction;Mesenchymal;Molecular;Mus;Neoplasm Metastasis;neoplastic cell;novel strategies;Nuclear;Organoids;Pathway interactions;Peptides;Phosphorylation;Phosphorylation Inhibition;Phosphorylation Site;Phosphotransferases;Play;Protein-Serine-Threonine Kinases;Proto-Oncogene Proteins c-akt;Receptor Signaling;recruit;Research;response;Role;Serine;Serine/Threonine Phosphorylation;Signal Induction;Signal Pathway;Signal Transduction;src-Family Kinases;three dimensional cell culture;Threonine Phosphorylation Site;transcription factor;tumor;Tumor Cell Invasion;tumor microenvironment;tumor progression;Tumor Promotion;TWIST1 gene;Tyrosine;Tyrosine Phosphorylation Site;Work;Xenograft Model

PROJECT_TITLE: EPHA2 Receptor Signaling in Breast Cancer Mechanotransduction

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE INST FOR BIOMEDICAL/CLINICAL RES

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed research relates to type 2 diabetes (T2D), which is a major public health challenge due to its increased prevalence worldwide. Specifically, the studies address deficits in both pancreatic β-cell function and mass in T2D by interrogating the therapeutic potential of a novel metabolite of the renin-angiotensin system, namely angiotensin(1-2). By using cell-based and whole-body models, it is expected that the proposed studies will reveal previously unrecognized intracellular mechanisms of action for angiotensin(1-2) that impact glycemic control, and could be exploited in the pursuit of new drugs that target several abnormalities in T2D.

PI_NAMEs: ZRAIKA, SAKENEH  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: active method;Address;Adolescent;Adult;age related;Anabolism;Angiotensins;Anti-diabetic Drugs;Apoptosis;Beta Cell;Binding;blood glucose regulation;Cell Death;Cell Physiology;Cell Proliferation;cell regeneration;Cell Survival;Cells;Clinical Management;CRISPR/Cas technology;Data;Deterioration;Development;diabetic;Diabetic mouse;Dipeptides;Diphtheria Toxin;Exposure to;Failure;Future;gain of function;Genetic Transcription;GLP-I receptor;Glucagon;glucagon-like peptide 1;Glucose;glycemic control;Goals;GPRC6A gene;Human;Hydrolysis;improved;In Vitro;in vivo;Inhibition of Apoptosis;inhibitor;innovation;Insulin;insulin secretion;Investigation;islet;Islets of Langerhans Transplantation;Knock-out;loss of function;Mediating;Modeling;Mus;Mutagenesis;Natural regeneration;new therapeutic target;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Output;paracrine;Paracrine Communication;Pharmaceutical Preparations;phosphoproteomics;preservation;Prevalence;prevent;Production;proglucagon;Proliferating;Property;protective effect;Proteins;Public Health;Renin-Angiotensin System;Research;Resistance;Role;Signal Pathway;Signal Transduction;Structure of beta Cell of islet;targeted treatment;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Time;transplant model;Withdrawal;Youth

PROJECT_TITLE: Role of the Renin-Angiotensin System in Glucose Homeostasis

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: The interaction between prefrontal and visual cortical areas is critical for many cognitive functions including attention and working memory. This proposal investigates the role of phase coding in visual cortex, along with its modulation by prefrontal activity during working memory, and the ability of a similar coding mechanism to expand the information capacity of the visual system during eye movements. Understanding the role of phase coding during working memory and eye movements will provide a necessary comparison point for neurological disorders involving impaired prefrontal-sensory interactions, including schizophrenia, Alzheimer’s disease, attention deficit hyperactivity disorder, and autism spectrum disorders.

PI_NAMEs: NOUDOOST, BEHRAD  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Action Potentials;Address;Alzheimer's Disease;Area;area MT;area V4;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;behavior influence;Brain;Code;Cognitive;cognitive function;Communication;Coupled;Coupling;design;Electrodes;Event;experimental study;extrastriate;extrastriate visual cortex;Eye Movements;Frequencies;frontal eye fields;Funding;Goals;Impairment;Link;Maintenance;Measures;Mediating;Memory;Nature;Nervous System Disorder;neural;neural correlate;Neurons;nonhuman primate;Pattern;Periodicity;pharmacologic;Phase;Play;Population;Prefrontal Cortex;Property;rate of change;receptive field;recruit;Reporting;Research;response;Role;Saccades;Schizophrenia;Sensory;Short-Term Memory;Signal Transduction;Source;Stimulus;Testing;theories;Time;Visual;Visual Cortex;Visual Fields;visual information;Visual Perception;Visual System

PROJECT_TITLE: Prefrontal contributions to phase-dependent representation of visual information

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This application is relevant to human health as it introduces new methods to produce medicinally relevant mol- ecules with electrical energy. Electrosynthesis under optimum conditions is operationally simple, environmen- tally friendly, and highly scalable, as it eliminates expensive chemical reagents, produces less waste, and re- duces synthetic steps.

PI_NAMEs: ZHANG, SHIYU  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Electrically Driven C-H Functionalization with CuII/CuIII Redox Catalysts

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative With knowledge of the genes that contribute to resistance against infectious diseases, researchers, medical professionals, and epidemiologists can better estimate the risk that individuals and populations face from a particular infection, predict the spread of an infectious disease, and develop gene-based therapies. The proposed work will tackle a central challenge in identifying these genes: their effects seem to depend strongly on context, with many genes contributing to parasite resistance in only one of many environments or against only one of many parasite strains. I take advantage of new resources for studying natural populations of a biomedical model organism, Caenorhabditis elegans, and its natural parasites to advance our general understanding of how, and why, genetic and environmental contexts change the loci that promote resistance against infection.

PI_NAMEs: GIBSON, AMANDA K (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Alleles;Biological Models;Biomedical Research;Caenorhabditis elegans;Collection;Communicable Diseases;Data;Dependence;Diet;Disease susceptibility;Environment;Epidemiologist;Evolution;experimental study;Face;Foundations;gene therapy;Genes;Genetic;genetic approach;genetic variant;Genetic Variation;genome wide association study;Genomics;Genotype;Goals;Health;Human;Inbreeding;Individual;Infection;Infectious Diseases Research;Knowledge;Maps;Medical;microbial;Microsporidia;model organism;Molecular;Nature;Nematoda;Organism;Parasite resistance;Parasites;Parents;Phenotype;Population;Population Density;Positioning Attribute;Predisposition;programs;Recombinants;Research;Research Personnel;Resistance;resistance allele;Resolution;Resources;Risk Estimate;Sampling;Surveys;Testing;trait;Transgenic Organisms;Variant;Work

PROJECT_TITLE: A general test of the genetic basis of parasite resistance across genetic and environmental contexts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Physical Activity;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Heavy alcohol drinking during adolescence is known to disturb brain development and functioning and increase risk of drinking problems in adulthood, but the extent of the lingering effects of youthful drinking on adult functioning remains unclear. The goal of NCANDA-A (Adulthood) is to follow youth who have and have not engaged in hazardous drinking to determine alcohol's influence on the brain, cognition, emotion, and life activities in emerging adulthood when young men and women are establishing themselves in careers, relationships, and independent living. Recognition of signs of risk to adjustment in adulthood following youthful drinking may enhance opportunity for personal success.

PI_NAMEs: PFEFFERBAUM, ADOLF ;POHL, KILIAN MARIA (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: 21 year old;Abstinence;Acceleration;Adolescence;Adolescent;adolescent binge drinking;Adult;Adverse effects;Affective;Age;Alcohol abuse;Alcohol consumption;alcohol cue;alcohol effect;alcohol expectancy;alcohol use disorder;alcohol use initiation;Alcohols;Behavioral;binge drinking;Biological;Brain;career;Clinical;Clinical assessments;Cognition;Cognitive;cognitive control;cognitive performance;cohort;Collection;Communities;Computers;COVID-19 impact;COVID-19 pandemic effects;cue reactivity;Data;Data Analyses;Data Collection;data integration;data sharing;data standards;design;Development;Distress;Dose;drinking;drinking onset;early onset;Economics;emerging adult;emerging adulthood;Emotional;Emotions;Ensure;Event;experience;externalizing behavior;Family;Female;follow-up;Frequencies;Functional Magnetic Resonance Imaging;Goals;Growth;hazardous drinking;Health;Heavy Drinking;Home;Independent Living;Individual;informatics infrastructure;information processing;Life;Life Stress;Link;Machine Learning;machine learning framework;Magnetic Resonance Imaging;male;Measures;Mediating;medical specialties;Mission;mobile application;Modeling;Monitor;multimodal neuroimaging;neural;neurodevelopment;neuroimaging;neuropsychiatry;Neuropsychology;novel;novel strategies;Outcome;Outcome Measure;pandemic disease;Participant;Pattern;Personal Satisfaction;Persons;Physical activity;Positioning Attribute;post-pandemic;pre-pandemic;predictive marker;Procedures;Process;Protocols documentation;Psychopathology;Psychosocial Factor;Quality Control;Recording of previous events;Recovery;recruit;Resources;response;Rest;retention rate;Risk;Sampling;Schools;Sex Differences;Sex Differentiation;Site;Sleep;social;Standardization;Stress;Structure;success;Symptoms;System;Technology;Testing;underage drinking;Work;young man;young woman;Youth

PROJECT_TITLE: NCANDA: Data Analysis Resource


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative VE-cadherin is a protein on the surface of endothelial cells that work to assemble cells properly into the lining of the vasculature during development, maintain vessel structure and organization in organs, and control the leakiness of blood vessels in many organs. This project will analyze how VE-cadherin and associated proteins control vascular leakiness in normal and inflamed tissues.

PI_NAMEs: GUMBINER, BARRY M. (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Actins;Acute;Acute Respiratory Distress Syndrome;Adherens Junction;Adhesions;Adhesives;Affect;Allosteric Regulation;angiogenesis;Angiopoietins;Biochemical;Biophysics;Blood;Blood Vessels;cadherin 5;Cadherins;CDH5 gene;cell assembly;Cell surface;Cytoskeleton;Development;Disease;Edema;Endocytosis;Endothelial Cells;Endothelium;Environment;Epithelium;Event;experimental study;Hemorrhage;Histamine;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inhibiting antibody;Intercellular Junctions;interest;interstitial;Ischemic Stroke;Leucocytic infiltrate;Leukocytes;Mediating;Microcirculatory Bed;Modeling;Monoclonal Antibodies;Morphogenesis;mouse model;Mus;Neoplasm Metastasis;novel;novel strategies;Organ;Permeability;Phosphorylation;Physiological Processes;prevent;Process;Proteins;Publications;Regulation;response;Role;Route;Sepsis;Signal Transduction;Stream;Structure;Surface;Testing;Therapeutic;Thrombin;TIE-2 Receptor;Tight Junctions;Tissues;tool;tumor;Vascular Endothelial Growth Factors;Vascular Endothelium;vascular factor;Vascular Permeabilities;Work

PROJECT_TITLE: Novel Mechanisms Controlling Endothelial Junctions and Vascular Permeability

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: NARRATIVE The translation of basic research on aging into preventions and therapies requires a deeper understanding of why aging causes disease. The USC/Buck Nathan Shock Center will fund innovative pilot projects, give access to leading edge technologies focused on aging and mentor junior investigators from across the nation to train them to become the next leaders in the field.

PI_NAMEs: COHEN, PINCHAS ;CURRAN, SEAN P;LITHGOW, GORDON J;VERDIN, ERIC M. (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Acceleration;Aging;aging mechanism;Air Pollution;Apoptosis;Basic Science;Bioinformatics;Biological Assay;Biological Models;Biology of Aging;Birth;California;Cell Aging;Cells;Centers of Research Excellence;Chronic Disease;Collaborations;Collection;Communities;Cultured Cells;Data;design;Disease;Doctor of Philosophy;Education;Ensure;Environment;experience;Faculty;Female;Financial Support;Fishes;fly;Funding;Funding Mechanisms;Future;gene interaction;Generations;Genes;Genomics;Geroscience;Geroscientist;Goals;Health;Health and Retirement Study;Human;Human Resources;Infrastructure;innovation;Institution;Intervention;Joints;late life;Leadership;life span;Medicine;Mentors;Mentorship;Metabolism;Methodology;Methods;Methylation;Mitochondria;model organism;Modeling;Mus;Nature;next generation;Organ;Organism;Organoids;phenomenological models;Phenotype;Pilot Projects;Prevention;programs;reproductive senescence;Research;research and development;Research Infrastructure;Research Institute;Research Personnel;Resources;sabbatical;Sampling;Scanning;Scheme;senescence;Shock;single cell analysis;single cell technology;Technology;technology platform;therapy development;Tissues;Training;training opportunity;translational genomics;Translations;United States National Institutes of Health;Universities;verdin photosensitizer;voucher;Yeasts

PROJECT_TITLE: The University of Southern California and Buck Institute Nathan Shock Center


NIH_SPENDING_CATS: Aging

PI_NAMEs: ANDERSEN, JULIE KAY (contact)

PROJECT_TERMS: Address;African;Aging;Award;biogerontology;Biology of Aging;Budgets;Caenorhabditis elegans;California;career;career development;Cell Culture Techniques;collaborative approach;Commercial Sectors;Country;Data;design;Development;Drosophila genus;Effectiveness;Environment;Faculty;Fostering;Funding;Generations;Gerontology;Geroscience;Geroscientist;Goals;Grant;Human;innovation;Institution;Killifishes;Lead;Leadership;Learning;Mammalian Cell;Mentors;model organism;Modeling;next generation;novel;Participant;Pilot Projects;Postdoctoral Fellow;pro-aging;programs;recruit;Research;research and development;Research Personnel;Research Support;Resources;sabbatical;Scheme;Schools;Science;Scientist;Secure;Shock;Structure;synergism;Talents;Techniques;Technology;technology platform;Time;Training;Training and Education;United States;Universities;voucher;Work

PROJECT_TITLE: Research Development Core


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: RELEVANCE Under chronic blood pressure as in hypertension, the heart muscle compensates by a variety of ways that result in thickening and enlargement of heart muscle wall or hypertrophy. Left ventricular hypertrophy in hypertensive patients is a strong predictor of heart failure and mortality. Our studies may provide a new understanding that can help drug screening and drug discovery to prevent adverse cardiac remodeling and heart failure.

PI_NAMEs: SHENOY, SUDHA K (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Address;Affect;Affinity;Agonist;American;aorta constriction;Apoptosis;Autophagocytosis;Autophagosome;beta-2 Adrenergic Receptors;Biomechanics;Blood Pressure;C57BL/6 Mouse;Cardiac;Cardiac Myocytes;Cardiomegaly;cardioprotection;Cellular Stress;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Compensation;Complex;Control Groups;Coupling;Cyclic AMP-Dependent Protein Kinases;desensitization;Deubiquitination;Development;Down-Regulation;drug discovery;Drug Screening;experimental study;Fibrosis;Functional disorder;G-Protein-Coupled Receptors;Genes;GTP-Binding Proteins;Heart;Heart failure;heart function;Heart Hypertrophy;Human;Hypertension;hypertensive;Hypertrophy;in vivo;Isoproterenol;Knock-in Mouse;Knockout Mice;Label;Left Ventricular Hypertrophy;Left Ventricular Remodeling;Ligands;Link;LoxP-flanked allele;Lysine;Mass Spectrum Analysis;Mediating;mortality;Mus;Myocardial;Myocardial dysfunction;Myocardium;novel;Pathologic;Pathway interactions;Patients;Phosphorylation;Phosphorylation Inhibition;Play;Polyubiquitination;pressure;prevent;protein expression;Proteins;receptor;Receptor Activation;Regulation;Research;response;Role;Signal Induction;Signal Transduction;Testing;trafficking;Transducers;ubiquitin isopeptidase;ubiquitin-specific protease;Ubiquitination

PROJECT_TITLE: Regulation of myocardial GPCRs by USP20 in normal and hypertrophied heart

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


PI_NAMEs: LITHGOW, GORDON J (contact)

PROJECT_TERMS: Administrator;Aging;Award;Biology of Aging;Breathing;California;career;Collaborations;Communication;Communication Methods;Communities;Country;Decision Making;design;Development;Faculty;Financial Support;Geroscientist;Goals;Human Resources;Infrastructure;innovation;Lead;Measures;Mentors;Modeling;next generation;operation;Outcome;outreach;Pilot Projects;Policies;Postdoctoral Fellow;Principal Investigator;programs;Published Comment;Reporting;Research;Research Activity;research and development;Research Institute;Research Personnel;Research Project Grants;Resource Development;Resources;Services;Shock;Site Visit;Source;Specialist;Structure;Technology;Training;Training Activity;United States National Institutes of Health;Universities;verdin photosensitizer;webinar;Writing

PROJECT_TITLE: USC-Buck Institute Nathan Shock Admin Core


NIH_SPENDING_CATS: Aging;Genetics

PI_NAMEs: SCHILLING, BIRGIT  (contact)

PROJECT_TERMS: Adopted;age related;age-related disease;Aging;Apoptosis;Apoptotic;Biological;Biological Assay;California;Cell Aging;Cell Death;Cells;chemokine;Consultations;Core Facility;Cultured Cells;cytokine;Data;Disease;DNA;DNA Methylation;Drosophila melanogaster;Enzyme-Linked Immunosorbent Assay;Event;exosome;experience;experimental study;feature selection;Goals;Growth Factor;hallmarks of aging;immunocytochemistry;Inflammatory;interest;Intervention;Lipids;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;Methods;MicroRNAs;model organism;Modeling;Molecular;Molecular Weight;Nature;Necrosis;Nerve Degeneration;Nucleic Acids;Organ;Organism;Organoids;Pathology;Peptide Hydrolases;Phenotype;Physiological;Proliferating;Proteins;Research;Research Personnel;response;RNA;Role;Sampling;senescence associated secretory phenotype;Shapes;Shock;Standardization;Stress;Structure;Techniques;Testing;Tissues;transcriptome sequencing;Universities

PROJECT_TITLE: Cellular Senescence and Beyond Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Genetics;Human Genome

PI_NAMEs: CRIMMINS, EILEEN M (contact)

PROJECT_TERMS: Acceleration;Activities of Daily Living;Adult;Age;age related;age-related disease;aged;Aging;aging biomarker;aging process;aging related;aging related disease;Back;base;Behavioral;behavioral phenotyping;biodemography;Bioinformatics;Biological;biological age;Biological Markers;Biological Models;Biological Process;Blood;blood-based biomarker;California;Cardiovascular Diseases;cardiovascular risk factor;Cognition;Cognitive;cognitive function;cohort;Communities;Data;data repository;density;design;Development;Disease;Disease Marker;DNA Methylation;Emotional;Environment;Epigenetic age;Epigenetic Process;epigenomics;ethnic diversity;Ethnic Origin;Experimental Designs;experimental study;follow-up;frailty;Gender;Gene Expression;Genes;Genetic;Genetic Transcription;genomic data;Genomics;Genotype;Geroscience;Geroscientist;Goals;hallmarks of aging;Health and Retirement Study;healthspan;Heterogeneity;high dimensionality;Homeostasis;Human;human data;Immune;Impaired cognition;indexing;Individual;Inflammaging;innovation;insight;interdisciplinary collaboration;interest;Intervention;Investments;life span;Linkage Disequilibrium;Longevity;Longitudinal Studies;Measures;Metabolism;Methods;Methylation;Mission;model organism;mortality;normal aging;novel;Outcome;Participant;pathological aging;phenome;Phenotype;Physiological;Population;Process;Race;racial diversity;Research;Research Personnel;Research Project Grants;resilience;Resources;Role;Route;Sampling;Scanning;Services;sex;Shock;social;Subgroup;System;telomere;Therapeutic;Time;tool;transcriptomics;Translation Process;translational genomics;Translational Research;Translations;Universities;Validation;Variant;Vitamin Deficiency;Work

PROJECT_TITLE: Genomic Translation Across Species Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Digestive Diseases;Genetics;Neurosciences;Nutrition;Obesity

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative The objective of our studies is to investigate the neural mechanisms underlying satiation. Our studies will utilize state-of-the-art research techniques that have the potential to identify novel and effective therapeutic strategies for treating obesity. 1

PI_NAMEs: CAMPOS, CARLOS A (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Ablation;Affective;Afferent Neurons;Afferent Pathways;Area;Behavior;Behavior Control;Body Weight;Brain;brain pathway;Calcitonin Gene-Related Peptide;Cardiovascular Diseases;Cells;Chemicals;Chronic;Clinical;comorbidity;Complex;Consumption;Cre driver;Data;Desire for food;Devices;diet-induced obesity;Dissection;Dorsal;Eating;effective therapy;Endocrine;energy balance;Excision;Feeding behaviors;Feeling;food quality;Future;Gastrointestinal tract structure;genetic manipulation;Goals;Health;hindbrain;Homeostasis;Hunger;Implant;insight;Learning;Link;manufacture;Molecular Genetics;Mus;Nausea;neural;neural circuit;neural network;neuromechanism;Neurons;Neuropeptides;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;obese patients;Obesity;obesity treatment;Operative Surgical Procedures;Opsin;optogenetics;Organ Specificity;Pathway interactions;Peripheral;Physiological;Physiology;Population;rabies viral tracing;Reflex action;Regulation;Reporter;Research;Research Personnel;Research Technics;response;Role;Satiation;satisfaction;Sensory;Signal Transduction;single-cell RNA sequencing;Somatostatin;Specific qualifier value;stem;Stimulus;Stomach;System;Techniques;Technology;Testing;therapeutically effective;tool;Training;Transcript;Transgenic Organisms;transmission process;urocortin;Vagus nerve structure;Viral;Virus;Visceral;wireless;Wireless Technology

PROJECT_TITLE: Dissecting Viscerosensory Pathways Controlling Feeding Behavior

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Aging;Bioengineering

PI_NAMEs: MELOV, SIMON  (contact)

PROJECT_TERMS: Acceleration;Address;age-related disease;Aging;aging biomarker;aging mechanism;Applications Grants;Artificial Intelligence;Award;Biological;Biological Markers;Biological Models;Biology of Aging;biomarker development;California;Cell Respiration;Cellular biology;Clinical;Collaborations;Collection;Communities;Core Facility;design;Ensure;Equipment;Experimental Designs;Faculty;Flow Cytometry;fly;Genomics;Geroscience;Geroscientist;Grant;healthspan;Image;innovative technologies;Institution;instrumentation;Killifishes;Knowledge;Mass Spectrum Analysis;Measures;Mentors;Mentorship;Metabolic;Metabolic Pathway;Metabolism;Methodology;Mitochondria;model organism;Modernization;Morphology;Mus;new technology;next generation;Participant;Phenotype;Reactive Oxygen Species;Research;Research Activity;Research Design;Research Personnel;research study;resilience;Resources;sabbatical;Sampling;Science;Services;Shock;single cell genomics;success;synergism;Technology;technology development;technology platform;tool;Training;Universities;voucher;Yeasts

PROJECT_TITLE: Geroscience Technology Core


NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Machine Learning and Artificial Intelligence;Nutrition;Obesity;Patient Safety;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative Although over 40,000 obese individuals with end-stage kidney disease initiate dialysis each year in the United States, there are no guidelines on optimal obesity management in the setting of dialysis care. Obese dialysis patients may lose weight due to chronic illness or due to intentional weight loss attempts, though it is difficult to differentiate between healthy and unhealthy weight loss in these patients. This proposal seeks to advance the science of obesity management in dialysis settings by providing new tools to differentiate between healthy and unhealthy weight loss trajectories among obese dialysis patients.

PI_NAMEs: HARHAY, MEERA NAIR (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: adverse outcome;Benefits and Risks;Biological Markers;Blood Pressure;Body Composition;Body mass index;Body Weight;Body Weight decreased;Caring;Cessation of life;Characteristics;Chronic;Chronic Disease;Classification;Clinical;clinical care;clinical predictors;cohort;Confidence Intervals;Consensus;Data;data registry;Data Set;Dialysis patients;Dialysis procedure;Dietitian;Dimensions;End stage renal failure;Enrollment;Ensure;experience;Foundations;Goals;Guidelines;hazard;Health;health related quality of life;Health Status;healthy weight;Hemodialysis;hemodynamics;high risk;Hospitalization;improved;improved mobility;Individual;Inflammation;Inflammatory;inflammatory marker;Intake;Interview;Joints;Kidney;Kidney Diseases;Kidney Transplantation;Kilogram;Knowledge;Link;longitudinal, prospective study;Machine Learning;machine learning algorithm;machine learning prediction;Malnutrition;Measures;Medical;meter;Modeling;morphogens;mortality;mortality risk;muscle form;Muscle function;muscle strength;Muscular Atrophy;Nephrology;Non obese;novel;nutrition;Nutritional;obese patients;obese person;Obesity;obesity management;Outcome;patient population;Patient-Centered Care;Patient-Focused Outcomes;Patients;Persons;Phenotype;Physicians;Physiological;Population;predictive tools;prevent;Process;prospective;Prospective, cohort study;Provider;Quality of life;reduced muscle strength;Reporting;Research;Research Proposals;Risk;Risk Factors;sarcopenia;Science;Services;sleep quality;stakeholder perspectives;Structure;Techniques;tool;Transplant Recipients;United States;Vulnerable Populations;Weight;weight loss intervention

PROJECT_TITLE: Identifying Healthy and High-Risk Weight Loss Phenotypes to Optimize Obesity Management in End Stage Kidney Disease

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Chronic Pain;Dental, Oral, and Craniofacial Disease;Neurosciences;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative TMJ inflammation causes excruciating pain that prevents people from talking, eating, or drinking, but there is no effective treatment. We will demonstrate how TRPV1 modulates oral inflammatory pain through ChemR23, which will help develop effective therapies and understand how neurogenic inflammation is controlled.

PI_NAMEs: BANG, SANGSU  (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Absence of pain sensation;Acute;Acute inflammatory pain;Address;Affect;Afferent Neurons;Agonist;American;Analgesics;Anatomy;Animal Model;Animals;Anti-Inflammatory Agents;ATAC-seq;Behavioral;behavioral phenotyping;Binding;Biological Assay;Bite Force;Capsaicin;cell type;Cells;Chronic;Chronic inflammatory pain;chronic pain;chronic pain management;Clinical;clinical translation;CMKLR1 gene;conditioned place preference;craniofacial;Data;Databases;Detection;Development;Disease;drinking;Eating;effective therapy;Enzyme-Linked Immunosorbent Assay;Exhibits;experimental study;Face;Female;Flow Cytometry;Functional disorder;Future;G-Protein-Coupled Receptors;Gene Expression Profile;Generations;Human;human tissue;Immune;Impairment;Individual;Inflammation;Inflammation Mediators;inflammatory pain;inhibitor;Injections;Injury;innovation;insight;Ion Channel;knock-down;lipid mediator;Macrophage;male;Measurement;Measures;Mechanics;Mediating;Methods;Modeling;Molecular;Mus;Nervous System;Neurogenic Inflammation;Neurons;new therapeutic target;novel;novel therapeutics;Omega-3 Fatty Acids;Oral;orofacial;Orofacial Pain;Pain;Pain management;pain model;pain processing;Pathology;Pathway interactions;Pattern;Persistent pain;Persons;prevent;Production;Property;receptor;Receptor Signaling;Research;Resolution;Role;Saliva;Sampling;Secondary to;Series;Serum;sex;Signal Pathway;Signal Transduction;small hairpin RNA;Specificity;Spinal Ganglia;spontaneous pain;Structure of trigeminal ganglion;Temporomandibular Joint;Temporomandibular Joint Disorders;Testing;Time;tissue injury;Tissues;TNF gene;translational impact;Trigeminal Pain;Trigeminal System;TRP channel;TRPV1 gene;United States National Institutes of Health;Vibrissae;Virus;Western Blotting

PROJECT_TITLE: Resolvin receptor signaling in trigeminal sensory neurons

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: SURGERY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: NARRATIVE Recent advances in cancer immunotherapy have irrefutably demonstrated the powerful ability of the immune system to destroy cancer through the activity of T cells, however the benefits of these treatments have been restricted to a small percentage of patients. We found that cancer cell death leads to an altered abundance of potassium within tumors, which acts as a previously unidentified ionic check upon T cell antitumor function. The proposed research will assess the functional consequences for cell death and local potassium release for in vivo T cell antitumor function in human cancers, leverage our preliminary data to define a non-canonical role for intracellular potassium (K+), and test novel cancer treatments based on the directed manipulation of T cell potassium transport.

PI_NAMEs: EIL, ROBERT LANGLAND (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Adoptive Transfer;Affect;anti-CTLA4;Autologous;Binding;Biological;Biological Process;cancer cell;cancer immunotherapeutics;cancer immunotherapy;cancer therapy;cancer type;Cell Death;Cell Death Induction;Cell Physiology;Cells;Cellular biology;Cellular immunotherapy;chimeric antigen receptor T cells;combinatorial;CTLA4 gene;cytokine;cytotoxic;Cytotoxic Chemotherapy;Data;Disease Progression;effector T cell;experimental study;extracellular;FRAP1 gene;Functional disorder;Genetic;Genomics;Holoenzymes;Homeostasis;Human;Immune;immune activation;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune Evasion;immune resistance;Immune signaling;Immune system;Immune System Diseases;Immunobiology;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Inflammasome;Injury;insight;Intervention;Intrahepatic Cholangiocarcinoma;Ion Transport;Knowledge;Ligation;Malignant Neoplasms;Mediating;Modeling;Modification;Molecular;mouse model;Myelogenous;Myeloid Cells;Nature;Necrosis;novel;Oncology;Operative Surgical Procedures;Pathway interactions;Patients;Pattern;pharmacologic;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Post-Translational Protein Processing;Potassium;prevent;Primary Malignant Neoplasm of Liver;Production;Prognosis;programmed cell death protein 1;programs;Protein Phosphatase 2A Regulatory Subunit PR53;Proto-Oncogene Proteins c-akt;Receptor Signaling;Recurrence;Regimen;Reporting;Research;Research Personnel;Resected;Resistance;Role;Sampling;Science;Signal Transduction;Site;Specimen;Sum;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;theories;Time;Tissues;Translating;tumor;tumor heterogeneity;Tumor Immunity;tumor microenvironment;tumor progression;Widespread Disease;Work

PROJECT_TITLE: Targeting an unrecognized checkpoint on T cell function in tumors

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Heart Disease;Hypertension;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE There is strong commitment in sub-Saharan Africa, and globally, to improve hypertension treatment as a key part of the global strategy to reduce cardiovascular disease mortality by 25% by the year 2025. As hypertension diagnosis and medication availability improve, there is a critical need for interventions to improve patient- centeredness and patient engagement in chronic hypertension care in order to achieve and maintain the long- term benefits of hypertension treatment. In this K23 proposal, I will develop and pilot test a theory-informed implementation strategy to improve hypertension treatment adherence among people with and without HIV in the context of an integrated chronic HIV-hypertension care model in rural western Kenya.

PI_NAMEs: HICKEY, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: ILIAS, MALIHA R

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Africa;Africa South of the Sahara;AIDS prevention;behavior change wheel;Blood Pressure;blood pressure control;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;care delivery;care systems;Caring;Center for Translational Science Activities;Chronic;Chronic Care;chronic care model;Clinic;Clinic Visits;Clinical;Clinical Research;cost effective;Data;design;Diagnosis;Disease;Effectiveness;Ensure;Evaluation;Evidence based intervention;experience;experimental study;Funding;Goals;Guidelines;Health;Health Personnel;Health system;HIV;Hypertension;hypertension control;hypertension prevention;hypertension treatment;hypertensive;implementation barriers;implementation outcomes;implementation research;implementation science;implementation strategy;improved;integrated care;Intervention;Interview;Kenya;Learning;Long-Term Care;Maps;medication compliance;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Outcome;patient engagement;patient oriented;Patient Preferences;Patient-Focused Outcomes;patient-level barriers;Patients;Persons;Pharmaceutical Preparations;Pilot Projects;pilot test;Population;pragmatic trial;preference;Premature Mortality;Process;Proctor framework;Provider;Public Health;Research;Research Methodology;Research Personnel;Risk Factors;Rural;Sampling;secondary outcome;Site;skills;Structure;Surveys;Testing;Theoretical Domains framework;theories;therapy development;Training;treatment adherence;Treatment outcome;Uganda;United States National Institutes of Health;Well in self

PROJECT_TITLE: Implementation Strategies to Improve Hypertension Treatment in Kenya

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Little progress has been made in the treatment of patients with EWS fusion driven cancer, including Ewing sarcoma, a pediatric solid tumor driven by the EWS/FLI1 fusion oncoprotein. In this proposal, we will evaluate the novel hypothesis that Ewing sarcoma tumors are susceptible to oncogene overdose through decreasing TRIM8, the E3 ligase for EWS/FLI1. We will determine the mechanisms governing the EWS/FLI1 and TRIM8 interactions, including condensate formation; the impact of TRIM8 repression on epigenetic states; and test the hypothesis that the glutamate receptor GRM2 mediates toxicity downstream of EWS/FLI1 overdose mediated by TRIM8 repression.

PI_NAMEs: RIVERA, MIGUEL NICOLAS;STEGMAIER, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: 3-Dimensional;Acute;Binding;Biology;bone;Cell Death;Cells;Child;Childhood;Childhood Solid Neoplasm;Chimeric Proteins;ChIP-seq;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;Cytotoxic Chemotherapy;Data;Data Set;Dependence;Disease;disorder control;Doxycycline;Epigenetic Process;epigenome editing;Ewings sarcoma;experimental study;FLI1 gene;FLI1 Transcription Factor;Fusion Oncogene Proteins;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;genome-wide;Glutamate Receptor;Goals;Growth;high risk;Human;innovation;Knowledge;Laboratories;Lead;Malignant Bone Neoplasm;Malignant Childhood Neoplasm;Malignant Neoplasms;Measurement;Measures;Mediating;metabotropic glutamate receptor 2;Molecular Conformation;mutant;Mutation;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncogenic;Open Reading Frames;Operative Surgical Procedures;optogenetics;Other Genetics;Overdose;overexpression;Pathogenesis;Pathway interactions;Patients;Pediatric Oncology;Phase Transition;Physical condensation;Predisposition;Prion Diseases;prion-like;Property;protein degradation;Radiation therapy;rapid growth;Regulation;Regulatory Element;Relapse;Repression;RNA-Binding Protein EWS;Role;Sarcoma;screening;small hairpin RNA;Surveys;System;Testing;Therapeutic;therapeutic target;tool;Toxic effect;transcription factor;translational impact;Treatment Protocols;tumor;ubiquitin ligase;ubiquitin-protein ligase

PROJECT_TITLE: Mechanisms of Toxicity Induced by EWS/FLI1 Overdose in Ewing Sarcoma

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Rare Diseases

ORG_CITY: RICHLAND

ORG_NAME: BATTELLE PACIFIC NORTHWEST LABORATORIES

PHR: PROJECT NARRATIVE Cancer is a disease that often originates in genomic abnormalities; however, these genome-level defects exert its functional significance at the level of proteins. Coordinating within the Clinical Proteomic Tumor Analysis Consortium, the Proteome Characterization Center at the Pacific Northwest National Laboratory will comprehensively characterize the protein- (including multiple protein modifications such as phosphorylation) and metabolomic-level changes in cancer and healthy states by combing proteome-, metabolome-, and genome-level information. This will contribute to a more unified understanding of cancer biology with translational potential, e.g., development of new cancer diagnostic, prevention, and treatment strategies.

PI_NAMEs: LIU, TAO  (contact)

PROGRAM_OFFICER_NAME: HILTKE, TARA

PROJECT_TERMS: Achievement;advanced analytics;Affinity;Area;Automobile Driving;Basic Science;Biochemical Process;Bioinformatics;Biological Assay;Biological Models;Cancer Biology;Cancer Diagnostics;cancer genome;cancer type;Catalogs;Cell Line;Cells;Center for Translational Science Activities;Chromatography;Classification;Clinical;clinical center;cohort;Colon Carcinoma;Communities;Complement;Data;data acquisition;Data Analyses;data integration;data quality;Defect;Development;diagnostic strategy;Disease;Drug Targeting;Endometrial Carcinoma;expectation;experience;functional status;Genome;genomic data;genomic profiles;Genomics;Genotype;Glioblastoma;Guidelines;Human;human genome sequencing;improved;Informatics;informatics tool;Infrastructure;insight;instrumentation;International;Label;Laboratories;Link;lipidome;Liquid Chromatography;Malignant neoplasm of ovary;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;meetings;Metabolic;Metabolic Pathway;metabolome;metabolomics;Metals;Methods;Mission;Molecular;Monitor;multidisciplinary;multiple omics;Mutation;nanoscale;National Cancer Institute;new technology;Organoids;Outcome;Pacific Northwest;Pathway Analysis;patient derived xenograft model;Performance;personalized medicine;phenome;Phenotype;Phosphorylation;Post-Translational Protein Processing;pre-clinical;precision oncology;Prevention strategy;Prognostic Marker;prospective;protein degradation;protein protein interaction;Proteins;proteogenomics;Proteome;Proteomics;Publishing;Reaction;Role;Route;Sample Size;Sampling;Series;Serous;Signal Pathway;Signal Transduction;Specimen;stable isotope;success;tandem mass spectrometry;Technology;technology development;The Cancer Genome Atlas;Therapeutic Intervention;therapeutic target;transcriptomic profiling;translational applications;translational potential;treatment strategy;tumor;tumor behavior;tumor heterogeneity;Validation;Work;working group

PROJECT_TITLE: Center for Advanced Multi-Omic Characterization of Cancer


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW YORK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Genomic and epigenomic abnormalities collaborate in disease initiation and progression, as exempliﬁed by frequent mutations in protein-coding genes which can vary spatially in separated sub-regions of tissues. This project will develop computational methods to infer tissue-spatial epigenomic landscape which can not be measured using current techniques, leveraging the emerging technologies of spatial transcriptomics, and develop novel statistical methods to identify differential epigenomic signals across patients or cell populations. The outcome of this project can lead to the development of new epigenetic targeted therapy and new epigenetic therapeutic drugs for various diseases that helps the broad community.

PI_NAMEs: HOU, WENPIN  (contact)

PROGRAM_OFFICER_NAME: GAO, JEAN XUEJING

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Aging;Atlases;Award;Biometry;Calibration;career;career development;cell type;Cells;Chromatin;clinical practice;clinical translation;Clinical Trials;Code;Collaborations;Communities;Computing Methodologies;computing resources;CpG dinucleotide;Data;Data Set;deep learning;deep learning model;Development;developmental disease;Developmental Process;Disease;disease classification;disorder prevention;DNA;DNA analysis;DNA Methylation;DNA Methyltransferase Inhibitor;DNA Sequence;Doctor of Philosophy;Early Diagnosis;Emerging Technologies;Encyclopedia of DNA Elements;Engineering;Epigenetic Process;epigenome;epigenomics;Evaluation;experimental study;Funding;Gene Expression;Gene Expression Regulation;gene regulatory network;gene repression;Genes;Genetic Transcription;genomic data;Genomic Segment;Genomics;Goals;Hong Kong;Human;Immune checkpoint inhibitor;Immune response;improved;insight;interest;Joints;Link;Location;Malignant Neoplasms;Mammals;Mathematics;Measurement;Measures;Medicine;Mentors;Methodology;Methods;Methylation;Modeling;multimodal data;Multiomic Data;Mutation;novel;Outcome;Patients;Pharmaceutical Preparations;Phase;Phenotype;Population;Population Heterogeneity;Postdoctoral Fellow;Prediction of Response to Therapy;Productivity;Prognosis;programs;Promoter Regions;Proteins;Protocols documentation;Public Health Schools;reference genome;Regulation;Research;Research Personnel;Resolution;Resources;Sample Size;Sampling;Series;Signal Transduction;single cell genomics;single-cell RNA sequencing;Site;Statistical Methods;statistics;System;targeted treatment;Techniques;Technology;Therapeutic;therapeutic target;Tissues;tool;Training;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Universities;Variant;Work

PROJECT_TITLE: Computational Methods for Inferring Single-cell DNA Methylation and its Spatial Landscape


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;HIV/AIDS;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Prevention;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative: With the ongoing scale up of Dolutegravir (DTG), an integrase strand transfer inhibitor antiretroviral treatment, in Sub-Saharan Africa, weight gain has been noted in postpartum women living with HIV. How maternal DTG impacts the physiology of maternal and infant body weight regulation has not been studied. In a cohort of maternal-infant dyads from Uganda, we propose to study how DTG-based regimens affects energy intake and expenditure along with biological measures of appetite and metabolic pathways relevant in weight regulation.

PI_NAMEs: AIZIRE, JIM K;SHIVAKOTI, RUPAK  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Address;Adult;adverse birth outcomes;Affect;Africa;Africa South of the Sahara;antiretroviral therapy;Appetite Regulation;Appetite Stimulants;Biological;Body Composition;Body Weight;Body Weight decreased;Breastfed infant;clinical research site;clinically significant;cohort;comorbidity;Conduct Clinical Trials;Control Groups;cost;Data;Desire for food;dietary;Dietary Fiber;Disease;disorder risk;doubly-labeled water;Dual-Energy X-Ray Absorptiometry;efavirenz;Energy Intake;Energy Metabolism;Enrollment;Expenditure;Fatty acid glycerol esters;Formulation;Future;Growth;Health;high risk;HIV;HIV-exposed uninfected infant;Hormones;improved;increased appetite;Infant;inhibitor;insight;Intake;Integrase;Intervention;Investigation;Knowledge;Lactation;Length;Limb structure;Link;Maternal Physiology;maternal risk;Measures;Metabolic;Metabolic Pathway;metabolic profile;metabolome;microbiome;Mothers;non-nucleoside reverse transcriptase inhibitors;Obesity;Outcome;Overweight;Peptides;Persons;Phenotype;Physiological;Physiology;pill;Population;Postpartum Period;postpartum weight;Postpartum Women;Pregnancy;Probiotics;prospective;Prospective, cohort study;Questionnaires;Randomized;Regimen;Regulation;Research;Resistance;Risk;Risk Reduction;scale up;Special Population;standard of care;Therapeutic;Thinness;Treatment Protocols;Uganda;Universities;Volatile Fatty Acids;Weight;Weight Gain;Woman

PROJECT_TITLE: Metabolic impact of ART on women living with HIV and their infants


ADMINISTERING_IC: NS

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: NARRATIVE G-protein–coupled receptors (GPCRs), the largest class of membrane signaling proteins, represent one of the broadest class of drug targets. The GPCRs that respond to glutamate, the main excitatory neurotransmitter of the brain, the mGluRs, have been implicated in various neurological disorders and identified as potential drug targets. We propose to study the molecular mechanisms that set and regulate their function at synapses and that can be used in drug assays in the nervous system.

PI_NAMEs: ISACOFF, EHUD  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Affinity;Allosteric Regulation;Arrestins;Biological Assay;Brain;Cells;Coupled;design;Diffusion;dimer;Dimerization;drug development;Drug Targeting;Enzymes;extracellular;fascinate;Fluorescence Resonance Energy Transfer;G-Protein-Coupled Receptors;Glutamates;Goals;GTP-Binding Proteins;Heterodimerization;Homo;Hybrids;Intercellular Junctions;Label;Ligands;member;Membrane;Metabotropic Glutamate Receptors;Methods;Modeling;Molecular;Molecular Conformation;Monitor;Nervous System;Nervous System Disorder;Neuroglia;Neurotransmitter Receptor;neurotransmitter release;Neurotransmitters;Optical Methods;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;positive allosteric modulator;postsynaptic;presynaptic;presynaptic neurons;Property;Proteins;Pump;receptor;Receptor Activation;receptor function;Receptor Signaling;Regulation;response;Rotation;Signal Transduction;Signaling Protein;Site;spatiotemporal;Stimulus;Structure;Subgroup;Synapses;Synaptic Cleft;synaptic inhibition;Synaptic Transmission;Tertiary Protein Structure;Testing;transmission process;Work

PROJECT_TITLE: Conformational mechanisms of mGluR gating and regulation

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Heart Disease;Patient Safety;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative People with heart failure who do not take their medications as prescribed are at high risk of complications leading to hospitalization, death and poor quality of life. In the proposed intervention, nurses will use easy-to- understand language to coach patients and their care partners to help them work together and build skills to overcome their individual barriers to adherence in order to improve and sustain patient medication adherence. If effective, this intervention will support long-term medication adherence, thus reducing hospitalizations and deaths related to heart failure.

PI_NAMEs: WU, JIA-RONG  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Address;Adherence;Adverse effects;Affect;Agreement;Appointment;attentional control;Attitude;Back;Behavior;Behavior Control;Behavioral;Caring;Cause of Death;Cessation of life;Chronic;Clinic;Communication;comparison control;comparison intervention;Complex;Control Groups;Educational Materials;Educational process of instructing;effectiveness/implementation trial;efficacy evaluation;efficacy testing;empowerment;Event;evidence base;Family;Family member;family support;follow-up;fourth grade;Friends;Goals;group intervention;Health;health literacy;Health Promotion;Heart failure;high risk;hospital readmission;Hospitalization;improved;Individual;innovation;Instruction;interest;Intervention;intervention effect;Language;Learning;Link;literacy;low health literacy;Mediating;Medical;medication compliance;member;Modeling;Morbidity - disease rate;mortality;Motivation;multi-component intervention;Nurses;older patient;optimism;Outcome;Partner Communications;Patient Care;Patient Compliance;Patients;Persons;Pharmaceutical Preparations;pilot test;Planning Theory;Play;post intervention;Prevention;Primary Care;primary outcome;Printing;Provider;Quality of life;Randomized;Randomized, Controlled Trials;Reading;Regimen;Research;Research Personnel;Role;Role playing therapy;secondary outcome;Self Care;skills;Social support;Spouses;Symptoms;Telephone;Testing;Time;Treatment Efficacy;United States;Work;Writing

PROJECT_TITLE: Improving medication adherence using family-focused and literacy-sensitive strategies in patients with heart failure

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE Emerging and re-emerging infectious diseases are occurring with increasing frequency and are a threat to human health in the United States and worldwide. To improve knowledge of these diseases and develop the infrastructure to conduct infectious disease research, National Institute of Allergy and Infectious Diseases (NIAID) has formed the Emerging Infectious Diseases Research Centers Network (EIDRC-Net). RTI International and Duke University propose to jointly establish the EIDRC-Net Coordination Center to provide overall Network coordination and communication and to build a research infrastructure to help NIAID respond rapidly to infectious disease outbreaks when they occur.

PI_NAMEs: MOODY, MICHAEL ANTHONY;SEMPOWSKI, GREGORY D (contact)

PROGRAM_OFFICER_NAME: SMITH, RACHELLE MARIE SIMPSON

PROJECT_TERMS: Address;Affect;Area;Award;Benchmarking;biocontainment facility;Biological Assay;Biology;career;Central Africa;Central America;Childhood;cloud based;Collaborations;Communicable Diseases;Communication;Consensus;Coordination and Collaboration;Country;Data;data acquisition;data quality;Disease;Disease Outbreaks;disease transmission;Doctor of Philosophy;electronic data capture system;Emerging Communicable Diseases;Ensure;Epidemic;Event;experience;flexibility;Frequencies;Funding;Geographic Locations;Goals;Health;high risk;Home;Human;improved;Infectious Diseases Research;Information Management;Infrastructure;International;Joints;Knowledge;Laboratories;Leadership;Location;Medical;Medical Research;Mentors;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;next generation;Performance;Persons;Principal Investigator;Privatization;Procedures;Process;programs;Protocols documentation;quality assurance;Reagent;repository;Research;Research Design;Research Infrastructure;Research Personnel;Resource Sharing;Resources;response;Scientist;Security;Site;social media;Southeastern Asia;Specialist;Specimen;success;System;Testing;Training;United States;United States National Institutes of Health;Universities;usability;Vaccines;web site;ZIKA

PROJECT_TITLE: Emerging Infectious Diseases Research Centers Coordination Center (EIDRC CC)


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Precision Medicine

ORG_CITY: Nashville

ORG_DEPT: CHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Identifying the genetic variants responsible for patient phenotypes is challenging, especially for rare diseases. We will develop algorithms for interpreting variants of unknown clinical significance by modeling the effects of all variants in a patient on protein 3D structures, integrating structural features with machine learning, and using systems biology to identify functional interactions between variants. In collaboration with the Undiagnosed Dis- eases Network, we will develop and validate mechanistic hypotheses about the genetic basis for disease and establish a foundation for personalized treatments that reflect patients’ unique genetic backgrounds.

PI_NAMEs: CAPRA, JOHN ANTHONY;MEILER, JENS  (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: 3-Dimensional;Address;algorithm development;Algorithms;base;Benign;Biology;Clinic;Clinical;clinical sequencing;clinically relevant;clinically significant;Code;Collaborations;computer framework;computerized tools;Computing Methodologies;Data;Databases;Development;Diagnosis;Disease;disease-causing mutation;Enrollment;exome;follow-up;Foundations;Generations;Genetic;Genetic Annotation;Genetic Code;Genetic Diseases;genetic information;genetic variant;Genetic Variation;Genome;Genomics;Goals;Human;Human Genetics;Individual;individual patient;innovation;insertion/deletion mutation;Joints;Large-Scale Sequencing;Machine Learning;machine learning method;Maps;Methods;Modeling;Molecular;Mutation;Network-based;participant enrollment;Pathogenicity;patient responsibilities;Patients;personalized medicine;personalized predictions;Phenotype;Positioning Attribute;precision medicine;protein function;protein structure;Proteins;Proteome;Rare Diseases;Set protein;Site;structural biology;Structural Models;Structure;success;System;Systems Biology;targeted treatment;Therapeutic;three dimensional structure;tool;Training;Treatment Step;treatment strategy;Validation;Variant;variant of unknown significance;Visualization

PROJECT_TITLE: Personalized Structural Biology: Enabling Exome Interpretation in Undiagnosed Diseases

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric

ORG_CITY: RICHARDSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: PROJECT NARRATIVE The proposed research study investigates the neurobiological profile of young adults with persistent Developmental Language Disorder. DLD can lead to significant limitations in communication, and interpersonal, academic, and occupational success. The link between the behavioral phenotype of the disorder and brain structure and function will be examined in a group of adults with and without DLD (18;0 - 21:0) to facilitate successful targeted treatments of neurodevelopmental language disorders in young adults.

PI_NAMEs: EVANS, JULIA L (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Adolescent;Adolescent and Young Adult;Adult;Age;Anatomy;Anxiety;Area;Auditory;autism spectrum disorder;automated analysis;Award;behavioral phenotyping;Biological Markers;Brain;Brain imaging;Child;Child Language;Classification;Clinical;Cognition;Cognitive;cognitive neuroscience;Collaborations;Communication;Complex;Computer Models;cost effective;Coupled;Data;density;design;Development;developmental disease;Diagnostic;diffuse optical tomography;Dimensions;Disease;Dyslexia;Elasticity;Electroencephalography;Emerging Technologies;emotion regulation;Emotional;Environment;Exclusion Criteria;executive function;experience;Extramural Activities;Failure;Family;Foundations;Friends;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Funding;Genetic;Goals;Grant;Head;Hearing;hemodynamics;Heterogeneity;High Prevalence;High-dimensional Modeling;Human;Image;Impairment;Imprisonment;indexing;Individual;Individual Differences;interest;Knowledge acquisition;Language;language comprehension;Language Development Disorders;Language Disorders;language impairment;language processing;Language Tests;Learning Skill;life span;Link;Logistic Regressions;Machine Learning;machine learning method;Magnetic Resonance Imaging;Maps;Measures;Medical;meetings;member;Mental Depression;Mentors;Mentorship;Metals;Methods;Modeling;Morphologic artifacts;Motion;MRI Scans;multimodality;neural;Neuroanatomy;Neurobiology;Neurodevelopmental Disorder;neuroimaging;Neurologic;Neurosciences;Noise;novel;novel strategies;Occupational;optical imager;optical imaging;Optical Tomography;Optics;Participant;Pattern;peer;Population;portability;Production;programs;Qualifying;Recording of previous events;Research;Research Personnel;Research Project Grants;research study;Resolution;response;Risk;Sample Size;Sampling;School-Age Population;Scientist;Sensory;Series;Services;Severities;Short-Term Memory;Signal Transduction;skills;Social isolation;Societies;source localization;specific language impairment;Speech;Standardization;Structure;success;Target Populations;Techniques;temporal measurement;Three-Dimensional Image;Training;trait;Travel;United States;United States National Institutes of Health;verbal;Williams Syndrome;Work;young adult

PROJECT_TITLE: Characterization of the Neurobiological Profiles of Young Adults with and without Developmental Language Disorder (DLD)

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]