NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE: Despite significant progress in the fight against pancreatic cancer, survival rates are dismal and the prognosis remains bleak, with only about 10% of patients living longer than 5 years following diagnosis. There is a dire need for new treatment strategies and pre-clinical models to evaluate emerging therapeutic approaches. This interdisciplinary proposal will evaluate High Frequency Irreversible Electroporation (H-FIRE), which is a non-thermal tumor ablation modality that induces transient nanoscale defects in the plasma membrane that ultimately results in cancer cell death and the activation of a systemic anti-tumor immune response that limits metastasis, in pre-clinical mouse and novel orthotopic pig models in support of future human clinical trials.

PI_NAMEs: ALLEN, IRVING C (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Ablation;Address;Aftercare;Anatomy;Animal Model;anti-tumor immune response;Apoptosis;biophysical properties;Biophysics;Blood Vessels;cancer cell;Cancer cell line;Cell Death;Cell membrane;Cessation of life;Chemotherapy and/or radiation;Clinical;Clinical Research;clinical translation;Clinical Trials;clinically relevant;Complication;Data;Defect;Development;Diagnosis;Diameter;Disease;Distal;Duct (organ) structure;effective therapy;electric field;electric impedance;Electrodes;Electroporation;Elements;Family suidae;Feedback;fighting;Fourier Analysis;Frequencies;Future;Geometry;Heterogeneity;Human;Immune response;Immune system;Immunocompetent;Immunocompromised Host;Immunology;In Situ;in vivo;Injury;Interphase;invention;ionization;Location;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Methods;Modality;mouse model;Mus;nanoscale;Necrosis;Neoplasm Metastasis;Nerve;Nodule;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Pancreas;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;Pancreatic duct;pancreatic neoplasm;Pancreatitis;patient derived xenograft model;Patients;physical property;Physiologic pulse;Physiological;Physiology;Play;porcine model;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Prognosis;Protocols documentation;Recurrence;response;Risk;Role;Safety;Series;Site;Solid Neoplasm;Spectrum Analysis;Stenosis;Structural defect;Structure;Survival Rate;Techniques;Technology;Testing;Theoretical Studies;Therapeutic;Time;Tissues;translation to humans;Treatment Protocols;treatment strategy;tumor;tumor ablation;Tumor Burden;tumor heterogeneity;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Tissue;tumor xenograft;United States;Unresectable;Width;Work

PROJECT_TITLE: Optimization of High Frequency Irreversible Electroporation (H-FIRE) for tumor ablation and immune system activation in pancreatic cancer applications

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative The proposed research is relevant to public health because social disconnection is a major risk factor for poor physical and mental health and it rises steeply during adolescence. The project is relevant to NICHD’s priorities because it seeks to understand social isolation across development, reveal family-level risk and protective factors for social disconnection, and identify targets for behavioral and biological intervention.

PI_NAMEs: HOSTINAR CAUDILL, CAMELIA E (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 16 year old;Acute;Adolescence;Adolescent;Adult;Affect;affiliative behavior;Age;Behavior;Behavioral;biobehavior;Biologic Characteristic;Biological;biological adaptation to stress;Biological Assay;Biology;California;Characteristics;Conflict (Psychology);COVID-19 pandemic;Data;Data Collection;Development;Emotional;Evaluation;Exhibits;experience;Family;fighting;Fostering;Freezing;Future;Health Benefit;Hispanic;improved;Inflammatory;Intervention;Introversion;Laboratories;Life;Loneliness;longitudinal dataset;Longitudinal Studies;Low income;Mental Health;Mexican;Modeling;National Institute of Child Health and Human Development;Neurotic Disorders;Oxytocin;Parents;Participant;Pattern;peer;Personality;Personality Character;physical conditioning;Physiological;Population;Prevalence;Process;prospective;protective factors;Protocols documentation;Psychosocial Assessment and Care;Public Health;recruit;Reporting;Research;response;Risk;Risk Factors;Role;Sampling;Schools;secondary analysis;Shyness;social;Social Behavior;Social Development;Social Distance;social engagement;social exclusion;social factors;Social isolation;social relationships;social stressor;Social support;Stress;stress reactivity;stressor;Testing;theories;Time;twelfth grade;Withdrawal;Youth

PROJECT_TITLE: Understanding the Development of Social Disconnection in Youth

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative  Cells need to respond quickly to the change of the nutrient level in the environment to adjust their survival strategy. The proposed research aims to investigate the dynamics of amino acid sensing using biophysical tools. We plan to recapitulate this biological process in vitro to gain fundamental understanding of how cells coordinate their behavior based on the nutrient availability.

PI_NAMEs: SHEN, KUANG  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Amino Acids;Behavior;Biological Process;biophysical tools;Catabolism;cell growth;Cell Proliferation;Cells;Complex;Cryo-electron tomography;detection of nutrient;Environment;Eukaryotic Cell;FRAP1 gene;Guanosine Triphosphate Phosphohydrolases;In Vitro;insight;Membrane;Molecular;Molecular Conformation;novel;Nutrient;Nutrient availability;Outcome;Process;protein complex;Reaction;reconstitution;recruit;Regulation;Research;Series;Signal Transduction;single-molecule FRET;Surface;System;therapeutic development;transmission process;Visualization

PROJECT_TITLE: Spatial and temporal regulation of nutrient sensing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Prevention

ORG_CITY: COLUMBIA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative The proposed research is relevant to public health because it centers on developing multifunctional porous soft materials for next-generation user-friendly skin-interfaced cardiac sensing patches with bimodality (concurrent monitoring of heart electrical and mechanical activities) and long-term biocompatibility for early detections and timely interventions of heart diseases. The enabling device is expected to simultaneously achieve skin-like com- pliance, high stretchability, high breathability, antimicrobial property and waterproof, as well as provide long- lasting, continuous, high-fidelity, concurrent measurements of ECG and SCG signals from human chests. The device is superior to existing ambulatory cardiac monitors and will benefit the people who suffer from heart dis- eases by providing unprecedented user-friendliness for patients to wear and collecting real-time, reliable, com- prehensive (ECG and SCG) data for physicians to make crucial care decisions.

PI_NAMEs: YAN, ZHENG  (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: Accelerometer;Accounting;Address;Anti-Bacterial Agents;anti-microbial peptide;antimicrobial;Artificial Heart;bioelectronics;biomaterial compatibility;Cardiac;Caring;Cause of Death;Cessation of life;Chest;Clinical;Complement;COVID-19;Data;data acquisition;Dermatologist;Development;Devices;Early Diagnosis;Elasticity;elastomeric;Elastomers;Elderly;Electrocardiogram;Electronics;fabrication;falls;Food Preservatives;Foundations;Generations;Health Care Costs;Heart;Heart Diseases;heart electrical activity;heart visualization;Holter Electrocardiography;Home;Human;human subject;Hybrids;improved;infection risk;Inflammation;Inflammatory;innovation;Innovation Corps;Intervention;Interview;irritation;Lead;Measurement;Mechanics;member;Methods;Modality;Monitor;monitoring device;Motion;Myocardial;nanowire;natural antimicrobial;next generation;novel;Operative Surgical Procedures;Pathogenicity;Patients;Performance;personalized health care;Persons;Phase;Physicians;Play;Polylysine;Porosity;Printing;Process;programs;Property;Pruritus;PSSO3;Public Health;rational design;Reaction;Recovery;Research;Role;Science;sensor;Signal Transduction;Silver;Skin;skin irritation;Sleep;smart watch;Stress;System;Technology;Testing;Time;Transducers;usability;user-friendly;vibration;wearable device;wound care;wound healing

PROJECT_TITLE: Multifunctional Porous Soft Materials for User-Friendly Skin-Interfaced Bimodal Cardiac Patches with Long-Term Biocompatibility and Antimicrobial Property

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE The process of somatic hypermutation alters antibody genes and is critical for effective vaccine responses and for the production of antibodies that provide strong protection against infections. We will determine the mechanisms and proteins that allow the somatic hypermutation machinery to act efficiently on antibody genes and how these mechanisms and proteins determine which areas of the human genome are susceptible to genetic damage by this same machinery. These experiments will provide a better understanding of the mechanisms that allow for effective immune responses and of the causes of chromosomal aberrations that are the hallmarks of cancer, particularly B cell lymphomas and leukemias.

PI_NAMEs: SCHATZ, DAVID G. (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: activation-induced cytidine deaminase;Acute;Address;Affinity;Antibodies;Antibody Affinity;Antibody Formation;Architecture;Area;Automobile Driving;B lymphoid malignancy;B-Cell Lymphomas;B-Lymphocytes;BCL6 gene;Binding;Biological Assay;Cell Cycle Regulation;Cell Line;Cell Proliferation;Cell Survival;Cells;Chromatin;Chromatin Loop;Chromosomal translocation;Chromosome abnormality;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;CRISPR screen;Cytidine;Deamination;Detection;detection assay;Development;Disease;DNA;DNA Repair;DNA-Directed RNA Polymerase;Elements;Epigenetic Process;essays;experimental study;Gene Activation;gene discovery;Gene Targeting;Generations;Genes;Genetic;Genetic Screening;Genetic Transcription;Genome;Genome Mappings;genome-wide;genome-wide analysis;Genomic Instability;genomic locus;Genomics;Goals;Grant;Human Cell Line;Human Genome;Humoral Immunities;Immune response;Immunoglobulin Class Switching;Immunoglobulin Gene Rearrangement;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;Immunoglobulins;in vivo;Infection;Kinetics;Knock-out;Label;leukemia/lymphoma;Link;Malignant Neoplasms;Maps;Measurement;Mediating;Methodology;Methods;Modeling;Modification;Mus;Mutation;new technology;novel;Nuclear;overexpression;pathogen;Phase;Physical condensation;Point Mutation;Polymerase;Predisposition;Process;Proteins;Proteomics;rapid test;Reaction;reconstitution;Reporting;Research;Resolution;Role;Signal Transduction;Single-Stranded DNA;Site;Structure of germinal center of lymph node;System;TCF3 gene;Technology;Testing;Time;transcription factor;transcriptomics;tumorigenesis;vaccine efficacy;vaccine response;whole genome;Work;YY1 Transcription Factor

PROJECT_TITLE: Targeting of somatic hypermutation in the genome

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Patient Safety;Serious Mental Illness

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Electroconvulsive therapy (ECT) is the most effective therapy for adults with major depression; however, some patients fail to respond despite an adequate trial, and ECT can produce negative cognitive effects. In this revised four site, prospective study we propose the first investigation of ECT outcome integrating multiple types of data including clinical and cognitive measures, whole-brain neuroimaging, EEG, and E-field modeling to establish the mechanisms underlying ECT-induced antidepressant response (response biomarkers) and negative cognitive effects (safety biomarkers). Using this approach in patients with major depressive disorder (n = 230), we will confirm the “sweet spot” of ECT dosing in order to maximize antidepressant benefit and cognitive safety.

PI_NAMEs: MCCLINTOCK, SHAWN M (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Acute;Address;Adult;Adverse effects;Algorithms;Amnesia;Anatomy;anti-depressive agents;Biological Markers;biomarker identification;Blood flow;Brain;Clinical;Clinical Research;Cognitive;cognitive benefits;Collaborations;Corpus striatum structure;Data;Disease remission;Disfluent;Dissociation;Dose;effective therapy;electric field;Electroconvulsive Therapy;Electroencephalography;Ensure;Executive Dysfunction;executive function;follow-up;Functional Magnetic Resonance Imaging;Hippocampus;Image;imaging study;Impaired cognition;improved;Individual;Intervention;Investigation;Knowledge;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;magnetic seizure therapy;Major Depressive Disorder;Measures;Medial;meter;Methodology;Methods;Modeling;multiple data types;National Institute of Mental Health;neuroimaging;Neuronal Plasticity;noninvasive brain stimulation;Outcome;Patient-Focused Outcomes;Patients;Phenotype;Prefrontal Cortex;Process;Prospective Studies;Protocols documentation;Public Health;Research Infrastructure;response;response biomarker;Safety;Sample Size;Seizures;side effect;Site;Spottings;Standardization;Structure;System;Testing;Thalamic structure;therapy outcome;Time;verbal;Weight

PROJECT_TITLE: 4/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MILWAUKEE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Chemokines and their cell-surface receptors form a network of signaling proteins that guide the homing and migration of white blood cells, stem cells and metastatic cancer cells to specific organs and tissues. These distinct and overlapping processes are controlled by the coordinated and non-redundant effects of dozens of different chemokine-receptor pairs, despite the extremely high similarity of all 46 human chemokines and an equivalent level of similarity for the 23 receptors. Our goal is to use advanced computational tools and experimental studies to decipher the ‘chemokine code’ that determines which receptor-ligand combinations orchestrate cell migration in the human body.

PI_NAMEs: VOLKMAN, BRIAN F (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Address;Animal Model;Area;Autoimmune Diseases;Binding;Binding Sites;Biological;Biological Models;Bone Marrow;cancer cell;Cardiovascular Diseases;CCL20 gene;CCR5 gene;CCR6 gene;cell motility;Cell Physiology;Cell Surface Receptors;chemokine;chemokine receptor;Classification Scheme;Clinical;Code;Collection;Complex;computerized tools;Crystallization;CXCL11 gene;CXCR3 gene;CXCR4 gene;CXCR4 Receptors;design;Development;dimer;Disease;Disseminated Malignant Neoplasm;drug development;Drug Targeting;Engineering;Erythrocytes;Erythroid Cells;experimental study;Extracellular Matrix;Family;FDA approved;Foundations;Funding;G-Protein-Coupled Receptors;Glycosaminoglycans;Goals;Hematopoiesis;hematopoietic stem cell formation;hematopoietic stem cell niche;HIV/AIDS;Homing;Human;Human body;immune function;Individual;Inflammation;Inflammatory;inhibitor;Leukocytes;Ligands;Malaria;Malignant Neoplasms;Measures;Membrane;migration;Modeling;Molecular;molecular sequence database;N-terminal;Organ;Parasites;Pharmaceutical Preparations;Plasmodium vivax;Play;Process;Program Development;Protein Secretion;Proteins;receptor;Reporting;Research;Resolution;Role;scavenger receptor;Sequence Analysis;Signal Transduction;Signaling Protein;small molecule;Specificity;stem cells;Stromal Cell-Derived Factor 1;Structure;Surface;System;Testing;Therapeutic;Tissues;tumor progression;tyrosine O-sulfate;Variant;Work;wound healing

PROJECT_TITLE: Structural Basis for Chemokine Function

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Anxiety Disorders;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Rehabilitation;Serious Mental Illness

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARATIVE: Toward Connectomic Deep Brain Stimulation in Obsessive Compulsive Disorder Obsessive Compulsive Disorder is a leading cause of disability worldwide and identifying the brain networks causally involved in the disease will lead to optimized treatment in deep brain stimulation. Here, we leverage a technique recently developed by our group to identify the networks causally involved in mediating symptomatic relief based on a unique combination of deep brain stimulation and maps of human brain connectivity. Completion of this project will provide a clear framework to carry out optimized, symptom-specific and circuit- based deep brain stimulation for patients with obsessive compulsive disorder.

PI_NAMEs: FOX, MICHAEL D (contact)

PROJECT_TERMS: Address;Anxiety;Atlases;Brain;Brain region;burden of illness;Classification;Clinical;clinical practice;clinical predictors;Clinical Trials;cohort;common symptom;comorbidity;compulsion;connectome;connectome data;conventional therapy;Data;Data Analyses;Data Set;Databases;Deep Brain Stimulation;design;design verification;Diffusion;disability;Disease;Disease remission;Future;Goals;Human;improved;Individual;Individual Differences;individual patient;interest;Lead;Link;Location;Maps;Measures;Mediating;Mental Depression;Mental disorders;Methods;Modality;Modeling;Nature;neuroregulation;novel;Obsession;Obsessive compulsive behavior;Obsessive-Compulsive Disorder;Operative Surgical Procedures;Outcome;Patients;Performance;predictive modeling;Procedures;prospective;Publishing;Refractory;Research;response;Rest;Sampling;Scanning;secondary analysis;Site;symptomatic improvement;Symptoms;Techniques;Testing;Training;Translating;treatment optimization;Validation

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PATHOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Repeated exposure to the inhalant anesthetic sevoflurane in infancy impacts cognitive and emotional development in rhesus monkey model, which has implications for childhood anesthetic exposure in humans. This project will test whether changes in mitochondrial structure and/or loss of synapses may account for those changes. We will then evaluate whether R(+)pramipexole (a mitochondrial protectant) given prior to anesthesia exposure can prevent the behavioral and neural changes associated with repeated sevoflurane exposure.

PI_NAMEs: ALVARADO, MARIA C;BAXTER, MARK G (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: 3 year old;Address;Adolescent;Adult;Adverse effects;Age;Anesthesia procedures;Anesthetics;Animal Model;anxiety-related behavior;Apoptosis;Attenuated;Award;Behavior;Behavioral;behavioral impairment;Brain;Central Nervous System;Child;Childhood;Clinical;Clinical Research;clinically relevant;Cognitive;cognitive change;cognitive development;comparison control;density;Development;Dopamine Agonists;Dopamine Receptor;early childhood;Electrons;Elements;Emotional;enantiomer;Euthanasia;experimental study;Exposure to;Free Radicals;General Anesthesia;General anesthetic drugs;Generations;Goals;Hippocampus;Hour;Human;Impaired cognition;Impairment;improved;infancy;Infant;Inhalant dose form;Inhalation Anesthetics;Injections;Lead;Life;Link;Long-Term Effects;Macaca mulatta;memory recognition;Microscopic;Mitochondria;mitochondrial dysfunction;Modeling;Monkeys;Morphology;Neonatal;Nervous System;neural;neurobehavioral;Neurobiology;Neurocognitive;Neurocognitive Deficit;Neurons;neurotoxicity;Neurotoxins;nonhuman primate;Observational Study;Operative Surgical Procedures;Outcome;Oxidative Stress;Pharmaceutical Preparations;Physiology;postnatal;pramipexol;preclinical study;Prefrontal Cortex;presynaptic;prevent;Preventive treatment;Primates;programs;Prospective Studies;Protocols documentation;Research;Risk;Rodent;sedative;sevoflurane;sex;Stereoisomer;Structure;Synapses;Testing;Time;Tissue Banks;tissue preparation;Visual impairment

PROJECT_TITLE: Mitochondrial Protection to Prevent Neurobehavioral Changes after Postnatal Anesthesia

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ITHACA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE  This proposal investigates the molecular mechanisms of adaptor-mediated ubiquitination using the yeast Nedd4 E3 ligase Rsp5 and ART family adaptors as the model ubiquitination platform. Delineating the physiological function of adaptors in substrate ubiquitination will reveal highly original mechanistic features of the ubiquitination cascade. Results from our proposed studies will further foster our understanding of human diseases caused by defects in ubiquitination and will forge new potential trails for therapeutic development.

PI_NAMEs: EMR, SCOTT D;MAO, YUXIN  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Adaptor Signaling Protein;Amino Acids;Architecture;Arrestins;Autophagocytosis;Binding;Binding Sites;Biological Assay;C-terminal;C2 Domain;Cell Cycle;Cell membrane;Cell Physiology;Cells;Collaborations;Complex;Cryoelectron Microscopy;Crystallography;Data;Defect;Distal;DNA Repair;Down-Regulation;Endocytosis;Enzymes;Eukaryota;Evolution;Family;Family member;forging;Fostering;Genetic Transcription;Goals;human disease;Immune response;In Vitro;in vivo;interest;Ligase;Link;Lysine;Maintenance;Malignant Neoplasms;Mammals;Mediating;member;Membrane;Membrane Proteins;Methionine;Modeling;Modification;Molecular;N-terminal;Nature;Neurodegenerative Disorders;PHEMX gene;Physiological;Play;Post-Translational Protein Processing;Process;protein degradation;protein function;Proteins;proteostasis;Quality Control;recruit;Research;Role;Signal Transduction;Site;Specificity;System;Testing;therapeutic development;therapeutic target;trafficking;UBD protein;Ubiquitin;Ubiquitin family;ubiquitin ligase;Ubiquitin-Activating Enzymes;Ubiquitin-Conjugating Enzymes;ubiquitin-protein ligase;Ubiquitination;Yeasts

PROJECT_TITLE: Di-ubiquitin modification of ubiquitin ligase adaptors in membrane protein downregulation

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Complementary and Integrative Health;Dietary Supplements;Nanotechnology;Neurosciences;Nutrition;Prevention;Rare Diseases

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Brain chronic inflammation is a hallmark of the aging process, and promotes the progression of many brain diseases, and there is currently no approved therapy for preventing brain chronic inflammation. The focus of this application is to determine the molecular mechanism through which tiny nanoparticles derived from diet can interact with brain macrophages to inhibit brain inflammation. Defining these underlying mechanisms will provide a strategy for prevention/treatment of brain aging, and thus improve the health status.

PI_NAMEs: ZHANG, HUANG-GE  (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Acids;Affect;Aging;aging brain;aging process;Bacteria;Binding;Biological;blood-brain barrier crossing;Brain;Brain Diseases;brain tissue;c-myc Genes;Calmodulin;CD11 Antigens;Cell Separation;Cells;Chronic;Clinical;clinical application;Consumption;cytokine;Data;design;Development;Diet;Disease;Edible Plants;Encephalitis;exosome;Foundations;Garlic;good diet;gut-brain axis;hallmarks of aging;Health Status;Human;Immune Tolerance;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory;insight;Interleukin-1 beta;Interleukin-10;Interleukin-6;Intervention;Intestines;Knock-out;Knowledge;Lipids;Macrophage;Mediating;Microglia;Modeling;Molecular;murine colitis;Mus;nanoparticle;Neuroimmune;neuroinflammation;new therapeutic target;old mice;Oral;Oral Administration;Pathway interactions;Phosphatidic Acid;Physiological;Physiology;Plants;prebiotics;prevent;Prevention;Prevention strategy;Probiotics;Process;Production;protective effect;Protein Analysis;protein expression;Proteins;Publishing;RNA;Role;Small RNA;Sorting;Structure of thyroid parafollicular cell;Testing;Therapeutic;TNF gene;transcriptome sequencing;translational study;Untranslated RNA;v-myc Gene

PROJECT_TITLE: Mechanisms underlying edible exosome-like nanoparticles for prevention of brain inflammation

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology;Lung;Orphan Drug;Rare Diseases;Sickle Cell Disease

ORG_DEPT: SURGERY

PHR: Project Narrative  People with sickle cell disease suffer from hemolytic anemia, and poor vascular function that can increase vasocongestion. Acute vaso-occlusive crises can occur in anywhere in the body, and are capable of inducing chronic organ injury, stroke, neurological injury and death. This application investigates how sickle cell disease impairs vascular function and designs novel therapies to improve vascular function and reduce vasocongestion.

PI_NAMEs: PRITCHARD, KIRKWOOD ARTHUR (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Acute;Amides;Anti-Inflammatory Agents;Antioxidants;Binding;Biological Availability;Blood Vessels;Cells;Cessation of life;Chronic;Clinical;Complex;Consumption;Data;design;Disease;Endothelial Cells;Enzymes;experimental study;Gene Expression;gene product;Genes;Goals;Hemoglobin;Hemolytic Anemia;HMGB1 gene;Homozygote;Hypoxia;Impairment;improved;Infiltration;Inflammation;Inflammatory;inhibitor;Injury;Knock-out;knockout gene;Knockout Mice;liver injury;Lung;Lung Diseases;Mediating;Mediator;mimetics;Molecular;Mouse Strains;multimodality;Mus;Myeloid Cells;Necrosis;Nervous System Trauma;neutrophil;Nitric Oxide;novel;novel therapeutics;organ injury;Outcome;Oxidants;Oxidative Stress;Oxidoreductase;Pathway interactions;Pattern;Peptides;Permeability;Peroxidases;Persons;Pharmacologic Substance;Pharmacology;Physiology;Predisposition;Production;Protein S;Pulmonary artery structure;recruit;Relaxation;Reporting;Research;Role;S-Nitrosoglutathione;S-Nitrosothiols;Sickle Cell;Sickle Cell Anemia;Sickle Hemoglobin;sickling;Stroke;suicide inhibitor;System;Tamoxifen;Tertiary Protein Structure;Testing;Vascular Diseases;vaso-occlusive crisis;Vasodilation

PROJECT_TITLE: Mechanisms of Inflammation in Sickle Cell Disease

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ORG_CITY: STONY BROOK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative This project is relevant to public health, because the understanding of how conformational dynamics affect the regulation, allosteric modulation, ligand binding kinetics and drug specificity of protein kinases is expected to increase understanding of disease-relevant kinase signaling pathways. The project aims to advance this fundamental knowledge.

PI_NAMEs: SEELIGER, MARKUS A (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Affect;Affinity;Binding;Biological Assay;Biological Process;Biology;Catalytic Domain;Cells;Chemicals;Clinical;Collaborations;Computer Models;Computing Methodologies;Conserved Sequence;Cyclic AMP-Dependent Protein Kinases;Data;Data Set;design;Development;Disease;Dissociation;Drug Modelings;Drug resistance;Enzymes;Family;Foundations;Goals;Health;Human;In Vitro;inhibitor;kinase inhibitor;Kinetics;Knowledge;Ligand Binding;Malignant Neoplasms;Medicine;Molecular;Molecular Conformation;Mutation;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phenotype;Phosphotransferases;pressure;Process;Productivity;Protein Engineering;Protein Kinase;protein structure;Protein Tyrosine Kinase;Proteins;Public Health;Regulation;Research;resistance mechanism;resistance mutation;Roentgen Rays;Role;Signal Pathway;Signal Transduction;Specificity;src-Family Kinases;Testing;therapeutic target

PROJECT_TITLE: Dynamics of Ligand Binding and Protein Kinase Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: DK

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE There is a tremendous need to provide trainees with the fundamental knowledge pertaining to metabolism, omics approaches, and factors that contribute to host physiology. We propose a new predoctoral training program to train young scientists in the use of novel and cutting-edge tools to study metabolic phenotypes in a cross- disciplinary environment. The trainees emerging from the training program will be leaders in the field in both academic and industrial settings.

PI_NAMEs: PATTERSON, ANDREW  (contact);PERDEW, GARY H.

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: Integrative Analysis of Metabolic Phenotypes (IAMP) Predoctoral Training Program

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: Newark

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE While nanoparticle therapeutics are being used clinically to manage diseases ranging from cancer to COVID-19, their performance is still hindered by difficulties surpassing immune, vascular, and tissue barriers. This MIRA will probe nano/bio interactions and evaluate new approaches to understand and overcome the biological barriers to nanomedicine, with the goal of improving nanoparticle delivery efficiency, safety, and therapeutic efficacy. By addressing knowledge gaps surrounding nanoparticles’ interactions with biological systems, this work will boost the clinical performance of nanomedicines to improve patient outcomes and quality of life.

PI_NAMEs: DAY, EMILY S (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Antibodies;Architecture;Artificial nanoparticles;Binding;Biological;biological systems;Blood Vessels;Cells;Clinical;COVID-19;Development;Disease;Disease Management;Disease Progression;Disparity;extracellular;Extracellular Matrix;Extravasation;Fetal health;Funding;Genes;Goals;Healthcare;Hematological Disease;Immune;immune clearance;improved;Inflammation;Knowledge;Lead;Light;Macrophage;Malignant Neoplasms;Mediating;Membrane;Mucous body substance;nano;nanomedicine;nanoparticle;nanoparticle delivery;novel strategies;Nucleic Acids;Patient-Focused Outcomes;Penetration;Performance;Population Heterogeneity;pre-clinical;Precision therapeutics;programs;Property;Proteins;Quality of life;reproductive;Research;response;Role;Safety;Technology;Therapeutic;therapeutic nanoparticles;Tissues;tool;Treatment Efficacy;vaginal microbiome;Whole Organism;Work

PROJECT_TITLE: Probing nano/bio interactions to understand and overcome biological barriers limiting nanomedicine

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: MADISON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: NARRATIVE Tuberculosis is the leading cause of death due to infectious disease worldwide. The goal of this proposal is to better understand evolution of the causative agent, Mycobacterium tuberculosis, in order to enable development of more effective strategies to treat and control TB.

PI_NAMEs: PEPPERELL, CAITLIN S (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: acquired drug resistance;Affect;airway epithelium;antibiotic tolerance;Antibiotics;Architecture;assault;Autopsy;Bacteria;Binding Sites;candidate identification;Cause of Death;Cell Enlargement;Cells;Clinical;Collection;Communicable Diseases;Complex;Control Locus;Data;Development;Disease;Dose;Drug resistance;Environment;Epigenetic Process;Evolution;Exhibits;experience;experimental analysis;experimental study;Exposure to;Gene Dosage;Gene Expression Regulation;Genetic;Genetic Transcription;genetic variant;Genetic Variation;genomic data;genomic locus;Genomics;Goals;Growth;Human;Hypoxia;In Vitro;Individual;Infection;insight;Lesion;Mediating;Microbial Biofilms;Molecular;Mutation;Mycobacterium tuberculosis;neutrophil;novel;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathologic;Patients;Persons;Phenotype;polymicrobial biofilm;Population;Regimen;Research;resistant strain;Resources;response;Roentgen Rays;Role;Serial Passage;Shapes;Source;stressor;System;Testing;tool;transcription factor;Treatment Failure;Tuberculosis;tuberculosis treatment;Variant;Work

PROJECT_TITLE: Drifting to victory: resolving the paradox of M. tuberculosis evolution

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Primary Health Care;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Utilization of new long-acting medications for opioid use disorder (OUD) is low despite major morbidity and mortality due to OUD in the United States. The proposed research uses health insurance claims data and qualitative interviews to study clinician behavior around adoption and scale-up of long-acting medications for OUD. The information learned from the study is relevant to public health efforts to increase access to and utilization of these life-saving medications; therefore, it is relevant to the part of NIDA’s mission of developing and testing strategies for implementing evidence-based treatments.

PI_NAMEs: SHOVER, CHELSEA LEIGH (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: addiction;Adopted;Adoption;AIDS prevention;Award;Buprenorphine;California;career;Caring;Clinic;Clinical;Clinical Trials;Communication;Communities;Complex;Consolidated Framework for Implementation Research;Crime;Data;Data Set;Diffuse Pattern;disease transmission;Dose;Educational workshop;Epidemiologist;Epidemiology;Evidence based treatment;experience;follow-up;Formularies;Formulation;Frequencies;Geography;Goals;Grant;Health Insurance;Health Services;Health Services Research;Health system;illicit opioid;Implant;implementation science;implementation study;improved;Individual;Injectable;Injections;Insurance;insurance claims;Intervention;Interview;K-Series Research Career Programs;large datasets;Learning;Life;longitudinal analysis;Maintenance;Medicaid;medical specialties;Medicare;medication for opioid use disorder;Medicine;Mentors;Mentorship;Methadone;Mission;Modality;Morbidity - disease rate;mortality;Motivation;Naltrexone;National Institute of Drug Abuse;novel;opioid epidemic;opioid overdose;opioid use;opioid use disorder;Oral;Outpatients;Pain;Patient Selection;patient-level barriers;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Physicians;Policies;Population;prevent;Primary Care;primary care clinician;Primary Care Physician;Principal Investigator;Procedures;Provider;provider behavior;Psychiatrist;Psychiatry;Public Health;Qualitative Research;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recovery;Research;Research Personnel;Resources;scale up;service intervention;skills;structural determinants;Structure;substance use;Substance Use Disorder;substance use treatment;symposium;System;system-level barriers;systemic barrier;tenure track;Testing;Time;Training;Treatment outcome;United States;United States Food and Drug Administration;uptake;Veterans Health Administration;Visit;willingness;Writing

PROJECT_TITLE: Adoption and scale-up of long-acting medications for opioid use disorder by U.S. clinicians.

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative We have recently applied multiplex genome editing to reduce the alloreactivity of vascular smooth muscle cells and endothelial cells derived from human pluripotent stem cells by ablating the expression of MHC Class Ia and II proteins, while upregulating immunomodulatory factors, PD-L1, HLA-G, and CD47. Further, we have also developed new engineering approaches for the fabrication of mechanically robust, free-standing, ultrathin collagen sheets and related manufacturing tools for the scalable production of engineered living blood vessels. We believe that breakthroughs by the investigative team in genome editing, stem cell biology, materials science, and microfabrication offer an opportunity to evaluate a variety of tolerogenic strategies for the engineering of living blood vessels that evade alloimmune rejection.

PI_NAMEs: CHAIKOF, ELLIOT  (contact);MEISSNER, TORSTEN BJOERN

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Ablation;Allogenic;Aneurysm;Arteries;Biochemical;biodegradable polymer;Biological;Biomechanics;Blood Vessels;CD47 gene;Cell Wall;Cells;Chemicals;Collagen;Collagen Fiber;Collagen Fibril;design;differentiation protocol;Elastin;Elements;Endothelial Cells;Engineering;Extracellular Matrix;fabrication;Failure;genome editing;HLA G antigen;HLA-A gene;Homing;Human;human pluripotent stem cell;hydrodynamic flow;Immune Evasion;Immune system;Immunoassay;immunodeficiency;immunogenicity;immunoregulation;Implant;implantation;In Vitro;in vivo;Infiltration;innovation;large scale production;Macrophage;manufacture;materials science;Mechanics;meter;Microfabrication;Morphology;Mus;Natural Killer Cells;Operative Surgical Procedures;Patients;Phase;Phenotype;Physiological;Process;Production;programmed cell death ligand 1;Property;Proteins;Protocols documentation;Rattus;reconstitution;Reporting;Research Personnel;response;Risk;scaffold;Smooth Muscle Myocytes;Source;stem cell biology;stem cells;Stenosis;Structure;T-Lymphocyte;Techniques;Thick;Tissue Engineering;tool;Vascular Smooth Muscle;vascular tissue engineering

PROJECT_TITLE: Immunoevasive Engineered Living Blood Vessels


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

PHR: The surfaces of all mammalian cells are covered with glycosylated molecules. We develop chemical biology methods to study the function of glycosylated molecules and are working to identify genes that regulate the production of glycosylated molecules. Understanding the regulation and function of glycosylated molecules has relevance to human physiology, including susceptibility to infectious diseases and to cancer.

PI_NAMEs: KOHLER, JENNIFER J (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TITLE: Function and regulation of epithelial glycosylation


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SACRAMENTO

ORG_NAME: CALIFORNIA STATE UNIVERSITY SACRAMENTO

PHR: PROJECT NARRATIVE We propose to automate objective differential diagnoses of middle-ear and conductive pathologies by taking advantage of pattern-recognition and classification capabilities of machine learning to infer details about the middle-ear status from wideband tympanometry clinical data. We will train an inference neural network with synthetic data obtained from validated and tuned computational models of the middle ear in the first step, which reduces the need for a large clinical dataset from pathological ears, and then retrain the neural network using a limited set of labeled clinical data using a concept called transfer learning. The trained neural network will allow for an objective and fast identification of conductive pathologies in individual ears to improve surgical specificity, minimize unnecessary exploratory surgery and imaging, and provide an objective clinical means of postoperative monitoring.

PI_NAMEs: MOTALLEBZADEH, HAMID  (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Affect;Age;age related changes;Air;Anatomy;Audiology;Behavior;bone;Characteristics;Classification;Clinical;Clinical Data;Clinical Research;Complex;Computer Models;computerized data processing;Conductive hearing loss;cost;cost effective;Data;Data Set;Diagnosis;Diagnostic;diagnostic criteria;Differential Diagnosis;dimension reduction;Ear;electric impedance;Elements;Exhibits;experience;External auditory canal;Eye;Feasibility Studies;feature extraction;feature selection;feeding;Frequencies;Geometry;Goals;hands-on learning;hearing impairment;Hearing Tests;Human;Image;image registration;improved;Individual;insight;Knowledge;Label;large datasets;Ligaments;Literature;Machine Learning;machine learning algorithm;Manuals;Maps;Measurement;Measures;Methodology;Methods;microCT;middle ear;Mining;Modeling;Monitor;neural network;neural network architecture;Noise;noninvasive diagnosis;Normal Range;Operative Surgical Procedures;Otosclerosis;Outcome;Outcome Study;Output;Pathologic;Pathology;Patients;Pattern Recognition;Performance;Physicians;Physiological;Population;Postoperative Period;Preparation;pressure;Probability;Process;Property;Randomized;Reporting;response;Risk;Roentgen Rays;sample fixation;Sampling;Series;simulation;Specificity;Specimen;Stapes;Statistical Data Interpretation;stem;Structure;Surgical Disarticulation;Symptoms;synthetic data;Techniques;Testing;tool;Training;training data;transfer learning;Trauma;Tympanometry;Uncertainty;Variant;X-Ray Computed Tomography

PROJECT_TITLE: Objective and noninvasive diagnosis of middle-ear and conductive pathologies using simulation-based inference and transfer learning applied to clinical data

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Overview of the Proposed Resource – Narrative The goal of the Center for Mesoscale Mapping is to drive the convergence of microscopic- and macroscopic- scale evaluation of brain structure and function for human translational neuroscience, by developing and applying tools to study the spatial distribution and temporal orchestration of mesoscopic events in the human brain. Our Collaborators will, through a dynamic “push-pull” relationship, provide unique problems which drive the development of these tools, and in return guide us in the design and optimization of our toolbox for practical use in a variety of normal and disease settings.

PI_NAMEs: ROSEN, BRUCE R (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Alzheimer's Disease;Anatomic Models;Basic Science;Biological;Brain;brain magnetic resonance imaging;Brain Stem;Cell Nucleus;Cerebral Palsy;cognitive neuroscience;Communities;Computer Models;Computer software;Consensus;Data;Data Set;data space;deep learning;design;Development;Devices;Diffusion;Dimensions;Disease;Educational process of instructing;Educational workshop;electric field;Electroencephalography;Electromagnetics;Electrophysiology (science);Epilepsy;Evaluation;Event;Fiber;Frequencies;frontier;Functional Magnetic Resonance Imaging;Generations;Goals;Histologic;Human;human disease;human imaging;Image;improved;in vivo;in vivo evaluation;industry partner;instrumentation;Investigation;Link;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Maps;Measures;Mental Depression;Mental disorders;meter;Microscopic;Mind;model building;Modeling;Molecular;Morphologic artifacts;Motion;Multiple Sclerosis;Nervous System Disorder;neural;neuroimaging;Neurons;neuropathology;Neurosciences;novel;open source;Performance;Peripheral Nerve Stimulation;post-doctoral training;pre-doctoral;Property;Publications;reconstruction;Research Personnel;Resolution;Resources;Respiration;response;Scanning;Services;Signal Transduction;Sleep Disorders;Slice;Spatial Distribution;spatiotemporal;Structure;Surface;System;Techniques;Technology;Time;tool;tool development;Training;Training Programs;Transcranial magnetic stimulation;translational neuroscience;usability;Visualization;web based software;white matter;Work

PROJECT_TITLE: Center for Mesoscale Mapping


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Rural Health;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE This proposal is in response to FOA RFA-ES-20-018. The proposal aims to identify shared genetic pathways that promote the establishment of persistent neurotoxic state for individuals residing in northern Indiana via in vitro functional genomics. We will select toxins via exposure history and combine subject-specific human induced pluripotent stem cell, as well as zebrafish and C. elegans animal models, to understand gene by environment induced persistent neurotoxicity.

PI_NAMEs: BOWMAN, AARON B (contact);YUAN, CHONGLI ;ZHANG, MIN

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Acute;Adult;Age;age related;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Animal Model;Barker Hypothesis;Bioinformatics;Birth;Blood Cells;Caenorhabditis elegans;Cells;cellular imaging;Chromatin;cohort;community academic partnership;Data;data mining;Development;Disease;disorder risk;early life exposure;Elderly;Environment;environmental chemical;Environmental Exposure;Environmental Hazards;Environmental Risk Factor;Epigenetic Process;epigenetic profiling;Exhibits;exposed human population;Exposure to;Fibrinogen;functional genomics;gene environment interaction;Gene Expression;Genes;Genetic;Genetic Diseases;Genetic Models;Genetic Risk;genetic risk factor;genome-wide;Genomic approach;Genotype;Geographic Locations;Hazard Identification;healthspan;healthy aging;Human;human disease;human induced pluripotent stem cells;Impaired cognition;Impairment;In Vitro;in vitro Model;in vivo;Incidence;Indiana;Individual;individual variation;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;innovation;late life;Lead;Life;Link;Metals;Midbrain structure;model organism;Modeling;motor disorder;motor impairment;multidimensional data;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neurotoxic;neurotoxicity;Neurotoxins;next generation sequencing;novel;Outcome Measure;Paraquat;Parkinson Disease;pathogen;Pathologic;Pathway Analysis;Pathway interactions;Patients;Persons;Pesticides;Phenotype;pollutant;Population;Population Database;Predisposition;Probability;Process;programs;Property;public database;Rapid screening;Recording of previous events;recruit;Research Design;resilience;response;Risk;Role;Rural;Rural Population;Same-sex;Sampling;sex;Siblings;Signal Pathway;Signal Transduction;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Statistical Methods;stem;stem cell model;Testing;Time;Toxic Environmental Substances;toxicant;toxicant interaction;Toxicology;Toxin;transcription factor;transcriptomics;virulence gene;Work;Zebrafish

PROJECT_TITLE: Modeling functional genomics of susceptibility to the persistent effects of environmental toxins in an elderly rural Indiana neurodegenerative cohort


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Public Health Relevance Statement The overriding goal of this proposal is to identify and characterize mouse atherosclerosis modifier genes and gain insight into their mechanism of action. These results may yield novel insights into the molecular mechanisms that underlie human atherosclerosis, and thus provide the foundation for novel improvements in the diagnosis, treatment, and prevention of coronary artery disease, a leading cause of morbidity and mortality in the United States.

PI_NAMEs: SMITH, JONATHAN D (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: 3' Untranslated Regions;acetyl-LDL;Affect;Alleles;Antisense Oligonucleotides;Apolipoprotein E;Area;Atherosclerosis;Autophagocytosis;Bioinformatics;Bone Marrow;Candidate Disease Gene;Cardiovascular Diseases;causal variant;Cell Culture Techniques;cell type;Cessation of life;Cholesterol;Cholesterol Esters;Cholesterol Homeostasis;Chromosome 2;Chromosomes;Congenic Mice;Coronary Arteriosclerosis;CRISPR/Cas technology;Data;DBA/2 Mouse;density;Development;Diagnosis;embryonic stem cell;Endothelial Cells;Exons;Foam Cells;Foundations;gene discovery;Gene Modified;gene-editing approach;Genes;Genetic;genetic approach;genetic variant;Genetic Variation;genome wide association study;genomic locus;Genomics;Genotype;Goals;Health;Heart Diseases;Heritability;Human;Human Genome;improved;In Vitro;in vitro activity;in vitro Model;in vivo;Incidence;Incubated;Inflammasome;Inflammation;innovation;insight;interest;Knowledge;Lesion;Leukotriene B4;Lipids;Low Density Lipoprotein Receptor;Lysosomes;Macrophage;Manuscripts;Maps;Mediating;men;Messenger RNA;Metabolism;Methods;Molecular;Morbidity - disease rate;mortality;mouse genetics;mouse model;Mouse Strains;Mus;Names;new therapeutic target;novel;novel diagnostics;novel therapeutics;Obesity;Pathway interactions;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Predisposition;Preparation;prevent;Prevention;Program Research Project Grants;Proteins;public health relevance;Publishing;Quantitative Trait Loci;Recombinants;Resistance;Resolution;Risk;Risk Assessment;Risk Factors;RNA Splicing;Sequence Deletion;single-cell RNA sequencing;sterol O-acyltransferase 1;Testing;Tissues;trait;transcriptomics;United States;Validation;Variant;Woman;Work

PROJECT_TITLE: Genetic modifiers of atherosclerosis and macrophage phenotypes

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Chronic Pain;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Women's Health Research;Wound Healing and Care

ORG_CITY: HERSHEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE Pain from traumatic burn injuries is likely the most severe form of pain imaginable, yet reports suggest that burn- related pain is currently undertreated. Women report more severe pain and are more likely than men to experience chronic pain following burn injuries. In this proposed program of research, we will investigate the immune and neuroendocrine mechanisms behind these sex differences in pain following traumatic burn injuries.

PI_NAMEs: NYLAND, JENNIFER E. (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Acceleration;Acute Pain;Adrenal Glands;Animal Model;Automobile Driving;Award;Burn injury;chronic pain;Debridement;Development;Excision;experience;Female;Future;Genes;Goals;Hormones;Hyperalgesia;Hypothalamic structure;Immune;Immune response;immunoregulation;Inflammation;Injury;Innate Immune Response;insight;Intervention;Lead;male;Mediator;men;nerve damage;Neurosecretory Systems;novel;Opioid Analgesics;Pain;pain chronification;pain inhibition;pain outcome;pain processing;pain sensitivity;Pathogenesis;Pathway interactions;Pituitary Gland;Play;Positioning Attribute;prevent;Procedures;programs;Reporting;Research;response;response to injury;Role;sex;Sex Differences;Signal Transduction;Stress;Survivors;Thick;Tissues;Trauma;Traumatic injury;Woman;women subjects;wound care

PROJECT_TITLE: Immune and neuroendocrine mediators of sex-differences in pain following traumatic burn injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Human Genome;Infertility;Maternal Health;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Nearly 50% of infertility and recurrent pregnancy loss cases are currently without a genetic explanation. Disruption of retrotransposon activity in the mouse preimplantation embryo leads to altered global protein synthesis, improper uterine implantation that resembles human pregnancy complications and embryonic lethality. This project will adapt powerful proteomics, genetics, bioinformatics and CRISPR/Cas9 genome editing technologies to generate a meaningful understanding of the role of retrotransposon activity in development and disease that will reveal an overlooked and essential form of regulation present in early embryonic development.

PI_NAMEs: MODZELEWSKI, ANDREW JOSEPH (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: 5' Untranslated Regions;Acceleration;Area;Automobile Driving;Bioinformatics;Biological;Biology;Biosensor;blastocyst;career;Cell Cycle;Cell Cycle Progression;Cell division;Cells;Chimerism;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collaborations;Community Developments;Complex;confocal imaging;Consumption;CRISPR/Cas technology;Crowding;Data;Data Set;Defect;Development;Disease;Electroporation;Elements;Embryo;embryo cell;Embryo Transfer;Embryonic Development;Event;Exons;Family;Fertility;gene regulatory network;Gene Structure;Genes;Genetic;genetic manipulation;Genetic Transcription;Genome;genome editing;Glucose;Goals;Health;Homeostasis;Human;Human Genome;Immunofluorescence Immunologic;implantation;In Vitro;in vivo;Individual;Infertility;insight;Knock-out;Knockout Mice;Metabolic;Methods;Monitor;Morula;mouse genome;Mus;Mutation;N-terminal;natural Blastocyst Implantation;Nature;novel;Open Reading Frames;overexpression;Phase;Phenotype;Placenta;placenta previa;Polyadenylation;Positioning Attribute;Pre-Eclampsia;Pre-implantation Embryo Development;Pregnancy;Pregnancy Complications;Pregnancy loss;preimplantation;Process;promoter;Protein Biosynthesis;Protein Isoforms;Proteins;Proteome;Proteomics;Pyruvate;Recurrence;Regulation;Reporting;Research;Retrotransposon;ribosome profiling;RNA;RNA Splicing;Role;Signal Transduction;single cell analysis;Site;Specific qualifier value;Stress;Surveys;Techniques;Technology;Testing;Time;Training;Transcript;transcriptome;transcriptome sequencing;Translations;uterine receptivity;Uterus;Western Blotting;Work

PROJECT_TITLE: The Role of Retrotransposon Activity in Mammalian Pre-Implantation Development

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Neurosciences;Pediatric;Prevention;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Enterovirus D68 is a virus that causes large outbreaks of both respiratory illness and acute flaccid myelitis, a polio-like illness. This career development program will provide training that allows a pediatric physician scientist to develop an independent research career aimed at understanding in detail how the human antibody response modifies the course of enterovirus diseases. This work will inform vaccine design, and the antibodies studied can be used directly in humans as prophylactic and therapeutic agents.

PI_NAMEs: VOGT, MATTHEW R (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acute;acute flaccid myelitis;Adult;Affect;Age;Age Months;Air;airway epithelium;animal model development;Antibodies;Antibody Response;Antibody-mediated protection;Apical;B-Lymphocytes;Back;Biological Models;Breathing;career;career development;Cell Culture Techniques;Cells;Central Nervous System;Central Nervous System Diseases;Cessation of life;Child;Childhood;Circulation;Communicable Diseases;Complement;Cotton Rats;cross reactivity;Deglutition;Disease;disease model;Disease Outbreaks;efficacy evaluation;emerging pathogen;empowerment;Enterovirus;Enterovirus 68;Epithelial Cells;Epitopes;Etiology;experience;Family Picornaviridae;Fever;Funding;Future;Gastrointestinal tract structure;glycosylation;Goals;Health;Hour;Human;Human Characteristics;human monoclonal antibodies;Human poliovirus;human tissue;Immune response;Immunoglobulins;Immunologics;Immunology;in vivo;Incidence;Industry Collaboration;Infection;Infection prevention;Inflammation;Intranasal Administration;intraperitoneal;K-Series Research Career Programs;Kinetics;Limb structure;Liquid substance;Lung;medical schools;Mentors;Microbiology;Modeling;Modification;Monoclonal Antibodies;mouse model;Mucous Membrane;Mus;Muscle;Nervous System Disorder;Neurological Models;neuronal transport;Neuropathogenesis;neutralizing antibody;neutralizing monoclonal antibodies;Newborn Infant;North Carolina;Paralysed;Pathogenesis;pathogenic virus;Pathologic;Pathology;Pathway interactions;Patients;permissiveness;Physicians;Poliomyelitis;polyclonal antibody;preadolescence;Predisposition;prevent;professor;Program Development;programs;prophylactic;receptor;Recovery;Research;Residual state;respiratory;Respiratory Disease;Respiratory Mucosa;respiratory pathogen;Respiratory System;Respiratory Tract Infections;response;Scientist;seropositive;Seroprevalences;Serum;skill acquisition;Surface;targeted treatment;Teenagers;tenure track;Testing;Therapeutic Agents;Tissue Model;tool;Training;Translating;transmission process;United States;Universities;Vaccination;Vaccine Design;Vaccines;Viral Pathogenesis;viral transmission;Virus;Virus Diseases;Work

PROJECT_TITLE: Human antibody modification of enterovirus D68 infection

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ORG_CITY: LIVERMORE

ORG_NAME: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC

PHR: Project Narrative This project will develop new technologies for high-resolution, time-resolved structure determination of membrane proteins by overcoming current challenges in x-ray diffractive imaging of biological samples with x- ray free-electron lasers (XFELs). Membrane proteins perform many critical cellular functions, such as intercellular transport, signaling and enzymatic function, and are medically important—about a third of all human proteins are membrane proteins and account for more than half of all drug targets. Tools for determining the structure and the dynamical behavior of membrane proteins at room temperature with near atomic resolution will greatly improve our knowledge of biomolecular function with direct relevance and impact on biomedicine and public health.

PI_NAMEs: FRANK, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;Area;Behavior;Benchmarking;Biological;biological development;biosecurity;Cell Physiology;Cellular Membrane;Consumption;Cryoelectron Microscopy;cryogenics;Crystallization;Crystallography;data acquisition;Data Set;density;design;Development;Drug Targeting;electric field;Electrodes;Electronics;Electrons;Encapsulated;Environment;European;Film;flexibility;Freezing;Generations;graphene;Health;Human;Hydration status;Image;improved;Investigation;Knowledge;Laboratories;Light;Lipids;Liquid substance;Location;maleic acid;manufacture;Measurement;Medical;Membrane;Membrane Potentials;Membrane Proteins;Methodology;Methods;millisecond;mimetics;Molecular Conformation;nano-objects;nanolipoprotein particles;nanoparticle;new technology;next generation;novel;novel strategies;Physiologic pulse;Polymers;Preparation;protein complex;Protein Dynamics;protein function;protein structure;Proteins;Protons;Public Health;Radiation Dose Unit;Radiation induced damage;Reaction;Reproducibility;Research;Resolution;Roentgen Rays;Sampling;scaffold;Scanning;Science;Signal Transduction;Silicon;Source;spatiotemporal;Speed;structural biology;structural imaging;Structure;Styrenes;Techniques;Technology;technology development;Temperature;Thinness;Time;tool;Transmembrane Domain;Vacuum;Visualization;voltage gated channel;Work;X ray diffraction analysis;X-Ray Crystallography;x-ray free-electron laser;X-Ray Medical Imaging

PROJECT_TITLE: Technology Development for Biological Imaging with XFELs

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: OVERALL: PROJECT NARRATIVE The human immune response to virus infection is remarkably heterogeneous. The COVID-19 pandemic caused by the novel respiratory virus, SARS-CoV-2, revealed major gaps in our understanding of human anti- viral immunity, and the different responses and susceptibilities between individuals based on age, sex, and other factors. This proposed program will advance our understanding of human immune responses to viruses and vaccines by studying tissue sites where immune cells reside and function to obtain a more complete assessment of the factors which control immune protection than can be measured in peripheral blood.

PI_NAMEs: FARBER, DONNA L. (contact);SIMS, PETER ALAN

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: 2019-nCoV;Acute;adaptive immune response;Age;age related;Anti-viral Response;Antibodies;Antigens;antiviral immunity;Area;Award;B-Lymphocytes;Blood;Cell Communication;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Circulation;Clinical;cohort;Collaborations;Communication;Complex;Computational Biology;computerized tools;COVID-19 pandemic;current pandemic;Cytomegalovirus;Data Analyses;data curation;data management;data resource;data sharing;Data Storage and Retrieval;data tools;Dendritic Cells;Disease;effector T cell;Ensure;Female;Frequencies;Gene Expression;genetic signature;Goals;Health;Heterogeneity;high dimensionality;Homeostasis;Human;human tissue;Image;Imaging technology;Immune;immune imaging;immune modulating agents;Immune response;Immunity;Immunology;Immunology procedure;immunomodulatory therapies;In Situ;in vivo;Individual;Infection;Infectious Agent;Infiltration;Influenza;Infrastructure;Innate Immune Response;innovation;insight;Intestines;Learning;Link;Longitudinal cohort;Lung;lymph nodes;Lymphocyte;Lymphoid;Lymphoid Tissue;Macrophage;male;Maps;Measures;migration;Molecular;molecular drug target;Molecular Profiling;mouse model;Mucous Membrane;multiple sclerosis patient;Natural Killer Cells;New York City;novel;novel virus;Occupational activity of managing finances;Organ Donor;Organ Procurements;pathogen;pathogenic virus;Patients;Peripheral;peripheral blood;Population;Predisposition;prevent;programs;protein expression;Protocols documentation;Research;Research Personnel;Resolution;Resources;respiratory virus;response;Role;Sampling;Severity of illness;sex;single cell analysis;single cell genomics;single cell technology;Site;Skin;Specificity;Specimen;Symptoms;System;T-Cell Activation;T-Lymphocyte;Techniques;Tissue Differentiation;tissue resident memory T cell;tissue resource;Tissues;Vaccination;Vaccine Antigen;vaccine immunogenicity;vaccine response;vaccine trial;Vaccines;Viral;Viral Vaccines;Virus;Virus Diseases

PROJECT_TITLE: Human anti-viral immune responses in tissues and circulation


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases

PI_NAMEs: SIMS, PETER ALAN (contact)

PROJECT_TERMS: 2019-nCoV;Activities of Daily Living;Address;Adult;Age;Antibodies;antigen-specific T cells;Antigens;B-Cell Antigen Receptor;Bar Codes;Cell Count;Cell Separation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Circulation;comparative;cost effective;Cytomegalovirus;DNA;Epitopes;experimental study;Flow Cytometry;Funding;Genomic Library;Genomics;Human;Immune;Immune response;Immunologic Receptors;Immunology;Immunophenotyping;indexing;Individual;Infant;Influenza;Joints;Libraries;Link;Maps;Membrane Proteins;Messenger RNA;Microfluidics;multiple omics;Organ Donor;Phenotype;Population;Preparation;protein expression;protein profiling;Proteome;Protocols documentation;Quality Control;Reporting;Research Personnel;Resolution;Resources;Rest;Sampling;SARS-CoV-2 antigen;single cell analysis;single cell genomics;single cell technology;single-cell RNA sequencing;Site;Sorting;Specificity;Stains;Surface;T cell receptor repertoire sequencing;T-Cell Activation;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-Lymphocyte;Technology;Tissue Donors;Tissues;tool;transcriptome;Vaccines;Viral;Virus

PROJECT_TITLE: Single Cell Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Congenital Structural Anomalies;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Vector-Borne Diseases;Zika Virus

PHR: NARRATIVE Pregnant women with Zika virus infection can transmit the virus to their unborn children, which results in mul- tiple birth defects including brain abnormalities, visual abnormalities, and hearing loss. It is important to define the full spectrum of symptoms, disease pathogenesis and early predictors of neurodevelopmental deficits in a controlled setting using a macaque model of Zika virus infection. This grant characterizes sensory and motor neurodevelopment in infant macaques and correlates these outcomes with brain abnormalities found on brain imaging and brain histopathology in order to identify early predictors of neurodevelopmental deficits that can be used to design future human clinical studies.

PI_NAMEs: AUSDERAU, KARLA KAYE;MOHR, EMMA L (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Affect;Age;Age Months;American;Auditory;Behavior assessment;behavioral outcome;Birth;Brain;brain abnormalities;Brain imaging;Brain Pathology;Brain region;brain stem auditory evoked potentials;Cell Nucleus;Cerebral Palsy;Child;Childhood;Clinical Research;Clinical Trials;cohort;Cohort Studies;comparison control;Congenital Abnormality;congenital zika syndrome;Controlled Study;Data;design;Development;Disease;early childhood;Early identification;Early Intervention;Electrophysiology (science);Enrollment;epidemic virus;Fetus;functional outcomes;Funding;Future;Grant;Hearing;hearing impairment;Heterogeneity;Histopathology;Human;in utero;Individual Differences;individual variation;infancy;Infant;Infection Control;Intervention;Investigation;Life;longitudinal design;Macaca;Macaca mulatta;Magnetic Resonance Imaging;Modeling;Motor;motor disorder;Multiple Birth Offspring;neonate;neural;neurodevelopment;Neurodevelopmental Deficit;neurogenesis;Neuropathogenesis;neuropathology;Outcome;Pathogenesis;Pathway interactions;Phenotype;Pregnant Women;prenatal;prenatal exposure;Primates;Research;Retina;Risk;Sensory;Structure;Symptoms;Testing;Time;unborn child;United States National Institutes of Health;viral transmission;Vision;Visual;Wisconsin;Zika Virus;ZIKV exposure;ZIKV infection

PROJECT_TITLE: Early neural predictors and neuropathogenesis of sensorimotor neurodevelopmental deficits in macaque infants exposed to Zika virus in utero

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative Down Syndrome (DS) is the most common chromosomal disorder with intellectual disability and DS patients acquire neuropathological hallmarks of Alzheimer’s Disease (AD), with a lifetime risk of >80% for developing clinical dementia (DS-AD). The existence of an aging DS population, along with an accelerated age of onset compared to the more general AD population, represents a significant public health concern and a dire need for research focused on the molecular mechanisms that contribute to DS-AD. A growing accumulation of studies highlight astrocyte-secreted proteins as key molecular modulators of characteristic phenotypes in DS and in AD, and this proposal will take both an unbiased approach to characterize astrocyte-specific secretome changes in DS-AD and AD as well as a targeted approach to investigate the potential of one protein candidate, Pleiotrophin, to ameliorate disease progression in DS-AD and AD mouse models.

PI_NAMEs: BRANDEBURA, ASHLEY N (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: abeta accumulation;Address;Adult;Affect;Age;age acceleration;Age of Onset;Aging;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Astrocytes;astrogliosis;Autopsy;Behavioral;Biological;Biology;Biotin;Brain;California;career;cell type;Cells;Characteristics;Chromosome 21;Clinical;comparison control;Compensation;conditioned fear;Congenital chromosomal disease;Data;Data Set;Databases;Dementia;Dendrites;Dendritic Spines;density;Deposition;differential expression;Disease;Disease Progression;Down's Syndrome;Endoplasmic Reticulum;Event;experimental study;Foundations;Future;Gene Dosage;Gene Proteins;Genetic;Genetic Transcription;Growth;hippocampal pyramidal neuron;Hippocampus;Human;Impaired cognition;In Vitro;in vivo;Individual;Intellectual functioning disability;interest;Investigation;knock-down;Knockout Mice;Label;Laboratories;Length;lifetime risk;Link;Literature;Live Birth;Location;Mass Spectrum Analysis;Mediating;Memory impairment;Mentors;Messenger RNA;Mining;Molecular;mouse model;mouse Ts65Dn;mRNA Expression;Mus;Mutation;Neonatal;Nerve Degeneration;Neurodevelopmental Disorder;Neurologist;neuropathology;novel;overexpression;Pathogenesis;Pathologic;Pathology;Patients;Peptide Fragments;Phenocopy;Phenotype;pleiotrophin;Population;Protein Databases;Protein Secretion;Proteins;Proteomics;Public Health;Reporting;Research;Research Personnel;Role;Senile Plaques;Series;single nucleus RNA-sequencing;spatial memory;Stains;Streptavidin;Synapses;Synapsins;System;Technology;Testing;therapeutic target;Tissues;Training;Transcript;Trisomy;Universities;Vertebral column;Viral;Virus;Work

PROJECT_TITLE: Astrocyte-secreted proteins as modulators of neurodegeneration in Down Syndrome and Alzheimers Disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ORG_CITY: STILLWATER

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: The tandem threat of aging and obesity is rising in the U.S., resulting in a disease termed “sarcopenic obesity”, in which the aged experience synergistic muscle loss with both pathologies in combination with increases in body mass and adiposity. Combating the obesity epidemic and encouraging healthy aging is a top priority for the NIH/NIA and they recommend that doctors work closely with obese patients to encourage lifestyle changes, specifically exercise (more muscle mass), while simultaneously treating obese-induced pathologies (glycemic control and high blood pressure). This application seeks to understand the role of muscle mass and its influence on blood pressure regulation and will identify specific pathways and mechanisms induced by increased muscle mass to therapeutically treat obesity-induced hypertension and it’s many other complications.

PI_NAMEs: BUTCHER, JOSHUA THOMAS (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: absorption;Acceleration;Adult;Age;Age Months;aged;Aging;aging population;aging related;Amino Acids;Animal Model;Biology;Blood;blood glucose regulation;blood lipid;Blood Pressure;Blood Pressure Monitors;blood pressure regulation;Blood Vessels;burden of illness;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;Child;Clinic;Conscious;cytokine;Data;db/db mouse;Development;Disease;Dual-Energy X-Ray Absorptiometry;effective intervention;Elderly;Endothelium;Enterobacteria phage P1 Cre recombinase;Enzymes;Epidemic;Equilibrium;Evaluation;Exercise;exercise intervention;experience;Fiber;fitness;Functional disorder;GDF8 gene;Genes;Glucose;Glucose tolerance test;glycemic control;Goals;Growth;Hand;Health;healthy aging;human model;Hypertension;impaired glucose tolerance;improved;improved outcome;in vivo;indexing;Injury to Kidney;Intervention;juvenile animal;Kidney;Knock-out;Life Style;Link;Literature;Locomotion;Medical;Metabolic;Metabolic dysfunction;Methods;Modeling;mouse model;Mus;Muscle;muscle aging;Muscle Fibers;muscle form;Muscle function;Muscle Proteins;muscle strength;Muscular Atrophy;Myography;NADPH Oxidase 1;novel;Obese Mice;obese patients;Obesity;Obesity Epidemic;obesity treatment;Organ;Outcome;overexpression;oxidant stress;Oxidants;Pathology;Pathway interactions;patient population;Phenotype;Play;Population;pressure;Prevalence;prevent;Prevention;Production;programs;protein degradation;Recommendation;Renal function;Renal Hypertension;Research;Risk Factors;Role;sarcopenia;sarcopenic obesity;Skeletal Muscle;skeletal muscle growth;Stream;Superoxides;Telemetry;Testing;Therapeutic;Thinness;Tissues;Training;Transgenic Organisms;Translating;United States National Institutes of Health;Vascular Diseases;Work

PROJECT_TITLE: Skeletal Muscle as a Target for Cardio-Metabolic Disease in Sarcopenic Obesity

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Biological Aging Study Section[NIA-B]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Physical Activity;Prevention;Rehabilitation;Telehealth;Urologic Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because a significant proportion of men will experience lower urinary tract symptoms attributed to benign prostatic hyperplasia in their lifetime, but existing treatments have limited efficacy and important risks. Exercise is a promising intervention that targets novel frailty-related mechanisms of bothersome urinary symptoms in physically inactive older men. Thus, the proposed research is relevant to the NIDDK’s scientific goal to advance pivotal clinical studies and trials to improve the health and quality of life for people with urologic diseases.

PI_NAMEs: BAUER, SCOTT RYAN (contact);KENFIELD, STACEY

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: actigraphy;Address;Adherence;adherence rate;Adrenergic alpha-Antagonists;Aerobic Exercise;Affect;Aging;aging related;alpha-1-microglobulin;American;arm;Behavioral;Benign Prostatic Hypertrophy;Biofeedback;Biological Markers;Body System;Cardiovascular Diseases;Cessation of life;Clinical;clinical care;Clinical Research;Clinical Trials;Diabetes Mellitus;disability;Disease;efficacy trial;Enrollment;Equipment;Erectile dysfunction;Exercise;exercise intervention;exercise prescription;exercise program;Exercise Test;experience;falls;Feedback;Foundations;Fracture;frailty;Functional disorder;Future;Goals;Health;Health education;heart rate monitor;Home;Impairment;improved;innovation;Instruction;International;Intervention;Interview;Laboratories;lower urinary tract symptoms;male;Malignant neoplasm of prostate;Measurement;Measures;men;Mission;Mitochondria;mitochondrial dysfunction;Mobility decline;muscle form;National Institute of Diabetes and Digestive and Kidney Diseases;novel;older men;Operative Surgical Procedures;Outcome;Participant;Performance;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Physical activity;Physical Function;physical inactivity;Physiological;Pilot Projects;pilot trial;prevent;primary outcome;programs;Prostate;Protocols documentation;Public Health;Publishing;Quality of life;Randomized, Controlled Trials;remote monitoring;Research;resistance exercise;response;retention rate;Risk;Safety;safety outcomes;sample collection;secondary outcome;Severities;side effect;Structure;Symptoms;telephone coaching;Testing;Theory of Change;therapy design;treatment arm;trial design;urinary;Urine;urologic;Urologic Diseases;video chat;Walking;Work;Writing

PROJECT_TITLE: Prescription exercise for Older men with Urinary Disease (PROUD) pilot study

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ROCHESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Narrative The overall goal of this project is to determine whether the Human Herpesvirus 6A (HHV6A) latency gene U94A plays a role in Alzheimer’s disease. The study is motivated by recent multiscale network analyses of Alzheimer patients that revealed specific and significant association of Alzheimer disease (AD) with HHV6A. We use Alzheimer patient derived cells and a new mouse model to test the overall hypothesis that U94A, which is expressed during latent HHV6A infection, is a disease-modifying factor that impairs the normal function of neurons and glial cells, and may increase patient vulnerability to other AD causing factors thereby accelerating AD onset and pathology.

PI_NAMEs: MAYER-PROSCHEL, MARGOT  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: abeta accumulation;Acceleration;Address;Affect;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Animal Model;APP-PS1;Axon;Behavioral Assay;benign state;Brain;Cell Culture System;Cell Physiology;Cells;cellular pathology;cellular transduction;Central Nervous System;Cognitive deficits;cohort;Cytoskeleton;Data;Defect;Demyelinations;Dendritic Spines;Development;Diffuse;Disease;Disease Progression;Environmental Risk Factor;epidemiology study;experimental study;familial Alzheimer disease;Gelsolin;Genes;Genetic;Goals;HHV-6A;Human;Human Herpesvirus 6;hyperphosphorylated tau;Impaired cognition;Impairment;In Vitro;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Infection;Infectious Agent;Inflammation;insight;Knock-in Mouse;Learning;Length;Light;Link;Memory;Microscopy;Microtubules;migration;Morphology;mouse model;multiple omics;Mus;mutant;Mutation;Neurites;Neurodegenerative Disorders;Neuroglia;Neurons;neurotropic virus;oligodendrocyte progenitor;Oligodendroglia;Onset of illness;Pathogenicity;Pathologic;Pathology;Pathway Analysis;Pathway interactions;patient derived induced pluripotent stem cells;Patients;performance tests;Phenotype;Process;Proteins;Proteomics;Publishing;Regulation;remyelination;Resolution;Risk Factors;Role;Severities;sex;stem cells;Swedish mutation;Synapses;System;tau-1;Testing;tool;transcriptomics;Transgenic Mice;Variant;vector control;Virus Diseases;Virus Latency;Visualization;Work

PROJECT_TITLE: Impact of the Human Herpesvirus 6A (HHV6A) latency gene U94A on Alzheimer disease pathology


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PI_NAMEs: BURNER, ELIZABETH RHEA ERWIN (contact);SIEGEL, STEVEN J

PROGRAM_OFFICER_NAME: BROWN, PATRICK

PROJECT_TERMS: 18 year old;Address;Adult;Archives;Belief;burden of illness;California;career;career development;certificate program;Clinical;clinical translation;Communication;community engagement;Community Health;Crime;Data;Data Science;design;Development Plans;digital;Distance Education;Ecosystem;Education;Educational Materials;empowerment;Enrollment;Evaluation;Faculty;federal poverty level;Funding;Health;health care delivery;health data;health disparity;Heart;high school;improved;Individual;Institution;Knowledge;Language;Leadership;Link;Los Angeles;mentoring community;Mentors;Minority Groups;novel;oral communication;Pediatric Hospitals;Population Heterogeneity;Poverty;precision medicine;Process;Productivity;Program Development;programs;recruit;Reproducibility;Research;Research Methodology;resilience;Resources;Science;Series;skills;success;tool;Training;training opportunity;translational barrier;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities;visiting scholar;working group

PROJECT_TITLE: Institutional Career Development Core


NIH_SPENDING_CATS: Genetics

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Accurate cell growth and division is important for the development and survival of all organisms. When the controls on cell division are lost, this can lead to uncontrolled cellular proliferation and cancer. The goal of this project is to investigate the pathways that regulate cell division, which will provide insight into how they protect against the development of cancer.

PI_NAMEs: BENANTI, JENNIFER A (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Alleles;biological adaptation to stress;Cell Cycle;Cell Cycle Arrest;Cell Cycle Proteins;Cell Cycle Regulation;Cell division;cell growth;Cell Proliferation;Cells;Deubiquitinating Enzyme;Development;Disease;Ensure;environmental stressor;enzyme substrate;Enzymes;event cycle;Genetic;genetic approach;Genetic Transcription;Goals;Growth;Human;in vivo;insight;Laboratories;Malignant Neoplasms;Mediating;Molecular;Mutation;Organism;Pathway interactions;Phosphorylation;Production;Proliferating;protein degradation;Proteolysis;Regulator Genes;response;Saccharomycetales;Stress;System;Testing;transcription factor;Ubiquitin;ubiquitin isopeptidase;Work;Yeasts

PROJECT_TITLE: Molecular Mechanisms of Cell Cycle Control

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Rare genetic diseases are estimated to affect the lives of 25 to 30 million Americans and their families, and present a significant economic burden on the healthcare system. Currently, our knowledge of the broad spectrum of the 7,000 observed rare diseases is limited to a few well-studied ones, hindering our ability to make correct and timely diagnoses. The objective of this study is to improve the identification of patients with rare diseases in healthcare systems by developing data science approaches that automatically recognize rare disease-related patterns in patient health records and correlate them with genomic data, thus, aiding in diagnosis and discovery.

PI_NAMEs: PEJAVER, VIKAS RAO (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Acceleration;accurate diagnosis;Adult;Affect;American;Award;Basic Science;Behavioral;Bioinformatics;biomedical data science;biomedical informatics;career;causal variant;Clinical;Clinical Data;clinical data warehouse;clinical decision-making;Clinical Research;cohort;Computing Methodologies;Consensus;Data;Data Science;Data Set;Detection;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostics Research;Disease;disease phenotype;early onset disorder;Economic Burden;Electronic Health Record;Environment;exome sequencing;Faculty;Family;Frequencies;gene discovery;Genes;Genetic;genomic data;Genomics;Genotype;Goals;health care delivery;health data;health record;Healthcare;Healthcare Systems;improved;Individual;Informatics;Knowledge;Machine Learning;Manuscripts;Markov Chains;Medical;Medical Genetics;Medicine;member;Mental disorders;Mentors;Mentorship;Methods;Mining;Modeling;Molecular;multimodal data;Names;Natural Language Processing;Natural Language Processing pipeline;novel;Ontology;open source;Outcome;Pacific Northwest;patient health information;Patient Recruitments;Patients;Pattern;Persons;Phase;Phenotype;phenotypic data;Population;Positioning Attribute;Prevalence;Principal Investigator;prototype;psychologic;rare condition;Rare Diseases;rare genetic disorder;Recording of previous events;recruit;Research;Research Personnel;skills;software development;Standardization;support tools;Symptoms;System;Testing;tool;Training;trait;Universities;Validation;Visualization;Vocabulary;Washington;Work

PROJECT_TITLE: Integrative data science approaches for rare disease discovery in health records


ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative A pressing societal need is to ensure that the vast number of aging adults can maintain their independence and a good quality of life. Successful use of technology systems is critical to everyday functioning. Thus, examining issues surrounding aging and technology is important to the well-being and independence of older adults.

PI_NAMEs: CZAJA, SARA J (contact)

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: Achievement;Address;Adult;Age;age related changes;Age-associated memory impairment;Aging;aging and technology;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Artificial Intelligence;Awareness;Businesses;Cellular Phone;Chronic;Clinical;Cognition;Cognitive;cognitive enhancement;cohort;Communities;community advisory board;Data;design;Development;Education;Emerging Technologies;Emotional;Enhancement Technology;ethnic diversity;ethnic minority;Ethnic Origin;evidence base;faculty support;Family;Florida;Fostering;Goals;Health;health care disparity;health management;Health Services Accessibility;Healthcare;Heterogeneity;human old age (65+);Illinois;Impaired cognition;improved;Industry;industry partner;innovation;Institution;Internet;Intervention;Learning;Literature;Location;Loneliness;low socioeconomic status;Marketing;Medicine;meetings;Mentors;mild cognitive impairment;minority disparity;Mission;multidisciplinary;older adult;Personal Satisfaction;physical conditioning;Play;Policies;Population;Population Heterogeneity;prevent;Productivity;programs;Protocols documentation;Quality of life;racial diversity;Research;Research Personnel;Resources;response;Risk Factors;Rural;rural area;Safety;Sampling;Scientist;sex;Shapes;Site;social engagement;Social isolation;Solid;Strategic vision;Students;Subgroup;System;Target Populations;Technical Expertise;Techniques;Technology;technology platform;tool;Training;trend;United States National Institutes of Health;uptake;usability;Vision

PROJECT_TITLE: Center for Research and Education on Aging and Technology Enhancement - CREATE


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Patient Safety;Rural Health;Social Determinants of Health

PROJECT_TERMS: Adopted;Adult;Age;Aging;aging and technology;Alzheimer's Disease;Alzheimer's disease related dementia;Annual Reports;Area;Artificial Intelligence;Clinical;Clinical Trials Data Monitoring Committees;Cognition;Cognitive;cohesion;cohort;Collaborations;Communities;community advisory board;community organizations;Community Services;Data;Data Collection;design;Development;disability;Education;Educational Status;Emerging Technologies;Enhancement Technology;Ensure;Environment;Evaluation;Faculty;Feedback;Florida;Fostering;Foundations;Funding;Goals;Government;Government Agencies;Guidelines;Health;health management;Illinois;Impaired cognition;Industry;innovation;Institution;intelligent personal assistant;International;knowledge base;Leadership;Manuscripts;Measures;Medicine;member;mild cognitive impairment;Minority;multidisciplinary;new technology;older adult;organizational structure;Outcome;Patient Recruitments;Peer Review;Persons;Play;Policies;Policy Maker;Population Heterogeneity;Productivity;Professional Organizations;programs;Protocols documentation;Public Policy;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;retention rate;Risk Factors;rural area;Safety;Sampling;Science;Scientist;Site;social engagement;socioeconomics;Structure;Students;success;System;Technology;technology development;technology platform;tool;Training;Training Programs;Translating;trend;United States National Institutes of Health;Universities;uptake;usability;virtual reality;Work;working group

PROJECT_TITLE: Administration Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative Hyperphosphorylated tau accumulation in the locus coeruleus (LC), the sole source of noradrenergic innervation in hippocampus, is the earlies insult in Alzheimer’s disease (AD), and loss of hippocampal noradrenergic innervation underlies cognitive deficits AD patients. We will use the novel TgF344-AD rat model to discover how LC damage alters hippocampal circuit function in a sex dependent way, and determine whether increasing the post-translational modification O-GlcNAcylation protects the LC system during disease progression.

PI_NAMEs: MCMAHON, LORI LYNN (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: AD transgenic mice;Adrenergic Agents;Adrenergic Antagonists;Adrenergic Receptor;Aging;Agitation;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Anxiety;APP-PS1;Attention;Axon;axonal degeneration;Back;basal forebrain;Behavior;beta-2 Adrenergic Receptors;beta-adrenergic receptor;Biochemistry;Biology;Brain;Brain region;Cell Nucleus;Cells;Chemicals;Chemosensitization;cholinergic;Clinical;Cognition;Cognitive deficits;cognitive performance;comorbid depression;comorbidity;Control Locus;Data;Denervation;density;dentate gyrus;Disease;Disease Progression;Distal;Electrophysiology (science);emerging adult;Estradiol;experience;Female;Fiber;Fright;Functional disorder;Genetic;granule cell;Hippocampal Formation;Hippocampus;Human;human disease;hyperphosphorylated tau;Impairment;improved;innovation;Intervention;Knowledge;Learning;Lesion;Link;Literature;locus ceruleus structure;Mainstreaming;male;Masks;Medial;Memory;Memory impairment;Menopause;Mental Depression;Mental Health;Modeling;mouse model;Mus;Mutation;neglect;nerve supply;neuroinflammation;neuron loss;Neuronal Dysfunction;neuronal excitability;Neurons;noradrenergic;Norepinephrine;novel;Outcome;Ovarian hormone;Ovariectomy;Pathologic;Pathology;Patients;Perforant Pathway;pharmacologic;Pharmacology;Phosphorylation;Plasma;Positioning Attribute;Post-Translational Protein Processing;pre-clinical;preservation;prevent;prodromal Alzheimer's disease;Proestrus;Prosencephalon;Rattus;receptor function;Reporting;Research;Role;Serine;sex;Sex Differences;sexual dimorphism;Slice;Source;spatial memory;Synapses;synaptic function;Synaptic Transmission;System;tau aggregation;tau Proteins;tau-1;Testing;Therapeutic;Therapeutic Intervention;Threonine;Transgenic Mice;Up-Regulation;Woman;Work

PROJECT_TITLE: Consequences of Noradrenergic Degeneration in the Novel TgF344-AD Rat Model

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Glioblastomas are a common form of brain tumor in both adults and children and DNA damaging treatments (radiation and chemotherapy) are still the most effective agents in this disease. We have identified features of glioblastomas that seem to predispose them to uncontrolled growth and this proposal will evaluate how those features could be leveraged as targets for new drugs, especially CHK1/2 inhibitors, to improve existing treatments for this disease by combination therapies.

PI_NAMEs: BEROUKHIM, RAMEEN  (contact);LIGON, KEITH LLOYD

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Adult;Alkylating Agents;Bar Codes;Biological Markers;Brain Neoplasms;cancer cell;cancer type;CDKN2A gene;Cell Cycle;Cell Cycle Regulation;Cell Differentiation process;Cells;checkpoint inhibition;CHEK1 gene;CHEK2 gene;chemotherapy;Chemotherapy and/or radiation;Child;Clinical Trials;Clinical Trials Design;Clonal Evolution;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Development;Diagnostic;Disease;DNA Damage;Epigenetic Process;gene discovery;Genes;genome-wide;Genomics;Genotoxic Stress;genotoxicity;Glioblastoma;Glioma;glioma cell line;Growth;Heterogeneity;Immune checkpoint inhibitor;improved;improved outcome;Induction of Apoptosis;inhibitor;innovation;Lomustine;Malignant Neoplasms;MDM2 gene;Mediating;Mediator;Mesenchymal;Methods;Mitotic;Neurosphere;new therapeutic target;Normal Cell;novel;Null Lymphocytes;Optics;Outcome;Pathway interactions;patient subsets;Patients;Pharmaceutical Preparations;Population;Radiation;RB1 gene;replication stress;Research;Resistance;resistance mechanism;response;response biomarker;Sampling;single-cell RNA sequencing;small molecule;Stress;synthetic lethal interaction;targeted treatment;temozolomide;Testing;Therapeutic;therapy resistant;Toxic effect;TP53 gene;transcription factor

PROJECT_TITLE: Synthetic lethalities to cell cycle disruption in glioma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]