NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Mental Health;Social Determinants of Health

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE A growing number of Americans report experiencing chronic loneliness, which is not only itself distressing but confers increased risk for mental and physical health problems (e.g., depression; heart disease), cognitive decline, and all-cause mortality. Despite efforts to address this pressing public health issue, rates of loneliness continue to increase, and progress has stymied, due in part to a lack of collaboration across disciplines and methods that cannot fully capture the complex interactions among biopsychosocial contributors to loneliness. The proposed study uses computational modeling to formalize an interdisciplinary theory of loneliness, rigorously test the hypotheses put forth by this theory using simulated data, and identify knowledge gaps that will serve as critical targets of future study to improve our understanding and treatment of chronic loneliness.

PI_NAMEs: TONER, EMMA ROSE (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Address;Adult;Affective;American;Anxiety;Anxiety Disorders;Automobile Driving;Behavior;Behavioral;Belief;biopsychosocial;career;Chronic;Clinical;Clinical Psychology;Clinical Sciences;Cognition;Cognitive;Cognitive Science;Collaborations;Complex;computer code;Computer Models;Data;Dedications;Development;Differential Equation;Discipline;Distress;Educational workshop;effective intervention;Exhibits;experience;Feeling;Friends;Future;hands-on learning;Health;Heart Diseases;Impaired cognition;improved;Individual;insight;interdisciplinary collaboration;Intervention;Knowledge;Language;Literature;Loneliness;lonely individuals;Maintenance;mathematical model;Mathematics;Mental Depression;Mental disorders;Mental Health;Mentorship;Methodology;Methods;Modeling;models and simulation;mortality;National Institute of Mental Health;Nature;novel;Outcome;Pathway interactions;Persons;physical conditioning;Policies;Population;Prevention;Process;psychologic;Psychological Theory;Psychopathology;psychosocial;Public Health;Reporting;Research;Research Personnel;Risk;Risk Reduction;Science;Scientist;simulation;social;Social Interaction;Social isolation;Social Network;Social Psychology;social relationships;Sociology;Strategic Planning;Structure;Surveys;System;systematic review;Testing;theories;Thinking;Time;tool;Training;verbal;Work;Writing

PROJECT_TITLE: Using computational modeling to formalize an integrated psychosocial theory of loneliness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE & PUBLIC HEALTH RELEVANCE Chronic stress contributes to many neuropsychiatric disorders, leads to cellular adaptations in the brain, and it can influence other organs throughout the body via the release of stress hormones and norepinephrine. This proposal aims to elucidate how norepinephrine signaling in microglia remodels neuron activity in response to chronic and acute stress using a combination of molecular, imaging, and behavioral approaches. As such, the results of this work will shed light on microglia-neuron interactions during stress and could reveal new strategies to develop novel therapeutics for stress-related disorders such as anxiety, depression, or post-traumatic stress disorder.

PI_NAMEs: CORONA, ALBERTO  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Ablation;Action Potentials;acute stress;Adult;Animals;antagonist;Anxiety;Attenuated;Aversive Stimulus;Award;Behavior;Behavioral;beta-2 Adrenergic Receptors;Biological Sciences;Brain;Breeding;Calcium Signaling;career development;cell type;Cells;Chronic;Chronic stress;Closure by clamp;Cognition;Cognitive;Cognitive deficits;conditional knockout;conditioned fear;Consumption;Data;Development Plans;Educational process of instructing;Emotional;Exhibits;experimental study;Exposure to;Fiber;fluorescence imaging;Frequencies;Gene Expression Profile;Genes;Genetic Transcription;Habenula;Hormones;Image;Implant;In Situ Hybridization;in vivo;in vivo imaging;Inflammatory;innovation;insight;Lateral;Learning;lens;Lesion;Macrophage Colony-Stimulating Factor Receptor;Major Depressive Disorder;Mediating;Mental Depression;Mentors;Microglia;Modeling;Molecular;Monitor;Mus;Neurons;neuropsychiatric disorder;Norepinephrine;novel therapeutics;Organ;Pathway interactions;Phase;Photometry;Physiological;Play;Positioning Attribute;Post-Traumatic Stress Disorders;Procedures;programs;public health relevance;Research;Resolution;response;restraint stress;reward processing;Rewards;Risk Factors;Role;sensor;Signal Transduction;single-cell RNA sequencing;Site;Slice;Slide;Stress;stress related disorder;stressor;Tamoxifen;Testing;Training;transcriptomics;Whole-Cell Recordings;Wild Type Mouse;With laterality;Work

PROJECT_TITLE: Norepinephrine-sensing habenular microglia and stress-related behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE This work aims to enhance craniofacial reconstruction by developing a nuanced understanding of the mechanisms underlying bone regeneration, focusing on the influence of the microenvironment in this process. By engineering a series of biomimicking hydrogels that replicate the stages of bone formation, this project seeks to evaluate the role of the microenvironment, by varying matrix density and mineralization, on stem cell differentiation and bone regeneration, aiming to find factors conducive to faster healing to overcome the limitations of current bone grafting methods. The potential to accelerate bone regeneration presents profound public health implications, including decreasing the dependency on limited donor grafts, eliminating donor-site morbidity, expediting patient recovery, and broadening treatment options for managing bone loss.

PI_NAMEs: VIGNOLO, SOFIA MAGALI (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acceleration;Address;Adhesions;Area;Autologous;Autologous Transplantation;Benchmarking;Binding Sites;Biochemical;Biocompatible Materials;Biological Assay;Biomedical Engineering;Biomimetics;biomineralization;bone;Bone Development;bone healing;bone loss;Bone Regeneration;bone repair;Bone Tissue;Bone Transplantation;calcification;Calvaria;career;cell behavior;Cell Communication;Cell Differentiation process;Cell Physiology;cell regeneration;cell type;Cells;Clinical;Collagen;Communication;comparative;Complex;craniofacial;craniofacial bone;craniofacial development;cranium;Data;Defect;density;Dependence;design;Development;Differentiation Antigens;differentiation in vitro;early onset;Educational process of instructing;Engineering;Environment;Extracellular Matrix;Face;Failure;Fellowship;Focal Adhesions;Future;Gel;Genes;Genomics;Goals;healing;Human;hydrogel scaffold;Hydrogels;Immature Bone;Immune response;improved;In Vitro;in vivo;Incidence;Injectable;innovation;insight;Institution;intramembranous bone formation;Knowledge;Leadership;Link;mechanical properties;mechanical signal;mechanical stimulus;mechanotransduction;Mesenchymal;Mesenchymal Stem Cells;Methods;mineralization;minimally invasive;Modeling;Molecular;molecular dynamics;Morbidity - disease rate;nano-string;nanoscale;Natural regeneration;next generation;Operative Surgical Procedures;Osteogenesis;osteogenic;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Perception;Physical condensation;Physiologic Ossification;Process;Proteins;Public Health;Rattus;reconstruction;Recovery;recruit;regeneration potential;regenerative approach;Regenerative capacity;Regenerative response;regenerative therapy;regenerative tissue;repair strategy;response;Role;scaffold;Scientist;sensor;Series;Signal Transduction;Site;skills;stem;stem cell biology;stem cell differentiation;stem cell model;stem cells;Stromal Cells;Surgeon;Testing;Tissue constructs;Tissue Donors;Tissue Engineering;Training;transcriptomics;Translating;Undifferentiated;Vascularization;Work

PROJECT_TITLE: Bioengineering the bone microenvironment for improved craniofacial regeneration leveraging biomimetic mechanotransduction

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 JC (18)]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Craniofacial anomalies make up around one-third of all birth defects, and cleft palate occurs in greater than one out of every 1500 live births. During secondary palate morphogenesis, complex cell movement within the heterogeneous palatal mesenchyme is essential, but how this movement is regulated remains unclear. This proposal aims to address this gap using state-of-the-art approaches and new tools for studying cellular movement during morphogenesis in mammalian craniofacial development with the ultimate goal of advancing therapeutic treatments.

PI_NAMEs: SHAMARDANI, KARIN  (contact)

PROJECT_TERMS: Actin-Binding Protein;Actomyosin;Address;Adhesions;Affect;Behavior;Binding;Biochemical Pathway;biophysical properties;cell behavior;Cell Culture Techniques;cell motility;Cell Proliferation;Cell Separation;Cells;cleft lip and palate;Cleft lip with or without cleft palate;Cleft Palate;Collaborations;Complex;Congenital Abnormality;congenital anomaly;craniofacial;Craniofacial Abnormalities;craniofacial development;craniofrontonasal syndrome;Craniosynostosis;Cytoskeleton;Data;Development;Disease;Dysmorphology;Embryo;Ephrin B Receptor;Epithelium;Etiology;Exhibits;F-Actin;Failure;Female;Frontonasal dysplasia;gene function;Generations;Genes;Genetic;Goals;Heterozygote;Image Analysis;imaging modality;improved;in vivo;Incidence;Individual;intercellular communication;Laser Scanning Confocal Microscopy;Length;Link;Live Birth;loss of function;loss of function mutation;male;Measures;Mediating;Mesenchymal;Mesenchyme;Methods;Molecular;Morphogenesis;Mosaicism;mouse genetics;mouse model;Movement;Mus;Mutation;Nature;Orbital separation excessive;palatal shelves;Palate;Pathway interactions;Phenotype;physical property;polarized cell;Positioning Attribute;Process;Proliferating;Protein Family;Proteins;quantitative imaging;Regulation;Research;Role;Secondary Palate;Secondary to;Shapes;Signaling Protein;skeletal;Structure;Testing;Therapeutic;Three-Dimensional Imaging;Tissues;tool;Universities;Work;X Inactivation

PROJECT_TITLE: Cellular mechanisms of palatal shelf outgrowth


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: KNOXVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: PROJECT NARRATIVE Membrane proteins are fundamental for the function of the cell. When membrane proteins malfunction, diseases such as cancer occur. We propose to develop a method that allows to study how membrane proteins work, and to design molecules that can be used to prevent errors in the activity of membrane protein.

PI_NAMEs: BARRERA, FRANCISCO NICOLAS (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Acidity;Autoimmune Diseases;Binding;Cell Physiology;Data;design;Development;Disease;Generations;improved;Investigation;Knowledge;Ligand Binding;Ligands;Lipids;Malignant Neoplasms;Membrane;membrane activity;Membrane Proteins;Methods;Molecular;novel therapeutic intervention;Peptides;prevent;receptor;receptor function;single molecule;Stimulus;Thermodynamics;Tissues;Transmembrane Domain;Work

PROJECT_TITLE: Mechanisms of modulation of transmembrane interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: FD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: LEXINGTON

ORG_NAME: CANNABIS REGULATORS ASSOCIATION

ORG_STATE: KY

PHR: PROJECT NARRATIVE Laws legalizing cannabis use for adults have increased exponentially across the U.S. since 2010 with 38 states, the District of Columbia (D.C.), and four U.S. territories legalizing cannabis for medicinal use and 24 of those states, D.C., and three U.S. territories also legalizing cannabis for non-medical (recreational) use. Policy change has outpaced scientific research, and in the absence of federal legalization of cannabis, states have taken different policy approaches, providing a natural experiment that can lend insight into how policies impact consumer safety, public health, and equity. The Cannabis Regulators Association is a nonpartisan association of government agencies regulating cannabis and/or hemp. CANNRA’s 2024 Annual Member Meeting brings together over 200 agency officials and their staff to share emerging practices and develop skills to advance regulatory science.

PI_NAMEs: SCHAUER, GILLIAN L (contact)

PROGRAM_OFFICER_NAME: HEAD, DANIELLE

PROJECT_TITLE: Cannabis Regulators Association 2024 Annual Member Meeting: Furthering Regulatory Exchange and Collaboration

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 ORA-T (06)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: LIEBER INSTITUTE, INC.

ORG_STATE: MD

PHR: Project Narrative  Social recognition, or the ability to distinguish between familiar and novel conspecifics, is essential for organismal survival as organisms must be able to direct their behavior based on social stimuli. This proposal seeks to elucidate the functional role of basolateral amygdala-activated, lateral septum ensembles in social recognition and to comprehensively characterize their molecular signature. Elucidating the neural substrates that regulate social recognition is essential to understanding how social experience shapes the brain.

PI_NAMEs: PHILLIPS, ROBERT  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Amygdaloid structure;Attenuated;basal forebrain;Behavior;Behavioral;brain control;brain shape;Calcium;cell type;Cells;Code;Cues;Data;designer receptors exclusively activated by designer drugs;Diphtheria Toxin;Discrimination;Enterobacteria phage P1 Cre recombinase;Etiology;experience;experimental study;Exposure to;Genetic;Genetic Transcription;Genomics;Goals;Heterogeneity;Human;Image;Immediate-Early Genes;in vivo;innovation;Lateral;Lesion;Light;Maps;Mediating;Molecular;Molecular Profiling;mRNA Expression;Mus;neural;Neurobiology;Neurodevelopmental Disorder;Neurons;new therapeutic target;novel;optogenetics;Organism;Population;Publishing;recruit;Reporting;Research;response;Role;Series;single nucleus RNA-sequencing;social;Social Behavior;social deficits;Social Development;Social Interaction;Stimulus;Structure;Testing;Tissues;tool;transcriptomics;Translations

PROJECT_TITLE: Identifying a functional role for transcriptionally distinct, BLA-activated LS ensembles in social behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (06)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Lipids regulate the activity of a variety of mechanically gated ion channels, including those found in cochlear hair cells. Here, I propose to determine the molecular mechanism by which PIP2 affects mechanotransduction in cochlear hair cells. Based on published and preliminary data, I anticipate that PIP2 affects MET at least in part by direct interactions with components of the MET channel in cochlear hair cells.

PI_NAMEs: MITTELSTADT, JONAH KENDAHL (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Affect;alpha helix;Amino Acids;Apical;auditory pathway;Binding;Binding Sites;Biochemistry;Calcium and Integrin Binding Protein 2;Cell membrane;Cells;Charge;Cochlea;Complex;CRISPR/Cas technology;Cytoplasmic Tail;Data;Disease;Electrophysiology (science);Elements;Engineering;Environment;experimental study;extracellular;Filament;Gene Transfer;Genes;Hair Cells;Hearing;hearing impairment;Human;in vivo;Inner Hair Cells;insight;Ion Channel;Ion Channel Gating;Left;Link;Lipids;Maps;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Modeling;Molecular;mouse genome;Mus;Mutation;pharmacologic;Phosphatidylinositol 4,5-Diphosphate;Phospholipids;Physiological;Piezo 1 ion channel;Point Mutation;Probability;Process;Property;Proteins;Publishing;Regulation;Reporting;Rest;Sensory;Sensory impairment;Signal Transduction;Site;sound;Surface;Tertiary Protein Structure;Testing

PROJECT_TITLE: Regulation of hair cell mechanotransduction by PIP2

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (15)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Due to the development of highly effective treatments for HIV and the resulting increased longevity among people with HIV, this population now loses more life years to smoking than to HIV infection itself. Novel and effective models to deliver wider reaching smoking cessation interventions to individuals with HIV are highly needed and indicated as a priority for NIH. This study will generate new clinical evidence for a novel intervention for this population as well as guidance about how to implement it in real-world settings.

PI_NAMEs: ASHARE, REBECCA ;MCCLERNON, FRANCIS JOSEPH;VILARDAGA, ROGER  (contact)

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: Abstinence;Address;Adherence;African American;Anti-Retroviral Agents;Area;arm;Behavioral;Biochemical;Cancer Control;cancer diagnosis;cancer health disparity;Cigarette;Clinic;Clinical;Clinical effectiveness;Clinical Practice Guideline;Cognitive deficits;Communities;community advisory board;compare effectiveness;Confidence Intervals;Consolidated Framework for Implementation Research;Control Groups;cost;craving;Data;design;Development;digital applications;digital intervention;digital treatment;Disease;effective therapy;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Electronic cigarette;evidence base;experience;Future;General Population;Guidelines;Health;health equity;Health Personnel;HIV;HIV Infections;Hybrids;implementation evaluation;implementation facilitators;implementation science;implementation strategy;Improve Access;Individual;interest;Intervention;Interview;Learning;Life;Longevity;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mental Health;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;National Cancer Institute;nicotine replacement;novel;Outcome;Patient Self-Report;Patients;Persons;Phase;Pilot Projects;pilot trial;Play;Population;Population Intervention;Prevalence;prevent;primary outcome;Public Health;Quality of life;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Research Design;Research Priority;research to practice;Sampling;secondary outcome;Secure;Services;Smoke;Smoking;smoking cessation;Smoking Cessation Intervention;smoking prevalence;smoking-related cancer;social;social stigma;Strategic Planning;Stress;substance use;Surveys;Technology;Testing;therapeutic biomarker;therapy adherence;therapy design;Tobacco use;Tobacco Use Disorder;treatment effect;Uncertainty;United States National Institutes of Health;user centered design;Voice;Work

PROJECT_TITLE: Hybrid Trial of a Tailored Smoking Cessation Digital Therapeutic for Persons Living with HIV


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Head and neck cancer patients experience severe pain and stress. The proposed studies investigate how sympathetic and sensory nerves interact to drive cancer pain. This approach has the potential for new therapeutic strategies to treat cancer pain through adrenergic pharmacology.

PI_NAMEs: MARTEL MATOS, ANDRE ALEXANDER (contact)

PROJECT_TERMS: Adrenergic Agents;Adrenergic Receptor;afferent nerve;Afferent Neurons;Anatomy;Animals;Behavior;beta-adrenergic receptor;Blood;Blood specimen;Calcium;cancer pain;Cancer Patient;carcinogenesis;career;Cells;Clinical;Coupled;Data;density;Descriptor;designer receptors exclusively activated by designer drugs;Development;Diagnosis;emotional experience;Enzyme-Linked Immunosorbent Assay;experience;experimental study;Face;G alpha q Protein;Genetic;genetic technology;Grooming;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;Hypersensitivity;Image;Immunohistochemistry;improved;in vivo;Injury;Knowledge;Link;malignant mouth neoplasm;Malignant Neoplasms;Modeling;Molecular;mouse model;mouth squamous cell carcinoma;Mus;Nerve;nerve injury;nerve supply;neuronal tumor;Neurons;neurotransmission;Nociception;Nociceptors;Norepinephrine;novel therapeutic intervention;oral tumorigenesis;orofacial;Orofacial Pain;Pain;pain behavior;Pain management;pain reduction;painful neuropathy;patient population;Patients;Peripheral;Persistent pain;Pharmacology;pre-clinical;prognostic indicator;Prospective Studies;Quality of life;Questionnaires;receptor;receptor coupling;Receptor Gene;Reporting;Research;Resected;response;Role;Secondary to;Sensory;Sensory Ganglia;sensory neuropathy;Signal Transduction;Signaling Protein;skills;spontaneous pain;Squamous cell carcinoma;Stress;Structure of trigeminal ganglion;Sympathectomy;Sympathetic Nervous System;Testing;Tissue Sample;Tongue;Tongue Neoplasms;Training Programs;tumor;tumor growth;Tumor Tissue;Up-Regulation

PROJECT_TITLE: Sensory-Sympathetic Nerve Interplay in Oral Cancer


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Cancer;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: OVERALL PROJECT NARRATIVE Yale Cancer Center (YCC) is committed to eliminating the burden of cancer through transformative research, with attention to the needs of all people facing this disease. Our goal is to understand and prevent cancer, detect cancer early, and manage cancer more effectively, while maximizing access to care, addressing the needs of the community, ensuring equity and diversity in our workplace, and training future cancer researchers, clinicians, and leaders.

PI_NAMEs: WINER, ERIC P (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Academia;Address;anti-cancer research;Area;Attention;Award;Back;Basic Cancer Research;Basic Science;Biological Markers;Cancer Burden;cancer care;Cancer Center Support Grant;cancer health disparity;cancer prevention;cancer therapy;career development;Caring;Catchment Area;Clinic;Clinical;clinical care;Clinical Sciences;Clinical Trials;Collaborations;combat;Communities;community involvement;Connecticut;design;Diagnosis;Direct Costs;Disease;Disparity;Disparity in diagnosis;disparity reduction;Diverse Workforce;diversity and equity;Dreams;Ensure;Equity;Fostering;Funding;Future;Goals;Grant;Health Services Accessibility;Heart;HIV;Immune System Diseases;Improve Access;improved;Individual;Industry;innovation;Institution;Investments;Journals;Knowledge;Laboratories;Leadership;Link;Malignant neoplasm of lung;Malignant Neoplasms;member;Mentors;NCI Center for Cancer Research;next generation;novel;novel therapeutic intervention;Outcome;Output;Patient Selection;Patients;Peer Review;Persons;Physicians;Population;Population Sciences;prevent;programs;Publications;Recording of previous events;recruit;Research;Research Personnel;Resource Sharing;Resources;Role;Scientist;Screening for cancer;Services;Source;Strategic Planning;synergism;Technology;therapy resistant;Training;Training and Education;Translating;Translational Research;Universities;Vision;Work;Workplace;Yale Cancer Center

PROJECT_TITLE: Immune Dysfunction in HIV associated Lung Cancer (Immuno/Microenvironment)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Pediatric;Rehabilitation

ORG_CITY: BOSTON

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE For the 1 in 700 babies in the United States that are born with Down syndrome, developing motor skills earlier may improve development in other domains, such as language and cognition. This study will use new, remote assessment methods to identify predictors of crawling and walking milestones in infants with Down syndrome. The results of this study will facilitate the development of personalized rehabilitation plans for infants with Down syndrome while considering limited resources.

PI_NAMEs: COLLIMORE, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Achievement;Address;Age;Alberta province;Caregivers;Child;Clinical;Clinical assessments;Code;Cognition;Collection;Computer software;cost effective;Data Collection;Development;Down's Syndrome;Ecological momentary assessment;Equipment;Evaluation;Exhibits;Frequencies;Gestures;Home;Human Resources;improved;Individual;Infant;insight;Intervention;Joints;kinematics;Laboratory Research;Language;Leg;Location;Locomotion;Measures;Mentors;Methods;Mobility decline;Motion;Motor;Motor Skills;Movement;novel strategies;Outcome;Outcome Measure;Outpatients;Pattern;personalized care;Persons;Play;Population;Positioning Attribute;Posture;prevent;recruit;rehabilitation paradigm;Rehabilitation therapy;remote assessment;Reporting;Research;Research Personnel;Research Project Grants;research study;Resource Allocation;Resource Sharing;Resources;sensor;skills;Social Interaction;success;Surveys;Techniques;Time;Training;Translating;Translational Research;Travel;United States;United States National Institutes of Health;Universities;usability;Walking;Work

PROJECT_TITLE: Moving Forward: Early Predictors of Crawling and Walking in Infants with DS


ADMINISTERING_IC: JG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: Global Health Center

ORG_CITY: Framingham

ORG_NAME: KEPHERA DIAGNOSTICS, LLC

PHR: PROJECT NARRATIVE This project is focused on the development of a new point-of-care testing technology that will provide an alternative to the conventional lateral flow technology that is currently the most common method used for detecting antibodies or antigens as markers of disease. The new method promises to simplify the development and production of point-of-care tests, thereby making these previously esoteric specialties broadly available to a broader community of assay developers and users. The current project will establish the feasibility of the new technology through demonstration of its application to rapid diagnostic testing for Chagas disease as an example of the many diagnostic and other testing applications foreseen.

PI_NAMEs: LEVIN, ANDREW E. (contact)

PROJECT_TITLE: MiCRIA: Two-minute rapid assay platform for point-of-care diagnosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-B (13)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE Tobacco use disorder disproportionally affects patients with serious mental illness. Our research shows that over the last decade, racial and ethnic minorities with serious psychological distress sustained high rates of smoking -- in sharp contrast to Whites, who experienced a significant decline. This Independent Scientist Award will provide training and protected time to focus on a program of research that develops and implements treatments addressing this important health inequity.

PI_NAMEs: VILARDAGA, ROGER  (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Abstinence;addiction;Address;Adopted;Adoption;Affect;Ancillary Study;Area;Award;behavioral health;Black Populations;Black race;Characteristics;Cigarette;Clinic;Clinical;Clinical Investigator;Clinical Trials;Collaborations;Communities;community advisory board;community consultation;Control Groups;cost effectiveness;Counseling;Data;Data Set;design;Development;Devices;digital;digital divide;digital intervention;digital treatment;Drug usage;Effectiveness;efficacy evaluation;efficacy testing;efficacy trial;Enrollment;Epidemiology;Equity;ethnic disparity;ethnic minority;ethnic minority status;Ethnic Origin;experience;Future;Goals;Health;health data;health equity;Health equity research;health inequalities;Health Services Accessibility;implementation evaluation;implementation facilitators;implementation framework;implementation science;Independent Scientist Award;Individual;informant;Interview;K-Series Research Career Programs;Laboratories;Latino;Latino Population;Learning;Link;Literature;Maintenance;Marketing;Measures;Mental disorders;Mentors;Mentorship;Methodology;Methods;Minority;Modeling;Not Hispanic or Latino;novel;Outcome;outreach;Parents;Patient Representative;Patients;Population;population health;pragmatic trial;Program Evaluation;programs;Protocols documentation;psychological distress;Quality of life;quitline;Race;racial disparity;racial minority;racism;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Research;Research Design;Research Personnel;Sampling;scale up;Scientist;severe mental illness;Site;Smoker;Smoking;smoking cessation;Socioeconomic Factors;Surveys;Technology Transfer;Testing;Therapeutic Intervention;Therapeutic Uses;Time;Tobacco Control Research;Tobacco use;Tobacco Use Disorder;Training;Translating;trial design;user centered design;Voice;Work

PROJECT_TITLE: Increasing the health equity and population-level impact of a digital therapeutic for smokers with psychiatric illness

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: OTHER BASIC SCIENCES

PHR: ADMINISTRATIVE SUPPLEMENTS - THE HARC CENTER 2.0: HIV ACCESSORY AND REGULATORY COMPLEXES PROJECT NARRATIVE The following three supplements will support the HARC Center’s mission of using its powerful “Systems-to- Structure” platform to uncover HIV-host protein interactions and develop a comprehensive understanding of how HIV rewires the host cellular machinery and of key disease processes.

PI_NAMEs: KROGAN, NEVAN J (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Administrative Supplement;Affinity Chromatography;Artificial Intelligence;Atlases;Automation;Biochemical;C-terminal;CD4 Positive T Lymphocytes;Cell Culture System;Cell Culture Techniques;Cell Line;Cells;cellular engineering;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Communities;Complex;cost;Coupled;CRISPR-mediated transcriptional activation;Cryoelectron Microscopy;Data;Decision Making;Development;Devices;Direct Costs;Disease;Ensure;Epitopes;Equipment;Event;Facilities and Administrative Costs;Family member;feeding;Funding;Generations;Genetic;Genetic Transcription;Genome engineering;genome-wide;Goals;HIV;HIV-1;HIV/AIDS;Human;human data;image guided;imager;Immune;Incubators;innovation;insight;Investigation;Knock-out;Liquid substance;Macrophage;Maps;Mass Spectrum Analysis;Mediating;Methods;Mission;Molecular;novel;novel therapeutic intervention;overexpression;particle;Physiological;Polyproteins;Process;protein complex;protein protein interaction;protein structure;Protein-Protein Interaction Map;Proteins;Proteome;Proteomics;reconstitution;Research Personnel;Resources;structural biology;Structure;System;Technology;Time;tool;Validation;Viral

PROJECT_TITLE: Equipment and Administrative Supplement- THE HARC CENTER 2.0: HIV ACCESSORY AND REGULATORY COMPLEXES


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Heart Disease;Hematology;Infectious Diseases;Prevention;Rare Diseases;Sepsis

PHR: Project Narrative Current prevention protocols for people at risk for infective endocarditis (IE) focus on antibiotic prophylaxis prior to invasive dental office procedures for only 10% of people at risk for this life- threatening disease. Although a high percentage of cases of IE are caused by bacterial species from the mouth, there are only informal guidelines on prevention for the remaining 90% of people at risk. This study will determine if improved oral hygiene and reduction of gingival inflammation decrease the incidence and duration of bacteremia of IE-causing oral species, which would refocus longstanding guidelines on prevention for all people at risk for IE.

PI_NAMEs: LOCKHART, PETER B (contact)

PROGRAM_OFFICER_NAME: FISCHER, DENA

PROJECT_TERMS: Address;Antibiotic Prophylaxis;Bacteremia;Blood;Blood Circulation;Calculi;Cardiac;clinical practice;Clinical Trials;Data;dental biofilm;Dental Calculus;Dental Hygiene;Dental Offices;Dental Plaque;Development;Disease;Educational Intervention;Enrollment;Frequencies;Funding;Funding Agency;Gingiva;Goals;group intervention;Guidelines;Health;healthcare community;Heart Valves;Hospitalization;improved;Incidence;Infective endocarditis;Inflammation;Instruction;Intervention;Life;Measures;Morbidity - disease rate;mortality;Mouth Diseases;National Institute of Dental and Craniofacial Research;novel;Oral;oral care;Oral cavity;Participant;Pathway interactions;Patients;Persons;Populations at Risk;Practice Guidelines;Prevention;Prevention Guidelines;Prevention Protocols;Preventive care;Preventive measure;Procedures;Prospective Studies;Randomized;randomized trial;Reporting;Risk;Risk Factors;Risk Marker;Risk Reduction;Solid;Step Tests;Surrogate Markers;Testing;Time;Toothbrushing;treatment group;universal prevention;Work

PROJECT_TITLE: Randomized Trial of non-Surgical Therapy and Oral Hygiene Instruction to Reduce Risk of Infective Endocarditis


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Pediatric;Prevention;Rare Diseases;Tuberculosis;Women's Health Research

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative The Botswana Clinical Trials Unit will develop and study strategies for preventing and treating HIV infection and HIV-related illnesses, including tuberculosis, that are relevant to the severe HIV epidemic in sub-Saharan Africa and elsewhere. This will include studies of novel and durable HIV treatment in HIV-infected adults, including pregnant women, and children; strategies to induce antiretroviral-free HIV remission (or eradication) in adults and children; new treatments and prevention approaches for tuberculosis in adults, including pregnant women, and children; and HIV prevention strategies, including pre-exposure prophylaxis and integrated prevention approaches.

PI_NAMEs: LOCKMAN, SHAHIN  (contact);MAKHEMA, JOSEPH MOEKETSI

PROGRAM_OFFICER_NAME: GUBB, STEPHANIE MAJER

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adult;Africa South of the Sahara;Age;AIDS clinical trial group;AIDS prevention;Anti-Retroviral Agents;Area;Botswana;Capital;Child;Childhood;Cities;Clinical Research;Clinical Trials Unit;co-infection;Disease remission;Epidemic;HIV;HIV Infections;Infection;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;Modality;Multicenter Studies;novel;participant enrollment;pediatric human immunodeficiency virus;Population;pre-exposure prophylaxis;Pregnant Women;prevent;Prevention;Prevention approach;Prevention strategy;Protocols documentation;Public Health Schools;Research;research study;Resources;sex;Therapeutic;Tuberculosis;Work

PROJECT_TITLE: Botswana-Harvard T.H. Chan School of Public Health AIDS Initiative Partnership CTU Y18 Supplement


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention;Women's Health Research

ORG_CITY: Manassas

ORG_NAME: SERPIN PHARMA, LLC

PHR: Narrative Chemotherapy-induced peripheral neuropathy (CIPN) is a significant clinical challenge affecting many cancer patients and survivors with no approved treatments to target the root causes of CIPN effectively. Serpin Pharma’s SP16, a novel LRP1 agonist, is a highly potent anti- inflammatory and neuro-protectant drug, that repairs nerve injury and ameliorates pain, creating a revolutionary complete solution for CIPN. The overall goal of this project is to advance the development of SP16 through a Phase 1b clinical trial as a preventative strategy in CIPN, offering a unique approach and a commercially viable opportunity to address an unmet need for cancer patients.

PI_NAMEs: AUSTIN, DANA E.;GELBER, COHAVA  (contact)

PROGRAM_OFFICER_NAME: TRIPURANI, SWAMY KRISHNA

PROJECT_TERMS: Acute;Address;Advanced Development;Adverse effects;Affect;Agonist;Analgesics;analytical method;Anti-Inflammatory Agents;Antibodies;anticancer activity;appropriate dose;Biological Assay;Biological Availability;Bone Marrow;Breast;Breast Cancer Patient;Cancer Patient;cancer survival;Cancer Survivor;Cell model;Cells;chemotherapy;Chemotherapy-induced peripheral neuropathy;Chinese Hamster;Chromosome abnormality;chronic pain;Clinical;clinical practice;Clinical Research;Clinical Trials;clinically relevant;commercialization;Complex;COVID-19 patient;Data;Diagnosis;Dose;Dose Limiting;Drug Approval;drug development;Drug usage;duloxetine;effective therapy;European Organization for Research and Treatment of Cancer;Food and Drug Administration Drug Approval;Functional disorder;functional outcomes;Future;Genetic;genotoxicity;Glucose;Goals;Guidelines;Health;healthcare burden;Hospitalization;Immune response;Impairment;improved;In Vitro;in vivo;Inflammation;Injury;Intravenous infusion procedures;Investigational Drugs;Licensing;Malignant Breast Neoplasm;Malignant Neoplasms;manufacture;MDA MB 231;Medical;method development;Micronucleus Tests;Modeling;mouse model;nerve damage;nerve injury;nerve repair;Nervous System Physiology;Neuropathy;Neuroprotective Agents;neurotoxic;Non-Small-Cell Lung Carcinoma;novel;Nude Mice;off-label use;Oncologist;Oncology;Outcome;Ovarian;Paclitaxel;Pain;Pain management;Patient Outcomes Assessments;patient population;Patients;Peripheral nerve injury;Peripheral Nervous System Diseases;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Phase;phase 1 study;phase 2 designs;phase 2 study;phase 3 study;Phase Ib Clinical Trial;Phase Ib Trial;Phase II Clinical Trials;Phase III Clinical Trials;Plasma;Plasma Proteins;preclinical study;Prevalence;prevent;Prevention strategy;Preventive treatment;primary endpoint;Process;Prostate;Quality of life;Randomized;Rattus;Receptor Signaling;regenerative;Regimen;Reporting;Research Contracts;Safety;Sampling;screening;sensory neuropathy;Serpins;side effect;standard of care;Target Populations;taxane;Therapeutic;therapeutic target;Tissues;Toxic effect;Toxicology;translational model;tumor xenograft;University of Virginia Cancer Center;unnatural amino acids;Validation;Work;Xenograft Model

PROJECT_TITLE: A Novel LRP1 Agonist, SP16, as a Therapeutic Treatment in Preventing Chemotherapy-Induced Peripheral Neuropathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-S (14)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Pediatric;Suicide

ORG_CITY: PISCATAWAY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Adolescent mental health has been named a public health emergency, with rates of depression and suicide rising steadily. Social media (SM) is linked to negative mental health consequences for some adolescents but not others, and no studies to date have uncovered a modifiable target that could alter the course of negative mental health outcomes for affected adolescents. This NRSA project proposes to identify whether emotion regulation strategies—a widely used and effective target in existing clinical interventions—may contribute to these differential patterns and may be a candidate target for future adolescent SM/mental health interventions.

PI_NAMEs: DREIER, MELISSA J. (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Adolescent;adolescent mental health;Affect;Age;Anxiety;Behavior;Buffers;Cellular Phone;Clinical;Cognitive;Data Analyses;design;distraction;Ecological momentary assessment;Effectiveness;Elements;emotion regulation;Emotional;emotional experience;emotional reaction;Emotions;Equation;Evidence based intervention;Evidence based treatment;experience;Feeling;Feeling hopeless;Feeling suicidal;Frequencies;Future;Goals;Gravitation;High School Student;Individual;Individual Differences;Intervention;Link;Location;Measures;media use;Mental Depression;Mental Health;Methods;Modeling;Moods;multidimensional data;multilevel analysis;Names;National Research Service Awards;negative mood;Outcome;Outcome Study;Participant;Pathway interactions;Pattern;Persons;Problem Solving;public health emergency;recruit;Reporting;Research;response;Rewards;Risk;rumination;social;Social Environment;social media;Specificity;suicidal behavior;Suicide;Suicide attempt;Surgeon;Taxes;Teenagers;Testing;Thinking;Time;Training;tv watching;United States;Work;Writing

PROJECT_TITLE: Using Real-Time Methods to Investigate Emotion Regulation as a Modifiable Target Connecting Adolescent Social Media Use and Mood


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Contraception/Reproduction;Dementia;Estrogen;Menopause;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: ALBANY

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: PROJECT NARRATIVE There are currently no effective therapies to reduce vascular contributions to cognitive impairment and dementia (VCID). Over 80% of individuals with Alzheimer’s disease (AD) have underlying VCID pathology that contributes to dementia progression; this is known as multiple etiology dementia (MED). Our goals is to determine if an estrogen prodrug can be used as a preventative therapy, during either peri-menopause or menopause, to reduce VCID pathology and slow progression of MED.

PI_NAMEs: ZULOAGA, KRISTEN LEANNE (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: 3-Dimensional;abeta accumulation;Acceleration;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-Protein;apolipoprotein E-4;Blood Vessels;blood-brain barrier function;Brain;brain endothelial cell;Cell Physiology;Cells;Cerebral Amyloid Angiopathy;cerebral hypoperfusion;Cerebrovascular system;Chronic;Clinical;Clinical Data;cognitive function;Data;Dementia;dementia burden;Development;Dose;effective therapy;Endocrine;Endothelial Cells;endothelial stem cell;Endothelium;Estradiol;Estrogen Receptors;Estrogens;Female;Future;Genes;Genotype;Glucose Intolerance;Goals;Health;Hippocampus;Hormonal;hormone therapy;Human;human induced pluripotent stem cells;Impaired cognition;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inflammatory;insight;Intervention;Knock-in;MED15;Memory;Menopause;Metabolic;mixed dementia;Modeling;monolayer;Mus;Neurobehavioral Manifestations;neuropathology;Nitric Oxide;novel therapeutic intervention;Operative Surgical Procedures;ovarian failure;Parents;Pathologic;Pathology;Pathway interactions;Perimenopause;Phase;Postmenopause;Prevalence;Prevention strategy;Preventive therapy;Prodrugs;protective effect;Receptor Signaling;Resistance;response;RiboTag;Risk Factors;Senile Plaques;Signal Transduction;Testing;Therapeutic;therapeutic target;TNF gene;translatome;vascular cognitive impairment and dementia;vascular risk factor;Weight Gain;Woman

PROJECT_TITLE: Metabolic and Hormonal Mechanisms of VCID

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

PHR: PROJECT NARRATIVE Understanding how individuals seek and consume alcohol in the presence of alternative reinforcers is critical for understanding the progression from recreational drinking to alcohol use disorder given that six of eleven of the diagnostic criteria pertain to increase appetitive (seeking) and consummatory behaviors directed towards alcohol with concurrent decreases in these behaviors maintained by non-alcohol alternatives. The current proposal aims to investigate a circuit that may control alcohol choice behavior by using a novel operant self-administration choice paradigm that procedurally separates appetitive and consummatory facets of behavior. Particular focus will be directed towards understanding whether acute withdrawal from chronic alcohol exposure and sex as a biological variable result in differential effects on alcohol choice behavior.

PI_NAMEs: ORTELLI, OLIVIA  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acute;Address;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol related consequences;alcohol seeking behavior;alcohol use disorder;Alcohols;Animals;Appetitive Behavior;Behavior;Behavioral;Behavioral Mechanisms;behavioral outcome;Choice Behavior;Chronic;cohort;Consummatory Behavior;Consumption;Coupled;Data;Desire for food;diagnostic criteria;drinking;Electrophysiology (science);Ethanol;Ethanol dependence;experience;Extinction;Female;Genetic;Goals;Health;Hippocampus;Hour;Impairment;in vivo;increased appetite;Individual;insight;Intake;interdisciplinary approach;Literature;maladaptive behavior;male;Mediating;Modeling;neglect;neural circuit;Neurobiology;novel;Nucleus Accumbens;optogenetics;Outcome;Phenocopy;Phenotype;Play;Pre-Clinical Model;Procedures;Process;Rattus;Recreation;reinforcer;Relapse;response;Rodent;Role;Self Administration;sex;sex as a biological variable;Sex Differences;Societies;Sucrose;Symptoms;Synapses;Techniques;Testing;Therapeutic;therapeutic target;Training;translational model;vapor;Withdrawal;Work

PROJECT_TITLE: Assessing the contributions of the ventral subiculum to the nucleus accumbens shell projection in a novel ethanol self-administration choice paradigm

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Immunotherapy;Radiation Oncology;Rare Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The identification of mechanisms responsible for poor response to epidermal growth factor receptor (EGFR) inhibitors in HNSCC is warranted in order to harness the beneficial properties of these agents. This grant application tests if NOX2 redox activity and IL-8 signaling contribute to poor long-term anti-tumor response to EGFRIs via increased IL-1 signaling in RT-treated HNSCC tumors. We expect that this application will discover novel mechanisms and possibly lead to promising new therapeutic approaches for HNSCC patients.

PI_NAMEs: BURNETT, ANDREAN LLEWELA (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: African American;angiogenesis;anti-cancer research;Antitumor Response;Applications Grants;autocrine;Cell Line;Cell Proliferation;Cells;Cetuximab;chemoradiation;Cisplatin;Clinical Trials;clinically relevant;Communities;Consensus;cytokine;Data;Diagnosis;Disease;Disease Progression;Drug resistance;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;equity, diversity, and inclusion;experience;Failure;FDA approved;Head and Neck Squamous Cell Carcinoma;high risk;Holden Comprehensive Cancer Center at the University of Iowa;Human;IL1A gene;IL8RA gene;Immune checkpoint inhibitor;Immunocompetent;immunodeficiency;Immunotherapy;improved;Inflammation;Inflammatory;Interleukin-1;Interleukin-1 alpha;Interleukin-8;Investigation;Laboratories;Lead;Ligands;Macrophage;Mediating;Mission;Monitor;mouse model;Mutation;NADPH Oxidase;National Institute of Dental and Craniofacial Research;neoplastic cell;neutrophil;Neutrophil Infiltration;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Oncogenes;Oncogenic;Operative Surgical Procedures;Oxidation-Reduction;Oxidative Stress;paracrine;Pathway interactions;Patients;Pharmaceutical Preparations;Postoperative Period;Production;Property;Protocols documentation;Radiation therapy;Receptor Activation;Receptor Cross-Talk;Receptor Inhibition;Receptor Signaling;recruit;Recurrent disease;Recurrent tumor;Reporting;Research;Research Personnel;Resistance;resistance mechanism;response;Role;Signal Pathway;Signal Transduction;standard of care;Superoxides;survival outcome;Testing;tumor;tumor microenvironment;tumor-immune system interactions;Work

PROJECT_TITLE: Inflammation and EGFR crosstalk in HNSCC Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-K (50)]


PHR: PROJECT NARRATIVE The transition from initial to problematic alcohol use occurs within a subset of individuals; thus, evaluating individual variability in punished alcohol seeking models can reveal why some individuals abstain from alcohol use in the presence of negative consequences while others persist. The orbitofrontal cortex is a neural substrate that modulates action selection and action contingencies. The proposed project seeks to explore contributions of the orbitofrontal cortex in the individual variability to seek alcohol despite negative consequences as well as dissect the behavioral features of punished alcohol seeking.

PI_NAMEs: SOTO, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Affect;alcohol abstinence;Alcohol abuse;Alcohol consumption;alcohol exposure;alcohol reward;alcohol seeking behavior;alcohol use disorder;Alcohols;Behavior;Behavioral;behavioral impairment;behavioral response;Calcium;career;Characteristics;Chemosensitization;Chronic;Classification;Decision Making;design;Detection;drinking;drinking behavior;Event;experimental study;Financial Hardship;flexibility;foot;genetic manipulation;Goals;Health;Image;Impairment;in vivo;in vivo calcium imaging;Individual;Individual Differences;individual variation;Knowledge;Learning;Mediating;Microscope;Minority Groups;Modeling;Motivation;neural;neural correlate;Neurobiology;Neurons;Neurosciences;Nose;optogenetics;Outcome;Outcome Assessment;pharmacologic;Pre-Clinical Model;Prefrontal Cortex;Process;Punishment;Rattus;Research;Resistance;response;Reversal Learning;Rewards;Role;Self Administration;Shock;skills;Slice;social;Specific qualifier value;Stimulus;Testing;Time;time use;Training;Update;Work

PROJECT_TITLE: Role of Orbitofrontal Cortex in Maladaptive Ethanol Seeking


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Infectious Diseases;Lung;Lung Cancer;Lymphatic Research;Lymphoma;Orphan Drug;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: Columbus

ORG_DEPT: SURGERY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The Ohio State University Comprehensive Cancer Center (OSUCCC) is a matrix cancer center that integrates and leverages all of the resources of the University to achieve its broad vision of creating a cancer free world. The OSUCCC addresses the public health needs of the catchment area (the state of Ohio) through research, education and community outreach and engagement as research conducted within the five OSUCCC Programs focuses on high priority cancers for the OSUCCC including lung, breast, colorectal, prostate, endometrial, cervical cancer, thyroid, and leukemia, as well as tobacco use, obesity, and HPV vaccination. Screening and outreach activities are provided to the populations across the lifespan that we serve, especially those with higher burden of being diagnosed with cancer, such as racial/ethnic minorities and other underserved populations (e.g., rural, LGBTQ+, Appalachian) through targeted, culturally appropriate education activities, free cancer screenings, patient navigation, community networking, environmental scans, and addressing policy issues.

PI_NAMEs: BAIOCCHI, ROBERT ALAN;LI, ZIHAI ;POLLOCK, RAPHAEL E. (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Address;Africa South of the Sahara;AIDS Malignancy Consortium;AIDS related cancer;AIDS-Related Diffuse Large B-cell Lymphoma;AIDS-Related Lymphoma;angiogenesis;anti-cancer research;anticancer activity;Appalachian Region;Attention;attributable mortality;Basic Science;Behavior;Biological;Biology;Breast;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Etiology;cancer genetics;cancer prevention;cancer research center director;Cancer Survivorship;Catchment Area;CD86 gene;Cessation of life;Chemoprevention;Classification;Clinical;clinical development;Clinical Research;Clinical Trials;cohort;Colorectal;Combined Modality Therapy;Community Networks;Community Outreach;Comprehensive Cancer Center;Data;Descriptor;Developed Countries;Development;Diagnosis;Disease;Disparity;Doctor of Philosophy;Education and Outreach;Educational Activities;Endometrial;Engineering;Epidemic;ethnic minority;Etiology;Evaluation;Event;experience;Extranodal;Faculty;FDA approved;Flow Cytometry;Fostering;Funding;General Population;Growth;Healthcare;Hematologic Neoplasms;Hematopoietic Neoplasms;Herpesviridae;high risk;HIV;HIV Infections;HIV/AIDS;Human;Human Herpesvirus 4;Human Papilloma Virus Vaccination;IL6 gene;Immune;Immune Evasion;Immune System Diseases;Immunologics;Immunooncology;improved outcome;in vivo;Infiltration;innovation;insight;Institution;interdisciplinary approach;Intervention;Investigational Therapies;Investments;Journals;large cell Diffuse non-Hodgkin's lymphoma;Leadership;Lesbian Gay Bisexual Transgender Queer;leukemia;life span;low and middle-income countries;Lung;Lymphoma;Lymphoma cell;Macrophage;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Manuscripts;member;Methods;Minority Groups;Mission;Modeling;Molecular;Molecular Biology;Molecular Carcinogenesis;Morbidity - disease rate;mortality;mortality risk;Multicultural Education;Nature;next generation;Non-Hodgkin's Lymphoma;novel;Obesity;Ohio;Oncogenic;Oncogenic Viruses;Outcome Study;outreach;patient navigation;Patients;Peer Review;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Policies;Population;Population Research;Population Sciences;pre-clinical;Pre-Clinical Model;preclinical development;Prevention;Prognosis;Prognostic Factor;programmed cell death ligand 1;programs;Prostate;Proteins;Public Health;Publications;Publishing;racial diversity;racial minority;recruit;Regulatory T-Lymphocyte;Research;Resolution;Resource Sharing;Resource-limited setting;Risk;Rural;S-Phase Fraction;Scanning;Scientist;screening;Screening for cancer;single-cell RNA sequencing;Site;Solid Neoplasm;Strategic Planning;survivorship;targeted agent;Technology;Therapeutic;Therapeutic Agents;Therapeutic Trials;therapeutically effective;Thyroid Gland;Tissues;Tobacco use;Training;transcriptomics;Transforming Growth Factor beta;Translating;translational genomics;Translational Research;translational therapeutics;treatment response;tumor;Tumor Burden;tumor microenvironment;tumor-immune system interactions;Underserved Population;United States;Universities;University resources;Vision

PROJECT_TITLE: Targeting the Tumor Microenvironment in Patients with AIDS-Associated EBV+ Diffuse Large B Cell Lymphoma


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Genetic Testing;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Hypertension;Kidney Disease;Mental Health;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Project Narrative: Pain and depression affect large percentages of the population and identifying the optimal medication for an individual can be challenging, so this trial will determine whether using genetic information to inform selection of opioids or antidepressants leads to better clinical outcomes for patients. People with African ancestry (AAs) have the highest rates of uncontrolled high blood pressure, chronic kidney disease and kidney failure, some of which is due to APOL1 genetic variants. We will test AA adults with high blood pressure for APOL1 and return the results to patients and their clinicians, to see if early knowledge of high genetic risk improves blood pressure, provider and patient behaviors and is cost effective.

PI_NAMEs: CAVANAUGH, KERRI ;PETERSON, JOSEPH F. (contact)

PROGRAM_OFFICER_NAME: VOLPI, SIMONA

PROJECT_TERMS: Acute;Acute Pain;Adult;Adverse effects;Affect;African American population;African ancestry;anti-depressive agents;APOL1 gene;Behavior;Biological;Blood Pressure;blood pressure control;Chronic Kidney Failure;chronic pain;Clinical;Clinical Trials;Clinical Trials Network;clinically relevant;cost effective;cost effectiveness;Data;demographics;Diagnosis;Disparity;economic impact;effective therapy;genetic information;Genetic Risk;genetic testing;genetic variant;Genomic medicine;Genotype;Guidelines;Health;health care service utilization;health difference;Healthcare;High Prevalence;high risk;Hypertension;hypertension control;improved;Individual;Kidney;Kidney Failure;Knowledge;Mental Depression;Opiate Addiction;Opioid;Outcome;Pain;Pain management;Participant;Patient Outcomes Assessments;patient population;Patient-Focused Outcomes;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;pharmacogenetic testing;Pharmacogenetics;Pharmacotherapy;Pilot Projects;Population;Population Heterogeneity;Postoperative Pain;primary endpoint;prospective;Provider;Randomized;recruit;Risk;risk minimization;Safety;secondary analysis;secondary outcome;Selection for Treatments;social determinants;Testing

PROJECT_TITLE: Integrated, Individualized, and Intelligent Prescribing (I3P) Clinical Trial Network


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative  Alzheimer's disease is one of the most common and progressive genetic neurodegenerative disorders in the US with more than 5 million people currently living with Alzheimer's disease and women are more likely to develop a rapid progression of Alzheimer's disease, than men when predictive factors such as obesity, lifespan, and enhanced stroke severity are considered. We propose to use a targeted non-invasive photobiomodulation (laser) therapy to decrease protein arginine methyltransferase 4 in Alzheimer's disease and related vascular dementias. Photobiomodulation (through the modulation of protein arginine methyltransferase 4) can combat cerebral hypoperfusion/vascular tonicity and neurovascular uncoupling in mouse models of Alzheimer's disease.

PI_NAMEs: LIN, HUNG WEN (KEVIN)  (contact);ZHANG, QUANGUANG

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: 3xTg-AD mouse;Age;aged;Alternative Therapies;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Area;Attenuated;behavioral outcome;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;brain metabolism;Cell Adhesion Molecules;cerebral hypoperfusion;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Circulation;clinically relevant;combat;Coupled;cranium;Data;Development;Diameter;discrimination task;Disease;Disease Progression;Embryo;Enzymes;Extravasation;Family;Female;functional improvement;Genetic;Goals;Human;hypoperfusion;Immunity;Impairment;improved;Inflammation;innovation;Investigation;Ischemia;knock-down;Knockout Mice;Knowledge;Laser Scanning Microscopy;Laser Speckle Imaging;Lasers;Learning;Leucocytic infiltrate;Leukocyte Rolling;life span;Light;male;Malignant Neoplasms;Measures;Mediating;Memory;Memory impairment;men;Messenger RNA;Methylation;Modality;mouse model;Mus;Nervous System Disorder;Neurodegenerative Disorders;neurovascular;neurovascular coupling;Nitric Oxide;NOTCH1 gene;novel;Obesity;object recognition;occludin;Pathway interactions;Patients;Penetration;Perfusion;Persons;pharmacologic;photobiomodulation;Physical therapy;Predictive Factor;preservation;prevent;Protein Inhibition;Protein-Arginine N-Methyltransferase;Proteins;Regulatory Element;response;Risk Factors;Rodent Model;Role;Severities;sex;Signal Transduction;Stroke;System;Texture;Therapeutic;Tight Junctions;two-photon;Vascular Cognitive Impairment;Vascular Dementia;Vibrissae;Woman

PROJECT_TITLE: Using Photobiomodulation to Alleviate Brain Hypoperfusion in Alzheimer's Disease


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;HIV/AIDS;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative- Relevance This proposed research is relevant to public health because it involves the development of a novel therapeutic approach and model development to combat the increasing incidents of HPV-associated malignancies in people living with HIV (PLH). By developing this innovative intervention, this project will meet part of the NIH’s mission by reducing illness in this group of vulnerable individuals.

PI_NAMEs: CARPTEN, JOHN D. (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Age;AIDS related cancer;angiogenesis;anti-cancer;anti-cancer research;Antineoplastic Agents;antiretroviral therapy;Architecture;Biological;Biological Models;Blood;Blood - brain barrier anatomy;Cancer Model;cancer therapy;Cell Communication;Cells;Cervical;Chronic;co-infection;cohort;combat;Development;Diagnosis;Dose;Ecosystem;Environment;exosome;extend lifespan;extracellular vesicles;Goals;Head and Neck Cancer;Head and Neck Neoplasms;Head and neck structure;High Prevalence;HIV;HIV Infections;HPV-High Risk;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;humanized mouse;Immune;Immune System Diseases;Immunocompetent;immunogenic;In Vitro;in vivo;in vivo Model;Incidence;Individual;Inflammation;innovation;Intervention;Investigation;Life Expectancy;Liver;Maintenance;Malignant neoplasm of anus;Malignant Neoplasms;Mission;model development;Modeling;Molecular Target;mortality;mouse model;Mus;nanoparticle;next generation;novel;novel therapeutic intervention;Oncogenes;Oncogenic Viruses;Oncornaviruses;particle;Pathogenesis;Pathology;Pathway interactions;patient derived xenograft model;Patients;Persons;Predisposition;prevent;Public Health;Research;RNA Interference;RNA Interference Therapy;Sampling;side effect;small hairpin RNA;Solid;Solid Neoplasm;Source;Study models;System;Therapeutic;therapeutic development;therapeutic gene;therapy resistant;tool;Toxic effect;tumor;tumor progression;United States National Institutes of Health;uptake;Validation;Viral;Viral Oncogene;Viremia;Virus Diseases;Virus Inactivation;virus related cancer;Vulnerable Populations;Work

PROJECT_TITLE: Novel 'all-in-one' EV delivered RNAi treatment for NADCs within representative HIV patient models in humanized mice (Biospecimen/Cohort)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Social Determinants of Health;Substance Misuse

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Recovery from alcohol use disorder (AUD) is common in the United States, and many of those in AUD recovery are employed. However, research is lacking on the impact of workplace factors on recovery and their interaction with factors already known to influence recovery outcomes. The proposed research will be among the first to investigate links between workplace factors, recovery, and related outcomes to determine whether the ability of individuals to successfully initiate and maintain recovery varies as a function of their work environments and the supports provided therein.

PI_NAMEs: WILLIS, MAIREAD A. (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Abstinence;addiction;Adult;Affect;alcohol consequences;Alcohol consumption;alcohol use disorder;Alcohols;Award;Basic Science;Behavior;behavior change;Behavioral Mechanisms;behavioral study;biopsychosocial;Capital;Cardiovascular system;Characteristics;college;Consumption;contextual factors;craving;Data;Data Collection;design;Ecological momentary assessment;economic cost;Educational workshop;Elements;Employment;Enabling Factors;Environment;environmental intervention;evidence base;Evidence based intervention;Face;Funding;Future;Goals;Government Agencies;Grant;heart rate variability;Home;Individual;Institution;Intervention;Investigation;Length;Life;Link;Longitudinal Studies;Maintenance;meetings;Mentorship;Methods;Missouri;Modeling;Motivation;National Institute on Alcohol Abuse and Alcoholism;negative affect;neglect;Outcome;Participant;Patient Self-Report;Persons;physical conditioning;Physiological;Positive Reinforcer;Process;productivity loss;professional atmosphere;programs;Proliferating;protective factors;psychologic;Psychology;Recovery;recruit;Recurrence;reduced alcohol use;Reporting;Research;Research Design;Resources;Risk Factors;Ritual compulsion;Sampling;Self Efficacy;Social Controls;social exclusion;statistics;stem;Stigmatization;substance use;Substance Use Disorder;symposium;Symptoms;Testing;theories;Time;Training;Treatment outcome;United States;Universities;Vocation;wearable device;Work;Workplace

PROJECT_TITLE: Ecological mechanisms for Alcohol Use Disorder recovery in workplace contexts


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Alcohol use disorder (AUD) is a debilitating condition with poor long-term treatment outcomes, despite effective treatments for initial recovery. A common cause of relapse is anxiety that develops during abstinence, where individuals use alcohol for its negative reinforcing properties to remove anxiety that they experience. This project aims to better understand changes in negative reinforcement behaviors and their associated neural network during early abstinence from an AUD.

PI_NAMEs: ZABIK, NICOLE LAUREN (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Abstinence;addiction;Address;Adult;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol exposure;alcohol relapse;alcohol research;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;American;Amygdaloid structure;Animal Experimentation;Animal Model;Animals;Anterior;Anxiety;anxiety symptoms;Behavior;Behavioral;Behavioral Mechanisms;biological adaptation to stress;Brain;brain behavior;Brain region;career;Chronic;chronic alcohol ingestion;cingulate cortex;Collaborations;comparison control;Control Groups;Corpus striatum structure;Cues;Darkness;depressive symptoms;Development;Diffusion Magnetic Resonance Imaging;Dimensions;Disabling condition;Dorsal;effective therapy;Emotional;Emotions;Equilibrium;Exhibits;experience;Foundations;Future;Galvanic Skin Response;Goals;Homeostasis;Human;Individual;Individual Differences;Knowledge;Learning;Measures;Mediating;Mental Depression;Mentorship;Modeling;Motivation;negative affect;Negative Reinforcements;neural circuit;neural network;neurobehavioral;neuromechanism;Outcome;Participant;Positive Reinforcements;Positive Reinforcer;pre-clinical;Prevention;Prevention strategy;Process;programs;Property;Psychological reinforcement;Reaction Time;Recovery;Relapse;relapse patients;relapse prevention;Reporting;Research;Research Design;Research Personnel;response;Rest;Rewards;Rodent;Role;Side;Stress;Structure of terminal stria nuclei of preoptic region;Symptoms;System;Testing;theories;Training;Translating;Translations;Treatment outcome

PROJECT_TITLE: Negative reinforcement in early abstinence from an alcohol use disorder


NIH_SPENDING_CATS: Hearing Loss;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Neuronal adaptation to the current environment is vital to sensory perception, especially in noisy environments where the relevant signal is obscured by noise. People with various types of hearing impairments, including age- related hearing loss, struggle disproportionately to understand speech in noisy environments, impairing their ability to communicate with others and negatively impacting their quality of life. The proposed research will further our understanding of the neuronal circuits involved in separating signal from noise and will lead to new treatment approaches for these patient groups.

PI_NAMEs: ZELIGER, OMER  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acoustics;Auditory;Auditory area;Auditory Perception;auditory processing;Auditory system;Automobile Driving;behavior prediction;Behavioral;Cells;Coffee;Communication;Communication difficulty;Consumption;Data;Detection;effective therapy;Electrophysiology (science);Environment;excitatory neuron;Exposure to;extracellular;flexibility;forest;Goals;Hearing;hearing impairment;Human;Impairment;Interneurons;Knowledge;Libraries;Life;Linear Models;Measures;Mediating;Motivation;Mus;neuronal circuitry;Neurons;Noise;novel therapeutic intervention;Opsin;optogenetics;Parvalbumins;Patients;Perception;Persons;Positioning Attribute;Presbycusis;Process;Property;Quality of life;Research;Research Proposals;response;Response Latencies;Risk;Role;Sensory;Shapes;Signal Transduction;Somatostatin;sound;Speech;statistics;Stimulus;Synapses;Testing;Training;Wing;Work

PROJECT_TITLE: Cortical mechanisms for contrast gain control in auditory perception in noise.


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Kaposi sarcoma (KS) is a cancer caused by a virus called KSHV that occurs frequently in individuals with HIV infection, and KS may lead to death despite treatment. This study will assess how interactions between KSHV, HIV, and host immune responses in KS tumors before and during treatment influence KS clinical outcomes, which could ultimately lead to new therapies for the treatment of KS.

PI_NAMEs: LYNCH, THOMAS JAMES (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Address;Adult;AIDS with Kaposi's sarcoma;antiretroviral therapy;biobank;Biological;Biopsy;Blood;Cancer Center Support Grant;Cancer Etiology;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Cessation of life;chemotherapy;Clinic Visits;Clinical;co-infection;cohort;Data;design;Disease remission;effective therapy;Enrollment;exome sequencing;Gene Expression;gene product;Genes;Genetic Transcription;Goals;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;Human Herpesvirus 8;Immune;immune cell infiltrate;Immune response;Immunohistochemistry;improved;Individual;Kaposi Sarcoma;Link;Lytic;Macrophage;Malignant Neoplasms;Mediating;Morbidity - disease rate;mortality;Mutation;Newly Diagnosed;novel therapeutics;Oncogenic;Oral;Outcome;partial response;Participant;Pathogenesis;Persons;Plasma;Play;Progressive Disease;prospective;Recurrence;Refractory;Resistance;response;Role;Saliva;Sampling;Shapes;Somatic Mutation;spatial relationship;Specimen;survival outcome;Swab;T-Lymphocyte;targeted treatment;therapy resistant;Time;transcriptome;transcriptome sequencing;treatment optimization;Treatment outcome;treatment response;tumor;tumor microenvironment;Tumor-Infiltrating Lymphocytes;tumorigenesis;Uganda;Viral;Viral Genes;Viral Load result;Virus

PROJECT_TITLE: CCSG Supplement: Identifying Mechanisms of Treatment Resistance and Response in Kaposi Sarcoma (Biospecimen/Cohort)


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Sleep Research

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Autism spectrum disorder (ASD) is a common neurological disorder often associated with sleep disturbances; however, it is unclear why this association exists. Human variants in the Neuroligin 3 (NLGN3) gene have been identified in patients diagnosed with both ASD and sleep disorders, and loss-of-function studies have shown impairments in synaptic endocytosis. The goal of this project is to determine if NLGN3 variants impair the endocytosis of synaptic vesicles to contribute to ASD and sleep behaviors, thus providing a possible mechanism for the comorbidity between ASD and sleep.

PI_NAMEs: TOWNSLEY, REBEKAH ELISE (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Affect;Alleles;autism spectrum disorder;Behavior;Behavioral;Behavioral Assay;behavioral study;Binding;Biological Assay;Cell Adhesion Molecules;Child;Circadian Rhythms;Classification;comorbidity;Complementary DNA;Courtship;Databases;Defect;Development;Diagnosis;Disease;Drosophila genus;Dyes;Endocytosis;Endocytosis Inhibition;Etiology;Exhibits;Family;Female;fly;Foundations;gain of function;Gene Family;Genes;Genetic Heterogeneity;genome wide association study;Glutamates;Goals;Grooming;Heterozygote;Human;Impairment;in vivo;Individual;Inherited;insight;interest;Knock-in Mouse;Lead;Length;Lifestyle-related condition;Link;Locomotion;loss of function;male;Measures;Methods;model organism;Molecular;Morphology;mouse model;Mus;mutant;Nervous System Disorder;neural;neural circuit;Neurites;Neurodevelopmental Disorder;neuroligin 3;Neuromuscular Junction;novel;Orthologous Gene;overexpression;Pathogenesis;Patients;Pattern;Phenotype;Play;Population;postsynaptic;presynaptic;Presynaptic Terminals;Proteins;receptor;repetitive behavior;Research;Role;Sleep;sleep abnormalities;sleep behavior;Sleep Deprivation;Sleep Disorders;Sleep disturbances;social communication impairment;social deficits;Structure;Synapses;Synaptic plasticity;Synaptic Transmission;Synaptic Vesicles;synaptogenesis;Testing;Therapeutic;United States;uptake;Variant;variant of interest;Vesicle

PROJECT_TITLE: Investigating the role of NLGN3 in autism spectrum disorder and sleep disruptions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PHOENIX

ORG_NAME: ENDOTAT BIOTECHNOLOGIES LLC

ORG_STATE: AZ

PHR: PROJECT NARRATIVE This proposal aims to develop a novel, safe, and effective tissue-adhesive tattoo (TAT2) ink for endoscopic marking with improved precision to enhance colorectal lesion surveillance. The current commercial inks pose several limitations including extensive diffusion, fibrosis, and extravasation. The proposed project will develop new, optimized ink formulations with robust stability, biocompatibility, and localization efficacy with evaluation in in vitro cell-based, ex vivo, and in vivo pig studies for pre-clinical evaluation.

PI_NAMEs: REGE, KAUSHAL  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Abdomen;Address;Advisory Committees;Affect;Ambulatory Care;American Cancer Society;Arizona;Atmosphere;Autopsy;Biological Assay;biomaterial compatibility;Biopolymers;Biotechnology;Blood Chemical Analysis;Cancer Etiology;Carbon;Cell Survival;Cells;Cessation of life;Charge;Chitosan;Clinic;Clinical;clinical practice;Colon;Colonoscopy;Colorectal;Colorectal Cancer;commercialization;Contrast Media;Darkness;Detection;Development;Dextrans;Diagnosis;Diffusion;Digestive System Disorders;Disease;Early Diagnosis;Early identification;Emergency department visit;Encapsulated;Endoscopes;Endoscopy;Evaluation;Excision;Extravasation;Family suidae;FDA approved;Fibrosis;follow-up;Formulation;Foundations;gastrointestinal;Gastrointestinal Endoscopy;Gastrointestinal Polyp;Generations;Goals;Histologic;Histology;Hospitals;Human;Implant;implantation;improved;In Vitro;in vitro Assay;in vivo;Inbred BALB C Mice;Inflammation;Inflammatory;Inflammatory Response;Injectable;Injections;Ink;Intestines;iron oxide;Kidney;Laparoscopic Surgical Procedures;Lead;lead candidate;Lesion;Libraries;Life;Light;Lighting;Liver;Location;Lung;Measures;Medical Technology;member;Mucous Membrane;Mus;next generation;novel;Operative Surgical Procedures;Organ;Parents;particle;Particle Size;Patient Care;Performance;Peritoneal;Peritonitis;Persons;Phase;Polyps;Population;porcine model;Pre-Clinical Model;preclinical evaluation;preclinical study;Procedures;Property;Provider;Recommendation;Research;response;scale up;Side;Small Business Technology Transfer Research;Societies;Specimen;Spleen;Spottings;Standardization;statistics;subcutaneous;Submucosa;success;Surface;Suspensions;systemic inflammatory response;systemic toxicity;Tattooing;Techniques;Temperature;Testing;Therapeutic Equivalency;Tissue Adhesives;Tissues;Toxic effect;United States;Universities;Viscosity;Visit

PROJECT_TITLE: Next-generation Tissue-Adhesive Endoscopic Tattoo Ink

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-F (10)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Mental Health;Pediatric;Physical Activity;Prevention;Sleep Research;Substance Misuse;Underage Drinking

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Binge drinking (BD) has numerous adverse consequences, including accidents, assault, and alcohol poisoning. College represents a critical time for the development of BD, wherein drinking patterns established early in the first semester influence future BD and increase risk for alcohol use disorders in the years following graduation. This study will use smartwatches to examine sleep, physical activity, and heart rate variability as prospective predictors of BD onset and frequency during the first and second semesters of college, serving to identify novel biopsychosocial risk factors that will facilitate the early detection and prevention of harmful alcohol use.

PI_NAMEs: HIMELEIN-WACHOWIAK, MCKENZIE  (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Accidents;Acute;Adult;adverse outcome;aged;Alcohol consumption;alcohol poisoning;alcohol prevention;alcohol related problem;alcohol risk;alcohol use disorder;Alcohols;American;assault;Back;binge drinking;Biological Markers;biopsychosocial;Blood alcohol level measurement;cardiovascular health;Cessation of life;Clinical;cohort;Collaborations;college;Consumption;critical period;Data;Detection;Development;drinking;drinking onset;Early Diagnosis;fitbit;follow up assessment;follow-up;Frequencies;Future;General Population;Glucuronides;Health;Health behavior;Heart;heart rate variability;Heavy Drinking;high risk;high risk drinking;Impairment;in vivo;interest;Intervention;Interview;Jet Lag Syndrome;Laboratories;Measurement;Measures;Medical Research;men;Mental disorders;Mentorship;Methodology;Modeling;Monitor;Mood Disorders;National Institute on Alcohol Abuse and Alcoholism;negative affect;novel;Onset of illness;Participant;Patient Self-Report;Pattern;perceived stress;Periodicals;Persons;Physical activity;physical assault;Physiological;Predisposition;preference;Prevalence;Prevention;problem drinker;Procedures;prospective;Prospective Studies;psychologic;Psychology;Psychophysiology;Recording of previous events;recruit;Recurrence;Reporting;Research;Research Personnel;Risk;Risk Factors;Role;Sampling;screening;sexual assault;skills;Sleep;smart watch;social;stem;student participation;substance use;Substance Use Disorder;Surveys;Technology;Time;timeline;tool;Training;university student;Urine;Validation;Woman;Work

PROJECT_TITLE: Smartwatch-based predictors of binge drinking onset in first-year college students: A prospective study


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Work is a social determinant of health, and workers in the United States increasingly engage in non-standard work arrangements that may be classified as forms of emergent work. To better understand emergent work’s implications for worker health and well-being, this project will investigate how these non-standard work arrangements can be classified into distinct forms of emergent work and the lived experiences of emergent work relative to health, well-being, and health disparities. This project will enhance understanding of objective and subjective factors influencing the health and well-being of contemporary workers.

PI_NAMEs: WALSH, RYAN JAMES (contact)

PROGRAM_OFFICER_NAME: GARRIDO, CARLOS OSWALDO

PROJECT_TERMS: Acceleration;Address;Adult;aged;American;Applied Skills;Binding;burden of chronic illness;California;career;Characteristics;Classification;Communities;comparative;Complement;Complex;Consensus;Contracts;Data;Data Science;Data Set;Demographic Factors;demographics;Development;Employment;Equipment and supply inventories;experience;follow-up;Foundations;Future;Growth;Health;Health Disparities Research;health disparity;Health Promotion;Health Surveys;improved;Individual;Influentials;insight;Instruction;interest;Intervention;Investigation;Labor Forces;Learning;Life;Link;Lived experience;Logistic Regressions;Marketing;Mentors;Mentorship;Methods;Minority;Minority Groups;National Institute on Minority Health and Health Disparities;novel;nutrition;Occupational;Occupational Therapist;Occupational Therapy;Occupations;pandemic disease;Participant;Personal Satisfaction;Persons;phenomenological models;Physical activity;Population;population health;Postdoctoral Fellow;Productivity;professional atmosphere;programs;prospective;Qualitative Methods;Research;Research Methodology;Research Project Grants;Risk;Role;Science;Scientist;skills;Sleep disturbances;social determinants;social health determinants;Statistical Data Interpretation;Stress;Surveys;Training;Training Programs;trend;Uncertainty;Unemployment;United States;Universities;Work;Workplace

PROJECT_TITLE: Understanding Social Determinants of Health and Health Disparities in Emerging Work Contexts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Data Science;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Rare Diseases;Sepsis;Social Determinants of Health;Tuberculosis

PHR: Project Narrative Despite recent progress in artificial intelligence (AI) and machine learning (ML), deep learning models have been shown to perform inaccurately on patients from minority racial and ethnic backgrounds. This limitation adversely impacts underrepresented patients through propagating existing biases and inequities in healthcare. The pro- posed research identifies and validates computational strategies to address this issue in the diagnosis and treat- ment of pulmonary tuberculosis, sepsis, and other diseases of important significance to public health.

PI_NAMEs: YAO, MICHAEL STEVEN YU-SHUAN (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: acute care;Address;algorithmic bias;Algorithms;Architecture;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Black Box;Calibration;Classification;Clinical;clinical application;clinical care;clinical decision support;clinical decision-making;clinical diagnosis;Clinical Management;Clinical Medicine;clinical training;Clinical/Radiologic;clinically relevant;Communicable Diseases;Complex;Computational algorithm;Computational Technique;computer science;Computer-Assisted Diagnosis;Computing Methodologies;Critical Illness;Data;Data Set;deep learning;deep learning model;design;Detection;Diagnosis;Diagnostic;diagnostic accuracy;Disease;Disease Management;Disparity population;Engineering;Equitable healthcare;Equity;Ethnic Origin;Evaluation;experimental study;explainable machine learning;Foundations;Future;Graduate Education;health care delivery;health inequalities;Healthcare;Image;image processing;Improve Access;improved;Individual;Inequity;Information Sciences;innovation;insight;Knowledge;Language;Learning;learning network;Machine Learning;machine learning algorithm;machine learning model;marginalization;Measures;Medical;Medical Imaging;Methods;Minority;minority healthcare;Minority Participation;minority patient;Modeling;Modernization;Morbidity - disease rate;mortality;neural network;novel;Patient Care;patient population;patient subsets;Patient-Focused Outcomes;Patients;Performance;Physicians;Population;predictive modeling;professor;Psychological reinforcement;Public Health;Pulmonary Tuberculosis;racial diversity;racial minority;radiologist;Radiology Specialty;Research;Research Personnel;Resource-limited setting;Resources;Robotics;Scientist;Sepsis;septic patients;Series;success;support tools;System;Technical Expertise;Testing;Text;tool;Training;Training and Education;training data;treatment strategy;trustworthiness;Uncertainty;United States Food and Drug Administration;Validation;Vision;Work

PROJECT_TITLE: Trustworthy Machine Learning for Equitable Healthcare

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_NAME: UNIVERSITY OF WASHINGTON

PI_NAMEs: PSATY, BRUCE  (contact)

PROJECT_TERMS: Address;adjudication;African American;Ancillary Study;Applications Grants;biobank;Biological Specimen Banks;Budgets;cardiovascular health;Cardiovascular system;Cephalic;Clinic;cohort;Cohort Studies;Contracts;Coronary heart disease;Data;Data Analyses;Data Collection;data management;Databases;Development;Echocardiography;Elderly;Event;follow-up;Funding;Grant;Heart Diseases;Home visitation;Hospitalization;human old age (65+);Infrastructure;innovation;Magnetic Resonance Imaging;men;Mentors;Methods;mortality;National Heart, Lung, and Blood Institute;older adult;operation;Outcome;Participant;population based;Population Heterogeneity;Process;Productivity;prospective;pulmonary function;Questionnaires;recruit;Research Personnel;Resources;response;Risk Factors;Sampling;Specimen;Stroke;Telephone;U-Series Cooperative Agreements;ultrasound;Woman;working group;Writing

PROJECT_TITLE: CARDIOVASCULAR HEALTH STUDY (CHS)- CORE STUDY OPERATIONS


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PI_NAMEs: GARCIA-SASTRE, ADOLFO  (contact)

PROJECT_TERMS: Animals;Basic Science;Cohort Studies;cross immunity;Development;Disease Outcome;Environmental Risk Factor;Evolution;Human;Immune;Immune response;Immunologic Factors;improved;Influenza;influenza infection;Influenza vaccination;influenzavirus;Molecular;National Institute of Allergy and Infectious Disease;Pathogenicity;Research;response;Sampling;transmission process;Vaccination

PROJECT_TITLE: NIAID Centers of Excellence for Influenza Research and Response


PROJECT_TERMS: Animals;Basic Science;Cohort Studies;cross immunity;Development;Disease Outcome;Environmental Risk Factor;Evolution;Human;Immune;Immune response;Immunologic Factors;improved;Influenza;influenza infection;Influenza vaccination;influenzavirus;Molecular;National Institute of Allergy and Infectious Disease;Pathogenicity;Research;Research Activity;response;Sampling;transmission process;universal influenza vaccine;Vaccination

PROJECT_TITLE: NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Animals;Basic Science;Cohort Studies;Coronavirus;cross immunity;Disease Outcome;Environmental Risk Factor;Evolution;Human;Immune;Immune response;Immunologic Factors;improved;Infection;Molecular;Pathogenicity;Research Activity;respiratory virus;response;Sampling;therapeutic development;Therapeutic Research;transmission process;Vaccination;Vaccine Research;Virus

PROJECT_TITLE: CEIRR: SARS-CoV-2 Research Activities


ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PI_NAMEs: TOMPKINS, S. MARK  (contact)


FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

PROJECT_TERMS: Communication;Contractor;Contracts;data management;data sharing;Development;National Human Genome Research Institute;Policies;Process;Resources;Services;United States National Institutes of Health;Work

PROJECT_TITLE: Data Management and Sharing Policy Support Services (DMSPSS) with Dept of Interior


NIH_SPENDING_CATS: Biomedical Imaging;Cancer

ORG_CITY: KANSAS CITY

ORG_NAME: MIDWEST RESEARCH INSTITUTE

PI_NAMEs: WHITE, PHD, JONATHAN  (contact)

PROJECT_TERMS: Academia;Biological Markers;cancer imaging;cancer therapy;Clinical Trials;Diagnosis;Division of Cancer Treatment and Diagnosis;Dosage Forms;drug discovery;Evaluation;Funding;image guided;image guided therapy;Imaging Techniques;Industry;Life;member;National Cancer Institute;novel diagnostics;novel therapeutics;Play;Retinoblastoma Protein;Role;Running;Support Contracts;Therapeutic


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;Genetics;Human Genome

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative The purpose of this project is to provide efficient and effective implementation of the chosen pragmatic clinical trials and coordination of the IGNITE Network and to facilitate dissemination and communication with relevant communities outside the network. The success of this proposal will help facilitate knowledge translation from the genomic demonstration projects into the research and clinical communities thereby accelerating the translation of proven tools into real world settings.

PI_NAMEs: CHAKRABORTY, HRISHIKESH ;WYATT, CHRISTINA M (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Acceleration;Accountability;Address;Administrative Coordination;Amplifiers;Area;Case Report Form;catalyst;Clinical;clinical care;Clinical effectiveness;clinical practice;Clinical Research;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Clinical Trials Network;ClinVar;Collaborations;Communication;Communities;Community Medicine;Consent;cost effective;Cost Effectiveness Analysis;Creativeness;dashboard;Data;Data Analyses;Data Collection;data interoperability;data management;Data Management Resources;data platform;data quality;Data Sources;data standards;database of Genotypes and Phenotypes;Databases;design;Discipline;Documentation;effective intervention;Effectiveness;electronic data capture system;Enrollment;Ensure;Environment;evidence base;experience;falls;flexibility;Fostering;genome sciences;genomic data;Genomic medicine;Genomics;Goals;implementation evaluation;implementation facilitation;implementation/effectiveness;improved;Information Technology;Infrastructure;innovation;insight;Institution;Institutional Review Boards;International;Intervention;Intranet;Knowledge;knowledge base;knowledge hub;knowledge translation;Leadership;leadership development;Learning;material transfer agreement;Measures;meetings;member;Monitor;novel;Office of Administrative Management;Online Systems;Ownership;Participant;Patient Recruitments;phenotypic data;Positioning Attribute;Pragmatic clinical trial;pragmatic implementation;precision medicine;Problem Solving;Productivity;programs;Protocols documentation;Publications;quality assurance;Quality Control;recruit;Reporting;Research;Research Institute;Resources;Risk;Sample Size;Standardization;Statistical Data Interpretation;Structure;success;synergism;Time;tool;Training;translational genomics;Translations;trial design;United States National Institutes of Health;Universities;uptake;Vision;Work;working group;Writing

PROJECT_TITLE: The IGNITE II CC:  Engagement, Coordination, Demonstration, and Dissemination