NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: PHARMACOLOGY

ORG_NAME: BROWN UNIVERSITY

PHR: Project Narrative Neuronal deposits or inclusions of the essential human protein TDP-43 are a key feature in many patients suffering from Alzheimer’s disease related dementias including frontotemporal dementia and limbic-predominant age-related TDP-43 encephalopathy, and the motor neuron disease amyotrophic lateral sclerosis. Importantly, small chemical changes in TDP-43, including those caused by TDP-43 gene mutations and intracellular modifications, are associated with disease. Therefore, visualizing the structural details of the TDP-43 along its lifecycle with atom-by-atom chemical resolution is an important step to finding new treatments for incurable neurodegenerative diseases of aging.

PI_NAMEs: FAWZI, NICOLAS LUX (contact);MITTAL, JEETAIN

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Age;aging related disease;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Binding;Binding Sites;Biochemical;Biological Assay;biophysical techniques;Biophysics;C-terminal;Cell Aggregation;Cell model;Cell Nucleus;Cell Physiology;Cells;Cellular biology;Characteristics;Chemicals;Collaborations;Complex;Cyclophilin A;Cytoplasmic Granules;Data;Dementia;Deposition;design;Dimerization;Disease;disease model;effective therapy;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Future;Gene Mutation;Goals;Homeostasis;Human;Hydrogen Bonding;Hydrophobicity;Importins;Inclusion Bodies;insight;Life Cycle Stages;limbic-predominant age-related TDP-43 encephalopathy;Link;Liquid substance;Macromolecular Complexes;Maps;Mediating;Missense Mutation;Modification;Molecular;Molecular Biology;molecular modeling;Molecular Probes;Motor Neuron Disease;Mutation;N-terminal;Nerve Degeneration;Neurodegenerative Disorders;Neurons;NMR Spectroscopy;novel;novel therapeutics;Nuclear Import;Nuclear Localization Signal;Pathogenicity;Pathologic;Pathology;Phase;Physiological;Poly Adenosine Diphosphate Ribose;Post-Translational Protein Processing;prevent;Process;protein aggregation;protein TDP-43;Proteins;Research;Research Personnel;Resolution;RNA Binding;RNA Processing;RNA Splicing;Role;simulation;structural biology;Structure;TDP-43 aggregation;Techniques;Testing;therapeutic development;therapeutic target;tool;Variant;Visualization

PROJECT_TITLE: Functional and Pathological Interactions of TDP-43

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Maternal Health;Maternal Morbidity and Mortality;Mental Health;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project seeks to better understand the parenting needs and challenges of women with OUD and their desired outcomes of parenting interventions, then use this information to adapt the Family Check-Up so it is a feasible and appealing prenatal parenting intervention for this population during the prenatal period. Ultimately, this research will inform the design and delivery of more effective and comprehensive parenting support for women with OUD across the perinatal period.

PI_NAMEs: GUYON-HARRIS, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: Address;Affect;Age;Anxiety;Birth;caregiver functioning;Caregivers;caregiving;checkup examination;Child;Child Rearing;Child Welfare;Clinical;Clinical Research;Clinical Trials;community partners;Complex;Data;Dedications;design;Development;Discipline of obstetrics;Drug usage;Ensure;evidence base;Evidence based intervention;experience;Family;family support;feasibility testing;feeding;flexibility;Fostering;Goals;Gynecologist;Health Personnel;improved;infancy;Infant Care;Interpersonal Relations;Intervention;Interview;Knowledge;Learning;Link;Mental Depression;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modeling;Modification;Mothers;Motivation;motivational enhancement therapy;opioid use;opioid use disorder;Outcome;Parent-Child Relations;Parenting Education;parenting intervention;Parents;Participant;Pediatrics;Perinatal;perinatal mental health;perinatal period;Pilot Projects;pilot test;Population;Population Intervention;Positioning Attribute;postnatal;Postpartum Period;Pregnancy;Pregnant Women;prenatal;prenatal intervention;prevent;Prevention;Preventive;preventive intervention;Preventive service;Primary Care;primary care setting;programs;Psychologist;Psychology;psychosocial;Qualitative Research;Recording of previous events;Recovery;recruit;Research;Research Methodology;Research Personnel;Science;Second Pregnancy Trimester;Self Efficacy;Site;skills;Social support;Stress;substance use;substance use treatment;Symptoms;Testing;Thinking;Third Pregnancy Trimester;Training;Trauma;treatment services;Trust;Woman;Women's Health;women's outcomes;Work

PROJECT_TITLE: Promoting positive parenting among pregnant women with opioid use disorder

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Chronic Pain;Dental, Oral, and Craniofacial Disease;Neurosciences;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative Chronic orofacial muscle pain arising from the muscles of mastication (chewing) is a top cause of disability that affects necessary daily activities such as biting, chewing, swallowing, and speaking but also common social activities many people may take for granted such as smiling, laughing, and kissing. Treatment options are currently limited, often inadequate, and can result in substance abuse disorders. The results from my proposed work will elucidate mechanisms underlying the development of muscle pain and positively contribute to strategies for treating this common and debilitating chronic orofacial muscle pain.

PI_NAMEs: LINDQUIST, KAREN ANN (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acceleration;Affect;Afferent Neurons;Anatomy;base;Basic Science;Behavioral Assay;behavioral phenotyping;Bite;Bite Force;burden of illness;candidate marker;Cardiovascular system;career;Cells;Cessation of life;Characteristics;Chronic;chronic pain;Clinical;clinically relevant;collagenase;Complex;Data;defined contribution;Deglutition;designer receptors exclusively activated by designer drugs;Development;Devices;disability;Disease;Electrophysiology (science);Epidemic;Fiber;Foundations;Functional disorder;Gene Expression Profile;Genetic;genetic signature;Goals;Grant;Health;Hypersensitivity;in vivo imaging;Injury;Investigation;Kidney;Knowledge;Learning;Machine Learning;Masseter Muscle;Mastication;Masticatory muscles;masticatory myalgia;Measures;mechanical stimulus;Mechanics;Mechanoreceptors;Mediating;Modality;Modeling;mouse model;multidisciplinary;Mus;Muscle Development;muscular structure;Musculoskeletal Pain;Myalgia;Neurites;Neuroglia;Neurologic;Neuronal Plasticity;Neurons;novel therapeutic intervention;Opioid;opioid overuse;orofacial;Orofacial Pain;Overdose;Pain;Pain management;pain relief;patch clamp;Peripheral;Persons;Piezo 2 ion channel;prevent;Prevention;Primates;Property;Published Comment;receptor;Regulation;Research;response;Risk Factors;Role;Scientist;single cell analysis;single cell sequencing;single-cell RNA sequencing;Smiling;social;Substance abuse problem;Temporomandibular Joint Disorders;Testing;therapeutic target;Time;Training;Transgenic Mice;Translational Research;Trigeminal System;Work

PROJECT_TITLE: Regulation of masticatory myalgia development by distinct trigeminal neuron subtypes innervating masseter muscle

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BURLINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE The molecular motors dynein and kinesin move membrane-bound vesicles, organelles, and mRNA on microtubules, a process required for cell polarity and function and axonal transport. Defects in trafficking contribute to developmental and neurodegenerative diseases, and we will investigate molecular mechanisms that regulate cargo motion using an in vitro reconstitution approach. Cytokinesis, the fundamental process by which a cell divides into two daughters following mitosis, is key to transmitting genetic material between generations, and its failure can induce changes in ploidy resulting in oncogenesis or cell death. We will characterize the biophysical properties of the myosin motors that drive this process in fission yeast, a widely used model system that has provided the most advanced models of the cytokinetic contractile ring.

PI_NAMEs: TRYBUS, KATHLEEN M (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Adaptor Signaling Protein;Affect;Amyotrophic Lateral Sclerosis;Animals;anterograde transport;Axonal Transport;Binding;Binding Proteins;Biochemical;Biological;Biological Models;Biological Process;biophysical properties;biophysical techniques;Biophysics;Cell Death;Cell Physiology;Cell Polarity;cell type;Cells;Collaborations;Complex;constriction;Coupling;Cytokinesis;Cytoplasm;Data;Daughter;Defect;Dependence;developmental disease;driving force;dynactin;Dynein ATPase;Failure;Fission Yeast;Generations;Genetic Materials;Geometry;Goals;Huntington Disease;Huntington gene;In Vitro;insight;Kinesin;Light;Liposomes;Membrane;Messenger RNA;Microscopy;Microtubule-Associated Proteins;Microtubules;Mitosis;Modeling;Molecular;Molecular Motors;Motility;Motion;Motor;Motor Activity;Myosin ATPase;Myosin Type II;Neurodegenerative Disorders;Organelles;Organism;Outcome;Output;Pattern;Phosphorylation;Play;Ploidies;Process;Property;Proteins;reconstitution;retrograde transport;Role;scaffold;Scaffolding Protein;single molecule;Speed;Techniques;trafficking;transmission process;tumorigenesis;Vesicle

PROJECT_TITLE: Molecular Mechanisms of Motility Deduced from in Vitro Reconstituted Microtubule- and Actin-Based Motor Complexes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Public Health Relevance The treatment of psychiatric diseases, including highly intractable clinical conditions such as depression, has been held back by a limited understanding of the underlying principles of healthy brain circuit function. This proposal focuses on the mechanisms and function of neural circuits in the medial entorhinal cortex, a brain region that contains neural circuits highly associated with navigation and memory that can go awry in a range of mood and neural disorders. Understanding how normal medial entorhinal circuits support behavior could lead to new, more precise treatments that reduce the memory-related symptoms of brain disease.

PI_NAMEs: GIOCOMO, LISA  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Address;Animals;Back;Behavior;Behavioral;Behavioral Mechanisms;Brain;Brain Diseases;Brain region;cell cortex;Cells;Clinical;Code;cortex mapping;Cues;Data;Disease;Dorsal;Electrophysiology (science);entorhinal cortex;Environment;Etiology;expectation;experience;experimental study;flexibility;Geometry;Goals;Hippocampus;improved;insight;Learning;Length;Link;Location;Maps;Medial;member;Memory;Mental Depression;Mental disorders;Moods;Mus;network models;neural;neural circuit;Neurodegenerative Disorders;Neurons;Neurophysiology - biologic function;Odors;optogenetics;Population;Population Dynamics;Positioning Attribute;Psychiatric therapeutic procedure;public health relevance;rate of change;recruit;response;Rewards;Rotation;Running;Sampling;Sensory;sensory input;Silicon;spatial memory;Speed;Stimulus;Structure;Symptoms;Testing;Thirst;virtual reality;virtual reality environment;Visual;way finding;Work

PROJECT_TITLE: The Dynamics of Neural Representations for Distinct Spatial Contexts and Memory Episodes

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Diabetes;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: JOSLIN DIABETES CENTER

ORG_STATE: MA

PHR: Project Narrative Cases of pre-diabetes and type 2 diabetes (T2D) in children and adolescents have been rising at alarming rates, which is concerning in light of data showing that T2D in youth is more severe and more likely to cause complications than T2D diagnosed in adulthood. Currently it is difficult to predict whether a child with pre- diabetes will go on to develop T2D. Our proposal aims to discover predictive biomarkers to identify youth at highest risk of progressing from prediabetes to T2D, which ultimately will allow for earlier detection and prevention.

PI_NAMEs: FLEISCHMAN, AMY DEBRA;ISGANAITIS, ELVIRA MARIE (contact);STANLEY, TAKARA LEAH

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: actigraphy;Address;Adolescent;Adrenal Glands;Adult;Affect;Age;Androgens;Area;B-Lymphocytes;Basal metabolic rate;Beta Cell;biobank;Biological;blood glucose regulation;Blood Vessels;Body Composition;Body mass index;Boston;Cell Physiology;Characteristics;Child;Childhood;Clinical;Clinical assessments;clinical center;Clinical Research;cohort;Collaborations;Color;Communities;community setting;Continuous Glucose Monitor;COVID-19 pandemic;Data;Data Collection;data repository;Detection;Development;Diabetes Mellitus;diabetes pathogenesis;Diagnosis;Diet Surveys;Disease;Dual-Energy X-Ray Absorptiometry;Early Diagnosis;Environmental Risk Factor;Epigenetic Process;Evaluation;Evolution;Family history of;fasting plasma glucose;Fatty acid glycerol esters;Feces;fitness;Future;General Hospitals;Genomics;Geography;Glucose;Glycosylated hemoglobin A;Gonadal Hormones;Growth;Hair;Hand Strength;Hepatic;high body mass index;high risk;Home;Hormonal;Hormones;Hyperglycemia;Impairment;Incidence;incretin hormone;indexing;Insulin Resistance;insulin secretion;insulin sensitivity;Insulin-Like Growth Factor I;Light;macrovascular disease;marginalized community;marginalized population;Massachusetts;Measurable;Measures;Mediator;Metabolic;metabolomics;modifiable risk;multiple omics;Neighborhood Health Center;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Oral;Participant;Pathogenesis;Pediatric Hospitals;Peripheral Blood Mononuclear Cell;Phenotype;Physical activity;Physiological;Plasma;Prediabetes syndrome;predictive marker;predictive modeling;prevent;Prevention;progression marker;progression risk;Puberty;Public Health;recruit;remote assessment;repository;Research;Risk;Risk Factors;Risk Reduction;Running;sample collection;Sampling;Shapes;social factors;social health determinants;Somatotropin;Stress;Systems Biology;Techniques;Testing;trend;Triglycerides;type 2 diabetes in children;Ultrasonography;ultrasound;Urine;Visceral fat;VO2max;waist circumference;wearable device;Youth

PROJECT_TITLE: Understanding, Predicting and Preventing Type 2 Diabetes in Youth, Boston Clinical Center (UPP Study)


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: The bacteria that live on the surfaces of the nasal passages affect human health. This research focuses on understanding how benign nasal bacteria interact with each other and with the cells that line the nasal passages to form a stable community, and how this can protect us from colonization by bacteria that can cause infections.

PI_NAMEs: LEMON, KATHERINE PAIGE (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Affect;Age;Air;Area;auxotrophy;Bacteria;Benign;Biochemical Pathway;Biological Models;Biomimetics;Cell Line;Coculture Techniques;Collaborations;Collection;Communities;Corynebacterium;Data;Disease;Environment;Epithelium;Etiology;Food Webs;Funding;Genes;Genetic Engineering;Genomics;Goals;Growth;Health;Health Benefit;Health Promotion;host-microbe interactions;Human;In Vitro;in vivo;Infection;Infection prevention;innovation;Liquid substance;Metabolic;metabolomics;Microbe;microbial;microbial community;Modeling;Molecular;Nasal Epithelium;nasal microbiome;nasal microbiota;National Institute of General Medical Sciences;Nose;novel strategies;Nutrient;Organoids;Otitis Media;pathobiont;Persons;Phenotype;Physiology;Play;Pneumonia;Proteins;Research;Risk;Role;Shapes;Staphylococcus aureus;Streptococcus pneumoniae;Structure;Surface;System;transcriptomics;volunteer

PROJECT_TITLE: Mechanisms of Corynebacterium-Dolosigranulum Interactions that Shape Human Nasal Microbiota

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lymphatic Research;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Recent immunological and physiological studies have provided evidence in support of a central nervous system (CNS) lymphatic drainage system in vertebrate animals, and preliminary evidence has suggested that a similar system exists in humans. If operative, this system may have central relevance to many vascular and fluid clearance disorders such as stroke, multiple sclerosis, Parkinson's disease, and Alzheimer's disease related dementia (ADRD): diseases which represent some of the most pressing healthcare challenges of the 21st century. Evaluating this possibility will require improved, robust imaging methods sensitive to lymphatic drainage dysfunction; as such, the goal of this work is to apply novel magnetic resonance imaging approaches, optimized already for evaluating lymphatic circulation in patients with peripheral lymphatic dysfunction, to quantify relationships between physiological hallmarks of ADRD and CNS lymphatic function in humans.

PI_NAMEs: CLAASSEN, DANIEL OLIVER;DONAHUE, MANUS J (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta accumulation;Address;Adult;Age;age related changes;Aging;alpha synuclein;Alzheimer's disease related dementia;amnestic mild cognitive impairment;Amyloid beta-Protein;Anesthesia procedures;animal data;aquaporin 4;awake;Behavior;Behavioral;biological sex;Blood;Blood Vessels;bone;Brain;Brain imaging;brain parenchyma;Brain region;brain tissue;Central Nervous System;cerebrospinal fluid clearance;Cervical;Cervical lymph node group;Clinical;clinical phenotype;clinically relevant;cognitive impairment in Parkinson's;Communication;Coupling;Data;Deep Brain Stimulation;Disease;Enrollment;Ependymal Cell;Etiology;Foundations;Functional disorder;glymphatic flow;glymphatic function;glymphatic system;Goals;Head and neck structure;Health;Healthcare;healthy aging;hemodynamics;Human;Image;imaging approach;Imaging Device;imaging modality;Immunologics;Impaired cognition;improved;in vivo;insight;Intercellular Fluid;Investigation;Kinetics;Knowledge;life span;Link;Liquid substance;Lymph;lymph flow;Lymph Node Dissections;lymph nodes;Lymphatic;lymphatic circulation;lymphatic drainage;lymphatic dysfunction;Lymphatic function;Lymphatic System;lymphatic vasculature;lymphatic vessel;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Meningeal lymphatic system;Methods;motor symptom;Multiple Sclerosis;Neurobehavioral Manifestations;Neurons;neuropathology;novel;older adult;Parkinson Disease;Participant;Pathologic;Patients;peer;Performance;Perfusion;Peripheral;peripheral blood;Physiological;Physiology;Positron-Emission Tomography;Production;Propofol;protein aggregation;quantitative imaging;Reproducibility;response;Rest;Sedation procedure;sex;Sleep Disorders;Stroke;Structure;Structure of choroid plexus;Subgroup;Symptoms;System;Tissues;Translating;Venous;Vertebrates;Visualization;Wakefulness;Work;β-amyloid burden

PROJECT_TITLE: Quantitative Imaging of Brain Glymphatic Function in Humans

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Aging;Estrogen

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Principal Investigator (Last, First, Middle): Pruitt, Kevin Project Narrative From Alzheimer’s disease to autoimmunity, aberrant steroid hormone production plays a role. During aging, studies have documented aberrant changes in steroidogenesis. Proposed studies will focus on critical unknowns regarding the impact of aging on regulation of aromatase, an enzyme which converts androgens to estrogens.

PI_NAMEs: PRUITT, KEVIN  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: 3-Dimensional;Acetylation;Age;age related;Aging;aging mechanism;aging related;Alzheimer's Disease;Amino Acid Substitution;Anabolism;anastrozole;Androgens;Animal Model;Aromatase;Aromatase Inhibitors;Autoimmune Diseases;Autoimmunity;Automobile Driving;Basic Science;Behavior;Binding;Biology;bone;Brain;cell motility;Cell Proliferation;Cells;Characteristics;Chronic;Clinic;Data;Deacetylation;Development;Dsh protein;enzyme activity;Enzymes;Epithelium;Estradiol;Estrogens;Foundations;Functional disorder;Future;Gene Mutation;Genetic Transcription;GPER gene;Growth;Immune;Immune system;immunoregulation;in vivo;inhibitor therapy;insight;Knowledge;Letrozole;Link;Lysine;Mammary gland;Mammary Gland Parenchyma;Maps;Mouse Mammary Tumor Virus;mouse model;neoplastic;Neuroendocrinology;novel;Organ;Pathologic;Pathology;Pathway interactions;Pattern;Physiology;polyoma middle tumor antigen;Post-Translational Protein Processing;Post-Translational Regulation;Principal Investigator;Production;promoter;Protein Family;Proteins;RAS genes;Regulation;Reporting;Role;Signal Pathway;Signal Transduction;skeletal dysplasia;spheroids;Steroid biosynthesis;steroid hormone;Testing;Tissues;Transgenic Animals;Transgenic Mice;translational barrier;virtual;WNT Signaling Pathway;Woman

PROJECT_TITLE: Post-translational regulation of aromatase in aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Nanotechnology;Women's Health Research

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Project Narrative This project will investigate an integrated computational and experimental approach to provide further understanding into the biological and physical mechanisms involved in a new, viable, highly effective therapeutic solution based on EF2K targeting with miR-22 in triple negative breast cancer treatment. This project attempts to fill a significant need for current clinical practice in pancreatic cancer treatment, and thus is relevant to NIH's mission because it aligns with the NIH's goal to foster innovative research strategies and their applications as a basis for ultimately protecting and improving health.

PI_NAMEs: OZPOLAT, BULENT ;WANG, ZHIHUI  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Accounting;Acute;Antineoplastic Agents;appropriate dose;aptamer;axl receptor tyrosine kinase;Binding;Biological;Biological Markers;Biological Process;Biology;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Treatment;calmodulin-dependent protein kinase III;cancer subtypes;cancer therapy;Cell Communication;Cell Line;Cells;chemotherapeutic agent;chemotherapy;Chronic;Clinical;clinical practice;clinical translation;clinically significant;Complex;Coupling;Data;Databases;Death Rate;Diffusion;dosage;Dose;Doxorubicin;Drug resistance;Drug Transport;experimental study;Feedback;Fostering;Future;Goals;guided inquiry;Health;Immune;improved;In Vitro;in vivo;innovation;Invaded;Investigation;lipid nanoparticle;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;mathematical model;Maximum Tolerated Dose;Mediating;Methodology;microRNA delivery;MicroRNAs;Mission;model development;Modeling;Molecular Target;mouse model;nanoparticle;nanoparticle delivery;nanotherapeutic;nanotherapy;Neoplasm Metastasis;Normal tissue morphology;novel therapeutics;Organ;Patients;Penetration;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;physical process;Physics;Pre-Clinical Model;preclinical development;predictive modeling;Process;Prognosis;receptor;Relapse;Repression;Research;response;Safety;Schedule;Small Interfering RNA;System;targeted delivery;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic miRNA;therapeutic target;therapeutically effective;Time;Toxic effect;Treatment Efficacy;Treatment outcome;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;Tumor stage;tumorigenesis;United States National Institutes of Health;Work

PROJECT_TITLE: Nanoparticle delivery of miRNA-based therapeutics to overcome clinical challenges in triple negative breast cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Cognitive disabilities, such as those observed in developmental disorders like Autism, are often marked by improper synaptic connections between neurons. Although there are clear links between abnormal synaptic development and behavioral deficits persisting into adulthood, the specific cellular and molecular mechanisms that underly these deficits are not well understood. Disbalances of the neuromodulator serotonin have been associated with improper circuit formation in the brain and an increased likelihood of developing cognitive disabilities; characterizing the role of serotonin in proper synaptic development will help further our understanding of the cellular and molecular etiologies of developmental disorders.

PI_NAMEs: OGELMAN, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Acute;Adult;Affect;autism spectrum disorder;Bathing;Behavioral;Brain;Brain Diseases;Brain region;Cerebral cortex;Clinical Research;Cognition Disorders;Cognitive;Cognitive deficits;cognitive disability;cognitive function;Color;Communication;Complex;Data;Decision Making;Dendritic Spines;Denervation;density;design;Development;developmental disease;Disease;Electrophysiology (science);Etiology;Excitatory Synapse;experimental study;fluorescence lifetime imaging;Fluorescence Resonance Energy Transfer;Frequencies;Functional disorder;Glutamates;hippocampal pyramidal neuron;Human;Image;Imaging Techniques;Impairment;Individual;insight;Knowledge;Life;Link;Long-Term Potentiation;Mediating;Molecular;Mus;nerve supply;neural circuit;neurochemistry;Neuromodulator;neuron development;neuronal circuitry;Neurons;Neurotransmitters;novel;optogenetics;Oral Administration;Pathology;pharmacologic;Pharmacology;Play;postnatal development;postnatal period;postsynaptic;Prefrontal Cortex;prenatal;Receptor Activation;Research;Rodent;Role;Selective Serotonin Reuptake Inhibitor;serotonergic regulation;Serotonin;serotonin 7 receptor;Serotonin Receptor 5-HT2A;Signal Transduction;Signaling Molecule;Slice;Social Behavior;survivorship;Synapses;Techniques;Testing;Time;tool;two-photon;Vertebral column

PROJECT_TITLE: Identifying the Role of Serotonergic Signaling in the Maturation ofDendritic Spines


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Pediatric;Social Determinants of Health

ORG_CITY: MILWAUKEE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN MILWAUKEE

ORG_STATE: WI

PHR: This SEPA program will prepare pre-service, early career, and in-service teachers to provide large numbers of students, particularly disadvantaged and underrepresented students, with authentic research experiences linking biological concepts with societally relevant problems of environmental health/chemical toxicity. To become adept at doing and analyzing experiments, students will develop a solid comprehension of the elements of the scientific method and an introductory facility with computational analysis of large data sets. Conducting research within a framework of understanding the history of environmental chemicals and their implications for environmental justice, students will gain insight into relationships between science and society and, in the process, be stimulated to enter biomedical STEM fields.

PI_NAMEs: BERG, CRAIG A.;CARVAN, MICHAEL J;PETERING, DAVID HAROLD (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: Acceleration;Address;Adolescent;Animal Model;Area;Attention;Award;Behavioral Research;Big Data;Biological;Biological Process;Biological Sciences;Biomedical Research;Businesses;career;Certification;chemical safety;Chemicals;Clinical Research;Collaborations;college;Common Good;Communication;Communities;comparative;Complement;Comprehension;Computer Analysis;Data;Data Analyses;data repository;Data Science;data submission;data to knowledge;Decision Making;design;Development;disadvantaged student;Discipline;economic disparity;Education Projects;Educational Activities;Educational process of instructing;Elements;Environment;environmental chemical;Environmental Health;Environmental Impact;environmental justice;Evaluation;experience;experimental study;Funding;Future;Future Teacher;General Population;Goals;Grant;Health Professional;health training;high school;High School Student;Infrastructure;inservice teacher;insight;Institution;interest;K-12 Education;Knowledge;large datasets;Lead Poisoning;Learning;Life Style;Link;literacy;literate;Literature;Low income;Maps;matriculation;member;Methods;Minority;model organism;Modeling;National Institute of General Medical Sciences;Nature;Next Generation Science Standards;novel;online version;Organism;Paper;Pathway interactions;Pheretima sieboldi;Population;posters;Process;Program Development;Program Evaluation;programs;Recording of previous events;Regulation;Research;Research Activity;Running;Rural;Schools;Science;science and society;science education;science teacher;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Scientific Evaluation;Scientist;Services;Societies;Solid;STEM field;student conference;Students;success;symposium;System;teacher;Teacher Professional Development;Toxic effect;Toxicology;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;web site;Wisconsin;Work;Youth;Zebrafish

PROJECT_TITLE: Learning and Discovery in Experimental Environmental Health Science: On the Path from Data to Knowledge

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: OAKLAND

ORG_NAME: PUBLIC HEALTH INSTITUTE

PHR: PROJECT NARRATIVE The Children's Oncology Group (COG) is the world's largest organization devoted exclusively to childhood and adolescent cancer research. Over 220 leading children's hospitals, universities, and cancer centers across US, Canada and other countries participate in COG research, which is focused on developing better treatments that can improve the cure rate and outcome for all children with cancer.

PI_NAMEs: HAWKINS, DOUGLAS S. (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: 1 year old;Acceleration;Acute;Acute Myelocytic Leukemia;Adolescent;anti-cancer research;Australia;Brain Stem Glioma;Canada;Cancer Center;cancer diagnosis;Cancer Patient;cancer therapy;Caring;Cause of Death;Cell Therapy;chemotherapy;Child;Child Support;Childhood;childhood cancer survivor;Childhood Leukemia;Clinical;Clinical Research;clinical translation;Clinical Trials;Clinical Trials Design;Collaborations;Collection;Communities;Complication;Country;design;Development;Diagnosis;Disease;Dose;Eligibility Determination;Enrollment;Ensure;experience;Family;Foundations;Functional disorder;Generations;Goals;health related quality of life;high risk;Hormonal;Immunotherapy;improved;improved outcome;Infrastructure;innovation;Institution;Interdisciplinary Study;Knowledge;Laboratories;Late Effects;Lead;Malignant Childhood Neoplasm;Malignant Neoplasms;member;Methods;Mission;Molecular;Morbidity - disease rate;multidisciplinary;National Cancer Institute;National Clinical Trials Network;Neuroblastoma;New Zealand;novel therapeutic intervention;operation;Organ;organizational structure;Outcome;Patients;Pediatric Hospitals;Pediatric Oncology Group;Pharmaceutical Preparations;Population Heterogeneity;Population Research;Positioning Attribute;Productivity;Prognosis;Quality of life;Rare Diseases;reproductive;Research;Research Personnel;Scientist;Second Primary Cancers;Site;small molecule;success;Survival Rate;Survivors;survivorship;Tissues;Translational Research;translational study;United States;Universities;Work

PROJECT_TITLE: COG NCTN Network Group Operations Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Sedentary behavior serves as the greatest modifiable risk factor causing cognitive decline in both normal aging individuals and those with Alzheimer's Disease in the United States. This proposal will investigate the hypothesis that specific patterns of exercise engage a molecular feedback loop that integrates rate-limiting aspects of acetyl-CoA metabolic pathways and histone acetylation/methylation mechanisms to modulate gene expression required for long-term memory formation and synaptic plasticity. Furthermore, we identify a pharmacological approach that ameliorates deficits in acetyl-CoA mechanisms in the aging brain, improves synaptic plasticity and memory, and may provide novel insight into therapeutic design.

PI_NAMEs: WOOD, MARCELO ANDRES (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Acceleration;Acetyl Coenzyme A;Acetyl-CoA Carboxylase;Acetylation;Adult;Affect;Age;age related;Aging;aging brain;aging hippocampus;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease risk;ATAC-seq;Behavior;Brain;brain health;Brain-Derived Neurotrophic Factor;Cell Culture Techniques;Cell Nucleus;Cell Physiology;Censuses;Chromatin;Cognition;Cognitive;Data;Dementia;design;Enzymes;Epigenetic Process;epigenetic regulation;epigenome;Equilibrium;Exercise;experience;Feedback;Female;Frequencies;Future;Gene Expression;Gene Expression Regulation;gene repression;Goals;Health;Hippocampus;Histone Acetylation;Histone H3;histone modification;human old age (65+);Impaired cognition;Impairment;improved;Individual;insight;Intervention;Learning;life span;long term memory;Long-Term Potentiation;Lysine;male;Measures;Mediating;Memory;memory consolidation;memory process;Metabolic;Metabolic Pathway;Metabolism;Methylation;Modeling;modifiable risk;Modification;Molecular;mouse model;Mus;Neurons;normal aging;novel;novel strategies;Pathway interactions;Pattern;pharmacologic;Population;prevent;Regulation;Reporting;Research;Risk Factors;sedentary lifestyle;sex;Signal Transduction;spatial memory;Synaptic plasticity;Synaptic Transmission;Therapeutic;therapeutic development;Time;transcriptome sequencing;United States;Update;Wild Type Mouse;Woman;Work

PROJECT_TITLE: Investigating the interface of epigenetics and metabolism underlying memory formation in the adult, aging, and AD brain


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Digestive Diseases;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Neuroblastoma;Neurosciences;Orphan Drug;Pancreatic Cancer;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Cellular therapy has made a dramatic impact on the treatment of B cell lymphoma and leukemia. However, attempts to apply cellular therapy to solid tumors have largely been unsuccessful. This project seeks to both develop and apply next-generation synthetic biology tools to tackle the twin challenges of safely targeting and improving the efficacy of therapeutic cells for solid tumors.

PI_NAMEs: ALLEN, GREG MANESS (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: antigen detection;Antigen Targeting;Antigens;B lymphoid malignancy;B-Cell Lymphomas;Bioinformatics;Biometry;California;cancer immunotherapy;career development;Cell Therapy;cell type;Cells;cellular engineering;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical practice;Clinical Trials Design;combinatorial;Comprehensive Cancer Center;Cross Reactions;cross reactivity;cytokine;Cytotoxic T-Lymphocytes;Data Collection;Dedications;Department chair;design;Detection;Disease;Doctor of Philosophy;early phase clinical trial;early phase trial;Ecosystem;effective therapy;engineered T cells;Engineering;Environment;experience;Faculty;Fibroblasts;Foundations;gene repression;Generations;Genetic Engineering;Goals;Immune system;Immunocompetent;Immunotherapy;improved;Knowledge;Laboratories;Lead;leukemia/lymphoma;Logic;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Medical Oncologist;Medical Oncology;Mentors;Mentorship;mesothelin;Molecular;mouse model;Mus;neoplastic cell;Neuroblastoma;Neurons;neurotoxicity;next generation;Normal Cell;Normal tissue morphology;novel;novel therapeutics;Organ;Pancreatic Adenocarcinoma;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;Patients;Pharmacology;Physicians;Positioning Attribute;Postdoctoral Fellow;prevent;Production;professor;programs;Proteins;receptor;receptor expression;Research;Research Personnel;Safety;San Francisco;Scientist;Signal Transduction;Solid;Solid Neoplasm;success;Surface Antigens;synthetic biology;Synthetic immunology;System;Testing;Therapeutic;tool;Toxic effect;Training;translational immunology;translational research program;Translations;Treatment Efficacy;tumor;Tumor Antigens;tumor immunology;tumor microenvironment;Tumor Tissue;Twin Multiple Birth;Universities;Work

PROJECT_TITLE: Developing novel CAR T cell designs using combinatorial antigen detection

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PUBLIC HEALTH STATEMENT This study will use a community-engaged approach to identify an effective, culturally relevant, and sustainable strategy for identifying high-risk Black families from an underserved population, facilitating genetic testing, and expanding opportunities for personalized cancer treatment, prevention, and screening. This approach may be of particular benefit to hundreds of thousands Black patients and their relatives because they are often unaware of their risks, less likely to have a provider discuss their risk and refer them for GT at the time of diagnosis and are not equably garnering the potentially lifesaving benefits of personalized care.

PI_NAMEs: KINNEY, ANITA Y. (contact);SCHWARTZ, MARC D

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: 2 arm randomized control trial;access disparities;Address;Advanced Malignant Neoplasm;Advocate;arm;Arousal;Awareness;black patient;Black Populations;Black race;cancer genomics;cancer health disparity;Cancer health equity;Cancer Patient;Cancer Survivor;cancer therapy;care delivery;Caring;cascade genetic testing;chatbot;Chronic;Clinical;Clinical Oncology;clinical practice;Communication;Communities;community engaged approach;community engagement;comparative efficacy;Complex;Conflict (Psychology);cost;Counseling;Data;Decision Making;Development;Diagnosis;digital intervention;Disease;disease-causing mutation;Disparity;disparity reduction;Distress;Education;Effectiveness;empowerment;Enrollment;Equity;Ethnic Population;experience;Family;Family member;Fright;Genetic;Genetic Counseling;genetic counselor;genetic testing;Genome;Genomics;Germ Lines;Goals;Guidelines;Health behavior;health care delivery;Health Insurance Portability and Accountability Act;Health Services;Healthcare Systems;Hereditary Malignant Neoplasm;Hereditary Neoplastic Syndromes;high risk;High-Risk Cancer;implicit bias;Improve Access;Individual;individualized prevention;Inequity;innovation;Knowledge;Laboratories;Letters;Life;low socioeconomic status;Malignant Neoplasms;Mediating;Mediator;Medical;meetings;Methodology;Modeling;mortality;Motivation;Not Hispanic or Latino;Oncology;optimism;Outcome;Participant;Pathogenicity;Patients;Perception;personalized cancer therapy;personalized care;Physicians;Policies;Population;Prevention;Primary Prevention;Provider;psychosocial;psychosocial outcome;Public Health;racial disparity;racial minority;racial population;Randomized;Regrets;Resources;response;Risk;satisfaction;screening;Second Primary Cancers;Secondary Cancer Prevention;Secondary Prevention;Service delivery model;Services;social culture;Survivors;System;Testing;testing uptake;therapy resistant;Time;treatment as usual;underserved minority;Underserved Population;usual care arm;Variant;Work

PROJECT_TITLE: Addressing Genomic Disparities in Cancer Survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-G(90)S]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The SARS-CoV-2 nucleocapsid (N) protein is an abundant RNA binding protein that plays a variety of roles in the viral life cycle, notably in the packaging of genomic RNA during virion assembly. Despite the critical role N protein plays in genome packaging, the molecular details that underlie this process are poorly understood. Here we combine single-molecule fluorescence and force spectroscopy with ensemble biophysical experiments and simulations to uncover the molecular details that underlie how N protein mediates genome condensation.

PI_NAMEs: SORANNO, ANDREA  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Acute;Address;Affinity;Anti-viral Agents;Attenuated;Behavior;betacoronavirus;Binding;Biological Assay;Biophysics;Cells;Clinical;Coronavirus;coronavirus pandemic;coronavirus therapeutics;Coupled;COVID-19 pandemic;Data;design;Development;Diameter;Disease;Dissection;Distant;Encapsulated;experimental study;Family;Fluorescence;Fluorescence Spectroscopy;Future;Genome;genomic RNA;Goals;high throughput screening;Human;In Vitro;insight;Investigation;Knowledge;Lead;Length;Life;Life Cycle Stages;Liquid substance;Measurement;Measures;Mediating;Methods;Microscope;Microscopy;Middle East Respiratory Syndrome;Molecular;N Domain;novel;novel strategies;Nucleic Acids;Nucleocapsid;optic trap;optical traps;Phase;Physical condensation;Play;prevent;Process;Proteins;Public Health;Publishing;Resolution;RNA;RNA Binding;RNA Viruses;RNA-Binding Proteins;RNA-Protein Interaction;Role;SARS-CoV-2 genome;screening;Severe Acute Respiratory Syndrome;simulation;single molecule;Site;small molecule;Specificity;Spectrum Analysis;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic;Therapeutic Intervention;Vaccines;Viral;Viral Genome;Viral Packaging;Virion;Virus;Virus Replication;Work;zoonotic coronavirus

PROJECT_TITLE: A multipronged investigation of SARS-CoV-2 genome packaging

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Immunotherapy;Pediatric;Pediatric Cancer;Rare Diseases

PHR: This work aims to better understand the pediatric cancer Ewing sarcoma, specifically investigating the immunobiology in the setting of tumor DNA damage. The studies will be performed by examining the cancer cells themselves as well as by examining the immune cells in proximity to the tumor that can influence growth and spread of the cancer. This career development grant will provide the applicant with training in tumor immunology and bioinformatic analyses, an area of growing importance in pediatric oncology.

PI_NAMEs: BAILEY, KELLY  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Activated Lymphocyte;Address;Adolescent;Advanced Malignant Neoplasm;Agonist;Animal Model;anti-cancer research;anti-tumor immune response;Antineoplastic Protocols;Antitumor Response;Area;Authorship;Automobile Driving;BARD1 gene;Bioinformatics;BRCA1 gene;Cancer Biology;cancer cell;career;career development;CD8-Positive T-Lymphocytes;Cell model;Cell Surface Proteins;Cells;Cellular biology;checkpoint inhibition;checkpoint therapy;Childhood Cancer Treatment;Chimeric Proteins;Coculture Techniques;Combination immunotherapy;Combined Modality Therapy;Committee Members;Complement;Computer Analysis;Cyclic GMP;cytokine;cytotoxic CD8 T cells;Data;Dedications;Defect;Development Plans;Diagnosis;DNA;DNA Damage;DNA Repair;Doxorubicin;Educational Status;Educational workshop;efficacy evaluation;Environment;Ewings sarcoma;EWS-FLI1 fusion protein;Feedback;Fostering;Gene Activation;gene repair;Germ Lines;Germ-Line Mutation;Goals;Grant;Growth;homologous recombination;Human;humanized mouse;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immunobiology;immunogenicity;Immunology;immunoregulation;Immunotherapy;Impairment;improved;In Vitro;in vivo;Individual;Infiltration;Inflammatory;Interferon Activation;Investigation;Investments;IRF1 gene;K-Series Research Career Programs;Knowledge;Laboratories;Literature;Location;Malignant Bone Neoplasm;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuscripts;Mediating;meetings;Mentors;mouse model;Mutation;neoplastic cell;novel therapeutic intervention;Oncogenic;Pathway interactions;patient subsets;Patients;Pediatric Oncologist;Pediatric Oncology;Physicians;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;pre-clinical;programmed cell death ligand 1;programs;Radiation;recruit;Regulation;Relapse;repair function;Research;response;Sampling;Science;Scientist;Seasons;Signal Transduction;skills;Specimen;Stimulator of Interferon Genes;T cell infiltration;T cell response;T-Lymphocyte;Technical Expertise;Techniques;Testing;Training;Training Technics;tumor;Tumor Cell Biology;tumor DNA;tumor immunology;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Universities;Up-Regulation;Vocational Guidance;Woman;Work

PROJECT_TITLE: DNA Damage and Immunogenicity in Ewing Sarcoma


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PHR: NARRATIVE Menopause is accompanied by extensive hormonal and physiological changes that can negatively affect women’s health and increase women’s risk of cardiovascular disease, though the molecular mechanisms are poorly understood. Here we propose to identify gene expression differences between premenopausal and postmenopausal women’s tissues, enabling detection of molecular pathways impacted by menopause. These findings could provide candidate mechanisms for the increased disease burden experienced by women post- menopause and could inform the future development of improved therapeutics for cardiovascular health.

PI_NAMEs: THEUSCH, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: HONG, YULING

PROJECT_TERMS: Adipose tissue;Adult;Affect;Age;age effect;Aging;aging gene;aging process;Biology;Blood Pressure;Blood Vessels;bone;Breast;burden of illness;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cell type;Chronology;Classification;Coronary heart disease;Data;Data Set;Detection;Development;differential expression;dimension reduction;disorder risk;Endocrine;Estrogens;Evaluation;experience;Female;female sex hormone;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene interaction;Genes;Genetic Transcription;Genotype;Gonadal Steroid Hormones;Health;heart disease risk;Hormonal;Hormonal Change;hormone therapy;Human;human tissue;improved;Individual;innovation;insight;Knowledge;Lipids;Liver;male;men;Menopausal Status;Menopause;Methodology;Molecular;mortality;mortality risk;novel therapeutics;Obesity;Ovarian;Ovarian Follicle;Pathway interactions;Perimenopause;Physiological;Plasma;Postmenopause;Premenopause;Process;Regulation;reproductive;Research;Risk;Risk Factors;Sampling;secondary analysis;sex;Signal Transduction;steroid hormone;Stroke;stroke risk;Supplementation;Therapeutic;Tissues;transcriptomics;treatment duration;Uterus;Woman;Women's Health

PROJECT_TITLE: Transcriptomic signatures of menopause across human tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(90)S]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Orphan Drug;Rare Diseases

PHR: NARRATIVE. The major limitations in identifying new drugs for salivary gland cancer is that these cancers lack genetic events that can be inhibited conventionally because the gene fusions give rise to abnormal proteins, and there are few reliable models derived from patients. We have discovered a drug (SVC112) that inhibits production of such proteins vital to cancer cells, and we generated human models of this disease, which can actually mimic what happens in a patient more closely, and will make the testing of SVC112 more robust. Our goal is to determine if modulating protein synthesis with SVC112 constitutes a novel therapy for salivary gland cancers, a disease orphan of options.

PI_NAMEs: JIMENO, ANTONIO  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Adenoid Cystic Carcinoma;Affect;antitumor effect;ATP Hydrolysis;Biochemical;Biology;cancer cell;Cancer cell line;Cancer Cluster;Cancer Model;Cancer Patient;Catalogs;Cell Line;Cells;Chimeric Proteins;Clinical;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Colorado;Complex;CRISPR/Cas technology;Cyclin D1;Databases;Dependence;Disease;disease model;Distant Metastasis;Dose;Drug Kinetics;Event;exome sequencing;FDA approved;FRAP1 gene;Frequencies;Gene Fusion;gene product;Genes;Genetic;Genetic Markers;Goals;Growth;Hour;Human;human model;Hypoxia;Implant;in vitro Assay;in vitro Model;in vivo;in vivo evaluation;in vivo Model;inhibitor;Internal Ribosome Entry Site;Invaded;Lentivirus Vector;Malignant neoplasm of salivary gland;Malignant Neoplasms;Measures;Mediating;Messenger RNA;Modeling;Molecular;Molecular Target;Mucoepidermoid Carcinoma;Mus;Mutate;Mutation;neoplastic cell;NFIB gene;novel;novel therapeutics;Oncogenic;Orphan;Other Genetics;overexpression;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Physiological;PIK3CG gene;Population;predictive marker;Predisposition;Production;Proliferating;Property;protein biomarkers;Protein Biosynthesis;Protein Inhibition;Protein Overexpression;Protein Synthesis Inhibition;Proteins;Proteome;Proteomics;Radiation;Rare Diseases;Recurrence;Relapse;Reporting;ribosome profiling;Ribosomes;Role;Seminal;Signal Transduction;small molecule;Solid Neoplasm;spectrograph;Stress;targeted treatment;Testing;Therapeutic;Therapeutic Index;Toxic effect;Transcript;transcription factor;transcriptome sequencing;Translating;Translations;tumor;tumor behavior;tumor growth;tumor initiation;tumorigenic;Tumorigenicity;Unresectable;Up-Regulation

PROJECT_TITLE: Targeting oncogenic Myb fusions in salivary gland cancer with the elongation inhibitor SVC112


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative There is an urgent need for new ways to treat small cell lung cancer (SCLC). SCLC is an aggressive cancer and survival with current therapies is low. While almost all small cell lung cancers have the same known particular gene mutations, so far it has not been possible to develop therapeutic agents to target these gene mutations. We have identified a key vulnerability in SCLC in that SCLC cannot develop in mice when a particular protein is inactivated. Further, we identified an inhibitor of that protein that effectively killed human and mouse SCLC cells. When successfully completed, our studies could lead to clinical trials for the treatment of most SCLC patients.

PI_NAMEs: SCHWARTZ, EDWARD L (contact);ZHAO, HONGLING

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Affect;Alleles;antitumor effect;Apoptosis;Apoptotic;Binding;Biological Markers;Cancer Patient;CDKN1B gene;Cell Cycle Regulation;Cessation of life;Chemoresistance;chemotherapy;Cisplatin;Clinical;clinical predictors;Clinical Treatment;Clinical Trials;clinically relevant;Combined Modality Therapy;Congresses;CRISPR/Cas technology;Data;Disease;Drug Combinations;Drug resistance;Drug Targeting;Drug usage;effective therapy;Etoposide;gain of function mutation;Gene Mutation;Genetic;genome sequencing;Goals;Grant;Growth;Human;human model;In Vitro;in vivo Model;inhibitor;Knock-in Mouse;lung cancer cell;Malignant Neoplasms;Mediating;Metastatic Neoplasm to the Liver;Missense Mutation;Modeling;Molecular Target;mouse model;Mus;mutant;Mutation;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Organoids;Outcome;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;phase III trial;Play;pre-clinical;Proteins;RB1 gene;Regulation;relapse patients;Research;response;Retinoblastoma;Retinoblastoma Protein;Role;small cell lung carcinoma;small molecule;Solid Neoplasm;Specimen;Survival Rate;System;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Agents;Therapeutic Effect;Toxic effect;TP53 gene;treatment strategy;tumor;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;ubiquitin-protein ligase;Ubiquitination;whole genome;Xenograft procedure

PROJECT_TITLE: Vulnerability of SCLC based on bi-allelic genetic inactivation of RB1 and TP53

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Neurodegenerative;Neurosciences;Patient Safety;Peripheral Neuropathy;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE Novel, liquid metal RF coil technology will be developed to enable the design of a conformal and flexible neck-brachial plexus coil array to deliver 3X-higher SNR. We hypothesize that the achievable spatial resolution will be ~0.5 mm isotropic, greater than the ~1 mm isotropic currently afforded by commercial coils. This will enable superior 3D resolution in brachial plexus magnetic resonance neurography, which will improve diagnosis and impact non-operative and operative management.

PI_NAMEs: BALLON, DOUGLAS J (contact);SNEAG, DARRYL

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Anatomy;Architecture;arm;Axilla;Brachial Plexus Neuropathies;Brachial plexus structure;Breast;Characteristics;Chest wall structure;Clinical;clinical decision-making;collaborative environment;Complex;Data;Dedications;design;design and construction;Diagnosis;Diameter;Diffusion;Digit structure;Dimensions;Economics;Electric Capacitance;Electromagnetics;Elements;Engineering;Ensure;Etiology;Evaluation;flexibility;Foundations;Frequencies;Geometry;Goals;Hip region structure;Iatrogenesis;Image;Imaging Phantoms;improved;in vitro testing;Individual;Inflammatory;Inguinal region;innovation;Joints;Knee;Limb structure;Liquid substance;Magnetic Resonance;Magnetic Resonance Imaging;Measurement;medical schools;Meniscus structure of joint;Metals;Morphology;Movement;multidisciplinary;Musculoskeletal;Neck;Nerve;Nerve Fibers;neurovascular;Noise;novel;novel imaging technology;Operative Surgical Procedures;Outcome;Pain;Pathology;Patient imaging;Patients;Pelvis;Peripheral Nerves;Peripheral Nervous System Diseases;Physics;Positioning Attribute;Protocols documentation;prototype;psychologic;radio frequency;Regional Anatomy;Research;Resolution;Rotation;Shoulder;Side;Signal Transduction;simulation;Skin;soft tissue;Special Hospitals;Stretching;Structure;Technology;Testing;Thoracic Outlet Syndrome;Three-Dimensional Imaging;Upper Extremity;Visualization;Work

PROJECT_TITLE: A Self-Tuning Liquid Metal Coil Conforming to Movement for High-Resolution Brachial Plexus MRI

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CORAL GABLES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: In spite of advances due to anti-retroviral therapy and other treatments HIV infection and AIDS-associated Kaposi’ sarcoma continues to be a global health problem affecting many HIV at-risk populations. It is caused by human cancer causing-virus the Kaposi’s sarcoma herpesvirus and interactions with the HIV virus and AIDS. Having proper cellular and mouse tumor models is essential to deeply understand the mechanisms of this dual viral disease. The current application will develop several of these models that will aid our understanding of this viral disease and help design and test therapies.

PI_NAMEs: ROY, SABITA ;SHEMBADE, NOULA DATTU (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Affect;AIDS related cancer;Animal Model;Antibodies;Antibody Therapy;antiretroviral therapy;Automobile Driving;Biology;bone marrow mesenchymal stem cell;Cancer Etiology;Cell Communication;Cell model;Cells;chemotherapy;co-infection;cofactor;Collaborations;common treatment;cytokine;derepression;design;Development;Doxorubicin;Engraftment;epigenome;Evaluation;exhaustion;Fibroblast Growth Factor;Genes;global health;Growth;Herpesviridae Infections;HIV;HIV Infections;HIV-1;HIV/AIDS;Human;Human Herpesvirus 8;IGF2 gene;Immune;Immune checkpoint inhibitor;Immunocompetent;immunodeficiency;Immunologic Tests;Immunologics;immunoregulation;immunosenescence;immunosuppressed;Immunosuppression;Immunotherapeutic agent;Immunotherapy;imprint;In Vitro;in vivo;in vivo Model;Inbred BALB C Mice;Incidence;Individual;Infection;Infiltration;Inflammatory;innovation;Kaposi Sarcoma;Local Therapy;lymph nodes;Macrophage;Mesenchymal Stem Cells;Modeling;Molecular Genetics;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutation;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Nude Mice;Oncogenes;Oncogenic;Pathogenesis;Patients;PD-1/PD-L1;PDGFRA gene;Phenotype;Phosphotransferases;Populations at Risk;pre-clinical;Pre-Clinical Model;pre-clinical research;Preclinical Testing;Principal Investigator;programmed cell death ligand 1;programs;Proteins;Role;stem cell model;Study models;System;T-Lymphocyte;targeted treatment;Testing;Therapeutic;transcriptome;Translational Research;Transplantation;tumor;tumor growth;tumorigenesis;tumorigenic;Tumorigenicity;Viral;Virus;Virus Diseases

PROJECT_TITLE: (PQ6) Mesenchymal stem cell based and immunocompetent mouse models of HIV/AIDS KSHV-driven sarcomagenesis


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The proposed basic research is relevant to public health because it focuses on a fundamental cell process that is critical to development and wound healing and contributes to cancer metastasis. The work will lay the foundation for the development of new strategies to prevent and treat cancer metastasis.

PI_NAMEs: MENDOZA, MICHELLE CHRISTINE (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Acute;Adhesions;Basic Science;Binding;Biology;Biosensor;Bundling;cancer cell;Carcinoma;Cell Adhesion;Cell membrane;Cell model;cell motility;Cell Physiology;Cells;Collagen;Computer Models;Coupled;Data;Development;Disease;Epithelial Cells;ezrin;Foundations;Gel;Goals;Image;improved;Individual;innovation;Integrins;Invaded;Knowledge;Lighting;Location;Malignant Neoplasms;MAP3K1 gene;Measurement;Measures;Mechanics;Mediating;MEKs;Membrane;migration;Migration Assay;Modeling;Molecular;Motion;mutant;Mutation;Neoplasm Metastasis;novel therapeutic intervention;Oncogenes;optogenetics;Output;Pathologic;Pattern;permissiveness;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;polymerization;Polymers;prevent;Process;Protein Kinase;Proteins;Public Health;Receptor Activation;Receptor Protein-Tyrosine Kinases;recruit;Regulation;Relaxation;Research;Role;scaffold;Signal Pathway;Signal Transduction;Site;spatiotemporal;Testing;therapeutic target;time use;tool;Traction;treatment strategy;Width;Work;wound healing;ZYX gene

PROJECT_TITLE: Kinase Control of Synergistic Cell Migration Mechanics

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


ADMINISTERING_IC: EY

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Amblyopia is a prevalent form of visual disability that arises during early childhood and is challenging to treat in adulthood. This proposal seeks to test the specific mechanistic hypothesis that burst-mode firing is responsible for retinal inactivation induced recovery from amblyopic rearing in animal models. Understanding plasticity mechanisms capable of promoting visual acuity gains has the potential to stimulate the development of new treatments for amblyopia and other visual disorders.

PI_NAMEs: LEET, MADISON  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Adult;Age;Amaze;Amblyopia;Animal Model;animal old age;Animals;area striata;Bilateral;Brain;career;Caregivers;Cells;Child;Chronic;Clinical;Cognitive Science;Collaborations;conventional therapy;Development;Disease;Dorsal;early childhood;Equipment;Excision;Excitatory Synapse;Exhibits;experience;experimental study;Eye;Felis catus;Fire - disasters;Functional disorder;Human;in vivo;Individual;Infusion procedures;Injections;Injury;intravitreal injection;Laboratories;Lateral Geniculate Body;Massachusetts;Mediating;Medical;member;Methods;monocular deprivation;mouse model;Mus;Nature;Neurons;novel;novel therapeutic intervention;optogenetics;Pathway interactions;pharmacologic;Photic Stimulation;postsynaptic neurons;Recovery;Reporting;Research;Resistance;Resource Development;Retina;Role;Saline;Sensory Deprivation;Silicon;Slice;Sodium Channel Blockers;stem;T-Type Calcium Channels;Techniques;Technology;Testing;Tetrodotoxin;Thalamic structure;Therapeutic;Time;Training;vision development;Vision Disorders;Visual;Visual Acuity;Visual disability;Visual impairment;Work

PROJECT_TITLE: Elucidating the Role of Dorsal Lateral Geniculate Nucleus Burst-Mode Firing in Retinal Inactivation Induced Recovery from Monocular Deprivation


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Sleep Research

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative Major Depressive Disorder in adolescence often follows a chronic or recurrent course and is associated with significant psychosocial impairment, health problems, school failure, and suicidality; many youth remain substantially symptomatic despite receiving current first-line treatments, underscoring the need for novel, modifiable targets to improve depression treatment outcomes. The overall aim of this proposal is a confirmatory efficacy trial sufficiently powered and designed to test the hypothesis that improving the relationship between biological circadian timing and waketime, a novel modifiable target, improves depression outcomes in a subgroup of adolescents with depression and a misaligned relationship between biological circadian timing and waketime utilizing a cognitive-behavioral sleep intervention. If successful this study will provide a low stigma, safe, data driven precision medicine approach, for improving depression for adolescents with MDD and a misaligned relationship between biological circadian timing and waketime.

PI_NAMEs: ASARNOW, LAUREN  (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: Accidents;active control;Address;Adolescence;Adolescent;Aftercare;anti-depressive agents;Behavior;Behavioral;behavioral sleep intervention;Biological;Blinded;child depression;children's depression rating scale;Chronic;circadian;circadian biology;Circadian Rhythms;clinically significant;Cognitive;confirmatory trial;Data;depressive symptoms;design;Development;Diagnostic;Diet;Dose;efficacy study;evidence base;Exercise;experience;Failure;follow-up;Funding;Future;Health;Impairment;improved;Individual;Intervention;Investigational Therapies;Light;Major Depressive Disorder;Measurement;Measures;Mediating;Melatonin;Mental Depression;Moods;novel;Outcome;Patients;Phase;precision medicine;preference;psychoeducation;psychosocial;Public Health;Randomized, Controlled Trials;Recurrence;Research;response;ROC Curve;Schools;Severities;Sleep;social stigma;Stress;Subgroup;suicidal;Testing;Therapeutic Effect;Time;treatment optimization;Treatment outcome;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: A Confirmatory Efficacy Trial of Engaging a Novel Sleep/Circadian Rhythm Target as Treatment for Depression in Adolescents


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Treatments of malignant gliomas, including glioblastoma multiforme which are the most lethal, fail because cancer cells invade and proliferate beyond tumor boundaries. But neither phenotypes can be tracked clinically with existing imaging methods. We will develop fast 1H/23Na spectroscopic imaging technology to distinguish these phenotypes in parallel, which will have major clinical relevance.

PI_NAMEs: HYDER, DEWAN SYED FAHMEED (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: Acidity;Adjuvant Chemotherapy;Adjuvant Therapy;Biological Markers;Brain Neoplasms;cancer cell;cancer therapy;cariporide;Cell membrane;Cell Physiology;Cell Proliferation;Cell Survival;Cells;chemical property;chemotherapy;Chemotherapy and/or radiation;Clinical;clinically relevant;Computer software;Data;Diagnosis;Diffuse;electrical property;Electrolytes;Gadolinium;Glioblastoma;Goals;Histology;Human;Image;imaging modality;Imaging technology;Immune;Immunotherapy;improved;Individual;Inductively Coupled Plasma Mass Spectrometry;Infusion procedures;inhibitor;Injections;Intercellular Fluid;interstitial;Intracellular Space;Invaded;Ions;Lanthanoid Series Elements;Lead;Libraries;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Malignant Glioma;Malignant Neoplasms;Maps;Membrane;Modeling;Modification;NHE1;Normal Cell;novel;Operative Surgical Procedures;Outcome;patient derived xenograft model;Patients;Pattern;Phenotype;Preclinical Drug Development;preservation;Prognosis;Proliferating;Protons;public health relevance;radio frequency;Recurrence;Research;Saline;Sampling;Scanning;Shapes;single-cell RNA sequencing;sodium ion;Sodium-Hydrogen Antiporter;spatiotemporal;spectroscopic imaging;standard of care;System;Technology;temozolomide;Testing;Tissues;translational approach;tumor;tumor growth;tumor microenvironment;Up-Regulation;Work

PROJECT_TITLE: Interleaved 1H/23Na imaging for invasive and proliferative phenotypes of brain tumors

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Childhood Injury;Clinical Research;Data Science;Emergency Care;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Physical Injury - Accidents and Adverse Effects;Unintentional Childhood Injury

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE Hemorrhage from intraabdominal injury after blunt trauma is a leading cause of death in children in the United States. To identify injury without exposing children to unnecessary ionizing radiation from computed tomography scans requires accurate and reliable diagnostic strategies. The proposed use of machine learning for bedside abdominal ultrasound is an innovative diagnostic tool to enhance the evaluation of injured children and is highly relevant to the mission of The Pediatric Trauma and Critical Illness Branch of the National Institute of Child Health and Human Development to support research and training to improve diagnosis of traumatic injury in infants, children, adolescents, and young adults.

PI_NAMEs: KORNBLITH, AARON EDWARD (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Abdomen;abdominal CT;Abdominal Injuries;Adolescent and Young Adult;Adult;Applied Research;Award;Blunt Trauma;California;career;career development;Cause of Death;Child;Child Care;Childhood;Childhood Injury;Clinical;clinical investigation;Clinical Research;Computing Methodologies;Critical Care;Critical Illness;Data Science;Data Set;Decision Modeling;deep learning;deep learning model;Detection;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Imaging;diagnostic strategy;Diagnostic tests;diagnostic tool;Emergency Care;Emergency Department Physician;Emergency Medicine;Equilibrium;Evaluation;evidence base;experience;Exposure to;Extramural Activities;Failure;Foundations;Funding;Future;Goals;health data;Healthcare;Hemorrhage;Image;implicit bias;improved;improved outcome;Infant;Infrastructure;injured;Injury;innovation;Intervention;Intra-abdominal;Ionizing radiation;Machine Learning;machine learning model;Malignant Neoplasms;Mentors;Methods;Mission;Modeling;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Child Health and Human Development;novel;novel diagnostics;Outcome;patient oriented;pediatric emergency;Pediatric Surgical Procedures;pediatric trauma;Performance;Physicians;point-of-care diagnostics;Positioning Attribute;preventable death;Protocols documentation;Radiation;Radiation exposure;radiation risk;radiological imaging;Reference Standards;Research;Research Activity;Research Design;Research Personnel;Research Support;Risk;San Francisco;Scanning;Scientist;secondary analysis;skills;Specificity;surgical research;Techniques;Testing;theories;Training;Training and Education;Trauma;Traumatic injury;traumatized children;Ultrasonography;ultrasound;United States;Universities;Validation;Work;X-Ray Computed Tomography

PROJECT_TITLE: Accurate and Reliable Diagnostics for Injured Children: Machine Learning for Ultrasound

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The University of Michigan's Program for Scientist Training in Rheumatology Research is designed to prepare four outstanding postdoctoral scientists per year, both MD and PhD, for investigative careers in research related to the rheumatic diseases. The goal is to provide a diverse cohort of trainees essential familiarity with state-of-the-art scientific methodologies and analyses, as well as strong roots in the ethical conduction of research and in embracing a culture of diversity, equity, and inclusion.

PI_NAMEs: KNIGHT, JASON  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Contraception/Reproduction;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Topical Microbicides;Women's Health Research

ORG_CITY: MONROVIA

ORG_NAME: OAK CREST INSTITUTE OF SCIENCE

PHR: PROJECT NARRATIVE Multipurpose prevention technologies (MPTs) that include contraceptive and anti-HIV components have the potential to drive product use and are urgently needed, especially in the developing world. We will use state-of- the-art biology, chemistry, biomedicine, and pharmacology research to develop a novel antibody against sperm and formulate this agent into an intravaginal ring for extended delivery, along with drugs effective against HIV. The proposed research is relevant to public health because it will lead to rigorous development of a much- needed dual-action MPT in preparation for future clinical trials.

PI_NAMEs: BAUM, MARC MICHAEL (contact);LAI, SAMUEL

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: Adherence;Affinity;African Women;Agglutination;AIDS prevention;Animal Model;Anti-Retroviral Agents;Antibodies;Antigen Targeting;arm;Automobile Driving;Behavior monitoring;biocompatible polymer;Biological Assay;Biology;Blocking Antibodies;Cells;Chemistry;Clinical;clinical efficacy;Clinical Trials;Collaborations;Complement;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;cost;cost effective;Data;design;Development;Dose;Drug Combinations;Drug Delivery Systems;Drug Kinetics;Drug Stability;egg;Engineering;Epidemic;fabrication;Family Planning;Future;global health;Goals;health organization;High Risk Woman;HIV;HIV Infections;Hormones;Hour;Human;human male;Hybrids;Immunoglobulin G;In Vitro;in vivo;Individual;Infection;infection rate;innovation;interest;Kinetics;Knowledge;Lead;lead candidate;Macaca;Macaca nemestrina;Measures;Methods;Modeling;Monitor;Monoclonal Antibodies;Mucous body substance;multiple omics;nanomolar;next generation;nonhuman primate;novel;Oral;Persons;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacology;pre-clinical;Pre-Clinical Model;pre-exposure prophylaxis;Pregnancy;Preparation;prevent;Prevention;Process;Property;prototype;Public Health;Regimen;reproductive tract;Research;Research Personnel;response;Risk;Safety;safety assessment;sex;Sheep;simian human immunodeficiency virus;small molecule;Sperm Agglutination;sperm cell;success;Swimming;Technology;Temperature;Temperature Sense;transmission process;unintended pregnancy;uptake;Vagina;vaginal microbiome;Vaginal Ring;Woman;Yeasts

PROJECT_TITLE: Next Generation Multipurpose Prevention Technology: An Intravaginal Ring for HIV Prevention and Nonhormonal Contraception


ORG_DEPT: UROLOGY

PHR: Project Narrative The study proposed here addresses the urgent need to understand the mechanisms of new therapies for type 1 diabetes (T1D), a disease which affects over 1.25 million Americans and has no cure. This project will demonstrate how low-dose IL-2, a promising new T1D immunotherapy, impacts beta cell function beyond increasing survival. The results of this study will provide fundamental knowledge about low-dose IL-2 therapy that will be important to consider as this therapy is brought from bench to bedside.

PI_NAMEs: QURESHI, FARHAN  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Affect;Aftercare;American;analog;Apoptosis;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;bench to bedside;Beta Cell;biological adaptation to stress;Biology;Biomedical Research;Blood;Blood Glucose;blood glucose regulation;Cell Communication;Cell Count;Cell Death;Cell Physiology;Cells;Chimeric Proteins;Clinical;Clinical Research;Clinical Trials;Cyclosporine;cytokine;Data;Diabetes Mellitus;diabetes pathogenesis;diabetic;Diagnosis;Disease;Disease Progression;Dose;effector T cell;efficacy trial;Endocrine;Endoplasmic Reticulum;Environment;Fasting;Fluorescence-Activated Cell Sorting;Foundations;Functional disorder;functional restoration;glucose tolerance;Goals;Half-Life;Health;Homeostasis;IL2RA gene;Immune;immune cell infiltrate;Immune Tolerance;immunoregulation;Immunosuppressive Agents;Immunotherapy;Impairment;In Situ;In Vitro;Inbred NOD Mice;Individual;Infiltration;Inflammatory;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;insulitis;Interleukin-2;Intervention;Investments;islet;Islets of Langerhans;Knowledge;Lymphocyte;Mediating;Modeling;Monitor;neglect;Non obese;NOR Mouse;novel;novel strategies;novel therapeutics;Pancreas;Pathogenesis;Patients;Pattern;Phase I/II Clinical Trial;Population;Pre-Clinical Model;preclinical study;preclinical trial;Preparation;preservation;prevent;Prevention;Proliferating;Recombinant Interleukin-2;Regulatory T-Lymphocyte;response;restoration;Science;Signal Transduction;single-cell RNA sequencing;Slice;Stains;Strategic Planning;Stress;Testing;Time;Tissues;Treatment Efficacy;United States National Institutes of Health;Work

PROJECT_TITLE: The Effects of Low-Dose IL-2 Therapy on Beta Cell Dysfunction  in Type 1 Diabetes


NIH_SPENDING_CATS: Genetics

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE  Pre-mRNA splicing is an essential component of gene expression for eukaryotic organisms. An ever-increasing number of human diseases are associated with mutations in this pathway, yet the mechanisms by which the spliceosome, which catalyzes pre-mRNA splicing, enacts this regulation is a complex problem whose solution remains poorly understood. By leveraging novel tools developed in our lab that enable detection of rare reaction intermediates, we are determining the basic mechanisms by which the spliceosome distinguishes between its many substrates.

PI_NAMEs: PLEISS, JEFFREY A (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Acceleration;Alleles;Alternative Splicing;Area;base;Cell Culture Techniques;Chemicals;Chromatin;Complement;Complex;Coupling;Data;Deceleration;Detection;Disease;DNA-Directed RNA Polymerase;Elements;Environment;Enzymes;Equilibrium;Etiology;Eukaryota;experimental study;Fission Yeast;Gene Expression;Gene Structure;Genes;Genetic;Genetic Transcription;genetic variant;genome-wide;Goals;Human;human disease;improved;in vivo;Individual;insight;Introns;Kinetics;Knowledge;Label;Mammalian Cell;Measurement;Measures;Metabolic;Methodology;Molecular;Monitor;mRNA Precursor;Mutation;novel;Organism;Pathway interactions;Primer Extension;Process;Property;Protein Isoforms;Proteome;Reaction;Regulation;Regulatory Element;Resolution;RNA;RNA Splicing;RNA, Messenger, Splicing;Role;Saccharomycetales;Site;Spliceosome Assembly Pathway;Spliceosomes;Techniques;Testing;tool;Transcript;Transcription Elongation;transcriptome sequencing;Variant;Work;Yeasts

PROJECT_TITLE: Revealing molecular determinants of transcript-specific regulation in pre-mRNA splicing via rapid in vivo kinetic rate measurements

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: OVERALL COMPONENT: PROJECT NARRATIVE The proposed award will support infrastructure designed to enhance population science. It will promote innovative research on the social, institutional, and environmental dimensions of population structures and processes that are fundamental to health and well-being.

PI_NAMEs: JACKSON, MARGOT  (contact)

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Area;Award;Bangladesh;Brazil;Censuses;Child;China;Collaborations;Communities;Costa Rica;Country;Creativeness;Data;Dedications;Demography;design;Development;Dimensions;Ecuador;Environment;Ethiopia;Faculty;Family;flexibility;Fostering;Foundations;Funding;Health;health disparity;health disparity populations;HIV/AIDS;India;Individual;Infrastructure;innovation;Institution;International;Investments;Kenya;Knowledge;low and middle-income countries;Mentors;Methodology;Methods;Mexico;mid-career faculty;migration;National Institute of Child Health and Human Development;next generation;Nigeria;Personal Satisfaction;Peru;Philippines;Population;population health;Population Research;Population Sciences;Population Study;privacy protection;Process;programs;Public Health;Reproductive Health;Research;Research Activity;Research Design;Research Infrastructure;Resources;Science;Scientist;Services;social;Social Sciences;sociologist;South Africa;Structure;Time;Training;Universities;Urbanization;Work

PROJECT_TITLE: Brown Population Studies and Training Center


PROJECT_TERMS: Award;career;community building;cost effective;Creativeness;Development;Environment;Exposure to;Faculty;flexibility;Fostering;Goals;Grant;Individual;Investments;Leadership;next generation;Population;Population Research;Population Sciences;Population Study;Productivity;programs;Reporting;Research;Research Infrastructure;Scientist;Services;Teacher Professional Development;Time;Training

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cardiovascular;Prevention

PHR: PROJECT NARRATIVE Aortic aneurysm is an asymptomatic disease but has a high mortality rate and there are no drugs for treatment. The causes of aortic aneurysm are poorly understood. These studies address a new mechanism likely contributing to aortic aneurysm and set the stage for a possible new treatment for this disease using a new class of drugs currently in clinical trials for other diseases.

PI_NAMEs: CHEN, YUQING EUGENE (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: Acceleration;Address;Adipocytes;adipokines;Adipose tissue;Affect;Aneurysm;Aorta;Aortic Aneurysm;Apoptosis;Atherosclerosis;Blood Vessels;Brown Fat;Cardiac;Cardiovascular Diseases;Characteristics;Chest;Clinical;clinical translation;Clinical Treatment;Clinical Trials;Coculture Techniques;Conditioned Culture Media;Data;Death Rate;Development;Disease;Dissection;epidemiology study;Fatty acid glycerol esters;Fatty Acids;Functional disorder;gain of function;Generations;Genes;genetic approach;Genetic Predisposition to Disease;Health;Heritability;Homeostasis;Human;Hypertension;In Vitro;in vivo;Induction of Apoptosis;Inflammation;Inflammatory;inflammatory marker;Infusion procedures;knock-down;Knockout Mice;Knowledge;Lesion;Life;loss of function;Mediating;Metabolic Diseases;Modeling;Morbidity - disease rate;mortality;Mus;nitrated conjugated linoleic acid;Nitrogen Dioxide;novel;novel drug class;novel therapeutic intervention;Operative Surgical Procedures;Other Genetics;Outcome;overexpression;Oxidative Stress;paracrine;Pathology;Patients;perioperative mortality;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase II Clinical Trials;prevent;Process;programs;Property;Proteins;repaired;Repression;Research;resistin;Risk Adjustment;Role;Rupture;Signal Transduction;Smooth Muscle Myocytes;Testing;Thoracic Aortic Aneurysm;Transgenic Mice;Vascular Diseases;Vascular Smooth Muscle;Work

PROJECT_TITLE: Browning of perivascular adipose tissue protects against thoracic aortic aneurysm

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: QIAN, ZHENCHAO  (contact)

PROJECT_TERMS: Area;career;Creativeness;Development;Educational workshop;faculty support;Funding;Goals;Grant;high risk;innovation;Investments;Learning;Mentors;mid-career faculty;Persons;Population;Population Sciences;Population Study;programs;Research;research and development;Scholars Program;Scientist;success;Talents;Training;Visit;visiting scholar;Writing

PROJECT_TITLE: Development Core


ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE KRAS mutations are found in approximately one fourth of lung cancers, a disease that kills approximately 160,000 people annually in the U.S. The treatment of patients with this molecular subtype of lung cancer remains one the biggest challenges faced by medical oncologists. This proposal will study how patients and patient-derived models respond to emerging inhibitors that directly inactivate mutant KRAS in order to develop effective treatments that prolong survival and improve the quality of life in patients with lung cancer.

PI_NAMEs: LITO, PIRO  (contact)

PROJECT_TERMS: Affect;Attenuated;Bar Codes;Binding;Biopsy Specimen;Bypass;cancer cell;Cancer Etiology;Cells;Clinic;Clinical;clinical development;clinical translation;Clinical Trials;Combined Modality Therapy;Coupled;Data;Development;Diagnosis;Disease;Drug Modulation;Drug Targeting;effective therapy;Ensure;Evaluation;first-in-human;gain of function;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Heterogeneity;improved;inhibitor;innovation;Interferons;KRAS2 gene;Longitudinal Studies;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Medical Oncologist;Modeling;Molecular Conformation;molecular subtypes;mortality;mutant;Mutation;Nature;Nucleotides;objective response rate;Oncoproteins;Patients;Persons;Pharmaceutical Preparations;Phenotype;Play;Population;pre-clinical;precision oncology;preclinical development;preclinical study;Process;Progression-Free Survivals;Prospective Studies;Protein Isoforms;Quality of life;Ras Inhibitor;Reporting;Reproducibility;research clinical testing;Research Personnel;Resistance;Resistance development;response;Science;Signal Transduction;Specimen;success;Testing;Therapeutic;Time;Transforming Growth Factors;Translating;treatment response;treatment strategy;United States Food and Drug Administration;Work

PROJECT_TITLE: Mechanisms of adaptation and resistance to emerging therapies for lung cancer

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE The central control of reproductive function has focused mainly on the hypothalamic neurons that control GnRH release, however, the amygdala, located outside of the hypothalamus has been documented to participate in the control of reproduction through yet unknown mechanisms. Our preliminary data suggests that Kiss1 neurons in this brain region play a critical role in reproduction. We will test this hypothesis through a series of genetic, optogenetic and pharmacological studies aimed to target these neurons in both sexes to determine their role in gonadotropin release and sexual behavior.

PI_NAMEs: NAVARRO, VICTOR MANUEL (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Ablation;Acute;Amygdaloid structure;Area;Behavior;Brain region;Calcium;Cell Nucleus;comparison control;Cues;Data;Development;Efferent Neurons;Exposure to;Female;Fertility;Fiber;Frequencies;Generations;Genes;Genetic;genetic manipulation;Genetic study;Goals;Gonadotropin Hormone Releasing Hormone;Gonadotropins;Hormonal;Hypogonadism;hypothalamic pituitary gonadal axis;Hypothalamic structure;Impairment;Induction of Apoptosis;innovation;insight;Investigation;KISS1 gene;Knowledge;Label;Lesion;Libido;Lordosis;male;Maps;Medial;Mediating;Mus;Neurons;Neuropeptides;optogenetics;Ovulation;Partner in relationship;Pharmacology Study;Pheromone;Photometry;Physiologic pulse;Play;Population;postsynaptic neurons;Preoptic Areas;Protocols documentation;Reproduction;reproductive;reproductive axis;Reproductive Behavior;reproductive function;reproductive system disorder;Role;Series;sex;Sex Behavior;Sex Differentiation;Structure of nucleus infundibularis hypothalami;Testing;Time;Time Study;Tracer;Urine;Ventricular;Virus

PROJECT_TITLE: Characterization of the role of the amygdala in reproductive function

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE DEPARTMENT OF HEALTH

PHR: Project Narrative It is important to monitor factors that contribute to the health of mothers and their infants. The proposed research project, Florida Pregnancy Risk Assessment Monitoring System (PRAMS), seeks to collect valuable information about specific maternal and child health (MCH) issues that can only be achieved through the collection and utilization of population-based MCH data. Objectives include collecting PRAMS data to assess factors that contribute to infant mortality, improve prenatal care for expecting mothers, and strengthen programs to improve the health of women and children within Florida.

PI_NAMEs: LAKE-BURGER, HEATHER  (contact)

PROJECT_TITLE: DP21-001 Florida Pregnancy Risk Assessment Monitoring System


ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA STATE DEPT OF HEALTH

ORG_STATE: VA

PHR: Component A Project Narrative Specific Aims Virginia PRAMS (Pregnancy Risk Assessment Monitoring System) supports the activities of the Virginia Department of Health (VDH) to improve maternal and child health in the Commonwealth through: 1) Surveillance of selected maternal behaviors and experiences that occur prior to,  during, and after pregnancy; 2) Providing a high quality data source for ongoing monitoring of risk factors for  maternal and infant health; 3) Addressing emerging issues, including post-disaster or pandemic surveillance  needs, through the use of survey supplements, and; 4) Provision of data collection results to be used for program planning and evaluation.

PI_NAMEs: SMITH BARBER, KENESHA  (contact)

PROJECT_TITLE: RFA-DP-21-001 DP006624 VA Pregnancy Risk Assessment Monitoring System (PRAMS)


NIH_SPENDING_CATS: Dissemination and Implementation Research

PI_NAMEs: LINDSTROM, DAVID P. (contact)

PROJECT_TERMS: Adoption;Computer software;Data;Data Analyses;data centers;Data Collection;data dissemination;data integration;Data Sources;Diffusion of Innovation;Faculty;Goals;Infrastructure;innovation;Interdisciplinary Study;Maintenance;Methods;new technology;novel strategies;Pilot Projects;Population;Population Research;Population Sciences;Population Study;Productivity;programs;Research;Research Personnel;Research Project Grants;Research Support;Science;Scientist;Secure;Services;Surveys;Technology;Time;tool;Training;Training and Education

PROJECT_TITLE: Science/Technical Core


ORG_CITY: LANSING

ORG_NAME: MICHIGAN STATE DEPARTMENT OF HEALTH AND HUMAN SERVICES

PHR: MI PRAMS COMPONENT A - PROJECT NARRATIVE The Michigan Pregnancy Risk Assessment Monitoring System (MI PRAMS) is an annual survey of the health of mothers and babies within the State of Michigan. The survey is sent out to a portion of women randomly selected from all Michigan residents who have a live birth in the state during a given year and is vital for knowing how common are the factors that can have positive or negative effects on a pregnancy. The end result of MI PRAMS is a collection of annual estimates that represent the health of all mothers and babies in the State; these estimates are useful for planning government spending and tracking the success of programs that improve maternal and child health.

PI_NAMEs: FUSSMAN, CHRIS  (contact)

PROJECT_TITLE: RFA-DP-21-001 DP006592 Component A - Michigan Pregnancy Risk Assessment Monitoring System (8.11.20)


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE: The American Heart Association estimates that 2.5% of the United States population suffers from valvular heart disease, requiring over 100,000 heart valve replacement procedures annually. Replacement of the diseased valve dramatically improves short-term quality and quantity of life, however, even the best performing replacement valves used currently (i.e., biological tissue valves) are far from ideal, as they promote chronic immune-mediated degeneration, resulting in calcification and long-term valve failure (~10-15 years). The current proposal aims to fulfill recent NHLBI cardiac surgery working group recommendations; by identifying and eliminating biological tissue components which promote immune-mediated destruction, while simultaneously enhancing components which promote pro-regenerative immune responses, to provide the next generation of tissue engineered heart valve biomaterials which retain the benefits of current heart valve replacements, while overcoming their negative long term outcomes.

PI_NAMEs: GRIFFITHS, LEIGH GARETH (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: adaptive immune response;Address;Age;American Heart Association;Animal Model;Antigen Targeting;Antigens;Biocompatible Materials;Biological;Biomaterials Research;Bioprosthesis device;calcification;Cardiac Surgery procedures;cardiac tissue engineering;Cattle;Child;Chronic;Clinical;clinical practice;clinical translation;design;Development;Disease;Ensure;Excision;Experimental Designs;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Failure;Fibrosis;Generations;Glutaral;Goals;Heart Valve Diseases;Heart Valve Prosthesis;heart valve replacement;Heart Valves;Heterophile Antigens;Human;Immune;Immune mediated destruction;Immune response;Immune Tolerance;immunogenic;immunogenicity;Immunologics;Immunology;implantation;improved;In Vitro;in vivo;Individual;Inflammatory;Innate Immune Response;innovation;insight;Knowledge;Life;longitudinal design;Macrophage;Mediating;Modeling;Molecular Structure;National Heart, Lung, and Blood Institute;next generation;Outcome;oxidation;Patients;pericardial sac;Phase;Play;Population;Prevalence;prevent;Procedures;Production;Property;Protein Chemistry;Proteomics;Protocols documentation;rational design;receptor;Recommendation;regenerative;Regenerative response;Reporting;Residual state;response;Role;Safety;scaffold;Sheep;sheep model;Signal Transduction;Site;Source;success;Tissue Engineering;Tissues;translation to humans;translational barrier;Translations;United States;valve replacement;working group;Xenograft procedure

PROJECT_TITLE: Immunology of xenogeneic extracellular matrix scaffolds for heart valve tissue engineering

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: R01: Investigating the impact of a fatty acid–cRel inflammatory circuit in atherosclerosis RELEVANCE TO PUBLIC HEALTH Perturbed lipid homeostasis is associated with pathogenic inflammation in a number of metabolic diseases, including atherosclerosis, obesity, and diabetes. In this study, we will elucidate the mechanisms underlying the link between altered lipid metabolism and aberrant inflammatory responses. Our findings may lead to the identification of therapeutic targets in cardiovascular diseases and other metabolic disorders.

PI_NAMEs: BENSINGER, STEVEN J (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: advanced analytics;Affect;Anti-Inflammatory Agents;Arterial Fatty Streak;ATAC-seq;atherogenesis;Atherosclerosis;Attenuated;Cardiometabolic Disease;Cardiovascular Diseases;Cardiovascular system;Cells;ChIP-seq;Cholesterol Homeostasis;Chronic;Cues;Cytokine Signaling;Data;Data Set;design;Diabetes Mellitus;differentiation in vitro;Disease;Dyslipidemias;endoplasmic reticulum stress;Enzymes;Epigenetic Process;epigenome;Event;expectation;Family member;fatty acid metabolism;Fatty Acids;Genetic Models;Genetic Transcription;Goals;Grant;Homeostasis;human disease;Immune;immune activation;in vivo;Inflammation;Inflammatory;Inflammatory Response;Interferons;Laboratories;Lead;Link;lipid metabolism;lipidome;lipidomics;Lipids;long chain fatty acid;Macrophage;Maps;Mass Spectrum Analysis;member;Metabolic;Metabolic Diseases;Metabolism;Modeling;Molecular;monocyte;Monounsaturated Fatty Acids;Mus;novel;Obesity;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;Polyunsaturated Fatty Acids;Process;programs;Proteins;Public Health;receptor;Reporting;response;Role;Saturated Fatty Acids;Shapes;Shotguns;Signal Pathway;Signal Transduction;stable isotope;Techniques;Testing;Therapeutic Intervention;therapeutic target;Tissues;TLR2 gene;TLR3 gene;TLR7 gene;Tracer;transcription factor;transcriptomics;Up-Regulation;Vascular Endothelium;western diet;Work

PROJECT_TITLE: Investigating the impact of a fatty acid-cRel inflammatory circuit in atherosclerosis

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]