NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Prevention;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: RELEVANCE TO PUBLIC HEALTH Glioblastoma (GBM) is the most common primary brain tumor in adults and one of the deadliest cancers, with a median survival of only 12-16 months from diagnosis even with extensive treatments. This application aims to elucidate the critical role of lipid storage in regulating lipid homeostasis and GBM growth, as well as to use this insight to identify and test promising combinatorial pharmacological approaches to effectively target GBM in preclinical models in order to ultimately translate them to the clinic.

PI_NAMEs: GUO, DELIANG  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Antioxidants;Autophagocytosis;Biology;Brain Neoplasms;Cell Death;cell growth;cell injury;Cell membrane;Cell Proliferation;Cells;Cellular Membrane;Cellular Structures;Cholesterol;cholesterol control;Cholesterol Esters;Cholesterol Homeostasis;Clinic;combinatorial;Cystine;Data;Defense Mechanisms;diacylglycerol O-acyltransferase;Diagnosis;Drops;Drug Metabolic Detoxication;effective therapy;endoplasmic reticulum stress;Enzymes;experimental study;fatty acid oxidation;Fatty Acids;Funding;Genes;Glioblastoma;Glucose;Goals;Growth;Homeostasis;Hydrolysis;In Vitro;in vivo;Induction of Apoptosis;inhibition of autophagy;insight;Laboratories;lipidomics;Lipids;Malignant Neoplasms;Measures;Mediating;Membrane;Membrane Structure and Function;Metabolism;Mitochondria;Names;neoplastic cell;novel;novel strategies;Oleic Acids;Outcome;oxidation;Pathway interactions;pharmacologic;Play;pre-clinical;Pre-Clinical Model;prevent;Primary Brain Neoplasms;Prognosis;Public Health;Reactive Oxygen Species;Regulation;Resistance;Resources;response;Role;Starvation;Stearic Acids;Stearoyl-CoA Desaturase;synergism;Testing;Therapeutic;therapeutically effective;Tissues;Toxic effect;Translating;Triglycerides;tumor;tumor growth;Up-Regulation;uptake;Xenograft Model

PROJECT_TITLE: Determining the role of lipid droplets and their therapeutic potential in glioblastoma


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: STONY BROOK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Bioactive sphingolipids are a class of lipids (fatty molecules) which are emerging as important regulators of cell functions, including effects on cell growth, cell death, and cell migration, and the bioactive sphingolipid ceramide is a key molecule in sphingolipid metabolism and function. Our studies have implicated this lipid in regulating cell growth and death, and in this proposal, we focus on a novel pathway mediated by this lipid which is located in the plasma membrane, and we also focus on the mechanisms by which this pathway regulates cancer cell migration and adhesion, key events in cancer progression. By dissecting out the molecular mechanisms of this pathway, we stand to not only advance our basic science understanding of how these molecules operate, but we anticipate to advance novel targets for cancer therapy.

PI_NAMEs: HANNUN, YUSUF AWNI (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: acid sphingomyelinase;Acute;Address;Adhesions;Apoptosis;Basic Science;Biochemical;biological adaptation to stress;Biological Assay;cancer cell;Cell Adhesion;Cell Death;cell fixing;cell growth;Cell membrane;cell motility;Cell Physiology;Cells;Ceramidase;Ceramides;Cessation of life;combinatorial;Development;Elements;Enzymes;Event;experimental study;ezrin;Family;Generations;Goals;Grant;Growth;Human;Hydroxylation;In Vitro;Length;Lipids;liquid chromatography mass spectrometry;Measures;Mediating;Membrane;Membrane Microdomains;Metabolism;migration;Molecular;novel;Pathway interactions;Phorbol Esters;Phosphoric Monoester Hydrolases;Production;Productivity;programs;Protein Dephosphorylation;Protein phosphatase;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;Publishing;Quantitative Evaluations;Regulation;response;Role;Scheme;senescence;Signal Pathway;Signal Transduction;Sphingolipids;Sphingomyelinase;Sphingosine;stem;Stimulus;targeted cancer therapy;Time;TNF gene;tumor progression

PROJECT_TITLE: Ceramide Activated Protein Phosphatases

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project narrative This project is relevant to public health because it attempts to bridge the persistent gap between research and real world policy with the use of a method informed by interdisciplinary scholarship in public policy, public administration, health codesign, and research evidence translation. The studied method, Policy Codesign, is already of significant interest to real world policy makers and behavioral health policy intermediaries and this study will inform efforts to ready the approach for further testing and dissemination.

PI_NAMEs: WALKER, SARAH CUSWORTH (contact)

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;adolescent substance use;Advocacy;Affect;Area;arm;Articulation;behavioral health;behavioral health intervention;Benchmarking;Caring;Child Mental Health;cohesion;Collaborations;Communities;community engaged research;community engagement process;Complex;Connecticut;Country;County;County Government;Data;design;disorder prevention;effectiveness trial;Engineering;Equilibrium;evidence base;Evidence based practice;Failure;Focus Groups;Funding;Geography;Goals;Government;Growth;Health;health care delivery;Health Policy;Health Services Research;Health system;Human Resources;ideation;implementation barriers;implementation science;improved;Individual;information gathering;innovation;interest;Intervention;Interview;Justice;Literature;longitudinal design;Maps;Measures;member;Methodology;Methods;Modeling;National Institute of Drug Abuse;National Institute of Mental Health;New York;Observational Study;Outcome;Participant;Pathway Analysis;Phase;Pilot Projects;Policies;Policy Developments;Policy Maker;Policy Making;Politics;Positioning Attribute;Procedures;Process;prototype;Public Health;Public Policy;Recommendation;Reporting;Research;Research Personnel;Research Priority;Resources;satisfaction;Scholarship;Science;Science Policy;service providers;Services;Social Network;Structure;Substance Use Disorder;substance use prevention;success;Surveys;Testing;Thinking;tool;Translating;Translations;United States;United States National Institutes of Health;usability;violence prevention;Washington;young adult;Youth

PROJECT_TITLE: Using policy codesign to achieve multi-sector alignment in adolescent behavioral health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Charcot-Marie-Tooth Disease;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Peripheral Neuropathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE CMT is a genetically and phenotypically diverse neuromuscular disorder and dominant mutations in 6 different tRNA synthetases cause forms of CMT. These synthetase enzymes are essential for protein synthesis and our recent work suggests that mutant synthetases activate an integrated stress response (ISR) that leads to two major cellular events: 1) a shutdown of one form of protein translation/production and, 2) upregulation of the transcription factor, ATF4, and its target genes. The goal of this project is to determine the role of ATF4 and target gene expression in CMT pathophysiology using transgenic mice, and then to use human induced pluripotent stem cell-based models with CMT-causing mutations to confirm the ISR in human motor neurons, facilitate further mechanistic experiments, and assess novel therapeutics.

PI_NAMEs: HINES, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: adenovirus mediated delivery;Affect;afferent nerve;Alleles;Amino Acids;Amino Acyl-tRNA Synthetases;Autopsy;Axon;Binding;biological adaptation to stress;Biological Models;career;career development;Career Transition Award;causal variant;Cell Fraction;Cell Line;Cells;Charcot-Marie-Tooth Disease;Charge;Clustered Regularly Interspaced Short Palindromic Repeats;Data;data integration;Defect;Demyelinations;differential expression;directed differentiation;Disease;disease phenotype;disease-causing mutation;Distal;dominant genetic mutation;Drug usage;EIF-2alpha;Engineering;Ensure;Enzymes;Event;experimental study;Family;FGF21 gene;fibroblast growth factor 21;Functional disorder;GDF15 gene;Gene Expression;Gene Family;gene replacement;Genes;Genetic Engineering;Goals;Hereditary Disease;Histology;Human;human disease;human induced pluripotent stem cells;human stem cells;Immunofluorescence Immunologic;In Vitro;in vivo;Inherited;Knock-out;Ligase;Link;Mammalian Genetics;Measures;Mediating;Mentors;Methods;Modeling;Morphologic artifacts;Motor;Motor Neurons;mouse model;Mus;mutant;Mutation;Nerve Degeneration;neuromuscular;Neuromuscular Diseases;Neuromuscular Junction;neuronal cell body;Neuronal Dysfunction;Neuropathy;novel therapeutics;overexpression;Paper;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Peptide Initiation Factors;Peripheral Nerves;Peripheral Nervous System Diseases;Persons;Phase;Phenotype;Phosphorylation;Phosphotransferases;Physiology;Postdoctoral Fellow;prevent;Production;Protein Biosynthesis;protein expression;Proteins;Proteomics;Publishing;Quantitative Reverse Transcriptase PCR;Rare Diseases;Reagent;Resource Development;response;Review Literature;Ribosomes;RNA Interference;Role;Sampling;Science;sensor;Series;Serum;Skeletal Muscle;Source;Spinal Cord;stem cell model;System;targeted treatment;Testing;The Jackson Laboratory;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;Tissue Sample;tool;Tooth Diseases;Training;transcription factor;transcriptome sequencing;transcriptomics;Transfer RNA;Transgenic Mice;Translations;Tyrosine-tRNA Ligase;Up-Regulation;Variant;Western Blotting;Work;YARS gene

PROJECT_TITLE: Understanding the Role of the Integrated Stress Response in tRNA Synthetase-associated Charcot-Marie-Tooth Disease


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Antimicrobial Resistance;Behavioral and Social Science;Bioengineering;Clinical Research;Health Services;Infectious Diseases;Lung;Pediatric

ORG_CITY: Moshi

ORG_COUNTRY: TANZANIA U REP

ORG_FIPS: TZ

ORG_NAME: KILIMANJARO CHRISTIAN MEDICAL CENTRE

PHR: Project Narrative While respiratory tract infections in young are a leading cause of preventable deaths among children < 5 years of age in low- and middle-income countries, the majority of respiratory tract infections are caused by viruses and usually not life-threatening and these cases represent one of the leading scenarios where antibiotics are inappropriately utilized by healthcare providers and patient caregivers. This project aims to create a clinical decision support algorithm that will empower healthcare providers and reassure caregivers in Tanzania by identifying patients with respiratory tract infection where antibiotics are appropriate and respiratory tract infection cases where antibiotics are neither necessary nor appropriate. Developed with the end-user in mind through input and engagement of caregivers and providers, this clinical decision support algorithm will have the potential to make an impact on child health by optimizing management of respiratory tract infections in young children and by reducing exposure to unnecessary antibiotics, a major driver of antibiotic resistance.

PI_NAMEs: NGOCHO, JAMES SAMWEL (contact)

PROGRAM_OFFICER_NAME: POVLICH, LAURA

PROJECT_TERMS: 5 year old;Acceleration;Address;Africa;Africa South of the Sahara;African;algorithm development;Algorithms;Ambulatory Care;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Area;Asia;Attitude;Award;Behavioral Sciences;Biological Markers;career;career development;Caregivers;Case Management;Characteristics;Child;Child Health;Childhood;Clinical;clinical decision support;clinical decision-making;clinical epidemiology;clinical examination;clinical practice;clinical predictors;Clinical Research;cohort;Cohort Studies;Collaborations;Communicable Diseases;Country;Data;Data Science;Dedications;design;Diagnosis;Disease;Disease Management;early childhood;efficacy testing;Environment;Epidemiology;Etiology;Evaluation;evidence base;expectation;experience;Exposure to;Feasibility Studies;Funding;Future;Gambia;Genes;Goals;Health care facility;health care service utilization;health empowerment;Health Personnel;High Prevalence;Hospitalization;Human;human centered design;improved;infection management;Infectious Disease Epidemiology;Infectious Diseases Research;innovation;Intervention;K-Series Research Career Programs;Life;low and middle-income countries;Lower Respiratory Tract Infection;Lower respiratory tract structure;Mali;Medical;Medical center;Medical Education;Mentors;Mentorship;Messenger RNA;Methodology;Methods;mortality;novel marker;Outpatients;Patients;Performance;Pneumonia;point of care;preventable death;Primary Care;prognostic;Program Development;programs;prospective;protein biomarkers;Provider;Public Health;Research;Research Personnel;research study;Resources;Respiratory Tract Infections;Risk;risk stratification;Running;Safety;Sampling;Serum Proteins;Severity of illness;Site;skill acquisition;skills;Social Behavior;social science research;South Africa;Specificity;support tools;Syndrome;Tanzania;Teacher Professional Development;Testing;therapy design;therapy development;Time;tool;Training;Training Programs;United States National Institutes of Health;Universities;user-friendly;Viral;Viral Respiratory Tract Infection;Virus;Visit;Work

PROJECT_TITLE: Clinical decision support algorithm to optimize management of respiratory tract infection in children attending primary health facilities in Kilimanjaro Region, Tanzania

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-J(55)R]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: Innovative methods for early detection of the alterations in brain function underlying autism spectrum disorder prior to manifestation of behavioral symptoms are necessary to advance treatment strategies and improve prognoses. This grant will develop a high performance naturalistic optical neuroimaging device and complementary naturalistic functional imaging paradigms and analysis methods for mapping typical and atypical brain development.

PI_NAMEs: CULVER, JOSEPH P (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Adolescent;Adult;Affect;Algorithms;Anatomy;Atlases;Atypical autism;autism spectrum disorder;awake;behavioral response;Behavioral Symptoms;Brain;Brain Diseases;Brain Mapping;Breathing;Child;Comparative Study;Complement;computerized tools;density;design;Detection;detection sensitivity;Development;Devices;diffuse optical tomography;Digital Signal Processing;Early Diagnosis;Early Intervention;Environment;ergonomics;experience;Fiber;Fiber Optics;flexibility;Floor;Functional Imaging;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Future;General Population;Grant;Head;Helmet;Human;Image;improved;improved outcome;In Situ;innovation;instrument;instrumentation;Life;Light;light weight;Loudness;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methodology;Methods;Modeling;Modernization;Motion;movie;multimodality;Multivariate Analysis;Neurodevelopmental Disorder;neuroimaging;Noise;Optics;Participant;Pattern;Performance;photomultiplier;Physiological Processes;Population;Predisposition;preservation;Prognosis;Protocols documentation;Reproducibility;Resolution;response;Rest;School-Age Population;Signal Transduction;Silicon;Specificity;statistics;Stimulus;Surface;System;Television;Toddler;Translating;treatment strategy;Validation;wearable device

PROJECT_TITLE: Naturalistic Brain Mapping in Children with Diffuse Optical Tomography

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Pediatric;Psychosis;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Children and adolescents with early onset psychosis (EOP) have a dramatically increased prevalence of rare genetic mutations compared to adult-onset cases. We will acquire the largest EOP sample to date to search for inherited and de novo protein altering mutations predisposing this debilitating illness.

PI_NAMEs: ALMASY, LAURA A.;BUSTAMANTE, CARLOS DANIEL;GLAHN, DAVID C (contact);NICOLINI, HUMBERTO

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Admixture;admixture mapping;Adolescent;Adult;African;Alleles;ancestry analysis;autism spectrum disorder;Bipolar Disorder;Brain;Caribbean region;Central American;Characteristics;Child;Childhood;Cities;Clinical;clinical heterogeneity;Cognitive;cohort;comparison control;Complex;Control Groups;de novo mutation;Diagnosis;Diagnostic;Diagnostic Procedure;DNA Sequence Alteration;dosage;early life adversity;early onset;Environmental Risk Factor;ethnic minority;Etiology;European;European ancestry;Event;Exclusion;exome;exome sequencing;Family;Family Demographies;Family member;Frequencies;gene environment interaction;Gene Frequency;Genes;genetic architecture;genetic association;Genetic study;Genome;genome-wide;genome-wide analysis;genomic locus;Haplotypes;health care disparity;Heterogeneity;High Prevalence;Hospitals;Impaired cognition;Impairment;Income;indexing;Indigenous American;Individual;Inherited;Interview;Latino Population;Lead;Life;loss of function;loss of function mutation;marijuana use;Mexican;Mexico;Mutation;National Institute of Mental Health;Neighborhoods;neurocognitive test;Neurodevelopmental Disorder;Neurons;Outcome;Outpatients;Parents;Participant;Phenotype;Population;Population Control;Prevalence;Privatization;proband;Procedures;Proteins;Psychiatric Hospitals;psychogenetics;Psychoses;psychosis risk;psychosocial;Psychosocial Assessment and Care;Psychotic Disorders;Publishing;racial minority;recruit;Recurrence;Risk;risk variant;Running;Sampling;Schizophrenia;Severities;Siblings;social determinants;Socioeconomic Status;South American;Testing;trait;Variant;Virulent;Visit;whole genome;Youth

PROJECT_TITLE: Genetic Architecture of Early-Onset Psychosis in Mexicans (EPIMex)

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: CORAL GABLES

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Screening for prostate cancer reduces the risk of prostate cancer death but subjects an overwhelming number of men to unnecessary biopsies and the risk of being over treated. Extracellular vesicles (EVs) released into the urine of prostate cancer patients are promising liquid biomarkers and selecting EVs that have a surface protein called PSMA (prostate specific membrane antigen) may allow for cancer risk assessment that isn't confounded by EVs of non-prostate origin. In collaboration with Exosome Diagnostics, who are leaders in the field of EV based diagnostic tests, we propose an innovative multi-layer experiment to optimize and validate a reproducible protocol for PSMA enrichment and evaluate its utility for prostate cancer detection using RNAseq comprehensive profiling of well annotated urine samples from 250 men enrolled in a prostate cancer detection trial at U Miami.

PI_NAMEs: GASTON, SANDRA M;POLLACK, ALAN ;PUNNEN, SANOJ  (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Address;Aliquot;Antigens;artificial intelligence algorithm;assay development;Biological Assay;Biological Markers;biomarker discovery;Biopsy;Biopsy Specimen;Blood;Body Fluids;cancer biomarkers;cancer cell;Cancer Patient;cancer risk;Cessation of life;Clinical;clinical risk;clinical trial enrollment;Clinical Trials;clinically relevant;clinically significant;cohort;Collaborations;Collection;Data;Detection;detection limit;Development;Development Plans;Diagnosis;Diagnostic;Diagnostic tests;differential expression;Early Detection Research Network;Enrollment;Epitopes;Evaluation;exosome;experimental study;extracellular vesicles;FOLH1 gene;Foundations;Fright;Future;Genes;genetic signature;Goals;improved;Indolent;innovation;Institution;liquid biopsy;Liquid substance;Localized Malignant Neoplasm;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Membrane Lipids;Membrane Proteins;men;Messenger RNA;Methods;Molecular;molecular marker;novel;Oncogenes;Outcome;Parents;participant enrollment;Patients;Positioning Attribute;prediction algorithm;Preparation;Prostate;prostate biopsy;prostate cancer risk;Protocols documentation;pyrrolidin-3-yl-methanesulfonic acid;Reproducibility;Research;research and development;research clinical testing;Research Design;Risk;Risk Assessment;Risk Reduction;RNA;RNA marker;RNA Sequences;Sampling;screening;Screening for Prostate Cancer;Series;Source;Specificity;standard of care;Standardization;Structure of base of prostate;Surface Antigens;Testing;Tissues;Training;Transcript;transcriptome sequencing;tumor;Tumor Tissue;Untranslated RNA;urinary;Urine;Validation;vesicular release

PROJECT_TITLE: The Rigor and Clinical Utility of PSMA Enriched Extracellular Vesicles for Prostate Cancer Detection

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Pediatric;Prevention;Rare Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE This competitive renewal application aims to provide critical insight into the specific risk factors, developmental pathways, and consequences of anxiety in children with fragile X syndrome (FXS) in comparison to children with non-syndrome autism spectrum disorder (nsASD) and neurotypical development (NT). Following work initiated during the first funding period (2016-2023), characterization of the emergence, stability, and predictors of anxiety during preschool (3-7 years) will be extended to one timepoint during middle childhood (8-10 years), a critical developmental period when anxiety symptoms are likely to become more impairing and intervention is known to be most effective. This work will significantly inform targeted treatments that will improve the quality of life of individuals with neurodevelopmental disorders and their families.

PI_NAMEs: HOGAN, ABIGAIL LEE (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: 10 year old;Address;Adolescent;Adult;Affect;Anxiety;Anxiety Disorders;anxiety symptoms;Attention;autism spectrum disorder;Child;Childhood;childhood anxiety;clinical risk;cohort;critical developmental period;Data;Development;Developmental Course;Diagnosis;diagnostic criteria;Dimensions;Disease remission;early childhood;Early Diagnosis;Early identification;Early Intervention;Exhibits;Family;Female;Fragile X Syndrome;Functional impairment;Funding;high risk;Impairment;improved;Individual;innovation;insight;Intellectual functioning disability;interest;Intervention;Knowledge;Left;Longitudinal cohort;longitudinal dataset;male;meetings;Mental Depression;Mental Health;Methods;middle childhood;National Institute of Mental Health;Neurodevelopmental Disorder;Nursery Schools;Outcome;Paper;Pathological anxiety;Pathway interactions;Phenotype;Physiological;Predictive Factor;Prevalence;prospective;Quality of life;recruit;Regulation;Risk;Risk Factors;School-Age Population;Severities;Sex Differences;Specificity;Subgroup;Substance abuse problem;suicidal;Symptoms;Syndrome;Temperament;Work

PROJECT_TITLE: Emergence, stability, and predictors of anxiety in Fragile X syndrome

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Hematology;Mental Health;Neurosciences;Rare Diseases;Rehabilitation

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Our study aims to determine changes in cognition, functional independence, and health-related quality of life in older adults with acute myeloid leukemia following new venetoclax-based treatment. This knowledge can inform critical decision-making of older adults considering chemotherapy for this fatal disease.

PI_NAMEs: BHATT, VIJAYA RAJ (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Activities of Daily Living;Acute Myelocytic Leukemia;Adult;Aftercare;Age;Aging;Attention;attentional control;Auditory;BCL-2 Protein;Brain;cancer therapy;chemotherapy;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive process;cognitive reserve;comorbidity;comparison control;Data;Decision Making;Diagnosis;Disease;Disease remission;distraction;Dorsal;Education;Electroencephalography;Enrollment;European Organization for Research and Treatment of Cancer;Event;executive function;Exercise;frailty;functional decline;functional improvement;functional independence;Goals;health related quality of life;Hematologic Neoplasms;Impaired cognition;Impairment;improved;insight;instrumental activity of daily living;Interdisciplinary Study;Knowledge;leukemia;leukemia treatment;Longitudinal cohort study;Measures;Methods;multiple chronic conditions;neuroprotection;Neuropsychological Tests;Neurosciences;Newly Diagnosed;novel;novel strategies;novel therapeutic intervention;older adult;Oncologist;Outcome;Participant;Patients;Physical Function;physical impairment;Quality of life;Questionnaires;Recommendation;Research;Risk;Risk Factors;Scientist;sex;shared decision making;Short-Term Memory;success;Time;Visual

PROJECT_TITLE: Aging trajectories and outcomes of older adults with acute myeloid leukemia

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: ES

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Asthma;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative Rodent exposure can trigger asthma, a common disease of urban children. The present proposal will increase our understanding of how children are exposed to rats and the impact rat population dynamics may have on pediatric asthma severity. This research will open novel data-driven primary prevention strategies that can be tested to reduce pediatric exposure to rodents and the allergens they produce in and around the urban home and school environment.

PI_NAMEs: ROSENBAUM, MARIEKE HILARIDES (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Age;Allergens;Allergic;Allergic Disease;Asthma;Award;Binding;Binding Proteins;Boston;career;career development;Child;Childhood;Childhood Asthma;Chronic Disease;Cities;clinical investigation;Clinical Research;clinical translation;Clinical Trials;cohort;Collaborations;Commerce;Communities;community engagement;Data;data to knowledge;density;design;Disease;Doctor of Philosophy;Ecology;educational atmosphere;Enrollment;Environment;environmental allergen;Environmental Health;Epidemiology;Exposure to;Faculty;Funding;Goals;Health;Home;Home environment;Hospitalization;House Dust;House mice;Housing;Human;IgE;Incidence;indexing;Individual;inner city;Institution;interest;Intervention;Intervention Trial;Investigation;Learning;Measures;Mediating;Medical;Mentors;Modeling;Morbidity - disease rate;mouse allergen;Mus;National Heart, Lung, and Blood Institute;National Institute of Environmental Health Sciences;novel;particle;Patient Self-Report;Pheromone;Play;Population Dynamics;Prevention Measures;Prevention strategy;preventive intervention;primary outcome;Primary Prevention;Prospective cohort;Protein Secretion;Public Health;Rattus;Recording of previous events;Research;Resources;Restaurants;Rodent;Role;Sampling;school environment;Schools;Scientist;Services;Severities;skills;Sleep;sociodemographic variables;Statistical Methods;statistics;Techniques;Testing;therapy design;Time;Training;Training Programs;Translational Research;Translations;trial design;United States National Institutes of Health;Universities;urban children;urban school;urban setting;Urine;Veterinarians;Veterinary Medicine;Visit;Wild Animals;Work;Youth

PROJECT_TITLE: Urban rat exposure and pediatric asthma


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Mental Health;Neurosciences;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN MILWAUKEE

ORG_STATE: WI

PHR: Project Narrative: Memory impairments are characteristic of many neurological disorders, yet the development of effective treat- ments to reduce these deficits is hampered by our relatively rudimentary knowledge about the neural mecha- nisms through which memories are formed in males and females. The proposed research is relevant to public health because it will fundamentally advance our understanding of the neural mechanisms underlying hormo- nal regulation of memory formation in males and females, which will provide sorely needed insights that could lead to the generation of novel therapies specifically tailored to reduce memory dysfunction in patients of each sex. As such, the proposed research is particularly relevant to the mission of NINDS to use fundamental knowledge about the brain and nervous system to reduce the burden of neurological disease for all people.

PI_NAMEs: FRICK, KARYN M (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: 26S proteasome;Actins;Address;Adult;Alzheimer's Disease;Anxiety Disorders;Automobile Driving;behavioral outcome;Brain;calmodulin-dependent protein kinase II;Characteristics;Complex;Data;Dendritic Spines;density;Development;Dorsal;effective therapy;Estradiol;Estrogen Receptors;estrogenic;Etiology;Female;Functional disorder;Generations;Glutamate Receptor;Goals;Gonadal Steroid Hormones;Hippocampus;hormone regulation;in vivo;innovation;insight;Ion Channel;Knowledge;male;Mass Spectrum Analysis;Measures;Mediating;Memory;memory consolidation;Memory impairment;men;Mental Depression;Mental disorders;Mission;Molecular;multicatalytic endopeptidase complex;Mus;National Institute of Neurological Disorders and Stroke;Nervous System;Nervous System Disorder;neuromechanism;Neurons;neuropsychiatric disorder;neuropsychiatry;novel;novel therapeutics;Nuclear;Outcome;Pathway Analysis;Patients;Persons;pharmacologic;Pharmacology;Play;polymerization;Polymers;Polyubiquitination;Proteasome Inhibition;Protein Biosynthesis;protein degradation;Proteins;Proteomics;Public Health;Publishing;receptor;Regulation;Report (document);Research;Rodent;Role;sex;Sex Differences;Signal Transduction;Slice;Synapses;Synaptic plasticity;System;Testing;Tissues;Ubiquitin;ubiquitin mediated proteasome degradation;Vertebral column;Woman;Work

PROJECT_TITLE: Estrogenic regulation of the hippocampal ubiquitin-proteasome system and its role in memory and structural plastcity

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative The emergence of antiretroviral drug resistance has hindered progress toward combatting the ongoing HIV/AIDS epidemic. HIV-1 capsid (CA) is a promising, newly exploited target for drug development because it is a genetically fragile protein that has essential roles throughout the viral replication cycle. This project provides novel insight into yet another proposed role of CA in the evasion of innate immune sensing.

PI_NAMEs: ESCHBACH, JENNA  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Anti-Retroviral Agents;Anti-retroviral drug resistance;Anti-viral Response;antiretroviral therapy;Biology;Capsid;Capsid Proteins;Cell Fractionation;Cells;chemokine;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Complex;crosslink;cytokine;Cytoplasm;Cytosol;Degradation Pathway;Development;Dissociation;drug action;drug development;Drug resistance;Drug Targeting;Enzymes;Epidemic;experimental study;gag Gene Products;Genes;Genome;genomic RNA;HIV-1;HIV-1 integrase;HIV/AIDS;Host Defense Mechanism;Immune;Immunoprecipitation;Infection;Inflammatory;Innate Immune Response;innate immune sensing;insight;Integrase;Interferons;knock-down;Knock-out;Mediating;monocyte;multicatalytic endopeptidase complex;mutant;Mutation;novel;novel therapeutics;Nuclear;Nucleic Acids;Outcome;particle;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Play;premature;prevent;Process;Proteins;receptor;Regimen;Reporting;response;Reverse Transcriptase Polymerase Chain Reaction;Reverse Transcription;Ribonucleoproteins;RNA;RNA Binding;RNA Degradation;Role;sensor;Small Interfering RNA;success;targeted treatment;Toll-like receptors;Vaccines;Viral;Viral Genome;viral genomics;Viral Proteins;viral RNA;Virion;Virus;Virus Replication

PROJECT_TITLE: Role of HIV-1 capsid in innate sensing of viral nucleic acids

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-K(20)]


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Systemic lupus erythematosus (SLE) is an incurable chronic autoimmune disease that is characterized by multiorgan inflammation and presents with a wide range of symptoms, ranging from mild to life-threatening. Genome-wide association studies (GWAS) have implicated a number of single-nucleotide polymorphisms (SNPs) with disease, including many that colocalize with long non-coding RNAs (lncRNAs). In the current study, we propose to characterize a novel SLE-associated lncRNA (lnc12) and determine how it might contribute to the pathogenesis of SLE.

PI_NAMEs: TIAN, RUXIAO  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;Address;Affect;Alleles;Alternative Splicing;Animal Model;Anti-sense RNA;Antinuclear Antibodies;Autoantigens;autoreactive B cell;B-Cell Activation;B-Cell Development;B-Lymphocytes;Binding;Biological Markers;Body Weight Changes;Cell Culture Techniques;Cell Line;chronic autoimmune disease;chronic graft versus host disease;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complementary DNA;Complex;conditional knockout;Coupled;CRISPR/Cas technology;cytokine;design;Development;Disease;disease model;Disease Progression;DNA sequencing;Dominant-Negative Mutation;drug development;Drug Targeting;Enzyme-Linked Immunosorbent Assay;Etiology;Exons;experience;Family;Flare;Flow Cytometry;Gene Expression;Genes;genetic risk factor;Genetic Transcription;genome wide association study;genomic locus;Haplotypes;Histology;Human;Immune system;Immunoprecipitation;improved;in vivo;Infiltration;Inflammation;Inflammatory;Investigation;Investments;Island;knock-down;Knockout Mice;Knowledge;Life;Link;lymphoblastoid cell line;Maps;Mass Spectrum Analysis;Mature B-Lymphocyte;Mediating;member;Messenger RNA;Molecular Probes;Monitor;mortality;mouse model;Mus;Names;new therapeutic target;novel;Organ;overexpression;Pathogenesis;Patients;peripheral blood;Physiological;Plasma Cells;Population;Predisposition;Production;promoter;Protein Isoforms;Proteins;Raji Cell;recruit;Regulation;Regulatory Element;Reporting;Repression;Research;Risk;RNA;RNA Splicing;Role;Single Nucleotide Polymorphism;Single-Stranded DNA;Site;Small Interfering RNA;Spliceosomes;Structure of germinal center of lymph node;Symptoms;Systemic Lupus Erythematosus;Therapeutic;Tissue-Specific Gene Expression;Transcript;transcription factor;Transcriptional Regulation;Untranslated RNA;Variant;Western Blotting;Zinc Fingers

PROJECT_TITLE: A Novel Long Noncoding RNA Associated with Systemic Lupus Erythematosus Pathogenesis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Unexpected omission of rewards elicits an aversive internal state that is highly conserved across mammalian species, and has been associated with the onset and maintenance of anxiety disorders and depression, and reduced social interaction in humans. Our behavioral paradigm combined with in vivo and in vitro neuronal recordings and circuit activity manipulations will lead to a better understanding of how the brain computes dynamic modifications in reward availability to generate distinct patterns of behavior.

PI_NAMEs: BEIERLEIN, MICHAEL ;DO MONTE, FABRICIO HOFFMANN (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Amygdaloid structure;Animal Behavior;Animals;Anterior;Anxiety Disorders;Area;Attenuated;attenuation;Behavior;Behavioral;Behavioral Paradigm;behavioral response;Brain;Cell Nucleus;Conditioned Stimulus;Conflict (Psychology);Cues;Desire for food;Detection;Dopamine;dopaminergic neuron;Electrophysiology (science);emotion regulation;emotional distress;experimental study;Exposure to;Extinction;Food;Frequencies;Frustration;gain of function;genetic manipulation;Glutamates;Human;In Vitro;in vivo;insight;Laboratory Rat;Lead;loss of function;Maintenance;Mediating;Mental Depression;Modification;Motivation;Movement;negative affect;neural;neural circuit;neuronal circuitry;Neurons;Nucleus Accumbens;optogenetics;Organism;Outcome;Partner in relationship;Pathway interactions;Pattern;Phase;photoactivation;Population;Predictive Value;Prefrontal Cortex;pressure;Property;Rattus;response;Rewards;Role;Sensory;Shelter facility;Signal Transduction;Slice;Social Interaction;Structure;Structure of paraventricular nucleus of thalamus;Sucrose;Synapses;Synaptic plasticity;Testing;Thalamic structure;Training;Update;Ventral Tegmental Area;Water

PROJECT_TITLE: Corticothalamic circuits mediating behavioral adaptations to unexpected reward omission

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE LKB1 is one of the most frequently mutated genes in lung cancer; however, there are no effective therapies for patients with this disease. The frequency of LKB1 somatic mutation is significantly lower in female patients suggesting that the immune system in some females may be able to control this disease. This application aims to identify the underlying mechanism to develop novel therapeutic options for LKB1-mutant lung cancer.

PI_NAMEs: ZHOU, WEI  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: adaptive immunity;Adoptive Transfer;Animals;Antibodies;Antigen Presentation;Biological Assay;Cancer cell line;Cancer Model;cell killing;Cell Line;Cell Therapy;Cells;Characteristics;Data;Data Set;Development;dimensional analysis;Disease;disorder control;disorder subtype;DNA Adducts;effective therapy;Exposure to;Female;Foundations;Frequencies;Genes;Genetically Engineered Mouse;Goals;Histocompatibility Antigens Class I;Human;Immune;immune checkpoint blockade;Immune system;In Vitro;in vivo;Incidence;Injections;innate immune mechanisms;Innate Immune System;insight;interest;KRASG12D;Lung;Lung Adenocarcinoma;lung cancer cell;lung development;male;Malignant neoplasm of lung;Mediating;Meta-Analysis;Metastatic Neoplasm to the Lung;MHC Class I Genes;Modeling;Molecular;molecular targeted therapies;mouse model;Mus;mutant;Mutate;Mutation;Natural Immunity;Natural Killer Cells;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Patients;Predisposition;prevent;Regulation;Resistance;SCID Mice;sex;Sex Bias;Smoking;Somatic Mutation;STK11 gene;Structure of parenchyma of lung;Subgroup;Tail;targeted treatment;The Cancer Genome Atlas;trend;tumor;Tumor Antigens;tumor microenvironment;Tumor Suppressor Proteins;Veins;women patients;Work;X Inactivation

PROJECT_TITLE: Targeting LKB1-null lung adenocarcinoma with innate immune system

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_STATE: OH

PHR: PROJECT NARRATIVE Mantle cell lymphoma (MCL) is a blood cancer with a poor prognosis; thus, novel therapies are needed to cure these patients. The proposed study examines the role of FGFR1 in the biology of MCL and develops therapeutic strategies to treat MCL patients and improve overall outcomes.

PI_NAMEs: SEHGAL, LALIT  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Ablation;angiogenesis;Biological;Biology;Biopsy;c-myc Genes;carcinogenesis;CDC2 gene;CDKN1C gene;Cell Cycle;Cell Cycle Arrest;Cell Death;Cell Line;Cell Survival;Chemoresistance;Clinic;Clinical;clinical decision-making;clinical efficacy;clinically significant;cohort;Combined Modality Therapy;Data;Development;Dose;E2F transcription factors;EZH2 gene;Feedback;Fibroblast Growth Factor Receptor 1;Fibroblast Growth Factor Receptors;Gene Expression;Genes;Genetic;Genetically Engineered Mouse;Goals;Hematopoietic Neoplasms;Homologous Gene;improved;improved outcome;In Vitro;in vivo;inhibitor;Investigation;Knowledge;Lymphoma cell;Mantle Cell Lymphoma;Mediating;Membrane;Methods;migration;Molecular;mouse model;Non-Hodgkin's Lymphoma;novel;novel therapeutic intervention;novel therapeutics;Outcome;outcome prediction;overexpression;Pathway interactions;patient derived xenograft model;patient population;Patients;pharmacologic;Physiological;Play;pre-clinical;pre-clinical assessment;Pre-Clinical Model;preclinical study;preclinical trial;prevent;Process;Prognosis;programs;Progression-Free Survivals;Proteins;Receptor Protein-Tyrosine Kinases;Refractory;Relapse;Resistance;response;Role;Sampling;Schedule;Signal Pathway;Signal Transduction;small molecule;synergism;targeted treatment;Therapeutic;therapeutic target;Tissues;TK1 gene;Toxic effect;Transactivation;Translating;tumor;Up-Regulation;virtual

PROJECT_TITLE: Developing novel therapy to improve outcomes in MCL

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness;Social Determinants of Health

PHR: NARRATIVE Impairments in self and interpersonal functioning originate in early childhood and define Borderline Personality Disorder (BPD), yet we know little about how these constructs develop and interact across childhood and adolescence. This renewal will leverage 17 years of previously collected longitudinal data (R01 MH090786) to study the developmental origins of interpersonal and self dysfunction leading to BPD compared with MDD; combining this longitudinal data with newly collected observational, clinical, and personality indices during young adulthood. Results will have immediate implications for identifying risk trajectories unique to BPD onset, as opposed to homotypic continuity of MDD, starting at the earliest developmental points to inform the optimal timing and type of novel early-intervention targets for this strikingly impairing presentation.

PI_NAMEs: GILBERT, KIRSTEN ;WHALEN, DIANA J (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;Aggressive behavior;Amygdaloid structure;Behavioral;Borderline Personality Disorder;Child;Child Rearing;Childhood;Chronically Ill;Clinical;clinically significant;Conflict (Psychology);cost effective;Data;Data Collection;Data Set;design;Development;Diagnostic;disability;disabled;Disease;early childhood;Early Intervention;early onset;Electroencephalography;emerging adult;emotion dysregulation;Environmental Risk Factor;Event;Event-Related Potentials;Exhibits;Face;Functional disorder;Functional Magnetic Resonance Imaging;Funding;General Population;Impairment;indexing;Individual;intervention cost;Interview;Lead;Life;Link;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Major Depressive Disorder;Measures;Mediating;Mental disorders;Methods;middle childhood;mortality;National Institute of Mental Health;neural;neural circuit;neural correlate;novel;Nursery Schools;Onset of illness;Parents;Pathway interactions;peer;Perception;Personality;Personality Disorders;Phenotype;Poverty;prevent;Prevention strategy;Process;prospective;Psychopathology;Questionnaires;Reporting;Research;Research Domain Criteria;response;Rest;Risk;Risk Factors;Role;Sampling;Self Concept;social;Social Processes;Stimulus;suicide rate;Symptoms;System;Testing;Underemployment;Vent;young adult;Youth

PROJECT_TITLE: Developmental Pathways to Borderline Personality Disorder: Longitudinal Observational, Clinical, and Neural Predictors From Early Childhood to Young Adulthood

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-P(02)M]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Duchenne/ Becker Muscular Dystrophy;Muscular Dystrophy;Pediatric;Rare Diseases;Regenerative Medicine

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Failed regeneration and progressive muscle fibrosis are major pathological features of the muscular dystrophies (MDs), ultimately resulting in the replacement of functional musculature with a non-contractile fibro-matrix. Investigation into the cellular mechanisms contributing towards the development of muscle fibrosis has identified NAD(P)H oxidase 4 (NOX4) as an effective anti-fibrotic and pro-regenerative target in a severe mouse model of Duchenne MD. This project aims to investigate the mechanisms responsible for NOX4-associated muscle remodeling in efforts to identify potential translational strategies to combat the fibrotic replacement of muscle associated with the MDs.

PI_NAMEs: HAMMERS, DAVID W (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Ablation;Affect;Behavior;Biological Assay;Biological Models;cell behavior;Cell secretion;Cell Separation;cell type;Cells;Chronic;Clinical;Collaborations;combat;Cues;Data;Deposition;Development;Disease;Disease Progression;Duchenne muscular dystrophy;efficacious treatment;Exhibits;experimental study;Extracellular Matrix;Fatty acid glycerol esters;Fibrosis;Foundations;Future;Gene Expression;Genetic;Genetic Models;Goals;Heritability;Imaging Techniques;Immune;Immunologics;Impairment;improved;In Vitro;in vitro Assay;in vitro Model;in vivo;Inflammation;innovation;insight;Investigation;Label;Maps;Methodology;Modeling;Motility;mouse model;Muscle;Muscle Development;muscle form;muscle regeneration;Muscle satellite cell;Muscular Atrophy;Muscular Dystrophies;Myofibroblast;Myopathy;Natural regeneration;Neuromuscular Diseases;Oxidases;Pathologic;Pathology;Patients;Pattern;pharmacologic;Phenotype;Population;Prevalence;prevent;Process;Publishing;regenerative;Regenerative capacity;Regulation;Rejuvenation;Research;Role;Skeletal Muscle;Solid;Source;Testing;Therapeutic;therapeutically effective;tissue injury;Tissues;transcriptomics;translational approach;translational potential;treatment strategy;Work

PROJECT_TITLE: Understanding the Mechanisms of Fibrosis in Muscular Dystrophies

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ORG_DEPT: NEUROLOGY

PHR: Project narrative Nearly 75 percent of all strokes occur in people over the age of 65, indicating that stroke is definitely an age-related neurodegenerative disorder. We identified a gene, Ifi27l2a, that is significantly increased in the brain of the mouse and humans after stroke. Since our data suggests that Ifi27l2a contributes to deleterious microglial function, we now propose to test the effectiveness of reducing microglial Ifi27l2a expression as a strategy to limit brain inflammation, vascular dysfunction, and overall stroke pathology.

PI_NAMEs: KIM, GAB SEOK  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Adult;Affect;age related neurodegeneration;aged;Aging;aging brain;Anti-Inflammatory Agents;Attenuated;attenuation;Automobile Driving;Binding;Blood - brain barrier anatomy;blood-brain barrier disruption;Brain;brain cell;brain endothelial cell;Brain Injuries;Brain Ischemia;cell type;Cells;cytokine;Data;Disease;effectiveness testing;Encephalitis;extracellular;Female;Foundations;functional outcomes;Gene Dosage;Genes;glial activation;Gliosis;Hemorrhage;Human;human old age (65+);Immune;immune cell infiltrate;improved outcome;In Vitro;in vivo;Infarction;Inflammation;Inflammatory;Inflammatory Response;Injury;Interferon alpha;ischemic injury;Ischemic Stroke;knock-down;Knockout Mice;Long term disability;male;Mass Spectrum Analysis;Matrix Metalloproteinases;Microglia;Molecular;Morphology;Mus;neuroinflammation;Neurons;new therapeutic target;novel;novel strategies;Nuclear Receptors;old mice;Older Population;Outcome;overexpression;Pathology;Persons;Phagocytosis;Play;post stroke;Primary Cell Cultures;Production;progenitor;Protein Isoforms;Proteins;Proteomics;Reactive Oxygen Species;Recombinant Proteins;Recovery;Regulation;repaired;Role;Sampling;senescence;sex;sexual dimorphism;Signal Transduction;single-cell RNA sequencing;small hairpin RNA;Stroke;stroke model;stroke patient;stroke therapy;Testing;Therapeutic;therapeutic target;transcriptomics;Up-Regulation;Vascular Diseases;Viral

PROJECT_TITLE: Ifi27l2a as a therapeutic target for stroke

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Aortic disease is an important contributor to cardiovascular morbidity and sudden death. Key discoveries, including identification of the causal gene for Marfan’s syndrome (FBN1), have advanced our knowledge of syndromic aneurysm and dissection, but to date there remains little information about the genetic basis for sporadic thoracic aortic disease. This proposal aims to expand our understanding of the genetic basis for variation in the properties of the aorta, and to use those factors to predict who may be at high risk of developing clinical aortic disease.

PI_NAMEs: PIRRUCCELLO, JAMES  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: abdominal aorta;Advisory Committees;Aneurysm;Aorta;Aortic Aneurysm;Aortic Diseases;Architecture;ascending aorta;Award;biobank;Cardiology;Cardiovascular Diseases;Cardiovascular system;career;causal variant;Cementation;Cholesterol;Clinical;clinical risk;clinical training;clinically relevant;cohort;college;Complication;computer science;Computer software;Computer Vision Systems;Custom;Data;Dedications;deep learning;deep learning model;Developed Countries;Development;Diameter;Dilatation - action;Disease Outcome;Dissection;Educational process of instructing;Evaluation;exome sequencing;experience;Faculty;FBN1;Fellowship;General Hospitals;Genes;Genetic;genetic analysis;Genetic Risk;genetic risk factor;genetic variant;Genetic Variation;genome wide association study;genome-wide;genomic locus;Goals;high risk;human data;Human Genetics;Image;Individual;insight;interest;Knowledge;Learning;Life;Link;Machine Learning;Magnetic Resonance Imaging;Manuals;Manuscripts;Marfan Syndrome;Massachusetts;Measurement;Measures;medical schools;Mentors;Mentorship;Modeling;Molecular;Morbidity - disease rate;Nature;new therapeutic target;Operative Surgical Procedures;Participant;Pathologic;Peer Review;Persons;Phenotype;Play;Positioning Attribute;Preventive therapy;Property;Publishing;rare variant;Research;Research Personnel;Research Training;Risk;Risk Factors;Role;screening guidelines;skills;Software Engineering;Students;Sudden Death;Testing;therapeutic target;Thoracic aorta;Training;trait;university student;Variant;Work

PROJECT_TITLE: Deep learning to enable the genetic analysis of aorta

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Rare Diseases;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: INFECTIOUS DISEASES INSTITUTE

PHR: PROJECT NARRATIVE Men who engage in sexual relations with other men (MSM) are disproportionately affected by HIV and syphilis. The World Health Organization recommends dual HIV/syphilis rapid testing to reduce undiagnosed and untreated infections among MSM, but stigma and discrimination hinder uptake of facility-based testing. Peer-delivered HIV and syphilis self-tests, coupled with partner services, is an empowering, innovative approach that could circumvent healthcare stigma, substantially increase testing uptake and prevention coverage among MSM in Uganda, and help achieve national and global HIV 95:95:95 targets.

PI_NAMEs: OKOBOI, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Adult;Advocate;Affect;Africa South of the Sahara;aged;AIDS prevention;antiretroviral therapy;arm;Award;Behavior;Behavioral Sciences;Budgets;career development;Caring;civil society;Client;Clinic;Clinical Trials Design;Collaborations;Communicable Diseases;condoms;cost;cost effective;cost effectiveness;cost estimate;Counseling;Coupled;Data;design;Development Plans;Diagnosis;Discipline of Nursing;Discrimination;Disease Progression;economic evaluation;Effectiveness;effectiveness evaluation;empowerment;Epidemiology;Evaluation;Friends;General Population;global health;Goals;Grant;Guidelines;Head;Health;Health care facility;Health Care Sector;health care settings;health economics;Health Personnel;Health Services Accessibility;Healthcare;HIV;Human immunodeficiency virus test;human subject protection;improved;Incidence;Infection;Influentials;innovation;Intervention;intervention delivery;Interview;Joints;Letters;Link;Literature;male;men;men who have sex with men;Mentors;Methods;microcosting;Modeling;multidisciplinary;Newly Diagnosed;Observational epidemiology;Partner Notification;peer;peer influence;peer support;performance tests;Persons;pilot test;Positioning Attribute;Postdoctoral Fellow;pre-exposure prophylaxis;Prevalence;Prevention;Prevention Research;Preventive;primary outcome;Process;Productivity;psychosocial;Randomized;randomized trial;rapid testing;Recommendation;Research;Research Personnel;Research Training;Respondent;Risk;Route;Sampling;self testing;Service delivery model;Services;Sexual Partners;sexual risk behavior;Sexually Transmitted Diseases;skills;Social Network;social stigma;standard of care;Supervision;Syphilis;Syphilis Serodiagnosis;Testing;testing services;testing uptake;Training;transmission process;treatment arm;Uganda;Universities;uptake;Work;World Health Organization;Zimbabwe

PROJECT_TITLE: Peer delivered HIV/syphilis self-testing with assisted partner notification services for men who have sex with men (MSM) in Uganda


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: This study will provide a rigorous, computational foundation for describing the functional organization of higher-order auditory cortex at high spatial (single-unit) and temporal (500 Hz) resolution. Such a description is necessary for understanding and, ultimately, ameliorating hearing disorders with cortical origins. We also expect it to enable the design of more effective hearing aids, including novel applications of ANNs to assistive hearing devices.

PI_NAMEs: MAKIN, JOSEPH GERARD;RECANZONE, GREGG HOWARD (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Active Listening;Animals;area V4;artificial neural network;Auditory;Auditory area;auditory discrimination;auditory stimulus;Auditory system;Back;Biological Neural Networks;biophysical model;Brain;Classification;Complex;Data;deep neural network;design;discrimination task;Electrophysiology (science);experimental study;Foundations;Frequencies;Hearing Aids;Hearing problem;Human;Image;Length;Location;Macaca;Macaca mulatta;Machine Learning;Measures;Methods;Modeling;Monkeys;Music;Nervous System;neural network architecture;Neurons;neurophysiology;novel;Performance;Play;preference;Primates;Protocols documentation;Resolution;response;Saimiri;Sensory;sound;Speech;Stimulus;Structure;System;Testing;Text;theories;Time;Training;ventral visual stream;Visual;Visual Cortex;Voice

PROJECT_TITLE: CRCNS: Identifying principles of auditory cortical organization with machine learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(50)R]


ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative Despite the vast knowledge of the structure and mechanical function of mature tendons, the understanding of tenogenic cell differentiation during development and how cell types from non-tenogenic origins, such as macrophages, influence tendon formation is limited. Tissue resident macrophages play key roles in the development of various tissues and colony stimulating factor 1 receptor (CSF1R) signaling is essential for their differentiation and survival. This proposal aims to fill this gap in knowledge by defining the ontogeny, distribution, and phenotypic profile of tendon resident macrophages and establish their communication with tenocytes to regulate tendon growth and development.

PI_NAMEs: DYMENT, NATHANIEL A. (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Ablation;Address;Adult;Affect;Age;age related changes;Biology;Cell Differentiation process;Cell Lineage;cell type;Cells;Cellular biology;Clinical;Coculture Techniques;Collagen;Communication;CSF1 gene;Data;Development;Embryo;Endothelial Cells;Extracellular Matrix;Fascicle;Fibroblasts;Flow Cytometry;Future;Growth;Growth and Development function;Growth Factor;Homeostasis;Impairment;improved;In Situ;insight;Knowledge;Label;Ligands;Macrophage;Macrophage Colony-Stimulating Factor;Macrophage Colony-Stimulating Factor Receptor;Maintenance;Mechanics;Messenger RNA;Mus;Neurons;novel;Osteoblasts;Outcome;Pattern;Phenotype;Play;Population;Positioning Attribute;postnatal;Proliferating;PTPNS1 gene;Qualifying;Receptor Signaling;regenerative approach;repaired;Reporting;Role;Signal Transduction;single-cell RNA sequencing;Source;Spatial Distribution;spatiotemporal;Stains;Structure;tendon development;Tendon structure;Testing;Time;Tissues;Yolk Sac

PROJECT_TITLE: Coordinated resident macrophage-tenocyte signaling in tendon formation

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE HIV PEP is underutilized and understudied in the current HIV epidemic. The long-term goal of this work is to develop, refine, and validate a technology-delivered decision aid to assist providers and patients in understanding and using HIV PEP in their practice and lives. Improving HIV PEP implementation and understanding can improve care and outcomes for a highly marginalized group of people at risk for HIV.

PI_NAMEs: ANDERSON, JOCELYN CHRISTINE (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Accountability;Acquired Immunodeficiency Syndrome;Acute;Adherence;Adopted;Age;Anti-Retroviral Agents;Area;Caring;case-by-case basis;Centers for Disease Control and Prevention (U.S.);Clinical;clinical practice;cognitive interview;Communities;community advisory board;Complex;Conflict (Psychology);Confusion;cost;cost effectiveness;cost estimate;Cost Savings;Data;Decision Aid;Decision Making;design;Development;digital;District of Columbia;Education;Effectiveness;efficacy testing;Emotional;Epidemic;Equity;evidence base;experience;Exposure to;Feedback;Financial Hardship;follow-up;Forensic Medicine;Future;Goals;Health behavior;Health Personnel;high risk;HIV;HIV risk;HIV Seropositivity;Hour;improved;Inequity;International;internet delivery;Intervention;intravenous drug use;Justice;Knowledge;life time cost;marginalization;marginalized population;Measures;Medical;Methods;Multimedia;Nurses;Outcome;Output;Patient Care;patient engagement;patient-clinician communication;Patients;Pattern;Perception;perpetrators;Personal Satisfaction;Persons;Pharmaceutical Preparations;pill;Populations at Risk;prevent;Prevention Guidelines;Privacy;Process;programs;Prophylactic treatment;prototype;Provider;provider behavior;provider communication;Qualifying;Race;Recommendation;Regimen;Relationship-Building;Reporting;response;Risk;risk perception;risk sharing;Science;seroconversion;sexual assault;side effect;social stigma;Social support;Source;Standardization;Surveys;Technology;Testing;theories;therapy development;tool;Translating;transmission process;Unsafe Sex;Variant;Viral;Work;World Health Organization

PROJECT_TITLE: Development of a patient-provider decision aid for HIV post-exposure prophylaxis

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: A protein that is known to be involved in Alzheimer’s, Parkinson’s (AD/PD) as well as other neuronal diseases is CRMP which alongside Fyn/Lyn-, Cdk5- and GSK3β-Kinase becomes hyper-phosphorylated and forms a complex with these kinases and, as we for the first time show here, Eph family family members interact with CRMP. The regions of the Eph intracellular region as well as of CRMP which are phosphorylated by the Alzheimer disease associated kinase, Lyn, are currently unknown, but will be delineated- together with the interaction interfaces involved in the proposed project. In future, the derived knowledge will be used to generate a diagnostic antibody or peptide-based agent that detects early processes in the development of AD neuronal disease.

PI_NAMEs: BUCK, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Actins;Affinity;aging brain;Alzheimer's Disease;Amyloid beta-Protein;Antibodies;antibody diagnostic;Antigens;Binding;Biochemical;Bioinformatics;biophysical techniques;Biophysics;Brain;C-terminal;Cardiovascular system;cell motility;Cells;Complex;Computer Models;Cytoskeleton;Data;design;Development;Diagnostic;Disease;Docking;Early Diagnosis;Eph Family Receptors;experimental study;Exploratory/Developmental Grant;Family;Family member;follow-up;Future;Future Generations;glycogen synthase kinase 3 beta;Grain;Homologous Gene;In Vitro;insight;Knowledge;Learning;Link;Mammalian Cell;Mediator;Memory;Microtubules;mimetics;Molecular;molecular dynamics;molecular modeling;Mutagenesis;Mutation;Natural regeneration;Nature;Neurodegenerative Disorders;neuron development;Neuronal Injury;Neurons;Organism;Parkinson Disease;Pattern;Peptides;Phosphorylation;Phosphotransferases;plexin;potential biomarker;Preparation;Process;protein complex;Protein Kinase;protein purification;Proteins;reconstitution;Research;Research Personnel;response;Risk;Role;SAM Domain;Sampling;scaffold;Semaphorin-3A;Site;structural biology;Structure;System;targeted treatment;tau Proteins;Therapeutic;Therapeutic Intervention;Time;tool;Validation

PROJECT_TITLE: Eph and Lyn hyper-phosphorylation and CRMP interactions in AD"

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Prescription Drug Misuse;Prevention;Screening and Brief Intervention for Substance Misuse;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LONG BEACH

ORG_NAME: CALIFORNIA STATE UNIVERSITY LONG BEACH

PHR: PROJECT NARRATIVE Prescription stimulant misuse [PSM] and prescription stimulant diversion [PSD] are inter-related high-risk health behaviors prevalent on college campuses. College health providers [CHPs] can play a key role in identifying and intervening upon these behaviors, but have identified a lack of training in PSM and PSD as a barrier. As such, the proposed project seeks to engage CHPs in the refining and piloting of a newly developed screening and brief intervention curriculum to address both PSM and PSD, and to determine the impact of the intervention on student behavior.

PI_NAMEs: BAVARIAN, NILOOFAR  (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: Address;Adolescent;Adoption;Adult;adverse event risk;American;Attention deficit hyperactivity disorder;Behavior;behavior influence;brief intervention;college;Community Health;Dependence;design;Development;Directories;Disease;Educational Curriculum;Educational Intervention;Educational process of instructing;Eligibility Determination;Environmental Risk Factor;Evaluation;Face;feasibility testing;Feedback;follow-up;Funding;Future;Geography;Goals;Health;Health behavior;Health Personnel;Health Promotion;high risk;implementation barriers;implementation intervention;implementation strategy;insight;Institution;Intervention;Intervention Studies;Interview;Knowledge;Measures;member;Methods;Mission;Morbidity - disease rate;mortality;motivational enhancement therapy;National Institute of Drug Abuse;Nature;nonmedical use;novel;Online Systems;Outcome;Overdose;Participant;peer;pilot test;Play;Populations at Risk;prescription stimulants;prevent;Prevention;Process;Provider;Public Health;Randomized;recruit;Reporter;Research;Resolution;Risk;Running;Sampling;screening;screening and brief intervention;simulation;Stimulant;stimulant misuse;Students;substance use;Surveys;Techniques;Testing;theories;tool;Training;United States National Institutes of Health;Universities;university student;young adult

PROJECT_TITLE: Screening and Brief Intervention for Prescription Stimulant Misuse and Diversion: Refining and Piloting a Curriculum for College Health Providers

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Social Determinants of Health;Vaccine Related

ORG_CITY: FAJARA

ORG_COUNTRY: GAMBIA

ORG_FIPS: GA

ORG_NAME: MEDICAL RESEARCH COUNCIL UNIT THE GAMBIA AT THE LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE

PHR: The Immunization Agenda 2030 (IA2030) strategic focus on halving zero-dose children and eliminating measles transmission by 2030 requires spatially detailed data and methodological approaches to precisely locate un- and under-vaccinated subpopulations and forecast outbreaks. The overall goal of this project is to apply novel spatiotemporal modelling approaches to precisely map the subpopulation of children with zero- dose and untimely measles vaccination in The Gambia, examine potential links with suboptimal herd immunity and outbreak risk, and how geographic accessibility shapes vaccination uptake and delivery. This project will contribute to the achievement of the IA2030 in The Gambia and provide advanced training that will equip Dr Wariri with novel skills and competencies needed to acheive his long-term goal of developing an independently funded infectious diseases and spatial epidemiology research program in Africa.

PI_NAMEs: WARIRI, OGHENEBRUME  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TITLE: Investigating the contribution of geographic accessibility and vaccine delivery channels to untimely measles vaccination and zero-dose prevalence in The Gambia: implications for disease outbreaks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-J(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Rigorous research techniques are essential to addressing fundamental questions and challenges in modern neuroscience research. The proposed educational units will elevate competencies in the application of rigorous research principles across the research workforce, with a large potential impact in all areas of neuroscience research, including the nation’s biomedical, behavioral, and clinical research needs.

PI_NAMEs: EDEN, URI TZVI;KRAMER, MARK ALAN (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, DEVON CHRISTINE

PROJECT_TERMS: Active Learning;Address;Area;Automobile Driving;Behavioral Research;Biological;Biological Sciences;Biomedical Research;career;Case Study;Clinical Research;Collaborations;Communities;community center;Competence;complex data;computer code;computer program;cost;Data;Data Analyses;Data Storage and Retrieval;E-learning;Education;Education Projects;education research;educational atmosphere;Educational Models;Exercise;experience;Face;Familiarity;Feedback;Goals;hands-on learning;improved;Individual;insight;interest;Learning;learning materials;lectures;Mathematics;Measures;Modernization;Multimedia;Nervous System Disorder;neural;Neurons;neuropsychiatric disorder;Neurosciences;Neurosciences Research;personalized learning;pragmatic implementation;Psychologist;Pythons;Research;Research Personnel;Research Technics;Resources;skills;Students;Technology;temporal measurement;Text;Training;undergraduate student;Writing

PROJECT_TITLE: Rigorous Research Principles for Practicing Neuroscientists


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Pediatric;Prevention

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Glaucoma is a leading cause of blindness afflicting more than 60 million people worldwide and is linked to elevated pressure within the eye. We discovered the molecular building blocks (known as the Angiopoietin- Tie2/TEK pathway) needed to drain fluid from the eye to maintain a healthy, low pressure. We subsequently found gene mutations in this pathway cause severe glaucoma and blindness in children and increase risk of glaucoma in adults. In this proposal, we will characterize the role of two new glaucoma genes in this pathway and test effectiveness of a novel Angpt/TEK-targeted therapy to lower eye pressure, treat glaucoma and prevent blindness.

PI_NAMEs: JIN, JING ;QUAGGIN, SUSAN E. (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;Adult;Affect;Angiopoietins;ANGPT1 gene;ANGPT2 gene;Animal Model;anterior chamber;Aqueous Humor;Binding Sites;Biological Assay;Biomedical Engineering;Blindness;Blood Vessels;Cell Death;Cell Lineage;Cell Survival;cell type;Cells;Child;Childhood;Clinic;clinical development;cohort;Collaborations;Defect;design;Development;Disease;disease phenotype;disorder risk;Dose;effectiveness testing;Endothelial Cells;Endothelium;Eye;Failure;Family;functional restoration;Funding;Gene Expression;Gene Mutation;Genes;Genetic;genetic variant;Genomic Segment;Glaucoma;Grant;human disease;Hydrophthalmos;improved;Individual;insight;International;Lead;Ligands;limbal;Link;Liquid substance;loss of function;loss of function mutation;Maintenance;Maps;MicroRNAs;mimetics;Modeling;Molecular;Monkeys;mouse model;Mus;Mutation;novel;novel therapeutics;Ocular Hypertension;Open-Angle Glaucoma;Pathogenesis;Pathway interactions;Patients;Persons;Phenotype;Phosphoric Monoester Hydrolases;Physiologic Intraocular Pressure;Population;pressure;prevent;primary congenital glaucoma;Primary Open Angle Glaucoma;Receptor Protein-Tyrosine Kinases;repaired;Reporting;Resistance;Retinal Ganglion Cells;Risk;Risk Factors;Risk Reduction;risk variant;Rodent;Role;Seminal;Severities;Signal Pathway;Signal Transduction;single cell analysis;single-cell RNA sequencing;Structure;Structure of sinus venosus of sclera;targeted treatment;TEK gene;Testing;TIE-2 Receptor;Tissues;Trabecular meshwork structure;Variant;Work

PROJECT_TITLE: Activation of the Angiopoietin-Tie2/TEK Pathway to Treat Ocular Hypertension and Glaucoma

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Precision Medicine

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Yale Center for Clinical Investigation (YCCI) has been a leader and strong partner with other CTSA hubs in research democratization to diverse populations, enhancement of the electronic health record to promote translational science, and leveraging the broad expanse of Yale University's outstanding T1 to T4 multi-School scientific environment with the clinical strength of Yale New Haven Health System to create a learning health system that reaches into communities. YCCI will work with other CTSAs to foster the further growth of multidisciplinary team science, develop innovative collaborative precision-health based strategies for disease prevention, diagnostics, and therapeutics, and implement to obtain real-world beneficial results for the benefit of all populations in the learning health system.

PI_NAMEs: KRYSTAL, JOHN H.;OHNO-MACHADO, LUCILA ;SMITH, BRIAN RICHARD (contact)

PROGRAM_OFFICER_NAME: MERCHANT, CAROL

PROJECT_TERMS: Acceleration;actionable mutation;Address;Area;Beds;bioimaging;Bioinformatics;Biometry;career;career development;Catchment Area;Clinical;Clinical and Translational Science Awards;clinical care;clinical center;clinical investigation;Clinical Research;Collaborations;Communities;community based research;Connecticut;County;Data;data resource;Democracy;Diagnostic;disorder prevention;Education;Electronic Health Record;Environment;Ethics;exome sequencing;Faculty;Family;Fellowship Program;forging;Fostering;Functional disorder;Funding;Future;Generations;Genomics;Grant;Growth;Health;health care disparity;Health equity research;Health system;Healthcare;Healthcare Systems;Heart;Home;Hospitals;Image;Imprisonment;Improve Access;Industry;Informatics;informatics infrastructure;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;International;Investments;Learning;Link;member;Methodology;Mission;multidisciplinary;multiple omics;new technology;next generation;novel;Outpatients;patient population;Patients;personalized health care;personalized intervention;personalized medicine;Pilot Projects;point of care;Population;Population Heterogeneity;post-doctoral training;pre-doctoral;Precision Health;programs;Public Health;Public Health Informatics;Randomized;recruit;Reproducibility;Research;research and development;Research Infrastructure;Research Personnel;Research Support;Research Training;Resources;Rhode Island;Role;Scholars Program;Schools;Science;Scientific Advances and Accomplishments;Scientist;Shapes;Site;Special Population;Talents;Technology;Therapeutic;Training;Training Programs;translational impact;translational pipeline;Translational Research;translational scientist;Translations;United States National Institutes of Health;Universities;Visit;Wood material;Work

PROJECT_TITLE: Yale Clinical and Translational Science Award


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: Boulder

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: NARRATIVE The COVID-19 pandemic is fundamentally changing neighborhood landscapes and ways of aging in place. This research investigates how neighborhoods affect cognitive health among aging populations before and after the onset of the pandemic. Policymakers, service providers, community groups, older adults, and researchers may use project findings to advance age-friendly community efforts to help prevent cognitive decline and facilitate healthy aging in place.

PI_NAMEs: FINLAY, JESSICA MARIE (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Acute;Address;Adult;Aerobic;Affect;aged;Aging;aging in place;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Area;Businesses;career;career development;Coffee;Cognitive;Cognitive aging;cognitive function;Communities;Community Services;COVID-19;COVID-19 pandemic;COVID-19 survivors;Crowding;Data;data archive;dementia risk;design;Development;Disease Outbreaks;Elderly;Environment;experimental study;Fellowship;Foundations;Friends;Funding;Future;Geographic Locations;Gerontology;Goals;Health;Health and Retirement Study;Health Policy;Health Services;healthy aging;Impaired cognition;Impairment;Infrastructure;innovation;Intervention;Knowledge;late life;Libraries;Life;Link;Long-Term Care;longitudinal analysis;Measures;Mental Health;Mentors;Mentorship;Methods;Michigan;Modeling;Muscle Weakness;Museums;Neighborhoods;novel;older adult;Outcome;pandemic disease;Personal Satisfaction;Phase;Physical activity;Policy Maker;Population;population based;prevent;programs;protective factors;Public Health;Quality of life;Research;Research Methodology;Research Personnel;resilience;Resources;Risk;Risk Factors;risk mitigation;Risk Reduction;Sampling;service providers;Services;Shapes;skills;social;social determinants;Social Distance;social implication;Social Interaction;Social isolation;Socialization;Source;Training;Transportation;Trauma;Travel;Universities;walkability

PROJECT_TITLE: Aging in Place since the COVID-19 Pandemic Onset: A Study of Neighborhoods and Cognitive Health among Older Americans

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PI_NAMEs: PRABHAKARAN, VIVEK  (contact)

PROGRAM_OFFICER_NAME: GANNOT, GALLYA

PROJECT_TERMS: Academia;Active Learning;Address;Appointment;Area;Bioinformatics;Biotechnology;career;Clinical Research;cohort;Collaborations;Communication;Communities;Community Outreach;Competence;Development Plans;diversity and equity;Educational Curriculum;Entrepreneurship;Environment;Equity;externship;Faculty;Family;flexibility;Fostering;Funding;Goals;Government;Health;health equity;Health equity research;Individual;Industry;innovation;Leadership;Measures;Mentors;Mentorship;Methods;Midwestern United States;Modeling;Monitor;National Center for Advancing Translational Sciences;National Research Service Awards;Patients;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Productivity;programs;Reproducibility;Research;responsible research conduct;Scholars Program;Science;Self Efficacy;skills;success;Surveys;symposium;TNFSF15 gene;Training;training opportunity;Training Programs;Translational Research;Universities;Wisconsin;Work;Workforce Development

PROJECT_TITLE: NRSA Training Core


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PHR: This proposal is a competing renewal application to support the training of 10 pre-doctoral students enrolled in the PhD graduate neuroscience program at Emory University during years 1 or 2 of training. The interdisciplinary Emory neuroscience program currently comprises a total of 94 training faculty and 81 PhD students involved in neuroscience research that cuts across a wide array of disciplines that range from the understanding of basic neural communication to the treatment of complex neurological and psychiatric disorders. The dramatic growth of the applicant pool, combined with the large number of well-funded neuroscience faculty and excellent achievements of the current trainees in producing solid peer-reviewed publications, seeking external grants and developing highly successful research-related careers, serve as the main basis to justify the request of a raise in the number of slots supported by this training grant from 7 to 10 for the next funding period.

PI_NAMEs: SMITH, YOLAND  (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Biology;Neurosciences;System;Training

PROJECT_TITLE: Training In Systems And Integrative Biology Neuroscience


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE While pediatricians may suspect that Latinx children in immigrant families may have experienced trauma related to immigration, this trauma is not being captured in settings best equipped to identify and intervene to address this trauma, such as their primary care homes. The goal of this research is to build and test a trauma- informed care questionnaire in pediatric primary care that effectively screens for the unique traumatic experiences of Latinx children in immigrant families. The K23 award will also provide Dr. Martin with the time and training necessary for an independent research career in pediatric trauma-informed care and health equity.

PI_NAMEs: MARTIN, KEITH  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: acceptability and feasibility;Active Learning;Address;adverse childhood events;Adverse event;Awareness;Baltimore;Bass;bullying;Calibration;career;career development;Caring;Child;Child Care;Child Health;Child Support;Child Welfare;Childhood;Cities;class Musci;Classification;Clinic;clinical application;Clinical Informatics;cognitive interview;Computerized Medical Record;Consultations;Data;Development;Development Plans;Discrimination;early life adversity;effectiveness/implementation trial;Environment;evidence base;experience;Factor Analysis;Family member;Focus Groups;Funding;Generations;Goals;Grant;Health;health disparity;health equity;Healthcare;ideation;Immigrant;Immigrant family;Immigration;implementation outcomes;implementation science;imprint;improved;Information Systems;intergenerational;Intervention;K-Series Research Career Programs;Latinx;Latinx population;Manuscripts;Maryland;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;migration;National Institute of Child Health and Human Development;novel;Nurses;Outcome;Outcome Measure;Parents;Pathway interactions;patient home care;patient oriented;Patient Outcomes Assessments;Patients;pediatric trauma;pediatrician;Personal Satisfaction;Physicians;Population;Positioning Attribute;Practical Robust Implementation and Sustainability Model;pragmatic implementation;Prevention strategy;Primary Care;primary care clinic;primary care practice;primary care provider;Process;programs;Provider;Psychometrics;Questionnaires;Race;Recording of previous events;Refugees;Reporting;Research;research and development;Research Ethics;Research Personnel;response;responsible research conduct;Sampling;screening;Secondary Prevention;Signs and Symptoms;skills;Sorting;Strategic Planning;Stress;stressor;teacher;Techniques;tertiary prevention;Testing;theories;Time;Training;Trauma;trauma care;trauma centers;trauma exposure;trauma symptom;United States;Universities;Validation;Work;Writing

PROJECT_TITLE: MOSAICO: Modifying and Optimizing a Screener of Adverse Immigrant Childhood Occurrences for Trauma-Informed Care (TIC) in Pediatric Settings

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Pediatric;Prescription Drug Misuse;Social Determinants of Health;Substance Misuse

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

PHR: PROJECT NARRATIVE Non-medical of prescription opioids (NMUPO) in young adults is particularly concerning and is robustly influenced by psychosocial factors. Given the advantages of flexibility, wide coverage, and real-time responses/assessment, social media can be a promising and innovative approach to deliver psychosocial intervention to young adults but yet few theory-based social media interventions are available for NMUPO in this at-risk population. The proposed plan for research and career development addresses the critical gaps by theoretically exploring psychosocial contents associated with NMUPO among young adults via the formative assessment and using these findings to develop and pilot-test the feasibility and preliminary efficacy of a theory-based and peer-led social media intervention to reduce NMUPO and address psychosocial factors among young adults.

PI_NAMEs: TAM, CHEUK CHI  (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: addiction;Address;Adult;age group;aged;Behavioral;career development;Clinical Trials;Collaborations;college;coping;Coping Skills;Data;design;Development;Dose;drug misuse;Ecological momentary assessment;Environment;Evaluation;Expectancy;Exposure to;feasibility testing;Fentanyl;flexibility;formative assessment;Future;Goals;Health;Health Psychology;High Prevalence;high risk population;illicit drug use;improved;Individual;innovation;innovative technologies;insight;Instagram;Intervention;Interview;Link;Literature;Media Intervention;media use;Medicine;Mentors;Mentorship;Methodology;Methods;Modeling;Monitor;Motivation;Outcome;overdose death;Participant;peer;Peer Group;peer recovery;peer support;perceived stress;Persons;Pharmaceutical Preparations;pilot test;Population;Populations at Risk;post intervention;prescription opioid;prescription opioid misuse;primary outcome;Privatization;Productivity;programs;psychiatric symptom;psychosocial;Psychosocial Factor;Psychosocial Influences;Psychotherapy;Public Health;randomized controlled design;Randomized, Controlled Trials;Reaction Time;Recovery;recruit;Reporting;Research;research and development;Research Personnel;research study;resilience;Risk;Role;Schools;secondary outcome;Self Efficacy;skills;Social Development;social media;South Carolina;Structure;substance misuse;substance use;Substance Use Disorder;Supervision;Support Groups;Surveys;Techniques;Technology;temporal measurement;Testing;theories;Theory of Change;therapy design;therapy development;Time;tool;Training;Training Activity;United States;Universities;usability;virtual;Vulnerable Populations;young adult

PROJECT_TITLE: Theory-based social media intervention for non-medical use of prescription opioids (NMUPO) in young adults

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE This project aims to examine the role of dynamic emotion regulation processes (i.e., reactivity, regulation, and flexibility) at the behavioral and neurophysiological levels as a proximal indicator of psychopathology risk following exposure to traumatic stress (threat) in childhood. This proposal has both scientific and clinical significance, as there are few studies clarifying the contribution of cross-system regulatory processes in relation to threat and the emergence of psychopathology. This research has the potential to identify factors that inform when adolescents are at greatest risk for mental health spurred by stress vulnerability and to identify prescriptive targets for intervention during these periods.

PI_NAMEs: GRUHN, MEREDITH  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: acute stress;Address;Adolescence;Adolescent;Adrenal Glands;Age;aged;Amygdaloid structure;Area;Attention;Autonomic nervous system;base;Behavioral;Biological;biological adaptation to stress;Biological Markers;Biology;Childhood;childhood adversity;clinically significant;comorbidity;Data;design;Development;Diagnostic;Dimensions;Domestic Violence;emotion regulation;Emotions;Evaluation;Exposure to;flexibility;follow-up;Functional Magnetic Resonance Imaging;Goals;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Impairment;indexing;Intervention;Investigation;Laboratories;life span;Link;Literature;Measures;Mediating;Mediator;Mental Health;Methods;Modeling;Modification;Molecular;National Institute of Mental Health;Nature;neglect;neural;neural network;Neurobiology;neurophysiology;Participant;Pathology;Pathway interactions;Patients;Pattern;Physiological;Physiology;Pituitary Gland;Process;prospective;Psychopathology;psychosocial;recruit;Regulation;Research;Research Domain Criteria;Research Support;resilience;response;Risk;Risk Factors;Role;Sampling;Severities;Stress;stress reactivity;stressor;Symptoms;System;Testing;tool;traumatic stress;treatment response;Work;Youth

PROJECT_TITLE: The Impact of Adversity on Neurobiological and Psychosocial Dimensions of the Stress Response System

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Myelodysplastic syndromes (MDS) are defined by the hierarchical acquisition of genetic mutations in the bone marrow resulting in ineffective hematopoiesis and propensity to transform to acute myeloid leukemia (AML). This project seeks to determine the mechanisms by which inactivating mutations in BCOR, a recurrently mutated core component of the non-canonical polycomb repressive complex 1.1 (PRC1.1), interact with mutations in the RNA splicing factor U2AF1 to mediate MDS progression. The proposed research will advance our understanding of PRC1.1 dysfunction in hematopoiesis and myeloid malignancy development with the potential to improve surveillance and treatment strategies for MDS patients.

PI_NAMEs: VEDULA, RAHUL  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Acute Myelocytic Leukemia;Advisory Committees;Affect;Automobile Driving;Biological Process;Biology;Biometry;Bone Marrow;career;career development;Cell Compartmentation;Cell Line;Cells;Clinical;clinical practice;Clonal Expansion;Codon Nucleotides;cohort;Collaborations;Complex;Computational Biology;Dana-Farber Cancer Institute;Data;derepression;Development;Development Plans;Disease;Disease Progression;DNA Sequence Alteration;Dysmyelopoietic Syndromes;Engineering;Environment;Epigenetic Process;experimental study;EZH2 gene;FLT3 gene;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;genome-wide;Goals;Growth Factor;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic stem cells;improved;in vivo;Ineffective Hematopoiesis;insight;International;K562 Cells;leukemic transformation;leukemogenesis;Leukopenia;Link;Measurement;Mediating;Mentorship;Modeling;mouse model;Mus;mutant;mutant mouse model;Mutate;Mutation;Myelogenous;Myeloproliferative disease;novel therapeutic intervention;Oncogenic;Oncologist;Outcome;Output;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Physicians;Policies;Polycomb;PRC1 Protein;Principal Investigator;programs;Protein Isoforms;Recurrence;Repression;Research;RNA Splicing;Sampling;Scientist;Signal Transduction;SRSF2 gene;stem cell function;Stereotyping;surveillance strategy;synergism;Therapeutic;therapeutic target;Time;Training;transcriptomics;Translational Research;translational scientist;treatment strategy;Tropism;Variant;Work;Writing

PROJECT_TITLE: BCOR/PRC1.1 Inactivation In Splicing Factor Mutant MDS Progression

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]