NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: AUGUSTA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: The State of Georgia experiences significant cancer incidence and mortality disparities within its minority and underserved communities. Our Georgia CaRes NCI Community Oncology Research Program (NCORP) Minority/Underserved Site addresses these disparities by focusing on providing clinical trials, cancer control and prevention trials, and cancer care delivery research to Georgia's minority and underserved communities (rural, inner city). Renewal of Georgia CaRes will greatly impact the public health (especially with respect to cancer) of minority and underserved communities within the State of Georgia and beyond.

PI_NAMEs: GHAMANDE, SHARAD A. (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Address;Adolescent;Adult;African American;African American population;Age;anti-cancer research;base;Blood;cancer care;Cancer Center;Cancer Control;cancer health disparity;Cancer Patient;cancer prevention;Cancer Research Network;cancer therapy;care delivery;Catchment Area;Caucasians;Child;clinical trial enrollment;Clinical Trials;Collaborations;Collection;Colorectal Cancer;Committee Membership;Communities;Community Clinical Oncology Program;Community Networks;Community Outreach;control trial;Death Rate;design;Development;Discipline;Disparity;Disparity population;Documentation;Education;Elderly;Enrollment;Ensure;ethnic minority;Ethnic Origin;experience;Gender;Goals;Health Personnel;Healthcare;Home;Hospitals;Human;imaging study;improved;Incidence;inner city;interest;Leadership;Location;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical center;medically underserved population;member;Minority;minority communities;Minority Groups;minority health;Mississippi;Morbidity - disease rate;Morehouse School of Medicine;mortality;mortality disparity;Names;National Clinical Trials Network;Oncology;Participant;participant enrollment;Patient Participation;Patient-Focused Outcomes;Patients;Pediatrics;Population;Population Heterogeneity;Prevention;Prevention trial;programs;Public Health;Quality of life;Race;racial minority;Recording of previous events;Reduce health disparities;Research;Research Personnel;research study;Risk Factors;Risk Reduction;Rural;Rural Population;screening;Services;Site;Underrepresented Minority;underserved community;Underserved Population;Universities;Urban Population;young adult

PROJECT_TITLE: Georgia CaRes


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Microbiome

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative While it is clear that bacterial pathogens often infect only a subset of available host species, we rarely know the genetic mechanisms that prevent them from making a host jump to colonize new hosts. To address this gap in our knowledge, the goals of this proposal are to determine host genetic factors and interactions with the host-associated microbial community that limit bacterial adaptation to new hosts. The results of this research will inform our understanding of the barriers that prevent a bacterium from colonizing a new host and will improve our ability to predict microbial host jumps.

PI_NAMEs: KARASOV, TALIA  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Bacteria;bacterial genetics;comparative genomics;cross-species transmission;Data;Environment;Evolution;functional genomics;Genetic;Genetic Variation;Genome;genome-wide analysis;Goals;Horizontal Gene Transfer;host-associated microbial communities;improved;Knowledge;Lead;Methods;Microbe;microbial host;Organism;pathogen;pathogenic bacteria;Population;prevent;programs;Pseudomonas;Research;Specificity;System;Variant;Work

PROJECT_TITLE: Identifying limitations on microbial host jumps

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Kidney Disease;Precision Medicine

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRARTIVE Understanding the roles of the individual renal cell types in renal health and disease is critical to develop novel targeted therapies. The PREcision Medicine through IntErrogation of Rna in the kidnEy (PREMIERE) Network will bring investigators from three leading biomedical research institution together to define the gene expression profiles of renal cell types and cell states in their tissue and disease context.

PI_NAMEs: HACOHEN, NIR ;HODGIN, JEFFREY BENTON (contact);KRETZLER, MATTHIAS ;TROYANSKAYA, OLGA G

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: 3-Dimensional;Acute Renal Failure with Renal Papillary Necrosis;Address;analysis pipeline;Anatomy;Architecture;Automobile Driving;Bioinformatics;Biological Markers;Biomedical Research;Biopsy;blood pressure control;Cell Communication;Cell Physiology;cell type;Cells;Cellular biology;Chronic Kidney Failure;clinical care;Cohort Studies;Communities;Complex;Consensus;Core Biopsy;cost;CRISPR/Cas technology;Data;data mining;Data Set;Development;Diabetic Nephropathy;differential expression;Dimensions;Disease;Disease Marker;Disease Pathway;Environment;Event;Excretory function;experience;Fluid Balance;Fluorescent in Situ Hybridization;Funding;Future;Gene Expression Profile;Genes;Genetic Transcription;Health;Heterogeneity;Hormonal;Immune;Immunology;improved;Individual;Injury to Kidney;insight;Institution;interstitial;Kidney;kidney biopsy;kidney cell;Kidney Diseases;Kidney Transplantation;Knowledge;Lead;Length;Link;Lupus Nephritis;Maintenance;Maps;Messenger RNA;Methods;Mitochondria;Molecular;Molecular Analysis;Molecular Biology;Molecular Disease;multidisciplinary;nanopore;Nephrology;Nephrons;new therapeutic target;novel;Participant;Pathology;Pathway interactions;patient subsets;Patients;precision medicine;preservation;Prevention strategy;Process;Protein Isoforms;Protocols documentation;Public Health;quality assurance;Quality Control;Reproducibility;Research;Research Personnel;Resolution;RNA;RNA Splicing;Role;scale up;Science;single-cell RNA sequencing;Site;Sodium Chloride;Stains;Structure;Subgroup;Systems Biology;Techniques;Technology;Therapeutic;therapeutic biomarker;Tissue atlas;tissue injury;Tissue Procurements;Tissues;tool;Transcript;transcriptomics;wasting;Work


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Heart Disease;Hypertension;Prevention;Primary Health Care

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Pharmacologic and behavioral interventions are effective in improving outcomes for cardiometabolic diseases (e.g., hypertension, dyslipidemia, and diabetes), but there is an implementation gap in low- and middle-income countries that leads to substantial excess morbidity and mortality. In this proposal, I will use a stepwise approach in Guatemala to investigate the implementation of the World Health Organization Hearts model of integrated treatment of cardiometabolic diseases, through (1) identifying barriers and facilitators to expanding an ongoing hypertension intervention in Guatemala to also include diabetes and dyslipidemia treatment, as recommended in WHO Hearts; (2) co-designing a delivery model of integrated treatment of cardiometabolic diseases using human-centered design, and (3) evaluating the feasibility and acceptability of the delivery model using a mixed-methods evaluation of a cluster randomized pilot study. This project has high public health relevance as it will develop Dr. Flood’s generalizable implementation research expertise to address gaps in the implementation of evidence-based cardiometabolic disease care in resource-limited health systems in the U.S. and abroad.

PI_NAMEs: FLOOD, DAVID CLIFFORD (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, MAKEDA J

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Anti-Hypertensive Agents;Award;Behavior Therapy;Belize;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;care delivery;career;career development;Caring;Central America;Central American;Cessation of life;Chronic;Chronic Disease;Clinical;Clinical Trials;Consensus;cost effective;Costa Rica;Counseling;Country;design;Developing Countries;Diabetes Mellitus;Disease;Disease Management;Disease Outcome;Dyslipidemias;Educational workshop;effective intervention;effectiveness evaluation;effectiveness outcome;El Salvador;Elements;Evaluation;evidence base;Evidence based intervention;Evidence based treatment;experience;Fellowship;Floods;Funding;Glucose;Goals;Guatemala;Guatemalan;Health;Health Personnel;Health Services;Health system;health training;healthy lifestyle;Heart;Heart failure;Honduras;human centered design;hybrid type 2 trial;Hypertension;hypertension treatment;implementation barriers;implementation intervention;implementation outcomes;implementation research;implementation study;improved;improved outcome;Income;Internist;Intervention;Intervention Studies;Interview;Investments;Knowledge;Latin America;low and middle-income countries;Medicine;member;Mentors;Mentorship;Metabolic Diseases;Methodology;Methods;Michigan;Modeling;Monitor;Morbidity - disease rate;mortality;multi-component intervention;multidisciplinary;Myocardial Ischemia;National Heart, Lung, and Blood Institute;Nicaragua;Nonpharmacologic Therapy;nutrition;Outcome;Panama;Participant;Patients;pharmacologic;Physicians;Pilot Projects;Positioning Attribute;Prevention;Primary Care;Primary Health Care;primary outcome;Protocols documentation;Public Health;public health relevance;Randomized;Recommendation;Research;research clinical testing;Research Methodology;Research Personnel;research study;Resources;Risk;Saints;Sampling;Scientist;skills;Strategic vision;Stroke;Structure;System;therapy design;Training;training opportunity;Translating;Universities;World Health Organization;Zea

PROJECT_TITLE: Implementation research for comprehensive cardiometabolic care in Guatemala

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Data Science;Genetics;Human Genome;Kidney Disease;Precision Medicine

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: We will comprehensively identify cell types and states and their corresponding gene expression, regulation and molecular interactions in human adult kidney tissue from healthy, acute and chronic kidney disease participants. The knowledge created will provide critical insights into developing disease biomarkers for prognosis and diagnosis and designing therapeutic targets.

PI_NAMEs: JAIN, SANJAY  (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Acute Renal Failure with Renal Papillary Necrosis;Adult;ATAC-seq;Atlases;Automobile Driving;Benchmarking;Binding;biobank;Bioinformatics;Biological;Biological Assay;Biopsy;Catalogs;Cell Communication;Cell Nucleus;cell type;Cells;Cellular biology;Chromatin;Chronic;Chronic Kidney Failure;Clinical;clinical care;Collaborations;Complex;Controlled Vocabulary;Cytometry;Data;data integration;Data Set;data sharing;design;Development;Diagnosis;Diagnostic;Disease;Disease Outcome;Endothelium;Ensure;Environment;Epigenetic Process;epigenome;epigenomics;Ethnic Origin;Evaluation;Extracellular Matrix;flexibility;Fostering;Freezing;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genomics;Histologic;Human;Human BioMolecular Atlas Program;Immune;Infrastructure;Injury;Injury to Kidney;insight;Institution;interstitial;Joints;Kidney;kidney biopsy;kidney cell;Kidney Diseases;Knowledge;knowledge integration;large scale data;Measures;Methods;Modality;Molecular;Molecular Biology;molecular phenotype;Molecular Profiling;multimodal data;multimodality;multiple omics;Neighborhoods;nephrogenesis;Nephrology;Nephrons;Nerve;new technology;novel;Organ;Participant;Pathologic;Pathology;Patient Care;patient oriented research;Patients;Phase;precision medicine;Process;Production;prognosis biomarker;programs;Proteins;Protocols documentation;Publications;Quality Control;Race;racial diversity;Recommendation;Regulation;Reporting;Research Personnel;Resolution;RNA;Sampling;Science;sex;Sex Differences;single cell technology;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;Small Nuclear RNA;SNAP receptor;spatial relationship;Specimen Handling;Stromal Cells;synergism;Technology;Text;therapeutic target;Tissue atlas;Tissue Embedding;tissue processing;Tissues;tongue papilla;transcription factor;transcriptome;transcriptomics;Translational Research;Transposase;Tubular formation;Urine;Validation;XCL1 gene

PROJECT_TITLE: Single cell multiomic and spatial atlas of acute and chronic kidney injury


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

PHR: NARRATIVE Tuberculosis is the leading cause of death worldwide. New and repurposed vaccines against TB offer immense promise to reduce TB-related morbidity and mortality, especially in low- and middle-income countries. This project will estimate the potential impact of introducing TB vaccines in four key countries and identify specific vaccination strategies that will maximize population benefit.

PI_NAMEs: NELSON, KRISTIN NICOLE BRATTON (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Acceleration;Accounting;Address;Adolescent;Adult;BCG Vaccine;Behavior;Biological;Birth;career;Cause of Death;Cessation of life;co-infection;Communicable Diseases;community transmission;Country;Data;design;Development;Disease;disease model;Disease Surveillance;disease transmission;disorder prevention;Epidemic;epidemiologic data;Epidemiology;evidence base;Foundations;Future;Goals;Guatemala;Health;Herd Immunity;high risk;high risk population;HIV/TB;Home;Household;Human;Human Resources;Immunization Programs;implementation barriers;Incidence;India;Infection;Infection prevention;International;Interview;Location;low and middle-income countries;mathematical model;Mentors;Modeling;Morbidity - disease rate;mortality;Mozambique;novel vaccines;Pakistan;Participant;particle;Pattern;Persons;Phase;Phase II Clinical Trials;Policies;Policy Maker;Population;Prevalence;prevent;programs;Recommendation;Reporting;Research;Research Personnel;Resources;Risk;role model;Schools;skills;social contact;Social Mobility;Source;Structure;Subunit Vaccines;surveillance data;Surveys;Testing;Time;tool;Training;transmission process;Tuberculosis;Tuberculosis Vaccines;United States National Institutes of Health;Universities;unvaccinated;Vaccination;vaccination schedule;vaccination strategy;vaccine distribution;Vaccine Research;vaccine trial;Vaccinee;Vaccines;Variant;Work;Workplace;World Health Organization

PROJECT_TITLE: Estimating the Epidemiologic Impact of TB Vaccines using Mathematical Models

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative Poor oral health is epidemic among American youth from low income families. School-based educational programs can be a venue for addressing this problem, however they have not been rigorously evaluated and documented as effective. This grant will allow us to plan for, and test the efficacy of an elementary school-based oral health intervention using a cluster-randomized controlled trial design across children from ethnically-diverse, low-income families in Houston, Texas.

PI_NAMEs: SHARMA, SHREELA V (contact)

PROGRAM_OFFICER_NAME: MATTIA, JILL

PROJECT_TERMS: 8 year old;Address;American;Behavior;Behavior Therapy;Behavioral;Caregivers;Caries prevention;Charities;Child;Child Health;Childhood;Clinical;clinical care;Clinical Trials;Code;cohort;Complex;Data;Databases;deciduous tooth;Dental;Dental caries;Diet;Dietary intake;Disease;dosage;Eating;Education;Educational Curriculum;Effectiveness;Effectiveness of Interventions;efficacy evaluation;efficacy testing;elementary school;Enrollment;Environment;Environmental Risk Factor;Epidemic;ethnic diversity;evidence base;experience;feasibility testing;first grade;follow-up;Food;Foundations;Frequencies;fruits and vegetables;global health;Goals;Grant;Health;Health behavior;Health Promotion;health related quality of life;High Prevalence;high school program;Home;Hour;improved;Incidence;Intake;Intervention;intervention effect;kindergarten;Licensing;Low income;lower income families;Measurement;Measures;Mediating;Modeling;Monitor;National Institute of Dental and Craniofacial Research;Nursery Schools;nutrition;Obesity;Oral health;Outcome;Parents;permanent tooth;Physical activity;Pilot Projects;pilot test;Prevalence;prevent;Prevention program;Prevention strategy;process evaluation;programs;Protocols documentation;psychosocial;Psychosocial Factor;Randomized, Controlled Trials;recruit;Research;Research Personnel;Risk;Risk Reduction;school health;Schools;second grade;Smiling;social interventions;study population;Surveys;teacher;Testing;Texas;Tooth structure;tooth surface;Toothbrushing;Training;trial design;trial planning;U-Series Cooperative Agreements;United States;Youth

PROJECT_TITLE: CATCH Healthy Smiles: A cluster-RCT of an elementary school oral health intervention


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Project Narrative Rhythmic behaviors and physiological processes are temporally organized by the central circadian pacemaker to occur at the optimal time of day. Disruption of this precise organization due to disease or lifestyle (shift work, artificial light at night) is associated with negative health outcomes including metabolic, cardiovascular, and mood disorders. Our research program aims to determine the interaction between the genes, neurons, and circuits that time rhythmic behaviors, which will provide a foundation for the investigation of the mechanisms of circadian dysfunction that both lead to, and are a symptom of, disease.

PI_NAMEs: JONES, JEFFREY R (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;African;Animals;Behavior;Behavioral;Biological;Brain;Cardiovascular Diseases;Chronobiology;circadian;circadian biology;Circadian Dysregulation;circadian pacemaker;Circadian Rhythm Sleep Disorders;Communication;Curiosities;Disease;Etiology;ex vivo imaging;Exhibits;Food;Foundations;Gene Expression;Genes;genome editing;Goals;Health;Human;in vivo;Investigation;Laboratory mice;Life Style;Light;Link;Machine Learning;Metabolic Diseases;Molecular;molecular clock;Mood Disorders;multilevel analysis;Mus;Neurons;Neurophysiology - biologic function;novel;Outcome;Output;Partner in relationship;Periodicity;Physiological Processes;Predatory Behavior;preference;programs;Research;Rest;shift work;Signal Transduction;suprachiasmatic nucleus;Symptoms;Time

PROJECT_TITLE: Circadian output mechanisms in nocturnal and diurnal animals

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


NIH_SPENDING_CATS: Asthma;Lung

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative This project will determine mechanisms by which cysteinyl leukotrienes facilitate airway inflammation and airway dysfunction that underlies asthma. The results of the studies should yield information that can be used to generate new therapies, and will also improve our understanding of the causes of asthma.

PI_NAMEs: BOYCE, JOSHUA A (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Agonist;airway epithelium;airway inflammation;antagonist;Arachidonate 5-Lipoxygenase;aspirin-exacerbated respiratory disease;Asthma;asthmatic;Automobile Driving;Basophils;Blood Platelets;Bronchial Hyperreactivity;Brush Cell;Cells;chronic rhinosinusitis;Clinical;Complex;cyclooxygenase 1;Cyclooxygenase Inhibitors;cysteinyl leukotriene receptor;cysteinyl-leukotriene;cytokine;Development;eosinophil;Epithelial Cells;Epithelium;Functional disorder;Generations;Grant;Hematopoietic;immunopathology;improved;Individual;individual variation;Inflammation;Inflammation Mediators;Inhalation;inhibitor;Leukotriene Antagonists;Leukotriene C4;Leukotriene D4;Leukotriene E4;Leukotriene Production;Leukotriene Receptor;Lipids;Lipoxygenase Inhibitors;Lung;Lymphoid Cell;Mediating;Modeling;Mucous Membrane;Nasal Polyps;novel;novel therapeutics;Nucleotides;P2Y2 receptor;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Production;Prostaglandin D2;Pulmonary Inflammation;Reaction;receptor;receptor function;recruit;Regulation;respiratory;Respiratory Disease;respiratory smooth muscle;Role;Series;Severity of illness;Signal Transduction;Smooth Muscle;System;Testing;Therapeutic;Tissues;Transgenic Mice;urinary;Urine

PROJECT_TITLE: Control of Pulmonary Inflammation by Leukotriene E4

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Despite increased attention to diversity and inclusion in recent years, a lack of diversity persists among the biomedical workforce in the U.S. The Duke Preparing Research scholars In bioMEdical sciences-Post- baccalaureate Research Education Program (PRIME-PREP) will develop a diverse pool of talented doctoral researchers and enhance their success in academic careers by providing research experience, mentorship, and skills-building, including promoting development of scholars’ identity as scientists. This program will serve as a model for generating a diverse research workforce and meeting the nation’s needs to advance biomedical innovation.

PI_NAMEs: BASTIDAS, ROBERT J;BLOBE, GERARD C (contact);FRIERSON, JOHNNA M

PROJECT_TERMS: Address;Area;Attention;Awareness;Biology;Biomedical Engineering;Biomedical Research;biomedical scientist;bridge program;career;career development;cohort;Communities;community engaged research;community engagement;curriculum development;Degree program;Development;diversity and inclusion;Doctor of Philosophy;Doctor's Degree;education research;Educational Curriculum;Educational workshop;Ensure;Environment;Equity;Event;evidence base;experience;Face;feasibility research;Fostering;Funding;Goals;Individual;Infrastructure;innovation;Journals;Laboratories;Leadership;medical schools;meetings;Mentors;Mentorship;Minority-Serving Institution;Modeling;next generation;Participant;peer;peer coaching;peer networks;Population;Postbaccalaureate;Productivity;Program Development;programs;prospective;Records;recruit;Research;Research Personnel;Research Project Grants;Research Training;resilience;Scholars Program;Science;Scientist;skill acquisition;skills;Structure;Students;success;Talents;Time;Training;training opportunity;undergraduate student;Underrepresented Students;Universities

PROJECT_TITLE: Duke Preparing Research Scholars in Biomedical Sciences- Post-Baccalaureate Research Education Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Bioengineering;Genetics;Networking and Information Technology R&D (NITRD)

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative A more thorough quantitative evaluation of the transcriptional differences between cells in healthy and diseased states particularly is paramount to our understanding of disease etiology. This includes analyzing the transcriptional differences between diseased cells and appropriate normal counterparts both in terms of gene expression and alternative splicing, as well as potential mRNA subcellular localization differences and cellular spatial-contextual differences within tissues. This proposed work will develop computational tools to enable such analysis using large-scale single-cell RNA-sequencing and spatially resolved transcriptome imaging data.

PI_NAMEs: FAN, JEAN  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Alternative Splicing;Biological;Biological Models;Cell Communication;Cell Cycle;Cell Physiology;Cells;Cluster Analysis;Computer Analysis;Computer software;computerized tools;Computing Methodologies;Data;Development;differential expression;Disease;Etiology;experience;Gene Expression;Genetic Transcription;Goals;Heterogeneity;Homeostasis;Image;Imaging technology;Individual;insight;Measures;Messenger RNA;Molecular;Neuroglia;next generation sequencing;Normal Cell;open source;Pathogenesis;Pattern;Play;Population;Process;programs;Protein Isoforms;Proteins;Quantitative Evaluations;Research;Research Personnel;Role;Signal Transduction;single-cell RNA sequencing;Spliced Genes;Tissues;transcriptome;Translations;Variant;Work

PROJECT_TITLE: Computational methods for delineating subcellular and cellular spatial transcriptional heterogeneity along developmental trajectories

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Methamphetamine;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: Public Health Relevance  This proposal will use cerebral organoids derived from human induced pluripotent stem cells (iPSC) to model HIV interactions with drugs of abuse and combination antiretroviral therapy (cART). We will utilize convergent state-of-the-art electrophysiology, single-cell transcriptomics and a systems biology strategy to generate new mechanistic hypotheses on neuroHIV pathogenesis, HIV interaction with drugs of abuse and cART. Ultimately, this proposal will lead to novel therapeutic concepts to improve neuropsychological functioning in people with HIV and substance abuse comorbidity.

PI_NAMEs: REPUNTE-CANONIGO, VEZ ;SANNA, PIETRO P (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: advanced system;Alcohol abuse;Alzheimer's Disease;Anti-Retroviral Agents;antiretroviral therapy;Astrocytes;Automobile Driving;candidate identification;Cells;Central Nervous System;Cerebrum;chemokine;clinically relevant;Closure by clamp;comorbidity;Computing Methodologies;CRISPR/Cas technology;cytokine;Data;Disease;Disease Progression;Dissection;dopaminergic neuron;Drug abuse;Drug Modelings;drug of abuse;druggable target;Electrophysiology (science);experience;experimental study;Exposure to;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene regulatory network;genetic manipulation;Genomic approach;HIV;HIV Envelope Protein gp120;HIV/AIDS;Human;human induced pluripotent stem cells;improved;in vivo;induced pluripotent stem cell;Inflammation;Injury;innovation;Integration Host Factors;Literature;Macrophage;Mediator;member;Methamphetamine;Microglia;Modeling;Monitor;Morphine;multidrug abuse;Nerve Degeneration;neural circuit;neuroadaptation;neuroAIDS;Neurodegenerative Disorders;neuron loss;Neuronal Differentiation;Neurons;Neuropathogenesis;neuroprotection;Neuropsychology;novel;novel therapeutics;Opioid;Organoids;Pathogenesis;Persons;Pharmaceutical Preparations;Preparation;promoter;Property;Proviruses;public health relevance;reactivation from latency;Regulation;Regulator Genes;response;Role;stem cell organoids;Stimulant;Substance abuse problem;Systems Biology;Testing;Therapeutic;therapeutic target;therapeutically effective;Tissues;transcriptomics;Viral;Viral Proteins;Viral reservoir;Virus

PROJECT_TITLE: Modeling drugs of abuse-HIV interactions using iPSC-derived human cerebral organoids


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PHR: The incidence of acute type B aortic dissection is proportional to the prevalence of uncontrolled hypertension. The results of the IMPROVE-AD trial (including 1100 participants in the US) will provide important clinical guidance on the most appropriate patient-centered ways to reduce mortality and major morbidity by testing two distinct therapeutic strategies. It will also inform decisions regarding racial and gender disparities in patients with uncomplicated type B aortic dissection.

PI_NAMEs: O'BRIEN, SEAN M (contact);VEMULAPALLI, SREEKANTH

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Abdominal Aortic Aneurysm;Acute;Address;Admission activity;Advocate;Ancillary Study;Aorta;Aortic Diseases;Aortic Rupture;arm;Blood Pressure;Blood Pressure Monitors;Blood Vessels;Cessation of life;Chest;Clinical;Clinical Data;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;clinically relevant;Collaborations;Collection;college;Companions;Computers;Cost Analysis;cost effectiveness;Creativeness;Data;Data Collection;Data Coordinating Center;data integrity;data management;Data Reporting;data sharing;Descending aorta;design;Deterioration;Dialysis procedure;Disease;Dissection;electronic data;Electronics;Enrollment;Equipoise;European;Event;experience;Fistula;follow-up;Funding;gender disparity;Guidelines;health difference;Hospitalization;Hypertension;Image;improved;improved outcome;Incidence;indexing;Individual;Industry;Injury;Intervention;Leadership;Medical;Medicine;Monitor;Morbidity - disease rate;mortality;Multicenter Trials;multidisciplinary;National Heart, Lung, and Blood Institute;Operative Surgical Procedures;Outcome;Pain management;Paraparesis;Paraplegia;Participant;patient oriented;Patients;Phase;Policies;Population;pragmatic trial;Preparation;Prevalence;Prevention;primary endpoint;Procedures;Process;protocol development;Publications;Qualifying;Quality Control;Quality of life;Quality of Life Assessment;Questionnaires;racial disparity;Randomized;Recommendation;Renal Replacement Therapy;repaired;Reporting;Research Design;Research Institute;Research Personnel;Safety;Site;Spinal cord injury;standard of care;Statistical Data Interpretation;Strategic vision;Stroke;Surveys;Syndrome;System;Telephone;Testing;Therapeutic;tool;Training;treatment strategy;Universities;Vascular Diseases;Washington;Work

PROJECT_TITLE: 2/2 IMPRroving Outcomes in Vascular DisEase - Aortic Dissection (IMPROVE-AD)


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Lung diseases such as asthma, chronic bronchitis, cystic fibrosis, tuberculosis, emphysema, acute respiratory distress syndrome, and lung cancer cause substantial morbidity and mortality. This program will produce clinical and basic science investigators with broad experience in Pulmonary investigation. The training program will prepare these researchers for the challenges of academic medicine and biomedical research and will help fill the need for the next generation of scientists.

PI_NAMEs: LEWINSOHN, DAVID M. (contact);SLATORE, CHRISTOPHER G.

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TITLE: Multidisciplinary Research Training in Pulmonary Medicine

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


PHR: PROJECT NARRATIVE Metabolic dysregulation is a common and challenging comorbidity in patients with asthma that increases morbidity, mortality and healthcare costs. We will study the effects of targeting the glucagon-like peptide-1 receptor (GLP-1R) pathway on clinical measures of airway inflammation in adults with asthma, using GLP-1R agonist drugs which are already FDA approved for treatment of type 2 diabetes and obesity. Characterizing the effect of GLP-1R agonists on asthma clinical outcomes and mediators of airway inflammation could inform treatment benefits and patient selection, leading to personalized, glucocorticoid-sparing interventions that reduce risk and improve chronic disease management in asthma.

PI_NAMEs: FOER, DINAH  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Address;Adult;Advisory Committees;Aftercare;Agonist;Airway Disease;airway hyperresponsiveness;airway inflammation;Allergens;Asthma;asthma exacerbation;Attenuated;Automobile Driving;biobank;Bioinformatics;Biological Markers;Biometry;Blood Platelets;Body mass index;Cardiovascular system;Caring;Chronic Disease;Clinical;Clinical Research;cohort;comorbidity;Complement;Data;Deterioration;Development;diabetes management;Diabetes Mellitus;diabetes mellitus therapy;Disease Management;Drug usage;Electronic Health Record;Endocrinology;Endothelial Cells;Environment;Epithelial Cells;Event;Exhalation;FDA approved;Funding;Future;GLP-I receptor;glucagon-like peptide 1;Glucocorticoids;glycemic control;Goals;Health;Health Care Costs;health care service utilization;Health system;High Prevalence;Homeostasis;Hyperglycemia;improved;in vivo;incretin hormone;Inflammation;Inflammation Mediators;Inflammatory;Institution;Insulin Resistance;Internal Medicine;Intervention;Link;Measures;Mediating;Mediator;medical schools;Mentors;Mentorship;Metabolic;Metabolic Control;Metabolic Diseases;Metabolic Pathway;Metabolic syndrome;Metabolism;methacholine;Methodology;Methods;Mission;Morbidity - disease rate;mortality;mouse model;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;Nitric Oxide;Non-Insulin-Dependent Diabetes Mellitus;obese patients;Obesity;obesity management;obesity-associated asthma;Outcome;Outpatients;Pathogenesis;Pathway interactions;Patient Selection;Patients;Pharmaceutical Preparations;Placebos;Plasma;Platelet Activation;Platelet aggregation;pleiotropism;Population;Positioning Attribute;pre-clinical;Prevalence;primary outcome;prospective;Public Health;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary Inflammation;Pulmonology;randomized placebo-controlled clinical trial;randomized, clinical trials;recruit;Reporting;research and development;Research Design;Research Personnel;Research Support;Resources;response;Risk;Risk Reduction;Role;routine care;Sampling;Serum;Severities;Source;study population;Symptoms;targeted agent;targeted treatment;Testing;Therapeutic;Thinness;Time;Training;Viral;Weight Gain

PROJECT_TITLE: Effects of GLP-1 Receptor Agonists on Airway Inflammation and Platelet Activation in Asthma


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Genetics;Human Genome;Prevention;Substance Misuse

PHR: PROJECT NARRATIVE Cannabis use disorders are highly prevalent in the U.S., and frequently co-occur with alcohol and other substance use disorders. The proposed research seeks to identify and determine how key genomic variants and pathways interact with each other in a disease-relevant tissue specific context to affect an individual’s risk for drug abuse. The obtained knowledge will be incorporated into a larger disease model and lead to more precision in the understanding of the mechanism underlying risk for cannabis use disorders and thus provide a substrate for more effective prevention and intervention.

PI_NAMEs: PENG, QIAN  (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: addiction;Addictive Behavior;Address;Affect;alcohol comorbidity;alcohol use disorder;Alcohols;clinically actionable;cohort;Cohort Studies;Communities;comorbidity;Complement;Computing Methodologies;Data;Disease;disease model;disorder prevention;Drug abuse;Drug usage;Epigenetic Process;epigenomics;Etiology;Genes;Genetic;genetic architecture;genetic risk factor;genetic variant;genome wide association study;Genomics;Hereditary Disease;Heritability;high dimensionality;high risk population;Human Genome;Individual;insight;Intervention;Knowledge;Link;machine learning algorithm;marijuana use;marijuana use disorder;Mental Health;Methods;Outcome;Pathway interactions;Play;Population;precision medicine;Prevention;programs;Public Health;Regulation;Research;Risk;Role;screening;Signal Transduction;software development;substance use;Substance Use Disorder;System;Tissues;transcriptomics;whole genome

PROJECT_TITLE: Identifying specific genetic pathway interactions for drug use and abuse through integrative omics


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Pediatric

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative In this ambitious team science grant, we propose to develop the first single cell very early onset inflammatory bowel diseases (VEOIBD) cellular atlas and associated VEOIBD networks. We hypothesize that developing this atlas will inform upon disease pathogenesis and enable targeted therapeutics for VEOIBD patients. Moreover, identification and characterization of novel VEOIBD causative genetic variants will inform upon novel IBD pathogenic networks extending beyond VEOIBD. Robust data and resource (organoid) sharing will facilitate translational research and the identification of therapeutic targets for common forms of IBD.

PI_NAMEs: KLEIN, CHRISTOPH ;MUISE, ALEIXO M;SNAPPER, SCOTT B (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: 6 year old;Acceleration;Adolescence;Adult;Affect;Age;Atlases;Bioinformatics;Biological Response Modifiers;Biopsy;Blood;Blood specimen;Boston;Caregivers;causal variant;cell type;Cells;Child;Childhood;Classification;Clinical Data;clinically relevant;Collaborations;Collection;Communities;Complex;Coupled;Cytometry;Data;Data Analyses;data library;Data Set;data sharing;Defect;design;Development;Diagnosis;diagnostic biomarker;Disease;disease diagnosis;early onset;Environment;Environmental Health;Epithelial Cells;Epithelium;Family member;Frequencies;functional genomics;Gastroenterology;Generations;Genes;Genetic;genetic disorder diagnosis;genetic variant;Genomics;Global Awareness;Goals;Grant;gut microbiome;Hematopoietic Stem Cell Transplantation;Immune;Immune system;Immune System Diseases;Immunology;in vitro Model;Inflammatory Bowel Diseases;innovation;International;intestinal epithelium;Intestines;Lead;Link;member;Microbiology;Mission;Molecular;Mucous Membrane;Multiomic Data;multiple omics;Mutation;new therapeutic target;next generation sequencing;novel;novel therapeutics;Organoids;Pathogenesis;Pathogenicity;Pathology;patient oriented;Patient Recruitments;Patients;Peer Review;peripheral blood;personalized care;Phenotype;Physicians;Prognostic Marker;Proteomics;Protocols documentation;Publishing;recruit;Research;Research Personnel;Resources;Sampling;Science;Scientist;Signal Transduction;single-cell RNA sequencing;Site;Standardization;stem cell biology;Stromal Cells;Systems Biology;targeted treatment;Technology;Testing;therapeutic target;Tissues;transcriptomics;Translational Research;Variant;web site

PROJECT_TITLE: Identifying Immune and Epithelial Network Signatures in Very Early Onset Inflammatory Bowel Disease


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: Grand Rapids

ORG_NAME: COREWELL HEALTH

PHR: PROJECT NARRATIVE The Cancer Research Consortium of West Michigan (CRCWM) has over 40 years of community-based clinical trial experience and remains dedicated to assuring that every person in West Michigan, regardless of socioeconomic status, race, or geography, has the opportunity to participate in NCTN/NCORP clinical trials for cancer prevention/control, cancer care delivery, and treatment. These trials are the practice-changing research that improve cancer survival, decrease toxicity, and offer better ways to deliver care with decreased costs. Our partnerships with regional health systems allow us to offer over 130 open and accruing cancer research studies, maintain follow-up for 175 additional trials, offer education to targeted populations, and contribute to the knowledge base surrounding the needs of diverse and underserved populations such as children, adolescents and young adults, racial and ethnic minorities, and rural residents.

PI_NAMEs: BUTLER, KATHLEEN YOST (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;anti-cancer research;base;Basic Science;cancer care;cancer clinical trial;Cancer Control;cancer diagnosis;Cancer Patient;cancer prevention;Cancer Prevention Trial;cancer survival;care delivery;Caring;Child;Clinical;clinical care;Clinical Trials;Communities;Community Clinical Oncology Program;cost;Dedications;Education;Elderly;ethnic minority;experience;Family;follow-up;Geography;Goals;Grant;health care disparity;Health system;Image;improved;knowledge base;Leadership;medical schools;Mentors;Michigan;Minority;Molecular;National Cancer Institute;National Clinical Trials Network;Newly Diagnosed;Oncology;participant enrollment;Patients;Persons;Physicians;Population;Population Heterogeneity;Positioning Attribute;precision medicine;Prevention;programs;Race;racial minority;Recording of previous events;Research;Research Personnel;research study;Rural;rural dwellers;Socioeconomic Status;symptom science;Target Populations;Toxic effect;Underinsured;Underserved Population;young adult


NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOCHEMISTRY

PHR: NARRATIVE Cell plasticity, the ability of cells to change their phenotypes without genetic mutations, is crucial for the development and the progress of diseases such as cancer. Post-transcriptional mechanisms are essential for cell plasticity as they offer a route to regulate cell fate, specifically in response to rapid changes in response to environmental cues. This proposal investigates the mechanisms by which translational control and RNA modifications regulate cell plasticity.

PI_NAMEs: KHOSHNEVIS, SOHAIL  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;Area;Biochemical;Biological Assay;Black Box;Candida albicans;cell behavior;cell type;Cells;Complex;Cues;Data;Deposition;Development;Disease;DNA Sequence Alteration;Eukaryotic Initiation Factor-3;Genetic;Genetic Transcription;Goals;Homeostasis;human disease;Hyphae;Immune response;Impairment;insight;Knowledge;Laboratories;Malignant Neoplasms;Messenger RNA;Methylation;Modification;Morphology;mRNA Translation;next generation sequencing;novel;Organism;Peptide Initiation Factors;Phenotype;Play;Post-Transcriptional Regulation;posttranscriptional;Process;programs;Protein Biosynthesis;Proteomics;Reagent;Research;response;RNA;Role;Route;tool;Translational Regulation;Translations;Work;Yeasts

PROJECT_TITLE: Post-transcriptional regulation of cell plasticity


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PUBLIC HEALTH RELEVANCE This proposal is relevant to public health because it describes development of a novel instrument capable of measuring the mechanical properties of the cornea, which may advance the diagnosis and treatment of keratoconus, the safety and visual outcome of corneal refractive surgeries, and the accuracy of glaucoma screening. Therefore, the proposed research is relevant to the NIH’s mission of fostering innovative research strategies to bolster the nation’s ability to treat disease.

PI_NAMEs: YUN, SEOK-HYUN ANDY (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Age;biomechanical test;Biomechanics;Body part;Caring;Clinic;Clinical;Clinical Data;clinically relevant;Collagen Fiber;Cornea;Corneal Stroma;crosslink;Data;Degenerative Disorder;Dependence;Development;Devices;Diagnosis;diagnostic biomarker;Disease;Elasticity;elastography;Elements;Error Sources;Eye;Fibrillar Collagen;first-in-human;Fostering;Frequencies;Glaucoma;Goals;Human;human study;improved;in vivo;innovation;instrument;interest;Intervention;Keratoconus;Laser In Situ Keratomileusis;Longitudinal Studies;Maps;Measurement;Measures;mechanical properties;Mechanics;Mission;Modulus;Monitor;Morphology;Natural regeneration;novel;Ocular Hypertension;Operative Surgical Procedures;Optics;Outcome;Pathologic;Pathological Dilatation;Patients;Physiologic Intraocular Pressure;Play;prevent;Procedures;Process;Property;Public Health;public health relevance;Reading;Research;Resolution;response;Role;Safety;screening;Shapes;Structure;Study models;System;Technology;Testing;Tissues;tonometry;tool;Ultrasonic Transducer;United States National Institutes of Health;viscoelasticity;Vision;Visual;Visual Acuity

PROJECT_TITLE: In vivo optical coherence elastography of the cornea: mapping shear and tensile moduli


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Sleep and circadian disruption are prominent features of Alzheimer’s Disease (AD). Circadian, or daily, rhythms influence nearly every aspect of our physiology. This work will help researchers understand how molecular rhythms in the brain may influence the progression of AD, contribute to the sleep disruption experienced by AD patients, and influence the time at which AD targeted medications will be most effective.

PI_NAMEs: ANAFI, RON C. (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Acceleration;aged;aging population;Algorithms;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease care;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Behavior;behavior prediction;Behavioral;Biopsy Specimen;Brain;brain control;Brain region;Caregivers;Cell Separation;cell type;Cells;Cessation of life;Chronotherapy;circadian;circadian biology;Circadian desynchrony;Circadian Dysregulation;Circadian Rhythms;circadian transcriptome;Clinical;Collection;Data;Databases;Development;Disease;Disease Pathway;Disease Progression;disease-causing mutation;Drug Targeting;Exhibits;experience;experimental study;Explosion;frontal lobe;Functional disorder;Generations;Genes;Genetic Transcription;genetic variant;Human;human data;human disease;human tissue;In Vitro;Individual;Inflammation;Informatics;Knowledge;Machine Learning;Measures;metabolome;Methods;Molecular;molecular clock;Molecular Profiling;multidimensional data;Mus;Nerve Degeneration;neural;Neurofibrillary Tangles;novel;novel therapeutics;Nuclear;Parietal Lobe;Pathology;Pathway interactions;Patients;Pattern;Periodicals;Periodicity;Pharmaceutical Preparations;Phase;Physiology;Population;Proteins;Public Health;Reporting;Research;Research Design;Research Personnel;Resources;risk variant;Role;Sampling;single nucleus RNA-sequencing;Sleep;Sleep Deprivation;Sleep disturbances;Sleep Wake Cycle;Sorting;Specimen;Structure;Symptoms;Synapses;tau Proteins;Testing;Therapeutic;Time;Tissues;tool;Transcript;transcriptome;Translations;Update;Wakefulness;Work

PROJECT_TITLE: Circadian Organization and Disorder in Alzheimer's Disease


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

PHR: NARRATIVE Pharmaceutical drugs have reduced mortality and morbidity across all areas of medicine; however, key challenges such as undesirable side effects, poor efficacy, and the need for frequent administration or complex administration routes limit their ability to have even more pronounced impact on patient welfare. The projects described within this proposal seek to overcome these challenges by developing injectable drug delivery platforms that can precisely control pharmacokinetics, reduce the frequency at which drug needs to be readministered, deliver biologics in their bioactive form, and enable multi-drug therapies that match dynamic patient needs. To achieve these goals, we will develop surface-eroding biomaterials that protect the encapsulated payload in combination with advanced fabrication methods that define microparticle geometry— and thus the release of drugs encapsulated in surface-eroding materials—to rationally design injectable particles that are compatible with a broad array of drug classes and exhibit predictable release kinetics.

PI_NAMEs: MCHUGH, KEVIN JAMES (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: 3D Print;absorption;Acute;Area;Behavior;Biocompatible Materials;Biological;Biological Products;Chemistry;Chronic;Chronic Disease;Clinical;Complex;controlled release;Disease;Dose;Drug Delivery Systems;Drug Kinetics;drug release kinetics;Dryness;Encapsulated;Exclusion;Excretory function;Exhibits;fabrication;FDA approved;Formulation;Frequencies;Geometry;Goals;Half-Life;Health Care Costs;Hydrophobicity;improved;Injectable;interest;Kinetics;manufacture;Medicine;Methods;model design;Morbidity - disease rate;mortality;multi-photon;nanofabrication;next generation;particle;Patient Compliance;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Pharmacy (field);Polymers;prevent;rational design;Regimen;Route;Running;Safety;side effect;Site;Structure;Structure-Activity Relationship;Surface;System;Therapeutic;therapy duration;Water;welfare

PROJECT_TITLE: Next-Generation Parenteral Drug Delivery Systems for Controlling Pharmacokinetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Hematology;Immunotherapy;Infectious Diseases;Sepsis

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Infections caused by multi-drug resistant bacteria represent a growing threat to human health worldwide. “Super bug” infections are caused by microorganisms that have become resistant to nearly all current antibiotic therapies. The proposed research seeks to develop a new class of immunotherapeutic drugs to address this urgent need.

PI_NAMEs: SCHAAL, JUSTIN BLAINE (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter baumannii;Address;ADME Study;Anti-Infective Agents;anti-microbial drug;Antibiotic Therapy;Antibiotics;Antibodies;antibody test;antimicrobial;Applications Grants;Bacteremia;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Bacterial Model;bacterial resistance;Biochemical Pathway;Biological;Biology;Blood;Canis familiaris;carbapenem resistance;carbapenem-resistant Enterobacteriaceae;Carbapenems;Cell Communication;Cells;Cercopithecidae;Cessation of life;Chemistry;colistin resistance;combat;Combined Modality Therapy;Communicable Diseases;Consensus;Cyclization;cytokine;Data;Defensins;design;Development;Disease Outbreaks;Dose;drug candidate;Drug Kinetics;E. coli bacteremia;Emerging infection;Engineering;Escherichia coli;Evaluation;Flow Cytometry;fungus;Goals;Gram-Negative Bacterial Infections;Hand;Health;Host Defense;Human;Immune;Immune response;immunogenicity;Immunotherapeutic agent;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;intraperitoneal;Intraperitoneal Injections;Investments;Klebsiella pneumoniae;Lead;Leukocytes;Libraries;Malignant Neoplasms;Mass Spectrum Analysis;Maximum Tolerated Dose;Mediating;Methods;microbial;microorganism;Modeling;Molecular;Molecular Target;mouse model;Multi-Drug Resistance;Multidrug-resistant Acinetobacter;Multiple Bacterial Drug Resistance;Mus;Neutrophil Infiltration;Neutrophilia;Nosocomial Infections;novel;novel therapeutics;pathogen;pathogenic bacteria;Peptide Hydrolases;Peptides;Peritoneal;Peritoneal lavage;Peritoneal Sepsis;Phagocytes;Phagocytosis;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacologic Substance;Pharmacology Study;Plasma;pre-clinical;preclinical development;Preventive;Production;Property;Protein Isoforms;Proteins;Protocols documentation;Public Health;Publishing;Radiolabeled;Rattus;Reagent;recruit;Research;Resistance;response;response biomarker;Risk;Route;Safety;safety study;Sepsis;Septic Shock;Septicemia;Signal Pathway;Spleen;Therapeutic;theta-defensin;Toxic effect;Toxicokinetics;Toxicology;United States;uptake;Vertebral column;Whole Blood

PROJECT_TITLE: Host Directed Orynotide for MDR Gram Negative Bacterial Infections


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases;Women's Health Research;Wound Healing and Care

ORG_CITY: IRVINE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Advances in genomics and proteomics have uncovered thousands of previously unannotated small proteins, many of which are encoded on genes implicated in cancer. This proposal seeks to characterize the mechanism of one such novel microprotein with roles in cutaneous wound healing and tumor progression. Successful completion of these studies will enhance our knowledge of how regulators of wound healing are hijacked by cancer, and may provide a new target for the development of cancer therapies.

PI_NAMEs: MARTINEZ, THOMAS FARID (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: 3-Dimensional;Advisory Committees;Affect;Amino Acids;Binding;Bioinformatics;Biology;Breast Cancer Cell;Breast Cancer cell line;Cancer Biology;cancer cell;cancer therapy;career;cell motility;Cell Proliferation;Cells;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Code;Complex;Core Facility;CRISPR screen;Data;data integration;Data Set;Deacetylase;Dependence;Development;Developmental Biology;differential expression;Disease;Educational workshop;Environment;Enzymes;Epidermis;Epigenetic Process;epigenetic regulation;experience;experimental study;Fostering;Foundations;Gene Expression;Genes;Genetic Transcription;Genomics;Goals;HDAC1 gene;Histone Deacetylation;Histones;Homeostasis;Human;Human Cell Line;In Vitro;in vivo;innovation;K-Series Research Career Programs;keratinocyte;knock-down;Knockout Mice;Knowledge;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mammals;Mediating;Mentors;Mentorship;MicroRNAs;migration;Modeling;Modification;Molecular;mouse model;new therapeutic target;novel;NuRD complex;Open Reading Frames;Pathway interactions;Peptides;Phenotype;Process;programs;Proliferating;prostate cancer cell;prostate cancer cell line;protein function;Proteins;Proteomics;Regulation;Research;ribosome profiling;RNA;Role;Running;Signal Pathway;Skin;skin wound;Skin wound healing;Techniques;Testing;Thick;Tissues;Training;transcriptome;transcriptome sequencing;Translating;tumor;tumor progression;Tumor Promotion;tumorigenesis;Undifferentiated;Untranslated RNA;wound;wound closure;wound healing

PROJECT_TITLE: The Roles of a Novel Microprotein in Wound Healing and Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: J. CRAIG VENTER INSTITUTE, INC.

PHR: PUBLIC HEALTH RELEVANCE Klebsiella pneumoniae is an opportunistic nosocomial pathogen that is the cause of severe respiratory, urinary tract and wound infections that can enter the bloodstream and progress to fatal septicemia. Due to the spread of antibiotic resistance, very few drugs remain that can treat these infections. The goal of this project is to optimize our 5-phage therapeutic cocktail and to complete the necessary FDA IND-enabling tests and paperwork in preparation for a future phase 1 clinical trial, which will reduce the impact of K. pneumoniae infections on human health.

PI_NAMEs: FOUTS, DERRICK E (contact)

PROJECT_TERMS: Acute;Address;alternative treatment;Antibiotic Resistance;Antibiotic Therapy;Antibodies;B-Lymphocytes;Bacteria;Bacteriophages;Bar Codes;Benchmarking;Blood Circulation;carbapenem resistance;cellular development;cGMP production;Clinical;Clinical Research;Clinical Trials;Cyclic GMP;cytokine release syndrome;Death Rate;design;Development;Dose;drug testing;efficacy testing;Engineering;Enterobacteriaceae;experience;experimental study;Formulation;Funding;Future;Genome;genome sequencing;Genomics;Goals;Health;Human;Immune response;Immunity;immunoregulation;improved;In Vitro;in vivo;ineffective therapies;Infection;Inflammation;innovation;interest;Investigational Drugs;Investigational New Drug Application;Klebsiella pneumoniae;Label;Lead;lead candidate;lead optimization;Lung infections;manufacture;Methods;microbiome;Modeling;Modification;mouse development;mouse model;Mus;pathogen;pathogenic bacteria;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase I Clinical Trials;preclinical study;Preparation;prevent;process optimization;Production;Public Health;public health relevance;receptor binding;Recording of previous events;Research Institute;Research Personnel;Resistance;resistant Klebsiella pneumoniae;respiratory;safety testing;scale up;Sepsis;Septicemia;Specificity;stability testing;Staphylococcus aureus;synthetic biology;synthetic genomics;System;T-Lymphocyte;Technology;Testing;Therapeutic;therapeutic candidate;Toxicity Tests;treatment strategy;Urinary tract;Virus;whole genome;Work;Wound Infection;wound treatment;Yeasts

PROJECT_TITLE: Optimization, Manufacturing and Testing of a Lead Therapeutic Bacteriophage Cocktail for the Treatment of Antibiotic-Resistant Klebsiella pneumoniae Infections


NIH_SPENDING_CATS: Rural Health

ORG_DEPT: PHYSIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH The proposed program (Developing and Readying Underrepresented Minority Researchers) will provide 10 disadvantaged and underrepresented minority Texas A&M University System students each year the opportunity to participate in the Texas A&M College of Medicine's Summer Research Program (SRP). We have operated a very competitive and highly successful SRP for the past 12 years and our 10-week program offers various seminars on biomedical research as well as training in the responsible conduct of research while providing the 50 “DRUMRs” the opportunity to choose from a number of invested mentors. Increasing the number of and training the next generation of disadvantaged and underrepresented minority researchers in NIDDK-related biomedical research areas is critical to ensure future discoveries that will improve the health and well-being of millions of Americans.

PI_NAMEs: MITCHELL, BRETT M (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Affect;Alaska;American;Area;Biomedical Research;Black race;California;career;Cessation of life;college;Community Health;Country;Disadvantaged;Disadvantaged minority;Disease;Disparity;Eligibility Determination;Enrollment;Ensure;Faculty;faculty mentor;Foundations;Future;Goals;graduate school;Health;Hispanic;Hispanic Populations;improved;Institution;interest;Investments;Laboratories;medical schools;Medicine;Mentors;Minority;Minority Groups;minority investigator;minority undergraduate;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Participant;Personal Satisfaction;Population Heterogeneity;programs;Public Health;Research;Research Project Grants;responsible research conduct;Rural;rural area;Rural Health;Rural Population;Schools;Science;Sister;skills;Student Selections;Students;summer research;System;Texas;Time;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;Work

PROJECT_TITLE: Texas A&M College of Medicine Developing and Readying Underrepresented Minority Researchers (DRUMR) Summer Research Program

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;West Nile Virus;Zika Virus

ORG_CITY: NEW HAVEN

ORG_NAME: L2 DIAGNOSTICS, LLC

ORG_STATE: CT

PHR: NARRATIVE Zika and other related flaviviruses are responsible for human and animal infections in which the mosquito Aedes aegypti is the main vector. Some mosquito salivary components facilitate viral spread in the host. We will develop a vaccine candidate based on the A. aegypti salivary protein AgBR1 to control Zika virus infection and other related flaviviruses in the mouse model and in other rodent models such as guinea pigs and hamsters, which better resemble the human disease.

PI_NAMEs: FIKRIG, EROL  (contact);MARIN LOPEZ, ALEJANDRO

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Active Immunization;Adjuvant;Aedes;Aluminum;Aluminum Hydroxide;Animal Model;Animals;Antibodies;Antibody Response;Antibody titer measurement;antibody transfer;Antibody-Dependent Enhancement;Antigens;Arboviruses;Arthropods;Bite;Blood;Bolus Infusion;Cavia;CD8-Positive T-Lymphocytes;Cells;Clinical;Culicidae;cytokine;Dengue Virus;Development;disease model;Dose;efficacy evaluation;feeding;Flavivirus;Flavivirus Infections;Formulation;Funding;General Population;Granulocyte-Macrophage Colony-Stimulating Factor;Hamsters;Health;Human;human disease;IgE;IgG1;IL8 gene;Immune;Immune response;Immune Sera;Immunization;Immunize;Immunocompetent;Immunocompromised Host;immunodeficiency;Immunodeficient Mouse;immunogenicity;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunologics;immunoregulation;Inbred BALB C Mice;Inbred Mouse;Infection;Interferon Type II;Interleukin-1 beta;Interleukin-10;Interleukin-2;Interleukin-4;Interleukin-5;Interleukin-6;Kinetics;Licensing;Modeling;Montanide ISA-51;mosquito-borne;mouse model;Mus;nonhuman primate;novel strategies;novel vaccines;pathogen;Pathogenesis;Patients;Phase;phase 2 study;Physiological;Play;Poly I-C;Procedures;Prophylactic treatment;Protein Secretion;Proteins;prototype;Regimen;response;Rodent;Rodent Model;Role;Route;Saliva;Salivary;Salivary Proteins;Site;Skin;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Titrations;TNF gene;transmission process;Vaccinated;Vaccination;Vaccine Adjuvant;vaccine candidate;vaccine development;vaccine trial;Vaccines;vector;Viral;Viral Antigens;viral transmission;West Nile virus;ZIKA;Zika Virus;Zika virus vaccine;ZIKV infection

PROJECT_TITLE: A novel vaccine against mosquito-borne Zika virus based on mosquito salivary gland protein AgBR1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-P(11)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHARLOTTE

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

PHR: Continued progress in the life sciences depends on researchers having access to powerful visualization software tools that make it easy for them to discover and visually analyze novel patterns and trends in data. My research investigates methods for creating such software, focusing on building tools to visually analyze data from large- scale genomics assays used in research and clinical settings. My program trains students in advanced, state-of-the-art software development methods while creating open source genome visualization software that is freely available for everyone to use.

PI_NAMEs: LORAINE, ANN E (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Algorithms;analytical tool;Big Data;Bioinformatics;Biological Assay;Biological Sciences;Charge;Clinical;Cloud Computing;cloud platform;Cognitive;cognitive system;Collaborations;Collection;Communities;Complex;computer science;Computer software;Computers;cost;Data;data visualization;experimental study;Faculty;Genome;genome browser;Genomics;improved;innovation;Knowledge;large scale data;Learning;Life;method development;Methods;novel;novel strategies;open source;Pattern;Pattern Recognition;Privatization;programs;Public Sector;Research;Research Personnel;Resources;Scientist;skills;Software Design;software development;Software Tools;student training;Students;tool;Training Programs;trend;Visual;Visual System;Visualization;Visualization software

PROJECT_TITLE: Visualization software for genomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Clinical Research;Lung;Organ Transplantation;Precision Medicine;Prevention;Transplantation

ORG_CITY: SEATTLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Exosome-based research in the field of lung transplantation is a rapidly growing area and understanding their role in clinical outcomes, such as primary graft dysfunction (PGD) and acute cellular rejection (ACR), could lead to the identification of potential prognostic biomarkers for risk-stratification. Risk-stratification could be used clinically to better select recipients and match them with donors leading to improved patient outcomes or guide alterations in immunosuppressive management. Additionally, the knowledge gained from these studies would represent the first step towards precision donor/recipient endotyping allowing for the development of novel, targeted therapeutic interventions.

PI_NAMEs: FARJAH, FARHOOD ;MULLIGAN, MICHAEL SCOTT (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute;adaptive immunity;Address;American;Antigens;Area;biobank;Biological Markers;biomarker identification;Blood;cell type;Cells;Chronic;Clinical;Clinical Research;clinical risk;cohort;Collection;Cytometry;Data;Data Collection;Development;Diameter;Disease;Event;Exhibits;exosome;extracellular vesicles;follow-up;Fred Hutchinson Cancer Research Center;Functional disorder;Future;Goals;graft dysfunction;high risk;Immune;Immune response;immunoregulation;Immunosuppression;improved;Infrastructure;innovation;insight;Investigation;Knowledge;Lipid Binding;Lung;lung allograft;Lung Diseases;Lung Transplantation;Measurement;Measures;Mediating;Methodology;Michigan;Modification;mortality;mortality risk;National Heart, Lung, and Blood Institute;Natural Immunity;new therapeutic target;novel;novel therapeutic intervention;Outcome;outcome prediction;Pathogenesis;Patient-Focused Outcomes;Patients;Phenotype;post-transplant;predictive marker;predictive modeling;Probability;Prognostic Marker;Prospective, cohort study;Protocols documentation;Quality of life;Raman Spectrum Analysis;Reporting;Research;Research Design;Research Priority;Risk;Risk Estimate;Risk Factors;risk prediction;risk stratification;Role;Sampling;Specimen;Statistical Data Interpretation;Stratification;targeted treatment;Therapeutic Intervention;Thoracic Surgical Procedures;tool;Transplant Recipients;Transplantation;Transplantation Immunology;Universities;Validation;vesicular release;Washington;Wisconsin

PROJECT_TITLE: Lung transplant recipient exosome phenotypes and the risk of primary graft dysfunction and acute lung allograft dysfunction


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Diabetes;Estrogen;Nutrition;Obesity;Prevention;Women's Health Research

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Aging and obesity are strong risk factors for breast cancer in women because as ovarian estrogen declines, women have less protection from the harmful effects of obesity, which causes inflammation and increases insulin levels. These harmful effects can be reversed by weight loss but this is often not sustainable. We have shown that a novel dietary intervention using time-restricted feeding of a western-style, high-fat diet prevents the effect of obesity to drive breast cancer in mice; the proposed studies will investigate the mechanisms underlying this beneficial effect.

PI_NAMEs: WEBSTER, NICHOLAS J (contact)

PROGRAM_OFFICER_NAME: EMENAKER, NANCY J

PROJECT_TERMS: Acceleration;Age;Age Years;Aging;animal data;antitumor effect;Automobile Driving;Autophagocytosis;Behavior Therapy;blood glucose regulation;Body Weight decreased;Breast Cancer Model;Breast Cancer Prevention;Breast Cancer Risk Factor;Breast Cancer therapy;cancer cell;cancer initiation;Cancer Model;cancer risk;cancer survival;cancer therapy;Carcinogens;Cell Proliferation;Central obesity;chemotherapy;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical Research;Colon Carcinoma;combat;Cues;Data;Diagnosis;dietary;Dietary Intervention;Disease-Free Survival;Distant Metastasis;Dose;Eating;Elements;Energy Intake;epidemiologic data;Epidemiology;epidemiology study;Estrogen decline;Estrogen receptor positive;experimental study;Exposure to;Fasting;feeding;genetic approach;Goals;Growth;Health Benefit;High Fat Diet;Hormonal;hormone therapy;Human;Hyperinsulinism;improved;in vivo;Incidence;Inflammation;inflammatory breast cancer;Insulin;Insulin Receptor;Insulin Resistance;insulin signaling;Intake;Intervention;Lead;Link;Liver;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant Neoplasms;Mammary Neoplasms;Mediating;Metabolic;mortality;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;novel;Nutrient;obese person;Obesity;Obesity Epidemic;Omega-3 Fatty Acids;Oncogenes;orthotopic breast cancer;Outcome;Ovarian;patient derived xenograft model;Patients;Population;Postmenopause;pre-clinical;preclinical study;Premenopause;prevent;Proliferating;Protein Inhibition;Receptor Signaling;Recurrence;reduced food intake;response;Risk;Rodent;Role;Series;Signal Pathway;Signal Transduction;synergism;Testing;Time;time use;Time-restricted feeding;Tissues;translational approach;translational potential;Translations;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor progression;weight loss intervention;Woman

PROJECT_TITLE: Time-restricted feeding and breast cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Natural Products;Pneumonia;Pneumonia and Influenza;Urologic Diseases

ORG_CITY: Salt Lake City

ORG_NAME: CURZA INC

PHR: Project Narrative Cūrza is developing the CZ-02 platform of antibiotics to treat antibacterial-resistant superbugs. CZ-02s exhibit activity via a novel mechanism of action with efficacy demonstrated in multiple animal models of infection. The project proposed will expand the spectrum of activity for CZ-02s to include the Gram-negative non-fermenters A. baumannii and P. aeruginosa thus targeting all of the ESKAPE pathogens that pose a threat to global public health.

PI_NAMEs: SEBAHAR, PAUL  (contact)

PROJECT_TERMS: Abdominal Infection;Acinetobacter baumannii;acute toxicity;Address;analog;Animal Model;Anti-Bacterial Agents;Antibiotics;Autopsy;Bacteremia;Bacteria;Bacterial Antibiotic Resistance;Bacterial Drug Resistance;Bacterial Proteins;Binding;Binding Proteins;Biochemical;Biological;Biological Assay;Blood;Body Weight;candidate selection;carbapenem resistance;Cells;Chemistry;Clinical;Clinical Chemistry;clinically relevant;Complete Blood Count;Cyclic GMP;Cytochrome P450;cytotoxicity;Data;Development;Dose;Dose Fractionation;drug candidate;drug discovery;drug efficacy;Drug Kinetics;Drug resistance;efficacy study;efficacy testing;Engineering;Ensure;Escherichia coli;Escherichia coli drug resistance;ESKAPE pathogens;Eukaryotic Cell;Evaluation;Event;Exhibits;experimental study;falls;Formulation;Frequencies;genotoxicity;Goals;good laboratory practice;Gram-Positive Bacteria;HepG2;In Vitro;in vitro activity;in vitro Assay;in vivo;indexing;Infection;inhibitor;Intra-abdominal;Investigational Drugs;Klebsiella pneumoniae;Lead;lead candidate;lead optimization;lead series;Link;Liver Microsomes;Mammalian Cell;manufacture;manufacturing scale-up;Maximum Tolerated Dose;meetings;Metabolic;meter;Mitochondria;Modeling;Modification;Monitor;Multi-Drug Resistance;multi-drug resistant pathogen;Mus;Mutation;Mycobacterium tuberculosis;Natural Products;new chemical entity;novel;pathogen;pathogenic bacteria;Pathology;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology;Phase;Plasma;Pneumonia;preclinical development;preservation;programs;Property;Protein Biosynthesis;Protein Isoforms;Protein Synthesis Inhibitors;Pseudomonas aeruginosa;Public Health;Rattus;receptor binding;Research Personnel;Resistance;resistance frequency;response;Ribosomes;Route;Safety;Series;Site;Small Business Innovation Research Grant;Staphylococcus aureus;Structure;Superbug;Testing;therapeutically effective;Thigh structure;Time;Toxic effect;Toxicology;Universities;Urinary tract infection;Utah;Visit

PROJECT_TITLE: A New Class of Broad-Spectrum Antibacterial Agents to Treat Multi-Drug Resistant Pathogens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Complementary and Integrative Health;Nanotechnology;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Narrative This project aims to develop a broadly applicable platform for targeting and modulating activity of neurons and other electrogenic cells anywhere within the body. This approach will be further applied to interrogate circuits connecting the enteric (gut) neurons to the midbrain pathways delivering insights into the role of gut-brain connections in modulating dopamine-dependent behaviors. Our technologies and findings would pave way for development of organ-centric therapies for neurological and mental conditions.

PI_NAMEs: ANIKEEVA, POLINA O (contact)

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: adeno-associated viral vector;Behavior;Brain;Capsid;Cells;Chemicals;Dopamine;empowerment;Enteral;free behavior;Functional disorder;gastrointestinal;Homing;Hybrids;insight;interest;Intervention;Ion Channel;Link;Location;magnetic field;Magnetism;mechanical stimulus;Midbrain structure;model organism;Mood Disorders;Moods;Motivation;motor behavior;nanomagnetic;nanomaterials;Nervous System;Neurologic;Neurons;Organ;organ growth;Pathway interactions;Peripheral;Property;Psyche structure;receptor;Rewards;Role;Signal Transduction;social deficits;Specificity;Stress;Technology;Testing;Tissues;tool;Transducers;transmission process;Viral;Viral Vector;Work

PROJECT_TITLE: Fusion of nanomagnetic and viral tools to interrogate brain-body circuits


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunization;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Our desire to replace or complement chemoradiotherapy with immunotherapy for children with solid or brain tumors is undermined by the fact that most of these tumors have very few genetic mutations and very few T cells in the tumor. The blood brain barrier prevents many immunotherapies from entering the brain. We propose protein engineering strategies to create next-generation bispecific T cell engagers that overcome these barriers and instruct patients’ own T cells to kill the cancer cells.

PI_NAMEs: KALIA, VANDANA ;OLSON, JAMES M (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Acceleration;Address;Affinity;Alpaca;Antibodies;antigen binding;Autologous;Automobile Driving;bi-specific T cell engager;Binding;Binding Proteins;Biodistribution;Bispecific Antibodies;Blood - brain barrier anatomy;Brain;Brain Neoplasms;Bypass;cancer cell;carcinogenesis;CD3 Antigens;Cell Death;cellular engineering;chemokine;chemoradiation;Child;Childhood;Childhood Solid Neoplasm;clinical development;Communities;Complement;Core-Binding Factor;cross reactivity;Cystine;cytokine;cytokine release syndrome;Data;Diffuse intrinsic pontine glioma;diffuse midline glioma;DNA Sequence Alteration;drug development;Engineering;Exclusion;exhaustion;extend lifespan;Granzyme;Hematologic Neoplasms;Human;immunogenic;immunological synapse;Immunologics;Immunologist;Immunotherapeutic agent;Immunotherapy;implantation;improved;in vitro activity;in vivo;Industry;Injections;invention;Life;Life Expectancy;Liver;Malignant Childhood Neoplasm;Malignant Neoplasms;manufacture;Maximum Tolerated Dose;Mediating;MLL gene;Modeling;Monoclonal Antibody HuM291;mouse model;Mus;Mutation;neoplastic cell;Neuroblastoma;new technology;next generation;novel;Operative Surgical Procedures;patient derived xenograft model;Patients;Pediatric Hematology;pediatric patients;perforin;Polymers;Population;preclinical development;prevent;Production;programmed cell death ligand 1;Protein Engineering;Proteins;Research Personnel;resistance mechanism;response;Risk;Safety;Solid Neoplasm;Spleen;T cell infiltration;T-Cell Receptor;T-Lymphocyte;Techniques;Testing;Therapeutic;Therapeutic antibodies;therapeutic protein;Time;Toxic effect;trafficking;Treatment Failure;tumor;Tumor Antigens;tumor microenvironment;Unresectable;vaccination strategy;Work;Xenograft procedure

PROJECT_TITLE: Bispecific Antibody Therapeutics for Neuroblastoma and Diffuse Midline Glioma


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: RELEVANCE In this study, we propose to utilize modern computer algorithms to harmonize MRI data across different scanners and different institutions. This is a necessary and currently unmet condition for widespread adoption of quantitative analysis of breast MRIs.

PI_NAMEs: MAZUROWSKI, MACIEJ A. (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Abdomen;Address;Adoption;Algorithms;Appearance;Brain;Breast;breast imaging;Breast Magnetic Resonance Imaging;Cancer Detection;cancer risk;Clinical;clinical application;clinical implementation;clinical practice;Collaborations;Computational algorithm;contrast enhanced;convolutional neural network;Data;Data Set;deep learning;deep learning algorithm;Diagnosis;Disease;Evaluation;expectation;experience;generative adversarial network;genomic signature;Genomics;Head;high risk;Hip region structure;Image;imaging modality;improved;innovation;Institution;Journals;linear transformation;Machine Learning;Magnetic Resonance Imaging;Malignant Neoplasms;Mammary Neoplasms;Manufacturer;Methodology;Methods;Modeling;Modernization;Modification;Noise;novel;novel strategies;Organ;Paper;patient prognosis;Patient-Focused Outcomes;Patients;practical application;predictive modeling;Publications;radiologist;radiomics;reconstruction;Reproducibility;Research;Research Personnel;Scanning;Scientist;Source;Structure;Texture;Thinking;Time;Tissues;Training;Translations;tumor;Validation;Work

PROJECT_TITLE: Harmonization of breast MRI data

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Cancer

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Standard strategies for cancer treatment can have substantial systemic toxicity and while they might provide some short-term efficacy, they are rarely curative in all patients - thus, there is a critical need for new treatments with durable responses and better approaches to prevention. Cancer immunotherapy has made major breakthroughs in the last decade and is likely to have a greater impact in the future. Our Cancer Immunology Training Program (CITP) seeks to train the spectrum of basic to applied and predoctoral to postdoctoral clinical fellows and young scientists to carry out the next generation of cutting-edge research, within the ideally suited, dynamic environment of the University of Pittsburgh School of Medicine and the UPMC Hillman Cancer Center.

PI_NAMEs: BINDER, ROBERT J;VIGNALI, DARIO AA (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Training Programs;tumor immunology

PROJECT_TITLE: Cancer Immunology Training Program

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biotechnology;Cardiovascular;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_NAME: YALE UNIVERSITY

PHR: Existing interventions for peripheral arterial vascular injury or peripheral arterial atherosclerosis, including autologous, synthetic, or primary cell-based tissue engineered vascular grafts (TEVGs), are insufficient to address a significant subset of patients requiring immediate intervention due lack of suitable vessel availability, potential for infection, a long patient wait-time (~23 days), or dysfunctional endothelium leading to thrombus formation. Human induced pluripotent stem cells (hiPSCs) provide a unique, unlimited cell source to produce TEVGs of comparable quantity over a large scale, and can be modified genetically to produce hypoimmunogenic “universal” cells which would be suitable for safe transplant into any patient recipient. This project details our current and future efforts to extensively validate the hypoimmunogenic nature of endothelial cells (ECs) derived from genetically modified hiPSCs, and storage potential of acellular, endothelialized hiPSC-TEVGs so as to be readily available to patients in need, through both in vitro assays and in vivo implantation into a humanized rat model.

PI_NAMEs: QYANG, YIBING  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Accidents;Acute;Address;Adsorption;Aging;Aorta;Arterial Injury;Atherosclerosis;Autologous;Autologous Transplantation;Biocompatible Materials;biomaterial compatibility;Bioreactors;Blood;Blood coagulation;Blood Platelets;Blood Vessel Prosthesis;Blood Vessels;Bypass;CD47 gene;Cell Differentiation process;Cell Line;cell type;Cells;Chronic;Clinic;Clinical;Collaborations;Collagen;combat;CRISPR/Cas technology;Derivation procedure;Development;Diabetes Mellitus;Diameter;Disease;Eating;Economics;efficacious treatment;Endothelial Cells;Endothelium;Engineering;experimental study;Extracellular Matrix;Female;Fibrinogen;follow-up;Future;Gene Modified;Genes;Glean;Glycocalyx;Goals;Hemodialysis;Heparin;Histocompatibility Antigens Class I;Histologic;HLA Antigens;Human;Human body;human induced pluripotent stem cells;Immune system;immunodeficiency;immunogenicity;Immunology;immunoreactivity;Implant;implantation;In Situ;In Vitro;in vitro Assay;in vivo;in vivo Model;induced pluripotent stem cell technology;Infection;infection risk;injured;Injury;Intervention;Investigation;Jordan;Ligation;male;mechanical properties;Mechanics;Modeling;Nature;nonhuman primate;novel;Operative Surgical Procedures;overexpression;patient subsets;Patients;Performance;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Physiologic pulse;pluripotency;Polyglycolic Acid;Population;prevent;Property;Prosthesis;Rattus;Reproducibility;Risk;Rodent Model;scaffold;self-renewal;Signal Transduction;Smooth Muscle Myocytes;Somatic Cell;Source;stem cell biology;stem cells;Stenosis;success;Surface;Technology;Testing;Thrombosis;Thrombus;Tissue Engineering;tissue stem cells;transcription activator-like effector nucleases;Transplantation;Treatment Efficacy;Ultrasonography;Validation;Vascular Diseases;Vascular Graft;vascular injury;Vascular Smooth Muscle;vascular tissue engineering;virtual;Wait Time;Whole Blood

PROJECT_TITLE: Development of HLA engineered universal vascular grafts from human iPSCs

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_CITY: MADISON

ORG_NAME: IMMUTO SCIENTIFIC, INC.

ORG_STATE: WI

PHR: Project Narrative The goal of this SBIR Phase II project is to develop a robust, high throughput, automated benchtop instrument to perform Hydroxyl Radical Protein Footprinting (HRF) for analysis of three-dimensional structures in protein therapeutics. This instrument will enable structural characterization of proteins at a much higher throughput than traditional techniques to better drive the discovery and development of protein therapeutics.

PI_NAMEs: CHOUDHURY, FARAZ  (contact)

PROGRAM_OFFICER_NAME: BILLINGSLEA, EDDIE

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adopted;Amino Acids;Amplifiers;Antibodies;antibody and antigen binding;Antigens;Autoimmune Diseases;Autoimmunity;Binding Sites;Biological Process;Biological Products;Biological Response Modifier Therapy;Biotechnology;Collaborations;commercial application;Communicable Diseases;Complex;Computer software;Consumption;Coupling;COVID-19;Cryoelectron Microscopy;Data;Data Analyses;design;detection platform;Development;Diagnostic;Disease;Dose;Double-Blind Method;drug development;drug discovery;drug efficacy;Drug Industry;Engineering;Ensure;Epitope Mapping;Exposure to;Feedback;Fiber Optics;Genetic Diseases;Goals;Guidelines;Health;Higher Order Chromatin Structure;Hour;Human;Hydroxyl Radical;improved;Industry;Industry Standard;Inflammation;instrument;Insulin;Knowledge;Label;Lasers;Life;Malignant Neoplasms;manufacture;Manufacturer;Marketing;Mass Spectrum Analysis;Measurement;Measures;Medicine;Methionine;methionine sulfoxide;Methods;Modern Medicine;Modification;Molecular Conformation;Monoclonal Antibodies;Outcome;oxidation;Performance;performance tests;Peroxides;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phase 1 study;photomultiplier;Plasma;Preparation;Process;Property;Protein Engineering;Protein Footprinting;Protein Region;protein structure;Proteins;prototype;Quality Control;rapid growth;Recombinant Vaccines;Reproducibility;Research Personnel;Resolution;Resources;response;Safety;Sampling;Signal Transduction;Small Business Innovation Research Grant;Solvents;Source;Speed;Structure;Surface;System;Techniques;Technology;Testing;Therapeutic antibodies;therapeutic protein;three dimensional structure;Three-dimensional analysis;Time;timeline;tool;Tube;United States Food and Drug Administration;Universities;Vaccines;voltage;Water;Wisconsin;X-Ray Crystallography

PROJECT_TITLE: Plasma-Generated Hydroxyl Radicals for Analysis of Three-Dimensional Structures in Protein Therapeutics


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Lung;Organ Transplantation;Prevention;Transplantation

PHR: Lung transplantation is a vital therapeutic option for select individuals with end-stage lung disease, however patient outcomes lag behind other solid organ transplants. The major early complication, primary graft dysfunction (PGD), is acute lung injury occurring in the first 3-days after transplant. This proposal seeks to establish a Lung Transplant Consortia Clinical Center between Pittsburgh, UCSF and Hopkins to investigate the impact of severe PGD on major clinical outcomes and airway inflammation in the first-year after transplant.

PI_NAMEs: GREENLAND, JOHN ;MCDYER, JOHN F (contact);MERLO, CHRISTIAN A

PROJECT_TERMS: Acute;Acute Lung Injury;Address;airway epithelium;Airway Fibrosis;airway inflammation;Allografting;Bacterial Infections;biobank;Bioinformatics;Biological;Biometry;Bronchiolitis Obliterans;Bronchitis;Cells;Chronic;Clinical;clinical center;clinical phenotype;Collaborations;Complication;Data;Development;Diagnosis;Distal;Epidemiology;Epithelial Cells;Epithelium;Event;experience;Faculty;falls;Forced expiratory volume function;Functional disorder;Future;Gene Expression;Genes;genetic signature;graft dysfunction;Greenland;Human Resources;Hypoxemia;Hypoxia;Immune;immune activation;Immune response;Immune Targeting;Immunity;Impairment;Individual;Infection;Inflammation;Inflammatory;injured airway;Injury;insight;Intervention Studies;Knowledge;Link;Lung;lung allograft;Lung Diseases;Lung infections;Lung Transplantation;Lymphocyte;Metagenomics;Molecular;multidisciplinary;novel;novel marker;Organ Transplantation;Outcome;Pathogenesis;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;post-transplant;predictive signature;Predisposition;prevent;Prevention;Process;Productivity;programs;Publishing;Pulmonary Edema;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Recording of previous events;repaired;Reperfusion Injury;Research;respiratory hypoxia;Respiratory Tract Infections;Risk;Risk Factors;Role;Sampling;Science;Site;Solid;Standardization;Stimulus;success;Techniques;Testing;Therapeutic;Time;transcriptome;transcriptome sequencing;Translational Research;transplant centers;Transplant Recipients;transplant registry;Transplantation;Transplantation Immunology;United States National Institutes of Health

PROJECT_TITLE: The Clinical and Molecular Impacts of Lung Primary Graft Dysfunction


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Head and Spine Injury

ORG_CITY: ROCHESTER

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Vertigo/disequilibrium, frequent medical complaints for adults, are related to balance problems and falls which negatively impact health and quality of life. There is no universally effective therapy to address these persistent abnormal self-motion perceptions which result in reduced participation in typical life activities. This project will develop novel approaches to rehabilitation, specifically addressing the need for a deeper understanding of self-motion perception and how self-motion perception can be adapted.

PI_NAMEs: ANSON, ERIC RICHARD (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Achievement;Address;Adult;Affect;Anxiety;Area;Arousal;Attention;Balance training;Basic Science;Behavioral;Brain Concussion;Caring;Chronic;Clinic;Cognition;Cognitive;Cognitive Therapy;cohort;comparison control;Complex;Data;Development;Disease;Dizziness;Doctor of Philosophy;effective therapy;emotion regulation;Emotional;Emotions;Ensure;Equilibrium;Equipment;Etiology;Exercise;experience;Eye Abnormalities;Eye Movements;fall risk;falls;Foundations;Functional disorder;Future;Goals;Health;Hearing;Height;Human;improved;improved outcome;Individual;innovation;insight;K-Series Research Career Programs;Lead;Life;Link;Measures;Medical;Mentors;Methods;Motion;Motion Perception;Movement;multidisciplinary;multisensory;Musculoskeletal Equilibrium;National Institute on Deafness and Other Communication Disorders;novel strategies;Pathology;Patients;Perception;Peripheral;Physiological;Physiology;Play;Posture;Proprioception;Psychophysics;Quality of life;Recovery;Reflex action;rehabilitation strategy;Rehabilitation therapy;Research;Research Methodology;Research Personnel;Resources;Role;Rotation;Science;Scientist;Sensory;sensory integration;Series;Statistical Methods;Strategic Planning;stressor;Symptoms;Testing;therapy development;Training;Translational Research;Translations;Universities;Vertigo;Vestibular Diseases;vestibular reflex;vestibular system;vestibulo-ocular reflex;virtual;Vision

PROJECT_TITLE: The Development of Vestibular-Perceptual Adaptation Paradigms for Treating Persistent Vertigo & Perceived Disequilibrium

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative G protein coupled receptors (GPCRs) module important physiological processes, such as vision, taste, blood pressure regulation, immune response, mood control and so on and are the targets of more than 30% of all therapeutic drugs. I propose to visualize how a key regulatory protein, arrestin, interacts with GPCRs at near-atomic resolution using cryo-electron microscopy. Structural details of various GPCR−arrestin complexes will help dissect the mechanism of GPCR function and guide the design of drugs targeting this specific pathway.

PI_NAMEs: CHEN, QIUYAN  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Arrestins;Binding;blood pressure regulation;Calcium;Cells;chemokine receptor;Complex;Cryoelectron Microscopy;design;Dissection;Drug Design;Drug Targeting;G protein coupled receptor kinase;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;genetic regulatory protein;GTP-Binding Proteins;Hormones;Human;Immune response;insight;Intervention;Ions;Mediating;Molecular;Moods;Neurotransmitters;novel;Pathway interactions;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Photons;Physiological Processes;protein complex;Publishing;receptor binding;receptor function;Reporting;Resolution;response;Safety;Signal Pathway;Signal Transduction;Structure;Taste Perception;Therapeutic;tool;Transducers;Vision;Visualization

PROJECT_TITLE: Structural Basis and Molecular Mechanism of GPCR-Arrestin Interactions

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative This research and training plan will provide advanced training in stem cell biology and functional genomics that will support a career in cutting-edge neurodegenerative disease research. These innovative approaches will be used to develop novel stem cell models from donors of diverse populations and to define the molecular mechanisms underlying genetic risk for tauopathy.

PI_NAMEs: MINAYA, MIGUEL  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Affect;African;African American population;Asian;Asian Americans;Binding;Biology;Brain;Brazil;C-terminal;Calcium;career;Categories;Cell Line;Cell model;clinical application;Collection;Communities;Coupled;CRISPR interference;CRISPR screen;Data;Disease;Dominant Genes;donor stem cell;Engineering;European;European ancestry;Exons;Foundations;Frontotemporal Lobar Degenerations;Functional disorder;functional genomics;Gene Silencing;Genes;Genetic;Genetic Risk;genome editing;Genome engineering;Genomic approach;Genomics;Goals;Homeostasis;Human;Human Genetics;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Inherited;innovation;International;Japan;Maps;MAPT gene;Mentors;Molecular;molecular drug target;Molecular Genetics;Molecular Profiling;Mutation;Neurodegenerative Disorders;neuron development;Neurons;new therapeutic target;Nigeria;novel;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;Population;Population Heterogeneity;Postdoctoral Fellow;Process;programs;proteostasis;Research;Research Personnel;RNA Splicing;screening;South American;stem cell biology;stem cell model;Synapses;tau Proteins;Tauopathies;Techniques;Therapeutic Intervention;therapeutic target;tool;Toxic effect;Training;transcriptome sequencing;transcriptomics;Translating;Work

PROJECT_TITLE: Molecular drivers of tauopathies in stem cell models from diverse human populations

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]