NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention;Sleep Research

PHR: PROJECT NARRATIVE Sleep disturbances are increasingly recognized as a risk factor for Alzheimer’s disease (AD) and a marker for AD pathology. The sleep-wake cycle affects the cerebrospinal fluid (CSF) concentrations of proteins critical to AD pathogenesis, such as Aβ and tau, although other processes (e.g., immune response, synaptic function) are also involved. Dual orexin receptor antagonists (DORAs), such as suvorexant, block the interaction of wake-promoting neuropeptides called orexins and induce sleep. DORAs have been found to decrease the ratio of phosphorylated tau to unphosphorylated tau in humans as well as AD pathology in animal models. In this project, we will test the hypothesis that chronic treatment with suvorexant will decrease CSF and plasma AD biomarkers. Optimal trial design is essential prior to launching a full primary or secondary prevention trial with a maximum chance of success. This study will provide critical information for designing AD secondary prevention trials using suvorexant obtaining data on pharmacokinetics, safety, and chronic effects of suvorexant on multiple soluble AD biomarkers.

PI_NAMEs: LUCEY, BRENDAN PATRICK (contact)

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: abeta deposition;Acute;Adult;Adverse effects;Affect;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Amyloid deposition;amyloid pathology;Animal Model;antagonist;Biological;Biological Markers;Blood;Cerebrospinal Fluid;Cessation of life;Chronic;Cognition;Cognitive;Data;Dementia;Deposition;design;Dose;Drug Kinetics;FDA approved;feasibility testing;Hour;Human;human old age (65+);hyperphosphorylated tau;hypocretin;Immune response;Immunologic Markers;Impaired cognition;Individual;Inflammatory;innovation;Intercellular Fluid;Liquid substance;Measures;Mediating;modifiable risk;Mus;Nerve Degeneration;Neuropeptides;Participant;Pathogenesis;Pharmacodynamics;Phase;Phosphorylation Site;Placebos;Plasma;Polysomnography;Prevention approach;Prevention trial;primary outcome;Primary Prevention;Process;Production;Protein Isoforms;Proteins;Protocols documentation;Puncture procedure;Randomized;receptor;Reporting;response;Safety;safety assessment;Sampling;Secondary Prevention;Senile Plaques;Sleep;Sleep Deprivation;Sleep disturbances;sleep quality;Sleep Wake Cycle;Sleeplessness;Spinal Puncture;success;Synapses;synaptic function;Target Populations;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Transgenic Mice;treatment effect;Treatment Effectiveness;trial design;Venous;Wakefulness

PROJECT_TITLE: Effect of Suvorexant on Alzheimer's Disease Biomarkers

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative The limited success of clinical interventions in attention- deficit/hyperactivity disorder (ADHD) can be attributed to poor understanding of the neurobiological mechanisms that contribute to the heterogeneous set of behavioral dysfunctions associated with attention control. The proposed research will investigate how different stages of attention control– selection of sensory input, decision and motor responses are generated in the nervous system. These findings will advance basic understanding of specialized circuit elements of distinct components of top- down attention control leading to better defined diagnosis and more tailored therapeutic interventions of attention disorders.

PI_NAMEs: GHOSH, SUPRIYA  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Adaptive Behaviors;Animals;Anterior;Area;Arousal;Attention;Attention deficit hyperactivity disorder;attentional control;Behavior;Behavior Control;Behavioral;Brain;Brain Stem;Cerebral cortex;cingulate cortex;Classification;Clinical;Cognitive;cognitive control;Conflict (Psychology);Contralateral;Data;Diagnosis;Disease;Dissociation;Elements;environmental change;executive function;Feedback;flexibility;Functional disorder;Goals;Human;improved;Individual;insight;Intervention;Link;locus ceruleus structure;Measures;Mediating;Methods;Monitor;Monkeys;Motor;Nervous System;neurobiological mechanism;Neurobiology;Neurons;neurophysiology;neuroregulation;Noise;Norepinephrine;optogenetics;Pattern;Performance;Phase;Play;Prefrontal Cortex;Process;Psychology;Regulation;Research;Resources;response;Response to stimulus physiology;Role;selective attention;Sensory;sensory input;sensory stimulus;Stimulus;Structure;success;System;Testing;Therapeutic Intervention;therapeutic target;Training;Uncertainty;visual stimulus;Wakefulness;Work

PROJECT_TITLE: Isolating causal roles of norepinephrine neuromodulation in mediating distinct components of attention control

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prostate Cancer;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: NARRATIVE Surgical performance directly impacts patient outcomes. Prostate cancer, the most common cancer in men, is treated with surgery (robot-assisted radical prostatectomy (RARP)) that can lead to impotence, incontinence, and even death. Reliable means of objectively assessing robotic surgical skills are required. The proposed work will automate technical skills assessment, empowering surgeons with valuable knowledge to minimize prostatectomy surgical risk.

PI_NAMEs: HUNG, ANDREW  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;Assessment tool;automated assessment;Automobile Driving;Behavior;Benchmarking;Bladder Control;Cause of Death;Cessation of life;Characteristics;Classification;Clinical;clinically relevant;cognitive task;Computer Vision Systems;Consumption;cost;Data;Data Set;deep learning;deep learning algorithm;E-learning;empowerment;Environment;Exercise;Feedback;Gestures;Impotence;improved;Incontinence;innovation;instrument;kinematics;Knowledge;Label;Learning;learning network;learning strategy;Link;Machine Learning;machine learning algorithm;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Measurable;Measures;Medical Errors;men;Methods;Modality;Modeling;Motion;Movement;multimodal learning;Needles;novel;operation;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Patients;Performance;Positioning Attribute;predictive modeling;prospective;Prostatectomy;Publishing;Quality of life;Radical Prostatectomy;Recovery;Recurrence;Risk;robot assistance;Robotics;shot learning;skills;Statistical Models;Surgeon;surgery outcome;Surgical complication;Surgical Error;surgical risk;Surgical Specialties;Surgical sutures;task analysis;Technical Expertise;Techniques;Technology;Time;Tissues;Training;Travel;virtual coach;virtual reality;virtual reality simulation;virtual reality simulator;Vision;Work

PROJECT_TITLE: Automated Assessment for Robotic Suturing Utilizing Deep Learning Algorithms

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_CITY: VAN NUYS

ORG_NAME: MABSWITCH, INC.

PHR: Project Narrative: Downstream processing has remained a major bottleneck for the high-yield production of Lentiviral vectors owing to the intrinsic fragility of the virus that makes it highly susceptible to degradation and/or inactivation by the often harsh elution conditions that are required to desorb the lentivirus from the purification matrix. In this project, Mabswitch will develop LentiSAFE Ligands which are Switchable Affinity Mild-Elution immuno-affinity ligands based on a commercially available anti-lentivirus antibody, with the aim to assess the feasibility to purify functional lentiviral vectors from production supernatants under mild non-destructive conditions. Importantly owing to the universal character of the approach it will serve as a template for purification of many other fragile biotherapeutic reagents where immunoaffinity purification is currently not feasible.

PI_NAMEs: ONAKUNLE, YEMI  (contact)

PROGRAM_OFFICER_NAME: BROOKS, PJ

PROJECT_TERMS: Achievement;adeno-associated viral vector;Affinity;Affinity Chromatography;Allosteric Regulation;Antibodies;antigen binding;Antigens;Binding;Biological Response Modifier Therapy;Case Study;Clinical;Commercial grade;cost effective;Development;Equilibrium;Evolution;Future;Glycoproteins;Immobilization;Immune;immunoaffinity chromatography;Immunoglobulin Fragments;improved;In Vitro;Indiana;Laboratories;Lentivirus;Lentivirus Vector;Ligands;manufacture;Methods;Natural regeneration;novel;particle;Phase;Physiological;Predisposition;Process;Production;Reagent;Recovery;screening;Serotyping;Site;Small Business Innovation Research Grant;Sodium Chloride;Specificity;Standardization;Technology;Testing;Therapeutic;Tropism;Variant;vector;vesicular stomatitis virus G protein;Virus;Work

PROJECT_TITLE: LentiSAFE Ligands: Mild-Elution Immunoaffinity Ligands for Enrichment and Purification of Lentiviral Vectors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-F (10)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related

ORG_CITY: Newark

ORG_NAME: RNA THERAPEUTICS INC.

ORG_STATE: DE

PHR: PROJECT NARRATIVE The ongoing COVID-19 (coronavirus disease 2019) pandemic has made an unprecedented impact on global public health. The long-term goal of this project is to develop a broadly protective mRNA vaccines against current and emerging SARS-CoV-2 variants.

PI_NAMEs: HU, HAITAO  (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;Animals;Antibody Response;Antigens;Binding;Biotechnology;booster vaccine;Clinical;Clinical Trials;Communicable Diseases;COVID-19;COVID-19 pandemic;COVID-19 vaccine;cross immunity;cross reactivity;current pandemic;Data;Development;Early Diagnosis;efficacy evaluation;Future;Generations;Goals;Hamsters;Hand;Human;Immune Evasion;Immunity;Immunization;Immunize;immunogenic;Investigation;Laboratories;Length;Licensing;lipid nanoparticle;manufacture;Mediating;Medical;Mesocricetus auratus;Messenger RNA;mRNA lipid nano particle vaccine;Mus;novel;Nucleocapsid Proteins;pandemic disease;Phase;Population;prevent;product development;protective efficacy;Proteins;Public Health;Recurrence;Regimen;Reporting;research clinical testing;response;RNA vaccine;Safety;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.617.2;SARS-CoV-2 variant;Secondary Immunization;Small Business Technology Transfer Research;T-Lymphocyte;Technology;Texas;Therapeutic;therapeutic RNA;Toxic effect;transmission process;Universities;Vaccinated;Vaccination;vaccine candidate;vaccine delivery;vaccine development;vaccine efficacy;vaccine platform;Vaccines;Variant;variants of concern;Viral;Viral Proteins

PROJECT_TITLE: Development of a Pan-COVID-19 Vaccine Candidate

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-D (10)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Genetics;Prevention;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE This proposal provides a timely response to an environmental accident and chemical exposure in East Palestine, Ohio by initiating community engagement participatory research, providing context with qualitative research approaches, and establishing a baseline biospecimen repository. The utility of novel biomarkers for chemical-wide exposures establishes a new paradox for environmental exposure assessment and health changes. The community engagement establishes a cornerstone for continued and future research determining long-term health impacts, as well as establishing a two-way relationship between community members and health researchers.

PI_NAMEs: SCHUMACHER, FREDRICK RAY (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Accidents;Acrylates;Acute;Advocacy;Advocate;Affect;Age;Air;air sampling;Area;Atmosphere;Autoimmune Diseases;Binding;Biological Assay;Biological Markers;Biological Specimen Banks;Blood;Carcinogens;Cessation of life;Chemical Exposure;Chemicals;Chronic;chronic liver disease;Classification;cohort;Collection;Communities;community advisory board;community engaged research;community engagement;Community Outreach;community research;Consent;Coping Skills;Cross-Sectional Studies;Data;Dioxins;Disasters;Disease Surveillance;disorder risk;DNA;DNA Adducts;DNA Damage;Environment;environmental chemical exposure;Environmental Exposure;Environmental Health;Environmental Impact;Epidemiologist;Epigenetic Process;experience;Family;Fishes;Foundations;Future;genomic biomarker;genotoxicity;Geography;Hazardous Chemicals;Health;health care delivery;Healthcare;Heavy Industries;Hour;Human;Hydrogen Chloride;Individual;innovation;Institution;International Agency for Research on Cancer;Interview;Kidney Diseases;Link;Location;Longitudinal Studies;Malignant neoplasm of liver;Measures;member;Monitor;Mutation;Nature;novel;novel marker;Occupational;Ohio;Outcome;outreach;Phosgene;Poison;pollutant;Prospective cohort;Proxy;Public Health;Qualitative Research;Quality of life;Radial;Reaction Time;recruit;Research;Research Personnel;Research Proposals;research study;residence;Resources;response;Risk;risk perception;Running;Sampling;sex;Shapes;Site;Somatic Mutation;Stream;stressor;Structure;Surface;Surveys;Testing;Time;Toxic effect;Toxin;Training;transcriptomics;Urine;Vinyl Chloride;Voice;Water;Work

PROJECT_TITLE: Healthy Futures Research Study: Linking somatic mutation rate with baseline exposure in East Palestine

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-D (TS)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative The proposed research is relevant to public health because the mycobacterial genes and pathways that promote interactions with the host during infection are potential targets for the development of new vaccines and therapeutics which would help to lessen tuberculosis. This research is relevant to NIH’s mission because defining mycobacterial virulence that promote survival during infection will contribute fundamental knowledge, which will be applicable to tuberculosis prevention, diagnosis and treatment.

PI_NAMEs: CHAMPION, PATRICIA A (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: active control;Bacteria;Bacteriolysis;Cells;Cessation of life;combat;Coupled;Cytoplasm;Development;Diagnosis;Environment;Experimental Designs;Genes;genetic approach;Genetic Screening;Genus Mycobacterium;Goals;Growth;Immune response;Infection;Infection Control;Inflammasome;innovation;Knowledge;Listeria monocytogenes;Macrophage;Measures;Membrane;Mission;Molecular;mutant;mycobacterial;Mycobacterium marinum;novel;novel therapeutics;novel vaccines;overexpression;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Phagocytes;Phagosomes;prevent;Prevention;protective pathway;Public Health;Reporter;Research;System;Testing;Time;Tuberculosis;United States National Institutes of Health;Virulence;Virulence Factors

PROJECT_TITLE: Identifying the mycobacterial genes controlling bacteriolysis in the macrophage cytoplasm

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-P (02)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Immunization;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: POTTSTOWN

ORG_NAME: ABZYME THERAPEUTICS, LLC

ORG_STATE: PA

PHR: NARRATIVE. Novel multi-specific antibodies for treatment of retinal neovascular diseases will be produced. Multi-target long-acting therapy will represent a major improvement in comparison with the current anti-VEGF monospecific treatment, as it covers a broader spectrum of retinal neovascular disease patients with less frequency of dosing.

PI_NAMEs: TRAN, HIEP T (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: 3-Dimensional;Affinity;Age;Amino Acids;Angiogenesis Inhibitors;Angiogenic Factor;Animal Model;Animals;antiangiogenesis therapy;Antibodies;Antibody Formation;Antibody Therapy;Binding;Biological;Biological Assay;Cell Culture Techniques;Cell Line;Cells;Chinese Hamster Ovary Cell;Choroidal Neovascularization;Collaborations;commercialization;comparison control;Data;Development;diabetic;Disease;Dose;drug candidate;Endophthalmitis;established cell line;Extravasation;Exudative age-related macular degeneration;Eye;Eye diseases;Fab Immunoglobulins;Frequencies;Gel;Goals;Half-Life;Healthcare;Human;humanized antibody;Hyaluronan;Immunoglobulin G;improved;In Vitro;in vitro Assay;in vivo;Injections;interest;large scale production;Lasers;Lesion;Lucentis;macular edema;Mammalian Cell;Manufacturer;Matrix Metalloproteinases;Medical;Modeling;Molecular;mouse model;Mus;nanobodies;neovascular;neovascularization;novel;Outcome;Pathogenesis;Patients;Peptide Phage Display Library;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Physicians;Plant Resins;Population;Positioning Attribute;Production;Proteins;Protocols documentation;ranibizumab;Recombinants;Reporting;Retina;Retinal Neovascularization;Retinal Vein Occlusion;Risk;South Carolina;stable cell line;targeted treatment;Therapeutic;Time;Toxic effect;Treatment Efficacy;Tube;Universities;Uveitis;Validation;Vascular Diseases;Vascular Endothelial Growth Factors;Vision;Vitreous Hemorrhage

PROJECT_TITLE: Multi-specific long-acting antibodies for the treatment of retinal neovascular diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-M (12)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: DURHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE  According to the World Health Organization, in 2019 three of the top ten causes of death were respiratory diseases, contributing to over 8 million deaths every year. The proposed research will investigate the molecular mechanisms underlying cell identity in the alveolar epithelium, which will provide crucial insights into how lung tissue properly repairs itself during regeneration, and how this process contributes to fibrosis when it goes awry. The results of these studies will provide key insights into the basic biology of molecular determinants of cellular identity, and open avenues for the development of therapeutics that can improve the lives of the millions of patients living with respiratory disease.

PI_NAMEs: MOROWITZ, JEREMY  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Address;adenovirus mediated delivery;Alveolar;alveolar epithelium;Biology;Cause of Death;Cells;Cessation of life;Cicatrix;Coculture Techniques;connective tissue growth factor;Data;Diagnosis;Disease;Ectopic Expression;effective therapy;Epithelial Cells;epithelial injury;Epithelium;Event;Extracellular Matrix;Fibroblasts;Fibrosis;fibrotic lung;Functional Regeneration;Galectin 3;Genetic Models;Goals;Human;improved;In Vitro;in vivo;Industrialization;Injury;insight;interstitial;Knowledge;loss of function;Lung;Lung Diseases;lung failure;lung injury;MDM2 gene;Modeling;Molecular;Molecular Biology;mutant;Myofibroblast;Natural regeneration;novel;novel therapeutics;Pathogenesis;Pathologic;Pathway interactions;Patients;Pliability;Process;Pulmonary Fibrosis;recombinase;Regulation;repaired;Research;Respiratory Disease;Role;Societies;stem cells;Structure of parenchyma of lung;Terminal Disease;Testing;therapeutic development;Tissues;TP53 gene;transcription factor;transcriptomic profiling;transcriptomics;Transitional Cell;Transitional Epithelium;Translational Research;ubiquitin-protein ligase;Up-Regulation;Work;World Health Organization

PROJECT_TITLE: Determining the role of TP53 regulation in alveolar epithelial transitional cell state,  and the contribution of alveolar epithelial transitional cell state to pulmonary fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Liver Disease;Mental Health;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: The East Palestine, OH train derailment resulted in a significant spill of volatile organic compounds including the hepatotoxicant vinyl chloride (VC), impacting a community of 5000 people and multiple environmental media. Given the volatile nature of the contaminants and the high level of stress in the community, it is critical to collect and bank time-sensitive environmental media- and biospecimen data, as well as actively characterize and address the growing psychosocial stressors. We propose to use a citizen science approach, engaging the community from design through dissemination.

PI_NAMEs: BEIER, JULIANE I (contact);LICHTVELD, MAUREEN Y.

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Acids;Address;Air;air sampling;biobank;Biological Markers;Biological Specimen Banks;Blood;Cardiometabolic Disease;chemical spill;Chemicals;Chronic;Cirrhosis;citizen science;cohort;Cohort Studies;Collaborations;Collection;Communities;community collaboration;community engaged approach;community engagement;Community Health;Cytokeratin-18 Staining Method;Data;data repository;design;Devices;Disasters;Drainage procedure;drinking water;Emergency Situation;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Impact;Exposure to;Fibrosis;Future;Genomic DNA;ground water;Health;health data;Hemangiosarcoma;Hepatic;hepatotoxin;Home;Human;Income;Individual;indoor air;indoor exposure;Inflammation;Information Dissemination;innovation;instrument;Investigation;leukemia;Liver diseases;liver injury;Long-Term Effects;Lymphoma;Malignant neoplasm of brain;Malignant neoplasm of lung;Maps;Measures;member;Municipalities;Nature;Non-Malignant;Occupational Exposure;Organ;Outcome;Participant;Pattern;Persons;Plasma;Poly-fluoroalkyl substances;Population Characteristics;Poverty;Primary carcinoma of the liver cells;psychosocial;Psychosocial Stress;psychosocial stressors;Research Design;Residential Mobility;Resources;Risk;Risk Factors;Sampling;Serum;Site;Soil;Steatohepatitis;Stream;Stress;stressor;study population;Surface;Time;toxicant;Training;Trust;underserved community;Universities;Urine;Veterans;Vinyl Chloride;volatile organic compound;Volatilization;Vulnerable Populations;Water;water sampling;well water

PROJECT_TITLE: East Palestine Community-Engaged Environmental Exposure, Health Data, and Biospecimen Bank


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Opioids;Osteoarthritis;Pain Research;Prevention;Rehabilitation;Sleep Research

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Total Knee Arthroplasty (TKA) is the most common elective surgical procedure in the US with up to 40% of patients reporting some degree of chronic post-surgical pain and 13% of opioid naïve patients continuing use of opioids 1-year after surgery. Insomnia impacts 50% of TKA patients and is increasingly identified as a perioperative risk factor for chronic post-surgical pain and opioid misuse, but it is not known whether treating insomnia perioperatively reduces chronic post-surgical pain and opioid consumption. This randomized controlled trial in patients undergoing TKA, tests the effects of perioperative cognitive-behavioral therapy for insomnia (CBTi) and CBTi + morning bright light treatment on chronic post-surgical pain and opioid consumption.

PI_NAMEs: BURGESS, HELEN JULIA;SMITH, MICHAEL T (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Acute;Agonist;Analgesics;arm;Behavior;Behavioral;Benzodiazepine Receptor;Central Nervous System;Chronic;Chronic Insomnia;chronic pain;circadian;Circadian Dysregulation;Circadian Rhythms;clinical pain;Clinical Trials;clinically significant;cognitive enhancement;Cognitive Therapy;coping;cost;Dangerousness;Data;Degenerative polyarthritis;Depressed mood;Development;Education;Elective Surgical Procedures;Epidemic;experience;fall risk;Flare;health care service utilization;High Prevalence;high risk;Hour;hypnotic;Impairment;improved;improvement on sleep;Individual;Intervention;Ions;Knee Osteoarthritis;knee replacement arthroplasty;Link;Mediating;Melatonin;Meta-Analysis;modifiable risk;Moods;Napping;negative mood;novel strategies;older adult;Operative Surgical Procedures;Opioid;opioid abuse;opioid exposure;opioid misuse;opioid sparing;opioid use;Orthopedic Procedures;Outcome;Pain;pain chronification;Pain management;pain reduction;pain sensitivity;Patients;Perioperative;Pharmacotherapy;Phototherapy;Placebos;Postoperative Pain;preclinical study;prescription opioid;prevent;Property;prospective;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Recovery;Reporting;Research;Rest;Risk;Risk Factors;sedative;Severities;Sleep;Sleep disturbances;Sleeplessness;standard care;statistics;Stress;surgical pain;Symptoms;systemic inflammatory response;telehealth;Testing;theories;treatment effect;Work

PROJECT_TITLE: Adding Bright Light Treatment to Cognitive-Behavioral Therapy for Insomnia to Prevent Chronic Post-Surgical Pain in Older Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-Y (02)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Agent Orange & Dioxin;Endocrine Disruptors;Health Effects of Indoor Air Pollution;Physical Injury - Accidents and Adverse Effects;Prevention

PHR: Project Narrative  On February 3rd, 2023, a train derailment caused a fast-moving contamination event that spread chemicals and their combustion by-products through the surrounding region, impacting multiple communities including the immediate evacuation areas in a one-mile by two-mile area surrounding East Palestine, OH, as well as other communities in Columbiana and Beaver Counties. This project aims to determine the post- accident exposome profiles in the impacted communities by collecting soil, water, and sediment samples and conducting both targeted and non-targeted analyses on the persistent combustion byproducts, as well as performing a model-based comprehensive evaluation of long-term environmental fate, human exposure levels, and corresponding health risks of all the quantified contaminants in the exposome profile. The project is time- sensitive due to its urgent need for sample collections, and the results will provide critically needed data on a broad suite of contaminants that can currently impact human health in the affected regions, empowering key stakeholders to make informed decisions about exposure interventions and remediation.

PI_NAMEs: FABISIAK, JAMES P (contact);GAO, PENG

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Accidents;Acrylates;Affect;Air;Area;Aromatic Polycyclic Hydrocarbons;Atmosphere;Benzene;bioaccumulation;chemical accident;chemical release;Chemicals;Chronic;combustion product;Communities;Computer Models;County;Data;design;Dioxins;Disasters;Emergency Situation;empowerment;Ensure;Environment;Environmental Exposure;Environmental Monitoring;Evaluation;Event;Explosion;exposed human population;Exposure to;Fire - disasters;Fishes;Fuel Oils;Furans;Gasoline;Health;Human;Intervention;liquid chromatography mass spectrometry;Livestock;Malignant Neoplasms;Mass Fragmentography;Measures;Modeling;Municipalities;Names;Near East;Ohio;Oils;Pathway interactions;Pennsylvania;Plastics;Polychlorinated Biphenyls;prevent;Production;remediation;Reporting;Resolution;Risk;Risk Assessment;Rupture;sample collection;Sampling;screening;Soil;Source;Time;Training;Transportation;Vinyl Chloride;Water;water sampling

PROJECT_TITLE: Profiling the Post-accident Exposome in East Palestine


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: WEST LAFAYETTE

ORG_NAME: TYMORA ANALYTICAL OPERATIONS, LLC

PHR: PROJECT NARRATIVE Early non-invasive detection of Alzheimer's disease is the top priority for successful treatment and disease monitoring. However, no effective wide-spread early diagnostics assay is currently available. This NIH SBIR Phase II project will support the continued efforts to develop and validate a new non-invasive plasma-based diagnostic assay for early detection of Alzheimer's disease.

PI_NAMEs: ILIUK, ANTON  (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: Academic Medical Centers;Address;Affinity;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease diagnosis;Alzheimer's disease diagnostic;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;American;Amyloid beta-Protein;Attention;Biological Assay;Biological Markers;biomarker discovery;biomarker panel;blood-brain barrier crossing;Brain;Cell secretion;Characteristics;CLIA certified;Clinical;Clinical Chemistry;Clinical effectiveness;clinically relevant;cohort;Collection;Consensus;Consumption;cost;cost effective;Detection;detection assay;diagnostic assay;Disease;Disease Marker;Disease Progression;disorder control;Early Diagnosis;early screening;Effectiveness;empowerment;Ensure;Enzyme-Linked Immunosorbent Assay;Evaluation;exosome;experimental study;extracellular vesicles;FDA approved;Goals;Hand;hydrophilicity;instrument;Link;Lipids;lipophilicity;liquid biopsy;Machine Learning;Marketing;Methods;mild cognitive impairment;minimally invasive;Monitor;Names;Nature;Nerve Degeneration;Neurologic;Neurons;Non-Invasive Detection;novel;novel marker;Patients;Performance;Phase;phase 2 study;Plasma;Plasma Proteins;Positron-Emission Tomography;potential biomarker;Procedures;protein biomarkers;Proteins;Public Health;Recovery;Reporting;Reproducibility;Research;Sampling;screening;Services;Signal Transduction;Site;Small Business Innovation Research Grant;Source;Spinal Puncture;success;tau Proteins;Techniques;Testing;Time;Translating;Ultracentrifugation;United States;United States National Institutes of Health;Validation

PROJECT_TITLE: Validation and clinicaldevelopment of plasma EV protein biomarkers for minimally-invasive detection of Alzheimersdisease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-G (13)]


NIH_SPENDING_CATS: Bioengineering;Chronic Obstructive Pulmonary Disease;Chronic Pain;Lung;Neurosciences;Pain Research;Palliative Care

ORG_CITY: Irvine

ORG_NAME: SCIENTIFIC HORIZONS CONSULTING LLC

PHR: Project Narrative Treating inflammation in deep lung targeting distal airways represents an important avenue for managing pain in chronic obstructive pulmonary disease (COPD), however, current forms of anti- inflammation inhalation therapies are ineffective due to multiple challenges, including significant side effects, low pulmonary delivery efficiencies, hard-to-use hand-breath coordination user interfaces and the lack of dose monitoring/control systems. This proposal seeks to develop a novel aerosolization platform with the inhalation device prototype combined with the condensation aerosolization atomizer and optimized formulations for the effective, efficient, and dose-controlled pulmonary delivery of anti- inflammatory agents, corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs), to the deep lung. This innovative technology platform has the potential to shift the paradigm from traditional inhaler and nebulizer strategies for inflammation and pain management in COPD and other inflammatory respiratory diseases.

PI_NAMEs: GAO, XIANG  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: 3-Dimensional;Acute;acute toxicity;Adherence;Adrenal Cortex Hormones;aerosolized;Aerosols;Afferent Neurons;airway inflammation;Algorithms;Anti-Inflammatory Agents;Applications Grants;Atomizer;Authorization documentation;Categories;Cell model;Cell Survival;Chemicals;Chronic Obstructive Pulmonary Disease;chronic pain;Coculture Techniques;commercialization;Consumption;cytokine;cytotoxicity;Data;Deposition;Devices;Diameter;Disadvantaged;Distal;dosage;Dose;dosimetry;Effectiveness;efficacy evaluation;Endothelial Cells;Epithelium;evaporation;Formulation;Future;Gene Expression;Goals;Guidelines;Hand;Hand functions;Human;Ibuprofen;Immune;improved;In Vitro;individualized medicine;ineffective therapies;Inflammation;Inflammatory;inflammatory pain;Inhalation;Inhalation Device;Inhalation Therapy;Inhalators;innovation;innovative technologies;insight;Investigation;Learning;Lung;Macrophage;Medicine;Membrane;meter;Modeling;Monitor;monocyte;Mucins;Nebulizer;Nociceptors;Non-Steroidal Anti-Inflammatory Agents;novel;opioid use;Oral Administration;Pain;Pain management;pain reduction;particle;Particle Size;Patients;Pharmaceutical Preparations;Phase;Phenotype;Physical condensation;Physicians;point of care;prototype;Proxy;Reaction;Recommendation;Regimen;respiratory;Respiratory Disease;Respiratory System;Risk;side effect;Small Business Innovation Research Grant;Stimulus;System;Technology;technology platform;Temperature;Therapeutic;Time;tissue culture;Toxic effect;treatment duration

PROJECT_TITLE: A Novel Aerosolization and Inhalation Platform for the Pulmonary Delivery of Anti-inflammatory Agents to Distal Airways for the Enhanced Pain Management in Chronic Obstructive Pulmonary Disease (COPD)


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Despite the clinical benefits of AAV ocular gene therapy vectors, inflammation and toxicity have been reported in some patients, at times resulting in visual deterioration. Prior literature and unpublished data suggest a role for dsRNA-mediated ocular toxicity of AAV vectors, which we will test directly in this proposal. Our data suggest that there are other pathways as well that contribute to toxicity, so we will leverage an unbiased spatial transcriptomics approach (Light-Seq) paired with functional readouts to identify and validate pathways mediating toxicity, expanding our understanding of antiviral responses to AAV in the eye.

PI_NAMEs: GARDNER, APOLONIA  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: adeno-associated viral vector;Affect;Alleles;Anti-viral Response;Area;Blindness;CCRL2 gene;cell type;Cells;cellular transduction;Clinical;Cone;confocal imaging;Coupled;Cytomegalovirus;Data;delivery vehicle;Dependovirus;Deterioration;Development;differential expression;Dissociation;Dose;Double-Stranded RNA;Engineering;Exhibits;experimental study;Eye;Eye diseases;FDA approved;Fluorescent in Situ Hybridization;follow-up;Gene Expression;gene therapy;Gene Transduction Agent;Genes;Genetic;Genetic Diseases;Genetic Transcription;Immune;Immune response;Immunofluorescence Immunologic;improved;In Vitro;in vivo;Inflammation;Inherited;insight;Inverted Terminal Repeat;Knock-out;Knockout Mice;Knowledge;Leber's amaurosis;Light;Literature;Mediating;Methods;Morphology;Mus;Mutation;Natural Immunity;nonhuman primate;Organ;Pathway interactions;Patients;Persons;pharmacologic;Photoreceptors;promoter;Recording of previous events;Reporting;response;Retinal Diseases;retinal toxicity;rho;RNA;Role;Sampling;sensor;Signal Pathway;Signal Transduction;Source;Structure of retinal pigment epithelium;subretinal injection;success;Suggestion;Testing;Therapeutic;Tissues;Toxic effect;Transcript;transcriptomics;transduction efficiency;vector;Visual

PROJECT_TITLE: Elucidating Host Responses to AAV Ocular Gene Therapy Vectors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Prevention

ORG_CITY: REDMOND

ORG_NAME: VERAVANTI, INC.

ORG_STATE: WA

PHR: NARRATIVE Tooth decay (or dental caries) is a health condition which affects 3.5 billion people annually and which primarily arises from bacterial infection from the biofilms that cover the teeth. VerAvanti intends to develop a clinically safe Optical pH device which introduces an acid-measurement technique that relies on pH-sensitive fluorescence dye as a means to detect, and even predict, locations of future demineralization and caries. This will allow dentists to determine where there is the highest risk of tooth decay, providing feedback to both the dentist and the patient as to the level of enamel health, and guide the dentist in therapeutic actions to prevent future cavities.

PI_NAMEs: MCMORROW, GERALD  (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: Acceleration;Acids;Address;Adult;Affect;Area;Bacteria;Bacterial Infections;Bite;Buffers;Calibration;Case Study;Characteristics;Child;Clinic;Clinical;Clinical Protocols;Clinical Research;Collaborations;Color;Computer software;cost effectiveness;Custom;demineralization;Dental;Dental caries;Dental Clinics;Dental Enamel;Dental Hygiene;Dental Offices;Dental Plaque;Dental Research;Dentin;Dentists;design;Detection;Development;Devices;Diet;Drops;Dyes;Electrodes;Environment;Evolution;extracellular;Extracellular Matrix;fabrication;Failure;FDA approved;Feedback;Fluorescein;Fluorescence;Fluorescent Dyes;Fostering;Funding;Future;future implementation;Future Teacher;Growth;Health;high resolution imaging;high risk;Human;human subject;Image;image processing;imaging modality;imaging system;improved;in vitro testing;in vivo;in vivo imaging;instrument;Lasers;Left;Light;Location;manufacturability;Maps;Marketing;Measurement;Measures;Medical;meter;Methods;Microbial Biofilms;operation;Operative Surgical Procedures;optical imaging;Optics;oral biofilm;Oral cavity;Pain;Patients;Performance;Persons;Phase;phase 1 testing;photonics;Physiological;Pilot Projects;portability;prevent;Prevention;Preventive treatment;Procedures;Process;product development;Production;prototype;Publishing;ratiometric;Reading;Reporting;Reproducibility;Research;research faculty;Resolution;Safety;Saliva;School Dentistry;Severities;Site;Sodium Fluorescein;Speed;Study Subject;sugar;Surface;Surveys;Techniques;temporal measurement;Testing;Therapeutic;Thick;Time;Tooth Demineralization;Tooth Loss;Tooth structure;tooth surface;Uncertainty;Universities;usability;visual information;Washington;young adult

PROJECT_TITLE: Development of Quantitative In Vivo Imaging of Oral Biofilm pH to Allow Prevention of Enamel Demineralization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (10)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: We aim to understand the biophysical mechanisms that enable the distinct intrinsic dynamics of dopamine (DA) neuron subpopulations that project to distinct targets by a combination of modeling and in vivo/in vitro experimental strategies. We focus on how intrinsic dynamics differ between defined DA subpopulations, and how those differences shape the integration of synaptic input within the circuit, including newly identified modes of burst generation in DA neurons in vivo: plateau bursting and rebound bursting. A better understanding of the intrinsic properties of distinct subpopulations of dopamine neurons will be invaluable in targeting therapies for disorders with abnormal dopamine signaling, such as substance abuse disorders, Parkinson’s disease and schizophrenia.

PI_NAMEs: CANAVIER, CARMEN CASTRO (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Affect;Anesthesia procedures;Association Learning;Axon;Basal Ganglia;Behavior;Binding;Biophysical Process;Categories;cholinergic;Closure by clamp;Computer Models;Corpus striatum structure;Data;Dendrites;Dialysis procedure;Disease;Disinhibition;Distal;Dominant-Negative Mutation;Dopamine;dopaminergic neuron;Electrophysiology (science);Exhibits;expectation;experimental study;extracellular;fibroblast growth factor 13;Frequencies;Generations;genetic manipulation;Head;Impairment;In Vitro;in vivo;inhibitor;insight;Interruption;Intervention;Ion Channel;knock-down;Kv4 channel;Lateral;Learning;markov model;Mathematics;Medial;Midbrain structure;Modeling;Molecular;Morphology;motivated behavior;Motivation;Movement;Mus;Muscarinic Agonists;Neurons;Nonlinear Dynamics;Nose;Nucleus Accumbens;Pacemakers;Parkinson Disease;patch clamp;Pattern;Peptides;pharmacologic;Phase;Phenotype;Population;population based;Property;Ramp;response;Rewards;Role;Schizophrenia;sequence learning;Shapes;Signal Transduction;Small Interfering RNA;Substance abuse problem;Substantia nigra structure;Synapses;targeted treatment;Testing;Time;virtual

PROJECT_TITLE: A Dynamic Diversity of Dopamine Neurons

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: NARRATIVE The environmental disaster in East Palestine, Ohio following the train derailment and controlled burn in February 2023 caused immediate concerns for air quality and respiratory hazards. Preliminary mobile air sampling data support continued spatial and temporal characterization of volatile organic compound mixtures to identify hot spots and apprise known and unknown chemicals of concern that may volatilize from remediation processes. Continued air sampling coupled with AI-based tools enabling community health assessment and environmental exposure and sensitivity analysis directly inform hyperlocal air quality issues and residential health concerns following an environmental disaster that may exert long-term impacts on community health.

PI_NAMEs: JOHNSON, NATALIE M (contact)

PROJECT_TERMS: Acrolein;Active Sites;Acute;Address;Air;air monitoring;Air Pollution;air sampling;Area;Assessment tool;Atmosphere;Benzene;chatbot;Chemical Exposure;chemical spill;Chemicals;Collaborations;Communication;Communication Tools;Communities;Community Health;Community Surveys;Coupled;Data;Data Collection;Data Reporting;Disasters;Emergency response;Emergency Situation;Environmental Epidemiology;Environmental Exposure;Environmental Health;epidemiology study;Equipment and supply inventories;Event;experience;Exposure to;Funding;Funding Mechanisms;Future;Goals;Government;hazard;Hazardous Chemicals;Hazardous Substances;Health;health assessment;health data;Hot Spot;Human;Hurricane;Individual;Infrastructure;Inhalation Toxicology;innovation;Institution;irritation;Laboratories;Longitudinal trends;Measurement;Mental Health;Methods;Mission;Monitor;Near East;North Carolina;novel;Ohio;Outcome;particle;Patient Self-Report;Phase;physical conditioning;Process;Protons;Psychophysiologic Disorders;public health emergency;Reaction Time;Recovery;remediation;Reporting;Research;Research Personnel;Resolution;Resources;respiratory;response;Risk;Risk Assessment;Sampling;Science;Scientist;Sensory;Site;spatiotemporal;stressor;Superfund;Survey Methodology;Surveys;Symptoms;temporal measurement;Texas;Text Messaging;Time;time of flight mass spectrometry;Toluene;tool;Training;Universities;Variant;volatile organic compound;Volatilization;Work;Xylene

PROJECT_TITLE: Responding to air pollution in disasters (RAPID) air sampling and symptom monitoring in East Palestine, OH


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: NARRATIVE. Several cancer treatment modalities involve the DNA damage response, and furthermore mutations and chromosomal rearrangements are hallmarks of cancer. The 2024 Gordon Research Conference on DNA Damage, Mutation and Cancer will focus on cutting-edge research on defining basic mechanisms of the DNA damage response and leveraging this information for translational research on cancer biomarkers and therapeutics. Thus, this conference will support the mission of the NIH to improve cancer treatments and patient outcomes.

PI_NAMEs: STARK, JEREMY MICHAEL (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Area;Basic Science;Biological Markers;Biotechnology;black women;Botanicals;Brain;Cancer Biology;cancer biomarkers;Cancer Etiology;cancer therapy;career;career development;Chromosomal Rearrangement;commune;Communities;Country;Dedications;Development;Discipline;DNA biosynthesis;DNA Damage;DNA Repair;DNA-Directed DNA Polymerase;Equilibrium;Event;Faculty;Female;forging;Fostering;Goals;grasp;Growth;Hour;Immune signaling;Immune system;improved;Individual;Industry;International;Knowledge;Laboratories;Leisure Activities;Life;Location;Los Angeles;Malignant Breast Neoplasm;Malignant Neoplasms;Marketing;meetings;Mentors;Mentorship;Mission;Modality;Mutagenesis;Mutation;Neoplasm Metastasis;Nerve Degeneration;new technology;novel strategies;outreach;Paper;Patient-Focused Outcomes;Physicians;Policies;Poly(ADP-ribose) Polymerase Inhibitor;Population;Postdoctoral Fellow;posters;professor;programs;Publishing;Radiation therapy;Research;Research Personnel;response;Schedule;Science;Scientist;Senior Scientist;social;structural biology;symposium;Therapeutic;Time;Training;Translational Research;Treatment outcome;Underrepresented Populations;United States National Institutes of Health;Variant;Woman;Work

PROJECT_TITLE: 2024 DNA Damage, Mutation and Cancer Gordon Research Conference and Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (O1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Social Determinants of Health

ORG_CITY: FRAMINGHAM

ORG_NAME: OUTCOME REFERRALS INC

PHR: PROJECT NARRATIVE  Hundreds of thousands of children were confirmed victims of maltreatment in the United States in 2017. In that same year, of the 442,733 children in foster care, approximately one out of 10 were placed in a group home or institution. Out-of-home placement decisions have extremely high stakes for the present and future well-being of these vulnerable children because some placements, and multiple placements, are associated with poor outcomes. The likelihood of success recommendations provided by the proposed “Placement Success Predictor” tool will help placement staff and administrators identify the best placement setting for each child using machine-learning statistics to predict the child’s chances of success in each potential treatment setting.

PI_NAMEs: TRUDEAU, KIMBERLEE JEAN (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Administrator;Adolescent;behavioral health;Brain imaging;care coordination;care costs;Caring;Characteristics;Child;Child Care;Child Welfare;Client;Clinical;clinical decision-making;clinical predictors;cost;Custom;Data;data curation;Data Set;Databases;Decision Making;Development;Effectiveness;efficacy evaluation;Family;flexibility;foster care;Funding;Future;Gatekeeping;Grant;Group Homes;Health Care Costs;health organization;Healthcare;Home;implementation barriers;improved;Individual;innovation;Institution;Justice;Kidney;Machine Learning;machine learning algorithm;machine learning model;machine learning prediction;maltreatment;Managed Care;Medicine;Mental Health Services;Methodology;Modeling;models and simulation;Operative Surgical Procedures;Outcome;Patient Self-Report;Patients;Personal Satisfaction;personalized predictions;Phase;Population;predictive modeling;predictive tools;Prevention;Probability;programs;prototype;Psychiatric therapeutic procedure;Quasi-experiment;randomized, clinical trials;Recommendation;Reporting;Residential Treatment;Resources;Risk;Risk Adjustment;severe mental illness;Site;Small Business Innovation Research Grant;Source;statistics;Structure;success;support tools;Surgeon;System;Team Nursing;Techniques;Testing;tool;Treatment outcome;treatment program;United States;United States National Institutes of Health;Update;usability;Youth

PROJECT_TITLE: Placement Success Predictor: Using Site-Customized Machine Learning Models to Predict the Best Level of Care Placement for Each Child's Behavioral Health Needs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (10)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Multiple sclerosis (MS) is one of the most prevalent (~1 million MS patients in the US) and debilitating neurological diseases that affects patients in early adulthood and is the second leading cause of non-traumatic paralysis. In the brain, in MS, hallmark signatures derived from susceptibility weighted MRI (SWI) have provided insight into the biogenesis, evolution, and improved diagnostic specificity of the disease but SWI has even shown utility beyond MS for detecting and quantifying iron accumulation, vascular leakage, microbleeds, and traumatic injury. SWI of the spinal cord is understudied, but if optimized, deployed, and validated in MS, identifying similar hallmarks as seen in the brain would 1) provide insight into MS disease, 2) provide a tool that can be utilized in the spinal cord for other conditions and 3) address a knowledge gap of quality, vetted, SWI for the human spinal cord in vivo.

PI_NAMEs: SMITH, SETH A (contact)

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;American;Anterior;Autopsy;Benchmarking;Biogenesis;Biological Markers;Blood Vessels;Brain;Central Vein;Cervical spinal cord structure;Clinical;clinical translation;clinically relevant;cohort;Consensus;contrast enhanced;Data;design;Development;Diagnostic;Diagnostic Specificity;Diffuse Axonal Injury;Disease;Disease Marker;Disease susceptibility;emerging adult;Enrollment;Evaluation;Evolution;expectation;Extravasation;future implementation;Gender;Goals;healthy volunteer;Hemorrhage;Human;Image;improved;in vivo;Infection;Inflammation;Injury;insight;Iron;Ischemia;Knowledge;Lesion;Literature;Magnetic Resonance Imaging;malformation;Morphologic artifacts;Motion;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;Nerve Degeneration;Nervous System Disorder;Paralysed;Pathologic;Pathology;Patients;Physiological;Play;Predisposition;Prevalence;Process;Radiology Specialty;Relapsing-Remitting Multiple Sclerosis;Research;research clinical testing;Resolution;Role;Scanning;Site;Slice;specific biomarkers;Spinal;Spinal Cord;spinal cord compression;Structure;success;Techniques;Time;tool;Translating;Trauma;Traumatic injury;Validation;vascular abnormality;Veins;Vendor;Venous;white matter;Work

PROJECT_TITLE: Development of Susceptibility Weighted MRI for the Human Spinal Cord

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project narrative Our lab has published that an agonistic TLR4/MD2 antibody (TLR4-Ab) successfully reverses acute T1D in diabetic mice, activates myeloid derived suppressor cells, and has prolonged endosomal sequestration. However, the mechanism by which TLR4-Ab can reverse T1D is still unclear. Our proposed study will determine the role of TLR4-Ab structure, which downstream TLR4 signaling is important for MDSC differentiation, and begin the translation of this therapy from mice to humans by studying novel human anti- TLR antibodies.

PI_NAMEs: SWEENEY, NICOLLE  (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Acute;Acute Disease;Adoptive Transfer;Agonist;Antibodies;Antibody Therapy;autoimmune pathogenesis;Avidity;Binding;Biological Assay;Cell Differentiation process;Cell Maturation;Cell surface;Cells;Chronic Disease;clinical effect;Clinical Trials;Cryoglobulins;cytokine;Data;Development;Diabetes Mellitus;diabetes mellitus therapy;Diabetes prevention;diabetic;Diabetic Ketoacidosis;Diabetic mouse;Disease;Endosomes;Generations;glycosylation;Human;Hyperglycemia;IgG1;IgG3;IgG4;Immobilization;Immune;Immunoglobulin Class Switching;Immunologist;immunoregulation;Immunotherapy;in vivo;Inbred NOD Mice;Inflammation;innate immune pathways;Insulin;Insulin-Dependent Diabetes Mellitus;IRF3 gene;Length;Life;Ligands;Mediating;mouse model;Mus;Myeloid Cells;Myeloid-derived suppressor cells;Myelopoiesis;new therapeutic target;NFKB Signaling Pathway;Nobel Prize;novel;Paper;Pathway interactions;Patients;Peripheral;Phenotype;prevent;Process;Production;Publishing;receptor binding;receptor function;Recombinants;Role;Signal Induction;Signal Pathway;Signal Transduction;Site;Specificity;Structure;Structure of beta Cell of islet;Surface;T-Cell Proliferation;T-Lymphocyte;Testing;Text;Therapeutic;Tissues;TLR4 gene;Training;Translating;translation to humans;translational therapeutics;Translations;Work

PROJECT_TITLE: Mechanistic and Therapeutic Role of the TLR4 Signaling Pathway in T1D

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-2 (O1)]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project narrative Critical maturation steps of mammalian heart development include critical changes in cell structure, metabolism and gene expression of cardiomyocytes take place during the first few weeks after birth all of which are essential for the proper function of the heart. Recently, our lab found Growth differentiation factor 10 (GDF10), also known as Bmp3b, to be an upregulated ligand in postnatal cardiac fibroblasts compared to mature quiescent fibroblasts which suggests GDF10 to have a role in the crosstalk between cardiomyocytes and fibroblasts during neonatal development. This proposal seeks to determine if GDF10 is a key crosstalk ligand between fibroblasts and cardiomyocytes in mammalian in vivo and in vitro postnatal cardiac development and if the loss of this communication impairs maturation of cardiomyocytes by decreasing cardiomyocyte hypertrophy and mitochondrial maturation.

PI_NAMEs: USCATEGUI CALDERON, MARIA  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Activin Receptor;Adipocytes;Adult;aged;anti aging;Birth;Cardiac;Cardiac Myocytes;cardiogenesis;Cell Size;cell type;Cells;Cellular Structures;Communication;Communication impairment;comparison control;confocal imaging;Contractile Proteins;Contracts;Data;Defect;Development;Dominant-Negative Mutation;Electron Microscopy;Exhibits;Family;fetal;Fibroblasts;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;glucose metabolism;Goals;Growth;growth differentiation factor 10;Heart;heart function;High Fat Diet;Hypertrophy;Hypoplastic Left Heart Syndrome;In Situ Hybridization;In Vitro;in vivo;inhibitor;Injury;Knockout Mice;Laboratory Finding;Left ventricular structure;Ligands;Link;lipid metabolism;Liver diseases;Maintenance;Measures;Mediating;Membrane Potentials;Mesenchymal Stem Cells;Metabolic;Metabolism;microscopic imaging;Mitochondria;Mus;Muscle;Muscle Cells;Muscle Proteins;Myocardial;Myosin ATPase;Neonatal;neonatal mice;Nuclear;Pathway interactions;Phosphorylation;postnatal;postnatal period;PPAR gamma;Prevention;Proliferating;Protein Isoforms;Rattus;receptor;receptor expression;Recombinants;Relaxation;response;RNA;Role;Signal Induction;Signal Transduction;single cell sequencing;Skeletal Muscle;small hairpin RNA;Small Interfering RNA;Structure;Testing;Time;transcriptome sequencing;Ventricular

PROJECT_TITLE: GDF10 in Neonatal Heart Development


ORG_CITY: WILMETTE

ORG_NAME: APLEXIS, INC.

PHR: PROJECT NARRATIVE Thrombosis is a common complication and one of the leading causes of mortality and morbidity in patients with myeloproliferative disorders. Our proposed study focuses on the development of small molecule inhibitors of a novel drug target named Plek2 to treat thrombosis in these disorders, which will lay the foundation for future clinical trials of new therapeutic strategies.

PI_NAMEs: YANG, JING  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Acute;Agreement;Anemia;Arteries;Aspirin;Binding;Binding Proteins;Biological Assay;Biometry;Blood Cell Count;Bone Marrow;Cells;Chronic;Chronic Phase;clinical candidate;Clinical Management;Clinical Trials;Collaborations;Complication;Data;Development;Disease;Drug Kinetics;Drug Targeting;effective therapy;efficacy testing;Ensure;Face;FDA approved;Formulation;Foundations;Future;Generations;Genetic study;Goals;Grant;Hematopoiesis;Hematopoietic;Hemorrhage;Hemorrhagic Thrombocythemia;Hepatocyte;high throughput screening;Human;hydroxyurea;Impairment;in silico;In Vitro;in vivo;infancy;Inhibition of Cell Proliferation;inhibitor;innovation;Intellectual Property;Interferons;Investigation;JAK2 gene;Knock-in Mouse;Knock-out;Knockout Mice;Laboratories;Lead;Legal patent;Licensing;Membrane;Modeling;molecular targeted therapies;Morbidity - disease rate;mortality;mouse genetics;mouse model;Mus;mutant;Mutation;Myeloproliferative disease;Names;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Organoids;overexpression;Pathogenesis;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Chemistry;Phase;phase 1 study;Phenotype;Phosphatidylinositols;PIK3CG gene;platelet protein P47;Polycythemia Vera;Positioning Attribute;pre-clinical;preclinical study;Primary Myelofibrosis;Production;Proteins;Publishing;Quality of life;recruit;Research;Rest;Risk;Role;Safety;Scaffolding Protein;scale up;side effect;Signal Transduction;Site;Small Business Innovation Research Grant;small molecule;small molecule inhibitor;Spleen;Stat5 protein;success;Technology;Testing;Therapeutic Effect;Thrombocytopenia;Thrombosis;Toxic effect;Universities;Veins

PROJECT_TITLE: Developing small molecule inhibitors of Pleckstrin-2 to treat thrombosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (10)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cocaine;Drug Abuse (NIDA only);Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: IOWA CITY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Relapse to cocaine use remains a pervasive and difficult-to-treat problem for addressing cocaine use disorder. In particular, the specific neural pathways and network activity underlying the extinction and inhibition of cocaine seeking remain unclear. By elucidating the circuits and network function underlying relapse-like behaviors, this proposal will provide fundamental knowledge regarding cocaine use disorder and lay the groundwork for future studies that can use such knowledge to develop better treatments to prevent relapse.

PI_NAMEs: ZIMBELMAN, ALEXA RYAN (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: Address;Amygdaloid structure;barrier to care;Behavior;Behavior Disorders;Behavioral;Behavioral Paradigm;Brain;Brain region;career;Cocaine;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;Complex;conditioned fear;Cues;Development;drug craving;drug seeking behavior;Educational process of instructing;Electrophysiology (science);Environment;Etiology;experimental study;Extinction;Failure;Female;Fright;Future;Goals;Impairment;insight;Iowa;Knowledge;Laboratories;Learning;learning extinction;Lighting;male;Mediating;Mentors;Mood Disorders;neural;neural circuit;neural network;Neural Pathways;Neurons;Neurosciences;Neurosciences Research;novel;optogenetics;Pathway interactions;Pharmaceutical Preparations;Play;Procedures;programs;Prosencephalon;psychologic;Rattus;Relapse;relapse prevention;Reporting;Research;Research Personnel;Resources;Rodent;Role;Science;Site;skills;symposium;System;Techniques;Theta Rhythm;Training;Universities;Work;Writing

PROJECT_TITLE: Competing basolateral amygdala inputs to the infralimbic and prelimbic cortices in cocaine-seeking behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ORG_CITY: BRIDGEWATER

ORG_NAME: NANOSEPEX INC.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Our project focuses on the recovery of solvents from low-concentration waste streams that typically come from Superfund sites. These waste streams contain various solvents such as chlorinated and aromatic solvents, DNAPL, MTBE, tetrahydro furan, and others. Our proposed technology, Microwave Induced Membrane Distillation with Carbon Nanotube Immobilized Membrane or MIMD-CNIM, aims to concentrate the solvent form the waste streams, which then can be used to generate pure solvents for resale or used for other applications.

PI_NAMEs: LI, CHENG  (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TITLE: Development of Microwave Induced Membrane Distillation with Carbon Nanotube Immobilized Membranes: A Sustainable Solution for Solvent Recovery from Aqueous Wastes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (12)]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Nanotechnology;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT RELEVANCE The proposed project will continue the development of prostate cancer cell-targeted ultrasound contrast agents, called nanobubbles, which will be used to guide prostate biopsies under transrectal ultrasound (TRUS) imaging. Successfully developed nanobubbles will depict the pattern of primary tumor within or outside the prostate gland and inform planning for biopsy and surgical approaches. In turn, improved biopsies will lead to increased detection of high grade tumors and tumor staging, and lower morbidity.

PI_NAMEs: BASILION, JAMES PETER;EXNER, AGATA A (contact);KOLIOS, MICHAEL

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Acoustics;Advanced Development;Algorithms;Animal Model;Award;Benchmarking;Binding;Biodistribution;Biological Markers;Biopsy;Blood capillaries;Blood Vessels;cancer cell;cancer diagnosis;cancer imaging;canine model;Canis familiaris;Caring;Cause of Death;Cells;Clinical;clinical translation;Clinical Trials;Collaborations;commercialization;Complement;contrast enhanced;contrast imaging;Contrast Media;Core Biopsy;cost;Data;density;Detection;detection sensitivity;Development;Diagnosis;Diagnostic Neoplasm Staging;Diameter;Engineering;Equipment;Extravasation;FDA approved;feasibility research;FOLH1 gene;Formulation;Frequencies;Funding;Future;Gases;Hour;Image;image processing;imaging approach;imaging biomarker;Imaging Techniques;improved;In Vitro;Industry;Interdisciplinary Study;interest;Lesion;Malignant neoplasm of prostate;Malignant Neoplasms;Methods;Microbubbles;Modeling;Morbidity - disease rate;mortality;nanobubble;nanoparticle;Needle biopsy procedure;Noise;Operative Surgical Procedures;Outcome;overexpression;Pattern;Phase;Physiologic pulse;pre-clinical;Preparation;pressure;Primary Neoplasm;Procedures;Process;Production;Property;Prostate;prostate biopsy;prostate cancer cell;prostate cancer model;Protocols documentation;Rattus;Reproducibility;Research;Resolution;response;Risk;Safety;Sampling;scale up;Screening for Prostate Cancer;Sensitivity and Specificity;Signal Transduction;soft tissue;standard of care;Structure;targeted agent;Techniques;Technology;Testing;Time;time use;Tissues;tool;Toxicology;Translating;Translations;transmission process;Transrectal Ultrasound;tumor;tumor specificity;Ultrasonic Transducer;Ultrasonography;ultrasound;uptake;Urology;viscoelasticity;Visualization;Work

PROJECT_TITLE: Improved Detection of Prostate Cancer with Nanoparticle-based Ultrasound Contrast Agents Targeted to PSMA

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE Cardiovascular disease remains the number one cause of death in the United States. Emerging data indicate important roles for non-coding RNAs in the regulation of inflammation and atherosclerosis, yet this is an understudied area. Our work aims to fill this void by investigating how long noncoding RNAs contribute to cardiovascular disease, with the ultimate goal of identifying novel diagnostic approaches and therapeutic targets for its treatment.

PI_NAMEs: MOORE, KATHRYN J (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: 3-Dimensional;Affect;Animal Model;Antisense Oligonucleotides;Area;Arterial Fatty Streak;Arthritis;Atherosclerosis;Bioinformatics;Blood;Blood Vessels;Cardiovascular Diseases;cardiovascular health;Carotid Artery Plaques;Cathepsin C;Cause of Death;Cell Nucleus;Cell Physiology;Cells;Cholesterol;Chromatin;Clinical;Clinical Data;Code;cohort;Coronary artery;CRISPR/Cas technology;Cytoplasm;Data;design;diagnostic strategy;Disease;Distal;DNA;drug development;Ectopic Expression;Epigenetic Process;Event;extracellular;gain of function;Gene Expression;Genes;Genetic Transcription;Genome;Goals;Growth;Health;Human;Human Genome;human model;human tissue;Immune;Immune response;in silico;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;innovation;Interleukin-1 beta;Investigation;Knowledge;Ligands;Link;loss of function;Lung Diseases;Macrophage;Malignant Neoplasms;MAP Kinase Gene;Mass Spectrum Analysis;Messenger RNA;Modeling;Molecular;molecular phenotype;mortality;mouse model;Mus;Mutagenesis;Myeloid Cells;Myocardial Infarction;Names;Necrosis;neuroinflammation;neutrophil;NF-kappa B;novel;novel diagnostics;novel therapeutic intervention;Pathway interactions;Patients;Peptide Hydrolases;Phenotype;Play;Population;posttranscriptional;Precipitation;Process;protease C;Proteins;Regulation;Research;research and development;response;RNA;RNA Splicing;Role;Rupture;Sampling;Signal Transduction;Stenosis;Sterility;Stimulus;Stroke;sudden cardiac death;Systems Biology;Terminator Regions;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Therapeutic Uses;Tissue Model;Transcript;Transcription Process;transcriptome sequencing;Translations;United States;Untranslated RNA;Work

PROJECT_TITLE: Long noncoding RNA regulation of Atherosclerotic Cardiovascular Disease

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: Loma Linda

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: LOMA LINDA UNIVERSITY

PHR: NARRATIVE Subarachnoid hemorrhage (SAH) is a severe type of stroke with high case fatality and long-term neurological deficits in surviving patients. This proposal will study the role of cerebral venous circulation in SAH by developing and characterizing a new mouse model of SAH with ipsilateral jugular venous occlusion and explore potential therapeutic strategies to alleviate increased intracranial pressure after SAH with venous occlusion. This study will provide a new perspective on contribution of venous system in SAH pathophysiology.

PI_NAMEs: ZHANG, JOHN H (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: absorption;Acute;Address;Affect;age difference;Anatomy;Aneurysm;Aneurysmal Subarachnoid Hemorrhages;Angiography;Animal Model;arachnoid villi;Arteries;Back;Blood;Blood Circulation;Blood Volume;Brain;Brain Edema;Brain hemorrhage;Brain Injuries;brain volume;Cephalic;Cerebral Angiography;cerebral blood volume;Cerebral Edema;Cerebral hemisphere hemorrhage;cerebral vein;Cerebrospinal Fluid;cerebrospinal fluid flow;Cerebrum;Circulation;Death Rate;Development;Drainage procedure;Female;Functional disorder;functional outcomes;glymphatic system;Goals;Hemorrhage;Homeostasis;Hydrocephalus;Hypertension;Hyponatremia;imaging study;Impairment;improved;Inflammation;Internal jugular vein structure;Intracranial Hypertension;Intracranial Pressure;Intracranial Sinus Thrombosis;Ipsilateral;Life;Lymphatic;Modeling;Morbidity - disease rate;Morphology;mortality;mouse model;neurobehavior;Neurologic Deficit;novel therapeutic intervention;Obstruction;Outcome;Output;Pathology;Patient-Focused Outcomes;Patients;Pattern;Perforation;Play;pre-clinical;pressure;prevent;Production;Prognosis;Refractory;Research;Resistance;Risk;Risk Factors;Role;Rupture;Ruptured Aneurysm;Secondary to;Series;Sex Differences;Sinus;Stenosis;Stroke;Structure of jugular vein;Subarachnoid Hemorrhage;Subdural Hematoma;Survivors;Therapeutic;therapy development;Thrombosis;Translating;Variant;vascular bed;Vasospasm;vein occlusion;Venous;venous sinus;Venous system;Venous Thrombosis

PROJECT_TITLE: The role of venous impairment in subarachnoid hemorrhage pathophysiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-T (02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Narrative: A community-academic team will respond to the East Palestine derailment with a health tracking survey and strategies to engage the community in identifying their communication needs and environmental health research directions.

PI_NAMEs: HAYNES, ERIN N (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Acrylates;Address;Air;Area;Back;Breathing;Chemicals;Communication;Communication Tools;Communities;community engagement;community partners;controlled release;County;Data;Data Reporting;data sharing;Disasters;dissemination strategy;Ensure;Environmental Health;Evaluation;experience;Explosion;Exposure to;Eye;Fire - disasters;Focus Groups;Frustration;Future;Hazardous Substances;Headache;Health;health data;health literacy;health science research;Home;Inhalation;insight;Institutional Review Boards;Investigation;irritation;Learning;Lifting;Measures;meetings;member;Methodological Studies;Newsletter;Odors;Ohio;Outcome;Participant;Patient Recruitments;Personal Satisfaction;Poison;Population;prevent;Process;psychosocial;Railroads;Recommendation;Reporting;repository;Research;Research Activity;research data dissemination;Research Personnel;Research Priority;research study;respiratory;response;Risk;Safety;Series;Skin;social;Soil;Specificity;Stress;Structure;Surveys;Symptoms;Time;Training;traumatic stress;Trust;United States Environmental Protection Agency;Universities;Update;Vinyl Chloride;Water;web site;Well in self

PROJECT_TITLE: R21-UKY East Palestine Train Derailment Health Tracking Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-D (TS)]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: South Portland

ORG_NAME: UNAR LABS, LLC

ORG_STATE: ME

PHR: PROJECT NARRATIVE The lack of access to educational and instructional materials is hugely detrimental to the educational attainment of blind and visually impaired (BVI) learners and it negatively affects their quality of life and socio-economic status. This STTR project proposes a novel AI system, Midlinatm, that will provide an end-to-end accessibility pipeline solution for creation of accessible STEM materials and flexibly delivering the accessible content across multiple hardware and software platforms. Successful completion of this project will lead to increased participation of BVI individuals in STEM programs, promote independence for BVI learners and will make educational institutions more inclusive and equitable.

PI_NAMEs: PALANI, HARI PRASATH  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Address;Affect;Age;Area;Artificial Intelligence;blind;braille;Cellular Phone;college;commercial application;commercialization;Computer software;Computers;Consumption;cost;Data Reporting;Development;Devices;digital media;Education;Educational Curriculum;Educational Materials;Equity;Evaluation;experience;Expert Systems;field study;flexibility;Generations;Goals;Graph;Human;human subject;Image;improved;Individual;Institution;Institutional Review Boards;Intuition;junior high school;Lead;Learning;learning materials;Manuals;Mathematics;Mathematics Curriculum;Methods;multimodality;Nature;novel;Performance;Phase;portability;prevent;Process;Production;Productivity;Professional Competence;prototype;Quality of life;Reading;Sampling;School-Age Population;Schools;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Self-Help Devices;skills;Small Business Technology Transfer Research;smartphone application;Socioeconomic Status;STEM curriculum;STEM program;Study Subject;success;System;Tablets;Tactile;teacher;Technology;technology platform;Testing;Time;Translating;United States;usability;vision science;Visual;Visual impairment;visual information;Visually Impaired Persons;Visually Impaired Students;web app;Workplace

PROJECT_TITLE: STTR Phase II - Development of a visual-to-tactile conversion system for automating the tactile graphic generation process

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-M (12)]


ORG_CITY: SAN FRANCISCO

ORG_NAME: XCELLASSAY, INC.

ORG_STATE: CA

PHR: The advantage of a multiplexed BioAssay approach is that it permits a rapid, low-cost ‘yes/no’ alert to the presence of any chemicals at concentrations in water sufficient to alter a protein’s physiologic function. The hypothesis is that most water samples will test negative and that a positive test will inform the water agency of any previously unknown or known contaminants. Such a low-cost BioAssay ‘first-pass’ survey can have far- reaching ENVORNMENTAL IMPACT as a comprehensive and affordable identifier of ‘dirty’ water to be prioritized for characterizing the responsible chemical entity and its entry routes into the water supply.

PI_NAMEs: SCHAUFELE, FRED J (contact)

PROJECT_TERMS: Address;analytical method;authority;Bar Codes;Biological;Biological Assay;California;Chemical Structure;Chemicals;Collection;contaminated water;cost;cost effective;Data;Databases;Detection;detection method;Disinfectants;drinking water;Endocrine Disruptors;Equity;Evaluation;evidence base;Frequencies;improved;in vitro Bioassay;innovation;Inorganic Chemicals;instrument;interest;International;Measurement;Measures;Methods;Molecular;Molecular Target;Monitor;Nature;novel;Nuclear;Nuclear Proteins;Nuclear Receptors;Organic Chemicals;Phase;phase 1 study;Physiological;Play;Prevalence;Price;Process;Production;Proteins;Protocols documentation;Reagent;receptor;red fluorescent protein;remediation;Reporting;Reproducibility;Resources;response;Robotics;Route;Safety;Sampling;Signal Pathway;Site;Small Business Innovation Research Grant;Source;Specificity;Surveys;System;Testing;tool;tool development;Water;water quality;water sampling;Water Supply;water testing;Xenobiotics

PROJECT_TITLE: Multiplexed Nuclear Receptor BioAssay platform to inexpensively and broadly survey the nation's water supply for contamination by endocrine disrupting chemicals


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Disability Research;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: Shoreview

ORG_NAME: ASTER LABS, INC.

ORG_STATE: MN

PHR: Project Narrative As the number of elderly individuals suffering from dementia in the U.S. continues to significantly increase, solutions are needed to assist these individuals in maintaining functional independence for as long as possible while still safe, and provide caregivers and clinicians ongoing assessment of Activities of Daily Living, in order to improve outcomes from continuous evaluation of patients’ disease progression over time. Leading clinical research on practical interventions shows strong benefits from patients’ use of compensatory memory techniques to report ADL and other healthy behaviors performed, and these interventions, along with appropriate responses and adjustments to caregiving, have helped prevent or delay dementia onset and preserve functional abilities. The proposed research addresses an important unmet need to continuously monitor, and accurately and automatically validate whether expected ADL were performed as expected, without the need for direct caregiver observation, which will provide remotely-located caregivers, physicians, and cognitive rehabilitation therapists with verified and reliable information on whether these important activities were achieved or had lapsed, and promoting informed decisions on diagnosis, interventions, and level of care.

PI_NAMEs: SHEIKH, SUNEEL ISMAIL (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Activities of Daily Living;Address;aging in place;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;American;automated assessment;Bathing;Behavior;care giving burden;care providers;Caregivers;caregiving;Caring;Charge;Clinic;Clinical;Clinical Research;cognitive rehabilitation;Collaborations;Collection;community living;Complement;Computer software;Data;Data Analyses;data handling;Dementia;dementia care;Dementia caregivers;design;detection platform;Development;Devices;Diagnosis;Disease Progression;Eating;efficacy evaluation;Elderly;Electronics;Engineering;Evaluation;experimental study;Face;Family Caregiver;fitness;Florida;Focus Groups;Frequencies;functional independence;Home;human study;Hygiene;Impaired cognition;improved outcome;Independent Living;Individual;informal caregiver;Infrastructure;innovation;insight;Intervention;Laboratories;Location;Manuals;Memory;Monitor;non-compliance;Notification;Outcome;Patient Care;patient privacy;Patients;Performance;Persons;Phase;phase 1 testing;Physicians;poor health outcome;Population;preservation;prevent;primary caregiver;Privacy;Privatization;programs;prototype;Recommendation;remote health care;Reporting;Research;Research Personnel;response;Risk;Schedule;sensor;Shoes;Small Business Innovation Research Grant;smart technologies;Sterile coverings;success;System;system architecture;Techniques;Technology;Testing;Thinking;Time;United States;Universities;Validation;Visual;wearable device;wireless fidelity;Work

PROJECT_TITLE: Automated System for Detecting and Reporting Lapses in Performance of Activities of Daily Living for Independent and Cohabitating Persons with Alzheimer's Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-J (10)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Health Services;Mental Health;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative Costs of care and concerns about affordability are among the most prominent barriers to mental health services, even among Americans with commercial health insurance. The state of New Mexico passed a law (SB 317) to eliminate cost-sharing for mental health and substance use disorder services in commercial insurance, in order to improve access to services. The proposed study will use qualitative and quantitative methods to assess how this law is affecting the delivery of mental health services from patient and provider perspectives, and how it is affecting patterns of mental health services use and quality of care.

PI_NAMEs: GOLBERSTEIN, EZRA  (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Address;Adoption;Affect;American;barrier to care;behavioral health;Blue Cross;Blue Shield;care costs;Clinical Trials;Control Groups;cost;Cost Sharing;Data;Data Set;disability;econometrics;effective therapy;General Practitioners;Health financing;Health Insurance;health service use;Health Services Accessibility;Health Services Research;implementation evaluation;Improve Access;improved;Incidence;Individual;innovation;Insurance;Insurance Carriers;insurance claims;Insurance Coverage;insurance plan;Intervention;Interview;Laws;Marketing;medical specialties;Mental disorders;Mental Health;Mental Health Services;Methods;National Institute of Mental Health;Natural experiment;New Mexico;NIH Program Announcements;Outcome;parity;Patients;Pattern;Persons;Pharmaceutical Preparations;Policies;Policy Maker;Population;Premature Mortality;Prevalence;Privatization;Provider;Quality of Care;Quasi-experiment;Research;response;Sampling;service utilization;Services;Substance Use Disorder;Suicide;Work

PROJECT_TITLE: The Effects of Zero Cost-sharing on Mental Health Service Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-G (04)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Cardiovascular;Clinical Research;Emerging Infectious Diseases;Heart Disease;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: Boxborough

ORG_NAME: HELIXBIND, INC.

PHR: PROJECT NARRATIVE Endocarditis is a life-threatening disease and a significant economic burden due to prolonged intensive treatment. Early identification of the microbial infection is crucial to improving outcomes, but current standards relying on blood cultures are slow and often yield false-negative results. This prevents the administration of evidence-based antimicrobials precisely when they are maximally beneficial. The efforts described in this Phase IIB program will build upon the success demonstrated in our Phase I and Phase II and will advance the maturity of a novel, fully automated test capable of identifying and characterizing these infections directly from patient blood in only a few hours. Success in this effort will result in a critically needed diagnostic, ready for manufacturing scale up as required for FDA trials and market launch.

PI_NAMEs: SINGER, ALON  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acceleration;Address;Affect;Antibiotic Resistance;antimicrobial;Antimicrobial Resistance;assay development;Automation;Autopsy;Award;Bacteria;Biological;Biological Assay;Blood;Blood Circulation;Breakthrough device;Caring;Clinical;Clinical Microbiology;Clinical Research;commercialization;Communicable Diseases;Coxiella burnetii;Critical Care;Death Rate;Detection;Diagnosis;Diagnostic;diagnostic strategy;Disease;Disease Progression;Early identification;Economic Burden;Endocarditis;Engineering;Ensure;evidence base;Exhibits;experience;Feedback;fungus;Grant;Heart;Hospitalization;Hospitals;Hour;Human;Impairment;improved;improved outcome;Infection;Infective endocarditis;instrument;Intervention;Leadership;Lesion;Life;manufacture;manufacturing scale-up;Marketing;member;microbial;microorganism;Molds;Monitor;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;Notification;novel;novel diagnostics;Organism;pathogen;pathogenic bacteria;pathogenic fungus;Patient Care;Patient-Focused Outcomes;Patients;Performance;Phase;prevent;programs;prospective;Quality of life;Readiness;Reagent;Resistance;Resistance development;resistance gene;Risk;Sampling;Sepsis;Septicemia;Site;Small Business Innovation Research Grant;Specific qualifier value;Specificity;Specimen;standard of care;success;Surface;Symptoms;Technology;Temperature;Testing;Time;Whole Blood

PROJECT_TITLE: Direct-from-specimen identification of pathogens common in endocarditis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-Y (13)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Complementary and Integrative Health;Depression;Mental Health;Neurosciences;Palliative Care;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Family caregivers to patients with severe acute brain injury (SABI) are at risk for chronic emotional distress, yet no tailored, efficacious interventions exist to promote their mental and physical wellbeing. The proposed study aims to lay the foundation for the development of a mind-body peer support intervention for SABI caregivers through conducting preliminary quantitative and qualitative work, and adapting existing interventions with stakeholder-engaged methods. Future work can evaluate the feasibility and efficacy of the proposed intervention, and if successful, the proposed mind- body peer support intervention has wide-reaching potential to be implemented in diverse critical care settings and improve the long-term wellbeing of SABI caregivers.

PI_NAMEs: REICHMAN, MIRA  (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: Acute;Acute Brain Injuries;Address;Admission activity;Affect;Anxiety;anxiety symptoms;Benchmarking;biopsychosocial;Buffers;career;caregiver interventions;caregiver stress;Caregivers;caregiving;Caring;Chronic;Clinical Investigator;Clinical Psychology;cognitive function;Collaborations;Communication;Competence;coping;Coping Skills;cost effective;Critical Care;Critical Illness;Data;Data Set;Dedications;depressive symptoms;Development;disorder prevention;Distress;doctoral student;Educational workshop;efficacious intervention;efficacy testing;Emotional;emotional distress;Equation;Equity;experience;Family;Family Caregiver;Family member;Feedback;Feeling;Foundations;Frustration;Future;Goals;Grief reaction;Health;Health behavior change;Health Promotion;high risk;Hospitalization;human centered design;improved;Individual;Infrastructure;innovation;insight;Intensive Care Units;Intervention;intervention mapping;Interview;Learning;Linear Regressions;loved ones;Manuals;Mental Depression;Mentors;Mentorship;Methods;mind/body;mindfulness;Modeling;Motivation;multidisciplinary;multilevel analysis;National Center for Complementary and Integrative Health;neonatal hypoxic-ischemic brain injury;Neurologic;Observational Study;Patients;peer;peer support;Perception;Personal Satisfaction;Persons;physical conditioning;Physical Function;Population;prevent;programs;prospective;Psyche structure;Qualitative Methods;Quality of life;Randomized, Controlled Trials;Recovery;Reporting;Research;Research Personnel;resilience;Resource-limited setting;Resources;Risk;Sampling;satisfaction;Self Care;Self Efficacy;skills;Social Impacts;Social isolation;Social support;Social Values;Strategic Planning;Stress;stress management;Stroke;Structure;success;Technology;theories;therapy design;therapy development;Time;Training;Traumatic Brain Injury;Universities;Washington;whole health;Work

PROJECT_TITLE: Mind-Body Peer Support for Family Caregivers to Patients with Severe Acute Brain Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (01)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: Research Triangle Park

ORG_NAME: EPICYPHER, INC.

PHR: PROJECT NARRATIVE  The enzymes that add, remove, and bind ADP-ribose (ADPr) on histones are emerging as high value drug targets, given the strong connection between this class of post-translational modifications and multiple pathologies. However, the ability to perform the robust biochemical and genomic mapping studies of histone ADPr required to bolster basic and drug development research has been undermined by a lack of defined, physiological substrates and assays. Here, EpiCypher will develop a first-in-kind molecular toolbox to advance the study of ADPr signaling for drug discovery research and inhibitor development.

PI_NAMEs: HUNT, SABRINA ROBIN (contact);SUN, ZU-WEN

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Acceleration;Acetylation;Adenosine Diphosphate Ribose;ADP ribosylation;Antibodies;assay development;Bar Codes;Binding;Biochemical;biochemical tools;Biochemistry;Biological;Biological Assay;Biology;Biotinylation;Catalogs;Cell Physiology;Cells;Chemicals;chromatin remodeling;Cleavage Under Targets and Release Using Nuclease;Clinical Trials;commercialization;Complex;Detection;Development;Disease;DNA;DNA Damage;drug development;drug discovery;Drug Targeting;Enzyme Interaction;Enzymes;Epigenetic Process;FDA approved;Feasibility Studies;Generations;genomic tools;Genomics;Goals;Histones;Hydrolase;In Vitro;in vivo;inhibitor;innovation;Knowledge;Lysine;Malignant Neoplasms;manufacture;Maps;Marketing;Methods;Methylation;Modeling;Molecular;new therapeutic target;novel;Nucleosomes;Pathology;Phase;Phosphorylation;Physiological;Post-Translational Protein Processing;Proteins;Reader;Reagent;Reproducibility;Research;research and development;Role;screening;Serine;Signal Transduction;Specificity;stability testing;stem;Technology;Texas;Therapeutic;therapeutic target;tool;Universities;Validation;Work

PROJECT_TITLE: Biochemical and genomic tools to study histone ADP ribosylation signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-J (10)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

PHR: Project Narrative Chagas disease is a parasitic infection primarily in Latin America caused by Trypanosoma cruzi. Existing drugs for Chagas disease are inadequate because of severe side effects, lengthy treatment regimens, and poor efficacy. The proposed research aims to bring forward new drug treatments that meet modern-day standards for the millions of infected people.

PI_NAMEs: BUCKNER, FREDERICK SIMMONS (contact);GELB, MICHAEL H

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Ames Assay;analog;anaphase-promoting complex;Aniline;Animals;Applications Grants;aqueous;Area;Benznidazole;benzothiazole;Biological Assay;Blood;Cells;Chagas Disease;chemical synthesis;Chemistry;chemotherapy;Chromosomes;Chronic;chronic infection;Collaborations;Communicable Diseases;cytotoxicity;diazine;Disease;Dose;drug candidate;drug discovery;Drug Kinetics;experience;experimental study;follow-up;Funding;Genes;genotoxicity;Goals;Grant;Growth;high throughput screening;improved;In Vitro;in vitro Assay;Infection;Latin America;Lead;lead optimization;lead series;Left;Letters;Mammalian Cell;Metabolic;meter;Mitosis;Mitosis Inhibition;Modeling;Modernization;mouse model;Mus;Mutagenicity Tests;Mutation;neglect;novel;novel therapeutics;Oxazoles;Parasite resistance;Parasites;Parasitic infection;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenotype;pre-clinical;preclinical development;Property;Relationship-Building;Reporting;Research;Resistance;response;Risk;Safety;scaffold;screening;Series;side effect;Solubility;Structure-Activity Relationship;Testing;Toxic effect;Toxicology;Transfection;Treatment Protocols;Trypanocidal Agents;Trypanosoma;Trypanosoma cruzi;Universities;Work

PROJECT_TITLE: Drug Discovery for Chagas Disease

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


ORG_CITY: ALBUQUERQUE

ORG_NAME: SHEARIT, LLC

ORG_STATE: NM

PHR: Project Narrative Two FDA approved treatments for large vessel occlusion acute ischemic stroke (AIS) to dissolve the clot by recombinant tissue plasminogen activator (rtPA thrombolysis) or extract the clot (endovascular arterial thrombectomy-EAT) require a ratio (1.8) of ischemic penumbra (tissue near death) /core (dead tissue) volumes plus two measures of stroke severity to qualify for intervention. Only 25% of the annual 800,000 first ever AIS in the US and 16.9M globally would qualify for treatment; Lamiflo™ uniquely enhances flow by altering the physical dynamics of blood and red blood cell (RBC) flow, not pharmacologically. By reducing the ischemic penumbra and core after onset of AIS, Lamiflo™ will increase the number of patients qualifying for tPA thrombolysis and EAT intervention and improved neurologic recovery without increasing hemorrhagic transformation.

PI_NAMEs: NEMOTO, EDWIN M (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: 1 year old;Acclimatization;Acute;Adhesions;Agreement;Alteplase;Atherosclerosis;Biological Markers;Blood;Blood capillaries;Blood Coagulation Disorders;Blood flow;Blood specimen;Blood Vessels;blood-brain barrier permeabilization;Brain;Canis familiaris;Cell Density;Cell Wall;Cerebrovascular Circulation;Cerebrovascular Disorders;Cessation of life;chemokine;Clinical;Clinical Trials;Coagulation Process;Collateral Circulation;comparison control;cytokine;Diameter;Diffusion;Dose;effective therapy;Embolism;Endothelium;endovascular thrombectomy;Erythrocytes;Evolution;Failure;FDA approved;Female;Filament;forest;Freezing;Friction;Gelatinase B;glial activation;Glycocalyx;Guidelines;Half-Life;Hemorrhage;Hemorrhagic Shock;Homeostasis;Human;hypercholesterolemia;Image;improved;Infarction;Inflammation;Infusion procedures;innovation;Intervention;Investigational Drugs;Iron;Ischemic Penumbra;Ischemic Stroke;Legal patent;Letters;Leukocytes;Liquid substance;lung hypoxia;Magnetic Resonance Imaging;male;Malignant Neoplasms;Maps;Marketing;Measures;Medical;middle age;Middle Cerebral Artery Occlusion;Modification;Molecular Weight;Musculoskeletal;Myocardial Ischemia;Neoplasm Metastasis;neurobehavioral;neurobehavioral test;Neurological outcome;neurological recovery;neuroprotection;Neuroprotective Agents;Neurosciences;Nitric Oxide;Oryctolagus cuniculus;participant enrollment;Patient imaging;Patients;Performance;Perfusion;Permeability;pharmacologic;Phase;phase 1 study;Plasma;Play;Polyethylene Glycols;Polymers;post stroke;Predisposition;Property;psychosocial;pulmonary arterial hypertension;Qualifying;quantitative imaging;Rain;Rattus;Recovery;Reperfusion Therapy;Reporting;restoration;revascularization;Role;Severities;Shunt Device;Small Business Innovation Research Grant;Sprague-Dawley Rats;Stains;Stroke;Stroke prevention;Surface;Technology;Thrombectomy;thrombolysis;Thrombus;tissue oxygenation;Tissue Viability;Tissues;Translating;Traumatic Brain Injury;Vascular calcification;Vasodilator Agents;Water;Width;Withdrawal

PROJECT_TITLE: Extending the Ischemic Penumbra in Large Vessel Occlusion Stroke

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-S (14)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Diabetes;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: Belchertown

ORG_NAME: REGENE LLC

PHR: This project is focusing on the development of novel drug therapy for the prevention and treatment of Alzheimer’s Disease (AD) and AD-related dementias. The new therapy will target brain insulin resistance – a putative mechanism of AD known as Type 3 Diabetes. In the course of the project, new drugs will be optimized and tested for therapeutic effects associated with AD and AD-related dementias.

PI_NAMEs: EYERMANN, CHARLES JOSEPH;SUVOROV, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: 3xTg-AD mouse;absorption;Affect;Affinity;Age Months;age related decline;age related neurodegeneration;aged;Aging;aging related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease therapy;Amyloid beta-Protein;Anti-diabetic Drugs;Autophagocytosis;Brain;Characteristics;chemical property;Chronic;Clinical;cognitive benefits;cognitive function;Complex;Computer Models;Development;Diabetes Mellitus;diabetes pathogenesis;Disease;Disease Progression;drug candidate;drug development;Drug Kinetics;Elderly;Event;Excretory function;experimental study;extend lifespan;Feedback;frailty;FRAP1 gene;glucose metabolism;Goals;growth hormone deficiency;Growth Hormone Receptor;Hand Strength;HepG2;Hormonal;hormonal signals;Human;IGF1 gene;Impaired cognition;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Insulin;Insulin Receptor;insulin receptor substrate 1 protein;Insulin Resistance;insulin signaling;Insulin Signaling Pathway;Insulin-Like-Growth Factor I Receptor;Intervention;Knockout Mice;Link;long term memory;Longevity;Maintenance;Mediating;MEKs;Metabolism;Metformin;misfolded protein;model organism;Modeling;Molecular;Motor;mouse model;Mus;Nerve Degeneration;neuroinflammation;NF-kappa B;novel;novel therapeutics;old mice;Oral Administration;Pathologic;Pathology;Pathway interactions;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;preclinical development;prevent;Prevention;Prevention therapy;Property;prophylactic;receptor;Receptor Inhibition;Research;Short-Term Memory;Signal Transduction;small molecule;small molecule inhibitor;Somatomedins;Somatotropin;success;tau Proteins;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Toxic effect;Wild Type Mouse

PROJECT_TITLE: Targeting Type 3 Diabetes (T3D) Mechanism of Alzheimer's Disease (AD) and AD-Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-P (11)]