ORG_CITY: EMMITSBURG

ORG_NAME: MOUNT ST. MARY'S UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The health of our cells requires that the enzymes we rely on to perform chemical reactions carry out their functions at the appropriate locations and times. The goal of this project is to understand how the protein ASCC2 directs certain enzymes to the locations where they are needed. This research will improve our understanding of the processes that rely on ASCC2 to function properly, such as DNA damage repair.

PI_NAMEs: LOMBARDI, PATRICK  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Administrative Supplement;Affinity;Agreement;Alkylating Agents;Alkylation;Area;beamline;Binding;Binding Sites;Biochemistry;Biological;Biological Assay;Biological Process;Cell Physiology;Cell Survival;Cells;chemical reaction;Chemicals;Collaborations;Complex;Data;Defect;disease diagnosis;DNA Alkylation;DNA Repair;Docking;Enzymes;experimental study;Funding;Genetic Diseases;Genetic Transcription;Goals;Health;Home;Immunofluorescence Microscopy;improved;In Vitro;instrumentation;intermolecular interaction;Knock-out;Label;Laboratories;Link;Location;Maps;Mediating;member;Modeling;Multiprotein Complexes;Mutagenesis;mutant;Mutate;Mutation;NMR Spectroscopy;Nuclear;Nuclear Magnetic Resonance;Pathway interactions;Polyubiquitin;preference;Principal Investigator;Process;protein complex;Proteins;recruit;Relaxation;Repair Complex;repaired;Research;Research Personnel;response;restraint;Ribosomes;Roentgen Rays;Scientist;Shapes;Signal Transduction;Site;Specificity;Structure;Students;Travel;Ubiquitin;undergraduate student;Universities;university student;Washington;Work

PROJECT_TITLE: Administrative supplement to investigate the localization of DNA alkylation damage repair complexes via ubiquitin signaling


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative CRISPR-Cas9 systems are frequently found in pathogenic bacteria, where they defend against phages but also prevent the horizontal transfer of antibiotic resistance genes and toxins. Here, we explore novel functions of Cas9 as a non-canonical transcriptional regulator, which could contribute to bacterial pathophysiology and inform new generations of regulatable Cas9 tools for the treatment of genetic diseases. We also study the heterogeneity of CRISPR-Cas immunity in single cells, which will have implications for the survival of human pathogens under stress and their treatment with phage therapies.

PI_NAMEs: MODELL, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: adaptive immunity;Antibiotic Resistance;Autoimmunity;Bacteria;Bacterial Chromosomes;Bacterial Genes;Bacteriophages;Biology;Cells;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;commensal bacteria;CRISPR/Cas technology;Development;drug resistant pathogen;Environment;Equilibrium;Event;Foundations;Functional disorder;gene editing technology;Generations;Genetic;Genetic Diseases;genetic element;Genetic Transcription;Guide RNA;Heterogeneity;Horizontal Gene Transfer;human pathogen;imaging platform;Immunity;Immunization;Infection;innovation;insight;Laboratory Study;Memory;novel;nuclease;pathogenic bacteria;Physiology;Plasmids;Population;prevent;promoter;Regulation;Repression;Research Design;resistance gene;Role;Route;spatiotemporal;Streptococcus pyogenes;Stress;System;Technology;Time;tool;Toxin;Transcription Repressor

PROJECT_TITLE: Non-canonical functions of Cas9 andthe cell biology of CRISPR-Cas immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Disability Research;Hearing Loss;Neurodegenerative;Neurosciences

ORG_CITY: TAMPA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: The number one neurodegenerative and sensory disorder of the elderly is age-related hearing loss (ARHL), where there are no FDA-approved medical treatments, since its biological mechanisms remain elusive, and analytical techniques needed to clinically diagnose auditory pathologies are still lacking. One such auditory pathology relates to the noticeable decline of a critical part of the inner ear: the “cochlear battery”, commonly known as the endocochlear potential, and is considered as a predominant mechanism of ARHL and other types of hearing loss. The thematic focus of this proposal is to develop an innovative and non-invasive method to measure the “cochlear battery” clinically, to serve as guidance into future targeted therapeutic interventions, both technological and medicinal in nature.

PI_NAMEs: FRISINA, ROBERT D (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Active Biological Transport;Age;Age Months;age related;age related changes;Aging;aging population;analog;Animal Model;Animals;Atrophic;Auditory;Autopsy;BALB/cJ Mouse;Binding;Biological;Biological Markers;Biological Process;Biomedical Engineering;biomedical imaging;Blood flow;blood perfusion;Bone neoplasms;Brain;Bulla;Bumetanide;Cadaver;CBA/CaJ Mouse;Cell Death;Cells;Characteristics;Clinical;clinical diagnosis;clinical risk;clinically relevant;Cochlea;Cochlear duct;Complication;detection method;Development;Diagnosis;Diagnostic;Diffuse;Diffusion;Discipline of Nuclear Medicine;dosage;Dose;Elderly;Endolymph;enzyme activity;Etiology;Event;Exhibits;experimental study;FDA approved;feasibility testing;Future;Gamma Cameras;Gamma Rays;Gene Expression;Generations;Half-Life;Hearing;hearing impairment;Heart;heart visualization;Hepatobiliary;Hot Spot;Human;human subject;Image;imaging modality;imaging system;Imaging Techniques;in vivo;Injections;innovation;Intervention;Ion Channel;Ions;Label;Labyrinth;Lateral;Liquid substance;longitudinal animal study;longitudinal human study;magnetic field;Maintenance;Mammals;Measurement;Measures;Medical;Medicine;Methodology;Methods;Microelectrodes;Miraluma;Molecular;molecular imaging;Movement;Mus;Na(+)-K(+)-Exchanging ATPase;Nature;Neoplasm Metastasis;Nerve Degeneration;Neurodegenerative Disorders;normal hearing;novel;nuclear imaging;Operative Surgical Procedures;Organ;Ouabain;Pathogenesis;Pathology;Patients;permanent hearing loss;Persons;Pharmaceutical Preparations;Photons;Physiological;Positron-Emission Tomography;Presbycusis;prevent;Procedures;Protocols documentation;Radial;Radiation;Radioactive;Radioactive Tracers;Radionuclide Imaging;Radiopharmaceuticals;radiotracer;Reporting;Research;Resolution;Risk Factors;Rodent;Roentgen Rays;Scanning;Science;screening;Sensorineural Hearing Loss;Sensory Disorders;Signal Transduction;single photon emission computed tomography;Source;Stria Vascularis;Study models;symporter;targeted treatment;Techniques;Technology;temporal measurement;Testing;Thallium;Therapeutic Intervention;Thyroid Gland;Time;Tissues;Tracer;tumor;two-dimensional;Validation;voltage;wireless;X-Ray Computed Tomography;young adult

PROJECT_TITLE: Novel Biomedical Imaging Systems for Diagnosing Hearing Loss


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Hearing Loss;Neurosciences;Pediatric;Prevention;Rehabilitation

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE The proposed project maps out the developmental trajectories of spatial hearing abilities in complex reverberant environments for school-age children with normal hearing. Findings of this work will provide intervention benchmarks to guide the fitting of bilateral hearing devices (e.g., cochlear implants and hearing aids) for children with hearing loss.

PI_NAMEs: PENG, ZHAO ELLEN (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: 12 year old;18 year old;5 year old;9 year old;Address;Adult;Affect;Age;Area;Auditory;Auditory Perception;auditory processing;Benchmarking;Bilateral;Binaural;Child;Cochlear Implants;Communication;Complex;Cueing for speech;Cues;Data;Development;Devices;educational atmosphere;Environment;Foundations;Goals;Hearing;Hearing Aids;hearing impairment;Hearing Tests;Image;Impairment;improved;innovation;Intervention;Knowledge;Learning;Life;Maps;Measures;National Institute on Deafness and Other Communication Disorders;noise perception;normal hearing;novel;object perception;Outcome;Outcome Measure;Pattern;Perception;Performance;precedence effect;prevent;Process;Psychophysics;Role;school environment;School-Age Population;Severities;Signal Transduction;Size Perception;skills;Social Interaction;sound;Source;Speech;speech in noise;Speech Perception;Surface;Testing;Time;virtual;virtual reality;Width;Work

PROJECT_TITLE: DEVELOPMENT OF FUNCTIONAL SPATIAL HEARING IN REVERBERATION

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: AI

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Immunotherapy;Infectious Diseases;Liver Disease;Vaccine Related

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: The role of functionally distinct hepatic T cell subsets in providing protective immunity from hepatotropic viruses, such as hepatitis C virus (HCV), or mediating liver pathology during inflammatory liver disease is poorly defined. Using a mouse model of an HCV-related virus we will investigate the functional properties and potential interplay of distinct type 1 and type 2 T cell and natural killer T (NKT) cell subsets during different stages of hepacivirus infection in vivo. Our results should reveal new concepts of hepatic T cell immunity with implications for the development of HCV vaccine strategies and new therapeutic options for liver disease.

PI_NAMEs: BILLERBECK, EVA  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute;acute infection;Address;Adoptive Cell Transfers;Animal Model;Biological;Biology;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Chronic;Chronic Hepatitis C;chronic infection;chronic liver inflammation;Cirrhosis;comparison control;cytokine;Cytotoxic T-Lymphocytes;Data;Development;Disease Progression;end stage liver disease;Epitopes;Equilibrium;experimental study;Fibrosis;Flow Cytometry;Generations;Hepatic;Hepatitis B Virus;Hepatitis C;Hepatitis C Vaccination;Hepatitis C Vaccine;Hepatitis C virus;Hepatitis C-Like Viruses;Hepatocyte;high dimensionality;Human;Immune;Immune response;Immunity;Immunocompetent;Immunologics;Immunology;immunoregulation;Immunotherapeutic agent;in vivo;Infection;Inflammation;Inflammatory;innovation;insight;Interleukin-13;Interleukin-4;Kinetics;Knockout Mice;Link;Liver;Liver diseases;Liver Fibrosis;liver injury;Lymphocyte Subset;Mediating;Mediator;Memory;Metabolic stress;MHC Class I Genes;Modeling;mouse model;Mouse Strains;Mus;novel;novel therapeutics;Pathology;Patients;Phenotype;Play;polarized cell;Predisposition;Primary carcinoma of the liver cells;Property;Rattus norvegicus;repaired;response;restraint;Rodent;Role;Sampling;secondary infection;single-cell RNA sequencing;Steatohepatitis;T cell response;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Time;tissue repair;Tissues;Toxin;transcriptome;Translating;vaccination strategy;vaccine strategy;Viral;Viral hepatitis;Virus;Virus Diseases

PROJECT_TITLE: New insights into the functional diversity of the hepatic antiviral T cell response during hepacivirus infection in vivo

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE COUNTY

PHR: PROJECT NARRATIVE The loss of proteostasis during aging and upon stress leads to the accumulation of excess, damaged, and aggregated proteins which interfere with essential cellular functions and promote the onset of age-related diseases, particularly in neurons and muscle. This proposal will define the biochemical and physiological functions of an orphan lysine methyltransferase which is required for proteostasis, likely its via methyltransferase activity on molecular chaperones and other factors within the proteostasis network. These studies will broaden our understanding of the cellular mechanisms used to prevent deterioration of proteome integrity linked to diseases associated with stress and aging.

PI_NAMEs: GREEN, ERIN  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Address;Age of Onset;age-related disease;Aging;aging related;aging related disease;Biochemical;biological adaptation to stress;Biological Assay;cell age;Cell Aging;Cell Physiology;Cells;Deterioration;Disease;Enzymes;Etiology;Family;Genetic;genetic approach;Goals;insight;Link;Lysine;Methylation;Methyltransferase;Modification;Molecular;Molecular Chaperones;Muscle;Neurons;Orphan;Pathology;Physiological;Post-Translational Protein Processing;prevent;protein aggregation;Protein Biosynthesis;protein protein interaction;Proteins;Proteome;Proteomics;proteostasis;proteostasis loss;Quality Control;Role;Series;Stress;Structure;targeted treatment;Testing;Work;Yeasts

PROJECT_TITLE: Function of SMYD lysine methyltransferases in stress responses and proteostasis


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Pediatric

ORG_CITY: BETHESDA

ORG_NAME: AMERICAN GASTROENTEROLOGICAL ASSN/INST

PHR: PROJECT NARRATIVE The Best of FORWARD Program will translate aspects of the American Gastroenterological Association’s FORWARD Program for a broader audience through a multi-faceted approach to mentorship and peer networking that will enhance the career development of underrepresented physician-scientists and equip them with the skills needed to be successful in the biomedical workforce. Our long-term goal is to enhance the diversity of the biomedical science research workforce studying digestive health and prepare individuals to assume leadership positions within our professional association and in academic medicine. The Best of FORWARD Program will provide greater access to mentoring, bolster research and leadership skills, and address diversity, equity, inclusion, and access by conducting skill-building in an intensive immersion experience while maintaining sustainable relationships with mentors and accessing education via mobile-app technology that allows for flexible and accessible mentor-mentee engagement.

PI_NAMEs: CRYER, BYRON  (contact);QUEZADA, SANDRA

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Address;American;Appointment;career;career development;cohort;Communities;community building;Community Physician;design;Development;digital;digital platform;early experience;education access;Educational Curriculum;Enrollment;equity, diversity, and inclusion;Ethnic Origin;experience;Faculty;Feedback;flexibility;foster parent;Fostering;Funding;Gastroenterologist;Gastroenterology;Goals;Grant;Health;Immersion;improved;Individual;innovation;interest;Investigation;Leadership;leadership development;Measures;Medicine;mentoring community;Mentors;Mentorship;mobile application;National Institute of Diabetes and Digestive and Kidney Diseases;online community;Outcome;parent grant;parenting intervention;Participant;peer;peer coaching;peer networks;Persons;Physicians;Positioning Attribute;Principal Investigator;Professional Organizations;programs;Publications;Publishing;Race;recruit;Relationship-Building;Research;response;Role;Science;Scientist;skills;skills training;Students;success;Technology;Training;Training Programs;Translating;Underrepresented Populations

PROJECT_TITLE: Best of AGA FORWARD - Fostering Opportunities Resulting in Workforce and Research Diversity


ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative These studies leverage mammalian cell genetics to make fundamental contributions to the fields of membrane biology, intracellular lipid transport, LDL receptor function/endocytosis, the SREBP pathway, and regulation of lipid synthesis. Given that modulation of cholesterol synthesis and LDL receptor function are primary interventions in the treatment of hypercholesterolemia, these studies may identify new therapeutic targets for the prevention of heart disease.

PI_NAMEs: ESPENSHADE, PETER J. (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Address;Adult;Cell membrane;Cell Physiology;Cells;Cellular biology;Cholesterol;CRISPR/Cas technology;Endocytosis;Fatty Acids;fluidity;forward genetics;Genes;Genetic;heart disease prevention;Homeostasis;Human;hypercholesterolemia;Integral Membrane Protein;Intervention;Learning;lipid transport;Lipids;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Mammalian Cell;Membrane;Membrane Biology;Membrane Lipids;model organism;new therapeutic target;Pathway interactions;Permeability;Proteome;receptor function;Regulation;Research;United States

PROJECT_TITLE: Regulation of Membrane Lipid Homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(01)-Q]


ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health

ORG_CITY: MISSOULA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: Project Narrative The Center for Population Health Research (CPHR) is requesting NIGMS support for a mobile clinical laboratory. This equipment will support needs identified by early career CPHR investigators, including field- based community outreach, capture of clinical and environmental measures, patient/participant clinical consultations, collection of biomonitoring data, secure and private administration of survey instruments, and facilitation of qualitative data collection.

PI_NAMEs: NOONAN, CURTIS WILLIAM (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Administrative Supplement;Biological Monitoring;career;Centers for Population Health;Centers of Research Excellence;Charge;Clinical;Clinical Research;Collection;community engagement;Community Outreach;Consultations;Country;Data;Data Collection;design;disorder risk;Early identification;Ensure;Environment;Equipment;equipment acquisition;Fostering;Funding;Future;Health;High Performance Computing;improved;Intervention;Investigator-Initiated Research;Laboratories;Measures;Mentors;Mentorship;Mission;Modeling;Montana;National Institute of General Medical Sciences;operation;Outcome;Participant;Patients;Phase;population health;post-pandemic;Privatization;Qualitative Methods;recruit;Research;Research Personnel;Research Project Grants;Research Support;Rural;Rural Community;rural patients;Rural Population;rural setting;Secure;Services;Structure;Surveys;Testing

PROJECT_TITLE: Center for Population Health Research


NIH_SPENDING_CATS: Genetics

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Protein-coding genes must generate functional RNAs at the appropriate levels, and this process is controlled by many different molecular machines, including the Integrator complex and the spliceosome. The proposed studies will characterize in detail how Integrator controls the amount of RNA that is produced as well as why abundant circular RNAs are generated from many protein-coding genes by the spliceosome. This will allow us to better understand how gene outputs are controlled, thereby providing important new insights into how gene misregulation can lead to disease.

PI_NAMEs: WILUSZ, JEREMY E (contact)

PROJECT_TERMS: Attenuated;Binding;Biochemical;Biogenesis;Cell Physiology;circular RNA;Code;Complex;Coupled;crosslink;Data;Disease;Endoribonucleases;gene function;Genes;Genome;genomic locus;high throughput screening;innovation;insight;Laboratories;Length;Link;Mass Spectrum Analysis;Messenger RNA;Modality;Molecular;Molecular Machines;novel;Output;paralogous gene;Pathway interactions;Physiological;Poly(A) Tail;posttranscriptional;premature;Process;Production;Proteins;recruit;RNA;RNA Polymerase II;RNA Processing;Role;Small Nuclear RNA;Spliceosomes;Tertiary Protein Structure;Therapeutic;Transcript;transcription termination;Untranslated RNA;Work

PROJECT_TITLE: Regulatory roles for the Integrator complex and circular RNAs


NIH_SPENDING_CATS: Aging;Aphasia;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation;Stroke

ORG_CITY: MILWAUKEE

ORG_DEPT: NEUROLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Clinical applications of transcranial alternating current stimulation (tACS), a promising neuromodulation technique, aimed at improving language outcomes in stroke survivors with aphasia are limited due to the complexity in selecting stimulation parameters. Our project proposes to evaluate a multimodal approach to optimize selection of tACS parameters in individual patients. This approach will facilitate future use of tACS as an adjunctive treatment to boost therapeutic outcomes.

PI_NAMEs: SHAH-BASAK, PRIYANKA  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Anatomy;Aphasia;Articulation Disorders;Behavioral;Brain;Brain Injuries;Brain region;Cephalic;Characteristics;Chronic;clinical application;Clinical Trials;clinically relevant;Cognitive;cognitive performance;Communication;Comprehension;Contralateral;Data;design;Disease;Distant;Effectiveness;electric field;Electrodes;Electrophysiology (science);Exploratory/Developmental Grant;Foundations;Frequencies;Functional Magnetic Resonance Imaging;functional outcomes;Future;Goals;Heterogeneity;High Prevalence;Homologous Gene;Human;Impairment;improved;Individual;individual patient;individual variation;Inferior;innovation;Intervention;Ipsilateral;Knowledge;Language;language outcome;Left;Lesion;Linguistics;Link;Literature;Location;Magnetoencephalography;Maps;Mental disorders;Methodology;Modeling;multimodality;National Institute on Deafness and Other Communication Disorders;Nervous System Disorder;neural;neurological rehabilitation;neuroregulation;noninvasive brain stimulation;novel;Outcome;Participant;Performance;Phase;phonology;Physiological;Pilot Projects;post stroke;Production;Publications;Randomized;Residual state;response;Scalp structure;Services;Short-Term Memory;Signal Transduction;Site;sound;Speech;Stroke;stroke-induced aphasia;Survivors;Techniques;Testing;therapy outcome;tool;Treatment Protocols;Variant;verbal

PROJECT_TITLE: Synchronizing Oscillatory Brain Activity to Treat Post-Stroke Aphasia

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: Newark

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative The goal of this adminstrative supplement will be to support the purchase of a preparative HPLC instrument to support the research on the parent R01. The goal of the parent award is developing a diverse set of new chemical tools centered on tetrazine ligation– the fastest known bioorthogonal reaction. The work will advance new biotechnological, biomedical and pharmaceutical applications through new chemical tools for labeling biomolecules in the intracellular environment, new methods for selectively tagging and assembling proteins, and new technology for probing biological targets in living systems with spatiotemporal control.

PI_NAMEs: FOX, JOSEPH M (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Discovery of Molecular Probes and Therapeutic Leads, Equip Supp


NIH_SPENDING_CATS: Bioengineering;Infectious Diseases

PHR: Project Narrative This center of Biomedical Research Excellence is a multidisciplinary center that using synthesis, chemical biology and computation to develop molecular approaches for understanding and treating human disease, with a focus on infectious diseases and cancer.

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Administrative Supplement;Biological;Biology;Centers of Research Excellence;Chemicals;Chromatography;Communicable Diseases;Communities;Custom;Disease;Funding;Goals;High Pressure Liquid Chromatography;human disease;instrument;Macromolecular Complexes;Malignant Neoplasms;mass spectrometer;Molecular;Molecular Probes;Monitor;multidisciplinary;parent project;Pathway interactions;Reaction Time;Research Personnel;Sampling;small molecule;Spottings;System;Therapeutic;tool

PROJECT_TITLE: Discovery of Molecular Probes and Therapeutic Leads


ADMINISTERING_IC: OH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: ANN ARBOR

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Research & Related Other Project Information Overall Overall. 8 Project Narrative The US workforce continues to carry a disproportionate burden of preventable job-related morbidity and mortality, resulting in part from national and regional trends that tend to adversely affect the health, safety and welfare of workers. By training high-quality practitioners and researchers, the Michigan ERC helps to meet critical shortfalls in health and safety services in most small and many larger workplaces, and thereby reduces the incidence and severity of occupational injury and illness.

PI_NAMEs: NEITZEL, RICHARD L (contact)

PROJECT_TITLE: The University of Michigan Education and Research Center


NIH_SPENDING_CATS: Neurosciences;Sleep Research

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative: Circadian rhythms are beneficial to health, whereas their disruption can increase risk of disease. The goal of this proposal is to uncover fundamental knowledge of how circadian rhythms are generated and coordinated between cells and organs outside of the brain, using genetic mouse models and molecular approaches. The knowledge gained will be critical to understand the adverse health effects associated with rhythm disruption and guide the develop of the most effective therapies to counteract circadian disruption.

PI_NAMEs: KORONOWSKI, KEVIN B (contact)

PROGRAM_OFFICER_NAME: SESMA, MICHAEL A

PROJECT_TITLE: Fundamental Mechanisms of Higher-Order Circadian Rhythms


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Iatrogenic surgical nerve injury continues to challenge even experienced surgeons, leaving patients with pain, loss of function and decreased quality of life. Our team has developed novel nerve-specific contrast agents to improve nerve identification and visualization in the surgical suite. Herein, we will investigate the utility of alternant administration routes to make integration into the clinical workflow seamless.

PI_NAMEs: GIBBS, SUMMER LYNNE (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Address;Adoption;Appointment;Blood Vessels;Cardiac;Caring;Chest;Clinical;Colorectal;Contrast Media;cost;Cranial Nerves;Critical Illness;Development;Drug Kinetics;Electrophysiology (science);Excision;experience;fluorescence-guided surgery;Fright;Healthcare Systems;Home;Hospitals;Iatrogenesis;Image;imaging capabilities;improved;injured;interest;Intravenous;intravenous administration;Knowledge;Lifelong disability;Light;loss of function;Molecular Target;Monitor;Nerve;nerve injury;Neuroanatomy;novel;operation;Operative Surgical Procedures;Oral;Orthopedic Surgery;Otorhinolaryngologic Surgical Procedures;Pain;Patients;Postoperative Period;preservation;Quality of life;Route;rural setting;Safety;Spinal;stem;Structure;subcutaneous;Surgeon;Surgical complication;Surgical Specialties;System;targeted agent;Technology;Time;tissue injury;Tissues;Travel;tumor;urologic;Vision;Visual;Visualization;Work;Workload

PROJECT_TITLE: Fluorescence guided surgery using near infrared nerve-specific probes for cranial nerve preservation

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: FAIRBANKS

ORG_NAME: UNIVERSITY OF ALASKA FAIRBANKS

ORG_STATE: AK

PI_NAMEs: BARNES, BRIAN M (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: RICHARDSON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: PROJECT NARRATIVE Emerging evidence suggests that activation of ascending projections through the right, but not the left, vagus nerve may activate dopaminergic reward circuits within the central nervous system. These recent findings raise the intriguing possibility that electrical vagus nerve stimulation (VNS) delivered to the right cervical nerve, rather than the traditionally-targeted left cervical nerve, could be used to modulate activity within these reward networks, providing novel strategies for the treatment of movement disorders. To gain further insight into the translational potential of VNS-driven dopaminergic signaling, in the current proposal, we test the neural mechanisms that underlie the neuroplasticity-promoting and behavior-reinforcing properties of VNS, and we examine the extent to which VNS-driven activation of central reward circuits is modified by experience.

PI_NAMEs: THORN, CATHERINE A (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Acceleration;Amygdaloid structure;Anesthesia procedures;Behavior;Behavioral;behavioral response;Body Weight decreased;career development;Cell Nucleus;Central Nervous System;Cervical;Cervical nerves;Chronic;clinical development;Corpus striatum structure;Data;Dependence;Desire for food;Development;Dopamine;dopamine system;dopaminergic neuron;Dose;Effectiveness;Electrodes;Epilepsy;experience;experimental group;experimental study;Exposure to;Extinction;FDA approved;Fiber;Food;Goals;Habenula;Handedness;Implant;insight;interest;Lateral;learned behavior;Learning;Left;Literature;Liver;Major Depressive Disorder;Mediating;Metabolic;Midbrain structure;Motivation;Motor;motor disorder;motor rehabilitation;Movement Disorders;Mus;nerve injury;neural;neural network;neurobiological mechanism;neuromechanism;Neuronal Plasticity;Nodose Ganglion;novel;novel strategies;Nucleus Accumbens;optical fiber;optogenetics;Organ;Pancreas;parent grant;Parents;Parkinson Disease;Pathway interactions;Peripheral Nerve Stimulation;Pharmaceutical Preparations;Phase;Photometry;Play;pre-doctoral;Prefrontal Cortex;Property;Psychological reinforcement;Publishing;reinforced behavior;Research;research and development;response;Rewards;Role;Satiation;Self Administration;sensor;Signal Induction;Signal Transduction;Stroke;Structure;Substantia nigra structure;System;Technology;Testing;Therapeutic;therapeutic development;Training;translational potential;treatment group;treatment strategy;vagus nerve stimulation;Vagus nerve structure;Ventral Tegmental Area;Viral;Viscera;Visceral

PROJECT_TITLE: Peripheral nerve stimulation for activation of dopaminergic nuclei


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: Project Narrative  NANOG directs access to stem cell pluripotency. NANOG coordinates interactions with and between key players Oct4, Sox2 and hundreds of other proteins to activate pluripotency genes and repress differentiation genes. The project will probe the fundamental molecular mechanisms of human NANOG structure and function in stem cell pluripotency.

PI_NAMEs: FERREON, JOSEPHINE CHU (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Aging;Cellular biology;Chromatin;Chromatin Loop;cofactor;Development;Differentiated Gene;Disease;Dominant-Negative Mutation;Dose;Elements;Epigenetic Process;Fluorescence;Genes;Genomics;Hi-C;Human;innovation;insight;Molecular;Molecular Probes;Peptides;Physical condensation;pluripotency;prion-like;Process;Property;Proteins;recruit;Reporting;Repression;Research Personnel;self assembly;single molecule;Stem cell pluripotency;Structure;System;Techniques;transcription factor;Work

PROJECT_TITLE: Structure and Functionof Nanog in Stem Cell Pluripotency

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative We request funding for a spinning disk microscope to advance our research on the assembly and function of cellular contractile systems. This equipment will allow for rapid 3D imaging critical for observing dynamic cellular events and overcoming current limitations due to high demand for shared resources at Vanderbilt. As such, the microscope will significantly enhance our capacity to complete the research outlined in the parent grant (R35 GM125028).

PI_NAMEs: BURNETTE, DYLAN TYLER (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 3-Dimensional;Actins;alpha Actinin;Apoptosis;Biological Models;Bulla;Cell Culture Techniques;Cell Cycle Arrest;Cell division;cell motility;Cell Physiology;Cells;Color;Confocal Microscopy;Contractile System;Cytokinesis;Embryo;Equipment;Event;experimental study;extracellular vesicles;Filament;Funding;Genetic;Goals;Grant;Housing;Image;In Vitro;in vivo;in vivo Model;Lasers;light intensity;Lighting;live cell imaging;Macromolecular Complexes;Microscope;Microscopy;Mitochondria;Mitosis;Molecular;Motion;Motor;Movement;Muscle;Myosin Type II;novel;Organelles;paralogous gene;parent grant;parent project;Parents;pharmacologic;Photobleaching;Photons;Phototoxicity;prevent;Production;Proteins;Request for Proposals;Research;Resource Sharing;Role;Sampling;Sarcomeres;solid state;Structure;superresolution imaging;System;Techniques;Testing;Three-Dimensional Imaging;Vesicle;Zebrafish

PROJECT_TITLE: The assembly and function of cellular contractile systems


NIH_SPENDING_CATS: Biotechnology;Natural Products

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE The development of new synthetic methods in organic chemistry is critical to enabling the continued discovery and production of pharmaceuticals and other chemicals that directly benefit society and public health. This proposal aims to develop a series of novel methods for C–C, C–N, and C–S bond formation that will allow for the rapid preparation of medicinally-relevant scaffolds across a variety of disease states. The newly developed reagents, and their associated reactions and applications, will be of immediate utility to synthetic chemists and chemical biologists in both academic and industrial laboratories.

PI_NAMEs: LOPCHUK, JUSTIN MATTHEW (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acceleration;Alcohols;Amines;Anions;bioactive natural products;Carboxylic Acids;chemical synthesis;Chemicals;Chemistry;Communities;Complex;Development;Diazomethane;direct application;Disease;Drug Delivery Systems;drug discovery;Fluorides;Goals;Hydrazines;Hydrogen Bonding;Industrialization;Industry;Laboratories;Link;Literature;Medicine;Methods;Molecular;Natural Products;Nitrogen;novel;Organic Chemistry;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;piperazic acid;Positioning Attribute;Preparation;Production;programs;Proteomics;Public Health;Reaction;Reagent;scaffold;Series;small molecule therapeutics;Societies;Work

PROJECT_TITLE: New reagents for C-C and C-N bond formation


ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narra+ve There have been no changes to the Project Narra2ve for the R35 GM118108 parent award.

PI_NAMEs: MONDRAGON, ALFONSO  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: biophysical analysis;Complex;Nucleic Acids;parent project;Proteins

PROJECT_TITLE: Structural and biophysical studies of proteins, nucleic acids, and their complexes

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Lysosomal damage is widely involved in many human diseases and can be triggered by various cellular stressors. Successful completion of this project will provide in-depth mechanistic understanding of how lipid remodeling contributes to lysosomal quality control and cellular homeostasis. These findings are expected to open new avenues to therapeutically intervene a wide array of lysosome-related diseases.

PI_NAMEs: TAN, XIAOJUN  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Aging;Cardiovascular Diseases;Cell Death;cell growth;Cell Membrane Permeability;Cell model;Cell Physiology;Cellular Stress;Chemicals;Cholesterol;design;Disease;Endoplasmic Reticulum;Family member;FDA approved;Functional disorder;Homeostasis;Human;human disease;improved;interest;lipid transport;lipidomics;Lipids;Lysosomal Storage Diseases;Lysosomes;Mediating;Membrane;Nerve Degeneration;Nutrient;oxysterol binding protein;Pathway interactions;phosphatidylinositol 4-phosphate;Phosphatidylinositols;Phosphatidylserines;Play;Production;Protein Family;Proteins;Proteomics;Quality Control;recruit;Recycling;repaired;response;Role;small molecule;small molecule libraries;stressor;Therapeutic

PROJECT_TITLE: Lysosomal quality control through lipid remodeling

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Prevention;Rare Diseases;Sleep Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy and thus a major public health problem. Seizures may impair arousal to important stimuli, such as CO2, to contribute to SUDEP. Understanding mechanisms for impairment of CO2-arousal in relevant animal models will importantly inform risk stratification and prophylactic strategies against this devastating disease.

PI_NAMEs: BUCHANAN, GORDON F (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acute;Administrative Supplement;Animal Model;Animals;Apnea;Arousal;Biological Markers;Carbon Dioxide;Cardiac;Cause of Death;Cell Nucleus;Cessation of life;chemical reduction;Confusion;Conscious;Data;Death Rate;Detection;Disease;dorsal raphe nucleus;dravet syndrome;Electrocardiogram;Electroencephalography;Epilepsy;epileptic encephalopathies;Etiology;experimental study;Fiber;Genetic;Goals;Impairment;Individual;insight;Intervention;Intractable Epilepsy;Life;Link;Measurable;Measurement;Measures;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Nervous System Disorder;Neurons;novel;optogenetics;Outcome;parabrachial nucleus;Pathway interactions;Patients;Phenotype;Photometry;Pilocarpine;prevent;preventive intervention;prophylactic;Public Health;Publishing;Recovery;Regulation;Research;respiratory;response;Risk;Risk Marker;risk stratification;Role;Seizures;Serotonin;Sleep;societal costs;Status Epilepticus;Stimulus;Stroke;Stupor;Sudden Death;Sudden infant death syndrome;sudden unexpected death in epilepsy;Symptoms;System;Temporal Lobe Epilepsy;Testing;Therapeutic;Wakefulness;Work

PROJECT_TITLE: Administrative Supplement to Investigate Subpopulations of the Serotonergic circuit mechanisms in postictal recovery and arousal


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: LARAMIE

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: Narrative The mission of the Wyoming Sensory Biology COBRE (SBC) is to foster and conduct high-quality scientific research that advances the understanding of our sensory systems and disorders related to them. SBC will accomplish its mission through the augmentation and strengthening of UW’s institutional biomedical research capacity by building a critical mass of investigators whose research interests are centered on sensory processes at the molecular, cellular, physiological and system levels, and by increasing the competitiveness of SBC investigators through mentoring and research support.

PI_NAMEs: SUN, QIAN-QUAN  (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Achievement;Adaptive Behaviors;Address;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Animal Model;Area;autism spectrum disorder;Awareness;Basic Science;Behavior;Biology;Biomedical Research;Cell Nucleus;Centers of Research Excellence;Child;Chronic Disease;chronic pain;Cognitive;Collaborations;Communication;cost;Development;developmental disease;Disease;Educational Activities;Evaluation;evidence base;Face;Fostering;Functional disorder;Funding;Goals;Growth;Health;Human;human old age (65+);Impairment;improved;Inflammation;innovation;Institution;interest;Journals;Knowledge;Lateral;Long-Term Care;maladaptive behavior;Manuscripts;Medial;Mental disorders;Mental Health;Mentors;Mission;Molecular;multidisciplinary;National Institute on Deafness and Other Communication Disorders;Nervous System Disorder;Neuroglia;Neurons;next generation;novel;Obesity;operation;Output;Oxytocin;parabrachial nucleus;parvocellular;Peer Review;Persons;Phase;Physiological;Positioning Attribute;Prefrontal Cortex;Process;programs;Public Health;Publications;Publishing;Recovery;recruit;Research;Research Infrastructure;Research Personnel;Research Support;Resource Sharing;Resources;responsible research conduct;Role;Scientist;Sensory;Sensory Disorders;sensory mechanism;Sensory Process;sensory stimulus;sensory system;Signal Transduction;social;Social Behavior;Spinal cord injury;System;Training;Translational Research;United States;United States National Institutes of Health;Universities;visual learning;Wyoming

PROJECT_TITLE: Wyoming Sensory Biology COBRE


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Cannabinoid Research;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The immunomodulatory impact of cannabis use in the context of the chronic inflammation experienced among people with HIV remains unclear. Previous studies on the epigenetic effects of HIV and cannabis use in heterogenous bulk cells only provide an average view of DNA methylation changes across various cell types and offer little insight into cellular epigenetic mechanism. Applying a novel computational deconvolution approach following by direct methylation sequencing validation, our goal is to identify cell-type-specific methylation aberrant sites and methylation quantitative trait loci for HIV infection and cannabis use that can be potential targets for drug repositioning.

PI_NAMEs: AOUIZERAT, BRADLEY E;XU, KE  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Address;Algorithms;antiretroviral therapy;ATAC-seq;B-Lymphocytes;Cannabis;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Separation;cell type;Cells;Chromatin;Chronic;Clinical;cohort;Computational algorithm;Data;Databases;DNA Methylation;DNA methylation profiling;drug development;drug repurposing;Drug Targeting;Drug usage;druggable target;Epigenetic Process;epigenomics;experience;Future;Gene Expression;gene interaction;Gene Targeting;Genes;Genetic;genetic variant;Genome;genome wide association study;genome-wide;genomic locus;Genotype;Goals;HIV;HIV Infections;HIV resistance;immunoregulation;In Vitro;in vivo;Inflammation;innovation;insight;Knowledge;latent HIV reservoir;Link;lonely individuals;Maps;marijuana use;Measures;Methods;Methylation;methylome;Modeling;Modification;monocyte;multiple omics;novel;novel therapeutic intervention;Overlapping Genes;Pathogenesis;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Population;Positioning Attribute;Quantitative Trait Loci;Research;Sampling;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;therapeutic target;transcriptome;treatment effect;Validation;validation studies;Work

PROJECT_TITLE: Cell-type based epigenomic analysis to identify druggable genes for people living with HIV infection and using cannabis

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 TXT-E (A1)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because one in four young adults in the U.S. identi- fies as lesbian, gay, bisexual, or transgender (LGBT), and this growing population experiences large mental health disparities relative to cisgender, heterosexual people. An unprecedented number of state policies target- ing LGBT people have become law in recent years, likely exacerbating these disparities. Revealing the needs of at-risk groups—a major priority area for the NIH—will inform interventions to reduce entrenched disparities, promote protective policies, and dramatically improve mental health.

PI_NAMEs: CHARLTON, BRITTANY MICHELLE (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adolescence;Adolescent and Young Adult;Affect;Age;Area;Behavioral Risk Factor Surveillance System;bullying;cisgender;college;community college;comparison group;Data;Discrimination;Disparity;Educational Curriculum;emerging adult;Environment;experience;gender affirming care;Goals;harassment;Health;health care availability;health disparity;health disparity populations;health inequalities;Health Personnel;health service use;Heterosexuals;improved;Individual;Institution;interest;Intervention;Interview;Laws;Lesbian Gay Bisexual;Lesbian Gay Bisexual Transgender;Link;Mediation;Mediator;Mental Health;Methods;Mind;minority stress;Minority-Serving Institution;Modeling;Outcome;Persons;Phase;Policies;Policy Maker;Population;Populations at Risk;Public Health;Quasi-experiment;Religion;Reporting;Research;Rights;Schools;Shapes;social stigma;Students;Subgroup;Surveys;teacher;Time;time use;transgender;United States National Institutes of Health;Universities;university student;Work;young adult

PROJECT_TITLE: Supportive and restrictive factors and mental health in LGBT adolescent and young adult populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-Z (57)]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Parent Narrative Clathrin-mediated endocytosis is the primary route of internalization from the plasma membrane and is required for cell viability and the proper response to extracellular cues like growth factor signaling. Mutations in the endocytic machinery, or the proteins that regulate this process, lead to a variety of diseases like cancer and neurodegeneration. This research will take an interdisciplinary approach to understand the mechanisms of endocytic initiation and cargo selection to understand CME in normal cells and how it is subverted in human disease.

PI_NAMEs: BAKER, RICHARD WAYNE (contact)

PROJECT_TERMS: Address;Area;Automobile Driving;Binding;Binding Sites;Biochemical;Biological Assay;Cell membrane;Cell Physiology;Cell Survival;Cells;Cholesterol;Clathrin;Clathrin Adaptors;Coated vesicle;Complex;Confocal Microscopy;Cryoelectron Microscopy;Cues;Data;Decision Making;Defect;Development;Disease;disease model;Dissection;drug development;Endocytosis;enhancer-binding protein AP-2;Environment;Esthesia;experimental study;extracellular;Fluorescence Microscopy;G-Protein-Coupled Receptors;Growth Factor;human disease;Image;In Vitro;insight;interdisciplinary approach;interest;Lead;Link;Lipids;live cell imaging;Malignant Neoplasms;Mediating;Medical;Membrane;Membrane Biology;Methodology;Methods;Modeling;Molecular;Molecular Conformation;multidisciplinary;mutant;Mutation;nanodisk;Nature;Nerve Degeneration;Normal Cell;Nutrient;Parents;Peptide Hydrolases;Peripheral;Phosphorylation;Phosphotransferases;preference;Process;Protein Family;Proteins;Quality Control;reconstitution;Regulation;Research;Resolution;response;Role;Route;Signal Transduction;Silicon Dioxide;single molecule;Sorting;structural biology;Structure;Systems Development;Testing;uptake;Vesicle

PROJECT_TITLE: Molecular mechanisms of endocytic initiation and cargo selection


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunization;Immunotherapy;Lymphatic Research;Orphan Drug;Rare Diseases;Vaccine Related

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE.  The overall 5-year survival rate for oral cancer has not improved much over the last few decades with both conventional multimodal treatment and emerging immunotherapies known to have an adverse (and sometimes fatal) impact on quality of life. The goal of this proposal is to develop and characterize a novel biomaterial- enhanced, living immunotherapeutic vaccine platform for oral cancer we call “EcN-IL12Vax“. This transformative approach will provide the field with an invaluable tool that can be modified and leveraged for other solid cancers in future studies and could enable further exploration of additional therapeutics with substantial toxicity at narrow concentration windows where they are both safe and effective.

PI_NAMEs: TABOR, JEFFREY JAY;VEISEH, OMID ;YOUNG, SIMON  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Adaptive Immune System;adaptive immunity;Address;Adjuvant;advanced disease;Affect;Alginates;Animals;anti-tumor immune response;Antigen-Presenting Cells;Antitumor Response;Bacteria;Biocompatible Materials;biomaterial compatibility;cancer immunotherapy;Cancer Model;cancer type;cancer vaccination;CD4 Positive T Lymphocytes;Cells;chemoradiation;Combined Modality Therapy;cytokine;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Dose;draining lymph node;Drug Kinetics;Effectiveness;Effector Cell;effector T cell;efficacy study;Encapsulated;Engineering;Escherichia coli;Excision;Flow Cytometry;Future;Generations;Genes;Goals;Human;Immune;immune checkpoint blockade;Immune response;immune-related adverse events;Immunity;Immunologics;Immunomodulators;Immunophenotyping;immunoregulation;Immunotherapeutic agent;Immunotherapy;Implant;implantation;In Situ;in situ cancer vaccine;in situ vaccination;in situ vaccine;in vitro testing;in vivo;Innate Immune System;innovation;interest;Interleukin-12;Knock-out;malignant mouth neoplasm;Malignant Neoplasms;Memory;Metastatic Neoplasm to Lymph Nodes;Microbe;Modality;Modeling;Molecular;mouth squamous cell carcinoma;Mus;Natural Immunity;Natural Killer Cells;Nature;novel;Operative Surgical Procedures;Oral;particle;pathogen;Pathway interactions;Patients;Pattern;Phenotype;Postoperative Period;predicting response;Probiotics;Production;Quality of life;recruit;Recurrence;Recurrent tumor;Resected;Residual Neoplasm;Resistance;response;Risk;Severities;Site;Solid;standard of care;Surgically-Created Resection Cavity;Survival Rate;synthetic biology;systemic toxicity;Technology;Testing;Therapeutic;tool;Toxic effect;tumor;tumor-immune system interactions;vaccine platform;Work;wound healing

PROJECT_TITLE: Engineered bacterial in situ vaccines against oral cancer.

STUDY_SECTION: TIO

STUDY_SECTION_NAME: Translational Immuno-oncology Study Section[TIO]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Identifying molecular mechanisms underlying chromosome integrity under normal physiology and during stress response is critical for our understanding of genome biology, cellular homeostasis, and physiology. This proposal will establish a leading edge on regulatory mechanisms of human genome based on our recent findings. Upon completion, this study will reveal innovative insights into the maintenance of DNA structure, stress response, and genome stability, representing a conceptual leap in our understanding of biology and cellular physiology.

PI_NAMEs: ZHANG, YOU-WEI  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Age;Aging;Biochemical;Bioinformatics;Biological;biological adaptation to stress;Biological Process;Biology;Cell Physiology;Cells;Chemicals;Chromosomes;Communication;Cues;DNA;DNA Damage;DNA Double Strand Break;DNA Maintenance;DNA metabolism;DNA Structure;Double Strand Break Repair;Evolution;Generations;Genetic;Genome;Genome Stability;Genomic Instability;Goals;Health;Heterochromatin;Homeostasis;Human;Human Genome;information processing;innovation;insight;Knowledge;Liquid substance;Malignant Neoplasms;Membrane;Molecular;Molecular and Cellular Biology;Morphology;next generation sequencing;novel;Nuclear;Nucleic Acids;p53-binding protein 1;Phase;Physical condensation;Physiology;preservation;programs;Proteins;Proteomics;Regulation;repaired;Research;Research Personnel;response;Role;Structure

PROJECT_TITLE: Supplement: 53BP1 regulates genome biology and cellular physiology through liquid phase separation


NIH_SPENDING_CATS: Bioengineering;Kidney Disease

ORG_CITY: DETROIT

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative To study the role of dysregulated renal ion transport in animal models of disease, new methods are needed to measure ion transport in the intact kidney in vivo. We propose to use multi-photon imaging of the intact kidney of live mice after transgenic expression of genetically-encoded ion sensitive probes in different nephron segments. We will express Chloride and pH-sensitive fluorescent proteins in cortical Thick Ascending Limbs, distal tubules and principal cells before performing in vivo multi-photon microscopy of renal tubular transport.

PI_NAMEs: ORTIZ, PABLO A. (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Acute;Adenoviruses;Animal Disease Models;Animals;Apical;Bumetanide;Cardiovascular Diseases;Cells;Chlorides;Chronic Kidney Failure;Coupled;Cyclic AMP;Cyclic GMP;Cytoplasm;Data;Development;Diabetes Mellitus;Distal;Distal convoluted renal tubule structure;doctoral student;Endocytosis;Epithelial Cells;Equilibrium;Fluorescence Resonance Energy Transfer;Glomerular Filtration Rate;graduate student;Homeostasis;Hydrochlorothiazide;Hypertension;Image;in vivo;inhibitor;Ion Transport;Ions;Kidney;kidney cell;kidney cortex;Kidney Diseases;Laboratories;Limb structure;Measurement;Measures;Mediating;Methodology;Methods;Micropuncture;Microscopy;Monitor;multi-photon;multiphoton imaging;multiphoton microscopy;Mus;Nephrons;Obesity;Postdoctoral Fellow;Prefrontal Cortex;promoter;Proteins;ratiometric;Regional Perfusion;renal tubular transport;response;Role;sensor;SLC11A2 gene;SLC12A3 gene;Sodium Chloride;Thick;transgene expression;Transgenic Mice;Tubular formation;two-photon;urinary;Urine;Water

PROJECT_TITLE: Measuring kidney NaCl transport in vivo with genetically encoded sensors

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Pre-mRNA splicing is essential for gene expression in all eukaryotes and errors in splicing cause genetic disorders and many other diseases. Understanding the molecular mechanism of splicing has the potential to provide useful approaches for human disease therapy.

PI_NAMEs: ZHAO, RUI  (contact)

PROJECT_TERMS: Biochemical;Complex;Coupling;Disease;Essential Genes;Esterification;Eukaryota;Exons;Gene Expression;Genetic;Genetic Diseases;Genetic Transcription;Genomic approach;Goals;human disease;Introns;Knowledge;Molecular;mRNA Precursor;protein complex;Proteins;Reaction;RNA;RNA Splicing;Small Nuclear Ribonucleoproteins;Spliceosomes

PROJECT_TITLE: Equip Supplement- Refeyn TwoMP Mass Photometer


ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors in the human genome, and they are also the proteins most widely targeted by clinically used drugs. GPCRs are implicated in many different biomedical areas, including neuropsychiatric disorders, cardiovascular disease, cancer, allergy, asthma, or pain management. The goal of this application is to develop new state-of-the-art assay technology to improve and accelerate the study and pharmacological targeting of GPCR signaling.

PI_NAMEs: GARCIA-MARCOS, MIKEL  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Acceleration;Achievement;Area;Asthma;Biological Assay;Biosensor;Cardiovascular Diseases;Cell Communication;Cell Line;Cell Surface Receptors;Cells;Clinical;Disease;drug discovery;Drug usage;extracellular;Family;Future;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Delivery;Goals;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;Hormones;Human Genome;Hypersensitivity;improved;interest;Malignant Neoplasms;Marketing;Measures;Mediating;Membrane Proteins;Methodology;neuropsychiatric disorder;Neurotransmitters;novel therapeutics;Optics;Pain management;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physiological;Physiological Processes;Physiology;Primary Cell Cultures;Protein Family;Proteins;receptor;Research;Research Personnel;Resources;response;Signal Transduction;stoichiometry;System;Technology;tool;Transfection;Transgenic Mice;vector;Viral Packaging

PROJECT_TITLE: Versatile and high-fidelity optical biosensor platforms for GPCR signaling


ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Title: Coordination of molecular motor activity in intracellular transport and assembly of cytoskeletal architecture. P.I. – Richard J. McKenney Project Narrative: Cytoskeletal motor proteins are molecular machines that transport cargos within living cells, a process critical for health and disease. How these machines are linked to specific cargo, how their motility is coordinated within the cell and how motors can also function to build large, dynamic cytoskeletal structures such as the mitotic spindle is not understood. Our research takes a reductionist approach to break down these complex cellular processes into their individual molecular components, study how the constituent molecules work in isolation, and how more complex behavior of systems of molecules arises. This proposal seeks to answer basic questions about how cells are organized with a long-term goal to provide new avenues of inquiry into the mechansims of the many diseases related to impaired molecular motor function, such as ALS, Huntington’s disease, and cancer.

PI_NAMEs: MCKENNEY, RICHARD JAMES (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Architecture;ATP Hydrolysis;Behavior;Binding;Biochemistry;Biological;Biological Assay;Cell Physiology;Cells;Cellular biology;Chemicals;Cilia;Complex;Cytoplasm;Cytoskeleton;Disease;Disparate;Dynein ATPase;Endocytic Vesicle;Environment;Eukaryota;Family;Filament;Goals;Health;Homeostasis;human disease;Huntington Disease;Impairment;In Vitro;in vivo;Individual;insight;Intracellular Transport;Kinesin;Link;Malignant Neoplasms;Microtubules;Mitochondria;Mitotic spindle;Molecular;Molecular Machines;Molecular Motors;Motility;Motion;Motor;Motor Activity;Motor output;novel;Outcome Study;parent grant;Pathologic;Process;Property;Proteins;rab GTP-Binding Proteins;reconstitution;recruit;Regulation;Research;scaffold;self assembly;single molecule;spatiotemporal;Structure;System;tau Proteins;Testing;tool;Translating;Work


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as it focuses on fundamental aspects of vertebrate devel- opment—including cell-type diversiﬁcation, self-organizing interactions and positional information—that have implications for normal patterning and homeostasis, genetic disease and birth defects, and the goals of replac- ing or repairing lost tissue through regenerative medicine. The equipment requested will enhance the laborato- ry's ability to study non-traditional models of pigmentation—marine ﬁshes—and will simultaneously allow im- provements in laboratory operations and efﬁciencies, allowing for increased research effort by highly skilled personnel. 1

PI_NAMEs: PARICHY, DAVID M (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Adult;Aging;Animals;Behavioral Assay;cell behavior;cell type;Cells;Comparative Biology;Congenital Abnormality;craniofacial;Defect;Development;Distant;Elements;Embryo;Embryonic Development;Environment;Equipment;experimental study;Fishes;Genes;Genetic;genetic analysis;Genetic Diseases;Genomics;Goals;high resolution imaging;Homeostasis;Human Genetics;Human Resources;improved;Inherited;insight;Laboratories;Location;Maintenance;Malignant Neoplasms;marine;Melanoma;Modeling;Morphology;Mutation Analysis;Neural Crest;Neural Crest Cell;novel;operation;Organ;Outcome;parent project;Pathology;Pattern;Pattern Formation;Peripheral Nervous System;permissiveness;Phenotype;Pigmentation physiologic function;Pigments;Postembryonic;postembryonic stem cell;programs;Public Health;Regenerative Medicine;repaired;Research;Role;self organization;Skeleton;skills;Skin;stem cell fate specification;stem cells;Stereotyping;teleost fish;Time;Tissues;trait;Translating;two-dimensional;Variant;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Fish facility enhancement


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: ORONO

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MAINE ORONO

ORG_STATE: ME

PHR: Project Narrative: Cloud-Based Learning Modules for Biomedical Data Science  PARENT AWARD T32GM132006 (PI: Henry, Clarissa)  The current T32 award supports an innovative, evidence-based training program that includes a co-mentorship framework and transdisciplinary research opportunities. The proposed supplement will facilitate bioinformatics and data science research training by developing reusable Cloud-based training modules to demonstrate workflows to: 1) analyze bulk RNA-Seq data to study gene expression in mouse, zebrafish and C. elegans; 2) analyze mature microRNA expression using small RNA-Seq data from mouse, zebrafish and C. elegans; 3) analyze single cell RNA-Seq data from mouse and zebrafish; and 4) modeling transcription factor networks from RNA-Seq data from human and mouse. These resources will be utilized by our T32 trainees in courses that provide instruction for running sophisticated tools with increasingly large data sets for a variety of analysis workflows, and shared with the scientific community to facilitate bioinformatics and data science research training.

PI_NAMEs: HENRY, CLARISSA A (contact);LIAW, LUCY

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TITLE: Transdisciplinary Predoctoral Training in Biomedical Science and Engineering


NIH_SPENDING_CATS: Autism;Brain Disorders;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: QUEENS

ORG_NAME: ST. JOHN'S UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE This proposal investigates the molecular basis of alternative splicing —the inclusion or skipping of different exons in mRNA— may modulates the physiological activity of CaV3.1 a voltage-gated Calcium channel that is involved in spinocerebellar ataxia, epilepsy, and autism spectrum disorders in humans. Since patients with CaV3.1-associated pathologies display defects in Calcium current properties, understanding how alternative splicing may modulate the biology of CaV3.1 and how this modulation is regulated, may have broad and significant clinical implications in spinocerebellar ataxia, epilepsy, and autism spectrum disorders, and it may inform the design of novel therapeutic strategies.

PI_NAMEs: RUGGIU, MATTEO  (contact)

PROJECT_TERMS: Absence Epilepsy;Action Potentials;Affect;Alternative Splicing;autism spectrum disorder;Binding;bioinformatics pipeline;Biological Process;Biology;Biomedical Research;biophysical properties;Biophysics;Bipolar Disorder;Brain;C-terminal;CACNA1G gene;Calcium;Calcium Channel;Calmodulin;Cardiac;career;Cell membrane;cell type;Cells;Cellular biology;Central Nervous System;Clinical;Data;Defect;design;differential expression;Disease;Epilepsy;Event;Exons;experimental study;Functional disorder;Gene Expression;Genes;Goals;graduate student;Hormonal;Human;Ion Channel;Ion Channel Gating;Kinetics;Knockout Mice;Learning;Location;Malignant hyperpyrexia due to anesthesia;Maps;Membrane;Membrane Potentials;Messenger RNA;Methodology;Migraine;Molecular;Molecular Biology;Muscle;Mutate;Mutation;Nervous System Disorder;Neurons;neurotransmitter release;novel therapeutic intervention;Pathology;Patients;Permeability;Physiological;Physiological Processes;Physiology;Play;Potassium Channel;Property;Proteins;Regulation;RNA;RNA Splicing;RNA-Binding Proteins;Role;sensor;Shapes;Signal Transduction Pathway;Spinocerebellar Ataxias;Structure;success;Testing;Thalamic structure;Timothy syndrome;Tissues;transcriptome sequencing;undergraduate student;Variant;voltage

PROJECT_TITLE: Alternative Splicing Modulates the Activity of CaV3.1, an Ion Channel Gene Involved in Spinocerebellar Ataxia, Epilepsy, and Autism Spectrum Disorders.


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CALIFORNIA STATE UNIVERSITY LOS ANGELES

PHR: Project Narrative  The parent award aims to leverage state-of-the-art data-driven models for accurate estimation of protein-ligand binding affinity that has wide applications in drug discovery. In this proposal, a modern workstation is requested in order to run machine learning models and molecular dynamics simulations more efficiently. The outcome of this research will improve the current understanding of protein-ligand interactions and will benefit the computer-aided drug design.

PI_NAMEs: FOROUZESH, NEGIN  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Acceleration;Adherence;Administrative Supplement;Affinity;Algorithms;Area;Benchmarking;Binding;Binding Proteins;Bioinformatics;Biological Process;Cells;Characteristics;Chemicals;Communicable Diseases;Complex;Computer Assisted;Computer Models;Computer Simulation;Computing Methodologies;Coupling;Data;data cleaning;Data Set;data-driven model;Databases;deep learning;deep learning model;design;DNA biosynthesis;Drug Design;drug discovery;Ensure;Equipment;experimental study;flexibility;foot;Free Energy;Gene Expression;Goals;Grant;graph neural network;GTP-Binding Proteins;Health;High Performance Computing;Human body;Hybrids;improved;laboratory experiment;Ligands;loss of function;Machine Learning;machine learning model;Manuscripts;Measures;Medicine;Methods;Modeling;Modernization;Molecular;molecular dynamics;molecular recognition;neglect;neural network;Neural Network Simulation;novel;Outcomes Research;parent project;Performance;physical model;Physics;Play;Preparation;prevent;programs;Protein Conformation;protein folding;Proteins;Protocols documentation;protonation;prototype;Research;Resources;response;Running;Sampling;Side;Signal Transduction;Signal Transduction Pathway;simulation;small molecule;Solvents;Source;Source Code;structural biology;Structure;Students;System;Testing;Training;usability;Water;web services;Weight

PROJECT_TITLE: Administrative Supplement: A Workstation for Biomolecular Simulations


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative  The goal of this project is to develop molecular recording methods to record and recover key determinants in cell-fate transitions during early development. We propose to test and optimize our methods in synthetic embryo models that mimic the early mammalian development process. We anticipate that these experiments will deepen the current model of mammalian early development and substantially advance molecular recording technology.

PI_NAMEs: CHOI, JUNHONG  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Biological Assay;Biological Models;Biology;Caenorhabditis elegans;career;Cell Lineage;Cell model;cell type;Cells;cellular development;clinical application;Complex;Data;Decision Making;design;Development;Developmental Biology;Developmental Process;DNA;Embryo;epigenomic profiling;Event;experimental study;Foundations;Gene Activation;Genetic Transcription;Genome;genome editing;Genomics;Goals;Health;Human;human genomics;improved;in vivo;insight;Link;Mammalian Cell;Maps;Measurement;Mentors;Mentorship;Methods;Microscopy;Mission;Modality;model development;Modeling;Molecular;Morphogenesis;Mus;National Human Genome Research Institute;Organism;Outcome;Phase;Positioning Attribute;post-doctoral training;Process;Recording of previous events;Regenerative Medicine;Research;Resolution;Scientific Inquiry;Signal Transduction;single cell genomics;single-cell RNA sequencing;Specific qualifier value;Structure;System;Systems Development;Techniques;Technology;temporal measurement;Testing;tool;Transcriptional Activation;transcriptome;transcriptomic profiling

PROJECT_TITLE: Molecular recording to understand the determinants of cell fate transitions in early development

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative: Within the eukaryotic cell nucleus, the human genome is associated with core histones and other proteins to form a multifaceted complex known as chromatin. This complex brings about the orderly packaging of the immense length of DNA within the tiny volume of the nucleus and is directly involved in critical cell functions. This project aims to elucidate fundamental aspects of chromatin structure, and how chromatin modifiers regulate access to DNA within chromatin and contribute to control of gene expression.

PI_NAMEs: HAYES, JEFFREY J (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acetylation;Affect;Architecture;Binding;Biochemical;Biological Models;biophysical techniques;Cell Nucleus;Cell Physiology;Chromatin;Chromatin Modeling;Chromatin Remodeling Factor;Chromatin Structure;Chromosomes;Communication;Complex;Disease;DNA;DNA Repair;Elements;Epigenetic Process;Eukaryotic Cell;Gene Expression;Genes;Genetic Diseases;Genetic Transcription;Genome;Genomic DNA;Goals;Histones;HMGN Proteins;Human Chromosomes;Human Genome;Knowledge;Length;Mediating;Modification;Molecular;Mutation;Nature;Nucleosomes;Physical condensation;Post-Translational Protein Processing;Process;Proteins;Regulation;Structure;System;Tail;Work

PROJECT_TITLE: Molecular mechanisms of the core and linker histone tail domains that drive chromatin condensation


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Project Narrative. Molecular modeling and simulations are indispensable tools in biomedical science and the drug discovery process. The proposed research will significantly enhance the capabilities of these tools in the context of computer-aided design of novel therapeutics.

PI_NAMEs: ONUFRIEV, ALEXEY VLAD (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Affinity;Algorithms;Amino Acids;Area;Binding;Binding Proteins;Binding Sites;Biological Process;Biomedical Research;Chemicals;Code;Communities;Complex;Computer software;Computer-Aided Design;conventional therapy;Coronavirus;COVID-19;current pandemic;design;Development;Disease;Disease Outbreaks;DNA;Docking;Drug Design;drug development;drug discovery;Drug Targeting;drug-like compound;experimental study;Face;fighting;Free Energy;Funding;Future;future pandemic;Gene Expression;Goals;Health;helicase;High Performance Computing;improved;in silico;Incentives;Individual;innovation;Ligands;Methodology;Methods;Modeling;models and simulation;Modernization;Molecular;Molecular Conformation;molecular modeling;next generation;novel;novel strategies;novel therapeutics;pandemic disease;pandemic potential;pandemic response;Pharmaceutical Preparations;Process;Property;protein folding;Proteins;Protocols documentation;Research;response;RNA Binding;Sampling;SARS-CoV-2 infection;Science;Signal Pathway;simulation;Site;Solvents;Speed;structural biology;Structure;Testing;theories;tool;Virus;Water

PROJECT_TITLE: Next generation implicit solvation for atomistic modeling


NIH_SPENDING_CATS: Genetics

PHR: Project Narrative: RNA structure is important in both human health and disease, including genetic diseases and infectious diseases. Here we are developing algorithms and software to predict and analyze RNA structure. This provides important information that can be used to understand disease mechanisms, target RNA with pharmaceuticals, and develop RNA-based pharmaceuticals.

PI_NAMEs: MATHEWS, DAVID H. (contact)

PROJECT_TITLE: RNA Structure Modeling Using Physics and Sequence Comparison


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cardiovascular;Cerebrovascular;Childhood Injury;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke;Unintentional Childhood Injury

ORG_CITY: PORTLAND

ORG_DEPT: PEDIATRICS

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative The proposed study will investigate cellular and molecular mechanisms of brain injury resulting from Congenital heart disease (CHD). Experiments will focus on metabolic disruptions seen in oligodendrocytes in chronic hypoxemic conditions as seen in CHD and how they contribute to white matter maturation delay and injury.

PI_NAMEs: CHAVALI, MANIDEEP  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Affect;angiogenesis;Attenuated;Autopsy;Axon;Behavioral;Birth;Blood flow;Blood Vessels;Brain;Brain Injuries;Cell Lineage;Cells;Cerebral Palsy;Cerebrum;Child;Childhood stroke;Chronic;Circulation;Cognitive;Communication;conditional knockout;Confocal Microscopy;congenital heart abnormality;Culture Techniques;Data Analyses;Data Set;Defect;Development;Disease;Doctor of Philosophy;Endothelial Cells;experimental study;fetal;Fluorescent in Situ Hybridization;Genes;Goals;graduate school;Human;Hypoxemia;Hypoxia;Image;improved;Infant;Injury;innovation;Iris;Knockout Mice;Ligands;Light;malformation;Mentors;Metabolic;Metabolic dysfunction;Metabolism;Molecular;Molecular Biology Techniques;mouse model;Myelin;myelination;Neonatal;neonatal brain;Neonatal Brain Injury;neonatal hypoxic-ischemic brain injury;neurodevelopment;Neuroglia;Neurosciences;new therapeutic target;novel;Nutrient;oligodendrocyte progenitor;Oligodendroglia;Oligonucleotides;Operative Surgical Procedures;Outcome;Oxygen;parent grant;Pathway interactions;Periventricular Leukomalacia;pharmacologic;Phase;Postbaccalaureate;Premature Birth;Process;programs;Proteins;Proteomics;Research;Research Assistant;Research Training;resilience;RNA;Rodent;Role;single molecule;skills;Slice;small molecule;Specimen;Statistical Methods;Stearoyl-CoA Desaturase;stem cells;Supporting Cell;Survivors;Technical Expertise;Techniques;Time;tool;Training;transcriptome sequencing;transcriptomics;United States;Up-Regulation;Vascular Endothelial Growth Factors;Vascularization;VEGFA gene;white matter;white matter injury

PROJECT_TITLE: Oligo-Vascular Crosstalk in the Developing Brain: Implications for White Matter Injury in Congenital Heart Disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Splicing of gene transcripts is an essential process in human cells and frequently dysregulated in disease. Despite progress, the molecular-level mechanisms of splice site identification are incompletely understood. We seek to understand how the splicing machinery identifies gene transcripts for processing into legible RNA messages, thereby providing context for personalized medicines to treat patients with dysfunctional splicing.

PI_NAMEs: KIELKOPF, CLARA  (contact)

PROJECT_TERMS: 3' Splice Site;Address;Binding;Biological Assay;biophysical techniques;Calorimetry;cancer recurrence;Cells;Co-Immunoprecipitations;Cryoelectron Microscopy;Dinucleoside Phosphates;Disease;Dissociation;Ensure;Fluorescence;Fluorescence Resonance Energy Transfer;Genes;Goals;Human;human disease;Malignant Neoplasms;Molecular;Molecular Conformation;molecular recognition;mRNA Precursor;Mutation;Neurodevelopmental Disorder;Nucleotides;Patients;personalized medicine;Phosphorylation;Process;Protein Dephosphorylation;Recurrence;response;RNA;RNA Binding;RNA Splicing;SF1;Signal Transduction;single molecule;Site;Spliced Genes;Spliceosomes;Transcript;transcriptome;U2 Small Nuclear Ribonucleoprotein;X-Ray Crystallography

PROJECT_TITLE: Molecular Recognition During Pre-mRNA Splicing

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: DAYTON

ORG_NAME: WRIGHT STATE UNIVERSITY

PHR: Project Narrative This work is relevant to public health, as current treatments for Amyotrophic Lateral Sclerosis (ALS) have limited efficacy, modest increase in lifespan, and little symptom relief. This project will examine, via electrophysiology, the mechanistic interactions between two potassium channels that are implicated in ALS excitability dysregulation. Rigorously examining how these critical regulators of excitability interact in disease could lead to novel drug targets.

PI_NAMEs: ELBASIOUNY, SHERIF M (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Affect;Affinity;Agonist;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Apamin;Bathing;Behavior;Biology;Brain Diseases;Calcium;Calcium Channel;career;clinically relevant;Closure by clamp;Data;Dependence;Disease;disease model;Electrophysiology (science);excitotoxicity;Exhibits;experimental study;Functional dependence;Functional disorder;Goals;Health;Homeostasis;improved;Individual;interest;Ion Channel;Ions;Knowledge;Kv2.1 channel;Life Extension;life span;Link;Literature;Measures;Mediating;Motor Neurons;mouse model;Mus;Nerve Degeneration;new therapeutic target;novel;Outcome;parent grant;Pathology;Performance;Pharmacologic Substance;Phosphorylation;Play;Potassium Channel;Public Health;reduce symptoms;Regulation;Research;Role;skills;Spinal Cord;Symptoms;Techniques;Testing;theories;therapeutic candidate;therapeutic target;trait;United States National Institutes of Health;voltage clamp;voltage gated channel;Work

PROJECT_TITLE: Examining the mechanistic interactions between K channels' dysfunction in rNLS8 mice


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: FRESNO

ORG_NAME: CALIFORNIA STATE UNIVERSITY FRESNO

PHR: Narrative  We hypothesize that increasing AbcA1 and Ldlr while reducing ApoE with small molecules, will diminish and clear amyloid plaques from affected brains in Alzheimer’s disease. This proposal aims at the identification of new leads that correctly modulate the three proteins. The SuRE support will enable the PI to recruit, retain, train, and motivate undergraduate and graduate research students toward building research careers via higher education.

PI_NAMEs: MAITRA, SANTANU  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Amines;Amyloid;amyloid formation;amyloid pathology;antagonist;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Apolipoproteins;appendage;Astrocytoma;ATP binding cassette transporter 1;ATP-Binding Cassette Transporters;Biological;Blood - brain barrier anatomy;Brain;brain cell;career;Carrier Proteins;Cell Line;chemical synthesis;Chemicals;Cholesterol;Dementia;Deposition;Drug Kinetics;Endocytosis;Enzyme-Linked Immunosorbent Assay;experimental study;extracellular;Genes;genetic risk factor;higher education;Human;In Vitro;in vivo;Individual;Lead;Libraries;Link;Lipids;lipophilicity;Low Density Lipoprotein Receptor;Mus;Nervous System Disorder;novel;overexpression;Pathogenesis;Pharmaceutical Preparations;pharmacophore;Phase;Play;Production;Protein Isoforms;Proteins;recruit;replication factor C;Research;Role;scaffold;screening;Senile Plaques;small molecule;Structure-Activity Relationship;Students;Sulfonamides;Therapeutic;Toxicology;Training;Transgenic Mice;undergraduate student

PROJECT_TITLE: Targeting AbcA1 and Ldlr production for the Discoveryof Alzheimer's disease Drugs


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative Statement - P30GM133894 The purpose of the P30 Resource is to provide the biomedical community with access to state- of- the-art facilities for macromolecular crystallography, small-angle x-ray scattering, and x-ray spectroscopy/imaging, tools that are essential for the study of biological systems. They enable information that is prerequisite for understanding fundamentals of life, and provide methods that are central to the development of new therapeutics for human disease. The overarching goal is to provide an integrated Resource that makes mature technologies available to a broad research community, and provides researchers with expert support in their use.

PI_NAMEs: HODGSON, KEITH O (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: absorption;Area;Automation;base;Biological;biological systems;Biomedical Research;Clinic;Collaborations;Communities;computer cluster;Computer software;computerized data processing;Cryoelectron Microscopy;Crystallography;Data;Data Analyses;Data Collection;data quality;Dedications;Detection;detector;Development;Education and Outreach;Educational workshop;experience;experimental study;Facility Accesses;flexibility;Funding;Generations;Goals;Grant;Health;Human;human disease;Image;Individual;innovation;Institution;Instruction;instrument;instrumentation;Investments;Laboratories;Leadership;Life;Light;Measurement;Membrane Lipids;Mentors;Methodology;Methods;Molecular Biology;National Institute of General Medical Sciences;new technology;novel therapeutics;online resource;operation;outreach;outreach program;Peer Review;Performance;Privatization;Process;Productivity;programs;Recording of previous events;Research;Research Personnel;Research Project Grants;Resources;Roentgen Rays;Schools;Science;Services;Site;Source;spectroscopic imaging;Spectrum Analysis;structural biology;Structure;success;synchrotron radiation;Synchrotrons;Techniques;technological innovation;Technology;theories;Time;tool;Training;United States National Institutes of Health;web portal;web-based tool;Work;X ray spectroscopy;X-Ray Crystallography;x-ray free-electron laser

PROJECT_TITLE: A Synchrotron Radiation Structural Biology Resource

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

PHR: Project Narrative The gap junctions are a class of membrane channel proteins that form direct pathways for cell-to-cell communication. Dynamic mechanisms of channel gating are required to control these communication pathways, while their misregulation is associated with a range of pathophysiological conditions, including blindness, deafness, cardiac arrhythmia, stroke and cancers. Our research group is using methods in high- resolution imaging by electron cryo-microscopy (CryoEM) to understand the detailed mechanisms of gap junction regulation and how aberrant regulation of inter-cellular communication manifests in disease.

PI_NAMEs: REICHOW, STEPHEN LOEN (contact)

PROJECT_TERMS: Address;Architecture;Arrhythmia;Biological Phenomena;Biophysics;Blindness;Brain;Cell Communication;Cells;Chemicals;Communication;Complex;Computer Models;Coupled;Cryoelectron Microscopy;deafness;Development;Disease;Environment;Gap Junctions;Hand;Heart;high resolution imaging;Imaging technology;in situ imaging;intercellular communication;Investigation;Ion Channel;Knowledge;Light;Lipids;Malignant Neoplasms;Mediator;Medical;Membrane Proteins;Methods;Molecular;Pathway interactions;pharmacologic;Physiological;Protein Biochemistry;Protein Structure Databases;Proteins;Regulation;Research;Resolution;Signal Transduction;Smell Perception;sound;Stroke;Structure;targeted treatment;Taste Perception;tool;Touch sensation

PROJECT_TITLE: Dynamic Mechanisms of Membrane Channel Gating by CryoEM


ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because defects in membrane remodeling underlie debilitating diseases from cancer to neurological disorders, and because membrane trafficking vesicles serve as the cellular entry mechanism for both harmful pathogens and therapeutic drugs. Therefore, the proposed research on the basic physical mechanisms underlying membrane remodeling is relevant to the part of NIH’s mission that seeks to develop fundamental knowledge that will help to reduce the burdens of human disability and disease. Ultimately, it is envisioned that a fundamental understanding of membrane remodeling will enable therapeutic manipulation of membrane traffic and other points of intersection between membranes and disease.

PI_NAMEs: STACHOWIAK, JEANNE CASSTEVENS (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Area;Behavior;Biological Process;Biology;Cell Physiology;Cells;Clathrin;Coupled;Defect;Diabetes Mellitus;disability;Disease;driving force;Endocytosis;Event;Filopodia;flexibility;Human;human disease;In Vitro;Individual;insight;Integral Membrane Protein;Knowledge;Liquid substance;Malignant Neoplasms;Mediating;Membrane;Membrane Protein Traffic;Mission;Modeling;Molecular;Needles;Nervous System Disorder;novel;pathogen;Pathway interactions;Pharmaceutical Preparations;pressure;Proteins;Public Health;receptor recycling;Research;Role;scaffold;Shapes;Structure;Structure-Activity Relationship;Surface;Tertiary Protein Structure;Therapeutic;trafficking;United States National Institutes of Health;Vesicle;Virus Replication;Work

PROJECT_TITLE: Protein Networks as Synergistic Drivers of Membrane Remodeling


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Public health relevance statement: Methods developed in this proposal can be applied to the preparation of bioactive compounds, which will facilitate our understanding for human diseases and the development of therapeutics.

PI_NAMEs: TANG, WEIPING  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acylation;Address;Alkylation;Binding;Biological;Biological Process;Carbohydrates;catalyst;Cell surface;cell type;chemical synthesis;Chemicals;Chimera organism;Development;Disease;extracellular;Extracellular Protein;Glycoconjugates;Glycoproteins;Glycosides;glycosylation;Goals;human disease;hydroxyl group;Hydroxyl Radical;improved;Instruction;Ligands;Lysosomes;Methods;novel;Play;Polysaccharides;Preparation;Process;programs;protein degradation;Proteins;public health relevance;receptor;receptor mediated endocytosis;Reporting;Research;Role;Series;Site;Sulfate;therapeutic development;Transition Elements

PROJECT_TITLE: Chemical Synthesis and Biological Application of Carbohydrates and Glycoconjugates - Admin Supplement


ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Pendrin (SLC26A4) is an anion transporter that is expressed in epithelial cells, e.g., in the inner ear, thyroid, kidney, and lung where it plays a central role in ion homeostasis, and it is the molecular target of the non-steroidal anti-inflammatory drug niflumic acid. Mutations in the Slc26a4 gene cause Pendred Syndrome and Enlarged Vestibular Aqueduct Syndrome (EVAS), both of which are genetic disorders characterized by early hearing loss in children and account for 5-10% of hereditary hearing loss. The physiology and pathophysiology of pendrin is poorly understood, and this project, by using structural studies in conjunction with advanced transport and binding studies, seeks to elucidate the mechanism and pharmacology of pendrin at atomic level to aid in the development of efficacious therapies.

PI_NAMEs: QUICK, MATTHIAS  (contact);ZHOU, MING

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: airway hyperresponsiveness;Anions;antagonist;Anti-Inflammatory Agents;antiport;Asthma;Bicarbonates;Binding;Binding Sites;Biological Assay;Cell membrane;Cell Volumes;Child;childhood hearing loss;Chloride Ion;Cochlea;Complex;Cryoelectron Microscopy;Development;Drug Targeting;early childhood;efficacious treatment;Epithelial Cells;Epithelium;Functional disorder;Genes;Genetic Diseases;Goals;hereditary hearing loss;Homeostasis;Homologous Gene;Human;Hydroxide Ion;Hypertension;improved;inhibitor;Iodides;Ion Exchange;Ion Transport;Ions;Kidney;Labyrinth;Lung;Membrane Lipids;Molecular Target;Motivation;Mutation;Niflumic Acid;Non-Steroidal Anti-Inflammatory Agents;novel;Pendred Syndrome;Pharmaceutical Preparations;Pharmacology;Physiology;Play;protein purification;Proteins;Reaction;reconstitution;Regulation;Reporting;Role;side effect;Sigma Factor;small molecule;stoichiometry;Structure;sulfate transporter;Syndrome;System;Thyroid Gland;Tissues;Transmembrane Domain;Transport Process;Vestibular Aqueduct

PROJECT_TITLE: Structure and mechanism of pendrin and the mutations that cause Pendred's Syndrome


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition;Obesity;Sleep Research

ORG_DEPT: BIOLOGY

PHR: Public Health Statement: Obesity and Alzheimer’s disease (AD) devastate millions of Americans and place a tremendous burden on our healthcare system. Necessities of modern society put immense pressure on human physiology by forcing incongruity between endogenous circadian rhythms and environmental cycles, which worsens a range of health issues including obesity associated maladies and AD. This project aims to identify the neuronal circuits and the molecular players that control circadian rhythms and therefore identify therapeutic targets to circumvent these pathologies.

PI_NAMEs: GULER, ALI  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Acceleration;adverse outcome;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;American;Astronomy;Behavior;behavioral response;Biological Process;circadian;Circadian desynchrony;circadian pacemaker;Circadian Rhythms;Cues;Diet;Dopamine Receptor;Dopaminergic Cell;dopaminergic neuron;Event;Exercise;Food;Food Access;food consumption;food restriction;Genetic Transcription;Goals;Health;Healthcare Systems;high risk;Hour;Human;Hypothalamic structure;insight;Laboratories;Light;Lighting;Metabolic;Metabolic Diseases;Metabolic dysfunction;Midbrain structure;Modernization;Molecular;mouse model;neural circuit;Neurodegenerative Disorders;neuronal circuitry;Neurons;novel;Obesity;Pathology;Pathway interactions;Periodicity;Persons;Physiological;Physiology;pressure;Prevalence;Public Health;Recurrence;reduce symptoms;response;Rewards;Signal Transduction;Social Interaction;Societies;Stress;suprachiasmatic nucleus;Target Populations;therapeutic target;Time;Weight Gain;Work

PROJECT_TITLE: Interplay between circadian and reward pathways in homeostatic response and pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: CHENEY

ORG_NAME: EASTERN WASHINGTON UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative The proposed project is relevant to public health because understanding gene regulation that contributes to the invasiveness and pathogenesis of Pseudomonas aeruginosa will provide alternative approaches to combat this pathogen. Therefore, the proposed project is relevant to the part of NIH's mission that pertains to developing fundamental knowledge about the nature and behavior of living systems in order to enhance health, lengthen life, and reduce the burdens of illness.

PI_NAMEs: SARWAR, ZAARA  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Adhesions;Amyloid Fibrils;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;Behavior;Binding;Binding Proteins;Binding Sites;burden of illness;Cell Adhesion;cell injury;Cells;chromatin immunoprecipitation;combat;cytotoxicity;Development;DNA Binding;DNA-Binding Proteins;enhancer binding protein;Environment;Equipment;Eukaryotic Cell;Exonuclease;Gene Expression Regulation;gene regulatory network;Genes;Genetic Transcription;Goals;Health;High-Throughput Nucleotide Sequencing;human pathogen;human tissue;Immune response;innovation;insight;Knowledge;Life;Measures;microorganism;Mission;Molecular;Nature;Nutrient;Organism;pathogen;Pathogenesis;Pathogenicity;Peroxides;Proteins;Pseudomonas aeruginosa;Public Health;Regulation;Regulon;Resistance;resistance mechanism;Role;Signal Transduction;Tissues;trait;transcriptome;transcriptome sequencing;United States National Institutes of Health;Virulence

PROJECT_TITLE: Equipment Supplement for 7R15GM150043-02: The role of master regulator NtrC in amyloid fibril dependent pathogenic traits of Pseudomonas aeruginosa


ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Phase II COBRE funding will strengthen and enhance the Dartmouth Institute for Biomolecular Targeting, which supports innovative strategies to enhance understanding of biological mechanisms and translation of that knowledge into clinical practice. The Institute will continue to catalyze the development of new therapeutic approaches to address cancer, respiratory infections, and other diseases. It also provides unique resources to investigators at Dartmouth and our IDeA partners, enhancing research productivity and funding competitiveness across the region.

PI_NAMEs: MADDEN, DEAN R (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Antibodies;Area;Autophagocytosis;Award;Awareness;Binding;Biological;Businesses;career;Career Mobility;Centers of Research Excellence;clinical practice;cohort;Communities;community building;Complex;Consultations;Core Facility;cost;Cryoelectron Microscopy;Cystic Fibrosis;Dedications;Development;Diabetes Mellitus;Disease;Disparate;diversity and inclusion;drug development;Drug Targeting;Equipment;experience;Extramural Activities;Faculty;Faculty Recruitment;faculty research;faculty support;fascinate;Financial Support;forging;Fostering;Foundations;fundamental research;Funding;Future;Generations;Goals;Grant;Home;Image;Immunologics;Infection;Infrastructure;innovation;Institution;instrument;instrumentation;interest;Investigation;Investments;Ion Channel;knowledge translation;Malignant Neoplasms;Mass Spectrum Analysis;member;Membrane Fusion;Mentors;Metabolic Control;Microscope;Microscopy;mid-career faculty;Modeling;Molecular;molecular imaging;Molecular Target;Neoplasm Metastasis;new technology;novel therapeutic intervention;operation;Pathology;Phase;Play;Postdoctoral Fellow;pre-clinical;preclinical development;Production;Productivity;Program Reviews;programs;Protein Biochemistry;protein expression;Proteins;Recovery;recruit;Research;Research Institute;Research Personnel;Research Project Grants;Resources;Respiratory Tract Infections;Role;Schools;Scientist;Seasons;Series;Services;Signal Transduction;Subgroup;success;symposium;Targeted Research;Teacher Professional Development;Technology;Testing;Therapeutic;therapeutic target;Time;tool;translational goal;Translations;tumor progression;Vaccines;Virus Diseases;Work

PROJECT_TITLE: The Institute for Biomolecular Targeting - Equipment Supplement 2024


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARATIVE The new Refeyn TwoMP Mass Photometer provides a highly sensitive technology to analyze single biomolecules in solution and is label-free. Yielding accurate mass measurements in under five minutes and for about $1 per measurement, the new mass photometer will directly benefit the parent project’s research plan to study the oligomeric state(s) and assembly of protein machines in equilibria and to optimize sample conditions prior to structure analysis work. The TwoMP Mass Photometer will strengthen our research capabilities and provide enhanced user access to this powerful technology, but it is currently not available at Baylor College of Medicine or in the greater Houston area.

PI_NAMEs: TSAI, FRANCIS T.F. (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Administrative Supplement;Area;Behavior;Biochemical;Biochemistry;college;Complex;Consumption;cost effective;Dedications;Equipment;Funding;Institution;Label;Laboratories;light scattering;macromolecule;Maintenance;Measurement;Measures;Medicine;Methods;Mitochondria;Molecular Chaperones;molecular mass;Nature;new technology;parent project;Parents;Photometry;Preparation;prevent;Proteins;Rapid screening;Research;Research Personnel;Research Project Grants;Sampling;single molecule;Structure;Technology;three dimensional structure;Time;Work

PROJECT_TITLE: Structure, Function, and Mechanism of a Mitochondrial Chaperone