ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Project Narrative New therapeutics are desperately needed for the treatment of diseases with unmet needs, such as infectious and immunological diseases. This proposal uses an ecology-driven approach to discover new drugs from the microbiome of marine egg masses, which have ecological pressures that are predicted to have driven the evolution of novel antibiotics and immunomodulating agents. Chemical investigations into egg mass symbionts will lead to the discovery of novel chemistry and has the potential to repopulate the drug pipeline.

PI_NAMEs: MEVERS, EMILY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Anti-Infective Agents;Antibiotics;Biological Assay;Chemicals;Chemistry;Clinic;Communicable Diseases;Communities;Complex;Culture Techniques;Development;Disease;Drops;drug candidate;drug discovery;Ecology;Ecosystem;egg;Emerging infection;Environment;Evolution;Gene Cluster;Goals;Human;immune modulating agents;Immune System Diseases;immunoregulation;in vivo;Infection;innovation;Investigation;Laboratories;Libraries;marine;Mass Spectrum Analysis;metabolomics;Microbe;microbial;microbiome;microbiota;microorganism;Natural Products;Nature;novel;novel therapeutics;Nuclear Magnetic Resonance;Organism;Pharmaceutical Preparations;Play;pressure;programs;Recording of previous events;Regulation;Research;Rodent Model;Role;small molecule;Source;Structure;success;symbiont;Techniques;Therapeutic

PROJECT_TITLE: Unlocking the biomedical potential of microbial symbionts from complex ecosystems


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Dental, Oral, and Craniofacial Disease;Headaches;Immunotherapy;Migraine;Neurosciences;Pain Research

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANESTHESIOLOGY

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Our previous work shows that restoring the balance between regulatory T cells and other immune cells can effectively reverse chronic migraine-related behavioral and cellular sensitizations in mice. In this application, we propose to test the hypothesis that neuro-immune interactions contribute to the chronification and resolution of migraine headache through regulating the activity of primary afferent neurons in the trigeminovascular pathway. This will elucidate the mechanisms underlying migraine chronification and help developing new therapeutic strategies.

PI_NAMEs: CAO, YUQING  (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Adoptive Transfer;Afferent Neurons;Autoimmune Diseases;Behavioral;behavioral sensitization;Calcitonin Gene-Related Peptide;CD3 Antigens;CD8-Positive T-Lymphocytes;Cells;cellular sensitization;cellular targeting;Cervical;Chronic;Chronic Headaches;conditional knockout;Defect;Development;Disease;dorsal horn;Dose;drug discovery;Dura Mater;Equilibrium;Exhibits;experimental study;Face;face skin;Flow Cytometry;FOS Protein;Foundations;Functional disorder;Functional impairment;Future;Headache;Hypersensitivity;IL2 gene;Image;Immune;immune activation;Immunohistochemistry;Immunosuppression;Inflammatory;insight;Interleukin-10;Interleukin-2;Knock-out;knockout gene;Knockout Mice;Knowledge;Maintenance;Measures;Mediating;Meningeal;Microglia;Migraine;migraine treatment;Modeling;Molecular Target;mouse model;Mus;Neuroimmune;Neurons;Neuropeptides;Nitroglycerin;nociceptive response;novel;novel therapeutic intervention;Pathogenesis;Pathway interactions;Patients;Peptides;Peripheral;peripheral blood;pituitary adenylate cyclase activating polypeptide;polypeptide;R peptide;Recurrence;Regulatory T-Lymphocyte;Resolution;response;Signal Pathway;Signal Transduction;Source;Stains;Stimulus;Structure of trigeminal ganglion;Subgroup;T-Lymphocyte;T-Lymphocyte Subsets;Testing;TGFB1 gene;Tissues;Transforming Growth Factor beta;Translational Research;Work

PROJECT_TITLE: Mechanisms of migraine chronification and reversal

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: The synaptic plasticity and memory hypothesis asserts that memory is stored by learning-induced functional modifications at a subset of the synapses of the neurons that are activated to encode the learning experience. We will critically test the hypothesis by tracing which synaptic populations persistently strengthen after formation of a specific place memory, by optogenetically activating and recording the discharge of a subset of the hippocampal neurons that encode the memory after control and inhibiting manipulations of the molecular tracer, which is the currently best validated molecular mechanism that is demonstrated to be necessary for persistent synaptic plasticity and long-term memory storage in these neurons.

PI_NAMEs: FENTON, ANDRE ANTONIO (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Affect;Amnesia;Animals;Anisomycin;avoidance behavior;Behavior;behavior test;Behavioral;Brain;Cartoons;Cells;Chemosensitization;Code;Collection;Compensation;conditioned fear;conditioning;Dendritic Spines;density;Discipline;educational atmosphere;Electrophysiology (science);experience;fear memory;Genes;Genetic;genetic manipulation;Genetic Recombination;Hippocampus;Homosynaptic Depression;information processing;Label;Learning;Light;long term memory;Maintenance;Measures;Memory;memory acquisition;memory encoding;Modification;Molecular;molecular marker;Mus;N-Methyl-D-Aspartate Receptors;neural;neural stimulation;Neurons;optogenetics;Oranges;Outcome;Periodicals;pharmacologic;Phosphotransferases;Physiological;Population;preservation;prevent;Prevention;Protein Biosynthesis;Protein Kinase M;response;Retrograde amnesia;Role;Role Concepts;Structure;Synapses;Synaptic plasticity;Technology;Testing;Text;timeline;Tracer;Uncertainty;Vertebral column

PROJECT_TITLE: Towards a critical test of the synaptic plasticity and memory hypothesis

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Genetics;Liver Disease;Prevention;Prostate Cancer;Urologic Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The proposed project seeks to advance public health by improving the very poor survival rate of patients with prostate cancer (PCa) due to the presence of metastases and no available curative therapies. Our research will identify alterations causing PCa to spread to other tissues by tracking the metastatic clones as they develop using our new model system, EvoCaP, both in the presence and absence of standard therapy. By identifying genes and pathways that cause PCa to spread and colonize different organs, our project is designed to ﬁnd new, vital drug targets previously missed by traditional methods of identiﬁcation, to treat advanced forms of metastatic PCa.

PI_NAMEs: NOWAK, DAWID GRZEGORZ (contact)

PROGRAM_OFFICER_NAME: BENAVIDEZ, JUSTIN MICHAEL

PROJECT_TERMS: Accounting;Address;Affect;Aftercare;androgen deprivation therapy;animal breeding;Animal Model;Animals;Architecture;Automobile Driving;Bar Codes;Biological Models;bone;cancer cell;Cancer Prognosis;Cancer Relapse;cancer site;cancer therapy;Castration;Cells;Cessation of life;Clonal Evolution;Clonal Expansion;Computer Models;Computing Methodologies;Consumption;curative treatments;Data;design;Development;Disease;Disease Progression;disorder control;Disseminated Malignant Neoplasm;drug development;Drug Targeting;Early Diagnosis;Evolution;flexibility;Fluorescence;Gene Expression Profiling;Genes;genetic signature;Genomics;Goals;Growth;Guide RNA;Heritability;Hormones;Human;Immune system;improved;Interruption;Intervention;knock-down;Knowledge;Liver;luminescence;Lung;lymph nodes;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;man;Maps;men;Metastatic Neoplasm to the Liver;Metastatic Prostate Cancer;Methods;migration;Modeling;Molecular;Molecular Evolution;mortality;mouse model;Mutation;MYC gene;Neoplasm Metastasis;novel;Organ;Outcome;Pathway interactions;Patients;Pattern;Phase;Phenotype;Phylogenetic Analysis;Physiological;Population;postnatal;pressure;prevent;Primary Neoplasm;Probability;Process;Prostate;prostate cancer metastasis;prostate cancer model;Prostate Cancer therapy;Proto-Oncogenes;PTEN gene;Public Health;RB1 gene;Research;Research Technics;Resistance;resistance mechanism;RNA;Site;small hairpin RNA;Somatic Cell;Sorting;Survival Rate;System;targeted cancer therapy;Technology;Testing;Therapeutic;Time;Tissues;TP53 gene;Trees;tumor;tumor heterogeneity;Tumor Suppressor Proteins

PROJECT_TITLE: "Novel Mouse Models for Quantitative Understanding of Baseline and Therapy-Driven Evolution of Prostate Cancer Metastasis"

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-B(55)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Lung;Lung Cancer;Radiation Oncology

ORG_CITY: MAYWOOD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: Public Health Relevance/Narrative The management of lung tumor motion, due to respiration, during radiation therapy is an unsolved clinical problem. The use of dual energy imaging, in conjunction with markerless lung tumor tracking, will provide a more accurate treatment to the tumor and decrease the volume of normal lung irradiated, reducing the risk of radiation induced complications.

PI_NAMEs: LEHMANN, MATHIAS ;ROESKE, JOHN  (contact)

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: 3-Dimensional;Address;Anatomy;Area;bone;Bone Tissue;cancer imaging;chemotherapy;Chronic Obstructive Pulmonary Disease;Clinical;clinical development;clinical implementation;clinical practice;cohort;Communities;comorbidity;Compensation;cone-beam computed tomography;contrast imaging;cost effective;Development;Devices;digital;Discrimination;Disease Management;Dose;Electromagnetics;Engineering;Ensure;Environment;Excision;feasibility testing;Fluoroscopy;Funding;Goals;Grant;Hemorrhage;Image;image guided;imager;imaging capabilities;imaging modality;imaging study;implantation;improved;Incidence;Individual;industry partner;innovation;Institution;irradiation;Length;Linear Accelerator Radiotherapy Systems;Liver;logarithm;Lung;lung imaging;Lung Neoplasms;lung volume;Lung Volume Reductions;Malignant neoplasm of lung;Malignant Neoplasms;manufacturing capabilities;Methods;Modality;Motion;Normal tissue morphology;Operative Surgical Procedures;Patients;Pneumothorax;Positioning Attribute;programs;Protocols documentation;public health relevance;quality assurance;radiation delivery;Radiation Pneumonitis;radiation risk;Radiation therapy;radiological imaging;reconstruction;Research;Research Personnel;Respiration;respiratory;Risk;Risk Reduction;Roentgen Rays;soft tissue;success;Sum;System;Techniques;Technology;technology validation;Testing;Therapeutic;Time;Tissues;tomosynthesis;tool;tumor;Validation;Visualization;X-Ray Medical Imaging

PROJECT_TITLE: Markerless Motion Tracking of Lung Tumors using Dual Energy Imaging


ADMINISTERING_IC: DK

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Infectious Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition;Prevention

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: NUTRITION

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE It is widely accepted that long-term intake of ultra-processed foods has detrimental effects on host intestinal health; however, the underlying mechanisms by which processed ingredient diet escalates susceptibility to intestinal inflammation are ill-defined, thus preventing us from devising a dietary-based intervention(s) to reduce the onset and occurrence of inflammatory bowel disease (IBD). Our preliminary observation demonstrates that the processed ingredient diet (chiefly comprised of refined starch, sugar, and fat but lacking in whole grain contents) increases the propensity to develop IBD by impairing the host mucosal immune responses against invading (opportunistic) microorganisms in the gut. This proposal seeks to further investigate this exciting novel observation, address the potential underlying mechanisms, and identify processed diet-linked microbial metabolites that escalate susceptibility to IBD.

PI_NAMEs: SINGH, VISHAL  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Acute;Address;American diet;Attenuated;Autophagocytosis;Bacteria;Bile Acids;Binding Proteins;Cells;Chronic;Colitis;Colon;colon bacteria;Country;Crohn's disease;Data;deoxycholate;Development;dextran sulfate sodium induced colitis;Diet;dietary;Dietary Fiber;Disease susceptibility;enteric pathogen;Environmental Risk Factor;epidemiologic data;Exhibits;Family;Fatty acid glycerol esters;feeding;Fiber;Food;Fortified Food;Genes;Genetic Transcription;genome wide association study;Goals;Grain;Guanosine;guanylate;gut inflammation;gut microbiota;Health;High Prevalence;high risk;Homeostasis;Host Defense;Host resistance;Human;Hydrogenation;Immune;Immune system;Immunity;Impairment;Incidence;Individual;Infectious colitis;Inflammasome;Inflammatory Bowel Diseases;Intake;Interferon Type II;Interferons;interleukin-10 receptor;Intervention;Intestines;Invaded;Link;Mediating;Metabolic;Microbe;microbial;microbiota composition;microorganism;Modeling;Mucosal Immune Responses;Mucosal Immunity;Mucous body substance;Mucous Membrane;Mus;Names;non-genetic;novel;Onset of illness;Organoids;pathogen;pathogenic bacteria;Pathway interactions;Play;Predisposition;Prevalence;prevent;Process;Proteins;Public Health;receptor;Recombinant Interferon;Reducing diet;Regulation;Reporting;Repression;Resistance;Risk;risk variant;Role;Severities;Sodium Dextran Sulfate;Starch;sugar;System;Testing;United States

PROJECT_TITLE: Interplay of processed diet, gut microbiota, and interferon-linked mucosal immunity in the onset and prevalence of inflammatory bowel disease

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ORG_DEPT: SURGERY

PHR: Project Narrative An oncogenic kinase, ACK1, phosphorylates the ATP synthase alpha-subunit, preventing binding of its physiological inhibitor, IF1, enhancing ATP synthesis in cancer cells. This `resourceful’ version of oxidative phosphorylation employed by cancer cell wherein phospho-ATP5F1a directs undiminished ATP synthesis likely to support progression of prostate cancer to malignant stage. Treatment of cancer cells with (R)-9b promoted IF1 binding, leading to significant reduction in ATP levels and initiated a distinct mitophagic response, uncovering a new category of tyrosine kinase inhibitor targeting mitochondrial metabolism specifically in cancers.

PI_NAMEs: MAHAJAN, NUPAM P (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: abiraterone;Ablation;ACK1 Gene;Acute;addiction;Adenocarcinoma;aerobic glycolysis;androgen independent prostate cancer;Androgen Receptor;antagonist;arm;ATP phosphohydrolase;ATP Synthesis Pathway;Binding;Biochemical Pathway;Bioenergetics;Biological Assay;Biomass;Blood;cancer cell;cancer therapy;Caspase;Categories;Cause of Death;Cells;Clinical;CRISPR/Cas technology;Data;Dependence;Disease remission;enzalutamide;Enzyme Stability;Enzymes;Evaluation;Event;Exclusion;Exhibits;flexibility;Generations;Genetic;Genus Hippocampus;Gluconeogenesis;Heterogeneity;Hypoxia;Immunohistochemistry;In Situ;in vivo;Individual;inhibitor;Knock-in;Knockout Mice;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;men;Metabolic;metabolic phenotype;Mites;Mitochondria;mitochondrial DNA mutation;mitochondrial metabolism;Molecular;mouse model;Mus;Mutation;Nucleotides;old mice;Oncogenes;Oncogenic;Oxidative Phosphorylation;Oxygen Consumption;Pathway interactions;patient derived xenograft model;Phosphorylation;Phosphotransferases;Physiological;Point Mutation;prevent;probasin;Process;Production;Proliferating;promoter;Property;Prostate;prostate cancer model;prostate cancer progression;Prostatic Intraepithelial Neoplasias;Protein Tyrosine Kinase;Proteins;PSA level;Reactive Oxygen Species;Regulation;Resistance;Resistance development;response;Role;Signal Pathway;Signal Transduction;Specificity;Stress;Structure;Substrate Specificity;Surface;Therapeutic;Transgenic Mice;tumor;tumor growth;Tumor Suppressor Proteins;Tumor Volume;tumor xenograft;Tyrosine Kinase Inhibitor;VCaP;Warburg Effect;Weight;Western Blotting

PROJECT_TITLE: Regulation of Mitochondrial Metabolism by Tyr-phosphorylated ATP Synthase Alpha-Subunit and its Therapeutic Implications in Prostate Cancer


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Adenylyl cyclase, the focus of the proposed study, modulates cyclic AMP, a molecule that is vital to modulating many pathways throughout human physiology. Significant pathological consequences, including cancer, chronic obstructive pulmonary disease, neuropsychiatric disorders, diabetes, heart disease, and drug abuse result from aberrant signaling of cyclic AMP. Thus, adenylyl cyclases hold great potential as therapeutic targets in disease, but our current understanding of the basic biology of these enzymes is lacking.

PI_NAMEs: PAPASERGI, MAKAIA M. (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: A kinase anchoring protein;Address;Adenylate Cyclase;Architecture;Arrhythmia;beta-2 Adrenergic Receptors;Biochemical;Biological Assay;Biology;Cells;Cellular biology;Cellular Morphology;Chronic Obstructive Pulmonary Disease;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Development;Diabetes Mellitus;differential expression;Disease;Drug abuse;Environment;Enzymes;experience;flexibility;Fluorescence Microscopy;Funding;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;genetic regulatory protein;Glaucoma;Goals;GTP-Binding Protein alpha Subunits, Gs;GTP-Binding Proteins;Heart Diseases;Human;Hyperthyroidism;In Situ;In Vitro;in vivo;Label;Laboratories;Length;Lipids;Macromolecular Complexes;Malignant Neoplasms;Membrane;Mentors;Methodology;Methods;Migraine;Modeling;Molecular;Morphology;Multiple Partners;nanodisk;neuropsychiatric disorder;novel;Outcome;particle;Pathologic;Pathway interactions;Pharmacologic Substance;phosphoric diester hydrolase;Physiological;Physiology;Positioning Attribute;programs;Protein Biochemistry;Protein Isoforms;protein purification;Protein Subunits;Proteins;Proteomics;receptor;reconstitution;Research;Research Personnel;Resources;response;Scaffolding Protein;Series;Signal Pathway;Signal Transduction;spatiotemporal;structural biology;Structure;Therapeutic;therapeutic target;Training;Tremor;Visualization;Work

PROJECT_TITLE: Spatiotemporal visualization of adenylyl cyclase signaling

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(JA)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Microbiome;Nutrition

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Bacteroides thetaiotaomicron is a prominent member of the mammalian gut. This proposal examines how novel forms of three conserved regulatory proteins govern gut colonization in this commensal bacterium.

PI_NAMEs: GROISMAN, EDUARDO  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Achievement;Bacteroides thetaiotaomicron;Biochemical;Biological;Carbohydrates;commensal bacteria;Complex;Diet;Dietary Sugars;differential expression;Engineering;Escherichia coli;Fructose;Genes;genetic regulatory protein;Genetic Transcription;Glucose;Growth;GTP-Binding Proteins;Guanosine Triphosphate;gut bacteria;gut colonization;gut microbiota;Health;Human;In Vitro;in vivo;Individual;Investigation;Liquid substance;Mediating;member;Messenger RNA;model organism;Mus;novel;Nutrient;paralogous gene;Peptide Elongation Factor G;Phase;Physical condensation;Polysaccharides;Property;Protein Biosynthesis;Proteins;Recycling;Research;rho;Rho Factor;Ribosomes;Role;Signal Transduction;Starvation;sugar;termination factor;Testing;Thinness;transcription termination;translation factor;uptake

PROJECT_TITLE: Control of gut colonization by the prominent gut bacterium Bacteroides thetaiotaomicron

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: CHAPEL HILL

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Public Health Relevance: Heart disease is the leading cause of morbidity and mortality in the United States. This proposal aims to delineate the role of macrophage functional dynamics in adult heart regeneration for the purpose of improving understanding of cardiac disease and facilitating the search for treatments.

PI_NAMEs: LIU, JIANDONG  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Acceleration;Acute;Address;Adult;Affect;Alternative Splicing;Antibodies;Basic Science;Behavior;Binding;Biological;Biological Process;Biology;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiogenesis;Cell Communication;cell determination;cell type;Cells;Chromatin;Cicatrix;Communication;Complex;CRISPR/Cas technology;Data;Data Analyses;Development;Endothelial Cells;Event;Exhibits;Fibroblasts;Functional disorder;Future;Gene Expression;Genetic;genetic manipulation;Genetic Markers;Genomic approach;Health;Heart;heart damage;Heart Diseases;Heart failure;Homeostasis;Human;Immune;immune function;Immunologic Surveillance;improved;Individual;Inflammation;Inflammatory;Inflammatory Response;insight;Label;Macrophage;Messenger RNA;Molecular;Morbidity - disease rate;mortality;mutant;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Myocardium;Natural regeneration;Outcome;Phenotype;Physiology;Play;Population;Process;Proliferating;public health relevance;Publishing;regenerative;Regenerative capacity;Research Proposals;Resolution;response;RNA;RNA Splicing;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Spatial Distribution;Study models;Testing;therapeutic development;Therapeutic Intervention;Time;TNF gene;tool;transcription factor;Transcription Factor AP-1;Transcriptional Regulation;transcriptome;transcriptomics;Transgenic Organisms;United States;Zebrafish

PROJECT_TITLE: Macrophage functional dynamics in adult heart regeneration

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Patients with gastrointestinal (GI) cancers that metastasize to the peritoneal cavity suffer high morbidity and mortality and have few effective treatment options. Mutations in the GNAS gene are associated with higher rates of peritoneal metastasis, as well as decreased responses to chemotherapy in many GI cancers. The study will investigate the impact of GNAS mutations on tumor molecular signaling cascades and tumor progression, improve fundamental knowledge of tumor peritoneal metastasis, and evaluate GNAS inhibition as a new promising treatment strategy for the large number of patients with metastatic GI cancers.

PI_NAMEs: FOOTE, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Adenylate Cyclase;Advisory Committees;Arginine;Award;Bioinformatics;Cancer Patient;cancer type;Carcinomatosis;Cells;Chemoresistance;chemotherapy;Clinical Trials;cohort;CRISPR/Cas technology;Data;Development;Development Plans;Disseminated Malignant Neoplasm;DNA;Down-Regulation;drug development;Drug Targeting;Educational workshop;effective therapy;Epidemiology;Exhibits;Experimental Models;experimental study;Fingers;Future;gain of function;gain of function mutation;gastrointestinal;Gastrointestinal Neoplasms;Gene Expression;gene regulatory network;Genes;Genomics;Goals;Greater sac of peritoneum;Growth;GTP-Binding Protein alpha Subunits;Guanosine Triphosphate;high risk;Hydrolysis;Impairment;improved;In Vitro;in vivo;inhibitor therapy;innovation;International;Investigation;Knowledge;KRAS2 gene;Lung Neoplasms;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;MAP Kinase Gene;Memorial Sloan-Kettering Cancer Center;Mentors;Modeling;Molecular;Molecular Analysis;Molecular Biology;Molecular Conformation;molecular phenotype;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;Mucinous;Mucins;multiple omics;Mus;mutant;Mutate;Mutation;Neoplasm Metastasis;novel therapeutic intervention;oncology service;Organoids;Pancreas;Pathogenicity;Patients;Pattern;Peritoneal;Phenotype;Physicians;PIK3CG gene;Production;Recurrence;response;RNA;Role;Scientist;Signal Pathway;Signal Transduction;targeted treatment;Testing;Therapeutic;Therapeutic Effect;TP53 gene;Training;translational physician;Translational Research;treatment response;treatment strategy;Tropism;tumor;tumor DNA;tumor progression;Tumor Suppressor Proteins;Validation;Xenograft procedure

PROJECT_TITLE: Defining the role of GNAS in gastrointestinal metastasis

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Brain Disorders;Cannabidiol Research;Cannabinoid Research;Cerebrovascular;Endocannabinoid System Research;Epilepsy;Natural Products;Neurodegenerative;Neurosciences;Therapeutic Cannabinoid Research

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: The proposed research is relevant to public health because it is expected to provide mechanistic and preclinical data supporting future research for the clinical translation of CBD to treat patients with epilepsy. Thus, the proposed research is relevant to the mission of the NINDS that pertains to developing fundamental knowledge that will help reduce the burden of neurological disease.

PI_NAMEs: BAUER, BJOERN  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: 2-arachidonylglycerol;Acute;Address;Animal Model;Anticonvulsants;Arachidonate 5-Lipoxygenase;Automobile Driving;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood capillaries;Cannabidiol;Cannabinoids;Cannabis sativa plant;cerebral capillary;Characteristics;Childhood;Chronic;Clinical;clinical translation;CNR1 gene;cyclooxygenase 2;Data;Endocannabinoids;Endothelium;Enzymes;Epilepsy;Extravasation;Feedback;Functional disorder;Generations;glutamatergic signaling;Glutamates;Human;improved;in vivo;in vivo Model;Inflammation;Inflammatory;innovation;Knockout Mice;Knowledge;Link;Lipoxygenase;Marketing;Mediating;Medical;metabotropic glutamate receptor type 1;Mission;mouse model;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurons;neurovascular;novel therapeutic intervention;Outcome;Patients;Pharmacology;Policies;pre-clinical;prevent;Public Health;Rattus;repaired;Research;Science;Seizures;Signal Transduction;Testing;Therapeutic;Therapeutic Agents;translational potential;United States National Institutes of Health;Work

PROJECT_TITLE: Mechanism and Therapeutic Potential of CBD to Repair Blood-Brain Barrier Dysfunction in Epilepsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MDCN-M(91)]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Gene Therapy;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative Neurodegenerative disorders, including Huntington's disease and amyotrophic lateral sclerosis, represent a major class of diseases with unmet medical needs. Therapeutic oligonucleotides are promising sequence- specific drugs for the treatment of genetically defined neurodegenerative disorders, but their use is limited by the lack of safe and effective delivery methods, especially for the brain. The goal of this proposal is to develop novel oligonucleotide chemistry platforms to inhibit toxic gene expression in the brain and spinal cord.

PI_NAMEs: KHVOROVA, ANASTASIA  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Acetylgalactosamine;Affect;Alleles;Amyotrophic Lateral Sclerosis;Animal Model;Antisense Oligonucleotides;Architecture;Asialoglycoprotein Receptor;Bacterial Artificial Chromosomes;Behavior;Behavioral Assay;Biochemical;Biological Assay;Brain;Brain region;C9ORF72;Cell Nucleus;Central Nervous System;Cerebrospinal Fluid;cerebrospinal fluid clearance;Chemicals;Chemistry;Clinic;Clinical;combinatorial;Complex;Corpus striatum structure;Cytoplasm;Development;Disease;disease model;Dose;Etiology;Evaluation;Exhibits;Funding;Gene Combinations;Gene Expression;Gene Expression Regulation;gene function;gene product;Gene Silencing;Gene Targeting;Genes;Goals;Grant;Huntington Disease;improved;In Situ Hybridization;In Vitro;in vivo;in vivo Model;Injections;innovation;Investigation;Laboratories;Ligands;lipophilicity;Liver;Liver diseases;Measures;Mediating;Medical;Messenger RNA;Metabolic;Methods;Modeling;Molecular;MSH3 gene;mutant;National Institute of Neurological Disorders and Stroke;Neurodegenerative Disorders;Neurons;new technology;nonhuman primate;novel;Nuclear;Nucleic Acids;oligonucleotide therapeutics;Oligonucleotides;Outcome;Pharmaceutical Preparations;Pharmacotherapy;prevent;Regimen;research clinical testing;Rodent;Safety;Sheep;Small Interfering RNA;Specificity;Spinal Cord;Structure;superoxide dismutase 1;Technology;technology platform;Therapeutic;therapeutic candidate;Therapeutic Effect;Therapeutic Index;therapeutic siRNA;Tissues;Toxic effect;Transcript;uptake;Variant;Vertebral column;Work

PROJECT_TITLE: Expanding the Chemical Diversity of Therapeutic Oligonucleotides

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Difficulties in employment and postsecondary education among young adults with autism spectrum disorder are nearly universal, with challenges both in obtaining and maintaining these positions. Yet, almost nothing is known about the factors that promote postsecondary employment/educational stability, resulting in a dearth of evidence-based interventions and programs to support sustained participation. The proposed research will have high public health impact by providing new knowledge that can be rapidly translated into novel interventions to support young adults with autism spectrum disorder in maintaining employment/educational positions.

PI_NAMEs: DAWALT, LEANN SMITH;TAYLOR, JULIE LOUNDS (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Adaptive Behaviors;Adolescent;Adult;Age;autism spectrum disorder;Characteristics;Climate;college;Communities;community-level factor;Data;Data Collection;Data Sources;design;Diagnostic;Education;Educational Activities;educational atmosphere;Employment;Enrollment;Evaluation;Evidence based intervention;experience;Family;General Population;Health;Heterogeneity;high school;Hour;Income;Individual;individuals with autism spectrum disorder;informal support;informant;innovation;Intervention;Interview;Job Satisfaction;Knowledge;Life;life time cost;Longitudinal Studies;Measures;Mental Health;Methods;National Longitudinal Survey of Youth;Neurodevelopmental Disorder;novel;Occupations;Parents;Phenotype;Positioning Attribute;Predictive Factor;Productivity;professional atmosphere;programs;prospective;Psychopathology;Public Health;Quality of life;Questionnaires;recruit;Research;response;Sample Size;Sampling;Secondary Schools;Services;Severities;sex;Social support;Societies;Specificity;Strategic Planning;success;Testing;therapy development;Time;Transcript;Translating;Vocation;Wages;Work;young adult;young adult with autism spectrum disorder

PROJECT_TITLE: A Longitudinal Study of Employment and Educational Instability for Young Adults with Autism Spectrum Disorder

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Dementia;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Huntington's disease (HD) is an inherited disorder that causes neurons to die in the brain, leading to motor dysfunction and cognitive impairment. The goal of this grant is to identify novel modulators of a specific potassium ion channel to help mitigate the toxicity in HD.

PI_NAMEs: SCHLESSINGER, AVNER ;SLESINGER, PAUL A (contact)

PROJECT_TERMS: Address;Affinity;Alcohols;Amino Acids;Antipsychotic Agents;Astrocytes;Attention;Basal Ganglia;Biological Assay;Brain;CAG repeat;Cell Physiology;Cell-Free System;Cells;Cessation of life;Chorea;Coculture Techniques;cognitive function;Collaborations;Corpus striatum structure;Delusions;Dementia;disease model;Electrophysiology (science);Evaluation;Excision;experimental study;extracellular;Foundations;Glutamates;Goals;Grant;Hallucinations;Hereditary Disease;Homeostasis;Huntington Disease;Huntington gene;Impaired cognition;Impairment;improved;In Vitro;in vivo;Inherited;inhibitor;innovation;inward rectifier potassium channel;Life Expectancy;Ligands;Liposomes;motor behavior;motor disorder;motor impairment;Movement;Mus;mutant;Mutation;National Center for Advancing Translational Sciences;Nerve Degeneration;Neurodegenerative Disorders;neuronal circuitry;neuronal excitability;Neurons;neurotransmission;novel;overexpression;Pathology;pharmacophore;Play;polyglutamine;Porifera;Potassium;Potassium Channel;Procedures;protein reconstitution;Research Personnel;Role;screening;sensor;Site;small molecule;Structural Models;success;Synapses;Testing;Tetrabenazine;Toxic effect;Transfection;Up-Regulation;uptake;virtual screening

PROJECT_TITLE: Identifying New Astrocytic Kir4.1 Channel Modulators for Treating Huntington's Disease


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: CHARLESTON

ORG_DEPT: DENTISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Tetracycline antibiotics (i.e., minocycline, doxycycline) are a common systemic treatment for acne during adolescence, a critical developmental phase during which the skeleton accrues substantial bone mass. Tetracyclines’ effects on gut microbes and adolescent skeletal maturation are unclear. The proposed research will discern how tetracyclines modify gut bacteria to affect skeletal maturation, bone health, and fracture risk.

PI_NAMEs: WESTWATER, CAROLINE  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Accounting;Acne;Adolescence;Adolescent;Affect;Age;Agonist;Animals;antagonist;Antibiotics;Attenuated;Bacteria;bacteriome;Bile Acid Biosynthesis Pathway;Bile Acids;bile salts;bone;bone cell;bone health;bone mass;bone metabolism;C57BL/6 Mouse;Cell Physiology;Circulation;clinically relevant;critical developmental period;CYP7A1 gene;Development;Distant;Dose;Doxycycline;dysbiosis;Endocrine;Enterocytes;Euthanasia;Excretory function;fecal microbiota;fexaramine;FGFR4 gene;Fibroblast Growth Factor;Fracture;fracture risk;germ free condition;Germ-Free;gut bacteria;gut dysbiosis;gut microbes;gut microbiota;Hepatic;Hepatocyte;High Prevalence;Homeostasis;Hydrolase;Impairment;In Situ;in vivo;Indigenous;inhibitor;Intestines;Knockout Mice;Life;Liver;mechanical properties;Mediating;Metagenomics;microbiota;Minocycline;Mus;novel;Osteoblasts;osteoclastogenesis;Osteogenesis;Osteopenia;Osteoporosis;Phase;Phenotype;Production;Puberty;Publishing;Reporting;Research;Resistance;Role;Serum;Signal Transduction;Site;skeletal;skeletal maturation;Skeleton;Tamoxifen;Testing;Tetracyclines;Work

PROJECT_TITLE: Impact of Tetracycline Antibiotics on Skeletal Maturation

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Pediatric;Precision Medicine;Social Determinants of Health;Transplantation

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE The goal of this application is to improve the durability of pediatric medical devices made of implantable biomaterials thus reducing the need for multiple cardiac re-operations in children. Our lab discovered that the permanent incorporation of circulating proteins via glycation can impair the structure of the biomaterials and favor the absorption of calcium-binding proteins. Since glycation and calcification precursors are overexpressed in children, we believe that our strategies to mitigate protein absorption will be particularly efficient in pediatric patients.

PI_NAMEs: FERRARI, GIOVANNI  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: absorption;Acceleration;Adolescent;Adult;Age;Allografting;Animal Model;aortic valve;Architecture;Autologous;Automobile Driving;base;Biochemistry;Biocompatible Materials;Biological Assay;Biomechanics;Bioprosthesis device;bioscaffold;Blood;calcification;Calcium;calcium absorption;Calcium-Binding Proteins;Cardiac;cardiac device;Cardiac Surgery procedures;Cattle;Cellular Infiltration;Chemistry;Child;Childhood;Clinical;Collagen;crosslink;Crosslinker;Cryopreservation;Data;Deposition;Development;Device or Instrument Development;Devices;Disease;Disparity;extend lifespan;Failure;Glutaral;glycation;Goals;Grant;Growth and Development function;Heart Valves;Impairment;Implant;implant material;implantable device;improved;In Vitro;in vivo;in vivo evaluation;Inflammatory Response;innovation;juvenile animal;Literature;Mechanics;Medical Device;Methodology;Mission;Mitral Valve;Modeling;Myocardial Degeneration;National Heart, Lung, and Blood Institute;Operative Surgical Procedures;Outcome;overexpression;oxidation;Patients;pediatric patients;Performance;pericardial sac;Physiologic pulse;Polymers;precision medicine;Preclinical Testing;Predisposition;programs;protein protein interaction;Proteins;Proteomics;Publishing;pulmonary valve replacement;Rattus;Reconstructive Surgical Procedures;Repeat Surgery;Role;Series;Serum Proteins;Sheep;Sprague-Dawley Rats;Statutes and Laws;Structure;subcutaneous;System;Testing;Thick;Translating;Underserved Population;United States National Institutes of Health;uptake;Work;Xenograft procedure;young adult

PROJECT_TITLE: Mechanisms of accelerated calcification and structural degeneration of implantable biomaterials in pediatric cardiac surgery

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Machine Learning and Artificial Intelligence;Orphan Drug;Patient Safety;Precision Medicine;Rare Diseases;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Chronic graft-versus-host disease (cGVHD) is the leading cause of morbidity and non-relapse mortality in survivors of allogeneic transplantation. Our understanding of the biologic abnormalities associated with different clinical phenotypes is lacking, preventing our ability to rationally choose cGVHD treatments. The proposed studies will bring together clinical, laboratory and statistical collaborators to address these knowledge gaps.

PI_NAMEs: LEE, STEPHANIE J (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Affect;Allogenic;Autoimmune Diseases;B-Lymphocytes;biobank;Biological;biomarker identification;Cells;Characteristics;chemokine;chronic graft versus host disease;Clinical;Clinical Data;clinical phenotype;clinically relevant;cohort;Collaborations;Complication;Consensus;Cryopreservation;cytokine;Data;Data Scientist;Dendritic Cells;Disease Management;disorder subtype;early detection biomarkers;Endothelial Cells;Enrollment;Fibroblasts;financial toxicity;Flow Cytometry;Functional disorder;Funding;Goals;Hematologic Neoplasms;Hematological Disease;Hematopoietic Stem Cell Transplantation;Homologous Transplantation;Human;Iatrogenesis;Immunosuppression;Immunosuppressive Agents;improved outcome;individual patient;Knowledge;Laboratories;Laboratory Markers;Lichen Planus;Life;Logistic Regressions;Machine Learning;Macrophage;Morbidity - disease rate;mortality;novel;Observational Study;Organ;Outcome;Outcome Assessment;Participant;Pathway interactions;patient subsets;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;personalized medicine;phenotypic data;Plasma;Plasma Proteins;Population;predicting response;Prediction of Response to Therapy;prevent;prospective;prospective test;Proteins;Quality of life;Refractory Disease;Reporting;response;response biomarker;Sampling;side effect;Sjogren's Syndrome;statistical learning;Steroids;success;survival prediction;Survivors;Symptom Burden;Syndrome;Systemic disease;Systemic Lupus Erythematosus;Systemic Scleroderma;T-Lymphocyte;Techniques;Testing;Therapeutic;Therapeutic Studies;therapeutic target;Time;translational scientist;transplant survivor;Transplantation;treatment duration;treatment response;United States National Institutes of Health;unsupervised learning;Validation;Work

PROJECT_TITLE: Improving Outcomes Assessment in Chronic Graft versus Host Disease

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE: Primary hyperparathyroidism is caused by a parathyroid single adenoma in almost 90% of cases and is usually cured surgically. Although preoperative localization such as sestamibi SPECT/CT and intraoperative PTH blood tests have greatly improved surgical therapy of primary hyperparathyroidism in patients, there is still no capability for real-time, intraoperative navigation to localize parathyroid glands during surgery. Furthermore, it is imperative that surgeons identify and preserve normal parathyroid glands during thyroid surgery to avoid postoperative hypocalcemia, where invisible near-infrared fluorescent light can provide sensitive and specific guidance during surgery, but only if optimal contrast agents are available.

PI_NAMEs: BOUVET, MICHAEL ;CHOI, HAK SOO  (contact);HENARY, MAGED M

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: absorption;Acute;Address;adenoma;Adipose tissue;Adrenal Glands;Adverse effects;Affinity;Animal Model;Animals;Area;Award;Binding;Biological Availability;Blood Tests;Carcinoma;Cells;cellular targeting;Chemicals;Chemistry;Clinical;Clinical Research;clinical translation;Contrast Media;curative treatments;Data;Detection;Development;Dose;Down-Regulation;Drug or chemical Tissue Distribution;Endocrine;Endocrine Glands;Evaluation;Excretory function;Family suidae;Feces;Fluorescence;fluorophore;Formulation;Funding;Future;Goals;Grant;halogenation;Halogens;Histologic;Hormones;Human;Hyperparathyroidism;Hyperplasia;Hypocalcemia;Image;image guided;image-guided drug delivery;Image-Guided Surgery;imaging modality;imaging system;Imaging Techniques;improved;Injections;intravenous injection;Islet Cell Tumor;Kinetics;Lead;Light;Location;lymph nodes;Mediating;Medicine;Mitochondria;molecular imaging;Molecular Target;Morbidity - disease rate;Multi-Drug Resistance;Mus;National Institute of Biomedical Imaging and Bioengineering;Nature;Neck;Normal tissue morphology;novel;Operative Surgical Procedures;Pancreas;pancreatic neoplasm;Parathyroid Adenoma;Parathyroid gland;Parathyroidectomy;Patients;Performance;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;phenoxazine;Pituitary Gland;Postoperative Period;preservation;Procedures;Rattus;real-time images;resistance gene;Safety;safety study;scale up;Sensitivity and Specificity;Series;single photon emission computed tomography;Structure;subcellular targeting;Surgeon;Technology;Testing;Therapeutic Intervention;Thymus Gland;Thyroid Gland;Thyroidectomy;Time;Tissues;Toxic effect;tumor;United States National Institutes of Health;uptake;Urine;Validation;Visualization;whole body imaging

PROJECT_TITLE: Targeting parathyroid glands with novel fluorophores for intraoperative imaging

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Health Services;Mental Health;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse;Women's Health Research

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Multiple approaches have been investigated to reduce the substantial care and cost burden of treating infants with neonatal opioid withdrawal syndrome (NOWS) postnatally, including through dyadic approaches such as the Eat, Sleep, Console (ESC) protocol that encourages mothers to instinctively care for their newborns during the birth hospitalization. Far less attention has been paid to understanding the clinical needs and subsequent trajectory of care for infants with NOWS during the remainder of their first year of life—including the risks and costs of hospital readmissions and how best to support mothers with OUD in keeping their infants safe during a time when both mother and child are especially vulnerable. This proposal addresses the challenges and costs of caring for infants with NOWS once they leave the hospital and are in the care of their parents, social workers, and community healthcare providers with two studies that shift the focus from the immediate post-partum period to the first year of life.

PI_NAMEs: GAITHER, JULIE ROZELLE (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Accidental Injury;active method;Address;Adolescent;Adult;Affect;Area;Attention;Autonomic nervous system;Award;Birth;care costs;career;career development;Caring;Central Nervous System;Child;Child Abuse;Clinical;clinical care;Community Healthcare;cost;cost effective;design;Development;Diagnosis;Disease;Eating;economic evaluation;Epidemiologist;evidence base;Evidence based intervention;Family;Female of child bearing age;gastrointestinal;Goals;Health Care Costs;health data;Health Personnel;Healthcare;Helping to End Addiction Long-term;high risk;high risk infant;Home;Home visitation;Hospital Costs;hospital readmission;Hospitalization;Hospitals;illicit opioid;implementation science;improved outcome;infancy;Infant;Infant Care;infant outcome;Injury;intersectionality;Intervention;Interview;Knowledge;large datasets;Length of Stay;Life;Lived experience;maltreatment;Maternal complication;maternal opioid use;maternal stress;Medical;medical schools;Mentorship;Mission;Modeling;Monitor;Mothers;National Institute of Child Health and Human Development;neglect;Neonatal Abstinence Syndrome;Newborn Infant;Opioid;opioid epidemic;opioid use disorder;Overdose;Parents;Pediatric Hospitals;Pediatric Nursing;Personal Satisfaction;postnatal;Postpartum Period;prescription opioid;prevent;Protocols documentation;Qualitative Research;Recovery;relapse risk;Research;Research Methodology;Resources;Risk;Safety;secondary analysis;Site;skills;Sleep;Social Workers;Stress;Structure;substance use;Substance Use Disorder;Time;Training;United States National Institutes of Health;Work

PROJECT_TITLE: The Clinical Challenges and Costs of Caring for Infants with Neonatal Opioid Withdrawal Syndrome (NOWS) in the Post-Nursery Period

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project narrative: mRNA 3’ processing is an essential step in eukaryotic gene expression and alternative polyadenylation is an important mechanism for gene regulation. In this proposal, we will characterize the structure-function relationship of the mRNA 3’ processing complex and the mechanisms by which RNA-binding proteins and post-translational modifications of the core mRNA 3’ processing factors regulate alternative polyadenylation.

PI_NAMEs: SHI, YONGSHENG  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Biochemical;Complex;Development;Disease;Gene Expression;Gene Expression Regulation;Genes;Genomics;Goals;insight;Malignant Neoplasms;Messenger RNA;mRNA Stability;Nervous System Disorder;novel;novel therapeutics;Pattern;Play;Polyadenylation;Post-Transcriptional Regulation;Post-Translational Protein Processing;programs;Protein Isoforms;Regulation;Research;RNA metabolism;RNA-Binding Proteins;Role;Signal Transduction;Structure-Activity Relationship;Translations

PROJECT_TITLE: Mechanisms and regulation of mRNA 3' processing

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Prostate cancer is the most commonly diagnosed non-skin cancer in men, and the second most common cause of cancer death for men: it is a high-incidence, high-fatality, high-morbidity and high- cost cancer that is growing increasingly frequent in our aging population. We hypothesize that the clinical and molecular evolution of localized prostate cancers are shaped by germline genomic features and present strong preliminary data to support this concept. This proposal with quantify the contribution of germline to prostate cancer evolution through TWAS, ancestry studies and large cohort generalization studies.

PI_NAMEs: BOUTROS, PAUL CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: African ancestry;Age;Aggressive behavior;aging population;American;Asian ancestry;Asian population;Autopsy;biobank;Bioinformatics;Biological Markers;Biopsy;BRCA2 Mutation;cancer diagnosis;Cancer Etiology;Castration;Cessation of life;Clinical;clinical risk;cohort;cost;Data;Data Set;Diagnosis;digital;Disease;Disease Resistance;Distant;DNA Repair;DNA sequencing;European ancestry;Evolution;follow-up;gene repair;Genes;Genetic;Genetic Polymorphism;Genome;Genomics;Germ Lines;Germ-Line Mutation;Heritability;Hispanic ancestry;Hispanic Populations;Incidence;Individual;Indolent;lifetime risk;Link;Local Therapy;male health;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Care Costs;men;Methods;Molecular;Molecular Evolution;Monitor;Morbidity - disease rate;Newly Diagnosed;novel;Odds Ratio;Pathway Analysis;Pathway interactions;Patients;polygenic risk score;Population;Population Heterogeneity;Prostate;Prostate-Specific Antigen;Prostatic Neoplasms;Publishing;Rectum;repository;Risk;risk prediction;risk stratification;Sample Size;Serum;serum PSA;Shapes;Site;Skin Cancer;Solid;Somatic Mutation;standard of care;Stratification;Testing;TMPRSS2 gene;transcriptome;tumor;tumor diagnosis;United States;Variant;whole genome

PROJECT_TITLE: Germline Determinants of Prostate Cancer Evolution

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Clinical Research;Health Services

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: This training grant brings together a successful and expert group of dedicated research investigators who will combine their efforts at a renowned university to train outstanding and promising surgical residents to develop new treatments to enhance healing and to determine the successful delivery of surgical care. Our aim is to address the fundamental need to train American surgical investigators to develop the skills in translational scientific inquiry and to learn and apply the key principles of health services research in order to foster the discovery of new therapies to treat patients with wounds as well as congenital and acquired deformities and to determine the efficacy of those treatments.

PI_NAMEs: BUCHMAN, STEVEN R (contact);CHUNG, KEVIN C

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: Grant;Health Services Research;Operative Surgical Procedures;Scientist;Training;Translational Research

PROJECT_TITLE: Surgical Scientist Training Grant in Health Services and Translational Research


NIH_SPENDING_CATS: Clinical Research;Diabetes;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative People with or being evaluated for the diagnosis of diabetes and their providers usually take for granted that their hemoglobin A1c (HbA1c) result faithfully reflects their blood sugar control because the amount of sugar on hemoglobin is determined by how much sugar it has been exposed to over its life time. However, new devices that can routinely measure blood sugar continuously for weeks with low cost and convenience confirm that in as great as 1 out of 3 people there is a significant mismatch between HbA1c and the blood sugar directly measured by the devices. Therefore, the purpose of this proposal is to demonstrate that these mismatches are primarily due to variation in the lifespan of the red blood cell, the cell in the blood in which Hemoglobin is located; this will personalize HbA1c allowing it to complement the new devices and be a better measure of blood sugar control improving the care of millions of people with diabetes.

PI_NAMEs: COHEN, ROBERT MAYNARD (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Abnormal Cell;African American;Age;Black Populations;Blood;Blood Glucose;Blood specimen;Caring;Caucasians;cell age;Cell Volumes;Cells;Clinical;clinically relevant;clinically significant;Collaborations;Complement;Complete Blood Count;Complex;Complication;Complications of Diabetes Mellitus;Continuous Glucose Monitor;cost;cost effective;Data;Devices;diabetes management;Diabetes Mellitus;Diagnosis;Equation;Erythrocytes;Evaluation;Event;Exposure to;foot;Future;Glucose;glucose monitor;glycemic control;Glycosylated hemoglobin A;Hemoglobin;Hemoglobinopathies;Heterogeneity;Hypoglycemia;improved;Individual;individual patient;Life;life span;Link;Measurement;Measures;Methods;Modeling;Modernization;Monitor;monitoring device;Patients;personalized diagnostics;Persons;Population;Prevalence;prevent;prospective;Protocols documentation;Provider;Race;racial difference;recruit;Reproducibility;Research;Research Technics;Reticulocytes;Risk;risk prediction;Role;Solid;Spottings;stable isotope;standard measure;sugar;Techniques;Testing;Time;Translations;Variant;Work

PROJECT_TITLE: Towards optimizing diabetes management and diagnosis by personalizing HbA1c targets

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE In order to survive, organisms need to respond and adapt to stress signals from the environment. Our work focuses on both a general stress response, which confers broad cross-protection to multiple stressors, and specific stress responses elicited by DNA damage. Both of these stress responses have relevance for molecular evolution and the development of novel antibiotics.

PI_NAMEs: DEACONESCU, ALEXANDRA M. (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Address;Affect;Age;Antibiotics;antimicrobial;Antimicrobial Resistance;Area;Bacteria sigma factor KatF protein;biological adaptation to stress;Biology;Catalysis;Collaborations;Collection;Combination Drug Therapy;Coupled;Coupling;COVID-19 pandemic;cross immunity;Development;Dissection;DNA;DNA Damage;DNA Repair;DNA-Directed RNA Polymerase;Environment;Evolution;Genetic Transcription;Genomics;Infection;Lesion;Mediating;Modality;Molecular Evolution;Mutagenesis;Nature;novel;Nucleotide Excision Repair;Organism;pathogen;Pathway interactions;Process;programs;promoter;Proteins;Proteolysis;Public Health;Reagent;recruit;Regulation;repaired;Research;response;Signal Transduction;SOS Response;Specificity;Stress;stressor;Structural Biochemistry;structural biology;Transcription Elongation;Transcription Initiation;Transcription-Coupled Repair;transmission process;Work

PROJECT_TITLE: MECHANISMS AND MACROMOLECULAR INTERACTIONS UNDERLYING CELLULAR RESPONSES TO STRESS SIGNALS

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: MADISON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative It is critically important to promote interest and motivation for underrepresented minority and first-generation students in introductory biology and chemistry courses, which act as a gateway to successive courses and biomedical careers. Increasing the pool of talent for doctorates in the biomedical sciences is crucial, for these are the persons who will pioneer essential advances to improve the health of the U.S. population. I propose a set of large-scale, multi-institutional field experiments, with long-term follow-up of students, to test a utility-value intervention intended to help promote motivation and performance for underrepresented minority and first-generation students in biology and chemistry classes.

PI_NAMEs: HARACKIEWICZ, JUDITH M. (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Achievement;Back;Baltimore;Biology;broadening participation research;career;Chemistry;college;Communities;Control Groups;County;Course Content;Cultural Backgrounds;Data;Double-Blind Method;Education;Ethnic Origin;experimental study;First Generation College Students;Funding;gateway course;Generations;Goals;Health;improved;Institution;interest;Intervention;intervention effect;learning materials;Long-Term Effects;Longterm Follow-up;Maryland;minority student;Motivation;Parents;Performance;Persons;Population;programs;racial diversity;Randomized;Research;Sampling;Science;Site;Societies;socioeconomics;Students;Talents;Testing;Time;Underrepresented Minority;Universities;Wisconsin;Writing

PROJECT_TITLE: Broadening Participation in the Biomedical Sciences with Utility Value Interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: MEMPHIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Glaucoma is the leading cause of irreversible blindness in the world, which is projected to affect ~6.3 million Americans by 2050, and intraocular pressure (IOP) is a leading contributor to glaucoma. The project addresses the major limitations of current glaucoma therapy by advancing a sustained-release IOP- lowering formulation that coordinates multiple targets to normalize IOP, and possibly protect retinal ganglion cells. Minimum performance metrics for the novel formulation will position researchers to move toward clinical trials and eventually to commercialization.

PI_NAMEs: JABLONSKI, MONICA M (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Advanced Development;Affect;American;Aqueous Humor;aqueous humor flow;Biodistribution;biomaterial compatibility;Blindness;Calcium Channel;Cell Death;Cessation of life;Characteristics;chemical synthesis;Ciliary Body;Clinical Trials;commercialization;Cornea;Data;Development;Disease;Dose;Drainage procedure;Drops;Drug Compounding;Drug Delivery Systems;Drug Kinetics;Drug Targeting;Drug usage;Emulsions;endophenotype;Engineering;Exhibits;experience;experimental study;Eye;Eyedrops;Formulation;Genes;Genetic;genetic approach;Glaucoma;Goals;Haplotypes;high intraocular pressure;Hour;Human;Hyperemia;Incidence;individualized medicine;inhibitor;innovation;Investigational New Drug Application;Link;Macaca;Marketing;Measurement;Measures;Movement;Mus;nerve damage;neuroprotection;new therapeutic target;novel;novel therapeutics;Optic Nerve;Oryctolagus cuniculus;Outcome;Pathway interactions;Patient Compliance;Patients;Penetration;Performance;personalized approach;Persons;Pharmaceutical Preparations;Pharmacodynamics;Phase;Physiologic Intraocular Pressure;Positioning Attribute;precision medicine;pregabalin;Preparation;Primary Open Angle Glaucoma;Production;Proteins;R24;Research;Research Personnel;residence;response;retinal axon;Retinal Ganglion Cells;Risk Factors;side effect;small molecule;small molecule inhibitor;standard of care;Time;Topical application;Trabecular meshwork structure;treatment strategy;United States;Visual;Visual Fields

PROJECT_TITLE: Novel Extended Release Glaucoma Therapy for Once Daily Dosing


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: We are in the midst of a growing epidemic of obesity, insulin resistance and type 2 diabetes. There are few sustainable prevention strategies and not enough fully effective treatments for these serious disorders. Major gaps exist in our knowledge of the molecular mechanisms underlying insulin resistance and type 2 diabetes, limiting our ability to develop highly effective and safe therapies. Attention has focused on understanding the problems with glucose or lipid metabolism separately but the mechanistic links between these pathways are poorly understood. We recently discovered a new class of lipids that have beneficial metabolic and anti-inflammatory effects. The levels of these lipids are low in people who are at risk for, or have, type 2 diabetes. Studies in this proposal will determine how levels of these beneficial lipids are regulated in normal physiologic states and in obesity and diabetes. Understanding the mechanisms regulating these lipids could provide new insights into the pathogenesis of type 2 diabetes and new treatment strategies.

PI_NAMEs: KAHN, BARBARA B. (contact);SAGHATELIAN, ALAN

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Adipose tissue;Anabolism;Anti-diabetic Drugs;Anti-Inflammatory Agents;Antiinflammatory Effect;Attention;Autoimmune;Binding Proteins;Biochemical Pathway;Biological Assay;Biology;Biopsy;blood glucose regulation;candidate identification;Carbohydrates;Clinical;clinically relevant;cofactor;Colitis;Data;Diabetes Mellitus;Diglycerides;Disease;diverse data;effective therapy;Enzymes;Esters;experimental study;Family;Family member;Fasting;fatty acid biosynthesis;fatty acid metabolism;Fatty Acids;feeding;Functional disorder;Funding;Gene Expression Regulation;Genes;Genetic;genetic approach;Genetic Models;Genetic Variation;Glucose;glucose metabolism;glucose production;glucose tolerance;glucose transport;Health;Hepatic;High Fat Diet;Human;human tissue;Hydrolase;Hydrolysis;hydroxy fatty acid;Immune;improved;in vivo;Inbred Strains Mice;Incidence;inhibitor;innovation;insight;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;islet;Isomerism;Isotope Labeling;Isotopes;Knock-out;Knockout Mice;Knowledge;Link;Lipase;lipid metabolism;Lipids;Lipolysis;Liver;Measurement;Measures;Mediating;Metabolic;Metabolic stress;Mild obesity;Molecular;mouse model;Mus;Muscle;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obesity;Obesity Epidemic;overexpression;Palmitic Acids;Pathogenesis;Pathway interactions;Persons;Phenotype;Phospholipase;Physiological;Physiological Adaptation;Plasma;Population;Positioning Attribute;prevent;Prevention strategy;protein expression;Proteins;Regulation;Regulator Genes;Regulatory Pathway;response;Response Elements;Risk;Role;Serum;Severities;Stable Isotope Labeling;Stearic Acids;subcutaneous;System;Systems Analysis;Testing;Tissues;Transacylase;transcriptome;transcriptomics;Transferase;translational potential;Triglycerides;United States National Institutes of Health

PROJECT_TITLE: Mechanisms for regulation of a novel class of anti-diabetic lipids

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Social Determinants of Health

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: Project Narrative: This NEI Short-Term Institutional Training Grant renewal application requests 5 years of support for 8 rising second year Medical Student trainees in our Vision Science laboratories for a 10 week research experience. We will focus on recruitment of under-represented trainees into this program to enhance the diversity of our medical workforce. The T35 training grant will be used to entice our medical students into our Distinction in Research Track, a program that encourages students to participate in laboratory research in years 2-4 of medical school with an eye toward scholarly activities in academic medicine to continue to build a pipeline of translational clinician-researchers.

PI_NAMEs: CERESA, BRIAN P. (contact);MCCALL, MAUREEN A

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: animal care;Authorship;Basic Science;Biology;career;Clinical;Clinical Research;Conflict of Interest;corneal epithelium;Data;design;disadvantaged background;drug discovery;Education;Environment;ethnic minority;experience;fabrication;Faculty;Female;Foundations;Funding;Goals;Homeostasis;Hour;human subject;Institutional Review Boards;Interview;Laboratories;Laboratory Research;medical schools;Medical Students;Mentors;Mentorship;Ophthalmology;peer;Physicians;Plagiarism;posters;Productivity;programs;Publications;Research;Research Personnel;Research Project Grants;Research Training;responsible research conduct;Retinal Degeneration;Science;Scientist;Series;skills;Structure;Student recruitment;Students;Systems Development;Time;Training;Training Programs;Translational Research;Universities;Uveitis;Vision;vision development;Vision research;vision science;Visual;Work

PROJECT_TITLE: Summer Vision Sciences Training Program


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: The proposed research will develop a magnetic resonance imaging method called quantitative susceptibility mapping (QSM) for the characterization and risk evaluation of unstable carotid atherosclerotic plaque that can cause ischemic stroke. A successful outcome of this research will provide a reliable noninvasive imaging tool for stroke prevention and research on vascular diseases.

PI_NAMEs: GUPTA, AJAY ;KAMEL, HOOMAN ;NGUYEN, THANH D (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: age related changes;Algorithms;Area;Arterial Fatty Streak;Blood;Blood Vessels;calcification;Carotid Artery Plaques;Carotid Endarterectomy;Carotid Stenosis;Carotid stent;cell injury;Cephalic;Clinical;clinical imaging;clinical risk;Contrast Media;Data;Detection;Development;Diagnosis;diagnostic accuracy;Discrimination;efficacy evaluation;Embolism;Erythrocytes;Evaluation;ex vivo imaging;experience;Extravasation;Fingerprint;Hemoglobin;Hemorrhage;Hemosiderin;high risk;Histology;Histopathology;Image;image reconstruction;Imaging Device;imaging modality;improved;in vivo imaging;Individual;Inflammation;Ipsilateral;Iron;Ischemic Stroke;Lead;Magnetic Resonance Imaging;Magnetism;Maps;Measures;Medical;Methemoglobin;Motion;Noise;non-invasive imaging;novel strategies;Outcome;Outcomes Research;Oxidative Stress;patient stratification;Patients;personalized medicine;Phase;Physiologic pulse;Predisposition;Property;Protocols documentation;reconstruction;Reproducibility;Research;revascularization;Risk;Risk Factors;risk prediction;risk stratification;ROC Curve;Rupture;Sampling;Scanning;Schedule;secondary outcome;Signal Induction;Stenosis;Stroke;Stroke prevention;stroke risk;superparamagnetism;Testing;thromboembolic stroke;Thrombus;Time;Tissues;Vascular Diseases;X-Ray Computed Tomography

PROJECT_TITLE: Quantitative Susceptibility Mapping for Stroke Risk Prediction of Vulnerable Carotid Plaques

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Infertility;Polycystic Ovary Syndrome (PCOS);Prevention;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative This meeting grant proposes support for the Annual and Update meetings of the Androgen Excess-PCOS Society. The goals are to promote knowledge and original clinical and basic research, in every aspect of androgen excess, improving the understanding, diagnosis, treatment, and prevention of these disorders.

PI_NAMEs: DOKRAS, ANUJA  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Acanthosis Nigricans;Acne;Address;Adrenal Glands;adrenal hyperplasia;Advisory Committees;Affect;Aging;American;androgen excess;Androgens;Anxiety Disorders;Area;Award;Awareness;Basic Science;Blood Vessels;Cardiovascular Diseases;Caring;Child Care;Childhood;Clinical;clinical application;clinical care;Clinical Research;Clinical Trials Design;Collaborations;college;Communities;Critiques;Dedications;Defect;Detection;Development;Diabetes Mellitus;diabetogenic;Diagnosis;Discipline;Discipline of obstetrics;Disease;disorder prevention;Dyslipidemias;Education;Embryology;Endocrine;Endometrial Carcinoma;Epidemiologist;Epidemiology;Ethnic Origin;Etiology;European;Evaluation;Female;Fostering;Future;General Population;Genetic;Genotype;Goals;Grant;Guidelines;Gynecologic;Gynecology;Health;Hirsutism;Human;Hyperandrogenism;Hypertension;improved;Infertility;Insulin;Insulin Resistance;interest;Internal Medicine;International;Investigation;Knowledge;lectures;Location;Male Pattern Baldness;Medical;medical complication;meeting abstracts;meetings;Menopause;Metabolic;Metabolic syndrome;Molecular;Mood Disorders;Morbidity - disease rate;multidisciplinary;Neoplasms;Neurosecretory Systems;next generation;Non-Insulin-Dependent Diabetes Mellitus;Nutritionist;obesity risk;Oral;Organizational Objectives;Ovarian;Participant;Patient Education;patient engagement;Patients;Pharmaceutical Preparations;Phenotype;Physicians;Polycystic Ovary Syndrome;Population;Positioning Attribute;posters;premature adrenarche;Prevention;Printing;Professional Organizations;professor;Prognosis;programs;Psychologist;psychosocial;Publications;Quality of life;Race;Reporting;Reproduction;reproductive;Reproductive Endocrinology;Reproductive Medicine;Request for Applications;Research;Research Personnel;Risk Factors;Scientist;Senior Scientist;Sleep Apnea Syndromes;Societies;Support Groups;Surveys;symposium;Syndrome;Translating;Travel;treatment strategy;Underrepresented Minority;Update;Woman;Work

PROJECT_TITLE: Androgen Excess Polycystic Ovary Syndrome Society Meeting

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: SEASIDE

ORG_NAME: CALIFORNIA STATE UNIV,  MONTEREY BAY

PHR: PROJECT NARRATIVE Working parents of children with mental health disabilities (MHD) experience chronic stress linked to unique contextual factors that lead them to not disclose their child's health status because of fear of discrimination, retaliation and job loss. Uncertainty regarding the outcome of disclosure can create decisional conflict regarding whether, when, what, and how much to disclose of their child's MHD to employers when seeking workplace support to manage disability-related care demands, which in turn contributes to increased risk of stress related illnesses. Activities proposed in this project seek to mitigate decisional conflict and reduce stress related to disclosing their child's health status at work by developing and testing a web-based decision aid providing structured feedback on whether, what and when to disclose their disability-related care demands to their supervisor based on knowledge of risks, benefits and priority-setting activities that provides individualized feedback on disclosure preferences, and resources supporting the highest ranked priority.

PI_NAMEs: STEWART, LISA MAUREEN (contact)

PROJECT_TITLE: My Choice: Developing a Workplace Disclosure Decision Aid and Resources for Working Parents of Children with Mental Health Disabilities

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


NIH_SPENDING_CATS: Genetics

ORG_CITY: PITTSBURGH

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Liquid-phase separated biomolecular condensates spatially organize RNA regulation into p- bodies and stress granules in eukaryotes. Here we investigate if simple bacteria cells that lack organelles, exploit liquid phase separation to organize and regulate mRNA decay in a manner similar to p-bodies and stress granules. We anticipate these studies will reveal new broad layers of bacterial gene regulation that impact cellular processes such as virulence and could be targeted for antibiotic development.

PI_NAMEs: CHILDERS, WILLIAM SETH (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Alphaproteobacteria;Antibiotics;Bacteria;Bacterial Genes;Behavior;Binding;Biochemical Pathway;Biochemistry;Biological Assay;Brucella abortus;C-terminal;Cattle;Caulobacter crescentus;Cell division;Cell Physiology;Cells;Chronic Granulomatous Disease;Collaborations;Crowding;Cytoplasmic Granules;Data;Development;Disease;enzyme activity;enzyme pathway;Eukaryota;Exhibits;Exonuclease;experimental study;fitness;Gene Expression Regulation;Genetic;Goals;In Vitro;in vivo;inhibitor;insight;Knowledge;Learning;Life;Lipids;Liquid substance;Mammalian Cell;Membrane;Messenger RNA;mRNA Decay;mRNA Transcript Degradation;Organelles;pathogen;Pathogenesis;Pathway interactions;Peptidoglycan;Permeability;Phase;Physical condensation;Physiological;Physiological Processes;Plants;Process;Proteins;Reagent;Regulation;Rhizobium radiobacter;ribonuclease E;Ribonucleases;Ribonucleoproteins;RNA;RNA Decay;RNA Degradation;Role;scaffold;self assembly;Sodium Chloride;Stress;stress granule;Structure;success;Testing;Untranslated RNA;Virulence;Work

PROJECT_TITLE: Biomolecular condensates as organizers of mRNA decay in bacteria

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: CK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Public Relevance Statement. The Emory/PEACH epicenter will leverage national experts across diverse scientific disciplines at Emory University, Georgia Tech, and several other partnering institutions to inform and implement the scientific program of the CDC’s Prevention Epicenter, whose mission is to reduce antibiotic resistant infections across the spectrum of healthcare delivery. Clinical research proposed to occur in Atlanta includes in depth studies to find better ways to contain and eliminate the spread of superbugs aimed to have an impact across the region.

PI_NAMEs: JACOB, JESSE THOMAS (contact)

PROJECT_TITLE: RFA-CK-20-004: Prevention Epicenter of Emory and Collaborating Healthcare Facilities (PEACH II)


NIH_SPENDING_CATS: Cardiovascular;Kidney Disease

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The studies in this application propose to continue recent advances made in the causes of heart, vascular and bone problems produced by kidney diseases. The laboratory of the applicant has identified new causes of these heart problems and a possible new treatment. The studies proposed in the application will help bring the new treatment into trials of a new drug for kidney diseases and their complications.

PI_NAMEs: HRUSKA, KEITH A (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: activin A;Activin A type II receptor;Activin Receptor;Activins;Address;Affect;Aorta;Binding;Blood Vessels;bone;Bone Diseases;Bone Formation Stimulation;Bone Resorption;calcification;Calcitriol;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cell Wall;Cells;Chronic Kidney Failure;Circulation;Clinical Trials;Complication;Death Rate;Disease;disease mechanisms study;disease model;effective intervention;Family;Family member;FGFR4 gene;fibroblast growth factor 23;Functional disorder;General Population;Goals;Heart;Heart Diseases;Heart Hypertrophy;Hyperparathyroidism;improved outcome;inhibitor;Injury to Kidney;inorganic phosphate;Investigation;Kidney;Kidney Diseases;kidney fibrosis;kidney repair;knock-down;Laboratories;Lead;Ligands;member;Mesenchymal Stem Cells;Minerals;Modeling;Monoclonal Antibodies;Morbidity - disease rate;mortality;mortality risk;Names;Nephrons;novel;novel therapeutics;Organ;osteoblast differentiation;Osteoblasts;Osteocytes;pandemic disease;Pathogenesis;prevent;Process;Production;Quality of life;receptor;Regulation;release factor;Renal Osteodystrophy;repaired;Reporting;Research;restoration;Risk;Risk Factors;Role;Signal Transduction;skeletal;Skeleton;Syndrome;Systemic disease;Testing;Therapeutic;therapeutic target;Tissues;TNFSF11 gene;transcription factor;transcriptome;Transforming Growth Factor beta;Type II Activin Receptors;Validation;Vascular calcification;Vascular Diseases;Vitamin D Analog;Work

PROJECT_TITLE: Novel Advances in the Pathophysiology and Treatment of the CKD-MBD


NIH_SPENDING_CATS: Nutrition

PHR: Lay Summary This proposal will provide an intensive, educational, and mentored-research summer experience to build and enhance the diversity of the biomedical, behavioral, clinical, and social science research workforce in NIDDK mission areas.

PI_NAMEs: ARBELAEZ, ANA MARIA ;REEDS, DOMINIC N (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: 18 year old;Admission activity;Area;Award;Behavioral Sciences;career;career development;Childhood;Climate;Clinical;Clinical Research;Clinical Sciences;cohort;Collaborations;Communities;Country;Creativeness;cultural competence;Decision Making;Development;Development Plans;Diabetes Mellitus;disabled;Disadvantaged minority;Disease;diversity and inclusion;Education;education research;Eligibility Determination;Epidemiology;Evaluation;evidence base;experience;Faculty;faculty mentor;Feedback;follow-up;Functional disorder;Generations;graduate school;Graduation Rates;Health;Health Professional;Hour;improved;Individual;Infrastructure;innovation;insight;Institution;Investigation;Leadership;medical schools;Medicine;member;Mentors;Mentorship;Methods;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Neurosciences;nutrition;Obesity;Outcome Assessment;Participant;peer coaching;Physicians;professional students;programs;recruit;Research;Research Design;Research Training;Resources;Role;Scholarship;Schools;Science;Scientist;skill acquisition;skills;social science research;Structure;Students;success;summer program;summer research;support network;symposium;Technical Expertise;Time;Training;Training and Infrastructure;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;Universities;university student;Washington;webinar

PROJECT_TITLE: Summer Program for the Advancement of Research Relevant to NIDDK (SPARK)


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative Fewer than half of all children with high-risk neuroblastoma become long-term survivors. The goal of this project is to develop biomarkers to improve risk stratification at diagnosis, biomarkers of minimal residual disease for early therapy intervention, and the identification of gene networks which drive high-risk neuroblastoma. This work will have a transformative impact by identifying new ways to diagnose and monitor neuroblastoma using liquid biopsies, potentially enabling early introduction of novel therapeutics.

PI_NAMEs: APPLEBAUM, MARK ANDREW (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Automobile Driving;Biological;Biological Markers;Biology;biomarker validation;Biopsy;Blood specimen;burden of illness;cancer cell;cancer type;candidate identification;cell free DNA;chemotherapy;Child;Clinical;Clinical assessments;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Copy Number Polymorphism;Cytosine;Data;Deposition;Detection of Minimal Residual Disease;Diagnosis;Diagnostic;diagnostic biomarker;Disease;Disease Resistance;Disparate;DNA;DNA Markers;Early Diagnosis;Early Intervention;Early treatment;Elasticity;Enrollment;Epigenetic Process;gene network;Genes;Genetic Transcription;Goals;Growth;high risk;high risk population;improved;improved outcome;In Vitro;invention;Knock-out;liquid biopsy;Long-Term Survivors;machine learning method;Malignant Neoplasms;MAP Kinase Gene;Methodology;Methods;Methylation;Modification;Monitor;Mutation;nano;Neoadjuvant Therapy;Neuroblastoma;Newly Diagnosed;North America;novel;novel therapeutics;participant enrollment;Patient-Focused Outcomes;Patients;Pediatric Oncology Group;peripheral blood;phase 3 study;predictive marker;Primary Neoplasm;profiles in patients;Prognosis;prognostic;prognostic assays;prognostication;prospective;Recurrence;Recurrent disease;Refractory Disease;Relapse;relapse prediction;relapse risk;research clinical testing;Residual Neoplasm;response;response biomarker;Retrospective cohort;Risk;risk stratification;Sampling;screening;seal;Specificity;success;Therapeutic;Therapeutic Intervention;therapy resistant;Training;treatment response;tumor;tumor DNA;Tumor Suppressor Proteins;Validation;whole genome;Work

PROJECT_TITLE: Liquid biopsy approaches to inform neuroblastoma prognosis and disease monitoring

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Pediatric;Social Determinants of Health

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: Project Narrative This project will create a coordinating center to deliver mentoring and research experiences in STEM for high school students from groups historically excluded in the sciences (e.g., ethnic and gender minorities, rural students, economically disadvantaged) across Department of Health & Human Services Region A. Mentors from across the region will be trained and equipped by the Cold Spring Harbor Laboratory DNA Learning Center to bring advanced genomics into a summer research and school year mentoring program. Ultimately, a sustainable network of mentors and students will create new, inclusive opportunities that diversify the nation’s STEM workforce.

PI_NAMEs: WILLIAMS, JASON  (contact)

PROJECT_TERMS: Active Learning;African American student;Algebra;Area;Biochemical;Bioinformatics;Biology;Biotechnology;Black American;Black race;Cities;cohort;college;College Preparation;cost effective;curriculum development;Data Science;Disparity;Distance Learning;DNA;DNA laboratory;Doctor of Philosophy;economic disparity;Educational process of instructing;elementary school;Enrollment;Equipment;Equity;ethnic minority;Ethnic Origin;Exclusion;experience;Exposure to;Faculty;faculty support;Feedback;Foundations;Gender;gender minority;Generations;Genetic;Genomics;Gifts;Goals;Graduation Rates;high school;High School Student;Hispanic Americans;Household;Income;Infrastructure;Institution;Instruction;junior high school;Laboratories;Latin American;Latino;Latino Population;Learning;member;Mentors;Methods;Minority;Minority-Serving Institution;Mission;Modernization;Native Americans;New York City;Outcome;outreach;Participant;pedagogy;Play;Population;Probability;programs;project-based learning;recruit;Research;Research Support;Resources;Rural;Schools;Science;skills;Societies;STEM career;Students;summer research;symposium;Talents;teacher;Teacher Professional Development;Techniques;tenure track;Texas;Time;Training;undergraduate research experience;undergraduate student;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;Urban Population;Work

PROJECT_TITLE: Genomics STEP-UP High School Coordinating Center Region A; Increasing Diversity Through Genomics Research Experiences


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Kidney Disease;Precision Medicine

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed work aims to elucidate the role of clonal hematopoiesis of indeterminate potential (CHIP) in the progression of kidney disease and development of cardiovascular disease (CVD) in chronic kidney disease (CKD) patients. Knowledge gained from this study may contribute novel insights into the biological pathways underlying common CKD sequelae and help to identify CKD patients at high risk for kidney failure and CVD.

PI_NAMEs: KELLY, TANIKA NICOLE (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: age related;age-related disease;Aging;aging related;Articulation;Atherosclerosis;biobank;Biological;Biological Markers;Blood Cells;Blood Pressure;Blood Vessels;Cardiac;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular health;CDKN2A gene;Chronic;Chronic Kidney Failure;Chronic Kidney Insufficiency;Clinical;Clonal Expansion;cohort;Cohort Studies;Cox Proportional Hazards Models;Data;Development;Dialysis procedure;differential expression;Disease Progression;DNA Sequence Alteration;End stage renal failure;Event;exome sequencing;Fibrosis;follow-up;Follow-Up Studies;Gene Expression;Genes;Genetic;genomic data;hazard;Heart Injuries;Hematopoiesis;High Prevalence;high risk;human old age (65+);improved;Inflammation;Inflammatory;inhibitor;Injury;Injury to Kidney;insight;interest;Journals;Kidney Diseases;Kidney Failure;Kidney Transplantation;Knowledge;Linear Regressions;Link;Lipids;longitudinal analysis;Measurement;Measures;Mediating;Medicine;Meta-Analysis;Modeling;Molecular;molecular marker;Myocardial Infarction;Myocardial Ischemia;nephrogenesis;New England;novel;older adult;Outcome;Participant;Pathway interactions;Patients;personalized strategies;Phase;Phenotype;Precision Health;premature;prevent;programs;prospective test;Public Health;Publications;recruit;Recurrence;Renal function;Renin-Angiotensin-Aldosterone System;Research;Resources;Risk Factors;risk stratification;Role;Sample Size;Somatic Mutation;Stress;stroke event;Structural Models;Testing;Time;trait;Trans-Omics for Precision Medicine;transcriptome sequencing;Variant;Work;young adult

PROJECT_TITLE: Clonal Hematopoiesis of Indeterminate Potential in Chronic Kidney Disease Patients

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, with 607 followed at University of Maryland Baltimore (UMB), to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: CHANG, LINDA ;ERNST, THOMAS M (contact)

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Baltimore;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Maryland;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;Universities;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 2/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UMB


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE The proposed research will examine recently discovered RNA modifications and molecular mechanisms that govern the lifetime of messenger RNA in bacterial cells. The knowledge thereby acquired is expected to be of value in understanding the regulatory processes that control bacterial pathogenesis and antibiotic sensitivity. Because of their broad applicability, the concepts and methods developed in the course of these studies have the potential to accelerate progress toward elucidating the mechanisms by which messenger RNA degradation impacts not only microbial infection but also human cell physiology.

PI_NAMEs: BELASCO, JOEL G (contact)

PROJECT_TERMS: Acceleration;Antibiotics;Bacteria;Bacterial RNA;Biochemical;Biological;Biophysics;Cell Physiology;Cells;Diffusion;endonuclease;Environment;Gene Expression;Gene Expression Regulation;Genetic;Goals;Human;Infection;insight;Knowledge;Messenger RNA;Methods;microbial;Modification;Molecular;mRNA capping;mRNA Transcript Degradation;novel;Organism;Pathogenesis;Phylogenetic Analysis;Play;Process;Research;Research Project Grants;ribonuclease E;RNA;RNA Degradation;Scanning;Site;Stress;Transcript

PROJECT_TITLE: Mechanisms of bacterial RNA degradation


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Narrative Inflammation is central to the initiation and progression of heart failure, a leading cause of death and hospitalizations worldwide. Results from this proposal will provide ground for the identification of inflammatory mechanisms in HF with preserved ejection fraction, a type of HF with no treatments available.

PI_NAMEs: ALCAIDE ALONSO, MARIA PILAR  (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: activating transcription factor 1;Affect;antagonist;anti-cancer;Antibodies;Antigens;ATF6 gene;biological adaptation to stress;Biological Availability;Cardiac;Cardiac Myocytes;cardiometabolism;Cause of Death;CD4 Positive T Lymphocytes;Cell Separation;Cells;Cellular biology;Clinical;comorbidity;Complex;coping;cytokine;Data;Dependence;Development;Disease;Down-Regulation;effector T cell;EFRAC;Elements;endoplasmic reticulum stress;epidemiology study;Esters;Experimental Models;feeding;Fostering;Functional disorder;gain of function;Gene Expression Profile;Genes;Goals;Heart;Heart failure;heart failure with reduced ejection fraction;High Fat Diet;Hospitalization;Human;Hypertension;Hypertrophy;Immune;Immune response;immunomodulatory strategy;immunoregulation;Impairment;improved;Infiltration;Inflammation;Inflammatory;insight;loss of function;Mediating;Metabolic stress;Metabolic syndrome;Modeling;Molecular;mouse model;Mus;Myocardial;Myocardial tissue;Myocardium;NG-Nitroarginine Methyl Ester;Nitric Oxide;Nitroarginine;nitrosative stress;novel;Obesity;Organelles;Outcome;overexpression;Pathway interactions;Patients;Phenotype;Pre-Clinical Model;preservation;Process;programs;protein folding;Proteins;Relaxation;response;Response Elements;Rodent Model;Role;sensor;Stress;Syndrome;T cell infiltration;T cell regulation;T cell response;T-cell inflamed;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Transcript;transcriptome sequencing;Transgenic Mice;tumor;Tumor Immunity;valsartan;Wild Type Mouse

PROJECT_TITLE: Regulation of T cell immune response in Heart Failure with Preserved Ejection Fraction

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Nutrition;Obesity

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: The prevention and treatment of obesity, diabetes, and kidney disease are high priorities for researchers, clinicians, and members of the public. The overall goal of the Wake Forest School of Medicine STEP-UP training grant is to provide an integrated career development undergraduate training program in the skills and competencies needed to conduct rigorous and impactful research in preparation for graduate research education. Through research mentorship, educational seminars, research experiences, and professional skills training, trainees will emerge well-prepared to apply to graduate schools and succeed in graduate programs.

PI_NAMEs: GWATHMEY, TANYA M.;MOORE, JUSTIN BRIAN (contact)

PROJECT_TERMS: 2,4-Dinitrophenol;Address;Admission activity;Area;Awareness;Behavioral;Behavioral Research;Behavioral Sciences;Blood Vessels;career;career development;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communities;comorbidity;Competence;Creativeness;Dedications;Degree program;design;Diabetes Mellitus;Doctor of Philosophy;Education;education research;Elements;Enrollment;Epidemiologist;Exercise;experience;Exposure to;Extramural Activities;Faculty;follow-up;Goals;Graduate Degree;graduate school;Grant;hands on research;Health Disparities Research;health disparity;High School Student;Hypertension;insight;Institution;Interdisciplinary Study;interest;Internships;Interview;Kidney Diseases;Knowledge;medical schools;meetings;member;Mentors;Mentorship;Metabolism;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;NIH Program Announcements;notch protein;nutrition;Obesity;Obesity associated kidney disease;obesity treatment;Online Systems;Participant;Peer Review;Physicians;Population;Population Heterogeneity;Positioning Attribute;Preparation;Prevention;Productivity;programs;Publications;Recording of previous events;recruit;Recruitment Activity;Research;Research Personnel;Resource Development;Resources;Science;Scientist;senior faculty;Site;skill acquisition;skills;skills training;Socialization;success;Technical Expertise;Training;Training Programs;undergraduate student;Underrepresented Students;Universities;webinar;Writing

PROJECT_TITLE: Wake Forest School of Medicine Short-Term Research Experience Program to Unlock Potential