ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Data Science;HIV/AIDS;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative The overall goal of the proposed research is to integrate individual-level data from eight state agencies and county-level data from multiple open data sources and develop a prediction model for multiple viral load indicators through AI-based modeling, accounting for factors at the individual level, structural level, and socioenvironmental level among people living with HIV (PLWH) in South Carolina. The results will enable the identification of PLWH with poor viral control and further inform healthcare providers of “when” and “how” to help those PLWH achieve and maintain viral suppression. The proposed research will improve our understanding of the longitudinal dynamics of viral suppression and inform effective HIV control strategies towards the goal of ending the HIV epidemic in the US.

PI_NAMEs: OLATOSI, BANKOLE  (contact);ZHANG, JIAJIA

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Accounting;Address;alcohol and other drug;Alcohol consumption;antiretroviral therapy;Area;artificial intelligence model;Big Data;Binding;Caring;Centers for Disease Control and Prevention (U.S.);Clinical;cohort;comorbidity;Complex;County;Data;Data Sources;Databases;demographics;design;Diagnosis;Drug usage;economic indicator;Economics;Electronic Health Record;Epidemic;Epidemiology;experience;Failure;follow-up;Geographic Locations;Goals;Health care facility;health care service utilization;Health Personnel;Health Professional;Health system;HIV;HIV diagnosis;HIV Infections;hospital care;immune function;improved;Individual;Knowledge;Laboratories;Link;Literature;Managed Care;Measures;Medical Records;medical specialties;Modeling;mortality;national surveillance;open data;Outcome;Patients;Pattern;Persons;Phase;pilot test;Population;predictive modeling;prisma;Regimen;Research;restoration;Risk;risk prediction model;Rural;Sampling;Services;social;Social Environment;socioeconomics;South Carolina;substance use;success;surveillance data;Surveys;System;therapy adherence;Time;tool;Translating;transmission process;Treatment Protocols;treatment response;United States;United States National Institutes of Health;uptake;Viral;Viral Load result;viral rebound;Viremia;Visit

PROJECT_TITLE: Patterns and predictors of viral suppression: A Big Data approach


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PI_NAMEs: BARBE, MARY F (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acceleration;Address;adipokines;Adipose tissue;Aerobic Exercise;Affect;Aging;Anti-Inflammatory Agents;antifibrotic treatment;Axon;axon regeneration;Behavior;Biological;biopsychosocial factor;Body System;bone;Cell Communication;Chronic;chronic painful condition;Complex;connective tissue growth factor;Cumulative Trauma Disorders;cytokine;design;Diagnosis;Down-Regulation;Early treatment;Encapsulated;Event;Exercise;Exertion;Failure;Female;Fibrosis;Functional disorder;functional improvement;improvement on sleep;Inflammaging;Inflammation;Inflammatory;inflammatory milieu;Injury;insight;Intervention;Investigation;Link;male;Modeling;Mononeuropathies;Motor;Muscle;Muscle Fibers;musculoskeletal injury;Musculoskeletal Pain;Nerve;nerve injury;Neuromuscular Junction;neuromusculoskeletal;Neuropathy;Nociceptors;Nonpharmacologic Therapy;novel;Occupational;osteoclastogenesis;Outcome;Pain;pain behavior;pain chronification;Pain intensity;pain reduction;pain relief;Pathologic Processes;Pathway interactions;Patients;Persons;pharmacologic;Physical activity;physically handicapped;poor sleep;Positioning Attribute;prevent;Prevention;Preventive treatment;Rattus;Recovery;repaired;response;Role;sex;Sleep;Sleep Deprivation;Sleep disturbances;Stimulus;Structure;success;systemic inflammatory response;Tendinopathy;Tendon structure;Testing;Thinking;Time;tissue biomarkers;Tissues;young adult

PROJECT_TITLE: Biomarkers of Tissue Tolerance and Behavior in a Rat Model

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BIRMINGHAM

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative The UAB-HudsonAlpha Genomic Medicine Training Program seeks to train the next generation of MDs, PhDs, and PharmDs to be leaders in the integration of genomics into medical practice. The core of the program is mentored research in genomic medicine at UAB and at HudsonAlpha. A rich set of educational offerings, as well as experiences in clinics and clinical laboratories, public outreach and education, and entrepreneurship are tailored to the individual needs of each trainee.

PI_NAMEs: BARSH, GREGORY STEFAN;LIMDI, NITA A (contact)

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TERMS: Genomic medicine;Training Programs


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Gene Therapy;Genetics;Mucopolysaccharidoses (MPS);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: Chicago

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative Lysosomal storage diseases (>40 different diseases) are often fatal in pediatric subjects. They are caused by a specific protein deficiency that breaks down waste products within the cell. For several of these diseases, gene therapy clinical trials are ongoing or about to start, but there is no way to track their therapeutic efficacy. We have developed a series of MRI based contrast agents that are able to non-invasively track the therapeutic protein. In this proposal, we will perform the necessary experiments to translate to patients.

PI_NAMEs: ESTEVES, MIGUEL S;GRAY-EDWARDS, HEATHER L;MARTIN, DOUGLAS R;MEADE, THOMAS J (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;Aftercare;Alpha-glucosidase;Animal Model;Architecture;Beta-glucuronidase;beta-n-acetylhexosaminidase;Biodistribution;Biological Markers;Brain;Candidate Disease Gene;Capsid;Cells;Central Nervous System;chemical synthesis;Chemicals;Childhood;Clinical;clinical development;contrast enhanced;Contrast Media;Darkness;Data;Dependovirus;design;Detection;Development;Diagnostic radiologic examination;Disease;Disease Progression;Dose;Enzymes;Evolution;experimental study;Felis catus;G(M2) Ganglioside;Galactosamine;Galactose;Galanin;Ganglioside GM1;Gangliosidoses GM2;Gangliosidosis GM1;Gene Expression;gene therapy;gene therapy clinical trial;Gene Transfer;gene-targeted therapy;Genes;Genotype;GLB1 gene;Glycogen storage disease type II;Hemophilia A;Histologic;Human;imaging agent;in vivo;Incidence;Infant;Injections;Intravenous;Investigational Drugs;Ionizing radiation;Ions;large scale production;Libraries;Lipids;Liver;Lysosomal Storage Diseases;Magnetic Resonance Imaging;Magnetism;manufacture;Measures;Mediating;Medicine;Methods;Modality;Modification;mouse model;Mucopolysaccharidosis VII;Mus;Mutation;Nervous System Disorder;Organ;Oxidation-Reduction;Patients;Peripheral Nervous System;Phenotype;Preclinical Testing;Prevalence;prevent;Procedures;Production;Prognosis;Property;Protein Deficiency;Proteins;Rattus;Recycling;Research Personnel;Safety;Sandhoff Disease;scale up;Series;Slice;Spinal Muscular Atrophy;Structure;sugar;Survival Rate;Techniques;Technology;technology validation;Testing;Thalamic structure;therapeutic enzyme;therapeutic protein;Three-Dimensional Imaging;Time;Tissues;Toxic effect;Translating;translation to humans;translational applications;Translations;Treatment Efficacy;Waste Products;Water

PROJECT_TITLE: Real-Time Tracking of Gene Therapy by Bioactivated MR contrast Probes


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Hepatoblastoma (HB) is the most common liver cancer in children with a survival rate of <50% in patients with high-risk disease, especially those with vascular invasion (VI). Unfortunately, HB with VI patients receive aggressive therapies that are toxic and ineffective; therefore, a better understanding of the biomarkers and biology of VI in HB is urgently needed. In the current study, we propose to study the protein expression of HB cells that invade the blood vessels to create prediction models and targeted treatments for patients with high- risk HB.

PI_NAMEs: ESPINOZA, ANDY  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Address;Adjuvant Therapy;aggressive therapy;Area;Basement membrane;Biological Assay;Biological Markers;Biology;biomarker panel;biomarker signature;Biopsy;Biopsy Specimen;Blood;Blood Vessels;cancer cell;Cancer Center;career;cell growth;Cell Line;Cells;Cellular Structures;chemotherapy;Child;Cisplatin;Clinical;Clinical Trials;cohort;Data;design;Development;Diagnostic;Disease;disorder risk;drug development;Drug Targeting;effective therapy;Epithelium;Exhibits;experimental study;fetal;Formalin;Foundations;Freezing;Future;gain of function;Gene Expression;Gene Expression Profile;Genes;genetic signature;Growth;Hepatic;Hepatoblastoma;high risk;Histologic;Histopathology;IL6 gene;imaging study;Immunohistochemistry;improved;improved outcome;In Vitro;in vivo;inhibitor;innovation;International;Invaded;Knowledge;knowledge translation;Laboratories;Liver neoplasms;loss of function;Malignant Childhood Neoplasm;Malignant neoplasm of liver;Matrix Metalloproteinases;Measures;Mesenchymal;migration;Molecular;mouse model;multiplexed imaging;Neoplasm Metastasis;neoplastic cell;novel;novel marker;Operative Surgical Procedures;Outcome;Paraffin Embedding;Pathway interactions;patient derived xenograft model;patient stratification;Patient-Focused Outcomes;Patients;Phenotype;pre-clinical;Pre-Clinical Model;preclinical study;predictive modeling;predictive signature;prevent;Primary Neoplasm;protein expression;Proteins;Registries;Relapse;Reporting;Research;Research Technics;Risk;risk prediction;risk stratification;Role;Sampling;Scientist;Signal Transduction;specific biomarkers;Specimen;standard of care;Standardization;STAT3 gene;Stromal Cells;Surgeon;Survival Rate;targeted treatment;Technology Assessment;Testing;therapeutic target;Thrombus;Tissues;tool;transcriptome sequencing;Treatment Protocols;tumor;Tumor Cell Invasion;Validation;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Defining Protein Signature of Vascular Invasion in Hepatoblastoma


NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The choroid plexus (ChP) produces and delivers important health- and growth-promoting factors to the  , developing brain. We will use cutting-edge methods for monitoring and manipulating calcium activity in ChP epithelial cells in explants and in vivo to test whether ChP epithelial cell calcium activity increases in response to local and maternally derived stimuli and thereby regulates brain development via regulation in ChP gene transcription and protein secretion into the cerebrospinal fluid (CSF). These experiments represent a critical new direction of investigation into how local embryonic and maternal-fetal environments interact with the ChP to dynamically regulate brain development.

PI_NAMEs: LEHTINEN, MARIA  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Affect;Agonist;Apical;Axon;Bathing;Brain;Brain Stem;brain tissue;Calcium;Cells;Cerebral cortex;Cerebrospinal Fluid;Choroid Plexus Epithelium;Couples;Cues;Data;Development;Diffusion;direct application;Embryo;Embryonic Development;Environment;Epithelial Cells;Epithelium;experimental study;fetal;Fetal health;Future;G-Protein-Coupled Receptors;Gene Expression;gene induction;Gene Proteins;Genetic;Genetic Transcription;Growth;Health;Image;Immediate-Early Genes;In Vitro;in vivo;in vivo calcium imaging;intraperitoneal;Intraperitoneal Injections;Investigation;Ligands;loss of function;Mediating;Methods;Modernization;Molecular;Monitor;Mus;Nature;nerve stem cell;Neurodevelopmental Disorder;Neurologic;Neurons;neurosteroids;novel;Penetrance;Peripheral;Phenotype;Placenta;postnatal;Process;Production;Protein Secretion;receptor;Receptor Activation;Receptor Signaling;Regulation;response;Salivary Glands;Serotonin;Signal Pathway;Signal Transduction;Source;stem cell niche;Stimulus;Structure of choroid plexus;Surface;Testing;tool;transcriptome;transcriptome sequencing;transcriptomics;vesicular release

PROJECT_TITLE: Activity-dependent Regulation of the Choroid Plexus-Cerebrospinal Fluid Stem Cell Niche

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Faithful replication of cellular DNA is of the highest importance in maintaining the integrity of genetic information. Often, replication goes wrong because of the presence of DNA damage or other problems, leading to the activation of several DNA damage response pathways. Patients with known defects in these pathways are at a greatly increased risk for developing cancer. These processes are highly conserved from human to baker's yeast, and therefore, studies in this biochemically and genetically approachable model organism are highly relevant to understanding the analogous processes in humans.

PI_NAMEs: BURGERS, PETER M (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;ATR gene;Biochemical;biophysical analysis;Bypass;Cell Cycle Checkpoint;Cells;Complex;Coupling;Cryoelectron Microscopy;Defect;DNA;DNA biosynthesis;DNA Damage;DNA lesion;DNA Maintenance;DNA metabolism;DNA replication fork;DNA-Directed DNA Polymerase;Environment;Eukaryota;Eukaryotic Cell;Event;fascinate;Functional disorder;genetic analysis;genetic information;Genetic study;Human;insight;Investigation;Lesion;Malignant Neoplasms;model organism;Mutagenesis;Okazaki fragments;Orthologous Gene;Pathway interactions;Patients;Process;Protein Kinase;Regulation;Replication Origin;response;Risk;Saccharomyces cerevisiae;sensor;System;TEL1 Gene;Yeasts

PROJECT_TITLE: Mechanisms of DNA replication and maintenance in eukaryotes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Infectious Diseases;Lung;Organ Transplantation;Pediatric;Prevention;Rare Diseases;Transplantation

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Lung transplant extends the lives of patients with advanced lung disease, but long-term survival is limited by development of chronic lung allograft dysfunction (CLAD). To reduce CLAD and improve lung transplant outcomes, including both survival and quality of life, we propose a clinical trial testing a novel drug that prevents inflammatory cytokine signaling with complementary mechanistic studies to determine treatment effects on innate and adaptive immune responses.

PI_NAMEs: BELPERIO, JOHN A;PALMER, SCOTT M (contact);SWEET, STUART C

PROGRAM_OFFICER_NAME: HAYES, DEBORAH

PROJECT_TERMS: Acute;Acute Lung Injury;adaptive immune response;Address;Adult;Affect;Allografting;Bilateral;Biology;Biopsy;Bone Marrow Transplantation;Bronchiolitis;Child;Childhood;Chronic;Clinic;clinical efficacy;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Network;Communicable Diseases;cytokine;Cytokine Receptors;Cytokine Signaling;Cytomegalovirus;Cytomegalovirus Infections;Data;Data Collection;design;Development;Diagnosis;double-blind placebo controlled trial;effective therapy;Electronics;Enrollment;experience;Family;Feasibility Studies;follow-up;Functional disorder;Graft Rejection;graft vs host disease;high risk;Human;Immune;immune activation;Immune response;Immunity;Immunosuppression;improved;Individual;Inflammation;Inflammatory;Inflammatory Response Pathway;inhibitor;Innate Immune Response;JAK1 gene;JAK2 gene;JAK3 gene;Janus kinase;Leadership;Liquid substance;Lung;lung allograft;Lung Diseases;Lung Transplantation;Lymphocyte;Measures;Mediating;member;Mission;Morbidity - disease rate;mortality;Multicenter Studies;Mus;Natural Immunity;North America;novel;novel strategies;novel therapeutics;Organ Transplantation;Outcome;Outcome Measure;overexpression;participant enrollment;Pathology;Patient Outcomes Assessments;Patients;Pediatric Hospitals;Pennsylvania;Placebos;Pneumonia;post-transplant;prevent;Prevention;primary outcome;programs;Prophylactic treatment;prospective;Pulmonary Inflammation;Qualifying;Quality of life;Randomized;randomized, clinical trials;Research;Research Design;Research Personnel;Risk;Risk Factors;risk sharing;Safety;Science;Signal Transduction;Site;Solid;Source;Structure;Structure of parenchyma of lung;T-Lymphocyte;Testing;Tissues;transplant model;Transplant Recipients;Transplantation;Transplantation Immunology;treatment effect;TYK2;Universities;Up-Regulation;Viral;Washington;Work

PROJECT_TITLE: Lung Transplant Clinical Trial Network (LT-CTN)


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Our ability to finely control gene expression and chromatin state over time at specific genomic loci and genome- wide has improved vastly in the last decades due to the development of programmable DNA binding domains, but it is currently limited by the availability of potent, compact, and versatile effector domains that can be easily delivered, multiplexed, and act efficiently in different genomic and chromatin contexts. To fill this gap and create a comprehensive resource defining the functional effector domains that regulate gene transcription, we will use a high-throughput platform that we have recently developed to systematically test thousands of putative transcriptional and chromatin effector domains from human transcription factors, viral proteins, and nanobody libraries for their effects on gene activation, repression, and epigenetic memory. Characterization of these effectors in terms of their interaction partners, associated chromatin modifications, and effects at different types of endogenous loci will allow us to develop a novel and extensive toolbox for reliable transcriptional and chromatin perturbations.

PI_NAMEs: BASSIK, MICHAEL C;BINTU, LACRAMIOARA  (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Binding;Biological;Biological Assay;Catalogs;cell type;Cells;Chromatin;chromatin modification;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cofactor;Complex;CRISPR interference;CRISPR-mediated transcriptional activation;Data Set;Development;Disease;DNA Binding Domain;DNA Maintenance;DNA Modification Process;DNA Sequence Alteration;DNA-Binding Proteins;Elements;Engineering;Enhancers;epigenetic memory;Epigenetic Process;epigenetic silencing;epigenome;epigenomics;Exhibits;experimental study;Future;Gene Activation;Gene Expression;Gene Silencing;gene therapy;Genes;Genetic;genetic manipulation;Genetic Screening;Genetic Transcription;Genome;genome-wide;genomic locus;Genomics;high throughput screening;histone modification;Human;human disease;Human Genome;improved;interest;Knock-out;Label;Learning;Libraries;Maintenance;Maps;Measures;Memory;Methyltransferase;Molecular;Molecular Profiling;nanobodies;novel;Pathway interactions;promoter;Property;Proteins;recruit;Regulator Genes;Regulatory Element;Reporter;Reporter Genes;Repressed Memory;Resources;screening;synthetic protein;System;Technology;Tertiary Protein Structure;Testing;Time;tool;transcription factor;Transcriptional Activation;Untranslated RNA;Viral;Viral Proteins;Work;Yeasts

PROJECT_TITLE: High-throughput development and characterization of compact tools for transcriptional and chromatin perturbations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-B(50)R]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: BOZEMAN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: PROJECT NARRATIVE Staphylcoccus aureus (S. aureus) is a leading cause of morbidity and mortality worldwide. One of the most clinically significant aspects of S. aureus infections is the high prevalence of drug resistance and the innate ability for S. aureus to develop resistance to antibiotics making it very difficult to develop therapeutics that will have potential for long-term efficacy against S. aureus. Given the diminishing effectiveness of our current antibiotics, it is clear we must improve our understanding of molecular mechanisms fundamental to S. aureus pathogenesis in order to develop better methods to control/treat S. aureus disease and, thus, improve public health.

PI_NAMEs: NYGAARD, TYLER K;VOYICH, JOVANKA M (contact);WILSON, ERIC

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Antibiotic Resistance;Antibiotics;antimicrobial;Apoptosis;Autophagocytosis;Bacterial Genes;Bacterial Infections;Cell Communication;Cell Culture System;Cell Culture Techniques;Cells;clinically significant;combat;Communities;community setting;Cytolysis;Data;design;Development;Disease;Drug resistance;Effectiveness;emerging pathogen;Environment;Event;experimental study;extracellular;Foundations;Functional disorder;Future;Gene Expression;Genes;Genetic Transcription;High Prevalence;Hospitals;Human;Immune;Immune response;Immunotherapeutic agent;improved;in vivo;Individual;Infection;Inflammation Mediators;leukotoxin;Life;Link;Mediating;Methods;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Natural Immunity;Necrotizing fasciitis;neutrophil;Neutrophil Infiltration;next generation sequencing;novel;novel therapeutics;novel vaccines;Outcome;Outpatients;pathogen;Pathogenesis;Pathway interactions;Peripheral Blood Mononuclear Cell;Peroxidases;Phagocytosis;Play;Population;prevent;Production;Public Health;Publishing;Reactive Oxygen Species;Regulation;Reporting;Research;Resistance development;response;Risk;RNA;Role;sensory system;Sepsis;Severities;Signal Transduction;Skin;skin abscess;Soft Tissue Infections;Staphylococcus aureus;Staphylococcus aureus infection;System;Testing;Therapeutic;Time;TNF gene;Transcript;transcriptome;transcriptome sequencing;Up-Regulation;Vaccines;Virulence;virulence gene;Visit

PROJECT_TITLE: Defining SaeR/S-dependent Neutrophil-S. aureus Interactions that Determine the Outcome of Infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infertility;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Polycystic Ovary Syndrome (PCOS);Pregnancy;Prevention;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Inadvertent fetal exposure to excess steroids or steroid mimics poses risks to reproductive and metabolic health in humans. Using a novel animal model and dietary interventions, the proposed studies will identify neural, ovarian and metabolic mechanisms by which fetal exposure to excess steroids and postnatal obesity lead to fertility problems in first- and second-generation female offspring. Moreover, these studies aim to identify lifestyle intervention strategies to not only ameliorate the pathology but, more importantly, to prevent transfer of disease traits to subsequent generations.

PI_NAMEs: CARDOSO, RODOLFO C.;PADMANABHAN, VASANTHA  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Adult;Adverse event;Animal Model;Animals;Anovulation;Barker Hypothesis;Biological;Body System;Breeding;Cell Physiology;Clinical;Defect;Deterioration;Development;Dietary Intervention;dietary restriction;Disease;disease transmission;Environment;Environmental Risk Factor;Epigenetic Process;Evaluation;excessive weight gain;Exhibits;Exposure to;Failure;Feedback;feeding;Female;Fertility;fertility improvement;fetal;Fetus;Functional disorder;Generations;Genetic Transcription;Goals;Health;Hormonal;Human;Hyperandrogenism;Impairment;improved;Incidence;Infertility;Insulin Resistance;Intervention;intervention effect;Investigation;Lead;Life Style Modification;lifestyle intervention;meetings;Metabolic;Metabolic dysfunction;metabolic phenotype;Mission;Modeling;Molecular;Morphology;Mothers;neural;Neurosecretory Systems;next generation;novel;Nutritional;Obesity;offspring;oligo anovulation;Oligonucleotides;Outcome;Ovarian;ovarian dysfunction;Partner in relationship;Pathologic;Pathology;Phenotype;Polycystic Ovary Syndrome;postnatal;Pregnancy;premature;prenatal;prenatal exposure;prevent;Preventive;Process;public health relevance;reduce symptoms;Reproduction;reproductive;reproductive axis;reproductive development;reproductive senescence;Research;Resources;Risk;Severities;Sheep;sheep model;Steroids;System;Testing;Testosterone;Therapeutic;tool;trait;translational model;transmission process;United States National Institutes of Health;Vertical Disease Transmission;Vertical Transmission;Virilism;Weight Gain;Woman

PROJECT_TITLE: Multigenerational Effects of Gestational Testosterone Excess

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: TEMPE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: This application addresses several important central issues that have broad application in the areas of virus-host interactions, innate immunity, cellular transformation, and viral oncolysis of cancer cells. The proposed studies will demonstrate the role of key and potent viral modulator of cellular factors of the RNA helicase superfamily that mediate expanded cellular tropism, particularly in human cells, how two key viral host range factors modulation of multiple signaling pathways benefit the virus replication and expand the cellular tropism of the virus and their potential oncolysis of cancer cells. The model virus proposed here is Myxoma virus (MYXV), which infects only rabbits in nature, but has significant potential for the treatment of multiple human cancers and the findings can be applicable for other oncolytic viruses as well.

PI_NAMEs: RAHMAN, MASMUDUR MOHAMMED (contact)

PROGRAM_OFFICER_NAME: KNISELY, JANE M

PROJECT_TERMS: Address;Affect;anti-cancer;Area;Binding;cancer cell;Cancer Model;cancer therapy;Cancerous;cell growth;cell killing;Cell Nucleus;cell transformation;Cells;Cellular Tropism;Cytoplasm;Cytoplasmic Granules;Data;delivery vehicle;Development;Double-Stranded RNA;Exhibits;Exportins;Family;FDA approved;Gene Delivery;Gene Expression;Genes;Goals;Human;Immune;In Vitro;in vivo;inhibitor;Innate Immune Response;Interferons;knock-down;Lagomorpha;Leporipoxvirus;Malignant Neoplasms;Mediating;member;metaplastic cell transformation;Modeling;Molecular;multiple myeloma M Protein;Mus;Myxoma virus;Natural Immunity;Nature;novel virus;Nuclear;Nuclear Export;oncolysis;Oncolytic;oncolytic virotherapy;Oncolytic viruses;Oryctolagus cuniculus;Pathway interactions;permissiveness;Pharmaceutical Preparations;Poxviridae;Protein Family;Proteins;Reporting;RNA Helicase;Role;Signal Pathway;Signal Transduction;Somatic Cell;Testing;Tissues;Tropism;vaccine platform;Vaccines;Viral;Viral Physiology;viral RNA;Virus;virus host interaction;Virus Replication;virus tropism;Work;Xenograft procedure

PROJECT_TITLE: Studies in Poxvirus Host Range Genes and Tropism

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: RICHARDSON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: PROJECT NARRATIVE  The University of Texas at Dallas (UTD) has significant potential to capitalize on its status as one of “most diverse” campuses in the US along with its robust STEM programming to successfully launch and sustain the MARC at UTD program. By developing the MARC at UTD program, underrepresented minority students, low income and first-generation students, and students with disabilities can be offered carefully tailored opportunities to participate in biomedical research and be prepared to compete and succeed in graduate studies.

PI_NAMEs: BURTON, MICHAEL D (contact);KOLBER, BENEDICT J

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TITLE: MARC Program at the University of Texas at Dallas

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Aortopathy including aneurysms, dissection, and rupture are life-threatening diseases that have no validated medications. The only therapeutic option is watchful waiting prior to major surgical intervention. This project will provide novel mechanistic insight into these diseases that will enable more focused efforts in understanding the disease pathogenesis and developing medical treatment.

PI_NAMEs: DAUGHERTY, ALAN  (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TITLE: Determinants of Aorta Heterogeneity


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH Cardiovascular calcification is a highly prevalent process whereby bone mineral forms in the heart tissue and blood vessels, and it contributes to a number of debilitating cardiovascular diseases, including chronic heart failure and myocardial infarction. Recent work has implicated endothelial-to-mesenchymal transition (EndMT) in the development of cardiovascular calcification, but while agents targeting the EndMT process may be promising, the current assessments of EndMT have inherent limitations that impede our ability to efficiently evaluate the efficacies of investigative therapies. In this proposal, we aim to characterize a novel component of EndMT– its mechanical properties or “mechanophenotype” – with the goal of developing innovative platforms to investigate the mechanobiological mechanisms of EndMT, and to identify and test therapeutic targets for EndMT and cardiovascular calcification in a high-throughput, resource-efficient manner.

PI_NAMEs: HSU, JEFFREY JOHN (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Acceleration;Adult;Aorta;Apolipoprotein E;Arterial Fatty Streak;Attenuated;Balloon Angioplasty;biomechanical test;biomineralization;Blood Vessels;bone;calcification;Calcium;Cardiovascular Diseases;cardiovascular health;Cardiovascular Pathology;Cardiovascular system;career;career development;Cell Line;Cells;Cerebral Infarction;Complex;Congestive Heart Failure;cytokine;Cytoskeleton;Deposition;Detection;Development;Disease;efficacy evaluation;Embryo;Endothelial Cells;Endothelium;Event;experimental study;Foundations;Gene Expression;Genetic;Goals;Heart;Heart Valves;Histologic;improved;in vivo;Individual;Inflammatory;innovation;insight;interstitial;Investigation;K-Series Research Career Programs;mechanical properties;Mechanics;Mediating;Medical;Mentors;Mentorship;Mesenchymal;Methods;migration;Minerals;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;Myocardial Infarction;National Heart, Lung, and Blood Institute;Nature;novel;Osteogenesis;osteogenic;Pathologic;Pathologic Processes;personalized medicine;physician-scientist training program;Physiological Processes;Population;Predisposition;pressure;Process;Property;protein expression;PTH gene;Public Health;Research;Research Personnel;Resolution;Resources;Risk;Rupture;sex;Signal Transduction;Sodium Fluoride;Speed;Stress;targeted agent;targeted treatment;Techniques;Testing;therapeutic evaluation;Therapeutic Intervention;therapeutic target;Time;Tissues;TNF gene;Training;transcription factor;Translational Research;Vascular calcification;western diet;Work;X-Ray Computed Tomography

PROJECT_TITLE: Mechanobiology of Endothelial-to-Mesenchymal Transition in Cardiovascular Calcification

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Vaccine Related

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative The lung contains resident memory immune cells that are established in the setting of local infection, and are crucial in protecting the host from future pulmonary infections by related, but different pathogens. Despite recent research advances, pulmonary infections are still a major cause of death worldwide, and vaccines that elicit protective heterotypic immunity do not exist for many respiratory pathogens. Here, we propose studies aimed at defining mechanisms of establishment and function of lung resident memory B cells, as advancing our understanding of how lung B cells mediate heterotypic immunity will aid in the development of effective vaccines for respiratory infections.

PI_NAMEs: ETESAMI, NEELOU  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 2019-nCoV;Adult;Age;Aging;Allergens;Antibodies;Antigen Presentation;Antigens;Architecture;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;Bacterial Infections;Body part;Cause of Death;CD19 gene;CD4 Positive T Lymphocytes;CD80 gene;Cell Communication;Cell Physiology;Cell secretion;Cell Shape;Cell surface;Cells;Cellular biology;chemokine;Child;community acquired pneumonia;Coronavirus;COVID-19 pandemic;cross reactivity;CXCL13 gene;Data;Development;Disease;emerging pathogen;Environment;enzyme linked immunospot assay;Etiology;Exposure to;Flow Cytometry;Fluorescence-Activated Cell Sorting;Focal Infection;Future;Generations;Health;Host Defense;Human;Immune;Immunity;Immunofluorescence Immunologic;Immunofluorescence Microscopy;Immunoglobulin Class Switching;Immunoglobulin M;Immunoglobulin-Secreting Cells;Immunoglobulins;Immunologic Memory;improved;in vivo;Infection;Inhalation;Lower Respiratory Tract Infection;Lung;Lung immune response;Lung infections;Lymphoid Tissue;Measures;Mediating;Mediator;Memory;Memory B-Lymphocyte;memory CD4 T lymphocyte;Microbe;Modeling;Morbidity - disease rate;mortality;Mus;neutralizing antibody;pathobiont;pathogen;Pattern;Phenotype;Play;Pneumococcal Infections;Pneumonia;Population;prevent;Prevention strategy;Process;programmed cell death protein 1;Property;pulmonary function;rational design;Reaction;Research;resilience;respiratory pathogen;Respiratory Tract Infections;response;Role;Serotyping;Streptococcus pneumoniae;Structure of germinal center of lymph node;T-Cell Development;T-Lymphocyte;tertiary lymphoid organ;Testing;theories;Therapeutic;Tissues;tool;Transgenic Mice;United States;Vaccine Design;Vaccines;Variant;Viral;Virus Diseases;young adult

PROJECT_TITLE: Protective lung memory B cell functions and dynamics during respiratory infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07-U(20)L]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Mammograms can serve a dual function - screening for breast cancer and looking for evidence of cardiovascular disease (breast arterial calcification, BAC) – without additional radiation to the patient, without increasing mammography appointment length, and adding only minimally to breast radiologist time. Reporting BAC directly to patients as part of standard mammography practice could uniquely promote prevention, diagnosis, and treatment of cardiovascular disease in women, which is the main cause of death among women in the United States. The primary goals of this study are to investigate the effects of informing patients about their BAC results (versus a Waitlist Control) on their cardiovascular health behaviors (attending a cardiovascular appointment, improving heart healthy behavior) and on their likelihood of receiving a diagnosis of coronary artery disease.

PI_NAMEs: MONTGOMERY, GUY H (contact)

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: Affect;Appointment;Arteries;base;Behavior;Breast;Breast Cancer Detection;calcification;cancer prevention;Cardiac Death;Cardiology;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Caring;Cause of Death;Communication;Communities;Complement;Consent;Control Groups;Coronary Arteriosclerosis;Coronary artery;coronary artery calcification;Data;Demographic Factors;design;Detection;Diagnosis;Diet;Digital Mammography;disorder risk;Early identification;Eligibility Determination;Ensure;ethnic diversity;Ethnic Origin;Failure;follow-up;General Population;Goals;Health behavior;Health Benefit;health data;Heart;Image;improved;innovation;Intervention;Intervention Studies;Learning;Length;Letters;Life Style;lifestyle factors;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Measures;Mediating;Medical;Modeling;Myocardial;Myocardial Infarction;Outcome;Outcome Study;Participant;Patient Preferences;Patients;Population Study;Postmenopause;Prevalence;Prevention;Preventive;Preventive care;primary outcome;Process;Psychological Factors;Public Health;Race;racial diversity;Radiation;radiologist;Randomized;randomized trial;Recommendation;recruit;Reporting;Research;routine screening;Sampling;screening;Screening for cancer;Screening procedure;Spanish/English;Symptoms;Testing;Text;Time;United States;Visit;Waiting Lists;Woman;Women's Health;Women's mortality

PROJECT_TITLE: Enhancing the public health benefits of mammography screening by informing women of both breast cancer and breast arterial calcification results: A randomized trial to promote cardiovascular health

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: Project Narrative Alcohol-associated liver disease (ALD) is responsible for a significant proportion of liver disease deaths, yet there are no FDA-approved therapies for the treatment of any stage of its progression, and the underlying mechanisms of disease progression are still under investigation. Mitogen-activated protein kinase phosphatase 1 (MKP-1), a key regulator of tissue inflammation and injury, is downregulated in the livers of alcohol-fed mice and ethanol-exposed hepatocytes. Complete assessment of the role of decreased MKP-1 expression in both hepatocytes and immune cells in the progression of ALD might lead to novel therapeutic targets for the treatment of ALD.

PI_NAMEs: WALTER, MARY NANCY (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: alcohol effect;alcohol exposure;Alcoholic beverage heavy drinker;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Apoptotic;Area;Basic Science;career;career networking;Cell Count;Cell Line;Cell model;Cells;Cessation of life;chemokine;Chronic;Cirrhosis;Clinical;cytokine;Data;Development;Disease;Disease Progression;Down-Regulation;Endotoxins;Ethanol;experience;FDA approved;Fostering;Galactosamine;Goals;Health;Hepatic;Hepatitis;Hepatocyte;hepatocyte injury;Immune;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Injury;Intestinal permeability;intrahepatic;Investigation;Knockout Mice;Kupffer Cells;Laboratories;Learning;Liver;Liver diseases;liver inflammation;liver injury;LoxP-flanked allele;Macrophage;MAPK1 gene;MAPK8 gene;Mediating;Medical;member;Mentors;microbial products;Mitogen-Activated Protein Kinases;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myeloid Cells;N-terminal;National Institute on Alcohol Abuse and Alcoholism;new therapeutic target;novel;novel therapeutics;oral communication;Organ;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathology;Phenotype;phosphatase-1 kinase;Phosphoric Monoester Hydrolases;Phosphotransferases;Play;Portal vein structure;Predisposition;Primary carcinoma of the liver cells;Production;Research;Research Personnel;response;Role;Scientist;Severity of illness;Signal Transduction;simple steatosis;skills;Specificity;Steatohepatitis;Supervision;Techniques;Testing;Tissues;TNF gene;Toxic effect;Training;western diet;Work;Writing

PROJECT_TITLE: The role of MKP-1/MAPK in hepatocytes and macrophages in alcohol-associated liver disease pathogenesis


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Infectious Diseases;Neurosciences

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Toxoplasma gondii is the leading cause of infectious retinitis worldwide and is a neglected parasitic infection in the United States with over 11% of the population testing seropositive. Recent work conducted by the Subauste lab has demonstrated that T. gondii can manipulate host cell signaling to prevent degradation by the autophagolysosome, thus preventing this signaling can result in therapeutic implications by promoting autophagic eradication of the parasite. The mechanism for autophagosome formation during T. gondii infection has yet to be elucidated and will identify a possible novel mechanism of selective autophagy.

PI_NAMEs: HUBAL, ALYSSA  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;AKT inhibition;Autophagocytosis;Autophagolysosome;Autophagosome;Binding Proteins;Biogenesis;Blindness;cell type;Cells;Chronic;Cyclic AMP-Dependent Protein Kinases;Data;Deposition;Disease;EGFR inhibition;Encephalitis;Endoplasmic Reticulum;Epidermal Growth Factor Receptor;Event;experimental study;Eye;Eye diseases;Galactose Binding Lectin;Gefitinib;Impairment;improved;In Vitro;in vivo;Infectious Agent;inhibitor;Invaded;knock-down;Lysosomes;Mediating;Membrane;Molecular;Mus;neglect;neural;new therapeutic target;novel;obligate intracellular parasite;Ocular Toxoplasmosis;Outcome;parasite invasion;Parasites;Parasitic infection;pathogen;Patients;Population;prevent;Protein Kinase;Proteins;PTK2 gene;receptor;recruit;recurrent infection;Resistance;Retina;Retinitis;Role;seropositive;Signal Transduction;Signaling Molecule;Source;STAT3 gene;Testing;Therapeutic;Tissues;Toxoplasma gondii;Toxoplasmosis;Treatment outcome;Tyrosine Kinase Inhibitor;Ubiquitin;United States;Vacuole;Vision;Visual;Work

PROJECT_TITLE: Src Inhibition Induces Selective Autophagic Killing of T. gondii Independently of EGF Receptor


ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project Narrative The structurally complex t6A RNA modification is essential in virtually all bacteria. The proposed research will elucidate the molecular and structural basis for its formation in bacterial transfer RNA, and uncover the linkage between this modification pathway and other metabolic systems. The results of this research will facilitate the development of a new class of molecular targets for antibacterial agents to combat microbial diseases.

PI_NAMEs: SWAIRJO, MANAL A (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Active Sites;Address;Amino Acyl-tRNA Synthetases;Anabolism;Anti-Bacterial Agents;Anticodon;ATP Hydrolysis;ATP phosphohydrolase;Bacteria;Biochemical;Bioinformatics;Cell Cycle Regulation;Cell division;Cell Physiology;Cell Wall;Chemicals;Chemistry;Codon Nucleotides;Collaborations;combat;Comparative Genomic Analysis;Complex;Data;Defect;Development;Elements;Enzymatic Biochemistry;Enzymes;experimental study;Foundations;Funding;Genetic;genetic information;Genome;Goals;Gram-Negative Bacteria;human disease;Indiana;Initiator Codon;insight;Institution;Kinetics;Laboratories;Life;Link;Measures;Metabolic;Metabolic Pathway;Metabolism;Methods;microbial disease;Microbial Genetics;Modification;Molecular;Molecular Target;multidisciplinary;Mutagenesis;mutant;novel;Nucleotides;Organism;Outcome;Pathway interactions;Peptidoglycan;Phenotype;Phosphorylation;Phosphotransferases;Physiological;Play;Positioning Attribute;posttranscriptional;prevent;Process;Productivity;programs;Protein Dephosphorylation;Proteins;Pseudomonas putida;Recycling;Regulation;Regulatory Pathway;Reporting;Research;Ribosomal Frameshifting;RNA;RNA Sequences;Role;Specificity;stem;Streptococcus pneumoniae;Structural Biochemistry;structural biology;System;Therapeutic Intervention;Transfer RNA;Translations;virtual;Work

PROJECT_TITLE: RNA modification: Mechanism and links to other metabolic pathways

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Congenital Structural Anomalies;Digestive Diseases;Genetics;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE / RELEVANCE Identifying and understanding the molecular mechanisms underlying the biliary system formation will offer new opportunities for therapeutic intervention for biliary system diseases, including biliary atresia. This study utilizes forward genetic approaches in zebrafish to investigate the genetic factors and pathways responsible for proper biliary system formation and the pathogenesis of biliary atresia.

PI_NAMEs: SAKAGUCHI, TAKUYA  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Algorithms;Animal Model;Biliary;Biliary Atresia;biliary tract;Bioinformatics;Caroli Disease;CDK5 gene;Childhood;Cholestasis;Cirrhosis;Classification;classification algorithm;Cloning;Complex;Computational algorithm;computerized tools;Data;Defect;Development;Disease;Etiology;experimental study;Fibrosis;Funding;Future;Gene Mutation;Genes;Genetic;genetic analysis;genetic approach;Genetic Complementation Test;Genetic Screening;Goals;Human;human model;Immune;Impairment;in silico;infancy;Infant;innovation;insight;intrahepatic;Larva;Liver;Liver diseases;liver injury;liver transplantation;machine learning algorithm;malformation;Mediating;Methods;microdeletion;Molecular;Morphogenesis;mutant;Mutate;Mutation;Neonatal;next generation sequencing;Obstruction;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern;Phenotype;Phosphotransferases;Play;positional cloning;Resources;Role;Sampling;Signal Pathway;Signal Transduction;Specimen;Systems Development;Testing;Therapeutic Intervention;tool;unsupervised clustering;Work;Zebrafish

PROJECT_TITLE: Forward genetic analysis of biliary system formation

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Bioengineering;Hematology

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: Project Narrative The proposed studies address the structural underpinnings of the function of protein C as a key regulator of the blood coagulation response. Progress in this area will impact basic knowledge of the pathophysiology of blood coagulation and its therapeutic control.

PI_NAMEs: DI CERA, ENRICO  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: activated Protein C;Active Sites;Acute;Address;Anticoagulants;Architecture;Area;Binding;Biological;Biology;biophysical techniques;Blood coagulation;Blood Coagulation Factor;Coagulation Process;cofactor;Complement;Complex;Cryoelectron Microscopy;data acquisition;Development;Disease;Docking;EGF gene;Electrostatics;Engineering;Enzymatic Biochemistry;Enzyme Precursors;Enzymes;Epitopes;expectation;Exposure to;Factor V;Factor Va;Factor Xa;Feedback;Fibrinolysis;Fluorescence Resonance Energy Transfer;Functional disorder;Human;innovation;interest;Investigation;Kinetics;Knowledge;Length;macromolecule;Maps;Molecular;Molecular Conformation;particle;Peptide Hydrolases;Peptides;Positioning Attribute;Protease Domain;Protein C;protein function;Protein S;protein structure;Proteins;Prothrombin;prothrombinase complex;Regulation;Research;Research Project Grants;Resolution;response;scaffold;Shapes;Side;single molecule;Site;Solvents;Specificity;Structure;success;Techniques;Tertiary Protein Structure;Testing;Therapeutic;Thrombin;Thrombomodulin;Time;Variant;X-Ray Crystallography

PROJECT_TITLE: Structural enzymology of protein C

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Human Genome

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Genetic variation dictates an individual’s risk of developing common ailments such as heart and blood diseases. Traditionally, it has been difficult to determine which of the millions of sequence variants influence disease susceptibility due to a lack of technologies that enable the causal assignment of genetic variants at scale. To address this unmet need, we will develop a generalizable pipeline that leverages technological breakthroughs in precise genome editing to unravel the functional impact of genetic variation on heart and blood disease risk, offering a rich catalog of the consequences of thousands of disease-associated variants that will be of broad utility to the Impact of Genomic Variation on Function (IGVF) Consortium and wider biomedical community.

PI_NAMEs: BAUER, DANIEL EVAN;LETTRE, GUILLAUME ;PINELLO, LUCA  (contact);SHERWOOD, RICHARD I

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Address;base editing;base editor;Biological;Biological Assay;Blood;Blood Cells;blood lipid;Blood Platelets;Blood Pressure;Cardiovascular Diseases;Cardiovascular system;Catalogs;causal variant;Cell Line;Cell Physiology;Cells;Cellular Assay;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;computational pipelines;Computing Methodologies;Coronary Arteriosclerosis;CRISPR interference;CRISPR screen;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;Data Collection;Data Set;data sharing;design;Development;Disease;Disease susceptibility;disorder risk;Dissection;Dyslipidemias;Elements;Epigenetic Process;Erythrocytes;Ethnic Origin;Etiology;Fetal Hemoglobin;follow-up;Frequencies;functional genomics;Gene Expression;Gene Frequency;Genes;Genetic;genetic association;genetic variant;Genetic Variation;Genome;genome editing;genome wide association study;genomic variation;Genotype;Goals;Heart Diseases;Hematological Disease;Hematology;Hemoglobin concentration result;High Density Lipoprotein Cholesterol;high throughput screening;Human;human disease;Human Genetics;Hypertension;Individual;LDL Cholesterol Lipoproteins;Leukocytes;Link;Machine Learning;Maps;Measures;Methods;Modeling;Molecular;multi-ethnic;multimodality;neutrophil;next generation;novel therapeutic intervention;open source;Patients;Phenotype;Positioning Attribute;precise genome editing;predictive modeling;Probability;programs;Regulatory Element;Reporting;Research;Risk;Risk Factors;Scheme;screening;Serum;sex;single-cell RNA sequencing;Technology;Testing;trait;Validation;Variant;Visualization;working group;Writing

PROJECT_TITLE: Comprehensive characterization of variants underlying heart and blood diseases with CRISPR base editing


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome

ORG_CITY: AMHERST

ORG_DEPT: DENTISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative  The development, differentiation and functional maturation of the salivary gland is a tightly regulated process that requires the coordinated activity of important transcriptional networks and signaling pathways. This application focuses on examining the gene-regulatory mechanisms, and in particular the role of the transcription factor Xbp-1, in directing morphogenesis, cellular identity and fate. Such studies will lead to an improved understanding of the inner workings of the salivary gland and can provide molecular insights into regeneration processes that can help patients with salivary gland dysfunction.

PI_NAMEs: WRYNN, THERESA  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Ablation;Acetylation;Acinar Cell;Address;Adult;Antibodies;Area;Automobile Driving;Binding;Binding Proteins;Bioinformatics;Biological;Biological Assay;Biological Process;Biology;Cell Differentiation process;Cell Lineage;Cell Maintenance;Cell Physiology;cell type;Cells;ChIP-seq;chromatin immunoprecipitation;Complex;conditional knockout;Critical Pathways;Data;Data Set;Development;Differentiated Gene;Differentiation Antigens;Disease;Embryo;Embryonic Development;Enhancers;Ensure;epigenomics;Equilibrium;experimental study;Factor X;Functional disorder;Gene Expression;gene regulatory network;Genes;Genetic;genetic approach;Genetic Transcription;Genomics;Gland;gland development;Goals;Histologic;Histones;Homeostasis;Human;improved;in vivo;in vivo Model;insight;interest;knockout animal;Knockout Mice;Knowledge;Lysine;Maintenance;Maps;Measures;Mediating;Mediator;Mining;Molecular;Morphogenesis;Morphology;mouse model;Mus;Muscarinic Acetylcholine Receptor;Natural regeneration;Neonatal;Normal tissue morphology;Organogenesis;Outcome;Pathway interactions;Patients;Pattern;Phenotype;Play;polarized cell;Polymerase Chain Reaction;Population;postnatal;Process;programs;Proliferating;Protein Isoforms;Proteins;Publishing;Quantitative Reverse Transcriptase PCR;regeneration following injury;Regulatory Element;response;RNA Splicing;Role;saliva mediated;saliva secretion;Salivary;Salivary Gland Diseases;Salivary Glands;Signal Pathway;Signal Transduction;single-cell RNA sequencing;spatiotemporal;Structure;Submandibular gland;Systems Biology;Testing;Therapeutic;therapeutic target;Tight Junctions;Time;tissue regeneration;Tissues;transcription factor;transcriptome sequencing;transcriptomics;XBP1 gene;Xerostomia

PROJECT_TITLE: Genetic and molecular mechanisms of Xbp-1 mediated salivary gland development and differentiation

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Pediatric

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Current functional near-infrared spectroscopy systems have some technical restrictions that limit the extent of whole brain functional imaging. In this application, we propose to develop a whole brain, functional near- infrared spectroscopy system that is sensitive and rapid enough for assessing brain hemodynamic activity in infants. This imaging technique will allow economical, bedside diagnostics for prognostication and, hopefully in the future, strategic therapeutic interventions that can positively alter outcomes.

PI_NAMEs: ZHU, BANGHE  (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Adult;Algorithms;awake;Basal Ganglia;blood oxygen level dependent;Brain;Brain imaging;Calibration;Cephalic;Cerebral cortex;cerebral hemodynamics;Cerebral Palsy;Child;Child Care;Childhood;Clinical;Clinical Data;clinical imaging;Collection;Data;data acquisition;density;detector;Developmental Delay Disorders;Devices;Diagnostic;diffuse optical tomography;digital;Disabling;Engineering;Epilepsy;experience;experimental study;Fiber;Fiber Optics;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;functional MRI scan;functional near infrared spectroscopy;Future;gallium arsenide;Goals;hemodynamics;Hemoglobin;Image;image reconstruction;Imaging Device;imaging system;Imaging Techniques;Impaired cognition;Infant;infant brain injury;innovation;instrumentation;Light;Maps;Measurement;Mechanics;Metabolism;Methodology;millisecond;Motor;Movement Disorders;Near-infrared optical imaging;network dysfunction;neuroimaging;Neurosurgeon;neurosurgery;neurovascular coupling;novel;optical imaging;optical switch;Optical Tomography;Optics;Outcome;Parents;Performance;Physicians;Premature Infant;prevent;prognostic;prognostication;Proxy;Quality of life;Reporting;Research;Resolution;Risk;Scalp structure;Science;Signal Transduction;Source;spatiotemporal;spectroscopic imaging;Speed;Structure;System;Techniques;temporal measurement;Thalamic structure;Therapeutic Intervention;Three-Dimensional Imaging;Time;Work

PROJECT_TITLE: A fast CTOT for mapping whole brain hemodynamic activity in infants

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative The underlying mechanisms by which variants modify Alzheimer's disease risk remain unknown. This proposal combines patient-derived induced pluripotent stem cells and innovative xeno-transplantation techniques to experimentally investigate the impact of disease risk modifying variants on cellular function of disease-relevant microglia in vitro and in vivo. The work here has the potential to greatly impact public health through enhancing our understanding of how genes, and their variants within them, affect immune cell function and modify disease risk and evaluating the therapeutic potential of a disease-modifying drug.

PI_NAMEs: GARRETTI, FRANCESCA  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: activating transcription factor 4;Affect;Age;Age Years;Alleles;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Amino Acid Substitution;Amyloid deposition;Apolipoprotein E;Bacteria;biological adaptation to stress;Biological Assay;Brain;career;Cell Physiology;Cells;Cellular Stress;Cholesterol;Clinical;Cognitive;collaborative environment;Complex;CRISPR/Cas technology;Critical Thinking;cytokine;Deposition;Disease;disorder risk;efficacy testing;EIF2B2 gene;enzyme activity;Exhibits;Fellowship;Fluorescence;Genes;genetic risk factor;Genetic study;genetic variant;genome wide association study;Genotype;Goals;Guanine;Guanine Nucleotide Exchange Factors;Hematopoietic stem cells;High Pressure Liquid Chromatography;Homeostasis;Human;Human Genetics;human induced pluripotent stem cells;humanized mouse;Immune;Immunocompromised Host;Immunohistochemistry;Impaired cognition;Impairment;improved;In Vitro;in vitro activity;in vivo;Individual;induced pluripotent stem cell;Inflammation;Inflammatory;inhibitor;inhibitor therapy;Injections;innovation;Knowledge;live cell imaging;Measures;Mediating;medical schools;Mentorship;Messenger RNA;Methods;Microglia;Morphology;mouse model;Mus;mutant;Mutation;Myelin;Nerve Degeneration;novel;novel therapeutics;Outcome;Pathway interactions;patient derived induced pluripotent stem cells;Phagocytes;Pharmaceutical Preparations;Phenotype;Phosphorylation;precursor cell;Production;Productivity;Proliferating;Protein Biosynthesis;Protein Isoforms;protein purification;Proteins;Public Health;Research Personnel;response;Risk;risk variant;Role;Scientist;Senile Plaques;Single Nucleotide Polymorphism;single nucleus RNA-sequencing;skills;Stress;stressor;Structural Chemistry;Structure;Technical Expertise;Techniques;Testing;Thapsigargin;Therapeutic;Training;transcription factor;transcriptomics;Translations;Transplantation;Variant;Work;Xenograft procedure

PROJECT_TITLE: Investigating the role of an EIF2B3 variant as an Alzheimer's disease risk modifier


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: LA JOLLA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE Epilepsy is a devastating neurological illness, affecting over 50 million people world-wide. In this project, we will leverage the ENIGMA-Epilepsy infrastructure to address how quantitative, non-invasive neuroimaging, clinical and genetic data can be used to predict (1) which patients will respond to anti-seizure medications versus which will remain drug-resistant and (2) which patients will achieve favorable versus unfavorable surgical outcomes. The research will be accomplished by applying a series of hypothesis-driven and data- driven (i.e., machine learning) approaches to clinical and imaging data on an exceptionally large cohort of patients with common epilepsy syndromes, providing unprecedented power to tackle critical treatment-related questions in epilepsy.

PI_NAMEs: MCDONALD, CARRIE R (contact);PARDOE, HEATH ;SISODIYA, SANJAY ;THOMPSON, PAUL M

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Address;Affect;Anticonvulsants;Benchmarking;Bilateral;Brain;brain abnormalities;Characteristics;Classification;Clinical;clinical biomarkers;Clinical Data;clinical risk;cohort;Communities;comorbidity;connectome;Country;Coupled;Data;data harmonization;Data Set;Databases;design;determinants of treatment resistance;Development;Diagnosis;Diagnostic;Diffusion Magnetic Resonance Imaging;Disease;Drug resistance;drug response prediction;Ensure;Epilepsy;Evaluation;Failure;Freedom;frontal lobe;Frontal Lobe Epilepsy;Generalized Epilepsy;Genetic;Genetic Markers;Genetic Risk;genetic risk factor;Genetic Variation;Geography;Grant;Health;Heterogeneity;Human;human old age (65+);Image;imaging biomarker;improved;Individual;individual patient;Infrastructure;insight;interest;Intractable Epilepsy;large datasets;large scale data;Lesion;Lifting;Lobe;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;Meta-Analysis;Methods;Modeling;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;network models;neuroimaging;Neurologic;Newly Diagnosed;Operative Surgical Procedures;Outcome;Partial Epilepsies;patient response;Patient-Focused Outcomes;Patients;Pattern;Persons;Pharmaceutical Preparations;Play;polygenic risk score;Postoperative Period;predicting response;Prediction of Response to Therapy;Property;quantitative imaging;Reproducibility;Reproducibility of Results;Research;Resources;response;Risk Factors;Role;Sample Size;Sampling;Seizures;Series;Site;surgery outcome;Syndrome;Technology;Temporal Lobe Epilepsy;Testing;Treatment outcome;treatment planning;United States National Institutes of Health;Visual

PROJECT_TITLE: Identifying brain networks to predict treatment resistance and post-surgical outcome: An ENIGMA-Epilepsy initiative

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Microbiome

ORG_CITY: ITHACA

ORG_DEPT: NUTRITION

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Sphingolipids regulate processes connected to fitness in both hosts and their beneficial gut microbes. This project aims to define how the interchange of sphingolipids between host and microbe affects symbiosis with the goal of manipulating these exchanges for the benefit of human health.

PI_NAMEs: JOHNSON, ELIZABETH L (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Contraception/Reproduction;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE This work will contribute significantly to what is known about the mechanisms promoting regeneration in living adult animals. By using complimentary genetic and genome-wide approaches in the Drosophila testis, we will identify the cellular and molecular mechanisms that enable tissues to sense damage and then activate a program to regenerate missing stem cells. These mechanisms are of strong general interest, as they will suggest successful therapeutic strategies for achieving healthy tissue regeneration more generally.

PI_NAMEs: MATUNIS, ERIKA L (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adopted;Adult;adult stem cell;Automobile Driving;Biological;Biological Models;Biology;Cell Differentiation process;cell growth regulation;cell type;Cells;Collection;Drosophila genus;Fertility;Genetic;genome-wide;Germ Cells;germline stem cells;Goals;Growth;Homeostasis;Image;Injury;interest;Malignant Neoplasms;mature animal;Molecular;Natural regeneration;Normal tissue morphology;Organ;Pathway interactions;programs;Property;response;response to injury;Signal Transduction;single-cell RNA sequencing;Spermatogenesis;stem cell biology;stem cells;Testis;Therapeutic;tissue regeneration;tissue repair;Tissues;tool;transdifferentiation;Work

PROJECT_TITLE: Regulation of cellular plasticity and regeneration in Drosophila spermatogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: This training grant provides a summer research experience for medical students at Wake Forest School of Medicine with research focus on diabetes, digestive and kidney disease, obesity, and related disorders. It has the goal to inspire medical students to become involved in research during subsequent specialty training and careers as health care providers. Dedicated faculty mentors allow students a first-hand experience conducting state-of-the-art biomedical research in the context of a learning healthcare system, supplemented by didactic seminars and workshops, to communicate to medical students how clinical care and research should inform each other, with the goal of providing more benefit to patients and society.

PI_NAMEs: MCCLAIN, DONALD A. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Area;Clinical;Clinical Sciences;clinical training;Competence;Continuing Education;Critical Thinking;Decision Making;Dedications;Diabetes Mellitus;Digestive System Disorders;Disease;Doctor of Philosophy;Education;Elements;Ethics;Event;evidence base;Evidence Based Medicine;experience;Faculty;faculty mentor;Fostering;Funding;health disparity;Health system;Immersion;interest;Leadership;Learning;medical schools;Medical Students;Mentors;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Obesity associated kidney disease;Office of Administrative Management;Oral;posters;Program Evaluation;programs;Qualifying;Recording of previous events;Reproducibility;Research;Research Design;Research Training;responsible research conduct;Role;Scientist;Self Assessment;skills;Students;summer program;summer research;Testing;Training;Training Programs;Translational Research;United States National Institutes of Health;verbal;Work;Writing

PROJECT_TITLE: Wake Forest Short-term Research Training Program

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Cancer

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE BCL-2 family proteins are essential arbiters of programmed cell death during development and homeostasis and when deregulated contribute to the development, maintenance, and chemoresistance of human cancers. A critical missing link in our understanding of the apoptotic pathway is how BAX, an essential executioner protein, self-assembles into higher-order oligomers to permeabilize the mitochondrial outer membrane. The goal of my research is to harness cutting-edge nanobody technology and the first homogeneous species of oligomeric BAX to provide new structural insight into the execution phase of BAX-mediated apoptosis and thereby inform new opportunities to modulate BAX for therapeutic benefit in cancer.

PI_NAMEs: YU, ELLEN  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Affinity;Affinity Chromatography;Apoptosis;Apoptosis Regulation Gene;Apoptotic;arm;BAX gene;BCL-2 Protein;BCL1 Oncogene;BCL2 gene;Binding;Binding Sites;Biochemical;Biochemistry;Biological Assay;Cancer Biology;cancer cell;Cell Death;Cell Membrane Permeability;Cells;Cellular Stress;Cessation of life;Chemoresistance;Choline;Clinical Oncology;comparative;Complex;Cryoelectron Microscopy;cytochrome c;Cytosol;Dana-Farber Cancer Institute;Detergents;Deuterium;Development;Dissection;Electron Microscopy;Epitopes;Escherichia coli;Exposure to;Family;Goals;Homeostasis;Homo;Human;Hydrogen;In Vitro;Incubated;Induction of Apoptosis;innovation;insight;Laboratories;Length;Leukemic Cell;Link;Liposomes;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;MCL1 gene;Mediating;medical schools;member;Membrane;membrane model;Methods;Microscopy;Mitochondria;Molecular;Molecular Chaperones;Molecular Conformation;Molecular Sieve Chromatography;Monitor;monomer;multidisciplinary;Mutagenesis;mutant;nanobodies;Negative Staining;next generation sequencing;novel;Outer Mitochondrial Membrane;overexpression;Pathway interactions;Permeability;Phase;Physicians;preservation;prevent;programs;Protein Engineering;Protein Family;Proteins;Protocols documentation;Recombinant Proteins;refractory cancer;Relapse;Research;Resolution;response;Roentgen Rays;Rupture;Scientist;self assembly;Site-Directed Mutagenesis;Stress;structural biology;structural determinants;Structure;Surface;Technology;Therapeutic;tool;Training Programs;tumorigenesis;X-Ray Crystallography;Yeasts

PROJECT_TITLE: Nanobodies for Dissecting the Structure and Function of Oligomeric BAX


ADMINISTERING_IC: DA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: HANOVER

ORG_DEPT: PSYCHIATRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: OVERALL CORE CENTER PROJECT NARRATIVE Behavioral treatments delivered on digital platforms can scale-up access to substance use disorder (SUD) care at a population level and reduce the striking disparities in treatment access and treatment quality evident across healthcare settings. The Center for Technology and Behavioral Health will continue to serve as a national and global leader in the field of digital therapeutics for SUDs by accelerating the development, evaluation, and implementation of scalable, science-based treatments for SUDs while training the next generation of SUD researchers in digital health research.

PI_NAMEs: MARSCH, LISA A. (contact)

PROGRAM_OFFICER_NAME: AKLIN, WILL

PROJECT_TERMS: Acceleration;Achievement;Address;Adolescent;Adoption;Adult;Area;authority;Authorization documentation;Awareness;behavior change;Behavior Therapy;behavioral health;care outcomes;Caring;Clinical;Communication;Computer software;Congresses;cost;cost effectiveness;Data Analytics;Development;Diagnostic;digital applications;digital delivery;digital health;digital intervention;digital phenotyping;digital platform;digital treatment;Discipline;Disease;Dissemination and Implementation;diversity and inclusion;dual diagnosis;Education;Effectiveness;Emerging Technologies;Ensure;Ethics;Evaluation;evidence base;Funding;Future;Grant;health assessment;health care settings;Health Services Accessibility;Healthcare;HIV risk;implementation efforts;Improve Access;Industry;Infrastructure;innovation;International;Intervention;intervention delivery;Knowledge;Leadership;Link;Measurement;Medical;Mental disorders;Mental Health;Mentorship;Methodology;Methods;mobile sensing;Modeling;National Institute of Drug Abuse;next generation;novel;Phase;physical conditioning;Pilot Projects;Population;prevent;Process;Productivity;Publications;Quality of Care;Research;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Resource Sharing;Resources;Risk Behaviors;scale up;Science;Substance Use Disorder;substance use treatment;symposium;synergism;System;Technology;Testing;Therapeutic;therapeutic target;therapy development;Training;treatment disparity;Treatment outcome;Underrepresented Minority;United States Substance Abuse and Mental Health Services Administration;Work

PROJECT_TITLE: Technology-based Treatments for Substance Use Disorders


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Social Determinants of Health;Substance Misuse

PHR: NARRATIVE AND RELEVANCE  Policies regulating marijuana retail sale have been designed and implemented in the absence of scientific knowledge about how individuals make purchase decisions and what regulatory measures would be effective to reduce problem marijuana use. The overarching goal of the proposed research is to test a series of hypotheses on the relationships between recreational marijuana regulatory strategies and individual preferences for marijuana products. As recreational marijuana legalization and commercialization continue to be adopted, our study findings are expected to provide critical public health implications regarding marijuana regulation and control in the new legal regime.

PI_NAMEs: SHI, YUYAN  (contact)

PROGRAM_OFFICER_NAME: KIMMEL, HEATHER L

PROJECT_TERMS: 21 year old;Address;Adopted;Adoption;Adult;Alcohol consumption;Attention;Baseline Surveys;Behavior;behavioral economics;Calibration;Cannabis policy;Cannabis retail;Characteristics;cognitive load;Collaborations;commercialization;Complement;Data;design;District of Columbia;Effectiveness;Etiology;Evaluation;experience;experimental study;Flowers;follow-up;Future;Goals;Heterogeneity;Individual;individual variation;innovation;Investigation;Knowledge;Legal;Longitudinal cohort;Marijuana;marijuana legalization;marijuana use;marijuana user;Market Research;Marketing;Measures;Medical;Methodology;Methods;novel;Online Systems;Patient Self-Report;Policies;policy implication;Population;preference;Price;Public Health;Recreation;recruit;Regulation;Research;Respondent;Sales;Sampling;Series;Solid;Source;Surveys;Testing;Tobacco use

PROJECT_TITLE: Using Behavioral Economics Approach to Examine Individual Preferences for Marijuana Products

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Social Determinants of Health;Substance Misuse

PROJECT_TERMS: Achievement;AIDS prevention;Applications Grants;behavior change;behavioral health;Cellular Phone;Collaborations;college;Communication;cost effective;Data Analytics;Decision Making;design;Development;digital treatment;Discipline;Doctor of Philosophy;Emerging Technologies;Ensure;Ethics;experience;Funding;Generations;Geography;health economics;Human Resources;implementation science;Individual;Infrastructure;innovation;Institution;Intervention;intervention delivery;Knowledge;Leadership;Light;Literature;Location;meetings;member;Mental Health;Methodology;Methods;mHealth;Mission;Modeling;novel;Organization administrative structures;organizational structure;Parents;Pilot Projects;Privacy;Process;Productivity;Protocols documentation;Public Policy;Publications;Qualifying;Quality Control;Regulation;Research;Research Activity;Research Project Grants;Resources;Science;Security;social media;Structure;Substance Use Disorder;substance use treatment;success;synergism;Technology;therapeutic target;Time;Transcend;wearable device;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PREP Project Narrative Our postbac research education program will continue to develop and train underrepresented minorities to acquire skills needed to succeed in Ph.D. programs in behavioral and biomedical Sciences and Engineering at top universities. The skills developed include training in interdisciplinary research, critical thinking, mentoring and advising, networking and presentation skills (writing and communication). These activities continue to positively impact the number of minorities who go on to receive PhDs and to subsequently pursue careers in biomedical or behavioral research, which is a major goal of the PHS.

PI_NAMEs: SMITH, EDWARD J (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Academia;Admission activity;aluminum sulfate;aspirate;Awareness;Behavioral;Behavioral Research;Behavioral Sciences;Biomedical Engineering;Biomedical Research;California;career;Climate;cohort;college;Communication;Complement;Computer Models;Critical Thinking;Development;Discipline;Doctor of Philosophy;Education;education research;Educational Activities;Engineering;Enrollment;experience;Exposure to;Faculty;flexibility;Funding;Genomics;Goals;graduate school;graduate student;Growth and Development function;Historically Black Colleges and Universities;Hour;improved;Industry;innovation;Institution;Interdisciplinary Study;Interview;Leadership;Learning;Lived experience;mathematical model;matriculation;meetings;Mentors;Mentorship;mid-career faculty;Minority;minority student;Modeling;National Institute of General Medical Sciences;Neurosciences;Oral;Outcome;outreach;Pathway interactions;pedagogy;peer coaching;Peer Review;Phase;Postbaccalaureate;Privatization;Process;Productivity;professor;programs;Puerto Rico;recruit;Research;Research Project Grants;Research Training;Rotation;Rural;Schedule;Science;Series;skill acquisition;skills;social;Standardization;Structure;student mentoring;Students;success;symposium;tool;Training;Training Programs;Underrepresented Minority;United States National Institutes of Health;Universities;Virginia;virtual;Waiting Lists;Woman;Writing

PROJECT_TITLE: Virginia Tech Postbaccalaureate Research Education Program (VT PREP)


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: EVANSTON

ORG_NAME: ENDEAVOR HEALTH CLINICAL OPERATIONS

PHR: Breastfeeding peer counseling (BPC) programs have proven effective at promoting social and economic equity in breastfeeding and reducing maternal and infant morbidity and mortality, but uptake of BPC programs in clinical settings (ci-BPC) has been limited. This study will fill a critical knowledge gap by evaluating the implementation of an effective ci-BPC program and determining essential program activities, relevant contextual factors, and patient, program, system, and societal costs that are pertinent to decision-makers considering the utilization of ci-BPC. The results of this study will provide critical information to enable the design, implementation, and uptake of ci-BPC to advance perinatal health equity.

PI_NAMEs: KEENAN-DEVLIN, LAUREN  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Optimizing utilization of lay health workers to address maternal and child health disparities: A Comprehensive Evaluation of a clinically integrated Breastfeeding Peer Counseling Program

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Telehealth

PROJECT_TERMS: Acceleration;adaptive intervention;Address;Adherence;Adolescent;Adult;Advanced Development;Agitation;AIDS prevention;Applications Grants;Area;Assessment tool;Behavior monitoring;Behavior Therapy;Cellular Phone;Clinical;Collection;Communities;Consultations;cost;Data;Decision Making;Development;Diagnosis;Diagnostic;digital;digital assessment;Digital biomarker;digital health;digital phenotyping;digital treatment;Doctor of Philosophy;dual diagnosis;Education;Educational Activities;Educational workshop;Effectiveness;Ethics;Etiology;Evaluation;evidence base;Evidence based treatment;Exercise;Experimental Designs;Faculty;Fostering;Funding;Goals;Grant;Health;health assessment;Heart Rate;improved;Individual;innovation;Intervention;intervention effect;Location;Measurement;media use;Mental Health;Mentors;Mentorship;Methods;Minority;Minority Groups;Minority Health Research;novel;Outcome;Outcome Study;Paper;Participant;personalized therapeutic;Persons;Pharmacotherapy;phenotypic data;physical conditioning;Physiologic Monitoring;Population;Population Heterogeneity;Postdoctoral Fellow;Privacy;Process;Process Assessment;Public Health;Publishing;recruit;Reduce health disparities;Relapse;Research;Research Personnel;Research Priority;Research Project Grants;Resource Sharing;Resources;Risk;Science;Services;Sleep disturbances;social contact;Specificity;Students;substance use;Substance Use Disorder;substance use treatment;success;Targeted Research;Technology;Therapeutic;Therapeutic Research;therapy design;therapy development;Time;Training;Treatment Protocols;Underrepresented Minority;usability;wearable sensor technology;webinar

PROJECT_TITLE: Treatment Development & Evaluation Core


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: SEKALY, RAFICK PIERRE (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;adaptive immune response;antiviral immunity;Berlin;Biological;biomarker identification;Bone Marrow Cell Transplantation;Cells;Cellular Immunity;Clinic;Clinical;cytokine;Development;Disease remission;Frequencies;Goals;HIV;HIV Infections;Human;Human Activities;Immune response;Immunity;Individual;Instruction;Interleukin-10;Intervention;Lymphoid Tissue;Macaca;Macaca mulatta;Maintenance;Molecular;Monitor;Morbidity - disease rate;mortality;Natural Immunity;novel strategies;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Play;preclinical trial;predictive marker;prevent;Regimen;restoration;Rhesus;Role;SIV;Testing;Therapeutic;Therapeutic Intervention;Tissues;Translating;Up-Regulation;Viral;Virus

PROJECT_TITLE: Harnessing IL-10 in cART treated SIV infected macaques to restore immunity and to eradicate HIV

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Aging;Nutrition;Osteoporosis

ORG_CITY: TOLEDO

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

PHR: This proposal will investigate mechanisms by which bone is integrated with regulation of energy metabolism, and its dysregulation with aging. It will characterize a protein, which is already used as a pharmacological target to treat diabetes for its novel function in regulation of osteocyte energy utilization and activities supporting bone remodeling, and regulation of systemic energy metabolism. This knowledge is critical for the future research in which this protein will be selectively targeted in order to develop a therapy which will simultaneously improve bone quality and energy metabolism in elderly.

PI_NAMEs: GRIFFIN, PATRICK ROBERT;LECKA-CZERNIK, BEATA ANNA (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Adipocytes;Affect;Age-Related Bone Loss;aged;Aging;aging population;Agonist;American;Applications Grants;Bioenergetics;bone;bone cell;Bone Formation Inhibition;bone loss;bone mass;bone metabolism;bone quality;Bone remodeling;Bone Resorption;C57BL/6 Mouse;Cell Physiology;Cells;Chronic Disease;Coculture Techniques;CRISPR/Cas technology;Diabetes Mellitus;Diagnosis;Disease;effective therapy;Elderly;Endocrine;Energy Metabolism;Enhancers;Exhibits;experimental study;Fracture;Genetic;Genetic Transcription;Homeostasis;Hormonal;Hyperglycemia;Impairment;improved;In Vitro;in vivo Model;inhibitor;insight;Knowledge;Lead;Maintenance;Metabolic Diseases;Metabolic dysfunction;Metabolism;Mitochondria;Molecular;mouse model;Mus;novel;Nuclear Receptors;Organ;Organ Culture Techniques;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;Osteoporosis;paracrine;Pathway interactions;pharmacologic;Physiologic calcification;Population;PPAR gamma;preference;Process;Production;programs;promoter;protein complex;Proteins;Proteomics;Quality of life;Regulation;Research;response;Role;rosiglitazone;Signal Transduction;skeletal;Skeleton;Testing;TNFSF11 gene;transcriptomics

PROJECT_TITLE: PPARG regulates osteocyte bioenergetics and function during aging


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Despite the negative drinking consequences associated with drinking, young adults continue to engage in risky alcohol consumption, and believe that negative consequences are both unlikely and not very negative. The proposed project will fill an important gap in the alcohol expectancies literature by examining how peoples’ thoughts about the positive and negative consequences of alcohol use change both looking back on prior drinking events and looking forward at future drinking events (e.g., alcohol expectancies) to understand how thoughts and beliefs about drinking change over the short term. Results from the proposed project will identify how past consequences and future expectancy likelihoods and valences change over the short term which may inform future prevention and intervention efforts relating to challenging drinking thoughts and beliefs.

PI_NAMEs: SCHULTZ, MEGAN  (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Address;Affect;alcohol consequences;Alcohol consumption;alcohol expectancy;alcohol related consequences;Back;Belief;Compensation;Complement;Complex;design;Development;drinking;drinking behavior;Ecological momentary assessment;Evaluation;Event;Expectancy;experience;Friendships;Future;Goals;Heavy Drinking;Individual;Intervention;Link;Literature;Longitudinal Studies;Manuscripts;Modeling;Nature;Negative Valence;Pacific Northwest;Participant;Perception;Performance;Persons;Positive Valence;Predisposition;Preparation;prevent;Prevention;Prevention Research;Process;rate of change;recruit;Reporting;Research;research data dissemination;response;Shapes;social cognitive theory;symposium;Testing;theories;Thinking;Time;Training;Universities;university student;unsafe driving;Update;Variant;willingness;Work;young adult

PROJECT_TITLE: How the short-term influence of drinking consequences shapes the development of expectancies: An event-level study


ORG_CITY: IRVINE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative The development of new chemical methods for organic synthesis is essential in the preparation of natural products and other bioactive molecules for preliminary biological studies, clinical trials, and production for market. Despite the advanced state of synthetic chemistry serious challenges remain. This proposal describes the development of new chemical reactions that will address one of these challenges, cross-electrophile coupling and cascade reactions that form tertiary stereogenic centers embedded in cyclopropanes and ring systems.

PI_NAMEs: JARVO, ELIZABETH REINHARDT (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Stereoselective Nickel-Catalyzed Coupling and Cascade Reactions

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative. Many neurodegenerative diseases originate due to dysregulated lysosomal Ca2+ levels in brain cells. Diagnosing and treating these diseases requires information about lysosomal Ca2+ homeostasis, particularly on the different mechanisms of lysosomal Ca2+ import and release. We propose to deploy a new Ca2+ reporter in an innovative genetic model we have developed in order to identify and study novel mechanisms of lysosomal Ca2+ homeostasis.

PI_NAMEs: KRISHNAN, YAMUNA  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Acidity;Affect;Alanine;Animals;Binding;Binding Sites;Biological Assay;brain cell;Caenorhabditis elegans;Calcium;Catalogs;Data;Defect;Diagnosis;Disease;Dyes;Endoplasmic Reticulum;Engineering;experimental study;Genes;Genetic;Genetic Models;Goals;Growth;Heavy Metals;Hepatocyte;Homeostasis;Homologous Gene;Human;Image;Impairment;innovation;insight;Ions;Knowledge;Laboratories;Lead;Lysosomes;Maps;Measures;Mediating;Metal Ion Binding;Metals;Methodology;Modeling;Molecular;molecular modeling;mutant;Mutation Analysis;Nematoda;Nervous System Disorder;Neurodegenerative Disorders;Normalcy;novel;Organelles;Organism;overexpression;PARK9 gene;Parkinson Disease;Pathway interactions;Phenotype;Proteins;quantitative imaging;Reporter;Reporting;risk variant;Saccharomyces cerevisiae;screening;success;Swelling;System;Testing;theories;uptake;vacuolar H+-ATPase;Variant;Whole Organism

PROJECT_TITLE: Calcium homeostasis in organelles

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Relevance to Public Health, Project Narrative Through this project we will create a Data Administration and Coordinating Center (DACC) for the NHGRI Impact of Genomic Variation and Function (IGVF), which promises to transform our understanding of the associations between genetic variation and phenotype. Our proposed DACC will serve as the primary administration, communication, outreach and data center for IGVF awardees and provide leadership for standards and processing pipeline implementation, and facilitate FAIR databases and software. Due to our cross-cutting and unparalleled technical expertise in data management, genomics, informatics, network analysis, and privacy-preserving application as well as our role leading a large data coordination center, managing, coordinating data and metadata, as well as creating gold standard knowledgebases, Stanford is in a strong position to serve as the IGVF DACC.

PI_NAMEs: CHERRY, J. MICHAEL (contact);GERSTEIN, MARK BENDER;HITZ, BENJAMIN

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: analysis pipeline;Biological;Biological Assay;biological research;Biomedical Research;Catalogs;Cells;Cellular Assay;cloud storage;Collaborations;Communication;Communities;Complex;complex data;Computer Analysis;computer infrastructure;Computer software;Computing Methodologies;Data;data analysis pipeline;data centers;Data Coordinating Center;data harmonization;data integration;data management;data modeling;data resource;Data Set;Data Sources;data submission;data warehouse;Databases;design;distributed data;Documentation;Electronic Mail;Elements;expectation;experimental study;FAIR principles;Feedback;functional genomics;Gene Expression;gene network;Genetic;Genetic Variation;genomic variation;Genomics;Goals;Graph;graph database;Human;Human Resources;improved;Individual;Informatics;innovation;knowledgebase;Laboratories;Leadership;Life;Machine Learning;Maps;meetings;Metadata;Methodology;Methods;Modeling;molecular phenotype;National Human Genome Research Institute;novel;online resource;Ontology;outreach;Participant;Pathway Analysis;Phenotype;Policies;Positioning Attribute;predictive modeling;privacy preservation;Procedures;Process;Protocols documentation;Public Health;Publications;Regulation;Reporting;Research;Research Personnel;Resources;Retrieval;Role;Sampling;Science;scientific organization;Selection Criteria;Semantics;service organization;Services;social media;Software Tools;Specific qualifier value;Standardization;Structure;Students;Technical Expertise;Techniques;Tissues;tool;Update;Variant;verification and validation;web services;webinar;Work;working group;Writing

PROJECT_TITLE: A Data and Administrative Coordinating Center for the Impact of Genomic Variation on Function Consortium


NIH_SPENDING_CATS: Brain Disorders;Dissemination and Implementation Research;Drug Abuse (NIDA only);Substance Misuse;Telehealth

PROJECT_TERMS: Acceleration;adaptive intervention;Adoption;Awareness;care systems;Caring;Case Study;Charge;Clinical;community college;Community Practice;Consensus;cost;Data;Diagnostic;digital;digital assessment;digital health;digital platform;digital treatment;Dissemination and Implementation;dissemination strategy;Doctor of Philosophy;dual diagnosis;Education;Educational workshop;effective therapy;Equity;Ethics;Evidence based treatment;Fostering;Funding;Goals;Grant;implementation barriers;implementation research;implementation science;improved;International;Knowledge;knowledge base;Measurement;Mental Health;Mentors;Mentorship;Methods;National Institute of Drug Abuse;next generation;Paper;Persons;physical conditioning;Population;Population Heterogeneity;Postdoctoral Fellow;pre-doctoral;Process;Public Health;Publications;Publishing;Research;Research Methodology;Research Personnel;Research Support;Resources;scale up;Science;Scientific Advances and Accomplishments;Services;skills;social media;Specific qualifier value;Students;Substance Use Disorder;substance use treatment;symposium;Technology;Therapeutic Research;Therapeutic Uses;therapy development;Training;Training Programs;Training Support;Translational Research;Underrepresented Minority;Underrepresented Populations;web site;Work

PROJECT_TITLE: Dissemination & Implementation Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Prevention;Rehabilitation;Sleep Research;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Cancer-related cognitive impairment is a major public health burden that affects up to 75% of breast cancer survivors. The ENHANCE trial has the potential to expand treatment options for this prevalent, debilitating condition and to advance scientific understanding of acupuncture and its effects on cognition and sleep. This knowledge will improve quality of life and promote healthy cognitive aging for millions of cancer survivors.

PI_NAMEs: MAO, JUN J (contact)

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: Acupuncture Therapy;Address;Affect;Animal Model;arm;attentional control;Biological Markers;Biometry;Brain-Derived Neurotrophic Factor;Breast Cancer Patient;Breast Cancer survivor;Breast Oncology;Cancer Center;Cancer Control;cancer prevention;Cancer Survivor;cancer-related cognitive impairment;chemotherapy;Chinese;Chinese Traditional Medicine;Clinical Trials;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive rehabilitation;Cognitive Therapy;cognitive training;Comorbid Insomnia;comparative effectiveness trial;Data;design;Discipline of Nursing;efficacious treatment;Etiology;Evaluation;evidence base;executive function;Exercise;experience;Grant;Hippocampus;improved;improvement on sleep;Individual;Intervention;Intervention Studies;Knowledge;Long-Term Effects;Longterm Follow-up;Malignant Neoplasms;Measures;Memory;Methodology;mindfulness;Modeling;multidisciplinary;Needles;Neurocognitive;Nonpharmacologic Therapy;novel;Patients;personalized medicine;Phenotype;Pilot Projects;primary endpoint;primary outcome;Process;programs;Public Health;Publishing;Quality of life;Randomized;recruit;Reporting;Research;response;Role;Sample Size;Science;Scientific Advances and Accomplishments;secondary analysis;secondary outcome;Serum;Severities;skills;Sleep;Sleep disturbances;Sleeplessness;symptom management;Symptoms;Techniques;Testing;Therapeutic;Time;treatment as usual;trial comparing;United States;verbal;Verbal Learning;Waiting Lists;Work;Yoga

PROJECT_TITLE: Effect and Mechanism of Acupuncture for Cancer-related Cognitive Impairment (ENHANCE)

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]