NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative To generate accurate movements, the brain benefits from learning sensorimotor associations that are stored as motor memories through the process of synaptic plasticity in the cerebellum. The inability to form and store accurate representations of these associations may result in movement disorders that impair the quality of life for many people. Therefore, the goal of this project is to identify the locations in the cerebellum where motor memories are stored for different types of learning and uncover the molecular and synaptic features that allow for a diversity of memories that vary in duration, magnitude, and direction.

PI_NAMEs: CHRISTIE, JASON M (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Adaptive Behaviors;Affect;Animals;Ataxia;awake;Behavior;Brain;Cell Physiology;Cells;Cerebellar Cortex;Cerebellum;Data;Dependence;deviant;Dystonia;Electrophysiology (science);Equilibrium;Excitatory Synapse;Exhibits;experience;Eye Movements;Fiber;Fire - disasters;Future;gamma-Aminobutyric Acid;Goals;Impairment;In Vitro;in vivo;Inferior;innovation;insight;Instruction;interdisciplinary approach;Interneurons;Knowledge;learned behavior;Learning;Link;Location;Long-Term Depression;Measurement;Measures;Mediating;Memory;memory encoding;memory process;memory recall;Modeling;Modification;Molecular;mossy fiber;Motor;motor behavior;motor control;motor disorder;motor learning;Movement;Movement Disorders;Mus;N-Methyl-D-Aspartate Receptors;Nervous System Physiology;neural correlate;novel;Olives - dietary;optogenetics;Outcome;Output;Pathology;Pathway interactions;Pattern;Persons;Play;postsynaptic;Predisposition;Preparation;Process;Property;Purkinje Cells;Quality of life;receptor-mediated signaling;response;Role;Signal Transduction;Site;Slice;Stimulus;Structure of purkinje fibers;Synapses;Synaptic plasticity;Testing;Training;Transgenic Mice;vestibulo-ocular reflex;Work

PROJECT_TITLE: Motor Memory Storage in the Cerebellum

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Increasing competition for scarce research dollars and other hardships facing those in academic medicine, as well as the lure of private practice, discourage trainees from careers in digestive diseases-related research. The overall goal of this T32 training program is to seek, nurture and mentor talented pre- and postdoctoral trainees committed to research or leadership positions in academia, federal agencies or industry, and provide them with successful role models and the tools needed to persevere and succeed in this harsh environment. To accomplish these goals, our multidisciplinary faculty offers an integrated, individualized curriculum for training in basic or clinical & translational digestive diseases-related science in a diverse and resource-rich research environment with strong institutional support.

PI_NAMEs: RAUFMAN, JEAN-PIERRE  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TITLE: Research Training in Gastroenterology and Hepatology


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: PARKTOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: WITS HEALTH CONSORTIUM (PTY), LTD

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will provide a framework to use routinely collected South African laboratory data to track tuberculosis (TB) patients through time and space, incorporating HIV data. This will allow us to define the TB care cascade nationally and by facility (clinic/hospital), incorporating patients’ movements, thus enabling the targeting of these locations with locally appropriate interventions. We will also be able to evaluate the impact of HIV treatment scale-up and introduction of new TB diagnostics on TB morbidity and mortality – directly relevant to the NIH’s mission of reducing morbidity and mortality due to tuberculosis.

PI_NAMEs: JENKINS, HELEN E.;SCOTT, LESLEY  (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Accounting;Address;Aftercare;Algorithms;Area;Benchmarking;burden of illness;Caring;Categories;Cessation of life;Clinic;Clinics and Hospitals;cohort;Communicable Diseases;Country;Data;Data Set;Data Sources;Databases;design;Diagnosis;Diagnostic;diagnostic algorithm;Disease;Disease Progression;disorder risk;DNA;Drug resistance in tuberculosis;Epidemic;Evaluation;Financial cost;global health;Goals;Health;Health Professional;HIV;HIV diagnosis;HIV/TB;Human immunodeficiency virus test;improved;Incidence;Income;Individual;Infection;infection rate;Infrastructure;innovation;Intervention;Knowledge;Laboratories;Link;Location;longitudinal care;Longitudinal cohort;Maps;melting;Methods;migration;Mission;Modeling;Moldova;Molecular;Monitor;Morbidity - disease rate;mortality;Movement;Mycobacterium tuberculosis;Natural History;Nature;novel;novel diagnostics;novel therapeutics;Outcome;Patients;Pattern;Persons;Policies;Policy Maker;Poliomyelitis;Population;Prevalence;prevent;programs;Province;Public Health;Records;Relapse;Reporting;Research;Risk Factors;scale up;Services;Smallpox;South Africa;South African;surveillance data;Temperature;Test Result;Testing;testing services;Time;transmission process;treatment duration;Tuberculosis;tuberculosis diagnostics;tuberculosis treatment;United States National Institutes of Health;Variant;Viral;Work;World Health Organization

PROJECT_TITLE: Evaluating the tuberculosis epidemic in South Africa using a novel ten-year cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-W(50)R]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Relevance. c-Myc is a central driver of cancers and is a validated drug target, however, no MYC-targeted therapeutic is available despite over 35 years of pursuit because the MYC protein is considered “undruggable”. The c-Myc promoter G-quadruplex represents a novel target for c-Myc inhibition; nucleolin is involved in the c-Myc regulation by G4-targeted compounds and the nucleolin-MycG4 complex could serve as a more specific target for drug development. If successful, our study will have important implications because the design of G4-targeted drugs to date has been focused solely on MycG4 DNA.

PI_NAMEs: YANG, DANZHOU  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Affect;Affinity;Antineoplastic Agents;Binding;Binding Proteins;Binding Sites;Biochemical;Bioinformatics;Biological Assay;Biophysics;c-myc Genes;C-terminal;cancer cell;Cells;Chemicals;ChIP-seq;Chromatin;chromatin immunoprecipitation;Collaborations;Complex;Computer Models;Crystallography;Data;design;Disease;DNA;drug development;Drug Targeting;Elements;EMSA;Enzyme-Linked Immunosorbent Assay;experience;experimental study;Fluorescence;Fluorescence Resonance Energy Transfer;G-Quartets;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genomics;Global Change;Hela Cells;Human;In Vitro;in vivo;Libraries;Ligands;Malignant Neoplasms;Methods;Molecular;Molecular Structure;Mutation;MYC Family Protein;N-terminal;NMR Spectroscopy;novel;Nuclear Extract;nucleolin;Oncogenes;overexpression;Play;promoter;Promoter Regions;Proteins;Regulation;Repression;Research;response;RNA;RNA Recognition Motif;Role;screening;small molecule;Specificity;Structure;targeted treatment;Tertiary Protein Structure;transcriptome sequencing;X-Ray Crystallography

PROJECT_TITLE: Nucleolin recognition of MYC promoter G-quadruplex and its role in MYC regulation by MycG4-ligands

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

ORG_STATE: NY

PHR: The objective of the Research Institute Rheumatology Training Program at Hospital for Special Surgery (HSS) is to train (1) outstanding physicians to become independent investigators; (2) Ph.D. scientists in rheumatic disease research enable multidisciplinary research to improve clinical outcomes and advance patient care; and (3) attract Ph.D. and MD-PhD. candidates into rheumatology research. The unique environment at HSS, focused on study of and care for patients with autoimmune and musculoskeletal diseases, is the setting for comprehensive training of the next generation of academic leaders who ultimately will impact the lives of patients with rheumatic diseases.

PI_NAMEs: PERNIS, ALESSANDRA B;SALMON, JANE E (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: HSS Research Institute Rheumatology Training


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Defects in cellular responses to DNA double-strand breaks can lead to mutations, deletions or other alterations in the genome and underlie many diseases. Our proposed studies will determine the regulation of linkage- specific ubiquitin modification on damaged chromatin and the underlying mechanism for DNA repair and transcription inhibition at DSBs. Our findings should provide novel insights into the understanding of the complex DNA response network that protects genome integrity, which is essential for translation into tools and treatment to improve human health.

PI_NAMEs: WANG, BIN  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: ataxia telangiectasia mutated protein;BRCA1 gene;Cells;Characteristics;Chromatin;Complex;cytotoxic;Defect;design;Detection;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Gene;Event;Failure;gene repression;Genetic Transcription;Genome;genome integrity;Genome Stability;Goals;Health;Histone H2A;Human;improved;Individual;insight;Ionizing radiation;Lesion;Link;Lysine;Mediating;Methionine;Modeling;Modification;Monoubiquitination;Mutation;N-terminal;novel;p53-binding protein 1;Pathway interactions;Play;Polyubiquitin;Polyubiquitination;Post-Translational Protein Processing;prevent;Production;Proteins;Reader;recruit;Regulation;repaired;response;restriction enzyme;Role;Signal Transduction;Site;System;tool;Transcript;Translations;Ubiquitin;Ubiquitination

PROJECT_TITLE: Coordination of DNA repair and transcription by ubiquitin modification at DNA double strand breaks

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Opioids;Pain Research;Patient Safety;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Injury is a leading cause of death and disability of older adults in the United States and older adults account for one-third of 911 calls for injury, but little is known about the health impact of emergency medical services (EMS) care for this population. This application will support a new investigator who aspires to a research career focused EMS and surgical care of injured older adults, especially the impact of prehospital EMS care on long-term health and functional status following injury diagnosis. The award will enable the investigator to develop knowledge and skills necessary to conduct independent research investigating patterns of care and health outcomes for injured older adults, which will lead to more effective treatment of this population.

PI_NAMEs: JARMAN, MOLLY PRICE (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: 911 call;Absence of pain sensation;Accounting;Acute;Acute Pain;Acute pain management;Address;advanced analytics;Advanced Development;Aging;aging process;American;analytical method;Anatomy;assault;Award;Brain;care systems;career;Caring;Cause of Death;Cessation of life;Characteristics;chronic pain;college;Country;Data Linkages;Delirium;Dementia;dementia risk;demographics;Destinations;Diagnosis;disability;economic evaluation;effective therapy;Effectiveness;Elderly;Emergency Department Physician;Emergency medical service;Exertion;Expenditure;experience;Face;falls;Fracture;frailty;Freedom;functional improvement;functional status;Funding;Geographic Locations;Geography;Guidelines;hazard;Health;Health Service Area;Health Status;Health system;Home;Hospital Administration;Hospitals;Hour;human old age (65+);Human Resources;Impaired cognition;improved;Incidence;Infrastructure;injured;Injury;injury recovery;Injury Severity Score;inpatient service;instructor;Intensive Care Units;Intervention;Investments;Knowledge;Length of Stay;Life;Limb structure;Literature;Medical emergency;Medicare;Medicare claim;Mentored Research Scientist Development Award;Mentorship;Methodology;Methods;Modeling;Mollies;mortality;Multiple Trauma;Narcotics;National Institute on Aging;older adult;Older Population;Operative Surgical Procedures;Opiate Addiction;Opioid;Opioid Analgesics;opioid use;optimal treatments;Outcome;Pain;Pain management;pain relief;Pathway interactions;Patient Care;Patients;Patterns of Care;Pharmaceutical Preparations;Physiological;Population;practical application;Practice Guidelines;Pre-hospitalization care;prevent;Probability;Protocols documentation;Provider;psychosocial;Public Health;Recommendation;Records;Recovery;Recovery of Function;Research;Research Personnel;Resources;Risk;Risk Reduction;rural area;Self-Injurious Behavior;service organization;service providers;severe injury;Severities;skills;Statistical Methods;Structure;Time;Time Management;Training;Transportation;Trauma;trauma care;trauma centers;Traumatic injury;treatment services;United States;urban area;Variant;Vehicle crash;Wages;Woman;women patients;Work

PROJECT_TITLE: Health Impacts of Prehospital Pain Management for Injured Older Adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Mental Health;Prevention;Rare Diseases;Rehabilitation

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Oral and oropharyngeal cancer survivors carry a high symptom burden that results in many self care requirements that can be overwhelming complex difficult to manage and can result in compromised quality of life unmet needs and low participation in self-care. There are no empirically based interventions to enhance skills and confidence to manage oral cancer survivors self care. This study proposes to evaluate a promising online intervention called Empowered Survivor or ES for short and evaluate its impact on self efficacy in managing care preparedness for managing survivorship and health related quality of life as well as engagement in several key self-care behaviors. Should ES prove efficacious it will serve as a model of care and advance both science and practice for cancer survivors particularly those who reside in the community.

PI_NAMEs: MANNE, SHARON L (contact)

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Address;Adherence;advanced disease;Affect;Age;Alcohols;American Cancer Society;Appearance;Appointment;Attention;Behavior;California;Cancer Intervention;Cancer Survivor;cancer type;Caring;Cessation of life;clinical research site;Clinical Trials;Communities;community setting;comorbidity;Complex;Deglutition;Dental Care;Dentists;design;Deterioration;Diagnosis;Disease;drinking;Early Diagnosis;Electronic Mail;empowerment;Ethnic Origin;Exercise;feasibility testing;Feedback;follow-up;Free Will;Fright;future implementation;General Population;Goals;Head and neck structure;Head Movements;health related quality of life;Human Papillomavirus;improved;innovation;Intervention;Late Effects;Lesion;Life;Location;Long Term Survivorship;Long-Term Effects;Longterm Follow-up;loss of function;Maintenance;malignant mouth neoplasm;Malignant Neoplasms;malignant oropharynx neoplasm;Managed Care;Measures;Mediation;Mediator;Medical;Modeling;muscle strength;National Cancer Institute;Neck;neoplasm registry;New Jersey;nutrition;Oncologist;online delivery;online intervention;Oral;oral care;Oral cavity;Oral health;Participant;Patients;Performance;physical therapist;Pilot Projects;Positron-Emission Tomography;preservation;Prevalence;prevent;primary outcome;process evaluation;psychologic;psychosocial;Quality of life;Race;Randomized;Readiness;Recommendation;recruit;Recurrence;Regimen;Reporting;Role;routine care;Science;secondary outcome;Self Care;Self Efficacy;Self Management;sex;Shoulder;skills;smoking cessation;Speech;Structure;Surgeon;Survivors;survivorship;Symptom Burden;symptom management;Symptoms;Taste Perception;United States;Xerostomia

PROJECT_TITLE: Enhancing Self Care Among Oral Cancer Survivors: The Empowered Survivor Trial

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Enhancer hijacking events have been reported in the pathogenesis of cancer and other diseases. However, there has been no computational method to systematically detect such events genome-wide. Here we propose a series of algorithms to detect enhancer hijacking events in Hi-C data and will perform functional validation experiments to evaluate our predictions.

PI_NAMEs: YUE, FENG  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;Acute Myelocytic Leukemia;Acute T Cell Leukemia;Algorithms;ATAC-seq;cancer cell;Cancer cell line;cancer genome;cancer genomics;cancer type;Cell Line;cell motility;Cell Proliferation;cell type;Cells;ChIP-seq;Chromatin;Chromosome 3;chromosome fusion;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Communities;Computer software;Computing Methodologies;Copy Number Polymorphism;CRISPR/Cas technology;Data;Data Set;Disease;disease phenotype;Distal;Enhancers;Environment;Epigenetic Process;epigenomics;Event;EVI1 gene;experimental study;Gene Expression Regulation;Genes;Genetic;Genome;genome-wide;Genomics;Hi-C;Human Cell Line;human disease;Human Genome;K-562;Knock-out;Limb structure;malformation;Malignant Neoplasms;mammalian genome;Maps;Measures;Methods;Modeling;novel;Oncogenes;Output;Pathogenesis;Patients;Phenotype;promoter;Proto-Oncogenes;Publishing;Regulatory Element;Reporting;Resolution;Resources;restraint;Role;Sampling;Series;software development;Source;Structure;Systematic Bias;Testing;transcriptome sequencing;tumor progression;Untranslated RNA;Up-Regulation;Validation;Variant

PROJECT_TITLE: Computational methods to identify neo-TADs and enhancer-hijacking in rearranged genomes

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Capitalizing on UCLA’s unique strengths, I propose to create a new and cutting-edge Center of Aging and Mitochondrial Health, with an emphasis on Alzheimer’s disease. This will foster research activities of faculty across multiple disciplines, departments and schools at UCLA. As a collaborative effort, we will also develop new courses and educational activities on aging, aging and mitochondrial health, and Alzheimer’s disease, and mentor graduate students, postdoctoral scholars, medical fellows and junior faculty with a goal to enhance aging research capacity and increase the number of future researchers and educators in aging research including Alzheimer’s disease.

PI_NAMEs: GUO, MING  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Address;Age;age-related disease;Aging;aging related;aging related disease;Alzheimer's Disease;Alzheimer's disease risk;Area;Award;Biology;career;career development;Clinical;Collaborations;Communities;Databases;Dedications;Dementia;design;Development;Diabetes Mellitus;Discipline;Education;Educational Activities;Educational Curriculum;Educational workshop;Elderly;Extramural Activities;Faculty;Fostering;Foundations;Funding;Future;Gerontology;Goals;graduate student;Grant;Health;Heart Diseases;human old age (65+);Impaired cognition;Institution;interest;International;Leadership;Learning;Libraries;Malignant Neoplasms;Medical;meetings;member;Memory Disorders;Mentors;Mentorship;Mitochondria;mitochondrial dysfunction;Muscle;Myocardial dysfunction;Neurodegenerative Disorders;new technology;next generation;normal aging;Online Systems;Parkinson Disease;Persons;Physicians;Population;post-doctoral training;Postdoctoral Fellow;Prevalence;programs;recruit;Recurrence;Research;Research Activity;research and development;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Resources;Role;sarcopenia;Scholars Program;Schools;Scientist;Series;Specialist;success;symposium;Talents;Teacher Professional Development;Technology;Training;translational medicine;Travel;visiting scholar;web site;Work

PROJECT_TITLE: Academic Career Leadership Award in Aging

STUDY_SECTION_NAME: Biological Aging Study Section[NIA-B]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology;Nutrition

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Low amounts of vitamin K in the diet are converted to an activated form in the body that is used for blood clotting by two proteins called VKORC1 and the carboxylase. VKORC1 is inhibited by the drug warfarin, which is used by millions of people worldwide to control blood clotting, for example with mechanical heart valves, while the carboxylase modifies vitamin K-dependent proteins to activate them for roles in blood coagulation, bone development, cell growth and embryonic development. Determining how VKORC1 and the carboxylase function has important ramifications for understanding these aspects of human health and producing activated vitamin K-dependent proteins as potential therapeutic drugs.

PI_NAMEs: BERKNER, KATHLEEN LUCILE (contact);RUNGE, KURT W

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Affinity Chromatography;Anticoagulants;Apoptosis;Artificial Heart;Binding;Biological;Biological Assay;Blood coagulation;Blood Coagulation Factor;Bone Development;calcification;Calcium Binding;carboxylate;carboxylation;cell growth;Cell Line;Cells;Complex;CRISPR/Cas technology;Data;Defect;Diet;dietary;dimer;Dimerization;Disease;Dose;Drug usage;Embryonic Development;Epoxy Compounds;Excretory function;Extrahepatic;Functional disorder;gamma-glutamyl carboxylase;Growth;Growth and Development function;Health;Heart Valves;Hemorrhage;Hemostatic Agents;Hemostatic function;Human;Hydroquinones;in vivo;Inflammation;Ingestion;Mammalian Cell;Mediating;Metabolism;Modeling;Monitor;Mus;mutant;mutant mouse model;Mutation;oxidation;Oxidoreductase;paralogous gene;Persons;Pharmaceutical Preparations;Physiology;Platelet Activation;Play;Production;protein activation;protein complex;protein protein interaction;Proteins;Quinone Reductases;Quinones;Reaction;Recycling;reduced vitamin K;Regulation;Resistance;Role;Signal Transduction;Testing;Therapeutic;Tissues;Ubiquitin;virtual;Vitamin K;Vitamin K 2;vitamin K1 oxide;Warfarin;Yeasts

PROJECT_TITLE: Mechanisms controlling the efficiency of hemostatic vitamin K-dependent protein activation

STUDY_SECTION: HT

STUDY_SECTION_NAME: Hemostasis and Thrombosis Study Section.  Committee was terminated on 11/30/2020. [HT]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE The proposed work will contribute to our knowledge about the neural, cognitive, and computational mechanisms involved in human action control. This research will help determine which specific mechanisms are impacted in motor disorders and help identify new targets for therapy. Isolating specific mechanisms will improve our ability to treat and potentially cure disorders such as Parkinson’s disease, dystonia, and stroke.

PI_NAMEs: GREENHOUSE, IAN  (contact)

PROJECT_TERMS: Address;Agonist;Anatomy;Animals;Behavior Control;Behavioral;behavioral impairment;Brain;Butyric Acids;Chemicals;Clinical Research;Cognitive;cognitive process;Data;Dimensions;Disease;Dystonia;Electromyography;Etiology;Evoked Potentials;Exhibits;experimental study;Future;gamma-Aminobutyric Acid;Ganglia;goal oriented behavior;Goals;Grain;Human;Impairment;improved;Individual;Individual Differences;Influentials;innovation;Knowledge;Laboratories;Link;Magnetic Resonance Spectroscopy;Maps;Measurement;Measures;Modeling;Motor;Motor Cortex;motor disorder;motor symptom;Muscle;neural;neurochemistry;Neurocognitive;Neurons;Neurotransmitters;new therapeutic target;Noise;noninvasive brain stimulation;novel;novel marker;operation;Output;Parkinson Disease;Pathway interactions;Pattern;Physiological;Population;Preparation;Property;Publishing;recruit;Research;response;Rest;Role;sensory cortex;sensory system;Shapes;Signal Transduction;Stroke;Symptoms;System;Task Performances;Techniques;Testing;Therapeutic Intervention;Transcranial magnetic stimulation;Work

PROJECT_TITLE: Computational roles of inhibition in human action control

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Overall: Narrative The application of high-content immune profiling tools has revolutionized our ability to decode disease etiology and processes. This Human Immune Project Consortium, Maternal ‘Omics to Maximize Immunity (MOMi), seeks to use a multi-OMICs approach to decode the unique nature of the immune system that evolves across gestation. The Projects will generate foundational data to guide rational design of customized vaccines that optimize both maternal and neonatal health.

PI_NAMEs: EDLOW, ANDREA GOLDBERG;LAUFFENBURGER, DOUGLAS A (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 2019-nCoV;Allografting;Atlases;Autoimmune;Birth;cell type;Clinical;Communicable Diseases;Communities;COVID-19 pandemic;COVID-19 severity;Custom;Data;Data Analyses;data management;Data Set;density;Development;Disease;Ensure;Etiology;Fertility;Fertilization;fetal;Fetal health;Fetus;Genetic Transcription;Global Awareness;Growth;health of the mother;Human;Immune;Immune response;Immune system;Immune Tolerance;Immunity;Immunologics;Immunology;implantation;improved;in vivo;Individual;Infection;Inflammation;Intervention;Invaded;Knowledge;Lactation;Maternal Health;maternal immune system;maternal vaccination;Maternal-fetal medicine;Maternally-Acquired Immunity;metabolomics;Metagenomics;Mothers;multidisciplinary;multiple omics;Nature;neonatal health;Newborn Infant;novel;novel therapeutics;novel vaccines;Organ;pathogen;Phase;Play;Population;predictive marker;Pregnancy;pregnancy health;pregnant;Pregnant Women;Process;prophylactic;Proteomics;Race;rational design;Recording of previous events;Research Personnel;Role;Secondary Immunization;Shapes;success;System;Systems Biology;targeted treatment;Technology;Time;Tissues;tool;Vaccination;vaccination strategy;vaccine immunogenicity;vaccine platform;vaccine trial;vaccine-induced immunity;Vaccines;vaccinology;Work

PROJECT_TITLE: Maternal Omics to Maximize Immunity


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pregnancy;Prevention;Vaccine Related

PI_NAMEs: LAUFFENBURGER, DOUGLAS A (contact)

PROJECT_TERMS: Accountability;Affect;Agreement;Atlases;Autoimmune Diseases;Clinical;Clinical Management;cohesion;Collaborations;Communication;conflict resolution;COVID-19 pandemic;COVID-19 vaccine;Data;Data Analyses;data dissemination;data integration;data management;Data Set;data sharing;design;Development;digital;Ensure;Epidemic;Evolution;Exclusion;Feedback;fetal;Goals;Immune;Immune response;Immunity;Immunologic Surveillance;Immunologics;Immunology;immunosuppressed;Infant;Infection;Influenza;innovation;Investigation;Leadership;Legal;Link;Maternal-fetal medicine;Measures;Mentorship;Nature;novel therapeutics;novel vaccines;outreach;Performance;Pertussis;Play;Population;Predisposition;Pregnancy;Pregnant Women;Privatization;Program Evaluation;programs;Progress Reports;Recording of previous events;Research Personnel;Resources;Role;Running;Safety;sample collection;Sampling;Shapes;Site Visit;success;Systems Biology;timeline;tool;Training Support;Translating;United States National Institutes of Health;Vaccination;Vaccine Design;vaccine development;vaccine immunogenicity;vaccine response;vaccine strategy;vaccine trial;Visit;Vulnerable Populations;Woman;Work;ZIKA

PROJECT_TITLE: MOMI Administrative Core


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Stroke is the leading cause of disability in the United States, leaving a substantial number of survivors with permanent weakness. Neuromodulation of sensorimotor areas using physiologically targeted low-frequency stimulation is an innovative new direction to facilitate recovery of motor function. Our proposal seeks to optimize stimulation parameters as well as to develop electrophysiological makers of network function that delineate underlying mechanisms of action.

PI_NAMEs: GANGULY, KARUNESH  (contact);MORECRAFT, ROBERT J;MORRISON, JOHN H

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Affect;Animals;Area;Brain;Chronic;Data;design;dimension reduction;disability;Distant;Electric Stimulation;Electrophysiology (science);Engineering;Fingers;Frequencies;Generations;Goals;grasp;Hand;hand dysfunction;Human;improved;in vivo;Injury;innovation;Lesion;Link;Medicine;Methods;Motor;Motor Cortex;Motor disability;motor function recovery;motor impairment;motor recovery;Motor Skills;Movement;Nature;network models;neural;neural network;Neurons;neurophysiology;neuroregulation;Neurosciences;nonhuman primate;novel;Performance;Phase;Physiological;Population Dynamics;post stroke;Primates;Process;Randomized;Rattus;Recovery;Research;Residual state;Sensory;sensory cortex;skills;Somatosensory Cortex;Speed;stereotypy;Stroke;stroke model;stroke patient;stroke survivor;Survivors;System;Techniques;Testing;Therapeutic;therapeutic target;Training;United States;Upper Extremity;Work

PROJECT_TITLE: Modulating Low-Frequency Cortical Population Dynamics to Augment Motor Function After Stroke

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pneumonia and Influenza;Pregnancy;Prevention;Vaccine Related;Women's Health Research

PI_NAMEs: EDLOW, ANDREA GOLDBERG (contact)

PROJECT_TERMS: 2019-nCoV;adaptive immune response;adaptive immunity;Address;Advocacy;Allogenic;attributable risk;biobank;Biological Specimen Banks;Blood;Blood Banks;Blood specimen;Body mass index;Catalogs;Clinical;Clinical Data;clinical phenotype;clinically relevant;cohort;Collection;COVID-19;COVID-19 vaccination;COVID-19 vaccine;Data;Data Analyses;data management;Databases;Diabetes Mellitus;Diphtheria;Enrollment;ethnic diversity;Feces;fetal;Fetal health;Fetus;flu;Future;Gestational Age;Goals;Grant;Hypertension;Immune;immune health;Immunity;Immunoglobulin G;Immunologics;Individual;Influenza;Influenza A Virus, H1N1 Subtype;Influenza vaccination;Infrastructure;Innate Immune Response;Knowledge;Lead;longitudinal analysis;Maternal antibody;Maternal Health;maternal morbidity;Maternal Mortality;maternal vaccination;Maternally-Acquired Immunity;Metadata;Mothers;Natural Immunity;Nature;neonate;pandemic disease;Participant;Pathogenicity;Peripheral Blood Mononuclear Cell;Pertussis;Phenotype;placental transfer;Plasma;Pregnancy;pregnancy disorder;Pregnancy Trimesters;pregnant;prepregnancy;prevent;Prospective cohort;racial diversity;Recommendation;Research;Research Personnel;sample collection;Sampling;SARS-CoV-2 infection;seasonal influenza;Serum;Specimen;Stimulus;Tetanus;Therapeutic;Third Pregnancy Trimester;Tissue Banks;Tissue Sample;Vaccination;Vaccines;Virus Diseases;Work

PROJECT_TITLE: MOMI Clinical Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Maternal Health;Microbiome;Pediatric;Pneumonia and Influenza;Pregnancy;Prevention;Vaccine Related;Women's Health Research

PHR: Project 1: Narrative Project 1 leverages current clinical standards of maternal vaccination with novel COVID-19 vaccines, and routine vaccines against influenza and pertussis, to decode the rules of maternal immunity across gestation in normal pregnancy and in response to maternal vaccination. Mapping the Pregnancy Immune Atlas will provide key data to protect mothers and neonates from existing and emerging pathogens.

PROJECT_TERMS: adaptive immune response;Address;Adenoviruses;Adjuvant;Age;antibody transfer;Antigens;Area;Atlases;attributable risk;Biological Assay;Body mass index;booster vaccine;Cell Separation;cell type;Cells;Cellular Assay;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Child;Chromatin;Clinical;cohort;Collaborations;Complex;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;Data;Data Analyses;data integration;data management;Decidua Basalis;Disease;early pregnancy;emerging pathogen;Enrollment;Ensure;Equilibrium;experimental study;Fc Receptor;Feces;fetal;Future;Goals;gut microbiome;healthy pregnancy;high dimensionality;High-Throughput Nucleotide Sequencing;Human;Immune;Immune response;Immune system;Immune Tolerance;Immunity;Immunologics;Immunology;In Vitro;in vivo;Infant;Infection;Inflammation;Influenza;influenza virus vaccine;Infrastructure;Innate Immune Response;insight;Knowledge;Maps;maternal immune system;Maternal Mortality;maternal vaccination;Maternally-Acquired Immunity;Messenger RNA;Metabolic Diseases;metabolome;metabolomics;metagenomic sequencing;Metagenomics;microbial;microbiome;Mothers;multidisciplinary;multiple omics;neonate;next generation;novel;pandemic disease;pathogen;Peripheral Blood Mononuclear Cell;Pertussis;Pertussis Vaccine;Placenta;placental transfer;Plasma;Population;Pregnancy;Pregnancy Trimesters;Pregnant Women;Proliferating;prospective;Proteins;Proteome;Proteomics;receptor expression;Recording of previous events;Research Project Grants;Resolution;response;Sampling;SARS-CoV-2 negative;sex;Shapes;Shotguns;single-cell RNA sequencing;Systems Biology;Therapeutic;therapeutic development;Time;transcriptome;Transposase;Vaccinated;Vaccination;Vaccine Design;vaccine development;vaccine platform;vaccine response;vaccine strategy;Vaccines;Woman;Work

PROJECT_TITLE: Research Project 1 - The pregnancy ImmunOME


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pediatric;Pneumonia and Influenza;Pregnancy;Prevention;Vaccine Related;Women's Health Research

PHR: Project 2: Narrative  Project 2 seeks to utilize the unprecedented roll out of novel COVID vaccine platforms and routine vaccines  (influenza and pertussis) to define the impact of pregnancy on shaping vaccine-induced immunity, providing an  opportunity to chart the Pregnant Immune Atlas.

PI_NAMEs: JUELG, BORIS DOMINIK (contact)

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Adenovirus Vector;Adjuvant;Affect;Allografting;Anti-Inflammatory Agents;Antibodies;Antibody titer measurement;antibody transfer;Antigens;Atlases;Awareness;B-Lymphocytes;Biochemical;Birth;booster vaccine;Case Fatality Rates;Cellular Assay;Cessation of life;Chronology;Clinical;Communicable Diseases;comorbidity;COVID-19 pandemic;COVID-19 vaccine;Data;Data Analyses;design;Disease;Eligibility Determination;Emergency Situation;experience;fetal;Fetal Growth;Fetus;Future;Genetic;Growth;Health Personnel;hemodynamics;Human Milk;Immune;immune function;immune reconstitution;Immune response;Immunity;Immunization;Immunize;immunogenic;Immunologics;Immunology;implantation;Infant;Infection;infection risk;Inflammation;Inflammatory;Influenza;Influenza A Virus, H1N1 Subtype;Link;Maps;Maternal-fetal medicine;Messenger RNA;Morbidity - disease rate;mortality;Mothers;neonate;Newborn Infant;next generation;novel;novel vaccines;pandemic disease;Pertussis;Phase;phase III trial;Phenotype;Placenta;Placentation;Population;Predisposition;Pregnancy;Pregnancy Trimesters;pregnant;Pregnant Women;Property;Proteins;Race;rational design;Recommendation;Recording of previous events;Research Project Grants;respiratory;response;RNA vaccine;Safety;Sampling;Serology;Shapes;Specialist;success;Syndrome;System;T cell response;T-Lymphocyte;Therapeutic;therapy design;tool;transcriptome;Vaccination;Vaccine Design;vaccine distribution;vaccine platform;vaccine response;vaccine safety;vaccine strategy;vaccine-induced antibodies;vaccine-induced immunity;Vaccines;Viral;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Research Project 2 The pregnancy AdaptOME


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breastfeeding, Lactation and Breast Milk;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Data Science;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Maternal Health;Networking and Information Technology R&D (NITRD);Pregnancy;Prevention;Vaccine Related;Women's Health Research

PROJECT_TERMS: 2019-nCoV;Algorithms;Allografting;Anti-Inflammatory Agents;Atlases;Biological;Biology;Categories;cell type;Chronology;Clinical;Cluster Analysis;Communicable Diseases;complex data;Computer Analysis;computer framework;Computer Models;computer science;COVID-19 pandemic;Custom;Data;Data Analyses;data integration;data management;Data Set;Development;differential expression;Discipline;Disease;diverse data;Engineering;Equilibrium;Etiology;fetal;Global Awareness;Goals;Growth;heterogenous data;Immune;Immune response;Immune system;Immunity;Immunologics;Immunology;Immunosuppression;implantation;improved;in vivo;Individual;Infection;Infertility;Inflammatory;insight;Intervention;Intuition;Investigation;Lactation;Machine Learning;Maternal Health;maternal vaccination;Maternal-fetal medicine;Maternally-Acquired Immunity;Mathematical Biology;Mathematics;Measurement;Measures;Methods;Modeling;multidisciplinary;multiple omics;Nature;neonatal health;Newborn Infant;novel;novel strategies;novel therapeutics;novel vaccines;operation;Organ;pathogen;predicting response;Pregnancy;Pregnancy Trimesters;pregnant;Process;programs;Property;prophylactic;Publications;Recording of previous events;Research Personnel;Sampling;Shapes;Statistical Data Interpretation;System;Systems Biology;Techniques;Time;tool;Vaccination;vaccine platform;vaccine-induced immunity;Vaccines;vaccinology;Woman;Work

PROJECT_TITLE: MOMI Data Management


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: American Indian or Alaska Native;Breastfeeding, Lactation and Breast Milk;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Lung;Neonatal Respiratory Distress;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: The success of a multicenter network depends on contributions and collaborations of its member centers and investigators. The UNM team brings years of experience with multicenter clinical trials, demonstrated leadership, specific expertise in outcomes research, and a unique concentration of underrepresented populations to support the continuing success of the Neonatal Research Network.

PI_NAMEs: FULLER, JANELL  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: 6 year old;Adrenal Glands;Adrenal hormone preparation;Alaska Native;Area;behavioral outcome;Benefits and Risks;Biological Assay;cardiovascular insufficiency;Cardiovascular Physiology;Cardiovascular system;Certification;Child;Childhood;Clinical;clinical care;clinical practice;Clinical Research;Clinical Trials Network;cohort;Collaborations;Communication;Consent;Data Analyses;data exchange;Databases;Development;Enrollment;Ensure;Ethics;Evaluation;executive function;experience;extreme prematurity;Faculty;follow-up;Funding;Future;Grant;Hispanic;Hispanic Americans;Hispanic Populations;Human Subject Research;Hybrids;Hydrocortisone;improved;Infant;Institution;Institutional Review Boards;Intervention Studies;Investigation;Knowledge;Laboratories;Lactation;Language;Leadership;Literature;Manuals;Manuscripts;Measures;member;Mentors;Methods;Minority;Mission;Multi-Institutional Clinical Trial;Multicenter Neonatal Research Network;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;Native American population;Native Americans;Neonatal;neonatal hypoxic-ischemic brain injury;neonatal outcome;Neonatology;neuroprotection;New Mexico;Newborn Infant;novel;Observational Study;operation;Outcome;Outcomes Research;participant enrollment;patient population;pediatric pharmacology;Perinatal;Persons;Pilot Projects;Population;Premature Birth;Premature Infant;Preparation;Prevention;Principal Investigator;Process;programs;Progress Reports;protocol development;Protocols documentation;Publications;Publishing;Reproducibility;Research;Research Personnel;Resources;response;Role;Salivary;School-Age Population;secondary analysis;Short-Term Memory;Site;skills;sound;success;Testing;Underrepresented Populations;Universities;verbal

PROJECT_TITLE: Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal ResearchNetwork


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The objective of the NICHD Neonatal Research Network is to improve healthcare and neurodevelopmental outcomes for newborns born premature, low birthweight, or with other serious conditions by performing rigorous and reproducible multi-site clinical trials and observational studies. This consortium of academic medical centers provides the neonatal population and faculty expertise to advance the field of neonatal- perinatal medicine. New opportunities are provided with new protocol proposal and selection processes as well as encouraging the participation of investigators from outside the Network.

PI_NAMEs: CHOCK, VALERIE  (contact)

PROJECT_TERMS: Academic Medical Centers;Address;Admission activity;Adoption;Advisory Committees;Area;Asian;Asian population;base;Beds;Birth;Blood Transfusion;Caring;Cerebrum;Certification;clinical center;Clinical Investigator;Clinical Research;clinical research site;Collaborations;Communities;community engagement;Congresses;COVID-19 pandemic;Data Coordinating Center;demographics;Development;Disparity;Education;Electroencephalography;Ensure;experience;Faculty;Family;follow-up;Funding;Future;Goals;Grant;Growth;health goals;Healthcare;Helping to End Addiction Long-term;high risk;Hispanic;Hispanic Populations;Hospitals;improved;Industry;Infant;Infant Care;Information Dissemination;innovation;Institution;Intervention Trial;Investigation;Journals;Lactation;Lead;Leadership;Low Birth Weight Infant;Magnetic Resonance Imaging;Manuscripts;Medical center;Medicine;member;Mission;Morbidity - disease rate;Mothers;Multi-Institutional Clinical Trial;Multicenter Neonatal Research Network;Multicenter Trials;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;natural hypothermia;Near-Infrared Spectroscopy;Neonatal;neonatal care;neonatal encephalopathy;neonate;Neonatology;Neurodevelopmental Impairment;new technology;Newborn Infant;novel strategies;Observational Study;opioid exposure;Outcome;outcome prediction;Oxygen saturation measurement;pandemic disease;Participant;Patient Care;patient population;Patients;Peer Review;perinatal medicine;Perinatology;Phototherapy;Policies;Population;Population Heterogeneity;Positioning Attribute;Pregnant Women;premature;Premature Infant;Procedures;Process;Productivity;protocol development;Protocols documentation;Public Health;Publications;Publishing;Quality of Care;randomized trial;Reader;Recording of previous events;Reproducibility;Research;Research Design;Research Personnel;Resources;Rest;safety net;Secondary to;Shapes;Site;symposium;Talents;Time;tool;Training;Transfusion;Underserved Population;United States National Institutes of Health;Universities;Visit;Woman

PROJECT_TITLE: NICHD Neonatal Research Network - Stanford University


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Natural Products

ORG_CITY: GAINESVILLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Small molecule therapeutics have tremendously improved human health and the ability to gain access to these materials is fundamental to this endeavor, but the science required towards this goal must continuously evolve to meet contemporary challenges. Here, we aim to develop novel chemical transformations that enable the efficient preparation of chiral scaffolds found in preclinical and clinical agents. The resulting reaction technology will be of utility to discovery chemists and have widespread impact on the synthesis of bioactive molecules.

PI_NAMEs: APONICK, AARON  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Development of Strategies for the Enantioselective Synthesis of Heterocycles and Acyclic Amines

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative/ Public Health Relevance The recent increasing prevalence, severity, and healthcare burden of sinoatrial (SA) node dysfunction emphasize the need for more detailed studies of SA node functions that allow for effective targeted therapy to treat and prevent SA node dysfunction. This project aims to develop a multicellular SA node organoid capable of generating robust pacemaking and conduction by reproducing SA node’s structure and fail-safe mechanism. If successful, the studies will define if tissue-level architecture and multicellular compositions mediate SA node’s robust pacemaking and conduction and may reveal a high-fidelity tissue-level biological pacemaker as a novel therapeutic strategy for SA node dysfunctions.

PI_NAMEs: PARK, SUNG JIN  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adenosine;Adult;Architecture;Arrhythmia;Atrioventricular Block;Biological Assay;Biological Pacemakers;Calcium;Cardiac;Cardiac Myocytes;Cell Reprogramming;cell type;Cells;Childhood;Chronic;chronotropic;Clinical;Clock protein;Connective Tissue;Coupled;Data;design;Development;Disease;drug development;effective therapy;electronic pacemaker;Engineering;Equipment Malfunction;Fibroblasts;Functional disorder;Gene Expression;Genetic Transcription;Goals;HCN4 gene;healthcare burden;Heart Arrest;Heart Atrium;Heart Block;Heart failure;heart rhythm;Human;human induced pluripotent stem cells;Hybrids;Impairment;Implant;implantation;improved;in silico;In Vitro;in vivo;induced pluripotent stem cell derived cardiomyocytes;Inferior;Longitudinal Studies;manufacture;Mediating;Membrane;millisecond;Modeling;Myocardial dysfunction;Newborn Infant;Nodal;nodal myocyte;novel therapeutic intervention;Operative Surgical Procedures;optogenetics;Organoids;overexpression;Pacemakers;Pathway interactions;Patients;pediatric patients;pluripotent stem cell differentiation;Positioning Attribute;Preclinical Testing;Prevalence;prevent;programs;protein expression;public health relevance;Rodent Model;Severities;Shapes;Sick Sinus Syndrome;Sinoatrial Node;Site;Somatic Cell;Structure;targeted treatment;Testing;Theoretical model;Tissues;tool

PROJECT_TITLE: Reverse Tissue-Manufacturing of the Multicellular Sinoatrial Node Organoids

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Networking and Information Technology R&D (NITRD);Social Determinants of Health;Substance Misuse

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Epidemic modeling is vital for reducing the spread of HIV and other infectious diseases, but often these models lack realistic social data, particularly data reflective of the populations impacted by drug use and HIV. In line with the urgent need for better data on the social systems around individuals, our team developed a free, open-source, NIDA/NIH BD2K-funded software suite called Network Canvas. While Network Canvas has already substantially improved the ability of researchers to quickly and accurately capture complex network and contextual data, it requires modernization to further its timely and broad reach and evaluation to understand its impact.

PI_NAMEs: BIRKETT, MICHELLE  (contact);JANULIS, PATRICK FRANCIS

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Acceleration;Adoption;AIDS prevention;Articulation;Automobile Driving;Big Data to Knowledge;cloud based;Collaborations;Collection;Communicable Diseases;Communities;Complement;Complex;Computer software;contextual factors;Country;Data;data quality;design;Development;Disease;Disparity;Drug usage;effective intervention;Electronic Mail;Ensure;Epidemic;Evaluation;experience;FAIR principles;Feedback;Funding;Future;Guidelines;Health;Health Services Accessibility;HIV;Hybrids;Impairment;improved;Incidence;Individual;innovation;insight;Internet;Intervention;Interview;Language;Letters;Literature;marginalized population;Measurement;Methodology;Modeling;Modernization;National Institute of Drug Abuse;Notification;open source;open source tool;Participant;Pathway Analysis;Persons;Pharmaceutical Preparations;Population;Population Dynamics;Populations at Risk;Positioning Attribute;Protocols documentation;Public Health;Reproducibility;Research;Research Personnel;Risk;Schedule;Scientific Advances and Accomplishments;Self Administration;Shapes;social;Social Environment;social factors;Social Network;Software Design;Speed;study population;substance use;success;Surveys;System;Technology;Testing;Time;tool;United States National Institutes of Health;uptake;usability;Work

PROJECT_TITLE: Network Canvas 2.0: Enhancing network data capture for drug use and HIV research


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Adult T-cell leukemia/lymphoma (ATLL) is an extremely aggressive mature T-cell malignancy with limited treatment options. As such, improved understanding of pathogenesis and novel therapeutic strategies are urgently needed. Based on our preliminary studies, we hypothesize that mutations in an epigenetic modifier, EP300, and expression of a transcription factor, BCL6, cooperate to cause abnormalities in gene expression and DNA replication. In this project, we will carry out mechanistic studies to test this hypothesis, and evaluate the efficacy of PARP inhibitor-based therapy in novel preclinical models of ATLL.

PI_NAMEs: YE, BIHUI HILDA (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acetylation;Acetyltransferase;Adult T-Cell Leukemia/Lymphoma;American;Attenuated;B-Lymphocytes;BCL6 gene;Behavior;Biological Assay;Biology;Breast Cancer Cell;c-myc Genes;Caribbean region;CD4 Positive T Lymphocytes;Cell Cycle;Cell Line;Cells;Chemoresistance;chemotherapy;Chromatin;Clinical;Clinical Management;Clonal Expansion;cohort;coping;cytotoxicity;Decitabine;Defect;design;Diagnosis;Disease;DNA biosynthesis;DNA Damage;DNA Methylation;DNA Repair;DNA replication fork;Drug Targeting;E1A-associated p300 protein;efficacy evaluation;Enhancers;EP300 gene;Epigenetic Process;epigenetic regulation;Event;Exons;experience;experimental study;Frequencies;Gene Expression;Genes;Genetic;Genome Stability;genome-wide;Genomic Instability;Genomics;Hematopoiesis;Histones;homologous recombination;Hospitals;Human T-lymphotropic virus 1;Immunoglobulin Genes;improved;in vitro activity;Japan;Japanese;Latin American;Lymphoma cell;Lysine;Malignant - descriptor;Malignant Neoplasms;Mature B-Lymphocyte;Mature T-Lymphocyte;Modification;Molecular;Mutate;Mutation;NF-kappa B;North America;NOTCH1 gene;novel;novel therapeutic intervention;novel therapeutics;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pattern;Phenotype;Physiological;Play;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Pre-Clinical Model;Process;Prognosis;programs;Refractory Disease;replication stress;Reporting;response;Role;S phase;Sampling;Signal Pathway;T-Lymphocyte;targeted agent;targeted sequencing;targeted treatment;Testing;Therapeutic;therapeutic target;Time;TP53 gene;transcription factor;Transcription Repressor;treatment strategy;Variant

PROJECT_TITLE: Epigenetic Alterations and Targeted Therapies in North American ATLL

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The mature brain has a remarkable ability to maintain long-term homeostasis throughout adulthood. We have identified a key molecule, called miR-29, which has an essential function in maintaining the mature brain during normal healthy aging. The experiments we propose focus on investigating the mechanisms of action of miR-29 in the adult brain as well as test its therapeutic efficacy in models of Alzheimer’s Disease.

PI_NAMEs: DESHMUKH, MOHANISH P (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: abeta accumulation;Abeta synthesis;adeno-associated viral vector;adenovirus mediated delivery;Adult;age related neurodegeneration;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's Disease Pathway;Alzheimer's disease patient;Amyloid;Amyloid beta-42;Behavior;beta-site APP cleaving enzyme 1;Biology;Birth;Brain;Brain Diseases;Brain Injuries;cell type;Cerebellum;Defect;Dendritic Spines;Development;Disease;disease phenotype;DNA Methylation;DNMT3a;Embryo;Event;Exhibits;experimental study;Family;Functional disorder;FYN gene;Gene Expression;Gene Expression Profiling;gene repression;Genes;healthy aging;Homeostasis;human stem cells;Hypermethylation;hyperphosphorylated tau;Individual;Injury;Maintenance;member;Methylation;Methyltransferase;MicroRNAs;Modeling;Morphology;mouse model;Mus;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neurologic;Neuronal Differentiation;Neurons;neurotoxic;Organoids;Outcome;overexpression;Pathway interactions;Pattern;Physiological;postmitotic;pre-clinical;Pre-Clinical Model;Proteins;Repression;resilience;restoration;Sampling;single-cell RNA sequencing;stem cell model;Synapses;tau Proteins;Testing;Therapeutic;Treatment Efficacy

PROJECT_TITLE: miR-29: A brain homeostasis molecule for Alzheimer’s disease prevention


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PHR: NARRATIVE Using a multidisciplinary team approach, we are poised to map the cell-type specific genes, pathways, networks, and circuits vulnerable to the TBI pathology across brain regions and time points. We will use a combination of single cell RNA sequencing technology (scRNAseq), multiplexed error robust fluorescent in situ hybridization (MERFISH), advanced network modeling, and experimental validation and functional studies to unravel novel and fundamental gene and cell connectivity perturbations that can be used as biomarkers and targets of TBI in a data-driven, unbiased manner.

PI_NAMEs: GOMEZ-PINILLA, FERNANDO ;WOLLMAN, ROY ;YANG, XIA  (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acute;Address;Affect;Anxiety;Atlases;Behavior;Biological Markers;Brain;brain cell;Brain Concussion;Brain region;Cell Communication;cell type;Cells;Cellular Metabolic Process;Chronic;chronic traumatic encephalopathy;Cognitive;cognitive process;Communities;Complex;Computer Models;Data;Dimensions;Disease;Dose;Emotional;emotional behavior;Energy Metabolism;Event;Fluorescent in Situ Hybridization;frontal lobe;Functional disorder;Gene Expression Regulation;gene network;Genes;Genomics;Goals;Heterogeneity;high throughput technology;Hippocampus;humanin;In Situ;Individual;Inflammation;Injury;innovation;insight;Intervention;Knowledge;Learning;Maps;Measurement;Memory;Mental Depression;Metabolic;Metabolic Pathway;Metabolism;mild traumatic brain injury;Mitochondria;Modeling;Modernization;Molecular;multidisciplinary;Mus;Nervous System Disorder;network models;Neuronal Plasticity;neuropathology;neurotransmission;novel;novel therapeutic intervention;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Pattern;Peptides;Pharmacodynamics;Phase;Population;Post-Traumatic Stress Disorders;prevent;Regulation;Resolution;Resources;response;Role;single cell technology;single-cell RNA sequencing;Site;Social Behavior;spatiotemporal;Sports;Synaptic plasticity;Systems Biology;Technology;Testing;Therapeutic;Time;transcriptome;translational medicine;Traumatic Brain Injury;treatment effect;Validation

PROJECT_TITLE: Spatiotemporal Molecular Substrates of TBI at Single Cell Resolution

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Lung;Maternal Health;Neonatal Respiratory Distress;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: PROJECT NARRATIVE The NICHD Neonatal Research Network’s ongoing commitment to improving health outcomes in infants born preterm and with other high-risk conditions, and reducing known disparities, requires participation of Clinical Centers with track records of high-quality neonatal research. The Lurie Children’s-Northwestern University Study Center (LC-NU SC) in Chicago is a high-volume clinical center with a diverse population, one of the largest high- risk delivery services in the United States (over 12,000 births per year) and 148 NICU beds between the Lurie Children’s Hospital Level IV NICU and the immediately adjacent Prentice Women’s Hospital Level III NICU. With basic science and clinical investigative expertise in perinatal origins of health and disease, the genetic basis of neonatal conditions, neonatal growth and nutrition, health equity, and early detection of neurodevelopmental abnormalities, the LC-NU SC will be a significant contributor to the Neonatal Research Network’s goal of equitable and optimal health outcomes for vulnerable newborns.

PI_NAMEs: HAMVAS, AARON  (contact)

PROJECT_TERMS: Address;Admission activity;adverse maternal outcomes;Advocacy;Basic Science;Beds;Biological Factors;Birth;Chicago;Child;Child health equity;Childhood;Clinical;clinical care;clinical center;Clinical Research;Clinical Trials;Collaborations;Collection;Communities;Complex;Data;Data Coordinating Center;Development;Discipline of obstetrics;Disease;Disparity;Early Diagnosis;Education;Environmental Exposure;Equity;Ethnic Origin;fetal programming;follow-up;Genetic;Geography;Goals;Growth;Health;health equity;health equity promotion;high risk;Hospitals;improved;in utero;infancy;Infant;Infant Mortality;infant outcome;Institution;Intervention;Investigation;Knowledge;Lead;Maternal Mortality;maternal stress;Maternal-fetal medicine;Maternal-Fetal Medicine Units Network;Medical center;medical schools;medically underserved;member;Metabolic;Minority Groups;mother nutrition;Mothers;Multi-Institutional Clinical Trial;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;Neighborhoods;Neonatal;neonatal outcome;Neonatology;Newborn Infant;next generation;novel;nutrition;Obesity;Observational Study;organizational structure;Outcome;outcome disparities;Overweight;Participant;participant retention;Patient Recruitments;pediatric department;Pediatric Hospitals;Perinatal;Physicians;Placenta;Population Heterogeneity;Positioning Attribute;postnatal;Pregnancy Outcome;Pregnant Women;premature;Premature Birth;prenatal;Procedures;Process;Protocols documentation;Provider;Race;Records;recruit;Reduce health disparities;Refractory;Research;Research Infrastructure;Research Institute;Research Personnel;Research Support;Resources;retention rate;Scientist;service delivery;Site;social factors;success;Therapeutic;Training;United States;Universities;White Women;Woman

PROJECT_TITLE: Neonatal Research Network: the Lurie Children's - Northwestern University Study Center


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Research

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: CENTRE FOR ADDICTION AND MENTAL HEALTH

ORG_STATE: ON

PHR: PROJECT NARRATIVE For the first time ever, Lithuania has implemented all three of the World Health Organization’s “best buys” for alcohol control policy within a relatively short timeframe, allowing for an evaluation of their combined effect on health, crime, and violence, as well as an evaluation comparing the costs of their implementation to the return on investment via the reduction in hospitalization rates. Lithuania will be compared to surrounding countries in the eastern part of the European Union, to ensure that any changes observed within the country were not part of a regional trend independent of the “best buy” interventions. The proposed study will provide findings, never before possible, that are generalizable to other high-income countries, such as the United States.

PI_NAMEs: REHM, JUERGEN T (contact);ŠTELEMĖKAS, MINDAUGAS

PROGRAM_OFFICER_NAME: PARASURAMAN, SARIKA RANE

PROJECT_TERMS: Adult;Advertisements;Age;Alcohol consumption;alcohol measurement;alcohol prevention;Alcoholic Beverages;Alcohols;attributable mortality;Baltic States;binge drinking;burden of illness;Cessation of life;Characteristics;Compensation;Consumption;cost;cost comparison;Country;Crime;Data;Deaths of despair;Disease;drinking;Eastern Europe;economic evaluation;Economics;effectiveness measure;Estonia;European;European Union;Evaluation;Expenditure;Future;Government;Health;High Prevalence;Hospitalization;hospitalization rates;Hour;Impact evaluation;implementation cost;improved;Income;Injury;Intervention;Investments;Latvia;Learning;Life Expectancy;Link;Lithuania;Liver Cirrhosis;Measures;minimum drinking age;Morbidity - disease rate;mortality;Outcome;Pattern;Poisoning;Policies;Population;Population Intervention;public policy on alcohol;Publishing;Qualitative Methods;Risk Factors;Sales;sex;Socioeconomic Status;Suicide;Sum;Target Populations;Taxation;Taxes;Time;trend;United States;Violence;World Health Organization;young adult

PROJECT_TITLE: Evaluation of the impact of alcohol control policies on morbidity and mortality in Lithuania and other Baltic states

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative Women with intellectual and developmental disabilities (IDD) face obstacles throughout pregnancy that lead to morbidity and mortality. This project contributes to public health knowledge by using a novel data set of all Medicaid covered pregnancies to women with IDD from 2011-2022 to identify the impacts of pre-pregnancy Medicaid enrollment, adequate prenatal care, and Home and Community Based Service waivers on reducing maternal morbidity for women with IDD. In parallel, we will conduct qualitative interviews with women with IDD who have been or are pregnant to understand their lived experience in relation to Medicaid service use and prenatal enrollment, which will inform and be informed by quantitative analyses.

PI_NAMEs: RUBENSTEIN, ERIC S (contact)

PROJECT_TERMS: Advocate;Affect;Age;Biometry;Birth;Birth Place;care outcomes;Caring;Child;Child Rearing;cohort;Communities;community based service;Continuity of Patient Care;Data;Data Set;Disabled Persons;Disparity;Economics;Education;Enrollment;Ensure;Ethnic Origin;experience;Face;Family;General Population;Gestational Diabetes;Goals;Health;health care disparity;health inequalities;Health Insurance;health knowledge;Healthcare;Healthcare Systems;Home;hospital readmission;Hospitalization;improved;improved outcome;Individual;Inequity;innovation;Institutionalization;Insurance Coverage;Intellectual functioning disability;interest;Intervention;Interview;Involuntary Sterilization;Knowledge;Legal;Lived experience;Low income;maternal morbidity;maternal outcome;maternal risk;Measures;Medicaid;Medicaid services;Methodology;Methods;Modeling;Modification;Morbidity - disease rate;mortality;Mothers;multilevel analysis;National Institute of Child Health and Human Development;novel;Outcome;Pattern;peer;Perinatal Epidemiology;perinatal health;perinatal intervention;Perinatology;Persons;Policies;Postpartum Period;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;prenatal;Prenatal care;prepregnancy;Prevention;Probability;Public Health;Qualitative Research;Race;racism;reproductive;Reproductive Health;Reproductive Rights;Research;Risk;Risk Reduction;Services;social stigma;Sterilization;Stigmatization;Stress;Structure;tool;Transportation;Visit;waiver;Weight;Wisconsin;Woman;women with disabilities;Women's Health;women's morbidity;women's outcomes;Women's Rights;Work

PROJECT_TITLE: Improving pregnancy outcomes for women with intellectual and developmental disabilities in Medicaid

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Frontotemporal dementia is the most common form of dementia for people under age 60, but curative treatment is currently unavailable due to our limited understanding of the molecular etiology. This proposed research aims at developing mass spectrometry-based strategies to determine how GRN mutations, which result in progranulin deficiency, impair lysosomal functions and eventually lead to frontotemporal dementia. The molecular insights gained from this research will decipher the relationship between progranulin, lysosomes, and frontotemporal dementia, providing potential therapeutic target to develop disease- modifying treatments for FTD.

PI_NAMEs: HAO, LING  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Age;ascorbate;Autophagocytosis;Biological;Cells;Cellular biology;Climacteric;curative treatments;Data;Defect;Dementia;Development;Disease;Engineering;Etiology;Exhibits;extracellular;Frontotemporal Dementia;Functional disorder;Genetic;Glycoproteins;Goals;GRN gene;Half-Life;Human;human induced pluripotent stem cells;Impairment;improved;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;innovation;insight;Knock-out;Label;lysosomal proteins;Lysosomes;macromolecule;Mass Spectrum Analysis;Measures;Membrane Proteins;Methodology;Methods;Modeling;Molecular;Mutation;Neurites;Neurodegenerative Disorders;neuronal growth;Neurons;Organelles;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Peptide Hydrolases;Peroxidases;Persons;PGRN gene;pharmacologic;Phenotype;Proteasome Inhibitor;protein degradation;protein TDP-43;Proteins;Proteomics;Reporting;Research;Site;spatiotemporal;Techniques;Technology;Therapeutic;therapeutic target

PROJECT_TITLE: Development of Mass Spectrometry Strategies to Decipher Dynamic Lysosomal Dysfunctions in Frontotemporal Dementia

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Aging;Bioengineering;Biotechnology;Genetics;Hematology;Infectious Diseases;Lung;Nanotechnology;Orphan Drug;Rare Diseases;Regenerative Medicine;Sepsis

PHR: PROJECT NARRATIVE The central objective of the proposed studies is to delineate the molecular mechanisms of defective endothelial regeneration and resolution of inflammatory lung injury in aged lungs, and provide novel approaches to reactivate endothelial regeneration for restoring vascular homeostasis to treat elderly ARDS patients and promote survival.

PI_NAMEs: ZHAO, YOU-YANG  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acute;acute hypoxemic respiratory failure;Acute Respiratory Distress Syndrome;aged;Aging;aging mechanism;aging related;Animals;Bilateral;Binding;Blood Vessels;cecal ligation puncture;Cells;Clinical;Complex;Data;Deacetylation;Death Rate;Dominant-Negative Mutation;Edema;effective therapy;Elderly;Endothelial Cells;endothelial regeneration;Endothelium;Epigenetic Process;Extravasation;Family;forkhead protein;FOXM1 gene;FOXO1A gene;Future;gene-targeted therapy;Genetic;Heart failure;Histone Deacetylase;Homeostasis;Human;Impairment;improved;Incidence;Infiltration;Inflammation;Inflammatory;Injury;Left;Lipopolysaccharides;Lung;lung injury;lung vascular injury;Mediating;Mediator;member;Microvascular Permeability;Modeling;Molecular;mortality;nanoparticle;nanoparticle delivery;novel;novel strategies;novel therapeutic intervention;older patient;Outcome;Pathologic;Pathway interactions;Patients;Pneumonia;polymicrobial sepsis;pre-clinical;programs;promoter;Proteins;Pulmonary Edema;regenerative;repaired;Resolution;restoration;Role;Sepsis;sepsis induced ARDS;Severities;SIRT1 gene;Syndrome;Therapeutic;therapeutically effective;Transcription Repressor;Transgenes;translational potential;Translations;Vascular Permeabilities;Ventricular;young adult

PROJECT_TITLE: Negative regulators of endothelial regeneration in aging lungs and ARDS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(05)]


NIH_SPENDING_CATS: Genetics;Nutrition;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Mitochondrial diseases, the most common group of inherited metabolic disorders, are caused by impairment of oxidative phosphorylation and manifest with severe myopathic and neurological features. Although the energetic defects arising from genetic errors in nuclear and mitochondrial DNA are often known, metabolic targets and many aspects of disease pathogenesis are yet to be elucidated and therefore no proven effective treatments or cures are available. This project investigates the metabolic consequences of oxidative phosphorylation dysfunction and focuses on the development of novel metabolism-based strategies to treat mitochondrial myopathy.

PI_NAMEs: CHEN, QIUYING ;D'AURELIO, MARILENA  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Acceleration;Affect;alpha ketoglutarate;Amino Acids;Arginine;ATP Synthesis Pathway;biomarker panel;biomarker signature;Body Weight decreased;Carbon;Catabolism;Cells;Chronic;Citric Acid Cycle;Citrulline;Clinical;Coenzyme A;Defect;Dependence;Development;Dietary Intervention;Disease;disease model;Disease Progression;Disease stratification;DNA;effective therapy;efficacy evaluation;Evaluation;Face;Functional disorder;Gene Mutation;Genetic;Genetic Diseases;Glutamate Metabolism Pathway;Glutamates;Glutamine;Glycolysis;Goals;Human;Impairment;improved;Inherited;Intervention;Knockout Mice;Knowledge;Link;lipid metabolism;Lipids;man;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolic Pathway;metabolic phenotype;metabolic profile;Metabolism;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial metabolism;Mitochondrial Myopathies;mouse model;Mus;Muscle;Muscle function;Muscle Proteins;Muscular Atrophy;Myoblasts;Myopathy;Naphthoquinones;Neurologic;neuromuscular;novel;Nuclear;oxidation;Oxidative Phosphorylation;Oxidative Phosphorylation Deficiency;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pattern;Phenotype;Phosphorylation;Plasma;Process;profiles in patients;Proteins;Proteolysis;Proteomics;Publishing;Research;response;Role;screening;Skeletal Muscle;Specimen;Starvation;Supplementation;Symptoms;System;targeted treatment;Testing;Therapeutic;therapeutic target;Tissues

PROJECT_TITLE: Metabolic remodeling of skeletal muscle in mitochondrial myopathies

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Narrative Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially life-saving option for many blood disorders, however, it is often complicated by graft-versus-host disease (GvHD) which occurs when the donor’s cells (the graft) perceive the recipient’s healthy cells (the host) as foreign and attack and destroy them. GvHD is spurred by the presence of minor histocompatibility antigens (mHAgs) – proteins found on donor cells that provoke a rejection response if genetically different from the recipient’s cells – often arising from a common type of genetic variation known as nonsynonymous single nucleotide polymorphisms (SNPs). We hypothesize that the identification of tissue-specific mHAgs on an individual recipient-donor basis, predicted through analysis of patient and donor DNA, can enable personalized risk assessment of GvHD, improve current donor selection algorithms and enable personalized tailoring of post-transplant immunosuppression in accordance to patient- specific GvHD risk.

PI_NAMEs: HO, VINCENT TRIEN-VINH;KESKIN, DERIN B (contact);WU, CATHERINE JU-YING

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Acute Graft Versus Host Disease;Address;Affect;Algorithms;Alleles;Allogenic;analysis pipeline;Antigen Presentation;Antigen Targeting;antigen-specific T cells;Antigens;B-Lymphocytes;Binding;Biopsy;Biotechnology;Blood;candidate identification;Cell Line;Cells;chronic graft versus host disease;Clinical;clinically relevant;Code;Collaborations;Collection;Colon;Coupled;Cyclophosphamide;Data;design;Detection;disorder risk;Disparate;DNA;Donor Selection;Epitopes;Ethnic Origin;Evaluation;Event;exome;exome sequencing;experience;Failure;feasibility testing;Female;Genetic Variation;Genomics;Germ Lines;graft vs host disease;Hematological Disease;Hematopoietic Stem Cell Transplantation;Immune response;Immunocompetent;Immunologics;Immunosuppression;improved;Individual;Inflammation;Inherited;Institution;Life;Link;Liver;Lung;male;Maps;Minor Histocompatibility Antigens;Modeling;Molecular;Morbidity - disease rate;mortality;Myelogenous;neoantigens;Neoplasms;next generation;next generation sequencing;Organ;Outcome;Patients;Peptides;Peripheral Blood Mononuclear Cell;personalized genomics;post-transplant;prediction algorithm;Principal Investigator;prognostic;prophylactic;Prophylactic treatment;Proteins;Proteomics;Reporting;response;Risk Assessment;risk prediction;single cell analysis;Single Nucleotide Polymorphism;single-cell RNA sequencing;Skin;Somatic Mutation;T cell response;T-Lymphocyte;Testing;Therapeutic;Tissues;tool;Training;Transplantation;tumor;Validation;Writing;Y Chromosome

PROJECT_TITLE: Systematic identification of minor histocompatibility antigens to address GVHD

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Increasing the number of under-represented minority (URM) PhDs trained in the behavioral, or neurosciences increases diversity in the biomedical workforce. This ENDURE application will facilitate entry into biomedical PhD programs for URM students, by a focus on preparing them as undergrads for admission to competitive, high quality, PhD programs and success once admitted. Research experiential and didactic training, along with increased attention to writing, research literature evaluation and oral presentation at the ENDURE Meeting will ensure that this ENDURE program continues to facilitate entry of URM students into neuroscience PhD programs.

PI_NAMEs: VEGA, IRVING E (contact)

PROGRAM_OFFICER_NAME: JONES, MICHELLE

PROJECT_TERMS: Address;Admission activity;Advisory Committees;African American student;Area;Asian Americans;Attention;Award;Behavioral;Behavioral Sciences;Biology;Biomedical Engineering;Brain;candidate selection;career;Career Choice;Collaborations;college;Communication;Communities;comparative;Dedications;Development;disabled;Disease;Dissection;Distant;Doctor of Medicine;Doctor of Philosophy;Drug Addiction;Education;Education Projects;Educational workshop;Enrollment;Ensure;ethnic minority;Etiology;Evaluation;experience;experimental study;Extramural Activities;Faculty;falls;Feeling;Funding;Goals;graduate school;Grant;Hispanic;Hispanic Americans;Historically Black Colleges and Universities;Human;Hurricane;improved;Institution;instrument;interdisciplinary approach;Interview;Island;Journals;Literature;Medicine;meetings;Mental disorders;Mentors;Mentorship;Methodology;Michigan;Minority Participation;minority scientist;Minority-Serving Institution;Monitor;National Institute of Neurological Disorders and Stroke;Native Americans;Nervous System Disorder;Neurobiology;Neurons;Neurosciences;Neurosciences Research;New Mexico;news;North Carolina;Oral;Outcome;Paper;Pharmacology;Pharmacology and Toxicology;Physiology;Population;Population Scientist Supplement (R25);Positioning Attribute;Privatization;Process;programs;Psychology;Puerto Rican;Puerto Rico;racial minority;Research;Research Personnel;Research Project Grants;residence;Science;Scientist;Secure;Sheep;skills;Societies;statistics;STEM student;Stream;Stress;Structure;Student recruitment;Student Selections;Students;success;summer research;Talents;Time;Training;translational approach;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;Update;Work;Writing

PROJECT_TITLE: Bridge to the PhD in Neuroscience


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Nutrition;Obesity;Prevention

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The Data Coordination Center (DCC) will have scientific and coordination responsibilities for the Clinical Centers, NIDDK Project Scientist, and oversight bodies for the consortium studying the Physiology of the Weight Reduced State. The DCC will provide scientific, analytical, logistical, and administrative expertise to support the consortium which will include a weight loss intervention and weight loss maintenance study “to elucidate the physiology of the weight reduced state and the mechanisms of individual variability in weight maintenance.” This includes study design, implementation and monitoring, data management, data analysis, interpreting and reporting findings, facilitating ancillary studies, and tracking and archiving data and biospecimens.

PI_NAMEs: BELLE, STEVEN H. (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Address;Adult;Affect;Ancillary Study;archive data;Archives;Behavior Therapy;Behavioral;Biometry;Body Weight decreased;central database;clinical center;clinical database;Clinical Trials;Clinical Trials Data Monitoring Committees;cohort;Collaborations;Communication;Data;Data Analyses;data centers;Data Coordinating Center;data management;Data Management Resources;data sharing;design;distributed data;Documentation;efficacy evaluation;Energy Intake;Energy Metabolism;epidemiologic data;Epidemiology;Equipment and supply inventories;experience;Genetic Materials;Goals;graduate school;Human Resources;individual variation;Institutional Review Boards;Intervention;Knowledge;Laboratories;Life Style;lifestyle intervention;Maintenance;Measures;meetings;Metabolic;Molecular;Monitor;Multi-Institutional Clinical Trial;National Institute of Diabetes and Digestive and Kidney Diseases;Obesity;Observational Study;operation;Outcome;Output;Overweight;Participant;Phase;Physiology;Preparation;Procedures;Process;prospective;Prospective, cohort study;Public Health Schools;Publications;recruit;Regulation;Reporting;Research;Research Design;Resources;Safety;Scientific Advances and Accomplishments;Scientist;Secure;Serum;Site;Specimen;Statistical Data Interpretation;statistics;symposium;System;Tissue Sample;Training;Universities;Weight;weight loss intervention;weight maintenance

PROJECT_TITLE: The Physiology of the Weight Reduced State Data Coordinating Center


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE  There are currently no disease modifying therapies for the spinocerebellar ataxias. One important barrier for development of new therapies for spinocerebellar ataxia and other neurodegenerative diseases is the lack of tools to objectively and sensitively measure a beneficial clinical response to a drug. This project aims to develop systems based on everyday technologies and sophisticated computational methods to provide accessible tools for early detection, precise severity measurement, and prediction of disease progression in spinocerebellar ataxias.

PI_NAMEs: GUPTA, ANOOPUM SATYAWAN (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Affect;Age of Onset;Algorithms;arm;arm function;arm movement;Assessment tool;Ataxia;Behavior;Behavior assessment;behavior test;Behavioral;behavioral phenotyping;Biological Markers;Cellular Phone;Characteristics;Classification;Clinic;Clinic Visits;Clinical;Clinical assessments;Clinical Trials;Collection;Computer Vision Systems;Computers;Computing Methodologies;Data;Data Collection;Data Set;Detection;Development;diagnostic tool;digital;Disease;disease classification;Disease Progression;drug development;Early Diagnosis;Early identification;Education;effective therapy;efficacy evaluation;experience;Eye Movements;Face;Generations;Genes;Geographic Locations;Goals;Grain;handheld mobile device;Home;Human;illness length;improved;Individual;insight;Knowledge;Label;Learning Disorders;Length;Machine Learning;machine learning model;Measurement;Measures;member;Methodology;Methods;microphone;Modality;Modeling;Motor;motor behavior;motor control;motor deficit;Movement;multimodality;Mus;Nervous System Disorder;Neurodegenerative Disorders;Neurology;Neurosciences;novel;novel strategies;novel therapeutics;oculomotor;Onset of illness;open data;open source;Outcome Measure;Parkinson Disease;Parkinsonian Disorders;Patient Outcomes Assessments;Patient Recruitments;patient retention;Patients;Pattern;personalized predictions;Pharmaceutical Preparations;point of care;primary outcome;prognostic;prognostication;response;Sample Size;sensor;Severities;Severity of illness;signal processing;Signal Transduction;Socioeconomic Status;Speech;Spinocerebellar Ataxias;System;Technology;Testing;Time;tool;Training;treatment response;Trinucleotide Repeats;Vision

PROJECT_TITLE: A Computational Approach for Quantifying Motor Behaviors in Spinocerebellar Ataxias to Improve Early Detection of Motor Signs and Precisely Estimate Disease Severity and Disease Change

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Contraception/Reproduction;Infertility;Maternal Health;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Almost half of the women of reproductive age in the U.S. are deficient in iodine. We will apply advanced novel methods to measure urinary iodine in women during preconception and throughout pregnancy and in the placenta to estimate the effects of iodine deficiency before and during pregnancy on critical reproductive and perinatal health outcomes including infertility, pregnancy loss, preterm delivery, and birth size. Iodine is a low- cost intervention, that could be used to target women at risk for adverse outcomes.

PI_NAMEs: HINKLE, STEFANIE NICOLE (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: Address;adverse outcome;Age;aged;Attenuated;Birth;Birth Weight;Brain Injuries;Classification;Clinical;cohort;Collection;Conceptions;cost;cost effective;critical period;design;Development;Dietary intake;early pregnancy;early pregnancy loss;Emotional;Endocrinologist;Epidemiologist;evidence base;experience;Fertility;fertility improvement;Fetus;Fortification;Goals;Growth and Development function;Health Promotion;Heterosexuals;High Risk Woman;High-Risk Pregnancy;Hormones;Hybrids;Hypothyroidism;Individual;Infertility;innovation;Intervention;intervention cost;Investigation;Iodine;iodine deficiency syndrome;Late pregnancy;Live Birth;Measurement;Measures;Methods;Micronutrients;novel;Nutritionist;offspring;Outcome;Outcome Study;Perinatal;perinatal health;perinatal outcomes;Personal Satisfaction;Placenta;Placentation;Policies;Predisposition;Pregnancy;Pregnancy Complications;Pregnancy loss;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;prevent;Production;Recommendation;repository;Reproduction;reproductive;Reproductive Health;reproductive outcome;Research;Research Design;Risk;Role;Sampling;social;Spottings;subfertility;Supplementation;therapy outcome;Thyroid Hormones;Time;urinary;Urine;Woman;Women's cohort;Work

PROJECT_TITLE: Iodine Deficiency: Novel assessment methods and implications for reproductive health

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Project Narrative In 2050, people older than 65 will be almost double the number in 2012, increasing the importance of late life cognitive functions, which in animals depend on new neuron production in the hippocampus, the ability of new neurons to connect in brain circuits, and brain regional blood flow. There have been controversial finings regarding the ability of the human hippocampus to make new neurons throughout our lifespan, and data suggest that aging is associated with decreased connections between neurons, and reduced blood supply in the neurogenic niche, which can affect brain function. The proposed research will, for the first time, identify molecular features of the hippocampus neurogenic niche, providing anatomical mapping of gene and protein expression at the single-cell level, and allow studying changes occurring across the human lifespan in normally aging individuals from adolescence to over 90 years of age, and compare healthy aging with Alzheimer's disease.

PI_NAMEs: BOLDRINI, MAURA  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Abeta synthesis;Adolescence;Adult;adult neurogenesis;Affect;Age;age related;age related decline;Age Years;Aging;Alzheimer's Disease;Amyloid beta-Protein;Anatomy;angiogenesis;Animal Model;Animals;Anti-Inflammatory Agents;ATAC-seq;Autopsy;axon guidance;Bar Codes;BETA2 protein;Biological Assay;Birth;Brain;Brain region;brain tissue;Cell Differentiation process;Cell model;Cell Nucleus;Cell Proliferation;cell type;Cells;Cessation of life;Chromosome Mapping;Clinical;cognitive function;Collection;Custom;Data;dentate gyrus;differential expression;Electron Transport;Embryo;emotional functioning;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Exclusion Criteria;Exons;Failure;Female;Gene Expression;Genes;Genetic Transcription;Genomics;Glial Fibrillary Acidic Protein;gliogenesis;healthy aging;Hippocampus;Human;human old age (65+);Immunofluorescence Immunologic;Impaired cognition;Impairment;indexing;Individual;Inflammation;juvenile animal;Knowledge;late life;Letters;Life;life span;Location;Maintenance;male;Mammals;Maps;Mass Spectrum Analysis;Messenger RNA;Metabolism;Methods;Mitochondria;Molecular;Molecular Target;mRNA Expression;Multipotent Stem Cells;Mus;NCAM1 gene;nerve stem cell;nestin protein;neurogenesis;Neuroglia;Neuronal Plasticity;Neurons;neuropathology;new technology;normal aging;novel;Older Population;Ontology;polysialyl neural cell adhesion molecule;Population;preservation;Production;progenitor;Proliferating;protein expression;Proteins;Proteomics;Regional Blood Flow;Regulation;Reporting;Repression;Research;Resolution;RNA;RNA Splicing;Sampling;sex;single nucleus RNA-sequencing;Slide;Small Nuclear RNA;stem;stem cell differentiation;stem cell fate;stem cell proliferation;stem cells;Sudden Death;Synapses;Synaptic plasticity;synaptogenesis;tau Proteins;Technology;Temporal Lobe;Testing;Time;Tissues;Toxicology;transcriptomics;Uniport;Vascular blood supply;Visualization;Western Blotting;WNT Signaling Pathway

PROJECT_TITLE: New technologies to identify molecular regulators of the human hippocampus neurogenic niche in healthy aging and Alzheimer's Disease


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative G-protein coupled receptors (GPCRs) reside on the cell surface positioned to receive a wide range of cues (from photons to odors to hormones) and to elicit a response in the corresponding cell. GPCRs are targets of an estimated 34% of all currently approved drugs, yet we do not fully understand the events upstream or downstream of their activation. This proposal will determine how a single GPCR functions in the development of two very different organs and it identifies other GPCRs that also function in these same organs.

PI_NAMEs: ANDREW, DEBORAH J (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Actins;Adult;Affect;Animals;Apical;Autonomic nervous system;Cell membrane;cell motility;Cell Polarity;Cell Shape;Cell surface;Cell Survival;Cells;Central Nervous System;Collaborations;Conflict (Psychology);constriction;cost;Cues;Destinations;Development;Developmental Process;Dictyostelium;Disease;Distant;Drosophila garnet protein;Drosophila genome;Drosophila genus;Drug Targeting;Embryo;Embryonic Development;Enzymes;Epithelium;Erinaceidae;Event;Extracellular Matrix;Extravasation;F-Actin;FDA approved;Fogs;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genes;Genetic;genome wide screen;Germ Cells;Glutaminase;Hormones;Human;Immune;Immunity;in vivo;Inflammation;Injury;insight;Life;Ligands;Light;Link;lipid phosphate phosphatase;Mediating;Membrane;migration;Molecular;Molecular Mechanisms of Action;Morphogenesis;Neoplasm Metastasis;neuroblast;Neurotransmitters;novel;Odors;Organ;Organism;Organogenesis;Oxidoreductase;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;Pheromone;Photons;Play;polymerization;Polymers;Positioning Attribute;pressure;Process;Proteins;receptor;Receptor Activation;receptor binding;receptor function;recruit;Reporting;response;RNA Interference;Role;Salivary Glands;Signal Pathway;Signal Transduction;Site;Smell Perception;Smog;smoothened signaling pathway;Somatic Cell;Source;Stimulus;Structure of primordial sex cell;System;Taste Perception;Testing;Time;tissue/cell culture;Tissues;tool;Tube;Visual;Wing;Work

PROJECT_TITLE: GPCR signaling during embryonic organ formation

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]