ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: Columbus

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Our Maternal and Pediatric Precision in Therapeutics (MPRINT) Translational Research Resource Platform (TRRP) will conduct goal-directed innovative translational research to understand maternal-fetal drug exposure and placental response relationships. Using preeclampsia preventive treatment with aspirin as a case study, we will characterize placental exosome proteome profiles as biomarkers of placental health and drug response and correlate our findings with maternal outcomes. As a component of the MPRINT infrastructure, our groundbreaking TRRP is designed to serve as a scalable expertise and services resource to support future research in maternal-pediatric therapeutic areas of high unmet need.

PI_NAMEs: COSTANTINE, MAGED  (contact);MENON, RAMKUMAR

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: adverse pregnancy outcome;Affect;Alkaline Phosphatase;American College of Obstetricians and Gynecologists;Area;Aspirin;biobank;Biological Markers;Birth;Case Study;Cells;Characteristics;Childhood;Clinical;clinical care;Clinical Drug Development;cohort;Collection;Communities;Data;Dependence;design;Development;differential expression;dosage;Dose;drug efficacy;Drug Evaluation;Endothelium;Exclusion;exosome;extracellular vesicles;fetal;fetal drug exposure;Fetal Growth Retardation;Fetus;Foundations;Funding;Gestational Age;Goals;Health;Iatrogenesis;improved;in vivo;Individual;Inflammatory;Infrastructure;innovation;insight;Institutional Review Boards;Investigation;Lactation;maternal morbidity;Maternal Mortality;maternal outcome;Maternal-Fetal Medicine Units Network;Mediating;Modeling;Monitor;National Institute of Child Health and Human Development;neonatal morbidity;Neonatal Mortality;novel;novel marker;Ohio;Orphan;Outcome;particle;patient advocacy group;Patients;Persons;Pharmaceutical Preparations;Physiological;Placenta;Plasma;Play;Populations at Risk;Pre-Eclampsia;Pregnancy;pregnancy health;Pregnancy Outcome;pregnant;Premature Birth;Prevention;Preventive treatment;Professional Organizations;prognostic;prospective;Proteins;Proteome;Randomized, Controlled Trials;Recommendation;recruit;Research;Research Design;Resources;response;Risk;Role;Safety;Sampling;Second Pregnancy Trimester;Seminal;Services;specific biomarkers;success;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Therapeutic Research;Therapeutic Trials;Third Pregnancy Trimester;Time;Translational Research;translational therapeutics;treatment response;trophoblast;United States;United States National Institutes of Health;United States Preventative Services Task Force;Universities

PROJECT_TITLE: Developing Extracellular Vesicle Based MPRINT Translational Resource Platform for Monitoring Therapeutics Response During Pregnancy


ADMINISTERING_IC: AR

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Facioscapulohumeral Muscular Dystrophy;Gene Therapy;Genetics;Muscular Dystrophy;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: CHAMBERLAIN, JEFFREY S (contact)

PROJECT_TERMS: 3-Dimensional;Address;adeno-associated viral vector;adenovirus mediated delivery;Adverse event;Animal Model;Animal Muscular Dystrophy;Animals;Biological Markers;Biopsy;Blood Cells;Capsid;Cardiac;Clinic;Clinical;clinical application;Clinical Data;Clinical Research;clinical translation;Clinical Trials;clinically relevant;Complex;Conduct Clinical Trials;Data;data modeling;Depressed mood;design;Development;Disease;Disease Progression;DNA cassette;DNA Sequence Alteration;Dose;Duchenne muscular dystrophy;Dystrophin;Enhancers;Enzymes;Evaluation;Facioscapulohumeral Muscular Dystrophy;Gene Delivery;Gene Silencing;gene therapy;Gene therapy trial;Generations;Genes;Genetic;Genetic Transcription;Goals;Heart;hemodynamics;Homeobox Genes;Human;human induced pluripotent stem cells;Immune;Immune response;Immunity;immunogenicity;immunoreaction;improved;Industry;Inflammation;Inheritance Patterns;Inherited;Injections;innovation;intein;Intervention;knock-down;Knowledge;Length;Magnetic Resonance Imaging;Measures;Messenger RNA;micro-dystrophin;Miniature Swine;miniaturize;Modeling;Molecular;Monitor;mouse model;Mus;Muscle;muscle engineering;Muscle function;Muscular Dystrophies;Myocardium;Myopathy;Myosin ATPase;next generation;novel;novel strategies;overexpression;Pathology;patient screening;Patients;Phenotype;Play;porcine model;promoter;Proteins;Publishing;Rattus;Reagent;Research;Ribonucleotide Reductase;RNA Interference;RNA Interference Therapy;RNAi vector;Role;Series;Serious Adverse Event;Serotyping;Skeletal Muscle;small molecule;synergism;System;T-Lymphocyte;Testing;Therapeutic;therapeutic candidate;tool;Toxic effect;Transcript;transgene expression;Transgenes;translational study;Variant;vector

PROJECT_TITLE: Overcoming limitations for AAV gene therapy


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: NARRATIVE Approximately 20% of patients with metastatic castration-resistant prostate cancer, the lethal form of prostate cancer, have alterations in the genes that help repair damage in DNA. These alterations may predict a patient's response to a new class of cancer drugs called PARP inhibitors. Our project will distinguish harmful alterations, which may predict drug response, from benign variants.

PI_NAMEs: SAWYERS, CHARLES L. (contact)

PROJECT_TERMS: Alleles;androgen deprivation therapy;androgen independent prostate cancer;Antineoplastic Agents;Benign;Biological Assay;Biological Markers;BRCA1 gene;BRCA2 gene;Cells;CHD1 gene;Chromosomal Stability;Clinical;Clinical Research;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;CRISPR/Cas technology;Data;Defect;design;Disease;DNA;DNA Repair;Drug Exposure;drug response prediction;drug sensitivity;Engineering;Evaluation;experience;Fanconi Anemia Complementation Group A Protein;Fanconi Anemia-BRCA Pathway;Gene Mutation;gene repair;Genes;Genetic;genetic variant;Genome;genome analysis;genome editing;genome sequencing;genomic locus;Genomics;Germ Lines;Germ-Line Mutation;Goals;Grant;Heterozygote;high risk;insertion/deletion mutation;loss of function mutation;Malignant neoplasm of prostate;Mediating;men;Missense Mutation;Modeling;Molecular;mutant;Mutation;next generation sequencing;Organoids;Outcome;PALB2 gene;participant enrollment;Pathogenesis;Pathogenicity;Pathway interactions;patient population;patient response;Patients;Pharmaceutical Preparations;Phenotype;Physiological;Poly(ADP-ribose) Polymerase Inhibitor;Prevalence;prostate cancer cell;prostate cancer cell line;prostate cancer risk;Protein Truncation;Radical Prostatectomy;Recurrence;repaired;Research;Research Personnel;response;Site;Somatic Mutation;stability testing;Technology;Testing;Therapeutic;treatment response;tumor;Tumor-Derived;Variant;whole genome

PROJECT_TITLE: Functional Evaluation and Interpretation of DNA Damage Repair Variants in Prostate Cancer


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: ROCKVILLE

ORG_NAME: SANARIA, INC.

ORG_STATE: MD

PHR: PROJECT NARRATIVE The WHO has called for a malaria vaccine that is highly effective against parasite infection; Sanaria’s PfSPZ vaccines are the only candidates that have demonstrated the high efficacy needed to eliminate malaria by vaccination. PfSPZ vaccines are manufactured from live Plasmodium falciparum sporozoites (PfSPZ) currently in mosquitoes and in the future in vitro. We propose to de-couple the upstream stages of vaccine manufacturing by culturing Pf ookinetes in vitro, then purifying and cryopreserving the ookinetes prior to their use in PfSPZ vaccine production. With cryopreserved ookinetes that are viable upon thawing from stable storage conditions we will be able to initiate PfSPZ production campaigns without need for fresh blood and serum and gametocyte production currently needing ~30 days. Likewise, front-end manufacturing of PfSPZ in vitro will be highly standardized and the culturing time greatly reduced with the underlying aim of developing a scalable manufacturing schema.

PI_NAMEs: HOFFMAN, STEPHEN LEV (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Address;African;Anopheles Genus;Antigens;Biological;Biological Assay;Bioreactors;Blood;Chitinase;comparative;Complex;cost;Country;Cryopreservation;Culicidae;density;Dissociation;Divorce;Excision;extracellular;feeding;Female;flexibility;Fluorescent Dyes;Future;Germ Cells;Goals;Good Manufacturing Process;Grant;Human;In Vitro;Infection;large scale production;Link;Location;Magnetism;Malaria;malaria infection;malaria transmission;Malaria Vaccines;male;manufacture;matrigel;Membrane;Membrane Proteins;Methods;Motility;Nature;Oocysts;Parasites;Parasitic infection;Plasmodium falciparum;Plasmodium falciparum vaccine;Pregnant Women;prevent;Process;Production;Protocols documentation;Quality Control;Readiness;Serum;Specific qualifier value;Sporozoite vaccine;Sporozoites;Standardization;Structure;Survival Rate;Testing;Time;timeline;transmission process;uptake;Vaccination;vaccine efficacy;Vaccine Production;Vaccines;Work;zygote

PROJECT_TITLE: Modularizing manufacture of PfSPZ vaccines: ookinete production for PfSPZ manufacture in mosquitoes and in vitro

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(10)]


PI_NAMEs: KANTOFF, PHILIP W (contact)

PROJECT_TERMS: Archives;authority;Collaborations;Communication;Communities;Decision Making;DNA Repair;editorial;Elements;Ensure;Evaluation;Fostering;Goals;Grant;Human Resources;Individual;Infrastructure;Institution;Malignant neoplasm of prostate;Manuscripts;Medical;meetings;member;Memorial Sloan-Kettering Cancer Center;National Cancer Institute;Occupational activity of managing finances;Office of Administrative Management;Principal Investigator;Program Research Project Grants;programs;Publications;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Running;Schedule;scientific organization;Services;Structure;Training;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Human Genome;Patient Safety;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE Alterations in genes that help repair damaged DNA, in particular BRCA2, are present in 20-30% of patients with castration-resistant prostate cancer, but the biologic and clinical significance of these alterations remains poorly defined. The Genomics Core will be critical to achieving the overall aims of this program by assisting in the molecular characterization of tumor and normal tissues and patient-derived and engineered models of prostate cancer. The core will also facilitate the sharing of data on inherited and acquired genomic alterations among the program investigators and with the broader research community.

PI_NAMEs: SOLIT, DAVID B. (contact)

PROJECT_TERMS: Aftercare;Alleles;androgen independent prostate cancer;Area Analyses;authority;Bioinformatics;Biological;Biological Assay;Biological Markers;Biometry;Biopsy;BRCA2 gene;cancer genetics;cancer genomics;Cancer Patient;cancer risk;cBioPortal;CDH1 gene;cell free DNA;cellular engineering;Clinical;Clinical Trials;clinically relevant;clinically significant;cohort;Cohort Analysis;Collaborations;Communities;Consent;Dana-Farber Cancer Institute;Data;Data Analyses;data resource;Data Set;data sharing;data visualization;database of Genotypes and Phenotypes;Decision Making;Deposition;Diagnosis;Disease;DNA;DNA Repair;DNA Sequence Alteration;DNA sequencing;Doctor of Philosophy;Drug resistance;Engineering;Enrollment;Ensure;Ethnic Population;exome;exome sequencing;experience;Formalin;Gene Mutation;gene repair;Genes;genome sequencing;genomic data;Genomic Data Commons;genomic profiling;Genomics;Germ Lines;Germ-Line Mutation;Goals;Heritability;high risk;hormone therapy;Human Resources;improved;Individual;Inherited;Institutional Review Boards;Link;Malignant neoplasm of prostate;Mediating;Memorial Sloan-Kettering Cancer Center;men;Mission;Molecular;Molecular Analysis;molecular oncology;Molecular Profiling;Monitor;mutant;Mutation;next generation sequencing;Normal tissue morphology;novel;Outcome;Paraffin Embedding;PARP inhibition;participant enrollment;Pathogenicity;Pathologist;Pathology;Pathway interactions;Patient Monitoring;patient screening;Patients;Plasma;Poly(ADP-ribose) Polymerase Inhibitor;programs;prospective;prostate cancer model;prostate cancer risk;Prostatic Neoplasms;Protocols documentation;public repository;Publishing;Research;Research Personnel;Research Project Grants;Residual Neoplasm;Resistance;response;Risk;Running;Sampling;Somatic Mutation;standard of care;success;Surgical Pathology;targeted sequencing;Testing;therapy resistant;Time;Tissue Embedding;Training;transcriptome sequencing;treatment response;treatment strategy;tumor;tumor DNA;Tumor Tissue;Validation;Variant;whole genome;Work

PROJECT_TITLE: Genomics Core


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Facioscapulohumeral Muscular Dystrophy;Genetics;Muscular Dystrophy;Orphan Drug;Rare Diseases

PI_NAMEs: TAPSCOTT, STEPHEN J (contact)

PROJECT_TERMS: Artificial Intelligence;automated analysis;automated segmentation;Biological Markers;biomarker validation;Biopsy;Cell Line;Cellular Assay;Characteristics;Clenbuterol;Clinical;clinical care;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Cohort Studies;Collaborations;D4Z4;Data;Data Set;design;Development;Disease;disease model;Disease Progression;Dose;drug development;early detection biomarkers;efficacy clinical trial;Evaluation;Extracellular Matrix;Facioscapulohumeral;Family;Family suidae;Fatty acid glycerol esters;follow-up;Foundations;Funding;Future;gait examination;Gene Expression;gene-targeted therapy;Genes;Genetic;Genetic Transcription;Goals;Histology;Human;improved;In Vitro;Individual;Inflammation;Longterm Follow-up;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Mammals;Measurement;Measures;Modeling;Molecular;molecular marker;Molecular Profiling;Muscle;Muscle Cells;Muscular Dystrophies;Myoblasts;Natural History;Needles;Onset of illness;open label;Outcome Measure;Pathology;Pathway interactions;Patient Outcomes Assessments;Patients;Performance;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;Phenotype;porcine model;Pre-Clinical Model;predictive modeling;Predictive Value;programs;prospective;rate of change;Readiness;Regulation;Research;Safety;safety study;secondary outcome;Site;success;Task Performances;Techniques;Testing;Therapeutic Clinical Trial;therapeutic development;Time;tool;Transgenic Organisms;treadmill;trial design

PROJECT_TITLE: Facioscapulohumeral dystrophy clinical trial foundations


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Clinical Research;Digestive Diseases;Genetics;Microbiome;Prevention;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Microscopic colitis is a common cause of watery diarrhea particularly in older adults. This often-debilitating disease has received insufficient research attention. The proposed research is designed to improve our understanding of the etiology of microscopic colitis, an important step in developing interventions to decrease the burden.

PI_NAMEs: SANDLER, ROBERT S. (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Adrenergic beta-Antagonists;anti-depressive agents;Attention;Belief;Biodiversity;Biopsy;Body mass index;Case/Control Studies;Chronic;Clinical;Colon;Colonoscopy;colorectal cancer screening;comparison control;comparison group;Control Groups;Data;Data Collection;design;Development;Diarrhea;dietary;differential expression;Disease;Economic Burden;Enrollment;Etiology;experimental study;Exposure to;Fecal Incontinence;Female;Functional disorder;Funding;Genes;genetic signature;Guidelines;gut dysbiosis;Health behavior;Hormonal;Hormones;improved;Incidence;Inflammatory Bowel Diseases;insight;Intervention;Interview;Life;Life Style;lifestyle factors;Link;Lipids;Medical History;metagenomic sequencing;Metagenomics;microbial;microbiome;Microscopic Colitis;Mucous Membrane;Non-Steroidal Anti-Inflammatory Agents;Obesity;older adult;Oral Contraceptives;Organism;participant enrollment;Patients;Pharmaceutical Preparations;Phase;Physicians;Play;Postmenopause;prevent;prospective;Proteobacteria;Recommendation;Recurrent disease;Reporter;Research;Risk;Risk Factors;Role;Sampling;screening;Selective Serotonin Reuptake Inhibitor;Shotguns;Signal Transduction;social;sociodemographics;Structure;Study Subject;Symptom Burden;Symptoms;Telephone Interviews;Therapeutic;transcriptome sequencing;United States National Institutes of Health;Withdrawal;Woman

PROJECT_TITLE: Risk Factors for Microscopic Colitis

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The demonstration that some patients with carotid artery stenosis are living with preventable cognitive impairment has significant public-health impact. The estimated prevalence of asymptomatic, severe, carotid artery stenosis is 2% of the general population over age 60, or 124,000 people in the US alone in 2010. Extrapolating from a Canadian study that estimated per patient costs of vascular cognitive impairment, if even 10% of these patients had cognitive dysfunction, annual societal costs could be as high as $2.5 billion.

PI_NAMEs: LAZAR, RONALD M;LIEBESKIND, DAVID SIGMUND;MARSHALL, RANDOLPH S (contact);MESCHIA, JAMES F

PROGRAM_OFFICER_NAME: JANIS, SCOTT

PROJECT_TERMS: Address;Affect;Age;Anatomy;arm;Blinded;Brain imaging;Carotid Endarterectomy;Carotid Stenosis;Carotid stent;Case Series;cerebral blood volume;cerebral hemodynamics;Cerebral Infarction;Cessation of life;Circle of Willis;Clinical;Clinical Research;Cognition;Cognitive;cognitive change;cognitive function;cognitive performance;Core-Binding Factor;cost;Data;Disease;Enrollment;Failure;follow-up;Funding;General Population;Grant;hemodynamics;Hemorrhage;Image;imaging biomarker;Impaired cognition;Impairment;improved;Infarction;Intervention;Magnetic Resonance Imaging;Measures;Medical;Mental Depression;mild cognitive impairment;Natural History;Nature;Outcome;pandemic disease;Parents;patient subsets;Patients;Pattern;Perfusion;Persons;Phase III Clinical Trials;Physiological;Population;preclinical study;Prevalence;Process;Protocols documentation;Public Health;Randomized;randomized, clinical trials;recruit;Recurrence;revascularization;Risk;Side;societal costs;Specificity;Stenosis;Stroke;Stroke prevention;Testing;Thick;Time;Treatment Failure;Vascular Cognitive Impairment;White Matter Hyperintensity

PROJECT_TITLE: Carotid Revascularization and Medical Management for Asymptomatic CarotidStenosis Trial - Hemodynamics (CREST-H)

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: Project Narrative Computational docking is an essential tool for drug discovery and design, and it has been essential to the development of many drugs currently in clinical use. Nevertheless, there are many challenges that still need to be addressed, from the availability of better models to calculate predicted binding affinity, to methods to support virtually screen libraries containing billions of chemicals from which potential drug candidates could be identified. We are proposing to develop better tools to address these challenges, to improve speed, accuracy, and provide the capability of navigating through these large libraries.

PI_NAMEs: FORLI, STEFANO  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Adopted;Affect;Affinity;Algorithms;Binding;Calibration;Case Study;Charge;Chemicals;Clinical;Code;Communities;Computer software;Cryoelectron Microscopy;Data;Democracy;design;Development;Docking;Documentation;drug candidate;Drug Design;drug discovery;Entropy;Environment;Evaluation;Exhibits;Feedback;flexibility;Freedom;Future;Homology Modeling;improved;Individual;Laboratories;Libraries;Licensing;Ligand Binding;Ligands;macromolecular assembly;Macromolecular Complexes;Methods;Modeling;models and simulation;Modernization;Molecular;Molecular Conformation;Molecular Structure;online resource;open source;Pathway interactions;Performance;Periodicals;Pharmaceutical Preparations;Phase;Play;Process;programs;Protein Conformation;Protein Region;prototype;Publications;Quantum Mechanics;receptor;Research Personnel;Research Support;Resolution;Resources;Roentgen Rays;Sampling;Scoring Method;Screening Result;Side;small molecule;Software Design;software development;Solvents;Speed;Structural Models;Structure;success;Surveys;tool;Training;Update;Vertebral column;virtual;virtual library;virtual screening;Water;web services

PROJECT_TITLE: AutoDock Suite:  High Performance Software Environment for Drug Design


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: WAYLAND

ORG_NAME: GENERAL BIOPHYSICS, LLC

ORG_STATE: MA

PHR: PHASE II APPLICATION (STTR Program PAS-22-197) Title: Phase 1 Trial to Assess Safety and Immune Effects of Xenon Gas in Healthy Human Subjects Narrative We showed that Xenon gas (Xe) delivered through inhalation suppresses neurodegenerative microglia and ameliorates Alzheimer’s Disease (AD)-like pathology associated with decreased Ab-plaques in AD mouse models. The goal of this proposal is to perform Phase 1 dose-escalation safety study in healthy human subjects. This is the first clinical trial of Xe inhalation AD therapy in humans and its successful completion will allow initiation of safety and efficacy clinical trial in AD patients.

PI_NAMEs: ILIN, ILYA  (contact);WEINER, HOWARD L

PROGRAM_OFFICER_NAME: WILLIAMS, BENFEARD LEECHELLE

PROJECT_TERMS: Acute;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapy;Amyloid beta-Protein;Anesthesia procedures;Anesthetics;apolipoprotein E-4;APP-PS1;Behavior;Biology;Blood;Blood Cells;blood-brain barrier penetration;Brain;Brain Injuries;Capital;Capital Financing;Cells;cerebral atrophy;Certification;Clinical;clinical development;Clinical Research;Clinical Trials;commercialization;Data;Development;Disease;Disease associated microglia;Disease Progression;Dose;Drug Kinetics;efficacy clinical trial;efficacy study;efficacy trial;Evaluation;Feedback;Funding;Gases;genetic risk factor;Glaucoma;Goals;Health;healthy volunteer;Hospitals;Human;human induced pluripotent stem cells;human subject;Immune;Immune system;Impairment;improved;In Vitro;in vivo;Induction of Apoptosis;Infiltration;Inflammatory;Inflammatory Response;Inhalation;Inhalation Therapy;interest;Late Onset Alzheimer Disease;Legal patent;lipid biosynthesis;Microglia;Modeling;Molecular Profiling;monocyte;mouse model;Mus;Myeloid Cells;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neuroprotection;Neuroprotective Agents;neutrophil;novel;novel strategies;Pathogenicity;patient safety;Patients;Peripheral;Phagocytes;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;phase 1 study;Phase I Clinical Trials;phase I trial;Phase Ia Clinical Trial;Phase II Clinical Trials;Phenotype;Play;pre-clinical;pre-Investigational New Drug meeting;Preparation;preservation;Private Sector;programs;Published Comment;Regulation;response;restoration;Role;Safety;safety assessment;safety study;Senile Plaques;Signal Transduction;Small Business Technology Transfer Research;Tauopathies;Testing;therapeutically effective;timeline;tool;Transplantation;volunteer;Woman;Work;Xenon

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


NIH_SPENDING_CATS: Biotechnology;Cancer;Urologic Diseases

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE The development of accurate biomarkers for the non-invasive detection of bladder cancer (BC) will improve clinical treatment by reducing reliance on cystoscopy, which is burdensome for patients and expensive for healthcare providers, and by providing new information on tumor recurrence potential and response to drug therapy. Simplified CR culture systems and pre-analytic studies will facilitate clinical applications of urine cancer cell cultures (UCCC).

PI_NAMEs: LIU, XUEFENG  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, LOKESH

PROJECT_TERMS: Address;Affect;Antibiotics;Antibody-drug conjugates;Biological Markers;Bladder;cancer cell;Cancer Center;Cancer Detection;Cancer Patient;cancer recurrence;cancer type;Cell Count;Cell Culture System;Cell Culture Techniques;Cell model;Cell Survival;Cells;chemotherapy;Clinic;Clinical;clinical application;clinical assay development;Clinical Treatment;Clinical Trials;clinically relevant;Coculture Techniques;Collection;Conditioned Culture Media;contextual factors;cost;Cystoscopy;Data;Development;Diagnosis;drinking water;drug sensitivity;Early Diagnosis;Epithelial Cell Proliferation;European;Evaluation;evidence base;FDA approved;Freezing;Funding;Future;General Anesthesia;Goals;Health Personnel;high risk;Hypoxia;Immunotherapy;improved;Intravesical Instillation;invention;Laboratories;liquid biopsy;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Medical;member;Methods;Modeling;Monitor;Monitoring for Recurrence;mortality;Needle biopsy procedure;Non-Invasive Detection;Operative Surgical Procedures;patient response;Patients;Persons;Pharmacotherapy;predicting response;Procedures;Prognosis;protein kinase inhibitor;Proteins;Protocols documentation;Recurrence;Recurrent tumor;Relapse;response;rho;sample collection;Sampling;Specimen;Specimen Handling;Standardization;success;System;targeted treatment;Technology;Temperature;Testing;Therapeutic Agents;Time;Tissues;Transportation;Transurethral Resection;Treatment outcome;tumor progression;Urine;Urology;Variant;Work;X-Ray Computed Tomography

PROJECT_TITLE: Evaluation of Pre-Analytical Factors of Urine Samples for Urine Cancer Cell Cultures (UCCC) --A Non-Invasive Biomarker – in Monitoring Response and Recurrence of Bladder Cancer


ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: 2020 Overall Narrative The purpose of the Great Plains (GP) IDeA-CTR is to further develop key infrastructure and human resources to meet clinical and translational research (CTR) needs and health challenges across our network. To do so, the GP-IDeA CTR enhances existing partnerships across all Nebraska University system institutions (UNMC, UNO, UNL, and UNK) and Boys Town National Research Hospital, expands our network to include Creighton University, Children’s Hospital and Medical Center, and the Omaha Veterans Administration Medical Center; continues development of a community-anchored Practice-Based Research Network; and forges a new relationship with the DaCCoTA CTR to strengthen CTR connections with Dakota institutions. We continue to advance services and sustainable resources through our Cores (Administrative, Professional Development, Biostatistics, Community Engagement, Biomedical Informatics, Tracking and Evaluation, and Pilot Projects Program)––informed by challenges addressed and lessons learned from the first funding cycle; sharpen our silo-spanning thematic focus on team science plus community engagement to advance CTR teams and partnerships; and continue to emphasize innovation and entrepreneurship to catalyze movement across the CTR spectrum––leveraging engineering, medicine, and technology transfer expertise across the network to build capacity to bring community-relevant ideas to the marketplace.

PI_NAMEs: RIZZO, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Achievement;Address;Advisory Committees;Award;Basic Science;Bioinformatics;biomedical informatics;Biometry;boys;Caring;Centers of Research Excellence;Clinical Research;clinically relevant;Collaborations;Communities;community advisory board;community engagement;Community Health;Community Outreach;cyber infrastructure;Dedications;Development;early-career faculty;Engineering;Entrepreneurship;Environment;Epidemiology;Evaluation;experience;forging;Fostering;Funding;Geography;Goals;Great Plains;Health;Hospitals;Human Resources;improved;Infrastructure;innovation;Institution;Kansas;Lead;Leadership;Learning;Malignant Neoplasms;Medical center;Medicine;meetings;member;Movement;multidisciplinary;National Institute of General Medical Sciences;Nebraska;North Dakota;Outcome;Pediatric Hospitals;Pilot Projects;practice-based research network;Privatization;programs;Research;Research Design;Research Infrastructure;Research Personnel;Resource Sharing;Resources;response;Rural;rural area;Rural Community;rural underserved;Science;Services;Site;Social isolation;South Dakota;sustainable resource;System;Technology Transfer;tool;Translating;Translational Research;underserved urban area;United States Department of Veterans Affairs;Universities;Urban Community;Urban Developments;Vulnerable Populations

PROJECT_TITLE: Great Plains IDeA-CTR


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health

PROJECT_TERMS: Advisory Committees;authority;Back;Biomedical Research;Budgets;Centers of Research Excellence;Clinical Research;Collaborations;Communication;Communities;community advisory board;community partners;Core Facility;Development;Discipline;Elements;Ensure;Environment;Evaluation;experience;Feedback;flexibility;Funding;Goals;Great Plains;Health;Health Personnel;Improve Access;improved;Individual;Information Dissemination;Infrastructure;innovation;Institution;Laboratory Research;Leadership;Link;Measurable;meetings;member;Methods;National Center for Advancing Translational Sciences;National Institute of General Medical Sciences;operation;Outcome;Participant;Pathway interactions;Personnel Management;Phase;Policies;Practice Management;practice-based research network;Privatization;Problem Solving;Procedures;Program Evaluation;programs;Provider;Research;Research Personnel;Resources;Role;rural area;Rural Health;Science;Services;Site;Strategic Planning;Structure;success;Sum;Training;Translating;translational pipeline;United States National Institutes of Health;Work


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Rehabilitation

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: The present research is aimed at developing better techniques to improve cognitive control through neurostimulation in humans. Cognitive control is a fundamental cognitive ability whose impairment characterizes a large number of psychiatric diseases. Developing tools to improve it could lead to new treatments for diseases such as depression, post-traumatic stress disorder, addiction, and obsessive-compulsive disorder.

PI_NAMEs: HAYDEN, BENJAMIN Y;WIDGE, ALIK S. (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: addiction;Anatomy;Animal Model;Animals;Axon;Behavioral;Biological Models;Brain;Cell Nucleus;Clinical;clinical efficacy;clinical practice;Clinical Trials;Cognition;Cognitive;cognitive ability;cognitive control;cognitive neuroscience;Collaborations;Complex;Corpus striatum structure;Deep Brain Stimulation;Disease;Distal;Electrodes;Electrophysiology (science);Elements;Engineering;Fiber;Functional disorder;genetic manipulation;Goals;gray matter;Homologous Gene;Human;Impairment;Implant;improved;Individual;insight;Institution;Internal Capsule;Lateral;Macaca;Macaca mulatta;Maps;Mental Depression;Mental disorders;Methods;Modeling;Movement Disorders;Mus;neural;neural correlate;nonhuman primate;Obsessive-Compulsive Disorder;Patients;Pattern;Performance;Post-Traumatic Stress Disorders;Prefrontal Cortex;Primates;Process;Psychiatry;Rattus;Research;Research Domain Criteria;Research Personnel;Resolution;response;Rodent;Role;Running;Site;Structure;success;Techniques;Testing;Thalamic structure;tool;Ventral Striatum;ventral visual stream;Viral;white matter;Work

PROJECT_TITLE: Modeling circuit-specific psychiatric deep brain stimulation and its cognitive effects in macaques


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Roughly 6,000 new cases of stroke are admitted to the VA hospital system each year, and over half of these patients will experience long-term disability. Neuromodulation is a promising treatment avenue for enhancing recovery from stroke, but current approaches are limited by a limited understanding for how external stimulation interacts with brain dynamics. Here, I propose to (1) study how dynamics in a specific inhibitory network supports motor learning and recovery and (2) probe the impact of activating these inhibitory networks on learning and recovery. My goal is to discover fundamental principles for neural circuit plasticity that can be translated into more effective neuromodulation therapies for stroke patients.

PI_NAMEs: ARROYO, SERGIO ESTEVAN (contact)

PROJECT_TERMS: Address;Admission activity;Affect;Animals;Area;Brain;Calcium;calmodulin-dependent protein kinase II;career development;cell cortex;cell type;Cells;Clinical Trials;cohort;Complex;Data;design;disability;Electronic Medical Records and Genomics Network;Ensure;Environment;excitatory neuron;experience;Experimental Designs;experimental study;Functional disorder;functional improvement;Future;Goals;grasp;Hospitals;imaging system;improved;inhibitory neuron;injury recovery;insight;Investigation;kinematics;Laboratories;Learning;Left;Long term disability;long term recovery;Mentorship;Modification;motor behavior;Motor Cortex;motor function improvement;motor learning;motor recovery;Movement;neural circuit;Neurons;neurophysiology;neuroregulation;novel therapeutics;optogenetics;Patients;Pattern;Physicians;Population;Population Dynamics;post stroke;Preparation;Program Development;programs;Publications;Randomized;Reaction Time;Recovery;recruit;Reproducibility;Research;Research Personnel;San Francisco;Scientist;sex;skills;Stroke;stroke patient;stroke recovery;stroke therapy;support network;System;Testing;tool;Training;Translating;Veterans

PROJECT_TITLE: Modulating cortical inhibitory networks to improve stroke recovery

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Rural Health

PI_NAMEs: MIKULS, TED RICHARD (contact)

PROJECT_TITLE: Professional Development Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE We are witnessing explosive growth in new tests that can help detect cancer, predict whether it is likely to spread, and decide which treatments have the best chance of being effective. There are so many new tests that they cannot always be studied properly to make sure they actually improve patients’ lives. This research program aims to carefully combine all the available data to learn which new tests we should be recommending to the public.

PI_NAMEs: ETZIONI, RUTH D (contact)

PROGRAM_OFFICER_NAME: MARIOTTO, ANGELA B

PROJECT_TERMS: black men;Cancer Detection;Cancer Diagnostics;Cancer Patient;Caring;Characteristics;Clinical;Collaborations;Competence;Controlled Study;cost;Data;Diagnosis;Diagnostic;Diagnostic tests;Discipline;Disparity;Equity;Evaluation;FOLH1 gene;Generations;Growth;health care service utilization;high risk population;improved;interest;Knowledge;knowledge integration;Learning;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Informatics;Methodology;Modeling;new technology;Newly Diagnosed;novel;novel diagnostics;Outcome;Patients;Performance;performance tests;PET/CT scan;Phase;Policies;Positron-Emission Tomography;precision medicine;Principal Investigator;Process;programs;Recommendation;Recurrence;Research;screening;Screening for cancer;Screening for Prostate Cancer;screening guidelines;skills;statistical learning;Techniques;Technology;Testing;tool;Uncertainty;Update;uptake;Work

PROJECT_TITLE: Modeling and analytics for cancer diagnostics: traversing the data-evidence divide


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE . The goal of this project is to test the hypothesis is that the cAMP-dependent protein kinase (PKA) and mechanistic target of rapamycin complex-1 (mTORC1) activation cascade regulates salt-inducible kinase-3 (SIK3) as a phosphorylation ‘switch’ for β-adrenergic activation to drive the adipose tissue thermogenic gene program. The research aims of this project will (i) use genetic models of tissue-specific Sik3 knockout mice and Sik2/Sik3 double-knockout mice, and pharmacological studies with small molecule SIK inhibitors. (ii) Establish how mTORC1 inhibits SIK3 via its interaction with Raptor and phosphorylation at Ser884, and (iii) Test the hypothesis that class IIa HDACs, especially HDAC4, and CRTCs, in particular CRTC3, promotes thermogenic gene expression upon SIK3 inhibition.

PI_NAMEs: COLLINS, SHEILA  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: absorption;Adipocytes;Adipose tissue;Adrenergic Agents;Adult;Affect;Agonist;Amino Acids;Behavioral;beta-adrenergic receptor;Biogenesis;Biology;Body fat;Body mass index;Body Temperature;Brown Fat;Calories;Cardiometabolic Disease;cardiometabolic risk;Cardiovascular Diseases;Cell Culture Techniques;Cells;Chronic;Chronic Disease;cold temperature;Complex;Consumption;cost;Country;Critical Pathways;Cyclic AMP;Cyclic AMP Receptor Protein;Cyclic AMP-Dependent Protein Kinases;Data;Desire for food;diet-induced obesity;Disease;economic impact;Economics;Energy Metabolism;Epidemic;Event;experimental study;Fatty acid glycerol esters;Fatty Acids;FDA approved;FRAP1 gene;Gatekeeping;Gene Expression;Gene Expression Profile;Genes;Genetic Models;genetic signature;Genetic Transcription;genome-wide;Glucose;Goals;HDAC4 gene;Histone Deacetylase;improved;In Vitro;in vivo;Incidence;Individual;inhibitor;Insulin Resistance;insulin sensitivity;Isoproterenol;knock-down;Knockout Mice;Knowledge;Life Style;Link;link protein;Location;Medical;Metabolic Diseases;metabolic phenotype;metabolic respiration;Metabolic syndrome;Metabolism;Mitochondria;Modeling;Molecular;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Obesity;Obesity Epidemic;obesity treatment;overexpression;Overweight;p38 Mitogen Activated Protein Kinase;Pathway interactions;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;phosphoproteomics;Phosphorylation;Phosphorylation Site;Population;PPAR gamma;prevent;Production;programs;Proteins;Protons;Public Health;Quality of life;Receptor Activation;Receptor Signaling;recruit;Regulation;Research;Respiration;response;Risk;Rodent;Role;Safety;salt-inducible kinase;Signal Pathway;Signal Transduction;Sirolimus;small hairpin RNA;small molecule;Stable Isotope Labeling;Sympathetic Nervous System;Testing;Therapeutic;Tissue Model;Triglycerides;uncoupling protein 1;Work

PROJECT_TITLE: Role of SIK3 in PKA/mTORC1 regulation of adipose browning

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Networking and Information Technology R&D (NITRD);Rural Health

PI_NAMEs: ZHANG, YING  (contact)

PROJECT_TERMS: Address;Applications Grants;Area;bench to bedside;Big Data;Bioinformatics;biomedical informatics;Biometry;career;certificate program;Clinical Research;Collaborations;Communities;community engaged research;community engagement;Consult;cyber infrastructure;Data;data acquisition;Data Analyses;Data Analytics;Data Set;design;Development;Education;Educational workshop;Ensure;Epidemiologist;Epidemiology;Funding;Goals;Grant;Great Plains;health data;Health Priorities;Incubators;Infrastructure;innovation;Lead;member;Mentors;Methodology;Methods;novel;Paper;Participant;Pilot Projects;Play;Positioning Attribute;programs;Publishing;Reporting;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;response;Role;Science;Series;Services;Site;skills;sound;special interest group;Statistical Methods;success;summer institute;tool;Training;Training Activity;Training and Education;Training Support;Translational Research;translational research program

PROJECT_TITLE: Biostatistics, Epidemiology, and Research Design Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE Almost all biological/physiological processes such as sleep and physical activity levels display circadian rhythms (of ~24 h) that are regulated by the endogenous circadian system, and disrupted circadian rhythms are linked to many adverse health outcomes including increased risk for sleep disorders, cardiometabolic diseases, and dementia. Using the existing cohort of ReDLat (Multi-Partner Consortium to Expand Dementia Research in Latin America) and an unobtrusive assessment of circadian health, this project is proposed to examine the effects of age, sex, and socioeconomic factors on circadian function in Latinos, and the involvement of circadian disturbance in the characterization of two types of dementias (Alzheimer’s disease and frontotemporal lobar degeneration) in this underrepresented population. The project will help address Latino health disparities, provide a sustainable, scalable and equitable approach to circadian health monitoring and a non-invasive tool for assessment or identification of dementia, and lead insights into the relevance of circadian disturbance to the high and increasing prevalence of dementia in Latin American countries.

PI_NAMEs: HU, KUN  (contact);IBANEZ, AGUSTIN M.

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Acceleration;actigraphy;Address;Affect;Age;age effect;aged;Aging;aging process;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;amyloid pathology;apolipoprotein E-4;Assessment tool;Behavioral;Bereavement;Biological;Biological Markers;Biological Process;Cardiometabolic Disease;Cells;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Clinical;Clinical assessments;Cognition;cognitive function;cognitive performance;cohort;cost efficient;Country;Coupled;Data;Data Set;Databases;deep learning;Dementia;dementia risk;Devices;Diagnosis;Dimensions;Discrimination;Elderly;Enrollment;Environment;environmental change;Epidemiology;Equity;Ethnic Origin;Europe;experience;forging;Foundations;Fractals;Frontotemporal Lobar Degenerations;Functional Magnetic Resonance Imaging;Funding;Gender;Genes;Genetic;genetic variant;genome sequencing;genome wide association study;Goals;Health;health disparity;Health Services Accessibility;High Prevalence;human old age (65+);Impaired cognition;Income;Individual;Inequity;insight;Latin America;Latin American;Latino;Latino Population;Lead;Life Style;Link;longitudinal design;Magnetic Resonance Imaging;Measures;Metabolism;migration;mild cognitive impairment;Minority;Monitor;Motor Activity;multimodal data;multimodal neuroimaging;Nerve Degeneration;Neuroanatomy;Neurocognition;Neurocognitive Deficit;novel;Outcome;Participant;participant enrollment;Pattern;Periodicity;Physical activity;Physiological Processes;polygenic risk score;Population;Population Density;pre-clinical;Prevalence;prevent;Prevention;Public Health;Quality of life;Race;Research;Risk;risk prediction;Sampling;Series;sex;Sex Differences;shift work;Single Nucleotide Polymorphism;Site;Sleep;Sleep Disorders;Sleep Wake Cycle;Social Environment;social health determinants;Socioeconomic Factors;Socioeconomic Status;System;Testing;Underrepresented Populations;United States;United States National Institutes of Health;whole genome;wristband

PROJECT_TITLE: Circadian Disturbance and Dementia in Latin America

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: ESTABROOKS, PAUL  (contact)

PROJECT_TERMS: Address;Adopted;Area;Calendar;Clinical;Clinical and Translational Science Awards;clinical practice;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community advisory board;community based participatory research;community engaged research;community engagement;community organizations;Community Outreach;community partners;community-centered;Consultations;COVID-19;Data;Development;Diagnostic;dissemination science;Education;Educational workshop;Event;evidence base;Evidence based intervention;Extramural Activities;Funding;Goals;Grant;Great Plains;Health;health disparity;health equity;Health Priorities;Healthcare;implementation science;improved;Incubators;Infrastructure;innovation;Institution;Interest Group;Medical;meetings;member;Methodology;Mission;Modeling;Network Infrastructure;online resource;Outcome;outreach;Phase;population health;practice-based research network;pre-clinical;Prevention;Process;Production;Public Health;Registries;repository;Research;Research Personnel;Research Project Grants;Resources;Rural Population;scale up;Science;Services;Site;Social Justice;success;summer institute;System;tool;Training;training opportunity;translational pipeline;Translational Research;Underserved Population;Video Recording;web site;Work;Writing

PROJECT_TITLE: Community Engagement ane Outreach (CEO)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: NARRATIVE Understanding mechanisms underlying selective vulnerability from cells to networks in Alzheimer's disease (AD) is critical to define the disease process and to develop effective therapies. We present an innovative, multidisciplinary strategy to investigate factors underlying selective vulnerability, from brain cells to brain regions, across the AD spectrum, a high-priority topic of interest under PAR-22-093, NOT-AG-21-040. The outcomes are highly relevant insights, of both mechanistic and therapeutic importance.

PI_NAMEs: CHIOSIS, GABRIELA  (contact);CHU, FEIXIA ;GINSBERG, STEPHEN D

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Affinity Chromatography;Age;Aging;Alzheimer's Disease;Alzheimer's disease brain;Autopsy;axon guidance;Binding;Biochemical;Bioinformatics;Biological;Biology;Brain;brain cell;brain circuitry;Brain region;brain tissue;Cell Communication;Cell Cycle;Cell model;Cell Physiology;Cells;Cellular biology;Cerebellum;Clinical;Communities;Complement;Complex;conformer;connectome;crosslink;Data;Data Analytics;Data Set;Defect;Deposition;Development;Diagnostic;Disease;Disease Progression;effective therapy;Elements;Environmental Risk Factor;Event;Exposure to;frontal lobe;Functional disorder;Funding;Gender;Genetic;Genetic Predisposition to Disease;Heat-Shock Proteins 90;Hippocampus;Impaired cognition;Individual;Induced pluripotent stem cell derived neurons;Inflammation;innovation;insight;interest;Investigation;Link;Maps;Mass Spectrum Analysis;Measures;Mediating;member;Metabolism;Methods;Mining;Modification;Molecular Biology;Molecular Chaperones;Molecular Conformation;multidisciplinary;Multiprotein Complexes;Nature;network dysfunction;Neurodegenerative Disorders;Neuroglia;Neurons;novel;Outcome;Output;Pathologic;Pathway interactions;Patients;Phenotype;Post Translational Modification Analysis;Post-Translational Protein Processing;Process;protein protein interaction;Proteins;Proteome;proteotoxicity;scaffold;Site;spatiotemporal;Specificity;Stress;stressor;structural determinants;Structure;Synaptic plasticity;System;Testing;Therapeutic;therapeutic development;Transgenic Mice;Translations;Validation

PROJECT_TITLE: Selective interactome vulnerability across the Alzheimer’s disease spectrum

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Sexually Transmitted Infections;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PUBLIC HEALTH RELEVANCE This study will enhance essential HIV prevention services and increase our understanding of how to sustain critical HIV prevention services over time in Nigeria. The project draws on the unique strengths of Nigerian youth to develop youth-inspired sustainment strategies and evaluate how to sustain components of the 4 Youth By Youth (4YBY) program for HIV uninfected at-risk youth. This study will help inform the sustainment of HIV prevention strategies that reduce the acquisition of HIV in at-risk youth living in resource constrained settings in low- and middle-income countries (LMICs).

PI_NAMEs: EZECHI, OLIVER CHUKWUJEKWU;IWELUNMOR, JULIET  (contact);TUCKER, JOSEPH DAVID

PROGRAM_OFFICER_NAME: LEE, SONIA S

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescent;Adolescent and Young Adult;Adoption;Affect;Africa;aged;AIDS prevention;American;Area;Chlamydia;Clinic;Clinical Services;cohort;Collaborations;community based participatory research;Comprehensive Health Care;Consolidated Framework for Implementation Research;Continuity of Patient Care;cost effectiveness;cost estimate;cost per quality-adjusted life year;cost-effectiveness ratio;Creativeness;crowdsourcing;Data;design;Diagnostic Reagent Kits;discrete data;disparity reduction;Economic Models;Effectiveness;effectiveness evaluation;Elements;Eligibility Determination;evidence base;experimental study;follow-up;Friends;Funding;General Population;Gonorrhea;hackathon;Health;Hepatitis;Hepatitis B Virus;high risk;HIV;HIV Infections;HIV risk;HIV Seronegativity;Human immunodeficiency virus test;Hybrids;implementation barriers;implementation outcomes;implementation science;implementation strategy;improved;incremental cost-effectiveness;innovation;Interdisciplinary Study;Intervention;Investigation;learning community;Local Government;low and middle-income countries;Maintenance;Methods;Modality;Modeling;Monitor;National Institute of Child Health and Human Development;National Institute of Mental Health;Nigeria;Nigerian;Outcome;peer support;Persons;pilot trial;pre-exposure prophylaxis;Prevention;Prevention program;prevention service;Prevention strategy;preventive intervention;primary outcome;Proctor framework;programs;public health relevance;Quality-Adjusted Life Years;Randomized, Controlled Trials;recruit;Research;Research Priority;research study;research to practice;Resource-limited setting;Risk;secondary outcome;self testing;Services;Sexually Transmitted Diseases;Site;success;Supervision;Syphilis;Techniques;Testing;testing services;Time;tool;Training;UNICEF;United States National Institutes of Health;uptake;Work;Youth

PROJECT_TITLE: Sustaining Innovative Tools to Expand Youth-Friendly HIV Self-Testing (S-ITEST)


PI_NAMEs: HOLSTEIN, SARAH A (contact)

PROJECT_TERMS: Address;Age-associated memory impairment;aging related;Award;behavioral health;Biometry;Cardiovascular Diseases;care systems;Clinical;clinical care;Clinical Research;Collaborations;Communities;community advisory board;community engagement;Community Health;Community Outreach;Community Services;Data;Data Science;design;Development;Disease;Disparity;Education;Entrepreneurship;Epidemiology;Ethnic Origin;Evaluation;Extramural Activities;Faculty;Financial Support;Fostering;Funding;Funding Mechanisms;Funding Opportunities;Geography;Goals;Grant;Great Plains;Health;health disparity;Health Priorities;improved;injury prevention;innovation;Institution;Intellectual Property;inter-institutional;Legal patent;Malignant Neoplasms;Manuscripts;medical specialties;Mental Health;Mentors;Modeling;Nebraska;novel;obesity prevention;obesity treatment;Oral;Outcome;Pilot Projects;Privatization;Productivity;programs;Publishing;Race;Recommendation;Research;Research Design;Research Personnel;Research Project Grants;Resources;Rural Population;Science;social determinants;Substance abuse problem;success;Techniques;Technology;tool;Training;Translational Research;translational research program;Translations;trial design;Violence;Work;Writing

PROJECT_TITLE: Pilot Projects Program


PI_NAMEs: PHILIBERT, INGRID  (contact)

PROJECT_TERMS: Address;Affect;Age-associated memory impairment;aging related;Area;behavioral health;Budgets;care systems;Charge;Clinical;clinical care;Clinical Research;collaborative approach;commercialization;Communities;community advisory board;Community Health;Community Services;Competence;Complex;Data;Data Collection;Decision Making;design;Development;Economics;Effectiveness;effectiveness evaluation;effectiveness research;Elements;Ensure;Environment;Ethnic Origin;Evaluation;Feedback;Fostering;Funding;Geography;Goals;Great Plains;Health;health care delivery;health disparity;Health Priorities;Impact evaluation;improved;Individual;injury prevention;innovation;Institution;Knowledge;Leadership;meetings;member;Mental Health;Methods;Modeling;Movement;novel;Obesity;obesity in children;Outcome;Outcomes Research;Performance;Phase;Pilot Projects;Policies;Population;population health;Process;Productivity;programs;Progress Reports;Public Health;Race;Reporting;repository;Research;Research Activity;Research Priority;Resources;Science;Services;social determinants;Strategic Planning;Substance abuse problem;success;System;Technology;tool;translational pipeline;Translational Research;translational research program;Violence;Work

PROJECT_TITLE: Tracking and Evaluation Core


ADMINISTERING_IC: HG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Recent advances in precision medicine have accelerated research in rare diseases and overwhelmed clinicians’ capacities to manage and leverage the latest knowledge efficiently in clinical practice. This project will build a novel informatics framework that leverages semantic knowledge discovery and data mining techniques to assist rare disease differential diagnoses with the goal of shortening the diagnostic odyssey associated with rare diseases.

PI_NAMEs: LIU, HONGFANG  (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Academic Medical Centers;Acceleration;accurate diagnosis;Address;Affect;American;Asthma;Awareness;base;biomedical informatics;Cardiovascular Diseases;Characteristics;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;clinical practice;cohort;Collaborations;Consumption;cost;Data;Data Analyses;data mining;Databases;Development;Diagnosis;Diagnostic;Differential Diagnosis;Disease;Disseminated eosinophilic collagen disease;Electronic Health Record;empowerment;experience;Face;Feedback;Gene Mutation;Genomic medicine;Goals;Graph;graph neural network;Growth;Health Personnel;Heart Diseases;Human;idiopathic pulmonary fibrosis;improved;Individual;Informatics;informatics infrastructure;Information Management;Information Resources;interest;Kidney Calculi;Knowledge;Knowledge Discovery;knowledge hub;language training;Learning;Literature;Manuals;mastocytosis;Medical Records;Methods;Mining;Modeling;mRNA Differential Displays;Natural Language Processing;novel;Patients;Phenotype;Physicians;Play;pragmatic implementation;precision medicine;programs;Rare Diseases;Recommendation;Records;Research;Research Personnel;Resources;Respiratory Disease;Role;scale up;Science;Semantics;Source;Symptoms;System;Techniques;technological innovation;Testing;text searching;Time;tool;Training;Translations;Validation;web based interface;web portal

PROJECT_TITLE: Learning Precision Medicine for Rare Diseases Empowered by Knowledge-driven Data Mining

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Genetics;Mental Health;Mental Illness;Neurosciences;Pediatric;Social Determinants of Health;Substance Misuse;Suicide;Underage Drinking

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Alcohol use/problems is widespread in the US and have substantial public health consequences. Alcohol problems lead to adverse outcomes such as suicidal thoughts and behaviors (STB). Preliminary evidence in adolescents also suggests that subclinical alcohol measures are associated with STB. By combining genetics and neuropsychology, this K99/R00 proposal offers an advanced understanding of the underlying mechanisms involved in alcohol use/problems and STB comorbidity according to the influence of genes and environment, in both adolescent and clinical samples.

PI_NAMEs: LANNOY, SEVERINE PATRICIA (contact)

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: Adolescence;Adolescent;Adult;adverse outcome;Affective;Alcohol abuse;Alcohol consumption;alcohol use disorder;Alcohols;Behavior Control;Behavioral Genetics;career;Characteristics;Clinical;Cognitive;cognitive control;cognitive system;comorbidity;Data;Decision Making;Development;Dimensions;disability;Discipline;Disinhibition;drinking behavior;drinking onset;early adolescence;early life adversity;economic cost;Emotional;Environment;Environmental Risk Factor;Equation;Etiology;Evaluation;Feeling suicidal;Foundations;Funding;General Population;Genes;Genetic;genetic information;Genetic Models;Genetic Risk;Goals;Health;hedonic;Heritability;high reward;Human;Impairment;improved;Impulsivity;Individual;insight;interest;Intervention;Investigation;Knowledge;Lead;Leadership;Measures;Mediating;Medical;Mentorship;Methods;Mission;Modeling;National Institute on Alcohol Abuse and Alcoholism;neural circuit;Neurocognitive;Neurocognitive Deficit;Neuropsychology;Other Genetics;Pathway interactions;Patient Self-Report;Phenotype;Play;Population;Prevalence;Prevention;Principal Investigator;Problem behavior;Process;programs;promote resilience;psychogenetics;psychologic;Public Health;Reporting;Research;Rewards;Risk Behaviors;Role;Sampling;Series;Severities;Specific qualifier value;Statistical Methods;Stressful Event;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;System;Testing;Training;Treatment outcome;underage drinking;Virginia

PROJECT_TITLE: Dissecting the co-occurrence of alcohol use/problems and suicidal behaviors: the roles of genetic liability and neurocognitive mechanisms

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Precision Medicine;Rural Health

PI_NAMEs: GUDA, CHITTIBABU  (contact)

PROJECT_TERMS: Adopted;Agreement;Area;biobank;Bioinformatics;biomedical informatics;Center for Translational Science Activities;Centers of Research Excellence;Certification;Child Health;Clinical;Clinical Data;Clinical Informatics;clinical infrastructure;clinical practice;Clinical Research;clinically relevant;cohort;Collaborations;Collective Bargaining;Community Health;Core Facility;COVID-19;Creativeness;cyber infrastructure;Data;data access;Data Analyses;Data Collection;Data Correlations;data integration;data resource;data sharing;Decision Support Systems;density;design;Development;Diagnostic;Disease;Dissemination and Implementation;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Electronic Health Record;Environment;Feasibility Studies;Funding;Genetic;genomic data;Genomics;Goals;Great Plains;Health;health data;Healthcare;healthcare community;heterogenous data;Home;Hospitals;Human Resources;Individual;Informatics;informatics infrastructure;informatics tool;Infrastructure;innovation;Institution;interoperability;Knowledge;Link;liquid biopsy;Machine Learning;member;Mentors;Mission;mobile application;Molecular;Monitor;Nebraska;next generation sequencing;novel diagnostics;operation;Outcome;Outcomes Research;personalized health care;Physicians;Population;Precision Health;precision medicine;prognostic;programs;Protocols documentation;public education;Public Health Informatics;Registries;Research;Research Activity;Research Personnel;Resource Informatics;Resource Sharing;Resources;Rural Population;Sampling;Science;Services;success;support tools;Technical Expertise;Technology;telehealth;tool;Training;Training Activity;Training Programs;Translational Research;Underserved Population;wearable device;web portal

PROJECT_TITLE: Biomedical Informatics, Bioinformatics, and Cyberinfrastructure Enhancement Core


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Cancer;Endocrine Disruptors;Foodborne Illness;Genetics;Human Genome;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE In the U.S. and around the world, millions of people are exposed to arsenic in their drinking water, a known human carcinogen. This study will investigate if arsenic exposure in early-life alters epigenetic biomarkers of aging and disease risk decades later, that could help target prevention efforts during critical windows of development. This work will characterize the impact of early-life arsenic exposure on epigenetic biomarkers of disease susceptibility and mortality decades later in adulthood.

PI_NAMEs: CARDENAS, ANDRES  (contact);DE LA ROSA, ROSEMARIE

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;Address;Adult;Age;age related changes;age-related disease;aging biomarker;Area;Arsenic;Biochemical;Biological;Biological Aging;Biological Markers;Biological Process;Birth;Blood specimen;Body mass index;Bronchiectasis;Carcinogens;Cardiovascular Diseases;Cells;Chile;Chronic Disease;Chronic Kidney Failure;Chronology;Cities;clinically relevant;cohort;contaminated drinking water;Data;Development;Diabetes Mellitus;Diet;Disease;Disease susceptibility;disorder risk;DNA Methylation;drinking water;Dyslipidemias;early childhood;early detection biomarkers;Early identification;early life exposure;Environmental Risk Factor;epidemiology study;epigenetic aging;epigenetic clock;epigenetic marker;Epigenetic Process;Exposure to;follow-up;frailty;Genes;Health;Health behavior;Human;human data;Human Genome;Immune;Immune system;immunoregulation;Impaired cognition;in utero;Incidence;Individual;Inflammation;Insulin Resistance;Investigation;Leukocytes;Life;life span;Link;Long-Term Effects;Longevity;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measurement;Measures;middle age;Monitor;Morbidity - disease rate;mortality;mortality risk;Myocardial Infarction;Natural experiment;Participant;Persons;Plants;Population;prenatal exposure;Prevention;programs;prospective;Records;Renal Carcinoma;Reporting;respiratory;Respiratory Disease;Respiratory Signs and Symptoms;Rest;Risk;Sampling;sex;Site;Smoking;Socioeconomic Status;Somatic Cell;Source;Systems Development;Testing;Tissues;Toxic effect;United States;urinary;Variant;Water;water treatment;Work;World Health Organization

PROJECT_TITLE: Programming of Epigenetic Clocks and Biomarkers from Early-life Arsenic Exposure

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Genetics;Nutrition;Obesity

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Rising incidence of obesity has drawn attention to the importance of adipose tissues in energy metabolism and pathogenesis of obesity. We have identified FHL1 as a novel mediator of adipose development. Investigations into adipose FHL1 functions would increase our understanding of obesity and potentially lead to novel therapies.

PI_NAMEs: ANOKYE-DANSO, FREDERICK  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: 15 year old;adipocyte differentiation;Adipocytes;adipokines;Adipose tissue;Agreement;Amino Acid Substitution;Animal Model;Applications Grants;Attention;Attenuated;Biochemistry;Biological Process;Biology;blood glucose regulation;boys;Bypass;Cardiomyopathies;Case Study;Cell Differentiation process;Cell model;Cells;Cellular biology;Compensation;Data;Development;diet-induced obesity;Elements;energy balance;Energy Metabolism;Enzymes;Exhibits;experimental study;FHL1 gene;FHL2 gene;Fibroblasts;Functional disorder;Gene Expression;Genes;glucose metabolism;Goals;High Fat Diet;Homeostasis;Human;Hypertrophy;Impairment;In Vitro;in vivo;in vivo evaluation;Incidence;insight;insulin sensitivity;Investigation;knock-down;Knock-out;Knockout Mice;LIM Domain;Link;lipid biosynthesis;lipid metabolism;loss of function;Luciferases;Mediating;Mediator;member;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Mitotic Cell Cycle;Molecular;Molecular Biology;mouse model;Mus;Muscle;Muscular Dystrophies;Myocardium;N-terminal;novel;novel therapeutic intervention;novel therapeutics;Obesity;older patient;overexpression;paralogous gene;Pathogenesis;Pathway interactions;Patients;Phenotype;Physiological;Positioning Attribute;postnatal;Principal Investigator;Protein Family;Protein Isoforms;protein protein interaction;Proteins;Regulation;Reporting;Research;Research Personnel;Resistance;Role;Serine;Signal Transduction;Skeletal Muscle;subcutaneous;transcription factor;Transcriptional Regulation;transplant model;Tryptophan;Vertebral column

PROJECT_TITLE: Adipose FHL1 in energy homeostasis


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Stroke

PHR: Narrative The proposed methods will enable scientists and clinical investigators to tackle questions with imaging datasets that could not be properly analyzed previously. This will directly improve the research capabilities of thousands of clinicians and science investigators of human disease. This will lead to a sustained positive impact in basic and clinical research.

PI_NAMEs: DALCA, ADRIAN  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Address;Age;Anatomy;Basic Science;Bayesian Modeling;Biological;brain magnetic resonance imaging;cerebrovascular;Clinical;clinical care;clinical imaging;Clinical Investigator;Clinical Research;cohort;Collection;Computer software;Data;Data Set;deep learning;deep neural network;design;Development;Disease;Disease Pathway;Drug Targeting;experience;heterogenous data;human disease;Image;Image Analysis;image registration;imaging Segmentation;improved;insight;Knowledge;Label;Learning;Lesion;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;Manuals;Maps;Medical Imaging;Methods;Modality;Modeling;Morphologic artifacts;Motion;Multimodal Imaging;multimodality;neural network;Noise;novel;open source;open source tool;Output;Phenotype;Physics;Predisposition;Process;Protocols documentation;Qualifying;Race;Recording of previous events;Research;Research Personnel;Resolution;Resources;Scanning;Science;Scientist;sex;Site;skills;Source;Source Code;Speed;Stroke;stroke outcome;Stroke prevention;success;System;Techniques;Testing;Therapeutic Intervention;tool;Training;training data;Treatment Efficacy;validation studies;Variant;white matter;White Matter Hyperintensity;Work

PROJECT_TITLE: Fast and Robust Deep Learning for Medical imaging: Segmentation and Registration methods invariant to contrast and resolution

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Osteogenesis Imperfecta;Pediatric;Rare Diseases

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Osteogenesis Imperfecta is the most common human bone dysplasia presenting with recurrent fractures. We have shown blocking TGFβ is an effective treatment, but not all OI patients and mouse models respond. Hence, we plan to study the effectiveness of bone-targeted therapies and mechanisms for its increase.

PI_NAMEs: BAE, YANGJIN  (contact);LEE, BRENDAN

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Adult;Affect;angiogenesis;Antibodies;Architecture;Binding;Biomechanics;bisphosphonate;bone;Bone callus;Bone Development;bone fracture repair;bone mass;bone repair;bone turnover;Child;Chondrocytes;Clinical;Clinical Management;Clinical Trials;COL1A1 gene;COL1A2 gene;Collagen;Collagen Type I;combinatorial;Coupling;crosslink;Data;decorin;Developmental Bone Diseases;Dose;effective therapy;effectiveness study;Extracellular Matrix;FDA approved;fetal;Forteo;Fracture;Frequencies;Future;Genes;Genetic;Goals;healing;Histology;Human;Hydroxylation;Impaired healing;improved;Incidence;Inflammation;inflammatory marker;Inherited;innovation;Lead;Leucine;Long-Term Effects;Measures;mineralization;Modeling;Modification;mouse model;Mus;Mutation;neoplastic cell;new therapeutic target;novel therapeutics;off-label use;Osteoblasts;Osteoclasts;Osteogenesis;Osteogenesis Imperfecta;Outcome;overexpression;Participant;Pathway interactions;Patients;Phase;phase I trial;Phenotype;Physiologic Ossification;Procollagen;protein complex;Proteoglycan;Rattus;receptor;Recurrence;Regimen;Safety;safety testing;Sampling;Serology;Severities;Signal Transduction;skeletal;standard of care;targeted treatment;Testing;Therapeutic;Thick;Tibial Fractures;Toxicology;trafficking;Transforming Growth Factor beta;Type I Procollagen;United States National Institutes of Health;Vertebral column

PROJECT_TITLE: Targeting TGFb In Osteogenesis Imperfecta

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative A great need currently exists for medical devices specifically designed and labeled for children due to several unique challenges in this area. The UCSF-Stanford Pediatric Device Consortium (PDC) will leverage the team’s established device innovation talent and resources developed over the last decade, additional resources from participating institutions, and an unsurpassed entrepreneurial network in the region to provide total product life cycle support to pediatric device innovators. During this process, the PDC will maintain a commitment to diversity, equity, and inclusion to facilitate the translation of device innovations into high-value, commercially viable products which truly serve all pediatric populations.

PI_NAMEs: LEE, HANMIN  (contact)

PROGRAM_OFFICER_NAME: MEASE, CATHERINE A


ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PI_NAMEs: FINKEL, JULIA COLE (contact)

PROGRAM_OFFICER_NAME: JOHNSON, LLOYD

PROJECT_TITLE: Alliance for Pediatric Device Innovation


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Pediatric

ORG_CITY: SEATTLE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Narrative: This project will develop methods for mortality estimation for countries that have limited reporting systems, with detailed models being produced for subnational child mortality and for excess mortality in the Covid-19 pandemic. With respect to child mortality, two key uses of the estimates are: (i) the assessment of whether Sustainable Development Goals (SDGs) are being attained, and (ii) identifying subnational areas that require public health interventions. For excess mortality, the estimates can be used to understand the space- time dynamics of the disease, and inform on the success of public health measures, so that the world is better prepared as the pandemic continues, or as new pandemics emerge.

PI_NAMEs: WAKEFIELD, JONATHAN C (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Accounting;Address;Adopted;Age;Area;Bayesian Modeling;Benchmarking;Birth;Birth History;Caring;Censuses;Cessation of life;Child;Child Mortality;Childhood;Collaborations;complex modeling;Computer software;computing resources;Country;COVID-19 pandemic;Data;Data Collection;data modeling;Data Reporting;Data Sources;data streams;Death Rate;Decision Making;Dedications;design;Development;discrete data;Disease;Disparate;Disparity;Elements;Event;Excess Mortality;Exercise;flexibility;Geography;global health;Goals;Guidelines;Health;Household;Individual;interest;Intervention;Link;low and middle-income countries;Manuscripts;Measures;Methodology;Methods;Modeling;mortality;Mothers;Neonatal Mortality;new pandemic;novel strategies;open source;pandemic disease;Paper;Peer Review;Population;predictive modeling;Procedures;Process;Production;Public Health;public health intervention;Publishing;Reporting;Reproducibility;Reproducibility of Results;Research Personnel;response;sex;Software Validation;Statistical Methods;Stratification;success;Surveys;Sustainable Development;System;temporal measurement;theories;Time;Training;Translations;Twitter;Uncertainty;United Nations;Update;user friendly software;Walking;web site;Work;World Health Organization

PROJECT_TITLE: Bayesian Mortality Estimation from Disparate Data Sources

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Very few devices are developed, tested, and approved specifically for children due to a number of financial, technical, and other barriers. The Consortium for Technology & Innovation in Pediatrics proposes to build on 10 years of success and continue accelerating pediatric device innovation through collaboration and support.

PI_NAMEs: BAR-COHEN, YANIV ;BENT, MELISSA ;ESPINOZA, JUAN  (contact)

PROJECT_TITLE: The Consortium for Technology & Innovation in Pediatrics: CTIP 3.0


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Maternal Health;Pediatric;Pregnancy;Prevention;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: GREENVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: EAST CAROLINA UNIVERSITY

PHR: PROJECT NARRATIVE The establishment of oral health in pregnant women can have a lasting impact on their own oral health and their children's through their lifespan. This project will build the infrastructure for future interventions that incorporate the voices of pregnant women to build effective messages for oral health education to prevent oral diseases potentially decreasing the expenses on children's dental treatment. The successful completion of this project will collect evidenced data to develop a preventive program to decrease prevalence of early childhood caries.

PI_NAMEs: PARDI, VANESSA  (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: 5 year old;Address;Adopted;Adoption;Affect;aged;Applications Grants;base;Behavior;behavior change;burden of illness;Caring;Child;Child Health;Childhood;Chronic Disease;Communication;Communities;community based participatory research;County;Data;Dental;Dental Care;Dental caries;Dentists;design;Development;Discipline of obstetrics;Disease;disparity elimination;early childhood;Education;Environment;evidence base;experience;Face;Family;family support;Fostering;Future;Gingivitis;Goals;Health;Health behavior;health care availability;Health education;Health Personnel;Healthcare;improved;Infant;Infrastructure;innovation;Intervention;Interview;Knowledge;Life;life span;Location;Low Birth Weight Infant;Low income;Medicaid;Methods;Midwife;Monitor;motherhood;Mothers;Mouth Diseases;National Institute of Dental and Craniofacial Research;North Carolina;Occupations;Oral health;Outcome;Pain;Parents;Participant;pedagogy;perinatal period;Periodontitis;Persons;Photography;Play;Policies;Population;Postpartum Period;Pre-Eclampsia;Pregnancy;pregnant;Pregnant Women;Premature Birth;prenatal;Prevalence;prevent;Prevention;Preventive;Preventive dental care;preventive intervention;Process;programs;Provider;Recording of previous events;Research;Research Technics;response;Risk;Risk Assessment;Role;Rural;Sampling;Schools;social health determinants;System;theories;Time;United States National Institutes of Health;US State;virtual delivery;Visit;Voice;Woman;Women's Health

PROJECT_TITLE: Overcoming early childhood caries disease burden through the words of mothers (WOM project)

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative This proposal aims to develop a novel ultrafast sintering (UFS) technology to optimize the optical and mechanical properties of next-generation dental zirconia for chairside, labside, and centralized milling applications. This goal will be accomplished via the optimization of zirconia microstructures using fail-fast high- throughput approaches in conjunction with advanced materials characterization techniques. Knowledge generated from the study will open up avenues for applications of UFS in health care, as well as in broader fields of science and engineering.

PI_NAMEs: HU, LIANGBING ;ZHANG, YU  (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TITLE: Ultrafast sintering of dental zirconia: composition-processing-property relationships with high-throughput fail-fast screening

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ORG_DEPT: UROLOGY

PHR: Project Narrative: The Southwest National Pediatric Device Innovation Consortium’s goals are to utilize a multi-disciplinary network of stakeholders at Texas Children’s Hospital/Baylor College of Medicine and affiliated institutions and local device development partners in the Southwest/Midwest U.S. regions, as well as regional business and investment communities, to provide pediatric device innovators with product and technology acceleration services and business acceleration services to promote the development of pediatric devices that address critical unmet needs through the consortium’s extensive advisory network as well as direct device funding. It is anticipated that public health will benefit from the sustainable and productive needs-driven pipeline of new pediatric devices that will arise from consortium assistance given to pediatric device innovators at all stages, allowing devices to progress toward commercialization and clinical implementation.

PI_NAMEs: FISCHER, GWENYTH A;HARIDAS, BALAKRISHNA ;KOH, CHESTER  (contact);WETTERGREEN, MATTHEW ;WILLSON, RICHARD

PROJECT_TITLE: Southwest National Pediatric Device Innovation Consortium (SWPDC)


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Precision Medicine;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Analysis of real world data for risk assessment or comparative effectiveness research requires creation of cohorts that are clinically similar with the exception of the characteristic(s) being evaluated. Results may be confounded by systematic difference in the characteristics of patients assigned to the compared cohorts. The Similarity Matching In Longitudinal Electronic Patient Data (SMILE PD) project will apply a sophisticated patient matching algorithm within an easy-to-use interface to help Investigators to create suitable analytical cohorts to enable generation of accurate, reproducible real world evidence from the rich content of the All of Us data.

PI_NAMEs: WEINER, MARK G (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Affinity;Algorithms;All of Us Research Program;biobank;Caring;Cells;Characteristics;Chemical Structure;Chronic Disease;Clinical;Clinical Data;cohort;comorbidity;Comparative Effectiveness Research;Computational algorithm;Computerized Medical Record;Consumption;Data;Data Set;Data Sources;demographics;Diagnosis;Disease;Disease Outcome;DNA;effectiveness evaluation;Electronics;endophenotype;Environmental Risk Factor;Etiology;Evaluation;Generations;Genetic;genome wide association study;genomic data;Genomics;Goals;Healthcare;Heart failure;Hospitalization;Hypothyroidism;improved;Individual;Information Resources;interest;Investigation;Learning;learning algorithm;learning strategy;lifestyle factors;Link;Location;Manuals;Measures;Medical;Mental Depression;Mental disorders;Modeling;Non-Insulin-Dependent Diabetes Mellitus;Observational Study;open source;Outcome;Patient-Focused Outcomes;Patients;Peripheral arterial disease;Pharmaceutical Preparations;Phenotype;Population;precision medicine;Predictive Analytics;Predisposition;Prevention strategy;Process;Public Health Informatics;Records;Reproducibility;Research;Research Personnel;Resources;Risk;Risk Assessment;side effect;Smiling;sound;Specific qualifier value;Time;trait;treatment strategy;United States National Institutes of Health;vector;Visualization;Work

PROJECT_TITLE: SMILE-PD: Similarity Matching In Longitudinal Electronic Patient Data


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Neurosciences;Pain Research;Precision Medicine;Prevention;Social Determinants of Health;Substance Misuse

PHR: Project Narrative Substance use disorders and chronic pain frequently co-occur, yet the mechanisms driving their comorbidity are poorly understood. This application proposes to leverage whole genome sequence data and electronic health records data on chronic pain (including its subtypes) and substance use disorders (alcohol, tobacco, cannabis, and opioids) to better understand their relationship across multiple domains (phenotypic, genomic, biological overlap) and all represented ancestry groups in the All of Us program. The findings from this proposal will inform our understanding of the relationships between SUDs and chronic pain and eventually lead to improved treatment and prevention efforts.

PI_NAMEs: JOHNSON, EMMA COVEY (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: addiction;Affect;Alcohol consumption;alcohol use disorder;Alcohols;All of Us Research Program;ancestry analysis;Automobile Driving;Binding;biobank;Biological;biomarker identification;biopsychosocial;Brain;Cannabis;causal variant;Chromosome Mapping;Chronic;chronic pain;chronic pain management;clinical pain;cohort;comorbidity;cost;Data;Data Analyses;Development;Diagnosis;Discrimination;Disease;Early Intervention;Electronic Health Record;Ensure;Equation;Equity;ethnic minority;Etiology;European ancestry;experience;Family;Gender;gene network;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic study;genetic variant;Genetic Variation;genome analysis;genome wide association study;genomic data;genomic locus;Genomics;harassment;Heritability;Immunologics;improved;Individual;Lead;Life;Link;low socioeconomic status;Maps;marijuana use disorder;Measures;Mediating;Mediator;Mental Depression;Modeling;Morbidity - disease rate;Musculoskeletal;Musculoskeletal Pain;Nature;Neurologic;Neurons;Neuropathy;Nociception;novel;Opioid;opioid use disorder;Outcome;Pain;Pain management;Pain Research;Pathway Analysis;Pathway interactions;perceived discrimination;Phenotype;phenotypic data;pleiotropism;Population;Postoperative Pain;Prevention;psychosocial;Psychosocial Factor;Public Health;racial minority;rare variant;Recovery;Reporting;response;Rewards;Risk;Risk Factors;risk variant;Role;rural area;Sample Size;Sampling;Self Medication;Social Environment;social health determinants;socioeconomics;socioenvironmental factor;soft tissue;Source;substance use;Substance Use Disorder;Surveys;System;Testing;Tobacco;Tobacco Use Disorder;United States;Variant;Visceral;Visceral pain;whole genome;Woman;Work

PROJECT_TITLE: Using genomics and extensive phenotyping to dissect the relationships between substance use disorders and chronic pain


ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: Narrative / Public Health Relevance Statement The Midwest Pediatric Device Consortium (MPDC) will provide critical funding as well as business, legal, organizational, clinical, engineering and scientific resources to innovators for creation of pediatric medical devices having significant commercial potential and that improve healthcare for children.

PI_NAMEs: CRISS, CORY  (contact);ECKMANN, DAVID M

PROGRAM_OFFICER_NAME: PIAO, YUNSHANG


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Current treatments for cervical precancer among women living with HIV (WLWH) are limited by high rates of treatment failure. I propose a pilot study to generate preliminary data on the feasibility of self-administered artesunate vaginal inserts as adjuvant therapy to improve treatment outcomes among HPV+ WLWH in LMICs.

PI_NAMEs: MUNGO, CHEMTAI  (contact)

PROGRAM_OFFICER_NAME: SAHASRABUDDHE, VIKRANT V

PROJECT_TERMS: Ablation;Accounting;Adherence;Adjuvant;Adjuvant Therapy;Anus;Apoptosis;Area;arm;Artemisinins;artesunate;Biopsy;cancer cell;Cell Death;Cells;Cervical;cervical cancer prevention;Cervical Intraepithelial Neoplasia;Clinic;Clinical Trials;co-infection;Collaborations;cost effective;Coupled;cytotoxic;cytotoxicity;Data;Dyes;efficacy study;efficacy trial;eligible participant;Enrollment;Epithelial Cells;Excision;Exhibits;experience;Face;Failure;Feasibility Studies;follow-up;Free Radicals;Future;Genotype;Grant;Health;Hela Cells;high risk population;Histologic;HIV;HIV Seronegativity;HIV Seropositivity;HPV positive;HPV-High Risk;Human papilloma virus infection;Human Papillomavirus;improved;in vivo;Incidence;Individual;innovation;Intervention;Interview;Investigation;Iron;Kenya;Laboratories;Laboratory Finding;Lesion;low and middle-income countries;Malaria;Malignant neoplasm of cervix uteri;Measures;Medical Research;Men's Role;Methods;mortality;Normal Cell;Oncoproteins;overexpression;oxidative damage;Participant;participant enrollment;Patient Self-Report;Pharmaceutical Preparations;Phase;phase I trial;Pilot Projects;Placebos;Population;premalignant;Prevention strategy;Protocols documentation;Public Health;Randomized;randomized placebo controlled trial;Reaction;Recommendation;recruit;Recurrence;Research Institute;Risk;Safety;screening;Secondary Cancer Prevention;Secondary Prevention;Self Administration;Testing;TFRC gene;Thermal Ablation Therapy;Topical application;Treatment Failure;Treatment outcome;Trypan Blue;Ultraviolet Rays;uptake;Vagina;Vulva;Woman;women's treatment;Work;World Health Organization

PROJECT_TITLE: Feasibility of artesunate to improve HPV and cervical precancer treatment outcomes among HIV positive women in LMICs


NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Cerebrovascular;Neurosciences;Women's Health Research

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative   A  devastating  complication  of  many cancers,  brain  metastasis  is  initiated by a subset  of  circulating tumor  cells  (CTCs)  shed  into  systemic  circulation.  This  proposal  aims  to  dissect  the  mechanisms  of  a  transmembrane  receptor  in  mediating  the  CTCs  to  cross  the  blood  brain  barrier,  the  first  critical  step  for  establishing  brain  metastasis.  This  proposed  research  could  significantly advance our  understanding  of the  molecular  drivers  for  the first step of brain metastasis and facilitate the development of predictive markers and targeted therapies for  brain metastasis.

PI_NAMEs: YU, MIN  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Alanine;Binding;Biological Assay;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain tumor barrier;Brain;brain endothelial cell;Breast Cancer Cell;Breast Cancer Patient;cancer type;Cathepsins;CD100 antigen;cell motility;Cell Polarity;Cell Separation;Cells;Cephalic;Circulation;Co-Immunoprecipitations;Complex;Complication;connective tissue growth factor;CRISPR/Cas technology;Cytoplasm;Cytoplasmic Tail;Data;design;Development;Epithelium;In Vitro;in vivo;Incidence;Interruption;Knock-out;Knockout Mice;Knowledge;Ligands;Ligation;Link;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Membrane;Metastatic malignant neoplasm to brain;migration;Migration Assay;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;mutant;Mutate;Nature;Neoplasm Circulating Cells;neoplastic cell;overexpression;Pathway interactions;patient prognosis;Patients;PDZ protein;Peptides;Phosphorylation;predictive marker;prevent;protein complex;Proteins;Publishing;receptor;Regulation;Research;Resources;Role;Sampling;Serine;Signal Transduction;small hairpin RNA;Stream;Surface;synergism;Systemic Therapy;targeted treatment;Testing;Therapeutic;Tight Junctions;tumor

PROJECT_TITLE: Mechanisms of SEMA4D mediated breast cancer to brain metastasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-K(02)M]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Women's Health Research

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

PHR: PROJECT NARRATIVE The goal of this research project is to develop and test a next-generation system and method for soft tissue characterization using ultrasound images of breast cancer.

PI_NAMEs: HOYT, KENNETH  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Acoustics;Animal Model;Animals;Antineoplastic Agents;Apoptosis;Apoptotic;attenuation;Biological Process;Breast Cancer Model;Breast Cancer Treatment;breast imaging;Bypass;cancer cell;cancer therapy;Cell Aggregation;Cell Death;Cell Nucleus;Cell Size;Cell Survival;Cells;Characteristics;chemotherapy;Classification;Clinic;Clinical;clinical imaging;Clinical Research;Color;Custom;Data;deep learning algorithm;Dependence;design;Diffusion Magnetic Resonance Imaging;Discrimination;Disease Management;Dose;Drug resistance;Early Diagnosis;Early treatment;Environment;Exhibits;Frequencies;Goals;Health;Histologic;Hormones;human disease;human study;Image;imaging approach;imaging system;Imaging Techniques;Imaging technology;improved;In complete remission;in vivo;in vivo evaluation;Induction of Apoptosis;innovation;irradiation;Knowledge;Localized Malignant Neoplasm;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;Measurement;Measures;Methods;Modality;Monitor;Neoadjuvant Therapy;neoplastic cell;next generation;non-invasive imaging;Nuclear;Operative Surgical Procedures;Output;Pathologic;Pathology;Patients;Pattern;Pharmaceutical Preparations;Physiologic pulse;Play;pre-clinical;Pre-Clinical Model;prevent;Property;quantitative ultrasound;real-time images;Recurrence;Research;Research Project Grants;Resolution;response;Role;routine imaging;Scanning;Series;Signal Transduction;soft tissue;standard of care;Structure;success;System;targeted imaging;Techniques;Technology;Testing;theories;Therapeutic;Time;Tissue Sample;Tissues;Transducers;Transgenic Animals;transmission process;Treatment Failure;Treatment Protocols;treatment response;tumor;Ultrasonic Transducer;Ultrasonic wave;Ultrasonography;ultrasound

PROJECT_TITLE: Multifrequency ultrasound imaging for improved breast tissue characterization

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative UCLA Center for Health Improvement for Minority Elders (CHIME) proposes continuation of a research and mentoring program continuously funded in 2002, that will contribute to the reduction in health disparities for minority elders by training minority faculty who will advance their careers by conducting minority aging research.

PI_NAMEs: DURU, OBIDIUGWU KENRIK;MANGIONE, CAROL M (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Address;Aging;Area;Behavioral;beneficiary;Biological;California;care outcomes;career;Clinical Research;Collaborations;Communication;Communities;community based research;Community Developments;community engaged intervention;community engaged research;community intervention;County;Data Analyses;Data Set;design;Development;Economics;education research;Elderly;Elements;Evaluation;Faculty;Funding;Future;Geriatrics;Goals;Health;health disparity;health inequalities;Health Policy;Health Services Accessibility;Health Services Research;Health system;Healthcare;Hispanic;Hispanic-serving Institution;improve minority health;improved;Infrastructure;innovation;Internal Medicine;Intervention;Intervention Studies;Latinx;Lead;Leadership;Los Angeles;Measurement;Measures;Medicine;Mentors;Mentorship;Methodology;Minority;Minority Groups;minority health;minority health disparity;Minority Health Research;minority healthcare;minority investigator;older adult;Older Population;Outcome;Participant;Personal Satisfaction;Persons;Pilot Projects;Population;Productivity;programs;Recording of previous events;recruit;Reduce health disparities;Research;Research Design;Research Infrastructure;Research Institute;Science;Scientist;social;sociocultural determinant;Students;Teacher Professional Development;therapy design;tool;Training;Translational Research;Underrepresented Populations;Universities;Work

PROJECT_TITLE: The Center for Health Improvement of Minority Elderly