ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Harm Reduction for Substance Misuse;Pediatric;Prevention;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: To reduce harm related to high-risk alcohol use and negative consequences among young adults, researchers and preventionists have targeted normative misperceptions regarding the drinking behaviors of other young adults (i.e., norm-correcting interventions). The proposed project will develop and pilot test an innovative paradigm for leveraging social norms within brief interventions that entails user customization of which (and how many) normative referent groups they receive feedback for (e.g., drinking norms for sexual minoritized peers) so that the content is meaningful and engaging to all users, including historically marginalized groups. With proof-of-concept support that this novel intervention paradigm is feasible (i.e., acceptability, engagement, interest), efficacious relative to the standard PNF and attention-matched control conditions, and equitable for historically marginalized groups, this R34 project is anticipated to propel a line of research that could yield paradigm-enhancing discoveries pertaining to norms-based alcohol interventions.

PI_NAMEs: GRAUPENSPERGER, SCOTT ANTHONY (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: acceptability and feasibility;Age;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Attention;Attitude;Basic Science;Behavior;Birth;Brain;Brief Alcohol Screening and Intervention for College Students;brief intervention;college;demographics;design;Development;Distal;drinking;drinking behavior;Economics;efficacy evaluation;efficacy testing;Equity;Ethnic Origin;experience;feasibility testing;Feedback;follow-up;Frequencies;Goals;Greek;Habits;Harm Reduction;high intensity drinking;high risk;Hispanic;improved;indexing;Individual;innovation;interest;Intervention;Life Style;Literature;marginalization;marginalized population;minority student;National Institute on Alcohol Abuse and Alcoholism;Needles;normative feedback;novel;Online Systems;Participant;patient engagement;Pattern;peer;personalized normative feedback;Phase;Pilot Projects;pilot test;preference;Prevention;Process;product development;prototype;public health priorities;Race;Reporting;Research;Research Personnel;Sampling;satisfaction;Seminal;sex;Sexual and Gender Minorities;sexual minority;Social Identification;social norm;statistics;Students;Surveys;Target Populations;Technology;Testing;theories;therapy development;treatment as usual;Universities;user centered design;web-based intervention;young adult

PROJECT_TITLE: A user-customizable personalized normative feedback intervention for alcohol harm reduction in young adults: Feasibility, acceptability, and preliminary efficacy.

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Pediatric;Prevention

ORG_CITY: CLEVELAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_FIPS: US

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Non-alcoholic fatty liver disease and its more severe form, non-alcoholic steatohepatitis are now termed metabolic dysfunction-associated steatotic liver disease/steatohepatitis to focus on the underlying causal mechanisms. In this term-limited renewal, we will complete the ongoing prospective cohort studies (database) in children and adults (to define the natural course of NAFLD), and the vitamin E dosing study (VEDS) to identify the lowest effective therapeutic dose of vitamin E for NASH. Additionally, we will utilize existing multimodal data repositories to identify novel biomarkers and therapeutic targets for severity of NAFLD and sarcopenia using integrated multiomics analyses of clinical, genetic, transcriptomic, proteomic, histological, and imaging data.

PI_NAMEs: DASARATHY, SRINIVASAN  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Address;Adherence;Adult;Alcohol consumption;Alcoholic Liver Diseases;Alcohols;Ammonia;Archives;biobank;Bioinformatics;Biological Markers;Caloric Restriction;Cardiovascular system;Characteristics;Child;Childhood;Cirrhosis;Clinical;clinical care;clinical center;Clinical Data;Clinical Research;clinical research site;Clinical Trials;cohort;Data;Data Analyses;Data Analytics;Data Coordinating Center;data repository;Data Set;Databases;Development;Diagnosis;diagnostic biomarker;diagnostic criteria;dietary;Disease;Disease Progression;Dose;Drug Kinetics;effective therapy;Enrollment;Ensure;Ethanol Metabolism;Event;exercise training;experience;Fibrosis;Foundations;Funding;Funding Opportunities;Future;Genes;Genetic;Genomics;Goals;Hepatic;Histologic;Histology;Hyperammonemia;Image;Impairment;improved;insight;Institutional Review Boards;Licensing;Life Style;Life Style Modification;lipidomics;Liver;liver biopsy;Liver diseases;liver injury;Magnetic Resonance Imaging;Manuscripts;Masks;Mediator;Metabolic;Metabolic dysfunction;Metabolism;metabolomics;multimodal data;Multiomic Data;multiple datasets;multiple omics;Muscle;Muscular Atrophy;new therapeutic target;NIH Program Announcements;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;noninvasive diagnosis;Notification;novel;novel diagnostics;novel marker;novel therapeutics;Outcome;Outcome Measure;Participant;participant enrollment;Pathogenesis;Pathway interactions;patient oriented;Patients;Pediatric Hospitals;pediatric patients;Phase Transition;Physical activity;potential biomarker;Process;Productivity;Prognostic Marker;programs;prospective;Prospective, cohort study;Proteomics;Protocols documentation;Public Health;Publications;Publishing;Radiology Specialty;Randomized;randomized, clinical trials;Recommendation;Records;recruit;repository;Research;Risk;sarcopenia;Severities;Severity of illness;simple steatosis;Site;Societies;Staging;Standardization;Steatohepatitis;Terminology;Testing;Therapeutic;Therapeutic Clinical Trial;therapeutically effective;Time;transcriptome sequencing;transcriptomics;treatment arm;Visit;Vitamin E

PROJECT_TITLE: Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Clinical Center-Cleveland site

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-6 (M2)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Racial and Ethnic Minority Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: The findings reported in Genome-Wide Association Studies (GWAS) are increasingly used to develop Polygenic Scores (PGS) to predict phenotypes and disease risk. Non-Europeans are severely underrepresented in GWAS data, and European-derived PGS have poor predictive performance when used to predict phenotypes of individuals of non-European ancestry. In this project, we will develop novel Transfer Learning algorithms to develop PGS for ancestries underrepresented in GWAS data that will leverage the large sample size available for Europeans and the diversity of the recently developed All of Us program.

PI_NAMEs: DE LOS CAMPOS, GUSTAVO  (contact)

PROGRAM_OFFICER_NAME: KULCHAK RAHM, ALANNA LEE

PROJECT_TERMS: African American population;Algorithms;All of Us Research Program;American;Analysis of Variance;Bayesian Method;Bayesian Modeling;Benchmarking;biobank;Catalogs;Chromosomes;cohort;Complex;Computer software;Data;Data Set;Development;disorder risk;Elasticity;European;Exhibits;experience;flexibility;Gene Frequency;Genome;genome wide association study;Genomic Segment;Genomics;Goals;Heritability;Hispanic Populations;improved;Individual;Industry;Knowledge;Lasso;Latino Population;Learning;learning algorithm;learning strategy;Linkage Disequilibrium;Maps;Methods;Modeling;novel;open source;Performance;Phenotype;Population;portability;Publishing;Reporting;Research;Resources;Sample Size;Scientist;sex;SNP genotyping;Techniques;training opportunity;trait;transfer learning;Underrepresented Populations;Variant

PROJECT_TITLE: Improving PGS Prediction for Underrepresented Groups Through Transfer Learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-P (M1)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Patient Safety;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: DANVILLE

ORG_NAME: GEISINGER CLINIC

ORG_STATE: PA

PHR: NARRATIVE Genomic medicine has long been recognized as having the potential to improve population health, but it has not become routine, equitably distributed healthcare. Rigorous evaluations of how genomic medicine interventions are implemented across diverse healthcare settings are necessary to realize the population health potential of genomic medicine. We propose to contribute our expertise in genomic medicine, implementation science and learning health systems as a Clinical Site in the Network of Genomics-Enabled Learning Health Systems, advancing the goal of improving population health by making genomic medicine routine across all healthcare settings.

PI_NAMEs: BUCHANAN, ADAM H (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Address;Age;biobank;cancer risk;Caring;Characteristics;clinical care;Clinical Data;clinical decision support;clinical implementation;clinical research site;clinically actionable;Collaborations;Communities;Community Health Systems;Community Healthcare;community partners;Consent;contextual factors;Data Collection;data infrastructure;data modeling;Data Science;design;Disease;disorder risk;Documentation;Electronic Health Record;Elements;Equity;Evaluation;evidence base;experience;genomic data;Genomic medicine;Genomics;Goals;Grant;health care settings;health communication;Health system;Healthcare;Healthcare Systems;Hereditary Malignant Neoplasm;implementation barriers;implementation facilitation;implementation framework;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Individual;innovation;Institution;Intervention;Interview;Learning;life span;Maps;medical specialties;Medicine;Methods;Modeling;National Human Genome Research Institute;Outcome;Participant;patient population;Patient Representative;Patients;Pharmaceutical Preparations;Pharmacogenomics;Pharmacotherapy;Phase;point of care;population health;portability;Primary Care;Research;Research Personnel;Resources;Risk;Rural;rural healthcare;Rural Population;Science;Scientist;screening;screening program;socioeconomics;Standardization;Strategic vision;Structure;structured data;success;sustainability framework;System;targeted treatment;Testing;Underrepresented Populations;underserved community;Variant;Work

PROJECT_TITLE: Making Genomic Medicine Routine in a Rural Healthcare System

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (M1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Disease;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative Metabolic dysfunction-associated steatotic liver disease (MASLD) affects one in three adults in North America and rates of liver-, cardiovascular-, and cancer- related complications on the rise. The NASH CRN has made landmark contributions to the field, but knowledge gaps remain. In this funding cycle, the CRN will complete longitudinal follow-up of adult and pediatric participants and the vitamin E dosing finding study and leverage the available clinical, histologic, radiologic, social, contextual, genetic, proteomic, and metabolomic data to better understand disease progression, improve diagnostic and prognostic precision and ultimately, improve the outcomes of persons with MASLD.

PI_NAMEs: TERRAULT, NORAH A. (contact)

PROJECT_TERMS: Address;Adult;adverse outcome;Affect;Ancillary Study;biobank;Biological Markers;biological specimen archives;Cardiovascular system;Categories;Censuses;Child;Childhood;Cirrhosis;Clinical;clinical care;clinical center;clinical practice;clinical predictors;Clinical Research;clinical trial participant;Clinical Trials;cohort;Complementary DNA;cost;Coupled;cytokine;Data;Databases;deprivation;Development;diabetogenic;Diagnostic;Disease;disease diagnosis;Disease Outcome;Disease Progression;DNA;Dose;Enrollment;Environment;Evaluation;Fibrosis;follow-up;food desert;food insecurity;Funding;Future;Genetic;genetic variant;genome wide association study;Germ Lines;Green space;Health;health determinants;health disparity;Health Services Accessibility;Hepatic;Histologic;Household;Image;improved;improved outcome;Incidence;indexing;Individual;insight;Knowledge;Laboratories;Link;Liver;Liver diseases;liver transplantation;Longitudinal cohort;longitudinal database;Longitudinal, observational study;Losartan;Low income;Malignant neoplasm of liver;Malignant Neoplasms;Measurement;Measures;Metabolic dysfunction;metabolic phenotype;metabolic-associated fatty liver disease;metabolomics;Modeling;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Neighborhoods;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;North America;novel therapeutics;Outcome;Participant;Pathogenesis;Pathologic;Patients;pediatric non-alcoholic fatty liver disease;Persons;Phase;Phenotype;Plasma;Population;Prevalence;Prognosis;prognostic;Proteomics;public-private partnership;Radiology Specialty;Recommendation;repository;Research Personnel;Risk;risk prediction model;risk stratification;Sampling;Serum;Severity of illness;simple steatosis;Site;social;Social Conditions;social deprivation;social determinants;social health determinants;socioeconomics;Steatohepatitis;structural determinants;structural health determinants;Surveys;Tissues;Translational Research;translational study;Visit;Vitamin E;Work

PROJECT_TITLE: Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)


ADMINISTERING_IC: ES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative Climate change is a fundamental threat to human health and well-being. While its effects are already being felt, the effects of climate change are expected to intensify over the coming decades. The overall goal of this exploratory grant is to develop a climate change and health research center to explore the dynamics between health and climate change-driven exposures to heat, pathogenic microbes, and environmental toxicants, and to develop novel interventions that promote resiliency in vulnerable populations.

PI_NAMEs: LEIKAUF, GEORGE DOUGLAS;MORROW, ARDYTHE L (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Address;Architecture;Area;Attention;Award;biobank;Bioinformatics;Biology;Biometry;career;career development;certificate program;Cities;Climate;climate change;climate forcing;climate impact;climate-related health;Clinical;Collaborations;Communicable Diseases;Communities;community academic partnership;community collaboration;community engagement;Community Health;Community of Practice;community organizations;community partners;community partnership;Data;design;Development;Ecology;Educational Grants;Educational Materials;Educational process of instructing;effective intervention;Elements;Environmental Engineering technology;Epidemiology;ergonomics;Event;experience;exposure pathway;Exposure to;extreme heat;extreme weather;Faculty;first responder;Floods;Frequencies;Funding;Goals;Grant;Health;health communication;health equity;Health equity research;Heat Stress;Heat Stress Disorders;Heat Waves;Home;Human;Hypersensitivity;Immune;immune health;Immunology;improved;Individual;innovation;Institution;Internal Medicine;Intervention;Intervention Studies;Investigation;Low income;Lung;marginalized community;Mentors;microbial;microbiome;Midwestern United States;Monitor;Mucosal Immunity;Mucous Membrane;Newsletter;novel;Ohio;Outcome;Outcomes Research;Participant;pathogen;pathogenic microbe;Pediatrics;Personal Satisfaction;Phase;Pilot Projects;Precipitation;Prevention;Process;programs;promote resilience;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;resilience;Resources;Risk;Role;Sampling;Science;Scientist;screening;Series;Temperature;Testing;thermal stress;Toxic Environmental Substances;toxicant;Toxicant exposure;Toxicology;Training;transcriptome;Translations;trend;United States National Institutes of Health;Universities;urban area;vulnerable community;Vulnerable Populations

PROJECT_TITLE: Cincinnati Climate Change and Health Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-K (C2)]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MORROW, ARDYTHE L (contact)

PROJECT_TERMS: Accountability;Address;Attention;Award;Budgets;climate change;climate-related health;Collaborations;Communication;Communities;Community of Practice;community partners;data management;data sharing networks;Databases;Development;Elements;Ensure;Environment;Evaluation;Expenditure;Exposure to;first responder;Fostering;Funding;Funding Agency;Goals;Grant;Growth;Health;health equity;individual variation;Infrastructure;innovation;Institution;interdisciplinary collaboration;Intervention;Intervention Studies;Lead;Leadership;Low income;meetings;member;Monitor;novel;pathogen;Pilot Projects;Play;Productivity;promote resilience;Public Health;Publications;recruit;Research;resilience;Resource Development;Resources;Risk;Role;Science;Series;Structure;success;Toxic Environmental Substances;Training;Translational Research;United States National Institutes of Health;Vulnerable Populations;Work;Workforce Development

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Social Determinants of Health

PI_NAMEs: LEIKAUF, GEORGE DOUGLAS (contact)

PROJECT_TERMS: Address;adverse outcome;Affect;Age;Air Conditioning;Area;biobank;Bioinformatics;biomarker identification;Biometry;Body Temperature;Cellular Phone;Characteristics;Cities;Classification;Climate;climate change;climate-related health;Communities;Data;Data Reporting;Development;Drowsiness;Elderly;Event;Exposure to;extreme heat;extreme temperature;Fatigue;fire fighter;Gait;Health;Heart Rate;heart rate variability;heat island;Heat Stress;Heat Stress Disorders;Heat Waves;Home;Housing;Humidity;Hyperthermia;Immune;Individual;Individual Differences;Intervention;marginalized population;Measures;member;Midwestern United States;Monitor;Mucous Membrane;Musculoskeletal Equilibrium;nasal swab;Neighborhoods;Neurologic;Neurological outcome;Nose;Outcome;Patient Self-Report;personalized approach;Physiological;Populations at Risk;Predisposition;Public Health;Questionnaires;Race;Readiness;Recovery;recruit;Research;Research Project Grants;residence;Resources;responders and non-responders;response;Risk;Risk Management;sensor;Severities;Severity of illness;Sleep;smart watch;social cohesion;social health determinants;Socioeconomic Status;Specimen;Surveys;Symptoms;Temperature;Testing;Time;Training;transcriptome;transcriptome sequencing;transcriptomics;Trees;Variant;Vulnerable Populations;wearable sensor technology;Whole Blood

PROJECT_TITLE: Research Project-1


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Social Determinants of Health

PI_NAMEs: BURBAGE, MICHELLE L. (contact)

PROJECT_TERMS: Address;Affect;Award;career;Climate;climate change;climate crisis;climate impact;climate-related health;Collaborations;Communication;Communities;community academic partnership;community advisory board;community collaboration;community consultation;community engagement;community organizations;community partners;cultural competence;Dedications;Development;Disparity;Education;Educational Materials;Eligibility Determination;Ensure;Environment;environmental justice;Equity;experience;Feedback;Fortification;Goals;Grant;Health;Heart;improved;Infrastructure;innovation;insight;Institution;interest;Intervention;Knowledge;Link;marginalized community;member;Nonprofit Organizations;Ohio;Outcome;Output;outreach;Pathway interactions;Perception;Pilot Projects;Policies;Population;programs;Public Health;Recording of previous events;recruit;Relaxation;Research;Research Personnel;Research Project Grants;resilience;Resources;Science;Strategic Planning;Structure;student training;Students;success;synergism;Training;Universities;Voice;Work

PROJECT_TITLE: Community Engagement Core


PI_NAMEs: BRUNST, KELLY J (contact)

PROJECT_TERMS: Acceleration;Address;Advocate;Air;Architecture;Award;Basic Science;Behavioral Research;Benchmarking;Cancer Center Planning Grant;career;career development;Certification;Climate;climate change;climate-related health;Clinical Research;Collaborations;college;Communication;community partnership;community planning;community research;Conscious;Dedications;design;Development;Diverse Workforce;early-career faculty;Ecosystem;Education;Educational Curriculum;empowerment;Ensure;Environmental Health;Epidemiology;Exposure to;Faculty;Fostering;Funding;Funding Mechanisms;Future;Goals;graduate student;Grant;Health;health equity;Health Professional;Health Services;Housing;innovation;interdisciplinary collaboration;Interdisciplinary Study;Internships;Intervention;Investments;Justice;Learning;Medicine;Mentors;Mentorship;Methodology;Mission;next generation;novel;Outcome;pathogen;Pilot Projects;Play;Population Research;Productivity;programs;Public Health;recruit;Research;Research Personnel;resilience;Role;Scholars Program;Scientist;Shapes;skills;Social Work;Societies;Sociology;Structure;Students;Talents;teacher community;Time;Toxic Environmental Substances;Training;Transcend;Transportation;undergraduate student;Underrepresented Minority;Universities;Update;urban planning;Vulnerable Populations;Wages;Work;Workforce Development

PROJECT_TITLE: Development Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Congenital Structural Anomalies;Heart Disease;Kidney Disease;Neurosciences;Pediatric;Polycystic Kidney Disease

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: The importance of mechanosensitive channels to human health is underscored by the association of many disease states with compromised mechanosensation, including atrial fibrillation, muscular degeneration, arrhythmias, polycystic kidney disease, and numerous neural diseases. Therefore, it is the goal of this work is to understand both generalizable and cell type specific roles of mechanosensation in regulating gene expression, cellular motility, and cell-to-cell communication.

PI_NAMEs: STRATMAN, AMBER NICOLE (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: 3-Dimensional;Affect;Arrhythmia;Astrocytes;Atrial Fibrillation;Biological;Biological Assay;blood pressure regulation;Cell Communication;cell motility;cell type;Cells;Communication;Communities;Complex;Data;Disease;Endothelial Cells;Environment;Equilibrium;Gene Expression;Goals;Health;Human;In Vitro;Individual;intercellular communication;interest;Ions;Knowledge;Morphogenesis;Movement;Muscle;neural;Normal tissue morphology;Osmosis;parent grant;Pattern;Play;Polycystic Kidney Diseases;programs;Proteins;Regulation;Research;Role;Second Messenger Systems;Signal Transduction;Smooth Muscle Myocytes;Stretching;Tissue Model;Tissues;Touch sensation;Transcriptional Activation;Work;zebrafish development

PROJECT_TITLE: Mechanosensitive mechanisms regulating cellular coordination during tissue morphogenesis and patterning


ORG_CITY: GRAND FORKS

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PHR: TRANSCEND-Overall  Overall Narrative The TRANSCEND CTR is a center for training and research in clinical and translational research (applied research to prevent or treat disease) in North Dakota. TRANSCEND is an acronym for Translational Science Engaging North Dakota. It employs innovative programs that combine clinicians, basic biomedical researchers, and infrastructure in North Dakota universities and hospitals to do impactful research on diseases that disproportionately affect people in North Dakota. TRANSCEND is an academic/clinical/community partnership in which different communities, including minority communities, are involved directly in the planning, performing, and utilization of research findings. Its overall goal is to increase the size of the research workforce whose skills can improve the health of people in North Dakota and the region.

PI_NAMEs: SCHWARTZ, GARY G (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: acronyms;Affect;African American;Age Years;Alzheimer's Disease;American;Applied Research;Area;Asian;Basic Science;bench to bedside;binge drinking;Caring;Censuses;Chronic;Chronic Disease;Clinic;Clinical;clinical center;Clinical Research;Clinical Skills;clinical training;Collaborations;Colorectal Cancer;Communities;community clinic;community engagement;Community Health;community intervention;Community Outreach;community partnership;Community Physician;Data;Data Analyses;Demography;density;Department chair;Development;Disease;Education;Engineering;Enrollment;Environmental Exposure;Epidemiology;Evolution;experience;Extramural Activities;Faculty;financial incentive;Funding;Future;Goals;Grant;Health;Health Sciences;Healthcare;High Prevalence;Hospitals;Improve Access;improved;Indigenous;Infrastructure;innovation;Institution;interest;Intervention Studies;investigator training;Investments;life span;Lung Diseases;Malignant neoplasm of lung;Malignant Neoplasms;medical schools;meetings;Mentors;Mentorship;Methods;metropolitan;minority communities;Modeling;Names;Native Americans;Neurodegenerative Disorders;North Dakota;outreach;Parkinson Disease;Patients;Persons;Physicians;Pilot Projects;podcast;Poverty;Preparation;prevent;Problem behavior;Process;Program Development;programs;Public Health;Publications;Race;Radon;Research;research and development;Research Design;Research Infrastructure;Research Personnel;Research Training;Rural;Schools;Science;Scientist;skills;skills training;Step training;Stroke;Structure;Students;Suicide;suicide rate;Training;Training Programs;Transcend;Translational Research;tribal college;Universities;Vision;Youth

PROJECT_TITLE: Translational Science Engaging North Dakota (TRANSCEND)

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (CD)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Rural Health

PROJECT_TERMS: Address;Advisory Committees;Clinical;Colorectal Cancer;Communities;Community Physician;continuing medical education;Data;design;Education;effectiveness evaluation;Environment;Ethics;experience;Faculty;Fostering;functional improvement;Goals;Grant;Health;High Prevalence;Incentives;innovation;Institution;interest;Knowledge;Leadership;Measures;Methods;Neurodegenerative Disorders;North Dakota;operation;Principal Investigator;Productivity;Radon;Research;Research Personnel;Rural Hospitals;skills;Structure;success;Suicide;Transcend;translational goal;Translational Research;Work


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: LINDSETH, GLENDA N (contact)

PROJECT_TERMS: addiction;Address;Affect;American Indians;Area;Attention;Awareness;Behavior Disorders;Behavior Therapy;Behavioral;Child;Clinical Research;Communication;Communities;community advisory board;community based participatory research;community based research;community clinic;community engaged research;community engagement;Community Health;Community Outreach;Community Participation;culturally appropriate intervention;Dementia;design;Development;Diabetes Mellitus;disabled;Disease;Disparity population;effective intervention;Effectiveness;Elderly;Electronic cigarette;Extramural Activities;Faculty;Family;Farm;Goals;Growth;Health;Health Benefit;health disparity;Health Priorities;Health Status;Healthcare;improved;Individual;Interdisciplinary Study;Intervention;Leadership;Link;Malignant Neoplasms;marginalized population;Mediating;Mental Depression;Minority Groups;Mission;North Dakota;Outcome;Participant;Pathology;Patient Care;patient oriented;Physiological;Pilot Projects;Policies;Policy Developments;Population;Prevention;Program Development;programs;Radon;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Role;Rural;rural families;Scientist;Societies;success;Suicide;Testing;Time;Tobacco;Translating;Translational Research;Translations;tribal leader;Tribes;Underserved Population;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Community Engagement & Outreach Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Networking and Information Technology R&D (NITRD)

PI_NAMEs: HUR, JUNGUK  (contact)

PROJECT_TERMS: Area;Artificial Intelligence;Bioinformatics;Biometry;Clinical;Clinical Data;clinical infrastructure;Clinical Management;Clinical Research;Collaborations;community engagement;Community Outreach;Consultations;data management;Data Set;Databases;design;Development;Discipline;Economic Development;Education;Epidemiology;Event;experience;Experimental Designs;Feedback;Future;Goals;Health;High Performance Computing;Infrastructure;Knowledge;Lead;member;Mentors;Methodology;North Dakota;operation;Participant;power analysis;Procedures;Process;Regulation;Research;research and development;Research Design;Research Methodology;Research Personnel;Research Training;Resources;Rural;Services;Shapes;skills;Speed;Statistical Methods;statistics;Talents;Training;translational engagement;Translational Research;Validation;virtual;virtual reality

PROJECT_TITLE: Research Design, Compliance & Data Management Core


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

ORG_STATE: WA

PHR: Project Narrative Opioid use disorder is the consequence of altered neural circuit function and is an epidemic that causes an extraordinary amount of death and human suffering. This proposal seeks to determine the activity dynamics and causal function of subpopulations of lateral hypothalamic area neurons throughout the development and expression of motivation for opioids. At the conclusion of this proposal, we will gain deeper insight into the spatiotemporal dynamics during motivation for opioids that will inform future research into targeted therapeutics for treating opioid use disorder.

PI_NAMEs: GORDON-FENNELL, ADAM G (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Animals;Attenuated;Behavior;Behavioral;behavioral phenotyping;behavioral study;Brain;calcium indicator;Cells;Cessation of life;Communities;Corpus striatum structure;Data;designer receptors exclusively activated by designer drugs;Development;Dopamine;dopamine system;drug of abuse;drug reward;Electric Stimulation;Epidemic;experimental study;Fiber;Food;Foundations;gamma-Aminobutyric Acid;Glutamates;Heroin;Human;Hypothalamic structure;Image;Individual;Ingestion;insight;Intervention;Intravenous;Investigation;Lateral;Lateral Hypothalamic Area;Lesion;Maps;Mediating;Midbrain structure;Modification;Monitor;mortality risk;Motivation;Mus;neural circuit;neural patterning;neuronal circuitry;Neurons;neurotransmission;Neurotransmitters;non-drug;Nucleus Accumbens;Opioid;opioid injection;Opioid Peptide;Opioid Receptor;opioid use;opioid use disorder;opioid withdrawal;Pharmaceutical Preparations;Pharmacology;Photometry;Play;Population;preventable death;recruit;Regulation;reinforced behavior;Research;Research Personnel;response;Rewards;Role;Schedule;Self Administration;Shapes;Signal Transduction;Site;spatiotemporal;stem;Structure;Substance Use Disorder;Sucrose;System;targeted treatment;Techniques;Testing;theories;Training;two-photon;United States;Ventral Tegmental Area;Work

PROJECT_TITLE: Investigation into the function of hypothalamic GABA and glutamate in motivation for opioid reward

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 MXS-T (M1)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Disease;Pediatric;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: The Children’s Hospital of Philadelphia proposes to continue our participation in the ChiLDReN consortium, a group of pediatric centers working together to study rare pediatric liver diseases. These diseases are important causes of suffering and death in children, but they are so rare that only by collaborating can we hope to improve outcomes for these children. The ChiLDReN study protocols involve collection of longitudinal data and biospecimens that can be leveraged for new discoveries of biomarkers and genetic etiology of disease.

PI_NAMEs: KAMATH, BINITA MAYA;LOOMES, KATHLEEN MARY (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Acceleration;Agreement;Ancillary Study;Area;Biliary Atresia;biobank;Biological;Biological Markers;Biological Specimen Banks;biomarker discovery;Caring;Cessation of life;Child;Childhood;Cholestasis;clinical database;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Collection;Committee Membership;Data;Data Collection;data exchange;data quality;Databases;Development;Diagnosis;Disease;Elements;Enrollment;Ensure;Genetic;Genetic Predisposition to Disease;Genomics;Hospitals;Human Resources;improved;improved outcome;Individual;Infrastructure;Institution;interest;Intervention Studies;Investigation;Knowledge;Laboratories;Lead;Leadership;Liver diseases;Logic;Manuscripts;member;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Observational Study;optimal treatments;Outcome;Participant;participant retention;participant safety;Pathogenesis;patient population;Patient Recruitments;Patients;Pediatric Hospitals;Performance;Philadelphia;Physicians;Principal Investigator;Procedures;Productivity;programs;Protocols documentation;Quality Control;Quality of Care;Rare Diseases;repository;Request for Applications;Research;Research Institute;Research Personnel;research study;response;Role;Sampling;Scientific Advances and Accomplishments;Scientist;Secure;Site;Structure;success;translational study;treatment strategy;working group;Writing

PROJECT_TITLE: Advancing our Understanding of Rare Pediatric Liver Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-Q (M1)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: Narrative Clonal hematopoeisis (CH) is a premalignant condition that is strongly associated with aging, inflammation, cardiovascular disease and mortality from all causes. The three proteins most frequently mutated in CH are TET2, DNMT3A and ASXL1. We will test the hypothesis that mutations in all three proteins are linked to reduced levels of two epigenetic marks, DNA and H3K9 methylation. We will also test the hypothesis that a fourth protein, OGT, links TET2 and ASXL1. Our studies will illuminate the mechanistically elusive connections between DNA and H3K9 methylation, cancer, inflammation and aging, and will improve our understanding of heterochromatin, a compartment of the genome that is very poorly understood.

PI_NAMEs: RAO, ANJANA  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Aging;Biochemical;Cardiovascular Diseases;Cell Lineage;Cells;Complex;CRISPR screen;demethylation;DNA;DNA Methylation;DNA Transposable Elements;DNMT3a;Enhancers;Epigenetic Process;Family;Funding;Genes;Genome;genome-wide;Genomic Instability;Genomics;Hematopoiesis;Hematopoietic;Heterochromatin;Histones;Impairment;improved;Individual;Inflammation;Knockout Mice;Lead;Link;link protein;Lysine;Malignant Neoplasms;member;Methylation;mortality;Mus;mutant;Mutate;Mutation;Precancerous Conditions;Process;promoter;protein complex;protein protein interaction;Proteins;restraint;Severity of illness;Testing

PROJECT_TITLE: The TET-DNMT-ASXL1-OGT axis: relevance to clonal hematopoiesis, heterochromatin integrity and cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-E (M1)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: SOUTH BEND

ORG_NAME: MEANINGFUL MEASUREMENT, INC.

ORG_STATE: IN

PHR: Project Narrative This R41 proposes to develop a prototype mobile health (mHealth) app, R-Assist, by a cross-disciplinary small business and academic team. R-Assist will be the first mHealth product designed specifically for individuals with co-occurring opioid use and mental health disorders (COD) during the vulnerable time of leaving jail and transitioning to the community to provide on-demand, 24/7 support to improve COD symptoms and recovery, and address social determinant of health needs. App feature development will be guided by the self- determination theory, and it will undergo initial field testing using an agile iterative design followed by an open pilot with clients.

PI_NAMEs: SMELSON, DAVID A;TATUM, DONNA  (contact)

PROGRAM_OFFICER_NAME: FLOOD, MORRIS

PROJECT_TERMS: Accounting;addiction;Address;Agreement;Android;Area;Artificial Intelligence;authority;Behavior;behavioral health;Businesses;care coordination;Caring;chatbot;Client;Clinical;Cognitive;cohort;Cohort Studies;Collaborations;commercialization;Communities;computer science;Computer software;cost;County;Criminal Justice;dashboard;design;Development;digital;digital health;Economics;Educational Curriculum;empowerment;Evaluation;evidence base;experience;feasibility testing;Feedback;field study;Focus Groups;formative assessment;Goals;Health Food;Health Resources;Health Services;Health Services Accessibility;Health Technology;Healthcare;high risk;Homelessness;Housing;improved;Individual;Internet;Intervention;iterative design;Jail;Justice;Lead;Letters;Libraries;Licensure;Link;Lived experience;Massachusetts;Measurement;Medicaid;Medication Management;Mental disorders;Mental Health;mHealth;Mobile Health Application;Modification;Monitor;National Institute of Drug Abuse;next generation;opioid use;outreach;Overdose;overdose risk;Patient Self-Report;Pharmaceutical Preparations;Phase;phase II trial;Pilot Projects;poor communities;population health;Population Sciences;Preparation;Process;prototype;Psychiatry;Public Health;randomized trial;Recovery;Rehabilitation therapy;reincarceration;Relapse;Research Personnel;Resources;Risk;Rural;Rural Community;Safety;Security;Self Assessment;Self Determination;self help;Services;Small Business Technology Transfer Research;sobriety;social health determinants;Social Work;software development;substance use;symptom management;Symptoms;System;Systems Integration;Tablets;Taxes;Technology;Testing;theories;Thinking;Time;tool;Tribes;Universities;usability;virtual;Walking;Woman;Work

PROJECT_TITLE: Reentry-Assist App Development for Individuals with Addiction and Mental Illness

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 CEM-S (M1)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Data Science;Genetics;Human Genome;Microbiome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: NOTRE DAME OF MARYLAND UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative We propose to create two short format, introductory, modular, Course-based Undergraduate Research Experiences (miniCUREs) based on computational genomics and data science (CGDS) content (RNA-seq and the human microbiome) using the NIH cloud computing platform AnVIL. The AnVIL-based miniCUREs will be piloted at 5 institutions, including two Hispanic Serving Institutions and one Tribal College prior to public release, to allow for evaluation and revision. The miniCUREs can then be used by everyone from 2 year colleges to Master’s programs to improve student’s knowledge and experience in research of CGDS topics.

PI_NAMEs: ALCAZAR, ROSA MARIA;KERR, JENNIFER EVANGELINE (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Address;Adoption;Bioinformatics;Biology;California;catalyst;Cloud Computing;Cloud Service;Collaborations;college;community college;computational platform;Computer software;Data;data access;data integration;Data Science;Data Set;Development;Diné Nation;diverse data;Education;Educational Curriculum;Educational process of instructing;Ensure;Equipment;Equity;Evaluation;experience;Faculty;Funding Opportunities;genome sciences;genomic data;Genomics;gut microbiome;hands on research;Health;Hispanic-serving Institution;Human;human data;Human Microbiome;Hybrids;improved;Informatics;innovation;Institution;instructor;Knowledge;lectures;Maryland;massive open online courses;materials science;Metagenomics;Methods;microbial;Minority;Minority-Serving Institution;Mission;Modernization;National Human Genome Research Institute;next generation;North Carolina;open source;pedagogy;Persons;Positioning Attribute;posters;programs;Research;Research Personnel;Resources;Sampling;scaffold;skills;student retention;student training;Students;success;symposium;Teacher Professional Development;Technology;Time;tool;Training;transcriptome sequencing;tribal college;undergraduate research experience;undergraduate student;Underrepresented Students;underserved students;United States National Institutes of Health;Universities;Visualization

PROJECT_TITLE: Modernizing biology curricula by developing accessible genomic data science miniCUREs for the AnVIL platform

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-M (M1)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROLOGY

PHR: Microglia, the innate immune cells of the brain, contribute to Alzheimer Disease (AD). We aim to identify microglia functions contributing to AD using novel Artificial Intelligence applications and identify targets that can be leveraged for therapeutic design.

PI_NAMEs: JAYADEV, SUMAN  (contact);LEE, SU-IN

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Address;Age;age related;Aging;aging related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapeutic;Amyloid;Amyloid beta-Protein;Artificial Intelligence;ATAC-seq;Autophagocytosis;Autopsy;Biological Assay;Biology;Brain;brain cell;brain tissue;Cell Culture Techniques;Cell Nucleus;cell type;Cells;Chemotaxis;Chromatin;Clinical;Coculture Techniques;computer studies;cytokine;Data;Data Set;deep learning;design;Disease;Disease Progression;economic cost;empowerment;Experimental Models;explainable artificial intelligence;Explosion;Exposure to;Functional disorder;Gene Expression Regulation;gene network;gene regulatory network;Genetic;Genetic study;Genetic Transcription;Heterogeneity;Human;human induced pluripotent stem cells;Immune;Immune Targeting;improved;In Vitro;Incidence;Individual;induced pluripotent stem cell;Inflammaging;Inflammation;Inflammatory;innovation;insight;Interleukins;Intervention;Mediating;Mediator;Methods;Microglia;Modeling;Molecular;Motility;multiple omics;neuron loss;Neuronal Injury;Neurons;novel;novel therapeutics;Pathogenesis;Pathologic;Pathologic Processes;Pathology;Pathway Analysis;Pathway interactions;Patients;Phenotype;Process;Proteins;Regulation;Reporting;response;RNA;Role;Sampling;single nucleus RNA-sequencing;single-cell RNA sequencing;social;stem cell model;Stimulus;stressor;Synapses;tau Proteins;Techniques;Testing;Therapeutic;transcriptome sequencing;transcriptomics;ultraviolet irradiation

PROJECT_TITLE: Illuminating early microglial dysfunction in Alzheimer's disease through integration of explainable AI and iPSC models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Complementary and Integrative Health;Drug Abuse (NIDA only);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: Boulder

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE: Our goal is to better understand the emergence of adolescent substance use behaviors by testing the hypothesis that music engagement is associated with less substance use initiation and less frequent substance use. There is already evidence that music engagement interventions are effective for individuals with substance use disorders, and there are multiple reasons to expect these beneficial effects could extend to substance initiation in adolescence. By integrating state-of-the art genetic and longitudinal approaches that address key confounds, this work will quantify these potentially protective associations and provide critical groundwork for translational and intervention efforts targeted at supporting high-risk individuals before the onset of problematic substance use.

PI_NAMEs: GUSTAVSON, DANIEL  (contact)

PROGRAM_OFFICER_NAME: VIDAL, SARAH

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent substance use;Adoption;Affect;Age;Alcohols;American;Award;Behavior;behavior test;Behavioral;Biological;biological sex;Biometry;Brain;Child;Cognitive aging;cognitive development;Colorado;Competence;Data;Data Analyses;Data Set;Development;Disease susceptibility;Early identification;effective intervention;Emotional;Environment;Environmental Risk Factor;Equation;Etiology;experimental study;Family;Family Study;gene environment interaction;Genetic;genetic analysis;Genetic Risk;Genomic approach;genomic data;Genomics;Genotype;Goals;Health;Heterogeneity;high risk;high risk population;illicit drug use;improved;Individual;Individual Differences;instrument;Intercept;Intervention;Intervention Studies;large datasets;life span;Link;Literature;longitudinal analysis;Measures;Mendelian randomization;Methods;Mission;Modeling;Music;Music Therapy;National Institute of Drug Abuse;Nature;peer;Personal Satisfaction;Pharmaceutical Preparations;Phenotype;Play;Policies;Predisposition;prevent;Prevention;preventive intervention;programs;prospective;protective factors;Quality of life;reduced substance use;Research Support;Risk;Risk Factors;Risk Marker;sex;Siblings;social;sociodemographic factors;sociodemographics;Socioeconomic Status;sound;Specificity;Sports;Stereotyping;Stress;Structure;substance use;Substance Use Disorder;substance use prevention;synergism;Testing;Theoretical model;Tobacco;Training;trait;Twin Multiple Birth;Twin Studies;Work

PROJECT_TITLE: Establishing if Music Engagement is a Protective Factor in Adolescent Substance Use Using Existing Longitudinal, Genetic, and Environmental Datasets

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-E (M1)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: Pancreatic cancer is a deadly cancer with increasing incidence for which no systematic efforts to reduce diagnostic delays exist. Our preliminary work shows that 40% of Veterans with pancreatic cancer experience diagnostic delays of  90 days and 40% experience missed opportunities to initiate or complete their diagnostic evaluation in a timely manner. Opportunities for more timely diagnosis of pancreatic cancer are possible in the VA, and the work put forth in this proposal tries to identify and transform these opportunities into decision support tools. In this project, we will: (1) identify potential missed opportunities for pancreatic cancer diagnosis; (2) develop electronic trigger (e-trigger) tools aimed at identifying high-risk patients with potential missed opportunities for pancreatic cancer diagnosis; and (3) assess local stakeholders’ views of facilitators and barriers to implementation of e-triggers for future application in clinical practice. These aims will be aligned with career development and training activities including formal coursework and a structured mentorship plan.

PI_NAMEs: KHALAF, NATALIA  (contact)

PROJECT_TERMS: Address;Affect;Algorithms;anti-cancer research;Area;cancer care;cancer diagnosis;Cancer Etiology;cancer type;career;career development;Caring;Cessation of life;Clinical;Clinical Informatics;clinical practice;cohort;Communication;comorbidity;Computer software;Coupled;Curative Surgery;Data;Development;Diagnosis;Diagnostic;Dimensions;Early Diagnosis;Educational Status;Effectiveness;effectiveness evaluation;effectiveness/implementation study;Electronic Health Record;Electronics;Engineering;Environment;Evaluation;Excision;experience;formative assessment;Frequencies;Future;Goals;Health;Health Personnel;Health Services;Health Services Research;Healthcare;Healthcare Systems;high risk;Human Resources;Hybrids;implementation barriers;improved;Incidence;Informatics;informatics tool;innovation;Interdisciplinary Study;Interview;Judgment;Knowledge;Link;Literature;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical Records;Medicine;Mentors;Mentorship;Methodology;novel;Outcome;pancreatic cancer patients;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Play;Predictive Value;Prevention;Process;Provider;Public Health Informatics;Random Allocation;Records;Research;Research Infrastructure;Research Personnel;Resources;Risk;Risk Factors;Role;Safety;Structure;Study models;support tools;Symptoms;System;Testing;Time;tool;Training Activity;Trust;United States National Academy of Sciences;Veterans;Work

PROJECT_TITLE: Health informatics approaches to reduce missed opportunities in diagnosis of pancreatic cancer

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

ORG_STATE: MA

PHR: There are about 40,000 Veterans experiencing homelessness, and another 300,000 at risk. Their health is generally poor, and their lives are shortened by 10 to 20 years. This project seeks to improve homeless Veterans' access to healthcare services and treatments. To do this, it is important to better understand Veterans' transitions into homelessness, or from one unstable situation to the next, such as from cohabiting with family or a friend to living in a homeless shelter. The knowledge of these transitions, especially from the perspective of the individuals experiencing them – such as their in-the-moment emotions, behaviors, and geographic movements, could inform interventions that prevent Veterans' rapid deterioration in housing or in health. This study examines the usefulness of smartphones to collect information from Veterans in near real- time as the transitions are occurring. It will lead to new programs for Veterans at risk of or experiencing homelessness to assist them before housing instability worsens, and before health crises occur.

PI_NAMEs: MCINNES, DONALD KEITH (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Appointment;barrier to care;Behavior;Cellular Phone;Clinical;Communication;Complex;cost;Data;Data Collection;Deterioration;Development;Early Intervention;Ecological momentary assessment;Ecology;Economics;Effectiveness;Electronic Health Record;Elements;Emergency department visit;Emotions;Enhancement Technology;Ethnography;Event;experience;Failure;Family;Focus Groups;Friends;Future;Geography;Global Positioning System;Goals;Health;health care availability;health care service;Health Priorities;health service use;Health Services;Health Services Accessibility;Healthcare;high risk;Homeless persons;homeless shelters;Homelessness;Housing;housing instability;Improve Access;improved;Individual;innovation;Intervention;Interview;Knowledge;Life Expectancy;Lived experience;Location;marginalization;Measures;Medical Records;Methodology;Methods;mHealth;mobile computing;Monitor;Moods;Movement;novel strategies;opioid use disorder;outreach;Overdose;Patients;Pattern;peer;Persons;Population;prevent;programs;Prospective Studies;Prospective, cohort study;Questionnaires;real time monitoring;Research;Research Methodology;Research Personnel;Resources;response;Risk;Services;Shelter facility;social;Social support;Social Work;Specialist;Structure;Suicide prevention;Surveys;System;Techniques;Technology;telehealth;Testing;theories;Time;tool;transitional housing;Translating;treatment adherence;Trust;Typology;usability;Veterans;video visit;virtual healthcare;Vulnerable Populations;willingness;Work

PROJECT_TITLE: Capturing the Dynamics of Homelessness through Ethnography and Mobile Technology

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: Rates of sexually transmitted infection (STI), especially gonorrhea and chlamydia, have increased dramatically over the past decade. However, screening remains suboptimal. Women are more vulnerable to the effects of STIs than men and are disproportionately affected by STIs. Several factors put women Veterans at higher risk for STIs as compared with both non-Veteran women and male Veterans. Few studies have examined the epidemiology of STIs in women Veterans and none has assessed health system responses to STIs or examined patterns of STI screening among women Veterans. To establish an appropriate and effective prevention plan, it is necessary to understand the current landscape of STI screening in VA. This study will assess and explore practice-, provider-, and patient-level correlates and barriers/facilitators to gonorrhea and chlamydia screening in VA women’s health. This information will be used to develop and pilot a clinical decision support tool to improve gonorrhea and chlamydia screening for women Veterans.

PI_NAMEs: KEDDEM, SHIMRIT  (contact)

PROJECT_TERMS: active duty;adverse outcome;Affect;Age;Area;Awareness;Behavior;Benchmarking;Big Data;career;career development;Caring;Centers for Disease Control and Prevention (U.S.);Characteristics;Chlamydia;Chlamydia Infections;chronic pelvic pain;clinical decision support;Clinical Services;cost effective intervention;Counseling;COVID-19;Data;Data Analyses;Detection;Development;Diagnosis;disorder prevention;Documentation;Early Diagnosis;Ectopic Pregnancy;effectiveness/implementation trial;Electronic Health Record;Eligibility Determination;Epidemiology;ethnic minority population;Evaluation;experience;Exposure to;Feedback;Foundations;Future;General Population;Gonorrhea;Guidelines;health assessment;Health Promotion;Health Services Research;Health system;Healthcare;Hepatitis;high risk;HIV;HIV Infections;Hysterectomy;improved;Infection;infection management;infection rate;Infertility;Informatics;innovation;Intervention;Interview;intimate partner violence;Investigator-Initiated Research;K-Series Research Career Programs;male;men;Methodology;Methods;Military Personnel;military women;multilevel analysis;Outcome;Patient Self-Report;patient-level barriers;Patients;Pattern;Pelvic Inflammatory Disease;Personal Satisfaction;pilot test;Play;post-traumatic stress;Predisposition;prevent;Prevention;Primary Care;primary care clinic;Provider;racial minority;Recommendation;Recording of previous events;Research;research and development;Research Personnel;Research Proposals;response;Risk;Risk Factors;Role;routine screening;screening;screening guidelines;sexual and reproductive health;sexual trauma;sexual violence;sexually active;Sexually Transmitted Diseases;Site;Specific qualifier value;substance use;support tools;Symptoms;Testing;therapy design;tool;Training;trend;United States Preventative Services Task Force;Unmarried;uptake;usability;user centered design;Veterans;Woman;women patients;Women's Health;Women's Health Services;women's reproductive health;Work

PROJECT_TITLE: Assessing Trends in STI Screening among Women Veterans in the VHA


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Cognitive processing therapy (CPT) and prolonged exposure therapy (PE) were widely disseminated as recommended posttraumatic stress disorder (PTSD) treatments. However, post-9/11 Veterans with PTSD rarely initiate CPT or PE, especially as an initial treatment. Little research has explored the combinations and sequences of psychosocial and medication treatments that Veterans receive (“treatment sequences”). One common and understudied treatment sequence begins with stabilization treatment, which is designed to prepare Veterans for CPT or PE. There is a significant research gap in understanding how treatment sequence affects initiation of CPT or PE. The proposed research is an innovative, mixed-methods approach to assessing the impact of variability in treatment sequence, including stabilization treatment, on initiation of CPT or PE and applying this knowledge by developing a health services intervention that facilitates timely transition to CPT or PE. Research aims can improve PTSD treatment by increasing initiation of and reducing disparities in CPT/PE.

PI_NAMEs: HOLDER, NICHOLAS  (contact)

PROJECT_TERMS: acceptability and feasibility;access disparities;Advocate;Affect;Area;Base Sequence;biopsychosocial;career;Caring;Characteristics;Clinical Practice Guideline;Cognitive;Collaborations;Combination Medication;common treatment;comparison intervention;Coping Skills;Data;Decision Making;design;Development;Diagnosis;Disparity;disparity reduction;Effectiveness;Electronic Health Record;Emotional;Ensure;ethnic minority;Evaluation;experience;Future;Goals;group intervention;Group Psychotherapy;hazard;Health Services;Health Services Accessibility;Health Services Research;Hybrids;implementation research;implementation science;improved;improved outcome;innovation;interest;Intervention;Interview;Knowledge;Longitudinal cohort;men;Mental Health;Methodology;Methods;novel strategies;Outcome;Patient Preferences;Pharmaceutical Preparations;pilot trial;post 9/11;Post-Traumatic Stress Disorders;pragmatic trial;primary outcome;Procedures;psychosocial;Psychotherapy;Qualitative Methods;racial minority;Randomized;Recommendation;Recovery;Research;Research Methodology;Research Personnel;Risk;Sampling;secondary outcome;service intervention;Services;shared decision making;Site;sociodemographic disparity;sociodemographics;success;Suicide prevention;Testing;therapy development;Time;Training;Translating;treatment as usual;treatment disparity;treatment research;Veterans;Veterans Health Administration;Woman;Work

PROJECT_TITLE: Improving Care for Veterans by Understanding and Facilitating Transition to Recommended PTSD Treatment


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: Cardiovascular disease (CVD) is the most common cause of death in Veterans. CVD-related deaths are over twice as likely in patients with comorbid alcohol misuse, due in part to alcohol misuse directly exacerbating several modifiable factors that lead to CVD. 9-32% of all Veterans are in this high-risk, preventable population of comorbid alcohol misuse and elevated, modifiable CVD risk. No treatments have targeted this population. Current VA/DoD treatment guidelines for comorbid alcohol misuse in primary care are ineffective. Because alcohol misuse is often a recurrent problem, and the dominant driver of treatment recommendations, timely treatment of these Veterans’ CVD risk in conjunction with alcohol misuse treatment in may be critical for developing clinical traction with CVD risk. This research is highly relevant to Veteran health, VHA priorities, and HSR&D priorities because the combined intervention targets and telehealth approaches address critical gaps in treatment timeliness and access for this high-risk population.

PI_NAMEs: BLALOCK, DANIEL V (contact)

PROJECT_TERMS: acceptability and feasibility;Address;alcohol comorbidity;alcohol intervention;alcohol misuse;alcohol screening;alcohol services;Alcohols;barrier to care;Behavior Therapy;Behavioral;behavioral health;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;career;Caring;Cause of Death;Cessation of life;Characteristics;Clinic;Clinical;Clinical Data;clinical effect;Clinical Trials;clinically significant;Cognitive Therapy;cohort;comorbidity;comparative effectiveness trial;cost effectiveness;Data;design;Development;Diet;drinking;Effectiveness;Electronic Health Record;Feedback;follow-up;Foundations;Funding;Future;Glean;Goals;Habits;Health;Health behavior;Health Services;Health Services Accessibility;Heavy Drinking;high risk;high risk population;implementation science;Improve Access;improved;innovation;Intervention;intervention effect;intervention refinement;Interview;Measures;medication compliance;Methodology;Methods;mHealth;mhealth interventions;military veteran;Modality;Modeling;modifiable risk;novel;operation;Outcome;Patient Preferences;Patients;Pattern;Perception;physical inactivity;Physicians;Population;Primary Care;primary outcome;Process;Provider;Randomized;Recommendation;recruit;Recurrence;Relapse;Research;Research Personnel;Risk Reduction;secondary outcome;service utilization;skills;Smoking;stakeholder perspectives;substance use;System;Target Populations;telehealth;telephone coaching;Testing;therapy development;Time;Traction;Training;treatment guidelines;Underserved Population;Veterans;Visit

PROJECT_TITLE: Telehealth Treatment of Veterans with Alcohol Misuse at Risk for Cardiovascular Disease


ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Sarah L. Krein, PhD, RN is an active and productive health services and nurse researcher. She uses her clinical knowledge and research expertise to conduct and collaborate on studies to improve healthcare safety, quality, and effectiveness as well as Veteran health outcomes. She also works with clinician and non-clinician scientists who are beginning their research careers, assisting them in learning new research skills and supporting them as they move on to leading their own research studies. The support provided by the VA senior research career scientist award will allow her to continue to use her research expertise and experience to continue conducting research that improves VA healthcare delivery and patient safety, educate new researchers, work with local, national and international collaborators and contribute to activities that support the VA research, education and care delivery missions.

PI_NAMEs: KREIN, SARAH  (contact)

PROJECT_TERMS: Acute;Address;Antibiotics;Area;Award;Behavior;Benzodiazepines;Books;care delivery;Care given by nurses;care outcomes;career;Caring;catheter associated UTI;Catheters;Chronic;chronic pain;chronic pain management;Clinical;clinical care;clinical practice;Collaborations;Communication;Communities;community living;Complex;complex chronic conditions;design;disease transmission;Doctor of Philosophy;Education;Effectiveness;Ensure;Epidemiology;European Union;Evaluation;experience;Funding;Generations;Grant;Health;health care delivery;health care settings;health economics;Health Services;Health Services Research;Healthcare;Healthcare Systems;Heart Arrest;Hospitals;implementation research;improved;Infection prevention;infection rate;innovation;Interdisciplinary Study;interest;Internal Medicine;International;Investigation;Japanese;Journals;Knowledge;Learning;Long-Term Care;Medical center;Medical Research;Medicine;Mentors;Methodology;Methods;Michigan;Mission;multidisciplinary;New England;Nosocomial Infections;novel strategies;Nurses;Nursing Homes;Operative Surgical Procedures;Outcome;Outcomes and Health Services Research;Patient Care;patient safety;Patient-Focused Outcomes;Patients;Performance;Peripheral;personal protective equipment;prevent;Prevention;prevention practice;Prevention program;Principal Investigator;Productivity;programs;Proton Pump Inhibitors;provider communication;Publications;Publishing;Qualitative Methods;Quality of Care;Research;Research Design;Research Methodology;Research Personnel;research study;Research Technics;Research Training;Resuscitation;Risk;Risk Reduction;Safety;safety practice;Saints;Science;Scientist;Services;skills;Source;Technology;Text;Time;Training;Universities;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Research Career Scientist Award

STUDY_SECTION_NAME: HSR-7 Capacity Building[HSR7]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: NEW ORLEANS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it utilizes a new approach to advance understanding of how the brain regulates behavioral states transitions associated with fear and panic, and will thereby provide vital information about the root cause of debilitating psychiatric illnesses, such as post-traumatic stress, panic, and specific phobia. This is directly relevant to the NIH’s mission pertaining to reducing illness and disability and of laying the foundation for ad- vances in disease treatment and prevention.

PI_NAMEs: FADOK, JONATHAN P (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: addiction;Alprazolam;Amygdaloid structure;Anxiety;Behavior;Behavior Control;Behavioral;Behavioral Paradigm;Brain;Calcium;Carbon Dioxide;Cells;Characteristics;comorbidity;Complex;Corticotropin-Releasing Hormone;Data;delivery vehicle;design;Development;disability;Disease;Emotional;emotional behavior;extracellular;Foundations;Freezing;Fright;Glutamates;Goals;Hippocampus;Hypothalamic structure;Image;in vivo;innovation;Knowledge;Mediating;Mental disorders;midbrain central gray substance;Mission;Modeling;Monitor;Mus;neural;neural circuit;neural correlate;Neurobiology;neuromechanism;neuronal circuitry;Neurons;Neurosciences;novel;novel strategies;optogenetics;Output;Panic;Panic Disorder;Pathway interactions;Pattern;Perception;Population;Population Projection;Positioning Attribute;post-traumatic stress;Post-Traumatic Stress Disorders;Prevention;Psychological Theory;Public Health;Regulation;Research;response;Role;Source;Specific Phobia;Stimulus;Structure;Substance Use Disorder;System;Testing;theories;Therapeutic;Trauma;United States National Institutes of Health;Viral Vector;Xanax

PROJECT_TITLE: Neural circuits regulating flight and panic behavior.

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: 8. Project Narrative Adolescence is an “age of risk” for the emergence of major depressive disorder (MD), a major public health problem. Using an innovative biobehavioral high-risk approach with a prospective longitudinal design, this application will examine bidirectional relationships between peripheral inflammation and multimodal reward function and their joint prediction of first onset of MD and increases in depression symptoms, particularly anhedonia. It will provide critical tools for identifying vulnerabilities to MD, integrate two separate research traditions to increase our understanding of specific etiological pathways underlying MD, and facilitate development of behavioral and biological interventions for ameliorating reward processing and inflammatory abnormalities that contribute to MD.

PI_NAMEs: ALLOY, LAUREN BERSH (contact);NUSSLOCK, ROBIN

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: 15 year old;Adolescence;Adolescent;Age;Anhedonia;Attenuated;Behavior;behavior measurement;Behavior Therapy;Behavioral;biobehavior;Biological;Birth History;Blood;Brain;child depression;Childhood;Chronic;Code;Corpus striatum structure;cytokine;depressive symptoms;design;Development;Diagnostic;Diet;Dimensions;dysphoria;Etiology;Event;Excision;Failure;Fatty acid glycerol esters;Feedback;follow-up;Foundations;functional MRI scan;Generations;high risk;Immune;Immune signaling;Immune system;indexing;Inflammation;Inflammation Mediators;Inflammatory;innovation;Intervention;Interview;Joints;Life;Literature;longitudinal design;Longitudinal Studies;Major Depressive Disorder;Measures;Mediating;Mediator;Mental Depression;Modeling;multimodality;network models;neural;Neuroimmune;ninth grade;novel;Onset of illness;Participant;pathogen;Pathway interactions;Patient Self-Report;Peripheral;persistent symptom;predicting response;Prevalence;prevent;prospective;Public Health;Recording of previous events;Research;Resources;reward processing;Rewards;Risk;Risk Marker;Sampling;Signal Transduction;Sleep disturbances;social;Specific qualifier value;Stress;stressor;substance use;sugar;Symptoms;synergism;System;Tail;Testing;Time;tool;Unhealthy Diet;Work;wound healing

PROJECT_TITLE: Integrated Reward-Inflammation Model of First Onset of Major Depression in Adolescence

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric;Prevention;Violence Research

ORG_CITY: HERSHEY

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE This Administrative Supplement application is to establish a fully reliable learning management system (LMS) and the corresponding research database needed to fulfill the aims of our current 5-year randomized controlled trial to determine how best to sustain knowledge about child abuse and its reporting. This LMS and research database (which will include research data dashboards, analytic functionality, and multiple reporting modalities) will support iLookOut's evidence-based mandated reporter training and follow-up interactive micro-learning course about how to protect at-risk children and support them and their families. In so doing, this supplement also will help ensure continued nationwide delivery of iLookOut programs to Head Start through the end of the grant period (anticipated to be July 31, 2027).

PI_NAMEs: LEVI, BENJAMIN H. (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Active Learning;Administrative Supplement;Adult;Age;American;Attitude;Awareness;behavior change;behavior measurement;Categories;Cessation of life;Child;Child Abuse;Child Care;Cognitive;cost;data dashboard;data integrity;Databases;early childhood;Education;Educational Intervention;efficacy evaluation;Emotional;Ensure;Epidemic;evidence base;Evidence based intervention;Family;Feedback;follow-up;Grant;Head Start Program;improved;innovation;Intervention;Knowledge;Learning;maladaptive behavior;maltreatment;Mental Health;Modality;Modeling;Multimedia;Nervous System Trauma;online intervention;physically handicapped;Problem Solving;programs;Randomized, Controlled Trials;recruit;Reporter;Reporting;Research;Risk;Sexual abuse;simulation;System;Target Populations;Training;Victimization

PROJECT_TITLE: iLookOut for Child Abuse: Micro-learning to improve knowledge retention


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: Nashville

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Preteen suicide is a growing public health crisis, and the substantially greater risk for suicidal thoughts and behaviors reported among sexual and gender minority (SGM) preteens is concerning. Consistent with NIMH programmatic priorities, this project will deploy an innovative mixed-methods approach incorporating advisory board and expert feedback, measurement development, and longitudinal data collection and analysis to study risk and protective factors for suicide in SGM preteens. Given the disproportionate risk for suicide among SGM preteens and the dearth of prospective research involving this high-risk population, this project represents a novel scientific advancement to inform suicide prevention.

PI_NAMEs: CLARK, KIRSTY A (contact)

PROJECT_TERMS: 13 year old;14 year old;Academy;Address;Adolescence;Adolescent;Adult;Age;aged;American;Attitude;Behavior assessment;Brain;bullying;Caregivers;Cause of Death;cisgender;cognitive development;cognitive interview;cohort;Communities;community involvement;community partners;computerized;Consensus;Data Analyses;Data Collection;Development;Disclosure;Disparity;educational atmosphere;Enrollment;Ensure;Equation;Ethics;Ethnic Origin;experience;Exposure to;Face;Family;Feedback;Feeling suicidal;Foundations;Gender Identity;gender minority community;gender minority group;gender minority health disparity;gender minority youth;Goals;Health equity research;Heterosexuals;high risk;high risk population;Individual;infancy;innovation;Knowledge;Laws;Legal;Life Cycle Stages;Longitudinal Studies;Maps;Measurement;Measures;meetings;member;Methods;Modeling;National Institute of Mental Health;National Institute on Minority Health and Health Disparities;novel;Parents;Participant;Patient Self-Report;Pediatrics;peer;Phase;Policies;Practice Guidelines;preadolescence;Process;prospective;Prospective cohort;protective factors;Psychometrics;Puberty;Public Health;racial difference;Recording of previous events;recruit;Reporting;Research;Research Personnel;resilience;response;Risk;Risk Assessment;Risk Factors;Sampling;Science;Scientific Advances and Accomplishments;Sexual and Gender Minorities;sexual minority;sexual minority group;sexual minority youth;social;social media;social stigma;sound;Stress;stressor;Subgroup;suicidal behavior;suicidal risk;Suicide;Suicide prevention;Surveys;Teenagers;Testing;Time;transgender;trend;young adult;Youth

PROJECT_TITLE: Measuring and Mapping Trajectories of Risk and Resilience for Suicidal Thoughts and Behaviors in Sexual and Gender Minority Preteens

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-E (05)]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Prevention;Tobacco;Tobacco Smoke and Health

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to the public health because the incidence of Crohn’s disease (CD) is on the rise, represents a major cost measured by both patient quality of life and economic burden. Genome-wide association studies have identified >100 susceptibility loci for CD, and functional studies to determine the role of these susceptibility genes are needed to develop new therapies. We propose to investigate the molecular mechanisms by which LRRK2 (a recently identified CD susceptibility gene) affects gut innate immunity, and how additional CD-relevant gene-environment interaction can activate LRRK2 kinase.

PI_NAMEs: LIU, TA-CHIANG  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Acetylcysteine;Address;Affect;Air;Antiinflammatory Effect;Antioxidants;Autophagocytosis;Biological Assay;Biology;Bone Marrow;catalase;Cell Density;cell type;Cells;cellular targeting;cigarette smoke;cigarette smoking;Clinic;clinically relevant;Complex;Cost Measures;Crohn's disease;cytokine;Data;Defect;Development;Disease;Disease Progression;Disease susceptibility;Dose;Economic Burden;Electron Transport;Environmental Risk Factor;enzyme activity;Enzyme-Linked Immunosorbent Assay;Enzymes;Epithelial Cells;Epithelium;Exposure to;gastrointestinal epithelium;gene environment interaction;Gene Expression;Genes;Genetic;genetic risk factor;genome wide association study;Genotype;Genus Hippocampus;Glutathione;Goals;gut homeostasis;gut inflammation;Homeostasis;Hyperactivity;Incidence;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;inhibitor;innate immune function;innovation;insight;interest;Intervention;intestinal epithelium;Intestines;kinase inhibitor;Knock-out;Knowledge;Link;Liquid substance;LRRK2 gene;Macrophage;Measures;Mediator;Mitochondria;Modeling;Molecular;Molecular Target;Morphology;Mucosal Immunity;Mucous Membrane;Mus;NADPH Oxidase;Natural Immunity;novel;novel therapeutics;Organoids;Paneth Cells;Parkinson Disease;Pathogenesis;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Phagocytes;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Physical condensation;Predisposition;prevent;Process;Production;Public Health;Quality of life;Reactive Oxygen Species;Regulation;Reporting;Repression;Research;Risk;Role;Sampling;Shapes;Single Nucleotide Polymorphism;Small Intestines;Smoke;Smoking;stem cell differentiation;stem cells;Superoxide Dismutase;Susceptibility Gene;targeted treatment;Testing;Therapeutic;therapeutic target;transcriptomics;Translating;translational approach;Western Blotting;Work

PROJECT_TITLE: Macrophage LRRK2 activity regulates gut epithelial homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-C (M1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Mental Health;Neurodegenerative;Neurosciences;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE There is growing evidence linking age-related hearing loss (ARHL) with cognitive impairment and the increased risk of Alzheimer’s disease and related dementias. Recent research demonstrated an association between the severity of hearing loss and disability in routine daily activities. The goal of this study is to understand the effect of cochlear implants and hearing aids using real-world data documenting daily performance in study subjects’ natural environments to prevent the onset of cognitive impairment, or progression from mild cognitive impairment to dementia in people with ARHL.

PI_NAMEs: DUNN, CAMILLE C (contact);SHULMAN, LISA M.

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acoustic Nerve;Acoustic Stimulation;Activities of Daily Living;Address;Adult;Age;age effect;age related;Age Years;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Auditory;Auditory system;Bypass;Caring;Cellular Phone;cerebral atrophy;Clinical;clinical decision support;Cochlea;Cochlear Implants;Cognition;Cognitive;cognitive function;cognitive performance;cohort;Communication;Data;data sharing;Dementia;dementia risk;Ecological momentary assessment;Effectiveness;Elderly;Emotional;Environment;Environmental Risk Factor;Evaluation;evidence base;falls;frailty;functional disability;Goals;Health;Hearing;Hearing Aids;hearing disability;hearing impairment;hearing loss risk;Household;human old age (65+);Impaired cognition;Implant;improved;Individual;Intervention;Knowledge;Laboratories;large scale data;Life Style;Measures;Memory;Mental Depression;Mental Health;Meta-Analysis;mild cognitive impairment;Modeling;modifiable risk;Neurology;Neuropsychological Tests;Neuropsychology;normal hearing;older adult;Outcome;Outcome Assessment;Outcome Measure;Patient Outcomes Assessments;Patients;Performance;Peripheral;Personal Satisfaction;personalized predictions;Persons;Poverty;precision medicine;predictive modeling;Presbycusis;Prevalence;prevent;Prevention;primary outcome;psychosocial outcome;psychosocial wellbeing;Qualifying;Randomized, Controlled Trials;Relative Risks;Research;Resources;Risk;Risk Factors;Severities;social engagement;Social Interaction;Social isolation;sound;Study Subject;Subgroup;System;systematic review;Time;Translating;Visual

PROJECT_TITLE: The Effectiveness of Cochlear Implants in Real-World Settings for Mild Cognitive Impairment and Dementia in Older Adults with Age-Related Hearing Loss

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

ORG_STATE: NY

PHR: NARRATIVE Our overall goal is to uncover the etiology of prostate cancer racial disparities for African American prostate cancer patients. We expect that the rDNA clock will become a valuable surveillance marker to assess risk of early onset prostate cancer African American cancer patients, and the research proposed here will provide evidence to support the wider application of the rDNA clock as a biomarker to monitor the risk of age-associated disease in this unique population of cancer patients.

PI_NAMEs: LEMOS, BERNARDO ;OHM, JOYCE ELLEN;WOLOSZYNSKA-READ, ANNA  (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;Address;Adoption;African American;African ancestry;Age;Age Years;age-related disease;Aging;aging biomarker;aging clocks;American;Area;Assessment tool;biobank;Biological;biological age;Biological Markers;bisulfite sequencing;Blood Banks;Blood specimen;Calendar;cancer diagnosis;Cancer Patient;cancer type;Cell Proliferation;Characteristics;Chronology;Data;data repository;Diagnosis;Diet;dietary;Disease;disorder risk;Disparity;DNA Methylation;early onset;Environmental Exposure;Environmental Risk Factor;Epigenetic age;epigenetic aging;epigenetic clock;epigenome;Ethnic Origin;Ethnic Population;Etiology;European;Evaluation;Event;Exercise;Exhibits;Future;Genes;Genetic;genome-wide;Gleason Grade for Prostate Cancer;Goals;Growth;Health;health disparity;high risk;Hypermethylation;Individual;Individual Differences;insight;Intervention;Knowledge;Late-Onset Disorder;Life;life span;Link;Lived experience;Longevity;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Measures;men;Metabolism;Methylation;Monitor;mortality;Patients;Performance;Population;Predictive Value;Promoter Regions;prostate cancer risk;Prostate-Specific Antigen;Prostatectomy;PSA level;Race;racial disparity;racial population;Reproducibility;Research;Ribosomal DNA;Risk;Risk Assessment;social;Socioeconomic Status;The Cancer Genome Atlas;Tumor Volume;Validation;Work

PROJECT_TITLE: Epigenetic aging as a driver of racial disparities in early onset prostate cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-P (M1)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE  An increase in the concentration of reactive oxygen species has been thought to be a mechanism promoting development of the biology of aging for over half a century, however, technical limitations have until recently substantially limited investigation of this hypothesis. This proposal will develop preliminary findings that identified specific targets of reactive oxygen species which influence aging phenotypes through post-translational regulation of proteins by cysteine oxidation. Upon completion, this study will establish mechanism(s) and produce resources outlining how reactive oxygen species influence the biology of aging which can leveraged to develop new strategies to promote healthy aging.

PI_NAMEs: MORROW, CHRISTOPHER SCOTT (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Age;age related;age related changes;age-related disease;aged;Aging;Area;Biological;Biological Assay;Biological Models;Biological Process;Biology of Aging;Budgets;Caenorhabditis elegans;Cells;Cellular biology;Communication;Cysteine;Data;Data Set;Development;Disease;Event;experience;fitness;Future;Genetic;Grant;Health;healthspan;healthy aging;Human;improved;In Vitro;inorganic phosphate;insight;Intervention;Investigation;Life Expectancy;life span;Link;Longevity;macromolecule;Maintenance;Measures;Mentors;Metabolism;Molecular;Molecular Conformation;multicatalytic endopeptidase complex;mutant;Mutate;Organism;Oxidants;oxidation;Oxidation-Reduction;pharmacologic;Phenotype;Post-Translational Regulation;Prevalence;programs;Protein Analysis;protein degradation;Proteins;Proteome;Proteomics;proteostasis;Public Health Schools;rate of aging;Reactive Oxygen Species;Reducing Agents;Regulation;Research;Research Personnel;Resources;response;Sampling;Scientist;Site;skills;Techniques;Testing;theories;Titrations;tool;Training;Work;Writing

PROJECT_TITLE: Harnessing Redox Regulation of Proteasome Function to Promote Healthy Aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative Focal cortical dysplasia (FCD) is a common cortical malformation associated with medically refractory epilepsy and most frequently caused by variants in subunits of the GATOR1 complex (a negative regulator of mTOR): DEPDC5, NPRL3, and NPRL2. The least studied of these variants is NPRL2 and in this proposal we aim to define the pathophysiological consequences of Nprl2 KO in vivo and in vitro. Using a mouse model of FCD we will define the morphological and functional changes that occur due to Nprl2 KO-induced mTOR pathway hyperactivation as well as investigate the transcriptomic changes that occur downstream of mTORC1 that may produce MCD and seizures.

PI_NAMEs: IFFLAND, PHILIP HENRY (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;AKT3 gene;Amino Acids;Animals;Architecture;autism spectrum disorder;Binding;Biological Assay;brain malformation;brain tissue;Cell Aggregation;cell cortex;Cell Size;cell type;Cells;Cellular Morphology;Cerebral cortex;Childhood Neurological Disorder;Complex;Cortical Dysplasia;Cortical Malformation;CRISPR/Cas technology;Defect;Dendrites;Dependence;Development;Developmental Delay Disorders;differential expression;Disease;Dissociation;EIF4EBP1 gene;Electroencephalography;Electroporation;Ephrin-A5;Epilepsy;experimental study;Fluorescence;FRAP1 gene;Future;Genes;genetic variant;Growth;Harvest;Image;Image Cytometry;Immunochemistry;immunocytochemistry;in utero;In Vitro;in vivo;Individual;Intellectual functioning disability;Intractable Epilepsy;Knowledge;Lesion;Link;Lysosomes;Manuals;Measurement;Medical;Modeling;Monitor;Morphology;mouse model;mTOR Inhibitor;mTORopathies;Mus;Neurodevelopmental Disorder;neuronal cell body;Neurons;new therapeutic target;novel;Operative Surgical Procedures;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphorylation;PIK3CG gene;Plasmids;pre-clinical;Precision therapeutics;preclinical study;Process;Protein Subunits;Proteins;Proto-Oncogene Proteins c-akt;pup;Regulator Genes;Resected;Resistance;response;Role;Seizures;Signal Transduction;single nucleus RNA-sequencing;Sirolimus;Somatic Mutation;Specimen;Starvation;STAT3 gene;Structure;Testing;transcriptome;transcriptomics;TSC2 gene;Variant;Western Blotting

PROJECT_TITLE: The role of NPRL2 loss in focal cortical dysplasia


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The lack of objective, clinically relevant brain-based biomarkers of social engagement hinders our ability to test novel interventions and treatments to improve functioning in autistic children. The proposed study will test how several promising measures of brain activity in young, autistic children relate to core features such as social attention, social interaction with caregivers, and standardized clinical assessments of social communication functioning. Results from this study will give us tools to better understand heterogeneity in autism as well as more effectively evaluate response to therapies and treatments.

PI_NAMEs: BEY, ALEXANDRA LYNDON (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 6 year old;Affect;autism spectrum disorder;autistic;autistic children;Back;Behavior;Behavioral;Biological Markers;biomarker identification;Brain;brain based;career;career development;Caregivers;Centers of Research Excellence;Characteristics;Child;Child Psychiatry;Clinical assessments;Clinical Research;Clinical Trials;clinically relevant;Code;connectome;Coupled;critical period;Data;design;Detection;Development;Doctor of Philosophy;early childhood;Early Diagnosis;Early Intervention;Early intervention trials;early-career faculty;Electroencephalography;Electrophysiology (science);endophenotype;Environment;experience;Eye;Family;follow-up;Foundations;functional improvement;Funding;Future;gaze;Goals;Grant;Heterogeneity;Human;improved;Individual;Individual Differences;individuals with autism spectrum disorder;Infrastructure;Interdisciplinary Study;Intervention;Joints;Knowledge;Lead;Learning;Machine Learning;machine learning method;Measures;Mental disorders;Mentors;Mentorship;Methodological Studies;model of autism spectrum disorder;Modeling;mouse model;movie;multimodality;Mus;National Institute of Mental Health;neurophysiology;Neurosciences;Neurosciences Research;novel;Outcome Measure;Participant;Pattern;Physicians;Population;pre-clinical;Pre-Clinical Model;preclinical study;Productivity;programs;Psychiatrist;Psychiatry;recruit;Research;Research Priority;response;Scheme;Scientist;screening;secondary analysis;skill acquisition;skills;social;social attention;social communication;Social Development;social engagement;Social Interaction;social skills;Social skills development;Standardization;Statistical Data Interpretation;Statistical Methods;statistics;Stimulus;Stratification;Supervision;synergism;Testing;therapeutically effective;Time;tool;Training;Translational Research;Translations;treatment response;United States National Institutes of Health;Universities;Variant;Work

PROJECT_TITLE: Electrophysiological biomarkers of social engagement in autism

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Data Science;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Suicide

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE The Preteen Suicide Risk and Protective Factors Data Coordinating Center (DCC) will work with six research projects to agree on and publish common data elements designed to help researchers identify factors that put children ages 8–12 at risk for suicidal thoughts and behaviors. The DCC will help coordinate information produced by these research projects to make data available for other researchers through the National Institute for Mental Health Data Archive.

PI_NAMEs: SAAVEDRA, LISSETTE MARIA (contact)

PROJECT_TERMS: Age;age group;Agreement;archive data;Back;Cause of Death;Child;Collaborations;Common Data Element;Communication;Communities;community engagement;Complex;computer infrastructure;Consensus;contextual factors;Coordination and Collaboration;Data;Data Aggregation;Data Analyses;data archive;Data Collection;Data Coordinating Center;data dissemination;data format;data harmonization;data infrastructure;data integration;data interoperability;data management;data platform;Data Science;Data Set;data sharing;data structure;data submission;design;Development;Ensure;experience;Feeling suicidal;Fostering;Funding;Goals;Growth;improved;Individual;Informatics;International;Knowledge;Leadership;lens;Measures;meetings;member;Methods;Minority;Modeling;Monitor;multidisciplinary;multimodality;National Institute of Mental Health;open data;operation;Practice Guidelines;preadolescence;Principal Investigator;Process;protective factors;Publishing;Reporting;Research;Research Personnel;Research Project Grants;resilience;Resources;Risk;Risk Factors;Running;Schedule;Science;Series;Site;social;Structure;suicidal behavior;suicidal risk;Suicide;suicide rate;Sum;Techniques;Technology;Teleconferences;timeline;United States National Institutes of Health;webinar;Work;Youth


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The R21 project collects and analyzes high-frequency data on within-year changes in debt holdings and self-reported health. Short-term fluctuations in debt may be an independent determinant of poor health that is currently missing from our understanding of how financial standing impacts health inequalities. Our proposed study will be the first to capture within-year debt fluctuations and evaluate their relationship to generalized stress, anxiety, and depression; findings will inform policies to support the health and well-being of lower-income populations.

PI_NAMEs: AMORIM, MARIANA ;BEA, MEGAN D (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Address;Adult;American;Anxiety;Area;Attention;Cellular Phone;Complex;Consumption;Data;Data Collection;design;Development;Discipline;Economic Policy;Economics;experience;Family;Family Policy;Frequencies;Funding;Health;health assessment;health inequalities;Heterogeneity;Income;Individual;insight;interest;Investigation;Link;Literature;Low income;Low Income Population;Measurement;Measures;Mental Depression;multidisciplinary;novel;Occupational activity of managing finances;Outcome;Participant;Patient Recruitments;Patient Self-Report;Pattern;Personal Satisfaction;Persons;Policies;Poverty;Prevalence;Public Health;Race;racial disparity;recruit;Regression Analysis;Research;Role;Sampling;Self Assessment;Shapes;Shock;Social Network;Source;standard measure;Statistical Methods;Stress;stress reduction;stressor;success;Surveys;Text;Text Messaging;Time;United States National Institutes of Health;Variant;Wisconsin

PROJECT_TITLE: Within-Year Debt Fluctuations, Stress, and Health

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]