NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Finding a permanent cure for people living with HIV is a key priority of the NIH and requires broad and inclusive basic science research into how the virus remains latent in people on antiretroviral therapy. However, although over 70% of HIV patients live in Africa, very little of the basic science of cure research involves African patients who are predominantly women, a key gap that needs urgent remedy. This D43 training supplement will support a post-doctoral fellow and a master's level trainee to perform basic science and cure research relevant to women living with HIV.

PI_NAMEs: KYEI, GEORGE  (contact);SHAN, LIANG

PROJECT_TERMS: Affect;Africa;African;African Women;Basic Science;Caucasians;CD4 Positive T Lymphocytes;co-infection;Collaborations;design;Doctor of Philosophy;Enrollment;Europe;Exclusion;experience;Funding;Genetic Transcription;Ghana;graduate student;Grant;Hepatitis;HIV;Human Papillomavirus;Immunologics;Laboratory Research;Medical Research;memory CD4 T lymphocyte;men;Mentors;Mentorship;parent grant;Patients;Persons;Postdoctoral Fellow;programs;Proviruses;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Scientist;skills;Students;success;T cell response;Training;Training Programs;Tuberculosis;United States National Institutes of Health;Universities;Viral;Washington;Woman

PROJECT_TITLE: HIV Basic Science and Cure Research Training for Scientists at the University of Ghana (H-Cure-RT)


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Genetics;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: IOWA CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: RELEVANCE (See instructions): There is a need to uncover the etiological mechanisms underlying the association between preterm birth and impaired neurodevelopment, both to improve the identification of the preterm infants who are at higher risk for impaired neurodevelopment and to inform efforts towards neurodevelopmental interventions. This project will provide much needed data to pave the way for novel opportunities for neurodevelopmental prevention and intervention efforts for preterm infants, and thus, decrease the incidence of neurodevelopmental disabilities and morbidities.

PI_NAMEs: MOMANY, ALLISON MARIE (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 2 year old;37 weeks gestation;Affect;Age;Biological;biological adaptation to stress;Birth;Blood Pressure;Buffers;career;caregiver stress;Caregivers;Child;Clinic;Clinical;Clinical Nursing Research;Complex;Data;Development;Developmental Process;Distress;DNA Methylation;early childhood;economic cost;Educational workshop;effective intervention;Environment;Epigenetic Process;Etiology;experience;extreme prematurity;Faculty;follow-up;Future;Genes;genetic analysis;Gestational Age;Goals;Heart Rate;hemodynamics;high risk;high risk infant;Hospitalization;Human Genetics;Hydrocortisone;Hydroxyprogesterone;Impairment;improved;Incidence;indexing;infancy;Infant;Infrastructure;Institution;Instruction;Intervention;Iowa;Knowledge;laboratory experience;Lead;Level of Evidence;Life;Link;Literature;longitudinal analysis;Measures;Mediating;member;Mentorship;Methods;Modification;Molecular Genetics;Morbidity - disease rate;National Institute of Child Health and Human Development;neglect;Neonatal;neonatal morbidity;Neonatology;neurodevelopment;Neurodevelopmental Deficit;Neurodevelopmental Disability;Neurodevelopmental Disorder;novel;Outcome;Oxygen;Phase;Physiological;Physiology;premature;Premature Birth;Premature Infant;Prevention;Procedures;professor;programs;psychological distress;Research;Research Personnel;research study;Research Support;Risk;Scientist;Severities;skill acquisition;skills;Strategic Planning;Stress;success;tenure track;Training;Translating;United States;Universities;Variant

PROJECT_TITLE: Neonatal Stress in Very Preterm Infants:  Longitudinal Effects on Epigenetics and Neurodevelopment

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE A thorough elucidation of the transcriptional determinants and molecular heterogeneity of Barrett’s esophagus will uncover novel avenues to detect and treat these precancerous metaplasias to ultimately prevent the devel- opment of esophageal adenocarcinoma. Here, I will investigate the roles of two pioneering transcription factors involved in GI tract patterning, SOX2 and CDX2, in Barrett’s esophagus development and maintenance using novel genetic mouse models and my unique biobank of human-derived Barrett’s esophagus organoids. These innovative studies will deﬁne a stepwise transcriptional reprograming towards an intestinal phenotype seen in Barrett’s esophagus, and establish a multi-omic pipeline to further elucidate the heterogeneity and molecular subtypes of Barrett’s esophagus.

PI_NAMEs: JIN, RAMON  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Address;Adult;Animal Model;Award;Barrett Esophagus;Bile Acids;biobank;Bioinformatics;Biological Assay;career development;CDX2 gene;Cellular biology;Characteristics;Chronic;college;Columnar Epithelium;Columnar Metaplasia;Community Integration;Culture Techniques;Data;deoxycholate;Development;Development Plans;Doctor of Medicine;Doctor of Philosophy;Ensure;Enterobacteria phage P1 Cre recombinase;epigenomics;Epithelium;Equilibrium;Esophageal Adenocarcinoma;Esophagus;experience;experimental study;Fellowship;Foundations;Funding;gastroesophageal cancer;Gastroesophageal reflux disease;gastrointestinal;Gastrointestinal tract structure;Gene Modified;Genetic;Genetic Transcription;Genetically Modified Animals;Genomics;Grant;Grant Review;Growth;Hematology;Heterogeneity;Hindgut;Histologic;Homeostasis;Human;Incidence;inducible Cre;innovation;insight;instructor;Intestinal Metaplasia;Intestines;Knock-out;Knowledge;Laboratories;Leadership;Learning;LoxP-flanked allele;Maintenance;Malignant neoplasm of esophagus;Malignant Neoplasms;Manuscripts;Medicine;meetings;Mentors;Mentorship;Metaplasia;Molecular;molecular subtypes;mouse model;Multiomic Data;multiple omics;Mus;new therapeutic target;novel;Oncology;Organoids;overexpression;Patients;Pattern;Phenotype;Physicians;Precancerous Conditions;premalignant;Preparation;prevent;Primitive foregut structure;Process;programs;Proteins;proteogenomics;Proteomics;Publications;Regulation;Repression;Research;research and development;response;restoration;Risk Factors;Role;Scientist;Series;skills;Squamous Cell;Squamous Epithelium;Stomach;Technical Expertise;Techniques;Testing;Time;Tissues;tool;Training;trait;transcription factor;transcriptomics;tumorigenesis;Variant;Work

PROJECT_TITLE: The Role of SOX2 and CDX2 in Barrett's Esophagus Development

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Methamphetamine;Prevention;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

ORG_STATE: MA

PHR: PUBLIC HEALTH RELEVANCE (NARRATIVE) Methamphetamine (MA) use is increasing rapidly in the United States and disproportionately impacts cisgender men who have sex with men (MSM), contributing to high HIV risk in this group. To successfully reduce HIV rates in the US, it is critical to effectively engage MSM who use MA in pre-exposure prophylaxis (PrEP) programs; however, MA is associated with suboptimal adherence to daily, oral PrEP. Therefore, this proposal seeks to assess the level and correlates of interest in different LA PrEP formulations, and facilitators, barriers, and preferences for delivery of long acting cabotegravir (CAB LA) PrEP among MSM who use MA.

PI_NAMEs: MCMAHAN, VANESSA  (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Adherence;AIDS prevention;Appointment;Behavioral;cis-male;cisgender;Cities;Code;cognitive interview;condomless anal sex;Data;Data Collection;Development;Effectiveness;Ensure;Equity;Evaluation;experience;experimental study;follow-up;forgetting;Formulation;Frequencies;Future;health disparity;Heterogeneity;high risk;HIV;HIV Infections;HIV risk;HIV Seronegativity;Hour;Housing;Implant;Incentives;Inequity;informant;Injections;interest;Intervention;Interview;Location;medication compliance;men who have sex with men;Methamphetamine;methamphetamine use;Modality;Modeling;Morbidity - disease rate;mortality;novel;Oral;Participant;Patient Recruitments;Patients;Phase;Population;pre-exposure prophylaxis;preference;Prevalence;prevent;Prevention strategy;programs;Provider;public health relevance;Reporting;Research;Risk;Sampling;San Francisco;service providers;Services;Site;social stigma;Source;statistics;subcutaneous;Subgroup;Surveys;System;therapy development;Time;transgender women;truvada;United States;uptake;Work

PROJECT_TITLE: Tailoring Delivery of LongActing PrEP for Cisgender (MSM) who Use Methamphetamine

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MADISON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE As the most common genetic developmental disorder that leads to intellectual disability, Down syndrome is a public health concern. The proposed research will better define the developmental defects that occur during formation of the human brain in Down syndrome. The results will provide insight into the biological bases of intellectual and developmental disabilities and could potentially lead to the design of therapeutic interventions.

PI_NAMEs: BHATTACHARYYA, ANITA  (contact);ZHANG, SU-CHUN

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Anatomy;Atlases;base;Biological;Brain;cell type;Cells;Chromosome 21;Cognition;Cognitive;Complex;Defect;Dendritic Spines;design;Development;developmental disease;developmental genetics;Developmental Process;Disease;Down's Syndrome;Ensure;excitatory neuron;Exhibits;experimental study;frontal lobe;Functional disorder;Future;gamma-Aminobutyric Acid;gene regulatory network;Genes;Genetic;Genetic Transcription;Glutamates;Hippocampus;Human;Human Chromosomes;Human Genetics;human induced pluripotent stem cells;Impaired cognition;Impairment;in vitro Model;in vivo;Individual;induced pluripotent stem cell;inhibitory neuron;insight;Intellectual functioning disability;Interneurons;Intervention;Long-Term Potentiation;Mental Depression;model building;Modeling;Molecular;Molecular Profiling;Motor;mouse development;mouse model;Mus;neurodevelopment;neurogenesis;neuron development;Neuronal Differentiation;Neuronal Dysfunction;neuronal excitability;Neuronal Plasticity;Neurons;Pathway interactions;pluripotent stem cell differentiation;Population;postnatal;Pregnancy;prenatal;Process;progenitor;programs;Public Health;Research;Resources;Sampling;Signal Transduction;social;Specific qualifier value;stem cell model;Synapses;Synaptic plasticity;Synaptic Transmission;synaptogenesis;Temporal Lobe;Therapeutic Intervention;three dimensional cell culture;Transcriptional Regulation;Work

PROJECT_TITLE: Human cortical development and neural plasticity altered by trisomy 21

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-W(55)]


NIH_SPENDING_CATS: Brain Disorders;Dental, Oral, and Craniofacial Disease;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Down syndrome (DS) is associated with atypical tongue movement that contributes to devastating challenges with communication and feeding, but the biological mechanisms underlying these challenges are not known. This research will investigate early postnatal changes in tongue muscles and brainstem in a mouse model of DS at three different timepoints during oromotor development, as well as after two different oromotor activity conditions.

PI_NAMEs: GLASS, TIFFANY  (contact)

PROJECT_TERMS: Affect;Age;Anatomy;Apnea;Awareness;Basic Science;Behavioral;Behavioral Assay;Biological;Biological Markers;Biological Models;Biology;Birth;Brain Stem;Breathing;Cephalic;Characteristics;Child;Childhood;Clinical;Communication;Complex;Data;Deglutition;Deglutition Disorders;Development;Developmental Delay Disorders;Developmental Disabilities;developmental disease;Developmental Process;Disease;Down's Syndrome;drinking;early childhood;Eating;Evaluation;Failure;feeding;Foundations;Future;Gene Expression;Gene Expression Profiling;Goals;Health;Human;Hydration status;hypoglossal nucleus;Immunofluorescence Immunologic;Impairment;Individual;Individuals with physical disabilities;Intellectual functioning disability;Intervention;Knowledge;Liquid substance;Measures;Microanatomy;model organism;Modification;mortality risk;Motor;Motor Skills;mouse model;mouse Ts65Dn;Movement;Mus;Muscle;muscular system;National Institute of Child Health and Human Development;Neonatal;neuromuscular;neuromuscular system;novel therapeutic intervention;nutrition;Outcome;Peripheral;Phenotype;postnatal;postnatal development;Quality of life;rational design;Reporting;Research;Resolution;response;Science;Siblings;Speech;Speech Intelligibility;Structure;System;targeted treatment;Texture;therapeutic evaluation;therapeutic target;therapy development;Time;Tongue;tool;translational model;United States National Institutes of Health;Weaning;Work

PROJECT_TITLE: Tongue maturation deficits in a mouse model of Down syndrome

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The ECHO Cohort Study is an extensive resource for elucidating the roles of environmental and genetic characteristics that affect child health. The JHU/RTI Data Analysis Center will advance ECHO research by providing state-of-the-art systems for data collection and management, innovative, unbiased analyses, and by publicizing high quality, well-documented ECHO data to promote informative analyses by the scientific community at-large.

PI_NAMEs: CATELLIER, DIANE J;JACOBSON, LISA P (contact)

PROGRAM_OFFICER_NAME: PARK, CHRISTINA H

PROJECT_TERMS: Acceleration;Accountability;Address;Adoption;adverse outcome;Affect;analytical method;Attention;Biometry;Characteristics;Child Development;Child Health;Childhood;cohort;Cohort Studies;Collaborations;Collection;Communication;Communities;Complex;Data;Data Analyses;Data Collection;data ecosystem;data framework;data integration;data management;data quality;Data Science;data sharing;data standards;database structure;Dedications;design;Development;Disparate;Ensure;Environment;Environmental Exposure;Environmental Health;Epidemiology;epidemiology study;Epigenetic Process;equity, diversity, and inclusion;experience;FAIR principles;Familiarity;Family;flexibility;Fostering;Generations;Genetic;Genetic Predisposition to Disease;Geography;Health;Individual;Informatics;Information Systems;Infrastructure;innovation;Institution;International;Investigation;Knowledge;Leadership;Life Cycle Stages;Link;longitudinal analysis;Measures;Metadata;method development;Methodology;Methods;Mission;multilevel analysis;next generation;novel;Outcome;Outcomes Research;Participant;Pediatric Research;Philosophy;Population;Principal Investigator;Productivity;programs;Protocols documentation;Publications;Reporting;Reproducibility;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Proposals;Resources;Role;Science;Scientist;Secure;Site;social;Specific qualifier value;statistics;Structure;success;support tools;Surveys;synergism;System;tool;tool development;Translating;United States National Institutes of Health;Universities;Visualization

PROJECT_TITLE: ECHO DAC (Environmental Influences on Child Health Outcomes Data Analysis Center)


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Eye Disease and Disorders of Vision;Patient Safety;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: Chicago

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative We have already started a single-center, clinical trial titled “MSC Secretome Study”, to assess the safety of allogeneic bone marrow-derived MSC secreted factors on the ocular surface, and also obtain a preliminary observation on 1) epithelial healing; 2) development of scarring; and, 3) final visual acuity; with the objective of improving clinical outcomes in significant non-healing corneal epithelial disease. Phase 1 is a dose escalation safety study (Specific Aim #1) and Phase 2a is to further establish safety and assess preliminary evidence of efficacy (Specific Aim#2).

PI_NAMEs: DJALILIAN, ALI R (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Administrative Supplement;Affect;Allogenic;Autoimmune Diseases;Award;Back;Blindness;Bone Marrow;Cell secretion;Chemical Injury;Chronic;Cicatrix;Clinical;Clinical Trials;Controlled Study;Cornea;Corneal Diseases;corneal epithelium;corneal regeneration;corneal repair;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;cryogenics;Data;data quality;design;Development;Diabetes Mellitus;Disease;Dose;epithelial stem cell;Epithelium;extracellular vesicles;Eye;Eyedrops;Fibrosis;Funding;Goals;healing;Hospitals;Human Resources;Illinois;Immune;Impairment;improved;Inflammation;innovation;Institution;Institutional Review Boards;Laboratories;Letters;limbal;manufacture;manufacturing process;Masks;Maximum Tolerated Dose;Mediating;melting;Mesenchymal;mesenchymal stromal cell;Modification;Monitor;ocular surface;Outcome;pandemic disease;participant enrollment;participant safety;Pathologic;Patient Recruitments;patient subsets;Patients;Performance;Pharmacy facility;Phase;phase 1 study;prevent;programs;Protocols documentation;Quality Control;Reagent;Recommendation;recruit;Regenerative Medicine;Regulation;Research Project Grants;response;Safety;safety assessment;safety study;stem;stem cell therapy;stem cells;Stromal Cells;supply chain;tissue regeneration;tissue repair;Tissues;Ulcer;Universities;Vial device;Visual Acuity;Visual disability

PROJECT_TITLE: Phase I Study of Mesenchymal Stromal Cell Secretome for Promoting Corneal Regeneration


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Regenerative Medicine

ORG_CITY: Fort Lauderdale-Davie

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NOVA SOUTHEASTERN UNIVERSITY

ORG_STATE: FL

PHR: Project narrative: One out of every two American adults aged 30 and over has periodontitis, which is an inflammatory bone lytic disease caused by poly-microbial infection around tooth. It is well documented that bone regeneration hardly ever occurs at the alveolar bone affected by periodontitis, even after the successful conventional periodontal treatment. Based on our preliminarily discovered finding, i.e., OC-STAMP molecule that specifically expressed by osteoclasts (bone resorbing cells) is engaged in not only bone resorption but also interruption of new bone regeneration, in the proposed RO1 project, we will gain more scientific insight into this finding for the development of novel non-invasive bone regenerative therapy for periodontitis and other bone lytic disease.

PI_NAMEs: KAWAI, TOSHIHISA  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Accounting;Activated Lymphocyte;Adult;Affect;Age;aged;alveolar bone;Alveolar Bone Loss;American;Anti-citrullinated peptide antibody;Bacteria;bone;bone loss;Bone Matrix;Bone Regeneration;Bone remodeling;Bone Resorption;CD100 antigen;Cell membrane;Cells;Characteristics;citrullinated protein;Coculture Techniques;Coupling;Defect;demineralization;Dendritic Cells;Development;Disease;Event;Excision;functional genomics;gain of function;Generations;Goals;Histocytochemistry;In Vitro;in vivo;in vivo imaging;Infection;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;Injections;insight;Integral Membrane Protein;Interruption;Knockout Mice;Ligand Binding;Ligands;Ligature;loss of function;Lytic;Mediating;Membrane;Messenger RNA;Molecular;Monoclonal Antibodies;monocyte;mouse model;multimodality;Mus;new therapeutic target;NIH 3T3 Cells;novel;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteogenesis;osteogenic;osteoimmunology;overexpression;pathogen;Pathogenicity;Pathologic;Periodontitis;periodontopathogen;Persuasive Communication;Phenotype;Phosphorylation;Population;Porphyromonas gingivalis;Production;protein activation;Protein-arginine deiminase;Proteins;Publishing;receptor;regenerative therapy;release factor;Reporting;response;Role;Scientist;Signal Transduction;Site;skeletal;Small Interfering RNA;Somatomedins;Structure-Activity Relationship;Testing;Time;TNFSF11 gene;Tooth structure;transcriptome;transcriptome sequencing;Up-Regulation;vector;Vimentin

PROJECT_TITLE: Osteoimmunology of Retarded Bone Regeneration in Periodontitis


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: Columbus

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative Visceral Leishmaniasis (VL), caused by Leishmania infantum in the Mediterranean basin and imported from there into both South and North America, continues to be a fatal disease if cases are not detected and treated. Dogs are predominant reservoir hosts for visceralizing Leishmania spp. In this proposed work we will use this critical model system to understand how inflammation from this dermotrophic protozoan alters responses to sand fly saliva and whether it can be treated via immunotherapy.

PI_NAMEs: PETERSEN, CHRISTINE A (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Animal Model;Antigens;Arthropods;B-Lymphocytes;Biological Models;Bite;Canis familiaris;CD8-Positive T-Lymphocytes;Cells;Cessation of life;Clinical;cohort;Complex;Data;Dermal;Dermis;Disease;Environment;Epidemiology;Erythrocytes;Event;exhaust;experimental study;Exposure to;feeding;Female;heme oxygenase-1;Hour;Human;Immune;Immune response;Immunity;immunoregulation;Immunotherapy;Infection;Infection Control;Inflammation;Inflammatory;innovation;Integration Host Factors;Intervention;Intervention Studies;Laboratories;Lead;Leishmania;Leishmania donovani;Leishmania infantum;Leishmaniasis;Ligands;Lutzomyia genus;Macrophage;Mediating;North America;Organ;Outcome;Parasitemia;Parasites;Phlebotominae;Phlebotomus;prevent;Productivity;programmed cell death ligand 1;programmed cell death protein 1;Property;Public Health;response;Rupture;Saliva;Salivary;Salivary Proteins;Site;Skin;skin biopsy;South America;Time;transcriptome;transmission process;Trauma;vector;Visceral Leishmaniasis;Work;Zoonoses

PROJECT_TITLE: Alteration of skin immune environment by sand fly saliva across progressive Leishmaniasis

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative  A therapeutic strategy to induce neovascularization of tissues and biomaterials would represent a major breakthrough in the treatment of ischemic tissue disorders, dysfunctional wound healing, and the replacement of damaged tissues. The proposed studies are designed to improve our understanding of how the body naturally orchestrates successful blood vessel growth, and then to apply these principles to the design of novel biomaterials that harness these processes to promote vascularization.

PI_NAMEs: SPILLER, KARA LORRAINE (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: angiogenesis;Atherosclerosis;Autoimmune Diseases;Behavior;Biocompatible Materials;Blood Vessels;Brain Ischemia;cancer therapy;Cell secretion;Cell Therapy;chronic wound;Complex;Cues;Data;design;Diabetes Mellitus;directed differentiation;Disease;efficacy testing;Endothelial Cells;Exhibits;Expression Profiling;Functional disorder;Gene Expression;Goals;Growth;healing;Heart;Hindlimb;Human;immunoregulation;Impaired healing;Impairment;improved;In Vitro;in vivo;Inflammatory;Inflammatory Response;Interleukin 4 Receptor;Interleukin-4;Ischemia;Kinetics;Leukocyte Trafficking;Macrophage;Mediating;Mediator;migration;mimicry;Modeling;monocyte;mouse model;Mus;Myocardial Ischemia;neovascularization;novel;novel strategies;particle;Pathologic Neovascularization;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Phenotype;Population;Process;protein expression;receptor;recruit;regeneration function;regenerative;Regulation;Regulatory T-Lymphocyte;response;response to injury;revascularization;Signal Transduction;Stimulus;Supporting Cell;Testing;Therapeutic;Time;Tissue Engineering;Tissues;Vascularization;Work;wound healing

PROJECT_TITLE: Understanding and Controlling Macrophage Behavior in Angiogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-V(02)M]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

ORG_STATE: CA

PHR: NARRATIVE Black sexual minority men (BSMM), who comprise a substantial proportion of people with HIV, are affected by large health disparities for multiple mental and physical health indicators that increase with age, and also show high levels of social disconnectedness (loneliness and social isolation). This application proposes to use a community engaged longitudinal mixed methods social network study to examine how changes in loneliness and social isolation are related to changes in health and wellness among aging BSMM, and how multileveled social-ecological contextual factors may explain, buffer, or amplify impacts of social disconnection on health.

PI_NAMEs: BOGART, LAURA M (contact);GREEN, HAROLD D.

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Affect;Age;age acceleration;age effect;aged;Ageism;Aging;Alabama;American;Area;Attention;Behavioral Model;black men;Black race;Buffers;California;Cessation of life;Characteristics;Chronic;Clinical Trials;Communities;community based participatory research;community engagement;Community Networks;contextual factors;coping;Data;Discrimination;Disease;Disparity;disparity reduction;Drops;Epidemic;experience;Fostering;Future;gender minority health;General Population;Health;Health behavior;health difference;health disparity;Health Promotion;Health Services Accessibility;Healthcare;healthy aging;HIV;HIV Seropositivity;Home;human old age (65+);Immune System Diseases;Individual;innovation;instrument;Intervention;Interview;Learning;life span;Link;Loneliness;Longevity;male;Measures;Mediating;Mediator;member;men;Mental Health;Methods;mortality;Neighborhoods;novel;older adult;Outcome;Participant;Persons;physical conditioning;Physiological;Politics;poor health outcome;Population;premature;Prevention;Quality of life;racial minority;recruit;Reporting;Research;resilience;resilience factor;response;Risk Factors;sex;Sexual and Gender Minorities;sexual minority;sexual minority men;social;social health determinants;Social isolation;Social Network;social network intervention;social stigma;social vulnerability;socioeconomics;Strategic Planning;Subgroup;Surgeon;Surveys;System;Testing;theories;therapy development;Time;United States National Institutes of Health;Viral Load result;Virus;Work

PROJECT_TITLE: Social Connectedness, Loneliness, and Health Among Aging Black Sexual Minority Men

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Narrative The duration and nature of immune response to SARS-CoV-2 (CoV2) infection, especially in asymptomatic individuals, needs better understanding. This supplement continues the overall objectives of the original proposal to follow household contacts with clinical cases of CoV2 to determine immune events associated with early viral exposure. The study will evaluate innate and adaptive immune responses and their correlation with viral clearance and the development of effective immunity and long-term memory. The research will also examine the relationship between early immune response and long-term immunity, and develop serological tests based on these findings.

PI_NAMEs: KING, CHRISTOPHER L (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Address;Antibodies;Antibody Response;Blood;Blood Cells;Cells;Clinical;Development;Evaluation;Event;Failure;Grant;Household;Humoral Immunities;Immune;Immune response;Immunity;Immunoglobulin A;Immunoglobulin G;Immunologic Memory;Individual;Innate Immune Response;Knowledge;long term memory;Longitudinal cohort;Nature;Nursing Homes;Onset of illness;Oral;Patients;prospective;Proteins;Proteomics;Research;response;RNA vaccine;Saliva;Sampling;SARS-CoV-2 antigen;SARS-CoV-2 infection;Serology test;Site;Transcend;transcriptome sequencing;Variant;variants of concern;Viral;Viral load measurement

PROJECT_TITLE: Early Drivers of Humoral Immunity to SARS-CoV-2 Infections


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROGRAM NARRATIVE This training is specifically designed to prepare a new cadre of researchers to address significant health disparities among sexual and gender minority (SGM) populations in India. Selected participants will gain an understanding of local SGM health concerns, strengthen SGM health research skills, and enrich their professional development. This program will enhance diverse perspectives in the Indian health research workforce by increasing the number of skilled scientists to conduct SGM health research in order to ultimately contribute to reduction in SGM health inequities in India.

PI_NAMEs: BARRY, MICHELE ;HARRIS, EVA ;KO, ALBERT ICKSANG (contact);MADHIVANAN, PURNIMA

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TERMS: Address;Africa;Arizona;Asia;California;career;Career Choice;career development;Caribbean region;Central America;Collaborations;Communicable Diseases;Communities;Country;Dedications;design;Discipline;Disease;doctoral student;Eastern Europe;Educational workshop;Environmental Health;Exposure to;Faculty;faculty mentor;gender minority health research;global health;Health;health equity;Health equity research;HIV;Human;India;Inequity;Injury;Institution;Interpersonal Violence;low and middle-income countries;member;Mental Health;Mentors;Mentorship;Methods;multidisciplinary;Persons;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Methodology;Research Personnel;Research Support;Research Training;Rural;Scholars Program;Sexual and Gender Minorities;Site;Slum;South America;Substance abuse problem;Supervision;Time;Training;Training Programs;Universities;Vulnerable Populations;Women's Health;Work

PROJECT_TITLE: Global Health Emerging Scholars Program

SUFFIX: SE


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Data Science;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE Populations forcibly displaced due to conflict or natural disasters are at increased risk of numerous acute and chronic health hazards and humanitarian settings such as refugee camps pose grave threat to public health not only for the forcibly displaced persons but to host communities as well. To address well-documented research capacity gap, we propose employing a three-phased participatory approach involving key stakeholders including UNHCR, IRC, Office of the Prime Minister (OPM) that is responsible for refugee welfare in Uganda, and refugees to identify research capacity gaps and develop a much-needed research training curriculum focused on intervention research design, implementation, and ethical conduct of research and recruit 30 refugee youth to receive a 12-week structured research capacity building training. By developing and extending this research training opportunity to refugee youth who do not otherwise have access to such opportunities, this proposal is aligned with objectives of FIC’s initiative to promote diverse perspectives in its training and educational programs.

PI_NAMEs: NABUNYA, PROSCOVIA ;NASEH, MITRA ;SSEWAMALA, FRED M (contact);TUTLAM, NHIAL TIMOTHY

PROJECT_TERMS: Acute;Address;Administrative Supplement;adolescent health;Age Years;Anxiety;Area;Bachelor's Degree;Child Health;Chronic;Communicable Diseases;Communities;comorbidity;Conflict (Psychology);cultural competence;Data;Data Science;Disease;Educational Curriculum;Ethics;Evaluation;evidence base;Guidelines;Health;health disparity;Health Hazards;High Prevalence;implementation science;Informed Consent;interest;Intervention Studies;Knowledge;Language;Malnutrition;meetings;Mental association;Mental Depression;Mental disorders;Mental Health;mortality;parent grant;Participant;Phase;Population;Post-Traumatic Stress Disorders;Program Evaluation;Public Health;recruit;Refugee Camp;Refugees;Research;Research Design;Research Personnel;Research Training;Resource-limited setting;Structure;Training;Training Programs;Trauma;Uganda;UNHCR;Vulnerable Populations;welfare;Youth

PROJECT_TITLE: Addressing the Research Capacity Gap in Global Child, Adolescent, & Family Health Utilizing Implementation and Data Sciences


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative: Persons living with HIV face a higher than expected risk of cardiovascular disease for unknown reasons. This proposal will help to identify mechanisms that are associated with this increased risk which can identify novel interventions to reduce CV risk as well as have a beneficial impact on HIV disease and other comorbidities.

PI_NAMEs: CHI, NEIL C;FREIBERG, MATTHEW S;HSUE, PRISCILLA Y. (contact);NATARAJAN, PRADEEP

PROGRAM_OFFICER_NAME: PATHAK, ELIZABETH BARNETT

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adaptive immunity;adjudication;adverse outcome;Age;aged;Aging;antiretroviral therapy;Atherosclerosis;Biological Assay;Biological Markers;biomarker evaluation;Blood Cells;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;cell type;Cells;Chromosome abnormality;Chronic;Chronic Disease;Clinic Visits;Clinical;Clonal Expansion;cohort;Cohort Studies;Communicable Diseases;comorbidity;cost effective;Data;Department of Defense;Development;Disease;DNMT3a;driver mutation;Epigenetic Process;epigenomics;Ethnic Origin;Evaluation;Event;Face;Gender;gene regulatory network;General Population;Genes;genome wide association study;Hematopoiesis;Hematopoietic;High Prevalence;HIV;HIV Infections;human old age (65+);Immune;immune activation;immune function;immunomodulatory therapies;Individual;Infection;Inflammation;Inflammatory;inflammatory marker;Interleukin-1 beta;Interleukin-6;Intervention;JAK2 gene;Longitudinal cohort;Lymphoid;Lymphoid Cell;Malignant Neoplasms;Measures;mortality;mosaic;multiple omics;Mutation;Myelogenous;Myeloid Cells;Natural Immunity;novel;novel marker;Older Population;Outcome;Pathologic;Pathway interactions;Persons;Placebos;Play;Population;premature;programs;prospective;Research;Risk;Risk Factors;Role;Smoking;System;systemic inflammatory response;Veterans;Viral;Viral Load result;Viral reservoir;Work

PROJECT_TITLE: Evaluation of Novel Clonal Hematopoiesis Of InDEterminate Potential, Mosaic Chromosomal Alterations and CardioVascular Disease in HIV Infection (ENCODE CVD in HIV)

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention;Rehabilitation

ORG_CITY: BIRMINGHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because dementia is rapidly increasing in prevalence and is the most expensive medical condition in the US. We will implement an adaptive clinical trial to examine which cognitive training techniques enhance older adults' everyday function and successfully delay dementia onset. Thus, the proposed research is relevant to NIH's mission to enhance health, lengthen life, and reduce illness and disability.

PI_NAMEs: EDWARDS, JERRI  (contact)

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: active control;Address;Adoption;Affect;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Amyloid beta-Protein;arm;Attenuated;Award;Behavior;Biological Markers;Blood;blood-based biomarker;Brain;cerebral microbleeds;Cerebrum;clinical diagnosis;clinical practice;Clinical Trials;Clinical Trials Design;Cognition;Cognitive;cognitive benefits;Cognitive deficits;cognitive testing;cognitive training;Communities;computerized;cost;Data;Dementia;dementia risk;design;Diagnosis;disability;Disease;executive function;Exercise;expectation;follow-up;functional gain;functional improvement;Goals;Grant;Health;high risk;Hippocampus;improved;Incidence;indexing;Individual;innovation;instrumental activity of daily living;International;Intervention;Investigation;Knowledge;Life;Light;Measures;Medical;Methodology;mild cognitive impairment;Mind;Minority Recruitment;Mission;Morbidity - disease rate;neurofilament;neuroimaging;Neuropsychology;Nonpharmacologic Therapy;novel;older adult;Outcome;Participant;Performance;Perfusion;Persons;Phase;phase II trial;phase III trial;Play;Prevalence;Prevention;preventive intervention;Probability;processing speed;prospective;Protocols documentation;Public Health;Randomized;randomized trial;randomized, clinical trials;Recommendation;recruit;Research;Research Personnel;Rest;Risk;Role;Structure;sustained attention;tau-1;Training;Training Technics;trial comparing;trial design;trial planning;United States National Institutes of Health;white matter;White Matter Hyperintensity;Work

PROJECT_TITLE: ACTIVE MIND: An adaptive clinical trial of cognitive training to improve function and delay dementia


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Natural Products

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: The general goal of this proposal is to support Dr. Ryan Bradley's ability to mentor emerging clinical complementary and integrative health researchers and to advance the field of natural products research. This will be done by allowing Dr. Bradley to gain additional training in mentorship, reduce his administrative responsibilities to allow focus on mentorship, and work with trainees to generate new results and publications from recently completed clinical research toward new grant applications. From a practical perspective this proposal will lead to more qualified CIH clinical researchers and improved clinical trials of natural products.

PI_NAMEs: BRADLEY, RYAN D (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: Administrative Supplement;Adult;Applications Grants;Appointment;Award;Awareness;Biological;Biological Markers;career;career development;Clinical;clinical care;clinical epidemiology;Clinical Research;Clinical Trials;cohort;Collaborations;Collection;Competence;Complementary Health;Critical Pathways;Data;Dedications;Doctor of Philosophy;Environment;Epidemiologist;equity, diversity, and inclusion;experience;Exposure to;Funding;Future;Future Generations;Goals;graduate student;Health;improved;Industry;Integrative Medicine;interest;International;Investments;K-Series Research Career Programs;Laboratories;Measurement;Mediator;Medical Research;Medicine;Mentors;Mentorship;Methodology;Methods;mid-career faculty;National Center for Complementary and Integrative Health;Natural Products;Oregon;Pacific Northwest;Pharmacy Schools;Phase I Clinical Trials;Phase II Clinical Trials;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;programs;Publications;Qualifying;Request for Proposals;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;response;Safety;Sampling;Science;Scientist;skills;Structure;Training;Training Activity;Training Programs;transcription factor;translational physician;Translational Research;translational scientist;United States;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: Mentorship in Clinical Complementary and Integrative Health Research


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Hematology;Human Genome;Pediatric;Prevention;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Defects in the ribosome, the cellular machine that translates genetic instructions into proteins, cause diseases and cancer. Exploring how ribosome defects affect a simple organism, the fruitfly, and using genetic methods to understand the mechanisms, will suggest ways to treat and prevent human disease.

PI_NAMEs: BAKER, NICHOLAS E (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 5' Untranslated Regions;Affect;Alleles;Anemia;Antioxidants;Autophagocytosis;Biogenesis;Bioinformatics;biological adaptation to stress;Biological Assay;bZIP Domain;Cancer Etiology;cancer predisposition;Cell division;Cell Physiology;Cells;CRISPR/Cas technology;Cultured Cells;Cytoprotection;Defect;deletion analysis;Development;Diamond-Blackfan anemia;Disease;DNA Binding Domain;DNA Transposable Elements;Drosophila genus;early onset;fitness;fly;Gene Modified;Gene Proteins;Genes;Genetic;Genetic Transcription;Genome;Genomic Instability;Genotype;Growth;Growth and Development function;Health Promotion;Heterozygote;Human;human disease;Impairment;Individual;Instruction;Loss of Heterozygosity;Luciferases;Malignant Neoplasms;Mammals;Maps;Mediating;Messenger RNA;Methods;Molecular;Morphology;mRNA sequencing;mRNA Stability;multicatalytic endopeptidase complex;mutant;Mutate;Mutation;Organism;Oxidative Stress;Pathway interactions;Peptide Initiation Factors;Phenotype;Phosphorylation;Physiological;Play;prevent;programs;Protein Biosynthesis;Protein Isoforms;Proteins;Reaction;Regulation;Reporter;response;Ribosomal Proteins;ribosome profiling;Ribosomes;ribosomopathy;Role;sensor;Tertiary Protein Structure;Tissues;TP53 gene;transcription factor;Transcriptional Regulation;Transgenes;Translating;Translational Repression;Translations;ubiquitin-protein ligase

PROJECT_TITLE: Ribosomes and growth regulation

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Prevention

PHR: Project Narrative: Persons living with HIV have a significantly increased risk of cardiovascular disease and mortality which may be due to traditional risk factors and chronic inflammation in the setting of treated HIV. Bempedoic acid lowers both cholesterol and inflammation. The purpose of this study is to evaluate the biology of bempedoic acid on atherosclerosis among individuals with treated and suppressed HIV infection.

PI_NAMEs: DURSTENFELD, MATTHEW ;HSUE, PRISCILLA Y. (contact);TAWAKOL, AHMED A

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Accounting;Acids;Adipose tissue;aged;Anti-Inflammatory Agents;Anti-Retroviral Agents;antiretroviral therapy;Apolipoproteins B;Atherosclerosis;atorvastatin;ATP Citrate (pro-S)-Lyase;B-Lymphocytes;Biological Markers;Biology;Blood Component Removal;burden of illness;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Carotid Artery Plaques;Cessation of life;Cholesterol;Chronic;Clinical;Coagulation Process;cohort;Collaborations;Core Facility;Coronary artery;coronary computed tomography angiography;coronary plaque;Data;Diabetes Mellitus;disability-adjusted life years;Disease;Enrollment;Event;Evolution;Familial Hypercholesterolemia;FDA approved;Fibrin fragment D;fluorodeoxyglucose positron emission tomography;follow-up;Future;General Hospitals;General Population;Glycosylated hemoglobin A;Hematopoietic;hematopoietic tissue;Heterozygote;High Density Lipoproteins;high risk;HIV;HIV Infections;imaging facilities;immune activation;Immune response;improved;indexing;Individual;Infiltration;Inflammation;Inflammatory;inflammatory marker;inhibitor;Interleukin-6;Intervention;Intervention Studies;Lipid-Laden Macrophage;Lipids;Low-Density Lipoproteins;Macrophage;Massachusetts;Measures;monocyte;mortality;Multicenter Trials;multidisciplinary;Myocardial Infarction;novel therapeutics;Obesity;Outcome;Outcome Study;Participant;Patients;Persons;PET/CT scan;Pharmaceutical Preparations;Placebos;Population;Positron-Emission Tomography;Prediabetes syndrome;Process;protective effect;randomized placebo controlled study;recruit;Regimen;Reporting;Resources;Risk;Risk Factors;Safety;systemic inflammatory response;T-Lymphocyte;Therapeutic;Tissues;Translating;Triglycerides;Universities;Utah

PROJECT_TITLE: Cholesterol and inflammation Lowering via BEmpedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

PHR: The overarching goal of the “Partnership for Advancing Cervical Cancer Prevention in Women Living with HIV” is to improve the cascade of cervical cancer prevention for women living with HIV (WLWH) including increasing uptake of cervical cancer screening services, improving management of screen positive women, and optimizing precancer treatment outcomes, particularly in resource-constrained settings. Partnership members have established collaborations with a history of conducting successful clinical trials and impacting clinical care. As a CASCADE Research Base, we will provide impactful scientific and statistical direction for pragmatic clinical trials to be conducted at the CASCADE Clinical Sites.

PI_NAMEs: CHIBWESHA, CARLA J;GIULIANO, ANNA R.;WILKIN, TIMOTHY J. (contact)

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Adherence;Adoption;Affect;Aftercare;AIDS clinical trial group;AIDS Malignancy Consortium;antiretroviral therapy;Area;automated visual evaluation;base;Cancer Prevention Trial;career;career development;Cervical;cervical cancer prevention;Cervical Cancer Screening;Characteristics;Clinic;Clinical;clinical care;Clinical Research;clinical research site;Clinical Trials;Cold Therapy;Collaborations;Colposcopy;Communication;community engagement;Consolidated Framework for Implementation Research;cost;Data;Decision Making;design;Detection;Development;Division of Cancer Prevention;Effectiveness;effectiveness evaluation;effectiveness outcome;experience;Fluorouracil;Fostering;Frequencies;Future;Goals;HIV;HPV screening;HPV-High Risk;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation evaluation;implementation outcomes;implementation science;improved;improved outcome;Individual;Infrastructure;Institution;International;Intervention;Investigation;Leadership;loop electrosurgical excision procedure;low and middle-income countries;Maintenance;Malignant neoplasm of cervix uteri;member;Mentors;Patients;Performance;Persons;Physicians;point of care;Positioning Attribute;Pragmatic clinical trial;pragmatic trial;premalignant;prevention service;Prevention trial;Primary Care;Process;protocol development;randomized, clinical trials;Recording of previous events;repository;Research;Research Personnel;Resource-limited setting;Sampling;scale up;screening;screening services;Sensitivity and Specificity;Site;skills;Specimen;Squamous intraepithelial lesion;standard of care;Testing;Treatment outcome;treatment trial;Triage;uptake;Visual;Woman;women's prevention;Work

PROJECT_TITLE: Partnership for advancing cervical cancer prevention in women living with HIV (CASCADE - Research Hub)


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Emergency Care;Health Services;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: ROCKVILLE

ORG_NAME: THE EMMES COMPANY, LLC

PI_NAMEs: MCCORMACK, JENNIFER  (contact)

PROJECT_TERMS: Accident and Emergency department;Buprenorphine;Contracts;Helping to End Addiction Long-term;improved;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;Public Health;Research;Speed;United States National Institutes of Health;Validation

PROJECT_TITLE: EMERGENCY DEPARTMENT-INITIATED BUPRENORPHINE AND VALIDATION NETWORK TRIAL (CTN-0099). 08/15/2023 - 10/18/2024. N01DA-22-2253. TASK ORDER 75N95023F00007 (TO11).


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Eating disorders (EDs) are pernicious conditions with the highest mortality rate of any psychiatric disorder. Gaps in our knowledge regarding the prevalence of EDs in male and female Veterans, what healthcare services are being used by Veterans with EDs and what services Veterans with EDs would like to use if offered in the VA, the impact of military sexual trauma and combat exposure on the development of EDs, validity of ED screening measures, and Veteran preferences for screening limit VA's ability to respond to the needs of Veterans with EDs. EDs disproportionately affect women, and female Veterans are the fastest growing segment of Veterans Health Administration (VHA), underscoring the need for examination of EDs and gender similarities/differences. Our findings will provide important information regarding the scope of the problem of EDs and inform approaches for targeted screening within VA. This proposal addresses an important gap in caring for Veterans with EDs. Findings will be highly relevant to VHA clinical leaders and policy makers. !

PI_NAMEs: MITCHELL, KAREN SUZANNE (contact)

PROJECT_TERMS: Address;Affect;Anorexia Nervosa;Anxiety;Area;Binge Eating;Binge eating disorder;Bulimia;Caring;Clinical;cohort;combat;combat trauma;Communities;Comprehensive Health Care;Data;Death Rate;Dedications;Department of Defense;Development;Diagnosis;Disease;Disproportionately impacts women;Eating Disorders;Equation;Ethnic Origin;experience;Exposure to;Family;Female;Gender;General Population;Generations;Guidelines;health care service;health care service utilization;Healthcare;Impairment;Individual;individualized medicine;Knowledge;Leadership;male;Measures;Medical;medical appointment;men;Mental Depression;Mental disorders;Methods;Military Personnel;military veteran;Modeling;Newsletter;older adult;older men;Overweight;Participant;Patients;Policy Maker;Post-Traumatic Stress Disorders;preference;Prevalence;Procedures;programs;protective factors;Provider;Psychotic Disorders;Race;Random Allocation;Recommendation;Records;recruit;Reporting;repository;Research;resilience;Resources;Risk;Risk Factors;ROC Curve;Roundup;Sampling;screening;screening program;Sensitivity and Specificity;Services;sexual trauma;statistics;Subgroup;Substance Use Disorder;Surveys;Symptoms;Time;Training;Trauma;trauma exposure;treatment services;Veterans;Veterans Health Administration;Woman;Women's Health;Women's prevalence;Work

PROJECT_TITLE: Eating disorders in Veterans: Risk, resilience, and service use

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Lung;Precision Medicine;Pulmonary Hypertension;Rare Diseases

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative Pulmonary arterial hypertension (PAH) is a highly morbid cardiopulmonary disease characterized by wide differences in biology that underlies inconsistent treatment response. This suggests that PAH is likely to benefit from precision medicine, which aims to link unique molecular features with patient-specific clinical characteristics. In this proposal, we will study a new approach to precision medicine developed by our laboratory that focuses on protein-protein interactions to predict clinical characteristics, outcome, and optimal drug selection in individual PAH patients.

PI_NAMEs: MARON, BRADLEY  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: analytical method;Arterial Disorder;arterial remodeling;Binding;biobank;Biological;Biology;Blood Vessels;Cell Proliferation;Cells;Characteristics;Classification;Clinical;Clinical Management;clinical phenotype;clinical predictors;Clinical Trials;Clinical Trials Design;cohort;Complex;Computer Models;Data;Data Set;Databases;Death Rate;Disease;Distal;Drug Targeting;endophenotype;Family member;Fibrosis;France;Genes;Genetic;Genetic Risk;genetic variant;genome sequencing;Genomics;health related quality of life;healthy volunteer;Heterogeneity;Histologic;Hypertrophy;improved;In Situ;Individual;individual patient;individualized medicine;Inherited;innovation;Laboratories;Link;Lung;Maps;marginalization;Measures;Medicine;Methods;Molecular;Molecular Profiling;novel;novel strategies;Ontology;Outcome;overexpression;Pathogenesis;Pathway interactions;Patients;Pattern;personalized strategies;Pharmaceutical Preparations;Pharmacotherapy;phenome;Phenotype;Plasma;point of care;precision drugs;precision medicine;precision medicine clinical trials;primary pulmonary hypertension;profiles in patients;Prognosis;prognostic;prognostic signature;prognostication;Proliferating;protein expression;protein protein interaction;Proteins;Proteomics;pulmonary arterial hypertension;Pulmonary Heart Disease;Reporting;repository;Resources;response;right ventricular failure;Selection for Treatments;Signal Pathway;Specimen;Testing;therapeutic target;Time;Transcript;treatment response;United Kingdom;Validation;Vascular Diseases;Vascular remodeling;virulence gene;whole genome;Work

PROJECT_TITLE: Personalized protein-protein interactomes and precision medicine in pulmonary arterial hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-G(03)]


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: Criminal justice involvement and recidivism are highly prevalent among Veterans and important social determinants of health. Few treatment options with demonstrated effectiveness are available for Justice- Involved Veterans (JIVs). New comprehensive treatments such as Maintaining Independence and Sobriety Through Systems Integration, Outreach, and Networking-Criminal Justice Edition (MISSION-CJ) are emerging and aim to reduce criminal recidivism, improve treatment access and engagement and address other health- related risk factors underlying recidivism (i.e., substance use, mental health, housing, and employment problems). This study will be run in Mental Health Residential Rehabilitation Treatment Programs, and intends to compare MISSION-CJ versus Enhanced Usual Care, the latter of which includes a structured peer support curriculum as well as community outreach and linkage support. The long-term goal is to help the VA reduce criminal recidivism among JIVs, and improve the long-term health of this vulnerable Veteran population.

PI_NAMEs: BLONIGEN, DANIEL MICHAEL;SMELSON, DAVID A (contact)

PROJECT_TERMS: Acceleration;addiction;Address;Admission activity;Adoption;anti social;antisocial behavior;Attitude;Behavior;behavioral health;Caring;Case Manager;Charge;Chronic;Cognition;Communities;community based care;Community Integration;Community Outreach;community reintegration;Community Services;Continuity of Patient Care;Criminal Justice;Disease;disparity reduction;Education;Educational Curriculum;Effectiveness;effectiveness testing;Elements;Employment;Enrollment;Equipment and supply inventories;Evidence based treatment;follow-up;formative assessment;Future;future implementation;Goals;handbook;Health;health equity;Health Services Accessibility;Homeless persons;Homelessness;Housing;hybrid type 1 design;Hybrids;implementation trial;Imprisonment;improved;Individual;innovation;Intervention;Interview;Justice;Knowledge;Learning;Legal;Legal system;Link;Manuals;Measures;Mediating;Mental Health;Mental Health Court;Mental Health Services;Methodology;military veteran;Mission;Modeling;Monitor;Needs Assessment;novel;Outcome;outreach;peer;peer support;Personal Satisfaction;Population;prevent;programs;Provider;psychosocial;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recidivism;Rehabilitation therapy;Research;Resources;Risk;Risk Assessment;Risk Factors;Running;service delivery;service engagement;service gap;Services;Site;sobriety;social cognition;social health determinants;Specialist;Standardization;Structure;Subgroup;substance use;Substance Use Disorder;Suicide prevention;Supervision;System;Systems Integration;tool;Trauma;treatment as usual;treatment planning;treatment program;Unemployment;Veterans;Work

PROJECT_TITLE: A Randomized Controlled Trial of MISSION-CJ for Justice-Involved Homeless Veterans with Co-Occurring Substance Use and Mental Health

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: LGBT Veterans have faced a long history of stigma, discrimination, and exclusionary policies that were intended to exclude them from military service. Despite recent shifts in policy and increased staff trainings, existing evidence suggests that this group is at high risk for health disparities, particularly with respect to mental health and health risk behaviors. While informative, the research to date has been limited in several respects: cross-sectional designs, collapsing LGBT subgroups, severe lack of data on some subgroups, problems with identifying a comparison group, and lack of data on risk and protective factors and care experiences. This prospective cohort study will fill these gaps, recruiting and conducting surveys online with 1,600 Veterans to identify health disparities, test a conceptual model of prospective risk and protective factors, and assess VA utilization, barriers to care, and treatment preferences. Data from this study will inform future intervention efforts to achieve health equity for LGBT Veterans.

PI_NAMEs: SIMPSON, TRACY L. (contact)

PROJECT_TERMS: Address;Adult;Advertisements;Alcohol consumption;alcohol misuse;American Medical Association;Anxiety;barrier to care;behavioral health intervention;Bisexual;care preference;care systems;Caring;Chronic stress;Clinical Competence;Communities;comparison group;Consultations;Data;Data Collection;design;Discrimination;Disparity;Employee;Equity;Exclusion;experience;Feeling suicidal;Future;Gays;gender difference;Gender Identity;General Population;Geographic Locations;Health;health care service utilization;health disparity;health equity;Healthcare;Heavy Drinking;Heterosexuals;High Prevalence;high risk;Homophobia;improved;Individual;infancy;Institute of Medicine (U.S.);Intervention;Journals;Knowledge;Lesbian;Lesbian Gay Bisexual;Lesbian Gay Bisexual Transgender;LGBT Health;Literature;longitudinal design;Longitudinal Studies;Maps;Measures;member;men;Mental Depression;Mental Health;Methods;Military Personnel;military service;military trauma;military veteran;Minority;Minority Groups;minority stress;minority stressor;Modeling;National Health Interview Survey;Outcome;outreach;Patient Care;peer;Persons;Policies;Population;Post-Traumatic Stress Disorders;preference;Prevention;programs;prospective;Prospective, cohort study;protective factors;Provider;psychological distress;Recording of previous events;recruit;Reporting;Research;Resource Allocation;Risk;Risk Behaviors;Risk Factors;Self Medication;Services;Sex Orientation;sexual identity;Site;Smoking;social networking website;social stigma;Social support;Source;Stigmatization;Strategic Planning;stressor;Subgroup;suicidal risk;Suicide attempt;Surveys;systematic review;Testing;theories;Time;Training;transgender;transgender men;transgender women;transphobia;Veterans;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Understanding Mental Health Problems and Health Risk Behaviors among LGBT Veterans


ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Suicide rates have increased rapidly in Veterans not using VHA care, particularly among females. Yet understanding of the reasons for these increases and how to address them is lacking. To address this knowledge gap, this study compares male and female Veterans who never used VHA care, were lost to VHA care after previous use, and who are currently using VHA care. We will examine if Veterans in these groups differ regarding: (1) circumstances and precipitants to suicide among suicide decedents; (2) mental health care experiences, barriers, and willingness to seek help; and (3) experiences, preferences, and barriers to help-seeking when suicidal. This mixed-methods study will link national datasets for suicide decedents, survey living Veterans, and conduct qualitative interviews of Veterans who have experienced suicidal ideation or suicide attempts. Gender differences will be examined to inform gender-sensitive, patient-centered suicide prevention efforts. Findings will be used to inform suicide prevention efforts for all Veterans, with an emphasis on non-VHA and female Veterans.

PI_NAMEs: HOFFMIRE, CLAIRE ;MONTEITH, LINDSEY LIH (contact)

PROJECT_TERMS: Address;Attention;barrier to care;Caring;Cessation of life;Characteristics;Clinical;clinically actionable;Communities;Data Linkages;Data Set;Distal;empowerment;Enabling Factors;Ensure;Epidemiological trend;evidence base;experience;Feeling suicidal;Female;Gender;gender difference;Health;health care service utilization;Health Services Accessibility;Health Services Administration;Healthcare;help-seeking behavior;Improve Access;improved;innovation;insight;Intervention;Interview;Knowledge;Link;male;Mental Health;Mental Health Services;Methods;Military Personnel;military veteran;Modeling;morphogens;Outcome;patient oriented;Policies;Population;Predisposing Factor;preference;Prevention;Prevention Research;Prevention strategy;Provider;Quality of Care;Recording of previous events;Records;reducing suicide;Reporting;Research;Sampling;Side;sociodemographics;socioeconomics;Source;stressor;Subgroup;suicidal;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Surveys;Target Populations;Testing;trend;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;willingness;Work

PROJECT_TITLE: Preventing Suicide Among Female and Male Veterans Not Receiving VHA Services


ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: High rates of Veteran suicide remain a tragedy. Rates of Veteran suicide have not decreased for 10 years, despite the best efforts of the field. Those interventions that do exist have only modest effects, which are simply insufficient for the magnitude of the problem. This proposal will combine two treatments – brief cognitive behavioral therapy (BCBT) and repetitive transcranial magnetic stimulation (TMS). Both of these interventions can reduce suicide and are available at Veterans Affairs Medical Centers across the country, yet to date no one has combined these therapies. This proposal will test the effect of this combination, and, if successful, will lead to a novel yet implementable new treatment to reduce Veteran suicide.

PI_NAMEs: PHILIP, NOAH STEPHEN;PRIMACK, JENNIFER MARIE (contact)

PROJECT_TERMS: Address;Admission activity;Aftercare;associated symptom;Behavior;Blinded;Brain region;brief intervention;Cessation of life;Clinical;Cognitive Therapy;Combined Modality Therapy;comorbidity;Conduct Clinical Trials;Consultations;cost;Country;Diabetes Mellitus;Diagnosis;Disease;Dissemination and Implementation;Effect Modifiers (Epidemiology);Effectiveness;efficacious treatment;efficacy evaluation;Enrollment;Feeling suicidal;follow-up;Gender;Goals;Growth;Health Priorities;Healthcare Systems;high risk;hospital readmission;Hospitalization;Hospitals;improved;Induced Neurons;innovation;inpatient psychiatric treatment;Inpatients;Intervention;Left;magnetic field;Major Depressive Disorder;Mediating;Mediator;Medical center;Mental Depression;Military Personnel;Modality;Modeling;mortality;novel;operation;optimal treatments;Outcome;Participant;Patients;Pharmaceutical Preparations;Physiologic pulse;Post-Traumatic Stress Disorders;Prefrontal Cortex;programs;psychiatric symptom;psychosocial;Psychotherapy;Randomized;Randomized, Controlled Trials;readmission rates;reduce symptoms;reducing suicide;repetitive transcranial magnetic stimulation;Sampling;secondary analysis;secondary outcome;Severities;side effect;statistics;suicidal;suicidal behavior;suicidal individual;suicidal risk;Suicide;Suicide attempt;suicide attempter;Suicide prevention;suicide rate;System;Techniques;Testing;Time;Transcranial magnetic stimulation;Treatment Efficacy;Treatment outcome;treatment program;United States Department of Veterans Affairs;Veterans;Visit;Weight Gain;Work

PROJECT_TITLE: Combined Transcranial Magnetic Stimulation and Brief Cognitive Therapy to Reduce Veteran Suicide


ORG_CITY: CANANDAIGUA

ORG_NAME: VETERANS AFFAIRS, UNITED STATES DEPARTMENT OF

ORG_STATE: NY

PHR: The risk for suicide increases by nearly 50% in the first year that service members transition from the military to civilian life underscoring the need for effective strategies to facilitate help seeking among Veterans vulnerable to self-directed violence. Yet despite a great need for treatment, more than half of returning Veterans at risk for suicide do not initiate mental health services. VA has embarked on the regular use of communication campaigns as part of a public health approach designed to reach the larger Veteran population with messages promoting help seeking. However, what types of messages effectively change beliefs and behaviors for at-risk Veterans resistant to seek treatment is unclear. The main objective of this study is to develop and test the use of public messaging to increase treatment seeking among Veterans at risk for suicide and resistant to seek mental health care following separation from military service. This represents the first study to systematically develop public messaging strategies for populations at risk for suicide.

PI_NAMEs: KARRAS, ELIZABETH  (contact)

PROJECT_TERMS: 18 year old;2 arm randomized control trial;active duty;Audience Research;Behavior;behavioral response;Belief;Cellular Phone;Communication;Consent;Control Groups;cost;Data;Data Collection;design;Eligibility Determination;evidence base;Evidence based treatment;Exclusion Criteria;experience;Feeling suicidal;follow-up;Funding;Future;Goals;Head;help-seeking behavior;high risk;high risk population;Impairment;improved;inclusion criteria;Individual;innovation;Institutionalization;Intervention;Interview;iterative design;Life;Measures;Mental Health;Mental Health Services;Methodology;Methods;Military Personnel;military service;military veteran;Minority;mobile application;Observational Study;outreach;Ownership;Participant;peer;Performance;Planning Theory;Populations at Risk;portability;Predisposition;prevent;Process;Public Health;Randomized;recruit;repository;Research;Resistance;Risk;Sampling;screening;Self Direction;service member;service utilization;Services;smartphone application;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;Target Populations;Telephone;Testing;treatment services;verbal;Veterans;Violence;Waiting Lists;Woman;Work

PROJECT_TITLE: Public messaging to increase treatment seeking among Veterans at risk for suicide during transition from military service


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: This year, VHA is implementing a new suicidal ideation (SI screening) and evaluation process, VA Risk-ID. However, prior research has shown that Veterans often do not disclose SI at healthcare visits just prior to suicide, and that Veterans frequently feel uncomfortable disclosing SI during screening. The purpose of this project is to is to develop a greater understanding of the impacts of VA Risk-ID screening processes, primarily from the Veterans’ perspective. Up to 2,000 Veterans nationally will complete surveys that assess their satisfaction with screening, patient-care team interactions, and perceived barriers to care and SI disclosure. Up to approximately 40 Veterans and 40 clinical staff members from primary care and mental health settings will participate in qualitative interviews. We will also examine if perceptions of screening and care team actions at the time of screening are related to subsequent engagement of Veterans in mental health treatment. This project will lay groundwork for the development of new approaches and interventions to improve SI screening.

PI_NAMEs: DOBSCHA, STEVEN K (contact)

PROJECT_TERMS: Address;Affect;Afghanistan;anti-depressive agents;barrier to care;Caring;Cessation of life;Characteristics;Clinical;cohort;Collaborations;Data;data warehouse;Detection;Development;Disclosure;Elements;Evaluation;experience;Feeling suicidal;Goals;Health;Health Care Visit;Health Personnel;Healthcare;improved;Individual;innovation;Intervention;Interview;Iraq;Knowledge;Letters;Measures;Medical;Medical Care Team;medical specialties;member;Mental Depression;Mental Health;Mental Health Services;Methodology;Methods;Modeling;Movement;Natural History;novel strategies;Outcome;Pathway interactions;Patient Care Team;patient engagement;patient population;Patient Preferences;Patient-Centered Care;patient-clinician communication;Patients;Perception;Pharmaceutical Preparations;Population;population based;Post-Traumatic Stress Disorders;Primary Care;primary care team;Process;process evaluation;Provider;Recommendation;recruit;reducing suicide;Reporting;Research;research clinical testing;Respondent;response;Risk;Sampling;satisfaction;screening;screening program;Screening Result;Self Direction;Site;Structure;suicidal risk;Suicide;Suicide prevention;Surveys;systematic review;Testing;Therapeutic;treatment optimization;treatment planning;tv watching;Veterans;Veterans Health Administration;Violence;Visit;War

PROJECT_TITLE: Understanding Impact of VHA's New Suicidal Ideation Screening Initiative: Veteran's Perspective


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

PI_NAMEs: GUTIERREZ, ORLANDO M (contact)

PROGRAM_OFFICER_NAME: WONNUM, SUNDANIA J W

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE. Among the many co-occurring conditions that can affect individuals with Down syndrome, the neurological condition known as Down Syndrome Regression Disorder (DSRD) is undoubtedly one of the most detrimental, including symptoms such as catatonia, mutism, depersonalization, loss of ability to perform activities of daily living, hallucinations, delusions, and aggression. This project consists of a research-intensive clinical trial to compare the relative safety and efficacy of three alternative therapeutic approaches in DSRD, including two promising immune-modulatory medicines. Results from this project will produce much needed information about the etiology of DSRD and its response to diverse interventions.

PI_NAMEs: ESPINOSA, JOAQUIN M. (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Activities of Daily Living;Affect;Aggressive behavior;Alzheimer's Disease;Amyloid beta-Protein Precursor;autism spectrum disorder;Autoantibodies;Autoimmune Diseases;Benzodiazepines;Biological Markers;biosignature;Caregivers;Catatonia;cell type;Central Nervous System;Cerebrospinal Fluid;Chromosome 21;circulating biomarkers;Clinical Research;Clinical Trials;Cognition;Cohort Studies;Communities;Companions;comparative;comparative efficacy;congenital heart abnormality;Data;Delusions;Depersonalization;Development;Diagnosis;Diagnostic;Disease;Disparate;Down's Syndrome;Electroconvulsive Therapy;Electroencephalography;Epilepsy;Etiology;Evaluation;functional decline;Future;Gene Proteins;General Population;Genetic Diseases;Hallucinations;Health;Homeostasis;Hyperactivity;Immune;Immunology;Immunotherapy;improved;Individual;inflammatory marker;inhibitor;insight;Intellectual functioning disability;Interferon Activation;Interferons;Intervention;Intravenous Immunoglobulins;Investigation;Language;leukemia;Link;Live Birth;Lorazepam;Magnetic Resonance Imaging;Measurement;Medical;medication administration;Medicine;member;Modality;Monitor;Motor;Movement;multidisciplinary;Mutism;Nerve Degeneration;neuroimaging;neuroinflammation;Neurologic;Neurology;neuropsychiatry;neurotoxic;open label;Participant;Pharmaceutical Preparations;Phase II Clinical Trials;phase II trial;Plasma;Prevalence;primary endpoint;programs;proteomic signature;Psychiatry;Quality of life;Randomized;Reporting;Research;response;Risk;Role;Safety;Sampling;Signal Pathway;Signal Transduction;Sleep;Speech;symptomatic improvement;Symptoms;Therapeutic;Therapeutic Intervention;treatment arm;treatment duration;treatment response;United States;Work

PROJECT_TITLE: Mechanistic investigation of therapies for Down Syndrome Regression Disorder


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PI_NAMEs: HUANG, ELBERT S. (contact);LYNCH, ELIZABETH B

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TITLE: Administrative Core


ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Patients with severe infections need drugs to restore their immune system. We search for antiviral drugs that will help restore the immune response to virus infections. Our experiments seek to identify new information on how coronavirus alters the immune system to help in the design of new therapies.

PI_NAMEs: WARE, CARL F (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Agonist;antagonist;Anti-viral Agents;betacoronavirus;Bioinformatics;Biological Assay;biosafety level 3 facility;candidate selection;Cell Line;Cells;Collaborations;Complex;Coronavirus;Coronavirus Infections;COVID-19;COVID-19 pandemic;COVID-19 patient;Critical Pathways;cytokine;cytokine release syndrome;Cytokine Signaling;Data Analyses;Defense Mechanisms;design;Disease;Distal;Drug Design;drug development;Drug Screening;evidence base;experimental study;Faculty;Future Generations;Gene Modified;Genetic;Genetic Transcription;Genome;genome-wide;Goals;herpesvirus entry mediator;high voltage electron microscopy;Host Defense;Human;Immune Evasion;Immune response;Immune system;Immunology;immunopathology;Infection;Inflammatory;inhibitor;Interferons;Interleukin-1;Knowledge;knowledge base;Libraries;Life;Lung;Lung infections;lymphotoxin beta receptor;lytic replication;Mediating;Modeling;Murine hepatitis virus;Mus;novel;novel therapeutics;Organ;Organoids;Outcome;Papain;pathogen;Pathway interactions;Patients;Peptide Hydrolases;Pharmaceutical Preparations;pharmacologic;Principal Investigator;Production;Productivity;Protein Chemistry;protein complex;Proteins;Proteome;Proteomics;rational design;receptor;Reporter;Respiratory Tract Infections;Role;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;Scientist;screening;severe COVID-19;Signal Pathway;Signal Transduction;success;System;Testing;Therapeutic;Tissues;TNF receptor-associated factor 3;tool;transcriptome;transcriptome sequencing;transcriptomics;Vaccines;Viral;Viral Proteins;virology;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Overriding the Immune Evasion Tactics of Coronavirus


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: BROOKLYN

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: Project Narrative Despite widespread recognition of the benefit of having more than one mentor for success in biomedical research, the roles and types of mentors important for early career researchers is not well-understood. This application will identify and test patterns of successful mentorship networks to enhance biomedical research outcomes and close mentoring gaps for trainees from underrepresented backgrounds.

PI_NAMEs: LAMBERT, WILLIAM MARCUS (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Academia;Academic support;Affect;Biomedical Research;career;career development;Characteristics;Disparity;Faculty;feasibility testing;Funding;Goals;Grant;Individual;Intervention;Investments;Maps;Measures;meetings;Mentors;Mentorship;Modeling;Outcome;Outcomes Research;Pathway Analysis;Pattern;Persons;Postdoctoral Fellow;primary outcome;Program Development;psychosocial;Psychosocial Assessment and Care;Publications;Research;Research Personnel;Research Training;Role;Science;secondary outcome;Self Efficacy;success;Testing;Time;tool;Training;trend;Underrepresented Populations

PROJECT_TITLE: Understanding the Science of Effective Mentorship Networks for Underrepresented Researchers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-L(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

ORG_DEPT: BIOLOGY

PHR: The cross-species emergence of SARS-CoV-2 from wild, Rhinolophus spp. bats to human hosts highlights the extreme public health, economic, and societal consequences that can result from zoonotic spillover. This proposal leverages tools from mathematical modeling, field biology, and molecular immunology to decipher the mechanisms underpinning the circulation of bat-borne viruses at a population-level, understand the processes which shape their pathology within-host, and eradicate them from reservoir populations to prevent future threats of zoonotic emergence.

PI_NAMEs: BROOK, CARA  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 2019-nCoV;Address;African;Animals;Anti-Inflammatory Agents;antiviral immunity;bat-borne;betacoronavirus;Biology;Canis familiaris;Case Fatality Rates;Cell Line;Chicago;Chiroptera;chronic infection;Circulation;Clinical;Collaborations;Communicable Diseases;Communities;Consumption;Coronavirus;cost effective;Coupled;COVID-19 pandemic effects;cross-species transmission;Data;design;Discipline;Disease;Disparate;Doctor of Philosophy;Ebola;Ecology;Economics;Ecosystem;Evolution;Exhibits;experience;exposed human population;Exposure to;field study;Filovirus;Food;Fruit;Future;Goals;Hendra Virus;Henipavirus;Henipavirus Infections;Human;Immune;Immune system;Immunity;Immunologics;immunopathology;Infection;Infection Control;infectious disease model;Innate Immune Response;innovation;interest;Intervention;Island;Jamaican;Laboratories;Learning;Link;Literature;Madagascar;Mammals;Marburgvirus;mathematical model;Measles;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Modeling;Molecular;Molecular Immunology;Monitor;Nature;Nipah Virus;novel;Nutritional;pandemic preparedness;Paramyxovirus;pathogen;Pathology;Pattern;Periodicals;Physiologic pulse;Physiological;Physiology;Population;Population Sizes;Population Study;post-doctoral training;Postdoctoral Fellow;prevent;Prevention;Process;professor;Public Health;Rabies virus;Recommendation;Recrudescences;Regimen;reproductive;Research;Resources;Sampling;Seasonal Variations;Seasons;Series;Serology;Severe Acute Respiratory Syndrome;Shapes;skills;Source;spillover event;Stress;stressor;System;Techniques;Testing;therapy design;Time;tool;transmission process;United States National Institutes of Health;Universities;Vaccinated;Vaccination;vaccine distribution;Vaccines;Viral;Viral Load result;viral transmission;Virulent;Virus;Virus Diseases;Virus Shedding;willingness;Work;Zoonoses;zoonotic spillover

PROJECT_TITLE: Crossing scales to predict and prevent bat virus zoonoses in a Madagascar ecosystem


ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: SeroNet UO1- Remaining Activities 2025 Zidar David, Timothy Chan | 1 U01 CA 260513 Pre-exposure Immunologic Health and Linkages to SARS-COV2 Serologic Responses, Endothelial Cell Resilience, and Cardiovascular Complications: Defining the mechanistic basis of high risk endotypes. Project Narrative COVID-19, the disease resulting from SARS-CoV2 infection, has caused immeasurable death and economic hardship across the globe within months. Certain individuals, including those with impaired immune function and/or those with heart disease appear to be a higher risk from COVID19. Whether survivors develop protection from a second exposure add to the urgency to understand the details of how COVID causes death. Here, we will characterize baseline differences in immunologic activation and risk factors for heart disease and how these relate to immune system function after infection. We will also compare those who do and don’t develop heart failure in response to COVID19, identifying ways the virus may directly or indirectly attack distant organs such as the heart. By identifying the mechanisms which explain why some develop life-threatening disease whereas others are minimally affected, we hope to develop strategies to identify and prevent severe illness from developing in those with COVID.

PI_NAMEs: CHAN, TIMOTHY AN-THY;ZIDAR, DAVID A. (contact)

PROJECT_TERMS: 2019-nCoV;Affect;Antibody Response;Cardiac;Cardiac Myocytes;cardiovascular disorder risk;Cardiovascular system;Cause of Death;Cells;cellular resilience;Cessation of life;COVID-19;COVID-19 impact;COVID-19 mortality;COVID-19 pneumonia;COVID-19 risk;Disease;Distant;Down-Regulation;Economics;Endothelial Cells;Endothelium;Enrollment;experimental study;Foundations;Functional disorder;Health Personnel;Heart;Heart Diseases;Heart failure;high risk;Immune;immune activation;immune function;immune health;Immune System Diseases;immune system function;Immunologics;Impairment;improved;In Vitro;Individual;Infection;Inflammatory;Left Ventricular Dysfunction;Life;Link;Maintenance;Modeling;Molecular Profiling;Nature;neutralizing antibody;Nodal;Organ;Pathway interactions;prevent;Recovery;response;Risk;Risk Factors;SARS-CoV-2 infection;Serology;Severities;single cell sequencing;Stimulus;Survivors;Symptoms;Techniques;Tissues;Virus


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Childhood Obesity;Clinical Research;Endocrine Disruptors;Foodborne Illness;Nutrition;Obesity;Pediatric;Pregnancy;Prevention

ORG_NAME: BROWN UNIVERSITY

PHR: Project Narrative Prenatal exposure to perfluoroalkyl substances (PFAS) is ubiquitous in the United States and may increase the risk of adolescent obesity, elevated blood pressure, dyslipidemia, and insulin resistance. Identifying biological markers of these effects is critical to ongoing regulation of PFAS and may reduce the impact of PFAS-related toxicities. This project will use sophisticated analytical chemistry and biostatistical methods to understand the links between prenatal exposure to PFAS mixtures, metabolomic biomarkers, and adolescent cardiometabolic disease.

PI_NAMEs: BRAUN, JOSEPH M (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: 12 year old;Acceleration;Address;Adolescent;adolescent health;Adolescent obesity;Adult;Affect;Age;Amino Acids;Analytical Chemistry;Animals;Area;Biological;Biological Markers;Biometry;Biostatistical Methods;Blood;blood pressure elevation;Canada;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Carnitine;Chemical Exposure;Chemicals;Child;Childhood;Cohort Studies;Collaborations;Collection;Commerce;contaminated drinking water;Coupled;critical period;Data;Databases;Diet;dimension reduction;disorder risk;Dissociation;drinking water;Dyslipidemias;early adolescence;early life exposure;Environment;environmental chemical;environmental chemistry;Epidemiologist;Epidemiology;Evaluation;Exposure to;Fatty Acids;Fire - disasters;Food;Food Contamination;Food Packaging;Growth;Health;health assessment;Home;Human;Hypertension;improved;Individual;Industry;innovation;Insulin Resistance;Ions;Knowledge;landfill;late life;Life;Link;liquid chromatography mass spectrometry;manufacture;manufacturing facility;maternal serum;Measures;Mediating;Metabolic;Metabolism;metabolome;metabolomics;microbiome;Modeling;neonate;novel;Obesity;obesity risk;Ohio;Oils;Outcome;Pathway interactions;Pediatrics;Persons;Plasma;Poly-fluoroalkyl substances;Populations at Risk;Predisposition;Pregnancy;Pregnant Women;prenatal;prenatal exposure;Productivity;Prospective cohort;Publishing;Recording of previous events;Regulation;Research Personnel;Resolution;response;Risk;Risk Factors;Sampling;Serum;small molecule;Syndrome;Techniques;Testing;Textiles;Time;Toxic effect;Training;United States;Water

PROJECT_TITLE: Gestational PFAS Mixture Exposures, Longitudinal Metabolomic Profiles, and Adolescent Cardiometabolic Health

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: Narrative: We are studying the neurological effects of COVID-19, also known as neuroCOVID-19. We are particularly interested in the role of antibodies in these effects. We believe that inflammatory antibodies associated with the SARS-CoV-2 virus can cause damage to the cells in our brains and disrupt their normal functioning. These inflammatory antibodies may also have a special affinity for targeting brain cells. Through laboratory experiments and animal models, we aim to understand the role of these antibodies in neuroCOVID-19. This research has implications for developing targeted therapies for COVID-19-related neurological complications

PI_NAMEs: AL-HARTHI, LENA  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: 2019-nCoV;Acute;Address;Affinity;Animal Model;Anti-Inflammatory Agents;Antibodies;Antigen Targeting;Antigens;Astrocytes;Autoantibodies;Autopsy;autoreactivity;Brain;brain cell;brain endothelial cell;Brain region;Case Study;cell injury;Cells;Cerebrospinal Fluid;COVID-19;COVID-19 impact;COVID-19 patient;COVID-19 treatment;Cross Reactions;Data;density;Development;Encephalopathies;Endothelial Cells;Epitopes;Etiology;Event;Exhibits;Experimental Models;Frequencies;glycosylation;Guillain Barré Syndrome;Hemorrhage;Homeostasis;Human;human induced pluripotent stem cells;human tissue;Immune response;Immunoglobulin G;immunoregulation;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Infarction;Inflammation;Inflammatory;Inflammatory Response;Infusion procedures;insight;interest;Investigation;Ischemia;Label;laboratory experiment;Link;Mediating;Memory impairment;Microglia;Minority;Modification;Mus;N-Methyl-D-Aspartate Receptors;Nerve Tissue Proteins;Neurocognitive Deficit;neurofascin;Neuroglia;neuroinflammation;Neurologic;Neurologic Effect;Neurologic Symptoms;Neurons;neuropathology;olfactory bulb;Outcomes Research;pathogen;Pattern;Peripheral Nerves;Phenotype;Plasma;Prevalence;Process;Protein Microchips;Reporting;Research;response;RNA;Role;SARS-CoV-2 infection;Severity of illness;Structure;sugar;symptomatic COVID-19;targeted treatment;Testing;Therapeutic Intervention;Tissues;trafficking;vaccine response;Viral;Viral Proteins;viral RNA;Virus

PROJECT_TITLE: Antibodies in the neurologic effects of COVID-19

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-T(57)R]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PI_NAMEs: FREEDMAN, BENJAMIN SOLOMON;HIMMELFARB, JONATHAN  (contact);KELLY, EDWARD J

PROGRAM_OFFICER_NAME: HARGROVE, PASSLEY R


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision

ORG_CITY: OXFORD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MIAMI UNIVERSITY OXFORD

PHR: Project Narrative This project will create and test high-quality phantoms that mimic human tissues to improve a new imaging technique for early disease detection. These phantoms will help ensure the accuracy and reliability of this new technology before it is used on patients.

PI_NAMEs: WANG, HUI  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Address;Adoption;Algorithms;Animals;Anisotropy;attenuation;Biological;Calibration;Clinical;clinical diagnostics;clinically relevant;Communities;Detection;Development;Diagnosis;diagnostic value;Disease;Documentation;early detection biomarkers;Early Diagnosis;Ensure;fabrication;Glaucoma;Goals;Grant;human tissue;Image;imaging modality;Imaging Phantoms;imaging system;Imaging Techniques;improved;in vivo;in vivo evaluation;Libraries;Link;Measurement;Measures;Medical;Modeling;Morphology;National Institute of Biomedical Imaging and Bioengineering;new technology;novel;Optical Coherence Tomography;optical imaging;Optics;Outcome;parent grant;Pathologic;Patients;Performance;Photons;Property;Protocols documentation;Reference Standards;reflectance confocal microscopy;Reproducibility;Resolution;Retina;retinal nerve fiber layer;Series;simulation;Skin;Solid;Structure;System;Technology;Test Result;Testing;tissue phantom;Tissues;tool;Translations;Uncertainty;Validation;Variant;Visualization

PROJECT_TITLE: Fabrication of solid and long-lasting phantoms for calibrating parametric OCT imaging


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Public Health Narrative The proposal seeks to address key obstacles that must be overcome to achieve enzyme-less nanopore-based low-cost high-speed sequencing of chromosomal length DNA molecules. Fast and low cost full genome DNA sequencing will allow, for example, major improvements in the understanding, diagnosis, treatment and pre- vention of disease, and significant advances in evolutionary research and the understanding of cellular opera- tion.

PI_NAMEs: DRNDIC, MARIJA ;SHEPARD, KENNETH L (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TITLE: Enzymeless, controlled electrostatic ratcheting in solid-state nanopores


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Our long-term goal is to eliminate racial disparities in chronic kidney disease progression, treatment, and care among patients within Emory Healthcare, the state’s largest healthcare system, by developing a model of care that can be replicated and sustained within health systems across the country. In the development, implementation, evaluation, and dissemination of multi-component, multi-level interventions that mitigate the impact of structural racism on healthcare delivery we will rely heavily on a community-engaged approach at all stages of implementation to maximize the impact of these interventions on patients, providers, and treatment settings. Doing so is expected to have an important positive impact on the field of public health and the mission of NIDDK through the generation of health, organizational, and implementation outcomes.

PI_NAMEs: ARRIOLA, KIMBERLY RUTH JACOB (contact)

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Accounting;acute care;Address;Administrative Supplement;African American;African American population;Allografting;anti-racism;arm;Attention;Automobile Driving;base;Black American;Blinded;burnout;care outcomes;Caring;chronic care model;Chronic Disease;Chronic Kidney Failure;Client satisfaction;Clinical;Collaborations;community advisory board;community engaged approach;Computerized Medical Record;Country;design;Development;Dialysis procedure;disease disparity;Disease Progression;disorder prevention;Disparity;Donor person;Educational Curriculum;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Elements;Employment;Equation;Evaluation;Failure;Funding;Future;Generations;Goals;hazard;Health;health care delivery;health care settings;health equity;health organization;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Home Hemodialysis;implementation evaluation;implementation outcomes;implicit bias;Improve Access;improved;inclusion criteria;Income;Individual;Inequity;innovation;interest;Interruption;Intervention;Kidney;Kidney Diseases;Kidney Failure;Knowledge;lens;Link;Mission;Modeling;multi-component intervention;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Organ Preservation;Outcome;Parents;Pathway interactions;patient population;patient registry;Patient-Centered Care;Patient-Focused Outcomes;Patients;Physicians;Population;Primary Care;primary outcome;Process;Provider;Public Health;Public Health Applications Research;Publishing;Quality of life;Quasi-experiment;Race;racial disparity;racism;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Registries;Research;Risk;Role;Sample Size;Science;Series;social determinants;social health determinants;Statistical Data Interpretation;Structural Racism;Structure;System;Time;tool;Transplantation;treatment arm;treatment as usual;treatment group;Treatment outcome;treatment trial;United States National Institutes of Health

PROJECT_TITLE: CLARIFy-KD Kidney Health Coaching Supplement