NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: PROJECT NARRATIVE Opioid overdose deaths have skyrocketed by 3.5x in the last decade, mainly due to “respiratory depression,” i.e., slowed breathing or cessation of breathing. Understanding the mechanisms underpinning this is a critical first step towards prevention and the development of new effective interventions. This project will not only provide a deeper understanding of the unique influence of the mu opioid receptor subtypes on opioid-induced respiratory depression, mediated by two brain regions crucial for regulating respiratory function, but will also enable the development of potential therapeutic strategies to reduce unnecessary opioid-related deaths.

PI_NAMEs: MALIK, AYMA  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Absence of pain sensation;abuse liability;addiction;Alternative Splicing;Astrocytes;Back;Behavioral;Biological Assay;Brain region;Brain Stem;Breathing;Breeding;Categories;Cause of Death;cell type;Cells;Code;combat;Complex;Comprehension;conditional knockout;Cytomegalovirus;Data;Dependence;Development;Distress;Dose;effective intervention;effective therapy;Exons;Fellowship;Fentanyl;gastrointestinal;Gene Targeting;Human;illicit opioid;Immunohistochemistry;insight;International;Introns;Investigation;Knock-out;Laboratories;Lead;Literature;LoxP-flanked allele;Maps;Mediating;Messenger RNA;Microglia;Microinjections;Modeling;Molecular;Morphine;mouse model;mu opioid receptors;Mus;Neuroglia;Neurons;novel therapeutic intervention;Oligodendroglia;Opioid;opioid epidemic;opioid mortality;opioid overdose;Opium;Oxygen;Pain management;parabrachial nucleus;Peripheral;Pharmaceutical Preparations;Pharmacology;Physical Dependence;Play;preBotzinger complex;prescription opioid;Prevention;Pruritus;Publications;Rattus;Receptor Gene;Reporting;Respiration;respiratory;Respiratory physiology;Rewards;RNA Splicing;Rodent;Role;sex;side effect;Site;Synapses;Technology;Testing;Therapeutic;Tissues;Training;Transmembrane Domain;United States;Variant;Ventilatory Depression;Whole Body Plethysmography

PROJECT_TITLE: Exploring the Role of Alternatively Spliced Variants of the Mu Opioid Receptor Gene, Oprm1, in Opioid-Induced Respiratory Depression in Gene Targeted Rat Models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Contraception/Reproduction;Drug Abuse (NIDA only);Estrogen;Neurosciences;Opioid Misuse and Addiction;Opioids;Precision Medicine;Substance Misuse;Women's Health Research

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_STATE: NJ

PHR: Project Narrative The ovulatory phase of the menstrual cycle seems to align with increased risk-taking and sensitivity to reward cues, such as drug rewards. These observations combined with the historic underrepresentation of women (/sex- specific underrepresentation of females) in research studies and differential opioid use disorder treatment outcomes seen by sex, indicate a crucial need to better understand the interaction between ovarian hormones and reward processes in opioid use disorder. In doing so, new neural and behavioral targets for sex-specific personalized treatment protocols may be elucidated.

PI_NAMEs: LOFARO, FRANCESCA  (contact)

PROJECT_TERMS: Abstinence;Active Learning;addiction;Address;Behavior;Behavioral;Brain;Cessation of life;Clinical;clinical predictive model;clinical translation;clinically relevant;Communication;comparison control;Computer Models;connectome;Cues;Data;Decision Making;demographics;Development;Diestrus;disorder control;Dopamine;Dropout;Drops;drug craving;drug reward;Drug usage;drug use vulnerability;Estrogens;Estrus;Exclusion;Female;Foundations;Functional Magnetic Resonance Imaging;Goals;Health;Hormonal;Hormones;Human;Individual;insight;Intervention;Knowledge;Laboratories;learning strategy;Linear Models;Literature;Longitudinal Studies;male;Maps;Measures;men;Menstrual cycle;Menstruation;Mentorship;Methods;Modeling;Motivation;Mus;network architecture;neural;Neurocognitive;neuroeconomics;neuroimaging;neuromechanism;Neurosciences Research;neurotransmission;novel strategies;Opioid;opioid use disorder;Outcome;Ovarian Cycles;Ovarian hormone;Overdose;Ovulation;Participant;Pathway interactions;personalized medicine;Persons;Pharmaceutical Preparations;Phase;Population;Population Group;pre-clinical;Probability;Process;Progesterone;Psychiatric Diagnosis;Psychiatric therapeutic procedure;Public Health;Relapse;Reporting;Research;Research Personnel;research study;response;Rest;Rewards;Risk;Risk Marker;Risk Taking;Rodent;saliva sample;Sampling;Sampling Studies;Scanning;sex;Sex Differences;Signal Transduction;substance use;success;theories;Time;Training;Treatment outcome;Treatment Protocols;Underrepresented Populations;Ventral Striatum;Woman;Work

PROJECT_TITLE: Elucidating How Menstrual Cycle Phase Influences Neurocognitive Processes Underlying Risk-Taking in Women with Opioid Use Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Contraception/Reproduction;Infertility;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Autism spectrum disorder (ASD) prevalence is increasing, yet its etiology is largely unknown. It is important to explore possible causes of ASD that occur in the perinatal period, as early identification leads to better outcomes. The proposed analysis uses the Study to Explore Early Develop (SEED) to determine if variability in the perinatal hormonal environment is associated with ASD. The proposed aims align with NICHD’s strategic goal “setting the foundation for healthy pregnancies and lifelong wellness”.

PI_NAMEs: DELAHANTY, MICHELLE TERESE (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Affect;Animals;Anxiety;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;career;Caregivers;Case/Control Studies;Chemicals;Child;Child Development;Classification;Communication;comparison control;Complex;Conceptions;Contraceptive Agents;cost;Counseling;Data;Data Analyses;Development;Diagnosis;doctoral student;Early Diagnosis;Early identification;Early Intervention;early screening;Education;Endocrine System Diseases;endometriosis;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Estrogens;Etiology;Exogenous Hormone Therapy;Fellowship;fetal;Fetus;Foundations;Functional disorder;Funding;Genetic;Genetic Diseases;Goals;Growth and Development function;Healthcare;healthy pregnancy;Heterogeneity;high risk;Hormonal;hormonal contraception;Hormones;Individual;Infection;infertility treatment;Intervention;Learning;Life;Logistic Regressions;Measures;Mental Depression;Metabolic;Methodology;Modeling;National Institute of Child Health and Human Development;neurodevelopment;Neurosecretory Systems;North Carolina;Outcome;Participant;Patients;Pediatric epidemiology;Perinatal;perinatal environment;Perinatal Epidemiology;perinatal period;Persons;Phenotype;Placenta;Play;Polycystic Ovary Syndrome;Postpartum Period;pre-doctoral;Pregnancy;pregnant;prenatal;Prevalence;prevent;Probability;Production;Progesterone;Progestins;repetitive behavior;Reporting;Reproduction;reproductive epidemiology;Research;Research Design;Research Personnel;Resources;Risk;Role;screening;Self-Injurious Behavior;Severities;Site;skills;steroid hormone;subfertility;Subgroup;Testosterone;Thyroid Gland;Training;Training Programs;treatment comparison;United States;Universities;Uterine Fibroids;Weight;Work

PROJECT_TITLE: Variability in the Perinatal Hormone Environment and Risk of Autism Spectrum Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: AMERICAN GERIATRICS SOCIETY

ORG_STATE: NY

PHR: PROJECT NARRATIVE  We propose a new American Geriatrics Society (AGS) Advancing the Science of Multiple Chronic Conditions (MCCs) in Older Adults R13 conference series. The mission of this conference grant is to deepen research efforts relating to the science of MCCs in older adults, with the potential to greatly improve the health and healthcare of the growing population of older people living with MCCs.

PI_NAMEs: GURWITZ, JERRY H (contact);LUNDEBJERG, NANCY E.

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acceleration;Address;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;bench to bedside;career;career development;Career Mobility;Caring;Chronic;Clinical;clinical care;clinical decision-making;clinical practice;Clinical Research;Clinical Trials;comorbidity;Development;Disease;Education;Educational Curriculum;Elderly;Epidemiology;evidence base;frailty;Funding;Gender;Geriatrics;Goals;Grant;Growth;Health;health equity promotion;Health Professional;Healthcare;Healthcare Systems;improved;Inflammation;Infrastructure;innovation;interdisciplinary collaboration;Interdisciplinary Study;interest;Knowledge;Learning;Life Cycle Stages;Manuscripts;medical specialties;Mentorship;minority scientist;Mission;multidisciplinary;multiple chronic conditions;National Institute on Aging;next generation;nutrition;older adult;Older Population;Patients;person centered;Persons;Physicians;Pragmatic clinical trial;prevent;Prevention;Publications;Research;Research Infrastructure;Research Methodology;Research Personnel;resilience;Running;Scholars Program;Science;Scientist;Series;sex;Societies;Specialist;success;symposium;Syndrome;systems research;Training;translational pipeline;Translations;Underrepresented Minority;United States;United States National Institutes of Health;Voice

PROJECT_TITLE: Advancing the Science of Multiple Chronic Conditions in Older Adults

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: The VA and Offices of Connected Care have previously implemented a digital divide consult which provided video-enabled tablets to Veterans experiencing virtual care barriers. However, recent Office of Inspector General Reports find only half of all distributed tablets are being used. Data suggests one potential barrier to the use of such tablets is the lack of digital literacy and inexperience with digital tools. This proposal implements and assesses a pilot intervention to improve digital literacy among hospitalized Veterans. This proposal will test the efficacy of a personalized digital training intervention delivered at the bedside to improve MyHealtheVet (MHV) and VA Video Connect (VVC) uptake. We hypothesize Veterans who receive inpatient digital training will increase their post-hospitalization use of MHV and VVC. Pilot support is needed to test the feasibility of these methods to inform a larger randomized pragmatic, randomized study of this intervention.

PI_NAMEs: O'SHEA, AMY MJ (contact)

PROJECT_TERMS: Accident and Emergency department;Address;Appointment;arm;Caregivers;Caring;Cities;Clinical;Cluster randomized trial;Complex;connected care;Consult;cost;Data;data warehouse;design;Devices;Diabetes Mellitus;digital;digital divide;digital tool;E-learning;Educational Intervention;Educational Materials;Effectiveness;effectiveness evaluation;efficacy testing;Electronic Health Record;Eligibility Determination;Environment;experience;Feasibility Studies;feasibility testing;Feedback;follow-up;Goals;Guidelines;handheld mobile device;Health;health care service utilization;Health Services Accessibility;high risk population;Homogeneously Staining Region;hospital readmission;hospital utilization;Hospitalization;hospitalization rates;Hospitals;Hypertension;implementation strategy;improved;innovation;Inpatients;insight;Internet;Intervention;Intervention Studies;Interview;Iowa;Length of Stay;literacy;Measures;Medical;Medical center;medical specialties;medical vulnerability;meetings;Mental Health;Methodology;Methods;Needs Assessment;Notification;Outcome;Outpatients;patient portal;Patients;Persons;Pilot Projects;pilot trial;Population;post-pandemic;pragmatic trial;preference;prevent;Primary Care;primary care visit;Process;programs;Provider;Questionnaires;Randomized;readmission rates;Recommendation;Reporting;Resources;Rural Health;San Francisco;satisfaction;secondary outcome;Services;Site;skills;Structure;success;Suggestion;Surveys;Tablets;Technology;Telemedicine;telephone based;Telephone Interviews;Time;Training;training opportunity;Transportation;uptake;Veterans;Veterans Health Administration;virtual;virtual healthcare;Visit;Work;Writing

PROJECT_TITLE: A Pilot Digital Literacy Intervention to Engage Hospitalized Veterans with MyHealtheVet and VA Video Connect

STUDY_SECTION_NAME: HSR-3 Healthcare Informatics[HSR3]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: WASHINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE Presynaptic Homeostatic Potentiation (PHP) plays a vital role in maintaining synaptic stability and adaptability, particularly in response to perturbations in postsynaptic glutamate receptors. This project targets a critical aspect of neural function: identifying and studying the matrix metalloproteinase that cleaves the extracellular matrix (ECM) protein Multiplexin, thereby releasing Endostatin, critical in PHP. Given the association of Multiplexin with serious neurological conditions, elucidating how matrix metalloproteinase processes Multiplexin for synaptic stabilization could revolutionize treatment strategies for neurological disorders, significantly advancing our approach to brain health and disease management.

PI_NAMEs: CAI, YIMEI  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Acute;Alleles;Alzheimer's Disease;Architecture;autism spectrum disorder;behavior influence;behavioral response;Biochemical;Biochemistry;Biological Assay;Brain;brain health;Bypass;C-terminal;Calcium;Calcium Channel;Cell Differentiation process;Cell Line;cell type;Cells;Central Nervous System;Chemosensitization;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen;Compensation;Complex;cost effectiveness;CRISPR/Cas technology;Data;density;Disease Management;Drosophila genus;Electrophysiology (science);Elements;Endostatins;Ensure;Epilepsy;Experimental Designs;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;fly;Functional disorder;Gelatinase A;Genes;Genetic;Genetic Screening;Genetic study;genome editing;Glutamate Receptor;Glutamates;health management;Homeostasis;Homologous Gene;Human;Image;Immunohistochemistry;information processing;Information Storage;insight;interdisciplinary approach;Interstitial Collagenase;Learning;Length;Link;Maintenance;Mammals;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;MMP2 gene;Modeling;Molecular;Motor Neurons;Muscle;mutant;N-terminal;Nature;Nerve Degeneration;Nervous System;Nervous System Disorder;Neurologic;Neurology;Neuromuscular Junction;Neurons;Neurophysiology - biologic function;neurotransmitter release;Output;overexpression;P-Q type voltage-dependent calcium channel;Peptide Hydrolases;Peripheral Nervous System;Pharmacology Study;Physiological;Play;Polysaccharides;postsynaptic;presynaptic;presynaptic neurons;Process;Property;Proteins;Receptor Inhibition;Regulation;Research;response;RNA Interference;Role;Schizophrenia;sensor;Side;Signal Pathway;Signal Transduction;Signaling Molecule;Structure;Study models;superresolution imaging;Synapses;synaptic function;Synaptic plasticity;Techniques;Testing;Thrombospondins;Tissues;tool;transmission process;treatment strategy;triple helix;vesicular release;voltage

PROJECT_TITLE: Matrix Metalloproteinase 2 Controls Trans-Synaptic Homeostatic Plasticity in Drosophila

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Unlike private insurance plans and Medicaid, Medicare, which provides health insurance coverage to nearly 1.5 million women of reproductive age with disabilities, does not cover most contraceptive methods for pregnancy prevention. This project will assess whether Medicare’s contraceptive coverage policies restrict contraceptive method use among enrollees with disabilities. Analyses will inform federal health insurance policies to ensure that they are meeting the reproductive healthcare needs of people with disabilities.

PI_NAMEs: BELLEROSE, MEGHAN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Adult;adverse pregnancy outcome;Age;aged;Arthralgia;care outcomes;career;Chronic disability;Collaborations;Communication;community advisory board;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Cost Sharing;Data;Data Analyses;disability;Disability Insurance;Disabled Persons;Drug Prescriptions;Dual Enrollment;econometrics;Educational process of instructing;Eligibility Determination;Enrollment;Environment;experience;FDA approved;federal poverty level;Gerontology;Goals;Health Benefit;health care availability;Health Care Research;Health Insurance;Health Policy;Healthcare;Hearing;Household;Hypertension;implantable device;improved;Income;Individual;Injections;Inpatients;Institution;Insurance Coverage;insurance plan;Interdisciplinary Study;interest;Interview;Intrauterine Devices;Laws;Low income;Medicaid;Medicare;Medicare/Medicaid;meetings;Mental Depression;Mental disorders;Methods;Musculoskeletal Diseases;National Institute of Child Health and Human Development;Outpatients;Patients;payment;perinatal health;person centered;Persons;Pharmacologic Substance;pill;Policies;Policy Maker;Postpartum Period;Pregnancy;pregnancy disorder;pregnancy prevention;Premature Birth;Privatization;professor;programs;Public Health Schools;Qualifying;reproductive;Reproductive Health;Reproductive Health Services;Research;Research Personnel;reversible contraceptive;Risk;Social Security;Spontaneous abortion;Supplemental Security Income;Training;Training Activity;Tubal Ligation;Uninsured Medical Expense;unintended pregnancy;United States;Universities;Vision;Woman;women with disabilities

PROJECT_TITLE: Impact of Medicare and Medicaid coverage policies on contraceptive use among people with disabilities


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Anxiety Disorders;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Complementary and Integrative Health;Dementia;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Alzheimer’s disease (AD) is the most prevalent type of dementia and currently has no definitive cause; however, certain neuropsychiatric disorders such as anxiety may predict and promote AD progression. The proposed research will investigate the physiological mechanisms of anxiety interventions and predict positive intervention response. The resulting findings will provide insight that can lead to precision interventions to alleviate anxiety and its associated impact on AD progression.

PI_NAMEs: STOLTE, SKYLAR E (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Academia;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Anxiety;Anxiety Disorders;anxiety symptoms;Area;Artificial Intelligence;Behavior Control;Brain;Brain region;career;cingulate cortex;Classification;Clinical;Cognitive;Cognitive Therapy;cognitive training;Collaborations;Collection;convolutional neural network;Data;Decision Making;deep learning;Dementia;design;Disease;Disease Progression;Economics;Educational process of instructing;effective intervention;Effectiveness;effectiveness testing;Environmental Risk Factor;Equipment and supply inventories;experience;experimental study;Exposure to;follow-up;Fostering;Functional Magnetic Resonance Imaging;Genetic;Heterogeneity;improved;Individual;individual response;insight;interest;Intervention;Knowledge;Left;Life;Life Expectancy;lifestyle factors;Machine Learning;Magnetic Resonance Imaging;Maps;Mental Depression;Mentors;Methods;mild cognitive impairment;Modeling;neglect;neural;neuroimaging;neurophysiology;Neurophysiology - biologic function;neuropsychiatric disorder;older adult;Outcome;Outcome Measure;outcome prediction;Participant;Pathway interactions;Patients;personalized intervention;Persons;pharmacologic;Phase;Physiological;Population;predicting response;Prefrontal Cortex;Prevalence;prevent;psychologic;randomized, clinical trials;reduce symptoms;Research;research faculty;responders and non-responders;response;skills;support vector machine;Techniques;Testing;Therapeutic Intervention;tool;Training;trait;transcranial direct current stimulation;United States;Visit;Visualization;Work

PROJECT_TITLE: Mechanism, connectivity, and outcome prediction of anxiety intervention from MRI-derived models in tDCS augmented cognitive training

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Heterotopic ossification (HO) is a debilitating condition involving formation of pathologic bone in extra-skeletal soft tissues. These studies are designed to advance our knowledge on the cellular mechanisms driving HO, and to discover new therapeutic small RNA-nanoparticle targeting approaches to treat this condition.

PI_NAMEs: MCALINDEN, AUDREY  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: 3' Untranslated Regions;achilles tendon;Actins;Address;Anti-Inflammatory Agents;Automobile Driving;Behavior assessment;Binding;bone;Burn injury;burn model;Cell Physiology;Cell Proliferation;cell type;Cells;Clinical;clinically relevant;Complex;Cytoskeleton;Data;design;differential expression;dosage;effective therapy;Epiphysial cartilage;Gene Expression Profile;Genes;Genetic;Heterotopic Ossification;Histology;improved;In Vitro;in vitro Assay;in vivo;in vivo Model;Inflammation;Injury;insight;knock-down;Knock-in Mouse;Knowledge;Lead;Ligaments;long bone;Messenger RNA;microCT;MicroRNAs;Modality;Molecular Target;Monomeric GTP-Binding Proteins;mouse model;multiple omics;Mus;Muscle;nanoparticle;nanoparticle delivery;NF-kappa B;novel;novel therapeutic intervention;novel therapeutics;Orthopedic Surgery;Osteogenesis;overexpression;p65;Pain;Pathologic;Pathologic Processes;Peptides;Play;Process;Proteomics;Publishing;Reporting;response;RNA;Roentgen Rays;Role;Site;Small Interfering RNA;Small RNA;soft tissue;Technology;Tendon structure;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Tissues;transcription factor;transcriptomics;Trauma

PROJECT_TITLE: Small RNA Targeting Approaches to Advance Treatments for Heterotopic Ossification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-L (03)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative  A long-term goal of our research is to understand the visual processing in the inner plexiform layer (IPL) of the retina. Our study will integrate state-of-the-art techniques including mouse genetic, viral technology, optical imaging, electrophysiology, and optogenetics to study distinct amacrine cell types and to understand how they shape ganglion cell responses through inhibitory interactions. Our proposed experiments will provide new insights into pathophysiological neuronal mechanisms of retinal diseases, and help design better strategies for therapy.

PI_NAMEs: ZHU, YONGLING  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Amacrine Cells;Anatomy;Brain;Brain region;cell type;Comprehension;Dedications;Dendrites;design;Detection;Development;Electrophysiology (science);Exhibits;experimental study;Functional Imaging;Funding;ganglion cell;Genetic;Goals;Image;improved;Inhibitory Synapse;Inner Plexiform Layer;insight;interest;Interneurons;Investigation;Label;Light;Maps;Methods;Microscope;Modeling;Morphology;mouse genetics;multitask;Mus;Neurons;object motion;optical imaging;optogenetics;Pattern;Play;postsynaptic;Property;Publishing;receptive field;Research;response;Retina;Retinal Diseases;Retinal Ganglion Cells;Role;Shapes;Signal Transduction;single-cell RNA sequencing;spatiotemporal;Synapses;Techniques;Technology;Testing;Therapeutic;two-photon;Viral;Visual;visual processing

PROJECT_TITLE: Cell types and functional circuitry in the retina

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Lung;Patient Safety;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Sporadic inclusion body myositis (IBM) is an inflammatory disease resulting in skeletal muscle wasting and often swallowing impairment (dysphagia), with dysphagia recognized as the leading contributor to premature mortality due to its associated respiratory complications. Since IBM is a slowly progressive disease, individuals living with IBM and dysphagia may face insidious debilitating health and well-being consequences years before a terminal outcome. Unfortunately, the pathophysiology of swallowing and airway clearance ability is poorly defined, and in response, the proposed study will investigate the impact of IBM on upper aerodigestive function using well-tested assessment methods that will allow the uncovering of critical respiratory-swallowing associations with the long-term goal of improving diagnostic accuracy and treatment efforts.

PI_NAMEs: AMBROCIO, KEVIN RENZ  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Acceleration;accurate diagnostics;Address;adverse outcome;Age;Area;aspirate;Aspiration Pneumonia;Barium swallow;Biomechanics;Bolus Infusion;Clinical;clinical phenotype;Clinical Practice Guideline;cohort;constriction;Coughing;Cross-Sectional Studies;Data;Defense Mechanisms;Deglutition;Deglutition Disorders;design;diagnostic accuracy;Diameter;Disease;Economic Burden;Employment;Esophagus;Event;experience;Face;Functional disorder;Goals;Health;health care economics;healthcare burden;Image;Impairment;impression;improved;Incidence;Inclusion Body Myositis;Individual;Inflammatory;injured airway;innovation;insight;Intervention;Invaded;kinematics;Larynx;Life;life span;Link;Literature;Lung;Maps;Measures;Methods;Modeling;mortality;Motor Neuron Disease;muscle strength;Myositis;National Heart, Lung, and Blood Institute;Neurodegenerative Disorders;novel;Oral;Outcome;Outcome Measure;Parkinson Disease;Pathogenesis;Pathway interactions;Patients;Peak Expiratory Flow Rate;Performance;Personal Satisfaction;Persons;Pharyngeal structure;Physiological;Physiology;Positioning Attribute;Predisposition;Premature Mortality;pressure;prevent;Process;Productivity;Progressive Disease;Psychometrics;Publishing;Quality of life;Reference Values;Reflex action;Reporting;Research;Research Personnel;respiratory;Respiratory Muscles;response;Risk;Safety;Severities;sex;skeletal muscle wasting;skills;sound;Speed;Sporadic Inclusion Body Myopathy;Standardization;Survival Rate;systematic review;Testing;theories;Time;tongue root;Toxic effect;Training;Upper Esophageal Sphincter;vestibular system;Work

PROJECT_TITLE: Profiling Upper Aerodigestive Functioning in Sporadic Inclusion Body Myositis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative How local adaptations over the course of human evolutionary history have contributed to modern traits and disease risks remains largely unknown. The proposed work will decipher functional regulatory variation and its genic mechanisms underlying population genomic signals of evolutionary adaptation. By scaling to thousands of adaptive loci across global ancestry groups, I will generate a functional human adaptation catalog large enough to identify genomic evolutionary trends.

PI_NAMEs: AKERS, JARED FOX (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Affect;Alleles;Architecture;Binding;Biological Assay;Biological Process;Catalogs;causal variant;Cell Line;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR interference;CRISPR screen;Data;Databases;design;Detection;detector;Diet;Disease;disorder risk;Environment;European;Evolution;follow-up;functional genomics;Gene Expression;Gene Frequency;gene function;Gene Targeting;Genes;Genetic Population Study;Genetic Transcription;Genetic Variation;Genome;genome wide association study;genomic locus;genomic signature;genomic tools;Genomics;Genotype;Guide RNA;Health;Human;human population genetics;Left;lens;Libraries;Link;Linkage Disequilibrium;Machine Learning;machine learning algorithm;Maps;Medical;Modernization;Natural Selections;novel;Ontology;pathogen;Pathway Analysis;Pathway interactions;Pattern;Phenotype;Phylogenetic Analysis;pleiotropism;Population;Population Genetics;portability;Prevalence;Quantitative Trait Loci;Recording of previous events;Recurrence;Regulatory Element;Reporter;Resources;RNA library;Role;Signal Transduction;Technology;Testing;Time;tool;trait;transcription factor;trend;Untranslated RNA;Variant;Work

PROJECT_TITLE: Characterization of adaptive cis-regulatory variation across global populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Narrative: The research proposed in this project will employ cutting-edge behavioral analysis tools and neural recording and manipulation techniques to test how caloric need may drive changes in exploratory behavior and associated dopaminergic circuitry. The work will provide novel insight into how dopaminergic circuitry may be modulated in response to non-obviously rewarding stimuli as well as uncover the neural mechanisms underlying the ethologically relevant behavioral adaptation of changes in exploration with caloric depletion.

PI_NAMEs: KAMATH, TARUN  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Affect;agouti protein;Anatomy;Animal Behavior;Animals;Anorexia Nervosa;Automobile Driving;Behavior;Behavioral;Behavioral Assay;Biological Assay;calcium indicator;Caloric Restriction;Caloric Tests;Corpus striatum structure;Decision Making;deprivation;Dopamine;dopaminergic neuron;Eating Disorders;Environment;Exploratory Behavior;Fiber;Food;Genetic;Hunger;Hypothalamic structure;insight;Knowledge;Lead;Link;Measures;Mediating;Midbrain structure;Modeling;Monitor;Movement;Mus;neural;neural circuit;Neural Pathways;neuromechanism;Neurons;novel;optogenetics;Pathway interactions;Pattern;Peptides;Phase;Photometry;Probability;Process;Research;response;Rewards;Shapes;Stimulus;Structure of nucleus infundibularis hypothalami;System;Tail;Techniques;Testing;Time;tool;Translating;Work

PROJECT_TITLE: Characterizing dopaminergic systems changing exploratory behavior in hungry animals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Estrogen;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Among humans and mice, females have greater influenza vaccine-induced immunity and protection than males, which correlates with greater concentrations of estrogen in females. To identify how B cells in females are more responsive and produce more antiviral antibody after vaccination, a mouse model of influenza vaccination will be used to examine how estrogens change cellular metabolism in B cells to cause greater antibody responses and protection after receipt of influenza vaccine. The insights gained will be critical for women’s health and could inform pathways to therapeutically target for improved vaccine outcomes in both men and women.

PI_NAMEs: ST CLAIR, LAURA ATHELLE (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adult;Adult women;Age;Aging;Agonist;Animal Model;antagonist;Antibodies;Antibody Formation;Antibody Response;Antibody-mediated protection;Architecture;ATP Synthesis Pathway;Autophagocytosis;B Cell Proliferation;B-Cell Activation;B-Lymphocytes;Biological Assay;Biological Phenomena;biological sex;Biology;Biomedical Research;cell age;Cells;Cellular Membrane;Cellular Metabolic Process;cellular targeting;Clinical Data;conditional knockout;Data;data modeling;design;Disease;Energy-Generating Resources;ESR1 gene;Estradiol;Estrogen Receptors;Estrogens;experimental study;Feedback;Female;follow-up;FRAP1 gene;Frequencies;Genus Hippocampus;Gonadal Steroid Hormones;hormone regulation;Human;human old age (65+);Humoral Immunities;Immune;immune activation;immune function;Immune response;Immunity;Immunofluorescence Immunologic;Immunoglobulin-Secreting Cells;Immunology;improved;Infection;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza vaccination;influenza virus vaccine;insight;Lipids;male;Measures;Mediating;Mediator;men;Metabolic;Metabolic Activation;Metabolic Pathway;metabolic profile;Metabolism;metabolomics;Mitochondria;Modeling;mouse model;Mus;neutralizing antibody;novel;Operative Surgical Procedures;oxidation;pandemic potential;pandemic virus;pathogens of pandemic potential;Pathway interactions;Ploidies;preference;Production;Proteins;Receptor Signaling;Regulation;reproductive;Research;Respiration;respiratory;Rest;Role;Serology;sex;Sex Chromosomes;Sex Differences;Signal Transduction;small molecule;Steroid Receptors;Stimulus;Testing;therapeutic target;Training;Transgenic Mice;translational applications;translational impact;Vaccinated;Vaccination;vaccination outcome;vaccine effectiveness;vaccine immunogenicity;vaccine-induced antibodies;vaccine-induced immunity;Vaccines;Viral;Viral Antibodies;Virus;Virus Diseases;Western Blotting;Woman;Women's Health

PROJECT_TITLE: mTOR activation as a mechanism for sex differences in vaccine-induced immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cancer;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Hematology;Immunotherapy;Infectious Diseases;Lung

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Sustained CD8 T cell function is required for the survival of patients with hematologic malignancies and severe lung infections. Our preliminary data demonstrates a role for Pellino-1 in mediating redox-dependent T cell dysfunction in cancer patients with severe COVID-19 infection. By understanding how Pellino-1 limits T cell function during persistent antigen exposure, the work in this proposal will reveal novel therapeutic targets to improve T-cell mediated control of respiratory infections, particularly in patients with hematologic cancers.

PI_NAMEs: MERLINSKY, TIFFANY REBECCA (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acetylcysteine;Acute;Adoptive Transfer;antigen-specific T cells;Antigens;Antioxidants;Biochemical;Cancer Patient;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Chronic;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;COVID-19 patient;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Defect;Disease;experience;Functional disorder;Genetic Recombination;Goals;Hematologic Neoplasms;high risk;Human;Humoral Immunities;Hypoxia;Immune;Immunity;Impairment;improved;In Vitro;in vivo;Infection;Influenza;innovation;insight;Knock-out;Laboratories;Laboratory Finding;Lead;Lung infections;Malignant Neoplasms;Measurable;Mediating;Metabolic;Mitochondria;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;Oxidation-Reduction;pathogen;Patients;Pneumonia;Post-Translational Protein Processing;posttranscriptional;prevent;Proteins;Proteome;Proteomics;Pseudomonas aeruginosa;Publishing;receptor;Regulation;Respiratory Tract Infections;Risk;Role;Sampling;SARS-CoV-2 infection;self-renewal;severe COVID-19;single cell genomics;Stress;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Time;Transcript;transcription factor;transcriptomics;Tumor Immunity;ubiquitin-protein ligase;Viral;Western Blotting;Work

PROJECT_TITLE: Investigating the redox-sensitive E3 ubiquitin ligase Pellino-1 as a driver of T-cell dysfunction during severe lung infection


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

PHR: PROJECT NARRATIVE The mitochondrial oxidative phosphorylation (OXPHOS) complexes, which are critical for ATP synthesis and for proper mitochondrial function, comprise subunits that are encoded by both the nuclear and the mitochondrial genomes. These two genomes must be co-regulated to ensure stoichiometric production of OXPHOS subunits, and to avoid mitonuclear imbalance, which can lead to mitochondrial disorders. This project will explore how diverse metabolism-related factors regulate the balanced expression of the two genomes for stoichiometric OXPHOS protein biogenesis, and uncover the link between metabolism and mitonuclear balance, identifying potentially novel therapeutic targets for mitochondrial disorders.

PI_NAMEs: RAICU, ANA-MARIA  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Affect;ATP Synthesis Pathway;Biogenesis;career;Cells;Citric Acid Cycle;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;complex IV;CRISPR screen;Cytosol;Development;Disease;Ensure;Equilibrium;Folic Acid;Functional disorder;Gene Expression;Gene Expression Regulation;gene-targeted therapy;Genes;Genetic Transcription;Genome;Growth;Health;Human;Individual;Inner mitochondrial membrane;Investigation;K562 Cells;Knock-out;Lead;Link;lipid metabolism;Maintenance;medical schools;Metabolic;Metabolic Control;Metabolism;Methionine;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;mitochondrial genome;mitochondrial therapeutics;Molecular;Nerve Degeneration;Neurologic;new therapeutic target;novel;Nuclear;Orphan;Oxidative Phosphorylation;Pathway interactions;Phosphorylation;Process;Production;programs;Protein Biosynthesis;Proteins;proteotoxicity;Pyrimidine Nucleotides;Reactive Oxygen Species;Regulation;Research;Respiration;Role;Scientist;Technology;Therapeutic;Training;Translations;Vitamin B 12;Work;Yeasts

PROJECT_TITLE: Metabolic control of mitonuclear balance for OXPHOS protein biogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


ADMINISTERING_IC: MH

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative  The objective of this proposal is to determine the genetic contributors to aging and sex differences on cognition and brain structure in a longitudinal cohort of middle-aged and older (MA+) autistic adults (40-75 years of age). We will evaluate the effects of autism risk genes on memory decline and temporal lobe/hippocampal aging in MA+ autistic adults. Results will significantly impact biological understanding of cognitive and brain aging with autism and sex differences in behavior as it incorporates both molecular and systems-level approaches.

PI_NAMEs: HARKER, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Acceleration;Address;Adolescent and Young Adult;Adult;adult with autism spectrum disorder;Advocacy;Age;age acceleration;age related;Age Years;Aging;aging brain;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Area;Arizona;autism community;Autism Diagnosis;autism spectrum disorder;autistic;Behavior;Biological;Brain;career;career development;Caring;Clinical;Cognition;Cognitive;Cognitive aging;cognitive function;cohort;Collaborations;Data;Development;Disproportionately impacts women;diversity and inclusion;dosage;empowerment;Endowment;Environment;Ethics;Exhibits;experience;Fellowship;Female;Funding;Genetic;Genetic Risk;Genomics;girls;Goals;high risk;Hippocampus;Impaired cognition;Individual;individuals with autism spectrum disorder;Institution;Knowledge;Laboratories;life span;Literature;long term memory;Longitudinal cohort;longitudinal design;male;Measures;Memory;Memory Loss;men;Mentors;Methods;middle age;Mission;Modeling;Molecular;neurogenomics;neuroimaging;Neurologic;Neuropsychology;Neurosciences;notch protein;novel;Outcome;Participant;Play;polygenic risk score;precision medicine;professor;Publications;Publishing;Quality of life;Research;Research Personnel;resilience;Risk;Risk Factors;risk variant;Role;serial imaging;sex;Sex Bias;Sex Differences;Short-Term Memory;skills;statistics;Stress;Structure;System;Temporal Lobe;tenure track;Thick;Thinness;Training;Translating;United States National Institutes of Health;Universities;verbal;Visual;Woman;Writing

PROJECT_TITLE: The Role of Autism Risk Genes in Cognitive and Brain Aging Outcomes of Autistic Adults


NIH_SPENDING_CATS: Dystonia;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative 1. PKR is a pattern recognition receptor which binds dsRNA, and that is overactivated in a variety of debilitating neurologic diseases (including Huntington’s disease, Alzheimer’s disease, and Aicardi-Goutières syndrome). 2. The G130R mutation in PKR leads to enhanced PKR activation both in patient fibroblasts with familial neurologic disease as well as in our cell culture system, but the mechanism of overactivation is not known. 3. This proposal will attempt to identify the cause of PKRG130R overactivation and its role in causing neurodegeneration, which may help identify strategies for future therapeutics for a range of different neurologic diseases where PKR is overactive.

PI_NAMEs: GERTIE, JAKE ANDERS (contact)

PROJECT_TERMS: 3' Untranslated Regions;Affect;Affinity;Alu Elements;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Arginine;Astrocytes;autoinflammatory;Binding;Binding Proteins;Biochemical;Biochemistry;Cardiac Myocytes;Cell Culture System;Cell Culture Techniques;Cell Differentiation process;cell type;Cells;crosslink;Development;Disease;DNA Transposable Elements;DNA-Directed RNA Polymerase;Double-Stranded RNA;Double-Stranded RNA Binding Domain;Doxycycline;Dystonia;early onset;EIF-2alpha;Event;Family;Fibroblasts;frontotemporal lobar dementia amyotrophic lateral sclerosis;Future;gain of function mutation;Genes;Genetic;Genetic Transcription;Genomics;Glycine;Goals;Hepatocyte;Hereditary Dystonia;Homodimerization;Human;human embryonic stem cell;Huntington Disease;Immune response;Immunologic Receptors;Immunoprecipitation;in vitro Assay;Individual;insight;Knock-in;Mass Spectrum Analysis;Messenger RNA;Microglia;mimetics;Molecular;Motion;Mus;Mutagenesis;mutant;Mutation;Nerve Degeneration;Nervous System;Nervous System Disorder;neural;Neurodegenerative Disorders;Neuroglia;Neurologic;neuron loss;Neurons;Nucleotides;pathogen;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern recognition receptor;Phosphorylation;Phosphotransferases;Play;Poly I-C;prevent;Property;Protein Binding Domain;protein expression;protein kinase R;protein protein interaction;Protein-Serine-Threonine Kinases;Proteins;pseudotoxoplasmosis syndrome;Reaction;Regulation;RNA;RNA Binding;Role;Sampling;sensor;Serine;Site;stem cell technology;Stimulus;Structure;System;targeted treatment;Testing;Therapeutic;tool;Transcript;Translation Initiation;Viral;Virus Diseases;Virus Replication

PROJECT_TITLE: Determining how a single-residue PKR mutation found in patients with familial dystonia causes aberrant PKR activation


NIH_SPENDING_CATS: Cancer

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Primary cilia are signal transducers important for development, cell polarization, and cell cycle control, and aberrant ciliation has been linked to developmental disorders and cancer. Cilia microtubules are highly glutamylated by the Tubulin Poly-glutamylation Complex, which interacts with TBC1D19, a protein with unknown function. Ablation of TBC1D19 in mammalian cells abrogates ciliation and alters Golgi morphology, prompting us to investigate whether these phenotypes are due to a role for TBC1D19 in promoting glutamylation or a potential function as a GTPase activating protein.

PI_NAMEs: COLLADO, LOREN  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Ablation;Affect;Binding;Biochemistry;Cell Cycle;Cell Cycle Regulation;Cell membrane;Cellular biology;Centrioles;Cilia;cilium biogenesis;Cilium Microtubule;Complex;Defect;Development;developmental disease;Disease;Docking;Enzymes;Event;experimental study;Family;Golgi Apparatus;Growth;GTPase-Activating Proteins;Guanosine Triphosphate;kinetosome;Knock-out;Laboratories;Ligase;Link;Lipids;Malignant Neoplasms;Mammalian Cell;Maps;Mediating;Membrane;Microscopy;Microtubule-Associated Proteins;Microtubules;migration;Modification;Molecular;Morphology;Mothers;Motor;novel;Organelles;Phenotype;polarized cell;Post-Translational Protein Processing;Process;protein function;Proteins;rab GTP-Binding Proteins;recruit;Regulation;Research;Role;Series;Shapes;SHH gene;Signal Pathway;Signal Transduction;Signaling Molecule;smoothened signaling pathway;Structure;Surface;Tertiary Protein Structure;Time;trafficking;Transducers;Tubular formation;Tubulin;tumorigenesis;Tyrosine;Vesicle;vesicle transport;WNT Signaling Pathway;Work

PROJECT_TITLE: Investigating the role of TBC1D19 in microtubule dynamics, ciliation and organelle morphology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Dissemination and Implementation Research;Mental Health;Mental Illness;Pediatric;Prevention;Suicide;Suicide Prevention

ORG_CITY: LUBBOCK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEXAS TECH UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Invalid assessments of suicidal thoughts and behaviors (STBs) have profound implications for development of suicide theories, research on suicide risk and protective factors, and clinical management, ultimately hampering suicide prevention, but extant research has documented wide discrepancies in reports of STBs across measures. This study will use qualitative and quantitative approaches to refine single-item STB measures, test their psychometric properties, and identify other factors impacting response accuracy in youth ages 15-24 with lived experience of STBs. Results of this study will provide actionable recommendations for brief assessment of STBs, improving management of risk and data collection accuracy for STBs assessed in research and clinical contexts.

PI_NAMEs: CHRISTENSEN, KIRSTEN  (contact)

PROJECT_TERMS: Adolescence;Adult;Age;Behavior assessment;Cause of Death;Clinical;Clinical Management;clinical practice;cognitive interview;Collaborations;Data;Data Collection;design;Development;Disclosure;Dissemination and Implementation;dissemination science;Educational workshop;Environmental Risk Factor;experience;Face;Feedback;Feeling suicidal;Fellowship;follow-up;Goals;ideation;implementation framework;implementation science;improved;Individual;Intervention;Interview;Knowledge;Literature;Lived experience;Measures;meetings;Mentors;Methods;Participant;Persons;Property;protective factors;Psychometrics;Qualitative Research;Recommendation;recruit;Reporting;Research;Research Activity;Research Design;Research Methodology;Respondent;response;Risk Assessment;Risk Factors;Risk Management;Sampling;Scientist;Screening procedure;Standardization;Structure;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide prevention;symposium;Testing;Texas;Theoretical Domains framework;theories;Thinking;Training;Training Activity;United States;Universities;Validation;Work;Youth

PROJECT_TITLE: Improving Brief Assessment of Suicidal Thoughts and Behaviors in Youth: An Engaged, Stakeholder-Informed Approach to Measure Development, Testing, and Implementation


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Liver Disease;Lung;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PROJECT NARRATIVE Proper salivary gland functioning is critical for oral health. Radiation therapy for head and neck cancer causes salivary gland fibrosis, thereby leading to hyposalivation. This proposal investigates the role of copper transport in radiation-induced fibrosis and loss of salivary gland function by testing novel therapeutic interventions that target copper metabolism.

PI_NAMEs: BAKER, OLGA JULIANA (contact);PETRIS, MICHAEL J.

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Affect;Agonist;American Cancer Society;antifibrotic treatment;AQP1 gene;Binding Sites;Biomedical Engineering;C10;cancer cell;Cancer Etiology;Catalytic Domain;Cell membrane;Cells;Chelating Agents;Chronic;Clinical;clinical application;Clinical Trials;clinically relevant;cofactor;Collagen;Computers;Connective Tissue;Copper;crosslink;Deposition;Disease;Drug Design;Enzymes;Event;Extracellular Matrix;Eye;Family;Family member;Fibrosis;Gene Silencing;gene therapy;Genetic study;Golgi Apparatus;Head and Neck Cancer;Heart;Homeostasis;idiopathic pulmonary fibrosis;In Vitro;in vivo;in vivo Model;Individual;inhibitor;Injections;Ionizing radiation;Kidney;Liver;Liver Fibrosis;Lung;member;Metabolism;metalloenzyme;Molecular;Monoclonal Antibodies;mouse model;Mus;novel;novel therapeutic intervention;Nuclear;Oral;Oral health;Oral mucous membrane structure;Organ;Parotid Gland;Pathologic;Patients;Persons;pharmacologic;Phase II Clinical Trials;primary sclerosing cholangitis;Process;Protein-Lysine 6-Oxidase;Radiation;Radiation Fibrosis;Radiation therapy;Rattus;Residual state;Role;Saliva;saliva secretion;Salivary Gland Tissue;Salivary Glands;side effect;Skin;standard care;Stem cell transplant;Submandibular gland;Testing;tetrathiomolybdate;Therapeutic;Therapeutic Effect;Tissues;trafficking;United States;Vesicle;Xerostomia

PROJECT_TITLE: Inhibition of Radiation-Induced Salivary Gland Fibrosis by Targeting Copper Metabolism


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Infectious Diseases;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE / RELEVANCE TO PUBLIC HEALTH The proposed research is relevant to public health because it focuses on developing novel alternative strategies to treat Cytomegalovirus (CMV) mediated hearing loss by investigating the role of fetal-derived resident tissue macrophages in normal cochlear development and during this intrauterine infection. Once such strategies have been developed, there is the potential for a significant advance in treating patients with CMV and possibly other types of hearing loss. Thus, the proposed research is relevant to NIDCD’s mission to conduct and support research in the normal and disordered processing of hearing, balance, taste, smell, voice, speech and language.

PI_NAMEs: BEAUDIN, ANNA E  (contact);PARK, ALBERT H;WELNER, ROBERT S

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Acute;acute infection;Adult;Affect;Architecture;Auditory;Auditory system;Automobile Driving;Biological Response Modifiers;Bone Marrow;Cells;Cochlea;cochlear development;congenital cytomegalovirus;congenital infection;CSF1R gene;Cytomegalovirus;Cytomegalovirus Infections;Data;defined contribution;Development;Disease;Equilibrium;fetal;Functional disorder;Genetic;Genetic Transcription;Goals;Growth;Health;Hearing;hearing impairment;hearing loss treatment;Hearing Tests;Histologic;Homeostasis;Immune;immune cell infiltrate;Immune response;Immunity;Impairment;improved;infant infection;Infection;Inflammation;innovation;intrauterine infection;Knowledge;Language;Life;Macrophage;Maps;Measures;Mediating;Mediator;Microscopy;Mission;Modeling;mouse model;Mus;National Institute on Deafness and Other Communication Disorders;Neonatal;new therapeutic target;novel;Pathogenesis;Pathogenicity;Patients;Pattern;perinatal development;Perinatal Infection;perinatal period;Physiological;postnatal;Predisposition;Public Health;Regulation;Research;Research Support;Resolution;response;Role;Sensorineural Hearing Loss;Shapes;Smell Perception;Source;spatiotemporal;Speech;Taste Perception;Testing;tissue injury;Tissues;transcriptomics;Virus Diseases;Voice;Work

PROJECT_TITLE: Cochlear resident tissue macrophages in normal cochlear development and the response to CMV infection

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Drivers are at risk for injury during crashes as they may sustain high accelerations that can cause concussion. This proposed study aims to quantify and characterize head acceleration events and evaluate brain tissue- level biomechanics during grassroots dirt track racing crashes while identifying potential factors that influence kinematic loads and tissue-level response; and assess the effects of head acceleration events on acute clinical outcomes. The combination of didactic coursework, experiential training, and mentorship from sponsors and collaborators will prepare the applicant for a career as an independent researcher utilizing a joint background in injury biomechanics and mechanical engineering towards improving motorsports safety.

PI_NAMEs: ZOCH, SOPHIA RUTH (contact)

PROJECT_TERMS: 18 year old;3-Dimensional;Acceleration;Acute;Adolescent;Anatomy;Area;Assessment tool;Australia;Biomechanics;Brain;Brain Concussion;Brain Injuries;Brain region;brain tissue;career;Categories;Cessation of life;Clinical;clinical diagnosis;clinical outcome assessment;contact sports;Craniocerebral Trauma;Custom;Data;Development;Diagnosis;Disparity;Elements;Engineering;Environment;Evaluation;Event;experience;Exposure to;Film;Frequencies;Future;Head;Head and neck structure;head impact;Helmet;Hobbies;Hospitalization;hospitalization rates;Hour;improved;Incidence;Injury;instrument;Intervention;Investigation;Joints;kinematics;Knowledge;Left;light weight;Location;Maintenance;Manufactured football;Measures;Mechanics;Mentors;Mentorship;Modeling;Motion;Neurocognitive;Neurologic Effect;Outcome;Participant;Pilot Projects;Race;Recording of previous events;Regulation;Reporting;Research;Research Personnel;Resolution;response;restraint;Retirement;Risk;Safety;Seasons;Seat Belts;sensor;Series;simulation;Soccer;Speed;Sports;Stress;subconcussion;success;System;Testing;Thick;Time;Tissues;Training;United States;Vehicle crash;Work

PROJECT_TITLE: Characterizing Head Impact Exposure, Tissue-level Brain Response, and Clinical Outcomes in Grassroots Dirt Track Racing


ORG_CITY: ANN ARBOR

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: No PHR

PI_NAMEs: KOUTMOU, KRISTIN S (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TERMS: Address;Adopted;analysis pipeline;Bacillus subtilis;base;Benchmarking;Biological;Cells;Chemicals;Collection;Communities;Data;data pipeline;Data Set;Detection;electric impedance;Enzymatic Biochemistry;Enzymes;falls;Follow-Up Studies;Frequencies;Gene Deletion;Genetic;Genomic approach;geographically distant;Goals;Human;In Vitro;Individual;Intention;interest;Knock-out;knockout gene;Learning;Length;Maps;Mass Spectrum Analysis;Measures;Messenger RNA;Methodology;Methods;Methyltransferase;Modification;mutant;nanopore;Nucleosides;Nucleotides;Oligonucleotides;Organism;parallelization;Planet Earth;Positioning Attribute;Protein Biosynthesis;Pseudouridine;Reporting;Research;Ribosomal RNA;RNA;RNA Sequences;Saccharomyces cerevisiae;Saccharomycetales;Sampling;sensor;sequencing platform;Signal Transduction;single molecule;Small Nucleolar RNA;synergism;Technology;theories;Time;tool;Transcriptional Regulation;transcriptome;Transfer RNA;Validation;Variant;Work;yeast genetics;Yeasts

PROJECT_TITLE: MFB: Integrating LC-MS/MS and Nanopore Sequencing Platforms to Enable the Direct and Quantatative Detection of RNA Modifications

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-P (J3)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Infectious Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHARLESTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Viral myocarditis is a common cardiac inflammatory disease that may rapidly progress to dilated cardiomyopathy, heart failure, and sudden cardiac death. The proposed studies aim to identify the role of the understudied cardiomyocyte-specific kinase TNNI3K in susceptibility to severe viral myocarditis. Completion of this project will provide new insights into the molecular mechanisms underlying viral myocarditis, with important implications for people carrying natural variants of TNNI3K and proposing targets for novel therapies to prevent progression to severe disease.

PI_NAMEs: TJEN, KELSEY  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Address;Affect;Aftercare;Award;Benign;Biological Assay;Cardiac;Cardiac Myocytes;Cell Line;Cells;clinically relevant;Congestive Heart Failure;Coxsackie Viruses;cytokine release syndrome;Data;Defect;Development;Diagnosis;Dilated Cardiomyopathy;Disease;Disease Progression;effective therapy;Etiology;experience;experimental study;Fellowship;Fibrosis;Frequencies;Future;Gene Expression;Genes;Goals;Heart;heart damage;Heart Diseases;Heart failure;heart function;Human;human induced pluripotent stem cells;immune cell infiltrate;In Vitro;in vivo;induced pluripotent stem cell derived cardiomyocytes;Infection;Inflammation;Inflammatory;insight;interest;Interferon alpha;Interferon Type I;Interferons;Knock-out;Knowledge;Link;Measures;Mediating;Methods;Modeling;Molecular;mouse model;Mouse Strains;Mus;mutant;Myocarditis;Myocardium;new therapeutic target;Pathogenicity;Pathway interactions;patient population;Patients;Persons;Phenotype;Phosphorylation;Phosphotransferases;Ploidies;Population;Predisposition;prevent;protein expression;Proteins;Public Health;Quantitative Trait Loci;Reporter;Research;Resistance;response;Response Elements;Role;Scientist;Signal Transduction;skills;sudden cardiac death;System;targeted treatment;Testing;Transfection;Troponin;Variant;Viral;viral myocarditis;Virus;Virus Diseases;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Cardiac troponin i3 kinase in viral myocarditis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (20)]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

PHR: Project Narrative The goal of this project is to understand how the electrical activity of retinal ganglion cells impacts their survival and function in glaucomatous injury. We will examine diverse retinal ganglion cell types in two models of experimental glaucoma to determine how their electrical activity is impacted by injury and if directly manipulating their activity can improve their survival. Overall the results of this study will inform future work targeted at maintaining and restoring functional vision in human retinal disease.

PI_NAMEs: DEMB, JONATHAN B (contact)

PROGRAM_OFFICER_NAME: HENLE, STEVEN JOHN

PROJECT_TERMS: Acute;Affect;Axon;axonal degeneration;Back;Blindness;Brain;Categories;Cell Death;cell injury;Cell Physiology;Cell Survival;cell type;Cells;cellular resilience;Chronic;Closure by clamp;designer receptors exclusively activated by designer drugs;Development;Electrophysiology (science);Experimental Models;experimental study;extracellular;Eye;Functional disorder;functional restoration;Future;Glaucoma;Goals;Health;Human;Impairment;improved;In Vitro;in vitro activity;in vivo;Individual;Injections;injured;Injury;Interneurons;Intervention;Kir2.1 channel;Light;Methods;Modeling;Morphology;mouse model;Mus;Nerve Crush;nerve injury;neural;Neural Retina;neuronal survival;Neurons;Optic Nerve;Optic Nerve Injuries;Output;patch clamp;Patients;Photoreceptors;Physiologic Intraocular Pressure;Physiological;Physiology;Population Heterogeneity;Potassium Channel;Predisposition;Preparation;resilience;response;Retina;Retinal Diseases;retinal ganglion cell degeneration;retinal ganglion cell regeneration;Retinal Ganglion Cells;Risk Factors;Role;Signal Transduction;Silicone Oils;Sodium Channel;Synapses;Testing;Time;Tissues;Vision;Visual impairment;visual processing;voltage;voltage clamp;Work

PROJECT_TITLE: Mechanisms of altered neuronal activity in experimental glaucoma


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Women's Health Research

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Adenosine-receptor stimulation by adenosine and structurally similar molecules including 5’methylthioadenosine has well-documented immunosuppressive properties in human solid tumors. It is hypothesized that enzymatic adenosine and 5’methylthioadenosine depletion with engineered human methylthioadenosine phosphorylase (hMTAP) can (a) offer a better therapeutic option in certain cancers when compared to the molecules already in clinical trials, and (b) offer further insight into the mechanism of action. This investigation will first increase hMTAPs slight affinity for adenosine to therapeutically relevant catalytic efficiency through methodical library design in order to test the effective depletion in vitro and in vivo, then focus on mechanistic evaluation by examining both the immune-independent influence of adenosine and its degradation products, and the balance of immunomodulatory mechanism of effector versus regulatory T cells.

PI_NAMEs: AL-KHALEDY, RANYA NOURA (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: 9p21;Active Sites;Adenine;Adenosine;Adenosine Triphosphate;Affect;Affinity;Agonist;Animal Model;anti-cancer therapeutic;Antibody Therapy;Biochemical;Biochemistry;Breast Cancer Cell;cancer cell;Cancer cell line;cancer immunotherapy;Cancer Model;cancer recurrence;cancer subtypes;Catabolism;CD8-Positive T-Lymphocytes;Cell model;Cell Proliferation;Cell Survival;Cells;Chemotherapy and/or radiation;Clinical Research;Clinical Trials;Codon Nucleotides;Colon Carcinoma;Coupled;CT26;CTLA4 gene;cytotoxic;Degradation Pathway;design;Development;dosage;Dose;draining lymph node;Effectiveness;efficacy evaluation;Engineering;Environment;Enzyme Stability;Enzymes;Equilibrium;Evaluation;Exhibits;experience;extracellular;Extracellular Fluid;Flow Cytometry;Gene Deletion;Growth;GTP-Binding Proteins;Human;Human Engineering;Hypoxia;Immune;Immune Evasion;immune function;Immunophenotyping;immunoregulation;Immunosuppression;Immunosuppressive Agents;In Vitro;in vivo;in vivo evaluation;Incubated;Individual;Inflammation;inhibitor;Inosine;insight;Investigation;Kinetics;Libraries;Ligands;Link;Lymphocyte;Malignant Neoplasms;MDA MB 231;Mediating;Melanoma Cell;Metabolic;Metabolic Pathway;migration;Modeling;Monitor;Monoclonal Antibody Therapy;Mus;mutation screening;NADP;Natural Killer Cells;Neoplasm Metastasis;novel;Pathway interactions;patient population;Patients;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Pharmacology Study;Phosphorylases;programmed cell death protein 1;Proliferating;Property;Proteomics;Purinergic P1 Receptors;Purines;Reaction;receptor;Regulatory T-Lymphocyte;Ribose;Serum;Solid Neoplasm;Stress;T cell differentiation;T-Cell Depletion;T-Lymphocyte;Testing;Therapeutic;Therapeutic Agents;Therapeutic Effect;therapeutic enzyme;therapeutic protein;therapeutic target;Tissues;Toxicology;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor immunology;tumor microenvironment;tumor progression;Work

PROJECT_TITLE: Enzyme-Mediated Depletion of Extracellular Adenosine and 5'methylthioadenosine as a Novel Anti-Cancer Therapeutic

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-Z (20)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE The increasing ability of bacteria to evade the effects of antibiotics is a significant global health crisis. This project will investigate how RNA modifying enzymes place their chemical modifications on a key bacterial antibiotic target (the ribosome) to alter antibiotic susceptibility and resistance. These studies will increase our understanding of how such RNA modifications influence the bacterial antibiotic response and could support future development of new therapeutic strategies to help counter the threat of bacterial antibiotic resistance.

PI_NAMEs: BARMADA, MOHAMED I (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Affect;Aminoglycoside resistance;Aminoglycosides;anti-microbial drug;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;Antimicrobial Resistance;Bacteria;Bacterial Antibiotic Resistance;bacterial resistance;base;Binding;Biological;Biological Assay;Bypass;Cessation of life;Chemicals;combat;Complement;Cryoelectron Microscopy;design;Development;Distant;Docking;Drug Binding Site;drug development;drug sensitivity;enzyme activity;enzyme mechanism;Enzymes;Escherichia coli;experimental study;Future;global health;Growth;Health;Housekeeping;Impairment;In Vitro;insight;Messenger RNA;Methylation;Methyltransferase;Microbiology;Modification;Molecular;molecular dynamics;Multi-Drug Resistance;Mutagenesis;novel;novel therapeutic intervention;Pharmaceutical Preparations;Play;Positioning Attribute;Predisposition;Process;Public Health;Research Personnel;Resistance;resistant strain;Resolution;response;Ribose;Ribosomal RNA;Ribosomes;RNA;Role;Scientist;Series;Site;Structure;Surface;Testing;Time;Training;Work

PROJECT_TITLE: Intrinsic Ribosomal Decoding Center Methylation and the Bacterial Antibiotic Response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04B-S (20)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative: Exposure to air pollution, particularly particulates, is a prime risk factor for the development of neurodegenerative disease. This project will utilize histological and advanced imaging techniques to investigate how nanoplastic particles can enter the central nervous system, where they localize in the brain, and what factors influence their uptake.

PI_NAMEs: GREENAWALT, DENVER  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Ablation;Acute;Affect;Age;Air;Air Pollutants;Air Pollution;Alzheimer's disease related dementia;Alzheimer's disease risk;Amygdaloid structure;Anatomy;Antibodies;apolipoprotein E-3;apolipoprotein E-4;Apolipoproteins;Brain;brain pathway;career;cell type;Cells;Central Nervous System;Cephalic;Cessation of life;Chemicals;Communication;Confocal Microscopy;cribriform plate;Data;dentate gyrus;Development;Endocytosis;experimental study;exposure route;Exposure to;Faculty;genetic risk factor;Genotype;glial activation;Goals;Health;Histologic;Histological Techniques;Hour;Image;imaging approach;Imaging Techniques;Impaired cognition;Implant;In Vitro;in vivo;Inflammation;Inflammatory Response;Inhalation;Intranasal Administration;Investigation;Link;Lipopolysaccharides;Mentorship;Microglia;Modernization;Monitor;Mus;nanoparticle;Nasal cavity;Nasal Epithelium;Nervous System Disorder;Neuroanatomy;Neurodegenerative Disorders;Neurons;Nose;olfactory bulb;olfactory sensory neurons;outcome prediction;Parahippocampal Gyrus;particle;Particulate;Particulate Matter;Pathway interactions;Plastics;pollutant;Polystyrenes;Population;Positioning Attribute;Predisposition;Process;Research;Research Methodology;response;Risk;Risk Factors;Route;Saline;Sampling;sex;skills;Stains;Statistical Data Interpretation;Subcellular Anatomy;trafficking;Training;transmission process;Travel;two photon microscopy;two-photon;undergraduate student;Universities;uptake;Work;Zinc Sulfate

PROJECT_TITLE: Nasal uptake of polystyrene nanoplastics into the murine central nervous system


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: LIEBER INSTITUTE, INC.

PHR: Project Narrative Investigating the synaptic deficits associated with TCF4 loss-of-function (LOF) in Pitt-Hopkins Syndrome (PTHS) holds significant public health relevance as autism spectrum disorders (ASDs) affect approximately 1 in 100 individuals globally. Despite the prevalence of ASDs, there is a lack of targeted therapeutic interventions, particularly addressing presynaptic contributions to the pathology. Understanding the molecular mechanisms underlying TCF4 dysfunction and the potential therapeutic impact of RIMBP2 re-expression could provide insights into novel treatment approaches for ASDs, addressing a critical gap in current therapeutic options for this complex neurodevelopmental condition.

PI_NAMEs: PATEL, CHINTAN R (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Address;Adult;adult with autism spectrum disorder;Affect;Architecture;autism spectrum disorder;autosomal dominant mutation;Behavioral;behavioral phenotyping;BHLH Protein;Calcium;Calcium Channel;Candidate Disease Gene;candidate identification;career;Chelating Agents;Complex;Coupling;Data;Defect;density;Development;differential expression;Disease;Docking;Down-Regulation;Education;Electric Stimulation;Electron Microscopy;Employment;Environment;Event;Exhibits;experience;experimental study;Foundations;Frequencies;Functional disorder;Future;Gene Expression Profiling;Genes;Genetic;Genetic Diseases;Glutamates;Gold;Human;human model;Imaging Techniques;Impairment;Independent Living;Individual;innovation;insight;interest;Label;Life;Link;live cell imaging;loss of function;loss of function mutation;Measures;Mediating;Mentorship;Methodology;migration;Modeling;Molecular;Morphology;mouse model;Mus;Mutant Strains Mice;Mutation;nanoscale;Nature;neurodevelopment;Neurodevelopmental Disorder;Neurons;Neurosciences Research;neurotransmitter release;novel;novel strategies;Oligodendroglia;Outcome;Pathology;patient derived induced pluripotent stem cells;Patients;peer;PF4 Gene;Phenotype;Physiological;Pitt-Hopkins syndrome;Population;Positioning Attribute;postsynaptic;presynaptic;Prevalence;Probability;Proteins;public health relevance;Publishing;Quantitative Microscopy;repetitive behavior;Research;Research Activity;Role;Scaffolding Protein;sensor;Site;Social Interaction;stem;superresolution microscopy;Synapses;Synaptic Transmission;Synaptic Vesicles;synaptogenesis;targeted treatment;Therapeutic;Therapeutic Intervention;Time;time use;Tissue-Specific Gene Expression;Training;Training Activity;transcription factor;transcriptome sequencing;transmission process;Vesicle;voltage

PROJECT_TITLE: Investigating TCF4 and Synaptic Dysfunction in Pitt-Hopkins Syndrome


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative: Black breast cancer survivors with obesity are at an increased risk of poorer cancer-related outcomes, additional multimorbid conditions, and worse survival/greater mortality. This innovative multi-method study will identify protective and risk factors needed to tailor evidence-based weight loss interventions to address the unique challenges of Black breast cancer survivors – which will contribute to vital scientific and public health knowledge regarding intervention design for a population at high risk. Further, this project will serve as a valuable training opportunity for a young scholar to gain expertise in multimorbidity among underserved populations and how to adapt interventions targeting multimorbidity to advance equitable cancer care and treatment.

PI_NAMEs: SINCLAIR, KELSEY L (contact)

PROJECT_TERMS: Address;Aftercare;Award;Back;Behavioral;Behavioral Medicine;biopsychosocial;black patient;Black Populations;Black race;black women;Body Weight decreased;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer survivor;cancer care;Cancer Death Rates;cancer diagnosis;Cancer Etiology;Cancer Survivorship;cancer therapy;Cardiometabolic Disease;Caring;Cessation of life;Chronic;Chronic Disease;Collaborations;Communities;comorbidity;Complex;Dangerousness;Data;Data Collection;Death Rate;design;Development;Disease;Disparity;Equity;Ethnic Origin;Ethnic Population;Evaluation;evidence base;experience;factor A;fighting;Foundations;Funding;Future;global health;Goals;Health;health disparity;health knowledge;healthy lifestyle;Heterogeneity;high risk;implementation intervention;Incidence;individualized medicine;Inequity;Infrastructure;innovation;Intervention;Interview;Learning;lens;Life;Link;Literature;Long-Term Care;Malignant Breast Neoplasm;Malignant Neoplasms;Medicine;Mentorship;Methodology;Methods;Minority Groups;Modification;mortality;multiple chronic conditions;neglect;Newly Diagnosed;Obesity;obesity treatment;Outcome;Parents;Participant;Patient Care;Patients;peer;Phase;pilot trial;Population;Populations at Risk;protective factors;Protocols documentation;Public Health;Publishing;Qualitative Methods;Race;racial population;recruit;Reporting;Research;Research Personnel;research study;Research Training;Resources;response;Risk;Risk Factors;Sampling;Science;Scientist;Screening for cancer;skills;social stigma;socioeconomics;statistical learning;Statistical Methods;Structure;Subgroup;Surveys;survivorship;systematic review;Testing;therapy design;Training;training opportunity;treatment disparity;treatment effect;treatment response;Treatment Side Effects;Underserved Population;Voice;Weight;Weight Gain;weight loss intervention;weight loss program;Woman

PROJECT_TITLE: Factors Impacting Global Health: The Importance of Individualized Treatment Goals for Black Breast Cancer Survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (21)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Lymphatic Research;Rare Diseases

ORG_NAME: YALE UNIVERSITY

PHR: NARRATIVE  Cholestasis is a clinical syndrome with the accumulation of bile acids in the liver, thereby resulting in severe liver injury, fibrosis, biliary cirrhosis and ultimately end-stage liver disease. There is an urgent unmet medical need for new treatments for these diseases. The goal of this study is to understand the role of the hepatic lymphatic system in the pathogenesis of cholestatic liver diseases and explore its potential as a therapeutic target for these diseases.

PI_NAMEs: IWAKIRI, YASUKO  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acids;Affinity;Animals;Antigens;Autoimmune;Bile Acids;bile duct;Bile fluid;Biliary cirrhosis;Bilirubin;Cell Physiology;Cell Proliferation;Cells;cholangiocyte;Cholestasis;Clinical;Development;Disease;end stage liver disease;experimental study;Fibrosis;G-Protein-Coupled Receptors;gain of function;Genetic Transcription;Goals;healing;Hepatic;Hepatic artery;Hepatic Stellate Cell;Hepatocyte;Hydrophobicity;Immune;In Vitro;in vivo;Inflammation;Inflammatory;Injury;Knock-out;Ligation;Liver;Liver diseases;Liver Fibrosis;liver injury;loss of function;Lymph;lymph nodes;Lymphangiogenesis;Lymphatic;lymphatic drainage;Lymphatic Endothelial Cells;Lymphatic System;lymphatic vessel;Medical;Modeling;Molecular;mouse model;Mus;novel;novel therapeutics;overexpression;particle;Pathogenesis;Patients;Plasma;Population;Portal vein structure;Primary biliary cirrhosis;primary sclerosing cholangitis;Process;Proliferating;receptor;Regulation;response;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Specimen;Syndrome;Taurodeoxycholic Acid;Testing;Therapeutic;therapeutic target;Time;Vascular Endothelial Growth Factor C;Viral;wasting;Work

PROJECT_TITLE: The role of lymphatics in cholestatic liver disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-F (02)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Genetics;Neurosciences;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative Obesity is a chronic disease with broad health consequences, complex genetic and environmental causes, and increasing prevalence, all despite extensive public health efforts to reduce its impact. This research will evaluate how genetic variation related to the function of GLP-1 may explain variation in appetitive traits and conditioned responses to food cues among pre-adolescent children, and how these characteristics may lead to or prevent weight gain in pre-adolescence. Knowledge gained on the role of GLP-1 in pre-adolescent eating behaviors and weight gain may ultimately lead to enhanced obesity prevention and treatment efforts.

PI_NAMEs: RENIER, TIMOTHY J (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Adult;aged;Agonist;Appetite Regulation;Area;Automobile Driving;Behavior;Behavioral;Body mass index;Body Weight Changes;Brain;brain reward regions;career;Characteristics;Child;Chronic Disease;clinical application;collaborative environment;college;comorbidity;Complex;Conditioned Reflex;Consumption;cue reactivity;Cues;Data;Data Analyses;Data Set;Desire for food;Eating;Eating Behavior;Environmental Risk Factor;Enzymes;Etiology;Excess Mortality;Exposure to;Food;food environment;Functional disorder;Functional Magnetic Resonance Imaging;Gastric Emptying;Genetic;Genetic Predisposition to Disease;genetic risk factor;genetic variant;Genetic Variation;genome wide association study;Genotype;GLP-I receptor;glucagon-like peptide 1;Goals;Health;Height;Heterogeneity;high dimensionality;Hunger;Incidence;incretin hormone;Individual;insulin secretion;Knowledge;Life;Link;Measurement;Mediating;Mediation;Mediator;Medical;Methods;Morbid Obesity;neural;neuroimaging;novel;Obesity;obesity genetics;obesity in children;obesity prevention;obesity risk;obesity treatment;obesogenic;Parents;Pathway interactions;Pharmaceutical Preparations;Phenotype;Physicians;Plasma;Play;polygenic risk score;preadolescence;Predisposition;Preparation;Prevalence;prevent;programs;Prohormone Convertase;prospective;Public Health;Questionnaires;receptor;Regulation;Reporting;Research;Resistance;response;Rewards;Role;Sampling;Satiation;Science;Scientist;Single Nucleotide Polymorphism;skills;Statistical Methods;theories;Therapeutic;Training;trait;Variant;Weight;Weight Gain;Weights and Measures

PROJECT_TITLE: Associations of GLP-1-related genotypes with appetitive traits, food cue reactivity, and prospective weight gain in pre-adolescence

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE The epithelial lining of the gastrointestinal tract is completely replaced about once a week, making it one of the most rapidly cycling tissues in the human body. Our goal is to understand how two developmental growth pathways get rewired to support stem cell-based renewal in the rapidly cycling intestines. The powerful model system Drosophila melanogaster will be used to further our understanding of the highly conserved mechanisms that regulate intestinal tissue renewal.

PI_NAMEs: PLACENTRA, VICTORIA  (contact)

PROJECT_TERMS: Acute;Adult;Alleles;Amino Acids;Antibodies;ATAC-seq;Automobile Driving;Binding;Biological Models;Candidate Disease Gene;Cell Count;Cell Death;cell injury;Cell Proliferation;Cell Separation;cell type;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Colorectal Cancer;colorectal cancer progression;comparison control;Complex;Cues;Data;Daughter;Development;differential expression;DNA Binding;Drosophila genus;Drosophila melanogaster;Ecdysone;ecdysone receptor;Enterocytes;Enteroendocrine Cell;Epithelium;Fertility;fly;gastrointestinal epithelium;Gastrointestinal tract structure;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;Genome;Genotype;Goals;Green Fluorescent Proteins;Growth;gut homeostasis;Heterozygote;Histone H3;Homeostasis;Homologous Gene;Homozygote;Hormones;Human;Human body;Impairment;in vivo;injured;Injury;insight;intestinal epithelium;intestinal homeostasis;intestinal injury;Intestines;Label;LacZ Genes;Literature;Maps;Midgut;Mitotic;Mitotic Activity;Modeling;Monitor;Mus;mutant;NCOA3 gene;Nuclear;Nuclear Hormone Receptors;Nuclear Receptors;Organ Size;Orthologous Gene;overexpression;Pathway interactions;Physiologic pulse;Polysaccharides;Population;Process;progenitor;programs;Proline;promoter;Protein-Serine-Threonine Kinases;Proteins;Quantitative Reverse Transcriptase PCR;Receptor Signaling;response;RNA Interference;Role;Sampling;Serine;Signal Pathway;Sodium Dextran Sulfate;stem cell biomarkers;stem cell division;Stem Cell Factor;stem cell proliferation;stem cells;steroid hormone;Sulfate;System;Testing;Time;tissue regeneration;Tissues;tool;Transcription Coactivator;Transcriptional Regulation;transcriptome sequencing;Tryptophan;Tyrosine;Wing

PROJECT_TITLE: Homeostatic control of intestinal stem cell renewal by two transcriptional coactivators


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PHR: Project Narrative Kaposi’s sarcoma-associated herpesvirus (KSHV) depends on ORF68, an essential accessory factor of unknown function, to package its viral genome into capsids. A recent high-resolution structure revealed that ORF68 adopts a novel fold and oligomerizes into a pentameric ring; despite this advance, the mechanistic role of ORF68 in packaging remains unknown, which must be addressed to enable rational drug design. Here, I will use structural approaches in concert with a viral replication cell model to establish a critical link between in vitro observations with molecular function in vivo.

PI_NAMEs: GELLES-WATNICK, SARA  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Ablation;Address;Adopted;Affinity;aged;Bacteriophages;Binding;Biological Assay;biophysical analysis;black men;Cancer Etiology;cancer type;Capsid;Cell model;Cell Nucleus;Cells;Cessation of life;Complex;Cryoelectron Microscopy;Data;Disease;DNA;DNA Binding;Double Stranded DNA Virus;Drug Design;ds-DNA;Event;Future;Genome;Herpesviridae;Herpesviridae Infections;high risk;HIV;HIV-1;Homologous Gene;Human;Human Herpesvirus 4;Human Herpesvirus 8;In Vitro;in vivo;Infection;Insecta;insight;Kaposi Sarcoma;Knowledge;Link;Lytic;Modeling;Molecular;monomer;Motor;Mozambique;Multicentric Angiofollicular Lymphoid Hyperplasia;Mutation;Nature;novel;novel therapeutics;overexpression;Patients;Prevalence;prevent;primary effusion lymphoma;Process;Production;protein purification;Proteins;Recombinants;Resolution;Role;standard care;stoichiometry;Structure;Testing;therapeutic target;Uganda;United States;Viral;Viral Genome;Viral Packaging;Virion;Virus;Virus Diseases;Virus Replication;Visual;Work

PROJECT_TITLE: Elucidating the molecular function of Kaposi's sarcoma-associated herpesvirus packaging accessory protein ORF68


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Sleep Research;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE  Some individuals who binge drink are more likely than others to experience alcohol-related blackouts, and this individual blackout risk is not fully predicted by behavioral or pharmacological factors (e.g., body weight, rate of drinking, mode of consumption). People who report experiencing blackouts are at an increased risk of harms related to drinking, including physical injury and death. We hypothesize that there may be specific patterns of brain activity that make some individuals susceptible to alcohol-related blackout; identifying these biological risk factors would provide the foundation for targeted clinical interventions for those most at risk of serious injury resulting from alcohol use.

PI_NAMEs: ELLIOTT, GRACE MAE (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Adult;Alcohol consumption;alcohol exposure;alcohol misuse;alcohol response;alcohol use disorder;Alcoholic Intoxication;Alcohols;Amnesia;Arousal;awake;Behavior;behavior prediction;Behavioral;behavioral disinhibition;binge drinking;Biological;Blood alcohol level measurement;Body Composition;Body Weight;Brain;Categories;Cessation of life;Characteristics;Classification;Clinical;comparative efficacy;comparison control;Conscious;Consumption;Data;Development;Diagnostic;diagnostic criteria;Disease;Disinhibition;Dissociation;drinking;drinking behavior;Electrodes;Electroencephalography;Equilibrium;Event;Evoked Potentials;Exhibits;experience;Faculty;Failure;Feeling;Foundations;Frequencies;Functional disorder;gamma-Aminobutyric Acid;Gastric Emptying;Genetic Predisposition to Disease;Heritability;Hippocampus;Human;Image;Impairment;Individual;individual variation;Injury;Interneurons;Intervention;Intoxication;Life;Literature;long term memory;Maintenance;Measures;Mediating;Modeling;Motor;Motor Activity;motor control;Motor Cortex;motor impairment;neural patterning;Neurobiology;neurophysiology;non rapid eye movement;Parasomnias;Patient Self-Report;Patients;Pattern;Persons;pharmacologic;Phenotype;Physiologic pulse;pre-clinical;Predisposition;Prevalence;Proxy;psychologic;Recording of previous events;Regulation;Reporting;resilience;Rest;Risk;Risk Factors;Role;Severities;Short-Term Memory;Site;Sleep;Slow-Wave Sleep;sobriety;social;Somnambulism;Transcranial magnetic stimulation;Work;Youth

PROJECT_TITLE: Identifying the Neurophysiological Phenotypes that Contribute to Alcohol-Related Blackout Susceptibility

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Neurosciences;Nutrition;Obesity;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: PSYCHIATRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Food cravings are highly salient and prevalent events that contribute to overconsumption, and for some individuals, food addiction, obesity, and other health sequelae. Here, combining neuroeconomic behavioral models with neuroimaging, I will elucidate the brain mechanisms linking craving to subjective value computations that promote the pursuit of highly palatable foods, and assess how this cognitive process may be altered in individuals with addictive food consumption (food addiction). Results from this work will clarify how craving exerts its effects at the neural level in food addiction, and behavioral addictions more broadly, which could inform future interventions aimed at combating craving-associated overconsumption behavior.

PI_NAMEs: SCHWEITZER, EMMA  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: addiction;Address;base;Behavior;Behavioral;Behavioral Mechanisms;Behavioral Model;behavioral study;Brain;Brain region;Calories;Categories;Classification;Clinical;cognitive process;comparison control;Competence;Consumption;craving;cue reactivity;Cues;Decision Making;Development;Diabetes Mellitus;Diffuse;Dimensions;Drug Addiction;drug craving;editorial;Emotions;Event;Exhibits;experience;Fatty acid glycerol esters;Food;food addiction;food consumption;food craving;Functional Magnetic Resonance Imaging;Future;General Population;Health;Heart Diseases;Hyperphagia;improved;indexing;Individual;insight;instrument;Intervention;Knowledge;Link;Malignant Neoplasms;Methods;Motivation;multisensory;neural;neural circuit;neural patterning;Neurobiology;neuroeconomics;neuroimaging;neuromechanism;Neurosciences;non-drug;novel;Obesity;Obesity Epidemic;Overweight;Pattern;Persons;Pharmaceutical Preparations;pre-doctoral;Prefrontal Cortex;Process;Public Health;Reporting;Research;Role;Route;Satiation;Savory;skills;Surveys;Testing;theories;Time;Training;Translating;translational scientist;Ventral Striatum;Weight;Weight Gain;willingness to pay;Work;World Health Organization

PROJECT_TITLE: Craving's role in biasing subjective value computation in food addiction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE Clostridioides difficile is the leading cause of nosocomial-associated diarrhea worldwide and is responsible for ~13,000 deaths each year in the US alone. C. difficile spore germination is essential for this obligate anaerobe to transform into its vegetative form, which releases toxins and cause disease. Elucidating the molecular details of this essential process may inform strategies for preventing C. difficile infection.

PI_NAMEs: MCNELLIS, MORGAN  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Affect;Amino Acids;Amino Sugars;Anaerobic Bacteria;Bacteria;Bile Acids;Binding;Biochemical;biophysical analysis;Cell Physiology;Cells;Cessation of life;Clostridium difficile;Complex;Cytology;Data;Diarrhea;Disease;Divalent Cations;Elements;Event;Family;Genetic;genetic analysis;Germination;Heterodimerization;Homodimerization;Hydration status;In Vitro;Infection;insight;Investigation;Life;LytA enzyme;Mediating;Medical;Membrane;Metabolic;Methods;Modeling;Molecular;monomer;Mutate;Mutation;Nutrient;pathogen;Peptide Hydrolases;Peptidoglycan;Play;predictive modeling;prevent;Process;Proteins;receptor;Regulation;Reproduction spores;response;Signal Induction;Signal Transduction;Signaling Molecule;small molecule;Structure;Testing;therapeutic development;Thick;Toxin

PROJECT_TITLE: Pseudoprotease-mediated regulation of germinant sensing in Clostridioides difficile

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Teenage Pregnancy;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: Chicago

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Elucidating the individual, social, and cultural factors that contribute to South African adolescent girls' and young women's (SAAGYW) sexual risk behavior is essential for informing evidence-based HIV and STI prevention interventions. The proposed mixed methods study will provide a multifaceted exploration of the association between mental health distress and SAAGYW sexual risk behavior, and the effects of intimate partner violence and female caregiver warmth and communication on this association. Findings from this study will inform research programs focused on addressing the effects of mental health distress, intimate partner violence, and prevention of HIV and STI among South African adolescent girls and young women by including female caregivers as resources of prevention support.

PI_NAMEs: DEBRA, ALYSSA  (contact)

PROGRAM_OFFICER_NAME: LEE, SONIA S

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;affection;Age;AIDS prevention;Anxiety;Applied Skills;Behavioral;career;Caregivers;Collaborations;Communication;condoms;Country;Data;Data Analyses;depressive symptoms;Disproportionately impacts women;Distress;Doctor of Philosophy;Education;emotional abuse;empowerment;Enrollment;Ensure;Epidemiology;evidence base;experience;Exposure to;Fellowship;Female;Female Adolescents;follow-up;Frequencies;global health;Goals;high risk sexual behavior;HIV;HIV Infections;HIV risk;improved;Individual;infection risk;insight;International;Intervention;Interview;intimate partner violence;Investigation;Journals;Knowledge;Learning Skill;Link;Medical;men;Mental Depression;Mental Health;Mentorship;Methods;Parents;Participant;Partner Communications;Persons;Physicians;Preparation;Prevalence;Prevention;Prevention strategy;preventive intervention;programs;Publishing;Qualitative Methods;Qualitative Research;Randomized, Controlled Trials;Recording of previous events;recruit;Reporting;Research;Research Methodology;research study;Resources;Risk;Role;Safe Sex;Sampling;Scientist;secondary analysis;self-reported depression;sex;sexual and reproductive health;sexual debut;Sexual Partners;sexual risk behavior;sexual risk taking;Sexually Transmitted Diseases;skills;social;South Africa;South African;STI prevention;success;Surveys;symposium;Training;Training Activity;Trauma;traumatic stress;violence exposure;Woman;young woman

PROJECT_TITLE: Investigation of Social and Behavioral Drivers of HIV Risk Among South African Adolescent Girls and Young Women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17B-K (20)]