NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PI_NAMEs: FUEMMELER, BERNARD F (contact)

PROJECT_TERMS: Accounting;Address;Advanced Malignant Neoplasm;Advisory Committees;Award;Budgets;Cancer Control;cancer prevention;career;Charge;Collaborations;Communication;Communities;community engagement;dashboard;data management;Databases;Development;Dissemination and Implementation;Doctor of Philosophy;Ensure;Equity;Ethics;Evaluation;experience;Family;Goals;Health;health equity;Housing;improved;Income;Individual;Institution;interest;Intervention;Investments;Knowledge;Lead;Leadership;Malignant Neoplasms;Measures;meetings;Mentors;Methodology;Methods;Monitor;National Cancer Institute;operation;Outcome;Peer Review;Persons;Postdoctoral Fellow;pre-doctoral;Prevention Research;prevention service;Principal Investigator;Process;Progress Reports;Public Housing;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;Services;skills;social;symposium;Training;U.S. Department of Housing and Urban Development;Virginia

PROJECT_TITLE: The Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (VA-ACCERT) Center


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Prevention;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PI_NAMEs: KRIST, ALEXANDER H (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;anti-cancer research;Cancer Control;Cancer health equity;cancer prevention;career;clinical center;Clinical Research;Collaborations;Communities;community engagement;community engagement process;community partners;Comprehensive Cancer Center;Computer software;Consultations;contextual factors;cost effective;Data;data access;Data Analyses;Data Collection;data management;data sharing;Decision Making;design;Development;Dissemination and Implementation;doctoral student;Ensure;Equity;Ethics;Evaluation;experience;Faculty;Family;Funding;Future;Goals;Health;Health Promotion;Housing;improved;Income;Individual;Information Dissemination;Infrastructure;Intervention;Knowledge;lens;marginalized community;Measures;medical schools;Mentors;Methodology;Methods;Mission;National Cancer Institute;Outcome;Ownership;Pilot Projects;Postdoctoral Fellow;pre-doctoral;prevention service;Process;Qualitative Methods;Recording of previous events;Relationship-Building;Reporting;Reproducibility;Research;Research Methodology;Research Personnel;Research Project Grants;Resource Sharing;Resources;Science;Services;social;System;Training;Translating;Translational Research;Trust;United States National Institutes of Health;Universities;Virginia

PROJECT_TITLE: The Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (ACCERT) Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-F (M1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Physical Activity;Prevention;Social Determinants of Health

PI_NAMEs: ARCAN, CHRISA  (contact)

PROJECT_TERMS: Accelerometer;Adult;Advanced Malignant Neoplasm;authority;behavior change;built environment;Cancer Control;cancer health disparity;cancer risk;Characteristics;Clinical;Clinical effectiveness;clinical implementation;cohesion;Communities;community advisory board;community based participatory research;community intervention;Crime;Data;design;Diet;digital;Disparity;Dose;economic disparity;Effectiveness;Effectiveness of Interventions;effectiveness outcome;Enrollment;Environment;Equity;evidence base;Family;Feedback;Goals;Health;Health Food;Healthy Eating;High Prevalence;Household;Housing;hybrid type 2 trial;implementation evaluation;implementation/effectiveness;improved;Income;indexing;Individual;Intervention;Interview;Life Style;lifestyle factors;lifestyle intervention;Maintenance;Malignant Neoplasms;meetings;Methods;Modeling;moderate-to-vigorous physical activity;neighborhood association;Neighborhoods;Obesity;Outcome;Participant;Pathway interactions;Phase;Physical activity;physical inactivity;Play;Poverty;Process;Public Health;Public Housing;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;Reporting;Research;Research Personnel;Research Project Grants;Resources;Risk Factors;Role;satisfaction;social;social cohesion;sociodemographics;Surveys;Testing;tool;Translating;trial design;Virginia;Well in self;Work


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

PI_NAMEs: SHEEHAN, BRYNN  (contact)

PROJECT_TERMS: acceptability and feasibility;Adult;Advanced Malignant Neoplasm;Age;arm;Articulation;Awareness;Behavioral Model;Cancer Control;Cancer Etiology;cancer prevention;career;Cessation of life;cohesion;Colon;colon cancer screening;Colorectal Cancer;colorectal cancer screening;Communities;community advisory board;community engaged research;cost efficient;Data;data management;design;Development;Dissemination and Implementation;efficacy testing;Eligibility Determination;Equity;ethnic minority population;Evaluation;Family;feasibility testing;Feedback;Focus Groups;Funding;Funding Opportunities;Goals;Health;health equity;health literacy;Health Promotion;Housing;improved;Income;Individual;informant;Intervention;Interview;Leadership;Letters;low socioeconomic status;Malignant Neoplasms;marginalized population;Measures;Mediator;meetings;member;Mentors;Monitor;multiple data sources;Outcome;Participant;peer;Peer Review;Personal Communication;post intervention;Postdoctoral Fellow;pre-doctoral;prevention service;Process;programs;Public Housing;Qualitative Methods;racial minority population;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Research Support;satisfaction;screening;Services;social;success;symposium;Testing;therapy development;Training;trial design;U.S. Department of Housing and Urban Development;United States;United States National Institutes of Health;uptake;Virginia


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: TSRL, INC.

ORG_STATE: MI

PHR: Project Narrative TSRL is developing a novel transdermal delivery product of zanamivir for the treatment and prevention of the flu. The proposed research plan will permit the planning, design, and preparation of all the documents necessary for the Phase I Clinical Trial, as well as its ultimate conduct.

PI_NAMEs: LIPKA, ELKE  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Acute;Adamantane;Address;Adhesions;Adverse effects;Agreement;Blood specimen;Budgets;Case Report Form;Cessation of life;Characteristics;Circulation;Clinical;clinical development;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Collection;Communication;Communities;Consent Forms;Data;Data Analyses;data management;Data Reporting;data sharing;Dermal;design;Development;Devices;Disease Outbreaks;Dose;drug development;Drug Kinetics;Effectiveness;Elderly;endonuclease;Ensure;Epidemic;Epithelium;Evaluation;Excision;Formulation;Funding;Goals;Grant;healthy volunteer;Hour;Human;Hydrogels;improved;Influenza;influenza epidemic;influenza outbreak;Influenza prevention;influenza virus strain;influenzavirus;Informed Consent;Inhalation;inhibitor;Liquid substance;Literature;Lung;Manuals;manufacture;Marketing;Medical;meetings;Methods;Miniature Swine;Modeling;Monitor;mortality;Needles;Neuraminidase inhibitor;novel;novel therapeutics;open label;operation;Oral;Oseltamivir;Painless;Pamphlets;pandemic disease;pandemic influenza;participant enrollment;patient population;Patients;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Phase;Phase I Clinical Trials;Plasma;Population;Powder dose form;pre-clinical;Preparation;prevent;Process;product development;Publishing;Rattus;Research;research clinical testing;Research Personnel;Residual state;Resistance;resistant strain;respiratory;Respiratory System;Role;Route;Safety;safety assessment;Sampling;seasonal influenza;Seasons;Secure;Site;Skin;skin barrier;skin irritation;Small Business Innovation Research Grant;Specialist;Statistical Data Interpretation;success;Surface;Syringes;System;Therapeutic;Toxicology;Transdermal substance administration;transmission process;trial planning;Urine;Vaccines;Visit;Wood material;zanamivir

PROJECT_TITLE: Phase 1 Clinical Trial to Assess the Pharmacokinetics, Safety and Tolerance of a Zanamivir Transdermal System in Healthy Subjects

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 AWA-M (M1)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Lupus

ORG_CITY: CHARLESTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative Fifty percent of patients with lupus fail to respond to current treatment options, while Mesenchymal Stromal Cells (MSCs) are a safe novel approach to treating lupus refractory to standard of care. We are 75% enrolled in the first randomized multicenter trial of MSCs for patients with active lupus. The ongoing and newly proposed mechanistic studies will provide key understanding into immunologic effects of the MSCs.

PI_NAMEs: GILKESON, GARY S (contact);KAMEN, DIANE L

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: adaptive immunity;Address;Aliquot;Allogenic;Area;Autoimmune Diseases;Autologous;Azathioprine;B-Lymphocytes;Back;belimumab;Benchmarking;Biological Assay;Biological Products;Biological Response Modifiers;blind;Blinded;Cell Therapy;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chimeric antigen receptor T cells;China;Clinical;Clinical Trials;cohort;cost;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;Detection;Development;Disease;Dose;Double-Blind Method;efficacy evaluation;Enrollment;Epigenetic Process;FDA approved;follow-up;Funding;Goals;Grant;Hand;Heterogeneity;Immune;immune function;Immunologics;Immunosuppressive Agents;Immunotherapy;Infrastructure;insight;Laboratories;Lupus;Mediating;meetings;mesenchymal stromal cell;Methodology;Methods;Methotrexate;microbiome;Mononuclear;Multicenter Trials;National Institute of Allergy and Infectious Disease;new technology;novel;novel strategies;novel therapeutics;open data;open label;Participant;Pathogenicity;Patient Recruitments;Patients;Pharmaceutical Preparations;Phase;phase I trial;phase II trial;Placebo Control;placebo controlled trial;Placebos;Plasma;Population;predicting response;primary endpoint;Randomized;receptor;recruit;Refractory;Regulatory T-Lymphocyte;Reporting;response;Safety;Sampling;Signal Transduction;single cell analysis;Specimen;standard of care;Statistical Data Interpretation;Systemic Lupus Erythematosus;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic immunosuppression;Therapeutic Intervention;Time;Toxic effect;treatment effect;treatment group;treatment response;trend;Umbilical cord structure;United States National Institutes of Health

PROJECT_TITLE: A Phase II Controlled Trial of Allogeneic Mesenchymal Stromal Cells for the Treatment of Refractory Lupus (MiSLE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JTS-I (M2)]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE American Joint Replacement Research-Collaborative (AJRR-C) provides methodological expertise and access to nationwide data resources to facilitate innovative, methodologically rigorous and interdisciplinary clinical research in total joint arthroplasty (TJA). The clinical research needs of the TJA research community that are addressed by the AJRR-C include training and mentoring of the next generation of TJA researchers, customized consultations, facilitated access to high quality, rich data sources and national registry data, improvement of statistical methodologies for risk adjustment, new informatics tools and infrastructure for prospective studies.

PI_NAMEs: BERRY, DANIEL  (contact)

PROGRAM_OFFICER_NAME: GREEN PARKER, MELISSA C

PROJECT_TERMS: Academy;Acceleration;Address;Adopted;Adoption;Advisory Committees;American;analytical method;Area;Berry;Big Data;Biometry;Caring;Characteristics;Clinic;Clinical;clinical center;Clinical Data;Clinical Research;Clinical Sciences;Collaborations;Communication;Communities;Computers;Consultations;cost;Data;Data Analyses;Data Collection;Data Element;data registry;data resource;Data Sources;Databases;Development;Disease;Documentation;Education;Effectiveness;Electronic Health Record;Ensure;Environment;Epidemiology;Evaluation;evidence base;experience;flexibility;Future;Goals;Health Services Research;Hip Prosthesis;Implant;improved;improved outcome;informatics infrastructure;informatics tool;Information Technology;Infrastructure;innovation;Institution;Intervention;Intervention Studies;Joint Prosthesis;Knee Prosthesis;Leadership;Link;Medical Informatics;Mentors;Methodology;Modeling;Natural Language Processing;next generation;novel;Observational Study;Operative Surgical Procedures;Orthopedic Surgery;Orthopedics;Outcome;outreach;Patient Care;Patients;Policies;Positioning Attribute;Procedures;Productivity;programs;Prospective Studies;Registries;Replacement Arthroplasty;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;response;Risk Adjustment;Robotics;Safety;Secure;Services;skills;Surgeon;Technology;Time;tool;Training;Translating;Translational Research;Translations;United States;Vision;willingness

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 KM (M1)]


PHR: NARRATIVE The Mayo Clinic American Joint Replacement Research Collaborative (AJRR-C) provides methodological expertise and access to nationwide data resources to facilitate innovative, methodologically rigorous, and interdisciplinary clinical research in TJA. The clinical research needs of the TJA research community that are addressed by the AJRR-C include training of the next generation of TJA researchers, customized consultations, facilitated access to high quality, rich data sources and national TJA registry data as well as informatics and methodology support.

PROJECT_TERMS: Academic Medical Centers;Acceleration;Accounting;Address;Advisory Committees;American;Area;authority;Berry;Clinic;Clinical;clinical center;Clinical Research;Clinical Sciences;Collaborations;Committee Members;Communication;Communities;Consultations;Data;data registry;data resource;Data Sources;Databases;Ensure;Environment;Evaluation;Feasibility Studies;Fellowship Program;flexibility;Funding Agency;Goals;Grant;improved;improved outcome;Individual;Informatics;Information Technology;Infrastructure;innovation;Institution;Leadership;Letters;meetings;member;Methodology;next generation;Orthopedics;Outcome;outreach;Pilot Projects;Positioning Attribute;Process;Professional Organizations;Registries;Regulatory Affairs;Replacement Arthroplasty;Research;Research Personnel;Research Project Grants;Resources;Role;Secure;skills;Societies;Structure;success;Surgeon;tool;Training;Translational Research;Trustees;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Clinical Research

PHR: NARRATIVE The American Joint Replacement Research Collaborative (AJRR-C) provides methodological expertise and access to nationwide data resources to facilitate innovative, methodologically rigorous and interdisciplinary clinical research in TJA. The clinical research needs of the TJA research community that are addressed by the AJRR-C include training of the next generation of TJA researchers, customized consultations, facilitated access to high quality, rich data sources and national TJA registry data as well as informatics and methodology support.

PI_NAMEs: MARADIT KREMERS, HILAL  (contact)

PROJECT_TERMS: access disparities;Address;Adopted;American;Area;Clinic;clinical center;clinical infrastructure;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;Consultations;Data;data management;data registry;data resource;Data Sources;Databases;disease registry;Disparity;Dissemination and Implementation;Education;Educational Materials;Effectiveness;Electronic Health Record;Ensure;Epidemiology;Evaluation;Evidence based practice;Fellowship Program;flexibility;Funding;Future;Goals;Health Services Research;Healthcare Systems;high standard;Hospitals;Human Resources;implementation research;Improve Access;Informatics;informatics tool;Infrastructure;innovation;Institution;Intervention Studies;Link;Mentors;Methodology;Methods;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural Language Processing;next generation;novel;Observational Study;Online Systems;Operative Surgical Procedures;Orthopedics;Outcome;Outcomes Research;Patient Outcomes Assessments;Productivity;programs;Prospective Studies;protocol development;Recording of previous events;Registries;Replacement Arthroplasty;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Resources;Retrospective Studies;Risk Adjustment;Risk Factors;Science;Services;Severity of illness;Standardization;Statistical Data Interpretation;statistics;study population;success;surgical risk;systems research;Technology;Training;Translational Research

PROJECT_TITLE: Methodology Core


PHR: NARRATIVE The Mayo Clinic American Joint Replacement Research-Collaborative (AJRR-C) provides access to nationwide data resources and a network of institutions to facilitate innovative, methodologically rigorous and interdisciplinary clinical research in TJA. AJRR-C addresses the clinical research needs of the TJA research community through training of the next generation of TJA researchers, providing customized consultations, facilitated access to high quality, rich data sources and national TJA registry data as well as infrastructure and methodology support.

PROJECT_TERMS: Academy;Acceleration;Address;administrative database;American;Area;artificial intelligence algorithm;Benchmarking;benefit sharing;Berry;care outcomes;Caring;Characteristics;Clinic;Clinical Research;Clinical Trials;Collaborations;Communities;Consultations;cost;Coupled;Data;Data Analyses;Data Collection;data hub;Data Linkages;data registry;data resource;data sharing networks;Data Sources;Databases;design;Devices;Dissemination and Implementation;District of Columbia;Effectiveness;Electronic Health Record;Evidence based practice;experience;Feasibility Studies;Funding;Future;Goals;health care service organization;health plan;Hip region structure;Hospitals;Implant;improved;Infrastructure;innovation;Institution;Knee;Knowledge;Leadership;Link;Manuals;Manufacturer;Methodology;Methods;Monitor;next generation;novel;Observational Study;Operative Surgical Procedures;Orthopedics;Outcome;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Performance;Pilot Projects;post-market;Procedures;programs;prospective;protocol development;Registries;Replacement Arthroplasty;Research;Research Design;Research Personnel;Residual state;Resources;Risk Adjustment;Risk Factors;Safety;Science;Site;Statistical Data Interpretation;Statistical Methods;Surgeon;surgical risk;Technology;Testing;Text;tool development;Training;United States;Validation;Work

PROJECT_TITLE: Resource Core


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: In the last few years, “missed” diagnostic test results, i.e., those with absent or delayed follow-up, have been determined to be a significant patient safety problem in the VA. While thousands of veterans have abnormal test results every day, there are currently no methods to identify opportunities to reduce care delays. Rigorous measurement and improvement of diagnostic safety can thus benefit veterans and should be prioritized given the increasing amount of electronically available data. We will develop a multi-faceted measurement and improvement approach and build on recommendations from the recent IOM report “Improving Diagnosis in Health Care” to improve veterans' outcomes related to follow-up of abnormal test results. We will develop and evaluate a new VA facility-based systems approach for surveillance and improvement of test results follow-up. Our project is relevant to several VA national policy initiatives related to measurement and safety improvement and builds on our extensive work in improving patient safety related to the diagnostic process.

PI_NAMEs: SINGH, HARDEEP  (contact)

PROJECT_TERMS: Address;Affect;Area;Assessment tool;Caring;Catalogs;Clinical;Communication;Data;data warehouse;Development;Diagnosis;Diagnostic;Diagnostic tests;Electronic Health Record;Electronics;empowerment;Ensure;Evaluation;Event;experience;Failure;Feedback;follow-up;Goals;health care service organization;health information technology;Health Services Research;Health system;Healthcare;Healthcare Systems;high risk;Human Resources;Image;implementation evaluation;improved;Informatics;Information Technology;innovation;Intervention;Leadership;Learning;Malpractice;Manuals;Measurement;Measures;Medical Records;meetings;Methods;Monitor;Notification;novel;operation;Outcome;Outcome Measure;Output;Participant;patient safety;Patients;Pattern;Performance;Persons;pilot test;Policies;Predictive Value;prevent;Primary Care;Process;programs;Provider;Randomized, Controlled Trials;Recommendation;Records;Reporting;resilience;Risk;Risk Assessment;Safety;safety testing;Science;Secure;Self Assessment;Series;Signal Transduction;Site;social;surveillance data;Surveillance Program;System;Test Result;Testing;Time;tool;Translating;Veterans;virtual;Work

PROJECT_TITLE: Measuring and Improving the Safety of Test Result Follow-Up

STUDY_SECTION_NAME: Special Emphasis Panel[HSR9]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);Pediatric;Prescription Drug Misuse;Substance Misuse

ORG_CITY: SAN MARCOS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEXAS STATE UNIVERSITY

PHR: PROJECT NARRATIVE Adolescents and young adults (AYAs) have the highest prevalence rates of prescription drug misuse (PDM) and increasing rates of overdose from PDM, but little research has examined longitudinal changes or age, time period, and cohort differences in PDM, PDM from multiple medication classes, and polysubstance use that involves PDM in AYAs. This research program will examine longitudinal change and age-period-cohort differences in PDM in AYAs, aged 12 to 30 years, to identify at-risk AYAs in need of targeted screening, prevention and treatment. As such, this research is relevant to the mission of the National Institute on Drug Abuse (NIDA) because it will allow researchers and clinicians to prevent PDM at the most vulnerable periods and intervene in those AYAs most in need of treatment for PDM.

PI_NAMEs: SCHEPIS, TY STEPHEN (contact)

PROGRAM_OFFICER_NAME: PARKER, ERIN MARGARET

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;Adoption;Age;age difference;age effect;age group;Age Years;aged;Alcohols;Behavior;Characteristics;cohort;Data;Data Set;Development;deviant;Disparate;Drug Prescriptions;Drug usage;Education;Educational Status;Employment;experience;Future;Goals;Health;Health Benefit;health data;Heroin;High Prevalence;high-risk adolescents;Household;Incidence;Ingestion;innovation;Intervention;Investigation;Knowledge;Life Cycle Stages;Link;Longitudinal trends;Marijuana;Marital Status;Marriage;Measures;Mission;misuse of prescription only drugs;Modeling;Monitor;National Institute of Drug Abuse;Opioid;Outcome;Overdose;parent project;Pattern;Pharmaceutical Preparations;Policies;polysubstance use;power analysis;Prescription drug overdose;Prevalence;prevent;Prevention;Process;programs;Progress Reports;Psychopathology;psychostimulant;Public Health;Publications;Recording of previous events;Research;Research Personnel;Risk;screening;sedative;social attachment;Source;Stimulant;substance use;Substance Use Disorder;Surveys;Symptoms;Techniques;theories;Time;Tobacco;Tranquilizing Agents;trend;vulnerable adolescent;young adult

PROJECT_TITLE: Longitudinal Changes in Prescription Drug Misuse and Polysubstance Use in Adolescents and Young Adults

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Conditions Affecting the Embryonic and Fetal Periods;Dietary Supplements;Fetal Alcohol Spectrum Disorders (FASD);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Fetal alcohol spectrum disorders (FASD) represent the most widespread manifestation of preventable intellectual disability. Our preliminary data suggest that choline supplementation initiated early in pregnancy can ameliorate adverse growth retardation and some of the debilitating neurocognitive effects seen in FASD. In the current study, we will add neonatal brain anatomical, diffusion and metabolic imaging to our recently- funded, fully-powered clinical trial of choline supplementation in heavy drinking pregnant women in the Western Cape province of South Africa. This study will contribute to our understanding of the mechanistic underpinnings of the neuroprotective benefits of prenatal maternal choline supplementation to the developing fetus exposed prenatally to alcohol and has the potential to inform prenatal interventions and postnatal FASD remediation.

PI_NAMEs: CARTER, ROBERT COLIN;JACOBSON, SANDRA W.;MEINTJES, ERNESTA MARIA;VAN DER KOUWE, ANDRE JAN WILLEM (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Acetylcholine;Adverse effects;Affect;Age Months;Alcohols;Anatomy;Animals;Anisotropy;Area;arm;autism spectrum disorder;Award;Birth;Brain;Brain region;brain volume;Cell membrane;Cells;Cellular Structures;Choline;choline supplementation;Clinical;Clinical Trials;Cognitive;Cognitive deficits;cognitive development;cognitive testing;Collaborations;Communities;Community Practice;conditioned fear;Counseling;Coupled;Data;deep learning;Development;dietary;Dietary Supplementation;Diffusion;Diffusion Magnetic Resonance Imaging;Disadvantaged;DNA Methylation;Dose;Double-Blind Method;Down's Syndrome;drinking;Energy Metabolism;Enrollment;eyeblink conditioning;fetal;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Development;Fetus;Funding;General Hospitals;Gestational Age;Grant;Growth;Growth and Development function;Head circumference;Heavy Drinking;high risk;Hippocampus;HIV;human study;improved;Infant;infant outcome;information processing;Intake;Intellectual functioning disability;Intervention;Investments;Knowledge;Learning;Length;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Massachusetts;Measurable;Measurement;Measures;Mediating;medical schools;memory recognition;Metabolic;metabolic imaging;Metabolism;methyl group;Modeling;multimodality;N-acetylaspartate;National Institute on Alcohol Abuse and Alcoholism;Neonatal;neonatal brain;neonatal magnetic resonance imaging;neonate;Nervous System Trauma;Neural Tube Closure;Neurocognitive;neurodevelopment;neuroimaging;neuromechanism;neuroprotection;Neurotransmitters;Newborn Infant;Nutrient;Nutritional;Nutritional status;Outcome;Perinatal;Placebo Control;Placebos;postnatal;Pregnancy;Pregnant Women;prenatal;prenatal intervention;Prevalence;primary outcome;processing speed;Province;psychosocial;Public Health;Randomized;randomized placebo controlled trial;randomized placebo-controlled clinical trial;randomized, clinical trials;recruit;remediation;Research Personnel;Research Priority;Rett Syndrome;Role;rural area;secondary outcome;Short-Term Memory;South Africa;spectrograph;standard of care;Structure;Supplementation;Test Result;Treatment Efficacy;United States National Institutes of Health;Universities;Weight;white matter;Woman

PROJECT_TITLE: Fetal Neuroprotection by choline supplementation in heavy drinking pregnant women

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetic Testing;Genetics;Human Genome;Infant Mortality;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: CAMBRIDGE

ORG_NAME: FRAMESHIFT LABS, INC.

PHR: Narrative We are building a complete, commercial software solution to enable team-based genomic analysis in all settings, including, but not limited to, challenging diagnostic cases in undiagnosed diseases clinics and rapid sequencing programs in newborn intensive care units. Our software will include secure computational pipelines to process genomic data that can be deployed on the cloud, or on institutional hardware, and visual data portals that make access to, and analysis of, this data available to all. We will evaluate and refine these tools in team-based settings in the NHGRI funded Undiagnosed Diseases Network clinical site, and newborn intensive care unit at the University of Utah.

PI_NAMEs: WARD, ALISTAIR  (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Address;Adopted;Algorithms;analysis pipeline;Bioinformatics;bioinformatics pipeline;Caring;citizen science;Clinic;clinical research site;cloud based;cohort;Collaborations;Communication Tools;Communities;Community Hospitals;Complex;computational pipelines;computer infrastructure;Computer software;critically ill newborn;Custom;Data;data management;data portal;data sharing;design;Diagnosis;Diagnostic;Disease;drug development;effectiveness evaluation;Ensure;Environment;Evaluation;experience;Family;Feedback;Foundations;Funding;Genes;genetic counselor;Genetic Diseases;Genetic Services;genetic testing;genetic variant;Genome;genome sequencing;genomic data;Genomics;Goals;Individual;Institution;interest;Intuition;Investigation;Knowledge;Manuals;Marketing;Medical;member;Metadata;Modeling;mosaic;National Human Genome Research Institute;Neonatal Intensive Care Units;Notification;Online Systems;Pain;Patients;Pharmacologic Substance;Phenotype;Physicians;portability;Privacy;Process;programs;Quality Control;Rare Diseases;Recording of previous events;Research;restraint;Role;scale up;Scientist;Secure;Security;Services;software systems;Source;Specialist;Standardization;Suggestion;support tools;Technology;Time;tool;Universities;Update;user-friendly;Utah;Variant;Visual;Visualization;web app;web platform;whole genome

PROJECT_TITLE: A state-of-the-art web platform for collaborative, longitudinal genome diagnostics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-J(11)B]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: HERSHEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Damage to the cerebellum often leads to nonmotor deficits. Trauma to the cerebellum is a strong predictor of post-traumatic stress disorder. Understanding the substrates for cerebellar roles in nonmotor behaviors may lead to targeted interventional approaches to ameliorate the symptoms of any disorders that arise from cerebellar dysfunction.

PI_NAMEs: CHEN, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Affect;Aggressive behavior;Amygdaloid structure;Anatomy;Animals;Area;autism spectrum disorder;awake;Axon;basal forebrain;Behavior;Behavioral;Brain;Brain region;Cell Nucleus;Cells;Cerebellar Cortex;Cerebellar Diseases;Cerebellar Nuclei;Cerebellum;Code;Cognition;conditioned fear;Data;Development;Disease;executive function;Extinction;Fright;Halorhodopsins;Head;Heart Rate;Human;human imaging;imaging study;In Vitro;in vivo;Intervention;Label;Language;Learning;Link;Literature;Lobule;Location;LoxP-flanked allele;Mediating;Molecular Profiling;Motor;Movement;Mus;Mydriasis;Negative Valence;neural;Neurons;novel;Optics;Output;parabrachial nucleus;Pathway interactions;Phase;Post-Traumatic Stress Disorders;pre-clinical;Prefrontal Cortex;prevent;Property;Prosencephalon;Proteins;Purkinje Cells;Reaction;reduce symptoms;response;Rest;restraint;Role;selective expression;sensory stimulus;Sleep;Socialization;Stimulus;Structure;Synapses;Synaptophysin;Testing;theories;Transgenic Animals;Trauma;Vestibular nucleus structure;Virus;Visceral;Work

PROJECT_TITLE: Cerebellar Outputs Through an Unconventional Nucleus

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Prostate cancer is the second-most common malignancy in men and other people with prostates worldwide, yet we do not fully understand the genetic events that drive tumor initiation or drug resistance. While the hallmark alterations of prostate cancer have been reported, the functional consequences of most mutations remain unknown. We aim to identify the mechanisms by which IRS4 gain of function drives tumor initiation and CDK4 gain of function drives drug resistance in prostate cancers with PTEN loss, which will contribute fundamental insight into the altered cell circuitry in prostate cancer and identify potential therapeutic targets.

PI_NAMEs: RYAN, MATTHEW JAMES (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Acceleration;advanced prostate cancer;Alanine;Androgen Receptor;Automobile Driving;Binding;Binding Sites;burden of illness;Bypass;Cancer Biology;Cancer cell line;cancer drug resistance;cancer genetics;cancer genomics;cancer initiation;career;CDK4 gene;CDKN2A gene;Cell Cycle;Cell Cycle Progression;Cells;Clinical;Complement;Comprehensive Cancer Center;Cyclin-Dependent Kinase Inhibitor 2A;Data;Detection;Disease;Disease Progression;DNA Binding;DNA Mismatch Repair Protein MSH2;Doctor of Philosophy;Drug resistance;EDN2 gene;Engineering;Event;Evolution;exome sequencing;experience;Family;Fellowship;Fostering;Foundations;functional genomics;G1/S Checkpoint Pathway;gain of function;gain of function mutation;Gene Expression;gene function;gene repair;Genes;Genetic;genetic corepressor;Genetic Drift;Genetic Models;Genetic Transcription;genetic variant;Genetically Engineered Mouse;Genomic approach;Genomics;Growth;health disparity;Human;improved;In Vitro;in vivo;inhibitor;insertion/deletion mutation;insight;IRS4 gene;Knock-out;Knockout Mice;Lesion;Malignant neoplasm of prostate;Malignant Neoplasms;MAP Kinase Gene;Measures;Mediating;Medical Oncologist;men;Mentorship;Mismatch Repair;Missense Mutation;multiple omics;Mus;Mutagenesis;Mutation;Oncogenes;Organoids;overexpression;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase I Clinical Trials;Phenotype;Phosphorylation;Phosphotyrosine;PIK3CG gene;Point Mutation;pre-clinical;Preceptorship;preclinical study;premalignant;Prevalence;prevent;programs;Proliferating;Prostate;Prostatic Neoplasms;PTEN gene;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Recurrence;Reporting;Research Personnel;Resistance;response;Role;Sampling;Secure;Signal Transduction;standard of care;System;Testing;therapeutic target;Training;Transcription Alteration;transcription factor;tumor;tumor growth;tumor initiation;Tumor Suppressor Proteins;tumorigenesis;Variant;Work

PROJECT_TITLE: Dissecting Early Tumor Evolution to Uncover Mechanisms of Tumor Initiation and Drug Resistance


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Chronic Pain;Clinical Research;Congenital Structural Anomalies;Digestive Diseases;Drug Abuse (NIDA only);Neurosciences;Pain Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Substance Misuse

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE The neurodevelopmental impact of prolonged sedation (in weeks) as part of the complex perioperative care is infancy is unknown. This proposal is relevant to the part of the NICHD and NIDA’s mission as it will investigate structural and clinical care aspects of early brain development in esophageal atresia - the most common gastro- intestinal birth defect, using structural MRI and neurobehavioral evaluations. The findings will inform the development of rational infant neuroprotective therapies to prevent and minimize neurodevelopmental sequalae in critically ill infants and help reduce the burden to human disability.

PI_NAMEs: BAJIC, DUSICA  (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: 1 year old;Address;Age Months;age related;Amygdaloid structure;Anesthesia procedures;Anisotropy;Award;Basal Ganglia;Brain;brain abnormalities;brain magnetic resonance imaging;Brain region;brain size;brain volume;Characteristics;Chest;Child;Childhood;Clinical;clinical care;Clinical Data;cohort;Collaborations;Complex;Congenital Abnormality;Corpus Callosum;Critical Care;Critical Illness;Data;Data Collection;Dependence;Development;Diagnostic;Diffusion Magnetic Resonance Imaging;disability;Drug Modulation;Early identification;Esophageal Atresia;Evaluation;Exhibits;experience;Exposure to;Extracorporeal Circulation;Foundations;Future;gastrointestinal;Gestational Age;Goals;gray matter;Growth;high risk infant;Human;human old age (65+);improved;Incidence;infancy;Infant;Infant Care;innovation;international center;Knowledge;Lead;Life;Liquid substance;Longitudinal cohort study;Magnetic Resonance Imaging;Manuscripts;Maps;Measures;medical complication;Mission;National Institute of Child Health and Human Development;National Institute of Drug Abuse;Neonatal;neonate;neurobehavioral;Neurocognitive;neurodevelopment;neuroimaging;Neurologic Effect;neuroprotection;Neurotransmitters;Nociception;novel;Operative Surgical Procedures;opiate tolerance;Opioid;opioid exposure;Outcome;Outcome Study;Pain;pain processing;Pathway interactions;Pediatric Radiologist;Perioperative;Perioperative Care;Pharmaceutical Preparations;Physical Dependence;Play;postnatal;Postoperative Period;premature;Premature Infant;prevent;prognostic indicator;prospective;Publications;recruit;repaired;Reporting;Research;Risk;Role;Scanning;Sedation procedure;Sensory;sex;Shapes;Site;Socioeconomic Status;Specificity;Structure;Techniques;Thalamic structure;Time;Toddler;tool;tractography;United States;white matter

PROJECT_TITLE: Impact of Prolonged Perioperative Sedation on Infant Brain

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: The proposed project seeks to identify molecular changes in chronic inflammatory skin diseases of the elderly and utilize these patterns to develop a precision medicine approach to optimize choice of targeted therapy blocking specific inflammatory pathways.This is highly relevant to veteran’s health given the older average age.of veterans and the often difficult to treat and highly symptomatic nature of these diseases.

PI_NAMEs: CHENG, JEFFREY B (contact)

PROJECT_TERMS: Adhesions;Adult;Age;Age Years;aging population;aging related;algorithm training;Atopic Dermatitis;Biological Assay;Biological Markers;biomarker discovery;burden of illness;Candidate Disease Gene;cell motility;Cells;Childhood;chronic inflammatory disease;chronic inflammatory skin;Chronic small plaque psoriasis;classification algorithm;Clinical Trials;Complex;CRISPR/Cas technology;Cutaneous;Dermatologic;Disease;disorder subtype;Dissection;DNA;Elderly;Epigenetic Process;experience;Functional disorder;Gene Expression Profile;Genes;Genetic;Genetic Heterogeneity;genetic signature;Genetic Transcription;Genomics;Goals;Health;Heterogeneity;Human;human old age (65+);Immune;immune modulating agents;Immune System Diseases;improved;Individual;individual patient;Inflammation;Inflammatory;interleukin-23;Investigation;Legal patent;Methods;military veteran;Molecular;Molecular Abnormality;molecular pathology;multiple omics;Mus;Nature;novel;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Phenotype;precision medicine;Prevalence;Qualifying;Resolution;response;response biomarker;RNA;Role;Sampling;single-cell RNA sequencing;Skin;skin disorder;Stromal Cells;Subgroup;T-Lymphocyte;targeted treatment;Testing;Therapeutic;tissue resident memory T cell;tool;transcriptomics;treatment choice;Treatment Failure;treatment optimization;treatment response;Validation;Variant;Veterans

PROJECT_TITLE: Precision medicine approaches to chronic inflammatory skin disease of older veterans


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE People with substance use disorders (SUD) in the criminal legal system often cannot access SUD treatment– and those who do are less likely to receive evidence-based services–which can reinforce pathways that worsen community health. We will study the dynamics between the criminal legal system and community SUD treatment system to generate unprecedented cross-sector evidence of the spillover effects of county incarceration on community SUD treatment need, availability, use, and outcomes, and racial/ethnic and gender disparities therein. With input from experts and people with lived experience, we will disseminate findings to inform antiracist health policies that can transform the criminal legal and SUD treatment systems to reduce SUD-related morbidity and mortality.

PI_NAMEs: MAURO, PIA M. (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Accident and Emergency department;Accounting;Address;Admission activity;Adult;Affect;Alcohol consumption;anti-racism;Biometry;Black race;Cessation of life;Communities;community engagement;Community Health;community reentry;County;Criminology;Data;Data Set;Data Sources;Death Rate;Dependence;Discrimination;Disparity;dissemination strategy;Drug usage;Emergency department visit;Emergency Situation;Ensure;Epidemic;Epidemiology;Equation;ethnic disparity;ethnic minority population;Ethnic Origin;evidence base;Exposure to;Face;Funding;Gender;gender disparity;Health;health care delivery;Health Policy;Health Services;Health Services Research;Health system;Imprisonment;improved;Individual;Inequity;innovation;interest;Investments;Jail;Justice;Knowledge;Latinx;Legal;Legal system;Link;Lived experience;medical specialties;medication for opioid use disorder;men;Methodology;Methods;Minority Groups;Modeling;Morbidity - disease rate;mortality;multilevel analysis;National Institute of Drug Abuse;Outcome;outcome disparities;Overdose;overdose death;overdose risk;parole;Pathway interactions;Patient Self-Report;Persons;Pharmaceutical Preparations;Policies;Policy Maker;population health;Prevalence;Prisons;probation;Process;programs;Public Health;Race;racial disparity;racial minority population;recidivism;reduced substance use;reincarceration;Research;Research Personnel;service delivery;Services;social culture;substance abuse treatment;substance use;Substance Use Disorder;substance use treatment;Suicide;Supervision;Surveys;System;Testing;Thinking;Time;Trauma;treatment disparity;Treatment outcome;treatment services;trend;United States;Visit;Vital Statistics;Vulnerable Populations;Woman;women versus men

PROJECT_TITLE: Substance use treatment and county incarceration: Reducing inequities in substance use treatment need, availability, use, and outcomes

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Rural Health;Social Determinants of Health;Substance Misuse;Violence Research

ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE The proposed research is focused on understanding the public health impact of daily experiences with discrimination, harassment, and stigmatization experienced by sexual and gender minority couples living in rural communities in the Midwest. We aim to isolate key factors that increase the likelihood of alcohol use and destructive conflict in response to distress experienced from daily minority stress (i.e., drinking to cope motives and internalized forms of minority stress). We will also identify sources of resiliency arising from interpersonal relationships and community-based resources that interrupt this maladaptive cascade and mitigate risk for the dual public health threats of alcohol use and intimate partner violence in this underrepresented population.

PI_NAMEs: BROCK, REBECCA L (contact);DILILLO, DAVID

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Alcohol abuse;Alcohol consumption;alcohol misuse;alcohol myopia;Alcoholic Intoxication;Alcohols;cisgender;Communities;Conflict (Psychology);Consumption;coping;Couples;Data;diaries;Discrimination;Distal;Distress;drinking;experience;Exposure to;Feeling;Frequencies;Fright;gender minority group;harassment;health disparity;Heavy Drinking;Heterosexuals;High Prevalence;Homophobia;Individual;Interpersonal Relations;Interruption;Intervention;intimate partner violence;Lesbian Gay Bisexual Transgender;Lesbian Gay Bisexual Transgender Queer;Link;Literature;Methods;Midwestern United States;minority stress;Modeling;Neighborhoods;novel;Outcome;Participant;Pathway interactions;Pattern;peer;perceived discrimination;Population;Process;protective factors;psychologic;psychological distress;Public Health;queer;recruit;Reduce health disparities;Registries;Research;Residencies;resilience;resilience factor;Resources;response;Risk;risk mitigation;Rural;rural area;Rural Community;rural residence;Sampling;Severities;Sexual and Gender Minorities;sexual encounter;sexual minority group;social;social stigma;Social support;Source;Stigmatization;Stress;stressor;Testing;theories;transphobia;Underrepresented Populations;urban area;Violence;Work

PROJECT_TITLE: Experiences of Rural Sexual and Gender Minority Couples: Does Alcohol Use Explain the Link Between Minority Stress and Intimate Partner Discord and Violence

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: PORTLAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative This research program is creating new genetic tags and workflows for studying receptor organization by fluorescence and electron microscopy (“multiscale microscopy”). This research is relevant to the mission of NIGMS to support the development of technologies designed to advance our understanding of how living systems function. Our innovative technologies are compatible with the microscopes found at most institutes or NIH-funded imaging centers.

PI_NAMEs: BEATTY, KIMBERLY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Affinity;Antibody Specificity;Binding;Biology;biomaterial compatibility;catalyst;Chemicals;Color;Computer Analysis;design;Dimensions;Dimerization;Disease;Electron Microscopy;Electrons;Fluorescence Microscopy;fluorophore;Funding;Genetic;high resolution imaging;Image;imaging facilities;imaging study;innovation;innovative technologies;instrumentation;Iron;Label;light microscopy;Methods;Microscope;Microscopy;Mission;Molecular;Mutation;Names;nanoparticle;National Institute of General Medical Sciences;new technology;novel;Organism;Peptides;Pharmaceutical Preparations;programs;protein function;protein structure;Proteins;receptor;Reporter;Research;Research Personnel;sensor;single molecule;small molecule;Technology;technology development;TFRC gene;Time;trafficking;transferrin receptor 2;United States National Institutes of Health;uptake;user-friendly;Whole Organism;Work

PROJECT_TITLE: Labeling cellular proteins for multi-scale microscopy and other applications

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative The most accurate current methods for understanding text with computers have severe restrictions on the lengths of the text that they can process, which is a severe limitation for current systems’ understanding of electronic health records. In this project, we first propose new algorithms that can handle longer text sequences, along with innovative ways to learn the models. Our second major goal is to incorporate multiple data types in the same architecture, combining structured data from traditional databases, unstructured text, and images. We evaluate our proposed methods on several important clinical tasks, including predicting injury severity in patients in the emergency department, diagnoses in intensive care unit patients, and several prognostic variables in intensive care unit patients.

PI_NAMEs: MILLER, TIMOTHY A (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Accident and Emergency department;Address;Algorithms;Architecture;Area;Chest;Classification;Clinical;Clinical Research;Code;Competence;Complex;Computers;Data;Data Aggregation;data fusion;data modalities;Data Set;Databases;Decision Making;Development;Diagnosis;E-learning;Electronic Health Record;Experimental Designs;experimental study;frontier;Funding;Goals;health data;Health Status;Image;improved;Individual;Injury;innovation;Intensive Care Units;Knowledge;language training;Learning;Length;light weight;Link;Machine Learning;machine learning algorithm;Maps;Medical;Methods;Modality;Modeling;multimodality;multiple data types;neural;neural model;novel;Output;Patient Care;Patient Education;patient prognosis;Patients;Performance;Phenotype;point of care;pre-trained model;pre-trained transformer;prevent;Privatization;Process;Productivity;prognostic;Research;Severities;Source;Structure;structured data;Supervision;System;Techniques;Terminology;Text;Time;Training;Unified Medical Language System;usability;Work

PROJECT_TITLE: Learning Universal Patient Representations with Hierarchical Transformers

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Primary Immunodeficiencies;Rare Diseases;Sickle Cell Disease

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: In this study we test a novel hypothesis that inherited variability in genes of red blood cell proteins significantly modulate RBC function and recovery after transfusion. We will explore how donor genotype determines the time limits of blood storage and recovery of cells after storage, to identify super donors versus fragile donors.

PI_NAMEs: GLADWIN, MARK T (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Address;African American;ANK1 gene;antioxidant enzyme;Autologous;Biophysics;Biotin;Blood;Blood donor;Candidate Disease Gene;Carrier Proteins;CD34 gene;Cell membrane;Cell Physiology;Cells;Cellular Metabolic Process;Cellular Structures;Collaborations;Coupled;CRISPR/Cas technology;Crossbreeding;Cryopreservation;density;Development;Equilibrium;Erythrocyte Transfusion;Erythrocytes;Erythropoiesis;Erythropoietin;Exhibits;FDA approved;G6PD gene;Genes;Genetic;Genetic Engineering;genetic pedigree;Genetic Polymorphism;genome wide association study;genome-wide;Genotype;Glucosephosphate Dehydrogenase Deficiency;Golgi Apparatus;Grant;Hemolysis;high risk;Human;human female;humanized mouse;Image;Impairment;In Vitro;in vivo;Inherited;insight;Ion Channel;Knock-out;Label;Lesion;life span;Lipids;Malaria;male;Membrane Lipids;Membrane Proteins;men;Metabolism;metabolomics;Modeling;mouse model;Mus;Mutation;novel;Osmosis;Outcome;patch clamp;Pathologic;Pathway interactions;patient population;Patients;Physiological;Piezo 1 ion channel;Population;pressure;programs;Proteins;Protocols documentation;Pyruvate Kinase;Recovery;Research;response;Role;Sickle Cell Anemia;Sickle Cell Trait;Signal Pathway;Single Nucleotide Polymorphism;Sorting;Stress;Structure;Testing;Time;trafficking;Transfusion;transfusion medicine;Transgenic Organisms;Variant

PROJECT_TITLE: Omics, mice and men: Development of precision transfusion medicine

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Genetics

ORG_CITY: NOTRE DAME

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE Synonymous codon substitutions are typically regarded as “silent” and “neutral.” Yet, synonymous mutations can significantly alter the folding mechanism of the encoded protein, leading to adverse effects on cell fitness. With this project, I will develop a novel experimental approach to broadly and deeply define the types of proteins most sensitive to codon usage and the codon usage patterns that best support the folding of proteins to their native, active structures.

PI_NAMEs: CLARK, PATRICIA LOUISE (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Adverse effects;Amino Acid Sequence;Award;Buffers;cell growth;Cells;Codon Nucleotides;Complex;design;Disease;fitness;Genetic;Genetic Diseases;Genome;Genomics;Goals;Human Genetics;in vivo;Lead;Link;Measures;Molecular Chaperones;Mutation;next generation;novel;novel strategies;Pattern;Peptide Hydrolases;Phenotype;Predisposition;preservation;Production;protein folding;protein function;Proteins;Proteome;proteostasis;Regulation;Structure;Time

PROJECT_TITLE: Decoding the regulation of protein folding by synonymous codon usage


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Disability Research;Dissemination and Implementation Research;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Social Determinants of Health;Substance Misuse

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Evidence-based resources and supports are lacking for adolescents and adults with fetal alcohol spectrum disorders (FASD). Yet, the transition to adulthood is a critical developmental period requiring appropriate supports to foster quality of life. The proposed project aims to develop and initiate evaluation of a person-centered planning intervention called Thrive for adolescents and adults with FASD.

PI_NAMEs: PETRENKO, CHRISTIE LYNN MCGEE (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;Adolescent and Young Adult;Adult;Advocate;Age;Attention;Awareness;barrier to care;care systems;Caring;Communities;Community Participation;community setting;comparison group;Competence;Complex;critical developmental period;Data;Decision Making;design;Development;Developmental Disabilities;digital tool;Disabled Persons;Documentation;effectiveness outcome;effectiveness/implementation hybrid;effectiveness/implementation trial;empowerment;Evaluation;evidence base;Evidence based intervention;experience;Family;Fetal Alcohol Spectrum Disorder;follow-up;Fostering;Future;Geography;Goals;Group Interviews;Group Meetings;Health Sciences;implementation framework;implementation outcomes;implementation science;improved;Individual;Intervention;intervention mapping;intervention refinement;Interview;Literature;Logic;Measures;member;Mental Health;Methodology;Methods;Modeling;Monitor;multidisciplinary;Neurobehavioral Manifestations;Outcome;Participant;Pathway Analysis;Patient Self-Report;person centered;Persons;Phase;physical conditioning;pilot trial;Population;Positioning Attribute;Preparation;Procedures;Process;Production;programs;Protocols documentation;Psychology;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Records;recruit;Research;Research Activity;Resources;Sampling;satisfaction;Self Determination;service utilization;Services;Social Environment;Social Network;social network intervention;social stigma;Social support;Specific qualifier value;Structure;support network;System;system-level barriers;Target Populations;Technology;Testing;theories;transition to adulthood;Translations;trial design;usability;Work

PROJECT_TITLE: Developing a Scalable FASD-Informed Person-Centered Planning Intervention

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ORG_NAME: BALTIMORE VA MEDICAL CENTER

PHR: Since current clinical imaging (MRI/PET) can only detect tumors larger than 10 million tumor cells, it is exceedingly difficult to distinguish whether cancer therapies shrink tumor size by killing tumors or causing tumor cell scattering. These two scenarios have vastly different implications for the metastatic spread of cancer that eventually causes patient death. There are now more than 2.2 million women Veterans in the United States, and the health concerns of this growing female Veteran population are a VA priority. The National Cancer Institute estimates that 1 out of 8 women will develop breast cancer in their lifetime, yielding a current population of 275,000 female Veterans who will confront breast cancer and require effective treatment. This project will develop strategies to improve breast cancer treatment for the growing female Veteran population.

PI_NAMEs: MARTIN, STUART S (contact)

PROJECT_TERMS: Acceleration;Actins;Affect;Animals;Antineoplastic Agents;Area;automated image analysis;Behavior;Biomedical Engineering;Blood Circulation;Blood Vessels;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;Cancer Center;cancer imaging;cancer recurrence;cancer risk;cancer therapy;cell growth;Cell membrane;Cells;Cessation of life;Characteristics;chemotherapy;Clinical;clinical imaging;Clinical Treatment;clinically relevant;confocal imaging;Confocal Microscopy;Core Biopsy;Cytoskeleton;Detection;Distant;drug testing;Early Diagnosis;effective therapy;Ensure;epithelial wound;Epothilones;ERBB2 gene;FDA approved;Female;Growth;Health;Hour;Image;improved;in vivo;Incidence;Individual;individual patient;individual response;individualized medicine;Institution;Laboratories;Legal patent;Licensing;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammospheres;Maryland;Measurement;Measures;Metastatic/Recurrent;Methods;Microfluidic Microchips;microfluidic technology;Microfluidics;Microtubules;military veteran;Modeling;Modification;Molecular;molecular marker;molecular phenotype;Molecular Profiling;mouse model;multidisciplinary;Mus;National Cancer Institute;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;new technology;novel;Operative Surgical Procedures;optical imaging;patient derived xenograft model;Patient Noncompliance;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;phenotypic biomarker;Population;Positron-Emission Tomography;pressure;prevent;Publishing;Recurrence;Research Priority;Residual state;response;response biomarker;Risk;risk minimization;Sampling;stem cells;stemness;Surface;System;Tail;taxane;Technology;Testing;Time Study;tissue culture;Tissues;Translating;Translations;Transplantation;treatment strategy;Tubulin;tumor;tumor growth;United States;Universities;Veins;Veterans;Woman;Women's Health;wound healing

PROJECT_TITLE: Rapid analysis of patient tumor cell drug responses to reduce metastatic risk

STUDY_SECTION: CAMM

STUDY_SECTION_NAME: Cellular and Molecular Medicine[CAMM]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rare Diseases;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_NAME: TUFTS MEDICAL CENTER

PHR: Universal Human Papillomavirus (HPV) vaccination would significantly decrease cervical, vaginal, vulvar, anal, and oral cancers, and reduce racial disparities in these cancers. In this project we will further adapt our Embodied Conversational Agent for HPV system to produce an English and Spanish smartphone ECA-HPV system to provide vaccine recommendations and motivational interviewing to parents/guardians and vaccine-eligible adolescents and facilitate communication with clinic staff. If proven effective, this scalable approach can be broadly implemented and adapted to other childhood, adolescent, maternal, and adult immunizations.

PI_NAMEs: BICKMORE, TIMOTHY W.;PAASCHE-ORLOW, MICHAEL  (contact);PERKINS, REBECCA BERNSTEIN

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: Address;Adolescent;Adult;Age;aged;Ambulatory Care Facilities;animation;Behavior;Boston;cancer health disparity;Caregivers;Cellular Phone;Cervical;chatbot;Child;Childhood;Clinic;Clinic Visits;Clinical Trials;Communication;Computer Interface;Computer Literacy;Computers;Counseling;COVID-19 pandemic;design;Development;Education;Eligibility Determination;empowerment;ethnic minority;Ethnic Origin;Evaluation;Exclusion;Family;global health;Health;Health behavior change;Health care facility;health literacy;Health Professional;Health Status;Hospitals;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papillomavirus;Immunization;improved;Income;Information Systems;innovative technologies;Intention;Intervention;intervention participants;Intuition;Knowledge;Language;low health literacy;malignant mouth neoplasm;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant neoplasm of vulva;Malignant Neoplasms;Malignant Vaginal Neoplasm;Medical;Medical center;minority patient;Misinformation;Monitor;motivational enhancement therapy;New England;non-verbal;Notification;Outcome;Parents;Participant;Patients;Population;premalignant;Preventive care;Primary Care;primary outcome;Race;racial disparity;racial minority;Randomized, Controlled Trials;Recommendation;recruit;Research;response;safety net;secondary outcome;Series;Spanish/English;System;Technology;tertiary care;Time;treatment arm;treatment as usual;Vaccinated;Vaccination;vaccine hesitancy;Vaccines;Variant;verbal;Visit;Work

PROJECT_TITLE: Conversational Agents to Improve HPV Vaccine Acceptance in Primary Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-N(90)]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE The proposed study will provide essential information regarding which intervention targets and strategies are most likely to improve receipt of preventive services and ultimately reduce morbidity among children with SCA. We will use quantitative methods to identify critical targets within the healthcare delivery system, as well as key subgroups of the population, that can be intervened upon to improve the receipt of preventive services, and qualitative methods to identify barriers and facilitators to receipt of these services. We will integrate the findings from the quantitative analysis with the results from the qualitative analysis to fill the gap in understanding specific targets within the healthcare system, key population subgroups, and feasible strategies for interventions to maximize the receipt of preventive services among children with sickle cell anemia.

PI_NAMEs: REEVES, SARAH LEASURE (contact)

PROGRAM_OFFICER_NAME: HARDING, BRENDA

PROJECT_TITLE: Opportunities to optimize the receipt of preventive services among children with sickle cell anemia: A Mixed Methods Approach

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The overall goal of “Diagnostic Innovations in Glaucoma Study (DIGS): Glaucoma and High Myopia” is to improve our understanding and detection of progressive glaucoma in patients who are particularly challenging to correctly diagnose with the disease, individuals with high myopia. The prevalence of myopia is increasing rapidly and Individuals with high myopia are at a higher risk of developing glaucoma. With its extensive longitudinal structural, functional and vascular testing and deep learning analysis strategies, this study will enhance our understanding of the complex relationship between structural, functional and vascular changes in glaucoma and improve our ability to manage the disease and prevent glaucoma-related functional impairment and blindness in individuals with high myopia.

PI_NAMEs: ZANGWILL, LINDA M (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: 3-Dimensional;Address;Age;Aging;American Society of Clinical Oncology;Anterior;Atrophic;Biomechanics;Blindness;Blood Vessels;Bruch's basal membrane structure;Clinical;clinical biomarkers;clinical care;cloud based;cohort;Cohort Studies;Communities;Complex;Data;data curation;data pipeline;data sharing;Databases;deep learning;deep learning algorithm;deep learning model;density;design;Detection;Diagnosis;Diagnostic;Disease;Disease Management;Dropout;Eye;follow-up;Functional disorder;Functional impairment;functional loss;ganglion cell;Glaucoma;Goals;High Prevalence;high risk;Image;improved;Individual;Inner Plexiform Layer;innovation;Japan;Korea;Lead;Length;Link;macula;Maps;Measures;model development;Modeling;Morphology;multimodality;Myopia;novel;Open-Angle Glaucoma;Optic Disk;Optic Nerve;Optical Coherence Tomography;Papillary;patient oriented;Patients;Pattern;Persons;Phenotype;Population;predictive modeling;Predisposition;Prevalence;prevent;Research;Retina;retinal nerve fiber layer;Risk;Scanning;Science;Scotoma;Secure;Statistical Methods;Testing;Texture;Thick;Thinness;vascular factor;Vision research;Visual Fields


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Childhood Injury;Gene Therapy;Genetics;Infant Mortality;Lung;Nanotechnology;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Pulmonary Hypertension;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE. We will use mouse and rat models of Bronchopulmonary dysplasia (BPD) to determine whether neonatal lung angiogenesis, pulmonary hypertension (PH), pathologic lung remodeling and lung regeneration in hyperoxia-injured animals can be improved via nanoparticle-based gene delivery of FOXF1 transcription factor into the pulmonary circulation, or via cell therapy with FOXF1+ general capillary cells (FOXF1+ gCAPs) which serve as progenitors of pulmonary microvascular endothelial cells.

PI_NAMEs: KALINICHENKO, VLADIMIR  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acceleration;Affect;Agreement;Airway Disease;Alveolar;Alveolar capillary dysplasia with misalignment of pulmonary veins;angiogenesis;Animals;Blood capillaries;Blood Vessels;Bronchopulmonary Dysplasia;Cell Therapy;Cell Transplantation;Cells;Childhood;Chimera organism;Chromatin;Chronic;Circulation;Complication;Congenital diaphragmatic hernia;Critical Care;density;directed differentiation;Disease Progression;Donor person;embryonic stem cell;Endothelial Cells;endothelial regeneration;endothelial repair;endothelial stem cell;Endothelium;Engraftment;Enhancers;Environment;Exhibits;experience;Exposure to;FOXF1 gene;Future;Gases;Gene Delivery;gene therapy;Genes;Growth;Human;Hyperoxia;Impairment;improved;In Vitro;in vivo;Infant;injured;Injury;innovation;Laboratories;Life;Lung;Lung Diseases;lung injury;lung microvascular endothelial cells;lung regeneration;Modeling;Morbidity - disease rate;mortality;Mouse Embryonic Stem Cells;mouse model;Mus;nanoparticle;nanoparticle delivery;Natural regeneration;Neonatal;Neonatal Hyperoxic Injury;neonatal injury;Neonatal lung;neonatal lung injury;Notch Signaling Pathway;novel;Oxygen;Pathologic;Patients;PECAM1 gene;plasmid DNA;Plasmids;postnatal;preclinical study;Pregnancy;premature;Premature Birth;Premature Infant;premature lungs;preservation;pressure;prevent;progenitor;Proliferating;protein protein interaction;PTPRC gene;Pulmonary Circulation;pulmonary function;Pulmonary Hypertension;Rattus;recruit;repaired;Resolution;Respiratory Insufficiency;Respiratory physiology;Right Ventricular Hypertrophy;Severity of illness;STAT3 gene;Stat3 protein;stem cells;Structure;supplemental oxygen;Testing;Therapeutic;therapeutic nanoparticles;transcription factor;Transcriptional Regulation;Transplantation;Tube;vascular factor;Vascular remodeling;vector;ventilation

PROJECT_TITLE: Transcriptional Regulation of Endothelial Cells after Neonatal Lung Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-H(03)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative  Differentiation therapy is curative in one subtype of Acute Myeloid Leukemia (AML) and underexplored in the rest. We conducted gain-of-differentiation screens in AML models and identified that combined inhibition of LSD1 and MEN1 synergizes to induce terminal, potentially curative, differentiation in many AMLs. Validating the therapeutic efficacy of these pre-clinical differentiation therapy targets and determining the mechanisms of inhibitor-induced differentiation will change the principles of AML treatment strategies.

PI_NAMEs: CARRERA RODRIGUEZ, MARIA FERNANDA (contact)

PROJECT_TERMS: Accounting;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adopted;Automobile Driving;Biological Assay;Blood;CD86 gene;Cell Cycle;Cell Differentiation process;Cell model;Cells;Cellular Assay;Cessation of life;Characteristics;chemotherapy;ChIP-seq;Chromatin;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;cohort;combinatorial;Combinatorics;Combined Modality Therapy;CRISPR screen;CRISPR/Cas technology;cytotoxicity;Data;derepression;differential expression;Differentiated Gene;Differentiation Therapy;Disabling;Disease;Disease remission;Epigenetic Process;epigenomics;Experimental Models;experimental study;gene repression;Genes;Genomics;Hematopoietic Neoplasms;histological stains;histone demethylase;Human;Human Cell Line;improved;in vivo;Individual;inhibitor;interest;ITGAM gene;KDM1A gene;leukemia;Libraries;Malignant Neoplasms;Menin;Methodology;Methods;MLL-rearranged leukemia;Modeling;Molecular;mouse model;Mus;Myelogenous;Myeloid Progenitor Cells;novel;Oncogenes;Pathway interactions;Patients;pharmacologic;Pharmacologic Substance;Phenotype;preclinical efficacy;prevent;Prognosis;programs;Progranulocytes;Proliferating;Proteins;Regulation;Relapse;Reporting;Repression;Rest;Role;Sampling;self-renewal;small molecule;small molecule inhibitor;standard of care;stem;stemness;Surface;synergism;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Transcription Coactivator;transcription factor;Transcription Repressor;transcriptome sequencing;transcriptomics;transplant model;Treatment Efficacy;treatment strategy;Xenograft Model

PROJECT_TITLE: Differentiation-focused CRISPR Screen identifies LSD1 and Menin as combination therapy targets that induce terminal differentiation in AML


NIH_SPENDING_CATS: Cancer;Comparative Effectiveness Research;Prostate Cancer;Urologic Diseases

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative: Patients with metastatic castration-resistant prostate cancer (mCRPC) have poor prognosis (median overall survival = 3 years) due to the lack of effective or curative treatment options. Recent evidence has implicated metabolic reprogramming, especially related to glutamine and glutamate metabolism, as a major driver of mCRPC progression and drug resistance, but there are currently no treatments that capitalize on this metabolic vulnerability. The proposed research will validate druggable targets related to glutamine and glutamate metabolism in mCRPC both in vitro and in vivo for improved treatment efficacy and patient outcomes.

PI_NAMEs: HACKMAN, GABRELLE LAVENDER  (contact)

PROJECT_TERMS: acquired drug resistance;advanced prostate cancer;Allografting;alpha ketoglutarate;American;androgen deprivation therapy;androgen independent prostate cancer;androgen sensitive;Androgens;antiporter;Automobile Driving;Biomass;bone;Brain;Bypass;cancer cell;cancer diagnosis;cancer drug resistance;Cancer Etiology;cancer subtypes;cancer type;carbon skeleton;Caring;Castration;Cell Line;Cell Proliferation;Cells;Cessation of life;Chemicals;Chemoresistance;chemotherapy;Citric Acid Cycle;combinatorial;Combined Modality Therapy;common treatment;comparative efficacy;curative treatments;Cystine;Data;Development;Diagnosis;Disease;Distant;docetaxel;Drug resistance;Drug Synergism;druggable target;DU145;effective therapy;efficacy outcomes;Enzymes;Epigallocatechin Gallate;Essential Amino Acids;Event;Exhibits;experimental study;Formulation;Generations;Glutamate Dehydrogenase;Glutamate Metabolism Pathway;Glutamates;Glutaminase;Glutamine;Goals;Growth;Homeostasis;improved;improved outcome;In Vitro;in vivo;in vivo Model;inhibitor;insight;Kidney;Liver;lymph nodes;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metabolic;Metabolic Pathway;Metabolism;metabolomics;meter;Modeling;mortality;Mus;Neoplasm Metastasis;novel;novel therapeutic intervention;Nutrient;Oxidation-Reduction;Pathway interactions;Patient-Focused Outcomes;Patients;PC3 cell line;Pharmaceutical Preparations;Pharmacotherapy;Physiological;prevent;Probability;Process;Production;Prognosis;Proliferating;prostate cancer cell line;prostate cancer progression;Protein Isoforms;Reporting;Research;Resistance;resistance mechanism;Role;Signal Transduction Pathway;Site;stable isotope;standard of care;Survival Rate;synergism;Techniques;Testing;Therapeutic;Therapeutic Agents;therapeutically effective;Tissues;Tracer;Treatment Efficacy;Treatment outcome;treatment strategy;tumor growth;Validation;Work

PROJECT_TITLE: Targeting Metabolic Vulnerabilities with Synergistic Therapeutic Agents for Treatment of Metastatic Castration-Resistant Prostate Cancer.


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Genetics;Human Genome

ORG_CITY: Prairie View

ORG_DEPT: BIOLOGY

ORG_NAME: PRAIRIE VIEW AGRI & MECH UNIVERSITY

PHR: Project Narrative There is a need to promote diversity in genomics research, and opportunities for students an non-doctoral granting institutions. This proposal represents a collaboration between Prairie View A&M and Texas A&M to implement a genomics curriculum at Prairie View that includes a specialized series of courses and workshops aimed at promoting critical thinking, while immersing students in independent genomics research at Texas A&M.

PI_NAMEs: BLOCK, HARRIETTE  (contact)

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TERMS: Accountability;Active Learning;Address;African American student;Area;Assessment tool;Award;Bioinformatics;Biological Sciences;Biology;career;cohort;Collaborations;college;Critical Thinking;Databases;Doctor of Philosophy;Educational Curriculum;Educational process of instructing;Educational workshop;Effectiveness;empowerment;Evaluation;Event;experience;Exposure to;Faculty;faculty mentor;First Generation College Students;Fostering;Genes;genome sciences;Genomics;Graduate Education;graduate school preparation;graduate student;Grant;Hispanic-serving Institution;Hybrids;Institution;Intention;Investments;Journals;Lateral;Learning Module;Marketing;Measures;meetings;Mentors;Outcome;peer coaching;Population;Positioning Attribute;Process;programs;recruit;Research;Research Methodology;satisfaction;Science;Science, Technology, Engineering and Mathematics;Self Assessment;Series;skills;social;STEM field;Structure;Students;success;summer program;summer student;Texas;Training;training opportunity;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Students;United States;Universities;university student;Vision;Work

PROJECT_TITLE: GREAT: Collaborative Genomic Initiative between Prairie View A&M and Texas A&M Universities


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Many genetic variants have been associated with prostate cancer risk, but the functional mechanisms through which they mediate risk are unclear. Recent efforts have collected and analyzed large-scale functional genomic data (e.g., gene expression, isoform splicing) across a broad category of tissues, however this has primarily been performed in men of European ancestry which limits application to non-European men. Here, we propose to measure methylation, mRNA, proteins, and metabolites in prostate tissue for men of African and European ancestry and integrate them with ultra large-scale prostate cancer GWAS to characterize the genetic regulatory landscape of prostate cancer risk.

PI_NAMEs: MANCUSO, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: Achievement;African;African ancestry;Biological;Biological Assay;Biology;Cancer Biology;Cancer Etiology;cancer health disparity;cancer risk;Categories;Cessation of life;Chromosome Mapping;clinical phenotype;cohort;Data;Data Set;Death Rate;Disease;disease disparity;Disparity;DNA Methylation;Ethnic Origin;Ethnic Population;European;European ancestry;functional genomics;Gene Expression;Genes;Genetic;genetic information;Genetic Risk;genetic risk factor;genetic variant;Genome;genome wide association study;genome-wide;genomic data;Genomics;Genotype;Germ Lines;Goals;health disparity;Heterogeneity;improved;Incidence;Individual;insight;Investigation;Japanese;Latino;Lead;Malignant neoplasm of prostate;Maps;Measurement;Measures;Mediating;men;Messenger RNA;metabolomics;Methylation;Modeling;Molecular;molecular phenotype;Molecular Target;mRNA Expression;multi-ethnic;multiple omics;novel;novel strategies;Outcome;polygenic risk score;Population;Population Heterogeneity;predictive modeling;Procedures;Process;Prostate;Prostate Cancer Outcomes Study;prostate cancer risk;Prostatic Diseases;Prostatic Neoplasms;Protein Isoforms;Proteins;Proteomics;Quantitative Trait Loci;Resources;Risk;Risk Factors;risk variant;RNA Splicing;Sample Size;Screening for Prostate Cancer;screening guidelines;Statistical Methods;Subgroup;Susceptibility Gene;Testing;Tissues;Training;trait;Transcript;transcriptomics;Translating;Translations;Untranslated RNA;Variant;Work

PROJECT_TITLE: An integrative multi-omics approach to characterize prostate cancer risk in diverse populations

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: ALBANY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: Project Narrative According to the CDC, Periodontal disease effects 47.2% of people aged 30 and over; by the age of 65, the number of people impacted by the disease jumps to 70.1%. Shifts in the amount and species of bacteria that make up dental plaque are known to be the major cause of tooth decay. Our preliminary results suggest that the building blocks of dental plaque are small multispecies dental plaque aggregates left over from routine oral hygiene, a finding with potential clinical importance.

PI_NAMEs: LEMUS, ALEX  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Affect;Age;aged;Algorithms;Anaerobic Bacteria;Antibiotic Therapy;Bacteria;beta diversity;Biochemical;Biological Assay;Biological Models;Cell Communication;Cell Survival;Cells;Chemicals;Clinical;Communities;Complex;confocal imaging;Data;dental biofilm;Dental caries;Dental Hygiene;Dental Plaque;Development;differential expression;Disease;DNA sequencing;dysbiosis;Event;Excision;experimental study;Fluorescent in Situ Hybridization;Foundations;Genes;Genomics;Growth;Health;Human;human disease;Image;In Vitro;in vitro Model;Individual;Knowledge;Lead;Left;Mediating;member;Methods;microbial;Microbial Biofilms;microbial composition;microorganism;microscopic imaging;Modeling;Modernization;multiplexed imaging;Neighborhoods;Oral;oral biofilm;Oral cavity;oral microbiome;Periodontal Diseases;Periodontitis;Persons;preservation;Protocols documentation;Recurrence;Resolution;response;Role;Saliva;Sampling;spectrograph;Structure;Structure-Activity Relationship;Surface;surface coating;System;Taxon;Taxonomy;Testing;tooth surface;virtual;Work

PROJECT_TITLE: Multispecies aggregates from human dental plaque nucleate highly diverse spatially structured oral biofilms on saliva coated surfaces

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative (Public Health Relevance Statement) In the era of precision medicine, large biobank cohorts are resources of increasing importance. The aim of the project is to develop and evaluate accurate and efficient methods and tools for detecting Identity- by-Descent (IBD) segments in such cohorts. If successful, these new informatics methods will enable the community to better leverage the genetic relationships in large genotyped cohorts for genetic discovery.

PI_NAMEs: ZHANG, SHAOJIE ;ZHI, DEGUI  (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Address;Algorithms;Award;Behavior;Benchmarking;biobank;cohort;Communities;Data;data structure;Detection;detection method;Ethnic Origin;Event;flexibility;Frequencies;Gene Frequency;General Population;Generations;Genetic;Genetic Recombination;Genetic Research;Genome;Genomic Segment;Genotype;Haplotypes;Human;Human Genetics;identity by descent;improved;Individual;Informatics;informatics tool;innovation;insight;Intuition;Length;Maps;method development;Methods;Output;Pattern;Population;Population Study;precision medicine;Process;public health relevance;Publishing;Recording of previous events;Research;Resources;Running;Sample Size;Sampling;Scanning;Signal Transduction;success;tool;Translating

PROJECT_TITLE: Scalable methods for identity by descent

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: RIXENSART

ORG_COUNTRY: BELGIUM

ORG_FIPS: BE

ORG_NAME: GLAXOSMITHKLINE BIOLOGICALS

PHR: Project Narrative – Development of Robust and Low-cost Vaccines Against Salmonella Paratyphi A: Enteric infections due to Salmonella Paratyphi A are a critical health issue, with high prevalence in lower- and middle- income countries. Vaccines targeting Salmonella Typhi have been successful, however there are currently no licensed vaccines against S. Paratyphi A. The proposed work will result in the development and scale-up of two Pan-Salmonella vaccines that protect against S. Paratyphi A infection.

PI_NAMEs: CANALS ALVAREZ, ROCIO  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: 5 year old;Advanced Development;Affinity;Africa;Animal Model;Antibodies;Antigens;Asia;bactericide;Biological;Cause of Death;Cessation of life;Classification;Clinical Research;Clinical Trials;cost;cross reacting material 197;Data;Development;diarrheal disease;Dose;Effectiveness;Enteral;enteric infection;experimental study;Fever;foodborne illness;Formulation;Funding;Future;gastrointestinal;global health;Glycoconjugates;Goals;good laboratory practice;Good Manufacturing Process;Gram-Negative Bacteria;Grant;Health;High Prevalence;Human;Immune response;immunogenicity;improved;Individual;Infection;Investigational Drugs;Lead;Licensing;Life;low and middle-income countries;manufacture;manufacturing process;Measures;Membrane;Modeling;Mus;Oryctolagus cuniculus;Paratyphoid Fever;Pharmaceutical Preparations;Phase;phase 1 study;pre-clinical;preclinical evaluation;preclinical study;prevent;Process;Production;research clinical testing;Safety;Salmonella;Salmonella enterica;Salmonella paratyphi;Salmonella typhi;Salmonella typhimurium;Salmonella Vaccines;Sampling;scale up;Series;Structure;Technology;Testing;Toxic effect;Toxicology;vaccine candidate;vaccine safety;Vaccines;Vesicle;Work


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: OVERALL – PROJECT NARRATIVE Advanced technologies in radiation therapy and the higher cost of proton therapy have engendered the need to accurately compare photon and proton radiation treatment modalities based on their clinical effectiveness to facilitate the improved selection of the optimum modality for cancer radiotherapy. As a follow up to our previous MD Anderson and Massachusetts General Hospital collaborative program projects, which explored the clinical applicability of proton therapy, in the proposed joint program project we will investigate the unique physical, biological and immunomodulatory properties of proton therapy vs. photon therapy and apply the knowledge thus gained to develop precision medicine techniques to identify the patients most likely to benefit from protons and optimize proton and photon therapy to maximize their effectiveness. This approach is a marked paradigm shift from the conventional assumption that improved dosimetry alone or population-based (as opposed to precision medicine) techniques will lead to better outcomes with protons in unselected patients and reframes the discussion for how patients should be assigned to a particular modality and their treatments optimized.

PI_NAMEs: HONG, THEODORE S (contact);MOHAN, RADHE

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: Achievement;Advanced Development;adverse outcome;Affect;Articulation;Biological;Biological Factors;Biological Markers;Biometry;Cancer Center;cancer radiation therapy;cancer therapy;Characteristics;Clinical;clinical application;Clinical effectiveness;Collaborations;Complication;cost;Data;data management;design;Development;Disparate;Dose;dosimetry;Effectiveness;Equilibrium;Esophagus;follow-up;General Hospitals;genomic biomarker;Genomics;Genotype;Glioma;Goals;Heterogeneity;Human;imaging biomarker;Immune system;Immunologic Factors;Immunologics;immunoregulation;Immunosuppression;improved;individual patient;Intensity modulated proton therapy;Joints;Knowledge;Liver;Lymphopenia;Malignant Neoplasms;Massachusetts;Methods;Modality;Modeling;National Clinical Trials Network;Normal tissue morphology;Oncology;Outcome;Patient Selection;Patient-Focused Outcomes;Patients;Pattern;personalized approach;Photons;Population;population based;potential biomarker;precision medicine;Prediction of Response to Therapy;predictive modeling;Program Research Project Grants;programs;Property;proton beam;Proton Radiation;proton therapy;Protons;Radiation;Radiation Dose Unit;radiation mitigation;Radiation Oncology;Radiation therapy;Randomized;randomized trial;Relative Biological Effectiveness;Research;Resources;response;Risk;Risk Factors;Role;Side;Statistical Models;Techniques;Technology;Therapeutic;therapy design;Therapy trial;Toxic effect;treatment optimization;tumor;Uncertainty

PROJECT_TITLE: Integrating patient-specific clinical and biological factors towards individualizing utilization of proton and photon radiation therapy.


NIH_SPENDING_CATS: Cancer;Cardiovascular;Clinical Research;Heart Disease;Patient Safety;Precision Medicine;Radiation Oncology

PHR: PROJECT 1 – NARRATIVE We propose novel approaches to understand the differences in normal tissue toxicities between protons and photons and to advance precision medicine concepts to proton radiotherapy by identifying patients that will benefit from this modality.

PI_NAMEs: PAGANETTI, HARALD  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Biological;Biological Factors;Biological Markers;biomarker identification;Blood;Brain;Brain Stem;Cardiotoxicity;Cardiovascular system;Charge;Clinical;Clinical Data;Clinical Trials;Common Terminology Criteria for Adverse Events;Complication;Consensus;conventional therapy;Disease;Dose;Educational workshop;falls;Frequencies;Functional disorder;Grant;Heart failure;Hepatotoxicity;Image;imaging biomarker;Immune response;Institution;irradiation;Joints;Knowledge;Machine Learning;Modality;Modeling;Myocardial dysfunction;Myocardial Infarction;Necrosis;Noise;Normal tissue morphology;novel;novel strategies;Organ;Outcome;particle;Patient Selection;patient stratification;Patients;Photons;Positron-Emission Tomography;precision medicine;Probability;proton beam;Proton Radiation;proton therapy;Protons;Radiation;radiation risk;Radiation therapy;Radiation Tolerance;Radiobiology;Relative Biological Effectiveness;Research;response;Risk;Site;Statistical Models;System;Toxic effect;Treatment outcome;treatment site;Treatment-related toxicity;tumor;two-dimensional;University of Texas M D Anderson Cancer Center;Variant

PROJECT_TITLE: Project 1: Understanding normal tissue toxicity to identify patients most likely to benefit from proton therapy.


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: LIVERMORE

ORG_NAME: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC

PHR: PROJECT NARRATIVE The National User Resource for Biological Accelerator Mass Spectrometry (User Resource) will provide ultra-sensitive Carbon-14 isotopic analysis by accelerator mass spectrometry (AMS) for NIH-funded researchers. The User Resource will enable a deeper understanding of the etiology of human health concerns by enabling quantification of pharmacokinetics and other molecular endpoints directly in humans; offering the ability to conduct quantitative studies using biologics such as proteins or lipids; and enabling more relevant studies of metabolic pathways in health and disease through the use of much lower, more biologically-relevant, concentrations of metabolic substrates in cells and intact organisms. The User Resource will increase the accessibility and visibility of ultra-sensitive 14C measurements by training new investigators and expanding the National user base while concurrently improving the efficiency of AMS measurements through installation of new interfaces, technical modifications to ion sources and upgrades to data analysis software for improved ease of use and data reporting.

PI_NAMEs: BENCH, GRAHAM  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: accelerator mass spectrometry;Address;Animal Model;Area;Award;base;Biochemistry;Biological;Biological Models;Biological Products;Biological Sciences;Biomedical Research;Biomedical Technology;Biophysics;Budgets;C14 isotope;carcinogenesis;Cells;Cellular biology;Code;Communities;Complex;Computer software;Data Analyses;Data Reporting;detection limit;Development;Developmental Biology;Disease;drug development;Drug Kinetics;Environment;Etiology;Funding;Gases;Genetic;Goals;Grant;Health;Human;improved;in vivo;ion source;Isotopes;Label;Laboratories;Lipids;mass spectrometer;Mass Spectrum Analysis;Measurement;Measures;Metabolic;metabolic abnormality assessment;Metabolic Pathway;metabolic rate;Metabolism;Methods;Modeling;Modification;Molecular;Molecular Biology;National Institute of General Medical Sciences;nutrition;operation;Organism;Pathway interactions;Pharmacology;Physiological;Physiology;programs;Property;Proteins;Radioisotopes;Radiolabeled;Research;Research Personnel;research study;Research Support;Resource Development;Resources;Risk Assessment;Safety;Sampling;Science;Scientist;Services;System;Technology;Therapeutic;tool;toxicant;Toxicology;Training;United States;United States National Institutes of Health;Work;Workforce Development;Xenobiotic Metabolism


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: PROJECT NARRATIVE Patients diagnosed with Barrett’s esophagus have a more than 30-fold higher risk of developing esophageal adenocarcinoma (EAC) than the average person, and thus are advised to undergo follow-up examinations for early detection of EAC when it can be removed. With current clinical measurements, however, it is impossible to discern which patients are most likely to develop EAC versus the >90% who will never get this rare but deadly cancer. In efforts to solve this public health question, we aim to interrogate the entirety of Barrett’s tissue, measure how it evolves over time in patients, and look for clues in these “tissue maps” to better decide who needs preventative action and who can live their life with less worry and intensive surveillance.

PI_NAMEs: CURTIUS, KATHLEEN M. (contact)

PROGRAM_OFFICER_NAME: RICHMOND, ELLEN S

PROJECT_TERMS: Address;Adenocarcinoma In Situ;Age;age acceleration;Aging;Automobile Driving;Barrett Esophagus;Biological;biological age;Biological Assay;Biological Markers;Calibration;cancer risk;carcinogenesis;Case/Control Studies;Cells;Clinical;clinical care;Clonal Evolution;Clonal Expansion;cohort;colonic crypt;Computer Models;cost;Data;data-driven model;design;Development;Diagnosis;DNA methylation profiling;DNA sequencing;Early Diagnosis;epigenetic clock;Epigenetic Process;Esophageal Adenocarcinoma;Esophageal Tissue;Esophagus;Evolution;experimental study;follow-up;Future;Genetic;Genetic Markers;Genome;genomic data;Genomics;Gland;Goals;Growth;high risk;human tissue;improved;Individual;innovation;insight;Intervention;Lesion;Life;Malignant Neoplasms;Maps;Matched Group;mathematical model;Mathematics;Measurement;Measures;Methylation;Microdissection;Modeling;models and simulation;Molecular;molecular marker;Molecular Profiling;multi-scale modeling;multiple omics;Mutation;Natural History;neoplastic;Outcome;outcome forecast;patient population;Patient-Focused Outcomes;Patients;Performance;Persons;Phylogenetic Analysis;Population;predictive modeling;premalignant;Probability;Procedures;Prognostic Marker;progression risk;prospective;Public Health;reconstruction;Recording of previous events;Research;Resolution;Risk;Sampling;screening;Screening for cancer;Somatic Mutation;spatiotemporal;stem cell replacement;stem cells;surveillance strategy;Targeted Resequencing;Testing;Time;tissue mapping;Tissue Sample;Tissues;TP53 gene;Translating;tumor progression;Update;Work

PROJECT_TITLE: Multiscale modeling of spatiotemporal evolution in Barrett's esophagus

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]