NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Clinical Research;Substance Misuse

ORG_CITY: CHARLESTON

PI_NAMEs: BECKER, HOWARD C. (contact)

PROJECT_TERMS: Advertisements;Advertising;Alcohol dependence;alcohol exposure;alcohol research;Animals;Basic Science;Biostatistics Core;Cells;Chronic;Clinical;Clinical Research;cohesion;Data Analyses;data management;Databases;Dependence;design;Development;DNA Library;Effectiveness;Enrollment;Environment;Ethanol;Ethanol dependence;Evaluation;Exposure to;Fiber;Fostering;Genotype;Histologic;improved;Individual;Intake;Intervention;Manuscripts;Medical;Mission;Modeling;Modification;Molecular;Monitor;mouse model;Mus;Operative Surgical Procedures;optogenetics;Participant;Pharmaceutical Preparations;Photometry;Pilot Projects;Play;power analysis;Preparation;Procedures;Productivity;Protocols documentation;Quality Control;recruit;Reproducibility of Results;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Role;Sampling;screening;Self Administration;Services;Standardization;statistical service;Study Subject;Techniques;Technology;tool;Training;treatment center;Validation;Virus;Work

PROJECT_TITLE: Shared Resource Core


ADMINISTERING_IC: ES

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Effects of Indoor Air Pollution;Lung;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative We are proposing to develop and test affordable high surface area carbonaceous hybrid materials fabricated from natural-fibers, industrial carbon fiber waste and vegetable precursor textile fibers for removal of heavy metals (Cd, As, Mn) from contaminated soil and for household air filtration. We will optimize and tailor the fibers to obtain sorbent mats and filters to be used in these applications. The research proposed here will advance the material science and engineering domain with knowledge gain to be applicable for environmental remediation.

PI_NAMEs: LUNGU, CLAUDIU T (contact)

PROJECT_TERMS: Adsorption;Affect;Affinity;Air;air filtration;Air Pollution;Aircraft;Alabama;Architecture;Area;Banana;Biomass;Carbon;carbon fiber;Cause of Death;Cellulose;chemical group;Chemicals;Chemistry;Chronic Obstructive Pulmonary Disease;clinical database;coal-fired power plant;Coke;Collaborations;Communities;Complex;Containment;cost;Data;Data Analyses;data management;Dental Pulp;Derivation procedure;design;Development;disease registry;Dust;Engineering;Environment;Environmental Health;Evaluation;Excision;Exposure to;fabrication;Fiber;field study;Filtration;Flax;flexibility;Gases;Geometry;Goals;Hazardous Substances;Health;Heavy Metals;Hemp;High Prevalence;Home;Household;Human Activities;Hybrids;improved;Industrialization;Industry;Inhalation;innovation;Iron;Knowledge;Kudzu;Laboratories;Lasers;Lead;Lignin;Lung Diseases;manufacture;Maps;materials science;Measures;Metals;Methods;Microscopic;Mining;Morphology;multidisciplinary;nano;Neighborhoods;novel;operation;Outcome;particle;Particulate Matter;Poison;pollutant;Pollution;Porosity;Prevalence;Process;Production;Property;prototype;Quality of life;Recycling;remediation;Research;Research Personnel;Research Project Grants;Risk;Risk Assessment;Site;smoking prevalence;Soil;soil pollution;Source;Spectrum Analysis;Sports;Steel;superfund site;Surface;Suspensions;Technology;Testing;Textiles;Translating;Translational Research;Translations;Universities;vapor;Vegetables;wasting;Water;Water Pollution;Wood material;Work

PROJECT_TITLE: Project 5 Nano-micro Hybrid Fibrous Materials for Containment Removal and Site Remediation


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Suicide;Suicide Prevention

ORG_CITY: HADLEY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Among the top preventable causes of death, suicide is arguably the most preventable as it is the result of a voluntary act, yet our ability to prevent suicide remains rudimentary and ineffective as evidenced by escalating rates across nearly every state, age range, and demographic cluster. Identifying proximal suicide risk markers will inform our ability to detect and ultimately intervene prior to an individual acting on suicidal thoughts. NIH’s mission will be served by the proposed study through improving the prediction of suicidal behaviors in high-risk populations and informing prevention efforts, ultimately reducing suffering and mortality with substantial societal cost.

PI_NAMEs: DIXON-GORDON, KATHERINE LEE (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Accident and Emergency department;Accounting;Affective;Age;Arousal;Award;Behavior;behavior measurement;Behavior Therapy;biomarker identification;Borderline Personality Disorder;Cause of Death;Cessation of life;Clinical;clinical risk;Cognitive;cognitive process;Complex;Computer Models;Data;Decision Making;Distal;Ecological momentary assessment;Emotional;Emotions;Evaluation;experience;Feedback;Feeling suicidal;follow-up;Functional disorder;Future;Goals;Health;high risk;high risk population;Impairment;improved;indexing;Individual;innovation;Intervention;Joints;Knowledge;Laws;Learning;Learning Difficulty;Life;Link;Maps;Measures;Medical;Methods;mindfulness;Mission;Modeling;morphogens;mortality;Nature;novel;Outcome;Participant;Patient Self-Report;Patients;Pattern;Persons;Physiological;Populations at Risk;Prevention;Process;prospective;Psychiatry;Psychological reinforcement;Psychopathology;Punishment;recruit;reducing suicide;remediation;Research;response;Rewards;Risk;Risk Factors;Risk Marker;Sampling;Severities;societal costs;suicidal;suicidal act;suicidal behavior;suicidal individual;suicidal patient;suicidal risk;Suicide;Suicide prevention;suicide rate;Testing;therapy development;Time;United States National Institutes of Health;Work

PROJECT_TITLE: EMERGE: Ecological Momentary Evaluation of Responses to Gain/Loss and Emotions

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Kidney Disease;Nutrition;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Hereditary hypophosphatemic disorders caused by inactivating mutations of Phex and Dmp1 are characterized by elevated serum FGF23 levels and hypophosphatemia leading to impaired skeletal growth and mineralization. These alterations in bone and mineral metabolism are thought to be the direct consequence of impaired PHEX and DMP1 interaction in bone. This project proposes to test whether the interaction between PHEX and DMP1 in the kidney prevents FGF23-induced phosphaturia, thus providing novel potential therapeutic targets in diseases associated with altered phosphate homeostasis.

PI_NAMEs: MARTIN, ALINE C (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: absorption;Animals;Antibodies;autosome;Blocking Antibodies;bone;Bone Growth;bone loss;Bone Pain;Cells;Data;Defect;defined contribution;Dentin;dentin matrix protein 1;Diet;dietary;Disease;Endopeptidases;Equilibrium;Excretory function;Familial hypophosphatemic bone disease;fibroblast growth factor 23;Fibroblast Growth Factor Receptors;Fracture;Functional disorder;Genes;Genetic;Goals;Growth;Homeostasis;Hormones;Human;Hypophosphatemia;Impairment;improved;improved outcome;In Vitro;in vivo;Inherited;Injections;innovation;inorganic phosphate;Intake;Intestines;Kidney;Kidney Transplantation;Link;Mediating;Metabolism;mineralization;Minerals;Modification;Mus;mutant;Mutant Strains Mice;Mutation;novel;novel therapeutic intervention;novel therapeutics;Osteoblasts;Osteocytes;Osteomalacia;overexpression;Pathogenesis;Phenotype;Physiologic calcification;prevent;Production;Productivity;Protein Deficiency;protein function;Proteins;Recurrence;Regulation;Renal function;Reporting;Repression;response;Role;Serum;Signal Transduction;skeletal;soft tissue;Supplementation;Testing;therapeutic target;Time;Tissues;Transplant Recipients;Tubular formation;Universities;urinary;wasting;Wild Type Mouse;Work

PROJECT_TITLE: The role of DMP1 in FGF23-induced hypophosphatemia

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: CORE NARRATIVE – ADMINISTRATIVE CORE Polycyclic aromatic hydrocarbons (PAHs) are some of the most common toxic chemicals found at the nation's superfund sites. Our Center goal is to help the research and regulatory communities protect human health and the environment. The Administrative Core (AC) provides a supportive infrastructure and culture that focuses our investigators on addressing the SRP Mandates.

PI_NAMEs: TANGUAY, ROBYN L (contact)

PROJECT_TERMS: Address;Advisory Committees;Aromatic Polycyclic Hydrocarbons;catalyst;Chemicals;commercialization;Communication;Communities;Disasters;Ensure;Environment;Event;evidence base;Extramural Activities;Funding;Goals;Government Agencies;Grant;Health;Human;Hurricane;Infrastructure;innovation;Institution;Investments;Knowledge;Laboratories;Leadership;member;Mission;multidisciplinary;National Institute of Environmental Health Sciences;new technology;Oregon;Pacific Northwest;Poison;Posture;Productivity;programs;Qualifying;Recording of previous events;Research;Research Personnel;Resources;Risk;Signal Recognition Particle;Specific qualifier value;Strategic Planning;superfund site;Technology Transfer;tool;Toxic effect;Translational Research;Translations;tribal Nation;Universities;Vision

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

PHR: CORE NARRATIVE – DATA MANAGEMENT AND ANALYSIS CORE The Data Management and Analysis Core (DMAC) develops an integrated data management plan for the entire SRP. The DMAC facilitates data sharing and interoperability through custom software solutions and advanced data science to enable integration of data from biomedical research projects and environmental science and engineering projects. The DMAC implements best practices for statistically-robust experimental design, data pipelines, data integration, and data management to characterize the chemical identity and toxicities of PAHs commonly found at Superfund Sites, and to elucidate the links between exposures and disease.

PI_NAMEs: WATERS, KATRINA M. (contact)

PROJECT_TERMS: analysis pipeline;analytical tool;Bioinformatics;Biological;Biological Models;biological systems;Biomedical Research;Chemicals;Computer software;Custom;Data;Data Analyses;Data Analytics;data dissemination;data integration;data interoperability;data management;Data Management Resources;data pipeline;data quality;Data Science;Data Set;data sharing;data standards;data streams;data visualization;deep learning algorithm;Descriptor;Development;Discipline;Disease;diverse data;Dose;Ensure;Environmental Engineering technology;Environmental Science;Experimental Designs;Exposure to;FAIR principles;Feedback;Fostering;Generations;Goals;Guidelines;Hazardous Substances;Health;Human;improved;innovation;interoperability;Life;Life Cycle Stages;Link;Metadata;Mission;Modeling;Molecular;multidisciplinary;new technology;next generation;novel;operation;Outcome;phenotypic data;prevent;Procedures;Process;programs;Publications;quality assurance;Quality Control;Research;Research Project Grants;Research Support;response;Risk;Risk Assessment;Sampling;Scientific Advances and Accomplishments;sharing platform;Software Engineering;Software Tools;statistics;Structure;Superfund;superfund site;Techniques;timeline;tool;Toxic effect;Toxicology;Training;Work

PROJECT_TITLE: Data Management & Analysis Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Prevention;Racial and Ethnic Minority Health Research;Rural Health

PHR: CORE NARRATIVE – COMMUNITY ENGAGEMENT CORE The Community Engagement Core (CEC) will respond to the concerns of communities impacted by hazardous substances and identifying effective public health intervention and prevention strategies that reduce the amount and toxicity of PAHs and other harmful substances. We will partner with the Swinomish Indian Tribal Community, the Confederated Tribes of the Umatilla Indian Reservation, the U.S. Army Corps of Engineers Pine Meadow Campground, and citizens who live adjacent to the Portland Harbor Superfund Site. Our primary objective is to identify and evaluate strategies that promote public health and reduce the amount and toxicity of PAHs and other hazardous substances in diverse communities.

PI_NAMEs: ROHLMAN, DIANA  (contact)

PROJECT_TERMS: Affect;Air;Aromatic Polycyclic Hydrocarbons;Awareness;Biomedical Engineering;Black race;Chemical Exposure;Chemicals;Collaborations;Communication;Communities;community based participatory research;community based research;community engaged research;community engagement;Community Participation;Compensation;cultural competence;Data;Decision Making;design;Educational process of instructing;empowerment;Engineering;Environment;Environmental Engineering technology;Environmental Hazards;Exposure to;Food;Fostering;Goals;Grant;hazard;Hazardous Substances;Health;Home;Human;improved;Indian reservation;Individual;Intervention;Knowledge;knowledge integration;Learning;Marine Sediment;Measures;Mission;mutual learning;Natural Resources;new technology;novel;Oregon;Outcome;Persons;Pollution Prevention;prevent;Prevention strategy;programs;Public Health;public health intervention;Religion;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;response;Risk;Risk Reduction;Silicones;Specific qualifier value;Superfund;superfund site;Surveys;Swinomish;System;Toxic effect;toxicant;Treaty;tribal community;Tribes;Trust;Umatilla;Universities;Visit;Work;wristband

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Bioengineering

PHR: CORE NARRATIVE – CHEMICAL MIXTURES CORE The Chemical Mixtures Core develops new analytical methods and provides robust and sensitive analytical methods for substituted PAHs, PAH degradation products and co-contaminants at Superfund sites. The CMC creates PAHs mixtures, PAH real-world Superfund reference materials, and provides standards and dosing solutions for the SRP. The CMC provides all analytical methods through technology transfer to SRP laboratories and interested stakeholders.

PI_NAMEs: ANDERSON, KIM A. (contact)

PROJECT_TERMS: Air;Analytical Chemistry;analytical method;aquatic organism;Aromatic Polycyclic Hydrocarbons;Astacoidea;Biological;Biological Availability;Biological Markers;Cell Culture Techniques;Certification;chemical property;Chemicals;Chemistry;Clams;Collaborations;Collection;Communities;Complex;cost;cost effective;Creativeness;Data;Data Analyses;data management;detection limit;Development;Devices;Dose;E-learning;empowerment;Evaluation;Fishes;Food;Forensic Medicine;Goals;Health;Human;improved;instrument;interest;Investigation;Isomerism;Knowledge;Label;Laboratories;large datasets;Lung;Methods;molecular mass;multiple reaction monitoring;new technology;Nitrogen;Oxygen;Parents;Plasma;Process;Production;programs;remediation;repository;Research;Research Personnel;Resources;Risk;Risk Assessment;Salmon;Sampling;screening;Serum;Services;Signal Recognition Particle;Smoke;Soil;Solid;Solvents;Source;Superfund;superfund site;Technical Expertise;Techniques;Technology;Technology Transfer;Testing;Tissues;volatile organic compound;Volatilization;Water;web based interface;web platform;Zebrafish

PROJECT_TITLE: Chemical Mixtures Core


PI_NAMEs: HARPER, STACEY L (contact)

PROJECT_TERMS: Achievement;Articulation;Award;Biological;Biomedical Engineering;career;Chemistry;cohort;Communication;Communities;community engagement;Competence;Complex;Complex Mixtures;cultural competence;Data Analyses;data management;data sharing;Development;Development Plans;Discipline;Education;Educational workshop;Ensure;environmental chemistry;Environmental Engineering technology;Environmental Health;Environmental Science;Evaluation;experience;Exposure to;externship;Fellowship;flexibility;Funding;Future;General Population;Goals;Grant;Health;Individual;Institution;Joints;Journals;Laboratories;Lead;Leadership;Learning;Molecular;Molecular Mechanisms of Action;Molecular Toxicology;Monitor;Motivation;multidisciplinary;new technology;next generation;Oregon;Outcome;Outcomes Research;Pacific Northwest;Performance;Pilot Projects;Postdoctoral Fellow;pre-doctoral;Problem Solving;programs;Public Health;recruit;Reporting;Research;Research Project Grants;Research Support;Resources;response;responsible research conduct;Risk;Risk Assessment;Scientist;Self Assessment;self-directed learning;Signal Recognition Particle;skills;success;Superfund;superfund site;symposium;Toxicology;Training;Training Activity;training opportunity;Training Programs;translational engagement;Translational Research;United States National Institutes of Health;Universities;uptake;Work

PROJECT_TITLE: Research Experience and Training Coordination Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Climate-Related Exposures and Conditions;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

PHR: The cause for the late-onset Alzheimer’s disease (LOAD), which accounts for > 95% of AD cases, is unknown. In this project, we will test a novel hypothesis that O3 exposure synergizes with aging and APOE4 leading to LOAD in a sex-dependent manner. The results from these studies will not only shed new lights on the etiology of LOAD but may also lead to the development of novel strategies for the prevention and treatment of this devastating disease.

PI_NAMEs: LIU, RUI-MING  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Address;Affect;Age;Aging;air filter;Alleles;Alzheimer's Disease;antioxidant enzyme;Antioxidants;apolipoprotein E-3;apolipoprotein E-4;Brain;Budgets;Complex;Data;Development;Dietary Supplementation;Disease;disease model;Elderly;Environmental Exposure;Environmental Risk Factor;epidemiology study;Estrogens;Etiology;Exhibits;exposed human population;Exposure to;Female;Functional disorder;genetic risk factor;Genotype;high risk;Human;Hydroquinones;Incidence;insight;Late Onset Alzheimer Disease;male;Memory impairment;Memory Loss;Modification;Molecular;Mus;neuroinflammation;neurotoxicity;novel;novel strategies;nuclear factor-erythroid 2;Oxidants;oxidation;Oxidative Stress;Ozone;ozone exposure;Periodicity;Plasma;Play;pollutant;Population;Predisposition;Prevention strategy;Proteins;Protocols documentation;Resistance;response;restoration;Risk;Risk Factors;Role;sex;Sex Differences;synergism;Testing;Time;Toxic effect;Toxic Environmental Substances;toxicant

PROJECT_TITLE: Sex-dependent synergy between O3 exposure, APOE4 e4 genotype, and aging in the onset of Alzheimer's disease

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Heart failure with reduced ejection fraction represents a significant public health burden in the United States. Although effective therapies exist, gaps in their adoption contribute substantially to excess morbidity and mortality. The “polypill” represents a potential strategy for simplifying the adoption of proven heart failure therapies. We propose a practical, single-center randomized trial to test the feasibility and effectiveness of a polypill-based strategy for the treatment of heart failure in a low-income, racially-diverse population.

PI_NAMEs: PANDEY, AMBARISH  (contact);WANG, THOMAS J.

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: Address;Adherence;Adoption;Adrenergic beta-Antagonists;Adult;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;antagonist;barrier to care;Blood Pressure;cardiac magnetic resonance imaging;cardiovascular disorder prevention;Cardiovascular system;Caring;Clinical;Combination Medication;Communities;Conduct Clinical Trials;cost;County Hospitals;Disease;Dose;effective therapy;Effectiveness;Eligibility Determination;Enrollment;evidence base;experience;feasibility testing;follow-up;Formulation;Glucose;Guidelines;Health;Health Insurance;Heart failure;heart failure with reduced ejection fraction;heart imaging;Hospitalization;Hospitals;imaging modality;improved;Individual;inhibitor;LDL Cholesterol Lipoproteins;Left;Left Ventricular Ejection Fraction;Low income;Low Income Population;low socioeconomic status;Medicaid;Medical;medication compliance;Metoprolol Succinate;Mineralocorticoid Receptor;Morbidity - disease rate;mortality;Neprilysin;older adult;Outcome;Participant;Patient Care;patient population;Patients;Pharmaceutical Preparations;pill;Population;Population Heterogeneity;pragmatic trial;Prevalence;primary endpoint;Primary Prevention;pro-brain natriuretic peptide (1-76);Provider;Public Health;Quality of life;racial disparity;racial diversity;Randomized;randomized trial;Regimen;Registries;Renin-Angiotensin System;Reproducibility;Risk Factors;secondary outcome;Secondary Prevention;socioeconomic disparity;Sodium;Spironolactone;System;Testing;Texas;Therapeutic;Time;Titrations;treatment as usual;Treatment Failure;treatment strategy;Underinsured;Uninsured;United States;uptake;Ventricular;Visit;Walking

PROJECT_TITLE: Polypill strategy for the evidence-based management of heart failure with reduced ejection fraction in an underserved patient population

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


PHR: PROJECT NARRATIVE – TILTON PROJECT Critical data gaps exist in understanding toxicity for the broader class of structurally diverse, substituted PAHs along with knowledge of how PAHs contribute to toxicity of mixtures. Our proposal overcomes these critical insufficiencies and addresses stakeholder needs to improve PAH risk assessments. The outcomes of these studies will be used to assess and communicate human health risk and evaluate susceptibility for relevant populations.

PI_NAMEs: TILTON, SUSAN C (contact)

PROJECT_TERMS: 3-Dimensional;Address;adverse outcome;Air;Asthma;Benchmarking;Biological;Biological Markers;bronchial epithelium;Cell Adhesion;Cell Differentiation process;Cells;Chemical Exposure;Chemical Models;Chemicals;Code;Communication;Communities;Complex;Complex Mixtures;CYP1B1 gene;cytotoxicity;Data;Dermal;detection method;diagnostic tool;Diet;Disease;Disease susceptibility;Dose;Environmental Health;enzyme activity;Enzymes;Evaluation;experimental study;exposure route;Exposure to;gene environment interaction;Gene Expression;Genetic Polymorphism;genetic variant;genotoxicity;Goals;GSTM1 gene;hazard;Hazard Assessment;Hazardous Substances;Health;Human;improved;In Vitro;in vivo;Individual;Inflammation;Inhalation;innovation;Knowledge;Link;Liquid substance;Lung;Measures;Messenger RNA;Metabolic;Metabolism;Methods;MicroRNAs;Modeling;Mus;new technology;Outcome;Outcome Study;Oxidative Stress;Pathogenesis;Pathway interactions;Phase;Phenotype;Population;Predisposition;Proteins;Proteomics;remediation;Research;Research Project Grants;respiratory;Respiratory Disease;response;Risk;Risk Assessment;Risk Estimate;Role;Science;Signal Recognition Particle;superfund site;Systems Biology;Techniques;Technology;Testing;three dimensional cell culture;Toxic effect;Toxicity Tests;transcriptome sequencing;Untranslated RNA;uptake

PROJECT_TITLE: Linking PAH Exposure to Health Outcomes Using Human Primary In Vitro Respiratory Model


PHR: PROJECT NARRATIVE – TEEGUARDEN PROJECT This project will produce transformative tools that dramatically improve researcher ability to measure metabolic potential and chemical distribution, to quantify these molecular determinants of susceptibility in test systems and to compare the results with analogous measurements in humans. Two innovations, activity-based proteomic probes, and multi-modal chemical microscopy, will open new scientific horizons in the understanding of molecular determinants of differential susceptibility. The impact will be translatable modeling of PAH exposure effects on metabolism and distribution that directly inform our stakeholders in environmental remediation and public health.

PI_NAMEs: SMITH, JORDAN NED (contact)

PROJECT_TERMS: 3-Dimensional;Address;Aromatic Polycyclic Hydrocarbons;Biological Assay;Body Composition;bronchial epithelium;bropirimine;Cell Culture Techniques;Chemicals;Communities;Complex;Consumption;cost;Cytochrome P450;Data;Detection;detection method;Dose;dosimetry;Drug Metabolic Detoxication;Drug or chemical Tissue Distribution;Embryo;Environmental Exposure;enzyme activity;Enzymes;Epithelial Cells;Evaluation;expectation;exposed human population;exposure pathway;Expression Profiling;Foundations;Genes;Glucuronosyltransferase;Glutathione S-Transferase;Goals;hazard;Hazardous Substances;Health;health assessment;Human;improved;Incubated;Individual;innovation;knock-down;Knock-out;Laboratory Research;Lead;Lipids;Lung;Measurable;Measurement;Measures;Metabolic;metabolic rate;Metabolism;Methods;Microscopy;model organism;Modeling;Molecular;multimodality;Nature;new technology;novel;overexpression;pharmacokinetic model;Physiological;Predisposition;Prevalence;Process;Property;Proteins;Proteome;Proteomics;Public Health;remediation;Research;Research Personnel;Risk;Risk Assessment;Sampling;Signal Recognition Particle;Site;Substrate Specificity;superfund site;System;Techniques;Testing;Time;Tissue Sample;Tissues;tool;Toxic effect;toxicant;Toxicant exposure;Toxicity Tests;Translating;Water;Work;Zebrafish

PROJECT_TITLE: Elucidating Metabolic and Physicochemical Mechanisms of PAH Susceptibility in Toxicity Test Systems and Humans


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: GABAA receptors play a key role in mood, and drugs selective for recepor subclasses are in demand for treating neurospychiatric illness. Toward the goal of rationally leveraging selective treatments, we will elucidate the functions of two major types of GABAA receptors defined by a critical receptor subunit.

PI_NAMEs: MENNERICK, STEVEN J (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: antagonist;anti-depressive agents;Area;Behavior;Biological Markers;Biophysics;brain health;cell type;Cells;Clinical;Cognition;Cytoplasmic Granules;Data;defined contribution;delta receptors;dentate gyrus;Disinhibition;Dose;drug development;Drug Receptors;Drug Targeting;Endowment;Engineering;Epilepsy;Frequencies;gamma-Aminobutyric Acid;Genes;Genetic;Glutamate Receptor;Goals;Hippocampus;in vivo;in vivo evaluation;Individual;innovation;interest;Interneurons;kainate;Knock-in;Knock-out;Knowledge;Learning;Location;Mediating;mental function;Molecular;Mood Disorders;Moods;Mus;N-Methylaspartate;Neurons;neuropsychiatric disorder;neuropsychiatry;neurosteroids;Parvalbumins;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Physiological;Picrotoxin;Play;Point Mutation;Population;positive allosteric modulator;Property;receptor;receptor function;Receptor Inhibition;Receptor Signaling;Recombinants;Resistance;Role;Schizophrenia;side effect;Signal Transduction;Sleep;sleep spindle;Synapses;Technology;Testing;Thalamic structure;Therapeutic;Therapeutic Effect;tool

PROJECT_TITLE: GABAA RECEPTOR POPULATIONS IN HIPPOCAMPUS AND THALAMUS

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


NIH_SPENDING_CATS: Bioengineering;Endocrine Disruptors

PHR: PROJECT NARRATIVE – TANGUAY PROJECT Polycyclic aromatic hydrocarbons (PAHs) are some of the most common toxic chemicals found at the nation's Superfund sites. Our Center has begun to understand the overwhelming diversity of PAHs found at Superfund sites, and this project will systematically evaluate the toxicity of PAHs their mixtures. The goal is to help the research and regulatory communities predict the toxicity of real-world PAH mixtures.

PROJECT_TERMS: Address;Adult;Adverse effects;Age;Animals;Apical;Aromatic Polycyclic Hydrocarbons;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Behavioral;Benzo(a)pyrene;Biological;Biological Assay;Biosensor;Body mass index;Characteristics;Chemical Structure;Child;Collaborations;Communities;Complex;Complex Mixtures;Congenital Abnormality;Cytochrome P450;Data;Dependence;detection method;Development;Diagnostic;Diet;dietary;disease registry;Dose;dosimetry;Embryo;Environment;enzyme activity;epidemiologic data;Epigenetic Process;Evaluation;experimental study;exposed human population;Exposure to;Feedback;fitness;Gene Expression;Generations;Genetic Transcription;Goals;hazard;Hazard Assessment;Hazard Models;Hazardous Substances;Health;Heart Diseases;Human;in vivo;Indigenous;Individual;Knowledge;learned behavior;Learning;Life;Link;Measures;Metabolic;Metabolism;Methods;Modeling;Molecular;National Toxicology Program;neurobehavioral;new technology;offspring;Outcome;Parents;Pathway interactions;Pattern;Persons;Phenotype;phenotypic data;Poison;Population;predictive modeling;Public Health;Receptor Signaling;remediation;Research;response;Risk;Risk Assessment;Science;Scientist;Signal Recognition Particle;Social Behavior;Specificity;Structure;Superfund;superfund site;Testing;Tissues;tool;Toxic effect;Toxicology;Tribes;Uncertainty;uptake;user-friendly;Water;Work;Zebrafish

PROJECT_TITLE: Predicting the Toxicity of Complex PAH Mixtures


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Substance Misuse

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Alcohol use disorder is one of the most expensive and damaging of all chronic medical conditions and has few treatment options. Our work has shown that brain inflammatory signals promote excessive ethanol consumption and that pharmacological intervention with certain anti-inflammatory drugs reduces drinking. However, neuroinflammatory pathways are still an under-explored area in alcohol research, and our proposed experiments to explore the role of interferons have the potential to discover new approaches to reduce excessive drinking.

PI_NAMEs: BLEDNOV, YURI A (contact);MESSING, ROBERT O.

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Acute;Adaptor Signaling Protein;Agonist;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol research;alcohol response;alcohol sensitivity;alcohol use disorder;Alcohols;amlexanox;Animal Model;Anti-Inflammatory Agents;Area;Behavior;behavior test;behavioral response;behavioral study;Biochemical;Brain;brain cell;Brain imaging;Brain region;cell type;Chronic;chronic alcohol ingestion;Collaborations;connectome;CRISPR interference;Data;Data Set;Development;differential expression;Disease;drinking;Drug Targeting;Enterobacteria phage P1 Cre recombinase;Equilibrium;Ethanol;Etiology;experimental study;Gene Expression;Gene Modified;Genes;Genetic;Genetic Determinism;Genetic study;Genetic Transcription;Heavy Drinking;Human;hypnotic;imaging study;Inflammatory;inhibitor;innovation;Interferon Receptor;Interferon-beta;Interferons;Intervention;Investigation;kinase inhibitor;knock-down;Knock-out;Knockout Mice;Lipopolysaccharides;LoxP-flanked allele;Malignant Neoplasms;Mediating;Medical;Messenger RNA;Microinjections;multimodality;Mus;Myelogenous;Neuroglia;Neuroimmune;Neuroimmunomodulation;neuroinflammation;Neurons;new therapeutic target;novel strategies;null mutation;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Poly I-C;Prefrontal Cortex;problem drinker;Production;Proteins;Receptor Signaling;response;Response Elements;RNA;Role;Sampling;sedative;Signal Pathway;Signal Transduction;Signaling Molecule;Source;stem;TBK1 gene;Testing;Therapeutic Studies;TLR3 gene;TLR4 gene;TLR7 gene;Toll-like receptors;Transcript;transcription factor;transcriptome;transcriptomics;Translating;TYK2;vapor;Wild Type Mouse;Work

PROJECT_TITLE: 7/11 Biochemical and Genetic Determinants of Alcohol Consumption


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE Many people report using alcohol to alleviate stress. Yet heavy alcohol consumption provokes a stress response, resulting in a feed-forward cycle of stress-alcohol interactions that contribute to acquiring a diagnosis of alcohol use disorders. This project uses novel neuroscience technologies in rhesus monkeys to understand how the primate brain adapts to aberrant alcohol-stress interactions and open new pathways for developing personalized treatments for alcohol use disorders.

PI_NAMEs: GRANT, KATHLEEN A (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Abstinence;Address;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohols;allostasis;Amygdaloid structure;Area;Attention;Basal Ganglia;Behavior;Behavioral;biological adaptation to stress;Brain;Chronic;chronic alcohol ingestion;cohort;comorbidity;Consumption;Corpus striatum structure;Corticotropin;design;designer receptors exclusively activated by designer drugs;Development;Diagnosis;Dorsal;drinking;Equilibrium;Ethanol;executive function;flexibility;Functional Magnetic Resonance Imaging;Glutamates;Heavy Drinking;Histology;Homeostasis;Hydrocortisone;Hypothalamic structure;Individual Differences;individual response;innovation;Insula of Reil;interest;Intoxication;Lateral;locus ceruleus structure;Macaca mulatta;Measures;Medial;Mediating;Modeling;Molecular Analysis;Monkeys;Motor;multimodality;neural circuit;neuroadaptation;Neurons;Neurosciences;novel;Outcome;Output;Pathway interactions;Performance;personalized medicine;Persons;Phenotype;Pituitary Gland;Play;Predisposition;Prefrontal Cortex;Primates;Procedures;Protocols documentation;putamen;Regulation;Relapse;Reporting;Research;Rest;Rodent;Role;Self Administration;Sensory;sex;Sex Differences;Slice;Spectrum Analysis;Stress;Task Performances;Technology;Testing;Thalamic structure;Tissues;transmission process;Ventral Striatum;Water

PROJECT_TITLE: 6/8: INIA Stress and Chronic Alcohol Interactions: Stress and Ethanol Self Administration in Monkeys


NIH_SPENDING_CATS: Bioengineering;Clinical Research

PHR: PROJECT NARRATIVE – ANDERSON PROJECT We propose to develop and test generalizable technology to measure movement of bioavailable PAHs between sediment, water, and air at Superfund sites relative to seasonal and tidal variations. We will determine where and how much PAHs are moving at Superfund sites, providing regulators and stakeholders key information to assess potential remediation strategies, assess remediation performance and understand key system parameters of as a function of daily and seasonal time scales. With novel chemical exposure wristband sampler technology, we will describe to stakeholders and communities a) how external exposure to PAH mixtures varies as a function of location near a Superfund site, b) which components of the mixtures, if any, may threaten human health, and c) how remediation of a Superfund site influences the local community's external exposure to PAHs.

PROJECT_TERMS: Address;Air;Aromatic Polycyclic Hydrocarbons;Atmosphere;Behavior;Biological;Biological Availability;Cell Culture Techniques;Characteristics;Chemical Exposure;Chemicals;Collaborations;Communities;cost effective;Creosote;daily functioning;Data;Dependence;Devices;effectiveness evaluation;Environment;Exposure to;Geographic Factor;Hazardous Substances;Health;Hour;Housing;Human;Individual;Location;Lung;Measurement;Measures;meter;Methods;Modeling;Movement;new technology;novel;Pattern;Performance;Persons;Poison;remediation;Risk;Risk Assessment;Sampling;Seasonal Variations;Seasons;Signal Recognition Particle;Site;sound;Superfund;superfund site;System;Technology;Testing;Time;tool;Toxic effect;Toxicity Tests;Translational Research;Variant;Water;wristband;Zebrafish

PROJECT_TITLE: Developing and Evaluating Technology to Measure PAH Fate and Exposures


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurofibromatosis;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: The goal of the current proposal is to bring new insight into the fundamental mechanisms of Neurofibromatosis type 1 (NF1) - associated mutations on the cellular behaviors of human specific progenitor subtypes during early cortical development and on neuronal network activity. Thus, the proposed research has the potential to advance our understanding of the neuropathophysiology of NF1 and to fertilize the development of novel therapeutics strategies for NF1, which is relevant to the mission of NINDS that pertains to seeking fundamental knowledge about the brain and nervous system that will help to reduce the burden of neurological disease.

PI_NAMEs: YANG, NAN  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Affect;Alleles;Animal Model;Architecture;autism spectrum disorder;Behavioral;Biological Assay;Biological Models;Biological Process;Brain;Brain Diseases;brain dysfunction;cell behavior;Cell Differentiation process;Cell division;Cell Line;Cell model;Cell Physiology;Cell Proliferation;cell type;Cells;Clinic;Clinical;Clinical Trials;Cognitive deficits;Complex;Cytokinesis;Data;Defect;Deformity;Development;Disease;disease model;disorder prevention;Electrodes;Electrophysiology (science);Epigenetic Process;Evolution;excitatory neuron;First Pregnancy Trimester;Fostering;Functional disorder;gamma-Aminobutyric Acid;Gene Expression Profiling;gene regulatory network;Genetic Engineering;Goals;Heterozygote;High Prevalence;Human;human induced pluripotent stem cells;human model;Imaging Device;Impaired cognition;Impairment;improved;Individual;Induced Neurons;induced pluripotent stem cell;inhibitory neuron;insight;interdisciplinary approach;Investigation;Knowledge;Laboratories;Lead;loss of function mutation;Macrocephaly;Measurement;migration;Mission;Mitotic;Modeling;Molecular;Morphology;mouse model;Mus;mutant;Mutation;National Institute of Neurological Disorders and Stroke;nerve stem cell;Nervous System;Nervous System Disorder;neural;Neurobehavioral Manifestations;neurodevelopment;Neurodevelopmental Disorder;Neuroepithelial;Neuroepithelial Cells;Neurofibromatosis 1;Neuroglia;Neurologic;Neuronal Differentiation;Neurons;NF1 gene;novel;novel therapeutic intervention;novel therapeutics;Organoids;Output;Pathogenesis;Pathogenicity;Patients;Phenotype;Pilot Projects;progenitor;Proliferating;Property;Proteins;Publishing;Radial;Research;Rodent;Role;Screening procedure;Signal Pathway;species difference;stem cell biology;stem cells;Synapses;Synaptic Transmission;System;Testing;Therapeutic;tool;transcriptome;Transgenic Organisms;Translations;treatment strategy;Ventricular;Work

PROJECT_TITLE: Cellular and Molecular Mechanisms of Brain Dysfunction in NF1


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Infertility;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Precision Medicine;Pregnancy;Prevention;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative In this application we plan to finalize and externally validate two potential diagnostic aids based on novel biomarkers to identify (1) location and (2) viability of an early gestation. With the inclusion of novel biomarkers we plan to refine a serum multiple marker test and validate its performance in a population based prospective cohort. We also plan to explore it use in combination with a patient sign and symptoms at presentation for care and it use in other populations.

PI_NAMEs: BARNHART, KURT T (contact)

PROGRAM_OFFICER_NAME: SEN, ARITRO

PROJECT_TERMS: Affect;Area;Biological;Biological Markers;biomarker development;biomarker panel;biomarker performance;Caring;Cause of Death;Cessation of life;Characteristics;classification algorithm;Clinical;clinical care;Clinical Management;Clinical Trials;companion diagnostics;Complement;Consumption;Data;design;Development Plans;Diagnosis;Diagnostic;diagnostic tool;Discipline of obstetrics;Discrimination;Disease;early pregnancy;early pregnancy loss;Ectopic Pregnancy;Ethnic Origin;feature selection;First Pregnancy Trimester;Funding;Gestational Age;Goals;Gynecologic;health care delivery;Hemorrhage;High Risk Woman;Human Chorionic Gonadotropin;Iatrogenesis;improved;interest;Interruption;Location;Machine Learning;machine learning algorithm;Mammalian Oviducts;Medical;Medical Care Team;Methodology;model building;Modeling;Morbidity - disease rate;National Institute of Child Health and Human Development;novel;novel marker;Pain;pain symptom;Pathway interactions;Patients;Performance;Physiology;Population;population based;predictive marker;Predictive Value;Predictive Value of Tests;Pregnancy;pregnancy failure;Pregnancy Outcome;Procedures;Process;Productivity;Prospective cohort;Prospective Studies;Proteomics;Race;random forest;Recording of previous events;regression trees;Research;Research Priority;Resources;Risk;Rupture;Sampling;screening;Serum;Signs and Symptoms;Spontaneous abortion;Stress;Subgroup;Symptoms;System;Testing;Time;ultrasound;Uncertainty;United States National Institutes of Health;Uterus;Validation;Woman;women's diagnosis;Women's mortality;Work

PROJECT_TITLE: Clinical utility of novel biomarkers for prediction of early pregnancy failure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(90)S]


PHR: PROJECT NARRATIVE – SIMONICH/SEMPRINI PROJECT This project will enhance health, lengthen life, and reduce illness and disability by identifying and recommending remediation technologies that reduce human exposure to hazardous pollutants and minimize the formation of hazardous breakdown products.

PI_NAMEs: SEMPRINI, LEWIS  (contact)

PROJECT_TERMS: Address;Attenuated;attenuation;Back;Biological;Biological Availability;Chemicals;Computer Models;Data;Detection;Devices;disability;Environment;Epoxy Compounds;experimental study;exposed human population;Exposure to;Funding;Goals;ground water;Hazardous Substances;Health;Human;In Situ;Laboratories;Learning;Life;Measures;Methods;microbial;National Institute of Environmental Health Sciences;new technology;oxidation;Parents;pollutant;programs;Property;Recommendation;remediation;Research;Research Project Grants;Risk;Sampling;Signal Recognition Particle;Site;Societies;Soil;Structure;Superfund;superfund site;Techniques;Technology;Testing;Toxic effect

PROJECT_TITLE: Identification of Remediation Technologies and Conditions that Minimize Formation of Hazardous PAH Breakdown Products at Superfund Sites


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Diabetes;Hypertension;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative/Public Health Relevance The goals of this proposed study are to examine the trends in the prevalence and incidence of Alzheimer’s disease related dementias (ADRDs) over the past 30 years (1991-2020) and to determine whether, and to what extent, the risk of ADRD is affected by anticancer, antihypertensive and antidiabetic drug therapies. There is no large cohort study monitoring and assessing the effects of these medications on the risk of developing ADRDs. This study takes advantage of the unique opportunity provided by Medicare Part-D comprehensive drug coverage, which was implemented in 2006, wherein medication use for millions of recipients is documented, thereby making it possible to determine the impact of the use of these medications on the risk of developing these dementias.

PI_NAMEs: DU, XIANGLIN  (contact)

PROGRAM_OFFICER_NAME: FENG, LI REBEKAH

PROJECT_TERMS: Accounting;Address;Adult;Affect;Age;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;anti-cancer;Anti-diabetic Drugs;Anti-Hypertensive Agents;Antineoplastic Agents;Area;Attention;beneficiary;blood pressure control;blood pressure intervention;Breast;cancer diagnosis;Cancer Patient;cancer therapy;Cause of Death;chemotherapy;Chemotherapy-Oncologic Procedure;Child;Clinical Trials;Cognition;Cognitive;cohort;Cohort Studies;Colorectal;comorbidity;Confidence Intervals;Cranial Irradiation;Craniocerebral Trauma;Data;Databases;Dementia;dementia risk;design;Diabetes Mellitus;diabetes mellitus therapy;Diagnosis;Disease;Education;effective therapy;Electronics;Ethnic Origin;follow-up;Gender;Geographic Locations;Goals;hazard;High Prevalence;human old age (65+);Hypertension;Impaired cognition;Incidence;Intervention Trial;Joints;Language;Late Effects;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Medical Records;Medicare;Medicare claim;Memory;Mental disorders;mild cognitive impairment;Monitor;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Population;Prevalence;prevent;Prevention strategy;Prostate;public health relevance;Race;randomized trial;Recording of previous events;Reporting;Research;Research Personnel;Resources;Risk;Risk Factors;Sampling;SEER Program;skills;small cell lung carcinoma;social;Testing;Time;trend;United States;Variant;Vascular Diseases;vascular factor

PROJECT_TITLE: The Risk of Developing Alzheimer’s Disease and Related Dementias Associated with Hypertension, Diabetes, and Drug Therapies for Cancer: Up to 30-year Follow-up for Older Medicare Beneficiaries

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(55)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LOUISVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Decades of research have demonstrated that the immune system can eradicate cancer cells but only if immune evasion mechanisms, such as immune checkpoint proteins, can be overcome. Multiple new immunotherapeutic approaches have recently been developed that can induce durable remissions in patients with advanced cancers – unfortunately, the majority of patients still succumb to their cancers. The goal of this COBRE application is to establish a new Center for Cancer Immunology and Immunotherapy that will focus on understanding immune escape mechanisms, developing new approaches to activate/reinvigorate anticancer immunity, training promising young cancer immunologists and improving the research infrastructure of the University of Louisville.

PI_NAMEs: CHESNEY, JASON A.;YAN, JUN  (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Adoptive Cell Transfers;Advanced Malignant Neoplasm;Advisory Committees;Animals;anti-cancer;Antibodies;Area;Award;Basic Science;Bioinformatics;Biological Markers;Biomedical Research;Biometry;Bladder;cancer cell;Cancer Center;cancer clinical trial;Cancer Death Rates;cancer immunotherapy;cancer therapy;cancer type;CAR T cell therapy;career development;Centers of Research Excellence;checkpoint therapy;chimeric antigen receptor T cells;Clinical;Clinical Trials;cohort;Collaborations;Conduct Clinical Trials;Country;CTLA4 gene;Cytometry;Development;Diagnosis;Discipline;Disease remission;Disseminated Malignant Neoplasm;Early Diagnosis;equipment acquisition;Financial Support;Flow Cytometry;Funding;Future;Genomics;Goals;Grant;Growth;Head and neck structure;Home;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immune system;Immunologic Surveillance;Immunologist;Immunotherapeutic agent;Immunotherapy;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;International;Investments;Kidney;Lung;Malignant Neoplasms;Mediating;Melanoma;member;Mentors;microbiome research;Mission;Molecular;Mus;Names;new therapeutic target;novel strategies;novel therapeutic intervention;Oncolytic viruses;optimism;Outcome;Paper;Patients;Personnel Selection;Persons;Phase;Pilot Projects;programmed cell death ligand 1;programmed cell death protein 1;programs;Proteins;Publications;Qualifying;Recording of previous events;recruit;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resistance;Resources;response;Sampling;Seminal;senior faculty;Services;side effect;Specimen;statistics;Study Section;success;systemic toxicity;T cell therapy;Talents;Testing;Training;Translating;Translational Research;treatment strategy;tumor;Tumor Immunity;tumor immunology;Universities;Vaccines;Work

PROJECT_TITLE: Center for Cancer Immunology and Immunotherapy (CCII)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Immunotherapy

PI_NAMEs: YAN, JUN  (contact)

PROJECT_TERMS: Acceleration;Adoptive Cell Transfers;Advisory Committees;Applications Grants;Area;Award;Bacterial Infections;Basic Science;Bioinformatics;Biometry;Cancer Biology;Cancer Center;cancer immunotherapeutics;cancer immunotherapy;Cancer Patient;career;Centers of Research Excellence;Clinical;Clinical Research;Collaborations;Coupled;Credentialing;Decision Making;diversity and inclusion;Education;Ensure;Evaluation;experience;Feasibility Studies;Feedback;Feeling hopeless;Funding;Goals;Grant;Human;Human Resources;Immune checkpoint inhibitor;Immune mediated destruction;Immune response;Immune system;Immunology;Immunotherapeutic agent;improved;Individual;innovation;Interdisciplinary Study;interest;International;Leadership;Malignant Neoplasms;meetings;member;Mentors;Mentorship;Molecular;Molecular Profiling;multidisciplinary;neoplastic cell;next generation;Nobel Prize;novel;Oncolytic viruses;operation;Participant;Patients;Physicians;Pilot Projects;Prediction of Response to Therapy;Procedures;Productivity;programs;Qualifying;Research;Research Personnel;Resistance;response;Role;Scientist;senior faculty;Specimen;Strategic Planning;Study Section;success;Testing;Training Programs;Translational Research;translational study;Treatment outcome;tumor;Tumor Escape;tumor immunology;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Pediatric

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE  We will investigate new classes of molecules as targets of the immune response in type 1 diabetes, which is a growing health problem that is associated with significant morbidity and mortality. Our project will identify therapeutic and immune monitoring targets and lay a foundation for the development of an antigen- specific therapy for type 1 diabetes.

PI_NAMEs: DILORENZO, TERESA P (contact);PURCELL, ANTHONY

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Address;Alleles;Amino Acids;Antigens;Autoantigens;autoreactive T cell;Beta Cell;Binding;Bioinformatics;Cancer Patient;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell killing;Cell Separation;Cells;central tolerance;Clone Cells;Code;Collection;Coupled;Cytotoxic T-Lymphocytes;Darkness;Detection;Development;Digestion;Disease;Epitopes;Foundations;Future;Generations;Health;Histocompatibility Antigens Class I;HLA-A gene;HLA-B Antigens;Human;human subject;Human Subject Research;Hybrids;Immune response;Immune Targeting;Immunologic Monitoring;In Vitro;Inbred NOD Mice;Individual;Infiltration;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;Insulinase;interest;islet;Islet Cell;Islets of Langerhans;Knowledge;Ligands;Link;Mass Spectrum Analysis;Messenger RNA;Methods;MHC binding peptide;MHC Class I Genes;Modeling;Morbidity - disease rate;mortality;mouse model;multicatalytic endopeptidase complex;Nature;Open Reading Frames;Pathogenesis;Pathogenicity;Patients;Peptides;Peripheral Blood Mononuclear Cell;Positioning Attribute;Proinsulin;Protein Databases;Proteins;Protocols documentation;Recommendation;Reporting;Research Project Grants;Resources;RNA Splicing;Sampling;Secretory Vesicles;Source;Specimen;Structure;T cell response;T-Cell Immunologic Specificity;T-Lymphocyte;T-Lymphocyte Epitopes;T-Lymphocyte Subsets;Testing;Text;Therapeutic;Thymus Gland;tumor;Work

PROJECT_TITLE: The "dark immunopeptidome" as a source of CD8 T cell epitopes in type 1 diabetes


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Mammographic density is one of the strongest known risk factors for breast cancer, but previous studies have almost exclusively been limited to non-Hispanic White women. The proposed research sets out to study non- genetic and genetic risk factors of high mammographic density in a large, diverse population of Hispanic women. Completion of the study aims will advance our understanding of mammographic density and provide insights into racial disparities in breast cancer.

PI_NAMEs: LINDSTROEM, SARA  (contact)

PROGRAM_OFFICER_NAME: NELSON, STEFANIE A

PROJECT_TERMS: Adipose tissue;anti-cancer research;Area;Asian Women;Biological;Black race;Breast;Breast Cancer Detection;Breast Cancer Risk Factor;breast density;cancer subtypes;Caring;Cause of Death;Central American;Clinical;cohort;Collection;Cuban;Data;density;Disease;Dominican;Enrollment;epidemiology study;Epithelium;Ethnic Population;evidence base;Fatty acid glycerol esters;Future;Genetic;genetic association;genetic risk factor;genome wide association study;Health;Health Personnel;high body mass index;Hispanic;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Hispanic Women;Individual;insight;Joints;Knowledge;Latina;Latina Population;Learning;Life Style;lifestyle factors;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic Density;Mammography;Measures;Menopausal Status;Mexican;non-genetic;Not Hispanic or Latino;novel;Obesity;Outcome;Participant;Pathway interactions;Pattern;Phenotype;Population;Population Heterogeneity;Postmenopause;Premenopause;Puerto Rican;racial disparity;racial population;repository;reproductive;Reproductive History;Research;Resources;Risk Factors;Sample Size;Sampling;Site;social culture;South American;Surrogate Markers;Time;Tissues;White Women;Woman

PROJECT_TITLE: The impact of lifestyle and genetic factors on mammographic density in a cohort of Hispanic women

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


PI_NAMEs: LI, BING  (contact)

PROJECT_TERMS: Applications Grants;Area;Biological Specimen Banks;Blood;Cancer Center;cancer immunotherapy;Cancer Patient;Cell Separation;Cells;Centers of Research Excellence;Clinic;Clinical;clinical application;Contract Services;Core Facility;Cytometry;Data;Databases;Decentralization;Dedications;design;Development;DNA;Education;Ensure;equipment acquisition;Extramural Activities;Fee-for-Service Plans;Flow Cytometry;Freezing;Funding;Future;Genomics;Goals;Human;Human Resources;Immune;Immune system;Immunofluorescence Immunologic;Immunologic Monitoring;Immunologics;Immunooncology;Immunotherapy;Infrastructure;innovation;Institution;instrument;instrumentation;interest;Investments;Kentucky;Location;Malignant Neoplasms;member;Molecular;Mus;new therapeutic target;novel;operation;Paraffin Embedding;Patients;Phase;Phenotype;Process;prospective;Proteins;Protocols documentation;Publications;Qualifying;Research;Research Personnel;Research Support;Resources;RNA;Running;Sampling;Services;Site;Slide;Specimen;Stains;success;Technology;tissue processing;tissue/cell preparation;Tissues;Training;Training and Education;transcriptomics;Translations;treatment strategy;tumor;tumor immunology;Tumor-Associated Process;Universities;University resources;Writing

PROJECT_TITLE: Functional Immunomics Core


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Immunotherapy;Women's Health Research

PI_NAMEs: DING, CHUANLIN  (contact)

PROJECT_TERMS: Address;anti-tumor immune response;Antioxidants;antitumor effect;Bone Marrow;Breast Cancer cell line;Breast Cancer Patient;Cancer Center;cancer immunotherapy;cancer therapy;Cells;Centers of Research Excellence;chemokine;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;Clinical Management;Combination Drug Therapy;combinatorial;CX3CL1 gene;cytokine;Data;Dose;Fluorouracil;gemcitabine;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;Hematopoiesis;Hematopoietic stem cells;Human;Immune response;Immune system;Immunity;Immunocompetence;Immunosuppression;In Vitro;in vivo;Inflammation;Inflammatory;Intercellular adhesion molecule 1;Investigation;Mitochondria;monocyte;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Oxidative Phosphorylation;Paclitaxel;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;Production;programs;rational design;Reactive Oxygen Species;receptor;Recruitment Activity;Regimen;response;Role;Side;Stromal Cells;Testing;Tissues;Treatment Efficacy;tumor;tumor eradication;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Tumor-associated macrophages;Tumor-Derived;Up-Regulation

PROJECT_TITLE: Ongoing inflammation following chemotherapy induces immunosuppression


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Immunotherapy;Lung;Lung Cancer;Microbiome

PI_NAMEs: LI, QINGSHENG  (contact)

PROJECT_TERMS: Address;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;Bioinformatics;Biopsy Specimen;Cancer Center;cancer immunotherapy;Cancer Model;Cancer Patient;CD3 Antigens;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;checkpoint therapy;Clinic;Clinical;clinically relevant;commensal bacteria;cytotoxic;cytotoxicity;Data;design;Disease;Failure;FDA approved;Generations;Germ-Free;Goals;Grant;Growth;Human;human microbiota;IL17 gene;Immune checkpoint inhibitor;Immunity;Immunotherapy;in vivo;Individual;interstitial;KRASG12D;Lung;Lung Adenocarcinoma;lung microbiota;Lung Neoplasms;Lymphocyte;Lymphocyte Activation;Macrophage;Macrophage Activation;Malignant neoplasm of lung;Mediating;microbiota;microbiota profiles;mouse model;Mus;Neoadjuvant Therapy;neoantigens;neoplastic;neutralizing antibody;Non-Small-Cell Lung Carcinoma;novel;Operative Surgical Procedures;Patients;predicting response;Production;prognostic;prognostication;programmed cell death protein 1;Progression-Free Survivals;prospective;Psoriasis;Resistance;resistance factors;resistance mechanism;response;restoration;Severities;Specimen;standard of care;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapy outcome;tumor;tumor immunology;tumorigenic;γδ T cells

PROJECT_TITLE: Mechanisms of resistance to immune therapy in NSCLC


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: The brain is very vulnerable to metabolic problems and synapses, the machinery that mediates the conversion of electrical information into chemical information, are very sensitive to metabolic imbalances. Since neurodegenerative diseases results in improper function of synapses, we hypothesize that these disease states have a strong metabolic component arising from an imbalance in fuel availability and fuel use at the level of individual synapses. The fuel here that matters is a molecule called ATP and our work aims to understand how it is produced at synapses, who consumes it and how in diseases that cause dementia (e.g. Alzheimer’s) this changes.

PI_NAMEs: RYAN, TIMOTHY AIDAN (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Action Potentials;Adenosine Triphosphate;Age;age related;age related decline;age related neurodegeneration;Aging;aging population;Alzheimer's Disease;Auxilins;Biochemical;Blood Glucose;Blood Vessels;Brain;Chemicals;Clinical;Coma;comparison control;Consumption;Data;Delirium;Dementia;Disease;Disease Progression;DNA Sequence Alteration;Dopamine;dopamine transporter;dopaminergic neuron;Drops;Economic Burden;Elements;Endocytosis;Equilibrium;Functional disorder;Genes;Genetic;Glucose;Glycolysis;Heritability;Hippocampus;Human;Hypoglycemia;Impairment;Individual;insight;Intervention;Knowledge;Laboratories;Lead;Learning;LRRK2 gene;Mediating;Medical;Metabolic;Metabolic Control;Metabolism;Mitochondria;Molecular;Movement Disorders;Mutate;Mutation;Nerve;Neurodegenerative Disorders;Neurologic;Neurologic Deficit;Neurologic Symptoms;Neurologist;neuron loss;Neurons;Neurotransmitters;novel therapeutics;Organ;Oxidative Phosphorylation;PARK2 gene;PARK7 gene;PARK8 gene;Parkin;Parkinson Disease;pars compacta;Pathology;Patients;Performance;Phenotype;Population;presynaptic;Production;Protons;Pyruvate;Recycling;response;Rest;Risk;Running;Series;Societies;socioeconomics;Structural defect;Substantia nigra structure;Symptoms;Synapses;synaptic function;Synaptic Vesicles;SYNJ1 gene;Testing;Time;Tissues;Up-Regulation;uptake;usability;vacuolar H+-ATPase;Vesicle;Work

PROJECT_TITLE: Metabolic Vulnerability of Synapses in Neurodegenerative Disease

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Immunotherapy;Lung;Lung Cancer

PI_NAMEs: YADDANAPUDI, KAVITHA  (contact)

PROJECT_TERMS: 5'-Nucleotidase;Adenosine;adenosine deaminase;Adopted;Advanced Malignant Neoplasm;anti-CTLA4 antibodies;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;Attenuated;Cancer Center;cancer immunotherapy;Cancer Model;Cancer Patient;Cattle;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cell surface;Cells;Child;Clinical;clinically relevant;conditional knockout;Consumption;CREB1 gene;Critical Pathways;Cyclic AMP;Data;Dinoprostone;Disease;effector T cell;enzyme replacement therapy;Enzymes;extracellular;FDA approved;Frequencies;Generations;Goals;Homing;Human;Immune;Immune Cell Suppression;Immune checkpoint inhibitor;Immune system;Immunotherapeutic agent;Immunotherapy;Impairment;Implant;improved;In complete remission;In Vitro;in vivo;Infiltration;inhibitor;inhibitor therapy;Inosine;insight;Knock-out;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mediator;Molecular;monocyte;mouse model;Mus;Myeloid-derived suppressor cells;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;Nucleosides;objective response rate;Outcome;Pathway interactions;Patients;PD-1 inhibitors;pembrolizumab;Polyethylene Glycols;Production;programmed cell death ligand 1;Prostaglandin Inhibition;Purine Nucleosides;Regulation;Resistance;response;Severe Combined Immunodeficiency;Signal Pathway;Signal Transduction;STAT3 gene;T-Cell Activation;T-Lymphocyte;Testing;therapeutic target;therapy development;therapy resistant;transcription factor;Transgenic Model;tumor;tumor growth;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor Promotion;Tumor-Derived

PROJECT_TITLE: Overcoming resistance to cancer immunotherapy by targeting MDSC-derived adenosine


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

PI_NAMEs: CHEN, JOSEPH  (contact);CHESNEY, JASON A.

PROJECT_TERMS: Address;Biophysics;Cancer Center;cancer immunotherapy;CD44 gene;Cell surface;Extracellular Matrix;Genetic Transcription;Glioblastoma;Hyaluronic Acid;IL17 gene;Immune;Immunosuppression;Infiltration;Interleukin-6;Mediating;Mesenchymal;monocyte;Myeloid-derived suppressor cells;novel;Pathway interactions;programs;recruit;Role;STAT3 gene;tumor;tumor immunology

PROJECT_TITLE: The role of ECM-mediated mechanosignaling on regional immunosuppression in GBM


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Childhood Injury;Clinical Research;Genetics;Infectious Diseases;Lung;Microbiome;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Each year in the United States, over 2,500 children undergo hematopoietic cell transplantation (HCT) as life- saving therapy for cancers, immunodeficiencies, blood disorders, and many other life-threatening diseases. After HCT, many children develop complex lung disease triggered by infections, chemotherapy, the transplanted immune system, and other factors. An improved understanding of the pathobiologic role of pulmonary infections and pulmonary inflammation is necessary in order to improve survival after pediatric HCT and thus constitutes the focus of this proposal.

PI_NAMEs: ZINTER, MATTHEW SCOTT (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Academic Medical Centers;accurate diagnosis;Admission activity;Australia;biobank;Bioinformatics;Biological;Biological Assay;Biology;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;California;Canada;cancer therapy;career;career development;Characteristics;chemotherapy;Child;Childhood;Childhood Injury;Classification;Clinical;clinical diagnostics;clinical practice;Clinical Sciences;Coagulation Process;cohort;Complex;Computational Science;Critical Care;Data;Data Set;Death Rate;Dedications;Detection;Development;Development Plans;Diagnostic;Diagnostic tests;Disease;disease phenotype;dysbiosis;Endothelium;epithelial injury;experience;Faculty;Failure;Fibrinolysis;Fluid overload;Future;Gene Expression;Gene Expression Profile;Geography;Goals;graft vs host disease;Hematological Disease;Hematopoietic Stem Cell Transplantation;high risk;Human;Immune;immunodeficiency;improved;improved outcome;Infection;Inflammation;Injury;Interstitial Pneumonia;Intervention;Investigation;Investigational Therapies;Knowledge;Life;Lung;Lung Diseases;Lung infections;lung injury;lung microbiome;lung pathogen;Lung Transplantation;Malignant - descriptor;Measures;Mediating;Medicine;Mentors;metagenomic sequencing;Metagenomics;Methodology;Microbe;microbial;microbial composition;microbiome;microbiome research;microbiome signature;Modeling;Molecular;Molecular Target;molecular targeted therapies;mortality;Netherlands;next generation sequencing;Non-Malignant;Organism;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Pediatric cohort;Pediatric Hospitals;Pediatric Intensive Care Units;Phenotype;Physicians;Population;Positioning Attribute;prognostic;Pulmonary Inflammation;Research;respiratory;Respiratory Tract Infections;RNA;Role;San Francisco;Scientist;targeted treatment;Technology;Testing;Toxic effect;Training;trait;Transcript;translational potential;Translational Research;transplant model;Transplant Recipients;Transplantation;Transplantation and Immune System;Treatment-related toxicity;United States;Universities;Viral;Work

PROJECT_TITLE: Pathobiologic Transcriptional Signatures of Pulmonary Complications in Pediatric Hematopoietic Cellular Transplantation

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE Sepsis or blood poisoning is a life-threatening illness arising when the body is overcome by infection that has spread through the bloodstream. Sepsis is a major cause of death worldwide. Currently, there are no effective treatments that can cure sepsis. This project aims to understand how the host responds to blood infections, and to develop new therapies that could protect the organs against the damaging effects of the body's own uncontrolled defense systems.

PI_NAMEs: LUPU, FLOREA  (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: activation product;Affect;Amplifiers;Anaphylatoxins;Animal Model;Animals;antagonist;Antibiotics;Anticoagulants;Anticoagulation;Antimicrobial Effect;Aspartate Transaminase;Attenuated;Bacillus;Bacillus anthracis;Bacteremia;Bacteria;Basic Science;Biological Markers;Blood Circulation;Blood Coagulation Disorders;Blood Urea Nitrogen;C5a anaphylatoxin receptor;Cause of Death;Cell Death;Cessation of life;clinically relevant;Coagulation Process;Combined Modality Therapy;Complement;Complement 3 Convertase;Complement 3b;Complement 5a;Complement Activation;Complement component C5;Complement Membrane Attack Complex;complement pathway;Complex;Contact Inhibition;Creatinine;Data;Development;Disease;Disease Progression;Early treatment;effective therapy;Escherichia;Escherichia coli;Functional disorder;Genus staphylococcus;Goals;Gram-Negative Bacteria;Hemolysis;Host Defense;Hour;hypoperfusion;Immune response;Immune Tolerance;Impairment;improved;improved outcome;Individual;Infection;Inflammation;Inflammatory Response;inhibiting antibody;inhibitor;innovation;Intensive Care Units;Kidney Failure;Lead;Lethal Dose 50;Life;Lipopolysaccharides;Mediating;Mediator;microbial;Modeling;Multiple Organ Failure;Myocardial dysfunction;nonhuman primate;novel;novel therapeutics;Organ;Organ failure;Papio;pathogen;Pathogenesis;Pathway interactions;Patients;Peptidoglycan;Phagocytosis;Plasma;Play;pre-clinical research;preservation;prevent;Prothrombin time assay;receptor;Recovery;Reperfusion Injury;response;Role;Sepsis;septic;septic patients;Septicemia;Shock;Signal Transduction;Staphylococcus aureus;Syndrome;System;systemic inflammatory response;targeted treatment;Testing;Therapeutic;Thrombosis;Time;Tissues;Vascular Diseases

PROJECT_TITLE: Complement C5 inhibition as sepsis therapy

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Substance Misuse

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative There is a significant underrepresentation of Hispanic/Latinx investigators in the research workforce with Hispanics contributing with a 6% of all funded NIH grants, even though Hispanics represent 18% of the total US population. The goal of this application is to create a highly focused, intense, and personalized mentoring program to train 12 junior Hispanic/Latinx students, post-docs and recently hired faculty members. Mentoring and training activities will be conducted during an expanded and enhanced version of the annual meeting of the American Society of Hispanic Psychiatry by a group of mid-career and senior Hispanic/Latinx investigators with a track record in NIH funding.

PI_NAMEs: GALLEGO, JUAN ANDRES (contact)

PROGRAM_OFFICER_NAME: MEZA-CERVERA, TATIANA

PROJECT_TERMS: Academic support;Address;Agreement;American;American Psychiatric Association;Area;Award;Books;career;Data;Educational workshop;Ethnic Origin;experience;Faculty;Feedback;Financial Support;follow-up;Fostering;Funding;Goals;Grant;Growth;Hispanic;Hispanic Populations;Hour;improved;interest;Latino;Latinx;lectures;meetings;member;Mental Health;Mentors;Mentorship;Minority;minority health;minority health disparity;National Institute of Drug Abuse;National Institute of Mental Health;Not Hispanic or Latino;Outcome;Paper;Peer Review;Physicians;Population;Postdoctoral Fellow;posters;programs;Psychiatrist;Psychiatry;Psychologist;Psychology;Publications;Publishing;Race;Research;Research Personnel;role model;Scientist;Series;Social Work;Social Workers;Societies;Solid;Strategic Planning;Students;symposium;synergism;Training;Training Activity;Training Support;United States National Institutes of Health;Vertebral column;virtual;Work;Writing

PROJECT_TITLE: Critical Research Issues in Latinx Mental Health/American Society of Hispanic Psychiatry


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative The overall goal of this proposal is to improve the outcome of heart transplantation by developing a method of targeted delivery for immune therapeutics that will increase their efficacy and reduce their toxicity.

PI_NAMEs: ABDI, REZA  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Acute;Adopted;Alloantigen;allograft rejection;Allografting;Antibody-drug conjugates;Biological Assay;Chronic;clinical application;collaborative approach;Data;dosage;draining lymph node;Drug Delivery Systems;Drug Targeting;experimental study;Generations;Goals;heart allograft;Heart Diseases;Heart Transplantation;imaging study;Immune;Immune Targeting;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;Infection;innovation;interest;Kinetics;Life;Malignant Neoplasms;Metabolic syndrome;Methods;Modeling;mouse model;multidisciplinary;Mus;nanoparticle;Nanotechnology;novel;Organ;Patients;Phenotype;post-transplant;prevent;programs;Research;T-Lymphocyte;targeted delivery;targeted treatment;Techniques;Therapeutic;Therapeutic immunosuppression;Therapeutic Uses;Time;Tissues;Toxic effect;trafficking;transplant model;Transplant Recipients;Transplantation

PROJECT_TITLE: Targeted immune therapies in heart transplantation


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

ORG_CITY: POMONA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WESTERN UNIVERSITY OF HEALTH SCIENCES

PHR: Project Narrative Appropriate modulation of insulin clearance (the removal of insulin from the circulation) is critical for the prevention of diabetes in at-risk individuals. This objective of this study is to identify genes that affect risk for type 2 diabetes through the regulation of insulin clearance. Cellular and animal studies will be conducted to define the function of these genes yielding knowledge that may lead to improvements in prevention and treatment of diabetes.

PI_NAMEs: NAJJAR, SONIA M.;PETERFY, MIKLOS  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Ablation;Adipose tissue;Affect;Animals;Anti-diabetic Drugs;Area;Attention;Automobile Driving;Beta Cell;Binding;Blindness;blood glucose regulation;C-Peptide;cardiovascular disorder risk;CEACAM1;cell growth regulation;Cell Line;Cells;Circulation;Collection;Compensatory Hyperinsulinemia;db/db mouse;Defect;Dependovirus;Development;Diabetes Mellitus;Diabetes prevention;diabetes risk;diet-induced obesity;Down-Regulation;Endosomes;Epidemic;Etiology;Excision;follow-up;Foundations;Functional disorder;gain of function;gene function;Genes;Genetic;genetic approach;Genetic Determinism;genome wide association study;Hepatic;Hepatocyte;hepatoma cell;Heritability;Homeostasis;Human;Hybrids;Hyperinsulinism;Impairment;improved;Inbred Strains Mice;Individual;insight;Insulin;Insulin Receptor;insulin regulation;Insulin Resistance;insulin secretion;Investigation;Kidney Failure;Knowledge;limb amputation;Liver;longitudinal analysis;loss of function;Measures;Mediating;Mediator;Metabolic;Metabolism;Molecular;Mus;Muscle;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obese Mice;Obesity;overexpression;pancreatic juice;Pathway interactions;pharmacologic;Phosphorylation;Physiological;Population;Prediabetes syndrome;Prevalence;Prevention;Process;receptor;Regulation;Research;Risk;Role;Signal Transduction;Testing;Text;Therapeutic;trafficking;transcriptome;translational potential;Variant;Work

PROJECT_TITLE: Novel Molecular Determinants of Insulin Clearance

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Osteosarcoma is a bone tumor that primarily affects children, adolescents, and young adults. Here, we will use novel methods to identify biomarkers present in blood that predict tumor behavior at the time of diagnosis. By creating a minimally-invasive blood test to help guide treatment in pediatric osteosarcoma, our results will have the potential to improve management of this devastating disease.

PI_NAMEs: MAKIELSKI, KELLY M (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Address;Adolescent and Young Adult;Affect;aggressive therapy;Award;Behavior;Binding;Bioinformatics;bioinformatics pipeline;Biological;Biological Markers;Biology;biomarker discovery;biomarker identification;biomarker selection;biomarker signature;Blood;Blood Tests;Bone neoplasms;career;Categories;chemotherapy;Child;Childhood Osteosarcoma;Clinical;Clinical Trials;clinically relevant;Data;Dedications;Development;Diagnosis;Diagnostic tests;differential expression;Disease;Disease Progression;Disease remission;exosome;experience;experimental study;Funding;Future;Gene Cluster;Genes;genetic signature;Goals;Human;Immune response;improved;Incidence;Knowledge;Leadership;Machine Learning;machine learning algorithm;Malignant Neoplasms;Membrane;Mentors;Messenger RNA;Methods;microvesicles;minimally invasive;Molecular Profiling;Morbidity - disease rate;mouse model;multidisciplinary;Neoplasm Metastasis;next generation sequencing;Noise;Normal Cell;novel;Operative Surgical Procedures;Osteosarcoma;Outcome;patient stratification;patient subsets;Patients;Pattern;Pediatric cohort;predictive marker;predictive signature;predictive test;primary bone cancer;Probability;Prognosis;prognostic indicator;Progression-Free Survivals;Research;Resources;Risk Marker;risk minimization;Sampling;Scientist;Second Primary Cancers;Sensitivity and Specificity;Serum;Severities;skills;standard of care;Survivors;Systemic Therapy;Testing;Time;Toxic effect;transcriptome sequencing;translational model;translational scientist;Treatment Failure;treatment response;treatment risk;tumor;tumor behavior;Tumor Biology;Work;Xenograft Model;Xenograft procedure;young adult

PROJECT_TITLE: Molecular Signatures of Biologic Behavior in Pediatric Osteosarcoma


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cachexia

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: New therapies aimed at treating chronic illnesses are not always checked for off-target effects on the skeleton. Here we examine if one specific type of new therapy currently in clinical trials for several common chronic diseases has beneficial or harmful effects on bone mass, bone strength and bone repair potential.

PI_NAMEs: ROSEN, VICKI  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: activin A;Address;Adult;Affect;Affinity;Age;Age Months;age related decline;Aging;Anemia due to Chronic Disorder;Binding;Biological Response Modifier Therapy;Biology;BMP2 gene;bone;bone cell;bone fracture repair;bone loss;bone mass;bone repair;bone strength;burden of illness;Cancer Cachexia;Cells;Chronic;Chronic Disease;Chronic Obstructive Pulmonary Disease;Circulation;Clinical Trials;cohort;Complex;Data;Disease;disease model;efficacy evaluation;efficacy testing;Ensure;Event;Exhibits;Extracellular Domain;GDF11 gene;GDF8 gene;Genes;Genetic;Homeostasis;Knowledge;Ligand Binding;Ligands;member;Minerals;Molecular;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;obese patients;Osteoblasts;Osteogenesis;osteoprogenitor cell;Pathogenesis;Pathway interactions;Phenotype;Population;preclinical study;prevent;Proteins;receptor;Reporting;Repression;Resistance;response;Rheumatoid Arthritis;Role;side effect;Signal Pathway;Signal Transduction;skeletal;Skeleton;Therapeutic;therapeutic target;Tissues;transcriptome sequencing;Transforming Growth Factor beta

PROJECT_TITLE: The role of ALK4 signaling in skeletal homeostasis and pathogenesis


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE ADPKD a common inherited kidney disease for which adequate treatment strategies are lacking. Our studies will examine the role of myofibroblasts in cyst growth in ADPKD, and identify novel mechanisms by which the cystic epithelium manipulates myofibroblasts into undergoing autophagy to supply nutrients and promote cyst growth.

PI_NAMEs: RAO, REENA  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Actins;Autophagocytosis;Autosomal Dominant Polycystic Kidney;Catabolic Process;Cell Communication;Cell Nucleus;Cell secretion;Cells;chemokine;Chronic Disease;Conditioned Culture Media;Cyst;Cystic kidney;cytokine;Data;Development;Disease Progression;End stage renal failure;Environment;Epithelial Cell Proliferation;Epithelial Cells;Epithelial cyst;Epithelium;Extracellular Matrix;Fibroblasts;Fibrosis;Functional disorder;Ganciclovir;Gene Deletion;Genes;Glutamine;Goals;Growth;Growth Factor;HIF1A gene;Human;Hypoxia;Hypoxia Inducible Factor;Immune;Impairment;In Vitro;in vitro testing;Inflammation;Inherited;inhibition of autophagy;innovation;interstitial;Kidney;Kidney Diseases;kidney fibrosis;knockout gene;Knockout Mice;Mediating;Metabolism;metabolomics;Modeling;mouse model;Mus;Myofibroblast;novel;Nutrient;Organ;paracrine;Pathogenicity;Pathologic;Play;Polycystic Kidney Diseases;Population;Proliferating;Regulation;Reporting;Research;Research Personnel;Role;Smooth Muscle;System;Testing;Thymidine Kinase;Tissues;Transgenic Organisms;treatment strategy;tumor;uptake

PROJECT_TITLE: Pathogenic reciprocal interplay between cyst epithelium and myofibroblasts in polycystic kidney disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-W(05)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Rural Health;Social Determinants of Health;Vaccine Related

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative This project aims to develop an operational surveillance system based on routine hospital testing to track SARS- CoV-2 transmission and immunity seroprevalence in the community and vulnerable groups over time. The pro- posed statistical methods focus on adjusting sample representation, yielding reliable subgroup estimates, and examining disparities across health outcomes, social determinants, and behaviors. The data collection and anal- ysis procedure will be publicly accessible via a web interface and enhance data harmonization.

PI_NAMEs: SI, YAJUAN  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: acquired immunity;American;Antibodies;Area;asymptomatic COVID-19;Attention;Behavior;Black race;Calibration;clinical predictive model;clinical predictors;Communities;Community Hospitals;Community Surveys;comorbidity;COVID-19;COVID-19 burden;COVID-19 pandemic;COVID-19 patient;COVID-19 testing;Data;Data Analyses;Data Collection;data harmonization;data integration;Data Set;Data Sources;demographics;Disease;Disparity;Electronic Health Record;Epidemic;Ethnic Origin;Foundations;Future;future epidemic;Geography;Government;Guidelines;Health;Health behavior and outcomes;health care service utilization;health disparity;Healthcare;Hospitals;Immunity;Incidence;Indiana;Individual;Inequality;Intervention;Investigation;Knowledge;Link;Locales;Measures;member;Methodology;Methods;Monitor;Outcome;pandemic disease;Pathway interactions;Patients;Phase;Policies;Policy Maker;Population;Prevalence;Procedures;Proxy;Public Health;Race;Reporting;Reproducibility;Research;response;Rural;rural setting;Sampling;SARS-CoV-2 exposure;SARS-CoV-2 immunity;SARS-CoV-2 transmission;screening;Selection Bias;Sensitivity and Specificity;seropositive;Seroprevalences;sex;social;social determinants;social disparities;sociodemographics;socioeconomics;Statistical Data Interpretation;Statistical Methods;Stratification;Subgroup;suburb;symptomatic COVID-19;System;Testing;Time;trend;Vaccination;vaccine access;vaccine-induced immunity;Vaccines;Variant;Viral;viral transmission;Virus Diseases;virus testing;Vulnerable Populations;web based interface;web interface;Work

PROJECT_TITLE: Statistical adjustments of sample representation in community-level estimates of COVID-19 transmission and immunity


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Services;Pediatric;Social Determinants of Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative: To improve care in newly diagnosed Pediatric type 1 diabetes patients we propose using a combination of (4T) Teamwork, Targets, and Technology to maintain Tight glucose control to optimize patient glucose and psychosocial outcomes. We will use an integrated approach to care and develop automated glucose data management and psychosocial monitoring systems that can be translated to other US clinics to optimize glucose control and reduce burden on patients, families, and health care teams. The research outlined in this proposal aims to lower HbA1c, develop glucose data management and communication systems and support the psychosocial challenges of T1D in a program that is practical, sustainable, and translatable to other Pediatric Diabetes clinics in the US.

PI_NAMEs: MAAHS, DAVID MATTHEW (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Automated Clinical Decision Support;Behavioral;blood glucose regulation;Blood Vessels;care delivery;Caring;Childhood;Childhood diabetes;Clinic;clinical practice;Clinical Trials;Communication;Complications of Diabetes Mellitus;Data;data communication;data management;design;Detection;diabetes control;diabetes education;diabetes management;Diabetes Mellitus;Diagnosis;Dose;Education;Educational process of instructing;efficacy evaluation;Failure;Family;flexibility;follow-up;Glucose;Glycosylated hemoglobin A;Goals;Habits;Health Policy;Healthcare;improved;innovation;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;International;Intervention;Literature;Medical Care Team;Methods;Monitor;multidisciplinary;Newly Diagnosed;Patient Outcomes Assessments;patient response;Patients;pediatric health outcomes;Personal Satisfaction;personalized management;Physiological;Population;primary outcome;Procedures;process improvement;programs;Provider;psychosocial;Psychosocial Assessment and Care;psychosocial outcome;Publications;randomized trial;randomized, clinical trials;Recommendation;Reporting;Research;research study;Resources;response;screening program;support tools;System;Technology;telehealth;Testing;Translating;treatment program;trend;United States;Visit

PROJECT_TITLE: Teamwork, Targets, Technology, and Tight Control in Newly Diagnosed Pediatric T1D: 4T Study


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Diabetes

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Glucose homeostasis is maintained primarily by the action of the regulator, insulin and the counterregulators, glucagon, cortisol, epinephrine, and growth hormone, and impaired counterregulation can lead to both hyper- and hypo-glycemia, causing chronic and acute pathologies. Alpha cell dysfunction and impaired glucagon secretion exacerbate type 2 diabetes which has reached epidemic proportions worldwide and places enormous burden on the healthcare system. The mechanisms and contribution of impaired counterregulation to type 2 diabetes and development of hypoglycemia will be studied.

PI_NAMEs: SUBRAMANIAN, VIJAYA  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Acceleration;Acute;aggressive therapy;Alpha Cell;Animals;Apoptosis;Behavior;Beta Cell;blood glucose regulation;Carbohydrates;cell regeneration;Chronic;counterregulation;Data;data modeling;Development;Diabetes Mellitus;diabetic;diabetic patient;Disease;Disease Management;disease model;Disease Progression;Drops;endocrine pancreas development;Endosomes;Epidemic;Epinephrine;Etiology;Event;experience;falls;Fasting;fasting glucose;Functional disorder;Glucagon;glucagon-like peptide 1;Gluconeogenesis;Glucose;glucose disposal;glycogenolysis;Goals;Healthcare Systems;Homeostasis;Hormones;Hour;Hydrocortisone;Hyperglycemia;Hypoglycemia;Impairment;Ingestion;inhibitor;insight;Insulin;Insulin Resistance;insulin secretion;Investigation;Liver;Longitudinal Studies;mathematical model;Mediating;Modeling;Nature;Non-Insulin-Dependent Diabetes Mellitus;OGTT;Pathology;Patients;Persons;Plasma;Play;Polycystic Ovary Syndrome;Prediabetes syndrome;Reactive hypoglycemia;Recovery;Regulation;response;Role;Signal Transduction;Somatostatin;Somatotropin;Symptoms;Type 2 diabetic;Validation

PROJECT_TITLE: Etiology of Impaired Counterregulation in Glucose Homeostasis: Exploring the Roles of Glucagon, Somatostatin, Cortisol, and Epinephrine through Mathematical Modeling of Oral Glucose Tolerance Tests

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Wound Healing and Care

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Wound healing cost the healthcare system billions of dollars and the current cost is set to increase as the population ages. The ability to improve poorly healing wounds would impact the lives of millions of Americans ranging from patients undergoing scheduled surgeries to patients with accidental injuries or wounds caused by other diseases such as diabetes. The goal of this proposal is to develop materials that can use the body’s immune system to promote regenerative wound healing.

PI_NAMEs: COLLIER, JOEL H;SEGURA, TATIANA  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Acceleration;Accidental Injury;adaptive immune response;Adaptive Immune System;Age;American;Amino Acids;Antibodies;Antibody Formation;Antigens;B-Lymphocytes;Biocompatible Materials;Biological;Biological Assay;biomaterial compatibility;bioscaffold;bone;capsule;CD3 Antigens;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;Chemicals;Cicatrix;cost;crosslink;Crosslinker;Deposition;Diabetes Mellitus;Disease;draining lymph node;enantiomer;Engineering;Extracellular Matrix;Fibrosis;Flow Cytometry;functional loss;Goals;Grant;Growth Factor;Hair follicle structure;Health Care Costs;Healthcare Systems;Helper-Inducer T-Lymphocyte;hydrogel scaffold;Hydrogels;IgG1;immune activation;Immune response;Immune signaling;Immune system;Immunity;Immunohistochemistry;immunoregulation;Implant;implant material;implantation;improved;In Situ;Infiltration;Inflammation;Injury;Innate Immune Response;Innate Immune System;Investigation;ITGAM gene;Knockout Mice;Link;Macrophage;Mediating;Modification;Mus;Muscle;Natural regeneration;Operative Surgical Procedures;particle;Patients;peptide L;Peptides;Phenotype;Population;Porosity;prevent;Process;Production;recruit;regenerative healing;regenerative repair;Regenerative wound healing;repaired;Reporting;response;restoration;Reverse Transcriptase Polymerase Chain Reaction;Role;scaffold;Schedule;Sebaceous Glands;Signal Transduction;Skin;skin regeneration;Skin Tissue;Spleen;Stains;stem cell therapy;stem cells;Structure;subcutaneous;success;Sweat Glands;T-Lymphocyte;Tensile Strength;Testing;Time;tissue regeneration;tissue repair;Tissues;Triage;wound;wound closure;wound healing;wound treatment

PROJECT_TITLE: Engineering Adaptive Immune Responses from Hydrogel Scaffolds to Promote Tissue Regeneration

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: NARRATIVE The development of a globally effective HIV-1 vaccine will require the elicitation of broadly neutralizing antibody responses. As such, our proposed studies in this IPCAVD grant are highly relevant to the development of such a vaccine, as we aim to evaluate in humans self-amplifying mRNA vaccines that express two HIV-1 Env-derived protein immunogens that can initiate the maturation of VRC01-class broadly neutralizing antibodies.

PI_NAMEs: STAMATATOS, LEONIDAS  (contact)

PROGRAM_OFFICER_NAME: POOLE, STEVEN THOMAS

PROJECT_TERMS: Acceleration;Adjuvant;Affinity;Animal Model;Antibodies;Antibody Response;Antigens;B-Cell Antigen Receptor;B-Cell Receptor Binding;B-Lymphocytes;Binding;Clinical;Clinical Protocols;Collaborations;Complex;cost;Cyclic GMP;design;Development;env Gene Products;first-in-human;follow-up;Fred Hutchinson Cancer Research Center;Germ Lines;Goals;Grant;Health;HIV Vaccine Trials Network;HIV-1;HIV-1 vaccine;Human;Human immunodeficiency virus test;Immune response;Immunization;Immunize;immunogenic;immunogenicity;improved;Individual;Infection;Infectious Diseases Research;Investigation;Lead;Length;manufacture;Membrane;Messenger RNA;mouse model;Mutate;nanoparticle;neutralizing antibody;Outcome;Participant;Phase;Phase I Clinical Trials;Positioning Attribute;pre-clinical;preclinical evaluation;Production;programs;Property;Proteins;Qualifying;Receptor Gene;Recombinant Proteins;Recombinants;research clinical testing;Research Institute;Research Project Grants;response;RNA vaccine;safety testing;Self-Examination;Somatic Mutation;Surface;Technology;Testing;Vaccination;Vaccines;Virus

PROJECT_TITLE: Self-amplifying mRNA-based vaccines to elicit VRC01-class bnAbs


PHR: PROJECT NARRATIVE Tissue barriers depend on intercellular junctions that seal the space between adjacent cells. Recent work has shown that i) physiological function requires these barriers to be selectively-permeable; ii) dynamic channels that traverse the intercellular junctions mediate permeability; and iii) pharmacologic modulation of channel activity can effectively treat disease. The absence of necessary tools has prevented further study. The project will develop an innovative device to overcome this obstacle and provide a foundation for future advances.

PI_NAMEs: TURNER, JERROLD R. (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TITLE: Defining single-channel paracellular (tight junction) conductances using nanotechnology

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Accounting;Achievement;Agreement;Antigens;B-Cell Activation;B-Cell Antigen Receptor;Budgets;Clinical;clinical development;Clinical Investigator;cohesion;Collaborations;Communication;Data;Dedications;design;Development Plans;Ensure;Expenditure;Funding;Goals;Grant;HIV-1;IACUC;Individual;Infrastructure;Institution;inter-institutional;Leadership;Legal;material transfer agreement;meetings;Messenger RNA;Monitor;National Institute of Allergy and Infectious Disease;Participant;Policies;Policy Compliance;Preparation;Principal Investigator;product development;programs;Protocols documentation;Publications;Regulation;Regulatory Affairs;Reporting;repository;Research;Research Activity;research clinical testing;Research Project Grants;Resolution;RNA vaccine;Scientific Evaluation;Self-Examination;Site;Structure;success;tool;United States National Institutes of Health

PROJECT_TITLE: Administrative Core