ORG_CITY: MADISON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Log2Lose is a clinical trial that seeks to evaluate whether people lose more weight when they receive small financial incentives for weekly weight loss or diet logging. Study software collects and analyzes weight data from a cellular-connected scale and dietary data from a smartphone dietary application (‘app’). Algorithms analyze these data to determine if participants meet the criteria to receive an incentive. Participants receive a text message about whether they earned an incentive, and, if so, receive payment on a debit card.

PI_NAMEs: CADMUSBERTRAM, LISA ANNE (contact);VOILS, CORRINE

PROJECT_TERMS: Address;adult obesity;Algorithms;arm;automated algorithm;Behavioral;Blood Pressure;Body Weight;Body Weight decreased;Cause of Death;Cellular Phone;Clinical;Clinical Trials;clinically significant;Communities;Computer software;cost;cost effective;cost effectiveness;cost-effectiveness ratio;Data;design;Diabetes Mellitus;Diet;dietary;Economics;Educational process of instructing;efficacy evaluation;Environment;evidence base;extrinsic motivation;financial incentive;four-arm study;future implementation;Goals;Health;Health behavior and outcomes;Heart Diseases;improved;Incentives;incremental cost-effectiveness;Individual;Intervention;intervention cost;intervention effect;intrinsic motivation;Joints;Kidney Diseases;Maintenance;Malignant Neoplasms;Measures;Mediating;Monitor;Obesity;Outcome;Participant;participant retention;Patient Self-Report;Patients;payment;Persons;Pharmaceutical Preparations;Phase;Population;population health;Prevalence;primary endpoint;Probability;Process;program costs;Program Effectiveness;programs;Qualifying;Quality of life;Randomized;recruit;Research;Respiratory Disease;Rewards;Risk;Role;Secure;Single-Blind Study;Site;Stroke;success;Technology;Testing;Text Messaging;Time;Weight;weight loss intervention;weight loss program;weight maintenance;Weight maintenance regimen

PROJECT_TITLE: (1/2) Log2Lose: Incenting weight loss and dietary self-monitoring in real-time to improve weight management


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Microbiome;Natural Products;Neurosciences;Serious Mental Illness

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Major Depressive Disorder (MDD) is a common mental disorder which is poorly understood and inadequately treated. Research investigating alternative pathways involved in the etiology and pathogenesis of MDD are important to identify novel therapies to reduce the burden of this disease. In this study, we identify mechanisms by which changes in the gut microbiome contribute to changes in the production of microbial metabolites and alter signaling to the brain in the hopes of identifying novel therapeutic targets.

PI_NAMEs: RAMPERSAUD, RYAN  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Adolescent Psychiatry;Aftercare;anti-depressive agents;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Bacteria;bacterial genetics;Biological Assay;Blood;Blood specimen;Brain;burden of illness;career;career development;cellular targeting;Child Psychiatry;Clinical;clinical implementation;Clinical Research;cohort;Communication;Communities;Complex;depressive symptoms;design;Disease;dysbiosis;Etiology;experience;Feces;Fellowship;Foundations;Functional disorder;Genes;gut microbes;gut microbiome;gut microbiota;gut-brain axis;Health;Immune system;In Vitro;in vitro Assay;Individual;Indoles;Inflammation;Inflammatory;inflammatory modulation;Investigation;Knowledge;Lactobacillus;Link;Major Depressive Disorder;Mediating;Mental Depression;Mental disorders;Mentors;metabolomics;Metagenomics;microbial;microbial community;microbiome;microbiome composition;microbiota composition;microbiota-gut-brain axis;Microglia;microorganism;National Institute of Mental Health;Neurobiology;neurodevelopment;Neuroglia;neuroinflammation;neuropsychiatric disorder;new therapeutic target;novel;novel therapeutics;Organism;pathogen;Pathogenesis;Pathway interactions;Physicians;Plasma;Process;Production;Program Development;Receptor Signaling;Reporter;Reporting;Research;Research Design;Research Personnel;response;restoration;restraint;Role;Route;Sampling;Selective Serotonin Reuptake Inhibitor;Serum;Shotguns;Signal Pathway;Signal Transduction;skills;Source;stool sample;Strategic Planning;Structure;Testing;treatment response;Tryptophan;Tryptophan Metabolism Pathway

PROJECT_TITLE: Gut Microbiota Dysbiosis in Major Depressive Disorder is Associated with Altered Production of Aryl Hydrocarbon Receptor Ligands and Altered Microglia Function

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Rehabilitation;Substance Misuse;Telehealth

ORG_CITY: ORLANDO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: Public Health Narrative Behavioral treatments for alcohol use disorder are generally effective, yet there is a need to improve treatments’ effect size and reduce relapse rate through theoretically-informed adjunctive approaches. The results of this study are expected to lead to the development of a technology assisted intervention to standard outpatient alcohol treatment designed to increase engagement in rewarding substance-free activities that can compete as alternatives to drinking. If efficacy of this intervention is established, this low-cost and accessible intervention has the potential to be incorporated in standard alcohol treatment to improve treatment outcomes such as reduced risk for relapse and other negative consequence.

PI_NAMEs: MESHESHA, LIDIA  (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Abstinence;acceptability and feasibility;active control;Affect;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol testing;alcohol use disorder;Alcohols;Applications Grants;Behavior;Behavior Therapy;Behavioral;brief advice;Cardiovascular Diseases;career;career development;Categories;Cellular Phone;Cognitive Therapy;cost;Data;Data Analyses;design;Development;Development Plans;drinking;Ecological momentary assessment;Effectiveness;efficacy testing;Employment;Enhancement Technology;Environment;Evaluation;experience;Feedback;Focus Groups;Funding;Goals;hands-on learning;Health;Health Personnel;high reward;Human;improved;improved outcome;Individual;Injury;innovation;interest;Intervention;Interview;Life;Link;Liver diseases;Maintenance;Malignant Neoplasms;Mentored Patient-Oriented Research Career Development Award;Mentors;Metadata;Methodology;mhealth interventions;mobile computing;Monitor;Moods;National Institute on Alcohol Abuse and Alcoholism;Neurobiology;novel;Outpatients;Participant;Patient Monitoring;Patient Self-Report;Patients;Phase;pilot trial;preventable death;prototype;Psychological reinforcement;Public Health;Questionnaires;Randomized;Recovery;reduced substance use;reinforcer;Relapse;relapse risk;Religion;Reporting;Research;research and development;Research Personnel;Resources;Rewards;Role;Sampling;Series;smartphone application;sobriety;social cognitive theory;Social Network;substance misuse;Suggestion;Technology;therapy design;Time;Training;treatment as usual;treatment center;treatment effect;Treatment Efficacy;Treatment outcome;usability

PROJECT_TITLE: Mobile Health Intervention to Increase Substance-Free Activities During Alcohol Treatment

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Osteoporosis;Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Current treatments for medication related osteonecrosis of the jaw (MRONJ), a serious side effect of antiresorptive medications that can result in devastating pain and morbidity, are mostly empirical and often require major surgery. In this application, we investigate early changes during MRONJ, with the ultimate goal of uncovering mechanistic pathways that lead in MRONJ pathogenesis. Our research could lead to novel diagnostic and therapeutic approaches that can reduce the incidence, severity, and progression of the disease.

PI_NAMEs: TETRADIS, SOTIRIOS  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Address;Alveolar;Angiogenesis Inhibitors;Animal Model;Animals;Area;bisphosphonate;Blood Vessels;bone;Bone necrosis;Bone Resorption;Bone Resorption Inhibition;Cells;Cessation of life;Clinical;collagenase 3;Control Animal;Cytoplasm;Cytoprotection;Data;debilitating pain;Development;Diagnosis;Disease;Disease Progression;Dose;Early Diagnosis;Early Intervention;Epithelium;Exposure to;Fright;Functional disorder;Genes;Goals;healing;Healthcare;heme oxygenase-1;HMGB Family Gene;HMGB1 gene;Homeostasis;Hypoxia;Immune response;Impairment;improved;Incidence;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;inhibitor;insight;Ischemia;Jaw;Lead;Lesion;Macrophage;Malignant Neoplasms;Medication Management;migration;Modeling;Morbidity - disease rate;Mucous Membrane;Necrosis;novel;novel diagnostics;novel therapeutic intervention;Operative Surgical Procedures;Oral cavity;Osteoclasts;Osteocytes;Osteoporosis;Outcome;Oxidative Stress;Oxidative Stress Induction;Pain;parent grant;Pathogenesis;Pathway interactions;Patient Care;Patient Compliance;Patients;Periapical Diseases;Pharmaceutical Preparations;pharmacologic;Phenotype;prevent;Prevention;Publishing;Reporting;Research;Role;Scientist;Severities;side effect;Signal Transduction;Site;skeletal disorder;soft tissue;Surface;Testing;Therapeutic Intervention;therapeutically effective;Tissues;Tooth Diseases;Tooth Extraction;Tooth structure;Transforming Growth Factor beta;translational study;Vascular Cell Adhesion Molecule-1;Vascular Endothelial Growth Factors;Zoledronic Acid

PROJECT_TITLE: Pathophysiologic mechanisms during initiation of medication related osteonecrosis of the jaws

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Cholera is a devastating diarrheal illness responsible for severe morbidity and mortality in developing countries around the world. These proposed studies will characterize Vibrio cholerae-gut microbiome interactions during V. cholerae infection, with the goal of better understanding V. cholerae stress responses and pathogenesis and, potentially, discovering novel treatment and prophylactic interventions for cholera.

PI_NAMEs: HSIAO, ANSEL ;ZHU, JUN  (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Adult;Affect;aminoguanidine;Animals;Antibiotics;biological adaptation to stress;chemical property;Cholera;Cholera Toxin;commensal microbes;Complex;Cysteine;Developing Countries;Diarrhea;diarrheal disease;dinitrosyl iron complex;Disease Resistance;Duodenum;Enzymes;Escherichia coli;Etiology;gastrointestinal function;Gene Expression;Genes;Genomic Islands;Germ-Free;Goals;Grant;Growth;gut microbes;gut microbiome;gut microbiota;Human;Human Microbiome;human pathogen;Immune response;In Vitro;in vivo;Infection;inhibitor;Intervention;Island;Lactobacillus;member;Metagenomics;Microbe;Microbial Biofilms;microbiome;microbiome composition;microorganism interaction;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Nitric Oxide;Nitrogen Oxides;nitrosative stress;NOS2A gene;novel;Outcome;pathogen;Pathogenesis;Pathogenicity;Persons;Poison;Post-Translational Protein Processing;Predisposition;Process;Production;prophylactic;protective effect;Protein S;Proteins;Proteomics;Reactive Nitrogen Species;Regulation;Repression;Research;resident commensals;Resistance;resistance mechanism;response;Risk Factors;Role;Series;Shapes;Site;Small Intestines;Stress;Structure;Tissues;transposon sequencing;Variant;Vibrio cholerae;Vibrio cholerae infection;Virulence;Virulence Factors;virulence gene;Wild Type Mouse

PROJECT_TITLE: Vibrio cholerae antinitrosative stress defenses and gut microbiome interaction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-R(02)M]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Osteogenesis Imperfecta;Pediatric;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Short stature is a major symptom of osteogenesis imperfecta (OI), a genetic bone disorder; however the mechanism of developing growth deficiency remains unknown. In this proposal, we will determine whether dysfunction of cartilage cells plays a critical role in growth deficiency of OI. The outcome of the proposed studies will advance our understanding of the pathogenesis underlying growth impairment and lead to the development of novel therapies to remedy growth deficiency in OI.

PI_NAMEs: OTSURU, SATORU  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: 3-Dimensional;Address;Affect;angiogenesis;autosomal dominant mutation;autosome;biological adaptation to stress;bisphosphonate;bone;Bone Diseases;bone fragility;Bone Growth;Bone Marrow;cartilage cell;Cartilage Diseases;Cell Separation;cell type;Cells;Cellular Stress;Chest;Chondrocytes;clastogenesis;Collagen;Collagen Gene;Data;Defect;Development;Drug Targeting;effective therapy;Endoplasmic Reticulum;endoplasmic reticulum stress;Environment;Epiphysial cartilage;Event;experimental study;Exposure to;Functional disorder;Gene Expression Profiling;Genes;Genetic;Genetic Diseases;Growth;Height;Histologic;Histology;Hypertrophy;Immunoelectron Microscopy;Immunofluorescence Immunologic;Impairment;improved;In Situ;In Vitro;innovation;laser capture microdissection;Length;long bone;Mesenchymal;Mesenchymal Differentiation;mineralization;Modeling;Mus;Musculoskeletal;Mutate;Mutation;novel therapeutics;Osteoblasts;Osteoclasts;Osteogenesis;Osteogenesis Imperfecta;Outcome;Pathogenesis;Pathway interactions;Patients;Phenotype;Phenylbutyrates;Physiologic Ossification;Play;prevent;Process;Production;Proliferating;Proteins;Reporting;Respiratory Failure;response;Role;Secondary to;skeletal;spine bone structure;Stains;standard care;stem;Stromal Cells;Symptoms;System;Techniques;Testing;Therapeutic;Tissues;transdifferentiation;Transplantation;Wild Type Mouse

PROJECT_TITLE: Mechanism of growth deficiency in dominant forms of osteogenesis imperfecta

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative: Cranial trauma, tumor invasion, cerebrovascular disease, and brain surgeries all can cause defects to the dura mater. Xenogeneic grafts, when properly treated and handled, have the potential to preserve the overall architecture of the matrix and provide enhanced structural support. This study aims to answer the question “Do acellular xenogeneic dura grafts elicit a less deleterious immune response than naturally derived commercial grafts and maintain structural integrity over the long term for in vivo studies?”

PI_NAMEs: WILLIAMS, LAKIESHA NICOLE (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Address;Adhesions;Antibodies;Antigen Presentation;Architecture;Biological;Brain;brain surgery;Cadaver;Cell Proliferation;Cell Survival;Cell-Matrix Junction;Cephalic;Cerebrospinal Fluid;Cerebrovascular Disorders;Chronic Headaches;Cicatrix;Clinic;Clinical;Collagen;Collagen Fiber;Collagen Type I;Connective Tissue;Consensus;Defect;Dura Mater;Elastic Fiber;Elastin;Electron Microscopy;Euthanasia;Evaluation;Extracellular Matrix;Extracellular Matrix Proteins;Extravasation;Failure;Family suidae;Fibroblasts;Freeze Drying;Genetic;Gold;Growth Factor;Health;Histologic;Human;immune cell infiltrate;Immune response;Immunologics;Implant;implantation;improved;In Vitro;in vitro Assay;in vitro Model;in vivo;infection risk;Inflammation;Instruction;Knowledge;Laminin;Leukocytes;Libraries;Life;light microscopy;Macrophage;Maps;Mechanics;Metabolic;Modeling;Morbidity - disease rate;mortality;neutrophil;patched protein;Patient Selection;Patients;Performance;Perfusion;Polymers;pre-clinical;preservation;pressure;primary outcome;Procedures;Process;Proliferating;Property;Proteins;PTPRC gene;Rattus;repaired;replacement tissue;Research;response;Rodent;Role;Rupture;scaffold;seal;Secure;Site;Source;Stains;Stretching;Structure;Subdural Hematoma;success;Surgeon;Testing;Time;tissue fixing;tissue regeneration;Tissues;Trauma;Tumor Cell Invasion;Work;wound healing

PROJECT_TITLE: In vitro and in vivo assessments of xenogeneic cranial dura mater and naturally derived commercial dural grafts

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Vaccine Related

ORG_CITY: South San Francisco

ORG_NAME: CENTIVAX INC

PHR: NARRATIVE Between 81,000 and 138,000 people die each year from snakebite envenomation, and up to 400,000 are left permanently disabled, making snakebite envenomation a major risk to global health. Currently available antivenoms require correctly identifying the snake species, have a short shelf-life, cause unwanted side effects, and are targeted only to individual species. This proposal will develop a universal, thermostabilized, broad- spectrum, human-derived antivenom capable of treating snakebite envenomation from multiple species, in the field, through intramuscular dosing, using dual chamber syringes or auto-injectors, thereby increasing protection in populations such as the U.S. military and rural communities worldwide.

PI_NAMEs: GLANVILLE, JACOB  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Adverse event;Adverse reactions;American;Anaphylaxis;Animal Sources;Animals;Antibodies;Antibody Repertoire;Antivenins;Bite;Cell Line;Cells;Cessation of life;Clinical Trials;commercialization;cost;Dangerousness;Development;disabled;Dose;early experience;early onset;Elapidae;Equus caballus;experimental study;Exposure to;Fab Immunoglobulins;Family;Formulation;Freeze Drying;Funding;Future;Generations;global health;Goals;Grant;Half-Life;Health;Health Personnel;Homologous Gene;Human;human monoclonal antibodies;humanized antibody;Immune;Immune system;Immunity;Immunization;Immunize;immunogenicity;Immunoglobulin G;in vivo;Individual;Infusion procedures;Injury;innovation;Intramuscular;Intravenous;Intravenous infusion procedures;lead candidate;lead optimization;Left;Legal patent;Libraries;Life;male;manufacture;Medical;melting;member;Methodology;middle age;Military Personnel;Monitor;monomer;Mus;Neurotoxins;neutralizing antibody;neutralizing monoclonal antibodies;Patients;Persons;Phase;Phenotype;Phylogenetic Analysis;Plasma;Population;Production;Protocols documentation;Recombinants;Recording of previous events;Refrigeration;Reporting;Research Proposals;Risk;Robotics;Route;Rural Community;scale up;Serotherapies;Serum;Serum Sickness;Sheep;side effect;single cell sequencing;Small Business Innovation Research Grant;Snake Bites;Snake Venoms;Snakes;Source;Syringes;Technology;Temperature;thermostability;Time;Toxin;Training;United States National Institutes of Health;Vaccines;Venoms;Vial device;Viperidae;Work

PROJECT_TITLE: Development of World's First Fully Human Broad Spectrum Anti-Snake Venom

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-U(10)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Long-term learning and memory systems known to be crucial for the acquisition of complex skills are an almost completely untapped route to understanding the mechanisms and specific factors that lead to better math outcomes crucial to individual prosperity and well-being. We propose an accelerated, repeated-measures longitudinal project examining how neurocognitive measures of specific long-term memory systems contribute to learning-related changes in specific math outcomes in 1st through 5th grade children at multiple levels of analyses (brain and behavior). By revealing specific, directional links between memory and math systems, this work will also help determine which memory systems would be most effective targets for future randomized controlled trials, thereby increasing the probability of developing successful interventions aimed at improving outcomes in children with and without math learning difficulties.

PI_NAMEs: EVANS, TANYA MARIE (contact);LYONS, IAN M

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Academic achievement;Acceleration;Adult;age group;Arithmetic;Attention;Basal Ganglia;Behavior;behavior measurement;Behavioral;Brain;Child;Cognitive;cognitive skill;cohort;Complex;Data;Development;Education;elementary school;fifth grade;follow-up;fourth grade;Future;Healthcare;improved;improved outcome;Individual;individual variation;insight;Instruction;Intake;Intervention;Investigation;Knowledge;Language;Learning;Learning Difficulty;Learning Skill;Link;long term memory;longitudinal design;Longitudinal Studies;mathematical ability;mathematical difficulties;mathematical learning;mathematical theory;Mathematics;Mathematics Curriculum;Measures;medial temporal lobe;Memory;Modeling;neural;Neurocognitive;neuroimaging;neuromechanism;Occupations;Outcome;Personal Satisfaction;Play;Probability;procedural memory;Randomized, Controlled Trials;Reading;remediation;Research;Research Design;Retrieval;Role;Route;Shapes;Short-Term Memory;skill acquisition;skills;standardize measure;successful intervention;Support System;System;Techniques;Testing;Time;Treatment Efficacy;Variant;Work

PROJECT_TITLE: Longitudinal Investigation into Declarative and Procedural Memory Brain Systems Supporting the Development of Math Skills

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Mucosal alterations in the microbiome and chronic local inflammation are believed to play major roles in the development of rheumatoid arthritis (RA) and other autoimmune diseases in humans. Studies of this process have identified specific mucosal changes which appear to drive the earliest phases of autoimmunity and eventually result in tissue destruction. This proposal will support studies of the mucosal phenotypes present that appear causally related to rheumatic and autoimmune disease initiation and evolution in cohorts of informative subjects. These tasks will be accomplished through access to data and biolological samples, as well as enrichment programs and pilot grants to facilitate the interest and development of early career investigators who will make important discoveries going forward.

PI_NAMEs: HOLERS, VERNON MICHAEL (contact)

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: Attention;Autoantigens;Autoimmune biomarker;Autoimmune Diseases;Autoimmunity;biobank;biomarker development;biomarker identification;Blood specimen;career;Cell Communication;Cells;Chronic;CLIA certified;Clinical;clinical care;cohort;Collaborations;Colorado;commercialization;Communication;complex data;Computer Analysis;Consultations;Data;Data Analyses;data management;Data Science;Data Science Core;Data Set;design;Development;Diagnostic;Direct Costs;direct patient care;discount;Disease;disease classification;dysbiosis;early detection biomarkers;Education;Environment;Epidemiology;Epithelium;Evolution;Funding;Future;Goals;Grant;Grant Review;Healthcare Systems;Human;human disease;Immunobiology;Immunologic Markers;Immunologic Techniques;Immunology;improved;improved outcome;Individual;Inflammation;Inflammatory;Infrastructure;innovation;insight;Institution;interest;Investments;Letters;Medicine;member;Mesenchymal;metabolome;metabolomics;Methodology;Methods;microbial;microbiome;microbiome analysis;mid-career faculty;Mission;Molecular;Mucosal Immune Responses;Mucosal Immune System;mucosal site;Mucous Membrane;Newsletter;novel;novel marker;novel strategies;novel therapeutics;Online Systems;Outcome;outreach;Participant;Pathogenesis;Pathway interactions;Patient Care;Patients;Peripheral;peripheral blood;personalized medicine;Phase;Phenotype;Play;Population;Population Sciences;Population Study;Populations at Risk;pre-clinical;prevent;Process;professor;Program Development;programs;recruit;Research;research and development;Research Personnel;Resources;Rheumatism;Rheumatoid Arthritis;Role;Sampling;Sampling Studies;Scholars Program;Science;Series;Services;single cell technology;skills;social media;Source;Spondylarthropathies;Study Subject;symposium;systemic autoimmunity;systemic inflammatory response;Systemic Lupus Erythematosus;Technology;Technology Assessment;Testing;Therapeutic;therapy development;Tissue Sample;Tissues;Training;Translating;Translations;Universities

PROJECT_TITLE: Center for Mucosal Immunobiology and Rheumatic Disease Pathogenesis


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Pediatric;Substance Misuse

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE In day-to-day life, we must select actions by envisioning the likely outcomes of our behaviors. The capacity for this prospective decision making improves during adolescent development, on the one hand, and is imperiled by addictive drugs on the other. This proposal will help to understand the developmental-biological factors controlling goal-seeking behavior; new information could ultimately help combat drug misuse.

PI_NAMEs: GOURLEY, SHANNON LEIGH (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Ablation;Adolescence;Adolescent;Adolescent Development;Adult;Affinity;Amygdaloid structure;Award;Behavior;Behavior Control;behavior test;Biological Factors;Brain-Derived Neurotrophic Factor;Cells;cerebral atrophy;Choice Behavior;Cocaine;Cognitive;combat;combinatorial;compulsion;Contracts;Decision Making;Dendritic Spines;design;Development;Dominant-Negative Mutation;drug misuse;Employment;Enterobacteria phage P1 Cre recombinase;Failure;flexibility;Food Poisoning;FOS gene;Funding;Genetic;genetic approach;Goals;Growth;Health;high reward;Hippocampus;Human;improved;Individual;Infusion procedures;insight;interest;Knowledge;Lead;Life;Link;Maps;Medial;Mediating;Memory;memory retrieval;Mental Health;Morphology;Mus;National Institute of Drug Abuse;neural;neurodevelopment;Neuromodulator;Neurons;neuroregulation;neurotrophic factor;novel;Organism;Outcome;Output;overexpression;Pattern;Pharmaceutical Preparations;Phosphotransferases;Population;Process;prospective;Protein Isoforms;Psychopathology;Psychoses;receptor;Reporting;Research;response;Restaurants;Retrieval;reward processing;Rewards;Rodent;Role;Signal Transduction;social;stressor;Structure;Substance Use Disorder;Supporting Cell;System;Tamoxifen;Testing;Time;Transgenic Mice;Tropomyosin;Update;Viral Vector

PROJECT_TITLE: Neurotrophic and ontogenic factors in medial orbitofrontal cortical function

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

PROJECT_TERMS: Administrator;Advertisements;Advisory Committees;Annual Reports;Area;Autoimmune Diseases;Award;base;Biological;biomarker development;Blood Cells;Budgets;career;career development;catalyst;Center Core Grants;Chronic;Clinical;cohort;Collaborations;Colorado;Communication;Communication Programs;Communities;Consultations;Core Facility;cost;Data;Development;direct application;discount;Disease;Down's Syndrome;dysbiosis;experience;Faculty;Financial Support;Foundations;Funding;Goals;Grant;Growth;host-microbe interactions;human disease;Human Resources;Immune;immune activation;Immunobiology;improved;Individual;Industry;Inflammation;Infrastructure;innovation;interest;International;Knowledge;Leadership;Letters;medical schools;Medicine;member;Methods;Mission;Modeling;Monitor;Mucosal Immune System;Mucous Membrane;Names;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;new technology;Newsletter;novel;operation;Organ;outreach;Pathogenesis;Pathway interactions;Patients;Phase;preclinical study;predictive marker;Prevention;Process;professor;Program Development;Program Reviews;programs;Reporting;Request for Applications;Research;Research Personnel;Research Support;Resources;Rheumatism;Role;satisfaction;Scholars Program;Self Tolerance;senior faculty;Series;Services;skills;social communication;social media;Specimen;success;Support Groups;symposium;Technology Assessment;therapeutic development;Time;Tissues;Universities;Visit

PROJECT_TITLE: Center for Mucosal Immunobiology and Rheumatic Disease Pathogenesis Administrative Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Cerebrovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Neurosciences;Pediatric;Pregnancy;Rare Diseases;Women's Health Research

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Congenital heart disease is a leading cause of neonatal death and long-term morbidity, including a significant risk of neurodevelopmental impairments. The placenta in pregnancies complicated by moderate and severe fetal heart disease is functionally impaired with a significantly higher burden of pathologic lesions compared to placentas from healthy pregnancies. The connection between the placenta and the developing fetal brain has been elucidated by many recent studies, and this project seeks to understand the influence of placental blood flow on brain development in fetuses with moderate and severe forms of congenital heart disease.

PI_NAMEs: LEON, RACHEL L (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Address;Adult;Affect;analytical tool;Area;arterial spin labeling;Automobile Driving;Basic Science;Blood capillaries;Blood flow;Blood Pressure;Blood Pressure Monitors;Brain;brain abnormalities;brain magnetic resonance imaging;Brain region;brain volume;career development;cerebral autoregulation;cerebral oxygenation;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Child;Clinical;Clinical Research;Clinical Skills;Congenital Abnormality;congenital heart abnormality;Data;Dedications;density;Development;Development Plans;Diagnosis;Doctor of Philosophy;Doppler Ultrasound;Environment;Evaluation;experience;fetal;Fetal Heart;Fetus;Functional disorder;Functional impairment;Funding;Goals;Growth;healthy pregnancy;Heart Diseases;hemodynamics;Histopathology;Hospitals;Human;Image;Imaging Techniques;impaired brain development;Impairment;improved;in utero;in vivo;Infant;innovation;Intervention;Knowledge;Leadership;Left;Lesion;Life;Link;Magnetic Resonance Imaging;Measures;Medical center;Mentors;middle cerebral artery;Morbidity - disease rate;multidisciplinary;Near-Infrared Spectroscopy;Neonatal;Neonatal Mortality;neonate;Neurodevelopmental Impairment;Neurosciences;Obstruction;operation;Outcome;Pathologic;Perfusion;perfusion imaging;perinatal medicine;Persons;Physicians;Physiology;Placenta;Placenta Diseases;Population;postnatal;postnatal period;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;prenatal;programs;Prospective Studies;recruit;Reporting;Research;Research Personnel;Risk;Second Pregnancy Trimester;Signal Transduction;skills;Structure;Structure of umbilical artery;System;Techniques;Testing;Third Pregnancy Trimester;Training;translational medicine;United States National Institutes of Health;Vasodilation;Ventricular;Villous

PROJECT_TITLE: Placental hemodynamic effects on brain development in infants with congenital heart disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Sepsis describes a severe illness caused by infection, and in sub-Saharan African settings, such as Tanzania, sepsis is a common and deadly reason for admission to hospital. Using clinical data and blood samples from Tanzanian adult patients with sepsis, this project will identify the key patient characteristics and the key markers in the bloodstream that will enable classification of sepsis into subtypes that reflect the different biological pathways that lead to the severe illness. By understanding these underlying pathways, this project will advance our progress towards better management strategies tailored to sepsis subtypes, and improved management will eventually lead to decreased risk of death and disability due to sepsis in sub-Saharan Africa.

PI_NAMEs: RUBACH, MATTHEW P (contact)

PROJECT_TERMS: Admission activity;Adolescent;Adoption;Adult;Africa South of the Sahara;African;American;Automobile Driving;Award;Bayesian Analysis;Bayesian Modeling;Bioinformatics;Biological;Blood Circulation;Blood specimen;burden of illness;Caring;Cessation of life;Characteristics;Classification;classifier algorithm;Clinical;Clinical Data;clinical investigation;clinical phenotype;Clinical Research;clinical research site;clinically relevant;Cluster Analysis;cohort;Country;Cryptococcosis;Data;Data Collection;Derivation procedure;Detection;disability;Disease;District Hospitals;Epidemiology;Etiology;Europe;European;Evaluation;Fever;Functional disorder;Future;Gene Expression Profile;Genetic;Genetic Transcription;Goals;Health;Health system;High Prevalence;HIV Infections;Hospital Mortality;Hospitals;Immune response;Immunologics;improved;Income;Infection;Infectious Disease Epidemiology;Infrastructure;Intervention;Investigation;Knowledge;low income country;Mathematics;Methods;Mission;Modeling;Molecular;Morbidity - disease rate;mortality;mortality risk;North America;Observational Study;Outcome;Pathway interactions;patient population;Patients;point of care;Population;Positioning Attribute;precision genomic medicine;precision medicine;Process;prospective;Protocols documentation;randomized trial;Research;Research Personnel;Resource-limited setting;risk stratification;RNA analysis;sample collection;Sampling;Sepsis;Sepsis Syndrome;septic patients;Septic Shock;Severities;Site;Stratification;Syndrome;Tanzania;therapy design;transcriptomics;Triage;Tuberculosis;United States National Institutes of Health;Universities;Validation;Virus Diseases;Whole Blood;Work

PROJECT_TITLE: Sepsis Characterization in Kilimanjaro

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Physical Activity;Physical Rehabilitation;Prevention;Rare Diseases;Rehabilitation

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Lymphoma survivors are increasingly experiencing morbidity and mortality due to cardiovascular events that often result from the anthracycline-based chemotherapy used to treat their cancer. Our team of experienced investigators will test the utility of a patient-centric, individually tailored physical activity intervention implemented throughout chemotherapy to attenuate physical inactivity, reduce fatigue, and preserve exercise capacity, cardiac and cognitive function, strength, and health-related quality of life: all metrics that associate with or reduce cardiovascular risk. By fostering a lifestyle that maintains or increases physical activity and exercise capacity, this project seeks to reduce overall cardiovascular morbidity and mortality of lymphoma survivors and thereby improve their overall survival and quality of life.

PI_NAMEs: HUNDLEY, WILLIAM GREGORY (contact)

PROGRAM_OFFICER_NAME: DIMOND, EILEEN

PROJECT_TERMS: Activities of Daily Living;Address;Adherence;adverse outcome;Aerobic;Animals;Anthracycline;arm;Attenuated;Cancer Center;cancer initiation;Cancer Patient;Cancer Survivor;cancer therapy;Cardiac Output;Cardiac rehabilitation;Cardiopulmonary;Cardiotoxicity;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;chemotherapy;clinical practice;Clinical Trials;Cognitive;cognitive function;Communities;Comprehensive Cancer Center;Data;Data Analyses;design;Enrollment;Event;Exercise;exercise capacity;exercise intervention;exercise intolerance;exercise program;Exercise Tolerance;exercise training;experience;Fatigue;Feedback;Focus Groups;Fostering;functional decline;Functional disorder;Funding;Goals;Health;health related quality of life;Heart failure;heart function;Home;Hospitalization;Human;Immunocompromised Host;Impaired cognition;improved;Individual;individualized medicine;insight;Instruction;Intervention;intervention refinement;Interview;Knowledge;Left Ventricular Dysfunction;Left Ventricular Function;Life Style;Lymphoma;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Methods;Morbidity - disease rate;mortality;Myocardial dysfunction;Non-Hodgkin's Lymphoma;non-Hodgkin's lymphoma patients;North America;novel;Outcome;Oxygen;Participant;participant enrollment;Patients;Peripheral;Phase;Physical activity;Physical Exercise;physical inactivity;Physical Performance;Physical shape;Physiological;preservation;primary outcome;Prognosis;programs;Property;Quality of life;Randomized;randomized, clinical trials;Rehabilitation Centers;Research Personnel;screening;secondary outcome;sedentary lifestyle;Structure;Survivors;Testing;Time;Translating;Travel;treadmill;Treadmill Tests;Treatment-Related Cancer;trend;United States National Institutes of Health;Walking

PROJECT_TITLE: Improving Exercise Capacity with a Tailored Physical Activity Intervention in Lymphoma Patients Undergoing Treatment


PI_NAMEs: DEANE, KEVIN  (contact)

PROJECT_TERMS: Address;Area;Autoimmune Diseases;Awareness;biobank;Biological Markers;Biology;Blood;Budgets;career;catalyst;Chronic;Clinical;Clinical Research;cohort;Collection;Colorado;Data;data management;data repository;Data Science;data sharing networks;Development;Diagnosis;didactic education;Dietary intake;Disease;disease natural history;dysbiosis;Environmental Exposure;Evaluation;Future;Human Subject Research;Immunobiology;Individual;Inflammation;Inflammatory Bowel Diseases;innovation;Institutional Review Boards;Insulin-Dependent Diabetes Mellitus;Joints;Leadership;lectures;Medical History;member;Mind;Mucosal Immune System;mucosal site;Mucous Membrane;Natural History;Organ;Outcome;Outcome Assessment;outreach;Pain;Pathogenesis;Performance;Personal Satisfaction;Phase;Population Sciences;predictive marker;Prevention;Prevention strategy;Process;programs;recruit;Reporting;Research;Research Design;Research Personnel;Resources;Rheumatism;Rheumatoid Arthritis;Role;Sampling;Self Tolerance;Series;Site;skills;social media;Spondylarthritis;Symptoms;Tobacco use;Training;Universities;website development;Work

PROJECT_TITLE: Core 1


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Progressive supranuclear palsy is a neurodegenerative disorder characterized by the presence of abnormal tau protein in the brain in which patients can present with a number of different clinical syndromes. In this longitudinal study we will determine whether the different progressive supranuclear palsy syndromes show different patterns of abnormalities on brain imaging and different distributions of tau at autopsy. The findings will improve our understanding of the neurobiology of these syndromes and will be critically important to allow the appropriate targeting and monitoring of future therapies for progressive supranuclear palsy.

PI_NAMEs: JOSEPHS, KEITH A;WHITWELL, JENNIFER LOUISE (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Address;Anatomy;Apraxia;Atrophic;Autopsy;Behavior;Behavioral;Biological Markers;Brain;Brain imaging;Brain region;Brain Stem;brain tissue;Characteristics;Classification;Clinical;Data;Deglutition Disorders;Deposition;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;Evaluation;Evolution;Exhibits;experience;falls;Freezing;Future;Gait;gaze palsy;Goals;Grant;Heterogeneity;Impairment;improved;indexing;interest;Knowledge;Language;Ligands;Limb structure;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Modality;Modeling;Monitor;Movement Disorders;Multimodal Imaging;multimodal neuroimaging;multimodality;Nerve Degeneration;neural;neurobiological mechanism;Neurobiology;Neurodegenerative Disorders;neuroimaging;Neurologic;neuropathology;oculomotor;Parkinsonian Disorders;Pathologic;Pathology;Patient Recruitments;Patients;Pattern;Positron-Emission Tomography;posture instability;prognostic;Progressive Supranuclear Palsy;Proteins;Publishing;rate of change;recruit;Research;Research Personnel;research study;Societies;Speech;Standardization;Symptoms;Syndrome;tau mutation;tau Proteins;Time;treatment effect;treatment trial;uptake;Variant;white matter;Work

PROJECT_TITLE: Longitudinal Multi-modal Imaging in Progressive Supranuclear Palsy Syndromes


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: GALVESTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: UTMB OAIC PROJECT NARRATIVE (OVERALL) The University of Texas Medical Branch Claude D. Pepper Older Americans Independence Center (UTMB OAIC) will identify the pathways that lead to functional loss with aging and translate these discoveries into interventions for the promotion of functional recovery and independence in the growing diverse population of older Americans. The UTMB OAIC will use its highly productive and integrated research and training infrastructure to ignite new research, develop novel methodologies, support externally funded research, develop and support new collaborations with other programs and train the future leaders in aging research and geriatrics.

PI_NAMEs: GOODWIN, MD, JAMES S.;MORROW, MELISSA M. (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acute;age related;Aging;American;Animal Model;Animals;Area;behavior change;Biology;Biometry;Capsicum;career;Caring;Cells;Clinical;Clinical and Translational Science Awards;Clinical Research;Clinical Trials;Collaborations;data management;Dementia;Development;early-career faculty;education research;Elderly;Exercise;Fostering;functional decline;functional disability;functional gain;functional improvement;functional independence;functional loss;functional outcomes;Funding;Future;Geriatrics;Gerontology;Hispanic;Hispanic Populations;Home;Hospitalization;Hospitals;Human;Impaired cognition;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Intervention;Leadership;Link;loss of function;Malignant Neoplasms;Medical;Memory;Mentors;Metabolism;Methodology;Methods;Minority;Mission;Modeling;Molecular;multi-site trial;multidisciplinary;muscle aging;muscle metabolism;Nature;Nervous System Disorder;Nervous System Trauma;neurocognitive disorder;neurological recovery;next generation;novel;novel therapeutics;nutrition;Nutritional;older adult;Older Population;opioid use;Outcomes Research;Paper;Pathway interactions;patient oriented;Patients;pharmacologic;Physical Function;Pilot Projects;Population;population health;Population Heterogeneity;Population Research;post stroke;Productivity;programs;Publishing;Recovery of Function;recruit;Rehabilitation Outcome;Research;Research Infrastructure;Research Personnel;Resources;sarcopenia;scale up;Stream;Stroke;stroke model;stroke recovery;technology intervention;Testing;Testosterone;Texas;Training;Training and Education;Training and Infrastructure;Transducers;Translating;translational pipeline;Translational Research;Traumatic Brain Injury;Universities;Woman

PROJECT_TITLE: UTMB Claude D. Pepper Older Americans Independence Center


NIH_SPENDING_CATS: Aging

PI_NAMEs: OTTENBACHER, KENNETH J. (contact)

PROJECT_TERMS: Abbreviations;Address;Aging;American;Applications Grants;Area;Association of American Medical Colleges;Benchmarking;Capsicum;career;career development;Clinical and Translational Science Awards;Collaborations;Communication;Development;Development Plans;early-career faculty;education research;effective intervention;Elderly;Equilibrium;Evaluation;experience;Faculty;Financial Support;Funding;Geriatrics;Gerontology;Goals;Grant;Health;Health Priorities;Hispanic;improved;Individual;Infrastructure;Interdisciplinary Education;interest;Intervention;K-Series Research Career Programs;Latino;Lead;Leadership;Learning;loss of function;Medical;Medical Students;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Metabolism;Minority;Mission;Monitor;multidisciplinary;next generation;older adult;Outcome;Pathway interactions;Physical Function;Population;Preparation;Productivity;Program Development;programs;Qualifying;Recovery of Function;recruit;Research;Research Personnel;Research Support;Resources;responsible research conduct;Role;Scholars Program;Science;Scientist;senior faculty;skills;Structure;student training;success;symposium;Texas;timeline;Training;Training Activity;Training and Education;Training Programs;Translating;translational potential;Translational Research;Traumatic Brain Injury;undergraduate research experience;Universities;Wages;Woman

PROJECT_TITLE: UTMB OAIC Research Education Component (REC)


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Microbiome

PI_NAMEs: LOZUPONE, CATHERINE  (contact)

PROJECT_TERMS: Address;Aerobic Bacteria;Anaerobic Bacteria;Bacteria;career;cell capsule;cell envelope;Cell Physiology;Cell Separation;Cells;cervicovaginal;Collaborations;Colorado;commensal microbes;Communities;Consultations;Data;Data Analyses;data integration;Databases;density;design;Development;diverse data;Experimental Designs;Feces;Fee-for-Service Plans;Flow Cytometry;Gene Expression;Generations;Goals;Homeostasis;host-microbe interactions;Human;human tissue;Immune;Immunobiology;Immunology;In Vitro;Individual;Interdisciplinary Study;interest;Intestinal Mucosa;Intestines;Investments;Libraries;lipidome;lipidomics;liquid chromatography mass spectrometry;Lower respiratory tract structure;Metabolic;metabolome;metabolomics;Metagenomics;metatranscriptomics;method development;Methods;Microbe;microbial;microbial community;microbial host;microbial products;microbiome;microbiota;Mucous Membrane;novel;Nucleic Acids;Oral cavity;Organ;Pathogenesis;Pathway interactions;Phenotype;phenotypic data;Population;Process;Production;Productivity;Research;Research Personnel;Research Support;Resources;response;Rheumatism;Rheumatoid Arthritis;Ribosomal RNA;Role;Sampling;Science;Services;Shotguns;small molecule;Spondylarthritis;Sputum;Statistical Data Interpretation;Statistical Study;Technology;Tissues;trafficking;Training;transcriptome sequencing;Universities;Validation

PROJECT_TITLE: Core 2 - Mucosal Immunobiology Core (MIC)


NIH_SPENDING_CATS: Aging;Patient Safety;Physical Activity

PI_NAMEs: VOLPI, ELENA  (contact)

PROJECT_TERMS: Abbreviations;Adult;Aging;American;Award;Biology;Biometry;Capsicum;career;Caring;clinical care;clinical practice;Clinical Research;clinical research site;clinical training;Clinical Trials;Clinical Trials Network;Collaborations;Communication;Communities;Community Outreach;Data Management Resources;Development;drug discovery;education research;Elderly;Environment;Extramural Activities;Fostering;Funding;Goals;Government;Grant;Growth;Health system;Healthcare;Hispanic;Hospitalization;improved;Infrastructure;innovation;Institution;Intervention;Journals;Leadership;Link;loss of function;Medical;medical schools;meetings;member;Metabolism;Methods;Minority;Modeling;Molecular;Monitor;nutrition;Paper;Pathway interactions;Patient Monitoring;patient safety;Patients;Physical activity;Policies;Population;pre-clinical;pre-clinical research;Process;Productivity;programs;Publishing;Recovery;Recovery of Function;Reporting;Research;Research Personnel;Resource Allocation;Resources;Science;Site;social media;Social support;System;Texas;Time;Training;training opportunity;Transducers;Translating;Translational Research;United States National Institutes of Health;Universities;web site

PROJECT_TITLE: UTMB OAIC Leadership and Administrative Core (LAC)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;Precision Medicine;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE Tools to help physicians tailor treatments to match the biologic aggressiveness and drug sensitivity of each patient’s breast cancer are urgently needed to achieve precision medicine. The proposed research will lay the groundwork for translating a new functional imaging-based, non-invasive approach to assess early response to neoadjuvant endocrine therapy for patients with hormone receptor positive primary breast cancer. A direct method of measuring functional endocrine sensitivity is relevant to the NIH’s mission and is expected to have significant clinical impact by better informing decisions for optimal, individualized therapy and ultimately by reducing breast cancer morbidity and mortality.

PI_NAMEs: FOWLER, AMY  (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: Adjuvant Chemotherapy;adjuvant endocrine therapy;Adjuvant Therapy;Aftercare;Agreement;antagonist;Axilla;Biological;Biological Markers;Breast;Breast Cancer Patient;breast imaging;Breast-Conserving Surgery;care outcomes;chemotherapy;Clinical;Clinical Trials;Data;deprivation;Diffusion;drug sensitivity;efficacy evaluation;Endocrine;Enrollment;ERBB2 gene;Estrogen Receptors;Estrogens;Evaluation;Event;Excision;Functional Imaging;Genes;Goals;Hormonal;hormone receptor-positive;hormone therapy;Hybrids;Image;imaging agent;imaging approach;imaging modality;improved;improved outcome;in vivo;individualized medicine;innovation;Knowledge;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Mammary Neoplasms;Mammography;Measures;Mediating;men;Metastatic breast cancer;Metastatic/Recurrent;Methods;Mission;Modality;molecular subtypes;Morbidity - disease rate;mortality;Multicenter Trials;multiparametric imaging;Mutation;Neoadjuvant Therapy;Newly Diagnosed;novel diagnostics;Operative Surgical Procedures;Outcome;Palpation;Patient-Focused Outcomes;Patients;Perfusion;personalized approach;personalized care;Phase;phase 2 study;Phase II Clinical Trials;Physicians;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;precision medicine;predicting response;Prediction of Response to Therapy;Predictive Value;Prior Therapy;Progesterone Receptors;Progestins;Proliferating;prospective;Protocols documentation;quantitative imaging;radioligand;Reader;receptor;receptor expression;Reference Standards;Research;Resistance;resistance mechanism;response;Safety;Scanning;Signal Transduction;Staging;standard of care;success;Techniques;Testing;tool;Translating;Treatment Efficacy;treatment optimization;Treatment outcome;treatment planning;treatment response;tumor;Tumor Burden;tumor growth;Tumor Markers;tumor xenograft;ultrasound;United States National Institutes of Health;uptake;Woman;Work;X-Ray Computed Tomography;Xenograft procedure

PROJECT_TITLE: Precision Imaging of Breast Cancer for Guiding Neoadjuvant Endocrine Therapy

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Aging;Clinical Research;Patient Safety;Women's Health Research

PI_NAMEs: PADDON-JONES, DOUGLAS  (contact)

PROJECT_TERMS: Abbreviations;acute care;Address;Aging;American;Applications Grants;Area;Biology;Biometry;Capsicum;Clinical and Translational Science Awards;Clinical Research;Collaborations;Data Management Resources;Development;Discipline;education research;Effectiveness;Elderly;Enrollment;Ensure;Extramural Activities;Funding;Goals;Grant;Hispanic;Hospitalization;human subject protection;improved;Individual;innovation;Institution;Institutional Review Boards;Interdisciplinary Study;interest;Intervention;Leadership;Long-Term Care for Elderly;loss of function;Medical;Mentors;Metabolism;Minority;Mission;Modeling;Monitor;multi-site trial;multidisciplinary;Nervous System Disorder;nutrition;older adult;Pathway interactions;Patients;Physical activity;Physical Function;Pilot Projects;Population;Productivity;programs;Recovery;Recovery of Function;Reporting;Research;Research Personnel;Resources;Safety;scale up;Stream;success;Texas;Training;Translating;translational pipeline;Translational Research;United States National Aeronautics and Space Administration;Universities;Woman;Women's Health

PROJECT_TITLE: UTMB OAIC Pilot/Exploratory Studies Core (PESC)


PI_NAMEs: RASMUSSEN, BLAKE B (contact)

PROJECT_TERMS: Abbreviations;age effect;Aging;American;Animal Model;Animals;Applications Grants;Basic Science;biobank;Biological;Biology;Capsicum;Cell Culture Techniques;Cellular biology;Clinical Research;Clinical Trials;Data;Development;Disease;doubly-labeled water;Elderly;Energy Metabolism;experimental study;Fatty acid glycerol esters;Functional disorder;functional gain;functional loss;Funding;Gases;Generations;Glucose;Goals;Grant;Human;Individual;innovation;Institution;Intervention;Isotopes;Knockout Mice;Mass Fragmentography;Mass Spectrum Analysis;Metabolic;metabolic phenotype;Metabolism;metabolomics;Methodology;Methods;MicroRNAs;Molecular;Molecular Biology;Molecular Biology Techniques;Morphology;mouse model;Muscle;muscle aging;Muscular Atrophy;Nicotinamide N-Methyltransferase;novel;novel therapeutics;older adult;Older Population;Pathway interactions;Phenotype;Physical Function;Pilot Projects;Population;Pre-Clinical Model;protein metabolism;Proteins;Recovery;Recovery of Function;Research;Research Personnel;Resources;response;Sampling;sarcopenia;Services;Shipping;skills;success;Testing;Tissues;tool;Tracer;Training;transcriptomics;Translating;Translational Research;Translations;United States National Institutes of Health;WFDC2 gene;Work

PROJECT_TITLE: UTMB OAIC Metabolism and Biology Resource Core 1 (MBRC1)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences

PHR: Narrative / Relevance  One of the longstanding mysteries concerning human memory is how the brain organizes and recalls memories of past experiences. Cognitive theories of memory search and retrieval propose that each memory is encoded into its own unique situational context, that the context of a memory is updated each time we retrieve it, and that this context information guides memory search. The proposed research will combine computational modeling approaches with analysis of direct brain recordings in neurosurgical patients, as well as non-invasive recordings in healthy adults, to bridge these cognitive theories of memory with the neural mechanisms underlying this vital human ability.

PI_NAMEs: KAHANA, MICHAEL JACOB (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TITLE: Associative Processes in Episodic Memory

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Aging;Clinical Research;Nutrition;Patient Safety;Physical Activity;Prevention;Rehabilitation

PROJECT_TERMS: Abbreviations;acute care;Adipose tissue;Aging;American;Aspirin;Behavior Therapy;Behavioral;Biology;Biometry;Biopsy;Body Composition;Capsicum;career development;Caring;Clinic;Clinical and Translational Science Awards;clinical investigation;Clinical Research;Clinical Trials;Communities;Data Management Resources;Development;Dietary Intervention;education research;education resources;Elderly;Electronic Health Record;Emerging Technologies;Ensure;ethnic minority population;Event;exercise intervention;Exercise Test;exercise training;Failure;functional outcomes;Goals;Health;Health Insurance Portability and Accountability Act;Healthcare;Hispanic;Hospitalization;Hospitals;human subject;human subject protection;improved;Individual;Infrastructure;innovation;Intervention;investigator training;Laboratories;Laboratory Research;Leadership;Long-Term Care for Elderly;loss of function;Measurement;Medical;Metabolism;Methodology;Methods;Molecular;Monitor;Multi-Institutional Clinical Trial;Muscle;novel;nutrition;Nutritional;Nutritional status;older adult;Outcomes Research;Participant;Pathway interactions;Patient Admission;patient oriented;patient safety;Patient-Focused Outcomes;Patients;Physical activity;Physical Function;physically handicapped;Pilot Projects;Policies;Population;Population Heterogeneity;Procedures;Productivity;Protocols documentation;racial minority population;Recovery;Recovery of Function;recruit;Regulation;Research;Research Personnel;research study;Research Support;Research Training;Resources;retention rate;Risk Reduction;Running;Safety;satisfaction;screening;Standardization;standardize measure;Teacher Professional Development;Techniques;Technology;Testing;Texas;timeline;Training;Transducers;Translating;Translational Research;Translations;Universities;Update;ward;working group

PROJECT_TITLE: UTMB OAIC Clinical Research Resource Core 2 (CRRC2)


NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Comparative Effectiveness Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention

PI_NAMEs: KUO, YONG-FANG  (contact)

PROJECT_TERMS: Abbreviations;Address;Aging;Algorithms;American;Analysis of Variance;analytical method;Applications Grants;biobank;Biology;Biometry;Biostatistical Methods;Capsicum;Clinical;Clinical Research;Clinical Trials;Collaborations;Community Health;Comparative Effectiveness Research;computer science;computerized data processing;Data;Data Analyses;data infrastructure;data management;Data Management Resources;Data Sources;Databases;design;Development;education research;Elderly;Electronic Health Record;epidemiology study;experience;experimental study;Faculty;faculty mentor;follow-up;functional gain;functional loss;functional outcomes;Funding;Goals;Grant;Heterogeneity;Hispanic;Human Resources;improved;Individual;Informatics;Information Systems;Infrastructure;innovation;Intervention;Intervention Studies;Investigation;Joints;K-Series Research Career Programs;Leadership;Link;Longitudinal Studies;loss of function;Measurement;member;Mentors;Metabolism;Methodology;Minority;Modeling;Monitor;muscle hypertrophy;next generation sequencing;novel;Observational Study;older adult;Outcome;Outcomes Research;Pathway Analysis;Pathway interactions;patient subsets;Patient-Focused Outcomes;Physical Function;Pilot Projects;Play;Population;power analysis;Pragmatic clinical trial;Preparation;Preventive Medicine;Process;Publications;Qualifying;randomized trial;Recovery;Recovery of Function;recruit;Research;research and development;Research Design;Research Methodology;Research Personnel;Research Training;Resource Sharing;Resources;Risk;Role;Sample Size;Sequential Multiple Assignment Randomized Trial;Source;Specimen;Statistical Data Interpretation;Statistical Methods;stem;stroke patient;Systems Analysis;Texas;tool;Training;Translating;Translational Research;trial design;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Visual

PROJECT_TITLE: UTMB OAIC Biostatistics and Data Management Resource Core 3 (BDMRC3)


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE  This proposal seeks to identify the critical physicochemical and structural attributes of a variety of rectal and vaginal semi-solid dosage forms and to develop suitable in vitro performance test methods and method validation strategies for such drug products. This will facilitate the development of in vitro comparative characterization-based bioequivalence approaches for locally-acting rectal and vaginal semi-solid drug products. As a consequence of the proposed research, the regulatory burden will be reduced and the public access to high quality and cost-effective topical rectal and vaginal drug products will be improved.

PI_NAMEs: SHEN, JIE  (contact)

PROGRAM_OFFICER_NAME: KELCHEN, MEGAN

PROJECT_TITLE: In Vitro Based Approaches to Evaluate the Bioequivalence of Locally-Acting Rectal and Vaginal Semi-Solid Drug Products


NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Idiopathic pulmonary fibrosis (IPF) is an incurable, aging-associated, and fatal fibrotic lung disease associated with lung epithelial cell damage and abnormal activation of lung fibroblasts and myofibroblasts. The development of therapies for IPF relies on the comprehensive understanding of lung fibrosis resolution pathways. The studies in this proposal will elucidate the role of ubiquitin E3 ligase Nedd4L in BMP4/BMPRII-mediated myofibroblast de-differentiation and fibrosis resolution.

PI_NAMEs: ZHAO, YUTONG  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Ablation;aging related;Architecture;Back;BMP4;BMPR2 gene;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;cell injury;Cells;Chronic;Cicatrix;Data;Development;Docking;Down-Regulation;effective therapy;Epithelial Cells;Exhibits;Extracellular Matrix;Failure;Fibroblasts;Fibrosis;fibrotic lung;fibrotic lung disease;gain of function;Genetic;healing;idiopathic pulmonary fibrosis;Impairment;Injury;Knowledge;Link;Lipid Peroxidation;loss of function;Lung;lung development;Lung Diseases;Lysosomes;Mediating;Modeling;Molecular;Mus;Myofibroblast;novel;novel therapeutic intervention;overexpression;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Play;Polyubiquitin;Polyubiquitination;prevent;Production;Property;protein function;Proteins;proteostasis;Pulmonary Fibrosis;Regulation;repaired;Resolution;response;restoration;Role;Scheme;Signal Induction;Signal Pathway;Signal Transduction;Signaling Protein;Site;success;System;Testing;Therapeutic;therapy development;Transforming Growth Factors;ubiquitin-protein ligase;Ubiquitination;Up-Regulation

PROJECT_TITLE: Molecular regulation of BMPRII stability in lung fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Prevention;Screening and Brief Intervention for Substance Misuse;Substance Misuse

ORG_CITY: SYRACUSE

ORG_NAME: SYRACUSE UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Alcohol is a significant problem in HIV care; novel intervention strategies are needed to decrease alcohol use and improve co-morbid psychological symptoms among people with HIV (PWH). The goal of this application is to conduct a remote, randomized clinical trial (RCT) of a brief, telephone-delivered Acceptance and Commitment Therapy (ACT) intervention to determine its efficacy relative to a standard brief alcohol intervention (BI). If successful, this intervention will have broad implications for implementation in HIV and other integrated care settings.

PI_NAMEs: WOOLF-KING, SARAH E (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Adherence;Adult;Affect;Aftercare;Alcohol abuse;alcohol comorbidity;Alcohol consumption;alcohol intervention;alcohol related problem;alcohol use disorder;Alcohols;Anxiety;Attention;Behavior;Behavioral;behavioral health;Behavioral trial;Biological Markers;brief alcohol intervention;Caring;chronic pain;comorbidity;Continuity of Patient Care;Control Groups;depressive symptoms;Diagnostic;diagnostic strategy;drinking;Drug usage;experience;Feeling;follow-up;functional outcomes;Goals;HIV;HIV therapy;improved;integrated care;Intervention;Literature;Measures;Mediating;Mediator;Mental Depression;Mental disorders;Mental Health;Meta-Analysis;mindfulness;mortality;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;Patient Self-Report;Persons;phosphatidylethanol;Population;Process;psychologic;psychological outcomes;psychological symptom;Randomized;randomized, clinical trials;reduced alcohol use;Reporting;Review Literature;Risk;Sampling;skills;Smoking;smoking cessation;Stress;substance use;Substance Use Disorder;success;syndemic;telephone delivery;Therapeutic Intervention;Thinking;treatment effect;United States National Institutes of Health;Viral

PROJECT_TITLE: Acceptance and Commitment Therapy for HIV+ hazardous drinkers: A randomized clinical trial

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Astrocytes are non-neuronal cells which are critical components of cortical circuits underlying learned behavior, yet their mechanistic role in modulating synapses to influence neuronal and circuit plasticity is poorly understood. We will use high-resolution imaging of astrocyte and neuronal activity in motor cortex of behaving mice learning a skilled movement, combined with computational analyses and state-of-the-art tools for modulating astrocyte function, to define how astrocytes influence learning in motor cortex circuits. These findings will provide insight into how dysregulation of astrocyte function may influence brain dysfunction.

PI_NAMEs: SUR, MRIGANKA  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Acute;Address;Affect;Astrocytes;Beds;Behavior;Brain Diseases;brain dysfunction;Calcium;Calcium Signaling;cell type;Complex;Computer Analysis;CRISPR/Cas technology;Cues;Data;Development;differential expression;Forelimb;gamma-Aminobutyric Acid;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic;Glutamates;Goals;high resolution imaging;in vivo;Individual;insight;knock-down;learned behavior;Learning;Mediating;Methods;Modeling;Molecular;Motor;motor behavior;Motor Cortex;motor learning;Motor Neurons;Movement;Mus;Neuroglia;neuronal circuitry;Neuronal Plasticity;Neurons;neurotransmission;neurotransmitter uptake;Neurotransmitters;novel;optogenetics;Pattern;Physiological;prevent;Process;response;Role;Shapes;skills;Sodium;spatiotemporal;Specific qualifier value;Stereotyping;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;tool;Training;transmission process;uptake;Viral

PROJECT_TITLE: Astrocyte-Neuron Circuits Underlying Cortical Mechanisms of Learned Behavior

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative The proposed project seeks to determine best practices for recruiting and engaging women living in the Deep South who are vulnerable to HIV infection into a digital cohort, with the goal of evaluating factors that contribute to STI and HIV infection and HIV pre-exposure prophylaxis use. Outcomes from this study will help identify gaps in Ending the HIV Epidemic initiatives in reaching Southern women at highest risk for acquiring HIV and guide future intervention development. This project is responsive to national priorities outlined by the Ending the HIV Epidemic initiative as well as the National Institute of Allergy and Infectious Diseases AWARE funding opportunity announcement.

PI_NAMEs: ELOPRE, LATESHA ELLEN (contact);MATTHEWS, LYNN T

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adherence;Age;AIDS prevention;Alabama;Algorithms;Area;Awareness;Behavioral;Black American;black men who have sex with men;black women;Blood;Camellia sinensis;Caring;Chlamydia;cis-female;cohort;Collaborations;Color;Communities;community advisory board;community engaged research;community partners;County;Data;Data Sources;Deep South;design;Development;Diagnosis;digital;digital platform;Disparity;Dryness;Elements;Eligibility Determination;Enrollment;Epidemic;epidemiologic data;Epidemiology;evidence base;Evidence based intervention;experience;Exposure to;Flowers;Funding;Funding Opportunities;Future;Geography;Goals;Gonorrhea;high risk;High Risk Woman;Hispanic Americans;Hispanic Women;HIV;HIV diagnosis;HIV Infections;HIV risk;Home;home test;Human immunodeficiency virus test;improved;Incidence;Individual;Inequity;Infection;innovation;Institutionalization;Interview;Longitudinal Studies;Mediator;Medical Records;member;Methodology;Mobile Health Application;Monitor;multidisciplinary;Names;National Institute of Allergy and Infectious Disease;North Carolina;novel;Outcome;Outcome Study;Patient Self-Report;Persons;Population;population based;Poverty;pre-exposure prophylaxis;Prevention;prevention service;primary outcome;Process;programs;Public Health;racism;Recording of previous events;recruit;Research;Research Personnel;Research Proposals;Risk;Rural;Sampling;Sexual Health;Sexually Transmitted Diseases;social;social disparities;Spottings;Surveys;Syphilis;Syphilis Serodiagnosis;System;Techniques;Testing;therapy development;tool;transgender women;trend;United States;Universities;uptake;usability;White Women;Woman;women of color;Women's cohort;women's prevention

PROJECT_TITLE: CAMELLIA Cohort: A longitudinal study to understand sexual health and prevention among women in Alabama


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Disruptive behavior disorders affect over 113 million children worldwide—making it a public health concern— whereby approximately 50% of children with autism spectrum disorder (ASD) have co-occurring disruptive behavior that leads to greater impairment and long-term, intensive clinical interventions; however, no study has examined brain biomarkers of disruptive behavior in children with and without ASD. The proposed study will be the first to leverage connectomics, large-scale open science imaging data, and predictive modeling to investigate novel, transdiagnostic biomarkers of disruptive behavior disorders in children with and without ASD. Large multisite neuroimaging data affords unprecedented opportunities to close the gap between basic and translational neuroscience, and to establish biomarkers that could advance development of new, targeted interventions to optimize clinical outcomes.

PI_NAMEs: IBRAHIM, KARIM  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 12 year old;Achievement;Adolescence;Adolescent;adolescent with autism spectrum disorder;Adult;Advanced Development;Affect;Aggressive behavior;Amygdaloid structure;Anger;antisocial behavior;Area;autism spectrum disorder;autistic children;Behavior;Behavior Disorders;Big Data Methods;Biological Markers;biomarker development;Biometry;biotypes;boys;Brain;brain based;Buffers;callous unemotional trait;Child;Childhood;Clinical;cognitive control;cognitive development;cognitive reappraisal;cognitive task;Computer Models;connectome;Data;data modeling;Data Set;Development;Diagnosis;Diagnostic;diagnostic biomarker;Dimensions;Disease;disorder control;disorder subtype;Disruptive Behavior Disorder;Dorsal;DSM-V;emotion regulation;Emotions;Ensure;Environment;Exhibits;Functional disorder;Functional Magnetic Resonance Imaging;Generations;girls;Goals;gray matter;Image;imaging biomarker;Impairment;Individual Differences;interest;Intervention;large-scale imaging data;Link;Machine Learning;Magnetic Resonance Imaging;Mental disorders;Mentorship;Modality;Modeling;multidisciplinary;Multimodal Imaging;National Institute of Mental Health;Neurobiology;neuroimaging;Neurosciences;non-compliance;novel;open data;Outcome;predictive modeling;Prefrontal Cortex;Problem behavior;Psychology;Psychopathology;Public Health;recruit;Research;Research Design;Research Domain Criteria;Research Personnel;Research Priority;Rest;Risk;Sampling;Services;Severities;sex;Sex Differences;Site;Structure;Subgroup;Substance abuse problem;Surface;Symptoms;Testing;Thick;Training;translational neuroscience;translational potential;Work;Youth

PROJECT_TITLE: Multimodal imaging biomarkers of cognitive control network deficits in youths with disruptive behavior

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Kidney Disease;Lupus;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: HOUSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: Despite being the gold standard, histological diagnosis of lupus nephritis is imprecise, and marked by significant inter-pathologist discordance in readings. We propose to leverage the power of computer vision and deep learning to build a classifier that rivals the best-trained renal pathologists in making a histological diagnosis of lupus nephritis. Reliable and reproducible classification of LN could dramatically improve patient management and long-term renal and patient survival.

PI_NAMEs: MOHAN, CHANDRA  (contact);NGUYEN, HIEN VAN

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: accurate diagnosis;Adult;Algorithms;Automobile Driving;Cells;Child;Chronic;Classification;Computer Vision Systems;convolutional neural network;deep learning;Diagnosis;diagnosis standard;Diagnostic;diagnostic criteria;Educational process of instructing;End stage renal failure;falls;Feedback;Histologic;Human;Image;improved;indexing;innovation;Kidney;kidney biopsy;Lupus;Lupus Erythematosus;Lupus Nephritis;Machine Learning;Nephritis;neural network;novel;Outcome;Outcome Study;Pathologist;Pathology;Patients;Performance;Phenotype;predict clinical outcome;Prediction of Response to Therapy;Reading;Reporting;Reproducibility;Retrieval;Structure;Systemic Lupus Erythematosus;Testing;time interval;Tissues;tool;Training;treatment response;Uncertainty;user-friendly;web portal

PROJECT_TITLE: Objective Classification of Lupus Nephritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-W(05)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Physical Activity;Physical Rehabilitation;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Transplantation

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

PHR: In the United States, nearly 150,000 persons, many who identify as Black, Hispanic, or Asian, are hoping for a kidney transplant. Yet as they wait--sometimes more than ten years--many deteriorate physically, worsening their chances for a successful transplant. This study will evaluate if an online exercise program supervised by an instructor can reverse this deterioration, ultimately sustaining the hope for a future without kidney disease.

PI_NAMEs: LIU, CHRISTINE KEE (contact)

PROJECT_TERMS: Accountability;acute care;Adherence;Adoption;arm;Asian;Beck depression inventory;Black Populations;Black race;Caring;Climacteric;Clinic;coping;cost;depressive symptoms;Deterioration;Dialysis procedure;Education;Elements;Event;Excision;Exercise;exercise intervention;exercise program;Fatigue;functional improvement;Future;Goals;Health behavior change;Health education;Healthcare;Hispanic;Home;improved;Individual;innovation;instructor;Intervention;Interview;Kidney Diseases;Kidney Failure;Kidney Transplantation;Knowledge;knowledge translation;Lead;Locales;Measures;meetings;Methods;Motivation;Muscle;Muscular Atrophy;Nephrology;novel;Operative Surgical Procedures;Organ;Outcome;Participant;patient oriented;Patients;Persons;Phase;Physical Function;post-transplant;prevent;primary endpoint;Procedures;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;Readiness;reduce symptoms;Schedule;Science;Severities;Suggestion;Supervision;Testing;therapy design;Time;transplant centers;Transplantation;Travel;United States;uptake;virtual;virtual delivery;virtual healthcare;Vision;Wait Time;Waiting Lists;Walking

PROJECT_TITLE: Virtually Supervised Exercise for Kidney Transplant Candidates

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Genetics;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: FULLERTON

ORG_DEPT: BIOLOGY

ORG_NAME: CALIFORNIA STATE UNIVERSITY FULLERTON

PHR: PROJECT NARRATIVE This research will provide insight into mechanisms used by alpha-proteobacterial pathogens such as Brucella and Bartonella to infect and invade human cells, leading to improved infectious disease prevention and treatment. In addition, this project will provide rigorous research training to prepare students from underrepresented groups for biomedical research careers, increasing diversity in the biomedical research workforce.

PI_NAMEs: CHEN, ESTHER J (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Affect;Alphaproteobacteria;Bacteria;Bartonella;Bartonella henselae;Binding;Biomedical Research;Brucella;Brucella abortus;Candidate Disease Gene;career;Catalogs;cell envelope;cell type;Cells;ChIP-on-chip;Chiroptera;chromatin immunoprecipitation;Communicable Diseases;Consensus Sequence;Critical Pathways;Data Set;Defect;disorder prevention;Eukaryotic Cell;Exhibits;Gene Expression;Gene Expression Profiling;Genes;genetic approach;Genetic Transcription;genome-wide;genome-wide analysis;Genomic Segment;host-microbe interactions;Human;human disease;human pathogen;improved;Infection;insight;Invaded;Knock-out;Membrane Proteins;Modeling;Molecular;Molecular Genetics;Motility;mutant;Mutation;Nutrient;Outcome;overexpression;pathogen;Pathogenicity;Pathway interactions;Peptides;Phenotype;Phosphorylation;Physiology;plant defensin proteins;Plants;posttranscriptional;Prevention;Proteins;Quantitative Reverse Transcriptase PCR;Regulation;Regulator Genes;Regulatory Pathway;Regulon;Research;Research Training;response;Role;Signal Pathway;Signal Transduction;Sinorhizobium;Sinorhizobium meliloti;Small RNA;Students;symbiont;Symbiosis;Transcriptional Activation;undergraduate student;Underrepresented Populations;Underrepresented Students

PROJECT_TITLE: Regulation of the Sinorhizobium meliloti ExoS/ChvI signaling pathway critical for host infection


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Narrative: This proposed research will explore the structure and function of a new feature we recently discovered in the PDL, the dense collar. We hypothesize this unique structure controls tooth stability and therefore we will establish a thorough understanding of the structure and function in health as well as in compromised state such as in periodontitis and orthodontic tooth movement. Identifying a specific region within the PDL that is directly linked to tooth stability will generate a paradigm shift in regenerative therapies for periodontitis as well as new approaches to generate orthodontic tooth movement.

PI_NAMEs: NAVEH, GILI RINA (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: 3-Dimensional;Address;Affect;Aging;alveolar bone;Apical;Area;base;Blood Vessels;bone;Bone structure;Clinical;Coin;Collagen;Collagen Type VI;Complex;crosslink;Crosslinker;Cytology;Cytometry;density;Dental;Devices;dosage;Extracellular Matrix;Fiber;Food;Frequencies;functional restoration;Generations;Health;Impairment;In Situ;in vivo Model;Injury;interdisciplinary approach;Intervention;Link;Location;Mass Spectrum Analysis;Mastication;Measures;mechanical properties;Methodology;Methods;microCT;Modeling;mouse model;Movement;novel;novel strategies;Orthodontic;Orthodontics;Outcome;Pathology;Patients;Periodontal Diseases;Periodontal Ligament;Periodontic specialty;Periodontitis;Predisposition;preference;Process;Proteomics;Raman Spectrum Analysis;regenerative therapy;Research;restoration;Riboflavin;Role;sample collection;Sampling;second harmonic;soft tissue;Structure;Testing;Tissue imaging;Tissues;Tooth Mobility;Tooth Movement;Tooth Socket;Tooth structure;Translating;Trauma;Work

PROJECT_TITLE: Non uniformity in the PDL: structure and function of the dense collar

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ORG_CITY: RENTON

ORG_NAME: PROVIDENCE HEALTH & SERVICES - OREGON

ORG_STATE: WA

PHR: This K22 award will allow me to build my own research platform to further characterize the critical signaling pathways and target genes in sarcoma development and metastasis using these unique in vivo sarcoma models. In Specific Aim 1, we will dissect the mechanism by which the Hippo pathways and their effectors Yap1/Taz drive sarcomas through the mutation of Fat1. In addition, we will use my novel in vivo sarcoma models to test and optimize the best combination treatment strategies that suppress sarcoma tumor growth. In Specific Aim 2, we will determine the mechanisms by which lncRNA Neat1 drives sarcoma metastasis. My preliminary results suggest that RNA splicing regulating genes, such as Khsrp, interact with Neat1 and promote sarcoma metastasis. We will use my unique in vivo sarcoma models to dissect the mechanisms governing sarcoma metastasis and the implications of these genes for targeted therapies in treating metastatic sarcoma patients. In conclusion, completion of this proposal will determine the functional consequences of expression of the coding gene Fat1 and the non-coding gene Neat1 in sarcoma development and metastasis and provide novel candidate pathways and genes for designing effective targeted therapies to improve outcomes for sarcoma patients.

PI_NAMEs: HUANG, JIANGUO  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Adult;Biology;Cells;chemotherapy;Clinical;Code;Combined Modality Therapy;Complex;CRISPR/Cas technology;Data;design;Development;Diagnosis;Distant;FAT gene;Foundations;Funding Agency;Gene Expression Regulation;gene-targeted therapy;Genes;Genetic;Genetic Screening;Genetically Engineered Mouse;genome-wide;Genomics;Goals;Grant;High-Throughput RNA Sequencing;Human;human data;Immunohistochemistry;improved;improved outcome;In Vitro;in vivo;in vivo Model;inhibitor;insight;K22 Award;Knock-out;Knowledge;Lung;Malignant Fibrous Histiocytoma;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mesenchymal Cell Neoplasm;Metastatic Neoplasm to the Lung;Methods;Modeling;Modification;mouse model;Mus;Muscle;Mutate;Mutation;Neoplasm Metastasis;novel;novel therapeutic intervention;Oncogenes;Oncogenic;Organ;overexpression;Pathway interactions;Patients;pharmacologic;Play;Population;preclinical trial;Prognosis;programs;Protein Splicing;Proteins;Research;Resistance;RNA;RNA Splicing;Role;Sarcoma;Signal Pathway;Soft tissue sarcoma;Spliced Genes;Survival Rate;targeted treatment;Testing;Therapeutic;therapeutically effective;Tissue Microarray;transcriptome sequencing;Translating;treatment strategy;tumor;tumor growth;Tumor Suppressor Proteins;Untranslated RNA;Up-Regulation;Wild Type Mouse

PROJECT_TITLE: DISSECTING THE ROLES OF FAT1 AND NEAT1 IN SOFT TISSUE SARCOMA DEVELOPMENT AND METASTASIS USING NOVEL IN VIVO SARCOMA MODELS

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI(B)-I]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Nutrition

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE There is a critical need to understand the effects of ketone bodies on older adults. Ketogenic interventions such as fasting and ketogenic diet are increasingly popular but with limited data, and ketone bodies hold promise as a geroscience-based intervention that targets multiple mechanisms of aging to help treat complex, multifactorial, aging conditions such as frailty. This collaborative project will carry out the first clinical trial of a ketone ester compound in frailty, in order to generate the first robust safety data for this class of compounds in older adults, test if it improves physical function, and carry out detailed biological studies on hypothesized mechanisms in muscle and the immune system. These results will create the foundation for applying ketone body-based therapeutics to frailty and other geriatric conditions that affect the health and independence of older adults.

PI_NAMEs: BARTLEY, JENNA ;NEWMAN, JOHN C (contact);VOLEK, JEFF S

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: actigraphy;Adult;Adverse event;Affect;age related;age-related disease;Aging;aging biomarker;aging mechanism;aging related;Atrophic;Attenuated;beta-Hydroxybutyrate;Biological;Biological Aging;Biological Markers;Biology;Biopsy;Blood;Brain;Calories;Catabolism;Chronic;Clinical;clinical application;Clinical Research;Clinical Trials;cognitive function;cognitive testing;Complex;Data;dietary;dietary restriction;disability;Double-Blind Method;Drug Kinetics;Elderly;Elements;Esters;Fasting;Fatty acid glycerol esters;Foundations;Frail Elderly;frailty;functional decline;Functional disorder;Gait speed;Geriatrics;Geroscience;Goals;Health;healthspan;Heart;Heart failure;heart function;human data;immune function;Immune system;Immune System Diseases;Immunity;Immunophenotyping;immunosenescence;improved;improved outcome;Inflammation;Inflammatory;Institution;instrument;interest;Intervention;ketogenic diet;ketogentic;Ketone Bodies;Ketones;Leg;Link;Lipids;Liver;Measures;Metabolic;Metabolism;Methods;Mitochondria;Modeling;Molecular;multidisciplinary;Mus;Muscle;Muscle Fatigue;muscle metabolism;muscle strength;Muscular Atrophy;novel therapeutics;Nutritional;Ohio;older adult;Oral;Organ;Outcome;pharmacologic;Phase;Physical Function;Physiological;Placebo Control;Placebos;Population;pre-clinical;Pre-Clinical Model;primary outcome;Production;prospective;Quality of life;Randomized;reduced muscle strength;Role;Safety;Scheme;secondary outcome;Signal Transduction;Site;Skeletal Muscle;small molecule;Specialist;standard measure;stressor;Symptoms;Syndrome;System;T-Lymphocyte;Taste Perception;Testing;Therapeutic;Time;Tissues;Translating;Treatment Efficacy;trial enrollment;Universities;wearable device;Wild Type Mouse;young adult

PROJECT_TITLE: TAKEOFF: Targeting Aging with Ketone Ester in Older adults for Function in Frailty


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Patient Safety;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Rates of contralateral prophylactic mastectomy (CPM) have been increasing in the United States among young women with breast cancer. The proposed pragmatic study will evaluate the effectiveness of CONSYDER, a decision support tool for young women making breast cancer surgical decisions, in improving decision quality, thereby potentially reducing CPM, while also evaluating CONSYDER’s implementation across 4 different health systems. We expect findings to not only demonstrate the effectiveness of this intervention but also to inform the optimal delivery of CONSYDER, enabling broader dissemination of this intervention in the future.

PI_NAMEs: GREENUP, RACHEL ADAMS;ROSENBERG, SHOSHANA M (contact)

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TERMS: Adjuvant Therapy;Adoption;Affect;Age;American;Anxiety;Benefits and Risks;Bilateral;Body Image;Breast;breast cancer diagnosis;Breast Cancer Patient;Breast Cancer Risk Factor;Breast Feeding;breast lumpectomy;Cancer Center;cancer surgery;Caring;Clinical;clinical practice;Communication;Complex;Conflict (Psychology);Consolidated Framework for Implementation Research;Consult;Contralateral;cost;Dana-Farber Cancer Institute;Data;Decision Aid;Decision Making;design;Diagnosis;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation design;Fertility;financial toxicity;Future;Goals;Guidelines;Health system;Healthcare Systems;implementation barriers;implementation evaluation;implementation intervention;implementation outcomes;improved;innovation;Intervention;Interview;Knowledge;Life;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Mastectomy;Medicine;Methods;Mind;Multicenter Trials;novel;Online Systems;Operative Surgical Procedures;Outcome;patient oriented;Patient Outcomes Assessments;Patients;peace;Penetration;Perception;Perioperative complication;Personal Autonomy;Phase;Pilot Projects;pragmatic study;preference;Procedures;prophylactic mastectomy;Provider;psychosocial;Quality of life;Radiation;Randomized;Recommendation;Recurrence;Regrets;Reporting;Research;Resources;Risk;risk perception;Self Efficacy;Sexuality;shared decision making;Site;Societies;stress management;Structure;support tools;Supportive care;Surgeon;Surgical complication;surgical risk;surveillance imaging;Surveys;therapy design;tool;treatment as usual;trend;United States;Unnecessary Surgery;uptake;Vulnerable Populations;Woman;women's diagnosis;Work;young adult;young woman

PROJECT_TITLE: Effectiveness and implementation of a decision support tool to improve surgical decision making in young women with breast cancer

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Pediatric

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE Developmental delays and intellectual disabilities are common co-occurring conditions in Down syndrome, which is associated with an extra copy of human chromosome 21, and our proposed research aims to identify new target genes with therapeutic potential for improving cognitive function and thus the quality of life in people afflicted with this chromosomal alteration. These genes will be identified through the use of phenotype-based tests in mouse models tailor-made to facilitate genetic dissection of Down syndrome, and these models will be developed with the aid of CRISPR genome engineering technology. We will also test whether the characteristic features of Down syndrome are impacted by the gene-dosage-independent effects of trisomy 21, such as through alterations in the nuclear architecture, which could help to transform the current paradigm of understanding for Down syndrome-associated cognitive deficits.

PI_NAMEs: YU, EUGENE  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: 3-Dimensional;Affect;Animals;Architecture;Candidate Disease Gene;Cells;Cerebral cortex;Characteristics;Chromosomal Rearrangement;Chromosome 16;Chromosome 21;Chromosome abnormality;Chromosomes;Clinical;clinical phenotype;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cognitive ability;Cognitive deficits;cognitive enhancement;cognitive function;Consensus;Data;Development;Developmental Delay Disorders;Dissection;dosage;Down's Syndrome;Edward's syndrome;effective therapy;Engineering;Exhibits;gene discovery;Gene Dosage;Gene Expression;Generations;Genes;Genetic;genetic analysis;Genome;Genome engineering;Genomic Segment;Genotype;Goals;Human;Human Chromosomes;IFNAR1 gene;improved;Incidence;Individual;inhibitor;innovation;Intellectual functioning disability;Interferon Receptor;Investments;Live Birth;Maps;Mediating;Medical;Modeling;Molecular;mouse model;mouse Ts65Dn;Mus;mutant;Mutant Strains Mice;Nervous System;new therapeutic target;Newborn Infant;novel;Nuclear;Orthologous Gene;Outcome;Patau's syndrome;Penetrance;Persons;Phenotype;Play;Process;Quality of life;Reporting;Research;Role;segregation;success;SYNJ1 gene;Technology;Testing;Therapeutic;therapeutic target;Trisomy;United States

PROJECT_TITLE: Generation and analysis of new mouse models to determine novel therapeutic targets for Down syndrome-associated cognitive deficits

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-A(90)S]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

PHR: PROJECT NARRATIVE In this project, we propose the Multinational Partnership to Prevent HPV-Associated Cancer in People Living with HIV: Brazil, Mexico, Puerto Rico (PHAC-BMPR) that will bring together experienced research sites and world-renowned HPV and HIV researchers to build on established collaborations to conduct clinical trials on prevention of HPV-associated cancers among people living with HIV. This will provide an invaluable opportunity for newer investigators from Latin America/Caribbean (LAC) to participate in and learn from high- quality research. We are performing clinical trials that will help reduce the burden of two HPV-associated cancers in LAC: HPV-associated oropharyngeal cancer and cervical cancer.

PI_NAMEs: ELLSWORTH, GRANT B. (contact);GIULIANO, ANNA R.;VILLA, LUISA LINA;WILKIN, TIMOTHY J.

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Address;Brazil;cancer prevention;Caribbean region;Cervical;cervical cancer prevention;Cervical Cancer Screening;Clinical;Clinical Trials;Collaborations;Conduct Clinical Trials;Country;design;Disease;DNA Methylation;effective intervention;experience;Faculty;Future;Future Generations;Gender;Goals;high risk population;HIV;HIV/AIDS;HPV oropharyngeal cancer;HPV screening;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;improved;Individual;innovation;Institution;Intervention;Investigation;Knowledge;Latin America;Learning;Licensure;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;men;Mentors;Mentorship;Methods;Methylation;Mexico;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;novel;Peer Review;Persons;policy recommendation;Positioning Attribute;prevent;Prevention;preventive intervention;programs;Prospective, cohort study;Publications;Puerto Rico;Reproducibility;Research;Research Infrastructure;Research Personnel;Research Priority;screening program;Site;Testing;therapeutic vaccine;Training;Training Programs;Triage;United States National Institutes of Health;Vaccination;vaccine trial;Woman

PROJECT_TITLE: Partnership for Prevention of HPV-Associated Cancers in People Living with HIV: Brazil, Mexico, and Puerto Rico