NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: EDINBURG

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

PHR: Project Narrative: Cancer health disparities impact millions of people across the US and around the globe. Cancer health disparities are not only associated with poor access to health care, co-morbidities, chronic stress, and ancestry, but also correspond to cultural, socio-economic, biological, and environmental factors. Over the next three years, this conference will continue to increase knowledge and bring together clinicians, faculty, researchers, basic scientists, bioinformaticians, geneticists, and bioethicists on a single platform to move the field forward and make progress in reducing US-Mexico border and global cancer health disparities.

PI_NAMEs: CHAUHAN, SUBHASH C. (contact);TSIN, ANDREW T C

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: Academia;Address;Advocate;Affect;Africa;African American;American Association of Cancer Research;anti-cancer research;Area;Asia;Asian Americans;Award;Awareness;Basic Science;behavioral health;bilingualism;Bioethics Consultants;Biological Factors;Biomedical Research;biomedical scientist;Border Community;Canada;cancer health disparity;Chronic stress;Cities;Clinic;Clinical;Clinical Sciences;Collaborations;Communities;community based participatory research;community engagement;Community Health;Community Health Aides;community intervention;community organizations;Community Outreach;Community Services;comorbidity;continuing medical education;Country;County;design;Developing Countries;Diabetes Mellitus;digital;Disparity population;Education;education research;Environmental Risk Factor;Etiology;Europe;Event;Faculty;Fostering;Future;global health;Goals;Grant;Health;health care availability;health care disparity;health care service utilization;Health Disparities Research;health disparity;health organization;Health Professional;Health Services;Healthcare;Hispanic;Hispanic Populations;Hispanic-serving Institution;Hybrids;improved;innovation;Institution;International;intervention program;Knowledge;Latin America;Latino;Life Style;Location;Malignant Neoplasms;Medical Research;medical schools;Medical Students;meetings;Methods;Mexico;Minority Groups;minority health;minority health disparity;Mission;multimodality;National Institute on Minority Health and Health Disparities;novel strategies;Obesity;Outcome;outcome disparities;outreach;Patient-Centered Care;Personal Satisfaction;Persons;Population;Population Heterogeneity;Positioning Attribute;posters;Precision Health;Process;programs;Research;research facility;Research Personnel;research study;Research Support;Scientific Advances and Accomplishments;Scientist;Series;Side;Socioeconomic Factors;South Texas;Spanish;Students;symposium;Texas;Translations;Travel;underserved minority;Underserved Population;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: International Conference on Cancer Health Disparities


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This proposed training program is designed to provide intensive mentored research training for physicians who are in clinical residencies in Dermatology, Medicine, Neurology, Pathology, and Pediatrics, along with exposure to didactic and scientific enrichment activities, and career development. Residents will be able to fulfill their requirements for specialty board eligibility.

PI_NAMEs: YOKOYAMA, WAYNE M. (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Address;Advisory Committees;Anesthesiology;Area;Award;career;career development;Childhood;Clinical;Clinical and Translational Science Awards;Clinical Medicine;Clinical Research;Clinical Sciences;clinical training;cohort;Communicable Diseases;Competence;Dedications;Dermatology;design;Development Plans;Discipline of obstetrics;Disease;Doctor of Philosophy;doctoral student;Eligibility Determination;Ensure;Environment;Evaluation;Exposure to;Fellowship;follower of religion Jewish;Funding;Graduate Degree;Gynecology;Hospitals;Immune;Immune System Diseases;Immunology;Individual;insight;Institution;matriculation;Medical;medical schools;Medical Students;Medicine;Mentors;National Institute of Allergy and Infectious Disease;Neurology;novel therapeutics;Pathology;Pediatric Hospitals;Pediatrics;physician-scientist training program;Physicians;programs;Radiation Oncology;Research;research faculty;Research Personnel;Research Training;Residencies;Scientist;Sister;Specialty Boards;success;Time;Training;training opportunity;Training Programs;Translational Research;United States National Institutes of Health;Universities;Washington;Woman

PROJECT_TITLE: Infectious Disease/Immunology Stimulating Access to Research in Residency (ID/IMM StARR) Program at Washington University


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Heart Disease;Obesity;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Obesity is associated with increased risk of heart disease due, in part, to chronic inflammation arising from adipose tissue. There are no current targeted therapies to prevent or reverse the inflammation of obesity, and a better understanding of these inflammatory pathways in adipose tissue is key to future therapeutic interventions. This project will determine the anti-inflammatory potential of the diabetes medication empagliflozin, as well as the contribution of adipose tissue inflammation to heart disease in a randomized controlled trial of obese patients.

PI_NAMEs: MASHAYEKHI, MONA  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Address;Adipose tissue;Animals;Anti-Inflammatory Agents;Antigen-Antibody Complex;Antiinflammatory Effect;Aorta;bariatric surgery;Biology;Blood;Blood Vessels;Body Weight decreased;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career;Cell Adhesion Molecules;Cell Communication;Cells;Chronic;circulating biomarkers;Clinical Research;Clinical Trials;Coculture Techniques;cohort;Confocal Microscopy;Data;design;Development;Diabetes Mellitus;Double-blind trial;Endothelial Cells;endothelial dysfunction;Endothelium;Enrollment;Environment;Event;experience;Flow Cytometry;Future;Glucose;Goals;heart disease risk;Heart Diseases;Human;Hypoglycemic Agents;Immune;immune function;Immunology;improved;In Vitro;Inflammasome;Inflammation;Inflammatory;inflammatory marker;inhibitor;Institution;Intercellular adhesion molecule 1;interest;Interleukin-6;Intervention;Knowledge;Lead;Link;Macrophage;Measures;Mediating;Mentors;Microscopy;Molecular;multidisciplinary;Nitric Oxide;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;obese patients;obese person;Obesity;Obesity associated cardiovascular disease;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;Physicians;Placebos;Population;Prediabetes syndrome;Prevalence;prevent;Production;programs;Randomized;randomized trial;Randomized, Controlled Trials;Regulatory T-Lymphocyte;Research;Research Design;Residual state;response;Risk;Sampling;Scientist;sequencing platform;skills;Sodium;standard of care;subcutaneous;Suction Lipectomy;symporter;systemic inflammatory response;T-Lymphocyte;targeted treatment;Testing;Therapeutic Intervention;Transcript;transcriptome sequencing;Translating;translational research program;translational scientist;Vascular Diseases;Venous;Visceral

PROJECT_TITLE: The Effect of SGLT2 Inhibition on Adipose Tissue Inflammation and Endothelial Function

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Data Science;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Networking and Information Technology R&D (NITRD);Rare Diseases;Tuberculosis

PHR: PROJECT NARRATIVE Global observational HIV research is challenged by the significant effort required to collect and harmonize profoundly different data from HIV care and treatment sites around the world. The Harmonist project proposes to develop and share methods and tools for standardizing and coordinating multi-site research collaborations, including standards-enabled tools for secure data exchange, data quality checking, and scientific project and portfolio management. The International epidemiology Databases to Evaluate AIDS (IeDEA) and Regional Prospective Observational Research for Tuberculosis (RePORT) International consortia are participating in the development, testing, and evaluation of this research resource.

PI_NAMEs: DUDA, STEPHANY NORAH (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Academic Medical Centers;Acceleration;Acquired Immunodeficiency Syndrome;Address;Area;base;Caring;Clinical Research;co-infection;cohort;Cohort Studies;Collaborations;Communicable Diseases;Communities;comorbidity;Computer software;Country;Data;Data Collection;data exchange;data framework;data harmonization;data management;data modeling;data pipeline;data quality;Data Set;data sharing;data standards;Databases;Dedications;design;Development;Disease;distributed data;electronic data;Ensure;Epidemic;Epidemiology;epidemiology study;Evaluation Research;Evolution;Face;Feedback;Funding;Future;Goals;Grant;Heterogeneity;HIV;HIV/TB;improved;Incidence;Informatics;Infrastructure;innovation;Institution;International;Measures;Medicine;Mentors;Mentorship;Methodology;Methods;Monitor;National Institute of Allergy and Infectious Disease;Observation in research;Observational Study;open source;operation;Participant;Pattern;Persons;Productivity;programs;prospective;Prospective cohort;Prospective Studies;Publications;R24;Regulation;Research;Research Personnel;Research Project Grants;Research Proposals;Research Training;Resource Development;Resources;Role;satisfaction;Secure;Site;Source;Standardization;Strategic Planning;Structure;success;support tools;synergism;Testing;Time;tool;Training;treatment site;Tuberculosis;United States National Institutes of Health;user-friendly;web platform;web-based tool;Work

PROJECT_TITLE: Harmonist: A Scalable Toolkit for Standardizing and Coordinating Data Sharing Across International Research Networks


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Cancer;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative The goal of this work is to define how cellular metabolism supports and regulates the ability of stem cells to undergo successful differentiation. This proposal utilizes the stepwise, directed- differentiation of human embryonic stem cells into pancreatic epithelium as a model to study the metabolism of human development. Results of this work will provide novel approaches to induce differentiation of cell types of interest from pluripotent stem cells by selectively supporting their growth, and improve our ability to produce stem cell-derived human tissues useful for cell therapies and modeling human disease.

PI_NAMEs: DAVIS, JEFFREY CARL (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Ablation;Anabolism;anti-cancer research;Biomass;Birth;cancer cell;Cell Cycle;Cell Differentiation Induction;Cell Differentiation process;Cell Lineage;Cell model;Cell Proliferation;Cell Therapy;cell type;Cells;Consumption;Data;design;Development;Developmental Biology;differentiation in vitro;directed differentiation;Embryo;Embryonic Development;embryonic stem cell;Environment;Enzymes;Epithelium;Equilibrium;experimental study;Fellowship;Fertilization;Fetal Development;gastrulation;Genetic;Glucose;Glutamine;Goals;Growth;Health;Human Development;human disease;human embryonic stem cell;human tissue;implantation;improved;insight;Institution;Insulin-Dependent Diabetes Mellitus;interest;Isotope Labeling;Journals;Kinetics;Laboratories;Malignant Neoplasms;Massachusetts;meetings;member;Metabolic;metabolic abnormality assessment;Metabolic Pathway;metabolic rate;Metabolism;metabolomics;mitochondrial metabolism;Modeling;NADH;Natural regeneration;novel strategies;Nutrient;Oncogenic;Oxidants;Oxidation-Reduction;Oxidative Phosphorylation;Pancreas;Pancreatic Ductal Carcinoma;Pathway interactions;Patients;Peer Review;Pluripotent Stem Cells;Pre-implantation Embryo Development;premature;Process;professor;Publications;Pyruvate;Pyruvate Dehydrogenase Complex;Quality of life;Regulation;research faculty;Role;single-cell RNA sequencing;small molecule inhibitor;Source;Specific qualifier value;stem cell differentiation;stem cell expansion;stem cell fate;stem cell therapy;stem cells;Stress;success;symposium;Technology;tenure track;Testing;tissue stem cells;Tissues;Training;Transcript;Transgenes;Transgenic Organisms;Tumor Expansion;tumor metabolism;Work

PROJECT_TITLE: Metabolic Regulation of Pancreatic Epithelium Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Because patients who receive in-center hemodialysis for the treatment of end-stage kidney disease incur high costs and experience poor health outcomes (e.g. high mortality and frequent hospitalizations), it is important to find ways to improve care delivery. Advances in communications technologies have created numerous opportunities for telemedicine to improve chronic disease management and could help to address existing gaps and inefficiencies in the way that nephrologists deliver care to patients receiving in-center hemodialysis. In a combination of administrative data analyses and in-person interviews, we will exploit rapid increases in the use of telemedicine that have recently occurred in the setting of the COVID-19 pandemic to identify potential effects of telemedicine on healthcare costs, health outcomes, and patient and provider experiences in dialysis care.

PI_NAMEs: ERICKSON, KEVIN  (contact)

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Address;Adoption;Adult;Affect;Area;Attention;Blood Vessels;care delivery;Caring;Chronic Disease;Clinical;Cluster randomized trial;common treatment;Communication;Communities;Complement;cost;COVID-19 outbreak;COVID-19 pandemic;Data Analyses;Databases;design;Dialysis procedure;Disease Management;Dryness;Emergency Situation;End stage renal failure;Ethnic Origin;Evaluation;experience;experimental study;Failure;Fluid overload;Frequencies;Future;Grant;Health;Health Care Costs;health care settings;Health Personnel;Health Policy;Health Services Accessibility;Hemodialysis;high risk;hospital readmission;Hospitalization;Hospitals;Impaired health;Impairment;Improve Access;improved;Interview;Kidney Transplantation;Maintenance;Medicare;Methods;Monitor;mortality;Nephrology;Office Visits;Outcome;Outpatients;pandemic disease;Patients;payment;Perception;Persons;Physicians;Policies;Policy Maker;poor health outcome;Provider;Race;Regulation;Reporting;response;Risk;Role;Schedule;secondary analysis;socioeconomics;State Government;Structure;Supervision;System;Technology;telehealth;Telemedicine;Time;Travel;United States;United States Centers for Medicare and Medicaid Services;uptake;Visit;Vulnerable Populations;waiver;Weight

PROJECT_TITLE: The Effects Of Telemedicine on Health Outcomes, Costs, and Perceptions of Care Delivery in In-Center Hemodialysis

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Effective treatment for those with severe COVID-19 remains poor. We found that enoxaparin (a low molecular weight heparin) augments the ability alpha-1-antitrypsin (AAT), a naturally occurring protein, to inhibit a key enzyme that is required for the COVID-19 virus to enter human cells. Both enoxaparin and AAT: (i) were also found to reduce the burden of the COVID-19 virus in human cells; (ii) are currently being used clinically for other reasons with excellent safety record; and (iii) have other biochemical properties that antagonize many of the dire consequences of COVID-19. We will test the therapeutic efficacy of AAT plus enoxaparin in two human cell types and in mice against the COVID-19 virus. Establishing the efficacy of AAT + enoxaparin combination will provide a foundation for future clinical trials with the goal of employing more effective therapy for veterans and non-veterans with severe COVID-19.

PI_NAMEs: CHAN, EDWARD D (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;Airway Disease;airway epithelium;alpha 1-Antitrypsin;alpha 1-Antitrypsin Deficiency;alveolar epithelium;Alveolus;antagonist;Anti-Inflammatory Agents;Artificial Intelligence;Autologous;Autophagocytosis;Biochemical;Biological;Biological Assay;Blood Vessels;Breeding;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell injury;Cell surface;Cell Survival;cell type;Cells;Clinical;Clinical Trials;COVID-19;COVID-19 burden;COVID-19 impact;COVID-19 pneumonia;cytokine;Cytoprotection;cytotoxicity;Data;Dendritic Cells;effective therapy;efficacious treatment;Endothelial Cells;Endothelium;Enoxaparin;Enzymes;Epithelial Cells;Epithelium;extracellular;Foundations;Future;Goals;Human;immunothrombosis;in vivo;Individual;Infection;Inflammatory;Inflammatory Response;Inflammatory Response Pathway;Infusion procedures;Injury;Intravenous;Knock-out;Left;Low-Molecular-Weight Heparin;Lung;Macrophage;Middle East Respiratory Syndrome Coronavirus;Modeling;molecular modeling;monocyte;mouse model;Mus;neutrophil;novel;Organ;Pathogenicity;Patient-Focused Outcomes;Peptide Hydrolases;Phenotype;Plasma;pre-clinical;Pre-Clinical Model;prevent;Production;Property;Proteins;Safety;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 spike protein;severe COVID-19;Spleen;synergism;Testing;Therapeutic Effect;therapeutic evaluation;Thrombosis;thrombotic;TMPRSS2 gene;Transgenic Mice;Treatment Efficacy;Veterans;Viral Load result;Virus

PROJECT_TITLE: Establishing the Therapeutic Efficacy of Alpha-1-Antitrypsin and Enoxaparin Against COVID-19


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Narrative The Cell and Molecular Biology Training Program is designed to train the next generation of Ph.D. scientists who will become future independent investigators in academia and industry, and leaders of inter-disciplinary cell and molecular biology research to improve human health. The Program is committed to training a diverse group of students with an emphasis on interdisciplinary, collaborative training in cell and molecular biology. The rigorous, quantitative training proposed will prepare Program trainees for a variety of research careers that provide fundamental insights into human health and disease and development of innovative approaches to therapy and disease prevention.

PI_NAMEs: NELSON, DAVID LOREN (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Cellular biology;Molecular Biology;Training Programs

PROJECT_TITLE: Training Program in Cell and Molecular Biology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: This training program will provide physician-scientists with the mentoring and skills needed to embark on successful careers conducting research in infectious diseases of public health importance in the Unites States and worldwide. The training will focus on HIV, malaria, drug- resistant bacteria, tuberculosis and other diseases of global importance.

PI_NAMEs: GULICK, ROY M. (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Communicable Diseases;Research Training

PROJECT_TITLE: Research Training in Infectious Diseases

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Hypertension;Kidney Disease;Prevention

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

PHR: Soluble klotho is a promising biomarker in chronic kidney disease that has positive effects on the heart and kidney although concerns regarding the accuracy of current assays to measure klotho have limited its use in large clinical cohorts. We propose to use an alternative assay, which we have shown to be superior in pilot data, to measure soluble klotho within the CKD sub-cohort of the Systolic Blood Pressure Intervention Trial. We will compare the new assay with the most commonly used commercial assay, examine the relationship of klotho with cardiovascular disease and kidney disease progression and investigate the factors associated with change in klotho concentrations.

PI_NAMEs: DREW, DAVID ALAN (contact);NEYRA, JAVIER A.

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Affect;Albuminuria;arm;Attenuated;Biological Assay;Biological Markers;Biology;Blood;Blood Pressure;blood pressure control;blood pressure intervention;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cause of Death;Cell Maintenance;Cessation of life;Chronic Kidney Failure;Clinical;Clinical Data;Clinical Research;clinical risk;cofactor;cohort;Communities;coronary fibrosis;Data;Development;Disease;Disease Progression;Enzyme-Linked Immunosorbent Assay;Etiology;Event;Exhibits;fibroblast growth factor 23;Fibrosis;Foundations;Functional disorder;Future;Gene Expression;Genes;Glomerular Filtration Rate;Health;Heart;Heart Hypertrophy;high risk;Human;human study;Hypertension;Immunoprecipitation;Impairment;Individual;Injury;Injury to Kidney;Integral Membrane Protein;Intervention;Intervention Trial;Kidney;Kidney Diseases;Knockout Mice;Measurement;Measures;Metabolism;Minerals;Modeling;mortality;novel;Outcome;overexpression;Oxidative Stress;Participant;Pathologic;Patients;Performance;Persons;Pilot Projects;pre-clinical;preclinical study;prevent;Production;Protocols documentation;Randomized;Recovery;renal damage;Renal function;Renal tubule structure;repaired;Reporting;Reproducibility;Research;Risk Factors;risk stratification;Rodent;Rodent Model;Role;Sampling;Serum;Source;Specific qualifier value;Specimen;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Time;Translational Research;trial comparing;trial enrollment;Tubular formation;Urine;Vascular calcification;Western Blotting

PROJECT_TITLE: The Relation of Soluble Klotho with Cardiovascular Disease, Chronic Kidney Disease Progression, and Blood Pressure in the Systolic Blood Pressure Intervention Trial

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Genetics;Human Genome;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE: The proposed renewal application examines the relationship between exposure to adversity, DNA methylation, and risk for internalizing symptoms within a unique and established longitudinal study of children from South Africa. Findings generated from this research will help identify sensitive periods in development, or stages in the lifespan when the effects of exposure to adversity on DNA methylation and subsequent psychopathology are most harmful. The identification of sensitive periods in development will aid in determining mechanisms through which adversity increases psychopathology risk and will help guide the investment of public health resources to when they can have the highest impact on reducing risk for mental disorders.

PI_NAMEs: DUNN, ERIN CATHLEEN (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Adult;Affect;Age;age related;Award;Biological;Biological Markers;Birth;Blood;Blood Banks;Blood specimen;Brain;Candidate Disease Gene;Cell Culture Techniques;Child;Child Health;Child Mental Health;Childhood;childhood adversity;Chronic;cohort;Coin;Cross-Sectional Studies;Data;Development;Disease;DNA Methylation;early childhood;early life adversity;Ensure;Environment;Environmental Risk Factor;Epidemiology;Epigenetic Process;epigenome;ethnic diversity;European ancestry;experience;experimental study;Exposure to;Family;Functional disorder;Gene Expression;Genes;Genetic;Genetic Determinism;Genetic Variation;Genome;genome-wide;Genotype;Health Resources;high dimensionality;high risk;Household;Human;in silico;in vivo;Individual Differences;insight;Intervention;Investments;Life;Life Cycle Stages;life span;lifetime risk;Link;Longitudinal Studies;Measures;Mediating;Mediation;Mediator;Mendelian randomization;Mental Depression;Mental disorders;Mental Health;methylation pattern;Modeling;Modification;Molecular;neuropsychiatric disorder;Outcome;Pattern;Perinatal;population based;Population Heterogeneity;postnatal;prevent;prospective;Psychopathology;Public Health;racial diversity;Records;Regulation;Research;Risk;Risk Factors;Risk Reduction;Role;Sampling;Scientist;Shapes;social;social determinants;social factors;sociodemographic factors;South Africa;Structure;Symptoms;Testing;Time;tool;Umbilical Cord Blood;violence exposure;Work;Youth

PROJECT_TITLE: Childhood adversity, DNA methylation, and psychopathology symptoms: A longitudinal study of sensitive periods and chrono-epigenetics

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Diabetes;Genetics;Human Genome;Immunotherapy;Pediatric

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative Type 1 Diabetes (T1D) is a chronic debilitating autoimmune disorder affecting an estimated 1.6 million Americans with no cure. While B cells are important in the pathogenesis of T1D, little is known regarding which B cells are the pathogenic offenders and how exactly they contribute to disease. The goal of this study is to identify which B cell subset(s) are involved in the pathogenesis of T1D using a novel single cell sequencing platform, we term AVID-seq, to inform our understanding of T1D and aid in development of future therapeutics.

PI_NAMEs: NICHOLAS, CATHERINE A (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Advisory Committees;Affect;Affinity;Age;American;Antibodies;Antibody Affinity;antigen binding;Antigen Presentation;Antigen-Presenting Cells;Antigens;Autoantibodies;Autoantigens;Autoimmune Diseases;autoreactive B cell;B cell therapy;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocyte Subsets;B-Lymphocytes;Bar Codes;Binding;bioinformatics pipeline;Biotin;Biotinylation;Blood;Blood Glucose;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Chemistry;Chronic;Clinical;Collection;comorbidity;cytokine;Data;Data Set;Detection;Development;Development Plans;diabetes pathogenesis;diabetogenic;Disease;Disease Progression;DNA;doctoral student;droplet sequencing;Environment;Exhibits;experimental study;Fluorescence-Activated Cell Sorting;Fostering;Frequencies;Future;Gene Expression;Goals;Growth;Human;Immunoglobulin D;Immunoglobulin G;Immunoglobulin M;improved;Incubated;Individual;innovation;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans;Learning;Ligands;Magnetism;Measurement;Measures;Membrane Proteins;Messenger RNA;Methods;Modeling;Modernization;molecular phenotype;mRNA Expression;nanoparticle;novel;offender;Outcome;Pancreas;Pathogenesis;Pathogenicity;peripheral blood;Peripheral Blood Mononuclear Cell;Phenotype;phenotypic data;pre-doctoral;Production;programs;protein expression;receptor;Recombinant Antibody;Research;rituximab;Role;Sampling;sequencing platform;sex;single cell sequencing;single-cell RNA sequencing;Specificity;Surface Plasmon Resonance;T-Cell Receptor;T-Lymphocyte;Technology;Testing;Tetanus;Therapeutic;Tissue-Specific Gene Expression;Training;transcriptome sequencing

PROJECT_TITLE: Characterizing molecular phenotypes of pancreatic islet reactive B cells in T1D through single cell sequencing


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ALBANY

ORG_NAME: STRATTON VETERANS ADMIN MEDICAL CENTER

PHR: Project Narrative In the Veteran population, peripheral nerve injury is a leading cause of disability within the Military Health System (MHS), with peripheral neuropathy being a primary health concern of Veterans. To treat long-gap nerve injury, donor autografts are isolated from elsewhere in the patient. Autograft isolation leads to donor site morbidity, and some Veterans are unable to donate autografts due to other complications (i.e. diabetes). As alternatives to the autograft, allografts or biomaterial conduits are being developed and used clinically. However, with allografts, extensive decelluarization procedures are required, and biomaterial conduits lack sufficient extracellular matrix (ECM) to promote extension regeneration. Our approach will develop biomaterial conduits releasing mRNA for neurotrophin-3 (NT-3). As a result, we believe the enhanced production of NT-3 by cells at the injury site will lead to extensive regeneration, leading to a new approach to treat neural injury in the Veteran population.

PI_NAMEs: GILBERT, RYAN J. (contact)

PROJECT_TERMS: Allografting;Autologous;Autologous Transplantation;axon growth;axon regeneration;Biocompatible Materials;biodegradable polymer;bioscaffold;cell growth;cell motility;Cells;Chemicals;Chicago;Clinical;Clinical Medicine;Collaborations;comorbidity;Complications of Diabetes Mellitus;Defect;design;Development;Diabetes Mellitus;Diabetic Neuropathies;disability;Disease;Distal;DNA;Drug Delivery Systems;effectiveness evaluation;experimental study;Extracellular Matrix;Fiber;Fostering;Growth Factor;Harvest;Health;Immunosuppression;implantation;improved;in vivo Model;Infiltration;injured;Injury;innovation;Interdisciplinary Study;Investigation;Lesion;Macrophage;Messenger RNA;military health system;Military Personnel;military veteran;Modeling;Morbidity - disease rate;mRNA delivery;Natural regeneration;Nerve;nerve autograft;nerve gap;nerve injury;Nerve Regeneration;nerve repair;Nerve Tissue;neural;Neurites;Neurotrophin 3;novel;novel strategies;Outcome;Patients;performance site;Peripheral;Peripheral nerve injury;peripheral nerve regeneration;peripheral nerve repair;Peripheral Nerves;Peripheral Nervous System Diseases;Pharmaceutical Preparations;poly-L-lactic acid;Polymers;pre-clinical;Pre-Clinical Model;Preparation;Procedures;Process;Production;protein expression;Proteins;prototype;Publications;Rattus;Recovery;Recovery of Function;regenerative;Regenerative response;repaired;Research;Research Institute;response;scaffold;Schwann Cells;sciatic nerve;Science;Shapes;Site;small molecule;Spinal Ganglia;stem cells;sural nerve;Surface;Surgical sutures;Testing;Tissue Donors;Tissue Engineering;Tissues;tool;tumor;United States;Veterans;Work

PROJECT_TITLE: mRNA-containing fibrous conduits for repair of long-gap peripheral nerve injury

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: Effective rehabilitation procedures are still lacking for stroke, the leading cause of long-term motor disability. Transcranial alternating current stimulation (tACS) is a promising noninvasive brain stimulation approach that can promote motor recovery. Understanding the neurophysiological effects after stroke regarding individual variability, dose-response relationship, safety, and tolerability issues can facilitate implementation of tACS in rehabilitation settings. Our proposed studies will determine if tACS, together with upper limb motor rehabilitation, can improve motor function and the role of cerebral blood flow enhancement as a neurophysiological marker, to optimize post-stroke intervention in mature adult mice (male and female, with or without vascular abnormalities).

PI_NAMEs: GALEFFI, FRANCESCA  (contact)

PROJECT_TERMS: Address;Adult;Age;Age Months;angiogenesis;Behavioral;Binding;Biological Markers;Blood Vessels;Brain;Calibration;Cause of Death;Cephalic;cerebrovascular;Cerebrovascular Circulation;Chronic Phase;Clinical Trials;clinically relevant;cognitive enhancement;cognitive function;cognitive performance;cognitive recovery;Collateral Circulation;Common carotid artery;comorbidity;Complication;Contralateral;Data Reporting;density;disabled;Distal;dosage;Dose;Electric Stimulation;experimental study;Female;Frequencies;functional outcomes;gender difference;Genes;Goals;healthy volunteer;hemodynamics;Hour;Human;Impairment;implementation facilitation;improved;individual variation;Infarction;Intervention;Ipsilateral;Ischemic Stroke;Knockout Mice;Ligation;Long term disability;long term recovery;Longitudinal Studies;male;Measures;Mediating;middle age;Middle Cerebral Artery Occlusion;military veteran;Modeling;Monitor;Motor;Motor disability;motor function improvement;motor impairment;motor learning;motor recovery;motor rehabilitation;Mouse Strains;Mus;Nervous System Physiology;neurogenesis;Neurologic;neurological recovery;neuronal circuitry;neuronal excitability;Neuronal Plasticity;Neurons;neurophysiology;neurovascular;noninvasive brain stimulation;old mice;older adult;Outcome;Patients;Performance;Perfusion;Peripheral;Persons;Population;post stroke;prevent;Procedures;Proteins;Protocols documentation;rab GTP-Binding Proteins;Recovery;Recovery of Function;rehabilitation strategy;Rehabilitation therapy;repaired;Reperfusion Therapy;response;Risk Factors;Role;Safety;Side;skills;Stroke;stroke intervention;stroke model;stroke outcome;stroke patient;stroke rehabilitation;Study models;Surrogate Markers;Task Performances;Techniques;thrombolysis;Time;tool;Training;treatment effect;Upper Extremity;vascular abnormality;young adult

PROJECT_TITLE: Transcranial Electrical Stimulation Promotes Cerebral Blood Flow, Enhancing Cognitive and Motor Recovery with Concurrent Rehab Training after Stroke


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This project proposes an artificially intelligent, semi-autonomous planning and robotic approach for lung cancer biopsy leveraging MR guidance. An AI-enabled robot planner identifies the least traumatic and safest biopsy needle approach for a particular patient, and then, a dexterous robot inserts the needle under real-time CT guidance. This automated method will allow patient-specific information to be incorporated into planning for lung biopsies, enabling sensitive anatomies to be avoided, lesions to be reached faster and more accurately, providing significant more effective screening and safety than today’s freehanded approach.

PI_NAMEs: YIP, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: 3-Dimensional;Acute;Address;Air Embolism;Algorithms;Anatomy;Articulation;Artificial Intelligence;Automation;Biopsy;Blood Vessels;Breathing;Cancer Etiology;Cessation of life;Chest;Clinical Research;clinically relevant;Comparative Study;Complication;Computed Tomography Scanners;Conscious;Core Biopsy;cost;Data;Decision Making;design;dexterity;Diagnosis;exhaust;Fatigue;Feedback;Freedom;Goals;Health;Hemorrhage;Hemothorax;high risk;Hour;Human;Image;image guided;imager;Individual;interest;Intervention;ionization;Ionizing radiation;Length;Lesion;Link;low dose computed tomography;Lung;lung cancer screening;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Manuals;Methods;mortality;Motion;Movement;Needle biopsy procedure;Needles;neurovascular;Newly Diagnosed;Obstruction;Outcome;patient population;patient safety;Patients;Performance;Periodicals;Peripheral;Physicians;Pleura;Pleural;Pneumothorax;Population;Population Heterogeneity;Positioning Attribute;Procedures;Prospective Studies;Puncture procedure;Radiation;radiologist;real-time images;Risk;Risk Factors;Robot;robot control;robotic system;Robotics;Safety;Sampling;Scanning;screening;Somatotype;Specific qualifier value;Structure;Survival Rate;Symptoms;System;Time;Tissue Sample;Tissues;Translating;United States;Variant;vector;ventilation;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Automated Planning and Robotic Delivery of Needle Biopsies under CT Image Guidance

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS) is a partnership of Georgetown University, Howard University, MedStar Health Research Institute, the Washington DC Veterans Administration Medical Center, and Oak Ridge National Laboratory. Through this innovative collaboration, GHUCCTS has been a catalyst for developing collaborations between institutions and disciplines, and transforming clinical translational research and training in the greater Washington DC region. We will continue to accelerate the translation of scientific discoveries into improved patient care and public health by supporting projects that address health concerns of our communities in the Washington, DC region and the nation.

PI_NAMEs: GONDRE-LEWIS, MARJORIE C;MELLMAN, THOMAS A;VERBALIS, JOSEPH G (contact)

PROGRAM_OFFICER_NAME: BOUGH, KRISTOPHER J

PROJECT_TERMS: Academia;Acceleration;Achievement;Address;analytical method;career;career development;catalyst;Clinical;clinical center;Clinical Investigator;Clinical Research;Clinical Sciences;clinical translation;Collaborations;Communities;Computing Methodologies;Cultural Backgrounds;Degree program;design;Disabled Persons;Discipline;District of Columbia;Education;Enrollment;Ethnic Origin;Faculty;Funding;Future;Goals;Grant;Health;health determinants;health disparity;Health Professional;Home;improved;Informatics;Infrastructure;innovation;Institution;inter-institutional;interdisciplinary collaboration;Interdisciplinary Study;Laboratories;Leadership;life span;Location;Master of Science;Medical center;member;Mentorship;Minority-Serving Institution;Mission;Modeling;Multi-Institutional Clinical Trial;National Center for Advancing Translational Sciences;new technology;older adult;Patient Care;Persons;Population;Process;programs;Public Health;racial diversity;Research;Research Institute;Research Personnel;research study;Risk;Role;Science;Scientist;Speed;Students;System;TNFSF15 gene;Training;Training and Education;Training Programs;Translational Research;translational scientist;Translations;Underrepresented Populations;Underserved Population;United States Department of Veterans Affairs;Universities;Veterans;Washington


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Gene and cell therapy – including gene therapy for rare or complex disease, genome editing, cell replacement, and tissue engineering – is emerging as the next generation of therapeutics to address unmet medical need, and their investigation is also enabling basic investigation of human development and modeling of human disease. Scientists with interdisciplinary backgrounds in biology and engineering are needed to rapidly advance this field. To address this need, the primary objective of this Biology and Biotechnology of Gene and Cell Therapy (BBGCT) Training Program is to provide a structured, supportive, diverse, and interdisciplinary classroom and research training opportunity in our rapidly emerging and expanding discipline.

PI_NAMEs: HOCKEMEYER, DIRK ;SCHAFFER, DAVID V (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TITLE: Biology and Biotechnology of Cell and Gene Therapy


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Project Narrative The replicative CMG helicase is an enzyme that is required for DNA replication and important for cancer cell growth. The goals of this project are to understand how two proteins involved in cancer, Rb and Myc, directly regulate the human CMG helicase at the biochemical level. Knowledge from this work will not only provide an understanding of how these proteins control the CMG helicase in cancer, but also teach us how the CMG helicase can be inhibited enzymatically to inform drug discovery efforts aimed at targeting the CMG helicase for cancer intervention.

PI_NAMEs: ALEXANDROW, MARK G. (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: ATP Hydrolysis;Binding;Binding Sites;Biochemical;Biological Assay;C-terminal;Cancer Cell Growth;Cancer Intervention;Cell Cycle Progression;Cell Cycle Regulation;Cells;Chromatin;cofactor;Complex Analysis;Development;DNA;DNA biosynthesis;DNA Damage;drug development;drug discovery;Educational process of instructing;Enzymes;Exons;Future;G1/S Transition;Genetic Transcription;Goals;helicase;Human;Human Activities;In Vitro;Inherited;Insecta;Knowledge;Malignant Neoplasms;Measures;Molecular;MYC Box;N-terminal;novel;Oncogenic;Oncoproteins;Pathway interactions;Peptides;Play;Proteins;Recovery;Regulation;Role;S phase;Site;Stress;Techniques;transcription factor;Tumor Suppressor Proteins;tumorigenesis;Work

PROJECT_TITLE: Direct Control of the human CMG Helicase by Myc and Rb

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Heart Disease;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE Chronic psychosocial stress is associated with increased risk for cardiovascular disease (CVD), and exaggerated stress-related cardiovascular reactivity (CVR) has also been linked with elevated CVD risk. The purpose of this study is to examine the feasibility and effectiveness of a smartphone-based mindfulness training program for reducing stress and stress reactivity measures that have been linked with CVD risk in a population selected for vulnerability to stress and CVD, to examine whether the addition of practice prompts that are presented during daily life enhances these effects, and to develop a computer model to assist in identifying the circumstances in which such prompts may be most fruitfully employed. The goal is to produce a scalable mobile health intervention that can be shown to reduce progression of preclinical CVD as part of a subsequent Phase 2 clinical trial.

PI_NAMEs: KAMARCK, THOMAS WILSON (contact);LINDSAY, EMILY

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Acceleration;Acute;acute stress;adaptive intervention;Address;Aftercare;Age;Age Factors;Ambulatory Monitoring;Atherosclerosis;Behavioral;Benchmarking;Biological Markers;Blood Pressure;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cellular Phone;Chronic;Clinical;Clinical Trials;cohort;Computer Models;Conflict (Psychology);Data;Data Correlations;design;Detection;Development;disorder risk;Effectiveness;Enrollment;Environment;Event;Exhibits;Experimental Designs;Exposure to;Goals;Health;Hypertension;Intervention;Laboratories;Life;Life Stress;Link;Literature;Measures;mhealth interventions;middle age;mindfulness;mindfulness intervention;Mindfulness Training;Modeling;mortality;occupational stress;older adult;Outcome;Participant;perceived stress;Phase II Clinical Trials;Physiological;Population;portability;pre-clinical;programs;Psyche structure;Psychosocial Stress;Public Health;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Recurrence;Reporting;Research;response;Risk;Risk Factors;Sampling;satisfaction;side effect;social;Source;Standardization;Stress;stress reactivity;stress reduction;stressor;Testing;Time;tool;Training;Training Programs;treatment as usual;treatment duration;treatment effect;Treatment/Psychosocial Effects;usual care arm;Work

PROJECT_TITLE: Smartphone-based mindfulness intervention for reducing stressrelated CVD risk

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(OA)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative This research investigates how physical or behavioral context can influence our perception of the world around us. Malfunctions of these interactions can lead to maladaptive behaviors exhibited by mental health patients and patients with severe trauma. In particular, the direct integration of context into basic early sensory signals in the brain suggests a deep entanglement that may warrant changes to desensitization strategies for treating post-traumatic stress disorders.

PI_NAMEs: CLELAND, THOMAS A;LINSTER, CHRISTIANE  (contact);SMITH, DAVID M.

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Animals;Anterior;Area;awake;Behavioral;Brain;Collaborations;Cues;Data;Decision Making;desensitization;Electrophysiology (science);Exhibits;experimental study;Fiber;hippocampal pyramidal neuron;Hippocampus;Immediate-Early Genes;interest;Ipsilateral;Label;Learning;maladaptive behavior;Maps;Measurement;Mediating;Mental Health;multimodality;multisensory;neural;neural network;Neurons;neurophysiology;Odors;olfactory bulb;olfactory nuclei;Olfactory Pathways;optogenetics;Patients;Perception;Physiological;piriform cortex;Play;Post-Traumatic Stress Disorders;Price;Publishing;Research;Research Personnel;response;Rodent;Role;Sensory;sensory integration;Series;Signal Transduction;Smell Perception;spatial integration;Stimulus;Structure;System;Testing;Time;tool;Trauma

PROJECT_TITLE: Role of anterior olfactory nucleus for multi-sensory integration in the olfactory system

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_DEPT: GENETICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative - Overall There are now increasing numbers of evidence that bone through the hormones, osteocalcin or lipocalin 2, can be involved in the body reactions to various types of stressors. Moreover, some of the functions that are promoted by osteocalcin decrease with age. This application aims at exploring the relationship between bone and stress response and at using this knowledge to combat manifestations of aging.

PI_NAMEs: KARSENTY, GERARD  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acute;Address;Affect;Age;Aging;Animal Model;Animals;Anti-Inflammatory Agents;Bacterial Infections;Beta Cell;biological adaptation to stress;Biology;blood glucose regulation;bone;Cell Count;Cellular biology;combat;deprivation;Desire for food;diet-induced obesity;Endocrine Glands;Endocrinology;Energy Metabolism;Estrogens;gain of function;Glutamates;Gonadal Steroid Hormones;Hormones;in vivo;Inflammation;Investigation;Knowledge;LCN2 gene;Life;loss of function;member;Menopause;Neurosciences;novel;Osteoblasts;Osteocalcin;prevent;Production;Reaction;Regulation;Research Personnel;response;Role;Sense Organs;sensor;Stress;stressor;Testing;Thermogenesis;Time;Visit;Work

PROJECT_TITLE: Bone as a Sensor of and Responder to Stress During Aging


NIH_SPENDING_CATS: Aging

PROJECT_TERMS: Advisory Committees;Aging;Archives;Authorization documentation;Award;bone;Budgets;central database;Consult;Data;data integrity;data management;Documentation;Ensure;Ethics;Evaluation;experience;Financial Activity;Fostering;Funding;Human Resources;Individual;Institution;Institutional Review Boards;International;Leadership;Maintenance;meetings;Policies;Preparation;Program Evaluation;Program Research Project Grants;programs;Progress Reports;Publications;Radioisotopes;Recombinant DNA;Records;Reporting;Research;Research Activity;Research Personnel;Research Support;Resources;response;Sampling;Schedule;Scientist;sensor;Services;Stress;Supervision;United States National Institutes of Health;Vertebrates;Visit

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Aging;Bioengineering

PI_NAMEs: DUCY, PATRICIA FLORENCE (contact)

PROJECT_TERMS: Aging;Biological;bone;Brain;Bromodeoxyuridine;Cell Count;Cells;cresyl violet;Cryoultramicrotomy;Data;Dehydration;Detection;Equipment;Hematoxylin and Eosin Staining Method;Histologic;histological specimens;Histology;Human Resources;Image;In Situ Nick-End Labeling;long bone;Medical;microCT;Minerals;mouse model;Mus;Osteogenesis;Pancreas;Paraffin;programs;Proliferating;Research Personnel;Scanning;sensor;Skeleton;Specimen;spine bone structure;Stains;Stress;Switzerland;System;Tissues;Tolonium chloride;Trichrome stain method

PROJECT_TITLE: Histology and Histomorphometry Core


NIH_SPENDING_CATS: Clinical Research;Hematology;Infant Mortality;Infectious Diseases;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Sepsis

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Platelets are small blood cells that participate in clot formation to stop bleeding and also in the response to inflammation, although only their clot forming abilities are considered when administering platelet transfusions to premature babies, who often receive platelet transfusions in hopes of decreasing their bleeding risk. Premature babies are a vulnerable population with high morbidity and mortality due to multiple disease processes, and a recent large study found that babies who received more platelet transfusions had a higher mortality and risk of lung disease than babies who were transfused less. In this project I will investigate the effects of platelet transfusions in models of neonatal infection and lung disease and the mechanisms through which platelet transfusions increase neonatal mortality and lung injury, with the hope of improving the outcomes of these most vulnerable patients.

PI_NAMEs: DAVENPORT, PATRICIA ELLEN (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Admission activity;Adult;Advisory Committees;Affect;Award;Awareness;Biology;Birth;Blood;Blood Cells;Blood Platelets;Boston;Bronchopulmonary Dysplasia;career;career development;Cell Communication;Cells;Cessation of life;Chemotactic Factors;Child;Chronic lung disease;Clinical;clinical practice;Clinical Research;clinically relevant;Coagulation Process;Communicable Diseases;Complication;CXCL1 gene;CXCL5 gene;cytokine;Data;Dedications;design;Development;Disease;Endotoxemia;Environment;European;experimental study;Extremely Low Birth Weight Infant;Functional disorder;Funding;Future;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Health;Hematology;Hemorrhage;Hemostatic function;high risk;Host Defense;Hour;Human;Human Biology;Hyperoxia;IL17 gene;Immune;Immune system;Immunology;improved;improved outcome;In Vitro;Incidence;Inflammation;Inflammatory;Inflammatory Response;insight;Interferon Type II;Interleukin-6;Knowledge;Laboratories;Link;Lung;Lung Diseases;lung injury;Macrophage;Manuscripts;Mediating;medical schools;Medicine;meetings;Mentors;Mentorship;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Neonatal;neonatal human;neonatal infection;Neonatal Intensive Care Units;Neonatal lung;neonatal lung disease;neonatal lung injury;neonatal mice;neonatal morbidity;Neonatal Mortality;neonatal sepsis;Neonatal Thrombocytopenia;neonate;Neonatology;neutrophil;Newborn Infant;Observational Study;Organ;Oxygen;Participant;Pathology;Pathway interactions;Patients;Pediatric Hospitals;Phenotype;Physicians;Physiology;Planets;Plasma;Platelet Count measurement;Platelet Transfusion;polymicrobial sepsis;postnatal;premature;Premature Infant;preterm newborn;prevent;primary outcome;Process;Productivity;Publishing;pulmonary function;Pulmonary Inflammation;Randomized;randomized trial;Research;Research Design;Research Personnel;Resources;response;Risk;Role;Scientist;secondary outcome;Sepsis;Severities;statistics;Stimulus;success;Surveys;synergism;systemic inflammatory response;Testing;Thrombocytopenia;Time;Training;training opportunity;Transfusion;transfusion medicine;Umbilical Cord Blood;United States National Institutes of Health;Vulnerable Populations;Writing

PROJECT_TITLE: Effects of Platelet Transfusions on Neonatal Chronic Lung Disease and Sepsis-Induced Mortality


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

PROJECT_TERMS: acute stress;Address;Affect;age related;Aging;Agreement;animal old age;Animals;Anxiety;Appearance;Automobile Driving;Binding;Biological;biological adaptation to stress;Biological Assay;Biology;blood glucose regulation;blood-brain barrier crossing;bone;Bone Marrow Cells;Bone Resorption;Brain region;Brain-Derived Neurotrophic Factor;carboxylate;Catabolism;cell type;Cells;Cellular biology;Circulation;cognitive function;Collaborations;Data;Degenerative Disorder;Dissection;Endocrine;endurance exercise;Energy Metabolism;Enzymes;epidemiology study;Equus caballus;excitatory amino acid transporter 3;Exercise;Exhibits;experimental study;Fatty Acids;Fertility;G-Protein-Coupled Receptors;gain of function;gamma-Aminobutyric Acid;gamma-glutamyl carboxylase;Genetic;Glucose;glucose metabolism;Glutamate Transporter;Glutamates;Goals;GPRC6A gene;healthy aging;Hormones;Human;improved;in vivo;insulin secretion;Intake;juvenile animal;Learning;leydig interstitial cell;Life;Memory;model organism;Molecular;Monkeys;monoamine;Mus;Muscle function;Nature;Neurons;Neurotransmitters;Organ;Osteoblasts;Osteocalcin;Osteocytes;overexpression;Peripheral;Phenotype;Physiological;Physiological Processes;prevent;Rattus;receptor;Regulation;Running;sensor;Severities;Signal Transduction;Specificity;Stress;stressor;Structure of beta Cell of islet;Testing;Testis;Testosterone;Therapeutic;uptake;Wild Type Mouse;Work

PROJECT_TITLE: Regulation of osteocalcin secretion and its therapeutic implication


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE This is a training program to train promising young scientists at the postdoctoral level (post Ph.D.) in molecular, cellular, behavioral and clinical neuropsychopharmacology. Trainees participate in scientific project development, seminars from visiting scientists, a course in neurobiology of addiction, a course in ethical conduct of research, training in rigor and reproducibility, and training in career development for pathways to independence. Established procedures for recruitment to increase diversity in research, evaluation and career development are in place.

PI_NAMEs: ROBERTO, MARISA  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK


NIH_SPENDING_CATS: Aging;Infectious Diseases;Neurosciences

PI_NAMEs: KOUSTENI, STAVROULA  (contact)

PROJECT_TERMS: Acceleration;Acute;Acute-Phase Reaction;Aging;aging population;Agreement;Amino Acids;Anti-Inflammatory Agents;Bacteremia;Bacterial Infections;Blood;bone;Bone Marrow;Bone Tissue;Brain;Cell Wall;Cells;Cellular Structures;Characteristics;Circulation;cytokine;Data;Dendritic Cells;Desire for food;Disease;Endocrine;Endotoxemia;Escherichia coli Infections;Event;Exhibits;Ganglionic Blockers;Glutamate Transporter;Glutamates;Goals;Gram-Negative Bacteria;Hormones;Hour;human old age (65+);Immune;Immune response;Impairment;In Vitro;in vivo;indexing;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innate Immune Response;interest;Kainic Acid Receptors;Lactate Dehydrogenase;LCN2 gene;Life;Lipopolysaccharides;Macrophage;Mediating;Mediation;Metabolic;Modeling;monocyte;mortality;Mus;N-Methyl-D-Aspartate Receptors;Natural Immunity;Neurons;Neuropeptides;neurotransmission;Neurotransmitters;novel;old mice;older adult;Organ;Osteoblasts;Osteocalcin;Phenotype;Play;Predisposition;prevent;Proteins;receptor;response;Role;Sense Organs;sensor;Sepsis;Serum;Signal Pathway;Signal Transduction;Stimulus;Stress;stressor;systemic inflammatory response;Time;Tissues;transmission process;young adult

PROJECT_TITLE: Bone as a regulator and responder to acute inflammation throughout life


NIH_SPENDING_CATS: Clinical Research;Genetics;Lung;Organ Transplantation;Pulmonary Fibrosis;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Although telomere regions at the ends of human chromosomes normally shorten with age, accelerated shortening can lead to diseases like idiopathic pulmonary fibrosis (IPF) that may necessitate lung transplantation. This proposal tests the innovative hypothesis that accelerated telomere shortening may also cause loss of function in the transplanted lung. This novel paradigm could lead to novel diagnostics and interventions to improve survival following lung transplantation.

PI_NAMEs: GREENLAND, JOHN  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acceleration;Affect;Age;Allografting;alveolar epithelium;Award;Biopsy;Biopsy Specimen;Bronchiolitis;Cell Aging;Cells;Cessation of life;Characteristics;Chromosomes;Chronic;Clinical;Closure by clamp;cohort;Cohort Studies;Cox Models;Cox Proportional Hazards Models;Data;Development;Disease;Donor person;Donor Selection;Enrollment;Epithelial Cells;epithelial stem cell;Epithelium;Failure;fibrotic lung disease;Fluorescent in Situ Hybridization;Functional disorder;Genetic Crosses;Genetic Induction;Genetic Risk;genetic variant;Genetic Variation;Genotype;Germ Lines;graft dysfunction;Hand;Hilar;Human;Human Chromosomes;idiopathic pulmonary fibrosis;IL2RG gene;Immune;Immune response;Immunofluorescence Immunologic;Immunosuppression;Impairment;improved;improved outcome;Inflammation;Injury;innovation;Intervention;Investigation;Isogenic transplantation;Label;Length;Life;Link;Longitudinal cohort;loss of function;Lung;lung allograft;Lung Diseases;lung injury;Lung Transplantation;Lymphocyte;Measures;Mediating;Molecular;mouse model;Mus;novel;novel diagnostics;Nucleoproteins;Organ;Outcome;Pathogenesis;Pathologic;Pathology;Patient-Focused Outcomes;Patients;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;post-transplant;Predisposition;Proliferating;prospective;Pulmonary Surfactant-Associated Protein C;Rehabilitation therapy;Reperfusion Injury;response;Risk Assessment;Risk Factors;Role;Sampling;Secondary to;Solid;stem cells;telomere;Telomere Shortening;Testing;Therapeutic Intervention;Time;Tissues;Transplant Recipients;Transplantation

PROJECT_TITLE: Telomere Dysfunction as a cause of Chronic Lung Allograft Dysfunction

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


PROJECT_TERMS: Adult;Affect;Age;age effect;age related;age related decline;Aging;aging process;Beta Cell;Biology;Blood;Blood Glucose;blood glucose regulation;bone;Bone Resorption;capsule;carboxylate;carboxylation;Cell Physiology;Cell Proliferation;Cell Survival;Cell Transplantation;Cells;Cellular biology;Cellular Metabolic Process;Decarboxylation;Endocrine;Estrogen decline;Estrogens;Event;Extracellular Matrix;Failure;Gene Expression;glucose metabolism;Goals;Gonadal Steroid Hormones;GPRC6A gene;hallmarks of aging;Histology;Homeostasis;Hormonal;Hormones;Human;Hyperglycemia;Immunohistochemistry;In Vitro;Insulin;insulin secretion;insulin sensitivity;islet;Islets of Langerhans;Kidney;Light;Mediating;Menopause;Metabolic;Modification;Molecular;Monitor;Mus;mutant mouse model;Normalcy;Orchiectomy;Organ;Osteoblasts;Osteocalcin;Osteogenesis;Ovariectomy;Pancreas;pharmacologic;Physiological;Postmenopause;preservation;Process;Production;Proliferating;Rattus;receptor;Regulation;sensor;Serum;Signal Transduction;Stress;stressor;Structure of beta Cell of islet;Testing;Time;Wild Type Mouse;Woman

PROJECT_TITLE: Impact of gonadal failure on the bone-mediated regulation of glucose metabolism


ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE Peripheral artery disease (PAD) is atherosclerotic disease with a blood flow obstruction to the lower extremities. Supervised exercise is commonly recommended for PAD patients whereas an exaggerated blood pressure response during exercise is a risk factor for cardiovascular diseases. This grant is to examine the role played by amiloride in improving the exaggerated sympathetic and blood pressure responses to exercise in PAD and further study the cellular mechanisms by which amiloride has beneficial effects, providing a potential base for better improving the blood flow directed to the ischemic limbs and enhancing walking ability in PAD patients.

PI_NAMEs: CUI, JIAN ;LI, JIANHUA  (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: afferent nerve;Afferent Neurons;Amiloride;Animals;antinociception;Arachidonic Acids;artery occlusion;ASIC channel;Atherosclerosis;Attenuated;base;Blood flow;Blood Pressure;blood pressure elevation;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;claudication;Contracts;Data;disability;Exercise;exercise training;Experimental Models;experimental study;FDA approved;femoral artery;Goals;Grant;Hindlimb;Human;improved;interstitial;Ischemia;Knock-out;Leg;Ligation;limb ischemia;Lower Extremity;Modeling;Muscle;Nerve;Obstruction;Oxidative Stress;Patients;Peripheral arterial disease;Placebos;Play;Process;Proteins;Rattus;Recommendation;Reflex action;Reperfusion Injury;Reperfusion Therapy;response;revascularization;Role;Stress;Time;Tissues;treadmill;Walking

PROJECT_TITLE: Exercise Pressor Reflex in Peripheral Artery Disease: Roles of Flow Limitation and Reperfusion

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Organ Transplantation;Transplantation

ORG_CITY: Fairfax

ORG_NAME: INOVA HEALTH CARE SERVICES

ORG_STATE: VA

PHR: Project Narrative  Two leading causes of morbidity and mortality in cardiac transplant recipients are allograft rejection and cardiac allograft vasculopathy. Diagnosing these conditions requires repetitive invasive procedures with inherent risks and varying diagnostic yield. Preliminary data suggests that circulating, cell-free microRNAs are novel, non-invasive biomarkers; using next-generation sequencing and bioinformatic analysis, we will identify circulating microRNA biomarkers that can be used to predict rejection and cardiac allograft vasculopathy.

PI_NAMEs: SHAH, PALAK  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;Accounting;accurate diagnosis;Acute;Adverse event;allograft rejection;Angiography;antibody-mediated rejection;assay development;Binding;biobank;Bioinformatics;Biological Assay;Biological Markers;biomarker discovery;biomarker panel;biomarker validation;Biometry;Biopsy;Blood;Blood specimen;Blood Tests;blood-based biomarker;Bronchiolitis Obliterans;Cardiovascular system;career;career development;cell free DNA;Cells;Cessation of life;Chronic;Chronic Kidney Failure;circulating microRNA;Clinical;Clinical Data;Clinical Management;Clinical Research;Clinical Trials;comorbidity;Coronary;Coronary Arteriosclerosis;cost;Data;Development;Development Plans;Diagnosis;Diagnostic;diagnostic biomarker;differential expression;Disease;experience;Faculty;Funding;Future;genomic biomarker;Genomics;Goals;graft dysfunction;Graft Rejection;heart allograft;Heart failure;Heart Transplantation;Human;in-vitro diagnostics;Incidence;indexing;Infrastructure;K-Series Research Career Programs;left ventricular assist device;Lung Transplantation;Malignant Neoplasms;Mediating;Medicine;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Messenger RNA;microRNA biomarkers;MicroRNAs;Monitor;Morbidity - disease rate;mortality;Multicenter Studies;Multicenter Trials;Myocardial tissue;Necrosis;next generation sequencing;Non-Invasive Detection;noninvasive diagnosis;novel;Nucleotides;organ transplant recipient;Outcome;Patients;Plasma;post-transplant;Preparation;Procedures;Research;Research Personnel;Research Proposals;Risk;Risk Factors;Role;Solid;Specimen;Supervision;Syndrome;T-Lymphocyte;Training;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translational Repression;Translational Research;Transplant Recipients;Transplantation;trial design;Untranslated RNA;Validation;Vascular Diseases;Work

PROJECT_TITLE: MicroRNA Biomarkers of Allograft Rejection and Cardiac Allograft Vasculopathy in Cardiac Transplantation


PI_NAMEs: ZELTSER, LORI M (contact)

PROJECT_TERMS: absorption;Acute;Adipocytes;age related;age related decline;aged;Aging;aging population;aging process;Alendronate;Animal Model;associated symptom;base;Biological Process;blood glucose regulation;Body System;bone;Bone remodeling;Bone Resorption;Brain;Brown Fat;Chronic;Cognition;design;Deterioration;Diet;diet-induced obesity;Energy Metabolism;Estrogens;Exercise;experimental study;Fatty Acids;feeding;Fertility;Functional disorder;Genes;Glean;Glucose;glucose tolerance;glucose uptake;GPRC6A gene;High Fat Diet;Histology;Hormones;Hot flushes;Human;Impairment;improved;In Vitro;in vivo;insight;life span;Mediator;Metabolic;Metabolic dysfunction;Modeling;Molecular;mouse model;Mus;mutant;National Institute on Aging;natural hypothermia;nerve supply;novel;Obesity;obesogenic;old mice;Organ;osmotic minipump;Osteocalcin;Ovariectomy;Perimenopause;Pharmaceutical Preparations;pharmacologic;Physiologic Thermoregulation;Physiological;Physiological Processes;Population;Predisposition;Process;programs;receptor;Regulation;Research;Research Design;Resources;response;Risk;Role;sensor;Signal Transduction;Stress;surgical menopause;Sympathetic Nervous System;Sympathomimetics;Tail;Thermogenesis;Time;Vasomotor;vasomotor symptoms;Wild Type Mouse;Woman;young adult

PROJECT_TITLE: Molecular bases of the regulation of energy expenditure by bone


NIH_SPENDING_CATS: Genetics;Human Genome;Nutrition

ORG_CITY: MADISON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative: To effectively perform their function, each cell type in the human body must respond appropriately to incoming signals and cells enlist specific machines to carryout cell-type unique instructions, a layer of information (called the epigenome) on top of the genome. This proposal will investigate how these molecular machines ‘interpret’ incoming signals, ‘read’ the existing epigenetic landscape and ‘respond’ appropriately. Knowledge of this communication network is key to understanding how major breakdowns in information flow, either as a lack of response to extra-cellular signals or to an ill-advised decision, leads to disease states.

PI_NAMEs: DENU, JOHN M (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Acceleration;Acetyl Coenzyme A;Acetylation;Acetyltransferase;alpha ketoglutarate;Animals;Biochemical;Biochemistry;Biophysics;Catalysis;Cell Physiology;cell type;Cells;Chromatin;Communication;Deacetylase;Deacetylation;Diet;Disease;DNA Methylation;DNA Sequence;drug development;Environment;Enzymes;Epigenetic Process;epigenome;Etiology;extracellular;Foundations;Gene Expression;Genetic;Genome;Goals;Histones;Human body;In Vitro;insight;Instruction;Investigation;Knowledge;Link;Lysine;Macronutrients Nutrition;Metabolism;Methylation;Methyltransferase;microbiota;Modeling;Molecular;Molecular Machines;Nicotinamide adenine dinucleotide;non-histone protein;Nuclear;Nucleosomes;Pathway interactions;Pharmacology;Post-Translational Protein Processing;Production;Protein Acetylation;Proteins;Research;response;S-Adenosylhomocysteine;S-Adenosylmethionine;Signal Pathway;Signal Transduction;Sirtuins;Untranslated RNA;Work

PROJECT_TITLE: Dynamics and molecular mechanisms linking metabolism and the epigenome

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Deep brain stimulation is a surgical procedure for the treatment of Parkinson’s disease. A novel approach to current DBS is called coordinated reset DBS which uses different patterns of stimulation at lower currents and can also induce motor improvement that persist after cessation of stimulation. This study will assess critical features and optimal target site for CR DBS that provide optimal clinical outcomes.

PI_NAMEs: WANG, JING  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine;Acute;Advanced Development;Adverse effects;Affect;Animals;Area;Basal Ganglia;battery life;battery recharging;Behavioral;Biological Markers;Brain;Clinical;Clinical Research;Consumption;Data;Deep Brain Stimulation;deep brain stimulation array;density;Development;Dorsal;effective therapy;Effectiveness;Energy consumption;Evaluation;Experimental Designs;Frequencies;Future;Globus Pallidus;Goals;Healthcare Systems;Hour;human subject;Implant;improved;Incidence;Lead;Measures;Modeling;Motor;motor disorder;motor function improvement;motor symptom;Movement;neural;Neurodegenerative Disorders;Neurons;neurotransmission;Nodal;nonhuman primate;novel;novel strategies;Operative Surgical Procedures;Outcome;Parkinson Disease;Parkinsonian Disorders;Patient Care;Patients;Pattern;Persons;preclinical study;Prefrontal Cortex;Probability;Quality of life;Research;Rest;side effect;Site;specific biomarkers;Structure;Structure of subthalamic nucleus;Testing;Therapeutic;Therapeutic Effect;therapeutically effective;Time;translational therapeutics;Translations;Utah;Work

PROJECT_TITLE: Optimizing coordinated reset deep brain stimulation for Parkinson's disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Human Genome;Kidney Disease;Lupus

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE This study determines how cytokines like interferon influence the development of autoimmunity-associated B cells and autoreactive plasma cells in systemic lupus erythematosus. Kidney tissue is examined to determine if autoimmunity-associated B cell precursors and autoimmunity-promoting factors are found in lupus nephritis. Understanding how these abnormal B cells develop into cells that make self-reactive antibodies may lead to new treatment strategies for lupus and lupus nephritis.

PI_NAMEs: BARNAS, JENNIFER LYNN (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acceleration;Address;Affect;ATAC-seq;Autoantibodies;Autoimmune Diseases;Autoimmunity;autoreactivity;B cell differentiation;B-Cell Activation;B-Lymphocytes;Biometry;Blood;career development;CD11 Antigens;Cell Lineage;Cells;Cellular biology;Chromosomes;clinically relevant;Collaborations;cytokine;Data;Development;Development Plans;Disease;Doctor of Philosophy;Epigenetic Process;epigenetic regulation;epigenomics;Event;experience;Family;Flow Cytometry;Food and Drug Administration Drug Approval;Fostering;Frequencies;Functional disorder;Funding;Gene Expression;Genes;Human;human disease;human tissue;Immune;Immunohistochemistry;In Situ;In Vitro;in vivo;indexing;Institution;Interferon Activation;Interferon Type II;Interferons;interleukin-21;IRF4 gene;ITGAX gene;Kidney;kidney biopsy;large datasets;Literature;Lupus;Lupus Nephritis;Lymphocyte;Maps;Measures;Medicine;Mentorship;Molecular;new therapeutic target;novel;novel therapeutic intervention;Nuclear;Organ;Participant;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;peripheral blood;Phase;phase 2 study;Phosphorylation;plasma cell development;plasma cell differentiation;Plasma Cells;Plasma Enhancement;Population;Positioning Attribute;PRDM1 gene;precursor cell;Procedures;Production;programs;Refractory;Renal tubule structure;Research;research and development;Research Personnel;Role;Signal Transduction;single cell analysis;single cell sequencing;single-cell RNA sequencing;skills;STAT1 gene;System;Systemic Lupus Erythematosus;T-bet protein;T-Lymphocyte;Techniques;Testing;therapeutic target;Time;Tissue Sample;Tissues;TLR7 gene;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Autoimmunity-Associated B Cells in Lupus Nephritis

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

PHR: Narrative This proposal takes advantage of the ability of pluripotent stem cells to uniquely produce differentiated somatic cell types in large quantities. This allows the generation of specific cell populations for regenerative medicine. We have developed methods, based on the conditional expression of myogenic master regulators, Pax3 and Pax7, to induce the muscle program in early mesoderm, and thus derive embryonic muscle progenitors with great efficiency. Our investigations will focus on understanding the interaction and molecular cues provided by the adult niche that favor the in vivo maturation of PSC-derived myogenic progenitors, as well as the clonal dynamics of engraftment and quiescence.

PI_NAMEs: PERLINGEIRO, RITA C. R. (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Address;Adult;Bar Codes;Biochemical;Biological Assay;CD34 gene;Cell Compartmentation;Cell Fraction;Cell Transplantation;cell type;Cells;Cues;Development;Disease;donor stem cell;Embryo;Endowment;Engraftment;Environment;Exposure to;fetal;gain of function;Generations;High-Throughput Nucleotide Sequencing;Human;In Vitro;in vivo;induced pluripotent stem cell;Injury;Integrins;Investigation;loss of function;Mesoderm;Methods;MicroRNAs;Molecular;Molecular Profiling;Mononuclear;Mus;Muscle;muscle regeneration;Muscle satellite cell;Myoblasts;Natural regeneration;Neonatal;notch protein;Outcome;Pathway interactions;Play;Pluripotent Stem Cells;Population;Post-Transcriptional Regulation;Process;progenitor;programs;Proteins;regeneration potential;Regenerative Medicine;Research;Role;self-renewal;Signal Pathway;Signal Transduction;skeletal;Skeletal Muscle;Somatic Cell;Source;stem cells;Time;tool;transcriptome;Transplantation;United States National Institutes of Health;virus genetics

PROJECT_TITLE: Skeletal Muscle Regeneration from Pluripotent Stem Cells

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

PHR: Narrative HIV-associated neurological disorder (HAND) in various forms affects about 50% of HIV-infected population and persists despite effective anti-retroviral treatment. The treatment options for this co-morbidity are limited because of poor understanding of its pathogenic mechanisms. In this proposal, we will test an innovative hypothesis that HAND is caused by HIV-mediated impairment of cholesterol metabolism in brain cells.

PI_NAMEs: BUKRINSKY, MICHAEL ILYA (contact);SVIRIDOV, DMITRI ;TYOR, WILLIAM R

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acceleration;Adverse effects;Affect;age acceleration;aged;Aging;aging population;aging related disease;AIDS dementia;Alzheimer's Disease;Animal Model;Anti-Retroviral Agents;antiretroviral therapy;Apolipoprotein A-I;Apoptosis;Astrocytes;ATP binding cassette transporter 1;Automobile Driving;Behavioral;Binding Proteins;Brain;brain cell;Cells;Central Nervous System Diseases;Cholesterol;Cholesterol Homeostasis;cholesterol transporters;Chronic;Clinical;Communication;comorbidity;Development;Disease;Down-Regulation;effective therapy;Elements;executive function;exosome;Exposure to;extracellular vesicles;Functional disorder;Functional impairment;Genetic Transcription;Health;HIV;HIV Infections;HIV-associated neurocognitive disorder;Impaired cognition;Impairment;in vitro testing;in vivo;Incidence;Individual;Inflammation;Inflammatory Response;inhibitor;innovation;Learning;Life Cycle Stages;Life Expectancy;Macrophage;Mediating;Membrane Microdomains;Microglia;Modeling;Morphology;mouse model;Mus;nef Protein;Nerve Degeneration;Nervous System Disorder;neuroAIDS;Neurocognitive Deficit;neurocognitive disorder;Neurodegenerative Disorders;neuroinflammation;Neurologic;Neurologic Dysfunctions;Neurologic Symptoms;Neurons;neurotoxicity;novel;novel strategies;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Persons;Pharmaceutical Preparations;Physiological;Population;prevent;Prions;Production;protein aggregation;protein misfolding;Publishing;Quality of life;Risk;Severities;Testing;Therapeutic;Therapeutic Agents;Translating;Translations;Viral Proteins;Viral reservoir

PROJECT_TITLE: Novel pathogenic mechanism of HIV-associated CNS neurological disorders

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE  Despite the rapidly growing rate of obesity, the development of safe and effective therapeutics has become progressively more promising, yet still limited, largely due to insufficient understanding of how the brain manages body weight and feeding. Serotonin remains an excellent potential target for an anti- obesity therapeutic, but there is a gap in understanding of the most effective way to utilize serotonin as a tool for weight loss. This proposal will focus on how 5-HT (serotonin) neurons are regulated by dopamine and/or GABA, and how these inputs contribute to the meal initiation.

PI_NAMEs: MCDERMOTT, KRISTINE MARIE (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Action Potentials;Agonist;American;Animals;Area;Body System;Body Weight;Body Weight decreased;Brain;cancer risk;career;college;comorbidity;comparison control;Consumption;Data;Development;Diabetes Mellitus;Dopamine;Dopamine D2 Receptor;Dopamine Receptor;dorsal raphe nucleus;DRD2 gene;Eating;Electrophysiology (science);energy balance;Energy Intake;Energy Metabolism;Enzymes;feeding;Feeding behaviors;Fellowship;Fenfluramine;Fiber;Food;Food Intake Regulation;Functional disorder;GABA Receptor;gamma-Aminobutyric Acid;global health;Goals;Health;Homeostasis;Hunger;Hyperphagia;Hypertension;Hypothalamic structure;improved;Infection;Institution;Intake;Learning;Long-Term Potentiation;Mediating;Medicine;Membrane Potentials;Mental Depression;Metabolic;Modeling;Moods;Mus;Neural Pathways;neurobiological mechanism;Neurons;neurotransmission;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutritional;obese person;Obesity;obesity prevention;optogenetics;Outcome;Overweight;Pattern;Pharmaceutical Preparations;Photometry;Physiological;Play;postsynaptic;Prevalence;prevent;Property;Protocols documentation;receptor;reduced food intake;Regimen;Regulation;Research;Resources;response;Rest;Risk;Role;SARS-CoV-2 infection;Satiation;Scientist;Serotonin;side effect;Signal Transduction;Structure of nucleus infundibularis hypothalami;success;System;Testing;Therapeutic;therapeutic development;therapeutically effective;tool;TPH2;Training;Wild Type Mouse;Work

PROJECT_TITLE: 5-HT NEURONS AND MEAL REGULATION


ORG_CITY: PHILADELPHIA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative PGD occurs in almost a third of lung transplant recipients, is the most common cause of death in the perioperative period and has a major impact on morbidity, quality of life and cost. Uncertainty in organ quality and concern that poor donor quality causes susceptibility to PGD results in high discard rates for potentially transplantable organs. The long-term objective of this line of research is to develop objective tools to stratify PGD risk so more organs will be used for transplant and high-risk organs can be identified early for advanced therapies.

PI_NAMEs: CANTU, EDWARD  (contact)

PROGRAM_OFFICER_NAME: CHARYA, ANANTH VELUGALETI

PROJECT_TERMS: Acute;Acute Lung Injury;Address;Affect;American;Assessment tool;biomarker identification;Blood;Body Temperature;candidate selection;Cause of Death;Cessation of life;Chronic lung disease;Clinical;clinical predictors;clinical trial enrollment;Cohort Studies;Collaborations;Complex;cost;Decision Making;Disease;Donor person;Donor Selection;Early identification;Fright;Funding;Future;Gene Expression;graft dysfunction;high risk;Hour;Hypoxia;immune activation;implantation;improved;Infiltration;Infrastructure;innate immune pathways;Knowledge;Life;Lung;lung injury;Lung Transplantation;Measures;Methods;Morbidity - disease rate;mortality;Multicenter Studies;new technology;novel;oncology trial;Organ;Organ Donor;Organ failure;Organ Procurements;Organ Transplantation;Outcome;Pathogenesis;Pathway interactions;Patients;Perfusion;Perioperative;Population;Positioning Attribute;Postoperative Period;predictive tools;Predisposition;Preparation;prevent;Preventive;Probability;prospective;Prospective cohort;Public Health;Quality of life;radiological imaging;Reproducibility;Research;Risk;Risk Assessment;risk stratification;Selection Criteria;Signal Pathway;Specialized Center;Structure of parenchyma of lung;Syndrome;Technology;Therapeutic;Toll-Like Receptor Pathway;Toll-like receptors;tool;Transcript;transplant centers;Transplant Recipients;Transplantation;Uncertainty;United States National Institutes of Health;Update;ventilation;Waiting Lists;Work

PROJECT_TITLE: Objective lung assessment tools for improved organ use in lung transplantation

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Project Narrative (Overall) The National Pediatric Rehabilitation Resource Center is designed to increase the capacity of investigators from many disciplines to conduct scientifically rigorous, high-impact clinical research in pediatric medical rehabilitation. In turn, new discoveries about effective treatments have the potential to produce lifelong benefits in the health, productivity, and quality of life of those affected by childhood-onset disabilities.

PI_NAMEs: RAMEY, SHARON LANDESMAN (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Address;Advertising;Affect;Archives;biobehavior;Biomedical Engineering;Biotechnology;Cerebral Palsy;Child;Childhood;Clinical;Clinical and Translational Science Awards;Clinical Research;Clinical Trials;Collaborations;Communities;Complex;Data;design;Development;disability;Discipline;Disease;Educational workshop;effective therapy;efficacious intervention;Ensure;Equity;Evaluation;Evidence based intervention;Evidence based treatment;functional improvement;functional outcomes;Funding;Health;Impairment;implementation science;improved;Individual;innovation;Institution;Interdisciplinary Study;Knowledge;Leadership;Manuals;Measurement;Mentors;Monitor;Multi-Institutional Clinical Trial;National Institute of Child Health and Human Development;National Institute of Neurological Disorders and Stroke;neurobiological mechanism;neuroimaging;Neurosciences;novel strategies;Occupational Therapy;Ohio;Onset of illness;Outcome;outreach;Parents;Patients;Pediatric Hospitals;Pediatric Neurology;Phase;Physical therapy;Pilot Projects;Population;Productivity;programs;Quality of life;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;Regulation;rehabilitation research;rehabilitation science;Rehabilitation therapy;Reporting;Research;Research Design;Research Infrastructure;Research Personnel;Resources;Role;Science;Site;special interest group;Strategic Planning;success;technique development;Techniques;Testing;Training Programs;United States National Institutes of Health;Universities;Update;Virginia;Vision;webinar;Work


PI_NAMEs: DELUCA, STEPHANIE C. (contact)

PROJECT_TERMS: Advocacy;Age;Archives;Area;Biomedical Engineering;Biometry;Brain;Child;Child Development;Childhood;Clinical;Clinical Trials;Collaborations;Communities;Complex;Data;Data Analyses;design;Development;Discipline;Educational Activities;Educational workshop;efficacious treatment;Eligibility Determination;Event;Face;follow-up;Goals;Heterogeneity;implementation science;improved;Infrastructure;innovation;interest;Interest Group;International;Intervention;Link;Measurement;Measures;meetings;Neonatology;Neurosciences;Occupational Therapy;Outcome Measure;Parents;Patients;Pediatric Neurology;Pediatrics;Physical Medicine;Physical Rehabilitation;Physical therapy;Pilot Projects;Population;programs;rehabilitation research;Rehabilitation therapy;Research;Research Design;Research Personnel;Resources;response;Science;Scientist;special interest group;Structure;Subgroup;success;symposium;Testing;tool;Treatment Protocols;trial design;Underrepresented Populations;United States National Institutes of Health;Update;web site;webinar;Work

PROJECT_TITLE: National Pediatric Rehabilitation Resource Center: Didactic Interactions


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Choroid plexus vascular malformations substantially increase the risk of an intraventricular hemorrhagic stroke which can cause dangerous increases in intracranial pressure as well as hydrocephalus and serious brain damage. The goal of our proposed studies is to understand the molecular and genetic control of choroid plexus vascular development and morphogenesis, providing critical insights into its pathological processes. This research has the potential to reveal novel therapeutic targets to treat or prevent vascular diseases of the choroid plexus as well as in other parts of the central nervous system.

PI_NAMEs: MATSUOKA, RYOTA  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Ablation;Address;Anatomy;angiogenesis;autocrine;Bacterial Artificial Chromosomes;Biological Process;Biology;Blood;Blood - brain barrier anatomy;blood cerebrospinal fluid barrier;Blood Vessels;blood-brain barrier permeabilization;Brain;Brain hemorrhage;Brain Injuries;Central Nervous System;Cerebral Ventricles;Cerebrospinal Fluid;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Choroid Diseases;Choroid Plexus Epithelium;Code;Cues;Dangerousness;Data;design;Development;Disease;Dissection;Electron Microscopy;Endothelial Cells;Endothelial Growth Factors Receptor;Endothelium;Epithelial Cells;Epithelium;Functional disorder;gain of function;Generations;Genetic;Genetic study;Glean;Goals;Homeostasis;Hydrocephalus;imaging genetics;Imaging technology;innovation;insight;Intracranial Pressure;intraventricular hemorrhage;Knowledge;knowledge base;Lasers;Lead;Long term disability;loss of function;Lymphangiogenesis;malformation;Mammals;Mediating;Meninges;Metabolic;Methods;Modeling;Molecular;Molecular Genetics;molecular targeted therapies;Morphogenesis;mosaic analysis;Movement;mutant;Mutation;neurovascular;new therapeutic target;novel;Organ;Orthologous Gene;overexpression;paracrine;Paracrine Communication;paralogous gene;Pathogenesis;Pathologic Processes;Pathway interactions;Pattern;Permeability;pharmacologic;Phenotype;Physiology;PIK3CG gene;Play;prevent;Process;receptor;Reporter Genes;Reporting;Research;Risk;Role;Signal Pathway;Signal Transduction;spatiotemporal;Specificity;Structure of choroid plexus;Testing;Therapeutic;Tight Junctions;Tissues;tool;Transgenic Organisms;two-photon;Vascular Diseases;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factors;Vascularization;VEGFA gene;wasting;Work;Zebrafish

PROJECT_TITLE: Molecular Genetic Dissection of Fenestrated Vascular Development in the Choroid Plexus

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences;Pediatric;Physical Rehabilitation;Rehabilitation

PI_NAMEs: LO, WARREN DAVID (contact)

PROJECT_TERMS: Active Learning;Adolescence;Behavioral;Biomechanics;career;Childhood;Clinic;Clinical and Translational Science Awards;clinical research site;Collaborations;comparative effectiveness;Competence;Consultations;Dedications;detector;Education;Effectiveness;experience;Feedback;follow-up;Funding;Grant;Home;Human;Immersion;implementation science;Individual;Infant;injury prevention;Institution;Interest Group;International;K-Series Research Career Programs;Knowledge;meetings;member;Mentors;Motion;neonatal period;neuroimaging;novel;Ohio;Participant;Pediatric Hospitals;Phase;Phase III Clinical Trials;Pilot Projects;Positioning Attribute;Practice based research;Prevention Research;Productivity;Recording of previous events;rehabilitation research;Rehabilitation therapy;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;sabbatical;Science;Scientist;Site;skills;Training and Infrastructure;Travel;Underrepresented Populations;United States National Institutes of Health;Universities;Virginia;virtual;Visit;Work

PROJECT_TITLE: National Pediatric Rehabilitation Resource Center: Mentored Collaborative Opportunities


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Mouse models of organ transplantation offer a reliable, reproducible and clinically relevant method to study immune factors affecting graft survival. Immune responses differ between various transplantable organs. We plan to study immune responses specific to transplanted lungs.

PI_NAMEs: KREISEL, DANIEL  (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acute;adaptive immune response;Affect;Allograft Tolerance;antibody-mediated rejection;Area;Bronchiolitis;Bronchus-Associated Lymphoid Tissue;Cells;Chronic;clinically relevant;Collaborations;Cues;Development;Event;Functional disorder;Funding;graft failure;Graft Rejection;Graft Survival;Human;imaging approach;Immune;Immune response;Immunologic Factors;Immunologics;immunoregulation;Immunosuppression;improved outcome;Inflammatory;innovation;insight;intravital imaging;Knowledge;Laboratories;Lung;lung allograft;Lung Diseases;Lung Transplantation;Lymphoid;Maintenance;Mediating;Mediator;Methods;Molecular;mouse model;novel;novel therapeutic intervention;novel therapeutics;Organ;Organ Transplantation;Outcome;Pathologic;Pathway interactions;Patient imaging;Patients;Physicians;Physiological;Population;Productivity;programs;Protocols documentation;Regimen;Reproducibility;Research;Role;Scientist;Survival Rate;synergism;tertiary lymphoid organ;Tissues;Transplant Recipients;Transplantation;Transplantation Tolerance;Work

PROJECT_TITLE: Pathways Regulating Lung Transplant Tolerance.


PI_NAMEs: GELMAN, ANDREW ERIC (contact)

PROJECT_TITLE: Administrative Core


PI_NAMEs: LI, WENJUN  (contact)

PROJECT_TERMS: Acute;Address;antibody-mediated rejection;Biology;Cell Communication;Chronic;clinically relevant;Collaborations;Data;Dedications;Ensure;Event;experimental study;Flow Cytometry;Functional disorder;Funding;Gene Expression Profiling;Goals;graft function;Graft Rejection;Graft Tolerance;Histology;Human;Imaging Techniques;immune imaging;Immune response;Immunologics;insight;intravital imaging;Laboratories;Left;Lung;lung allograft;lung failure;Lung Transplantation;Microsurgery;Minor;Modeling;mouse model;Mus;novel strategies;Operative Surgical Procedures;Organ;Organ Transplantation;Outcome;Pathologic;Pathway interactions;Physiological;Play;Preparation;Procedures;programs;Protocols documentation;Reperfusion Injury;Reproducibility;response;retransplantation;Role;Serum;Solid;Specimen;Standardization;Surgeon;System;Techniques;therapy development;Time;Tissue Harvesting;Tissues;tool;Training;Translating;transplant model;Transplant Recipients;Transplantation;Transplantation Immunology;Transplantation Surgery;Transplantation Tolerance;two photon microscopy;Universities;Variant;Vascularization;Virginia;Washington

PROJECT_TITLE: Microsurgery Core


PROJECT_TERMS: airway epithelium;Allogenic;Antibodies;antibody-mediated rejection;B-Cell Activation;B-Lymphocytes;Binding;Bronchus-Associated Lymphoid Tissue;CCL17 gene;CCL22 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Differentiation process;Cells;chemokine;Chronic;Clinic;clinically relevant;Data;Development;donor-specific antibody;eosinophil;experience;extracellular;FOXP3 gene;Generations;Graft Rejection;Graft Tolerance;Heart Transplantation;Helper-Inducer T-Lymphocyte;Immune;Immune response;immunoregulation;Immunosuppression;Impairment;improved outcome;Infection;Infiltration;Interferon Type II;ITGAX gene;Kidney Transplantation;Knowledge;Laboratories;liver transplantation;Lung;lung allograft;Lung Diseases;lung failure;Lung Transplantation;Lymphocyte;Lymphoid;Macrophage;Maintenance;Mediating;monocyte;mouse model;Natural Killer Cells;neutrophil;Neutrophil Infiltration;novel;novel therapeutics;Organ;Outcome;pathogen;Pathogenesis;Pathway interactions;Patients;Pattern;Play;Population;prevent;Procedures;Production;Protocols documentation;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;recruit;Refractory;Regulation;Regulatory Pathway;Reporting;Research;response;retransplantation;Role;Solid;synergism;T cell infiltration;T-Lymphocyte;Techniques;therapy development;Tissue Transplantation;Tissues;Transplant Recipients;Transplantation;Transplantation Tolerance;treatment choice;Work

PROJECT_TITLE: The Role of Lymphoid Neogenesis in the Maintenance of Lung Transplant Tolerance


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Cerebral Palsy;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Rehabilitation

PI_NAMEs: HEATHCOCK, JILL C. (contact)

PROJECT_TERMS: Adherence;Advanced Development;Age;Area;Assessment tool;Behavior;Behavioral;Biological Markers;Biomedical Research;Brain;Categories;Cerebral Palsy;Child;Childhood;Clinical;clinical application;clinical practice;Clinical Trials;Common Data Element;Communities;constraint induced movement therapy;Data Reporting;data standards;Documentation;dosage;Environment;Etiology;Failure;Frequencies;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Future;Impairment;Incentives;Individual;Infant;Intervention;Investments;kinematics;Laboratories;Manuals;Measures;Mentors;Methods;Modification;Movement;neuroimaging;Neuronal Plasticity;novel;novel strategies;off-label use;Ohio;Outcome Measure;Parents;Patient Self-Report;Pattern;Pediatric Hospitals;Performance;primary outcome;Property;Psychometrics;Recommendation;rehabilitation research;Rehabilitation therapy;Reporting;Research;Research Institute;Research Personnel;Resources;Rest;robotic device;Science;Scientist;Scoring Method;secondary outcome;Senior Scientist;Severities;skills;Sleep;Specificity;Standardization;technique development;Techniques;Technology;technology development;Testing;Time;tool;Treatment Protocols;Universities;Validation;Virginia;wearable device;Work

PROJECT_TITLE: National Pediatric Rehabilitation Resource Center: Techniques Development