ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: More than one third of epileptic patients have recurrent spontaneous seizures that cannot be treated with drugs. While optogenetic control of light-sensitized neurons can suppress seizures, our limited access to relevant neural circuits and the surgical implantation of external devices is a major barrier for clinical translation. Using a newly discovered potent protein actuator and viral-targeting strategy, this proposal will implement noninvasive optogenetics for long-term control of wild-type animals with drug-refractory epilepsy.

PI_NAMEs: CHEN, RITCHIE  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Affect;Animal Model;Animals;Anterior Nuclear Group;Anticonvulsants;Behavior;biomaterial compatibility;Brain;Canis familiaris;career;career development;cell type;Central Nervous System;Cephalic;Cerebellar Cortex;Cerebellum;Chronic;Cicatrix;Clinical;clinical translation;Cognitive;Collaborations;comorbidity;Computer Analysis;Core Facility;Coupling;cranium;Deep Brain Stimulation;Development;Devices;Electrodes;Electrophysiology (science);Engineering;Environment;Epilepsy;experience;experimental study;Fiber Optics;Focal Seizure;Foundations;Future;Gene Delivery;gene therapy;Generalized seizures;Genetic Complementation Test;Gliosis;Goals;Grant;Hippocampus;Implant;implantation;improved;Individual;Interneurons;Intervention;Intractable Epilepsy;Light;light emission;light gated;Location;Mammals;Manuscripts;Maps;Mentors;Methodology;Methods;Modality;Modeling;motor control;Motor Cortex;mouse model;Mus;nanoparticle;Nervous System Disorder;neural;neural circuit;neural implant;neural network;neuroinflammation;neuromechanism;Neurons;neuroregulation;Neurosciences;nonhuman primate;novel;novel therapeutics;Nucleus fastigii;Operative Surgical Procedures;Opsin;optical fiber;Optics;optogenetics;Output;Partial Epilepsies;Pathology;Patients;Pharmaceutical Preparations;Phase;photoactivation;Play;Presynaptic Terminals;Proteins;Public Speaking;Purkinje Cells;Rattus;Recurrence;redshift;Refractory;Research;Research Personnel;Research Project Grants;Role;Seizures;side effect;Silicon Dioxide;Somatosensory Cortex;Specificity;superior colliculus Corpora quadrigemina;System;technique development;Techniques;Technology;Testing;Therapeutic;therapeutic target;therapy development;Tissues;tool;Training;Transgenic Mice;treatment strategy;Universities;Viral;waveguide;Work;Writing

PROJECT_TITLE: Noninvasive Optogenetic Interventions for Epilepsy

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: The world is in need of an effective HIV/AIDS vaccine, and the cytomegalovirus (CMV) vector-based HIV/SIV vaccine featured in our studies is highly efficacious and durable to uniquely mediate viral “replication arrest” efficacy in the Rhesus Macaque-SIV model. Vaccine immunity is mediated by unconventional MHC-E-restricted CD8+ T cell responses and induction of IL-15, which correlate with vaccine protection. The work proposed in this application will reveal the molecular mechanisms of immune programming by the CMV-based vaccine and IL- 15 actions to inform human testing of this vaccine concept in ongoing and future phase I/II trials.

PI_NAMEs: GALE, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BOGGIANO, CESAR AUGUSTO

PROJECT_TERMS: Acute;Address;Animals;Autopsy;Bioinformatics;Biological Markers;biomarker signature;Blood;cancer immunotherapy;CD8-Positive T-Lymphocytes;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Clinical Research;cohort;Coupled;Cytomegalovirus;Cytomegalovirus Vaccines;design;Disease;efficacy outcomes;Epitopes;Exhibits;Extinction;Foundations;Frequencies;Future;Gene Expression;Gene Expression Profile;gene network;Genes;genetic signature;HIV;HIV Antigens;HIV vaccine;Human;Immune;immune activation;Immune response;Immunity;Immunologics;In Vitro;in vivo;Infection;Inflammatory;Intercept;Interleukin-15;Knowledge;Link;Macaca mulatta;Major Histocompatibility Complex;Mediating;Memory;Modality;Modeling;Molecular;Molecular Profiling;Monitor;monocyte;multiple omics;nano-string;nonhuman primate;outcome prediction;Pathogenicity;Pathway interactions;Pattern;Phase I/II Trial;preclinical study;Program Research Project Grants;programs;Research Design;response;response biomarker;Rhesus;Role;Services;Signal Pathway;Signal Transduction;single-cell RNA sequencing;SIV;SIV Vaccines;Statistical Models;System;Systems Biology;T cell differentiation;T cell response;T-Lymphocyte;Technology;Testing;Time;Tissues;transcriptome sequencing;transcriptomics;Translating;Vaccinated;Vaccination;vaccine development;vaccine efficacy;vaccine evaluation;vaccine platform;vaccine response;Vaccines;vaccinology;vector;vector induced;vector-based vaccine;Viral;Viremia;Virulent;Virus;Virus Diseases;Virus Replication;Whole Blood;Work

PROJECT_TITLE: MECHANISMS PROGRAMMING PROTECTIVE IMMUNITY FROM RhCMV-SIV VACCINE AND IL-15 ACTIONS


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: archive data;Biomedical Research;Budgets;Communicable Diseases;Communication;Communication Programs;data archive;data management;data sharing;data sharing networks;design;Ensure;experience;Goals;Guidelines;Human Resources;Immune;Immune System Diseases;Immunity;Institution;Interleukin-15;meetings;National Institute of Allergy and Infectious Disease;Natural Immunity;Office of Administrative Management;Play;Policies;Primates;Program Research Project Grants;programs;Progress Reports;Publications;Regulation;Reporting;Research;research and development;Research Personnel;Research Project Grants;Resource Sharing;Role;Schedule;SIV Vaccines;Structure;Teleconferences;translational medicine;United States National Institutes of Health;Universities;Virus;Washington

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Osteoporosis;Prevention;Sleep Research

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Our work has shown that humans exposed to several weeks of recurring 28-hour days to induce sleep restriction and circadian disruption (e.g., shift work, jet lag) had significantly decreased bone formation, with no change or an increase in bone resorption - an imbalance that could lead to bone loss, osteoporosis, and increased fracture risk. This R01 proposal will investigate the acute and chronic effects of real-world night shift work schedules on bone metabolism, density, quality and strength, and evaluate system-level mechanisms, including increased sympathetic tone. Results will inform screening recommendations for night shift workers, and introduce a paradigm shift in the prevention, evaluation, and treatment of osteoporosis.

PI_NAMEs: SWANSON, CHRISTINE M (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Acceleration;Acute;Adrenergic beta-Antagonists;Adrenergic Receptor;Adult;Adverse effects;animal data;Animals;Attention;Biochemical;bone;Bone Density;bone health;bone loss;bone mass;bone metabolism;Bone Resorption;bone strength;bone turnover;cardiovascular disorder risk;Cells;Cessation of life;Chronic;Circadian Dysregulation;Clinical;cohort;comparison control;Coupled;Data;density;Development;Evaluation;experience;exposed human population;Exposure to;follow-up;Fracture;fracture risk;functional independence;functional loss;Health;healthy aging;Hospital Nursing;Hour;Human;human data;Impairment;indexing;Individual;Jet Lag Syndrome;Knowledge;Life;Light;Malignant Neoplasms;Measures;men;Metabolic syndrome;modifiable risk;Morbidity - disease rate;mortality;novel;Nurses;Nurses' Health Study;Osteoblasts;Osteogenesis;Osteoporosis;Osteoporosis prevention;Participant;Pattern;Periodicity;Postmenopause;prevent;Prevention;Protocols documentation;Recommendation;Recovery;Recurrence;Reporting;Research;research clinical testing;Research Design;response;Risk Factors;Schedule;screening guidelines;shift work;skeletal;Sleep;Sleep disturbances;sleep pattern;Sleep Wake Cycle;Sympathetic Nervous System;System;Time;Woman;Work;young adult

PROJECT_TITLE: Fractured Schedules: Skeletal Effects of Acute and Chronic Night Shift Work


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Preventing epilepsy and its progression (epileptogenesis), and not just controlling seizure occurrence and severity, remains the Holy Grail for epilepsy research and therapy development. The current proposal will use a systematic approach to test the therapeutic efficacy for epilepsy prevention of different FDA-approved drugs and their combinations, which interact with the adenosine system (either upstream or downstream of adenosine). The expected outcome of this project is the development of a therapeutic strategy for epilepsy prevention based on the repurposing of existing FDA-approved drugs.

PI_NAMEs: BOISON, DETLEV  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: acquired epilepsy;Acute;Address;Adenosine;Adenosine Kinase;adenosine receptor activation;ADORA2A gene;Affect;Antibiotics;Antiepileptogenic;Applications Grants;astrogliosis;Azacitidine;Benchmarking;Brain;Ceftriaxone;Cell Nucleus;Chronic;Clinical;clinical development;clinical translation;Combined Modality Therapy;comparative efficacy;Cytoplasm;Data;design;Development;Disease;DNA Methylation;Dose;drug discovery;Drug Utilization;Enzymes;Epigenetic Process;Epilepsy;Epileptogenesis;Event;experimental study;extracellular;FDA approved;Foundations;Future;Genetic;glial activation;Glutamate Transporter;Glutamates;Goals;Homeostasis;Hour;Impairment;inhibitor;Injury;innovation;Kainic Acid;kinase inhibitor;Knowledge;Link;Measures;Mediating;Mediator;Metabolism;Modeling;Mus;National Institute of Neurological Disorders and Stroke;Neurologic;neuronal excitability;novel;Nuclear;Outcome;overexpression;Pathologic;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Play;Post-Traumatic Epilepsy;prevent;preventable epilepsy;Prevention strategy;Prevention therapy;Process;programs;Protein Isoforms;Purinergic P1 Receptors;Rattus;receptor;Research;research and development;response;Rodent Model;Role;Seizures;Severities;Signal Pathway;small molecule;Solid;Status Epilepticus;System;Temporal Lobe Epilepsy;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;therapy development;Time;Traumatic Brain Injury;Treatment Efficacy;uptake;Work

PROJECT_TITLE: Therapies for epilepsy prevention - focus on adenosine

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: DURHAM

ORG_DEPT: BIOLOGY

ORG_NAME: NORTH CAROLINA CENTRAL UNIVERSITY

ORG_STATE: NC

PHR: This proposed U54 Collaborative Partnership between NCCU and UNC involves increasing NCCU alcohol research and student research experiences in fetal alcohol toxicity, alcohol neurotoxicity, and alcohol-induced carcinogenesis and inflammation. Health disparities include increased severity of alcohol-related pathology. Collaborative partnerships that carry out integrated and focused research on the molecular mechanisms of alcohol pathology involving faculty and students from NCCU, a historically Black College or University, educate and involve future researchers on alcohol-related health disparities and provide opportunities for careers in medical fields as well as making discoveries on mechanisms that may lead to cures.

PI_NAMEs: COLE, GREGORY JAY (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Address;Adolescent;Adult;African American;African American population;African American student;Alcohol abuse;alcohol exposure;alcohol research;alcohol use disorder;Alcohols;Area;ARHGEF5 gene;Award;Behavioral;Brain;carcinogenesis;career;cellular pathology;Collaborations;Core Facility;Course Content;Data;Education;Educational Curriculum;Educational process of instructing;Endowment;Environment;Ethanol toxicity;expectation;experience;experimental study;Faculty;faculty mentor;fetal;Fetal Alcohol Spectrum Disorder;Funding;Future;Goals;graduate student;Grant;health disparity;Health Professional;Historically Black Colleges and Universities;improved;Inflammation;Infrastructure;Institution;interest;Internships;Joints;Knowledge;Laboratories;laboratory development;laboratory experience;Laboratory Research;Leadership;Learning;lectures;Malignant Breast Neoplasm;mammary;Manuscripts;Medical;Medical Libraries;medical schools;meetings;Mentors;Minority;minority investigator;Molecular;Morbidity - disease rate;National Institute on Alcohol Abuse and Alcoholism;Neuroimmune;neuropathology;neurotoxicity;North Carolina;Pathology;post-doctoral training;Preparation;Process;Productivity;programs;Publications;recruit;Research;research and development;Research Personnel;Research Project Grants;Research Technics;Resource Sharing;Resources;response;role model;Scholarship;Series;Severities;skills;stem cells;Structure;Students;success;summer internship;synergism;Techniques;Tissues;Toxic effect;Training;U-Series Cooperative Agreements;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;university student;virology;Work

PROJECT_TITLE: 1/2 Partnerships to Enhance Alcohol Research across NCCU and UNC (PEAR-NC)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Building Research Capacity at Institutions with Limited NIH Funding;Substance Misuse

PROJECT_TERMS: Accounting;Advocate;African American;alcohol research;alcohol use disorder;Alcohols;Applications Grants;Bachelor's Degree;Biomedical Research;Budgets;career;Collaborations;Data;Development;Doctor of Philosophy;doctoral student;Education;Enrollment;Environment;experience;Faculty;faculty research;Foundations;Funding;Future;Goals;Graduate Degree;graduate student;health disparity;Health Occupations;Hispanic;Historically Black Colleges and Universities;Human Resources;Institution;Joints;Laboratories;Laboratory Research;Lead;Leadership;Manuscripts;meetings;Mentors;Mentorship;Methodology;minority scientist;Minority-Serving Institution;Monitor;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;North Carolina;organizational structure;Outcomes Research;Participant;Pathology;Positioning Attribute;Postdoctoral Fellow;Preparation;Productivity;programs;Publications;Recording of previous events;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;response;Rewards;Schedule;Series;Services;Structure;student mentoring;student training;Students;success;synergism;Techniques;Training;Training Activity;Training and Education;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;university student;Work


NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Animals;big data management;Bioinformatics;Biological Assay;Biometry;Blood;Blood specimen;Bone Marrow;Cell Culture Techniques;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;cohort;Collaborations;Communication;cytokine;Data;data exchange;data management;Data Management Resources;data resource;Data Set;data sharing;Databases;Deposition;differential expression;digital;Epitopes;functional genomics;Gene Expression;gene network;Generations;genomic data;Gut associated lymphoid tissue;Human Resources;Immune;Immune response;Immunity;indexing;Intercept;Interleukin-15;Libraries;Link;lymph nodes;Macaca mulatta;Mediating;Molecular;Molecular Profiling;multidimensional data;nano-string;next generation sequencing;Office of Administrative Management;operation;preclinical study;Preparation;Process;Production;Program Research Project Grants;programs;public database;public repository;Publications;quality assurance;Quality Control;Research;response;RNA;Sampling;Secure;single-cell RNA sequencing;SIV;SIV Vaccines;Spleen;Standardization;Support System;synergism;Systems Biology;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Vaccination;vaccine efficacy;vaccine response;Vaccines;Viral;web-accessible;Whole Blood;Work

PROJECT_TITLE: Core C: Systems Biology Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: CHARLESTON

ORG_DEPT: SURGERY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative: The goal of this study is to determine the safety and efficacy of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) and islet co-transplantation in the prevention of surgical diabetes, and to understand the mechanisms of protection in chronic pancreatitis (CP) patients undergoing total pancreatectomy and islet transplantation (TP-IAT). If proven effective, such strategy can be used as a therapeutic option in islet transplant patients.

PI_NAMEs: WANG, HONGJUN  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Address;Adverse event;Allogenic;Animals;Area Under Curve;Autologous;Autologous Transplantation;bench to bedside;Beta Cell;Bone Marrow;bone marrow mesenchymal stem cell;C-Peptide;Cell Culture Techniques;Cell Death;Cell Survival;Cells;chemokine;chronic pancreatitis;Clinical;Clinical Trials;Complex;Constitution;Cyclic GMP;cytokine;Cytoprotection;Data;Diabetes Mellitus;Disease;DNA;Dose;effective therapy;efficacy evaluation;Engraftment;Enzyme-Linked Immunosorbent Assay;experience;Flow Cytometry;Functional disorder;Funding;Gene Expression;glycemic control;Goals;Grant;Growth Factor;HGF gene;Human;Immune response;improved;Inflammatory;Infusion procedures;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Intervention;islet;Islet Cell;Islets of Langerhans Transplantation;Measures;Mediator;Mesenchymal Stem Cells;MicroRNAs;Modeling;molecular marker;monocyte;Nature;non-diabetic;nonhuman primate;Operative Surgical Procedures;pain relief;paracrine;patient population;Patient Recruitments;Patients;post-transplant;Prevention;primary endpoint;Production;Protocols documentation;Quality of life;Randomized Controlled Clinical Trials;Research;response;Rodent;Safety;secondary endpoint;Serum;single-cell RNA sequencing;stem cell therapy;Testing;Therapeutic;Total Pancreatectomy;Transforming Growth Factor beta;Translating;transplant model;Transplant Recipients;Transplantation;United States National Institutes of Health

PROJECT_TITLE: Autologous BM-MSCs and Islet Co-transplantation to Enhance Islet Survival and Function in TP-IAT Patients

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: Public Health Relevance Crimean-Congo hemorrhagic fever (CCHF), Thunderclap headaches, and Nairobi sheep disease, are dangerous emerging human and animal diseases caused by nairoviruses that can potentially cause widespread health and economic devastation. Recently, nairoviruses have been shown to share a conserved evasion mechanism that hinders the human innate immune response. This proposal serves to investigate and leverage that mechanism through synergetic molecular, cell based and in vivo means in order to will provide information for the development of selective and broad-based anti- viral treatments.

PI_NAMEs: PEGAN, SCOTT DUSAN (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Advanced Development;Africa;Animal Diseases;Anti-viral Response;Asia;Biochemical;Catalytic Domain;Cells;Central Asia;Chiroptera;Complex;Congo;Crimean Hemorrhagic Fever;Crimean-Congo Hemorrhagic Fever Virus;Dangerousness;Data;Death Rate;Development;Disease;Distress;Economics;efficacy evaluation;Elements;emerging human pathogen;Europe;Family;Fatality rate;FDA approved;Fever;Foundations;gene product;Genes;Genome;Glycoproteins;Goals;Health;Hemorrhage;Homologous Gene;Human;human disease;human pathogen;Immune Evasion;Immune system;Immunity;immunogenicity;Immunosuppression;improved;In Vitro;in vitro activity;in vivo;innate immune pathways;Innate Immune Response;insight;Interferons;Knowledge;Measures;Methods;Molecular;Mus;Nairobi Sheep Disease;Nairobi sheep disease virus;Nairovirus;Natural Immunity;ovarian neoplasm;particle;Pathogenesis;Pathogenicity;Pathway interactions;Peptide Hydrolases;Phylogenetic Analysis;Play;Post-Translational Protein Processing;preference;pressure;prophylactic;prostration;Protease Domain;Proteins;Proteomics;public health relevance;recruit;Replicon;Reporting;response;reverse genetics;Risk;RNA Viruses;RNA-Directed RNA Polymerase;Role;Route;Russia;Severities;Sheep;Source;Species Specificity;Specificity;Structure;System;Therapeutic;Thunderclap Headaches;tick-borne virus;Time;transmission process;Ubiquitin;ubiquitin isopeptidase;Ubiquitination;United States;vaccine candidate;Vaccines;Variant;vector tick;Vertebrates;Viral;Viral Hemorrhagic Fevers;Viral Proteins;Virulence;Virulence Factors;Virus;Virus Inactivation;Virus Replication;X-Ray Crystallography;Zoonoses

PROJECT_TITLE: Origin of the innate immunity suppression caused by nairovirus' protease activity

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


PHR: Scientific Mentoring and Research Experiences (SMRE) Core – Project Narrative: Students comprise a major part of the scientific workforce for each research project. This Core provides key resources to each project to strengthen the expertise and productivity of the students by providing research experiences that equip students in complex scientific methods, team mentoring approaches, and individualized professional development.

PI_NAMEs: MARSHALL, SIMON ALEXANDER (contact)

PROJECT_TERMS: Academia;Address;alcohol research;Alcohols;career;career development;Collaborations;Communication;Complex;Dental Schools;design;Development;Disparity;Doctor of Philosophy;doctoral student;educational atmosphere;Educational process of instructing;evidence base;experience;Faculty;Fellowship;Fostering;Funding;Future;Goals;graduate student;Grant;improved;Infrastructure;Institution;Instruction;interest;Laboratories;Laboratory Research;Learning;matriculation;medical schools;member;Mentors;Mentorship;method development;Methods;Minority Groups;minority investigator;minority scientist;National Institute on Alcohol Abuse and Alcoholism;Population Heterogeneity;Postdoctoral Fellow;Productivity;programs;Research;research and development;Research Personnel;Research Project Grants;Resources;responsible research conduct;Scholarship;Science;skill acquisition;skills;Structure;student mentoring;Students;success;summer research;symposium;Techniques;Training;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Writing

PROJECT_TITLE: Scientific Mentoring and Research Experiences Core


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Chronic Pain;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury;Women's Health Research

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative  The goal of the project is to continue the laboratory’s development of a novel neuroprosthetic therapy that enhances functional recovery of voluntary movement after spinal cord injury. The hypothesis addressed in the proposal is that targeted, activity-dependent spinal stimulation will substantially increase the effectiveness of traditional and use-dependent physical rehabilitation by inducing plasticity in spared descending and spinal neural circuits. In the long-term, this therapy may prove to be an effective complement to cellular transplants or genetic reprogramming treatments that target neuronal survival, regeneration, or synaptogenesis.

PI_NAMEs: PERLMUTTER, STEVE I (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Address;Analgesics;Animals;Anti-Anxiety Agents;Anxiety;anxiety reduction;arm;Award;Behavioral;Bilateral;brain computer interface;Cell Transplantation;Cervical;Cervical spinal cord injury;Chronic;chronic pain;Clinical;clinical practice;clinical translation;Clinical Trials;Combined Modality Therapy;Complement;Contusions;COVID-19;COVID-19 pandemic;Data;Dependence;design;Development;effective therapy;Effectiveness;Electric Stimulation;Electrodes;environmental enrichment for laboratory animals;experimental study;Female;Forelimb;Foundations;Funding;Future;Genetic;Goals;Hand;Housing;human subject;improved;Intervention;laboratory development;learned behavior;male;Modeling;Motor;motor deficit;motor recovery;Movement;Muscle;Natural regeneration;Nature;Nervous System;Nervous System Disorder;neural circuit;Neural Pathways;neuroinflammation;neuromechanism;Neuronal Plasticity;neuronal survival;Neurons;neuroprosthesis;novel;Pain;Pathway interactions;Performance;Persons;Physical Rehabilitation;Physical therapy;Physiological;prevent;Psychological Factors;Quality of life;Rattus;Recovery;Recovery of Function;Rehabilitation therapy;Research;Research Activity;response;sex;Sex Differences;Spinal;Spinal cord injury;spinal pathway;Stimulus;Stress;Surface;Synaptic plasticity;synaptogenesis;Technology;Therapy Clinical Trials;therapy development;Time;Training;Translating;translation to humans;Universities;Washington

PROJECT_TITLE: Rehabilitation from Spinal Cord Injury Using Targeted, Activity-Dependent Intraspinal Stimulation

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Kidney Disease

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project narrative COVID 19 related disease is associated with an extensive cytokine storm that causes multi-organ damage. The PI has developed unique models of the cytokine storm, that will be used to develop treatment strategies for glomerular complications of this disease.

PI_NAMEs: CHUGH, SUMANT SINGH (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: ACE2;Acute;Acute Renal Failure with Renal Papillary Necrosis;adaptive immune response;Affect;Albuminuria;Allergic;Antibodies;autocrine;BALB/cJ Mouse;Biopsy;Cell membrane;cell motility;Cell Nucleus;Common Cold;Complex;COVID-19;COVID-19 cytokine storm;COVID-19 pandemic;COVID-19 pathogenesis;COVID-19 patient;COVID-19 treatment;cytokine;Cytokine Receptors;cytokine release syndrome;Cytoplasm;Data;Development;Disease;Endothelial Cells;Endothelium;experience;Feedback;Foot Process;Genetic;glomerular endothelium;Homeobox;Hospitalization;Human;IL-13Ralpha1;Immune response;In Vitro;in vivo;Inbred BALB C Mice;Individual;Inflammatory;Infusion Pumps;Injections;Injury;Integrins;Interferon Type II;Interleukin 4 Receptor;Interleukin-10;Interleukin-13;interleukin-13 receptor;Interleukin-2;Interleukin-4;Interleukin-6;Kidney;Kidney Diseases;Knockout Mice;Lesion;Membrane;Membranous Glomerulonephritis;mesangial cell;migration;Modeling;mouse model;multiorgan damage;Multiple Trauma;Mus;novel;novel therapeutics;Organ;paracrine;particle;Patients;Phosphorylation;Pilot Projects;podocyte;Population;Proteinuria;PTK2 gene;Publishing;receptor;Receptor Cell;Relapse;Renal glomerular disease;Role;SARS-CoV-2 infection;Severity of illness;Signal Transduction;Site;slit diaphragm;STAT6 gene;synergism;Therapeutic;TNF gene;TNFRSF1A gene;transcription factor;transmission process;treatment strategy;Viral;Zinc Fingers

PROJECT_TITLE: Covid 19 cytokine storm

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Substance Misuse

PHR: NARRATIVE: The current treatments for alcohol use disorders are not universally effective, so determining new therapeutic areas is of critical concern. Astrocytes, key regulators of the neuroimmune response and neurotransmission, represent a novel target by which to reduce excessive alcohol consumption. The results of the current study will explore the viability of reducing binge drinking and cognitive deficits through manipulating astrocytic regulations of neuroimmune and glutamate signaling.

PROJECT_TERMS: Addictive Behavior;Address;Affect;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol research;alcohol use disorder;Alcohols;Amygdaloid structure;anakinra;Anti-Inflammatory Agents;Area;Astrocytes;Behavior;Behavioral;binge drinking;Biological Assay;Brain Injuries;Brain-Derived Neurotrophic Factor;Cells;Cognitive deficits;combat;Consummatory Behavior;Consumption;Country;cytokine;Darkness;Dependence;designer receptors exclusively activated by designer drugs;Development;drinking;Enzyme-Linked Immunosorbent Assay;Ethanol;Ethanol dependence;Event;experimental study;extracellular;Functional disorder;Future;G Protein-Coupled Receptor Signaling;GLAST Protein;Glial Fibrillary Acidic Protein;Glutamate Transporter;glutamatergic signaling;Glutamates;Grant;health disparity;health economics;Heavy Drinking;Hippocampus;Human;Immune;Immunocompetent;Immunohistochemistry;improved;Incidence;Inflammatory;inflammatory marker;Inflammatory Response;innovation;insight;Interleukin-1;Interleukin-1 beta;Interleukin-10;Intoxication;Lead;Link;Measures;Mediating;Memory;Memory impairment;Microdialysis;Minority;Modeling;Molecular;Morphology;Mus;Neuroimmune;Neuroimmune system;Neuroimmunomodulation;neuroinflammation;Neuronal Plasticity;neurotransmission;novel;novel therapeutics;object recognition;Phenotype;Play;prevent;Procedures;Production;Quantitative Reverse Transcriptase PCR;Receptor Signaling;Regulation;Reporting;Research;response;Risk;Role;sex;Sex Differences;Signal Transduction;Site;socioeconomics;synaptic function;Testing;United States;uptake;Viral;Work

PROJECT_TITLE: Project 1: The Reciprocal Relationship between Binge Drinking and Astrocytic Signaling


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative RNA processing events are tightly regulated by RNA binding proteins. However, the mechanisms and dynamics of RNA-protein interactions are poorly understood. The proposed work will define critical mechanisms of RNA- protein interactions as well as their role in normal and disease pathways.

PI_NAMEs: DOMINGUEZ, DANIEL ISSAC (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Area;Binding;Binding Proteins;Biochemical;Cells;Cellular biology;Data;Disease;Disease Pathway;Event;Gene Expression;Genomic approach;Guanine;Literature;Mediating;Pathogenicity;Pathway interactions;programs;protein folding;protein protein interaction;Proteins;Regulation;Regulator Genes;Research;RNA;RNA Binding;RNA Folding;RNA Processing;RNA Recognition Motif;RNA-Binding Proteins;RNA-Protein Interaction;Role;Structure;Work

PROJECT_TITLE: Protein Disorder as a Mechanism of RNA Binding and Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Why do organisms follow certain evolutionary trajectories when many are possible? The research program proposed here will identify the genetic factors and fitness effects that determine evolutionary repeatability in natural populations. The results are relevant to the fields of public health, conservation biology, and agricultural breeding, because they will help understand the probability of adaptation in target populations facing new selective challenges and parameterization of predictive models.

PI_NAMEs: RENNISON, DIANA JESSIE (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TITLE: Understanding predictability of evolutionary trajectories

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Substance Misuse

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as an understanding of those molecular pathways that modify sensitivity to prenatal alcohol exposure-induced birth defects is expected in the long-term to inform clinical practice and ultimately reduce the incidence and severity of Fetal Alcohol Spectrum Disorders (FASD). This objective will be met by applying two innovative and complementary approaches to assess in cell and animal models if novel genes or chemicals modulate the deficits elicited by ethanol exposure. Thus, the proposed research is relevant to the parts of NIH/NIAAA’s mission that pertains to characterizing biological mechanisms underlying FASD, identifying biomarkers of prenatal alcohol exposure, and ultimately will reveal fundamental and novel insights into the mechanism of ethanol-induced birth defects.

PI_NAMEs: WILLIAMS, KEVIN PETER (contact)

PROJECT_TERMS: Acetylcysteine;Address;Agonist;alcohol effect;alcohol exposure;alcohol research;alcohol sensitivity;Alcohols;Animal Model;Applications Grants;Attenuated;Behavioral;Behavioral Model;beta Actin;Biological;Biological Models;biomarker identification;brain abnormalities;Candidate Disease Gene;Cell Line;Cell model;Cells;Chemicals;Chick;Cilia;clinical practice;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive deficits;Congenital Abnormality;Craniofacial Abnormalities;Data;Defect;Development;differential expression;Digit structure;disease model;Drug Screening;Embryo;Embryonic Development;established cell line;Ethanol;experimental study;Faculty;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Development;Fishes;Fostering;Foundations;Future;gene environment interaction;gene interaction;Gene Modified;Genes;Genetic;Genetically Engineered Mouse;Goals;Growth;high throughput screening;Human;In Vitro;in vitro Model;in vivo;in vivo Model;Incidence;innovation;insight;Intervention;Knock-out;Knockout Mice;Libraries;Limb Bud;Limb Development;Limb structure;Literature;Mentorship;Mission;Modeling;Molecular;Molecular Target;Morphology;mouse genetics;mouse model;Mus;National Institute on Alcohol Abuse and Alcoholism;novel;Pathway interactions;Pectoral;pharmacologic;postnatal;Predisposition;prenatal;Public Health;Research;Research Personnel;Research Project Grants;Research Proposals;Resistance;Role;Scientist;screening;Series;Severities;SHH gene;Signal Pathway;Signal Transduction;skeletal;small hairpin RNA;Small Interfering RNA;small molecule;small molecule libraries;smoothened signaling pathway;Sonic Hedgehog Pathway;Specific qualifier value;Stains;Technology;teratogenesis;Teratogenic effects;Teratogens;Testing;Tissues;transcriptome sequencing;Transfection;Transgenic Organisms;Tretinoin;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Visual;Zebrafish

PROJECT_TITLE: Project 2: Prenatal Alcohol Exposure (PAE) and Fetal Alcohol Spectrum Disorder (FASD)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse;Women's Health Research

PHR: PROJECT NARRATIVE This project aims to investigate the effects of alcohol on mammary stem cell deregulation and genomic instability in mammary tumor initiation and development. The role of the alcohol metabolite, acetaldehyde, in this process and the consequent molecular changes will be studied using transgenic animal models. Results from this project are expected to advance our understanding of the mechanisms of alcohol-associated breast cancer risk.

PI_NAMEs: YANG, XIAOHE  (contact)

PROJECT_TERMS: Acetaldehyde;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol prevention;alcohol research;alcohol response;Alcohols;Animal Model;Animals;beta catenin;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Risk Factor;Breast Carcinogenesis;Breast Epithelial Cells;Cancer cell line;Cancer Etiology;cancer initiation;cancer stem cell;Cancerous;carcinogenesis;CD44 gene;Cell Line;Cell Separation;cell transformation;cell type;Cells;cellular targeting;chromosomal location;Chromosome abnormality;Chromosomes;clinically relevant;comparative genomic hybridization;Data;Detection;Development;diagnostic biomarker;Diet;DNA Damage;DNA Repair;DNA Repair Disorder;Early Diagnosis;ERBB2 gene;experience;Female;Flow Cytometry;Frequencies;Gene Dosage;Gene Mutation;Genetic;Genome;Genomic Instability;Genomics;genotoxicity;Hematopoietic stem cells;Histopathology;Human;Impairment;in vitro Model;in vivo;in vivo Model;Injury;insight;Invaded;ITGB3 gene;Karyotype determination procedure;Knock-out;Lesion;Liquid substance;Liver;Malignant - descriptor;Malignant Breast Neoplasm;mammary;Mammary Neoplasms;Mammary Tumorigenesis;Mammospheres;Mediating;Mediator;Methodology;migration;Modeling;Molecular;Mouse Mammary Tumor Virus;mouse model;Mus;Mutate;Mutation;Neoplasm Metastasis;neoplastic cell;novel diagnostics;Pathogenesis;Pathway interactions;Play;Population;premalignant;Premalignant Cell;Prevention;Process;Production;Recurrence;Reporting;Risk;Role;self-renewal;Signal Transduction;STAT3 gene;stem;stem cell expansion;Stem Cell Research;Stem cell transplant;stem cells;stemness;Testing;therapeutic target;three dimensional cell culture;tissue injury;tissue stem cells;Tissues;TNFSF11 gene;tool;Toxic effect;TP53 gene;Transgenic Animals;tumor;tumor initiation;Tumor Suppressor Proteins;tumorigenesis;Up-Regulation

PROJECT_TITLE: Project 3: Alcohol-Associated Toxicity and Genomic Instability of Mammary Stem Cells


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Created in response to the NIH CTSA program, the Georgia Clinical & Translational Science Alliance (Georgia CTSA) supports high quality collaborative translational science locally, regionally, and nationally; fosters scientific and operational innovation to improve the efficiency and effectiveness of clinical and translational research; and creates, provides, and disseminates domain-specific translational science training and workforce development.

PI_NAMEs: GARCIA, ANDRES J;OFILI, ELIZABETH O.;PHILLIPS, BRADLEY GEORGE;TAYLOR, WILLIAM ROBERT (contact)

PROGRAM_OFFICER_NAME: NAGEL, JOAN DAVIS

PROJECT_TERMS: Acceleration;Behavioral Sciences;career development;Centers for Disease Control and Prevention (U.S.);certificate program;Child health care;Clinical;Clinical effectiveness;Clinical Research;Clinical Sciences;clinical translation;Collaborations;college;Communities;Community Physician;Country;Diabetes Mellitus;Disease;Disparity;Education;Educational Curriculum;Effectiveness;Environment;equity, diversity, and inclusion;Ethics;experience;Fostering;Goals;Health;health care availability;health care disparity;health equity;health equity promotion;Health system;Healthcare;Hypertension;improved;Individual;Informatics;Information Technology;innovation;insight;Institution;Investments;Knowledge;life span;Master of Science;Medical center;Methods;minority communities;Morbidity - disease rate;Morehouse School of Medicine;mortality;Obesity;operation;Outcome;Participant;Patients;Pharmacy facility;Pilot Projects;poor communities;Population;Primates;Process;programs;Publications;Research;Research Methodology;Research Personnel;Research Training;response;Rural Community;Science;Site;skills;social science research;Structure;Students;success;synergism;System;technological innovation;Technology;TNFSF15 gene;tool;Training;Training Activity;Translational Research;Translations;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Urban Community;Workforce Development


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Acute;Address;Bioinformatics;Blood;CD8-Positive T-Lymphocytes;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;cohort;Computer Analysis;Coupled;Cytomegalovirus;Data Set;functional genomics;Gene Expression;gene network;Genes;genomic data;Goals;Gut associated lymphoid tissue;HIV Antigens;HIV vaccine;Human;Immune;immune activation;Immune response;Immune signaling;Immunity;In Vitro;in vivo;in vivo evaluation;Infection;Inflammatory;Intercept;Interferons;Interleukin-15;Knowledge;Link;lymph nodes;Lymphoid Tissue;Macaca mulatta;Mediating;Mitogen-Activated Protein Kinases;Modeling;Molecular;monocyte;Mucous Membrane;nano-string;Pathogenicity;Pathway interactions;Peripheral Blood Mononuclear Cell;Phenotype;predictive marker;predictive signature;Production;programs;Research Design;response;Rhesus;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;SIV;SIV Vaccines;Statistical Data Interpretation;success;System;Systems Biology;T-Lymphocyte;Tissues;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Translating;treatment response;Vaccinated;Vaccination;vaccine efficacy;vaccine response;Vaccines;vaccinology;vector;vector-based vaccine;Viral;Viral Antigens;Virus;Virus Diseases;Whole Blood;Work

PROJECT_TITLE: Project 2: Systems biology analyses of RHCMV/SIV and IL-15 mechanisms of immune programming


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Patient Safety;Prescription Drug Misuse;Substance Misuse

PHR: PROJECT NARRATIVE Alcohol withdrawal syndrome is a common, potentially fatal condition in hospitalized patients with two dominant therapies (benzodiazepines and phenobarbital), but no rigorous evidence to inform best practice. This K23 award will investigate how and why providers choose benzodiazepines or phenobarbital for management of inpatient alcohol withdrawal syndrome and the risk of adverse events associated with either treatment in different groups of hospitalized patients. This knowledge will be used to design and pilot an embedded pragmatic clinical trial to identify the safest first-line therapy for inpatient alcohol withdrawal syndrome: benzodiazepines or phenobarbital.

PI_NAMEs: STEEL, TESSA LYNNE (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Academic Medical Centers;advanced analytics;Adverse effects;Adverse event;adverse event risk;Affect;Age;Agitation;alcohol abuse therapy;alcohol use disorder;Alcohol withdrawal syndrome;arm;Automobile Driving;Belief;Benzodiazepines;career;career development;Caring;Clinical;Clinical Data;Community Hospitals;comparative safety;Conduct Clinical Trials;County;Critical Care;Dangerousness;Data;Delirium;design;Disease;Dose;electronic health data;Electronic Health Record;Equipoise;Feedback;Foundations;Goals;Group Hospitalization;Guidelines;Health Personnel;Health system;high risk;hospital care;Hospitalization;Hospitals;Impaired cognition;implementation framework;improved;improved outcome;innovation;Inpatients;intervention refinement;Interview;Investigation;K-Series Research Career Programs;Knowledge;Measures;Mechanical ventilation;Medical center;Medical emergency;medical specialties;medication safety;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;mortality;multidisciplinary;Myocardial Infarction;patient subsets;Patients;Pharmaceutical Preparations;Phenobarbital;Physical Restraint;Physicians;Practice Guidelines;Pragmatic clinical trial;pragmatic randomized trial;pragmatic trial;Procedures;Process;Provider;provider behavior;provider factors;Public Health;Qualitative Research;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Research;Research Methodology;Research Personnel;response;Retrospective cohort;Risk;Safety;safety net;Scientist;Severity of illness;side effect;Steel;Structure;Testing;Theoretical Domains framework;Training;training opportunity;trauma centers;treatment effect;Treatment Protocols;United States;Universities;Variant;Ventilatory Depression;Washington;Work

PROJECT_TITLE: Improving the Safety of Treatment for Hospitalized Patients with Alcohol Withdrawal Syndrome

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative: 3 sentences P. vivax is an emerging pathogen in sub-Saharan Africa, but control efforts remain focused on P. falciparum. Here, we propose to 1) quantify the clinical burden and associated risk factors of P. vivax for the first time in north-western Kenya, 2) estimate rate of underlying P. vivax infections in a P. falciparum and P. vivax co- endemic setting, and 3) implicate local vectors in P. vivax transmission with a special emphasis on surveillance for the invasive vector An. stephensi, thereby informing the potential for P. vivax to spread throughout Kenya. Findings from this study will not only help strengthen the core surveillance capacity in north-western Kenya, but will also generate evidence to guide Kenya’s National Malaria Control Programme and those of similar regions of sub-Saharan Africa as they confront the possibility of growing endemic P. vivax transmission fueled by an emerging vector species.

PI_NAMEs: PRUDHOMMEOMEARA, WENDY  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Acceleration;Address;Africa;Africa South of the Sahara;African;Aftercare;Anopheles Genus;Anti-malarials;Antigens;Area;arid land;blood group;Blood typing procedure;Case Management;Case Study;Classification;Clinical;Collaborations;Country;County;Coupled;Culicidae;Detection;Diagnostic;disorder control;Documentation;Ecology;emerging pathogen;Erythrocytes;Ethiopia;evidence base;Exclusion;fighting;Foundations;Future;Genetic;Goals;Health;Health care facility;high risk;Home;Horns;Household;Human;Individual;Infection;infection rate;infectious disease model;Invaded;Kenya;Larva;Learning;Liver;Malaria;Measures;Modeling;Molecular;Morbidity - disease rate;mortality;multidisciplinary;neglect;Parasites;patient screening;Patients;Phase;Plasmodium falciparum;Plasmodium vivax;Population;Prevalence;programs;Relapse;Reporting;Reproducibility;Rest;Risk Factors;Testing;Time;transmission process;treatment strategy;Universities;vector;Work

PROJECT_TITLE: Quantifying the dual threat of Plasmodium vivax and Anopheles stephensi in a P. falciparum endemic pre-elimination setting in sub-Saharan Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-U(02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emergency Care;Health Services;Hematology;Infectious Diseases;Kidney Disease;Patient Safety;Pediatric;Sepsis

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative Septic shock is acute cardiovascular failure due to an infection that affects tens of thousands of children each year. Although crystalloid fluid resuscitation is the cornerstone of initial resuscitation, there is no definitive evidence for the most effective and safest type of crystalloid fluid in children. The objective of this large, pragmatic, randomized study is to test the comparative effectiveness of the two most common types of crystalloid to improve clinical outcomes in children treated for septic shock.

PI_NAMEs: BALAMUTH, FRANCES B (contact);WEISS, SCOTT L

PROGRAM_OFFICER_NAME: TAMBURRO, ROBERT F

PROJECT_TERMS: Accident and Emergency department;Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Adherence;Admission activity;Adult;Adverse event;Affect;Agreement;Anions;Antibiotics;Applied Research;Australia;Biological;Blood Coagulation Disorders;Buffers;Canada;Cardiovascular system;Caring;Centers for Disease Control and Prevention (U.S.);Cessation of life;Child;Childhood;Chlorides;Clinical;clinical practice;Collaborations;Companions;comparative effectiveness;comparative effectiveness trial;cost;cost efficient;Critical Care;Critical Illness;crystalloid;Data;Dialysis procedure;Eligibility Determination;Emergency Care;Emergency Department Physician;Emergency research;Enrollment;Equipoise;Ethics;Event;Failure;Feasibility Studies;Fluid Balance;Follow-Up Studies;Frequencies;Functional disorder;Funding;Guidelines;Hospital Mortality;Hospitalization;Hospitals;Hour;Immune response;Immune System Diseases;improved;Individual;Infection;Informed Consent;innovation;International;Isotonic Exercise;Kidney;kidney dysfunction;Knowledge;Lactated Ringer's Solution;Length of Stay;Life;Liquid substance;Literature;Maintenance;Medical emergency;Monitor;mortality;Multicenter Trials;Multiple Organ Failure;National Center for Advancing Translational Sciences;New Zealand;Normal saline;open label;Organ;Outcome;patient oriented;Patients;pediatric emergency;pediatric sepsis;Personal Communication;Physicians;Physiological;Pilot Projects;Population;pragmatic randomized trial;pragmatic trial;preference;preservation;primary outcome;prospective;Provider;Public Health;Randomized;randomized trial;Registries;relative effectiveness;Relative Risks;Renal Blood Flow;Reporting;Research Design;Resuscitation;Risk Reduction;Safety;Saline;Sample Size;secondary outcome;Sepsis;Septic Shock;Shock;Site;Specific qualifier value;Surveys;Testing;Therapeutic;treatment optimization;United States;World Health Organization

PROJECT_TITLE: PRagMatic Pediatric Trial of Balanced versus NOrmaL Saline FlUid in Sepsis (PRoMPT BOLUS)

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Hypertension;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: We will test the novel hypothesis that increased blood pressure variability, as opposed to overt hypertension, impairs neurovascular function. Specifically, we will show that exacerbated mechanostimulation-driven calcium overload at the neurovascular unit cause cognitive decline.

PI_NAMEs: FILOSA, JESSICA A (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acute;Address;Angiotensin II;arteriole;Astrocytes;Blood Pressure;blood pressure elevation;blood pressure variability;Blood Vessels;Brain;Calcium;Cardiovascular system;Cations;Cell Physiology;cellular targeting;cerebral hypoperfusion;Cerebrovascular Circulation;Cerebrum;Chronic;cognitive function;Conscious;constriction;Coupled;Data;Dementia;Development;Diameter;Diastolic blood pressure;early onset;Endothelial Cells;Erythrocytes;Event;Functional disorder;Genetic;Gliosis;Heart Rate;Homeostasis;Hypertension;hypoperfusion;Image;Immunohistochemistry;Impaired cognition;Impairment;Implant;in vivo;Inflammation;Inflammatory;Infusion procedures;Infusion Pumps;innovation;Lasers;Link;loss of function;Measurement;Measures;Mediating;Microscopic;Modeling;Molecular;Molecular Target;Monitor;mouse model;Mus;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;neurovascular;neurovascular coupling;neurovascular unit;novel;Nutrient;Organ;Oxygen;parenchymal arterioles;Pathway interactions;Perfusion;Permeability;pharmacologic;Phenotype;pressure;Process;Reflex action;response;Risk Factors;Saline;Sensory;single-cell RNA sequencing;Slice;subcutaneous;Systemic blood pressure;Technology;Telemetry;Testing;tool;two photon microscopy;two-photon;vascular cognitive impairment and dementia;Viral

PROJECT_TITLE: The impact of blood pressure variability on neurovascular function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-Z(91)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: We have recently demonstrated that aberrant activation of CHMP7 and the ESCRT-III nuclear surveillance pathway is an early pathogenic event that initiates NPC injury and impacts downstream TDP-43 dysfunction and localization in sporadic ALS and C9orf72 ALS/FTD. However, the molecular mechanisms that facilitate nuclear accumulation of CHMP7 and CHMP7 mediated NPC injury in ALS/FTD human neurons remain unknown. This proposal will test the hypothesis that cell biological events and protein interactions that specifically regulate CHMP7/ESCRT-III mediated NPC homeostasis in human neurons are pathologically impaired in ALS/FTD.

PI_NAMEs: COYNE, ALYSSA  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: age related neurodegeneration;Amyotrophic Lateral Sclerosis;Autopsy;Biochemical;Biological;C9ORF72;Cell division;Cell Physiology;cell type;Cells;confocal imaging;Cytoplasm;Data;Defect;Disease;Environment;Event;Excision;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Gene Expression;Genetic;Genome;Health;Homeostasis;Human;imaging modality;Immunoprecipitation;Impairment;Individual;Induced pluripotent stem cell derived neurons;Injury;insight;knock-down;Libraries;live cell imaging;Maintenance;Mammalian Cell;Mediating;Membrane;Membrane Proteins;Molecular;mutant;Mutate;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;Nuclear;Nuclear Envelope;Nuclear Export;Nuclear Inner Membrane;Nuclear Pore Complex;Nuclear Pore Complex Proteins;Nuclear Protein;nucleocytoplasmic transport;Pathogenicity;Pathologic;Pathway interactions;Patients;Physiological;Plasmids;Point Mutation;Process;protein complex;protein degradation;Protein Import;protein protein interaction;protein TDP-43;Proteins;receptor;recruit;RNA-Binding Proteins;Role;seal;Series;Small Interfering RNA;sporadic amyotrophic lateral sclerosis;Structure;superresolution imaging;Techniques;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;Tissues;ultra high resolution;Variant;Yeasts

PROJECT_TITLE: Mechanisms of impaired ESCRT-III nuclear surveillance in ALS/FTD

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Maternal Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Continued high rates of neonatal, infant, child, and maternal mortality and severe morbidities require a concerted effort of effective domestic and international partners to improve healthcare in resource-limited settings. This grant application will allow the top performing UAB-Zambia team participation in the Global Network to continue to lead transformational research that changes international guidelines for maternal and child care and reduce adverse pregnancy and child outcomes.

PI_NAMEs: CARLO FONT, WALDEMAR A. (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Alabama;Applications Grants;Australia;Azithromycin;Birth Weight;Brain;Caring;Cesarean section;Characteristics;Child;Child Care;Child Health;Child health care;Child Mortality;Clinical Research;clinical trial protocol;Clinical Trials;Cohort Studies;Collaborations;Data Analyses;Databases;design;Discipline of obstetrics;Education;Enrollment;Ensure;Feasibility Studies;feasibility trial;follow-up;Forcep;Geography;Goals;Government;Grant;Guidelines;Health Policy;Healthcare;Healthcare Systems;Implementation readiness;improved;Infant;infant morbidity/mortality;Infant Mortality;innovation;instrument;International;Intervention;intrapartum;Knowledge;Lead;Leadership;machine learning model;Maternal Health Services;Maternal Mortality;maternal outcome;member;Modeling;Morbidity - disease rate;Mothers;multidisciplinary;National Institute of Child Health and Human Development;Neonatal;neonatal health;neonatal hypoxic-ischemic brain injury;Neonatal Mortality;neonatal outcome;neuroprotection;Observational Study;Outcome;Pediatrics;Peer Review;Performance;performance site;Perinatal Care;Perinatal mortality demographics;pilot trial;predictive modeling;Pregnancy;prevent;Principal Investigator;Program Sustainability;prophylactic;prospective;Protocols documentation;Public Health;Publications;Qualifying;randomized trial;Randomized, Controlled Trials;recruit;Registries;Reporting;Reproducibility;Research;Research Personnel;Research Priority;Resource-limited setting;Rural;scale up;sildenafil;Site;Specialist;success;Targeted Research;Teaching Hospitals;Techniques;Testing;Training;U-Series Cooperative Agreements;Universities;Vacuum;Woman;Work;Zambia

PROJECT_TITLE: Interventions to Reduce Infant Mortality and Morbidity in Low Resource Settings


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: FORT COLLINS

ORG_DEPT: NUTRITION

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: PROJECT NARRATIVE American Indian and Alaska Native (AI/AN) adults are almost twice as likely to have type 2 diabetes (T2D) than non-Hispanic white adults. Healthy nutrition habits are a cornerstone to effective diabetes self-management; however, barriers to healthful eating, such as lack of access to culturally-responsive diabetes nutrition education, lack of access to fresh food, or inability to afford healthy food (known as food insecurity), are common among AI/ANs with T2D. The proposed research is relevant to public health because the development of effective interventions to target AI/ANs with T2D who experience food insecurity is fundamental in reducing disproportionate diabetes health disparities among AI/AN communities.

PI_NAMEs: STOTZ, SARAH A (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Address;Adult;Alaska Native;Alaska Native population;American Indian Population;American Indians;Area;Behavior;Beverages;Biometry;Blood Glucose;Blood Pressure;Body mass index;Body Weight;career;career development;Caring;Cities;Clinic;Clinical;Clinical Trials;Colorado;Communities;Data;Data Analyses;Data Collection;Data Set;design;Development;diabetes education;diabetes management;Diabetes Mellitus;diabetes self-management;Diabetic Diet;Dietary Intervention;Disparity;Eating;Educational Activities;Educational Curriculum;Educational workshop;effective intervention;effectiveness study;effectiveness trial;Environment;Environmental Pollution;Evidence based intervention;experience;Farm;farmer;fast food;Food;Food Access;food insecurity;food security;Foundations;Funding;Glycosylated hemoglobin A;Goals;good diet;Habits;Health;health disparity;Health Food;Healthcare;Healthy Eating;Household;improved;Intake;International;Intervention;intervention participants;Intervention Studies;Knowledge;learning strategy;Life;Marketing;Measures;Medical;Mentored Research Scientist Development Award;Mentors;Methodology;Methods;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;nutrition;nutrition education;Oklahoma;Outcome;Participant;Pilot Projects;pilot test;portion control;Positioning Attribute;Poverty;pragmatic study;pragmatic trial;Problem Solving;Process;programs;Public Health;Randomized;Research;Research Design;Research Methodology;Research Personnel;Rural Community;saturated fat;Science;secondary analysis;Secure;Self Efficacy;Services;Site;skills;social health determinants;Sodium;Strategic Planning;Surveys;symposium;Testing;therapy design;Training;Transportation;Tribes;Universities;urban area;urban Native American;Waiting Lists;Water;Work

PROJECT_TITLE: Exploring Food Insecurity and Pilot Testing a Diabetes Nutrition Education Program and Healthy Food Access Service for American Indian and Alaska Native Adults with Type 2 Diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: Project Narrative Acute Myeloid Leukemia (AML) is the deadliest leukemia, and though treatment with allogeneic stem cell transplantation (alloSCT) and other immunotherapies is often beneficial, over 50% of AML patients eventually relapse. Little is known about what the drivers of the graft versus host and graft versus leukemia effects of alloSCT in this context. We hypothesize that minor histocompatibility antigens (mHAs) are a key driver of the effects of alloSCT for AML, and seek to identify novel mHAs and assess mHA-specific T cells in post-alloSCT relapse.

PI_NAMEs: OLSEN, KELLY SHEA (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Ablation;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Alleles;Allogenic;Antigen Presentation;Antigen Targeting;antigen-specific T cells;Bioinformatics;Biology;Blood;Bone Marrow;career;Caring;Caucasians;Cell Line;Cell surface;Cells;Cessation of life;Clinical;Clinical assessments;common treatment;curative treatments;cytokine;Data Set;Disease;Disease-Free Survival;Donor person;Ethnic Origin;Ethnic Population;exhaust;exhaustion;experience;Flow Cytometry;Frequencies;Funding;Future;Genetic Polymorphism;Goals;graft vs host disease;graft vs leukemia effect;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic stem cells;hematopoietic tissue;Human;Immune system;Immunobiology;Immunologics;Immunology;Immunotherapy;improved;Individual;Inflammatory;Knowledge;large datasets;leukemia;leukemia relapse;Leukocytes;Life;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Methods;Minor Histocompatibility Antigens;novel;Oncology;Outcome;Patient-Focused Outcomes;Patients;Peptides;Phenotype;Physicians;Population;Population Study;Prevalence;Production;Prognosis;Proteins;reconstitution;Relapse;relapse risk;Research;response;Role;Sampling;Scientist;side effect;Stains;statistical learning;Stem cell transplant;success;T cell response;T-Lymphocyte;targeted treatment;therapeutic target;Time;Tissues;Training;Transplant Recipients;tumor immunology;Work

PROJECT_TITLE: Minor Histocompatibility Antigen T Cell Targeting in Acute Myeloid Leukemia


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Chromatin-associated RNAs regulate gene expression and cell fate decisions during embryonic development. R-loops—nuclear structures that arise from hybridization of nascent RNA transcripts to their DNA templates— have important roles in regulation of chromatin structure, but also can contribute to genome instability. We will dissect the mechanisms by which R-loops carry out their regulatory functions and contribute to developmental cell fate.

PI_NAMEs: FAZZIO, THOMAS G. (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Affect;Atlases;Benchmarking;Binding;Binding Proteins;Binding Sites;Biogenesis;Biological;CCCTC-binding factor;Cell Nucleolus;Cell Nucleus;Cell Proliferation;cell type;Cells;Chromatin;Chromatin Remodeling Factor;Chromatin Structure;Chromosomes;Code;cohesin;Data;Defect;Deposition;Development;developmental disease;Developmental Gene;DNA;Embryo;Embryonic Development;Epigenetic Process;epigenetic profiling;epigenome;epigenomic profiling;ES Cell Line;experimental study;Funding;gastrulation;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic Transcription;Genome;Genomic Instability;genomic profiling;genomic tools;Genotoxic Stress;Germ Layers;Heterogeneity;histone modification;Hybrids;Impairment;in vivo;Location;Maintenance;Maps;Mediating;Mediator;Meditation;Methods;Methylation;Methyltransferase;Modeling;Mouse Embryonic Stem Cells;Mus;novel;Nuclear RNA;Nuclear Structure;Pathway interactions;Play;Pluripotent Stem Cells;Process;protein function;Proteins;recruit;Regulation;Research;Ribosomal DNA;Ribosomes;RNA;RNA Processing;RNA Splicing;Role;single cell genomics;Specific qualifier value;stem cell differentiation;Structure;Testing;tool;Transcript;Transcription Elongation;transcription factor;Transcription Initiation;transcriptome sequencing;Untranslated RNA

PROJECT_TITLE: Epigenetic control of developmental gene regulation

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE It has the potential to develop the first therapy to combat anti-VEGF resistance of CNV by inhibiting arteriolar CNV, and significantly improve current anti-VEGF therapies for a broad spectrum of patients. Because anti- VEGF therapy is the mainstay treatment for ocular vascular diseases including CNV, diabetic retinopathy, and retinal vein occlusion, this project will have broad impact on the field of ocular angiogenic diseases.

PI_NAMEs: FU, YINGBIN  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Affect;Age related macular degeneration;Alternative Therapies;Angiogenic Factor;Apolipoprotein A-I;arteriole;Binding;Binding Proteins;Blindness;Blood capillaries;Blood Vessels;Caliber;Cholesterol;Choroidal Neovascularization;Clinical;combat;combination gene therapy;Combined Modality Therapy;comparative efficacy;cytokine;Dependovirus;design;Diabetic Retinopathy;Disease;efficacy evaluation;Elderly;Endothelial Cells;Feedback;Fibroblast Growth Factor;Gene Expression Regulation;High Density Lipoproteins;Hyperactivity;improved;Inflammation;Inflammatory;intravitreal injection;KDR gene;Knock-out;Lasers;loss of function;Macrophage;matrigel;Membrane Microdomains;middle age;Modeling;mouse model;Mus;mutant;old mice;Outcome;overexpression;Oxidative Stress;Pathologic Neovascularization;Patients;Play;Protein Overexpression;Quality of life;recruit;Regulation;Resistance;Retina;Retinal Vein Occlusion;Risk;Role;Safety;Signal Transduction;Site;Structure;subretinal injection;Testing;Therapeutic;TLR4 gene;Treatment Efficacy;Treatment Factor;Vascular Diseases;Vascular Endothelial Growth Factors;Vascular Permeabilities

PROJECT_TITLE: Mechanistic study and therapeutic application of AIBP in AMD

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Depression;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_NAME: FRIENDS RESEARCH INSTITUTE, INC.

PHR: PROJECT NARRATIVE  The purpose of the proposed study is to adapt the Ending Self-Stigma intervention for people living with HIV (PLWH) with opioid use disorder (OUD) and/or cocaine use disorder (CUD). The intervention will be modified through an iterative process of qualitative interviews with service delivery key informants and PLWH with OUD and/or CUD. There will also be two pilot tests before being tested in a small (N = 70) randomized clinical trial (RCT). Using data from the RCT, bivariate analyses will be conducted and path models will be fit to examine the effect of the intervention on proximal outcomes (internalized substance use and HIV stigmas, depressive symptoms, anxiety and stigma stress) and distal outcomes (antiretroviral therapy adherence, viral load suppression, self-reported substance use and urine toxicology screen for substances). The proposed research has the potential to reduce internalized stigma among PLWH with OUD and/or CUD and impact HIV outcomes and substance use cessation.

PI_NAMEs: FLETCHER, JESSE BRADFORD (contact);LUCKSTED, ALICIA

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: absorption;acceptability and feasibility;Address;Adult;African American;antiretroviral therapy;Anxiety;Belief;Bisexual;Clinical;Cocaine use disorder;Cognitive Therapy;coping;Data;Depressed mood;depressive symptoms;design;Discrimination;Distal;Effectiveness;Ethnic Origin;evidence base;Evidence based intervention;Exercise;experience;Face;Feedback;follow-up;Foundations;functional improvement;Funding;Future;Gays;Health;HIV;HIV Seropositivity;improved;Individual;informant;innovation;internalized stigma;Intervention;intervention delivery;intervention effect;Interview;Learning;Learning Skill;Literature;Lived experience;Low income;Manuals;marginalization;marginalized population;Measures;men;Mental Depression;Mental Health;Meta-Analysis;Modeling;opioid use disorder;Outcome;Pamphlets;Participant;Patient Self-Report;perceived stress;Persons;physical conditioning;Pilot Projects;pilot test;Population;Prejudice;Preparation;Process;Public Health;Publishing;Race;randomized, clinical trials;Reporting;Research;Sampling;Self Concept;service delivery;Sex Orientation;skills;social cognitive theory;Social Identification;social stigma;Stereotyping;Stigmatization;Stress;study population;substance use;Substance Use Disorder;Suggestion;Target Populations;Testing;therapy adherence;Toxic effect;Toxicology;treatment as usual;Urine;Viral Load result;virtual;virtual delivery;virtual group;virtual intervention;web platform

PROJECT_TITLE: Intervention to Reduce Internalized Stigma (IRIS) among People Living with HIV who use Substances

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Lung;Lung Cancer

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative We will leverage our expertise and resources to: i) Determine the role of the IL-8/CXCR1/CXCR2 pathway, metabolic suppression and immunity in lung/colorectal cancer; ii) Analyze IL-8 and neutrophils/NETs as negative immunomodulatory factors; and iii) Analyze the role of IL-8 pathway and myeloid cells during cancer progression.

PI_NAMEs: SCHALPER, KURT A (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Acceleration;Animal Model;anti-tumor immune response;Area;Biological Markers;Biological Models;Blocking Antibodies;cancer immunobiology;cancer immunotherapy;carcinogenesis;Cells;Clinic;Clinical;Clinical Trials;clinically significant;Colorectal;Colorectal Cancer;colorectal cancer progression;CTLA4 gene;Cytometry;Dependence;deprivation;design;Development;Diagnostic;Drug or chemical Tissue Distribution;Effector Cell;effector T cell;Event;Exposure to;extracellular;Genes;Glucose;Glycolysis;Human;Hypoxia;IL8 gene;IL8RA gene;IL8RB gene;Image;Immune;immune checkpoint blockers;Immune Evasion;Immunity;immunoregulation;Immunotherapeutic agent;Immunotherapy;Ischemia;Large Intestine Carcinoma;Lung;Lung Carcinoma;Malignant neoplasm of lung;Malignant Neoplasms;malignant phenotype;Maps;Measures;Mediating;Metabolic;Modality;Molecular;mortality;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;neutrophil;novel marker;novel therapeutics;optimal treatments;Outcome;Oxygen;Pathology;Pathway interactions;Patient Selection;Patients;PD-1/PD-L1;programmed cell death protein 1;Property;receptor;Refractory;Resistance;Resources;response;rodent genome;Role;sample collection;T cell response;T-Lymphocyte;Therapeutic;Therapeutic Intervention;therapy resistant;Translational Research;tumor;tumor microenvironment;tumor progression;Tumor stage;tumor-immune system interactions;Work

PROJECT_TITLE: Understanding the role and clinical potential of dominant immune suppressive myeloid-cell responses in human cancer

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Social Determinants of Health

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Public Impact: Several serious mental health issues such as feeling depressed and using drugs involve problems with the processing and seeking of rewarding experiences. In addition, several of these emotional health problems are more common in individuals with a history of adversity early in life, and differ in men and women. Using experimental models, we discovered a new component of the brain machinery which is responsible for reward behaviors and have found the function of this component (projection) is influenced by early life adversity in a sex dependent way. Here we will use powerful methods in genetically-engineered mice to characterize the roles of this novel brain pathway in both males and females and uncover how it contributes to the mechanisms by which early-life adversity may promote mental health problems such as depression and substance use.

PI_NAMEs: BARAM, TALLIE Z.  (contact);CHEN, YUNCAI ;MAHLER, STEPHEN VINCENT

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Adult;Affect;Amygdaloid structure;Anhedonia;antagonist;Behavior;biocytin;Brain;brain pathway;cell type;Cells;Consumption;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;Data;Depressed mood;Drug usage;early life adversity;Emotional;Equipment;experience;Experimental Models;Exposure to;Feeling;Female;Fiber;Food;gamma-Aminobutyric Acid;Genetic;Genetically Engineered Mouse;Health;Home;Human;human subject;immunocytochemistry;Individual;insight;Life;Major Depressive Disorder;male;Mediating;men;Mental Depression;Mental disorders;Mental Health;Mental health promotion;Methods;Modeling;Molecular;Motivation;Mus;Neurons;Neuropeptides;neurotransmission;novel;Nucleus Accumbens;open source;operation;optogenetics;Pathway interactions;Phenotype;pleasure;Rattus;Receptor Activation;Recording of previous events;Rewards;Rodent;Role;sex;Signal Transduction;Stress;substance use;Technology;temporal measurement;Testing;Transgenic Mice;Woman

PROJECT_TITLE: On circuit mechanisms of reward behaviors  after early-life adversity

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: LOUISVILLE

ORG_NAME: LOUISVILLE VA MEDICAL MEDICAL CENTER

ORG_STATE: KY

PHR: The most frequently diagnosed diseases among VA patients are inflammation related diseases including brain inflammation related diseases, obesity, rheumatoid arthritis, and colon cancer. Determining the precise mechanism(s) by which inflammation contributes to the development of these diseases is essential for the development of therapeutic strategies against these diseases. The focus of my career research is to characterize these mechanisms and then to determine whether targeting of these mechanisms effectively prevents/treats these diseases. Specifically, I will focus on the molecular mechanism(s) underlying how exosome-like nanoparticles from healthy edible plants contribute to the inhibition of microphage-mediated inflammation. A positive outcome for this study would be significant for the development of future products that provide a basis for developing mechanism-driven novel strategies for the prevention of chronic inflammation via non-invasive oral administration of treatments, and thus improve the health status of members of the VA patient population.

PI_NAMEs: ZHANG, HUANG-GE  (contact)

PROJECT_TERMS: Acute;Address;Adipose tissue;Affect;aged;alcohol prevention;Alcohols;anergy;anti-cancer research;Antibodies;Antiinflammatory Effect;antimicrobial;Avena sativa;Award;Binding;Biology;Brain;Brain Diseases;Brain Neoplasms;Broccoli - dietary;c-myc Genes;cancer prevention;career;Cartilage;Cell Communication;Cell Differentiation process;cell type;Cells;chemokine;chemokine receptor;Chronic;Chronic Disease;Colitis;Colon Carcinoma;Colonic Neoplasms;Communication;Complex;Curcumin;cytokine;Data;dectin 1;Dendritic Cells;Development;dextran sulfate sodium induced colitis;Diabetes Mellitus;Diet;Disease;disease diagnosis;Disease Progression;DNA;Drug Targeting;Edible Plants;Encephalitis;Equilibrium;exosome;expression vector;Fibroblasts;Folic Acid;Food;Funding;Future;Garlic;Gene Expression;Genes;Ginger;Goals;Grapefruit;Grapes;Growth;gut bacteria;gut microbiome;gut microbiota;Health;Health Status;Healthcare;Hepatology;High Fat Diet;Homeostasis;Homing;Immune system;Immunity;Immunosuppression;Impaired cognition;improved;in vivo;Inflammation;Inflammatory;insight;Insulin Resistance;interleukin-22;interspecies communication;Intestines;joint inflammation;joint injury;Lactobacillaceae;Lactobacillus casei rhamnosus;lipid nanoparticle;Lipids;Liver;liver inflammation;Macrophage;Macrophage Activation;Malignant Neoplasms;Manuscripts;Mediating;Mediator;Medical;member;Memory;Metabolic;Methods;Microbe;Microglia;MicroRNAs;military veteran;Modeling;Molecular;mouse model;murine colitis;Mus;Myeloid-derived suppressor cells;nanoparticle;nanovector;Natural Killer Cell Immunotherapy;Nature;neoplastic cell;Nerve Degeneration;Neuroimmune;new therapeutic target;NK Cell Activation;non-alcoholic fatty liver disease;novel strategies;novel therapeutic intervention;Obese Mice;Obesity;Oncoproteins;Oral Administration;Outcome Study;Pathway interactions;patient population;Patients;Persian Gulf Syndrome;Pharmaceutical Preparations;Physiological;Plants;Post-Traumatic Stress Disorders;pressure;prevent;Prevention strategy;Probiotics;Promoter Regions;Publishing;recruit;Regulatory T-Lymphocyte;Research;Rheumatoid Arthritis;RNA;Role;S100A8 gene;Scientist;Shapes;side effect;Signal Pathway;Signal Transduction;Site;Small Interfering RNA;small molecule;Sodium Dextran Sulfate;Sorting;Specificity;stem cells;Surface;System;T-Cell Activation;T-Cell Development;targeted delivery;theranostics;Therapeutic;Therapeutic Agents;therapeutic development;therapeutic miRNA;tissue repair;Tissues;TP53 gene;translational study;treatment strategy;tumor;tumor progression;Tumor Suppressor Proteins;Vesicle;Veterans;Work

PROJECT_TITLE: BLRD Merit Review Research Career Scientist Award

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 RCSR-N (01)]


NIH_SPENDING_CATS: Aging;Cancer;Genetics

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

PHR: Project Narratives Dynamic biological acetylation regulates many facets of biological processes, including gene expression, genome stability, cellular metabolism, and chromatin organization. The conference brings together basic and translational scientists to discuss the fundamental mechanisms related to protein acetylation and its dysregulation in cancer and age-related diseases. The objectives of the conference are to 1) discuss new cutting-edge discoveries, 2) maximize new translational opportunities, 3) identify emerging new research directions and priorities, and 4) highlight the achievement of trainees and early career investigators via oral sessions, professional development forums, travel awards and other recognition.

PI_NAMEs: DOU, YALI  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: 3-Dimensional;Acetylation;Acetyltransferase;Achievement;age-related disease;Aging;American;Automobile Driving;Award;Awareness;Basic Science;Biochemistry;Biological;Biological Process;Biology;Bromodomain;cancer therapy;Carbon;career;career development;career networking;Cellular biology;Charge;Chemicals;Chromatin;Clinical;Clinical Research;Communities;Country;Crowns;Deacetylase;Dedications;design;Development;Developmental Biology;developmental disease;Disease;DNA biosynthesis;Docking;drug development;Drug Targeting;Educational workshop;Ensure;Equity;extend lifespan;Faculty;Fertilization;Fostering;Funding;Gene Expression;Generations;Genetic;Genome Stability;Germany;Goals;Growth;Growth and Development function;Health;Homeostasis;Immune response;Industry;inhibitor;innovation;insight;interdisciplinary collaboration;International;Investigation;Italy;Laboratories;Link;London;Lysine;Malignant - descriptor;Malignant Neoplasms;Medical;meetings;Mentorship;Metabolic;Metabolic Diseases;Metabolism;minority scientist;Modification;Molecular;Molecular Biology;Molecular Mechanisms of Action;Montana;novel;Oncogenic;Oral;overexpression;palmitoylation;Participant;Patients;Persons;Phosphorylation;Portugal;Postdoctoral Fellow;posters;pre-doctoral;Premature aging syndrome;Process;programs;Protein Acetylation;protein function;Proteins;Puerto Rico;Reader;Regulation;Research;Research Personnel;response;Role;Rome;Scientist;Side;Sirtuins;Site;small molecule inhibitor;Societies;stem cell function;Stress;structural biology;summer research;Sumoylation Pathway;Surveys;symposium;Talents;Technology;therapeutic development;therapeutic target;therapeutically effective;translational potential;Translational Research;translational scientist;Translations;Travel;treatment strategy;Underrepresented Minority;Underrepresented Populations;Woman;Work;Workplace

PROJECT_TITLE: Reversible Biological Acetylation in Health and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (J1)]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Nutrition;Obesity;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SALVADOR

ORG_COUNTRY: BRAZIL

ORG_FIPS: BR

ORG_NAME: FEDERAL UNIVERSITY OF BAHIA

PHR: Project narrative In the current proposal will investigate the influence of adipose tissue and obesity in the severity of cutaneous leishmaniasis. Our hypothesis is that adipokines, lipid profiles and leucocytes infiltrating adipose tissue are associated with inflammatory response-mediated tissue damage and severity of cutaneous leishmaniasis in obese patients. We will also study how lipids can reprogram macrophages towards a wound healing phenotype in cutaneous leishmaniasis.

PI_NAMEs: CARVALHO, LUCAS P (contact)

PROJECT_TERMS: Adipocytes;adipokines;adiponectin;Adipose tissue;Anti-Inflammatory Agents;Area;Asthma;Binding Proteins;Cardiovascular Diseases;CD8-Positive T-Lymphocytes;Cells;chemokine;cholesterol control;Cholesterol Homeostasis;Clinical;cohort;Cutaneous Leishmaniasis;CXCL10 gene;CXCL9 gene;cytokine;cytotoxicity;Data;Dermis;Desmosterol;Development;Disease;Elements;Failure;fatty acid metabolism;Gene Expression;Geographic Locations;healing;Hormones;Immune;immune function;Immune response;Individual;Infection;Inflammation;Inflammatory;Inflammatory Infiltrate;inflammatory modulation;Inflammatory Response;Interleukin-1 beta;Interleukin-6;Invaded;Leishmania braziliensis;Leptin;Lesion;Leucocytic infiltrate;Ligands;lipidomics;Lipids;Liver X Receptor;Lymphocyte;Macrophage;Mediating;Meglumine;Mononuclear;Morbidity - disease rate;mortality;Natural Killer Cells;obese patients;Obesity;Omega-3 Fatty Acids;Outcome;Parasites;Pathway interactions;Patients;peripheral blood;Phagocytes;Pharmaceutical Preparations;Phenotype;PPAR gamma;Process;Production;programs;Property;Psoriasis;Public Health;Reaction;receptor;Regional Disease;resistin;response;Role;Severities;Severity of illness;Signal Transduction;single-cell RNA sequencing;Site;Skin;skin lesion;skin organogenesis;skin ulcer;Sterols;Subcutaneous Tissue;Therapeutic;therapeutic target;therapy resistant;Thinness;Time;tissue repair;Tissues;TNF gene;transcription factor;transmission process;wound healing

PROJECT_TITLE: Adipocytes and inflammation in the cutaneous leishmaniasis outcome

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SAS-W (J1)]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_CITY: ELDORET

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: MOI UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: PUBLIC HEALTH RELEVANCE Next Generation Long lasting Insecticidal Treated Nets (LLINs) which combine a pyrethroid with a synergist that restores sensitivity in resistant mosquitoes are now recommended by the World Health Organization to mitigate insecticide resistance that has been documented in several areas and is threatening reversal of the gains made in controlling malaria. In Kenya, the distribution of PBO nets was done in mid-2021 in three high malaria burden counties (Bungoma, Kakamega and Busia), including among our cohort participants. Leveraging on our existing longitudinal cohort encompassing 500 people, the proposed work seeks to look at the impact of the PBO nets in real world implementation setting and explore human and entomological factors that may compromise effectiveness with the ultimate goal of informing co-interventions or other strategies that can maximize the impact of PBO and other next generation LLINs.

PI_NAMEs: MANGENI, JUDITH  (contact)

PROJECT_TERMS: Achievement;Adoption;Affect;Africa;Africa South of the Sahara;African;Age;Anopheles Genus;Archives;Area;Attention;Beds;Behavior;Behavioral;Biological Assay;Bite;burden of illness;Child;Clinical;cohort;Collection;Communities;community barrier;community engagement;Community Health Education;Complex;contextual factors;cost;County;Coupled;Culicidae;Data;Data Collection;Data Set;density;design;Dimensions;Disease;Drug resistance;Effectiveness;efficacy study;experience;Feedback;feeding;Female;Focus Groups;Future;Genetic Markers;Geographic Locations;Goals;Household;Human;Incidence;Individual;Infrastructure;Insecticide Resistance;Insecticides;Intervention;Interview;Kenya;Linear Models;Longitudinal cohort;Malaria;malaria infection;malaria transmission;Metabolic;Monitor;Morbidity - disease rate;mortality;next generation;Parasite resistance;Parasitology;Participant;Persons;Phase;Phenotype;Population;Prevention;programs;Public Health;public health relevance;pyrethroid;Recommendation;Resistance;Resources;Rest;Rural;Sampling;Specimen;stakeholder perspectives;Standardization;Statistical Models;Structure;success;Surveys;Techniques;Time;tool;transmission process;uptake;vector;Vulnerable Populations;Work;World Health Organization

PROJECT_TITLE: Real-World Impact of Next Generation Insecticidal Nets for Malaria Control in Rural Western Kenya


NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD)

PHR: PROJECT NARRATIVE  Aneuploidy, an abnormal number of chromosomes, is associated with many human conditions and diseases, including miscarriages, birth defects, and cancer. In this proposal, we are requesting grant support to bring together the world’s experts in the field of aneuploidy to share their latest findings during the Federation of American Societies for Experimental Biology sponsored conference “The Consequences of Aneuploidy.” The goal of the meeting is to advance our understanding of how aneuploidy impacts human health and disease which will lead to new therapeutic strategies that prevent aneuploidy, eliminate aneuploid cells, and treat the symptoms of aneuploidy associated conditions.

PI_NAMEs: GODEK, KRISTINA M (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Advocate;Aging;American;Aneuploid Cells;Aneuploidy;Automobile Driving;Biological Models;Biology;blastocyst;career;career development;Cells;Chromosome 21;chromosome number abnormality;Chromosomes;Collaborations;Communities;Congenital Abnormality;cost;Dedications;Development;Disabled Persons;Disease;Down's Syndrome;Ensure;Environment;Ethnic Origin;Experimental Models;Female;Florida;Fostering;Gender;Goals;Grant;hallmarks of aging;Health;Human;Human Development;International;Intervention;male;Malignant Neoplasms;Massachusetts;meetings;Memory;novel therapeutic intervention;outreach;Pathology;posters;prevent;programs;Race;Recurrence;Rehabilitation therapy;Research;Research Personnel;Science;Scientist;Series;Societies;Spontaneous abortion;success;symposium;symptom treatment;Techniques;therapeutic target;Tissues;Trisomy;tumorigenesis;Underrepresented Minority;Underrepresented Populations;United States

PROJECT_TITLE: The Consequences of Aneuploidy

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Microbiome

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE: Symbiotic relationships formed early in life with skin commensal microorganisms can promote health and restrict damaging inflammation. Understanding the cellular and molecular determinants of these interactions has the potential to inform novel therapeutic strategies for chronic inflammatory disease. Studies in this proposal aim to understand the mechanisms by which commensal bacteria influence the functional dynamics of the developing myeloid compartment in neonatal skin and the consequences of these interactions for cutaneous health and disease.

PI_NAMEs: DHARIWALA, MIQDAD ONALI (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Adult;Atopic Dermatitis;Automobile Driving;Biological Assay;Bone Marrow;career;CD4 Positive T Lymphocytes;Cell Physiology;Cells;chemokine;Chemotaxis;Chronic;chronic inflammatory disease;chronic inflammatory skin;commensal bacteria;commensal microbes;comparative;Cues;Cutaneous;Cytometry;Data;Development;Disease;early life exposure;Environment;Genetic;Gnotobiotic;Goals;Health;Health Promotion;Hidradenitis Suppurativa;high throughput screening;Homeostasis;Human;human tissue;humanized mouse;IL17 gene;Immune;Immune system;Immune Tolerance;Immunity;Immunology;imprint;improved;In Vitro;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammatory;innovation;International;keratinocyte;Life;Link;Lymphocyte;Measures;Mentorship;metabolomics;Microbe;microbial;Microbiology;microorganism;Molecular;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;Natural Immunity;Neonatal;neonatal human;neonate;next generation;novel;novel therapeutic intervention;Pathology;Pathway interactions;Phenotype;Play;Population;Positioning Attribute;Postdoctoral Fellow;Predisposition;Production;programs;Psoriasis;Receptor Signaling;Recovery;recruit;Regulatory T-Lymphocyte;Research;response;Role;Sentinel;Shapes;Signal Transduction;single-cell RNA sequencing;Skin;skin disorder;symbiont;symposium;Systems Development;T-Lymphocyte;Techniques;Testing;Therapeutic;Tissues;Toll-like receptors;tool;trafficking;Training;Transgenic Mice;Translational Research;translational study;Work

PROJECT_TITLE: Elucidating microbial and host mechanisms supporting early life immune imprinting by skin monocytes

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Decision making is an important cognitive function that is impaired in psychiatric diseases like substance use disorder (SUD). This proposal aims to investigate the role that dopamine plays in the neuronal circuit that underlies decision making. A better understanding of the circuitry underlying decision-making will help us understand why maladaptive behavior arises in disorders like SUD and may lead to advancements in therapeutics for SUD which affect about 37 million Americans.

PI_NAMEs: MWENDA, NKATHA KARIMI (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Acceleration;Affect;American;Animals;Behavior;Binding;Brain region;career;Cells;Chemosensitization;Cocaine;cocaine seeking;cocaine self-administration;cocaine use;cognitive function;Communication;comparison control;Corpus striatum structure;Data Analyses;Decision Making;Development;Disease;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;Dopamine Receptor;dopaminergic neuron;Dorsal;Drug Addiction;drug of abuse;drug reward;Drug usage;Electrophysiology (science);Equilibrium;Event;Food;Grant;high risk;Impairment;Injury;Laboratory Finding;Lead;Learning;Life;maladaptive behavior;Manuscripts;Medial;Mental disorders;Mentors;Mission;Mus;National Institute of Drug Abuse;neuronal circuitry;Neurons;Nose;optogenetics;Oral;Pathway interactions;Phase;Play;Postdoctoral Fellow;postsynaptic;Predatory Behavior;preservation;Principal Investigator;Punishment;receptor binding;Research;Resistance;Rewards;Risk;Role;Science;Signal Transduction;skills;Slice;Substance Use Disorder;Sucrose;symposium;Synapses;System;Testing;Therapeutic;tool;Training;Writing

PROJECT_TITLE: The role of dopamine in OFC-DMS plasticity in punishment-resistant reward-seeking behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: PROJECT NARRATIVE GlycoRNAs are a newly discovered biopolymer that intersect RNA biology and glycobiology. Currently, glycoRNAs have no identified function and whether they are involved in health or disease is unknown. The work in this proposal will reveal how glycoRNAs function in innate immunity and host-pathogen interactions.

PI_NAMEs: GRAZIANO, VINCENT ROBERT (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Alkynes;Antibodies;Azides;Base Sequence;Binding;Binding Proteins;Biology;Biopolymers;career;Cell surface;Cells;Chemistry;cytokine;Data;Detection;Disease;Double-Stranded RNA;Endosomes;Enzyme-Linked Immunosorbent Assay;Exhibits;experimental study;Family;Fellowship;Flow Cytometry;Funding;Genetic Transcription;Glycobiology;Glycoside Hydrolases;glycosylation;Goals;Health;Hela Cells;Herpesvirus 1;Host Defense;Immune;immune activation;Immune response;Immune system;Immunologic Receptors;Immunologic Stimulation;Immunology;In Vitro;in vivo;Individual;Infection;Inflammatory;Influenza;Innate Immune Response;innate immune sensing;Innate Immune System;Interferon Type I;Interferons;Invaded;Knockout Mice;Knowledge;Length;Link;Lipopolysaccharides;Macrophage;Mammalian Cell;Maps;Measures;Mediating;Mentorship;Modeling;Molecular;Monitor;Mus;Natural Immunity;Neuraminidase;Northern Blotting;novel;Nucleic Acids;pathogen;pathogen genome;Pathway interactions;Pattern;Peptide N-glycohydrolase F;Physiological;Polysaccharides;posttranscriptional;prevent;Production;protein complex;Proteins;receptor;Research Personnel;response;Rest;Ribonucleases;RNA;RNA Binding;Role;Salmonella typhimurium;sensor;Sentinel;Sepsis;Sialic Acids;Signal Pathway;Small RNA;Splenocyte;Structure;Surface;The Jackson Laboratory;TLR3 gene;TLR4 gene;training opportunity;transcriptome;transcriptome sequencing;Transfection;Untranslated RNA;viral RNA;Virulence Factors;Virus Diseases;Western Blotting;Work

PROJECT_TITLE: Innate immune roles of glycoRNA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]