ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Health Services;Networking and Information Technology R&D (NITRD);Palliative Care;Patient Safety;Social Determinants of Health

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Oral anticancer agents (OAAs) account for over half of the new cancer treatments approved by the Food and Drug Administration. For older adults who are taking OAAs and self-managing care in the home environment, research is crucial for the development of supportive interventions to improve communication, information exchange, and self-efficacy in the management complex OAA and related symptoms/side effects. This study will explore concordance of the timing, frequency, and continuity of information sharing, communication, and knowledge gaps between patients, caregivers, and oncology health care providers specific to OAA treatment; examine patient-reported outcomes associated with OAA self-management; and to explore perceptions of supportive web-based program design features that may assist with the development of future intervention tool.

PI_NAMEs: MARSHALL, VICTORIA KATE (contact)

PROGRAM_OFFICER_NAME: D'ANGELO, HEATHER

PROJECT_TERMS: Address;Adherence;Adult;Affect;Android;Antineoplastic Agents;behavior change;Behavioral;cancer care;cancer therapy;care providers;Caregivers;Caring;Cellular Phone;chemotherapy;Clinic;Communication;comorbidity;Complex;Computers;Continuity of Patient Care;coping;Data;design;Development;Dose;Drug toxicity;efficacy testing;financial toxicity;flexibility;Food-Drug Interactions;Frequencies;Funding;Future;Glean;Goals;Grant;Health Insurance;health literacy;Health Personnel;Health Technology;Home;Home environment;human old age (65+);improved;Incidence;Income;insight;Instruction;Internet;Intervention;Intervention Studies;Interview;Knowledge;literacy;Malignant Neoplasms;Managed Care;medication administration;Medication Management;Methods;mHealth;Mobile Health Application;Modeling;Monitor;Motivation;older adult;Oncology;Online Systems;Oral;Outcome;Ownership;Palliative Care;Patient Outcomes Assessments;Patients;Perception;Personal Computers;Pharmaceutical Preparations;Pharmacologic Substance;Polypharmacy;Problem Solving;Program Acceptability;programs;Provider;Questionnaires;Randomized, Controlled Trials;Regimen;Reporting;Research;response;satisfaction;Self Efficacy;Self Management;side effect;Social support;Solid Neoplasm;symptom management;Symptoms;Tablets;Technology;technology platform;Theory of Change;Time;tool;treatment comparison;United States Food and Drug Administration;usability;web-based assessment

PROJECT_TITLE: Exploring the Use of a Web-Based Program for Older Adults Receiving Oral Anticancer Agents to Improve Communication and Self-Management


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences;Social Determinants of Health

ORG_CITY: NEW ORLEANS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: This program leverages multi-university partnerships to provide structured mentored research experiences in neuroscience to undergraduate students from underrepresented / underserved populations in Louisiana. This is accomplished through summer and year-round mentor and mentee training in science, critical thinking, professional, and career skills. The program will increase the number of diverse applicants prepared for independent research, graduate school, and, ultimately, careers in neuroscience, helping to address population disparities in neurological diseases.

PI_NAMEs: AUGUSTUS-WALLACE, ALLISON CHARLEMAGNE (contact);EDWARDS, SCOTT ;FARRIS, HAMILTON E;MOLINA, PATRICIA E.;TSIEN, FERN F

PROGRAM_OFFICER_NAME: JONES, MICHELLE

PROJECT_TERMS: Academic advising;Address;Admission activity;African American;Area;biomedical profession;Brain;career;career awareness;Career Choice;career development;career networking;Clinical;Communication;Communities;community engagement;community research;Competence;Critical Thinking;cultural competence;Data Analyses;design;Development;Disabled Persons;disadvantaged background;Disparity;Disparity population;Doctor of Philosophy;Education;educational atmosphere;Educational Curriculum;Educational workshop;electronic data;empowerment;Equity;equity, diversity, and inclusion;Evaluation;evidence base;expectation;experience;Faculty;faculty mentor;Future;Goals;Graduate Education;graduate school;graduate student;Health;health disparity;Health Occupations;High Prevalence;Hispanic Populations;Historically Black Colleges and Universities;improved;in vitro Model;in vivo;Institution;interest;Internships;Interview;laboratory experience;Leadership;Louisiana;Medical Ethics;Mentors;Mentorship;Methodology;Mind;Minority-Serving Institution;Motivation;Multimedia;Nervous System Disorder;Neurosciences;Neurosciences Research;next generation;Participant;Pathway interactions;Performance;Population;Preparation;Probability;Problem Solving;Professional Competence;programs;Publications;Reading;recruit;Research;research and development;Research Personnel;Resources;satisfaction;Schools;Science;Science Enrichment;Self Efficacy;skill acquisition;skills;social;Structure;Students;success;Surveys;Time;Time Management;tool;Training;undergraduate student;Underrepresented Students;Underserved Population;Universities;Work

PROJECT_TITLE: Inspiring Diversity to Explore the Brain in the 21st Century: The NIHNDS/LSUHSC-NO, Undergraduate Diversity in Neuroscience Research Experiences


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Neuroblastoma is the most common extracranial solid tumor of childhood, and despite significant advances in the diagnosis and treatment of this disease, the prognosis for many patients remains poor. Overexpression of multidrug resistance protein 1 (MRP1) is strongly associated with neuroblastoma drug resistance and reduced patient survival. This proposal seeks to identify the structural basis by which MRP1 promotes neuroblastoma drug resistance, and completion of the proposed work will lay a foundation for future therapeutic development.

PI_NAMEs: PIETZ, HARLAN LINVER (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: ABCB1 gene;Address;American;Amino Acids;Anti-tumor Natural Products;Antineoplastic Agents;Antioxidants;ATP-Binding Cassette Transporters;Binding;Binding Sites;Biochemical;Biological Assay;Biophysics;career;Cattle;Cell membrane;Cells;Cellular Assay;Cephalic;Characteristics;Charge;chemotherapeutic agent;Child;Childhood Extracranial Solid Tumor;Clinical;Collaborations;Communication;Complement component C4a;Complex;Coupled;Cryoelectron Microscopy;Cyclic Peptides;Cytoplasm;design;Development;Diagnosis;Disease;disorder risk;Disseminated Malignant Neoplasm;Doctor of Philosophy;Doxorubicin;Drug resistance;Educational Curriculum;Environment;Equipment;Etoposide;Event;Fellowship;Foundations;Future;Glutathione;Glutathione Disulfide;Health Promotion;high risk;Homeostasis;Homologous Gene;Human;Hydrophobicity;improved;insight;Institution;Laboratories;Leukotriene C4;Libraries;Ligand Binding;Ligands;Literature;Measures;Mediating;Medical;Medicine;Membrane;Membrane Biology;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;Methotrexate;Molecular;Molecular Conformation;Molecular Structure;Multi-Drug Resistance;multidrug transport;Mutagenesis;Mutation Analysis;Nature;Neuroblastoma;New York City;novel;overexpression;particle;Pathologic;Patients;Peptides;Pharmaceutical Preparations;Phase;Physicians;Physiological;preservation;Productivity;Prognosis;programs;Regulation;Research;Resources;Scientist;Site;skills;Solid Neoplasm;structural biology;Structure;Testing;therapeutic development;Therapeutic Intervention;Training;Treatment Failure;tumor;Universities;Verapamil;Vincristine;Work;Xenobiotics

PROJECT_TITLE: Studies of the structural and functional basis of neuroblastoma drug resistance


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Many animals perform complex behaviors that are the result of varying arousal/motivational states, though identifying these states by behavior alone is challenging. In turn, how these states influence specific neuronal circuits to alter behavior is diffifcult in complex brains, but tractable in smaller invertebrate brains. We propose to use orb-weaving spiders to investigate how neuromodulation organizes behavioral states, and nematodes to understand how these states alter neuronal architecture.

PI_NAMEs: GORDUS, ANDREW GEORGE (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TITLE: The influence of neuronal states on perception and behavior

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease

PHR: PROJECT NARRATIVE Inflammatory bowel diseases affect 1 in 200 Americans. Human studies have elucidated that signaling between key immune cells and stromal cells drive disease pathogenesis and determine response to therapy. This project will utilize an important pre-clinical genetic mouse model with direct relevance to at least 10% of patients with IBD to study these signaling pathways and interactions with micronutrient (zinc and manganese) availability.

PI_NAMEs: MELIA, JOANNA MILLER PELOQUIN (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Affect;American;Anti-Tumor Necrosis Factor Therapy;Biological Assay;Bone Marrow;Cells;chemokine;Clinical;clinical practice;Colitis;Collagen;Colon;CRISPR/Cas technology;Crohn's disease;cytokine;Data;dextran sulfate sodium induced colitis;differential expression;Disease;disease-causing mutation;Exhibits;experience;Family;Fibroblasts;Fibrosis;Future;Genetic;Genotype;Goals;Homeostasis;Human;human data;human disease;Human Genome;Hydroxyproline;Immune;Impairment;Inflammatory;Inflammatory Bowel Diseases;Innate Immune Response;insight;Interleukin-11;Interleukin-6;Intestinal Fibrosis;Knock-in;Knock-in Mouse;Link;Macrophage;Macrophage Activation;Manganese;Measures;Mediating;member;Metals;Methods;Micronutrients;Modeling;mouse model;Mucous Membrane;Mus;novel;Operative Surgical Procedures;Orthologous Gene;overexpression;Pathogenesis;Pathology;Patients;Penetration;Phenotype;Population;Positioning Attribute;pre-clinical;Predisposing Factor;Predisposition;Prevention;Process;Production;profibrotic cytokine;programs;PTPRC gene;Recovery;Refractory;Refractory Disease;Regulation;Reporting;response;Risk;risk variant;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sodium Dextran Sulfate;STAT3 gene;Stimulator of Interferon Genes;Stromal Cells;therapeutic target;Tissues;TNF gene;transcriptome sequencing;translational model;treatment response;Ulcerative Colitis;Variant;Western Blotting;Work;Zinc

PROJECT_TITLE: Elucidating mechanisms of fibrosis associated with the Crohns disease-associated pathogenic variant in the metal transporter ZIP8

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Diagnosing TDP-43 proteinopathy in living patients with frontotemporal lobar degeneration or Alzheimer’s disease is difficult due to the heterogeneity of clinicopathologic relationship, and molecular composition of TDP- 43 pathology. The purpose of this study is to elucidate a novel toxic TDP-43 species and its association with pathology and neurodegeneration. The long-term goal is to develop a biomarker that can predict the presence of TDP-43 in living frontotemporal lobar degeneration and Alzheimer’s disease patients, which will have a significant impact on future therapies for both diseases.

PI_NAMEs: MAO, QINWEN  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease patient;Amino Acid Sequence;Amyloid beta-Protein;Antibodies;Area;behavioral variant frontotemporal dementia;Binding;Biological Markers;Blood;Brain;Brain region;C-terminal;C9ORF72;Cerebrospinal Fluid;Classification;Clinical;clinical phenotype;Complex;Cytoplasm;Dementia;density;Deposition;Diagnosis;Disease;DNA Sequence Alteration;drug discovery;effective therapy;Exclusion;Foundations;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Funding;Future;Goals;Heterogeneity;hippocampal sclerosis;Human;Immunohistochemistry;improved;Knowledge;Length;Link;meetings;Molecular;Molecular Conformation;Monoclonal Antibodies;Motor Neuron Disease;Nerve Degeneration;neuron loss;neuropathology;novel;Pathologic;Pathology;Patients;Phenotype;Phosphorylation;Pilot Projects;Primary Progressive Aphasia;protein TDP-43;Proteomics;Public Health;Reporting;Role;screening;Symptoms;Syndrome;tandem mass spectrometry;tau Proteins;Testing;therapeutic target;Uncertainty

PROJECT_TITLE: A new biomarker for frontotemporal lobar degeneration with TDP-43 proteinopathy and Alzheimer's disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE Humans differ in their susceptibilities to disease, and individual cells within a population of infectious microbes or a tumor differ in their susceptibilities to drugs. Understanding the causes of differences within populations is therefore of great importance in human health. By developing and applying methods for simultaneous measurement of many individual cells, this research program aims to advance understanding of the complex ways genetic and nongenetic factors combine to make individuals more or less similar to one another.

PI_NAMEs: SIEGAL, MARK L (contact)

PROGRAM_OFFICER_NAME: KRASNEWICH, DONNA M

PROJECT_TERMS: acute stress;Biological Models;Biomedical Research;Cell Shape;Cell Size;Cells;chemical genetics;Clinical;Complex;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Disease;disorder risk;experimental study;Genes;Genetic;Genetic Epistasis;genetic manipulation;Genotype;Goals;Growth;Health;Heterogeneity;Human;Individual;Infection;Knowledge;Malignant Neoplasms;Measurement;Mediating;Methods;Microbe;microbial;Microscopy;Molecular;Mutation;neoplastic cell;non-genetic;pathogen;pathogenic microbe;Pathway interactions;personalized medicine;Pharmaceutical Preparations;Phosphotransferases;Population;Predisposition;pressure;Process;programs;Research;response;Role;Saccharomyces cerevisiae;Saccharomycetales;single cell analysis;Source;stress tolerance;trait;tumor;Uncertainty;Variant;Virus;Work

PROJECT_TITLE: Genetic and Nongenetic Variation in Complex Traits

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: HOWARD UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative We propose a full-time eight-week summer research experience program at Howard University, aiming at engaging, recruiting and training undergraduate students from underrepresented minority and other disparity populations into minority health care and oral health disparity research. The program is designed to be a specialized didactic and mentored academic program with tailed research and education activities. We will also develop a highly networked team of motivated and skilled mentors from various disciplines by establishing a strong partnership between Howard and Johns Hopkins Universities. By participating in multi-disciplinary research projects and education events, the students will gain valuable research experience and knowledge, and promote them into advanced education in oral health disparity.

PI_NAMEs: GU, XINBIN  (contact);WU, TZYY-CHOOU

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: academic program;Address;Advisory Committees;African American population;Area;Biomedical Research;career;career development;Caring;Clinic;Clinical;college;Communities;community based research;craniofacial;cultural competence;Dental;Dental Schools;Dentistry;design;Diagnosis;Discipline;Disparity;Disparity population;disparity reduction;Doctor of Philosophy;Education;education research;Educational Activities;Environment;Ethnic Population;Evaluation;Event;experience;Financial Support;Foundations;Funding;Goals;health care delivery;health care service;Health Disparities Research;health disparity;Health Occupations;Health Professional;Healthcare;Historically Black Colleges and Universities;Improve Access;improved;Infrastructure;Interdisciplinary Study;Knowledge;Laboratories;lectures;Low Income Population;Medicine;member;Mentors;Minority;Minority Groups;minority healthcare;minority investigator;Mouth Diseases;National Institute of Dental and Craniofacial Research;Oral;Oral health;Postdoctoral Fellow;pre-doctoral;Privatization;programs;public health research;Qualifying;racial disparity;recruit;Research;Research Activity;research and development;Research Personnel;Research Project Grants;Research Training;Resources;role model;Science Enrichment;Scientist;Secure;Series;skills;student mentoring;student participation;Students;summer research;System;Tail;Time;Training;Training and Education;Training and Infrastructure;Training Programs;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;underserved minority;Underserved Population;United States;Universities;Vulnerable Populations;Washington;Writing

PROJECT_TITLE: Howard University Summer Research Education Experience Program in Oral Health


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Most deaths related to hematologic malignancies such as multiple myeloma (MM) or myeloid leukemias are caused by the inability of applied systemic treatments to eradicate all tumor cells and prevent formation of treatment-persistent residual tumor cell populations that will become the “seed” for eventual relapses and inability to achieve curative outcome. A better understanding of how this “minimal" residual disease (MRD) in MM or leukemia persists through pharmacological therapies is essential to develop new treatments that can decrease the burden of cancer-related deaths. This project seeks to study MM or leukemia cells which have developed persistence to chemotherapy or other drugs with cytotoxic activity against tumor cells and we will specifically characterize the mechanisms which regulate whether these MRD tumor cells will respond or not to natural killer (NK) cells, in order to better inform the development of future immunotherapies that can eradicate the residual malignant cells of MM or leukemias and bridge the gap towards curative outcomes for these diseases.

PI_NAMEs: MITSIADES, CONSTANTINE S. (contact);MUSTJOKI, SATU

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Acute Myelocytic Leukemia;Apoptotic;Biochemical;Biology;Cancer Burden;cancer cell;cancer therapy;Cell Communication;Cell Compartmentation;Cell Line;Cell Therapy;Cells;Cessation of life;Characteristics;chemotherapy;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;cytotoxic;Cytotoxic agent;Cytotoxic Chemotherapy;Cytotoxic T-Lymphocytes;Data;Defect;Development;Diapause;Disease Outcome;Disease remission;drug withdrawal;Early identification;Embryo;Exhibits;experience;Experimental Models;Future;Genes;Genetic Transcription;Genomics;Hematologic Neoplasms;Hematopoietic Neoplasms;Immune;Immune checkpoint inhibitor;Immunotherapy;In Vitro;in vivo;Individual;insight;Investigation;Knowledge;leukemia;Leukemic Cell;Molecular;Molecular Profiling;Multiple Myeloma;Myeloid Leukemia;myeloid leukemia cell;Natural Killer Cells;neoplastic cell;non-genetic;non-genomic;Outcome;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Population;Pre-Clinical Model;prevent;Relapse;relapse patients;Research;Residual Neoplasm;Residual state;Resistance;response;Role;Sampling;Solid Neoplasm;Stress;Testing;Therapeutic;therapy resistant;Transcript;tumor;Writing

PROJECT_TITLE: Mechanisms of natural killer cell resistance of treatment-persistent residual tumor cells in hematologic malignancies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-S(09)F]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative The goal of this application is to extend and enhance our current highly successful R38 program allowing for continued identification and engagement of those pediatric and medicine residents with the aptitude and passion to become clinician-scientists through our mentored training program. We will focus on research themes where Vanderbilt has internationally recognized programs of discovery combined with a record of sustained excellence in research mentorship. Each R38 Resident Investigator will have an individualized training program developed by the Preceptors and Training Directors in collaboration with a multidisciplinary scientific oversight team, and will be supported by a broad array of institutional and departmental resources with the expectation that graduates will transition to well-established long-term clinician-scientist career development programs at Vanderbilt or other research intensive institutions.

PI_NAMEs: DEBAUN, MICHAEL R.;WILLIAMS, CHRISTOPHER S. (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Academic Medical Centers;Appointment;Aptitude;Area;Award;career;career development;Childhood;Clinical;Collaborations;Community Developments;Competence;Development Plans;diversity and inclusion;Doctor of Philosophy;Educational workshop;Environment;Evaluation;expectation;experience;Faculty;Feedback;Fellowship;Funding;Generations;Goals;Grant;Human Resources;improved;Infrastructure;Institution;interest;International;Investigation;Location;Longterm Follow-up;Medical center;Medical Education;medical schools;Medicine;Mentors;Mentorship;Minor;Mission;multidisciplinary;National Heart, Lung, and Blood Institute;Outcome;Pathway interactions;Pediatrics;Peer Review;Performance;Phase;population health;Positioning Attribute;Process;Productivity;Program Development;programs;Publications;Qualifying;Records;recruit;Research;Research Personnel;Research Project Grants;Research Training;Residencies;Resources;response;Scientist;Strategic vision;Structure;success;tenure track;Time;Training;Training Programs;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Vanderbilt Stimulating Access to Research in Residency (V-StARR)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Suicide;Suicide Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: BUTLER HOSPITAL (PROVIDENCE, RI)

ORG_STATE: RI

PHR: Project Narrative Suicidal ideation and behavior are increasingly serious public health concerns, particularly for individuals recently discharged from psychiatric hospitalization for suicidal ideation or behavior. We propose the development of an integrated, multimethod model of acute suicide risk emphasizing proximal (i.e., momentary affective, cognitive, and contextual) risk factors and the moderating effect of more distal risk factors, based on data collected from a combination of intensive ecological momentary assessment, digital phenotyping, laboratory-based behavioral assessments, and traditional cross-sectional measures (i.e., clinical interviews and self-report questionnaires). We believe that this integrated multimodal approach will yield improved prediction of suicidal ideation and behavior as they occur in individuals' daily lives.

PI_NAMEs: ARMEY, MICHAEL F (contact);HUGHES, CHRISTOPHER DAVID;SCHATTEN, HEATHER

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: Acute;Affect;Affective;American;Back;Behavior;Behavior assessment;Behavioral;Caring;Cellular Phone;Clinical;Cognition;Cognitive;Communities;Conflict (Psychology);contextual factors;Data;Data Collection;Development;Diagnostic;digital phenotyping;Distal;Ecological momentary assessment;Emotions;Enhancement Technology;Environment;experience;Face;Feeling suicidal;follow up assessment;follow-up;Future;high risk;hospital readmission;Hospitalization;Hour;improved;in vivo;indexing;Individual;Infrastructure;inpatient psychiatric treatment;insight;Interruption;Intervention;Interview;Laboratories;Life;Link;Location;Measurement;Measures;Methods;Modeling;Monitor;Movement;multimodality;negative affect;Network-based;Outcome;Outcome Study;Participant;participant observation;Patient Self-Report;Patients;Pattern;pediatric trauma;Persons;phenomenological models;phenotypic data;Play;prevent;Prevention;primary outcome;Process;psychiatric inpatient;Public Health;Questionnaires;recruit;Research;response;Risk;Risk Assessment;Risk Behaviors;Risk Factors;Sampling;secondary outcome;sensor;Sleep;Sleep disturbances;social;Social Interaction;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;suicide rate;Thinking;Time;Typology;United States;wearable device

PROJECT_TITLE: Ecological Assessment of Proximal Risk Factors for Suicide During Care Transitions

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Activation of the immune system by immunotherapy can be used for the treatment of cancer but major gaps in our knowledge compromise optimal outcomes. This project will study how immunotherapy affects the properties of CD8+ T effector and T regulatory cells and their crosstalk with other immune components of the tumor microenvironment. This work may significantly improve the outcome of immunotherapy and provide a major benefit to cancer patients.

PI_NAMEs: BOUSSIOTIS, VASSILIKI A (contact);VLACHOS, IOANNIS

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Ablation;Affect;anti-cancer therapeutic;Antibodies;Antigen-Presenting Cells;Antitumor Response;B-Lymphocytes;Binding;Biochemical;Biopsy;cancer cell;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;CD80 gene;CD8B1 gene;cell type;Cells;checkpoint therapy;Clinical Trials;Cytoplasmic Tail;Detection;Development;exhaustion;fatty acid oxidation;Genes;Human;Immune;immune activation;Immune system;Immunologics;Immunosuppression;Immunotherapy;improved outcome;Individual;Infiltration;inhibitor;Knowledge;Ligands;lipid metabolism;Macrophage;Malignant Neoplasms;Mediating;Memory;Modeling;Molecular;Molecular Profiling;monocyte;Mus;Neurotransmitters;novel;Outcome;outcome prediction;Pathway interactions;Patients;Pattern;PD-1 blockade;peripheral blood;Phosphotyrosine;Physiological;Production;prognostic significance;programmed cell death ligand 1;programmed cell death protein 1;Property;Proteins;receptor;Regulatory T-Lymphocyte;response;Shapes;Signal Induction;Signal Transduction;success;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;transcriptomics;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Tyrosine;Work

PROJECT_TITLE: Detection of PD-1 inhibitory signaling and its molecular relays in T cells: Implications for cancer immunotherapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_DEPT: DENTISTRY

PHR: NARRATIVE: This study investigates how major Lactobacillus sp. establish and persist in a mixed-species consortium and interacts with Streptococcus mutans, and how S. mutans-Lactobacillus interactions influence Lactobacillus’ establishment and the dynamics of a mixed-species community under conditions typical of the oral cavity. The results derived from this study should provide us new insights on plaque biofilm ecology and caries etiology and could facilitate the development of novel strategies against dental caries.

PI_NAMEs: WEN, ZEZHANG TOM (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acids;Adopted;Amino Acids;Anabolism;antagonist;Bacteria;Bacterial Adhesins;bacterial metabolism;bacteriocin;biofilm species;Biological Assay;Caring;Clinical;Code;Collection;Communicable Diseases;Communities;Complex;Consumption;cost;Cues;dental biofilm;Dental caries;Dental Plaque;Development;Disease;dysbiosis;Ecology;Emergency Situation;Etiology;Foundations;Functional disorder;Genes;genetic regulatory protein;Glucans;Glucosyltransferase;Goals;Health;Hour;Hydrogen Peroxide;In Vitro;in vitro Model;Indigenous;insight;Inverse Polymerase Chain Reaction;Investigation;Knowledge;Lactobacillus;Lactobacillus casei;Lead;Lesion;Libraries;Link;Mechanics;Mediating;member;Metabolic;metabolomics;Microbial Biofilms;microbiota;Modeling;Mutagenesis;mutant;novel;novel strategies;Oral;Oral cavity;Outcome;pathogen;Pathogenicity;Peptides;Polysaccharides;Production;productivity loss;Proteins;response;Role;Saliva;Site;Source;Streptococcus mutans;stressor;Sucrose;sugar;Surface;Testing;tooth surface

PROJECT_TITLE: More Than Mechanical Retention: Characterization of Lactobacillus Clinical Strains Using In Vitro Models

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: NARRATIVE: SOD-OHSU R25 Summer Research Education Experience Application (PAR-21-168) To open Dentistry and Oral Research Summers (DORS) in Oregon The overall goal of the SOD R25 Summer Research Experience is to open doors for undergraduate scholars in pursuing a career in dental, oral, and craniofacial research and to increase representation within our research community from rural Oregon and from under-represented communities within Oregon. By presenting the opportunities and rewards that lie in being a research scientist and addressing barriers, we will transform learners who are interested in summer research to oral health researchers at all levels.

PI_NAMEs: LAMPI, KIRSTEN JEANNE (contact);WU, HUI

PROJECT_TERMS: Address;Advisory Committees;Biomedical Research;career;cohort;Communities;community based research;Community Dentistry;community partners;comparison group;craniofacial;Dental;Dental Materials;Dental Schools;Dentistry;Dentists;design;diversity and inclusion;early experience;education planning;education research;Environment;Equity;Evaluation;experience;experimental study;Funding;Goals;graduate school;Grant;Health Professional;Human Resources;Infrastructure;innovation;interest;Internships;Investments;Laboratories;Leadership;Mentors;National Institute of Dental and Craniofacial Research;Native Americans;nutrition;operation;Oral;Oral health;Oral Microbiology;Oregon;Outcome;Pathway interactions;peer coaching;programs;recruit;Research;Research Personnel;Rewards;Rural;rural area;Rural Community;Rural Health;rural underrepresented;School Dentistry;Scientist;Site;Students;success;summer internship;summer program;summer research;Surveys;synergism;tissue regeneration;Training;training opportunity;Training Programs;undergraduate research;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;urban area;Work

PROJECT_TITLE: Opening Dental and Oral Research Summers (DORS) to Scientific Careers throughout Oregon


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Rare Diseases

PHR: Project Narrative Lung cancer is the leading cause of cancer death worldwide, and lung adenocarcinoma is the most frequently diagnosed subtype of this disease. The proposed research will investigate molecular regulators of identity in lung adenocarcinoma and provide fundamental knowledge required for the design of integrative therapeutic strategies that target this disease on the basis of differentiation state-specific vulnerabilities as well as actionable mutations.

PI_NAMEs: SNYDER, ERIC LEE (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: acquired drug resistance;actionable mutation;Adenocarcinoma Cell;Adopted;Automobile Driving;Biological;cancer cell;Cancer Etiology;Cell Line;Cell Lineage;cell type;Cells;Cessation of life;Chief Cell;ChIP-seq;Chromatin;Clinical;clinically relevant;Complex;Data;Dependence;design;Diagnosis;Disease;disorder subtype;Drug resistance;Drug Tolerance;Epigenetic Process;epigenomic profiling;Equilibrium;Exhibits;Gastric Chief Cells;gastrointestinal;Genetic Transcription;Genetically Engineered Mouse;Goals;Growth;Heterogeneity;Histologic;Human;human model;Impairment;inhibitor;Knowledge;LGR5 gene;Lung;Lung Adenocarcinoma;Malignant neoplasm of lung;Modeling;Molecular;Morphology;mouse model;Mucous Membrane;neoplastic cell;novel;Oncogenic;Organoids;Pathway interactions;patient derived xenograft model;patient prognosis;pharmacologic;Phosphorylation;Predisposition;Primary Neoplasm;programs;Proliferating;Publishing;Regulation;Research;Residual Neoplasm;Residual state;Resistance;Role;Signal Pathway;Signal Transduction;Specific qualifier value;Stomach;Surface;targeted treatment;Testing;Therapeutic;Time;Transcriptional Regulation;transcriptome sequencing;tumor heterogeneity;tumor progression;tumorigenesis;tumorigenic;WNT Signaling Pathway;Work

PROJECT_TITLE: Transcriptional Regulation of Lung Cancer Identity

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: DC

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Hearing Loss;Neurosciences

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE Practice-based improvements in our ability to detect or discriminate subtle sound features – a process known as perceptual learning – is important for the development of speech and language, and for maximizing the benefits of hearing aids and cochlear implants. While non-sensory factors, such as attentional state or delivery of reward, are known to shape perceptual learning, we lack a comprehensive understanding of the neural mechanisms involved. The experiments proposed here will address this issue by assessing the contribution of one non-sensory brain region, the orbitofrontal cortex, and its descending projection to the auditory cortex to perceptual learning.

PI_NAMEs: CARAS, MELISSA LYNNE (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Anesthesia procedures;Animal Testing;Animals;Arousal;Attention;Auditory;Auditory area;Auditory system;autism spectrum disorder;Behavioral;Brain;Brain region;Calcium;calcium indicator;Clinical;Cochlear Implants;Cues;Data;design;Detection;Devices;Dyslexia;Electrodes;Electrophysiology (science);expectation;experimental study;Fiber;Frequencies;Gerbils;Goals;Hearing Aids;hearing impairment;Impairment;improved;in vivo;Individual;Language;Measures;Mediating;Methods;model organism;Monitor;Music;neural;neural circuit;Neurobiology;Neurodevelopmental Disorder;neuromechanism;Neurons;Noise;non-Native;optogenetics;Pathway interactions;Perception;Perceptual learning;pharmacologic;Photometry;Population;Prefrontal Cortex;Presbycusis;presynaptic;Process;Psychometrics;response;Rewards;Role;sensory cortex;Sensory Thresholds;Shapes;Signal Transduction;skills;sound;sound frequency;Speech;Speech Development;Speech Perception;speech recognition;Stimulus;Testing;therapy design;Time;tool;Training;Viral;Work

PROJECT_TITLE: Non-sensory Circuits for Auditory Perceptual Learning

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Neurodegenerative;Rehabilitation

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative  There is a lack of viable intervention strategies to alleviate the potential health risks of living alone with cognitive impairment (CI). This proposed R21 will develop and test the feasibility, acceptability, and usefulness of a home-based, seven-module intervention (“Home Alone”) to assist persons living alone with CI to successfully navigate the challenges of living independently. If successful, the proposed R21 will position Home Alone for a subsequent randomized controlled evaluation and later as a flexible, much-needed evidence-based resource that is scalable for healthcare systems and other dementia support providers.

PI_NAMEs: GAUGLER, JOSEPH E. (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Acute;Address;Adoption;Adult;Age;Age-associated memory impairment;Alzheimer's disease related dementia;Behavioral;Caregivers;Caring;Characteristics;Cognition;Collection;Communities;Complex;COVID-19 pandemic;Data;Data Element;Dementia;dementia care;design;Development;Diagnosis;Effectiveness;Elements;Enrollment;Environment;Evaluation;evidence base;experience;Family Caregiver;feasibility testing;Feeling;flexibility;Functional dependence;Goals;Health;Healthcare Systems;Home;home test;Hospitalization;Impaired cognition;implementation science;improved;Independent Living;indexing;Individual;innovation;insight;Institutionalization;instrumental activity of daily living;Intervention;Length;lens;Literature;Loneliness;Measures;Mental Health Services;Methods;mild cognitive impairment;Modeling;Morbidity - disease rate;novel;older adult;Older Population;Outcome;Participant;Persons;Phase;pilot test;Positioning Attribute;Process;programs;Provider;psychologic;Randomized;Recommendation;Research;Resources;response;Risk;Risk Factors;Services;social engagement;Social Well-Being;Stress;Supportive care;symposium;telephone based;Testing;theories;therapy design;therapy development

PROJECT_TITLE: Home Alone: Developing a Home-Based Intervention for People with Cognitive Impairment Who Live Alone

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Osteoporosis

ORG_CITY: PHILADELPHIA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: NARRATIVE The key to successfully treat prevalent skeletal disorders such as osteoporosis relies on understanding changes in the tissue associated with the observed reduced bone quality and increased fracture risk. Here, we propose a unique approach to investigate in clinical biopsies the complex relationship between multiple bone nanoscale compositional properties and typical histopathological and morphometric findings of osteoporotic bones. This innovative project will reveal valuable insights into the nanoscale origins of impaired bone health, contributing to elucidating osteoporosis pathogenesis and to inform future clinical studies into new therapeutic tissue targets to improve bone quality.

PI_NAMEs: QUERIDO, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: 3-Dimensional;Address;age related changes;aging population;artificial neural network;Biopsy;bone;Bone Density;bone fragility;bone health;bone quality;bone strength;Bone Tissue;Clinical;Clinical assessments;Clinical Management;Clinical Research;Collagen;Collagen Fibril;Complex;crystallinity;Data;Data Set;deep learning;Diagnosis;Disease;Elements;Evaluation;Fracture;fracture risk;Future;Goals;Heterogeneity;Histologic;Image;imaging system;Impairment;improved;Incidence;Individual;infrared spectroscopy;innovation;insight;Knowledge;Least-Squares Analysis;Machine Learning;machine learning method;markov model;meter;microCT;mineralization;Minerals;Modeling;Morphology;morphometry;nanoscale;Nature;novel therapeutics;Optics;Osteon;Osteoporosis;osteoporotic bone;Outcome;Outcomes Research;Pathogenesis;Performance;Persons;Pharmacotherapy;Play;Polishes;Polymethyl Methacrylate;Property;Public Health;recurrent neural network;Research;research study;Resolution;Role;Sampling;Scanning Electron Microscopy;skeletal disorder;Specificity;Spectroscopy, Fourier Transform Infrared;Standard Preparations;stoichiometry;Structure;submicron;Techniques;Tissues;Validation;X ray spectroscopy

PROJECT_TITLE: Multifactorial contribution of bone nanoscale composition to tissue quality in osteoporosis

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE Fluorescence guided surgery using the exogenous agent 5-ALA has been increasingly utilized to enhance the ability to detect residual tumor and improve the extent of resection for glioblastoma. As currently implemented, intensity-based detection by the surgeon viewing fluorescence through the operating microscope is non- quantitative and background light-sensitive, requiring the surgeon to work in a dark field. Our novel optical imaging FLIm system captures and analyzes tissue fluorescence quantitatively, and successful integration of this technology with existing stereotactic neuronavigation for spatial annotation of FLIm data and visualization is expected to generate a new tool for improved tumor detection and resection while overcoming the current limitations of 5-ALA use.

PI_NAMEs: BLOCH, ORIN  (contact);MARCU, LAURA ;VALCU, BOGDAN

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: Acids;Adjuvant;Adopted;Aminolevulinic Acid;Anatomy;Area;Augmented Reality;Biopsy;Brain;brain based;Brain Neoplasms;Brain region;brain tumor resection;Clinical;clinical application;Clinical Research;clinically significant;Computer software;Correlation Studies;Darkness;Data;Data Display;Detection;Disease;Emerging Technologies;Excision;FDA approved;Fiber;Fluorescence;fluorescence imaging;fluorescence lifetime imaging;fluorescence-guided surgery;Glioblastoma;Goals;Image;Imaging Device;imaging system;Imaging technology;improved;Infiltration;Light;Lighting;Location;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Manufacturer;Measurement;Measures;Metabolism;Methods;Microinvasive;Microscope;Monitor;Nature;neoplastic cell;Neuronavigation;neurosurgery;Neurosurgical Procedures;Newly Diagnosed;Normal tissue morphology;novel;Operative Surgical Procedures;optical imaging;Optics;Patient imaging;Patients;Pharmaceutical Preparations;Physiologic pulse;Positioning Attribute;Postoperative Period;Process;Prognosis;prospective;Prospective Studies;protoporphyrin IX;radiological imaging;Real-Time Systems;Resectable;Resected;Residual Neoplasm;Sampling;Scanning;Signal Transduction;software development;spatial integration;Surface;Surgeon;Surgical margins;Surgically-Created Resection Cavity;System;Techniques;Technology;Time;Tissues;tool;tumor;Tumor Burden;Tumor Tissue;virtual;Visual;Visualization;Work

PROJECT_TITLE: Integration of 5-ALA Fluorescence Lifetime Imaging with Stereotactic Surgical Navigation for Quantitative Real-Time Spatial Localization of Tumor During Neurosurgical Procedures


ORG_NAME: RHODE ISLAND HOSPITAL

PHR: Narrative Severe wrist osteoarthritis is exceedingly common, but the currently available treatments are much less successful than those available for hip, knee, or shoulder arthritis. The ability to advance novel technologies to the clinic requires data from fit-for-purpose large animal models, thus the goal of this proposal is to validate the Yucatan minipig as a preclinical, large animal model of the wrist. The Yucatan minipig wrist model will provide a critically needed tool for the rapid development of next-generation wrist implants and biologics for the treatment of severe wrist osteoarthritis.

PI_NAMEs: CRISCO, JOSEPH J (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 3-Dimensional;3D Print;Acute;Aftercare;Aging;aging population;Animal Model;Arthritis;Articulation;Biological Products;Biological Response Modifier Therapy;biomechanical test;Biomechanics;bone;Bone Spur;carpus bone;Cartilage;Clinic;Clinical;Data;Degenerative polyarthritis;design;Development;Device or Instrument Development;Devices;Disease;Dorsal;Failure;Family suidae;Future;Gait;Goals;Growth;Health;Hip region structure;Human;Implant;improved;In Vitro;in vitro Model;in vivo;Individual;innovation;Joints;kinematics;Knee;ligament injury;Ligaments;manufacture;Measurement;Measures;Methods;Miniature Swine;Modeling;Musculoskeletal;new technology;next generation;novel;novel therapeutics;Older Population;osteochondral tissue;Outcome;Outcome Measure;Pain;Pathology;Patients;pre-clinical;Pre-Clinical Model;primary outcome;Protocols documentation;Radial;Randomized;Replacement Arthroplasty;Research;Resort;Robotics;sample fixation;Scaphoid bone;secondary outcome;Severities;Shapes;Shoulder;Silicon;soft tissue;spatiotemporal;Study models;success;Surface;Survival Rate;Therapeutic;Thick;Time;Tissue Engineering;tool;Translations;Validation;Work;Wrist;wrist function

PROJECT_TITLE: Validation of the Yucatan Minipig as a Preclinical Model for Wrist Bone Arthroplasty

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative We currently do not understand the mechanisms that underlie the majority of congenital heart defects, which are the most common birth defects, or how to efficient repair injured hearts. This project will provide a greater understanding of the causes of congenital heart defects, normal heart development and regeneration. Ultimately, the information gleaned may allow the generation of novel therapies able to prevent congenital heart defects and regenerate injured hearts in children and adults.

PI_NAMEs: WAXMAN, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Ablation;Adult;Affect;Affinity Chromatography;apoAI regulatory protein-1;Arrhythmia;Atrial Function;Atrial Heart Septal Defects;Biological Assay;Buffers;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiogenesis;Cardiovascular Diseases;Cardiovascular system;Cells;Cessation of life;Child;Complex;Congenital Abnormality;Congenital Heart Defects;coronary vasculature;Coupled;CRISPR/Cas technology;Development;Diagnosis;Embryo;Embryonic Atrium;Embryonic Heart;Enhancers;Epicardium;Etiology;Family;Fatigue;Foundations;gain of function;Gene Expression Profile;Generations;Genes;Genetic Epistasis;genome editing;Genomics;Glean;Goals;Health;Heart;Heart Atrium;Heart Injuries;Heterogeneity;Human;human induced pluripotent stem cells;human stem cells;Hypertrophy;Immunoprecipitation;improved;In Vitro;in vivo;Individual;Infant Health;Infant Mortality;injured;Injury;injury and repair;Invaded;Knockout Mice;Knowledge;Life;loss of function;malformation;Mammals;Mediating;Metronidazole;Molecular;Monitor;mutant;Mutation;Natural regeneration;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;pharmacologic;Play;Population;posttranscriptional;premature;prevent;promoter;Proteins;Reagent;repaired;Repression;Ribosomes;Right ventricular structure;RNA;Role;scaffold;Signal Transduction;single-cell RNA sequencing;Sorting;stem cell fate specification;Stroke;targeted treatment;Testing;Tissues;Transcript;transcription factor;Transgenic Organisms;Translational Repression;Translations;Tretinoin;Untranslated RNA;Venous;Ventricular;vertebrate embryos;Vertebrates;WNT Signaling Pathway;Wounded area;Zebrafish

PROJECT_TITLE: Molecular Mechanisms of Atrial Development and Regeneration

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Infectious Diseases

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Narrative Apidaecin and Drosocin are antibacterial peptides produced by honeybees and fruit flies, respectively. They stop the growth of bacteria by exploiting a unique mechanism - inhibiting the termination step of protein synthesis. However, these antibiotics are active only against several bacterial species and many aspects of their action remain unknown. In the proposed project, we will expand the understanding of how this class of antibacterials achieve their inhibitory action on bacteria. We will expand the variety of antibacterial peptides that affect protein synthesis termination and broaden the spectrum of action of these unique antibiotics.

PI_NAMEs: MANKIN, ALEXANDER S (contact);MOORE, TERRY WILLIAM;POLIKANOV, YURY ;VAZQUEZ-LASLOP, NORA

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter baumannii;Affect;Amino Acid Sequence;Amino Acids;Anti-Bacterial Agents;anti-microbial peptide;Antibiotics;Bacteria;Binding;Biochemistry;Biological;Bypass;cell growth;Cells;Chemistry;Clinical;clinical development;clinically relevant;comparative;Complex;Data;design;Development;Drosophila genus;Escherichia coli;Event;fly;Future;Gene Library;Genome;Genomics;Goals;Gram-Negative Bacteria;Gram-Positive Bacteria;Growth;human pathogen;Hybrids;improved;infancy;Infection;inhibitor;Knowledge;Laboratories;Modeling;Nature;novel;pathogen;Penetration;peptide chemical synthesis;peptide drug;Peptide Synthesis;Peptides;Pharmaceutical Preparations;prevent;Proline;Property;Protein Biosynthesis;Protein Synthesis Inhibitors;Proteins;Publishing;rational design;Reagent;release factor;Research;Resolution;Ribosomes;Roentgen Rays;screening;Specificity;Staphylococcus aureus;Structure;Terminator Codon;Testing;therapeutic development;tool;Transfer RNA;Translational Repression;Translations;uptake;Variant;whole genome;Work

PROJECT_TITLE: Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Diabetes;Endocrine Disruptors;Genetics;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: HADLEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative Individuals may be predisposed to metabolic diseases like Type 2 diabetes as a result of the early life environment. Embryonic toxicant exposures can cause redox stress, disrupt developmental signaling pathways, and result in subtle structural or functional alterations to the insulin producing pancreatic β-cells. This project will use cell culture and zebrafish to provide an understanding of how embryonic exposure to chemicals like per-and- polyfluoroalkyl substances (PFAS) can damage the developing pancreas and insulin production, identify later-life functional impacts, and potential targets for mitigation.

PI_NAMEs: TIMME-LARAGY, ALICIA R (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Adolescent;Age;Age of Onset;Anabolism;Antioxidants;aqueous;Beta Cell;Biological Assay;Biological Markers;Biology;Cell Culture Techniques;Cell Death;Cell Maturation;Cell Physiology;Cells;cellular resilience;Characteristics;Chemical Exposure;chemical genetics;Chemicals;Clinical;Complex;Confocal Microscopy;Cysteine;Data;Defect;Development;developmental toxicology;Diabetes Mellitus;Disease;disorder risk;disulfide bond;Dose;Embryo;embryo cell;Embryonic Development;endocrine pancreas development;Environment;Environmental Exposure;epidemiology study;ethnic minority;Exposure disparity;Exposure to;Film;Fructosamine;Functional disorder;Funding;Future;genetic approach;Glutathione;Goals;Guidelines;Health;Health Policy;Human;Hybrids;Immunofluorescence Immunologic;Impairment;in vivo;Individual;Insulin;Intervention;islet;Laboratories;late life;Lead;Life;Link;malformation;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Modeling;mutant;Non-Insulin-Dependent Diabetes Mellitus;novel;Organogenesis;oxidation;Oxidation-Reduction;Oxidative Stress;Pancreas;Pathologic;persistent organic pollutants;Play;Poly-fluoroalkyl substances;Post-Translational Protein Processing;Prediabetes syndrome;Predisposition;prevent;Production;Proinsulin;Proteomics;Public Health;Publications;Publishing;Reactive Oxygen Species;receptor binding;Reporting;resilience;response;Role;Science;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stress;stressor;Structure of beta Cell of islet;Techniques;Testing;Time;Tissues;Toxic effect;toxicant;Toxicant exposure;transcription factor;Transcriptional Activation;Transgenic Organisms;Translating;Uncertainty;Variant;Work;Youth;Zebrafish

PROJECT_TITLE: Activation of Nrf2 during embryonic development - mechanisms and consequences

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(03)]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Impaired mitochondrial function is a point of convergence for numerous neurological, neurodevelopmental, and neurodegenerative disorders. In this proposal we investigate newly discovered long-lived mitochondrial proteins that persist for months in the mammalian brain. The proposed research will elucidate novel aspects of mitochondrial biology and new avenues of research into the processes of age-related neurodegeneration and beyond.

PI_NAMEs: BOMBA-WARCZAK, EWA KAROLINA (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: age related neurodegeneration;Aging;Amino Acids;Animals;Architecture;Axon;Biogenesis;Biology;Brain;Buffers;Calcium;Cell Death;Cell Physiology;Cells;Complex;Crista ampullaris;Dendrites;DNA;Docking;Energy-Generating Resources;experimental study;fitness;fluorescence imaging;Gene Expression;Gene Proteins;genetic manipulation;genome integrity;Goals;Half-Life;Heart;Homeostasis;Impairment;insight;Investigation;Kinetics;Label;Link;Longevity;Maintenance;Mass Spectrum Analysis;Measures;Membrane;Metabolic;Metabolism;Methods;Microfluidic Microchips;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial fitness;mitochondrial genome;Mitochondrial Proteins;Molecular;Molecular Target;Morphology;Mus;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuroglia;Neurons;novel;Nuclear;Nuclear Pore Complex;Optics;Organelles;Pattern;Phase;Physiologic pulse;Play;Positioning Attribute;postmitotic;preservation;Process;Production;Protein Biosynthesis;protein degradation;Proteins;Proteome;Proteomics;Quality Control;Rejuvenation;Research;Research Proposals;ribosome profiling;Role;Site;spatiotemporal;Stable Isotope Labeling;Stimulation of Cell Proliferation;Structure;superresolution microscopy;Synapses;Techniques;Tissues;Translations;Tubular formation;ultra high resolution

PROJECT_TITLE: Mitochondrial Fidelity in Mammalian Neurons


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Tissue repair and disease progression involve significant cellular flux and many molecular regulators controlling such cellular behavior remain unknown. Our proposed research uses the latest high-throughput genomics approaches to investigate gene control mechanisms that are often broadly modulated in intestinal tissue repair as well as malignancies, including colorectal cancer. Additionally, we develop novel methods to quantify molecular change in cells at unprecedented detail, which will help in development of novel disease prognosis methods and identification of novel targets for drug development.

PI_NAMEs: JADHAV, UNMESH  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Ablation;Abnormal Cell;Address;base;Binding;Biological Assay;Biological Process;bisulfite;Boranes;Cancer Etiology;cell behavior;Cell Nucleus;cell type;Cells;Cellular Assay;Cessation of life;Charge;Chemicals;Chromatin;Chromatin Structure;Cleavage Under Targets and Release Using Nuclease;Cluster Analysis;Colorectal;Colorectal Cancer;Complementary DNA;Computing Methodologies;Data;Development;Developmental Gene;Disease;disease prognosis;Disease Progression;DNA;DNA amplification;DNA analysis;DNA Damage;DNA Methylation;DNA Sequence Alteration;drug development;early onset colorectal cancer;Enhancers;Epigenetic Process;epigenomics;Epithelial Cells;Epithelium;Event;Evolution;Future;gastrointestinal;Gene Expression;Gene Expression Profile;Gene Mutation;Genes;Genetic;Genetic Transcription;Genome;Genomic approach;histone modification;innovation;intestinal epithelium;Intestines;Island;Knowledge;KRAS2 gene;magnetic beads;Malignant Neoplasms;Maps;Measures;Mesenchymal;Messenger RNA;Methods;Methylation;Modality;Modification;Molecular;multiple omics;Mutation;Natural regeneration;new therapeutic target;novel;preservation;Process;promoter;Proteins;Protocols documentation;Research;Resolution;RNA;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Sorting;Stains;stem cells;Technology;Testing;Therapeutic Intervention;therapy design;Time;tissue regeneration;tissue repair;Tissues;TP53 gene;transcription factor;transcriptomic profiling;tumor;tumorigenesis

PROJECT_TITLE: High resolution characterization of epigenetic dynamics in gastrointestinal cell plasticity


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma (PDAC) responds poorly to immunotherapy and the mechanisms of this resistance are unknown. We hypothesized that cancer-associated fibroblasts (CAFs) mediate this intratumoral immunosuppression in a HIF2-dependent fashion and provide evidence that HIF2 inhibition improves survival in mouse models of PDAC by potentially improving immune responses. In this grant, we explore the mechanisms of HIF2-dependent immune modulation by CAFs and perform preclinical studies to repurpose an FDA-approved HIF2 inhibitor to improve the response of pancreatic cancer to immunotherapy.

PI_NAMEs: KOONG, ALBERT  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Ablation;Animals;Biological Assay;blood perfusion;CD8B1 gene;Clinical;Clinical Research;clinical translation;Clinical Trials;Coculture Techniques;CRISPR/Cas technology;Data;Desmoplastic;effective therapy;Effector Cell;efficacy evaluation;Epithelium;Evaluation;FDA approved;Fibroblasts;Genetic Engineering;Genetic Transcription;Goals;Grant;Growth;Human;Hypoxia;hypoxia inducible factor 1;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immune system;Immune Targeting;Immunologics;immunomodulatory therapies;immunoregulation;Immunosuppression;Immunotherapy;improved;in vivo;inhibitor;innovation;Lymphocyte Activation;Macrophage;Macrophage Activation;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;Metabolic;Methods;Modeling;Molecular;Molecular Target;mouse model;Mus;Nutrient;Outcome;Oxygen;Pancreas;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;paracrine;paralogous gene;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;pre-clinical;preclinical study;recombinase;Regulatory T-Lymphocyte;Renal Cell Carcinoma;Research;resistance mechanism;response;Role;Signal Transduction;spatiotemporal;T cell regulation;T-Cell Proliferation;T-Lymphocyte;Temperature;Therapeutic;therapy resistant;translational potential;Translations;tumor;tumor growth;tumor-immune system interactions;Work

PROJECT_TITLE: The Role of HIF2 in Pancreatic Ductal Adenocarcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Traditional epidemiological research and methods often focus separately on how social, economic, and environmental factors affect individuals' life course health, yet evolving research underscores the importance of considering the integrated effects of factors that cluster in those who are most socially disadvantaged. While substantial research examines the developmental origins and biologic mechanisms underlying toxicant-health associations, few cohorts have the ability to address the intergenerational legacy of toxicant exposures and social structures on life course health. In the proposed application we will expand on our E3Gen cohort maintenance activities by utilizing data integration and analytical techniques to incorporate novel measures of social structure, economic indicators and ethnographic data into our biologic and data repositories for 550 original ELEMENT mothers, 600 of their young adult offspring aged 18-33 years, and establish passive surveillance to recruit their grandchildren currently and projected to be born over the next 5 years.

PI_NAMEs: PETERSON, KAREN EILEEN (contact);SONG, PETER XUEKUN

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Acceleration;Acculturation;Achievement;Address;Adolescence;Adult;Adult Children;Affect;aged;Air Pollution;allostatic load;American;Biological;Biometry;cardiometabolism;Chemical Exposure;Child;Childhood;cohort;Cohort Studies;Collaborations;college;Communities;Complex;Consumption;Data;Data Analytics;data communication;data harmonization;data infrastructure;data integration;data repository;data sharing;Degree program;design;Development;Diet;Dimensions;Disparity population;Diverse Workforce;drinking water;early life exposure;Economic Factors;economic indicator;Economics;Education;environmental disparity;Environmental Epidemiology;Environmental Exposure;Environmental Hazards;Environmental Health;environmental health disparity;environmental justice;Environmental Risk Factor;Epidemiologic Methods;Epidemiology;epidemiology study;ethnic minority;Ethnography;Exposure to;Family;Fatty Liver;follow-up;Food Packaging;Fostering;Future;Future Generations;Generations;Geography;grandchild;Health;Health behavior;health disparity;Heavy Metals;high risk;Household;Housing;improved;indexing;Individual;Inequality;Infrastructure;insight;intergenerational;Internships;Journals;Lead;lead exposure;Life;Life Cycle Stages;lifestyle factors;Literature;Lived experience;low socioeconomic status;Maintenance;marginalized community;Master of Science;Measures;Metabolic;Methods;Mexico;Michigan;Minority-Serving Institution;Modification;Mothers;Nature;Neighborhoods;Noise;non-alcoholic fatty liver disease;novel;offspring;Outcome;Participant;Pathway interactions;Pesticides;phthalates;Physical activity;Play;Population;Poverty;Pregnancy;prenatal exposure;prevent;Protocols documentation;Public Health;Qualitative Methods;racial minority;recruit;reproductive;Reproductive Health;Research;Research Infrastructure;Role;Schedule;Shapes;Sleep;social;Social Conditions;social disparities;social factors;social influence;social structure;Socioeconomic Status;socioeconomics;Source;stressor;student training;Students;Surveys;Techniques;Testing;Toxic Environmental Substances;toxicant;Toxicant exposure;Training;Training Activity;transition to adulthood;transmission process;undergraduate student;Universities;Vulnerable Populations;Weight;western diet;Work;young adult

PROJECT_TITLE: E3Gen: Multigenerational Influences of Social Structure on Toxicant Exposures and Life Course Health in the ELEMENT Cohort


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention

PHR: Project Narrative In this prospective multicenter observational study, we will collect clinical, EEG, and 2-year neurologic outcomes data for 3000 patients with acute brain injury, in order to validate three novel machine learning models for future use in clinical trials and clinical care: 1) a seizure forecasting model (“2HELPS2B”); 2) a model that predicts the effect of the Burden of Epileptiform Activity on Neurologic Outcomes (“BEACON”); 3) a model that uses properties of epileptiform EEG abnormalities in the acute phase of brain injury to predict the risk of developing chronic epilepsy. Deliverables will include a large, public database of high-quality EEG and clinical data on brain-injured patients with 2-year of outcomes data, and validated EEG tools to guide care and improve outcomes for patients recovering from acute brain injury.

PI_NAMEs: STRUCK, AARON F;WESTOVER, MICHAEL BRANDON (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: acquired epilepsy;Acute;Acute Brain Injuries;Address;Anticonvulsants;Artificial Intelligence;artificial intelligence model;Binding;Bioinformatics;bioinformatics infrastructure;Biological Markers;Black Box;Brain;brain electrical activity;Brain Injuries;care outcomes;Caring;Cerebrum;Cessation of life;Chronic;Chronic Phase;Clinical;clinical care;Clinical Data;Clinical Trials;clinically actionable;clinically significant;cohort;Collaborations;Computerized Medical Record;Critical Illness;Data;Data Collection;Databases;deep learning model;detector;Development;Electroencephalography;Epilepsy;epileptiform;Epileptogenesis;Equipoise;explainable machine learning;functional improvement;Future;General Hospitals;Geography;Guidelines;Hospitalization;Hospitals;Image;improved;improved outcome;Injury;large scale data;Learning;Long term disability;Machine Learning;machine learning algorithm;machine learning model;Massachusetts;Measures;Modeling;Monitor;multimodality;Neurological outcome;neurological recovery;neurophysiology;novel;Observational Study;Outcome;outcome prediction;Pathologic;Patient-Focused Outcomes;Patients;Pattern;Periodicals;Pharmaceutical Preparations;Phase;predictive modeling;prevent;Process;Prognosis;Property;prospective;Psychological reinforcement;public database;radiological imaging;Resources;Retrospective Studies;Risk;Risk Factors;risk prediction;Sample Size;Secondary Prevention;Seizures;signal processing;Site;Techniques;Time;tool;Translating;Uncertainty;Universities;Update;Validation;Wisconsin;Workload

PROJECT_TITLE: Prospective Validation of Neurophysiologic Outcome Prediction in Acute Brain Injury


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative The oral bacterium Porphyromonas gingivalis is one of the keystone pathogens associated with human periodontitis and other systemic illness such as diabetes, cardiovascular disease, arthritis, and Alzheimer’s disease. It produces an arsenal of virulence factors. Understanding the role of those virulence factors in the pathogenicity of P. gingivalis will ultimately lead to a new modality to prevent and treat periodontitis.

PI_NAMEs: LI, CHUNHAO CHRIS (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adherence;Alveolar Bone Loss;Alzheimer's Disease;Anabolism;antimicrobial;Arthritis;Bacteria;Binding;Binding Sites;Biochemical;Biochemistry;Biological;biological adaptation to stress;Biological Assay;Biological Markers;Biological Process;Biophysics;capsule;Carbon;Cardiovascular Diseases;Cell Communication;cell growth;Cell secretion;Cell surface;Cell Surface Receptors;Cells;Charge;chemokine;Clinical Research;Complement;complement system;Crystallography;Data;design;Development;Diabetes Mellitus;Diagnosis;dietary;Dose;Embryonic Development;Enzymes;Excision;experimental study;fitness;Forsythia;Functional disorder;Future;Genes;Genetic;genetic approach;Genome;Gingival Crevicular Fluid;Glycobiology;Glycoconjugates;Goals;Growth;gut bacteria;gut microbiome;Homologous Gene;Human;Immune;Immune Evasion;immune function;Immune system;Immunoglobulins;Immunology;immunoregulation;Impairment;In Vitro;in vivo;inhibitor;Innate Immune Response;insight;Intercept;interdisciplinary approach;Invaded;Kinetics;Ligands;Lipopolysaccharides;Macrophage;Maps;Measures;Mediating;Membrane Proteins;Microbial Biofilms;Modality;Molecular;mouse model;Mucins;Mucous Membrane;nano;Neuraminic Acids;Neuraminidase;Neurologic;neutrophil;novel;Nutrient;oral bacteria;Oral cavity;oral pathogen;Osteitis;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;patient response;Periodontal Diseases;Periodontitis;Phagocytosis;Phenotype;Play;polymicrobial biofilm;Polysaccharides;Porphyromonas gingivalis;Positioning Attribute;prevent;Proteins;Recommendation;Reporting;Resistance;response;Role;Salivary;Series;Severities;Shapes;sialic acid permease;Sialic Acids;sialylation;Side;structural biology;Structure;Substrate Specificity;Sugar Acids;Surface;Testing;Toll-like receptors;treatment response;uptake;Vagina;Virulence;Virulence Factors

PROJECT_TITLE: Dissecting the role of sialic acid and sialidase in the pathophysiology of Porphyromonas gingivalis


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: PROJECT NARRATIVE  Adenosine is an important neuromodulator that could provide neuroprotection during diseases, such as ischemia or traumatic brain injury, but little is known about the rapid mode of adenosine signaling to function during neuroprotection. Here, new technology is developed to allow measurements of multiple neuromodulators and neurotransmitters simultaneously. This technology is critical to understanding the rapid role adenosine plays in neuroprotection during stroke, and possibly developing therapies involving rapid adenosine release.

PI_NAMEs: VENTON, B. JILL (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TITLE: Multiplexed neurochemical methods to understand adenosine neuromodulation

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: Chronic pain is more prevalent and of greater intensity in Veterans than in the general population (VA Research on Pain Management Factsheet 2020). According to CDC, an estimated 25% (58 million) of U.S. adults have chronic pain. Chronic pain is highly prevalent in Veterans with nerve and spinal cord injury, traumatic limb amputation, burn injury, cancer, osteoarthritis, and peripheral neuropathy. There are also over 27,000 Veterans with SCI and related disorders including MS, who suffer from spasticity. Current treatments for chronic pain and spasticity are inadequate; they carry dose-limiting side effects and exert CNS side effects including the risk of abuse and addiction. Our research is aimed at developing better treatments for chronic pain and spasticity to substantially improve rehabilitation and quality of life of Veterans.

PI_NAMEs: DIB-HAJJ, SULAYMAN D;WAXMAN, STEPHEN  (contact)

PROJECT_TERMS: Acceleration;addiction;Adult;Affect;Afferent Neurons;Animal Model;Animals;Attenuated;Biological Markers;Burn injury;Cannabinoids;chemotherapy;Chondrocytes;chronic pain;chronic pain management;Clinical Research;Clinical Trials;Collection;Databases;Degenerative polyarthritis;Dendritic Spines;Development;Disease;Disease Progression;Dose Limiting;drug repurposing;Drug Screening;druggable target;experience;FDA approved;General Population;Generations;Genes;genetic risk factor;Goals;head-to-head comparison;high throughput screening;Horns;Human;human tissue;Implant;improved;Industry;Injury;innovation;Investments;Ion Channel;Legal patent;limb amputation;Malignant Neoplasms;Methods;Nerve;Nervous System Physiology;neurotransmission;novel;novel strategies;ocular pain;Pain;Pain management;pain reduction;pain signal;painful neuropathy;Pathway interactions;Patients;Peripheral Nervous System Diseases;Persons;Phantom Limb Pain;Pharmaceutical Preparations;Pharmacogenomics;pharmacologic;Pharmacotherapy;programs;Quality of life;Rehabilitation therapy;Research;resilience;Resolution;restoration;Risk;RNA Editing;side effect;spasticity;Spinal Cord;Spinal cord injury;stem cell technology;stem cells;success;technology platform;translational pipeline;Trigeminal Neuralgia;two photon microscopy;Vertebral column;Veterans;virtual reality;Visualization;Work

PROJECT_TITLE: Center for Restoration of Nervous System Function

STUDY_SECTION: RRDC

STUDY_SECTION_NAME: Centers, Research Enhancement Award Program and Consortiums[RRDC]


ORG_CITY: TUCSON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative: The length of time that antibodies persist after vaccination and infection and the efficacy of these antibodies against related pathogens varies widely. The goal of this proposal is to identify metabolic pathways that control the duration of immunity after vaccination.

PI_NAMEs: BHATTACHARYA, DEEPTA  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Ablation;Amino Acid Transporter;Amino Acids;Antibodies;Antibody Formation;Antibody-mediated protection;Biological;Bone Marrow;Carbon;Catabolism;Cell secretion;Cell Survival;cell type;Cells;Cellular biology;Chimera organism;Coupled;Cre driver;CRISPR screen;CRISPR/Cas technology;Data;differential expression;Energy Metabolism;Exocytosis;experimental study;extracellular;Funding;Gene Deletion;Genetic;Genetic Transcription;genome-wide;Glucose;glycosylation;Goals;Humoral Immunities;Immunity;Immunization;Immunoglobulins;in vivo;Infection;insight;interest;Length;life span;Link;mass spectrometric imaging;Measures;Mediator;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Morphology;Multiple Myeloma;Nutrient;pandemic disease;pathogen;Pathway interactions;Physiological;Plasma Cells;Resistance;response;Role;Shapes;Source;stable isotope;sugar;Surface;Testing;Time;tool;uptake;Vaccination;Vaccines;vacuolar H+-ATPase;Vesicle;Virus Diseases;Work

PROJECT_TITLE: Glucose and Amino Acid Catabolism in Plasma Cell Biology


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project Narrative Adrenoleukodystrophy (ALD) is a neurometabolic disorder that causes irreparable brain and spinal cord degeneration in both children and adults, with a wide spectrum of outcomes ranging from chronic disability to the total collapse of the brain’s major functions. The underlying cause for ALD is a defective break down of fatty acids which leads to an accumulation of fats that are deleterious to various tissues. I hypothesize that a nuclear receptor, Pparβ/δ, can be targeted to counterbalance multiple disease processes in ALD, and will determine how Pparβ/δ mitigates underlying disruptions in lipid metabolism in order to identify novel therapies in ALD.

PI_NAMEs: BARNES, JOSEPH ALEXANDER (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Adrenoleukodystrophy;Adult;Adverse effects;Aging;Agonist;alternative treatment;Animal Model;Atrophic;Attenuated;Binding;Biological Models;Bone Marrow Transplantation;Brain;brain cell;brain tissue;Cell Culture System;cell type;Cells;Central Nervous System;Cerebrum;Child;Cholesterol Homeostasis;Chronic disability;Clinical;Compensation;Complex;Cuprizone;Defect;Demyelinations;Deterioration;Development;Disease;Disease Progression;Disorder of neurometabolic regulation;Early Diagnosis;experience;Experimental Designs;Fatty acid glycerol esters;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Fiber;Functional disorder;Gene Targeting;Genes;Genetically Engineered Mouse;Hematopoietic Stem Cell Transplantation;Heterodimerization;high risk;Homeostasis;Immune;Immune response;Impairment;improved;Inborn Errors of Metabolism;Individual;Inflammation;Inflammatory;Injury;innovation;Innovative Therapy;insight;Intervention;Knowledge;Learning;lipid metabolism;Lipids;Maintenance;Mediating;member;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Methods;Microglia;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Molecular Target;mouse model;multiple datasets;Mutation;Myelin;Neonatal Screening;Nerve Fibers;neuroinflammation;novel;novel therapeutics;Nuclear Receptors;Oligodendroglia;Onset of illness;Organelles;Outcome;oxidation;Oxidative Stress;Pathway interactions;patient subsets;Patients;Penetrance;peroxisome;Peroxisome Proliferator-Activated Receptors;Phenotype;Physicians;Primary Cell Cultures;Process;Prognosis;Protein Isoforms;receptor;remyelination;Reporting;Role;Scientist;Secondary to;Signal Pathway;skills;Spinal Cord;stressor;Therapeutic;therapeutic target;Tissues;Training;Up-Regulation;Vegetative States;Very Long Chain Fatty Acid;Work

PROJECT_TITLE: Novel Role of Peroxisome Proliferator Activated Receptor Beta/Delta in X-Linked Adrenoleukodystrophy


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Emergency Care;Health Services;Heart Disease;Mental Health;Patient Safety;Prevention;Sleep Research

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Emergency department (ED) overcrowding and related factors during a patient’s stay increase their risk for cardiovascular disease (CVD) events and subsequent PTSD. The purpose of this research is to test whether modifiable ED factors increase CVD and psychological (burnout) risk in the millions of ED clinicians worldwide who are exposed to those same risk factors for years. If our hypotheses are supported, this research may motivate changes to EDs that offset CVD and psychological risk in clinicians, and may improve patient outcomes.

PI_NAMEs: CHANG, BERNARD P. (contact);SHECHTER, ARI

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;acute stress;Address;Age;behavioral cardiology;Blood Pressure;blood pressure elevation;Body mass index;burnout;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Chronic stress;Circadian desynchrony;cohort;Coronary heart disease;Crowding;Data;Depersonalization;design;Diné Nation;Disease Outcome;Emergency department crowding;Emergency Department Physician;Emergency Nursing;Emotional;Environment;Environmental Risk Factor;Event;exhaustion;Exposure to;follow-up;Health;heart disease risk;Hour;improved;innovation;Institute of Medicine (U.S.);Intervention;Link;Lipids;Mediating;Medical;Medical Errors;Mental disorders;Meta-Analysis;Nurses;Occupations;Participant;Pathway interactions;Patient Care;Patient risk;Patient-Focused Outcomes;Patients;Physicians;Physiological;Polysomnography;poor sleep;Post-Traumatic Stress Disorders;prospective;Provider;psychologic;psychological outcomes;Psychological Stress;Psychosocial Factor;Reporting;Research;Research Design;Restaurants;Risk;Risk Factors;Role;safety net;shift work;Sleep;Sleep disturbances;Smoking;Societies;Stress;stressor;Symptoms;System;Testing;Work;Workplace

PROJECT_TITLE: The Identification of Modifiable Emergency Department and Sleep Factors Contributing to Psychological and Cardiovascular Risk in Clinicians

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Precision Medicine;Rare Diseases

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE Our team has identified a potential treatment for hereditary neuropathy with liability to pressure palsies (HNPP). This discovery has prompted us to prepare for clinical trial. In this study, we will validate two potential monitoring biomarkers using human skin biopsy and quantitative magnetic resonance imaging, which may serve as primary or secondary outcome measures in HNPP clinical trial.

PI_NAMEs: CHEN, YONGSHENG  (contact);LI, JUN

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: Animal Model;Axon;Biological Assay;Biological Markers;biomarker development;Biopsy;Charcot-Marie-Tooth Disease;Clinical;Clinical Trials;clinically relevant;cohort;Data;deep learning;deep learning model;density;Dermal;detection method;disability;Disease;Disease Progression;Distal;Enrollment;Excision;Fatty acid glycerol esters;Fiber;Floor;functional outcomes;Genes;Goals;Hereditary neuropathy with liability to pressure palsies;Heterozygote;Human;Image;imaging modality;Imaging Techniques;indexing;Individual;inter-institutional;Intramuscular;Laboratories;Leg;Length;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;Mechanics;Methods;minimally invasive;Monitor;Motor;Muscle;Muscle denervation procedure;Muscle Weakness;Myelin;Myelinated nerve fiber;Nerve;nerve conduction study;Nerve Fibers;Nervous System Disorder;Outcome Measure;Output;Pathologic;Pathology;pathology imaging;Patients;Peripheral Nerves;Peripheral Nervous System Diseases;Permeability;pharmacologic;Phase;PMP22 gene;Polyneuropathy;preclinical study;primary outcome;Procedures;Process;Protons;rate of change;Relaxation;seal;secondary outcome;Sensory;serial imaging;Severity of illness;skin biopsy;small molecule;success;sural nerve;System;Testing;Thigh structure;Time;translational potential;treatment effect

PROJECT_TITLE: Biomarker development in patients with HNPP

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE The overarching research focus of the Wake Forest Translational Alcohol Research Center (WF-TARC) is to study behavioral correlates associated with heightened vulnerability to alcohol use disorder and identify neurobiological adaptations responsible for these behaviors. The highly integrated experimental design of this renewal continues to leverage the unique benefits of rodent, nonhuman, and human subjects research and facilitates backward and forward translation between projects. Collectively, these studies may lead to novel therapeutic interventions for individuals at greatest risk of developing alcohol alcohol use disorder.

PI_NAMEs: WEINER, JEFFREY L. (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Acceleration;addiction;Adolescent;alcohol abuse therapy;Alcohol consumption;alcohol research;alcohol use disorder;Alcohols;Animal Model;Animals;Award;Behavior;Behavioral;behavioral study;Biometry;Brain;Collaborations;Communication;Community Health Education;Development;Diagnosis;Disease;drinking behavior;Education;Education and Outreach;educational atmosphere;effective therapy;Ensure;evidence base;Experimental Designs;Faculty;Funding;Goals;Grant;Growth;Healthcare Systems;Human;human model;Human Subject Research;improved;Individual;Infrastructure;innovation;Institution;Knowledge;Leadership;Learning;Measures;medical schools;Methods;Molecular;morphogens;multidisciplinary;neural;neural correlate;Neurobiology;neurodevelopment;next generation;nonhuman primate;novel;novel strategies;novel therapeutic intervention;Pilot Projects;Play;Population;Populations at Risk;Postdoctoral Fellow;Pre-Clinical Model;predictive modeling;Productivity;programs;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Support;resilience;Resources;Risk;Rodent;Role;Science;Sleep disturbances;Students;Substance Use Disorder;success;System;Talents;training opportunity;Translational Research;translational therapeutics;Translations;Treatment outcome;Work


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Substance Misuse

PROJECT_TERMS: addiction;Address;alcohol abuse therapy;Alcohol consumption;alcohol research;alcohol use disorder;Alcohols;Awareness;Behavioral;Behavioral Mechanisms;behavioral study;Biometry;Collaborations;Communities;Complement;Disease;Education and Outreach;Ensure;Environment;experience;Faculty;Funding;Goals;Health Personnel;Healthcare Systems;Human;human subject;Human Subject Research;improved;Infrastructure;innovation;Institution;Knowledge;Leadership;Learning;Medical center;medical schools;Mission;Modeling;Monkeys;neural;neurobiological mechanism;Neurobiology;nonhuman primate;novel;novel therapeutic intervention;organizational structure;outreach;Pilot Projects;Population;Postdoctoral Fellow;Productivity;programs;Public Health;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Research Training;resilience;Rodent;Services;Students;Substance Addiction;substance use;success;Training Activity;training opportunity;Training Programs;Translational Research;translational study;treatment strategy;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: LOUISVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 and has resulted in ongoing pandemic, tragic loss of life, and dire economic consequences. COVID-19 patients with severe and critical disease also develop pulmonary inflammation and abnormal bleeding problems. We propose to study the mechanisms underlying these problems and develop a novel therapeutic approach; this will help us achieve rapid progress toward overcoming the challenges of COVID-19.

PI_NAMEs: HUANG, JIAPENG ;URIARTE, SILVIA M;YAN, JUN  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: 2019-nCoV;Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Age;Antibodies;antimicrobial;Bilateral;Blood;Blood Coagulation Disorders;Blood Platelets;Bronchoalveolar Lavage Fluid;Cells;chemokine;Chemotaxis;Circulation;Clinical;Collaborations;COVID-19;COVID-19 patient;COVID-19 vaccine;COVID-19/ARDS;cytokine;cytokine release syndrome;Cytometry;Cytoplasmic Granules;Data;density;Development;Disease;Disease Progression;Economics;effective therapy;emerging virus;Exocytosis;extracellular;FCGR3B gene;Fibrin fragment D;Functional disorder;Gene Expression;Hemorrhage;Heterogeneity;Hospitalization;Host Defense;Immune;immune activation;immunothrombosis;In Vitro;in vivo;Individual;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;insight;Intensive Care Units;Interleukin-6;Life;Lung;lung injury;Lymphocyte;Measures;mouse model;multiple omics;Myeloid-derived suppressor cells;neutrophil;Neutrophil Infiltration;novel;novel marker;novel therapeutic intervention;Outcome;pandemic disease;pathogenic virus;Patient Transfer;Patients;Pattern;Personal Satisfaction;Phagocytosis;pharmacologic;Plasma;Platelet Activation;Pneumonia;Population;post SARS-CoV-2 infection;prospective;Proteome;Proteomics;Psyche structure;Pulmonary Inflammation;Reactive Oxygen Species;Reporting;Respiratory Burst;response;Role;severe COVID-19;Severity of illness;sex;Surface;System;systemic inflammatory response;T-Lymphocyte;Therapeutic Intervention;therapeutic target;therapeutically effective;tissue injury;TNF gene;transcriptome sequencing;transcriptomic profiling;transcriptomics;Variant;Viral

PROJECT_TITLE: Neutrophil Heterogeneity and Immunopathogenesis of COVID-19 ARDS

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Rare Diseases;Spina Bifida

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Proper shaping of the brain and spinal cord is driven by highly coordinated cell movements during early embryonic development. Disruptions in this process can result in neural tube defects such as spina bifida, but the signals that control cell movements within the future neural tube are poorly understood. The proposed research will use zebrafish embryos as a model to identify novel regulators of cell movements that shape the developing neural tube.

PI_NAMEs: EMIG, ALYSSA NICOLE (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Affect;Anencephaly and spina bifida X linked;Anterior;Automobile Driving;Behavior;Blastoderm;brain shape;Candidate Disease Gene;Cell Communication;cell motility;Cells;Childhood;chordin;Complex;Congenital Abnormality;constitutive active receptor;Coupled;Data;Development;Embryo;embryo cell;Embryonic Development;Endoderm;Ensure;Event;Future;gastrulation;gene function;Genes;Genetic;Genetic Transcription;Germ Layers;in vivo;in vivo Model;Individual;innovation;Intercalated Cell;knock-down;Knowledge;Ligands;Literature;loss of function;Mesoderm;Modeling;Morphogenesis;morphogens;mortality;Neural Fold;Neural tube;Neural Tube Closure;Neural Tube Defects;Neuroectoderm;Nodal;novel;optogenetics;Organism;overexpression;Play;polarized cell;Pregnancy;Prevalence;Process;programs;receptor;Regulation;Research;response;Role;Series;Severities;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;Specific qualifier value;Spinal Cord;Spinal Dysraphism;Spontaneous abortion;Techniques;Testing;Time;Tissues;transcriptome sequencing;Transgenic Organisms;vertebrate embryos;Vertebrates;Zebrafish

PROJECT_TITLE: Regulation of neuroectoderm morphogenesis by Nodal signaling programs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative Endogenous opioids control neuronal excitability at circuits throughout the brain, and may provide a mechanism for limiting excitation in the hippocampus, specifically in the epileptic brain. Here, I aim to characterize the impact of endogenous release of opioid peptides on brain network function. The proposed experiments will improve our understanding of the influence of endogenous opioids on hippocampal circuits, and possibly lead to improved epilepsy management.

PI_NAMEs: WARIKOO, NATASHA  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: abuse liability;Acute;Adult;Affect;Analgesics;Anticonvulsants;Attenuated;Behavior;Binding;Biological Assay;Biosensor;Brain;brain tissue;cell type;Cells;Characteristics;Communities;Competence;Complement;Data;designer receptors exclusively activated by designer drugs;Development;Disease;Drug Modulation;Dynorphins;Educational process of instructing;Electrophysiology (science);endogenous opioids;Enkephalins;Epilepsy;epileptiform;Epileptogenesis;Experimental Designs;experimental study;Faculty;Fluorescence;Funding;Future;Gene Modified;Goals;granule cell;GTP-Binding Proteins;Hippocampus;Homeostasis;improved;in vitro Assay;in vivo;Inhibitory Synapse;insight;Interneurons;Kainic Acid;Knowledge;Lead;Leadership;Ligands;Light;light effects;Manuscripts;Measures;Mediating;Medicine;Mentorship;Modeling;mossy fiber;mouse genetics;mouse model;Mus;neural circuit;neuronal circuitry;neuronal excitability;Neurons;neurotransmitter release;novel;Opioid;Opioid Peptide;Opioid Receptor;optogenetics;Pain;patch clamp;Pathway interactions;Pentylenetetrazole;Peptide Signal Sequences;Peptides;Performance;Pharmaceutical Preparations;Pharmacogenetics;pharmacologic;Physiologic pulse;Physiology;postsynaptic;Potassium;Predisposition;presynaptic;Probability;Property;Pyramidal Cells;receptor;Research;response;Rewards;Role;Scientist;Seizures;selective expression;Signal Transduction;skills;Slice;spatiotemporal;Specificity;Stimulus;Synapses;System;Technology;Therapeutic;Time;tool;Training;Translational Research;transmission process;Viral;Visualization;Whole-Cell Recordings;Work;Writing

PROJECT_TITLE: Functional roles of endogenous opioid peptides in hippocampal circuitry


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Mental Health;Neurosciences;Rehabilitation

ORG_CITY: BERKELEY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative The purpose of this research is to discover how neural circuits in the auditory cortex perform the sound to meaning transformation for the sounds used in vocal communication. This research will be useful for designing the next generation of hearing aids and cochlear implants and will allow us to understand the causes of some learning disabilities and mental disorders that involve high-level auditory processing, including deficits in speech comprehension and other cognitive abilities.

PI_NAMEs: THEUNISSEN, FREDERIC E. (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Affect;Anatomy;Animal Model;Animals;Area;Auditory;Auditory area;Auditory Perception;auditory processing;Auditory system;Behavior;Behavioral;Biological Models;Birds;Categories;Cochlear Implants;cognitive ability;cognitive skill;Communication;Complex;Comprehension;Computer Analysis;Computing Methodologies;Data;Databases;design;Detection;Development;Discrimination;experimental study;Fathers;Goals;Hearing Aids;Human;Hunger;Individual;Knowledge;Laboratories;Learning;Learning Disabilities;Lesion;Location;Mediating;Memory;Mental disorders;Methods;Modeling;Nature;neural;neural circuit;neural prosthesis;neuroethology;Neurons;neurophysiology;next generation;non-linear transformation;novel;Operant Conditioning;Partner in relationship;Performance;Pitch Perception;Play;Positioning Attribute;Process;Research;response;Role;semantic processing;Semantics;Series;signal processing;Signal Transduction;social;social attachment;Songbirds;sound;Sound Localization;Source;Speech;speech processing;speech recognition;Stress;System;Testing;vocalization;Voice;Work;zebra finch

PROJECT_TITLE: Auditory Circuits for Interpreting Vocal Communication Signals


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Substance Misuse

PI_NAMEs: HANLON, COLLEEN A (contact)

PROJECT_TERMS: Address;Alcohol consumption;alcohol research;alcohol use disorder;Alcohols;Applications Grants;Area;Award;base;Behavioral;career development;Collaborations;Communities;Community Medicine;Complement;Critiques;Data;Elements;Evaluation;Evolution;Extramural Activities;Faculty;Funding;Future;Goals;Healthcare Systems;human subject;innovation;insight;Institution;interest;Lead;medical schools;meetings;member;Mentors;Methods;Minority Groups;Monkeys;Mus;neural;new technology;nonhuman primate;Pilot Projects;Process;Productivity;programs;Progress Reports;Qualifying;Rattus;Request for Applications;Research;Research Personnel;resilience;Resources;Rodent;Scientist;success;Technical Expertise;Techniques;Technology;Training Support;Translational Research;Underrepresented Minority;Voting;Work

PROJECT_TITLE: Pilot Projects Core