NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Alcohol use disorders are major public health problems in most parts of the world including the United States. This request is for funding to allow young scientists to attend the 44th through 48th Annual Meeting of the Research Society on Alcoholism (RSA). The meeting outcome will greatly advance the treatment, prevention, and understanding of alcoholism in the U.S. and throughout the world, and it will also help to retain trainees and young investigators in the field.

PI_NAMEs: NIXON, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TITLE: SUPPORT FOR THE ANNUAL MEETING FOR THE RESEARCH SOCIETY ON ALCOHOLISM (RSA)

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVES This research project focuses on studying the role of bilingualism in cognitive reserve through three socio- demographically and linguistically diverse cohorts: Chinese Americans, Mexican Americans, and Indians. in this project, the University of California, San Francisco, the National Institute of Mental Health and Neuroscience, and the Health and Aging Brain-Health Disparities study joint effort to assemble one of the largest, multicultural, multilingual, and well-characterized cohort of 2,200 individuals to build a theoretical framework for bilingualism and cognitive reserve. The proposed work will enhance our understanding of the multidimensionality of bilingualism and offer valuable insights into the inter-relationships of bilingualism, social determinants of health, and cognitive reserve.

PI_NAMEs: ALLADI, SUVARNA ;BABULAL, GANESH M;O'BRYANT, SID E;TEE, BOON LEAD  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Accounting;Address;Age;Age of Onset;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Amyloid beta-42;Anterior;Attention;bilingualism;Biological;Biological Markers;Brain;Brain Pathology;California;Cerebrum;Chinese;Chinese American;Chronic stress;Cognition;Cognitive;cognitive performance;cognitive reserve;cohort;Corpus Callosum;Correlation Studies;Data;Dementia;dementia risk;design;Diagnostic;Dimensions;Education;English Language;Ethnic Population;executive function;experience;Factor Analysis;follow-up;Frequencies;Functional Magnetic Resonance Imaging;Glial Fibrillary Acidic Protein;Goals;Health;health care availability;health disparity;health disparity populations;healthy aging;Image;imaging biomarker;Impaired cognition;improved;India;Individual;insight;Investigation;Joints;Language;Language Development;Learning;lens;Light;Linguistics;Link;Longitudinal cohort;Measures;Mexican Americans;mild cognitive impairment;molecular marker;Multilingualism;National Institute of Mental Health;neighborhood disadvantage;neural;Neurocognitive;neurofilament;neuromechanism;Neurosciences;novel;Outcome;Persons;Population;Population Heterogeneity;Population Study;Prevalence;protective effect;Publishing;racial population;Research;Research Project Grants;resilience;Role;San Francisco;Series;Severity of illness;social culture;social health determinants;sociocultural determinant;sociodemographics;Socioeconomic Status;Spanish;stem;study population;tau Proteins;Texas;Universities;Visit;Work;Writing

PROJECT_TITLE: The impact of bilingualism on cognitive reserve/resilience using socio-demographically and linguistically diverse populations


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: DALLAS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative The project described here studies a unique cellular pathway used by influenza virus mRNAs to be exported from the nucleus to the cytoplasm. This project will also examine the effect of a novel inhibitor of this process, which prevents viral replication without causing cell toxicity. Thus, these studies will reveal fundamental biology and may uncover a potential strategy for drug development.

PI_NAMEs: FONTOURA, BEATRIZ MA (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Affect;Anti-viral Agents;Anti-viral Response;antiviral drug development;Binding;Binding Proteins;Binding Sites;Biochemical;Biological Assay;Biology;Cell Nucleus;Cell Physiology;Cells;Cellular biology;cellular targeting;Chemicals;Complex;Cytoplasm;Data;design;Docking;drug development;Exhibits;Future;Gene Expression;Genes;Genetic;Genomic approach;Image;imaging approach;Immunity;In Vitro;Infection;Influenza;Influenza A virus;influenzavirus;inhibitor;Knock-out;Label;Lead;Life Cycle Stages;Mediating;Messenger RNA;Molecular;Molecular Genetics;mRNA Export;Mutagenesis;novel;Nuclear;Nuclear Export;Nuclear Pore Complex;Nuclear Pore Complex Proteins;overexpression;Pathogenesis;Pathway interactions;phosphoproteomics;Phosphotransferases;Poly(A)+ RNA;prevent;Process;Proteins;Publishing;receptor;Recombinants;Regulation;Reporting;RNA;single molecule;small molecule;small molecule inhibitor;Structure;System;Toxic effect;Validation;Viral;Viral Genes;Viral Genome;Viral Proteins;Virulence Factors;Virus;Virus Inhibitors;Virus Replication

PROJECT_TITLE: Virulence Factor at the Interface of Viral and Cellular mRNA Nuclear Export

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Cerebrovascular;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Spinal Cord Injury (SCI) represents a major health crisis that leaves hundreds of thousands of people worldwide paralyzed or otherwise unable to perform essential daily functions, including walking, reaching, grasping and urination. While the body does have some potential for regeneration and recovery after SCI, the factors governing this regenerative capacity remain poorly understood, but prior work has found that recovery can correlate with the formation of new blood vessels in the spinal cord. My proposed research will directly address the potential of a novel astrocyte subtype to aid in the formation of new blood vessels in the spinal cord after injury- opening novel therapeutic avenues aimed at providing a more hospitable intraspinal environment to bolster functional recovery after SCI.

PI_NAMEs: SURESH, KESHAV BALAJI (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Address;Adhesions;angiogenesis;Astrocytes;Automobile Driving;Axon;axon regeneration;axonal sprouting;Behavioral;Behavioral Assay;Biological Process;Blood - brain barrier anatomy;Blood flow;Blood Vessels;blood-brain barrier function;Brain;career;Cell Proliferation;Cells;Central Nervous System;central nervous system injury;central nervous system vasculature;Characteristics;Complement;conditional knockout;daily functioning;Data;Data Set;design;Development;Dimensions;Distal;Dryness;Endothelial Cells;Endothelium;Environment;Evaluation;Evolution;Family member;Gene Expression;Genes;Genetic Transcription;gliovascular;Goals;grasp;Health;high dimensionality;Histologic;Histology;Homeostasis;Hybrids;Hypoxia;in silico;In Vitro;in vivo;Injury;innovation;Integrins;Ischemia;ITGB3 gene;Knockout Mice;Lateral;Lesion;Life;Ligation;Link;Literature;Location;Locomotor Recovery;loss of function;Maintenance;Mediating;Methods;Modeling;Molecular;Molecular Evolution;Morphology;motor recovery;mouse model;Mus;Nervous System Disorder;Nervous System Physiology;Neurons;notch protein;novel;novel therapeutics;Paralysed;Pathology;Pericytes;permissiveness;Persons;Phenotype;Physiological;Positioning Attribute;Process;programs;Proliferating;Recovery;Recovery of Function;regeneration potential;regenerative;Regenerative capacity;Regulation;Research;Research Personnel;Research Training;Resources;restoration;Role;Signal Transduction;Site;spatiotemporal;Specific qualifier value;Spinal;Spinal Cord;Spinal cord injury;Stroke;Technology;Testing;Therapeutic;timeline;Tissues;Training;transcriptomics;Transgenic Mice;translational neuroscience;Up-Regulation;Urination;Vascular remodeling;Walking;white matter;Work

PROJECT_TITLE: Interrogating the Potential of Ccn1+ Astrocyte Niches to Drive Angiogenesis after Spinal Cord Injury


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Circadian clocks have a profound impact on human health as they play a central role in regulating daily physiology, and several studies indicate substantial correlation between circadian dysfunction (e.g. in shift work) and human diseases including cancers, heart disease, lung inflammation, diabetes, metabolic, vascular and mental disorders. This project's goal is to study new types of circadian rhythms in mice that are missing a key molecular component of the core clock machinery – a gene called Bmal1. Gaining new molecular insights into the circadian clockwork will guide future therapeutic interventions to alleviate the disorders associated with circadian disruption, which are highly prevalent in contemporary society.

PI_NAMEs: REDDY, AKHILESH BASI (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Affect;ARNTL gene;Automobile Driving;Behavior;Behavioral;Binding;Biochemical;Cardiovascular Diseases;Cell Physiology;Cells;ChIP-seq;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Clock protein;Clustered Regularly Interspaced Short Palindromic Repeats;Data;desthiobiotin;Diabetes Mellitus;Disease;Erythrocytes;ETS Family Protein;experimental study;Family;Feedback;Fibroblasts;Future;Genes;Genetic Transcription;Genome;Genomics;Glucose;Glycolysis;Goals;Health;Heart Diseases;Hour;Human;human disease;Immunoprecipitation;insight;Investigation;Knock-out;Knockout Mice;Life;Liver;Maintenance;Malignant Neoplasms;Mammals;Maps;Mass Spectrum Analysis;Measures;Mediating;Mental disorders;Metabolic;Metabolic Diseases;Metabolism;Methods;Modeling;Molecular;molecular clock;molecular modeling;Mus;novel;Nuclear;Organism;Output;Oxidation-Reduction;Pathway interactions;Pattern;Pentosephosphate Pathway;Periodicity;peroxiredoxin;Phase;Phosphorylation;Phosphotransferases;Physiological;Physiology;Play;posttranscriptional;Predisposition;Process;programs;Proteins;Proteome;Proteomics;Pulmonary Inflammation;recruit;Regulation;Reporting;Research;Role;shift work;Skin;Societies;System;Testing;Therapeutic Intervention;Time;Tissue Sample;Tissues;Transcript;transcription factor;Transcription Process;transcriptome;Translations;Vascular Diseases;virtual

PROJECT_TITLE: Mechanistic Basis of Circadian Clocks in Bmal1 Knockout Mice

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Immunotherapy;Lung;Lung Cancer

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Adenovirus (Ad) is a remarkably efficient virus at infecting and replicating in human cells. These properties made adenovirus-based vectors a highly attractive platform for developing novel therapeutics to combat genetic diseases and cancer. The successful completion of this project will significantly advance our understanding of fundamental factors that are critical for effective clinical translation of Ad-based vector systems as cancer therapeutics. Results of our work may also be broadly applicable to other oncolytic viral vector systems and other treatment modalities that aim at triggering potent tumor cytotoxicity to halt progression and/or promote immunity to localized and disseminated neoplastic disease.

PI_NAMEs: SHAYAKHMETOV, DMITRY  (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: A549;Acceleration;adaptive immunity;Address;Adenovirus Vector;Adenoviruses;Affect;Animal Model;Animals;anti-tumor immune response;Antigen-Antibody Complex;Applications Grants;Automobile Driving;cancer cell;Capsid;CD8-Positive T-Lymphocytes;Cell Compartmentation;cell killing;Cell Physiology;cell stroma;Cells;clinical translation;Clinical Trials;clinically relevant;combat;cytokine;Cytometry;cytotoxic;cytotoxicity;Data;design;Development;Dimensions;Disease;Dose;drug candidate;Drug Targeting;Environment;exhaustion;Family;Flow Cytometry;Generations;Genetic Diseases;genetic regulatory protein;Growth Factor;Human;Human Cell Line;Immune;Immune response;Immunity;Immunologic Markers;Immunosuppression;improved;In Vitro;in vivo;Infiltration;Interleukin-1;Intravenous;Isotope Labeling;Kupffer Cells;Lung Neoplasms;Lymphoid Cell;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mesocricetus auratus;Metals;Modality;Modeling;Molecular;mouse model;Mus;Mutagenesis;Mutation;Myeloid Cell Activation;Myeloid Cells;neoplastic;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Nude Mice;Oncolytic;Outcome;patient derived xenograft model;PD-1 pathway;pharmacologic;Phenotype;Play;Population;Predisposition;programmed cell death ligand 1;programmed cell death protein 1;Property;response;Rodent;Role;Route;Safety;Signal Transduction;single-cell RNA sequencing;Site;species difference;System;Therapeutic;Time;tissue repair;translational medicine;Translational Research;Transplantation;Treatment Efficacy;tumor;Tumor Biology;tumor growth;tumor progression;Tumor Promotion;Tumor-Derived;tumorigenic;Variant;vector;Viral;Viral Vector;Virotherapy;Virus;Work;Xenograft Model

PROJECT_TITLE: Mechanistic factors limiting utility of adenovirus vectors for treatment of neopla

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Kidney Disease;Rare Diseases

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: ‐ ‐‐ This project addresses unmet needs in our understanding of primary membranous nephropathy (MN) mechanism of initiation and progression. Using a newly generated glomerulus on a chip system that mimics the renal filtration barrier in vitro, we gathered preliminary data hinting at a possible role of the C3a/C3aR  ‐ signaling in podocyte and glomerular endothelial injury. We will test our hypothesis in vitro and in vivo and the results generated by this project will be directly relevant to the better understanding of auto immune nephropathies and other proteinuric kidney diseases.

PI_NAMEs: DA SACCO, STEFANO  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Address;Adult;Albumins;Animals;antagonist;Antibodies;Antigens;Autoantibodies;Basement membrane;Cell Communication;cell injury;Cells;Characteristics;Clinical;Complement 3a;Complement 3d;Complement Activation;complement C3 precursor;Complement Inactivators;Complement Membrane Attack Complex;Cytoskeleton;Data;Deposition;Development;Disease;Disease remission;Endothelial Cells;Endothelium;experimental study;Exposure to;Extravasation;Filtration;Functional disorder;Future;glomerular basement membrane;glomerular endothelium;glomerular filtration;Glomerulonephritis;glomerulosclerosis;Human;human disease;Immune;Immunoglobulin G;Impairment;In Vitro;in vivo;Injury;Intervention Trial;Inulin;Kidney;Kidney Diseases;Kidney Failure;Knockout Mice;MAP Kinase Gene;Mediating;Membrane;Membranous Glomerulonephritis;MMP9 gene;Modeling;Modification;Molecular;Multiple Trauma;Mus;Nephrotic Syndrome;NF-kappa B;novel;overexpression;Pathogenesis;Pathway interactions;Patients;Permeability;pharmacologic;Pharmacologic Substance;Phenotype;Phospholipase A2;Placebos;Play;podocyte;pre-clinical;prevent;Production;Proteins;Proteinuria;Randomized, Controlled Trials;Rattus;receptor;Receptor Signaling;renal damage;Role;Serum;Signal Transduction;slit diaphragm;Snails;System;Testing;therapeutic target;Thrombospondins;tool;translational study;urinary;Work

PROJECT_TITLE: Novel mechanisms of glomerular injury in primary membranous nephropathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-H(04)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Lung cancer is the leading cause of cancer death among veterans; the lack of effective therapy provides the impetus to search for alternative, anti-neoplastic, chemopreventive agents and treatment strategies. Grape seed procyanidin extract (GSE) is used to promote cardiovascular health, and milk thistle silymarin extract (MTE) is used to promote hepatobiliary health; both natural agents have independently been reported to exert anti-neoplastic effects against lung cancer. Based on our encouraging in vitro findings showing unequivocal synergistic anti-cancer effects exerted by the combinations of GSE and MTE, the purpose of this continuing renewal Merit Review proposal is to evaluate the in vivo anti-neoplastic properties of combinations of leucoselect phytosome and siliphos, which are standardized GSE and MTE complexed with soy phospholipid to enhanced bioavailability, in mouse models of lung cancer, to determine their pharmacokinetics and pharmacodynamics against lung cancer, identify suitable surrogate endpoint biomarkers and set the stage for clinical trials in the near future.

PI_NAMEs: MAO, JENNY T (contact)

PROJECT_TERMS: A549;Aftercare;anti-cancer;Anti-tumor Natural Products;Antineoplastic Agents;Antioxidants;Apoptosis;Apoptotic;Biological Availability;Biological Markers;Biological Models;BIRC5 gene;Blood;bronchial epithelium;cancer biomarkers;cancer cell;Cancer cell line;cancer chemoprevention;Cancer Etiology;cardiovascular health;Cardiovascular system;CASP3 gene;Cell Line;Cells;Cessation of life;Chemical Structure;Chemopreventive Agent;Clinical;Clinical Trials;Coculture Techniques;Collection;Complex;Data;Dose;Drug Kinetics;effective therapy;Eicosanoids;Engraftment;Epigenetic Process;Epithelial Cells;FHIT gene;Food Supplements;Freezing;Future;Gene Chips;Gene Expression;Gene Expression Profile;grape seed;Growth;Health;Health Food;Hepatobiliary;Human;IGF2R gene;improved;In Vitro;in vivo;indexing;Induction of Apoptosis;inflammatory marker;Inhibition of Cell Proliferation;insight;Interleukin-10;Interleukin-12;Interleukin-6;Invaded;Lung;lung cancer cell;lung cancer prevention;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Malignant Neoplasms;Maximum Tolerated Dose;Measures;Mediating;MicroRNAs;Milk Thistle;Milk thistle extract;Molecular;Monitor;mouse model;Mus;neoplastic cell;novel;Nude Mice;Oral;Oral Administration;Organ;Outcome;Pathway interactions;patient derived xenograft model;Patients;Personal Satisfaction;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phase;Phospholipids;Physiological;Plasma;polyphenol;Pre-Clinical Model;predicting response;Premalignant Cell;Prevention trial;Procyanidins;Proliferating;Property;PTEN gene;Reporting;Sampling;Signal Pathway;Silymarin;Site;soy;Standardization;Structure of parenchyma of lung;Surrogate Endpoint;Surrogate Markers;System;Testing;Time;TP53 gene;Translating;treatment duration;treatment group;treatment response;treatment strategy;tumor growth;Tumor Immunity;Tumor Volume;tumor xenograft;Veterans;Water;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Combinations of Grape Seed and Milk Thistle Extracts Against Lung

STUDY_SECTION: ONCB

STUDY_SECTION_NAME: Oncology B[ONCB]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE There is a well documented need to involve greater numbers of veterinarians in biomedical research. By virtue of their broad training, veterinarians possess a unique skill set that makes them well suited to productively engage in interdisciplinary biomedical research. The Cornell University Veterinary Investigator Program (VIP) is designed to provide rigorous, hypothesis-driven laboratory research experiences to early stage DVM students. By exposing veterinary students to the importance, impact, and appeal of basic and translational science, this Program will have long-term impacts on the next generation of veterinarians, with significant implications for biomedical research and public health.

PI_NAMEs: WEISS, ROBERT S (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Academia;Admission activity;Area;Biology;Biomedical Research;career;Career Choice;clinical practice;college;Communication;comparative;Dedications;Developmental Biology;Education;Educational workshop;Ethics;experience;Exposure to;Faculty;Funding;Genome;improved;Infection;interest;Laboratories;laboratory experience;Laboratory Research;Malignant Neoplasms;men;Mentors;Metabolism;Oral;Participant;Peer Review;posters;preference;Process;Productivity;programs;Public Health;Publications;Regenerative Medicine;Reproducibility;Reproduction;Research;research and development;Research Personnel;Research Technics;Research Training;Resources;responsible research conduct;Science;Scientific Inquiry;skills;stem cells;Students;Techniques;Training;United States National Institutes of Health;Universities;Veterinarians;Veterinary Medicine;Veterinary Schools;Vocational Guidance;Woman;Writing


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_DEPT: PATHOLOGY

PHR: Project Narrative NIAGADS is an important NIA infrastructure for Alzheimer's disease (AD) research. NIAGADS ensures high quality data and resources are available to the research community for AD genetics research.

PI_NAMEs: WANG, LI-SAN  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Affect;Algorithms;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Biological Markers;Clinical Trials;cloud based;Cognitive;cognitive system;cohort;Collaborations;Communities;community research;computerized tools;dashboard;Data;data access;Data Analyses;Data Collection;Data Coordinating Center;data exploration;data integration;data repository;data resource;data sharing;data storage site;data submission;Dementia;Deposition;Diagnostic;Disease;Educational workshop;Ensure;epigenomics;Etiology;exome;exome sequencing;FAIR principles;functional genomics;Funding;gene discovery;General Population;Generations;Genes;Genetic;Genetic Diseases;Genetic Research;genetic resource;genetic risk factor;Genetic study;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;genome-wide;genomic data;Genomics;Genotype;Goals;Gold;Human Genetics;Immunity;informatics infrastructure;Informed Consent;Infrastructure;Ingestion;insight;interoperability;Intervention;Knowledge;knowledgebase;large datasets;Late Onset Alzheimer Disease;Machine Learning;member;Metadata;Mission;National Institute on Aging;Neuroglia;new therapeutic target;novel therapeutic intervention;outreach program;Pathway interactions;petabyte;Phenotype;phenotypic data;Play;Policies;Prevention;Process;Production;programs;Public Health;Qualifying;Reporting;repository;Research;Research Personnel;Resources;Role;Sampling;Security;Services;Single Nucleotide Polymorphism;Site;social media;symposium;System;Technology;tool;transcriptomics;United States National Institutes of Health;Update;Variant;Visualization;web site;whole genome

PROJECT_TITLE: THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Strong genetic evidences suggest that microglia may play a key role in the pathogenesis of Alzheimer’s Disease (AD). DAP12, as an adaptor protein involved in the cross-interaction of signal networks of surface immune receptors in microglia, has been indicated to be a central player in an AD-associated microglia specific module. Our study reveals that DAP12 differentially regulates microglia-dependent tau metabolism and microglia- mediated inflammation, providing us a comprehensive understanding the disease mechanism underlying the fundamental contribution of microglia to the development of AD.

PI_NAMEs: LUO, WENJIE  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: AD transgenic mice;Adaptor Signaling Protein;Affect;age group;Alzheimer's Disease;Binding;Brain;brain cell;cell type;Complement 1q;Complement 4b;complement pathway;Complex;cytokine;Cytometry;Data;Dementia;Development;Disease;Disease associated microglia;Dissociation;early onset;effective therapy;Elderly;Event;extracellular;Genes;Genetic;genetic signature;glial activation;Gliosis;Goals;high resolution imaging;Human;Immune;Immune response;Immunologic Receptors;In Vitro;in vivo;induced pluripotent stem cell;Inflammation;Inflammatory;Inflammatory Response;knock-down;Lentivirus Vector;Macrophage-1 Antigen;MAP Kinase Gene;MAPK8 gene;Mediating;Metabolism;Microglia;Molecular;mouse model;Mus;mutant;Natural Immunity;Neurons;novel therapeutic intervention;overexpression;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Phagocytes;Phagocytosis;Phenocopy;Phosphorylation;Play;Proteins;receptor;Regulation;response;Role;Signal Pathway;Signal Transduction;Signal Transduction Pathway;single nucleus RNA-sequencing;Spatial Distribution;Specificity;Stimulus;Surface;System;tau aggregation;tau Proteins;Tauopathies;Testing;Therapeutic Intervention;transcriptome;transcriptomics;Transgenic Mice;TREM2 gene;TYRO Protein Tyrosine Kinase Binding Protein;uptake

PROJECT_TITLE: Essential roles of DAP12 in tau metabolism and inflammation in Alzheimer's disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: HS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Non-technical skills impact patient safety in surgery, but the gold-standard for assessing team performance primarily relies on the use of subjective assessments that require trained observers. Currently, no automated devices or sensing-based metrics exist for objectively quantifying and monitoring non-technical skills. A sensing- based system incorporating objective metrics will provide a novel assessment and feedback tool for measuring the effectiveness of team training and identifying behaviors that influence surgical team performance, which can ultimately lead to improved patient safety within the operative environment.

PI_NAMEs: STEFANIDIS, DIMITRIOS ;YU, DENNY  (contact)

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Wearable sensors for modeling and assessing nontechnical skills in surgery

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative More than 9 in 10 individuals carrying a penicillin allergy label are not truly allergic, which has widespread consequences that include a higher risk of antibiotic-resistant bacteria. Removal of inaccurate penicillin allergy labels (de-labeling) is a safe and recommended strategy to improve antibiotic prescribing. This project seeks to measure, understand, and improve equitable access to penicillin allergy de-labeling.

PI_NAMEs: BLUMENTHAL, KIMBERLY GOLD (contact);WURCEL, ALYSSE GAIL

PROGRAM_OFFICER_NAME: LIN, LEYI

PROJECT_TITLE: Improving Equitable Access to Penicillin Allergy De-Labeling


ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE The present study has the potential to impact public health by improving the quality of mental health services received by children in schools. The research activities will improve our understanding of the complex problems that may occur when mental health services are collocated in schools and examine possible solutions. Intervention and implementation strategies to support this type of work will be important going forward given that s c hool dis tric ts are inc reas ingly relying on c ontrac ted m ental health providers and c olloc ation is a c om m on m odel in other settings (e.g., primary care).

PI_NAMEs: WOLK, COURTNEY LYNN BENJAMIN (contact)

PROGRAM_OFFICER_NAME: HAUGSTETTER, MONIKA

PROJECT_TITLE: Adapting and implementing TeamSTEPPS in school mental health


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative  Impairments in cognitive performance of tasks known to require the intact functioning of the prefrontal cortex, such as impairments in cognitive flexibility, are associated with multiple psychiatric disorders that impart substantial public health burdens, including major depression and schizophrenia. Stress, in addition to impairing cognitive flexibility directly, is associated with an increased risk of major depression and schizophrenia and therefore may provide either a pathogenic or mediating link between the pathophysiological manifestation of these disorders and their associated cognitive deficits. A circuit-level understanding of the role of prefrontal neuronal subpopulations is therefore critical in identifying potential targets for pharmacotherapeutic or neuromodulatory interventions.

PI_NAMEs: SPELLMAN, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Anatomy;Animal Model;anxiety symptoms;Attention;Award;Behavior;Behavioral;behavioral response;Calcium;Calcium Signaling;Characteristics;Chronic;Chronic stress;Code;Cognitive;Cognitive deficits;cognitive performance;Connecticut;Cues;density;depressive symptoms;Disease;Environment;experimental study;flexibility;Fluorescence;follow-up;Genetic;glutamatergic signaling;Glutamates;Goals;Human;Image;Imaging Techniques;Impaired cognition;Impairment;in vivo imaging;information processing;Institution;Intervention;Investigation;Laser Scanning Microscopy;Light;Link;Major Depressive Disorder;Mediating;medical schools;member;Mental Depression;Mental disorders;Mentors;Microscopy;Modeling;Mus;Nature;neural circuit;Neurodegenerative Disorders;Neurons;neuroregulation;Output;Pathogenicity;Pathway interactions;Patients;Pharmacogenetics;Phase;Population;Prefrontal Cortex;Presynaptic Terminals;Probability;Property;Protocols documentation;Public Health;Publishing;rapid detection;Regulation;Research;response;Risk;Rodent;Role;Sampling;Scanning;Schizophrenia;Secure;Signal Transduction;social defeat;Specific qualifier value;Speed;Stimulus;Stress;Surveys;Synapses;targeted treatment;Task Performances;temporal measurement;tenure track;Testing;Therapeutic Intervention;Time;two-photon;Universities;Vertebral column;Work

PROJECT_TITLE: Prefontal Microcircuits Underlying Cognitive Flexibility

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE In the absence of clinical trial data, causal inference from observational multidrug-resistant tuberculosis (MDR- TB) cohort data is needed in order to generate robust evidence to guide treatment and care. A lack of high quality, systematically collected data and a limited armamentarium of statistical methods applied and/or tailored to MDR-TB cohorts constitutes a major barrier to guaranteeing optimal treatment for MDR-TB patients throughout the United States and the world. Our group is uniquely positioned to conduct novel analyses on high quality data, in order generate robust evidence to answer urgent research questions prioritized by the World Health Organization, with the overall goal of informing optimal care and treatment for patients with MDR-TB globally.

PI_NAMEs: FRANKE, MOLLY FORREST (contact)

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Address;Adverse event;adverse event monitoring;Aminoglycosides;analytical method;authority;Caring;Cessation of life;Clinical Trials;cohort;Cohort Analysis;cost;Country;Data;Data Set;Data Sources;disease transmission;Drug usage;Effectiveness;Epidemiologic Methods;Extreme drug resistant tuberculosis;Fluoroquinolones;Goals;Guidelines;Health system;improved;Injectable;Injections;isoniazid;Life;Methods;Monitor;Morbidity - disease rate;Multi-Drug Resistance;Multidrug-Resistant Tuberculosis;National Institute of Allergy and Infectious Disease;novel;off-label use;optimal treatments;Patients;Pattern;permanent hearing loss;Persons;Pharmaceutical Preparations;polypeptide;Positioning Attribute;prevent;programs;prospective;Recommendation;Regimen;Research;Resistance;Resources;Rifampicin resistance;Safety;side effect;Source;Standardization;Statistical Methods;Strategic Planning;treatment duration;Treatment Protocols;Tuberculosis;tuberculosis drugs;tuberculosis treatment;United States;World Health Organization

PROJECT_TITLE: Strengthening evidence on optimal multidrug-resistant tuberculosis treatment regimens through improved epidemiologic methods

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Immunotherapy;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Oral cavity cancer outcomes have not significantly improved over the past 30 years. Immunotherapy is a new type of cancer treatment that uses the body’s own immune cells, such as T cells, to attack cancer, but it only works in a small number of patients for reasons that we do not understand. In this proposal, we aim to improve oral cavity cancer outcomes by determining why T cells do not kill cancer cells and discovering new ways to increase the ability of T cells to attack cancer.

PI_NAMEs: MULLINS, RILEY DALTON ZALE (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: 3-Dimensional;Advisory Committees;anti-PD-1;Antibodies;Antigens;Antitumor Response;Binding Sites;cancer cell;Cancer cell line;Cancer Control;Cancer Etiology;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;Cell Death;Cell Line;Cell Separation;cell type;Cells;checkpoint inhibition;Chimeric Proteins;ChIP-seq;Chronic;Clinical;Coculture Techniques;Collagen;CRISPR interference;cytokine;cytotoxicity;Data;Data Set;Development;DNA;DNA Binding;Electroporation;Epithelium;Exclusion;exhaust;exhaustion;experimental study;Fellowship;Flow Cytometry;Functional disorder;functional restoration;Gene Expression;Gene Targeting;Genes;Genetic Transcription;Goals;Head and Neck Cancer;hybrid protein;Hybrids;Immune;immune checkpoint;immunocytochemistry;Immunology;Immunotherapy;improved;In Vitro;Infiltration;Inflammatory;insight;knock-down;Knowledge;Libraries;Literature;malignant mouth neoplasm;Malignant Neoplasms;Maps;Measures;Membrane;Mentorship;Mesenchymal;Methods;Modeling;Morbidity - disease rate;mortality;mouth squamous cell carcinoma;new therapeutic target;novel;Organoids;Outcome;Paracrine Communication;Patients;Peripheral;Phenotype;Physicians;progenitor;prognostic;Proliferating;protein expression;Protein Secretion;Proteins;Receptor Activation;Recurrence;Research;Resistance;response;RNA;Role;Sampling;Scientist;Signal Transduction;single-cell RNA sequencing;Smoking;stem;Survival Rate;System;T cell infiltration;T cell response;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;therapeutic target;Thymocyte Selection;Tissue-Specific Gene Expression;Training;transcription factor;transcriptome sequencing;Transposase;treatment strategy;tumor;Tumor-Derived;vector control;Work

PROJECT_TITLE: The Determinants of CD8 T cell Dysfunction in Oral Cavity Squamous Cell Carcinoma

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Skin Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Melanocytes produce the melanin pigments that provide organismal protection against ultraviolet irradiation, which can cause DNA damage. Understanding melanocyte biology is relevant to public health since loss of melanocytes can result in the depigmentation disease vitiligo, and unrestrained expansion of melanocytes can result in melanoma, the deadliest form of skin cancer. This proposal aims to determine the mechanisms through which melanocyte stem cell behavior is altered by ultraviolet irradiation, in order to ultimately manipulate this population in human patients for the improved treatment of vitiligo, and the prevention of melanoma.

PI_NAMEs: WHITE, ANDREW C (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Antibodies;Architecture;Biological Models;Biology;cell behavior;cell motility;Cell Separation;cell type;Cells;Chromatin Remodeling Factor;Cutaneous;Cytokine Signaling;Data;Dependence;Development;Disease;DNA Damage;Epidermis;Event;experience;genetic manipulation;Genetic Transcription;Goals;Hair follicle structure;Health;Human;Immunology;Impairment;improved;in vivo;Inflammation;Inflammatory;innovation;irradiation;Knowledge;Lesion;loss of function;Macrophage;Mediating;Mediator;Melanins;melanocyte;Melanoma;Melanoma Tumor;Methods;Microbiology;migration;Mission;Mole the mammal;Molecular;Motility;mutant;Mutation;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;neutrophil;Neutrophil Infiltration;novel strategies;novel therapeutic intervention;novel therapeutics;overexpression;Patients;Pattern;Pigmentation physiologic function;Pigments;Population;Prevention;Process;Property;Public Health;Radiation exposure;Radiation therapy;recruit;Reporting;response;Signal Pathway;Signal Transduction;Skin;Skin Cancer;skin disorder;small molecule;Source;stem cell biology;stem cell migration;stem cell population;stem cell proliferation;stem cells;Testing;Tissues;TNF gene;Transcriptional Regulation;transcriptomic profiling;transcriptomics;tumor;tumor initiation;tumorigenic;Ultraviolet B Radiation;ultraviolet irradiation;UVB induced;Vitiligo;Work

PROJECT_TITLE: Regulators of Melanocyte Stem Cell Migration and Melanoma Initiation in Response to Cutaneous UVB Irradiation

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Infectious Diseases;Urologic Diseases

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Urease-positive organisms cause detrimental consequences among long-term catheterized individuals, including painful catheter encrustation, blockages, stone formation, all of which increase morbidity and mortality. This project aims to determine the mechanism of action of novel compounds that decrease bacterial urease activity and to conduct pre-clinical assessment of their therapeutic potential. This project will provide new insight into urease enzyme regulatory mechanisms and provide new targets for therapeutics that prevent catheter-associated urinary tract infection associated morbidity and mortality, without the use of antimicrobials.

PI_NAMEs: GUTERMAN, LAUREN BERYL (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acids;Active Sites;Ammonia;Animals;Antibiotics;antimicrobial;Bacteremia;Bacteria;Bathing;Biological Availability;Biomass;Bladder;Carbon Dioxide;catheter associated UTI;Catheterization;Catheters;Cells;Cessation of life;Clinical;Clinical Trials;Communicable Diseases;Cytoplasm;Data;Development;Dose;Drainage procedure;drug discovery;efficacy evaluation;efficacy testing;enhancing factor;Enterococcus faecalis;Enzymes;experimental study;Extracellular Space;Foundations;Future;Glass;Goals;Histamine;Hospitalization;Human;Imidazole;improved;In Vitro;in vitro activity;in vitro Model;Incidence;Incubated;Individual;Indwelling Catheter;Infection;inhibitor;Innate Immune Response;insight;instrumentation;interest;Internal Medicine;Investigation;Ions;Klebsiella aerogenes;Knowledge;Laboratories;Length of Stay;Leu-Gly;Measures;medical schools;Mentors;Messenger RNA;metabolomics;metalloenzyme;microbial;Microbial Biofilms;Mirabilis;Modeling;Morbidity - disease rate;Morganella morganii;mortality;mouse model;National Research Service Awards;new therapeutic target;Nickel;novel;novel therapeutics;Organism;Pain;pathogen;Pathogenesis;Patient-Focused Outcomes;Patients;phenylpyruvate;Physicians;Physiological;pre-clinical assessment;Preceptorship;Precipitation;prevent;Process;Production;Proteins;Proteus mirabilis;Providencia;Publications;Research;Risk;Science;Scientist;Sepsis;Severities;Severity of illness;side effect;Staphylococcus aureus;System;Temperature;Testing;Therapeutic;Time;Tissues;Toxic effect;Training;translational potential;United States Food and Drug Administration;Urea;Urease;urinary;Urinary Calculi;Urinary Catheterization;Urinary tract;Urinary tract infection;Urine;Virulence Factors;Water;Work

PROJECT_TITLE: Harnessing polymicrobial interactions in the catheterized urinary tract to identify novel inhibitors of Proteus mirabilis urease activity


ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: The current proposal is to study how TREM2 protein interacts with other proteins in the brain's immune cell, called microglia. Certain genetic variations in the TREM2 is known to increase the risk of developing Alzheimer's disease (AD). The successful completion of the proposed work will therefore help us understand the relationship between TREM2 and the AD risk.

PI_NAMEs: KIM, TAE-WAN  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;amyloid pathology;Animal Model;ascorbate;Biological;Biological Process;Biology;Brain;Cell Line;Cells;Code;commune;Complex;Disease;Enzymes;Etiology;Genetic Variation;Human;human induced pluripotent stem cells;Immune;knock-down;Knowledge;Label;Ligands;Mass Spectrum Analysis;Mediating;Methods;Microglia;Molecular;novel;Pattern;Peroxidases;Play;protein complex;protein protein interaction;Protein-Protein Interaction Map;Proteins;Proteomics;receptor;Regulation;Research;Research Priority;response;Risk;risk variant;Role;Signal Transduction;Techniques;Testing;three-dimensional modeling;TREM2 gene;Variant;Work

PROJECT_TITLE: Microglial TREM2 Interactome in Alzheimers Disease


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative The proposed collaborative research intervention will investigate the feasibility, acceptability, and associated benefits and harms of integrating fentanyl test strip education and distribution into existing opioid overdose education and naloxone distribution programs in rural and urban communities. Fentanyl test strip education and distribution is an emerging harm reduction strategy that is becoming an increasingly common practice in some parts of the United States, but research supporting the intervention is limited. We expect that the findings of this study will advance the existing scientific knowledge related to fentanyl test strip education and distribution and inform decisions by public health leaders and policy makers on whether to support the continuation and expansion of fentanyl test strip education and distribution in Ohio and nationally.

PI_NAMEs: MICHAELS, NICHOLE L (contact);SMITH, GARY A.

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: acceptability and feasibility;Adoption;Age;analog;arm;base;Behavior;Cause of Death;Cluster randomized trial;Cocaine;Communities;community organizations;comparison intervention;Consumption;County;Data;Death Rate;design;Drug Addiction;Drug Prevention Program;drug testing;Drug user;Education;Emergency Care;Ensure;experience;Face;Fatality rate;Fentanyl;fentanyl analog;fentanyl test;fentanyl use;Goals;Harm Reduction;Health;health disparity;Heroin;high risk population;Home;Illicit Drugs;improved;Individual;Ingestion;Intervention;intervention program;Knowledge;manufacture;Materials Testing;Methadone;Morbidity - disease rate;mortality;naloxone dispensing;naloxone dosing;Nature;off-label use;Ohio;Opioid;Opioid Analgesics;opioid epidemic;opioid mortality;opioid overdose;Outcome;Overdose;overdose death;overdose education;Overdose reduction;overdose risk;Pharmaceutical Preparations;pill;Policy Maker;Population;prevent;programs;Public Health;Publishing Peer Reviews;Research;Research Support;Risk;Risk Reduction Behavior;Rural;Rural Community;Rural Population;Sampling;Self Efficacy;Site;synthetic opioid;Test Result;test strip;Testing;Time;Tramadol;trial design;United States;Urban Community;Urban Population;Urine

PROJECT_TITLE: Evaluating the impact of fentanyl test strip use among rural and urban populations

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ORG_CITY: VERMILLION

ORG_NAME: UNIVERSITY OF SOUTH DAKOTA

ORG_STATE: SD

PHR: PROJECT NARRATIVE The Graduate Research Training Initiative for Student Enhancement at the University of South Dakota (G- RISE USD) will develop a biomedical doctoral training program that produces a highly qualified, diverse pool of biomedical scientists and prepares them for a variety of potential career paths. The program will seek to train students from diverse populations that reflect South Dakota and the surrounding region, emphasizing American Indians, Latinos, 1st generation college students, economically disadvantaged students, and students from rural backgrounds. These trainees will be prepared for careers in the public and private sector through professional development workshops and access to graduate level classes in the fields of business, law, communication, and education.

PI_NAMEs: BAUGH, LEE ;BURRELL, BRIAN DONALD (contact);LEE, LANCE ;MCFADDEN, LISA M;PIETRI, JOSE ENRIQUE

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: South Dakota;Universities

PROJECT_TITLE: G-RISE University of South Dakota

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Hearing Loss;Neurosciences;Rehabilitation

ORG_NAME: NEW YORK UNIVERSITY

PHR: The proposed research is relevant to public health because vestibular disorders and hearing loss can triple one’s fall risk and have a profound effect on one’s independence and participation in activities of daily living. This project is relevant to the mission of the NIDCD because it is uncovering new knowledge to better the overall health of these individuals. By understanding the relationship between neurobiological differences and balance performance, we can be better positioned to improve balance and function in over 1/3 of adults in the United States who seek medical attention for vestibular disorders or hearing loss.

PI_NAMEs: MORRIS, BRITTANI A (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Activities of Daily Living;Adult;Affect;Age;analysis pipeline;Anatomy;Attention;Auditory;Auditory system;balance testing;Behavior;Behavior assessment;behavior measurement;Behavioral;Brain;Clinical;Cognitive;Compensation;Complex;Conscious;Cues;Data;Data Set;Dependence;Development;Dizziness;Dorsal;Environment;equilibration disorder;Equilibrium;Evaluation;Exhibits;Eye;fall risk;falls;follow-up;Functional Magnetic Resonance Imaging;Future;Gait;Goals;Health;hearing impairment;improved;indexing;Individual;inner ear diseases;Intervention;Knowledge;Literature;Measures;medical attention;Mission;Motor;motor control;Movement;National Institute on Deafness and Other Communication Disorders;Network-based;neural;neural patterning;Neurobiology;neuroimaging;normal hearing;Participant;Pathway Analysis;Patients;Performance;Peripheral;Persons;Positioning Attribute;Postdoctoral Fellow;Posture;Public Health;Research;Resources;Rest;Sensorineural Hearing Loss;Sensory;sensory input;Testing;United States;Vestibular Diseases;Vestibular loss;vestibular system;virtual reality environment;Vision;Visual;Visual attention;visual stimulus;Work

PROJECT_TITLE: Neural and Behavioral Indices of Balance Performance in Individuals with sensory loss


ORG_CITY: Aurora

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The current proposal is a new postdoctoral training program in the Department of Anesthesiology at the University of Colorado School of Medicine. There is a critical need in biomedical research to enhance the training and retention of clinician-scientists, particularly in the field of Anesthesiology. The broad objective of this training program is to provide training to MD postdoctoral fellows in clinical and basic science related to anesthesiology and perioperative medicine.

PI_NAMEs: JEVTOVIC-TODOROVIC, VESNA  (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TITLE: Anesthesiology Mentored Research Training


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CHICAGO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative RNA modifications (collectively known as the epitranscriptome) play critical roles in both transcriptional and post-transcriptional gene expression regulation and broadly impact mammalian development and human diseases. The proposed research will develop high-throughput, high-resolution, and high-sensitivity methods to simultaneously map multiple RNA modifications for functional investigations of the epitranscriptome.

PI_NAMEs: HE, CHUAN  (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TERMS: Adenosine;Affect;Animal Model;Area;base;Basic Science;Binding Sites;bioinformatics tool;Biological;Biological Process;Biology;Cell Differentiation process;chemical group;Chemicals;Chemistry;Chromatin;Chromosomes;Clinical;Communities;Complex;computational pipelines;Databases;Dedications;demethylation;Development;Disease;Engineering;Enhancers;Enzymes;epitranscriptome;epitranscriptomics;Evolution;experimental study;Gene Expression Regulation;Genetic Transcription;Genomics;human disease;Introns;invention;Investigation;Life;Mammals;Maps;Medical;Messenger RNA;method development;Methods;Methylation;Modification;Mutation;nanopore;Neurons;new technology;Nucleic Acids;Physiological;Play;Post-Transcriptional RNA Processing;posttranscriptional;promoter;Property;Proteins;Protocols documentation;Pseudouridine;Reaction;Reader;Regulation;Research;Resolution;Reverse Transcription;Ribosomal RNA;RNA;RNA metabolism;RNA Processing;RNA-Binding Proteins;Role;Sampling;sequencing platform;Site;stem cell differentiation;Study models;System;Testing;Tissues;Transcript;transcriptome;Transfer RNA;Translations;Untranslated RNA;Up-Regulation;Work

PROJECT_TITLE: Center for dynamic RNA epitranscriptomes - Renewal

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The primary goals of the proposed Research Program on Cognition and Neuromodulation Based Interventions (RP-CNBI) are to create a sustainable and robust infrastructure (Goal 1), provide thorough training to the next generation of ADRD researchers (Goal 2), and develop consensus statements and centralized analytic platforms (Goal 3). The combination of these resources will enhance methodologic rigor, training, and access to resources necessary for high-quality non-pharmacologic intervention research, collectively enhancing Milestones 8A-E.

PI_NAMEs: HAMPSTEAD, BENJAMIN MICHAEL (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease related dementia;analog;Area;Clinical;Clinical Trials;clinically relevant;Cognition;Consensus;Data;Dedications;Developing Countries;Development;Environment;Equipment;Evaluation;Faculty;Funding;Geography;Goals;Health;Healthcare Systems;indexing;Infrastructure;interest;International;Internet;Intervention;Intervention Studies;Knowledge;Learning;meetings;Mentors;Mentorship;Meta-Analysis;Methodology;Michigan;neuroimaging;neuroregulation;next generation;Nonpharmacologic Therapy;older adult;Outcome;Outcome Measure;pharmacologic;Positioning Attribute;post-COVID-19;Postdoctoral Fellow;Program Accessibility;programs;repository;Research;Research Personnel;Resources;Role;success;Training;Translations;Travel;treatment and outcome;Treatment outcome;treatment planning;treatment trial;Underserved Population;Universities;virtual;Wages


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Relevance Little is known about how amyloid-beta and tau interact to disrupt neural systems function in the intact brain across behavioral states. By integrating and applying a diverse set of tools, including concomitant mini-microscope imaging of dynamic calcium activity and local field potential recording in freely behaving mouse models of early onset Alzheimer’s disease and late onset Alzheimer’s disease, together with a viral vector that enables calcium imaging in tau-laden brain cells, we will address this knowledge gap. These efforts will advance Alzheimer’s disease modeling, set the stage for further research both mechanistic and translational, and inform therapeutic development.

PI_NAMEs: GOMPERTS, STEPHEN N. (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Address;adeno-associated viral vector;Affect;Age;Alzheimer's Disease;Alzheimer's disease model;Amyloid;Amyloid Beta A4 Precursor Protein;Amyloid beta-42;Amyloid beta-Protein;Anesthesia procedures;Animals;apolipoprotein E-4;awake;Behavioral;Body Temperature;Brain;brain cell;Breeding;Calcium;Cells;Consumption;Dependence;Development;Early Onset Alzheimer Disease;Electrodes;Evaluation;Exploratory Behavior;Failure;Frontotemporal Dementia;Functional disorder;Generations;Genetic;genetic risk factor;Goals;Hippocampus;Homeostasis;Human;Image;Image Analysis;image registration;Imaging technology;Impairment;Implant;indexing;insight;Knock-in;Knowledge;Late Onset Alzheimer Disease;Learning;lens;Medial;Microscope;microscopic imaging;Modeling;Monitor;mouse model;Multimodal Imaging;multiphoton imaging;Mus;mutant;Nerve Degeneration;neural;neural circuit;Neurofibrillary Tangles;Neuronal Dysfunction;Neurons;neurophysiology;new technology;novel;novel therapeutics;old mice;overexpression;Pathology;Physiological;Physiology;programs;Research;Risk;risk variant;Running;Sampling;serial imaging;Series;sex;Sleep;System;tau aggregation;tau interaction;tau Proteins;Technology;technology/technique;therapeutic development;Time;tool;TREM2 gene;two-photon;unpublished works;Viral Vector

PROJECT_TITLE: Neural Circuit Disruption in Freely-Behaving models of Alzheimer's Disease.

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND-R]


ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE Severe asthma (SA) is complex, multifactorial and refractory to treatment by corticosteroids (CS). In recent years, some progress has been made in its treatment with the advent of biologics. Using state-of-the-art immunological and molecular multi-omics approaches the projects and cores working synergistically will establish new concepts in immune-epithelial interactions underlying asthma pathogenesis. It is anticipated that the effector pathways identified in SA in this study can be ultimately targeted to limit disease morbidity.

PI_NAMEs: RAY, ANURADHA  (contact);WENZEL, SALLY E

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Adrenal Cortex Hormones;Air;airway epithelium;Animal Model;Anti-Inflammatory Agents;Apoptosis;Asthma;asthmatic;asthmatic patient;Bioinformatics;Biological;Biological Markers;Biological Products;bronchial epithelium;Bronchoalveolar Lavage;CD8-Positive T-Lymphocytes;Cell Culture System;Cell Death;Cell Separation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Characteristics;Chemotactic Factors;clinical diagnosis;Collecting Cell;Communication;Complex;Computer Analysis;cost;CXCL10 gene;Cytometry;Data;Development;Disease;disease model;disorder control;Epigenetic Process;Epithelial Cells;Epithelium;experience;Failure;Functional disorder;Gene Expression Profiling;Genetic;Glucocorticoid Receptor;Guidelines;Heterogeneity;Human;IL18 gene;Immune;Immune response;Immune System Diseases;Immunologics;Immunosuppression;In Vitro;Inflammation;Inflammatory;Inhalation;Innate Immune Response;interest;Interferon Type II;Interferons;Interleukin-4;Knowledge;Laboratories;Liquid substance;Lymphocyte;Memory;Molecular;molecular phenotype;Molecular Target;Morbidity - disease rate;mouse model;Mucins;multiple omics;Natural Immunity;new therapeutic target;novel;novel therapeutics;Pathogenesis;Pathway interactions;Patients;Peptide Hydrolases;Phenotype;Process;Production;programs;Publishing;pulmonary function;Quality of life;Refractory;Regulation;repaired;Research;response;Risk;Role;Sampling;side effect;Signal Transduction;STAT1 gene;Statistical Data Interpretation;Steroid Resistance;Steroids;Stimulus;Subgroup;Symptoms;T cell receptor repertoire sequencing;T-Lymphocyte;targeted treatment;Techniques;Time;Tissues;trait;transcriptome sequencing;treatment response

PROJECT_TITLE: Immune Airway-Epithelial Interactions in Steroid-Refractory Severe Asthma


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Patient Safety;Radiation Oncology

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Narrative We will develop a dosimetry-guided treatment planning platform that will provide clinicians with a new capability to effectively and conveniently plan, on an individualized basis, what activity to administer to a patient undergoing targeted radionuclide therapy. This study is relevant to public health because a dosimetry-guided personalized approach to treatment is likely to substantially improve patient outcomes compared to current standard practice of administering a fixed activity to all patients.

PI_NAMEs: DEWARAJA, YUNI K (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: absorption;Clinic;Clinical;clinical practice;Clinical Protocols;clinical translation;Code;Collaborations;Computer software;cytotoxic radiation;data handling;design;Development;Discipline of Nuclear Medicine;Dose;dosimetry;Ensure;Environment;experience;FOLH1 gene;Foundations;Future;Image;Image Analysis;imaging biomarker;Imaging Device;imaging Segmentation;improved;individualized medicine;industry partner;innovation;Kidney;Label;Learning;Lesion;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Imaging;Methods;Modeling;Neuroendocrine Tumors;novel;Organ;Outcome;Patient-Focused Outcomes;Patients;Peptide Receptor;personalized approach;predictive modeling;Procedures;prospective;Protocols documentation;Public Health;Radiation therapy;Radioisotopes;Radiolabeled;radioligand;radiomics;Radionuclide therapy;reconstruction;Recording of previous events;Reproducibility;response;Risk;single photon emission computed tomography;Software Validation;standard of care;Standardization;Survival Rate;System;targeted agent;Test Result;Testing;theranostics;Therapeutic Effect;Therapy Clinical Trials;Time;tool;Toxic effect;Translating;treatment planning;tumor;Weight;X-Ray Computed Tomography

PROJECT_TITLE: Bringing Capacity for Theranostic Dosimetry Planning to the Nuclear Medicine Clinic


NIH_SPENDING_CATS: Asthma;Clinical Research;Lung

PHR: The Administrative Core will provide oversight on all activities in Projects and scientific cores that will collectively study interactions between immune and epithelial cells to study disease heterogeneity in severe asthma.

PI_NAMEs: RAY, ANURADHA  (contact)

PROJECT_TITLE: Core A


PHR: NARRATIVE Severe asthma, which is generally refractory to standard therapy, has a disproportionate impact on disease morbidity, mortality, health care spending, and overall economic outcome. Elucidation of immune pathways, which could be amenable to novel therapeutic strategies aimed at mitigating such impact is warranted.

PI_NAMEs: ORISS, TIMOTHY B (contact)

PROJECT_TERMS: Aftercare;airway epithelium;analytical tool;Antibodies;Asthma;asthmatic;Biocompatible Materials;Biological;Biometry;Biopsy;Blood Cells;Bronchoscopy;Brush Cell;Categories;CD3 Antigens;Cell Culture Techniques;Cell Separation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;Core Facility;cytokine;Cytometry;Data;data acquisition;Data Analyses;data repository;design;Disease;DNA;economic outcome;Eligibility Determination;Ensure;Epithelial Cells;Evolution;Exhalation;Exhibits;firewall;Flow Cytometry;Fluorescence;Freezing;Funding;Healthcare;high dimensionality;Human;human biological material;Human Resources;Immune;Immunologics;Immunophenotyping;Individual;instrument;Interleukin-10;Interleukin-13;Interleukin-4;Interleukin-5;Label;Laboratories;longitudinal analysis;Measures;Memory;Morbidity - disease rate;mortality;multidimensional data;Mus;novel therapeutic intervention;Participant;Pathway interactions;Patients;Performance;Preparation;Procedures;Process;Productivity;programs;Protocols documentation;PTPRC gene;pulmonary function;Questionnaires;Recovery;recruit;Refractory;Research Personnel;Resource Sharing;Resources;RNA;Sampling;Services;Stains;Steroids;Subjects Selections;T cell receptor repertoire sequencing;T-Lymphocyte;Technical Expertise;Techniques;Tissues;transcriptome sequencing;Work

PROJECT_TITLE: Core B


NIH_SPENDING_CATS: Asthma;Bioengineering;Biotechnology;Clinical Research;Data Science;Genetics;Human Genome;Lung;Networking and Information Technology R&D (NITRD)

PHR: Narrative Single-cell multi-omics study provides an unprecedented opportunity to understand immune and molecular basis of severe asthma. We will develop bioinformatic and computational tools to analyze and integrate different types of single-cell data. Our methods and unique multi-omics data will be immediately useful for current and future asthma projects in a wide range of research community in pulmonary medicine.

PI_NAMEs: CHEN, WEI  (contact)

PROJECT_TERMS: airway epithelium;Algorithms;Asthma;asthmatic patient;Bioinformatics;bioinformatics pipeline;bioinformatics tool;Biological;Biology;Biomedical Research;bronchial epithelium;Bronchoalveolar Lavage;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;clinical phenotype;Collaborations;Communication;Communities;computerized data processing;computerized tools;Computing Methodologies;Coupled;Cytometry;Data;data quality;Data Set;design;Diagnosis;DNA Sequencing Facility;Ensure;Epithelial Cells;experience;experimental study;Foundations;Future;Gene Expression;Genes;genomic data;genomic tools;Goals;Grant;Heterogeneity;Immune;Immunologics;Immunology;Immunophenotyping;Information Dissemination;insight;Knowledge;Lung Diseases;Measures;Methods;Molecular;Molecular Profiling;multidisciplinary;multimodal data;Multiomic Data;multiple omics;novel;Pathogenesis;Pathway interactions;Patients;phenotypic data;Pilot Projects;prevent;Process;Proteins;Publications;Pulmonology;recruit;Refractory;Research;Research Personnel;Resolution;sample collection;Services;single cell analysis;single cell genomics;single cell sequencing;single cell technology;single-cell RNA sequencing;Steroids;System;T cell receptor repertoire sequencing;Technical Expertise;Technology;Testing;Tissues;transcriptome sequencing;transcriptomic profiling;Work

PROJECT_TITLE: Core C


PHR: NARRATIVE Severe asthma is a heterogeneous and complex disease with limited options for therapy that involves bidirectional interactions between immune cells in the airways and airway epithelial cells. Project 1 will study at single cell resolution cell types and their molecular networks in asthmatic airways to understand the underlying immune dysfunction in severe asthma. Mouse models of severe asthma will be used in parallel to study mechanisms. The results of the proposed work will identify novel mechanisms of disease pathogenesis and new opportunities for therapeutic development.

PROJECT_TERMS: adaptive immune response;Address;Adrenal Cortex Hormones;Aftercare;airway epithelium;airway hyperresponsiveness;airway inflammation;Algorithms;Aspergillus;Asthma;asthmatic airway;asthmatic patient;Bioinformatics;Biological;Biological Markers;Biological Products;Bronchoalveolar Lavage;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Aging;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chemotactic Factors;Clinic;cohort;Complex;CXCL10 gene;cytokine;Cytometry;Data;Dinucleoside Phosphates;Disease;disease phenotype;Enrollment;Epithelial Cells;Epithelium;Event;Experimental Models;Flow Cytometry;Funding;Gene Expression;Gene Expression Profile;Genes;Glucocorticoid Receptor;Goals;Grant;Hematopoiesis;Heterogeneity;high dimensionality;Human;IL7 gene;Immune;Immune response;Immune System Diseases;Immunologics;In Situ;Innate Immune Response;insight;Interferon Type II;Interleukin-10;Interleukin-4;Interleukin-5;Lymphocyte;Memory;Methods;Modeling;Molecular;Molecular Abnormality;mouse model;mucosal site;Mus;novel;Outcome Measure;participant enrollment;Pathogenesis;Pathway interactions;Patient Selection;Patients;Peptide Hydrolases;Periodicity;Phenotype;Population;Production;profiles in patients;programs;Qualifying;Refractory;Regulation;Reporting;Research;Resolution;response;Role;Signal Transduction;STAT1 gene;Steroids;symptomatic improvement;T cell receptor repertoire sequencing;T-Lymphocyte;targeted treatment;therapeutic development;Time;Tissues;transcriptome;transcriptome sequencing;transcriptomics;treatment response;Work

PROJECT_TITLE: Project 1


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Human Genome;Lung;Precision Medicine

PHR: Heterogeneity of severe asthma remains a substantial obstacle to improved therapies. The previous cycle identified two distinct molecular phenotypes of severe asthma. In this project, these phenotypes will be further refined using cutting edge molecular and computational tools. Additional studies will be performed to better understand the mechanisms for their development and identify novel therapeutic targets.

PI_NAMEs: WENZEL, SALLY E (contact)

PROJECT_TERMS: 17q12;17q21;adaptive immunity;Adverse event;airway epithelium;Animal Model;Apoptotic;Asthma;asthmatic;Bioinformatics;Biological Markers;bronchial epithelium;CCL26 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death;Cell Physiology;Cell Survival;cell type;Cells;Cessation of life;Clinical;clinical phenotype;Coculture Techniques;cohort;computerized tools;Data;Development;Elements;Epigenetic Process;Epithelial Cell Proliferation;Epithelial Cells;Epithelium;ERBB2 gene;Functional disorder;Gene Cluster;Gene Expression;Genes;Genetic;genome wide association study;genomic locus;Growth;Growth Factor Receptors;Heart;Heterogeneity;IL18 gene;Immune;immune activation;Immune response;Immunity;improved;In Vitro;in vivo;in vivo Model;Inflammasome;Inflammatory;Interferons;Interleukin-12;Ligands;Link;Lymphocyte;Methylation;Mitosis;Molecular;molecular phenotype;MUC5AC gene;Mucin 1 protein;Mucins;Natural Immunity;Neurons;new therapeutic target;NF-kappa B;novel;Outcome;Pathway interactions;Patients;periostin;peripheral blood;Phenotype;Precision therapeutics;Process;programs;Proliferating;Protein Analysis;Proteins;Publishing;Refractory;repaired;Reporting;Research;response;Risk;Role;Severities;sialylation;single-cell RNA sequencing;Steroids;Stimulus;System;T-Lymphocyte;targeted treatment;Techniques;Technology;therapeutic target;Tissues;Toll-Like Receptor Pathway;Toll-like receptors;transcriptome sequencing;treatment response;Up-Regulation;Validation;wound healing

PROJECT_TITLE: Project 2


NIH_SPENDING_CATS: Infectious Diseases;Lung

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: The optimal host response to mucosal infection relies on the critical balance between pathogen killing (immunity) and limiting immunopathology (tolerance) in the host. Host disease tolerance is especially important in infections with macroparasites such as helminths that cause significant tissue damage, therefore investigating these host disease tolerance mechanisms may be applicable to the treatment of tissue injury and inflammation of significant public health impact. This proposal will investigate how the secreted protein RELMa contributes to host disease tolerance to helminths through regulation of alternatively activated macrophage subsets, macrophage-helminth interactions and macrophage-lung stromal cell interactions.

PI_NAMEs: NAIR, MEERA GOH (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: 3-Dimensional;Acute;Address;Adoptive Cell Transfers;Adoptive Transfer;Air;airway epithelium;arginase;Back;Biological Assay;Biology;Blocking Antibodies;Bone Marrow;CD4 Positive T Lymphocytes;Cell Communication;Cell Separation;Cells;Chimera organism;Chimeric Proteins;Coculture Techniques;Communicable Diseases;Complement;Cre lox recombination system;cytokine;Data;design;Disease;eosinophil;Epithelial Cells;Equilibrium;experimental study;Gene Expression;genetic signature;healing;helminth infection;Helminths;Hematopoietic;Heterogeneity;Hookworm Infections;Hookworms;Human;Immune;Immune response;Immunity;immunopathology;Impairment;Infection;Inflammation;Inflammatory;inhibitor;Injury;insight;Integrins;Liquid substance;Lung;lung repair;Macrophage;Measures;Mediating;Mesenchymal Stem Cells;migration;Migration Assay;monocyte;mouse model;Mucous Membrane;Mus;new therapeutic target;Nippostrongylus;novel;Parasites;pathogen;pathogenic microbe;Pathogenicity;Pathologic;Pathology;Pathway interactions;Persons;Protein Secretion;Proteins;Public Health;public health relevance;Pulmonary Inflammation;Reagent;Recovery;Regulation;Reporter;resistin;Resolution;response;Rodent;scaffold;Signal Pathway;Signal Transduction;Signaling Molecule;Soil;Sorting;Stromal Cells;Structure of parenchyma of lung;Technology;Therapeutic;tissue injury;tissue repair;Tissues;transmission process;Visualization;wound healing

PROJECT_TITLE: RELMalpha-expressing macrophages mediate host disease tolerance in mucosal infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: LOS ANGELES

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT RELEVANCE TO PUBLIC HEALTH Only recently has a screening and brief intervention in low-income primary care settings been shown to reduce patients' illicit drug use over 3-months. Good as this finding is, the next challenge is to sustain patients' drug use reductions over 12-months to coincide with routine annual primary care visits for rescreening. We propose adding mHealth tools to enhance and sustain drug use reductions in an effective SBI to reduce drug use and prevent addiction.

PI_NAMEs: GELBERG, LILLIAN  (contact);SWENDEMAN, DALLAS TRAVIS

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: Academy;addiction;Administrator;Adoption;Adult;arm;Back;base;Behavioral;behavioral health;California;Caring;Cellular Phone;Chronic;Clinic;Clinical;Cognitive;comorbidity;comparative cost effectiveness;Consolidated Framework for Implementation Research;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;craving;Critiques;dashboard;Data;demographics;Drug Controls;Drug Monitoring;Drug Recalls;drug testing;Drug usage;Drug user;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness/implementation hybrid;Elements;ethnic minority;Federally Qualified Health Center;Feedback;follow-up;Future;Goals;Health;health service use;hybrid type 1 design;illicit drug use;implementation barriers;implementation evaluation;implementation facilitators;improved;Informal Social Control;Insurance Carriers;Intervention;Intervention Trial;Latino;Legal;Low income;marijuana use;Measures;medical specialties;Medicine;Mental Health;Methods;mHealth;mobile application;Monitor;motivational enhancement therapy;novel;opioid epidemic;opioid overdose;Outcome;Pain;parity;Patient Monitoring;patient oriented;Patient Preferences;patient screening;Patient Self-Report;Patients;Pattern;Pharmaceutical Preparations;physical conditioning;Pilot Projects;Policies;preference;prevent;Prevention education;Prevention strategy;Primary Care;primary care patient;primary care provider;primary care setting;primary care visit;primary health center;primary outcome;Problem Solving;programs;Provider;Psychological reinforcement;Public Health;Qualitative Research;Quality of life;Randomized;Recommendation;Recreation;reduced substance use;Research;response;Rewards;Risk;scale up;screening;screening and brief intervention;secondary outcome;Self Correction;Self Management;Single-Blind Study;smartphone application;Subgroup;substance use;Substance Use Disorder;substance use prevention;Symptoms;Tablet Computer;Techniques;Technology;technology platform;Telephone;telephone coaching;Testing;Text Messaging;theories;three-arm study;timeline;tool;treatment as usual;uptake;Urine;Use Effectiveness;Validation;Voice;Work

PROJECT_TITLE: mHealth to Enhance & Sustain Drug Use Reduction of the QUIT BI in Primary Care

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Most patients with acute myeloid leukemia (AML) eventually die when their disease becomes resistant to conventional or even newer treatments. Some of these newer treatments involve drug combinations that include an inhibitor of BCL2 called venetoclax. We have identified novel venetoclax drug combinations with activity that exceed the combinations currently in clinical use, and our proposed studies will involve detailed examination of these promising drug combinations to better understand the markers and mechanisms of sensitivity and resistance, with the goal of delivering better outcomes to patients with AML.

PI_NAMEs: KURTZ, STEPHEN E;TYNER, JEFFREY WALLACE (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Automobile Driving;Azacitidine;BCL2 gene;biobank;Biological Markers;Biology;biomarker identification;biomarker validation;Blinded;Candidate Disease Gene;Cell Differentiation process;Cell Line;Cells;chemotherapy;Clinic;Clinical;clinical biomarkers;clinical predictors;clinical translation;clinical trial analysis;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Complex;Computer Models;Coupled;CRISPR screen;Data;Data Set;Dendritic Cells;Disease;Dropout;Drug Approval;Drug Combinations;drug sensitivity;Drug Targeting;drug testing;Effectiveness;Elderly Acute Myeloblastic Leukemia;Enzymes;Evaluation;Event;Exhibits;FDA approved;FLT3 gene;functional genomics;Genes;Genetic;Genetic Transcription;genome-wide;Genomic approach;genomic data;genomic platform;Goals;Hematologic Neoplasms;Immunophenotyping;improved;Incentives;inhibitor;innovation;insight;knockout gene;Laboratories;Macrophage;Mediating;Mediator;Modeling;monocyte;Mutate;Mutation;Myelogenous;myeloid leukemia cell;neoplastic cell;novel;novel therapeutics;Outcome;participant enrollment;Pathway interactions;patient population;Patients;Pattern;pharmacologic;Population;pre-clinical;predicting response;programs;Progression-Free Survivals;prospective;Proteomics;Refractory;Relapse;Research Personnel;Resistance;resistance mechanism;response;response biomarker;Sampling;screening;Series;Signal Transduction;Specimen;Survival Rate;synergism;Testing;TP53 gene;transcriptome sequencing;Translating;treatment strategy;tumor;Undifferentiated;Validation;Work

PROJECT_TITLE: Mechanisms of venetoclax combination activity in acute myeloid leukemia

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Diabetes;Genetics;Human Genome

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: PROJECT NARRATIVE Combatting the ever-growing health and economic costs associated with diabetes, it is necessary to obtain full knowledge of beta cell dysfunction occurs in the progression to diabetes. Precise gene expression programs within the beta cell are mediated by islet enriched transcription factors and recruited coregulators, whose dynamic interactions are predicted to be compromised in the pathophysiological conditions associated with diabetes. The studies herein aim to define the importance of the Nucleosome Remodeling and Deacetylase complex on modulating the activity of the Pancreas Duodenum Homeobox-1 transcription factor in physiological and pathophysiological conditions associated with Type 2 diabetes.

PI_NAMEs: SPAETH, JASON M (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Adult;Affect;American;ATAC-seq;ATP phosphohydrolase;Beta Cell;Binding;Biochemical;Biological Assay;Blood Glucose;blood glucose regulation;Calcium;Calcium Signaling;Cell Line;Cell Physiology;CHD4 gene;ChIP-seq;Chromatin;chromatin remodeling;Complex;conditional knockout;Data;Deacetylase;Development;Diabetes Mellitus;diabetes mellitus therapy;diabetes pathogenesis;diabetic patient;diabetogenic;Disease;Duodenum;economic cost;endoplasmic reticulum stress;Excision;Functional disorder;Future;G6PC2 gene;Gene Expression;Gene Expression Profile;gene repression;Genes;Genetic;Genetic Transcription;genome-wide;Glucose;Glucose Intolerance;glucose metabolism;glucose tolerance;Goals;Grant;Health;Health Care Costs;High Fat Diet;Homeobox;Human;human tissue;Hyperglycemia;impaired glucose tolerance;Impairment;improved outcome;In Situ;In Vitro;in vivo;in vivo Model;Individual;Influentials;insight;Insulin;Insulin Resistance;insulin secretion;islet;Islets of Langerhans;knock-down;Knockout Mice;Knowledge;Ligation;Link;Mediating;Metabolic stress;Methods;Mitochondria;mouse model;Mus;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Nucleosomes;Organ Donor;Outcome;Pancreas;Pathogenesis;Pathway interactions;Patients;Peripheral;Physiological;postnatal;Production;programs;Proteins;recruit;Research;response;RNA;Rodent;Rodent Model;Role;Signal Transduction;stressor;Structure of beta Cell of islet;Tamoxifen;Testing;transcription factor;Transcriptional Regulation;transcriptome sequencing

PROJECT_TITLE: The role of Pdx1-recruited Chd4:NuRD complex in controlling mature #-cell function

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Lymphatic Research;Lymphoma;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE African Americans with DLBCL exhibit worse outcomes than Caucasians, even after correcting for potential differences in socioeconomics and access to care. We propose to comprehensively examine the distinct genetics of DLBCL in African Americans. We will also study the mechanisms of genomic alterations that are more frequently found in African American patients.

PI_NAMEs: DAVE, SANDEEP  (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Address;adverse outcome;Affect;African American;African American population;Age;B-Lymphocytes;Bioinformatics;BRAF gene;Caucasians;Cell Lineage;Cells;cohort;Collaborations;Data;Development;Diagnosis;Disease;DNA Sequence Alteration;DNA sequencing;driver mutation;Event;Exhibits;exome sequencing;Foundations;Gene Expression Profile;Gene Silencing;Genes;Genetic;Genetic Heterogeneity;genomic profiling;Genomics;Germ Lines;Goals;Health Services Accessibility;Hematopoietic Neoplasms;histone methyltransferase;improved outcome;in vivo;in vivo Model;Incidence;Inequity;innovation;Institution;Knock-out;Knowledge;KRAS2 gene;large cell Diffuse non-Hodgkin's lymphoma;loss of function;Lymphoma;Lymphomagenesis;Malignant Neoplasms;Methods;Methyltransferase Gene;Molecular;Mutation;Outcome;overexpression;Pathogenesis;Patients;Population;Prognosis;Proliferating;Race;recruit;response;Role;socioeconomics;Structure of germinal center of lymph node;targeted treatment;Therapeutic;Therapeutic Intervention;Time;transcriptome;transcriptome sequencing;tumor;Work

PROJECT_TITLE: Genetic Origins of Adverse Outcomes in African Americans with Lymphoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative  This K01 application describes a research and mentoring strategy for Dr. Su Chin Heo to gain the necessary biological skill set to identify how spatio-temporal genome organization regulates gene expression in meniscus cells. How genome organization of cells within the knee meniscus change with development or degeneration is not well understood, and how biophysical cues impact this process has not been studied. To this end, the proposed work will elucidate changes in the spatio-temporal genome organization in meniscus cells with tissue development or degeneration, and in response to biophysical cues, using both healthy and degenerative cell sources for use as a safe and effective cell therapy for dense connective tissue repair and regeneration.

PI_NAMEs: HEO, SU CHIN  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 3-Dimensional;Acetylation;aggrecan;Animals;Applications Grants;Architecture;Area;Award;Biocompatible Materials;Biological;Biological Assay;Biophysics;Bioreactors;career;Cell Differentiation process;Cell Nucleus;Cell Therapy;Cells;Chromatin;Chromatin Fiber;chromatin remodeling;Collagen;Collagen Type I;Color;Coupled;Cues;Custom;Data;Dense Connective Tissue;Development;Diagnostic;Disease;engineered stem cells;Epigenetic Process;Excision;Extracellular Matrix;Fluorescent in Situ Hybridization;Gene Expression;Genes;Genetic Transcription;Genome;genome-wide analysis;Goals;Health;Histone Acetylation;histone methylation;histone modification;Homeostasis;Human;imaging modality;improved;In Situ Hybridization;Injury;joint loading;Knee;Knee Injuries;Knowledge;mechanical force;mechanical load;mechanical signal;Mechanics;Memory;meniscus injury;Meniscus structure of joint;Mentored Research Scientist Development Award;Mentors;Mesenchymal Stem Cells;microscopic imaging;Microscopy;Modification;nanoscale;Natural regeneration;Nuclear;Nucleosomes;Optics;Organizational Change;Orthopedics;Pattern;Phenotype;Physical environment;Play;pluripotent stem cell differentiation;prenatal exposure;Process;Proteoglycan;reconstruction;Recovery;Regenerative Medicine;Regulation;repair strategy;repaired;Research;Research Personnel;response;RNA;Role;Severities;skills;Source;spatiotemporal;stem cell differentiation;Structure;System;Techniques;Tendon structure;Testing;Therapeutic;Time;tissue regeneration;tissue repair;Tissues;tool;Training;transcriptome sequencing;transmission process;ultra high resolution;Visualization;Work

PROJECT_TITLE: Biophysical regulation of genome architecture in meniscus cells

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Nutrition;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: College Station

ORG_DEPT: NUTRITION

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

PHR: NARRATIVE Elucidate precisely how membrane-targeted dietary bioactives (MTDBs) reshape the cell plasma membrane to suppress aberrant Wnt signaling and tumor formation in the colon. Our novel approach will open up new avenues to reduce the risk of developing colon cancer.

PI_NAMEs: CHAPKIN, ROBERT STEPHEN (contact);KARPAC, JASON S

PROGRAM_OFFICER_NAME: KUMAR, AMIT

PROJECT_TERMS: Abate;Address;antagonist;APC gene;APC mutation;Attenuated;Automobile Driving;beta catenin;Biochemical;Biological Models;biophysical properties;Biophysics;cancer prevention;Cell Line;Cell membrane;Cell Shape;Cell surface;Cells;Cholesterol;Cholesterol Homeostasis;Clustered Regularly Interspaced Short Palindromic Repeats;Colon;Colon Carcinoma;colonic crypt;Colonic Neoplasms;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;Data;Development;dietary;driving force;Drosophila genus;Drug usage;Engineering;Face;Goals;Homeostasis;Human;Implant;in vivo;Intestines;Link;Malignant Neoplasms;Membrane;Membrane Lipids;Membrane Microdomains;Midgut;Modeling;mouse model;Mus;mutant;Mutate;Mutation;nanocluster;neoplastic cell;novel;novel strategies;Oncogenes;Oncogenic;Organoids;overexpression;Phenotype;Plasma Cells;Prevention strategy;Proteolipids;receptor;Receptor Activation;receptor expression;Research;Risk Reduction;Role;self-renewal;Shapes;side effect;Signal Pathway;Signal Transduction;spatiotemporal;stem cells;targeted treatment;Testing;Therapeutic;Tissues;Transgenic Organisms;tumor;Tumor Suppressor Genes;tumorigenesis;WNT Signaling Pathway;Work

PROJECT_TITLE: Targeting plasma membrane spatial dynamics to suppress aberrant Wnt signaling

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Nutrition;Obesity

PHR: Project Narrative We have identified Clstn3 as a key determinant of multilocular lipid droplet morphology and function. We will define the mechanisms of Clstn3 action and its contributions to metabolic physiology. These studies are expected to provide fundamental insight into pathways regulating lipid droplet function and may suggest opportunities for modulating lipid utilization in the setting of metabolic disease.

PI_NAMEs: TONTONOZ, PETER J (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: adipocyte differentiation;Adipocytes;adiponectin;Adipose tissue;Affect;Albumins;Area;Biochemical;Biological;Brown Fat;BSCL2 gene;cell type;Cells;Characteristics;Data;Diabetes Mellitus;diabetes pathogenesis;Ectopic Expression;energy balance;Energy Metabolism;expression vector;Fasting;fatty acid oxidation;gain of function;Genes;Genetic Transcription;Goals;Hepatocyte;Homeostasis;imaging approach;In Vitro;in vivo;induced hypothermia;insight;Insulin Resistance;Laboratories;Link;lipid metabolism;Lipids;Lipolysis;Liver;liver metabolism;loss of function;Mediating;Membrane Proteins;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;Modeling;Molecular;Morphology;Mus;novel;Obesity;Organelles;oxidation;Pathologic;Pathway interactions;Phenotype;Physiological;Physiology;Proteins;Regulatory Pathway;response;Role;Site;Stimulus;Structure;Surface;Testing;Thermogenesis;Tissues;Triglycerides;Ubiquitination;Work

PROJECT_TITLE: Lipid storage and utilization in physiology and obesity


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Lupus;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE Serving as one of four disease teams of the Accelerating Medicines Partnership and Autoimmune Mediated Diseases (AMP-AIM) consortium, the Lupus Omics Cutaneous Kidney Investigative Team (LOCKIT) will enroll and follow an estimated 400 patients with Systemic Lupus Erythematosus (SLE) from nine centers across the country. The initial focus of inquiry will be on the kidney and skin given the high prevalence, severity, and remarkable heterogeneity with which SLE manifests in these organs, and the considerable but poorly understood influences of race, ethnicity, and socioeconomic status on disease phenotypes. With a high priority on identifying early kidney involvement and understanding what drives the range of skin rashes from acute to chronic, state-of the art and next generation analytics will be applied to interrogate tissues, blood, and urine from our informative populations, with the ultimate goal to identify novel targets for intervention.

PI_NAMEs: BUYON, JILL P (contact);PETRI, MICHELLE A;ROVIN, BRAD H;WERTH, VICTORIA P

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Acceleration;Acute;Adaptive Immune System;Address;Autoimmune;Autoimmune Diseases;B-Cell Activation;B-Lymphocytes;Beds;Biological;biological specimen archives;Biology;Biopsy;black women;Blood;California;Cause of Death;cell preparation;Cells;Chronic;Clinical;clinical infrastructure;clinical phenotype;clinically actionable;cohort;Collaborations;Collection;college;Communities;Consent;Country;Cutaneous;Data;data pipeline;Data Set;Databases;Dermatologist;design;digital imaging;Disease;disease classification;disease phenotype;Dissociation;Early identification;Elements;Endothelial Cells;Enrollment;Ethnic Origin;Exanthema;Fibroblasts;flexibility;Genetic;Goals;Heterogeneity;High Prevalence;Hospitals;image archival system;Immune;Immunologics;Informed Consent;Innate Immune System;Institutional Review Boards;Interferon Type I;Intervention;Investigation;Kidney;Kidney Diseases;Lead;Liquid substance;Lupus;lupus cutaneous;Lupus Nephritis;Mediating;medical schools;Medicine;men;Michigan;Molecular;Monitor;monocyte;multi-ethnic;multidisciplinary;next generation;novel;Ohio;Organ;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Pennsylvania;Periodicals;Peripheral;Phase;Phenotype;phenotypic data;Pilot Projects;Population;Prevalence;programs;Proteinuria;Proteomics;Protocols documentation;prototype;Publishing;Race;racial population;recruit;Recurrent disease;Registries;Regulation;Research Personnel;Research Priority;response;Rheumatology;Risk;Salivary Glands;Sampling;San Francisco;scale up;Severities;Site;Skin;skin biopsy;skin disorder;Socioeconomic Status;Specimen;Speed;success;Synovial Membrane;Systemic Lupus Erythematosus;Systems Biology;Technical Expertise;Technology;Texas;Therapeutic;Tissue Preservation;Tissue Procurements;Tissues;transcriptomics;translational applications;treatment response;Tubular formation;Underrepresented Minority;Universities;Urine;Woman;working group;Writing;young woman


ADMINISTERING_IC: AT

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products

ORG_CITY: GREENSBORO

ORG_NAME: UNIVERSITY OF NORTH CAROLINA GREENSBORO

PHR: NARRATIVE The program will train predoctoral students in basic science research related to dietary supplements (botanical natural products) and complementary and integrative medicine. Scientists with training in this area play a critical role in ensuring the safety and efficacy of dietary supplements that are widely used by the general public.

PI_NAMEs: CECH, NADJA B (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: innovative technologies;Integrative Medicine;Natural Products;pre-doctoral;Research;Training

PROJECT_TITLE: Predoctoral Training: Innovative Technologies for Natural Products and Integrative Medicine Research


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: The proposed research is relevant to public health because B cells/antibodies and T cells play vital roles across such a vast range of health conditions, from infection, to autoimmunity, to cancer, that the ability to de- code what they are doing would be an important step forward for diagnosing these conditions. The proposed research is relevant to the NIH's mission of fostering fundamental creative discoveries, innovative research strategies, and their applications as a basis for ultimately protecting and improving health, specifically relating to the diagnosis of human diseases.

PI_NAMEs: ARNAOUT, RAMY  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Affect;Aging;Agreement;Amino Acid Motifs;Amino Acids;Antibodies;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Base Sequence;Big Data;Binding;biophysical properties;Biophysics;Characteristics;Charge;Classification;Clinical;clinical diagnostics;Collection;Complex;Computer Models;computerized tools;Creativeness;Data Set;Dependence;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic tests;Disease;Ensure;Entropy;explainable machine learning;Fostering;Gene Frequency;Genes;Goals;Health;Human;human disease;Immune;immunological diversity;Immunology;improved;Individual;Infection;Influenza vaccination;innovation;Intuition;Learning;Letters;Machine Learning;machine learning method;Malignant Neoplasms;Mathematics;Measurement;Measures;Medicine;Methods;Mission;Modeling;multidisciplinary;multilevel analysis;novel;novel strategies;Outcome;Pattern;Performance;Persons;Physics;Play;Population Heterogeneity;Privatization;Property;Public Health;Reading;Reporting;Research;Role;Sample Size;Sampling;Sampling Errors;Signs and Symptoms;Speed;System;T-Cell Receptor;T-Cell Receptor Genes;T-Lymphocyte;Testing;tool;United States National Institutes of Health;Vaccination;Virus Diseases;Work

PROJECT_TITLE: An Integrated Multilevel Modeling Framework for Repertoire-Based Diagnostics

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]