ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health

ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

PHR: PROJECT NARRATIVE Clinical trials of complementary and integrative health (CIH) interventions, along with their applications, have grown exponentially and there is an urgent need for rigorously conducted systematic reviews and meta-analyses to synthesize evidence to guide stakeholders and inform policy and decision making. We propose the Mindfulness and Integrative Health Data Network (MINDNET) to create a highly usable and accessible data repository, with advanced web interface and R programming for data analysis, as well as pilot awards and asynchronous and synchronous education and training. MINDNET will generate high quality systematic reviews, meta-analyses, and methodology papers from the investigative team and pilot awards to provide clear synthesis of evidence across populations, interventions, conditions, and outcomes (PICOs) for stakeholder use, as well as training and education to foster skills, collaboration, and innovation within the CIH scientific community.

PI_NAMEs: GOLDBERG, SIMON B;LOUCKS, ERIC ;SUN, SHUFANG  (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: Acupuncture Therapy;Address;Advisory Committees;Applications Grants;Area;Award;Categories;chiropracty;Clinical Trials;Code;Collaborations;Communication;Communities;Complementary Health;Data;data access;Data Analyses;data repository;Databases;Decision Making;design;Education;Educational Materials;Eligibility Determination;Energy Therapy;Ensure;evidence base;experience;Feedback;Fostering;Growth;Health;health data;Health Sciences;implementation science;improved;innovation;Insurance Carriers;Integrative Medicine;interdisciplinary collaboration;International;Intervention;Literature;Manuscripts;Medicine;meetings;Meta-Analysis;Methodology;Methods;Mind-Body Intervention;mindfulness;mindfulness intervention;mobile delivery;Modeling;National Center for Complementary and Integrative Health;Natural Products;open data;Outcome;Pain;Paper;Patients;Policies;Policy Maker;Policy Making;Population;Process;Production;programs;Protocols documentation;Provider;psychiatric symptom;psychologic;Psychotherapy;public repository;Qi Gong;quality assurance;R24;repository;Research;Research Personnel;Resource Sharing;Resources;response;Risk;Science;Scientific Advances and Accomplishments;Scientist;Series;skills;social media;Societies;Standardization;Strategic Planning;success;System;systematic review;Tai Ji;Techniques;Text;text searching;tool;Training;Training and Education;Update;usability;user-friendly;web interface;web page;web site;whole health;Work;Writing;Yoga

PROJECT_TITLE: Advancing Resources for Systematic Reviews and Meta-Analyses of Complementary and Integrative Health Interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 SH (13)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Chronic Obstructive Pulmonary Disease;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Telehealth

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: LASARRUS CLINIC AND RESEARCH CENTER, INC.

ORG_STATE: MD

PHR: Narrative: This SBIR Fast-Track project proposes a groundbreaking mobile health system using a wearable multimodal sensor, WearME, to remotely monitor chronic obstructive pulmonary disease (COPD) patients, the third leading cause of death worldwide. Leveraging the expertise of our multidisciplinary team, the project aims to improve patient adherence to remote monitoring, enable early symptom detection, and reduce healthcare costs and COPD readmissions, particularly in underserved communities. By achieving FDA 510(k) clearance, we aspire to revolutionize COPD management, enhance health outcomes, and substantially impact the $117.1 billion remote patient monitoring market.

PI_NAMEs: EMOKPAE, LLOYD  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Acoustics;Activities of Daily Living;Acute;Address;Adherence;adherence rate;Agreement;Algorithms;Area;Artificial Intelligence;Award;Bilateral;Biological Markers;Biosensor;Breathing;Cause of Death;Cellular Phone;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;Clinical Research;Collaborations;commercialization;Communication;cost;cost effective;Cost of Illness;Coughing;Cross-Sectional Studies;dashboard;Data;Data Analyses;Data Collection;data management;design;Detection;Deterioration;Devices;Diagnosis;digital;Disease Management;Documentation;Dyspnea;Early Diagnosis;Ecosystem;Effectiveness;effectiveness evaluation;effectiveness study;Electrocardiogram;Engineering;Ensure;experience;Feedback;Frequencies;Goals;Health;Health Care Costs;Health Personnel;Health Professional;Health system;Healthcare Systems;Home;hospital readmission;Hour;Household;improved;Incentives;innovation;innovative technologies;Intervention;Interview;kinematics;Legal patent;Longitudinal Studies;Low income;Machine Learning;Maps;Marketing;Measurement;Measures;Medical;meetings;member;mHealth;Mid-Atlantic Region;Modality;Modeling;Monitor;Movement;multidisciplinary;multimodal data;multimodal fusion;multimodality;Notification;novel;novel strategies;Outcome;Pathway interactions;Patient Care;Patient Compliance;patient engagement;Patient-Focused Outcomes;Patients;Phase;Physical Function;Physiological;Positioning Attribute;Preparation;Production;programs;Protocols documentation;Provider;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Quality of life;Questionnaires;readmission rates;recruit;Reference Standards;Regulatory Pathway;remote monitoring;remote patient monitoring;Research;Respiration;respiratory;respiratory health;Respiratory Sounds;Role;Rural Community;Scientist;sensor;Severity of illness;signal processing;Small Business Innovation Research Grant;software development;Specialist;Specificity;Sputum;Stethoscopes;Surveys;Symptoms;System;Testing;Time;trend;underserved community;Underserved Population;United States Food and Drug Administration;United States National Institutes of Health;usability;Vital capacity;Vital capacity measurement;Walking;wearable device;wearable sensor technology;Wheezing;wireless

PROJECT_TITLE: Bilateral Acoustic Sensing and Automated Breathing Segmentation for Remote Monitoring of Patients with COPD: A Longitudinal Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (11)]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Pain;Clinical Research;Complementary and Integrative Health;Health Services;Pain Research;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE On behalf of the NIH-DOD-VA Pain Management Collaboratory (PMC), the Pain Management Collaboratory Coordinating Center (PMC3) will continue to provide national leadership and serve as a national resource for development and refinement of innovative tools, best practices, and other resources in the conduct of high impact pragmatic clinical trials (PCTs) on nonpharmacological approaches for pain management and other comorbid conditions in Veteran or military healthcare systems. In the next six-year continuation phase of the PMC, we will support the successful completion and widespread dissemination and implementation activities of the originally funded PCTs, support the successful enactment of new PCTs, and continue to generate new knowledge and resources in the service of improving the design and conduct of future PCTs.

PI_NAMEs: BRANDT, CYNTHIA A.;KERNS, ROBERT D (contact);PEDUZZI, PETER NATALE

PROJECT_TERMS: Acceleration;Achievement;Address;Adopted;Adoption;Area;Caring;clinical care;collaboratory;Communication;Communities;comorbidity;COVID-19 pandemic;Data;data harmonization;Department of Defense;design;Development;Dissemination and Implementation;Electronic Health Record;Enrollment;Ensure;Ethics;evidence base;experience;Family;Funding;Future;Geography;Goals;Government Agencies;Guidelines;Health;health care delivery;health care settings;Health Personnel;Healthcare Systems;High Prevalence;improved;Infrastructure;innovation;Integrative Medicine;Knowledge;Leadership;Military Personnel;military service;military veteran;National Center for Complementary and Integrative Health;Nonpharmacologic Therapy;Pain;Pain management;Participant;Pathway interactions;Patients;Peer Review;Personal Satisfaction;Persons;Phase;Policies;Population;Positioning Attribute;Pragmatic clinical trial;pragmatic trial;Protocols documentation;Public Health;Publishing;Recommendation;recruit;Request for Proposals;Research;Research Design;Resource Development;Resources;restoration;Sampling;service member;Services;success;symposium;System;tool;United States Department of Veterans Affairs;United States National Institutes of Health;Update;Veterans;web site;Work;working group

PROJECT_TITLE: NIH-DOD-VA Pain Management Collaboratory Coordinating Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 MH (07)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: Project narrative Somatic mutations that alter the 3D proteome and molecular pathways drive the malignant transformation of single cells. Here, we develop a novel protein footprinting technology to determine aberrations in protein conformation and protein-protein interactions in single cancer cells. Understanding the heterogeneity of the 3D proteome in tumors at a single cell resolution might allow us to find out why anti-cancer drugs only partially inhibit cell growth in a tumor.

PI_NAMEs: YATES III, JOHN R (contact)

PROGRAM_OFFICER_NAME: KYI, CINDY WIN

PROJECT_TERMS: 3-Dimensional;anti-cancer;Antineoplastic Agents;Biotin;cancer cell;Cancer cell line;Cancer Detection;cancer therapy;Cell Fraction;cell growth;Cell Line;Cell Separation;cell transformation;cell type;Cells;Chemicals;Clone Cells;conformational alteration;Detection;Diagnosis;DNA sequencing;drug action;Encapsulated;Future;Gene Expression Profile;Genetic;Goals;Growth;Heterogeneity;Hydrogels;Individual;Injections;Label;Lysine;Malignant - descriptor;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;MCF10A cells;Measurement;Measures;Methods;Modification;Molecular;Molecular Conformation;Mus;Mutate;neoplastic cell;novel;Oncogenes;Oncogenic;Paint;Pathway interactions;Peptides;Pharmaceutical Preparations;Phosphatidylinositols;Phosphotransferases;PIK3CA gene;Point Mutation;Polymers;Population;Preparation;Process;Protein Conformation;protein folding;Protein Footprinting;protein protein interaction;protein structure;Proteins;Proteome;Proteomics;Protocols documentation;Research;Resolution;Sampling;single cell analysis;Site;Solid Neoplasm;Somatic Mutation;Statistical Data Interpretation;Subcellular Fractions;Surveys;Techniques;Technology;transcriptome sequencing;Treatment outcome;Treatment Protocols;tumor;tumor heterogeneity;Tumor Suppressor Proteins;Tumor Tissue;Variant

PROJECT_TITLE: 3D Proteomics at Single Cell Resolution with Covalent Protein Painting (CPP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-D (M2)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Breastfeeding, Lactation and Breast Milk;Dementia;Gene Therapy;Genetics;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: PROSPECT

ORG_NAME: 3P BIOTECHNOLOGIES, INC.

ORG_STATE: KY

PHR: Narrative (Public Health Relevance Statement)  In the proposed project, we will use a novel nano formulation of small interfering siRNA to mitigate neuroinflammation and attenuate neurological diseases including Alzheimer's disease (AD). In our approach, siRNA of the key inflammation regulator, NFκB (siNFκB) is sequestered in exosomes (native nanoparticles) isolated from standardized bovine colostrum powder, the exosomes are attached to folic acid to target the brain sub tissues such as cortex and hippocampus, and the formulation is delivered trans-spinally by topical application for efficient brain targeting. The novel formulation will be optimized using mouse cell lines and the trans-spinal delivery system tested using mouse models for inflammation and AD.

PI_NAMEs: GUPTA, RAMESH C (contact);WALLEN, RENA MARGARET

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;Animal Model;Animals;Area;Attenuated;Base Sequence;Behavior assessment;Behavioral;beta-site APP cleaving enzyme 1;Biodistribution;Biological Markers;blood-brain barrier crossing;Brain;Brain region;candidate identification;Cattle;Cell Line;Cells;Colostrum;cost effective;Coupled;Data;Disease;Disease Marker;Dose;Drug Delivery Systems;Drug Targeting;Dryness;Dyes;efficacy study;efficacy testing;Encephalitis;Euthanasia;ex vivo imaging;exosome;experience;FDA approved;Female;Fibroblasts;Fluorescence;folate-binding protein;Folic Acid;FOLR1 gene;Formulation;Gene Expression;Gene Targeting;Genes;Goals;Hippocampus;imager;immunogenicity;immunotoxicity;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory marker;inflammatory modulation;Inflammatory Response;innovation;Intravenous;knock-down;Label;Lead;Liver;Mediating;Mouse Cell Line;mouse model;Mus;nanoformulation;nanoparticle;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;novel;Persons;Pharmaceutical Preparations;Phase;Polyethyleneimine;Powder dose form;public health relevance;Radiolabeled;Reagent;Regimen;Research;Research Personnel;Rodent;Route;safety assessment;Signal Transduction;siRNA delivery;Small Interfering RNA;Source;Spinal;Standardization;Sum;System;targeted delivery;Testing;Therapeutic;therapeutic siRNA;Tissue imaging;Tissues;Topical application;Toxic effect;Treatment Efficacy;treatment response;vector

PROJECT_TITLE: Targeted Exosomal Delivery of siRNA Therapeutics for Neuroinflammatory Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-P (11)]


ORG_CITY: SAN DIEGO

ORG_NAME: 3DT HOLDINGS, LLC

PHR: NARRATIVE Enhancement of valve durability to meet the increasing life expectancy and size reduction of the delivery system of transcatheter valves are now the major focus of the design of TAVR for the treatment of aortic stenosis. The goal of this study is to develop and validate bovine PVP served as a new type of leaflet tissue of TAVR in a chronic sheep model.

PI_NAMEs: GUO, XIAOMEI ;KASSAB, GHASSAN S;KELLEY, GREGORY S (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Acceleration;Adolescent;Animal Model;Animals;aortic valve;aortic valve replacement;Aortic Valve Stenosis;Arteries;Biocompatible Materials;Bioprosthesis device;Blood Vessels;calcification;Calcium;Catheters;Cattle;Cells;Chronic;Clinical;Clinical Research;Collagen Fiber;comorbidity;Computer Simulation;Data;design;Diameter;Elasticity;Elderly;Failure;Family suidae;Femur;Fibrosis;Functional disorder;Goals;Growth;Heart Valves;hemodynamics;immune activation;Immune system;Implant;improved;in vivo;Infiltration;Inflammatory;Life Expectancy;Lipids;Location;Longevity;Lung;Marketing;mechanical properties;Mechanical Stress;Mechanics;new technology;next generation;older patient;Operative Surgical Procedures;Outcome;patient population;Patients;Pattern;Performance;Pericardial body location;pericardial sac;Periodicity;Peripheral;Peripheral arterial disease;Phase;phase 1 study;Platelet aggregation;Play;pressure;Procedures;programs;Property;Prosthesis;Publishing;Pulmonary valve structure;Reporting;Resistance;Risk;Risk Reduction;Role;Safety;Sheep;sheep model;Small Business Innovation Research Grant;Stress;success;surgical risk;System;Testing;Thick;Thinness;Thrombosis;Tissues;Treatment outcome;Unfavorable Clinical Outcome;valve replacement;Venous;Visceral pleura

PROJECT_TITLE: Low Profile Transcatheter Aortic Valve Implant

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (11)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE RNA is a central regulator of cell biology, canonically considered an intracellular regulator, unable to directly interface with the extracellular space. Bolstered by recent evidence of cell surface RNAs and glycosylated RNAs, as well as long-standing but poorly characterized examples of a small set of cell surface RNA binding proteins, we aim to define a new paradigm, one where RNA biology is a common and functional component of the cell surface. Our work will establish foundational tools, mechanisms, and functions for cell surface RNA biology, enabling others to build on our observations and update the molecular models of what molecules are present on the surface of cells.

PI_NAMEs: FLYNN, RYAN ALEXANDER (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Address;Area;Award;Biochemical;Biological;Biological Process;Biology;Biophysics;Cell Communication;Cell model;Cell Physiology;Cell surface;Cell Therapy;Cells;Cellular biology;Cellular Structures;Communication;Data;design;Disease;Environment;extracellular;Extracellular Space;Foundations;Genetic;genetic approach;Glycobiology;glycosylation;Goals;Health;high risk;Homeostasis;Human;human disease;Immune;innovation;insight;Integral Membrane Protein;Intracellular Space;Investigation;Knowledge;Ligands;Literature;Logic;Malignant Neoplasms;Mammalian Cell;Mediating;Medicine;Membrane;Messenger RNA;Modality;Molecular;molecular modeling;Motivation;novel therapeutics;Outcomes Research;pathogen;Pathogenesis;Pathway interactions;Penetration;Peptides;Post-Translational Protein Processing;Process;Proteins;Proteome;Publishing;Regulation;repaired;Reporting;Reproducibility;Research;RNA;RNA Binding;RNA-Binding Proteins;RNA-Protein Interaction;Series;Signal Transduction;Small Interfering RNA;small molecule;sound;Surface;System;Technology;Therapeutic;Tissues;tool;Update;Work

PROJECT_TITLE: Functional characterization of cell surface RNA biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Q (70)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_DEPT: BIOCHEMISTRY

PHR: NARRATIVE The proposed research aims to engineer cells with force-responsive molecular devices that can modulate cell differentiation and T cell-based immune response. The results could lead to new strategies that improve cancer treatment and regeneration. Thus, this work is relevant to the NIH’s mission to reduce illness and disability.

PI_NAMEs: BERRO, JULIEN  (contact);GREEN, ALEXANDER ARTHUR;SU, XIAOLEI

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Affect;Antigens;Antitumor Response;Basic Science;Binding;Biochemical;Biological Factors;Biological Process;Biology;cancer immunotherapy;cancer therapy;Catalytic RNA;Categories;Cell Adhesion;cell behavior;Cell Communication;Cell Differentiation process;cell motility;Cell Physiology;Cell Therapy;Cells;Cellular biology;cellular engineering;Chemicals;Chromatin;Chromosome Pairing;Chromosome Segregation;Complement;Development;Devices;digital;disability;Disease;Elements;Engineering;Environment;Event;exhaustion;experimental study;extracellular;Extracellular Matrix;Fibroblasts;force sensor;Foundations;Gene Expression;gene therapy;Health;immune activation;Immune response;improved;innovation;insight;interest;Ligands;Malignant Neoplasms;mechanical force;mechanical signal;Mechanics;mechanotransduction;Mediating;Mediator;Messenger RNA;Mission;Mitosis;Mitotic spindle;Molecular;Molecular Conformation;Monitor;Morphogenesis;Natural regeneration;novel strategies;novel therapeutics;Organ;Output;Peptide/MHC Complex;Peptides;Pharmacotherapy;Play;Process;Production;programs;Property;Protein Engineering;protein expression;Proteins;Receptor Activation;receptor binding;regenerative therapy;Research;response;RNA;RNA Binding;Role;sensor;Signal Transduction;stem cell differentiation;Stimulus;synthetic biology;System;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Technology;Tertiary Protein Structure;Therapeutic;therapeutic development;tissue regeneration;Transducers;tumor;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: Programming cellular behavior by mechanical forces


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: WATERLOO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF WATERLOO

ORG_STATE: ON

ORG_ZIPCODE: N2L 3G1

PHR: Project Narrative We are developing two-photon excited fluorescence ophthalmoscopy as a non-invasive, cellular-scale imaging tool to assess in the living eye two functions important for retinal health: the visual cycle and cellular metabolism. Changes with TPEFO properties of excited retinal fluorophores will be measured in response to visual stimulation under normal conditions and, as an analogue to retinal disease, with systemic hypoxia. In future, this new imaging modality may help improve understanding of early disease processes, diagnosis of retinal disease, monitoring of disease progression, and evaluation of treatment efficacy.

PI_NAMEs: HUNTER, JENNIFER J (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: absorption;adaptive optics;Aerobic;Affect;All-Trans-Retinol;analog;Animal Model;Anterior;Binding;Biochemical Process;calcium indicator;Cell Physiology;Cell Respiration;Cells;Characteristics;Cone;Diagnosis;Disease;Disease Progression;Dyes;Early Diagnosis;Engineering;Environment;Enzymes;Equilibrium;Evaluation;experimental study;Eye;Fluorescence;fluorophore;Functional disorder;Functional Imaging;Funding;Future;Ganglion Cell Layer;Generations;Glaucoma;Goals;Grant;Health;high resolution imaging;Human;Hypoxia;Image;Imaging Device;imaging modality;improved;in vivo;Individual;Inner Plexiform Layer;innovation;insight;Kinetics;Leber's Hereditary Optic Neuropathy;Light;Light Adaptations;Macaca;Macular degeneration;Measurement;Measures;Metabolic;Metabolism;Methodology;Methods;Mitochondria;Modality;Modeling;Molecular;molecular dynamics;Monitor;Monkeys;Mus;NADH;Neurons;Ophthalmoscopes;Ophthalmoscopy;Optics;oxidation;Oxidation-Reduction;Photic Stimulation;Photons;Photoreceptors;Physiology;Pre-Clinical Model;Primates;Process;Production;Property;Research;Resolution;response;Retina;Retinal Diseases;Retinal Ganglion Cells;retinal imaging;Retinoids;Rod;Scanning;Testing;Time;tool;Treatment Efficacy;Treatment outcome;two-photon;Variant;Vision;visual cycle;Visualization;Work

PROJECT_TITLE: High Resolution Functional Imaging of the Retina


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative

ORG_CITY: Research Triangle Park

ORG_NAME: EPICYPHER, INC.

ORG_STATE: NC

PHR: NARRATIVE  Aging and neurodegenerative diseases, such as Alzheimer’s disease and related dementias (AD/ADRD), are associated with alterations in nuclear structure, chromatin dysregulation, genome instability, and transcriptome changes. Chromatin associated RNAs (caRNAs) are intimately associated with the regulation and maintenance of genome organization and transcription, but no high-throughput and standardized methods exist to characterize caRNAs at features of interest. Here, EpiCypher is developing a highly sensitive and scalable platform to identify caRNAs at targeted features to accelerate the discovery of aging and AD/ADRD biomarkers and therapeutic targets.

PI_NAMEs: HUNT, SABRINA ROBIN (contact);VENTERS, BRYAN J

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Acceleration;Address;Adoption;age acceleration;age related changes;age-related disease;Aging;aging related;Alzheimer's disease related dementia;Bar Codes;Bioinformatics;Biological Assay;Biological Markers;Cancer Center;cell type;Cells;Chromatin;Chromatin Structure;commercial launch;commercialization;Data;data analysis pipeline;data integration;data standards;design;Development;Disease Marker;Epigenetic Process;epigenomics;experimental study;Gene Expression;Genetic Transcription;Genome;Genomic Instability;genomic platform;Genomics;Histones;Immunoglobulin G;Immunoprecipitation;In Situ;innovation;interest;Link;Longevity;Maintenance;manufacture;Marketing;Messenger RNA;Methods;Monitor;Neurodegenerative Disorders;next generation;novel;novel marker;novel strategies;Nuclear;Nuclear RNA;Nuclear Structure;Nucleosomes;Pathology;Performance;Phase;Play;Poly A;Poly(A)+ RNA;Process;Proteins;Protocols documentation;Reagent;Recombinants;Regulation;Research;restoration;Reverse Transcription;RNA;RNA immunoprecipitation sequencing;Role;Services;stability testing;Standardization;Technology;therapeutic development;therapeutic target;tool;Transcript;transcriptome;Untranslated RNA;user-friendly;Validation

PROJECT_TITLE: Versatile genomics platform for unbiased analysis of chromatin-associated RNAs and nascent transcripts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-H (13)]


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: EUGENE

ORG_NAME: SAAVSUS, INC.

ORG_STATE: OR

PHR: Project Narrative Providing high-quality instruction and sufficient access to physical education (PE) in elementary schools is a national priority for improving health and educational outcomes for children. Innovative resources targeting elementary classroom teachers, who are increasingly assuming the roles of physical educators with minimal training or experience, are needed for them to deliver effective evidence- and standards-based PE. The project seeks to complete the full development of all digital app features and content of the Pocket PE 3-5TM program (begun in Phase I) for broad-scale commercialization and dissemination to elementary schools and to test initial effectiveness of the program with a diverse school-based sample in a clustered randomized trial.

PI_NAMEs: JOHNSON-SHELTON, DEBORAH ;RICCI, JEANETTE  (contact)

PROGRAM_OFFICER_NAME: BROWN, NATALIE

PROJECT_TITLE: Development, Feasibility, and Acceptability of Aim to Play, a User-Friendly Digital Application for Teacher Skills Training and Physical EducationActivities for 3-5 Grade Elementary Students

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (10)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Wound Healing and Care

ORG_CITY: SAINT PAUL

ORG_NAME: MINNESOTA HEALTHSOLUTIONS CORPORATION

ORG_STATE: MN

PHR: Project Narrative It is estimated that more than 2.5 million individuals in the United States develop pressure injuries annually. Persons living with Alzheimer's disease or a related dementia (ADRD), both in long-term care facilities and private residences, are at an increased risk for pressure injury formation. This project aims to develop an innovative chair to prevent and/or treat pressure injuries in persons living with ADRD.

PI_NAMEs: GRACI,, VALENTINA ;SEIFERT, SARA  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Adoption;age related;Aggressive behavior;Agitation;Air;Air Pressure;Alzheimer's disease related dementia;Area;base;Beds;Behavioral;Biomedical Engineering;Calibration;care providers;Caregivers;Cells;Ceramics;Cognitive;Collaborations;Confusion;cost;decubitus ulcer;Dementia;dementia care;design;Development;Devices;Discipline of Nursing;effectiveness evaluation;effectiveness testing;Energy consumption;Engineering;Epidemiologist;Equipment;Evaluation;experience;Fiber;Fright;Gel;Goals;Health care facility;Height;Home;Human;improved;Individual;Injury;injury prevention;innovation;Interview;Laws;Lifting;Liquid substance;Long-Term Care;Marketing;Mattresses;Mechanics;Minnesota;Mobility decline;Motion;Motor;neurophysiology;Noise;novel;older adult;Pain;Pathway interactions;Patients;Pediatric Hospitals;Persons;Phase;Philadelphia;Positioning Attribute;pressure;Prevalence;prevent;Prevention;Privatization;Process;professor;prototype;Provider;Qualitative Research;Recording of previous events;Research;research and development;Research Assistant;Research Methodology;residence;Risk;Safety;Sensory;skills;Skin;Specific qualifier value;Structure;Surface;System;technology intervention;Testing;Textiles;Tissues;Treatment Cost;United States;United States Agency for Healthcare Research and Quality;Universities;usability;Water;wound injury

PROJECT_TITLE: Chair to Prevent and Treat Pressure Injuries in Persons Living with Alzheimer's Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-J (10)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: San Diego

ORG_NAME: CORTECHS LABS, INC.

PHR: Project Narrative The purpose of this project is to develop clinical image analysis software which will automatically detect and quantify the amyloid related imaging abnormalities (ARIA) during the treatment of Alzheimer’s patients to monitor the effects of the therapeutic intervention, and to improve patient management. The software will use non-invasive MR images with T1, FLAIR and T2* contrasts and report the number of lesions, their volume, and their anatomical locations. These tabulated results, with the images containing highlighted ARIA lesions will help clinicians both to determine the drug response, and to decide to continue with the drug therapy.

PI_NAMEs: ULUG, AZIZ M (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: 3-Dimensional;abeta accumulation;Aducanumab;Algorithms;Alzheimer's Disease;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Anatomy;Area;Atrophic;autosomal dominant Alzheimer's disease;Blood Vessels;Brain;Brain imaging;Cerebral Amyloid Angiopathy;cerebral atrophy;Cerebral hemisphere hemorrhage;Characteristics;Clinical;clinical imaging;Computer software;Decision Making;Dementia;Deposition;Detection;Deterioration;Development;Disease;Disease Progression;Dose;Down's Syndrome;drug efficacy;Drug Monitoring;Edema;Environment;experience;Future;Genetic;Goals;Hemorrhage;Image;Image Analysis;imaging modality;imaging software;Impaired cognition;improved;Infusion procedures;Interruption;intervention effect;Lesion;Location;Magnetic Resonance Imaging;middle age;Monitor;Monoclonal Antibodies;Names;Neurofibrillary Tangles;neuron loss;Observer Variation;Output;Patient Care;Patient Monitoring;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;Physicians;Process;radiologist;rate of change;Recommendation;Reporting;response;Role;Senile Plaques;side effect;Siderosis;software development;success;Symptoms;Therapeutic Effect;Time;Titrations;tool;Training;treatment response;usability;validation studies;vasogenic edema;Visual;web services

PROJECT_TITLE: Quantification of ARIA During the Treatment of Alzheimer's Patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-C (10)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW YORK

ORG_NAME: IN VIVO ANALYTICS, INC.

ORG_STATE: NY

PHR: Project Narrative: InVivo Analytics seeks funding for developing a cloud-based platform for biodistribution analysis of small animal positron emission tomography (PET). Biodistribution analysis is currently operator-dependent, time-consuming, and prone to error while reducing the reproducibility of study results. The proposed technology will be fully automated, operator-independent, and will facilitate the development of new drugs in small animal models of cancer.

PI_NAMEs: KLOSE, ALEXANDER D. (contact)

PROGRAM_OFFICER_NAME: FRANCA-KOH, JONATHAN C

PROJECT_TERMS: Acceleration;Address;Anatomy;Animal Cancer Model;animal imaging;Animal Model;Animals;Atlases;Automation;Biodistribution;Biological Sciences;Biotechnology;Body Size;cancer imaging;cancer therapy;Clinical Trials;cloud based;cohort;commercial application;Commercial grade;commercialization;Complex;Computer software;Consumption;contrast enhanced;contrast imaging;Contrast Media;cost;Cryoultramicrotomy;Data;Data Analyses;data platform;data sharing;Data Sources;data visualization;design;Development;digital;Digital Imaging and Communications in Medicine;drug development;Drug Industry;Early treatment;Ensure;fluorodeoxyglucose;Funding;Generations;Geometry;Goals;Hour;Image;imaging platform;imaging study;imaging system;improved;in vivo;Industry;Injections;Institution;interest;kinetic model;Kinetics;Knowledge;large scale data;Letters;Limb structure;Location;Lung;Manuals;Maps;Measures;Molds;Monitor;Mus;novel;novel therapeutics;Organ;Outcome;Pharmacotherapy;Phase;Play;Plug-in;Positioning Attribute;Positron-Emission Tomography;pre-clinical;preclinical imaging;Probability;radiotracer;Reporting;Reproducibility;Research;respiratory;Role;Scanning;Skeleton;soft tissue;software as a service;Standardization;System;Technology;therapeutic candidate;therapy development;therapy outcome;Time;Time Study;Tissues;tool;Translations;tumor;tumor xenograft;uptake;X-Ray Computed Tomography

PROJECT_TITLE: Automatic SUV Extraction and Biodistribution Analysis of Preclinical PET

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (10)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Contraception/Reproduction;HIV/AIDS;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE: Effective antiretroviral therapy (ART) is critical during pregnancy for women living with HIV (PWHIV) for optimal maternal and fetal health, but there are knowledge gaps in pharmacology of new HIV drugs, adverse effect profile, and safety in pregnancy that prevent efficient and effective deployment of our most promising new ART in pregnant women. The objective of this proposal is to advance our knowledge of adverse effect profile associated with -- Dolutegravir (DTG), Tenofovir Disoproxil Fumarate (TDF), and Lamivudine drug combination --in PWHIV and their offspring, using advanced “omics” technologies (integrated proteomics and metabolomics). Research goals include clinical and biomarker characterization of metabolic syndrome, and providing insights into the mechanistic intricacies of metabolic syndrome in large community-based cohorts of black and white PWHIV in the US and Nigeria, with the overall goal of optimizing HIV therapeutics for PWHIV.

PI_NAMEs: EKE, AHIZECHUKWU C. (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Address;Admission activity;Adult;Adverse effects;antiretroviral therapy;Biological Markers;biomarker identification;Blood Pressure;Blood Proteins;Cesarean section;Child;Cholesterol;Clinical;clinical practice;cohort;Communities;comparison control;Country;Data;Development;Drug Combinations;Early Diagnosis;Education;excessive weight gain;fetal adiposity;Fetal health;Fumarates;Gestational Diabetes;Glucose;Goals;Health;HIV;HIV diagnosis;individualized medicine;Infrastructure;insight;Intervention;Knowledge;Lamivudine;Low Birth Weight Infant;Maternal Health;Measures;Metabolic;Metabolic dysfunction;Metabolic syndrome;metabolomics;Neonatal Intensive Care Units;Nigeria;Obesity;offspring;perinatal HIV;personalized medicine;Pharmaceutical Preparations;Pharmacology;Postpartum Period;Postpartum Women;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnant Women;Premature Birth;prevent;Prevention;programs;Prospective, cohort study;Proteins;Proteomics;Regimen;Research;Risk;Safety;Serum;Site;Special Population;Symptoms;Techniques;Technology;Tenofovir;Therapeutic;transmission process;Treatment Efficacy;Umbilical Cord Blood;United States;United States National Institutes of Health;waist circumference;Weight Gain;Woman;Women's Health

PROJECT_TITLE: Integrated proteomic and metabolomic biomarker profiling for understanding metabolic syndrome in pregnant women living with HIV on Tenofovir Disoproxil Fumarate/Lamivudine/Dolutegravir (TLD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-P (55)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pain Research;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: SOOVU LABS INC

ORG_STATE: WA

PHR: Narrative Alcohol use disorder (AUD) affects millions of people in the Unites States. Stress and anxiety in those with AUD increase the chance of relapse. In this application Soovu Labs examines a new method of treating stress and anxiety by direct stimulation of targets in the peripheral nervous system specifically TRPV-1 channels and C tactile fibers, and will create a new drug free device to support those with AUD.

PI_NAMEs: CHABAL, CHARLES  (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Address;Affect;alcohol abuse therapy;alcohol seeking behavior;alcohol use disorder;Animal Experimentation;Anxiety;anxiety management;anxiety reduction;anxiety symptoms;appendage;Behavioral;biological adaptation to stress;Biological Markers;Capital Financing;Clinical;Clinical Trials;commercialization;Control Groups;cost;craving;Data;Development;Devices;Dropout;efficacy evaluation;experimental group;Feeling;Fiber;Filament;Flare;Foundations;Funding;Heating;hedonic;Human;human subject;Hydrocortisone;Individual;Intervention;Laboratory Finding;Light;Link;Location;Mammals;Measurement;Measures;Medical Device;Methods;Modeling;Neurologic;non-drug;novel;novel therapeutics;Oxytocin;Pain;pain relief;Pathway interactions;Peripheral;Peripheral Nervous System;Personal Satisfaction;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Physical Stimulation;Placebos;Population;potential biomarker;power analysis;preference;pressure;programs;Psyche structure;Publishing;Randomized;receptor;Recording of previous events;Relapse;Research;response;Risk;Salivary;Skin;Small Business Innovation Research Grant;Standardization;Stress;stress reduction;stressor;symptom treatment;Symptoms;System;Tactile;Telephone;Temperature;Testing;Time;tool;Touch sensation;transmission process;TRPV1 gene;United States;wearable device

PROJECT_TITLE: Treating stress and anxiety in individuals with alcohol use disorder (AUD) using a combination of TRPV-1 channel and C-tactile fiber activation with measurement of oxytocin and cortisol levels


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: TROY

ORG_NAME: APPLIED BIOPHYSICS, INC.

PHR: An Impedance-based Cell Assurance Monitor The SBIR project involves research to develop, evaluate and fabricate an instrument for biomedical research laboratories using cells in tissue culture. Referred to as the ECIS Cell Assurance Monitor, the device will combine an electrical impedance measurement with novel statistical feature selection and classification algorithms to assist researchers in confirming the identity and nature of cultured cells used in their scientific studies.

PI_NAMEs: KEESE, CHARLES R (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: 3-Dimensional;Algorithmic Software;Animals;base;Biomedical Research;Biophysics;cell behavior;Cell Culture Techniques;Cell Line;cell type;Cells;Cellular Morphology;Classification;classification algorithm;Collaborations;college;commercialization;Complement;Complex;Computer software;Cultured Cells;Data;data acquisition;Data Analyses;design;Development;Device or Instrument Development;Devices;electric impedance;Electrodes;Electronics;Epigenetic Process;Epithelium;Failure;Feasibility Studies;feature detection;feature selection;Frequencies;Funding;Hela Cells;innovation;instrument;interest;Laboratories;Laboratory Research;Maps;Marketing;Measurement;Mesenchymal;Methods;microorganism;Microscopic;Monitor;monitoring device;Morphology;Mycoplasma;Mycoplasma Infections;Nature;novel;Organism;Pattern;Phase;Population;Positioning Attribute;Protocols documentation;Publishing;Reporting;Reproducibility;Research;Research Personnel;research study;Signal Transduction;Small Business Innovation Research Grant;software development;Source;Spottings;Statistical Data Interpretation;statistics;success;System;Techniques;Technology;Testing;Time;tissue culture;Tissues;tool;Universities;Variant;Visual;wasting

PROJECT_TITLE: Development of an impedance-based cell assurance monitor to aid in identifying and characterizing cells in tissue culture

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (12)]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: ENZYME BY DESIGN, INC.

ORG_STATE: IL

PHR: Project Narrative: L-asparaginases (ASNases), which are essential drugs for treating pediatric acute lymphoblastic leukemia (ALL), also have tremendous potential for use in adults with ALL – as well as other indications including both solid and blood tumors – were it not for the severe toxicity seen with today’s FDA-approved ASNases, especially when given to adults. In previous work, we developed a novel mammalian ASNase, EBD-300, that is significantly better tolerated than the currently approved bacterial versions, while still maintaining the same high efficacy. In this application, we will engineer a next generation version of EBD-300 to have a significantly longer in vivo persistence, which is an essential property for this drug to become the most impactful in 1st line ALL treatment and in the treatment of additional cancers comprising mainly adults where patients can be selected based on biomarkers for sensitivity to asparagine depletion.

PI_NAMEs: SCHALK, AMANDA M (contact)

PROGRAM_OFFICER_NAME: ZANE, LINDA KARINE

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Address;Adult;Adult Acute Lymphocytic Leukemia;anti-cancer;anti-cancer therapeutic;asparaginase;Asparagine;B-Cell Acute Lymphoblastic Leukemia;Biological;Biological Markers;Biological Products;Bioluminescence;Blood;Body Weight decreased;C-terminal;Cancer Patient;cancer therapy;Cavia;Cessation of life;Childhood;Childhood Acute Lymphocytic Leukemia;Clinical;clinical application;clinical efficacy;Clinical Trials;Colorectal Cancer;cross reactivity;de-immunization;Depressed mood;Disease;Dose;drug clearance;Drug usage;Endotoxins;Endowment;Engineering;Enzymes;Escherichia coli;Essential Drugs;FDA approved;Flow Cytometry;Formulation;Frequencies;Gel;Glutaminase;Glutamine;Goals;Half-Life;Hematopoietic Neoplasms;Homeostasis;human model;Hypersensitivity;immunogenicity;Immunologics;improved;in vivo;Interview;Lead;Length;leukemia;leukemia treatment;Life Extension;Malignant Childhood Neoplasm;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Metabolic;meter;Minority;Modification;mouse model;Mus;neoplastic cell;next generation;novel;Patients;Pectobacterium chrysanthemi;Pegaspargase;Pharmaceutical Preparations;Phase;Photometry;Population;pre-clinical;prevent;Primary carcinoma of the liver cells;Process;programs;Proliferating;Property;Proxy;Risk;Risk Reduction;Safety;Schedule;side effect;Signal Transduction;Solid;Solid Neoplasm;Starvation;statistics;stem;success;T-Lymphocyte;Technology;Testing;timeline;Toxic effect;Treatment Protocols;tumor;uptake;Variant;Work

PROJECT_TITLE: Engineering in vivo half-life extension of a novel mammalian asparaginase to increase feasibility of pan-cancer therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-R (12)]


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Lymphatic Research;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Narrative: Kaposi's Sarcoma Herpesvirus (KSHV) is the etiologic agent of Kaposi's Sarcoma, the most common tumor of AIDS patients worldwide. While KSHV is an oncogenic virus little is known about how KSHV initiates growth and cancer formation. These studies will determine the mechanism of KSHV induction of the first steps of tumor cells formation in lymphatic endothelial cells, a cell type relevant to KS tumor cells, leading to better avenues to treat KS tumors through specific inhibition of KS tumor cell proliferation.

PI_NAMEs: LAGUNOFF, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Africa South of the Sahara;Agar;Biological Assay;Blood;Bypass;cancer cell;Cancer Etiology;CDKN2A gene;Cell Aging;Cell Cycle;Cell model;Cell Proliferation;Cell Separation;cell type;Cells;Common Neoplasm;Country;Data;Developing Countries;Endothelial Cells;Endothelium;Episome;Etiology;Gene Expression;Genes;Grant;Growth;Herpesviridae Infections;HIV;Homologous Gene;Human;Human Herpesvirus 8;Immune;Infection;infection rate;interest;Interferons;Kaposi Sarcoma;Knock-out;Licensing;Lymphatic;Lymphatic Endothelial Cells;Lymphatic Endothelium;Malignant Neoplasms;Mediating;Morbidity - disease rate;mortality;Neonatal;neoplastic cell;NF-kappa B;novel therapeutics;Oncogenes;Oncogenic;Oncogenic Viruses;Opportunistic Infections;overexpression;Pathway interactions;Patients;Persons;Phenotype;Phosphorylation;Plasma;Play;podoplanin;precursor cell;Predisposition;prevent;Proliferating;Publishing;recombinant virus;Recombinants;Reporting;Reproducibility;response;Retinoblastoma Protein;Role;senescence;sensor;Sepsis;Signal Transduction;Spindle Cell Sarcomas;System;Testing;tumor;tumorigenesis;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factor Receptor-3;Vascular System;Viral;viral cyclin;Viral Genes;Virus;virus episome maintenance

PROJECT_TITLE: KSHV immortalization of human lymphatic endothelial cells

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PUBLIC HEALTH RELEVANCE STATEMENT This study examines how oral Actinobacteria maintain proper folding of virulence factors during their assembly and under stress conditions. A clear understanding of these aspects will provide new targets for anti-infective therapies and prevention of oral biofilm-associated diseases.

PI_NAMEs: TON-THAT, HUNG  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Actinobacteria class;Actinomyces;Address;Adhesives;Anabolism;Anti-Infective Agents;Attenuated;Binding;Biochemical;Biological Assay;Cell Physiology;Cell Wall;Cells;Cellular Morphology;Cellular Stress;Corynebacterium;Corynebacterium diphtheriae;Coupling;Crystallography;Cysteine;Defect;Disease;disulfide bond;Eukaryota;Experimental Models;Genetic;genetic approach;Gram-Negative Bacteria;Gram-Positive Bacteria;interdisciplinary approach;Isomerase;Isomerism;Mediating;Membrane;Microbial Biofilms;misfolded protein;Molecular;mutant;Mutation;Names;oral biofilm;Oral Examination;Organism;Oxidoreductase;Pathway interactions;Pilum;Prevention;Process;Prokaryotic Cells;Protein Export Pathway;protein folding;protein misfolding;Protein translocation;Proteins;Proteome;public health relevance;response;Stress;Stress and Coping;Structure;Sulfhydryl Compounds;System;Temperature;Thiol Disulfide Oxidoreductase;TXN gene;Virulence;Virulence Factors

PROJECT_TITLE: Post-translocational protein folding in Gram-positive bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-M]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE Recent studies in mice suggest that specific types of retinal ganglion cells, the neurons that degenerate in glaucoma, are more susceptible to injury. However, translating these findings to the human condition is not straightforward since the mouse and human eye differ in several major ways, including the ocular structures and types of retinal ganglion cells found in the two species. Here we propose a detailed multi-modal assessment of the mechanisms underlying ganglion cell susceptibility in a highly clinically relevant model of glaucoma, which will lead to improved understanding of the disease, novel targets for earlier diagnosis and treatment, and in turn, better options for glaucoma patients to preserve and potentially improve their vision.

PI_NAMEs: FORTUNE, BRAD ;OU, YVONNE  (contact);SIVYER, BENJAMIN M

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Adult;Affect;Anatomy;Cell Death;cell type;Cells;clinical development;clinically relevant;Communities;Data;Dendrites;density;Development;Diagnostic;Disease;Early Diagnosis;Early treatment;Electrophysiology (science);Ensure;Exhibits;Experimental Models;Eye;ganglion cell;gene therapy;Glaucoma;Goals;Human;improved;injured;Injury;innovation;insight;Knowledge;Macaca mulatta;macula;Maps;Modeling;Molecular;Molecular Analysis;Morphology;multi-electrode arrays;multimodality;Mus;Nerve Degeneration;neural circuit;neuroprotection;new therapeutic target;nonhuman primate;novel;patch sequencing;Patients;Pattern;Physiologic Intraocular Pressure;Predisposition;preservation;Primates;repaired;Research Personnel;Resources;Retina;Retinal Ganglion Cells;Rodent;sight restoration;Specificity;Staging;Structure;Synapses;Testing;Tissue-Specific Gene Expression;transcriptome;Translating;Translations;Vision

PROJECT_TITLE: Retinal circuit disassembly in primate glaucoma - Diversity Supplement


NIH_SPENDING_CATS: Bioengineering;Lung;Orphan Drug;Patient Safety;Rare Diseases

ORG_CITY: BOULDER

ORG_NAME: LAZZARO MEDICAL, INC.

ORG_STATE: CO

PHR: NARRATIVE: Acquired tracheobronchomalacia (TBM) is an under-diagnosed/misdiagnosed disease causing the airway to collapse on itself with few safe and effective treatment options that, until recently with the develop- ment of minimally invasive TBM repair (R-TBP), resulted in high morbidity, a long recovery period, and high mortality, limiting viability for broad patient treatment. Lazzaro Medical, Inc. is developing a novel LM Scaffold SystemTM to enable widespread adoption of R-TBP by reducing the technical complexity and skill necessary in current procedures that require custom fabrication of generic surgical mesh peri-operatively. The LM Scaffold device and procedure will offer an efficient and practical solution suitable for mainstream thoracic surgery facili- ties to deliver lower risk TBM surgical intervention in the hands of mainstream thoracic surgeons.

PI_NAMEs: BITZ, DAWN DAWN (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute;Adoption;Adrenal Cortex Hormones;Adult;Advanced Development;Adverse event;Airway Disease;Anatomy;arm;Asthma;Bronchi;Cadaver;canine model;Canis familiaris;Cessation of life;Chronic;Chronic Obstructive Pulmonary Disease;clinically significant;Collaborations;comorbidity;comparison control;Complex;cost;Coughing;COVID-19;Custom;data submission;Dependence;design;Development;Devices;Diagnosis;Disease;Disease Progression;economic implication;effective therapy;Evaluation;fabrication;first-in-human;Forced expiratory volume function;Freezing;Future;Geometry;Goals;Guidelines;Hand;Healthcare Systems;Histology;improved;in vivo;Inflammation;Infrastructure;Intervention;Legal patent;Link;Mainstreaming;Marketing;Medical;Medical Device;method development;Methodology;Methods;minimally invasive;Modeling;Morbidity - disease rate;mortality;National Center for Advancing Translational Sciences;Nature;novel;open innovation;Operating Rooms;Operative Surgical Procedures;Patients;Peak Expiratory Flow Rate;Perioperative;Persons;Pharmacologic Substance;Phase;Population;preclinical efficacy;preclinical safety;preclinical study;Prevalence;Procedures;Process;product development;prototype;pulmonary function;reconstruction;Reconstructive Surgical Procedures;Recovery;repaired;Risk;Robotics;Safety;safety study;sample fixation;scaffold;sheep model;Shortness of Breath;skills;Small Business Innovation Research Grant;soft tissue;Specific qualifier value;Speed;Surgical Mesh;Surgical sutures;System;Thoracic Surgeon;Thoracic Surgical Procedures;Time;Trachea;Tracheobronchomalacia;Validation;Ventilator;Vital capacity

PROJECT_TITLE: Lazzaro Medical Scaffold System for improved treatment of tracheobronchomalacia


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Emerging Infectious Diseases;Infectious Diseases;Patient Safety;Prevention

ORG_CITY: MIDDLETON

ORG_NAME: IMGGYD LLC

ORG_STATE: WI

PHR: Current drapery solutions for MRI, CT, and PET scanners are inconvenient to install, prone to failure during use, and can impede image-guided procedures. An important application for drapery for radiological scanners is Emergency Room- based scanners, which can become soiled and unusable for 1-2 hours. Finally, with a recent rise in Hospital-Acquired Infection (HAI), the International Society for Infectious Disease recommends use of a disposable plastic barrier changed between each patient as a best practice for preventing infectious in the radiology department. Our product, Saf-T-Drape, is a semi-rigid liner for the scanner bore that is easily installed, easily disposed, economical for single-patient use, robust against patient movement, and does not interfere with procedures. We propose designing and building prototypes, and testing them in realistic clinical environments. We will examine the effect on image quality for MRI and CT images, we will test the ability of Saf-T-Drape to mitigate scanner-patient cross infection, and we will examine usability and durability factors. The goal is to characterize Saf-T-Drape with regard to image quality, patient safety aspects, and mitigation of disease transmission, so our clinical colleagues can justify requesting approvals to test Saf-T-Drape in a realistic clinical environment.

PI_NAMEs: OAKES, TERRENCE R (contact)

PROGRAM_OFFICER_NAME: ASHMONT, KARI RICH

PROJECT_TERMS: Accident and Emergency department;Address;Adoption;Affect;Area;Beds;Body Fluids;Candida auris;Characteristics;Clinical;Clostridium difficile;Communicable Diseases;Consumption;Contracts;cost effective;Cross Infection;Deposition;design;Devices;Diagnostic radiologic examination;diagnostic tool;Disease;disease transmission;disorder prevention;Dryness;Effectiveness;Environment;Equipment;Event;Failure;Goals;Hospital Costs;Hospitalization;Hospitals;Hour;Human body;Image;image guided;Image-Guided Surgery;improved;Industry;Infection;Infection prevention;Infectious Agent;innovation;International;Interruption;Legal patent;Letters;Liquid substance;Magnetic Resonance Imaging;Maintenance;manufacture;Measurement;Measures;Medical Care Costs;Michigan;Middle East Respiratory Syndrome;minimally invasive;Modeling;Movement;multi-site trial;Nature;Neurosurgeon;Neurosurgical Procedures;Nosocomial Infections;novel;patient safety;Patients;Phase;phase II trial;Positron-Emission Tomography;Prevalence;prevent;Procedures;prototype;Radiology Specialty;Recommendation;Reporting;response;Scanning;Shapes;simulation;Societies;Soil;Source;Speed;Sterility;Surface;Surgeon;System;Testing;Time;tool;Training;Translating;usability;wasting;X-Ray Computed Tomography

PROJECT_TITLE: Saf-T-Drape: Sterile Drapery Shielding for Radiological Scanners


ORG_CITY: BROOMFIELD

ORG_NAME: FLUOROFINDER, LLC

PHR: PROJECT NARRATIVE Flow cytometry is an essential tool in modern cellular and molecular biology, where the technique is critical in a variety of applications including the diagnosis of cancer and complex cellular assays in pharmaceutical develop- ment and medical research, amongst many others. However, the design and development of modern cytometry experiments is highly complex and error prone. In this project, FluoroFinder will advance development of the IntelliPanel to automatically generate reliable flow cytometry panels tailored to a user’s experimental and instru- ment configurations to yield significant time and cost savings, reduce or eliminate design errors, and lower the barrier to entry for developing successful flow cytometry experiments.

PI_NAMEs: YOUNG, DAREN  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Acceleration;Advanced Development;Affect;Antibodies;Antigens;Autoantigens;Biological;Biological Assay;cancer diagnosis;Cell Differentiation process;cell type;Cells;Cellular Assay;Cellular biology;Characteristics;Color;Communities;Complex;Computer software;cost;Cost Savings;Cytometry;Data;Databases;density;design;Detection;Development;Elements;Emerging Technologies;Ensure;experience;Experimental Designs;experimental study;Flow Cytometry;fluorophore;Generations;Human;Image Cytometry;Immunofluorescence Immunologic;improved;indexing;instrument;instrumentation;journal article;Knowledge;Medical Research;Modeling;Modernization;Molecular Biology;novel;Nuclear;Output;Pattern;Peer Review;Performance;Pharmacologic Substance;Phase;Phenotype;Population;pre-clinical;Process;Publications;Publishing;Reagent;Recommendation;Reproducibility;research and development;Research Design;Resolution;Sampling;Site;Standardization;Surveys;System;Techniques;Testing;Time;tool;United States National Institutes of Health;user-friendly;Validation;wasting;Weight;Work

PROJECT_TITLE: Improved flow cytometry panel design with a novel automated panel design system

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (14)]


ADMINISTERING_IC: CK

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project narrative: This proposal entitled "Defining the epidemiology, diagnosis, prevention, and treatment of invasive fungal infections in the United States" is a broad and ambitious project which seeks to enhance the overall understanding of invasive mycoses in the general population, but also in individuals who are at enhanced risk of complications from these infections. The project will be coordinated through the MSG Central Unit located at the University of Alabama at Birmingham, and will involve the participation of a large number of clinical and laboratory investigators from centers across the country who share the specific interest in clinical mycology. The overarching goal of this project is to reduce morbidity and mortality of invasive fungal infections through greater understanding of their epidemiology, risk factors for acquisition, and specific interventions which might lead to better overall outcomes for individuals with these complex infections.

PI_NAMEs: PAPPAS, PETER GEORGE (contact)

PROJECT_TITLE: RFA-CK-23-001, Clinical and Applied Research Strategies for the Prevention and Control of Fungal Diseases


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE We lack knowledge on the health status of hotel housekeepers (HHs) hired through Non-Standard Work Arrangement (NSWA). To address this federally identified gap and in response to PAR-18-797 we propose to conduct a mixed-method study which aims to 1) Describe the health status of HHs hired through NSWA compared to those hired through Standard Work (SW), and 2) to understand the lived experiences of HHs hired through NSWA. This line of inquiry is well aligned with NIOSH’s Healthy Work Design and Well-Being program which identified NSWA as one of its three priority areas.

PI_NAMEs: ROSEMBERG, MARIE-ANNE SANON (contact)

PROGRAM_OFFICER_NAME: LIOCE, MARIA

PROJECT_TITLE: Non-Standard Work Arrangements, Health and Wellbeing Among Hotel Housekeepers

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: CHARLOTTE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

PHR: PROJECT NARRATIVE Diabetes is a common chronic condition, affecting an estimated 34.1 million adults, or 13% of all U.S. adults age 18 and older; it also disproportionately affects individuals with lower education and socio-economic status. Diabetes treatment adherence is critical for preventing complications; yet research on diabetes management behaviors does not consider necessary work design factors that may inhibit adherence. This study will assess work-related factors that may lead to work-health management interference, diabetes self-management, and work ability in U.S. full-time blue-collar and service sector workers with diabetes.

PI_NAMEs: MCGONAGLE, ALYSSA KATE (contact)

PROJECT_TITLE: Work Design, Self-Management, and Work Ability in Workers with Diabetes


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Neurodegenerative;Neurosciences;Pain Research;Patient Safety;Peripheral Neuropathy;Precision Medicine;Rehabilitation

ORG_DEPT: SURGERY

PHR: Ulnar neuropathy at the elbow is a common condition that can cause pain, tingling and muscle loss in the hand. Surgery is often recommended to eliminate symptoms but controversy exists over the best procedure. We plan to conduct a multicenter randomized clinical trial to compare outcomes for two commonly used surgical procedures and develop an optimal surgical plan for individual patients.

PI_NAMEs: CHUNG, KEVIN C (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Activities of Daily Living;Adult;Affect;Algorithms;Anterior;arm;Blinded;Characteristics;clinical research site;Clinical Trials;comorbidity;compare effectiveness;Complication;Diagnosis;disability;Disabling condition;Dissection;Double-Blind Method;Economics;effectiveness evaluation;Elbow;evidence base;evidence based guidelines;Evidence based treatment;experience;Fingers;functional outcomes;Goals;Hand;Hand functions;Hand Strength;Healthcare;Hematoma;Heterogeneity;illness length;improved outcome;In Situ;Individual;individual patient;individualized medicine;irritation;Job loss;Left;Level of Evidence;men;Meta-Analysis;Multicenter Studies;Muscular Atrophy;Natural History;Nerve;Neuropathy;novel;Numbness;Occupational;Operative Surgical Procedures;Outcome;Outcome Assessment;Pain;painful neuropathy;Paresthesia;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Physicians;Physiological;Positioning Attribute;Postoperative Complications;Postoperative Period;precision medicine;predictive modeling;preference;Prevalence;Procedures;Productivity;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Recovery;reduce symptoms;Reporting;Research;Research Personnel;Sample Size;Second Look Surgery;Severities;Severity of illness;Site;soft tissue;Structure;Structure of ulnar nerve;subcutaneous;Surgeon;surgery outcome;Surgical Management;Symptoms;Techniques;Time;Training;Treatment Effectiveness;trend;Ulnar Neuropathies;United States;Upper Extremity;Woman

PROJECT_TITLE: Clinical Trial for Surgery of the Ulnar Nerve (SUN) at the Elbow

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Sustainable interventions are needed to improve diet and cardiovascular health in American Indians (AIs). However, most efforts to improve health in AIs have been ineffective— likely due in part to an inadequate understanding of multi-level (i.e., individual- , household- , and community- level) factors that may impact diet and cardiovascular risk factors, including multi-level components of the physical environment and socio-cultural environment in rural Tribal Nations. The proposed project will generate knowledge to inform future cardiovascular health interventions by examining community-, household-, and individual-level factors on diet and cardiovascular risk in the largest and longest-ongoing multi-generational and multi-tribal cohort study of AIs from 12 rural communities in the USA.

PI_NAMEs: FRETTS, AMANDA MAE (contact)

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: Address;American Heart Association;American Indian community;American Indians;Ancillary Study;Behavioral;Biological;Biological Markers;Blood Pressure;Body mass index;built environment;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Central obesity;cohort;Cohort Studies;combat;Communities;Consumption;contextual factors;cost;Data;design;Diabetes Mellitus;Diet;Dietary Assessment;Dietary Fiber;Eating;Economic Factors;Economics;Enrollment;Environment;Family;Family Study;fasting glucose;Feasibility Studies;Fishes;Food;food environment;food insecurity;Food Preferences;food security;Foundations;fruits and vegetables;Future;Genetic;Goals;good diet;Health;Health Food;Healthy Eating;Heart;High Density Lipoprotein Cholesterol;Household;hypercholesterolemia;Hypertension;improved;Indian reservation;Individual;informant;insight;Intake;Intervention;Interview;Knowledge;Measures;member;Methods;Morbidity - disease rate;mortality;Neighborhoods;nutrition;Nutrition Assessment;Obesity;Outcome;Participant;Persons;Physical environment;Pilot Projects;Policies;programs;Psychosocial Factor;Reporting;Research;Research Activity;Reservations;Resources;Risk Factors;Role;Rural;rural Americans;Rural Community;Sampling;Smoking;social culture;social factors;Sodium;sugar;sweetened beverage;tribal community;tribal Nation;Tribes;Triglycerides;Unhealthy Diet;Urban Community;Work

PROJECT_TITLE: Understanding the Role of the Food Environment on Diet and Health in Rural American Indian Communities: the Strong Heart Food Environment Study

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE The long history of training success within the Division of PACCM at the University of Pittsburgh is now invigorated with new leadership, has a focus on fundamental biological themes and translational science, and is characterized by diverse trainees who continue to publish novel science, attain fellowship and career development awards, and transition to independent research careers. The success of this T32 will produce a new generation of scientists with the training, creativity, and resources tobe future leaders in the field of Pulmonary Biology and Medicine.

PI_NAMEs: KOENIGSHOFF, MELANIE ;MORRIS, ALISON  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Biology;Lung;Medicine;Training Programs

PROJECT_TITLE: Translational Training Program in Pulmonary Biology and Medicine

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Arctic;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: ANCHORAGE

ORG_NAME: ALASKA NATIVE TRIBAL HEALTH CONSORTIUM

ORG_STATE: AK

PHR: PROJECT NARRATIVE Alaska Native people have the highest reported colorectal cancer burden in the world, yet only half have been screened for this disease, which could save lives. This multi-level, mixed-methods randomized controlled trial will investigate the effectiveness of a new at-home multi-target stool DNA test (MT-sDNA; Cologuard) to improve colorectal cancer screening rates among Alaska Native people living in rural/remote communities. If use of MT-sDNA increases colorectal cancer screening, it will help reduce Alaska Native deaths due to this disease, have broad-reaching clinical and policy impacts, and provide insight into a novel method that could improve screening among other integrated health systems that provide care to high-risk and underserved populations in the United States and worldwide.

PI_NAMEs: REDWOOD, DIANA  (contact)

PROGRAM_OFFICER_NAME: DORIA-ROSE, PAUL P

PROJECT_TERMS: Address;Adherence;adherence rate;Administrator;Age;Alaska;Alaska Native;Alaska Native population;arm;attributable mortality;Cancer Burden;Cancer Control;Caring;Cessation of life;Clinic Visits;Clinical;clinical practice;Collaborations;Colonoscopy;Colorectal Cancer;colorectal cancer screening;Communities;community based participatory approach;community based participatory research;Community Health Aides;community intervention;community setting;Data;Detection;Diagnostic;Diagnostic Reagent Kits;Diagnostic tests;Disease;DNA;Educational Materials;Effectiveness;effectiveness testing;Eligibility Determination;feasibility testing;Fecal occult blood;Feces;Focus Groups;follow-up;formative assessment;Future;Gastrointestinal Hemorrhage;Geography;Goals;Group Interviews;Guaiac;health belief;health care delivery;health disparity populations;health organization;Health Personnel;Health system;Healthcare;Helicobacter Infections;high risk;Home;implementation strategy;improved;Incidence;Individual;informant;innovation;insight;Integrated Health Care Systems;Intervention;Interview;Leadership;Measures;meetings;Methods;Modeling;Multicultural Education;Navigation System;neoplastic;novel;outreach;Participant;patient navigation;Patients;Policies;Population;Precancerous Polyp;preference;premalignant;Prevention;process evaluation;promoter;protocol development;Provider;Public Health;Quality Control;Randomized, Controlled Trials;recruit;remote communities;Reporting;Research;Research Design;research study;response;Rural;rurality;Sampling;scale up;screening;screening guidelines;sex;social;Subgroup;Surveys;System;system-level barriers;Testing;testing uptake;theories;therapy development;treatment as usual;tribal community;Tribal group;tribal health;tribal healthcare;tribal organization;Underserved Population;United States;uptake;usability;Variant;Work

PROJECT_TITLE: Randomized controlled trial of the stool DNA test to improve colorectal cancer screening among Alaska Native people

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-F(51)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: PISCATAWAY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Alcohol use disorders (AUD) exact a major personal, economical, and societal toll, highlighting the urgent need for developing effective therapeutics. Reciprocal interactions between autonomic arousal and alcohol consumption play a key role in the etiology of AUD, but the underlying neurobiological mechanisms are poorly understood. By establishing how top-down modulation of arousal by the prefrontal cortex affects drinking and how drinking itself modifies top-down control, this proposal will identify novel neural therapeutic targets for treating excessive drinking driven by aberrant arousal.

PI_NAMEs: HUDA, RAFIQ  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acute;Address;Affect;alcohol abuse therapy;alcohol behavior;Alcohol consumption;alcohol seeking behavior;alcohol use disorder;Animal Model;Anterior;Arousal;binge drinking;Calcium;Cells;chronic alcohol ingestion;cingulate cortex;Color;Consumption;D Cells;Darkness;Data;design;Diameter;Disinhibition;drinking;effective therapy;Electrophysiology (science);Ethanol;Etiology;experimental study;Female;Functional disorder;Head;Heavy Drinking;hippocampal pyramidal neuron;Hyperactivity;Image;in vivo;in vivo imaging;inhibitory neuron;Interneurons;Light;Link;machine vision;male;Measurement;Measures;Mediating;Mus;Mydriasis;neural;neurobiological mechanism;neuronal circuitry;Neurons;Neurosecretory Systems;new therapeutic target;novel;optogenetics;Output;Pathway interactions;Patients;Persons;Physiological;Play;pre-clinical;Pre-Clinical Model;Prefrontal Cortex;Prevalence;Property;Pupil;Pyramidal Cells;Recording of previous events;Relapse;response;Role;serial imaging;Sex Differences;Shapes;Slice;Somatostatin;Stimulus;Stress;Sucrose;Synapses;Testing;therapeutic target;therapeutically effective;Time;two-photon;Vasoactive Intestinal Peptide;Work

PROJECT_TITLE: Prefrontal cortical microcircuit mechanisms for reciprocal interactions between arousal and ethanol consumption

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BOSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative: The Bioinformatics and Integrative Genomics doctoral program at Harvard Medical School provides students trained in the quantitative sciences a deep understanding of molecular biology and genetics, a rigorous experience in modern computational approaches for analyzing large datasets, and a rich environment with faculty mentors who are experts in bioinformatics and genomics. This program will continue to produce leaders who are using genomic sciences to advance biomedical research and clinical practice.

PI_NAMEs: PARK, PETER J (contact)

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Bioinformatics;Genomics;Training

PROJECT_TITLE: Training in Bioinformatics and Integrative Genomics


NIH_SPENDING_CATS: Bioengineering;Immunotherapy

ORG_CITY: IRVINE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative This project will enhance our capability to invent therapeutics and subsequently prepare these medicines on large-scale. Inspired by Nature’s catalyst, we develop ideal, environmentally friendly, and powerful ways to transform simple building blocks (aldehydes, alkenes, and alkynes) into architectures relevant to medicine. Our expertise in molecular design and synthesis will also be applied to address challenges at the interface of chemical theory, fluorescent microscopy, and drug discovery.

PI_NAMEs: DONG, VY M (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Address;Aldehydes;Alkenes;Alkynes;Amines;Architecture;Biology;cancer immunotherapy;Carbon;Catalysis;catalyst;chemical synthesis;Chemicals;Cobalt;Copper;Coupling;cyclopropene;design;design and construction;diene;drug discovery;Environment;experimental study;Friends;functional group;innovation;insight;invention;Medicine;Metals;Methods;Microscopy;Modernization;Molecular;Molecular Probes;Nature;Nitrogen;NMR Spectroscopy;Organic Synthesis;Periodicity;Pharmaceutical Chemistry;Research Project Summaries;Rhodium;Science;Styrenes;Theoretical Studies;theories;Therapeutic;tool;Training;Transition Elements;unsaturated bonds

PROJECT_TITLE: Innovative Tools for Chemical Synthesis: Metal-Hydride Catalysis, Medicinal Motifs, and Molecular Probes


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Mental Health;Mental Illness;Prevention;Schizophrenia;Serious Mental Illness;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: TORONTO

ORG_NAME: CENTRE FOR ADDICTION AND MENTAL HEALTH

PHR: Project Narrative Substance use and other psychiatric disorders are highly heritable (i.e., are strongly influenced by genetics) and often occur together. Our project will apply Big Data approaches to develop an analytic pipeline to elucidate the shared genomic liability, biological mechanisms, and potential causal effects underlying concurrent tobacco use and schizophrenia. This pipeline can be expanded to other pairs of concurrent substance use and psychiatric disorders and may lead to novel early intervention and treatment strategies.

PI_NAMEs: CHENOWETH, MEGHAN  (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: addiction;Address;Antipsychotic Agents;Big Data;bioinformatics tool;Biological;Biological Factors;Biological Markers;care costs;Cigarette;Cognitive deficits;Collaborations;comorbidity;Complex;Controlled Study;Cotinine;Data;Data Set;diagnostic criteria;Disease;Drug abuse;Drug Addiction;drug discovery;Early Intervention;economic cost;Environmental Risk Factor;Etiology;European ancestry;experience;Future;Gene Cluster;Genes;Genetic;genetic architecture;Genetic Risk;genetic risk factor;Genetic study;Genetic Transcription;genetic variant;genome wide association study;genome-wide;genomic data;genomic locus;Genomics;Genotype;Grant;Health Care Costs;Hereditary Disease;Heritability;Heterogeneity;hydroxycotinine;improved;Individual;Intake;International;Intervention;Investigation;Maps;Measures;men;Mendelian randomization;Mental disorders;new therapeutic target;Nicotine;nicotine use;Nicotinic Receptors;non-smoker;novel;Pathway interactions;Patient Self-Report;Pharmaceutical Preparations;pleiotropism;Population;Population Heterogeneity;Prevention;programs;Research;Research Design;Research Personnel;risk variant;Sample Size;Schizophrenia;schizophrenia risk;Self Medication;sex;Sex Differences;side effect;Signal Transduction;Smoke;Smoker;Smoking;Smoking Behavior;statistics;Subgroup;substance use;Substance Use Disorder;Testing;theories;Tobacco use;Tobacco Use Disorder;Training;trait;transcriptome;treatment strategy;Woman;women versus men;Work

PROJECT_TITLE: Concurrent substance use and psychiatric disorders: a pipeline to investigate shared genomic liability and causal effects

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Chromatin replication is a complex cellular process that requires multiple regulatory mechanisms to maintain genomic and epigenomic stability. The histone H3.1-TSK/TONSL pathway plays a major role in resolving stalled or broken replication forks via homologous recombination. We will further characterize the role of H3.1- TSK/TONSL in regulating DNA repair and genome stability, and define new functions for this conserved pathway during replication.

PI_NAMEs: JACOB, YANNICK  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Affect;Cell Physiology;Chromatin;Complex;daughter cell;Development;DNA biosynthesis;DNA Methylation;DNA Repair;DNA replication fork;Epigenetic Process;epigenomics;Eukaryota;Genetic;Genetic Transcription;Genome;Genome Stability;Genomics;Goals;Health;Histone H3;histone modification;Histones;homologous recombination;Human;human disease;Information Protection;interest;Maintenance;Malignant Neoplasms;Mediating;Molecular;Mutation;Neurodegenerative Disorders;novel;Organism;Pathway interactions;Play;prevent;Process;Proteins;Research;Role;Tertiary Protein Structure;transmission process;Variant;Work

PROJECT_TITLE: Investigating the roles of the H3.1-TSK/TONSL pathway during chromatin replication

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Dental, Oral, and Craniofacial Disease;Diabetes;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Microbiome

ORG_CITY: NASHVILLE

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: NARRATIVE Periodontitis (PD), an infection of the oral cavity caused by Gram-negative bacteria, is a risk factor for cardiovascular diseases. Endothelial dysfunction is the initial step in the development of cardiovascular diseases. The goal of this project is to elucidate the molecular mechanisms that contribute to the suppression of NO in PD and to delineate their role in the pathogenesis of endothelial dysfunction in diabetic and non-diabetic rodent models.

PI_NAMEs: GANGULA, PANDU R (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Anabolism;Animal Model;antioxidant enzyme;Antioxidants;Aorta;Attenuated;Biological Availability;Blood Vessels;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cell Survival;Chronic;Chronic Disease;cofactor;Collaborations;college;Communicable Diseases;Complex;Coronary heart disease;Cyclic GMP;cytokine;Data;Development;Diabetes Mellitus;diabetic;diabetic patient;Dietary Supplementation;Dimerization;disease model;Early Diagnosis;effective intervention;Endothelial Cells;endothelial dysfunction;enzyme activity;enzyme biosynthesis;Enzymes;Erythroid;Event;Exhibits;experience;Female;Forsythia;Fusobacterium nucleatum;Goals;Gram-Negative Bacteria;Human;Hyperglycemia;Hypertension;Immune signaling;Impairment;improved;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Laboratories;male;Measures;Mediating;Modeling;Molecular;Mus;Muscle relaxation phase;Myocardial Infarction;Nitric Oxide;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;NOS3 gene;novel;Nuclear;Oral cavity;oral infection;oral microbial community;oxidation;Oxidative Stress;pathogen;Pathogenesis;Pathology;Pathway interactions;Periodontal Diseases;Periodontal Infection;Periodontitis;periodontopathogen;Persons;Play;Porphyromonas gingivalis;protein expression;Protein Kinase;Publications;Reactive Oxygen Species;Relaxation;Reporting;Research;Research Personnel;Resistance;Risk;Rodent;Rodent Model;Role;sepiapterin;Signal Transduction;Soluble Guanylate Cyclase;Stroke;Supplementation;Testing;tetrahydrobiopterin;Texas;Time;Treponema denticola;Vascular Diseases;vascular endothelial dysfunction;Vascular Endothelium;Vascular Smooth Muscle

PROJECT_TITLE: Role of Oral Microbiota on Vascular Function


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Lung;Pulmonary Hypertension

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: This study will enroll patients diagnosed with pulmonary embolism (blood clots in the lung) in the emergency department and treat them with either supplemental oxygen or normal room air. The purpose of the study is to determine how supplemental oxygen affects the pulmonary artery, right ventricle, and metabolic processes in patients with these blood clots. We will also perform experiments in pigs with pulmonary emboli to determine how treatment with supplemental oxygen affects the flow of blood through the lungs and cardiac metabolism.

PI_NAMEs: KABRHEL, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Affect;Air;American;Angiography;Biometry;Blinded;Blood;Blood coagulation;Blood flow;Blood specimen;Branched-Chain Amino Acids;Breathing;Cardiac Output;Cardiology;Cardiopulmonary;Cardiovascular system;Carnitine;Categories;Catheters;Cessation of life;Chest;Citric Acid Cycle;Clinical;Clinical Trials;Collaborations;Correlation Studies;Cross-Over Trials;Data;Denmark;design;Diagnosis;Diglycerides;Dilatation - action;Echocardiography;Embolism;Emergency Department patient;Enrollment;Etiology;experience;Experimental Designs;Experimental Models;experimental study;face mask;Failure;Family suidae;Fellowship;Financial cost;Future;General Hospitals;Heart;heart metabolism;Human;human subject;Hypoxemia;Hypoxia;Image;improved;Incidence;innovation;Knowledge;Label;Left ventricular structure;Lung;lung hypoxia;Magnetic Resonance Imaging;Massachusetts;Measurement;Measures;Mechanics;medical schools;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methodology;Molecular;mortality;multimodality;Myocardial;Myocardial perfusion;Obstruction;Oxygen;participant enrollment;Pathogenicity;Patients;Perfusion;phrases;Physiology;Plasmalogens;porcine model;Positioning Attribute;pre-clinical;Process;Public Health;Publishing;pulmonary arterial pressure;Pulmonary artery structure;Pulmonary Embolism;Pulmonary Hypertension;pulmonary vasoconstriction;Pyruvate;Randomized;Recording of previous events;recruit;Regulation;Reproducibility;Research;Research Design;Research Personnel;Right Ventricular Dysfunction;Right ventricular structure;Risk;Series;Shock;Societies;supplemental oxygen;Syndrome;Testing;therapeutic target;Thrombus;Time;Tissues;Training;Triglycerides;United States;Universities;Up-Regulation;vasoconstriction;Ventricular septum;Work;X-Ray Computed Tomography

PROJECT_TITLE: Supplemental Oxygen for Pulmonary Embolism (SO-PE) - A Mechanistic Clinical Trial

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Comparative Effectiveness Research;Data Science;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative  The methods and software developed from our research can be widely applied in various medical and epidemi- ological studies to increase the transparency, validity, and accuracy of treatment effect estimation, by reducing the bias and variation associated with ad hoc model building or over-optimistic machine learning. As such, our research will be instrumental in providing patients, clinicians, and other healthcare stakeholders with the infor- mation needed to make better informed healthcare decisions and improve healthcare delivery and outcomes.

PI_NAMEs: TAN, ZHIQIANG  (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: Anticoagulants;Applied Research;Atrial Fibrillation;Atrial Flutter;Calibration;care outcomes;Collaborations;Comparative Effectiveness Research;comparative effectiveness study;comparative treatment;Complex;complex data;computing resources;Confounding Factors (Epidemiology);Data;data resource;design;Dipeptidyl Peptidases;Documentation;Drug Prescriptions;Effectiveness;epidemiology study;Grant;hazard;Health;health care delivery;Healthcare;high dimensionality;improved;inhibitor;instrument;Machine Learning;machine learning method;Measures;Medical;Medicare;Medicine;Methods;model building;Modeling;multidimensional data;Non-Insulin-Dependent Diabetes Mellitus;novel;Observational Study;Oral;Outcome;Patients;Pharmaceutical Preparations;Population;Predisposition;Probability;Process;Property;random forest;Research;Research Personnel;Resort;Risk Factors;Safety;safety study;Schedule;Schizophrenia;software development;Statistical Data Interpretation;statistical learning;Statistical Methods;Statistical Models;statistics;Therapeutic;treatment effect;treatment group;treatment strategy;Uncertainty;user friendly software;Variant;Work

PROJECT_TITLE: Novel and Rigorous Statistical Learning and Inference for Comparative Effectiveness Research with Complex Data

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Rare Diseases;Uterine Cancer;Women's Health Research

PHR: Project Narrative: Uterine serous carcinomas (USC) are the most aggressive subtype of uterine cancers, yet the molecular drivers of disease spread remains incompletely understood. Previous work by our group and others have identified a recurrent mutational hotspot within the gene encoding for the scaffolding subunit of the protein phosphatase 2A (PP2A), PPP2R1A, that occur almost exclusively within the USC subtype of uterine cancer. These hotspot mutations may contribute to uterine tumorigenesis by inactivating tumor suppressive PP2A function by specifically altering holoenzyme biogenesis thereby inducing dysregulation upon WNT mediated EMT while enhancing tumorigenicity in a manner that promotes USC disease progression.

PI_NAMEs: HAANEN, TERRANCE JAMES (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: 3-Dimensional;beta catenin;Biogenesis;cancer cell;Cancer Cell Growth;Cancer cell line;cancer type;Carcinoma;Cell Line;Cell secretion;Cells;Cessation of life;Communication;Complement;Complex;Coupled;CRISPR/Cas technology;Data;Development;Diagnosis;Disease;Disease Progression;disorder subtype;Distant;Dominant-Negative Mutation;Dose Limiting;effective therapy;Endometrial;enhancing factor;Family;gain of function;Genes;Genetic Transcription;Greater sac of peritoneum;Heterozygote;Holoenzymes;Immunocompromised Host;Impairment;In Vitro;in vivo;Injections;intraperitoneal;Invaded;Investigation;Knock-in;leiomyosarcoma;Ligands;Link;Luciferases;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Modeling;Molecular;Mus;mutant;Mutation;Nature;Neoplasm Metastasis;neoplastic cell;neutralizing antibody;new therapeutic target;Nodule;notch protein;overexpression;Pathway interactions;Patients;permissiveness;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Process;Protein phosphatase;Protein Subunits;Proteins;Recurrence;Regulation;Role;scaffold;Serine;Serous;Signal Pathway;Signal Transduction;Site;small hairpin RNA;Testing;Threonine;Transfection;Transforming Growth Factor beta;tumor;tumor initiation;tumor microenvironment;Tumor Promotion;Tumor Subtype;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;Tumorigenicity;United States;Uterine Cancer;Uterine Corpus Carcinosarcoma;Uterine Neoplasms;Uterus;WNT Signaling Pathway;Work;Xenograft Model

PROJECT_TITLE: Deciphering the functional role of recurrent PPP2R1A mutations on endometrial metastasis


NIH_SPENDING_CATS: Genetics

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Maternal proteins passed from a mother to her progeny can have a profound impact on animal development and immunity. The goals outlined in this project utilize a molecular biology labeling method to elucidate new, fundamental insights into how maternally made proteins are inherited by progeny. Ultimately, the work provides a foundation to determine the breadth of non-genetic maternal information a mother provides her offspring.

PI_NAMEs: AOKI, SCOTT T (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Affect;Animals;Biochemistry;Caenorhabditis elegans;Cell Culture Techniques;Cells;chromatin remodeling;Cytoplasmic Granules;Development;DNA;DNA Modification Process;Enzymes;Family;Foundations;Future Generations;Gene Expression Regulation;gene-editing approach;Generations;Germ Cells;Germ Lines;Goals;Histones;imaging capabilities;Immunity;In Situ;in vivo;Inherited;insight;interest;Label;Ligand Binding;Methods;model organism;Molecular;Molecular Biology;Mothers;Mus;Nematoda;non-genetic;novel;Nutrient;offspring;Organism;Parents;Physical condensation;Physiologic pulse;protein complex;Proteins;RNA;RNA-Binding Proteins;Testing;Time;Tissues;transmission process;tumor;Visualization;Work

PROJECT_TITLE: Biochemistry in situ to determine inheritance of RNA-protein complexes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: MH

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PHR: Project Narrative: The research outlined in this proposal meets an ongoing need to enhance services for autistic transition-age youth. The project will evaluate the effectiveness of Virtual Interview Training for Transition Age Youth (VIT) at enhancing employment and mental health outcomes for autistic transition-age youth engaged in school- based pre-employment transition services (ETS), while simultaneously evaluating initial implementation processes associated with optimizing VIT delivery and engagement within the context of ETS.

PI_NAMEs: SMITH, MATTHEW JAMES (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: active control;Address;adolescent with autism spectrum disorder;adult with autism spectrum disorder;Age;Anxiety;autism community;autism spectrum disorder;autism symptoms;autistic;Behavior;budget impact;Career Choice;career preparation;college;cost effective;cost effectiveness;Disparity;E-learning;Education;Effectiveness;effectiveness evaluation;effectiveness/implementation hybrid;Employment;Enrollment;Evaluation;Evidence based practice;experience;Face;Feedback;Focus Groups;follow-up;Future;future implementation;Goals;Grant;Health Services Research;high school;Hour;hybrid type 1 trial;hybrid type 2 trial;Hybrids;implementation cost;implementation efforts;implementation evaluation;implementation outcomes;implementation process;implementation strategy;implementation/effectiveness;improved;improved outcome;innovation;internet delivery;Intervention;Interview;Job Application;Measures;Mediating;Mediation;Mental Depression;Mental Health;Methods;Motivation;National Institute of Mental Health;Occupations;Outcome;Persons;Pilot Projects;Play;Preparation;process evaluation;psychological distress;Race;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Rehabilitation therapy;Research;Resources;Role;scaffold;Schools;Series;Services;Site;skills;social skills;Special Education;Strategic Planning;Surveys;System;teacher;Teacher Professional Development;Technology;Testing;Time;Token Economy;Training;Unemployment;usability;Validation;Variant;virtual;virtual reality;Voice;Wages;Work;Youth

PROJECT_TITLE: A Hybrid Effectiveness-Implementation RCT of Virtual Interview Training for Autistic Transition-Age Youth

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Pain Research;Substance Misuse

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: More than 70 million Americans live with pain, but current painkillers work only in a fraction of patients and cause an array of side effects that include the risk of developing addiction. Recent work suggests that an enzyme called N-acylethanolamine acid amidase (NAAA) is critically involved in pain processing and may be targeted to discover non-addictive medicines to treat acute and chronic pain. Here, we propose a series of experiments aimed at testing this hypothesis and at developing NAAA inhibitors as a novel class of safe and effective painkillers.

PI_NAMEs: PIOMELLI, DANIELE  (contact)

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: abuse liability;Acids;Acute;Acute Pain;addiction;Address;Agonist;American;amidase;Analgesics;Animals;antinociception;Attenuated;Behavior;Brain;cannabinoid receptor;Cell Lineage;cell type;Cells;Chemicals;chronic constriction injury;chronic pain;Collaborations;Compensation;conditioned place preference;constriction;Cysteine;Data;design;Development;Dose;Dose Limiting;drug discovery;Endocannabinoids;Enzymes;Exhibits;experimental study;FAAH inhibitor;Formalin;Helping to End Addiction Long-term;Hydrolase;improved;inhibitor;Injections;Injury;innovation;International;Intravenous;Knockout Mice;Ligands;Lipids;Literature;Mediating;Medicine;Meta-Analysis;Modeling;Molecular Target;monocyte;Motivation;Mus;nerve injury;Neurons;Neuropathy;Nociception;novel;Nuclear Receptors;Opioid;overexpression;Pain;Pain management;pain processing;palmidrol;Pathologic;Patients;Penetration;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phenocopy;Population;Positioning Attribute;PPAR alpha;pre-clinical;preclinical study;Property;Public Health;Publishing;Regulation;Research;Resolution;response;Rewards;Risk;Role;sciatic nerve injury;Self Administration;Sensory;Series;side effect;Signal Transduction;Spinal Cord;Spinal Ganglia;Structure;Structure-Activity Relationship;Testing;Therapeutic;Therapeutic Effect;tool;transcription factor;United States National Institutes of Health;Wild Type Mouse;Work

PROJECT_TITLE: The lipid hydrolase NAAA as a target for non-addictive analgesic medications