NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: Los Angeles

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Current neuro-protective and neuro-regenerative strategies to restore vision to the over 64 million people worldwide who are legally blind from diseases that damage the optic nerve are successful at promoting survival of damaged retinal ganglion cells (RGCs) and promoting long distance RGC axon regeneration but are lacking in cues to guide axons towards appropriate targets in the brain. We have shown that exogenously applied electric fields (EFs) not only promote RGC axon growth but appear to also be able to control the direction of axon growth. In this project, we propose to develop EF application into a technology that will synergize that with current strategies for optic nerve regeneration by providing directional cues for regenerating axons, leading to more targeted growth and increased recovery of visual function.

PI_NAMEs: GOKOFFSKI, KIMBERLY K (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: 3-Dimensional;Adult;Anatomy;Animals;Axon;axon growth;axon regeneration;Back;Behavioral;Blinded;Brain;brain control;Brain-Derived Neurotrophic Factor;Calcium;Cell Survival;Cells;Ciliary Neurotrophic Factor;CISH gene;combinatorial;Combined Modality Therapy;Crush Injury;Cues;Cyclic AMP;Data;deep learning algorithm;Development;Disease;efficacy testing;electric field;Electrical Engineering;Electron Microscopy;Electrophysiology (science);Electroretinography;Exhibits;experience;experimental study;Eye;Fluorescence Microscopy;FRAP1 gene;Growth;Histology;Image;in vivo;Individual;Knock-out;Knockout Mice;Label;Legal Blindness;legally blind;Length;Light;Maps;Mediating;microscopic imaging;Microscopy;Morphology;multi-electrode arrays;multidisciplinary;Mus;myelination;Natural regeneration;Nerve Regeneration;Neurons;neuroprotection;Neurosurgeon;Ophthalmologist;Optic Nerve;optic nerve disorder;optic nerve regeneration;Optic Nerve Transections;overexpression;Patients;Pattern;Perimetry;Persons;premature;prevent;PTEN gene;Ras homolog enriched in brain;Rattus;Recovery;regenerative;Reporting;Resolution;response;restoration;Retina;retinal damage;retinal ganglion cell degeneration;retinal ganglion cell regeneration;Retinal Ganglion Cells;retinal regeneration;sight restoration;Signal Transduction;superior colliculus Corpora quadrigemina;Synapses;synaptogenesis;synergism;Technology;Testing;Tissues;Viral Vector;Vision;Visual;Zymosan

PROJECT_TITLE: Morphologic and Functional Assessment of Field-Potentiated Optic Nerve Regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (02)]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Digestive Diseases;Microbiome;Neurosciences;Nutrition;Physical Activity;Prevention

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE Exercise is an extremely efficient lifestyle factor to prevent and reverse metabolic, inflammatory, and neoplastic diseases, but exercise is hard and the regulatory mechanisms driving an individual's ability to exercise remain poorly understood. This proposal explores the impact of the intestinal microbiota on the activity of brain neurons that influence exercise performance. The results of these experiments will enhance our understanding of how exercise performance can be controlled, and possibly enhanced, from the gastrointestinal tract.

PI_NAMEs: BETLEY, JOHN NICHOLAS;THAISS, CHRISTOPH ALEXANDER (contact)

PROGRAM_OFFICER_NAME: KOEMETER-COX, ANDREW IAN

PROJECT_TERMS: Address;Afferent Neurons;Amides;Animals;Automobile Driving;Behavior;Behavioral;Brain;brain control;brain pathway;Cardiovascular Diseases;cardiovascular risk factor;Cells;Chronic Disease;CNR1 gene;collaborative approach;commensal microbes;Communication;Corpus striatum structure;Data;Development;Diabetes Mellitus;Diet;dietary;Dietary Intervention;Disease;Dopamine;Dopamine D1 Receptor;Elements;Endocannabinoids;Exercise;Exercise Physiology;experimental study;Fatty Acids;Future;gastrointestinal;Gastrointestinal tract structure;Gene Cluster;Gene Expression;General Population;Genes;Genetic;Germ-Free;Gnotobiotic;Goals;gut microbiome;gut microbiota;gut-brain axis;Habits;Health Benefit;host microbiome;Human;Immediate-Early Genes;improved;Individual;Inflammatory;innovation;insight;Intervention;Intestines;Investigation;lens;Life Style;lifestyle factors;lifestyle intervention;Link;Literature;Malignant Neoplasms;Measurement;Measures;Mediating;member;Metabolic;microbial;microbial colonization;microbiome;microbiome research;microbiota;Modernization;Molecular;Monitor;Motivation;Mus;neoplastic;Nerve Degeneration;neural;Neurodegenerative Disorders;Neurons;neurophysiology;Neurosciences;neurotransmission;novel strategies;Operative Surgical Procedures;Output;Performance;Peripheral;pharmacologic;Physical activity;Population;pre-clinical;prevent;Psychological reinforcement;Publishing;rational design;Regulation;Research;response;Rewards;Role;sedentary;Sensory;Signal Transduction;Taxonomy;Testing;Therapeutic;tool;TRPV1 gene;willingness;Work

PROJECT_TITLE: Intestinal regulation of exercise performance

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Data Science;Lung;Pediatric;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE - RELEVANCE TO DISEASE Cystic Fibrosis (CF), one of the most common lethal genetic diseases in the United States, is characterized by progressive lung destruction and development of comorbidities as patients age. In 2010, Emory University established a highly successful CF biospecimen repository, and in 2020 Emory and Augusta University established the Georgia CF Data Warehouse (GACFDW), a cloud-based high-quality computational infrastructure that would support access to integrated clinical and research data focusing on non-pulmonary complications in a small cohort of CF patients. The goal of the present proposal is to extend the GACFDW to all 900 CF patients followed at Emory and Augusta CF clinics, to focus on pulmonary complications of CF, and to develop the GACFDW into a unique Data Resource that will strengthen CF researchers’ ability to integrate multiple research data streams with patient clinical status, providing new opportunities to understand factors contributing to disease progression and response to therapy. .

PI_NAMEs: KAMALESWARAN, RISHIKESAN ;MCCARTY, NAEL A;STECENKO, ARLENE A (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Accreditation;Address;Age;aged;American;Animal Model;Architecture;Award;biobank;Biological Specimen Banks;Biomedical Research;Body System;Caring;Caucasians;Center Core Grants;Cessation of life;Child;Clinic;Clinical;Clinical Data;clinical database;cloud based;cohort;comorbidity;computer infrastructure;Cystic Fibrosis;cystic fibrosis patients;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Data Analyses;data preservation;data resource;data sharing;data streams;data warehouse;design;Development;Diagnosis;Disease;Disease Progression;Ecosystem;Elderly;Ethics;Event;experience;Faculty;follow-up;Foundations;Functional disorder;Genes;Genetic Diseases;Goals;Grant;Health;Healthcare;Hereditary Disease;Human;human disease;human subject;improved;Individual;infancy;Institution;Investigation;Ion Channel;Life;Link;Longevity;Longitudinal cohort;Longitudinal Studies;Lung;Lung Diseases;Maintenance Therapy;Malnutrition;Mission;Modernization;Morbidity - disease rate;mortality;Mutation;National Heart, Lung, and Blood Institute;Neonatal Screening;Newborn Infant;Outcome;Patients;Persons;Pharmaceutical Preparations;Pilot Projects;Pneumonia;preservation;privacy preservation;Pulmonary Cystic Fibrosis;recruit;Research;Research Personnel;Research Support;Resources;response;Running;Sampling;Scientist;Specimen;Supportive care;survival prediction;Technology;Therapeutic;Time;Training;translational scientist;Translations;treatment response;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: The Georgia Cystic Fibrosis Data Warehouse

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-T (55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cystic Fibrosis;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Palliative Care;Rare Diseases;Social Determinants of Health

ORG_DEPT: FAMILY MEDICINE

PHR: Project Narrative People with cystic fibrosis (CF) are living longer with new treatments, but symptoms like pain, cough, and tiredness continue to affect their quality of life. This study will look at symptoms that occur together, and relationships between symptoms and individuals’ biological processes, social environment, and the care they receive. The goal is to identify new opportunities to reduce symptom burden for people with CF.

PI_NAMEs: KAVALIERATOS, DIONYSIOS  (contact)

PROJECT_TERMS: Adult;Affect;associated symptom;Asthma;Biological;Biological Factors;Biological Process;biopsychosocial;Body System;burden of illness;Caring;Chronic Obstructive Pulmonary Disease;Client satisfaction;Clinical;clinical care;clinically relevant;Cohort Studies;contextual factors;Coughing;Cystic Fibrosis;Data;demographics;Disease;Dyspnea;Effectiveness;emotional symptom;Enrollment;Etiology;Exhalation;Exhibits;experience;Fatigue;Goals;Grouping;Healthcare;Heart failure;Impairment;improved;improved outcome;Individual;Inflammation;Inflammatory;Intervention;Interview;Life Expectancy;Link;Managed Care;Mental Depression;Metabolic;Metabolic Pathway;metabolomics;Methods;Molecular;mortality;multi-site trial;novel;Observational Study;Organ;Outcomes Research;Oxidative Stress;Pain;Palliative Care;Pathogenesis;patient oriented;Patient Outcomes Assessments;Patients;Pattern;person centered;Persons;Phenotype;Physical condensation;physical symptom;Plasma;Poverty;prevent;Quality of life;Race;reduce symptoms;Reporting;Research;respiratory;Sampling;Severities;Site;social;Social Environment;social factors;social health determinants;social influence;Surveys;Symptom Burden;symptom cluster;symptom management;symptom science;Symptoms;System;Techniques;Therapeutic;Therapeutic Intervention;Therapeutic Research;Work

PROJECT_TITLE: Advancing Symptom Science and Management in Cystic Fibrosis: Biological, Social, and Clinical Mechanisms

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Nanotechnology;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This proposed study aims to develop a new long-acting injectable (LAI) delivery system that provides tunable and sustained release of protein therapeutics, insulin-like growth factor-1 and agrin, to enable persistent regeneration of injured peripheral nerves. This translation-driven study will demonstrate functional efficacy of the optimized LAI delivery system on PNI repair in rat and NHP models.

PI_NAMEs: MAO, HAI-QUAN  (contact);TUFFAHA, SAMI

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Address;Affect;Agrin;Anatomy;Apoptotic;Artificial nanoparticles;Atrophic;Axon;axon regeneration;Biodistribution;biomaterial compatibility;caprolactone;cell type;Chronic;Clinical;clinical application;clinical translation;Clinical Treatment;clinically relevant;Complement;Complex;Denervation;design;Development;disease model;Distal;Dose;Effectiveness;efficacy evaluation;efficacy testing;Encapsulated;Engineering;ethylene glycol;Formulation;Functional Regeneration;Glycoproteins;Growth Factor;Half-Life;Histologic;Hyaluronic Acid;Hydrogels;improved;in vivo;Injectable;Injections;injury and repair;injury recovery;Insulin-Like Growth Factor I;Kinetics;Maintenance;manufacture;Measurement;Measures;Methods;Modeling;Motor;Motor Endplate;Muscle;Muscle Cells;muscle reinnervation;Muscular Atrophy;nanoparticle;nanopolymer;Natural regeneration;Nerve;nerve injury;Nerve Tissue;Neuromuscular Junction;Neurons;nonhuman primate;novel;particle;Patients;Peripheral nerve injury;peripheral nerve repair;Pilot Projects;pre-clinical;Preparation;preservation;Proteins;prototype;Rattus;Recovery of Function;regenerative;reinnervation;Risk;Safety;Schwann Cells;Self Administration;Site;Somatotropin;System;systemic toxicity;Therapeutic;therapeutic protein;therapy outcome;Tissues;translational potential;Translations;Treatment Efficacy;treatment strategy

PROJECT_TITLE: Long-acting Injectable Protein Delivery System for Functional Repair of Peripheral Nerve Injury

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Wound Healing and Care

ORG_DEPT: PATHOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: A major undesirable outcome of cataract surgery wounding is the development of the lens fibrotic disease, Posterior Capsule Opacification (PCO). The proposed studies take important steps toward elucidating how extracellular cell-surface vimentin functions to promote a fibrotic response to lens injury. Findings from these studies are expected to inform new treatment strategies for PCO, with potential application to understanding how extracellular vimentin mediates fibrotic disease and pathogenesis in other tissue types.

PI_NAMEs: JANMEY, PAUL A;TAIYAB, AFTAB ;WALKER, JANICE LYNN (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Address;Adopted;Antibodies;Automobile Driving;Binding;Biochemical;capsule;Cataract Extraction;Cell Separation;Cell surface;Cells;Characteristics;Chickens;Complex;cytokine;Cytoskeletal Filaments;Data;Disease;Environment;Enzymes;extracellular;Extracellular Matrix;Extracellular Space;Fibrosis;Foundations;Genetic;Glycocalyx;Glycosaminoglycans;Goals;Inflammatory;Injury;innovation;insight;Intermediate Filaments;Knowledge;lens;Lens development;Link;Literature;Location;Mediating;Modeling;Modification;Molecular;Mus;Mutant Strains Mice;Myofibroblast;Nature;novel;novel therapeutic intervention;Outcome;Oxidative Stress;Pathogenesis;Pathogenicity;Pathologic;Pathologic Processes;Pathway interactions;Phosphorylation;Physiological Processes;polyacrylamide gels;Population;Post-Translational Protein Processing;prevent;Process;Property;Protein Glycosylation;Protein-arginine deiminase;Regulation;Research;response;response to injury;Role;sensor;Shapes;Signal Transduction;stem cells;Stress;Structure;Surgical Models;Surgical wound;targeted treatment;Techniques;Testing;Time;Tissues;tool;Transforming Growth Factor beta;treatment strategy;Vimentin;Work;wound;wound healing

PROJECT_TITLE: Molecular function of extracellular vimentin in regulating the response to lens wounding

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: Sodium plays a critical role that influences almost every biological process in humans. Recent studies have highlighted the potential role of novel salt storage ability in the body. However considerable debate continues as to the location and even existence of these storage systems. The current study seeks to definitively establish the existence and location of these candidate sodium storage systems.

PI_NAMEs: TESTANI, JEFFREY M (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TITLE: Exploring water free sodium storage

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Heart Disease;Lung;Physical Activity;Pulmonary Hypertension

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative The goal of this proposal is to characterize the pathophysiologic response to exercise in chronic severe pulmonary hypertension and right ventricular failure (PH-RVF) and then use this novel physiologic understanding to develop a more durable, wearable mechanical cardiopulmonary support system – pulmonary assist device (PAD) - for patients with chronic severe PH-RVF. Our multidisciplinary team will utilize our high- fidelity sheep model of PH-RVF as a platform to first study changes in exercise tolerance and capacity using a treadmill, after which we will then attach the PAD and study any improvements in exercise tolerance. This project will fill the current gap in our understanding about exercise physiology and cardiopulmonary deficit during PH-RVF and how this deficit can be addressed with a wearable mechanical cardiopulmonary support.

PI_NAMEs: BACCHETTA, MATTHEW DOMINIC (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Acute;Address;Animal Model;Animals;Aorta;biomaterial compatibility;Blood;Blood flow;blood pump;Body System;Cardiopulmonary;Cardiovascular system;Caring;Chronic;Clinical;Coupled;design;Destinations;Deterioration;Development;Devices;Disease;Disease Progression;Ensure;Ethics;Etiology;Exercise;exercise capacity;exercise intolerance;Exercise Physiology;Exercise Test;Exercise Tolerance;experimental study;Extracorporeal Membrane Oxygenation;Face;Failure;Fatigue;Functional disorder;Gases;Goals;Heart;Heart Atrium;hemodynamics;Hemolysis;high risk;improved;innovation;Intervention;Investigation;Knowledge;Left;Left atrial structure;Life;Long-Term Effects;Lung;Lung Transplantation;Manuscripts;Mechanics;Medical;Membrane Oxygenators;Metabolic;Metabolism;Modeling;Molecular Profiling;mortality risk;multidisciplinary;novel;operation;Operative Surgical Procedures;Organ;Outcome;Oxygenators;patient mobility;Patient observation;Patients;Perfusion;Phenotype;physiologic stressor;Physiological;Physiology;portability;pressure;prevent;Prognosis;Protocols documentation;Publishing;pulmonary arterial pressure;Pulmonary artery structure;Pulmonary Hypertension;Pulmonary Vascular Resistance;Pump;Quality of life;Recovery;Research;Resistance;Respiration Disorders;respiratory;Respiratory Tract Infections;response;Rest;restoration;Right atrial structure;right ventricular failure;Risk;Self-Help Devices;Sheep;sheep model;Side;Speed;Stress;stress state;stressor;Structure;Support System;Survival Rate;Symptoms;System;Techniques;Technology;Time;Titrations;Transplantation;treadmill;ventricular assist device;Wait Time;wearable device;Work

PROJECT_TITLE: The Road to Destination Therapy: Developing a Durable Ambulatory Mechanical Cardiopulmonary Support for Pulmonary Hypertension

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Lung

ORG_CITY: TYLER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH CTR AT TYLER

ORG_STATE: TX

PHR: Pleural fibrosis is thickening/stiffening of the pleura resulting from pleural infection, asbestos-related pleural disease, and treatments, etc., which leads to severe restrictive lung disease and clinically significant dyspnea associated with fibrothorax. We have identified a gene called Dedicator of Cytokinesis 2 (DOCK2) that plays a key role in mesothelial to mesenchymal transition and pleural fibrosis. The proposed studies will shed new lights on the pathogenesis of pleural fibrosis and may ultimately lead to the identification of novel targets for therapeutic intervention of this detrimental disease.

PI_NAMEs: QIAN, GUOQING  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Actins;Adipose tissue;Asbestos;Attenuated;Bleomycin;Blood Coagulation Factor;calretinin;Carbon Black;cell motility;cell type;Cells;Cerebral Decortication;Chest;Cicatrix;Clinical;clinically significant;Collagen;cytokine;Cytokinesis;Cytoskeletal Modeling;Data;Development;Diet;Disease;Disease Progression;Dyspnea;effusion;Empyema;epithelial to mesenchymal transition;Epithelium;Event;F-Actin;Fatty acid glycerol esters;Fibronectins;Fibrosis;Fructose;Functional disorder;Genes;glycogen synthase kinase 3 beta;Goals;Guanine Nucleotide Exchange Factors;Hematopoietic;Human;Impairment;in vivo;Infection;Inflammatory;injury and repair;Intervention;Invaded;irradiation;knock-down;Knock-out;Knockout Mice;Knowledge;Lung Diseases;Mediating;Mediator;Mesenchymal;Mesothelial Cell;Mesothelium;Metabolic Diseases;migration;Modeling;Molecular;Morbidity - disease rate;Morphology;new therapeutic target;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Pathogenesis;Pathologic Processes;Pathway interactions;Patients;Pharmacological Treatment;Pharmacotherapy;Phosphorylation;Physiological;Plasmin;Play;Pleura;Pleural;Pleural Diseases;Pleural Mesothelial Cell;Pleurisy;Pneumonia;Pre-Clinical Model;prevent;Process;Proliferating;Public Health;Publications;Pulmonary Fibrosis;pulmonary function;Pulmonary Inflammation;Refractory;repaired;Research;Role;Signal Pathway;Signal Transduction;slug;Smooth Muscle;Smooth Muscle Myocytes;Snails;Streptococcus pneumoniae;systemic inflammatory response;Testing;Therapeutic;Therapeutic Intervention;Thrombin;transcription factor;Transforming Growth Factor beta;Tuberculosis;Up-Regulation;Urokinase;Vascular remodeling

PROJECT_TITLE: D0CK2 in pleural fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-E (03)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HOUSTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE This R01 project will address the synergy between Hippo/Yap and Wnt/b-catenin signaling in cardiomyocyte proliferation in adult mice and in human induced pluripotent stem cell-derived cardiomyocytes. Myocardial infarction (MI) is a leading cause of morbidity and mortality world-wide, and patients with MI often progress to chronic heart failure, requiring heart transplantation or mechanical support devices to maintain survival. By leveraging the synergy between Yap and Wnt signaling to induce MI border zone-specific proliferation of cardiomyocytes, this project seeks to understand the mechanistic basis of cardiomyocyte proliferation in the setting of myocardial injury to enable the development of future MI therapies.

PI_NAMEs: MARTIN, JAMES F (contact);WU, SEAN M

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Accounting;Address;Adult;Agrin;Alleles;beta catenin;Cardiac Myocytes;cardiac regeneration;cardiogenesis;cdc Genes;Cell Cycle;Cells;Chromatin;Congestive Heart Failure;Cytoskeletal Modeling;Cytoskeleton;Data;Developing Countries;Development;Devices;disease model;Enhancers;experimental study;Extracellular Matrix;Family suidae;Fetal Heart;Future;gain of function;Gene Expression;Genes;Genetic Transcription;Growth Factor;Health Expenditures;Heart;heart damage;Heart failure;Heart Transplantation;human induced pluripotent stem cells;improved;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Infarction;inhibitor;Intervention;knock-down;Mechanics;Mediating;member;Morbidity - disease rate;mortality;Mus;Myocardial Infarction;myocardial injury;N-Cadherin;Pathway interactions;Patients;Pharmacological Treatment;pre-clinical;Prevalence;Proliferating;Proteins;Publishing;Recombinants;restraint;Role;Sarcomeres;Signal Transduction;small molecule;Societies;Source;Stem cell transplant;Stress;Structure;synergism;Tissue Engineering;Transgenes;WNT Signaling Pathway

PROJECT_TITLE: Reawakening cardiomyocyte proliferation from structural mediated quiescence

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Behavioral and Social Science;Brain Disorders;Clinical Research;Complementary and Integrative Health;Disability Research;Multiple Sclerosis;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Biological age reflects not only chronological age but also the impact of genetics and the environment on the aging process of the brain and body; dietary habits have been shown to have significant effects in studies of general health. In this proposal we will evaluate relationships between diet, biological aging, and neurodegeneration and disease progression in multiple sclerosis (MS). This study will further our understanding of mechanisms of neurodegeneration and neuroprotection in MS, and will help us learn about how diet and other lifestyle factors can impact MS prognosis over time.

PI_NAMEs: KATZ SAND, ILANA BETH (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Age;aging process;biological age;Biological Aging;Brain;brain volume;Caring;cerebral atrophy;Chronology;Clinical;Clinical Trials;cohort;Coupled;Data;Data Collection;Data Set;demographics;design;Diet;Diet Habits;dietary;dietary adherence;Dietary Practices;disability;Disease;Disease Progression;disorder risk;Enrollment;Environment;evidence based guidelines;follow-up;functional decline;Functional disorder;functional outcomes;Funding;Genetic;Health;Health behavior;holistic approach;Image;indexing;Individual;Inflammatory;interest;Intervention;Knowledge;Lead;Learning;Length;Lesion;Leukocytes;Life Style;Life Style Modification;lifestyle factors;lifestyle intervention;Link;Literature;Longitudinal cohort;Longitudinal Studies;Measures;Mediating;Mediator;Mediterranean Diet;Modernization;modifiable risk;Multiple Sclerosis;multiple sclerosis patient;National Health and Nutrition Examination Survey;Nerve Degeneration;Netherlands;neuroprotection;Older Population;Participant;Persons;Phenotype;Population;prevent;Prognosis;protective effect;protective factors;Recommendation;Research;Risk Factors;sample collection;Sampling;secondary analysis;Specimen;telomere;Thalamic structure;Time;United States National Institutes of Health;Validation

PROJECT_TITLE: Mediterranean Diet, Biological Aging, and Risk for Disease and Disability Progression in Multiple Sclerosis

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: Project narrative The goal of this project is to develop tool compounds for studying a protein called the MAS1 receptor, which plays a role in various brain related processes. We have identified early lead compounds that are activators of this protein and will improve and test these compounds using scientific approaches.

PI_NAMEs: MAITRA, RANGAN  (contact);RUNYON, SCOTT P

PROGRAM_OFFICER_NAME: MICHELOTTI, ENRIQUE

PROJECT_TERMS: abuse liability;Affect;Agonist;analog;Angiotensin Receptor;Angiotensins;Animals;anxious;Aversive Stimulus;Behavior;Behavioral;Benzodiazepines;Biological Assay;Brain;Brain region;Calcium;Cardiovascular system;Catalogs;Central Nervous System;Chemicals;Classification;dentate gyrus;design;Development;Disease;Docking;Drug Design;Drug Kinetics;Early identification;efficacy testing;Emotions;Endocannabinoids;Evaluation;Exposure to;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;General Population;Goals;head-to-head comparison;improved;Impulsive Behavior;In Vitro;in vivo;innovation;Lead;lead optimization;Learning;Ligands;Maps;MAS1 gene;Medicine;Memory;Mental disorders;Metabolism;Modification;Nervous System;neural;Neuropeptides;neuropsychiatric disorder;neuropsychiatry;novel;Oncogenes;Orphan;Patients;Peptides;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacology Study;pharmacophore;Phenotype;post-traumatic stress;Prevalence;Process;Productivity;Property;Proteins;Psyche structure;Pyrazoles;receptor;response;Risk Behaviors;Rodent;Role;scaffold;Scientist;screening;Series;side effect;small molecule;Sulfonamides;Syndrome;System;Testing;Therapeutic;tool;Transgenic Animals

PROJECT_TITLE: In Vivo Probes of Mas1 Receptor

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE Arkansas and Louisiana have among the highest rates of adult obesity in the United States at 38.7% and 38.6%, respectively. Prevention and intervention efforts are needed to reduce the number of children who will become obese adults and suffer the host of negative health consequences that accompany it. This proposal will develop and test strategies to stop the use of detrimental feeding practices by early childhood educators which promote unhealthy weight trajectories, inappropriate eating behaviors and poor dietary outcomes for children.

PI_NAMEs: RUTLEDGE, JULIE ;SWINDLE, TAREN  (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Acceleration;Address;Administrator;Adult;adult obesity;Age;Arkansas;Behavior;behavior change;Body mass index;Caring;Child;Childhood;Consumption;Cues;Data;Deimplementation;design;Development;Diet;Diet Habits;dietary;Dietary intake;Dietary Practices;early childhood;Eating;Eating Behavior;Education;education resources;Effectiveness;effectiveness evaluation;effectiveness outcome;Elements;Environment;evidence base;Evidence based practice;Excision;experimental study;Exposure to;Failure;Feedback;feeding;Feeding Patterns;Food;Foundations;Fright;Future;Goals;Health;Health Food;Healthy Eating;healthy weight;Hunger;Hybrids;Hyperphagia;implementation strategy;improved;Individual;Informal Social Control;Intake;Intervention;Language;Learning;life span;Louisiana;Mediating;Mediator;Methods;novel;nutrition;Outcome;Outcome Measure;Parents;peer learning;Persons;preference;Prevention;Process;Randomized;Research;response;role model;Satiation;scale up;Site;Specific qualifier value;Testing;Theory of Change;Training;Trust;United States;uptake;virtual;Weight;willingness;Work

PROJECT_TITLE: Deimplementation of Inappropriate Feeding Practices in Early Care and Education Settings

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Radiation Oncology;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: ILLINOIS INSTITUTE OF TECHNOLOGY

ORG_STATE: IL

PHR: Relevance to public health The project will advance and clinically test an automated intraoperative fluorescence imaging technology to help cancer surgeons remove 100% of primary tumors when possible, reducing the need for follow up treatments like call-back surgery, radiation therapy, and/or chemoradiotherapy. Moreover, successful primary surgery can decrease patient morbidity and yield higher survival rates. The proposed fluorescence imaging technology will be evaluated for head and neck squamous cell carcinoma surgery against state-of-the-art surgical guidance methods in an 80-patient clinical study, as a precursor to a future phase II clinical trial where the technology is expected to have positive impact on patient survival and quality of life.

PI_NAMEs: TICHAUER, KENNETH  (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Academic Medical Centers;Addendum;Address;Adjuvant;Adjuvant Therapy;Anatomy;Antibodies;Callback;cancer cell;cancer surgery;chemoradiation;Clinical;Clinical Research;Clinical Trials;clinically relevant;clinically significant;Collaborations;Computer Simulation;Data;Data Analyses;design;Detection;Diagnosis;Disease;Disease-Free Survival;Epidermal Growth Factor Receptor;Excision;Exclusion;Fluorescence;fluorescence imaging;follow-up;Frozen Sections;Future;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Head and Neck Surgeon;Health;Histopathology;Home;Illinois;Image;image processing;imaging approach;imaging Segmentation;imaging system;Imaging technology;improved;Individual;innovation;lens;Light;Lighting;Location;machine learning algorithm;Malignant Neoplasms;Manuals;maxillofacial;Methods;Morbidity - disease rate;Netherlands;Noise;Operative Surgical Procedures;Optics;Oral;Pathology;Patients;Pattern Recognition;Performance;Phase II Clinical Trials;Primary Neoplasm;Procedures;Property;Protocols documentation;prototype;Public Health;Quality of life;Radiation therapy;Reader;Reconstructive Surgical Procedures;Recurrence;Resected;Resources;Signal Transduction;Source;Specificity;Specimen;Spottings;Surface;Surgeon;Surgical margins;Survival Rate;System;Technology;Testing;tissue processing;Tissues;Training;tumor;Validation

PROJECT_TITLE: Ex vivo intraoperative surgical basal margin analysis in head and neck cancer resection: clinical validation

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Kidney Disease;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Our long-term objective is to develop monitoring for histotripsy with ultrafast, bubble-specific ultrasound imaging for effective, safe, and rapid ablation of renal cell carcinoma to decrease patient morbidity and mortality. In this project, we aim to refine and integrate ultrafast imaging onto a clinical-grade platform to facilitate rapid adoption, and develop and test feedback algorithms in ex vivo malignant renal tissues and a relevant large animal model.

PI_NAMEs: BADER, KENNETH B. (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Ablation;Acute;Address;Adoption;Aging;Algorithms;Animal Model;Automation;Clinical;Clinical Trials;clinically relevant;Collaborations;Common Neoplasm;comorbidity;Detection;Ensure;Family suidae;Feedback;Focused Ultrasound Therapy;Healthcare;Image;imager;imaging platform;imaging system;improved;In Vitro;in vivo;Kidney;Kidney Neoplasms;Liver neoplasms;Malignant - descriptor;Malignant Neoplasms;Methods;millisecond;Modeling;Monitor;Morbidity - disease rate;Morphologic artifacts;mortality;Mus;Newly Diagnosed;Oncology;Operative Surgical Procedures;Outcome;overtreatment;Patients;Physiologic pulse;Population;pre-clinical;Procedures;Property;Protocols documentation;Pulse Rates;Qualifying;Renal Cell Carcinoma;Renal Tissue;research clinical testing;Resolution;Safety;Schedule;Source;Specificity;Specimen;System;Testing;Time;Tissues;Transducers;Translating;translational potential;treatment duration;Treatment outcome;tumor;tumor ablation;Ultrasonography;United States;urologic;Validation

PROJECT_TITLE: Imaging Feedback for Histotripsy Renal Tumor Ablation


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE While chimeric antigen receptor T cell (CAR T) therapy represents a major advancement in the cancer immunotherapy field, these ‘living drugs’ face several barriers to their widespread success, including the inability to discern their fate after infusion. Here we propose a new in vivo approach to monitor CAR T cells with high specificity using immuno-positron emission tomography (immunoPET), a rapidly expanding area of molecular imaging. Specifically, we will develop and characterize the first human-specific immunoPET probes for OX40 and ICOS, two cell-surface antigens that are upregulated on activated T cells (including CAR Ts) with the long- term goal of clinical translation to improve patient outcomes by enabling non-invasive monitoring of responses to CAR T and other immunotherapies.

PI_NAMEs: JAMES, MICHELLE LOUISE (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Affinity;Antibodies;Area;Binding;Biological;cancer immunotherapy;CAR T cell therapy;CD19 gene;Cell Cycle Kinetics;Cell Proliferation;Cell Therapy;Cells;cellular imaging;chimeric antigen receptor T cells;Clinical;clinical translation;clinically relevant;Copper;Data;design;Detection;Development;Engineering;Engraftment;experimental study;Face;Failure;FDA approved;functional status;Goals;Hematologic Neoplasms;Human;Human body;Image;imaging agent;imaging biomarker;imaging modality;Imaging Techniques;Immunocompetent;Immunoconjugates;Immunoglobulin Fragments;Immunologic Monitoring;immunoreactivity;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;in vivo imaging;in vivo Model;in vivo monitoring;Infusion procedures;Investments;Kinetics;Label;Liquid substance;Modeling;molecular imaging;Monitor;Monoclonal Antibodies;mouse model;Mus;non-invasive imaging;non-invasive monitor;novel;novel strategies;outcome prediction;OX40;Patient-Focused Outcomes;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Positron-Emission Tomography;pre-clinical;Prediction of Response to Therapy;Protocols documentation;Radio;Radioisotopes;Radiolabeled;radiotracer;Reporter Genes;response;Safety;safety assessment;Sensitivity and Specificity;Solid Neoplasm;spatiotemporal;Specificity;success;Surface Antigens;T cell response;T-Cell Activation;T-Lymphocyte;targeted imaging;Techniques;Therapy Clinical Trials;Tracer;trafficking;Treatment Efficacy;Treatment Failure;tumor;Visualization;Zirconium

PROJECT_TITLE: Developing clinically relevant PET tracers to image T cell activation for improved cancer immunotherapy monitoring

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed research will establish a novel epigenetic ‘priming’ strategy designed to enhance PSMA expression and in turn augment clinical activity of PSMA-directed therapies such as 177Lutetium-PSMA-617. In addition to testing the effect of vorinostat (HDAC inhibitor) in a clinical trial, we will also conduct preclinical studies evaluating other epigenetic therapies alone and in combination, which will inform iterative clinical trials. Finally, we will evaluate imaging, tissue and blood-based predictive biomarkers, which will lead to new molecular diagnostics that will improve the lives and outcomes for patients with prostate cancer.

PI_NAMEs: HAFFNER, MICHAEL C (contact);SCHWEIZER, MICHAEL T

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Acute;American;androgen independent prostate cancer;Autopsy;biomarker development;Blood;Cancer Etiology;Cancer Patient;cancer site;Cessation of life;chemotherapy;Chromatin;Clinical;Clinical Data;clinical development;clinical efficacy;Clinical Trials;Collection;Data;Dependence;Deposition;design;Diagnostic;Disease;DNA;efficacy evaluation;Epigenetic Process;epigenetic therapy;FDA approved;fluorodeoxyglucose positron emission tomography;FOLH1 gene;Future;Genomics;Heterogeneity;Histone Deacetylase Inhibitor;Hypermethylation;Image;Immune response;improved;In Vitro;in vivo;innovative technologies;Link;Malignant neoplasm of prostate;Mediator;Membrane Glycoproteins;men;Metastatic Prostate Cancer;Modification;Molecular;molecular diagnostics;molecular imaging;molecular phenotype;novel;novel strategies;Outcome;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Phase;phase 2 study;Positron-Emission Tomography;pre-clinical;preclinical study;predictive marker;programs;Progression-Free Survivals;Prostatic Tissue;Radioisotopes;radioligand;Randomized;Reporting;Repression;Research;Resistance;resistance mechanism;response;Signal Transduction;Site;Surface Antigens;taxane;Testing;theranostics;Therapeutic;therapeutic development;Therapeutic Effect;tissue resource;Tissues;Tracer;trafficking;transcriptomics;Treatment Efficacy;tumor;Tumor Antigens;Universities;University resources;Vorinostat;Washington;Work

PROJECT_TITLE: Augmenting PSMA expression to enhance PSMA directed therapeutic efficacy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: The genetic code in heart and skeletal muscle are decoded by a unique molecular machine that is different from the rest of the body, mutations of which causes fatal heart failure in infants. The proposed studies investigate the mechanisms allowing specialized protein synthesis in the heart. Completion of this project will shed lights how heart works at the molecular level and lay the foundation for the development of new therapies for heart diseases.

PI_NAMEs: WU, XUEBING  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Address;Adult;Affinity;Alleles;Amino Acids;Biochemical;Biological Assay;Body Weight;Cardiac;Cardiac Myocytes;Cell Line;Cells;Codon Nucleotides;connectin;Coupled;Data;Dependence;Development;Dilated Cardiomyopathy;Disease;Dissection;Elongation Factor;Family;Foundations;Gatekeeping;Gene Duplication;Genes;Genetic;Genetic Code;Genomics;Growth;Heart;Heart Diseases;Heart failure;heart function;Heterozygote;Human;Human body;Human Cell Line;Image;In Vitro;in vivo;Infant;innovation;Luciferases;Mass Spectrum Analysis;misfolded protein;Missense Mutation;Modeling;Molecular;Molecular Chaperones;Molecular Machines;mouse model;Mus;Muscle;Muscle Cells;Mutate;Mutation;Myocardium;Neonatal;novel therapeutics;Nuclear;paralogous gene;Pathogenesis;Pathologic;Pattern;Physiological;Proteasome Inhibitor;Protein Biosynthesis;protein complex;protein degradation;protein folding;Proteins;Proteome;Proteomics;proteostasis;Pseudogenes;recruit;Reporter;Reporting;Rest;Ribosomal Proteins;ribosome profiling;Ribosomes;RNA immunoprecipitation sequencing;Role;Sarcomeres;segregation;skeletal;Skeletal Muscle;Speed;Striated Muscles;Surveys;System;Testing;therapeutic development;Tissues;transcriptomics;Translating;Translations;Validation;Work

PROJECT_TITLE: Mechanisms and functions of RPL3L ribosomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-A (02)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Narrative We propose to develop a novel highly sensitive technology for in vivo quantification of multiple metals in human bones. The proposed research is relevant to public health because once the technology is established, it can be broadly used to study chronic metal exposure and health, nutrition and health, and metal toxicity.

PI_NAMEs: NIE, LINDA H (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Adopted;Adoption;Adult;Aluminum;Biological Markers;Body Burden;bone;Cadaver;Calibration;Chronic;Clinical;clinical application;cohort;Communities;Computer software;Custom;Data;Data Analyses;design;Detection;detection limit;detection method;detection platform;detector;Deuterium;Deuterium Oxide;Diagnosis;Disease;Early Diagnosis;efficacy evaluation;Epidemiology;experience;Fast Neutrons;Gamma Rays;Goals;graduate student;Head;Health;health application;Human;Human body;human study;human subject;improved;in vivo;Indiana;Individual;Inductively Coupled Plasma Mass Spectrometry;instrument;Intake;Investigation;Iodine;irradiation;Magnesium;male;Manganese;Measurement;Measures;Metal exposure;metal poisoning;Metals;Methods;Monte Carlo Method;Neutron Activation Analysis;Neutrons;new technology;Non-Invasive Detection;novel;nutrition;operation;Optics;Organ;Patients;Photons;Play;Population;Potassium;prevent;Procedures;programs;prototype;Public Health;Radiation;Radiation Dose Unit;Radiation Physics;real world application;recruit;Reproducibility;Research;Research Personnel;Roentgen Rays;Role;Schools;Scientist;Shapes;Sodium;System;Systems Analysis;Technology;technology development;technology research and development;technology validation;Testing;thallium-doped sodium iodide;Thoracic Radiography;Time;Tissues;tool;Trace Elements;Training;Transportation;undergraduate student;user-friendly;Wisconsin;Work

PROJECT_TITLE: Highly Sensitive Novel Neutron Activation Analysis (NAA) Technology to Quantify Multiple Metals in Human Bone In Vivo

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA STATE UNIVERSITY

PHR: Project Narrative  Sulfation is the most common modification of carbohydrates yet is often overlooked. Effective and innovative methods will be developed and related enzymes will be expressed for facile synthesis of complex N- glycans and O-glycans with defined sulfation patterns. The resulting compounds are important standards for glycomics analysis and probes to understand the functions of sulfated glycans as well as many biological processes.

PI_NAMEs: LI, LEI  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Adopted;Affect;Anabolism;Biological;Biological Process;Carbohydrates;Cell Line;chemical synthesis;Chemicals;Complex;cystic fibrosis patients;Disease;Enzymes;Escherichia coli;Genetic study;Glycoproteins;glycosylation;glycosyltransferase;Guidelines;Homing;Individual;innovation;Insecta;Keratan Sulfate;Knowledge;L-Selectin;Label;Libraries;Ligands;Link;Location;Lymphocyte;Malignant neoplasm of ovary;Mammals;Methods;Modification;overexpression;Pathologic Processes;Pattern;physical property;Physiological;Play;Polymers;Polysaccharides;polysulfated glycosaminoglycan;Preparation;Process;Proteins;Reagent;recruit;Reporting;repository;Respiratory Tract Infections;Role;sialic acid binding Ig-like lectin;sialyl Lewis x;Specificity;Structure;Substrate Specificity;Sulfate;sulfotransferase;tool;Visit

PROJECT_TITLE: Programable Modular Synthesis of Sulfated N-Glycans and O-Glycans

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Epilepsy;Gene Therapy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative Biallelic mutations in the tubulin folding cofactor D (TBCD) gene result in a severe early-onset developmental and epileptic encephalopathy for which there is no treatment. Herein we will determine the neuropathological mechanisms of TBCD variants using patient derived cerebral organoids and investigate the molecular and clinical phenotypes in a corresponding allelic series of TBCD knock-in mouse models. We will then evaluate the efficacy of a targeted adeno-associated virus gene replacement therapy in our established models.

PI_NAMEs: BRADBURY, ALLISON M (contact);HESTER, MARK

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: adenovirus mediated delivery;Affect;Alleles;alpha Tubulin;Apoptosis;ARL2 gene;Astrocytosis;attenuation;beta Tubulin;Biochemical;Biological Assay;Brain;brain cell;Cell division;Cell Line;cell type;Cells;Cerebrum;Cessation of life;Clinical;Clinical Data;clinical phenotype;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;cohort;Complex;Cortical Malformation;CRISPR/Cas technology;Data;Dependovirus;Development;Developmental Delay Disorders;Disease;disease phenotype;Disease Progression;disease-causing mutation;early onset;efficacy evaluation;Electroencephalography;Electrophysiology (science);Encephalopathies;Epilepsy;epileptic encephalopathies;Exhibits;Functional disorder;functional loss;gait examination;gene correction;Gene Expression;gene replacement;gene replacement therapy;gene therapy;Genes;Growth;Histologic;Human;Immobilization;improved;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;insight;interdisciplinary approach;Knock-in;Knock-in Mouse;Knockout Mice;Lead;loss of function;Magnetic Resonance Imaging;Mediating;Microcephaly;Microtubules;migration;Modeling;Molecular;Molecular Chaperones;molecular phenotype;mouse model;multi-electrode arrays;Mus;Muscle hypotonia;Mutation;myelination;Nature;Nerve Degeneration;neurodevelopment;Neurodevelopmental Disorder;Neuronal Differentiation;Neurons;neuropathology;novel;novel therapeutic intervention;Ontology;Organoids;Outcome Measure;Pathogenesis;Pathogenicity;Patients;Peripheral;Phenotype;Play;premature;promoter;Proteins;Regulatory Pathway;Reporting;Role;Series;single-cell RNA sequencing;spasticity;Specificity;Spinal Cord;stem cell proliferation;stem cells;Testing;therapeutic development;Tissues;Transgenic Mice;Translations;Treatment Efficacy;Tubulin;Variant;variant of unknown significance;ventilation;Weaning

PROJECT_TITLE: Uncovering mechanisms and developing novel therapeutic strategies for TBCD-related developmental and epileptic encephalopathy

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_DEPT: NEUROSURGERY

PHR: Project Narrative The brain neurons that control movement and executive function in mammals are born at the same time from the same parent cells, but they develop to give rise to completely different connections and functions. How genes are regulated to control these fate choices is not well understood: we propose to study the intersecting roles of gene accessibility and gene repression in the normal development of uniquely mammalian brain connections serving movement and executive function. Completion of our Aims could lead to novel treatments for conditions like autism, cerebral palsy, and paralysis.

PI_NAMEs: THARIN, SUZANNE AUDREY (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;ATAC-seq;autism spectrum disorder;Axon;axon guidance;Behavior;Bioinformatics;Biological Assay;Biology;Brain;Cells;Central Nervous System;Cerebral cortex;Cerebral Palsy;Chromatin;cognitive skill;Complex;Corpus Callosum;Corticospinal Tracts;crosslink;Data;deep sequencing;Development;Embryo;Enhancers;Epigenetic Process;Evolution;executive function;gain of function;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Genomics;Immunoprecipitation;imprint;in vivo;Individual;insight;knock-down;loss of function;Mammals;Mediating;Messenger RNA;Methylation;MicroRNAs;Motor;Motor Neurons;Motor Skills;Movement;Mus;netrin receptor;Neurodevelopmental Disorder;neuron development;Neurons;Neurosciences;novel;overexpression;Paralysed;Parents;Pathway interactions;placental mammal;Play;progenitor;promoter;Regulation;Reporter;Repression;Role;selective expression;Shapes;Signal Transduction;Specific qualifier value;Spinal cord injury;Testing;Time;transcription factor;Traumatic Brain Injury;Work

PROJECT_TITLE: An evolutionarily acquired microRNA cluster shapes development of mammalian cortical projections

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Aging;Diabetes;Genetics;Nutrition

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Project Narrative Beta cells secrete insulin in response to changes in blood glucose levels to regulate glucose homeostasis. How beta cell heterogeneity is modulated during metabolic or age-related stress remains largely unknown. Un- derstanding these processes can lead to new ways to improve beta cell function during diabetes and aging.

PI_NAMEs: ARROJO E DRIGO, RAFAEL  (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: 3-Dimensional;Adult;Affect;age related;Aging;Beta Cell;Blood Glucose;blood glucose regulation;Caloric Restriction;Cell Aging;Cell Maturation;Cell Physiology;Cells;Cellular Stress;Cellular Structures;Characteristics;Chromatin;Chronic;circadian regulation;comparison control;Data;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diet;dietary control;dieting;Disease;DNA Damage;Economic Burden;Electrons;endoplasmic reticulum stress;Epigenetic Process;epigenetic profiling;epigenome;expectation;experience;experimental study;Exposure to;Face;Functional disorder;Gene Silencing;Genes;Genetic Transcription;Genome;genomic locus;Genomics;Glucose;Goals;hallmarks of aging;Health;Heterogeneity;High Fat Diet;histone modification;Histones;Homeostasis;Hormones;Human;human old age (65+);Immunocompromised Host;Impairment;improved;In Situ;In Vitro;in vivo;Individual;insight;Insulin;insulin secretion;insulin sensitivity;islet;Islet Cell;Islets of Langerhans Transplantation;Isotopes;Label;Light;Longevity;Lysine;Maps;Mass Spectrum Analysis;Metabolic;metabolic phenotype;Methylation;Microscopy;Mitochondria;Molecular;multiple omics;Mus;Nitrogen;Non-Insulin-Dependent Diabetes Mellitus;Normalcy;Pathway interactions;Patients;Pattern;Peripheral;Physiological;Population;postmitotic;Prediabetes syndrome;preservation;prevent;Process;Production;Proliferating;promote resilience;Property;Proteins;proteostasis;Resolution;response;Sense Organs;social;spectroscopic imaging;stable isotope;Stress;Structure of beta Cell of islet;Techniques;tool;transcription factor;transcriptomics;transplant model;Up-Regulation;Work

PROJECT_TITLE: Beta cell adaptation mechanisms during caloric restriction and ER stress

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE: The proposed research is relevant to public health because the discovery of vulnerabilities in the chemoresistant cell states found at tumor relapse is expected to lead to the development of more effective approaches to therapy in these high-risk states. Thus, the proposed research is relevant to the NCI mission of advancing fundamental knowledge to enhance health and reduce illness and disability from cancer.

PI_NAMEs: DURBIN, ADAM DAVID (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: Acute;Adrenergic Agents;Animal Model;Automobile Driving;Biological;Biology;Cancer Biology;cancer cell;Cells;Chemicals;Chemoresistance;chemotherapy;Child;Childhood;Clinical;clinically significant;cohort;Combined Modality Therapy;Common Neoplasm;Computational Biology;conventional therapy;Coupled;Data;Development;disability;Epigenetic Process;epigenomics;flexibility;Genes;Genetic;Genetic Transcription;Genome engineering;Genome Stability;Goals;Health;Heterogeneity;high risk;Immunotherapy;In Vitro;in vivo;innovation;Knock-out;Knowledge;Laboratories;Maintenance;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;malignant phenotype;Medicine;Mesenchymal;Mission;Modeling;mRNA Differential Displays;multidisciplinary;Mutation;neoplastic cell;Neuroblastoma;neuroblastoma cell;novel strategies;Pediatric Oncology;Peptide Initiation Factors;Play;Population;Process;Property;Public Health;Recurrent disease;Regulation;Relapse;Reporter;Research;Resistance;Role;RUNX1 gene;Specific qualifier value;stressor;Survival Rate;System;targeted cancer therapy;targeted treatment;Testing;Therapeutic;therapy resistant;tool;transcription factor;Transcriptional Regulation;transcriptome;transcriptomics;tumor;Work

PROJECT_TITLE: Dissecting high-risk cell states in neuroblastoma

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: FORT COLLINS

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative Maternal obesity with hyperphagia is a risk factor for preeclampsia, pregnancy hypertension, and offspring cardiometabolic disease. In utero programming of female offspring during preeclampsia contributes to the lifecycle of disease in women as a sex and gender. Investigating the maternal obesogenic environment is warranted to halt the transgenerational programming of cardiometabolic disease risk.

PI_NAMEs: SONES, JENNIFER LIFORD (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Abnormal placentation;Adipocytes;Adipose tissue;Adult;Adult Children;adverse outcome;adverse pregnancy outcome;angiogenesis;Attenuated;attenuation;Binding;Blood flow;Blood Pressure;Blood Vessels;Body Weight decreased;Cardiac;cardiac angiogenesis;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cells;Cessation of life;Characteristics;Clinical;Complication;Conceptions;Data;Decidua;Development;Disease;disorder risk;early pregnancy;Embryo;Energy Metabolism;Environment;Etiology;experimental study;feeding;Female;fetal;Fetal Growth Retardation;fetal programming;Fetus;fitness;Functional disorder;Gender;Goals;Health;heart function;Histologic;Hyperphagia;Hypertension;hypoperfusion;Hypoxia;Immune;immunoregulation;Impairment;improved;in utero;in vivo;Inflammation;Inflammation Mediators;inflammatory marker;Injury;Interleukin-6;Intervention;ischemic cardiomyopathy;Leptin;Life Cycle Stages;Link;Macrophage;male;maternal hypertension;maternal morbidity;maternal obesity;maternal serum;Maternal-Fetal Exchange;Measures;Metabolic;Modeling;mortality;Mothers;mouse model;Multiple Organ Failure;Mus;Natural Killer Cells;neonatal morbidity;novel;Obesity;obesogenic;offspring;Outcome;Oxygen Consumption;Pathogenesis;Perfusion;Placenta;Placentation;Play;Population;Pre-Eclampsia;Pregnancy;pregnancy hypertension;pregnant;prenatal;prevent;Proteinuria;Resolution;restoration;Risk Factors;Role;sex;single cell sequencing;Source;STAT3 gene;Stromal Cells;Testing;Thermogenesis;Time;TNF gene;transcriptome;Umbilical Blood;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factors;Woman

PROJECT_TITLE: Mechanisms of maternal obesity and feto-placental development in preeclampsia

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: AG

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Down Syndrome;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Prevention;Telehealth

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Adults with Down syndrome (DS) have a 75-90% lifetime risk of Alzheimer’s disease (AD), making this a significant issue for the DS community and broader public health concern. Currently, research studies and AD clinical trials rely on in-person testing options for adults with DS and development of remote testing options will benefit study design, reduce participant burden, and increase the probability of diverse participant inclusion in DS research. This study will transition promising measures for tracking early AD from in-person to remote administration, providing an innovative and novel data collection approach for monitoring participant performance in research studies and clinical trials in adults with DS that will directly benefit projects funded through NIH INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE).

PI_NAMEs: SCHWORER, EMILY KATHERINE (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Age;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloid beta-Protein;Assessment tool;Behavior Therapy;Behavioral;Biological Markers;Blood;Caregivers;Clinic;Clinical;Clinical Trials;Cognition;Cognitive;cognitive change;cognitive performance;cognitive testing;Communities;community research;cost;Data Collection;Dementia;Development;Disease Progression;Down's Syndrome;early detection biomarkers;Economics;Ensure;Ethnic Population;Evaluation;experience;extracellular;Family;Family member;feasibility testing;Feedback;follow-up;Frequencies;frontier;Funding;Future;Glial Fibrillary Acidic Protein;Goals;Health;Hour;Impaired cognition;improved;Individual;innovation;International;Interview;Investigation;Life;life span;lifetime risk;Longitudinal Studies;Measurement;Measures;Mentors;Methodology;Modification;Monitor;Neurofibrillary Tangles;novel;Outcome;Outcome Measure;Participant;Pathology;Patient Recruitments;Performance;performance tests;Persons;Pharmacologic Substance;Phase;Plasma;Prevention;Probability;Procedures;programs;Property;Psychometrics;Public Health;Questionnaires;racial population;recruit;Registries;remote administration;remote assessment;remote grading;Reporting;Research;Research Design;Research Personnel;Research Project Grants;research study;Resources;Rural Community;Sampling Studies;Science;Site;Standardization;Symptoms;tau Proteins;Techniques;Testing;Time;Training;Travel;trial readiness;United States National Institutes of Health;Validity and Reliability;Visit;Wisconsin;Work

PROJECT_TITLE: Remote assessments for Alzheimer’s disease cognitive decline in adults with Down syndrome

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Biotechnology;Immunotherapy;Nutrition;Obesity;Precision Medicine;Rheumatoid Arthritis

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE Biomarker signatures might represent a more realistic personalized medicine approach to match rheumatoid arthritis (RA) patients with the most appropriate therapeutic option to optimally control immune driven inflammation and thereby minimize joint destruction in this disease. Prior studies have highlighted strong associations between body weight and RA disease outcomes suggesting an important relationship between inflammation, metabolism, and RA outcomes. We will characterize obesity-induced mediators to address the question of whether adipokines and inflammatory lipid profiling in plasma effectively predict patient response to therapy prior to administration.

PI_NAMEs: GUMA, MONICA  (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Achievement;Acids;active method;Address;adipokines;adiponectin;Adipose tissue;Aftercare;Analytical Chemistry;Anti-Tumor Necrosis Factor Therapy;Arthritis;arthritis therapy;B-Lymphocytes;Biological;Biological Markers;Biological Products;Biological Response Modifier Therapy;biomarker signature;Body mass index;Body Weight;Categories;Clinical;Clinical assessments;clinical phenotype;clinical predictors;cohort;comparative effectiveness;cytokine;Diabetes Mellitus;Discrimination;Disease;Disease Outcome;Disease remission;Disease-Modifying Second-Line Drugs;Elements;Endocrine;Endocrine Glands;experimental study;Exposure to;Fatty Acids;Future;Heterogeneity;high body mass index;Human;IL6 gene;Immune;indexing;Inflammation;Inflammation Mediators;Inflammatory;interest;joint destruction;Leptin;Leukotrienes;Link;lipidomics;Lipids;Mass Spectrum Analysis;Measures;Mediating;Mediator;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;Methods;new technology;Non obese;Obesity;Omega-6 Fatty Acids;Outcome;Participant;Pathogenesis;Pathway interactions;patient response;Patients;personalized medicine;personalized therapeutic;Persons;Phenotype;Plasma;Play;Polyunsaturated Fatty Acids;predicting response;Prediction of Response to Therapy;Predictive Factor;predictive marker;primary endpoint;Prior Therapy;prognostic value;Prostaglandins;Proteins;Protocols documentation;recruit;Recurrent disease;Registries;Relapse;Research Personnel;responders and non-responders;response;Rheumatoid Arthritis;Role;sample archive;Sampling;secondary endpoint;systemic inflammatory response;Systems Biology;T cell therapy;Therapeutic;TNF gene;treatment response;Work

PROJECT_TITLE: Obesity-Induced Inflammatory Mediators Predict Lack of Response in Patients with Rheumatoid Arthritis Starting Biological Therapies

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Public Health Relevance Statement While up to 50% of patients with GDM require the addition of a medication during pregnancy, the long-term effects of medication treatment of GDM are largely unknown. Using state-of-the-art statistical methods, we will compare GDM medications (metformin, glyburide, insulin) on long term risk of maternal diabetes and childhood obesity.

PI_NAMEs: HEDDERSON, MONIQUE MARIE (contact);NEUGEBAUER, ROMAIN ;XIANG, ANNY H

PROGRAM_OFFICER_NAME: LAWRENCE, JEAN M

PROJECT_TERMS: 9 year old;active comparator;Adherence;Adult;Affect;American;Animals;Beta Cell;Binding;Body mass index;California;Categories;Child;Clinical;Clinical Data;clinical practice;Cohort Studies;college;cost;Data;Deterioration;Diabetes Mellitus;diabetes risk;Diagnosis;Diet therapy;Discipline of obstetrics;Dose;Electronic Health Record;Epigenetic Process;ethnic minority population;Ethnic Origin;Exclusion Criteria;Exposure to;fetal;Fetal Growth;fetal programming;Fetal Tissues;follow-up;Gestational Age;Gestational Diabetes;gestational weight gain;Glucose;glucose production;Glyburide;glycemic control;Growth;Guidelines;Gynecologist;head-to-head comparison;Hepatic;Incidence;Individual;Infant;Insulin;insulin sensitivity;Intention;Intestinal Absorption;Long-Term Effects;long-term sequelae;Longitudinal cohort study;Longterm Follow-up;Low Birth Weight Infant;Machine Learning;Maternal and Child Health;maternal diabetes;maternal obesity;maternal risk;Medical;member;Metformin;Methodology;Methods;Mitochondria;Modernization;Modification;Mothers;Nutritional Support;Obesity;obesity in children;obesity risk;Observational Study;optimal treatments;Oral;Outcome;overweight child;Participant;Patients;perinatal complications;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Placenta;Population Heterogeneity;post pregnancy;postnatal;pragmatic randomized trial;Pregnancy;Pregnancy Complications;pregnant;Prevalence;progression risk;Protocols documentation;public health relevance;Race;racial difference;racial minority population;Randomized, Controlled Trials;receptor;Recommendation;Regimen;Respiration;Risk;Risk Reduction;Sample Size;Selection Bias;Series;Specific qualifier value;Stable Populations;Statistical Methods;study population;Time;treatment as usual;Treatment Protocols;treatment strategy;trial comparing;Uncertainty;Variant;Weight Gain;Woman

PROJECT_TITLE: Comparing the effects of pharmacological treatment for gestational diabetes on long-term maternal and child health outcomes

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative Inherited heart diseases are a significant cause of death and morbidity with limited options of treatment largely due to the poor understanding of the underlying mechanisms of impaired heart muscle contractility. The goal of this project is to understand how contractility is regulated in healthy pig heart muscle and how contractility is dysregulated in diseased heart muscle. Such understanding can provide important guidance towards mitigating the root causes of these diseases via more targetted approaches than with current therapies that mainly focus on alleviating symptoms.

PI_NAMEs: WEIKANG MA, WEIKANG MA WEIKANG MA (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Actins;Actomyosin;Adrenergic Agents;base;Biochemical;Biological Assay;Biological Models;Calcium;Calcium Binding;cardiac muscle disease;Cardiomyopathies;Cause of Death;Characteristics;Complex;connectin;Contracts;Cyclic AMP-Dependent Protein Kinases;Defect;Depressed mood;Dilated Cardiomyopathy;Disease;Event;Family suidae;FDA approved;Functional disorder;Goals;Head;Heart;Heart Diseases;Human;Hypertrophic Cardiomyopathy;Impairment;improved;Inherited;Laboratories;Length;Light;Mechanics;Mediating;Microfilaments;Modeling;Molecular;Molecular Conformation;Morbidity - disease rate;Muscle;Muscle function;Mutate;Mutation;Myocardial;Myocardium;Myosin ATPase;myosin-binding protein C;new therapeutic target;Pathologic;Phenotype;Phosphorylation;Physiological;Point Mutation;porcine model;Positioning Attribute;Proteins;reduce symptoms;Regulation;Regulatory Pathway;Relaxation;response;Rest;Restrictive Cardiomyopathy;Rodent;Sarcomeres;Stretching;Striated Muscles;Symptoms;System;Testing;Therapeutic;therapeutic target;Thick Filament;Thin Filament;Time;Troponin;Troponin I;Vertebral column;Work;X ray diffraction analysis

PROJECT_TITLE: Thick filament regulation mechanisms in healthy and diseased  myocardium

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Prevention;Social Determinants of Health;Teenage Pregnancy;Women's Health Research

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: Project Narrative This study seeks to evaluate an innovative multilevel intervention to increase contraceptive use in rural Uganda, which has among the highest unmet needs for family planning and fertility rates in the world. By addressing multilevel barriers to family planning, this intervention can help couples to better space and time their pregnancies, reduce the incidence of unintended pregnancy, and ultimately reduce rates of maternal and infant morbidity and mortality.

PI_NAMEs: KIENE, SUSAN MARIA;MUHUMUZA, CHRISTINE ;SILEO, KATELYN MARY (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;Address;Adoption;Affect;Age;AIDS prevention;arm;Attention;Attitude;avoid pregnancy;Cessation of life;Child;Child Development;Child Nutrition;Cluster randomized trial;Communication;Communities;community based participatory approach;community intervention;comparative efficacy;Comparison arm;condoms;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Couples;Data;Death Rate;Decision Making;Economics;Education;efficacy evaluation;efficacy testing;Family;Family health status;family influence;Family Planning;Family Sizes;Fertility Rates;follow-up;Fright;Future;Gender;gender equity;Gender Role;girls;Goals;Health;Health Benefit;Health system;Hygiene;implementation intervention;improved;Incidence;Individual;Inequity;infant morbidity/mortality;Infant Mortality;information gathering;innovation;interest;Intervention;intervention effect;Investments;Joints;Knowledge;Live Birth;low and middle-income countries;low income country;maternal morbidity;Maternal Mortality;Mediating;Mediator;men;Methods;Misinformation;Modeling;Modernization;Mother-to-child HIV transmission;Outcome;Partner Communications;peer influence;Perception;pilot trial;Pregnancy;pregnancy prevention;primary outcome;process evaluation;Provider;Public Health;Quality of Care;Randomized, Controlled Trials;reproductive;Resource-limited setting;Risk;Rural;rural area;Sampling;Sanitation;scale up;secondary outcome;Services;Shapes;Side;side effect;social;success;Sustainable Development;Testing;Time;Transportation;Treatment Efficacy;Uganda;unintended pregnancy;United Nations;United States;uptake;Water;Woman;Work

PROJECT_TITLE: Efficacy Testing of a Multi-Level Family Planning Intervention to Increase Contraceptive Use and Reduce Unintended Pregnancy in Low Resource Settings

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative: We discovered that each of the cardinal interneuron classes of the spinal cord can be divided into two subtypes - one with local connections and one with long range connections, based on a conserved set of genetic signatures. These findings reveal a previously unappreciated organizational principle of the spinal cord, but lead to the question why did nature duplicate the cardinal cell groups creating these subsets? This grant will examine whether these newly identified long/short range connectivity divisions of the cardinal classes represent distinct neural units for motor behavior.

PI_NAMEs: PFAFF, SAMUEL L. (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Anatomy;Animals;Atlases;Behavior;Behavioral;Brain region;cell type;Cells;Code;Contralateral;Cues;Data;designer receptors exclusively activated by designer drugs;Development;dexterity;Electrodes;excitatory neuron;extracellular;flexibility;Genetic;genetic approach;Genetic Code;genetic signature;Goals;Grant;Hindlimb;Histologic;in vivo;inhibitory neuron;innovation;Interneurons;Joints;Label;Lateral;Lead;Left;Limb structure;Link;Logic;Medial;Mediating;Methods;Motor;motor behavior;motor control;Mus;Muscle;Nature;neural;neural network;Neurons;Neurotransmitters;novel;optogenetics;Output;Pathway interactions;Phenotype;Physiological;Play;Population;Positioning Attribute;Process;Property;receptor;Reflex action;Role;scaffold;Science;Sensory;Series;Signal Transduction;Site;Spinal;Spinal Cord;Subcategory;Synapses;Synaptophysin;System;Techniques;Testing;tool;Transcend;transcriptomic profiling;Viral;Virus;vision science;ZFHX3 gene

PROJECT_TITLE: Dissecting local (N) and long range (Z) circuit modules within the spinal cord

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Aging;Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Social Determinants of Health

ORG_CITY: SAN MARCOS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: TEXAS STATE UNIVERSITY

PHR: Narrative This project aims to quantify the effects of sustained volunteering on multiple modifiable cardiovascular disease (CVD) biomarkers while considering the selection into volunteering, genetic susceptibility for clinically high CVD biomarkers, and the effect heterogeneity in multiple population subgroups. Findings from this ten-year longitudinal study of older adults will inform the optimal level of volunteering among older adults, identify which population subgroups should be targeted for volunteering interventions, and show how genetic information informs research on volunteering and health. This study will also provide insight for future research to examine the complex trajectory of volunteering and cardiovascular health in middle-aged and older adults.

PI_NAMEs: KIM, SEOYOUN  (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Address;Adult;Affect;African;African ancestry;Age;Behavioral;biobehavior;Biological;Biological Markers;blood pressure reduction;Body mass index;C-reactive protein;Cardiac health;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cause of Death;Characteristics;Cholesterol;Chronic;Clinical;Communities;Complex;cost effective;Data;Data Set;Diastolic blood pressure;Education;European;European ancestry;Female;Frequencies;gene environment interaction;Genetic;genetic information;genetic predictors;Genetic Predisposition to Disease;Genetic Risk;genome wide association study;Glycosylated hemoglobin A;Health;Health and Retirement Study;health data;Health Policy;Heart;Heterogeneity;High Density Lipoproteins;Hour;Hypertension;Individual;Inflammation;inflammatory marker;insight;Intervention;Knowledge;Link;Lipids;Literature;longitudinal analysis;Longitudinal Studies;Machine Learning;male;Maximum Likelihood Estimate;Meta-Analysis;Methods;middle age;Modeling;Obesity;older adult;Pathway interactions;polygenic risk score;Population;post gamma-globulins;Probability;Protein C;Public Health;public health intervention;random forest;rate of aging;Recovery;Reporting;Research;Research Priority;response;Risk;Risk Factors;Role;secondary analysis;Services;sex;social;social factors;social interventions;Socioeconomic Factors;socioeconomics;Subgroup;Testing;theories;Time;treatment effect;volunteer

PROJECT_TITLE: Volunteering, Polygenic Risk, and Cardiovascular Biomarkers in Multiple Ancestry Groups

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Clinical Research;Infectious Diseases;Orphan Drug;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE: Hidradenitis suppurativa (HS) is a chronic, inflammatory, debilitating skin disease that is treated symptomatically, but only a subset of its symptoms can be identified clinically by visual inspection and palpation, which is the current standard of care in the United States. This project proposes development of an advanced photoacoustic and ultrasound imaging system with an easy-to-use hand-held probe that will generate a 3D map of likely HS involvement throughout the epidermis, dermis, and hypodermis. The proposed photoacoustic/ultrasound imaging system and associated HS-detection algorithm not only hold promise for reducing HS morbidity in direct clinical use by enabling more accurate surgeries and better-targeted pharmacological treatments but will also assist future HS investigators to develop more effective drugs and individualized therapeutic strategies.

PI_NAMEs: AVANAKI, KAMRAN  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 3-Dimensional;3D ultrasound;Abscess;Acoustics;Advanced Development;Affect;Algorithms;Apocrine Sweat Gland;Area;Axilla;Biological Markers;Blood;Body Regions;Chronic;chronic inflammatory disease;Clinical;Clinical assessments;clinical translation;Collagen;Collection;cost;Data;Dermal;Dermatologic;Dermatologist;Dermatology;Dermis;design;Detection;Development;Diagnosis;Disease;Disease Progression;Effectiveness;Epidermis;Evaluation;Excision;experience;Furuncles;Future;Goals;Hair follicle structure;hemodynamics;Hidradenitis Suppurativa;Histologic;Histology;human imaging;Image;imaging biomarker;imaging modality;imaging system;indexing;individualized medicine;Inflammation;Inflammatory;International;Keratin;Lesion;Lipids;Liquid substance;Maps;Methods;Microbial Biofilms;Modeling;Monitor;Morbidity - disease rate;Nature;Nodule;Operative Surgical Procedures;Optics;Oxygen;Pain;Palpation;Pathologist;Patients;Perianal region structure;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacological Treatment;photoacoustic imaging;Physiological;portability;Probability;Pus;Quality of life;Quantitative Evaluations;radiologist;Recommendation;Recording of previous events;Recurrence;Research Personnel;Safety;Severities;Skin;skin disorder;Specific qualifier value;Staging;standard of care;Structural defect;structural imaging;subcutaneous;Subcutaneous Tissue;Surgeon;Surgical margins;Symptoms;System;Technology;Testing;three-dimensional visualization;Tissues;tool;Training;treatment comparison;Treatment Effectiveness;treatment planning;treatment response;Ultrasonography;ultrasound;United States;Vascularization;Visit;Visual;Visualization

PROJECT_TITLE: Combined Photoacoustic and Ultrasound Imaging for Enabling Quantitative Evaluation of Hidradenitis Suppurativa

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ORG_CITY: KANSAS CITY

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Osteoarthritis (OA) is the most prevalent joint disease in middle-aged and older populations. The objective of this proposal is to investigate the therapeutic role of NFAT1 treatment in joint tissue aging and OA development using OA mouse models and human joint-tissues with primary OA. Positive results of this preclinical project will promote the development of a personalized OA therapy in patients with significantly reduced NFAT1 expression or biological activities.

PI_NAMEs: WANG, JINXI  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: adenovirus mediated delivery;Adult;Age;Age Months;age related;aged;Aging;aging biomarker;aging population;aging related;Animals;Anti-Inflammatory Agents;Area;arthropathies;articular cartilage;Attenuated;Binding;Biological;Biological Assay;Blood;Body mass index;Cartilage;cartilage cell;cartilage degradation;Cells;ChIP-seq;Chondrocytes;Classification;Clinical Treatment;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen;Control Groups;cytokine;Data;Deformity;Degenerative polyarthritis;Dependovirus;Development;Disease;DNA Binding Domain;early onset;Enzymes;Exhibits;Family;Female;Functional disorder;Gene Dosage;gene editing technology;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Goals;Heterogeneity;Hip Osteoarthritis;Histologic;Homeostasis;Human;immunocytochemistry;Induced Mutation;Inflammation;Injections;Intra-Articular Injections;joint formation;joint injury;Joints;Knee;Knee joint;Knee Osteoarthritis;Luciferases;Mechanics;member;Metabolism;middle age;Molecular;mouse model;mRNA Expression;Mus;mutant;Mutate;Mutation;nuclear factors of activated T-cells;Older Population;Outcome Measure;overexpression;Pathogenesis;Pathogenicity;Pathway Analysis;Patients;pharmacologic;Plasmids;pre-clinical;prevent;Prevention;Process;radiological imaging;Reporter;response;Risk Factors;Rodent;Role;Severities;sex;skeletal;Skeletal Development;Somatic Mutation;Synovial Cell;Synovial Membrane;System;Testing;Therapeutic;Therapeutic Effect;therapeutically effective;Time;Tissue Sample;Tissues;transcription factor;transcriptome sequencing;Transgenes;treatment group;Validation;Weight-Bearing state;Wild Type Mouse

PROJECT_TITLE: Therapeutic role of NFAT1 Transcription Factor in Osteoarthritis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Rare Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Niemann-Pick C is an invariably fatal lysosomal disease affecting both the liver and brain. The relevance of the proposed studies to public health is that they will define the mechanisms which trigger liver dysfunction in Niemann-Pick C disease. This work is expected to identify novel pathways that significantly contribute to manifestations of Niemann-Pick C, thereby setting the stage for future discovery efforts to identify and test new therapeutic strategies.

PI_NAMEs: SCHULTZ, MARK LOUIS (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Address;Affect;Age;Age Months;Amino Acids;Applications Grants;Area;Autophagocytosis;autosome;Back;Biochemical;Biological;Biological Assay;Brain;brain tissue;Cells;Cholesterol;cholesterol transporters;Cirrhosis;Confocal Microscopy;Data;Defect;Degradation Pathway;Development;Disease;disease-causing mutation;Endoglycosidases;Endoplasmic Reticulum;Fatty Liver;Functional disorder;functional restoration;Future;Genes;Genetic;glycosylation;Goals;Grant;Half-Life;Hepatocyte;Hepatomegaly;Human;induced pluripotent stem cell;insight;interest;Intervention;Isoleucine;Knowledge;late endosome;Lentivirus;Link;Lipids;Liquid Chromatography;liquid chromatography mass spectrometry;Liver;Liver Dysfunction;Liver Failure;Location;loss of function mutation;Lysosomal Storage Diseases;Lysosomes;Mediator;Membrane Glycoproteins;Molecular Weight;multicatalytic endopeptidase complex;Mutate;National Institute of Diabetes and Digestive and Kidney Diseases;Neimann-Pick's Disease Type C;Neonatal;Neurologic;Neurons;new therapeutic target;novel;novel therapeutic intervention;Nuclear Pore Complex;Organ;Pathway interactions;Patients;Play;Polysaccharides;Positioning Attribute;Primary carcinoma of the liver cells;Process;protein degradation;protein folding;Protein Isoforms;Proteins;proteostasis;Public Health;Regulation;Research;Role;Site;Specificity;tandem mass spectrometry;Testing;Therapeutic;Threonine;Tissues;trafficking;Variant;Western Blotting;Work

PROJECT_TITLE: Investigating the importance of liver-specific glycans on NPC1 proteostasis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Obesity is a major public health problem because of its high prevalence and causal relationship with serious medical diseases, and particularly challenging in its treatment is lost weight maintenance—lost weight is often regained. Here, we will investigate how obesity alters the function of brain areas that govern appetite and body weight regulation. This work will be critical for understanding how obesity changes the brain, and for informing therapeutic approaches for improving the ability of people with obesity to lose weight and keep it off.

PI_NAMEs: KRAVITZ, ALEXXAI V (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acute;Adipose tissue;Animals;Area;Attenuated;Behavioral;Body Weight;Body Weight decreased;Brain;Calcium;cell type;Chronic;Clinical;comorbidity;Data;Deep Brain Stimulation;Desire for food;Disease;Dopamine D2 Receptor;Eating;Electrophysiology (science);experience;experimental study;Exposure to;feeding;Food;Foundations;genetic approach;Goals;Health;Heart Diseases;High Fat Diet;High Prevalence;hormonal signals;Hour;Human;improved;in vivo;in vivo calcium imaging;increased appetite;Intervention;Life;Link;Liquid substance;Malignant Neoplasms;mathematical model;Measures;Medical;Meta-Analysis;metabolic rate;Methods;Monitor;Mus;neural;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Nucleus Accumbens;Obese Mice;obese patients;Obesity;obesity development;obesity treatment;Organ;Outcome;Output;Patients;Peripheral;Persons;pharmacologic;Physiological;Population;Property;Public Health;Quality of life;Regulation;Research;response;reward circuitry;Rewards;Risk;Rodent;Role;Structure;Synapses;System;Testing;Therapeutic;United States National Institutes of Health;virus genetics;Weight;Weight Gain;weight maintenance;Work

PROJECT_TITLE: Accumbal adaptations that contribute to weight regain after weight loss

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Prevention;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Narrative Sphingosine phosphate lyase insufficiency syndrome (SPLIS) is a rare metabolic disorder that affects the kidneys, brain, hormone-producing glands, skin and immune system. This study will characterize the features of the disease and quality of life of SPLIS patients and how they change over time. We also aim to develop laboratory tests that can help us monitor the health of SPLIS patients and detect the disease in dried blood spots as a newborn screening test.

PI_NAMEs: SABA, JULIE D (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Adrenal gland hypofunction;Affect;Autophagocytosis;Biological Markers;biomarker development;Blood;Blood specimen;Blood Tests;Brain;Catabolism;Cause of Death;Cell Line;Cessation of life;Child;Clinical;clinical trial enrollment;Clinical Trials;Coenzymes;Collection;Complete Blood Count;curative treatments;Defect;Dependovirus;Derivation procedure;detection method;Development;Diagnostic;Disease;Disease Outcome;disorder subtype;Dryness;Early Diagnosis;Early identification;Endocrine;Enzymes;Exhibits;Failure;Family;Fibroblasts;Foundations;Functional disorder;Future;gene therapy;Gland;Goals;Health;Hormones;Hypothyroidism;Immune;Immune system;immunodeficiency;Impairment;Inborn Errors of Metabolism;induced pluripotent stem cell;Intervention;Investigation;Kidney;Kidney Failure;Kidney Transplantation;Laboratories;Life;Lipids;Lyase;Lymphocyte Count;Lymphocyte Subset;Mass Spectrum Analysis;Measurement;Mediating;member;Metabolic Diseases;Metabolism;Methods;Monitor;mouse model;Mutation;Natural History;Neonatal Screening;Nephrotic Syndrome;nerve conduction study;Neurologic;Newborn Infant;novel;Organ;Outcome;Outcome Measure;Patient Selection;Patients;Plasma;Positioning Attribute;prevent;primary endpoint;Prospective Studies;Proteins;Quality of life;Questionnaires;Rare Diseases;Readiness;renal damage;Renal function;Research;Retrospective Studies;Saccharomycetales;Scientist;screening;Skin;skin barrier;skin biopsy;Sphingolipidoses;Sphingolipids;sphingosine 1-phosphate;sphingosine phosphate lyase insufficiency syndrome;sphingosine-1-phosphate lyase;Spottings;stem cells;Supplementation;survival prediction;Syndrome;targeted treatment;Tay-Sachs Disease;Testing;Therapeutic;Time;tool;treatment strategy;Vitamin B6;Whole Blood;Work;working group

PROJECT_TITLE: Characterizing the natural history of sphingosine phosphate lyase insufficiency syndrome (SPLIS): a fundamental step in the development of a targeted cure for this novel atypical sphingolipidosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-A (02)]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Skin Cancer

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This proposal aims to develop a soft magnetoelastic microneedle patch that enables the study of in vivo, rapid, and non-invasive characterization of skin mechanical properties on human subjects and establish its clinical significance for the pre-screening and early diagnosis of skin cancer. Moreover, the wireless transmitting features can provide extra information on time-dependent changes of tissue, facilitating further understanding of skin cancer progression. Such platform technology includes not just monitoring the stiffness of the tumor, but also stiffness changes during aging, wound healing, or other treatment processes.

PI_NAMEs: CHEN, JUN  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: 3D Print;Aging;Algorithms;Animals;Area;Atomic Force Microscopy;Benign;bioelectronics;Biological Monitoring;biomaterial compatibility;Biomechanics;Biopsy;Calibration;cancer diagnosis;Cancer Diagnostics;Caring;Chemicals;Clinic;clinically significant;Collaborations;Communication;convolutional neural network;cost;Data;Dermatologic;Dermoscopy;design;Detection;Diagnosis;Diagnostic;Doctor of Medicine;Doctor of Philosophy;Dorsal;Early Diagnosis;early screening;Elasticity;Electronics;Excision;experience;flexibility;Fright;Goals;Growth;Histologic;Histology;Human;Human body;human subject;Image;Immunohistochemistry;Implant;in vivo;innovation;Lesion;Liquid substance;Liver neoplasms;Machine Learning;Magnetism;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Measurement;Measures;mechanical properties;Mechanics;Melanoma;Methods;Microfabrication;Microscope;Modulus;Monitor;mouse model;multidisciplinary;Mus;Nature;Needles;neural network algorithm;Operative Surgical Procedures;Optics;Organ;Patient Triage;Persons;Photography;Process;rational design;Reproducibility;Resolution;Scanning;screening;Screening for Skin Cancer;Signal Transduction;Skin;Skin Cancer;Skin Carcinoma;skin lesion;smart device;standard of care;subcutaneous;success;System;Techniques;Technology;technology platform;Testing;Time;Tissues;tool;Training;tumor;tumor progression;ultra high resolution;United States;Viscosity;Visualization;wearable device;wireless transmission;Work;wound healing

PROJECT_TITLE: A soft magnetoelastic microneedle patch for rapid skin cancer screening

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (82)]


ORG_CITY: MERCED

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, MERCED

PHR: Public Health Relevance/Narrative Cell fate during human development requires the tight regulation of global gene expression programs that are controlled by pioneer transcription factors (PTFs). These PTFs must recognize specific DNA sequences within very large regions of the chromatin on multiple chromosomes, by yet poorly understood mechanisms. The goal of this research is to understand the rules of PTF-DNA recognition within large regulatory regions and how these mechanisms translate to the cellular transcriptional decisions that ultimately lead to global gene regulation.

PI_NAMEs: MUNOZ, VICTOR  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Affect;Affinity;Binding;biophysical analysis;biophysical model;Blood;Body Patterning;Brain;Candida albicans;Candidiasis;Cell Fate Control;Cell Reprogramming;Cells;Chromatin;Chromosomes;Clinical;Closure by clamp;Code;conformational conversion;Defect;detection platform;Development;DNA;DNA Binding;DNA Binding Domain;DNA Sequence;Elements;Embryonic Development;Eye;Gene Expression;Gene Expression Regulation;Genetic;genetic manipulation;Genetic Models;Genetic Transcription;Genomic Segment;Goals;Home;Human;Human Development;In Vitro;in vivo;in vivo Model;Link;Malignant Neoplasms;Mechanics;Modeling;molecular imaging;Morphogenesis;Mycoses;novel;Nucleic Acid Regulatory Sequences;Nucleosomes;Organism;Pattern;Play;Process;programs;Property;public health relevance;Readability;recruit;Regenerative Medicine;Regulation;Regulatory Element;Research;Resolution;Role;Scanning;Shapes;single molecule;Skin;Slide;stem cell differentiation;Structure;Techniques;Tissues;transcription factor;transcriptome;Translating;tumor progression;Virulence

PROJECT_TITLE: Mechanisms for DNA Recognition, Scanning and Nucleosome Mechanical Actions by Pioneer Transcription Factors and their Role in Cell Fate Decisions

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]