NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Suicidal ideation and behaviors are common across the psychosis continuum, particularly among youth experiencing the earliest signs and symptoms of a psychotic disorder. Despite the high risk for suicidal ideation and behavior in this group, there are currently no suicide prevention approaches specifically designed for youth at clinical high-risk for psychosis. This project will adapt the evidence-based “Youth-Nominated Support Teams” intervention, tailoring it for transition-aged youth and young adults receiving clinical high-risk for psychosis mental health services. Using client, family, and stakeholder input, we will develop, implement, and revise the intervention, and then test its impact in a preliminary randomized trial at four psychosis-risk clinics.

PI_NAMEs: DEVYLDER, JORDAN ;SCHIFFMAN, JASON E (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: acceptability and feasibility;active control;Address;Adherence;Adolescent;Adolescent and Young Adult;aged;brief intervention;Caring;Client;Clinic;Clinical;clinical high risk for psychosis;Clinical Research;Clinical Trials;Collaborations;comparative efficacy;Consensus;Coordinated Specialty Care;cost effective;Data;Death Rate;depressive symptoms;design;Development;Diagnosis;Dissemination and Implementation;Distal;duration of untreated psychosis;Early Intervention;efficacy testing;evidence base;Evidence based practice;Exclusion;experience;Family;Family member;Feasibility Studies;feasibility testing;Feeling hopeless;Feeling suicidal;Focus Groups;follow-up;Friends;Funding;Grant;Health behavior;health service use;high risk;high risk population;Impairment;Individual;Intervention;intervention delivery;Interview;Manuals;meetings;Mental Health;Mental Health Services;Meta-Analysis;Modeling;mortality;Participant;person centered;Persons;Phase;pilot trial;Population;Practice Guidelines;preference;Preparation;Prevalence;Prevention approach;prevention service;preventive intervention;programs;Protocols documentation;Provider;psychoeducation;Psychoses;psychosis risk;Psychotic Disorders;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Recording of previous events;Recovery;reducing suicide;Reporting;Research Personnel;Resources;response;Safety;Schizophrenia;Self-Injurious Behavior;Services;Signs and Symptoms;Site;social;Social isolation;Social support;Structure;success;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;support network;telehealth;Testing;Training;Treatment Protocols;treatment risk;United States Substance Abuse and Mental Health Services Administration;young adult;Youth

PROJECT_TITLE: Youth Nominated Support Team for Suicidal Adolescents at Clinical High Risk for Psychosis


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: INDIANAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative The objective of this R01 project is to identify potent, orally bioavailable and brain penetrant small-molecule degraders of SUMO1 protein as novel anticancer drugs for treatment of patients diagnosed with glioblastoma.

PI_NAMEs: HAMDOUCHI, CHAFIQ ;HAO, CHUNHAI CHARLIE (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: ABCB1 gene;absorption;Adverse effects;analog;anticancer activity;Antineoplastic Agents;Binding;Binding Proteins;Biological Assay;Biological Availability;Biological Products;blood-brain barrier permeabilization;Brain;Brain Neoplasms;Cells;Chemicals;chemotherapy;Chemotherapy and/or radiation;Clinical Management;Clinical Treatment;Clinical Trials;Complex;computational chemistry;counterscreen;CRISPR/Cas technology;CUL1 gene;curative treatments;Cytoplasm;design;Development;Diagnosis;Dose;drug discovery;Drug Kinetics;Drug Targeting;Excretory function;Formulation;genome-wide;Glioblastoma;Guidelines;Human;improved;In Vitro;in vivo;Knock-out;Lead;lead optimization;lead series;Libraries;Malignant Neoplasms;Metabolic;Metabolism;Modeling;Modification;Molecular;monolayer;National Cancer Institute;Neurosphere;novel;novel anticancer drug;novel therapeutics;Oncoproteins;Operative Surgical Procedures;Oral;patient derived xenograft model;Patients;Permeability;Pharmaceutical Preparations;Pharmacology;Pharmacology Study;Pharmacotherapy;Phase;phase I trial;Physiological;preclinical development;preclinical efficacy;preclinical safety;preclinical toxicity;Primary Brain Neoplasms;Proliferating;Property;Proteins;Proteomics;rational design;recruit;Rodent;Safety;scaffold;screening;self-renewal;small molecule;Small Ubiquitin-Related Modifier Proteins;Solubility;Specificity;standard of care;stem cells;Structure-Activity Relationship;success;synergism;Technology;temozolomide;Testing;Therapeutic;Toxic effect;Toxicology;Treatment Efficacy;tumorigenesis;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;United States National Institutes of Health;Western Blotting;Xenograft procedure

PROJECT_TITLE: Development of BBB-permeable SUMO1 small molecule degraders for glioblastoma therapy.

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Brain Disorders;Immunotherapy;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Wound Healing and Care

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Our published and preliminary data have shown for the first time that purified B lymphocytes from blood or spleen delivered within 6 hours at the site of a contusion traumatic brain injury (TBI) significantly reduced learning and memory deficits, and reduced lesion volume, gliosis, and microglial activation. The present proposal aims to define the cellular and molecular mechanisms of B cell-mediated neuroprotection after this type of injury, ultimately positioning this novel cell-based therapy for clinical use in the context of contusion TBI. Since purified mature B cells can be readily accessed from peripheral blood in donors, without pre-treatment, the long-term benefits of this research would include establishing a rapid, minimally-manipulated B cell therapy that could be given to patients to improve outcome after TBI.

PI_NAMEs: SIRBULESCU, RUXANDRA F (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: acute wound;Address;Adopted;Affect;Anti-Inflammatory Agents;Antibodies;Antibody Formation;Antigen-Presenting Cells;Apoptosis;Axon;axonal degeneration;B cell therapy;B-Cell Antigen Receptor;B-Lymphocytes;Behavioral Paradigm;Biological Response Modifiers;Blood;Brain;Brain Injuries;brain parenchyma;Bromodeoxyuridine;CD19 gene;Cell Communication;Cell Death;Cell Differentiation process;cell growth;Cell Proliferation;Cell Therapy;Cells;Cellular immunotherapy;Central Nervous System;chronic wound;Clinical;clinical development;conditional knockout;controlled cortical impact;Contusions;cost effective;cytokine;Data;Demyelinations;efficacy testing;Environment;Flow Cytometry;follow-up;Foundations;functional restoration;Gene Expression Profile;glial activation;Gliosis;grasp;healing;Histology;Histopathology;Homeostasis;Hour;Housekeeping;humoral immunity deficiency;Immune;immune cell infiltrate;Immune system;immunoregulation;Immunotherapy;improved outcome;In Situ;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Injections;injured;Injury;Interleukin-10;Interleukin-4;Investigation;Knock-out;knockout gene;Knockout Mice;Learning;Lesion;Macrophage;Maps;Mature B-Lymphocyte;Measures;Mediating;Medical;Memory impairment;Microglia;Modeling;Molecular;monocyte;motor learning;mouse model;Mus;Myocardial Infarction;Neurodegenerative Disorders;neuronal survival;neuroprotection;neutrophil;novel;Oxidative Stress;pathogen;Pathway interactions;Patients;Pattern;peripheral blood;Phenotype;Physiologic pulse;Plasma Cells;Play;Population;Positioning Attribute;pre-clinical;Production;protective effect;protein expression;Proteomics;Publishing;receptor;Regulation;repaired;Research;response;response to injury;Role;Sampling;sensor;Signal Transduction;Site;Skin wound healing;Sorting;Spleen;stroke model;Symptoms;Therapeutic;Time;Tissues;Toll-Like Receptor Pathway;Toll-like receptors;transcriptome sequencing;Transforming Growth Factor beta;Traumatic Brain Injury;wound;wound healing;Wound models

PROJECT_TITLE: Neuroprotective B Cell Immunotherapy for Contusion Traumatic Brain Injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project narrative In this proposal, we shall explore a new unique family of copper containing anti-oxidant proteins, including the superoxide dismutase enzymes needed for pathogenesis of Candida albicans, the most prevalent of human fungal pathogens.

PI_NAMEs: CULOTTA, VALERIA C (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Active Sites;Aerobic;Animals;antioxidant enzyme;Antioxidants;Binding;Biochemical;Biology;Biophysics;Candida albicans;Cells;Cellular biology;cofactor;Copper;Cu-Superoxide Dismutase;Cuprozinc Superoxide Dismutase;design;Enzymes;Equilibrium;Eukaryota;extracellular;Family;fungus;Genes;Goals;Growth;Human;Hydrogen Peroxide;Metabolism;metallicity;Metals;Modeling;NADPH Oxidase;Natural Products;Nature;Organism;Oxidation-Reduction;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Pathway interactions;polypeptide;Proteins;Reactive Oxygen Species;Regenerative capacity;rho GTP-Binding Proteins;Signal Transduction;Signaling Molecule;Site;Solvents;Source;structural biology;Superoxide Dismutase;Superoxides;System;Tandem Repeat Sequences;Tissues;Variant;weapons;Yeasts

PROJECT_TITLE: Cuproproteins for Redox Biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Public Health Relevance: Conformational dynamics plays a fundamental role in gene regulation by many regulatory non-coding RNAs, such as riboswitches that are widely found in bacteria, including some important pathogenic bacteria. The proposed structural, dynamic, and functional studies of co- transcriptional regulation of riboswitches will bring new insights into the molecular understanding of their regulatory mechanisms, hence providing basis for developing riboswitch-based regulatory tools for synthetic biology and riboswitch-targeted antimicrobial therapeutics.

PI_NAMEs: ZHANG, QI  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 3-Dimensional;Adopted;Anabolism;Antibiotic Resistance;Antibiotics;antimicrobial;aptamer;Bacillus cereus;Bacteria;Binding;Biochemical;Biological Assay;Biological Process;Cells;Chemicals;Code;Communication;Complex;Computer Models;conformational conversion;Coupled;Deltaproteobacteria;Development;Engineering;Flavin Mononucleotide;Fluorides;Funding;Gene Expression Regulation;Genetic Transcription;Goals;Individual;insight;Kinetics;Ligand Binding;Ligands;Maps;Mediating;Modeling;Molecular;Molecular Conformation;Mutagenesis;Mutation;novel;pathogenic bacteria;Pathway interactions;Play;Process;Property;protein expression;public health relevance;Regulation;Regulator Genes;Research;Resolution;Riboflavin;Ribosomes;RNA;RNA Conformation;Role;small molecule;Spectrum Analysis;Structural Models;Structure;synthetic biology;System;Techniques;technological innovation;Testing;Therapeutic;Thermodynamics;Time;tool;Transcriptional Activation;Transcriptional Regulation;Translational Regulation;Translations;Untranslated RNA;Work

PROJECT_TITLE: Riboswitch Dynamics at Atomic Resolution

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Social Determinants of Health

ORG_CITY: Columbus

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The project "The economic and social impact of COVID-19 mitigation policies: A cross- country analysis of macro events" will explore the economic and social effects the mitigation policies and information environment that COVID-19 spawned. We will link the policies to individual panel data and exploit the substantial temporal and geographic variation, in and across countries, in non-pharmacological intervention policies induced by the COVID-19 disease.

PI_NAMEs: LILLARD, DEAN R (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: 2019-nCoV;Behavior;Case Fatality Rates;Cessation of life;Characteristics;China;Code;Communities;Coronavirus;Country;Coupled;COVID-19;COVID-19 impact;COVID-19 pandemic;Data;Death Rate;Demography;Diagnosis;discount;Disease;economic impact;Economics;Elderly;Employment;Environment;epidemiological model;Event;experience;Family member;Federal Government;geographic difference;Government;Herd Immunity;Heterogeneity;Hospitalization;Household;Human;human old age (65+);Income;Individual;Industry;Italy;Life;Link;Local Government;Medical;member;Modeling;Nature;Nonpharmacologic Therapy;Occupations;Older Population;Outcome;outreach;pandemic disease;Pattern;Personal Satisfaction;Persons;Policies;Population;Protocols documentation;Records;Relaxation;Research;Research Personnel;Resource Sharing;Respondent;risk perception;Running;Sampling;SARS coronavirus;SARS-CoV-2 infection;satisfaction;Scientist;Severe Acute Respiratory Syndrome;Shapes;Shock;social;Social Impacts;Sociology;Surveys;symposium;System;Time;transmission process;trend;Uncertainty;Update;Variant

PROJECT_TITLE: The economic and social impact of COVID-19 mitigation policies: A cross-country analysis of macro events

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness

PHR: Project Narrative / Relevance Now in its 13th year, the Psychiatric Genomics Consortium is perhaps the most innovative and productive experiment in the history of psychiatry. We propose to expand the work of the PGC so we can learn key lessons about the fundamental basis of major psychiatric disorders

PI_NAMEs: BOERGLUM, ANDERS ;DAVIS, LEA K;FRANKE, BARBARA ;NEALE, BENJAMIN MICHAEL (contact);ROBINSON, ELISE B

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;Address;Affect;Alleles;base;biobank;Biological;Biology;Biotechnology;career;case control;Cells;Clinical;Collaborations;Communication;Communities;Country;Data;Diagnostic;digital media;Disease;DNA Resequencing;education resources;Educational Materials;Ensure;Epidemiology;exome;exome sequencing;experimental study;Facebook;Family;Fostering;functional genomics;Funding;Genes;Genetic;genetic architecture;genetic pedigree;Genetic Variation;Genets;Genome;genome sequencing;genome wide association study;genomic data;genomic locus;Genomics;Goals;improved;Individual;Industry;innovation;insight;Institution;instrument;Investments;Journals;Knowledge;Learning;Life;Maps;Measures;Medical;Medicine;Mendelian randomization;Mental disorders;Meta-Analysis;Methods;Mission;Modeling;Molecular;National Institute of Mental Health;Nature;Neurosciences;novel;novel therapeutics;Outcome;outreach;Paper;patient stratification;patient subsets;Patients;Phase;Phenotype;predict clinical outcome;Productivity;Psychiatric Diagnosis;psychiatric genomics;Psychiatry;rare variant;Recording of previous events;Reproducibility;Research Personnel;Resistance;Resources;Risk;Risk Factors;Science;Scientist;severe psychiatric disorder;Source;statistics;success;Symptoms;Therapeutic;therapeutic development;Time;translational potential;Twitter;Update;Variant;whole genome;Work;working group

PROJECT_TITLE: 2/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-B(02)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Regenerative Medicine

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: This proposed project focuses on a unique population of regulatory T cells that is located in skeletal muscle and regulates local repair/regeneration after acute or chronic injury. The identification of factors that promote the expansion and survival of these populations, or reparative factors that they produce, should deepen our understanding of and eventually aid our treatment of muscular dystrophies, autoimmune myositides and chronic muscle infections. There should also be applications to age-associated deficiencies in muscle mass, function and repair – a growing health problem with our aging society – as well as to battle and other severe wounds.

PI_NAMEs: MATHIS, DIANE J (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Acute;age related;Aging;Antibiotics;Autoimmune;Biological;Brain;Calcitonin Gene-Related Peptide;Cells;Chronic;Circulation;Clonal Expansion;Colon;conditional knockout;Data;Dependence;design;Disease;Event;Exercise;experimental study;Fibrosis;fighting;FOXP3 gene;Funding;GATA3 gene;Goals;Growth;gut microbiota;Health;Homeostasis;Image;Immigration;Immune response;Immune system;Impairment;Individual;Infection;Inflammatory;Inflammatory Infiltrate;inhibitor;Injury;interest;Knock-out;Knockout Mice;Leucocytic infiltrate;Lymphoid;lymphoid organ;Macrophage;mesenchymal stromal cell;microbial;Modeling;Mus;Muscle;muscle form;muscle progenitor cell;muscle regeneration;muscle repair;Muscular Dystrophies;Myocardium;Natural regeneration;Nerve;Nervous System;Nociceptors;orphan nuclear receptor ROR-gamma;pain perception;Peptide Signal Sequences;Peptides;pharmacologic;Phase;Phenotype;Play;Population;Process;Production;Proliferating;regenerative;Regulatory T-Lymphocyte;repaired;Reporting;Role;sarcopenia;Signal Transduction;single-cell RNA sequencing;Skeletal Muscle;Skin;Societies;Stromal Cells;System;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Therapeutic;Time;tissue regeneration;tissue repair;Tissues;transcriptome;transcriptomics;Waxes;wound;wound healing;Zebrafish

PROJECT_TITLE: Muscle Tregs in health and disease

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Regenerative Medicine;Wound Healing and Care

ORG_CITY: DETROIT

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: The objective of this project is to fill the knowledge gap of how an FDA-approved oral formula of small molecules, tRES+HESP, can enhance the new blood vessel formation in treating non- healing wounds in diabetic patients as a topical application. We will evaluate the therapeutic potential of tRES+HESP and its underlying molecular mechanisms in human vascular endothelial cells in Aim 1, and in a newly developed diabetic chronic wound animal model in Aim 2, using a combination of cell culture and animal studies (for causal mechanisms in vitro and in vivo) and cutting-edge proteomics studies (for global analysis of cell signaling & unbiased discovery). The outcome of the proposed research will determine the efficacy of topical application of this formula, tRES+HESP, in diabetic wound healing, and will unveil underlying molecular mechanisms for its beneficial effect.

PI_NAMEs: WANG, JIEMEI ;YI, ZHENGPING  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Affect;Amputation;angiogenesis;Angiogenic Factor;ANGPT1 gene;Animal Model;Animals;blood vessel development;burn wound;Cell Culture Techniques;Cell Physiology;Cell Survival;Cells;Chronic;chronic wound;Clinic;Critical Pathways;Cytoprotection;Data;db/db mouse;Dermal;Diabetes Mellitus;diabetic;Diabetic Foot Ulcer;diabetic patient;diabetic ulcer;diabetic wound healing;dietary;Drug Metabolic Detoxication;efficacy evaluation;Endothelial Cells;Enzymes;FDA approved;Gene Expression;Glucose;glycation;Glycolysis;Goals;Health;Human;Impairment;improved;In Vitro;in vivo;Knowledge;Lactoylglutathione Lyase;Literature;metabolic profile;migration;Modeling;Molecular;non-healing wounds;novel;obese person;Oral;Outcome;Overweight;Pathway interactions;Patients;Permeability;Play;Population;Proliferating;Proteins;Proteomics;Protocols documentation;Regimen;Regulation;Reporting;Research;Role;Signal Transduction;small molecule;Stress;success;Testing;Therapeutic;tissue repair;Topical application;trans-resveratrol;translational potential;traumatic wound;Treatment Protocols;Vascular Endothelial Cell;wound;wound care;wound closure;wound healing;Wound models;wound treatment

PROJECT_TITLE: Mechanistic study of Small-molecular Therapy in diabetic Wound Healing

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE We propose to leverage several research studies of persons with HIV (PWH) that measured phosphatidylethanol (PEth), a biomarker of how much alcohol someone has consumed over the past month that is found in the blood, to investigate key questions about how alcohol use affects the health of persons with HIV and how to reduce alcohol use. We will also use these data to explore other ways to measure alcohol use via common blood tests.

PI_NAMEs: HAHN, JUDITH ALISSA (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Affect;Age;Aging;Agreement;Alcohol consumption;alcohol intervention;alcohol measurement;alcohol misuse;alcohol risk;Alcohols;antiretroviral therapy;Biological Markers;Biometry;Blood;Blood Tests;carbohydrate-deficient transferrin;clinical care;cohort;Cohort Studies;Consumption;cost;Data;Data Pooling;Diagnostic;Dryness;efficacy evaluation;Ethnic Origin;experience;Failure;Future;Glucuronides;Goals;Harm Reduction;Health;HIV;indexing;Individual;Intervention;Intervention Studies;Intervention Trial;Laboratories;Measurement;Measures;Meta-Analysis;Metabolism;Modification;mortality;mortality risk;Observational Study;Outcome;Participant;Patient Self-Report;Pattern;Persons;phosphatidylethanol;Population Heterogeneity;Populations at Risk;predictive modeling;Predictive Value;Race;randomized trial;Randomized, Controlled Trials;reduced alcohol use;Regimen;Reporting;Research;Research Design;research study;Resources;Risk;sex;Social Desirability;Spottings;stem;substance use;Testing;therapy adherence;tool;Treatment Efficacy;Uncertainty;Urine;Veterans;Viral Load result;Whole Blood

PROJECT_TITLE: Biomarkers for Alcohol/HIV Research (BAHR) Study

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Despite recent advances, swallowing and reflux related aerodigestive disorders remain common especially among the elderly and continue to cause enormous health burden and human suffering including diminished quality of life, malnutrition, aspiration pneumonia, weight loss and death. In this proposal, our multi-disciplinary team will generate the necessary data for better understanding and development of novel preventative and management strategies for these devestating disorders.

PI_NAMEs: SHAKER, REZA NONE (contact)

PROGRAM_OFFICER_NAME: KLAPPROTH, JAN-MICHAEL AXEL

PROJECT_TERMS: accurate diagnosis;Age;age related;Anatomy;aspirate;Aspiration Pneumonia;Biomechanics;body position;Body Weight decreased;Bolus Infusion;Cessation of life;Clinic;clinically relevant;cost estimate;Cricoid cartilage structure;Data;Deglutition;Deglutition Disorders;Development;Devices;digital;Disease;Elderly;electric impedance;Esophagus;Event;Exhibits;Family Felidae;Fluoroscopy;Fortification;Functional disorder;Health;Human;Independent Living;Injections;Investigation;Laboratories;Larynx;Lead;Liquid substance;Malnutrition;Manometry;Methods;Modeling;Motor;multidisciplinary;neural;Neurodegenerative Disorders;novel;Patients;Penetration;Peristalsis;Persons;Pharyngeal structure;Phase;Physiological;Positioning Attribute;post stroke;pressure;prevent;Property;Quality of life;Reflex control;Reflux;Reporting;response;Rest;Risk;Secondary to;Striated Muscles;stroke patient;Testing;volunteer

PROJECT_TITLE: Deglutitive and airway protective functions of proximal/ striated muscle esophagus in health and disease

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_DEPT: ADMINISTRATION

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative. Medicaid expansion increases health care access and reduces food and housing insecurity thus improving health and providing a tool to reduce health disparities. This project links Medicaid member claims, pre-post survey data, and community-level public health data to examine how access to primary care during the first year of enrollment is modified by sociocultural, built environment, and health care domains of influence as well as whether primary care use reduces social needs one year after enrollment. Results will help state Medicaid agencies formulate policies to reduce social needs and more equitably improve health.

PI_NAMEs: SHADOWEN, HANNAH  (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: access disparities;Address;Adult;Area;Black race;built environment;care systems;Censuses;Clinic;clinical development;clinical training;cohort;Collaborations;Communities;County;Data;Data Set;Dedications;design;Enrollment;Ensure;Environment;Equity;Ethnic Origin;Evaluation;experience;Face;Faculty;Family Practice;follow-up;Food;Formulation;Health;health care availability;Health Care Costs;health data;health disparity;health equity;Health equity research;Health Personnel;Health Policy;Healthcare;Healthcare Systems;Housing;Improve Access;improved;indexing;Individual;innovation;insight;Insurance Coverage;interest;Intervention;Learning;Link;Low income;Low Income Population;Measures;Medicaid;Medicaid eligibility;Medical;Medicine;member;Mentors;Mentorship;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;Outpatients;Patients;Pattern;Pharmacy facility;Physicians;Policies;Policy Maker;poor health outcome;Population;population health;Positioning Attribute;Poverty;Primary Care;primary care visit;Public Health;public health insurance;Race;Reduce health disparities;Research;Research Methodology;Research Training;residential segregation;rurality;safety net;Scientist;secondary analysis;Shapes;skills;social;social culture;social deprivation;statistics;supported housing;Surveys;Testing;tool;Training;Universities;Urbanicity;Virginia;waiver;Work

PROJECT_TITLE: The relationship between social needs and primary care use after enrollment in Virginia’s Medicaid expansion: The influence of sociocultural and built environments

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Data Science;Drug Abuse (NIDA only);Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Substance Misuse

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: RELEVANCE TO HUMAN HEALTH Alcoholism and drug addiction are chronic diseases with limited treatment options, creating a significant legal, social, and public health burden. Historically, these and many other complex diseases have been investigated using mouse genetic approaches, but extrapolation of results from mouse studies to human populations remains a challenge. The Mouse Phenome Database is a widely used database platform that meets this challenge through sharing of well-documented mouse data and tools, that in turn enables researchers to integrate and analyze information across studies, and translate mouse results into human health relevance. The MPD therefore provides a unique platform for investigation of addiction and other complex human diseases.

PI_NAMEs: BOGUE, MOLLY A (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: addiction;Address;Alcoholism;Automation;Bioinformatics;Biology;Biomedical Research;Biometry;Chronic Disease;Communities;Complex;Complex Genetic Trait;Computational Science;Computer software;Data;Data Analyses;data integration;data integrity;data repository;Data Set;data standards;Database Management Systems;Databases;Development;Disease;diverse data;Documentation;Drug Addiction;Education;Engineering;Ensure;Evolution;experience;experimental study;FAIR principles;Funding;Genetic;genetic analysis;genetic approach;Genetic study;Genetic Variation;genome-wide analysis;genomic locus;Genomics;Goals;Health;Human;human disease;Human Genetics;Inbred Strain;insight;Institution;interoperability;Investigation;Laboratories;Legal;Letters;model organism;Modernization;Mollies;mouse genetics;Mus;Online Systems;outreach;Pharmaceutical Preparations;phenome;phenomics;Phenotype;phenotypic data;Population;Predictive Value;Protocols documentation;Public Health;public repository;repository;Reproducibility;Research;Research Personnel;Resources;response;Sample Size;science teacher;Scientific Advances and Accomplishments;Scientist;social;Software Engineering;Standardization;Study models;System;Testing;The Jackson Laboratory;tool;Training and Education;training opportunity;trait;Translating;Translational Research;Translations;usability;Variant;Visualization;Work

PROJECT_TITLE: Mouse Phenome Project

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: EY

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences;Sleep Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE The proposed research is relevant to public health because it will provide novel insights into the role of long-range inhibitory neurons in different states of cortical activity that occur during sleep and wakefulness. This research will be significant because it will clarify the mechanisms by which the firing activity of a specific type of long-range inhibitory neuron influences cortical states in health and in disease. This is relevant to the NIH mission to seek fundamental knowledge of the visual system and to use this knowledge to reduce the burden of neurological disease.

PI_NAMEs: BATISTA-BRITO, RENATA  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Affect;Animals;Area;area striata;Arousal;autism spectrum disorder;Axon;Behavioral;Brain;Brain imaging;Brain region;cell type;Cells;Cerebrum;Cognition;Communication;Data;discrimination task;Disease;Distant;Electroencephalography;extracellular;Frequencies;Gene Expression;Generations;Genetic;Health;Human;imaging modality;in vivo;inhibitory neuron;insight;Knowledge;Link;Measures;Mental Depression;Mental disorders;millimeter;Minority;Mission;Monitor;Morphology;Mus;Neocortex;neocortical;Nervous System Disorder;neuronal circuitry;Neurons;neuropsychiatric disorder;Nitric Oxide Synthase Type I;novel;operation;optogenetics;Output;Pattern;Perception;Play;Positioning Attribute;postsynaptic;preservation;presynaptic;Public Health;Pyramidal Cells;rabies viral tracing;Reptiles;Research;response;Rest;Role;Schizophrenia;Sensory;Sleep;Slow-Wave Sleep;Somatostatin;Stimulus;Testing;theories;tool;United States National Institutes of Health;Visual;visual discrimination;Visual Perception;Visual System;Visualization;Wakefulness;Work

PROJECT_TITLE: Long-range inhibitory neuron circuit organization and cortical function

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: BIOLOGY

PHR: Narrative The neuromodulator dopamine is important for normal brain function, and defects in dopamine signaling are associated with brain disorders, for example with neurodegeneration in Parkinson's Disease. We will generate precise understanding of the regulatory and signaling mechanisms of dopamine in the striatum, a brain structure essential for movement control. Our studies will provide new insight into dopamine neuron cell biology, may uncover general principles for neuromodulation, and may reveal new targets for developing treatments for neurological disorders.

PI_NAMEs: KAESER, PASCAL SIMON (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Ablation;Acetylcholine;Action Potentials;Affinity;Architecture;Axon;biomarker identification;Brain;Brain Diseases;Cells;Cellular biology;cholinergic;cholinergic neuron;Cholinergic Receptors;Code;Communication;Corpus striatum structure;Data;Defect;Diffuse;Diffusion;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;Dopamine Receptor;dopaminergic neuron;Electrophysiology (science);Endocytosis;Exocytosis;experimental study;Extracellular Space;functional plasticity;Funding;G-Protein-Coupled Receptors;Glutamates;Goals;Image;insight;Interneurons;knockout gene;Laboratories;Lead;Mediating;Membrane;meter;Midbrain structure;millisecond;Modeling;Molecular;molecular assembly/self assembly;molecular marker;Movement;Mus;nanometer;nanoscale;Nerve;Nerve Degeneration;Nervous System Disorder;Neuromodulator;neuronal cell body;Neurons;neuroregulation;neurotransmitter release;Parkinson Disease;Pathology;Pathway interactions;Phase;Positioning Attribute;presynaptic;Property;Proteins;receptor;Receptor Activation;Recycling;Regulation;Role;Signal Transduction;Site;Slice;Speed;Structure;superresolution microscopy;Synapses;Synaptic Cleft;Synaptic Transmission;System;Testing;Three-Dimensional Image;tool;trafficking;transmission process;ultra high resolution;Vesicle;voltage;Work

PROJECT_TITLE: Architecture and Function of Striatal Dopamine Signaling Machinery


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Pathological changes to glial cell structure are a hallmark of many neurodegenerative eye diseases. Our goal is to understand how such changes contribute to disease progression in glaucoma. By advancing knowledge of glial cell dysfunction during disease onset, our work will identify new ways to diagnose and treat glaucoma before irreversible vision loss occurs.

PI_NAMEs: KUO, SIDNEY P (contact)

PROGRAM_OFFICER_NAME: HENLE, STEVEN JOHN

PROJECT_TERMS: Affect;Area;Axon;Blindness;Calcium Signaling;Cell Death;Cell membrane;Cell Physiology;cell type;Cells;Cellular Morphology;Cellular Structures;Cessation of life;Chronic;Contrast Sensitivity;Coupled;Dendrites;designer receptors exclusively activated by designer drugs;Diagnosis;Disease;Disease Progression;Early identification;Electrophysiology (science);Event;excitotoxicity;experimental study;extracellular;Eye;Eye diseases;Family;fluorescence imaging;Fluorescence Microscopy;Functional disorder;Glaucoma;Gliosis;Glutamate Receptor;Glutamate Transporter;glutamatergic signaling;Glutamates;Goals;Health;high intraocular pressure;hypertensive;Image;Injections;Inner Plexiform Layer;insight;Knowledge;Label;Light;Link;Measures;Mechanics;Membrane;Microscopy;Microspheres;Modeling;Molecular;Morphology;Muller's cell;N-Methylaspartate;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurons;novel;Ocular Hypertension;Onset of illness;optical imaging;Output;patch clamp;Pathologic;Pattern;Physiologic Intraocular Pressure;Physiology;Play;Positioning Attribute;Predisposition;Preparation;pressure;Process;receptor-mediated signaling;Regulation;Research;response;Retina;Retinal Diseases;retinal ganglion cell degeneration;Retinal Ganglion Cells;retinal neuron;Risk Factors;Role;selective expression;Shapes;Signal Transduction;Site;Synapses;synaptic function;Techniques;Testing;Tissue Fixation;Tissues;Transgenic Mice;two-photon;uptake;Viral;visual stimulus;Withdrawal;Work

PROJECT_TITLE: Muller glial cell pathophysiology during glaucoma onset

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Kidney Disease;Lupus;Precision Medicine;Prevention

PHR: Project Narrative The development of urine proteomic biomarkers could shift the management strategy of lupus nephritis to prevention, potentially leading to earlier, more effective, and less toxic treatment. This R01 explores three new outcomes: 1) development of a urine biomarker panel to identify new lupus nephritis (biopsy confirmed) BEFORE proteinuria; 2) development of a urine biomarker panel to predict renal flare when tapering immunosuppression in patients with treated nephritis (and no proteinuria); and 3) leverage omic data from the SLE AMP program to identify predictors of chronic kidney disease trajectories.

PI_NAMEs: FAVA, ANDREA  (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;arm;belimumab;Biological Markers;biomarker discovery;biomarker panel;Biopsy;candidate marker;Chronic Kidney Failure;Clinical;clinical application;clinical practice;clinical remission;Clinical Trials Design;clinically significant;cohort;Creatinine;Cytoplasmic Granules;Data;Development;Diagnosis;Disease Progression;early detection biomarkers;Early Diagnosis;Early identification;Early Intervention;Fibrosis;Flare;follow-up;Future;Galectin 1;Glomerular Filtration Rate;high risk;Histologic;IL16 gene;Immunosuppression;indexing;Individual;inhibitor;Interleukin-16;Kidney;kidney biopsy;Kidney Diseases;Longitudinal cohort;Lupus;Lupus Nephritis;Machine Learning;Measures;Mediating;Medicine;mortality;Nephritis;Nephrons;neutrophil;Normal Range;Outcome;participant enrollment;Patients;predictive marker;predictive panel;Prevention;programs;Prospective cohort;Proteins;Proteinuria;Proteome;Proteomics;Protocols documentation;PRTN3 gene;renal damage;Renal function;Residual state;Risk;Sampling;Serum;Signal Transduction;standard of care;Systemic Lupus Erythematosus;Testing;Therapeutic immunosuppression;Time;TNF gene;tool;Transforming Growth Factor beta;treatment response;United States National Institutes of Health;urinary;Urine;Work

PROJECT_TITLE: Clinical applications of urine proteomics to lupus nephritis

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE As the most abundant cell type in the intestinal epithelium, enterocytes build specialized structures known as ‘brush borders’ on their surface to enable nutrient uptake from the gut lumen. Despite occupying a critical physiological interface, our understanding on how enterocytes assemble and organize brush borders, or how they coordinate their function at the tissue-scale remains unclear. This proposal will investigate mechanisms underlying the assembly and organization of apical brush borders, and on a larger scale the nutrient absorbing luminal surface of the gut; this work will generate insight on processes underlying normal gut function as well as human diseases characterized by perturbation to enterocyte structure and function.

PI_NAMEs: TYSKA, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: actin depolymerizing factor;Actins;Apical;apical membrane;Architecture;ATP phosphohydrolase;base;Binding;Biochemical;Brush Border;C-terminal;Cell Culture Techniques;Cell Line;cell motility;cell type;Cells;cellular microvillus;Cytoplasm;Cytoskeleton;Data;Defect;Dimensions;Electron Microscopy;Enterocytes;Epithelial Cells;Epithelium;Eukaryotic Cell;Exclusion;Exhibits;Filament;Fingers;Generations;Genetic;Housing;Human;human disease;Image;Impairment;in vivo;Individual;insight;Intercellular Junctions;Intermediate Filaments;Internet;intestinal epithelium;Intestines;Knockout Mice;Length;Light;light microscopy;Maps;Measures;mechanical force;Mechanics;Membrane;Microfilaments;Microscopy;Microtubules;migration;Modeling;Morphology;Motor;mouse model;Mus;Muscle;Myosin ATPase;Myosin S-2;N-terminal;non-muscle myosin;Nutrient;nutrient absorption;Organelles;Organoids;Physiological;Physiology;Positioning Attribute;Process;Property;Protein Isoforms;regenerative;Regulation;Rod;Sarcomeres;scaffold;Shapes;single-cell RNA sequencing;Small Intestines;small molecule;solute;Structure;superresolution microscopy;Surface;Tail;Testing;Tissues;uptake;Vesicle;Villus;Visualization;Work

PROJECT_TITLE: Myosin-2 function in the enterocyte terminal web

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Social Determinants of Health;Substance Misuse

ORG_CITY: DURHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Nine out of 10 adults with an addiction disorder started using by early adolescence, a developmental period defined by increased peer-centric social interactions, risk taking, and drug use. We have demonstrated the refinement/“pruning” of dopamine receptors within the brain by the primary immune cells of the brain, microglia, during adolescence in rats; this proposal will test the significance of this pruning for addiction later in life.

PI_NAMEs: BILBO, STACI D (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Acute;addiction;addiction liability;Adolescence;Adolescent;Adult;Age;Alcohol consumption;Behavior;Brain;brain cell;Cells;Cessation of life;Complement;COVID-19 pandemic;critical period;Development;developmental plasticity;Disease;Dopamine;Dopamine Receptor;Drug abuse;Drug Exposure;Drug usage;early adolescence;Eating;Excision;experience;Female;Genetic;Human;illicit drug use;Immune;Inflammatory;late life;Life;life span;male;Mediating;Membrane;Microglia;Molecular;Morphine;mouse model;neural;Neurobiology;Neurons;Nucleus Accumbens;Opioid;opioid abuse;opioid epidemic;peer;Phagocytosis;Pharmaceutical Preparations;Play;prescription opioid misuse;prevent;Rattus;receptor;Reporting;resilience;response;reward circuitry;reward processing;Rewards;Risk;Risk Taking;Rodent;Rodent Model;Role;Self Administration;sex as a biological variable;Signal Transduction;social;Social Behavior;Social Environment;Social Interaction;Social isolation;Stress;Synapses;System;Testing;twelfth grade;Tyrosine 3-Monooxygenase;Ventral Tegmental Area;Weaning;young adult

PROJECT_TITLE: Microglial pruning of dopamine receptors and opioid abuse.

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative Neuronal plasticity is how neurons change their connections with other neurons and is essential for normal brain development and function. However, plasticity also underlies addiction and is misregulated in disorders such as autism and schizophrenia. We propose to identify and study novel molecular mechanisms of neuronal plasticity, using circadian clock neurons as neurons with highly predictable plasticity.

PI_NAMEs: BLAU, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Actins;addiction;autism spectrum disorder;Brain;Cerebral hemisphere;circadian pacemaker;Cognition Disorders;Development;Disease;disorder risk;Drosophila genus;Ensure;fly;Gene Expression;Genes;Genetic;Genetic Transcription;Genomics;Goals;Guanosine Triphosphate Phosphohydrolases;Human;insight;Learning;Mammals;Mental disorders;Molecular;Morphology;Mutation;Neurobiology;Neuronal Plasticity;Neurons;novel;Pathway interactions;posttranscriptional;Probability;programs;Property;response;risk variant;Schizophrenia;Sleep;Specific qualifier value;Synapses;Testing;tool;Toy;transcription factor;Translations;Visualization;Work

PROJECT_TITLE: Molecular mechanisms of neuronal plasticity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Pediatric;Precision Medicine;Prevention;Sepsis

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: Narrative The proposed research is relevant to NIH’s mission to foster innovative research strategies and their applications as a basis for ultimately protecting and improving health. Children with septic shock face exceptionally high rates of morbidity and mortality as well as high rates of red blood cell (RBC) transfusion, which may contribute to poor outcomes. This R01 proposal seeks to provide crucial information on patient- specific and blood product-specific factors that influence transfusion-related risks to inform the design and evaluation of precision-medicine based transfusion strategies to improve outcomes in these extremely ill infants and children.

PI_NAMEs: MUSZYNSKI, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: adverse outcome;Algorithms;Biological Markers;Blood Banks;blood product;Blood specimen;Cells;Characteristics;Child;Clinical;Clinical Trials;cohort;Collection;Complex;Computerized Medical Record;Critical Illness;Critically ill children;Data;Decision Making;Decision Modeling;design;Diagnostic Reagent Kits;electronic data;Erythrocyte Transfusion;Erythrocytes;Evaluation;extracellular vesicles;Face;Fostering;Functional disorder;Future;Goals;Guidelines;Harm Reduction;Health;Heme;hemodynamics;Hemoglobin;Immune;immune function;Immunologic Tests;Immunosuppression;improved;improved outcome;indexing;Infant;Inflammation;Inflammatory;innovation;Intervention Trial;Learning;Machine Learning;machine learning method;Measures;Mediator;Methods;Mission;Modeling;Morbidity - disease rate;mortality;mortality risk;Multi-Institutional Clinical Trial;Multi-site clinical study;Multiple Organ Failure;Observational Study;Organ;Outcome;Oxygen;Patients;pediatric sepsis;personalized medicine;Phenotype;Physiological;Physiology;Plasma;precision medicine;Precision medicine trial;prevent;programs;prospective;Recommendation;Research;response;Risk;Sepsis;septic;Septic Shock;Shock;Statistical Models;support tools;Techniques;Testing;therapy design;Time;Transfusion;transfusion medicine;translational immunology;United States National Institutes of Health

PROJECT_TITLE: Transfusion and Organ Dysfunction in Pediatric Septic Shock (TROPICS) study

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: Los Angeles

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The proposed project will elucidate and model the effects of nonlinear outer-hair-cell based ampliﬁcation—whose impairment underlies the most common forms of sensorineural hearing loss—for the representation of complex sounds in the healthy cochlea. Motivated by the discrepancy between the experimental data and the common understanding of the role of the auditory periphery for central auditory mechanisms, the goal of this project is to understand the cochlear mechanisms responsible for the outstanding performance of the healthy ear in acoustically adverse situations. Results of this project will ﬁnd direct applications to improving models of hearing loss and to developing new sound processing paradigms for assistive hearing technology.

PI_NAMEs: ALTOE, ALESSANDRO  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acoustics;Affect;Anatomy;Auditory;Auditory Perception;Basilar Membrane;Behavioral;Cavia;Characteristics;Chinchilla (genus);Cochlea;Complex;Computer Models;Coupled;Coupling;Data;data modeling;Dependence;design;detector;Dimensions;direct application;Ear;Felis catus;Frequencies;Gerbils;Goals;Health;Hearing;hearing impairment;Human;human model;Impairment;improved;Laboratory Animals;Liquid substance;Location;Maps;mathematical analysis;Mathematics;Measures;Mechanics;Modeling;Mus;Noise;Non-linear Models;novel;otoacoustic emission;Outer Hair Cells;Pattern;Performance;Peripheral;Physiological;Play;Procedures;Process;Property;response;Role;role model;Self-Help Devices;Sensorineural Hearing Loss;Shapes;Signal Transduction;sound;Stimulus;Structure;Technology;Testing;three-dimensional modeling;waveguide

PROJECT_TITLE: Nonlinear wave interactions in the cochlea and their application to sound processing

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PUBLIC HEALTH RELEVANCE Mechanisms that facilitate lineage-specifying gene activation are essential for normal development. The goal of this study is to optimize and apply an innovative genome-wide approach to elucidate the functional role of a novel epigenetic mechanism in regulating lineage-specifying gene expression. Outcomes of this study may support pioneering strategies to treat developmental disorders.

PI_NAMEs: RICE, JUDD C (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Adipocytes;ATAC-seq;Binding;Biological Process;bone;Cell Line;cell type;Cells;Chromatin;chromatin remodeling;Chromatin Structure;Communities;Computer Analysis;Data Set;Development;developmental disease;Disease;Epigenetic Process;epigenetic regulation;epigenomics;Eukaryota;Event;Excision;Fatty acid glycerol esters;Future;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;genome-wide;Genomics;Goals;Health;Heterogeneity;Histone H3;histone modification;Histones;Human;human disease;human tissue;In Vitro;innovation;insight;lipid biosynthesis;Maps;Methods;Modeling;Modification;multipotent cell;Multipotent Stem Cells;Mus;Muscle Cells;Muscle Fibers;myogenesis;N-terminal;next generation sequence data;novel;Nucleosome Core Particle;Nucleosomes;osteoblast differentiation;Osteogenesis;Outcome Study;Pathway interactions;Peptide Hydrolases;Post-Translational Protein Processing;precursor cell;programs;Proteins;Proteolysis;public health relevance;recruit;Regulation;Reporting;Role;Series;Site;Specific qualifier value;stem cell model;stem cells;Structure;Tail;Testing;transcription factor;Transcriptional Activation;transcriptome sequencing;United States National Institutes of Health

PROJECT_TITLE: Advancing an Innovative NGS Approach to Discover and Investigate Histone Tail Proteolysis

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Neurosciences;Nutrition

ORG_CITY: PHILADELPHIA

ORG_NAME: MONELL CHEMICAL SENSES CENTER

ORG_STATE: PA

PHR: Project Narrative The flavor of food is largely determined by its taste features, such as salty and sour tastes that are elicited by salt and acid respectively. Abnormal oral perception of salt and acid can lead to inappropriate consumption of salt and acid, leading to many nutrition-related health concerns. Identifying taste receptors and neurons responsible for salty or sour taste perception will contribute to the design of more healthful foods and the discovery of new therapeutic interventions.

PI_NAMEs: ZHANG, YALI V (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Acids;Address;Animals;base;behavioral study;Biological Assay;Body Fluids;Brain;Cardiovascular Diseases;Confocal Microscopy;Consumption;design;Detection;Disease;Diuretics;Drosophila genus;Drosophila melanogaster;Electrophysiology (science);Equilibrium;Esthesia;Family member;feeding;fly;Food;Food Additives;food flavor;Gastrointestinal Diseases;Genetic;Glean;Glutamate Receptor;Goals;Health;hedonic;Homeostasis;Hormones;Human;Image;immunocytochemistry;Insecta;insight;Intake;interdisciplinary approach;Investigation;Ion Channel;Ions;Kidney Diseases;Knowledge;Life;Mammals;Maps;Mediating;Metabolic Diseases;Minerals;Modality;model organism;Molecular;Molecular Genetics;Mus;neural;neural circuit;neuromechanism;neuronal circuitry;Neurons;novel;novel therapeutic intervention;Nutrient;nutrition;optogenetics;Oral;Organ;patch clamp;Pattern;Perception;Phylogeny;Physiology;Process;Property;Protons;receptor;Research;response;Role;Sensory;Sodium;Sodium Chloride;Stimulus;System;Taste Buds;Taste Perception;taste system;taste transduction;Techniques;Testing;Tongue;Work

PROJECT_TITLE: Molecular Genetic Investigation of Taste Sensation

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: HENRY FORD HEALTH SYSTEM

PHR: Project Narrative Pancreatic cancer is almost universally fatal. We previously identified the DCLK1-expressing metaplastic tuft cell in metaplastic and neoplastic lesions early in disease progression where they are hypothesized to act as tumor progenitor cells, but also have a chemosensory function that they utilize to modify the fibroinflammatory response. In this proposal, novel genetic models will be employed to explore the origin and definitively determine the functions of the metaplastic tuft cell in pancreatic cancer.

PI_NAMEs: CRAWFORD, HOWARD C. (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Ablation;Acceleration;Acetylcholine;Acinar Cell;alpha-gustducin;Cancer Etiology;Cell Differentiation process;Cell Physiology;cell type;Cells;Cessation of life;checkpoint inhibition;Choline;Cholinergic Agonists;Complex;cytokine;Data;Disease;Disease Progression;Duct (organ) structure;Enterobacteria phage P1 Cre recombinase;Environment;Enzymes;Epithelial Cells;Epithelium;Event;Evolution;experimental study;G-Protein-Coupled Receptors;Genes;Genetic Models;GTP-Binding Proteins;Human;Immune;Immune response;immunoregulation;In Vitro;in vivo;inducible Cre;Inflammatory;Knock-out;KRASG12D;Lesion;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Metaplasia;Microtubules;Modeling;Molds;mouse model;Mus;Nature;Neoplasm Metastasis;Neoplasms;neoplastic;neoplastic cell;Neoplastic Cell Transformation;Neuroendocrine Cell;Neurons;novel;Organ;Organoids;Outcome;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathology;Pathway interactions;Phosphotransferases;Play;Population;preservation;Process;recombinase;release factor;response;Role;Sampling;Sensory;sensory system;Signal Transduction;stem cells;Survival Rate;System;Taste Buds;Taste Perception;Techniques;Testing;three dimensional cell culture;tissue injury;tissue repair;Tissues;tool;transdifferentiation;Transferase;tumor;tumor initiation;tumor microenvironment;tumor progression;Tumor Stem Cells;tumorigenesis;United States

PROJECT_TITLE: Metaplastic Tuft Cells in Pancreatic Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-D(02)M]


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Narrative Little is known on the regulatory pathways mediating transgenerational epigenetic inheritance. Our results provide genetic evidence for a novel pathway in mice that regulates high fat diet response in the next generation and that is governed by the E3 ligase Rlim in paternal testicular Sertoli cells. Investigating this Sertoli cell --> sperm --> offspring pathway, our research will uncover novel epigenetic mechanisms and establish our conditional Rlim KO mice as a new paradigm for transgenerational epigenetic regulation.

PI_NAMEs: BACH, INGOLF M (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Ablation;Adult;Affect;Alleles;Biological;Biological Models;blastocyst;cell type;Diet;diet-induced obesity;DNA Methylation;Dosage Compensation (Genetics);Embryo;Energy Metabolism;Epigenetic Process;epigenetic regulation;epigenetic silencing;Fathers;Female;Genes;Genetic;Genetic Models;Germ Cells;Goals;High Fat Diet;histone modification;imprint;Investigation;Knockout Mice;Link;male;Mediating;Molecular;mouse model;Mus;next generation;novel;offspring;Pathway interactions;Publishing;Regulatory Pathway;Research;response;Ring Finger Domain;sertoli cell;Signal Transduction;Small RNA;sperm cell;Spermatids;Spermatogenesis;Spermatogenic Cell;Technology;Testis;transgenerational epigenetic inheritance;transmission process;ubiquitin-protein ligase;X Chromosome;X Inactivation

PROJECT_TITLE: Transgenerational epigenetic regulation by Rlim

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Lung;Lupus;Primary Immunodeficiencies;Rare Diseases

PHR: PROJECT NARRATIVE: In this grant we are studying a genetic autoimmune disease called COPA syndrome which has similarities to systemic lupus erythematosus (SLE). Using an animal model of COPA syndrome, we are trying to understand why patients with COPA syndrome develop inflammation in their lungs, joints and kidney. We will test whether we can use new drugs called small molecule inhibitors to reverse inflammation caused by one of the proteins that is abnormally stimulated to understand whether the drugs might be beneficial in patients.

PI_NAMEs: SHUM, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Agonist;Animal Model;Animals;Antinuclear Antibodies;arthropathies;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;Autophagocytosis;autoreactive T cell;Binding;Bone Marrow;cancer therapy;CD4 Positive T Lymphocytes;Cell Maturation;Cell Physiology;Cells;central tolerance;Childhood;Chimera organism;Chronic;Clinical;COPA syndrome;cytokine;Data;Defect;Development;Disease;ds-DNA;Epithelium;Exhibits;experimental study;Genetic;genetic signature;Goals;Golgi Apparatus;Grant;Harvest;Image;Immune;Immune Complex Glomerulonephritis;immunodeficiency;Immunologics;Impairment;in vivo;Infection;Inflammation;Inflammatory Arthritis;inhibitor;insight;Interferon Type I;Interferons;Interstitial Lung Diseases;joint inflammation;Joints;Kidney;Knock-in Mouse;Lung;Lung Diseases;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Missense Mutation;Molecular;Monogenic autoimmune disease;mouse model;Mus;mutant;novel;novel therapeutics;Online Mendelian Inheritance In Man;Organ;Patients;Peptides;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacologic;Phenotype;Proteins;Pulmonary Inflammation;Role;Shapes;Signal Transduction;small molecule;small molecule inhibitor;STING agonists;Syndrome;System;Systemic infection;systemic inflammatory response;Systemic Lupus Erythematosus;T cell response;T cell therapy;T-Cell Development;T-Lymphocyte;Testing;Thymic epithelial cell;thymocyte;Thymocyte Development;Thymocyte Selection;Thymus Gland;thymus transplantation;Work

PROJECT_TITLE: Unraveling the molecular mechanisms of impaired central tolerance in COPA syndrome

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative About 90% of people with alcohol use disorder (AUD) do not receive treatment, with even lower rates among women, Black/African American individuals, and people from other under-represented groups. Care for AUD has typically focused on referrals to specialty addiction treatment programs, which have barriers to accessibility and are stigmatized, thus not widely appealing. To address this gap, this project will use a sequential, multiple assignment randomized trial (SMART) design to examine a novel virtually-delivered engagement and treatment delivery model that can be integrated in healthcare systems to substantially improve utilization and outcomes and reduce disparities in care for this chronic condition.

PI_NAMEs: BONAR, ERIN E. (contact);LIN, LEWEI ALLISON

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: adaptive intervention;addiction;Address;Administrator;Adoption;Adult;African American;African American population;alcohol abuse therapy;Alcohol consumption;alcohol use disorder;Alcohols;barrier to care;Black Populations;Black race;care delivery;care seeking;Caring;Chronic;Chronic Care;Clinic;Cognitive Therapy;Communities;Coping Skills;cost;Cost Measures;COVID-19;Data;disparity reduction;drinking;effectiveness/implementation trial;efficacious treatment;Enrollment;Ethnic Origin;evidence base;experience;Future;future implementation;Health;health care disparity;health disparity;Health Services Accessibility;Health system;Healthcare Systems;Heavy Drinking;hybrid type 1 design;implementation facilitators;Improve Access;improved;improved outcome;Individual;Infrastructure;innovation;Intervention;Interview;Latinx;Life;Location;Measures;Mediator;medical specialties;Mental Health;Modeling;Motivation;motivational enhancement therapy;novel;opioid misuse;Outcome;outcome disparities;patient engagement;patient population;patient portal;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Phase;Phototherapy;Population;Population Heterogeneity;prevent;Psychotherapy;Public Health;Race;Randomized;Readiness;recruit;Reduce health disparities;reduced alcohol use;Resource Allocation;Resources;Risk Factors;Sampling;Sequential Multiple Assignment Randomized Trial;sex;social stigma;Stigmatization;substance use;suicidal risk;System;telehealth;Telephone;telephone session;Testing;theories;Therapeutic;treatment disparity;treatment program;trial design;Underrepresented Populations;video session;virtual;virtual delivery;virtual healthcare;Woman;Women's Group;Work

PROJECT_TITLE: Leveraging virtual care strategies to improve access and treatment for individuals with alcohol use disorders


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: 7. Project Summary/Abstract Girls and women are diagnosed with autism spectrum disorder (ASD) much less frequently than males and females have been under-studied in autism research. The overarching goal of this research program is to rectify the historical underrepresentation of females in ASD research by evaluating a large, longitudinal cohort of girls from early to middle childhood. As in so many other areas of medicine, the optimal treatment of girls and women with ASD will only emerge when sex-related autism attributes and problems are adequately understood.

PI_NAMEs: NORDAHL, CHRISTINE WU (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: 12 year old;6 year old;Address;Age;Amygdaloid structure;Area;Attention deficit hyperactivity disorder;Attenuated;attenuation;autism biomarker;autism spectrum disorder;autism symptoms;autistic;Behavioral;behavioral phenotyping;boys;Brain;Brain region;Caring;cohort;Data;Detection;Development;Diagnosis;Diagnostic;Disease;disorder risk;early childhood;emotion dysregulation;emotion regulation;Emotional;Enrollment;ethnic minority population;Etiology;Exhibits;externalizing behavior;Female;Feminization;Gender;General Population;girls;Goals;Hyperactivity;imaging study;Impulsivity;inattention;individuals with autism spectrum disorder;insight;Knowledge;Lead;life span;Literature;Longitudinal cohort;Longitudinal Studies;male;Masculine;Medicine;middle childhood;Modeling;Motor;neural;neuroimaging;optimal treatments;outcome prediction;Participant;Pattern;peer;phenome;Prevalence;programs;protective effect;Protocols documentation;Psychopathology;racial minority population;recruit;repetitive behavior;Research;Risk Factors;Sampling;Sampling Studies;Self-Injurious Behavior;Sensory;serial imaging;sex;Sex Differences;Strategic Planning;Symptoms;System;Testing;Theoretical model;theories;Time;United States Dept. of Health and Human Services;United States National Institutes of Health;Woman;women's diagnosis;Women's Health

PROJECT_TITLE: Neural and developmental trajectories of females with autism spectrum disorder

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Endocannabinoid System Research;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Prescription Drug Misuse;Substance Misuse

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Project Narrative  Elevated stress is known to enhance risk for opioid use disorder (OUD), a significant problem given the broad use of opioid analgesics in both acute and chronic pain management. This project will test an innovative model in which low endogenous opioid (EO) and endocannabinoid (EC) activity associated with elevated stress both contribute to increased OUD risk via their association with heightened reinforcing effects of opioids (e.g., drug liking). Results will provide important new mechanistic understanding of how stress increases OUD risk, and may identify a novel and clinically-pragmatic marker of risk-enhancing differential opioid responding.

PI_NAMEs: BRUEHL, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: 2-arachidonylglycerol;Absence of pain sensation;Acute pain management;Address;Algorithms;Analgesics;Anxiety;Back Pain;Benefits and Risks;biological adaptation to stress;Cardiovascular system;Chronic low back pain;chronic pain management;chronic pain patient;Clinical;clinically relevant;Crossover Design;Data;design;Development;diaries;disorder risk;Dose;Double-Blind Method;Drug Combinations;Electronics;Elements;Endocannabinoids;endogenous cannabinoid system;endogenous opioids;Equilibrium;experience;Exposure to;Funding;Goals;heart rate variability;Iatrogenesis;Impairment;indexing;Individual;individual patient;innovation;Knowledge;Laboratories;Link;Literature;Low Back Pain;Measures;Mediating;Medicine;Mental Depression;Modeling;Morphine;Naloxone;negative affect;non-drug;novel;Operative Surgical Procedures;Opioid;Opioid agonist;Opioid Analgesics;Opioid Antagonist;opioid epidemic;opioid misuse;opioid therapy;opioid use;opioid use disorder;Oral;Outcome Study;Oxycodone;Pain;Pain intensity;Pain management;Pain Measurement;pain patient;pain relief;Pathway interactions;Patients;Pattern;perceived stress;Pharmaceutical Preparations;Physiological;Placebo Control;Placebos;Plasma;Play;Postoperative Pain;Postoperative Period;precision medicine;prescription opioid;Property;Psychological reinforcement;psychosocial;Psychosocial Stress;Randomized;response;Rest;Risk;Risk Marker;risk prediction;Role;sex;Standardization;Stimulus;Stress;stressor;System;Testing;Time;Weight;Work

PROJECT_TITLE: Stress and Opioid Misuse Risk:  The Role of Endogenous Opioid and Endocannabinoid Mechanisms

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Aging;Genetics;Human Genome;Lung;Pulmonary Fibrosis;Rare Diseases;Regenerative Medicine

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: NARRATIVE Idiopathic Pulmonary Fibrosis (IPF) is a chronic, fatal disease of aging with currently limited therapeutic options. This proposal is designed to study the hypothesis that dysfunction of the pulmonary vasculature plays a critical role in the progression of lung fibrosis. Experiments of this grant will investigate the contribution of molecular abnormalities we have discovered in the lung vasculature toward our long term goal of identifying novel targets for the treatment of IPF.

PI_NAMEs: LIGRESTI, GIOVANNI  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Ablation;Address;aged;Aging;aging related;aging related disease;angiogenesis;ATAC-seq;Attenuated;Binding;Biochemical;Bleomycin;Blood capillaries;Blood Vessels;Capillary Endothelial Cell;cell age;Cell Death;cell regeneration;ChIP-seq;Chromatin;Chronic;Coculture Techniques;Collagen;conditional knockout;Coupled;Data;deep sequencing;defined contribution;design;Deterioration;Disease;Disease Progression;Endothelial Cells;endothelial dysfunction;endothelial stem cell;Endothelium;enhancer binding protein;Enhancers;Epigenetic Process;Exhibits;experimental study;Fibroblasts;Fibrosis;Foundations;Functional disorder;Gene Expression;gene function;gene repair;Gene Silencing;Genes;Genetic;genetic signature;Genetic Transcription;genome-wide;Goals;Grant;Histologic;Histones;Homeostasis;Human;human model;Hypoxia;idiopathic pulmonary fibrosis;Immunohistochemistry;Impairment;In Vitro;in vivo Model;Inflammation;Inflammatory;Inflammatory Response;inhibitor;injured;Knowledge;Laboratories;Link;LoxP-flanked allele;Lung;lung injury;lung repair;Mediating;Mediator;Methods;Molecular;Molecular Abnormality;multiple omics;Mus;Natural Immunity;NF-kappa B;novel;old mice;overexpression;paracrine;Pathway interactions;Patients;pharmacologic;Phase;Phenotype;Play;pro-aging;Production;progenitor;Pulmonary Fibrosis;repaired;Reporter;Resolution;response to injury;Role;senescence;Signal Transduction;single-cell RNA sequencing;STAT1 gene;System;Testing;Therapeutic;transcription factor;transcriptome sequencing;Transgenic Mice;vascular abnormality;Vascular Diseases;vascular endothelial dysfunction;vascular inflammation;Vascular Permeabilities;Vascular remodeling

PROJECT_TITLE: Targeting vascular dysfunction to promote lung repair and fibrosis resolution

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

PHR: Project Narrative There is a shortage of researchers with the high levels of interdisciplinary skills needed to make progress in understanding the etiology and improving clinical treatment of alcohol use disorder (AUD), a major public health problem. The objective of this training grant is to educate the next generation of researchers focused on i) elucidating the risk factors for and outcomes of problem alcohol use, ii) understanding the behavioral and molecular causes and consequences of problem alcohol use, and iii) contributing to the translation of these basic findings into improvements in both treatment and prevention of AUD. The training in this program aims to educate an interdisciplinary diverse work force of researchers with a solid knowledge of multiple relevant areas, including genetics, behavior, neurobiology, data science and clinical treatment who will be prepared to have an impact on the health of millions of individuals affected by AUD.

PI_NAMEs: MILES, MICHAEL F (contact);RILEY, BRIEN P

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TITLE: Cross-Species Multidisciplinary Training in Alcohol Research


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative  Impaired astrocyte coupling is associated with epilepsy, but there is no consensus on whether reduced coupling promotes or counteracts abnormal neuronal activity, which precedes seizures. Targeting astrocytic Cx43 might be an option, but the first step towards therapy is determining when reduced coupling is adaptive and when it is maladaptive. This proposal uses new tools and technology to determine if the timing and duration of reduced astrocyte coupling may determine if seizures are promoted or counteracted, and will identify critical upstream signaling causing reduced astrocyte coupling as a foundation for future therapeutic targeting.

PI_NAMEs: ROBEL, STEFANIE  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: acquired epilepsy;Affect;anti-epileptic agents;Astrocytes;Biology;Cells;Chemicals;Chronic;Connexin 43;Connexins;Consensus;Coupling;Data;Development;Disease;Drug Targeting;Electroencephalography;Electrophysiology (science);Epilepsy;Foundations;Functional disorder;Future;Gap Junctions;Impairment;In Situ;in vivo;Induced Neurons;Intractable Epilepsy;Knock-in Mouse;Knockout Mice;Measurement;Measures;mild traumatic brain injury;mimetics;Modeling;Monitor;mouse model;Mus;mutant;Mutate;Mutation;Neurologic;Neurons;Pathology;Patients;Persons;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiology;Positioning Attribute;Post-Translational Protein Processing;prevent;Process;Proteins;Regulation;research and development;Seizures;Serine;Shapes;Signal Pathway;Signal Transduction;Silicon;Techniques;Technology;Testing;therapeutic target;Time;tool;Traumatic Brain Injury;Viral;Virus;Western Blotting

PROJECT_TITLE: Dynamic temporal regulation of astrocyte coupling to shape neuronal activity during acquired epilepsy development

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Microbiome;Neurosciences;Opioids;Pediatric;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Adolescence is a sensitive period for the development of addiction. With many physical and emotional changes occurring during this time of life, it is crucial to identify the underlying factors that affect adolescents’ enhanced vulnerability. Building upon preliminary data that suggests adolescents are more sensitive to the behavioral consequences of gut microbiome manipulation, this proposal will examine the contribution of gut-derived metabolites to adolescent opioid self-administration and epigenetic chromatin alterations in prefrontal cortex.

PI_NAMEs: HOFFORD, REBECCA  (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Acceleration;addiction;Adolescence;Adolescent;Adult;Adverse event;Affect;Animals;Antibiotics;anxiety-like behavior;Architecture;Area;Back;Bacteria;Behavior;Behavioral;behavioral response;biological adaptation to stress;blood-brain barrier crossing;Brain;Brain region;ChIP-seq;Chromatin;chromatin immunoprecipitation;chromatin modification;Cocaine;cocaine reward;Communication;conditioned place preference;critical developmental period;Data;Development;DNA Binding;drinking water;Drug Modulation;drug of abuse;drug reward;Drug usage;Emotional;Epigenetic Process;epigenetic regulation;Essential Drugs;experimental study;Exposure to;fatty acid supplementation;Female Adolescents;fentanyl self-administration;Fiber;Gene Expression;Genes;Genetic Transcription;gut bacteria;gut microbiome;gut-brain axis;Histone Acetylation;histone acetyltransferase;Histone Deacetylase Inhibitor;histone modification;Histones;hypothalamic-pituitary-adrenal axis;Inflammation;insight;Intake;knock-down;Lesion;Life;Link;Male Adolescents;Measures;Medial;Mental disorders;mesolimbic system;Methods;microbiome;Modeling;Molecular;Morphine;Motivation;Mus;myelination;Ontology;Opioid;Pathologic;Pathway interactions;Pattern;Peripheral;Pharmaceutical Preparations;Physiological;Post-Translational Protein Processing;Predisposition;preference;Prefrontal Cortex;prevent;Production;Psychological reinforcement;Rattus;response;Rewards;Risk Factors;RNA;Role;Route;Self Administration;sex;Site;Substance Use Disorder;Supplementation;synaptic pruning;System;systemic inflammatory response;Testing;Time;transcriptomic profiling;Volatile Fatty Acids;Work

PROJECT_TITLE: Defining the role of short-chain fatty acids in adolescent opioid reinforcement and epigenetic regulation


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Retinal waves are highly correlated spontaneous firing patterns detected in the developing retina prior to maturation of visual responses, and they provide a critical source of activity to drive the refinement of connections throughout the developing visual system. Retinal waves are a robust phenomenon detected in many vertebrate species, and they persist through the changing circuits of the developing retina. Our work will determine the cellular and synaptic basis of these waves with the goal of understanding their spatiotemporal features that are critical for development of visual circuits. Moreover, we will determine the relative contribution of waves and light-activation of intrinsically photosensitive retinal ganglion cells in the regulation of dopamine levels, a neuromodulator critical for development of the retina and surrounding tissues. This work with will contribute to a detailed understanding of the organizing principles that govern the normal development of retinal circuits, contributing to our understanding the origin of some neurological birth defects.

PI_NAMEs: FELLER, MARLA  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Action Potentials;Address;Adult;Age;Amacrine Cells;antagonist;Birth;Brain;Calcium;cell type;cholinergic;Congenital Abnormality;Coupling;design;Development;Developmental Process;Dopamine;Elements;Embryo;Excitatory Amino Acid Antagonists;Exhibits;Exposure to;Eye;Fire - disasters;Fluorescence;Functional Imaging;Ganglion Cell Layer;Gap Junctions;gene network;Generations;Genetic;Glutamates;Goals;Image;imaging modality;innovative technologies;Interneurons;Knockout Mice;Light;Measures;Mediating;melanopsin;Methods;Microscope;millisecond;Motion;Mus;nanosensors;neural;Neurologic;Neuromodulator;Neurophysiology - biologic function;Nicotinic Receptors;Nose;novel;optic flow;Optics;Pattern;pharmacologic;Pharmacology;Phase;Photic Stimulation;Photoreceptors;Physiological;Play;Polymers;postnatal;Property;Regulation;Reporting;response;Retina;Retinal Ganglion Cells;retinal neuron;Role;Scanning;Shapes;Signal Transduction;single walled carbon nanotube;single-cell RNA sequencing;Site;Source;spatiotemporal;starburst amacrine cell;superior colliculus Corpora quadrigemina;Synapses;Synaptic Transmission;System;Testing;Thalamic structure;Time;Tissues;Travel;two-photon;Vision;vision development;Visual;visual map;Visual System;Work

PROJECT_TITLE: The Function of Neural Activity in Developing Retina

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: The University of Washington Practice-Based Suicide Prevention Research Center will improve suicide care in outpatient medical settings through enhancing therapeutic alliance and increased self-efficacy of providers, patients and families to manage suicide risk. The Center's approach to improving outcomes across the suicide care pathway from identification of suicide risk through assessment to decision making and risk management, crisis response, treatment of suicidality, and long-term surveillance and follow-up is consistent with the recommendations of the Joint Commission, Zero Suicide, National Action Alliance for Suicide Prevention, and the Surgeon General as well as the Biden Administration's 2021 proclamation on mental health. Over the five year time frame, the team will conduct one full size optimization trial, three human centered design exploratory studies, and eight pilot studies co-designing interventions with health care providers, patients, and families to make coordinated improvements across the suicide care pathway.

PI_NAMEs: COMTOIS, KATHERINE ANNE (contact)

PROGRAM_OFFICER_NAME: FREED, MICHAEL C

PROJECT_TERMS: Accident and Emergency department;Address;Adolescent and Young Adult;Advocate;Affect;Awareness;behavioral health;Behavioral Sciences;Bioinformatics;Caring;Childhood;Clinic;Clinical;clinical decision support;clinically actionable;Collaborations;collaborative care;Common Data Element;Communication;Consultations;Crisis Intervention;Data;data repository;Decision Making;design;Detection;Diagnosis;Discipline;Ecological momentary assessment;Ecosystem;Electronic Health Record;Emergency department visit;Environment;Evaluation;evidence base;experience;Familiarity;Family;Family Practice;Feeling suicidal;follow-up;Fright;Funding;Goals;Grant;health care settings;Health Personnel;Healthcare;Healthcare Systems;high risk;human centered design;implementation intervention;improved;improved outcome;Informatics;Information Technology;innovation;Intervention;Joints;Longterm Follow-up;Medical;Medical Education;medical schools;medical specialties;Mental Depression;Mental Health;Mental Health Services;Mentors;Methods;model design;Modeling;Observational Study;older adult;Outcome;Outpatients;Pathway interactions;Patients;Pediatric Hospitals;Pediatrics;Phase;Pilot Projects;point of care;Policies;prevent;Prevention Research;preventive intervention;primary care clinic;primary care provider;Process;programs;Provider;Psychiatry;psychologic;Recommendation;Recovery;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response;Risk;Risk Assessment;Risk Management;Running;Safety;safety assessment;Science;Scientific Inquiry;Self Efficacy;Services;Source;Specialist;suicidal;suicidal adolescent;suicidal behavior;suicidal patient;suicidal risk;Suicide;Suicide attempt;Suicide prevention;support tools;Surgeon;System;Technology;Therapeutic;therapy design;Time;tool;Training;translational health science;treatment optimization;Universities;usability;Vision;Visit;Wait Time;Washington;Work;young adult

PROJECT_TITLE: Suicide Care Research Center


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Suicide;Suicide Prevention

PROJECT_TERMS: Acceleration;Adolescent and Young Adult;Alaska Native;American Indians;care systems;Caring;Child health care;Childhood;Clinical;Collaborations;Communication;Communities;Consultations;design;Development;Discipline;Dissemination and Implementation;District of Columbia;Documentation;Ecosystem;Education;Evaluation;Evidence based practice;Faculty;Family;Family Practice;Funding;General Population;Goals;Health Personnel;Health Services;Health Services Research;Health system;human centered design;improved;improved outcome;Informatics;Infrastructure;innovation;Institution;Insurance;Interdisciplinary Study;Intervention;Lived experience;Medical;Medicine;meetings;Mental Health;Mentors;Mentorship;Methods;Military Personnel;Mission;multidisciplinary;novel;operation;Outcome;Outpatients;Pathway interactions;Patients;Persons;Phase;Physicians;Play;Policies;Policy Maker;Prevention Research;programs;Provider;Quality of Care;Research;Research Methodology;Research Personnel;Resources;Role;Science;Self Efficacy;Site;Specialist;Structure;Substance Use Disorder;suicidal;suicidal adolescent;suicidal patient;suicidal risk;Suicide;Suicide prevention;System;Talents;Therapeutic;Training;United States Substance Abuse and Mental Health Services Administration;Universities;usability;Voice;Washington;web site;Work

PROJECT_TITLE: Administrative Core


ORG_CITY: SAN DIEGO

ORG_NAME: SCINTILLON INSTITUTE FOR PHOTOBIOLOGY

PHR: PROJECT NARRATIVE  As a novel approach to the treatment of HIV, this proposal seeks to provide a solution to eventually eliminate the pool of cells harboring latent virus. We will express surface-bound and soluble broadly- neutralizing antibodies targeting HIV that are highly effective against a diverse range of HIV strains. As the surface-bound antibodies recognize viral proteins on infected cells, this recognition will lead to its killing, while soluble antibodies neutralize free virus.

PI_NAMEs: LAWSON, BRIAN  (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Address;Adverse event;Affinity;Anti-Retroviral Agents;Antibodies;Antigens;antiretroviral therapy;Autologous;Binding;Binding Sites;Biological Assay;CD8-Positive T-Lymphocytes;cell killing;Cell Line;Cells;cellular transduction;Chemicals;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;combat;design;Disease Progression;engineered T cells;Evaluation;Future;Generations;Goals;HIV;HIV Infections;Human;humanized mouse;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;in vivo evaluation;Individual;Infection;innovation;insight;latent HIV reservoir;Link;Membrane;Methods;Modality;Modeling;mouse model;Mus;Nature;neutralizing antibody;nonhuman primate;novel;novel strategies;pathogen;Patients;Process;Productivity;prophylactic;Proviruses;Route;Scanning;Serum;Signal Transduction;simian human immunodeficiency virus;Surface;synergism;T-Lymphocyte;Testing;Therapeutic;Toxic effect;vector;Viral;Viral Load result;Viral Proteins;Viral reservoir;virtual;Virus;Virus Latency

PROJECT_TITLE: CAR T CELLS ENGINEERED TO KILL HIV-INFECTED CELLS WHILE SECRETING BROADLY NEUTRALIZING ANTIBODIES

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Relevance: Project summary: Relevance to public health. As Type II Diabetes Mellitus rates continue to reach epidemic proportions, driving health and economic costs higher, the need to find safe, effective, and economically achievable therapies for the treatment of this disease is ever increasing. For this reason, much attention has been devoted to investigating pharmacological drugs based on the hormone GLP-1 for diabetes treatment, as it lowers blood glucose concentrations. Unfortunately, nausea and vomiting are the major side effects of all GLP-1-based drugs on the market, with ~25% of patients unable to tolerate effective doses. Novel research proposed here fully analyzes the effects of chemical attachment of vitamin B12 with an FDA approved GLP-1 based drug, the result of which is the complete elimination of all nausea and vomiting side effects, but retention of the desired blood glucose lowering profile – in essence creating a new second generation of improved GLP-1 therapeutics for diabetes treatment, which improves patient quality of life and expands the population that can benefit from such important therapies.

PI_NAMEs: DE JONGHE, BART C;DOYLE, ROBERT P;HAYES, MATTHEW R (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acute;Agonist;Amaze;analog;Anatomy;Animal Model;Animals;Attention;Automobile Driving;Behavior;Behavioral;Beta Cell;Binding;Binding Proteins;Biological Assay;Blood;Blood Glucose;Body Weight;Body Weight decreased;Brain;Brain Stem;Cachexia;Carrier Proteins;Cell Line;Central Nervous System;Chemicals;Chronic;Clinical;cobinamide;comorbidity;Complex;Cystic Fibrosis;Data;design;diabetes management;Diabetes Mellitus;Diagnosis;diet-induced obesity;Disease;Dorsal;Dose;Drug Kinetics;Eating;Economic Burden;economic cost;Emetics;Epidemic;euglycemia;Event;exenatide;experience;experimental study;Family;FDA approved;Gastric Emptying;GCG gene;Generations;GLP-I receptor;Glucagon;glucagon-like peptide 1;Glucose tolerance test;glycemic control;Health Care Costs;HIV;Hormones;Human;human model;Hyperglycemia;Hypoglycemia;Hypothalamic structure;improved;In Vitro;in vivo evaluation;Incidence;incretin hormone;inhibitor;innovation;Insulin;insulin secretion;Intake;Intestines;Intracellular Transport;Intrinsic factor;Kaolin;Life;Ligands;Malaise;Malignant Neoplasms;Mammals;Marketing;Mediating;Mediator;Medical;meter;Modeling;mouse model;Mus;Nausea;Nausea and Vomiting;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Outcome;Pancreas;Patient Compliance;Patients;Pattern;Penetrance;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacologic Substance;Pharmacopoeias;Pharmacotherapy;Physiological;Population;pre-clinical;pre-clinical assessment;Prognosis;Public Health;Publishing;Quality of life;Rattus;reduced food intake;Reporting;Research;Rodent Model;Role;Shrews;Sick Role;side effect;Site;Structure of beta Cell of islet;subcutaneous;Testing;Therapeutic;Therapeutic Effect;Thinness;Tissues;Transcobalamins;United States;Vagus nerve structure;virtual;Vitamin B 12;Vitamins;Vomiting

PROJECT_TITLE: Second generation GLP-1 agonists without nausea/emesis side effects

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Dissemination and Implementation Research;Lung

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Chronic Obstructive Pulmonary Disease (COPD) affects more than 16 million US adults, many of whom experience high rates of acute care revisits after initial COPD hospitalizations due to transitions of care (TOC) failures. My current NHLBI R01 aims to address gaps in effectiveness and implementation of COPD TOC programs by testing COPD TOC intervention bundles across 20 diverse US hospitals, utilizing rigorous implementation science (IS) and human-centered design (HCD) methods. This K24 will allow me to work with my team of mentees to address methodology gaps by developing, testing, and disseminating two innovative tools, including the "CHIMERA" crosswalk, which will optimize qualitative data collection to inform intervention design, and the "SMART COPD" framework, which will standardize data collection and reporting metrics across COPD TOC programs and allow for inter-program comparisons.

PI_NAMEs: PRESS, VALERIE G (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Accident and Emergency department;acute care;Address;Adult;Affect;Asthma;care delivery;care outcomes;career;Caring;Chimera organism;Chronic Disease;Chronic Obstructive Pulmonary Disease;Cluster randomized trial;Collaborations;comparative;concept mapping;Consolidated Framework for Implementation Research;Data;data acquisition;Data Collection;data harmonization;Data Reporting;data standards;design;Development;dissemination strategy;Education;Effectiveness;Evaluation;evidence base;experience;Failure;Foundations;health care delivery;Hospital Societies;Hospitalization;Hospitals;human centered design;Hybrids;implementation context;implementation framework;implementation intervention;implementation science;improved;improved outcome;Infrastructure;innovation;Intervention;Lead;Literature;Logic;Medicine;Mentors;Methodology;Methods;Midcareer Investigator Award in Patient-Oriented Research;Modeling;mortality;Names;National Heart, Lung, and Blood Institute;novel;Outcome;patient oriented research;Patient-Focused Outcomes;Patients;Peer Review;Persons;Pharmaceutical Preparations;post implementation;Process;Program Evaluation;Program Sustainability;programs;prospective;Publications;pulmonary function decline;Qualitative Methods;Reporting;Research;Research Personnel;Research Project Grants;respiratory;Review Literature;Site;Standardization;Testing;therapy design;Time;tool;Training;trial comparing;virtual;Visit;Walking;Work

PROJECT_TITLE: SMART POR: Supporting and Mentoring Across Respiratory Topics in Patient Oriented Research

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Genetics;Neurosciences;Pediatric

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Early-life sensory experience plays a critical role in aspects of neural development and human cognitive function. The proposed study investigates the molecular mechanisms by which the effects of experience coordinate with intrinsic genetic programs to drive neural circuit development.

PI_NAMEs: GREENBERG, MICHAEL ELDON (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;Adult;autism spectrum disorder;Automobile Driving;Binding;Birth;Brain;cell motility;Cell Proliferation;cell type;Cells;Central Nervous System;Cognition Disorders;cognitive function;Collaborations;combat;Cues;Development;developmental neurobiology;Disease;Distal;Enhancers;Environment;Event;experience;experimental study;Family;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene repression;gene-editing approach;Genes;Genetic;genetic approach;Genetic Enhancer Element;Genetic Transcription;Genome;Genomics;Heterogeneity;Human;Inbred Strains Mice;Individual;insight;Interneurons;Licensing;Life;mammalian genome;Mediating;Mediator;Molecular;Nervous System;nervous system development;neural;neural circuit;neurodevelopment;Neurodevelopmental Disorder;neuronal circuitry;Neurons;Pattern;Physiological;Physiology;Play;postnatal;postnatal development;postnatal period;Process;programs;Regulator Genes;Regulatory Element;Role;Sensory;Series;Shapes;Specific qualifier value;Stimulus;Technology;Testing;therapeutic development;Tissues;transcription factor;Transcription Factor AP-1;Transgenic Organisms;Up-Regulation;Variant;Work

PROJECT_TITLE: Mechanisms Underlying Neuronal Enhancer Specification During Postnatal CNS Development

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Childhood Injury;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Suicide;Suicide Prevention

PI_NAMEs: ADRIAN, MOLLY  (contact)

PROJECT_TERMS: Accident and Emergency department;Address;Adolescent and Young Adult;Adopted;Affect;aged;Behavior Therapy;Caring;Child health care;Client satisfaction;Clinical;clinical decision support;Clinical effectiveness;Clinical Research;Data;data harmonization;data repository;design;Detection;Discipline;Ecosystem;effective intervention;effectiveness research;Emergency department visit;Evaluation;evidence base;Evidence based practice;Family;Family Practice;Feeling suicidal;follow-up;Future;health care model;health care settings;Health Personnel;Health Services;Health Services Research;Healthcare;Healthcare Systems;human centered design;Hybrids;implementation barriers;implementation facilitation;implementation intervention;implementation trial;improved;Informatics;innovation;Intervention;Joints;Lead;Measurement;Measures;Medical;Methodology;Methods;Modeling;multi-component intervention;multidisciplinary;multiphase optimization strategy;National Institute of Mental Health;novel;operation;Outcome;Outpatients;Pathway interactions;Patients;Pediatrics;Phase;point of care;population based;pragmatic trial;Preparation;Prevention Research;preventive intervention;Process;Productivity;Provider;Psychology;Public Health;Recommendation;reducing suicide;Research;Research Personnel;Research Project Grants;Resources;response;Risk;Risk Assessment;Scientific Advances and Accomplishments;Scientific Inquiry;Self Efficacy;Services;suicidal behavior;suicidal patient;suicidal risk;Suicide;Suicide attempt;Suicide prevention;support tools;Surgeon;System;Technology;Therapeutic;therapy development;Time;trial design;Universities;usability;Washington;willingness

PROJECT_TITLE: Methods Core