NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Lupus;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE Serving as one of four disease teams of the Accelerating Medicines Partnership and Autoimmune Mediated Diseases (AMP-AIM) consortium, the Lupus Omics Cutaneous Kidney Investigative Team (LOCKIT) will enroll and follow an estimated 400 patients with Systemic Lupus Erythematosus (SLE) from nine centers across the country. The initial focus of inquiry will be on the kidney and skin given the high prevalence, severity, and remarkable heterogeneity with which SLE manifests in these organs, and the considerable but poorly understood influences of race, ethnicity, and socioeconomic status on disease phenotypes. With a high priority on identifying early kidney involvement and understanding what drives the range of skin rashes from acute to chronic, state-of the art and next generation analytics will be applied to interrogate tissues, blood, and urine from our informative populations, with the ultimate goal to identify novel targets for intervention.

PI_NAMEs: BUYON, JILL P (contact);PETRI, MICHELLE A;ROVIN, BRAD H;WERTH, VICTORIA P

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Acceleration;Acute;Adaptive Immune System;Address;Autoimmune;Autoimmune Diseases;B-Cell Activation;B-Lymphocytes;Beds;Biological;biological specimen archives;Biology;Biopsy;black women;Blood;California;Cause of Death;cell preparation;Cells;Chronic;Clinical;clinical infrastructure;clinical phenotype;clinically actionable;cohort;Collaborations;Collection;college;Communities;Consent;Country;Cutaneous;Data;data pipeline;Data Set;Databases;Dermatologist;design;digital imaging;Disease;disease classification;disease phenotype;Dissociation;Early identification;Elements;Endothelial Cells;Enrollment;Ethnic Origin;Exanthema;Fibroblasts;flexibility;Genetic;Goals;Heterogeneity;High Prevalence;Hospitals;image archival system;Immune;Immunologics;Informed Consent;Innate Immune System;Institutional Review Boards;Interferon Type I;Intervention;Investigation;Kidney;Kidney Diseases;Lead;Liquid substance;Lupus;lupus cutaneous;Lupus Nephritis;Mediating;medical schools;Medicine;men;Michigan;Molecular;Monitor;monocyte;multi-ethnic;multidisciplinary;next generation;novel;Ohio;Organ;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Pennsylvania;Periodicals;Peripheral;Phase;Phenotype;phenotypic data;Pilot Projects;Population;Prevalence;programs;Proteinuria;Proteomics;Protocols documentation;prototype;Publishing;Race;racial population;recruit;Recurrent disease;Registries;Regulation;Research Personnel;Research Priority;response;Rheumatology;Risk;Salivary Glands;Sampling;San Francisco;scale up;Severities;Site;Skin;skin biopsy;skin disorder;Socioeconomic Status;Specimen;Speed;success;Synovial Membrane;Systemic Lupus Erythematosus;Systems Biology;Technical Expertise;Technology;Texas;Therapeutic;Tissue Preservation;Tissue Procurements;Tissues;transcriptomics;translational applications;treatment response;Tubular formation;Underrepresented Minority;Universities;Urine;Woman;working group;Writing;young woman


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: Narrative Osteoarthritis (OA) is a widespread painful disease manifested by multiple pathological changes in the joint; but currently there are no strategies to efficiently deliver gene therapies in a cell- specific way. We propose a novel screen to identify nanoparticles that have specific affinities to various joint cells in OA. Therefore, this project is paradigm-shifting and relevant to public health, aligning with the NIH's mission to support innovative and high-impact research for treating OA.

PI_NAMEs: JOSHI, NITIN ;ZENG, LI  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Acceleration;Address;Affinity;Aging;Animals;Anterior Cruciate Ligament;Antibodies;arthropathies;Awareness;Bar Codes;Binding;biocompatible polymer;biodegradable polymer;Cartilage;Cell Communication;cell type;Cells;Chemicals;Chemistry;Chondrocytes;Chronic;clinically relevant;Collection;combinatorial;Degenerative polyarthritis;design;Disease;DNA;DNA Library;Effectiveness;Engineering;Environment;FDA approved;follow-up;Formulation;gene therapy;genetic signature;Genetic Transcription;Genomics;Glycolates;Goals;Heterogeneity;Histology;Human;In Vitro;in vivo;Individual;Injections;innovation;insight;Intra-Articular Injections;joint injury;Joints;Knee joint;Libraries;Macrophage;Mediating;Messenger RNA;Methods;Mission;Modification;Molecular Weight;mRNA delivery;Mus;Names;nano;nanoparticle;nanoparticle delivery;novel;Obesity;Pain;Pathologic;Population;preference;Property;Proteins;Public Health;rational design;Research;Resolution;Risk Factors;RNA delivery;screening;single-cell RNA sequencing;Single-Stranded DNA;Small Interfering RNA;small molecule;Sorting;success;Surface;Synovial Membrane;System;targeted delivery;Technology;Testing;Therapeutic;therapeutic RNA;Therapeutic Uses;Tissues;transcriptome;United States National Institutes of Health;uptake;Variant;Work

PROJECT_TITLE: Exploring nano-bio interactions for cell-specific targeting of osteoarthritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-L (03)]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The fitness and, ultimately, survival of an organism requires proper formation and positioning of both simple and complex epithelial tubular networks. Using the embryonic salivary gland of Drosophila as a model system, I seek to understand the processes underlying key stages of epithelial tube formation. I focus on two distinct morphogenetic processes: 1) the pathway that determines the order of primordial cell invagination to initiate salivary gland tube formation and 2) the ligand-receptor signaling molecules involved in subsequent salivary gland tube placement within the whole organism.

PI_NAMEs: SHOEMAKER, ASHLEIGH MARIE (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Affect;Animal Model;Apical;apical membrane;Autocrine Communication;Basement membrane;Binding Proteins;Biological Models;Blood;Body System;cell motility;Cell Physiology;Cell Shape;Cells;Complex;constriction;CRISPR/Cas technology;Data;Development;Disease;Dorsal;Drosophila genus;Drosophila melanogaster;Ectopic Expression;Embryo;Epithelium;Etiology;Fat Body;fitness;Fluorescence;fly;Fogs;G-Protein-Coupled Receptors;gastrointestinal system;gastrulation;Gene Expression;Gene Silencing;Generations;Genes;Genetic;genetic manipulation;Genetic Transcription;Human;insight;Integrins;Intercalated Cell;Internal Migrations;Kidney;Kinesin;Laboratories;Ligands;Link;loss of function;loss of function mutation;Lung;Mediating;Mediator;Mesoderm;Methods;migration;model organism;Modeling;Molecular;Morphogenesis;Movement;mutant;Mutate;Organ;Organism;Paracrine Communication;Pathway interactions;Play;Positioning Attribute;Process;receptor;receptor function;Receptor Gene;Receptor Signaling;Research;response;RNA Interference;Role;Salivary Glands;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Smooth Muscle Myocytes;Specificity;Stains;Stomach;superresolution microscopy;Supine Position;System;Testing;Tissues;tool;trafficking;transcription factor;transcriptomics;Tube;Tubular formation;Vertebrates;Vesicle;vesicle transport;Visceral;Whole Organism;Work

PROJECT_TITLE: How Signaling Molecules Affect the Invagination and Posterior Migration of the Drosophila Salivary Gland

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 JC (18)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Despite unprecedented clinical success in the treatment of advanced cancers, immune checkpoint inhibitors are associated with immune-related adverse events. Understanding the mechanisms of immune-related adverse events is critical to identify valid biomarkers to predict and assess these events and to establish the optimal treatment strategy targeting autoimmunity while preserving antitumor immunity, both of which are triggered by immune checkpoint inhibitors. This work seeks to determine the cellular and molecular mechanisms underlying arthritis associated with immune checkpoint inhibitor therapy by utilizing patient samples.

PI_NAMEs: KIM, SANG TAEK (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Antigens;Arthritis;autoimmune arthritis;Autoimmune Diseases;Autoimmunity;Biological Markers;Biology;biomarker driven;Biometry;Blood;Blood specimen;bone erosion;cancer genomics;cancer immunotherapy;cancer therapy;carcinogenesis;career;career development;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;checkpoint therapy;Clinical;cohort;Collection;Combined Modality Therapy;Complex;CTLA4 gene;Data;Development;Disease;Disease-Modifying Second-Line Drugs;Doctor of Philosophy;Dose;Epidemiology;Event;experience;Fellowship;functional genomics;Genomics;Goals;Hospitalization;Immune;Immune checkpoint inhibitor;Immune system;immune-related adverse events;Immunity;Immunobiology;Immunogenomics;Immunologics;Immunology;in vivo;Inflammation;Inflammatory Arthritis;inhibitor;inhibitor therapy;innovation;insight;Malignant Neoplasms;Mentors;Mentorship;Methods;Molecular;mouse model;Oncology;optimal treatments;Pathogenesis;Patients;peripheral blood;Physicians;Play;PPBP gene;Prednisone;preservation;Principal Investigator;programmed cell death protein 1;Psoriatic Arthritis;Regulatory T-Lymphocyte;Research;Research Personnel;Research Training;Resistance;Rheumatoid Arthritis;Rheumatology;Role;Sampling;Scientist;Specificity;Steroid Resistance;Steroids;success;Synovial Fluid;T-Lymphocyte;Technology;Th1 Cells;Therapeutic;tool;Training;Training Programs;treatment strategy;tumor;Tumor Immunity;tumor immunology;Universities;Work

PROJECT_TITLE: Characterization of Altered Immunity in Patients with Inflammatory Arthritis Induced by Immune Checkpoint Inhibitor Therapy

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOLOGY

PHR: PROJECT NARRATIVE  In nature, different sexes of a species must determine their sexual identity within the germline in order to create proper sex-specific gametes. Animals such as humans and flies rely on proper transcriptional signals as well as post-transcriptional gene regulation through RNA binding proteins to ensure proper sexual identity and germline development. Determining these mechanisms is critical for understanding the multiple levels by which sex-specific gene expression is regulated in the germline and can further treatment of human syndromes leading to infertility.

PI_NAMEs: CURNUTTE, HARRISON  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: 3' Untranslated Regions;Adult;Affect;Animals;Binding;Binding Sites;Cues;Data;Defect;derepression;Development;DNA;Drosophila genus;Elements;Embryo;Embryonic Development;Ensure;Exhibits;Female;fly;gene discovery;Gene Expression;Genetic Transcription;Germ Cells;Germ Lines;germline stem cells;gonad development;Gonadal structure;Human;Infertility;infertility treatment;insight;interest;Introns;knock-down;male;Messenger RNA;Modeling;Molecular;Nature;neuronal cell body;Post-Transcriptional Regulation;posttranscriptional;promoter;protein expression;Proteins;Regulation;Reporter;Repression;RNA;RNA Stability;RNA-Binding Proteins;Role;sex;sex determination;sexual identity;Signal Pathway;Signal Transduction;Somatic Cell;Spermatocytes;Spermatogenesis;Syndrome;Transcriptional Regulation;Undifferentiated

PROJECT_TITLE: Investigating how germline sexual identity controls sex-specific gene expression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE A hexanucleotide repeat expansion mutation in the C9ORF72 gene is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), two devastating neurodegenerative diseases which have few treatments and no known cure. The repeat is bidirectionally transcribed, and RNA and proteins encoded by the antisense strand have been shown to contribute to neurodegeneration in ALS/FTD but are understudied. This project aims to study transcription of the antisense repeat RNA, as well design and evaluate putative therapeutic strategies specifically targeting antisense transcription and translation.

PI_NAMEs: ANTONOPOULOS, MIRA N (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Amyotrophic Lateral Sclerosis;Anti-sense RNA;Antisense Oligonucleotides;Base Sequence;behavioral phenotyping;Binding;Biological Assay;Biological Models;Brain;C9ORF72;Cell Death;Cell model;Cells;Central Nervous System;Cessation of life;Clinical Trials;Cognition;Complementary DNA;CRISPR interference;CRISPR/Cas technology;Data;design;Dipeptides;Disease;Disease Progression;DNA;efficacy evaluation;Embryo;Enzymes;familial amyotrophic lateral sclerosis;Friedreich Ataxia;frontotemporal lobar dementia amyotrophic lateral sclerosis;gain of function;Genes;Genetic;Genetic Transcription;Goals;Human;Huntington Disease;Hybrids;improved;In Vitro;in vivo;induced pluripotent stem cell;interest;Introns;Kidney;Knowledge;Life Expectancy;Locomotion;loss of function;Motor;Motor Cortex;Motor Neurons;mouse model;Mus;Mutagenesis;Mutate;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;new therapeutic target;Pathogenesis;Pathology;patient derived induced pluripotent stem cells;Patient-Focused Outcomes;Patients;postmitotic;prevent;Proteins;reduce symptoms;RNA;Site;Spinocerebellar Ataxias;sporadic amyotrophic lateral sclerosis;Symptoms;targeted treatment;Therapeutic;therapeutic target;Toxic effect;Transcript;Transcription Initiation;Transcription Initiation Site;Translating;Translations;Work

PROJECT_TITLE: Targeting transcription and translation of the antisense CCCCGG repeat expansion in C9ORF72 ALS/FTD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Nanotechnology

ORG_CITY: Newark

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative Block copolymers, when poured into a film, make unique nanostructures. We are exploring if these nanostructures can lead to distinctive tactile sensations in a tactile aid, which would expand the toolkit for designers of tactile aids and benefit users who are blind or severely visually impaired.

PI_NAMEs: DHONG, CHARLES B. (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TITLE: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp)


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative The processing and categorization of behaviorally relevant complex auditory stimuli is a skill often critical to engaging with one’s environment, but the neural circuitry underlying this skill remains poorly understood. Many aging adults have difficulty parsing speech in noisy settings, cochlear implant users report poor quality of harmonically complex sounds such as music, and conditions like central auditory processing disorders profoundly affect the quality of life for many individuals. Identifying a causal relationship between the activity of auditory cortical ensembles and the perception and categorization of complex harmonic stimuli will lay the groundwork for a more complete understanding of auditory processing disorders, and could serve to motivate the design of cochlear implants to improve quality of life for users.

PI_NAMEs: DAHER, JADE  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acoustic Stimulation;Address;Adult;Affect;Aging;Animal Behavior;Animals;Attention;Auditory;Auditory area;auditory categorization;Auditory Perceptual Disorders;auditory processing;auditory stimulus;Auditory system;Behavior;Behavioral;behavioral outcome;behavioral response;Categories;Cells;Central Auditory Processing Disorder;Cochlear Implants;Code;Communication;Complex;design;Detection;discrimination task;Environment;Etiology;experience;Frequencies;Head;holographic stimulation;Holography;Human;improved;Individual;Link;Mus;Music;Nature;neural;neural circuit;Neurons;optogenetics;Outcome;Pathway interactions;Perception;Periodicals;Periodicity;Play;Population;Population Dynamics;preference;Process;Proxy;Quality of life;Reporting;Research;response;Role;skills;sound;Speech;Stimulus;Structure;Task Performances;Techniques;Training;vocalization;Work

PROJECT_TITLE: Population coding of complex auditory stimuli in auditory cortex

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (15)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The cingulum bundle serves a critical role in mediating connectivity among mood-related regions and is implicated in several psychiatric disorders. The proposed research will investigate how variable local paracingulate sulcal pattern alters structural and functional effective cingulum bundle connectivity. This work will highlight the contribution of interindividual anatomical variability to brain connectivity in addition to informing patient-specific, neurosurgical approaches targeting the cingulum bundle for treatment-refractory psychiatric disorder intervention.

PI_NAMEs: DANSTROM, ISABEL ANASTASIA (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Affect;Affective;Amygdaloid structure;Anatomy;Anterior;Area;Brain;Brain region;Cerebral hemisphere;cingulate cortex;Classification;Clinical;Cognitive;Communication;Comprehension;Consensus;Deep Brain Stimulation;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Dorsal;Electrodes;Electroencephalography;Electrophysiology (science);Emotional;Evoked Potentials;Exhibits;Feedback;Fiber;Functional disorder;Goals;gray matter;Human;Image;improved;Individual;insight;inter-individual variation;Intervention;Length;Magnetic Resonance Imaging;Major Depressive Disorder;Medial;Mediating;Mental Depression;Mental disorders;Mental Health;Methods;Monitor;Mood Disorders;Moods;Morphology;neurosurgery;novel;Operative Surgical Procedures;optimal treatments;patient response;Patients;Pattern;Pharmaceutical Preparations;Physiologic pulse;Population;Positioning Attribute;Prediction of Response to Therapy;Prefrontal Cortex;Quality of life;Refractory;Regulation;Research;Resolution;response;Rest;Role;Sampling;Source;Spatial Distribution;spatial relationship;success;System;Techniques;Therapeutic;therapy resistant;tractography;treatment optimization;treatment response;treatment-resistant depression;Variant;white matter;Width;Work

PROJECT_TITLE: THE ROLE OF PARACINGULATE SULCAL MORPHOLOGY IN AFFECTIVE NETWORK CONNECTIVITY

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-E (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Prefrontal parvalbumin (PV) interneuron activity during early development is required for shaping prefrontal cortex connectivity, function, and cognitive flexibility, which go awry in psychiatric disorders like depression, schizophrenia and attention-deficit hyperactivity disorder; however, the factors responsible for altering PV interneuron activity are largely unknown. Here, we aim to elucidate the neurodevelopmental impact of serotonin on PV interneuron excitability and cognitive behavior by employing a combination of cellular, circuit and behavioral approaches. This proposed work would have tremendous public health relevance, as the research outlined will 1) provide insight into the development of neural circuitry supporting cognitive function; 2) promote newfound understanding of early risk factors of psychiatric disease 3) enable identification of timepoints for effective prevention and treatment of cognitive impairments.

PI_NAMEs: ANQUEIRA, AMANDA  (contact)

PROJECT_TERMS: Acute;Address;Adult;Affect;Attention;Attention deficit hyperactivity disorder;Behavior;Behavioral;Biological Assay;Birth;brain circuitry;Cells;Chemosensitization;Cognition;Cognitive;cognitive function;Complex;Data;Development;Dimensions;Disease;Early identification;Electrophysiology (science);emotional behavior;Environmental Risk Factor;Etiology;experience;Experimental Designs;experimental study;Fiber;flexibility;Functional disorder;Genetic;Goals;Impaired cognition;Impairment;implantation;improved;In Vitro;in vivo;in vivo Model;insight;interest;Interneurons;Life;Mental Depression;Mental disorders;Mus;nerve supply;neural;neural circuit;neurodevelopment;Neuromodulator;Onset of illness;Opsin;optical fiber;optogenetics;Parvalbumins;Pattern;Pharmacologic Substance;Phosphorus 32;Photometry;Positioning Attribute;postnatal;postnatal development;Prefrontal Cortex;Prevention;public health relevance;receptor expression;Research;Research Personnel;Risk;Risk Factors;Rodent;Schizophrenia;Selective Serotonin Reuptake Inhibitor;Serotonin;serotonin receptor;Shapes;Signal Transduction;Slice;Stress;Testing;Training;Viral;Virus;Work

PROJECT_TITLE: Impact of developmental serotonin on prefrontal cortex parvalbumin interneuron excitability and cognitive behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Precision Medicine;Prevention;Rheumatoid Arthritis

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Individuals who have developed rheumatoid arthritis (RA) demonstrate several unique types of inflammatory and autoimmune cell patterns in the inflamed synovium. Molecular dissection of the synovial tissue in patients with RA has identified a number of new features with pathogenic, personalized therapeutic and prognostic importance. Using a pipeline of synovial samples obtained from patients with RA, this group will advance the field by increasing our understanding of the three-dimensional architecture and mechanisms by which cell populations interact both with each other and the systemic immune system, as well as interlink these phenotypes to patient characteristics and response to specific therapy.

PI_NAMEs: ANOLIK, JENNIFER HOWITT (contact);DONLIN, LAURA T.;MORELAND, LARRY W

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: 3-Dimensional;Address;adverse outcome;Affect;Algorithms;Architecture;Area;Arthritis;Artificial Intelligence;Autoantibodies;Autoimmune;B-Lymphocytes;Binding;biobank;Biological;Biological Markers;Biological Response Modifier Therapy;Biopsy;bone cell;Cell Communication;Cells;Characteristics;Classification;Clinical;clinical phenotype;Clinical Research;Clinical Trials;cohort;Complement;Data;design;Diagnosis;disability;Disease;Disease Outcome;Disease remission;Disease-Modifying Second-Line Drugs;disorder prevention;Dissection;Dissociation;Drug Targeting;Early treatment;effector T cell;Enrollment;Ensure;Environmental Exposure;epigenetic regulation;Evolution;Failure;Fibroblasts;Flare;follow-up;Funding;Generations;Goals;Heterogeneity;high dimensionality;Histology;Image;Immune;Immune system;improved;In Situ;Individual;individualized medicine;Inflammation;Inflammatory;innovation;joint inflammation;joint injury;Knowledge;Longitudinal Studies;Measurement;Mediator;Methotrexate;Molecular;Molecular Analysis;monocyte;multimodal data;multimodality;novel;Onset of illness;Oranges;Outcome;Pain;Pathogenesis;Pathogenicity;Pathologic Processes;Pathway interactions;Patient Care;Patient Recruitments;patient retention;Patients;Pattern;personalized therapeutic;Phenotype;phenotypic data;Population;Positioning Attribute;pre-clinical;Precision therapeutics;Preparation;prevent;Prevention strategy;Process;prognostic;programs;Protocols documentation;Psoriatic Arthritis;reconstruction;Research Personnel;response;Rheumatoid Arthritis;Risk;Role;Sampling;Science;Selection for Treatments;Seminal;Site;small molecule;Specimen;standard of care;Synovial Cell;Synovial Fluid;Synovial Membrane;Synovitis;Systemic Lupus Erythematosus;Technology;tissue reconstruction;Tissue Sample;Tissues;transcriptomics;translational applications;Treatment Failure;Treatment outcome;treatment response;treatment strategy;United States National Institutes of Health;Variant

PROJECT_TITLE: AIM-for-RA


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Anxiety disorders are the most prevalent psychiatric conditions in the United States today, yet there is an absence of safe, non-invasive, and precise neuromodulatory techniques to treat these conditions. This application proposes to translate to human transcranial applications a new neuroimaging modality called magnetic- resonance acoustic radiation force impulse (MR-ARFI) imaging to visualize with accuracy and precision what brain region is being treated with focused ultrasound. The technique introduced here might thus provide a new approach to help reduce the burden of mental illness and holds neuromodulation and mental health care, which has the potential individuals and their families.  promise in revolutionizing the field of to restore the quality of life in affected

PI_NAMEs: SPIVAK, NORMAN MITCHEL (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: 3-Dimensional;Acoustics;Address;Adjuvant;Affect;American;Amygdaloid structure;Animal Model;Anxiety;Anxiety Disorders;anxiety reduction;Area;arterial spin labeling;Behavioral;Brain;Brain Mapping;Brain region;burden of illness;Cephalic;Clinical;Clinical Trials;Computer Models;Computer software;Data;Deep Brain Stimulation;design;Diagnosis;Diagnostic;Evaluation;Face;Family;Fellowship;Focused Ultrasound;Focused Ultrasound Therapy;generalized anxiety;Generalized Anxiety Disorder;Goals;Human;human imaging;human subject;Hyperactivity;Image;improved;in vivo;Individual;Location;Magnetic Resonance;Magnetic Resonance Imaging;Measures;Mental disorders;Mental Health;Mental Health Services;meter;Methods;Modality;Modeling;Motion;neuroimaging;neuropathology;neuropsychiatric disorder;neuropsychiatry;neuroregulation;novel;novel strategies;Output;patient population;Patients;Perfusion;Physiologic pulse;Population;Positioning Attribute;predictive modeling;pressure;Property;Protocols documentation;Psychopharmacology;Psychotherapy;Quality of life;Radiation;Refractory;Research;Research Project Grants;Scientist;skills;sound;Structure;Sum;Techniques;Technology;Testing;Therapeutic;Time;Tissues;Training;Transcranial magnetic stimulation;Transducers;Translating;treatment optimization;treatment strategy;Ultrasonics;ultrasound;United States;Validation;Visualization

PROJECT_TITLE: Seeing Sound: Visualizing the Target of Transcranial Focused Ultrasound

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Breast cancer mortality rates in Black women, particularly amongst Haitian immigrants, remain alarmingly high, exhibiting disparate outcomes. The proposed project considers how immigration as an exposure affects the epigenetic distinctions between Haitian immigrants, Haitians in Haiti, and US-born Black women with breast cancer. Additionally, we aim to explore the association between perceived stress and discrimination and aggressive tumor biology, as mediated by the presence of language barriers amongst Haitian immigrants.

PI_NAMEs: RAVIX, JOVANKA L (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: advanced disease;Affect;African;African Caribbean;Age;age difference;Alcohols;Articulation;Automobile Driving;Biological;Biology;Birth;black patient;Black Populations;Black race;black women;Cancer Death Rates;cancer genome;cancer health disparity;Carcinoma;Caribbean region;Characteristics;cohort;Country;Data;Death Rate;Diagnosis;Discrimination;Disease Pathway;Disparity;DNA;DNA Methylation;Economics;Education;Epigenetic Process;epigenetic variation;Estrogen receptor negative;Estrogen receptor positive;Estrogen Receptor Status;Ethnic Population;Exhibits;experience;Face;Florida;Germ Lines;Haiti;Haitian;Health;health care availability;health disparity;Immigrant;Immigration;Incidence;Income;Individual;Language;Latin America;lens;Malignant Breast Neoplasm;Mammary Neoplasms;Mediating;Mediation;Mediator;Methylation;migration;Minority Groups;Minority Status;Modality;mortality;National Institute on Minority Health and Health Disparities;Nature;Outcome;outcome disparities;Output;Patients;perceived discrimination;perceived stress;Play;preference;psychosocial;racial population;receptor;Registries;Regression Analysis;Research;Role;Saliva;Shapes;skills;Smoking;social culture;stem;Stress;Surveys;survival disparity;triple-negative invasive breast carcinoma;tumor;Tumor Biology;Tumor stage;Universities;White Women;Woman;women's diagnosis

PROJECT_TITLE: Investigating Breast Cancer Outcomes in Haitian Immigrants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Rare Diseases;Rehabilitation;Stroke

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Post-stroke alexia, an acquired reading disorder affecting approximately 1.3 million Americans, causes a great deal of suffering and recovery is limited. The proposed research seeks to elucidate the neural mechanisms underlying post-stroke alexia by investigating functional changes in the visual word form system following damage to the language network. By investigating the relationship between atypical brain activity patterns, lesion characteristics, and behavioral deficits, this study will enhance our understanding of neural plasticity in alexia recovery and offer insights to inform targeted interventions for stroke survivors.

PI_NAMEs: DYSLIN, SARA MARIE (contact)

PROJECT_TERMS: Affect;Alexia;American;Anatomy;angular gyrus;Aphasia;aphasia recovery;Area;Behavioral;Behavioral Research;Brain;Brain region;career development;Case Study;Characteristics;Chronic;Clinical;Cognitive;cognitive function;cognitive neuroscience;comorbidity;Complex;Comprehension;connectome;Data;design;Feedback;Feeds;frontal lobe;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Individual;Inferior frontal gyrus;Influentials;Injury;insight;Knowledge;Language;language impairment;language processing;Learning;Learning Skill;Left;Lesion;lexical;Life;Localized Lesion;Location;Maps;Measures;Mentors;Mentorship;Methodology;Modeling;Modernization;Neurobiology;neuroimaging;neuromechanism;Neuronal Plasticity;Neuropsychology;novel;object recognition;Occipital lobe;Oral;Orthography;Outcome;Participant;Pattern;Performance;Persons;Population;post stroke;Process;Property;Prospective Studies;Reading;reading ability;reading difficulties;Reading Disorder;Recovery;recruit;Research;Research Personnel;Role;Running;skills;Societies;speech processing;Statistical Data Interpretation;Stroke;stroke intervention;stroke survivor;Structure of middle temporal gyrus;Structure of superior temporal sulcus;Structure of supramarginal gyrus;Symptoms;System;Techniques;Testing;Training;Visual;visual information;visual processing;visual stimulus;white matter;Word Processing;Writing

PROJECT_TITLE: Investigating functional changes to the visual word form system in post-stroke alexia

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (36)]


NIH_SPENDING_CATS: Behavioral and Social Science;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homicide and Legal Interventions;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

PHR: Project Narrative This project will build a granular, longitudinal database of local funding expenditures for the carceral system and community support services, thereby creating the ability to rigorously assess local budgets as structural determinants of health. The project will then use this novel database to assess the effect of local funding allocations on inequities in firearm violence, which disproportionately impacts segregated Black and Latiné communities. These findings can help inform local policymakers about modifying budgetary allocations as a strategy to address firearm violence.

PI_NAMEs: BURKE, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Area;Black Populations;Black race;Budgets;built environment;career;Categories;Cities;clinical care;Communication;Communities;community violence;County;Criminal Justice;dashboard;Data;Databases;deprivation;Disparity;Education;ethnic disparity;Ethnic Population;Evaluation;evidence base;Expenditure;Family;family support;Feedback;Financial Support;Firearms;Foundations;Funding;Funding Agency;Funding Category;Geographic Locations;Goals;gun violence;Health;health disparity;health equity promotion;Healthcare;Homicide;Housing;Imprisonment;indexing;Individual;inequitable distribution;Inequity;Interpersonal Violence;Intervention;Investments;Knowledge;Latinx;Lead;lens;Letters;Local Government;longitudinal database;marginalization;meetings;Mentors;Mentorship;Methods;Minority;Modeling;Municipalities;National Institute on Minority Health and Health Disparities;Neighborhoods;Not Hispanic or Latino;novel;open source;Operative Surgical Procedures;Outcome;Pattern;Persons;Police;Policy Analysis;Policy Maker;Positioning Attribute;prevent;Prevention;Process;public database;Publishing;racial disparity;racial population;Racial Segregation;Research;Resources;Safety;school district;Science;segregation;Services;skills;social media;Source;stem;Strategic Planning;structural determinants;structural health determinants;Structural Racism;Subgroup;success;System;Training;trauma surgery;trend;United States;Violence;Youth

PROJECT_TITLE: Local government expenditures as structural determinants of racial and ethnic disparities in firearm homicides


NIH_SPENDING_CATS: Neurosciences

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative Sensations we perceive arise from both the external environment as well as our own actions, and we learn to expect that certain movements will elicit predictable acoustic consequences. However, the same motor action can often lead to different sensory outcomes, and it is known that the suppression of self-generated sounds in the auditory cortex is highly sensory specific, but the degree to which the motor system reflects both the execution of an action, and its anticipated sensory outcome, is unclear. This proposal will provide valuable insights into the brain’s mechanisms for predicting and updating its encoding of self-generated sounds in real time and uncover fundamental principles underlying the dynamic information flow between sensory and motor regions of the brain.

PI_NAMEs: KLINE, AMBER M (contact)

PROJECT_TERMS: Acoustics;area striata;Auditory;Auditory area;Auditory Perception;Auditory system;Back;Behavior;Brain;Brain region;Calcium;cellular imaging;Chronic;Color;Communication;Data Analyses;Electrophysiology (science);Environment;Esthesia;expectation;experience;experimental study;genetic approach;Image;insight;Label;Learning;life span;Measures;Mediating;Monitor;Motor;Motor Cortex;motor learning;Movement;Mus;Music;neural;neuronal patterning;Neurons;novel;Outcome;Population;Population Dynamics;Positioning Attribute;predicting response;Reproducibility;response;Rewards;Role;Sensory;sensory cortex;Signal Transduction;sound;Source;Stimulus;System;Testing;Time;Tracer;Training;two-photon;Update;Viral;Visual Cortex;visual stimulus;Water

PROJECT_TITLE: Long-range exchange of expectation, experience and error during auditory-motor learning


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Genetics;Hematology;Human Genome;Infectious Diseases;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Sepsis

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Despite the use of state-of-the-art supportive care and a variety of novel anti-inflammatory agents in critically ill/injured patients, multiple organ failure continues to be a major cause of morbidity/mortality in the surgical intensive care unit. This study is designed to determine if a family of novel checkpoint proteins, expressed on immune and non-immune cells, can be used to block the development of organ injury in the critically ill patient.

PI_NAMEs: AYALA, ALFRED  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Accounting;Acute Lung Injury;Adoptive Transfer;Age;Animals;Anti-Inflammatory Agents;Apoptosis;Area;ATAC-seq;Automobile Driving;bisulfite;Cause of Death;cecal ligation puncture;Cell surface;Cells;Cessation of life;Clinical Research;comparative;Consensus;Cre-LoxP;Critical Illness;Defect;design;Developed Countries;Development;Endothelium;Epigenetic Process;epigenomics;Epithelial Cells;Etiology;Event;examination questions;Family;Frustration;Genetic;Hemorrhagic Shock;Hospitals;Immune;immune function;Immune system;Immune System Diseases;Immunoglobulin Domain;Immunologic Memory;Incidence;inhibitor;injured;Injury;Intensive Care Units;Intestines;kidney dysfunction;Leukocytes;Ligands;Liver;Lung;Lymphoid Cell;member;microbiota;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Multiple Organ Failure;Myelogenous;neonatal sepsis;neonate;novel;organ growth;organ injury;Outcome;patient population;Patients;Population;Predisposition;Prognostic Marker;programs;protein expression;Protein Family;Proteins;pyrosequencing;receptor;Reporting;response;Role;SARS-CoV-2 infection;Sepsis;septic;Shock;single-cell RNA sequencing;Supportive care;Suppressor-Effector T-Lymphocytes;Surgical Intensive Care;Survivors;T-Cell Activation;T-Lymphocyte;therapeutic target;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Mechanism of Immune Dysfunction and Morbid Outcomes in Response to Shock/Sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PI_NAMEs: ANDERSEN, KRISTIAN GRAUGAARD (contact)

PROGRAM_OFFICER_NAME: KWON, KEEHWAN

PROJECT_TERMS: Africa;Bioinformatics;Budgets;Clinical;cohort;Collaborations;Communicable Diseases;Communication;Communities;Coordination and Collaboration;cost effective;COVID-19 pandemic;data management;data sharing;data sharing networks;Educational workshop;Ensure;Funding;General Population;Goals;Infectious Diseases Research;Leadership;Manuscripts;meetings;member;Modeling;Monitor;National Institute of Allergy and Infectious Disease;open source;operation;organizational structure;outreach;Postdoctoral Fellow;Preparation;programs;Progress Reports;Research;Research Project Grants;Research Support;Resources;Schedule;Scientist;Site;Structure;Students;symposium;Systems Biology;Technology;timeline;Travel;Viral

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases;Lung;Orphan Drug;Patient Safety;Primary Health Care;Rare Diseases;Tuberculosis

PHR: This administrative supplement supports the BringBPaL2Me Trial to fully meet trial aims. Newer treatment regimens for antibiotic resistant TB are shorter, better tolerated and have greatly improved treatment outcomes, yet access to these regimens is limited to physician-led, hospital-based programs. The BringBPaL2Me Trial is testing whether it is safe and effective to offer such treatment in a primary care clinic using a nurse-led treatment model, as such, this trial has great potential to improve access to care and significantly reduce patient and health system costs.

PI_NAMEs: EVANS, DENISE ;FARLEY, JASON EDWARD (contact);NDJEKA, NORBERT ODIMBOLEKO

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Adjuvant Analgesic;Administrative Supplement;Ambulatory Care;Antibiotic Resistance;arm;Blinded;Caring;Clinical;co-infection;cost;cost-effectiveness evaluation;Decentralization;Diagnosis;District Hospitals;Dose;Enrollment;Event;experience;Guidelines;Health Services Accessibility;Health system;HIV;HIV/TB;Hospitals;Household;Improve Access;improved;Income;Levaquin;Linezolid;Medication Management;Modeling;Mycobacterium tuberculosis;Nurses;outpatient programs;Outpatients;Participant;patient oriented;Patients;Pharmaceutical Preparations;Physicians;Predisposition;Primary Care;primary care clinic;Principal Investigator;programs;provider adherence;Province;Randomized;Regimen;Resistance;Resolution;Review Committee;Rifampicin resistance;Safety;Serious Adverse Event;Site;South Africa;standard of care;success;Symptoms;Testing;Time;treatment center;Treatment outcome;Treatment Protocols;trial comparing;Tuberculosis;tuberculosis treatment;Viral

PROJECT_TITLE: The Bring BPaL2Me Trial - Comparing Nurse-Led RR-TB Treatment in Primary Care to Physician-Led, Hospital-Based RR-TB Treatment: A Cluster Randomized, Non-Inferiority Trial

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Nutrition;Obesity;Pediatric;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative Colorectal cancer is a significant cause of death worldwide and is driven by modifiable risk factors like obesity and metabolic disorders. Our proposal aims to leverage public datasets and colonic organoids to model early- life metabolic exposures to profile genomic mutations in functional loci that may increase CRC susceptibility.

PI_NAMEs: LI, YUN ROSE (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Age;Biological Markers;Biological Models;cancer diagnosis;Cancer Etiology;cancer risk;carcinogenesis;Cause of Death;Cessation of life;Childhood;Chromatin;Chronic;chronic inflammatory disease;Colon;Colorectal;Colorectal Cancer;colorectal cancer risk;Computer Analysis;computerized tools;Data;Data Set;Developed Countries;Development;Diagnosis;DNA Damage;early life exposure;early onset colorectal cancer;Exposure to;Funding;genome sequencing;genomic profiles;Genotype-Tissue Expression Project;high risk;Human BioMolecular Atlas Program;Hyperglycemia;In Vitro;Incidence;Individual;induced pluripotent stem cell;Inflammation;Life;Life Style;lifestyle factors;Link;Malignant Neoplasms;Maps;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Mission;Modeling;modifiable risk;Molecular;multiple omics;Mutagenesis;Mutagens;Mutation;Obesity;Organoids;Overweight;Oxidative Stress;Oxidative Stress Induction;parent grant;Pathway interactions;Predisposition;Reactive Oxygen Species;Recommendation;Risk Factors;Role;routine screening;Site;Somatic Mutation;Staging;stem;stem cells;Techniques;Unhealthy Diet;United States National Institutes of Health;whole genome;young adult

PROJECT_TITLE: Diversity Supplement to "Biomarkers, mechanisms and modulation of oxidative stress associated risk factors in carcinogenesis"

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases

ORG_DEPT: BIOPHYSICS

PHR: Project Narrative The effects of aging can be offset by supplying the tissue with rejuvenated niche cells. The testis of the fruit fly Drosophila is an ideal model to study niche cells and how they are affected by aging. Our study is designed to identify niche cell genes that change during aging and may open up new therapies for treating human age- related male infertility.

PI_NAMEs: BACH, ERIKA A (contact)

PROGRAM_OFFICER_NAME: WANG, FEI

PROJECT_TERMS: Activin Receptor;Activins;Adult;Affect;Age;age effect;age related;age related changes;age related decline;aged;Aging;antagonist;Antibodies;Binding;Bioinformatics;Candidate Disease Gene;Cell Aging;Cell Count;Cell Cycle;Cell Maintenance;Cell Nucleus;Cell Physiology;Cell Proliferation;Cells;Chronic;Cloning;Complex;Cues;Cyst;design;differential expression;Drosophila genus;Enhancers;Epitopes;expression vector;Extracellular Matrix;fertility preservation;fly;Follistatin;Fostering;Gene Expression;Genes;Genetic;germline stem cells;Goals;heparin proteoglycan;Homologous Gene;Human;Immunofluorescence Immunologic;In Situ Hybridization;in vivo;Infertility;insight;Intrinsic factor;Knowledge;knowledge base;Ligands;male;Male Infertility;Messenger RNA;Modeling;Monitor;novel therapeutics;overexpression;Pathway interactions;perlecan;Phosphorylation;Population;Process;Proliferating;Proteins;Publishing;Reagent;receptor;Receptor Signaling;Rejuvenation;Reporter;Research;Role;self-renewal;Signal Transduction;Somatic Cell;Spermatogenesis;stem cell function;stem cell niche;stem cell population;stem cells;stemness;Surface;System;Techniques;Testing;Testis;Tissues;tool;Transcript;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;transdifferentiation;Transforming Growth Factor beta;Work

PROJECT_TITLE: Characterization of age-related changes in the testis stem cell niche

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Four in ten young children in the United States are born into low-income families, and they face risks in kindergarten-readiness skills including language and socioemotional development. In this two-brain study of caregivers and children ages 2-6, I will investigate the real-time relationship between caregiver sensitivity (attunement, warmth, and responsiveness to a young child) and preschoolers’ prefrontal cortex synchrony, and further test the relationship between caregiver-child prefrontal cortex synchrony and child language and emotion regulation development. By uncovering moment-to-moment relational mechanisms of children’s learning and development, we can shape policies (e.g., paid parental leave, high-quality Pre-K, Head Start) that buffer young children against SES risks far outside of their families’ control.

PI_NAMEs: ROCHE, ELLEN  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 4 year old;Address;Age;Area;Automobile Driving;Behavior;Behavioral Mechanisms;behavioral study;Brain;brain research;Buffers;career;Caregivers;Child;Child Behavior;Child Development;Child Language;Code;Cognitive;Color;Complex;Cortical Synchronization;Data;Dedications;Development;Disparity;emotion regulation;Emotional;Ethnic Origin;experience;Face;Family;Fathers;Fellowship;functional near infrared spectroscopy;girls;Head Start Program;Individual;kindergarten;Knowledge;Language;Lead;Learning;Link;low socioeconomic status;lower income families;marginalized community;Mediating;Mental Health;Methods;Modeling;Mothers;National Research Service Awards;neural;neuromechanism;novel;Nursery Schools;Outcome;Parental Leave;Parents;Policies;Prefrontal Cortex;primary caregiver;Process;Race;Readiness;Reporting;Research;Risk;Sampling;scaffold;Shapes;skills;social;socioeconomic disparity;Socioeconomic Status;socioeconomics;Standardization;Testing;Time;Time Factors;Training;Training Activity;Training Support;United States

PROJECT_TITLE: Development in the Moment: Does Caregiver Sensitivity Drive Prefrontal Cortex Synchrony?


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Second generation antipsychotics (SGAs) are widely used clinical tools, but they often take weeks to become effective, and the mechanism of this time course is not understood. Here, using in vivo optical methods, transgenic mice, and receptor radiolabeling, I will determine a mechanism of tolerance development to select SGAs at gross anatomy, cell-type, and protein levels. This will provide critical insight how these drugs alter the dopaminergic circuitry and explain the clinical time course of SGAs and, attribution of SGA tolerance to specific dopaminergic projections could inform the development of better antipsychotic treatments.

PI_NAMEs: LEWIS, ELINOR  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Agonist;Anatomy;antagonist;Antipsychotic Agents;arrestin3;Arrestins;behavior measurement;Behavioral;behavioral response;behavioral tolerance;Binding;Brain;Brain region;Calcium;Cell membrane;Cell Nucleus;cell type;Cells;Chronic;Clinical;Clozapine;conditional knockout;Corpus striatum structure;Data;Degradation Pathway;Development;Dopamine;Dopamine D2 Receptor;dopamine D3 receptor;Dorsal;druggable target;Effectiveness;Endocytosis;experimental study;Fiber;Generations;Goals;Impairment;In Vitro;in vivo;Injections;insight;Knockout Mice;Lead;Literature;Locomotion;Measures;Membrane;Molecular;Mus;neural correlate;Neurons;novel;Optical Methods;Panthera leo;Pathway interactions;Patients;Pharmaceutical Preparations;Photometry;Positron-Emission Tomography;pre-clinical;Prefrontal Cortex;Proteins;quetiapine;Radiolabeled;radioligand;receptor;recruit;response;sensor;severe mental illness;Signal Transduction;Site;Therapeutic;Time;Tin;tool;Transgenic Mice;Work

PROJECT_TITLE: Molecular and Cellular Determinants of Tolerance to Second Generation Antipsychotics


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Extensive epidemiological evidence links adverse childhood experiences (ACEs) to increased risk for developing alcohol use disorder (AUD) in adulthood. Given that women are more likely to experience multiple forms of ACEs, as well as that the number of women engaging in binge drinking is rapidly increasing, my goal is to define the sex-specific mechanisms by which early life stress enhances alcohol sensitivity and contributes to AUD susceptibility. Focusing on extended amygdala (BNST) neurons expressing the neuropeptide corticotropin- releasing factor (CRF) in a mouse model of early life stress (ELS), I will test the central hypothesis that ELS- enhanced alcohol sensitivity is mediated through increased BNST-CRF neuronal activity, circuit connectivity, and/or neuropeptide release in a sex-specific manner.

PI_NAMEs: MORNINGSTAR, ALLISON REBECCA (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Acute;Adult;adverse childhood events;Alcohol consumption;alcohol effect;alcohol exposure;alcohol response;alcohol sensitivity;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Amygdaloid structure;Anatomy;Anxiety;Attenuated;Behavior;Behavioral;binge drinking;biological adaptation to stress;Biological Assay;biological sex;childhood adversity;Chronic;chronic alcohol ingestion;cohort;Complex;Corticotropin-Releasing Hormone;Data;Development;Diagnosis;Dose;early life stress;Epidemiology;Estrous Cycle;Estrus;experience;experimental study;Exposure to;Female;Fiber;follow-up;Gender;Genetic;girls;Goals;Injections;intraperitoneal;Link;Locomotion;male;Mediating;Mediator;Modeling;Monitor;Motor;Motor Activity;Motor output;mouse model;Mus;neglect;neural circuit;neuromechanism;Neuromodulator;Neurons;Neuropeptides;Output;Pattern;Phenotype;Photometry;Pilot Projects;Predisposition;Reflex action;release factor;response;Rewards;Risk;Risk Factors;sedative;sensor;sex;Sex Differences;sexual dimorphism;Signal Transduction;Staging;Stress;structural determinants;Structure of terminal stria nuclei of preoptic region;Synapses;Techniques;Testing;Viral;Woman

PROJECT_TITLE: Extended amygdala corticotropin-releasing factor circuits mediating sex-specific impacts of early life stress on alcohol sensitivity

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative of the Parent Award Conventional intracellular electrical signaling tools are not designed for sensing cellular activities either at different positions of a single cell or among different cells in a cellular network, which is essential for deciphering the propagative and communicative behaviors of electrogenic cells’ (e.g., neurons) signals and determining the mechanism and treatment of progressive neurological disorders, such as Parkinson’s disease. To overcome these challenges, we propose a 3D array of intracellular sensors featuring a field effect transistor configuration that is highly sensitive, accurate, and scalable to record both intra- and inter-cellular electrophysiological events in a cellular network.

PI_NAMEs: XU, SHENG  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: 3-Dimensional;Alzheimer's Disease;Behavior;Biology;Brain;Calcium Channel;Cardiac;Cardiac Myocytes;cell behavior;Cell membrane;Cell Physiology;Cells;clinical practice;Communication;Dedications;design;Diffusion;Disease;electrical potential;Electronics;Electrophysiology (science);Endocrine;Epilepsy;Episodic ataxia;Event;Functional disorder;Glycocalyx;innovation;insight;Ion Channel;Ion Pumps;Ions;Kinetics;Knowledge;Location;Measures;mechanical properties;Motion;Nervous System Disorder;Neurons;Noise;parent project;Parkinson Disease;Phospholipids;Physiology;Positioning Attribute;Potassium Channel;Resolution;Sampling;Science;sensor;signal processing;Signal Transduction;Sodium Channel;spatiotemporal;Speed;surface coating;System;technology platform;Testing;Time;Tissues;tool;Transistors;voltage

PROJECT_TITLE: Three-dimensional field effect transistor arrays as a platform technology for intracellular electrophysiology recording.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative Learned sound association is the process by which the auditory nervous system associates a sound with a certain outcome, and this ability can be impaired in neurodevelopmental conditions such as language disorder and autism spectrum disorder (ASD). In this proposal, I aim to identify variants and genes affecting language disorder and study the neuronal pathways and circuits involved in sound association along with the mutations that can disrupt them. This will be achieved by using computational approaches to analyze large-scale human genetic data and conducting behavioral experiments with fiber photometry in wildtype and mutant mice models using an interactive virtual reality (VR) environment.

PI_NAMEs: NARAYANAN, SHASHAANK  (contact)

PROJECT_TERMS: Affect;Alleles;Association Learning;Auditory;auditory thalamus;autism spectrum disorder;Aversive Stimulus;Axon;Behavioral;behavioral response;biobank;Candidate Disease Gene;Child;Clinical;Code;cohort;Collection;comorbidity;Corpus striatum structure;Coupled;Cues;Data;Data Set;Dedications;Development;dopaminergic neuron;exome;expectation;experimental study;Family member;Fiber;foot;Foundations;FOXP2 gene;Fright;Gene Expression;General Population;Genes;Genetic;Genetic Risk;genome sequencing;genome wide association study;genomic data;Genomics;Heredity;Heterozygote;High Prevalence;Human Genetics;Impairment;in silico;in vivo;Intelligence;interest;Language;Language Development;Language Disorders;Learning;Link;Longitudinal Studies;loss of function mutation;Measures;Methods;Midbrain structure;Modeling;mouse model;Mus;mutant;mutant mouse model;Mutant Strains Mice;Mutation;Nervous System;Neurodevelopmental Disorder;neuronal excitability;Neurons;Neurosciences;Outcome;Parents;Pathway interactions;Phenotype;phenotypic data;Photometry;Physiological;Physiology;Process;Questionnaires;rare variant;Research;Rewards;Rice;risk variant;Role;Safety;Sampling;Schools;Shock;Site;sound;Speech;statistics;Synapses;synaptic pruning;Tail;Testing;Training;Twin Studies;United Kingdom;Variant;virtual reality environment;Work

PROJECT_TITLE: The genomic and synaptic basis of language disorder and learned sound association


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Pediatric;Prevention;Rare Diseases;Social Determinants of Health;Tuberculosis;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative This award will support the CTU to continue its third decade of high impact, globally relevant HIV and TB prevention and therapeutic research, aligned with Network scientific objectives, and in support of Zimbabwe Ministry of Health policy goals, and designed to advance progress toward UNAIDS 95-95-95 targets. The CTU will help to develop future research aims and disseminate lessons learned to inform local, regional, and international efforts and best practices aimed at changing the trajectory of the HIV pandemic, and ultimately, result in its control.

PI_NAMEs: CHIRENJE, ZVAVAHERA MIKE (contact)

PROGRAM_OFFICER_NAME: GREENFIELD, TERI L

PROJECT_TERMS: Adherence;Adolescent;Adult;AIDS clinical trial group;AIDS prevention;Award;California;Caring;Child;clinical research site;Clinical Trials;Clinical Trials Unit;Communities;community advisory board;community engagement;comorbidity;design;Drug Delivery Systems;Economics;effectiveness evaluation;empowerment;Enrollment;Ensure;Environment;Epidemiology;Evaluation;experience;Female Adolescents;female sex worker;Fortification;Funding;Goals;Health Policy;high risk;HIV;HIV Vaccine Trials Network;HIV/AIDS;HIV/TB;innovation;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;investigator training;Investments;knowledge hub;Laboratories;Lead;men who have sex with men;Mentorship;Methods;multidisciplinary;neutralizing antibody;next generation;novel;novel strategies;pandemic disease;Participant;Pathogenesis;Pharmacy facility;Phase;Policies;Politics;Population;pre-exposure prophylaxis;Prevention;Prevention Research;Prevention strategy;Preventive vaccine;Research;Research Infrastructure;Role;San Francisco;Social Behavior;Technology;Therapeutic;Therapeutic Research;therapeutic vaccine;Training;treatment optimization;Treatment outcome;United States National Institutes of Health;Universities;uptake;vaccine candidate;young woman;Zimbabwe

PROJECT_TITLE: UZ-UCSF CTU


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Women's Health Research

ORG_CITY: Nashville

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE The proposed study will evaluate whether caregivers’ perceived and objective stress are linked to infant’s language development via levels of infant’s exposure to caregiver linguistic input in everyday life. The hypothesized associations will be examined in infants with and without increased familial likelihood for autism and language disorder, as well as a large sample of infants who are recruited from the general population. This project will be the first to more comprehensively assess aspects of stress among caregivers of infants at elevated familial likelihood for autism and has the potential to inform future research and policy, as well as to point towards novel intervention targets intended to support families of infants with and without language learning difficulties.

PI_NAMEs: MARKFELD, JENNIFER E (contact)

PROJECT_TERMS: 3 year old;Affect;Age;Area;Autism Diagnosis;autism spectrum disorder;autistic;autistic children;biological sex;caregiver stress;Caregivers;caregiving;Child;Child Language;Child Rearing;Childhood;Communication;Communities;cost;Data;Diagnosis;diagnostic criteria;Disease;Early Intervention;Economics;Education;experience;Exposure to;Family;family support;Foundations;Funding;Future;General Population;Home environment;improved;indexing;Individual;Individual Differences;individuals with autism spectrum disorder;Infant;infant outcome;innovation;Intervention;Language;language comprehension;Language Development;Language Development Disorders;Language Disorders;language outcome;Learning Difficulty;Life;Linguistics;Link;Measurement;Measures;Modeling;novel;Outcome;Partner Communications;Policies;Population;programs;recruit;Reporting;Research;Research Personnel;Role;Sample Size;Sampling;scaffold;Science;Siblings;skills;social;Social outcome;Societies;Statistical Data Interpretation;Stress;Stressful Event;stressor;Testing;theories;Training;United States;Vocation;Work

PROJECT_TITLE: Evaluating Cascading Effects of Caregiver Stress on Later Language Outcomes of Infants


ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Clustered Protocadherin (Pcdh) genes confer molecular identities to neurons that allow them to determine when they are contacting neuronal branches from the same or different cells. The ability of neurons to distinguish self from non-self is essential to their morphological and physiological development, and accordingly, dysregulation of Pcdh genes has been linked to several neuropsychiatric and neurological disorders. The findings from this proposal will generate a molecular understanding of how Pcdh genes are regulated across neurodevelopment, which could enable the development of therapeutics that remedy the defects in neural wiring seen in these disorders.

PI_NAMEs: BUCKLEY, ALEXANDER  (contact)

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Alleles;Architecture;ATAC-seq;autism spectrum disorder;Bar Codes;Base Pairing;Biological Models;Brain;Brain region;Cell division;Cell surface;cell type;Cells;Chromatin;Chromatin Loop;cohesin;cohesion;combinatorial;Complex;Coupling;Data;Defect;Development;differential expression;Discrimination;Disease;Distal;Enhancers;experimental study;Fluorescent in Situ Hybridization;Gene Cluster;Gene Expression;Gene Expression Regulation;Gene Order;gene repression;Gene Structure;Genes;Genetic;Genetic Transcription;Genome;Genomic DNA;Goals;Heterochromatin;histone methyltransferase;imaging modality;In Vitro;in vivo;in vivo Model;Label;Life;life span;Link;Maps;Measures;Mediating;Memory;Modeling;Molecular;Morphology;Mus;Nervous System Disorder;neural;neural circuit;Neurites;Neurodegenerative Disorders;neurodevelopment;neuron development;Neurons;neuropsychiatric disorder;Neurosciences;Olfactory Epithelial Cell;Olfactory Epithelium;olfactory sensory neurons;Optics;Physiological;Play;postmitotic;Process;promoter;protein complex;Protein Isoforms;reconstruction;Regulation;Resolution;RNA;Role;Schizophrenia;SETDB1 gene;Shapes;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Sister Chromatid;Structure;Synapses;Testing;therapeutic development;Therapeutic Intervention;translational neuroscience;Work

PROJECT_TITLE: How genome architecture controls Protocadherin gene choice at single-allele resolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Z (46)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Duchenne/ Becker Muscular Dystrophy;Muscular Dystrophy;Orphan Drug;Pediatric;Rare Diseases

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: PROJECT NARRATIVE This project aims to reveal mechanisms of communication between skeletal muscle extracellular matrix and the fibroadipogenic progenitor cells that produce progressive fibrotic cycles in muscular disease. The robustness of the fibrotic cycle will be tested by interrupting the pro-fibrotic signaling through clinical gene therapy of the initiating muscle instability. Investigation of these mechanisms and their durability using innovative methodologies in mice and humans with fibrotic muscular dystrophy uncover specific targets for therapies to block and reverse progressive fibrotic pathologies and augment the efficacy of potential gene therapy.

PI_NAMEs: SMITH, LUCAS R (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Address;Architecture;Clinical;Collagen;Collagen Fiber;Communication;Contracture;crosslink;density;design;Diameter;Duchenne muscular dystrophy;Early treatment;Equipment;Extracellular Matrix;Fiber;Fibrosis;gene therapy;Human;Image;innovation;interest;Interruption;Investigation;Measures;mechanical properties;Mechanics;Methodology;micro-dystrophin;Mus;Muscle;muscle stiffness;Muscular Dystrophies;Myopathy;Neuromuscular Diseases;Parents;Pathologic;Pathology;Profibrotic signal;Property;Skeletal Muscle;stem cells;Stretching;System;targeted treatment;Technical Expertise;Tendon structure;Testing;Tissues;trait

PROJECT_TITLE: Dynamic collagen architecture influence on mechanics of dystrophic skeletal muscle


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Microbiome

ORG_CITY: Boulder

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Bacteria within the microbiome are associated with many aspects of health and disease, yet a mechanistic understanding of how these organisms manipulate and contribute to mammalian cell signaling is missing. This supplement extends our understanding by focusing on evolutionary connections between the bacterial and human immune systems. Our findings will allow for development of complementary pre- and probiotic treatments that irradicate harmful bacteria and/or support helpful bacteria to promote human health.

PI_NAMEs: WHITELEY, AARON THOMAS (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Award;Bacteria;Bacteriophages;Biological Assay;Clinical Trials;Complementary therapies;Conflict (Psychology);Cyclic Nucleotides;design;Development;Disease;Evolution;Genes;Goals;gut bacteria;gut microbiome;Health;Horizontal Gene Transfer;Human;Human Microbiome;Immune;Immune response;Immune signaling;Immune system;improved;Mammalian Cell;metagenome;microbiome;Mobile Genetic Elements;novel;nucleotidyltransferase;Oligonucleotides;Organism;Parasites;parent grant;Pathway interactions;Periodicity;prebiotics;Prevalence;probiotic therapy;Probiotics;Proteins;Research;Role;screening;Signal Pathway;Signal Transduction;Stimulator of Interferon Genes;synergism;System;United States National Institutes of Health;Viral;Work

PROJECT_TITLE: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)


ADMINISTERING_IC: DK

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: IRVINE

ORG_NAME: INTEGRATED MEDICAL SENSORS

PHR: Project Narrative IMS has developed the world’s smallest and first integrated electrochemical enzymatic multi-sensor continuous glucose monitor (CGM). The system uses a highly miniaturized (5x smaller than a rice grain) and innovative semiconductor chip (ASIC) with 3 electrochemical sensors (all in their own functionalization wells for independent operation),3 potentiostats, an Analog-to-digital converter (ADC), a multiplexer, and a temperature sensor along with control, power management, and processing circuits. A smallest-in-class external wearable transmitter powers the in vivo sensor and reads data from it via a thin and flexible biocompatible printed circuit board (flex PCB) filament as compared to rigid filaments used in current leading CGMs. The packaged sensor is thinner than a strand of human hair, works for at least 14 days, and is user-insertable and user-removable. We have tested the core platform extensively for the CGM application (30 days swine study, 1-day in- clinic study, 14 days human longevity study). This application is meant to support GMP manufacturing, sterilization and biocompatibility testing as discussed with the FDA to satisfy the requirements for the IDE for FDA 510(k) pivotal trial for an iCGM clearance. IMS CGM ASIC on a US quarter

PI_NAMEs: MUJEEB-U-RAHMAN, MUHAMMAD  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Acceleration;Address;Adoption;Affect;analog;Biochemistry;Biocompatible Materials;biomaterial compatibility;Biosensor;Blood capillaries;Bluetooth;Businesses;Calibration;California;catalyst;Cause of Death;Cellular Phone;Chronic Disease;Clinic;Clinical;Clinical Trials;Coin;commercialization;Compensation;Continuous Glucose Monitor;cost;Data;data streams;Databases;Dedications;design;Devices;diabetes management;Diabetes Mellitus;digital;disability;Doctor of Philosophy;Economics;Electrodes;Electronics;Engineering;Enzymes;Excision;Exercise;fabrication;Family suidae;Feasibility Studies;Feedback;Filament;Fingers;first-in-human;flexibility;flexible electronics;Foreign Bodies;Friends;Glucagon;Glucose;glucose monitor;glycemic control;Goals;Grain;Grant;Hair;Human;human study;Hydrogels;Hypoglycemia;improved;In Situ;in vivo;Industry;Inflammation;innovation;Insulin;integrated circuit;Ketones;Legal patent;Letters;Longevity;manufacture;manufacturing test;Marketing;materials science;Measures;Medical;metal oxide;Methods;Miniaturization;miniaturize;Mission;Modernization;multidisciplinary;Names;nano;Nanotechnology;Needles;Noise;Notification;operation;Pain Free;patient population;Patients;Performance;Persons;Phase;printed circuit board;Privatization;Process;research clinical testing;Research Personnel;response;Rice;Scientist;Seasons;Secure;Semiconductors;sensor;sensor technology;service providers;Signal Transduction;Site;Skin;skin irritation;Skin Tissue;Sleep;Sterilization;subcutaneous;System;Techniques;Technology;Temperature;Testing;Texture;Thinness;Time;Tissues;Traction;user-friendly;Visualization;wearable device;Weight;wireless communication;Work

PROJECT_TITLE: Optimizing A Miniaturized and Integrated Continuous Glucose Monitoring Platform

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (19)]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: VOLO

ORG_NAME: ILLINOIS ENVIRONMENTAL HEALTH ASSOCIATION

PHR: FDA Support for Conferences and Scientific Meetings Funding Opportunity Announcement (FOA) Number: PAR-23-072  Participant: Illinois Environmental Health Association  Program Dates: July 2024- December 2024 Project Summary/ Narrative The purpose of this project is to provide the Illinois Environmental Health Association with financial assistance to conduct a high-quality conference in the Midwest, specifically, Illinois. Illinois was chosen as the host for the 2024 FDA Retail Food Protection Seminar. The benefit of this project is to provide a location in the Midwest for Illinois and surrounding states to come together to discuss retail food, food safety, retail food program standards, and many other environmental health topics while networking with other jurisdictions.

PI_NAMEs: YATES, ANNA MARIE (contact)

PROGRAM_OFFICER_NAME: HEAD, DANIELLE

PROJECT_TITLE: 2024 FDA Retail Food Protection Seminar and Illinois Environmental Health Association’s Annual Education Conference

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 ORA-T (06)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

PHR: Vascular dysfunction and calcification are common in CKD and associated with progression to end-stage renal disease, cardiovascular disease, and death. The current proposal will examine the association of abundant circulating bile acids, including deoxycholic acid, a secondary bile acid that is elevated in CKD and linked with endothelial cell toxicity, vascular dysfunction, and vascular calcification, with cardiovascular disease events and all-cause mortality across a full range of kidney function. Because deoxycholic acid levels are potentially modifiable, they may be a target for intervention to reduce vascular dysfunction and calcification, cardiovascular disease events, and death in CKD.

PI_NAMEs: JANI, ALKESH HARIHAR (contact)

PROJECT_TERMS: adjudication;Affect;Aorta;arterial stiffness;Bile Acids;blood pressure control;blood pressure intervention;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cessation of life;Chenodeoxycholic Acid;Cholic Acids;Chronic Kidney Failure;Clinical;Clinical Trials;cohort;cooperative study;coronary artery calcification;Cross-Sectional Studies;Data;Deoxycholic Acid;Dialysis procedure;Diet;Disease Outcome;End stage renal failure;endoplasmic reticulum stress;Endothelial Cells;endothelial dysfunction;Enrollment;Epidemic;Epidemiology;Event;Exercise;Glomerular Filtration Rate;gut bacteria;Homocysteine;improved;Individual;Intervention;Intervention Trial;Kidney Diseases;Link;Lithocholic Acid;Measures;mortality;novel;Observational Study;Outcome;Participant;participant enrollment;Patients;Physiologic pulse;Plasma;Population;Premature Mortality;Prevalence;Public Health;randomized trial;Renal function;Risk Factors;Risk Marker;Sampling;Serum;Smooth Muscle Myocytes;Toxic effect;United States;Vascular calcification;Vascular Diseases;Vascular Smooth Muscle;Veterans

PROJECT_TITLE: Deoxycholic Acid and Outcomes across Stages of Chronic Kidney Disease


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Implanted medical devices in the central nervous system (CNS) are used for a number of current and future applications including control of tremor (Parkinson’s disease, ~60,000 Veterans†), pain block/relief (chronic pain, >30 million US†), shunting cerebrospinal fluid (hydrocephalous, ~24,000 Veterans†), and brain-controlled prostheses (spinal cord injury paralysis, ~50,000 Veterans†), among others (†: prevalence). Chronic inflammation may reduce the longevity and performance of CNS-implanted devices. The proposed research plan focuses on advancing one such technology, intracortical microelectrodes for brain-computer interface (BCI) controlled prostheses, which are particularly sensitive to inflammation. The project seeks to mitigate the inflammatory response to enable long-term use of BCI microelectrodes to restore functional limb movement and improve quality of life for paralyzed Veterans.

PI_NAMEs: CAPADONA, JEFFREY R;SHOFFSTALL, ANDREW  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Amputation;animal imaging;Anterior;Anti-Inflammatory Agents;Antibiotics;Behavior;behavior test;Behavioral;Bilateral;Biological;Blood;Blood Chemical Analysis;Blood Platelets;Blood Vessels;blood-brain barrier permeabilization;Body Weight;Brain;brain computer interface;Central Nervous System;Cerebrospinal fluid shunts procedure;Chronic;chronic pain;Cicatrix;cohort;commercialization;Data;delivery vehicle;Devices;Dexamethasone;dosage;Dose;Drug Delivery Systems;Drug Targeting;Drug usage;Electrodes;Engineering;Euthanasia;Failure;FDA approved;fluorescence imaging;Frequencies;functional restoration;Future;Gender;Gene Expression;Glucocorticoids;Goals;Health;Hemorrhage;Hemostatic function;High Pressure Liquid Chromatography;Human;imaging modality;Implant;implantable device;implantation;Implanted Electrodes;improved;Inflammation;Inflammatory Response;Kidney;Kinetics;Left;limb movement;Limb Prosthesis;Liver;Local Therapy;Longevity;Lung;Measurement;Measures;Mechanics;Mediating;Medical Device;medical implant;Medical Research;Metabolic Clearance Rate;Methods;Microelectrodes;Motor;Motor Cortex;nanolabel;nanoparticle;Nerve Degeneration;neural;neuroinflammation;neuromuscular;Neurons;Organ;Outcome;Pain;Paralysed;Parkinson Disease;Patients;Pattern;Performance;Peripheral;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Pharmacotherapy;Prevalence;prevent;Prosthesis;Quality of life;Randomized;Rattus;Rehabilitation therapy;Research;Research Personnel;response;Rodent;Rodent Model;Safety;safety assessment;Saline;sensor;Side;side effect;Signal Transduction;Silicon;Site;Spinal cord injury;Spleen;Steroids;Stroke;System;Technology;Therapeutic Agents;Thinking;Time;tissue processing;Tissues;Touch sensation;Trauma;treatment comparison;Treatment Efficacy;Tremor;Veterans;With laterality

PROJECT_TITLE: Optimizing Delivery of a Known Therapeutic Agent, Dexamethasone, to Improve Microelectrode Recording Performance

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: TUSCALOOSA

ORG_NAME: TUSCALOOSA VETERANS AFFAIRS MEDICAL CTR

ORG_STATE: AL

PHR: Older adults have been disproportionately impacted and distressed by the COVID-19 pandemic. Social distancing and stay-at-home orders have increased older adults’ risk of social isolation and loneliness that will has led to a pandemic-induced fear of being in close proximity to other people. These fears and avoidant behaviors will have lasting effects if not treated with effective, safe, and convenient psychological interventions. This study will evaluate the acceptability and feasibility of delivering a small group intervention, called Acceptance and Commitment Therapy (ACT), through a telehealth modality to Veterans ages 65 and older who are experiencing pandemic-related emotional and physical distress. ACT helps decrease emotional suffering, improve well-being and promote positive behavior change by increasing one’s psychological flexibility through the practice of mindfulness, acceptance, and values-based behaviors. The knowledge gained from this study will be used to better tailor the invention to meet the needs of older Veterans in an era of post-pandemic recovery.

PI_NAMEs: DAVIS, LORI L. (contact)

PROJECT_TERMS: acceptability and feasibility;Accounting;Address;Adult;Affect;Aftercare;age group;Aging;Anxiety;arm;Attention;Behavior;behavior change;Behavioral;behavioral health;chronic pain;Climacteric;Clinical;Cognitive Therapy;cohort;coping;Coping Skills;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 susceptibility;Data;Data Collection;design;Development;Diagnosis;Distress;effective therapy;Effectiveness;Effectiveness of Interventions;electronic data;Emotional;emotional distress;Enrollment;evidence base;experience;Feedback;flexibility;follow-up;Fright;Functional impairment;group intervention;Health;human old age (65+);Impairment;improved;improved outcome;infancy;Infection;Influenza vaccination;insight;Intervention;invention;Knowledge;Label;late life;Life;Loneliness;loved ones;male;Measures;Medical;medical appointment;Mental Depression;Mental Health;Method Acceptability;Methods;military veteran;mindfulness;Modality;Modeling;Morbidity - disease rate;mortality;Nutritional;older adult;Outcome;Outcome Measure;pandemic disease;pandemic impact;pandemic stressor;Participant;Personal Satisfaction;Persons;Pilot Projects;pilot trial;Population;post-pandemic;Prevention Measures;Procedures;Protocols documentation;psychiatric comorbidity;psychologic;Psychological Impact;psychosocial;psychosocial outcome;Quality of life;Quasi-experiment;Randomized;Randomized, Controlled Trials;Recovery;Rehabilitation therapy;Research;Research Personnel;research study;Risk;Risk Factors;Sampling;SARS-CoV-2 exposure;Schedule;Science;Self Efficacy;skills;social;Social Distance;Social isolation;stay-at-home order;Suicide;suicide rate;telehealth;timeline;treatment effect;United States;Veterans;Virus;Well in self;willingness

PROJECT_TITLE: Pandemic Acceptance and Commitment Therapy (Pan-ACT): Feasibility and Acceptability of Telehealth Delivery with Older Veterans

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Cancer incidence is expected to increase to 23.6 million by 2030 worldwide, and cancer is the leading cause of death for Asian Americans whose numbers are rapidly rising to reach 40 million by 2050. Despite instances of greater cancer-specific mortality compared to other Asians and likely limited access to high-quality care due many experiencing language barriers (~50%), very little is known about supportive care needs in Chinese-, Vietnamese-, and Korean-Americans with metastatic cancers. This project will fill a critical gap in our understanding, and develop culturally relevant and scalable psychosocial resources aimed at improving the quality of life of Chinese-, Vietnamese-, and Korean-Americans with metastatic cancers.

PI_NAMEs: KIM, JACQUELINE H. J. (contact)

PROGRAM_OFFICER_NAME: ACEVEDO, AMANDA MARIE

PROJECT_TERMS: active method;Adult;Advocacy;Agreement;American;Area;Asian;Asian Americans;Asian population;Behavioral;California;cancer care;Cancer Control;Cancer Etiology;Cancer Patient;cancer survival;care delivery;care outcomes;career;Caregivers;Caring;Cause of Death;Chinese;Collaborations;Communication;Competence;coping;cultural values;Data;demographics;design;Development;Diagnosis;Disease;Disseminated Malignant Neoplasm;Early Diagnosis;East Asian;Emotions;Ethnic Population;experience;Faculty;Family;Focus Groups;Fostering;Functional impairment;Future;Goals;Guidelines;Hispanic;Immigrant;improved;improved outcome;Incidence;informant;innovation;Intervention;Interview;Knowledge;Korean American;Koreans;Language;Latinx;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Medical;Mentorship;Methods;Modality;mortality;Not Hispanic or Latino;Oncology;Outcome;Participant;Patient Outcomes Assessments;Patients;Persons;Phase;Philosophy;Population;Positioning Attribute;preference;Process;Provider;psychosocial;psychosocial resources;Qualifying;Quality of Care;Quality of life;Randomized, Controlled Trials;Research;Research Methodology;Research Personnel;Resource Development;Resources;response;skills;social;southeast Asian;Structure;Supportive care;Surveys;Survival Rate;survivorship;Symptoms;tenure track;Testing;therapy development;Training;Vietnamese;Work;Writing

PROJECT_TITLE: Supportive Care Needs in Asian Americans with Metastatic Cancer


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative This project is relevant to public health because it addresses a novel mechanism by which interactions of aggressive cancers such as acute myeloid leukemia (AML) with their niche can promote disease progression. If successful, this work will provide a scientific basis for development of new strategies to treat these aggressive cancers with less than 25% survival rates. This is highly relevant to the NIH mission of developing fundamental knowledge to help reduce the burdens of human disability.

PI_NAMEs: BAJAJ, JEEVISHA  (contact)

PROGRAM_OFFICER_NAME: SAYYED, ZULEKHA I

PROJECT_TERMS: Activities of Daily Living;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Adhesives;adult stem cell;Blast Phase;Bone Marrow;cancer cell;Cell Death;Cell Line;Cell surface;Cells;Chronic Myeloid Leukemia;comparison control;CRISPR screen;Data;Data Set;Development;disability;Disease;disease model;Disease Progression;Endothelial Cells;Environment;Enzymes;Genes;Genetic;genome-wide;Goals;Growth;Growth Factor;Hematopoiesis;Hematopoietic stem cells;Human;Impairment;In Vitro;in vivo;interest;knock-down;Knowledge;leukemia;Leukemic Cell;leukemic stem cell;leukemogenesis;Malignant Neoplasms;Mediating;Mission;MLL-AF9;mouse model;Mus;Mutation;Myelogenous;Myeloid Leukemia;myeloid leukemia cell;Myeloproliferative disease;new therapeutic target;Non-Essential Amino Acid;novel;Oncogenes;Osteoblasts;osteogenic;osteoprogenitor cell;Patients;Pilot Projects;Prognosis;Proliferating;Public Health;Receptor Signaling;reconstitution;Resistance;Role;self-renewal;Signal Transduction;single-cell RNA sequencing;small hairpin RNA;stem cell self renewal;stem cells;Stromal Cells;Surface Antigens;Survival Rate;Taurine;taurine transporter;Testing;The Cancer Genome Atlas;therapy resistant;transcriptome sequencing;United States National Institutes of Health;Work;Xenograft Model

PROJECT_TITLE: Targeting Microenvironmental Signals in Myeloid Malignancies

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Tuberculosis;Women's Health Research

ORG_CITY: PARKTOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: WITS HEALTH CONSORTIUM (PTY), LTD

PHR: 8. Project Narrative The Wits HIV Research Group Clinical Trials Unit (WHRG CTU) consists of four pleuripotent Clinical Research Sites-The Wits Helen Joseph Hospital CRS, The Wits RHI Shandukani Maternal and Child CRS, Wits RHI Hillbrow Health Precinct Ward 21 CRS and the Wits RHI Research Centre. The WHRG CTU research agenda includes HIV treatment, HIV-associated infections and HIV-related cancers; HIV prevention; TB treatment and prevention (including MDR-TB) and Hepatitis. The CTU conducts research across key populations, including adolescent girls and young women, men who have sex with men, transgender populations and female sex workers; as well as vulnerable populations such as neonates, infants, older children, pregnant and breastfeeding women to a high standard of quality, which has been recognized locally and internationally.

PI_NAMEs: REES, HELEN ;SANNE, IAN MATTHIAS (contact)

PROGRAM_OFFICER_NAME: COATES, CINDY KAREN

PROJECT_TERMS: Administrative Supplement;Adolescent;Adult;AIDS clinical trial group;AIDS prevention;antiretroviral therapy;Blinded;Breast Feeding;Child;clinical research site;Clinical Trials Cooperative Group;Clinical Trials Unit;Collaborations;Communities;community engagement;Conduct Clinical Trials;Contracts;data management;Ensure;Equipment;experience;Female Adolescents;female sex worker;Health;Hepatitis;high risk;high standard;HIV;Hospitals;Infant;Infection;Infusion procedures;Injectable;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Investigational Drugs;Joints;Laboratories;Leadership;Malignant Neoplasms;men who have sex with men;Mentors;microbicide;Monoclonal Antibodies;Multidrug-Resistant Tuberculosis;neonate;Oral;Persons;Pharmacy facility;Phase;Population;population based;pregnant;Pregnant Women;Prevention;Process;randomized trial;recruit;Research;Site;South Africa;Testing;Training;transgender;tuberculosis treatment;United States National Institutes of Health;Vaccines;VTN gene;Vulnerable Populations;ward;Wit;Woman;young woman

PROJECT_TITLE: Wits HIV Research Group CLINICAL TRIAL UNIT (CTU) Administrative supplement - COP18


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE By integrating state-of-the-art T cell characterization in circulation, atherosclerotic lesions, and the kidney in humans with T1D, our project aims to bridge significant gaps in understanding CVD pathogenesis in T1D. Leveraging the CaRe-T1D biobank and multidisciplinary approaches, our research is poised to offer transformative insights, potentially revolutionizing T1D care and opening new therapeutic avenues across the cardio-renal axis.

PI_NAMEs: BJORNSTAD, PETTER ;BORNFELDT, KARIN E. (contact);VAISAR, TOMAS

PROGRAM_OFFICER_NAME: RAJAPAKSE, NISHADI

PROJECT_TERMS: Acceleration;Adherence;Adhesions;advanced analytics;analytical tool;Arterial Fatty Streak;Atherosclerosis;Beta Cell;biobank;Biology;biomarker identification;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Caring;CD8-Positive T-Lymphocytes;Cell Adhesion;cell preparation;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Circulation;Clonal Expansion;Clone Cells;comparative;Complex;Complications of Diabetes Mellitus;Coronary artery;coronary lesion;Cytotoxic T-Lymphocytes;Data;design;Development;Diabetes Mellitus;Diabetic Nephropathy;Digit structure;Endothelial Cells;Endothelium;Ensure;Event;Experimental Designs;Family;Funding;Gene Silencing;Glycolysis;holistic approach;Human;Immune;Immune response;Immunology;In Vitro;Individual;Injury to Kidney;insight;Insulin;Insulin-Dependent Diabetes Mellitus;interdisciplinary approach;Intervention;Kidney;Lesion;Lesion by Stage;Link;Metabolic;Methodology;migration;Morphology;mortality;mouse model;multiple omics;Necrosis;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Participant;Pathogenesis;Pathway interactions;Peripheral Blood Mononuclear Cell;Physicians;Play;Population;Positioning Attribute;Process;Proteins;proteomic signature;Proteomics;recruit;Research;Resources;Role;Sampling;Scientist;Severities;T cell receptor repertoire sequencing;T-Lymphocyte;Testing;therapeutic target;Tissues;transcriptomics

PROJECT_TITLE: Immunometabolism and the Cardio-Renal Axis in T1D-associated Atherosclerosis: Insights from the CaRe T1D Biobank

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-T (O1)]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Despite its significant health care burden, no targeted therapies are available for the treatment of Fragile X Syndrome and specifically the autism spectrum disorder-related behaviors in Fragile X Syndrome, as the mechanisms underlying these disorders remain poorly understood. In this proposal we will delineate the cerebellar contribution to autism-relevant behaviors in Fragile X Syndrome and delineate the underlying mechanisms and therapeutic benefits of cerebellar genetic and circuit-based strategies to improve autism- relevant behaviors in multiple mouse models for Fragile X Syndrome.

PI_NAMEs: TSAI, PETER T. (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Acute;Applications Grants;association cortex;autism spectrum disorder;Automobile Driving;Behavior;Behavior Disorders;Behavioral;Cell Physiology;Cerebellar Diseases;Cerebellum;Child;Data;Decision Making;Development;disability;Disease;Electrophysiology (science);Evaluation;eyeblink conditioning;Fragile X Syndrome;Functional disorder;Genetic;Genetic Models;Healthcare;healthcare burden;Hypersensitivity;Image;Impairment;improved;in vivo;Individual;Injections;Knock-out;Lifestyle-related condition;Link;Lobule;Mediating;Modeling;Molecular;molecular targeted therapies;Morphology;mouse model;mutant;mutant mouse model;Mutant Strains Mice;mutation carrier;Nervous System Physiology;neural;Neurocognitive;Neurodevelopmental Disorder;neuroregulation;Parietal;Pathogenesis;Pathology;Pathway interactions;Phenotype;Physiology;Play;pre-clinical;Prevalence;Purkinje Cells;Regulation;restoration;Role;Sensory;Slice;social;social deficits;Subcellular Anatomy;Synaptic plasticity;targeted treatment;Therapeutic;therapy development;Tremor/Ataxia Syndrome;United States;Viral

PROJECT_TITLE: Cerebellum and cerebellar-regulated circuit contribution to Fragile X Syndrome

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Cancer

ORG_CITY: LA JOLLA

PI_NAMEs: SIMEONE, DIANE M (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Accounting;Adherence;Advisory Committees;anti-cancer research;Budgets;California;Cancer Center;Cancer Center Support Grant;Catalogs;Clinic;Clinical;Clinical Research;Collaborations;collaborative environment;Communication;Communities;Contracts;cost effective;Decision Making;Development;Ensure;Equipment;Evaluation;Event;Fostering;Future;Goals;Grant;Grant Review;Guidelines;Health Sciences;Human Resources;improved;Information Services;Information Technology;Infrastructure;Institution;Leadership;Maintenance;Malignant Neoplasms;meetings;member;Mission;Monitor;Occupational activity of managing finances;operation;Participant;Patient Care;payment;Personnel Management;Policies;Population;Procedures;Process;Program Research Project Grants;programs;recruit;Research;Research Personnel;Resource Allocation;Resource Sharing;Resources;Review Committee;Running;Services;skills;Specialist;Systems Development;Technology;technology development;Technology Transfer;Universities;Vision;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Prevention

PI_NAMEs: NGUYEN, QUYEN  (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;Basic Science;Biology;Cancer Biology;cancer care;Cancer Center Support Grant;Cancer Patient;cancer prevention;cancer therapy;career;career development;Clinical;Clinical Research;Clinical Sciences;Communities;community collaboration;community engagement;Community Health;Community Healthcare;Community Outreach;community partners;Complement;Continuing Education;continuing medical education;Degree program;Detection;Development;Discipline;Disparity;Doctor of Philosophy;Education;education research;Environment;Faculty;faculty mentor;Fellowship;Fostering;Funding;Future;Goals;Graduate Education;graduate student;Grant;Hand functions;Health;Health Personnel;Health Professional;Healthcare;high school;Individual;innovation;Institution;interest;Laboratories;Letters;Malignant Neoplasms;Medical;medical schools;Medical Students;Mentors;Mentorship;Mission;multidisciplinary;NCI-Designated Cancer Center;next generation;novel;novel therapeutic intervention;Performance;Persons;Phase;Population Sciences;Postdoctoral Fellow;pre-clinical;Prevention;programs;Quality of life;Research;Research Institute;Research Personnel;Research Training;Science;Scientist;Series;skills;social media;Students;support network;symposium;Talents;Training;Training Activity;Training and Education;training opportunity;Training Programs;Translating;Translational Research;undergraduate student;Underrepresented Minority;underserved minority;Universities;web platform;web site;Writing

PROJECT_TITLE: Cancer Research Career Enhancement and Related Activitites