ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Rare Diseases

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: PROJECT NARRATIVE Orofacial clefts are one of the most common structural birth defects with an average incidence of 1 in 700 newborns. Components of the Wnt signaling pathway, including the frizzled receptors, have been shown to be necessary for normal palatal development, and mutations in one of these genes, Frizzled 2, have been associated with congenital disorders affecting craniofacial development. The objective of this proposal is to determine how mutations in Frizzled 2 affects the developing palate to ultimately support the development of novel therapeutic approaches.

PI_NAMEs: MICHALSKI, MEGAN  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Affect;Alleles;autosome;beta catenin;Biological Assay;Birth;Breeding;Bromodeoxyuridine;career development;Cell Differentiation process;cell fate specification;Cell Lineage;cell motility;Cells;Cephalic;Chemotactic Factors;Cleft Lip;cleft lip and palate;Cleft lip with or without cleft palate;Cleft Palate;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Congenital Abnormality;Congenital Disorders;Control Animal;Craniofacial Abnormalities;craniofacial development;Data;Development;directional cell;Disease;Embryo;Embryonic Development;Epithelial Cells;Failure;Family;Foundations;Future;FZD2 gene;Gene Targeting;Genes;Genetic;Genetic Transcription;genome editing;Goals;Healthcare Systems;Heterozygote;Histology;Homozygote;Human;improved;In Situ Nick-End Labeling;In Vitro;Incidence;Intervention;Ligands;Limb structure;Link;Live Birth;LoxP-flanked allele;Mammalian Oviducts;Mediating;Membrane;Mesenchyme;microCT;migration;Missense Mutation;Modeling;Molecular;Morphology;mouse model;Mus;mutant;Mutation;Neural Crest Cell;new technology;Newborn Infant;Nonsense Mutation;novel therapeutic intervention;nucleic acid delivery;Open Reading Frames;orofacial cleft;palatal shelves;Palate;palatogenesis;Pathway interactions;Patients;Pattern;Phenotype;planar cell polarity;Play;prevent;Process;programs;Publishing;Rare Diseases;receptor;Regulation;Reporter;Research;response;Robinow syndrome;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Solid;Structural Congenital Anomalies;Syndrome;targeted treatment;Testing;Tissues;Transgenes;Variant;WNT Signaling Pathway;WNT5A gene

PROJECT_TITLE: Deciphering the Role of Frizzled Receptors in Palatal Development

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MAYWOOD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: Project Narrative  These studies investigate the mechanisms by which contractility is generated by myosin 2 motor proteins. We now appreciate a multi-step system to build contractile actomyosin2 systems that are required to produce physiological levels of contractility. Provided that generating and optimizing levels of contractility is required throughout cell and developmental biology, the insights gained from this proposal into the molecular mechanisms by which cells contract has far reaching implications.

PI_NAMEs: BEACH, JORDAN  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actomyosin;Biological Assay;Cell Physiology;Cells;Cellular biology;Contracts;Developmental Biology;Event;Filament;high resolution imaging;In Vitro;insight;Investigation;light microscopy;Molecular;Morphogenesis;Motor;Movement;Myosin S-2;Physiological;Proteins;Structure;System;temporal measurement;Time;Tissues;Work

PROJECT_TITLE: Mechanisms of Contractile Network Assembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Alzheimer’s Disease (AD) is the leading cause of dementia in the United States and currently has no effective therapies that target tau aggregation, one of the core pathological hallmarks of AD. My goal is to understand how structurally disordered low complexity (LC) regions of RNA-binding proteins modify tau aggregation. I will define the importance of LC domains as a mediator of tau aggregation and a potential therapeutic target.

PI_NAMEs: SHAPLEY, SARAH  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Amyloid beta-Protein;Arginine;Binding;Biochemical;Bioinformatics;Biological Assay;Biotinylation;Brain;brain tissue;career;Cell Communication;Cell Culture Techniques;Cell Fractionation;Cell model;Cells;Chronic;Clinical;Cytoplasm;Dementia;Deposition;Detergents;Disease;effective therapy;Electron Transport;Embryo;enhancing factor;experimental study;extracellular;gain of function;Goals;Human;Image;Impaired cognition;in vitro Assay;insight;Intervention;Kidney;Kinetics;Label;Length;loss of function;Mammalian Cell;MAPT gene;Mass Spectrum Analysis;Mediating;Mediator;Microtubules;Nerve Degeneration;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;Neurons;new therapeutic target;novel;overexpression;paired helical filament;Pathogenicity;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Persons;Play;Process;protein aggregation;Proteins;Proteome;Proteomics;recombinant RNA;Reporter;Research;Research Personnel;RNA;RNA Recognition Motif;RNA Splicing;RNA-Binding Proteins;Role;self assembly;Senile Plaques;Serine;Severities;Solubility;Structure;Symptoms;System;targeted treatment;tau aggregation;tau Proteins;Tauopathies;Techniques;Testing;Therapeutic Intervention;therapeutic target;Training;Transmission Electron Microscopy;United States;Western Blotting

PROJECT_TITLE: Investigating the role of Serine Arginine (SR)-Rich RNA Binding Proteins in Tau Aggregation


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Enhancer RNAs (eRNAs), a large category of noncoding RNAs transcribed from regulatory enhancer regions, exhibit high cell type- and status-specificity in human cells and therefore represent promising disease biomarkers or new therapy targets. However, our mechanistic understanding of eRNAs in normal biological process or during disease development remains limited. In this proposal, we will develop new approaches to elucidate unappreciated eRNA and protein complexes that function in gene control and genome organization, which will have strong mechanistic implications to understand many enhancer-mediated human diseases, such as cancer, inflammation and neurodegeneration.

PI_NAMEs: LI, WENBO  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 3-Dimensional;Address;Architecture;Binding;Biochemical;Biological;Biological Markers;Biological Process;Biophysics;Bromodomain;Categories;Cell Nucleus;cell type;Cells;Chemicals;ChIP-seq;Complex;Data;Development;Disease;DNA;DNA-Binding Proteins;Drug Targeting;Elements;Enhancers;ESR1 gene;Etiology;Exhibits;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Genomics;Goals;Health;Hi-C;Human;human disease;Immune System Diseases;improved;in vivo;Inflammation;inhibitor;insight;Malignant Neoplasms;Mammalian Cell;Mediating;Methods;Methylation;Modification;Molecular;Mutation;Nerve Degeneration;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Pathogenesis;Pathologic;Phase;Physical condensation;Physiological;Play;Precision Run-On Sequencing;programs;protein complex;protein degradation;Proteins;recruit;Regulation;Research;Ribonucleoproteins;risk variant;RNA;RNA Binding;RNA Sequences;RNA-Binding Proteins;RNA-Protein Interaction;Role;Specificity;SS DNA BP;Structure;success;targeted treatment;Testing;Therapeutic;Transcript;transcription factor;Transcriptional Regulation;Untranslated RNA;Work

PROJECT_TITLE: Mechanisms Underlying Enhancer Rnp Mediated Gene Regulation And Genome Organization

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

PHR: PROJECT NARRATIVE Compared to nucleic acids, proteins are more effective biomarkers that directly reflect cellular states and dynamic changes. However, many cellular proteins with important functions in gene regulation and signalling, and many disease biomarkers, are expressed at low abundance, preventing them from faithful detection by mass spectrometry in single cells and clinical samples. A technology that is capable of high-throughput, unbiased protein detection in an unknown complex sample, and with single-molecule sensitivity will enable in-depth proteomic studies in small clinical samples and detection of rare disease biomarkers, and broadly transform the practice from biomedical research to diagnostics and therapeutics of various diseases.

PI_NAMEs: DAI, MINGJIE  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: 2019-nCoV;Affinity;Aging;Amino Acids;Antibody Specificity;Award;Bar Codes;Basic Science;Binding;Biochemistry;Bioinformatics;Biological Markers;biological research;Biological Response Modifier Therapy;Biomedical Research;biophysical analysis;biophysical techniques;Biopsy Specimen;Biotechnology;Body Fluids;Cell Culture Techniques;Cell Separation;Cells;Clinical;Complex;Complex Mixtures;Computer Analysis;Computing Methodologies;Cytolysis;Data Analyses;Detection;detection limit;detection method;detection sensitivity;Development;Diagnostic;Disease;DNA;emerging pathogen;Future;Gene Expression Regulation;Goals;High-Throughput DNA Sequencing;Human;Image;Immobilization;Immunology;innovation;Knowledge;Label;Lead;liquid biopsy;Malignant Neoplasms;Mass Spectrum Analysis;Mechanics;Membrane Proteins;Mentors;Methods;Microfluidics;Microscopy;miniaturize;Mitochondria;Modeling;Modification;Molecular;molecular imaging;Nerve Degeneration;new technology;novel;Nucleic Acids;Optics;Organelles;Outcome;Peptides;precision medicine;Preparation;prevent;programs;protein profiling;Proteins;Proteome;Proteomics;Rare Diseases;Research;Resolution;Sampling;Scientist;Signal Transduction;single cell sequencing;single molecule;skills;superresolution microscopy;Surface;Technical Expertise;Techniques;Technology;technology platform;Therapeutic;tool;Training;ultra high resolution;Vertebral column;Vision

PROJECT_TITLE: Single-molecule protein identification and single-cell proteomics


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Complementary and Integrative Health;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Natural Products;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative: The fatality rate of legionnaires disease is about 10% due to complications and about 25% for those infected in the healthcare facility. The proposed research aims to 1) identify the chemical structure and bioactivity of natural products produced by the human pathogen Legionella and 2) characterize two novel enzymes involving the biosynthesis of the potential pharmacophore of the natural products. This work will provide a viable workflow to identify and characterize novel natural products or potential virulent factors produced by human pathogens to combat the increasing microbial pathogen infection.

PI_NAMEs: CUI, ZHENG  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Acute;Affect;Anabolism;bioactive natural products;Bioinformatics;Biological;Biological Assay;biomarker identification;Chemical Structure;combat;Cytotoxic agent;design;drug candidate;Emerging Communicable Diseases;Enzymes;Fatality rate;Fever;fighting;Gene Cluster;Gene Expression;Gene Targeting;Genes;Health care facility;Homologous Gene;Host Defense;human pathogen;Impairment;Infection;inhibitor;Investigation;knockout gene;Legionella;Legionella pneumophila;Legionellosis;Legionnaires' Disease;Mediating;Medicine;metabolomics;metalloenzyme;Microbial natural product;mutant;Natural product discovery;Natural Products;Nature;Neighborhoods;Nitrites;Nitroreductases;novel;Organism;Outcome;pathogenic microbe;Pathway interactions;pharmacophore;Play;Prodrugs;Proteins;Reaction;Research;Resistance;Role;secondary metabolite;small molecule;Source;Substrate Specificity;Testing;Time;Virulence;Virulent;Work

PROJECT_TITLE: Natural product discovery and biosynthetic pathway elucidation from the human pathogen Legionella


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Stroke

ORG_CITY: SEATTLE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative This study will investigate the relationship between 3D wall enhancement and geometric features and intracranial aneurysms volume growth. This information will be a basis for future larger scale multi-center studies. The project will provide insight into the underlying mechanisms of aneurysm progression and help in guiding treatment for this devastating condition.

PI_NAMEs: ZHU, CHENGCHENG  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: 3-Dimensional;Acceleration;Age;American Heart Association;Aneurysm;Angiography;automated segmentation;Blood;Cessation of life;Characteristics;clinical imaging;clinical practice;clinical predictive model;contrast enhanced;Development;Digital Subtraction Angiography;Evaluation;experience;follow-up;Future;Geometry;Growth;Guidelines;high risk;Image;Image Analysis;imaging modality;Imaging Techniques;improved;In Vitro;in vivo evaluation;inflammatory marker;insight;Intervention;Intracranial Aneurysm;Investigation;Machine Learning;Magnetic Resonance Imaging;Manuals;Measurement;Measures;Meta-Analysis;Methods;Microsurgery;Morbidity - disease rate;Morphologic artifacts;mortality;Multicenter Studies;Neurologic Deficit;Operative Surgical Procedures;Patients;Population;Predictive Factor;Predictive Value;prevent;quantitative imaging;radiomics;Reader;Recommendation;recruit;Resolution;Risk;Rupture;Scanning;Shapes;Surrogate Markers;surveillance imaging;Techniques;Testing;Time;Training;Validation

PROJECT_TITLE: Investigation of the quantitative intracranial aneurysm wall enhancement and geometric features associated with aneurysm volume growth

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Cystic Fibrosis;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Progress in improving infection outcomes depends upon understanding factors that diminish antibiotic activity. This proposal focuses on population-level resistance heterogeneity and unstable resistance as these phenotypes confound standard susceptibility testing and reduce antibiotic efficacy. Work to define extent of these phenotypes, their effects on susceptibility testing and treatment responses, and their genetic mechanisms could lead to new personalized medicine approaches to select antibiotics, and identify new strategies to improve antibiotic efficacy.

PI_NAMEs: SINGH, PRADEEP K (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Accounting;Affect;Antibiotic Therapy;Antibiotics;Bacteria;Bacterial Infections;Cells;Chronic;Clinical;clinical effect;clinical predictors;Clinical Research;cohort;Compensation;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis sputum;Data;density;Disease;Exhibits;fitness;Future;Gene Amplification;Generations;Genetic;Growth;Heterogeneity;improved;improved outcome;in vivo;Individual;Infection;Infrastructure;Inhalation;Intermediate resistance;Knowledge;Link;Measurement;Measures;Mendelian disorder;Methods;Mutation;Organism;Outcome;pathogen;Patients;personalized medicine;Persons;Phenotype;Point Mutation;Population;Population Study;precision medicine;Predictive Factor;Predisposition;preservation;Prevalence;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;pulmonary function;Research Infrastructure;Resistance;Respiratory Signs and Symptoms;response;Site;Specimen;Sputum;Testing;Time;Tobramycin;Treatment Failure;Treatment outcome;Treatment Protocols;treatment response;Work

PROJECT_TITLE: Prevalence, Consequences and Mechanisms of Antibiotic Heteroresistance in Cystic Fibrosis

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: Aurora

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE: Regulation of Salmonella gene expression is essential for the disease-promoting interactions that this pathogen establishes with human hosts. We have discovered that previously unknown protein- protein interactions of the ancestral protein thioredoxin with transcription factors regulate key steps of Salmonella pathogenesis. The proposed investigations will characterize how thioredoxin controls a signaling pathway shared among pathogenic bacteria, advance our understanding of Salmonella pathogenesis, and provide a foundation for developing future therapies against common bacterial pathogens.

PI_NAMEs: VAZQUEZ-TORRES, ANDRES  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Active Sites;Amino Acids;analog;Antibiotics;Antioxidants;Archaea;Area;Aspartate;Bacteremia;Bacteria;Binding;Biochemical;Biological Assay;biophysical techniques;Catalytic Domain;CD4 Positive T Lymphocytes;Cell Culture System;Client;Cues;Defect;Development;Diarrhea;Disease;Disulfides;Elements;Eukaryota;Evolution;Face;Foundations;Future;Gene Expression;Genes;genetic approach;genetic regulatory protein;Genetic Transcription;Histidine;HIV;Homeostasis;Human;Hydrophobicity;Immunocompromised Host;in silico;In Vitro;in vivo;Individual;Infection;insight;interfacial;Investigation;Knowledge;Leucine;Life;Macrophage;Mediating;Modeling;Mutation;neutrophil;next generation;non-typhoidal Salmonella;novel;Oxidation-Reduction;Oxidoreductase;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity Island;Persons;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Phylogenetic Analysis;Play;Post-Translational Regulation;preservation;programs;Prokaryotic Cells;protein protein interaction;Proteins;Publishing;Reaction;Recombinants;Regulation;Research;response;Role;Salmonella;Salmonella enterica;Salmonella infections;sensor;Signal Pathway;Signal Transduction;Source;Sulfhydryl Compounds;Surface;System;Testing;Thiol Disulfide Oxidoreductase;transcription factor;TXN gene;Type III Secretion System Pathway;Valine;Variant;Virulence;Work

PROJECT_TITLE: Analysis of regulatory networks in Salmonella pathogenesis.

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ED_INST_TYPE: SCHOOLS OF EDUCATION

ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE High-altitude mammals have evolved exquisite physiological adaptations to survive and function under conditions of chronic oxygen-deprivation (hypoxia) that mimic disease states in humans. For this reason, identifying and characterizing evolved mechanisms of hypoxia adaptation in high-altitude mammals may provide insights that guide the design of novel therapeutic interventions for patients suffering from various forms of metabolic or cardiorespiratory diseases. The goals of this research project are to elucidate the mechanistic basis of hypoxia resistance in high-altitude mice, and to identify changes in gene expression and genetic regulatory networks that are responsible for adaptive enhancements of physiological performance in hypoxia.

PI_NAMEs: STORZ, JAY  (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Acclimatization;Aerobic;Aerobic Exercise;Altitude;American;Andean;Animals;ATP Synthesis Pathway;Biological;Blood gas;Candidate Disease Gene;Cardiovascular system;Catheters;Chronic;Comparative Study;Complex;Consumption;Deer Mouse;deprivation;design;Disease;DNA Resequencing;Down-Regulation;Ear;Evolution;Exercise;exercise capacity;Experimental Designs;experimental study;Feedback;follow-up;functional genomics;Gene Expression;Gene Expression Profile;gene function;gene network;Genes;Genetic;Genetic Crosses;Genetic Polymorphism;Genetic Transcription;Genome Scan;Genomics;Genotype;Goals;Human;human subject;Hypoxia;Hypoxia Pathway;in vivo;insight;instrumentation;Mammals;Measures;Mediating;Metabolic;metabolomics;Mitochondria;Mus;Muscle;natives;novel;novel therapeutic intervention;Nucleotides;Operative Surgical Procedures;Organ;Outcome;Oxygen;Pathway interactions;Patients;Performance;Peromyscus;Phenotype;Physiological;Physiological Adaptation;Physiology;Plant Leaves;Population;programs;Research;Research Project Grants;Resistance;respiratory;response;Rodent;Sampling;Sea;South American;stem;Structure;System;Testing;Tissue-Specific Gene Expression;Tissues;trait;transcription factor;transcriptomics;Translating;Up-Regulation;Variant;Venous;VO2max;Work

PROJECT_TITLE: Genomic and physiological mechanisms of hypoxia adaptation in high-altitude mice

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_NAME: LOVELACE BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: NM

PHR: Narrative This innovative project will use objective neuroimaging and neuropsychological measures to examine the efficacy of music training to alleviate the effects of prenatal alcohol exposure in children with a fetal alcohol spectrum disorder (FASD). We hypothesize that music training will benefit children with an FASD by improving sensory and motor function in combination with improving brain connectivity more broadly, leading to improved cognitive and behavioral functioning. This study addresses the needs of children with an FASD, their families, and the NIAAA Strategic Plan which calls for new intervention approaches to improve the quality of life of individuals impacted by prenatal alcohol exposure.

PI_NAMEs: STEPHEN, JULIA MARIE (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: 16 year old;Academic skills;active control;Active Listening;Address;Adult;Age;age effect;age group;Attention;Auditory;auditory discrimination;Auditory Perception;Behavior;behavior measurement;Behavior Therapy;Behavioral;Blinded;Brain;Child;Code;Cognition;Cognitive;cognitive benefits;cognitive function;cognitive skill;cognitive training;Complex;Cross-Over Studies;Crossover Design;Diffusion Magnetic Resonance Imaging;Disease;Dose;Educational Intervention;efficacy evaluation;Electroencephalography;emotion regulation;Environment;Evidence based intervention;executive function;Exhibits;experience;Family;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;frontal lobe function;Future;High Prevalence;improved;improved outcome;inattention;indexing;Individual;innovation;instrument;Intervention;life span;Lifestyle-related condition;Magnetic Resonance Imaging;Magnetoencephalography;Measurable;Measures;Modeling;Motor;Motor Skills;multidisciplinary;multisensory;Music;National Institute on Alcohol Abuse and Alcoholism;neural;neuroimaging;Neuronal Plasticity;neurophysiology;Neuropsychology;Outcome;Outcome Assessment;Outcome Measure;Parents;Participant;Perception;Performance;Phase;Pilot Projects;Play;primary outcome;Procedures;Qualifying;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;reduce symptoms;Regulation;response;Role;Sampling;Schools;Sensory;sensory integration;Short-Term Memory;skills;sound;Strategic Planning;Structure;Structure of supramarginal gyrus;Testing;Time;Training;trial comparing;United States;United States National Institutes of Health;Visual Perception

PROJECT_TITLE: The synchrony study: A randomized controlled trial of music training for children with FASD

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Infectious Diseases;Precision Medicine

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Narrative Understanding how host cells and pathogens interact is key to developing new and individualized therapeutics. Here, we will develop novel computational tools and models to analyze existing and newly generated high throughput data and construct multi-dimensional host pathogen interaction maps. These maps will provide detailed mechanisms underpinning multi-faceted interactions occurring between host and pathogen and will delineate molecular subtypes that can be utilized for novel and personalized treatment options.

PI_NAMEs: KAZEMIAN, MAJID  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Affect;Cells;Cellular biology;ChIP-seq;Chronic;Clinical;Communicable Diseases;Computer Models;computerized tools;Data;data mining;Detection;Development;Dimensions;Disease;effective intervention;Exclusion;Gene Expression;Genes;Genetic Transcription;genome analysis;genome-wide;genomic data;Genomics;Human Herpesvirus 4;Immune checkpoint inhibitor;Immune Evasion;Immunity;Infection;Inflammation;insight;Investigation;lens;Link;Machine Learning;Malignant - descriptor;Maps;Methods;Modeling;Molecular;Molecular Classification of Tumors;molecular subtypes;mortality;Mutation;Nature;neoplastic cell;novel;novel therapeutics;Outcome;pathogen;Pathogenesis;personalized cancer therapy;personalized intervention;personalized medicine;personalized therapeutic;Positioning Attribute;programs;Regulation;Resistance;RNA-Binding Proteins;Sampling;success;System;tool;tool development;transcription factor;treatment strategy;tumor;Variant;Viral;Virus Integration

PROJECT_TITLE: Dissecting host-pathogen interactions through the lens of genomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Human Genome;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: The embryonic hindgut or cloaca progresses from a single hollow organ to two separate entities – the urinary tract and anorectal tract. The urinary tract further differentiates into the bladder rostrally and the genital urethra caudally. This proposal is to generate critical resources such as spatial transcriptome and epigenome from the same and single cell to achieve comprehensive understandings of urinary tract development.

PI_NAMEs: LI, XUE SEAN (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: 3-Dimensional;Anatomy;Area;Atlases;Bladder;bladder trigone;Case Study;Cell Nucleus;cell type;Cells;Cloaca Chamber;Collection;Communities;Complex;Congenital Abnormality;Data;Data Set;density;design;Development;Developmental Process;digital;Digital Libraries;Disease;Dorsal;Embryo;epigenome;epigenomics;Gene Expression Profile;Generations;Genes;Genitalia;Genitourinary system;Glass;Goals;Graph;Hindgut;Histology;Human;Image;improved;innovation;innovative technologies;Joints;Life;Location;Lower urinary tract;Maps;Mesenchyme;Molecular;molecular marker;Molecular Profiling;Multiomic Data;multiple omics;Mus;novel;Organ;Play;Reporting;Research;Resolution;Resources;response;Role;Series;Signaling Molecule;Slice;Slide;Spottings;Structure;Structure of umbilical artery;Technology;Tissue-Specific Gene Expression;Tissues;transcription factor;transcriptome;transcriptomics;Ureter;Urethra;Urinary tract;urogenital tract;Vascular System;virtual;virtual human;Visualization

PROJECT_TITLE: The single and same cell 3D atlas of epigenome and transcriptome of the lower urinary tract


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: AMES

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Project Narrative The Neglected Tropical Diseases include filariases, the parasitic nematode infections transmitted by biting insects. Examples include River Blindness caused by Oncherca volvulus, Lymphatic Filariasis produced by Brugia malayi and African eye worm caused by Loa loa. Control of these nematode parasites (adults or larvae) relies on a limited number of anthelmintic drugs. This proposal seeks to identify and compare the modes of action and interactions of emodepside and diethylcarbamazine on ion-channel targets of important species of filaria. The overall impact of this new knowledge of the mode of actions and interactions of emodepside and diethylcarbamazine will support evolutions of their use and the development of needed therapies for the control of filariases. .

PI_NAMEs: MARTIN, RICHARD JOHN (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Adult;Adult women;Adverse effects;African;Anthelmintics;Arachidonic Acids;Area;Basic Science;Blindness;Brugia;Brugia malayi;Calcium;Combined Modality Therapy;comparative;desensitization;design;detection sensitivity;Development;Diethylcarbamazine;differential expression;Disease;Disputes;Dopachrome isomerase;drug action;Drug Interactions;Evolution;Exposure to;Eye;Female;filaria;Filarial Elephantiases;Filariasis;gastrointestinal;Homologous Gene;Human;human model;In Situ;In Vitro;Infection;innovation;Insect Bites;Intestinal Volvulus;Ion Channel;knock-down;Knowledge;Larva;Life Cycle Stages;Loa;Loa loa;Loiasis;male;Mediating;Messenger RNA;Microfilaria;Molecular;mortality;Motility;Muscle;neglected tropical diseases;Nematoda;Nematode infections;novel therapeutics;Ocular Onchocerciasis;Onchocerca;Onchocerca volvulus;Onchocerciasis;Oocytes;Parasites;Parasitic nematode;patch clamp;Pathway interactions;Persons;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;phase II trial;Potassium Channel;Prevention;programs;Prophylactic treatment;Recovery;Research;Resistance;response;Risk;RNA Splicing;Services;sex;Site;success;Techniques;Testing;Toxic effect;transmission process;vaccine access;Variant

PROJECT_TITLE: Slo-1K channels, TRP-2 channels, emodepside and diethylcarbamazine in Filaria


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: BOSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Patients with tuberculosis (TB) can benefit greatly if we could identify signs of poor response earlier and adjust therapy intensity accordingly. Innovations in DNA isolation and sequencing technologies now enable the study of TB pathogen populations in an individual patient with very high resolution. Here, we propose to use these technologies and a highly well-characterized cohort of South African TB patients to investigate how pathogen population genetic changes link to pathogen survival and treatment response, laying the foundation for improvements in clinical treatment monitoring using DNA sequencing.

PI_NAMEs: FARHAT, MAHA  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Adherence;Adopted;Affect;Aftercare;Alcohol abuse;Alcohol consumption;Anabolism;Antibiotic Therapy;Antibiotics;arms race;Attenuated;Bacteria;Biohazardous Substance;Bioinformatics;Biological;Biological Response Modifiers;Clinical;clinical predictors;Clinical Treatment;Cobalamin;cohort;Communicable Diseases;Complex;Data;Data Set;Development;Diagnosis;DNA;DNA sequencing;Drug Kinetics;Drug resistance;Drug Tolerance;Early identification;Early Intervention;Evaluation;Evolution;experience;Failure;Family;Foundations;Gene Frequency;Genes;Genetic;Genetic Recombination;genetic variant;Genetic Variation;Genome;genome sequencing;Genomic approach;genomic variation;Genomics;Genotype;Geography;Growth;Heritability;high risk;HIV;Human;Immune;Immune response;Immune system;Immunocompetence;immunological status;Immunotherapeutic agent;improved;improved outcome;in silico;Individual;individual patient;Infection;innovation;Integration Host Factors;Intervention;Iron;Isoniazid resistance;Knowledge;Link;Machine Learning;Measurable;medication compliance;Metabolic;Methodology;Methods;Minimum Inhibitory Concentration measurement;Minor;Modeling;Molecular;Monitor;Mutation;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;novel;Outcome;pathogen;pathogen genomics;Pathway interactions;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Phenotype;Population;Population Genetics;Population Heterogeneity;Prediction of Response to Therapy;predictive modeling;Predisposition;pressure;prevent;prospective;real time monitoring;recruit;Recurrent disease;Regulator Genes;Relapse;relapse risk;Resistance;Resistance development;resistance gene;resistant strain;Resolution;response;Rifampin;Role;Sampling;Source;South Africa;South African;Specific qualifier value;Specimen;Speed;Sputum;statistical learning;Sterilization;Technology;Test Result;Testing;Time;Training;Treatment Failure;Treatment outcome;Treatment Protocols;treatment response;Tuberculosis;tuberculosis treatment;Variant;Virulent;whole genome;Work

PROJECT_TITLE: Investigating bacterial contributions to TB treatment response: a focus on in-host pathogen dynamics

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Accumulating evidence indicates that infections with a newly-discovered species of rhinovirus, RV-C, are associated with severe respiratory tract infections and asthma exacerbations often requiring hospitalization. This proposal will examine how RV-C initiates asthma attacks via expansion and activation of type 2 innate lymphoid cells. Insight into RV-C pathobiology will lead to therapeutic interventions against viral-induced airways disease.

PI_NAMEs: HERSHENSON, MARC B. (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: 4 year old;Adrenal Cortex Hormones;Air;Airway Disease;airway epithelium;airway hyperresponsiveness;airway inflammation;Alleles;Allergic;Animal Model;aspirate;Asthma;asthma exacerbation;asthmatic;Bronchiolitis;Cadherins;Cell surface;Cells;cellular transduction;Child;Clone Cells;cytokine;Cytoplasm;Data;Development;Dexamethasone;Diagnosis;Disease;eosinophil;eosinophilic inflammation;Epithelial Cells;Epithelium;experimental study;Family;Family member;Flow Cytometry;Gene Expression;Genotype;Hela Cells;high risk;Hospitalization;Human;human subject;IL2RA gene;IL7R gene;In Vitro;in vivo;Individual;Infant;Infection;Inflammasome;insight;Intercellular adhesion molecule 1;Interleukin-13;Life;Link;Liquid substance;Low-Density Lipoproteins;Lung;Lymphoid Cell;Macrophage;Measures;Metaplasia;Modeling;Mucins;Mucous body substance;Mus;Nasopharynx;neutralizing antibody;Nose;old mice;overexpression;Pathogenesis;Phenotype;Phosphotransferases;Physicians;Pilot Projects;Predisposition;Production;Prospective Studies;Pyroglyphidae;receptor;Refractory;Research Personnel;Resistance;Respiratory Tract Infections;response;Rhinovirus;Rhinovirus infection;Role;Sampling;Signal Pathway;Steroids;Testing;Therapeutic Intervention;TSLP gene;Universities;Variant;Viral;virtual;Virus;Virus Diseases;Wisconsin

PROJECT_TITLE: Models of rhinovirus-C respiratory infection and asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: Project Narrative The proposed Indiana University School of Medicine (IUSM) Cooperative Center for Excellence in Hematology (CCEH) brings together 25 investigators whose research activities are focused on various aspects of nonmalignant hematology. The central theme of our CCEH is the regulation of human and murine hematopoiesis at the level of hematopoietic stem (HSC) and progenitor (HPC) cells. To facilitate and advance the research work of these investigators, we propose the establishment of an Administrative core that will oversee the operation of three centralized Biomedical Research cores and an Enrichment core to promote and encourage young scientists to pursue a career in nonmalignant hematology research.

PI_NAMEs: KAPUR, REUBEN  (contact);POLLOK, KAREN ELIZABETH

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Advanced Development;Affect;Area;Basic Science;Biological Process;Biomedical Research;Bone Marrow Diseases;career;cell behavior;Cell Cycle Regulation;Cell Separation;Cell Transplantation;Cells;Clinic;Clinical;clinical efficacy;Clinical Investigator;Clinical Trials;Communities;Core Facility;cost;Country;Cytometry;Development;Disease;Elements;Ensure;Environment;environmental enrichment for laboratory animals;Epigenetic Process;experience;Exposure to;Fostering;functional status;Funding;Funding Mechanisms;gene therapy;genetic approach;Goals;Growth;Growth and Development function;Health Benefit;Hematology;Hematopoiesis;Hematopoietic;hematopoietic engraftment;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;Hereditary Disease;Homing;Human;Hypoxia;improved;In Vitro;in vivo;Incubators;Indiana;Informal Social Control;Infrastructure;innovation;insight;interdisciplinary approach;Investigation;Ionizing radiation;Laboratories;medical schools;member;migration;Mission;Modality;Molecular;Molecular and Cellular Biology;Mus;Non-Malignant;operation;Peer Review;Productivity;progenitor;programs;Proliferating;Publications;Publishing;Qualifying;Regulation;Research;Research Activity;Research Personnel;Resources;Scientist;Secure;self-renewal;Seminal;Services;Signal Transduction;skills;stem;stem cell biology;Stem cell transplant;success;Technology;Tissues;translational study;Translations;transplantation therapy;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Hematopoietic stem and progenitor cell regulation for enhanced clinical efficacy


NIH_SPENDING_CATS: Genetics

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Nuclear export of macromolecules is required to move them from the nucleus from the cytoplasm, but how the XPO1-dependent export is regulated is not fully understood. To address this gap in knowledge, we will investigate whether XPO1 alterations or inhibition perturbs RNA export and how that affects gene expression, splicing, and translation given the known role of XPO1 to export certain messenger RNA, small nuclear RNA, and ribosomal RNA species via RNA-binding proteins.

PI_NAMEs: TAYLOR, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Affect;Apoptosis;Binding;Binding Proteins;Biochemical;Biology;Cell Line;Cell Nucleus;Cells;Cytoplasm;Data;Disease;Eukaryotic Cell;exportin 1 protein;Exposure to;Future;Gene Expression;Genetic Engineering;genetically modified cells;Genomics;Goals;Grant;inhibitor;Knock-in Mouse;Knowledge;Laboratories;macromolecule;Mediating;Medical;Messenger RNA;Mission;Mitotic Cell Cycle;Modeling;Molecular;Molecular Biology;mouse model;mRNA Translation;mutant;Mutation;National Institute of General Medical Sciences;Nuclear;Nuclear Export;nuclear factors of activated T-cells;overexpression;Pathogenesis;Pharmaceutical Preparations;Process;Protein Export Pathway;Proteins;Proteomics;Regulation;Research;Ribosomes;RNA;RNA Splicing;Role;Science;Signal Transduction;therapy design;Translations;Work

PROJECT_TITLE: The role of XPO1 in nuclear export of RNA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


NIH_SPENDING_CATS: Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human;Transplantation

PHR: Narrative N/A

PI_NAMEs: BROXMEYER, HAL E. (contact)

PROJECT_TERMS: Adopted;Adult;Area;Basic Science;Biochemical;Biology;Biomedical Research;Blood Vessels;Bone Marrow Diseases;Cell Cycle Regulation;Cells;chemokine;Childhood;Clinic;Clinical;clinical efficacy;Clinical Research;Collaborations;Country;cytokine;Developmental Biology;Discipline;Disease;Elements;Ensure;Epigenetic Process;Expenditure;experience;Fostering;Funding;Funding Mechanisms;Future;Gene Transfer;genetic approach;Goals;Growth Factor;Health Benefit;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;hematopoietic tissue;Hereditary Disease;Homing;Human;Immunology;improved;Indiana;innovative technologies;insight;interest;Investigation;Medical Genetics;medical schools;Medicine;member;Microbiology;migration;Modality;Molecular;Molecular Biology;Molecular Genetics;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Malignant;Orthopedic Surgery;Pediatrics;Policies;progenitor;programs;Proliferating;Qualifying;Regulation;Research;Research Personnel;Scientist;self-renewal;Services;Source;stem;stem cell biology;stem cell therapy;Stem cell transplant;Technology;Training Programs;translational potential;Transplantation;Travel;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: Watertown

ORG_NAME: ALDATU BIOSCIENCES, INC.

PHR: Ebolavirus [EBOV] and Marburgvirus [MARV] are filoviruses that cause severe hemorrhagic fevers in humans and primates. Clinical diagnosis of EBOV and MARV is difficult as the early stages (i.e., pre-hemorrhagic) present with non-specific symptoms associated with a range of febrile illnesses that are also displayed by other infectious agents endemic to affected areas e.g., malaria, yellow fever, dengue fever, influenza, Crimean-Congo hemorrhagic or Lassa fevers. In order to isolate infected individuals, effective control during an EBOV or MARV outbreak can only be achieved by implementing rapid and accurate diagnostics with consistently reliable performance. We propose to leverage the unique capabilities of PANDAA, our qPCR-enabling technology that mitigates the effects of genetic variability on test performance, to develop a rapid, sensitive molecular diagnostic assay for the detection and differentiation of EBOV and MARV with superior performance compared to existing diagnostics and won’t be affected by genetic changes in new viral variants. PANDAA will provide a rapid, standardized testing option for all endemic regions and can be deployed using pre-existing qPCR equipment in central labs to radically improve the diagnostic workflow.

PI_NAMEs: MACLEOD, IAIN JAMES (contact)

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: accurate diagnostics;Affect;Area;associated symptom;Binding Sites;Biological Assay;Biological Sciences;Buffers;Certification;clinical diagnosis;Collaborations;Consensus;Country;Crimean Hemorrhagic Fever;Custom;Dengue Fever;design;Detection;detection assay;detection limit;Development;Diagnostic;Diagnostic Reagent Kits;Disease Outbreaks;Drug resistance;Dryness;Ebola virus;Ensure;epidemic preparedness;epidemic response;Equipment;Evaluation;evaluation/testing;Fever;Filovirus;Fluorescent Probes;Genetic;Genetic Polymorphism;Genome;Genomic Segment;Genomics;Geography;Goals;Hemorrhage;HIV;Human;improved;in silico;Individual;Infectious Agent;Influenza;innovation;Institution;Lassa Fever;Lassa virus;low and middle-income countries;Malaria;manufacture;Marburgvirus;Methods;Molecular;Molecular Diagnostic Testing;molecular diagnostics;multiplex assay;Mutation;novel;outbreak concern;Pan Genus;pathogen;Pathogen detection;Performance;performance tests;Positioning Attribute;Primates;priority pathogen;Process;Production;prototype;Quality Control;Rapid diagnostics;Reaction;Reagent;Reproducibility;research and development;resistance mutation;RNA;Sampling;Serum;Site;Specificity;Standardization;System;Techniques;Technology;Testing;thermostability;Validation;Variant;Viral;Viral Hemorrhagic Fevers;Work;Yellow Fever

PROJECT_TITLE: PANDAA for universal, pan-lineage molecular detection of filoviruses to enable rapid epidemic response.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(13)]


NIH_SPENDING_CATS: Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human;Transplantation

PI_NAMEs: POLLOK, KAREN ELIZABETH (contact)

PROJECT_TERMS: Acclimatization;Adult;Air;AMD3100;Animals;Biology;Bone Marrow;Bone Marrow Transplantation;boys;Breeding;career;Cell Culture Techniques;Cell Physiology;cell type;Cells;Chimerism;Clinical;clinical efficacy;Collecting Cell;Communities;congenic;Congenic Mice;Consultations;cost;CSF3 gene;Cytometry;Data Analyses;Dedications;design;Dose;education resources;Ensure;Experimental Designs;experimental study;Faculty;Funding;Future;Goals;graduate student;Granulocyte-Macrophage Colony-Stimulating Factor;Growth Factor;Harvest;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Human;Human Resources;Hypoxia;IL3 Gene;Immune;Immunodeficient Mouse;in vivo;Individual;Infrastructure;Investigation;irradiation;Laboratories;Medical Students;member;Methodology;Molecular;Mouse Strains;Mus;next generation;Non-Malignant;peripheral blood;prevent;Procedures;Process;Production;Regulation;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Sampling;Scientist;Services;Site;stem cell biology;stem cell function;Technical Expertise;Therapeutic;Time;Tissue Transplantation;Tissues;Training;Training Activity;Transgenic Organisms;transplant model;Transplantation;Umbilical Cord Blood;Work

PROJECT_TITLE: Experimental Mouse Resources Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Liver Disease

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative While CAR T cells therapy are very promising, the precise targeting to cancer cells with minimal off-tumor tox- icity remains a significant challenge. Thus, we will use our novel SUPRA CAR system in human T cells and a liver transgene expression mouse model to interrogate human therapeutics while addressing in vivo off-tumor toxicity in animals. Successful completion of the project aims will afford material and designs for improved CAR T cell treatments for a wide array of cancers, including solid tumors.

PI_NAMEs: COLSON, YOLONDA L;GRINSTAFF, MARK W.;WONG, WILSON  (contact)

PROGRAM_OFFICER_NAME: YOVANDICH, JASON L

PROJECT_TERMS: Adaptor Signaling Protein;Address;Affect;Animals;Antigen Targeting;Antigens;Binding;Biocompatible Materials;Bioinformatics;Blood;cancer cell;CAR T cell therapy;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical implementation;Collaborations;Data;design;Devices;Dimensions;efficacy evaluation;Engineering;Experimental Designs;experimental study;extracellular;Fiber;Future;Hepatotoxicity;Human;immunoengineering;Immunology;Implant;improved;in vivo;in vivo evaluation;Infection;Leucine Zippers;Liver;Location;Logic;Malignant Neoplasms;Modeling;Monitor;mouse model;Mus;nano;Nature;neoplastic cell;novel;Outcome;ovarian neoplasm;prevent;Publishing;receptor;Receptor Signaling;Relaxation;ROR1 gene;Signal Pathway;Signal Transduction;Site;Solid Neoplasm;Specificity;success;synthetic biology;System;T-Cell Activation;T-Cell Receptor Therapy;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy development;Tissues;tool;Toxic effect;transgene expression;tumor;Tumor Biology;Tumor Burden;tumor specificity;Work

PROJECT_TITLE: Precise tumor targeting with logic CAR circuits


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: CITY OF INDUSTRY

ORG_NAME: PUBLIC HEALTH FOUNDATION ENTERPRISES

PHR: Project Narrative Antimicrobial drugs are widely used in human and veterinary medicine and resistance to existing therapies poses a significant threat to public health. This program supports surveillance for antimicrobial resistance among enteric bacteria in raw retail meat commodities which will serve to improve detection of emerging resistance to medically relevant antibiotics, inform parameters for antimicrobial use in veterinary medicine, and support foodborne illness outbreak investigations.

PI_NAMEs: TRAMMELL, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: YOUNG, SHENIA

PROJECT_TITLE: National Antimicrobial Resistance Monitoring System (NARMS) retail food surveillance in selected urban areas of northern California.


NIH_SPENDING_CATS: Biomedical Imaging;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human

PI_NAMEs: SROUR, EDWARD F (contact)

PROJECT_TERMS: 3-Dimensional;Address;Animals;Basic Science;Biological;Biology;Cancer Center;Cell Communication;Cell Cycle;Cell Separation;Cells;clinical efficacy;Clinical Research;Collection;Color;Common Core;Complement;cost effective;Country;Cytometry;Data;Data Analyses;design;digital imaging;Equipment;Flow Cytometry;Fluorescence;Funding;Goals;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Image;Image Analysis;imaging system;Immunophenotyping;Indiana;innovation;Institution;instrument;interest;intravital microscopy;Investigation;Kidney;Knowledge;Label;Lasers;live cell imaging;medical schools;member;Metabolic;Microscope;Microscopy;multiphoton microscopy;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Malignant;Operative Surgical Procedures;Output;Preparation;Productivity;progenitor;Proteomics;Protocols documentation;Publications;quantitative imaging;Regulation;Research;Research Activity;Research Design;Research Personnel;Research Support;Resources;Services;Spatial Distribution;spatial relationship;Standardization;stem;stem cell biology;Stem Cell Research;Stream;Stress;Technology;Tissue imaging;Tissues;tool;Universities

PROJECT_TITLE: Flow and Tissue Cytometry Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Eye movements incessantly occur in healthy humans and directly affect the spatiotemporal patterns of light in- cident on the retina. By investigating the functions of eye movements, this project will advance understanding of normal human vision as an integrated sensorimotor process and may lay the groundwork for new treatment approaches for visual impairments, including, but not limited to, those associated with abnormal eye movements.

PI_NAMEs: RUCCI, MICHELE  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: 3-Dimensional;Address;Advocate;Affect;Area;Automobile Driving;Behavior;Binocular Vision;Cephalometry;Characteristics;Code;Contrast Sensitivity;Data;Depth Perception;Development;Disease;Disparity;experimental study;Eye;Eye Abnormalities;Eye Movements;flexibility;Foundations;Frequencies;Funding;gaze;Goals;Head;Human;Image;Image Enhancement;Impairment;information processing;instrumentation;Investigation;Knowledge;Learning;Light;Location;luminance;Mainstreaming;Maps;Measurement;Modeling;monocular;Motion;Motor;Movement;multimodality;Nature;neglect;neural;Neurons;novel;novel therapeutic intervention;oculomotor;Optics;Outcome;Pattern;Perception;Play;Process;Prosthesis;receptor;Rehabilitation therapy;Reporting;Research;Resolution;Retina;retinal imaging;retinal stimulation;Role;Saccades;sample fixation;Shapes;Signal Transduction;spatiotemporal;Stimulus;Stream;Testing;theories;Time;United States National Institutes of Health;Vision;Vision Disparity;vision science;Visual;Visual Acuity;Visual impairment;visual motor;Visual System;visual tracking;Work

PROJECT_TITLE: Function of Fixational Instability During Natural Viewing


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Hematology

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Our Coordinating Center will meet the need of the NIDDK Cooperative Centers of Excellence in Hematology (CCEH) by creating and overseeing the 1) administrative infrastructure to organize interactions and facilitate collaborations between CCEH investigators, 2) oversight of programs using set-aside funds to stimulate collaborative research through a competitive Pilot and Feasibility Program, 3) timely sharing of CCEH- generated data and reagents among CCEH investigators from all centers and within the broader research community exploring areas of non-malignant hematology, and 4) we will make these advances, opportunities and programs known to the scientific community and to the public at large through a cross center website.

PI_NAMEs: BEAUDIN, ANNA E  (contact);STIREWALT, DEREK L

PROJECT_TERMS: Acceleration;Advisory Committees;Applications Grants;Area;Award;base;Cell Line;Collaborations;combat;Communication;Communication Methods;Communication Tools;Communities;Complex;Continuing Education;Data;Data Analyses;data platform;data sharing;Education;Education and Outreach;Educational Materials;Educational workshop;Electronic Mail;Ensure;Evaluation;experience;Facebook;Funding;Funding Opportunities;Goals;Grant;Hematological Disease;Hematology;Hematopoiesis;improved;Individual;Information Distribution;Infrastructure;innovation;Instagram;interest;International;Laboratories;Leadership;Logistics;meetings;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Newsletter;Non-Malignant;novel strategies;outreach;outreach program;Pamphlets;posters;Process;programs;Progress Reports;Protocols documentation;Reagent;recruit;Reproducibility;Research;Research Personnel;Research Proposals;Resources;Science;Senior Scientist;Site;skills training;Slide;social media;Standardization;success;symposium;Technology;Telephone;Time;tool;Twitter;Universities;Utah;ward;web site;webinar

PROJECT_TITLE: Hematology Central Coordinating Center (HCCC) for the NIDDK Hematology Centers Program


NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human

PROJECT_TERMS: Adult;Air;Applications Grants;Area;Biochemical;Birth;Blood Cells;Bone Marrow;Cell Death;Cell Differentiation Induction;Cells;Cellular biology;Clinical;clinical efficacy;clinical translation;Collecting Cell;Collection;Communities;Core Grant;cost;cyclophilin D;cytokine;Data;Economics;Environment;Evaluation;Event;Exposure to;Gene Expression Profile;General Population;Health Benefit;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human;Hypoxia;Immune;improved;In Vitro;in vivo;Indiana;insight;Journals;knockout gene;Knockout Mice;Learning;Life;Maintenance;Mediator;Medicine;member;Mitochondria;mitochondrial permeability transition pore;Molecular;mouse model;Mus;Nobel Prize;Non-Malignant;Organ;Oxygen;peripheral blood;Phenotype;Physiological;Physiology;Preleukemia;Process;Production;Productivity;progenitor;programs;Publications;Publishing;Qualifying;Regulation;Reporting;Research;Research Personnel;Resources;Role;Scientist;Services;Shock;stem;stem cell biology;stem cell function;Stimulus;Stress;Stromal Cells;TP53 gene;translational potential;Umbilical Cord Blood;Universities;Work

PROJECT_TITLE: Hypoxia Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Nanotechnology;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Our project is designed to develop a quantitative imaging (QI) tool for monitoring tumor response to cancer immunotherapies that activate tumor associated macrophages (TAM). We will optimize and validate pre- clinical QI methods for TAM imaging in established mouse models, implement the optimized methods in a co- clinical trial and populate a web-accessible research resource with all the data, methods, and results collected from these investigations. Our TAM imaging resource will allow other investigators to evaluate their own images with standardized protocols, participate in centralized analyses of pooled data and generate novel hypotheses for cancer immunotherapy response assessments.

PI_NAMEs: DALDRUP-LINK, HEIKE ELIZABETH (contact);GATIDIS, SERGIOS

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: Aftercare;Animal Model;anticancer activity;Biological Markers;Blocking Antibodies;cancer cell;cancer clinical trial;cancer imaging;cancer immunotherapy;cancer therapy;CD47 gene;Cell Physiology;Cell surface;Cells;chemotherapy;Clinic;Clinical;clinical application;clinical imaging;clinical investigation;Clinical Research;clinical translation;Clinical Trials;Clinical Trials Design;co-clinical trial;Communities;comparative efficacy;Computer software;Consensus;Darkness;Data;Data Pooling;design;Development;Diagnosis;Disease;Eating;efficacy study;Elements;FDA approved;ferumoxytol;first-in-human;Goals;Growth;Healthcare;Histology;Hour;Image;imaging approach;imaging biomarker;Imaging Device;imaging modality;imaging study;Imaging Techniques;immunomodulatory therapies;Immunotherapy;improved;improved outcome;in vivo;Industry;Injections;Institution;Integral Membrane Protein;interest;Intravenous;intravenous injection;Investigation;iron oxide nanoparticle;iron supplement;Learning;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;Methods;Monitor;Monoclonal Antibodies;Monoclonal Antibody Therapy;mouse model;Multi-Institutional Clinical Trial;nanoparticle;Necrosis;Neoplasm Metastasis;neoplastic cell;next generation;novel;novel therapeutics;off-label use;Operative Surgical Procedures;Osteosarcoma;Outcome Measure;patient population;Patient-Focused Outcomes;Patients;pediatric patients;Phagocytes;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Positioning Attribute;pre-clinical;preclinical imaging;preclinical study;predicting response;Prediction of Response to Therapy;Protocols documentation;quantitative imaging;receptor;Reference Standards;Reproducibility;Research;Research Personnel;Resources;response;Sarcoma;SHPS-1 protein;Signal Transduction;Speed;Standardization;Testing;Therapeutic;Time;Translating;treatment response;treatment stratification;tumor;tumor eradication;tumor growth;tumor progression;Tumor-associated macrophages;uptake;web-accessible;Work

PROJECT_TITLE: Co-Clinical Research Resource for Imaging Tumor Associated Macrophages


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The Columbia University Training Program in Lung Science aims to utilize the rich faculty and didactic resources at the University to train postdoctoral scientists pursuing either basic science or translational research in lung disease, to prepare them for scientific careers in academia.

PI_NAMEs: BHATTACHARYA, JAHAR  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Clinical Research;HIV/AIDS;Lung;Social Determinants of Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Most global COPD morality occurs in regions of the world where smoking is uncommon such as sub-Saharan Africa – home to an estimated 26 million people with COPD – where the converging HIV and air pollution epidemics may be driving COPD mortality. This project characterizes personal air pollution exposure among 300 people with HIV and 300 HIV-uninfected comparators in Uganda and uses spirometry and research bronchoscopy to examine whether HIV serostatus influences relationships between air pollution, inflammation and lung function. Findings from this study will inform future interventions designed to improve lung health among these at-risk populations by targeting the candidate mechanistic pathways identified in this proposal.

PI_NAMEs: NORTH, CRYSTAL  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Africa South of the Sahara;African;Age;Air;Air Pollution;Area;Automobile Driving;Award;Biometry;Bronchoalveolar Lavage;Bronchoscopy;career;Career Choice;Cause of Death;CD4 Lymphocyte Count;Chronic;Chronic Disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Investigator;cohort;Collaborations;Complex;cytokine;Data;Deterioration;disorder risk;Enrollment;Ensure;Environmental Exposure;Epidemic;Epidemiologic Methods;Epidemiology;Equation;experience;Exposure to;Face;fine particles;Functional disorder;Funding;Future;General Hospitals;Goals;high risk;HIV;HIV Infections;Home;Hour;Immune;immune activation;Immunology;improved;Inflammation;Inflammatory;innovation;insight;Institution;Investigation;Longitudinal cohort;Lung;Lung Diseases;lung health;lung injury;Malnutrition;Manuscripts;Massachusetts;Measurement;Measures;Mediating;Mentors;Mentorship;Methodology;Modeling;Monitor;Morality;mortality;multiplex assay;National Heart, Lung, and Blood Institute;non-smoker;non-smoking;novel;Participant;Pathway interactions;Patient Care;Persons;Pilot Projects;Population;Populations at Risk;Positioning Attribute;Predisposition;Prevalence;Procedures;Public Health Schools;Publications;Publishing;pulmonary function;Pulmonary Inflammation;Recording of previous events;Research;Research Infrastructure;Research Personnel;Research Priority;Research Training;Risk;Rural;Science;sex;Smoke;Smoking;Specimen;Spirometry;Structure of parenchyma of lung;success;systemic inflammatory response;Target Populations;Technology;Testing;therapy design;Training;Tuberculosis;Uganda;United States National Institutes of Health;Universities;Visit;Work

PROJECT_TITLE: The influence of air pollution on lung health among people living with HIV.

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human

PROJECT_TERMS: Animals;Award;Biomedical Research;Breeding;career;clinical development;clinical efficacy;Clinical Trials;Collaborations;computerized;Disease;Education;Educational Status;Educational workshop;Environment;Faculty;Fostering;Future;Goals;Hematology;Hematopoietic stem cells;Hematopoietic System;improved;Indiana;Inherited;innovation;instrumentation;interest;Internships;Learning;member;Mentors;Molecular;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;next generation;Non-Malignant;Outcome;Phase;Productivity;programs;recruit;Regulation;Research;Research Personnel;Research Training;Resources;Scientific Advances and Accomplishments;Scientist;Series;student mentoring;Students;success;symposium;Talents;Technology;technology platform;Time;tool;Training;Training and Education;training opportunity;Travel;Universities;Work

PROJECT_TITLE: Enrichment Program


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Although tuberculosis (TB) – the leading cause of death among people living with HIV (PLHIV) – can be prevented with only 12 weekly doses of isoniazid and rifapentine (3HP), implementation studies in sub-Saharan Africa have shown low rates of completion. The proposed studies will explore how two low-cost digital adherence technologies (DAT) can be adapted to address barriers to 3HP completion and conduct pilot studies to evaluate their acceptability, feasibility and preliminary effectiveness. The results will inform a future trial comparing the effectiveness and cost-effectiveness of contextually adapted DATs vs. routine care to support scale-up of 3HP or other novel, short-course regimens for TB prevention among PLHIV.

PI_NAMEs: BERGER, CHRISTOPHER ALLEN (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: active method;Address;Adherence;Adoption;Africa South of the Sahara;Agreement;Behavior;career;Cause of Death;Cessation of life;Clinic;compare effectiveness;Consolidated Framework for Implementation Research;cost;cost effectiveness;Coupled;Data;Data Analyses;Data Collection;Dedications;design;Diagnosis;digital;Directly Observed Therapy;Dose;Educational workshop;Effectiveness;effectiveness evaluation;effectiveness outcome;Enrollment;Evaluation;Evidence based intervention;feasibility trial;Feedback;follow-up;Funding;Future;Goals;high risk population;HIV;HIV/AIDS;human centered design;implementation design;implementation evaluation;implementation fidelity;implementation intervention;implementation outcomes;implementation science;implementation strategy;implementation study;implementation/effectiveness;improved;Incidence;Intervention;Interview;isoniazid;Low income;Maps;Mentors;Mentorship;Methodology;Methods;Modeling;Monitor;mortality;mortality risk;Motivation;novel;Outcome;Parents;Participant;Patients;Persons;Physicians;Pilot Projects;pilot trial;prevent;Prevention;Preventive therapy;Provider;randomized trial;Recommendation;Regimen;Research;Research Infrastructure;Research Methodology;Research Personnel;rifapentine;routine care;Sampling;scale up;Scientist;screening;Self Administration;service delivery;skills;success;Surveys;Technology;technology platform;Testing;theories;Training;treatment arm;trial comparing;Tuberculosis;Uganda;United States National Institutes of Health;uptake;usability;Work;World Health Organization

PROJECT_TITLE: Digital adherence technologies to facilitate completion of short-course tuberculosis preventive therapy among people living with HIV


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Prevention

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative The proposed study focuses on understanding the mechanism/s mediating COVID Associated Pulmonary Aspergillosis (CAPA). Based on strong preliminary evidence and utilizing unique access to well-curated patient samples as well as innovative in vitro, ex vivo, and in vivo model systems we explore the novel hypotheses that lytic programmed cell death in pulmonary epithelial cells and red blood cell hemolysis increase the availability of nutrients including iron/heme, which drive siderophore-dependent acceleration in mold growth. Concurrently, SARS-2 and the antiviral cytokine milieu mitigate PMN recruitment and antifungal effector activation resulting in spore germination into large invasive hyphae that overwhelm antifungal immunity enabling 2° mold infection in an otherwise immunocompetent host. We believe that the results of the proposed study will shed new light on the fundamental biology mediating CAPA and may enable the development of improved therapeutic regimens that mitigate the risk of acquiring and succumbing to this devastating infection.

PI_NAMEs: LEAL, SIXTO MANUEL (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: 2019-nCoV;Acceleration;Affect;Air;Allergic Bronchopulmonary Aspergillosis;Anabolism;anti-fungal agents;Apoptosis;Aspergillus;Aspergillus fumigatus;Bacterial Pneumonia;Biological;Biological Availability;Biological Models;Biology;Bronchioles;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Cell Culture Techniques;Cell Line;Cells;chemokine;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;conditional knockout;COVID-19;COVID-19 prevention;COVID-19 treatment;Critical Pathways;cytokine;Cytolysis;Death Rate;Development;Divalent Cations;Epithelial Cells;Epithelium;Erythrocytes;Evaluation;Exhibits;Exposure to;FDA approved;Flow Cytometry;Functional disorder;fungus;Gene Expression;Germination;Growth;Heme;Hemolysis;Human;Hyphae;Immune;Immune response;Immune system;Immunity;Immunocompetent;Immunofluorescence Immunologic;Impairment;improved;In Situ;In Vitro;in vivo Model;Individual;Infection;Infection Control;Influenza;Inhalation Therapy;inhibitor;innovation;Intensive Care Units;Interferons;Iron;Iron Chelation;Knock-out;Knockout Mice;Laboratories;Liquid substance;Lung;Lytic;Macrophage;Mediating;Meta-Analysis;metal chelator;Metals;Microbe;microbial;migration;Modeling;Molds;Molecular;mouse model;Mus;mutant;Mycoses;neutrophil;novel;Nutrient availability;Outcome;pathogenic virus;Pathway interactions;Patients;pharmacologic;pre-clinical;Predisposition;prevent;Production;Proteins;Publications;Publishing;Pulmonary Pathology;recruit;Regimen;Reporter;Reproduction spores;risk mitigation;Role;Sampling;SARS-CoV-2 antiviral;SARS-CoV-2 infection;SARS-CoV-2 variant;severe COVID-19;Siderophores;Signal Transduction;single cell sequencing;small molecule inhibitor;Stimulus;Structure of parenchyma of lung;Surface;Syndrome;Testing;Therapeutic;Therapeutic Intervention;Toxic effect;transcriptomics;uptake;Viral;Virus Diseases

PROJECT_TITLE: The Impact of SARS-CoV-2 Immune Dysregulation on Antifungal Immunity

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Biofilms pose a major public health challenge as they often cause difficult to treat infections that exhibit properties such as antimicrobial resistance and persistence even with long courses of antibiotics. Investigating new signaling pathways that expand our understanding of biofilm formation, homeostasis, and persistence will provide new insight into improved treatment strategies.

PI_NAMEs: LANDER, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Acetylcholine;Antibiotics;Antimicrobial Resistance;Bacillus subtilis;Bacteria;Bacterial Genes;Behavior;Biological Models;Cell Communication;cell growth;Cell membrane;Cell Separation;Cells;Choline O-Acetyltransferase;Chromosome Mapping;Communities;Complex;Critical Pathways;Data;Detection;Development;Disease;Exhibits;Extracellular Matrix;fitness;gene discovery;Gene Expression;Gene Expression Regulation;gene synthesis;Genes;Genetic;Genomics;Goals;Gram-Positive Bacteria;Growth;gut-brain axis;Homeostasis;Homologous Gene;Human;improved;in vivo;Infection;insight;Ions;Knowledge;Laboratories;Libraries;Location;Membrane Potentials;Metabolic;Metabolic Pathway;Metabolism;Microbe;Microbial Biofilms;Microbiology;Microfluidics;Microscopy;model organism;Morphology;mutant;Nutrient;Organism;Outcome;Pathway interactions;Phenotype;Physiological;Production;Property;Public Health;quorum sensing;Research;screening;sensor;Signal Pathway;Signal Transduction;Signaling Molecule;Sorting;success;System;Time;treatment strategy

PROJECT_TITLE: Elucidating mechanisms of acetylcholine signaling in bacterial biofilms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-A(20)]


ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE It is an emerging principle that dynamic properties of molecules within a signaling network, such as sub-cellular changes in protein localization or abundance, provide a temporal codes that mediate cellular responses to stimuli. How dynamic molecular signals relay, and process, information is a critical gap in our understanding of how healthy and diseased cells make decisions. Here we propose a hybrid experimental and computational framework to decipher dynamic signals induced by inflammatory factors in single cells, and understand how cells interpret these signals to decide between inflammation, proliferation, or cell death.

PI_NAMEs: LEE, ROBIN E. C. (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Biological;cancer cell;Cell Culture Techniques;Cell Death;Cell Fate Control;Cell Line;Cell membrane;Cell Nucleus;Cells;Cellular Structures;Coculture Techniques;Code;Computational Technique;computer framework;Cytoplasm;Data;Data Set;Decision Making;Disease;experimental study;Frequencies;Genetic Transcription;Goals;Heterogeneity;high dimensionality;Hybrids;Immune;in vivo;Inflammation;Inflammatory;information processing;Knowledge;Learning;Ligand Binding;Link;live cell microscopy;Measurement;Mediating;Modeling;molecular dynamics;Pathway interactions;Process;Proliferating;Property;protein complex;Protein translocation;Proteins;quantitative imaging;rate of change;rational design;Reporter;response;Robot;Signal Induction;Signal Pathway;Signal Transduction;Stimulus;Structure;System;Testing;therapy design;Time;Tumor Necrosis Factor Receptor

PROJECT_TITLE: Deciphering dynamic signals in control of cell fate decisions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Aging;Genetics;Human Genome;Infectious Diseases;Interstitial Cystitis;Regenerative Medicine;Transplantation;Urologic Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Narrative Benign urologic diseases of the lower urinary tract cost over $5 billion dollars of health care expenditures each year in the US. The lack of novel therapies for these conditions is a direct result of a poor understanding of the molecular and cellular characteristics of these tissues in normal and disease states. The overall goal is to construct a highly integrated cellular and molecular anatomical map of the ureter and bladder in humans to enable comprehensively understanding.

PI_NAMEs: LEE, BYRON H;TING, ANGELA H;WESSELY, OLIVER  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Adolescent;Adult;Affect;Age;age group;Agreement;Algorithmic Analysis;analysis pipeline;Anatomy;Area;Atlases;Bacteria;Benign;Benign Prostatic Hypertrophy;Biological Assay;Bladder;Bladder Tissue;Cell Count;Cell Survival;cell type;Cells;Characteristics;Childhood;Chromatin;Collaborations;Communities;Consent;cost;Data;data hub;Data Set;Development;Disadvantaged;Disease;Elderly;experience;Family;Functional disorder;Gender;Gene Expression;Gene Expression Profile;gene regulatory network;Generations;Genes;Genitourinary system;Goals;Health Expenditures;healthcare burden;Histologic;Hospitals;Human;human old age (65+);human tissue;Immunofluorescence Immunologic;Individual;insight;Institutional Review Boards;Interstitial Cystitis;Life;life span;Location;Lower urinary tract;Maps;Messenger RNA;microbiome;Molecular;Nonprofit Organizations;Normal tissue morphology;Notification;novel;novel marker;novel therapeutics;Ohio;Operative Surgical Procedures;Organ;Organ Donor;Organ Procurements;organ regeneration;organ repair;Pathologic;Pathway interactions;Patients;pharmacologic;Physiological;prevent;Procedures;Process;Protein Isoforms;reconstruction;Recovery;recruit;repaired;Research;Resolution;Resources;response;sex;single cell genomics;single-cell RNA sequencing;Site;Specific qualifier value;Structure;System;Technology;Time;tissue processing;Tissue Procurements;Tissues;transcription factor;transcriptome;transcriptomics;Transplantation;Transposase;Ureter;Urethra;Urethral Stricture;urinary bladder neck;Urinary Incontinence;Urinary tract infection;Urologic Diseases;Viral

PROJECT_TITLE: High resolution transcriptome and gene regulatory mapping of human ureter and bladder across the lifespan


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Women's Health Research

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: PROJECT NARRATIVE The proposed research will develop and test the feasibility of a social-media based entertainment education intervention to prevent early childhood obesity in Hispanic infants, addressing two critical gaps in the literature: obesity prevention for children under 5 years and minority health. The intervention, Caring for Bebé, will be iteratively developed and tested with input from Hispanic mothers and grandmothers. Study results generated here will produce data and findings on three generations of Hispanic families (grandmother, mother, infant) participating in an early life obesity prevention intervention, inform the development and delivery of pregnancy and early life obesity prevention interventions, and advise actionable recommendations for pediatric and family clinical care delivered to diverse families.

PI_NAMEs: LEBRON, CYNTHIA NICOLE (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: 5 year old;acceptability and feasibility;Acculturation;Address;Adult;Affect;Age;Asian population;Attitude;Award;Behavior;behavior test;Behavioral;bilingualism;Birth;Black Populations;Black race;Breast Feeding;Cardiovascular Diseases;Caring;Child;Childhood;Chronic Disease;Clinic;clinical care;Clinical Research;Clip;Communication;comorbidity;Data;Daughter;design;Development;Diabetes Mellitus;Discipline of obstetrics;Disease;early childhood;Education;Educational Intervention;efficacy trial;ethnic disparity;Family;Family member;Feasibility Studies;feasibility testing;feasibility trial;Feedback;feeding;Female;Focus Groups;Food;Funding;Generations;Goals;Growth;Health;Health behavior;Health Care Costs;health data;Health Promotion;Heart Diseases;Hematological Disease;High Prevalence;high risk;Hispanic;Hispanic Populations;Hispanic Women;implementation research;improved;Individual;infancy;Infant;infant adiposity;Infant Care;Internet;Intervention;Intervention Trial;Knowledge;Latino Population;Length;Life;life span;Link;Literature;Lung Diseases;Maternal and Child Health;Measures;Mediator;Medical;Methods;Minority;minority health;Mission;Modality;Modeling;Mothers;National Heart, Lung, and Blood Institute;Needs Assessment;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel diagnostics;novel therapeutic intervention;Nursery Schools;Obesity;obesity in children;obesity prevention;obesity risk;Outcome;Overweight;Parents;pilot test;Pregnancy;pregnant;Pregnant Women;prenatal;Prevalence;prevent;preventive intervention;Primary Care;Process;programs;protective factors;prototype;Public Health;racial disparity;Randomized;Recommendation;Recording of previous events;recruit;Reporting;Research;research and development;Risk;Risk Factors;Sampling;School-Age Population;Science;secondary outcome;Self Efficacy;Sleep;Sleep Disorders;sleep quality;social cognitive theory;social media;Social Network;Social support;sociodemographics;Solid;Source;Testing;therapy development;treatment as usual;United States;usability;Weight;Woman;Work

PROJECT_TITLE: Caring for Bebe: Early Childhood Obesity Prevention Intervention for Hispanic Families


NIH_SPENDING_CATS: Neurosciences;Urologic Diseases

ORG_CITY: MELBOURNE

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: UNIVERSITY OF MELBOURNE

PHR: PROJECT NARRATIVE This project will develop new atlas resources for the research community, to enhance understanding of the vascular system that maintains tissue health within the lower urinary tract. This foundational knowledge base will provide the opportunity to develop new hypotheses on mechanisms of (and solutions for) vascular dysregulation or disruption in clinical conditions (e.g; diabetes, pelvic congestion syndrome).

PI_NAMEs: KEAST, JANET R (contact);OSBORNE, PEREGRINE BLAKE

PROJECT_TERMS: 3-Dimensional;Address;Adult;Anatomy;Atlases;Axon;Bladder;Bladder Control;Blood Vessels;Clinical;Clinical Medicine;Communities;Complex;Computer Models;Custom;Data;Data Collection;Databases;design;Development;Diabetes Mellitus;Dimensions;Disease;Embryo;Environment;Epithelium;FAIR principles;Female;Fluid Balance;Foundations;Ganglia;Generations;Graph;Growth;Health;human data;immature animal;Immunologic Surveillance;Knowledge;knowledge base;Lectin;Life Cycle Stages;Light;Literature;Lower urinary tract;Lymphatic;male;Maps;Methodology;Methods;Microscopy;multi-scale atlas;Mus;Muscle;Nerve;Nerve Plexus;nerve supply;neural;neurovascular;novel strategies;Organ;Outcome;Output;Pattern;Pelvis;Perfusion;Pregnancy;prepuberty;pressure;Regulation;Research;Resolution;Resources;Rodent;Sampling;Sensory;Source;Stretching;Structure;Syndrome;System;Thick;Three-Dimensional Image;Time;Tissue Engineering;Tissues;tool;Urethra;urinary bladder neck;Validation;Vascular System;Venous;Venous system;Viral;Visualization;Weaning

PROJECT_TITLE: Building a multi-scale vascular atlas of the mouse lower urinary tract


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE: The Immunobiology of Rheumatic Diseases Training Program has the singular goal of training basic and clinical investigators to be successful and qualified in carrying out research that benefits patients suffering from rheumatic diseases. Through this program, MD, PhD, and MD/PhD postdoctoral trainees are mentored by established investigators who are actively involved in cutting edge immunology and rheumatic disease research.

PI_NAMEs: COOPER, MEGAN ANNE;LENSCHOW, DEBORAH J (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Immunobiology;Rheumatism

PROJECT_TITLE: Immunobiology of the Rheumatic Diseases


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARATIVE This research is focused on eliciting a novel class of antibodies that can prevent infections by the majority of influenza strains. Immunization regimens developed and validated in this proposal could provide universal protection against influenza viruses by vaccination. Thus, the proposed research is relevant to part of the NIH’s mission that pertains to protecting and improving health by preventing disease.

PI_NAMEs: AZOITEI, MIHAI LUCHIAN (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: Affinity;Animal Model;Animals;Antibodies;Antigens;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Binding Sites;Breathing;Computer Models;Computing Methodologies;cross reactivity;design;Development;Disease;emerging virus;Engineering;Environment;Epitopes;Exhibits;Ferrets;glycosylation;Goals;Grant;Head;Health;Hemagglutinin;high throughput screening;Human;Immune;Immune response;Immunization;Immunodominant Epitopes;immunogenic;immunogenicity;improved;in vivo;Individual;Infection prevention;Influenza;Influenza vaccination;influenza virus strain;influenza virus vaccine;influenzavirus;insight;Lead;Libraries;Link;Methods;Mission;Modeling;Molecular;Molecular Conformation;monomer;Mus;Mutation;mutation screening;novel;novel vaccines;Outcome;Pathway interactions;prevent;Property;Proteins;receptor binding;Regimen;Research;response;Sampling;scaffold;Scaffolding Protein;screening;Serum;Site;Specificity;stem;Structure;success;Surface;Testing;United States National Institutes of Health;universal influenza vaccine;universal vaccine;Vaccinated;Vaccination;vaccine trial;Viral;Virus;Work

PROJECT_TITLE: Novel Immunogens to Elicit Broadly Cross-reactive Antibodies That Target the Hemagglutinin Head Trimer Interface

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Gene Therapy;Genetics;Hematology;Orphan Drug;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: BOSTON

PHR: PROJECT NARRATIVE Hematopoietic gene therapy has emerged as a transformative disease-modifying option for Sickle Cell Disease. Obtaining a sufficient dose of peripheral blood stem cells is paramount to the success of gene therapy. This proposal outlines an efficient microfluidic technology for stem cell isolation from patients with sickle cell disease.

PI_NAMEs: MISHRA, AVANISH  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Address;Advisory Committees;Affect;American;Animal Model;Antibodies;Autologous;Biomedical Engineering;Blood;Blood Cells;Blood Component Removal;Blood Platelets;blood product;Blood specimen;Boston;Cancer Diagnostics;Cannulations;Catheters;CD34 gene;Cell Separation;Cell Therapy;Cells;Characteristics;Circulation;Clinical;Collection;Committee Members;Computer Models;cost;Disease;Dose;Engineering;Engraftment;Epitopes;feasibility testing;Funding;gene therapy;Genes;Goals;Hematocrit procedure;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hemoglobinopathies;Hour;Human;Immunodeficient Mouse;Immunotherapy;in vivo;Individual;Inherited;instrument;Interphase Cell;Kinetics;Label;Lead;Leukocytes;Magnetism;manufacture;Mentors;Methods;Microfluidic Microchips;microfluidic technology;Microfluidics;migration;Modeling;Molecular;mouse model;Mus;nano;nanoparticle;Nature;Pathology;Patients;Pediatric Hospitals;Peripheral;Peripheral Blood Stem Cell;Persons;Platelet aggregation;Process;programs;Research;Research Personnel;Research Proposals;Residual state;Resource-limited setting;Sickle Cell;Sickle Cell Anemia;skills;Sorting;stem cell biology;stem cell gene therapy;stem cell technology;Stem cell transplant;stem cells;success;Surface;Technology;technology development;Testing;therapeutic genome editing;Thrombophilia;Time;tissue culture;Training;Translating;United States;United States National Institutes of Health;Work;Xenograft procedure

PROJECT_TITLE: Precision Apheresis: stem cell isolation from patients with sickle cell disease for gene therapy using high-throughput microfluidics

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(MA)]


NIH_SPENDING_CATS: Bioengineering;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Transplantation;Wound Healing and Care

ORG_NAME: FESARIUSTHERAPEUTICS, INC.

PHR: NARRATIVE When autologous tissue is not available or split thickness skin grafts alone are used, full thickness skin loss may not heal or will heal by contracture of the surrounding skin. Current treatment approaches including engineered off the shelf products have significant limitations, including slow, inconsistent, and inadequate tissue formation, hence impaired wound healing. The commercialization of DermiSphereTM is expected to improve clinical practice in surgical fields where full thickness skin loss is common including, but not limited to, trauma, burns, and post- oncologic reconstructive surgery, by significantly decreasing the time required to achieve a healed wound, as well as increasing the thickness of the regenerated dermis in a scenario of full thickness skin loss.

PI_NAMEs: SAPIR LEKHOVITSER, YULIA  (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: Address;Anatomy;angiogenesis;Animal Model;Animals;Autologous;Autologous Transplantation;biomaterial compatibility;Burn injury;Care given by nurses;Cells;Cellular Infiltration;Clinical;clinical practice;clinically relevant;commercialization;Complication;Contracts;Contracture;Cues;Cyclic GMP;Data;Dermal;Dermis;design;design verification;Engineering;Esthetics;Excision;Expenditure;first-in-human;flexibility;Formulation;Freezing;healing;Healthcare;Human;Hypertrophic Cicatrix;Immobilization;Impaired wound healing;improved;Incidence;Infection;infection risk;Infiltration;innovation;Intention;Interview;Invaded;Lateral;manufacturing organization;Marketing;Morbidity - disease rate;Natural regeneration;Operative Surgical Procedures;Outcome;Patients;Performance;Phase;porcine model;prevent;Procedures;Process;product development;Reconstructive Surgical Procedures;regenerative;resilience;Resources;revascularization;scaffold;Site;Skin;Skin graft;skin regeneration;Small Business Innovation Research Grant;standard care;Surgeon;Technology;Technology Transfer;Tendon structure;Testing;Therapeutic;Thick;Thinness;Time;Tissues;Trauma;Validation;validation studies;Vascularization;Work;wound;wound bed;wound healing

PROJECT_TITLE: An Advanced Dermal Regeneration Scaffold for Reconstructive Surgery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-S(11)B]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: AMHERST

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE In Ghana, where sexual minorities are criminalized, men who have sex with men bear the highest HIV burden, with a prevalence of 18.0%, yet, only 3.7% of HIV-positive MSM are on antiretroviral therapy—a gap found throughout Africa. Theory-based inquiry into the multilevel HIV treatment needs of African MSM living with HIV can inform scalable, efficacious interventions and adaptation with input from community. This study proposes to integrate intersectionality and minority stress theory and operationalize measures to examine how intersectional social stressors affect mental health and HIV treatment outcomes among Ghanaian MSM living with HIV and to develop an intervention to mitigate factors on this pathway to improve health.

PI_NAMEs: GYAMERAH, AKUA OFORI (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Address;Affect;Africa;African;AIDS prevention;Alcohol consumption;antiretroviral therapy;Behavior;care seeking;Caring;cognitive interview;Communities;community engagement;coping;Cross-Sectional Studies;design;Disparity;efficacious intervention;Equation;ethnic identity;evidence base;experience;Feedback;Feeling suicidal;Focus Groups;Future;Gays;Gender;Gender Identity;General Population;Ghana;Goals;Health;health disparity;Health Professional;HIV;HIV disparities;HIV Seropositivity;Homosexuality;implementation barriers;improved;informant;Interruption;intersectionality;Intervention;Intervention Trial;Interview;Knowledge;Link;marginalization;Measurement;Measures;Mediating;Mediation;men who have sex with men;Mental Depression;Mental Health;Methodology;Methods;minority scientist;minority stress;Modeling;Nigerian;novel;Outcome;Pathway interactions;Performance;pilot test;Population;Population Intervention;Prejudice;Preparation;Prevalence;protective factors;Provider;Qualitative Research;Research;Role;Same-sex;service engagement;Sexual and Gender Minorities;sexual identity;sexual minority;sexual violence;Sexuality;Shapes;skills;social stigma;social stressor;social structure;Social support;Social Workers;starfish sampling;Statistical Methods;stressor;suicidal;surveillance data;Testing;theories;therapy design;therapy development;Training;Treatment outcome;Underrepresented Minority;verbal;Violence;Work

PROJECT_TITLE: Intersectional minority stress, mental health, and HIV treatment and care among MSM living with HIV in Ghana

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Arthritis;Bioengineering

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Narrative Hemiarthroplasty, as opposed to total joint arthroplasty, provides a clear benefit in the treatment of degenerative osteoarthritis because it preserves healthy portions of the joint to maximize future treatment options. Currently, hemiarthroplasty is underutilized because artificial bearing surfaces are not optimized, leading to damage of the apposing articular surface. The specific objective of this project is to combine benchtop and ex vivo testing to predict the response of cartilage to hemiarthroplasty bearing systems. If successful, the results of this work will significantly advance hemiarthroplasty treatments.

PI_NAMEs: CRISCO, JOSEPH J (contact);WIMMER, MARKUS ANTON

PROJECT_TERMS: Acceleration;Alloys;Animal Model;Articulation;Biocompatible Materials;Biological Assay;bone;Bone Spur;Bovine Cartilage;Cartilage;Cartilage Matrix;cell injury;Cell Survival;Cells;Ceramics;Characteristics;Chromium;Cobalt;Consensus;cortical bone;Data;Degenerative Disorder;Degenerative polyarthritis;design;Development;Disease;Distal;Equation;Failure;Family suidae;foot;Future;Gait;Glycosaminoglycans;Goals;Hardness;Harvest;Health;Hip region structure;Histopathology;Hydroxyproline;improved;in vivo;Individual;Ions;joint destruction;Joints;Knee;Life;Linear Models;Materials Testing;Measures;mechanical properties;Mechanics;Metabolism;Metals;Methodology;Microscopic;Miniature Swine;Modeling;Modulus;Molybdenum;Motion;novel;Osteogenesis;Outcome;Outcome Measure;outcome prediction;Patients;Performance;performance tests;Polymers;porcine model;Preclinical Testing;predicting response;preservation;primary outcome;programs;Proteoglycan;Proxy;pyrolytic carbon;Replacement Arthroplasty;Reporting;Research;response;Roentgen Rays;Sampling;secondary outcome;Shoulder;spatiotemporal;Standardization;Statistical Models;success;Surface;Synovitis;System;Testing;Thick;Tissues;Titanium;tool;Toxic effect;Wettability;Work;Wrist

PROJECT_TITLE: Advancing Hemiarthroplasty: Predicting in vivo performance of cartilage bearing systems through benchtop and ex vivo testing.

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: NARRATIVE While 98-99% of the human genome is non-coding, these sequences are integral to the control of gene expression giving rise to phenotypic differences between tissues, individuals, species, and healthy and diseased states. Approximately half of human non-coding sequence is annotated as transposable elements that have largely been ignored in genomic studies; yet have the potential to impact complex diseases such as cancer and cardiovascular disease. This proposal focuses on understanding the role of transposable elements in contributing to phenotypic differences arising during cell state transitions and in response to stress within humans and our closest evolutionary relatives.

PI_NAMEs: WARD, MICHELLE CLAIRE (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Binding;biological adaptation to stress;Cardiovascular Diseases;Cell Culture Techniques;cell type;Cells;Cellular Assay;Cellular Stress;chromatin modification;Complex;Disease;DNA Methylation;DNA Transposable Elements;Elements;Environment;Evolution;flexibility;functional genomics;Gene Expression;Gene Expression Regulation;Genes;Genome;Genomic approach;Genomics;Germ Layers;Human;Human Genome;Individual;induced pluripotent stem cell;induced pluripotent stem cell technology;innovation;insight;Junk DNA;Malignant Neoplasms;Mediating;Modeling;Molecular;new technology;novel strategies;Organism;Pan Genus;Phenotype;Prevalence;Primates;Regulation;Regulatory Element;Research;response;Role;Specific qualifier value;Stress;System;Tissues;transcription factor;Untranslated RNA;Work

PROJECT_TITLE: Dynamic regulatory impact of human transposable elements on gene expression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]