ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: TUCSON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Atrial fibrillation (AF) leads to high health economic burden of >$15 billion for new onset AF and an annual cost of $6.65 billion for the care of these patients. Improved identification of risk factors from multimodal data can help select patients who will most benefit from invasive therapy, thus providing a cost-effective approach to management of AF.

PI_NAMEs: CHIAMVIMONVAT, NIPAVAN  (contact);FILKOV, VLADIMIR ;SRIVATSA, UMA

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: 3-Dimensional;Ablation;Acids;acute coronary syndrome;Age Years;Aging;aging population;Algorithms;Anti-Inflammatory Agents;Anticoagulation;Antiinflammatory Effect;Arachidonic Acids;Area;Arrhythmia;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence method;Atrial Fibrillation;Biological;Biological Markers;Blood;Blood specimen;Cardiovascular Diseases;Caring;Catheters;CCL11 gene;CCL2 gene;CCL3 gene;CCL4 gene;chemokine;Clinical;Clinical Data;Clinical Trials;Code;cohort;Color;comorbidity;Complex;Consent;Consumption;convolutional neural network;cost;cost effective;CXCL10 gene;Cytochrome P450;cytokine;Data;Data Analyses;data modalities;Data Science;Data Set;density;Diabetes Mellitus;Dinoprostone;Disease;Economic Burden;Electrodes;Enrollment;Epoprostenol;Evolution;Fibrosis;flexibility;Fractionation;Goals;health economics;Heart Atrium;Heart failure;Hospitalization;human old age (65+);Hypertension;Image;improved;Inflammation;Inflammatory;inflammatory marker;Interleukin-1;Interleukin-10;Interleukin-11;Interleukin-13;Interleukin-4;Interleukin-6;Intracardiac abnormalities;Investigation;Label;Learning;Left;Left atrial structure;Leukotrienes;Linoleic Acids;Lipoxygenase;Logistic Regressions;Lung Diseases;Machine Learning;machine learning model;Maps;Measurement;Measures;metabolomics;Methods;Modeling;Modification;Molecular;Morbidity - disease rate;Morphology;mortality risk;multimodal data;multimodal learning;multimodality;Myocardium;neutrophil;Obesity;Outcome;Pathogenesis;Pathway interactions;Patient Selection;Patient-Focused Outcomes;Patients;Pharmacologic Substance;predictive modeling;Prevention;Procedures;Prognosis;Property;prospective;Prostaglandin-Endoperoxide Synthase;Prostaglandins;random forest;RANTES;Recurrence;Refractory;Risk;Risk Factors;risk prediction model;Risk Reduction;Sensitivity and Specificity;Severities;Signal Transduction;Sinus;Site;Sleep Apnea Syndromes;Spatial Distribution;Stroke;Symptoms;Techniques;Testing;therapeutic target;Thromboxanes;Time;TNF gene;Translating;Treatment Failure;voltage

PROJECT_TITLE: Molecular Mechanisms of Atrial Fibrillation: A Multimodal Analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-C(02)]


ACTIVITY: ZIA

ADMINISTERING_IC: CL

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: CLINICAL CENTER

ORG_NAME: CLINICAL CENTER

PI_NAMEs: SOLOMON, STEVEN  (contact)

PROJECT_TERMS: Adhesions;Adverse effects;Affinity;Age;Alveolar;Anemia;Animals;Antibiotics;Bacteria;Bacterial Infections;Bacterial Pneumonia;Binding;Blinded;Blood;Blood Banks;Blood donor;Blood Transfusion;canine model;Canis familiaris;Carbohydrates;Cardiac;Cardiac Output;Cell model;Cell Survival;Cells;Cessation of life;Chromium;Clinical;Clinical Medicine;Clinical Trials;clinically relevant;Complex;Critical Illness;Cryopreservation;Data;design;Development;Dose;Endothelial Cells;Endothelium;Erythrocyte Transfusion;Erythrocytes;experimental study;Filtration;glycosylated-nitric oxide complex hemoglobin A;Growth;Haptoglobins;Hematological Disease;hemodynamics;Hemoglobin;Hemoglobin concentration result;Hemolysis;Hemorrhage;Hemorrhagic Shock;Histologic;Hour;Human;improved;improved outcome;in vivo;Infection;Inflammation;Inflammatory;Infusion procedures;Injury;intravenous administration;Iron;Lesion;Life;life span;Lipids;Liver;liver function;Lung;lung injury;lung pressure;Measurable;Measures;Membrane;Metabolic;microvesicles;Modeling;Modernization;mortality;mortality risk;Nitric Oxide;Norepinephrine;Nutrient;Operative Surgical Procedures;organ injury;Outcome;oxidative damage;Oxygen;Oxyhemoglobin;Pathogenesis;patient population;Patients;Performance;Plasma;Plasma Cells;Pneumonia;pneumonia model;Poison;Polyvinyl Chloride;Population;Potassium;pre-clinical;Preparation;pressure;prevent;Proteins;Randomized;randomized, controlled study;Recovery;Refrigeration;Reperfusion Therapy;response;Risk;Risk Marker;Role;Sepsis;septic;Septic Shock;Severities;Shapes;Shock;Sickle Cell Anemia;Staphylococcus aureus;Survival Rate;Temperature;Testing;Thalassemia;Time;tissue injury;Toxin;Transfusion;Trauma;trend;unethical;United States;vasoconstriction;Virulent;Work

PROJECT_TITLE: Is there a difference between transfusing old vs fresh blood in critical illness


PROJECT_TERMS: Acute;Adult;Animal Model;Animals;Biochemical;biological adaptation to stress;Blood;Blood Pressure;Blood Vessels;Cardiac;Cardiac Edema;cardiac magnetic resonance imaging;Cardiac Output;Cardiomyopathies;Catecholamines;Cessation of life;Colloids;comparative;Consensus;Contracts;crystalloid;design;Development;Dimensions;Drops;Echocardiography;Edema;EFRAC;Electron Microscopy;Epinephrine;Exclusion;experience;falls;Functional disorder;Heart;Heart failure;heart function;Heart Injuries;hemodynamics;Histologic;Hour;Human;Hypotension;Immune system;Impairment;Infection;Infusion procedures;insight;Ischemia;Left;Left Ventricular Ejection Fraction;Left Ventricular Mass;Left ventricular structure;light microscopy;Liquid substance;Low Cardiac Output;Magnetic Resonance Imaging;Maintenance;Modeling;Multiple Organ Failure;Muscle Cells;Myocardial;Myocardial dysfunction;novel;Patients;pediatric patients;Perfusion;Peripheral;pneumonia model;pressure;Protocols documentation;Randomized;Recovery;Recovery of Function;reparative capacity;reparative process;Resistance;response;restoration;Resuscitation;Sedation procedure;Sepsis;septic;Septic Shock;Shock;Stress;Stress cardiomyopathy;Survivors;Syndrome;Testing;Therapeutic;Thinness;Time;Tissues;Toxic effect;Troponin;vascular injury;ventilation;Ventricular;Water

PROJECT_TITLE: The Comparative Pathobiology of Stress-induced and Sepsis-induced Cardiomyopathy


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PI_NAMEs: BROOKS, BERNARD R (contact)

PROJECT_TERMS: Acceleration;aerosolized;Algorithms;Amber;Amino Acid Sequence;Anisotropy;Binding;Biochemistry;Biological;Chemicals;Classification;Communities;Complex;Computational Technique;Computer software;Computing Methodologies;cost;Data;deep learning;density;Dependence;Disease;disease-causing mutation;Docking;Elasticity;Electron Microscopy;electron tomography;Energy consumption;experimental study;Fluorescence Resonance Energy Transfer;Gases;Goals;heuristics;Homologous Protein;Hybrids;Image;improved;Infusion procedures;Knowledge;Lasers;Lead;Liquid substance;Location;Machine Learning;macromolecular assembly;macromolecule;Maps;Mass Spectrum Analysis;Methods;Modeling;models and simulation;Modernization;Molecular;molecular assembly/self assembly;Molecular Conformation;molecular modeling;molecular size;Molecular Structure;Monte Carlo Method;Movement;nanoparticle;nanorod;neural network;NMR Spectroscopy;Normal Statistical Distribution;Output;particle;Pathway interactions;Pattern Recognition;peptide structure;Physics;Physiologic pulse;Property;protein folding;Protein Region;protein structure;protein structure prediction;Proteins;Research;Research Support;Resolution;Roentgen Rays;Sampling;Sequence Alignment;Shock;Signal Transduction;simulation;Source;Spectrum Analysis;Statistical Computing;structural biology;Structure;System;Techniques;Technology;Temperature;Tertiary Protein Structure;three dimensional structure;Time;tomography;tool;Variant;Work;X-Ray Crystallography;x-ray free-electron laser

PROJECT_TITLE: Three-dimensional Structures Of Biological Macromolecules


NIH_SPENDING_CATS: Bioengineering;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Networking and Information Technology R&D (NITRD);Neurosciences

PROJECT_TERMS: Action Potentials;Active Sites;Address;Affect;Agreement;alpha-bungarotoxin receptor;Antibiotic Resistance;Basic Science;Behavior;Binding;Biological;Biological Process;biophysical properties;Biophysics;Blindness;blood treatment;Brain;cancer therapy;Cell division;Cell membrane;Cells;Cellular Membrane;Charge;Chemicals;Chemotaxis;cholinergic;Communication;Complex;Computational Biology;Computer Models;Computer Simulation;Cooperative Behavior;Coupled;CRISPR/Cas technology;Cytoskeleton;Data;Dependence;design;Development;Differential Equation;dimer;DNA;DNA Binding;DNA biosynthesis;DNA Primase;drug discovery;electric field;Electron Microscopy;Electrophysiology (science);Electrostatics;Engineering;Environment;Enzymes;evaluation/testing;Extracellular Domain;Free Energy;Gangliosides;Gene Expression Microarray Analysis;Gene Expression Profiling;Genetic;Glycine Receptors;Glycolipids;Growth;Guanosine Triphosphate;Hematological Disease;Histones;Hodgkin-Huxley model;Hydrogen Bonding;Hydrolysis;Image Analysis;improved;insight;interest;Ion Channel;Ion Channel Gating;Ions;Iron;Kinetics;Laboratories;Lateral;Ligands;Lipid Bilayers;Lipids;macromolecule;Malignant Neoplasms;Measures;Membrane;Methods;Microtubules;Modeling;Molecular;Molecular Conformation;molecular dynamics;molecular mechanics;molecular modeling;monomer;Monte Carlo Method;mutant;National Heart, Lung, and Blood Institute;Natural regeneration;Nervous System;oxidation;Oxidation-Reduction;Pharmaceutical Preparations;Phase;phospho-L-arginine;Play;Polysaccharides;Positioning Attribute;Process;programs;Proteins;Quantum Mechanics;Radial;Reaction;receptor;Research;Research Project Grants;RNA;RNA primers;Role;Rotation;Running;Sampling;Science;Scientist;Side;Sigmoid colon;Signal Transduction;Signaling Protein;simulation;small molecule;Speed;Statistical Models;Streptococcus pyogenes;Stroke;Structure;Sulfur;Surface Tension;System;Techniques;Testing;Thermodynamics;Time;time use;tool;trafficking;Transmembrane Domain;transmission process;Tubulin;Variant;Work;wound healing

PROJECT_TITLE: Molecular Dynamics Simulations Of Biological Macromolecules


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Active Sites;Algorithms;Amber;Amino Acid Sequence;Area;Basic Science;Behavior;Binding Sites;Biochemical Pathway;Biochemical Process;Biochemical Reaction;Biological;Biological Process;Biological Products;biological systems;Biophysics;Catalysis;Cells;chemical property;Chemicals;cofactor;Communities;Computational Biology;Computational Technique;Computer Assisted;Computers;Computing Methodologies;computing resources;Coupled;Crystallography;Custom;Data;Data Set;Databases;Decision Trees;Descriptor;design;Development;Drug Design;Elasticity;Electron Microscopy;Electron Transport;electronic structure;Electrons;Electrostatics;Ensure;Enzymes;Equilibrium;evaluation/testing;experimental study;Free Energy;Freedom;Frequencies;functional group;Gene Expression Microarray Analysis;Gene Expression Profiling;gene function;Generations;Goals;Grain;Graph;Hardness;Health;Human;human disease;Image;Image Analysis;improved;induced pluripotent stem cell;interest;Ions;Iron;Laboratories;Ligands;Linear Regressions;Link;Machine Learning;machine learning model;machine learning prediction;macromolecule;Manuals;Maps;Measurement;Membrane Proteins;metallicity;metalloenzyme;Metalloproteins;Metals;Methodology;Methods;Modeling;models and simulation;Molecular;molecular dynamics;molecular mechanics;molecular modeling;multi-scale modeling;Names;National Heart, Lung, and Blood Institute;neural network classifier;novel;Nucleic Acids;oxidation;Oxidation-Reduction;Oxygen;parallelization;Pathway Analysis;Pharmaceutical Preparations;photosystem II;Physiological;Play;programs;Property;protein data bank;Protein Databases;Proteins;Pythons;quantum;Quantum Mechanics;Radial;Radiation induced damage;Reaction;Recommendation;Reporting;Research;Research Project Grants;Resources;Roentgen Rays;Role;Science;Scientist;simulation;Site;small molecule;software development;Solvents;Specificity;Structure;Sulfur;Surface;System;Techniques;Temperature;Testing;text searching;theories;Therapeutic Intervention;therapeutic lead compound;therapy design/development;tool;Update;Validation

PROJECT_TITLE: Development Of Theoretical Methods For Studying Biological Macromolecules


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PI_NAMEs: HONG, SO GUN  (contact)

PROJECT_TERMS: Address;Antibodies;Antibody-drug conjugates;Autologous;Behavior Therapy;Biological Models;Blood Component Removal;Bone Marrow;Cardiac;Cardiac Myocytes;Cell Therapy;cell type;Cells;Clinical Research;Clonality;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Communication;conditioning;CRISPR/Cas technology;Disease;Dose;Engraftment;enhanced green fluorescent protein;Erythrocytes;Extramural Activities;fertility preservation;Future;Gene Expression;Gene Modified;gene therapy;Gene Transfer;Genes;Genetic;Goals;Growth;Health;Heart Diseases;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Mobilization;Hematopoietic stem cells;Hemoglobin;Human;human subject;Immune;immune reconstitution;Immunology;improved;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;innovative technologies;insight;Iodides;Journals;lentivirally transduced;Lentivirus Vector;life span;Longevity;Macaca mulatta;Macrophage;Methodology;Methods;Modality;Modeling;Modification;National Institute of Allergy and Infectious Disease;Nature;non-invasive imaging;nonhuman primate;novel;Pluripotent Stem Cells;Population;Positron-Emission Tomography;post-transplant;Pre-Clinical Model;preclinical development;Primates;programs;Proto-Oncogene Protein c-kit;Publishing;reconstitution;regenerative therapy;Regimen;Reporter Genes;Reporting;Resources;Retroviral Vector;Rhesus;risk/benefit ratio;Rodent;Rodent Model;Safety;Sodium;stem cell biology;stem cells;symporter;T-Lymphocyte;Technology;Testing;therapeutic development;therapeutic gene;therapy design;Tissues;transduction efficiency;Transplantation;Transplantation Conditioning;Universities;vector;Washington

PROJECT_TITLE: Genetic Modification and Novel Cell Therapies in Non-Human Primate Hematopoietic Cells


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Precision Medicine;Rare Diseases

PI_NAMEs: WIESTNER, ADRIAN U (contact)

PROJECT_TERMS: acquired drug resistance;Adaptor Signaling Protein;Adhesions;Agammaglobulinaemia tyrosine kinase;B-Cell Activation;B-Cell Antigen Receptor;Binding;Biological;Bone Marrow;candidate validation;Cells;Chronic Lymphocytic Leukemia;chronic lymphocytic leukemia cell;Classification;Clinical;Clinical Trials;cohort;Complex;Conduct Clinical Trials;CXCR4 gene;Data;Data Correlations;disorder risk;Dose;Enrollment;Event;exome sequencing;experience;follow-up;Gene Expression Profiling;Gene set enrichment analysis;genetic signature;Globulins;Hour;Immunity;improved;In complete remission;in vivo;Inferior;inhibitor;inhibitor therapy;Innovative Therapy;Integrin alpha4beta1;Intervention;Lactate Dehydrogenase;Link;lymph node microenvironment;lymph nodes;Lymphocytosis;Macrophage;Mantle Cell Lymphoma;Mature B-Lymphocyte;Measures;Mediating;memory CD4 T lymphocyte;Minor;Modality;Modeling;Molecular;Multivariate Analysis;mutant;Mutation;Mutation Detection;nanomolar;neoplastic cell;NF-kappa B;NFKB Activation Pathway;novel strategies;Oncogenic;Outcome;participant enrollment;Pathogenesis;Pathogenicity;Pathway interactions;patient stratification;Patients;peripheral blood;PF4 Gene;Pharmaceutical Preparations;phase 2 study;Phase II Clinical Trials;PLCG2 gene;population based;pre-clinical;Pre-Clinical Model;prevent;Process;prognostic;Prognostic Marker;prognostic model;prognostic significance;prognostic value;progression risk;Proliferating;prospective;Proteins;Receptor Signaling;Recording of previous events;recruit;Reporting;Resistance;response;Risk;RNA;Role;Sampling;Shapes;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;Subgroup;Systems Biology;T-cell inflamed;T-Lymphocyte;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;therapy resistant;Time;TP53 gene;transcriptome;transcriptome sequencing;transcriptomic profiling;treatment response;tumor;tumor microenvironment;Tumor-Derived Activated Cell;Tyrosine Kinase Inhibitor;ubiquitin-protein ligase;Validation

PROJECT_TITLE: Tumor microenvironment in CLL and MCL: pathogenesis, targets, and therapy


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

PI_NAMEs: RODGERS, GRIFFIN  (contact)

PROJECT_TERMS: 13q12;13q14;14q;Adult;advanced prostate cancer;American;Anterior;Bioinformatics;Biological;Biological Process;BRCA2 gene;C57BL/6 Mouse;Cadherins;Cancer Cell Growth;Cancer Etiology;cancer type;Cathepsins;Cell Adhesion;Cell Physiology;Cell Proliferation;Cell surface;Cells;Cessation of life;Chromosomes;Colon Carcinoma;Colonic Neoplasms;Development;Diagnosis;Ectopic Expression;Epithelial Cells;Epithelium;Evaluation;Exons;Family;Family member;forkhead protein;FOXO1A gene;Gene Expression Regulation;Genes;Genitourinary system;Goals;Homeostasis;Human;Human Genome;improved;In Vitro;in vivo;Inflammation;Invaded;Lectin;Loss of Heterozygosity;male;Malignant Breast Neoplasm;Malignant neoplasm of prostate;malignant stomach neoplasm;Mediating;men;Messenger RNA;Metadata;Metastatic Neoplasm to the Bone;Modeling;Molecular;Mus;Natural Immunity;Neoplasm Metastasis;novel;olfactomedin;OLFM4 gene;Organoids;postnatal development;Prognosis;Proliferating;Prostate;prostate cancer cell;prostate cancer progression;Prostatic Epithelium;Prostatic Neoplasms;Proteins;RB1 gene;Reporter;Reporting;Retinoblastoma;Seminal fluid;Serum;Signal Pathway;single-cell RNA sequencing;Solid Neoplasm;Stomach Neoplasms;Stromal Cell-Derived Factor 1;Susceptibility Gene;three dimensional cell culture;Tissues;Tube;Tumor Suppressor Genes;Tumor Suppressor Proteins;Up-Regulation;Urethra;Xenobiotic Metabolism

PROJECT_TITLE: Olfactomedin 4 Suppresses Prostate Cancer Cell Growth and Metastasis via Negativ


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Rare Diseases;Stomach Cancer

PROJECT_TERMS: Affect;alpha-latrotoxin receptor;Amino Acid Sequence;Apoptosis;Attenuated;cancer cell;CDC2 gene;Cell Cycle;Cell Cycle Arrest;Cell Cycle Progression;Cell Proliferation;Cells;Co-Immunoprecipitations;Colonic inflammation;CSF3 gene;cyclin B1;Down-Regulation;Epithelium;experimental study;Family;G2/M Arrest;Gastric Adenocarcinoma;gastric cancer cell;gastrointestinal infection;Genes;Glycoproteins;Granulocyte Colony-Stimulating Factor;Hematopoietic;Human;In Vitro;in vivo;Inflammation;Inflammatory Bowel Diseases;Interferons;knock-down;Laboratories;Link;M cell;Malignant Neoplasms;malignant stomach neoplasm;Mediating;member;MicroRNAs;Molecular;Mucous Membrane;Myelogenous;Natural Immunity;neutrophil;Noelin-1;nucleocytoplasmic transport;Nude Mice;olfactomedin;OLFM4 gene;Oncogenic;overexpression;Play;precursor cell;Proliferating;Proteins;Regulation;Reporting;Role;Small Intestinal Adenocarcinoma;therapeutic target;Translations;Tretinoin;tumor;tumor growth;ubiquitin-protein ligase;Yeasts

PROJECT_TITLE: Olfactomedin 4- a key regulator of human neutrophil function, role in small intestinal adenocarcinoma.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cancer;Dementia;Genetics;Hematology;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PROJECT_TERMS: Abeta clearance;Actins;Address;Alzheimer's Disease;Amyloid beta-42;Amyloid beta-Protein;Biological;Biological Process;Blood;Categories;Cell Lineage;Cell Surface Receptors;cell type;Cells;Clinic;Data;Development;Disease;Dysmyelopoietic Syndromes;Erythroid;Exposure to;Functional disorder;Gene Expression Profile;Gene Expression Profiling;gene product;Genes;Genetic Transcription;Glia Maturation Factor;Global Change;Granulopoiesis;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Immune;inhibiting antibody;insight;knock-down;leukemia;Leukemic Cell;Link;Liquid substance;Macrophage;MAPK8 gene;Maps;Mediating;Methods;Microglia;monocyte;Mus;Mutation;Myelogenous;Myeloid Progenitor Cells;Myeloproliferation;novel;Nuclear Pore Complex;Oncogenes;Ontology;overexpression;Peripheral;Phagocytes;Phagocytosis;Phosphorylation;Polyubiquitination;Population;posttranscriptional;prevent;protein expression;Proteins;response;Role;scavenger receptor;Signal Pathway;Signal Transduction;slow potential;stem cell population;Structure;Suggestion;System;Techniques;Therapeutic;Time;tool;transcription factor;Trees;Two-Dimensional Gel Electrophoresis;uptake

PROJECT_TITLE: Glia maturation factor-gamma modulation of signaling pathways in macrophages


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cancer;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Hematology;Immunization;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

PROJECT_TERMS: Affinity;Agreement;Allogenic;anti-CD20;Antibodies;antibody libraries;Antibody Therapy;Antigen Targeting;Antigens;arm;Autologous;B lymphoid malignancy;B-Lymphocytes;BCL2 gene;Binding;biological adaptation to stress;Bispecific Antibodies;Blood;Bone Marrow;cancer immunotherapy;CD19 gene;CD8-Positive T-Lymphocytes;cell killing;Cell Line;Cell surface;cell type;Cells;Cellular Immunity;chemotherapy;chimeric antigen receptor T cells;Chronic Lymphocytic Leukemia;chronic lymphocytic leukemia cell;Clinic;Clinical;clinical development;Clinical Trials;cohort;comparison control;Complement;Complement 3d;Complement Activation;Conduct Clinical Trials;COVID-19 booster;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;Cytolysis;cytotoxic;cytotoxicity;Deposition;Dose;engineered T cells;Epitopes;Evaluable Disease;Fc Receptor;FDA Emergency Use Authorization;Frequencies;Futility;Glycoproteins;Hepatitis B Vaccines;Human;IgG1;Immune response;Immunotherapy;Impairment;improved;In Vitro;in vivo;inhibitor;Injections;Innovative Therapy;insight;Interruption;Intervention;invention;Investigation;Leukemic Cell;Lymphoma;Malignant lymphoid neoplasm;Measures;Mediating;Medical;Modeling;Monoclonal Antibodies;Monoclonal Antibody CD20;Monoclonal Antibody Therapy;mouse model;MS4A1 gene;Multiple Myeloma;Mus;neoantigens;neoplastic cell;novel strategies;open label;Oryctolagus cuniculus;overexpression;pandemic disease;patient derived xenograft model;patient response;Patients;Peripheral Blood Mononuclear Cell;primary endpoint;Progressive Disease;prospective;Reaction;Recombinants;Recommendation;recruit;Reporting;Resistance;response;rituximab;Role;ROR1 gene;Sampling;Secondary Immunization;Series;Serology;sialic acid binding Ig-like lectin;Stem cell transplant;success;T cell differentiation;T memory cell;T-Lymphocyte;Testing;Time;tositumomab;tumor growth;Vaccination;vaccination strategy;vaccine development;vaccine response;vaccine trial;Vaccines;Variant;Work;Xenograft Model;Xenograft procedure;Zoster Vaccine

PROJECT_TITLE: Immunotherapy of low grade lymphoid malignancies


NIH_SPENDING_CATS: Atherosclerosis;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: POWELL-WILEY, TIFFANY  (contact)

PROJECT_TERMS: Academia;acceptability and feasibility;Adult;African American;African American population;African American Women;Agriculture;Amines;Amygdaloid structure;Aorta;Area;Assessment tool;atherogenesis;behavior change;Behavior Therapy;Biological;Biological Aging;Biological Markers;Black church;Blood Vessels;Body Image;Body mass index;Body Size;built environment;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Catecholamines;CCR5 gene;Cessation of life;Characteristics;Chronic;Chronic stress;Church;Clinic;clinical center;Clinical Protocols;Clinical Trials;cohort;Collaborations;Communities;community advisory board;community based participatory research;community collaboration;Community Health;Community Healthcare;community intervention;community partners;Consult;Crime;Data;Data Collection;depressive symptoms;deprivation;design;Diabetes Mellitus;Dietary intake;digital;disorder risk;District of Columbia;Dopamine;Dopamine D2 Receptor;Early identification;Economic Development;Environment;Environmental Risk Factor;Epigenetic Process;Event;experimental study;Faith;Focus Groups;Food;Future;future implementation;Goals;handheld equipment;Health;health assessment;Health behavior;Health behavior and outcomes;health disparity;Health Personnel;Healthcare;Hematopoietic System;High Density Lipoprotein Cholesterol;High Density Lipoproteins;high risk population;hypercholesterolemia;Hyperlipidemia;Hypertension;IL18 gene;Immune;Immunologic Factors;Immunologics;implementation evaluation;improved;In Vitro;Income;indexing;Individual;Inflammation;Interleukin-1 beta;Intervention;Laboratories;LDL Cholesterol Lipoproteins;Leisures;Link;Lipids;Lipoproteins;Location;Low income;low socioeconomic status;Measurement;Measures;Mediating;Mediation;member;Methods;mHealth;microbial;microbiome;mobile application;Modeling;Monitor;monocyte;mortality;Needs Assessment;Neighborhoods;neural;novel;nutrition;Obesity;Obesity Epidemic;obesity prevention;obesity risk;Online Systems;Outcome;Oxides;Participant;Pathogenicity;Pathway interactions;Patients;Perception;phenotypic data;Physical activity;Play;Population;population based;Population Heterogeneity;Populations at Risk;preference;Prevalence;Prevention strategy;Property;Proprotein Convertases;Proteome;Protocols documentation;Proxy;Psychosocial Factor;Psychosocial Stress;receptor;Recommendation;Records;recruit;Research;Research Personnel;Resource-limited setting;Resources;Risk;Risk Factors;Role;Sampling;satisfaction;Scoring Method;screening;sedentary;Serum;Signal Pathway;Signal Transduction;simulation;social cohesion;Social Conditions;social determinants;Social Environment;Socioeconomic Status;socioeconomics;Source;Stress;Subtilisins;Suggestion;Sympathetic Nervous System;System;Target Populations;Technology;technology intervention;Time;TNF gene;tool;United States National Institutes of Health;Universities;uptake;Violence;ward;Washington;wearable data;wearable device;wireless;Work;wristband

PROJECT_TITLE: Cardiovascular Health and Needs Assessment in Washington D.C.


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Clinical Research;Genetics;Hematology;Human Genome;Precision Medicine

PI_NAMEs: JOHNSON, ANDREW  (contact)

PROJECT_TERMS: Accounting;African ancestry;Aging;Alcohols;anti-depressive agents;Area;Atherosclerosis;Biochemical;Bioinformatics;Biological Assay;Biology;Blood;Blood Platelets;Blood Pressure;Boston;calcification;Candidate Disease Gene;Cardiovascular Diseases;Cardiovascular system;Catalogs;Cells;Chromosome Mapping;Circulation;cohort;Collaborations;Communication;Coronary Arteriosclerosis;COVID-19;COVID-19 pandemic;Data;data cleaning;Data Collection;Data Set;Diabetes Mellitus;Disease;disorder risk;DNA;Epidemiologic Factors;Epidemiology;epidemiology study;Epigenetic Process;Event;exome;experimental study;Fibrin fragment D;Fibrinogen;follow-up;Framingham Heart Study;Gene Chips;gene discovery;Gene Expression;Genes;Genetic;genetic analysis;Genetic Databases;Genetic Markers;Genetic study;genome wide association study;Genomics;Genotype;Goals;GRK5 gene;Health;Hemostatic Agents;Human;Individual;Jackson Heart Study;Journals;Knockout Mice;Knowledge;Link;Lipids;Manuscripts;meetings;Megakaryocytes;men;Metabolic Diseases;Micro Array Data;Mus;Nature;new therapeutic target;novel;Oral;Paper;Pathway interactions;personalized medicine;Pharmaceutical Preparations;Plasminogen Activator Inhibitor 1;Platelet Count measurement;platelet function;Population;Population Genetics;Population Heterogeneity;Population Study;Postdoctoral Fellow;Process;programs;Publishing;Puerto Rican;Pulmonary Embolism;repository;Research;Resources;response;Risk Factors;RNA;Role;Sampling;Scanning;Signal Transduction;Stroke;Therapeutic Intervention;therapeutic target;Thrombin;Thrombosis;Tissue-Specific Gene Expression;Tissues;trait;Trans-Omics for Precision Medicine;transcriptome;transcriptome sequencing;treatment response;United States National Institutes of Health;Update;Validation;Variant;Venous;venous thromboembolism;Veterans;Work;Writing

PROJECT_TITLE: Cardiovascular Genomics and Bioinformatics projects


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Gene Therapy;Genetics;Hematology;Nanotechnology;Orphan Drug;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PI_NAMEs: LAROCHELLE, ANDRE  (contact)

PROJECT_TERMS: Acceleration;Address;Adenine;Affect;Agonist;Annual Reports;Antibodies;Antigens;Attenuated;Autologous;Autologous Transplantation;base editing;base editor;Basic Science;Binding;Biodistribution;Biological Assay;Bone Marrow;Bone marrow failure;bone marrow failure syndrome;CCR5 gene;CD34 gene;Cell Nucleus;Cell Physiology;Cells;chemical conjugate;chemotherapy;Chimeric Proteins;Chloroquine;Clinical;clinical efficacy;clinical practice;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Colchicine;conditioning;Confocal Microscopy;cost;CRISPR/Cas technology;cytokine;Cytosol;Defect;Dendrimers;design;Development;Dextran Sulfate;Dichloromethylene Diphosphonate;dimer;Diphtheria Toxin;Disease;disulfide bond;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;dosage;Dose;Double Strand Break Repair;effective therapy;Effectiveness;Electroporation;Eligibility Determination;Encapsulated;endoplasmic reticulum stress;Endosomes;Engineering;Engraftment;Ensure;Enzyme-Linked Immunosorbent Assay;Esters;Evaluation;Event;Exposure to;Face;Fanconi Anemia Complementation Group A Protein;Fanconi's Anemia;fitness;Flow Cytometry;Fluorescence Resonance Energy Transfer;Formulation;gene correction;Gene Delivery;gene delivery system;Gene Modified;gene therapy;gene-editing approach;Genes;Genetic Engineering;genetic manipulation;Granulocyte Colony-Stimulating Factor;Harvest;Hematological Disease;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Hemolysis;Human;Human Herpesvirus 4;Hydrophobicity;Hypersensitivity;Hypoxia;Immune;immunogenicity;Impairment;improved;In Vitro;in vivo;Individual;Inflammation;Inflammation Mediators;Inflammatory;Infusion procedures;Inherited;Inherited bone marrow failure;inhibitor;innate immune pathways;Innate Immune Response;insertion/deletion mutation;insight;integration site;Investigation;lipid nanoparticle;Lipids;Liposomes;Malignant - descriptor;Malignant Neoplasms;manufacture;Marrow;Mediating;Messenger RNA;Methods;Modification;Monitor;Mononuclear;MPL gene;Mus;mutation correction;nanoparticle delivery;Neutropenia;Non-Viral Vector;nonhuman primate;novel;novel strategies;nucleic acid delivery;Nucleic Acids;Organ;Pancytopenia;Participant;Patients;peripheral blood;Phagocytes;phase II trial;Point Mutation;Population;post-transplant;Pre-Clinical Model;Process;programs;Proteomics;Protocols documentation;Reagent;Recombinants;Recovery;Regenerative Medicine;Regimen;Reporter;Reporter Genes;Research;resilience;response;Risk;Role;Safety;self-renewal;sensor;SLC5A5 gene;small molecule;Specialized Center;Stress;System;Tail;Therapeutic;tool;Toxic effect;TP53 gene;transcription factor;transcriptomics;Transformed Cell Line;Translating;Translational Research;Transplantation;Transplantation Conditioning;Transposase;Treatment Factor;vector;Viral;Viral Vector;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Gene Therapy for Inherited Blood Disorders


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Cystic Fibrosis;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases

PI_NAMEs: FENNELLY, KEVIN  (contact)

PROJECT_TERMS: 2019-nCoV;Academia;Address;Aerosols;Affect;airway epithelium;Antibiotics;Attention;Biotechnology;Blood specimen;Bronchiectasis;Bronchoalveolar Lavage;Caring;Characteristics;Chest;Chronic;chronic infection;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;clinical center;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Complex;COVID-19;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Databases;Development;Diagnosis;Disease;Disease Progression;drug development;Drug Targeting;early phase clinical trial;Educational workshop;Environmental Risk Factor;Epithelial Cells;ethnic diversity;Ethnic Population;Foundations;Genetic;Genetic Diseases;Genetic Risk;genetic risk factor;Genomics;Genus Mycobacterium;Geographic Locations;Goals;Guidelines;Hawaiian;Health;heritable connective tissue disorder;High Prevalence;high risk;Home;Host Defense;Human;IgE;Immunocompetent;improved;Incidence;Industry;Infection;Integration Host Factors;interest;Investigation;Island;Lung;Lung Diseases;Lung infections;Marfan Syndrome;Measures;member;Microbe;model development;Modeling;modifiable risk;mortality;mouse model;Mucociliary Clearance;Mus;Mutation;mycobacterial;Mycobacterium avium Complex;Mycobacterium Infections;Mycobacterium tuberculosis;Natural History;new therapeutic target;non-tuberculosis mycobacteria;Nose;novel;Occupations;Organism;Oryctolagus cuniculus;Outcome Measure;Pathogenesis;Pathway interactions;Patient Isolation;Patient Outcomes Assessments;patient population;patient registry;Patients;Penetration;Persons;Pharmaceutical Preparations;Phenotype;Population;Population Study;Population-Based Registry;pre-clinical;Pre-Clinical Model;Predisposition;Prevalence;Primary Ciliary Dyskinesias;Protocols documentation;Pseudomonas;Publishing;Rare Diseases;Regimen;Research;Research Personnel;Resources;Respiratory System;Respiratory Tract Infections;Risk;Risk Factors;risk variant;Role;safety assessment;Site;Societies;Source;Sputum;Standardization;STAT3 gene;Symptoms;Syndrome;Testing;Therapeutic;therapeutic development;therapeutic target;tool;transmission process;Treatment Protocols;Tuberculosis;United States National Institutes of Health;Virulence;Virulence Factors;Virus;Walking;Work;Zebrafish

PROJECT_TITLE: Bronchiectasis and chronic airway infection


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PROJECT_TERMS: 12 year old;Acceleration;Acute Myelocytic Leukemia;Address;Adverse effects;Adverse event;Affect;Allogenic;Alternative Therapies;American Society of Hematology;Androgens;Anemia;Aplastic Anemia;Autologous;Basic Science;Biological Availability;Blood;Bone Marrow;Bone marrow failure;bone marrow failure syndrome;cancer cell;Cell Count;Cells;chelation;Chemotherapy and/or radiation;Child;Childhood;clinical practice;Clinical Trials;clinically significant;Collection;conditioning;CRISPR/Cas technology;cytokine;cytopenia;Data;Defect;design;Disease;Disease Progression;DNA Double Strand Break;Dose;Double Strand Break Repair;Dysmyelopoietic Syndromes;effective therapy;Enrollment;Erythroid;Evaluable Disease;Evaluation;Event;Exhibits;experience;Failure;Fanconi Anemia Complementation Group A Protein;Fanconi's Anemia;Fibrosis;Funding;Future;gene therapy;Genetic;Genome Stability;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Human;Hypersensitivity;improved;indexing;Individual;Inflammation Mediators;Inflammatory;Inherited;Inherited bone marrow failure;insight;Institutional Review Boards;Interferons;Investigation;iron deficiency;iron supplementation;knock-down;Link;Malignant Neoplasms;Marrow;Mediating;mimetics;minimal risk;Molecular;Monosomy 7;neutrophil;Nonhomologous DNA End Joining;Oral;Outcome;Participant;Pathway interactions;patient subsets;Patients;peripheral blood;Pharmaceutical Preparations;Phase I/II Clinical Trial;Platelet Count measurement;Population;progenitor;programs;Property;prospective;receptor;Refractory anemias;Regenerative Medicine;Regimen;repaired;Reporting;Research;Research Personnel;Residual state;response;Risk;Safety;Series;side effect;Signal Induction;Signal Pathway;Signal Transduction;small molecule;Solid;Solid Neoplasm;stem;Stem cell transplant;Therapeutic;Therapeutic immunosuppression;Thrombopoietin;Time;Translating;Translational Research;Transplant Recipients;treatment duration;Withholding Treatment;Work

PROJECT_TITLE: Eltrombopag for the Treatment of Fanconi Anemia


NIH_SPENDING_CATS: Clinical Research;Hematology;Pediatric;Rare Diseases;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: FITZHUGH, COURTNEY  (contact)

PROJECT_TERMS: Academic Medical Centers;Acute;Acute Graft Versus Host Disease;alemtuzumab;Allogenic;Antibodies;Anticoagulation;Autoimmune;Autologous;beta Thalassemia;Bone Marrow Purging;Bone Marrow Transplantation;Brain;CD3 Antigens;Cells;Chicago;Child;Chimerism;chronic graft versus host disease;chronic thromboembolic pulmonary hypertension;Cirrhosis;clinical remission;clinical risk;cohort;Collaborations;conditioning;Congenital Anemia;Control Groups;curative treatments;Cyclophosphamide;Data;Development;Disease;Dose;End stage renal failure;Engraftment;Evans Syndrome;Event;experience;falls;Family member;follow-up;genetic risk assessment;genetic risk factor;Goals;graft failure;Graft Rejection;Graft Survival;graft vs host disease;Health;Heart;Heart Diseases;Heart failure;Hematopoiesis;Hemoglobin;high risk;Hospitals;Human Herpesvirus 4;Illinois;immunoregulation;Immunosuppression;improved;Incidence;Individual;Inflammatory;Infusion procedures;Kidney;Kidney Diseases;Laboratories;Liver;Long-Term Effects;Low Dose Radiation;Lung;Lung Diseases;Lymphoproliferative Disorders;Morbidity - disease rate;mortality;mouse model;Multiple Organ Failure;Mus;Myelogenous;Myeloproliferative disease;Neurocognitive;neurotoxicity;novel;Organ;participant enrollment;Patients;Peripheral Blood Stem Cell;Peripheral Stem Cell Transplantation;personalized approach;Phase;Phase I/II Trial;Phenotype;post-transplant;primary endpoint;Proto-Oncogene Protein c-kit;Protocols documentation;Pulmonary Hypertension;Reaction;Recording of previous events;Refractory;Regimen;Research Personnel;retransplantation;Risk;second transplant;Siblings;Sickle Cell Anemia;sickling;Sirolimus;Stroke;success;Toxic effect;Translational Research;transplant centers;Transplantation;Umbilical cord structure;Universities;Viral;Whole-Body Irradiation

PROJECT_TITLE: Nonmyeloablative haploidentical peripheral blood stem cell transplantation in congenital anemias


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: KELLMAN, PETER  (contact)

PROJECT_TERMS: Agreement;Artificial Intelligence;Breathing;Calibration;Cardiac;Clinical;clinical imaging;Clinical Trials;Communities;computational platform;Cooperative Research and Development Agreement;Data;data acquisition;Data Analyses;data anonymization;Data Reporting;Development;Fatty acid glycerol esters;Feedback;Foundations;Goals;heart imaging;Hospitals;Image;Image Analysis;Image Enhancement;image reconstruction;imaging system;Imaging technology;improved;Industrialization;Intelligence;invention;Life Cycle Stages;Magnetic Resonance Imaging;Maps;Methods;Modeling;National Heart, Lung, and Blood Institute;open source;Patients;Performance;Perfusion;pre-trained transformer;Reporting;Research;research and development;Resolution;Scanning;Site;software infrastructure;Speed;Training;Water

PROJECT_TITLE: Gadgetron Global Network and Intelligence Computing: Clinical Imaging Application Development and Software Infrastructure


NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Orphan Drug;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

PROJECT_TERMS: Activins;Address;Agonist;Annual Reports;ATAC-seq;Autologous;Basic Science;beta catenin;bioinformatics pipeline;Biological Assay;Blood Vessels;Bone Marrow;Bone marrow failure;bone marrow failure syndrome;Cadherins;CD34 gene;Cell Adhesion Molecules;Cell Count;Cell Differentiation process;Cell Lineage;Cell Therapy;cell type;Cells;chemokine receptor;ChIP-seq;clinical application;clinical practice;Clinical Trials;comparative;comparison control;Complex;Control Groups;CRISPR-mediated transcriptional activation;curative treatments;CXCR4 gene;Data;Data Set;Defect;design;Development;differentiation protocol;DNA;DNA Double Strand Break;dosage;Double Strand Break Repair;Ectopic Expression;effective therapy;Embryonic Development;engineered stem cells;Engraftment;Enhancers;Ensure;Epigenetic Process;experimental study;EZH2 gene;Fanconi's Anemia;flexibility;Formulation;Frequencies;Future;Gene Chips;Gene Expression;Gene Expression Profile;Gene Expression Profiling;gene repression;gene therapy;Generations;Genetic;Goals;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;hematopoietic engraftment;hematopoietic stem cell fate;Hematopoietic Stem Cell Specification;Hematopoietic stem cells;Hematopoietic System;Home;Homing;Human;human induced pluripotent stem cells;improved;In Vitro;Individual;induced pluripotent stem cell;Inflammation Mediators;Inherited;Inherited bone marrow failure;inhibitor;insight;Integrins;Investigation;Knowledge;Legal patent;Libraries;Licensing;Lymphoid;Marrow;Mediating;Mediator;Messenger RNA;Methodology;Methods;mimetics;Mitogen-Activated Protein Kinases;Molecular;Molecular Profiling;Mus;nerve stem cell;neural model;Neurons;Nodal;novel therapeutics;null mutation;Open Reading Frames;Output;overexpression;participant enrollment;Pathway interactions;Patients;peripheral blood;pharmacologic;Pharmacological Treatment;Phase I/II Clinical Trial;Phenotype;pluripotent stem cell differentiation;Polycomb;Population;Production;progenitor;programs;Protocols documentation;PTPRC gene;Publishing;receptor;Regenerative Medicine;Repressor Proteins;Research;Reserve Stem Cell;Safety;Selectins;Self Assessment;self-renewal;Signal Pathway;Signal Transduction;Specific qualifier value;stem cell population;stem cell technology;stem cells;synergism;System;Testing;therapeutic candidate;Thrombopoietin;transcription factor;Transforming Growth Factor beta;Translating;Translational Research;Transplantation;United States National Institutes of Health;vector;Work;Xenograft procedure

PROJECT_TITLE: Generation of Hematopoietic Stem and Progenitor Cells from Human iPSCs


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease

PI_NAMEs: CHEN, MARCUS  (contact)

PROJECT_TERMS: Address;American;Anatomy;Ancillary Study;Aorta;aortic valve replacement;Area;Arteries;Blood Vessels;calcification;Cardiac;Cardiology;Cardiovascular system;Clinical Research;Communities;Complex;Coronary;Coronary Angiography;Coronary artery;coronary computed tomography angiography;Coronary Stenosis;Data;detector;Diagnostic;diagnostic accuracy;Diagnostic Imaging;Dose;Enrollment;Functional disorder;Health;heart imaging;Image;Implant;improved;Intervention;Investigation;Ischemia;Laboratories;Legal patent;Life;low dose computed tomography;Low Dose Radiation;Magnetic Resonance Imaging;Medical;Methods;Multicenter Trials;Myocardial perfusion;National Heart, Lung, and Blood Institute;Needs Assessment;non-invasive imaging;patient subsets;Patients;Perfusion;Phenotype;Physiological;Procedures;programs;Protocols documentation;Radiation exposure;rare genetic disorder;recruit;Research;Research Personnel;Resolution;Risk;Safety;Severities;single photon emission computed tomography;Site;Stenosis;Stents;Stress;structural heart disease;Techniques;Technology;Testing;Uncertainty;United States National Institutes of Health;X-Ray Computed Tomography

PROJECT_TITLE: Cardiovascular CT Clinical Research


PI_NAMEs: GLANCY, BRIAN  (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Adult;Aging;Animals;Cells;Chronic;Development;Drosophila genus;Electron Microscopy;Energy Supply;Enzymes;Goals;Homeostasis;improved;in vivo;insight;interest;light microscopy;Location;Measures;Metabolic Diseases;Methods;Mitochondria;mouse model;multi-photon;multiphoton microscopy;Mus;Muscle;Muscle Cells;Muscle Contraction;Muscle Development;Muscle Fibers;Muscle Mitochondria;Obesity;Physiological;Process;programs;protein function;Regulation;Research;Reticulum;Shapes;Signal Transduction;Signaling Molecule;Skeletal Muscle;targeted treatment;Techniques;Therapeutic Intervention;Time;Transgenic Mice;ultra high resolution;Up-Regulation

PROJECT_TITLE: Development and Regulation of the Muscle Mitochondrial Reticulum


NIH_SPENDING_CATS: Cardiovascular;Infectious Diseases

PI_NAMEs: KEMPER, CLAUDIA  (contact)

PROJECT_TERMS: Ablation;Affect;Animals;Arteries;Biological;Biology;Brain;Candida;Cardiovascular Diseases;Cell Compartmentation;Cells;Collaborations;Complement;Complement Activation;Complement Factor B;complement system;Development;Disease;Event;Future;Goals;Hand;High Fat Diet;Human;in vivo;Incubated;Infection;Inflammation;inhibitor;International;Intervention;Laboratories;LoxP-flanked allele;Macrophage;Medical;methicillin resistant Staphylococcus aureus;Mitochondria;Modeling;Molecular;monocyte;mouse model;Mus;Myeloid Cells;neuroinflammation;neutrophil;novel;Pathway interactions;Patients;Permeability;Production;Regulation;Research;Residencies;Role;Signal Transduction;Sterility;T cell response;Tissues;United States National Institutes of Health

PROJECT_TITLE: The role of the intracellular complement system - the complosome - in monocytes


PROJECT_TERMS: adaptive immunity;Algorithms;Amino Acids;Anaphylatoxins;arginase;Arginine;autocrine;Autoimmune Diseases;Autoimmunity;Binding;Biology;C3 gene;C3AR1 gene;CD4 Positive T Lymphocytes;CD46 Antigen;CD8-Positive T-Lymphocytes;Cell Lineage;Cell Nucleus;Cell Physiology;Cell surface;Cells;Cellular biology;Chronic;Collaborations;comparative;Complement;Complement 3b;Complement Activation;complement C3 precursor;complement system;Contracts;cytotoxic CD8 T cells;Data;Development;disability;Disease;Economic Burden;Enzymes;Event;Extracellular Space;Fatty Acids;Gene Expression;Genes;Glutamine;Glycolysis Induction;Goals;Health;Healthcare Systems;Human;Human Activities;Hyperactivity;Immune;Immunity;Inflammasome;Inflammation;Inflammatory;Inflammatory Bowel Diseases;influenza infection;Insulin-Dependent Diabetes Mellitus;Integrins;Interleukin-10;Knowledge;Laboratories;Lipids;Macrophage;Manuscripts;Mediating;Memory;Metabolic;Metabolism;microorganism;Molecular;Natural Immunity;new therapeutic target;novel;Oxidative Phosphorylation;Oxygen;Patients;pharmacologic;Phenotype;Play;Preparation;Probability;Production;programs;Publications;receptor;recurrent infection;reduce symptoms;Regulation;Reporting;Resolution;response;Rheumatoid Arthritis;Role;Scleroderma;Signal Transduction;single-cell RNA sequencing;Sorting;T cell response;T-Cell Activation;T-Lymphocyte;Th1 Cells;Time;Tissues;transcription factor;Work

PROJECT_TITLE: The role of the intracellular complement system - the complosome - in Th1 biology


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

PROJECT_TERMS: Accelerometer;adaptive intervention;Address;Adoption;Adult;Affect;African American;African American population;African American Women;Area;Automation;Awareness;behavior measurement;Behavior Therapy;Blood Pressure;built environment;burden of illness;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Charge;chemokine;Chronic;cigarette smoking;Clinical;clinically significant;cohort;Cohort Studies;Communities;community based participatory approach;community based participatory research;community based research;community collaboration;community engagement;community intervention;community partners;community violence;Computer software;cooking;Cost Savings;cytokine;Data;depressive symptoms;Development;Dietary intake;digital applications;digital health;Education;Educational Materials;Enrollment;Environment;epidemiologic data;Ethnic Population;Event;Exercise;exercise intervention;experience;Fasting;fitbit;Focus Groups;Future;Glucose;Gold;Group Interviews;Health;health assessment;Health Care Costs;health disparity;Health Promotion;Health Technology;Heart Rate;High Risk Woman;Hour;improved;Individual;Inflammatory;Informatics;insight;Intervention;intervention effect;Jackson Heart Study;Knowledge;lifestyle factors;Link;Lipids;Location;Measures;Mediating;Mediator;member;Methods;metropolitan;mHealth;mhealth interventions;Minority Groups;Mississippi;mobile application;mobile computing;Mobile Health Application;Modeling;models and simulation;Motivation;Needs Assessment;Neighborhoods;Notification;novel;nutrition;Obesity;Obesity Epidemic;Overweight;Participant;Pathway interactions;patient engagement;Patient Self-Report;Perception;Phenotype;Physical activity;Physical environment;physical inactivity;Pilot Projects;pilot test;Population;Populations at Risk;Prevalence;Process;prospective;psychologic;psychosocial;racial population;Recreation;Reduce health disparities;Reporting;Research;Resource-limited setting;Resources;Risk;Safety;sedentary;sedentary lifestyle;Sequential Multiple Assignment Randomized Trial;Serology;Sleep;social cohesion;Social Environment;social health determinants;Social isolation;socioeconomic disparity;Standardization;stem;Stress;Structure;Surveys;Technology;technology intervention;telecoaching;Testing;therapy design;Time;tool;trend;Washington;wearable device;Weight;Well in self;Woman;Youth

PROJECT_TITLE: Tailoring Mobile Health Technology to Reduce Obesity and ImproveCardiovascular Health in Resource-Limited Neighborhood Environments: A Multi-Level, Community-Based Physical Activity Intervention


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: KOZEL, BETH  (contact)

PROJECT_TERMS: Affect;Age;Aging;Alleles;Alternative Splicing;Aneurysm;Animal Model;Aorta;Aortic Valve Stenosis;Area;Biological Process;Blood Vessels;Cell Cycle Regulation;Cell Line;Cell-Cell Adhesion;Cells;Chemicals;Chromosome 7;Chronic Obstructive Pulmonary Disease;Connective Tissue;CRISPR/Cas technology;Data;Data Set;Defect;Deposition;Development;differential expression;Disease;Disease Outcome;Distal;Elastic Cartilage;Elastic Fiber;Elastic Tissue;Elasticity;Elastin;Endoplasmic Reticulum;Enhancers;Exons;experience;experimental study;Extracellular Matrix;falls;Family;FBLN5 gene;Fiber;Gene Expression;gene product;Genes;Genetic Transcription;genome sequencing;Genomics;Human;Immunofluorescence Immunologic;improved;Individual;induced pluripotent stem cell;interest;Introns;Knowledge;Length;Literature;LOX gene;Lung;Manuscripts;Mediating;Messenger RNA;Minority;Molecular;Molecular Chaperones;Morbidity - disease rate;mortality;mouse genome;Mus;Mutation;novel;novel therapeutics;old mice;patient derived induced pluripotent stem cells;Patients;Play;Process;Production;Protein Analysis;Protein Secretion;protein transport;Proteins;Rare Diseases;Regulation;RNA Splicing;Role;Serum-Free Culture Media;Skin;Smooth Muscle Myocytes;Techniques;Testing;Time;Tissues;Transcript;transcriptome sequencing;transcriptomics;Variant;Vascular Diseases;Vascular Smooth Muscle;Vesicle;Western Blotting;Work

PROJECT_TITLE: Connective Tissue Mediated Vascular Disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: Academic Medical Centers;Accelerometer;Address;Adult;Affect;African American;African American Women;Age;Amygdaloid structure;Antibodies;atherogenesis;Attenuated;Behavior;Behavior Therapy;Biological;Biological Markers;Biology;Black Populations;Blood Banks;Blood donor;Blood Platelets;Blood specimen;Blood Vessels;Blood Volume;Brain;brain behavior;cardiovascular health;cardiovascular risk factor;Cardiovascular system;caucasian American;Caucasians;Cells;Cellular Phone;Censuses;Characteristics;chemokine;Chicago;Chronic;Chronic stress;clinically relevant;cohort;Cohort Studies;Collaborations;Communities;community violence;Complete Blood Count;COVID-19 pandemic;Crime;cytokine;Data;depressive symptoms;deprivation;Development;Dietary intake;Discrimination;District of Columbia;Ecological momentary assessment;economic indicator;Environment;Environmental Exposure;Environmental Risk Factor;epidemiologic data;Epidemiologic Methods;ethnic difference;Ethnic Population;Female;Flow Cytometry;Functional Magnetic Resonance Imaging;Global Positioning System;granulocyte;Health behavior;health disparity;Hydrocortisone;Immune;immune activation;immune function;immune system function;Immunologic Markers;improved;indexing;Individual;Inflammatory;innovation;Interdisciplinary Study;interest;Intervention;Jackson Heart Study;Knowledge;Lead;Length;leukocyte transformation;Leukocytes;Link;lipidomics;Lipids;Lymphocyte;Lymphocyte Count;Measures;Mediating;Mediator;men;Mental Depression;Methods;Mexican Americans;Minority Groups;Modeling;monocyte;Moods;multilevel analysis;Myocardial Infarction;National Health and Nutrition Examination Survey;Natural Killer Cells;neighborhood disadvantage;Neighborhoods;neural;Neurotransmitters;Not Hispanic or Latino;novel;Outcome;Pathway interactions;perceived stress;Perception;PET/CT scan;Phenotype;Physical activity;Physiological;Pilot Projects;Platelet aggregation;Policies;Population;Poverty;Protocols documentation;psychosocial;Psychosocial Factor;Psychosocial Stress;psychosocial stressors;racial difference;racial population;Reporting;Research;response;Rest;Risk;Risk Marker;Sampling;sedentary;sedentary activity;sedentary lifestyle;Severities;Sleep;social cohesion;social deficits;Social Environment;social stress;socioeconomic disadvantage;Socioeconomic Status;socioeconomics;Stains;Stress;stress symptom;stressor;structural determinants;Surveys;Technology;telomere;Telomere Shortening;Testing;Time;tool;Translational Research;Underserved Population;United States;Universities;uptake;vascular inflammation;ward;Washington;Whole Blood;Woman;Work

PROJECT_TITLE: Pilot Study for Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in Women


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Hematology;Rare Diseases;Sickle Cell Disease

PI_NAMEs: SHET, ARUN  (contact)

PROJECT_TERMS: Acute;African ancestry;Biological Assay;Biological Markers;Blood Vessels;Cells;Coagulation Process;cohort;Cohort Studies;Collaborations;Complex;Data Analyses;Deposition;Development;Endothelial Cells;Enrollment;Ethnic Origin;extracellular vesicles;Extramural Activities;factor IXa-factor VIIIa;Factor X;Factor Xa;Fibrin;follow-up;Generations;Individual;Inflammatory;Laboratories;Laboratory Research;material transfer agreement;Medicine;monocyte;National Heart, Lung, and Blood Institute;Notification;Participant;Pathway interactions;Patients;Plasma;Principal Investigator;prospective;Protocols documentation;Recording of previous events;recruit;Recruitment Activity;Recurrence;Reporting;Research Personnel;Research Subjects;Role;Sampling;Sickle Cell Anemia;sickle cell crisis;Sickle Cell Trait;sickling;System;Telephone;Testing;Thrombelastography;Thrombin;Thrombophilia;Thromboplastin;Thrombosis;thrombotic;United States National Institutes of Health;Venous;venous thromboembolism;Venous Thrombosis;Vesicle;vesicular release;Visit

PROJECT_TITLE: Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell Trait


NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Dietary Supplements;Hematology;Natural Products;Nutrition;Rare Diseases;Sickle Cell Disease

PROJECT_TERMS: Adherence;Adsorption;Anticoagulation;Antigens;atherothrombosis;Attenuated;Biological Markers;Blood;Blood coagulation;Blood Coagulation Disorders;Blood Platelets;Blood Vessels;Cell surface;Clinical;Clinical Trials Design;Coagulants;Coagulation Process;Deposition;Development;dietary;Disease;Dose;Endothelial Cells;Endothelium;Erythrocytes;Exposure to;extracellular vesicles;Factor Va;Fibrin;Fibrinolytic Agents;Flavonoids;Future;Gene Expression;Generations;Hemin;Hemorrhage;Homeostasis;Human;Hypoxia;improved;In Vitro;Inflammation;Inflammatory Response;inhibitor;Injury;Intake;Isomerase;isoquercetin;Leukocytes;Malignant Neoplasms;Measures;Mediating;Membrane Proteins;Molecular;monocyte;mortality;Mus;NF-kappa B;novel;novel strategies;Oral;Oxidoreductase;P-Selectin;Pathway interactions;Patients;Pattern;Peptide Initiation Factors;pharmacologic;phase II trial;Placebos;Plasma;Plasma Proteins;Platelet Activation;Platelet aggregation;pre-clinical;predictive marker;primary endpoint;primary outcome;Production;Protein Disulfide Isomerase;Quercetin;Recurrence;Risk;Safety;safety assessment;secondary outcome;Sickle Cell;Sickle Cell Anemia;sickling;side effect;Sulfhydryl Compounds;Surface;Switzerland;Thrombin;thromboinflammation;Thrombophilia;Thromboplastin;Thrombosis;thrombotic;Time;translational study;vascular injury;vaso-occlusive crisis;Venous;venous thromboembolism;Venous Thrombosis

PROJECT_TITLE: A Study to Evaluate the Effects of fixed dose Flavonoid Isoquercetin on thrombo-inflammatory biomarkers in subjects with stable Sickle Cell Disease


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Lung;Rare Diseases

PI_NAMEs: TORABI-PARIZI, PARIZAD  (contact)

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Affect;Alveolar Cell;Animal Model;Animals;Annual Reports;Architecture;Bacterial Pneumonia;Binding;Biology;biomarker discovery;bronchial epithelium;Bronchoalveolar Lavage;Caring;Cells;Data;Endothelial Cells;Endotoxins;Epithelial Cells;experimental study;Family;frontier;gain of function;Gene Expression;healthy volunteer;Human;Immune;Immunology;immunoregulation;In Situ;In Situ Hybridization;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Intravenous;Investigation;knockout animal;Lavage;loss of function;Lung;Lung Lavage Fluid;Membrane;migration;Natural Immunity;neuron development;neutrophil;Neutrophil Infiltration;Organ;Patients;Phenotype;Plasma;plexin;protein biomarkers;Protein Secretion;Proteins;Publications;Publishing;Pulmonary Inflammation;receptor;Reporting;Role;Semaphorins;Serum;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Source

PROJECT_TITLE: Investigations of the role of Semaphorin 5A in innate immunity


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Biotechnology;Cancer;Coronaviruses;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Lung;Orphan Drug;Pneumonia;Pneumonia and Influenza;Rare Diseases

PROJECT_TERMS: A/J Mouse;Acute;Acute Lung Injury;adaptive immune response;Address;Adverse effects;Adverse event;Affect;Animals;Antibodies;Antineoplastic Agents;Apoptotic;Body System;Cancer Patient;Cell Physiology;Cells;Cessation of life;checkpoint therapy;China;Clinical;comorbidity;Coronavirus;Country;COVID-19;CTLA4 gene;Cytotoxic T-Lymphocytes;Death Rate;Detection;Development;Disease;Dose;European;experience;experimental study;Fatality rate;Flow Cytometry;Frequencies;Goals;Health;Histology;Hospitalization;Human;human coronavirus;Human Pathology;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immune system;immune-related adverse events;Immunity;Immunosuppression;Inbred Strains Mice;Infection;infection risk;Inflammation;Inflammatory;Injury;Innate Immune Response;Ligands;Liver;Lung;lung injury;Malignant Neoplasms;Manuscripts;Modeling;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse development;mouse model;Mouse Strains;Murine hepatitis virus;Mus;Nerve Tissue;Nucleocapsid Proteins;Patients;Persons;Phenotype;Pneumonia;pneumonia model;preclinical study;programmed cell death ligand 1;programmed cell death protein 1;Proteins;Protocols documentation;Pulmonary Inflammation;Regimen;Registries;Respiratory Tract Infections;response;Rhea;Risk;Role;SARS coronavirus;SARS-CoV-2 infection;seasonal influenza;severe COVID-19;side effect;Structure of parenchyma of lung;Treatment Protocols;tumor;United States;Viral Proteins;Virus;Work

PROJECT_TITLE: The Effects of Prior Checkpoint Inhibitor (CPI) Therapy on Mouse Hepatitis Coronavirus Induced Pneumonia


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PROJECT_TERMS: 2019-nCoV;Air;animal mortality;Animals;Blood;Blood gas;Bronchoalveolar Lavage;Cells;Cessation of life;Clinical;Clinical Trials;Coronavirus;COVID-19 patient;COVID-19 pneumonia;COVID-19 treatment;Data Collection;design;Development;Evaluation;experimental study;Exposure to;Flow Cytometry;Histology;Hospitals;Hypoxemia;Hypoxia;Hypoxia Inducible Factor;Inflammatory;Inflammatory Response;Intensive Care;Liver;Lung;lung injury;Lymphopenia;Measurement;Measures;Medical;Medicine;Metabolism;Modeling;mortality;mouse model;Murine hepatitis virus;Mus;Outcome;Oxygen;Oxygen Therapy Care;oxygen toxicity;Pathogenicity;Pathway interactions;Patients;Phase;Pneumonia;pneumonia model;preclinical study;prevent;Proteins;Publishing;Randomized;Reactive Oxygen Species;Respiratory Failure;Review Literature;Rhea;SARS-CoV-2 infection;Side;Spleen;supplemental oxygen;systematic review;Testing;Therapeutic;Therapeutic Uses;Thrombocytopenia;thrombotic;Time;Tissue Banks;tissue injury;Tissues;Toxic effect;Viral;Virus

PROJECT_TITLE: The Effects of Oxygen Therapy on Mouse Hepatitis Coronavirus Induced Pneumonia


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Human Genome;Hypertension;Microbiome;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Affect;African;African American;African American population;Algorithms;American;Architecture;behavior influence;Behavioral;biobank;Biological Assay;Biological Markers;biological systems;Biosocial;Blood;Blood Pressure;Blood Vessels;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;catalyst;cloud based;Cloud Computing;cluster computing;cohort;Communities;Complex;Computer Analysis;computer infrastructure;Controlled Clinical Trials;coronary artery calcium;Data;data infrastructure;Data Set;Data Sources;depressive symptoms;Dietary Sodium;dimension reduction;Disease;disorder risk;DNA methylation profiling;Double-Blind Method;Elasticity;Enrollment;Environmental Risk Factor;Epigenetic Process;epigenome;Etiology;exome;Exposure to;Family health status;Gene Expression;Genes;Genetic;Genetic study;Genome;genome resource;genome sequencing;genomic data;Genomics;Genotype;Goals;Health;health disparity;Human;Hypertension;Image;Individual;insight;Intake;interest;Intervention;Intervention Trial;Investigation;Link;Measures;Mediator;metabolic abnormality assessment;metabolome;microbiome;MicroRNAs;Minority Health Research;miRNA expression profiling;Modeling;Molecular;mRNA sequencing;multi-ethnic;novel;Obesity;Outcome Measure;overtreatment;Participant;Pathway interactions;phenome;Phenotype;Placebos;polygenic risk score;Population;Predisposing Factor;Predisposition;programs;Proteome;Race;Renal function;Research;Research Design;Resources;response;Science;Series;Signal Pathway;social;social determinants;social disparities;social influence;Sodium;Standardization;statistical and machine learning;Structure;System;Techniques;Technology;telomere;trait;transcriptome;Urine;Variant;Vision;Whole Blood;whole genome

PROJECT_TITLE: Genetics and Epigenetics of Cardiovascular Disease


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: YOULE, RICHARD JAMES (contact)

PROJECT_TERMS: Affinity;Alzheimer's disease related dementia;Autophagocytosis;Autophagosome;Binding;Binding Sites;California;Collaborations;design;Drug Targeting;drug use screening;Engineering;Goals;National Center for Advancing Translational Sciences;National Heart, Lung, and Blood Institute;Neuroanatomy;Organelles;pharmacologic;preclinical development;protein aggregation;Proteins;Risk;Series;small molecule;tau aggregation;tau Proteins;Technology;Therapeutic;tool;United States National Institutes of Health;Work

PROJECT_TITLE: Targeting Protein Aggregates for Autophagosomal Degradation


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Stroke;Traumatic Head and Spine Injury

ORG_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

PI_NAMEs: COHEN, LEONARDO GREGORIO (contact)

PROJECT_TERMS: Activities of Daily Living;acute stroke;Adult;Age;age effect;age group;Architecture;Basic Science;Behavior;Behavioral;Brain;brain computer interface;Brain Diseases;Brain Injuries;Caring;Central Nervous System;Chronic;Clinical;Cognition;cohort;design;Development;Disease;E-learning;economic implication;effective intervention;Elderly;Eligibility Determination;Event;evidence base;Family;finger movement;forgetting;Goals;Hand;Health;healthy volunteer;Home;Hour;Human;human subject;Hybrids;Impairment;improved;Individual;Intervention;Journals;Knowledge;Learning;Learning Skill;Left;Lesion;Location;Machine Learning;Magnetoencephalography;Manuscripts;meetings;Memory;memory consolidation;memory encoding;Memory Loss;millisecond;Mission;Motor;motor deficit;motor function recovery;motor impairment;motor learning;motor rehabilitation;Motor Skills;Muscle;neural;neurological rehabilitation;Neurologist;Neurology;Neurosciences;novel;older adult;Older Population;Participant;Patients;Pattern;Peer Review;Performance;physical therapist;Physiology;Positioning Attribute;preservation;Process;programs;psychologic;Psychologist;Recovery of Function;Rehabilitation therapy;Research;Resolution;Rest;Role;Science;sensory feedback;skill acquisition;skills;skills training;Sleep;social implication;Societies;Source;Spinal cord injury;Stroke;Testing;Time;Training;Translating;Traumatic Brain Injury;Wakefulness;Work

PROJECT_TITLE: Cortical reorganization and plasticity In the healthy brain


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Cerebrovascular;Clinical Research;Coronaviruses;Disability Research;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Physical Rehabilitation;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Rehabilitation;Stroke

PROJECT_TERMS: acute COVID-19;Adult;Age;Animal Model;Brain;brain dysfunction;brain fog;Cephalic;Clinical;clinical effect;Clinical Research;clinically relevant;cognitive function;cohort;Collaborations;Compensation;Consensus;Control Groups;cost;COVID-19 pandemic;COVID-19 patient;Data;design;disability;Disease;Electric Stimulation;Executive Dysfunction;experimental study;Functional disorder;Gender;Goals;Human;improved;Injury;International;Intervention;Intramural Research Program;Journals;Knowledge;Knowledge acquisition;Laboratories;Learning;Learning Skill;Lesion;Link;Long COVID;loss of function;Magnetism;Measures;Memory;memory consolidation;Memory impairment;Metadata;Motor;Motor disability;Motor Skills;Music;National Institute of Neurological Disorders and Stroke;neural repair;neurological rehabilitation;Neurology;neuromechanism;neurophysiology;noninvasive brain stimulation;novel;novel strategies;novel therapeutic intervention;Outcome Measure;pandemic response;Paper;Patients;Performance;persistent symptom;pharmacologic;pre-clinical;pre-clinical research;pre-pandemic;primary outcome;procedural memory;Process;Protocols documentation;Publications;Publishing;Recommendation;Recovery of Function;Rehabilitation Outcome;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;Research Methodology;Research Personnel;Researching COVID to Enhance Recovery;response;SARS-CoV-2 infection;secondary outcome;sex;skills;social;somatosensory;Standardization;Stroke;stroke rehabilitation;Symptoms;Task Performances;Techniques;Therapeutic Effect;Translating;Translations;Traumatic Brain Injury;United States National Institutes of Health;Work

PROJECT_TITLE: Modulating brain plasticity in rehabilitation of stroke and other brain lesions


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Congenital Muscular Dystrophy;Congenital Structural Anomalies;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Muscular Dystrophy;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Peripheral Neuropathy;Rare Diseases

PI_NAMEs: BÖNNEMANN, CARSTEN  (contact)

PROJECT_TERMS: Address;Adolescent;Affect;Afferent Neurons;Animal Model;Antisense Oligonucleotide Therapy;Atrophic;base editing;Biological Markers;Biopsy;Breathing;Case Study;causal variant;Cell model;Centronuclear myopathy;Child;Childhood;Clinic;Clinical;Clinical assessments;clinical outcome measures;clinical translation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Cohort Studies;COL6A1;COL6A2;Collaborations;Collagen Type VI;Compensation;congenital muscular dystrophy;Congenital Myasthenic Syndromes;congenital myopathy;Dedications;Development;Disease;disease model;Dominant-Negative Mutation;Dose;Drug Kinetics;early onset;Engineering;Etiology;Evaluation;exome;exosuit;Extracellular Matrix;falls;FHL1 gene;first-in-human;Gait;gene therapy;Gene therapy trial;Gene Transfer;Genes;Genetic;genome sequencing;Genomic approach;genomic data;Genomics;giant axonal neuropathy;Goals;Growth Factor;Human;humanized mouse;Image;Imaging Device;immunoregulation;improved;induced pluripotent stem cell;Infrastructure;International;Joints;Laboratories;loss of function;Magnetic Resonance Imaging;Mediating;member;Modality;Molecular;mouse model;Muscle;Mutation;Myopathy;National Center for Advancing Translational Sciences;Natural History;Natural regeneration;neurogenetics;neuromuscular;Neuromuscular Diseases;Neuromuscular Junction Diseases;next generation;next generation sequencing;novel;Outcome Measure;Outcome Study;Pain;Pathway interactions;Patients;Pharmacologic Substance;Phase;Phenotype;phenotypic data;Piezo 2 ion channel;Positioning Attribute;precision medicine;preservation;programs;Proprioception;Protocols documentation;Rare Diseases;receptor;Research;Respiratory Muscles;RNA Interference;RNA Splicing;safety assessment;Sensory;sensory prosthesis;Signal Transduction;Syndrome;Technology;Testing;Therapeutic;therapeutic gene;Tissue Model;tool;Touch sensation;Transcript;transcriptome sequencing;Translating;Translations;trial design;United States National Institutes of Health;Validation;Visualization;whole genome;Work;X-linked myotubular myopathy

PROJECT_TITLE: Molecular and Clinical Manifestations of Matrix and Aggregate Myopathies


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Lewy Body Dementia;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: SCHOLZ, SONJA  (contact)

PROJECT_TERMS: age related;atypical parkinsonism;Autopsy;clinical diagnosis;Complex;Data;Dementia with Lewy Bodies;Development;disabling disease;disease model;Evaluation;Functional disorder;functional genomics;Genes;Genetic;genetic architecture;Genetic study;genetic variant;genome analysis;genomic data;genomic tools;Genomics;improved;International;Knowledge;Learning;Lewy Body Dementia;Mission;Modernization;Molecular;Multiple System Atrophy;Nerve Degeneration;Neurodegenerative Disorders;Neurologic;Oligodendroglia;Pathogenesis;Pathway interactions;Patients;Pre-Clinical Model;Research;risk variant;Susceptibility Gene;Syndrome;targeted treatment;Therapeutic;Translating

PROJECT_TITLE: Genetic characterization of atypical parkinsonism


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: WARD, MICHAEL  (contact)

PROJECT_TERMS: Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;analog;Autopsy;Axon;Axonal Transport;Base Excision Repairs;Binding;Biological Markers;Biology;Biophysics;Biotin;Brain;Cell Differentiation process;Cell Line;Cell model;Cell Nucleus;Cell Physiology;Cells;ChIP-seq;chromatin remodeling;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;Conceptions;CRISPR interference;Cytoplasmic Granules;data repository;Data Set;demethylation;Development;disease phenotype;Distal;DNA;DNA Single Strand Break;Doxycycline;effective therapy;Enhancers;Ensure;Event;Exons;familial Alzheimer disease;forward genetics;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Funding;Future;Gene Expression;Genes;Genetic Screening;Genome;genome editing;Genome engineering;Genome Stability;genome wide association study;genome-wide;Genomics;Glutamates;human data;human induced pluripotent stem cells;Image;improved;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Inherited;International;Link;Location;Lysosomes;Manuscripts;Maps;Mediating;Methods;Modeling;Molecular;Molecular Biology;multiple omics;mutant;Mutation;National Institute of Neurological Disorders and Stroke;Nature;Nerve Degeneration;Neurodegenerative Disorders;neuronal survival;Neurons;Neurosciences;next generation sequencing;novel;Paper;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;phenotypic data;Plasma;Play;postmitotic;Process;Production;protein TDP-43;Proteins;Proteomics;Protocols documentation;Publishing;Recurrence;repaired;Reporting;Repression;Reproducibility;Research;Research Personnel;Risk;RNA;RNA Splicing;RNA Transport;RNA-Binding Proteins;Robotics;Rodent;Seminal;Single-Stranded DNA;Site;stem cells;synaptic function;System;Techniques;Technology;Thymidine;Transcript;Translations;ward

PROJECT_TITLE: Mechanisms of inherited neurodegenerative diseases


NIH_SPENDING_CATS: Aging;Biotechnology;Brain Disorders;Clinical Research;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease

PI_NAMEs: NARENDRA, DEREK  (contact)

PROJECT_TERMS: aging population;Alleles;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Antisense Oligonucleotide Therapy;Autophagocytosis;Benign;biological adaptation to stress;Brown Fat;burden of illness;Cell Line;Cell Nucleus;Cells;Clinic;clinical center;Collaborations;Complement;Crista ampullaris;Cytosol;Data Set;Disease;early onset;Engineering;Family;Frontotemporal Dementia;Gene Expression;Genetic;genome wide screen;Goals;Growth;induced pluripotent stem cell;Inner mitochondrial membrane;Intramural Research Program;Investigation;Knock-in;Knock-in Mouse;Knock-out;Liver;loss of function;Maintenance;Mammals;Measures;Mediating;Membrane;Mendelian disorder;metabolic imaging;Methods;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial Myopathies;Mitochondrial Proteins;Modeling;Molecular Diagnosis;mouse model;Mus;Muscle;mutant;Mutation;Myocardium;Myopathy;nanoscale;Nerve Degeneration;Neurodegenerative Disorders;Neurologist;Neurons;novel;OPA1 gene;paralogous gene;Parkin;Parkinson Disease;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peptide Hydrolases;PINK1 gene;postmitotic;Precision therapeutics;prevent;programs;Protein Biosynthesis;protein degradation;protein misfolding;Proteins;Proteomics;Reporter;response;Signal Transduction;Skeletal Muscle;sporadic Parkinson's Disease;Stress;therapy development;Tissues;United States National Institutes of Health;Variant

PROJECT_TITLE: Mitochondrial stress responses in neurodegeneration


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

PI_NAMEs: GRUNSEICH, CHRISTOPHER  (contact)

PROJECT_TERMS: Accelerometer;Adaptor Protein Complex 2;Affect;Alleles;amphiphysin;Amyotrophic Lateral Sclerosis;analog;Androgen Receptor;Auxilins;Binding;Biological Markers;Biology;biomarker identification;Cell Line;Cells;Cerebrospinal Fluid;Clinical;Clinical Markers;Clinical Research;Clinical Trials;Collaborations;CRISPR interference;Curcumin;Development;Disease;Disease Progression;efficacy evaluation;Endocytosis;EPS15 gene;epsin;exome sequencing;Family member;Future;Genes;Genetic Screening;genetic testing;Goals;Health;Hereditary Spastic Paraplegia;Image;improved;indexing;induced pluripotent stem cell;Infrastructure;Inherited;instrument;Intellectual functioning disability;Limb structure;Liquid substance;Magnetic Resonance Imaging;Measurement;Measures;Missense Mutation;Modality;Molecular;molecular marker;Motor Cortex;motor neuron degeneration;Motor Neuron Disease;Motor Neurons;Muscle;Muscle function;mutant;Mutation;Natural History;Nerve;Nerve Degeneration;neuromuscular;Neuromuscular Diseases;Neurons;novel;novel strategies;oligonucleotide therapeutics;Outcome Measure;Pathway interactions;Patient Outcomes Assessments;Patients;Pharmacodynamics;Physical Function;Process;Proteins;Reproducibility;Research;Safety;Sampling;Seizures;Serum;Severities;Small Interfering RNA;specific biomarkers;Spectrum Analysis;spinal and bulbar muscular atrophy;Testing;TFRC gene;Therapeutic;therapeutic candidate;Therapeutic Studies;therapy development;Tissue Sample;Tissues;tool;Toxic effect;ultrasound;Universities;Validation;Work

PROJECT_TITLE: Studies of inherited neuromuscular diseases


ACTIVITY: ZIH

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: BROOKS, BERNARD R (contact)

PROJECT_TERMS: Acceleration;Address;Advanced Development;Agreement;Algorithms;Architecture;Benzene;Biological Models;Chemicals;Code;Common Core;Communication;computer grid;Computer Hardware;Computer software;computerized tools;Computers;Consumption;cost;cost effective;Coupled;Data;Data Set;density;Development;Diffusion;Directories;Electrostatics;Evaluation;Fourier Transform;Free Energy;Graph;High Performance Computing;Home;Hydrogen Bonding;improved;induced pluripotent stem cell;interest;Lead;Linux;Literature;Machine Learning;Maps;Mechanics;Methods;Modeling;Modernization;Molecular;Molecular Analysis;Molecular Conformation;molecular dynamics;molecular mechanics;Network-based;neural network;novel strategies;open source;Operating System;parallel computer;parallelization;particle;Peptides;Performance;Personal Computers;Probability;protein folding;Pythons;Quantum Mechanics;Radial;Random Allocation;Resources;Running;Sampling;Scheme;scientific computing;simulation;software development;solute;Solvents;Speed;Structure;System;Techniques;Technology;Testing;Time;Training;two-dimensional;United States National Aeronautics and Space Administration;Update;Uracil;Water;Work;Writing

PROJECT_TITLE: Development Of Advanced Computer Hardware And Software


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: FREDERICK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

ORG_STATE: MD

PI_NAMEs: DMITROVSKY, ETHAN  (contact)

PROJECT_TERMS: Agreement;Aliquot;Brain;Brain Neoplasms;Cancer Model;chemoradiation;Childhood;Clinical;Clinical Data;Communities;Contracts;Data;Data Element;data sharing;Diffuse intrinsic pontine glioma;DNA;DNA sequencing;Enrollment;follow-up;Funding;Generations;Genomic Data Commons;human subject;Infrastructure;Institutional Review Boards;Laboratories;Malignant Childhood Neoplasm;Malignant Neoplasms;Modeling;Normal tissue morphology;Operative Surgical Procedures;Parents;Patients;Policies;Process;programs;Protocols documentation;Reporting;Resources;sample collection;Sampling;Solid;Time;Tissues;transcriptome sequencing;Treatment outcome;tumor;Tumor Tissue

PROJECT_TITLE: CANCER MODELS FROM PEDIATRIC BRAIN AND SOLID CANCERS (CMDC)


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PI_NAMEs: BEASLEY, DAVID  (contact)

PROJECT_TERMS: 2019-nCoV;Animal Model;Animals;Basic Science;Contracts;Coronavirus Infections;COVID-19 test;Development;Evaluation;Human;Lung;microphysiology system;Modeling

PROJECT_TITLE: Task C14: Advancing Human Lung Microphysiological Systems to Model Coronavirus Infection and Test Candidate Countermeasures


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: ROCKVILLE

ORG_NAME: SIGMOVIR BIOSYSTEMS, INC.

PI_NAMEs: BOUKHVALOVA, MARINA  (contact)

PROJECT_TERMS: Basic Science;Collection;Contracts;Development;Evaluation;in vivo;infectious disease model;Metadata;Virus

PROJECT_TITLE: Task A07: Collection of Metadata from In Vivo Studies Performed Under Previous IDIQ Contract Mechanisms


PROJECT_TITLE: Task A06: Collection of Metadata from In Vivo Studies Performed Under Previous IDIQ Contract Mechanisms


ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PI_NAMEs: SLAYDEN, RICHARD  (contact)

PROJECT_TITLE: Task A05: Collection of Metadata from In Vivo Studies Performed Under Previous IDIQ Contract Mechanisms


ORG_CITY: LOGAN

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PI_NAMEs: GOWEN, BRIAN  (contact)

PROJECT_TITLE: Task A08: Collection of Metadata from In Vivo Studies Performed Under Previous IDIQ Contract Mechanisms


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: Animals;Basic Science;Contracts;Development;Evaluation;infectious disease model;Lassa virus;medical countermeasure;Modeling;Viral Physiology;Virus Diseases

PROJECT_TITLE: Task A02: Development of Small Animal Lassa Virus infection Model for the Assessment of Anti-Viral Activity of Medical Countermeasures Efficacy


ORG_NAME: BIOQUAL, INC.

PROJECT_TERMS: Contracts;Development;infectious disease model;medical countermeasure;Modeling;Pre-Clinical Model;Reagent

PROJECT_TITLE: Pre-Clinical Models of Infectious Diseases


ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME


ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA


ORG_CITY: MANASSAS

ORG_NAME: AMERICAN TYPE CULTURE COLLECTION

ORG_STATE: VA


ORG_CITY: COLUMBUS

ORG_NAME: BATTELLE CENTERS/PUB HLTH RES & EVALUATN

ORG_STATE: OH


ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA


ORG_CITY: SALISBURY

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: DEFENCE SCIENCE & TECHNOLOGY LABORATORY

ORG_ZIPCODE: SP4 0JQ


ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA


ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY


ORG_CITY: BIRMINGHAM

ORG_NAME: SOUTHERN RESEARCH INSTITUTE

ORG_STATE: AL


ORG_CITY: CHICAGO

ORG_NAME: IIT RESEARCH INSTITUTE

ORG_STATE: IL


ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE


ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI


ORG_CITY: CAMBRIDGE

ORG_NAME: CHARLES STARK DRAPER LABORATORY


ORG_CITY: FORT WORTH

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR


ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL


ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON


ORG_NAME: UK HEALTH SECURITY AGENCY


ORG_CITY: ROCKVILLE

ORG_NAME: SIGMOVIR BIOSYSTEMS, INC.


ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

ORG_STATE: NY


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH


ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY


ORG_NAME: UNIVERSITY OF CHICAGO


ORG_CITY: GAITHERSBURG

ORG_NAME: MIMETAS US, INC.


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY


ORG_CITY: MANASSAS

ORG_NAME: AMERICAN TYPE CULTURE COLLECTION


ORG_CITY: SASKATOON

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF SASKATCHEWAN

ORG_STATE: SK

ORG_ZIPCODE: S7N 5C9


ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC


ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO


ORG_NAME: BIOQUAL, INC.

ORG_STATE: MD


ORG_CITY: SALISBURY

ORG_NAME: DEFENCE SCIENCE & TECHNOLOGY LABORATORY


ORG_CITY: NEW TAIPEI CITY

ORG_COUNTRY: TAIWAN

ORG_FIPS: TW

ORG_NAME: PHARMACOLOGY DISCOVERY SERVICES TAIWAN, LTD.


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA


ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN


ORG_CITY: CHICAGO

ORG_NAME: IIT RESEARCH INSTITUTE


ORG_CITY: Schenectady

ORG_NAME: INSTITUTE FOR CLINICAL PHARMACODYNAMICS


ORG_CITY: LOGAN

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT


ORG_CITY: MOBILE

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA


ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA


ORG_CITY: ROCKVILLE

ORG_NAME: BIOMEDICAL RESEARCH INSTITUTE


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Valley Fever

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PI_NAMEs: PATTERSON, THOMAS  (contact)

PROJECT_TERMS: Coccidioides immitis;Coccidioides posadasii;Contracts;Development;Diagnostic;Evaluation;fungus;infectious disease model;mouse model;Mycoses;Testing;therapeutic development

PROJECT_TITLE: Task A89: Candidate Testing in Murine Models of Fungal Infections


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PROJECT_TERMS: Alpha Virus;Animal Model;Arenavirus;biodefense;Contracts;Development;Evaluation;infectious disease model;therapeutic development;Vaccines;Virus

PROJECT_TITLE: Task A91: Small Animal Models for Biodefense Viruses


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PROJECT_TERMS: Contracts;Development;Ebola;Evaluation;infectious disease model;medical countermeasure;model development;nonhuman primate;therapeutic development

PROJECT_TITLE: Task B16: Model Development and Medical Countermeasures (MCMs) for BSL-4 Agents in NHPs


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

PI_NAMEs: BARIC, RALPH  (contact)

PROJECT_TERMS: Anti-viral Agents;anti-viral efficacy;Contracts;Coronavirus;Development;Evaluation;infectious disease model;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Modeling;Mus;therapeutic development;Virus

PROJECT_TITLE: Task A92: Efficacy of Antiviral Therapeutics Against MERS-CoV in a Mouse-Adapted Virus Model


NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PI_NAMEs: TZIPORI, SAUL  (contact)

PROJECT_TERMS: Contracts;Development;efficacy study;Evaluation;Infection;infectious disease model;minimal inhibitory concentration;Modeling;Oryctolagus cuniculus;Testing;therapeutic development;Treponema pallidum;Treponema pallidum subspecies pallidum

PROJECT_TITLE: Task A95: Minimal Inhibitory Concentration (MIC) Testing and Efficacy Studies in a Rabbit Model of Treponema Pallidum Infection


PI_NAMEs: TOTH, KAROLY  (contact)

PROJECT_TERMS: Adenoviruses;Contracts;Development;Evaluation;Hamsters;Human;infectious disease model;Modeling;therapeutic development

PROJECT_TITLE: Task A09: Hamster Model for Human Adenovirus


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PROJECT_TERMS: 2019-nCoV;acute infection;Biology;Blinded;Cause of Death;clinical investigation;Communicable Diseases;Coronavirus;Data;Disease;Emerging Communicable Diseases;Emerging infection;Funding;Human;improved;Incidence;Infectious Agent;innovation;Medical;Medical Research;pathogen;Pathogenesis;Patient-Focused Outcomes;previous outbreak;Protocols documentation;Publishing;Randomized;respiratory virus;Safety;Therapeutic

PROJECT_TITLE: LEIDOS FUNDING TO25, OPTION 1 MEASLES


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

PROJECT_TERMS: Area;clinical research site;Collaborations;Communicable Diseases;Contractor;cost;data management;Ebola;Emerging Communicable Diseases;Funding;Human Resources;improved;Information Technology;Infrastructure;Internet;Location;Medical;meetings;Needs Assessment;Patient-Focused Outcomes;Preparation;Protocols documentation;recruit;Research Support;Role;Services;Site;Teleconferences;Telephone;Training;web site;Work

PROJECT_TITLE: LEIDOS FUNDING TO59, OPTION 3


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Pediatric

ORG_NAME: FISHER BIOSERVICES, INC.

PI_NAMEs: MARTIN, BRITTANY  (contact)

PROJECT_TERMS: Address;Age;Authorization documentation;Bar Codes;Best Pharmaceuticals for Children Act;Blood;Cells;Child;Childhood;Clinical Data;Conduct Clinical Trials;Congresses;Contracts;Data;dose information;Drug Prescriptions;Dryness;Ensure;Equipment and supply inventories;Erythrocytes;Formulation;Funding;Future;Goals;Human Milk;improved;Instruction;Knowledge;Label;Modification;Monitor;National Institute of Child Health and Human Development;Online Systems;Orphan;Pharmaceutical Preparations;Pharmacologic Substance;Plasma;repository;Research;Safety;Sampling;Serum;Services;Specimen;Spottings;System;Testing;Therapeutic;Time;Tube;Work

PROJECT_TITLE: CONTINUED REPOSITORY SERVICES FOR THE BEST PHARMACEUTICALS FOR CHILDREN ACT (BPCA)


NIH_SPENDING_CATS: Asthma;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: Affect;Air;Air Pollutants;Air Pollution;Algorithm Design;Antigens;Asthma;asthma exacerbation;asthmatic;Autoantigens;base;Bioinformatics;Biological;Biometry;Biostatistical Methods;Budgets;Cell Proliferation;Cells;Chronic Disease;Clinical;Clinical Research;Collection;Computing Methodologies;Contractor;Contracts;Defect;dietary antioxidant;Environmental Exposure;Environmental Risk Factor;experience;Exposure to;Fetus;First Pregnancy Trimester;Funding;Genetic;Hypersensitivity;Immune;immune function;Immune response;Immune system;improved;interest;Intramural Research;Knowledge;Life;Maintenance;maternal immune system;Mediating;National Institute of Child Health and Human Development;pathogen;Patients;Play;population health;Postpartum Period;Predictive Factor;Pregnancy;pregnancy immunology;Pregnancy Outcome;Pregnant Women;preservation;Process;Prospective, cohort study;Pulmonary Inflammation;Regulatory T-Lymphocyte;repository;Research;Research Contracts;research study;Residual state;Role;Sampling;Services;Severities;Specimen;study population;Subgroup;Th2 Cells;Woman

PROJECT_TITLE: B WELL MOM ASTHMA STUDY REPOSITORY CONTINUANCE - FISHER BIOSERVICES


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: IRVINE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE  Stem cell-based regenerative therapies or in vitro investigations of cardiovascular disease pathophysiology, drug screening, and toxicology studies heavily rely on stem cell quality. Here, peptide nanostructures will be engineered to enable cells to be light responsive in a wireless and non-genetic manner, which can ultimately be utilized as a strategy for converting optical cues to stimulatory signals that can improve the structural and functional maturity of human stem cell-derived cardiomyocytes. With this new approach, we hope to alleviate the major technical barrier of CM immaturity, and therefore, better enable stem cell-based cardiovascular research and related fields to flourish.

PI_NAMEs: ARDOÑA, HERDELINE ANN MALLARI (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Action Potentials;Address;Adult;Animal Model;Anisotropy;Architecture;Automobile Driving;Behavior;Binding;biomaterial interface;Biophysics;Calcium;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiovascular Diseases;Cardiovascular system;Cell Culture Techniques;Cell Survival;Cells;Charge;Chemical Stimulation;chromophore;combinatorial;conditioning;Cues;design;disease mechanisms study;drug discovery;Drug Screening;Electric Stimulation;Electrodes;Engineering;Ensure;Epitopes;extracellular;Film;Frequencies;Functional disorder;Gene Expression;Generations;genetically modified cells;Goals;Heart Diseases;Heart Injuries;Heating;high throughput screening;human induced pluripotent stem cells;human stem cell-derived;improved;In Vitro;indexing;infection risk;innovation;instrumentation;Investigation;irradiation;Light;Measurement;Measures;Mechanics;Mediating;Metabolism;Methods;Microelectrodes;minimally invasive;Modeling;Monitor;monomer;Muscle Cells;Nanostructures;Neonatal;non-genetic;novel strategies;Optics;optogenetics;Pattern;Peptide Library;Peptides;personalized medicine;Phenotype;Polymers;Process;Protocols documentation;Rattus;Reaction;regenerative therapy;Reporting;Research;Resolution;response;Risk Assessment;Risk Reduction;scale up;Side;Signal Transduction;Source;spatiotemporal;species difference;stem;stem cell based approach;stem cells;Stimulus;Stress;Structure;success;Surface;Technology;temporal measurement;Testing;Therapeutic;Tissues;Toxicology;Transducers;Transfection;Ventricular;wireless

PROJECT_TITLE: Diversity Supplement: Optically Promoting Cardiac Maturation Using Engineered Peptides

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]